10 / 66 and DSM-IV dementia diagnosis as established by the survey questionnaires was validated by comparing against a gold standard of clinical assessment.
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11β-HSD1 activity was present ex vivo in both species and increased with age in human skin tissue explants.
11β-HSD1 regenerates active glucocorticoids from their inactive 11-keto derivatives and is widely expressed throughout the adult CNS.
129S1 / SvlmJ mice were fed for @number@ @number@ @number@ and @number@ days with either LMN or control diets.
14-3-3ζ is present in NFTs and is significantly upregulated in AD brain.
15-epi-LXA4 is an anti-inflammatory , bioactive lipid formed when aspirin acetylates cyclooxygenease-2 and redirects cyclooxygenease-2 catalytic activity away from prostaglandins.
15 ( @number@ ) ] .
17-Beta-estradiol ( E2 ) facilitates long term-potentiation ( LTP ) and increases spine synapse density in hippocampal neurons of ovariectomized rodents.
1858T / T genotype was observed more frequently in T1D and GD patients compared to control subjects.
[ 18F ] -FEPPA PET scans were acquired on @number@ healthy subjects and analyzed using a full kinetic compartment analysis.
1900-1920 ) .
1910s-1920s ) .
1910s-1920s ) .
1940s : radiotherapy improved.
1950s : chemotherapy and intubation.
1960s : magnified vision , ventriculo-peritoneal ( VP ) shunts , megavolt ( MV ) irradiation.
1970s : CT , microscope , bipolar coagulation , shunt filters , neuroanesthesia , chemotherapy trials and staging studies.
1980s : magnetic resonance imaging ( MRI ) , Cavitron ultrasonic aspiration ( CUSA ) , laser surgery , hyper-fractionated radiotherapy ( HFRT ) .
1990s : pediatric neurosurgery , proton beams , stem cell rescue.
1A ) or their pictures ( Expt.
1B ) on background scenes.
20GPPD is the primary bioactive metabolite of Rb1 , a major ginsenoside found in ginseng ( Panax ginseng ) .
20p13 ) as the cause of PD.
21st century : molecular genetics.
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23andMe genotyping determined genetic ancestry.
23-Hydroxytormentic acid ( 23-HTA ) has been demonstrated to improve drug-induced nephrotoxicity and exhibit several free radical scavenging effects with other molecules.
24-hour treatment with @number@ μmol / L H₂O₂ induced remarkable up-regulation of HO-1 and PARP-1 in ARPE-19 cells.
2- [ 4- ( ) phenoxy ] -2-methyl-propionic acid ( MHY908 ) has been shown to prevent insulin resistance-induced hyperinsulinemia in aged rats.
25-30 years of the natural in vivo glycation.
25-Hydroxyvitamin D ( 25 ( OH ) D ) insufficiency is very common in many countries.
25 ( @number@ ) , iv.
25 ( OH ) D and FT showed similar seasonal or monthly variation after adjustment for age.
25 ( OH ) D and NO x levels were determined using high-performance liquid chromatography and spectrophotometrically using Griess reaction , respectively.
25 ( OH ) D concentrations were measured in plasma samples drawn in @date@ , using an electrochemoluminescent immunoassay.
25OHD was associated with intramuscular VDR protein concentration ( R = 0.67 ; P = 0.0028 ) .
25 ( OH ) D was measured in blood samples collected at baseline and the 5-year follow-up visit.
25 ( ОН ) D levels were from @number@ to @number@ nMol / L ( mean @number@.9±22.7 ) .
27 / 502 methylation probes in @number@ different genes were associated with age.
2a ) Nursing staff , employed mealtime assistants , volunteers or relatives / visitors can help with mealtime assistance.
2b ) Social interaction at mealtimes should be encouraged.
2-nonanone was a marker in Ps. aeruginosa in sputum headspace gas with sensitivity of @percent@ and specificity of @percent@.
2-way ANOVA and the Tukey test were used to compare the data ( p > 0.05 ) .
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30-day unadjusted mortality was @number@ versus @number@ % for younger patients ( p < @number@ ) .
30 ( @number@ ) ] , and ECFCs [ Median ( IQR ) : @date@ ( @number@ ) , @date@ ( @number@ ) , iii.
31 : 1886-1899 ) .
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3-D digital surface imaging and standardized 2-D photography were used to assess mid-face and nasolabial volumetric correction and clinical improvement , respectively.
3D modeling together with volume measurements revealed that mice with ventricle surface scarring developed expanded ventricles , independent of neurodegeneration.
3D motion capture was used to analyse sagittal and coronal plane gait parameters while participants walked at a comfortable speed.
3D , particularly highlights the major impact of aging on the perioral area , which was up to now neglected compared to other facial areas.
3-D regional WMH volume is a potentially valuable marker for CVD based on associations with cortical CBF and WM CBF.
3-D scapular kinematics were obtained using an electromagnetic tracking device.
3D-SSF is able to extract WM bundles at a population level , while considering WM variation across subjects and eliminating outlier streamlines.
3-MA , a classical autophagy inhibitor , attenuated ART-induced autophagosome formation , cell growth repression , G2 / M arrest , and p21 upregulation.
3-nitrotyrosine ( 3NT ) is an oxidative posttranslational modification associated with many diseases.
3T 3D CE-MRA is as accurate and effective as DSA for the evaluation of UIAs.
40-49-year period is peculiar for manifestation of prolonged effects of endogenous and exogenous factors.
415G > A ) ; one in GJA8 ( c.
438 : 500-503. ) .
44 : 443-458 ) .
47 ( @number@ ) , iv.
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4-Hydroxy-2-nonenal ( HNE ) , a lipid peroxidation product , reacts with lipoic acid resulting in enzyme inactivation.
4-hydroxynonenal was associated with hyperlipidemia and cerebral microbleeds , but not with extensive WMH or AD.
4mm ) , increasing in the lower thoracic and upper lumbar vertebrae ( by @number@ mm for length and ca.
4-Vinylcyclohexene diepoxide ( VCD ) was administered to rats for @number@ days to induce POF.
53BP1 binds to lamins A / C via its Tudor domain , and this is abrogated by DNA damage.
57 / 178 and 26 / 492 microRNAs were altered in late passage skin and lung cells respectively.
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5-Alpha-reductase inhibitors ( 5-ARIs ) decrease the production of dihydrotestosterone within the prostate , which results in decreased prostate volume.
5-year relative survival for patients diagnosed with HL in Germany was close to @percent@ for younger patients.
5-year relative survival ranges from greater than @percent@ in patients with stage I disease to slightly greater than @percent@ in patients with stage IV disease.
5-α Reductase type @number@ ( SRD5A2 ) is a critical enzyme for prostatic development and growth.
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6-OHDA-induced IκB-α degradation , NF-κB p65 nuclear translocation , p53 and PUMA expression were partially blocked by Z-FY ( t-Bu ) -DMK.
6- vs. @number@.5-fold higher PEN level than in glucosylated samples ) .
75-90-year-old adults living independently in Central Finland were interviewed (
7-8 h ) ; , however , actual sleep duration averaged only @number@ h.
8-10% of total APP is palmitoylated in vitro and in vivo.
81 / 2008 , and EN @number@ series , which recommend limits valid also for manual material handling , and pushing and pulling.
823G > A ) , and two in LIM2 ( c.57G > A , c.67A > C ) .
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8 / ( @number@ ) , iv.
8-OHdG analysis of mtDNA damage revealed substantial protective potential of the extract against mtDNA damage.
8-oxo-2'-deoxyguanosine ( 8-oxo-dG ) is a nucleoside resulting from oxidative damage and is known to be mutagenic.
8-Oxo-dG has been related to aging and diseases , including neurological disorders and cancer.
8-OxoG is removed from the DNA via DNA base excision repair ( BER ) , initiated by 8-oxoguanine DNA glycosylase-1 ( OGG1 ) .
94·4% and 13·2% smoked tobacco ( P < 0·0001 ) .
95%CI @number@ @date@ ; P = @number@ ) .
99mTc-HMPAO SPECT images were visually and semiquantitatively analyzed on days @number@ and @number@ after SAH.
99th percentiles were calculated based on age , sex , race and body mass index categories.
A 10-year increase in age leads to a @number@ times more chance to have the MetS.
A 120-item food frequency questionnaire was used to ascertain daily intake of folate , vitamin B12 , vitamin B6 , zinc , and methionine.
A 12-month baseline period before the first HbA1c value ( index date ) was evaluated for demographic and clinical differences.
A 12-point Cattermole ( CS ) score and 10-point insonation ( IS ) score were used to evaluate scan quality and ease of insonation.
A 13-variable model with strong predictive performance was generated using a forward search strategy ( mean AUC = @number@ ) .
A 19-year-old woman developed high fever , headache , and nausea after taking Loxoprofen for pharyngitis , followed by disturbed consciousness and nuchal stiffness.
A 1-unit increase in DS score was associated with a @percent@ increase in total care cost.
A 204-patient TMA was stained for TXS , VEGF , and CD-31 expression.
A 24-hour pharmacokinetic profile for testosterone and estradiol was obtained at the end of week @number@
A 24-week , double-blind , randomized , placebo-controlled trial was performed.
A2A is the adenosine receptor present in platelets ; it is known that inosine is not an A2A ligand.
A 2-hour decrease in hours per day on duty approached significance.
A2M gene and protein expression in the brain were significantly associated with gene and protein expression levels of calcineurin.
A2M increases the expression of CD29 and CD44 but did not evoke EMT.
A 2-stage design was employed.
A 2-way interaction between depressive symptoms and negative emotionality was significant for the peak to bed slope and for waking levels of cortisol.
A 2-year extension of the 3-year treatment study demonstrated the sustained efficacy of BZA over @number@ years of treatment.
A 2-year follow-up was performed in these patients who harbored mutation.
A 2-year retrospective chart review was performed of all admitted acute burn patients @number@ years or older.
A 3D motion capture system was used to parse finger movements into planning and motor execution times.
A 3-mm punch biopsy was taken from each side of the face before randomization and start of therapy.
A 3-stage study was conducted to evaluate the genetic association between BDNF and AD.
A 40-item frailty index was constructed.
A 41-year-old woman presented to our clinic for focal erythematous plaque on hyaluronidase injection site.
A 42-year-old male patient with intermittent diarrhea accompanied by bloody mucopurulent stools was admitted to our hospital.
A 44-year-old woman diagnosed with Werner syndrome developed bilateral retinal detachment.
A 45-year-old man was hospitalized because of weight loss , finger tremor , thirst , polydipsia and increased urinary frequency.
A 45-year-old patient had HIV infection detected after the appearance of motor abnormalities , in the absence of other signs or symptoms.
A 49-year-old Korean male patient with dementia was diagnosed with probable early-onset Alzheimer's disease ( AD ) .
A 4-digit display was followed by a cue indicating which @number@ of @number@ digits were relevant.
A 4-h boil treatment ( n = @number@ ) was performed post-experiment for completion of data.
A 4-item positive affect scale and an 11-point visual analog pain scale were collected at discharge and at @number@ months postdischarge.
A 4-point Likert scale ranging from \ "very strong \ " to \ "very weak \ " estimated sense of belonging to the local community.
A50 : P50 MTH ratio was calculated to evaluate site-specific thigh muscle loss. aLM and percent body fat were also determined using a DXA.
A50 : P50 MTH ratio was inversely ( p < @number@ ) correlated to zigzag walking time in both men and women.
A 50-year-old HIV-infected subject with chronic pulmonary disease had the equivalent level of function as a @number@.1-year-old uninfected subject with chronic pulmonary disease.
A53T mice also exhibit spatial memory deficits at @number@ and @number@ months , as demonstrated by Y-maze performance.
A549 or HeLa cells were treated with the mitochondrial complex II inhibitor , 3-nitropropionic acid ( 3NP ) , or an anticancer drug , doxorubicin.
A 55-year-old patient presented for erectile dysfunction , loss of libido and fatigue.
A 56-year-old white man with multiple , discrete nonfollicular papules on the neck is presented.
A 56-year-old woman presented with red-purple blotches on both forearms which had suddenly appeared without any pain , pruritus or trauma.
A 5-item score was then derived and the area under the ROC curve was @number@ ( @percent@ IC : 0.728-0.851 ) .
A 5-year age increase contributed to the prevalence change across waves.
A 5-year higher Δage is associated with a @percent@ higher mortality risk , adjusting for age and sex.
A 5-year longitudinal analysis in @number@ subjects indicated a greater decline in eGFR in parallel with the increase in baseline UBCR.
A 5-year period of oral service was simulated by thermal cycling and mechanical loading ( TCML ) .
A 60-day intervention study was conducted in which the participants took a low dose of a multivitamin and mineral supplement.
A 61-year-old woman presented with a 16-year history of a slow-growing mass underneath the right chest wall.
A 62-year-old male patient presented with heart failure after experiencing a long period of unexplained and untreated gastrointestinal symptoms.
A 65-year-old man presented with complaints of general malaise and severe disturbance of consciousness since @number@ months prior to admission.
A 69-year-old woman was diagnosed with a germ cell tumor in the anterior mediastinum.
A 70-year-old man presented to the clinic complaining of a productive cough.
A 72-item instrument was administered to @number@ community-dwelling older adults.
A 72-year-old woman developed new-onset depression , sustained an unexplained fall , and started walking cautiously.
A 72-year-old woman with slowly progressive type @number@ diabetes ( SPIDDM ) was admitted to our hospital because of increasing abdominal pain and diarrhea.
A 73-year-old male underwent coronary artery bypass grafting in @date@ , and was negative for HBsAg but positive for anti-HBs.
A 73-year-old woman developed rapidly progressive gait disturbance and cognitive dysfunction.
A 74-year-old man who was referred to our late onset hypogonadism clinic presented with sweating and loss of appetite.
A 75-year-old female patient had been diagnosed with type @number@ diabetes mellitus for @number@ years and she has been treated by liraglutide for @number@ months.
A 78-year old woman who presented with akinetic mutism was admitted to our hospital.
A 7-d dietary record was completed at age @number@ y ( n = @number@ ) .
A 7-point scale ( 0-7 ) was derived from responses to the Confusion Assessment Method for the ICU and Richmond Agitation-Sedation Scale items.
A 7-year follow-up study also revealed that a worsening in the frailty status was associated to a significant decrease in the global DNA methylation levels.
A 9-item Patient Health Questionnaire assessed current symptomatology.
AAA is commonly asymptomatic , and in the absence of routine screening , diagnosis is usually incidental when imaging to assess unrelated medical complaints.
AA amyloid fibrils are abnormal β-sheet-rich forms of the serum precursor SAA , with conformational changes that promote fibril formation.
AAC was evaluated by radiography and dual-energy x-ray absorptiometry ( DXA ) at follow-up.
AA diameter is greater in men and strongly influenced by aging and overweight.
AAL technologies aim at supporting independent living at home and therefore , include a wide variety of innovations.
A análise multivariada foi baseada nas regressões logísticas binomial e multinomial.
AA participants with low SES exhibited significantly greater WM lesion volumes than white participants with low SES.
Aaptamine also decreased proinflammatory cytokines such as cyclooxygenase-2 , tumor necrosis factor-α , interleukin-1β , and nuclear factor-kappa B subunits in UVB-irradiated human keratinocytes.
Aaptamine , a marine alkaloid isolated from the marine sponge , has been reported to have antitumor , antimicrobial , antiviral , and antioxidant activities.
AAR was found to increase with age.
AASDD was defined based on normative data in young and middle-aged subjects.
AASI was defined as @number@ minus the regression slope of the diastolic blood pressure measurement over the systolic blood pressure measurement for each patient.
AAs without cognitive impairment had a lower average baseline of cognition than EAs , but the slopes of cognitive decline were similar.
AAT deficiency is a genetic disease that manifests with emphysema and liver cirrhosis due to the accumulation of a misfolded AAT mutant in hepatocytes.
AA was infused for the remainder of the study.
AA was larger in patients with coronary artery disease ( CAD ) ( p < @number@ ) .
AA was visualized by subcostal view in longitudinal and transverse plans in order to determine the greatest anterior-posterior diameter.
A background of degenerative disease and occult presentation in the elderly may delay diagnosis.
A bad adjustment of the model is detected and a scobit link is added , which helps to differentiate disabled and non-disabled individuals better.
A balanced time perspective predicted higher scores on both measures of well-being replicating the original J.D. Webster ( @number@ ) findings.
A balance of control exerted by these systems is thought to be related to dopamine neurotransmission.
A baseline assessment and follow-up over @number@ months was scheduled for each patient.
A baseline dietary questionnaire was extrapolated into a previously used 9-point scoring system ( MeDi ) .
A baseline HBsAg level of @number@ IU / mL was the optimal cut-off value for predicting post-treatment HBV relapse ( P = @number@ ) .
A baseline questionnaire was used to ascertain demographic characteristics and prior type and amount of contact with older adults.
A battery of cognitive tests that assessed episodic memory , working memory , perceptual speed , and overall cognitive status were administered in both times.
A battery of neurocognitive / psychological tests was administered to assess the cognitive performance.
A battery of neuropsychological tests was administered to assess the involvement of executive functions in the priming paradigm.
A Bayesian framework for LME models in AD is introduced in this paper to provide additional insight often not found in current LME volumetric analyses.
A Bayesian meta-regression method was used to pool prevalence and derive missing age / sex / region / year values.
Abbreviation : DPN = diabetic polyneuropathy.
ABBREVIATIONS : ANOVA = analysis of variance ; BMI = body mass index ; FT3 = free triiodothyronine ; FT4 = free thyroxine.
ABBREVIATIONS : FSH = follicle-stimulating hormone LH = luteinizing hormone LOH = late-onset hypogonadotropic hypogonadism.
ABBREVIATIONS : Liaison Committee on Medical Education ( LCME ) ; LGBT : Lesbian , gay , bisexual , transgender.
ABCB1 functional activity is affected by TLR4 agonists suggesting that modulation of TLR4 is important in ABCB1 function.
ABCC6 is an efflux transporter primarily expressed in liver facilitating the release of adenosine triphosphate from hepatocytes.
ABCG2 genotype did not affect paracetamol pharmacokinetics.
ABC transporters were shown to be the most important exporter superfamily for toxic peptides , e.g. β-amyloid and α-synuclein.
A BDNF modulating peptide ( Neuropep-1 ) was previously identified by positional-scanning synthetic peptide combinatorial library.
Abdominal aortic aneurysm ( AAA ) and aortoiliac occlusive disease ( AIOD ) are multifactorial vascular disorders caused by complex genetic and environmental factors.
Abdominal aortic aneurysm ( AAA ) and atherosclerosis are common causes of mortality and morbidity in an aging population.
Abdominal aortic calcification score ( AACscore ) was measured by abdominal X-ray.
Abdominal circumference , body weight and blood serum metabolic parameters were determined in the experimental and control groups.
Abdominal debranching and TEVAR were performed as a 2-stage procedure.
Abdominal fat amyloid fibrils in @number@ familial amyloid polyneuropathy patients with amyloidogenic transthyretin Val30Met who had not undergone liver transplantation were examined.
Abdominal fat is the most metabolically active adipose tissue and this provides a clue to potential mechanisms underlying relationships between fat and skeletal muscle.
Abdominal fat was negatively associated with IS and positively correlated with muscle lipid accretion ( both IMCL and EMCL ) , but not with age.
Abdominal sonography showed signs of chronic pancreatitis.
Abdominal surgery under local anesthesia was established in the mice.
Abdominal visceral fat and subcutaneous fat and thigh intermuscular fat and subcutaneous fat were measured by CT.
Abdominopelvic actinomycosis preferentially involves the ileocecal region , ovary , and fallopian tube.
Abdomino-pelvic magnetic resonance showed a @number@ × @number@ × @number@ cm subcutaneous solid mass involving the rectus abdominis muscle.
A behavioral index of attentional alerting served as a marker of phasic arousal.
A bench-to-bedside biomedical research process is discussed that moves through conceptual , basic , translational , and clinical levels.
A beneficial anabolic action of OKG has been demonstrate in several pathological conditions associated with muscle loss.
A benefit of exercise is suggested but not yet conclusively proven.
Aberrant activation of S6 kinase @number@ ( S6K1 ) is found in many diseases , including diabetes , aging , and cancer.
Aberrant angiogenesis and localized inflammation contribute to the formation of CSDH.
Aberrant changes in prostate stem cell regulatory factors may contribute to the development of BPH or PCa.
Aberrant DNA methylation patterns are a characteristic feature of cancer including myeloid malignancies such as acute myeloid leukemia ( AML ) .
Aberrant double-strand DNA damage repair leads to genomic instability and reduced replicative lifespan of somatic cells.
Aberrant expression and localization of APE1 in tumors are recurrent hallmarks of aggressiveness and resistance to therapy.
Aberrant expression of SSTR1 has been implicated in several human diseases , including pseudotumor cerebri , and oncogenic osteomalacia.
Aberrant gene expression patterns underlie many metabolic diseases that represent major public health concerns and formidable therapeutic challenges.
Aberrant hormone levels may represent a compensatory response to the behavioral or neuroanatomical abnormalities of bvFTD.
Aberrant microRNA ( miRNA ) expression might be of potential use as diagnostic and prognostic biomarker for cancers.
Aberrant mitochondrial structure and function influence tissue homeostasis and thereby contribute to multiple human disorders and ageing.
Aberrant neuronal re-entry into the cell cycle is emerging as a potential pathological mechanism in Alzheimer disease ( AD ) .
Aberrant O-mannosylation of α-DG leads to severe congenital muscular dystrophies due to detachment of ECM proteins from the basal membrane.
Aberrant promoter methylation in some tumor suppressor genes is frequent in lung tumors from smokers but rare in those from non-smokers.
Aberrant psychological and behavioral symptoms are common in patients with dementia.
Aberrant Src activation abolished the tumor suppressor activity of LATS1 and induced tumorigenesis in a YAP-dependent manner.
Aberrant Sumoylation of protein ( s ) in response to oxidative stress or during aging is known to be involved in etiopathogenesis of many diseases.
Aberrant TAR DNA protein @number@ immunohistochemistry was seen in @percent@ of hippocampal sclerosis positive patients compared with @percent@ of hippocampal sclerosis negative patients.
Aberrant α-synuclein ( α-syn ) accumulation has been shown to impair mitochondrial function by reducing mitochondrial membrane potential ( MMP ) .
Aberrations control the central peak.
Aberrations in telomere length have been implicated in cancer and aging.
Aberrations were measured with a COAS-HD Hartmann-Shack aberrometer.
Abeta and tau could interfere in an original way contributing to a cascade of events leading to neuronal death and transmitter deficits.
A better comprehension of the mechanisms of decision-making , and of the resulting social consequences of their dysfunction may improve autonomy of the elderly.
A better insight into the mechanisms of epiphyseal fusion may ultimately help to develop new strategies for the treatment of cartilage and growth disorders.
A better knowledge of all possible variations might be helpful in preventing injuries during ALND.
A better knowledge of the genetics of aging will prove helpful in understanding the underlying biological processes.
A better memory for negative emotional events is often attributed to a conjoint impact of increased arousal and noradrenergic modulation ( NA ) .
A better understanding of cholesterol transport mechanisms may lead to the design of potential targets for the prevention of Aβ deposition in the brain.
A better understanding of gender differences in cognition in pathological aging as in health would provide the opportunity to offer a more personalized care.
A better understanding of genetic factors that contribute to cobalamin deficiency in the elderly would allow for targeted nursing care and preventive interventions.
A better understanding of genetic influences on biomarkers like CSF Aβ42 might help to stratify patients and develop specific treatment strategies.
A better understanding of how caspases function in health and disease would provide appropriate specific targets for the development of therapeutic interventions for these diseases.
A better understanding of how such stress affects the body and mind could contribute to the development of more effective clinical interventions and prevention practices.
A better understanding of how these conditions overlap may improve treatment strategies for frail , malnourished , older adults.
A better understanding of its pathophysiology is needed.
A better understanding of mechanisms underlying perinatal programming of adult aging is needed.
A better understanding of pathophysiological mechanisms responsible for those complications is necessary to develop new preventive and therapeutic approaches.
A better understanding of population healthy aging and sex differences in this regard could aid to implement strategies for sustainable healthcare in aging populations.
A better understanding of the basic pathophysiological mechanisms underlying PD would help to advance that goal.
A better understanding of the dual effects of autophagy in ischemia and preconditioning could help to develop new strategies for the preventive treatment of ischemia.
A better understanding of the experience of MCC from multiple perspectives is needed to improve the approach to care for this vulnerable group.
A better understanding of the mechanisms involved in regulating RPE and photoreceptors oxidative stress response is greatly needed.
A better understanding of the mechanisms underlying exercise-induced cardioprotection will lead to the development of innovative pharmacotherapies for cardiac diseases.
A better understanding of the pathophysiology of HIV-related anemia may provide important entry points for improving the chronic manifestations of HIV-related disease.
A better understanding of the patient experience may help to promote exercise initiation and adherence following CAB surgery.
A better understanding of these abnormalities may help in the design of novel and better therapeutic interventions for these patients.
A better understanding of these interactions is needed to understand how to optimize brain remodeling and functional outcome.
A better understanding of these links will help us harness the potential therapeutic benefits of autophagy in combating age-related disorders of the nervous system.
A better understanding of these multifaceted cells will help in developing new treatments to prevent the growth of metastases in uveal melanoma patients.
A better understanding of this complex interrelationship is important in helping the formulation of modalities for a holistic approach to the management of aging men.
A better understanding of this system should broaden concepts of neurodegeneration and facilitate development of effective treatments.
A between-subjects design was used to examine the effect of recent bereavement ( < 2 months ) on neutrophil function in elders.
Ability to predict which patients might benefit more of therapy might facilitate personalization of treatment.
Ability to read music was associated with higher mean scores for both ANT and LMI over time.
Ability to suppress emotions appears to remain stable with age.
A bimodal age distribution of patients with temporal foci was observed.
A binding mode of the inhibitors that is consistent with the SAR data was proposed based on a homology model of SIRT2.
A biobank will be set up.
A Biodex dynamometer was used to record elbow extension torque , position , and velocity.
A Biodex Isokinetic Dynamometer was used to measure knee joint position sense before and after the exercise program.
A bioinformatics analysis identified different molecular pathways to be affected during aging.
A biokinetic model for strontium in humans is necessary for quantification of internal doses due to strontium radioisotopes.
A biotic pattern with homeostatic features ( homeobios ) is generated by combining bipolar feedback with negative feedback.
ABI was analyzed as a dichotomous ( PAD vs. no PAD ) and a continuous measure.
A Bland-Altman plot revealed that there was no systematic bias between aLM and TMM ; however , the other three equations included systematic error.
Ablation of neurogenesis with irradiation abolished the therapeutic effects of fluoxetine.
Ablation with a high-powered CO2 laser offers the advantage of highly precise , hemostatic tissue removal.
Ablative fractional lasers were introduced for treating facial rhytides.
Ablative laser resurfacing still remains the gold standard for treating advanced and severe photoaging providing excellent results in experienced hands.
Ablative skin rejuvenation therapies have limitations for Asian people , including post-inflammatory hyperpigmentation and long down time.
A blepharoplasty / brow lift / ptosis procedure is still frequently required for hooding due to subbrow deflation ( type IV ) .
A blinded assessor and participants evaluated clinical improvement of treatment areas at 1-month follow-up using a quartile grading scale ( 0-4 ) .
A blinded evaluator assessed lateral orbital rhytides at rest and maximal contraction at baseline , @number@ @number@ @number@ and @number@ days post treatment.
A blinded , independent photographs assessment of three dermatologists demonstrated an average reduction of @number@ Fitzpatrick scores ( P < @number@ ) .
A blinded investigator assessed the signs of photodamage.
A blinded radiologist used MRI to measure the temporal , infraorbital , and medial and lateral cheek areas.
Abl inhibition by nilotinib or bosutinib facilitates amyloid clearance and may decrease inflammation.
A block randomisation method was used to randomise participants into case and control groups.
A blood lactate concentration ≥8.0 mmol•L ( @number@ ) excluded @percent@ of the participants in the 50-85-year-old cohort.
A blood sample and a urine sample were taken for routine analyses during follow-up.
A BMI value < 22.2 kg / m2 and a MNA score < 17 were associated with lower survival.
ABM rejected cell inactivation and predicted increased self-renewal would only affect juveniles while dedifferentiation could act in both juveniles and adults.
ABM simulation of population dynamics of double cytokeratin cells supported increased self-renewal in irradiated MCF10A treated with TGFβ.
Abnormal articulation rate is a frequent symptom in neurogenic speech disorders.
Abnormal behaviors comparable to those of human psychiatric disorders such as hyperactivity and poor social behavior were observed in BRINP1-KO mice.
Abnormal changes in these layers have been implicated in diseases such as age-related macular degeneration and glaucoma.
Abnormal copper homeostasis also contributes to AD pathogenesis.
Abnormal CSF-AD biomarker levels predict subsequent progression to AD dementia in subjects with early-onset MCI.
Abnormal EEG background ( particularly suppression ) during neonatal period may be predictive of Unfavorable outcome.
Abnormal epigenetic regulation is a hallmark in many pathological conditions including AD.
Abnormal expression of miR-182 in a variety of human cancers has reported.
Abnormal expression of miRNA is closely related with abnormal wound healing.
Abnormal findings were noted in @percent@ of patients and there was > 90% agreement between the TECS reading and the face-to-face findings of the physician.
Abnormal impulse formation in the pulmonary veins is known to trigger paroxysmal AF and radiofrequency isolation of these veins is recommended in drug-refractory AF.
Abnormalities identified during this period have been recognized as potential predictors of neurodevelopment in children born preterm.
Abnormalities in HMs have been implicated in sudden infant death syndrome ( SIDS ) and obstructive sleep apnoea.
Abnormalities in neuronal function can lead to cognitive , motor , or behavioral disorders during development or aging.
Abnormalities in specific cerebral networks likely confer vulnerability that increases the susceptibility for development of geriatric depression and affect the course of symptoms.
Abnormalities in the development of metaphyseal trabecular bone are likely to influence fragility in both trabecular and cortical bone of this region in adulthood.
Abnormalities were significantly more prevalent among males ( P < @number@ ) .
Abnormal levels of glycated hemoglobin , high-sensitivity C-reactive protein , and high-density lipoprotein were each found in around @percent@ of patients.
Abnormal lipoprotein profiles are associated with breast cancer progression.
Abnormally elevated hippocampal Caspase-6 ( Casp6 ) activity is intimately associated with age-related cognitive impairment in humans and in mice.
Abnormally elevated iron levels have been found in various neurodegenerative diseases.
Abnormally expressed TCR-Vβ subfamilies were generally found in both TIL and peripheral blood lymphocytes ( PBL ) of each patient.
Abnormally high levels of intrinsic formaldehyde lead to dysfunction in cognition such as learning decline and memory loss.
Abnormally increased levels of TDP-43 are detected in patients with amyotrophic lateral sclerosis and a downregulation of NF-L mRNA.
Abnormally small kidneys ( < @date@ of predicted size ) were detected in @number@ ELBW and four control children ( p = @number@ ) .
Abnormal mineral metabolism is a hallmark in patients with advanced chronic kidney disease ( CKD ) .
Abnormal NFκB activation has been implicated in Alzheimer's disease ( AD ) .
Abnormal nutritional conditions such as obesity or malnutrition often manifest themselves by specific cutaneous features and altered skin function.
Abnormal patterns of calcium release and sequestration detected at fertilization in the human appear to have coincident effects on levels of mitochondrial ATP generation.
Abnormal processes were observed as early as post-natal day @number@
Abnormal proliferation and function of MSCs were reported at maternal fetal interface in patients with pre-eclampsia ( PE ) .
Abnormal protein phosphorylation has been associated with several human diseases including Alzheimer's disease ( AD ) .
Abnormal P-wave axis ( aPWA ) was defined as any value outside @number@ to @number@ degrees on study visit 12-lead electrocardiograms.
Abnormal regulation of the FGFR1-Klotho receptor complex may cause a resistance to the phosphaturic action of FGF23.
Abnormal regulation of these factors due to endothelial cell dysfunction is both a consequence and a cause of vascular disease processes.
Abnormal serum lipids were defined according to international criteria and use of hypolipidemic drugs.
Abnormal sleep / CRD in BD was associated with impaired functioning and worse QoL.
Abnormal visual experience during the sensitive period can lead to amblyopia , a developmental disorder of vision affecting ∼3% of children.
A board-certified radiologist , blinded to clinical and laboratory data , measured the duct diameter.
A body mass index ≥25 ( p = 0.016 ) was associated with decreased dermal intensity.
A body of knowledge-both quantitative and qualitative-has developed on the topic of depression in older adults.
A bootstrapped mediation test supported the predicted indirect pathway ( P = 0.003 ) .
A borderline significant association was also found with high fish consumption ( OR Q4 versus Q1 = @number@ CI 95% = 0.63-1.01 ) .
ABO survival curves were compared.
About 20-25% of all persons and about @percent@ of all patients who are acutely hospitalized in internal medicine departments have multiple acute or chronic diseases.
About 80-90% of individuals of both sexes have radiographic evidence of OA by the time they reach an age of @number@
About half of the observers significantly underestimated the distance ratios , while the judgments of the remainder were essentially accurate.
About half of the subjects ( @percent@ ) were naive to BoNT-A treatment of the glabella , while @percent@ had previously received another product.
About half of the world's elderly population live in the developing world.
About half reported walking / using a wheelchair or scooter.
About @number@ JMATs comprising nearly @number@ health workers were launched.
About @number@ nondemented elderly ( age ≥ @number@ ) in New York who provided dietary information at baseline were followed-up prospectively for AD development.
About @number@ obese men ( body mass index ( BMI ) ⩾30 kg m RESULTS : Eighty-two men completed the study.
About @number@ % of the world's pigs originate from such systems , each producing 2-5 head per year.
About @number@ % of this population are members of social health insurances ( SHI ) whose premiums are generally income-related and independent of health status.
About @number@ out of @number@ RCFs had at least one resident who had some or all of their LTC services paid by Medicaid.
About @number@ patients had more than @number@ years of FU , and @percent@ had received @number@ months of androgen deprivation therapy ( ADT ) .
About @number@ people will be visually impaired.
About @number@ percent of cases with tinea pedis is treated only using external preparations.
A bout of unilateral REX was performed during the placebo and Leu treatments.
About one-half of RCFs were small facilities which served one-tenth of all RCF residents.
About @percent@ and over @percent@ showed hearing loss at low and high frequencies , respectively.
About @percent@ definitely wanted to work after age @number@
About @percent@ elderly used any active transport and spent @number@ hours on sedentary activities , daily.
About @percent@ had full and @percent@ had partial EF at baseline.
About @percent@ of < 30-year-old subjects were healthy.
About @percent@ of all cases exhibit signs of frontotemporal degeneration ( FTD ) .
About @percent@ of dentists took regular exercises weekly.
About @percent@ of overweight youth remained overweight as adults , while @percent@ of overweight adults were not overweight youth.
About @percent@ of participants had adverse events from exercise , of which knee pain was the top ranked.
About @percent@ of participants lost at least @number@ pounds during follow up.
About @percent@ of people showed more than one-fold increase of telomerase activity after our MBT program.
About @percent@ of primary care physicians identified themselves as regular smokers.
About @percent@ of RNs reported that they would not be willing to work during a flu pandemic , regardless of incentives or other factors.
About @percent@ of study participants consumed water from wells with F ( - ) levels above the WHO recommended standard of @number@.5mg / l.
About @percent@ of the cases are idiopathic.
About @percent@ of the diabetic sample did not ( re ) fill any diabetes medication and over @percent@ had at least one diabetes complication.
About @percent@ of the falls were reported as serious adverse events and @percent@ were reported to be severe.
About @percent@ of the patients replied that they were either greatly satisfied or satisfied with the results at 3-months follow-up.
About @percent@ of the sample had at least one comorbidity in addition to HIV.
About @percent@ of the sample were food insecure.
About @percent@ of these patients also had concurrent TCM in addition to their other cancer treatments.
About @percent@ of the total number of respondents said they have not so good health status compared to others.
About @percent@ of total body calcium is present in bone.
About @percent@ of white matter alterations variability remains unexplained by the disease-associated determinants.
About @percent@ of younger adults and three quarters of older adults showed both healthy @number@ and @number@ year olds sleep without awakenings.
About @percent@ subjects had total cholesterol in acceptable range while @percent@ had borderline elevated and @percent@ had elevated TC.
About @percent@ to @percent@ of atherosclerotic renal artery stenosis cases lead to the development of resistant hypertension and / or ischemic nephropathy.
About @percent@ were able to manage their activities of daily living without assistance.
About @percent@ were interested in receiving training on cultural competence.
About the same MetS prevalence ( @percent@ ) was found in men , but not in women.
About three-fifths ( @percent@ ) reported that they had at least one symptom of poor mental health.
About three times as many Ae. aegypti mosquitoes were collected in urban than rural sites ( @number@ versus @number@ ) .
About two-third of the QIs focussed on specific disease groups.
About two-thirds of the elderly ( @percent@ ) got sick during the @number@ years preceding the survey.
Above age sixty model estimates of survival for both sexes differed substantially from those observed.
Above all , HepG2 xenografts treated with this combination therapy went into remission.
Above all , use of broad-spectrum antibiotics is highly debated all over the world due to growing antimicrobial resistance.
Above all , we can conclude that client-centered care results in positive outcomes for residents and family members.
Above @number@ min , the specific pattern was always recognizable.
Above the median TPA additional activity was not significantly associated with better survival.
Above the resting potential , ongoing-spontaneous activity was predominantly enhanced due to excessive GABA-uptake from the extracellular space by transporters.
A boy with Pelizaeus-Merzbacher disease underwent repeated evaluations by 3-Tesla ( @number@ ) H-magnetic resonance spectroscopy ( MRS ) .
ABP and MBG in plasma and urine were measured at baseline ( unstandardized salt intake ) and after high and low-salt intake.
ABPV may therefore be an additional target for treatment in older people.
ABPV was calculated using SD and coefficient of variation ( Cv ) .
A brain bank specially for psychiatric disorders was also established in Fukushima University.
A brain-wide analysis approach of functional connectivity in the aging brain thus seems fundamental in understanding how age affects integration of information.
ABR data indicated no statistically significant difference in hearing between treated and untreated mice in both backgrounds.
A brief battery of neuropsychological measures was also administered to assess the convergent and discriminant validity of the FMRI Symbol Search task.
A brief history of hUCB in treatment of an ALS animal model and the feasibility of these cells in therapy for ALS patients is provided.
A brief introduction to Tai Chi Chuan and its related physical benefits is provided.
A brief overview of the literature on anesthetic techniques that may influence geriatric-related syndromes is also presented.
A brief overview of the past , present , and future injectable fillers is presented.
A brief presentation of wearables in one pathological group is presented , identifying appropriate work for researchers in other cohorts to utilise.
A brief questionnaire exploring lifestyle habits , dietary preferences and the consumption of selected foods was administered.
A brief summary of currently available skin-resurfacing techniques is also discussed.
A brief Valsalva manoeuvre , lasting 2-3 s , performed by young healthy men during strength exercise reduces transmural pressure acting on intrathoracic arteries.
A broad consensus now exists that these criteria should be revised to incorporate state-of-the-art scientific knowledge.
A broader spectrum of non-demented elderly control subjects from previous studies was also included for comparison ( N = 423 ) .
A broad range of general cognitive functions such as attention , memory , and intelligence were determined using different neuropsychological tests.
A broad spectrum of tests are available to indentify and monitor the emerging cardiovascular dysfunction.
Abrogating this leaky BBB-mediated inflammation via stem cell therapy represents a paradigm-shifting approach to treating brain cancer.
A broken-stick model consists of two linear parts and a breakpoint where the two lines intersect.
A bronchoscopy and transbronchial lung biopsy ( TBB ) were performed twice ; no evidence of malignancy was found.
Absence of increase in cytoplasm to nucleus ratio index in elderly patients testifies a smaller degree of monocytes activation in this group of patients.
Absence of knee OA was associated with being male.
Absence of statistically significant changes observed in men should however be treated with caution because of the low number of men in the study.
Absence of syncope associated bradycardia during HUT testing predicts for A-LOC.
Absent in youth , the LA emerges during early puberty and becomes more prominent with advancing age.
Absent robust professional initiatives in this area , regulators and legislators may impose more draconian measures.
Absent this commitment device , contributions may be lower for some households than would be the case without a DC loan option.
ABS is a diagnosis of exclusion and its incidence is probably underestimated in elderly patients in whom coronary angiography is not common.
Absolute accuracy was assessed by comparison of the AHRS orientation measurements to those of an optical gold standard.
Absolute and relative accuracy were significantly affected ( p < 0.05 ) by velocity during sustained motions.
Absolute and relative moderate-to-vigorous PA ( MVPA ) thresholds were applied to quantify adherence to PA recommendation.
Absolute concentrations of taurine ( Tau ) and L-glutamine were significantly dominant in these tear fluids.
Absolute differences in life expectancy , healthy life expectancy , and life expectancy with disability according to the number of teeth were also estimated.
Absolute differences were modest.
Absolute gait velocity ( m / s ) was significantly slower for children ; however , there was no effect of age on step length.
Absolute lymphocytes , serum globulins , and mean platelet volume increased linearly with increasing old age.
Absolute number and. rates of elderly people increases permanently and it will be so in the next future.
Absolute percentage error scores , Intraclass Correlation Coefficients ( ICC ) , and Bland-Altman plots were used to assess validity.
Absolute SEM values were found clinically acceptable for the IMF-EMG , but relatively high for the fatigue slope declines.
Absolute stability of strategies varied , indicating that change in coping styles was possible.
Absolute synthesis rates of tissue proteins were independent of the initial inflammatory status , except for liver @number@ days after infection.
Absolute telomere length measurements were performed using polymerase chain reaction methods.
Absolute thickness of the involucrin-positive cellular layer remained practically constant at different ages , while its proportion in the total epidermal thickness uncreased.
Abs significantly increased all CD4-Tm ex-mRNAs , but only IL-2 and IL-6 ex-mRNAs were increased by Aβ.
Abstention related to procedural issues was reported in @percent@ of facilities.
Abstinence and regular daily alcohol consumption were reported in equal ratio.
Abstract.
ABSTRACT : Ageing is associated with marked large artery stiffening.
Abstract : Chronic organic mitral regurgitation resulting from mitral valve prolapse is increasing in prevalence due to aging of the population.
ABSTRACT In the United States , chronic wounds affect @number@ million patients.
Abstract Like most basic molecular mechanisms , programmed @number@ ribosomal frameshifting ( @number@ PRF ) was first identified in viruses.
ABSTRACT : Mitochondrial dynamics proteins are critical for mitochondrial turnover and maintenance of mitochondrial health.
Abstract Objective.
ABSTRACT : Older adult patients may present to skin and wound care clinicians with skin injuries as a result of falls.
Abstracts of annual meetings of the Endocrine Society and American Society for Reproductive Medicine were also reviewed.
Abstract Survival for patients with multiple myeloma has increased during the first decade of the 21st century.
Abstract Testosterone replacement therapy is often equated with the macho male physique and virility and is viewed by some as an antiaging tonic.
Abstract The article reviews the major biological theories of aging , and discusses the most relevant mechanisms to explain the aging process.
ABSTRACTThe hidden nature of older adult mistreatment renders its detection in the domestic setting particularly challenging.
Abstract The immune system of an organism is an essential component of the defense mechanism aimed at combating pathogenic stress.
ABSTRACTThis article presents two studies dealing with ageism.
ABSTRACTThis study was aimed at providing normative data for the Mini-Mental State Examination ( MMSE ) .
( ABSTRACT TRUNCATED ) .
Abundant 8-oxo-dG in DNA exhibits genotoxicity and has been linked to aging and disease , such as cancer.
Abundant evidence shows that the 20S proteasome is largely responsible for degradation of oxidative proteins in both ubiquitin-dependent and ubiquitin-independent pathways.
Abundant proteins of the Aβ42 peptide-generating system in ADEs may sustain levels in neurons.
Abundant tau-related pathology was observed in the cortex and striatum of all cases studied.
Abuse rate of the older people and their caregivers is both high and similar.
Abuse was associated with heightened IL-6 and TNF-α levels ; for TNF-α , this relationship was magnified in caregivers compared with controls.
Academic performance was controlled for using the United States Medical Licensing Exam Step @number@ exam scores.
Academic Search Premier , MEDLINE , CINAHL Plus , and PsycINFO databases were searched.
Academics , policy makers and practitioners should consider the approach of appreciative action research as key to supporting developments in care.
ACA is more likely than EM to be localized anatomically to the extremities.
A calculator is supplied for point-of-care use , which automatically replicates the frailty classification for any given measurements.
A candidate drug screen identified the c-Met inhibitor SU11274 for further analysis.
ACA patients were also significantly older than patients with Lyme neuroborreliosis or Lyme arthritis ( p < 0.001 ) .
Acarbose attenuates the fall in blood pressure ( BP ) induced by oral sucrose and may be useful in the management of postprandial hypotension.
A careful and reasonable use of drugs in the elderly is also of importance.
A caring , attentive FP who monitors depressed patients is likely to have considerable placebo effect.
A CART analysis identified factors discriminating best between institutionalized and non-institutionalized individuals.
A case-crossover design was used to compare monthly Medicare expenditures before and after sentinel injury events.
A case example is used to illustrate these points.
A case of a patient with a three days lasting erythema on both lower eyelids caused by laser therapy healed without any pharmacological therapy.
A case report on high levels of sodium and potassium in patients with hyperthyroidism is presented.
A case study is used to illustrate these phenomena.
A case vignette describes the challenges and rewards of therapy with an elder trans woman.
Acatalasemia means the inherited near-total deficiency of catalase activity , usually in reference to red cell catalase.
Acatalasemia was thought at first to be an asymptotic disorder.
A causal role for copy number variation ( CNV ) in the prion protein gene ( PRNP ) in prion dementias is not known.
Accelerated ageing of immune cells ( immunosenescence ) appears to be a major mechanism favouring the disruption of tolerance.
Accelerated aging hypothesis is supported based on frontal regions and peripheral studies ; however , further studies are needed in other brain regions.
Accelerated aging in cognitive control or subcortical gray matter was not supported in SBM.
Accelerated aging of the brain and increased risk of early onset dementia are suspected after CRT , but not after CT.
Accelerated aging of the immune system ( immune aging ) , represented by telomere shortening , has been implicated in a variety of rheumatic diseases.
Accelerated aging syndromes represent a valuable source of information about the molecular mechanisms involved in normal aging.
Accelerated biological aging , reflected in shorter leukocyte telomere length ( LTL ) , may underlie these risks.
Accelerated by chronic sun exposure , fundamental changes occur within the dermal extracellular matrix over the years , mainly impairing the collagenous network.
Accelerated cellular aging , as indexed by telomere attrition in immune cells , is a plausible pathway linking sleep and disease risk.
Accelerated infant growth until @number@ months was associated with narrow retinal arteriolar caliber , especially among preterm-born children ( P < @number@ ) .
Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders , including schizophrenia and mood disorders.
Accelerated loss of muscle strength is a potential mediator in the disabling effect of diabetes.
Accelerated progression of WMH is linked with mortality risk in old age.
Accelerated senescence of epithelial cells plays a role in IPF pathogenesis by perpetuating abnormal epithelial-mesenchymal interactions.
Accelerated shortening of telomeres was detected in osteoarthritis and other age-related diseases.
Accelerated telomere loss has been associated with many chronic diseases of aging.
Accelerated telomere reduction was seen in tolerated grafts compared with the predicted telomere length of each allograft calculated from the regression line of donor livers.
Accelerating of population aging in Saint-Petersburg and Russia leads to a new demographic situation requiring a number of economic and socially oriented measures.
Acceleratory growth was found both in tension and compression phases proving that VEP growth followed principles of CGFRC rather than HVL.
Accelerometer assessed MPA , VPA and MVPA were analyzed using absolute and relative thresholds.
Accelerometer data were adjusted to a pedometer scale using an established process of censoring steps counted during those minutes where activity counts totaled < 500.
Accelerometer data were then analyzed using both frequency- and time-domain analyses.
Accelerometer measured sedentary time , light-intensity , and moderate-to-vigorous physical activity improved ( all p values ≤ @number@ ) .
Accelerometer outputs as peak loading ( g ) per activity were averaged.
Accelerometers can record quasi-continuous activity information for many days and for hundreds of individuals.
Accelerometry counts were log-transformed and mean log-counts were used to derive a summary variable indicating total daily log-activity counts.
Accelerometry data acquisition was performed for @number@ first-time poststroke patients during a reach-press-return task.
Accelerometry has the potential to explore the role of walking in older patients in rehabilitation.
Accentuated kyphosis is associated with adverse health outcomes , including falls and fractures.
Acceptability ( adherence and satisfaction ) was high.
Acceptability and potential effectiveness were studied in a pilot study with a pre- / postdesign in which @number@ physical therapists and @number@ patients participated.
Acceptability and usability were reported descriptively.
Acceptability was ascertained by questionnaire and a @number@ mm pain Visual Analogue Scale ( VAS ) .
Acceptability was assessed through the use of the Simulator Sickness Questionnaire pre- and postexposure to assess possible side effects of the visual-vestibular conflict.
Acceptability was good.
Acceptable to good person separation and reliability statistics supported the clinical applicability and consistency of the HELP scores.
Acceptance for functional dairy products increases among consumers with higher diet / health related knowledge , as well as with aging.
Acceptance is paramount for LGBT seniors and social networks expanded , contrary to socioemotional selectivity theory.
Accepted the theory of L. Hayflick he evaluates the aging process in frame of an evolution model.
Accepting delegation to administer medications has become an implicit prerequisite for social care work in the municipality.
Accessibility by phone did not meet the expectations of the interviewees.
Accessibility to non-statisticians , based on its close relationship to the normal distribution.
Accessible information about products and services is of crucial importance to ensure that all citizens can participate fully as active members of society.
Accessing timely acute medical care is a challenge for older adults.
Accessing traditional audiology services for hearing loss is a challenge because of high cost and time commitment.
Access to affordable healthy food and transportation were identified as the major barriers to eating healthfully and navigating their neighborhood food environments.
Access to health care may not attenuate wealth-associated disparities in older adults.
Access to health services shows increasing inclusion in primary care.
Access to these data will facilitate discovery of mechanisms of miRNA regulation of gene expression.
Access was provided by the contribution of the Geographical Post Office for each province.
Accident risk factors ( e.g. , adverse weather , geographical region , post-impact fire , gender differences ) will be discussed.
AC click- and BC tone burst-evoked oVEMPs showed a significant decline with age.
Accommodative changes support the Helmholtz theory of accommodation including an increase in posterior lens surface curvature.
Accommodative responses were measured sequentially by the WAM @number@ Auto Ref / Keratometer ( Grand Seiko , Hiroshima , Japan ) .
Accompanying documented and freely available simulation model facilitates diverse applications customized to different sub-populations.
Accompanying policy efforts provide the necessary support needed to increase access to care significantly.
Accompanying the ageing of contemporary ageing societies is an increase in age associated morbidity , with dementia having an important impact.
Accorded dietary habits provide adequate nutrient intakes , especially important for quality aging.
Accordingly , A1R stimulation by the agonist 2-chloro-N Human beings are subjected to aging and age-associated diseases.
Accordingly , ACPs have potential for nutraceuticals as anti-skin-photoaging ingredients.
Accordingly , a few clinical trials have evaluated the efficacy of antioxidants on visual and cognitive performance in patients presenting both disorders.
Accordingly , age is a critical determinant of outcome for hepatitis C virus infection and liver transplantation.
Accordingly , aging males are likely to benefit more from medical treatment.
Accordingly , a large number of measures are now available to quantify social cognitive function.
Accordingly , analysis of the gene pathways involved in hematopoiesis regulation showed that BM-A are more closely related to BM-MSC than to AT-A.
Accordingly , ANK1 polymorphisms might contribute to late-onset AD ( LOAD ) risk.
Accordingly , antimicrobial stewardship ( AMS ) programs have started to be introduced into the residential aged care facilities setting to promote judicious antimicrobial use.
Accordingly , assessment of LV dysfunction can be employed as a surrogate marker of cardiac age.
Accordingly , a strong correlation in ANM is observed between mothers and daughters.
Accordingly , circadian arrhythmia profoundly affects stem cell function in culture and in vivo.
Accordingly , clinicians play an important role in educating and promoting beneficial actions to preserve cognitive function.
Accordingly , cognitively healthy subjects at risk for AD often have altered CSF concentrations of Aβ1-42 and pTau181.
Accordingly , compared to wild-type BMI1 , mutant protein exhibited increased pro-oncogenic activity.
Accordingly , CSPalpha upregulation also occurs in a mouse model of tauopathy only at time when neuronal loss does not take place.
Accordingly , different interventions may be necessary when helping older adults exposed to ongoing versus intense time-limited trauma.
Accordingly , DJ-1-deficient mice develop glucose intolerance and reduced β cell area as they age or gain weight.
Accordingly , elevated serum Lp ( a ) concentrations may be compatible with longevity.
Accordingly , EVs have been the focus of intense investigation as biomarkers of disease , prognostic indicators , and even therapeutic tools.
Accordingly , failure to address changes in the skeletal foundation of the face may limit the potential benefit of any rejuvenation procedure.
Accordingly , functional studies demonstrated mitochondrial dysfunction in HGPS fibroblasts.
Accordingly , G2-arrest , and cellular senescence largely dependent on p21 were substantially abrogated.
Accordingly , H3K9me3-marked heterochromatin gets remodelled at the perinucleolar space as revealed by immunofluorescence analyses.
Accordingly , heterogeneous biological effects can be added to the classical effects on mineral bone metabolism.
Accordingly , hypertrophic adipocytes become overburdened with lipids , resulting in changes in the secreted hormonal milieu.
Accordingly , IL-15 induced an identical pattern of CD69 expression in peripheral blood CD4 ( + ) and CD8 ( + ) T cell subsets.
Accordingly , increased levels of β-amyloids were also observed in AD mice.
Accordingly , incretin-based agents have an advantage because they are unlikely to cause hypoglycemia.
Accordingly , in elderly patients , body mass index ( BMI ) is considered a marker of protein stores rather than of adiposity.
Accordingly , inhibition of CerS6 or its specific knockdown diminished the increased susceptibility of COX-deficient cells to oxidative stress.
Accordingly , isometric tension did not differ between patients and controls in MHC I or IIA fibres.
Accordingly , it is believed that IGF-1 plays a central role in IVD homeostasis.
Accordingly , Klotho protein is a powerful regulator of transport mechanisms across the cell membrane.
Accordingly , life expectancy with type @number@ diabetes increased in both women and in men.
Accordingly , low EZH2 or MUS81 expression levels predict chemoresistance and poor outcome in patients with BRCA2-mutated tumours.
Accordingly , management of hypertension and its long-term complications in HIV-infected subjects is a significant component of routine care.
Accordingly , miRs might represent promising targets for the prevention of vascular calcification and its adverse cardiovascular sequelae.
Accordingly , molecular chaperones , the ubiquitin-proteasome system ( UPS ) and autophagy together promote refolding or clearance of misfolded proteins.
Accordingly , older patients with colorectal cancer with senile kyphosis caused by aging or osteoporosis also increase.
Accordingly , p66 ( shc ) knockout animals are one of the best characterized genetic model of longevity.
Accordingly , patients with pyogenic spondylitis have been increasing and may present atypical clinical features.
Accordingly , pharmacological inhibition of EGFR and AKT recapitulated detrimental effects caused by shRNA-mediated depletion of α5.
Accordingly , pharmacological inhibition of the proteasome led to decreased mitochondrial function , whereas inhibition of mitochondrial function in turn reduced proteasome activity.
Accordingly , PINK1 deficiency is associated with mitochondrial dysfunction as well as increased oxidative cellular stress and subsequent neuronal cell death.
Accordingly , plant extracts with antioxidant properties are beneficial cosmetic ingredients for this purpose.
Accordingly , RAMs and CAs may exist simultaneously in hypertensive patients.
Accordingly , scale invariance can be a potential marker for health.
Accordingly , several studies showed that vascular calcification is associated with increased risk for cardiovascular morbidity and mortality.
Accordingly , siblings of centenarians have a dramatically higher probability of reaching extreme old age than the general population.
Accordingly , silencing of ZMPSTE24 reduces human cancer cell invasiveness.
Accordingly , Sirt4 overexpression in wild-type TSCs recapitulates the senescence phenotype initiated by Lsd1 deletion or inhibition.
Accordingly , skeletal aging and aging-related bone diseases are also associated with accumulation of reactive oxygen species.
Accordingly , specific influencing factors relevant for perioperative management can be increasingly more identified.
Accordingly , strategies to promote cardiovascular health , especially if implemented from early life , might help to delay the onset of dementia.
Accordingly , synergism has been observed between DNA-damaging drugs and targeted inhibitors of DNA repair.
Accordingly , T-cell-specific deletion of Smad4 was sufficient to suppress the progression of melanoma.
Accordingly , the alteration of aging bears the promise of harnessing the mechanisms that protect the young organism to prevent illness in the elderly.
Accordingly , the assessment of PD in elderly patients needs information of the respective vast areas.
Accordingly , the biological principles of arterial aging , as expressed in pulse pressure , are the same in all humans , regardless of demography.
Accordingly the blockade of either TGFβ signaling or DNMT1 / 3a activities significantly recovered the Klotho loss and attenuated pro-fibrotic protein expression and renal fibrosis.
Accordingly , the current study examines whether associations of inflammation with cognitive function are mediated by variation in cortical gray matter volume among midlife adults.
Accordingly , the IL-4 @number@ T allele may be applied as a protective marker in the development of LOAD in Iranian population.
Accordingly , the implications of aging and atrophy on lure discrimination capacities are discussed.
Accordingly , the possibility exists that the causal factors for these conditions may be very similar.
Accordingly , the present proposals on specific solutions were designed.
Accordingly , the research interest is focused on understanding the biological mechanisms involved in determining the positive ageing phenotype , i.e. the centenarian phenotype.
Accordingly , the responses to TGF-β1 shown by promoter assay and plasminogen activator inhibitor type @number@ expression were significantly attenuated in VASH2 knockdown cells.
Accordingly , these findings demonstrate that persons in same-sex cohabiting partnerships require unique policy considerations to address health and economic concerns in old age.
Accordingly , the use of antioxidant nanoparticles / nanomaterials is burgeoning in biomedical , pharmaceutical , cosmetic , food and nutrition fields.
Accordingly , this article sets out to detail the specific technique for safe and effective lipoharvesting for facial fat transfer.
Accordingly , this study examines the association of neuromuscular activation rate with muscle performance in persons of different age and mobility function.
Accordingly , tweaking ageing might be an attractive approach to prevent cognitive decline caused by age-related synaptic dysfunction.
Accordingly , we administered testosterone with and without α-difluoromethylornithine ( DFMO ) , an Odc1 inhibitor , to castrated mice.
Accordingly , we aimed to estimate the risk of incident atrial fibrillation in this population.
Accordingly , we aimed to investigate the accuracy of the current cut-off value in an elderly population.
Accordingly , we characterized the relationship of plasma CNP with LV fibrosis and function in 2- , 11- , and 20-month-old male Fischer rats.
Accordingly , we detected Gal-8 in human cerebrospinal fluid , suggesting a role in the CNS immune-surveillance circuit.
Accordingly , we propose that multiple-modality training provides a sufficient intervention to improve executive control in persons with a SCC.
Accordingly , we tested the hypothesis that volunteering moderates the relation between functional limitations and risk of mortality.
Accordingly , yCAR-T demonstrated higher levels of tumor antigen-specific cytotoxicity compared with gCAR-T.
According to analysis of covariance , the ADL development over time until follow-up @number@ months after hospital discharge did not depend on nutritional status.
According to another , myocardium can renew at a high rate due to the presence of resident stem cells.
According to a @number@ national survey , @number@ % of adults in China have diabetes , affecting @number@ million individuals.
According to ASTM standard , 1-h aging under these conditions corresponds approximately to @number@ yrs in vivo exposure.
According to centrality measurements , @number@ proteins were designated as pivotal elements in AD mechanisms.
According to clinical diagnosis , the study population was divided into @number@ MS ( cases ) versus @number@ no MS ( controls ) patients.
According to CPITN index , better-educated participants had more healthy sextants , but they also had more sextants with periodontal pockets.
According to EORS , sedentary behavior associated with age triggers an oxidized redox shift and impaired mitochondrial function.
According to Erik Erikson's theory on the stages of human development , achieving wisdom later in life involves revisiting previous crises and renewing psychosocial accomplishments.
According to Globocan estimates , the top most common cancers in both sexes are breast , non-Hodgkin lymphoma , leukemia , esophagus , and colorectum.
According to hundreds of years of legend , it was founded in @number@ year.
According to inclusion criteria , @number@ octogenarians were enrolled.
According to inhibitory deficit theory , older adults should be more impaired by auditory distractors.
According to many studies , a U-shaped curve prevails for the effect of serum calcidiol concentration on the relative risk of morbidity and mortality.
According to mitochondrial theory of ageing the ageing process results from accumulation of mitochondrial DNA ( mtDNA ) damage.
According to mitochondrial theory of aging , mitochondrial dysfunction is widely considered a major contributor to age-related processes.
According to @number@ transrectal ultrasound-guided prostatic biopsies performed from @date@ to @date@ , @number@ patients , responding to our inclusion criteria , were selected.
According to our data , saccade characteristics depend upon age in both healthy subjects and parkinsonian patients.
According to our findings , it may be important to offer Web- and print-based materials alongside each other.
According to our results , all of Germany can be considered as an endemic area for SFGR.
According to our results , blepharoplasty seems not to cause significant changes in the main corneal indices.
According to our satisfaction survey , all patients had cosmetic improvement.
According to positive correlation between spiritual well-being and quality-of-life scores , awareness of the importance of spiritual well-being in caring of these people is recommended.
According to previous studies , Aβ might share perforating properties with gramicidin , a well-accepted membrane-disrupting peptide.
According to prominent theories of aging , the brain may reorganize to compensate for neural deterioration and prevent or offset cognitive decline.
According to rapid aging of society , the peak age of ACS onset has grown older globally.
According to recent studies , stem cells are found in various tissues in our bodies.
According to some , lactate is a preferred fuel for brain metabolism.
According to statistics , the Republic of Serbia is one of the countries with the majority of the elderly.
According to terror management theory , awareness of death affects diverse aspects of human thought and behavior.
According to terror management theory , people are motivated to protect themselves from the potential for anxiety resulting from awareness of mortality.
According to terror management theory , people are motivated to protect themselves from the potential for anxiety resulting from awareness of mortality.
According to the American Society for Aesthetic Plastic Surgery ( ) , the number of nonsurgical treatments grew @percent@ from @number@ to @number@
According to the amyloid hypothesis , amyloid β accumulates in brains with Alzheimer's disease ( AD ) and triggers cell death and memory deficit.
According to the anamnesis , subjects were divided into two groups : experimental group ( EG ) and control group ( CG ) .
According to the APOE E4 status , all participants were classified as non-carriers , heterozygotes , or homozygotes.
According to the ARI , most groups demonstrated adhesive failure.
According to the BAROS method appliance the patients showed excellent , very good and good classifications and , none of them was classified as insufficient.
According to the Beers criteria , @number@ ( @percent@ ) of the medications were potentially inappropriate.
According to the binding affinity test , highly likely potential contaminants were found more frequently on AA samples.
According to the both BMI classification criteria , the group with higher BMI had higher level of SUA ( p < 0.001 ) .
According to the BST , a pathological condition is a state of statistically species-subnormal biological part-functional ability , relative to sex and age.
According to the cognitive status , the patients were divided into two groups , a case group and a control group.
According to the Committee for Advanced Therapies , amniotic stem cells were classified as an advanced therapy medicinal product.
According to the current guidelines , patients underwent endovascular aneurysm repair ( EVAR ) each time the aortic anatomy was suitable.
According to the data , the immigrants tend to remain in Brazil , thus resulting in an aging process in the group.
According to the DSM-IV-TR , @percent@ of individuals had delirium.
According to the earliest entries of the term in the Oxford English Dictionary , events can have good or bad success.
According to the Epworth scale , @percent@ were determined to have Normal daytime sleepiness , and @percent@ were found to have Abnormal daytime sleepiness.
According to the existence of self-reported food problems significantly more people are in subject group.
According to the experts , older patients with ASD , form a specific group in psychiatry.
According to the facial-wrinkle-scale ( FWS ) patients were rated as responders with an improvement of at least @number@ point in FWS.
According to the FISI , the most frequent type of defecation was liquid stool ( @percent@ ) .
According to the frequency of its usage , DRG reimbursement , and position papers , TAVI procedures seem to be established.
According to the Fried frailty criteria , the prevalence was @percent@ for non-frail individuals , @percent@ pre-frail and @percent@ frail.
According to the International Diabetic Federation ( IDF ) criteria , metabolic syndrome was diagnosed in @number@ subjects.
According to the International Working Group-1 criteria , @number@ ( @percent@ ) subjects had prodromal Alzheimer's disease.
According to the International Working Group-2 criteria , @number@ ( @percent@ ) subjects had prodromal Alzheimer's disease.
According to the Laroche list , @percent@ of residents ( n = @number@ ) received at least one PIM.
According to the latest demographic forecast in Poland is observed the progressive aging of the population with growing population of perimenopausal women.
According to the latest recommendations , adults should exercise regularly at moderate intensity to improve aerobic fitness and body composition.
According to the literature , ageing causes declines in sensory , perceptual , motor and cognitive abilities.
According to the mechanism of action , the studies revealed a dose- and time-dependent increase in the viability of human osteoblasts.
According to the MNA , @percent@ were malnourished , @percent@ were at risk for malnutrition , and @percent@ were well nourished.
According to the new proposed cut-points for growth hormone and cortisol , we had @percent@ of normal growth hormone and @percent@ of normal cortisol responses.
According to the numerical relationship between VCmax and FVC , two groups were divided : VCmax > FVC and VCmax = FVC.
According to the participants , LUTS adversely affect the physical aspects of their daily lives.
According to the PBF , @percent@ of the elderly women were classified as eutrophic , @percent@ overweight , and @percent@ obese.
According to the peak and decline model divergent thinking declines at a specific age ( in or after middle age ) .
According to the prevailing theory , aging is accompanied by a continuous and progressive decline in mitochondrial metabolic activity in cells.
According to the report , there were over @number@ excess beds throughout Japan with Akita Prefecture having approximately @number@ extra beds.
According to the results from a microRNA PCR Array , miR-124 was the microRNA that increased the most in senescent skin compared to young skin.
According to the selection standard , @number@ articles were identified and analysised by STATA @number@ software.
According to these results , age and education were considered in the development of the normative data of the MMSE for the Portuguese population.
According to the TiGER database , a tissue origin was established for @number@ proteins and identified @number@ processes in which they participate.
According to the WHO , the worldwide prevalence of obesity nearly doubled between @number@ and @number@
According to this hypothesis , a few studies have shown that elderly tend to exhibit a rightward attentional bias in line bisection.
According to this model , lens growth continues throughout life , but after @number@ years , age-related thickness variations are lower than statistical variability.
According to this @percent@ reduction by annual physiologic aging , DDF was quantitated as E'-E ' norm.
According to this theory , we can manage the aging process by controlling calories or reactive oxygen species.
According to this view , life is a fabric of chemical reactions that sustain each other.
Accountability , enacted as counting and documenting , led to an \ "avalanche of paperwork \ " that took time away from care.
Accounting for lifestyle , sociodemographic , somatometric factors and , subsequently , for medical history explained only a modest amount of the unadjusted associations.
Accounting for physical morbidity and mental well-being reduced group differences in TNF-α and IL-6 levels , respectively.
Accounting for sex did not bring any significant improvements.
Accounting for stroke or competing risk by death marginally modified the results.
Accounting for such diseases is a necessary step for gaining a view of health in the elderly.
Accounting for these child characteristics reduced the status group difference to nonsignificance.
Accounting for total amount of lifetime smoking , the cortex of subjects who stopped smoking seems to have partially recovered for each year without smoking.
Accounts described dealing in the immediate recovery period with unexpected job changes and resultant work uncertainty.
Accrued damaged molecules in cells may either induce cellular death or contribute to develop various pathologies.
Acculturation may play a role in service uptake.
Acculturation parameters were inconsistently associated with help-seeking and service acceptability.
Accumulated DNA lesions cause genomic instability which eventually results in tumorigenesis.
Accumulated evidence thus far seems to indicate that catechins help prevent neurodegeneration and delay brain function decline.
Accumulated oxidative damage accelerates aging ; enhanced antioxidant capacity may be a positive factor for longevity.
Accumulated oxidative exposure has also been proposed as one of the potential hallmarks of the physiological / pathophysiological aging process.
Accumulating data suggest that EGCG possesses important antioxidant and photoprotective properties.
Accumulating data suggest that microRNAs ( miRs ) play an important role in vascular calcification.
Accumulating data suggest that the interaction between the N- and the C-terminal domains in the protein may be the main pathologic feature of apoE4.
Accumulating epidemiological and experimental studies have confirmed that a high-cholesterol diet is detrimental to cognitive performance in animal models.
Accumulating evidence also suggests that ER stress may have important roles in the pathogenesis of inflammatory myopathies and genetic muscle disorders.
Accumulating evidence has indicated that the light source emitted from light-emitting diode ( LED ) has a potential anti-aging effect on human skin.
Accumulating evidence , including brain imaging and postmortem and genetic association studies , has implicated myelin impairments in Alzheimer's disease ( AD ) .
Accumulating evidence indicates a connection between these two diseases at the molecular level.
Accumulating evidence indicates many brain functions are mediated by epigenetic regulation of neural genes , and their dysregulations result in neuronal disorders.
Accumulating evidence indicates that aging is associated with a chronic low-level inflammation , termed sterile-inflammation.
Accumulating evidence indicates that genetic risk of schizophrenia may contribute to cognitive dysfunction.
Accumulating evidence indicates that misfolded proteins are generated in the endoplasmic reticulum ( ER ) by most cataractogenic stresses.
Accumulating evidence indicates that senescent cells play an important role in many age-associated diseases.
Accumulating evidence indicate that arterial stiffness and bone demineralization might share common pathways.
Accumulating evidence suggest a crucial role of progranulin in maintaining proper lysosomal function during aging.
Accumulating evidence suggests a potential link between gene expression , chromatin structure , non-coding RNAs , and cellular differentiation during ocular development.
Accumulating evidence suggests than neuroinflammation plays a critical role in the pathogenesis of both depression and chronic pain.
Accumulating evidence suggests that AD is associated with a microglial dysfunction.
Accumulating evidence suggests that alterations in protein synthesis are not merely a corollary but rather a critical factor for the progression of ageing.
Accumulating evidence suggests that dysregulated or reduced autophagy is associated with heart failure and aging.
Accumulating evidence suggests that physical activity may be beneficial in preserving cognition in late life.
Accumulating evidence suggests that the senescence-messaging secretome ( SMS ) factors released by senescent cells play a key role in cellular senescence and physiological aging.
Accumulating evidence suggest that the pyridine nucleotide NAD has far wider biological functions than its classical role in energy metabolism.
Accumulating recent findings have revealed a prominent role of SUMOylation in molecular pathways that govern senescence and ageing.
Accumulating research has shown that chronic D-galactose ( D-gal ) exposure induces symptoms similar to natural aging in animals.
Accumulation and aggregation of amyloid-β ( Aβ ) in the brain is an initiating step in the pathogenesis of Alzheimer's disease ( AD ) .
Accumulation and incidence rates of multimorbidity outcomes were developed by selecting at-risk subsets of individuals from three large cohort studies of older individuals.
Accumulation of 7-ketocholesterol ( 7KCh ) in tissues has been previously associated with various chronic aging diseases.
Accumulation of adversity tended to intensify with increase in number of diseases and older age , though this finding was not consistently supported.
Accumulation of amyloid-β , a histopathological finding in Alzheimer's disease , is a likely contributor.
Accumulation of amyloid β ( Aβ ) may contribute to synapse dysfunction and memory impairment in AD.
Accumulation of amyloid-β ( Aβ ) peptides correlates with aging and progression of Alzheimer's disease ( AD ) .
Accumulation of brain iron has been suggested as a biomarker of neurodegeneration.
Accumulation of chronic disease further reduces capacity.
Accumulation of DNA damage has been linked to the process of aging and to the onset of age-related diseases including diabetes.
Accumulation of exhausted HCV-specific T cells during chronic infection results in considerable loss of protective functional immune responses.
Accumulation of fragmented collagen fibrils prevents neocollagenesis and accounts for the further degradation of the extracellular matrix by means of positive feedback regulation.
Accumulation of genome rearrangements is a characteristic of aged tissues.
Accumulation of H3.3 is associated with profound changes in global levels of both individual and combinatorial H3 methyl modifications.
Accumulation of HMGB1 at sites of oxidative DNA damage can lead to repair of the DNA.
Accumulation of hyperphosphorylated and aggregated microtubule-associated protein tau ( MAPT ) is a central feature of a class of neurodegenerative diseases termed tauopathies.
Accumulation of lamin A ( LMNA ) was previously associated with the osteoarthritis ( OA ) chondrocyte phenotype.
Accumulation of microtubule-associated protein tau has been observed in the brain of aging and tauopathies.
Accumulation of misfolded , oxidatively damaged proteins is characteristic of many diseases and during aging.
Accumulation of molecular damage and increased molecular heterogeneity are hallmarks of photoaged skin and pathogenesis of human cutaneous disease.
Accumulation of more personal-history risks predicted faster Pace of Aging.
Accumulation of neurodegenerative abnormalities was related to poor memory and executive functions as well as larger WML volumes but not elevated Pittsburgh compound B retention.
Accumulation of oxidized proteins is a hallmark of cellular and organismal aging.
Accumulation of protein aggregates can also be induced from a variety of stressful conditions , such as temperature increase or oxidative stress.
Accumulation of regional WMSA is linked to time to AD conversion in individuals with MCI.
Accumulation of risk across the life course was also evaluated.
Accumulation of senescent cells contributes to the reduced regenerative capacity in aged tissues.
Accumulation of senescent cells occurs with organismal aging and through continual culturing in vitro.
Accumulation of such debris results in cellular dysfunction and is observed in aged tissue and senescent cells.
Accumulation of such lesions in cells may unfavorably affect the functions of tissues and organs , leading to pathologies oreath of the organism.
Accumulation of the mutant WRN at the site of laser-induced DSBs occurred with the same kinetics as wild type WRN in live HeLa cells.
Accumulation of the transactive response DNA-binding protein @number@ ( TDP-43 ) is a major hallmark of several neurodegenerative disorders , collectively known as TDP-43 proteinopathies.
Accumulation of tissue macrophages is a significant characteristic of disease-associated chronic inflammation , and facilitates the progression of disease pathology.
Accumulation of toxic amyloid-β ( Aβ ) in the cerebral cortex and hippocampus is a major pathological feature of Alzheimer's disease ( AD ) .
Accumulation was observed in the mass but not in other regions.
Accuracy for Match pairs declined at a steeper rate than No Match pairs in both groups as SNR decreased.
Accuracy for prediction of these outcomes was investigated using area under the curve ( AUC ) statistics.
Accuracy increased , and response times decreased with more acoustic detail.
Accuracy of dry eye diagnosis by FD-ASOCT was approximately @percent@ , and the clinical diagnostic critical point became lower with increasing age.
Accuracy of macroscopic finding is corrected or revised with microscopic findings and finally compared with neuroimaging and clinical diagnosis.
Accuracy of prediction and applicability are required of an optimal set of commonly assessed biomarkers to provide information on the health status.
Accuracy of response was calculated for Bed-time and Rise-time , determined by light , movement , and diary data.
Accuracy of this assay was validated by recovery test and absorption test.
Accuracy on the serial recall task was poorer for older than for younger adults , and response times were slower.
Accuracy was defined as a difference not significant to zero ( P < 0.05 ) .
Accuracy was good across the cohorts ( Harrell's C statistic : CHS , @number@ FHS , @number@ HRS , @number@ SALSA , @number@ ) .
Accuracy was lower for older adults in both experiments.
Accurate and easy-to-use methodology to quantify protein maldigestion is lacking in CF.
Accurate and reliable measures of functional status are needed to investigate this further.
Accurate and robust brain extraction is a critical step in most neuroimaging analysis pipelines.
Accurate assessment of IGF1 concentrations requires age and sex-matched control values.
Accurate assessment of LBM may allow for more accurate drug prescribing.
Accurate assessment of renal function is necessary for appropriate drug dosage.
Accurate assessment of their intakes is important in the understanding of their individual roles in eye health.
Accurate clinical assessment of ARHL starts with the differentiation between peripheral and central components.
Accurate diagnosis of MD is of crucial significance for epidemiological purposes and for preventive and therapeutic strategies.
Accurate discrimination among aMCI subtypes ( sd- or md-aMCI ) and controls could assist in predicting future decline.
Accurate estimation of the time of menopause could improve the preventive management of women's health.
Accurate evaluation of pathophysiology between the two diseases and appropriate intervention are necessary to improve the prognosis of patients with the diseases.
Accurate identification of new antioxidant proteins is important in understanding their roles in delaying aging.
Accurate in vivo quantification of erythrocyte turnover and its contribution to CF-LVAD complications have yet to be elucidated.
Accurate lower limb somatosensation may play a critical role in narrow-based walking.
Accurately detecting pain requires reliable and resident-adapted means of assessment.
Accurately recovering the hippocampal shapes against rough and noisy segmentations is as challenging as achieving good anatomical correspondence between the individual shapes.
Accurately , the risk of frail condition ( not pre-frail ) increases about @percent@ per second spent in this test.
Accurate measurement of repertoire diversity remains an experimental challenge.
Accurate memory retrieval from partial or degraded input requires the reactivation of memory traces , a hippocampal mechanism termed pattern completion.
Accurate methods to assess the pathogenicity of mutations are needed to fully leverage the possibilities of genome sequencing in diagnosis.
Accurate prediction tools for mortality may guide clinical decision-making , particularly among elderly persons with CKD.
Accurate segmentation of the hippocampus from infant MR brain images is a critical step for investigating early brain development.
Accurate working memory performance in both age groups was associated with high fronto-visual functional connectivity ( fC ) .
AC-drug exposure was assessed using the Anticholinergic Cognitive Burden Scale ( ACBS ) .
ACE I / D polymorphisms were detected by polymerase chain reaction using specific primer.
ACEIs and beta-blockers were frequently underprescribed and were associated with heart failure admissions.
ACEIs , diuretics and NSAID were the most common therapeutic groups.
A cell-based prion infection assay did not provide supportive evidence for a role for PARK2 in prion disease susceptibility.
A cell proliferation and colony formation assays revealed significantly less growth of RECQL1 ( - ) cells compared to RECQL1 ( + ) cells.
A cell strain obtained from a pool of @number@ human subjects was treated with cytochalasin B in vitro for @number@ hours.
A central concept is personal health system for the patient / citizen and three main application areas are identified.
A central controller unit allows using the stimulator as a stand-alone device.
A central issue in olfaction concerns the characterization of loss of olfactory function : partial ( hyposmia ) or total ( anosmia ) .
A cervicovaginal lavage ( CVL ) with sterile saline and a peripheral blood sample were obtained.
Acetazolamide ( ACM ) treatment partially reversed the growth deficit of kl / kl mice.
Acetohexamide exerted this protective function by antagonizing expression of the DNA glycosylase , MUTYH.
Acetoin , a beer fermentation byproduct , also emerged as possible precursor in beer when combined with serine.
Acetylation enhanced the GdnHCl-induced unfolding and slowed the subsequent refolding of γD-crystallin.
Acetylcarnitine supplementation induces neuroprotective , neurotrophic and analgesic effects in the peripheral nervous system.
Acetyl coenzyme A ( CoA ) is a key metabolite that links metabolism with signaling , chromatin structure , and transcription.
Acetyl-L-carnitine ( ALC ) is a molecule derived from acetylation of carnitine in the mitochondria.
ACF1 interacts directly with KU70 and is required for the accumulation of KU proteins at DSBs.
ACFI also captures health conditions that are considered to affect the cost of people's care , such as dementia.
A ' challenge and response ' framework is suggested for future research on active ageing.
A challenge in the field is to determine the molecular mechanisms involved in the organization of genome function.
Ach- and SNP-induced vasodilatation in elderly arterioles was significantly decreased compared with that of gastric submucosal arterioles from young patients.
A change in the lipoprotein profile is a metabolic hallmark of aging and has been the target for modern medical developments.
A change in what is considered normative aging and developmental tasks for certain age groups calls for further research in those age groups.
A change-point in our model reflects the transition from the cognitive decline due to normal aging to the accelerated decline due to disease progression.
A characteristic example of MD is sporadic thoracic aortic aneurysm ( S-TAA ) , whose patho-physiological mechanisms remain unclear.
ACHD patients over @number@ showed a significantly greater percentage of probable anxiety cases than those in their @number@ s and the reference group.
AChE activity in different brain regions of rePON1 pretreated animals exposed to sarin or soman were also significantly higher than respective controls.
AChE-deficient also had decreased PS1.
AChEIs have opposing effects to DAPs and , consequently , concomitant use of DAPs and AChEIs may further impair cognition among patients with dementia.
AChE knockdown with siRNA also decreased PS1 levels , while AChE overexpression exerted opposing effect.
A chemical sunscreen was applied thirty minutes into the incubation and subsequently patients sat outside in the shade for @number@ hours.
ACh has an excitatory effect on SCN cells ( at least in vivo ) , and functions in close interaction with other neurotransmitters.
Achievement of goals during the hospital stay was significantly correlated with the questionnaire score.
Achievement ranged from @percent@ for cerebrovascular disease to @percent@ for osteoarthritis.
Achievements of nutriceutical interventions aimed at restoring normal SSL composition and homeostasis are discussed , as feasible therapeutic goals and major means of photo-protection.
Achieving a long lasting and aesthetically pleasing forehead is possible only with surgical techniques when aging is obvious.
Achieving FTSS in less than @number@ seconds made unlikely the existence of a moderate cognitive impairment.
Achieving the therapeutic goal regarding systolic hypertension proves difficult.
Achieving what patients perceive as an integrated and effective system will require time and commitment.
Achilles tendinopathies display focal tissue thickening with pain and ultrasonography changes.
Achilles tendinopathy is a highly prevalent sports injury.
Achilles tendon injuries predominantly occur in the tendon region between the Achilles-soleus myotendinous junction and Achilles-calcaneus osteotendinous junction i.e. in the free Achilles tendon.
A Chinese version of the Standardized Nordic Musculoskeletal Questionnaire ( NMQ ) were also administered to collect the information of perceived neck / shoulder symptoms.
A chi-square-based Q test and sensitivity analyses were performed to test between-study heterogeneity and the contributions of single studies to the final results , respectively.
A chi-square test of independence was performed to examine the difference in age , gender and previous working experience between the two groups.
Achivement and Hedonism values were associated with more alcohol consumption , whereas Universialism , Tradition , and Conformity were related to lower alcohol consumption.
A chronic disease surveillance network fills an important gap in current public health surveillance systems.
A chronic vascular inflammatory state plays an important role in the pathophysiology of thalassaemia.
A chronologic sequence viruria-viremia-HC was identified.
A circumpapillary and radial OCT scan centered on the optic nerve head ( ONH ) was used for data analysis.
Acknowledging substantial and sometimes surprising effects of housing conditions , chronobiology , and intersex differences will further augment the translational value of animal models.
A clarification of the level of 25 ( OH ) D concentrations that is most beneficial for predicting better cognitive performance in mid-life is required.
A clarification of the reasons for such discrepancy may provide clinically significant information.
A \ "classically \ " activated M1 phenotype is known to eradicate toxicity.
A class of older , senescent individuals can help shield the juveniles from predation , stabilizing demographics and avoiding extinction.
A clear difference in the association between depressive symptoms and socioeconomic factors by gender was observed.
A clear dose-response association between the quintiles of self-reported supplementary calcium intake and AMD was not established.
A clearer understanding of UVR is crucial in the prevention of skin cancer.
A clear gender difference was newly discovered , as depression played a stronger role in women.
A clear increase in the width of the neonatal line was thus observed along with a decrease in the child's age at death.
A clear North-South gradient was found for health expenditures , and partially for YLDs , costs and diseases ' prevalence.
A clear understanding and working knowledge of the functional anatomy and pathophysiology will enable appropriate diagnosis and treatment of these disorders.
A clear understanding is lacking.
A clear understanding of the HS concept and its measurement in the area of dementia might improve the effectiveness of the process.
A clinical and neuropsychological follow-up was performed in a subgroup of participants with MCI-AD , MCI-O , and AD dementia.
A clinical assessment and a structured interview were carried out.
A clinical diagnosis and etiology of HF can often be established during history and physical examination.
A clinical evaluation and a standardized assessment were carried out.
A clinically meaningful change was defined as @number@ points.
A clinically meaningful treatment difference of @number@ in pain score between oxycodone DETERx and placebo was observed.
A clinical trial of PREPARE is currently underway.
A clinical trial of tocotrienol supplementation for @number@ months suggested a beneficial effect of intake on DNA damage rates , but only in elderly people.
ACL is a nationally representative sample of adults @number@ years of age or older who lived in the United States.
A close agreement was achieved between the calculated and measured data with a maximum difference of only @percent@.
A close association between complex plaque and renal dysfunction raises the possibility that complex plaque in the DTA is a potential cause of renal dysfunction.
A close-up front and 45-degree lateral photographs of both sides must be taken.
A cloud-based system enables access to interested researchers with blinded data available contingent upon completion of a data usage agreement and administrative approval.
ACLR should be considered in active older patients with subjective functional instability.
A cluster analysis of their discourse macrolinguistic features was conducted.
A cluster analysis was conducted to identify profiles with similar HrF.
A cluster analysis was performed on echocardiographic variables , and the association between clusters and clinical profiles and outcomes was assessed.
A clustering procedure was then used to distinguish regions based on patterns of scaling of regional WMSA to global WMSA.
A cluster score , using the MetS components as continuous variables , is more reliable in predicting young adult risk from late childhood.
ACM tripled the life span of kl / kl mice.
Acne is a disorder of the pilosebaceous unit , common among adolescents , which may be extended to adulthood.
ACO2 activity was evaluated in a subsample before and after in vitro exposure to free radicals.
A co-contraction index was computed reflecting the magnitude of moment produced by fingers acting against the required direction of the total moment.
A codification of therapeutic indications is proposed.
A cognitive change point occurred between @number@ and @number@ years before the clinical diagnosis of AD dementia.
A cognitive enhancing effect by MR stimulation warrants future studies.
A cognitive factor measuring speeded selective attention and switching was uniquely associated with the most errors types.
A cognitive load effect was also observed in the cognitive outcomes , with unexpected results.
A Cognitive ToM deficit was found in @percent@ of patients , with @percent@ showing an isolated Cognitive ToM deficit.
A cohort of men and women aged @number@ @number@ and @number@ years were recruited from the Västerbotten Intervention Programme.
A cohort of @number@ diabetic men aged ≥ @number@ years recruited in 1995-1998 was followed prospectively.
A cohort of @number@ ( @number@ male , @number@ female ) participants completed two HR-pQCT scans with @number@ years between assessments.
A cohort of @number@ patients , @number@ treated and @number@ untreated hypogonadal men , and @number@ eugonadal men were included.
A Cohort Profile article was published in @number@
A collective memory is a representation of the past that is shared by members of a group.
A combination approach including neurotoxin and volume restoration demonstrates superior results in select settings.
A combination of intrinsic and extrinsic factors appears to contribute to these disruptions.
A combination of methods will be the most preferred tool to find out any risk or situation of dehydration at any age range.
A combination of MMG and knee extension performance variables estimated types I , IIa , and IIx MHCs with approximately @percent@ accuracy.
A combination of molecular , genetic , proteomic , and biochemical approaches has revealed the complex and coordinated action of telomerase and telomere-associated proteins.
A combination of radiation treatment with androgen ablation provides good control of the disease while preserving renal function.
A combination of symptoms predicts LOH better than any single symptom.
A combination of the Braak and CERAD staging scales was recommended by the National Institute on Aging and Reagan Institute ( NIA-RI ) .
A combined approach captures the largest number and broadest range of delirium cases.
A combined mFI and ASA variable can be used to predict 30-day mortality for RARP patients better than mFI or ASA alone.
A commentary is offered on the chapters that comprise the section on Theoretical Foundations , emphasizing novel contributions of each.
A commentary of the article discussing the possible reimagining of long-term care ( LTC ) is provided.
A commercially available retinol cream delivered similar effects to SS.
A commitment was made about updating it if new scientific evidence became available.
A common approach is integrating expression information with gene association networks in order to find groups of connected genes that are activated or repressed.
A common aspect of SST and QC is the longitudinal nature of the data.
A common but significant change associated with aging is a profound disruption to the daily sleep-wake cycle.
A common characteristic between these disorders is the accumulation of protein deposits composed by aberrant protein aggregates.
A common characteristic of aging is loss of skeletal muscle ( sarcopenia ) , which can lead to falls and fractures.
A common characteristic of these membrane domains is their association with cholesterol.
A common error in their management is that injury from the fall is treated , without finding its cause.
A common example is the transformation of a hand movement in the motion of a cursor on a computer monitor.
A common feature of many neurodegenerative diseases is the deposition of β-sheet-rich amyloid aggregates formed by proteins specific to these diseases.
A common feature of these conditions is that they are generally associated with accelerated aging.
A common feature of these diseases is altered proteostasis.
A commonly used model for biological aging was proposed by Penna.
A common misconception is that such experience-dependent plasticity ( e.g. , associative learning ) is synonymous with synaptic plasticity.
A common side-effect of calcitriol therapy was hypercalcemia and hypercalciuria , but the degree of hypercalcemia was mild.
A common symptom of insufficient melatonin signaling is sleep disturbances.
A community advisory board was convened to guide establishment of the biobank and identify key deliverables from the research project and for the community.
A community-based implementation of TCDS has the potential to improve health outcomes for a diverse , Spanish-speaking , older adult population.
A community-based sample of @number@ cognitively intact , healthy adults were recruited from the Dallas-Fort Worth metroplex.
A community comparison group ( N = @number@ ) was recruited using randomly selected block groups.
A community-wide sample of @number@ men and women aged @number@ years or older participated in the survey.
A comparable alternative task may expand options for examining acute stress in a controlled laboratory setting.
A comparative analysis was performed to explore the etiology and comorbidities of CHF and in-hospital mortality in patients with CHF.
A comparison between @number@ ( n = @number@ ) and @number@ ( n = @number@ ) was performed.
A comparison of both lacunes and DWMH with respect to the TMT-B results showed no significant correlation.
A comparison of intervention effectiveness was not possible because of their heterogeneity , which precluded a meta-analysis.
A comparison of reported motivations to efficacy reported in the literature of single BS was conducted.
A comparison of results between studies would appear to be impossible.
A comparison of the long-term mortality between the two cohorts through follow-up until @number@ was performed.
A comparison of the microvessel density between zones according to age was performed by an analysis of variance.
A comparison was made to ages 18-64 years , and comparing \ "as needed \ " vs standing orders.
A compendium that summarizes previous findings of cohort studies evaluating vitamin intake and mortality is provided.
A compensatory step was necessary to regain stability.
A complementary purpose was to test the mediating role of depressive symptoms and physical activity in the relation between subjective age and memory changes.
A complete blood count showed leukocytosis with neutrophilia and eosinophilia , and the chest X-ray showed consolidation of the left upper lung at POD @number@
A complete evaluation was performed , including a systematic evaluation of the UA prior to conducting PSG.
A complete listing of ADNI investigators can be found at : @url@ to apply / ADNI Acknowledgement List.pdf.
A complex interaction of various risk factors including lifestyle , associated conditions , and identifiable secondary causes can lead to uncontrolled hypertension.
A complex interplay between multiple biological effects shapes the aging process.
A complex interplay of genetic , environmental , hormonal , and behavioral factors affect skeletal development , several of which are associated with childhood fractures.
A complex mathematic algorithm processed the results obtained for each patient and , on this basis , calculated the biological age of the patient's skin.
A complex neurally mediated diagnosis is frequent in older people.
A complicating factor in evaluating a new approach is that it may not be automatically adopted by clinicians.
A component of this drift is tissue-specific , allowing remarkably accurate age-predictive models to be constructed.
A composite cognitive score was also computed.
A composite cognitive score was derived based on nine standardized cognitive test scores.
A composite domain score was generated for each of the four domains.
A composite global cognition was constructed using all tests.
A composite healthy aging outcome was defined as being free of @number@ chronic diseases and major cognitive or physical impairment.
A composite index of cardiovascular risk , the Framingham General Cardiovascular Risk Profile , showed no associations with task performance or task-related DMN suppression.
A composite measure of pulmonary function was based on spirometric measures of forced vital capacity , forced expiratory volume , and peak expiratory flow.
A composite measure of WM scores was used as an index of WM capacity.
A composite mobility measure , which summarized gait and balance measures , was used to examine the annual rate of mobility change.
A composite score of physical function was created based on the timed up-and-go , alternate step , sit-to-stand , and balance tests.
A composite Z-score was created based on the individual scores for each Senior Fitness Test battery item.
A comprehensive and systematic approach to restoration of the lower eyelid is highlighted with specific postoperative results.
A comprehensive care plan was developed including specific recommendations for implementing change.
A comprehensive compliance management with included measurements of muscle activity and stimulation intensity enables a scientific use of the stimulator in clinical trials.
A comprehensive echocardiographic examination was obtained from all subjects following predefined protocols.
A comprehensive evaluation of the risks associated with surgery and suppression of the immune system in this often comorbid population becomes the focus.
A comprehensive geriatric assessment was complemented with assessment for the frailty phenotype as described by Fried et al for all patients in the study group.
A comprehensive health assessment was made at enrollment and then repeated regularly on an ongoing basis.
A comprehensive literature search identified eight RCTs that met inclusion criteria , and produced a total sample of @number@ participants.
A comprehensive literature search was conducted using Medline , CINAHL , Scopus , PubMed and the Cochrane Library.
A comprehensive literature search was performed on PubMed , EMbase and the Cochrane Library from inception to @date@ .
A comprehensive literature search yielded @number@ studies that met the inclusion criteria for the present meta-analysis.
A comprehensive neurocognitive assessment was performed.
A comprehensive neuropsychological battery was administered and cognitive function was summarized as composite and domain-specific Z-scores.
A comprehensive ophthalmic exam was performed with mea surement of both the presenting ( PVA ) and best-corrected visual acuity.
A comprehensive ophthalmological examination including refraction , tonometry , and Scheimpflug imaging of the anterior cornea ( Pachycam ) was performed.
A comprehensive picture of the management of hypertension in the increasing elderly population in Singapore is lacking.
A comprehensive research agenda should ensure the future study of a full range of patient-centered outcomes.
A comprehensive review of the literature was completed using MEDLINE and PubMed Library databases.
A comprehensive search of MEDLINE , EMBASE , UpToDate , and the Cochrane Library was conducted.
A comprehensive search was conducted to identify studies of FOXO3A gene polymorphisms and longevity.
A comprehensive search yielded @number@ studies ; @number@ studies with @number@ participants ( @number@ ± @number@ yr , @percent@ female ) were included.
A comprehensive , systematic database search for manuscripts was performed.
A comprehensive understanding of cadherin-based morphogenesis must then define the molecular and cellular mechanisms that support these distinct cadherin biologies.
A comprehensive understanding of the biogenesis of this phenomenon and mechanistic changes from oxidative pathways may provide novel information on completing the sundowning puzzle.
A compromised muscle function due to aging , sarcopenia and reduced level of physical activity can lead to metabolic complications and chronic diseases.
A computer-generated permuted block randomisation sequence , with randomly selected block sizes , will be used for allocation.
A computerized Stroop test was used ( including both congruent and incongruent Stroop tasks ) which calculates a response time automatically.
A conceptual model has emerged to explain this syndrome of diseases where HIV-mediated destruction of gut mucosa leads to local and systemic inflammation.
A concerning number of submissions discuss having had or having considered an unattended birth at home due to these barriers.
A concurrent visuo-cognitive task was performed in @percent@ of PV trials but had little impact on reach-to-grasp timing or accuracy.
A confidence interval of @percent@ and level of significance of @percent@ were considered for all the tests performed.
A confirmatory factor analysis ( CFA ) was used to confirm the four factor structure of the IPAFin.
A confirmatory factor analysis indicated poor fit.
A confirmatory factor analysis was run to confirm the factor structure of the shortened-form of the revised Drinking Motives Questionnaire.
A confirmatory sample with @number@ years follow-up was also included.
A connection between dementias and blood-brain barrier ( BBB ) dysfunction has been suggested , but previous studies have yielded conflicting results.
A consensus definition will facilitate communication and cross-study comparison and may have regulatory applications in drug development programs.
A consensus panel diagnosed dementia using standard research criteria.
A consensus panel in the ADAMS assigned cognitive category.
A consequence of this protection is cellular senescence and ageing.
A conservative treatment was adopted in @number@ patients while an invasive approach was adopted in @number@ patients ( endovascular approach in @number@ ) .
A conserved factor that orchestrates distinct substrate-processing co-regulators in diverse species is the ubiquitin-selective chaperone CDC-48 ( also known as p97 ) .
A considerable burden of illness has been shown to be associated with moderate to severe premenstrual disorders.
A considerable decrease , by @percent@ , was determined in the 7th decennium.
A considerable development of both pathological states atypical of radiation damages and diseases , which may be considered as radiation-induced ones , was determined.
A considerable proportion ( @percent@ ) of the hospitalized patients remained undiagnosed.
A consistency category was assigned based on the similarity of themes in each of @number@ pairs of definitions.
A consistent spatial pattern of WMSA accumulation was observed with increasing quartile.
A constant comparison approach was applied during data analysis.
A constructivist grounded theory methodology was used.
A contact hour certificate will be awarded once you register , pay the registration fee , and complete the evaluation form online at @url@
A contact hour is a unit of measurement that denotes @number@ minutes of an organized learning activity.
A content analysis approach was used.
A content analysis approach was used for the verbatim transcription.
A content analysis was conducted using ATLAS.ti software to identify events and salient themes.
A continued change in miRNA expression persisted during disease progression indicating the potential use of these particular miRNAs as longitudinal biomarkers in ALS.
A continued effort to strengthen the eye health system is necessary to support the growing unmet need in an aging and growing population.
A continuous decrease of episodic quality of memory ( memory specificity , narrative quality ) was confirmed.
A contrastive accent on a particular pair improved later recognition memory equally for young and older adults.
A control group consisted of @number@ healthy volunteers matched to the study group patients for age and gender.
A control group consisted of @number@ women aged 18-45 years with a BMI of less than @number@ kg / m2.
A control group ( n = 24 ) received placebo pills on each occasion.
A control group of N = 19 participants received gamma ( 40-43Hz ) or sham EEG-IC.
A control group of @number@ healthy subjects provided normal data.
A control group of twenty-two women , with similar ages to the first group , applied the cream alone.
A control group was established in which animals were fed a non-protein-modified AIN-93 diet.
A control group was used to compare the high-frequency audiometry results.
A control population , frequency matched for age , sex , and smoking status , will be recruited from the general population.
A control population of healthy age- and sex-matched controls was included with a matching ratio of 1 : 2.
A controversial hypothesis is that genetic factors influence vulnerability to depression following stress.
A controversy exists as to whether de novo-generated neuronal tetraploidy ( dnNT ) occurs in Alzheimer's disease.
A convenience sample and a prospective cohort design were used.
A convenience sample of @number@ participants from a community care station was recruited.
A convenience sample of @number@ rural community-dwelling older adults , @number@ years and above , participated.
A convenience sample of @number@ university members who participated in the program was used.
A convenience sample of patients , aged @number@ years and older , undergoing unplanned overnight medical admissions was screened.
A coordinated transdisciplinary approach best tackles the complexities encountered in these patients.
A coordinate system analysis based on stable landmarks is used.
A coordinator should setup a process for the systematic investigations for future fracture risk in all elderly patients with a recent fracture.
A core category-motivating oneself to resist being controlled by chronic pain-emerged from the analysis of experiences among participants with chronic pain.
A corollary of this complexity reduction is an attenuation of Bayesian updating or sensory learning.
A corollary of this hypothesis is that interventions aiming to decrease inflammaging should protect against cancer , as well as most / all age-related diseases.
A correlational approach was used to assess the association between variables.
A correlation analysis between biomechanical and clinical variables was also performed.
A correlation analysis was performed between the measured variables and a low-back pain disability index.
A correlation between CDP and consumption of orange- and green-coloured fruits and vegetables , vegetable oils and soup was observed.
A correlation between these two measures would suggest that they may be influenced by the same underlying age-related biological process.
A correlation was found between choroidal thickness , age , refractive error , and axial length at all locations.
A correlation was found between choroidal thickness and all parameters studied.
A correlation was found between social support and social participation of older adults.
A correlation was observed between VEGF and scores on SGDS-K , but no correlation was detected between VEGF and MMSE-KC scores.
A correlation with Mini Mental State Examination ( MMSE ) , Lexis , and memory tests revealed the dSWM impact on cognition.
ACOS has been found to be associated with impaired physical performance , functional ability , and health-related quality of life.
A cost-effective and unobtrusive way to remotely monitor changing sleep patterns over time would enable improved management of this important health problem.
A cost that included unimanual noise and strength accounted for both direction- and handedness-dependent choices that young people made.
ACOT7 mRNA decay was triggered by the microRNA miR-9 in a WIG1-dependent manner via classic recruitment of Argonaute @number@ ( AGO2 ) .
Acoustic and visual cues are frequently used in gait rehabilitation.
Acoustic detail ( temporal fine structure ) and predictiveness ( the degree to which the first digit predicted the second ) varied orthogonally.
Acoustic radiation force impulse ( ARFI ) is an image-guided ultrasound elastography method that allows quantification of liver stiffness by measurement of shear wave velocity.
Acoustic rhinometry confirmed that nasal cavities are becoming larger across the lifespan.
A Cox proportional hazard model was used to determine adjusted hazard ratios of mortality with @percent@ confidence intervals ( @percent@ CI ) for handgrip strength.
A Cox proportional-hazard regression model was performed in non-survivors for clinical factors from the CGA , along with c reactive protein ( CRP ) .
A Cox-proportional hazard regression model with adjustment for multiple confounding factors was used for the association analyses.
A Cox regression analysis , the c-statistic , a risk reclassification analysis , and bootstrapping techniques were used to analyze the data.
A Cox regression model was used to estimate the interaction between SRH and SES for @number@ individuals without missing data.
AC progression did not differ between treatment groups when analyzed by baseline estimated glomerular filtration rate or by baseline AC scores.
AC progression was defined as change in AC score > 0.
Acquired aplastic anaemia ( AA ) is an immune-mediated bone marrow failure disorder inextricably linked to clonal haematopoiesis.
Acquired data on the aesthetic result were statistically evaluated using Student t-test.
Acquired memory is initially dependent on the hippocampus ( HPC ) for permanent memory formation.
Acquisition of a senescence-associated secretory phenotype ( SASP ) in dermal fibroblasts has been postulated to promote skin cancer progression in elderly individuals.
Acquisition of new motor skills requires the interplay between different cortical motor areas.
Acquisition of superficial ( \ "chunk-based \ " ) and structural ( \ "rule-based \ " ) features of the grammar were analyzed separately.
Acquisition of the endosymbiotic ancestor of mitochondria was a critical event in eukaryote evolution.
Acral lentiginous melanoma ( ALM ) is the most common type of cutaneous melanoma in Asian populations.
A CR-composite , combining years of education and word-reading ability , significantly predicted apathy ( t = @number@ p = @number@ ) .
A ' critical computational linguistics ' method was used involving novel software-driven quantitative mapping and traditional critical discourse analysis.
A critical discussion of new techniques for assessing vascular stiffness is also presented.
A critical issue in managing older people with pain is the need for judicious choice of analgesics based on a comprehensive medical and medication history.
A critical issue in molecule selection is accurate calculation of the p-value of the rank product statistic to adequately address multiple testing.
A critical key to successful medical intervention is getting the dose right.
A critically shortened telomere activates the genetic program of cell senescence and / or apoptosis.
A critical pathway in this regard is the Nrf2 ( nuclear factor erythroid 2-related factor @number@ ) - antioxidant response element ( ARE ) pathway.
A critical question is whether the policy lacuna reflects a dearth of research evidence or a faulty translation of existing knowledge.
A critical ratio was used to establish the shift from a 1-handed to an exclusive 2-handed reach.
Acrodermatitis enteropathica is an autosomal recessive disorder characterized by scaly eczematous dermatosis accompanied by alopecia and diarrhea.
Acrolein , furan , acrylonitrile , and @number@ , 3-butadiene were considered to be the most harmful VOCs.
Acromial secondary ossification centers began forming at age @number@ and clavicular ones , while uncommon , began forming at age @number@
Across age groups , neuropsychological markers further linked early CNV magnitude directly to individual attentional capacity.
Across all groups , higher modularity and small-worldness strongly correlated with reduced distractibility on an implicit priming task.
Across all @number@ groups , fall rates peaked in middle age ( 45-64y ) and among people with moderate mobility limitations.
Across all older participants , rate of EMG rise was positively associated with acceleration , power , and the SPPB score.
Across all participants , greater attentional bias toward negative words was correlated with decreased PFC recruitment.
Across all participants , increased pupil diameter differentiated subsequently remembered from forgotten words , and neural activity covaried with pupil diameter in cuneus and precuneus.
Across all sets of criteria , the authors found significant positive associations between neuropsychological diagnoses and Clinical Dementia Rating score categories.
Across all subjects , both visual acuity and contrast sensitivity contributed significantly to the variances in RTs and accuracy.
Across both experiments , the response latency results were overall consistent with an influence of desirable difficulty on retention.
Across both studies , @number@ of @number@ participants increased their steps according to experimenter-arranged criteria.
Across both studies , there was no evidence of age differences in the preferred timing of shocks.
A cross-cultural comparison was conducted , and possible reasons for the discrepancy between subjective and chronological ages were examined.
Across cultures , older adults reported lower negative affect than did young adults.
Across decision contexts , those individuals who focused more on positive information than negative information reported better postdecisional mood and greater decision satisfaction.
Across different experimental conditions and stimulus sets , smiling faces were consistently perceived as older compared to neutral face photos of the same persons.
Across four RCTs , dance therapy reduced falls versus usual care in only one study.
Across groups , duration of iSP from TMS was inversely correlated with BOLD activity in iM1 during unimanual movement.
Across HbA1c levels , rates of hypoglycemia were @date@ @percent@.
Across health states , ratings over time or within elder-proxy dyads were no more than one category apart in over @percent@ of cases.
A cross-lagged model combined with survival analysis was used to assess the relationships between loneliness , behavioral and health outcomes , and risk of mortality.
A cross-lagged panel design was applied with structural equation modeling.
Across lifespan , we observed an increase of the RNA-editing level with advanced age in both brain regions of all three primate species.
Across @number@ experiments , older adults made more false alarms to near re-pairings than to far re-pairings.
Across @number@ years , changes in ABI were not associated with changes in cognitive function.
Across numerous model systems , aging skeletal muscle demonstrates an impaired regenerative response when exposed to the same stimulus as young muscle.
Across participants , steps increased @percent@ , and @percent@ of goals were met.
Across participants , steps increased @percent@ from screening to the end of the intervention , and @percent@ of step goals were met.
Across patients , the whole-brain atrophy rate was @percent@ per year , with accelerated atrophy in the ipsilesional hemisphere.
A crossroads has been reached on research into docosahexaenoic acid ( DHA ) and Alzheimer's disease ( AD ) .
A cross-sectional analysis of results from the first wave showed higher performance in females than males , with a steeper age-related decline in males.
A cross-sectional analysis was conducted using data from Colaus / PsyColaus , a longitudinal population-based study among Lausanne residents.
A cross-sectional assessment was performed by measuring serum AMH levels and filling out a questionnaire.
A cross-sectional convenience sample of @number@ clinicians were identified and administered a questionnaire.
A cross-sectional study of the Queensland population was conducted via telephone interviews ( n = @number@ ) .
A cross-sectional study using a slit-lamp ophthalmoscope for examination was carried out from @date@ to @date@ .
A cross-sectional study was conducted in a county of Henan Province , China , including high fluoride exposure from drinking water villages and control villages.
A cross-sectional study was conducted to assess the validity of the MPI relative to standard neuropsychological measures.
A cross-sectional study was designed , and @number@ fishermen working aboard SM fishing vessels were interviewed to collect information about their safety and health.
A cross-sectional study was designed including @number@ women able to independently perform basic activities of daily life.
A cross-sectional study was designed to assess age-related differences in activity of trunk extensors during forward bending and backward return.
A cross-sectional study was made with @number@ healthy elderly subjects from Florianópolis , Santa Catarina State , Brazil.
A cross-sectional study was performed with @number@ professionals ( gynaecologists , physicians and nurses ) from four public centres in Spain.
A cross sectional survey , consisting of @number@ questions including the 26-item WHOQOL-BREF and the 24-item WHOQOL-OLD was administered to @number@ participants.
A cross-sectional survey of low-income older Korean immigrants who use ADHC programs was conducted.
A cross-sectional survey targeted @number@ people.
Across species structural and functional hemispheric asymmetry is a fundamental feature of the brain.
Across stages of AD , we expected individual spatial correspondence of Aβ and iFC to reveal both Aβ accumulation and its detrimental effects on iFC.
Across subject groups , visual motion processing showed a similar pattern of increasing thresholds , with the greatest impact on radial pattern motion perception.
Across the board , these precursor populations were phenotypically naive and occurred with hierarchical frequencies clustered by Ag specificity.
Across the demographic transition , declining mortality followed by declining fertility produces decades of rising support ratios as child dependency falls.
Across the life span from @number@ to @number@ years of age , mean IL-6 levels were strikingly lower in Japanese individuals.
Across the lifespan , people with autism experience a much lower quality of life compared to people without autism.
Across the @number@ studies , @number@ of the @number@ analyzed PLFAs had unadjusted correlations > @number@ and @number@ had adjusted correlations > @number@
Across the @number@ years , these hospitalizations increased @percent@ for women , @percent@ for men ( both P < @number@ ) .
Across the SABE population , between @percent@ ( Mexico City ) to @percent@ ( Santiago ) reported missing teeth , with an average of @percent@.
Across the sample , the phenotypic correlation between LTL and FEV1 was modest ( r = @number@ p = @number@ ) .
Across the solar radiation spectrum , UV light is the main cause behind skin problems.
Across the subcortical areas an increase of [ Formula : see text ] values is observed , most likely indicating a loss of myelin.
Across trials that varied in EVs , participants decided to accept or decline the offered stakes to maximize total accumulated points.
A cross-validation of these findings will have implications for possible treatment interventions , especially for males with high TC.
A crucial area to consider is the measurement of medication adherence , both as an independent factor and as a confounder.
A crucial limitation , however , is that this study confines itself to elderly population.
A crucial question in this context is why only certain proteins appear to aggregate readily in vivo , whereas others do not.
A crucial task in social interaction involves understanding subjective mental states.
AC scores were assessed using a semiquantitative method from lateral spine X-rays.
ACS hospitalizations constitute @percent@ of all hospitalizations for the younger residents and @percent@ of all hospitalizations for the older residents.
ACSL3 is expressed in both androgen-sensitive and castration-resistant prostate cancer ( CRPC ) .
Acsl4-mediated conversion of AA to AA-CoA showed substrate inhibition and had a 10-times higher catalytic efficiency than did conversion of DHA to DHA-CoA.
ACS patients had significantly higher levels of NK cells and CD8 + T-cells ( p < @number@ ) .
ACSRP can be activated by factors ranging from exercise and dietary energy restriction , to drugs and phytochemicals.
ACS was associated with high differentiation in CD4 + and CD8 + T-lymphocytes.
A CTAB nanobubble diluent ( 1 / 150 ) increased the LDH release 80-fold.
Act-Belong-Commit indicators are shown to be protective against mental disorders and cognitive impairment among older Irish adults.
ACTH and cortisol concentrations were measured every @number@ min during the feedback-clamp phase and thereafter ( recovery or escape phase ) .
ACTH was measured every @number@ min during the last @number@ h of the infusions.
Actigraph accelerometer is widely used to objectively assess PA , and the raw data is given in counts per unit time.
Actigraphic monitoring is integrated with the facilities ' social alarm system.
Actigraphy data showed normal sleep efficiency and timing of the nighttime sleep period for both patients and their caregivers.
Actigraphy may be a useful objective tool for screening MPS-severe.
Actigraphy was recorded over five to @number@ days.
Actigraphy was used to monitor sleep.
Actinic elastosis was identified by the lysozyme coating of elastic fibres.
Actinic keratosis and non-melanoma skin cancers were early detected and managed.
Actin is required for stress fiber formation ; thus , the interaction of actin with Trx-1 might interfere with this process.
Actinomyces israelii is the organism most commonly found in human disease.
Actinomycosis in the central nervous system may produce brain abscess , meningitis , subdural empyema , actinomycetoma , and spinal and cranial epidural abscess.
Actinomycosis is a chronic suppurative bacterial infection caused by Actinomyces species.
Actinomycosis usually manifests with abscess formation , dense fibrosis , and draining sinuses.
Actin reorganization , a prerequisite for cell migration , was determined using Atto @number@ phalloidin in neutrophils by flow cytometry and fluorescence microscopy.
Action cues prompting vaccination and vaccine access further affected the vaccine uptake of participants with vaccine preferences.
Action- ( e.g. attentional control ) and emotion ( e.g. biofeedback training ) -centred applied sport psychology implications are advanced.
Action integration is the process through which actions performed on a stimulus and perceptual aspects of the stimulus become bound as a unitary object.
Action learning and motor control accuracy are uniquely associated with EF for older adults only , and only if the sequences are complex.
Action Measures did not change significantly.
Actions were registered in the CDSS.
Activated cells in the central nervous system ( CNS ) produce pro-inflammatory mediators that lead to the recruitment of myeloid or lymphocytic cells.
Activated LATS1 / 2 in turn phosphorylate and inhibit Yes-associated protein ( YAP ) .
Activated NBs , having a core and a shell , were observed by electron microscopy in control but not in NIHID cases.
Activated neutrophils play a significant role in the pathogenesis of many inflammatory diseases.
Activating AMPK or inactivating calcineurin slows ageing in Caenorhabditis elegans and both have been implicated as therapeutic targets for age-related pathology in mammals.
Activating mutations of the @date@ receptor have been identified.
Activation by a wide variety of stimuli leads to secretion of this cytoplasmic protein.
Activation differences were noted with ankle movements only.
Activation-induced cytidine deaminase ( AID ) is a key enzyme for antibody-mediated immune responses.
Activation in paralimbic posterior cingulate and inferior temporal brain regions of visual-spatial saliency processing was progressively reduced in activation with increasing development.
Activation in the ventral striatum increased with age during reward receipt as compared to receiving neutral outcome.
Activation of AMPK / mTOR signaling protected PTCs from high glucose-induced EMT and cellular senescence.
Activation of astrocytes produces inflammatory cytokines and the enzyme cyclooxygenase-2 , enhancing the production of Aβ.
Activation of autophagy during ischemia is essential for cell survival and maintenance of cardiac function.
Activation of autophagy during reperfusion could be either protective or detrimental , depending on the experimental model.
Activation of autophagy is generally considered to be cardioprotective , whereas excessive autophagy can lead to cell death and cardiac atrophy.
Activation of CFTR by genistein partially rescued the decreased forward motility in sperm from old men.
Activation of endogenous p53 enhances Arf repression , and reintroduction of p53 back into p53 null MEFs restores Arf repression.
Activation of intravascular fibrinolysis is one of the principle effects of cardiopulmonary bypass that causes poor postoperative hemostasis.
Activation of NFκB levels , one of the downstream events induced by UVA irradiation and MMP-1 induction , were also prevented by Lycogen™ administration.
Activation of NMDA receptors allows a calcium flux into dendritic spines that serves as the proximal trigger for LTP.
Activation of PPAR-γ improves endothelial dysfunction and inflammation.
Activation of temporo-parietal regions was greater in elderly participants irrespective of spatial frequencies.
Activation of TERT is considered a crucial step in tumorigenesis , and therefore it is a potential therapeutic target against cancer.
Activation of the G protein-coupled estrogen receptor ( GPER ) can mediate multiple salutary effects on the cardiovascular system.
Activation of the latter influences macrophage cholesterol efflux that is a key process in the prevention of atherosclerotic cardiovascular disease.
Activation of the mammalian target of rapamycin ( mTOR ) has been implicated in anticancer drug resistance , type @number@ diabetes , and aging.
Activation of the NF-κB pathway was confirmed in EBV-infected cell lines using an electrophoretic mobility shift assay.
Activation of this cascade is markedly inhibited in the hearts of wild-type mice following induction of cardiomyopathy.
Activation of this pathway has been proposed to underlie lifespan extension from knockdown or mutation of several nuclear encoded mitochondrial genes in Caenorhabditis elegans.
Activation of vitamin D depends on the endocrine function of both , liver and kidney.
Activation patterns of 13- , 17- and 21-year-old males were compared during the decision phase of a challenging and complex gambling paradigm.
Activation related to Reward Anticipation increased with age , while activation related to Reward Outcome decreased in various regions of the reward network.
Activation shifted from a rostral / anterior to a more dorsal / posterior location with increasing age and accuracy during interference.
Activation strength of the task-relevant-network component correlated with response accuracy for caffeine yet not for placebo , indicating a selective cognitive effect of caffeine.
Active adenomyosis has been found in pre- and peri-menopausal women and in postmenopausal women receiving tamoxifen.
Active ageing and successful ageing are ubiquitous concepts in contemporary societies.
Active ageing is a policy tool that dominates the way the ageing society has been constituted during the last decades.
Active ageing is one of the most important issues taken up by the WHO in regard to ageing societies.
Active ageing is quite a recent concept and indicates an attitude towards ageing that enhances the quality of life as people become older.
Active and sedentary behaviors were recorded by standardized questionnaires.
Active and sedentary behaviors were recorded by standardized questionnaires.
Active Aβ42 peptide immunization in humans had led to an inflammatory autoimmune response , and the trial was stopped.
Active Caspase-6 is abundant in the neuropil threads , neuritic plaques and neurofibrillary tangles of Alzheimer disease brains.
Active DNA Aβ42 immunizations administered with the gene gun into the skin elicits a different immune response and is non-inflammatory.
Active engagement in life is a critical factor for successful aging.
Active lifestyles might protect cognitive abilities ; however , studies rarely consider the reverse causal direction.
Active MS plaques predominate in acute and early RRMS and are the likely substrate of clinical attacks.
Active pharmacological research is directed towards selectively targeting the culprit venous cells.
Active principles in mouthwashes were mainly quaternary ammonium compounds ( @percent@ ) .
Active smokers were @percent@ , ex-smokers @percent@ and non-smokers @percent@.
Active subjects with higher intakes of animal or plant protein-source foods had @percent@ lowest risks of functional decline.
Active treatment ( compared to placebo ) , and particularly the patch and lozenge combination , promoted early quitting.
Active treatment was T. foenum-graecum de-husked seed extract , @number@ mg per day for @number@ weeks.
Activin receptor-like kinase5 ( ALK5 ) inhibitors antagonize TGF-β signalling by blocking TGF-β receptor-activated Smad ( R-Smad ) phosphorylation.
Activities from all five Italian reference sites are presented with different good practices and scale-up approaches for improving health in ageing population.
Activities of antioxidative enzymes , malondialdehyde ( MDA ) content in serums and livers of aging mice were evaluated.
Activities of daily living ( ADL ) , IADL , and the MMSE were also measured.
Activities of daily living and quality of life of both groups improved , but the differences of being allocated a home help were significant.
Activities of daily living defined disability.
Activities of daily living is an important determinant of care costs.
Activities of daily living , quality of life and home-help allocation were assessed at the baseline and after @number@ weeks.
Activities of daily living scores differed across the four groups , with those in the non-drug treatment group being the most disabled.
Activities participated in were categorised into @number@ domains of physical , cognitive , social , prosocial , spiritual , and recreational activities.
Activities related to the management of aging in Poland are still taken to a small extent.
Activities that fostered study engagement were associated with increased home visit participation.
Activities to increase patient compliance to auditory training protocols are proposed.
Activities were included in the protocol because they could represent other activities of similar patterns and because they could be actually performed , not simulated.
Activities were measured at baseline.
Activity and sleep were recorded through actigraphy in @number@ veterans ( @number@ resilient and @number@ nonresilient ) for @number@ days.
Activity-cognition associations might reflect stable intelligence differences rather than a protective effect of activity.
Activity-dependent effects of early sensory deprivation and long-term practice are superimposed on normal maturation and aging.
Activity in the amygdala and hippocampus decreased with age when processing emotional salient stimuli versus neutral stimuli.
Activity in the anterior MTL during Repeated stimuli was inversely related to performance in post-scan associative recognition for the Novel face-name pairs.
Activity in the left dorsal medial prefrontal cortex supported subsequent source memory in both age groups for the self-referenced relative to the other-referenced items.
Activity in the left hippocampus was significantly modulated by task difficulty in the elderly participants.
Activity in these frontoparietal regions correlated with performance in the older group.
Activity is also viewed as respite , difficult , and has no meaning for care recipient.
Activity level measures included the Berg Balance Scale , Goal Attainment Scaling ( GAS ) , and the FIM.
Activity levels are summarized and graphically displayed for easy interpretation.
Activity levels did not significantly differ between days or hours of the day ( P > @number@ ) .
Activity levels were recorded on a wrist actigraphy device.
Activity level was determined with accelerometry ( ActivPAL ) .
Activity level was measured using ActivPAL accelerometers , and CRP levels were obtained from blood samples.
Activity limitations and social restrictions were also reported in a few cases.
Activity limitations were defined by the receipt of help in any of @number@ activities of daily living / instrumental activities of daily living.
ACTIVITY OBJECTIVE @number@
Activity of ( 99m ) Tc-RAFT-RGD and capillary fluorescence labeling indicated that new formed capillaries were functional.
Activity of daily living limitations improved in @percent@ of the first @number@ people who completed the intervention.
Activity of daily living was assessed by the Instrumental Activities of Daily Living Scale and life events were evaluated by the Life Event Scale.
Activity of ( R , R' ) -MNF positively correlated with the β2-AR expression levels across tested cell lines.
Activity profiles were subsequently associated with self-rated health and depression symptoms.
Activity reduction measures were moderately reliable ( around @number@ ) but still showed reasonable agreement.
Activity rhythms were measured objectively with actigraphy.
Activity rhythms were quantified calculating the fragmentation of the rhythm , stability of the rhythm over days , and timing of the rhythm.
Acto-myosin contractility in carcinoma-associated fibroblasts leads to assembly of the tumor extracellular matrix.
Actoxumab and bezlotoxumab are human monoclonal antibodies against C. difficile toxins A and B , respectively.
ActRIIB.Fc effectively blocked and reversed loss of body weight , lean mass , and fat mass in juvenile SIV-infected rhesus macaques.
Actual fat loss is an illusion created by the inter-relationship of the different tissue types.
Actual health care use patterns will become evident as systemic changes are realized-or not-over time.
Actually , antiretroviral therapy may be frequently accompanied by immunological unresponsiveness , persistent inflammatory conditions and inefficient cytotoxic T-cell response.
Actually , there is a disagreement as to whether there is a causal or coincidental relationship between ELF-EMF exposure and leukemia development.
Actual maximal reach was then measured.
Actual use of patients is higher than those of professionals but very variable.
A cumulative effect of socioeconomic factors was computed by considering the association for each study and the number of available studies.
A cumulative index score was calculated based on the number of highest tertiles of these @number@ stress markers.
A Cumulative Logit Model was established to identify factors that were associated with pore widening.
Acupuncture is one of the main healing arts in Oriental medicine.
Acupuncture may offer an alternative treatment that promotes adult neurogenesis through the expression of NTFs in the brain.
A current challenge is to identify specific sirtuin target proteins against the high background of acetylated proteins recently identified by proteomic surveys.
A current model suggests that genomic instability plays a major part in the pathophysiology of some lamin-related diseases.
A custom Asian exome-chip was used to detect genetic determinants influencing circulating FGF21 levels.
A custom-developed laser ray tracing aberrometer was used to measure the optical aberrations.
A customised wheelchair data logger was attached to each participant's wheelchair for @number@ month.
A customized panel was designed to capture @number@ known causative genes , including @number@ autosomal dominant SCA genes and @number@ dementia-related genes.
A custom-made magnet array , matching well-to-well to a 24-well plate , was generated and characterized.
A custom reciprocating saw with variable stroke length was used to conduct a three-factor design of experiments.
Acute aerobic exercise increases reactive oxygen species and could potentially damage proteins , but exercise training ( ET ) enhances mitochondrial respiration irrespective of age.
Acute and chronic injuries attributed to PRT have been cited in the epidemiological literature.
Acute and chronic management consists in the control of hyperammonemia with protein-restricted diet supplemented with citrulline / arginine and ammonia scavengers.
Acute and chronic renal failure is more common in adult PWH than in general population.
Acute bouts of moderate aerobic exercise have been shown to improve cognitive function in healthy adults.
Acute cholecystitis was present in @number@ % , acute pancreatitis in @number@ % , and acute cholangitis in @number@ %.
Acute clinical signs include intermittent episodes of vomiting , confusion or coma and hepatitis-like attacks.
Acute coronary syndrome ( ACS ) is one of the main causes of cardiovascular death.
Acute coronary syndrome causes greater morbidity and mortality in this group of older patients , which appears to be due to age-related comorbidities.
Acute CS appeared to have subtle time-dependent effects on CORT levels but more pronounced effects on 5HT.
Acute diarrhea leads to a substantial disease burden among the elderly worldwide.
Acute exacerbations become more frequent and more severe as the disease reaches end-stage.
Acute exercise improved sleep continuity by decreasing total wake time.
Acute exercise increases insulin sensitivity in skeletal muscle ; however , whether mitochondria are involved in these processes remains unclear.
Acute exercise triggered increases in circulating free fatty acids and lactate levels both at baseline and after the intervention ( P < 0.05 ) .
Acute heart failure ( HF ) is a prevalent disease with important socio-economic repercussions.
Acute hypoxia activated an insufficient antioxidant defense response as suggested by the oxidative damage observed.
Acute hypoxic exposure increases vascular thrombotic risk.
Acute increases occurred in serum testosterone concentrations due to resistance exercises but basal testosterone remained unaltered.
Acute inflammation causes additional decrements in vascular function , but these responses are not uniform in older compared with younger adults.
Acute inflammation may impact ventricular-vascular coupling and predispose older adults to cardiovascular events.
Acute inflammation of the forestomach occurred in four @number@ g / kg females.
Acute inhibition of angiotensin-converting enzyme with ramipril did not suppress this improved glucose tolerance profile.
Acute injuries should be further categorized as emergent or nonemergent.
Acute ischemic stroke represents a severe form of metabolic stress that activates many pathological processes and thereby impairs cellular functions.
Acute kidney injury ( AKI ) is a major health care condition with limited current treatment options.
Acute kidney injury is a sudden decrease in kidney function with or without kidney damage , occurring over a few hours or days.
Acute lymphoblastic leukemia ( ALL ) in adults is a rare disease.
Acute lymphoblast leukemia ( ALL ) is characterized by overproduction of immature white blood cells in the bone marrow.
Acute muscle injury and physiological stress from chronic muscle diseases and aging lead to impairment of skeletal muscle function.
Acute-onset and long-term dizzy patients were comparable in many aspects , which makes this classification less clinically important.
Acute oxidant insult caused up-regulation of p21 expression to levels comparable to senescent cells.
Acute oxidative stress led to a marked increase in autophagy in the RPE , whereas autophagy was reduced under chronic oxidative stress.
Acute pain is reported by patients with osteoporosis-related fractures , but chronic pain , mainly back pain , is also a characteristic of severe osteoporosis.
Acute psychosocial stress activates the physiological and endocrine stress systems and increases the subjective emotional experience of stress.
Acute renal failure in elderly patients is common and likely to become more so as life expectancy in France continues to grow.
Acute respiratory distress syndrome ( ARDS ) is a devastating critical illness disproportionately affecting the elderly population , with both higher incidence and mortality.
Acute stroke or transient ischaemic attack ( TIA ) should be treated as a medical emergency and evaluated with minimum delay.
A cut-off level for the diagnosis of chronic pancreatitis was defined by testing receiver operating characteristics curves.
A cut-off score equal to or above @number@ on the scale denoted psychological distress.
A cut-off value of AFC , AMH , and FSH for poor responders was plotted at the 50th percentile of each normogram.
A cut-off value of @number@ is suggested as a possible diagnostic criterion for diffuse chronic pancreatitis.
A cutting rate model was developed by regression analysis of the experimental data and validated through additional experiments.
Acvr1 acts as a tumor suppressor in the lens.
AC was significantly lower in the MPS-severe group compared with both the CTL and the MPS-mild groups.
A cystatin C variant associated with increased risk of developing AMD and Alzheimer's disease ( AD ) presents reduced secretion levels from RPE.
A cytoskeletal structure similar to that observed in methylated cells was induced.
Ad36 , a human adenovirus , increases TNFα and MCP1 mRNA in adipose tissue , yet improves glycemic control in mice.
Ad36 and E4orf1 both enhance cellular glucose uptake even in presence of inflammation.
Ad36 or E4orf1 up-regulated AKT-phosphorylation and Glut4 and increased glucose uptake ( P < @number@ ) in the presence of MCP1 or TNFα.
Ad36 via its E4orf1 gene , up-regulates AKT / glucose transporter ( Glut ) -4 signaling to enhance cellular glucose uptake.
A daily illness log was kept for each child.
ADAMS , a resource-intense sub-study of the Health and Retirement Study , was designed to provide diagnostic accuracy among persons with more advanced dementia.
ADAMS obtained direct estimates by relying on probability sampling nationwide.
ADAMS participants were aged @number@ and older drawn from the nationally representative Health and Retirement Study.
ADAMTS-13 cleaves von Willebrand factor multimers , and inhibits thrombus formation and , seemingly , inflammatory reactions.
ADAMTS-13 did not show any significant effect on vasospasm.
ADAMTS-13 neither increased the amount of subarachnoid blood nor prolonged the bleeding time.
ADAMTS-13 reduced the amount of apoptotic and degenerative neurons.
AD and HF are both debilitating and life-threatening conditions , affecting enormous patient populations.
AD and LLD led to brain atrophy in networks only partially overlapping.
AD and vascular dementia ( VaD ) were diagnosed by NINCDS-ADRDA and NINDS-AIREN.
Adaptation and de-adaptation rates were quantified separately for temporal and spatial parameters.
Adaptation influences perception not only of simple stimulus qualities such as motion or colour , but also of complex stimuli such as faces.
Adaptation requires intensive collaboration with participants and cultural brokers in the community.
Adaptations are made by local staff delivering the program.
Adaptation to obtain a food bolus ready to be swallowed relies on variations in number of cycles , muscle strength and volume of emitted saliva.
Adaptation to stress is identified as one of the seven pillars of aging research.
Adapted cut-off values lowered the proportion of abnormal results to @percent@ ( quintile-based approach ) and @percent@ ( z-score approach ) .
Adapted physical activity is different for men and women , for different age , as well as for the individuals.
Adapted physical activity represents physical activity individually tailored according to the psychosomatic capabilities of a person and the goal to be achieved.
Adapted strategies in EDs to adjust diagnostic and treatment strategies for this population are thus warranted.
Adapted thresholds are needed for specific populations.
Adapting cosmetic treatment to male grooming routines increases compliance.
Adapting to disability and limitations caused by an illness is very difficult for many patients.
Adapting to young or old faces induced opposite linear shifts in perceived age that were independent of the model's age.
Adaptive and innate immune mechanisms are often directed outward , protecting self against pathogens.
Adaptive and maladaptive responses to redox stress may involve mitochondrial channels such as mPTP and inner membrane anion channel ( IMAC ) .
Adaptive immune activation and immunosenescence are associated with comorbidities and mortality in the general population but are less predictive in HIV-infected patients.
Adaptive signals by themselves cannot upregulate T-bet ; however , they have a synergistic effect on induction of T-bet by innate receptors.
Adaptogens are stress-response modifiers that increase an organism's nonspecific resistance to stress by increasing its ability to adapt and survive.
AD as compared to NA participants were impaired in all tests except the Stroop test.
AD Assessment Scale , the cognitive subscale , was used to evaluate cognitive functioning in the elderly participants.
A data-driven staging procedure was then created based on patterns of WMSA scaling and specific regional cut-off values from the quartile analyses.
A data set of @number@ cases and @number@ sleep-clinic patients was used for the validation.
A data set of @number@ patients and @number@ sex- and age-matched controls was used for the training.
A day before this experiment was carried out , pre-test data were collected using leisure competence and stress scales.
AD biomarkers do not evolve in an identical manner but rather in a sequential but temporally overlapping manner.
AD biomarker status was determined by positron emission tomography-Pittsburgh compound B ( PET-PiB ) imaging and cerebrospinal fluid ( CSF ) levels of Aβ42.
AD biomarkers were measured with a composite score composed of measures of amyloid , phosphorylated tau , and neurodegeneration.
AD brains showed increased nicotinamide adenine dinucleotide phosphate ( NADPH ) production in areas affected by disease.
ADC values increase with age during childhood not only in normal kidneys but also in kidneys with VUR.
A DDD > 1 °C was associated with a reduced recovery rate.
Added bran and germ should be reported distinctly from whole grains.
Adding a FIT to a once-only screening FS would substantially increase sensitivity of CRC screening at a modest loss in specificity.
Adding a multibiomarker risk score may improve discriminatory ability.
Adding APOE ε4 carrier status improved the model ( p = @number@ ) .
Adding CP to the VD definition leaded to higher VD prevalence ( @percent@ ) .
Adding environmental information resulted in a lower cost-effectiveness.
Adding information on long hours to traditional risk factors for CHD may help to improve risk prediction for this condition.
Adding leg extensor power and standing balance into the model increased the variation explained to @percent@.
Adding rural residence and age to disability creates a triple threat in terms of potential health disparities.
Adding the model of \ "reverse mentoring \ " may be key in engaging these professionals.
Adding the PA to the MTA scale improved discrimination of AD from FTLD , and early-onset AD from normal aging.
Adding the removal of infected cells by natural killer cells did not improve the model fit in either young or aged animals.
Adding years to life and life to years may require two distinct and different approaches , one physical and the other psychological.
Additional actions via nuclear receptors and other binding sites are likely.
Additional adjustment for circulating immune mediators or the use of anti-inflammatory medication had hardly any impact on the observed ORs.
Additional adjustment for potential mediators including PTH only slightly attenuated these associations.
Additional adjustment for putative mediators , including subclinical CVD , diabetes , lipids and inflammation , did not significantly affect these estimates.
Additional adjustment for trunk STFFM that partially accounts for high-metabolic rate organs did not affect this association.
Additional adjustments did not change these results.
Additional adjustments for apolipoprotein genotype , smoking , comorbidity index , and cognitive performance did not change the associations.
Additional age-related differences in blood-oxygen level-dependent response were observed in the medial temporal lobes of H1 homozygotes with PD.
Additional age structure analysis was performed to geodemographics segmentation to explore the relationship between influenza and family structure.
Additional aging-associated mechanisms for cognitive decline such as diabetes and synapse loss have been linked to AD and these hypotheses are discussed.
Additional aims of this study were to investigate whether the levels of KL-6 in plasma and sputum are related to ageing and smoking history.
Additional aim was to elucidate the possible source of maximal exercise-induced increase in MMP-9 concentration.
Additional analogous regressions were performed for males and females.
Additional analyses correcting for follow-up duration and attrition showed lower performance scores for men and women with OA.
Additional analyses revealed that memory level and change were unrelated to changes in subjective age.
Additional analyses were conducted on complete ( nonimputed ) cases , excluding program participants who used the program for less than @number@ minutes.
Additional analysis of the mechanism of super p53-dependent apoptosis may lead to the identification of novel drug targets for cancer therapy.
Additional analysis on axial diffusion and radial diffusion measures suggest that demyelination may be the main mechanism underlying the observed microstructural impairments.
Additional anatomic dissection was performed in @number@ hands of five fresh cadavers to establish the anatomic basis for the targeted restoration technique.
Additional ANS binding is triggered by hyperthermia , thermal lesioning , proteasome inhibition , and induction of ER stress.
Additional antihypertensives are added to achieve this goal if needed.
Additional articles were searched by citation search , author search , and reference lists of relevant articles.
Additional assistance may be necessary to help veterans cope with their pain.
Additional basic science and clinical studies are needed to confirm this preliminary report.
Additional benefits included ongoing access to mentorship and training , plus sustained engagement in local and statewide HIV care networks.
Additional benefits in vitality were achieved by exercising @date@ / week.
Additional bivariate predictors of surgical admission were intact mental status , having private insurance , and higher education.
Additional changes in microglia occur with AD including Iba1 protein puncta and discontinuity.
Additional clinical research on the vaccines on women outside the currently approved age ranges and in males is necessary.
Additional cohort studies are needed to confirm these findings.
Additional common skin conditions of concern in men of color include pseudofolliculitis barbae , acne keloidalis nuchae , and keloids.
Additional comorbid EjDs ( ie , anejaculation , perceived decrease in ejaculate volume , and decreased force of ejaculation ) were recorded.
Additional components , and in particular experience , appear to play a fundamental roles in hippocampal functions.
Additional conditions that impact upon achieving glycemic control will also be discussed.
Additional controlling for vascular risk and protective factors , WML , and APOE status did not modify the results.
Additional correlation analyses between ACC and RT suggested that moderately intoxicated older adults become more accurate as response times increase.
Additional covariates included demographics and co-morbidities.
Additional CT and MR imaging was performed to confirm results.
Additional cytokine gene polymorphisms were assessed and innate immunity genes were analyzed for possible relevance in longevity.
Additional data abstracted included amyloid positron emission tomography , Apolipoprotein E genotype , coexisting cerebral microbleeds , and extent of SS.
Additional data are needed to reach a definitive conclusion.
Additional data on other clinical markers were obtained from patient records in the intensive care unit.
Additional data stratified by age group , education , and cognitive impairment are provided in the Supplemental data.
Additional decrements in muscle growth factors compromise skeletal muscle growth , differentiation , survival and regeneration.
Additional diagnostic elements include eosinophilic airway and systemic inflammation , a good response to corticosteroid treatment , and a high concentration of exhaled nitric oxide.
Additional efficacy end points and safety / adverse events ( AEs ) were evaluated.
Additional efficacy end points , patient-reported outcomes , and safety / adverse events ( AEs ) were evaluated.
Additional effort is required to define response to OBT-A and to establish optimal treatment duration.
Additional efforts to prevent potential downstream mediators through which delirium increases mortality may help to improve outcomes among hospitalized older adults.
Additional endpoints of feasibility ( accrual , participation , retention , compliance , and safety ) are reported.
Additional evidence for the efficacy of the CR program was found by comparing responses on a SRI of cognitive ability between the two groups.
Additional evidence of construct validity was obtained via examination of correlations with other measures of related constructs.
Additional evidence regarding older adults is required.
Additional exploration is needed to elucidate the potential protective role of vitamin D and its contribution to reducing visual loss.
Additional factors of relevance to middle-aged women are menopausal status and aging anxiety , which reflect the distinct developmental challenges faced by women during midlife.
Additional fall prevention studies should focus on motor-cognitive performance and reinforce outcomes of task managing strategies.
Additional findings indicated stimulation of the dermal fibroblasts with increased collagen synthesis.
Additional findings suggest that the NICD and HIF-1α collaborate to engage pro-inflammatory and apoptotic signaling pathways in stroke.
Additional functions of autophagy in immune responses and carcinogenesis may also contribute to the development of NASH and its complications.
Additional groups of @number@ male and @number@ female special study rats were administered the same doses for @number@ days.
Additional groups received apple juice concentrate ( AJC ) diluted to @percent@ ( vol / vol ) in their sole source of drinking water.
Additional healthcare disciplines may be involved for specific interventions.
Additional high quality empirical research is necessary to understand the risks to health of women aging with disabilities.
Additional high-quality trials are needed to strengthen support for their use.
Additional hormonal examinations revealed low values for other anterior pituitary hormones.
Additional imaging for masked assessments and live assessments were completed at @number@ and @number@ days.
Additional implications as they are related to early developing regulatory aspects of temperament are discussed.
Additional infection with latent pathogens such as cytomegalovirus aggravates this process.
Additional information on early introduction of pre- and post-lacteal feeds and on first foods and beverages was included.
Additional information was collected from patients and charts review during hospitalization.
Additional investigation of copper pathology in PD may identify novel targets for the development of protective therapies for this disorder.
Additional investigations are needed to understand the impact of other hormonally active compounds on dementia and cognitive outcomes.
Additional journals were found from the references in the initial search results.
Additional key factors were lack of local community supports as a barrier and leadership and structured workflow as facilitators.
Additional key players in the modification of the extracellular matrix are matrix metalloproteinases.
Additional linear regression models were conducted with interaction terms for education × brain volume and education × lacunar lesion volume.
Additional longitudinal studies are required to confirm these findings.
Additional longitudinal studies on both white and grey matter are warranted to further evaluate potential clinical utility.
Additional longitudinal study is needed to further evaluate structure-cognition relationships in older adulthood and across the adult lifespan.
Additional long-term controlled studies should further establish the role of clomiphene in LOH.
Additionally , 16·0% had a potential drug-disease interaction with 3·7% participants having one involving non-prescription medications.
Additionally , a 4-week , single center , clinical study was conducted on the photodamaged forearms of @number@ subjects.
Additionally , accelerometer metrics based on vertical axis counts and triaxial counts were compared.
Additionally , accumulation of insoluble , SDS-resistant proteins has been identified as an intrinsic property of organismal aging.
Additionally , accumulation of Treg in Bim-deficient mice occurred after the cells left the transitional recent thymic emigrant compartment.
Additionally , a concomitant and dramatic loss of medullary and cortical cells is observed in old animals.
Additionally , a control analysis performed on the default mode network confirmed that our age-related increases in functional connectivity were specific to the motor system.
Additionally , across a single short sampling session , measurements were relatively stable across three trials of MPTs.
Additionally , a decrease in the differences between dominant and non-dominant hand function with age was observed.
Additionally , a diet high in vegetables but low in cereal , meat , and dairy might be associated with longer LTL among healthy elderly.
Additionally , adiposity usually increases with aging and this could play a relevant role in the gradual impairment of insulin action.
Additionally , advanced age was an independent predictor of a complicated recovery and 28-day mortality.
Additionally , a frequency dependent behavior was observed between the two signals.
Additionally , after removal of the restorations , the implant-abutment interface of the fixtures was inspected using a scanning electron microscope ( SEM ) .
Additionally , age can modify the effect of other risk factors , necessitating identification of such interactions and the differentiation of effect modifiers from confounders.
Additionally , age-corrected concentrations of PCr in gray matter were significantly elevated in bipolar subjects ( p = 0.0048 ) .
Additionally , a genome-wide comparison of mRNA transcriptomes across species also revealed specific gene expression patterns in bats.
Additionally , age-related altered antigen presentation and decreased specific antibody responses might increase the risk of respiratory tract infections.
Additionally , age-related changes in pharmacokinetics and pharmacodynamics influence medication therapy.
Additionally , AGE-α-synuclein altered DNA integrity as evidenced by the melting temperature , ethidium bromide , and DNAse I sensitivity studies.
Additionally , a higher level of mental health care use was noted.
Additionally , a lactate level ≥ @number@ mmol / L was an independent predictor of major complications.
Additionally , a large meta-analysis was performed incorporating our data and previously published data.
Additionally , all obese children were evaluated for metabolic syndrome and insulin resistance.
Additionally , all patients received calcium @number@ mg / day.
Additionally , all seven showed mild to moderate tau inclusion burden : five cases lacked β-amyloid pathology and two cases had Alzheimer's pathology.
Additionally , all stimuli were presented in gradually masked versions to alter stimulus completeness.
Additionally , all subtypes showed similar trajectories across five years.
Additionally , an age-dependent decrease in Cisd2 expression has been detected during normal aging.
Additionally , an age-dependent decrease of Cisd2 expression has been detected during normal aging in mice.
Additionally and interestingly , germline mutations of the same gene have been involved in familial polyposis and colorectal cancer ( CRC ) predisposition.
Additionally , a need to save strength / energy was also a reason for not participating in the activities.
Additionally , an elderly individual can be modeled which will provide insight into muscle function as we age.
Additionally , annual seasonality is found to be an important environmental factor influencing cytokine production.
Additionally , antibiotic resistance may complicate a therapy.
Additionally , a possible age and / or hearing loss related effect on the neural correlates of listening effort was investigated.
Additionally , a reciprocal relationship between these pro-inflammatory TH17 and the anti-inflammatory regulatory T cells ( Tregs ) has been described.
Additionally , a reduced P300 component amplitude was observed for older adults relative to young.
Additionally , a State Space Grid approach was used to study personalized changes in symptom profiles.
Additionally , a subset of subjects participated in a behavioral experiment to assess perceptual discriminability of face identity.
Additionally , a suggestive trend for association with reduced testicular volume was observed among young men , and with lower serum FSH among infertility patients.
Additionally a sustained P3a across frontal and central electrodes occurred only in middle age adults indicating the recruitment of frontal activity.
Additionally , attentional processes affecting the correlation between WM performance and neurofunctional activation seem to be different between incipient AD and healthy aging.
Additionally , attractive signals are released from dying cells to recruit phagocytes to sites of death.
Additionally , Aβ binds more efficiently to cells expressing activated α2 integrin.
Additionally , Aβ-degrading peptidases located in lipid rafts , such as neprilysin , appear to play a role in Aβ catabolism.
Additionally , BC patients with elevated levels of ADAR1 show low survival.
Additionally , better performance on executive functioning tasks was associated with increased use of external memory strategies.
Additionally , blinded randomized clinical trials showed firm evidence of extra cytoreduction by local chemotherapy in the tumor cavity.
Additionally , blood samples from CRC cases recruited in a clinical setting were collected.
Additionally , BMI was positively associated with LINE-1 methylation ( P trend = @number@ ) .
Additionally , both site- and region-specific analyses revealed DNA methylation patterns unique to Nicoyans.
Additionally , both systems have been implicated in the etiopathogenesis of many age-related diseases , particularly neurodegenerative disorders , such as Alzheimer's and Parkinson's disease.
Additionally , both types of anesthetics do not lead to oxidative DNA damage in patients without comorbidities undergoing minimally invasive surgery.
Additionally , brachial artery shear rate patterns were associated with brachial artery IMT in @number@ middle-aged and older individuals.
Additionally , careful identification of commonalities among the strains may lead to the identification of fundamental pathways of aging.
Additionally , carers were administered a questionnaire including patient's and caregiver's demographics.
Additionally , caudate activation is associated with improved accuracy and VLPFC activation with faster reaction times in the full sample.
Additionally , cellular and molecular mechanisms of general aging have been suggested to play a vital role in ovarian aging.
Additionally , cellular homeostatic processes including the ubiquitin-proteasome system and mitophagy are impacted by oxidative stress.
Additionally , centenarians in both groups had lower neuroticism and higher conscientiousness than the US adult population.
Additionally , change in exercise was not associated with weight-related outcomes in mothers or daughters.
Additionally , characteristics of the study population including age , gender , ethnicity and menopausal status appear to be mediating variables.
Additionally , concentration of CRP , as a marker of inflammation , was measured.
Additionally , consumers rated each palatability trait as either acceptable or unacceptable.
Additionally , correlations among amyloid burden , SVD , and cognition were made.
Additionally , cortex and cerebellum of @number@ mice sacrificed between day @number@ and @number@ after birth were investigated.
Additionally , creatine supplementation plus resistance training results in a greater increase in bone mineral density than resistance training alone.
Additionally , cubic splines were used to assess dose-response associations.
Additionally , current-smokers have a higher AWT , possibly due to remodeling or inflammation.
Additionally , deliberate oxidative labeling is used to probe protein structure and protein-ligand interactions in hydroxyl radical protein footprinting ( HRPF ) .
Additionally , descriptors are suggested for fractional treatments , fat melting , and cellulite reduction.
Additionally , detraining effects will be measured @number@ weeks after program cessation.
Additionally , DHAvD attenuated UVB-induced phosphorylation of MAPKs , activation of NF-κB and AP-1.
Additionally , diets on the day of dialysis and on nondialysis days were evaluated.
Additionally , differences in age composition between populations used to develop the methods and Thais may lead to an increase in error.
Additionally , differentiated processing of negative events but not positive events was positively related to openness and predictive of well-being.
Additionally , digigait analysis shows these mice develop an abnormal gait by @number@ months of age.
Additionally , dignity remained a significant predictor of elder satisfaction with staff.
Additionally , distribution into the brain , sex considerations and potential pharmacodynamic alterations in older people with dementia are discussed.
Additionally , during normal aging and in AD , the permeability of the brain barriers increase.
Additionally , each subject performed several muscle performance tests , and MMG of the quadriceps was assessed during a knee extension exercise.
Additionally , education correlated with attentional pattern to decision-relevant information.
Additionally , EF impairment was associated with worse performance on the TUG ( p < 0.0001 ) .
Additionally , employee well-being was examined as an outcome in this model.
Additionally , endothelial progenitor cell ( EPC ) counts , which are partially NO-dependent , were evaluated.
Additionally , epidemiological surveys provide information regarding the detrimental role of hypogonadism on mental well-being.
Additionally , ethnicity significantly affects the relationship between leisure activities and both emotional and cognitive health.
Additionally , excessive carbohydrate intake can contribute to the exacerbation of many different diseases.
Additionally , exercise protocols were extensively different , and generally lacked reporting measures.
Additionally , experimental conditions can be properly controlled during a shorter course of disease for SIV infection.
Additionally , exposure of normal cells to conditioned media from senescent cells doubled PAFr levels and pneumococcal adherence.
Additionally , facial wrinkles were classified and subjects scored their satisfaction and sensations.
Additionally familism was found to be positively associated with both negative and positive aspects of caregiving.
Additionally , FBF responses to ACh were determined in the presence of ETA blockade.
Additionally , five semi-structured interviews were conducted with EFPs.
Additionally , FLNA-KO femora are tougher and more ductile than WT femora.
Additionally , focus group sessions were conducted in the Netherlands , United Kingdom and France.
Additionally , for the first time , we identified several variants and new subhaplogroups related to exceptional longevity.
Additionally , frail group had a decreased 2LV % pattern ( that reflects parasympathetic modulation ) in the symbolic analysis in comparison with non-frail group.
Additionally , frequency of church attendance was positively associated with continuous health insurance for women aged 51-64.
Additionally , from the provided results , a physician could group the elders by their degree of similarity influencing their care and treatment.
Additionally , functional lower extremity strength ( 5-chair-rises test ) , subjective health rating , and retrospective estimates of fall frequency were recorded.
Additionally , further studies on determinants of QOL in elderly kidney transplant recipients are also needed.
Additionally , GARLIC can be used to retrieve potential disease-causative genetic variants overlapping regulatory sequences of interest.
Additionally , genes are annotated with gene ontology annotation and microRNA / drug / compound target information.
Additionally , genetics studies provide evidence for a role in predisposing homozygous subjects of the general population to micro-albuminuria.
Additionally , GR / GPx ratio was higher in healthy aged subjects , intermediate in MCI and lower in AD patients.
Additionally , half the specimens of each group were thermocycled ( @number@ cycles between 5-55ºC ) ( TC ) .
Additionally , haplotype-based analyses revealed an association between haplotype rs11218340-A / rs3824966-G / rs3824968-A and higher CSF-tau and CSF-tau phosphorylated at threonine @number@
Additionally , HBP subjects were separated in BP-related subgroups.
Additionally , healthy aging was characterized by a power increase in low-frequency bands.
Additionally , heritability was estimated in @number@ cohorts.
Additionally , HERRA is applicable to time-to-event or age-at-onset outcome , which , to our knowledge , no existing method can handle.
Additionally , HF-A group exhibited fewer the enhancements of VO ( 2peak ) and OUES caused by AIT than HF-NA group did.
Additionally , higher age was associated with shorter ECT courses regardless of the dosing method.
Additionally , higher fibre alignment was observed in the glaucomatous inferior-temporal LC ( p < @number@ ) .
Additionally , hormones and biochemical markers changed significantly over time.
Additionally , hyaluronidase , elastase , collagenase , and MMP-1 activities were significantly inhibited by E-AP-SM2001.
Additionally , hyper-osmotic and iso-osmotic stimuli conditions were adverse factors for IVD cells.
Additionally , if miss-classification costs are not symmetric , thresholds can be set to achieve either strong specificity or sensitivity scores.
Additionally , immunocytochemical analysis showed very little co-localization between presenilin @number@ and Tom20 , a marker protein of mitochondria.
Additionally , impact of telomerase deficiency in enacting skeletal aging phenotype and its associated microenvironment is also discussed.
Additionally , in active younger men CAT , GPx , and GR activities were higher than in sedentary ones.
Additionally , in a morphological study , the cytotoxic effect was observed in the cell organelles , especially the mitochondria.
Additionally , increased numbers of mature-type CD8 , CD11b-expressing dendritic cells were detected in mucosal inductive and effector lymphoid tissues of aged mice.
Additionally , increased plasma cholecystokinin concentrations in healthy old subjects may also contribute to the loss of appetite characteristic for the elderly.
Additionally increased WC was independently associated with lower mortality from cardiovascular diseases ( HR @number@ CI95% @number@.34-0.95 ; p < 0.030 ) .
Additionally , independent measures of executive function accounted for the association between RT metrics and WHM.
Additionally , individual differences in the baseline ALFF were correlated with intervention-related changes in behavioral performance.
Additionally , information on certain herbal products is either misleading , or simply unavailable.
Additionally , information on socio-demographic factors , medical conditions , depressive symptoms , disability , and cognitive function were obtained.
Additionally , interactions among attention networks were examined.
Additionally , in the second wave , we investigated the issue of discrimination and quality of life.
Additionally , introduction of the three missense mutations from the affected subjects into Saccharomyces cerevisiae provided functional evidence to support their pathogenicity.
Additionally , investigators have successfully reprogrammed somatic nuclei into a pluripotent state by inserting them into ESCs or oocytes.
Additionally , iron overload and related neurodegeneration may also occur during aging , but the functional consequences are not clear.
Additionally , irregular ovarian AGE signaling might in part explain the abnormal ovarian histology observed in women with PCOS.
Additionally , it exerts effects on peripheral oscillators , including phase coupling of parallel cellular clocks based on alternate use of core oscillator proteins.
Additionally , it reinforces the recommendation to measure WC in clinical practice , especially when BMI is below obese ranges.
Additionally , it takes an important step forward in clarifying the role of different factors in understanding age effects across these different contexts.
Additionally , it was questioned whether the subjective evaluation of the time one has left to live affects this relationship.
Additionally , LADH activities were measured after in-vitro HNE-treatment to mice brains.
Additionally , levels of several neuropeptides co-expressed with GAD decrease during aging.
Additionally , LOC100129148 enhanced the KLF12 expression through functioning as a competitive ' sponge ' for miR-539-5p.
Additionally , longitudinal structural MRI and DAT scan data were included.
Additionally , long-term low-level exposure to arsenic was significantly correlated to poorer scores in global cognition , processing speed and immediate memory.
Additionally , lower expression levels of miR-378a-3p were associated with poor prognosis for tamoxifen-treated patients with breast cancer.
Additionally , low-income individuals did not refrain from applying.
Additionally , markers of bone resorption and formation were measured at each visit.
Additionally , medial temporal lobe integrity correlated with better performance in rejecting distractors , but not in identifying targets , in the immediate paired-associate task.
Additionally , MetS subjects with longer RTL had greater homeostatic model assessment-β level and lower triglycerides plasma levels.
Additionally , micronutrient reference intakes were generally met.
Additionally , minimum requirements for the number of colonoscopies with @number@ or more detected adenomas were derived.
Additionally , mitochondrial dysfunction can be fatal.
Additionally , modifiable risk factors of AD have been identified and characterized.
Additionally , most studies focus on the oxidative profiles of professional athletes , but limited information is available for amateur athlete populations.
Additionally , mRNA expression of lipases was determined in biopsies from SCAAT.
Additionally , multilevel modelling was used to establish the isolated influence of area of residence on treatments.
Additionally , multivariate models were compiled for each dental index to evaluate possible confounders.
Additionally , muscle architectural parameters from elderly cadavers are lacking , making it difficult to accurately model elderly populations.
Additionally , MVPA predicted pain facilitation on the TS test , with greater MVPA associated with less TS of pain.
Additionally , NAP1L1 increases CSB processivity by decreasing the pausing probability during translocation.
Additionally , NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O ( @number@ ± @number@ vs @number@ ± @number@ P ≤ @number@ ) .
Additionally , NearDVA worsened at the faster speed ( p < @number@ ) .
Additionally , negative information about face recognition ability improved only older adults ' ability to recognise a previously seen face.
Additionally , NEP enzymatic activity and Aβ levels were also assessed.
Additionally , nitrosative stress induced apoptosis in cells expressing parkin , and this death was , at least in part , dependent upon p53.
Additionally , no prior study has described how regional WMSA volume scales with total global WMSA.
Additionally , no significant difference in the immune response was detected between the groups.
Additionally , no studies have examined white matter tract integrity in conjunction with neuropsychological evaluation associated with BMI among older adults.
Additionally , @number@ of the @number@ measured phosphatidylcholines were found to decrease.
Additionally , @number@ patients with renal resection were recruited as controls.
Additionally , @number@ unrelated participants with pure HSP of unknown genetic cause were screened.
Additionally , of the nine evolutionarily conserved putative splicing enhancer regions within exon @number@ two regions that flank rs688 were critical to exon @number@ inclusion.
Additionally , older adults with multiple chronic conditions ( MCC ) are often excluded because of recruiting and retention challenges.
Additionally , older participants showed an own-age bias and outperformed their younger counterparts with older stimuli.
Additionally , older subjects ' subsequent memory effects in right frontal cortex correlated positively with anterior callosal integrity and negatively with memory performance.
Additionally , original pharmacist DRP findings were compared with DRPs identified using the prescribing criteria.
Additionally , osteoporosis is becoming a serious public health issue in the Asia-Pacific and dementia is reaching epidemic proportions.
Additionally , our data could not show extensive neuronal or glial cell loss associated with aging , in contrast to other reports.
Additionally , our data support aging-induced changes of RNS levels in humans and rats in vivo.
Additionally , our data support that ORF2p amino acids @number@ and 1250- @date@ be involved in the reported ORF1p-mediated increase in ORF2p-driven Alu retrotransposition.
Additionally , our results challenge the hypothesis that Wnt signaling might be implicated in Aβ42 toxicity and might serve as a drug target against AD.
Additionally , our results indicate that the influence of light on clock-gene expression in humans is altered with age.
Additionally , our studies identify DNA-dependent protein kinase catalytic subunit ( DNAPKcs , also known as PRKDC ) as a downstream target of progerin.
Additionally , p16 gene plays a critical role in controlling aging , regulating cellular senescence , detection and maintenance of DNA damage.
Additionally , PA28αβ-knockout mutants achieved only half of the H2O2-induced adaptive increase in proteolytic capacity of wild-type controls.
Additionally , participants receiving treatment completed weekly practice logs and a posttreatment satisfaction questionnaire.
Additionally , participants were classified into those using only print materials and those using Web-based materials.
Additionally , participants were interviewed on experiences in using technologies since acquirement.
Additionally , patients ' quality of life and independence were found ameliorated after exercise sessions.
Additionally , performance of motor tasks becomes less accurate.
Additionally , photoexposed HDF displayed higher 11β-HSD1 mRNA expression than donor-matched photoprotected HDF.
Additionally , prevalence of hip fracture was significantly higher for MA women compared with NHW women.
Additionally , prospective follow-up over a period of 2-5 years was conducted.
Additionally , PSMB5 could enhance cell resistance to oxidative stress , as evidenced by the increased cell survival upon exposing senescent hBMSCs to hydrogen peroxide.
Additionally , public housing records , cognitive functioning , and general health status were assessed.
Additionally , RalGAP suppression in mammalian cells caused RalB-selective activation and Sec5- and exocyst-dependent engagement of mTORC1 and suppression of autophagy.
Additionally , randomized clinical trials demonstrated that ATV / c and ATV / ritonavir had comparable efficacy and safety profiles.
Additionally , Rb1 decreased eNOS acetylation , as well as promoted more NO production that was accompanied by an increase in Sirt1 expression.
Additionally , receiver operating characteristic analyses were performed for those measures that were significantly different between all groups.
Additionally , recent studies have highlighted the role of tissue resident mesenchymal cell populations as playing a central role in regulating regeneration.
Additionally , reconstructions generated to address specific scientific questions have the potential for continued investigations beyond the original reason for their acquisition.
Additionally , reduced attentional capacity in spatial processing was investigated in normal aging.
Additionally , reduce intake of several trace elements has been shown to be particularly challenging for elderly people.
Additionally , reliability across brain regions was more stable when three fMRI sessions were used in the ICC calculation relative to two fMRI sessions.
Additionally , renal cortical thickness was measured.
Additionally , researchers have identified a number of potentially beneficial clinical uses of creatine supplementation.
Additionally resveratrol increases mitochondrial biogenesis and has anti-inflammatory , anti-diabetic , and anti-cancer activity.
Additionally , reticulocyte count and oxidative stress were correlated with telomere length.
Additionally , ROCK activation resulted in mitochondrial dysfunction , whereas ROCK inactivation with Y-27632 induced the recovery of mitochondrial function.
Additionally , rs6521896 in BMP15 was associated with later menopause ( β = @number@ P = @number@ ) .
Additionally , SC hydration on the dorsal hand of aged females is also significantly lower as compared with young females.
Additionally , select executive impairments in shifting attention ( i.e. , reversal learning ) and in decision-making quality were revealed in HIV + participants.
Additionally , Selenium supplementation maintains the homeostasis of skin during chronological aging in our senescent skin equivalent model.
Additionally , serum MIC-1 / GDF15 levels were directly correlated with survival time independently of genetic background.
Additionally , several biomarkers of ageing were found by machine learning.
Additionally , several endocytic proteins were required for LRRK2-mediated protection against hydrogen peroxide.
Additionally , several questions for additional research are suggested from this study.
Additionally , significant differences were observed between a-MCI and AD patients in all tasks.
Additionally , silicone pores affected silicone color stability upon service.
Additionally , simulated maps of volume change are generated , which can be compared to maps estimated from real longitudinal data.
Additionally , Sirt1 overexpression decreased PrP ( 106-126 ) -induced Bax translocation to the mitochondria and cytochrome c release into the cytosol.
Additionally , skin ageing is also influenced by exogenous factors.
Additionally , skin of aged HOCl-treated mice acquired enhanced epidermal thickness and proliferation , comparable to skin in juvenile animals.
Additionally , skin resection is significantly reduced compared with that for primary rhytidectomy patients.
Additionally some individuals may develop a fulminant immune reconstitution syndrome.
Additionally , some of these effects were mediated by executive function.
Additionally , some typical apoptotic characteristics , such as chromatin condensation and an increase in the population of sub-G1 hypodiploid cells , were observed.
Additionally , S. sanguinis colonies obtained from both groups were inoculated on Prussian blue agar for H2O2 detection.
Additionally , SSTR1 co-localized with active-caspase-3 and bcl-2 around the hematoma.
Additionally , stalling of the progression of the transcription bubble with α-amanitin resulted in increased co-localization of CSB and NEIL2.
Additionally , strain differences in many of the behavioral tests suggest a role for genetic factors in the response to early life neglect.
Additionally , studies have shown that mice with specific genetic defects in folate metabolism and transport are more susceptible to arsenic-induced neural tube defects.
Additionally , studies in low- and middle-income countries are needed.
Additionally , telomere shortening may initiate the tumorigenesis of gastric carcinoma.
Additionally temporal extensions of the BNs for the modeling of regulatory time delays are incorporated.
Additionally , the absolute risk of malignancy and factors contributing to it were evaluated , and therapeutic patterns among the elderly were assessed.
Additionally , the accuracy of non-native speech sound production increased with age.
Additionally , the activity of lumbar muscles during the postural task was significantly higher in the pregnant women in comparison to the non-pregnant controls.
Additionally , the ageing classifier depicted that telomerase knock-out mice were older than their chronological age.
Additionally , the apoptosis of endothelial cells ( ECs ) increased in SAS-R tumor tissues when both Everolimus and radiation were administered.
Additionally , the associations between gait speed and chair stand time and the EQ-5D index were examined using the same analysis.
Additionally , the associations of gait speed and chair stand time with FEV1 and FVC were examined using multiple linear regression analysis.
Additionally , the association with cardiovascular disease demonstrates the BMD differences in groups are likely not due to glycemic control alone.
Additionally , the authors checked the references of the included studies for further relevant literature.
Additionally , the changes observed in correlation structure indicate a different angle of looking at treatment effects.
Additionally , the correlation between ED and LUTS was statistically significant ( P value < @number@ ) with coefficient of @number@
Additionally , the cost of the procedure was significantly reduced , with ALA and its application being the only expenses.
Additionally , the density , elastic modulus , and ultimate stress of the cancellous bone decreased with age.
Additionally , the effect of pre-diabetes on bone strength has not been well described.
Additionally , the effect of task focality on age differences was replicated.
Additionally , the effects of ginsenoside-Rg5 on the apoptosis of HeLa and MS751 cells were detected using DNA ladder assays and flow cytometry.
Additionally , the elderly often suffer from physical or cognitive disabilities that can prevent compliance with prescribed medications.
Additionally , the emergency physician must consider entities such as avascular necrosis , compartment syndrome , and muscular disruption.
Additionally , the evoked myoelectric signal ( M-wave ) and the myokinematic signal ( surface acceleration ) are measured.
Additionally , the excised tumors were scored for inflammatory cell infiltrates.
Additionally , the expression level of Sox2 can also be modulated transcriptionally , translationally or post-translationally.
Additionally , the expression levels of Pten , p16 , p21 and p53 also elevated with increased age.
Additionally , the extent of functional connectivity was positively correlated with working memory performance.
Additionally , the eye is a dynamic structure with connective tissue remodeling occurring as a result of aging and pathologies such as glaucoma and myopia.
Additionally , the factors related to profitability in home-visit nursing agencies in Japan have not been examined multilaterally and in detail.
Additionally , the %fat mass is increased only in S group ( p < @number@ ) .
Additionally , the groups did not differ on any syntactic measures for either task.
Additionally , the heart rate variability ( HRV ) was analyzed by R-R intervals in the frequency domain for the assessment of cardiac autonomic function.
Additionally , the immune response to most infections and vaccinations decreases with age.
Additionally , the impact of calorific restriction with its profound impact on cardiovascular and neuronal aging is addressed.
Additionally , the impact of temporal changes in the use and restriction of phthalates in children's products has not been assessed.
Additionally , the impact on intracellular signaling pathways was analyzed using a reporter cell line and Western blotting.
Additionally , the incidence of cognitive decline at @number@ months after surgery was identified.
Additionally , the index of acetabular dysplasia was lower in the atrophic type.
Additionally , the integrative conception was more frequent in individuals with higher levels of gratitude and wisdom.
Additionally , the investigators rated clinical improvement using five-point grading scales.
Additionally , the longitudinal sampling of nerve-T2-signal over larger areas of coverage has become technically feasible.
Additionally , the lower caloric density of plant-rich diets results in lower caloric intake with concomitant high intake of phytonutrients and antioxidants.
Additionally , the mid-point thickness and maximum thickness of the maxillary bone were measured.
Additionally , the motivation and deterrent factors are described indicating why the consumer does or does not purchase organic chicken.
Additionally , the muscular and nervous system also seem to play a regulatory role in bone homeostasis.
Additionally , the number of errors was counted for the one-legged tasks.
Additionally , the number of short instructions and instances of positive speech increased.
Additionally , the number of transient lower oesophageal sphincter relaxations is potentially increased in obese patients.
Additionally , the number of years of music training was associated with more accurate categorisation of the musical emotions examined here.
Additionally , the offspring of older parents are at significantly increased risk of cancer , diabetes , and neurodevelopmental disorders.
Additionally , the older networks were about equally as robust to random failures as younger counterpart , but more vulnerable against targeted attacks.
Additionally , the onset of mild hearing impairment decreased the social support score in men.
Additionally , the participants completed a polysomnography test to ascertain OSA ( defined as an apnoea-hypopnoea index ≥15 ) .
Additionally , the potential of these extracts to inhibit oxidative damage in human erythrocytes was evaluated by monitoring its biomarkers of oxidative stress.
Additionally , the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.
Additionally , the presence of health-related fears was specifically linked to fewer reported depressive symptoms.
Additionally , the presence of N- and C-terminal truncated alpha-synuclein species and fibrils were strongly reduced in double-transgenic mice when compared with single-transgenic A30P mice.
Additionally , the prevalence of accessory meatus in this population was @percent@.
Additionally , the prevalence of multiple RFs increases with age.
Additionally , there are accumulations of tau-protein as neurofibrillary tangles and dystrophic neurites.
Additionally , there has been a continuous interest in the use of melatonin as a marker for neoplasms of the pineal region.
Additionally , there is considerable interest in the contribution of NF-kappaB-mediated chronic inflammation in aging.
Additionally , the relationship between AV asynchrony detection skills and speech perception was assessed.
Additionally , the relationship between confidence and memory performance differed by age , with greater confidence related to more errors for young adults.
Additionally , the results indicate that the same radical surgical therapy is necessary for patients ≥ @number@ years old as in younger patients.
Additionally , there were no age effects in the magnitude of recollection-related modulations in regional activity or in the neural correlates of post-retrieval monitoring.
Additionally , there were no statistically significant differences between BR14 and at @number@ days of follow-up ( rehabilitation program ) ( R28 ) .
Additionally , there were several notable gender differences in chronic condition prevalence.
Additionally , the RFEI decreases indicate an additional adaptation to concurrent training.
Additionally , the risk of developing cardiovascular disease is increased with elevated visceral adipose distribution.
Additionally , the role of telomerase in stem cell driven cancer is also briefly touched upon.
Additionally , these entropy measures are heavily dependent on the predetermined parameters and confined to data length.
Additionally , these findings may have treatment implications because tumour cells lacking Lamin A / C exhibit more aggressive behaviour.
Additionally , these lesions were not readily detectable via Doppler ultrasound , computed tomography , or magnetic resonance imaging.
Additionally , these results can be used to support previous findings that ANL is not related to the intelligibility of the speech signal.
Additionally , these results may help identify those subjects at risk for future memory decline.
Additionally , these results suggest a link between AD pathology and white matter integrity disruption.
Additionally , these results were supplemented by a population-based retrospective cohort ( @number@ laparoscopic cholecystectomy ) in one community-based hospital area.
Additionally , the significance of body mass index ( BMI ) for correctly defining the COPs in a young , healthy reference group was assessed.
Additionally , the spatial extent of crowding was established by measuring spacing thresholds : the flanker-to-target separation required to produce a given reduction in performance.
Additionally , the specific influence of variable rhythmic grouping on temporal sensitivity was found to be greatest among older listeners.
Additionally , the study investigated the participant motivation for this type of training ( Exergaming ) .
Additionally , the temporal width of the AV asynchrony function was not correlated with speech perception skills for hearing-impaired individuals who use cochlear implants.
Additionally , the time-related effects of detraining are tested.
Additionally , the use of extended finite element modeling ( X-FEM ) allows for a detailed analysis of crack initiation and propagation in various materials.
Additionally , the vermis-posterior cinglate cortex ( PCC ) connectivity was positively correlated with depression severity.
Additionally , they also contribute towards immunosuppression and the formation of skin diseases including cancer.
Additionally , they are associated with an increased risk of multiple adverse outcomes including functional decline and death.
Additionally , they showed poorer physical performance ( GS and SW , P = @number@ and @number@ respectively ) than the normal group.
Additionally they were less likely to report their health as ' excellent' , were diabetic and were more likely to give responses suggestive of depression.
Additionally , the αA- ( 66-80 ) peptide shares the principal properties of amyloid peptides , such as β-sheet structure and fibril formation.
Additionally , those depressed were found to be @number@ times more likely to be hypertensive.
Additionally , to our knowledge , this is the first study to demonstrate an interactive effect of age and apathy on neuropsychological performance in HIV.
Additionally to the average use of AM , the factor variances and factor covariances among the three functions were examined across adulthood.
Additionally , trace and fractional anisotropy of the tensors were computed.
Additionally , training intensity can be increased by increasing the vertical acceleration load.
Additionally , transwell migration , invasion and transcriptional activity were assessed.
Additionally , treatment with a Notch ligand can mimic hypoxic responses.
Additionally trends over time illustrated the positive influence of interventions Guide Dogs have made to improve their workforce.
Additionally , twincretin is shown to improve upon the neurotrophic effects of single incretin receptor agonists in these same cells.
Additionally , two distinct patterns of functional connectivity were found.
Additionally , UC colocalized with Fib3 in distinct granules.
Additionally , we aimed to report the reference values for overall PA in a large sample of Norwegian older adults.
Additionally , we aim to identify the most effective form of presenting the related items.
Additionally we also collected data on demographic information , educational experience , blood pressure recordings from @number@ consecutive clinic visits.
Additionally , we also determined the epigenetic ages of @number@ individuals in a cohort consisting of 90-year-old participants ( nonagenarians ) .
Additionally , we analyze factors affecting elderly suicidal ideation and attempts as well as the paths of these effects.
Additionally we can study in in vitro conditions properties of the effluent dialysate on cultured peritoneal mesothelial cells or fibroblasts.
Additionally , we compare and contrast the epigenetic regulation of hypertension-induced reactive fibrogenesis and myocardial infarction-induced reparative or replacement cardiac fibrogenesis.
Additionally , we compared memory performance under these access and deletion functions to performance in their respective control conditions.
Additionally , we demonstrate that nucleosome remodeling by CSB consists of three distinct phases : activation , translocation and pausing , similar to ACF.
Additionally , we describe and review the major animal models of obesity , insulin resistance , metabolic syndrome and type @number@ diabetes mellitus.
Additionally , we determined rates of grey matter and white matter atrophy using automated deformation based morphometry.
Additionally , we determined that cotransfection of MRG15 with the known associated HAT Tip60 had a cooperative effect in activating the cdc2 promoter.
Additionally , we developed scoring systems based on predictors identified in the regression models.
Additionally , we discuss recent findings that evaluate the mechanisms by which reduced mTOR activity might benefit the aging brain in normal and pathological states.
Additionally , we estimated the relative importance of genetic and environmental sources of variance.
Additionally , we evaluated performance characteristics of different cardiac testing modalities.
Additionally , we find VDAC1 and VDAC3 are dispensable for the recruitment of p62 , mitochondrial clustering and mitophagy.
Additionally , we found that age significantly contributed to lower selenium concentrations in the peripheral membrane-bound and vesicular fractions.
Additionally , we found that interactions between the ADAMTS9 rs9985304 and ADAMTS9 rs76346246 SNPs influenced cognitive aging ( P < @number@ ) .
Additionally , we found that Mcl-1 levels were only transiently reduced by KRIBB11 : Mcl-1 levels were gradually restored as KRIBB11 activity diminished.
Additionally , we found that PPARγ acts upstream and regulates SETD8 expression in proliferating cells.
Additionally , we found that TOMM40 had effects independent of APOE e4 on both phenotypes.
Additionally , we have generated a stable SIRT4 knocked-down Huh7 cell line.
Additionally , we have identified a number of pluripotency-associated genes such as NANOG , LIN28 , POLR3G and NR5A2 as novel miR-27 targets.
Additionally , we have shown that the dendrimer helped to increase overall RSV loading and skin penetration of resveratrol.
Additionally , we identified sex differences in memory vividness : for both stimulus categories , women retrieved more vivid memories than men.
Additionally , we included age-dependent transcriptome data.
Additionally , we included a visual search task comprising Gabor stimuli to investigate whether performance is related to top-down attention.
Additionally , we investigated age differences in the association between visual attention and emotional reactivity , and whether these are moderated by cognitive reappraisal.
Additionally , we investigated genotypic variants involved in genotype-by-age interactions to understand how the genomic regulation of gene expression alters with age.
Additionally , we investigated whether these errors were benefited by phonemic cues , and similarly to SD , our AD patients had small improvement.
Additionally , we measured surrogates of global WM integrity ( fractional anisotropy , mean diffusivity , volume ) .
Additionally , we observed accumulation of gap junction Connexin43 , and diminished Connexin46 levels in vivo and in vitro.
Additionally , we observed a marked recruitment of reactive infiltrates mainly 6-24 hours after treatment and inflammatory cells included CD11c ( + ) .
Additionally , we observed shorter telomeres , mitochondrial dysfunction , and upon transforming growth factor-β stimulation , increased markers of endoplasmic reticulum stress.
Additionally , we observed that the methylation change of the sites in the low-CpG promoter region was remarkable.
Additionally , we performed re-sequencing of WNT16 on two cohorts selected from the young OAS cohort , based on their extreme BMD values.
Additionally , we performed voxel-based morphometry analyses to investigate the functional-neuroanatomic relationships between performance and voxel-based estimates of atrophy in whole-brain analyses.
Additionally , we propose a working decision algorithm for defining dynapenia.
Additionally , we provide an overview of limitations of the current research and recommendations for future research.
Additionally , we provide new experimental evidence for interactions within this network in regenerative processes in AD.
Additionally , we replicated the correlations between arterial compliance and age , eCRF , global brain atrophy , and cognitive flexibility.
Additionally , we required axial force to remain constant over the cardiac cycle.
Additionally , we show that senescence and the concomitant failure of proteostasis negatively affects stemness.
Additionally , we studied dementia with Lewy body disease ( DLB ) .
Additionally , we used diffusion tensor imaging to measure white matter integrity for both groups.
Additionally , we used our model to investigate patients who had imaging scans without evidence of dopaminergic deficit ( SWEDD ) .
Additionally , we were able to demonstrate increasing myelinopathy in aged 5xFAD mouse spinal cord using the lipid probe Nile Red with high resolution.
Additionally , we will review re-operation rates , trends in management , and future care needs.
Additionally , when mitochondria become dysfunctional , they can orchestrate the cell to undergo cell-death.
Additionally , widowhood explained stable differences in CES-D scores between twins within a family up to @number@ years after spousal loss.
Additionally , YFAS diagnosis and symptom score was higher in clinical samples compared to non-clinical counterparts.
Additional measurements included the distance from the upper eyelid margin to brow , margin reflex distance-1 , and palpebral fissure width.
Additional mechanisms are thought to underlie cyanide-induced neuronal damage , including generation of reactive oxygen species.
Additional MFU-V treatments can be considered @number@ months after the first treatment.
Additional models examined genotype-specific effects of age on the imaging markers.
Additional models showed that , when considering multiple cognitive systems , perceptual speed accounted for the most variance in decision-making in participants with MCI.
Additional models tested whether physical activity and carotenoids were conjointly related to mortality.
Additional nonpathological SH lumbo-pelvic remains are consistent with previous hypotheses , suggesting a less-pronounced sagittal spinal curvature in Neandertals compared with Homo sapiens.
Additional paradigms for testing therapeutics aimed at slowing aging are needed.
Additional parameters including urinary flow and post voiding residual volume were also collected.
Additional persons from involved organisations will participate in the study of the implementation.
Additional pharmacovigilance of the association between falls and Alzheimer's medication use is warranted.
Additional policies can improve service accessibility and overcome utilization barriers.
Additional population-based studies are required to more accurately project worldwide disease burden.
Additional predictors identified may further characterize the expected course of Parkinson's disease and suggest mechanisms underlying disease progression.
Additional prevalent pathologies include cerebrovascular disease and hippocampal sclerosis , both high-morbidity brain diseases that appear to peak in incidence later than AD chronologically.
Additional prospective validation of these results in non-US , non-white , and prospective community-based cohorts is necessary before clinical use.
Additional quantitative analysis of new collagen production was performed by means of two image analysis methods.
Additional questionnaires asked about severity and impact of their symptoms.
Additional randomized controlled trials and large prospective studies are still required to determine the relationship between passive smoking and hypertension among the Chinese elderly.
Additional randomized controlled trials are needed to confirm efficacy and safety findings.
Additional relevant studies were identified by a manual review of reference lists.
Additional research examining ALM as a therapeutic target is warranted.
Additional research , focusing on subjects with defined metabolic defects and using a range of doses , is needed to advance the field.
Additional research increasing understanding of the bidirectional relationship between hospitalizations , dementia and depression , along with targeted interventions to reduce hospitalizations , is needed.
Additional research is necessary to delineate the mechanisms behind these phenomena to inform the public about falls-prevention programs.
Additional research is needed on a larger sample since generalization of these results is limited by the small sample size.
Additional research is needed on the potential impact of antimuscarinics on cognition in vulnerable elderly persons.
Additional research is needed regarding the direct and indirect costs and benefits of volunteer support services for vulnerable older adults and their families.
Additional research is needed to better understand the epidemiology , phenomenology , and treatment of geriatric bipolar disorder.
Additional research is needed to demonstrate the link between potentially inappropriate treatment and adverse health outcomes in misdiagnosed AD patients.
Additional research is needed to determine if a more sensitive and specific index can be developed.
Additional research is needed to determine optimal nutrient doses , combinations and forms in relation to desired health outcomes.
Additional research is needed to determine what factors are responsible for the apparent underrepresentation of Hispanics in the LTCI market.
Additional research is needed to determine whether physical activity moderates long-term physical and functional limitations.
Additional research is needed to evaluate the low A1C-mortality relationship , as well as protocols for individualizing diabetes care.
Additional research is needed to identify factors that optimize responsiveness to exercise to maximize its functional benefits in older adults.
Additional research is needed to understand how to best support these at-risk emerging adults.
Additional research is needed to understand individual perceptions for engaging in future life-sustaining treatment decisions.
Additional research is needed to understand the variables associated with effective use of VR services.
Additional research is now required to further explore age-related issues contributing to poor access to palliative care.
Additional research is required to confirm our findings in other populations , and to explore potential mechanisms underlying the lipid-homocysteine interaction.
Additional research is urgently needed to address these issues.
Additional research may be needed to promote the identification and management of sarcopenia and sarcopenic obesity in the elderly population.
Additional research on contextual and psychosocial influences on health outcomes among women is needed.
Additional research on hormone dose , formulation , and route of delivery will be important for improving this model.
Additional research should clarify the mechanisms underlying this association and the role of hyperuricemia in the development of fatty liver.
Additional respective mean postnatal doses received by cohort members were @number@ and @number@ mGy.
Additional risk factors for stroke identified in WHI should be followed up to determine if reversing them would result in lower stroke rates.
Additional signatures predicting regional tumor localization and disease dissemination were also identified.
Additional sources of interest are the phenomenology of responsibility by Emmanuel Lévinas and works on absurdity and rebellion by Albert Camus.
Additional specimens were made from the repair resin composite materials to study the cohesive strength.
Additional statistics are provided by education level.
Additional strategies may be needed to sustain or augment muscle mass and strength gains achieved during short-term hormone therapy.
Additional studies addressing the influence of sex on the pathogenesis of chronic and autoimmune diseases in the aged are warranted.
Additional studies are necessary to elucidate the effects of cognitive impairment on the association between prefrontal activity and walking under various conditions.
Additional studies are needed , focusing on a well-defined frail population and with specific attention to the design and the individual contribution of mono-domain interventions.
Additional studies are needed to better understand and provide treatment for patients with this unexpectedly common cliniconeuropathologic condition.
Additional studies are needed to clarify the role of multivitamins on CVD.
Additional studies are needed to clarify whether DNA methylation age reflects biological mechanisms implicated in the aging of the cerebral white matter.
Additional studies are needed to confirm these results.
Additional studies are needed to determine whether hormonal interventions are warranted in selected men with T2D and / or the metabolic syndrome.
Additional studies are needed to develop specifically tailored exercise programs for older adults that can easily be implemented into clinical practice.
Additional studies are needed to elucidate whether reduced inflammation or other mechanisms may underlie the benefits of supplementation.
Additional studies are needed to evaluate the mechanisms that may explain this association.
Additional studies are needed to unravel the underlying mechanisms , as well as to confirm the observed gender difference.
Additional studies are needed to unravel the underlying mechanisms , as well as to confirm the observed sex difference.
Additional studies are thus needed to fill the gap in knowledge about specific tools used to assess competency.
Additional studies are warranted in order to design adapted prescriptions in antioxidant vitamins and minerals.
Additional studies are warranted to elucidate the basis of these discordant results and extend research into the potential role of pistachio bioactives promoting skin health.
Additional studies are warranted to investigate the possible role of these mutations in the pathogenesis of neurodegenerative disorders.
Additional studies conducted in vitro and in animal models suggested anti-inflammatory properties.
Additional studies examining a broad range of comorbidity are required , along with clear and consistent indexing to allow for improved synthesis of the evidence.
Additional studies of bone health among aging female cancer survivors may be warranted.
Additional studies using accelerometers in large , diverse cohorts of older women are needed to confirm and extend these findings.
Additional studies with objective sleep measures are needed to determine whether sleep disturbance causes or accelerates Alzheimer disease.
Additional support for distinct variation in IL-6 biology was generated when systemic levels of the soluble receptor for IL-6 ( sIL-6r ) were evaluated.
Additional treatments and procedures are often implemented to care for the aging adults with comorbidities.
Additional treatments , such as oxidative stress , show no effect.
Additional variables , which may affect the CAR , were assessed by questionnaire.
Additional VHL functions have been reported , including induction of senescence upon loss of VHL mediated by downregulation of the chromatin remodeling factor p400.
Additional work is needed to address polypharmacy and to determine if medication regimen complexity influences adherence and clinical outcomes in this population.
Additional work is needed to clarify the mechanisms of these findings.
Additional work is needed to elucidate the mechanisms underlying this interaction.
Additional work is warranted given the population health implications associated with long-term low-level arsenic exposure.
Additional work is warranted to investigate the complex relationship between 25 ( OH ) D and colorectal cancer risk.
Addition missing vitamin or vitamins restores the performance of antioxidant system.
Addition of 24-hour SBP to the ARV models only slightly improved variance explained by the models ( R2 = @number@ and @number@ respectively ) .
Addition of ApoE genotype to the model improved performance , i.e. , AUC of @number@ miRNA plus ApoE4 improves to @number@
Addition of ascorbic acid without sulfites should be avoided by brewers , as the former would intensify sotolon synthesis.
Addition of Aβ peptide to the culture medium resulted in an increase in 4-HNE levels in SH-SY5Y cells.
Addition of BIRB796 , an inhibitor of p38 activity , to IFN-α-treated cells reversed , in part , the inhibition of telomerase by this cytokine.
Addition of circadian interventions can ameliorate the negative effects of inappropriately timed sleep as well.
Addition of elevated HbA1c to the model with IFG resulted in improved discrimination and calibration.
Addition of exogenous PGRN or conditioned medium from control cells normalized the response of PGRN-deficient lymphoblasts to serum activation.
Addition of folate did not change any of the results.
Addition of HDL selectively increased the efflux of 7KFAEs and enhanced the effect of SOAT1 overexpression.
Addition of health variables seldom increases variance accounted for in each domain beyond these four dimensions.
Addition of leucine did not modify the insulin , WbPB , WbPS or MPB response.
Addition of organic carbon significantly lowered bioavailability for all compounds except for @number@'-DDT.
Addition of @percent@ of the daily dose did not affect liking.
Addition of recombinant human CCN1 to skin equivalent cultures significantly reduced type I procollagen and increased MMP-1.
Addition of the pan-caspase inhibitor ZVAD-FMK partly reversed the cisplatin-induced cell death.
Addition of these criteria should modulate time intervals for patient follow-up examinations.
Additive and multiplicative linear regression models are used to analyze logged C-reactive protein levels ( mg / l ) drawn from assayed blood samples.
Additive genetic influences on DHEAS concentrations were consistent between at-home and DOT measures.
Additive interaction between burden of GS and CMD was assessed using logistic regression models.
Additive Medicare expenditures associated with sentinel injury over @number@ years were estimated at $ 28 , 885.
Additive tissue engineering replaces cells or tissue , or tries to get something to grow that is no longer there.
AddNeuroMed , ADNI , and AIBL differed from the population-based cohorts in several demographic-clinical variables that had a significant effect on hippocampal volume.
AD does not just come suddenly out of nowhere.
Addressing any underlying conditions that contribute to nocturia is the first step in treating the condition.
Addressing focal neuronal losses in temporal lobes may represent an important strategy to prevent gait instability.
Addressing geriatric syndromes and avoiding hypoglycemia should be given as high a priority as preventing diabetes complications in older adults with diabetes.
Addressing issues around discrimination in older adults may contribute to maintaining functioning in later life.
Addressing more than one component of vision may be needed to reduce the effect of vision impairment on functional decline.
Addressing participant concerns can facilitate inclusion and enhance HIV research success.
Addressing similarities rather than differences improves their chances for collaboration.The number of adult children providing household care to older parents increased between @number@ and @number@
Addressing social integration and mobility out of the home is an important element of rehabilitation for older people with stroke as well as those without.
Addressing the need for involvement in these networks by older adults might help delay functional decline and save on healthcare costs.
Addressing the potential for overdose with barbiturates may aid suicide prevention in the elderly.
Addressing these barriers to adoption is therefore vital.
Addressing these challenges requires the development of high-throughput aging and longevity assays.
Addressing these complex needs will allow the VA to provide enhanced care to older homeless veterans.
Addressing these gaps will facilitate development of the mechanism-based strategies needed for designing more effective HRT regimens.
Addressing these issues and the influence of oral health on food intake are imperative to enhancing the overall quality of life for older adults.
Addressing these issues may improve outcomes in the aging HIV-positive population.
Addressing these questions highlights key areas of feasibility that must be considered in this area of research.
Addressing these unique participant burdens can ensure successful study participant recruitment and retention in ongoing and future longitudinal studies on aging.
Addressing this workforce deficiency requires improvements in the geriatric training pipeline , reimbursements , and practice environments.
A DDR-resistant MYOD mutant could overcome this barrier by resuming cell cycle progression.
A DDT and dieldrin contaminated soil was amended with four organic carbon materials to assess the change in bioavailability.
Adduced proofs of the telomere shortening are the main or even the sole mechanism of the natural and radiation aging.
A decade-on-decade increase in frequency was found with a peak of @percent@ among patients older than @number@ years.
A deception was used to ensure that the perturbation was truly unexpected.
A decision tree model was constructed and populated with probabilities , outcomes and cost data from published sources , including one-way and probabilistic sensitivity analyses.
A decline in attention explained some , but not all , group differences in memory performance.
A decline in CD34 + CPCs was reported with advancing age.
A decline in cerebrovascular angiogenesis may inhibit recovery from hypoxia-induced capillary loss.
A decline in cerebrovascular reserve capacity and emerging degenerative vascular wall changes underlie complete and incomplete brain infarcts , haemorrhages and white matter hyperintensities.
A decline in higher-level functional capacity was defined as a ≥2-point decrease in the TMIG-IC score after @number@ years.
A decline in mitochondrial activity has been associated with aging and is a hallmark of many neurological diseases.
A decline in mitochondrial function plays a key role in the aging process and increases the incidence of age-related disorders.
A decline in NA during aging is well documented but its impact on memory function during aging is unclear.
A decline in navigational abilities is a consistent feature of aging.
A decline in proteasome function is causally connected to neuronal aging and aging-associated neuropathologies.
A decline in sex steroids and glucocorticoid and alcohol use , among other factors , contribute to bone loss and fracture risk.
A decline in skeletal muscle mass and function with aging is well recognized , but remains poorly characterized at the molecular level.
A decline in the mitochondrial functions and aging are two closely related processes.
A decline in the replicative and regenerative capacity of adult stem cell populations is a major contributor to the aging process.
A decline with age of @percent@ per decade was found only in striatum.
A declining sexual dimorphism was also apparent.
A decreased sensory feedback from the oropharyngeal mucosa leads to a delayed triggering of the swallowing reflex.
A decreased walking speed was not associated with falls.
A decreased zinc status in aged mice was similarly associated with increased ICAM1 and IL6 gene expression.
A decrease in ataxin-2 suppresses TDP-43 toxicity in yeast and flies , and intermediate-length polyglutamine expansions in the ataxin-2 gene increase risk of ALS.
A decrease in cell proliferation was observed during the progression of senescence.
A decrease in genomic methylation commonly occurs in aging cells ; however , whether this epigenetic modification leads to age-related phenotypes has not been evaluated.
A decrease in health conditions was the most vulnerable subgroup's ( steeply-increasing ) primary risk factor.
A decrease in the amount of produced saliva due to aging and parotiditis results in a dry mouth.
A decrease in the CSF concentration of Aβ40 and Aβ42 is a potential biomarker for incident AD.
A decrease in the expression of activating receptors ( NKp30 and NKp46 ) was observed in NK cells in elderly individuals.
A decrease of ≥0.1 m / s in gait speed was considered clinically relevant.
A decreasing trend of proportion of left-handed males was found in relation to aging.
A deeper understanding of the conserved molecular mechanisms in different taxa have been made possible only because of the evolutionary conservation of crucial signaling pathways.
A deeper understanding of the mechanisms regulating the viability of senescent cells is therefore required.
A deeper understanding of the mechanistic underpinnings of Sirt1's metabolic functions is necessary to effectively design Sirt1-based therapeutic interventions for metabolic disorders.
A deeper understanding of these processes is required before these findings can be translated into human anti-aging and anti-cancer therapies.
A defesa de um sistema democrático e sustentável evidencia a importância de entender como são estabelecidos os processos relacionados às mudanças na saúde.
A defining characteristic of diverse stem cell populations is their distinct metabolic state , although how these states change during adult hippocampal neurogenesis is unclear.
A definition for a single risk factor such as dynapenia will provide information in building a risk profile for the complex etiology of physical disability.
A definition of HMPs or what was considered an HMP was frequently missing.
A definition of low appendicular lean mass with slowness or weakness was based on the consensus of the Asian Working Group for Sarcopenia.
A degenerative meniscal lesion often suggests early-stage knee OA.
A delirium diagnosis , pain , and diabetes were independently associated with prevalent depression.
A demethylating agent restored the normal epigenetic status of the TIF1G promoter in human cells , which correlated with a reestablishment of TIF1γ expression.
A demographic data form was completed.
A dendrimer-resveratrol complex was prepared , optimized and tested for solubility enhancement , stability in solution and cream dosage forms.
Adenine and N Historically , the medical subspecialties have not focused on the needs of older adults.
Adeno-associated virus ( AAV ) is the most promising gene delivery vehicle.
Adenohypophyseal and psoas major tissue sections were immunohistochemically processed and stained by anti-human growth hormone and anti-fast myosin antibodies , respectively.
Adenosine and inosine inhibited platelet aggregation and ATP release stimulated by ADP and collagen.
Adenosine and inosine reduced collagen-induced platelet adhesion and aggregate formation under flow.
Adenosine @number@'-monophosphate ( ATP ) was measured by a variety of methods.
Adenosine-to-inosine ( A-to-I ) substitutions are the most common type of RNA editing in mammals.
Adenoviral-mediated Sirt1 overexpression prevented prion protein ( PrP ) ( 106-126 ) -induced neurotoxicity via autophagy processing.
Adenovirus-mediated gene transfer was used to overexpress caveolin specifically in the liver of diabetic obese mice , which were generated with a high-fat diet.
Adenovirus types @number@ @number@ and @number@ may cause epidemic keratoconjunctivitis.
Adenovirus was the most common agent ( @percent@ ) .
A depressive component was present in @number@ patients ( @percent@ ) .
Adequate dietary calcium intake may be particularly important for tea and coffee drinkers.
Adequate DNA analysis was performed in @number@ men and women ( ≥65 years ) .
Adequate evaluations and diagnoses are , therefore , essential for successful management.
Adequate hand hygiene compliance by healthcare staff is considered an effective method to reduce hospital-acquired infections.
Adequate health services should be ensured for older adults with hearing difficulties.
Adequate intakes of a number of nutrients are recognized to be problematic in traditional complementary feeding regimens in developing societies.
Adequate muscle mass and strength are necessary in combat or evacuation situations , which prompt for improved understanding of muscle mass modulation during SSR missions.
Adequate muscle perfusion is required for the maintenance of skeletal muscle mass.
Adequate nutrition for older persons has vital influence on maintaining good health and social functioning.
Adequate nutrition is critical to child development and institutions such as day-care centers could potentially complement children's diets to achieve optimal daily intakes.
Adequate photoprotection is essential to control photocarcinogenesis and photoaging.
Adequate protein and energy intakes and physical activity ( PA ) may preserve MS during aging.
Adequate protein and thiamine intake is more likely associated with achieving a good overall nutritional status which affects cognitive function rather than single nutrients.
Adequate symptom control after surgery was achieved in almost @percent@ of patients.
A derivative of this observation is the hypothesis that a convergent pathophysiological substrate subserving MDD and DM may promote beta amyloid ( Aβ ) deposition.
A description of critical assumptions which underlie some of these approaches is emphasized.
A description of the first @number@ months of enrollment in this longitudinal register will be provided.
A description of the model is presented , and early implementation experiences during the first year of the project are reported.
A descriptive analysis was performed to establish a health profile by socio-demographic characteristics.
A descriptive analysis was used for data extraction and charting.
A descriptive cross-sectional study was conducted in Teaching Hospital-Kurunegala during @number@ to @number@
A desire to change can be encouraged through expression , listening and analysing current behaviour.
A detailed appraisal of therapeutic options is provided with special emphasis on 5-aminosalicylate , probiotics , mesalamine , percutaneous abscess drainage , and image-guided embolization.
A detailed consent form needs to be completed by the patient.
A detailed description is provided about the recruitment and organization and the selected instruments.
A detailed examination of these shadows will lead to an understanding of how to apply volumetric techniques to create natural appearing results.
A detailed knowledge of all the factors , which may influence VEP is essential for its correct interpretation.
A detailed medical examination is recommended ( including an unspecific bronchial provocation test ) before starting to dive.
A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography ( SD-OCT ) with enhanced depth imaging for measurement of SFCT.
A detailed ophthalmic examination was performed , including spectral-domain optical coherence tomography with enhanced depth imaging for CT measurement.
A detailed photo and thermal stability studies were performed to examine the stability of AA in the proposed nanocomposite.
A detailed post-hoc analysis is also presented.
A detailed questionnaire was completed , and comprehensive geriatric assessment and blood analyses were performed.
A detailed understanding of the device being used is recommended.
A detailed understanding of the device being used is recommended.
A deterioration in bone microarchitecture and an inefficient distribution of bone mass with insufficiency of repair and adaptation mechanisms appear to be factors of relevance.
A developmental account for the perceptual-motor mechanisms of prevalence effect is discussed.
ADF is a novel and unique experimental model of diet-induced diastolic dysfunction.
AD has an important genderdependent component and is benefitted by lifestyle strategies such as physical exercise , enriched environments and nutrition.
ADHD children were not classified convincingly with these markers.
ADHD diagnosis and level of ADHD symptoms were assessed.
ADHD symptoms and diagnosis were assessed with the Diagnostic Interview for ADHD in Adults ( DIVA ) @number@
ADHD topics are dependent upon diagnostic site , suggesting diagnostic differences across geographic locations.
Adherence according to pill count was excellent ( spironolactone @percent@ , placebo @percent@ ) .
Adherence and biofilm in vitro formation was strongly affected by pre-treatment with pexiganan and imipenem , with the latter being the more effective antibiotic.
Adherence improved with each subsequent visit for continued patients , @percent@ at the second visit to @percent@ at the last.
Adherence is monitored using a doubly labeled water technique.
Adherence predicted cognitive performance ( p = @number@ ) .
Adherence to a Mediterranean-like diet was assessed according to a modified Mediterranean Diet Score derived from 7-day food records.
Adherence to appropriate maintenance drug regimens has been reported to reduce hospitalization and health care spending in clinical trials.
Adherence to a priori dietary patterns , namely the Mediterranean Diet Score ( MDS ) was assessed.
Adherence to infection control standards during CIED insertion would reduce infection from B. cepacia.
Adherence to medication schedules and possible future alternative drug delivery systems will also be presented.
Adherence to MeDi was evaluated by an a priori score ( range 0-55 ) , derived from a detailed food frequency questionnaire.
Adherence to @number@ process-based quality indicators ( QIs ) was measured , and a pass rate was calculated for each individual QI.
Adherence to @number@ process indicators was evaluated , comparing also stroke units ( SU ) with conventional wards.
Adherence to protocols was tracked daily.
Adherence to the DASH score was not associated with change in cognitive function over @number@ years.
Adherence to the exercise plan was evaluated using performance data collected by the app and through information given by the participants during the study.
Adherence to the five selected performance measures significantly improved.
Adherence to the internationally recognized guidelines for early infant feeding should be an intervention priority for this population.
Adherence to the LGIMD as measured by Mediterranean Adequacy Index ( MAI ) showed a median of @number@
Adherence to the MedDiet was also significantly associated with better cognitive performance and less cognitive decline.
Adherence to the Mediterranean dietary pattern was determined using the Mediterranean Diet Adherence Screener ( MEDAS ) .
Adherence to the Mediterranean diet was assessed at baseline by the standard 10-unit Mediterranean diet score ( MDS ) .
Adherence to the MeDi was evaluated by the Mediterranean dietary score ( MedDietScore ) .
Adherence to the training protocol was high ( @percent@ ) .
Adherence was assessed as training days accomplished relative to the target of @number@ days / wk over @number@ mo.
Adherence was assessed by login frequency , duration and activity level ; analyses examined demographic , medical and psychological predictors of uptake and adherence.
Adherence was higher in STRICT than AUT during the intervention ( p = 0.001 ) , but not during follow-up.
Adherence was predicted by older age and control-group allocation.
Adherent invasive E. coli ( AIEC ) colonize ileal mucosa of CD patients and strongly promote gastrointestinal inflammatory disorders by activation of HIF-dependent responses.
AD heritability was enriched within the PU.1 cistrome , implicating a myeloid PU.1 target gene network in AD.
Adhesion studies on zirconia and reporting of data require more standardization.
Adhesive bonding of the treated groups was preceded by a 1min application of an experimental EDC conditioner to the acid-etched dentin.
Adhesive capsulitis is , in most cases , a self-limiting condition of poorly understood etiology that results in shoulder pain and large mobility deficits.
Adhesive factors like BabA , SabA and ureaseA are necessary for adhesion against MHC-II complexes and Le antigens.
Adhesive Remnant Index ( ARI ) was also identified.
Adhesive treatments could be applied to luting the restorations and fabricating hybrid-structured FDPs.
A diabetes-age interaction was discovered : as age increased , the association of diabetes with new geriatric conditions decreased.
A diagnosis of ALS was established.
A diagnosis of delirium and uncorrected visual impairment at follow-up occurred concurrently with incident depression.
A diagnosis of dementia has life-changing implications for an individual of working age.
A diagnosis of ESRD and CKD were both found to significantly increase hospital mortality , length of stay and cost.
A diagnosis of white fibrous papulosis of the neck was made , which is believed to be a manifestation of intrinsic aging.
A diagnostic approach was undertaken to include demographics , clinical features and laboratory investigations of the study subjects.
A diagnostic interview to diagnose ADHD was administered among a subsample ( N = @number@ age 60-94 ) .
A diagnostic interview to diagnose ADHD was administered among a subsample ( N = @number@ age 60-94 years ) .
A diary was used to determine the nocturia index , nocturnal polyuria index , index of nocturnal bladder capacity.
A dietary pattern characterized by higher vegetable and fruit intake was associated with a better skin condition.
A diet rich in compounds such as genistein , SFN and EGCG can positively modulate the epigenome and lead to many health benefits.
A difference between children in private and public kindergartens also emerged.
A difference between patients and controls in P300 latency was evident with ageing , with latency increasing faster in patients.
A difference in mtDNA damage between these two populations was also detected , indicating the role of ancestry as a component.
A difference in the region-specific muscle thickness was observed between the young and elderly.
A different approach that has several clinical advantages is to place the laryngeal mask airway prior to the IV.
A different gender dimorphism in volume was found depending on the normalization method used for both simulated and real data.
A differential assessment of dementia , its presenting neuropsychiatric symptoms and the potential presence of pain is crucial to provide the correct treatment.
A differentiation in the distribution of the frequencies with increasing age may provide new insights into the age-dependence of taste quality brain centers.
A different magnitude of p53 binding protein @number@ ( 53BP1 ) recruitment contributed to diverse capsaicin-induced genotoxic effects in DU145 and A549 cells.
AD in particular is accompanied by widespread cortical neuronal loss , and loss of connections between brain systems.
Adipo and Tcad proteins were colocalized in aorta , heart , and skeletal muscle.
Adipocyte differentiation was inhibited in Slc25a24-KO adipose tissues and Slc25a24-knockdown adipocytes.
Adipocytes in the basal state sequestered free fatty acids , thereby forcing neighboring myotubes to rely more heavily on glucose fuel.
Adipocytes were used to verify the effects of nebivolol onlipolysis , uncoupling protein @number@ ( UCP1 ) and other genes of the thermogenic program.
Adipocytokines released from adipose tissue are thought to modulate some brain functions including memory and cognition.
Adipogenesis and lipid accumulation during aging have a great impact on the aging process and the pathogenesis of chronic , age-related diseases.
Adipogenic and osteogenic differentiation was also decreased at higher passages.
Adipokines and their respective signalling pathways have drawn much research attention in the field of oncology and cancer therapeutics.
Adiponectin ( Adipo ) , a multimeric adipocyte-secreted protein abundant in the circulation , is implicated in cardiovascular protective functions.
Adiponectin , an adipocyte-derived protein , exerts anti-atherosclerotic effects on the vascular endothelium.
Adiponectin and insulin signaling pathways converge at the adaptor protein APPL1.
Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models.
Adiponectin and VFA were significant predictors of PTX-3 levels.
Adiponectin exerts its effects by binding to adiponectin receptors , two of which , AdipoR1 and AdipoR2 , have been cloned.
Adiponectin exerts multiple protective effects against cardiovascular disease , independent of its insulin-sensitizing activity.
Adiponectin , interleukin-6 ( IL6 ) and C-reactive protein ( CRP ) were available in a subgroup of patients ( n = 32 ) .
Adiponectin is a hormone that is derived from adipose tissue and is reduced in obesity-linked diseases including insulin resistance / type @number@ diabetes and atherosclerosis.
Adiponectin is an adipocyte-specific adipokine involved in systemic metabolism.
Adiponectin is an insulin-sensitizing adipokine with protective effects against a cluster of obesity-related metabolic and cardiovascular disorders.
Adiponectin levels , estimated creatinine clearance rate and obesity indices were determined.
Adiponectin , nitric oxide synthase and sirtuin may form a network of cardiovascular protection during caloric restriction.
Adiponectin was assayed using a sandwich ELISA system.
Adiponectin was neither related to BMI nor to any metabolite.
Adipo positively regulated levels of Tcad protein in vivo and in endothelial cell ( EC ) cultures.
AdipoR1 and AdipoR2 mRNAs were also expressed in keratinocytes , though neither fAd nor gAd had any effect on HA synthesis.
Adipose-derived mesenchymal stem cells ( AdMSCs ) have been reported to have therapeutic benefit in skin.
Adipose-derived stem cells ( ADSC ) have relative advantages in accessibility and abundance compared to other kinds of stem cells.
Adipose-derived stem cells ( ADSCs ) are known to secrete various cytokines , which affect fibroblast function through paracrine effects.
Adipose tissue area and density in Hounsfield units were measured in the thigh and abdomen by using computed tomography.
Adipose tissue-derived stem cells ( ADSC ) are promising candidates for therapeutic applications in cardiovascular regenerative medicine.
Adipose tissue historically was believed to be an inert tissue , functioning primarily in the storage of energy and thermal homeostasis.
Adipose tissue is a hormonally active tissue that produces adipokines that influence the activity of other tissues.
Adipose tissue is an endocrine and paracrine organ that contributes to both metabolic and vascular homeostasis.
Adipose tissue is an important source of hormones having influences on both metabolism and reproduction.
Adipose tissue is a pivotal organ determining longevity , due largely to its role in maintaining whole-body energy homeostasis and insulin sensitivity.
Adipose tissue is composed of lipid-filled mature adipocytes and a heterogeneous stromal vascular fraction ( SVF ) population of cells.
Adipose tissue is not a homogeneous organ.
Adipose tissue plasticity mediated by inflammation is an important evolutionary achievement to survive seasonal climate changes.
Adipose tissue T cell recruitment to adipose tissue is also different between aging- and diet-induced obesity.
Adiposity also influences sarcopenia ( β : @number@ ) .
Adiposity assessment included body mass index , waist circumference , and fat mass index.
Adiposity-by-age interactions were examined.
A direct cause-consequence relationship has been established between mtDNA mutations and aging phenotypes in mammals.
A direct comparison that assesses forensic parameters and applicability to casework between the two kits has never been carried out.
A direct significant correlation between blood pressure level and a total score of MMSE was revealed in senile patients.
AD is also associated with visual disturbances , but their causes remain unidentified.
AD is a neurodegenerative disorder targeting different brain areas and types of neurons.
AD is a serious disease that has both societal and economic impacts.
AD is associated with elevated levels of oxidative damage in brain and peripheral lymphocytes.
AD is characterized by early cognitive deficits , particularly in short-term memory , followed by a gradual decline in other cognitive functions.
AD is characterized by pathological aggregation of two proteins , tau and Aβ-amyloid.
AD is characterized by the accumulation of amyloid β-peptide ( Aβ ) in the brain and the loss of cholinergic neurons in the basal forebrain.
AD is characterized by the extracellular amyloid beta ( Aβ ) plaques and intraneuronal deposits of neurofibrillary tangles ( NFTs ) .
A disconnect in education , communication , and information between HCPs and their menopausal patients remains prevalent.
A discontinuity in the rate of increase in fluorine content with age was observed in women at around age @number@
A discrepancy in perceived filial piety between generations also emerged.
A discriminant function analysis is used to discriminate among different genders and age groups.
A discussion of how musical participation may enhance cognitive aging is provided along with other alternative explanations.
A discussion of the model parameter space in terms of traditional time delay embedding provides a theoretical basis for our multiscale approach.
A discussion of various surgical approaches with their advantages and disadvantages is presented , and the importance of maintaining a safe lower eyelid is emphasized.
A discussion of why this may have happened ensues.
AD is defined by specific neuropathology : neuritic amyloid plaques and neocortical neurofibrillary tangles.
A disease influences and is influenced by the nutritional status and the functional capacity of the individual.
A disease modifying therapy that slows or stops disease progression is therefore a major unmet medical need.
AD is mainly characterized neuropathologically by the presence of two kinds of protein aggregates : extracellular plaques of Abeta-peptide and intracellular neurofibrillary tangles.
AD is not a singular , homogeneous disease , but rather a final common pathway or end-point that can be arrived at through multiple routes.
AD is perceived to be a disease primarily of the mind , but in comparison to differences expected with aging , physical prowess is enhanced.
A dispersion model in one dimension has been used to describe the non-ideal behavior of the reactor.
A ' distal-dorsal difference ' ( DDD ) at baseline , and the recovery rate of the second fingertip and dorsum were calculated.
AD is the most common cause of dementia worldwide , and its incidence is increasing in line with population aging.
Aditional research and further experimental testing will help to identify new targets and help to make this journey successful.
A diverse T cell receptor ( TCR ) repertoire is essential for controlling viral infections.
Adjacent categories logit regression analysis with backward elimination was used to determine variables associated with three groups based on the number of lacunar infarctions.
Adjacent stromal reaction in particular showed a marked increase from red through brown and black to white lesions.
Adjacent structures correlated with the cochlear position.
Adjudicated final diagnosis of infection was done by two experts including patient history , clinical and laboratory findings as well as radiographic studies.
Adjudicated incident dementia cases were diagnosed according to international guidelines.
Adjunctive antifungal therapy is beneficial for asthma control.
Adjunctive cardiovascular medicines were significantly less likely to be dispensed to those with established heart conditions and non-related co-morbidities , particularly dementia.
Adjusted analysis revealed that individuals with high occupational cognitive demands were more likely to have prevalent MC.
Adjusted and unadjusted coefficients were virtually identical.
Adjusted associations of treatment assignment with these outcomes were estimated using generalized least squares regressions with random provider effects.
Adjusted cohort-specific hazard ratios were derived by using Cox proportional hazards regression and subsequently pooled using random-effects meta-analysis.
Adjusted , cohort-specific HRs were pooled using random-effects meta-analysis.
Adjusted comparisons were made on samples ( N = 16 , 859 each ) using propensity score matching.
Adjusted COX proportional survival analysis was conducted.
Adjusted CS score was lower in HIV-infected participants compared to HIV-seronegative individuals ( @number@ vs. @number@ p = @number@ ) .
Adjusted cubic splines showed a positive and linear association between adiponectin and incident AF.
Adjusted differences in %5-methylated cytosines ( %5 mC ) were examined by categories of predictors using multivariable linear regression models.
Adjusted for age , gender , and education , the HR ( @percent@ CI ) was @number@ ( @number@
Adjusted for these determinants , depressed patients had significantly higher NGAL plasma levels compared to non-depressed comparison group.
Adjusted general estimating equations were used to investigate whether EC families had a better longevity and age-related biomarker profiles than non-EC families.
Adjusted grip strength change per year was similar for each group of ACE inhibitor use ( P > @number@ ) .
Adjusted hazard ratios ( ARHs ) of short-term suicide after hospital discharge were also estimated by Cox proportional hazards regression models.
Adjusted hazard ratios ( HRs ) were computed using Cox proportional hazard regression.
Adjusted least squares means of oxytocin were calculated.
Adjusted models included variables assessing personal advantage and disadvantage , place-based factors , sociodemographics , comorbidities , and health behaviors.
Adjusted odds of treatment were higher for younger residents , whites , and those with moderate impairment of cognitive function.
Adjusted odds ratios and @percent@ confidence intervals ( [ , ] ) for FP conversion were estimated using logistic regression models with generalized estimating equations.
Adjusted odds ratios for the main confounders were obtained using logistic regression.
Adjusted odds ratios of having each specific disorder were calculated for foot posture and function subgroups relative to a referent @number@ quintiles.
Adjusted odds ratios ( ORs ) and @percent@ confidence intervals ( CIs ) for EM were estimated using logistic regression.
Adjusted PK mRNA was significantly increased in the frontal cortex in AD , and the frontal and temporal cortex in VaD.
Adjusted prevalence proportion ratios ( PR ) and @percent@ confidence intervals ( @percent@ CI ) were modelled using mixed negative binomial regression with robust variance.
Adjusted relative risk ratios ( aRRR ) for associations of parental clinical outcome with offspring allergic disease were estimated with multinomial logistic regressions.
Adjusted relative risks and @percent@ CIs were calculated using modified Poisson regression , weighted to account for selection into the autopsy cohort.
Adjusted relative risks reported for similar follow-up durations were pooled across studies separately using random-effects inverse variance models.
Adjusted risk differences and risk ratios were estimated.
Adjusted seemingly unrelated biprobit models were used to account for unobserved heterogeneity associated with the use of services.
Adjusted sensitivity was lower than reported sensitivity in @number@ ( @percent@ ) evaluations of different markers.
Adjusting for admixture from three parent populations , the average inbreeding coefficient was found to be @number@ ( ±0.019 ) or close to third-cousin mating.
Adjusting for APOE4 yielded significance for high HDL-C and CCS ( β = @number@ p = @number@ ) .
Adjusting for confounders did not significantly change these estimates.
Adjusting for confounders , no direct association was found between visual and cognitive function.
Adjusting for covariates , the PCC group was more likely than the non-PCC group to receive @number@ types of preventive services.
Adjusting for elevated brain Aβ did not attenuate any association.
Adjusting for energy intake explained < 7% of variance and did not affect the variance ratio.
Adjusting for holoTC attenuated the tHcy-AD link ( OR changed from @number@ to @number@ @percent@ CI @number@.96-1.25 ) .
Adjusting for multiple covariates , PAO burden was independently associated with the presence of hypertension.
Adjusting for nerve conduction velocity and neuropathy score decreased the effect of diabetes on SPPB by @percent@ , suggesting partial mediation through decreased PNF.
Adjusting for physical activity and weight had little effect generally.
Adjusting for school education attenuated the association only to a minor degree.
Adjusting for vascular factors slightly attenuated the associations.
Adjustment covariates were race , enrollment wave , baseline age , physical activity , and heavy alcohol use.
Adjustment for age , disease severity or presence of erythrocytes or blood pigments in CSF did not alter these results.
Adjustment for a number of covariates did not alter the association.
Adjustment for BMI attenuated the observed associations.
Adjustment for cardiovascular risk factors and 25-hydroxyvitamin D levels did not affect this HR.
Adjustment for confounding variables had no impact on the observed associations.
Adjustment for covariates , however , showed that normal ageing-related declines in kidney function and cardiac diastolic function are not independently linked.
Adjustment for demographic and socio-economic characteristics did not change the overall patterns.
Adjustment for diabetes-related complications and neighborhood deprivation index did not change the results.
Adjustment for gestational age in the replication set had no influence on the results.
Adjustment for health and lifestyle variables did not reduce the associations.
Adjustment for health behaviors and medical conditions did not attenuate this association.
Adjustment for inflammatory and blood coagulation markers did not modify our results.
Adjustment for other objectively measured markers of lifestyle measured during the clinic visit accounted for only a small proportion ( @percent@ ) of the difference.
Adjustment for parental socio-demographic characteristics ( education , occupation , family size , household crowding , language ) weakened the associations only slightly.
Adjustment for physical activity and other covariates did not materially change the results.
Adjustment for potential confounders did not change these results.
Adjustment for potential confounders was done.
Adjustment for potential confounding variables included age , gender , conventional risk factors , and B-type natriuretic peptide ( BNP ) .
Adjustment for serum osteocalcin , physical activity , and serum PTH did not alter the seasonal means.
Adjustment for skeletal growth was performed for pediatric patients.
Adjustment for sociodemographics , diabetes-related complications , and markers of clinical control did not explain observed differences.
Adjustment for the potential mediators in adulthood attenuates these associations only to a modest degree.
Adjustment for these cardiovascular comorbidities did not explain the decreased dementia incidence rates for more recent birth cohorts.
Adjustment for various confounders did not alter the association.
Adjustment models included age , body composition , C-reactive protein and lifestyle factors.
Adjustment of sensitivity to the stage distribution expected in the screening setting is crucial to obtain realistic and comparable estimates of sensitivities.
Adjustment of VO ( 2p ) and Delta [ HHb ] were modeled using a mono-exponential equation by non-linear regression.
Adjustments of functional goals ( lines of defense [ LoDs ] ) were examined during rehabilitation from incontinence.
Adjustments of therapy to reach a target pressure involve monotherapy , combination therapy and laser.
Adjustments were made for age and gender.
Adjustments were made for age of onset being less than the age of sampling , and for the observed dependence between these two ages.
Adjustments were made for age , sex and cardiovascular risk factors.
Adjustments were made for physiological and behavioral factors.
Adjustment variables included sociodemographic characteristics , health status , and use of health care services and medications.
Adjuvant arthritis was developed in male rats by administering Mycobacterium butyricum through tail base injection.
Adjuvant chemotherapy after surgery is also effective when therapeutic doses can be given in a timely fashion.
Adjuvant radiation is generally considered if the projected lifespan is > 5 years.
ADL and IADL scores in older adults with ID are comparable to those of vulnerable patient groups.
ADL class was not associated with secondary outcomes.
AD + Lewy pathology and other dementias decreased significantly over age @number@
ADL was measured at a baseline and follow-up assessment , using Sonn and Åsberg's revised scale and the ADL staircase.
ADL were predominantly affected by premenstrual symptom severity.
ADMA competitively inhibits NO elaboration by displacing L-arginine from NO synthase.
ADMA plays a role in endothelial dysfunction and increasing arterial stiffness.
ADMA remained a significant determinant of LVMI on multivariate analysis.
ADMAvalues were higher in frail subjects than in non-frail ones.
AD mice and non-transgenic ( NT ) mice received an experimental TBI on the right parietal cortex using the controlled cortical impact model.
Administering exogenous T , known as T-replacement therapy ( TRT ) , reverses many of the symptoms of low T levels.
Administration of ActRIIB.Fc was associated with greater gains in body weight ( P = @number@ ) and upper arm circumference than placebo.
Administration of ActRIIB.Fc was associated with higher muscle expression of myostatin than placebo.
Administration of ARE significantly reversed the D-galactose-induced oxidative stress by increasing the activity of the antioxidant enzymes and upregulating their gene expression.
Administration of either sirtinol or EX-527 in mice led to a reduction in both platelet count and the number of reticulated platelets.
Administration of GN to HFD-induced obese mice decreased HFD-induced liver weight , hepatic TG accumulation , and cytoplasmic lipid droplet.
Administration of low dosed Solifenacin is sufficient for significant decrease in risk of developing symptoms of overactive bladder.
Administration of monocyte-depleted HUCB cells did not suppress Iba1 labeling of microglia in the infarcted area relative to treatment with the whole HUCB preparation.
Administration of such Aβ oligomers yielded signs of the disease , including cell culture age-dependent binding of Aβ and cell death in the glutamatergic populations.
Administration of ursolic acid attenuated trauma-hemorrhagic shock-induced hepatic and lung injuries in rats.
Administration procedures have been standardized and cutoff scores are well validated in large Alzheimer's disease and mild cognitive impaired series.
Administration with betaine significantly decreased the incidence of tumor formation with downregulation of inflammation.
Administrative- and faculty-level recommendations to sustain and expand GNEC are highlighted.
Administrative data were further linked to survey-derived data of facility organizational characteristics for exploratory analysis.
Administrative data were obtained from three geographical areas of England , and we estimated transition probabilities in each of these sites flexibly using Bayesian methods.
Administrative records were used to ascertain diagnoses of geriatric syndromes , diabetes complications , and hypoglycemia.
Administrators have a role to play in giving nurses voice in workplace committees and in forums.
Admission characteristics were mostly similar between age groups.
Admission diagnosis , APACHE II and SAPS II scores , use of ICU resources , and mortality were recorded.
Admission due to associated diseases or life events was the main reason for hospitalization ( @percent@ ) .
Admission FI-lab was calculated using @number@ variables collected within @number@ hours of presentation.
Admission pathology , co-morbidities , delay to surgery , length of stay , discharge destination , functional outcome and mortality were assessed.
Admission prognostic indicators and outcomes at follow-up were compared between younger ( < 85 ) and older ( ≥85 ) age groups.
Admission risk factors that were compared in fallers and non-fallers included altered consciousness , cognitive performance , attention , sensory deficits , and dehydration.
Admissions will be checked using official discharge data of the Abruzzo Region.
Admittedly , treatment prospects for chronic , entrenched syndromes are limited , but there are these types of exceptions.
ADNI-3 , which began on @date@ , is a 5-year renewal of the current ADNI-2 study.
ADNI composite memory and executive scores were the primary outcomes.
ADNP was defined as moderate to frequent neuritic plaques and Braak stageIII-VI.
AD , obesity , and T2DM share demographic profiles , risk factors , and clinical and biochemical features in common.
Adolescence and old age are unique periods of the lifespan characterized by differential sensitivity to the effects of alcohol.
Adolescence is a critical age for addiction formation as a large percentage of pathological drug-seeking behaviors manifest during this time.
Adolescence is associated with the onset of puberty , shifts in social and emotional behavior and an increased vulnerability to social anxiety disorder.
Adolescence is a transitional period between childhood and adulthood and is characterized by emotional instability.
Adolescence is often described as a period of increased risk taking relative to both childhood and adulthood.
Adolescence is the time of peak onset for many anxiety disorders , particularly Social Anxiety Disorder.
Adolescence is typified by significant maturation in higher-level attention functions coupled with less developed control over motivation , and enhanced sensitivity to novelty and reward.
Adolescent and young adult medicine is a concept that has gained traction in the last decade or so.
Adolescent development encompasses an ostensible paradox in threat processing.
Adolescents and the elderly appear to be more vulnerable to many of alcohol's physiological and behavioral effects compared to adults.
Adolescents in the high-stress condition were more accurate than those in the low-stress condition , while children's accuracy did not differ across stress conditions.
Adolescents provided data on anger at the pretest and at a posttest administered @number@ months later.
Adolescents recruited greatest bilateral ventral striatum during reflected social self-evaluations , which was positively correlated with age and pubertal development.
Adolescents showed category selectivity bilaterally for faces in the FG and houses in the PPA.
Adolescents showed differential modulations of the amplitude also for irrelevant information at the P3b , suggesting less efficient processing.
Adolescents with fragile X syndrome showed decreased prevalence of functional-behavioral deficits.
Adolescents with intellectual disability ( ID ) can take advantage of SRF for enhancing work performance and enjoying participation with peers in leisure activities.
A domain-specific and then overall selection method based on adjusted R2 values was used to identify explanatory factors for the outcome.
A dominant theme was the construction of a post-menstrual identity.
Adopting a more holistic approach to their health care management is needed to achieve optimal health and well-being in the HIV-infected older adult.
Adopting an ecological approach to learning , the authors examined the process of attunement that is , the changes in what informational variable is exploited.
Adopting an environmental approach , we examined the effects of the caregivers ' spatial proximity on children's social behaviour.
Adopting a person-environment fit framework , we discuss how the roadway environment can be modified to better match the abilities of the aging driver.
Adoption of FLS programs improves care by lowering mortality and refracture rates while also lowering healthcare costs.
Adoption of previously unreported postural prioritization strategies may influence balance control in older people.
Adoption of this guidance will facilitate more accurate and interpretable research that will support the development of dietary recommendations regarding the intake of flavonoids.
Adoption rate and usability of such devices among the aging is far from being satisfactory.
A dose dependent acute toxicity to embryos of sea urchin was also determined.
A dose-dependent association between well-water arsenic concentration and kidney diseases was observed.
A dose-dependent increase in type @number@ procollagen was confirmed by AdMSC-conditioned medium.
A dose reduction is recommended in the elderly and in those with moderate renal function , but dabigatran etexilate is contraindicated in severe renal impairment.
A dose-response relationship exists between sarcopenia stages and functional limitations / disability.
A dose-response relationship was demonstrated with lifetime exposure ( p < 0.002 ) additional to that of tobacco and opioids.
A dose-response relationship was observed as frailty increased.
A double analysis of the collected speech was manually performed , then computerized by the Alceste® software.
A Double Pedalo is a four-wheeled device that involves standing on two connected platforms , and alternately pushing them forward to make it move.
A double Weibull function was selected as a suitable model since it could account for the typical biphasic nature of GE.
AD pathology is driven by genetic factors related not to aging per se , but instead to the amyloid precursor protein ( APP ) .
AD pathology was quantified according to Braak stage ( < 3 vs ≥ @number@ ) .
AD patients also identified significantly fewer odors than healthy participants of the same age.
AD patients always exhibited a higher number of errors as compared with HC.
AD patients showed higher MDA levels than both MCI and healthy elderly subjects.
AD patients showed higher number of errors as compared with aMCI only on RP and IC errors.
AD patients showed similar autobiographical performances in past and future event generation , and so did control participants.
AD patients were characterized by lower NAA / Cr in the frontal and posterior cingulate voxels.
AD patients were impaired relative to healthy controls ( NC ) and FTLD patients on both feature and conjunction search.
AD patients were particularly impaired by motion incoherence created by adding randomly moving dots to the optic flow.
Adper Single Bond @number@ and resin composite ( Filtek Z350 XT ) were applied to all specimens.
Adper Single Bond @number@ was applied in all specimens and resin composite buildups were constructed with Filtek Z350.
ADP-induced aggregation was unaffected by aspirin , while collagen-induced aggregation was reduced.
AD postmortem brain also showed signs of cellular injury , including decreased synaptophysin and drebrin , pre- and postsynaptic markers.
AD prediction tools for primary care are therefore needed.
ADP ribosylation factor GTPase-activating protein @number@ ( ARFGAP3 ) is a GTPase-activating protein that associates with the Golgi apparatus and regulates the vesicular trafficking pathway.
ADP-ribosylation factor @number@ ( ARF6 ) is a small GTPase necessary for regulating cellular structure , motility , and vesicle trafficking.
A draft questionnaire was refined with key intercept interviews of @number@ parents / caregivers ( phase B ) .
A dramatic decrease in the prevalence of infection occurred over the 19-year observation period.
A dramatic increase in NHL incidence was seen starting around @number@ with subsequent stabilization @number@ years ago.
Adrenal and gonadal steroids are associated to impairment of the ageing health condition in elderly individuals living independently in Spain.
Adrenal insufficiency was the cause of FUO in two patients.
Adrenocortical cells treated with bFGF showed a significant greater level of bFGF mRNA.
Adrenomedullin ( AM ) is a novel hypotensive peptide that exerts a variety of strongly protective effects against multiorgan damage.
AD research findings have already produced results , since recent epidemiological studies report a decreasing incidence of AD in the last years.
Adriamycin-induced aging was enhanced or suppressed , accompanied with inhibited or potentiated JAK2 signal pathway in sirtuin @number@ up-regulation or down-regulation cells , respectively.
A drop in fall rate was observed in the last month of the study.
ADR-related admissions were determined through expert consensus from detailed review of medical records and patient interviews.
ADR severity was rated moderate and severe in @percent@ and @percent@ of admissions , respectively.
ADSC are used as an alternative cell source for many different cell therapies , however in ischemic cardiovascular diseases the therapeutic benefit was modest.
ADSCs and HDFs were isolated from healthy donors and flow cytometry was used for immunophenotype identification.
ADSCs from aged patients both with and without CAD acquire aging characteristics , and their angiogenic potential declines because of decreasing proangiogenic factor secretion.
ADSCs from aged patients had shorter telomeres ( quantitative reverse transcription polymerase chain reaction ) and a tendency to attenuated telomerase activity.
ADSCs stimulated collagen expression and decreased MMP expression.
ADSCs were co-cultured with young or aged human dermal fibroblasts in Transwell plates , and control groups were established accordingly.
AD showed also decreased slow wave sleep ( SWS ) relative to healthy elderly individuals.
ADS level @number@ medicines such as amitriptyline , nortriptyline and oxybutynin were commonly prescribed in both groups.
Adsorbed HA and γ-globulin molecules significantly improved the frictional behavior of advanced OA cartilage , while they were ineffective for normal and early OA cartilage.
AD symptoms severity is reported to be more strongly correlated with the level of soluble amyloid-β ( Aβ ) assemblies.
AD transgenic mice were fed either folate-deficient or control diets and gavaged daily with water or folic acid ( @number@ μg / kg ) .
A dual luciferase reporter assay was used to demonstrate that bta-mir-10020 directly targeted the @number@'-UTR of the bovine ANGPT1 gene.
A dual requirement for CREB phosphorylation and CRTC dephosphorylation is likely to explain how these activator-co-activator cognates discriminate between different stimuli.
A dual-task gait test evaluating the cognitive-motor interface may predict dementia progression in older adults with MCI.
A dual-task paradigm was used to examine the effect of cognitive load on motor reprogramming.
Adult Acute Lymphoblastic Leukemia ( ALL ) therapies have been improved by pediatric-like approaches.
Adult BMHV flows demonstrate more disorganized small-scale flow features , but pediatric flows are associated with higher fluid shear stresses.
Adult-born neurons are integrated in preexisting networks and may have functional implications for adult brain.
Adult-born neurons have to integrate into the established neural circuitry throughout life.
Adult cardiorespiratory fitness was assessed using a submaximal exercise test to estimate maximum oxygen consumption adjusted for body weight in milliliters / minute / kilogram.
Adult CE cells lack regenerative potential , and the number of CE cells decreases throughout life.
Adult child caregivers have distinct psychological and physical health trajectories that are related to their roles over time.
Adult children achieved greater decision-making power than their frail parents , which evoked older adults ' ambivalent feelings.
Adult children worry about assuming responsibility for their parents ' transportation needs and their parents ' reactions to restricted mobility.
Adult cognition and age-related cognitive decline can be influenced by dysregulation of the hypothalamic pituitary adrenal axis with concomitant changes in cortisol levels.
Adult critical care medicine ( CCM ) is ill prepared for the demands of an aging US population.
Adult erythropoiesis in the bone marrow requires Epo that is secreted by renal Epo-producing cells ( REP cells ) .
Adult hippocampal neurogenesis involves proliferation , survival , differentiation and integration of newborn neurons into pre-existing neuronal networks.
Adult hippocampal neurogenesis is dynamic , responding to physiological and pathological stimuli that may promote brain function or contribute to diseases such as epilepsy.
Adult human brain expresses @number@ isoforms of tau protein as a result of alternative splicing.
Adult human thymus degenerates into fat tissue ( thymus adipose tissue ( TAT ) ) .
Adult , mature , elderly and long-lived human volunteers were used.
Adult mesenchymal stem cells are a resource for autologous and allogeneic cell therapies for immune-modulation and regenerative medicine.
Adult muscle stem cell ( or satellite cell ) replication and differentiation is compromised with age contributing to sarcopenia.
Adult native speakers reported the age at which they had learned each word.
Adult neural stem cells contribute to neurogenesis and plasticity of the brain which is essential for central regulation of systemic homeostasis.
Adult neurogenesis is modulated by a balance of extrinsic signals and intrinsic responses that maintain production of new granule cells in the hippocampus.
Adult neurogenesis is the process of producing new neurons from neural stem cells ( NSCs ) for integration into the brain circuitry.
Adult neurogenesis is well known to be regulated by stress , and conversely adult neurogenesis regulates stress responses.
Adult neurogenesis occurs in the subgranular zone of the hippocampal dentate gyrus and the subventricular zone of the lateral ventricles.
Adult obesity is associated with blunted luteinizing hormone ( LH ) pulse amplitude that is partially attributable to increased LH clearance rate.
Adult observers also identified the direction of motion for translational ( rightward vs. leftward ) and rotational ( clockwise vs. anticlockwise ) patterns.
Adult offspring's dispositional optimism was assessed with the Life Orientation Test-Revised ( LOT-R ) .
Adult oligodendrocyte precursor cells ( OPCs ) are located adjacent to demyelinated lesion and contribute to myelin repair.
Adult-onset NIHID typically manifests with dementia associated with leukoencephalopathy.
Adult-onset Werner syndrome ( WS ) and childhood-onset Hutchinson-Gilford progeria syndrome are the best known examples.
Adult participants showed cueing effects to line drawn faces as well as the other two types of face cue in Experiment 1b.
Adult romantic attachment styles reflect ways of relating in close relationships and are associated with depression and negative emotionality.
Adults aged @number@ and older who had consumed alcohol in the past year ( n = 13 , 265 ) were analyzed.
Adults aged @number@ and older within two counties were recruited ( control n = @number@ intervention n = @number@ ) .
Adults and 7-year-olds but not 4-year-olds selected the previously correct informant.
Adults and children showed evidence of articulated segmental control during gait.
Adults discredited informants who exhibited poor calibration , but children did not.
Adults elicited a set of neural markers that were broadly similar in preparation for encoding and during maintenance.
Adult SES partially explains the association between childhood abuse and MetS.
Adults in Brazil still face many years of cognitive impairment in their older years , particularly when compared with estimates from developed countries.
Adults in the obese category , 60-69 age group , and those in the highest socioeconomic status tertile were more likely to be physically inactive.
Adult skin stem cells are considered an attractive cell resource for therapeutic potential in aged skin.
Adults of both sexes born 1930-1959 showed secular gains and estimated rates did not differ.
Adults often miss a disturbingly high percentage of rare targets in visual arrays.
Adults older than @number@ years comprised only @percent@ of the US population in @number@ however , they accounted up to @percent@ of all ICU admissions.
Adults older than @number@ years of age with vision impairment are more likely to have difficulty managing medications compared with people having normal vision.
Adult somatic stem cells facilitate tissue homeostasis throughout the life of the organism.
Adult stem cell function declines during the aging process of an organism.
Adult stem cells are critical for maintaining cellular homeostasis throughout life , yet the effects of age on their regenerative capacity are poorly understood.
Adult stem cells are known to have a finite replication potential.
Adult stem cells exist in most mammalian organs and tissues and are indispensable for normal tissue homeostasis and repair.
Adult stem cells play a critical role in the maintenance of tissue homeostasis and prevention of aging.
Adult stem cell transplantation is a promising strategy for the treatment of stroke.
Adult survivors of childhood medulloblastoma exhibit signs of early aging regardless of how young they were at diagnosis.
Adults were divided into lower and higher perceived fatigability groups ( n = 22 per group ) .
Adults with arthritis were more likely to keep driving compared with those without arthritis.
Adults with ASD showed no atypicalities in activation of the EBA and FFA , whereas children with ASD showed atypical activation in these regions.
Adults with Down syndrome ( DS ) are at high risk for developing Alzheimer's disease after the age of @number@ years.
Adults with Down syndrome ( DS ) are at risk for developing Alzheimer's disease ( AD ) .
Adults with early-onset disability are more likely to have health or participation problems than adults with late-onset disability.
Adults with high myopia had a higher prevalence of nuclear cataract than adults without that ( OR = @number@ @percent@ CI @number@.055-6.062 ) .
Adults with IDs are routinely living longer.
Adults with more social interactions used more propositions when talking to a child.
Adults with other ID may have specific needs for dementia-related care that , if unmet , can lead to diminished quality of old age.
Adult worms were treated with conjugated Pt-nps for @number@ days.
Advance care planning is considered a best practice within health care.
Advance care planning was supported and welcomed , x advance care planning literacy was evident.
Advanced age and more severe depressive symptoms were the crucial predictor for multiple falls.
Advanced age and non-Caucasian race were independent predictors of adverse outcomes after BPH surgery.
Advanced age and sex , two of the most prominent risk factors for dementia , are not modifiable.
Advanced age does not represent a contraindication to surgery.
Advanced age , illiteracy , and living in an industrial area were found to be associated with dementia.
Advanced age increases the risk of developing complications post-surgery , but comorbidities are more important than age alone.
Advanced age is associated with an increased risk of vascular morbidity , attributable in part to impairments in new blood vessel formation.
Advanced age is associated with decrements in episodic memory , which are more pronounced in memory for associations than for individual items.
Advanced age is associated with more undiagnosed cerebrovascular disease and is a major risk factor for stroke and POCD following cardiac surgery.
Advanced age is associated with the finding of abnormalities on neurological and cognitive assessment.
Advanced age , lower education , and socioeconomic status were significantly correlated with the lower scores on the Female Sexual Function Index.
Advanced age presents distinctive obstacles to maintaining a physically active lifestyle.
Advanced age reduced the likelihood of AChEI consumption.
Advanced age was associated with greater rightward turning preference.
Advanced aging is accompanied by a decline in visuospatial attention.
Advanced bladder cancer is treated mainly with gemcitabine and cisplatin , but most patients eventually become resistance.
Advanced cardiovascular interventions and an aging population contribute to the growing prevalence of patients with heart failure ( HF ) .
Advanced Driver Assistance Systems ( ADAS ) especially designed to support older drivers crossing intersections might counteract these difficulties.
Advanced Glycated End Products ( AGEs ) are formed by non-enzymatic protein glycation and are implicated in several physiological aspects including cell aging and diseases.
Advanced glycation end-products ( AGE ) have been implicated in aging and the pathogenesis of diabetic complications , inflammation , Alzheimer's disease , and cancer.
Advanced glycation endproducts ( AGEs ) accumulate during aging.
Advanced glycation end products ( AGEs ) accumulate in the aging brain and could be one of the reasons for age-related diseases like PD.
Advanced glycation end products ( AGEs ) derived from glucose are implicated in osteoporosis and a number of diabetic complications.
Advanced glycation end-products ( AGEs ) form during oxidative stress , which is increased in diabetes mellitus ( DM ) .
Advanced glycation end products ( AGEs ) have been recognized as a pivotal inducer in diabetes and kinds of aging-related vasculopathy.
Advanced glycation end products ( AGEs ) play a pivotal role in loss of lens transparency , i.e. , cataract.
Advanced glycation end products ( AGEs ) , protein-bound oxidation products of sugar , might be one of those mitogenic compounds.
Advanced glycation end products ( AGEs ) seem to be involved in aging as well as in the development of cardiovascular diseases.
Advanced glycation end-products are key substances involved in the negative remodeling associated with diabetes.
Advanced hepatic fibrosis was defined by FIB-4 index > 3.25.
Advanced in vivo amyloid stages were most frequent in patients with AD and correlated with cognitive impairment in individuals without dementia.
Advance directive completion was associated with older age , more education , and higher income and was less frequent among non-white respondents.
Advance directives ( ADs ) are legal documents that allow individuals to convey their decisions about EOLC.
Advance directives were less frequent among those who reported not knowing if they had an EOL concern.
Advanced liver fibrosis must be included in the list of diseases associated with aging.
Advanced maternal age is a well-established factor of DS occurrence.
Advanced medicine has recently developed and expanded as part of health care reform.
Advanced oxidation processes ( AOPs ) are alternatives to the degradation of those organic wastes.
Advanced Parkinson's disease patients require for their care the participation of a multidisciplinary team.
Advanced paternal age has been suggested as a risk factor for autism , but empirical evidence is mixed.
Advanced processing techniques allow performing voxel-based analyses which are capable of detecting novel loci implicated in specific neuroplastic events beyond traditional regions-of-interest analyses.
Advanced surgical and anesthetic techniques have contributed to an increasing number of elderly and sicker geriatric patients undergoing surgery.
Advanced technical skills may have to be acquired for the specific treatment of this area using this particulate material.
Advanced TR and lower LVEDD are independent adverse predictors of mortality in patients with idiopathic RCMP.
Advancements in diagnostic modalities have allowed for earlier detection of glaucomatous disease , and subsequent earlier intervention when appropriate.
Advancements in diagnostic tools and curative-intent therapies have improved cancer-specific survival.
Advancements in imaging techniques enable us to directly and noninvasively study the role of adiposity on skeletal health.
Advances are being made in vehicle technologies that may help older adults compensate for some of the declines in abilities associated with aging.
Advances in automatic text classification have been necessitated by the rapid increase in the availability of digital documents.
Advances in bone imaging techniques have provided tools for analyzing bone structure at the macro- , micro- and nano-level.
Advances in CR research on non-human primates and recent endeavors using human subjects offer a promising outlook for CR's beneficial effects in healthy human aging.
Advances in genetics and experimental model systems have illuminated an important role for defects in intracellular transport pathways to lysosomes.
Advances in healthcare and in the quality of life significantly increase human life expectancy.
Advances in health , increased awareness of preventative medicine , and evolution have led to an increasingly older population worldwide.
Advances in medical care allow people to live longer and better lives.
Advances in molecular pharmacology have increased our understanding of INSL3 interaction with its specific receptor , RXFP2 , and delivered new high-affinity antagonists.
Advances in networking , sensors , and embedded devices have made it possible to monitor and provide assistance to people in their homes.
Advances in neuroscience demonstrate that the reduction of telomere length by anxiety and stress leads to more rapid aging and potential disease vulnerability.
Advances in nutritional geometry have begun to unravel and integrate the interactive effects of multiple nutrients on health , lifespan , aging , and reproduction.
Advances in our understanding of the genetic basis of eye diseases will enable better characterization of ocular health and disease.
Advances in our understanding of the role of cardiovascular risks have shown them to be closely associated with cognitive impairment and dementia.
Advances in pharmacological treatment and effective early myocardial revascularization have led to improved clinical outcomes in patients with acute myocardial infarction ( AMI ) .
Advances in public health in the past century have seen a sharp increase in human life expectancy.
Advances in radiotherapy technology have changed the way radiation is planned and delivered.
Advances in research on mitochondria have elucidated their importance in cell survival and cell death regulation in addition to their function in energy production.
Advances in retinal imaging may provide new and potentially important insights into cerebrovascular neurodegenerative processes in addition to what is currently possible with neuro-imaging.
Advances in this field have enabled introduction of some the most effective treatments yet described for HSDD.
Advances in this field require new tools with which to recreate neural tissue in vitro and produce realistic disease models.
Advancing age brings changes to all components of the integumentary system with consequent signs on the skin.
Advancing age but not sex remained significant ( P < @number@ ) .
Advancing age , distal or proximal weakness and RLD characterized all non-survivors ( n = 14 ) .
Advancing age influenced the subjective impact of the slides and gait characteristics , but did not modulate medio-lateral shifts.
Advancing age is a major risk factor for coronary artery disease.
Advancing age is a major risk factor for the development of cardiovascular diseases.
Advancing age is associated with an increase in physical impairment , functional limitations , disability , and loss of independence.
Advancing age is associated with a progressive loss of skeletal muscle ( SkM ) mass and function.
Advancing age is associated with cognitive and motor performance deficits and a reduced capacity for plasticity.
Advancing age is associated with decrements in selective attention.
Advancing age is associated with increased mortality even after controlling for preexisting morbidity.
Advancing age is associated with progressive declines in physiological function that lead to overt chronic disease , frailty , and eventual mortality.
Advancing age is the major risk factor for the development of chronic diseases and is accompanied by changes in metabolic processes and mitochondrial dysfunction.
Advancing age is the major risk factor for the development of CVD ( cardiovascular diseases ) .
Advancing age was associated with a higher incidence ( p < 0.
Advancing age was associated with greater Phi2 among both EA and AA.
Advantages and shortcomings of recent techniques for muscle proteome analysis are discussed.
Advantages of darker skin include increased photoprotection , slowed aging , and a lower incidence of skin cancer.
Adventitial VV strongly correlated with its own cIMT only in the left carotid artery.
Adverse atrial remodeling is associated with increased risk of atrial fibrillation ( AF ) and can be detected by a shift in P-wave axis.
Adverse cardiovascular events including stroke , acute coronary syndrome , or heart failure ; major bleeds ; and mortality were recorded during more than
Adverse drug reactions ( ADRs ) are an important health issue.
Adverse drug reaction severity was ' moderate ' in all cases.
Adverse drug reactions were experienced by @percent@ of the safety population over the 6-month study period.
Adverse effects , forgetfulness and patient ignorance are multiple reasons for the hesitancy to begin drug management.
Adverse effects including poorer energy and fluid intake were identified.
Adverse effects of current lipid-lowering agents can be dose-limiting , and combination approaches to lipid-lowering may often be utilized for optimal CV risk reduction.
Adverse effects of this hyaluronidase are uncommon with local injection site reactions most frequently reported.
Adverse effects were frequently not reported.
Adverse effects were mild and temporary.
Adverse effects were mostly graded mild.
Adverse effects were similar between the study group and the control group.
Adverse events ( AEs ) observed during the 24-week CZP treatment period were recorded.
Adverse events ( AEs ) were documented to evaluate safety.
Adverse events and cost explained @percent@ and @percent@ of discontinuation.
Adverse events and discomfort associated with the treatment were also assessed.
Adverse events and patient satisfaction were also evaluated.
Adverse events and tolerability were recorded.
Adverse events and treatment site reactions were recorded.
Adverse events are often due to the thinness of the dermis and epidermis and the lower concentration of pilosebaceous units.
Adverse events comprised CVD death , myocardial infarction , coronary insufficiency , index admission for heart failure , and stroke.
Adverse events decreased over time ( @percent@ to @percent@ , P < 0.001 ) .
Adverse events included erythema and edema , and transient visibility of the injection sites.
Adverse events , including instances of hyperostosis , cardiovascular events , osteoarthritis , and cancer , appeared to be balanced between the groups.
Adverse events judged to be more severe or prolonged than routinely observed were recorded.
Adverse events may occur , although they are mostly minor , self-limiting , and short-lived.
Adverse events reported were typical of dermal filler injections with respect to type , rate , duration , and severity.
Adverse events seen during this analysis were found to be minimal and not of clinical significance.
Adverse events steadily increased , from @percent@ at @number@ days , @percent@ at @number@ days , and @percent@ at @number@ months.
Adverse events were also evaluated.
Adverse events were documented.
Adverse events were equally distributed.
Adverse events were generally mild.
Adverse events were limited to overcorrection in @number@ patients ( @percent@ ) .
Adverse events were mild and transient.
Adverse events were mild and transient with no incidence of burns , seromas , hematomas , infection , or nerve damage.
Adverse events were monitored throughout.
Adverse events were monitored throughout.
Adverse events were rare and of mild severity.
Adverse events were recorded.
Adverse events were recorded.
Adverse events were recorded.
Adverse events were recorded.
Adverse events were recorded and subjects self-assessed the appearance of their platysmal bands versus baseline.
Adverse events were recorded at each evaluation session.
Adverse events were reported by @percent@ of all participants ; no between-group differences in total adverse events were statistically significant.
Adverse events were reported via medical interviews.
Adverse events were similar in the two groups.
Adverse health consequences of sarcopenia are falls and loss of independence , increased health costs and reduced quality of life.
Adverse health outcomes ( ADL and IADL disability , healthcare utilization , GDS-15 , SSRS ) were used to assess predictive ( concurrent ) validity.
Adverse-outcomes related to sarcopenia are mostly mentioned as physical disability.
Adverse outcomes , such as hospitalizations and falls , have been shown to be associated with polypharmacy.
Adverse socioeconomic conditions are associated with increased plasma levels of these molecules , especially interleukin ( IL ) -6.
Adverse symptoms after the last prescription were reported by @number@ ( @percent@ ) subjects.
Adversity early in life may alter pathways of aging , but what interpretive processes can soften the blow of early insults ?
Advertisements and public notices were used to recruit a convenience sample of healthy women.
Advocates of incentive programs have proposed an ambitious research agenda for moving patient incentive programs forward.
Advocates of the person-centered approach argue that emotions and interpersonal responses may remain intact.
AD was calculated as maximum change in area / ( minimum area × pulse pressure ) .
AD was lowest among those with DM.
AD was not associated with non-calcified coronary plaque or when age was added to the models ( all p > 0.39 ) .
A / D was positively associated with total amygdalar volume ( p = 0.045 ) , independent of age and sex.
A dysfunction in this pathway as a result of aging can result in multiple abnormalities in several physiological systems.
Ae. albopictus is naturally double-infected with two Wolbachia strains , wAlbA and wAlbB.
Aedes aegypti is the main vector for yellow fever , dengue , chikungunya and Zika viruses.
AEDs should be introduced cautiously based on patient's frailty and starting with lower dosage.
AEE was calculated as : TEE ( @number@ ) -RMR.
Aerobic capacity , timed standing and grip strength improved and waist circumference decreased.
Aerobic exercise and respiratory training were effective in improving the pulmonary parameters.
Aerobic exercise exerts its beneficial effects on arterial function by modulating structural proteins , reducing oxidative stress and inflammation , and restoring nitric oxide bioavailability.
Aerobic exercise has been suggested to ameliorate aging-related decline in humans.
Aerobic exercise in young adults can induce vascular plasticity in the hippocampus , a critical region for recall and recognition memory.
Aerobic exercise may also promote \ "resistance \ " against factors that reduce vascular function and increase CVD risk with age.
Aerobic exercise , mental activity , and social engagement may help decrease risk of further cognitive decline.
Aerobic exercise produced the reduction of plasma IL-6 levels.
Aerobic exercise training increased proteins involved with mitochondrial biogenesis , fusion , and fission , independent of age.
Aerobic exercise training significantly increased the antegrade shear rate and decreased the retrograde shear rate and brachial artery IMT.
Aerobic fitness and adiposity could only partly account for the differences.
Aerobic fitness improved significantly in participants in the MI-WP.
Aerobic metabolism , while enabling efficient energy production , also generates reactive oxygen species ( ROS ) , which damage cellular components.
Aerobic plate counts ( APC ) , coliform and yeast / mold counts were also performed.
Aerobic training is an effective method to maintain and improve cardiovascular function.
Aerosol NNR depends on vaping technique and time elapsed since the e-liquid was exposed to air.
Aerosp Med Hum Perform.
AEs and chemotherapy modification were recorded.
AEs largely resolved after intervention discontinuation.
AE's pronounced relational STM binding deficits contrasted with his completely preserved conjunctive binding functions in both Experiments @number@ and @number@
Aesthetic change was evaluated independently by the subject and a blinded evaluator.
Aesthetic improvement of the neck and cervicomental angle remains one of the most challenging aspects of surgical facial rejuvenation.
Aesthetic medicine proposes worthy alternative and / or appropriate complementary solutions.
Aesthetic providers need to be well versed in the anatomy and intricacies of the skin.
AEs were distributed across different ages , skin types ( @percent@ Type II , @date@ % Type IV ) , and laser parameters.
AEs were reported in @number@ ( @percent@ ) patients , at an event rate ( ER ) of @number@.68 / 100 PY.
A European guidance regarding most adapted evaluation instruments of frailty is currently under public consultation.
AEX + WL had no effect on phosphorylation of Akt or AS160.
AEX + WL increased VO2max by @percent@ ( p < @number@ ) and decreased body weight ( @percent@ , p < @number@ ) .
AF3442 caused a concentration-dependent inhibition of PGE ( @number@ ) in human recombinant mPGES-1 with an IC ( @number@ ) of @number@.06microM.
A face-to-face survey of the residents addressed physical , social / cultural , economic , and service issues.
A face-to-face survey of the residents addressed physical , social / cultural , economic , and service issues.
A factor analysis demonstrated the overall continuity across the IADL-ADL continuum.
A factor analysis revealed four factors that captured different aspects of non-adherence.
A factor that has proven critical for general individual differences in visual working memory capacity is the efficiency of filtering irrelevant information.
A factor that potentially influences on skin aging is blood supply which determines global conditions for an organ or a tissue functioning , including skin.
A failure of redox signaling occurs in muscle during aging and may contribute to the age-related loss of muscle fibers.
A failure to consider voiding difficulties can precipitate a crisis and simple strategies such as teaching self-catheterization and using estrogen cream may prevent problems occurring.
A fall detection algorithm has been designed therefore to cope with large variations of movement in the torso.
A false discovery rate correction was applied separately within the results for each ethnicity to correct for multiple testing.
A familial Alzheimer's disease Chinese family , with @number@ affected family members , underwent PSEN1 screening in @number@ affected family members.
A familial behavioral variant frontotemporal dementia associated with astrocyte-predominant tauopathy is described in @number@ sisters born from consanguineous parents.
A family history of finger nodes was negatively associated with absence of hip and hand OA.
AF and HF , instead of representing distinct disease processes , often represent different endpoints along a disease continuum.
A farnesyltransferase inhibitor reduced these nuclear abnormalities and significantly prevented embryonic senescence and muscle fiber damage induced by zProgerin.
A faster proliferative capability was seen in both iPSC-MSCs lines compared to the BM-MSCs.
A faster utilization of these mechanisms due to improved neuromuscular coordination resulted in the significant performance enhancement.
A fasting blood sample was taken to measure glucose and lipid concentration.
A favourable attitude toward ASH and a sense of having less control regarding these drugs predict both current usage and intention to continue.
AFB may be associated with CVD both through physiological and sociobiological pathways.
AF cases were identified during the yearly study electrocardiograms , participant history of a physician diagnosis , or by hospitalization data.
AF developed at 49±17 years.
A ' fear-avoidance ' model is often used to explain avoidance of activity in the face of pain.
A feature selection algorithm was used to select those able to classify subjects at risk and not at risk for several classification algorithms types.
A few insights into the role of antioxidants in mitigating oxidative stress caused by therapeutic compounds or drug carriers are also discussed.
A few methods are reported to solve this problem , including using a dental appliance , local tissue rotation , or even free-tissue transfer.
A few miRNAs were differentially expressed in WM , including miR-212 that is downregulated in AD and miR-424 which is upregulated in AD.
A few restricted regions of higher density were detected in the right hemisphere.
A few specific randomized studies have shown a benefit for radiotherapy in elderly patients with good performance status.
A few studies , however , have investigated the longitudinal relationship between raised inflammatory biomarkers and persistence of depressive symptoms.
A few studies of SHBG in rats were reported , but systemic SHBG studies in consideration of different organs and aging are currently missing.
A few tested make up products show variable effects that closely correlate with visual assessments made by trained estheticians.
Affect complexity was examined using clusterwise simultaneous component analysis based on covariance matrices to take into account differences in affect variability.
Affected children usually have a median life span of @number@ years.
Affected lenses showed capsule rupture at the posterior pole , with expulsion of the lens nucleus and degenerating fiber cells.
Affected mice had other neoplasms , such as lymphoma and anemia.
Affected patients display typical features of premature aging.
Affected tissues are those that require constant renewal by stem cell activity.
Affective disturbances and stress are proposed to increase corticosteroid-induced hippocampal damage in many different ways.
Affective effects emerge even in nonaffective contexts.
Affective function remained stable through the experiment.
Affective status was determined using the geriatric depression scale.
Affect was assessed using observations of the @number@ moods from Lawton's Modified Behavior Stream.
Afferent noise may also be generated by local ACh release within the detrusor muscle.
A FI comprised of @number@ health-related deficits was developed from a review of the literature and consultation with a veterinarian.
A fifth miRNA , mir-6722 , was down-regulated in persons with AD and mild cognitive impairment compared with controls.
A fifth rater used only the new definition.
A figure illustrating the above facial creases is included as reference.
A filter-assisted microfluidic device was designed to enrich MVs directly from pRBC units , and label them with target-specific magnetic nanoparticles.
A final model included measures showing an association with p < @number@
A final section deals with protection against infrared radiation.
A final selection of seven articles was used for the present manuscript.
A final set of analyses suggested that impaired olfactory performance may aid detection of underlying Lewy body disease.
A final theme described barriers to further utilization.
A final tool ( BFH-OSTM ) was based on body weight and fragility fracture history only.
AF incidence was @percent@ higher and PA was @percent@ lower in winters than in summers ( p < 0.0001 for both comparisons ) .
A firm understanding of the mechanisms regulating proteostasis in stem cells will pave the way to innovative stem cell-based interventions to improve healthspan and lifespan.
A first clinical application was carried out.
A first manic episode in ageing can be secondary to medical illness.
AF is an expression of underlying heart disease and is increasingly associated with hypertension , congestive heart failure , and ischemic heart disease.
A FI score was determined for each rat every 3-4 months , and for the older group mortality was assessed up to @number@ months.
A five-min delay was inserted between the first three recall trials.
A five-step Delphi consensus process was used.
A fixed effects multilevel cross-sectional linear model was used to analyse the explanatory efficiency variables.
A flatbed scanner with resolution capabilities of @number@ dpi or greater allows for images of human bones.
Aflibercept ( Eylea Objective : To report descriptive and normative data for the Montreal Cognitive Assessment ( MoCA ) in a population-based African American sample.
A flow cytometry using annexin V -FITC and propidium iodide ( PI ) staining revealed a significant increase in apoptotic RECQL1 ( - ) cells.
A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed.
A fluorodeoxyglucose positron emission tomography study of brain metabolism shows different metabolic phenotypes among subjects with different educational levels and ApoE genotypes.
AFM analysis reveals distinct regional nanomechanical profiles that underlie aging-dependent tissue degeneration and OA.
AFM images of most of the younger subjects showed typical step-like topographic properties with clear scale edges.
A focus group ( FG ) method was used to gather the views and experiences of multi-professional HIV specialists who worked in North West England.
A focus group of five men was interviewed and two women were interviewed as a pair.
A focus on older adults ' life-space mobility may assist early identification of persons , who have elevated risk for depressive symptoms.
A foil word also was shown on the screen.
A follow-up analysis detected white matter associations with rs5882 in the opposite direction in @number@ older individuals ( @number@ ± @number@ years ) .
A forced change of shift against the nurses ' will was significantly associated with a deteriorating work ability and health.
A force field was used to add novel dynamics.
A formal cognitive assessment and history of acute onset of symptoms are necessary for diagnosis.
A formal test for checking the truncation time distribution is constructed based on the semiparametric likelihood ratio test statistic.
A form of single-item cognitive assessment is proposed in the NHS England and Wales dementia strategy.
A four-factor model of the NPI including behavioral dyscontrol , psychosis , mood , and agitation subscores was also analyzed.
A fourfold increase in incidence , a prolonged survival , and major changes in diagnostic methods in Norway were observed.
A four-step implementation process is proposed.
AF patients were prescribed antihypertensive drugs , especially diuretics , but less frequently statins.
AF progression rate was @percent@ per year , @percent@ at @number@ years , and @percent@ at @number@ years.
A fraction of the discovered compounds belongs to the group of fluorophosphates ( phosphorofluoridates ) which are in suspect of potential toxicity.
A fraction of this PS is shed into the extracellular milieu.
A fragment of the Hh-responsive GLI2 transcription factor directly binds and inhibits the p16 promoter and senescence is associated with the loss of nuclear GLI2.
A frailty index ( FI ) was generated , with the presence of frailty defined as an FI > 0.35.
A Frailty index ( FI ) with @number@ items was developed using Rockwood's cumulative deficits method.
A frailty index was calculated as the number of deficits present out of @number@ health variables.
A framework analysis approach was used to thematically analyse the data.
A framework for excluding potentially confounding disease and a working clinical tool to diagnose frailty have been provided.
A free testosterone index ( FTI ) was calculated.
A frequent and striking finding in functional imaging studies is that older adults recruit additional regions relative to young adults performing the same task.
African American / black enrollees were most likely to come from community liaison organizations.
African American elders were more likely to have used MBT than other racial or ethnic groups.
African American families ' experiences with mild cognitive impairment ( MCI ) have received little attention in the research literature.
African-American older adults are even less likely than their White counterparts to seek and engage in mental health treatment.
African-American players gained @number@ years on their respective referent and live longer than white men in the general public.
African Americans also added more confidants than whites.
African Americans also have much higher rates of vitamin D deficiency.
African Americans also showed higher circulating sphingomyelin concentrations compared to Caucasians.
African Americans and Hispanics had higher spirituality , which was associated with an increase in psychological HRQOL.
African Americans are disproportionately represented in the number of grandparents raising their grandchildren.
African Americans are more likely to experience initial olfactory decline , consistent with an earlier onset of aging among this subgroup.
African Americans had a significantly lower level of ERα and SFRP1 methylation than Caucasians and Hispanics.
African Americans had higher lifetime LGBT-related discrimination , which was linked to a decrease in their physical and psychological HRQOL.
African Americans had lower mean adequacy ratio scores than whites ( @number@ vs. @number@ ) .
African Americans had significantly lower prevalence of incontinence and falls , but higher prevalence of dementia ; Latinos had a lower prevalence of falls.
African Americans had statistically significant increased mean ILB measurements compared with whites.
African Americans have higher rates of type @number@ diabetes ( T2D ) and some forms of cardiovascular disease ( CVD ) than do European Americans.
African Americans reported more external locus of control , which was associated with smaller training gains.
African Americans report more external locus of control than non-Hispanic Whites , and external locus of control is associated with poorer health and cognition.
African Americans typically exhibit similar or better mental health outcomes than whites , an unexpected pattern given their disproportionate exposure to psychosocial stressors.
African American women had a longer duration of hot flushes than white women in adjusted analysis.
AFs are difficult to categorize ; therapeutic options are non-operative treatment with plaster casts or surgical treatment with Kirschner's wires , plates and screws.
AFS cells have a high renewal capacity and can be expanded for over @number@ doublings without any detectable loss of chromosomal telomere length.
After 10-15 years , @number@ people were evaluated and @number@ had died.
After 10-year follow-up in elderly twins , the variation in DNA methylation showed a similar pattern of change as observed cross-sectionally.
After 11-12 d treatment , PRX-treated adolescent rats showed a significant inhibition of social interaction while adults were unaffected.
After 2min of rest , 1Hz stimulation was repeated.
After 4months of use , the sole stiffness increased by @percent@ and the energy loss capacity decreased by @percent@ ( p < 0.001 ) .
After 6-14 months from the baseline , @percent@ individuals were re-assessed , @percent@ died and @percent@ dropped out for several reasons.
After 6-months , the participants were re-randomized to moderate intense physical activity ( PA + ) or non-physical activity ( PA- ) .
After a 12-hour fast , volunteers consumed a breakfast with a fat composition similar to that consumed in each of the diets.
After a 12-month follow-up period , @number@ ( @percent@ ) residents died.
After a 24-week follow-up period , SVR was evaluated.
After a 48-h period of physical activity avoidance and a 10-h overnight fast , fasting venous blood samples were obtained from each participant.
After a 5-minute wash-out period , the procedure was repeated using the second bleach modality.
After about age @number@ years , A + T + N + was most prevalent.
After acclimation , the dorsal skin was harvested and the hair cycle phase was identified histologically and immunohistochemically.
After accounting for childhood baseline performance on the same cognitive tests , there was no association between cardiorespiratory fitness and midlife cognitive functioning.
After accounting for the vascular factor , systolic and diastolic blood pressure measurements were not significant predictors.
After a comprehensive evaluation , presbyphonia may be treated conservatively with voice therapy or with a range of interventions.
After a comprehensive search of the literature targeting tools commonly used by occupational therapists , @number@ studies were reviewed and synthesized.
After a consensus meeting , the operationalizations of the dimensions were reviewed by the European Working Group of People with Dementia ( EWGPWD ) .
After a couple of weeks of treatment with levothyroxine and liothyronine , there were clinical and laboratory evidences of an improvement in the patient's condition.
After aCT , the control group did not show any significant effect either on FC or neuropsychological tests.
After acute myocardial infarction , β-adrenergic blockers reduce mortality regardless of patient age.
After additional control for baseline AL , this association was attenuated to marginal significance.
After addition , both types of particles rapidly induce autophagy in leukemia cells.
After addition of a complex I inhibitor , mitochondrial morphology is distinctly shifted to punctate forms in both cell lines.
After a decade , the prevalence of vitamin B2 and vitamin A deficiencies rose to @percent@ of the sample.
After a diagnosis of dementia , @number@ individuals ( @percent@ ) persisted on warfarin therapy.
After adjusting age and body mass index ( BMI ) , serum FSH still had markedly negative correlation with BDR at various skeletal regions.
After adjusting for age and gender , the correlation coefficient between aASM and IQS was @number@ ( P < @number@ ) .
After adjusting for age at death , the only significant difference was greater densities of temporal lobe NFTs within the aMCI group.
After adjusting for age , center , and BMI , higher levels of IGFBP-1 were associated with lower eBMD.
After adjusting for age , fitness , and body mass index , echocardiographic and morphometric differences among groups were attenuated and no longer significant.
After adjusting for age , the risk increased to @number@ times higher ( @percent@ CI , @date@ @number@ p = @number@ ) .
After adjusting for all factors , grip strength remained significantly associated with dementia ( p < 0.0001 ) .
After adjusting for baseline constructional praxis , the group comparison was no longer significant.
After adjusting for baseline differences , significant improvement was observed in mental health composite scores , but not in physical health composite scores.
After adjusting for baseline values , ΔSBP and ΔPP increased by @number@ mm Hg per year for every additional @number@ years from baseline.
After adjusting for childhood IQ and social class in general linear models , associations with age @number@ IQ and g factor were nonsignificant or attenuated.
After adjusting for cognitive abilities , associations between health literacy , physical health , and depressive symptoms were attenuated and no longer significant.
After adjusting for confounders ( physical functional ability and depressive symptoms ) , the association became non-significant.
After adjusting for covariates , asthma , chronic lung disease , arthritis and the number of physical conditions were associated with depression.
After adjusting for multiple comparisons , a significant association was found between ADAM10 SNP rs514049 and APPα levels.
After adjusting for physical activity , the MTH ratios were still not correlated with ratio of muscle strength.
After adjusting for practice effects the longitudinal changes were less positive at younger ages and slightly less negative at older ages.
After adjusting for resident characteristics , there is little variation in self-care disability associated with long-term care home characteristics.
After adjusting for SES , the ethnic HR was no longer significant ( HR = @number@ @percent@ CI = @number@.83-1.61 ) .
After adjusting for sociodemographic and vascular risk factors , blood pressure was the strongest correlate of cognitive performance.
After adjusting for symbol digit modalities test score , all significant group differences in cognitive functioning disappeared.
After adjustment , age did not increase the risk of death up to @number@ years.
After adjustment for age and other possible confounders , the association between pain status and both LH and FSH persisted.
After adjustment for age , a significant inverse trend of LTL with all-cause mortality was observed in both cohorts.
After adjustment for age , gender , and education , right hippocampal volume explained @percent@ of the variance in allocentric navigation in aMCI group.
After adjustment for age , sex , education , and baseline cognition , baseline frailty status significantly associated with Alzheimer's disease and dementia and death.
After adjustment for a large number of potential confounders , there was no significant association between the Western DP and HA.
After adjustment for baseline covariates , neither HF types nor dementia disorders were independently associated with survival.
After adjustment for CD4 counts and age , HIV infection was associated with higher AMH.
After adjustment for cerebral volume , only cerebellar gray matter volume remained borderline significantly associated with global cognition and information processing speed.
After adjustment for confounders , job strain predicted degenerative MSDs among women after @number@ and @number@ years of follow-up.
After adjustment for confounders , these associations remained significant in men but not in women.
After adjustment for confounding factors , worse survival of treated patients ≥75 years persisted.
After adjustment for confounding variables , sarcopenia showed a significant association with HOMA-IR in the non-obese group ( P < 0.001 ) .
After adjustment for covariates , each @number@ μmol / L increment of homocysteine corresponded with @number@ ( @number@ @number@ ) %5 mC higher LINE-1 methylation.
After adjustment for covariates , higher levels of mastery and self-efficacy were associated with decreased odds of functional decline , but not mortality.
After adjustment for depression and cognition , this association was no longer significant.
After adjustment for other covariates , the significance remained.
After adjustment for other prognostic factors and treatment , comorbidity maintained its independent prognostic value in a multivariate Cox regression analysis.
After adjustment for putative confounding factors , the associations became non-significant with OSF and CSF but persisted for SFD.
After adjustment for sociodemographic and health characteristics , technology use decreased significantly with greater limitations in physical capacity and greater disability.
After adjustment for the effects of confounding influences , we found no associations between diet and physical performance among men.
After adjustment for time-dependent confounding , the positive associations between indicators of intubation and of cognitive impairment and next-day delirium became stronger.
After adjustment for time-dependent fracture status , results were attenuated and not statistically significant.
After adjustment for within-person variation in DLW-determined PAEE , the correlations for TAC per day increased to @number@ and @number@ respectively.
After adjustment , HbA1c levels were not associated with the presence or absence of incontinence.
After adjustment , lower isokinetic work was associated with significantly greater risks of PSLL and mortality across the full measured range.
After adjustment of mortality rates , it appears that much of this increase is due to the aging population.
After adjustments for confounders , high DGI-2013 scores were associated with lower HDL-cholesterol , lower waist : hip ratios and lower probability of being frail.
After adjustments , older RBC age was associated with significantly increased risk for hospital mortality.
After adjustment , sun index and body mass index were associated positively and negatively , respectively with serum 25 ( OH ) D independently.
After adjustment , TC ( continuous or dichotomous ) was not associated with mortality from @number@ to @number@ @number@ to @number@ or @number@ to @number@
After advanced age , female sex is the major risk factor for Alzheimer's disease ( AD ) .
After age correction , NfH ( SMI35 ) levels were found to be higher in all disease stages compared to control.
After age @number@ all cognitive abilities showed evidence for statistically significant declines , although the magnitude of these changes varied considerably.
After age @number@ years , this study shows that testicular volume decreases significantly.
After age of @number@ years , the testicular volume significantly declines , while testicular metabolism progressively declines until age @number@ years.
After aging has occurred , common therapeutics such as oximes cannot reactivate the cholinesterase enzyme and relieve cholinergic inhibition.
After aging , MH ( p = @number@ ) and VL ( p = @number@ ) cemented with VAR showed higher results than CSA.
After aging the specimens for @number@ year , bond strengths decreased.
After a linear effect of time was accounted for , visit-to-visit changes in rFTC correlated with visit-to-visit changes in all @number@ cognitive tests.
After all , these new findings have paved novel directions in osteoporosis research.
After all these phases , @number@ manuscripts met the inclusion criteria of the review.
After almost three years of activity , many achievements have been obtained through commitments or collaborative work of the Action Groups.
After a mean follow-up of @number@ years , @number@ men and @number@ women developed new CHD events.
After a mean follow-up of @number@ years , we repeated the cognitive assessments with the same subjects.
After a median follow-up period of @number@ years , BFP was significantly higher than that at the start point ( P < 0.05 ) .
After a median of @number@ years follow-up , we documented a total of @number@ new cataracts.
After a median of @number@ years , @number@ persons were included in the Renal Iohexol-Clearance Survey Follow-Up Study.
After a median time of follow-up of @number@ days , @number@ deaths occurred.
After a meta-analysis including > 300 , 000 European samples , we identified an additional nine novel loci.
After a narrowed search through a set of specific inclusion and exclusion criteria , @number@ articles were used in this review.
After an average follow-up of @number@ years , @number@ participants had repeated COGTEL testing and were eligible for analysis.
After an average follow-up of @number@ years , @number@ persons ( @percent@ ) aged 65-79 years took part in a reexamination in @number@
After an average of @number@ years of follow-up , @number@ participants developed incident AD.
After andropause or menopause , the levels of androgen and estrogen in the hippocampus may significantly decrease , inducing dementia , Alzheimer's or depression.
After an initial extraction , we searched for primary studies in academic databases and grey literature to fill gaps in evidence.
After an overnight fasting , serum levels of bioactive IGF1 , total IGF1 and IGF-binding protein @number@ ( IGFBP1 ) and IGFBP3 were assessed.
After a period of exposure to chronically elevated levels of allopregnanolone , impaired learning and memory pattern occurred in the AD mice.
After a phase of energy balance , we fed participants in phase @number@ by a mean of @percent@ of their needs for @number@ days.
After application of quality measures , results were aggregated in a random effects analysis.
After applying exclusion criteria , the final sample size for analysis consisted of @number@ individuals.
After applying prior agreed inclusion and exclusion criteria , @number@ reports were included in the review.
After applying this definition in relation to populations of older adults , @number@ chronic ICD-10 codes were identified and grouped into @number@ chronic disease categories.
After appropriately marking the skin , the filler is placed using a blunt cannula.
After approval , the FDA required a Post-Market Registry to assess performance.
After a prompt evaluation of the patient , the OGU approach can achieve clinical stabilization prior to intervention.
After a random preparation interval ( PI ) of 100-850ms following the onset of the cue signal , a single-target stimulus indicated the required response.
After a retention interval , participants completed a surprise recognition memory test.
After artificial aging by thermocycling the shear-bond strength was measured.
After artificial aging , the mean bond strength of all groups dropped , but the decrease in the glaze group was not statistically significant.
After a series of sorting task laboratory sessions , multidimensional scaling and hierarchical cluster analyses revealed four clearly defined groups representing types of portrayals.
After a short delay , the second , re-presentation , phase involved passively viewing the aversive images from the reappraisal task.
After a spinal anesthetic was placed , a dose of dexmedetomidine determined by the Dixon up-and-down method was administered over @number@ minutes.
After a thorough preoperative evaluation , the corresponding operations were performed and the follow-up results were obtained.
After a washout period of @number@ week , the two interventions were switched to the other in the second treatment phase.
After being cultured with SIN treated MSC-conditioned medium ( stMSC-CM ) , the amount of TRAP-positive multinucleated osteoclasts differentiated from RAW264.7 cells was reduced.
After birth , there is striking biological and functional development of the brain's fiber tracts as well as remodeling of cortical and subcortical structures.
After birth , trisomy 21-mediated premature aging of stem / progenitor cells may contribute to the progressive multi-system deterioration , including development of Alzheimer's disease.
After Bonferroni correction , the few associations found between cerebellar volume and cognition disappeared.
After careful clinical examination and paraclinical assessment , the diagnosis of progeria syndrome was raised.
After cataract surgery , not only static vision of the patients was restored markedly , but also the dynamic vision.
After cCR , a significant negative correlation between Stroop Color-Word Interference Test and FC in the PCC emerged.
After CD45 ablation , in vitro and in vivo studies demonstrate an anti-Aβ phagocytic but proinflammatory microglial phenotype.
After centrifugation , POS are located in a discrete band in the upper part of the gradient that has a characteristic orange color.
After CGA , mean drug use and the prevalence of polypharmacy increased.
After checking Hardy-Weinberg equilibrium , we used using linear regression to evaluate the genotype treatment interaction for each outcome.
After checking reference lists and field experts , all key journals were hand searched.
After clinical onset of AD , there was no significant decrease of BMI.
After closure , e ' decreased by similar amount in both groups ( p < @number@ ) .
After combing and preservation of the living lice , the hair was wet with tap water.
After complete zonulectomy , the fixture-capsular bag assembly was removed from the eye and loaded onto a mechanical tester.
After completing all of the questions , compare your answers to those provided within this issue.
After completing the diagnostic process , @number@ patients were diagnosed extrinsic allergic alveolitis ( EAA ) and @number@ sarcoidosis.
After completion of the intervention participants could choose to continue performing RT unsupervised until 6-month follow-up.
After comprehensive geriatric assessment , the patients were divided into either sitagliptin or non-sitagliptin group.
After confounder adjustment , hazard ratios of @number@ and @number@ for CRC-specific survival were observed for Medicaid and uninsured.
After consensus review , the readers ' combined MRI sensitivity and specificity for sCJD was @percent@ and @percent@ , respectively.
After consensus was reached on content and scoring , item reduction began.
After consultations , their patients rated their involvement in decision-making processes ( SDM-Q-9 instrument ) .
After consulting the system-generated recommendations , a physician can alter prescriptions accordingly and report feedback , enabling the system to evolve with actual causal relationships.
After consumption , the majority of soy isoflavones are converted to their metabolites in the human gastrointestinal tract.
After controlling for age and baseline MADRS score , remitters exhibited lower CBF in the cACC and lower CVR in the cMFG.
After controlling for age , FA and MD were exclusively related to perceptual speed.
After controlling for age-related effects , both higher working memory and higher processing speed had a positive effect on all three learning parameters.
After controlling for age , TTR was negatively associated with log high-sensitivity CRP ( hsCRP ) and serum copper.
After controlling for all significant variables via bivariate analyses , the correlation between maximal occlusal force and cognitive function persisted.
After controlling for arthritis pain , persons with higher social support and higher cognitive functioning reported lower levels of depressive symptoms.
After controlling for background characteristics and physical and cognitive functioning , death-related decline was still found for SWB but not for subjective health.
After controlling for BMI , female subjects had greater levels of most inflammatory markers compared with male subjects.
After controlling for body mass index and gait speed , step width was significantly greater in the CLBP group during the fast walking condition.
After controlling for confounders , the AMS was significantly associated with aging , self-perceived health status and smoking.
After controlling for CPD and other covariates , there were no significant relationships between 30-day e-cigarette use and symptoms.
After controlling for current and nadir CD4 , AMH was ~15% higher in HIV-infected relative to uninfected women , regardless of HIV viraemia.
After controlling for exclusion criteria , @number@ subjects were included in the analysis.
After controlling for g within the bifactor model , some significant specific cognitive domain associations remained.
After controlling for multiple covariates , fatigability moderated the relationship between speed of processing and IL-6 reactivity.
After controlling for the differences across regions , the most powerful predictors of service provision were identified for both OT and PT.
After conventional endoscopy , the cause of anemia remains unknown in up to @percent@ of patients.
After correcting for age , QST indicated significantly greater somatosensory function in the HNP group compared with the LNP group.
After correcting for multiple testing none of the associations remained significant.
After correction for multiple comparisons , however , there were no significant differences.
After correction for multiple testing , no plausible loci were identified in the genome-wide analysis.
After correction for multiple testing , no statistically significant associations were found.
After correction for multiple testing , the left cuneus remained significantly associated with the interaction effect ( PFWE = @number@ ) .
After corrective or palliative operation in infancy or early childhood , some patients regularly need reoperations for right ventricular outflow tract reconstruction.
After covariate adjustment , main associations were not observed.
After day @number@ biopsies , participants consumed a D2O bolus ( @number@ ml , @number@ atom% ) ; saliva was collected daily.
After decades of ignorance and lack of public interest , old age has fundamentally been re-negotiated.
After deleting SHP2 , spermatogenesis was halted at the initial step during which transit-amplifying undifferentiated spermatogonia are produced from SSCs.
After demonstrating that antidepressants can stimulate neurogenesis in NHPs , our present study examines whether neurogenesis is required for antidepressant efficacy in NHPs.
After describing the defect , the authors present a surgical approach to rejuvenation of this region , tailored to the findings in this anatomical study.
After describing the definition and classification of lncRNAs , we present an overview of the mechanisms by which lncRNAs regulate gene expression.
After determining the pooled effect size , the effect of sample size on dichotomized effect sizes ( significant vs. non-significant ) was determined.
After development , caspases are downregulated in the nervous system , but continue to perform important nonapoptotic functions relevant for neurogenesis and synaptic plasticity.
After diagnosis , an anti-osteoporotic treatment is indicated to improve bone quality and bone healing.
After diagnosis of heart failure is established , a cause should be sought.
After diagnosis , they received additional antifungal therapy for @number@ - @number@ months , respectively , and the prognosis was good.
After direct age standardization , @percent@ ( @percent@ CI : @date@ @percent@ ) of participants in the four datasets were evening types.
After discharge , @number@ % of patients presented a new biliary complication , @number@ % of them severe.
After dissection , true lumen volume correlated to age.
After each list , the first word of one of the pairs was presented again and the listener was asked to recall the second word.
After edaravone intervening , ROS significantly decreased , HIF-1α and VEGF were downregulated , and cell proliferation declined.
After eliminating duplicate entries , the medical articles that remained were screened to narrow the sets of articles to those that met specific criteria.
After eliminating the effect of aging , the trend remained the same but the slope was decreasing.
After enrollment , all participants had optometric and ophthalmologic exams including slit lamp biomicroscopy and fundoscopy.
After entering the circulation , melatonin acts as an endocrine factor and a chemical messenger of light and darkness.
After entering the data , model output was analyzed by using the STATA software.
After etching , AdperSingleBond ( 3M ESPE ) adhesive was applied and the tooth was built up with a composite ( Filtek Z250 ) .
After etching , a @percent@ potassium oxalate gel was applied for @number@ seconds , except for the control group ( no desensitizer ) .
After ethnic stratification , 405V remained a risk allele in East Asians but no significant association was found in Europeans or white Americans.
After evaluation in the emergency department , @number@ patients ( @percent@ ) were hospitalized.
After excluding incident dementia cases , the association of IIVRT with mortality changed very little.
After excluding individuals with missing data , @number@ cases were included in the analyses.
After excluding multiple testing for an individual , a total of @number@ positive results were analysed.
After excluding @number@ duplicate titles , @number@ abstracts and @number@ full papers were reviewed.
After excluding @number@ patients with AA aneurysm , @number@ outpatients were enrolled.
After exclusion of incomplete or erroneous data , @number@ subjects were enrolled.
After exclusion of various diseases according to the study protocol @number@ athletes and @number@ controls could be selected for follow-up studies.
After exenteration , @number@ patients ( @percent@ ) were diagnosed with a recurrence of cancer , and the mean progression free survival was @number@ months.
After experiencing repeated thermocycling and being subjected to pH-cycling , the teeth were sectioned.
After exposure to OSCAR , the majority of the participants confirmed that changes had occurred in at least one of their abilities.
After exposure to PQ , both WT and KO cells showed an inflammatory and stress-related transcriptomic response.
After extended proliferation , cells enter a state of replicative quiescence that is probably due to progressive telomere shortening.
After external validation , wider adoption of this tool might enhance primary AO prevention.
After failure of clarithromycin-based triple therapy , followed by that of levofloxacin-based triple therapy , a bismuth-based quadruple scheme is an acceptable alternative.
After fMRI , recognition memory for the second word in each pair was evaluated outside of the scanner.
After following each protocol , SBS was determined using a universal testing machine , followed by failure mode analysis.
After full-article review , @number@ met inclusion criteria ; four additional articles identified in reference lists also met inclusion criteria.
After full text evaluation , @number@ of these were eliminated.
After full-text review , @number@ articles were included.
After further adjustment for other covariates , effect sizes were attenuated but most remained statistically significant.
After further neuropsychological testing and neurological examination , the diagnosis of dementia was confirmed according to DSM-IV criteria.
After gaining bladder control , behavior starts to be influenced by socialization.
After gender stratification , the association between obesity and short sleep duration was more robust in women.
After general consensus of the team was obtained , manuals and guidelines of the each division were prepared.
After GnRH agonist treatment , FM and %FM decreased for CA , but increased for BA.
After HD initiation , albumin variability decreased and reached a nadir within a year.
After highly extensive exclusion criteria applied to remove all samples that may have been taken from unhealthy people , @number@ samples remained.
After hip fracture , men were more likely than women to die from respiratory disease , malignant neoplasm , and circulatory disease.
After H₂O₂ treatment , intracellular calcium levels were highly elevated with a maximum concentration of @number@ nM.
After HUVEC exposed to Klotho protein , the induced function of VEGF expression was measured by Western blot analysis.
After image registration , standard and cortical morphological analyses were conducted.
After immersion for @number@ week , the liquid was analyzed for a range of elements with ICP-MS.
After implantation , tinnitus-related distress declined significantly for the group.
After incinerating the arteries with nitric acid and perchloric acid , the element content was determined by inductively coupled plasma-atomic emission spectrometry.
After incineration with nitric acid and perchloric acid , element contents were determined by inductively coupled plasma-atomic emission spectrometry.
After incubating for @number@ h , fibroblasts were harvested from the culture plates to test cell proliferation by flow cytometer.
After incubation and a gentle mechanical disruption step , MP networks could be collected with anatomical integrity.
After independent review of @number@ citations by @number@ authors , @number@ studies ( @number@ patients ) were identified as meeting the inclusion criteria.
After informed consent , cervicovaginal samples were collected and tested for HPV and C. trachomatis using polymerase chain reaction ( PCR ) .
After initial radiotherapy ( @number@ Gy / 4 Fr ) , she was subsequently treated with EP chemotherapy which achieved a partial response.
After insertion of the needle , the sutures were fixed to a small polypropylene mesh over the deep temporal fascia.
After intense scientific exploration and more than a decade of failed trials , Alzheimer's disease ( AD ) remains a fatal global epidemic.
After intervention , LV mass and end-diastolic volume increased and exercise capacity improved ( by ≈8% ) only in the exercise groups.
After intervention the mean score of quality of life only in experimental group significantly increased from @number@ to @number@
After investigating the family pedigree , we performed genetic and biochemical analysis on its members and performed RNA expression studies.
After laboratory and imaging studies , she was diagnosed with acute cholecystitis and cholelithiasis.
After learning list @number@ subjects receive either a forget or a remember list @number@ cue.
After learning , participants completed landmark free recall and distance estimation tasks.
After light aging , mixing method had no effect on ΔE of unpigmented specimens ( p > @number@ ) .
After lipid extraction , PL , CE , TG and NEFA were separated by thin layer chromatography and analysed by gas chromatography.
After liposuction , the fibrae septa and the cutaneous insertions of the mimetic muscles in the nasolabial region were severed by a sharp-edge eye scissors.
After losing peripheral vestibular function , some patients show better DVA performance than others , suggesting good compensatory mechanisms.
After losses , a sample of @number@ older adults was classified as non-frail , pre-frail and frail.
After MDMA treatment , tryptophan fiber density decreased and then recovered in all brain regions.
After multiple adjustments , miR-126-3p levels were seen to be lower in patients with poor glycemic control , compared with age-matched CTRs.
After multivariate adjustment , the opiate dose duration was independently predictive of RA ( P < @number@ ) .
After multivariate adjustment , TIMP-1 associated with E / E ' ( both at rest and stress ) and diastolic function reserve index.
After multivariate analysis , patients receiving / reading instructions showed higher-quality HBPM ( P < .01 ) .
After neuropsychological follow-up at @number@ months , participants were classified into cognitively stable controls and cognitively deteriorating controls.
After neutralization of FGF23 by anti-FGF23 administration , phosphaturia was still abundant , Klotho expression remained low , and the FGFR1 level was reduced.
After normalization and batch correction , several regression strategies were applied to evaluate associations between glycan patterns , familial longevity , and healthy aging.
After @number@.0±8.1 months , SDMT was also performed with a rearranged key in @number@ cases.
After @number@ days half of the samples were removed from the appliance.
After @number@ days pretreatment with CE ( @number@ mg / kg ) rats were subjected to @number@ min. transient global cerebral ischemia.
After @number@ days , the results were more variable and gave unreliable estimates of time since deposition.
After @number@ d of aging , @number@.5-cm-thick steaks were cut , consecutively cut steaks were paired for consumer evaluation.
After @number@ duplicates were removed , @number@ publications underwent title and abstract review , yielding @number@ articles for full-text review.
After @number@ h incubation with HG / HM , we observed a significant similar and concentration-dependent enhancement of AQP1 expression.
After @number@ h of fasting , volunteers received a breakfast reflecting the fatty acid composition of the diet ingested in the preceding dietary period.
After @number@ hours , there was a higher secretion of inflammatory cytokines IL-1β and IL-8.
After @number@ million test cycles no structural failure of the gliding components was observed.
After @number@ month , FWS score at rest was approximately @percent@ lower for BoNTA , versus @percent@ lower for BTXCo.
After @number@ month , @percent@ of patients had IOP values beyond @number@ mmHg , while @percent@ after @number@ year.
After @number@ months , a further neuropsychological assessment showed a progression in cognitive deficits , with additional attention deficits.
After @number@ months and @number@ yr , the control group demonstrated significantly lower μTBS than all treatment groups.
After @number@ months , a volume gain was found in all patients.
After @number@ months , coaches participated in a \ "booster \ " session that included videos of ideal coaching practices.
After @number@ months , FWS reduction was approximately @percent@.
After @number@ months , MMSE improvement was associated with a significant decrease in β2M ( p = @number@ ) .
After @number@ months , @number@ patients were re-examined.
After @number@ months , objective and subjective criteria were recorded , photos were taken for documentation and the WSRS scale system was used.
After @number@ months of follow-up , no other patients showed any recurrence.
After @number@ months of follow-up , there was a memantine-related improvement of the MMSE score only in the participants with VDD-M6.
After @number@ months , patients with hemoglobin A1c ( HbA1c ) ≤7.0 % advanced to the 24-month maintenance phase.
After @number@ or @number@ weeks of irradiation , neutrophils were investigated by light microscopy and transmission electron microscopy.
After @number@ training sessions , muscle strength also significantly increased ( P < 0.0001 ; 40%-80% ) in both groups.
After @number@ week , all participants watched a second event and freely recalled its content.
After @number@ weeks , cognitive and noncognitive components of behavior were determined.
After @number@ weeks GA , it disappeared and turned into mature-like structures.
After @number@ weeks , intervention group participants performed significantly better than controls on the TUG.
After @number@ weeks of aging with artificial saliva , all materials were significantly cytotoxic when compared to the control group.
After @number@ weeks of balance exercises , mean MXEcomp improved ( p < @number@ ) from @percent@ to @percent@ in the exercise group.
After @number@ weeks of follow-up treatment , a statistically significantly higher skin elasticity level was determined in elderly women.
After @number@ weeks of intervention , there was no significant difference in either metabolic or inflammatory parameters between the @number@ groups.
After @number@ weeks of treatment , melatonin given orally increased skin sebum , moisture and elasticity levels , and melatonin applied topically increased sebum level.
After @number@ weeks , oxidation of the low-density lipoprotein fraction was markedly reduced accompanied by decreased apolipoprotein B ( apoB ) fragmentation.
After @number@ weeks , the minoxidil group achieved significantly better results in all measured outcomes compared to the placebo group.
After @number@ weeks , there were statistically significant increases in PERFECT scheme , Brink scale , perineometry , and ultrasound values.
After @number@ weeks , the survival rate was @percent@ ( @percent@ CI , 59%-70% ) and was not significantly different between Candida spp.
After @number@ weeks treatment , mirodenafil was found to be more effective than placebo , and tolerability was good.
After @number@ weeks , two patients showed an amelioration of intima media thickness.
After @number@ weeks , while the silhouette slimmed down , metabolic parameters were significantly improved and general satisfaction considerably ameliorated.
After @number@ wk , multiple dentin / root resorption lacunae were present in root dentin with robust RANKL and OPG expression.
After @number@ year , her depression resolved but she developed a dry cough.
After @number@ year of bottle aging , CS wines retained @percent@ more anthocyanins than control wines , but tannins and total phenolics remained unaffected.
After @number@ year of follow-up , @number@ of @number@ patients met the criteria for probable DLB.
After @number@ years , AL was prospectively associated with depressive symptoms , but entering age and sex as covariates attenuated this effect to a trend.
After @number@ years , both exposures predicted both types of MSDs among men.
After @number@ years , @number@ % of the eyes showed a progression of at least @number@ unit in the DSS.
After @number@ years , @number@ participants had died , @number@ had developed CVD , and @number@ had developed HF.
After @number@ years , @number@ participants were re-examined.
After @number@ years of age , attention abilities were impaired.
After @number@ years of age , however , the zG occupied less than one-quarter of the adrenal circumference , suggestive of zG involution.
After @number@ years of development of Hospital Medicine in Chile , there are several benefits of this discipline.
After @number@ years of follow-up , @percent@ of the patients had died.
After @number@ years , persons with mild subclinical hypothyroidism experienced a similar decline as the euthyroid group but maintained their mobility advantage.
After @number@ years , RBM thickness decreased with increasing age ( r = -0.42 , p < 0.05 ) .
After @number@ years remaining @number@ people were re-examined.
After obtaining ethical approval and informed consent surveys were conducted in a total of @number@ participants ( n = @number@ for each group ) .
After one year of follow-up , @number@ ( @percent@ ) participants had died.
After only limited training @number@ of @number@ younger adults and @number@ of @number@ older adults showed performance consistent with highly efficient processing.
After optic nerve or spinal cord injury , inflammatory stimulation and / or modification greatly improve the regenerative outcome in rodents.
After optimizing flow cytometric analysis , these dual-fluorescence cell-based biosensors were capable of accurately and rapidly detecting NP toxicity.
After oral administration , anthocyanins can pass through blood-brain barrier and thus appear in various organs and brain.
After oral administration of a tablet containing @number@ mg LD per @number@ mg carbidopa in @number@ PD patients , we measured plasma LD concentrations.
After ordinary dissections by students at Chiang Mai University were finished , the left coronary arteries were resected from Thai subjects.
After participants completed the questionnaires , we conducted individual semi-structured cognitive interviews using verbal probing.
After percutaneous biopsy , preoperative cytopathological examination of the large mass revealed dedifferentiated chondrosarcoma.
After performing logistical regression analysis to control demographic variables , we found that QoL and ADL were critical for predicting MCI.
After pilot testing , items with minimal variability were eliminated.
After PIPC TAZ administration , PIPC concentrations in plasma were measured chromatographically and the pharmacokinetic parameters were estimated.
After pointing completion to the first target , the older adults maintained their gaze fixation to that target for a longer duration than young adults.
After posttreatment for @number@ months , significant improvement was observed compared with the baseline.
After preparation of the lesion and within @number@ min after MAL application , patients expose themselves to daylight for @number@ h.
After primary PCI , CAVB was reversed in all patients.
After prolonged DAC treatment , phosphatidyl serine exposure , nuclear morphology analysis , and caspase cleavage revealed an activation of mitochondrial-dependent apoptosis in CML cells.
After quality assessment , meta-analysis and meta-regression were performed to generate random effect size using standardized mean difference ( SMD ) .
After random assignment to experimental or waiting-list control groups , participants were given pre- and posttests on both functional and cognitive measures.
After randomization , women were divided into two groups : @number@ receiving STC and @number@ receiving conventional counselling.
After reaching adulthood , orderly repair is probably one of the most important mechanisms throughout lifetime.
After re-adaptation , we assessed aftereffects of this pattern during conventional treadmill walking.
After reading the @number@ final articles in their entirety , two additional articles , found by a manual search , were included.
After reading this article , the reader should also be able to : @number@
After recognition completion , participants were asked to identify all odors by means of free or cued identification.
After resection , the chest wall defect was reconstructed using polypropylene mesh and a transverse rectus abdominis myocutaneous flap.
After reviewing and integrating current theories about retirement adjustment , we propose a resource-based dynamic perspective to apply to the understanding of retirement adjustment.
After reviewing , @number@ articles were included.
After reviewing the literature on mortality modeling , we found that different chronic processes underlie mortality before and after reproductive age.
After saturated fat diet consumption , phenylacetylglycine excretion was inversely related to CoQ plasma level and positively correlated with isoprostanes urinary level.
After scanning , free recall performance was assessed.
After scavenging debris , they can digest cellular proteins into smaller pieces , and protein-derived peptides can subsequently be presented to the immune system.
After SCI , the elderly have a higher risk for late hemodynamic instability.
After screening and de-duplication , @number@ studies that used SRT with the population of interest remained.
After selecting an iRR segment ( @number@ min ) with the smallest variance , an auto regressive model was used to estimate the PSD.
After sequence optimization , validation and sensitivity measurements were performed in muscle phantoms ex vivo and in vivo.
After setup , @number@ inpatients and @number@ outpatients with stroke and stroke mimics were treated.
After seven days of treatment , mechanical testing of the constructs was performed.
After SHS aging for @number@ h , 13-18% of the initial ROS mass remained , suggesting the presence of persistent ROS.
After signals are generated , olfactory information is processed and coded in the olfactory bulb and disseminated to several areas in the brain.
After six months of treatment the reevaluation shows a statistically significant reduction of the pathological parameters although without achieving tensional control.
After six months the patients were reassessed.
After six weeks ( expiration date ) , intracellular glutathione was reduced by @percent@ , reflecting increasing oxidative stress.
After six weeks , participant satisfaction with the educational videos was assessed.
After smoking adjustment the linear trend was borderline statistically significant ( p trend = @number@ ) .
After SNP quality controls , @number@ SNPs remained for analysis.
After software-aided aging , the images evoked strong emotions , especially in subjects with an advanced motivational stage to quit.
After some decades of struggle , geriatrics and gerontology have become the legitimate sciences of aging.
After standardization , the highest rates of hip fracture were found in Scandinavia and the lowest rates in Africa.
After starting anticoagulation , the 3-year survival in @number@ patients with baseline MPAP < 33mmHg was @percent@.
After stimulation , NK cells of both old groups showed higher intracellular levels of IFNγ than young subjects.
After stimulation with ConA , cells are not restored to the previous telomere length and undergo replicative senescence.
After stopping treatment , reductions in BMD are expected to occur long before mean tissue age returns to normal.
After storage , the teeth were placed in @percent@ methylene blue dye for @number@ hours , sectioned , and evaluated under a 20× stereomicroscope.
After stratification by APOE ε4-carrying status , significance was observed in APOE ε4 non-carriers for rs116806486 and in APOE ε4 carriers for rs6691117.
After stratification by sex , the results were confirmed in women only.
After stratifying by gender and age , this effect remained significant among females and young elders ≤80 years.
After stratifying by HCV status , those with evidence of advanced liver fibrosis were equally likely to be exposed to acetaminophen.
After stroke , independence declined at an annual rate similar to those who did not have stroke.
After studying the pairs , participants were shown each item and asked to recall the associated price.
After subtraction of bone volumes from the scans , LLACs were detected and contoured by a semi-automated , dual-threshold seed-point segmentation.
After surgery , gastric submucosal arteries were immediately dissected free of fat and connective tissue.
After surgery , sleep disturbance improves to levels comparable with those of the general public.
After surgery , the subjects were divided on the basis of delirium onset within a week observation period.
After surgical treatment , we distinguish two groups basing on local nasal therapy.
After tailored testing with CAT , the remaining CAMCOG and CAMCOG-Plus items not selected by CAT were administered.
After TCML , all specimens were examined with microscopy and scanning electron microscopy.
After TCML of artificial teeth , direct and preformed composite veneers on composite teeth showed no failures or damages.
After ten minutes of sham or active tDCS , participants performed verbal and visual WM training tasks.
After testing , each specimen was subjected to wide-angle X-ray scattering ( WAXS ) measurements of its collagen organization.
After testing , the collagen fiber structure was mapped using wide-angle X-ray scattering.
After testing the intact meniscal state , a horizontal cleavage tear was created and included @percent@ of the width of the meniscus.
After that , a clearing technique was performed to illustrate root canal anatomy.
After that , however , there is an increase in amyloid levels in plasma among females and a decrease among males.
After that , participants completed the Self-Construal Scale.
After the 5-day intensive yoga training program , the menopausal women practiced yoga daily at home for 35-40 minutes a day.
After the 8-week resistance training , TLR2 and TLR4 protein expression was reduced in TG.
After the account , spouses described their distress.
After the age of forty , the recurrence rate does not differ according to the use of postoperative medication.
After the age of @number@ cycle-to-cycle adaptive coordination based on visual information was progressively acquired leading to increasing performance levels with age.
After the age of @number@ more than @percent@ of the patients had an E / e ratio superior than @number@
After the baseline investigation we performed three follow-up investigations at @number@ months intervals with incident dementia as the primary outcome.
After the Cancer Control Act in @number@ the Act on Promotion of Cancer Registries was finally enacted in Japan on @date@ .
After the delay period , details about the election were better remembered by all participants than a less emotionally arousing comparison event.
After the exercise program all participants were reevaluated.
After the experimental period , the microtensile test was performed.
After the experiment , the results of the system evaluation revealed excellent agreement between the text-based and multimedia version of Taipei II.
After the experiment , the subjects indicated that the developmental delay e-screening system increased their comprehension and kept them interested in the screening.
After the final word pair , the participants were cued with the first word of one of the previous five word pairs.
After the first 15- second time interval , the demented groups produced significantly fewer exemplars than the non-demented.
After the fourth treatment , angiogenesis and increased collagen fibers were observed in the dermal papillary layers of both arms.
After the hypnotic suggestion , we observed a @percent@ increase in SWS in females suggestible to hypnosis as compared to the control condition.
After the initiation of insulin therapy , physical activity decreased significantly , but this did not determine weight gain over the first @number@ months.
After the intervention , both groups completed the Patient Satisfaction Questionnaire.
After the intervention , knee-extension strength was maintained in AG and LG.
After the intervention period both groups demonstrated improvements in muscle strength , body composition , and thigh composition.
After the intervention , the intervention group exhibited better HRQoL than the control group at each of the measurement phases.
After the last training session , an increase in IGF-1 / IGFBP-3 and attenuation in ammonia levels were suggestive of lower muscle protein catabolism.
After the manipulation , the Simon task was performed again.
After the numbers on the circles on the screen had disappeared , the subjects were required to indicate the circles in ascending order.
After the Patient Protection and Affordable Care Act is fully implemented , Medicaid will be the largest single health care payer in the United States.
After the patient underwent auto bone marrow mononuclear cells transplantations twice , the patient's symptoms were alleviated.
After the presentation of the Set1 items , participants were instructed either to forget or to continue remembering the source of the items.
After the primary examination , the participants of the study were randomly divided into two groups.
After therapy discontinuation , the beneficial effects progressively decreased , but were still detectable after @number@ months.
After the retirement transition , sleep duration remained at approximately the same level , as no significant changes were observed.
After the second exposure they were instructed to stay inside for the remainder of the @number@ hour post treatment period.
After the second magnetic resonance imaging , occurrence of death was recorded during @number@ years of follow-up.
After these treatments , her heart rate increased and we did not detect TdP again.
After the stimulation , we recorded their neural activity using EEG while the participants solved small and large arithmetic problems.
After the study , participants were grouped based on whether they were able to accurately follow the instructions provided by the navigation system.
After the surgery , mean monosyllabic word recognition reached @percent@.
After the surgery , she developed tetraplegia.
After the transition period , the follow up is referred to the person's home district.
After the visit to the IMPACT clinic , Mr K's care was returned to his regular family physician.
After this , normal glycemia was maintained for the following @number@ h.
After this , sex difference progressively increased with advancing age.
After three monthly injections , patients were examined monthly , and subsequent injections were performed as needed.
After three months , @percent@ of patients would recommend the procedure to others , an increase from @percent@ after one month.
After three months , the exercise program had become a regular home exercise habit for @percent@ of the subjects.
After three months , the RCG responded to a mail questionnaire.
After TLR7 stimulation , CD11c increases in all B cell subsets ( especially in naïve and IgM ) from the elderly.
After training on a texture discrimination task for three daily sessions , both older and younger subjects show performance improvements.
After transfer , GHD persisted in @number@ patients and four of the @number@ resolutive GHD were non idiopathic.
After treatment , an improvement in balance performance was observed in the intervention group.
After treatment , serum from such women showed reduced both lipidic peroxidation and oxidized low-density lipoprotein ( LDL ) .
After treatment , the improvement rates in the IIEF-EF , EHS , and IIEF Q13 scores were @percent@ , @percent@ , and @percent@ , respectively.
After two weeks , training exercise therapy was done in patients.
After two years , @number@ subjects were hospitalized for @number@ hospitalizations.
After validation , the model was used to estimate how age-related changes in vitreous physiology and structure alter oxygen levels at the lens.
After validation with their primary care physicians , @number@ patients were confirmed as having incident chronic AF and @number@ as having paroxysmal AF.
After viewing each picture , participants could allocate hypothetical points to either the offender or the victim in a dictator game.
After vitro fertilization of oocyte retrieved , four early embryos were derived.
Afterward , all participants were presented with the Set2 items , and were asked to remember their source.
Afterward , participants wore the activity monitor for seven consecutive days.
Afterwards , a peripheral target was illuminated.
Afterwards , a semi-structured interview was undertaken.
Afterwards their memory performance was measured using a standardized memory test ( Rey's Auditory Verbal Learning Test ) .
Afterwards , they were immersed in basic fuchsin solution for @number@ h and bucco-lingual sections were obtained from each tooth.
Afterward , subjects received an interference task ( watched a movie ) for @number@ min.
Afterward , the sources ' ages-23 and @number@ years-were revealed and participants completed a source-monitoring task requiring attribution of statements to the sources.
Afterward , they were exposed to experimentally induced pain.
After wear testing , some samples were subjected to accelerated aging and then wear-tested again.
After which the interviewees were asked to evaluate this service , comprising the interview and written advice.
After wounding of skin samples or removal of the stratum corneum , infected cells were rarely detected.
After WS , the self-etch adhesive showed higher μTBS than did the etchand- rinse adhesive.
After years of linear gains in the genetic dissection of human disease we are now in a period of exponential discovery.
After years of research , is has become increasingly accepted that age has a negative effect on mitochondrial bioenergetics.
A full-crown retainer was used as a control.
A full description of @number@ falls was obtained during the follow-up period.
A full understanding of BACE biology in health and disease is needed to establish a safe AD therapy based on BACE inhibitors.
A fully automated segmentation pipeline estimated volumes of the MTL and BG from whole-brain magnetic resonance imaging performed at baseline and @number@ years later.
A fully functional UPP is required to execute most stages of lens differentiation , specifically removal of cell nuclei.
A. fumigatus was positive from sputum cultures.
A functional chronic hypercortisolism could be established , enhancing PHPT related disorders.
A functionality assessment tool and a Visual Analogue Scale were applied , and social and demographic issues were also considered.
A fundamental issue in the interpretation of chest CT lies in the ability to determine normality.
A fundamental process in the onset of RA is the breakdown in self-tolerance.
A further aim was to compare this water-based protocol with a land-based protocol and a control group.
A further development of the MCI concept and its operationalisation is necessary.
A further finding was that the reaction time data and the N1 wave amplitude information hardly yield any correlate of the invested listening effort.
A further goal was to investigate the relationship between working memory and cognitive efficiency measures and cognitive failures.
A further increase in the total burden of the live-in caregivers was noticed at the 6-month follow-up.
A further intervention study is required to evaluate whether reducing anticholinergic burden might improve cognitive function among older adults.
A further @number@ g BLT was applied for another @number@ minutes.
A further @number@ instruments were partly supported by content and / or structural and / or criterion validity and / or hypotheses-testing evidence.
A further @number@ patients commenced dialysis during this period without attending either clinic.
A further \ "One-stitch \ " of anchorage to the deep temporal fascia is required to hold tissues.
A further third self-reported they had been told by a health professional they had hypertension.
A further two reviewers assessed the methodological quality against agreed criteria.
A future challenge would be the clinical implementation of aerobic training and methods to increase feasibility in this patient group.
AF was defined from medical records.
AF was detected an average of @number@ ± @time@ earlier in HM patients than on routine clinical visits alone.
AF was determined using study visit electrocardiograms , death certificates , and hospital discharge records.
AF was identified by using diagnostic codes.
AG11 prevented polymerization of purified tubulin in a concentration-dependent manner in vitro and disrupted mitotic spindle formation in cells.
A G2 / M arrest was observed for RKO and HCT-116 cells , and G1 arrest for HT-29 colorectal cancer cells for combinatorial treatment.
A ( G4C2 ) n repeat expansion in C9ORF72 is the most common genetic cause of ALS and frontotemporal dementia ( FTD ) .
AGA , due to dihydrotesterone , is treated by 5-α reductase inhibitors , androgen receptor blockers and ATP-sensitive potassium channel-openers.
Again , aiming duration accounted for the variance in the data.
A gain and loss of AR function enhanced and repressed ESCC cell growth , respectively , by altering cell cycle progression.
Again , an N400 effect ( 300-600 ms ) differentiated between visually and auditorily learned names.
Again , for older adults , the higher the incremental endorsement , the better the free recall.
Against accelerated and real-time aging in vitro , this material showed superior oxidation resistance to UHMWPEs with residual free radicals.
Against pandemic influenza A ( H1N1 ) @number@ anti-influenza drugs were useful to save the disease aggravation and reduce the mortality.
Against the background of an aging workforce , the investigation of the interconnection of mental fatigue and aging is of great practical relevance.
Against these predicted walking speeds , standard crossing times appeared insufficient for very old people.
Against this backdrop , we review advances in sensing labile copper pools and understanding their functions using synthetic fluorescent indicators.
Again , the less pronounced increase was observed in the groups of respiratory diseases , musculoskeletal , infectious diseases and injuries.
Again , the risk of functional impairment at time @number@ was a gradient effect , extending into the normal range of baseline 3MS score.
Again this contrasts with the asthma prevalence among adults , which is highest in high-income regions.
AG and LG followed a 6-month , twice-weekly , multimodality exercise intervention.
A ganglion was detected by pCLE in @number@ cases ( @date@ , @percent@ ) .
Age > 60 years at diagnosis and treatment before @number@ were correlated with decreased survival on both the univariate and the multivariate analyses.
Age ≥65-years-old and impaired functional status are the only patient characteristics that are independently associated with increased risk of recurrence.
Age≥75 years alone yielded an AUC range of @number@.56-0.57 and identified @percent@ at increased risk in the validation cohort.
Age accelerates pathology-related decline.
Age-adapted survival was similar for four trials , but differences up to @percent@ were seen in most.
Age added independent variance at @number@ of the @number@ sites , while alcoholism and sex added independent variance at frontal sites only.
Age-adjusted 5-year relative survival was higher in women ( @percent@ vs. @percent@ , P < 0.0001 ) .
Age-adjusted analysis revealed that hs-CRP and IPSS were the independent factors affecting SHIM score ( r = @number@ and @number@ respectively ) .
Age-adjusted cancer incidence among individuals without HIV increased @percent@ per year ( @percent@ CI @number@ to @percent@ ) .
Age-adjusted cancer incidence decreased in the HIV infected population by @percent@ per year ( @percent@ CI @number@ to @percent@ ) .
Age-adjusted incidence rates for the Netherlands were calculated using national age-specific population figures.
Age-adjusted linear regression analysis showed a significant inverse association between PWV and cCSA , in women but not in men.
Age-adjusted LTL was positively associated with IGF-1 level throughout the age range of the cohort ( r = 0.270 , P < 0.001 ) .
Age-adjusted maximal heart rate was calculated using prediction equations based on leg exercise and compared with measured HRMAX data for the arms.
Age-adjusted multiple logistic regressions were performed with original and imputed datasets.
Age-adjusted Pearson correlations were used to examine the relationship between average steps per day and age and anthropometric variables.
Age-adjusted SCC incidence and mortality rates and 5-year relative survival ( in percent ) were calculated for 5-year calendar periods.
Age-adjusted sleep ( deviation from that predicted by age ) was computed.
Age , admission Glasgow Coma Scale , intraventricular extension , and END were independently associated with poor outcome.
Age , ADT , history of hypertension , and the natural decline in EF have negative impact on long-term EF after PB.
Age advantages are most pronounced when people recall emotions across increasingly longer periods of time.
Age affected cerebellar mass in men ( R = @number@ ) more , than in women ( R = @number@ ) .
Age affects cognitive control.
Age affects different levels of the clock machinery from molecular rhythms , intracellular messenger , and membrane properties to neuronal network synchronization.
Age affects mortality from all diseases differently than it affects mortality from external causes.
Age affects mortality rates from all diseases differently than it affects mortality rates from nonbiological causes.
Age affects the human taste system at peripheral and central levels.
Age affects the immune response to vaccination , with individuals at the extremes of age responding poorly.
Age , albumin , testosterone concentration and metabolic parameters were considered as confounding factors.
Age alone has not been an absolute contraindication to a life-sustaining organ transplant for several decades.
Age alone has not to be considered as exclusion criteria for robotic approach.
Age alone should not preclude elective craniotomy.
Age also had a significant effect on the rates of clinical pregnancy , live birth and multiple pregnancies ( p < @number@ ) .
Age also significantly affects circulating testosterone concentrations.
Age and APOE are the most robust risk factors for dementia and cognitive decline , but the underlying neurobiology remains unclear.
Age and APOEɛ4 carriage were used as covariates for all analysis.
Age and audiometric configuration did not correlate to performance in the RDGT and in the SAC.
Age and BMI-adjusted effect estimates from the MR analysis confirmed the inverse association between GMV and WHR and are in favor of a causal association.
Age and BMI were found to be significantly associated with the degree of paraspinal muscle changes over time.
Age and Brain interconnected in a number of ways.
Age- and cohort-matching was done between @number@ untreated subjects with WCH and @number@ normotensive control subjects.
Age and COL5A1 BstUI genotype interacted significantly for SR ROM.
Age and comorbidity may hamper the use of the most active treatment regimen , such as high dose cytarabine and autologous stem cell transplantation.
Age and CSF glucose levels influenced CSF lactate levels even after adjusting for gender , age , CSF protein levels , and CSF glucose levels.
Age and duration of HIV diagnosis were not associated with physical and global functioning.
Age and dyslipidemia were independent negative predictors of TL.
Age and education-adjusted expected scores were computed using @number@ matched stroke-free controls.
Age- and education-adjusted scores are provided by applying linear regression techniques.
Age and educational level may influence the performance in determining the meaning of pictograms.
Age and education contributed , both directly and indirectly through knowledge , to explain fish consumption behaviour.
Age and education were found to be associated with the total score on the test , while gender was not.
Age and fat-free mass were included as covariates.
Age and gender differences emerged regarding reminiscence functions.
Age and gender differences were minimal.
Age and gender effects on valence and arousal ratings were statistically significant but weak.
Age and gender influenced reaction times of both volunteers and patients with cirrhosis.
Age- and gender-matched controls were also assessed.
Age and gender partitions were statistically determined , outliers removed and reference intervals calculated using CSLI C28-A3 guidelines.
Age- and gender-related differences should receive attention.
Age- and gender-specific differences found in trends of ov / ob prevalence may help optimise preventive and therapeutic measures.
Age- and gender-specific population projections were retrieved until @number@ from the Eurostat online database ( @number@ European countries ) .
Age- and gender-specific z-scores for BMI were obtained from height and weight at the ages of @number@ @number@ @number@ and @number@ years.
Age- and gender-stratified time trend analyses showed consistent patterns.
Age and global brain atrophy were the most important variables in explaining variability in hippocampal volume.
Age and hearing loss interacted with rate with smallest group differences observed at the lowest and highest interruption rates of @number@ and @number@ Hz.
Age and hearing thresholds were modeled as continuous predictors with corrections for correlations among multiple measurements of the same participants.
Age and hypertension were independent risk factors for MBs.
Age and low educational level were associated with lower EQ VAS and PCS scores.
Age- and non-argyrophilic grains ( AGs ) degeneration matched controls were selected for each case.
Age and other established fall risk factors were not associated with responses on either fall risk awareness question.
Age and other vascular risk factors were also investigated.
Age- and pain-related ADL reference values were plotted and confirmed that disability increased with increasing age.
Age and percentage of the cochlear volume receiving @number@ Gy or greater were found to be statistically significant predictor variables.
Age and preoperative spherical equivalent were recorded for all patients.
Age and quality of dietary control before or between subsequent examinations showed an independent cumulative effect on white matter alterations outcome.
Age and renal function appear to affect the exposure of dabigatran etexilate.
Age and SBP are the main longitudinal determinants of PWV , and the effect of SBP on PWV trajectories exists even in the prehypertensive range.
Age and sex differences in acute response to LPS are discussed as possible mechanisms of vulnerability to adverse effects.
Age- and sex-matched controls were drawn from the general population via the Civil Registration System.
Age and sex may moderate the relationships between depressive symptoms and WMLs.
Age and sex of the targeted participants may also need to be considered when developing interventions.
Age- and sex-specific curves of muscle mass , strength , and function , using data from a large sample of community-dwelling people , are necessary.
Age- and sex-specific dementia prevalence was calculated.
Age- and sex-specific incidence rates were calculated using the total diabetes population in England every year.
Age- and sex-specific prevalence / utilization estimates for musculoskeletal disorders were calculated.
Age- and sex-standardized prevalence of HF was @percent@ in @number@ @percent@ in @number@ and @percent@ in @number@
Age- and smoking-adjusted genotype-phenotype associations were estimated in regression models.
Age and systolic blood pressure ( SBP ) were independently associated with calcification progression in all vascular beds.
Age and systolic blood pressure were the dominant risk factors for IHD in this group.
Age and the EHRA score permitted higher levels of frailty syndrome to be predicted.
Age and weight were not significantly correlated with PR ( p > 0.05 ) .
Age and wheelchair use were significantly , negatively associated with total LTPA.
Age appears to be an independent predictor of prognosis rather than a marker for comorbidity.
Age-appropriate testing mode can improve detection of osteoporotic fracture risk in early menopause by determining muscular strength reduction related to BMD loss.
AGE are not only formed within our bodies but are also derived from foods , endowing them with flavor.
Age , arterial hypertension and an elevated BMI level are significantly associated with an increased WLR.
Age-associated alterations in the mucosal immune system are generally termed mucosal immunosenescence.
Age-associated cardiovascular diseases are at least partially ascribable to vascular cell senescence.
Age-associated changes in brain elements warrant further investigation.
Age-associated changes in NK cell phenotype have been previously reported that can be responsible of functional NK cell deficiency.
Age-associated changes in the structure and function of the lung may increase a pathogenetic susceptibility to COPD.
Age-associated , chronic low-grade inflammation augments the susceptibility and severity of pneumonia in the elderly.
Age-associated decline in muscle function represents a significant public health burden.
Age-associated decline in organ function governs life span.
Age associated decline of the immune system continues to be a major health concern.
Age-associated dementia and Alzheimer's disease ( AD ) are currently epidemic.
Age-associated DNA methylation changes are counteracted in iPSCs.
Age-associated DNA methylation changes were related in fibroblasts and MSC but they were often regulated in opposite directions between the two cell types.
Age-associated dysregulated immune and inflammatory responses are one of the major factors responsible for the prevalence of chronic respiratory diseases in the older population.
Age-associated increases in DNAm target developmental genes , overlapping those associated with environmental disease risk factors and with disease itself , notably cancer.
Age-associated olfactory loss is often multifactorial and requires careful history and physical exam.
Age-associated physical musculoskeletal alterations increase elder adults ' ( age @number@ and older ) risk for injury.
Age-associated reduction in ankle proprioception was confirmed from two subtests of threshold and tracking separately for women and men.
Age-associated reductions in sex steroids also provide insight into apparent temporal increases in susceptibility to periodontitis and alveolar bone loss , particularly among women.
Age-associated risk for metabolic syndrome was significant only for adults with high anger expression.
Age-associated ventriculomegaly is typically attributed to neurodegeneration ; however , additional factors might initiate or contribute to progressive ventricular expansion.
Age-associated white matter degeneration has been well documented and is likely an important mechanism contributing to cognitive decline in older adults.
Age association with lesion classification was analyzed using random effects Tobit regression , adjusting for intracranial volume ( ICV ) and risk factors.
Age at AR was calculated from changes in weight and height velocity over time.
Age at first offense predicted best.
Age at initial diagnosis also differed , with women presenting between ages 60 69 years and men presenting between ages 70 79 years.
Age at menopause , baseline age , body weight and FSH were independent predictors of bone loss.
Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer , cardiovascular and bone disorders.
Age at onset of progressive biomarker changes that distinguish carriers from noncarriers was estimated using best-fitting regression models.
Age at onset ranged from @number@ to @number@ years ( mean [ SD ] age , @number@ [ @number@ ] years ) .
Age at onset was not associated with cognition independent of duration.
Age at Tanner pubertal stage was determined and regression analyses were used to explore associations between prodromal symptoms and age at puberty.
Age at the time of SCI was significantly associated with motor FIM ( F1 , 238 = @time@ , P < .001 ) .
Age-based comparison between CTRs and T2DM demonstrated significantly different miR-126-3p levels only in the oldest ( @number@.48±0.39 vs. @number@.22±0.23 , p < 0.005 ) .
Age-based regression equations and per-year reductions in all variables significantly related to age are reported.
Age , body mass index , and smoking were associated with anemia.
Age , body mass index ( BMI ) , and serum prostate-specific antigen ( PSA ) level were found to be significant predictors of PV.
Age , but not education , constitutes a major determinant of these symptoms.
Age-by-A / D and sex-by-A / D interactions were not associated with amygdalar or hippocampal volume.
Age-by-A / D and sex-by-A / D interactions were tested.
AgeCGs are significantly associated with poorly expressed genes , but those with decreasing methylation are linked with higher tissue-specific expression levels compared with increasing methylation.
Age changes affect the oral mucosa ( the protective lining of the oral cavity ) , but few of these have been studied objectively.
Age , cognitive and functional status , previous history of delirium and hypotensive episodes intrasurgery are the best predictor of POD in this setting.
Age-comparison showed that elderly subjects had high agonist preactivation but thereafter lower activation during the braking phase.
Age continued to be significantly associated , whereas sex remained only associated with the ESR level.
Age control blood samples were collected from @number@ neonates and @number@ healthy female volunteers.
Age-corrected FEV1 / FVC threshold underdiagnosed COPD in @percent@ while fixed threshold overdiagnosed spirometric obstruction in @percent@.
Age-correction factors for GI-V were determined using linear regression analysis.
Age-correlated decreases of functional connectivity and increases of BOLD signal variability were associated with multisensory vestibular networks.
Age-correlated dermal fibroblast quantity is established.
Age correlated negatively with callosal area in the control group but not in the bipolar group.
Age correlated negatively with T , while a negative correlation was observed between TIPSS and 3β-diol and AKRIC1.
Age correlated positively with thyroid volume ( r = 0.31 , p < @number@ ) .
Age correlated stronger with baseline erosion-scores compared to joint space narrowing ( JSN ) -scores ( r = 0.38 versus @number@ ) .
Age correlated with cortical thinning in controls but not in LLD.
Age correlated with influenza antibody responses , but not with IFNγ or IL-10 production.
AGE cross-links ( pentosidine ) of the patellar tendon were measured biochemically , and in the skin , it was assessed by a fluorometric method.
Aged animals show a more severe phenotype in cellular division , consistent with progression of cardiovascular complications seen in older ADPKD patients.
Aged dermal fibroblasts were minimally affected by inhibition of autophagic activity.
Aged dermis , in fact , has a degenerated collagen matrix.
Aged dogs are known to suffer from cognitive dysfunction and this state is associated with deposition of Aβ in the brain.
Age dedifferentiation effects may therefore reflect dementia and other mortality-related pathology rather than being an inevitable outcome of advanced age.
Age , denture use , socioeconomic status , health status , and health behavior were adjusted.
Age dependency is more pronounced.
Age-dependent cancer incidence thus has been explained in terms of the time necessary for oncogenic mutations to occur.
Age-dependent changes in humans and rodents are discussed in relation to rodent models of disease.
Age-dependent changes in the cellular immune response have been mainly described in CD8 + T cells , with relative sparing of CD4 + T cells.
Age-dependent collapse of lipid homeostasis results in spillover of lipids and excessive fat deposition in nonadipose tissues.
Age-dependent comorbidities , such as hearing disorders , are more prevalent and affect the quality of life in a noticeable manner.
Age-dependent decline in skeletal muscle function leads to several inherited and acquired muscular disorders in elderly individuals.
Age-dependent decrease in the content of angiomotin in blood vessels of the dermis was detected.
Age-dependent decreases in the total osteocyte lacunar number were measured in all of the cases.
Age-dependent diagnostic cutoffs for normal sonographic diameter are thus not needed.
Age-dependent glia cell , mitochondria and immune system alterations are discussed to influence glaucoma.
Age-dependent impairment of islet function and concomitant dysregulation of glycemia are major health threats in aged populations.
Age-dependent intelligibility effects were also found , mainly in sensorimotor cortical areas , and in the left dorsal anterior insula.
Age-dependent restoration of cilia morphology occurs in structurally diverse cilia types and requires IFT.
Age-dependent tissue decline and increased cancer incidence are widely accepted to be rate-limited by the accumulation of somatic mutations over time.
Age , depressive symptoms , gender and the apolipoprotein E ( APOE ) ε4 allele are independently associated with δ.
Age determination from images can be of vital importance , particularly in cases involving suspected child sexual abuse ( CSA ) .
Aged garlic extract ( @number@ mg / ml ) significantly inhibited superoxide production in comparison to the control.
Aged hematopoietic stem cells can differ from their younger counterparts in functional capacity.
Age , diabetes duration , and category of diabetes medication did not significantly modify the HbA1c-hypoglycemia relationship.
Age did not affect any of the proteins and transcripts related to the UPR.
Age did not affect collagen content significantly in auricular ( P = @number@ ) or septal cartilage ( P = @number@ ) .
Age did not affect nerve diameter.
Age did not affect the learning parameters but correlated negatively with working memory and processing speed.
Age did not differentiate significantly the level of neuroticism and of extraversion.
Age did not have an effect on quality of life.
Age did not influenced overall HEI score , neither its components.
Age did not influence sleep in general , but older workers in the quickly forward-rotating three-shift system had less sleep complaints than their younger colleagues.
Age did not moderate the associations between caregiver types and daily experiences.
Age did not seem to moderate healing times.
Age did not significantly influence kinematics.
Age differences appeared in the smoothness ( HR ) at the flat terrain , with increased vertical and antero-posterior values for young adults.
Age differences emerged when examining the availability of working memory resources under threat , with young adults showing decrements , whereas older adults did not.
Age differences for gap detection of complex sounds were generally small and constant when gap-detection thresholds were measured on a log scale.
Age differences found on SMSQ between young and old adults confirm the well-established empirical findings on the memory and aging.
Age differences in anterior regions of the cerebral WM exceeded those in posterior regions.
Age differences in behavioral and neural responses to candy gains / losses were investigated.
Age differences in hippocampal volumes were significant with FreeSurfer , but not with manual tracing.
Age differences in regional volumes collectively accounted for @percent@ of the age-related variance in navigation learning.
Age differences in the ERP old / new effects were also modulated by the level of education.
Age differences in the strategies that individuals spontaneously use to learn new information have been shown to contribute to age differences in episodic memory.
Age differences in this relationship , the moderating effects of health , and lagged effects were also examined.
Age differences were found in feature-selective attentional modulation of visual responses : older adults did not show consistent modulation of magnitude or phase.
Aged individuals ' declining ability to regulate GC levels may therefore impair their ability to cope with stress , as found in humans.
Aged individuals were expected to exhibit elevated fGCM levels under energetically demanding conditions.
Age discrimination is a common problem in organizations.
Age disturbances in the HPA axis functioning are of pathophysiological significance for the development of stress- and age-related pathologies and progression of the aging process.
Aged male rats fed MRJPs showed improved spatial memory up to @percent@ when compared to the control male aged rats fed distilled water.
Aged mammals have higher circulating pro-inflammatory cytokines than young adults , supporting the hypothesis of increased inflammation with aging.
Aged men had higher pathologic assignment score than that of young men , which demonstrated more severe pathologic changes ( p < 0.05 ) .
Aged mice had increased lung inflammation as determined by cytokine analysis and histopathology of lung sections.
Aged mice received nanoparticles weekly and bone mineral density ( BMD ) , bone structure , and bone turnover were quantified.
Aged mice were found to be highly susceptible to pneumococcal challenge in a PsrP , the pneumococcal adhesin that binds K10 , dependent manner.
Aged mice with muscle-specific overexpression of a super-repressor IκBα mutant ( MISR ) were protected from insulin resistance.
Aged muscles also had lower mitophagic potential , based on a @percent@ reduction in Parkin to the voltage-dependent anion channel ( VDAC ) protein ratio.
Aged neuromuscular junctions exhibit elevations in pre-synaptic nerve terminal branching , and in the post-synaptic distribution of receptor sites for neurotransmitter.
Age does not predict hospital admissions or poor control of asthma symptoms if proper treatment is offered.
Age does not seem to be a critical factor determining the functional and rehabilitation outcome in the compensatory treatment of HVFD.
Age dominates as a risk factor for human atherosclerosis , yet the underlying mechanisms remain elusive.
Age ( Dordrecht , Netherlands ) , @number@ ) .
Aged patients are one of the primary target populations for many promising applications.
Aged rat CSMC showed sluggish contractility , concomitant with reduced expression of cav-1 with an associated reduction in activation of PKC-α and RhoA signaling pathway.
Aged rats treated with 17β-estradiol had significantly increased infarct volumes compared with placebo-treated aged rats.
Aged skeletal muscle has an attenuated and delayed ability to proliferate satellite cells in response to resistance exercise.
Aged skin showed significant decreases in the levels of NLRP3 inflammasome proteins.
Aged SNCA-OVX mice exhibit reduced firing of SNc dopamine neurons in vivo measured by juxtacellular recording of neurochemically identified neurons.
Age , education , and sex influences were studied.
Age , education , and sex were included as covariates in all regression analysis.
Age effects in dread-sensitive choices remained nonsignificant even after controlling for a range of age-associated covariates.
Age effects on dual-task costs were examined in healthy adults ( Exp.
Age effects on the fiber structure and material properties were estimated using multivariate models accounting for spatial autocorrelation.
Age effects showed an increased risk of death in all regions.
Age effects were assessed within SnPM as were the effects of voxel subsampling , variance smoothing , and spatial smoothing.
Age effects were evaluated using hierarchical multiple regression analyses.
Age emerged as the major determinant of the CAVI in a stepwise multiple regression analysis ( r ( @number@ ) change = @percent@ ) .
Age-eMS tend to be hypomethylated with older age , located in predicted enhancers and preferentially linked to expression of antigen processing and presentation genes.
Age estimation based on aspartic acid racemization ( AAR ) has been applied successfully to various tissues.
Age estimation based on racemization of aspartic acid residues ( AAR ) in permanent proteins has been established in forensic medicine for years.
Age estimation based solely on the percentage of radicular dentinal translucency has been found to be more accurate when diseased teeth are involved.
Age estimation from DNA methylation markers has seen an exponential growth of interest , not in the least from forensic scientists.
Age estimation involves predicting the age of an individual given his / her facial image.
Age estimation of nonliving subjects plays a very important role in identifying human remains.
Age estimation results on fetuses suffering from lissencephaly demonstrate that they detect significant differences in the age offset compared to a control group.
AgeFactDB ( @url@ is a database aimed at the collection and integration of ageing phenotype data including lifespan information.
Age , fear of falling , pain , physical activity , and physical resilience explained @percent@ of the variance in depressive symptoms.
Age , female gender , baseline weight , BMI and MNA-SF were significant predictors of mortality whereas no specific chronic disease was.
Age , fewer years of education , and functional limitations also were predictive.
Age , free and biodisponible testosteron were the only variables with a positive linear association with erectile dysfunction and decreased sexual desire.
Age , frequency of teeth cleaning , and method used for teeth cleaning were statistically associated with the DMFT score.
Age-friendliness is defined in terms of a range of domains , such as housing , opportunities for participation , and transportation.
Age , FT value and SHIM score showed significant differences between the two groups.
Age functioned as a significant moderator of the mediational pattern.
Age , gender and certain CV co-medications emerged as significant predictors of NOAC prescribing in AF.
Age , gender , and education levels were balanced between the groups.
Age , gender , and education were all significantly associated with SDMT performance , as was poor health , and cultural background.
Age , gender , and education were self-reported.
Age , gender , and education were self-reported.
Age , gender and refractive power were recorded.
Age , gender , and socioeconomic status are shown to bear highly significant associations with individuals ' odds of successful aging.
Age , gender , body mass index , IADL score , GDS score , and use of pchychoactive drugs were measured at baseline.
Age , gender , comorbidity , nutritional status , cognitive status and risk of depression were determined.
Age , gender , duration of residence , language preference and health status change were associated with incident EA.
Age , gender , education , cancer diagnosis , and presence of metastatic disease differentiated among the latent classes.
Age , gender , hearing aid use , baseline depression or loneliness , and relevant confounders and effect modifiers were incorporated.
Age , gender , height , weight , BMI and FEV1 / FVC , FEV1%pred , FEV1 / VCmax were compared between the two groups.
Age , gender , smoking , hypertension , family histories of hypertension and diabetes were recorded.
Age group comparisons showed a significant decrease in younger , but not older subjects.
Age group of 15-44 showed the highest infection rate.
Age groups showed equivalent adaptation of saccadic gain.
Age groups were 1-10 , 11-20 , 21-30 , 31-40 , 41-50 , 51-60 , 61-70 , 71-80 , and 81-90 years.
Age groups were classified as : < 35 , 35-49 , 50-64 , and > or = 65 years.
Age group was not found to moderate the observed effects.
Age group was the predictor variable in this study.
Age had a significantly larger effect on D1- than D2-like receptors.
Age had a small effect on shear wave measurements.
Age had a strong interaction with SBP level ( P < @number@ ) so that younger individuals exhibited greater SBP differences over repeated measures.
Age had no effect on attenuation and RMS profiles.
Age had no effect on the TT level but significantly decreased aFT , cFT , and cbT levels and significantly increased the SHBG level.
Age had significant indirect effects on cognition via brain markers , with significant markers varying across cognitive domains.
Age has a clear impact on one's ability to make accurate goal-directed aiming movements.
Age has also been identified as an independent risk factor for bleeding complications related to anticoagulation therapy.
Age has a significant impact on some aspects of HIV-infection when compared to younger patients.
Age , health status , duration of treatment and sex may thus modify effects of longer-term elevated sex steroid levels on brain function.
Age , hemoglobin , albumin and HDLC were also significant prognostic factors for survival in the present study.
Age-hypermethylated loci were enriched for guanine-and-cytosine-rich regions in CpG islands ( CGIs ) , whereas age-hypomethylated loci were enriched for adenine-and-thymine-rich regions in non-CGIs.
Age impacts multiple neural measures and these changes do not always directly translate into alterations in clinical and cognitive measures.
Age imparts long-term dynamic changes to faces : how these are represented in the human visual system has seldom been investigated.
Age improvements in the ability to connect meaning across words have been found to be necessary and sufficient for developmental increases in the DRM illusion.
Age , in and of itself , is not a predictor of weaning from mechanical ventilation.
Age increased stroke risk for nondrinkers ( P = 0.012 ) and decreased it for heavy drinkers ( P = 0.040 ) .
Age increases vulnerability , commonly accompanied by greater reliance on others and susceptibility to maltreatment.
Age-induced changes in the tissue microenvironment may alter the T-cell responses.
Age influences enrollment greater than health status.
Ageing also plays an important role in GORD pathogenesis by decreasing lower oesophageal sphincter pressure and impairing oesophageal clearance.
Ageing and ageing-mediated defective autophagy involve accumulation of lipofuscin.
Ageing and comorbidities including diabetes , cardiovascular disease , chronic kidney disease and depression were associated with the risk of ED.
Ageing and hearing loss were related to less release from effort when increasing the intelligibility of speech in noise.
Ageing and hyperlipidaemia may be the culprits , but the mechanisms remain unclear.
Ageing and longevity is unquestioningly complex.
Ageing and physiological functions of the human body are inversely proportional to each other.
Ageing appears on the international agenda for more than @number@ years.
Ageing can be defined as the gradual deterioration of physiological functions , increasing the incidence of age-related disorders and the probability of death.
Ageing decreased the tactile perception of hair.
Ageing drivers also tend to make relatively sharper or tighter turns than younger drivers.
Ageing drives changes in neuronal and cognitive function , the decline of which is a major feature of many neurological disorders.
Ageing generally leads to impairments in cognitive function and the ability to execute and learn new movements.
Ageing has been associated with changes in cardiac electrophysiology that result in QT interval prolongation.
Ageing has pronounced effects on the immune system , including on innate immune cells.
Ageing , however , exacerbates the burden of filial care because the ratio of older to younger individuals is higher and disabled parents live longer.
Ageing impairs the muscle anabolic effect of food intake , which may explain muscle loss and an increased risk of sarcopenia.
Ageing increases the risk of the onset of chronic inflammation-associated diseases such as cancer , diabetes , stroke , and neurodegenerative disease.
Ageing in diverse species ranging from yeast to humans is associated with the gradual , lifelong accumulation of molecular and cellular damage.
Ageing-induced changes in arterial biomechanics , among others , are manifested via a marked decrease in the prestretch.
Ageing in humans is typified by the decline of physiological functions in various organs and tissues leading to an increased probability of death.
Ageing in man is associated with changes to the splicing factor pool.
Ageing involves all the spinal component changes.
Ageing involves modifications of the locomotor system which is believed to increase energy consumption.
Ageing is a biological process that results from changes at a cellular level , particularly modification of mRNA.
Ageing is accompanied by a decline in gut microbial diversity , immunity and metabolism , which increases susceptibility to infections.
Ageing is accompanied by reduced immunity , termed immunesenescence , resulting in increased susceptibility to infection.
Ageing is accompanied by the decrease in innate and adaptive immunity , termed immunosenescence.
Ageing is a complex but universal phenomenon that progressively challenges the homeostasis network and finally leads to the dysfunction of organisms and even death.
Ageing is a complex molecular process driven by diverse molecular pathways and biochemical events that are promoted by both environmental and genetic factors.
Ageing is a complex multifactorial process involving a progressive physiological decline that , ultimately , leads to the death of an organism.
Ageing is a complex multifactorial process , reflecting the progression of all degenerative pathways within an organism.
Ageing is a complex process characterised by a systemic and progressive deterioration of biological functions.
Ageing is a complex process characterized by a general decline in physiological functions with increasing morbidity and mortality.
Ageing is a complex process that affects nearly all animal species.
Ageing is a leading risk factor for many debilitating diseases.
Ageing is also associated with a decrease in the effectiveness of the immune system and in alterations to it.
Ageing is also associated with low grade inflammation ( LGI ) , which has been negatively correlated with muscle mass and strength.
Ageing is also associated with shallowing of the anterior chamber and thinning of the cornea.
Ageing is an important factor that affects visual functioning.
Ageing is an inevitable biological process associated with gradual and spontaneous biochemical and physiological changes and increased susceptibility to diseases.
Ageing is a potent , independent risk factor for cardiovascular disease.
Ageing is a prominent risk factor for atherosclerosis and cardiovascular disease.
Ageing is associated with a reduction in strength of between @number@ and @percent@ for the muscles responsible for movement of the foot and ankle.
Ageing is associated with changes in the peripheral T cell immune system , which can be influenced significantly by latent cytomegalovirus ( CMV ) infection.
Ageing is associated with decreases in strength and cardiovascular fitness , and increased cardiovascular risk factors.
Ageing is associated with elevated adiponectin levels.
Ageing is associated with functional , structural and mechanical changes in arteries that closely resemble the vascular alterations in hypertension.
Ageing is associated with physiological modifications that may impair drug pharmacokinetics ( PKs ) .
Ageing is associated with unique issues that modify expression , recognition , and treatment of the disease.
Ageing is a stochastic process associated with a progressive decline in physiological functions which predispose to the pathogenesis of several neurodegenerative diseases.
Ageing is characterized by a progressive decline in the functional reserve of multiple organs and systems , which can influence drug disposition.
Ageing is characterized by declines on a variety of cognitive measures.
Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease.
Ageing is characterized by progressive immunodeficiency , inflammation , and autoimmunity.
Ageing is characterized by the progressive impairment of physiological functions and increased risk of developing debilitating disorders , including chronic inflammation and neurodegenerative diseases.
Ageing is driven by the inexorable and stochastic accumulation of damage in biomolecules vital for proper cellular function.
Ageing is inevitably associated with a decline in physiologic reserves.
Ageing is intrinsically complex , being driven by multiple causal mechanisms.
Ageing is related to slowdown / breakdown of the somatotropic axis ( i.e. the somatopause ) leading to many physiological changes.
Ageing is the greatest challenge that health-care systems will have to deal with this century.
Ageing is the predominant risk factor for many common diseases.
Ageing is the primary risk factor for cognitive deterioration.
Ageing leads to reduced organ function and a decline in physiologic reserve.
Ageing male SHRs could then be used to investigate proposed therapeutic interventions for chronic congestive heart failure in humans.
Ageing may be considered a multifactorial process derived from the interaction between genetic and environmental factors including lifestyle.
Ageing myonucleus still responds to resistant exercise and hormone replacement therapy ( HRT ) by enhancing its transcriptional capacity.
Ageing of the innate and adaptive immune system , collectively termed immune senescence , is a complex process.
Ageing of the neuromuscular system in elderhood ingravescently contributes to slowness , weakness , falling and death , often accompanied by numbness and pain.
Ageing perceptions were generally more negative among Turkish than among Dutch elders.
Ageing perceptions were measured using the 21-item Ageing Perceptions Questionnaire-Short ( APQ-S ) .
Ageing per se is not a key concern of epidemiologists , and detailed biological explanations of causal mechanisms may not be offered by the epidemiologist.
Ageing questions are highlighted.
Ageing remains the biggest risk factor for developing idiopathic Parkinson's disease.
Ageing results from the time-dependent accumulation of random cellular damage.
Ageing , senescence and ultimately death , result from the exhaustion of these mechanisms maintaining cellular functions.
Ageing shows a high interindividual and intraindividual variability.
Ageing tissues are thus increasingly susceptible to chronic diseases associated with ageing.
Ageing was related to a decrease in GM volume , which was in turn related to a decrease in the openness score.
Ageing well was associated with participating in family and community roles , connection with community networks and managing the effects of chronic health problems.
Ageing , which all creatures must encounter , is a challenge to every living organism.
AGE inhibitors might present an emerging therapeutic approach with significant applications in the context of PCOS and infertility.
Age , Injury Severity Score , revised trauma score , body mass index , and pretrauma FIM scores ( 12-point scale ) were studied.
Age , IQ and symptom severity did not predict quality of life in this sample.
Age is a critical factor in the prevalence of tauopathies , including Alzheimer's disease.
Age is a key component of fitness , affecting survival and reproductive capacities.
Age is also an independent risk factor for postmenopausal osteoporosis.
Age is also a prominent risk factor for Alzheimer's disease ( AD ) , where clinical features are similar to age-related decreases in cognitive performance.
Age is a major determinant of MS progression onset and disability.
Age is a major risk factor in age-related macular degeneration ( AMD ) , but the underlying cause is unknown.
Age is an established major risk factor for glaucoma that can be used along with other data to compute chances of developing glaucoma.
Age is a recognized risk factor , contributing to the occurrence of multifactorial diseases.
Age is a robust predictor of recidivism and an item on actuarial tools commonly used to predict sexual violent recidivism among sex offenders.
Age is by far the major risk factor for most chronic diseases.
Age is known to affect sensitivity to retinal motion.
Ageism has many cumulative negative health effects , so reducing ageism in college-age youths can have a significant , long-term impact on public health.
Ageism is intrinsic in the realm of ' averageology'.
Ageism is one of the most socially condoned and institutionalized forms of prejudice in the United States.
Ageism warrants greater recognition , social condemnation , and scientific study as a possible social determinant of chronic disease.
Age is not a barrier to sexually transmitted diseases.
Age is not a limiting factor for ED medical management , and it is never too late to treat.
Age is not related to SIF concentrations.
Age is one of the key risk factors of several human neurodegenerative disorders such as Alzheimer΄s disease and Parkinson΄s disease.
Age is one of the strongest predictors of cardiovascular disease ( CVD ) risk.
Age is the greatest risk factor for the development of epithelial cancers.
Age is the most consistent factor affecting the sleep structure.
Age is the most important risk factor for metabolic alterations and cardiovascular accidents.
Age is the most important risk factor for most diseases.
Age is the primary risk factor for dementia and the long-term social and economic effects of dementia are immense.
Age is the principal nonmodifiable risk factor for stroke.
Ageist messages are everywhere.
Age itself is thought to affect the acute glucose response to stress.
Age itself might not be a critical determinant for the selection of a therapeutic option.
Age itself need not be a contraindication to testosterone treatment of elderly men with LOH.
AgeLine , an EBSCO host database , focuses on literature on topics relating to people over the age of @number@
AgeLine is geared to professionals in aging-related fields , such as health care professionals , social workers , and caregivers , as well as consumers.
A gel mobility shift assay showed that oxidized PTEN migrated more rapidly than reduced PTEN on a non-reducing SDS-PAGE gel.
Age , LVEF , whether taking medication regularly and social support are factors related to cognitive function in CHF patients.
Age , male sex and dependency according to the Instrumental Activities of Daily Living screening instrument were associated with mortality in both phases.
Age , male sex , and HIV status were associated with shorter telomere length.
Age , marital status , education , self-reported hypertension and diabetes were not associated with depressive symptoms after adjusting for confounders.
Age-matched control data are therefore required whenever the performance of an implant is evaluated during a deep knee squat.
Age-matched controls ( n = @number@ ) completed identical testing.
Age-matched controls ( n = @number@ ) underwent structural imaging.
Age-matched control subjects with no history of CMA ( n = 76 ) participated in the follow-up.
Age-matched hypertension exacerbated the effects of aging on systolic pressure , and diastolic function.
Age matching across groups should be undertaken in studies using foveal bulge as prognostic tool.
Age matching and sex matching are strongly recommended in further studies about DED , especially DED following ocular surgery.
Age may affect coronary flow reserve ( CFR ) especially in subjects with atherosclerotic risk factors ( ARFs ) .
Age , method , sample size , sex and tissue variation could elevate effect size bias.
Age , method , sample size , sex and tissue variation were moderators.
Age , myocardial infarct , dementia , diabetes , nonmetastatic tumor , and severe liver disease were risk factors for not undergoing surgery.
Agencies offering CDSMP should encourage caregivers to attend.
Agencies that serve the elderly are rife with policies and practices that resist acknowledging the needs of this population.
Agency is an important factor in postmigration outcomes.
A gender-dependent factor appears to operate and to interact with diagnosis.
A gender-stratified analysis revealed that cheek skin elasticity was significantly improved in the LB group compared with the Control group only in female subjects.
Age negatively moderated the beneficial effects of practice.
Age negatively predicted inhibitory control.
A general cognitive ability score ( g ) was generated by principal components analysis.
A general cognitive function phenotype was tested for , and created in each cohort by principal component analysis.
A general cut-off score ( ≤23 ) was defined and yielded @number@ % sensitivity and @number@ % specificity in detecting Alzheimer disease.
A generalised linear mixed-effects model was used to investigate the association in a longitudinal data form.
A generalized additive model ( GAM ) was used to assess the linearity of these relationships.
A generalized estimating equation was used to examine the association between living arrangements and QoL / HRQoL.
A generalized linear mixed model was used for the data analysis.
A generalized linear model and two-part regression model were applied to estimate costs , with adjustment of covariates.
A generalized linear model ( extended by generalized estimating equations ) was used to assess sex- and age-related differences.
A generalized linear model ( GLM ) was applied in the analysis.
A generalized Procrustes analysis was completed for the landmark sets.
A general linear-model univariate analysis was performed to test the effect of CRF on the decline in HRpeak with age.
A general linear regression model was used to predict the number of steps per day at home.
A general modeling framework is presented which is general enough to model most of observed behaviors.
A general non-linear correlation was found between flexural and indirect tensile strength values.
A general outline is given of possible corrective methods.
A general physical decline of all organ systems and a high frequency of chronic disease accompanying aging.Comorbidity and polypharmacy are therefore common in the elderly.
A general scheme explaining its role in physiopathology is also proposed.
A genetic association was found between p.T96K and FTD-S ( p = @number@ odds ratio = @number@ @percent@ Confidence Interval [ @number@.17-14.77 ] ) .
A genetic component has been implicated in PCa onset and development.
A genetic score combining @number@ independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in @number@ autopsy samples.
A genetic score ( GS ) was calculated on the basis of suggestive single nucleotide polymorphisms ( SNPs ) found by association analyses.
A genetic study in Drosophila gives important insights into the epigenetic control of gene expression implicated in a human mental retardation syndrome.
A genome-wide association study ( GWAS ) of usual sleep duration was conducted using @number@ population-based cohorts totaling @number@ @number@ individuals of European ancestry.
A genome-wide association study identified EIF2AK3 as a risk factor for PSP.
A genome-wide panel of @number@ SNPs was used subsequently to map these biomarkers as quantitative traits.
Agents designed to activate SIRT1 might be developed as treatments for IBDs.
Agents not only symptomatically improving the functional impairments , but also inhibiting the progression of the neurodegenerative processes would be breakthroughs in this area.
Agents targeting inflammation , oxidative injury , atrial myocyte metabolism , extracellular matrix remodeling , and fibrosis have theoretical advantages as novel therapeutic strategies.
Agents that enhance efficacy at lower radiation doses might have considerable value in increasing tumor control without compromising organ function.
Agents work together following flocking rules in order to form a flock.
Age ( @number@ ) could influence the transition from the state of cognitive stability to slight deterioration.
Age @number@ discriminates between better and poorer clinical pregnancy and live birth rates.
Age , number of close relatives and frequency of contact were not associated with loneliness.
Age @number@ ( range 56-66 ) cardiometabolic outcomes included hypertension , diabetes , dyslipidemia , inflammation , and ischemic heart disease.
Age of diagnosis and duration of diabetes largely determine the likelihood for comorbidity.
Age of first depressive episode was classified into early-onset depression ( < @number@ years ) and late-onset depression ( ≥ @number@ years ) .
Age of onset in multiple sclerosis ( MS ) exerts an influence on the course of disease.
Age-of-onset was determined based on self-report , with EOD defined as onset prior to age @number@
Age of participants ranged from @number@ years to @number@ years , with a mean of @number@ years.
Age of patients and brain oxidative stress may contribute to pathogenesis of Alzheimer's disease ( AD ) .
Age of patients with BP was @number@ ± @time@ .
Age of the caregivers varied from @number@ to @number@ years.
Age of the donors appears as one parameter that could greatly affect MSC properties.
Age or body mass did not influence fGCM significantly in the rainy season.
Age or stress-induced disruption of normal neuronal-microglial communication could lead to an aberrant central immune response when additional stressors are applied.
Age paired healthy volunteers ( n = @number@ ) were also recruited ( control group ) .
AGE , Pent in FF and TAGE in serum showed significant negative correlations with ongoing pregnancy.
Age plays a crucial role in the interplay between tumor and host , with additional impact due to irradiation.
Age ( p < @number@ ) and fusion ( p < @number@ ) were also significant variables in each analysis.
Age , race , and sex , but not poverty status , were associated with the likelihood of a physical examination.
Age , RA disease duration , and triglycerides were predictors of cfPWV in multivariate analyses.
AGE-RAGE interaction stimulates generation of reactive oxygen species and inflammation mechanisms which enhance AGE formation.
AGE-RAGE receptor binding causes the synthesis and secretion of VEGF.
Age reduced or increased social capital inequalities in hypertension depending on the age category.
Age-regulated mRNA expression trends from cross-sectional studies could describe how aging progresses.
Age-related activation decreases were observed within more posterior regions including posterior cingulate , insula and posterior cerebellar cortices , presumably mediating visual-spatial saliency detection.
Age-related activation of these receptors inhibits the work of insulin genes in β-cells.
Age-related ADL reference values were calculated using questionnaire data.
Age-related alterations in brain structure and function have been challenging to link to cognition due to potential overlapping influences of multiple neurobiological cascades.
Age-related alterations in immunity have been linked to increased incidence of infections and decreased responses to vaccines in the aging population.
Age-related alterations in the functional architecture of the DMN and HC may influence memory functions and possibly constitute a sensitive biomarker of forthcoming memory deficits.
Age-related alterations in the levels of laminin , fibronectin and perlecan in vascular basement membranes were also noted in wild-type mice.
Age-related alterations of CMI were observed as well , but they correlated little with those of walking.
Age-related alterations of dermal proteoglycans have not been fully elucidated.
Age-related alterations to positive modulation emerged later in the lifespan than negative modulation.
Age-related alterations to the immune system have also been studied and documented.
Age-related anatomical changes to the surface of the pubic symphysis are well-documented in the literature.
Age-related body composition changes were also observed independent of body mass index.
Age-related bone loss and resultant osteoporosis put the elderly population at an increased risk for fractures and morbidity.
Age-related bone loss is a common worldwide phenomenon in the aging population , placing them at an increased risk of fractures.
Age-related bone loss is in large part the consequence of senescence mechanisms that impact bone cell number and function.
Age-related brain activation increases were only apparent during performance of the visuomotor task.
Age-related cardiac remodeling is known to be accompanied by changes in extracellular matrix ( ECM ) gene and protein levels.
Age related cardiovascular changes predispose the individual to arterial hypertension , heart failure and arrythmia.
Age-related cataract has become one of the most serious problems facing the aging population in the world.
Age-related cataract is a cause of blindness on a global scale involving genetic and environmental influences.
Age-related cataractogenesis is associated with disulfide-linked high molecular weight ( HMW ) crystallin aggregates.
Age-related change in bone density and geometry was observed.
Age-related change in episodic memory function is commonly reported in older adults.
Age-related change in the concentration of αA- ( 66-80 ) peptide was estimated by mass spectrometry.
Age-related changes and sexual differences of some of the morphometric characteristics of the lower part of facial skeleton were studied.
Age-related changes differed between boys and girls suggesting a different developmental timing for the sexes.
Age-related changes have been documented in anatomical studies on peripheral as well as central vestibular systems.
Age-related change should be accounted for in any assessment of RNFLT.
Age-related changes in auditory spatial perception of linguistic and non-linguistic stimuli in participants between @number@ and @number@ years of age were studied.
Age-related changes in autobiographical memory ( AM ) recall are characterized by a decline in episodic details , while semantic aspects are spared.
Age-related changes in cardiac homeostasis can be observed at the cellular , extracellular , and tissue levels.
Age-related changes in CD4⁺ T-cell composition can be prevented by an early initiation of cART.
Age-related changes in cognition are partially mediated by the presence of neuropathology and neurodegeneration.
Age-related changes in CSA and CT were almost identical to that of BMD.
Age-related changes influence the pathophysiology and role of allergy in elderly asthmatic patients.
Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals.
Age-related changes in immune function leave older adults at risk for a host of inflammatory diseases.
Age-related changes in lens astigmatism appear to be related to changes in the anterior lens astigmatism.
Age-related changes in lipid and cholesterol maintenance , particularly in the brain , may be central to healthy aging and longevity.
Age-related changes in memory CD4 T cells ( CD4 ) are poorly known.
Age-related changes in neuroplasticity may be central to the cognitive decline associated with healthy ageing.
Age-related changes in noncartilage tissue should be incorporated in the understanding of OA development.
Age-related changes in physical abilities , such as strength and flexibility , contribute to functional losses.
Age-related changes in running kinematics have been reported in the literature using classical inferential statistics.
Age-related changes in skin contribute to impaired wound healing after surgical procedures.
Age-related changes in sleep parameters may have a negative impact on memory consolidation in older adults.
Age-related changes in spindles may be responsible for impaired motor sequence learning consolidation , but the morphological basis for this deficit is unknown.
Age-related changes in splice-forms of LMNA , which encodes the nuclear lamina proteins lamin A / C , have not been investigated in skeletal muscle.
Age-related changes in testosterone are believed to be a key component of the processes that contribute to cognitive aging in men.
Age-related changes in the cardiovascular and autonomic nervous systems make age-associated increases in ABPV likely.
Age-related changes in the determinants of cPP should be considered when investigating the clinical value of cPP.
Age-related changes in the facial skin were especially well-apparent in women with the lowered activity level and impaired mood.
Age-related changes in the microstructural organization of the corpus callosum ( CC ) may explain declines in bimanual motor performance associated with normal aging.
Age-related changes in these parameters ( absolute values and z-scores ) were explored by obtaining simple linear regression models for each group.
Age-related changes of cystatin C in the RPE from the posterior pole may compromise its extracellular functions , potentially contributing to AMD pathogenesis.
Age-related changes of jaws and soft tissue profile are important both for orthodontists and general dentists.
Age-related changes of the eye can result in ophthalmological diseases.
Age-related changes were found both in children's ability to select the correct item and their ability to remember the problem.
Age-related changes were markedly different in each of the @number@ subgroups ( compared with healthy controls ) .
Age-related cognitive decline ( ARCD ) and dementia are of increasing concern to an ageing population.
Age-related cognitive decline is a major public health concern facing a large segment of the US population.
Age-related cognitive decline is caused by an impacted neuronal circuitry , yet the molecular mechanisms responsible are unknown.
Age-related cognitive declines are common and inevitable , but life trajectories of brain and cognitive functions are variable and plastic.
Age-related comorbidities increase the risk of cognitive impairment in HIV infection.
Age-related conditions are the leading causes of death and health-care costs.
Age-related decline in cognitive function has been linked to alterations of white matter and functional brain connectivity.
Age-related decline in executive functions can be decisive in performing everyday tasks autonomously.
Age-related decline in fertility starts after @number@ years.
Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures , leading to a decline in functional efficiency.
Age-related decline in processing speed has long been considered a key driver of cognitive aging.
Age-related decline in sensitivity was more rapid in the periphery.
Age-related decline only partially explained the variability seen in the association.
Age-related declines in central processing may delay the facilitation of corticospinal ( CS ) tracts that underlie emergence of voluntary responses to external stimuli.
Age-related declines in relational encoding are well documented.
Age-related declines in source memory have been observed for various stimuli and associated details.
Age-related decreased production of new neurons in the neurogenic dentate gyrus has been associated with memory impairments.
Age-related decrease in functional connectivity was also noted in the auditory , right frontoparietal , sensorimotor , and visual medial networks.
Age-related decrease in maximum IVC diameter and increase in the respirophasic IVC collapsibility may indicate the decrease in right atrial pressure in some elderly patients.
Age related decrease in reproductive functions leads to decline in the number of oocytes retrieved and the synthesis of endometrial receptivity molecules.
Age-related decrease of testosterone levels in blood and brain is believed to be associated with neurodegenerative diseases such as Alzheimer's disease.
Age-related decreases in material-independent activity linked to postretrieval monitoring were observed in right lateral PFC.
Age-related decreases in post-training modulatory effects suggest reduced experience-dependent plasticity in the aging brain.
Age-related decreases in skeletal muscle quantity , termed sarcopenia , have traditionally been blamed for these physical decrements.
Age-related decreases in vagal nerve activity could contribute to orthostatic hypotension in older individuals.
Age-related decrements in performance were strongest for the speed of face cognition but were also salient for face perception and face memory.
Age-related decrements within the sensorimotor system may lead to alterations and impairments in postural control , but a link to a vestibular mechanism is unclear.
Age-related defects of the immune system are responsible for T cell unresponsiveness to cancer vaccination at older age.
Age-related deficits in selective attention have often been demonstrated in the visual modality and , to a lesser extent , in the auditory modality.
Age-related degeneration of intracortical inhibition could underlie declines in cognitive function during senescence.
Age-related degeneration of the white matter further leads to a growing number of T2 hyperintense white-matter lesions.
Age-related dementias such as Alzheimer disease ( AD ) have been linked to vascular disorders like hypertension , diabetes and atherosclerosis.
Age-related deterioration can be accelerated by physical disruption , which leads to disc \ "degeneration \ " or prolapse.
Age-related deterioration in cognitive ability may compromise the ability of older adults to make major financial decisions.
Age-related differences in cognitive agility vary greatly between individuals and cognitive functions.
Age-related differences in face memory were still salient after taking into account changes in general cognitive functioning.
Age-related differences in gray matter mainly involved the frontal lobes.
Age-related differences in hip abduction moments may reflect greater muscular effort by older adults to reduce the likelihood of becoming unstable.
Age-related differences in LV relaxation and diastolic suction were not attenuated significantly when PCWP was increased in older subjects or reduced in the younger subjects.
Age-related differences in patterns of association were also examined.
Age-related differences in performance were also found with small displacements ; however , these were largely accounted for by age-related declines in visual acuity.
Age-related differences in the 3D LV twist may be the result of the age-related changes in the endocardial myofibers.
Age-related differences in the anterior P2 and N2 to novel stimuli likely represent age-associated changes in independent cognitive operations.
Age-related differences in the level of each protein were investigated.
Age-related differences were demonstrated for CoP composite scores in AP direction ( tandem eyes open ; semi-tandem eyes closed ; p < @number@ ) .
Age-related differences were evident in the electroencephalographic ( EEG ) signals.
Age-related differences were investigated in @number@ young and @number@ middle-aged male school teachers.
Age-related differences were limited to No Match pair accuracies at @number@ dB SNR.
Age-related differences were noticeable in the radius too , without any obvious group difference.
Age-related difficulties in episodic prospective memory ( PM ) are common.
Age-related diseases such as CVD have been previously associated with increased endothelial cell senescence.
Age-related disorders are associated with increased cellular stress and assault including DNA damage , reduced energy availability , protein aggregation and accumulation of damaged organelles.
Age-related disorders in Human include disturbances of biological rhythms , especially sleep-wake rhythms alterations , and perturbations of body temperature and hormone secretion.
Age-related DNA damage has been regarded as one of the possible explanations of aging , and these age-related changes have been associated with lifestyle variables.
Age-related dopamine ( DA ) losses have been extensively demonstrated for the D2 receptor subtype.
Age-related dysfunction of the central auditory system , known as central presbycusis , is characterized by defects in speech perception and sound localization.
Age-related EBV ( + ) B-cell LPD encompasses a wider disease spectrum than previously recognized and includes both reactive and neoplastic conditions.
Age-related effects on brain activity during encoding and retrieval of episodic memories are well documented.
Age-related effects on novelty processing have been reported and are linked with changes in frontal lobe functioning.
Age-related ERP enhancements in such studies have often been interpreted in terms of elevated sensitivity to auditory stimulation.
Age-Related Eye Disease Study vitamins may reduce progression to severe ARMD.
Age-related hearing impairment ( ARHI ) , or presbycusis , is a complex disease with multifactorial etiology.
Age-related hearing loss ( ARHL ) , also known as presbycusis , is one of the most prevalent chronic degenerative conditions.
Age-related hearing loss ( ARHL ) , the hearing loss associated with aging , is a vital problem in present society.
Age-related hearing loss is typified by high-frequency threshold elevation and associated reductions in speech perception because speech sounds , especially consonants , become inaudible.
Age-related hearing loss , or presbyacusis , is a major public health problem that causes communication difficulties and is associated with diminished quality of life.
Age-related hearing loss - presbycusis - is the number one neurodegenerative disorder and top communication deficit of our aged population.
Age-related hypogonadism appears to be different to other ' classical ' causes of hypogonadism.
Age-related hypometabolism was found in anterior regions , including the anterior cingulate gyrus.
Age-related increase in frailty is accompanied by a fundamental shift in cellular iron homeostasis.
Age-related increase of acoustic density of different lens zones was revealed that indirectly shows method efficiency.
Age-related increases in subexcitability may be attributable to changes in the muscle fibre and not the nerve.
Age-related loss of muscle bulk and strength ( sarcopenia ) is often cited as a potential mechanism underlying age-related changes in swallowing.
Age-related loss of muscle mass and function greatly affects quality of life in the elderly population.
Age-related loss of muscle mass and function represents personal and socioeconomic challenges.
Age-related loss of skeletal muscle mass and strength are risk factors for sarcopenia , osteoporosis , falls , fractures , frailty , and mortality.
Age-related lower SW density in men was especially marked in prefrontal / frontal brain areas , where they originate more frequently.
Age-related macular degeneration ( AMD ) affects the region of the retina that is responsible for high-resolution vision.
Age-related macular degeneration ( AMD ) , cataract , glaucoma and diabetic retinopathy are common causes of visual loss.
Age-related macular degeneration ( AMD ) is a common and devastating disease that can result in severe visual dysfunction.
Age-related macular degeneration ( AMD ) is a common vision-threatening condition affecting the elderly.
Age-related macular degeneration ( AMD ) is a leading cause of blindness in the western world.
Age-related macular degeneration ( AMD ) is a leading cause of blindness worldwide.
Age-related macular degeneration ( AMD ) is a major cause of central vision loss in persons over 55years of age in developed countries.
Age-related macular degeneration ( AMD ) is a major cause of visual impairment that affects the central retina.
Age-related macular degeneration ( AMD ) is a progressive blinding disease and represents the leading cause of visual impairment in the aging population.
Age-related macular degeneration ( AMD ) is a sight threatening eye disease that affects millions of humans over the age of @number@ years.
Age-related macular degeneration ( AMD ) is characterized by a central vision loss.
Age-related macular degeneration ( AMD ) is one of the leading causes of vision loss in the elderly.
Age related macular degeneration ( AMD ) is the leading cause of blindness in individuals older than @number@ years of age.
Age-related macular degeneration ( AMD ) is the leading cause of vision loss in developed countries.
Age-related macular degeneration ( AMD ) is the leading cause of vision loss in those over the age of @number@ years in the developed countries.
Age-related macular degeneration ( AMD ) is the most common reason of visual impairment in the elderly in the Western countries.
Age-related macular degeneration ( AMD ) leads to progressive loss of central vision in the elderly.
Age-related macular degeneration ( ARMD ) is the leading cause of irreversible blindness in developed countries.
Age-related macular degeneration is the leading cause of blindness and visual impairment in patients older than @number@ years in developed countries.
Age-related macular disease ( AMD ) accounts for more than @percent@ of blind registration in Western society.
Age-related mechanisms that lead to sarcopenia are not entirely understood.
Age-related memory deficits were greater for the less educated individuals.
Age-related metastatic mineralization of soft tissues has been considered a passive and spontaneous process.
Age-related microstructural differences have been detected using diffusion tensor imaging ( DTI ) .
Age-related modifications accompanying cerebral maturation during infancy and childhood will be detailed.
Age-related modifications also occur in naïve / memory B cells subsets.
Age-related morphological atrophic changes and cellular alterations are addressed by neural aging mechanisms.
Age-related muscle atrophy is due to loss of muscle fibers as well as atrophy of the remaining fibers.
Age-related muscle loss impacts on whole-body metabolism and leads to frailty and sarcopenia , which are risk factors for fractures and mortality.
Age-related muscle loss , termed sarcopenia , has been linked to functional deficits and an increased risk of falling.
Age-related neural patterns during search replicated prior reports of age-related decreases in posterior recruitment and increases in prefrontal recruitment.
Age-related nomograms for the 5th , 25th , 50th , 75th , and 95th percentiles of AMH were produced.
Age-related OA pathogenesis is not well understood.
Age-related pathologies are commonly seen in elderly patients.
Age-related physiological changes in distribution , metabolism , and elimination often alter the effects of pharmacotherapies in older adults.
Age-related renal changes and the effects of Hg in the kidney have been characterized separately.
Age-related sensorimotor changes and increased muscle coactivation likely alter the trial-and-error-based process of adapting to new movement demands ( motor adaptation ) .
Age-related shape differences were detected in the orbits , zygomatic arches , and maxillary alveolar process.
Age related skin changes can be measured using clinical and biophysical methods.
Age related sleep disturbances and sleep disorders due to the neurodegeneration including REM sleep behavior disorder also increase in dementia.
Age-related social and financial changes and society's perception of older people may also present challenges to condition management.
Age-related spherical aberration increased only in the internal component ( @number@.019 / y , P = @number@ ) .
Age-related spike localization was uniformly observed , regardless of the epileptic syndrome.
Age-related structural , functional and biochemical changes of the brain can be visualized by neuroimaging methods.
Age-related thymic involution is accompanied by a decrease in thymopoiesis and , thus , a deficiency in T cell-mediated immunity in the elderly.
Age-related traits at locations with ontogenetic and biomechanical relevance were broken into components and scored.
Age-related trajectories of inhibition and effects of gender were examined in @number@ children ( @number@ boys ) aged @number@ to @number@ years.
Age-related trajectories of risk factors were assessed by fitting mixed-effects models with adjustment for year of birth to reveal secular trends.
Age-related variations in DNA methylation have been reported ; however , the functional relevance of these differentially methylated sites ( age-dMS ) are unclear.
Age-related variations in the radii of curvature of the crystalline lens modify slightly its shape factor , reducing the compensation of lateral coma.
Age-related white matter changes ( ARWMC ) appear to correspond to a continuum from normal functioning to clinically overt neurological syndromes.
Age-relevant differences in motivation and successful emotion regulatory efforts based on theoretical and empirical literatures are discussed.
Age remained a significant risk factor for serous neoplasia after age adjustment.
Age remains the most powerful prognostic factor among glioblastoma ( GBM ) patients.
AGEs are known to participate in many age-related human diseases , including cardiovascular , neurological , and liver diseases.
AGEs are present in all renal compartments in diabetic patients , including the vessels , glomeruli , tubules and interstitium.
AGEs are proinflammatory and can modify the extracellular matrix.
AGEs are therefore accepted biomarkers for aging , diabetes , and several degenerative diseases.
AGEs are thought to contribute to defective skin repair in diabetic patients as well as a result of the normal aging process.
Age , SBP , BMI , and smoking in children influence ACR.
AGEs decreased cell viability in AECs , even at low concentration , while fibroblast viability was less affected.
Age seems to be an important factor influencing atazanavir pharmacokinetics.
Age-sensitive components of this model may be of value as biomarkers in human studies that evaluate anti-aging interventions.
Age sex adjusted prevalence of visual disabilities and their @percent@ Confidence Intervals ( CI ) were estimated.
Age , sex , and education were covariates.
Age , sex and education were entered as covariates.
Age , sex , basic demographics , anthropometric data and X-rays of both hands were collected.
Age- , sex- , education-adjusted differences reached significance for CN versus newly discovered and prevalent dementia and for MCI versus prevalent dementia.
Age , sex , education , and body mass index were included as covariates.
Age-sex interaction was significant in torque amplitudes and in electromechanical delay ( P < @number@ ) .
Age × sex interaction was significant mainly in the hemispheric analysis , with men undergoing sharper age-related changes.
Age , sex , pPP , but not FBG and HDL-C levels , have independent association with cPP.
Age , sex , pPP , FBG , and HDL-C levels have independent association with cfPWV.
Age , sex , socioeconomic and cultural conditions , chronic morbidities , polypharmacy , and previous morbidities were also tested as potential confounders.
AGEs formation occurs as a result of sequential glycation and oxidation reaction between reducing sugars and protein.
AGEs have been associated with insulin resistance , oxidative stress , and chronic inflammation in patients with diabetes.
AGEs have been considered to play a significant role in lens aging and cataract formation.
Age , shift work exposure time , and shift type seemed not to affect shift work tolerance in this population.
Age should not be considered an exclusion criterion from surgery per se.
Age should not be considered as a contraindication for complex procedures in neurosurgery.
Age showed an indirect correlation with the distance to the meatus , the sinus volume , and the mediolateral dimensions.
Age showed no significant associations with nanoindentation parameters.
Age significantly interacted with number of MUS in explaining variance in HRQoL but not with the number of MES.
Age significantly modified the relationship between aPWV and TL ( P < @number@ ) .
Age significantly predicted MPOD score ( R ( @number@ ) = @number@ p < @number@ ) .
Age simulation suits are used to demonstrate typical physical impairments of older age ( e.g. , strength and sensory losses ) in younger individuals.
Ages @number@.92 + 1.95 @date@ .12 + 0.62 years ( P - N.S. ) and @percent@ @date@ @percent@ male ( p < 0.0001 ) .
Age-specific analyses show that correlations between working conditions , health , and turnover intention differ substantially across the age groups.
Age-specific characteristics seem to be less relevant.
Age-specific cutoff point for WC might be considered to identify subjects at risk for MetS.
Age-specific death risks were calculated for each calendar year for individuals having at least one child and for individuals without children.
Age-specific harmonized testosterone concentrations in nonobese men were similar across cohorts and greater than in all men.
Age-specific incidence rates were modelled as a function of age , period-birth cohort using NORDPRED.
Age-specific negative dynamics of maximum phonation time was not documented.
Age-specific normative values for circulating AMH concentration were established.
Age-specific prostate cancer mortality suggested significantly increasing trend for ages 65-74 and ≥ @number@ years.
Age-specific stroke incidence is generally higher in men , except in the elderly.
Age , spherical equivalent and corneal diameter were significantly correlated with mean keratometry reading in the multivariate model.
AGEs production takes place throughout the normal aging process but its accumulation is found to be more rapid in diabetic patients.
Ages ranged from 22-77 y.
Ages ranged from @number@ to @number@ years.
Ages ranged from @number@ to @number@ years.
Ages ranged from @number@ to @number@ years of age.
Ages ranged from @number@ to @number@ years with a median ( IQR ) of @number@ ( 62-81 ) years.
AGEs significantly increased monocytic THP-1 cell adhesion to HUVECs , which was also prevented by @number@ ng / ml n-butanol extracts of noni.
Age-standardized acute myocardial infarction incidence and angina prevalence decreased globally between @number@ and @number@ ischemic heart failure prevalence increased slightly.
Age-standardized death rates ( ASDRs ) for all cancers combined decreased within that timeframe in @number@ of @number@ countries or territories.
Age-standardized disability prevalence differs markedly by state , from @percent@ in North Dakota and Minnesota to @percent@ in West Virginia.
Age-standardized mortality rates ( ASMRs ) were calculated by means of direct standardization.
Age-standardized PQI rates were computed following AHRQ specifications.
Age-stratified ( < 60 versus ≥60 years ) regressions revealed the Trauma association was only significant for older adults.
Age-stratified analyses were performed.
AGEs trigger proinflammatory , profibrotic and procoagulant cellular responses that are capable of damaging tissues , often targeting particular organs.
Age-structured population dynamics , vaccine efficacy ( VE ) per strain , and weekly ramp-up of vaccination coverage are modeled.
Age synthesis is defined to rerender a face image aesthetically with natural aging and rejuvenating effects on the individual face.
Age trajectories of all-diseases mortality are studied in Austria , the Czech Republic , Hungary , Poland , and Slovakia.
Age trajectories of mortality are analyzed separately : before the age category where mortality reaches its minimal value and after the age category.
Age trajectories of total mortality represent an irreplaceable source of information about the relationship between mortality and age.
Age was also a significant risk factor ( P = @number@ ) for acute delirium for CF patients.
AGE was also found to preserve pre-synaptic protein synaptosomal associated protein of @number@ kDa ( SNAP25 ) from ROS-mediated insult.
Age was also negatively associated with the self-reported sleep quality item and sleep duration component of the PSQI.
Age was a significant predictor of delayed sleep and activity schedules ( p ≤ @number@ ) .
Age was a significant predictor of Trails A scores with older age associated with worse performance.
Age was associated with all parameters except spinal canal diameter.
Age was associated with an increase and Hispanic ethnicity with a decrease in the prevalence of high HDL-C.
Age was associated with cCSA in women ( r = @number@ P = @number@ ) , but not in men.
Age was associated with mean NFL thickness.
Age was associated with the risk of stroke ( alone ; RR , @number@ @percent@ CI , @number@ @date@ ) .
Age was categorized according to three groups ( 20-39 , 40-59 , and ≥ @number@ years ) .
Age was correlated to greater volumes of Aβ plaques and vessels.
Age was correlated with BMI ( R = @number@ p = @number@ ) .
Age was estimated using Moorrees et al.
Age was found to negatively affect the ability to decode basic negatively valenced emotions as well as pleasant surprise.
Age was identified as a likely modifier of the association between antidepressant use and some form of cognitive impairment or AD / dementia.
Age was independently correlated with body functionality score ( model r2 = 0.037 ) .
Age was inversely related to physical component summary , which was inversely related to the 3-BSRS-subitem sum score.
Age was irrelevant in fact recognition , but older adults were less successful than younger in tune recognition.
Age was negatively related to general mental ability , with older executives scoring lower than younger executives.
Age was negatively related to retinal vessel densities , the inner retinal layers , and venular BFV ( P < @number@ ) .
Age was not a predictor of the 30-day risk of composite stroke or death.
Age was not a significant seroconversion factor.
Age was not associated with baseline cognitive test performance.
Age was not associated with COPD-related hospitalization , all-cause ED visits , or COPD-related ED visits.
Age was not associated with non-participation in either study ( CFAS I , P = @number@ CFAS II , P = @number@ ) .
Age was not correlated with the thicknesses of the LF.
Age was not related to cytokine levels , and age relationships did not differ between diagnostic groups.
Age was not related to masticatory performance ( β = -0.007 , P = 0.753 ) .
Age was only found to have an effect on the performance of visuo-spatial memory tests , and the effect of sex was negligible.
Age was positively associated with receiving any care while the male gender showed a negative association.
Age was positively correlated with envelope-IPD thresholds at both carrier frequencies and TFS-IPD thresholds at @number@ Hz , when absolute thresholds were accounted for.
Age was positively related to WB , L2-L4 and @date@ radius BMD and BMAD.
Age was positively related to work ability and negatively related to health.
Age was significantly associated with all balance measures.
Age was significantly associated with both altered DNA methylation and expression of @number@ genes ( e.g. FHL2 , NOX4 and PLG ) .
Age was significantly associated with the MRI-inflammation-score after adjusting for CRP and SJC ( β = 1.018 , p = 0.027 ) .
Age was significantly correlated with the mean fat percentages ( r2 = @number@ P = @number@ ) .
Age was still significant ( p ≤ @number@ ) .
Age was stratified by decade of death , and linear regressions were calculated by ABO percentage.
Age was the dominant risk factor for the progression of arterial stiffness.
Age was the main factor determining the difference in clinic BP and ABP by multiple linear regression analyses.
Age was the only independent variable for both , erectile dysfunction and sexual desire , in the multiple linear regression.
Age was the strongest predictor of tremor.
Age , weight and job had a significant effect on the time intervals between donations.
Age , weight , sex , diabetes and kidney function were associated with sclerostin.
AGE-α-synuclein converted biphasic Tm to higher monophasic Tm.
AGE-α-synuclein could stabilize the uncoiled scDNA , as shown by the decrease in the number of ethidium bromide binding molecules per base pair of DNA.
A GGGGCC repeat expansion in the C9orf72 gene was recently identified as a major cause of familial and sporadic amyotrophic lateral sclerosis and frontotemporal dementia.
Aggravation of allergic rhinitis coincides with exacerbation of asthma , whereas treatment of nasal inflammation improves control of the asthma.
Aggregated alpha-synuclein inclusions are found where cell death occurs in several diseases , including Parkinson's disease , dementia with Lewy bodies , and multiple-system atrophy.
Aggregates in the granular cells had a globus appearance and mimic Pick's-like inclusions.
Aggregates of the microtubule-binding protein , tau , are one of the most important pathogenic molecules in neurodegenerative disorders.
Aggregation occurred in the temperature range 35-45 °C , in which the mutant protein began to lose the native conformation of its N-terminal domain.
Aggregation of risk factors may be especially important in this association.
Aggregation-prone polyglutamine ( polyQ ) expansion proteins cause several neurodegenerative disorders , including Huntington disease.
Aggregation tests were performed by multiple electrode aggregometry.
Aggresome formation is also observed in other neurodegenerative diseases , suggesting that an activation of similar mechanisms must occur in neurodegeneration as a basic phenomenon.
Aggression was most frequently reported , by @percent@ ( n = @number@ ) of care home managers , as a difficult behaviour to manage.
Aggressive antiresorptive therapy may be warranted in high-risk patients.
Aggressive , goal-directed management in the surgical intensive care unit is beneficial for the geriatric patient.
Aggressiveness did not change.
AG had better diastolic function than SG.
Agility and dynamic balance performance were mostly relevant with falling risk.
Agility was highest in the active and low sedentary group ( P < @number@ ) .
Aging affected muscle power more than muscle strength , which could be due to fast fiber reduction.
Aging affects all of the anatomic structures involved in the swallowing process.
Aging affects almost all physiological processes , but changes in body composition and body phenotype are most observable.
Aging affects endogenous stem cells in terms of functionality and numbers.
Aging affects male fertility by a scope of factors , which are not fully understood to date.
Aging affects the ability of older adults to continue to live safely and economically in their own residences for as long as possible.
Aging affects the complex interaction between HIV infection and the immune system.
Aging affects various structural and metabolic properties of the brain.
Aging also affects neuroglial cells.
Aging also affects wound repair , pigmentation , innervation , immunity , vasculature , and subcutaneous fat homeostasis.
Aging also alters the expression of collagen-binding integrins in conventional NK cells and the frequency and phenotype of liver tissue-resident NK cells.
Aging also brings about an increase in the frequency of profiles of paranodes , indicating that some of the nerve fibers are being remyelinated.
Aging also causes endothelial dysfunction and predisposes to negative remodeling.
Aging also decreases connexin43 ( Cx43 ) expression in bone ; and osteocytic Cx43 deletion partially mimics the skeletal phenotype of old mice.
Aging also results in a location shift for a number of structures indicating the need for visualization of the anatomy of individual brains.
Aging also shows sex differences in model organisms.
Aging and AD may be accompanied by independent impairments of visual processing for reading and navigation.
Aging and AD were associated with poorer heading and speed perception at lower temporal periodicity , with smaller effects of spatial texture.
Aging and age-related diseases are associated with cellular senescence that results in variable apoptosis susceptibility to oxidative stress.
Aging and age-related diseases are associated with losses in melatonin secretion and rhythm amplitudes.
Aging and Alzheimer is a prospective , longitudinal cohort study involving @number@ adults aged ≥65 years from selected areas in Cuba's Havana and Matanzas Provinces.
Aging and Alzheimer's disease ( AD ) are associated with declines in the visual perception of self-movement that undermine navigation and independent living.
Aging and autobiographical memory : Dissociating episodic from semantic retrieval.
Aging- and autophagy-related molecules were determined by immunohistochemistry and hematoxylin and eosin staining.
Aging and blade tenderization combined can increase tenderness and value of Longissimus steaks from cull Holstein cows.
Aging and cancer demonstrate profound genome-wide DNA methylation changes , suggesting that nutrition may affect the aging process and cancer development through epigenetic mechanisms.
Aging and changes in the physiologic reserves generate a decreased perception of symptoms associated with hypoglycemia , increasing the risk of unawareness or severe episodes.
Aging and delayed P300 latency correlated with lower FA.
Aging and digitalisation are important trends which have their impact on information accessibility.
Aging and DM were correlated with the prevalence of hearing loss ( p < 0.05 ) .
Aging and inactivity cause atrophy and weakness of the muscle , leading to a loss of the heart-assisting role.
Aging and increased amyloid burden are major risk factors for cognitive diseases such as Alzheimer's disease ( AD ) .
Aging and inflammation are major contributing factors to the development and progression of arthritic and musculoskeletal diseases.
Aging and its aligned loss of muscle mass are associated with higher levels of DNA damage and deteriorated antioxidant defence.
Aging and its underlying pathophysiological background has always attracted the attention of the scientific society.
Aging and lipotoxicity are two major risk factors for gout that are linked by the activation of the NLRP3 inflammasome.
Aging and many age-related diseases have in common the expression of misfolded and damaged proteins.
Aging and many disease conditions , most notably diabetes , are associated with the accumulation of non-enzymatic cross-links in the bone matrix.
Aging and mechanical loading are believed to influence development of osteoarthritis ( OA ) , yet the connection remains unclear.
Aging and muscle unloading are associated with a decline in muscle mass , structure , force and changes in the mechanical properties of skeletal muscle.
Aging and obesity can play a synergic effect on accelerating the renal function deterioration.
Aging and / or BT improves sensory panel tenderness cull cow Longissimus lumborum steaks.
Aging and polycystic ovary syndrome , a diabetes-associated disease , often cause infertility.
Aging and poor lifestyle choices are associated with metabolic impediments to NO production.
Aging and population growth do not fully explain this increase in the diabetes burden.
Aging and reduced physical activity ( PA ) may both decrease microvascular function.
Aging and several neurodegenerative diseases bring about changes in the anatomy and physiology of the choroid plexus.
Aging and severity at admission affect levels of key factors of the immune system in the blood of these patients.
Aging and simultaneous nutritional deficiency exert a cumulative influence on the immune response.
Aging and smoking are consistent determinants for both image alterations.
Aging and trauma cause loss of function of articular cartilage , resulting in osteoarthritis ( OA ) .
Aging , antiretroviral drugs , traditional bone loss risk factors , and lifestyle all contribute to bone deterioration in the setting of HIV.
Aging , antiretroviral therapy , chronic inflammation , and several other factors contribute to the increased risk of cardiovascular disease in patients infected with HIV.
Aging appeared to provoke a defective erythrocyte antioxidant defense associated with increased oxidative damage in the elderly population.
Aging appears to be intrinsically related to carcinogenesis.
Aging appears to reduce the normal ability of estrogen to increase ER-α expression in postischemic cerebral microvessels.
Aging appears to reduce the relative impact of the diseases commonly associated with CTS as the possible risk factors.
Aging appears to spare the ability to access multiple cues when making JOLs.
Aging-associated alterations in composition , diversity and functional features of intestinal microbiota are well-described in the modern literature.
Aging-associated cardiovascular diseases ( CVDs ) have some risk factors that are closely related to oxidative stress.
Aging-associated decline in androgen levels is associated with risks of age-related disorders such as sarcopenia and disability in older adults.
Aging-associated diseases are often caused by progressive loss or dysfunction of cells that ultimately affect the overall function of tissues and organs.
Aging-associated dysfunction of microglia comprises phenotypes resembling cellular senescence , which could contribute to cognitive impairments observed in various neurodegenerative diseases.
Aging-associated immune dysfunctions may reflect a diminution in the cellular nimbleness of immune responsiveness.
Aging-associated senescence and apoptosis result in reduced number and functionality of lin- BMCs , impairing their prorepair capacity.
Aging-associated stress simultaneously drives proinflammatory remodeling , involving angiotensin II and other factors , in both the heart and large arteries.
Aging-associated thinning and lengthening of the lower eyelid are reduced by midfacial-submalar preparation ( Aston @number@ ) .
Aging attenuates the viability and function of these stem cells , leading to inconsistent rates of bony union.
Aging augments ROS , which might exacerbate MI / R injury.
Aging , both of individuals and populations , presents challenges and opportunities.
Aging brain reacts strongly to ischemia-reperfusion injury with an early inflammatory response.
Aging can be complex and is associated with various molecular modifications in cells that accumulate over a person's lifetime including epigenetic patterns.
Aging can be defined as the result of accumulated cellular damage and deregulation of the epigenome.
Aging can be understood as a multidimensional process involving physical , neuropsychological , and social changes , which can be highly variable between individuals.
Aging carries with it a series of physiological changes ; one of them is an imbalance in the hemostatic system.
Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability.
Aging causes the basal activation of perilymphatic mast cells , which , in turn , restricts recruitment / activation of immune cells in perilymphatic tissues.
Aging cells cease to divide and drive the progression of illness through various pathways.
Aging changes and the presence of comorbidities add complexity to the care of cancer survivors.
Aging changes as well as health conditions can impact an individual's visual function , making it more difficult to accurately perform work activities.
Aging coincides with a decline in LLMS.
Aging contributes to physiological decline and vulnerability to disease.
Aging decreased myonuclear domain and increased protein expression of p27 ( Kip1 ) .
Aging decreased WBSF.
Aging decreases the efficiency of postural control regardless of the assessment conditions.
Aging decreases the human femur's fatigue resistance , impact energy absorption , and the ability to withstand load.
Aging delayed the latency of this alpha synchronization for both face and letter stimuli , and reduced its amplitude for ignored letters.
Aging dependent stiffness or degeneration of backbone correlates with CAXII expression level.
Aging , diabetes , cardiovascular disease and spinal cord injury can influence these factors.
Aging did not change the side asymmetry ( laterality ) of the gyri.
Aging diminishes the activational effects of sex hormones in sex-specific manners , which is hypothesized to contribute to the relationship between aging and AD.
Aging disrupts skin barrier function and induces xerosis accompanied by pruritus.
Aging , DM , CVD and dialysis vintage were associated with significant VC in both groups.
Aging does not appear to affect cognitive functioning to a greater extent than in HC.
Aging effect appears to be stronger on influencing perceptual than semantic encoding processes.
Aging effect on REM sleep percentage was significant in both groups.
Aging effects are demonstrated , providing an electrokinetic fingerprint of changes in adsorbed protein configuration with time.
Aging employees with a low education and chronic somatic disease had the highest levels of musculoskeletal disorder related work disability.
Aging encompasses the biological changes most often seen as declines of function and increasing burden of disease.
Aging enhances the entry of Ca ( 2 + ) into brain neuronal cells across the plasma membranes.
Aging enteric neurons have been shown to exhibit a senescence-associated phenotype.
Aging ex-POWs who develop psychiatric symptomatology should be considered a high-risk group entering a high-risk period in the life cycle.
Aging femoral neck declines in bending strength and increases in buckling susceptibility.
Aging , frailty , dementia and depression are independent clinical entities ; they may present separately but may also potentiate each other.
Aging had a significant effect on the shear bond strength of the @number@ self-adhesive resin cements to zirconia.
Aging had no significant effect on the relation.
Aging has a broad impact on the function of the human hematopoietic system.
Aging has a detrimental effect on exercise performance.
Aging has a profound influence on arterial wall structure and function.
Aging has a remarkable effect on cardiovascular homeostasis and it is known as the major non-modifiable risk factor in the development of hypertension.
Aging has been associated with a decline in relational memory , which is critically supported by the hippocampus.
Aging has been associated with adverse fibrosis.
Aging has been a subject of interest since primordial times.
Aging has been considered the main risk factor for AD.
Aging has been demonstrated to aggravate obesity and to induce abnormalities of the HPA axis.
Aging has been demonstrated to aggravate obesity and to induce leptin resistance and hyperleptinemia.
Aging has significant effects on the healing ability of the geriatric population.
Aging has traditionally been related to impairments in name retrieval.
Aging , heart failure , LVH , and drugs used may play more important roles.
Aging , HIV , and MA all converge on prefrontal and temporolimbic neural systems and confer independent risk for neurocognitive and functional decline.
Aging , HIV infection , and antiretroviral therapy have been associated with increasing rates of chronic comorbidities in patients with HIV.
Aging , however , appears to be the major contributor for morbidity and mortality of the impaired cardiovascular system.
Aging HS still have to cope with high levels of psychache while realizing a life-long process of development through resilience.
Aging , hypercholesterolaemia , hypertension , obesity , arteriosclerosis , and smoking are risk factors to develop AMD and AD.
Aging , hypertension , and female preponderance are the common risk factors for both RAMs and CAs.
Aging impacts airway responses and immune function , and influences efficacy of emerging phenotype-specific therapies when applied to the elderly patient.
Aging impacts both innate and adaptive arms of the immune system to impair control of viral infections.
Aging impairs blood vessel function and leads to cardiovascular disease.
Aging impairs the ability of alveolar macrophages to limit lung damage during influenza infection.
Aging impairs the control of many skilled movements including speech.
Aging increases the risk of developing obesity , sarcopenia , osteoporosis , and , also , cardiovascular diseases.
Aging in custody and the rising population of elderly prisoners are creating compelling challenges for criminal justice , prison and public healthcare systems.
Aging individual needs to take advantage of these developments to lead a self-regulated life.
Aging individuals can experience frailty and loss of independence and autonomy.
Aging induced a latency delay of the N1 component for faces and letters , as well as of the face N170 component.
Aging-induced elevation in C1q secretion activates the Wnt signaling pathway in muscles , leading to the development of muscle fibrosis.
Aging induces changes in body composition , such as an increase in visceral fat and reduced muscle mass.
Aging influenced both e-liquid NNR and aerosol NNR.
Aging influenced E ' and E″ ( P < @number@ ) .
Aging , injuries , and diseases can be considered as the result of malfunctioning or damaged cells.
Aging in Latin-America has been characterised by its rapid pace which , in turn , has been accompanied by growing urbanisation and globalisation.
Aging in mammals associates with the development of peripheral insulin resistance.
Aging in men is associated with a decrease in testosterone ( T ) levels.
Aging in place is a preferred and cost-effective living option for older adults.
Aging in place is desirable from the perspective of older adults and policy makers alike.
Aging in place refers to the option where people can stay in their homes as they age.
Aging in rodents and men is associated with reduced serum levels of testosterone and Leydig cell testosterone productions.
Aging in saliva produced a positive effect on micro-mechanical properties.
Aging in Sweden has been uniquely shaped by its history-most notably the long tradition of locally controlled services for older adults.
Aging intervention might be an advantageous target for prevention and treatment of diverse age-related diseases.
Aging intestinal smooth muscle cells exhibit a number of changes in the signalling pathways that regulate contraction.
Aging in trained painters is often accompanied by a decline in creativity , which in turn is due to the cognitive decline related to aging.
Aging involves a deterioration of cell functions and changes that may predispose the cell to undergo an oncogenic transformation.
Aging involves a progressive decline of metabolic function and an increased incidence of late-onset degenerative disorders and cancer.
Aging involves selective changes in attentional control.
Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems.
Aging is a biological process characterized by time-dependent functional declines that are influenced by changes in redox status and by oxidative stress-induced inflammatory reactions.
Aging is a biological process that affects most cells , organisms and species.
Aging is a biological process that affects the entire body , following the period of development and it is considered the final stage of biomorphosis.
Aging is accompanied by a general decline in the physiological functions of the body with the deteriorating organ systems.
Aging is accompanied by a progressive decline in the integrity of the immune system , a process known as immunosenescence.
Aging is accompanied by declines in both working memory and long-term episodic memory processes.
Aging is accompanied by declining function and remodeling of body systems.
Aging is accompanied by inexorable loss of muscle tissue.
Aging is accompanied by loss of subcutaneous adipose tissue.
Aging is accompanied by reduced regenerative capacity of all tissues and organs and dysfunction of adult stem cells.
Aging is accompanied by substantial changes in brain function , including functional reorganization of large-scale brain networks.
Aging is accompanied with several degenerative disorders including cardiovascular , neuronal and metabolic diseases.
Aging is a common characteristic of multicellular eukaryotes.
Aging is a common risk factor of many disorders.
Aging is a complex and not well understood process.
Aging is a complex and progressive process that involves physiological and metabolic deterioration in every organ and system.
Aging is a complex biological process characterized by a progressive decline of organ functions leading to an increased risk of age-associated diseases and death.
Aging is a complex biological process that leads to several physiological changes.
Aging is a complex , heterogeneous , and multifactorial phenomenon , which is the consequence of multiple interactions between genes and environment.
Aging is a complex phenomenon involving multiple physiological functions.
Aging is a complex physiological process that poses considerable conundrums to rapidly aging societies.
Aging is a complex process not only influenced by inherited but also by several environmental factors.
Aging is a complex process resulting from , among other , dynamic non-linear interactions between genetics and environment.
Aging is a complex process that affects multiple organs.
Aging is a continuous process that induces many alterations in the cytoarchitecture of different organs and systems both in humans and animals.
Aging is a contributing factor in cancer occurrence.
Aging is a critical factor to influence the functional performance during daily life.
Aging is a critical risk factor for impaired glucose tolerance and diabetes.
Aging is a dominant risk factor for end-stage renal disease.
Aging is a global decline of physiological functions , leading to an increased susceptibility to diseases and ultimately death.
Aging is a gradual biological process characterized by a decrease in cell and organism functions.
Aging is a heterogeneous process , thus , to assess the individual state of health when making decisions is essential.
Aging is a key risk factor associated with the onset of cardiovascular disease.
Aging is also associated with bone demineralization.
Aging is a major risk factor for most chronic diseases.
Aging is a major worldwide medical challenge.
Aging is a multifactorial process influenced by genetic factors , nutrition , and lifestyle.
Aging is a natural process accompanied by a progressive accumulation of damage in all constituent macromolecules ( nucleic acids , lipids and proteins ) .
Aging is a natural process by which every single living organism approaches its twilight of existence in a natural way.
Aging is a natural process characterized by a progressive functional impairment and reduced capacity to respond adaptively to environmental stimuli.
Aging is a natural process characterized by progressive functional impairment and reduced capacity to respond appropriately to environmental stimuli and injury.
Aging is a natural process involving complex interplay between environment , metabolism , and genes.
Aging is a natural process that involves a general decline in many physiological functions , resulting in loss of function and eventually death.
Aging is a natural process that is associated with cognitive decline as well as functional and social impairments.
Aging is an established variable related to spondylotic myelopathy.
Aging is an independent risk factor for myocardial fibrosis.
Aging is an inevitable and multifactorial biological process.
Aging is an inevitable biological process , associated with gradual and spontaneous biochemical and physiological changes , and increased susceptibility to diseases.
Aging is an inevitable part of life and brings along two inconvenient events : physiologic decline and disease state.
Aging is a normal process of every living species.
Aging is a normal process of living being.
Aging is an unavoidable process characterized by gradual failure of homeostasis that constitutes a critical risk factor for several age-related disorders.
Aging is an uncontrollable risk factor , which plays a crucial role in coronary artery atherosclerosis.
Aging is an unequivocal risk factor for human α-synucleinopathies.
Aging is a Parkinson's disease ( PD ) risk factor.
Aging is a physiologic state in which a progressive decline of organ functions is accompanied with the development of age-related diseases.
Aging is a process of progressive decline in physiological functions resulting in increased vulnerability to diseases and death.
Aging is a process that is inevitable , and makes our body vulnerable to age-related diseases.
Aging is a process that occurs from changes in various levels of the cell , from genes to functions.
Aging is a progressive degeneration of the tissues that has a negative impact on the structure and function of vital organs.
Aging is a risk factor for both.
Aging is a risk factor for chronic kidney disease ( CKD ) and many features of CKD are reproduced in the aging kidney.
Aging is a risk factor for heart failure , which is a leading cause of death world-wide.
Aging is a risk factor for peripheral neuropathy / SPN.
Aging is associated to disrupted contractility and rhythmicity , among other cardiovascular alterations.
Aging is associated to dysfunctional changes in the immune system , a process termed immunosenescence.
Aging is associated to respiratory muscle strength reduction ( both inspiratory and expiratory ) .
Aging is associated with a decline in attention and executive function.
Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy.
Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery.
Aging is associated with a decline in immune function.
Aging is associated with a decline in mitochondrial function and the accumulation of abnormal mitochondria.
Aging is associated with a decline in proteostasis and we observed increased protein levels of CHIP as well as BAG2 in senescent cells.
Aging is associated with a decline in sex hormone production.
Aging is associated with a decline in the normal functioning of the immune system.
Aging is associated with a decline of various body functions , including ability to regenerate.
Aging is associated with a decreased renal function and increasing comorbidities , but few data are available regarding plasma lactate levels in this unique population.
Aging is associated with a decrease in hormonal secretion , lean mass and bone mass , and an increase in fat accumulation.
Aging is associated with a gradual decline in this functional aspect of endothelial regulation of cardiovascular homeostasis.
Aging is associated with a gradual increase in damaged and misfolded protein , which places additional stress on the machinery of the proteostasis network.
Aging is associated with a large heterogeneity in the extent of age-related changes in sensory , motor , and cognitive functions.
Aging is associated with alterations in insulin secretion and action.
Aging is associated with alterations in the intestinal microbiota and with immunosenescence.
Aging is associated with alterations in thoracolumbar curvatures and respiratory function.
Aging is associated with an altered TSH secretion.
Aging is associated with an attenuated physiological ability to dissipate heat.
Aging is associated with an increased risk of problems related to the locomotive organs.
Aging is associated with an increased susceptibility to infections and diseases.
Aging is associated with an increase in a chronic , low-grade inflammation.
Aging is associated with an increase in circulating inflammatory factors.
Aging is associated with an increasing prevalence of chronic diseases , including type @number@ diabetes mellitus and its chronic and acute complications.
Aging is associated with a number of pathologies involving various organs including the skeleton.
Aging is associated with a progressive decline in immune function ( immunosenescence ) resulting in an increased susceptibility to viral and bacterial infections.
Aging is associated with a progressive decline in skeletal muscle mass and strength.
Aging is associated with a progressive decrease in hemoglobin concentration , which predicts adverse outcome , such as mortality , morbidity , frailty and disability.
Aging is associated with a progressive deterioration in the structure and function of the pulmonary circulation.
Aging is associated with a progressive loss of bone-muscle mass and strength.
Aging is associated with a reduced capability of the immune system to adequately respond to pathogens and to prevent tumor formation.
Aging is associated with a reduction in skeletal muscle mass-sarcopenia-the etiology of which is multifactorial.
Aging is associated with a reduction in the DNA repair capacity under oxidative stress.
Aging is associated with a reduction of the overall heart rate variability ( HRV ) and a decrease of complexity of autonomic cardiac regulation.
Aging is associated with a tissue degeneration phenotype marked by a loss of tissue regenerative capacity.
Aging is associated with attenuated thermoregulatory function that varies regionally over the body.
Aging is associated with changes in alertness regulation and cognition.
Aging is associated with changes in biological functions , such as reduced cardiovascular responses to stressful tasks.
Aging is associated with changes in left atrial ( LA ) structure and function.
Aging is associated with characteristic changes to sleep quantity and quality , which make it more difficult to adjust sleep-wake rhythms to changing environmental conditions.
Aging is associated with chronic diseases and an increasing number of concomitant diseases.
Aging is associated with cognitive and sensory decline.
Aging is associated with decline in cardiovascular , autonomic function , and brain-derived neurotropic factor ( BDNF ) .
Aging is associated with declines in executive function.
Aging is associated with decreased skeletal muscle function.
Aging is associated with deficits in the ability to ignore distractions , which has not yet been remediated by any neurotherapeutic approach.
Aging is associated with degenerative changes in articular surfaces leading to quantitative and qualitative impairment of joint motion.
Aging is associated with deterioration in the structure and function of the pulmonary circulation.
Aging is associated with gradual decline of skeletal muscle strength and mass often leading to diminished muscle quality.
Aging is associated with immunosenescence and accompanied by a chronic inflammatory state which contributes to metabolic syndrome , diabetes and their cardiovascular consequences.
Aging is associated with impaired motor performance across a range of tasks.
Aging is associated with impaired upper limb proprioceptive acuity , as reflected by decreased position matching accuracy with increasing task complexity and movement extent.
Aging is associated with impairments in homeostasis.
Aging is associated with important changes in both the distribution and the composition of adipose tissue.
Aging is associated with increased arterial stiffness ( pulse wave velocity , PWV ) and muscle strength / mass loss.
Aging is associated with increased circulating pro-inflammatory and lower anti-inflammatory cytokines.
Aging is associated with increased incidence and prevalence of both cancer and anemia.
Aging is associated with increased production of pro-oxidants and accumulation of oxidative end products.
Aging is associated with increased risk for type @number@ diabetes , resulting from reduced insulin sensitivity and secretion.
Aging is associated with increased susceptibility to a variety of chronic diseases , including type @number@ diabetes mellitus , cancer , and neurological diseases.
Aging is associated with increased vulnerability to inflammatory challenge.
Aging is associated with increases in ( HPA ) axis activity that can predispose to metabolic and cognitive impairments.
Aging is associated with increasing predisposition to multiple chronic diseases.
Aging is associated with loss of endurance ; however , aging is also associated with decreased fatigue during maximal isometric contractions.
Aging is associated with loss of skeletal muscle mass , strength and endurance.
Aging is associated with low-grade inflammation.
Aging is associated with many complex diseases.
Aging is associated with many complex diseases such as cancer and neurodegenerative diseases.
Aging is associated with microstructural changes in brain tissue that can be visualized using diffusion tensor imaging ( DTI ) .
Aging is associated with modifications of the immune system and this could contribute to a reduced prevalence of allergic disease in the elderly.
Aging is associated with modifications of the immune system , defined as immunosenescence.
Aging is associated with not only AD but also obesity and type @number@ diabetes ( T2DM ) .
Aging is associated with oxidative damage to DNA , RNA , and lipids.
Aging is associated with oxidative stress-generated damage to DNA and this could be related to metabolic disturbances.
Aging is associated with physical decline , often accompanied by pathology and disability that can cause unhappiness and dissatisfaction.
Aging is associated with polymorbidity and polypharmacy.
Aging is associated with progressive decline in renal function along with concurrent morphological changes that ultimately lead to glomerulosclerosis.
Aging is associated with progressive declines in REE , which partly is explained by loss of fat free mass ( FFM ) .
Aging is associated with reduced mTORC1 signaling following resistance exercise , but the role of amino acid transporters is unknown.
Aging is associated with reduced tissue regenerative capacity.
Aging is associated with reductions in gray matter volume and cortical thickness.
Aging is associated with sarcopenia , which is a loss of skeletal muscle mass and function.
Aging is associated with significant changes in structure and function of the kidney , even in the absence of age-related comorbidities.
Aging is associated with systemic inflammation and cellular apoptosis accelerating physiological dysfunctions.
Aging is associated with the decrease in the ability of cells to cope with cellular stress , especially protein aggregation.
Aging is associated with the functional decline of cells , tissues , and organs.
Aging is associated with widespread changes in genome-wide patterns of DNA methylation.
Aging is associated with widespread qualitative and quantitative changes of the motor cortex.
Aging is a stage of life of all living organisms.
Aging is a time-related process of functional deterioration at cellular , tissue , organelle , and organismal level that ultimately brings life to end.
Aging is attended by a progressive decline in protein homeostasis ( proteostasis ) , aggravating the risk for protein aggregation diseases.
Aging is a well-known risk factor associated with oral diseases.
Aging is a well-known risk factor for a large number of chronic diseases , including those of the lung.
Aging is a well-recognized risk factor for several different forms of cardiovascular disease.
Aging is becoming a critical heath care issue and a burgeoning economic burden on society.
Aging is causing a marked increase in the pandemic of diabetes in elderly people.
Aging is characterized by a cumulative loss of genome integrity , which involves chromatin reorganization , transcriptional dysregulation and the accumulation of DNA damage.
Aging is characterized by an increasing morbidity and functional decline that eventually results in the death of an organism.
Aging is characterized by a profound remodeling of the epigenetic architecture in terms of DNA methylation patterns.
Aging is characterized by a progressive alteration of homeostatic mechanisms modulated by environmental and genetic factors.
Aging is characterized by a progressive decline in organism functions due to the impairment of all organs.
Aging is characterized by heterogeneity , both in health and illness.
Aging is characterized by increased risks for metabolic disorders , with age-associated degenerative diseases exhibiting varying degrees of mitochondrial dysfunction.
Aging is characterized by multiple changes of the musculoskeletal system physiology and function.
Aging is characterized by progressive impairment of functional capacities of all system organs , reduction in homeostatic mechanisms , and altered response to receptor stimulation.
Aging is characterized by substantial changes in sleep architecture altering memory consolidation.
Aging is characterized by the general decline in tissue and body function and the increased susceptibility to age-related pathologies , such as cancer.
Aging is characterized by weight and lean body mass losses.
Aging is complex , dynamic and personal.
Aging is considered the major risk factor for cancer , one of the most important mortality causes in the western world.
Aging is correlated with the rate and type of contact sensitization because of \ "immunosenescence. \ "
Aging is defined as the accumulation of progressive organ dysfunction.
Aging is determined as the product of an interaction among genetic , environmental and lifestyle factors.
Aging is exemplified by progressive , deleterious changes that increase the probability of death.
Aging is explored by multiple lines of research , in a pursuit of understanding this natural process.
Aging is frequently characterized by the accumulation of altered proteins and dysfunctional mitochondria.
Aging is generally accompanied by a progressive loss of skeletal muscle mass and impairments in metabolic function.
Aging is identified by a progressive decline of physiological integrity leading to age-related degenerative diseases , but its causes is unclear.
Aging is indeed associated with immune dysfunction that coexists with a chronic subclinical inflammatory status.
Aging is inevitable but age-related diseases may be modifiable.
Aging is influenced by endocrine pathways including the growth hormone / insulin-like growth factor-1 ( GH / IGF ) axis.
Aging is intrinsically associated with a progressive decline in muscle strength and mass , and aerobic capacity.
Aging is known to be a dominant risk factor in the progression of hypertension.
Aging is known to have deleterious effects on cerebral white matter , yet little is known about these white matter alterations in advanced age.
Aging is linked to deficiencies in immune responses and increased systemic inflammation.
Aging is marked by changes that affect organs and resident stem cell function.
Aging is more likely to lead to atherosclerosis in the coronary arteries , particularly in the left main coronary artery and its main branches.
Aging is normal process , only somehow questioned by the \ "anti-aging wave \ ".
Aging is not and cannot be programmed.
Aging is not associated with an increased incidence of wound dehiscence.
Aging is not associated with a reduced response to EAAs provided the EAA content is sufficient.
Aging is not a uniform process.
Aging is not \ "genetically programmed \ " , it is outside evolutionary constraint.
Aging is not synonymous with disability.
Aging is often accompanied by cognitive impairments and influenced by oxidative status and chemical imbalances.
Aging is often accompanied by functional limitations that affect self esteem , lowering the level of satisfaction with life.
Aging is one of the major risk factors for Alzheimer's disease ( AD ) .
Aging is one of the major risk factors for the development of heart and vascular diseases.
Aging is one of the major risk factors of osteoarthritis.
Aging is one of the most challenging and unresolved problems in biology owing to its highly complex nature.
Aging is one of the most complicated biological processes in all species.
Aging is one of the most extensively studied biological process and yet still some of its aspects remain elusive.
Aging is one of the most important risk factors for most chronic diseases.
Aging is one of the prime risk factors for the development of cancer.
Aging is progressively deteriorating physiological function that leads to increasing risks of illness and death.
Aging is related to a chronic increase in inflammatory cytokines.
Aging is related to a progressive remodeling of the neuromuscular system , which includes muscle mass , strength , and power reductions.
Aging is significantly associated with the development of comorbid chronic conditions.
Aging is the best-known risk factor for many disorders , including neurodegenerative diseases such as Alzheimer's disease ( AD ) .
Aging is the biggest risk factor for human disease and results in a wide range of aging pathologies.
Aging is the main risk factor associated with AD.
Aging is the main risk factor contributing to vascular dysfunction and the progression of vascular diseases.
Aging is the main risk factor for cardiovascular diseases , but the associated molecular mechanisms are poorly understood.
Aging is the main risk factor for many chronic degenerative diseases and cancer.
Aging is the major factor of GFR and Ccr reduction in the healthy population.
Aging is the major risk factor for both the development of chronic diseases and loss of functional capacity.
Aging is the major risk factor for cardiovascular diseases ( CVD ) .
Aging is the major risk factor for many human diseases.
Aging is the most important risk factor.
Aging is the most important risk factor for the development of LOAD.
Aging is the most significant risk factor for Alzheimer disease ( AD ) .
Aging is the outcome of a balance between damage and repair.
Aging is the predominant risk factor for neurodegenerative diseases.
Aging is the primary risk factor for developing neurodegenerative diseases.
Aging is the primary risk factor for numerous chronic , debilitating diseases.
Aging is the primary risk factor of neurodegenerative disorders such as Alzheimer's disease ( AD ) .
Aging is the principal demographic risk factor for Alzheimer disease ( AD ) , the most common neurodegenerative disorder.
Aging is the single greatest risk factor for the development of disease.
Aging is the strongest risk factor for cancer development , suggesting that molecular crosstalks between aging and tumorigenesis exist in many cellular pathways.
Aging is the strongest risk factor for cognitive decline.
Aging is thought to negatively affect multiple cellular processes including the ability to maintain chromosome stability.
Aging is thought to occur through the accumulation of biochemical damage affecting DNA , proteins , and lipids.
Aging is tightly associated with redox events.
Aging is unmistakable and undeniable in mammals.
Aging is usually accompanied by a significant reduction in muscle mass and force.
Aging is widely considered to be associated with limited balance capacity.
Aging itself is a complex biological process with a poorly understood mechanism of its regulation.
Aging itself is attributed by a popular theory to free radicals.
Aging itself may cause renal damage , but the spectrum of kidney disorders that affect elderly patients is diverse.
Aging itself was not a risk factor for postoperative complications or the survival outcome.
Aging kidneys undergo structural and functional changes that decrease autoregulatory capacity and increase susceptibility to acute injury.
Aging KO mice show characteristics consistent with premature bone marrow exhaustion.
Aging leads to accumulation of irreversible advanced glycation end-products ( AGEs ) , contributing to vascular stiffening and endothelial dysfunction.
Aging leads to global changes in brain structure and cognitive performance , with reorganization of functional brain networks.
Aging leads to inherent changes in mesenchymal stem cell ( MSC ) differentiation , resulting in impaired osteoblastogenesis.
Aging leads to reduced immunity , especially adaptive responses.
Aging led to a statistically significant decrease in the MTBS for all groups , except the untreated one ( NE ) .
Aging , lifestyle factors , and comorbidities increase the risk of developing chronic conditions such as diabetes mellitus and chronic kidney disease.
Aging mainly affected SOM neurotransmission in piriform and entorhinal cortex in wild-type mice , although olfactory performances decreased.
Aging , male gender , low levels of physical activity , and smoking were found to be associated with poor masticatory function.
Aging males with significant erythrocytosis , untreated sleep apnea , prostate cancer and high risk of cardiovascular events must be excluded from testosterone replacement therapy.
Aging Male Symptom Score , International Index of Erectile Function , and International Prostate Symptom Score questionnaires were widely used for questionnaires.
Aging may begin when the rate of damage exceeds the rate of continual repair and turnover.
Aging may be viewed as a multifactorial process that results from the interaction of genetic and environmental factors , which include lifestyle.
Aging may cause various disorders such as disabilities , high risk conditions and some chronic disease.
Aging may enhance both oxidative stress and bone-marrow mesenchymal stem-cell ( MSC ) differentiation into adipocytes.
Aging may impair protein folding , and the accumulation of oxidized and misfolded proteins may stimulate the UPR at rest in aged muscle.
Aging may predispose older patients to greater risk.
Aging mechanisms that are more relevant to the bone microenvironment include alterations in the expression and signaling of local growth factors and altered intercellular communications.
Aging meta-perceptions are differentiated into the cognitive and affective components of ageism.
Aging modulates dispersion of ventricular repolarization , which may contribute to the cardiac mortality in the very old Asian population.
Aging negatively affects angiogenesis which is found to be linked to declined vascular endothelial growth factor ( VEGF ) production.
Aging not only renders patients more susceptible to these disorders , but also attenuates their self-repair capabilities.
Aging , not physical activity , appears to modulate cardiovascular responses to acute inflammation , except in the most active older adults.
Aging nurse faculty members are vital human resources who serve as educators , researchers , and leaders within baccalaureate nursing ( BSN ) programs.
Aging , obesity , and excessive alcohol consumption were independent correlates of knee pain in the studied population sample.
Aging occurs as a series of small steps , first causing cellular damage and then affecting tissues and organs.
Aging of an individual entails a progressive decline of functional reserves and loss of homeostasis that eventually lead to mortality.
Aging of biological systems is controlled by various processes which have a potential impact on gene expression.
Aging of cardiac stem / progenitor cells ( CSCs ) impairs heart regeneration and leads to unsatisfactory outcomes of cell-based therapies.
Aging of ECFCs by serial passaging led to increased senescence and reduced proliferation of GDM-exposed ECFCs.
Aging of ECM is a complex process , comprising progressive modification of its macromolecular components and of cell-matrix interactions.
Aging of ECs may impair their ability to maintain HSC function contributing to the development of aging-associated hematopoietic deficiencies.
Aging of Holocaust survivors ( HS ) is especially difficult when focus is brought to the issue of integrating their life history.
Aging of long-lived post-mitotic cells is characterized as a progressive and irreversible reduction of functional activity.
Aging often results in a decline in cognitive function , related to alterations in the prefrontal cortex ( PFC ) activation.
Aging of the brain is characterized by several neurochemical modifications involving structural proteins , neurotransmitters , neuropeptides and related receptors.
Aging of the face is inevitable and undeniable.
Aging of the immune system may result in decreasing efficacy of vaccination , especially for adults aged above 65-70 y.
Aging of the lower eyelid involves a complex series of anatomic and physiologic changes that occur over time.
Aging of the periocular area involves changes of the skin , muscle , fat , and bones.
Aging of the population and improvements in diabetes therapy have led to an increased number of older pancreas transplant candidates.
Aging of the population contributed to these increases.
Aging of the population is a growing problem in all developed societies.
Aging of the population is expected to further increase the prevalence of type @number@ diabetes , particularly in the age group over @number@
Aging of the population is one of the dominant trends in the XXI century.
Aging or cerebral diseases may induce architectural modifications in human brain microvascular networks , such as capillary rarefaction.
Aging organelles and protein aggregates are degraded by the autophagosome-lysosome pathway , which is particularly crucial in neurons.
Aging , overuse , and microtraumas can be responsible for enthesis-degenerative phenomena.
Aging p38 MAPK mutant flies display accelerated motor function decline , concomitant with an enhanced accumulation of detergent-insoluble protein aggregates in thoracic muscles.
Aging , pathology or trauma may affect its histo-morphological configuration and mechanical response.
Aging patients will have decreased energy needs relative to a reduction in lean body mass.
Aging per se is not a comorbidity.
Aging per se may be associated with physiologic abnormalities in the systemic arteries and with endothelial dysfunction.
Aging persons with chronic epilepsy exhibit multiple abnormalities in metabolic , inflammatory , and vascular health that are associated with poorer cognitive function.
Aging phenotypes and interventions are often sex-specific , indicating that both male and female sexual differentiation promote mitochondrial failure and aging.
Aging physiology greatly impacts care delivery in the geriatric patient population.
Aging plays an essential role in cardiac pathophysiology.
Aging population , dense urbanization , and poor access to health care make the Asia-Pacific region vulnerable to CAP.
Aging population has been advancing in Ito city located in the northern part of Izu peninsula.
Aging population is a major concern that is reflected in the increase of chronic diseases.
Aging population is considered to be major problem in modern healthcare.
Aging population is increasingly in need of effective care and therapies for brain diseases , including stroke , Parkinson's disease and Alzheimer's disease.
Aging population , non-ischemic cardiovascular diseases , acute and chronic severe comorbidities , all increased the susceptibility to develop life-threatening critical settings.
Aging populations , however , maintain CVD as a major threat to public health and health system's financial stability.
Aging processes , illnesses , malnutrition , difficulties in communication and comprehension , psychological alterations and social needs may coexist and overlap.
Aging processes of the trabecular meshwork and the uveoscleral outflow pathway lead to a rise in the intraocular pressure.
Aging process is supposed to be a leading predictor for developing OA.
Aging process or senescence affects the expression of a wide range of phenotypic traits throughout the life span of organisms.
Aging products were analyzed by GC-MS.
Aging prolonged relaxation , reduced spontaneous heart rate ( HR ) and increased the occurrence of arrhythmias , ectopic beats and asystoles.
Aging reduces coronary flow reserve in patients with angiographically normal coronary arteries due to a gradual increase of resting coronary flow velocity.
Aging-related appetite dysregulation may partly account for the difference in results from studies in young and older adults.
Aging-related cell-surface NADH oxidase ( arNOX ) -specific activities increase with age between age @number@ and ages 50-65.
Aging-related diseases show a marked sex bias.
Aging-related loss of BubR1 and subsequent impairment of reactivity to ROS may explain reduced proliferative capacity of aged smooth muscle cells.
Aging-related proteins P53 and P16 were quantified in Western blot , which also examined activation of Janus kinase @number@ ( JAK2 ) signal pathway.
Aging-related tau astrogliopathy ( ARTAG ) is a recently introduced terminology.
Aging-related weakness is due in part to degeneration within the central nervous system.
Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate.
Aging represents an important health issue not only for the individual , but also for society in general.
Aging represents per se a risk factor for AD.
Aging represents the major cause of loss of smell , although a number of clinical and environmental factors are thought to affect chemosensory function.
Aging represents the major risk factor for cancer.
Aging researchers have long been interested in understanding individuals ' subjective perceptions of their own memory functioning.
Aging research should address the implications of kinless-ness for public health , social isolation , and the demand for institutional care.
Aging resembles a developmentally regulated process that is tightly controlled by specific epigenetic modifications and age-associated methylation changes exist in human genome.
Aging results in increased rates of age related disorders like neurodegenerative diseases , cardiovascular diseases , diabetes , cancer , arthritis etc.
Aging results in pervasive declines in nervous system function.
Aging , screening , and more complex and costly treatments pose a problem of sustainability and selection of interventions to the regional oncology system.
Aging should not be viewed as a difficulty to definitive therapeutic option.
Aging showed statistically significant increased risk for AMD development in this study.
Aging significantly decreased Er in the hybrid layer and underlying dentin of control groups.
Aging significantly decreases the influenza vaccine-specific response as we and others have previously shown.
Aging significantly influences the corneal confocal microscopy parameters of individual corneal layers , except sub-basal nerve plexus and basal epithelium.
Aging significantly reduced lumbar lordosis by @number@.2° and sacrum orientation by @number@.6° during standing in all subjects.
Aging significantly reduces activated B cell ( CD19 + / CD69 + ) levels in males ( p < 0.005 ) .
Aging skeletal muscle responds to progressive overload through resistance training.
Aging skin is a leading concern of most men and women seeking cosmetic dermatologic consultation.
Aging societies face an increasing prevalence of neurodegenerative disorders for which no cure exists.
Aging Studies and Postcolonial Studies belong together in a rather fundamental way , given that they share profound theoretical roots and far-reaching critical perspectives.
Aging subjects additionally had measurements of platelet NO responsiveness and routine biochemistry.
Aging symptoms and sexual function were evaluated with the Aging Males ' Symptom Scale.
Aging , systemic diseases , and ischemic injury can disrupt these processes , resulting in a decline in overall BBB function and integrity.
Aging , taller height , protease inhibitor use , and female sex were significant RFs for PN / SPN.
Aging-the progressive decline of biological functions-is a universal fact of life.
Aging , trauma and occlusal overload are the main aetiological factors.
Aging turns out to be driven by sensing-signaling pathways ( such as the mTOR pathway ) .
Aging usually decreases the ability to understand language under difficult listening conditions.
Aging , vascular function , and exercise are thought to have a common link in oxidative stress.
Aging , viewed as an individual and social phenomenon , poses multiple challenges to healthcare providers who treat the elderly.
Aging , W-aging , and BT×W-aging improved myofibrillar ( sensory ) tenderness scores.
Aging was an independent predictor of an elevated presepsin value.
Aging was associated with a decrease in frontal lobe related functioning.
Aging was associated with a failure to upregulate SOD2 and a downregulation of PRX5 in muscle postexercise , irrespective of training status.
Aging was associated with increased prefrontal activation for retrieval of positive and negative memories , but this pattern was more widespread for negative memories.
Aging was associated with poorer glucose control ( p < 0.05 ) , independent of training.
Aging was negatively associated with MHO and positively with MUNO prevalence.
Aging was significantly associated with modification of excision efficiency for AP sites , uracil , Tg and 8oxoG.
Aging which varies among individuals , has been associated with the matrix metalloproteinase ( MMP ) @number@ and @number@ genes.
Aging with HIV has been associated with poorer cognitive outcomes compared to HIV-negative adults.
Aging with HIV poses unique and complex challenges , including avoidance of neurocognitive disorder.
Aging with intellectual disability has become an important topic in light of the significant increase in life expectancy of this population.
Aging women maintain thirst sensitivity to osmotic stimuli but lose some thirst sensitivity to changes in central body fluid volume.
Aging workers showed a poorer performance on a test of right-leg support ( p = 0.004 ) .
Aging , work fatigue , and exercise conditions were main related factors for qi deficiency syndrome ( P < 0.
Aging , worse KL , and cartilage and meniscus lesions were associated with higher quadriceps intraMF fraction.
A given reduction in CD4 count was associated with a greater reduction in haemoglobin and albumin concentrations among older people living with HIV.
AGK assembles with TIMM22 and TIMM29 and supports the import of a subset of multi-spanning membrane proteins.
AGK generates phosphatidic acid and lysophosphatidic acid , bioactive phospholipids involved in lipid signaling and the regulation of tumor progression.
A global cognitive ability measure was used as a continuous measure and according to tertile.
A Global Cognitive Function ( GCF ) score was derived from tests of speed , memory and executive function.
A global cognitive z score served as the summary cognition measure.
A global gene expression analysis with whole blood samples from the aged showed small but statistically significant differences depending on the time of sample collection.
A global increase in older people will also mean an increase in the numbers of lesbian , gay and bisexual people requiring residential support.
Agonist-evoked ATP release was accompanied by mucosal contractions.
A good anti-Aβ antibody response was found in the rabbit model.
A good correlation between the NIRS classification and the concentration of ellagitannins in red wine aging in contact with the classified staves was observed.
A good deal of influence in the Canadian long-term care sector rests with professionals such as provincial health administrators not employed in long-term care facilities.
A good head of hair is frequently present some time after ages @number@ to @number@ years.
A good inter- and intra-observer reliability was found for bone mineral density measurement of the coracoid process ( @number@ and @number@ respectively ) .
A good perfusion function would help to keep the bone health.
A good rat model that produces severe intrastriatal hemorrhage ( ISH ) mimicking human severe ISH is lacking.
A GPJEM with low , moderate , and high probability of exposure to demands and resources was developed.
A graded and statistically significant association persisted after adjusting for other cardiometabolic factors and also in time-dependent models.
A gradient in biomarker abnormalities was most pronounced in MENO , intermediate in PERI , and lowest in CNT ( p < 0.001 ) .
A gradient in the branching density was observed from the DEJ towards the pulp , independently of the anatomical location.
A ' gradual change management plan ' could assist older adults to adopt technologies more effectively.
A gradual decline in immune function , termed immunosenescence , and age-related changes in tissue structure influence the development of these disorders.
A gradual decline of oxygen and glucose supply to the brain during aging or hypoxia was manifested as a contributing factor to hypometabolism.
A gradual nephrons loss in aging kidneys causes them more susceptible to acute injury as well as fastens the progression of their chronic disease.
A grandmother hypothesis ( 8-12 ) may explain why greater longevity evolved in our lineage while female fertility still ends at ancestral ages.
A graph is then constructed by establishing a link between @number@ nodes if the difference in thickness between the nodes is below a certain threshold.
A graph-theoretic framework is used to guide analysis of functional MRI resting-state data and describe systems-level differences in connectivity of individual brain networks.
A great deal of progress has recently been made in understanding the genome-wide expression patterns , biogenesis , and regulation of circRNAs.
A great deal of research indicates that dysfunctional mitochondria are the primary site of reactive oxygen species ( ROS ) .
A great deal of work has been carried out on therapeutic potential of Ganoderma lucidum.
A greater decline at @number@ min for young women was only observed for ADC in the medial gastrocnemius.
A greater increase of CD4 ( + ) cell counts was associated with a greater reduction on the risk of progression to SILs.
A greater maximal moved distance score indicated a greater fall risk.
A greater number of bvFTD caregivers compared to SD reported negative aspects of sleep quality for themselves and used sleep medications more frequently.
A greater number of unique age-related CSIs was revealed when using smaller stimuli , particularly in the mid-periphery.
A greater proportion of one's amplitude of accommodation may be continuously exerted than previously suggested.
A greater proportion of the male village doctors were aging.
A greater understanding of these relationships may lead to identification of the underlying mechanisms in this important area of research.
A greater understanding of those factors can inform the development of activities for maintaining cognitive strength.
Agreeableness and openness were associated with better subjective mental health and physical health , respectively.
Agreeableness , indexed with a measure focusing on empathy , decreased in young adulthood and remained relatively unchanged thereafter.
Agreement about communication regarding QOL was modestly associated with surrogate knowledge of treatment goals.
Agreement about other ACP activities was not associated with knowledge.
Agreement across estimates was @number@ ( @percent@ CI @number@ @number@ ) .
Agreement between and within observers for physical examination items is variable.
Agreement between the manual and automatic methods was evaluated by using linear regression and Bland-Altman plots.
Agreement between the @number@ unawareness variables was moderate in Latin America and China but only slight in India.
Agreement between the two sides for discrete data was very good to excellent ( kappa , @number@.77-1 ) .
Agreement beyond chance was summarised using Kappa statistics and intra-class correlation coefficients.
Agreement level between patients ' and relatives ' ratings in CANE was moderate to low.
Agreement on the final radiographic outcomes was more uniform and acceptable for both shoulder and trauma surgeons.
Agreement on the indicators that constitute the cognitive reserve model is needed before testing possible interventions that may increase the reserve supply and improve cognition.
Agreement ( Range Menopause is characterized by the depletion of estrogen that has been proposed to cause oxidative stress.
Agreement was highest among \ "accumulation of deficits \ "-type FS , while accuracy was highest for multidimensional FS.
Agreement with individual ERA-12 items varied widely.
A grey literature search was performed using Google and Google Scholar.
A groundbreaking publication by Sinclair and coworkers has illuminated the pseudo-hypoxic state in aging and its reversibility.
A grounded theory study guided by symbolic interactionism was used to explore nursing practice with hospitalised older adults from a nursing perspective.
A grounded theory technique was used for the data analysis.
A group administered survey ( The Disaster Evacuation Survey ) included a total of @number@ questions.
A group-based model of trajectory analysis was applied with time-dependent and time-independent variables.
A group-based protein requirement was assessed by using a nonlinear mixed model of protein intake and L- [ 1-¹³C ] phenylalanine oxidation.
A group-based trajectory model identifies common trajectories.
A group-based trajectory modelling approach was employed to create SES trajectories.
A group from Chicago ( N = 60 ) was used for validation of associations and to explore the impact of angiotensin receptor blocker treatment.
A group of ~80 scientists met for three days of intense formal and informal exchanges.
A group of aged-matched women without any exercise training ( UN group ) were evaluated during the same period.
A group of clinicians was given the task of discussing the role of tissue engineering in the treatment of degenerative cartilage lesions in ageing patients.
A group of elderly subjects with a clear lens and normal vision served as the control group.
A group of enzymes which are referred to as enzymatic crystallins were proposed to contribute to corneal transparency in various animals.
A group of @number@ community-based , older adults ( aged 65-89 years ) wore an actigraph over two weeks.
A group of @number@ community-dwelling people and @number@ nursing homes residents were selected ( n = @number@ ) .
A group of @number@ individuals were interviewed during the third wave of the SABE study performed in Sao Paulo , SP , in @number@
A group of @number@ people over @number@ years in age were included in the study.
A group of @number@ subjects were interviewed during the third wave of the SABE study performed in Sao Paulo , in @number@
A group of @number@ women aged @number@ ± @number@ years was studied.
A group of @number@ young healthy observers was included as it has been reported that normal aging affects eye movements.
A growing body of evidence highlights the pathogenic significance of genetic interactions in the embryo and maternal effects that have a genetic basis.
A growing body of evidence indicates that oligomeric forms of Aβ play a critical role in disease causation.
A growing body of evidence is reporting that classical cardiovascular risk factors are potent predictors of several forms of dementia.
A growing body of evidences suggest that a high anticholinergic burden is associated with physical and cognitive impairment.
A growing body of evidence suggests that the cerebellum is involved in both cognition and language.
A growing body of evidence supports the central role of platelets in early events of tumorigenesis and metastasis.
A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects.
A growing body of literature provides evidence that the aging process may be accompanied by changes in metabolic supply and demand during muscle contractions.
A growing body of recent evidence , however , implicates FMOs in aging , several diseases , and metabolic pathways.
A growing body of research has examined how family dynamics shape residential mobility , highlighting the social-as opposed to economic-drivers of mobility.
A growing body of research suggests that meditation practices are associated with substantial psychological as well as physiological benefits.
A growing number of companies have started to plan ahead of the current demand of human resources.
A growing number of immune checkpoint inhibitor immunotherapy trials have been published with basic safety and clinical response data stratified by age.
A growing number of magnetic resonance imaging studies employ voxel-based morphometry ( VBM ) to assess structural brain changes.
A growing number of reports show that cytokines may specifically interact with neuronal channels regulating neuronal excitability , synaptic plasticity and responses to injury.
A growing number of studies have found a link between outdoor air pollution and cognitive function among older adults.
A growing population of informal dementia caregivers experience chronic stress associated with extraordinary demands of caring for a relative with dementia.
AG showed lower left ventricular twist than controls.
AGTR1 A1166C polymorphism was assayed by allele-specific oligonucleotide hybridization.
AG underwent the protocol in hot-spring water ( 36°C ) while LG did it in a land-based environment.
A habituation ( familiarization ) period is necessary for the Wii Agility test to avoid a systematic learning effect between successive test sessions.
A hallmark feature of cognitive aging is a decline in the ability to form new memories.
A hallmark of Alzheimer's disease ( AD ) brain is the amyloid β ( Aβ ) plaque , which is comprised of Aβ peptides.
A hallmark of contemporary culture is a preference for thermally processed foods , replete with pro-oxidant advanced glycation endproducts ( AGEs ) .
A hand search of JMIR Publications journals was also completed in @date@ .
A haplotype of two markers in the Lim3A regulatory region was significantly associated with variation in lifespan.
AHAP started in @date@ and @number@ participants had been seen by @date@ , the end of the baseline stage of this study.
A health care payer's perspective was applied in the economic evaluation.
A health promotion programme focusing on the meaning of everyday activities was implemented and evaluated to test its usefulness for community-dwelling seniors in the Netherlands.
A healthy baby with no mutated alleles was delivered based on prenatal diagnosis performed by genetic testing of amniocytes for the causative mutation.
A healthy life style includes appropriate utilization of medicines.
A healthy lifestyle score was computed by assigning @number@ point each for a medium or high adherence to the MedDietScore , non-smoking and physical activity.
A healthy proteome is essential for cell survival.
A heating duration experiment determined the nicotyrine to nicotine ratio ( NNR ) in particle phase as a function of the duration of e-cig activation.
A heavy but normal physiologic discharge can be determined by excluding other causes.
A heel cup with an arch support insole was provided.
A height range was determined by a histogram of height in each group.
A heterochromatic flicker photometry based instrument ( MPS @number@ ) was used to measure MPOD.
A heterozygous novel missense mutation in the PSEN1 gene c.1156T > A , altering phenylalanine to isoleucine at codon @number@ was identified.
A hierarchical cluster analysis was used to subgroup the different gait patterns based on spatiotemporal and kinematic parameters in the sagittal and frontal planes.
A hierarchical ranking was used to categorize diagnosis codes identified during ED visits into clinically meaningful categories to assess conditions for UC.
A high allostatic load is associated with increased risk of morbidity and mortality.
A high concentration of vitamin C and anthocyanins was found in the fruits.
A high correlation was demonstrated between the Ach index and cognitive function.
A high degree of genomic instability occurs as DNA double-strand breaks are introduced but not repaired , despite appropriate machinery.
A high degree of improvement was achieved in two to three treatments with no long-term sequelae.
A high degree of suspicion is required for the early diagnosis of pulmonary arterial hypertension and lymphocytic interstitial pneumonia , given their nonspecific manifestations.
A high dietary intake of fruit and vegetables has been shown to be protective for health.
A high educational level , a vegetable-based diet , and tea were protective factors for VD.
A higher age was associated with a higher coagulability but lower anxiety levels.
A higher birth rate in the first four months of the year was revealed , with the exception of February.
A higher BMI is also associated with a lower incidence of sarcopenia.
A higher compliance may be achieved by consideration of different residents ' characteristics.
A higher concentration of cases was observed in municipalities located along the western range of the state.
A higher conversion rate was observed in our experience for patients aged 65-79.
A higher DC indicates a more distensible vessel.
A higher delta change in serum calcium levels was associated with a decrease in renal function at @number@ months of cinacalcet treatment.
A higher EI was not significantly associated with a higher rate of local control on multivariate analysis.
A higher incidence of aspiration pneumonia was also observed in the alternative feeding group.
A higher intake of plant fat ( p = 0.018 ) was associated with a lower SRRC score.
A higher level of education was associated with a slower rate of decline ( estimate @number@ S.E. @number@ p < 0.018 ) .
A higher level of EHRA score was connected with a smaller degree of the acceptance of the illness p = @number@
A higher mean diffusivity causes a smaller signal-to-noise ratio and , thus , increases the measurement uncertainty.
A higher mean glycated haemoglobin value in @number@ was associated with a reduced probability of vaccination.
A higher mean pack year value was found in subjects with negative rather than positive hTERT expression ( P < @number@ ) .
A higher nasal eosinophils count was associated with AR and a lack of clinical response to antihistamines.
A higher nuclear color score correlated significantly with failure to measure the MPOD ( χ ( @number@ ) = @number@ P = @number@ ) .
A higher number of correct responses were observed on the adapted BNT than on the original BNT in all three education groups.
A higher occurrence of DNA aneuploidy ( particularly in smokers ' OPMDs ) was observed in patients characterized by involvement of a single oral subsite.
A higher PDMS-2 Visual-Motor Integration subscale score predicted a better WeeFIM score after home-based CIT ( adjusted R² = @number@ ) .
A higher percentage of communities with more than @number@ beds screened for depression compared with communities with 4 25 beds.
A higher proportion of depressed CDR @number@ subjects had CDR and functional decline than their non-depressed counterparts.
A higher proportion of patients in the CG had a history of heart failure and cerebrovascular disease.
A higher proportion of people in areas with a high prevalence of H pylori infection acquired gastric abnormalities.
A higher proportion of the elderly with intracapsular fractures were treated by replacement arthroplasty.
A higher proportion of type II fibers < 3 , 000 µm ( @number@ ) was observed in the old subjects.
A higher proportion of whites than blacks met targets , however defined.
A higher proportion of women and a longer history of urban dwelling were present in the older group.
A higher quantitative insulin sensitivity check index was associated with lower whole-body proteolysis rates.
A higher score improved overall survival in both Greek and non-Greek elderly reducing the risk of death by @percent@ after 5-7 years.
A higher social network degree , i.e. , more social connections , was associated with fewer diseases.
A higher WMH proportion , whether periventricular , subcortical , or lobar , correlated with reduced velocity ( P value < .001 ) .
A higher yield of biopsy was noted in subjects with asymmetric / multiple mononeuropathy compared with symmetric neuropathies ( @percent@ versus @percent@ ) .
A high-fidelity fluid-particle transport model was employed to simulate the multi-regime airflows and particle transport within the nasal-laryngeal airways.
A high-flavanol intervention was found to enhance DG function , as measured by fMRI and by cognitive testing.
A high frequency of fractures and increased adverse outcomes following a fracture were observed.
A high frequency of neurodevelopmental learning disability in primary progressive aphasia has been reported.
A high level of carotenoids can be achieved with a healthy diet rich , for instance , in fruit and vegetables.
A high likelihood of falling , in turn , is attributable to an ageing-related decline in physical functioning and general frailty.
A highly complex and heterogeneous molecular pathophysiology underlies diabetes-related bone disease , involving hormonal , immune , and perhaps genetic pathways.
A highly selective inhibitor of neutrophil elastase blocked decorin breakdown by proteases released from PMN cells.
A highly sensitive liquid chromatography-tandem mass spectrometry multimethod was developed that allowed us to quantitate @number@ protein modifications in normal and cataractous lenses , respectively.
A high number of specimens failed prematurely prior to testing when they were cleaned using @percent@ isopropanol.
A high proportion of the cardiovascular systems articles were on allogeneic transplants in a number of different species , including several autologous studies.
A high proportion of the old elderly group ( @date@ ) had a type II odontoid fracture.
A high statistically significant positive correlation was found between grading of solar elastosis in the photoaging group and COX-2 expression parameters.
A histological evaluation of peeling-induced skin changes in subcutaneous undermined preauricular facial skin flaps of nine patients was performed.
A history of chronic diseases was confirmed by the medical records of each participant.
A history of falls was associated a larger percentage of two postural adjustments , and a longer latency of foot liftoff.
A history of falls was collected at baseline and fall events were collected every @number@ months.
A history of previous falls , disability , and cognitive impairment had no effect on the program among the community-dwelling subjects in this study.
A history of \ "sensitive skin \ " was approaching statistical significance ( P = @number@ ) .
A history of stroke doubles the risk of incident dementia in the older population.
A history of substance disorders was also associated with significantly higher mtDNA copy numbers.
A hostile disposition and a perceived hostile social environment have a synergistic effect on current cigarette smoking for women.
A hot stupe was placed on the epigastrium of each elderly patient @number@ min after the postural change.
AHRS modules were carefully attached to the center plate of the Gimbal table and put through experimental static and dynamic conditions.
A hsCRP level in the high cardiovascular risk category was found in @percent@ of participants.
AHSP was analyzed as the total score of @number@ taste items ( T ) and @number@ smell items ( S ) .
A hypertensive status impairs endothelial dysfunction , which might deteriorate skeletal muscle if vascular angiogenesis is not maintained.
A hypogonadal state in aging men has deleterious effects.
A hypothesis is that ELF-EMFs could interfere with chemical reactions involving free radical production.
AI , CI , and histologic BPH were analyzed in a blinded fashion using a grading system ( 0-3 ) .
A idade apresentou associação positiva e o sexo masculino apresentou associação negativa com o recebimento de qualquer ajuda.
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AIM : A cross-sectional study to determine the caries experience characteristics and their relationship with aging.
AIM : Adequate nutritional intake is essential for pressure ulcer healing.
AIM : After both oral and intravenous glucose administration , peripheral insulin concentrations are lower in trained compared with untrained humans.
AIM : Age is an independent risk factor for acute kidney injury ( AKI ) .
AIM : Aging changes sleep patterns in most elderly people.
AIM : Aging is affecting health care all over Europe , but it is expected to have a much greater impact in Eastern Europe.
AIM : Aim of the study is to test the hypothesis that metabolic factors may independently affect motor function in obesity.
AIM : Aim of the study was to validate the Italian version of the Neuropsychiatric Inventory-Nursing Home ( NPI-NH ) .
AIM : Along with rapid aging , medical expenditure for older adults has been increasing in Japan.
AIM : Although recurrent tonsillitis can be the consequence of defects in immune system , the exact etiology of recurrent tonsillitis is not clear.
AIM : Analyse data on PRBC age to complications and outcomes in patients with SAH.
AIM : Aortic dilatation is a well-known phenomenon in the elderly.
AIM : A pen and paper Token Test utilizing binary scoring of accuracy-inaccuracy in responses evaluates linguistic functions including verbal comprehension.
AIM : A systematic literature review and meta-analysis were undertaken to investigate the effectiveness of person-centered care for people with dementia.
AIM : A systematic literature search was conducted using MEDLINE and ISI Web of Science.
AIM : Baby boomers are depicted as a cohort who will redefine the ageing process and reject segregated homes for older people.
AIM : Bioelectrical impedance analysis has been reported to have high reliability and accuracy in assessing body composition.
AIM : Cardiorespiratory fitness ( CRF ) is independently associated with a reduced risk of cardiovascular disease.
AIM : Chronic subdural hematoma ( CSDH ) is a very common condition seen usually in the later stages of life.
AIM : Colorectal cancer ( CRC ) is a major cause of cancer death worldwide.
AIM : Delirium is a common and severe complication among older hospitalized patients.
AIM : Dementia and cognitive impairment are important public health challenges to a rapidly aging country.
AIM : Denture-related stomatitis is a disorder that often affects denture wearers.
AIM : Depression and frailty are prevalent and burdensome in older age.
AIM : Diabetes is a serious global health problem.
AIM : Does supplementary home-based biofeedback improve FI and quality of life ( QOL ) ?
AIM : Elevation of homocysteine is associated with an increased risk for bone fractures.
AIM : Homocysteine ( Hcy ) is a sensitive marker of one-carbon metabolism.
AIM : In normal aging , subjective cognitive decline ( SCD ) might reflect personality traits or affective states rather than objective cognitive decline.
AIM : In this paper we aimed to systematically review the literature on physical activity's effect on depressive symptoms in Parkinson disease.
AIM : In this study we investigated common volumetric brain changes in both young and middle-aged StD patients.
AIM : It has been reported that many people with dementia require hospitalizations.
AIM : Manual wheelchairs are commonly prescribed for older adults in nursing homes ( NH ) .
AIM : Many previous studies have investigated older adults ' attentional preference toward different emotions.
AIM : Mesenchymal stem cells ( MSCs ) have large regenerative potential to replace damaged cells from several tissues along the mesodermal lineage.
AIM : mirror movements are a transient phenomenon during childhood , which decrease in intensity with motor development.
AIM : Modern office workers are often impacted by chronic neck / shoulder pain.
AIM : Most studies about the structures of the human skin have been on the general histologic features of the skin.
AIM : Mucormycosis is a fungal infection associated with high mortality.
AIM : New techniques for biological repair in the treatment of degenerative disc disease ( DDD ) have been developed recently.
AIM : Numerous geriatric patients develop colorectal disease.
AIM : NZ needs a surgical workforce with the capacity to meet the increasing health demands of an aging population.
AIM OF STUDY : Negotiations about problem definitions are a crucial part of psychotherapeutic and counselling work.
AIM OF STUDY : Working in second half of life is individually and socially important.
Aim of the present investigation was the assessment of magnitude and distribution of subjective menopausal complaints in the German population.
Aim of the present study was to determine whether measures body composition predict incident heart failure in older adults.
Aim of the present study was to evaluate whether ultrasound could be useful in the diagnosis of localized cervical pain.
Aim of the review is to provide an insight into gender differences of bladder control and bladder dysfunction.
Aim of the review To identify studies assessing the elderly's functional ability to manage their own medication.
AIM OF THE STUDY : To describe the pattern of errors at RCPM in subjects suffering from AD as compared with that of aMCI.
AIM OF THE STUDY : To explore the neuroprotective mechanisms of baicalin against cerebral ischemia reperfusion injury.
Aim of the study was to analyze and compare the usefulness of combination drugs therapy and monotherapy after a trial period of six months.
Aim of the study was to analyze temporal trends in prevalence of hyponatremia over four decades in different settings.
Aim of the study was to evaluate functional outcomes after ventral mesh rectopexy and conventional suture rectopexy.
Aim of this paper is to critically appraise the available guidelines on the non pharmacological management of BPSD.
Aim of this review is to discuss both molecular mechanisms associated with stem cell senescence and interventions that may attenuate or reverse this process.
Aim of this study is to report additional PDCD10 / CCM3 families poorly described so far which account for 10-15% of hereditary cerebral cavernous malformations.
Aim of this study was to assesses the extent of differences between cells from donor with adenomyosis and cells from healthy donor.
Aim of this study was to assess the best treatment in elderly with multiple intracranial aneurysms ( MIA ) .
Aim of this study was to assess the role of CTC in excluding a colorectal cancer ( CRC ) in older symptomatic patients.
Aim of this study was to evaluate the discriminative capacity of the FP and compare it with a modified version including only anamnestic information.
Aim of this study was to evaluate whether non-insulin-dependent diabetes mellitus ( NIDDM ) increases the risk of LJM in elderly subjects.
Aim of this study was to identify subtypes by a data-driven approach applied to a broad spectrum of motor and nonmotor features of PD.
Aim of this study was to investigate the impact of aerobic training on diastolic function with increasing age with speckle tracking echocardiography.
AIM : Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea.
AIM : Oxidised low-density lipoprotein ( LDL ) is considered a risk marker for cardiovascular disease.
AIMP3 / p18 overexpression is sufficient to induce the cellular senescence phenotypes with compromised clonogenicity and adipogenic differentiation potential.
AIM : Pharmacoeconomic cost-effectiveness analysis of two different dosage regimens of levofloxacin in the treatment of acute lower respiratory tract infection in elderly patients.
AIM : Physical activity ( PA ) patterns of retirement village residents were investigated using self-report and objective measures.
AIM : place of death is an important component of the quality of a person's death.
AIM : Previous research has identified how newly diagnosed prostate cancer affects men's daily lives , including daily activities and existential issues.
AIM : Primitive reflexes can reappear with diseases of the brain , particularly those affecting the frontal lobes.
AIM : Published data on thrombin generation variables and their correlation with thromboelastometry in the healthy population are scarce.
AIM : Pulse wave velocity does not correlate to age in the upper limb but in the aorta and lower limb.
AIM : Pulse wave velocity ( PWV ) , an estimate of arterial stiffness , is an important predictor of cardiovascular risk.
AIM : Reports of the outcomes of syncope assessment across a broad spectrum of ages in a single population are scarce.
AIM : Reverse cholesterol transport ( RCT ) is a critical mechanism for the anti-atherogenic property of HDL.
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AIMS : Acquired hearing loss is a worldwide epidemic that affects all ages.
AIMS : Ageing-related cardiac disorders such as heart failure and atrial fibrillation often present with intracellular calcium homeostasis dysfunction.
AIMS : A growing and aging population is associated with an increased incidence of cancer.
AIMs also inhibited EMT of cancer cells.
AIMS : an association between T2DM and cognitive impairment has been reported among Western populations , but data are limited in other settings.
AIMS AND BACKGROUND : Abruzzo and Molise are two regions located in the south of Italy , currently without population-based cancer registries.
AIMS AND BACKGROUND : Model-based estimates and projections of epidemiological indicators related to cancer are important tools to support public health policies and planning.
AIMS AND BACKGROUND : The regional health care system of Liguria caters for a resident population which is among the oldest in Europe.
AIMS AND OBJECTIVES : To evaluate nurses ' knowledge of guidelines for preventing infections associated with peripheral venous catheters.
AIMS : An open-label prospective study was carried out to evaluate this HA filler's performance in correcting facial defects due to volume loss.
AIMS : Anterior mesh rectopexy is a novel surgical technique for the treatment of complete rectal prolapse , a common disorder in female elderly patients.
AIM : Sarcopenia and sarcopenic obesity are significant associative factors for functional impairment related to aging.
AIM : Sarcopenia can cause varying physical function disorders , including dysphagia.
AIM : Sarcopenia causes a decline in physical performance and decreased quality of life.
AIM : Sarcopenia is a well-recognized geriatric syndrome , which is associated with a variety of adverse outcomes.
AIMS : Arterial stiffening may lead to hypertension , greater left ventricular after-load and adverse clinical outcomes.
AIMS : Biologically active phenomena , triggered by atherogenesis and inflammation , lead to aortic valve ( AV ) calcification.
AIMS : B-type natriuretic peptide ( BNP ) and C-reactive protein ( CRP ) predict atrial fibrillation ( AF ) risk.
AIMS : Carotid-cavernous fistulas ( CCFs ) are abnormal communications between the carotid arterial system and the cavernous sinus that occur mainly in elderly.
AIMS : Clonidine is used for sedation in the paediatric intensive care unit.
AIMS : Coronary artery calcification ( CAC ) is a strong predictor of atherosclerotic cardiovascular disease ( CVD ) .
AIMS : C-peptide secretion is currently the only available clinical biomarker to measure residual β-cell function in type @number@ diabetes.
AIMS : Defining the effects of topic alpha-tocopherol acetate administration on nasal mucosa healing after endoscopic sinus surgery in CRS of elderly patients.
AIM : Sense of autonomy - the possibility to choose and decide - is one of the markers of positive and active aging.
AIM : Several operative definitions and screening methods for sarcopenia have been proposed in previous studies ; however , the opinions of researchers still differ.
AIMS : Exercise training ( ET ) has been variably associated with body composition changes among persons with type @number@ diabetes ( T2DM ) .
AIMS : Few data regarding prevalence of and risk factors for poor bone health in aging individuals with long-standing T1D are available.
AIMS : Heart failure ( HF ) continues to be a leading cause of morbidity and mortality in industrialized countries.
AIMS : Here , we aimed to investigate alexithymia features in people with prominent clinical memory complaints.
AIMS / HYPOTHESES : Obesity is associated with decreased insulin sensitivity ( IS ) and elevated plasma branched-chain amino acids ( BCAAs ) .
AIMS / HYPOTHESIS : Biological ageing of the immune system , or immunosenescence , predicts poor health and increased mortality.
AIMS / HYPOTHESIS : Mitochondrial respiration has been linked to insulin resistance.
AIMS / HYPOTHESIS : Muscle mitochondrial function can vary during fasting , but is lower during hyperinsulinaemia in insulin-resistant humans.
AIMS : In diabetes , endothelial damage promotes macroangiopathy and endothelial regeneration is impaired , owing to reduced endothelial progenitor cells ( EPCs ) .
AIMs inhibited glycogen synthase kinase-3β phosphorylation and β-catenin expression that are invovled in EMT.
AIMs inhibited the phosphorylation of Akt and EGFR , but the inhibitory effect on Akt was not derived from EGFR.
AIMS : Intravenous transplantation of bone marrow mesenchymal stem cells ( BMSCs ) had been documented to improve functional outcome after ischemic stroke.
AIM : Slow gait speed has been associated with mortality , poor physical function and disability in older people.
AIMS : Low-temperature degradation ( LTD ) of yttria-stabilized zirconia can produce increased surface roughness with a concomitant decrease in strength.
AIMS : Microglia are the resident immune cells in the central nervous system , originating from haematopoietic-derived myeloid cells.
AIMS : Non-response to population surveys is a common problem in epidemiological and public health research.
AIMS OF THE STUDY : Earlier P300 studies were conducted when the prevalence of dementia with Lewy Bodies ( DLB ) was unknown.
Aims of this study were to evaluate and compare the oocyte ultrastructure after RA and IvA.
AIM : Some elderly patients with incontinence require the care of third parties , known as caregivers.
AIMS : One-eighth of young adults in the United States report that their biological father has ever been incarcerated ( FEI ) .
AIMS : Our aim was to clarify the association between type @number@ diabetes and the risk of low muscle mass in older adults.
AIMS : Our aim was to retrospectively evaluate the impact of age on patient outcomes following parathyroidectomy for primary hyperparathyroidism.
AIMS : Reactive oxygen species ( ROS ) play a pivotal role in different pathologic conditions , including ischemia , diabetes , and aging.
AIMS : Risk models that use a single aortic diameter threshold have failed to successfully predict acute type B aortic dissection ( TBAD ) .
AIMS : Studies about sarcopenia in Asia are fewer , and started later than in Europe and America.
AIMs suppressed the invasion of A549 cells in a dose-dependent manner.
AIMS : Tau is a microtubule-binding protein facilitating the stability of the cytoskeleton.
AIMS : Tendons are crucial for optimal muscle force transfer and subject to changes with aging which may impair functional ability of elderly individuals.
AIMS : The aim of the study was to assess the occurrence and intensity of musculoskeletal pain as a risk factor for reduced work ability.
AIMS : The aim of this study was to assess the prevalence of fecal incontinence and the associated risk factors in the elderly outpatients.
AIMS : The aim of this study was to determine the safety and efficacy of ultrasound-guided IJV CVP placement in elderly oncologic patients.
AIMS : The aim of this study was to examine the association of PM composition with cardiovascular mortality.
AIMS : The aim of this study was to examine the influence of maternal smoking during pregnancy on retinal vessel calibers in children.
AIMS : The aim of this study was to identify seminal Australasian Journal on Ageing papers published over @number@ years through a Delphi consensus process.
AIMS : The mechanisms underlying numerous biological roles of hydrogen sulfide ( H2S ) remain largely unknown.
AIMS : The present study evaluated the association between cognitive function and left ventricular systolic function in hemodialysis patients.
AIMS : The purpose of the study was to assess the hemorheological parameters levels in SCI patients.
AIMS : The purpose of this study is to investigate correlations between periprosthetic BMD and the factors affecting osseointegration.
AIMS : The purpose of this study was to determine whether volatile organic compounds specific to Pseudomonas aeruginosa could be detected in clinical sputum specimens.
AIMS : The purpose of this study was to examine relationships among gait and mobility under single and dual task conditions in older adults.
AIMS : The purpose of this study was to explore clinical markers reflecting developmental changes in drug clearance by preterm infants.
AIMS : Therefore , the harmful effects of UVA and strategies to reduce it have been consistently investigated.
AIMS : The sporadic and late-onset form of Alzheimer's disease ( AD ) constitutes the most common form of dementia.
AIMS : The underlying mechanism of myocardial dysfunction in patients with type @number@ diabetes mellitus ( T2DM ) is unclear.
AIMS : This review aims to describe and analyze the main items that use this method to assess physical activity.
AIMS : This study aimed to investigate whether repeated lifestyle interventions lead to progressive weight loss or to weight cycling.
AIMS : This study aims to assess the impact of frailty on coagulation function and on response to warfarin.
AIMS : This study aims to elucidate the age-dependent change of cuticle and its effect on hair properties.
AIMS : This study investigated the effect of GBE on spatio-temporal gait parameters of MCI patients while walking under single and dual-task conditions.
AIMS : This study investigated whether a grafted aged donor liver can be rejuvenated in a pediatric recipient.
AIMS : This study's objective was to apply Cox regression for recurrent events to identify factors associated with injurious falls in the youngest-old.
AIMS : This survey aimed to identify nutritional deficits affecting Bedouin children as they enter school age and illustrate their families ' dietary consumption patterns.
AIMS : to assess and compare nutritional status and functional capacity of elderly goers of groups for guided physical activity or for guided recreational activities.
AIMS : To assess the potential association between vision and cognition in an ambulatory older population.
AIMS : To assess the prevalence of fecal incontinence ( FI ) and associated factors in older adults.
AIMS : To compare the CV risk pattern in two elderly cohorts living in North-East Italy.
AIMS : To compare the pragmatic and conventional diagnoses in terms of etiologic subtyping of MCI.
AIMS : To establish self-rated health , health-related behaviours and health conditions of Maori and non-Maori in advanced age.
AIMS : To estimate intrasession reliability and agreement of an active-active JPS test for hip flexion / abduction and knee flexion in healthy older adults.
AIMS : To estimate the comparative mortality risks of commonly prescribed antipsychotic agents in older people living in the community.
AIMS : To evaluate a high-energy protocol with combined bipolar radiofrequency and infrared light energies for improvement in photoaged facial skin.
AIMS : To evaluate clinical and surgical outcomes of surgically treated patients with FFP.
AIMS : To evaluate current in-market perceptions of the aesthetic result and use of Voluma.
AIMS : To evaluate the complication rate differences between elderly and younger patients who receive a permanent pacemaker implantation.
AIMS : To evaluate the feasibility and the efficacy of the application of robotic surgery in elderly patients affected by colorectal diseases.
AIMS : To evaluate the relationship between the metabolic syndrome and sexual function and to identify the factors associated with poor sexual function.
AIMS : To examine direct and indirect pathways between visual and cognitive function in advanced age.
AIMS : To examine the association between diabetes and disability in older Australians and to identify factors that explain this association.
AIMS : To examine the prevalence of cognitive impairment in a Spanish elderly population and to analyse its association with some social and medical factors.
AIMS : To explore nurses ' perspectives on how leaders influence function-focused care , defined as care that preserves and restores older people's functional abilities.
AIMS : To explore perspectives of three groups concerning transfers from aged care facilities to emergency departments.
AIMS : To further investigate the antineuroblastoma effect of rutin which is a type of flavonoid.
AIMS : To identify potential treatment needs of this population , a city-funded needs assessment was conducted.
AIMS : To identify the cause of increased ALP in postmenopausal women.
AIMS : To investigate long-term outcomes and identify predictors of sustained response in intestinal BD patients receiving infliximab ( IFX ) treatment.
AIMS : To investigate task demands and work ability in merchant seamen at sea and to identify factors predicting work ability.
AIMS : To investigate the association between endogenous testosterone levels and psychological health symptoms in men from a general population.
AIMS : To investigate the economic and social impact that proximal humerus fragility fractures may have on an older population.
AIMS : To investigate the efficacy of early hemicraniectomy in patients older than 60-years with malignant MCA infarcts.
AIMS : To investigate the excess mortality registered in the Veneto Region ( Northern Italy ) in @number@
AIMS : To investigate the relationship between volition , physical activity and weight loss maintenance.
Aims : to investigate whether vascular disease burden affects the association between depression and executive dysfunction differentially by age.
AIMS : To know the organization of internal medicine departments ( IMD ) and the opinion of their heads of department.
AIMS : To provide evidence that sodium salicylate ( SS ) obtained from neutralization of @percent@ SA by sodium hydroxide can deliver significant anti-aging benefits.
AIMS : To study the association between orthostatic hemodynamics and incident mortality in The Irish Longitudinal Study on Ageing ( TILDA ) .
AIMS : To study the feasibility of in situ penile progenitor cell activation by Li-ESWT.
AIMS : To test the hypothesis that chocolate consumption is associated with a lower risk of heart failure ( HF ) .
AIM : Studies indicate that women born small for gestational age ( SGA ) have impaired ovarian function.
AIMS : Type @number@ diabetes , hyperinsulinemia , and insulin resistance are associated with cognitive impairment.
AIMS : Type @number@ diabetes ( T2DM ) is associated with cognitive impairment.
AIMS : Very little data are available on the physical requirements for drumming and the potential health benefits of particularly djembe drumming.
AIMS : We aimed at determining the effect of BMI on functional health among older Germans longitudinally.
AIMS : We aimed to determine differences in demographic and behavioral profiles associated with HCC in HCV + patients in China and the USA.
AIMS : We aim to identify previously undefined SWT association factors in community-dwelling elderly people.
AIMS : We analyse the outcomes and the costs of the TPI in protecting low colorectal anastomosis in elderly , compared to the CLI.
Aims. We analyzed the effects of normalization of plasma testosterone ( T ) in LOH men.
AIMS : We evaluated the associations of diabetic complications and underlying pathology with daily walking activity in type @number@ diabetic patients without manifest mobility limitations.
AIMS : We examined the individual association between body mass index ( BMI ) and cognitive function among the very elderly.
AIMS : We explore home care nurse decision-making about the need for and amount of service by clients and families at the end of life.
Aims : We investigated whether traffic-related air pollution and noise are associated with incident hypertension in European cohorts.
AIMS : We provided a complete review of old and very old patients undergoing robot-assisted surgery for oncologic and general surgery interventions.
AIMS : We tested the association between social network characteristics and the number of chronic diseases in the elderly.
AIMS : With the advent of climate change , it is important that strategies be put in place to minimise the effects of heat.
AIM : Symptoms of late-onset hypogonadism ( LOH ) are often unspecific , and the existence of a male climacteric has been much debated.
AIMS : β-amyloid ( Aβ ) plaques are a key feature of Alzheimer's disease pathology but correlate poorly with dementia.
AIM : The age-dependent loss of skeletal muscle mass is highly concerning in diverse aging populations.
AIM : The aim of the present study was to delineate how age-related deterioration affects the handwriting of healthy elderly ( HE ) subjects.
AIM : The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients.
AIM : The aim of the study was to define the optimal technique of parathyroidectomy in elderly patients with secondary hyperparathyroidism.
AIM : The aim of the study was to describe the ontogeny of AMH secretion through life in healthy males.
AIM : The aim of the study was to examine the factor structure of the Chinese General Self-Efficacy Scale and gender invariance in the structure.
AIM : The aim of this research is to contribute new data related to the incidence of essential hypertension in elderly patients with metabolic syndrome.
AIM : The aim of this review is to describe the principal factors and mechanisms involved.
AIM : The aim of this study is to analyse the patients ' self-recorded data on weight and compare them according to hypertension and diabetes.
AIM : The aim of this study is to examine population-based utilization and impact of testosterone replacement therapy in men with prostate cancer.
AIM : The aim of this study is to gain insight into the needs of outpatients with late-life depression.
AIM : The aim of this study was to assess how the allergic sensitization pattern associates with asthma , rhinitis and their multimorbidity.
AIM : The aim of this study was to determine if aging is a factor that increases the intraoperative complication rate during phacoemulsification surgery.
AIM : The aim of this study was to establish the maximal heart rate ( HRmax ) -age relation with minimal error rate.
AIM : The aim of this study was to identify factors connected with positive life orientation among home-dwelling older people.
AIM : The aim of this study was to investigate the clinical efficacy of a PEMF device for management of knee osteoarthritis in elderly patients.
AIM : The aim of this study was to investigate the possible risk factors related with osteoporosis in women with spontaneous menopause.
AIM : The aim of this systematic review was to consider current evidence for an association between dairy intake and cognitive functioning.
AIM : The aim was to compare persistence , adherence , and switching between donepezil , galantamine , oral rivastigmine , and rivastigmine patch.
AIM : The benefits of Transition Care Programs ( TCPs ) for patients with cognitive impairment are not well established.
AIM : The elderly are the major population receiving the implantation of a permanent pacemaker ( PPM ) .
AIM : The evidence for self-management programmes in older adults varies in methodological approaches , and disease criteria.
AIM : The Frailty Index ( FI ) summarizes differences in health status within individuals , and the determinants of health drive that variability.
AIM : The large diffusion of venous disease ( CVD ) has been confirmed by several epidemiological studies in Europe and the USA.
AIM : The management of severely agitated elderly patients is not easy , and limited guidelines are available to assist practitioners.
AIM : The NRG1-ERBB4 neurotransmitter signaling pathway plays a key role in the pathogenesis of schizophrenia ( SZ ) .
AIM : The objective of this study was to assess the effect of age on vascular reactivity in patients with Type @number@ diabetes.
AIM : The optimal treatment for elderly glioblastoma patients is unclear.
AIM : The orexigenic hormone , ghrelin , is linked to learning and memory in animal studies.
AIM : The present study aimed to evaluate age-related changes in skeletal muscle mass among community-dwelling middle-aged and elderly Japanese.
AIM : The present study evaluated the association between changes in physical functioning and a variety of factors in an older population in Taiwan.
AIM : The prevalence of endocrine abnormalities in two different cohorts from the general and the symptomatic populations of Florence was compared.
AIM : The purpose of this exercise is to ascertain information about the organization of haemophilia care and treatment availability at national levels.
AIM : The purpose of this study is to explore how the phenomenon of dementia is perceived in ethnically diverse groups and cultures.
AIM : The purpose of this study was to demonstrate whether diabetic complications influence the sleep quality and depression in elderly patients.
AIM : The purpose of this study was to explore the effects of three commonly used positions on grip strength measurement in older people.
AIM : The purpose of this study was to illuminate the experiences of older adults ' return to leisure activities , following rehabilitation , post-stroke.
AIM : Therefore the present study examined the content and face validity , comprehensibility and interpretability of MAPDAQ-G in a Swiss context.
AIM : There have been no previous studies of quality of life ( QOL ) in older adults in Macao.
AIM : The sacral canal has been frequently used as \ "a passage \ " for minimally invasive diagnostic and therapeutic procedures for spinal diseases.
AIM : The study evaluated the relationship of extracellular matrix and renin angiotensin system with myocardial dysfunction in Type @number@ diabetes mellitus.
AIM : The transgender community has long been marginalized in society.
AIM : The use of anticholinergic drugs had been strongly linked to adverse health outcomes among older adults , especially in cognitive impairment or dementia.
AIM : The use of fluoride-releasing materials could be compromised due to aging and might also be influenced by other ordinary sources of fluoride.
AIM : This analysis sought to define the concept of individualized aging.
AIM : This article attempts to describe the aging process of the vocal folds and the main features of the aged voice.
AIM : This article examines whether neurocognitive deficits or age prevents people with borderline personality disorder from being considered responsible and competent.
AIM : This investigation aimed to assess the independent effects of antioxidant vitamins on tHcy in elderly people.
AIM : This paper explores age- and gender-specific changes in Doppler echocardiographic index-E ' of left ventricular diastolic function.
AIM : This paper is a report of an analysis of the concept resilient ageing.
AIM : This pilot study was designed to evaluate the efficacy and safety of ashwagandha ( Withania somnifera ( L. )
AIM : This research evaluated the effect of a topical serum formulation containing salicin at @percent@ on the visible signs of skin aging.
AIM : This study aimed to evaluate the nutritional status of elderly individuals living alone and with their families.
AIM : This study aimed to systematically review randomized controlled trials that examine whether VBF training is effective in improving balance in an elderly population.
AIM : This study aims to evaluate the efficacy and safety of mucosectomy in elderly patients considering the predictive value of submucosal infiltration.
AIM : This study aims to investigate the impact of anxiety on quality of life ( QOL ) in older people with mental disorders.
AIM : This study assessed the effects of ECG spectral entropy on obstructive sleep apnea / hypopnea syndrome ( OSAHS ) depending on age.
AIM : This study investigated the effects of ageing on the excitability of soleus homonymous Ia afferents and corticospinal pathways during bipedal upright standing.
AIM : This study sought to compare the cost-effectiveness of initial EUS or MRCP in patients with suspected CBD stones.
AIM : To analyse the impact of octogenarian donors in liver transplantation.
AIM : To assess systematically how age affects the prevalence of GERD and its oesophageal complications.
AIM : To assess the association between thiamin concentration , frusemide use , and renal function in older adults.
AIM : To assess the cross-sectional prevalence of and characteristics associated with sexual activity and physical tenderness in community-dwelling older adults.
AIM : To assess the histological changes that occur after methyl aminolevulinate ( MAL ) plus red-light therapy for facial photodamage.
AIM : To assess the relationship between perceived social control / personal control and functional health status among older adults in rural and urban Taiwan.
AIM : To assess the relationship between repolarization variables and arterial function.
AIM : To characterize the histopathologic specifications of non-alcoholic steatohepatitis ( NASH ) according to age and gender.
AIM : To characterize the periprocedural course of patients with primary osteolysis syndrome undergoing procedures that require anesthesia care.
AIM : To compare executive and general cognitive functioning in patients with FTD and in patients with schizophrenia in later life.
AIM : To compare results of trastuzumab-emtansine ( T-DM1 ) treatment in our clinical practice with data from phase III clinical trials.
AIM : To compare the diagnostic validity of NIA-AA criteria , for AD CSF biomarkers , with our own new criteria.
AIM : To compare verbal working memory with visual and spatial working memory in young and older adults.
AIM : To conduct item analyses and reduction , evaluate the psychometric properties of the HIS-Q-SF , and provide guidance on score interpretation.
AIM : To describe a research protocol designed to promote nutritional self-care in older people.
AIM : To describe short-term mortality among residential aged care ( RAC ) residents in Auckland , New Zealand.
AIM : To describe the experience of family caregivers of terminally ill people of the Carer Support Needs Assessment Tool intervention in home-based palliative care.
AIM : To describe the incidence or remission and biopsychosocial predictors of erectile dysfunction ( ED ) and low sexual desire ( SD ) .
AIM : To describe the prevalence and correlates of alcohol consumption and tobacco smoking among older Australian men.
AIM : To determine how the healthy aging affects to the different attentional networks.
AIM : To determine if ED is associated with depressive symptoms in men with prostate cancer.
AIM : To determine the accuracy of self-reported anthropometric measurements in older Australian adults 60-70 years.
AIM : To determine the contribution of the complementary feeding nutrients to the estimated total nutrient intake in Guatemalan infants.
AIM : To determine the viscoelastic properties of fresh human lenses obtained from cadavers under @number@ years of age.
AIM : To determine whether cynicism changes over time as a function of job change for nurses with high and low intentions to leave.
AIM : To determine whether dynamic DNA methylation changes in the human placenta can be used to predict gestational age.
AIM : To determine whether self-perceived driving confidence levels are lower in the post-stroke driving population than their aged-matched non-stroke driving peers.
AIM : to develop a clinical protocol to identify healthy older people living in the community and study their clinical , laboratory and functional characteristics.
AIM : To develop a home nursing quality scale and to evaluate its psychometric properties.
AIM : To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype ( SASP ) .
AIM : To develop a simple screening test to identify older adults at high risk for sarcopenia.
AIM : To estimate age-specific progression and regression of ED severity among subjects with at least mild self-reported ED.
AIM : To estimate the impact of various factors on the thyroid RAIU.
AIM : To evaluate ethnicity-specific differences in GC incidence and survival in the USA.
AIM : To evaluate habitual macronutrient intake and its association with common cardiovascular risk factors in Brazilian elderly women.
AIM : To evaluate heuristics ( rules of thumb ) for recognition of undetected vision loss in older patients in primary care.
AIM : To evaluate human gastric submucosal vascular dysfunction and its mechanism during the aging process.
AIM : To evaluate postmenopausal women's perceptions of VVA and treatment options for symptoms in the Women's EMPOWER survey.
AIM : To evaluate relationships between TL , CVR and inflammation markers in CS.
AIM : To evaluate the associations between refraining from buying prescribed medications and selected factors among older persons.
AIM : To evaluate the contribution of multimorbidity to OxS in LOAD and mild cognitive impairment ( MCI ) .
AIM : To evaluate the effect of a singing program developed specifically for older community-dwelling people on measures of health and well-being.
AIM : To evaluate the feasibility , efficacy , and safety of laparoscopic surgery for benign gynecological disease in women over @number@ years old.
AIM : To evaluate the impact of MS on sexual function in middle- to old-aged women.
AIM : To evaluate the possible effect of OP on the femoral cartilage thickness in female patients with knee OA.
AIM : To evaluate the prevalence and risk factors of gout and hyperuricemia in an elderly community cohort in Beijing.
AIM : To evaluate the prevalence of recurrent falls and their risk factors among older men living in the Veterans Homes in Taiwan.
AIM : To examine associations of sex hormones and cognitive function among older adults ≥65 years old.
AIM : To examine healthcare assistants ' ( HCAs ) attitudes towards older people in long-term care settings and their knowledge of ageing.
AIM : To examine lesbian and gay people's expectations of support , socialising and cohabitation in older age.
AIM : To examine the association between metabolic syndrome ( MetS ) and renal function in older Koreans.
AIM : To examine the gender differences in CO ( @number@ ) R in children during sevoflurane anesthesia.
AIM : To examine the literature on the impact of the discharge experience of patients with dementia and their continuity of care.
AIM : To examine the psychometric testing and clinical application of the Chinese version of the Resilience Scale ( RS ) in Chinese older people.
AIM : To examine the relationship between retinal vascular morphology and cognitive abilities in a narrow-age cohort of community-dwelling older people.
AIM : To examine the relationships between two epigenetic clocks , aging and exceptional longevity.
AIM : To explore medical decision making in octogenarians having cardiac surgery.
Aim : To explore the ability of Modified Early Warning Score ( MEWS ) to predict the in-hospital mortality in septic patients admitted to MWs.
AIM : To explore the everyday experiences of older adults serving as primary informal caregivers to significant others.
AIM : To explore the relationship between the anatomical site of peripheral venous catheterization and risk of catheter-related phlebitis.
AIM : To explore the usefulness of carotid ultrasound examination as a marker of aging and predictor of disability among older people.
AIM : To find a screening test able to differentiate CRI from the decrease in GFR normally associated with the renal ageing process.
AIM : To identify family physicians ' perception of the primary care collaborative memory clinic ( PCCMC ) care model.
AIM : To identify lifestyle factors associated with healthy aging in middle-aged and older Australian men.
AIM : To identify the efficacy of retinyl retinoate as an anti-aging agent of cosmetics in treating females over @number@ years old with periorbital wrinkles.
AIM : To improve self-management among patients with type @number@ diabetes incorporating CHWs as members of a clinical team.
AIM : To inform practice , service development and further research on ageing drug users.
AIM : To investigate and characterize the effect of age on apparent diffusion coefficient ( ADC ) values in normal spleen.
AIM : To investigate auditory processing of aged people with no hearing complaints.
AIM : To investigate contrast-enhanced ultrasound ( CEUS ) findings in portal venous system aneurysms ( PVSAs ) .
AIM : To investigate factors associated with the quality of life of nursing home residents to inform care management policies and service delivery.
AIM : To investigate how self-reported PLO changed among home-dwelling people from age @number@ to @number@ and @number@ years.
AIM : To investigate longevity-associated genes based on a comparison between dead and surviving populations.
AIM : To investigate processes at the end of life for patients who died in a subacute evaluation and management facility for older people.
AIM : To investigate the age-related changes in general and sexual health in middle-aged and older men from different countries of the European Union.
AIM : To investigate the association of fall risk with comorbidities and medications in geriatric outpatients in a cross-sectional design.
AIM : To investigate the associations between medication use and functional dependence in Chinese older people living in a rural community.
AIM : To investigate the differences in the clinical presentations and the management of AIH in the elderly and the younger patients.
AIM : To investigate the functional effects of abnormal esophagogastric ( EGJ ) measurements in asymptomatic healthy volunteers over eighty years of age.
AIM : To investigate the incidence and risk factors for pneumonia after endoscopic resection ( ER ) for gastric neoplasm.
AIM : To investigate the mechanical and chemical alterations of Invisalign appliances after intraoral aging.
AIM : To investigate the prevalence of absent frontal sinuses in dry skulls with metopism.
AIM : To investigate the relationship between anticholinergic drug use and one-year outcome of elderly patients hospitalised via the emergency department.
AIM : To investigate the relationship between circulating sex hormone levels and subsequent mortality in disabled elderly.
AIM : To investigate the relationship between physical function , mortality and autonomic nervous activity measured by heart rate variability of elderly in long-term care.
AIM : To investigate the relationship of the ovarian reserve to the levels of adipokines and sex hormones in reproductive-aged women with abdominal obesity.
AIM : To investigate the risk of developing Alzheimer's disease ( AD ) in patients undergoing ADT for prostate cancer.
AIM : To investigate whether AOx could improve the protection provided by a broad-spectrum sunscreen ( SS ) preparation.
AIM : To investigate whether stages of women's life characterized by different levels of E2 influence OS.
AIM : To investigate whether there is a birth cohort phenomenon for subjects with IBS.
AIM : To investigate whether there is a discriminatory testosterone level below which the CVD risk increases.
AIM : To look closely and carefully at several aspects of the way in which DSM-5 defines personality disorders relating to older persons.
AIM : To outline the importance of understanding quality of life ( QOL ) in people with dementia living in long-term care.
AIM : To present alternative stories of ageing that countered the prevailing negative stereotypes of older people by interviewing centenarians about their lives.
AIM : To prospectively investigate whether VE is associated with an increased risk of type @number@ diabetes in a Danish population.
AIM : To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation.
AIM : To report the incidence , clinical features and outcomes of gastrointestinal ( GI ) involvement in Behcet's disease ( BD ) .
AIM : To reveal nursing home employees ' views on dying and death among older people they cared for.
AIM : To review the literature on factors influencing patient participation in care with a particular focus on the perspective of older people.
AIM : To study longitudinal changes in optic nerve head ( ONH ) topography in healthy volunteers.
AIM : To study the changes in skin microrelief and periocular wrinkles during the aging process.
AIM : To study the empathic response in two groups of older people and their relationship to emotional intelligence and moral judgment.
AIM : To study the impact of aging on DNA methylation and mRNA expression in human liver.
AIM : To study the prognosis of patients with newly diagnosed Type @number@ diabetes in primary care in relation to their baseline C-peptide concentration.
AIM : To systematically review evidence on the efficacy and safety of mirodenafil treatment in erectile dysfunction ( ED ) from randomised controlled trials.
AIM : To validate the “Successful Aging Inventory” ( SAI ) in Chilean older people.
AIM : To verify narrative and pause duration , number of words and interlocutor's interventions in the oral narratives of children with typical development.
AIM : We aimed to determine whether there was a Blue Zone , an area characterized by extreme longevity , in Menorca , Spain.
AIM : We evaluated the prognostic value of vasohibin-1 ( VASH1 ) expression in head and neck squamous cell carcinoma.
AIM : We explored the association between family functioning and cognitive impairment in the very elderly aged 90-108 years.
AIM : We investigated the effect of prebiotics on the immunological response after influenza vaccination in enterally fed elderly individuals.
AIM : We reviewed the evidence regarding the pathogenesis of BPH / LUTS with particular attention to metabolic influence.
AIM : We sought to understand strategies employed by baby boomers to maintain well-being and facilitate transition to later life.
AIM : We studied the interplay between weight change and risk of hyperglycaemia in a prospective cohort of elderly women.
AIM : Whole-blood DNA methylation depends on the underlying leukocyte composition and confounding hereby is a major concern in epigenome-wide association studies.
AIM : β2-microglobulin ( β2M ) was proved to affect hippocampal functions in mice.
A increased collagen synthesis in dose dependant manner was also observed ( P < @number@ ) .
Airflow obstruction is , by contrast , more common in regions with a high prevalence of cigarette smoking.
Air pollutants damage the skin by inducing oxidative stress.
Air was analyzed for negative oxygen ions , SO2 , and inhalable particles , while drinking water and rice were analyzed for macro- and micro-elements.
Airway hyperresponsiveness ( AHR ) is a characteristic feature of asthma.
Airway hyperresponsiveness ( AHR ) occurs in both asthma and COPD.
Airway hyperresponsiveness has been shown to independently affect lung function growth in studies of adolescence.
Airway narrowing while SCUBA diving can cause dangerous complications like pulmonary barotrauma and arterial gas embolism.
A joinpoint regression model identified the annual percentage change ( APC ) in rates over the 50-year period.
A joint effort of all key stakeholders is needed to create a society in which older people can play an active role.
A Kaplan-Meier survival analysis was conducted to examine increases in care needs over time in months.
A KayPentax Digital Swallowing Workstation with an air-filled bulb array was placed on the tongue of each participant ( anterior to posterior ) .
AK can progress to nonmelanoma skin cancer ( NMSC ) and is a public health concern.
A key aspect of the regulatory niche is the vascular plexus , which modulates NSC behavior during tissue homeostasis and regeneration.
A key cause for a decrease in step length is the loss of muscle strength in the legs.
A key component of care is the recognition that chronologic age alone cannot guide the management of an older patient with breast cancer.
A key component to reducing health care costs and maintaining well-being in older persons is preserving physical function throughout the lifespan.
A key deficiency is the poor ability to mount robust antibody response.
A key determinant of geriatric frailty is sarcopenia , the age-associated loss of skeletal muscle mass and strength.
A key element in this structure-function relationship is the collagen fibril length.
A key element of the ACE Collaborative is the inclusion of patient advisors as members of the @number@ teams.
A key element of this transition involves placing greater emphasis on interest group activation and public policy deliberation.
A key feature during this process is the up-regulation of matrix metalloproteinases and cleavage of collagen.
A key feature of euL1db is its sample wise organization.
A key feature of this method is tuning-insensitivity , which greatly simplifies the computation by obviating cross validation for penalty parameter selection.
A key focus was to stimulate interactions between basic research and industry.
A key mechanism involved reduced proliferation , expansion , and differentiation of periosteal progenitor cell populations in aged mice.
A key mechanism underlying this development is the ability to detect cues.
A key mediator of the cellular response to damage and stress is the transcription factor NF-κB.
A key neuropathological event in AD is the accumulation of amyloid-β ( Aβ ) peptide.
A key outcome measure and treatment goal in aesthetic laser therapy is patient satisfaction.
A key partner of eukaryotic DNA helicases / translocases is the single-stranded DNA binding protein Replication Protein A ( RPA ) .
A key protein , sex peptide , is not conserved in vertebrates but plays a central role in mediating long-term effects on females after mating.
A key question concerns how adult stem cells use quiescence to establish or reinforce the property of self-renewal.
A key question posed by the authors is whether appearance and the work invested in it are legitimate considerations for dementia care policy and practice.
A key result is that this approach is enabling the organization to be more responsive in helping staff gain and maintain competencies.
A key tenet of our approach is to integrate EBIs with community best practices to the extent possible while building local capacity.
AKI can generally be prevented by proper maintenance of fluid balance.
A kidney biopsy revealed tubulointerstitial nephritis ( TIN ) with diffuse inflammatory cell infiltration.
AKI etiology , evaluated by peak serum creatinine ( SCr ) level and the requirement for dialysis , was not associated with nonrenal recovery.
AKI is a serious problem that is associated with mortality amongst hospitalized patients.
Akinetic crisis ( AC ) is akin to neuroleptic malignant syndrome ( NMS ) and is the most severe and possibly lethal complication of parkinsonism.
A kinetic mathematical model based on operational rate constants of DMT1 endocytosis and exocytosis is proposed.
Akin to oxygen , iron can be toxic and accelerate the aging process.
AKI patients were divided into transient or persistent AKI groups based on their renal function at @number@ days post-AKI.
AKI was defined according to KDIGO ( Kidney Disease : Improving Global Outcomes ) criteria.
AKI was defined according to the @number@ Kidney Disease : Improving Global Outcomes criteria.
Akp3 ( - / - ) mice display gut dysbiosis and are more prone to dextran sodium sulfate-induced colitis than wild-type mice.
AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy.
Akt1 ( + / - ) mice had a lower body weight than their littermates with less fat mass and normal glucose metabolism.
AKT3 was identified as a direct target of miR-22 , and restoration of AKT3 expression attenuated the effects of miR-22 in young EPCs.
Akt activation is mainly achieved by its binding to phosphatidylinositol ( @number@ ) -triphosphate.
Akt ( also known as protein kinase B ) is the main downstream target of phosphatidylinositol @number@'-kinase and has been implicated in epilepsy pathogenesis.
Akt and Erk @date@ proteins were detected by western blotting.
Akt and phospho-Akt levels were similar in both groups.
Akt and the transcription factor CCAAT enhancer-binding protein ( C / EBP ) mediated the genesis of these changes.
Akt inhibition either by chemical inhibitors or small interfering RNAs induced telomere dysfunction.
Akt phosphorylation increased in both groups but increased more in SNP ( P < @number@ ) .
Akt / Protein kinase B a signaling pathway as a main regulator of FOXO to perform a diverse function in organisms.
Akt-Ser473 phosphorylation , eNOS-Ser1177 phosphorylation , and PTEN protein levels in the cells were detected using Western blot.
AKT / β-catenin signaling played a role in the carcinoma cell proliferation and the treated xenograft tumors exhibited reduced levels of β-catenin and cyclin D1.
Ala1330Val and Val667Met genotypes were determined on genomic DNA by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) .
ALA-67 , ASN-74 and LYS-80 of binding region might be the key amino residues during the interaction.
Ala / Ala genotype of MnSOD polymorphism may have an effect on adverse features of PCa such as high stage disease.
A label-free protein profiling was then conducted to quantify proteins and compare profiles from mature and older women.
A lack of antioxidant supply to the core of ever-growing ocular lens could contribute to the cause of this condition.
A lack of driving confidence has been linked to self-limiting driving behaviours.
A lack of evidence exists on how to reduce fatigue and rigidity.
A lack of human connectedness can lead to loneliness , isolation , and deterioration of physical health.
A lack of information and embarrassment were identified as the main barriers to screening for this group.
A lack of robust RIBE was also demonstrated in hMSC co-cultured with irradiated cells ( p > 0.05 ) .
ALA cream of @percent@ was applied to PDT regions for 2h prior to light irradiation.
ALAD genotype was dichotomized as ALAD-2 carriers or not.
Alagebrium breaks advanced glycation end product crosslinks and improves LV stiffness in aged animals.
ALA is associated with beneficial changes in plasma lipids and the prevention of cardiovascular diseases.
A landmark period , yet its potential contribution to medicine at the time was limited and unknown.
Alanine aminotransferase ( ALT ) and aspartate aminotransferase ( AST ) levels were measured on fasting morning serum samples using the Kinetic method.
Alanine expansion mutations in poly ( A ) -binding protein nuclear @number@ ( PABPN1 ) cause muscle weakness in the late-onset disorder oculopharyngeal muscular dystrophy.
ALA-PDT or red light alone was applied to the forearm extensor.
A large amplitude oscillation was applied every @number@ min to simulate a deep breath.
A large array of gene involved in human longevity seems to be in relationship with insulin / IGF1 pathway.
A large array of observations shows that dysregulation of RAAS in the metabolic syndrome favors type @number@ diabetes.
A large body of clinical evidence has demonstrated the prevalence and risks of vitamin D deficiency in various chronic diseases.
A large body of current medical research aims at discovering how to increase longevity in human.
A large body of evidence also supports a strong association between DM , cardiovascular risk ( CV ) and testosterone deficiency syndrome.
A large body of evidence demonstrates that aging and MetS share several metabolic alterations.
A large body of evidence has accumulated demonstrating that the prevalence of asthma in the most advanced ages is similar to that in younger ages.
A large body of evidence illustrates the contribution of platelets to processes beyond their traditionally recognized role as mediators in thrombosis and hemostasis.
A large body of evidence indicates that JNK activity is critical for normal immune and inflammatory response.
A large body of evidence shows that induction of endogenous antioxidative proteins seems to be a reasonable strategy for delaying the progression of cell injury.
A large body of evidence suggests that inflammation is closely associated with AD pathogenesis and may be a promising target pathway for such interventions.
A large body of evidence suggests that the serotonin @number@ ( 5-HT6 ) receptors may be potential targets for cognitive improvement.
A large body of evidence supports a key role for telomere dysfunction in carcinogenesis due to the induction of chromosomal instability.
A large body of literature indicates that reproductive aging is associated with a decline in the somatotropic axis.
A large body of research has documented changes in self-esteem across adulthood and individual-difference correlates thereof.
A large change to a small number of individuals , or a small change to a large number of individuals ?
A large field of research seeks to explore and understand the factors that may cause different rates of age-related cognitive decline within the general population.
A large group of people imitate these experiments performed on animals , but the results of these experiments will not be known for several decades.
A large increase in properties going to auction was suggestive of such an association ( OR = @number@ @percent@ CI = @number@ @number@ ) .
A large initial reduction of E. coli O157 : H7 and Salmonella was observed , regardless of tissue type and chilling method.
A large inter-individual variability in SITT was observed , with times ranging from @number@ to @number@ min.
A large literature suggests that active social participation contributes to the well-being of older people.
A large middle-aged cohort is aging at a rate exceeding the progression of time , while 25- to 45-year-olds are relatively underrepresented.
A large number of blood-based markers have been proposed for early detection of colorectal cancer ( CRC ) .
A large number of enzymatic and chemical reactions involving phenolic compounds take place during winemaking and aging.
A large number of participants with a sufficient SMI value showed low muscle strength and / or a poor SPPBm score.
A large number of published trials also suggest that exercise is effective in decreasing fatigue.
A large number of studies on mitochondrial metabolism have been conducted in the last @number@ years , taking a broad range of approaches.
A large number of terpenoids exhibit potential geroprotector and anti-cancer properties.
A large part of the mammalian genome is transcribed into noncoding RNAs.
A large part of this decline is caused by the deterioration of tissue stem cell function.
A large part of understanding the mental health problem in this country starts at prisons.
A large proportion ( 23 / 85 ) of samples showed genetic variants of uncertain significance in addition to known mutations.
A large proportion are complications associated with shunt calcification.
A large proportion of EU and EEA residents are now susceptible to HAV infection.
A large proportion of these patients lost their independence after osteosynthesis of a hip fracture.
A large proportion of topical areas of interest in CER affects the older segment of the population.
A larger , longer trial could determine whether this treatment also reduces fracture risk.
A larger percentage of BCCP users were diagnosed at in situ or localized disease stage than overall.
A larger pooled cohort ( HEMATURIA ) of @number@ patients , including IgA nephropathy patients , was used for verification.
A larger randomized clinical trial is underway to provide further evidence of the effects of this decision aid intervention.
A larger randomized controlled trial is needed to demonstrate impact on important outcomes , such as surrogates ' well-being and decision quality.
A larger sample size , longer duration of follow-up and better methods of assessing anticholinergic-induced cognitive impairment are warranted.
A larger specifically designed randomised controlled trial could be merited.
A large sample of healthy adolescents ( n = @number@ ) was also used to compared hippocampal volumes between APOE groups.
A large-scale , well-designed RCT is needed to further address this issue.
A large web-based survey was undertaken over @number@ years to study the scale of this missed diagnosis.
Alarmingly , this study demonstrates that approximately @percent@ of Hong Kong workers do not save privately for their retirement.
ALA treatment enhanced CREBH and FGF21 mRNA expression and protein abundance in cultured hepatocytes.
Albumin extravasation was widespread in the ageing brain and enhanced in WML , suggesting dysfunction of the BBB may contribute to the pathogenesis of WML.
ALC1 / CHD1L is a member of the SNF2 superfamily of ATPases carrying a macrodomain that binds poly ( ADP-ribose ) .
ALC disproportionately impacts people with cognitive impairment , and insight into the needs and experiences of this specific sub population and their carers is lacking.
Alcohol abuse and dependence have proven to be complex genetic traits that are influenced by environmental factors.
Alcohol abuse can result in significant alterations to the structure of the brain and ultimately to behavioral dysfunctions.
Alcohol abuse leads to earlier onset of aging-related diseases , including cancer at multiple sites.
Alcohol aging significantly reduced the mechanical properties.
Alcohol , anabolic steroids and illicit substance use such as marihuana can impact on testosterone levels and non-prescribed drug use should be routinely discussed.
Alcohol consumption has emerged as a modifiable risk factor for cardiovascular diseases.
Alcohol consumption is a complex trait determined by both genetic and environmental factors , and is correlated with the risk of alcohol use disorders.
Alcohol consumption is associated with a broad array of physiologic and behavioral effects including changes in heart rate.
Alcohol consumption is strongly associated with pinguecula.
Alcohol-consumption patterns were developed based on the quantity and frequency of use in the @number@ months before the interview.
Alcohol consumption should be considered an age-varying risk factor for stroke.
Alcohol consumption was assessed at baseline , and drinking problems were indexed across @number@ years.
Alcohol consumption was assessed by a graduated frequency questionnaire , and problem drinking was defined as ≥2 positive responses on the CAGE questionnaire.
Alcohol consumption was assessed @number@ times in the @number@ years preceding the first cognitive assessment ( 1997-1999 ) .
Alcohol consumption was associated with higher concentrations of dehydroepiandrosterone sulfate , androstenedione and androstanediol glucuronide.
Alcohol consumption was categorized into four groups.
Alcohol consumption was defined as light , moderate and heavy drinking and used individually for each follow-up.
Alcohol consumption was measured at CCHS follow-ups in 1981-1983 , 1991-1994 and 2001-2003 , using a standard questionnaire.
Alcohol craving has many analogies in psychopathology with obsessive-compulsive behavior patterns.
Alcohol from spirits appears particularly important for the increased dementia risk.
Alcoholic liver disease ( ALD ) is a leading cause of morbidity and mortality worldwide.
Alcohol impairs the integrity of the BBB with oxidants and inflammatory mediators such as iNOS.
Alcohol intolerance is prevalent among East Asians , and we previously reported that coronary spasm could be induced by alcohol intake in CSA patients.
Alcoholism has always been a major public health concern in Taiwan , especially in the aboriginal communities.
Alcohol , opioids / heroin , and cocaine were more likely than other substances to be associated with treatment use.
Alcohol use disorder ( AUD ) and major depressive disorder ( MDD ) are often comorbid.
Alcohol use disorder ( AUD ) is a common , under-recognized , and under-treated health concern in older adults.
Alcohol use / nonuse groups were lifetime abstainers , ex-drinkers , bingers , and nonbingers.
Alcohol use reduction may be a useful population-wide intervention strategy.
Alcohol use trajectories were validated using phosphatidylethanol - a biomarker of alcohol consumption - measured between @number@ and @number@ among a subset of participants.
Alcohol use was predictive of depression , global psychological distress , and decreased quality of life.
Alcohol was often associated with social occasions and interactions both in private and in public spaces.
ALD and hearing aid usage were found to be associated with increasing age , hearing loss , and self-perceived hearing disability.
ALDH2 genotyping was performed by the direct application of the TaqMan polymerase chain reaction system on dried whole blood.
AL did not predict cognitive change from age @number@ to approximately age @number@
Aldosterone , used in studies of animal models of autoimmune hearing loss , slowed the progression of hearing loss.
ALD refers to a number of symptoms / deficits that contribute to liver injury.
A learning problem with older individuals may be due to a decrease in stability rather than a decrease in plasticity , at least in VPL.
A leave one out ( LOO ) evaluation study was performed with a dual QCT and HR-pQCT database of @number@ pairs of human femora.
A leisure education program was used to serve as the intervention.
Alerting and orienting attention scores were not affected by picture viewing.
A less pronounced risk increase ( 20-40 % ) was observed for persons with occasional symptoms.
A level of maximum control exceeds the subject's attentional capacity , which makes it impossible to perform both tasks simultaneously.
A level of significance of @percent@ was adopted for all analyses.
Alexithymia in FM patients follows a similar pattern as in healthy women ( although with significantly higher scores ) , increasing with age.
Alexithymia total score appeared to be uniquely predicted by Raven Matrices and Rey's Figure Recall.
ALG8-CDG is a severe disorder characterized by dysmorphic features , failure to thrive , protein-losing enteropathy , neurologic and ophthalmologic problems , and developmental delay.
Algorithmic diagnostic criteria used detailed neuropsychological data , medical history , longitudinal cognitive performance , and informant interview.
A life course approach to ageing relies on maintaining participation rates in national birth cohorts and other long-term longitudinal studies.
A lifelong course of vaccination may help to attenuate the effect of immunosenescence.
A lifelong high-fat diet also did not affect HSC function.
A life-span sample completed an incentive-compatible temporal discounting task involving both monetary gains and losses.
A lifestyle-related disease and osteoporosis are diseases to increase with aging and a lifestyle-related disease has an influence on the bone metabolism.
A light-scattering device was used to investigate the matrix organization of posterior scleral fibers around the ONH.
Alignment of the word to baseline was assessed using a multiple-choice checklist.
A limitation for this treatment is a low thyroid radioiodine uptake ( RAIU ) , often encountered in these patients.
A limitation was that BMI was mainly ascertained by self-report.
A limited number of controlled studies suggest that GH supplementation in older men increases lean mass by ∼2 kg with similar reductions in fat mass.
A limited number of pathways seem involved in these disorders , some of which are also implicated in cancer.
A limited number of studies explore the association between MCI and doing housework.
A limited number of studies have examined the co-occurrence of alcohol use and smoking and their mental health effects in middle and late life.
A limited number of tests were able to improve the CCR of the VSM when combined with the VSM for screening purposes.
A limited rate of recurrence requiring repeat surgery was observed only after subtotal parathyroidectomy.
A limiting factor in their application is the loss of MSC multi-potency as a result of high density sheet culture-induced senescence.
A linear decrease in serum albumin with increasing age was present for five of six animals.
A linear mixed effects model was used for association testing.
A linear mixed model was used to compare NET BPND between groups.
A linear mixed model was used to estimate the impact of age , sex , tumor type , and inflammation.
A linear model estimated the number of pamidronate cycles necessary to achieve mean MCW values equivalent to those of healthy children.
A linear regression analysis revealed that circulating MAIT cell levels declined annually by @percent@ among men and @percent@ among women , respectively.
A linear regression model was fit with age as dependent variable and ratio as predictor , allowing for interactions of specific gender or tooth type.
A linear regression model was used to calculate the rate of RSV-matAb decline.
A linear regression model was used to examine the relationship between nursing home organizational characteristics and NA benefits.
A line connecting Walker's point ( W ) and sphenoethmoidal ( SE ) created the x-axis.
A lipid-associated subpopulation of Aβ accounts for the high-affinity binding of Pittsburgh compound B ( PIB ) in Alzheimer's disease brain.
A lipid-like compound , named ( DGDG ) , was suggested to be responsible for the hemolytic activity in one of these fractions.
A lipidomic investigation through mass spectrometry highlights new insights on molecular mechanisms underlying cancer disease.
Alirocumab had no effects on FCRs or PRs of very low-density lipoproteins-apoB and very low-density lipoproteins triglycerides or on postprandial plasma triglycerides or apoB48 concentrations.
ALIs also may be applied to similar stress-related research areas among nonhuman primates.
ALIs estimate this wear-and-tear using a composite of biomarkers representing neuroendocrine , cardiovascular , metabolic , and immune systems.
A list of potentially anxiety-provoking situations was developed from a review of existing measures of social anxiety.
A list of requirements derived from the analysis is presented.
A literature review aimed to elucidate test parameters for in vitro aging of adhesive restorations was performed.
A literature review is provided here.
A literature review on visual assessment of MTA and hippocampal volumetry was conducted with other biomarkers addressed in parallel reviews.
A literature review was conducted regarding the career preferences of undergraduate nursing students from seven different countries.
A literature search on the determinants of color in human organs yielded scant information.
A literature search was conducted in PubMed and Web of Science.
A literature search was conducted to collect exergaming intervention studies that were either randomized controlled or uncontrolled studies.
A literature search was performed in major electronic databases from inception to @date@ .
ALK-1 rather than TGFβ is a promising therapeutic target.
Alkaline phosphatase activity and calcium and inorganic phosphate concentrations were used as indicators of calcification potential.
Alkaline phosphatase ( ALP ) activity was evaluated by ALP staining.
Alkaline phosphatase ( ALP ) staining was performed to assess ALP activity in C3H10T1 / 2 cells.
All adults aged @number@ years or older were invited to participate in both studies.
All adults should be vaccinated against pertussis with Tdap vaccine once.
All adults with such a fracture between @number@ and @number@ were included in the study.
All adverse drug reaction-related repeat admissions were found to be ' probable'.
All AEs were mild and anticipated , with no serious AEs.
All aged groups showed lower shear bond strengths than their matching nonaged group.
All age groups demonstrated increased MIC90 values for glycopeptide and tigecycline.
All age groups performed above chance with unmanipulated images.
All age groups revealed a comparable increase of probe errors with the former prime response in ignored repetition compared with control trials.
All ages and both genders are included.
All alcohol problems examined first occurred when subjects were in their late teens and early 20s.
All alcohol use categories were strongly associated with advanced hepatic fibrosis in HIV / HCV-coinfected patients.
All aMT6s levels were creatinine standardized ( [ aMT6s ] / [ creatinine ] ) , and the CCI was calculated.
All anaesthetic techniques , methods and agents can be applied , if tailored to the patient's physiologic and pathologic changes.
All analysed parameters negatively influenced the procedure , but only age and haematological toxicity during induction maintained their significance at multivariate analysis.
All analyses controlled for age and education.
All analyses included fine adjustment for cigarette smoking.
All analyses used Wald tests to compare sample means.
All analyses were adjusted by age , gender , education , and living arrangement.
All analyses were adjusted for age and gender.
All analyses were adjusted for age , gender and years of education.
All analyses were adjusted for relevant covariates.
All analyses were adjusted for sociodemographic factors and presence of comorbidities.
All analyses were adjusted for staff , resident , and living arrangement characteristics when needed.
All analyses were conducted in Comprehensive Meta-Analysis software using random-effects assumptions.
All analyses were intention-to-treat.
All analyses were made separately for men and women and for each anatomical site.
All analyses were performed using an intent-to-treat approach.
All analyses were performed using regression analysis.
All analyses were performed with RevMan ( version @date@ ) .
All analyses were stratified by age ( cutoff @number@ years of age ) and sex.
All analyses were stratified by race.
All analyses were stratified by race.
All analyzed features showed a significant statistical improvement @number@ months after the procedure.
All approaches consider disability a consequence rather than a cause of frailty.
All approaches seemed to decrease loneliness.
All appropriate articles were reviewed , and the evidence was compiled.
All array types experienced impedance declines , consistent with published literature showing chronic ( > 30 days ) declines in array impedance in vivo.
All articles were reviewed to identify those reporting variables of interest.
All assessed neuropsychiatric tests were comparable in both groups.
All assessments were independently conducted within @number@ hours of one another.
All assessments were made at baseline , after @number@ weeks of training and after @number@ and @number@ weeks of detraining.
All associations persisted when further adjusted for genetic and cerebrovascular risk factors.
All associations remained statistically significant after adjusting for age , sex , depressive symptoms , medical comorbidity , and body mass index.
All associations that reached the nominal significance level of P value < 0.05 were included.
All associations were adjusted for average blood pressure and cardiovascular risk factors.
All associations were independent of potential confounders , including APOEε4 status and nuclear genetic ancestry.
All associations were independent of season and sun exposure.
All associations were nonlinear , with the strongest relation at low PLP.
All associations were present during adaptation , but not during de-adaptation.
All athletes completed baseline medical and concussion questionnaires , and post-concussion data were collected for athletes with a documented concussion.
All athletes trained for approximately @number@ minutes , and they were consuming fluids ad libitum throughout their practice.
All atypical antipsychotics are associated with increased mortality in this patient population.
All authors declare to have no conflict of interest.
All available clinical trials , including animal and human studies , in English language that examined the protective effects of antioxidants against ARHL were reviewed.
All available EEGs were analyzed to compare evolution of spike-wave index ( SWI ) over the years.
All baseline performance-based measures were significantly associated with higher falls risk score at @number@ years.
All biomarkers except elastin showed a strong correlation with the cellular stiffness of HDFs.
All biomolecules suffer damages during cataract formation.
All blood samples were analyzed using ISAC microarray.
All bonding areas were first sandblasted with @number@ μm Al ( @number@ ) O ( @number@ ) ( @number@ MPa , @number@ s ) .
All but @number@ ( @percent@ ) were happy with the touch-up visit , @number@ to @number@ days after injection.
All but one of the quantitative studies reported that the reading interventions had a positive effect.
All but two collagen genes were up-regulated after @number@ hr of treatment.
All but two subjects reported improvement at the final visit.
All cancers are caused by somatic mutations ; however , understanding of the biological processes generating these mutations is limited.
All caregivers recognized some autonomic-related symptoms.
All caregivers were interviewed about their tasks and emotional impact using the short Zarit Burden Inventory.
All cases showed AGs to various degrees.
All cases showed parkinsonism ; voxel-based morphometry analysis showed greater precuneus atrophy in patients with delusions than those without delusions.
All cases were wild-type for BRAF , KRAS , PDGFRa and c-KIT ( data available for @number@ patients ) .
All cases with an AR mutation had gynecomastia , compared to @percent@ of those without an AR mutation.
All cases with growth remained > 20% after adjustment for skeletal growth.
All caspases were analyzed in terms of co-expression in comparison with @number@ genes involved in cholesterol homeostasis.
All-cause and cardiovascular deaths were assessed @number@ years later.
All-cause and cause-specific Cox proportional hazard models were used to test the association between semen quality and childhood mortality in family members.
All-cause and cause-specific mortality was followed for @number@ years.
All-cause dementia included AD and other types of possible or probable dementia.
All-cause hospitalization and hospitalizations specific to circulatory and digestive diseases were examined.
All-cause mortalities at 6-week , one- and two-year were determined using bivariable and multivariable Cox proportional hazard model.
All-cause mortality according to obesity and age was determined using Cox regression analysis , adjusted for related risk factors and previous cardiovascular events.
All-cause mortality by baseline plasma sex hormone levels was measured.
All-cause mortality , cardiac transplantation , and HF hospitalization were tracked for @number@ years.
All-cause mortality over six years was collected using data from the National Death Registry with adjudication by 4-monthly telephone interviews.
All-cause mortality , target vessel revascularization ( TVR ) , myocardial infarction ( MI ) , and the combination of these were primary study endpoints.
All-cause mortality was followed by means of an annual telephone or mailed survey.
All-cause mortality was similar across all mould-active agents.
All-cause MRR was stratified by sex , age and race / ethnicity.
All-ceramic Empress @number@ inlays were luted with four self-adhesive cements ( Clearfil SA , iCEM , Bifix SE , seT ) .
All-ceramic material is extremely sensitive to humidity and thermocycling.
All CGAs demonstrate moderate to high psychometric properties.
All children had visible joint fluid in at least one of the joints assessed.
All children used an exclusive 2-handed reach at a similar dimensionless ratio.
All children were assessed with the Cognitive Assessment System Expressive Attention subtest ( Big-Small Stroop ) , Fruit Stroop , and Boy-Girl Stroop.
All children were followed up for cancer from the age of @number@ until they were between @number@ and @number@ years.
All children were heavily infested.
All chronic conditions taken simultaneously accounted for about @percent@ of the ADL-related disability and almost @percent@ of the IADL-related disability.
All classes of obesity were significantly associated with higher general practitioner service use ( P < @number@ ) .
All classes of PA were associated with solid organ injury.
All clinical efficacy parameters showed statistically significant improvements over baseline at week @number@
All clinical patient records were retrospectively reviewed.
All CMs were found to inhibit overall collagen synthesis both in early passage and in senescent fibroblasts.
All cognitive domains had multiple neuropathology determinants that differed by domain.
All cognitive functions and gait speed were associated with the IGF-1 level ( p < @number@ ) .
All cognitive functions except vocabulary declined over the 10-year follow-up period.
All cognitive test scores were z-transformed for use in analyses.
All cognitive tests showed significant differences between the ' no depressive symptoms' , ' depressive symptoms' , and ' depression ' groups.
All comedians were given a subjective score from @number@ ( relatively funny ) to @number@ ( hilariously funny ) by the study investigators.
All components of innate and adaptive immunity are adversely affected to lesser or greater extent by ageing resulting in an overall decline of immunocompetence.
All composites showed initial residual contraction stresses , which were maintained when aged dry.
All compounds were tested over a 24-h period at @number@ and @number@ μM , in duplicate , with cytotoxicity measured using the MTT assay.
All conditions of continuous bimanual circle drawing were associated with age-equivalent temporal control.
All consecutive patients referred to a tertiary referral syncope unit over a decade were included.
All consenting residents aged ≥ @number@ years were interviewed for medical history and underwent neurological and cognitive examinations.
All considered predictors were statistically significantly associated with follow-up colonoscopy.
All correlation coefficients were , however , very low and the adjusted coefficient of determination also revealed the regression model to be very weak.
All cost data were extracted from national databases.
All CS-SeNPs could penetrate the tissues and perform their antioxidant effects , especially the CS ( l ) -SeNPs in mice models.
All CT group patients underwent abdominal CT whereas in the SIP group , imaging was based on the clinical assessment.
All currently known types - NF1 , NF2 and Schwannomatosis - predispose afflicted individuals to the development of glial cell-derived ( gliogenic ) tumors.
All data analyses were conducted in @number@
All data analyses were done by SPSS version @number@ software.
All data collection occurred between @date@ , and @date@ .
All data collection took place between @number@ and @number@
All data of NCSs were re-analyzed after adjustment for age , and obtained findings regarding effect of aging are also included.
All data on independent and dependent variables that were collected at each survey were simultaneously analyzed using a linear mixed-effects model.
All data were analysed using the ' framework ' approach.
All data were analyzed using RevMan @number@
All data were coded and emergent categories of causal beliefs identified.
All data were collected via the Internet , and an intention-to-treat analysis was carried out.
All differences remained after adjustment for body fat percentage ( BF% ) , aerobic fitness , age and puberty.
All discharge diagnoses were examined to determine if an infection occurred during hospitalization.
All discussions were audiorecorded and transcribed.
All disease association studies involving sSNPs are also reported.
All-disease mortality represents an alternative tool to study the impact of age.
All domains and subdomains were responsive to change based on patient-rated anchor questions.
All donors answered the Medical Outcomes Study short-form general health survey ; results were evaluated according to answers to @number@ questions totaling @number@ points.
All drugs acting on the autonomic nervous system can affect vision.
All drugs with well known anticholinergic activity , mild reported anticholinergic effects or in vitro anticholinergic activity were included in the study.
All DT conditions showed a benefit ( DTB ) for cognitive outcomes with trade-off cost to gait.
All ears had normal hearing and no history of ipsilateral facial palsy.
All echocardiographic indices were acquired , and their reference intervals were established.
All echographic parameters were significantly more altered in PE patients when compared with NP , in respect to any other form of hypertension.
All effect size estimates based on simulated data were compared to those computed based on the total scores in the observed data.
All elderly individuals will harbour many cells with the requisite mutations and most will develop occult neoplastic lesions.
All elderly were given a complete medical , anthropometric assessment , and psycho-social evaluation.
All elders had resided in their nursing communities for at least @number@ months before participation.
Allele and genotype distribution of this STR were studied in patients affected by schizophrenia ( SCZ ) and controls.
Allele and genotype frequencies were compared between cases and controls.
Allele and genotype frequencies were compared between the two groups using chi-square test and logistic regression models.
All elective and acute admissions to any speciality were eligible.
Allele frequencies in the nonsmokers were @number@ for the Arg / Pro allele and @number@ for the Pro / Pro allele in our study population.
Alleles of @number@ CODIS STR loci were determined using the AmpFLSTR Profiler Plus PCR Amplification Kit.
Allele-specific DNA methylation ( ASM ) and allele-specific gene expression ( ASE ) have long been studied in genomic imprinting and X chromosome inactivation.
Allelic and genotypic frequencies did not differ by sex in any of the study groups ( all p > @number@ ) .
Allelic and genotypic frequencies of the @number@ variants were compared between cases and control subjects independently and in combination.
Allelic differences in the Apolipoprotein E and ( APOE ) and Methylenetetrahydrofolate reductase ( MTHFR ) gene will be included for subgroup analysis.
All eligible participants were included , and general and medical information and information about their dental and prosthetic statuses were collected.
All endpoints within @number@ year after PCI were registered and validated.
All enrolled acute myocardial infarction ( AMI ) patients received percutaneous coronary intervention ( PCI ) therapy.
Allergic contact dermatitis is a T-cell-mediated inflammatory reaction and develops in predisposed individuals as a consequence of environmental exposure to allergens.
Allergic sensitization was defined by at least one positive skin prick test to @number@ aeroallergens.
Allergies and asthma are diseases that affect individuals of all ages , and their prevalence is comparable in all age groups.
Allergy to hyaluronidase should be included in the differential diagnosis when focal erythema and swelling occur after hyaluronidase injection.
All estrogen components of CEE are antioxidants , and some ring B unsaturated estrogens have several fold greater antioxidant activity than estrone and 17β-estradiol.
All ethical guidelines were followed.
All ethical precautions were observed.
Alleviating the burden of depression in the semi-homebound population may focus on early prevention that considers the diversity of this population.
All evidence-based stroke treatments including thrombolysis and hemicraniectomy could be performed.
All examined parameters showed significant correlation with age and gender.
All except one patient received antifungal prophylaxis ( in five cases triazoles ) .
All exercise modes resulted in significant increases of ROM but long-term improvements were only shown for NW and HBE.
All exons of EZR were sequenced after being amplified with polymerase chain reaction.
All exons of GJA3 , GJA8 , and LIM2 were sequenced after being amplified by polymerase chain reaction ( PCR ) .
All experimental results show that our proposed method can achieve better performance in terms of registration accuracy and robustness.
All eyes with absence of PVF were found to have established cisterns.
All facial changes are dependant on sex , ethnicity , and lifestyle.
All features aggravated with age.
All findings were primarily independent of age.
All flaps could successfully be salvaged.
All focus groups were recorded , transcribed , and coded to identify themes.
All food and drink intake recorded was analysed using WISP version @number@ and FV portions were manually counted using household measures.
All food was provided to participants for @number@ mo.
All forms of lower urinary tract symptoms can negatively impact physical and psychosocial function for affected patients and their caregivers and loved ones.
All forms of neurodegenerative diseases have a massive impact on the elderly.
All formulations were easily syringeable through @number@ gauge needle at cold temperature.
All four agents achieved crosslinking in micro-Raman after one minute application.
All four classic ALS patients were epigenetically older than their unaffected co-twins , suggesting accelerated aging in multiple tissues in this disease.
All four diffusivity indices had high heritability at the global level ( 72%-80% ) .
All four lifestyle factors combined account for @percent@ of incident locomotor disability and @percent@ of incident conditions combined.
All four performance measures decreased significantly ( p < 0.001 ) .
All frameworks were veneered with CAD / CAM-fabricated lithium disilicate ceramic ( IPS e.max CAD ; Ivoclar / Vivadent ) .
All genes were tested simultaneously as a gene set and each gene individually.
All German live births ( @number@ ) between @number@ and @number@ comprised the controls.
All gerontology courses hold a substantial focus on geropsychology ; however , only @number@ courses are available ( @number@ master , @number@ bachelor ) .
All-grade and severe AEs occurred in @number@ and @percent@ of patients , respectively ; @percent@ of patients required chemotherapy modification due to toxicities.
All groups , except for BARC , demonstrated significant differences dependent upon surface coating and solutions ( P < @number@ ) .
All groups exhibited higher DC at the end of @number@ minutes.
All groups improved performance to a similar amount.
All groups showed a reduction in serum glucose and uric acid levels.
All groups showed colour alterations above the clinically acceptable limit.
All groups showed restricted / clonal T-cell receptor responses ( 27%-70% ) .
All groups underwent full ophthalmologic examination ( fundus examination ) and ffERG.
All groups were statistically analyzed ( ANOVA , Tukey's , p < 0.05 ) .
All had an abbreviated mental test score≥ @date@ .
All had baseline normal cognition or MCI.
All had evidence of small increases in CSF intensity on the side or sides of the subsequent CSDH.
All had monomorphic histology with centroblastic / immunoblastic morphology ; @number@ cases were of GC type and @number@ of non-GC type.
All had participated in one to four 11-12 week lifestyle interventions ( residential weight loss programme , mixed activities ) .
All had ' passed ' the Mini-Mental State Examination ( MMSE ) .
All hand subjects and chest subjects showed improvement in all @number@ areas which were found to be statistically signi cant.
All have improved MGS , GCS , and ADL-BI.
All healthy children and adults tested could learn the new timing at the same rate and showed significant aftereffects.
All heme-dependent processes require the dynamic and rapid mobilization of heme from sites of synthesis or uptake to hemoproteins present in virtually every subcellular compartment.
All hemorrhagic strokes occurred in deep brain regions , and they were associated with MBs located in the deep brain region.
All HIV patients were non-hemophiliacs on HAART.
All HIV-positive adult patients that initiated ART between @number@ and @number@ were included.
All hormones were assayed using validated liquid chromatography and tandem mass spectrometry.
All Hosmer-Lemeshow simulations suggested that when parsed into random subgroups , the subgroup data matched that of the overall cohort.
All hospitalizations were examined from study entry until time of transplant , death , or @date@ .
All human conditions of IGF-1 deficiency consist in partially decreased IGF-1 levels since total absence of this hormone is hardly compatible with life.
All human populations display this particularity ; thus , it is difficult to empirically evaluate the conditions for its emergence.
All IDS-TILDA variables showing significant association ( P < @number@ ) with edentulism were entered into a regression model to identify predictors of edentulism.
All images were reviewed by a board-certified neuroradiologist , and MRI reports were searched for the terms cavernous malformation , cavernous angioma , and cavernoma.
All included studies were assessed for comprehensiveness of reporting , and a thematic synthesis of their results was performed.
All indexed hemodynamic measures were similar between sexes.
All indices suggested that the final model fit the data well.
All individual diseases including cancer were related to worse mental health as was having two or more conditions.
All individuals aged @number@ years and older were included ( n = @number@ @number@ @number@ both community-dwelling and institutionalized persons ) .
All individuals had best corrected visual acuity of 20 / 20 or better.
All individuals in the AD group had a Clinical Dementia Rating ( CDR ) ≤ @number@
All individuals walked on a dual belt instrumented treadmill while segment motions and ground reaction forces were recorded.
All individuals were receiving medical care.
All individuals were seeking specialized evaluation because of memory complaints.
All individual vessel flows and total cerebral blood flow ( TCBF ) declined with age , at @number@ mL / minute per year for TCBF.
All inflammation biomarkers were associated with FI-OutRef ( p < 0.001 ) .
All inhabitants over @number@ years of age ( @number@ individuals ) were invited.
All injections and observations of efficacy and safety were performed by the same two investigators.
All injections were carried out using a 25-gauge cannula after adding @number@ ml of @percent@ lidocaine to @number@ ml vials of the original product.
All instrumented TUG measures exhibited good to excellent ( ICCs > @number@ ) test-retest reliability in PwMS and in HC.
All interventions decreased faPWV ( P < @number@ ) similarly.
All interventions have limited capacity to resolve low back pain.
All intra-pair analyses were statistically non-significant , although greater in magnitude for monozygotic twins.
ALL is most common in the childhood and has high ( > 80% ) cure rate.
All isolates were inhibited by IB-367 at concentrations of 4-64 mg / l.
All isotypes are involved in inflammation , epidermal proliferation / differentiation and skin barrier function.
All items could be detected and quantified in our sample.
All items in both questionnaires were measured on a 5-point Likert scale.
All items were free from gender bias.
All items were understood by participants after another two rounds.
Allium atroviolaceum , a plant of the genus Allium has been used in folk medicine to protect against several diseases.
Allium cepa Linn is commonly used as supplementary folk remedy for cancer therapy.
All kidney biopsies studied were examined at Medical University of Warsaw in years 2009-14.
All known forms of Nrf1 protein , remained unchanged in the lungs of mice with age or in response to nPM.
All lesions , including @number@ cyst , @number@ sinus ( with internal opening ) and @number@ fistula , located in the left necks.
All life forms are under constant assault , resulting in an accumulation of damage within each individual , in both somatic and germline cells.
All life long , they are capable of accomplishing exceptional sporting performances.
All life story components were rated on emotion and age.
All living beings are programmed to death due to aging and age-related processes.
All living creatures have their inner clock that measures their daily ( circadian ) and their seasonal ( circannual ) time.
All lymphoid and myeloid blood cell lineages are continuously generated from hematopoietic stem cells present in human bone marrow.
All main caregivers filled out questionnaires evaluating autonomic symptoms.
All major specific causes of death contributed , and the highest excess is seen for alcohol-related deaths.
All Malaysian citizens or permanent residents with histologically confirmed diagnosis of colorectal cancer seen at UMMC from @date@ to @date@ were included in the study.
All married or widowed individuals aged @number@ and older who were alive and registered in Sweden on @date@ and still registered on @date@ .
All materials demonstrate chemical and structural stability under service simulated conditions.
All mature blood cells are generated from hematopoietic stem cells ( HSCs ) , which are the self-renewing units that sustain lifelong hematopoiesis.
All MCI subjects were educated and the majority were male.
All measured bone parameters were higher in the normal serum T group ( p < @number@ ) .
All measured values were analyzed by independent t-test.
All measurements had been made at the request of the general practitioner.
All measurements were indexed by dividing to body surface area ( BSA ) for standardization.
All measurements were obtained within @number@ weeks of surgery , irrespective of cycle day.
All measurements were performed by the same examiner at @number@ degrees centigrade and @number@ per cent humidity between 2 : 00 and @time@ .
All measurements were repeated three times with an interval of 3-5 weeks.
All measurements were taken at the level of the cricoid cartilage in a neutral head position in the spontaneously breathing patient during expiration.
All measurements were taken before and after interventions.
All measures distinguished the dementia and control groups and all markers associated with the cognitive test scores.
All measures drew on a 2-hour in-person interview.
All measures including neighborhood characteristics , height , and weight were self-reported.
All measures of CR were positively related to and predictive of FA.
All measures of HRV demonstrated between-group differences overnight on Day @number@ ( p < @number@ ) .
All measures were obtained blind to cognitive diagnosis.
All medians and @number@.5th-97.5th percentiles were plotted by cubic spline.
All medicinal and non- medicinal prescriptions were recorded at inclusion and will be followed up over @number@ years via an eCRF.
All men , 55- , 65- and 75-years old , living in Linkoping , Sweden ( n = 1885 ) received the questionnaire.
All men received once-daily tadalafil @number@ mg or placebo.
All mental , physical and sexual AMS subscales were significantly positively correlated with insulin levels and HOMA-IR.
All men were followed up for 36-42 months.
All methods employed were in-house.
All mice were of the BALB / c strain and were fed a basal rodent chow diet.
All mini-implants remained stable during treatment.
All MI sessions are audiotaped and coded to monitor treatment fidelity , which has been satisfactory thus far.
All misplacements were detected intraoperatively.
All models adjusted for sex , poor psychosocial health , education , marital status , and children in the household.
All models controlled for cigarettes smoked per day ( CPD ) and sociodemographic characteristics.
All models included covariates.
All models were adjusted for age , sex , and race.
All models were adjusted for baseline sex , education , wealth , cohabitation , smoking , and alcohol consumption.
All models were adjusted for sex , age , smoking , white blood cell proportions , array number , and position on array.
All models were stratified by urban-rural residence.
All models were well-calibrated.
All movements were detected and classified into three categories , separated by intervals of < 10 , 10-90 or > 90 s.
All MSA patients showed AI < 0.8.
All MS data have been deposited in the ProteomeXchange with identifier PXD001005 ( @url@
All mutations were de novo where parental DNA was available.
All neoplasms occurred after CRT , except for a single vestibular schwannoma within the cervical radiation field in a HL survivor.
All neuroimaging measures analyzed were significantly heritable ( ĥ ( @number@ ) = @number@.55-0.99 in unadjusted models ) .
All neurological on-site services and the telemedical network were successfully established within a short time.
All neurons are not created equal.
All neuropsychological and sensorimotor variables were also significantly associated with standard and dual task CSRT.
All newly admitted patients were recruited.
All new themes emerged from the qualitative interviews , some of which were also found in the literature.
All @number@ cohort studies indicated that the complication rates and clinical outcomes were similar between the inpatient and outpatient groups.
All @number@ entheses appeared normal on gray-scale imaging.
All @number@ exons of COQ2 in all the patients and exon @number@ in @number@ healthy controls ( HCs ) were directly sequenced.
All @number@ family caregivers receiving the Carer Support Needs Assessment Tool intervention provided feedback on their experiences via brief end-of-trial semi-structured telephone interviews.
All @number@ g / kg male rats died before the end of the study due to renal toxicity.
All @number@ g / kg males and females had splenic atrophy.
All @number@ groups exercised @number@ days·week⁻¹ for an average of @number@ to @number@ min·session⁻¹ over @number@ months.
All @number@ patients had common clinical features.
All @number@ patients had late-onset granuloma reactions , and the acute attacks were successfully treated with local injections of triamcinolone.
All @number@ patients reported skin and hair abnormalities within the first @number@ months of life.
All @number@ patients treated surgically , and eight of the @number@ patients treated conservatively showed improvement in paralysis.
All @number@ p.T96K patients also carried the TREM2 variant p.L211P , suggesting linkage disequilibrium.
All @number@ submissions were downloaded , coded and then entered into NVivo.
All @number@ words were judged as being acquired early ( mostly before the age of @number@ years ) .
All nutritional parameters are of pivotal importance.
All objective measures exhibited a significant mean-level decline across @number@ years , whereas most subjective indicators did not reveal significant mean-level changes.
All ocular parameters , telomere length and frailty were associated with chronological age , whereas CDKN2A expression was not.
All of our study subjects had at least two risk factors for TdP , with age and sex being the most common.
All of the BP ( brachial and ankle , systolic , mean , diastolic and pulse ) measurements were significantly associated with carotid augmentation index.
All of the cements became more opaque , while deltaCR ( difference in contrast ratio ) was significantly different ( p = @number@ ) .
All of the dementia dominant cases presented with this type of leukoencephalopathy on head magnetic resonance imaging.
All of the donors who had contact with their donor offspring reported positive experiences and the majority continued to have regular contact.
All of the estimated practice effects were positive , but they varied in magnitude across neurocognitive abilities and as a function of age.
All of the factors identified are relevant to both of these significant women's health issues , suggesting that they are strongly linked.
All of the factors mentioned above hinder progress in delivering individualized care to older patients with breast cancer.
All of the fitness variables declined over time but age acceleration did not correlate with subsequent change over @number@ years.
All of the major neurodegenerative disorders have relatively specific imaging findings that can be identified.
All of them are connected with decreased concentration of sex hormones.
All of them had completed secondary education.
All of them had nervous diseases.
All of them intensively interact with each other forming a united functional network of proteins.
All of them presented with severe asthma symptoms , and were found to have fungal sensitization by skin prick testing.
All of them underwent mini-mental state examination , apolipoprotein E ( APOE ) genotyping , and amyloid-PET.
All of them were always localized in the close vicinity of the blood vessels and expressed immunoreactivity to histamine H4 receptor antibody.
All of them were assessed with a neuropsychological battery.
All of them were located at approximately the most damaged spinal segment.
All of them were stained with tryptase and represent the MC-T phenotype.
All of them were treated by nasotracheal prolonged safe extubation.
All of the @number@ items were found to have significant item-to-total correlations.
All of the patients had received a neuropsychological assessment battery to assess cognitive function and self-designed questionnaires to collect relevant information.
All of the patients underwent a 13C urea breath test at least @number@ mo after the completion of eradication therapy.
All of the patients underwent spirometry for the determination of lung age.
All of the patients were assessed by the BACS as being cognitively impaired.
All of the patients were subjected to midface lifting with strengthening of the lateral canthus.
All of the respondents were fully mobile.
All of these disorders are now known to have an important immunological role in their pathogenic pathways.
All of these events resolved spontaneously.
All of these factors contribute to a high prevalence of coexistent CV and kidney disease , especially in the elderly.
All of these factors have led to the birth of geriatric nephrology.
All of these FC were significantly related to memory and global cognition in all participants.
All of these markers were significantly associated with lower scores on memory , processing speed , and executive function.
All of these measures showed improvement with increased number of averages.
All of these mediators were confirmed to be abundant in rat and human skin by mass spectrometry.
All of these models explicitly comprise stabilisation as an important process of successful , healthy ageing.
All of these modifications can explain the prevalence of erectile dysfunction with aging.
All of these observations indicate that astrocytes are capable of triggering the SASP and the astrocytes in aging brain display typical characteristics of cellular senescence.
All of these pathways converge to lead to axon dysfunction and symptoms of neuropathy.
All of these pathways have counterparts in humans.
All of these perspectives combined highlight the founding principles of the clinical application of corneal stromal replacement , a concept that has now become reality.
All of these reactions lead to a series of functional changes that participate in neurological and vascular complications of diabetes , metabolic syndrome.
All of these representations are with respect to the body.
All of these subtypes are zoonotic , and may pose a potential threat to human health.
All of these tissue-related and allele-related heteroplasmies show a significant age-related accumulation , suggesting positive selection for specific alleles at specific positions in specific tissues.
All of the subjects completed the study , and no severe adverse events developed during the study period.
All of the subjects were obtained from NHIRD with index dates from @date@ to @date@ .
All of those characteristics seem to contribute to decreased proliferation potential of those cells.
All of us are familiar with the negative impact of interference on achieving our task goals.
Allogeneic MSCs have also been tested in initial clinical studies in cardiology patients.
Allogeneic MSCs offer several advantages over autologous BMCs ; however , immune rejection of allogeneic cells remains a key issue.
Allogeneic MSCs , unlike syngeneic ones , were eliminated from rat hearts by @number@ weeks , with a loss of functional benefit.
Allografts are available in adequate quantity but concerns still remain about the risk of infections , moreover they do not have osteogenetic properties.
All older adults exhibit some degree of swallowing difficulty , also known as senescent swallowing.
All older patients with hip fracture , irrespective of their admission frailty-robustness profile , should receive geriatric evaluation and intervention.
Allometric relationship was explored to assess the impact of REE on the CL of therapeutic proteins in pediatric subjects.
Allometric scaling is a method which can be used for PK extrapolation from adults to children.
Allopathic medicines have been playing a key role in the treatment of several diseases.
Allopregnanolone is produced in the brain at stress.
Allopurinol inhibition of xanthine oxido-reductase was shown to be efficient in some cases of cardiovascular diseases.
Allopurinol is the most widely used urate-lowering therapy ; however , many gout patients who are prescribed allopurinol do not have urate levels optimally controlled.
Allopurinol up-titration was effective in achieving urate target levels and was generally well tolerated by patients.
Allostatic load ( AL ) has been proposed as a general framework for understanding the cumulative effects of life stress on individuals.
Allostatic load also increased with age , but the association between negative emotional response and allostatic load remained stable over time.
Allostatic load represents the strain that chronic stress exerts on interconnected biological systems.
Allostatic load was calculated using cardiovascular , metabolic and immune function biomarkers at three clinical follow-up examinations.
Allostatic load was strongly inversely associated with performance in both episodic memory and executive function.
All other CGAs cover seven domains or fewer.
All other complications had an incidence of less than @percent@.
All other groups showed no statistical differences.
All other hormones from the adrenal , somatotrophic and gonadal were not significantly associated with cognition.
All other leaks were equally prevalent across genotypes independent of age.
All other nurse coordinator intra-role as well as inter-role correlations were also positively correlated , although not statistically significant.
All other parameters under investigation were not affected by leucine supplementation in a fashion significantly different from controls.
All other patients were controls.
All other solutes showed no difference.
Allotransplantation of MSCs may alleviate some of these obstacles , although the long-term stability of MSCs and efficacy in pulp-dentin regeneration demand further investigation.
All our findings suggested that up-regulated SSTR1 contributed to neuronal apoptosis after ICH , which was accompanied with reduced expression of bcl-2.
All outcomes were considered using a narrative approach.
All outcome variables were modelled as continuous and dichotomous.
All over Europe , the provision of healthcare services is widely considered a primary duty of the government.
Allowing FPA and Prescriptive Authority ( PA ) enables NPs to become more efficient and effective patient care team members.
Allowing nurse practitioners and other providers to practice to the full extent of their licenses will result in improved care coordination.
Allowing transient impact force spikes may be necessary to initiate a bone response in elderly men as the intervention was ineffective.
All paints suffered color alteration.
All parameters had returned to baseline values at the re-mobilisation phase of the study.
All parameters had returned to baseline values at the re-mobilisation phase of the study.
All parameters were assessed before and after the treatment period of @number@ weeks.
All parameters were evaluated at baseline and year @number@
All parameters were measured and calculated automatically using the eRAD PACS Viewer ( eRAD Inc. , version @number@ ) .
All parameters were measured before the beginning of treatment , and @number@ and @number@ days later.
All parameters were measured twice ( test-retest ) under the same conditions within a week's period.
All parameters were significantly larger in the male subgroups with the exception of gnathion-gonion distance and gonial angle.
All participants above the age of @number@ years reported sleeping at noon.
All participants agreed to undergo annual clinical evaluations and to donate their brains after death.
All participants answered a diet history and were tested with pure-tone audiometry.
All participants benefited from small ITDs between the target and masker sentence with regard to the unmasking of IM.
All participants completed all @number@ sleep schedules.
All participants completed a self-report questionnaire in their preferred language.
All participants completed established tests of executive function including the task switching paradigm , n-back and running memory span at baseline and follow-up.
All participants completed self-report questionnaires tapping personal and medical data , QoL and functional limitations.
All participants completed the Adolescent / Adult Sensory Profile and the Activity Card Sort.
All participants completed the Dermatology Life Quality Index and the Work Productivity and Activity Impairment-Specific Health Problem questionnaires.
All participants completed the Korean Mini-Mental State Examination , which was validated in the Korean language , to assess cognitive function.
All participants completed the Lille apathy rating scale ( LARS ) and the Iowa gambling task ( IGT ) .
All participants completed the Pittsburgh Sleep Quality Index , and responses of CIND and non-CIND individuals were compared.
All participants completed two questionnaires , FAQ1 ( for knowledge ) and ASD ( for attitudes ) in their own languages.
All participants considered physical activity important to health preservation.
All participants experienced HFS challenges such as limited mobility and financial constraints.
All participants from the studies lived in the community or institutions and were aged @number@ or older.
All participants had information on smoking history collected before age @number@ years and at least @number@ years of follow-up after age @number@
All participants had medically intractable seizures associated with unilateral HS and an onset of epilepsy in childhood , with an average onset at @number@ years.
All participants had reported long-term pain and were interviewed about this.
All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software.
All participants live alone or with family.
All participants maintained preferred gait symmetry and lag times independent of cue symmetry.
All participants met the inclusion criteria for depression , which were defined by The Geriatric Depression Scale ( GDS-15 ) .
All participants of @number@ focus groups would be willing to indicate at least @number@ condition in which they would not want to be fed.
All participants performed a semantic and a perceptual incidental encoding task.
All participants performed single-task blocks and mixed-task blocks ( involving unpredictable switching between @number@ tasks ) in silent and labeling conditions.
All participants performed the exercises autonomously at home.
All participants performed the maximal explosive grip test three times.
All participants performed two maximal grip attempts.
All participants provided demographic information and hearing aid owners were asked about their aid use.
All participants provided saliva samples for genetic analysis.
All participants read , understood , and signed informed consent forms under data collection procedures by trained individuals.
All participants received an accumulated @number@ min of NMES ( @number@ Hz , @number@ ms on / 800 ms off ) of the median nerve.
All participants received calcium ( @number@ mg ) and vitamin D3 ( @number@ IU ) daily.
All participants received history taking , physical examinations , and laboratory tests.
All participants received @number@ min group training sessions , once a week for @number@ weeks.
All participants shared feelings of being treated poorly by medical professionals and lacking information about renal disease and treatment options.
All participants showed a decrease in performance self-esteem levels following the MIST.
All participants signed an informed consent form.
All participants signed a written consent form , and the study has been approved by the Regional Committee for Medical Research Ethics , Norway.
All participants significantly preferred the eBook ( p < 0.01 , @percent@ CI ) .
All participants spoke English as a first language and had normal hearing below @number@ kHz.
All participants took part in two 2-h testing and to two 2-h training sessions.
All participants underwent a comprehensive eye examination and a standardized interview.
All participants underwent an electrographic study in the classical manner described in the literature.
All participants underwent an established 2-back working task in a crossover design of @number@ mg caffeine versus placebo.
All participants underwent a thorough clinical examination to ascertain all-cause dementia and AD.
All participants underwent baseline polysomnographic recording and a comprehensive neuropsychological assessment.
All participants underwent collection of blood samples , neuropsychological assessment , and 3-T MRI.
All participants underwent detailed echocardiography , including LV ejection fraction , average septal-lateral E / e' , and LV mass index ( LVMI ) .
All participants underwent locomotion analysis using a Three-dimensional motion analysis system and 12-channel dynamic electromyography.
All participants underwent neuropsychological testing , structural and resting-state functional MRI.
All participants underwent structural neuroimaging to assess global and regional brain morphology and completed neuropsychological tests sensitive to early changes in cognitive function.
All participants underwent subsequently a full clinical examination by a physician exploring the same areas ( rater-VDSP ) .
All participants were administered an extensive neuropsychological battery composed of measures of attention , executive function , memory , and visuospatial function.
All participants were aged at least @number@ years of age with no acute illness , and HIV-infected individuals were on stable ART.
All participants were also given varying combinations of vitamins C , E , beta carotene , and zinc.
All participants were asked for a Gout Assessment Questionnaire under the guidelines of the American College of Rheumatology.
All participants were asked to comment on the straws used.
All participants were asked to fill the Life Satisfaction Questionnaire ( Fragebogen zur Lebenszufriedenheit - FLZ ) .
All participants were asked to fill the NEO-FFI.
All participants were assessed to have healthy vision and hearing for their age.
All participants were assessed with 20-item Toronto Alexithymia Scale.
All participants were compared on the following variables : total errors , proportion of errors detected , and proportion of errors corrected.
All participants were diagnosed as cognitively normal at every study visit , which ranged from three to nine approximately annual evaluations.
All participants were diagnosed with IH between @date@ and @date@ , had normal heart function , and had not been previously treated for IH.
All participants were evaluated by using a semistructured questionnaire and the Golombok Rust Inventory of Sexual Satisfaction questionnaire.
All participants were examined after @number@ month and @number@ months , then annually for @number@ years.
All participants were followed for @number@ years ; survival status and admission into institutions were tracked continuously through administrative registers from @number@ to @number@
All participants were followed up for @number@ months.
All participants were free of identifiable ocular disease and had normal or corrected-to-normal visual acuity.
All participants were French descendants from Quebec City , Canada.
All participants were from Dujiangyan , @number@ km from the epicenter of the @date@ earthquake , in China.
All participants were functionally normal with Mini-Mental State Examination scores ranging between @number@ and @number@
All participants were instructed to attempt to recover balance by taking a rapid single step.
All participants were interviewed to obtain demographic , physical , and health data.
All participants were non-Hispanic Whites.
All participants were of the same Caucasian ( Spanish ) descent.
All participants were reassessed for cosmetic changes at @number@ @number@ and @number@ weeks.
All participants were referred to a memory clinic.
All participants were reliably light-adapted by the equilibrium bleach.
All participants were scanned with magnetic resonance imaging.
All participants were screened for ( mild ) cognitive impairment.
All participants who were reported to experience a hallucination had poor vision.
All participants will be assessed at baseline , @number@ and @number@ months post-randomisation.
All patient rooms in the new unit are single occupancy with en-suite facilities.
All patients affected by Bell's palsy within the health district and four controls for each case were included.
All patients also underwent DSA before or after the MR examination.
All patients began a 5-week cardiac rehabilitation supervised training.
All patients benefited from a comprehensive geriatric assessment.
All patients completed the study and no complications were noted.
All patients could continue cetuximab treatment without dose reduction.
All patients demonstrated a residual effect @number@ months after the treatment.
All patients developed mild bruising and swelling but no discoloration or lumpiness.
All patients experienced adverse events , the majority of which were deemed treatment related.
All patients had a 4-week washout.
All patients had amnesia symptoms , which were not statistically significant.
All patients had a pathological diagnosis of AD , but only four had pure AD.
All patients had at least @number@ months of post-treatment follow-up and consolidation therapy duration.
All patients had confirmed aspirate and arthroscopic / arthrotomy infection.
All patients had earlier history of diabetes and vitrectomy 23G for diabetic complications.
All patients had excellent cosmetic results.
All patients had intima-media thickness ( IMT ) measured.
All patients had positive PIB-PET scans.
All patients had reduced uptake corresponding to RT fields.
All patients had serial clinical exams and evaluations with an average follow-up of @number@ months ( range , 6-50 months ) .
All patients had unilateral conductive hearing loss.
All patients had upper eyelid dermatochalasis with visual field limitation , and the functions of their levator palpabrae were all normal.
All patients had volumetric MRI , RESULTS : As expected , the MENO group was older than the PERI and CNT groups.
All patients have been evaluated at @number@ mo with clinical examination , anorectal manometry and endoanal ultrasonography.
All patients have been satisfied with the results.
All patients healed uneventfully without any major postoperative problems.
All patients increased their water intake to @number@ L / d and alimentary fiber to 20-25 g / d.
All patients indicated that they were usually aware when hypoglycaemia occurs but the symptoms reported were mostly non specific.
All patients met the established criteria for delivery of GDFT for greater than @percent@ of case time.
All patients must have carefully taken preoperative and postoperative pictures.
All patients @number@ years and older ( n = @number@ ) were included.
All patients presented were aged ≥70 years with a hip fracture , who underwent surgery with osteosynthesis or arthroplasty.
All patients presented with abdominal pain , more often located in the epigastrium ( n = @number@ ) .
All patients presented with headache and papilledema.
All patients previously tested negative for pathogenic BRCA1 and BRCA2 mutations.
All patients received a diet plan on discharge.
All patients received a standardized questionnaire , physical and biochemical examinations , echocardiography , ankle-brachial blood pressure index and orthostatic blood pressure measurement.
All patients received interventions for a period of ten weeks.
All patients received postoperative multimodal analgesia.
All patients received primary PCI.
All patients received regular pharmacy counselling.
All patients received supportive care measurements and atropinization.
All patients received usual care treatment.
All patients receiving FMT from their respective donors had resolution of RCDI symptoms and had a negative C. difficile toxin test 4-12 weeks after FMT.
All patients reported satisfaction with the aesthetic outcome.
All patients reported to be satisfied with the obtained results.
All patients required long-term care and were examined for the presence of a sucking reflex , snout reflex and phasic bite reflex for baseline measures.
All patients responded to the questionnaires : International prostatic symptom score ( IPSS ) , Overactive Bladder Symptom score ( OABSS ) .
All patients responded well to antibiotic therapy.
All patients seeking skin rejuvenation can benefit from this low-risk intervention.
All patients showed significant TDP-43 linked degeneration of LMNs , and five cases showed a lesser degree of motor cortex degeneration.
All patients significantly improved their audiological and speech understanding performances.
All patients underwent a 6-minute walk test and spiroergometry testing.
All patients underwent a complete ophthalmologic evaluation at baseline and at each follow-up visit ( months @number@ @number@ and @number@ ) .
All patients underwent a Comprehensive Geriatric Assessment ( CGA ) , from which a multidimensional prognostic index ( MPI ) score was calculated.
All patients underwent CAC and BMD assessment.
All patients underwent clinical-neurological examination , laboratory tests , high resolution B-mode ultrasound examination , MRI.
All patients underwent comprehensive geriatric assessment.
All patients underwent echocardiography to detect the occurrence of AVC.
All patients underwent full ocular examination and Pentacam ( Oculus Optikgeräte GmbH ) measurement.
All patients underwent multidimensional geriatric assessment.
All patients underwent peritoneal washing , simple hysterectomy with bilateral salpingo-oophorectomy and nodal staging including SLN mapping , or LD.
All patients underwent submaximal exercise test.
All patients were assessed and classified according to the hearing preservation classification.
All patients were categorized into the home care group and institutional care group based on their living arrangement before GEMU admissions.
All patients were divided into three age subgroups.
All patients were evaluated using SHIM and IPSS questionnaires.
All patients were female , and @percent@ had a history of previous fracture.
All patients were female , with an average age of @number@
All patients were followed up 6-12 months.
All patients were followed up for two years to help develop a protocol for injection technique.
All patients were Global initiative for chronic Obstructive Lung Disease ( GOLD ) stages I-IV and were aged @number@.1±9.1 years.
All patients were initially treated with gefitinib ( @number@ mg / day ) at seven institutions.
All patients were men , and the average age of death was @number@ years.
All patients were offered to receive their medication in MCAs prepared in the pharmacy.
All patients were operated on by the senior surgeon ( M.P.C. ) .
All patients were photographed from a frontal view , with measurements taken from these photographs.
All patients were provided home-based PAC , institution-based PAC or conventional home care ( CHC ) based on their capacity of family care resources.
All patients were reassessed @number@ days later.
All patients were recruited from neurology clinics.
All patients were satisfied to extremely satisfied with the treatments and all reported moderate to excellent visible results.
All patients were satisfied with the final outcome of their ACLR surgery.
All patients were satisfied with the results.
All patients were scheduled for general surgical procedures with general anesthesia.
All patients were still alive to follow up for 11∼18 years.
All patients were subjected to detailed echocardiography , vascular ultrasound , and high-resolution echotracking ( eTracking ) of carotid arteries.
All patients were systemically well at the time of presentation , with no other foci of infection detected after septic screening.
All patients were treated by corticosteroids and showed significant clinical and radiological improvement.
All patients were untreated and had a severe degree of disease.
All patients who developed granulomas had had a previous lower blepharoplasty ( P = @number@ ) .
All patients who received vertebral augmentation for vertebral compression fractures were evaluated.
All patients with AAA studied by coronary angiography showed significant coronary lesions.
All patients with AKI were followed up for @number@ days after AKI diagnosis or until death.
All patients with a known HIV / HCV coinfection on @date@ , were included.
All patients with B-K fused PLGA are still alive.
All patients with carotid stenosis should receive aggressive medical therapy.
All patients with dizziness and falls should have a vestibular assessment ( especially peripheral ) to improve quality of life and reduce falls.
All patients with elevated parameters of liver function tests ( LFTs ) were fully investigated , managed and followed up in accordance with AGA guidelines.
All patients with GBM during 1985-1998 in the NCDB were examined for comparison.
All patients with incidental VTE regardless the location received half to full therapeutic doses of low-molecular-weight heparin for a minimum of three months.
All patients with pain / functional pathology had immediate initial improvement but @percent@ had recurrence of pain at @number@ months.
All patients with the age @number@ or higher undergoing microvascular operations were reviewed.
All PCBs decreased cell proliferation from day @number@ only PCB @number@ produced a small increase of cells in G0 / G1 of the cell cycle.
All @percent@ confidence intervals included the null value.
All PHP-Ia patients showed resistance toward TSH , in addition to PTH.
All physical therapists considered the items relevant , but the written instructions could be improved.
All physicians must evaluate kidney function using estimated glomerular filtration rate calculated by the new Japanese equation in patients with HF.
All physicians were exposed to validated assessment scales for the upper face and the lower face for skin aging analysis.
All pleural effusions were loculated , @percent@ macroscopically purulent , @percent@ had a positive organism in Gram stain , and @percent@ were culture positive.
All polymorphisms were genotyped by PCR and / or PCR-RFLP.
All possible interactions between conditions and treatments were extracted from each case's record into a multimorbidity interaction matrix.
All potential factors were allocated into five groups including demography , chronic diseases , geriatric conditions , lifestyle and physical assessments.
All predictions were confirmed : Sentences with short words and syntactically more difficult sentences elicited more irregular scanpaths.
All predictors in the four considered regression models were statistically significant.
All predictor variables , with the exception of TMT-A errors , were significantly correlated with driving outcome.
All presented datasets can be used for longitudinal analyses and are available to the scientific community.
All prevalences significantly increased with aging.
All primary and secondary efficacy endpoints were greater in Study @number@
All procedures were performed laparoscopically.
All procedures were performed successfully without any complications.
All protocols ended with muscle failure.
All providers were asked about order set ' use ' and ' usefulness'.
All questionnaire respondents were invited to attend an assessment centre for a comprehensive physical assessment.
All quiescent SK-UT-1 cells died within @number@ days after treatment with a single dose of C21.
All randomized controlled trials of EXD for osteoporosis were included.
All randomized , controlled trials testing the treatment effect of vitamin E supplementation in adults for at least one year were sought.
All rare variants were heterozygous.
All rare variation was detected in the heterozygous state and no compound heterozygotes were observed.
All RBCs were stored at 4°C for @number@ days with assay of in vitro variables on days + 1 , @number@ @number@ @number@ and @number@
All received MBA degrees between the years of @number@ and @number@
All regions remained significant after correction for multiple comparisons via permutation testing.
All regions showed strong reduction of gray matter volume with age.
All reparative mechanisms in acute and chronic cochlear damage attempt to reduce oxidative stress and to balance inner-ear homeostasis.
All replicas were submitted to accelerated aging for @number@ hours.
All residents ( age ≥6 years , no upper age limit ) are eligible.
All residents in an area of Nakajima , Japan , were considered as potential candidates ( n = @number@ ) .
All respondents expressed their agreement or disagreement with the statements presented in the questionnaire regarding positive or negative attitudes to ageing.
All respondents were interviewed using the World Mental Health version of the Composite International Diagnostic Interview.
All restorations were adhesively bonded using a resin cement ( Variolink Esthetic ) .
All results are based on published data.
All results are statistically significant ( P < .05 ) .
All results controlled for data quality metrics , including motion.
All results were corrected to reduce errors arising from the increase in crystalline lens thickness with accommodation.
All results were statistically analyzed in a linear regression model with SPSS software ( version @number@ SPSS , Chicago , IL ) .
All routinely utilized sedatives and anesthetics have been found neurotoxic in a wide variety of animal species , including non-human primates.
All samples analyzed after storage for 1h or @number@ day in the aging media showed two Tg values.
All samples analyzed after storage for @number@ or @number@ days in the ageing media showed a unique Tg value.
All samples were genotyped in duplicate using Real-Time PCR.
All samples were infected with an artificially formed biofilm made of Enterococcus faecalis , Streptococcus salivarius , Porphyromonas gingivalis and Prevotella intermedia bacteria.
All samples were negative for CMV.
All samples with achieved PCR-RFLP genotyping showed a common genetic character of type Chinese @number@ ( ToxoDB # 9 ) .
All scales categorized @percent@ of participants as frail.
All scans were performed with a Philips CX / Q. The patients ' ages were between @number@ days and @number@ years.
Allscripts Home Care and Lifestream software was used to query data from patient records.
All sealing materials blocked more fluorescence when applied to a depth of @number@ mm.
All searches , data extraction and evaluations were performed independently and in duplicate.
All searches were carried out on @date@ and were not limited by date.
All secondary rhytidectomy patients expressed satisfaction with their overall aesthetic result.
All semen samples were assessed for volume , concentration , motility and morphology.
All significant correlations were homogeneous across studies.
All significant variables at P < @number@ upon univariate analysis were entered into a multivariate logistic regression model to identify risk factors for DGF.
All SK and four of five EN displayed reduced common deletion levels compared with adjacent normal skin.
All skin changes recovered after unloading.
All skulls showed asymmetry in all measures , except @number@ of them that showed symmetry in VD and perimeter.
All SMART-MH activities were offered in Spanish , Russian , Mandarin / Cantonese , and English.
All specialities should be informed for diabetic bladder disfunction and necesssity for recognition and treatment.
All specimens of the aging groups debonded during thermocycling and were considered to present zero bond strength for the statistical analyses.
All specimens showed increase in color changes toward yellowness Δb after a period of @number@ @number@ @number@ and @number@ days.
All specimens were aged by Thermocycling and water bath.
All specimens were aged in distilled water for @number@ hours at @number@ degrees C and a shear bond strength test was performed.
All specimens were cemented under a load of @number@ g.
All specimens were divided into eight test groups , and each test group was divided into two subgroups.
All specimens were insensitive to artificial aging.
All specimens were submitted to artificial aging ( @number@ mechanical cycles , @number@ N load , @number@.7-mm sliding movement , @number@ thermocycles ) .
All spoke standard Portuguese and none had a history of vocal and laryngeal alterations or respiratory diseases.
All sports declined with increasing age , with rowing showing the least deterioration.
All statistical analyses were performed by SAS @number@ ( Statistical Analysis Software release @number@ SAS Institute Inc. , Cary , NC , USA ) .
All statistical analyses were performed with @percent@ confidence intervals with significance determined at P < 0.05.
All statistical analyses were stratified by gender.
All statistical tests were two-sided.
All statistical tests were two-sided.
All statistical tests were two-sided.
All statistical tests were two-sided.
All statistical tests were two-sided.
All statistical tests were two-sided.
All statistical tests were two-sided.
All statistics were performed by SPSS13.0.
All steps of image acquisition from device selection , scan preparations and parameters to image post-processing influence the magnitude of metal artifacts.
All steroidogenic components were present , although only keratinocytes expressed the organic anion organic anion transporter protein ( OATP ) 2B1 transporter.
All stimuli were presented with steeper ( @number@ ms ) and less steep ( @number@ ms ) envelope rise and fall times.
All studies discussed long-term survival in the PEG versus non-PEG populations.
All studies evaluating outcomes following outpatient THA , TKA , or UKA were included.
All studies examined at least two groups.
All studies incorporated extrinsic measures of muscle fatigue , such as declines in maximal voluntary contraction or available active range of motion.
All studies measured the effects of tDCS via MEP TMS paradigm.
All studies provided ≥2 hours of exercise per week , and @number@ study provided > 50 hours of exercise during the study period.
All studies were assessed to be at risk of bias.
All studies were categorized into @number@ subgroups of intervention approaches ( cognitive restructuring , education , and problem-solving ) , and subgroup analysis was performed.
All studies were community or clinical based.
All studies were complete and published in peer-reviewed journals.
All studies were in residential care ; none was population-based.
All studies were longitudinal trials , with MCI sample , aged > 60 years , community-dwelling , and having cognitive functions as dependent variable.
All studies were of moderate to good quality , except for one study of poor quality.
All study designs were considered , though reviews , editorials , letters to the editor and opinion pieces were excluded.
All study participants completed two dietary recalls and a dietary supplement ( DS ) questionnaire in Wave @number@ ( n = @number@ ) .
All study participants did not experience any difficulties while operating the tested device for independent wrinkle reduction treatments.
All study participants were subjected to the University of Pennsylvania Smell Identification Test ( UPSIT ) , blood β-endorphin ( BE ) and CGRP measurement.
All study subjects were between the ages of @number@ and @number@
All subcortical and ventricular regions except caudate nucleus and the fourth ventricle changed significantly over @number@ year.
All subcortical gray-matter regions exhibited elevated PiB uptake , but despite this , only the hippocampus showed reduced glucose metabolism.
All subject data were downloaded from the Alzheimer Disease Neuroimaging Initiative.
All subjects adjusted the intensity of the surround until the target was no longer visible.
All subjects also were given supportive skincare , consisting of a cleanser , moisturizer , and sunscreen.
All subjects completed a structured questionnaire and had their bone mineral density ( BMD ) measured using DXA.
All subjects completed @number@ golf swings using their personal driver.
All subjects completed SF-36 health and Androgen Deficiency of the Aging Male questionnaires.
All subjects completed the Berlin questionnaire and underwent at-home respiratory recording.
All subjects displayed variable improvements in tactile sensitivity and eight subjects developed lower limbs motor functional gains , principally in the hip flexors.
All subjects had a reliable informant ( primary caregiver ) and informed consent was obtained from patients or their primary caregiver.
All subjects participated in a physical activity program.
All subjects performed an incremental test to exhaustion on a cycle ergometer.
All subjects performed a right-handed 3-choice button press task , which controlled the availability of repeatable responses.
All subjects performed isometric plantarflexion ramp contractions to assess between-day reproducibility on two separate days.
All subjects randomly received either Uma Jeunesse® or Juvéderm® ) Ultra @number@ on one half of their face.
All subjects received CPMHA in both NLFs at @number@ weeks after treatment in this study and were assessed at weeks @number@ @number@ @number@ and @number@
All subjects underwent 3T whole brain magnetic resonance diffusion tensor imaging.
All subjects underwent a detailed clinical and neuropsychological assessment and structural and quantitative 3T MRI.
All subjects underwent a MRI examination at 3T to obtain a 7minute and 20second resting state scan.
All subjects underwent a pupillometric measurement and performed the Wechsler Memory Scale ( WMS ) and Mini Mental State Examination ( MMSE ) .
All subjects underwent clinical and neuropsychological assessment in addition to diffusion and T1 MRI.
All subjects underwent DTI , 18F 2-fluoro-deoxy-d-glucose , and ( @number@ ) C Pittsburgh compound B positron emission tomography scans.
All subjects underwent DWI of the kidneys using b value of 600s / mm ( @number@ ) in addition to MR urography.
All subjects underwent MRI and DTI scanning.
All subjects underwent @number@.5-T knee MRI with T2 mapping.
All subjects underwent [ ( @number@ ) F ] -fluorodeoxy glucose ( FDG ) positron emission tomography studies.
All subjects underwent resting functional magnetic resonance imaging ( fMRI ) in a @number@ T scanner.
All subjects underwent resting-state functional MRI scans.
All subjects underwent short-term heart rate variability ( HRV ) studies.
All subjects underwent spectral domain optical coherence tomography ( OCT ) and full neuro-ophthalmic examinations.
All subjects underwent symptoms evaluation , oropharyngeal exam , endoscopic fiberoptic nasal examination , and Taste Strips and Sniffin ' Sticks tests.
All subjects underwent VEMP testing via GVS with an intensity of @number@ mA for @number@ ms.
All subjects were administered a comprehensive health history to calculate their FSRP score and a thorough neuropsychological assessment of four cognitive domains.
All subjects were asked not to change their lifestyle during the study.
All subjects were assessed before and after the program on target variables related to the above domains of functioning.
All subjects were clinically evaluated and underwent quantitative MRI.
All subjects were cognitively normal at baseline based on their performance on the Mini-Mental State Examination ( MMSE ) .
All subjects were divided into @number@ groups based on their age ( < 55 years and ≥55 years ) .
All subjects were followed-up until they developed MetS or until @number@ years from the date of entry , whichever came earlier.
All subjects were free of overt cardiovascular disease and were not taking HR-altering medications.
All subjects were included from the Leiden Longevity Study and underwent @number@ Tesla MTI of the brain.
All subjects were patch / photopatch tested for sensitization study by using modified human repeated insult patch test ( HRIPT ) .
All subjects were performed with resting-state functional magnetic resonance imaging scanning.
All subjects were satisfied or very satisfied at day @number@ with similar results at day @number@
All subjects were tested for interleukin ( IL ) -6 , high-sensitivity ( hs ) -PCR , and D-dimer levels.
All subjects without fear of falling had FES scores of @number@ ( maximum score ) .
All substrate specimens were ground flat using a diamond stone and were etched using Scotchbond phosphoric acid etchant ( 3M ESPE ) .
All subtypes of MCI showed immediate improvement post-training relative to controls , with the single non-amnestic subtype showing the most benefit.
All supplements increased strength , especially when combined with resistance exercise.
All surgeries for malignant tumors were performed successfully with no residual disease.
All surgical procedures of balloon dilatation were performed under direct gastroscopic vision.
All surrogates agreed that they would recom mend the FN to other families.
All symptoms were defined according to the standard terminology.
All T1-L5 dry vertebrae ( N = @number@ ) of @number@ individuals were measured and analyzed by age , gender , and ethnicity.
All TB deaths were classified into @number@ groups ( TB-related and non-TB-related ) , based on the underlying cause of death.
All teeth were sectioned in the labio-linqual plane using a diamond blade ( Buechler IsoMet @number@ ) .
All tentacle straps were positioned with a special passer needle.
All testosterone values gradually decreased as the number of MetS components increased.
All tests of statistical significance were two-sided.
All tests were carried out in triplicate.
All tests were repeated @number@ times and the mean of angular errors were obtained.
All the above parameters were significantly associated with BMI-SDS ( p < @number@ ) .
All the anomalous right coronary artery coursed between the pulmonary artery and aorta.
All the articles analyzed patients who were hospitalized for HF , and four of them also analyzed patients with AMI.
All the available clinical parameters within the dataset along with the parameters characterizing the respiratory pattern were used to classify the observations into two groups.
All the blood and CSF samples were obtained from each fasted subject.
All the brain MR images of the patients between @date@ and @date@ in our Radiology Department were retrospectively investigated.
All the coding regions and flanking intronic splice sites of CHCHD2 and CHCHD10 were sequenced.
All the cognitive variables were related to the CDT , accounting for @percent@ of variance.
All the comparisons were carried out according to ROC statistics.
All the control specimens debonded spontaneously after aging.
All the data were analyzed statistically and compared with those in @number@
All the deaths happened in Poland.
All the effects of Arg-I were inhibited by the anti-oxidant N-acetylcysteine ( NAC ) .
All the evaluations were performed prior to autopsy.
All the formulations were stable.
All the IADL and ADL variables assessed were significantly more deteriorated among the malnourished individuals.
All the information obtained may be considered useful to improve the scientific knowledge on human reproduction and to exploit new strategies for detecting oocyte aging.
All the interviews were transcribed in full and analyzed using qualitative study methods.
All the lower values correspond to the study conducted at the nursing home.
All the measured parameters were statistically evaluated.
All the measurements are available in computerized form in www.proyectotarragona.es.
All the measures of multimorbidity and individual diseases were associated with the increased odds of activity limitations.
All the @number@ MCI patients who progressed to AD dementia and only @date@ stable MCI presented pathological CSF at baseline.
All the @number@ patients received middle segment pancreatectomy.
All the other responses , but one , were within two standard deviations.
All the parameters returned to baseline values after the washout period.
All the participants of the study were examined using an AMSAT-COVERT automated diagnostic system designed for rapid topical evaluation of the human functional state.
All the participants realized the Wingate-test before ( P1 ) and after ( P2 ) HISST.
All the participants underwent standardized transthoracic echocardiography using an available system ( iE33 ; Philips ) .
All the participants were assessed with their activities of daily living , gait and balance using various scales.
All the participants were tested for speech perception in quiet and noisy conditions and for speech perception with time alteration in quiet conditions.
All the participants will receive instructions on simple home-based exercises , dietary protein , and vitamin D supplementation ( @number@ μg / d ) .
All the patients of the experimental and control groups received standard care ( educational and entertainment activities ) .
All the patients showed a significant improvement of the erectile function.
All the patients treated without the muscle flap ( Group B ) showed a caudal movement of the lower eyelid.
All the patients treated with the orbicularis oculi flap ( group A ) showed a cranial movement of the lower eyelid , although only minimally.
All the patients were also asked to fill in a specific questionnaire ( beta FAce scale ) .
All the patients were devided into pancreatic fistula group ( n = @number@ ) and non-pancreatic fistula group ( n = @number@ ) .
All the patients were diagnosed definitively and managed successfully with flexible bronchoscopy.
All the patients were examined prior to the onset and in the end ( after one month ) of the corrective treatment.
All the patients were female , aging from @number@ to @number@ years with a median of @number@ years.
All the patients were female , aging from @number@ to @number@ years with a median of @number@ years.
All the patients were male , aging from @number@ to @number@ years with a mean of @number@ years.
All the patients were sent a satisfaction questionnaire or contacted for a telephone interview.
All the patients were treated by the senior authors using the technique described.
All the people are exposed to solar ultraviolet radiation.
All the physical tests , were better in less-than-ten-year groups.
All the proposed means of verification were assessed as feasible with the exception of meeting observations which would require an insider.
All the retinal areas examined demonstrated similar aging effects.
All the SABE cities except Buenos Aires demonstrated a statistically significant association between tooth loss and education.
All the samples scored @number@ for dermal mucin deposits in the reticular dermis.
All the samples were examined for the presence of anti-HEV IgG antibodies by using enzyme-linked immunosorbent assay ( ELISA ) .
All the scores differentiated patients from control subjects.
All these activities of nc886 are undoubtedly independent of mature microRNA or vault RNA.
All these alterations may predispose subjects with SD to an increased cardiovascular risk.
All these are common pathologic events in both obesity and aging.
All these associations survived after corrections for age , gender , and multiple testing.
All these changes deteriorated with disease progression.
All these dietary patterns are associated with reduced risk for cardiovascular disease , among other age-associated diseases.
All these drive tumourigenesis and explain the epidemiological link between obesity and cancer.
All these effects have been associated with induction of OPIDN.
All these effects were blocked by pharmacologic blockade of the thromboxane receptor.
All these effects were most noticeable in old Scn5a ( + / - ) mice.
All these events are key players in age-related cognitive decline such as development of Alzheimer disease ( AD ) .
All these factors may contribute to poor blood pressure control in these high-risk CV patients.
All these facts indicate that age-related macular degeneration may be a vascular disease ( or part of a systemic vasculopathy ) .
All these features should not exclude computational leanness and adaptability to available data.
All these findings shed light on the complexity of metal-related diseases.
All these functions can influence the performance in complex tasks like car driving.
All these ingredients may improve bone health.
All these markers of senescence were distinctly diminished , in a concentration-dependent manner , by Berberine.
All these measures showed the typical increase for music released during the two decades of their lives.
All these molecules have been fully characterized and evaluated against two aggressive tumor cell lines , RCC4 and MDA-MB-231.
All these @number@ cases had progressive ataxia with age at onset ranging from @number@ to @number@ years ( @number@ ± @number@ ) .
All these parameters were significantly higher in girls than in boys.
All these processes were inhibited by preincubation with the FAK inhibitor PF573228.
All these SNPs lie within the same LD block , and are in LD with the previously reported haplotypes.
All these subjects were screened for prevalence of various ECG abnormalities in relation to age by recording resting 12-lead electrocardiogram.
All these symptoms lead to significant changes in mobility with falls and inability to carry on with daily life activities.
All these tests were executed to explore the body capability of the right / left side.
All these variables are correlated and significantly predict hope with the exception of health.
All these variables were assessed at baseline and upon program completion.
All the SN components showed significant differences in the GMV , intranetwork FC , and internetwork FC between the HYC and HOC.
All the studies compared multiple treatments.
All the subjects lived in Sardinia , an Italian island , that has the higher prevalence of centenarians than in other European countries.
All the subjects performed physical exercises at a gym.
All the subjects were interviewed by the Beijing Longitudinal Study of Aging ( BLSA ) , in China , between @date@ and @date@ .
All the symptoms were divided into @number@ groups ( asthenic , psychovegetative , dysthymic , and cognitive symptom-complexes ) .
All the tested materials have strong viscoelastic behavior , showing a linear response for small deformations , followed by a nonlinear behavior for higher deformation.
All the twins had telomere length measured and @number@ had serum levels of interleukin @number@ ( IL-6 ) and C-reactive protein ( CRP ) available.
All this implies the need for a greater number of drugs and an increasing risk of drugs interactions with antiretroviral treatment , particularly protease inhibitors.
All those age-eligible for screening from @number@ to @number@ were included in the present analysis ( n = 3087 ) .
All those cellular transport regulations contribute in the aging suppressor role of Klotho.
All those examined mainly undertook physical activity of low intensity.
All those in AF scored ≥2 on the CHA2DS2-VASc.
All three age groups demonstrated a time-dependent shift of auditory space in the direction of eye position.
All three bottles contained most probably lager type beer.
All three categories of factors in the Andersen model help explain the likelihood of CHC use.
All three components separately , of course , lead to lower quality of life.
All three control groups exhibited strong left-hemisphere advantage in inhibitory syllabic priming , consistent with the known left-hemisphere dominance in lexical inhibition during reading.
All three displayed a severely disturbed ossification of the skull and multiple fractures with prenatal onset.
All three events remained in view until the subject responded.
All three examples illustrate the importance of theory-based evaluations in reducing health inequities.
All three frailty models significantly predicted future mortality among community-dwelling , middle-aged and older European men after adjusting for potential confounders.
All three groups were provided an individual home exercise program throughout the 12-week study.
All three immunosuppressive drugs inhibited the production of IL-2 equally well , whereas the production of IFN-γ was less well inhibited by rapamycin.
All three interventions significantly reduced body weight ( ~14% ) , body fat and waist and hip circumferences to a similar degree.
All three Late Pleistocene samples have a dearth of older individuals compared with Holocene ethnographic / historical samples.
All three programs have fewer than @number@ years of history.
All three species were found in yaks ranging in age from < 1 year , 1-2 years , to > 2 years.
All three studies demonstrate the significant anti-aging effects of SS that are especially suitable for subjects with sensitive skin.
All three studies were judged at unclear risk of bias.
All three surrogate inocula were suitable as ECO157 surrogates for dry aging and acid spray plus dry-aging treatments used by small abattoirs.
All thyroid diseases are in fact more common in women than in men and may interfere with the reproductive system.
All title compounds were investigated for their UV filtering , antioxidant , antifungal , and antiproliferative activities.
All together , these findings elucidate the molecular genetic causes of UHS and shed light on its pathophysiology and hair physiology in general.
All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata.
All training modalities improved body composition , cardiorespiratory fitness , and skeletal muscle strength.
All traits , except reproductive rate , showed strongly positive intersexual genetic correlations and were strongly genetically correlated with fitness in both sexes.
All traits were associated with subjective memory.
All treatments affected immune responses at several time points and also affected BWG , albeit temporarily for the latter.
All treatments demonstrated similar leg muscle hypertrophy and vastus lateralis myofiber-type-specific cross-sectional area ( P < @number@ ) .
All trials involving gait lasted at least @number@ min.
All trials were of poor methodological quality.
All trypsin isoforms degraded type II collagen and produced degradation products of similar sizes as those present in the vitreous.
All tumors were immunoreactive for mammaglobin , S-100 protein , and vimentin.
All Turkish people aged ≥65 years were identified using the Rotterdam municipal register and invited to participate.
All types of studies were considered for inclusion except reviews , conference abstracts , dissertations and case studies.
All ultralongeval subjects were living at home or in a nursing home.
All underwent a personal interview and endorsed quantifiable psychache and resilience scales.
All underwent repeated annual cognitive evaluations using a detailed battery including @number@ tests.
All variables reached high effect sizes , with an effect size of r = 0.64 regarding depressive symptoms.
All variables were independent predictors of outcome.
All veneer porcelain fractures occurred in 6-unit fixed partial prostheses ( P = .002 ) .
All vertebrate lenses share a common set of crystallins from two superfamilies ( although other lineage specific crystallins exist ) .
All veterans aged @number@ years and over who were dispensed medicines for diabetes from July to @date@ were included.
All volumetric measures were corrected for intracranial volume.
All volumetric measures were standardized by intracranial volume as volume ratio.
All volunteers confirmed their willingness to undergo the same procedure again to maintain and possibly improve their clinical results.
All walks were videotaped.
All WAT depots became heavier , and white adipocytes hypertrophied.
All were administered a syntactic-priming and a sentence-completion task under either canonical or noncanonical word-order conditions.
All were assessed before and after the half-mile walking test for visual acuity ( Snellen Optotype Scale ) and heart rate.
All were at high risk of performance bias and some were at high risk of detection or other bias.
All were clinically examined by physicians and nurses using standardized protocols.
All were designed for collection in respondents ' homes by nonmedically trained field interviewers.
All were free of known CVD and cancer at baseline.
All were healthy people.
All were injected bilaterally for nasolabial fold correction with cohesive polydensified matrix hyaluronic acid.
All were @number@ years old or older at baseline.
All were qualified forthe second stage of rehabilitation.
All were recruited in a national general population-based survey of sexual behaviors and interviewed by telephone.
All women completed the Female Sexual Function Index and the Brief Profile of Female Sexual Function.
All women ( mean age @number@ ± SD @number@ ) considered oocyte preservation for age-related infertility.
All women were examined on a random cycle day by a fertility specialist.
All women were premenopausal at baseline , and at the 6-year follow-up , women were in different stages of menopausal transition.
All women were registered with the UK National Health Service ( NHS ) and were routinely linked to information on cause-specific admissions to NHS hospitals.
ALM / body mass index could be most suitable in estimating 10-year mortality risk , but requires specialised equipment.
ALM index was assessed with dual-energy X-ray absorptiometry.
Almost all bankers and @percent@ of the non-bankers still have a desire for a child.
Almost all blood vessels are surrounded by perivascular adipose tissue ( PVAT ) , which has not received research attention until recently.
Almost all features and composite score were positively correlated with known age-at-death.
Almost all healthy weight adults had been healthy weight youth.
Almost all mental illness diagnoses were first made during incarceration ( @percent@ ) .
Almost all of the children had initiated breastfeeding and were still being breastfed when the data were collected.
Almost all of the measured parameters were significantly smaller in the elderly subjects in Heschl's gyrus , planum temporale and gyrus frontalis superior.
Almost all organisms age , and thus animal models can be useful for studying aging.
Almost all parents reported problems in disclosing their child's HIV status because of the fear of social stigma.
Almost all patients diagnosed with epilepsy presented with symptomatic epilepsy.
Almost all patients underwent CT to confirm the diagnosis.
Almost all ( @percent@ ) patients had a complete resolution of the symptoms after changing the treatment.
Almost all were in the clinical range on the measure of psychological functioning.
Almost all were willing to see at least one professional ( @percent@ ) and try prescribed medications or counseling ( @percent@ ) .
Almost half of all children with autism spectrum disorder have average cognitive abilities , yet outcome remains poor.
Almost half of all lung cancer occurs at age > @number@ years.
Almost half of the administrators reported discrimination by patients / clients toward their foreign-born workers.
Almost half of the individuals presented successful aging.
Almost half of the men thought that decreased memory and / or dystymia and anxiousness were related to a male climacteric.
Almost half of them were defended during the boom years ( 2005-2006 ; 2009-2010 ) .
Almost half of the patients in the patient group had a partner.
Almost half of the population reaches moderate impairment ( CKD @number@ ) by @number@ years of age.
Almost half of the respondents expressed concern that free samples may adversely affect subsequent affordability , yet two thirds of respondents provide free samples.
Almost half ( @percent@ ) chose the wrong distance category , and some people misestimated their distance driven by up to @number@ km.
Almost healthy @number@ men and almost healthy @number@ women have made the control groups.
Almost no population-based studies have investigated the relation of stress to cognition or changes in cognition over time.
Almost @number@ million adults in the United States experience some form of osteoarthritis ( OA ) .
Almost @number@ % of the participants had a significant global functional decline over time.
Almost @percent@ ( n = @number@ ) of the sample indicated that an internet-based self-management program would be the best delivery format.
Almost @percent@ of all Cubans live in Havana , demographically and structurally an aging city.
Almost @percent@ of humans present a Toxoplasma gondii positive antibody status and its prevalence increases with age.
Almost @percent@ of mental illnesses were recognized by the @number@ CONCLUSIONS : There is a substantial burden of mental illness among inmates.
Almost @percent@ of participants attended a recruitment event sponsored or supported by CBOs.
Almost @percent@ of patients were exposed to polypharmacotherapy.
Almost @percent@ of people with DM in China experienced catastrophic healthcare expenditure on medications compared with @percent@ in India.
Almost @percent@ required complex periodontal therapy.
Almost sixteen percent ( n = 39 ) had severe osteopenia / osteoporosis concomitant to sarcopenia.
Almost three in five elderly ( @percent@ ) rated their health as poor , and @percent@ had experienced at least one chronic disease.
Almost three-quarters of our study subjects had cardiovascular disease.
Almost two-thirds ( @percent@ ) of PPM users used ≥2 PPM classes.
Almost uniformly , participants did not report decline in either olfactory detection or identification.
A load analysis is performed to compare the finite element results to empirical results from lens stretcher studies.
A load test for anterior pituitary hormones revealed panhypogonadism.
A logistic mixed model will be used to analyze the number of residents who fall during the study period.
A logistic regression analysis was performed.
A logistic regression analysis was performed , adjusting for age , socioeconomic status and proximity of residence to a supermarket using stepwise variable analyses.
A logistic regression model was applied to explore the causes of overtriage and the effectiveness of a modified acuity system.
A logistic regression model was used to assess the predictors of corticosteroid-free remission at week @number@
A logistic regression using the Enter method was performed to investigate associations between predictors and Alcohol Use Disorder Identification Test scores.
A log rank test was performed on KM survival output and a Cox proportional hazard model was used to calculate hazard ratios.
A log recorded trips from home.
A longer anticoagulation period ( @number@ months ) resulted in a higher difference in drug costs , indicating a higher ICER.
A longer follow-up length was associated with an increased creatinine level.
A longer follow-up period with more patients would be valuable in further documenting the procedure.
A longer period of education was associated with greater thickness in a number of cortical regions.
A longitudinal cohort design was used to evaluate the association between alcohol consumption over @number@ years and subsequent changes in arterial stiffness.
A longitudinal descriptive design compared upper limb performance at baseline and follow-up of @number@ women and @number@ men with the late-onset or adult phenotypes.
A longitudinal follow-up study is required to confirm these findings.
A longitudinal model adjusted by age groups was implemented to control for this confounding.
A longitudinal model was developed for mediators of volunteering over time.
A longitudinal observational study using a questionnaire was conducted.
A longitudinal relationship observed between symptoms and activity weakened with age ( P < .001 for interaction ) .
A long post-menopausal period was a risk factor for large soft drusen ( ≥ @number@ μm ) .
A long-standing quest is to define the mechanisms responsible for the mitochondrial dysfunction and accumulation of damaged mitochondria that occur during aging.
A long-term goal of our field is to determine the sequence of pathological events , which ultimately lead to cognitive decline and dementia.
A long-term of BZDs use may cause dependence and abuse.
A long-term prospective study is required to clarify the causality.
Along the NE specific proteins assemble to form meshworks and mutations in these proteins have been described in a group of human diseases called laminopathies.
Along the normal aging process , voice tends to become weak , breathy , and loses projection , which may interfere in the communication process.
Along these lines , the higher the P300 amplitude , the lower the bilateral atrophy ( p = 0.0165 ) .
Along with aging , QDS showed a growing tendency , while IDHAS showed obvious declining tendency.
Along with differential health practices , population variations in this spectrum of risk factors probably contributes to the variable CKD prevalence worldwide.
Along with HIF1α , histone methylases MLL1 and histone acetylase p300 are enriched at the HOTAIR promoter under hypoxia.
Along with rapid advances in human genomics , policies governing genomic data and clinical technologies have proliferated.
Along with sex hormones , other comorbidity may need to be assessed together in relation to cognitive function in the elderly.
Along with the aging society in Japan , the number ofelderly cancer patients is increasing , and hematological malignancy is no exception.
Along with the decrease of TB people's attentions to tuberculosis has been reducing significantly , including the medical personnel.
Along with these changes , surgeons have innovated and evaluated novel procedures for pulmonary resection.
Along with these similarities , there is a difference between sarcopenia and osteoporosis , which is a gender difference.
Along with this continuous rise , there is a significant increase in type @number@ diabetes in this population.
Along with this latter goal , the RCMARs developed and maintain academic-community partnerships.
Alopecia changes mimicked stress-induced premature senescence.
Alopecia impairs the physical and mental health of patients.
A loss of cartilage function and quality is also seen with increasing age.
A loss of function of TDP-43 repressing CDK6 expression may result from altered subcellular TDP-43 distribution.
A loss of genomic imprinting is responsible for biallelic expression of the well-known Insulin-like Growth Factor @number@ ( IGF2 ) gene.
A low arch was associated with a higher leg muscle mass in adjusted models for both men and women ( p < @number@ ) .
A low birthrate and aging society have led to a decrease in the Japanese work force.
A low CBIS score denotes greater dissatisfaction with CBI.
A low dimensional representation of the selected feature vectors show significant clustering behavior corresponding to the subject age group.
A lower but insignificant difference of bone mineral density was observed in females.
A lower cell density indicates a thinner cornea.
A lower CRP level seems to be associated with a more benign clinical course.
A lower degree of conversion was obtained with all antioxidants in SB and EB , except for the EB-Vit.
A lower E2 / T ratio may be protective against developing MetS.
A lower expression of the PDE4B gene may be involved in the neurological abnormalities in subjects with Down's syndrome.
A lower forced expiratory volume in @number@ s was associated with worse Rhythm and Pace , including lower cadence and gait velocity , respectively.
A lower level of fatigue was noticed among patients ≤50 years and ≥71 years of age.
A lower level of social engagement was also associated with a greater cognitive decline.
A lower proportion of sexually active adults had urinary incontinence ( p = @number@ ) .
A lower risk of falls and fractures has been observed in patients who had received physical therapy apart from pharmacological treatment.
A lower score on the MNA scale is associated with a greater likelihood of having lower vitamin D serum values.
A lower value of SampEn indicates lower complexity of COP variability , that is , rigidity , and lower degrees of freedom.
A low incidence of DDs ( @percent@ ) and short ISIs ( @percent@ ) was observed among the @number@ MU trains recorded.
A low LBM has been associated with increased adverse effects from prescribed medications such as chemotherapy.
A low-level , chronic inflammatory process is also present in brain during aging.
A low-level of inflammation is also present in the aging process.
A low ovarian reserve was found in the majority ( @percent@ ) of women in group III and in all women in group IV.
A low serum IGF-I was associated with significantly lower measurements of body composition , such as BMI , skinfolds and WHR.
A low SPPBm was associated with grip strength but not with SMI.
A low value of serum testosterone may be a predictor for mortality in elderly male patients.
Alpha-1-antitrypsin concentrations partially mediate the seasonality of cytokine responses , whereas the effect of vitamin D levels is limited.
Alpha-2-macroglobulin ( α2M ) , a protease inhibitor , is implicated in Alzheimer's disease , atherosclerosis , and other age-related diseases.
Alpha-adrenergic receptor blockers ( α-blockers ) decrease LUTS and increase urinary flow rates in men with symptomatic BPH.
Alpha and δ-tocopherol were not associated with any lung function parameter.
Alpha peaks identified from multiple electrode sites were organized into clusters of similar frequencies whose sex differences and age trends were investigated.
ALP was highly and significantly correlated with BAP both before and after treatment.
ALS causes muscle wasting and atrophy , resulting eventually in respiratory failure and death within 3-5 years of diagnosis.
ALSFRS-R scores correlated with measures of motor function.
ALS-FTD patients showed cortical thinning in regions including the frontal and temporal gyri and the posterior cingulate cortex.
ALS-like phenotypes in animal models are highly dependent on transgene dosage.
ALS mortality rate has increased over time probably due to the aging of the population and decline in rates for competing causes of death.
Also , 3rd order aberration values are of importance , especially coma which also increases with age.
Also , 4-6-year-olds exhibited a poorer processing of orienting cues as indexed by lack of modulation of the N1.
Also , AD is highly heritable , but the heritability of MCI has not been established.
Also , aged women experience worse health than men , as shown by functioning assessment , self-rated health , chronic conditions and functional limitations.
Also , ageing could be characterized as a disturbance in this well-balanced machinery.
Also , aging seems to confer a profibrotic phenotype upon fibroblasts and to increase the severity of the fibrogenic response in non-IPF fibrotic lung disorders.
Also , a greater proportion of male nonresponders was observed ( versus women ; P = @number@ ) .
Also , AIx , aortic SBP , and aortic PP show clearly less than optimal agreement.
Also , a larger word vocabulary was related to longer response duration in the SRT84% condition for the participants with normal hearing.
Also , a lower abundance of SIRT3 , accompanied by an increase in acetylated skeletal muscle proteins , was observed in grandmothers.
Also , analyses were cross-sectional and directionality of associations could not be determined.
Also analyzed age , sex , BMI and the level of postoperative independence ( postoperative independence scale SAP ) .
Also another significant association was observed between the CC genotype and PD ( p = @number@ OR = @number@ ( @number@.252-0.772 ) ) .
Also , Arab older adults are at higher risk of deterioration over time compared with Jewish older adults.
Also , as a society , we should reconsider the highly medicalized stance we take to compensate for age-related losses.
Also , ASC might have an anti-aging effect on photo-aged fibroblasts even at a genetic level.
Also , a sizable subgroup required one or more rest stops.
Also assessed is a function of hyaluronic acid , the major stem cells niche component , as a guardian and controller of stem cells.
Also assessed was the effect of 2-deoxy-D-glucose , the agent attenuating metabolic cell activity , on the depth of senescence induced by Mxt.
Also , a summary of the tool's strengths and limitations in practice and research settings , areas for improvement and future research avenues is provided.
Also at world level one can observe a sharp increase in the proportion of older people.
Also , a unified model of structural changes in a normally aging brain is still lacking.
Also , both gels were injected under ultrasound control in the mid reticular dermis of three subjects.
Also , CD31 expression , an endothelial specific marker , was restored in vivo by DMF.
Also changing are parameters by which outcomes are assessed , shifting toward patient-centered care.
Also , chronic inflammation is closely associated with cardiovascular disease , as well as a broad spectrum of neurodegenerative diseases of aging including AD.
Also citrate synthase activity was higher in trained than in untrained men ( @number@ ± @number@ vs @number@ ± @number@ mU / mg ) .
Also , common comorbidities increase the risk of pharmacologic toxicity and narrow the therapeutic window.
Also , common genetic variants in the human Circadian Locomotor Output Cycles Kaput ( CLOCK ) show associations with ghrelin and total energy intake.
Also contrary to expectations , visual integration resulted in increased hippocampal activation in both age groups , along with increases in PRC and PHC activation.
Also , CR's dementia assessment was informant-based and determined with investigator-administered clinical dementia rating ( CDR ) scale.
Also , CTCAE characterization does not routinely integrate detailed patient-reported and medical outcomes data available from clinically assessed cohorts.
Also , current alcohol users were @percent@ less likely to report poor health.
Also , current understanding of the mechanisms and biomarkers for PTE as well as factors associated with preclinical study designs are discussed.
Also , DBC1 KO mice display higher gluconeogenesis in a normal and a high-fat diet.
Also , depression did not significantly predict PI and the addition of apathy did not increase this prediction.
Also described is the use of the Database for Annotation , Visualization , and Integrated Discovery for interpreting the sirtuin protein-interaction data obtained.
Also , describe the levels of Big Five traits across gender and age.
Also , differentiation of progenitor cells to fibroblasts and increased production of collagen contribute to firmer skin.
Also discussed are metabolism , receptor binding , rationale for safety and suggestions for future work.
Also discussed are the limits of existing research strategies and the future directions of this field.
Also discussed are the normal changes undergone by men as they age and the effects that are expected due to this change.
Also , dovetailing with past work , the depletion effects were limited to prospective memory tasks that are thought to require demanding attentional processes.
Also , doxorubicin did not cause senescent morphology in the absence of serum.
Also , dropouts judged it to be acceptable.
Also dysfunctional organelles , particularly mitochondria , have been implicated in the pathophysiology of several neurodegenerative diseases.
Also , EBR was negatively related to scores on the Montreal Cognitive Assessment test ( MoCA ) test.
Also , elevated neuroticism and decreased agreeableness and openness appear as valuable traits in the description of psychopathology.
Also , endogenous p33ING1 protein accumulates in chromatin in oncogene-senescent fibroblasts and its silencing by RNA interference impairs senescence triggered by oncogenes.
Also , enhancing factors positively associated to it might play a role in improving wellbeing.
Also , expression levels of cAMP and cGMP were significantly lower than those of other two groups.
Also , further exploration of the role of lifetime anxiety disorder in late-life depression may be of future importance.
Also , gene expression in the annulus fibrosus ( AF ) and nucleus pulposus ( NP ) cells changed with aging.
Also , HAM-D was used to assess the severity of depressive symptoms.
Also , heart rate was monitored at 5-s intervals throughout each session.
Also , high body iron levels may contribute to increase the oxidative stress by the generation of reactive oxygen species.
Also , higher FRS was significantly associated with faster decline in walking speed ( P < @number@ ) .
Also , hSuv3 helicase is able to utilize several different nucleotide cofactors including both NTPs and dNTPs.
Also important are mode of delivery , early microbiological exposures , and multiple early atopic sensitizations.
Also important , the spin exercise group demonstrated a high level of adherence ( mean adherence = @percent@ ) .
Also , increased glucose plasma level negatively correlated with SVR ( AOR = 0.98 , p = 0.066 ) .
Also , increasing age is associated with a decrease in severity of the oxidative status , but a decreased chance of pregnancy.
Also , inhibition of eIF2αP may be a suitable means to increase the anti-tumor effects of pro-oxidant drugs through the induction of senescence.
Also in @number@ g / kg males , the incidence of chronic active inflammation of the forestomach was increased.
Also , in spite of the fact that authors consider that determinants might be multi-domain , empirical research usually reduces them to life styles.
Also , in TAT , angiogenic and endothelial parameters exhibited strong positive correlations with age.
Also in the biceps , young spindles were alike adult spindles.
Also , in the photo-aged skin , the dermal collagen density and dermal thickness were increased.
Also intraoperatively , it pointed ; out high-risk nodules more accurately.
Also , in Western blotting , EGCG significantly inhibited the heat-induced expression of AP-1 constituent proteins , c-Jun , JunB and c-Fos.
Also , isonitramine induced insulin without any toxicities and downregulated phosphoenolpyruvate carboxykinase ( PEPCK ) , which catalyzes the first committed step in gluconeogenesis.
Also , isonitramine protected the pancreas from ROS-mediated toxicities.
Also , it would be necessary that future studies more often evaluate cognitive status of depressed elders , as well as cognitive changes after psychotherapy.
Also , leakiness in repairing DNA lesions and uncapped telomeres imposes genomic stress.
Also , linear discriminant analysis was performed to ascertain the cutoff level of LVEF which best predicted cognitive impairment.
Also , L + Z in the macula are related to L + Z in the cortex.
Also male and wealthy elderly were less likely to be engaged in physical activity.
Also maternal internalizing problem scores were higher for boys than for girls among the toddlers.
Also , measures against depression might be effective in reducing falls.
Also mechanical loading ( body mass and muscle tension ) and risk factors for osteoporosis affect bone strength.
Also , membrane proteins and lipids undergo conformational and organizational changes that result in membrane loss , viscoelastic changes and microparticle formation.
Also , missing heritability analyses have estimated that only part of the genetic influence contributing to PD has been found.
Also , mitochondrial DNA ( mtDNA ) encodes mitochondrial electron transport chain proteins and has been associated with altered oxidative stress.
Also mitohormesis , an adaptive response , may arise in vivo to moderate ROS levels , further complicating interpretation of in vivo results.
Also , more studies correct for possible confounding effects to get a better estimate of associations.
Also muscle spindles in the young biceps brachii muscle were examined.
Also , N11 dose-dependently attenuated the transient elevation of intracellular calcium concentration in activated neutrophils.
Also , nine volunteers had in vivo brain scanning using the same MRI protocol.
Also , no dose-dependent associations of the number of cigarettes smoked during pregnancy with childhood retinal vessel calibers were present.
Also none of the children met the criteria for full or partial HUS-associated posttraumatic stress disorder.
Also , none of the haplotypes was found to be associated with CRC , colon or rectal cancers.
Also , no significant differences between the HT and non-HT group were found in BMD and quantitative ultrasound measurements.
Also , @number@ of the subjects performed the ADJ test twice , with different bar lengths.
Also nurses reported on victimization of relational aggression for every participant.
Also nutritional services ( screening ) seem to promote better clinical outcome.
Also nutrition is continually modified.
Also , Offdiagonal Complexity of theta band in young subjects was observed to be significantly different than old subjects.
Also of interest was how spatial separation affected the ability to perform these two tasks.
Also , older adults could maintain high levels of cardiorespiratory fitness as they age.
Also , older adults exclusively showed a relationship between the most difficult bimanual circling condition and a measure of working memory.
Also , older adults had higher levels of Mfn2 in type II fibres compared with young adults.
Also , older adults with diabetes are at increased risk for some geriatric conditions.
Also , older age was associated with steeper declines of memory performance but with less decline of subjective memory.
Also , older people falsely recollect details of never studied stimuli , a clear case of perceptual illusions.
Also , older readers produced more irregular scanpaths than younger readers.
Also , older subjects seem to have difficulties integrating global form and local motion information as efficiently as younger subjects.
Also , our study suggests the need for uniform measures for the assessment of CKD in the elderly to guarantee better sensitivity and specificity.
Also , panic comorbidity may represent an additive risk factor.
Also @percent@ of emergency admissions were for cranial trauma.
Also , @percent@ of @number@ children-years with psychotropic polypharmacy therapy had no psychiatric diagnoses other than ADHD.
Also , @percent@ of the total variance could be explained by the model , with excellent fit statistics.
Also , @percent@ of those with a MNA score < 17 still had a BMI value ≥22.2 kg / m2.
Also , platelet activity suggests a state of abnormal activation ( P-selectin , beta thromboglobulin and platelet factor ) .
Also , pomace extract presents antithrombotic activity.
Also pregnant women can be at risk of developing gestational hypertension and / or pre-eclampsia , which causes complications in nearly @percent@ of pregnancies.
Also , preoperative hematocrit and albumin levels represent reliable predictors of adverse outcomes , suggesting that these markers should be evaluated before BPH surgery.
Also , production of mature naive T cells by the thymus decreases with age.
Also , prostate volume correlated negatively with fT.tPSA correlated positively with E2 and aromatase activity ( E2 / T ) and negatively with fT.
Also provided are the bases for clinical classification and therapeutic principles.
Also , PTD-EGF and FGF1 inhibited UV-induced skin damage.
Also pursued was the association with interstitial lung abnormalities.
Also , rare recessive mutations have been associated with frontotemporal dementia ( FTD ) .
Also , recent challenges that CHPs are facing and strategies to overcome those challenges will be discussed.
Also recorded were weight , smoking status , years of full-time education , and main occupation , serum B12 , folate and creatinine.
Also , recurrent mutations in epigenetic modifying enzymes were identified in AML and linked to distinct DNA methylation signatures.
Also , reducing the quantity of calories and glucose in the diet can confer an increased health-span , including reduced cancer incidence.
Also , reference values are provided.
Also , regression models obtained using combined GM , WM , and PET imaging modalities outperformed models based on single modalities.
Also , research has demonstrated that individuals view snacking as an unhealthy behavior.
Also , respectful and attentive communication may empower patients to convey their values and preferences about their own care.
Also reviewed is the blockade of TG and active removal of EGGL as therapeutic strategies , with the conclusion that both have promise.
Also reviewed were Department of Health and Ageing and Alzheimer's Australia research reports between @number@ and @number@
Also , S4 was significantly more prevalent in those age > 40 years and significantly more pronounced during sleep in those age > 40 years.
Also , serum-starvation prevented senescent morphology caused by nutlin-3a in MCF-7 and Mel-10 cells.
Also , significant improvements in these properties have been observed due to irradiation.
Also , signs of liver distress which accompany metal dysmetabolisms have been shown to be linked to AD.
Also , similar proportions of elderly and younger received dose reductions.
Also , slow-wave sleep predicted less subjective restoration , although adjustment for age attenuated this relation.
Also , some lipodystrophies can be associated with premature aging and precocious cardiovascular disease.
Also , some theories of ageing were introduced.
Also studied were differences between males and females.
Also , subjects in the Mental group showed improvement in agility fitness test and certain survey scales.
Also , suggestions for future research objectives and therapeutical implications are discussed.
Also , telomere shortening is accelerated by NSAID usage especially in H. pylori-negative subjects.
Also TF was lower and ferritin higher in AD.
Also , the 6MWD was significantly higher in men compared to women at baseline.
Also , the ability of confidence to diagnose accuracy of responding improved across rounds.
Also , the ability to decode biological motion , indexing social cue detection , partially mediated age-related variance in the ability to interpret false beliefs.
Also , the a-BT cognitive profile was presented and should prove to be clinically useful for interpretation.
Also , the adverse effects associated to treatment were observed.
Also , the definition , etiology , symptoms , diagnosis and management of UAB were discussed in this review.
Also , the disease-disease association results could be helpful to determine the symptom relationships between neurological and psychiatric diseases.
Also , the disease is more frequently found in men undergoing radiation therapy or surgery for prostate cancer.
Also , the effects of lithium treatment on mtDNA content have never been evaluated in humans.
Also , the expression levels of specific markers for active osteoclasts were decreased when incubated with stMSC-CM.
Also , the extracts at @number@ @number@ and @number@ mg / ml which showed no toxicity were tested for MMP-2 inhibition.
Also , the extracts of eucommia ulmoides Oliver can significantly increase the content of serum NO and reduce the content of ET.
Also , the form of medical provision is diversified , home medical care and nursing care are recommended.
Also , the FPR1 downstream signaling pathways were competitively inhibited by HCH6-1.
Also , the impact of decreasing intellectual activities on the interpersonal difficulties domain of depressive symptoms may be offset by increasing social activities.
Also , the interaction between age and speed was analyzed.
Also , the knee is considered that it could be a suitable site to evaluate body aging.
Also , the Knoop hardness ( KHN ) of young vs old dentin was measured.
Also the mechanisms involved in improving mitochondrial function are considered and , whenever possible , human data is cited.
Also the menopausal symptoms were evaluated by Kupperman menopause index ( KMI ) .
Also , the morphology , the cell distribution and the tendency to hexagonallity are studied.
Also , the Ne decline in the elderly is not due to speed accuracy trade-off.
Also , the Ne-IC contributed to a much lesser extent to the Ne in older than in younger subjects.
Also , the @number@ CST results were significantly higher in younger OA patients ( P < 0.05 ) .
Also , the number of blood capillaries ( per mm ( @number@ ) ) increased with several hundreds in children and adults versus newborns.
Also , the number of cardiac stem cells ( CSCs ) has not accurately estimated in humans during ageing.
Also , the opinions and suggestions from the elderly were analyzed , which shows their perception of the environment in use.
Also the overall mortality is increased.
Also , the package provides tools for simulation and projection of individual trajectories and hazard functions.
Also the pathophysiological relevance of serum carnosinase , the enzyme actively degrading carnosine into l-histidine and β-alanine , is discussed.
Also , the prevalence of epidemiologic research found an incidence of foot problems which is even higher as a consequence of increasing life expectation.
Also , the pro-inflammatory cytokines increase with aging , leading to enhanced myelopoiesis and osteoclastogenesis.
Also , there are at least four clusters of treatment outcomes that are common in geriatric depression , which mirror the neuropsychological and clinical profiles.
Also , there is an obvious link between intracellular reactive oxygen species levels and cellular senescence.
Also , there is controversial data about the metabolic effects of testosterone replacement therapy.
Also , the relation between cancer and senescence is distorted.
Also , the results of elderly and young groups were compared by Mann-Whitney test.
Also , the results showed the increase in percentage of muscle fibers with high oxidative activity during aging.
Also , there was a negative image of end users of this kind of technologies.
Also , there was downregulation of two pathways responsible for apoptosis.
Also , the risk of adverse events related to vaccination are acceptable.
Also , these dysfunctions can be the only observable manifestations of the disorder.
Also , the shorter the time interval between donations is , the higher the frequency of donations.
Also , the unexpected directionality of the results indicates that the WM microstructural correlates of emotional memory show unique characteristics in normal older individuals.
Also , the vesicles that are generated in vitro show a fast and extensive loss of AChE activity , but not of AChE expression.
Also , the widely replicated 102C > T polymorphism in the HTR2A gene showed a statistically significant drug-gene interaction with SSRI use.
Also , they clarify the role of pain-related self-efficacy in this effect.
Also , they showed some signs of accelerated methylation aging.
Also , this paper shows another link between obesity and BC corroborating the current thesis that both diseases are interlinked.
Also , time to PCD , falls , and mortality were assessed.
Also , to investigate how comparable the control groups from ADNI , AIBL , and AddNeuroMed are with five population-based cohorts.
Also , treating young cells with the energy inhibitor rotenone or with H2O2 recapitulated the Ca2 + overstay and calpain inactivation found in old cells.
Also , viral failures , due to poor adherence or to other factors , and drug resistance are investigated.
Also , we did not find a moderating effect of self-efficacy on the relation between the frequency of memory problems and caregivers ' distress.
Also , we examined the association between role transitions and persistence , recurrence , and new onset of drug use disorders.
Also , we found that they predominantly used the \ "flight \ " response whenever confronted with stressors.
Also , weight-bearing activity appears to provide a greater osteogenic stimulus at the distal portions of the leg bones.
Also , we measured the expressions of collagen mRNA and protein using real time RT-PCR and ELISA , respectively.
Also , we noticed that p38 and JNK of MAPK signaling were substantially more activated in aged retina , suggesting stress induction.
Also , we provide further evidence that postural control during quiet standing cannot be used to predict the occurrence of low-back pain.
Also were revealed the dynamics of mentioned elements contents in the hair of the same children in different years.
Also , we show that the model can reproduce seemingly contradicting observations in late-life mortality dynamics.
Also , when CKD is defined based on eGFR and albuminuria , considerably more people are identified than by eGFR alone.
Also , wrinkles on crow's feet measured by PRIMOS COMPACT ( ® ) ( GFMesstechnik GmbH , Germany ) reduced @percent@.
ALS patients were assigned into four subgroups based on their clinical phenotypes.VBM analysis was carried out using SPM8.
ALS prevalence will rise to about @number@.2-9.8 / 100 , 000 person-years in Germany in @number@
ALT activity is influenced by various factors , including viral hepatitis , alcohol consumption , and medication.
ALT activity is not only measured to detect liver disease , but also to monitor overall health.
ALT associated PML bodies containing PML protein was found in telomerase negative cases of RCC.
ALT cells are characterized by heterogeneous telomeres and the presence of extrachromosomal circular double-stranded DNA molecules containing telomeric repeat sequences.
Alteration of dynamic range of modulation to cognitive difficulty has been proposed as a salient predictor of cognitive aging.
Alteration of epigenetic enzyme activity , histone modifications and DNA-methylation is , in fact , typically associated with the ageing process.
Alteration of gene expression by YAP leads to cell proliferation , apoptosis evasion , and also stem cell amplification.
Alteration of metal ion homeostasis is observed both in normal aging and in many neurodegenerative diseases.
Alteration of the DNA methylation level has been linked to modification of the disease progression and instability regulation of certain disease-causing repeats in neurodegenerative diseases.
Alteration of these mechanisms contributes to the inception of various pathological conditions.
Alteration of the Wnt microenvironment plays a significant role in pulmonary aging.
Alterations are present for both hemispheres in either MTLE group , but are more pronounced in right MTLE.
Alterations in Amide I and III modes were consistent with anticipated changes in hydrogen bonding strength as RH increased and upon H → D exchange.
Alterations in autophagic flux are also increasingly being implicated in disease processes that include both atherosclerosis and pulmonary hypertension.
Alterations in autophagy play an important role in diseases including cancer , neurodegenerative diseases , aging , metabolic diseases , inflammation and cardiovascular diseases.
Alterations in central arterial properties play a major role in these hemodynamic changes.
Alterations in cerebrovascular reactivity to CO2 , an index of cerebrovascular function , have been associated with increased risk of stroke.
Alterations in cerebrovascular structure and function may underlie the most common age-associated cognitive , psychiatric , and neurological conditions presented by older adults.
Alterations in CHO are noted among individuals who remain impaired after @number@ months of cART.
Alterations in connective tissue collagen are prominent features of both chronologically aged and photoaged ( ageing because of sun exposure ) human skin.
Alterations in endocrinological functions or in mesolimbic neurotransmission are discussed as possible reasons for this finding.
Alterations in glycosylation can also be acquired and appear to play a role in development and aging.
Alterations in K ( v ) 7-mediated currents in excitable cells result in several diseased conditions.
Alterations in lamins function impact DNA transactions such as transcription , replication , and repair , as well as epigenetic modifications that change chromatin structure.
Alterations in metabolism influence lifespan in experimental models , but data in humans are lacking.
Alterations in microglia functionality are implicated in brain development and aging , as well as in neurodegeneration.
Alterations in motor unit behavior associated with aging deteriorate fine or gross motor performance.
Alterations in NGF , BDNF , IGF-1 , or insulin signaling are implicated in the pathogenesis of Alzheimer disease.
Alterations in pharmacokinetics and pharmacodynamics place geriatric patients at an increased risk of experiencing an adverse drug event.
Alterations in sleep architecture that occur as a part of normal aging will contribute to sleep problems as we grow older.
Alterations in the cutoffs employed may result in discordant clinical classifications of older adults.
Alterations in the innate immune system include decreased proliferation of the peripheral blood mononuclear cells and upregulated monocytic expression of specific stress-responsive inflammatory pathway genes.
Alterations in the pattern of deglutition that are part of healthy aging are called primary presbyphagia.
Alterations in the Ras pathway and its downstream effectors are among the major drivers for uncontrolled cell growth in many cancers.
Alterations in this process have been linked to many human diseases , including peripheral neuropathies and aging-related neurological disorders.
Alterations in vascular function are thought to a key early step in the development of atherosclerosis.
Alterations of Aβ transporters at the neurovasculature may play a role in the disease process.
Alterations of brain network activity are observable in Alzheimer's disease ( AD ) together with the occurrence of mild cognitive impairment , before overt pathology.
Alterations of dopamine receptors and dopamine synthesis are seen in aging , with receptors generally showing reduction and synthesis demonstrating increases.
Alterations of iron levels in the brain has been observed and documented in a number of neurodegenerative disorders including Parkinson's disease ( PD ) .
Alterations of mediators released and / or intracellular pathways may be responsible for age-related ischemic preconditioning reduction.
Alterations of miRNA expression have been associated with Alzheimer's disease ( AD ) .
Alterations of mitochondrial metabolism and genomic instability have been implicated in tumorigenesis in multiple tissues.
Alterations of neurochemical indices of synaptic function are indicators of age-related impairment of central functions , such as locomotion , memory and sensory performances.
Alterations of PCNT gene are associated with dwarfism , cardiomyopathy and other pathologies.
Alterations of spermatogenesis do not seem significantly compromising fertility in the elderly.
Alterations of the cellular redox status have not been previously studied in KS.
Alterations of these activities may explain the pathological modifications observed in disease.
Alterations of the structure and / or amount of glycans present on proteins are associated with many diseases.
Alterations of this pathway have been reported in many cancers.
Alterations to cardiolipin structure , content and acyl chain profile have been associated with mitochondrial dysfunction in multiple tissues in several physiopathological conditions and aging.
Altered age-associated ocular tissue stiffening plays a major role in a significant number of ophthalmic pathologies.
Altered antagonist muscle co-activation and different ankle muscle coordination patterns may account for this finding.
Altered blood pressure ( BP ) circadian profile may be one mechanism underlying this association.
Altered brain AA cascade enzymes could be considered therapeutic targets for future drug development.
Altered brain connectivity - observed in the two training tasks that showed far transfer effects - may be a marker for training success.
Altered cell-cycle activity has been reported in FLT3-ITD-positive AML ; however , the mechanisms by which this oncogene influences cell-cycle activity remained so far elusive.
Altered cell division is associated with overproliferation and tumorigenesis , however , mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit.
Altered chondrogenesis is the most important pathophysiological process involved in the development of osteoarthritis.
Altered DNA methylation has been suggested to be a central mechanism in development , some disease processes and cellular senescence.
Altered epigenetic regulation may potentially influence fetal endocrine programming and brain development across several generations.
Altered expressed genes after NE treatment were identified and further confirmed by RT-qPCR , and by ELISA for protein changes.
Altered expression of circulating miRNAs have been associated with age-related diseases including cancer and cardiovascular disease.
Altered expression of the microRNA-34 family has been determined to be involved in the pathogenesis of many cancers.
Altered glyoxalase-1 ( GLO-1 ) activity and expression is associated with the development of late diabetic complications , malignancy and oxidative stress- and aging-related diseases.
Altered insulin system is associated with major pathological conditions like diabetes and cancer.
Altered levels of EGL-15 / FGFR signaling lead to defects in excretory canal development and function in C. elegans.
Altered mental state is a very common presentation in the elderly admitted to the emergency department.
Altered metabolic patterns provide opportunities to therapeutically target the immune aging process through metabolic interference.
Altered monoaminergic neurotransmitter system functioning has been implicated in both NPS , although their neurochemical etiology remains to be elucidated.
Altered neuronal morphology accompanies functional changes during development , experience , aging , and disease.
Altered patterns of epigenetics / gene expression in aging sperm seem to affect a range of neurocognitive disorders and also metabolic dyshomeostasis across generations.
Altered plasticity not only can trigger maladaptive cascades and can be the cause of deficits and disability but also offers opportunities for novel therapeutic interventions.
Altered processing of food reward in the brain of obese individuals has been suggested to be a possible mechanism related to overeating.
Altered protein N-glycosylation patterns have been found with increasing age and several disease states.
Altered proteolytic processing of the β-amyloid precursor protein ( APP ) is a central event in familial and sporadic Alzheimer's disease ( AD ) .
Altered rRNA transcription and disruption of nucleolar integrity are associated with neurodegenerative disorders , and with aging.
Altering the DNA methylation status of the CX3CR1 gene promoter changed its activity and gene expression.
Alternately , other studies suggest that vitamin C has beneficial effects on exercise-associated dysfunction , inhibiting exercise-induced bronchioconstriction.
Alternately , they should join studies that will help to identify patients with the highest risk those who will clearly benefit from carotid intervention.
Alternate methods of assessing BPSD which consider preferences from clinicians and RACF staff should be further investigated.
Alternating hemiplegia of childhood is a neurological disorder characterized by episodes of hemiplegia , various non-epileptic paroxysmal events and global neurological impairment.
Alternating phases of callosal growth and shrinkage may reflect a permanent adjustment and fine-tuning of fibers connecting homologous cortical areas during childhood and adolescence.
Alternative accounts of these differential transfer costs are discussed.
Alternative approaches are required to quantify pharmacodynamics effects of 11βHSD1 inhibitors in the human brain.
Alternative criteria , common for free movement , such as maximization of smoothness and minimization of force , do not account for the observed data.
Alternative databases need to be used for migrant mortality analyses.
Alternative developmental theories for cognitive function must better account for the diversity of late-life abilities and pathology.
Alternative explanations are discussed.
Alternative explanations such as hemispheric asymmetry reduction and reactive rather than proactive processing in older adults were not supported.
Alternative gene splicing is pervasive in metazoa , particularly in humans , where the majority of genes generate splice variant transcripts.
Alternative gout management strategies should be investigated to reduce the incremental burden of gout borne by the Ontario healthcare system.
Alternative lengthening of telomere takes place even in telomerase-null mice.
Alternatively , ablative fractional resurfacing can be used , with the results , which are comparable to fully ablative lasers with better standard of safety.
Alternatively , aging could be the result of overactive , pathologic autophagy.
Alternatively , a shared mechanism , for example ischemia , may lead to both vascular brain injury and neurodegenerative changes of AD.
Alternatively , changes in self-reports of everyday functions were only weakly correlated with changes in performance on the neurocognitive tests and the everyday tasks.
Alternatively , different key proteins of noradrenergic neurotransmission might be affected.
Alternatively , different limits may result from quantitative evolutionary design , such as a fitness-frailty pleiotropy in men or fertility-frailty pleiotropy in women.
Alternatively , double Holliday junctions can be processed by a reaction known as \ "double Holliday junction dissolution. \ "
Alternatively , further reduction of GABAergic signaling may work as well , although care has to be taken to prevent epileptic seizures.
Alternatively , high activity levels and morbidity might counterbalance such that Tsimane fitness levels and decline are similar to those in industrialized populations.
Alternatively , histone deacetylase @number@ and @number@ bound to the three ERE half-sites , independent of estradiol.
Alternatively , local issues associated with the remote location of many NHS Highland GP practices and patients may have prevented them referring.
Alternatively , model organisms can be included , such as yeast , nematodes and zebra fish.
Alternatively , models can be formulated that imply a smooth change between the two linear parts.
Alternatively , normal / surplus iodide levels can have inhibitory effects on angiogenesis.
Alternatively , one can study the genetics of intermediate traits that are known risk factors for CVD , which can be measured quantitatively.
Alternatively , or simultaneously , they may use different cerebral activation patterns or exert more mental effort.
Alternatively , POS can be labeled with fluorophores , e.g. , FITC , before aliquoting for subsequent fluorescence quantification of POS binding or engulfment.
Alternatively , pro-longevity genes may mediate their effects at the level of protein structure-functional relationships that are beneficially optimized in long-lived species.
Alternatively , reactions with specific aldehydes result in nearly identical products as those found in vivo.
Alternatively , the excess iron may represent a component of brain iron deposition associated with ageing.
Alternatively , the mouse model may not be suitable to validate these rs1042522-associated traits up to the age tested.
Alternatively , α-secretase cleavage generates a soluble and neuroprotective fragment ( sAPPα ) while precludes the production of Aβ.
Alternative splicing of exon @number@ ( E10 ) leads to tau isoforms containing either @number@ ( 3R-tau ) or @number@ ( 4R-tau ) microtubule-binding repeats.
Alternative splicing of exon variants were also examined by using Cufflinks.
Alternatives should be taken into account when possible , balancing the benefits and harms of these medications.
Alternative study designs and analytic frameworks are proposed to better understand the frequency and determinants of these transition pathways.
Alternative treatments include an oral appliance or surgical options.
Although A1R expression was constant during DPSC differentiation , it increased in S-ASC at day @number@ from osteogenesis induction.
Although A673T was observed independently in a Finnish population , this variant was absent in @number@ Asian subjects.
Although aberrant metabolism and deposition of iron has been associated with aging and neurodegeneration , the contribution of iron to neuropathology is unclear.
Although ablative lasers result in major improvements in photodamaged skin , the related postoperative recovery time and side effects are currently unacceptable for most patients.
Although ablative procedures are quite efficacious , they carry significant patient downtime and risks of adverse effects such as scarring and dyspigmentation.
Although absolute differences between the PC and iPad were small and participants preferred the iPad , performance on the PC was faster.
Although accumulation of AGEs is a normal feature of aging , it appears to be significantly accelerated in AD.
Although achieving value at work may be an important predictor of SE , a complete operationalization and definition should include its longitudinal nature as well.
Although a critical role for TDP-43 as an RNA-binding protein has emerged , the regulation of TDP-43 function is poorly understood.
Although additional research is needed , our results suggest that EGb is a potential therapeutic agent for the treatment of OA.
Although AD has long been considered the most common cause of dementia , individuals afflicted with AD commonly exhibit cerebral vascular abnormalities.
Although ADH has been supported in experiments with verbal and nonverbal stimuli , the effects of task or stimulus characteristics on its generalizability remain unclear.
Although adjustment for income , health behaviors , and cardiovascular risk factors attenuated the relationship , the same consistent pattern was observed after adjustment.
Although ADs have been shown to reduce EOLC costs , most people do not have ADs.
Although after-effects are mostly short lived , complex neurobiological mechanisms related to changes in synaptic excitability bear the potential to further induce therapy-relevant lasting changes.
Although a full GA is valuable , it is time-consuming.
Although age-associated changes in kidney glomerular architecture have been described in mice and man , the mechanisms are unknown.
Although age-associated gene expression and methylation changes have been reported throughout the literature , the unifying epigenomic principles of aging remain poorly understood.
Although age-related changes in cancellous bone structure in human are relatively well characterized , few studies have addressed changes in cortical bone.
Although age-related cognitive decline has been associated with cerebrovascular disease , not much is known about the consequences of carotid atherosclerosis on longitudinal cognitive function.
Although age-related deficits in emotion recognition have been widely explored , the nature and scope of these deficits remain poorly understood.
Although age-related hypertension is an established phenomenon , current treatments are only palliative but not curative.
Although aging and senescence are not equivalent , the number of senescent cells increases with aging.
Although aging in rare neurodevelopmental disorders is barely on the research landscape , the field stands to learn much from these older adults.
Although aging is a global phenomenon , there are large differences across countries in both the speed of aging and the current age composition.
Although aging is associated with a decline in bone formation in humans , the molecular pathways contributing to this decline remain unclear.
Although aging is inexorable , aging well is not.
Although aging itself is not a disease , there are many comorbidities that become more common with aging.
Although a great deal of research has examined physical health and well-being of working older adults , less research has focused on cognitive functioning.
Although alexithymia is closely related to normal aging process and poor neurocognitive performance , alexithymia has not been included in these symptoms yet.
Although all demonstrated a decline in BMI , the rate of decline differed according to trajectory for women only.
Although all groups showed a robust conflict effect , there were pronounced age-related differences in behavioral and electrophysiological adaptations to prior conflict.
Although all patients had reduced final adult height SDS , this was more pronounced in patients with salt-wasting.
Although almost @percent@ of individuals with dementia live in developing countries , few clinicopathological studies focus on these individuals.
Although Alzheimer's disease criteria promote the use of biomarkers , their maturity in clinical routine still needs to be assessed.
Although amyloid PET has clearly demonstrated analytical validity , its clinical utility is debated.
Although an active pursuit of health goals is typically adaptive , there may be circumstances in very late life when it is not.
Although androgens are involved in prostate growth during developmental age , their role in the pathogenesis of BPH / LUTS is debated.
Although androgens are known to stimulate hematopoietic cells , it is unknown whether circulating sex steroid hormones affect hematocrit.
Although an epidemiologic association may partially explain this finding , cerebral hypoperfusion and cardioembolism have been advocated as pathophysiological links.
Although an extended study including a larger number of participants is needed to confirm these data , the present results are encouraging.
Although antidepressants are generally effective in decreasing depression , their use in patients with CHD is controversial.
Although anti-inflammatory , anti-atherosclerotic and antioxidant effects have been reported , the antiphotoageing effects of DHAvD are yet to be understood.
Although antiretroviral therapy for HIV infection prevents AIDS-related complications and prolongs life , it does not fully restore health.
Although a number of general trends have been proposed between these traits , there are exceptions that warrant further investigation.
Although aortic stiffening with age is well documented , the interaction between aging and regional aortic PWV is still a debated question.
Although a recent fall is a common trigger , loss of balance confidence also appears independent of previous experience with falls.
Although asbestos is not currently used in South Korea , the incidence of mesothelioma is increasing due to its long latent period.
Although a similar COM momentum was observed at seat-off , how the momentum was controlled differed between healthy individuals and individuals with difficulty in STS.
Although a small number of SPP1-positive pyramidal neurons were observed in S1 , the number was smaller than that in M1.
Although associated with aging , cerebrovascular risk factors , and cognitive impairment , the pathogenesis of WMH remains unclear.
Although associated with bone loss , we did not demonstrate that low bioavailable estradiol translates into worse kyphosis in older men.
Although a strong genetic component has been hypothesized , this has yet to be examined by a genome-wide association ( GWA ) study.
Although a synergism was not observed , BMS-777607 plus AZD8055 increased cancer cell sensitivity toward different cytotoxic chemotherapeutics.
Although attractive in its simplicity , the hypothesis is difficult to reconcile with postmortem analysis of human brains and connectome-mapping studies.
Although Aven orthologs have been identified in most vertebrate species , no Aven gene has been reported in invertebrates.
Although BACH2 has never before been associated with UV-induced damage or ageing , it shows a strong downregulation in both conditions.
Although basal levels were not significantly different , active and total ghrelin levels declined postprandially only in the younger study participants.
Although baseline cognitive performance was related to control beliefs over time , the reverse was not supported.
Although basic research indicates a link between low IGF-1 concentration and depression , this has scarcely been investigated in humans.
Although beetroot consumption has been shown to improve muscle oxygenation and exercise performance in adults , these effects in the elderly has not been addressed.
Although being immortal in principle , stem cells can also undergo aging processes and potentially contribute to organismal aging.
Although both diseases ultimately result in functional disability , differences in the profiles of everyday functioning between the @number@ groups have not been well characterized.
Although both MALDI-TOF MS systems correctly identified isolates to the species level , only Bruker Biotyper accurately identified to the subspecies level.
Although both standard and specialty ONS interventions improve outcomes , findings are inconsistent regarding preferable formulations for the treatment of older adults.
Although both subgroups showed increased cardiac mass , left ventricular mass index was significantly higher in UCRH compared with CRH patients.
Although bottled beer is commonly stored for up to @number@ year , sensorial damage of it is quite frequent.
Although BP control was the primary outcome of these studies , some included secondary outcomes such as healthcare utilization and cost.
Although BPs are generally well tolerated , serious gastrointestinal adverse events have been observed.
Although buried , the @number@ cardiac mutations had no other consistent properties.
Although cachexia may be a component of sarcopenia , the @number@ conditions are not the same.
Although cataract surgery is the most cost-effective intervention , its delivery in developing countries has many issues and challenges.
Although category-specific activation for faces in the ventral visual pathway appears adult-like in adolescence , recognition abilities for individual faces are still immature.
Although CD4 + T lymphocyte count and viral load were unrelated to driving performance , older age was related to poorer driving.
Although cells possess mechanisms to repair or remove damage , they are not @percent@ efficient and their efficiency declines with age.
Although cellular mechanism of ASCs is not completely understood , recent researches have disclosed some of their unique functions as mesenchymal stem cells.
Although cellular models of human disease provide valuable mechanistic information , they are limited in that they may not replicate the in vivo biology.
Although CES-D was negatively associated with sexual behaviour within partnered older adults , there was no association between the negative affect sub-scale and sexual behaviour.
Although CircRNA 100269 is a biomarker used to predict cancer recurrence , its expression and function in gastric cancer ( GC ) remain unknown.
Although claims of posttraumatic stress disorder ( PTSD ) are common in civil litigation cases , it can be additionally complex in older adults.
Although classically considered as harmful , it is now becoming increasingly clear that inflammation can also promote regeneration , if the appropriate context is provided.
Although closed ICUs may promote favorable outcomes under static conditions , they are susceptible to being overwhelmed by patient influxes.
Although complete remission is uncommon , most individuals with schizophrenia experience significant improvement in their quality of well-being.
Although comprehensive health insurance coverage could discourage individual lifestyle improvement due to the ex-ante moral hazard problem , few studies have examined such effects.
Although concealed or dormant in the embryonic stage , they often manifest later in life.
Although COPD is associated with significant disability , there is a growing range of treatment options to assist patients.
Although cosmetic surgery has been widely adopted to rejuvinate skin , we are far from a clear understanding of the mechanisms responsible for skin aging.
Although critically shortened telomeres and defective telomere maintenance contribute to DC pathology , other mechanisms likely exist.
Although cross-sectional studies suggest that cognitive aging starts in midlife , few longitudinal studies have documented within-individual declines in cognitive performance before the seventh decade.
Although CTP-like sequences are encrypted in the LHβ genes of several mammals , the CGβ subunit developed only in primates and equids.
Although currently granted to @number@ million people , it is suspected that some of those eligible do not claim it presenting a non-take-up behavior.
Although data from randomized controlled intervention trials are scanty , these observations are strongly supported by evolving molecular mechanisms which explain the pathogenesis of hyperglycemia.
Although data from those studies are useful , they do not fully address the issues critical to maintaining or maximizing QOL.
Although delayed reaction times ( RTs ) in patients with OSAS have been reported , sensitivity of processing speed has not been adequately assessed.
Although depression in old age is less common than depression in younger populations , it still affects more than @number@ million community-living older adults.
Although design-based stereological methods are generally considered the gold-standard method , all current methods have limitations.
Although designed as a @number@ session , twice weekly intervention , many services in the UK deliver CST once a week for @number@ weeks.
Although detractors of autologous fat transfer persist , facial autologous fat transfer has become widely utilized as one option for volume restoration.
Although developmental dyslexia is often referred to as a cross-modal disturbance , tests of different modalities using the same stimuli are lacking.
Although diastolic velocities changed significantly with exercise , systolic velocities did not.
Although dietary recommendations for managing diabetes have changed greatly over the centuries , recommended protein intake has remained relatively constant.
Although differences in motor performance are well recognized , imaging data elucidating the neuronal correlates are scarce.
Although differentially methylated regions ( DMRs ) displayed a genome-wide distribution , they were enriched on chromosome @number@
Although DNA damage is crucial in aging , a potential role for CDC42 in genotoxic stress remains to be explored.
Although DPCs are common DNA lesions , the mechanism of DPC repair was unclear until now.
Although drinking tends to decline with age in the general population , we know little about LGB older adults ' drinking.
Although drugs have been developed to treat AD symptoms and to slow disease progression , there is currently no cure.
Although DTI is sensitive to the effects of aging , it is not specific to any underlying biological mechanism , including demyelination.
Although dusk was found to be associated with higher infection rates , this may be confounded by the time from positive blood smear.
Although dystrophin-negative mdx mouse models have classically been used to study DMD , phenotypes appear mild compared to patients.
Although each of these aspects has been considered independently , here we evaluate their relative contributions as correlates of age-related improvement in memory.
Although education had a significant positive correlation on older adults ' participation in social engagement activities , income did not show any significant correlation.
Although efficacious in keratinocyte-directed gene transfer , retro- / lentiviral vectors may raise safety concerns when applied in regenerative medicine.
Although efficacy and good safety profiles have been demonstrated , limitations do exist with these systems.
Although emotion regulation modulates the pain experience , inconsistencies have been identified regarding the impact of specific regulation strategies on pain.
Although empirical findings support positive outcomes of family caregiving , less attention has been given to theoretical rationale for positive effects.
Although ER stress and protein aggregation have been implicated in aging , the role of UPR signaling in regulating lifespan remains unknown.
Although essential for initiation , these mutations are not sufficient for the progression of cancer to a life-threatening disease.
Although essential tremor ( ET ) is among the most prevalent neurological diseases , its precise pathogenesis is not understood.
Although evidence , including the present results , suggests a relationship between peripheral hearing and cognition , little is known about the underlying mechanisms.
Although evidence on the association between personality and suicidal ideation in young adults is accumulating , little is known about its relevance in the elderly.
Although falling is a significant problem for older persons , little is understood about its underlying causes.
Although falls are a serious health risk for community-dwelling older adults , their ascertainment has been complicated by issues such as recall and reporting biases.
Although families were tested irrespective of their phenotype , patients with SCA15 had a homogeneous phenotype and were characterized by a slowly progressive cerebellar ataxia.
Although faster gait speed may improve interlimb coordination , it may also increase fall risk in older adults.
Although fatal attempts are frequent in the elderly , research indicated that they rarely present long-term elaboration of suicidal ideation and communicate their intents.
Although fatgrafting is a safe technique , complications may occur.
Although fibroblast senescence has been associated with apoptosis resistance , mechanisms for this have not been well defined.
Although fibroblasts stimulated more collagen expression than ADSCs , they also increased MMP expression.
Although fillers are generally regarded as safe tools for soft tissue augmentation , complications can occur.
Although functional capacity can easily be assessed , the use of additional criteria that anticipate the onset of mobility limitations seems much more advantageous.
Although further evidence is needed , this finding may shed light on the possible time course of neural system dysfunction in healthy aging.
Although further research is needed , physical exercise interventions aimed at improving brain health through neuroprotective mechanisms show promise for preserving cognitive performance.
Although further studies are needed , there may be a role for interventions that can shift vertebral loading in the spine to help prevent fracture.
Although further study is necessary , TECS shows potential to help prevent avoidable vision loss.
Although genes of the insulin signaling pathway likely participate in AP , the insulin-regulated cellular correlates of AP have not been identified.
Although genetic and environmental factors contribute to the development of such disorders , the neurobiological mechanisms involved are poorly understood.
Although genetic factors are involved , less is known regarding the role of anthropometric and hormonally related risk factors.
Although genetic factors are known to play a role in this neuroimmunological condition , the genetic etiology underlying myasthenia gravis is not well understood.
Although genetic risk factors are not easily modifiable , resource deprivation may be more amenable to interventions , which may reduce risk for CD.
Although gerontology as a discipline has historically silenced the lives of marginalized older adults , it has much to learn from these communities.
Although glimepiride maintained apoA-I-mediated cholesterol efflux from RAW264.7 cells , like glibenclamide , it inhibited ABCA1-mediated cholesterol efflux from transfected HEK293 cells.
Although glucose metabolism or insulin sensitivity was not improved , diet-induced liver inflammation was diminished in S467A mice.
Although GRN-deficient mice were viable , GRN ( - / - ) mice were produced at lower than predicted frequency.
Although GSK-3β inhibitors have been investigated as anticancer reagents , precise biological mechanisms remain to be determined.
Although guidelines for routine parenteral supplements of chromium ( Cr ) were published , there remain major concerns about the infusion of excess Cr.
Although H-1 parvovirus is used as an antitumor agent , not much is known about the relationship between its specific tropism and oncolytic activity.
Although habitual exercise has antiaging effects ( e.g. , a decrease in arterial stiffness ) , the relationship between Klotho and habitual exercise remains unclear.
Although health care use was considerable in this sample , most frailty markers were not associated with health care use in this pilot study.
Although health status has improved for all racial and ethnic groups , racial and ethnic disparities remain for many indicators.
Although healthy aging is associated with general cognitive decline , there is considerable variability in the extent to which cognitive functions decline or are preserved.
Although hearing impairment associated with older age was typically construed as a stigma , not all perceptions of aging and hearing impairment were negative.
Although hemostatic therapy with aFVIIa reduced growth of the hematoma it failed to improve clinical outcome.
Although heterosexual men used more services , utilization was largely predicted by service needs and the use of case management.
Although higher IIS predicted greater odds of ADNP ( p < @number@ ) , BMI did not predict IIS ( p = @number@ ) .
Although HIV and aging are independently associated with impaired humoral immunity , immune status in people aging with HIV is relatively unexplored.
Although HIV and aging are two well-established medical and economic domains , their intersection represents an emerging area of study.
Although HIV + subjects had more cirrhosis , liver pathology was not associated with any consistent pattern of brain pathology.
Although HOA increases with aging , the increase may be compensated by decreasing the pupil diameter.
Although hospices appear to be skilled at identifying and providing bereavement services to the at-risk , services do not reach almost half.
Although human infants begin to exhibit disparity-specific responses between @number@ and @number@ months of age , it is not known how relative disparity mechanisms develop.
Although humans measure time using a continuous scale , certain numerical ages inspire greater self-reflection than others.
Although IFN-γ alone had no effect , it potentiated IL-1β-induced ROS production in a time-dependent manner.
Although important confounders were accounted for , observational studies cannot exclude residual confounding.
Although improvements in imaging techniques have allowed us to identify patients with CAA more readily , pathological examination is still essential for a definite diagnosis.
Although IMT was significantly increased in both juvenile and adult overweight / obese subjects , vitD and IMT levels were not correlated.
Although inactive ingredients cause many of these reactions , it is important for dermatologists to be aware of reactions to active ultraviolet filters.
Although infection with Staphylococcus sp. accounts for the majority of cases , other bacteria have been implicated as causative agents of infection of CIEDs.
Although , information is available on the age related neurochemical changes in the mammalian CN similar reports on human CN is still sparse.
Although initially the idea seemed controversial , the existence of cancer stem cells is now well established.
Although in some instances retrotransposition efficiencies slightly diminished , all fusion proteins containing an intact ORF2 were capable of driving retrotransposition.
Although instrumental reminiscence therapy also reduced depressive symptoms , this improvement was not statistically significant compared to the control group.
Although insulin therapy is necessary to treat diabetes , high plasma concentrations of insulin may cause the development of atherosclerosis and accelerate endothelial senescence.
Although intervention goals were met , caregivers had high expectations of their loved one's ability to regain independence.
Although in the Guide reference is frequently made to medical schools , the concept is equally applicable to all forms of education allied to healthcare.
Although intravenous paracetamol has been studied widely in clinical analgesia studies , there is little information on its pharmacokinetics in the elderly.
Although IPSS increased continuously with aging ( from @number@ to @number@ ) , QoL remained unchanged at @number@ over the age groups.
Although irreversible cell-cycle arrest is traditionally considered the major characteristic of senescent cells , recent studies have revealed some additional functions.
Although it has been widely clinically and pathologically evaluated , the topography in LPA is still controversial.
Although it has several protective mechanisms by itself , various physiological and metabolic disorders are detrimental to the proper functioning of the visual system.
Although it is accepted that many factors contribute to age-associated thymic involution , little is known about the mechanisms involved in the process.
Although it is clear that spatial navigation is impaired during aging , the networks responsible for these altered behaviors are not well understood.
Although it is considered reliable for measuring gray matter as a whole , it has never been evaluated regionally.
Although it is generally accepted that ageing is associated with recollection impairments , there is considerable disagreement surrounding how healthy ageing influences familiarity-based recognition.
Although it is known that cell-intrinsic differences in mature T cells contribute to this phenomenon , the factors involved remain unclear.
Although it is nearly @number@ years , since its first pathological identification , there is no effective cure against such aging-associated health concern.
Although it is prudent to prescribe judiciously in patients with these conditions , excessive caution may not be warranted.
Although it is suspected that tissue decline is related to systemic inflammation , the cause and consequence of these aging phenomena are poorly understood.
Although it is well known that aging influences learning , the effect of aging on the stability and plasticity of the visual system is unclear.
Although its expression in intact skin is well characterized , little is known about MIF's role in cutaneous homoeostasis.
Although its positive effects are evident in yeast and mice they still have to be confirmed in humans.
Although Koreans had the fewest self-reported chronic diseases and the least evidence of disease comorbidity , they also had the highest psychological distress.
Although latent variables cannot be directly observed , all cognitive tasks representing a specific latent ability should have a common neural underpinning.
Although leaders have the potential to influence function-focused care , few studies have explored nurses ' perspectives on how leaders influence function-focused care.
Although lens transmittance was decreased for short wavelength light in the older participants , melatonin suppression was not reduced.
Although less frequent than in women , osteoporosis in men is a relatively common problem.
Although less variance in cognitive decline was observed for the similarly aged controls , numerous significant predictors of these differences were identified.
Although lifestyle changes are the mainstay of treatment , to date no drug has specifically been approved for use in persons with NAFLD.
Although listening condition produced no main effects on whole-cortex network organization , a significant age group x listening condition interaction was observed.
Although local retail facilitates walking , our findings suggest that it may increase the odds of depression in older men.
Although longevity was not statistically different between treatments , longevity was strongly related to the compliance of mice in eating the supplement.
Although longitudinal studies are necessary to confirm this hypothesis , our study highlights the importance of different MetS definitions for ED assessment.
Although longitudinal studies can be considered the gold standard to assess the causes of disability , they are costly and often with restricted sample size.
Although long known to undergo functional changes with age , the precise changes occurring within tonsillar B cell populations remain undefined.
Although management of hypertension and atherosclerosis can reduce the incidence of ICH , there are currently no approved therapies for attenuating CAA.
Although many acute care issues for this population are handled via phone , home visits and / or ED use is common.
Although many Alzheimer's disease ( AD ) patients have a family history of the disease , it is rarely inherited in a predictable way.
Although many dystroglycanopathy genes are involved in core M3 processing , the structure and biosynthesis of core M3 glycan remains only partially understood.
Although many frailty scores ( FS ) have been proposed , no single score is considered the gold standard.
Although many of the genetic markers belong to a common pathway , a unifying pathogenetic mechanism is yet to be found.
Although many of these recent findings are still preliminary , they nevertheless open new doors to explore the functionality of the IF family of proteins.
Although many patients with chronic diseases receive their medications from pharmacists , many community pharmacists have not changed their communication style with their patients.
Although many pharmacists are working part-time , this is true for women and men.
Although many programs aim to help older adults age in place , few target both the home environment and individual physical function.
Although many scholars have called for more collaboration between educators , researchers , and practitioners , these challenges can make collaboration difficult.
Although many studies focused on recall of navigational information , the impact of time and type of learning on recall has received little attention.
Although many studies have assessed the effectiveness of yoga in the elderly , little information is available in the literature to support empirical conclusions.
Although many studies have underpinned aberrant neural connectivity , findings related to complexity behavior are still inconsistent.
Although many such networks exist , they are rarely assessed with tools that account for their complexity.
Although many tools have been developed and are used to assess muscle function in older adults , most have important limitations.
Although mean atrophy rates provided by Jacobian integration were smaller than those from segmentation and subtraction of GM volumes , measurement variance was reduced.
Although mean changes were small and unlikely to be clinically meaningful , the magnitude of change varied across subgroups of women.
Although medical advancements have successfully prolonged the human lifespan , the challenge of remediating cognitive aging remains.
Although medications for these disorders are widely used , the treatment mechanisms underlying the illnesses remain largely elusive.
Although memory difficulties are commonly endorsed , few reports of AEs inclusively assess all cognitive domains in detail.
Although microRNA-1 ( miR-1 ) is a known liver cancer suppressor , the role of miR-1 in apoptosis of hepatoma cells has remained largely unknown.
Although microRNAs ( miRNAs ) are known to regulate insulin secretion process , direct regulation of insulin biosynthesis by miRNA has not been reported.
Although MICS has been described in women with breast implants , the documented experience remains limited.
Although mind-wandering is common , engaging in task-irrelevant thoughts can have negative functional consequences.
Although mitochondrial dysfunction is a consistent feature of Alzheimer's disease in the brain and blood , the molecular mechanisms behind these phenomena are unknown.
Although more prevalent , it is not unique to older age-groups.
Although more than @number@ MPV17 gene mutations were shown to be associated with mitochondrial DNA depletion syndrome , the function of MPV17 is still unknown.
Although , more than @number@ yo group had significantly more comorbidities , the complication rates between the groups were insignificant.
Although mortality rates have been falling , the prevalence of atopy has been increasing between generations in Western Europe.
Although most individuals experiencing cognitive impairment ( CI ) reside with a caregiver , an estimated @number@ live alone.
Although mostly studied in the white matter , the cerebral cortex contains significant amounts of myelinated axons.
Although most of them ( @percent@ ) were involved in management of the elderly , only @percent@ incorporated nutritional information component in this activity.
Although most of the species detected in LVC were detected in UTC , some Bacteroides spp. and Faecalibacterium spp. were detected only in LVC.
Although most participants were \ "lurkers , \ " the active participants nurtured community norms and relationships , as reflected in the written dialogues.
Although most primates are social , humans are highly cooperative and social in ways that likely co-evolved with the slow human life history.
Although most research on navigation in aging focuses on allocentric processing deficits , impaired strategy switching may also contribute to navigational decline.
Although most studies claim statistically significant results , the clinical significance of ultrasound technology has yet to be determined.
Although most symptoms primarily appeared along with menstruation change , there are other patients ' experienced climacteric symptoms before menstruation change occurrence.
Although mouse models of Gaucher's disease have been reported from several laboratories , these models are limited due to the perinatal lethality of GlcCerase gene.
Although mouse retina is not prone to develop microaneurysms , Bmi1-deficient mice presented abundant retinal microaneurysms.
Although much has been written about caregiving , few studies document the experiences of providing care as narrated by the caregivers.
Although multiple molecular pathways for early angiogenesis have been identified , little is known about the genetic regulators of secondary network development.
Although muscarinic stimulation may exacerbate depressive symptoms , nicotinic stimulation may improve cognition and neural functioning without a detriment to mood.
Although muscle functional decline precedes age-related changes in other tissues , its contribution to systemic aging is unknown.
Although muscle tissue can be bioengineered using various precursor cells , major limitations still remain.
Although muscular dystrophies are rare , muscle loss affects millions of people worldwide.
Although NAD + has a profound anti-aging and anti-oxidant effects , its effect on humans and use as a dietary supplement needs more exploration.
Although natural selection is widely assumed to operate against long telomeres because they entail increased cancer risk , the evidence for this is mixed.
Although Ndfip1 knockdown led to decreased protein levels of DMT1 + IRE , partially aggravated iron-induced neurotoxicity.
Although nearly all measures of global and regional body composition were significantly reduced following the 12-week intervention , differences were not observed between groups.
Although nephron-sparing surgery may yield decreased long-term morbidity , it is not without its drawbacks , including a higher rate of complications.
Although neuroablative procedures have been performed for the treatment of PHN , their effectiveness was not confirmed by double-blind studies.
Although new assessment techniques have recently become available , body composition is rarely described in infants from low-income settings.
Although no association was found with voxel-based morphometry , FreeSurfer revealed increased gray matter with obstructive sleep apnea.
Although no change in free cytosolic Ca2 + levels is observed , a significantly increased mitochondrial Ca2 + sequestration is found in recipient cells.
Although no group differences were observed at @number@ months for patients , COPE caregivers perceived greater benefits.
Although none of them showed a significant association with CRC , the association of BLM P868L with rectal cancer risk requires further investigation.
Although non-obstructive patients did not show significant intraventricular obstruction at rest , some showed high erythrocyte creatine levels.
Although no remarkable difference on median OS was found , adding TMZ could prevent NCF and QOL from worsening.
Although norms of filial piety traditionally dictate sons as primary supports , daughters predominated as providers of supports to these widows.
Although no specific distribution or pattern of injury was statistically elucidated , we were able to detect some common features.
Although not significantly different , 40-44 years old males also had a lower rate of heat loss compared to younger males.
Although not significant older participants displayed on average a less complex behavior for low and intermediate force levels.
Although not sufficiently accurate , this questionnaire can be used to identify subjects for sleep study assessment.
Although NSAIDs inhibit the exercise-induced satellite cell proliferation , we observed only limited effects on gene expression , and on post-exercise protein synthesis.
Although @number@ drugs were discontinued after CGA , the overall number of drugs used increased from @number@ before CGA to @number@ after CGA.
Although @number@ patients were receiving anticoagulant therapy before the procedure , no intraprocedural or postprocedural anticoagulant-related complications were noted.
Although @number@ ( @percent@ ) heard about smoking related issues during undergraduate courses , only @percent@ received specific smoking cessation training during specialization.
Although numerous papers have recently been published on ablative fractional resurfacing , there is a lack of information in literature on very long-term results.
Although numerous studies have been employed to elucidate the probable issues , the underlying mechanism of the initiation and maturation of autophagy remains unclear.
Although nutrients are integral to muscle metabolism the relationship between nutrition and muscle loss has only been extensively investigated for protein and amino acids.
Although obesity is prevalent worldwide , few studies have investigated how obesity interacts with folate status.
Although OCT has been adopted widely in clinical practice , uncertainty remains concerning its optimal role.
Although odds of frailty in the transitional neighborhood were @number@ times as high as those in the suburbs , the difference was not statistically significant.
Although off-pump CABG is associated with reduced risk of stroke , there are no convincing differences in POCD between off-pump and on-pump CABG.
Although often characterized as ' immature' , the neonatal hemostatic system is nevertheless functionally balanced with no tendency toward coagulopathy or thrombosis.
Although older adults are an interesting population to study in terms of chronic stress , other stress-related diseases can occur throughout the lifespan.
Although older adults benefit from the extensive training , they did not reach the same performance of the young participants.
Although older patients have been underrepresented in cancer clinical trials , there is an emerging body of literature to help guide treatment decisions.
Although older people have much to contribute , one challenging aspect of an aging population is the increasing rate of dementia.
Although older readers had longer eye fixations than did younger readers , the results indicated that the masking effect was comparable for the @number@ groups.
Although one quarter of those choosing testing had high anxiety at baseline , this was not evident at follow-up.
Although only @percent@ of patients reported peripheral artery disease , @percent@ exhibited an abnormal ABI.
Although only @percent@ of the cases were in those aged ≥65 years , they accounted for @percent@ of the deaths.
Although oocyte donation is the best method to overcome age-related infertility , other treatment options may help women proceed quicker toward pregnancy.
Although osteoporosis is known as a silent disease affecting aging populations , its primary symptom remains pain.
Although other functional imaging modalities have taken advantage of population-based inferences using spatially extended statistics , this approach remains little utilized for MRSI.
Although other generalizations of the normal distribution exist , we demonstrate a new alternative that apparently fits human longevity data better.
Although our analysis does not indicate how ethically distribute livers , but it suggests that this be done with consideration for population-based health measures.
Although outcomes for older adults with heart failure have improved over time , mortality , hospitalization , and rehospitalization rates remain high.
Although ovarian neoplasms in childhood and adolescence are rare , the diagnosis should be considered in young girls with abdominal pain and a palpable mass.
Although overall brain properties decline with age , it is unclear whether these declines are associated with visual perceptual learning.
Although OxS is elevated in LOAD patients , its association with multimorbidity seems to be negligible , confirming the existence of strong disease-specific pro-oxidant mechanisms.
Although pain is less prevalent in men than in women , its impact on risk of injurious falls seems to be greater in men.
Although partial recovery appears possible , it can be a long process.
Although participants in both groups showed improvement in CG measures , CGGT participants realized significantly greater improvement.
Although particularly important when planning health and social services , knowledge about their distribution and aggregation at different ages is limited.
Although patients can experience a wide variety of lower urinary tract symptoms , detrusor overactivity is among the most common clinical findings following stroke.
Although @percent@ of patients had some previous knowledge about the examination , @percent@ felt they had further clarification afterward.
Although @percent@ of police reported prior training in working with older adults , only @percent@ rated themselves as knowledgeable about aging-related health.
Although perception and neural representation concurrently declined , one was not predictive of the other.
Although performance in this listening condition was unrelated to pure-tone thresholds , it was strongly correlated with scores on the GIN test.
Although performance varied , as a group , those with AMD were slower and showed more errors in identification than the older controls did.
Although persistent pain predicts similar risk , it is seldom considered in frailty measurement.
Although persons with dementia reported pain less frequently than persons without dementia , the prevalence of pain-related diagnoses was similar.
Although pharmaceutical interventions aimed at lipid lowering substantially decrease the risk of cardiovascular disease , they have much less impact on mortality and longevity.
Although pharmacological control of HIV infection is now possible , HIV-associated neurocognitive disorders ( HAND ) remain intractable.
Although pharmacologic therapies are helpful in treating motor deficits in PD , they do not appear to be effective for cognitive complications.
Although physical activity ( PA ) can prevent falls , most older adults are inactive due to limited motivation.
Although physical and psychological risk factors for ED have been identified , protective factors are yet to be determined.
Although physical fitness is generally very low in older adults with intellectual disabilities ( ID ) , levels may differ across subgroups.
Although physical frailty and cognitive impairment have shown to be related in epidemiological studies , their pathophysiological mechanisms have been usually studied separately.
Although physical symptoms were the most severe menopause symptoms experienced by premenopausal and perimenopausal women , postmenopausal women reported sexual symptoms as the most bothersome.
Although POP can occur in younger women , the peak incidence of POP symptoms is in women aged 70-79 years ( ) .
Although POP can occur in younger women , the peak incidence of POP symptoms is in women aged 70-79 years ( @number@ ) .
Although POP can occur in younger women , the peak incidence of POP symptoms is in women aged 70-79 years ( @number@ ) .
Although POP can occur in younger women , the peak incidence of POP symptoms is in women aged 70-79 years ( @number@ ) .
Although population-based cancer registries are the best answer , regrettably there are still many regions with low accuracy registries.
Although post-inflammatory hyperpigmentation ( PIH ) is the most common complication especially in dark-skinned patients like Asian.
Although postmitotic , one epithelial cell type in the accessory glands , the secondary cell , continues to grow in adults.
Although predictive perinatal variables were not identified , gender-specific relationships between infant growth and SBP were observed.
Although preliminary evidence is promising , additional studies are necessary to determine the causality and biological mechanisms underlying the relationship between loneliness and cognitive function.
Although preliminary , these beneficial immune-modulatory effects of KC-1317 in aged individuals might indicate its employment within a wider age-management strategy.
Although prenatal glucocorticoid exposure is associated with impaired renal development , less is known about effects on the developing heart.
Although previous reviews highlight the multidimensionality of successful aging , a few have focused exclusively on non-biomedical factors , as was done here.
Although previous studies have investigated the short-term clinical and histological results , there have been no studies to investigate longer-term changes.
Although previous studies have reported some factors related to ligamentum flavum hypertrophy , its etiology is still unclear.
Although previous studies indicate that cognitive control of speech perception is subject to developmental changes , its exact developmental trajectory has not been described.
Although previous studies showed that testosterone deficiency is positively correlated with cognitive impairment and insulin-resistant obesity , several studies demonstrated contradictory findings.
Although primarily characterized by degeneration of the limb muscles , cardiomyopathy is a major cause of death.
Although primarily considered a disorder of the elderly , emerging evidence suggests the antecedents of osteoporosis are established during childhood and adolescence.
Although primarily determined genetically , chronotype changes with advancing age towards a more morning-type ( M-type ) orientation.
Although protein intake was normal , calcium and vitamin D intakes were insufficient in all groups.
Although psychological factors have been identified as an important category concerning PA behavior , knowledge on psychological determinants of PA is still inconclusive.
Although psychophysical studies on age-related changes in pain perception have been conducted over more than @number@ years , meta-analyses are still missing.
Although p.Y179C and p.G396D are the two most prevalent MUTYH variants , more than @number@ missense variants have been detected.
Although quality appears to be uniform across different patients , these results provide targets for quality improvement initiatives.
Although rarely acknowledged these associations do not dictate causality.
Although RBP aggregation in disease has been extensively characterized , it remains unknown how the process of aging disturbs RBP dynamics.
Although reaction time was influenced by age , no significant results on post hoc analysis were detected.
Although recent structural work has improved our understanding of these enzymes , their catalytic mechanism is still not well understood.
Although recent studies suggest that somatic mosaicism is widespread during normal development and aging , its implications for heightened disease risks are incompletely understood.
Although regenerative medicine encompasses many components , tissue engineering and stem cell technology are generally considered the two key players.
Although reported medication adherence rates were high , participants also cited several barriers to maintaining adherence.
Although report of self-neglect is more common among black older adults , the racial / ethnic differences in mortality remain unclear.
Although research has found that sexual activity declines with age , most of this literature examines people in long-term marriages.
Although research has identified age-related changes in neural recruitment during emotional memory encoding , it is unclear whether these differences extend to retrieval.
Although research in cell culture has shown promising and positive effects of resveratrol , evidence from rodents and humans is inconsistent.
Although research misconduct occurs and contributes to this shortcoming , it is not the only important factor.
Although respondents identified some practical barriers to informed consent , consenting arrangements were considered workable.
Although resveratrol supplementation in theory is a promising therapy in this patient group , there are no studies evaluating its effects.
Although retinoic acid ( RA ) has been implicated as an extrinsic signal regulating forebrain neurogenesis , the processes regulated by RA signaling remain unclear.
Although revascularization is successful in resolving apical periodontitis , multiple studies suggest that it alone does not support pulp-dentin regeneration.
Although RFs have been known for many years their origin and significance remain elusive issues.
Although rodent microglia are often used in studies investigating microglial function , there are important differences between rodent microglia and their human counterparts.
Although ROS signals are typically associated with cellular injury , these signaling pathways are also critical for maintaining cellular health at homeostasis.
Although sarcopenia was uncommon , presarcopenia was highly prevalent in midlife and older HIV-infected males.
Although self-rated personality traits predict mortality risk , no study has examined whether one's friends can perceive personality characteristics that predict one's mortality risk.
Although serotonin transporter activity plays an important role in determining PSL , the observed correlations indicate that other factors may predominate.
Although serum AGE level is negatively associated with grip strength in elderly people , it is unknown whether this association is present in adult males.
Although several AGEs have been detected in the human lens , the contribution of individual glycating agents to their formation remains unclear.
Although several benefits have been attributed to MMS usage , there are likewise risks of use , including injuries and even deaths.
Although several distinct synthetic PAK1-blockers have been recently developed , no FDA-approved PAK1 blockers are available on the market as yet.
Although several hierarchical clustering-based methods have been proposed , they vary in distance and linkage methods and have not yet been rigorously compared.
Although several hypotheses were suggested , yet unclear is the mechanistic link between these two phenomena.
Although several methods are available to measure brain volumes , improvements in speed and automation are required.
Although several reviews have highlighted the lack of knowledge and research on the topic , there still remain gaps in the literature.
Although several studies indicate that gum chewing is thought to improve cognitive function , it remains debatable whether gum-chewing does in fact improve cognitive function.
Although several studies of inpatient non-ICU diabetes management have been published , few include older patients.
Although several ubiquitin ligases for PTEN have been identified , the deubiquitylase for de-polyubiquitylation and stabilization of PTEN is less defined.
Although severity scores at day @number@ were not available for all patients , disease severity tended to be worse for patients with AH + HCV.
Although sharing some features in anabolism regulation , PKCβ and FTO have not been investigated together ; therefore , their relationship has not been established.
Although signs and symptoms are similar to those in younger patients , diagnosis can be challenging due to presence of coexisting conditions in this population.
Although simple studies may suffice for many patients , there are a few who need more detailed assessment with polysomnography.
Although SIRT1 contributes to aging and metabolic disorders , its role in cancer progression and therapeutic responses remains controversial.
Although sirtuins appeared as a Janus-faced enzymes selective modulators of their activity could be helpful in treatment of several age-related diseases.
Although sleep disturbance is common among the elderly , such elderly patients have been considered difficult to treat because the underlying mechanisms are complicated.
Although sleep has been shown to be altered in MCI and AD , little is known about sleep in SCD.
Although smaller , the education-related difference in white matter volume appeared in areas connected to the education-related difference in gray matter volume.
Although smoking and obesity have driven these trends , changes in the diagnostic criteria may have also contributed to the age-period-cohort effects.
Although social workers are well positioned to address nonmedical needs , their role in healthcare environments to address nonmedical needs is limited.
Although soft-tissue of the columella may have both functional and aesthetic implications , it is a topic not often discussed in the rhinoplasty literature.
Although somatic aging has been studied in both worms and humans , mechanisms regulating reproductive aging are not yet understood.
Although some clinical trials of exercise interventions demonstrate positive effects of exercise on cognitive performance , other trials show minimal to no effect.
Although some genetic loci have been associated with longevity , most of them are difficult to replicate due to ethnic differences.
Although some HIV-dedicated treatment centers offer comprehensive medical services , other models of HIV care potentially exist and should be developed and evaluated.
Although some individual aging-related genes have been the subject of intense scrutiny , their analysis as a whole has been limited.
Although some nonessential food components have shown health benefits and are safe , validated biomarkers of disease risk reduction are lacking for many.
Although some of them were amnestic MCIs , this group was not the most frequent.
Although some parameters of metabolic syndrome are usually measured in a medical setting , checking body weight is usually done by the patients.
Although some specific antiretroviral medications have been linked to disease development , traditional risk factors ( e.g. , smoking ) have major roles.
Although some studies have evaluated proprioception of the knee joint , the reproducibility of methods has rarely been investigated.
Although some tools have stronger evidence than others , this review supports using different and focused assessment tools together for specific medical conditions.
Although species longevity is subject to a diverse range of evolutionary forces , the mortality curves of a wide variety of organisms are rather similar.
Although SST and QC have received a lot of attention in the proteomic community , the currently used statistical methods are limited.
Although stem cell biology has attracted intense attention , the role of proteasome in stemness and its age-dependent deterioration remains largely unclear.
Although stem cell research is a rather new field in modern medicine , media soon popularized it.
Although still underrepresented , older donors contributed more in @number@
Although strains DU1301 , DU7433 , and previously published strain DU43320 carried unrelated plasmids , their transconjugants exhibited similar antimicrobial resistance profiles.
Although structural path length and clustering appeared normal in children with FLE , structural modularity increased with stronger cognitive impairment.
Although structure-function details for this myopathy are evolving , function is undoubtedly driven by sequence variations and post-translational modifications in sMyBP-C.
Although studies have reported that adipokines and inflammatory cytokines are necessary for the development of BE , their role is controversial.
Although studies of dietary and growth factor restriction have been highly informative regarding the aging process , they are both unrealistic for human application.
Although such a common pathology , there are no current guidelines for the first-line treatment of dry AMD.
Although such studies seek families that are exceptionally long lived , they also need living members who can provide DNA and phenotype information.
Although SU patients showed a better adherence to quality indicators , overall compliance was unsatisfactory.
Although survival estimates were much lower for elderly patients in both countries , differences in age patterns were observed for some cancer sites.
Although survival increased greatly for nHw with myeloma between 1998-2001 and 2006-2009 , smaller increases were observed for people of other ethnic groups.
Although survivors exhibited diminished ovarian reserve , these markers were not independently associated with total QLACS score.
Although T2D is associated with cognitive deficits , it recapitulates the patterns of relationships between cognitive performance and demographic characteristics seen in non-T2D diabetic samples.
Although T cell alterations play a significant role in age-related humoral immune changes , alterations in B cells also occur.
Although T cell defects occur , defects in B cells play a significant role in age-related humoral immune changes.
Although techniques and technology evolve continuously , hyaluronic acid ( HA ) dermal fillers continue to dominate aesthetic practice.
Although telomere length is implicated in cellular aging , the evidence suggesting telomere length is a biomarker of aging in humans is equivocal.
Although testosterone-replacement therapy is available , there are undesired side-effects.
Although testosterone substitution needs to be carefully monitored , there is no clear evidence of increased risk of prostate cancer or cardiovascular disease.
Although the association between older age and surgical complications is well known , most anesthetists and surgeons do not measure physical and cognitive function preoperatively.
Although the awareness , treatment and control of hypertension improved significantly , the values of these variables remained low.
Although the body adapts in some ways to starvation , metabolic stress in patients causes increased protein turnover and loss of lean body mass.
Although the body can synthesize L-arginine , exogenous supplementation may be sometimes necessary , especially in particular conditions which results in depleted endogenous source.
Although the BOS phenotype fit , the presence of the variant in reference population databases introduced ambiguity in result interpretation.
Although the cause of sporadic inclusion body myositis is unknown , GNE myopathy is associated with mutations in GNE.
Although the causes of PD are still not understood , aging is a predisposing factor and metabolic stress seems to be a common trigger.
Although the chance of developing Alzheimer's disease increases with age , it is not a natural consequence of aging.
Although the clinical manifestations are nonspecific and may overlap , they may assist in diagnosis of some types of ovarian tumors.
Although the contribution of wasting to the classification of underweight was relatively constant , the contribution of stunting increased as the children grew.
Although the count in group C decreased at week @number@ the count in group F increased.
Although the decline should lead to reduced action integration in older adults , we found equivalent integration in both young and older adults.
Although the development of facial wrinkles happens earlier and is more severe in men , perimenopause seems to particularly affect development in women.
Although the diagnostic work-up is basically the same in young and in elderly patients , therapeutic strategies vary considerably.
Although the effects are very promising , the underlying mechanisms of atDCS are still not clear.
Although the effects of aging on the neural correlates of schizophrenia have been researched for many years , no clear conclusion has been reached.
Although the etiology of ALS remains poorly understood , abnormal protein aggregation and altered proteostasis are common features of sporadic and familial ALS forms.
Although the etiology of PD remains largely unknown , it is now clear that genetic factors contribute to the pathogenesis of the disease.
Although the etiology of sALS remains unknown , genetic variants are thought to predispose individuals to the disease.
Although the etiology of slowly progressive TIN was unclear , glucocorticoid and immunosuppressant therapy improved his kidney function.
Although the exact molecular mechanisms that regulate neural stem cell proliferation and differentiation are largely unknown , several factors have been shown to affect neurogenesis.
Although the exact reason is unknown , lens protein aggregation may be triggered by increases in PTMs such as D-β- , L-β- and D-α-Asp isomers.
Although the examples focus on targeted proteomics , the statistical methods in this manuscript apply more generally to quantitative proteomics.
Although the factors responsible for diminished oocyte quality remain to be elucidated , the present review focuses on the potential role of impaired mitochondrial function.
Although the field of frailty research has expanded rapidly , it is still a nascent concept within the clinical specialties.
Although the first generation of NAMPT inhibitors has entered clinical trials , disappointing outcomes suggest more powerful and specific inhibitors will be needed.
Although the functional significance of DAT1 VNTR is less defined , our results point to a potential influence of SLC6A3 on startle magnitude.
Although the function of miR-9 has been well characterized in neural progenitors , its role in dendritic and synaptic development remains largely unknown.
Although the heritability of depression is estimated to be substantial , single nucleotide polymorphism-based genome-wide association studies of depressive symptoms have had limited success.
Although the high prevalence of obesity ( @percent@ ) , only @percent@ of obese people were sarcopenic.
Although the hippocampus experiences age-related anatomical and functional deterioration , the effects of aging vary across hippocampal-dependent cognitive processes.
Although the hormone doses are lowered and percutaneous administration route is favored upon aging , stopping the medication is not recommended.
Although the human genome has @number@ ALDH genes , one ALDH emerges as a particularly important enzyme in a variety of human pathologies.
Although the impact of aesthetic unit separation is clinically apparent , its fundamental role in perceived facial aging has not yet been defined empirically.
Although the impact of reduced RBCLS on anemia is recognized , it is still a subject that is not well researched.
Although the importance of Brucella T4SS is clear , little is known about its interactions with host cell structures.
Although the incidence is lower in individuals of Chinese and Korean ethnicity , their disease burden is not low because of population aging.
Although the incidence of hip fractures is decreasing , the overall prevalence continues to increase because of an aging population.
Although the increased lifespan of our populations illustrates the success of modern medicine , the risk of developing many diseases increases exponentially with old age.
Although their populations are growing in number and life expectancies are extending they have different trajectories of economic growth , epidemiological transition and social change.
Although the Lifelong Communities Initiative is based on established guiding principles , little information exists regarding the realities of moving from policy to implementation.
Although the links between these factors and cognitive deficits are frequently reported , their joint impact on healthy adults is rarely investigated.
Although the literature shows modest results , small sample sizes limit interpretation.
Although the magnitude of the correlation coefficient was modest , tremor severity was higher with each passing decade.
Although the majority of operationalizations reveal a biomedical focus , studies increasingly use psychosocial and lay components.
Although the majority of variants exhibited intermediate complementation relative to the wild type , some variants severely interfered with this complementation.
Although the MAQ and RSQ are believed to be measuring similar constructs , they are derived from different theoretical perspectives.
Although the mechanism of conjugation of SUMO to proteins is analogous to ubiquitination , it requires its own , specific set of enzymes.
Although the mechanism underlying this inefficacy is unknown , other repair pathways are inactivated by methylation with aging.
Although the membrane pacemaker theory given by Hulbert provides a viable explanation but there are still some unanswered questions.
Although the mouse does not readily exhibit clinical signs of OPIDN , it displays axonal lesions and expresses brain AChE and NTE.
Although the mtDNA has a high mutation rate , only milder , potentially adaptive mutations are introduced into the population through female oocytes.
Although the mutation responsible for this syndrome has been deciphered , the mechanism of its action remains elusive.
Although the native HA molecule is without specificity of species and organs , synthetic cross-linked gels have differences in chemical composition and three-dimensional structure.
Although the natural ligand of the Glucocorticoid Receptor , glucocorticoids ( GC ) represent only some of the multiple ligands for GR.
Although the nature of causality has captivated philosophers and scientists since antiquity , the neural correlates of causality remain poorly understood.
Although the need for some TPR mechanisms may vary , our experience recommends incorporating dissemination as a central TPR mechanism.
Although the negative hallucination has an anti traumatic function in elderly people fighting against mental pain , it still represents a deficiency in symbolization.
Although the neighborhood identity had no interaction with living arrangement , it also contributed to elders ' mental health.
Although the neural correlates that underlie abdominal pain have been investigated , so-called brain processes involved in modulating \ "gut feelings \ " remain unclear.
Although the neurodevelopment of empathy from childhood to adolescence has been documented , no study has yet examined it across a life span aging perspective.
Although the number of older adults is rapidly expanding , the number of healthcare professionals trained in geriatrics is small and declining.
Although the number of pharmacy school graduates has increased , most graduates are women , many of whom may choose to work part-time.
Although the own-age effect was observed for older adults , face age did not interact with lifestyle activities.
Although the pathogenesis of AMD remains unclear , genetic factors have been implicated in the condition.
Although the pathogenesis of Cockayne syndrome has remained elusive , recent work implicates mitochondrial dysfunction in the disease progression.
Although the pathophysiology is incompletely understood and current therapeutic strategies are limited , identification of diastolic dysfunction is important.
Although the pathophysiology of PTSD is not well understood , the €4 allele is related to reduced resilience of the brain to insult.
Although the pedometer can automatically store the most recent @number@ days ' performance , the participants were not informed of this function of the pedometer.
Although the physiological aging is accompanied by morphological changes , the dysfunction of membrane transporters could also lead to neurodegenerative disorders.
Although the presence of low T has been identified , few studies have assessed the presence of androgen-deficient symptoms.
Although the prevalence is relatively lower in Asians than in Westerners , the prognostic impacts on stroke and mortality in Asians are comparable.
Although the prevalence of CHCs significantly increased with increasing age , only hypertension and cancer were significantly associated with years postinjury.
Although the project was successful , further studies are needed to determine if similar findings could be expected in other communities and populations.
Although therapies that inhibit tumour angiogenesis have been highly successful for tumour therapy , most patients eventually develop resistance to this anti-angiogenic therapy.
Although , the real scope of cancer in Sudan is not known , the reported cases have increased from @number@ in 1967-6303 in @number@
Although there are a small number of attempts to assess the skin aging , they identify only one of the previously classified skin aging groups.
Although there are concerns regarding long-term sunscreen safety , the advantages of sunscreen use are far more compelling.
Although there are differences between the pathobiology of normal aging and the phenotype of Werner syndrome , the clinical age-related changes are similar.
Although there are differences in the participants ' interaction with the two devices , the effect of the devices on postural stability is comparable.
Although there are many more questions to be answered , these studies have opened up new avenues for therapeutic interventions in neurodegenerative disorders.
Although there are multiple pathways to successful aging , little is known of what it means to age successfully among black women.
Although there exists an urgent need to develop effective treatments for age-related cognitive decline and neurodegenerative disease , prevention strategies have been underdeveloped.
Although there have been previous studies on LF hypertrophy , its pathomechanism remains unclear.
Although there have been several demonstrations of such transfer effects in young adults and children , they have been difficult to demonstrate in older adults.
Although there is a growing body of research concerning Inuit youth , relatively little is known about elderly Inuit.
Although there is a role for conservative management , surgical drainage remains the mainstay of current therapy.
Although there is evidence for decreasing cross-modality throughout early infancy , it is unclear whether this decline continues to take place throughout childhood and adolescence.
Although there is no effective treatment for POI , therapies for polycystic ovarian syndrome include ovarian wedge resection or laser drilling to induce follicle growth.
Although there is only limited evidence from randomised controlled trials , integrated care seems likely to be beneficial.
Although there is shared glycemic dysregulation , fundamental differences in insulin presence and processing distinguish the two diseases.
Although there is some evidence for an overall effect of WBV on selected balance and mobility measures , its impact remains inconclusive.
Although there is some evidence in younger populations and other types of ulcers , studies in older populations with PUs using sound methodology are needed.
Although the relationship between age-related sleep and psychiatric conditions is a common clinical observation , empirical investigations remain scarce.
Although the repertoires show broadly similar clonotype distributions , the number of observable clonotypes decreases significantly.
Although the results of these trials seem to be contradictory , this approach is also full of promise.
Although there was no association with prescribing , the small sample size provided limited power to examine medication-related outcomes.
Although there were no differences in BZDs as a group , there were significant differences in selected BZDs such as midazolam and diazepam.
Although there were no topographic differences among the age groups , the prolonged PI and associated ERPs suggest a relative age-related deficit in inhibition.
Although there were significant reductions in absolute scar size from baseline to @number@ year post-TESI , the effect did not differ by age.
Although there were similarities in depression attributes between the groups , we found several differences in the frequency of certain attributes.
Although the road density could be used as a covariate in modeling , it is an indirect factor on the relative risk.
Although the role of GSK-3β in centrosomes has not yet been clarified , phosphorylated GSK-3β was localised in centrosomes.
Although the role of nutritional deficiency in the development of age-related frailty was suggested long ago , research conducted in this area is relatively recent.
Although the role of SIRT1 in mammalian longevity is not clear , it is expressed throughout the retina , where it may suppress aging.
Although these aspects of sarcopenia have been well studied , the molecular mechanisms leading to its development are still unclear.
Although these biomarkers are useful , several limitations exist.
Although these compounds show significant promise , there is a need to properly understand the mechanisms through which these drugs act.
Although these differences were not significant , most of the histopathological features examined in our study improved after treatment with MAL plus red light.
Although these embryos were still mosaic , the percentage of repaired blastomeres was over @percent@.
Although these exploratory variations are modest , the findings suggest that bed sensors can be used to measure nighttime restfulness following a therapeutic dance intervention.
Although these findings merit follow-up , they are unlikely to have clinical significance given their prevalence in these apparently healthy animals.
Although these multimorbidities contribute to the symptom burden , older persons with HIV tend not to disclose symptoms to their health care providers.
Although these patients often need specialist-directed palliative care , < 10% ever receive these services.
Although the sequential patterns of aging cannot be changed , several age-related factors that contribute to disease risk can be.
Although these residues have a suspected role in protein cross-linking and aggregation , their direct implication has yet to be determined.
Although these treatment modalities are widely used and clinical experiences are positive , large comparative studies are remarkably scarce.
Although these treatments are not meant to replace surgical procedures , patient satisfaction in the majority of studies has been consistently high.
Although the sex did not affect the nutritional status of studied patients , the age significantly influenced it.
Although the simplified scales can distinguish between conceptually different approaches to well-being , further studies are needed to obtain estimates of reliability and validity.
Although the sleep durations did not change with age , the likelihood of falling asleep during the MSLT increased with age.
Although the smell identification test is not performed in ADNI , this finding is consistent with other AD-related olfactory studies.
Although the specific ' at-risk ' subgroups varied by the outcome , men and Malays had consistently higher odds for all three unfavorable outcomes.
Although the speed of recovery cannot be used for initial diagnosis , recovery speed provides a test of diagnostic criteria.
Although the stroke hospitalization rate has declined , in @number@ there were still almost @number@ million hospitalizations for stroke.
Although the strongest correlations were negative and confined to the splenium , the strength and the direction of intelligence-callosal thickness associations varied considerably.
Although the study of body image has been dominated by a focus on negative aspects , recent research interest has turned towards positive body image.
Although the surface expression of IL-15R α-chain was not increased , the transcription factor STAT-5 was preferentially activated.
Although the surgical approaches are relatively straightforward , achieving natural and predictable results require precision and judgment.
Although the Task Force does not make recommendations , it describes its current practice of treatment of CSA in heart failure and hypoventilation.
Although the temporal fossa is a critical area for volume restoration of the aging face , published information is limited.
Although the term sarcopenia was first coined in @number@ its etiology is still poorly understood.
Although the total contact cast is the criterion standard for the pressure redistribution of challenging foot ulcers , in practice it is not often feasible.
Although the transcriptional controls for alternative splicing of isoforms remain unknown , differential signals via isoforms may control plasma-cell generation in humans.
Although the trends are different in the two sub-periods , adjusted prevalence rates also show an increasing trend.
Although the two conditions frequently co-occur , the association of polypharmacy with sarcopenia has not yet been examined.
Although the types of genes that are age regulated vary among different tissues and organisms , some patterns emerge from these large data sets.
Although the utility of this driver is contingent on its spatial specificity , no detailed neuroanatomical analysis of its expression has yet been conducted.
Although the voiding improvement following TURP is well-documented , controversy exists regarding its effect on post-operative sexual function.
Although they agree that the guidelines are useful , they believe the guidelines are not feasible.
Although they are excellent markers of proteolytic disorders , they can also be due to several other mechanisms.
Although they are primary characteristics of the lens , these antioxidant elements also depend on their systemic availability and consumption.
Although they arrived in France as monolingual Spanish speakers , they have since acquired French and now practice their multilingualism in distinct ways.
Although they rarely cause fatal disease , fungi can cause significant injury and illness.
Although the zinc finger transcription factor Wt1 has been linked to female fertility , its precise role in this process has not yet been understood.
Although thiazide-type diuretics are the recommended first-line agents in most cases of uncomplicated hypertension , multiple drug classes have been shown to be useful.
Although this appears to occur through its role in norepinephrine ( NE ) biosynthesis , the extent with which vascular mechanisms are affected are unknown.
Although this applies to multiple organ systems , the current review focuses on the male reproductive system.
Although this daily circadian rhythm is brain-controlled , its mechanism is encoded by cell-autonomous circadian clocks functioning in nearly every cell of the body.
Although this device can be applied quickly and safely , complications do occur.
Although this enzyme is expressed in glutamatergic pathways , its function as a regulator of glutamate neurotransmitter levels is still not well defined.
Although this facilitates clinical practice , it limits comparability between studies and leads to wide differences in published prevalence rates.
Although this fact is well known , little attention has been paid to the effect of decreased prestretch on mechanical response.
Although this finding may be confounded or biased , it seems worthwhile to intensify research on the potential preventive effects of O-DMA.
Although this has been described in males living within industrialized settings , age-related changes have not received similar attention in populations outside these contexts.
Although this ideal has received considerable attention in the behavioral sciences , it has been largely absent within the gerontology field.
Although this implies genetic factors underlying the carcinogenesis , the etiology remains unclear.
Although this is often attributed to deficits in top-down control from a prefrontal cortical source , this has not yet been directly demonstrated.
Although this is still a vision , the benefits of such an approach seem invaluable.
Although this phenomenon also occurs in a regime with standard frailty , the distortions can be more severe under a regime with Barker frailty.
Although this process is fundamentally haphazard and uncontrollable , senescent decline and ageing is broadly influenced by genetic and extrinsic factors.
Although this study did not assess the utility of this tool in clinical practice settings , future studies should do so.
Although this work focuses on CML , the modelling approach can be applied to all types of leukemia and lymphoma.
Although those with Normal Sleepiness had a longer T / S ratio than those with Abnormal Sleepiness , the difference was not statistically significant.
Although Tibetan macaques are Old World monkeys in the genus of Macaca , limited age- and sex-related physiologic data are available for this particular species.
Although tobacco and alcohol exposures are known carcinogens , their association with male breast cancer risk remains ill-defined.
Although traditional Chinese medicine ( TCM ) is widely used , its effect on health outcomes is not well understood.
Although tremendous progress has been made in understanding the effects of age on intestinal physiology and function , significant knowledge gaps remain.
Although UI is more common in elderly than in younger persons , it should not be considered a normal part of aging.
Although underweight continues to be the predominant nutritional problem , there is early evidence of an epidemiologic crossover from underweight to overweight.
Although urinary incontinence ( UI ) can be managed conservatively , it is a principal reason for the breakdown of in-home family care.
Although UR is known to be associated with certain characteristics , few studies have investigated them in France.
Although useful to direct genetic testing , this study results expand the current knowledge of ALS genetics.
Although variability in the transform influenced the respective PDa distribution , it did not affect the measurement's association with breast cancer.
Although various studies have explained the underlying mechanisms in the pathogenesis of HTN , limited information is available on their biomarkers.
Although vascular calcifications are frequently observed as incidental findings in HR-pQCT scans , they have not yet been incorporated into quantitative HR-pQCT analyses.
Although VASH2 has been recently reported to be involved in epithelial-mesenchymal transition ( EMT ) , its precise roles are obscure.
Although visual impairment is often the sole clinical feature , additional and severe neurologic abnormalities also have been documented for this disease.
Although vocabulary diversity increases throughout the lifetime , grammatical diversities follow a different pattern , which also differs between women and men.
Although we do not have enough evidence that elderly people are a particularly susceptible population to developing GBS following ZIKV infection , this is plausible.
Although we do not know everything about aging , we now know enough to start its pharmacologic suppression using clinically approved drugs.
Although we made a number of proposals at the 21st Subcommittee for Aging , the situation has not changed satisfactorily.
Although we observed a decline , salt intake still exceeded recommended levels.
Although widely accepted , there is a growing number of exceptions to this theory , most contingently related to genetic model organism investigations.
Although widely recommended , vaccination against HZ is not routine ; barriers in Asia-Pacific include long-standing neglect of adult immunisation and sparse local data.
Although WMLs are important , their pathogenesis is still unclear.
Although women are more prone to fractures , the mortality rate associated with fractures is higher in men.
Although women live longer lives than men , they tend to have poorer health status.
Although women report that VMS awaken them , polysomnography ( PSG ) studies have not consistently supported this contention.
Although young bilinguals appear to access both languages simultaneously ( i.e. , non-selective access ) , little is known about language selection in older adults.
Although young untrained and older trained subjects had a similar level of VO₂max , older athletes exhibited a larger IB.
Altogether , age-associated chronic low-grade inflammation in male rats did not worsen the body response to bacterial infection.
Altogether , age-related alterations of skin lead to age-related skin fragility and diseases.
Altogether , hADSCs are promising therapeutic cells for TBI , and lncRNAs in the secretome is an important mechanism of cell therapy.
Altogether @number@ articles were suitable for analyses.
Altogether @number@ articles were suitable for analyses.
Altogether , @number@ control ( age range , 71-99 years ) and @number@ AMD ( age range , 71-95 years ) donor eyes were used.
Altogether , @number@ participants over @number@ were free from disabilities and @number@ showed Mini Mental State Examination raw scores ≥ @number@
Altogether @number@ subjects ( @percent@ ) participated in the study ; dentition status data were available for @number@ of them.
Altogether our data elucidate the TERRA landscape and defines critical roles for this RNA in the telomeric DNA damage response.
Altogether , our data redefined the limits of each stage leading to a more reliable determination of the SEC in man.
Altogether , our data show age-related enhanced susceptibility of human SCs to apoptosis , which might be responsible for their reduced response to muscle damage.
Altogether , our data show that integrin β3 subunit is a marker and regulator of senescence.
Altogether , our data underscore a unique replication-dependent repair pathway that leads to the mitochondrial common deletion.
Altogether our findings add new pieces to the understanding of CSB mechanisms of action and to the molecular basis of CS syndrome.
Altogether , our findings indicate that mutant MDM2 is a likely driver of the observed segmental form of progeria.
Altogether , our findings reveal that loss of WRN activity triggers the activation of an ATM-YAP-PML-p53 axis , thereby accelerating cellular senescence.
Altogether , our main findings suggest that Ng is strongly associated with Aβ pathology , whereas NFL is more unspecific.
Altogether , our results identify LKB1 as a DNA damage sensor protein regulating skin UV-induced DNA damage response.
Altogether , our results indicate that SWM-FA contributes uniquely to age-related cognitive performance , and should be considered as a novel biomarker of cognitive-aging.
Altogether our results point to a unique nature of collagen XXVIII within the collagen family.
Altogether , our results reveal that senescent cell-secreted factors exert a TRAIL-sensitizing effect on pretransformed cells by modulating the expression of MYC and CFLAR.
Altogether , our results support the hypothesis that SDC1 might be involved in liposarcomagenesis.
Altogether , our study demonstrates glycation constitutes a novel drug target that can be explored in synucleinopathies as well as in other neurodegenerative conditions.
Altogether @percent@ of female and @percent@ of male persons were assigned to at least one of the three multimorbidity patterns.
Altogether , spermidine represents a cardio- and vascular-protective autophagy inducer that can be readily integrated in common diets.
Altogether the findings show that reduced fracture healing in aging involves decreased proliferation and differentiation of stem cells lining the bone surface.
Altogether , the more potent PPARγ agonist Edaglitazone seems to be a potent antiplatelet agent.
Altogether , the present findings suggest the anti-tumor potential of resveratrol against various types of cancers.
Altogether , these and our previous findings thus suggest generalized vigorous-HPA-related adaptations , although of different nature , throughout the arterial tree.
Altogether , these findings show an important role for IL-3 in supporting the viability of non-hematopoietic systems.
Altogether , these findings suggest that relationships between callosal morphology and cognition are highly dynamic during brain maturation.
Altogether these findings underline a key role of Bmi-1 downregulation in enforcing aging in primary human keratinocytes.
Altogether the self-rating version of the STEP was found to be feasible and useful.
Altogether , these molecules open the door to the research of new neuroprotective strategies.
Altogether , these observations show that several of these RBPs are important and conserved regulators in maintaining liver function.
Altogether , these results extend our knowledge on the cellular modifications associated with E-cadherin down-regulation in breast cancer cells.
Altogether , these results highlight the utility of novel parameters from entire HU distributions that could provide insight into the optimal quantification of muscle degeneration.
Altogether these results provide evidence for asymmetrical differences in stimulus and response conflict processing across adolescence , young adulthood and middle age.
Altogether the studied variables explained @percent@ of the variation in walking distance.
Altogether , the use of @number@ types of cements and @number@ testing methods was reported.
Altogether , this study demonstrates that phosphorylation of p65 serine @number@ augment NF-κB activity and exacerbates various deleterious effects of overnutrition in mice.
Altruism is typically associated with traits or behaviors that benefit the population as a whole , but are costly to the individual.
A luciferase reporter assay and quantitative polymerase chain reaction were utilized to confirm that Cacna2d1 is a target molecule of miR-107.
Alu demethylation in blood cells starts at approximately @number@ years of age , and the degree of Alu hypomethylation increases with age.
Alu elements and long interspersed element-1 ( LINE-1 or L1 ) are two major human intersperse repetitive sequences.
Alu elements are the major interspersed repetitive DNA elements in humans that lose DNA methylation in aging individuals.
Alu hypomethylation was associated with advanced age and lower bone mass density , ( P < 0.05 ) .
A lumbar spinal specimen ( L3-L5 ) was mechanically tested under a quasi-static axial compressive load.
Aluminum is one of the most common metal elements in the earth's crust.
Alveolar development is now believed to continue throughout somatic growth and is adversely impacted by early tobacco smoke exposure.
Alveolar epithelial cells demonstrated expression of both monocyte chemotactic protein ( MCP ) -1 and inducible nitric oxide synthase in juvenile EPPE mice.
Alveolar rhabdomyosarcoma ( aRMS ) is an aggressive childhood cancer for which the cell of origin remains debated.
AL was based on nine markers of physiological dysregulation.
A lytic lesion was treated with teriparatide obtaining progressive disappearance of symptoms as well as bone healing.
Alzheimer dementia is characterized by progressive cognitive deficits and decline in functional ability.
Alzheimer disease ( AD ) and frontotemporal dementia ( FTD ) are @number@ neurodegenerative diseases with differing cognitive and neuropathologic profiles.
Alzheimer disease ( AD ) and other related dementia represent a major challenge for health care systems within the aging population.
Alzheimer disease ( AD ) is an age-related neurodegenerative condition.
Alzheimer disease ( AD ) is a progressive neurodegenerative disorder with associated memory loss , spatial disorientation , and other psychiatric problems.
Alzheimer disease ( AD ) is characterized by progressive hypometabolism on [ ( @number@ ) F ] -fluorodeoxyglucose positron emission tomography ( FDG-PET ) scans.
Alzheimer disease ( AD ) is one of the most common neurodegenerative disorders widely occurring among the elderly.
Alzheimer disease ( AD ) is one of the most prevalent chronic medical conditions affecting the elderly population.
Alzheimer disease ( AD ) is the most common cause of dementia in the elderly.
Alzheimer disease ( AD ) is the most common causes of neurodegenerative disorder in the elderly individuals.
Alzheimer disease ( AD ) is the most common form of dementia among the elderly and is characterized by progressive loss of memory and cognition.
Alzheimer disease is a multifactorial pathology and the development of new multitarget neuroprotective drugs is promising and attractive.
Alzheimer disease is the most common cause of dementia.
Alzheimer disease is the most common form of dementia in the aged population.
Alzheimer patients showed severe deficits to allocate attention to the LE , which could result in a right ear advantage.
Alzheimer's dementia ( AD ) is the most common neurodegenerative disorder , which affects @number@ million people worldwide.
Alzheimer's dementia represents not only problem for the patient but affects the patients ' caregivers as well.
Alzheimer's disease ( AD ) , a chronic and progressive deterioration of memory and other cognitive domains , is the most common form of dementia.
Alzheimer's disease ( AD ) affects almost @number@ million people worldwide.
Alzheimer's disease ( AD ) affects approximately @number@ million Americans.
Alzheimer's disease ( AD ) affects a significant portion of elderly people worldwide.
Alzheimer's disease ( AD ) and depression ( DE ) are common psychiatric disorders strongly intertwined with one another.
Alzheimer's disease ( AD ) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants.
Alzheimer's disease ( AD ) and Parkinson's disease ( PD ) are the two most common neurodegenerative disorders.
Alzheimer's disease ( AD ) and traumatic brain injury ( TBI ) are both significant clinical problems characterized by debilitating symptoms with limited available treatments.
Alzheimer's disease ( AD ) and vascular dementia are the major causes of cognitive disorders worldwide.
Alzheimer's disease ( AD ) and vascular dementia ( VaD ) are the most common causes of dementia in the elderly.
Alzheimer's disease ( AD ) , a progressive neurodegenerative disorder , is the leading cause of dementia in the elderly.
Alzheimer's disease ( AD ) brains are characterized by fibrillar amyloid-β ( Aβ ) peptide containing plaques and associated reactive microglia.
Alzheimer's disease ( AD ) brains exhibit plaques and tangles in association with inflammation.
Alzheimer's disease ( AD ) can be understood in the context of aging of this neuroimmune communication.
Alzheimer's disease ( AD ) can be used as a case study to investigate the application of systems biology to complex disease.
Alzheimer's disease ( AD ) can present with distinct clinical variants.
Alzheimer's disease ( AD ) can present with non-amnestic clinical syndromes.
Alzheimer's disease ( AD ) determines gradual loss of cognition and memory function , eventually leading to clinical manifest dementia.
Alzheimer's disease ( AD ) disproportionally affects women and men.
Alzheimer's disease ( AD ) has a complex and progressive neurodegenerative phenotype , with hypometabolism and impaired mitochondrial bioenergetics among the earliest pathogenic events.
Alzheimer's disease ( AD ) has a complex pattern of inheritance and many genes have recently been reported to contribute to the disease susceptibility.
Alzheimer's disease ( AD ) has a long preclinical phase in which amyloid and tau cerebral pathology accumulate without producing cognitive symptoms.
Alzheimer's disease ( AD ) is a common neurodegenerative disease characterized by amyloid plaque and neurofibrillary tangles ( NFT ) .
Alzheimer's disease ( AD ) is a complex multifactorial disorder with poorly characterized pathogenesis.
Alzheimer's disease ( AD ) is a complex neurodegenerative disease , affecting millions of people worldwide.
Alzheimer's disease ( AD ) is a complex neurodegenerative disorder involving dysregulation of many biological pathways at multiple levels.
Alzheimer's disease ( AD ) is a degenerative brain disease and the most common cause of dementia.
Alzheimer's disease ( AD ) is a devastating disease characterized by synaptic and neuronal loss in the elderly.
Alzheimer's disease ( AD ) is a devastating neurodegenerative disorder characterized by loss of memory and cognitive function.
Alzheimer's disease ( AD ) is a devastating neurodegenerative disorder without a cure.
Alzheimer's disease ( AD ) is a kind of neurodegenerative diseases , the most common cause of dementia.
Alzheimer's disease ( AD ) is a monumental public health crisis with no effective cure or treatment.
Alzheimer's disease ( AD ) is a multifactorial neurological condition associated with a genetic profile that is still not completely understood.
Alzheimer's disease ( AD ) is an age-associated disease characterized by increased accumulation of extracellular amyloid-β ( Aβ ) plaques within the brain.
Alzheimer's disease ( AD ) is an age-related disorder characterized by progressive cognitive decline and dementia.
Alzheimer's disease ( AD ) is an age-related neurodegenerative disease with a global prevalence estimated at @number@ million in @number@
Alzheimer's disease ( AD ) is an aging-related neurodegenerative disease and accounts for majority of human dementia.
Alzheimer's disease ( AD ) is a neurodegenerative condition associated with cognitive loss , behavioural changes , functional ability decline and caregiver burden.
Alzheimer's disease ( AD ) is a neurodegenerative disease characterized by amyloid beta ( Aβ ) deposits , hyperphosphorylated tau deposition , and cognitive dysfunction.
Alzheimer's disease ( AD ) is a neurodegenerative disorder characterized by fibrillary aggregates of Aβ peptide and tau protein.
Alzheimer's disease ( AD ) is a neurodegenerative disorder characterized by progressive cognitive decline and is the most common cause of dementia in the elderly.
Alzheimer's disease ( AD ) is a neurodegenerative disorder involving impaired cholinergic neurotransmission and dysregulation of nicotinic acetylcholine receptors ( nAChRs ) .
Alzheimer's disease ( AD ) is a neurodegenerative disorder that severely jeopardizes the health of aging populations all over the world.
Alzheimer's disease ( AD ) is a neurodegenerative pathology with relevant unmet therapeutic needs.
Alzheimer's disease ( AD ) is an extremely prevalent cause of dementia.
Alzheimer's disease ( AD ) is an irreversible and progressive neurodegenerative disorder.
Alzheimer's disease ( AD ) is an irreversible and progressive neurodegenerative disorder.
Alzheimer's disease ( AD ) is a progressive and fatal neurodegenerative disorder.
Alzheimer's disease ( AD ) is a progressive brain disorder that initially affects medial temporal lobe circuitry and memory functions.
Alzheimerś disease ( AD ) is a progressive irreversible neurological brain disorder characterized by accumulation of amyloid-β , amyloid plaques , and neurofibrillary tangles.
Alzheimer's disease ( AD ) is a progressive neurodegenerative disease that involves numerous cellular and biochemical mechanisms resulting in synaptic alterations and extensive neuronal loss.
Alzheimer's disease ( AD ) is a progressive neurodegenerative disorder.
Alzheimer's disease ( AD ) is a progressive neurodegenerative disorder and the most common type of dementia among older people.
Alzheimer's disease ( AD ) is a progressive neurodegenerative disorder characterized by memory loss and impaired cognitive functions.
Alzheimer's disease ( AD ) is a protein misfolding-based rapid cognitive impairment in the aging brain.
Alzheimer's disease ( AD ) is a representative neurodegenerative disease in which amyloid-β ( Aβ ) deposition causes neurotoxicity.
Alzheimer's disease ( AD ) is a senile dementia with increased incidence in older subjects ( age > 65 years ) .
Alzheimer's disease ( AD ) is a significant and growing health problem in the aging population.
Alzheimer's disease ( AD ) is a slowly progressing form of dementia characterized in its earliest stages as a loss of memory.
Alzheimer's disease ( AD ) is associated with abnormal functioning of the default mode network ( DMN ) .
Alzheimer's disease ( AD ) is associated with alterations in the distribution , number , and size of inputs to hippocampal neurons.
Alzheimer's disease ( AD ) is associated with the unprecedented aging tendency in our world population and has become a significant health issue.
Alzheimer's disease ( AD ) is characterized by a deficit in motor and spatial learning-memory and alteration of non-cognitive behavior.
Alzheimer's disease ( AD ) is characterized by cortical atrophy and disrupted anatomic connectivity , and leads to abnormal interactions between neural systems.
Alzheimer's disease ( AD ) is characterized by early impairments in memory and progressive neurodegeneration.
Alzheimer's disease ( AD ) is characterized by intraneuronal β-amyloid plaques and hyperphosphorylated tau , leading to neuronal cell death and progressive memory losses.
Alzheimer's disease ( AD ) is characterized by the accumulation of extracellular amyloid β-protein ( Aβ ) and intracellular hyperphosphorylated tau proteins.
Alzheimer's disease ( AD ) is characterized by the accumulation of hyperphosphorylated tau and neurotoxic Aβ in the brain parenchyma.
Alzheimer's disease ( AD ) is generally considered to be a disorder primarily affecting memory.
Alzheimer's disease ( AD ) is histopathologically characterized by the presence of senile plaques , neurofibrillary tangles , and synapse loss.
Alzheimer's disease ( AD ) is increasingly considered as a disconnection syndrome.
Alzheimer's disease ( AD ) is one of the most common forms of dementia in the elderly.
Alzheimer's disease ( AD ) is reliably related to the formation and aggregation of amyloid-β peptide ( Aβ ) plaques in the human brain.
Alzheimer's disease ( AD ) is strongly associated with microglia-induced neuroinflammation.
Alzheimer's disease ( AD ) is the leading cause of dementia , affecting approximately @number@ million people worldwide.
Alzheimer's disease ( AD ) is the leading cause of dementia and has no cure.
Alzheimer's disease ( AD ) is the leading cause of dementia and the most common neurodegenerative disease in the elderly.
Alzheimer's disease ( AD ) is the leading cause of dementia , and the most prevalent neurodegenerative disease in the elderly.
Alzheimer's disease ( AD ) is the main cause of dementia in our increasingly aging population.
Alzheimer's disease ( AD ) is the most common and complex neurodegenerative disease in the elderly individuals.
Alzheimer's disease ( AD ) is the most common cause of dementia and a major cause of morbidity and mortality.
Alzheimer's disease ( AD ) is the most common cause of dementia and represents one of the highest unmet needs in medicine today.
Alzheimer's disease ( AD ) is the most common cause of dementia , and there is currently no cure.
Alzheimer's disease ( AD ) is the most common cause of dementia in aging populations.
Alzheimer's Disease ( AD ) is the most common cause of dementia in the aging population.
Alzheimer's disease ( AD ) is the most common dementia disorder of later life.
Alzheimer's disease ( AD ) is the most common form of dementia.
Alzheimer's disease ( AD ) is the most common form of dementia.
Alzheimer's disease ( AD ) is the most common form of dementia.
Alzheimer's disease ( AD ) is the most common form of dementia and exhibits a considerable level of heritability.
Alzheimer's disease ( AD ) is the most common form of dementia and has no effective treatment.
Alzheimer's disease ( AD ) is the most common form of dementia and marked by deposition of amyloid-β ( Aβ ) within the brain.
Alzheimer's disease ( AD ) is the most common form of dementia and the 6th leading cause of death in the US.
Alzheimer's disease ( AD ) is the most common multifactorial mental illness affecting the elderly population in the world.
Alzheimer's disease ( AD ) is the most common neurodegenerative disease influenced by genetic and environmental factors.
Alzheimer's disease ( AD ) is the most common neurodegenerative disorder among the elderly.
Alzheimer's disease ( AD ) is the most common neurodegenerative disorder among the elderly individuals.
Alzheimer's disease ( AD ) is the most common neurodegenerative disorder and there is currently no efficient cure for this devastating disease.
Alzheimer's disease ( AD ) is the most common progressive form of dementia in aged people.
Alzheimer's disease ( AD ) is the most common type of age-related dementia.
Alzheimer's disease ( AD ) is the most common type of dementia.
Alzheimer's disease ( AD ) is the most common type of neurodegenerative disorder , typically causing dementia along aging.
Alzheimer's disease ( AD ) is the most frequent cause of dementia.
Alzheimer's disease ( AD ) is the most prevalent form of dementia in the elderly population.
Alzheimer's disease ( AD ) is the most prevalent neurodegenerative disease in the world.
Alzheimer's disease ( AD ) is the most prevalent neurodegenerative disorder of aging.
Alzheimer's disease ( AD ) is the most prevalent , severe , and disabling cause of dementia worldwide.
Alzheimer's disease ( AD ) patients display hippocampal atrophy , memory impairment , and cognitive decline.
Alzheimer's disease ( AD ) represents an increasing worldwide healthcare epidemic.
Alzheimer's disease ( AD ) represents the most common form of senile dementia and represents a tremendous health problem as the world population is aging.
Alzheimer's disease ( AD ) , the most common cause of dementia , is associated with aging , and it leads to neuron death.
Alzheimer's disease ( AD ) , the most common form of senile dementia , is a genetically complex disorder.
Alzheimer's disease ( AD ) , the most common neurodegenerative disease associated with aging , is still an incurable condition.
Alzheimer's disease ( AD ) transgenic mice have been used as a standard AD model for basic mechanistic studies and drug discovery.
Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Alzheimer's disease and stroke share very similar risk factor profiles and may be prevented with similar modification programs.
Alzheimer's disease certainly represents one of the most relevant neurodegenerative disorders due to its incidence and its huge socio-economic impact.
Alzheimer's disease has also recently come to the forefront of ongoing maladies most typically associated with an aging population.
Alzheimer's disease is a 100-year-old concept.
Alzheimer's disease is a common and important disorder in which hippocampal atrophy is reported.
Alzheimer's disease is a degenerative , progressive and irreversible condition , which affects cognitive functions.
Alzheimer's disease is a devastating neurodegenerative disorder affecting a significant portion of the world's rapidly growing aging population.
Alzheimer's disease is a neurodegenerative disease that is imposing an increasing burden on society , and is the leading cause of senile dementia worldwide.
Alzheimer's disease is an increasingly prevalent disease with @number@ million people in the United States currently affected.
Alzheimer's disease is associated with a substantial economic impact on patients , their caregivers and society.
Alzheimer's disease is associated with synapse loss , memory dysfunction , and pathological accumulation of amyloid-β ( Aβ ) in plaques.
Alzheimer's disease is characterized by an upregulation of the 5-lipoxygenase ( 5LO ) , whose promoter is regulated by methylation.
Alzheimer's disease is characterized by hippocampal atrophy.
Alzheimer's disease is characterized by progressively worsening deficits in several cognitive domains , including language.
Alzheimer's disease is characterized by the deposition of intracellular aggregates of hyperphosphorylated tau protein.
Alzheimer's disease is characterized by the presence of extracellular deposits of amyloid , primarily composed of the amyloid β-protein ( Aβ ) .
Alzheimer's Disease is particularly interesting due to the wide-spread effects on cortical architecture and alterations of volume in specific brain areas associated with memory.
Alzheimer's disease is the most common form of dementia.
Alzheimer's disease is the most common form of dementia.
Alzheimer's disease is the most common form of dementia , characterized by two pathological hallmarks : amyloid-β plaques and neurofibrillary tangles.
Alzheimer's disease is the most common form of dementia diagnosed in the aging population worldwide.
Alzheimer's disease is the most common major neurocognitive disorder with substantial social and economic impacts.
Alzheimer's disease is the most common neurodegenerative disease of Western societies , suggesting the need for early diagnosis , even in preclinical stages.
Alzheimer's disease is the most frequent type of dementia , and its prevalence is rapidly increasing due to the aging of populations.
Alzheimer's disease neuropathologic changes were not associated with ever having AF but were more common in people with permanent AF.
Alzheimer's disease neuropathology ( amyloid , tauopathies ) and brain atrophy are present decades prior to manifestation of clinical symptoms.
Alzheimer's disease patients had @percent@ of normalized white matter volume with increased mean diffusivity and @percent@ of the white matter had reduced fractional anisotropy.
Alzheimer's disease , the prevailing form of dementia , is projected to quadruple worldwide.
Alzheimer's is a crippling neurodegenerative disease that largely affects aged individuals.
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AM251 is also potent at modulating tumour cell growth , suggesting that growth factor-mediated oncogenic signalling could be regulated by AM251.
AM251 promoted the degradation of ERRα protein without loss of the corresponding mRNA.
AMA CME credits were provided by Greater Baltimore Medical Center , Baltimore , MD.
A macro-shear bond-strength protocol was most frequently used ; it revealed significantly lower bond strengths and was less discriminative than the other test methods.
A main aim of this laboratory is to understand how neurons perform and survive in the constitutive stress background represented by aging.
A main component is the collection of biomeasures to objectively assess physiological status relevant to psychosocial variables , aging conditions , and disease.
A main effect of APOE genotype on hippocampal volume was observed , but only when the APOE-by-testosterone interaction was present.
A main effect of ApoE on rates of decline after age @number@ was found for verbal , spatial , and speed factors.
A main finding was that SSD differs qualitatively from syndromal depression but not clearly from nondepression.
A main objective of current medical research is to improve the life quality of elderly people as priority of the continuous increase of ageing population.
A major category of stressors that contribute to the alterations within the T lymphocyte compartment is the family of herpes viruses.
A major cause is reduction of free testosterone.
A major challenge in the treatment of elderly patients with chronically elevated blood glucose is the frequency of hypoglycemic episodes.
A major challenge that contributes to the definition of an early therapeutic window is limited technologies.
A major concern over OAB treatment of elderly patients is the risk of cognitive side effects due to the pharmacologic treatment with anticholinergic drugs.
A major contribution to the regulation of sleep stems from the circadian system.
A major contributor to intake of these nutrients is foods prepared outside the home , particularly from fast-food restaurants.
A major focus currently is on some important , still enigmatic , aspects of the ageing neuromuscular system.
A major gap in this area of research and theory development has been the lack of examination of moral reasoning in later life.
A major goal of aging research is to identify early markers of age-related cognitive decline.
A majority of breast cancer , however , will often fail to respond to endocrine therapy.
A majority of participants ( @percent@ ) thought information on screening at older ages should come from their general practitioner ( GP ) .
A majority of studies examined community-dwelling older women.
A majority of subjects treated with the dill extract also noted significant improvements in skin elasticity , firmness and slackness of the jaw line.
A majority of the 17-24-year-olds and nearly half the 25-29-year-olds viewed themselves as being adults in some ways but not others.
A majority of the respondents agreed that the definition is appropriate for clinical and research applications.
A majority of these patients exhibited overlap in measured areas of atrophy and were cognitively impaired.
A major limitation of the literature is a lack of studies assessing individual everyday activities and the associated error patterns that might occur.
A major locus contributing to this difference has been mapped to a region on mouse chromosome @number@ that contains the gene encoding PKCδ.
A major obstacle is that the new cross-linkers are either not readily available and / or have a low reactivity.
A major pillar in the effort to treat these conditions will be the shift from symptomatic treatment to disease modifying therapy.
A major problem in the field of neurodegeneration is the basis of selective vulnerability of subsets of neurons to disease.
A major problem with these equations is that they allow the physiological age to move back in time.
A malignant disorder was the cause of FUO in @number@ patients.
A mammalian 1-hybrid assay showed a functional interplay between hTERT and NF-κB p65 that may mediate NF-κB-dependent transcription activation in cells.
A managed clinical network would be the most appropriate model to ensure appropriate organisation and utilisation of scarce resources in this area.
A mandatory retirement age could be discriminatory and take many competent physicians out of practice and risk a physician shortage.
AM and PM durations were also positively correlated and remarkably stable across age groups.
A manic state in the elderly is often atypical and different from that in younger and middle aged patients.
A manipulation that distracts attention and reduces effortful processing may therefore decrease women's own-gender bias by reducing memory for female faces relative to male faces.
A Mann-Whitney U test revealed that a higher score on the Raven's Advanced Progressive Matrices was significantly associated with lower incidences of inattentional blindness.
A Mann-Whitney U test was performed to determine if severe left ventricular systolic impairment affected maintenance dose.
A map of the synergies between factors is presented that places the older person at the centre of a network of vulnerabilities.
( Amaranthaceae ) , also known as Chaff Flower and Niuxi / , mainly includes two famous medicinal species namely A. bidentata and A. aspera.
A marked effect was observed after four weeks of storage , which corroborates recent clinical data.
A marked loss of 18-MEA was observed.
A marked reduction in catalase expression and activity results in millimolar accumulation of hydrogen peroxide , contributing to bulbar melanocyte malfunction and death.
A Markov model was used to forecast NAFLD disease progression.
A master regulator of these functions is ( PI3P ) , a phospholipid synthesized primarily by class III PI 3-kinase Vps34.
A matching-to-sample psychophysical method was used to measure improvements in orientation discrimination thresholds and reaction times ( RTs ) .
A maternal vaccine under development could prevent EOGBS and LOGBS.
A maximal response in muscle protein synthesis is achieved with the consumption of 20-25 g of protein alone.
Amazingly , little is known about their cellular and regional distribution in the brain , however.
Ambient air pollution and temperature have been linked with cardiovascular morbidity and mortality.
Ambient air pollution is associated with CVD , but its effect on telomere length is unknown.
Ambient Assisted Living ( AAL ) is a growing field resulting from aging populations in the majority of the well-developed regions of the world.
Ambient PM2.5 ( particulate matter with aerodynamic diameter ≤ @number@ μm ) is an emerging determinant of glucose dysregulation.
Ambient sensors offer patients comfortable and discreet point-of-care monitoring.
Amblyopic children were the worst performers under all viewing conditions , even when using the dominant eye.
Ambulatory blood pressure monitoring ( ABPM ) is central in the management of hypertension.
Ambulatory BP patterns showed higher nocturnal BP among patients with long-lasting disease.
Ambulatory costs accounted for differences between CN and MCI.
Ambulatory monitoring was performed in @number@ normotensive ( NT : @number@ females ) and @number@ untreated hypertensive patients ( HT : @number@ females ) .
Ambulatory urodynamic techniques therefore have to be considered.
AMD affects central vision which impairs one's ability to drive , read and recognize faces.
AMD documentation on surgery was statistically more frequent ( @percent@ ) than for either medicine ( @percent@ ) or psychiatry ( @percent@ ) .
AMD documentation was compared among three inpatient services : surgery , medicine , and psychiatry.
AMD is a complex disease in which genetic , environmental and inflammatory factors influence its onset and progression.
AMD is characterised by accumulation of extracellular deposits called drusen in which Aβ is a key constituent.
AMD shares common risk factors and processes , including vascular and inflammatory pathways , with many systemic disorders.
AMD , the leading cause of irreversible blindness among the elderly , involves many genetic and environmental risk factors , including oxidative stress and inflammation.
AMDTs and FMDTs were measured at a 5-Hz rate , using a 500-Hz sinusoidal carrier.
AMD was assessed following the modified Wisconsin AMD grading protocol.
AMD was assessed from retinal photographs.
AMD was more prevalent in men ( @percent@ ) than women ( @percent@ ) ( p = @number@ ) .
A mean annual incidence of @number@ MS patients ≥ @number@ was observed.
A meaningful aging process can be constructed within the context of gender and disability.
A measure of global cognition was not associated with alcohol intake at any point over the follow-up.
A measure of knowledge about the workshop material revealed a significant increment at posttest.
A mechanistic understanding of these age-associated processes , their interrelations and environmental dependence is currently lacking.
A median @number@ 20-minute sessions were completed and no adverse events were reported.
A mediational model was used to identify the underlying mechanism of the relationship between the number of behavioral problems and poor mental health in caregivers.
A medication possession ratio ( MPR ) with a cut-off value of @percent@ was used to measure medication adherence.
A Mediterranean-type diet , with or without energy restriction , is an effective treatment component.
A Medline search was conducted , reviewing English-language publications from @number@ to @date@ .
A meeting , \ "The Yin and Yang of Inflammation \ " was organized by Trudeau Institute and was held between @date@ @number@ @number@
A meniscal tear can lead to knee OA , but knee OA can also lead to a spontaneous meniscal tear.
Amenorrhea may be viewed as a sentinel indicator of stress.
A mentoring process for therapists included feedback from peers and experts after viewing treatment videos.
A mentoring program could help the new NP further develop competencies and capabilities as a provider.
America is entering into a proverbial \ "perfect storm \ " of medication errors.
Americans are living longer than ever before in history.
Americans in Israel are one migrant group that represents the worldwide phenomenon of transnationalism.
Americans reported higher self-life satisfaction , perceived family's life satisfaction , and positive affect than did Chinese.
Ames dwarf ( Prop1 ( df / df ) ) mice are remarkably long-lived and exhibit many characteristics of delayed aging and extended healthspan.
A meta-analysis indicated a @number@ % decrease in cataract among statin users.
A meta-analysis of cross-sectional and longitudinal studies investigating fractures and BMD was conducted.
A meta-analysis of exome-wide association studies was performed across cohorts for CAC and carotid intima-media thickness.
A meta-analysis of @number@ published articles ( with @number@ independent participant groups ) was conducted to analyze the relationship between task-switching effects and aging.
A meta-analysis was first performed on the relationship between T1DM and cognitive changes in youths and adults respectively.
A meta-analysis was not performed owing to the studies ' heterogeneity in outcomes measures , methodology , and study country.
A meta-analysis was performed and effect sizes ( ES ) calculated.
A meta-analysis was performed to determine the mean difference ( MD ) in RBCV between post- and pre-ExT measurements.
A meta-analysis was performed to determine the standardized mean difference ( SMD ) in Qmax between EA and age-matched untrained healthy subjects.
A meta-analysis was performed to synthesize the available data on the proportion of positive blood cultures in septic patients and the microorganism distribution.
A meta-analysis was performed using a random effects model along with log odds ratios and the chi-square test.
A meta-analytic P-value of @number@ was found when these were combined with the CAGES consortium.
A metabolic shift leading to increased mobilization of non-carbohydrate substrates such as branched chain amino acids or long chain fatty acids was observed.
A meta-regression found only DA target as a significant moderator of the age effect.
A method for the analysis of three-dimensional statokinesigrams based on nonparametric statistics and image-processing analysis was employed.
A methodological quality assessment was conducted , and a meta-analysis computing overall odds ratios ( ORs ) was performed where possible.
A methodological study was used to test the reliability and validity of the instrument.
A methodology was developed with MALDI-MSI to map epidermis and dermis proteins.
AMH appears to be the first marker to change , followed by FSH and inhibin B. Estradiol declines in late MT.
AMH assays continue to evolve and technical issues remain ; the absence of an international standard is a key issue.
AMH can also identify ' poor responders' , but it seems inappropriate at present to withhold IVF purely on this basis.
AMH concentrations seem to be independent of the reproductive history of the patient.
AMH coupled with age for menopause prediction provides stronger information than using age alone.
AMH declines with age , and data suggest that it can provide information on menopausal age and reproductive lifespan.
AMH doesn't predict live-birth chances after IVF.
AMH is an independent predictor of time to menopause.
AMH is a testis-specific marker used for diagnosis in infants with ambiguous genitalia or bilateral cryptorchidism.
AMH is produced in growing follicles until they reach a stage when dominant follicle is detached from a cohort of antral follicles.
AMH may be useful in assessing the need for fertility preservation strategies and detecting post-chemotherapy or surgical damage to the ovarian reserve.
AMH plays a fundamental role in the regression of Müllerian ducts in male embryo.
AMH serum concentrations at reproductive age predict ANM , but precision is currently limited.
AMH serves as a biochemical marker of the presence of testes in cryptorchidic males.
AMH shows limited short-term variability , but the influence of states such as prolonged oral contraceptive use need to be considered in clinical assessment.
AMH was measured by commercial enzyme-linked immunosorbent assay.
A micro-costing approach combined with an online expert survey was applied to simulate a decision-making scenario taking place in Germany.
A microglial cell is a double-edged sword , which has both pro-inflammatory and anti-inflammatory functions.
A microneedle fractional radiofrequency ( MFR ) device was recently developed and is a novel and promising tool.
A micronutrient powder containing @number@ vitamins and @number@ minerals was added to tomato soup and oatmeal at different levels.
A microprocessor computes the subject's MPOD , in addition to the lens OD , and uses the latter to correct the MPOD.
A microscopy study was undertaken to observe morphological changes of HepG2 cells after treatment and cell cycle arrest and apoptosis were studied using flow cytometry.
A microvascular mouse explant model that is robust , quantitative and can be reproduced without difficulty would overcome these limitations.
A mid-face lift is nevertheless mandatory to achieve an efficient skin removal on the mid-pupilla line.
Amid growing concern about the graying population , an emerging theme in public health discourse is that of \ "successful aging. \ "
Amid trends toward aging populations in developed nations , the number of people requiring nursing care has increased markedly.
A mild reduction in mitochondrial respiration extends the life span of many species , including C. elegans.
AMI mortality increased @number@.6-fold from @number@ to @number@
A Mini-Mental State Examination score of < 24 was used to define impaired cognitive function.
A minimum level of activity likely to improve sleep outcomes among older people has not previously been explored.
A minimum of @number@ subjects in each group will be enrolled , for a total of @number@ participants.
Amino acid deficiency , including L-carnitine , has been proposed to be associated with its pathophysiology.
Amino acids and biogenic amines generally improved with nutritional rehabilitation , but most sphingomyelins and phosphatidylcholines did not.
Amino acids are potent modulators of protein turnover and skeletal muscle cells are highly sensitive to changes in amino acid availability.
Amino acids such as histidine , methionine and valine correlated with pulse wave velocity.
Amino acid transporters and mammalian target of rapamycin complex @number@ ( mTORC1 ) signaling are important contributors to muscle protein anabolism.
Aminoguanidine significantly reversed the changes in alginate beads induced by IL-1β treatment.
Aminolevulinic acid ( ALA , Levulan , Kerastick Dusa USA ) was applied one hour prior to light exposure.
A minor further increase in variability explained was gained by adding chronic diseases and depressive symptoms to the model.
A minority of patients had difficulties using the aids.
A minority of PD patients had abnormal cue-information memory or difficulty in understanding the task.
A minority of subjects ( @percent@ in MMAS and @percent@ in MALES ) reported use of PDE5i.
A minor reduction in daily physical activity for two weeks increased blood lipids in both young and older men.
A minor salivary gland biopsy also has a higher accuracy for diagnosis in the elderly.
Aminosugars produced in the hexosamine pathway ( HP ) are utilized in protein glycosylation reactions involved in protein maturation and cellular signaling.
Amiodarone , which has been used since @number@ as an antiarrhythmic drug , gives rise to a variety of cardiac and extracardiac adverse side-effects.
A missense mutation has recently been reported within CHCHD2 , a gene newly associated with autosomal dominant PD.
A mitochondrial outer membrane protein NIX interacted with Mieap in a ROS-dependent manner via the BH3 domain of NIX and the coiled-coil domain of Mieap.
Am I too fat ?
Amitriptyline , nortriptyline , oxybutynin and paroxetine are medicines considered to have significant anticholinergic potency.
Amitriptyline was also significantly effective in IM compared intragroup to its own baseline ; however , placebo was equally effective in the same analysis.
A mixed effect linear regression model was used to assess the association between ACB and MMSE score.
A mixed-effect model and penalized regression spline were used to estimate the associations among phthalate metabolites , MDA , and IR.
A mixed effects model compared SOPT training effects longitudinally across five years relative to controls.
A mixed effects model framework was used to determine the degree to which DTI changes differed in PD relative to changes in healthy subjects.
A mixed-effects multivariate logistic regression model was used to analyze the association between DSD and outcome , after adjusting for relevant covariates.
A mixed linear model was used to investigate the association of ABP with log-transformed CYP17A1 activities exploring effect modification by urinary sodium excretion.
A mixed-method approach was used.
A mixed-method design was used wherein both quantitative and simple structured qualitative data were collected.
A mixed methods analysis included both quantitative and qualitative procedures.
A mixed methods approach involved a postal survey , focus group and telephone interviews.
A mixed-methods process evaluation will run alongside the RCT.
A mixed-model analysis of variance ( ANOVA ; age by walking condition ) with repeated measures was applied.
A mixed-models approach was used to examine the additive effect of age on disability for individuals with SCI.
A mix-factor ANOVA ( age-group x HTcoupling x speed ) was performed separately for the Near and FarDVA.
A mixture model was used , with nonresponders accounting for @percent@ of the patients.
A mixture of practice experience together with findings from the literature , this article explores social work practice with older people in hospital settings.
( Am J Addict @number@ ; 24 : 178-184 ) .
( Am J Addict @number@ ; 26 : 129-135 ) .
( Am J Epidemiol.
Am J Phys Med Rehabil.
AMLR differences in older adults may be due to age-related neurochemical changes in the central nervous system.
Amnestic MCI ( aMCI ) was defined by a composite episodic memory ( EM ) Z-score of < -1.5.
Amnestic mild cognitive impairment ( aMCI ) often is an early stage of Alzheimer's disease ( AD ) .
Amnestic multiple domain and nonamnestic single domain were the most common MCI types , accounting for @percent@ and @percent@ of cases , respectively.
AM occurrence was positively correlated with PM occurrence , most strongly among younger individuals.
A model animal showing spontaneous onset is a useful tool for investigating the mechanism of disease.
A model-based cluster analysis was conducted on baseline data of @number@ patients of a Dutch cohort ( PROPARK ) .
A model based on these research findings is discussed.
A model based upon the Granger causality approach was developed to investigate the cause-effect relationship over time between these regions based on GM concentration.
A model emphasizing this approach is provided as adidactic for nurses and other health professionals providing care to their older patients.
A \ "modeling drift \ " bone apposition / resorption pattern appeared only when periosteal loads were included.
A modeling simulation provided good fits to these data and offers a mechanistic explanation based on an age-related reduction of working memory.
A modeling system is introduced that provides a common language to define the various anatomic points of the full range of hairlines.
A model of accelerated aging has been proposed as a potential explanation to these epidemiological findings.
A model of dofetilide , a class III antiarrhythmic drug , was developed and included into a ventricular cell models.
A model of just age and number of hospitalizations achieved a c-statistic of @number@
A model that decomposed the manifest health indicators to valid health , systematic error , and random error was found to fit the data best.
A model that included a genetic risk score better determined the recommended starting age for screening in subjects with and without family histories of CRC.
A model useful for sustained implementation was proposed and discussed , and is hoped to facilitate future research.
A model was developed using a @percent@ random sample from HALS and tested in the other @percent@ and in ELSA.
A model with normally distributed random effects was then chosen as the robust null model.
A moderate correlation between amplitude ratios of the TA-contribution and postural sway was observed for seniors during SLEO ( r = @number@ ) .
A moderate correlation ( r2 = 0.36 , p < 0.05 ) between insulin infusion dose and phosphorylated Akt was demonstrated.
A moderate negative correlation that was significant at most conditions was observed between the full-width at half-maximum values and intelligibility scores.
A moderate positive correlation was found between age and anterior inclinations on the left and right sides.
A moderate probability of repetitive movements was associated with functional limitations in former workers.
A moderate UPR functions as a pro-survival signal to return the cell to its state of homeostasis.
A modest amount of alcohol may minimize the association between anxiety / worry and insomnia among this group.
A modest association between tibia lead and lower MMSE score was seen among participants with the GSTM1 deletion polymorphism.
A modestly more active lifestyle may nonetheless be beneficial.
A modified Bruce treadmill protocol was used to assess aerobic capacity ( VO2peak ) and time to peak exhaustion.
A modified equation for evaluating the renal function of Japanese older patients might be needed.
A modified grading system based on the well-accepted Meller and Tseng's system was used.
A modified overnight dexamethasone suppression test ( @number@ mg ) was performed as an index of GC sensitivity.
A modified Parzen Rosenblatt kernel density estimation method was used to compute the continuous resolution-agnostic probabilistic pulsatility model.
A modified power function provided an excellent fit for the data for monkeys and children.
A modified quick-release paradigm was used to estimate digit apparent stiffness , damping , and inertial parameters.
A modified version of the Remission in Schizophrenia Working Group criteria was used for determining remission status.
A molecular signature comprising three metabolites was identified , which was predictive of progression to AD in the follow-up.
Among ACS patients , cumulative ACS-related mortalities was similar between men and women ( log rank χ2 = 0.063 , P = 0.802 ) .
Among adaptation attitudes we can differentiate : constructive , dependence , hostile towards others and towards self attitudes.
Among adolescents and adults , FeNO levels were higher for males than for females , controlling for all other factors.
Among adults aged @number@ and older , the nonresponse rate on sexual orientation is lower than income.
Among aging employees , sleep problems are prevalent , but they may have serious consequences that are poorly understood.
Among all age groups , both sexes , and all ethnicities , intakes of lutein were greater than of zeaxanthin.
Among all fitness capacities , upper body flexibility showed the closest relationship with UI.
Among all nanoparticles and micelles , CTAB-containing nanosystems showed the greatest inflammatory responses.
Among all patients , @percent@ of male and @percent@ of female patients had palmar fibromatosis.
Among all patients receiving anticoagulation , the rate of recurrent events was @number@ times higher than the rate of ICH.
Among all , the homeostasis model assessment ( HOMA ) of IR ranged from @number@ to @number@
Among Alzheimer's disease patients , this asymmetry might be less dependent on the APOE genotype and a more general marker of incipient disease pathology.
Among a total of @number@ male residents , residents with obstructive measures were excluded and final study population was composed of @number@ residents.
Among Aβ-specific genes were those involved in aging , proteasome function , and mitochondrial function.
Among bankers , @percent@ would recommend the treatment to others.
Among Berlin questionnaire categories , snoring correctly classified @percent@ of the sample and explained the @percent@ variance of AHI.
Among Black non-Hispanics , the difference for any BCCP user was @number@ % points and for regular users , @number@ % points.
Among blood test data , the decrease in BAP had the strongest correlation with the ALP decrease.
Among blue-collar men , the corresponding rates were @number@ @number@ and @number@
Among brain lipids , alteration in the ω-3 polyunsaturated fatty acid docosahexaenoic acid ( DHA ) homeostasis is implicated in AD pathogenesis.
Among brain regions , the number of abnormalities in cerebellum decreased while the number in cortex greatly increased with age.
Among cancers , lung cancer is the leading cause of cancer in the Western world.
Among cancer survivors , ORT correlate with amenorrhea.
Among cardiovascular risk factors , dyslipidemia is certainly the most persistent and highly prevalent.
Among Chinese subjects CMBs were , independent of other concomitant markers of cerebral small vessel disease , associated with poorer cognitive function.
Among CKD patients with heterogeneous etiologies , however , there was an unadjusted lower risk ( p < @number@ ) .
Among cognitive measures , working memory and visuospatial abilities showed the strongest interrelationship to spectral-pattern discrimination performance.
Among comorbid conditions , none were significantly associated with rhinitis.
Among CPCs , CD34 + cells ( CD34 + CPCs ) seem to predict outcome in CV disease , also in elderly people.
Among CpG loci with high variability between participants , more than @percent@ had ICC > @number@
Among cyclin E interactors we identified several novel tissue-specific substrates of cyclin E-Cdk2 kinase.
Among debtors , high-income parents had more debt than low-income parents.
Among dentate participants , the differences between the two groups were small and statistically significant differences were seen mostly in women.
Among dentate persons , 24·4 % had an inadequate dentition with 10·3 % defined as ' chewing deficient'.
Among different groups , the inpatient reimbursement rate ranged from @percent@ to @percent@ , and the outpatient reimbursement rate was between @percent@ and @percent@.
Among different putative functions , the non-pathogenic protein isoform PrP ( C ) is involved in several cellular processes.
Among DM patients , the CART analysis identified subgroups with higher FRAX scores.
Among DM , the tree-based regression ( classification and regression tree ( CART ) ) analysis identified groups of patients with different mean FRAX scores.
Among each specific Fried's criteria , ' slowness ' had the strongest association with a low QoL score.
Among edentulous respondents , females and those with no formal education reported significantly lower quality of life.
Among elderly population , male gender seems to be highly correlated with the risk and aggressiveness of thyroid cancer.
Among females , but not males , rural residence and poor social network were risk factors for incident MDD.
Among females , the decline was from @number@ ( @number@ ) to @number@ ( @number@ ) .
Among Firmicutes , Clostridiales was dominant in aged pit mud while Bacillales and Lactobacillales were dominant in aging pit mud.
Among former and current smokers , all effects were statistically non-significant.
Among FTC / TDF users , we compared protease inhibitor ( PI ) versus NNRTI users and lopinavir / r versus efavirenz users.
Among genes implicated by the top DMRs were protocadherins , homeobox genes , MAPKs and ryanodine receptors.
Among healthy controls , similar analyses revealed increased age-related cortical thinning in the left occipital lobe among smokers compared with nonsmokers.
Among healthy older adults , lower receptor binding may be associated with slower processing speed.
Among hip surgery patients , the most common causes of death were circulatory diseases , followed by dementia and Alzheimer's disease.
Among H. pylori-infected patients , those who receive long-term treatment with proton pump inhibitors more frequently develop preneoplastic lesions.
Among humans , age-related decline in testosterone is associated with declining cognitive functioning , and aging men with higher testosterone maintain better cognitive performance.
Among individual brain regions , the temporal cortex was found to be most predictive for MRI and PIB-PET.
Among individuals aged @number@ years , CRP and periodontal status were weakly but significantly associated with MoCA-J score.
Among individuals , biological aging leads to cellular and organismal dysfunction and an increased risk of chronic degenerative diseases and disability.
Among individuals @number@ years or older , no relationships between sleep duration and mortality were observed.
Among individuals who were cognitively intact before death , autopsies may reveal some Alzheimer's disease-type pathology.
Among individuals with diabetes , long-term treatment with metformin may reduce the risk of cognitive decline.
Among KT recipients , the severity of VC increased with the length of time after transplantation and became more substantial after @number@ years.
Among longevity Chinese , there is no association between BMI and sleep quality.
Among long-term care residents , self-care disability lowers quality of life and increases health care costs.
Among males , estimated survival probability declined from @number@ ( @number@ ) to @number@ ( @number@ ) .
Among males , only smoking history and white race were associated with an increased prevalence of fracture ( P < @number@ ) .
Among male subjects , the presence of malnutrition was associated with FI and thus presented a high relative risk index for its occurrence.
Among many factor that influence quality of aging has obesity , where in Croatia the prevalence of obesity is greater in older women than men.
Among members of this family , SIRT6 appears to have particular significance in regulating metabolism , DNA repair and lifespan.
Among men aged 70-74 at baseline , prevalence of frailty was @percent@ , but at 5-year follow-up the prevalence was @percent@.
Among men also systolic blood pressure and low education predicted multimorbidity.
Among men , a synergistic interaction between low vitamin C and genetic risk was found.
Among men , baseline age was associated with change in Peak Y ( tm ) , but in a nonlinear pattern.
Among men , diabetes duration is longest , followed by COPD.
Among men it was level of sexual desire ( @number@ % ) and erectile difficulties ( @number@ % ) .
Among men , never smokers had significantly higher scores , such as in the Symbol Digit Substitution Test.
Among men , @percent@ reported having functional limitations , compared to @percent@ among women.
Among men , susceptibilities toward many infectious diseases and the corresponding mortality rates are higher.
Among men the group experiencing decreasing loneliness had the highest OR of good health.
Among men , the relative risk was @number@
Among men who had one or more FP + visits , @percent@ of HIV + and @percent@ of HIV- men had less than two comorbidities.
Among men who were tested , @percent@ did not meet Endocrine Society guidelines for low testosterone.
Among men with DM at baseline , high blood pressure , physical inactivity , and smoking increased the likelihood of incident multimorbidity.
Among Mexican-Americans , an increase of one standard deviation in LTL was associated with a @number@ year earlier menopause.
Among MMC enrollees , better health and more positive MMC processes related to higher HSA and lower unmet needs.
Among modifiable factors , low physical activity and protein intakes are the best contributors to sarcopenia and the loss of strength in postmenopausal women.
Among MPS , bradykinesia but not rigidity or tremor was associated with worse quantitative gait performance in older adults.
Among multiple causative factors , evidence suggests that cognitive impairment in older subjects may be influenced by diet.
Among multiple hypotheses which have been proposed in the pathogenesis of vitiligo , autoimmunity and oxidative stress-mediated toxicity in melanocytes remain most widely accepted.
Among nonagenarians , @percent@ had severe disability and impaired functioning while @percent@ had multimorbidity and slow gait speed.
Among noncancer patients , renal failure ( @percent@ ) was the most common diagnosis.
Among non-First Nations people , men had a higher lifetime risk of diabetes than women across all index ages.
Among non-participants , vision and spinal problems prevailed.
Among non-poor , high-to-moderate , steeply-increasing , and stable-low groups were found.
Among nonsmokers , @number@ were smokers in @number@
Among non-smokers , @percent@ showed positive and @percent@ showed negative hTERT expression in the dermis.
Among non-smokers , there was no difference in pregnancy rate by passive or partner smoking.
Among non-smokers with high physical fitness , @percent@ reached the age of @number@ years , compared to @percent@ among non-smokers with low physical fitness.
Among non-survivors , age effects were minimal.
Among NT , aged group displayed an increment of collagen fibers versus young group.
Among @number@ class III obesity participants , mortality rates were @number@ in men and @number@ in women during the study period ( 1976-2009 ) .
Among @number@ deaths , @number@ ( @percent@ ) occurred within @number@ weeks after release from prison.
Among @number@ endometrial cancer survivors in Germany and @number@ in Sweden , overall @number@ and @number@ SPCs were recorded , respectively.
Among @number@ LTCI users in Niigata City , there were @number@ dialysis patients.
Among @number@ non-frail participants , @number@ became frail over @number@ years.
Among @number@ normal-weight participants , rates were @number@ and @number@ in men and women , respectively.
Among @number@ normotensive men at baseline , @number@ ( @percent@ ) developed hypertension during the mean @number@ years of follow-up.
Among @number@ @number@ participants at risk , @number@ new cases of measured hypertension occurred.
Among @number@ @number@ participants free of self-reported hypertension at baseline , @number@ ( @percent@ ) incident cases occurred within 5-9 years of follow-up.
Among @number@ participants free of depression at the 1-year follow-up , the cumulative incidence of depression was @percent@.
Among @number@ participants free of diabetes at baseline , @number@ subjects developed diabetes during an average @number@ years of follow-up.
Among @number@ participants initially free from diabetes , @number@ ( @percent@ ) were diagnosed with diabetes during ∼4 years follow-up.
Among @number@ participants over @number@ years , @number@ incident CHF events occurred.
Among @number@ participants with ACR data , @percent@ ( n = @number@ ) had elevated ACR.
Among @number@ patients aged @number@.4±7.4 years , OH was found in @number@ subjects ( @percent@ of cases ) .
Among @number@ patients hospitalized for COPD , @number@ ( @percent@ ) used LABDs±ICSs during the specified period.
Among @number@ patients meeting study criteria , we identified @number@ statin users and @number@ nonusers.
Among @number@ patients , @number@ began HAART.
Among @number@ patients , @number@ patients ( @number@ men ) were elderly ( age ≥ @number@ years ) .
Among @number@ patients on Levodopa , @number@ had normal scans and Levodopa was stopped.
Among @number@ patients , Study of Osteoporotic Fractures testing found @percent@ to be robust , @percent@ prefrail , and @percent@ frail.
Among @number@ patients treated as protocol violations , @number@ presented with a lack of recanalization and a parenchymal hematoma type @number@
Among @number@ stones , @number@ ( @percent@ ) affected men.
Among @number@ subjects , @number@ had any CMBs ( @percent@ ) , of whom @number@ ( @percent@ ) had multiple CMBs.
Among @number@ subjects who were normal at baseline , @number@ acquired MCI and @number@ remained normal.
Among octogenarians , ICU survivors got less mechanical ventilation or renal replacement therapy than nonsurvivors.
Among octogenarians mortality was similar despite the operation.
Among older adults , 12-min walk , timed up and go , hand grip and quadriceps strength were determined.
Among older adults , as age increased , accuracy decreased and rate of response change increased.
Among older adults , everyday competence is often expressed in the context of other participating individuals.
Among older adults , perceived age discrimination is highly associated with unhealthy outcomes and dissatisfaction.
Among older males , there was evidence that the hyoid bone in the aspirators tended to be positioned more posterior compared to the nonaspirators.
Among older people , genes exhibiting DNA methylation decreases were part of a microRNA-regulated gene network functioning to suppress cancer.
Among older people , the neutral association harmed performance ; the emotional fact mitigated performance back to baseline.
Among older person households , those without offspring or grandchildren and skip-generation households fare worst in most countries.
Among older populations the proportion of time spent in less than full health tends to increase.
Among other advantages of skin is a broad repertoire of available genetic tools enabling the creation of cell type-specific circadian mutants.
Among other factors , genetics and certain foods are proposed to contribute.
Among other factors , research studies have linked certain medications with an increased risk of falls.
Among others , a major factor that has been implicated in the initiation of aging is the physiologic decline of hormones occurring with age.
Among others , analyses of variance were used to test the differences between groups with distinct experiences of unemployment periods.
Among others , telomerase and telomere damage is one of the intrinsic physical instigators that drive agerelated degenerative changes.
Among other things , the study revealed that Greek identity and cultural customs are often significant to first generation GIs.
Among other things , this finding affects the assessment of the speed at which countries will age.
Among our sample of mean age @number@ years , the one-week prevalence of clinically significant depressive symptoms was @percent@.
Among parous women , the relationship between parity and longevity was significant among White but not Black women.
Among participants < 50 years , the contribution of increases in systolic blood pressure or antihypertensive medication initiation was similar to aging.
Among participants < 80 years of age , frailty and interleukin-6 were also associated with shorter survival.
Among participants in the USA , age correlated negatively with endorsement of a medical model of depression ( p = < 0.001 ) .
Among participants , @percent@ agreed to comprehensive medical evaluation , @percent@ limited local evaluation , and @percent@ survey only.
Among participants , @percent@ and @percent@ had low serum BT levels and a positive ADAM questionnaire , respectively.
Among participants who did not perceive dry skin , @percent@ showed low stratum corneum hydration.
Among participants who died between 2005-2012 ( n = @number@ ) , additional analyses identified clinical and pathological features associated with HS-Aging pathology.
Among participants with accelerometer data , these associations were generally mediated by higher levels of moderate / vigorous PA.
Among participants with an eGFR ( cys ) < 45 ml / min per @number@ m ( @number@ ) , @percent@ had prevalent frailty.
Among participants with diabetes , worse cognitive performance was associated with metformin use ( @number@ [ @number@ @date@ ] ) .
Among participants with no depression symptoms at baseline , results suggest that depressive symptoms may increase with aging regardless of incipient dementia.
Among patients aged 45-64 years , fatality decreased from @percent@ in @number@ to @percent@ in @number@ ( P < @number@ ) .
Among patients aged 65-84 years , fatality decreased from @percent@ in @number@ to @percent@ in @number@ ( P < @number@ ) .
Among patients aged ≥85 years , fatality decreased from @percent@ in @number@ to @percent@ in @number@ ( P < @number@ ) .
Among patients diagnosed with alcohol dependence disorder typical of taking psychoactive substances such as liver , pancreas , gastrointestinal tract.
Among patients in the intervention group , there was less risk of depression and dyspnea.
Among patients , maps of thickness along the whole cortical surface revealed reduced insular thickness but no effects in other regions.
Among patients over @number@ years old , @number@ ( @percent@ ) died before being discharged.
Among patients who underwent screening colonoscopies , we calculated the percentage of those with life expectancies < 10 years.
Among patients with AD and MCI , one third of them showed \ "saving appearance behavior \ ".
Among patients with AKI and asymptomatic hematuria or proteinuria , different diagnoses were found with high levels of advanced chronic nephropathy.
Among patients with calcification , a more severe degree was observed in KT recipients ( P = @number@ ) .
Among patients with CF , greater AWP occurs in those who are homozygous for the DeltaF508 mutation.
Among patients with epilepsy , 27 ( @percent@ ) became seizure-free at a median age of 10years and @number@ remained seizure-free even after antiepileptic withdrawal.
Among patients without a diagnosed disorder of hypogonadism , the use of opioids and obesity were the strongest predictors of testosterone prescription.
Among PCa patients , antibodies against HPV @number@ were associated with a higher Gleason score ( p = @number@ ) .
Among people feeling lonely , those with depression were more frequently married and had a small social network.
Among people over @number@ years old , increase in stroke incidence , high mortality rates and adverse outcomes are problems of major public concern.
Among people with depression , @percent@ were at nutritional risk , compared with @percent@ of people without depression.
Among people with diabetes , those with other conditions were much less likely to have no disability in the final year of life.
Among persons who are obese , an age-adjusted @percent@ of women and @percent@ of men reported doctor-diagnosed arthritis.
Among persons with arthritis , the association between 6MWD and EQ-5D-5L was slightly stronger.
Among platelet transcripts , MRP-14 has emerged as a powerful predictor of ACS.
Among polymorphisms , C677T , a thermolabile form , but not A1298C , thermostable , was associated with fatty liver and insulin resistance.
Among potential alternate models of neurodegeneration , mouse prion disease outperformed all other disease-specific models.
Among prior studies , differences in study design have contributed to the study-to-study variability in reported disease prevalence.
Among products where melatonin has been identified include wine , olive oil , tomato , beer , and others.
Among realists , increasingly positive SH predicted survival.
Among rowers ' main causes of death , cardiovascular diseases are reduced in relation to their compatriots.
Among separate aspects of global sleep quality , low perceived sleep quality and decrements in daytime function were most related to shorter telomeres.
Among serum sex steroids , DHEA-S was the most correlated parameter with autonomic functions.
Among seven geographic areas , Hokkaido showed the lowest prevalence ( @percent@ ) , while Yamagata Prefecture represented the highest ( @percent@ ) .
Among several factors , oxidative stress is a major player in the etiology of skeletal muscle dysfunction associated with those conditions.
Among several modifications of forkhead box O factors , we focus on reversible acetylation , describing past research and current advances.
Among several theories , oxidative stress / free radical theory offers the best mechanistic elucidation of the aging process and other age -related phenomenon.
Among SGAs , clozapine and olanzapine had great liability to induce weight gain and metabolic adverse reactions.
Among SGLT1 , SGLT2 , glucose transporter ( GLUT ) @number@ and GLUT2 , we found a significant decrease only in the level of SGLT2.
Among singles , economic well-being varies by marital biography and gender.
Among smokers , an inverse relationship manifested between vitamin D3 and plasma AGE-associated fluorescence as well as soluble vascular adhesion protein-1.
Among smokers , @percent@ showed positive and @percent@ showed negative hTERT expression in the dermis.
Among specific diseases , LBP by disc herniation or degeneration was shown to be substantially associated with the loss of LLC.
Among stage I and II patients , statin use was associated with better recurrence-free but not with better CRC-specific survival.
Amongst boys , sons of degree-educated women had lower BMI but there was little difference between the lower maternal education categories.
Amongst girls there was a clear gradient across all categories of maternal education by age @number@ with daughters of more educated women being less adipose.
Amongst healthy older adults , more managerial or supervisory experiences in midlife are linked to a slower hippocampal atrophy rate in late life.
Amongst @number@ donors with PDFOR , @number@ ( @percent@ ) presented with at least one low ( CGGn < @number@ ) allele.
Amongst the immune components most affected by aging are T lymphocytes.
Amongst them , preventive surgical intervention needs to be considered.
Amongst the sample , @percent@ ( n = @number@ ) lived in their own homes and @percent@ ( n = @number@ ) lived alone.
Amongst these are Bloom's syndrome ( BS ) and Fanconi anaemia ( FA ) .
Amongst these is the possible influence of age-related perturbations of sex hormones , particularly , the fall in testosterone in ageing men.
Amongst these , models where rodents are exposed to d-galactose are held to recapitulate a number of features of ageing including neurobehavioral and neurochemical changes.
Among subjects not on anti-hypertensive medications , plasma ALP , ALT and GGT were related to blood pressure ( P < 0.01 ) .
Among such spaces , semi-basements hold a particular relevance because of their specific characteristics and their effects on human health.
Among survivors ( ~20% of the sample ) , TTD is unknown , producing a missing-data problem.
Among the AMPA potentiators , S @number@ is emerging as a new selective positive allosteric modulator of AMPA-type glutamate receptors.
Among the antiplatelet agents , highly purified eicosapentaenoic acid ( EPA ) in fish oil has the effect of lowering CAVI.
Among the associated diseases , the cholelithic disease , urolithiasis and chronic bronchitis prevailed , especially with recurrent myocardial infarction.
Among the autopsy subset , the odds of an AD pathologic diagnosis were compared in the @number@ subgroups.
Among the autopsy subset , the odds of having an AD pathologic diagnosis did not differ between the dysexecutive and amnestic subgroups.
Among the best sources are certain culinary seasonings , all of which are ingredients used extensively in the French kitchen.
Among the blind , @percent@ was caused by cataract , and the low vision caused by cataract was @percent@.
Among the brain banks , the Brain Bank for Aging Research and Fukushimura Brain Bank were reported in detail in different chapters of this issue.
Among the cluster , ANRIL expression showed the strongest association with the multiple phenotypes linked to the 9p21.3 region.
Among the complex determinants of aging , mitochondrial dysfunction has been in the spotlight for a long time.
Among the cuticular descriptors , surface roughness increased significantly with age.
Among the CVD , systemic arterial hypertension ( SAH ) is related to more than half of those outcomes.
Among the detected genes , poplar bud extract significantly regulated genes involved in antioxidant defenses , inflammatory response and cell renewal.
Among the detergent-insoluble proteins identified in amygdala of demented subjects but not controls were Tau , TDP-43 , Aβ , α-synuclein , and ApoE.
Among the different types of symptoms , only abusive behaviors were less likely to be associated with DSI.
Among the elderly , the 30-day mortality was @percent@ in medical , @percent@ in acute surgical , and @percent@ in elective surgical ICU patients.
Among the elderly , the quality of higher brain function is a contributing factor in performing activities of daily living.
Among the eldest ( age ≥85 years ) , concomitant drug use was stable over NSAID groups.
Among the endogenous antioxidants , selenoproteins play a key role in antioxidant defense and in maintaining a reduced cellular environment.
Among the environmental effects , nutrition , hygiene and weather conditions play a role.
Among the examined psychosocial characteristics , greater depressive symptoms were associated with greater relative risk of experiencing single and multiple fall events.
Among the few studies of cognitive stimulation in elderly , surprisingly there is no enough research comparing direct and indirect active stimulation programs.
Among the first @number@ potentially eligible survivors selected for recruitment , @number@ were subsequently confirmed to fulfill eligibility criteria.
Among the FoxO isoforms , FoxO1 is a main target of insulin signaling and regulates metabolic homeostasis and organismal survival at many different levels.
Among the frail , @percent@ were hospitalized in the previous year , compared to @percent@ of the prefrail and @percent@ of persons considered robust.
Among the frailty criteria , the sedentary behavior was the one most affected by the intervention.
Among the genes affected , granulocyte colony-stimulating factor receptor , Runx1 , and protein tyrosine phosphatase receptor c were included.
Among the genetic mechanisms , those attributed to Sirtuins ( @number@ orthologs identified in the human genome ) are especially important.
Among the growing CPLs , initial cyst size was associated with future lesion growth to and beyond @number@ cm.
Among the GSS-associated mutations , P102L is the most commonly reported and was also the most common at UCSF.
Among the HIV + group , higher UPSA-B scores were related to better neuropsychological ability , but unrelated to self-reported functional independence.
Among the identified risk factors of age-related macular degeneration , sunlight is known to induce cumulative damage to the retina.
Among the individuals with both PLEs and SAMD , @percent@ did not seek any help ( poor-help-seeking status ) .
Among the intrinsic causes , vascularization recently gained a major role.
Among the isolated compounds , ergosterol peroxide ( @number@ ) reduced senescence associated β-galactosidase ( SA-β-gal ) activity increased in HUVECs treated with adriamycin.
Among the last ones stress plays the essential role.
Among the least-endorsed criteria were the traditional transition events of entering marriage and parenthood , as well as \ "avoid becoming drunk. \ "
Among the logistic , the Gompertz , and the hyperbolic function , the exponential function described the data best.
Among them , 1H7 and 5C1 were most effective at decreasing levels of CT-α-syn and higher-molecular-weight aggregates.
Among the major advantages of using the fly is its small genome , which can also be modified very easily.
Among the major consequences are increased collagen degradation and reduced collagen synthesis.
Among them , ankle mean arterial pressure was the strongest correlate of carotid augmentation index ( r = 0.51 , P < 0.0001 ) .
Among the many purposes ART can be used for , this contribution focuses on the development of personal assistant devices for an aging society.
Among them are vascular , lifestyle and psychological risk factors that may act both independently and by potentiating each other.
Among the married , cultural preferences explain a greater proportion of the variation in living arrangements ; among the non-married , economic constraints do.
Among the master athletes , power-trained athletes had a larger ( P < 0·001 ) muscle mass than endurance-trained athletes.
Among the MCI subjects , @number@ progressed to AD in the follow-up.
Among the mechanisms that control the maintenance of satellite cells properties , the Notch pathway plays a crucial role.
Among them , eight proteins were identified unambiguously.
Among the metabolic syndrome components , only blood pressure uniquely predicted all four cognitive domains.
Among them , four miRNAs were validated by quantitative RT-PCR.
Among them , functional impairment explains the major part of the association between diabetes and nursing home admission and leads to increasing costs.
Among them , glioblastomas are malignant and largely resistant to available treatments.
Among them , homoplasmic G6709A ( MT-CO1 ) and G14804A ( MT-CYB ) alterations cause amino acid changes in the highly conserved residues.
Among them hypertension and diabetes mellitus are frequent findings , which will probably cause an increased incidence of dementia.
Among them , insulin / IGF-1 plays a key and evolutionary conserved role.
Among them , Insulin-like Growth Factor I and Glial cell line-Derived Neurotrophic Factor are emerging as powerful neuroprotective molecules.
Among the miRNAs regulated by CCL5 , miR-199a was the most downregulated miRNA after CCL5 treatment.
Among them is a vast family of long ( > 200 nt ) noncoding ( lnc ) RNAs.
Among the misdiagnosed , @time@ % were treated with potentially inappropriate medication.
Among them , it seems that physical activity and nutrition have some beneficial effects.
Among them , M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions.
Among them , miR-200c expression substantially was down-regulated.
Among them , nucleoside analogue @date@ belonging to the ribose series was found to be @number@ to 66-fold more active than AICAR.
Among them , @number@ individuals were treated for dementia.
Among them , @number@ initially non-frail participants were re-examined @number@ years later.
Among them , @number@ patients had more than one cardiovascular disease.
Among them , @number@ patients had undergone spot-therapies.
Among them , @number@ ( @percent@ ) were unemployed , and @number@ ( @percent@ ) had no health insurance.
Among them , @number@ underwent the protocol twice to assess repeatability.
Among them , @number@ were assessed with sarcopenia ( @percent@ ) and @number@ ( @percent@ ) with osteoporosis.
Among the most severe problems during aging are bone loss-associated diseases such as poor fracture healing and osteoporosis.
Among them , phenolic acids emerge with a very interesting potential.
Among them , postmortem biochemistry is important to investigate the systemic pathophysiological changes involved in the dying process that cannot be detected by morphology.
Among them , PPARα regulates lipid and glucose metabolism and skin homeostasis.
Among them , social activities and performing-arts activities have the most relevance to subjective well-being.
Among them , the continuous elevation of plasma BNP due to VHD might be one of the explicable factors suppressing the progression of CAD.
Among them , the domain containing @number@ ( CHCHD10 ) has been reported to play a controversial role in ALS.
Among them , the mean age was @number@ ± @number@ years and @number@ ( @percent@ ) of them were women.
Among them , the merger of the heart and large blood vessel disease would be expected to be directly linked to the perioperative management.
Among them , the most common one is that directed against factor VIII ( FVIII ) .
Among them the networks , inextricably affect normal ageing by maintaining or restoring protein homeostasis to preserve proper cellular and organismal function.
Among them , the production and secretion of adiponectin is inversely correlated to the severity of obesity.
Among them , the strategy with the greatest mortality ( which implies the greatest instantaneous growth rate ) is selected.
Among them , those featuring a five-membered ring nucleobase are of utmost interest such as the anti-cancer agent AICAR or the anti-viral drug ribavirin.
Among them , WC and HC exhibited the highest correlations in female ( @number@.38-0.42 ) and in male ( @number@.36-0.37 ) , respectively.
Among the non-prophylactic group , aging and hypoalbuminemia were statistically significantly associated with incidence of invasive fungal infections.
Among the normal weight children , @percent@ migrated to underweight , @percent@ migrated to overweight and @percent@ migrated to obesity.
Among the Nrf2 downstream genes , glutamylcysteinyl ligase and glutathione peroxidase-2 were induced at the mRNA and protein levels.
Among the @number@ adults with late-onset seizures and dementia who died , mean survival after seizure onset was @number@ years.
Among the @number@ cases ( including ours ) published in the literature , most patients had cervical spondylosis and were senior men.
Among the @number@ CpG sites associated with ageing , methylation level of @number@ sites was also associated with gene expression levels.
Among the @number@ French cyclists who participated at least once between @number@ and @number@ @number@ ( @percent@ ) died by @date@ .
Among the @number@ good quality studies , @number@ reported positive impact on institutionalization delay , institutionalization length or nursing home admission rate.
Among the @number@ home-living participants , @number@ lived alone and @number@ were not looked after by any caregiver.
Among the @number@ individuals who participated in these interviews , @number@ of the previous service users , aged ≥65 years , were sampled.
Among the @number@ men , the mean ( SD ) age was @number@ ( @number@ ) years , and @percent@ were white.
Among the @number@ modifications , AGEs from the Amadori product ( derived from the reaction of glucose and lysine ) and methylglyoxal were dominant.
Among the @number@ MRSA isolates , @number@ % were multidrug-resistant and none carried PVL.
Among the @number@ older elderly patients aged ≥75 years , dyslipidemia was significantly related to acute cerebral infarction ( OR , @number@ ) .
Among the @number@ patients enrolled , @number@ ( @percent@ ) were positive for any one of the @number@ study pathogens.
Among the @number@ patients in our analytic sample , EFV / FTC / TDF use was associated with fewer symptoms than was other cART.
Among the @number@ patients , @number@ developed postoperative delirium ( an incidence of @percent@ ) .
Among the @number@ patients , @number@ died during the initial hospitalization.
Among the @number@ patients ( @percent@ women ) , @percent@ were living in an institution before admission.
Among the @number@ patients without a cancer diagnosis , mortality within @number@ years was @percent@.
Among the @number@ patients with two or more testosterone measurements , @number@ were PCa cases.
Among the @number@ persons with valid MMSE scores , the prevalence of cognitive impairment was @percent@.
Among the @number@ SDS questionnaires , the patients whose conditions were aggravated showed significantly higher scores in diurnal variation , sleep disturbance and weight loss.
Among the @number@ significant GRS-lipoprotein associations in EAs , @number@ were significant in AAs , @number@ in HAs , and @number@ in CHNs.
Among the @number@ stays with APT monotherapy ( @percent@ ) , @number@ ( @percent@ ) displayed an atheromatous disease.
Among the @number@ subjects , @percent@ were female with a median age of @number@ years.
Among the @number@ subjects with gradable fundus photographs , @number@ individuals who had information on all test parameters were included.
Among the @number@ women considered , the last two of the above five categories were pooled together ( > 24 g / day ) .
Among the numerous dental methods that exist for adults aging , the evaluation of root translucency is one of the most useful.
Among the numerous reviewed studies , six trials and three meta-analyses were included in this article.
Among the older participants , hearing acuity predicted the SRT as well as the effect of the novel accent on SRT.
Among the older population in Canada , the majority of whom are women , incurable cancer is rampant.
Among the old there were the young old ( aged 65-74 ) and the older old ( aged 75 + ) .
Among the original variables of Factor @number@ the Fisher linear coefficient showed that the TUG was the most discriminant of the tests.
Among the other @number@ @number@ proteins , the D N A polymerases belonging to the X and Y families have a special place.
Among the overweight children , @percent@ migrated to normal weight status , @percent@ became obese and @percent@ retained their overweight status.
Among the patients who did not undergo surgery , elderly patients did not report higher rates of contraindications to surgery.
Among the patients who presented with hypogonadism-related symptoms , the mean proportion of patients undergoing treatment for LOH was @percent@.
Among the patients who underwent complex PCI ( n = 166 ) , twenty eight ( @percent@ ) were discharged the same day.
Among the @percent@ of patients who reported looking younger , the mean perceived age was @number@ years younger.
Among the person-related factors , loneliness was the strongest predictor of satisfaction among older persons in nursing homes.
Among the physical domains of pre-frailty , low gait speed seems to be the best predictor of future CVD.
Among the PIM groups analyzed , antipsychotics were the most strongly associated with mortality ( HR = @number@ 95%CI @number@ to @number@ ) .
Among the poor , five heterogeneous trajectories with clear patterns were identified : high-to-moderate , stable-high , slightly-increasing , steeply-increasing , and stable-low.
Among the positive individuals , @percent@ were detected for single HPV infection , @percent@ for multiple HPV infections.
Among the possible known risk factors ( diabetes , pregnancy , etc. ) , only aging was found to play a significant role.
Among the post-translational modifications , oxidation and glycation are of special interest , especially in diseases such as diabetes , and in aging.
Among the potentially toxic drugs , antimuscarinics occupy a prominent place.
Among the remaining participants , @percent@ had prediabetes by impaired fasting glucose ( ≥100 mg / dl ) and @percent@ by A1c≥5.7%.
Among the reminder / simplification studies , both studies reported improvements in adherence without a significant impact on related health outcomes.
Among the reversible modifications , the most relevant ones are those arising from cysteine oxidation.
Among the risk factors for cognitive impairment , CKD is increasingly recognized.
Among the robust , older age and previous cancer , hospitalizations , chronic lung diseases , and stroke were risk factors for worsening.
Among these , a gene carrying one of the highest risks for AD is PICALM.
Among these , a total of @number@ patients ( @percent@ ) discontinued anti-TNF therapy after a mean of @number@ months.
Among these carriers , cationic polymers and peptides have been further developed as intracellular organelle-targeted delivery systems.
Among these changes , the most striking are those involving the innate and adaptive parts of the immune system.
Among these compounds , methylglyoxal ( MG ) can yield advanced glycation end products ( AGEs ) , which are crucial in AD pathogenesis.
Among these , comprehensive geriatric assessment ( CGA ) has been demonstrated to effectively improve prescribing practice.
Among these diseases , heart failure ( HF ) and acute myocardial infarction ( AMI ) are the most common causes of hospitalization.
Among these eleven trials , one referred to massage therapy and acupuncture , and the other ten studies referred to bright light therapy.
Among these factors , only education was significantly associated with a cerebral volume including gray and white matter ( p = @number@ ) .
Among these factors , spiritual experiences , religious practices , and compassion were significantly associated with life satisfaction in the overall sample.
Among these factors , the environment is extremely important.
Among these genes , FOS and PTGS2 have been previously reported to be involved in BP-related processes ; the others are novel.
Among these genes , we identified the pluripotency gene Patz1 , which is repressed during myogenic differentiation through direct binding of MyoD to promoter elements.
Among these it promotes advanced glycation end products ( AGEs ) , which are crucial in pathogenesis of human disease.
Among the selected studies , there were four randomised and placebo-controlled trials and the remaining five reports were observational.
Among these miRNAs , miR-137 and miR-195 levels were significantly decreased in AVMs and constituent AVMSMCs.
Among these modifying enzymes , sirtuins , a class III histone deacetylase ( HDAC ) enzymes , are of particular importance.
Among these , MT has the most substantial data.
Among these , @number@ cases were confirmed as conjunctivochalasis , with a prevalence rate of @percent@.
Among these @number@ papers , @number@ were excluded and @number@ were added.
Among these , @number@ ( @percent@ ) had airway hyperresponsiveness at one examination or more during the study period.
Among these , @number@ proteins are part of the recently elucidated human autophagy protein network.
Among these outstanding issues include the necessity of performing longitudinal studies and differentiating between hippocampal and extra-hippocampal contributions to aging in navigation.
Among these , Parkinson's , Alzheimer's and cardiovascular diseases are on the top of the list.
Among these participants , @percent@ had neuropathological diagnoses of Alzheimer disease ( AD ) , and @percent@ of vascular dementia ( VaD ) .
Among these , @percent@ had emergency surgery , @percent@ had complications , and @percent@ died.
Among these , @percent@ men and @percent@ women improved after @number@ years ; @percent@ of men and @percent@ of women worsened.
Among these , quantitative alterations of B lymphocyte subsets determine outcome of infections and vaccination.
Among these subjects , there were @number@ with elevated MMA and high folate.
Among these telomere-independent activities of hTERT , the role of hTERT in gene transcription has been investigated in detail.
Among these , the rotenone-sensitive subunit of complex I NDUFV3 was increased in cells cultured at @percent@ oxygen.
Among these variables , dementia had the strongest impact on care needs increases , especially in persons who lived alone.
Among the seven sirtuins , SIRT2 is predominantly found in the cytoplasm , and is present in a wide range of tissues.
Among these veterans , the most common reasons for nonpsychiatric admission were infection , cardiac disease or altered mental status.
Among these , we identified SETD8 as a new target as well as a key regulator of the cellular senescence signaling.
Among these , we selected miR-181b because of its link with inflammation.
Among the significant variables , health status was revealed to be the strongest factor in housing satisfaction.
Among the six identified terms in the literature , RRA was selected.
Among the skills quantifying hand function , age accounted for the most variance in hand and finger dexterity.
Among the strategies to prevent IPD and PP , vaccination has its place , although vaccination coverage in this group is lower than desirable.
Among the strategies to reduce oxidation in modern first-generation highly crosslinked polyethylenes ( HXLPEs ) , postirradiation remelting was considered to afford the greatest stability.
Among the stress hormones measured , only cortisol increased during hyperglycemia.
Among the studied individuals , @percent@ were found to be heteroplasmic.
Among the Super-Seniors , APOE allele status was not associated with body mass index or Mini Mental State Examination score.
Among the surgical patients , within subject comparison of atrial cell telomere length versus LTL was assessed.
Among the survivors , similar but slightly lower risks of disability @number@ years later were found.
Among the themes , three major categories emerged : cultural factors , structural barriers , and personal barriers.
Among the three human apolipoprotein E ( apoE ) isoforms , apoE4 increases the risk of Alzheimer's disease ( AD ) .
Among the three shoes tested , the shoe with intermediate midsole foam provided the best compromise between viscosity and elasticity.
Among the tissues affected by mitochondrial dysfunction are those with a high-energy demand and thus high mitochondrial content.
Among the top @number@ hits , we find the new interactors TMPO , HNRNPU , RPS3 , RALY , RPS9 DDX21 , and HNRNPM.
Among the underweight children , @percent@ migrated to normal weight status and @percent@ migrated to overweight status.
Among the various symptoms associated with LOH , a visceral fat increase is strongly associated with relatively low levels of testosterone.
Among the very old , females have higher levels of FT4.
Among the very old , the link between social capital resources and loneliness is also highly influenced by health status.
Among this already at-risk population there may be certain characteristics that further exacerbate the risk.
Among those , age and smoking ( P ≤ @number@ ) were related to shorter LTL.
Among those aged 60-80 , the partner's death was a stronger predictor of the incidence of loneliness among men than among women.
Among those aged ≥65 years , @number@ had MIA ( @percent@ of elderly ) .
Among those aged 80-89 years , E ' was significantly lower in female than in male.
Among those assessed to have hypertension , @percent@ were not previously aware of its presence.
Among those aware of their hypertension , only @percent@ were untreated.
Among those classified as frail , @percent@ had disabilities in ADLs , @percent@ in IADLs and @percent@ had comorbidity.
Among those correctly included in the high-risk prescribing denominator , the reported rate of high-risk prescribing was @percent@ and the calculated rate was @percent@.
Among those hemodynamic variables wave reflection but not arterial stiffness had the dominant independent association with ARV.
Among those , multicomponent behavioral group interventions provided the most robust evidence of benefits in improving balance confidence and in decreasing activity avoidance.
Among those not feeling lonely , depression was associated with being previously married.
Among those participants with UI , men and women were at equal risk of experiencing back problems.
Among those proteins , @number@ were upregulated and @number@ were downregulated in the aged group.
Among those reporting disability , mobile home dwellers had fewer bathroom safety modifications.
Among those , the patients with chronic heart failure ( CHF ) are thought to be increasing rapidly although the official report is missing.
Among those who are helped , @percent@ receive informal , @percent@ formal , and @percent@ mixed care.
Among those who had contractures , @percent@ presented with a primary complaint of Dupuytren's disease ( symptomatic contracture ) .
Among those who maintained a stable weight , @number@ women ( @percent@ ) and @number@ men ( @percent@ ) achieved the composite healthy aging outcome.
Among those who responded , @number@ ( @percent@ ) respondents said that they had concerns.
Among those who saved , age , education , perceived financial knowledge , and financial management capacity are related to the amount of savings.
Among those with APOE ε4 , those with positive age beliefs were @percent@ less likely to develop dementia than those with negative age beliefs.
Among those with definite PAD , @percent@ were asymptomatic.
Among those with diabetes , poor glycemic control may increase the risk of an injurious fall.
Among those with difficulties with mobility or other daily activities , @percent@ of frail individuals and @percent@ of non-frail individuals said that they received help.
Among those with higher urine volumes , all placebo subjects and more than @percent@ of calcium supplemented subjects were at lowest risk.
Among those with HIV , atrophy rates did not differ statistically by cognitive status.
Among those with more than six functional limitations , poorer function was associated with fewer physician visits.
Among those without frailty at Wave @number@ the association between pain at Wave @number@ and frailty at Wave @number@ was examined using logistic regression.
Among those without major CVDRFs , HIV + veterans have twice the AMI risk.
Among those with perfect scores in Wave @number@ African Americans declined more rapidly than Whites ( p = @number@ ) .
Among those with tertiary levels of education , late preterm birth was not associated with CERAD-NB scores.
Among transition-age outpatients , the oldest youth had the highest rates of depression and bipolar disorder and co-occurring medical and substance use problems.
Among treatment-compliant patients , HR was @percent@.
Among various methods for analyzing physiological signals , sample entropy ( SE ) is commonly used to quantify the degree of regularity of time series.
Among various pathogens tested , S. flexneri M9OT ( SF ) exhibited highest pathogenicity by killing rack-1 mutant worm-VC3013 earlier when compared to WT.
Among various post-translational modifications affecting APP accumulation , ubiquitination of cytodomain lysines may represent a key signal controlling APP endosomal sorting.
Among weight-maintainers , only obese ( @number@ points ) women showed a greater decline than weight-maintaining normal weight women.
Among white men , BMI was inferior to WC in predicting MetS.
Among women , after adjusting for age and race , this association was no longer significant ( p = @number@ for trend ) .
Among women aged @number@ years and older ( n = @number@ ) , APOE-ε4 was not associated with the lifetime number of children.
Among women aged @number@ years or older , the HPV DNA test with cytology triage tended to have higher specificity than conventional screening.
Among women , a synergistic interaction was observed between GRSrate and red meat intake in association with SUArate.
Among women , being legally married was associated with more LGBT microaggressions.
Among women , greater muscle strength was also associated with lower risk of gait speed decline.
Among women , menopause and older age might additively influence the elevated probability of dysglycemia.
Among women , older baseline age was associated with greater decline in Peak Y ( tm ) .
Among women , significant predictors of multimorbidity were high BMI and smoking.
Among women , the differences between all-cause mortality and nonsmoking-related mortality were small , but larger for rectangularization than for longevity extension.
Among women , those very overweight most of life can expect to die @number@ years sooner and have above average disability duration.
Among workers , those with cognitively demanding work were more likely to experience MC , independent of memory performance.
Among work-related factors , psychosocial work characteristics have the strongest relation with productivity loss , mostly with performance while at work.
Among WPW , naming a health-care proxy was associated with reporting a partner who provided social support.
Among young adults with BD , substance misuse , medication non-adherence , age at onset , and comorbid psychiatric conditions each predict self-harm.
Among young children , hypoallergenic formula prescription rates are more common in the southern and eastern regions of Australia.
Among young men , lower self-esteem can be found.
Among youths 6-11 and 12-19 years , non-Hispanics whites had lower FeNO values than non-Hispanic blacks and Hispanic youths.
A monopolar 1-MHz RF device with uniform heating and perpendicular internal electric fields was used to achieve greater heating within the fat.
A Monte Carlo probabilistic sensitivity analysis assigned appropriate distributions to all input parameters and evaluated model results over @number@ iterations.
A more anterior inferior frontal region was recruited by patients , but did not support successful syntactic processing.
A more conservative approach , averting admission and even antibiotics , is explored.
A more dramatic reduction in CRRTs on the forehead and the canthus was observed in both the 2-8 and the 3-9 o'clock directions.
A more in-depth study was conducted on the @number@ cases in women.
A more proactive , integrated , person-centred and community-based response to frailty is required.
A more recent technology has been developed that employs fractionated bipolar radiofrequency ( RF ) energy.
A more standardized approach in defining and assessing phlebitis among studies is recommended.
A more straightforward interpretation is that telomere attrition provides an aging clock , reliably programming lifespans.
A more thorough chart review was performed on individuals who reported shoulder pain and disability.
Amorphous aggregates are formed first.
A motion capture system and force plates were used to obtain kinematic and kinetic data.
Amount of perinuclear intracytoplasmic fine filaments was also increased in the chondrocytes of osteoarthritic cartilage.
A mouse clinical frailty index ( FI ) was developed based on clinical frailty assessment tools.
A mouse model suggests that the effect may be due , in part , to its effects on lung development and / or repair processes.
Amphotericin B deoxycholate is better avoided because of severe adverse effects.
AMPK activation is suspected to mediate some of the health-protective effects of long-term calorie restriction.
AMPK activity is decreased in human knee osteoarthritis ( OA ) chondrocytes.
AMPK can inhibit endoplasmic reticulum and oxidative stresses which are involved in metabolic disorders and the aging process.
AMPK is directly activated by an increase in AMP : ATP ratio in metabolic stress conditions including hypoxia and glucose deprivation.
AMPK signaling was also inhibited in the brain and heart from Ngb-overexpressing transgenic mice.
Ample evidence indicates that inhibition of translation initiation factor activities enhances stress resistance in model organisms.
Ample evidence is available for phase @number@ ( rationale for use ) and phase @number@ ( discriminative ability between diseased and control subjects ) .
Ample of clinical and experimental evidence has demonstrated that CR is capable of retarding aging process and development of cardiovascular disease.
Amplified prefrontal activity suggests elderly increase cognitive control for negative , highly arousing emotional stimuli , but it is not maintained.
Amplitude and frequency of discrete spindles were calculated with higher reliability than the estimation of spindle duration.
Amplitude and latency were extracted from N170 , and then relations to the contrasts of the images were checked.
Amplitude measurements were found unaltered among all groups.
Amplitude-modulation ( AM ) and frequency-modulation ( FM ) detection thresholds ( AMDTs and FMDTs , respectively ) were assessed for @number@ normal-hearing listeners.
Amplitudes and latencies were collated.
AMS values were not associated with testosterone values but rather were related to insulin resistance , particularly in subjects with moderately severe AMS values.
AMS values were positively correlated with fasting blood glucose , insulin and HOMA-IR values.
A much grimmer picture of the life of elderly patients can be seen in patients with high comorbidity rates.
A much larger @percent@ ( @percent@ confidence interval , @number@ to @number@ ) of the US population older than @number@ years self-reports having glaucoma.
A multicenter cross sectional design was conducted.
A multicenter randomized controlled trial will enroll @number@ HF patients requiring coronary anatomical definition.
A multi centre study for contemporary reference values is recommended.
A multidimensional approach allows a more robust interpretation of the various relationships between the markers.
A multidimensional assessment that addresses airway problems , comorbidities , risk factors , and management skills will draw attention to key needs for intervention.
A multidisciplinary analysis restricted to validated reports was applied to the cause and management of irritable bowel syndrome and diverticular formation and subsequent diverticulitis.
A multidisciplinary approach to the senior adult cancer patient is mandatory , to assure optimal diagnosis and therapeutic management.
A multi-disciplinary approach would enable each profession to share their expert knowledge in order to facilitate better or safer patient care.
A multidisciplinary expert panel ( blinded to treatment assignments ) adjudicated study outcomes.
A multidisciplinary team drafted a preliminary set of @number@ items.
A multifactorial intervention targeting the identified factors would reduce dizziness in older people.
A multifunctional skin physiology monitor was used to measure SC hydration.
A multigroup ( ethnicity ) path analysis was performed , and an intercept invariant multigroup model fits the data best.
A multilevel hierarchical model described performance at patient , hospital and regional level.
A multilevel logistic regression analysis was applied to assess factors affecting compliance with standards of care.
A multilevel multinomial model was applied to quantify the socioeconomic impact across different age , diseases and disease groups , both separately and in combination.
A multilevel statistical analysis , a method that respects the hierarchical data structure , was used.
A multilocus score comprised @number@ genetic markers demonstrated an estimated 5-fold gradient in AF risk.
A multimodal rehabilitation program seems to be a good working model for achieving this goal.
A multinomial logistic model was applied to analyze the factors associated with the desired aging care models.
A multinomial regression model was used to predict sociodemographic characteristics associated with polypharmacy and hyperpolypharmacy.
A multiple-case study was conducted with eight nonoccupational therapists trained to use Algo and filmed while using it with six standardized clients.
A multiple correspondence analysis followed by clustering was carried out to identify the typology of falls.
A multiple phenotype analysis in KORA F4 combining all aging measures showed that BC and PM10 were broadly associated with biological aging in men.
A multiple regression analysis accepted central abdominal fat and telomere length as significant predictors of CER ( R2 = @number@ ) .
A multiple regression analysis showed a relationship between the mtDNA haplogroups and serum levels of the typical collagen type II markers.
A multiple regression analysis was conducted to estimate a model of factors that connected with PLO.
A multiple regression analysis was constructed for each cognitive domain separately , with scores on the LSI-A as the dependent variable.
A multi-pronged program with detailed action steps was developed and directed at key stakeholders and health conditions.
A multiprotein cascade operates at sites of DNA double-strand breaks ( DSBs ) to recognize , signal and repair damage.
A multisector effort is also required to support patients and their clinicians to have meaningful discussions concerning the risk-benefit ratio of osteoporosis treatment.
A multisensory training approach seems to obtain better results in the elderly with regard to both balance and quality of life.
A multisite , prospective observational study was conducted in residents aged @number@ and over of @number@ LTC facilities.
A multisite quasi-experimental control group design with a connected qualitative component was used.
A multistage cluster sample composed of @number@ individuals representative of @number@ inhabitants of São Paulo city aged ≥60 years in @number@ was analyzed.
A multi-stage sampling method was used to collect views of community-dwelling older people from two local districts of Hong Kong.
A multitude of etiologies for late-life psychosis exist , the two most prototypical being schizophrenia and psychosis of Alzheimer disease ( AD ) .
A multivariable analysis identified risk factors for polypharmacy.
A multivariable Cox proportional hazards model was fitted to assess the relative risk of hospitalization controlling for demographic and other comorbidity variables.
A multivariable logistic regression analysis was performed to test the association between sensory extinction and demographic and clinical risk factors.
A multivariable mixed effect model was used to evaluate associations among these parameters.
A multivariate analysis revealed no significant association between the expression status of MRP1 , MDR or BCRP and the OS.
A multivariate analysis revealed that the presence of complex plaque was an independent predictor of renal impairment.
A multivariate analysis showed that older age , early diagnosis , and brain metastasis were each associated with a poor prognosis.
A multivariate Cox proportional hazards model showed sugar intake and occupational exposure to carbon tetrachloride were independently and significantly associated with development of GBM.
A multivariate general linear model demonstrated a significant interaction between ROIs and cognitive-behavioral functions.
A multivariate hierarchical logistic regression analysis was performed.
A multivariate linear regression model adjusted for clinical and socioeconomic variables was used to analyze the association between depressive symptoms and functional performance.
A multivariate linear regression model analyzed determinants of SOC.
A multivariate logistic model was run for our global successful aging measure.
A multivariate logistic regression model including demographic , clinical and genetic parameters was performed to assess the relationship between sUA and cognitive impairment.
A multivariate logistic regression model was constructed to identify the risk factors of poor nutrition.
A multivariate mixed-effects regression model was used to determine the effect of face-lift surgery.
A multivariate multiple regression model with normal errors was used for the statistical analysis.
A multivariate regression analysis demonstrated that SHIM score was an independent factor affecting cardiovascular risk ( OR : @number@ 95%CI : @number@.637-0.995 ) .
A multivariate regression analysis revealed triglyceride and hs-CRP levels to be the best predictors of PAI-1 within COPD.
A multivariate regression analysis showed that the LF , HF and heart rate were independent determinants of the c / a.
A multivariate regression was used to determine factors associated with HOMA-IR.
A multivariate repeated-measures analysis of variance indicated main effects of group and SNR and an interaction effect between these factors on the pupil response.
A murine model for AD shows that reduced IGF-1 signaling prevents AD-like characteristics.
A muscle that has been crushed can regenerate fully both structurally and functionally within a month.
A musical training survey examined self-reported musical experience and objective knowledge in @number@ cognitively intact participants.
A mutation in the BRAF gene was also identified in one pRCC1.
Amylin and β-amyloid ( Aβ ) may share common pathophysiology and show strikingly similar neurotoxicity profiles in the brain.
Amylin oligomerization in the brain appears to be a novel risk factor for developing AD.
Amyloid- and FDG-PET scans showed typical results of Alzheimer's disease.
Amyloid and tau pathology in aged chimpanzees suggests these AD lesions are not specific to the human brain.
Amyloid beta-induced synaptic damage , mitochondrial abnormalities , and phosphorylated Tau are major areas of present research investigations.
Amyloid-beta peptides ( Aβ ) , implicated in Alzheimer's disease ( AD ) , interact with the cellular membrane and induce amyloid toxicity.
Amyloid deposition is mainly seen in the myocardium , resulting in arrhythmia ( atrial fibrillation ) and / or heart failure.
Amyloid deposits ( Aβ-D ) and neurofibrillary tangles ( NFT ) are pathological changes related to AD involving hippocampal regions.
Amyloid deposits were seen in the vasculature , the mucosal and muscle layer of both heterozygous and wild type mice.
Amyloid diseases ( amyloidoses ) are widespread in the elderly human population , a rapidly expanding demographic in many global populations.
Amyloid images with amyloid-binding positron emission tomography ligands can detect CAA , although they cannot discriminate vascular from parenchymal amyloid deposits.
Amyloid imaging positivity appears to begin near age @number@ years in cognitively intact APOE4 carriers and age @number@ years in APOE4 non-carriers.
Amyloid-like inclusions have been associated with Huntington's disease ( HD ) , which is caused by expanded polyglutamine repeats in the Huntingtin protein.
Amyloidogenic processing of amyloid precursor protein ( APP ) by β- and γ-secretases leads to production of Aβ.
Amyloidoses are a group of protein-misfolding disorders that are characterized by the deposition of amyloid fibrils in organs and / or tissues.
Amyloid PET was positive.
Amyloid plaques , the hallmark of Alzheimer's disease ( AD ) , contain fibrillar β-amyloid ( Aβ ) 1-40 and 1-42 peptides.
Amyloid positron emission tomography scanning will be standardized using the Centiloid method.
Amyloid precursor protein and α-synuclein protein involved in AD and PD are copper binding proteins , respectively.
Amyloid precursor protein ( APP ) and its cleavage products including Aβ have been suggested as homeostatic regulators of synaptic activity.
Amyloid precursor protein ( APP ) expression levels in intestine significantly increased in AD mice revealing its toxicity.
Amyloid precursor protein ( APP ) expression was reduced through small interfering RNA ( siRNA ) technique.
Amyloid precursor protein mice with significant CAA developed more extensive hemorrhages which also appeared sooner after exposure to MMP-9.
Amyloid-related imaging abnormalities were noted in less than @percent@ ( 8 / 885 ) of participants.
Amyloid was measured on a subsample ( n = @number@ ) and was included only in a secondary index.
Amyloid was not a significant predictor in any model.
Amyloid-β1-42 immunoreactivity was observed in the entire cholinergic neuronal population regardless of age or Alzheimer's disease diagnosis.
Amyloid-β accumulation may be a contributor to or biomarker of declining cognitive functioning in preclinical AD in DS.
Amyloid-β ( Aβ ) peptide-binding alcohol dehydrogenase ( ABAD ) , an enzyme present in neuronal mitochondria , exacerbates Aβ-induced cell stress.
Amyloid-β ( Aβ ) peptide is a key component of amyloid plaques , one of the pathological features of Alzheimer's disease.
Amyloid β ( Aβ ) peptides are important components of plaques in Alzheimer's disease ( AD ) .
Amyloid-β ( Aβ ) plaques and neurofibrillary tangles are pathological indicators of AD.
Amyloidβ₁₋₄₂ could not be detected , pointing to a different amyloid composition than that found in senile plaques in the mice's brains.
Amyloid-β deposition in senile plaques is one of the main pathological changes in Alzheimer's disease ( AD ) .
Amyloid-β peptide Aβ ( 25-35 ) was shown to cause lysis of rat erythrocytes of different ages.
Amyloid-β-peptide ( Aβ ) is considered to be the toxic species in AD and causes cell death in the affected areas of patient's brain.
Amyloid β-peptide ( Aβ ) is directly linked to Alzheimer's disease ( AD ) .
Amyloid-β peptide ( Aβ ) , the cerebral accumulation of which is thought to cause Alzheimer's disease ( AD ) , is produced throughout life.
Amyloid β-protein ( Aβ ) aggregation is considered to be a critical step in the neurodegeneration of Alzheimer's disease ( AD ) .
Amyloid β-protein ( Aβ ) , which plays a central role in AD pathogenesis , is reported to accumulate within mitochondria.
Amyotrophic lateral sclerosis ( ALS ) is a complex neurodegenerative disease with cellular and molecular mechanisms yet to be fully described.
Amyotrophic lateral sclerosis ( ALS ) is a devastating and incurable neurodegenerative disease , characterised by progressive failure of the neuromuscular system.
Amyotrophic lateral sclerosis ( ALS ) is a devastating motor neuron disease including about @percent@ of genetically determined forms.
Amyotrophic lateral sclerosis ( ALS ) is a fatal , neurodegenerative condition characterized by loss of motor neurones and progressive muscle wasting.
Amyotrophic Lateral Sclerosis ( ALS ) is a fatal neurodegenerative disease characterized by progressive motor neuron degeneration in the brain and spinal cord.
Amyotrophic lateral sclerosis ( ALS ) is a fatal neurodegenerative disease that arises from the progressive degeneration of the motor neurons.
Amyotrophic lateral sclerosis ( ALS ) is a fatal neurodegenerative disorder involving the progressive degeneration of motor neurons in the brain and spinal cord.
Amyotrophic lateral sclerosis ( ALS ) is a fatal progressive neurodegenerative disorder.
Amyotrophic lateral sclerosis ( ALS ) is a heritable neurological disease for which the underlying genetic etiology is only partially understood.
Amyotrophic lateral sclerosis ( ALS ) is an adult-onset neurodegenerative disease characterized by loss of motor neurons.
Amyotrophic lateral sclerosis ( ALS ) is an adult-onset neurodegenerative disorder.
Amyotrophic lateral sclerosis ( ALS ) is a neurodegenerative disease characterized by the death of motor neurons.
Amyotrophic lateral sclerosis ( ALS ) is a neurodegenerative disease of motor neurons resulting in progressive paralysis.
Amyotrophic lateral sclerosis ( ALS ) is a neurodegenerative disease that selectively affects motor neurons in the cortex , brain stem , and spinal cord.
Amyotrophic lateral sclerosis ( ALS ) is a progressive neurodegenerative disease affecting motoneurons in the brain and spinal cord leading to paralysis and death.
Amyotrophic lateral sclerosis ( ALS ) is a progressive neurodegenerative disorder affecting predominantly motor neurons.
Amyotrophic lateral sclerosis ( ALS ) is a progressive neurodegenerative disorder characterized by damage of motor neurons.
Amyotrophic lateral sclerosis ( ALS ) is as an adult-onset neurodegenerative disorder involving both upper and lower motor neurons.
Amyotrophic lateral sclerosis ( ALS ) is a severe neurodegenerative disease principally affecting motor neurons.
Amyotrophic lateral sclerosis ( ALS ) is a severe neurodegenerative disease with a complicated pathogenesis.
Amyotrophic lateral sclerosis ( ALS ) is one of the diseases that would benefit from this prospect.
Amyotrophic lateral sclerosis ( ALS ) is the most common motor neuron disease in populations of European descent.
Amyotrophic lateral sclerosis ( ALS ) is the most prevalent neuromuscular disease worldwide.
Amyotrophic lateral sclerosis is a late-onset degenerative disease affecting motor neurons in the spinal cord , brainstem , and motor cortex.
An 11-item medication adherence questionnaire , modeled after the Morisky medication adherence questionnaire , was administered.
An 11-item scale was used to measure participants ' trust in physicians.
An 80-year-old man developed dysarthria , quadriplegia , sensory disturbance and ataxia in all limbs.
An 82-year-old white man presented with an exophytic papule of the ear clinically suspicious for basal cell carcinoma.
An 83-year-old female , who had a history of anterior myocardial infarction , was treated for Alzheimer's disease with donepezil.
An 87-year-old man was brought to our emergency department because of choking on food during his dinner.
An 88-year-old man was admitted with fatigue , dizziness , and heart palpitations.
An 8-week exercise intervention focusing on resistance exercises neither benefits cognitive function nor affects the levels of the serum proteins analysed in nonagenarians.
An AABFC would set a near-youth homeostatic titer of ARMs in the blood.
An aberrant oxygen environment at birth increases the severity of respiratory viral infections later in life through poorly understood mechanisms.
An ability to separate natural ageing processes from processes specific to morbidities is required to understand the heterogeneity of age-related organ dysfunction.
Anabolic hormone profiles did not associate with BMI , blood pressure , or sleep efficiency.
Anabolic resistance is also a hallmark of a sedentary lifestyle at any age.
Anabolic steroid implants are commonly used to increase growth performance and carcass leanness.
An absence of parasitism makes the US population ideal to test the hypothesis that the maternal immune system recognizes a fetus as a parasite.
Anacardic acid , a p300 histone acetyltransferase inhibitor , rescued the UV-induced decrease of type I procollagen expression in human dermal fibroblasts.
An accelerated ageing determines a frail status.
An accelerated rate of biological aging could contribute to this increased risk.
An acceleration of hippocampal atrophy may emerge and start around @number@ years of age in a non-demented elderly population.
An accelerometer was worn for @number@ consecutive days at home.
An account of work performed at the UNA laboratories since @number@ on the detection and description of interlaminar glial processes , is presented.
An accumulation of multiple VRFs , especially in middle age ( 40-59 years of age ) , can substantially increase dementia risk.
An accurate description of changes in the brain in healthy aging is needed to understand the basis of age-related changes in cognitive function.
An accurate nasal obstruction evaluation in the elderly is becoming of increasing interest for medical doctors , especially for geriatricians.
An accurate pain assessment is the foundation for treating pain ; yet , thorough pain assessments and regular reassessments are too often neglected.
An active ageing assessment questionnaire and WHOQOL-BREF - quality of life assessment were applied.
An active cognitive lifestyle has been suggested to have a protective role in the long-term maintenance of cognition.
An active ingredient contributing to the observed activities was identified as silibinin.
An active life style can postpone the aging process , prevent many aspects of functional decline and improve health and quality of life.
An actor-partner interdependence model using AMOS version @number@ ( Europress Software , Cheshire , UK ) was used to analyze the dyadic data.
An acute rise in metabolic demand causes vasodilation in systemic circulation while a chronic shift in bioenergetic profile may lead to vascular diseases.
An adapted Aristotle score was developed to classify procedures based on surgical risk.
An adapted phenotypic frailty scale was constructed in the sample common to both waves ( n = @number@ ) .
An adaptively sized tetrahedral mesh modeling approach is described that is capable of producing meshes conforming precisely to the voxelized regions in the image.
An adaptive response in the nonTg hippocampus was a shift to transport and utilization of ketone bodies as an alternative fuel.
An addiction-like tendency toward certain foods may contribute to overeating.
An addiction may be discovered by chance late on , delaying diagnosis and treatment.
An additional aim was to estimate direct health care costs for both groups.
An additional aim was to investigate whether declines in vision differentially affect secondary more than primary memory.
An additional analysis compared incidence of stroke or TIA in participants with and without DAo plaques.
An additional analysis noted this rate could be as high as @percent@.
An additional ankle DF / PF exertion task was performed.
An additional aspect of this article is a review of the pertinent literature published from @number@ to @number@ on ageing and longevity of digeneans.
An additional benefit of the analytical approach presented is that it allows for assessment of the utility of triggered sampling in longitudinal studies.
An additional burden of wound healing is the problem of skin scarring , a $ 12 billion annual market.
An additional control group of wild-type mice was also used.
An additional multiancestral replication cohort of @number@ patients with AD and @number@ controls without dementia was used to validate suggestive findings.
An additional , novel finding of our study was that the ε2-allele might favor EL , at least in the Italian and Japanese cohorts.
An additional novel locus for BUA was seen in the male-specific analysis at DEFB103B ( 8p23.1 ) ( P = @number@ × 10-6 ) .
An additional novel locus ( SPRYD7 / DLEU2 ) was identified for WHRadjBMI when combined with European GWAS.
An additional @number@ articles were identified by screening the reference lists for included articles.
An additional @number@ per @number@ older adults would survive , above the background survival rate of Std-ALS , if given CCR.
An additional @number@ were studied with the beta-amyloid specific PET with tracer ( @number@ ) C-labeled Pittsburgh Compound-B ( PIB ) .
An additional objective was to examine possible contamination from devices in phlebotomy process.
An additional self-reporting tool such as the PSS-10 could , therefore , be used in such under-reporting circumstances.
An additional subset of human infant BVs was examined for viscoelastic recovery between two cycling episodes.
An additional three-way ANOVA was conducted for each of the @number@ channels , and a P value distribution map was created.
An adeno-associated viral vector expressing vascular endothelial growth factor ( AAV-VEGF ) was injected into the brain to induce focal angiogenesis.
An adenylate cyclase inhibitor obviously suppressed ALP and BMP / Smad signal transduction induced by BMP9 or the combination of BMP9 and FSHβ in MEFs.
An adequate intake of energy , protein , fiber , other nutrients and fluids should be guaranteed.
An adequate kyphotic or lordotic angle has also not been determined.
An adequate number of nurse graduates is imperative to meet societal demands ; however , this is complicated by high nursing student attrition rates.
An adequate vitamin C status might be particularly important for protection against AD and other clinical manifestations of vascular and cognitive ageing.
An adjusted logistic regression analysis , taking as reference those in the @number@ highest quintiles of the aMED score , confirmed these findings.
An adjuvant treatment algorithm for various risk levels of AK was developed.
An advanced polyp was detected in @percent@ of patients with MetS , compared to @percent@ of patients without MetS.
Anaemia in older age has undesirable health outcomes , including increased susceptibility to falling and depression.
Anaemia in the elderly is always associated with a poor prognosis that is in terms of mortality , morbidity and risk of fragility.
Anaemia is a problem that affects almost @percent@ over @number@ years and @percent@ over @number@ years.
Anaemia was defined according to World Health Organization criteria.
Anaesthesia was induced with remifentanil and propofol using a target-controlled infusion.
An aesthetically pleasing neck is an important component of physical appearance and a frequently targeted area for a variety of rejuvenative procedures.
An age-adjusted WLR was created to test influences on WLR independently of age.
An age and sex-adjusted prevalence estimate of RBD and idiopathic RBD in the Korean elderly was @percent@ and @percent@.
An age-associated androgen decrease and its pathological conditions are defined as late-onset hypogonadism ( LOH ) .
An aged series of GRN-deficient and wild-type mice were compared by histology , immunohistochemistry , and electron microscopy.
An Age-Friendly Portland Advisory Council was formed to guide the development of an action plan , monitor progress over time , and suggest additional research.
An ageing population is a typical feature of many developed countries across the world.
An ageing study was conducted to capture skin colour parameters in the CIELab system from Caucasians of both genders and all available adult ages.
An age-related association of blood pressure in the non-hypertensive range ( non-hypertensive blood pressure ) to the cardiovascular mortality has been demonstrated.
An age-related decline of tetanus- and diphtheria-specific BM plasma cells was observed , whereas influenza A- and cytomegalovirus-specific BM plasma cells were not affected.
An age-related decrease in the capacity of CD34 ( + ) cells to generate myeloid cells was also seen in colony-forming assays in vitro.
An age-related difference was identified in the ability to learn an incidental structure under certain conditions and a strategy explanation for the difference was investigated.
An age-related effect was observed in static postural performance during dual-tasking.
An ' aggregation-prone ' heptapeptide ( ( @number@ ) KLRALLT ( @number@ ) ) was located within the NT-proANP sequence.
An aging America presents challenges but also brings social and economic capital.
An aging cohort of patients with HCV could partly explain our findings.
An aging , comorbid , and often unfit population increasingly affected by bladder cancer poses significant challenges in management of individual patients.
An aging dentist workforce in Iowa could put a strain on the public's ability to access dental care , especially in rural counties.
An aging experiment determined the NNR in e-liquids and aerosols as a function of time since initial exposure to air and storage condition.
An aging population and epidemiological transition involves prolonged terminal illnesses and an increased demand for end-stage support in health services , mainly in hospitals.
An aging population and improved survival from cardiovascular diseases is expected to further increase HF prevalence.
An aging population is best served by social , personal , and health support focused on maintaining and maximizing personal independence.
An aging population means more comorbidities and potentially more drug-drug interactions for providers to manage.
An aging population with increased comorbidities makes endovascular treatment a more attractive treatment option.
An aging sexual stigma index was formulated from the attitudinal items of the Aging Sexual Knowledge and Attitudes Scale.
An aging trend was observed for prostate cancer patients.
An aging workforce and high-stress environments have led to more nurses working with their own health problems , which in turn affects productivity.
An agreement with an international common definition is necessary to develop screening and to reduce the morbidity in older persons.
An aim of this study was to examine if certain features of inflammation changed in brains with increasing LB pathology.
An alarming and ironic observation is that several studies found higher risks with fresh RBCs after correction for confounding.
Analgesics and non-steroidal anti-inflammatory drugs ( NSAIDs ) are the only therapeutic treatment options for OA.
Analgesics given and the type of medical staff that was involved were documented.
An almost perfect inter-rater agreeability ( κ ≥ @number@ ) was obtained for the FMAP.
Analog-based free testosterone and immunoassay-based total testosterone were determined by immunoassay.
Analogical reasoning is critical for making inferences and adapting to novelty.
Analogously , interference from similar representations during retrieval is a major cause of age-related memory failures.
Analogously suppression of TXNIP expression can potentially be utilized as an index of restoration of cardiovascular homeostasis.
Analogous model calculations were performed for women and men tested positive or negative with fecal immunochemical tests.
Analogous to phosphorylation and other posttranslational modifications , S-nitrosylation can regulate the biological activity of many proteins.
Analogous to the role of IAP in the gut , TNAP expression in the liver may have a proactive role from bacterial endotoxin insult.
An already low rate of incidents of physical aggression per client month ( @number@ ) was reduced by @percent@ following the implementation of programmatic enhancements.
An alternate and complementary approach to these human studies is through the use of mouse models.
An alternative approach is to identify molecules that have multiple biological activities that are relevant to the disease.
An alternative approach is to manipulate the hormonal status of participants directly.
An alternative approach is to use first a screening tool to detect high-risk patients and then perform CGA in these patients only.
An alternative approach may be to target signaling events downstream of β-amyloid and even tau.
An alternative donor can be considered based on institutional protocols and expertise.
An alternative explanation on the prevalence of hobbies is that the creative sector is overrepresented on Twitter compared to @number@ Census data.
An alternative hypothesis is that PD pathology is governed by regional or cell-autonomous factors.
An alternative interpretation of the same data plus data mostly ignored by Hanahan and Weinberg is proposed , based instead on evolutionarily relevant premises.
An alternative is primary prevention , in which all seniors are screened , referred as appropriate , and educated regarding falls risk.
An alternative is to use a semiautomatic tool for preparation of a homogenate of the muscle biopsy.
An alternative non-linear theory is discussed for the relationship between modernization and the societal views on aging.
An alternative strategy is to characterize the data to an ex-Gaussian function.
An alternative to compression is US-guided thrombin injection ( UGTI ) of the FPA.
An alternative to disease-centric therapeutic approaches is that of ' geroscience' , which aims to define molecular mechanisms that link age to overall disease risk.
Analysed data included initial presenting complaint and clinical examination , hematological and microbiological tests together with ultimate patient outcome.
Analyses accounted for nesting within LLFS families.
Analyses adjusted for age , sex , race , comorbidities , ABI , physical activity , and other confounders.
Analyses adjusted for covariates linked with non-adherence in prior studies.
Analyses also account for other relevant psychological , individual , and country differences.
Analyses are based on the National Survey of Midlife Development ( MIDUS ) , a 2-wave panel survey of adults in the contiguous United States.
Analyses based on pure ENS tissue can more effectively reflect the ongoing changes during pathological processes.
Analyses by beta-blocker type , by cancer site , cancer stage and by cumulative dose showed no significant survival improvements for beta-blocker users.
Analyses by histologic sub-type were included.
Analyses calculated the types of diagnoses and evaluated associations between published criteria and prescribing.
Analyses conditioned on rs4917 indicated that the strong association with the AHSG locus stems from additional independent associations of multiple variants among European Americans.
Analyses controlled for demographics , insomnia symptoms , the previous day's experiences and sleep measures , and additional day-level covariates.
Analyses controlled for several patient characteristics.
Analyses designed to quantify selection bias suggested upward bias.
Analyses employed Mann-Whitney tests and Spearman correlations.
Analyses examined whether Wave @number@ ( @number@ ) relationship quality and stress were associated with changes in blood pressure over time.
Analyses focused on @number@ conditions : angina , arthritis , asthma , chronic lung disease , depression , and hypertension.
Analyses focused on outcomes indicating a serious disposition defined as hospitalization , patient transfer or death.
Analyses focused on the @number@ patients with dementia who completed the Neuropsychiatric Inventory on @number@ or more occasions.
Analyses ( for each gender ) : @number@ ) estimation of a discreet factor ( DFactor ) model based on the frailty variables using LatentGOLD.
Analyses further showed a significant association between trait mindfulness and executive function , namely set shifting.
Analyses included analysis of variance , analysis of covariance , linear , and nonparametric regression models.
Analyses included cohort members of European descent from whom genetic data had been obtained.
Analyses included Cox regression models adjusted for key covariates.
Analyses included latent growth modeling ( LGM ) , latent class growth modeling ( LCGM ) , and logistic regression models.
Analyses included @number@ participants.
Analyses included ordered logistic regression and Cox Proportional Hazards regression.
Analyses indicated significant improvements in knowledge , attitudes , and social skills related to older people in the intervention group compared to the control group.
Analyses indicated that range in reaction time could be used as an indicator of IIV.
Analyses in @number@ independent FTD cohorts and a group of autopsy-verified or biomarker-enriched cases confirmed the larger group analysis.
Analyses in the present article show that encoding by enacting seems to profit especially from remembering the last items of a presented list.
Analyses of both measures indicated caloric restriction slowed biological aging.
Analyses of control , MCI , and Alzheimer disease cases revealed significant differences in brain and hippocampal volumes between each group.
Analyses of covariance ( ANCOVA ) compared discrepancy scores across two groups controlling for age and education.
Analyses of covariance were conducted to examine changes in physical function between the two conditions at the end of the intervention to 6-month follow-up.
Analyses of covariance were performed to evaluate the relationship between different calf circumference and physical function.
Analyses of covariance were used to determine differences between groups.
Analyses of data from long-term studies and studies of the elderly showed similar results.
Analyses of e-liquids inconsistently report nicotyrine , a nicotine analog that could impede nicotine metabolism , raising questions about nicotyrine formation.
Analyses of individual differences revealed that older adults with higher category fluency were more likely to show the young-like pattern.
Analyses of @number@ studies separately measuring left and right hippocampal atrophy ( n = 1142 ) provided little evidence of laterality effects.
Analyses of postoperative pain trajectories were performed using a linear mixed-effects model.
Analyses of pre- and post-disaster SF-36 scores yielded changes in physical function and bodily pain.
Analyses of quantitative and qualitative data were undertaken.
Analyses of quantitative susceptibility mapping ( QSM ) images showed a higher inter-rater agreement reflected by increased Dice-coefficients.
Analyses of reaction time data suggested that for both young-old and old-old , these costs were greater , implying differential resource allocation cost trade-offs.
Analyses of the results for these objectives will determine the relationship between immune function and the training outcomes.
Analyses of the time to need of nursing care revealed similar results.
Analyses of undirected connectivity revealed a global , synesthesia-specific hyperconnectivity in the alpha frequency band.
Analyses of variance and regression analyses were applied to the data.
Analyses of years since cessation , smoking duration , and pack-years of smoking all support the hypothesis that increased cigarette use shortens TL.
Analyses revealed age-related CBF differences during rest ; the youngest group showed greater CBF than 12-year-olds or adults.
Analyses revealed little age-difference in segmentation behavior.
Analyses revealed that the degree to which an individual holds attitude-behavior consistency beliefs in the dishonesty domain accounted for age-related differences in the correspondence bias.
Analyses revealed that the study sample was representative of Maryland older drivers with respect to age and indices of prior driving safety.
Analyses similar to those described here will be useful to understand the functional significance of Oc γ-carboxylation in human health and disease.
Analyses support three major findings : @number@
Analyses tested genetic associations with body-mass index ( BMI ) , waist-height ratio , obesity , and change in BMI over time.
Analyses that overlook the association between cognitive decline and mortality may underestimate the effect of diabetes on cognitive aging.
Analyses took into account repeated observations within each individual.
Analyses uncovered differing threshold levels across emotions and sex of facial stimuli , ranging from @percent@ up to @percent@ intensities.
Analyses used intention-to-treat methods.
Analyses utilized entry data from participants in the Hawaii Aging with HIV-Cardiovascular ( HAHC-CVD ) study.
Analyses were adjusted for age and sex.
Analyses were adjusted for age , height , weight , smoking , follow-up time , vertebral fractures , and prevalent spinal degeneration.
Analyses were adjusted for age , sex , and education.
Analyses were adjusted for age , sex , education , intelligence , vascular disease , physical functioning and co-occurring brain changes.
Analyses were adjusted for age , sex , family relations , education , and site.
Analyses were adjusted for age , sex , physical activity , smoking , diabetes , hypertension , and previous myocardial infarction or stroke.
Analyses were adjusted for confounders.
Analyses were adjusted for potential confounders , including demographic characteristics , lifestyle habits , comorbidities , nutrient intake , medications , and objective parameters.
Analyses were adjusted for relevant confounders , including health and performance status.
Analyses were adjusted for selection bias to broaden generalizability of results to @number@ eligible participants in the ACT cohort.
Analyses were adjusted for socio-demographic and behavioral characteristics , season , and chronic conditions.
Analyses were adjusted for such factors as age , education , height , smoking , and fruit and grain consumption ) .
Analyses were adjusted using propensity scores.
Analyses were also adjusted for confounders ; baseline physical functional ability and depressive symptoms.
Analyses were also conducted to assess for potential interactions between LCPUFAs and lutein / zeaxanthin and none were found to be significant.
Analyses were based on @number@ diagnosis groups incorporating all ICD-10 diagnoses of chronic diseases with a prevalence ≥ @percent@.
Analyses were based on the intent-to-treat principle.
Analyses were carried out separately for estrogen receptor ( ER ) positive ( ER + ) and ER negative ( ER- ) disease.
Analyses were censored for competing events and adjusted for multiple confounders.
Analyses were conducted between @number@ and @number@
Analyses were conducted in 2012-2013.
Analyses were conducted in 2014-2015.
Analyses were conducted in @number@
Analyses were conducted in @number@ community-living adults enrolled between @date@ and @date@ , after excluding @number@ participants for missing values of the variables of interest.
Analyses were conducted in @number@ participants with complete demographic , clinical , genetic , and dopamine transporter imaging data.
Analyses were conducted separately for males and females.
Analyses were conducted using a modified grounded theory framework.
Analyses were conducted using continuous , as well as categorical GDS score levels.
Analyses were conducted using Generalized Estimating Equation model.
Analyses were conducted using logistic , proportional odds , and linear regression models , depending on the outcome and adjusting for age.
Analyses were conducted with and without adjustment for sex , marital status , education , English-language proficiency , nativity , and insurance status.
Analyses were controlled for age and sex.
Analyses were done in terms of clinical disease severity , genotype-phenotype correlations , and body composition and fat deposition alterations.
Analyses were limited to antiretroviral-naïve subjects to focus on the impact of HIV disease itself.
Analyses were made medical history by questionnaire of our own design.
Analyses were performed for motor and cognitive performance , and relative DT costs ( DTCs ) .
Analyses were performed in ethnically homogenous Polish Caucasians.
Analyses were performed in @number@ with Cox models adjusted for the main confounders , and were stratified by obesity and functional limitations.
Analyses were performed longitudinally in @number@ PLWHA , before and about 6-12 months after cART initiation.
Analyses were performed separately in each study and combined using inverse variance meta-analysis.
Analyses were performed using classification and regression tree analysis , Cohen's kappa , and Cox models.
Analyses were performed using Cox proportional hazards regression.
Analyses were performed using Cox regression and adjusted for the main confounders.
Analyses were performed using linear mixed models with DNA methylation as dependent variable.
Analyses were repeated among participants who survived to the age of @number@ years or older and participated in the 2000-2001 examination.
Analyses were repeated excluding participants diagnosed with dementia , with no substantive change to the outcomes.
Analyses were repeated in the subsamples of patients with and without dementia.
Analyses were replicated in age- and sex-matched subsamples.
Analyses were restricted to persons without clinical dementia and reporting no need for help performing any task in the particular functional domain assessed.
Analyses were restricted to women free of any of the @number@ chronic conditions at the time of oophorectomy ( or index date ) .
Analyses were restricted to women of European ancestry.
Analyses were stratified according to sex.
Analyses were stratified by age ( 54-64 years vs 66-76 years ) because many safety-net programs commence around age @number@ years.
Analyses were stratified by age at the time of bilateral oophorectomy ( in tertiles ) .
Analyses were stratified by age group ( 45-64 , 65-79 and ≥ @number@ years ) and sex and adjusted for age and country of birth.
Analyses were stratified by sex and controlled for covariates.
Analyses were stratified by sex and partner status.
Analyses were stratified by sex ( @number@ women and @number@ men ) , and age and BMI were examined as possible effect modifiers.
Analyses within the PReCaP hospital comparing patients pre-and post-implementation of the PReCaP showed no improvement over time in functioning , depression , and HRQoL.
Analyse the influence of lean mass on bone mineral density , related to physical activity , in elderly women.
Analysing mean swimming performance , post-hoc results ( p < 0.01 ) show no consistency in RAE.
Analysis adjusted for age , sex , and / or cystatin-C levels.
Analysis based on data from the Statutory Pension Insurance ( GRV ) shows higher migrant mortality risks in the age group from @number@ to @number@
Analysis by binary ordered logistic regression showed that anemia status did not depend on urban or rural residence or on age.
Analysis consisted of thematic coding by multiple coders.
Analysis employed a hierarchical probit model ( HOPIT ) .
Analysis found common categories across focus groups that explain the phenomenon of LGBT senior housing.
Analysis included demographic details , clinical outcome ( Glasgow Outcome Scale , modified Rankin Scale [ mRS ] ) , and repeat vascular imaging.
Analysis included descriptive statistics for all the demographic and outcome variables.
Analysis in @number@ participants assessed the differential rates of decline in PF across a period of @number@ years for the ILI and DSE groups.
ANALYSIS : Intention-to-treat.
Analysis of acetic , propionic , and butyric acid concentrations was performed using gas chromatography-mass spectrometry.
Analysis of age-matched SApT mice revealed that pathological tau phosphorylation was increased in these brain regions compared to those in the parental pR5 strain.
Analysis of all tumors showed that EGFR expression was constantly ( @percent@ ) associated with high p53 nuclear accumulation and Bcl-2 expression in LMP1-positive tissues.
Analysis of alternate resource measures suggests a threshold of LLTCOP size , under which program effectiveness may be lower.
Analysis of bioenergetic profile indicated that aging cells have lower resting oxidative phosphorylation and reduced reserve capacity.
Analysis of carbonylated proteins by ELISA , immunofluorescent imaging , near infrared fluorescence detection , and gel-free proteomic approaches are also discussed where appropriate.
Analysis of CD33 isoforms identified a common isoform lacking exon @number@ ( D2-CD33 ) .
Analysis of collagen images also showed a dependence of the treatment effectiveness with age but with controversial results.
Analysis of covariance ( ANCOVA ) and linear regression were used for statistical analysis.
Analysis of covariance ( ANCOVA ) shows statistically significant effects of age , race , and education on RSAT Speed measures.
Analysis of covariance indicated that the DPSI data were influenced significantly by bowling experience regardless of age group.
Analysis of covariance models were used to investigate the association between biomarker measures and the composite cognitive scores.
Analysis of covariance showed that the significant between group differences in final foot placement error could be accounted for by differences in saccadic response times.
Analysis of covariance was used for multivariate analyses.
Analysis of covariance was used to compare changes in Image of Aging subscale scores from pre- to posttest.
Analysis of covariance was used to compare treatment groups.
Analysis of covariance was used to determine the necessary weight change over @number@ years for a significant alteration of a risk factor.
Analysis of dropout rates by medication use revealed no evidence of selection bias.
Analysis of DVS isotherms provided a quantitative measure of adsorbed and absorbed water vapor consistent with the Raman results.
Analysis of enzymatic activities showed that sirtinol inhibited HNE activity in a concentration-dependent manner.
Analysis of episodic memory in control subjects did not identify associations with rs17070145 , though other SNPs showed significant associations in @number@ series.
Analysis of established type @number@ diabetes risk loci revealed a striking clustering of distinct homeobox TFBS.
Analysis of fecal proteins revealed a reduced trypsin amount in the 5xFAD model mice as compared to the wild type.
Analysis of incident CVD was restricted to @number@ participants without prevalent CVD at baseline.
Analysis of individual dermatomes revealed no significant differences in thoracic dermatomes between genders or age groups , contrary to the limb dermatomes.
Analysis of individual patterns of activation substantiated this impression.
Analysis of influencing factors was also undertaken.
Analysis of KIR genotype revealed that KIR2DL5 and KIR2DS3 were significantly associated with old age.
Analysis of longitudinal data requires approaches that account for inevitable missing data.
Analysis of medical records of outpatients with established diagnosis of COPD was retrospectively performed.
Analysis of @number@ cancer genomes uncovered several pan-cancer candidate genes , including IRS4 , SMARCA1 and TERT.
Analysis of oxidized lipids in isolated HDL and LDL ( oxLDLlipids ) was based on the determination of conjugated dienes.
Analysis of platelet counts across classes of age revealed that platelet number decreased progressively with aging.
Analysis of pre-and post treatment images was conducted by three uninvolved physicians experienced with the Fitzpatrick Wrinkle and Elastosis Scale.
Analysis of predicted targets of miR-181 identified c-Fos and SIRT-1 , proteins critically involved in memory formation.
Analysis of pup weights and metabolic parameters showed no evidence for malnutrition in the MSEW pups.
Analysis of radical prostatectomy tissue samples and benign and malignant prostate epithelial cell lines identified Nox5 as an abundantly expressed Nox isoform.
Analysis of red-edge excitation shift method showed that the red-shift for gHSA ( FRC ) is higher than for HSA.
Analysis of Rhox5-null male mice indicated that at least nine of these are Rhox5-regulated in the testes in vivo.
Analysis of risk factors demonstrated that age was the major factor associated with the development of pelvic floor dysfunction.
Analysis of short-term heart rate variability ( HRV ) may provide useful information about autonomic nervous control of heart rate recovery.
Analysis of stabilometry data also showed a significant improvement in balance for those in the GrHu group , which was independent of age or gender.
Analysis of the adhesives revealed that the Duo-Link cement resulted in significantly lower crown retention ( P < .05 ) than the other @number@ cements.
Analysis of the CARS2 messenger RNA showed that the presence of the mutation resulted in removal of exon @number@
Analysis of the chromosome @number@ locus , revealed strong association in the London FTLD cohort and the Manchester FTLD + ALS cases.
Analysis of the collagen image histogram parameters demonstrated decreasing mean pixel value and increasing full width at half maximum ( FWHM ) with increasing age.
Analysis of the data confirmed the noninferiority of incobotulinumtoxinA.
Analysis of the data using time-varying Cox's regression model to update aspirin intake over time showed similar results.
Analysis of the data was undertaken using thematic content analysis.
Analysis of the discontinuity in ID-AT relation showed that young participants switched from the co-variation to the dissociation pattern as ID increased.
Analysis of the expression of MAPT isoforms further revealed altered splicing and representation of tau isoforms involving exons @number@ @number@ and @number@
Analysis of the hierarchical clustering of the amino acid profiles clearly distinguished severe ocular surface diseases from non-ocular surface diseases.
Analysis of the individual metabolic syndrome factors , however , revealed an inverse association between the level of glucose and cognitive performance.
Analysis of the literature supports systemic roles for genes for these SNPs beyond those related to lipid metabolism.
Analysis of the mechanism of action of enhancer substances.
Analysis of the mice revealed both cooperative and independent effects of Aβ and p-tau.
Analysis of these results strongly supports the non-inferiority of NTC to onabotulinumtoxin A in the efficacy and safety.
Analysis of the time duration shows that data should be collected for at least @number@ min.
Analysis of the Timing Hypothesis in women examined in the Women's Health Initiative primarily used chronologic age to assess divergent effects of estrogen.
Analysis of this data allows the cells from adenomyosis characterized physiological stability in culture and karyotypic instability with non-random involvement certain chromosomal set.
Analysis of tissues from these mouse models revealed that the damaging effect of these proteins on mitochondrial function is time- and dose-dependent.
Analysis of uteri from Pten heterozygous and Pten overexpressing mice further confirmed that over-activation of mTOR signaling leads to endometrial hyperplasia.
Analysis of variance and a multinomial logistic regression analysis adjusting for covariates were used to assess the differences between groups.
Analysis of variance and block-wise regression analyses were conducted.
Analysis of variance and Kruskal-Wallis tests to examine differences between groups and multiple regression analyses to identify factors associated to health and well-being were performed.
Analysis of variance and Pearson or Spearman correlation coefficients were used to examine correlations between sociodemographic and health characteristics and social engagement.
Analysis of variance and Tukey honestly significant difference tests compared clinical characteristics among these subgroups.
Analysis of variance ( ANOVA ) followed by post hoc analysis ( Dunnett T3 ) was used for statistical purposes.
Analysis of variance did not confirm the \ "sensory enhancement \ " hypothesis , but provided evidence for the \ "sensory suppression \ " hypothesis.
Analysis of Variance models using Bonferroni corrections determined between and within group differences in these gait features ( α = 0.05 ) .
Analysis of variance provided significant differences among the samples as a function of the type of vinegar , aging time and raw material.
Analysis of variance was used to estimate geometric means adjusted for study and relevant covariates.
Analysis of variance was used to explore differences among groups for outcome measures.
Analysis of young versus older DCreg following culture revealed no differences in phenotype.
Analysis of β-amyloid deposits , tau phosphorylation , and inflammatory cells revealed that , overall , pathologic findings were unchanged.
Analysis on individual frequency sub-bands demonstrated that different sub-bands contribute differently to classification , providing extra evidence regarding frequency-specific distribution of BOLD signals.
Analysis pipelines for promoter analysis and protein-ligand docking were developed.
ANALYSIS : Psychometric validity and reliability of the Self-Report HABC Monitor.
Analysis revealed improvement ( downgrade of at least @number@ score ) in almost all subjects.
Analysis revealed that aerobic endurance and lower body strength decline over time.
Analysis showed that physical and mental health were consistently and significantly associated with satisfaction in each of the domains after adjusting for potential confounders.
Analysis techniques included general linear mixed models examining trajectories of functional change predicted by lesion volume at baseline.
ANALYSIS : The number of falls will be analyzed using a Poisson mixed model.
Analysis using initial coding followed by comparison of data with a pre-existing framework concerning deception in clinical practice.
Analysis was based on grounded theory and dyadic analysis principles adapted to families.
Analysis was based on @number@ elderly people aged @number@ and over from the general Polish population who participated in the COURAGE in Europe project.
Analysis was by modified intention to treat ( all participants with at least one post-baseline observation ) .
Analysis was conducted on @number@ swimming event participants , taking account of respective swimmer birth dates and the Fédération Internationale de Natation points gained.
Analysis was conducted using thematic analysis.
Analysis was conducted using time to event Cox Regression for recurrent events.
Analysis was performed on the sustained vowels / i : / and / a : / at three target levels for both pitch and loudness.
Analysis was performed with a high-performance liquid chromatographic system with a fluorescence detector.
Analysis was then performed using a MALDI-MS / MS-based approach combined with nano liquid chromatography.
Analysis with Mantel-Haenszel odds ratios and mixed-effects logistic regression models accounted for matching.
ANALYTICAL APPROACH : Thematic synthesis was used to analyze the findings.
Analytical methods that can help to identify new activity of sirtuins and new acyl lysine modifications are thus needed.
ANALYTICAL PROCEDURES : Encrustations were submitted to chemical-mineralogical analysis as well as to their quantification.
Analytical studies with larger samples are needed to understand the reasons for such reductions.
Analytic strategies examining this and other risk factors across the lifespan may affect interpretation of results.
Analytic strategies for longitudinal analyses are provided.
Analyzed from a biomedical and philosophical point of view , this phenomenon is also a potential risk factor for social sustainability of communities.
Analyzing data from @number@ respondents to a randomly distributed questionnaire , this article focuses on the motivational importance of social norms.
Analyzing individual pulses ( total of @number@ readings ) showed a significant decrease in impedance during the pulse.
Analyzing long-term trends requires to discern independent effects of age , period , and cohort using APC analysis.
Analyzing the effect of APP and its γ-secretase-derived cleavage products Aβ and AICD on PGC-1α expression showed that APP and AICD increase PGC-1α expression.
Analyzing these properties can help in understanding the phenomenon of facial aging and incorporating the findings can help in designing effective algorithms.
Analyzing this trajectory is crucial for understanding biological and sociocultural processes that determine the span of life.
An amalgam of health concerns differentially affects the behavioral , psychological , and physical well-being of African American women.
Anamnesis and the level of social adaptation were also assayed.
An amplifying trend of the association with age was observed in the total sample ( p = @number@ ) .
An anabolic state may be achievable following eccentric exercise , while improvements to insulin sensitivity have not been found.
An analogous association with SDM did not hold for verbal ability.
An analysis and discussion are then provided to validate the feasibility of CI-device implementation for activity supervision in the elderly.
An analysis of covariance revealed that muscle EI values remained different ( p < @number@ ) between age groups after adjustment for differences in PA.
An analysis of radiological density discovered significantly high values.
An analysis of serum testosterone seems to be essential.
An analysis of the centre of pressure ( COP ) displacement during standing position was therefore performed for the three groups of subjects.
An analysis of the children's errors also revealed complex interactions between these factors.
An analysis of the children's errors also revealed complex interactions between these factors.
An analysis of the four groups prior to training indicated no significant differences between the groups.
An analysis of Young's modulus showed that the vertebral bodies become more fragile.
An analysis was conducted into death locations in Londrina in Mortality Information System ( SIM ) considering the main causes and locations of death.
An analysis with cyclic voltammetry on the purified protein showed that this structural modification severely reduces the ability of the protein to store iron.
An analytic exemplar for each model was provided.
Anandamide is an endocannabinoid involved in several physiological functions including neuroprotection.
Anandamide is synthesized on demand and its endogenous level is regulated through its degradation , where fatty acid amide hydrolase plays a major role.
An androgenic internal milieu is associated with lesser carotid distensibility and diameter remodeling in women , but the opposite is true for men.
An animal's size is central to its ecology , yet remarkably little is known about the selective pressures that drive this trait.
An anterior-to-posterior tau load ratio in the frontal cortex in preclinical cases was 12-fold greater than in end-stage corticobasal degeneration cases.
An anticlockwise deviation of the subjective vertical was observed in the neglect group whatever the experimental conditions.
An anti-inflammatory haplotype with a population frequency of @percent@ was associated with lower handgrip strength ( P = @number@ ) .
An antithrombogenicity test was performed by dropping blood onto the hybrid material surface.
An APC model indicated a reversal increasing period effect , which increased prominently from @number@ to @number@ in both males and females.
An APC model with Møller's power-link function was utilized to predict the incidence of mesothelioma.
Anaphylaxis is the most severe type of food allergy.
An App ( Android and iOS ) is available in @number@ countries and @number@ languages.
An apparently inevitable consequence of oncogene activation is the generation of DNA replication stress ( RS ) , a feature common to most cancer cells.
An application of agents which suppress the activated ET-NADPH oxidase in the vascular wall is beneficial to attenuate vascular abnormalities.
An APP mutant lacking all C-terminal lysines underwent the most pronounced increase in processing , leading to accumulation of both secreted and intracellular Aβ40.
An appreciation of perioral anatomy as well as the structural characteristics that define the aging face is critical to achieve optimal patient outcomes.
An approach to continue updating the framework with the help of experts was piloted.
An approach to integrating non-pharmacologic and pharmacologic treatments is described.
An approach to vertically supporting the lower eyelid is presented.
An appropriate control of the glucose levels and a diet rich in antioxidant agents are recommended in patients with diabetes.
An area of intense research interest is the role and indeed the fate of autophagy during cellular and organismal ageing.
An areolar tissue plane was found between the skin and adjacent medial crura.
A narrative framework is suggested as a useful basis on which to understand the work of managing appearance over the life course.
A narrative framework is valuable in showing that quality of life is a dimension of meaning associated with maintaining a sense of social worth.
A narrative synthesis of all studies will be presented by type of outcome ( social isolation or loneliness ) and type of intervention.
An array of health behaviors and conditions were assessed.
An aspect of crucial importance is the aggregation state of Aβ peptide and its role in neuropathology.
An assessment of quality was conducted for all studies , using the Cochrane tool for assessing the risk of bias.
An assessment was made before treatment , immediately after treatment , and @number@ @number@ and @number@ months after the treatment.
An associated atheromatous disease may be the underlying reason for APT prescription.
An association between advanced age and increased activation in the right middle frontal region was observed during the incongruent ST.
An association between Hsp70 @number@ A / G SNP and zinc plasma levels was observed in the dominant model.
An association between insulin resistance and left cardiac changes was found , although its mechanism remains to be determined.
An association between lower FA values and higher cholesterol levels were identified in different brain regions from those associated with systolic blood pressure.
An association between osteoporosis and periodontitis was only confirmed in women.
An association between poor oral health and an increased risk of ischaemic stroke has been recognised through the oral infection-inflammation pathway.
An association between prenatal air pollution exposure and telomere length at birth could provide new insights in the environmental influence on molecular longevity.
An association between progression of cervical disc degeneration and that of lumbar disc degeneration has been considered to exist.
An association between the increasing cholesterol and greater thickness in frontoparietal and occipital areas was also noted.
An association has been reported between PD and exposure to mitochondrial toxins , including environmental pesticides paraquat , maneb , and rotenone.
An association of structural as well as functional brain network characteristics with intelligence has already been reported in young adults.
An association of the partial portion of cellular CD147 to γ-secretase further supports the functional relation to AD pathology.
An association was found between race and self-reported stress though not statistically significant.
An association with mortality was made.
An association with the female partner's tendency to reappraise with fewer symptoms in the male partner at risk for adjustment disorder could also be observed.
An association with the presence of these reflexes and the development of aspiration pneumonia during @number@ months was also confirmed.
Anastomotic leak following colorectal surgery can be a devastating adverse event.
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A National Council of Youth Sports survey found that @number@ million children aged @number@ to @number@ yr participate in some form of organized athletics.
A nationally agreed set of quality standards would help fulfil this need for UK memory services.
A national men's health policy based on a male-friendly approach to health-care delivery is urgently needed to provide a framework for addressing these challenges.
A national population-based cross-sectional study with a sample of @number@ aged @number@ years or older in South Africa was conducted in @number@
A national survey was distributed to each State Unit on Aging , all but three states participated.
A nationwide colorectal cancer screening program should be designed and implemented to increase early detection and improve survival outcomes.
A nationwide multicenter survey gathering information on surgically treated ASD patients was conducted by the committee for Adult Spinal Deformity of the Japanese Scoliosis Society.
Anatomical and functional improvements in IVIG-treated pups correlated with decreased deposition of C3b complement fragments in the injured brain hemisphere.
Anatomical and physiological changes related to the aging process make people vulnerable to physical and cognitive impairments.
Anatomical correspondence of MTA and PA was assessed using manually-delineated regions of the hippocampus and posterior cingulate gyrus , respectively.
Anatomical details of axillary vascular anatomy and its variations have been evaluated , described and stored in a prospective database.
Anatomically , degenerative lumbar spinal stenosis can involve the central canal , foramina , and lateral recess.
Anatomically , skeletal muscle and bone are closely related.
Anatomical observations and histologic examination were used to describe the age-related changes in this area.
Anatomical relationship between SSS and sagittal suture was analyzed.
Anatomic and effective SP lengths were longer for specimens from white individuals.
Anatomic findings showed the existence of distinct superficial and deep fat compartments.
An atomic force microscope technique was used for tensile testing of individual collagen fibrils.
Anatomic locations treated included face , chest , arms , and legs.
Anatomic studies demonstrate that there are also many changes to the craniofacial skeleton as patients age.
Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD.
Anatomy , anatomical changes with aging , techniques of rejuvenation and facial harmonization with fillers are reviewed.
An attempt is made here to provide rational explanations for these puzzles.
A natural aging model was constructed and used in these experiments.
A natural killer ( NK ) cell degranulation assay is often used to screen for FHL3 patients.
A naturally occurring polymorphism caused a six-fold change in gene transcription and a @percent@ change in lifespan.
Anautomated analysis for 18F-FDG-PET was also performed to calculate the PET score.
An automated method was used to calculate sulcal widths and hippocampal volumes ( HV ) .
An automated software will extract relevant data from the same electronic chart system at all centres , thereby minimizing data treatment and human intervention.
An automatic imaging system is used to capture the outline of the lens , while it is rotating , at pre-determined angular orientations.
An autophagy inhibitor reduced autophagy , increased the S-phase fraction , and attenuated the inhibition of cell proliferation induced by WT p53.
An autopsy case of Hirayama disease revealed confined necrosis of the cervical anterior horn without obvious changes in the white matter.
An available model portraying lens growth could be advantageous in many practical applications.
An average decrease in cell size of 56±16% resulted.
An average of three sessions per week over a period of six to eight weeks before surgery seemed a good compromise between feasibility and effectiveness.
ANCA-associated vasculitis affects more than @number@ per million of the population per year and prevails in the elderly.
ANCA-related HP is the most frequent form , followed by IgG4 / MFS-related HP.
Ancestry informative markers were used to estimate individual percent EA.
Anchored in theoretical concepts of filial responsibility and equity , this article is an in-depth examination of tensions between caregiving siblings in two families.
Anchoring vignettes offer a relatively uncomplicated and cost-effective way of identifying and correcting for reporting heterogeneity to improve comparative validity of self-report measures of health.
Ancillary procedures have also been included when indicated.
Ancillary tests , especially yeast culture with speciation , are frequently crucial to obtaining a correct diagnosis.
ANCOVA models were used to assess the association between adherence to the MedDiet and cognitive decline.
ANCOVA revealed statistically significant differences on semantic clustering ratios ( p < @number@ ) .
ANCOVA was used to analyze whether between-cohort differences in demographic-clinical variables explained between-cohort differences in hippocampal volume.
And a lower GNRI at baseline was associated with increased future medication costs and worse health in hemodialysis patients.
And also elaborate the interaction of FOXO with the nucleosome remodelling complex to target genes , which is essential to cellular homeostasis.
And angiotensin-converting enzyme inhibitors ( ACEIs ) have been shown to improve exercise capacity in elderly without heart failure.
And are age-related declines in ProM smaller than age-related declines in retrospective memory ?
And at @number@ days , a mean @number@ mm submental lift was noted ( p = @number@ ) .
And at the end of life , music therapy has found a remarkable place for expressing or supporting strong emotional feelings.
And BDR was measured with a DXA fan-beam bone densitometer at various skeletal regions including lumbar spine , left hip and left forearm.
Andersen's Behavioral Model provided the conceptual framework to identify other potential predictors of admission.
And finally and perhaps most importantly , how did the expansion spread throughout Europe ?
And further , how do older listeners deal with acoustic and predictive information ?
And have institutionalization rates fallen regardless of disability level , or has LTC use become better tailored to needs ?
And how rapamycin , at rational doses and schedules , may prevent IR , retinopathy , nephropathy and beta-cell failure , without causing side effects.
And if so , how should we make sense of this work and what significance should we attach to it ?
And , in a validation study CSHA-2 stroke-free subjects were followed to CSHA-3 to see if the prospective analyses findings could be replicated.
And increasing evidence suggests that hypocretin cells in the lateral hypothalamus may provide particularly important contributions.
And intervention is not strictly consistent.
And is this even safe ?
And it had no relationship with the brachial artery pressure ( P > @number@ ) .
And it is also the first time that a betaenone-type compound was isolated from the genus Lecanicillium.
And it was elder than that of those with a low AIX ( @number@ y ± @number@ y , P = @number@ ) .
And many questions are related to the treatment of growth failure.
And more distressingly , most patients eventually develop acquired resistance after an initial response to PD-1 / PD-L1 blockade.
And now , there is mounting literature implicating Rho-GTPase signaling in AD pathogenesis as well.
And pre-diabetics had somewhat similar prevalence of @time@ % and slightly higher incidence of @percent@ for frailty than non-diabetic older adults.
And , presbycusis , cataracts , cerebrovascular disease , osteoarthritis , and unclassified injuries should be the priorities in ameliorating disability.
And rapidly activating delayed rectifier potassium currents were tested in hERG-HEK293 cells.
And regulatory networks of targets were built based on the target pairs.
Androgen ablation therapy is the primary treatment for metastatic prostate cancer.
Androgen and estrogen can rapidly modulate synaptic plasticity of neural circuits.
Androgen and estrogen deprivation , as well as some forms of cytotoxic chemotherapy , may lead to osteopenia and osteoporosis.
Androgen deprivation therapy is associated with an increased incidence of diabetes and cardiovascular disease.
Androgen-deprivation therapy significantly decreased all @number@ ST segments in both leads.
Androgenic deficiency regressed in groups @number@ and @number@ but enhanced in group @number@ ( p = @number@ ) .
Androgen is synthesized in the adrenal gland and the ovary.
Androgen may exert complex effects on the vessel wall.
Androgen receptor ( AR ) reactivity was similar among all groups.
Androgen receptor ( AR ) signaling has been implicated in bladder cancer as well as other types of cancer including prostate cancer.
Androgen receptor ( AR ) signaling is essential for the development of prostate cancer.
Androgen receptors ( ARs ) are found in many tissues.
Androgens act as anabolic agents regulating muscle mass and improving muscle performance.
Androgens exert different actions on organs like adipose tissue , brain , bone , and on cardiovascular system.
Androgens have beneficial effects on endothelial cells and smooth-muscle cells.
Androgens have potent anabolic effects on skeletal muscle and decline with age in parallel to losses in muscle mass and strength.
Androgen signaling occurs primarily via the androgen receptor.
Androgens play a crucial role in bone , muscle and fat metabolism , erythropoiesis and cognitive health.
Androgens play a primary role in female physiopathology.
Androgens regulate fat mass and glucose homeostasis , but the effect of androgenic hormones on skeletal muscle fat infiltration is largely unknown.
Androgens , the levels of which decrease with ageing , play many physiological roles in various organs.
Androgen treatment stimulates proliferation of 104-S cells , but causes growth inhibition and G1 cell cycle arrest in 104-R1 and 104-R2 cells.
Andrographolide induced the gene expression of heme oxygenase @number@ ( HO-1 ) and glutamate cysteine ligase modifier subunit ( GCLM ) in a time-dependent manner.
Andrographolide , the major bioactive component of Andrographis paniculata , has been demonstrated to have various biological properties including anti-inflammation , antioxidation , and anti-hepatotoxicity.
Androgyny model suggests that those with high levels of both masculinity and femininity ( androgynous ) are more adaptive and hence have better health.
Androgyny was measured by three approaches : geometric mean , t-ratio , and traditional four-gender groups classification.
And SNs were observed more frequently in males than females ( @percent@ vs @percent@ ) ( P < @number@ ) .
And the age-adjusted incidence rate was @number@.84 / 100 @number@ in @number@
And the androgen receptors of peripheral lymphocytes were assessed by flow cytometry.
And the best surgical strategy will depend on the clinicians ' surgical techniques and patients ' characteristics.
And the control cosmetic make-up subjects on average projected a @percent@ better first impression than subjects wearing no make-up.
And the Evidence for Policy and Practice Information and Co-ordinating Centre ( EPPI-Centre ) three-stage approach to mixed method research was used to synthesise data.
And their tumors were not relapsed.
And the Join point @number@ software was used to analyze secular trends.
And the knowledge of the drug resistance conferred by miR-33b-3p has great clinical implications for improving the efficacy of chemotherapies for treating lung cancers.
And then in LMP1-negative samples , we detected the EBV-encoded RNA ( EBER ) using in situ hybridization.
And then patient's oral intake was stopped , intravenous fluid and ceftriaxone @number@ g / day were started.
And then the 2-month-old HIF-1alpha gene knock out mice were randomly divided into Yiqi Huayu prescription group and physiological saline group.
And then the effect of different compatibility of acupoints was observed.
And then , the system notifies the caretakers about the adequacy of the type , quantity , and timing.
And the occurrence of SNs is positively associated with lumbar disc degeneration.
And the prevalence of dry eye increases following the aging process.
And the reduced masseter prominence and prominent chin were obtained , showing a favorable facial contour and harmonious appearance during the follow-up.
And there is concordance around the leadership best suited to lead innovation.
And the relative SIs ( RSIs ) were assessed by comparing with cerebrospinal fluid.
And there was a @percent@ reduction in the MMBF value of the workers from age of @number@ to @number@
And the third sample was got after @percent@ NaCl quick rinse.
And the tissue solutions were cultured.
And urocortin2 caused reduction of rapidly activating delayed rectifier potassium currents in hERG-HEK293 cells.
And we implemented a middle ware using Multi-Agent platform in SOS ( Self-Organizing System ) platform that transmits patient clinical data for services.
And we used individuals aged @number@ years or above ( n = 210 , 914 ) .
And what variables must be taken into account for these conversations to proceed successfully ?
And why do we not invest in public awareness campaigns ?
An earlier NC may not be associated with improved 90-day survival.
An earlier peak occurred for 1960s music , which may be explained by its quality or by its transmission through two generations.
A necessary component of the prescribed continuing care act should be the creation of a long-term care insurance program in Canada.
An ecological assessment procedure of RL was employed and landmarks learning and navigational abilities were evaluated.
An ecological framework was used to capture environmental factors , perceptions regarding access to health promotion resources , and health behavior preferences and practices.
An educational media effort to promote the public's understanding of the efficacy of these multiple approaches is needed.
An education gradient in functional limitations exists only for White adults.
A need exists for guidelines that facilitate the design and reporting of flavonoid research.
A need was identified for a similar questionnaire for toddlers ( aged 18-35 months ) .
An EE-set point has been proposed as the width between the upper and lower boundaries of the individual EE range.
An effective algorithm for detecting pupil size based on image processing was established.
An effective diet for prevention of periodontal disease has not been well established.
An effective disease management protocol should be employed to target this patient group.
An effective screening test could significantly impact identification of developmental delays at an early age.
An effort was made to incorporate leisure activity tasks that were more stimulating , and potentially more challenging , into a set of traditional IADLs.
A negative association of sarcopenia with overweight , obesity and lean / fat mass ratio was observed.
A negative change means a worse adjusted average adherence to process indicators.
A negative correlation between age and cell expression of ICAM-1 , CD25 and IL-10 was observed in a group of healthy donors.
A negative correlation between CD29 and CD45RA ( p < 0.05 ) was observed.
A negative correlation between patient's age at assessment and perceived physical appearance existed ( r = -0.53 ; p < 0.05 ) .
A negative correlation was detected in the lower ROI of the oldest group.
A negative correlation was found between age and distensibility of the lower labial mucosa.
A negative correlation was found between emotional enhancement effect and the memory performance related to \ "know \ " responses.
A negative correlation was found for grade III carcinomas and triple-negative cases.
A negative correlation was observed between age and moisture content of the lower labial mucosa.
A negative fluid balance predicts survival.
An electrogoniometer was used to measure the range of movement.
An electronic journal search was undertaken to identify all the relevant studies published in English.
An electronic search based on Internet search engines , MEDLINE ( @date@ @number@ ) and the Cochrane Controlled Clinical Trials Register was done.
An elevated jugular venous pressure is the most reliable clinical sign of fluid volume overload and should be carefully evaluated.
An elevated PI3K / AKT / mTOR activation state conferred sensitivity or resistance , depending on the applied inhibitor.
An elevated serum anion gap is known to be associated with hypertension , low cardiorespiratory fitness , and decreased renal function.
An elevation in capecitabine Cmax and reduction in clearance was seen in females , where capecitabine AUC was @percent@ higher in women.
An ELISA kit was used to measure both the plasma and salivary lipofuscin levels.
An embedded process evaluation will obtain information to test out the theory of change underpinning the intervention and its acceptability to staff and residents.
An emergent issue , however , is generating an increasingly wide debate.
An emerging aspect of neuronal-glial interactions is the connection glial cells have to synapses.
An emerging theme in field is that many transcribed genes are potential targets of AID , presenting an obvious danger to genomic integrity.
Anemia can be related to decreased production or increased loss of erythrocytes , or both , leading to many underlying and often overlapping causes.
Anemia is a common feature of HIV-related disease and has been uniformly demonstrated to be an independent predictor of morbidity and mortality.
Anemia is a frequent disease in elderly persons , but is often undertreated and misunderstood as a physiologic consequence of aging.
Anemia is also a common feature of normal aging.
Anemia is an independent predictor of these adverse outcomes both in healthy community-dwelling subjects and in patients with significant co-morbidities.
Anemia is a significant problem in elderly patients.
Anemia is associated with increased risk of mortality , functional dependence , dementia , falls , and chemotherapy-related toxicity.
Anemia was defined as a hemoglobin levels < 13.0 g / dL.
An empirical equation has been proposed to localize minima of the RTD function and to predict Per .
An emulgel formulation containing @number@ % green tea extract and @number@ % rose oil was designed as a result of pre-formulation studies.
An endless number of career trajectories are possible for gerontologists.
An endothelial dysfunction generates a proatherogenic environment characterized by stimulating thrombus formation.
An enhanced modulatory effect on both cholinergic and catecholaminergic transmissions was observed on @number@ day fed mice.
An enhanced understanding of how normal aging alters brain structure is urgently needed for the early diagnosis and treatment of age-related mental diseases.
An enriched feature set , including values derived from Quantitative Production Analysis ( QPA ) may shed further light on this little understood distinction.
An ensembled artificial neural networks ( EANN ) prediction model was established and seven different methods for assessing variables importance were applied.
An enzyme involved in LXA4 synthesis and two SPM receptors were elevated in AD brains.
An enzyme which synthesizes it , prostaglandin D2 synthase ( PTGDS or lipocalin-PGDS ) , is hormone responsive in multiple other organs.
An ESCEO-EUGMS ( European Union Geriatric Medicine Society ) working group has recently suggested possible patient profiles in OA.
A nested case-control study of white women @number@ years of age and older enrolled in the Study of Osteoporotic Fractures ( SOF ) was performed.
ANESTHESIA : Fractional laser treatment can be carried out under topical anesthesia with eutectic mixture of lidocaine and prilocaine.
Anesthesia-related postoperative cognitive dysfunction ( POCD ) leads to morbidity in the elderly.
ANESTHESIA : These lasers are mostly pain-free and tolerated well by patients but may require topical anesthesia.
Anesthesia was achieved by @percent@ lidocaine cream and a cold air chiller.
Anesthetic agents influence the microcirculation of a combination of effects on cardiac output , arterial pressure , and local microvascular changes.
Anesthetic time was a statistically significant predictor of postoperative medical complications ( odds ratio @number@ @percent@ confidence interval @number@.117-1.663 , P = @number@ ) .
An estimated @number@ deaths in Americans aged @number@ years and older were attributable to AD dementia in @number@
An estimated @number@ million Americans had Alzheimer's disease in @number@
An estimated @number@ million injuries occur within the USA each year and @number@ million people are affected annually worldwide.
An estimated @number@ million people in the USA may have been infected to date.
An estimated @number@ % of total energy and @number@ % of total fat from other food sources was displaced.
An estimated @number@ ( SE , @number@ ) individuals per @number@ person-years progressed from CIND to dementia.
An estimated sample size of @number@ people was chosen using systematic random sampling and the cluster method.
An etiologically heterogenic group of disorders related to aging as well as genetic and environmental interactions probably underlie the impairment in Alzheimer's disease.
A network approach to care permits both quantitative and qualitative study , and the approach can be used to explore many important questions.
Aneuploidy , a chromosome content that deviates from a diploid genome , is a recognized form of genomic instability.
Aneuploidy rate in the patient group was significantly higher than the general population group.
A neural model shows that these bandwidths increase by a factor of @number@ between age @number@ and age @number@ years.
A neuro-inflammatory response has been implicated in human patients and animal models of Alzheimer's disease ( AD ) .
A neurologist reviewed provider-linked medical records to identify prevalent dementia ( review date = index ) .
A neuropsychological assessment was administered in @number@ stable COPD patients and @number@ non-COPD controls with comparable smoking status , age , and level of education.
A neuropsychological battery was administered to @number@ Greek-Cypriot older adults.
A neuropsychological battery was used to assess cognitive performance and determine the Clinical Dementia Rating Sum of Boxes ( CDRSOB ) .
A neuropsychological test battery was used to assess cognition.
A neuroradiological evaluation of the intracranial circulation might therefore be considered in the diagnostic work-up of patients affected with acromegaly.
Aneurysm can develop in all arteries of the human body.
Aneurysms are characterized by structural deterioration of the vascular wall leading to progressive dilatation and , potentially , rupture of the aorta.
An evaluation indicated that training significantly improved knowledge and that trainees were highly satisfied with the training.
An evaluation of immunocompetence before therapy may help to predict therapeutic success and guide the selection of appropriate regimens.
An evaluation of @number@ patients who participated in this group intervention showed a significant improvement of depression , psychosocial burdens and somatization.
An evaluation of the methodological quality was performed.
An even higher percentage would want friends to initiate the topic.
An evidence-based best practice was developed to improve the quality of care for older patients.
An evidence-based protocol known as individualized music ( IM ) offers a non-pharmacological intervention to reduce agitation.
An evolutionary conserved response of cells to proteotoxic stress is the organized sequestration of misfolded proteins into subcellular deposition sites.
An evolutionary rationale suggests that genetic trade-offs should not be an exception in studies of aging-related traits.
A new ' ' ( AIM ) framework may help to clarify how affective and motivational circuits support decision making.
A new approach using magnetic resonance imaging has recently been described and may ultimately enable glomerular imaging and quantification in vivo.
A new arterial distensibility measurement technique was assessed in @number@ healthy normotensive subjects.
A new ascorbic acid ( AA ) nanocomposite with low toxicity and high photo and thermal stability is constructed for certain dermatological applications in humans.
A new body of work has emerged under the category of creating age-friendly communities.
A new clinical and cost effective models of practice would be needed as well as the different models of personnel training.
A new , comprehensive classification system distinguishes four categories of instability.
A new concept related to illness is Chronodisruption ( CD ) .
A new enthesis was clearly produced in cell-injected G2 and G3 rats , but not in the controls.
A new family of innate sensors is the family of TREM ( triggering receptor expressed on myeloid cell ) .
A new finding is that the rat SCN contains some local cholinergic neurons.
A new formulation of BoNTA ( abobotulinumtoxinA , Dysport™ ) has recently been approved in the U.S. for the treatment of glabellar lines.
A new framework is proposed for the interpretation of spontaneous cardiac baroreflex sensitivity data and the general concept of baroreflex resetting.
A new home-use RF device for facial treatments has recently been developed based on TriPollar™ technology.
A new initiative is recommended comprising collaboration between regulators , colleges and employing institutions to support the ageing doctor in providing safe and effective practice.
A new lead compound ( acetamide @number@ ) has been discovered to efficiently stimulate adult rats ' neurogenesis.
A newly designed insulated microneedle system delivers a signi cant coagulative thermal injury into the dermis while sparing the epidermis from RF injury.
A new method based on weighted ICV matching is also presented.
A new method of eye-care delivery that mitigates distance barriers and improves access was developed to improve screening for potentially blinding conditions.
A new methodology was presented and consisted of quantifying blood volumes.
A new method to determine the \ "pseudo-static \ " contact angle on hair was developed.
A new model of breast tumor spheroid killing by human PBMCs was developed.
A new , noncanonical role for Stat3 in mitochondrial function has been discovered recently.
A new pair of shoes was provided to each participant at an inclusion visit.
A new physiological index ( μ ( PA ) ) is proposed to represent the autonomic nervous system ( ANS ) function.
A new predictive model for grade 3-5 chemotherapy toxicities was developed by Hurria et al.
A new promising approach is reversal of corticosteroid resistance through increasing histone deacetylase-2 activity.
A new rejuvenation concept is proposed during our practice ; the Asian face should preserve the original facial identity during Botox treatments.
A new search for updates in the Cochrane Database was launched in @date@ .
A new study identifies rare mutations in SPRTN that cause a novel progeroid syndrome.
A new technique for the measurement of MPOD spatial profiles has been developed by overcoming the current shortcomings associated with the use of visual displays.
A new technique in aesthetic plastic surgery termed \ "myoablation \ " is described.
A new therapeutic strategy consisting of a second IV thrombolysis with low-dose tenecteplase was applied.
An exaggeration of it could be the clinical manifestation of dementia , with intraneuronal accumulation of protein aggregates deranging the metabolic state.
An examination bank was created and used to include test-enhanced education.
An examination of covariates suggested that age effects were associated with age differences in mental health and affective responses rather than demographic or cognitive variables.
An examination of life goals identified by community-dwelling , low-income older adults indicates that functional performance mechanisms are valued.
An example and directions for developing and implementing cognitive prescriptions are described.
An example is observed in humans : women appear to have a slightly higher body temperature and yet live longer than men.
An example is vaccination with antibodies to Aβ , which is effective in mouse models , but has repeatedly failed in clinical trials.
An example of association with positive MOC value was depression score ( MOC @number@ p = @number@ ) .
An example of such a process is cognitive ability , where a decline a few years before death is sometimes observed.
An ex-Gaussian analysis revealed that removing the RTs on error-adjacent trials reduced the length of the tails of distributions and the skewness of the distributions.
An exhaustive literature search , examining the effect of thermal cycling on restorative dental materials , was performed with electronic database and by hand.
An expanded set of BDNF- and GABA-related genes exhibited similar age-related changes in DNAm and correlation with gene expression.
An expansion of a trinucleotide CAG repeat on chromosome @number@ causes Huntington disease.
An expectation of the article is that stronger effects of poor health may be found in young adults compared to middle aged people.
An experimental evaluation of human coronal dentin was performed using nanoscopic dynamic mechanical analysis ( nanoDMA ) .
An experimenter administered all tests and conducted the interviews.
An experiment was designed to investigate the temporal and spatial couplings of the transport and grasp components for bimanual movements performed by children.
An expert consensus panel assigned a diagnosis of normal cognition , CIND , or dementia and its subtypes.
An expert consensus panel measured MCI based on published criteria.
An expert consultant panel was consulted to categorize facility characteristics into domains and determine possible etiologies of APM use based upon each characteristic.
An expert panel rated each vignette as unlikely , possible , or probable delirium and disagreements were resolved by consensus.
An explanation of the high short sleep prevalence among White Africans may be related to their racial or ethnic minority status in South Africa.
An exploratory analysis was performed to assess the strength of associations between hearing loss and individual items of the SIS scale.
An exploratory biomarker analysis was performed using logistic regression.
An exploratory descriptive study was conducted to explore the perspectives of patients who had fallen in the hospital ; @number@ patients were interviewed.
An exploratory factor analysis was also performed.
An exploratory factor analysis was conducted to detect multimorbidity patterns in the population over @number@ years of age.
An exploratory factor analysis with the principal components extraction method and oblimin rotation was performed to evaluate construct validity.
An exploratory multivariate divergence analysis selected task performance and neurophysiological variables that best recognized impairment.
An exploratory post hoc whole-brain analysis also indicated that SCD was predominantly associated with greater tau burden in the entorhinal cortex.
An exponential model describes the time course of the victory percentage with a great similarity for both genders.
An extension of the maximum lifespan and a sizeable extension of life expectancy both require reductions in mortality above the age of @number@ years.
An extensive battery of memory tests was administered on three occasions , each six weeks apart.
An extensive body of evidence indicates that oxidative stress and inflammation play a central role in the degenerative changes of systemic tissues in aging.
An extensive neurologic and neurocognitive examination was performed on @number@ symptomatic individuals and @number@ nonsymptomatic individuals.
An extensive neuropsychological assessment examining memory was administered to each participant.
An extensive proportion of Asp isomerization was observed at all Asp sites of crystallins in the insoluble fraction of aged lens.
An extinction programme alone , although highly effective , is difficult for parents to comply with.
An extra-individual factor , using assistive devices , was significantly related to maintaining older adults ' disability levels , even for those who started disabled.
An eye was considered to have cornea blindness if the visual acuity was < 20 / 400 due to a corneal disease.
An FGF21-resistant state that increases circulating FGF21 has been reported in obese patients.
An FI consisting of @number@ health-related variables was constructed.
Ang- ( 1-7 ) , through its Mas receptor , prevents or diminishes deleterious effects induced by skeletal muscle disease or injury.
Ang2 antibody treatment combines well with low-dose metronomic chemotherapy ( LDMC ) in settings in which maximum-dose chemotherapy does not prove effective.
Ang2 , VEGF , and KDR expression results were highly variable.
Anger expression did not predict higher risk for metabolic syndrome in main effects models , but it moderated the relationship between age and metabolic syndrome.
Angew.
Ang II also stimulates mtROS production , which depresses mitochondrial energy metabolism.
AngII infusion and saline injection ; @number@
AngII infusion and sRAGE injection.
Angina and the number of physical conditions were associated with a higher risk of anxiety.
Angina pectoris frequency and LVEF were not associated with functional decline or change in functional status , after adjusting for covariates and other predictors.
Angiogenesis , activation of metastasis and avoidance of immune destruction are important for cancer progression.
Angiogenesis , a formation of neo-vessels from pre-existing ones , is regulated by the local balance between its stimulators and inhibitors.
Angiogenesis and endothelial tube formation controlled by EPO requires , in part , the activation of TRPV1 receptors in conjunction with Akt and AMPK pathways.
Angiogenesis has been also shown to be critical in improving post-stroke neurological functional recovery.
Angiogenesis is a critical step in tumor growth and metastasis.
Angiogenesis is believed to contribute to the development and progression of these diseases.
Angiogenesis is recognized as one of the principal hallmarks of cancers.
Angiogenesis is required for tumor growth and metastasis , whereas angiogenesis is the major cause of blindness in the adult.
Angiogenesis of the microvasculature is central to the etiology of many diseases including proliferative retinopathy , age-related macular degeneration and cancer.
Angiogenesis study was evaluated in vitro with human microvascular endothelial cells-1 and in vivo with the Matrigel plug angiogenesis assay in mice.
Angiogenesis was also quantified by immunohistochemical detection of CD34-positive capillaries.
Angiogenesis , which was visualized by CD31 and NG2 immunofluorescence stains , also increased in ADSC-treated skin.
Angiogenic gene expression can be partially be improved by hypoxic preconditioning , however the effect is age-dependent.
Angiographically , hyperfluorescent round leakage points confirmed the presence of five saccular RAMs.
Angiographic success was @number@ percent.
Angiopoietin-2 ( Ang2 ) is a vascular destabilizing factor that antagonises normalisation.
Angiopoietins ( angpts ) are known to be important regulators of angiogenesis.
Angiotensin also resulted in an increase in mitoSOX fluorescence indicating stimulation of mitochondrial superoxide.
Angiotensin-converting enzyme inhibitors and aldosterone receptor blockers are frequently effective in reducing the risk of progression of cardiovascular and renal disease.
Angiotensin-converting enzyme inhibitors and statins were used by , respectively , @percent@ and @percent@ of all individuals during their final month of life.
Angiotensin converting-enzyme inhibitors were evaluated only as adjuvant therapy to surgery , and their effect on the rate of recurrence remains debatable.
Angiotensin II has been shown to accelerate osteoporosis through RANKL up-regulation in osteoblast.
Angiotensin II receptor blockers ( ARBs ) have been highlighted as one antihypertensive drug class that may confer greatest benefit.
Angiotensin receptor blocker treatment may blunt the harm associated with high levels of AT1RaAb.
Angiotensin type @number@ receptor blockers ( ARBs ) ameliorate osteoporosis and vascular calcification beyond their blood pressure lowering effects.
Angle measurements were taken in the sagittal plane at each vertebra level from T1 to L5 ; distance measurements were taken from T6 to L5.
Angles in the older male group were @number@ times larger at T1 and @number@ times larger at T7 than in the young male group.
Angpts can also influence inflammation and have been shown to possess both pro-atherosclerotic and atheroprotective effects.
Angular excursions were compared between males and females and between rolling sides , and tested for correlation with isokinetic truncal muscle power.
Angular momentum of the body is a highly controlled quantity signifying stability , therefore , it is essential to understand its regulation during stair descent.
An HA film with an area of @number@ mm × @number@ mm was prepared and polished.
An HS1 practice proceeded to an HS1S2 practice.
An IF5 cDNA was isolated by expression cloning from a mouse oocyte cDNA library.
A. niger , A. tubingensis and A. terreus are rare but stress the need of targeted and adapted antimycotic therapy.
An illustrated story paradigm memory task was used to evaluate the effects of emotional arousal on memory and assess the caregivers ' cognitive compensation capacity.
An image processing algorithm marks the umbilicus and mammary papillae on a digital photograph of the patient's abdomen.
An imagination recombination paradigm was used to elicit AM conjunction errors in young and older adults.
Animal age information can therefore be valuable in ecological research , but many species have no external features that allow age to be reliably determined.
Animal epidemiological and clinical studies suggest that cholesterol is a risk factor for Alzheimer's disease ( AD ) .
Animal models are commonly used in brain ageing research.
Animal models , brain samples from patients , and the development of diverse analytical methods have broadened our understanding of epigenetic regulation in the brain.
Animal models for testing novel regenerative therapies remain the gold standard in pre-clinical phases of drug discovery and development.
Animal models have demonstrated that so called enriched environments protect against neurodegenerative diseases , such as dementia.
Animal models have shown that environmentally induced intrauterine growth restriction increases the risk of a variety of diseases later in life.
Animal models involving dietary omega-3 fatty acid deficiency to deplete brain DHA may therefore not be appropriate in AD research.
Animal models in which components of these signaling pathways are induced or silenced present a general phenotype characterized by the deceleration of the aging process.
Animal models of DM have confirmed the detrimental effect of high blood glucose levels on learning and memory.
Animal models of infectious and chronic disease are important tools with which to dissect the pathways whereby inflammatory responses are initiated and controlled.
Animal models provide excellent insights into conserved mechanisms and key overarching events that bring about endocrine and behavioral aging.
Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a \ "muscle-full \ " state.
Animal models with depleted PINK1 expression have failed to reproduce significant nigral dopaminergic neurodegeneration and clear alpha-synuclein pathology , main characteristics of the disease.
Animal models with strong regenerative capabilities imply that aging processes might not be affecting regeneration.
Animals and plants have biological clocks that help to regulate circadian cycles , seasonal rhythms , growth , development , and sexual maturity.
Animals and plants have biological clocks that help to regulate circadian cycles , seasonal rhythms , growth , development and sexual maturity.
ANIMALS : @number@ randomly selected client-owned cats from @number@ months to @number@ years old.
Animals ranging in age from @number@ weeks to @number@ years were tested with a lateral masking paradigm.
Animals that have successfully passed three consecutive CFR beginning from 19-months of age had longer life span as compared with the control animals group.
Animal studies are also used to propose the physiological mechanisms underlying the cognitive performance improvement associated with exercise.
Animal studies have found evidence of relationships between dietary iron , calorie and cholesterol intake and brain iron accumulation.
Animal studies have pointed to candidate path ways related to ageing , but only a few genes have repeatedly been associated to human lifespan.
Animal studies indicate that there is a net fitness cost in sequestration of telomerase , even when cancer risk is lowered.
Animal studies show a growth response in tendons in response to loading in the immature phase but not after puberty maturation.
Animal studies suggest a differential role of hippocampal subfields in various aspects of navigation , but that hypothesis has not been tested in humans.
Animal studies suggest that perfluorocarbons ( PFCs ) may alter sexual maturation.
Animals were killed on day @number@
Animals were monitored over a 21-month period , and necropsy specimens were collected for histological examination and immunohistochemistry analysis.
Animals were pretreated intravenously with catalytically active rePON1 , followed by exposure to @number@ @date@ LCt₅₀ sarin or soman.
An imbalance between anabolic and catabolic intracellular signaling pathways and an increase in oxidative stress both play important roles in muscle abnormalities.
An imbalance between the antioxidant system and ROS can lead to cell damage , premature skin aging or skin cancer.
An immunocytochemical study was performed at defined end points in order to obtain information about specific cytokines of the microenvironment before and after treatment.
An immunoprecipitation study demonstrated that HSF elastase activity co-immunoprecipitated with anti-NEP in lysates of cultured HSF.
An impairment of GABAergic synaptic inhibition represents a key pathway of epileptogenesis.
An impairment of the PD-L1 / PD1 pathway is present in AD and MCI.
An implication of these newer studies is that ET could be degenerative.
An important and prevalent environmental toxicant that induces nephrotoxic effects is mercury ( Hg ) .
An important area to explore in biomedical sciences is the role of endogenous stem cell niches in joint homeostasis , remodeling , and disease.
An important aspect of study in such system is how the data is treated and processed.
An important challenge in epidemiology is the difficulty in inferring causality from observational studies.
An important clinical question is to identify the mechanisms involved in the age-related defective bone formation.
An important component of ROS signaling pertains to localization and tightly regulated signal transduction events within discrete microenvironments of the cell.
An important component of this approach is the use of spirometry for disease staging , a procedure that can be performed in most older adults.
An important contributor to hospital-associated disability is immobility during hospitalization.
An important cytoprotective enzyme that has been shown to improve renal function is heme-oxygenase ( HO ) .
An important disease control strategy is the prevention of obesity-related hepatic inflammation and tumorigenesis by dietary means.
An important factor is the consumption of a variety of essential elements , in particular vitamins.
An important factor underlying this decline may be the age-related impairment in stimulus-reward processing.
An important finding in the Dutch population is that a pragmatic multidisciplinary fall-prevention programme has no added benefit over and above normal care.
An important finding in this study is the unbalance of the expression of MMP-1 and TIMP-1 along with the growth of the age.
An important gap in the current representational pseudoneglect literature is a discussion of the developmental trajectory of the bias.
An important index for evaluating walking ability is step length.
An important line of postgenomic research seeks to understand how genetic factors can influence epigenetic patterning.
An important line of support comes from the observation that mtDNA deletions accumulate over the life course in post-mitotic cells of many species.
An important outcome of this investigation was the evidence suggesting important air pollution effects regarding CVD risk in South Asia.
An important question for future research concerns the causality of this relationship.
An important question therefore concerns the impact of caring for young children on men's perceptions of their role as grandfathers.
An important question therefore concerns the impact of caring for young children on men's perceptions of their role as grandfathers.
An important result was clustering of significant associations with the strongest effects in the youngest , or 3rd Generation , cohort.
An important role of eIF2αP is the regulation of redox homeostasis and adaptation of cells to oxidative stress.
An important step would be to develop surrogate outcomes to increase efficiency in clinical trials.
An important subtheme that emerged was the connection of community mobility to health care outcomes.
An important trigger for anti- or pro-apoptotic cell responses are different forms of stress including hypoxia , energy deprivation , DNA damage or inflammation.
An improved diagnosis and individualized management is desirable in light of the many available options.
An improved understanding of the basic mechanisms associated with choroidal thinning may guide the development of new therapies for AMD.
An improved understanding of the EC-HSC cross-talk will pave the way for development of EC-directed strategies for improving HSC function during aging.
An improvement in postural stability was observed in all training groups , indicating that even self-administered training could be beneficial.
An improvement in several organisational aspects , including coordination between hospital and rehabilitation services , is warranted.
An inability to suppress the cumulative familiarity of individual AM details appears to contribute to the heightened formation of AM conjunction errors with age.
An inclinometer ( activPAL ) measured the primary outcomes , change in total sitting time and sit-to-stand transitions.
An increased awareness of its impact may alert clinicians to screen for frailty.
An increased awareness of the existence of PTTI should serve to help patients with earlier referral and treatment and by limiting the amount of disability.
An increased cardiovascular risk has to be anticipated in PCOS as it is a metabolically unstable condition.
An increased focus on reducing energy intake resulted in only a modest decrease in salt intake.
An increased number of random pulses removed more epidermis , and with denser pulses per area , a thermal deposit was noted histologically.
An increased QOL was seen , as well as a trend towards less ED visits.
An increased rate of cryptorchidism has been reported in subjects with Down's syndrome.
An increased relative risk of morbidity and mortality with lower serum calcidiol has been shown in almost all the studies.
An increased relative risk of PE was not detected in the very elderly ( relative risk @number@ P = @number@ ) .
An increased risk of developing Alzheimer's disease ( AD ) has previously been found to be associated with variants at the MS4A6A locus.
An increased risk of ISNAs was associated with lacunae and white matter hyperintensity in the parietal region.
An increased risk of thromboembolic complications was also demonstrated in the estrogen only component of the WHI.
An increased tCr / H2O was only observed in the PCC ( P < 0.01 ) .
An increased understanding of age-related neurochemical changes in the GABAergic system will be important in elucidating the underpinnings of the functional changes of aging.
An increase in age in combination with the presence of chronic pain did not additionally affect memory performance.
An increase in AOPP levels indicates an oxidative stress state and the presence of coexisting inflammation.
An increase in basal concentration augmented ambient GABA , increased GABA-mediated inhibitory current , and depressed ongoing-spontaneous activity while still keeping stimulus-evoked activity.
An increase in beta NTP as a function of age ( @percent@ per decade ) approached significance ( p = @number@ ) .
An increase in Cd levels was evident with age.
An increase in density settings results in total ablation of the epidermis.
An increase in DNA content is associated with neuronal degeneration in Alzheimer's disease but has not been evaluated in Lewy body diseases.
An increase in intracuff pressure was noted more frequently and to the greatest degree with head and neck flexion.
An increase in lateralization and a more focussed productive language network have been suggested to be the neural correlates of this process.
An increase in miR-455-3p expression found in AD patients and Aβ pathologies unveiled its biomarker characteristics and a precise role in AD pathogenesis.
An increase in neuronal DNA content was observed in all the affected brain regions examined , although this change was related to different pathologies.
An increase in oxidative DNA damage or decrease in DNA repair capacity with aging or due to germline genetic variation may affect prostate cancer risk.
An increase in Plin2 and a concomitant decrease of Plin5 was also observed when we considered animal model of disuse-induced muscle atrophy.
An increase in septicemia visit rate after @number@ was observed in all age groups.
An increase in Stroop effects with age can be interpreted as reflecting age-related reductions in selective attention , cognitive slowing , or color-vision.
An increase in the expression of iNOS in response to psychological stress was observed in vivo and in cortisol-treated cells.
An increase in the level of endogenous AIMP3 has been observed in aged human tissues and cells.
An increase in the number of skin cancer patients with risk factors for surgery has been predicted because of the progression of the aging society.
An increase in the postprandial d / a was also observed in the elderly subjects who were not undergoing hypertension treatment.
An increase in the reproductive potential and survival is accompanied by a transition from stable to oscillating population numbers.
An increase in the transverse dimension of the airway was observed from the subglottic region to the cricoid ring.
An increase of QT dispersion is associated with higher cardiovascular mortality.
An increase of search for meaning ( interpretation , life story integration ) was confirmed only up to middle adulthood.
An increase of the GS was associated with a decrease of the AAO.
An increasing amount of evidence suggests that individuals with AMD are also at risk of systemic diseases such as stroke.
An increasing concern affecting a growing aging population is working memory ( WM ) decline.
An increasing evidence base suggests that low bone mineral density ( BMD ) and fractures are associated with cardiovascular disease ( CVD ) .
An increasing incidence of glioblastoma has been observed over the last @number@ years.
An increasing inhibitory competence resulting in the ability of movement lateralization is thought to be the underlying mechanism.
An increasing number of Australia's ageing population are aging with long-term physical impairments.
An increasing number of comorbidities was associated with poor SRH at baseline.
An increasing number of longitudinal cohort studies have identified a risk increase for dementia by the chronic use of drugs with anticholinergic properties.
An increasing number of older people receive organ transplants for various end-stage conditions.
An increasing number of patients seek minimal invasive procedures.
An increasing number of randomized controlled trials show that purpose in life can be raised.
An increasing number of studies focus on discourse production in patients with neurodegenerative diseases and underline its clinical usefulness.
An increasing number of the elderly results not only in aging society , but in increasing morbidity as well.
An increasing sIgE level was correlated with higher SPT grades in both Der p and Der f.
An incremental cost-effectiveness ratio ( ICER ) was calculated for a 10-year horizon and tested with one-way and probabilistic sensitivity analyses.
An independent assumption-free voxel-wise analysis identified strategic voxels in these same tracts.
An independent cohort of @number@ Italian cases and @number@ Italian control individuals were used for replication.
An independent component analysis was applied to the RS-fMRI , followed by template matching to identify neuronal components ( NC ) .
An independent expert observer evaluated frontal images with digital laterality randomization to identify the side with more wrinkles and more ptosis.
An independent observer confirmed all algorithm outputs.
An independent samples t test compared eHealth literacy among users and non-users of Web @number@ for health information.
An in-depth analysis was undertaken using @number@ semi-structured interviews conducted with workers aged @number@ to @number@
An in-depth discussion of administration of tumescent local anesthesia and proper liposuction technique is also included.
An index of global cognitive function scores was derived by averaging z-scores of all tests.
An index of global cognitive function scores was derived by averaging z-scores of all tests.
An index of the ratio of ECW and ICW was calculated using MFBIA.
An Index Risk of Vitamin D Insufficiency ( IRVDI ) was designed and subsequently validated.
An indirect link between bereavement and mortality was found showing for each year since loss the mortality risk decreased by about @percent@.
An individual approach to weight management that includes the participation of the patient , co-morbidity , functional status , and social support should be aspired.
An individual differences analysis in older adults found false recollection rates predicted activity in several regions. including bilateral middle / superior temporal gyrus.
An individual difftemp of @number@.0-1.5°C along with malaise might indicate fever.
An individual's age and hazard of dying from each complication were then used to calculate years of life lost to each complication.
An individual's death triggered a reproductive event by one immediate neighbour.
An individual's fat mass increases and muscle mass decreases with aging.
An induced exposure analysis was conducted to calculate crash involvement ratios ( CIRs ) for all two-vehicle fatal intersection crashes.
An inductive content analysis approach was adopted.
An inductive content analysis of responses revealed a range of encounters with ethical review panels spanning positive , negative , and neutral experiences.
A nine-camera motion capture system was used to collect the trajectories of @number@ reflective markers placed on bony landmarks of participants.
An infection control team ( ICT ) is responsible for management of health care-associated infections at our institution.
An infectious underlying disease was found in @number@ patients.
An inflammatory process with activated monocytes / macrophages may play a role in the increased permeability of the blood brain barrier in patients with CSVD.
An inflammatory response ensued as indicated by increases in cytokines interleukin @number@ beta ( IL-1β ) and IL-8 as well as a substantial neutrophil infiltrate.
An informant completed a baseline questionnaire that included @number@ memory and @number@ nonmemory SCC questions relating to the participant.
An informed consent is mandatory to protect the rights of the patient as well as the practitioner.
An infrequently studied question is how diverse combinations of built environment ( BE ) features relate to physical activity ( PA ) for older adults.
An inhibition ELISA of anti-CarP antibodies by CarALB and citrullinated albumin ( citALB ) was performed using eight RA patients ' sera.
An inhibition mechanism is thought to suppress overt movement during motor imagery , but it does not effectively suppress autonomic or postural adjustments.
An in-home face-to-face interview was administered.
An in-house RNase-L immunoassay was developed.
An initial assessment was performed to document the presence of MBs and silent ischemic brain lesions and to map the location of the MBs.
An initial association with cognitive flexibility remained inconclusive.
An initial quantitative survey placed students in three embedded units of analysis : neutral , pro-aged , and anti-aged bias toward older adults.
An initial screen by abstracts and titles was performed , and relevant full articles were then reviewed and assessed for their methodologic quality.
An initial screening study of sixteen compositions was used to identify regions of glass formation and cement compositions with promising rheological properties.
An initial study ( @date@ to @date@ ) had found intervention effects on health-related quality of life.
An initial study in mice revealed a narrow therapeutic range for this tetrabasic compound , while significantly reduced toxicity was observed for some tribasic analogues.
An innovative clinical model , the dedicated education unit ( DEU ) , has been used globally with positive results.
An innovative integrated health system built around medical systems and strategic partnerships is proposed to combat NCDs.
An innovative statistical methodology for these types of data is described.
An inordinately high amount of time and money is thus spent on research that does not always have the required human impact.
An in silico pathway analysis was performed on target genes of microRNAs associated with the pollutants.
An instrumental variable approach is used.
An instrumental-variables regression model was used to minimize estimation bias resulting from unmeasured confounding between lapses and service use.
An instrumented car was used to measure the emergency braking times during braking tests with and without a distractor.
An integrated model revealed dominant effects of late MT stage and early postmenopause , with anxiety contributing to hot flush severity.
An integrated multidisciplinary pediatric-adult service can improve the transition process and preparation of the teenager for adult health care.
An integrated person-centred model of care may provide a contextually appropriate approach for practice.
An integrated review of literature was undertaken , searching CINAHL , PubMed , Academic Search Premier , Medline , and PsychInfo.
An integrated statistical method with generalized estimating equations was applied to study trajectory stability.
An integrative model of these tensions between positive and negative experiences is presented and discussed.
An integrative review methodology was applied to analyze and synthesize primary research reports.
An intense search is going on for biomarkers of the disease process.
An interaction between age and sex accounted for statistically significant differences in the values for weight , BMI , and lymphocyte and eosinophil counts.
An interaction between FTO and APOE was found , with increased risk for dementia for those carrying both FTO AA and APOE ϵ4.
An interaction between pain and sex explained this effect.
An interaction effect between age and gender was significant in the symmetry index of anteroposterior acceleration.
An interaction effect between any-type shift work and education on cognitive performance at retirement was noted.
An interaction term was used to determine whether age modified the effect of glucose status on AD.
An interaction was detected , whereby smoking was associated with shorter LTL in HIV-uninfected subjects only.
An interaction was found between age group and NOF on word latencies.
An interaction was found between bio-T and age ( P < .0001 ) , and bio-T and education ( P = .044 ) .
An intercoder reliability study was undertaken.
An interdisciplinary healthcare team can help in these areas.
An interesting exception is the xanthine oxido-reductase produced ROS and their role in cardiovascular disease.
An intergroup comparison did not show any statistically significant differences between the groups in any of the parameters analyzed.
An international expert panel was convened to deliberate the management of azole-resistant aspergillosis.
An internationally accepted sensory analysis method specifically designed for sparkling wine is required.
An international workshop was convened to identify KT priorities for acute and rehabilitation care of TBI and develop KT projects addressing these priorities.
An interplay effect between mid-life SES and place of residence on cognition was only found for Baby Boomers.
An interrelation was observed between tau protein deposition in the brain and that in the posterior pituitary.
An interruption in homeostasis induces a cascade of conserved adaptive responses in glia.
An interventional study with the focus of urinary incontinence could improve the effectiveness of fall prevention among these patients.
An intervention study combining these features should be carried out to promote better cognitive health in communities.
An intervention study showed that only non-carriers had increased concentrations of long-chain n-3 PUFA in response to supplementation.
An interview and functional assessment using a questionnaire and Pune-FAAT tool was carried out in 2013-14.
An interview was done with caregivers and the collected verbal material was analyzed through the Collective Subject Discursive Technique.
An interview with a woman with strong convictions.
An intriguing observation was the significant overlap between gene expression changes induced by Aβ and those induced by Cry5B , a bacterial pore-forming toxin.
An intriguing type of protective variant is buffering variants that protect against variants that have deleterious effects.
An intuitively straightforward genesis ; @number@
An inverse correlation was found between alpha asymmetry and STAI ( rs = @number@ P = @number@ ) in the young group.
An inverse coupling of glutamate concentrations in the ACC and activation of the ventral striatum was observed in adolescents.
An inverse probability weighting approach was used to convert our observed frequencies to population prevalence of SS.
An inverse relationship between educational level and dementia has been reported in several studies.
An inverse relationship between the incidence of the ACCORD primary outcome and baseline cognitive score was demonstrated.
An inverse relationship was found between the perceived level of threat posed by a flu pandemic and nurses ' willingness to work.
An inverse relationship was observed where those with more CVD risk factors had a lower ( worse ) cognitive function score.
An inverted-U profile was only observed for the time-scale relevant to the sensorimotor control process.
An investigation of mechanisms accounting for alcohol's effects on driving in older and younger adults is required.
An investment in initiatives to both identify and support people with hearing loss in the Pacific is necessary.
An in vivo clinical method to characterise arterial stiffness of the central microcirculation was developed.
An IQR increase in SO₄ over a 90-day period was associated with a decrease of @percent@ 5mC ( @number@ @date@ % ) in LINE-1.
An irregular sac shape was demonstrated for @number@ aneurysms on CE-MRA but only 13 / 21 aneurysms on 3D TOF-MRA.
An isocaloric high-fat diet does not cause insulin resistance.
An isoluminant red-green stimulus composed of horizontal gratings was presented in an onset-offset manner.
Anisometropia defined as greater than or equal to @number@ D was calculated for all refractive components.
An iterative process was used to develop modules , and user feedback was collated.
An IκBα super-repressor blocks oxidative stress-induced activation of NF-κB and IGF2 imprinting is maintained.
Ankle-brachial index ≤0.90 defined peripheral artery disease.
Ankle co-activation was twofold elevated in seniors compared to young adults during SLEO ( p < @number@ ) .
Ankle fractures represent an exceptionally common injury within the elderly population.
Ankle joint stiffness was lower in elderly subjects only in high hopping intensities ( @percent@ and Max ) .
Ankle range of motion for C was significantly less during ankle swing compared to PD ( p = 0.04 ) for the Kinect.
Ankle range of motion for symptomatic knee-OA was greater compared to asymptomatic knee-OA for all walking tasks ( p < 0.050 ) .
An mFI score of @number@ or higher was defined as a high mFI.
An MMSE < 24 ( out of @number@ ) was found in @percent@ of individuals.
An MR imaging based grading system for ISLD was developed and ranged from Grade A ( mild ) to Grade D ( severe ) .
An MTH ratio located in the anterior and posterior aspects of the upper arm , upper leg , lower leg , and trunk was calculated.
ANM was related to five commonly reported occupational exposures using bivariate and multivariate Cox proportional hazards regressions.
Annealed HXLPE showed higher oxidation ( oxidation index > @number@ ) than remelted HXLPE and delamination wear.
Annealing by XPG is cooperative , rather than additive , with WRN annealing.
Ann Neurol @number@ ; 81 : 171-180.
Ann Neurol @number@ ; 81 : 383-394.
Ann Neurol @number@ ; 81 : 430-443.
Ann Neurol @number@ ; 81 : 583-596.
Ann Neurol @number@ ; 81 : 871-882.
Ann Neurol @number@ ; 82 : 208-222.
Ann Neurol @number@ ; 82 : 311-314.
Ann Neurol @number@ ; 82 : 371-384.
Ann Neurol @number@ ; 82 : 562-577.
Ann Neurol @number@ ; 82 : 706-718.
Annual attack rates in the USA range from @number@ to @percent@ in community-dwelling older adults and 5-10% in older adults living in congregate settings.
Annual change increased with age , particularly within superior regions , with age-related decline estimated to begin in the fifth decade.
Annual changes in hormone levels and urologic outcomes were calculated using mixed-effects regression models.
Annual changes in low frequencies ( @number@.5-2 kHz ) and high frequencies ( 3-6 kHz ) were calculated.
Annual composite scores of EXEC and MEM functions were derived from item response theory.
Annual conversion rates to dementia were compared between the patients who fulfilled the criterion on functional activity and those who did not.
Annual costs are enormous for musculoskeletal diseases such as osteoporosis and sarcopenia and for bone and muscle injuries , costing billions annually in health care.
Annual detailed assessment of @number@ measures of muscle strength and @number@ motor performances were summarized in a composite measure of global motor function.
Annual incidence rates for Alzheimer's were @percent@ to @percent@ whereas that for vascular dementia was found to be as low as @percent@.
Annual incidences of hip fractures were calculated and tested for trends.
Annually , fibrosis represents a huge financial burden for the USA and the world.
Annually , many vulnerable older adults suffer various forms of abuse threatening their overall health , quality of life , and survival.
Annually , @percent@ of the sample filled prescriptions for COPD maintenance medications.
Annually reported hysterectomy at visits @number@ to @number@ was verified with medical records when available ( @percent@ ) .
Annually thereafter , they completed a battery of @number@ cognitive tests.
Annual mortality was @number@ % and was higher if AF occurred ( @number@ % ) .
Annual per-patient costs of healthcare utilization were €579.
Annual PV change rate was @number@ mL / year ( @percent@ CI , @number@.47-0.55 ) .
Annual questionnaire assessed mood , function and health status.
Annual sex-specific age-standardized mortality rates ( ASMR ) were calculated by means of direct standardization using the WHO world standard population.
Annual suicide rates were calculated by gender and age group , and odds ratios with @percent@ confidence intervals were examined.
Annular and leaflet metrics were quantified and regression equations were prepared.
An obvious sign of ageing is hair greying , or the loss of pigment production and deposition within the hair shafts.
An OCT attenuation coefficient parameter ( μ t ) was derived based on the Beer-Lambert law as a function of backscatter signal slope.
Anodal transcranial direct current stimulation ( anodal-tDCS ) , with its potential to enhance neuroplasticity , may allow improving cognition in MCI.
An often overlooked , yet increasingly common , behavior in older individuals is alcohol consumption.
An older adult may have more difficulty recovering from an abuse incident.
An old-new paradigm was used to assess children's recognition ability of own- and other-race faces.
An oligonucleotide probe encompassing an LXR-RXR / RAR motif bound to adrenocortical and epidermal keratinocyte nuclear proteins in EMSAs.
Anomalies in dismantling the machinery of DNA replication can compromise genome integrity and contribute to tumorigenesis and aging.
Anomalous posterior vitreous detachment may be a key event initiating the formation of iERM.
A nomogram was used to represent results of the metaregression model.
A noncytotoxic C-terminal fragment of Clostridium perfringens enterotoxin ( cCPE ) is a natural ligand for claudin-4.
A non-enzymatic reaction between reducing sugars and amino groups of proteins , lipids and nucleic acids contributes to the aging of macromolecules.
A nonexercise group ( normal healthy control ) consisting of @number@ subjects were also recruited by random selection and through contacting local elderly centers.
A non-fasting venous blood sample was obtained from all study participants.
An ongoing concern in long-term care ( LTC ) is that pain problems are often not identified correctly.
An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit.
A noninvasive option to volumize target wrinkle areas could also extend benefits of commonly used cosmetic anti-aging products.
A non-IV bisphosphonate comparison group included patients prescribed an oral bisphosphonate for @number@ days or less.
A non-linear behavior in the apical uptake dynamics was observed , which does not follow the classic saturation dynamics of traditional biochemical models.
An online learning management system housed the resources to support therapist training.
An online questionnaire consisting of @number@ juvenile face images was created using SurveyMonkey®.
An online survey explored the relations between negative health perceptions by long-distance caregivers and conflict frequency and conflict strategy usage.
An online survey was sent to all enrolled students.
An online tool kit containing all workshop materials is available.
A non-painful fast local heating protocol was applied to the sacral skin in @number@ older subjects with various vasodilatory functions.
A non-parametric equation derived from a probabilistic Bayesian network ( BN ) was established by including sex , age , body weight and height.
A non-parametric technique was applied to fit the resulting age-volume data.
A nonsignificant negative association was estimated for PMcoarse ( adjusted OR = @number@ @percent@ CI : @number@ @number@ per @number@ μg / m3 ) .
A nonsignificant trend for improvement in sleep efficiency was observed.
Anonymized clinical data were rated against the NIA-AA criteria by raters who were blinded to clinical and pathologic diagnosis.
Anonymized data was taken from the methadone register of Basel-City.
Anonymized data were coded and analyzed by using SPSS and compared with the population statistics of Berlin.
Anonymous online media comments often contain extreme viewpoints and may therefore help in understanding challenges of firearm safety counseling.
An open-coding scheme using conventional content analysis was employed.
An open-ended question about experiences of the intervention was included in the last questionnaire.
An open-label study was conducted to investigate the effects of this nutritional supplement on skin properties.
An open question concerns how these processes support cognitive flexibility in rule-switching tasks.
An open subcostal mini-incision ( MINI ) has been utilized in @number@ living donors since @number@
An open trial was conducted using fullerene nanoemulsion on skin twice a day for @number@ days.
An operative definition of frailty , useful for the classification of the individual quality of aging , is needed.
An ophthalmological examination including slit-lamp examination was conducted.
An opportunity for those who experience prison on a daily basis to express their views.
An optimal approach would be to initially filter according to color and then process letter forms in the attend color to identify targets.
An optimal BMI may be based on the individual , who exhibits pre-existing diseases or not.
An optimal combination and timing of tests , as extractable from this study , will aid in controlling their impact.
An optimal therapeutic approach to treat should involve medical treatment with drug and behavioral therapy in addition to lifestyle advice.
An optional treatment was offered at the end of the study , with participants allowed to choose one of the products.
An oral cobalamin regimen is proposed for elderly patients with cobalamin deficiency but with no severe neurological signs.
An orbicularis muscle lift is performed for support and a lateral retinacular suspension is performed if necessary.
An ordinal logistic regression was used as a measure of association.
An ordinal regression assessed specific neuropsychological influences on CDT performance.
An ordinal scoring method was developed for each of the three traits.
Anorexia nervosa ( AN ) is a complex and heritable eating disorder characterized by dangerously low body weight.
Anorexia recognizes a multifactorial origin characterized by various combinations of medical , environmental and social factors.
An organismal perspective is then used to examine the relationships between reproduction , lifespan regulation and senescence.
An organism's pro-inflammatory status may underlie the aging process and age-related diseases.
An organism's well-being is facilitated by numerous molecular and biochemical pathways that ensure homeostasis within cells and tissues.
An organized program of music therapy , orientation training , art-cognitive activities and physical activities was carried out for the intervention group.
A normal circadian rhythmicity was recognizable for TRH and TSH in young , middle-aged subjects and for TSH in elderly subjects.
A normal level of vitamin D is defined as a 25OHD concentration ≥30 ng / mL.
A normal ratio was observed in @percent@ of patients.
A normal signature comprising @number@ CpG loci was highly enriched on the X chromosome.
Anosmia or hyposmia had no statistical relationship with the amount of NRC in PD.
A nosocomial infection was diagnosed for @percent@ of the patients.
A notable exception was physician respondents from Italy , where most generalists and specialists actually favoured screening.
A notable finding from this study was the lack of consistent relationships between medication use and neuropsychiatric symptoms across the @number@ illnesses.
A notable reduced perfusion as a whole was observed in osteoporotic subjects.
A notable variety of methods for prevention and therapy of iron toxicity are now becoming available.
Another age predictor model was also developed using a 40-blood sample training set that accounted for @percent@ of the age variance.
Another aim is to understand how a high pathogen burden influences health and well-being during development and adulthood.
Another alternative approach under development is neuroprotective agents such as antioxidants , anti-inflammatory drugs , compounds acting against glutamate mediated neurotoxicity.
Another analyzed relationship was the SOC level against the background of socio-demographic factors.
Another approach is to enhance physical function despite the occurrence of comorbid conditions through enhancement of the neuromuscular system.
Another aspect is the accompanying geriatric treatment which is associated with a significant reduction of perioperative and postoperative complications.
Another automatic segmentation method using a trimmed likelihood estimator ( TLE ) was implemented for comparison with our proposed segmentation framework.
Another challenge is the population composition , i.e. , aging in developed countries which call for new solutions and procedures , particularly from cost wise.
Another clinical application of the neuropsychological assessment of declarative memory is the longitudinal evaluation of an individual's performance change.
Another common characteristic of these agents is their capacity to reduce aging-associated diseases and to confer protective responses against ischemia-induced organ damage.
Another composite criteria-based vascular condition named chronic cerebrospinal venous insufficiency ( CCSVI ) was recently introduced.
Another definition marks success as outcome oriented.
Another ' de novo ' meta-analysis of two long-term RCTs showed a @percent@ increased probability of remission from the metabolic syndrome.
Another example in which high levels of support may not necessarily translate into priority implementation of promising interventions is the realm of patient-centred care.
Another exciting discovery is that the regulation of heat stress cognate @number@ plays important roles in the aging process and aging-related diseases.
Another exciting discovery is the regulation of GRP78 by insulin / IGF-1 signaling pathways impacting cell proliferation and survival.
Another , experiencing cardiogenic shock at baseline , died of intractable heart failure after @number@ weeks.
Another explanation might be that older participants use compensatory strategies , often considering happy faces as previously seen.
Another factor to consider is the changing age structure of the population.
Another feature is pronounced cell loss in the brain leading to an enlargement of the ventricular area and a decrease in brain weight and volume.
Another finding from the microarray study is a negative relationship between GAD67 mRNA expression and age at death.
Another fraction of the identified compounds belongs to the group of trialkyl phosphates.
Another important consequence is reduced mobility , which leads to loss of independence.
Another important factor was a high level of predictability , which tended to decrease role strain.
Another important indicator is the disease specific survival ( DSS ) .
Another important mechanism that controls p53 function is its conformational stability since p53 is an intrinsically unstable protein.
Another important recent development is the discovery of long-term ' memory ' for early-life experiences in longevity determination.
Another important source is the exposure to environmental factors , which further induces oxidative stress in the cells.
Another issue to be considered is the optimal data recording , storing and processing.
Another major age-related eye disease of the cornea that leads to vision impairment and potentially blindness if left untreated is Fuchs ' endothelial corneal dystrophy.
Another major force appears to be evolutionary pressure ; individuals that best fit the environment out-reproduce those that fit less well.
Another mechanism involves a decrease in the preference for sweet foods during the follicular phase.
Another mutation was also found in a case with a repeat expansion mutation in C9orf72 confirmed by Southern blot.
Another neuropathy caused by a PMP22 duplication is Charcot-Marie-Tooth disease type 1A ( CMT1A ) .
Another nexus exists between cellular oscillators and metabolic sensing , in particular to the aging-suppressor SIRT1 , which acts as an accessory clock protein.
Another nontraditional training approach combines cognitively with physically challenging tasks to induce multimechanistic effects , which might even interact positively.
Another @number@ elderly having regular exercise habits were recruited from community centers for inclusion in the exercise group.
Another @number@ healthy age-matched adults ( group @number@ ) were also included to serve as the control group.
Another @number@ men and women participated in an 8-day test-retest analysis.
Another @number@ people over the age of @number@ had never fallen at the same time were selected as controls.
Another @number@ residents aged from @number@ to @number@ years old in Chengdu were surveyed.
Another observation was weak correlation between the sense of coherence and the individuals ' level of education.
Another option was full-contour zirconia FDPs using high translucent zirconia.
Another pathway that was found bypassed 1-C metabolites ( Hps → Iron st → Antiox ) .
Another patient had a biochemical recurrence at @number@ months and underwent salvage radiotherapy.
Another problem that we mostly focus on the results exceeding the normal values , and do not pay enough attention to the low values.
Another protein indirectly affecting NRG1-ERBB4 signaling is β-secretase , which is encoded by the BACE1 gene , and activates NRG1 by proteolytic cleavage.
Another purpose was to evaluate the effects of site of measurement , age , gender and body mass index on liver stiffness values.
Another secreted factor , the hyposialylated form of angiopoietin-like-protein @number@ ( ANGPTL4 ) was found to favor albuminuria in rats and in minimal change disease.
Another strategy may involve activation of PMRS.
Another type ( Type-2 ) of genes , including RUNX1 and GATA2 , are related to progression from low-risk to high-risk MDS.
Another very important factor in elderly cancer patients is the geriatric assessment including not only age but also functional , social and mental status.
Another view has been relatively overlooked - namely that some of these changes arise in adaptive response to protect network function in aged animals.
A noticeable clinical and histological improvement was observed after Nd : YAG 1320-nm treatment.
An outbreak of measles in another region of New Zealand prompted our organization to review the measles immunity of healthcare workers.
An outstanding question remains if tau pathology can also be seen in patients with Huntington's and Parkinson's disease who had received foetal neural allografts.
ANOVA analyses were performed to determine differences these parameters among all groups.
ANOVA analysis demonstrated that for overall adjustment , and all subscale scores , the Italians were more distressed about their appearance than UK comparators.
ANOVA and random forest were used for testing between-cohort differences in demographic-clinical variables.
ANOVA , correlation analyses and Bland-Altman plots were computed to determine validity of accelerometers using GRF.
ANOVA models were estimated to examine associations between F ( @number@ ) -IP tertiles and baseline adiposity and changes in body composition.
ANOVA model tested whether the PHQ-9 and R-MBPC subscales differed by stressor.
ANOVA or Kruskal-Wallis tests ( data not normally distributed ) were conducted , with Bonferroni correction , to compare anatomical measurements between groups.
ANOVA revealed differences in mean ADC among age groups ( F = @number@ P < @number@ ) .
ANOVA showed no significant differences between group means ( P always > .05 ) .
ANOVA test was used to analyze the differences.
ANOVA was used to compare efficacy outcome differences ( DSG vs vehicle ) by age ( 25-64 or ≥65 years ) .
A novel APP / PS1 mouse model in the senescence accelerated mouse prone @number@ ( SAMP8 ) background SAMP8 APP / PS1 was generated.
A novel approach for biomarker identification and validation , based on multivariate methodologies , is also discussed.
A novel blood-pressure independent arterial stiffness parameter , the cardio-ankle vascular index ( CAVI ) , has been developed and is used worldwide.
A novel computational model of personalized metabolic changes in cancer was outlined with applications in patients with breast cancer.
A novel cyclic prodrug of S-allyl-glutathione ( CP11 ) , obtained by using an acyloxy-alkoxy linker , was estimated for its pharmacokinetic and biological properties.
A novel finding was that some individuals reported phantom smells with an autobiographical connotation.
A novel GM / WM-based approach with a compact whole brain representation is introduced and applied to study the brain and perform neuroimage processing.
A novel grading system for submandibular gland ptosis has been proposed.
A novel grading system is proposed to quantify the degree of descent of the submandibular gland in relation to the inferior border of the mandible.
A novel likely pathogenic homozygous variant in ALS2 was identified in @number@ patient.
A novel method for the fabrication of condensation-like engineered microtissues ( EMTs ) that utilizes hydrophilic polysaccharides to induce cell aggregation is reported here.
A novel model based on NT-proBNP could offer help for risk stratification.
A novel nor-betaenone compound , 11-norbetaenone ( @number@ ) , was isolated from the culture broth of an entomopathogenic fungus Lecanicillium antillanum.
A novel @number@ , ( FapyA ) specific incision activity of NEIL2 was also stimulated by CSB.
A novel peptide-mediated siRNA transfection approach was used to inhibit Nox4 expression with minimal cellular toxicity.
A novel rare variant -573A / G was found and was found in heterozygote state only in five persons in the Longevity group.
A novel role of epithelial marker E-cadherin , as a sensitizer for chemoresistant prostate cancer cells by inhibiting Notch signaling , has been found.
A novel selective estrogen receptor modulator , bazedoxifene ( BZA ) , was recently approved for the treatment of postmenopausal osteoporosis in Japan.
A novel , simple method , referred to as the TSP , was used in this study.
A novel splice-site mutation resulting in skipping and missense mutations ( p.R538C ) in exon @number@ was identified in the patient.
A novel technology based on fractional Hybrid Energy™ ( HE ) , combines RF and an additional electrical energy for enhancing the thermal effect.
A novel therapeutic approach ( 11β-HSD1 inhibition ) is promising in treating the HPA axis hyperactivity in chronic diseases with MetS.
A novel weighted square-root LASSO procedure is proposed to estimate the regression coefficient matrix.
A novel WRN frameshift mutation ( p.N1370Tfs 23 ) was identified in the three cancer patients and in the youngest unaffected daughter.
An overall decrease is observed in BDNF expression in schizophrenia compared to healthy controls and in older individuals compared to a younger cohort.
An overall delay in performing the task was observed for patients with insomnia disorder.
An overall score of care , defined as the sum of achieved indicators , was calculated.
An overall significant time-of-day effect was observed for all selected COP variables.
An overlap has been observed between chronic inflammation , age-related comorbidities , lifestyle , and the long-term toxicity of ART.
An oversupinated foot was inversely associated with hallux valgus ( aOR @number@ @percent@ CI @number@.74-0.97 ) .
An overview and evaluation of the research of combination therapy in skin of color is presented.
An overview is given on caffeine content in different tea leaves beverage.
An overview of existing challenges and future directions will also be discussed.
An overview of posterior cardiac restoration , structure , and torsion are presented.
An overview of the basics of ROS / RNS and antioxidant chemistry and biology occurring in skeletal muscle is first provided.
An overview of the epidemiology of malignant tumors in the Czech population is available online at www.svod.cz.
An overview of the model is presented followed by a discussion of usual stressors encountered as people age and their common responses to these stressors.
An overview of the most reported work outcomes is outlined.
An overview on the vascular biology of ageing and hypertension is presented and novel molecular mechanisms contributing to these processes are discussed.
ANP level was higher in women than that in men in all age groups.
An RD must assess each older adult's risks vs benefits for therapeutic diets.
ANRIL identification emphasizes the underestimated role of long noncoding RNAs.
An R-implementation of the algorithm is provided.
An ROC analysis was also performed to assess the ability of each metric to classify older and younger participants.
An S3 after the age of @number@ is a relatively uncommon finding and therefore should be a specific sign of cardiac disease.
An SES composite was derived from education and poverty status.
An SF-12 was administered.
ANS highlights the sensitivity of specific cellular targets , including the nucleus and particularly the nucleolus , to thermal stress and proteasome inhibition.
ANS imaging also highlights non-amyloid deposits of glial fibrillary acidic protein in brain tumors.
ANS is relatively nontoxic and enters live cells and cells or tissues fixed in formalin.
AN subtype analyses ( @number@ AN restricting ; @number@ AN binge-purge ) were performed.
ANSWER : Botulinum toxin is not expected to be present in systemic circulation following proper intramuscular or intradermal injection.
Answering these questions will facilitate the integration of geriatric issues into future mechanistic and clinical studies that affect management and care of acute kidney injury.
Answers to these questions may be sought by reference to the mechanisms by which human aging might have evolved.
Antagonist coactivation may play a protective role in stabilizing the knee joint and maintaining constant motor output.
Antagonist coactivation was minimal and did not show age- or intensity-specificity.
Antecedents to resilient ageing were found to be adversity and protective factors , while the core attributes include coping , hardiness and self-concept.
Antenatal adverse events can operate by causing structural changes in the developing lung , causing low birth weight and prematurity and altered immunological responses.
Anterior and posterior thigh MTH as well as A50 : P50 MTH ratio was higher in men than in women.
Anterior and posterior thigh MTH was positively ( p < @number@ ) correlated to aLM and aLM index in men and women.
Anterior and posterior tongue elevation strength measures were obtained using a standard method.
Anterior approaches may provide another avenue of treatment , but only a few studies have been conducted on these implants in patients with osteoporosis.
Anterior capsule specimens were obtained by performing a @number@ mm continuous curvilinear capsulorhexis and collecting the resulting disk of capsular tissue.
Anterior Commissure ( AC ) and TNM classifications was used to determine the location and tumor stage.
Anterior lens capsule material was collected during surgery.
Anterior lens surface shape could not be determined due to the overlapping region with the iris.
Anterior-posterior ( AP ) and medio-lateral ( ML ) sway speed , magnitude , and complexity ( quantified by multiscale entropy ) were calculated.
Anterograde transport supplies distal axons with newly synthesized proteins and lipids , including synaptic components required to maintain presynaptic activity.
Anteroposterior ( AP ) instability was assessed with use of a KT-2000 arthrometer ( MEDmetric , San Diego , CA ) .
Anteroposterior intersegmental angular sway was not age dependent.
Antero-posterior knee radiographs were obtained in standing position and they were evaluated according to Kelgren-Lawrence ( K-L ) grading scale.
Anteroposterior tortuosity of the retinal vein at the AV crossing is increased with age.
Anthocyanins represent water-soluble flavonoid species , commonly found in higher plants , the richest plant source representing berries.
Anthropometrical data , information about lifestyle habits and co-morbidities were obtained.
Anthropometric analyses of standardized frontal view and profile photographs could help to investigate such changes.
Anthropometric and biochemical data were collected from the hard copy archive.
Anthropometric and biochemical examination of parameters such as estrogen and serum lipids was also performed for these individuals.
Anthropometric and blood analysis data were also recorded.
Anthropometric and blood parameters were assessed before and at the end of the intervention period.
Anthropometric and carbohydrate and lipid metabolic parameters and the levels of sex hormones , anti-Müllerian hormone , resistin , and adiponectin were investigated.
Anthropometric and demographic data were collected , and lung function and quadriceps maximal voluntary contraction were measured.
Anthropometric and demographic data were collected during routine medical exams.
Anthropometric and functional measurements were also conducted among elderly subjects.
Anthropometric , balance , strength , and gait tests were conducted.
Anthropometric , biochemical , dietary , and genotype analyses were performed.
Anthropometric , biochemical , thyroid ultrasonographic , and other metabolic parameters were all measured.
Anthropometric , body-composition , and flexibility measurements were made at baseline and post-study.
Anthropometric characteristics , plasma Q10 and lipid peroxidation ( MDA ) levels were determined.
Anthropometric , clinical , biochemical , lifestyle and dietary variables were determined.
Anthropometric data , lifestyle and parental factors , blood pressure , lung function , X-ray of heart and lungs and maximum work performance were recorded.
Anthropometric data were measured , and lifestyle , dietary , and sociodemographic factors were obtained through self-administered questionnaires.
Anthropometric evaluation and biochemical tests were performed.
Anthropometric evaluations and biochemical tests were performed.
Anthropometric measurements concerned WC and blood pressure.
Anthropometric measurements were also assessed.
Anthropometric measurements were also made throughout the study period.
Anthropometric measurements were obtained using standardized techniques.
Anthropometric measurements were obtained using standardized techniques and equipment.
Anthropometric measurements were taken at birth and at @number@ subsequent in-person assessments.
Anthropometric measurements will be collected.
Anthropometric measures and the Toronto Clinical Neuropathy Score were registered.
Anthropometric measures , blood pressure , metabolic profiles and intake of dietary fatty acids were obtained from participants using standard guidelines.
Anthropometric measures of growth and body composition were obtained at enrollment from mothers and monthly through @number@ year of age from infants.
Anthropometric parameters and physical fitness , i.e. , muscle strength and flexibility , were measured.
Anthropometric parameters ( arm circumference , waist circumference and triceps skinfold thickness ) were measured , and information was gathered on nutritional habits.
Anthropometric parameters ( BSA , LBM ) and demographic parameters ( female gender ) show strong influence on TSH concentrations.
Anthropometrics , anamnesis , and biochemical data were collected.
Anthropometrics and hemoglobin were measured in the field , and anemia prevalence was evaluated.
Anthropometric , socioeconomic , and clinical characteristics were assessed at baseline in a personal interview and clinical examination using validated scales and medical history.
Anthropometric technique was adopted to estimate the cranial volume using maximum length , width and auricular height of head.
Anthropometry , bioelectric impedance analysis and indirect respiratory calorimetry were performed ; lipid and carbohydrate parameters were measured.
Anthropometry , blood pressure ( BP ) measurement and fasting blood-tests ( glucose , lipids ) were performed according to standard protocols.
Anthropometry , including BMI and blood pressure were also measured.
Anthropometry , including body weight , stature , and six circumferences from the body trunk and extremities were taken from each participant.
Anthropomorphic measures were similar in both groups ( P > @number@ ) .
Anti-acetylcholine receptor antibodies were positive in only @percent@ of infantile-onset , but nearly @percent@ of elderly-onset patients.
Anti-ageing products are of a great importance in cosmetic fields.
Anti-aging Chinese medicines have been used in traditional beverages to promote health and prevent diseases.
Antiaging medicine is nowadays an equivocal topic frequently used in geriatric medicine.
Anti-aging molecule evaluations were performed with a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7.
Anti-aging properties have been attributed especially to antioxidant phenolic plant metabolites that represent food additives in our diet.
Antiangiogenic tumor therapy has failed in the adjuvant setting.
Anti-apoptotic BCL-2 proteins are considered promising targets for drug discovery and exciting clinical progress has stimulated intense investigations in the broader family.
Anti-apoptotic protein Bcl-2 was up-regulated and apoptosis-promoting protein Bax was down-regulated in Gnaq-SY5Y cells after treatment with H2O2.
Anti-apoptotic strategies cover a broad range of approaches.
Antiarrhythmic drug discovery was mainly hindered by the limited knowledge of the molecular underpinnings of cardiac electrophysiology in health and disease.
Antibacterial activity was tested after aging for @number@ days using the direct contact test ( DCT ) .
Antibacterial experiment results showed that QCZ NPs acted against E. coli and B. subtilis by disrupting the bacterial cell wall and membrane.
Antibacterial susceptibility patterns among the bacterial pathogens are evolving , and knowledge of local susceptibility patterns is useful in antibacterial selection.
Anti-biofilm activity was assessed using a human dental plaque microcosm biofilm model.
Antibiotic resistance was determined both phenotypically and genotypically , and clonality was assessed by PFGE.
Antibiotic susceptibilities and multilocus sequence typing of MSSA isolates were also determined.
Antibodies against T. gondii were examined by enzyme-linked immunosorbent assay ( ELISA ) .
Antibodies are encoded by the immunoglobulin genes and AID acts as a transcription-dependent DNA mutator on these genes to improve antibody affinity and effector functions.
Antibodies are thought to play an essential role in naturally acquired immunity to malaria.
Antibodies were determined with reported techniques.
Antibodies were measured using an enzyme-linked immunosorbent assay ( ELISA ) .
Antibody blocking revealed that PATE1 was involved in sperm-egg penetration and sperm motility.
Antibody levels against EBA140 , EBA175 , EBA181 , PfRh2 , PfRh4 , and MSP2 , were measured by ELISA.
Antibody-mediated neutralization of NOX5-L attenuated tumor progression in a mouse xenograft model.
Antibody @number@ was compared in one-site and competitive ELISAs for oligomer binding specificity.
Antibody responses to RSV were in the inverse direction.
Antibody responses to SGG are associated with CRC and its precursors.
Antibody responses to the vaccine strains were lower in the aged.
Antibody seroprevalence and mean serum antibody levels were compared between cases and controls.
Antibody titers to trivalent influenza vaccination given during the 2011-2012 season were determined before and @number@ weeks after vaccination.
Anticancer effects of metformin have been discussed and many clinical trials are on-going.
Anti-carbamylated human albumin ( CarALB ) antibody was detected by in-house ELISA for @number@ RA patients and @number@ healthy controls ( HCs ) .
Anti-CCP and anti-TPO levels were below the detection limit of the assay.
Anticholinergic burden was defined using the Anticholinergic Cognitive Burden ( ACB ) scale.
Anticholinergic drugs were coded using the online database \ "Thesorimed \ ".
Anticholinergic drug use is common in older adults and has been related to increased dementia risk.
Anticholinergic exposure was defined using the Anticholinergic Drug Scale ( ADS ) .
Anticholinergic exposure was measured using the DBI-ACh and the ADS.
Anticholinergic load was determined for each patient using the Anticholinergic Drug Scale ( ADS ) .
Anticipated and experienced factors influencing the implementation , and the efficacy of the implementation process , were investigated.
Anticipated minimum overall participation rate for medical evaluation is @percent@ ( 731 / 971 ) .
Anticipated stigma significantly predicted greater depression among older adults with low mastery , but not among those with high mastery.
Anticipated survival is one marker of perceived uncontrollable threats to health.
Anticipatory and compensatory postural adjustments ( APAs and CPAs , respectively ) , both , are known to be affected in the elderly.
Anticipatory reaching declined with increasing occlusion duration , but the adverse effects for longer occlusion durations diminished with age.
Anti-CMV therapy alone does not always achieve clinical response in UC even in cases with high-load PCR.
Anticoagulant or antiplatelet therapy were preoperatively done in @percent@ of IHD cases , @percent@ of Af cases.
Anticoagulant underuse and antiplatelet use have both decreased since DOAC marketing.
Anticytokine therapies improve control of brittle asthma , while bronchial thermoplasty is an option in refractory cases.
Anti-dementia drugs were used by @percent@ of patients with dementia.
Antidepressants are assuming a more-prominent and psychotherapy a less-prominent role.
Antidepressants are the mainstay of pharmacological treatment for clinically significant depression in the general population but evidence to support their use in dementia is mixed.
Antidepressants have been shown to reduce the risk of depression recurrence in adults , justifying prolonged antidepressant maintenance therapy for most if not all patients.
Antidepressant treatment in older depressed patients is efficacious , but differences in the effectiveness of different classes of antidepressants have not been demonstrated.
Antidiabetic biguanides such as metformin decrease glucose , insulin and IGF-1 level.
Antidiabetic biguanides such as metformin , which reduce hyperglycemia and hyperinsulinemia by decreasing insulin resistance , extend lifespan , and inhibit carcinogenesis in rodents.
Antidiabetic therapy was evaluated for @number@ months post-index.
Anti-diphtheria antibody levels decrease with aging , and frequent booster vaccinations are required to maintain herd immunity.
Antiemetic medications are often used for controlling chemotherapy-induced nausea and vomiting in cancer patient.
Antifungal prophylaxis and remission of cancer predicted better survival.
Anti-GBM disease was defined as positive anti-GBM antibodies in circulation and / or linear immunoglobulin G deposition along the GBM on kidney biopsy.
Antigen presentation by MHC class I molecules requires degradation of epitope source proteins in the cytosol.
Antigen-specific multifunctional T cells that secrete interferon-γ , interleukin-2 and tumour necrosis factor-α simultaneously after activation are important for the control of many infections.
Antihypertensive , antidiabetic , and antilipemic medications are effective in lowering elevated CAVI.
Antihypertensive drugs that inhibit the renin-angiotensin system have been shown to be effective for controlling blood pressure in adult and elderly patients.
Antihypertensive drug therapy should be considered in all aging hypertensive patients , as treatment greatly reduces cardiovascular events.
Antihypertensive treatment concerned @percent@ of the hypertensive individuals with most often a combination therapy.
Anti-incontinence procedures can be performed at time of colpocleisis for patients with coexisting stress incontinence.
Anti-inflammatory agents have marginal effect in improving insulin resistance.
Antiinflammatory approaches have been studied.
Anti-inflammatory therapy is indicated for the first phase of GO.
Antimicrobial results illustrated that the ANHCPS possessed superior antibacterial capability of killing pathogenic bacteria.
Antimicrobial susceptibility was assessed by Etest , broth microdilution ( BMD ) and VITEK @number@
Anti-Müllerian hormone ( AMH ) has become the ' molecule of the moment ' in the field of reproductive endocrinology.
Anti-Müllerian hormone ( AMH ) is a glycoprotein belonging to the transforming growth factors ( TGF-P ) .
Anti-Mu llerian hormone ( AMH ) is secreted from small antral follicles and its level is correlated to the ovarian reserve.
Antimuscarinic agents are first-line therapies for overactive bladder and are often used in the management of nocturia.
Antimuscarinic agents in combination with bladder training have been proven as safe and effective treatment in men with OAB.
Anti-neutrophil cytoplasmic antibody ( ANCA ) -associated vasculitis are predominantly diseases of older patients , frequently involving the kidney.
Antioxid.
Antioxid.
Antioxid.
Antioxid.
Antioxid.
Antioxid.
Antioxid.
Antioxid.
Antioxid.
Antioxid.
Antioxid.
Antioxid.
Antioxidant activity of its fruit and seed has been investigated.
Antioxidant capacity measured by ORAC is independent of age and sex.
Antioxidant compounds can provide protection from endogenous and exogenous oxidative stress by scavenging free radicals.
Antioxidant could counteract oxidation-induced protein degradation , indicating that REGγ-proteasome activity may be regulated by redox state.
Antioxidant foods and ingredients are an important component of the food industry.
Antioxidant proteins are substances that protect cells from the damage caused by free radicals.
Antioxidants can provide protection against oxidative injury to skin via \ "quenching \ " ROS.
Antioxidant supplementation is probably the best way to prevent or delay the age-related OA.
Antioxidant systems deteriorate during aging.
Antioxidant vitamins supplements have been suggested as a strategy to decrease the risk of age-related cataract development.
Antioxidative activities are likely among the mechanisms of the biological activities and physiological effects.
Anti-ox LDL antibodies level was significantly higher in the two oldest subgroups of males.
Antiphotoaging therapy aims to counteract these effects.
Antiplatelet resumption should be considered , especially in survivors with adequate blood pressure control and without CAA.
Antiproliferative activity was observed in the tumor cell lines MG-63 and HepG2 but not in the normal cell line WRL @number@
Antipsychotic drug prescriptions significantly differed among the dementia SCUs.
Antipsychotic medications and a variety of non-pharmacological interventions appear to be used concurrently in many care homes.
Antipsychotics are frequently used in elderly patients to treat a variety of conditions , including schizophrenia.
Antipsychotics are likely to be initiated after hospitalization for stroke.
Antipsychotics increase the risk of stroke by more than three-fold in patients with dementia.
Antiresorptives reduce the number of basic multicellular units ( BMUs ) remodeling bone and reduce the volume of bone each BMU resorbs.
Antiretroviral-associated metabolic complications include dyslipidemia , hyperglycemia , and loss of bone mineral density.
Antiretroviral drug-related and inflammation-related effects can cause mitochondrial toxicity and are an emerging area of research.
Antiretroviral therapy has been shown to enhance events seen in biological aging.
Antiretroviral therapy may not fully normalize this condition.
Anti-RNP antibodies were positive in serum and CSF.
Anti-Ro antibodies may be associated with neonatal lupus which causes heart blocks.
Ant is an abundant protein primarily involved in ADP / ATP exchange across the mitochondrial inner membrane.
Antisense oligonucleotides ( ASOs ) and RNA-interference approaches are emerging as attractive therapeutic strategies in neurological diseases.
Antistress biology is proposed for the first time as a preclinical practice or strategy for antiaging.
Anti-VEGF therapy for age-related macular degeneration was named as one of the top ten science advancements of the year @number@
Antiwrinkle effects were assessed through the inhibition of hyaluronidase , elastase , collagenase , and matrix metalloproteinase ( MMP ) -1.
Antral follicle count and anti-Mullerian hormone decrease with age and have been used to attempt to predict the length of the fertile window.
Antral follicle count and anti-Mullerian hormone have been shown to be the best indicators of a woman's total follicular reserve.
A @number@ cm increase in height is associated with a @number@ standard deviation increase in a summary cognitive score ( mean @number@ std. dev.
A @number@ hS significantly increased IL-8 levels by @number@ ng ( p = @number@ ) .
A @number@ items-quality score was calculated , ranging from @number@ ( lowest quality ) to @number@ ( highest quality ) .
A @number@ × @number@ factorial with repeated measures design was used.
A number of additional statistically significant associations were identified in bivariate correlation analyses.
A number of animal studies have been conducted to examine the role of sirtuins in ocular aging.
A number of associated factors were identified , which may provide targets for intervention to improve participation among older men.
A number of centrally acting neuropeptides have also been shown to modulate cognitive processes.
A number of clinical as well as biological studies have been pivotal in providing us with an understanding of the pathophysiology of this condition.
A number of clinical as well as translational studies have been pivotal in providing us with an understanding of the pathophysiology of this condition.
A number of different cellular sources of RPCs have been identified in the vertebrate retina.
A number of differentially expressed miRNAs were identified in each set of patient comparisons.
A number of different model organisms from yeast to monkeys have been studied to understand the aging process.
A number of drugs aimed at reducing this risk have been tested in randomized controlled trials.
A number of excellent scales or questionnaires are now available to measure music engagement.
A number of extraneous and potential confounding variables can affect the outcome of clinical research.
A number of factors complicate treating pain in the elderly.
A number of factors could mediate the exercise-cognition association , including depression , and social or cognitive stimulation.
A number of factors increase the risk for malnutrition in older people with cancer , including chronic comorbid conditions and normal physiological changes of aging.
A number of factors predict back pain presence in epidemiological studies , and these are often present , and predictive , at different life stages.
A number of frailty assessment tools have been recommended for use in primary care.
A number of genes associated with LTL have already been identified through genome-wide association studies.
A number of genetically defined accelerated aging diseases have been characterized that can aid in our understanding of aging.
A number of genetic disorders exist in man where a breakdown in genome maintenance is associated with cancer predisposition.
A number of genetic polymorphisms are related to individual differences in cognitive performance.
A number of health outcomes improved.
A number of important program elements were identified which if incorporated into prevention programs , may help to address the rising burden of falls.
A number of inter-related themes emerged within each construct.
A number of issues need to be addressed before this approach is ready for translation into routine clinical practice.
A number of mechanisms may contribute to frailty.
A number of medical treatments for LUTS / BPH exist , such as α-blockers , 5α-reductase inhibitors , phytotherapeutical drugs and combination therapies.
A number of morphological and functional neuroimaging studies have offered additional evidence supporting the relationship between gait and cognitive resources.
A number of neuropsychological tests and the Interpersonal Support Evaluation List were administered.
A number of novel miRNAs were also identified , particularly in old muscle.
A number of novel technologies , however , have improved the noninvasive assessment of oocyte quality.
A number of nutritional formulations to improve deteriorating memory are being studied.
A number of open questions in human evolutionary genetics would become tractable if we were able to directly measure evolutionary fitness.
A number of other facility organizational characteristics unrelated to ownership were also associated with transfer rates.
A number of oxidative protein modifications have been well characterized during the past decade.
A number of participant burdens are unique to the elderly population.
A number of pharmaceutical grade stem cell products have also recently been tested and reported on.
A number of practical suggestions were also drawn from the articles reviewed.
A number of previous studies have examined the effect of estrogen on hippocampal structure to determine the mechanism underlying estrogen effects on hippocampal function.
A number of prior animal studies suggested that HRT may be neuroprotective and cardioprotective.
A number of randomized clinical trials with adequate methodologies observed neutral or negative results of antioxidant supplements.
A number of ROS-scavenging substances and procedures were described without however reaching credibility for their therapeutic value.
A number of small molecule compounds activating these signaling cascades have been described.
A number of small molecules with the ability to extend the lifespan of multiple organisms have recently been discovered.
A number of small studies and anecdotal reports have been suggested that sports involving repeated head trauma may have long-term risks of neurodegenerative disease.
A number of structural changes occur in the kidney with aging.
A number of studies did not find health literacy to explain health behaviors whereas other studies supported such a relationship.
A number of studies have been focused on chemo-preventive use of resveratrol as antioxidant against cardiovascular diseases , aging and cancer.
A number of studies have documented that insulin directly affects brain processes and that reduced insulin signaling results in impaired learning and memory.
A number of studies have estimated the heritability of LTL , but none has assessed the heritability of age-dependent LTL attrition.
A number of studies have examined dietary patterns in various populations.
A number of studies have explored and reported on existing comorbidities between SD and medical conditions for which urological problems are no exception.
A number of studies indicate that the molecular mechanisms causing accelerated aging in progeric patients also occur in healthy cells of older individuals.
A number of studies reported a relation between longevity , oxidative stress and age-related diseases.
A number of techniques such as scanning electron microscopy , transmission electron microscopy and confocal microscopy have been used to study hair surfaces.
A number of these genes , including CLU , C3 , and CD74 , have been implicated in beta amyloid generation or clearance.
A number of these overlapping effects involve changes in mitochondrial function.
A number of tissues and organs in the human body contain abundant proteins that are long-lived.
A number of tools are available but the psychometric quality and clinical utility of these are uncertain.
A number of transgenic models expressing wild-type and mutant forms of the 4R Tau have been developed.
A number of variables were employed to identify individuals with MHD , including prescribed medication , self-reported diagnoses and self-report scales.
A @number@ T MRI examination was conducted under three conditions : rest , PFM MVC , and straining.
A @number@ to @number@ fold signal improvement in microneedle enhanced delivery of melanostatin , rigin and pal-KTTKS was observed.
A @number@'-untranslated region containing the predicted target sequences from each gene was placed individually in a luciferase reporter construct.
A numerical optimisation procedure is used to determine the stiffness parameters that provide a best fit between the finite element model and the experimental data.
A NUMT suppressor gene was identified by comparing numtogenesis in other organisms.
An unadjusted model was run to examine the relationship between independent and dependent variables.
An unbiased longitudinal voxel-based morphometry approach , based on high-dimensional spatial alignment within-subject , was applied to the serial imaging data.
An unbiased screen for compounds that block amyloid-β protein precursor ( AβPP ) caspase cleavage identified ADDN-1351 , which reduced AβPP-C31 by @percent@.
An understanding of circadian skin-related functions and the impact of their disruption allow clinicians to improve therapeutic decision-making and maximize the effectiveness of prescribed treatments.
An understanding of dementia requires sensitivity to the complex breadth of factors that comprise the person's experiential and social context.
An understanding of RBM development is critical to understanding the extent and time of appearance of its abnormal thickening that is characteristic of asthma.
An understanding of risk factors predicting repeat vertebral augmentation provides valuable basis to improve health care for geriatric populations.
An understanding of the different products , the injection techniques , the indications , and the potential complications of each filler are paramount to success.
An understanding of the physiology of androgens in the ageing man is essential for the appropriate diagnosis of LOH.
An understanding of the risk factors acting during development is particularly limited.
An understanding of the role that IL-7 plays in aging may permit parsimonious preventative or therapeutic solutions for diverse conditions.
An understanding of these factors maybe instrumental to determining future directions for research to maximize positive outcomes for these patients.
An understanding of these modifications is still in its infancy.
An unexpected effect on cultured dermal fibroblasts , during an experimental study on the gene activation in aesthetic bio-stimulation , was observed.
An unexplored question is whether and how emotion recognition in music changes as a function of ageing.
An unpaired t-test was performed using statistical analysis software.
An unusual feature in this case included prominent melanocytic proliferation with associated nuclear atypia and increased mitotic activity.
An updated search was done on @date@ .
An update is presented on information regarding pathophysiology , diagnosis , management , and future directions in this important and growing disorder.
An upper limit of normal for 17-hydroxyprogester-one of @number@ nmol / L was established by analysing a cohort of samples from unaffected newborns.
An upright upper trunk in Fowler's position might help to reduce orthostatic stress and facilitate routine activities and conversation in frail patients.
Anxiety and depression were significantly associated with subjective memory concerns.
Anxiety and depressive symptoms were measured using the Hospital Anxiety and Depression Scale.
Anxiety and worry were assessed through items of the instrument Pediatric Quality of Life Inventory™ Cancer Module Scale.
Anxiety , depression , somatic , cognitive symptoms were more prevalent in females while anger hostility was more common in males.
Anxiety disorders were determined with the Munich version of the Composite International Diagnostic Interview.
Anxiety , irritability , and appetite / eating were not associated with increased risk of incident dementia.
Anxiety is a major cause for distress among older people with dementia , and it impedes care.
Anxiety phenotypes are consistent with other α-synuclein based PD models yet incongruous with typical clinical symptoms.
Anxiety produces maladaptive cardiovascular changes and accelerates biological aging.
Anxiety sensitivity and intolerance of uncertainty partially mediated the relation between age and health anxiety.
Anxiety symptoms were additionally linked to greater decline in executive function , irrespective of beta-amyloid and other risk factors.
Anxiety was correlated with more individual domains of QOL than depression.
Anxiety was higher on occasions when social support networks were smaller and when more stressful life events were experienced.
Anxiety was strongly associated with dizziness , whereas other associations were of marginal importance.
Any advances that hold out the realistic prospect of tackling age-related morbidity are therefore to be welcomed.
Any adverse events in particular post inflammatory hyperpigmentation or hypopigmentation were not seen in any of the patients.
Any adverse events related to the treatments were monitored.
Any amount of exercise is better than being sedentary , even if health status prevents a person from achieving recommended goals.
Any anaemia expresses the existence of a pathological process , regardless of its severity.
Any associations to antero-posterior cephalometric characteristics seem low.
Any biological consequence of this form of instability remained obscure until quantitative modeling revealed a link between elevated T-SCE rates and accelerated cellular replicative senescence.
Any cataract was defined as any unoperated or operated cataract.
Any change in reproductive norms tends to generate concern.
Any chronic pruritis or persisting blister in old people should lead to the diagnosis procedures of a bullous pemphigoid.
Any compositional change in the gut is directly linked to gastrointestinal disorders , obesity and metabolic diseases.
Any correlation between the changes in the cell properties with cell aging is also not clear.
Any correlations between the laboratory data and the telomere length parameters were assessed.
Any correlations between the laboratory data and the telomeric parameters were assessed.
Any disruption in the supply of energy results in various abnormalities including Alzheimer's disease ( AD ) , a condition with markedly diminished cognitive ability.
Any factor that is capable of causing these events is potentially a risk factor for AD.
Any guideline representing a consensus for aesthetic treatments using botulinum toxin type A ( BTA ) in Asians has not been published.
Any increasing score of the Short Portable Mental Status Questionnaire in the observational period was referred to as cognitive function decline.
Any information related to the effects of ageing factors is called an observation and is presented on observation pages.
Any initiative that involves supporting the older patient ( > 65years ) at mealtimes is beneficial.
Any interaction with @number@ major predisposing diseases - diabetes and arterial hypertension - has not been shown.
Any liraglutide-related cholelithiasis case has not been reported in the literature previously.
Any loss of skeletal muscle mass must be underpinned by a chronic imbalance between muscle protein synthesis and breakdown rates.
Any microflora needs nutrition and perceives the human body only as a nutrient substrate.
Any movements toward healthcare reform must focus on improving outcomes per healthcare dollar spent , and increasing value.
Any negative reported effects on sexuality are more likely due to anticipation or negative representations of sexuality around menopause than to biological or hormonal effects.
Any order in variation is attributed to epigenetic or developmental constraints that can hinder the action of natural selection.
Any particular placental phenotype seems to predict a limited number of diseases.
Any part of the skin is possibly altered , including the epidermis , dermis , hypodermis , and hair follicles.
Any pathology report should be concise and delineate only the essential features.
Any previous treatment was recorded , and necessity of retreatments and side effects was evaluated.
Any primary care doctor should be able to decide on the fitness to drive of a given patient.
Any primary study described in these SRs with experimental design was included.
Any primary study with experimental design was then identified and included.
Any proposed cardiac operation in octogenarians mandates careful consideration of resource utilization.
Any research group , in France or elsewhere , can submit a research proposal to work on the GAZEL cohort.
Any strategy for case finding should be informed by understanding the characteristics of the undiagnosed population.
Any subsequent falls , any injurious falls and the number of falls were reported @number@ years later.
Any such association could explain , at least in part , the cardioprotective effects attributed to fiber intake.
Any type of surgery should be done as fast as possible after fracture as long as general condition of the patient is preserved.
Any unoperated cataract was based on these criteria or ungradable dense opacities.
Anyway , the presence of telocytes ( TCs ) has been overlooked , since they were described in @number@ ( visit www.telocytes.com ) .
Anyway , these individuals seem to have a reduced susceptibility to dementia , as well as to cardiovascular events.
AoA ratings were associated with the raters ' social or language status , but not with the raters ' age or education.
AOH was not associated with higher CES-D scores ( unstandardised B coefficient = .162 ; @percent@ CI @number@ @number@ p = @number@ ) .
A one-factor ( group ) , one-covariate ( age ) multivariate analysis of covariance was performed.
A one-way analysis of variance ANOVA was used to test for differences measured in points between individuals by quarterly birth year intervals.
A one-way analysis of variance was used to compare sleep quality and glycemic control for women with and those without nocturia.
A one-way analysis of variance with repeated measures on condition was performed for each postural control measure.
A one-way multivariate analysis of covariance ( MANCOVA ) using SPSS ( version @number@ ) was used in data analysis.
AON Tau∆Casp6 levels correlated with entorhinal cortex Casp6 activity and PHF-1 levels.
AoPWVestim differed from aoPWVinv by no more than @number@ m / s across all age groups.
AoPWVinv predicts subclinical organ damage better than cfPWVs , and as good as aoPWVestim.
AO risk was modelled by logistic regression.
Aortas of old mice , characterized by increased senescence , showed an increment in ASncmtRNA-2 expression.
Aortic AI corrected for heart rate and blood pressures were generated from pressure wave analysis ( SphygmoCor ) .
Aortic AI corrected for heart rate did not differ in the @number@ groups.
Aortic arch aneurysm occurs more commonly in the aging population.
Aortic atherosclerosis may explain , at least partly , in some high risk populations , the J-shape of the already reported DBP-outcome relationship.
Aortic distensibility ( AD ) decreases with age and increased aortic stiffness is independently associated with adverse cardiovascular outcomes.
Aortic geometries were obtained by magnetic resonance imaging , and the aortic blood flow field was computed using computational fluid dynamics.
Aortic pulse pressure , distensibility and aortic wall stiffness index were calculated offline.
Aortic-pulse wave velocity by applanation tonometry and albuminuria ( from three timed urine collections ) were also measured at baseline and @number@ weeks.
Aortic pulse wave velocity ( PWV ) is an independent determinant of cardiovascular risk.
Aortic PWV was estimated ( aoPWVestim ) from single-point radial waveforms , age , and SBP.
Aortic root diameters were also tested and compared between the end-diastole and the mid-systole.
Aortic root dilatation remained stable during follow-up in this population receiving β-blocker therapy.
Aortic root was stained for fatty and fibrotic deposits and for the expression of aP2 and VCAM-1.
Aortic size was larger in every segment of the dissected with respect to non-dissected aortas ( p < 0.001 ) .
Aortic stenosis ( AS ) is common and is the commonest reason for valve surgery in the Western hemisphere.
Aortic stenosis is currently the most predominant valvular pathology in older adults.
Aortic stenosis is the most common valvular heart disease in Europe and North America and it is a real public health problem.
Aortic stenosis is the most frequently acquired heart disease , and the prevalence is rising because of the aging population.
Aortic stenosis is the most predominant valvular pathology occurring in older adults with an expected increase over time.
Aortic stiffness , a cardiovascular risk factor , depends on the operating mean arterial pressure ( MAP ) .
Aortic stiffness can be estimated non-invasively by applanation tonometry with carotid-femoral pulse wave velocity.
Aortic stiffness is a marker of the alteration of structural and functional properties of the wall of the large arterial trunks.
Aortic stiffness is strongly related to age and mean arterial pressure ( MAP ) .
Aortic stiffness was assessed during the @number@ visits by measuring carotid-femoral PWV.
Aortic stiffness was evaluated as the product of Young's modulus and aortic wall thickness.
Aortic strain and distensibility decreased with age , whereas the β stiffness index increased at all aortic segments.
Aortic valve area of the polymeric valves was measured , and the severity of stenosis was defined according to the clinical guidelines.
Aortic valve calcification was the predominant AS etiology , and its prevalence greatly increased with age.
Aortic valves are comprised of highly organized extracellular matrix compartmentalized in cusp and annulus regions , which have different functions.
Aortic valve stenosis ( AS ) increasingly afflicts our aging population.
Aortic valve stenosis has become increasingly prevalent , in agreement with the aging of the population.
Aortic valves were isolated from juvenile , adult and aged adult C57BL / 6 wild type mice.
AOx alone protected against ssUVR-induced hyperproliferation , as shown by epidermal thickness and CK16 biomarkers , and was better than SS alone.
AOx plus SS gave better protection against pigment formation and CK5 / 6 induction than SS alone.
AP-1 is a dimeric complex that primarily contains Jun and Fos family members.
APACHE II score was higher ( P < @number@ ) in the non-HR group.
APA error was increased in response to the flanker task and step execution time was shortened with a speed strategy compared to an accuracy strategy.
A pain behavior tool can also provide useful information suggesting the presence of pain.
A paired t-test was applied for each category comparing the pre treatment and 3-month post treatment results.
A paired t test was used to analyze the difference between pretreatment and posttreatment values at each study time point.
A paired t-test was used to test for significant differences in bone turnover markers , oxidative stress parameters and antioxidant status after lycopene restriction.
A pair of experiments assessed whether such differences would extend to tasks with reduced working memory demands and time pressures.
A panel of nine experts in geriatric research and gerontological care evaluated the translation and the face and content validity of the instrument.
A paper published in this issue of Aging describes that the telomere protein tankyrase @number@ regulates DNA damage responses at telomeres.
A paradigmatic example of unifying Bio-Medical theory is the concept of Inflammaging.
A paradoxical negative association between obesity and the plasma B-type natriuretic peptide ( BNP ) level has been firmly established.
A parametric design procedure based on numerical simulations was implemented to identify design parameters providing acceptable stress levels and maximum coaptation area for the leaflets.
A parent's aging calls for a redefinition of parental care practices and roles in light of his or her own changing needs.
A parsimonious risk score was developed on the basis of beta estimates derived from the logistic model.
Apart from aerobic glycolysis , cancer cell growth is dependent on glutamine ( Gln ) supply , leading to their survival and differentiation.
Apart from age , the presence of active BAT is decreased in males and overweight.
Apart from APOE status , variation in the FOXO3A gene is the only confirmed genetic contributor to survival into old age.
Apart from being an accelerator of AD , T2D is associated with a progressive cognitive decline.
Apart from common synonymous variation , no sequence variants in UBQLN2 were observed.
Apart from demographics and the APOE genotype , only midlife dyslipidemia was associated with amyloid deposition.
Apart from environmental factors , genetic factors can influence mercury toxicity and explain part of the individual vulnerability.
Apart from Fe , Mn , and F , all tested elements and the pH were within national standards and World Health Organization guidelines.
Apart from foods with health claims ( including dietary supplements ) , medical foods are also being explored as an intervention option.
Apart from inflammation , NF-ĸB can regulate autophagy by inhibiting Beclin1 , an initiator of autophagy.
Apart from methodological issues , other biological factors are likely involved in this direction reversal.
Apart from microglia other brain resident and peripheral immune cells including pericytes , perivascular macrophages , mast cells and T-cells also modulate this phenomenon.
Apart from oocyte donation , there is no known intervention to improve the pregnancy outcome of older patients.
Apart from such quantitative changes , the efficacy of the related peptides may also change with age.
Apart from the common pathophysiological mechanisms , however , the two entities have several clinical links.
Apart from the costs of ageing and care , such fear creates intergenerational conflicts.
Apart from the geographical influence , other socioeconomic factors play a significant role in the evolution of the renal biopsy pattern.
Apart from them , so called stochastic aging connotes cell damage caused by metabolic processes , free radicals and cosmic irradiation.
Apart from these technological solutions , there are numerous environmental interventions in the home environment that can support people to age-in-place.
Apart from the treatment of numerous specific somatic problems , both psycho-oncological care and social-medical consultation and evaluation are centrally important tasks.
Apart from this , self-rated health and self-reported depression were associated with limitations in ADL.
Apart from this , the issues related to ongoing supply of consumables and human resources continue to be a challenge in these countries.
A participant guide and the use of a simple tool to ensure decision making capacity , are recommended.
A participant was classified prefrail when @number@ to @number@ criteria were met ; frailty was classified as the presence of @number@ or more criteria.
A particular attention was paid to eliminate the concomitant alcohol or psychotropic co-ingestions.
A particular emphasis is placed on the use of fractional , radiofrequency , microdermabrasion , laser-assisted lipolysis , and ultrasound devices.
A particular focus has been directed towards identifying persons at high risk of fracture.
A particular focus is given to the relationship between urinary and bowel dysfunction.
A particular focus of these studies is group differences and identification of participants at risk of deteriorating to a worse diagnosis.
A particular focus was on ontologies , because these are a key technology to systematically integrate heterogeneous information about the aging process.
A particular issue is to establish reference values for biomarkers in infants and children at different ages.
Apartment size was positively related to life satisfaction in the young-old but was negatively related in the old-old.
A partnership of BMT , IST , and basic science researchers will develop initiatives and partner with advocacy and funding organizations to address these challenges.
APAs have four core components that function to accelerate the center of mass forwards and towards the initial single-support stance limb.
A passive acoustic PPI paradigm was applied in @number@ subjects ; @number@ carriers of the fragile X premutation , and @number@ healthy controls.
A passive listening paradigm was used.
APAs were recorded by electromyography ( EMG ) , center of pressure ( COP ) , and kinematic measurements.
A path analysis confirmed the hypothesis that cognitive function is associated with occlusal force directly as well as indirectly via food intake.
A path-analytical approach was used to investigate moderating effects of age and gender.
A path model analysis was used to identify factors associated with intent to participate in assessment / multifactorial interventions.
A path model was used to study the associations of the profiles with unmet physical activity need.
Apathy and depression are the most common neuropsychiatric symptoms in mild cognitive impairment ( MCI ) and Alzheimer disease ( AD ) .
Apathy and depression were found to be particularly high in participants with AD and high motivational abilities.
Apathy , but not depression , increased over time in those with AD and high motivational abilities.
Apathy is a common neuropsychiatric symptom in Alzheimer's disease dementia and amnestic mild cognitive impairment and is associated with cortical atrophy in Alzheimer's disease dementia.
Apathy is associated with impaired neuropsychological functioning in individuals with HIV.
Apathy is common in aging and generally defined on the basis of three dimensions : lack of initiative , lack of interest and emotional blunting.
Apathy should be screened for as a potentially preventable cause of functional decline in clinical psychiatric settings.
Apathy was assessed using @number@ items from the Geriatric Depression Scale.
Apathy was assessed with the Apathy Evaluation Scale and was significantly associated with highest HIV plasma level , functional disability , and neurocognitive performance.
Apathy was assessed with the Apathy Scale.
Apathy was considered present if a score of ≥14 on the Apathy Scale.
Apathy was hetero-evaluated with the Apathy Inventory ( AI ) , a scale widely used to assess the apathy dimensions in aging.
Apathy was independently associated with older age , male gender and more severe depression.
Apathy was quantified using the Apathy Evaluation Scale.
A Patient Activation Measure ( PAM ) assessed self-management.
A patient-centered approach aimed at reducing the disability and social isolation of advancing age is mandatory to improve HR-QOL in any class of obesity.
A patient diary documented digestive symptoms and adverse events were recorded.
A patient presenting to a facial plastic surgeon with lower eyelid aging often has accompanying midface descent.
A patient showed invasion in the lymph nodes and was treated with hormonotherapy.
A patient was categorised as non-adherent if the me an adherence rate for all drugs consumed was \ \ 80 %.
Apatites of hard tissues of teeth of persons of different sex and age were studied in detail.
A paucity of high-quality studies examining anticipatory postural control supports the need for further research in this area.
A paucity of research exists to investigate whether the normal aging process influences the ability to adapt disparity vergence and phoria.
APC-2 , a protein crucial to cell division , initiates anaphase by triggering the degradation of multiple proteins.
A PCA factor representing the anterior N2 , sensitive to novelty , exhibited age-related amplitude decreases.
APCC doubled initial clot growth velocity , although even more in the absence of dabigatran.
APE1 also has @number@'@number@ DNA exonuclease and @number@ DNA phosphodiesterase activities , and regulates transcription factor DNA binding through its redox regulatory function.
APE1 levels in sera of @number@ healthy donors were also determined as control.
A peak age for detecting and studying the earliest fundamental biological underpinnings of autism is prenatal life and the first three postnatal years.
A pedigree-based heritability analysis of Δage was conducted in a separate cohort.
ApEn and spikiness correlated positively with age , especially in men.
ApEn in the elderly , especially men , is increased , pointing to a less tight feedback control.
A perceived lack of evidence for benefit and safety concerns may lead to underprescription of HMG-CoA reductase inhibitors ( statins ) in older adults.
A @percent@ confidence interval ( CI ) and a @percent@ significance level were established for all the tests used.
A @percent@ increase in MAR was associated with a @percent@ decrease in CRP.
A @percent@ increase in peak strain was observed for the 80-year-old as compared to the 50-year-old during exhalation.
A @percent@ increase in the AA-incidence reveals changes in HZ rates beyond those expected by population shifts.
A @percent@ increase in the infant mortality rate is associated with a @number@ standard deviation decrease in the summary cognitive score.
A @percent@ of the elderly had the strongest opinion regarding the use of herbal medicines as substitutes for conventional medicines.
A @percent@ significance level for the univariate analysis was used to identify variables in the multivariate model.
A @percent@ variability in OTE is attributable to the region in question.
A perfect cure may yield EVA of @number@.6B per yr.
A perifoveal ring of high AF mirrors rod photoreceptor topography and fundus-AF.
A period of fast and slow growth of the eye can be discerned.
A period of post-learning sleep benefits memory consolidation compared with an equal-length wake interval.
A period of right lateralisation was identified in response to long lines in young adults , which was not present for short lines.
A persistence of areas of lower and higher occurrences of long-lived subjects was observed across time.
A persistent risk of shunt failure was observed well into adult life.
A person-centered approach is critical to identify the health heterogeneity of elderly people and manage their care needs by targeting differential aging.
A person-centred approach to health- and social care delivery is efficient and improve outcome for the recipient of care.
A person's ability to be independent is dependent on his or her overall health , mobility , and ability to complete activities of daily living.
A perspective will be provided based on the analysis of information under review.
A phantom of fat-water mixtures was established to test the accuracy of the sequence.
A pharmacist-led HMR service was significantly associated with the prescribing of all @number@ EBTs.
A pharmacokinetic model for paracetamol characterizing changes in pharmacokinetic parameters across the pediatric age-range was developed.
A pharmacological inhibitor of JNK attenuated this phenotypic shift in vitro , demonstrating involvement of JNK signaling in this process.
A Phase III clinical trial on osteoporosis showed that eldecalcitol reduced the incidence of new vertebral fractures over @number@ years by @percent@ compared with alfacalcidol.
A phase III randomized study , testing short-course adjuvant radiotherapy with or without temozolomide in elderly patients with good clinical status , is ongoing.
A Phase III RCT is currently being conducted to determine the effectiveness of iCST.
A Phase @number@ trial is underway to confirm these preliminary results.
Aphasia severity correlated with connectivity in the left working memory network within lvPPA.
A phenomenological qualitative method was used in this study.
A phenomenological study was conducted , using Giorgi's phenomenological method.
A phenotype of frailty according to partially modified measurement of Cardiovascular Health Study criteria was operationalized.
A photosensitive derivative of the visual pigment , ( A2E ) , may be involved in this phototoxicity.
A PHV was closely associated with the patient's number of frailty characteristics.
A Physical Activity Scale for the Elderly ( PASE ) was used to determine level of physical activity.
A physically active lifestyle , especially engaged in NLTPA , is associated with lower mortality risk in the elderly population.
A physically active lifestyle keeps both the vasodilator response and microvascular density high.
A physician evaluation is required for license review.
A physician will need basic abilities to communicate with an elderly for whom the use of a hearing aid may be problematic.
Apical periodontitis was found in @number@ ( @percent@ ) teeth treated for root canals.
Apical vertebral translation increased by @number@ mm ( p = @number@ ) annually in the GMFCS level IV-V group.
Apicodental synchondrosis and chondrum terminale were completely ossified after @number@ years ( range @date@ @number@ years ) .
A PIDP was defined according to the most recent update of the Beers criteria.
A piece of tasteless gum weighing @number@ g was used.
Apigenin can attenuate inflammation , which is associated with many chronic diseases of aging.
Apigenin ( @number@@number@ , -trihydroxyflavone ) is a flavonoid found in certain herbs , fruits , and vegetables.
Apigenin suppressed the SASP in part by suppressing IL-1α signaling through IRAK1 and IRAK4 , p38-MAPK , and NF-κB.
Apigenin was particularly potent at suppressing the expression and secretion of CXCL10 ( IP10 ) , a newly identified SASP factor.
A pilot conducted prior to the onset of the study revealed high rates of inter-rater reliability.
A pilot project in the elderly.
A pilot study was conducted to assess the added value of the dwelling check for older adults.
A pilot study was conducted to test and confirm the DSL protocol.
A pilot test on eight men was carried out and showed that the men's health index is viable.
A pilot training program ( @number@ investigators ) determined reliability , and a 12-week multicenter survey study validated the GGS scoring method.
A pioneer in aging research , Jim is considered by many to be the father of modern gerontological psychology.
Apixaban was rated FORTA-A ( highly beneficial ) .
A placebo-controlled randomized pilot study was performed on five postmenopausal women aged from @number@ to @number@ years.
A plasmid-based reverse genetics system for human astrovirus type @number@ ( HAstV1 ) is examined.
A plate waste protocol was used to determine actual food intake.
A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process.
A plethora of scientific evidence globally suggests that large proportions of people have vitamin D deficiency and are not meeting recommended intakes.
A plethora of studies on this model show the complexity of the system.
APL externalization occurs in numerous events , and it is relevant for transplant medicine , immunity and cancer.
A PLMI ≥ @number@ ( @percent@ ) and PLMA ≥ @number@ ( @percent@ ) were both prevalent.
APLS should review their normal values for respiratory rate in infants and teenagers.
Apnea and rapid ventricular pacing are used to interrupt cardiac ejection during balloon valvuloplasty and prosthesis implantation.
ApoA1 , ApoA2 , ApoB , ApoC3 , ApoE , ApoH , and ApoJ decreased from mid-life , although ApoE and ApoJ had U-shaped trends.
ApoA-I level was more readily detected in lipoprotein-deficient serum of the MetS group , indicating that the apoA-I exists in a lipid-free state.
Apo D is always expressed by neurons with no signs of degeneration or death.
ApoE4 , but not apoE3 , significantly increased brain Aβ half-life measured by in vivo microdialysis.
APOE-4 carriers showed a thinner entorhinal cortex in the left hemisphere when compared with the right hemisphere across all participants.
APOE4 carriers showed steeper hippocampal volume reductions with AD progression.
ApoE4 exerts a ' toxic ' gain of function whereas the absence of ApoE is protective.
APOE 4 genotype was associated with accelerated decline in language , memory , and executive functions.
ApoE4 increases brain amyloid-β pathology relative to other ApoE isoforms.
ApoE4 increases the risk of AD , possibly in part because it too changes DHA homeostasis.
ApoE4 is less prevalent in non-amnestic AD variants suggesting a direct effect on the clinical phenotype.
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease.
APOE4 may influence both brain DHA metabolism and cognitive outcomes.
ApoE4 showed an independent effect on hippocampal atrophy in MCI and AD and in the pooled sample.
APOE allele might play a role in the occurrence of cognitive impairment after mTBI.
APOE data were available for a subgroup of almost @number@ subjects.
APOE E2 status was not associated with change in cognitive performance over @number@ years.
APOE E4 allele carrier status did not interact with MTHFR genotype in affecting change in cognitive performance over @number@ years.
APOE e4 allele was coded as either present or absent.
APOE E4 / E4 carriers had lower Aβ42 levels ( p = @number@ ) .
APOE ɛ4 , the most significant genetic risk factor for Alzheimer disease ( AD ) , may mask effects of other loci.
APOE epsilon4 frequency was higher in all patient groups compared to controls.
APOE gene regulates the expression of this protein and has three different alleles : ε2 , ε3 and ε4.
ApoE genotype moderates the relationship between combat exposure and PTSD symptoms.
APOE genotypes were analyzed and biochemical parameters were tested.
APOE genotype was available in @number@ participants.
APOE genotype was determined from buccal cultures.
ApoE genotyping is considered critical in clinical trials of Alzheimer's disease.
APOE genotyping was available for @number@ of the participants.
APOE , HP , and CRYL1 have all been associated with Alzheimer's Disease , the pathology of which involves lipid and cholesterol pathways.
ApoE is involved in lipid and cholesterol transport , cell repair , and amyloid-β deposition and certain studies suggest potential implications in neurogenesis.
ApoE levels were significantly lower among ε4 homozygous individuals.
APOE methylation was negatively correlated with gene expression ( minimum r = @number@ P = @number@ ) .
APOE methylation was significantly associated with age ( minimum P = @number@.06E-08 ) and plasma total cholesterol ( minimum P = @number@.53E-03 ) .
ApoE plays a key role in the transport of cholesterol and other lipids involved in brain composition and functioning.
ApoE status , however , was not associated with PM performance.
APOE ε2 represents the first significant association for multiple subclinical atherosclerosis traits across multiple ethnicities , as well as clinical coronary heart disease.
Apo E ε2 scores predicted none of @number@ comparisons.
ApoEε4-carrier and aging are linked to enhancing ABCA7 risk-associated SAD.
APOE ε4 carriers also showed greater Aβ levels in several brain regions relative to ε4 non-carriers.
APOE ε4 carrier status showed a significant quadratic effect with age-related LTM decline in all models as previously reported.
APOE ε4 has in young adults been associated with better episodic and spatial memory , functions involving the aHC and pHC , respectively.
ApoE ε4 status was associated with a greater parahippocampal WM loss in both AD groups.
APOE-ε4 was associated with poorer odor threshold test scores.
A Poisson distribution was used to calculate age-adjusted fracture incidence rates , and Cox proportional hazards models for multivariable-adjusted hazard ratios.
A Poisson regression model was fitted with robust error variance.
A Poisson regression model was then performed , adjusting for age , sex , income , education and the diagnosis of a chronic disease condition.
A policy concern is the welfare of those individuals exiting the labour force before the age of pension eligibility.
A policy of penalizing hunters that harvest lactating females , however , may increase the harvest of 2-year-old females , which have high reproductive potential.
Apolipoprotein D ( ApoD ) , a member of the Lipocalin family , is the gene most up-regulated with age in the mammalian brain.
Apolipoprotein D ( Apo D ) is a lipocalin expressed in a wide variety of mammalian tissues.
Apolipoprotein E alleles have an important impact not only on AD but also on DHA homeostasis in humans.
Apolipoprotein E ( apoE ) is a lipid-associated protein present in both plasma and in central nervous system.
Apolipoprotein E ( APOE ) is the best-known susceptibility gene for AD.
Apolipoprotein E ( APOE ) ε4 has been associated with smaller hippocampal volumes in healthy aging , while findings in young adults are inconclusive.
Apolipoprotein E gene , a well-known risk factor for AD , was also found significantly associated with the disease in this study.
Apolipoprotein E genotype did not influence the observed effects of diabetes on cognition.
Apolipoprotein E genotype prevalence was significantly greater in the amnestic and nonamnestic subtypes of MCI.
Apolipoprotein E genotype was included as a covariate in these multivariable models.
Apolipoprotein E ε4 and parental family history of AD were not associated with higher burden of WMH.
Apolipoprotein levels trended lower in APOE ε4 homozygotes and heterozygotes compared with noncarriers , with ApoE and ApoJ being significantly lower.
Apolipoproteins play a crucial role in lipid metabolism with implications in cardiovascular disease , obesity , diabetes , Alzheimer's disease , and longevity.
A polymorphic variant of TOMM40 ( rs10524523 ) was included to differentiate between the effects of the APOE E3 and E4 allelic variants.
A polyphenol-rich diet may protect against frailty in older persons.
A polyurethane tube and glycerin solution were used to simulate a blood vessel and blood , respectively.
A pooled analysis of both study populations displayed similar or decreased sized P-values for most associations , hereby supporting the initial findings.
A pooled analysis of data from RE-COVER and RE-COVER II on DVT was used to reflect the probabilities for events in the cost-effectiveness model.
A pooled estimate was computed and differences between the pooled estimate and the coefficients were tested.
A pooled odds ratio ( OR ) with @percent@ confidence interval ( CI ) was used to assess the association.
A poor appetite in older adults is an important determinant of reduced food intake and undernutrition.
Apoptosis and autophagy are two evolutionary conserved processes that exert a critical role in the maintenance of tissue homeostasis.
Apoptosis and proliferation are the principal podocyte changes following injury with the latter leading to sclerosis and loss of nephrons.
Apoptosis and senescence are two types of cellular response to damages that are altered in both cancer and aging , albeit through different mechanisms.
Apoptosis , chondroptosis , necrosis , and autophagic cell death are described in this review.
Apoptosis induction is dependent on cytoskeletal changes , which depend on actin rearrangements.
Apoptosis inhibitor @number@ ( API-5 ) was found to be a potential regulator of miR-1 induced apoptosis , using a bioinformatics approach.
Apoptosis in the injured elderly subjects was significantly lower in all three time periods than the NIY.
Apoptosis is a genetically controlled and evolutionarily conserved form of cell death of critical importance for the maintenance of tissue homeostasis in the adult organism.
Apoptosis is a key mechanism to clear the immune system from activated and harmful cells.
Apoptosis is a programmed cell death process under both normal physiological and pathological conditions.
Apoptosis is a vital component in the evolutionarily conserved host defense system.
Apoptosis is such a regulated process , which is critically important in tissue homeostasis and development and leads to complete disintegration of the cell.
Apoptosis is the guardian of tissue integrity by removing unfit and injured cells without evoking inflammation.
Apoptosis was assayed on western probed for p53 , p21 , and caspase-3 and @number@
Apoptosis was detected using @number@ , ( DAPI ) staining , agarose gel electrophoresis and flow cytometry.
Apoptotic phospho-JNK , phospho-JNK / JNK ratio , and Bcl-2 were significantly elevated in AD subjects.
A population survey was conducted in @number@ participants ( mean age , @number@ years ) .
A position generator was used to collect network data on social capital.
A positive and moderate correlation was found between age and the activity of stair climbing ( r = @number@ p < @number@ ) .
A positive association remained when replacing WC by ICO ≥ @number@ ( a nationally obtained ratio ) in ATPIII MetS definition ( ModATPIII ) .
A positive association was demonstrated in the left subthalamic nucleus and the left superior frontal gyrus.
A positive association was observed between physical activity and episodic memory for young adults but not for older adults.
A positive association was reported if an increase in the risk for readmission among disadvantaged patients was found.
A positive attitude towards telemedicine was expressed by @percent@ of those surveyed.
A positive body image increases confidence in social interactions , which contributes substantially to health , well-being and quality of life.
A positive but non-linear relationship was found between country GDP and multimorbidity prevalence.
A positive correlation between CD3CD4CD25highCD127low and CD4HLA-DR was observed and gamma delta T cells were significantly decreased in the asthmatic patients compared to the controls.
A positive correlation between pain scores and negative affective state scores was also found , especially in cognitively impaired patients.
A positive correlation was also observed between hcy levels and FAQ scores , however this was not found to be significant.
A positive correlation was found between calcium score and number of fractures.
A positive correlation was found between the Crus II-vmPFC connectivity and performance on the Hopkins Verbal Learning Test-Revised delayed memory recall.
A positive ECG was defined by our Stanford Computerized Criteria as exceeding the 99th percentile for Q wave area in @number@ or more leads.
A positive effect of unemployment on temporal variation in middle-aged suicide exists but not for other age groups.
A positive effect was found in three out of six studies on functional status and in two out of four studies on quality of life.
A positive family history of PPOI is found in @percent@ of women with PPOI , indicating the existing genetic etiology.
A positive family history was defined as at least one relative with breast cancer or ovarian cancer or breast cancer in personal history.
A positive history of lifetime depression without current depressive symptoms was solely associated with naMCI ( @number@ ( @number@.99-1.73 ) ) .
A positive linear relationship was observed between IIEF-5 scores and total SF-36 score ( r = @number@ p = @number@ ) .
A positive linear trend exists between tissue thickness and age for Mi'kmaq males and females at multiple landmarks.
A positive reaction to MMPs was shown as different brown staining intensity in the cytoplasm of keratinocytes / tumor cells.
A positive relationship existed in the left claustrum and left thalamus.
A positive residual reflected better outcomes than expected for a given level of pathology ( high resilience ) .
A positive trend in participants ' perspectives on technology was evident along with a marginal increase in perceived independence.
A positive trend of marginal significance between quintiles of a dietary pattern with high consumption of meat and high CRP levels was also observed.
A positive zeta-potential was verified for half a year and longer.
A possibility of such effect inheritance in the asexual and sexual reproduction is shown.
A possible cause of the anorexia of aging is an age-dependent decrease in circulating acyl-ghrelin levels.
A possible contribution is proposed for Klotho levels in the development of central nervous system pathologies including mental disorders.
A possible effect of anti-epileptic or neuroleptic drugs was also detected.
A possible explanation for the difficulty in gene identification is that LOAD is a multifactorial complex disorder with both genetic and environmental components.
A possible explanation of vascular senescence process is the mitochondrial damage and dysfunction.
A possible mechanism for this would be that the overexpressed Gnaq inhibits the cellular damaging effect mediated by NF-κB and Erk1 / 2 signal pathways.
A possible method for estimating adequate Cr to be provided IV is to calculate the amount physiologically absorbed in healthy people.
A possible occupational context should always be considered.
A possible protective resource is ' Meaning in Life'.
A possible proton translocation mechanism with all membrane subunits operating in unison is described.
A possible scenario , which our experience leads us to favour , is that sIBM may start with inflammation within muscle.
A postal questionnaire was used to collect data from a stratified sample of the population @number@ years and older in southeastern Sweden.
A postal survey was used to assess knowledge of and intentions to use Internet-delivered mental health treatments.
A posterior dietary patterns derived by FA were not associated with risk of incident stroke in either men or women.
A post-hoc analysis of the @number@ AD subgroups showed no significant differences in serum hs-CRP level between each group.
A post-hoc analysis of the @number@ PD subgroups showed no significant differences in serum hs-CRP level.
A post-mortem brain was scanned in a clinical 3T MR system in situ.
A potential alternative to conventional postoperative radiotherapy after BCS in the future is the intraoperative radiotherapy technique.
A potential contributing factor may include air pollution exposures , which have been shown to increase systemic inflammation and affect erythropoiesis.
A potential developmental trend in performance is linked to a measure of motor function.
A potential for reversibility may also characterize this entity.
A potentially protective pathway was also identified wherein bisexuals had larger social networks after adjusting for other factors.
A potential mechanism by which pain affects mobility could be through its negative impact on the brain.
A potential resolution to this conundrum is that
A potential role of plasma Aβ concentrations as a marker of incipient dementia warrants further investigation.
APP and BACE2 are @number@ genes located in chromosome @number@ and related to AD.
Apparent defects in chromatin structure accumulate with age , the biggest single risk factor for cancer.
Apparently , cholinergic features can be flexibly adjusted to the needs of a species or strain.
Apparently divergent findings are reconciled when TRT is correctly indicated.
Apparently , PC appear to be a smaller hurdle for utilization.
Apparently , such reprogramming is capable of completely resetting the epigenome.
Apparently , the cell has additional regulatory systems that limit its own capability of reacting to DNA damage.
Apparently , there is no special program of aging.
Apparent problems in comparing the available data were the heterogeneity of measures and cut-offs for grades of hearing impairment.
APP but not PRNP duplication is a significant cause of early onset dementia in the UK.
APPcc overexpression in CA1 and not in the dentate gyrus induced endogenous SET translocation and tau hyperphosphorylation.
APP contains tandem triple repeats of the GXXXG motif in its extracellular juxtamembrane and transmembrane regions.
Appearance and fusion of the secondary ossification centers was significantly earlier in our study than previously reported.
Appearance and the work invested in it by and for people with dementia are a neglected issue within dementia studies.
Appearance-based interventions have had some success in reducing smoking and sun exposure.
Appearance-based video education can be made easily accessible.
Appearance may also motivate dietary behavior change if it was established that dietary improvement had a positive impact on appearance.
Appearance of antibodies to HSP plays a role in immune reactions , which maintain chronic inflammation of periodontium.
Appendiceal diameter and wall thickness were correlated with patient age , sex , height , weight , and presence of enlarged lymph nodes.
Appendiceal diameter was normally distributed across the population but was not significantly associated with age.
Appendicular lean body mass ( ALM ) and whole-body fat mass were measured using dual-energy X-ray absorptiometry.
Appendicular lean body mass index ( AppLBMI ) and MQ ( knee extension strength / right leg lean mass ) were calculated.
Appendicular lean mass ( aLM ) and aBMD were also estimated using dual-energy X-ray absorptiometry.
Appendicular lean mass ( ALM ) was assessed using dual energy X-ray absorptiometry.
Appendicular lean mass ( aLM ) was calculated as the sum of lean mass in arms and legs.
Appendicular LM ( aLM ) was estimated using dual-energy X-ray absorptiometry ( DXA ) and this method served as the reference criterion.
Appendicular muscle mass , grip strength , and walking speed were stratified into quartiles in both genders to explore their associations with different hormones measures.
Appendicular Skeletal Muscle Mass / Height ( @number@ ) was calculated.
Appendicular skeletal muscle mass was estimated from bioimpedance analysis measurements and expressed as skeletal muscle mass index.
Appendicular skeletal muscle mass was estimated using dual-energy x-ray absorptiometry and calculated as the sum of lean mass of the @number@ limbs.
Appendicular skeletal muscle mass was measured using dual-energy X-ray absorptiometry , and bioelectrical resistance was measured using a multifrequency bioelectrical impedance analyzer.
Appetite decreased in young , while it increased in older ( P < @number@ ) .
Appl.
Application-based hearing screening was performed in a non-soundproofed quiet room , and subsequently all participants underwent full diagnostic audiometry in a soundproof booth.
Application in both benchmark data and an experiment studying aging showed robust performance.
Application of antioxidants such as lycopene has been demonstrated as a convenient way to achieve protection against skin aging.
Application of discrete mathematics to imaging data is introduced as a tool to develop pattern recognition of intracellular protein fibrillation.
Application of inhibitors of mitogen-activated kinases attenuated the ability of Klotho to interfere with apoptosis and senescence in endothelial cells.
Application of metabolic modulators caused significant changes in mitochondria membrane potential , intracellular ATP level and ATP : ADP ratio.
Application of @percent@ static stretch had no effect.
Application of the evaluation on LBP patients revealed prominent deviations from the healthy postural changes , suggesting potential clinical applicability.
Application of the framework is further illustrated through the use of clinical examples.
Application of the Naranjo algorithm found @percent@ definite , @percent@ probable , and @percent@ possible ADRs.
Application of the proteomic-based mass spectrometry by matrix-assisted laser desorption ionization-time of flight is also described.
Application of the US Food and Drug Administration's geriatric labeling rule provided further impetus.
Application of two-dimensional surface electrode arrays can provide a means of mapping motor unit action potentials on the skin surface above a muscle.
Application of voltage-operated Ca2 + channel blockers or Ca2 + chelators abolishes AS-mediated toxicity.
Application of wavelet transform coherence method provided time frequency distribution of the coherence between the two signals.
APPLICATION : Results can inform the design of telephone features to improve ease of communication for older adults.
APPLICATION TO CLINICAL PRACTICE : Long-term use of vitamin E and C supplements has no appreciable effect on cataract.
Applied to complex pharmacological datasets , VENNTURE's improved features and ease of analysis are much improved over currently available Venn diagram programs.
Apply appropriate preoperative and postoperative management for facelift patients.
Applying a multivariate approach , our results suggest that late-life developments in two key components of successful aging are intrinsically interrelated.
Applying antioxidants to attenuate skin photoaging has received great attention.
Applying a SLN algorithm does not impair the prognosis of endometrial cancer patients.
Applying a VOI-brain-mask including extracerebral regions gave robust PVEC , with increased precision of the SUVR results.
Applying Benjamini and Hochberg correction these associations could not be confirmed and also not be replicated in the more heterogeneous Milano sample.
Applying external validation , similar results were observed in the Rotterdam Study-II and the Chingford Study.
Applying logistic regression in our analysis , we related dietary patterns to the prevalence of AMD.
Applying strategies for clearing the AGEs proposed by de Grey may be more difficult in the highly mineralized extracellular matrix.
Applying this model , the current study examined proximal and distal variables associated with positive and negative affect in oldest-old adults , investigating age differences.
Applying what we know about brain function to both traditional and online teaching is easy.
APP manipulation and Aβ application , in vitro and in vivo , affect synapse formation and synaptic transmission.
APPPS1 transgenic mice develop amyloid-β @number@ ( Aβ42 ) -driven early-onset cerebral β-amyloidosis.
APP / PSEN1 mice displayed no behavioral impairment relative to WT controls.
Appraisal and synthesis was completed using MOOSE guidelines.
APPROACH : A MAIN RESULTS : No significant sex differences were observed in any of the age categories.
Approach and avoidance ratings differentially predicted recall across age groups , with stronger associations in the young.
APPROACH AND RESULTS : Fourteen cohort studies with tPA measures ( N = 26 @number@ ) contributed to the meta-analysis.
APPROACH AND RESULTS : The cohort consisted of @number@ subjects who underwent carotid IMT measurement.
Approaches range from drug discovery efforts to big-data methods and direct-to-consumer ( DTC ) strategies.
Approaches that account for dynamic age shifts in survival improvements appear to perform better than others that enforce relatively invariant patterns.
Approaches that take into consideration more personalized interventions may be critical to promoting healthy aging in people with TJR.
Approaches to care that promote a flexible approach to palliation alongside curative care could do much to improve the burden of living with severe COPD.
Approaches to deliver primary fracture prevention in a clinically effective and cost-effective manner are also explored.
Approaches to mitigate psychotropic medication use need to consider different prescribing habits observed in older women vs. men with AD.
Approaches to subtyping that also incorporate biomarkers increase diagnostic specificity and have greater predictive value.
APPROACH : Here we describe an in vitro platform for rapid evaluation of implant stability.
APPROACHING : Approaching concerns how people become closer to each other in a physical space.
Approaching flow limited this natural drift and receding flow enhanced it , as indicated by the VSQ.
APPROACH : We applied WHO's knowledge translation framework on ageing and health to assist evidence based policy-making in Ghana.
Appropriate allocation of resources for cancer prevention , early diagnosis , and curative and palliative care requires detailed knowledge of the local burden of cancer.
Appropriate analyses are lacking for cognitive behavioral therapy ( CBT ) with caregivers of people with dementia.
Appropriate application of ADSC for stem cells therapy of cardiovascular disease warrants knowledge of their mitochondrial phenotype and function.
Appropriate balance of these hormones within HT is important to avoid the negative consequences of body fluid and sodium retention , including edema and hypertension.
Appropriate dosing or optimal administration routes are in most cases unknown.
Appropriate inhibition in astrocytic IKKβ / NF-κB protected against chronic overnutrition impairing astrocytic plasticity and these physiological functions.
Appropriate knowledge of cardiovascular disease and cognitive decline risk factors ( RFs ) are critical for global CVR health preventive intervention.
Appropriate management of cardiometabolic profiles among older people may help improve cardiovascular health and achieve healthy aging.
Appropriate management of health risk factors to prevent silent cerebrovascular lesions may prevent higher level functional decline in the elderly population.
Appropriate methods of statistical analysis were used to compare data from baseline and follow-up evaluation.
Appropriate prescribing , preserving the balance between drug effectiveness and safety , and treatment adherence may prevent these ADEs.
Appropriate prevention measures should be developed to reduce the prevalence of VCI.
Appropriate randomized clinical trials are required to further assess any potential clinical efficacy and investigate the effects on in vivo inflammation.
Appropriate regulation of mRNA translation is essential for growth and survival and the pathways that regulate mRNA translation have been highly conserved throughout eukaryotic evolution.
Appropriate revisions of the pediatric triage system are suggested.
Appropriate statistical analyses were performed.
Appropriate treatment due to the positive diagnosis generally lead to satisfactory results , surgical intervention with indefinite causes is strictly prohibited.
Appropriate treatment requires that swallowing be assessed objectively.
Appropriate treatment strategies in this age group are currently undefined since it is unclear whether the benefits of immunosuppression exceed the risks.
Appropriate use of antithrombotic therapies and vascular closure device in patients at increased risk of ASC may improve post-PVI outcomes.
Approved IVIg products on the market differ regarding source of plasma , isolation process , and formulation.
Approximally @percent@ of fibromas are densely cellular with small amount of collagen.
Approximate average hospital charges for an inpatient surgical treatment were about twice those of the non-surgically treated patients.
Approximate entropy ( ApEn ) was calculated to assess the regularity of the movement , with the smaller value associated with the greater regularity.
Approximately 10-15% of acute strokes are caused by non-aneurysmatic intracerebral hemorrhage ( ICH ) and incidences are expected to increase due to an aging population.
Approximately after the 2nd PRP injection , significant decreases in SF total protein concentrations , volumes , and Lequesne index values were observed.
Approximately a @number@ point increase in the BDI score was observed for each additional decade of aging in hypertensive patients.
Approximately a quarter of unilateral courses were switched later to bitemporal placement , most probably because of insufficient progress.
Approximately half of all people living with HIV in the US are age @number@ and older.
Approximately half of the adults in each group were ApoE e4 carriers and half were noncarriers.
Approximately half of the increase in the world's population by @date@ be accounted for by the prolonged survival of those over the age of @number@
Approximately @number@ deaths due to drowning are reported annually , @number@ of which are reported in Europe.
Approximately @number@ h after a RES , all of the groups were given an oral fat tolerance test ( OFTT ) .
Approximately @number@ households were interviewed from each wave of both studies using a standardized survey questionnaire.
Approximately @number@ individuals were included in the analysis after removing individuals with confounding conditions.
Approximately @number@ million people in the United States have Alzheimer's disease ( AD ) , with the principal risk factor being age.
Approximately @number@ million people in the world live with a debilitating hearing loss.
Approximately @number@ million persons were estimated to have diabetes worldwide in @number@ an increase of @number@ million cases from @number@
Approximately @number@ % of nonagenarians reach @number@ years and beyond in good condition and seem to have a combination of both age-span and health-span.
Approximately @number@ participants including principal investigators , postdoctoral fellows , and graduate students were in attendance.
Approximately @number@ people suffer cardiopulmonary arrest in Japan every year , and the aging of society means that this number is expected to increase.
Approximately @number@ to @percent@ of these patients do not undergo surgical treatment and a high proportion is considered to be at high risk for surgery.
Approximately @number@ weeks later , @number@ ( @number@ young adults and @number@ older adults ) participants completed the correspondence bias task.
Approximately one-half of patients experienced long-term use of a tracheal tube and / or multiple operations for tracheal reconstruction.
Approximately one quarter ( 25·1% ) had evidence of had one or more drug-drug interactions.
Approximately one-third of participants on antidepressant or antianxiety medication still met criteria for an Axis I disorder.
Approximately one-third of patients are older than @number@ years at diagnosis.
Approximately @percent@ ( 222 / 518 ) of the subjects were male and @percent@ ( 338 / 518 ) were @number@ years or older.
Approximately @percent@ and @percent@ of youth in the highest and lowest BMI quintiles , respectively , remained in these quintiles as adults.
Approximately @percent@ ( n = @number@ ) of caregivers reported seeking information to help them care for their care recipients.
Approximately @percent@ ( n = @number@ ) of respondents reported at least one SSSR.
Approximately @percent@ of acute exacerbations of symptoms in COPD are caused by non-typeable Haemophilus influenzae , Moraxella catarrhalis , Streptococcus pneumoniae and Pseudomonas aeruginosa.
Approximately @percent@ of adults have foot ailments , and the prevalence increases with age.
Approximately @percent@ of ALS patients are familial ( fALS ) cases , and the remaining @percent@ are apparently sporadic ( sALS ) cases.
Approximately @percent@ of Americans consume less than the EAR for magnesium , and some age groups consume substantially less.
Approximately @percent@ of breast cancers are diagnosed in postmenopausal women.
Approximately @percent@ of cases were repeated measures of the same individuals 3-5 yrs later.
Approximately @percent@ of children had intermediate or poor total cholesterol levels.
Approximately @percent@ of macronutrient oxidation was determined by diet and @percent@ by intrinsic factors ( P < @number@ ) .
Approximately @percent@ of male infertility is idiopathic.
Approximately @percent@ of men treated for BPH have coexisting hypertension.
Approximately @percent@ of older cancer survivors met aerobic and muscle-strengthening guidelines , compared with @percent@ of middle-aged cancer survivors ( P = @number@ ) .
Approximately @percent@ of older Japanese people indicated that they lacked some daily necessities ( non-monetary poverty ) .
Approximately @percent@ of patients experience late reactivation of GO.
Approximately @percent@ of plans underreported rates of high-risk prescribing relative to calculated rates derived from Part D claims.
Approximately @percent@ of survivors and @percent@ of siblings reported ≥ @number@ fracture during their lifetime.
Approximately @percent@ of the articles suggested that older adults should explore new techniques to boost sexual pleasure , thereby medicalizing and ameliorating sexual decline.
Approximately @percent@ of the bereaved are at risk of bereavement-related mental health disorders.
Approximately @percent@ of the cohort was frail.
Approximately @percent@ of the dementia group and @percent@ of the non-dementia group were receiving at least one anticholinergic drug.
Approximately @percent@ of the non-buyers and @percent@ of the occasional buyers perceived organic meat as not or hardly likely to be available in their supermarket.
Approximately @percent@ of the participants were computer-users , and they had significantly lower levels of computer anxiety than non-users.
Approximately @percent@ of these cells exit the cell cycle permanently ; a significant increase in the doubling time of the cell population was observed.
Approximately @percent@ of these patients will suffer recurrence after surgery.
Approximately @percent@ of the smoking sample was former-smokers.
Approximately @percent@ of the study population experienced a transition annually.
Approximately @percent@ of the study population was over @number@ years old and mostly obese , potentially increasing risk for injury.
Approximately @percent@ of the U.S. cohort were from minority groups ; @percent@ of the total cohort.
Approximately @percent@ of women are affected.
Approximately @percent@ of XP patients in the United States have neurologic abnormalities including progressive sensorineural hearing loss ( SNHL ) .
Approximately @percent@ patients were APOEε4 positive in our study.
Approximately @percent@ ( @percent@ confidence interval , @number@.4%-25.0% ) of respondents were caregivers.
Approximately @percent@ to @percent@ of older adults experience unintentional weight loss and require intervention to maintain quality of life.
Approximately @percent@ were male , @percent@ had occupational risk factors , @percent@ had severe and @percent@ had very severe COPD.
Approximately @percent@ were unfamiliar with the ovulatory cycle.
Approximately-research activity is random , that does not change the cognitive response strategy under uncertainty environment.
Approximately two-thirds of anemia in American elderly is caused by chronic inflammation or is unexplained.
Approximate p-values indicated that reproducibility was better for FreeSurfer than for manual or FIRST , and that manual and FIRST did not differ.
Aprataxin exhibits homology to the histidine triad superfamily of nucleotide hydrolases and transferases and removes @number@'-adenylate groups from DNA that arise from aborted ligation reactions.
Apraxia favours AD.
Apraxia was most common in AD.
A pre- and post-test design was used to identify changes in participants ' perception of their nutritional and overall well-being.
A precise and delicate interplay exists among these processes to ensure normal hemostasis.
A precise control of lipid synthesis and distribution is crucial for cell function and survival.
A precision matrix obtained via the constrained ℓ1 minimization method is used to account for the within-subject correlation among multivariate outcomes.
A precore G1896A variant with high quasispecies diversity was recovered from the patient.
A pre-designed schedule was used to collect information on socioeconomic characteristics and type of activities performed by them.
A predetermined model with constants and coefficients optimized to various populations would enable interpretable and interesting comparisons between populations.
A predicted PV table , with a @percent@ confidence interval ( CIs ) , was developed after adjusting for these @number@ variables.
A prediction model including all traditional risk markers yielded a C-statistic of @number@ ( 95%CI @number@.52-0.66 ) .
A predictive equation was developed from @number@ subjects.
A predictive model has been used to estimate %PPP in VOO stored at different worldwide locations characterized with different temperatures.
A preliminary genetic association study indicated that rare NNT , TNIK , and PRKDC gene variants had nominally significant association with Alzheimer-type dementia risk.
A preliminary investigation using structural brain imaging revealed a region of anterior cingulate cortex that was thicker in SuperAgers compared with healthy 50- to 65-year-olds.
A preliminary session was conducted to assess their habitual number of chews ( HNC ) using pizza rolls as the test food.
A pre / posttest , quasiexperimental design assessed TTM constructs , Health-Related Quality of Life , and functional fitness measurements.
A pre-posttest quasi-experimental design without equivalent control group was used in this project.
A prescan diagnosis was made , diagnostic confidence was estimated , and drug treatment was provided.
A prevailing strategy is to search genome-wide for genes that evolved under positive selection based on the non-synonymous to synonymous substitution ratio.
A previous case-control study measured antibody responses to SGG pilus proteins Gallo2178 and Gallo2179 and identified significant associations with a small fraction of CRC cases.
A previous-day recall was performed.
A previously developed pharmacoepidemiological semi-Markov model was extended to apply for projection of future drug utilization.
A previous number was reused as a nogo stimulus and the other as a go stimulus , with new numbers serving as a baseline.
APRIL ( A proliferation-inducing ligand ) is a TNF family member that binds two TNF receptor family members , TACI and BCMA.
A primary culture was initiated with a pure population of HCECs in DMEM / F12 media containing @percent@ fetal bovine serum and other various supplements.
A primary intention of the scale was to eradicate sexual identity categories altogether in order to eliminate sexual identity-based persecutions and to promote equal rights.
A primary strategy proposed is to delay onset of AD.
A prime candidate responsible for damage and loss of function during aging is the accumulation of reactive oxygen species , derived from normal oxidative metabolism.
A principal component analysis ( PCA ) was performed to unveil independent factors that predict distinct aspects of tinnitus-related pathology.
A principal components analysis was performed to account for correlations in test scores.
A prior diagnosis of heart failure was the only variable associated with higher mortality in the three groups of subjects.
A priori approach defines dietary pattern based on existing knowledge.
A priori calculation of sample size gives a population of @number@ patients to be included in this multicenter trial.
A priori sub-group analyses were conducted to evaluate the effect of age at enrollment , dose level , and memory type tested.
A probabilistic sensitivity analysis ( PSA ) was performed to determine uncertainty around the incremental cost-effectiveness ratio ( ICER ) .
A probabilistic sensitivity analysis ( PSA ) was performed to quantify the level of uncertainty of the results found in the base case.
A probable case of CKDnT is defined as a suspect case with the same findings confirmed three or more months later.
A probit model was used to estimate the probability of care workers leaving their jobs in the next @number@ months.
A problem with early intervention is that it is very difficult to detect OA before irreversible damage has already occurred.
A procalcitonin level upon admission > @number@ ng / mL was an independent predictor of in-patient mortality.
A process evaluation will be conducted throughout the trial.
A professional art instructor provided a lesson and supervised practice in acrylic painting.
A progressive impairment in the functional reserve of multiple organs may affect either pharmacokinetics or pharmacodynamics during aging.
A progressive increase in the CD4 : CD8 ratio over time was observed without reaching a plateau.
A pro-inflammatory haplotype with a population frequency of @percent@ was associated with higher handgrip strength ( P = @number@ ) .
A proinflammatory milieu associated with central obesity is postulated to enhance muscle catabolism.
A prokaryotic member of the FAH superfamily , referred to as Cg1458 , was shown to encode a soluble oxaloacetate decarboxylase ( ODx ) .
A prolonged and widespread process of repair and reorganization of surviving neural circuits is instigated by injury to the adult brain.
A prolonged antibacterial activity of both films against Staphylococcus aureus ATCC @number@ was observed over a period of @number@ days.
A prolonged consolidation therapy period of ≥ @number@ or @number@ months had no positive effect on sustained viral suppression.
A prolonged positive energy balance impairs the ability of neurons to adapt to oxidative and metabolic stress.
A prominent and well-studied specialization is found in the mammalian auditory brainstem.
A prominent approach to study E2 effects in rodents is the inhibition of its synthesis by letrozole , which reduces LTPs and spine synapse density.
A prominent change is progressive left ventricular ( LV ) diastolic dysfunction , even though LV mass increases slightly during aging.
A prominent explanation for this pattern relates to deteriorating economic conditions , especially the sharp rise in unemployment associated with the Great Recession of 2007-2009.
A promising approach combines both activities within a dance training program.
A promising policy option for the Hong Kong government is to offer a tax incentive to promote additional savings for old-age income protection.
A promising psychological concept that could improve staff and care recipient outcomes is staff sense of competence in their capacity to provide dementia care.
A promising strategy for enhancing care and self-management of chronic illness is an integrative , whole-person approach that recognizes and values well-being.
A promising strategy in biogerontology is to slow down aging and to extend healthspan by hormetin-mediated hormesis.
A promising treatment being explored for tauopathies is passive immunization with anti-tau antibodies.
A prompt and evidence-based diagnostic and therapeutic approach is mandatory.
A pronounced increase in the accuracy of cortical parcellation and superior tensor alignment were observed when the customized template was used.
A propensity score-matched cohort of statin users and nonusers was created using @number@ variables.
A proper balance between synthesis , maturation and degradation of cellular proteins is crucial for cells to maintain physiological functions.
A proper genome-environment interaction is a pre-requisite for cognitive function.
A properly sized and functional heart is vital throughout the entire lifespan.
A proper secondary phenotype analysis , in this case , is complicated by the within families correlations on top of the biased sampling design.
A proposal to streamline future ADAMS assessments is offered.
A prospective \ "antiaging blood filtration column \ " ( AABFC ) is a nanotechnological device that would fulfill the central role in this approach.
A prospective case control study was performed in the nursing home of Local Health Care.
A prospective cohort study was conducted.
A prospective cohort study was conducted on @number@ CHC patients with SVR.
A prospective multicentre cohort study was performed in German haematology / oncology centres.
A prospective population-based study was conducted with a median of @number@ years of follow-up.
A prospective randomized clinical trial is required to validate the effect of atorvastatin.
A prospective study should be performed to validate this relationship.
A protein-protein interaction ( PPI ) network of DEGs was constructed with STRING and then visualized with Cytoscape.
A protein-protein interaction screen in the fly brain confirms that LRRK2 robustly interacts with numerous SV proteins , including synaptojanin-1 and EndophilinA.
A protein sample used as an internal control was labeled with NHS-Cy5 and run on each gel.
A protocol for this meta-analysis has been registered on PROSPERO ( CRD42016050934 ) .
A protocol of neuropsychological tests , global evaluation scales , functional scales , and depressive symptoms assessment was used.
A protocol of questionnaires was constructed for data collection , and included domains such as physical activity , quality of life , socio-psychological aspects.
A prototypical case is discussed in detail and unaddressed aspects of proprioceptive inattention are discussed through findings from four additional cases.
A provocative question for the field of cognitive aging is whether such changes in sleep physiology affect cognition ( e.g. , memory consolidation ) .
APS increased similarly after WP and LEAA.
AP sway variability was significantly greater in those with dementia as compared to those without dementia , irrespective of task condition.
A psychological component of the condition is evident and concurs at increasing the vulnerability of the individual to stressors.
A psychological threat affects gait and balance similarly to a physical threat among young participants but not among most older participants.
APTs are the only enzymes known to promote depalmitoylation.
APTX is found in the nuclei and mitochondria of eukaryotic cells.
A public database showed that ACSL3 level was higher in CRPC than in hormone-sensitive prostate cancer.
A PubMed and SCOPUS search until @date@ was performed , focusing on perspective studies reporting prognostic parameters in cancer data.
A PubMed search elicited @number@ English language articles published since @number@ additional articles were identified by reviewing reference sections and contacting authors.
A PubMed search was conducted resulting in twelve articles , based on ten studies.
A pulse wave is the displacement wave which arises because of ejection of blood from the heart and reflection at vascular bed and distal point.
A purpose-built longitudinal automatic method was used to segment WMH using constraints derived from an atlas-based model selection applied to a time-averaged image.
A purposive sample of executive directors of long-term care facilities in a large western state certified for Medicare / Medicaid reimbursement was used.
A purposive sample of @number@ disabled older persons was interviewed using a structured questionnaire.
A purposive sample of @number@ fathers ( age 50-80 ) completed measures assessing ego development , generativity , and costs and rewards of fatherhood.
A p value < 0.05 was considered significant.
A P value < 0.05 was considered statistically significant.
A p value less than @number@ was considered significant.
A P value less than @number@ was deemed statistically significant.
A P value lower than @number@ was considered to be statistically relevant.
A P value of < 0.05 was significant , and comparisons were two-tailed.
A PVR of @number@ ml or greater during the pressure-flow study was considered elevated for this study.
Aquaculture and substitutes of Hippocampus are valid approaches to protect Hippocampus form being endangered species.
A qualitative descriptive analysis was conducted to identify thematic content.
A qualitative descriptive design guided the primary study of @number@ community-living older adults , who participated in in-depth interviews.
A qualitative design was used with in-depth interviews conducted with @number@ Native Hawaiian kupuna and five Native Hawaiian health care providers.
A qualitative interview study was conducted following a Grounded Theory approach.
A qualitative interview study with family caregivers and an additional focus group was conducted.
A qualitative review of outcomes was performed.
A qualitative study employing in-depth interviews with @number@ older adults from two continuum-of-care facilities was conducted.
A qualitative study was undertaken to aid in the development of a tailored intervention for these patients.
A qualitative visual examination of acquired images demonstrated an age-dependent remodelling effect on collagen.
A quality assessment was conducted independently by two reviewers.
A quantitative calcaneal osteosonic index ( OSI ) was determined annually.
A quantitative polymerase chain reaction was used to measure relative telomere length ( RTL ) .
A quantitative proteomics approach was used to identify protein expression changes in AVMSMCs treated with miRNA mimics.
A quantitative study and a mixed-method study with quantitative outcomes showed that ICT-based interventions promote more social behaviours than non-technology-based interventions.
A quantitative understanding of influenza virus pathogenesis and its shift in the elderly is the key contribution of this work.
A quarter ( @percent@ ) of participants met criteria for impairment on the 3MS ; @percent@ met criteria for impairment on TMTB.
A quasi-experimental , cross-sectional , retrospective study is designed to identify and quantify the relationships present in processes and outcomes inherent in health care transitions.
Aquatic exercise appeared a better activity to improve dynamic balance.
Aqueous extracts of black and green tea ( Camellia sinensis ) were obtained by freeze-drying for this study.
Aqueous flare values were measured by laser flare cell meter.
Aqueous humor flows through Schlemm's canal ( SC ) , a lymphatic-like vessel encircling the cornea , and via intercellular spaces of ciliary muscle cells.
Aqueous humour exits the eye preferentially through the trabecular route at all ages.
A questionnaire about voting procedures and European elections was proposed in @number@ out of @number@ randomized facilities.
A questionnaire asked about the people's perception of their current mood and how they received support when they had problems.
A questionnaire ( Q ) to measure physical activity ( PA ) of persons ≥70 years for epidemiological research is lacking.
A questionnaire survey was undertaken by dermatologists to assess the severity of pore widening.
A questionnaire was applied to obtain socioeconomic and demographic date , factors related to the health and scales of the functional evaluation.
A questionnaire was designed to collect data on basic characteristics of children , breastfeeding , 24-hour dietary intake , and consumption and appetite of YYB.
A questionnaire was given to women attending a specialist menopause clinic ; @number@ women responded.
A questionnaire was sent to @number@ patients , and another similar questionnaire to their caregivers.
A questionnaire was used to assess relief or persistence of the symptoms before , during , and after tape adhesion.
A questionnaire was used to evaluate the easiness of accomplishment of spirometry and forced oscillation.
A questionnaire was used to interview elderly regarding dental health.
A questionnaire with closed response options was fielded to gain insight into attitudes toward broad prioritization criteria of patient groups.
A quota sampling design was used to ensure a broad spread of participants in terms of socio-economic position , age and gender.
ARA and DHA supplementation also increased coronary flow velocity reserve in elderly individuals ; this suggests beneficial effects of PUFAs on coronary microcirculation.
Arabic AMS scale was applied in the base line visit , then @number@ weeks after treatment.
Arachidonic acid and DHA containing PL species , ε4-status and Aβ42 / Aβ40 ratios provided @percent@ accuracy in detecting MCI / AD.
Arachidonic acid fails to reproduce these effects of DHA.
Arachidonic acid-induced aggregation was almost completely suppressed ( % maximum light transmittance aggregometry = 5 ± @percent@ ) .
A radioimmunoassay technique was used to measure 25OHD levels.
A raised HADS was more likely in females , socioeconomically deprived , multimorbid or younger ( 18-44 ) individuals.
A random-effect model was used and between-studies heterogeneity was estimated with I ( @number@ ) .
A random effect model was used to pool data.
A random-effect model was used to pool data.
A random effects meta-analysis found a medium to large ES for BT relative to comparison conditions.
A random effects model was used to calculate pooled relative risks ( RRs ) and @percent@ confidence intervals ( CIs ) .
A random-effects model was used to calculate the pooled relative risks ( RR ) with a @percent@ confidence interval ( CI ) .
A random effects model was used to present the effect estimate for the outcomes.
A random effect was included to correct for possible correlations between paired samples.
A random forest analysis was run to identify the best imaging predictor of global cognitive impairment and deficits of specific cognitive domains.
A randomised controlled crossover intervention study.
A randomized controlled clinical trial in KTRs that assesses the potential impact of phosphorus-lowering therapy on these hard outcomes may be warranted.
A randomized controlled trial over a 12-month period was carried out in @number@
A randomly assigned subsample additionally completed a 30-day daily diary.
A randomly chosen set of triplets occurred with high frequency , so there was no underlying rule to be learned.
A randomly chosen subset population of people at high risk of falling was then randomized into two arms , community-based and hospital-based fall assessments.
A random sample of @percent@ was drawn.
A random sample of resident charts was abstracted for fall risk reduction documentation ( n = 651 ) .
A random serum paracetamol concentration was measured at day @number@ in the treatment group.
A range of acceptable positions would be more helpful and realistic to a surgeon trying to ensure adequate prosthesis positions.
A range of birth cohorts coexist in time , place , and social relationship.
A range of data generation activities were used to examine what worked well.
A range of imaging , neuropsychological , cerebrospinal fluid , and pathological findings are reported that extend the known phenotype.
A range of neuroimaging databasing approaches has streamlined the transmission , storage , and dissemination of data from such brain imaging studies.
A range of sexually transmitted infections ( STIs ) such as chlamydia , gonorrhea , syphilis , and HIV have been reported among older adults.
A range of sociodemographic and biomedical factors were associated with being persistently active in older adults.
A rapid growth change followed by a continuous slower change in quantitative MR parameters can be modeled with a logarithmic or exponential decay function.
A rapid increase in incidence of neurodegenerative disorders has been observed with the aging of the population.
A rapidly aging correctional population has led to an increasing number of patients with serious progressive and terminal illnesses in correctional settings.
A rapidly declining eGFR prior to entering the LCC was predictive of RRT requirement.
A rapidly increasing number of case reports are being published describing ICS induced by the interaction of ritonavir and injected corticosteroids , namely triamcinolone acetonide.
A rapidly increasing number of medical imaging studies is longitudinal , i.e. involves series of repeated examinations of the same individuals.
A rare heterozygous TREM2 variant p.R47H ( rs75932628 ) has been associated with an increased risk for Alzheimer's disease ( AD ) .
A rare tau variant p.A152T was reported as a risk factor for frontotemporal dementia spectrum and Alzheimer's disease in an initial case-control study.
ARA supplementation decreased P300 latency and increased P300 amplitude of event-related potentials in healthy elderly men.
A rat ICH model in the caudate putamen was established and subjected to behavioral tests.
A ratio of hippocampal and temporoparietal volumes provided excellent discrimination of atypical AD from FTLD subjects.
ARC diagnoses during 2004-2012 were analyzed using latent class modeling adjusted for confounders.
Architecturally the implemented IAServ leverages web services and cloud computing to provide economic , scalable , and robust healthcare services over the Internet.
Archival and survey-based data were obtained on neighborhoods , where the men lived and where they socialized most often.
Archival issues can be accessed via the website : @url@ at which European health professionals can register online to receive copies of the quarterly publication.
Arch Ophthalmol.
Arcsinh transformation of the data were considered , as this improved the normality of the parameter distributions.
ARC was recorded by LOCSⅢ classification system.
A reading of the current research landscape and literature , summarised in this paper , strongly suggests it is the former.
Are age differences in interference control more myth than reality ?
Areal and volumetric bone parameters were determined using dual-energy x-ray absorptiometry ( DXA ) and peripheral quantitative computed tomography ( pQCT ) .
Areal BMD measurements were performed using dual-energy X-ray absorptiometry , and arterial stiffness was measured using the brachial-ankle pulse wave velocity ( baPWV ) .
Areal BMD was assessed by dual energy x-ray absorptiometry at baseline and @number@ months.
Areal BMD was lower in IGHD , but vBMD was similar in the two groups.
Areal BMD was measured , and vBMD was calculated at the lumbar spine and total hip.
Areal bone mineral density ( aBMD ) measured by dual-energy X-ray absorptiometry ( DXA ) identifies @percent@ of men who will sustain fragility fractures.
A real data example is presented to illustrate the methods.
A real-time computerised device was used on a force plate for movement analysis.
A Real Time Quantitative PCR was performed in order to verify leukocytes telomere length.
Area measurements and cellularity were quantified using the image analysis software Stereo Investigator , employing planimetry and counting frames , respectively.
ARE , antioxidant responsive element ; Nrf2 ( NFE2L2 , Nuclear factor ( erythroid-derived @number@ ) -like @number@ ) .
AREAS COVERED : An unrestricted PubMed literature search on antidepressant pharmacokinetics and sex was performed.
Areas covered : Atazanavir sulfate + cobicistat ( ATV / c ) was recently approved for the treatment of HIV-1 infection.
AREAS COVERED : Available evidence about safety , tolerability and potential adverse events relative to GLP-1Rx agonists presently used.
AREAS COVERED : In this review , the authors highlight and critically review the possible mechanisms of the aging process and related illnesses.
Areas covered : In this review , we summarize the ongoing research related to pancreatic PAX genes in diabetes mellitus and pancreatic neuroendocrine tumors.
AREAS COVERED : OAB medications , with a focus on tolterodine for the treatment of UUI are reviewed.
Areas covered : Over the years , several concepts have been put forward for the development of a viable anti-aging regimen.
AREAS COVERED : Recent literature investigating the efficacy and indications of live attenuated zoster vaccine.
Areas covered : The antivirals for CHC have evolved from interferon ( IFN ) -based therapyto interferon-free DAAs.
AREAS COVERED : The authors describe the developments in analyzing Sirtuin activity and conceptual advances in the identification , improvement and design of Sirtuin-modulating compounds.
AREAS COVERED : The authors summarise recent knowledge about MP biology and pathophysiology.
AREAS COVERED : The major drug classes recently developed and / or in current development for migraine treatment are discussed.
Areas covered : The pathophysiology of decreased bone mineral density in patients with diabetes is discussed.
Areas covered : This article summarizes the recommendations from existing clinical guidelines and recent reviews on the treatment of LLD.
Areas covered : This narrative review discusses use of monoamine oxidase inhibitors in the context with chronic neurodegeneration.
AREAS COVERED : This review discusses possible strategies for dermal delivery of the antioxidant vitamins E and C , as oral supplementation has proved insufficient.
AREAS COVERED : This review focuses on iron chelators used as therapeutic agents.
AREAS COVERED : This review focuses on novel approaches to target conformational diseases.
Areas covered : This study collects patent data from the Integrity database.
Areas covered : Underlying mechanisms that define atrophic AMD will help provide novel therapeutic targets that will address this largely unmet clinical need.
AREAS COVERED : We reviewed data regarding the use of T as a salvage therapy in PDE5i nonresponders.
Areas covered : We reviewed the current understanding of UAB with special focus on pharmacological treatments and potential pharmacotherapy options particularly in neurological conditions.
Areas covered : When glycemic levels are not adequately controlled , an association of GLP-1 receptor agonists and insulin therapy can be adopted.
Areas covered will include preparation , harvesting , processing , and injection techniques.
AREAS COVERED : β-amyloid ( Aβ ) deposits activate the complement system , which , in turn , stimulates microglia to release neurotoxic materials.
Areas discussed included features that would be wanted or unwanted , form factor and context of use.
Areas for future policy work are also identified in order to make legislation more inclusive and effective.
Areas for program improvement include greater attention to peer counseling and timely communication with participants ' healthcare providers.
Areas of 2mm thick pure enamel and 3mm enamel-dentine complex were detected and their L a b and CR evaluated.
Areas of similarity and difference between human and mouse models are highlighted.
A reason contributing to this may be the additional modulation by obesity.
Areas under the ROC curves were used to estimate overall predictive accuracies.
Area under curve ( AUC ) was evaluated for both Fried's and IFi frailty index.
Area under receiver operating characteristic curves of GC-IPL were generally higher than that of RNFL to discriminate AD and MCI from the controls.
Area under the receiver operating characteristic curve ( AUC ) , sensitivity ( sens ) and specificity ( spec ) .
Area under the receiver operating curve for patients ≥70 it was @number@
A receiver operating characteristic curve analysis and a logistic regression analysis were used to examine the predictive accuracy of the ABC-H scale.
A receiver operating characteristic ( ROC ) analysis was performed.
A receiver operating characteristic ( ROC ) curve was calculated from sensitivity and 1-specificity values for diagnoses of dementia versus no dementia.
A receiver operator curve demonstrated high sensitivity-specificity for use of erythrocyte lifespan to detect device thrombosis ( AUC = @number@ ) .
A recent aging study showed that cortisol levels during fMRI have an age-dependent effect on cognitive performance and brain functioning.
A recent editorial entitled \ "State of Aggregation \ " ( Nat.
A recent epidemiologic study shows that serum phosphorus decreases over time not only in pediatric age but also during adulthood.
A recent genome-wide association study has identified an association between leukocyte telomere length ( LTL ) and a locus at 3q26 that includes TERC.
A recent hypothesis derived from the observation of hypovigilance in manic patients postulates that modafinil may also have a beneficial effect in reducing manic behaviors.
A recent hypothesis suggests exploring the role of dopamine to study this interaction.
A recent large clinical trial demonstrates an association of omega-3 fatty acids blood levels with increased incidence of prostate cancer , especially aggressive prostate cancer.
A recently developed compound , C-xylopyranoside derivative ( C-Xyloside ) , was designed to mimic β-xylosides , which are known initiators of glycosaminoglycan biosynthesis.
A recent meta-analysis of genome-wide association studies in Parkinson's disease ( PD ) has identified the rs12456492 variant in RIT2 as a new susceptibility loci.
A recent National Institute on Aging Research Summit led to a number of requests for applications.
A recent paper by Deelen et al.
A recent phase III clinical trial of an sPLA2 inhibitor ( varespladib ) was stopped prematurely for lack of efficacy.
A recent positron emission tomography imaging study demonstrated upregulated brain arachidonic acid ( AA ) metabolism in AD patients.
A recent publication by Algarabel et al.
A recent randomized controlled trial of a multifaceted podiatric medical intervention demonstrated a @percent@ reduction in the fall rate over @number@ months.
A recent study demonstrated reduced days with pain and improved physical activity quality of life following high-dose vitamin D therapy.
A recent study has demonstrated that in blood cells of aging subjects , p53 may induce early pathological changes that precede the amyloidogenic cascade.
A recent study in autopsy-confirmed Parkinson's disease ( PD ) patients and controls revived the debate about the role of PARK10 in this disorder.
A recent study showed that 25-dihydroxyvitamin D rather than @number@ , 25-dihydroxyvitamin D could directly suppress hepatitis C virus assembly.
A recent study suggests that cyclin-dependent kinase @number@ ( CDK5 ) is responsible for the phosphorylation of SIRT1 at the serine @number@ residue.
A recent Swedish random population sample with high-quality spirometric measurements enabled the present analyses.
A recent trend shows the aging of the inpatient TBI rehabilitation population.
Are cofilin rods / aggregates found in the same neurites as hyperphosphorylated tau ?
A recognised classification system should be used to identify and document skin tears and guide treatment decisions in line with local wound management protocols.
A recurrent and increasingly important theme is resilience - the capacity to maintain or regain well-being in the face of adversity.
A redacted Canadian data set on resident-to-resident abuse is also reported on.
A reduced level of DHA is associated with cognitive decline during ageing.
A reduced model omitted antiretroviral therapies.
A reduction in attentional control skills is proposed to account for the divided attention deficit reported in aging.
A reduction in average IGA score was also significant ( P < @number@ ) .
A reduction in depression was seen in carers when the patients received domiciliary nursing care.
A reduction in executive function ( EF ) performance is a major factor associated with the loss of functional independence among older adults.
A reduction in muscle mass increases the risk of functional limitations among older individuals.
A reduction in nitrate administration compared with baseline was also seen in the TM group.
A reduction in or delay of the frailty state can improve the quality of life of the elderly.
A reduction in pigment was observed with both lasers during the study period.
A reduction in the acetylation of isocitrate dehydrogenase @number@ was observed following ET that may counteract the effect of acute oxidative stress.
A reduction in the efficacy of this system might compromise cell viability and dentinogenic secretory capacity.
A reduction in the levels of acetylated forms of H3 and H4 histones and p53 protein was also found.
A reduction in the number of smooth muscle cells ( SMCs ) has been demonstrated in relation to this change in oxygen tension.
A reduction in the relaxation rate can be seen as an indication of thinning cylinders , corresponding to reduced bone stability and ultimately , osteoporosis.
A reduction of ≥25% in the ASMR occurred in @number@ countries , while a corresponding increase was observed in @number@ countries.
A reduction of endogenous mechanisms against ischemic insults has been proposed to explain this phenomenon.
A reduction of pain independent of the number of fractures , significantly reduced torques , and reduced muscle strength were registered.
A reduction of the connectivity between brain areas was demonstrated by combining neuroimaging technologies and graph theory.
A reference librarian trained in systematic reviews conducted the final search.
A reflective spectrophotometer was used to evaluate color changes.
A regional brain activity measurement was constructed based on the variation of the RS-fMRI signal of these NC.
A regional variability in the aging patterns across the limbic system was present.
A region of interest analysis restricted to behavioral variant frontotemporal dementia and semantic variant primary progressive aphasia patients alone confirmed this result.
A registered occupational therapist delivered the intervention in two sessions held approximately @number@ month apart.
A regression analysis indicated that attitudes , knowledge , and previous formal contact were significant predictors of interest.
A regular physical activity should be performed with low to moderate intensity exercise.
A rehabilitation program provided in a short-term residential care setting may help to fill the service gap.
A relationship between blood pressure level and cardiovascular morbidity and mortality can be demonstrated by way of a J-curve.
A relationship between Stroop performance and DMN ( but not SAL ) functional connectivity was stronger in CSF Aβ₄₂-positive individuals.
A relationship between the presence of a primitive reflex and nutritional status was shown.
A relationship is also found between perfusion and MBCV for all physiological states ( R ( @number@ ) = @number@ ) .
A relationship was found between the adaptive strategies that participants developed as they moved through life phases and the impairment stages.
A relative sparing of Time-based PM was observed in SD , in contrast with global PM deficits in bvFTD.
A relevant part of literature has highlighted the influence of discrimination based on race or ethnicity on mental and physical health outcomes.
A reliable and reproducible neurochemical profile of the human hippocampus was obtained using MRS at @number@ T in a small hippocampal volume.
A reliable biomarker for the prediction of this complication is lacking.
A reliable mouse model of early life adversity leading to lasting behavioral changes would facilitate progress in elucidating the molecular mechanisms underlying these adverse effects.
A reliable , well-characterized source of retinal cells will be needed for replacement purposes.
A remarkable interindividual variability was found and several patients disclosed incongruity between the trajectory of white matter alterations and biochemical control.
A reminiscence bump was also noted for success , although this was later in the lifespan than other reminiscence bumps.
A repeat echocardiography showed a normalized estimated ejection fraction in both patients.
A repeated measures observational study was conducted in two VA facilities with @number@ long-stay residents.
A replication study of obesity was conducted using the Health Aging and Body Composition ( Health ABC ) sample.
A representative sample of @number@ male and @number@ female , totally @number@ participants aged above @number@ years old was examined.
A representative sample of @number@ @number@ and @number@ participants born 1920-1921 were assessed at home at ages @number@ @number@ and @number@ respectively.
A representative sub-sample of @number@ men within the Caerphilly Cohort kept a weighed dietary record for seven days.
A representative subset of these alterations have been confirmed in an independent cohort.
A reproducible , accurate , and automated breast density measurement is required for full-field digital mammography ( FFDM ) to support clinical applications.
A Research Steering Committee has been established , two meetings of study leaders held , and a website developed.
A resilient carer was characterised as someone who stays positive and actively maintained their relationship and loved one's former self.
A responsive evaluation methodology was followed to foster reflexive learning in and among stakeholders as the basis for programme contextualization.
Are structural changes relevant to the patient ?
A RESULTS : EGJ-CI at rest was similar for older subjects compared to controls.
A retest of the odor memory test ( Sniffin ' TOM = test of odor memory ) took place @number@ days later.
Are the dose , frequency and formulation appropriate ?
Are the effects / benefits of the MT4C intervention achieved at no additional cost compared to an educational control group ?
Are there advantages to being tall and disadvantages to being short ?
Are there alternatives - with greater efficacy , effectiveness or tolerability - that might be considered ?
Are there evidence based solutions to the state rural primary care workforce crisis ?
Are there factors that accelerate the decline or slow it ?
Are these changes attributable to declining disability rates , or has LTC use given disability changed ?
Are they so different compared to teenagers ?
Are they truly associated , or is insulin resistance just related to aging , obesity , or to the presence of metabolic syndrome ?
Are they useful in fostering personal growth and individual integration of the elderly , by promoting satisfaction , opportunities for action , and self-expression ?
Are three well-known reference equations clinically useful in the Swedish adult population ?
A retrospective analysis of gait and clinical data was conducted using data pooled from five prior studies.
A retrospective analysis of IVF results was conducted in @number@ patients aged @number@ to @number@ years.
A retrospective analysis was performed of @number@ patients with papillary and follicular thyroid carcinoma.
A retrospective chart analysis revealed that the most commonly reported problems were circulation and nutrition.
A retrospective clinical study was carried out.
A retrospective cohort study was performed in suppressed adult HIV + patients.
A retrospective comparison of wrinkle widths in @number@ climacteric women with climacteric symptoms with or without PPE treatment was also performed.
A retrospective , consecutive case-series analysis was organized and performed during the 20-year study period in Huashan Hospital , Shanghai , China.
A retrospective cross-sectional audit of HMR reports pertaining to @number@ community-dwelling older people ( > or = 65 years ) was conducted.
A retrospective descriptive analysis of alert management , performed PoCT and medication dispensing histories was performed.
A retrospective mono-center cohort study was performed.
A retrospective observational study was conducted involving patients undergoing endoscopy for dyspepsia from @number@ to @number@
A retrospective review of @number@ patients undergoing combined treatment is performed.
A retrospective screen was made for patients undergoing conventional PNL surgery for renal stones performed in two separate centers between @number@ and @number@
A retrospective study found that this score was also associated with mortality in COPD exacerbations.
A review of general aviation safety ( 1984-2017 ) .
A review of prior research indicates contradictory aging patterns in GC regulation across and even within species.
A review of state regulations found that @number@ states restrict nonnurses to assisting with self-administration of medications.
A review of the literature suggests that OA is inversely related to OP in general when studied cross-sectionally and systematically.
A review of the literature was conducted in order to explore the socio-environmental factors that may influence the cognitive vitality of seniors.
A review of the literature was executed using the MEDLINE database and clinical trials from @number@ to @number@ were selected for analysis.
A review of the literature yields mixed findings but suggests that inflammatory dysregulation is evident and may be related to clinical outcomes.
A review was made of the cases reported in adults in the medical literature ( Medline ) up to @date@ .
A review was performed for publications on gender differences in facial anatomy , behavior , and the use of minimally invasive aesthetic procedures in men.
A revised version was tested for inter-rater reliability in study @number@
A revived dedication to the physical examination may enhance our ability to correctly diagnose various pathologies about the elbow.
AR expression is associated with a less aggressive phenotype and a good prognosis in patients with ER-positive breast cancer.
AR expression levels were analyzed in @number@ invasive breast cancers by immunohistochemistry and any association with the clinicopathological features was evaluated.
AR expression was associated with ER level , and it increased with age in ER-positive cases.
AR expression was higher in estrogen receptor ( ER ) -positive cases than in ER-negative cases ( P < @number@ ) .
ARF6 was necessary for nephrin activation-induced ruffling and focal adhesion turnover , possibly by altering Rac1 activity.
ARFI is a non-invasive technique that is feasible to perform in children with both the @number@ C1 and @number@ L4 probes.
Arf / p53 pathway protects the cells against DNA damage induced by acute stress.
Argentina has reached an advanced stage of demographic transition and presents a comparatively high rate of cancer mortality within Latin America.
Arginase constrains endothelial nitric oxide synthase activity by competing for the common substrate , L -Arginine.
Arginine deficiency in sepsis may impair nitric oxide ( NO ) production for local perfusion and add to the catabolic state.
Arginine vasopressin ( AVP ) levels were found to be higher in the elderly than in young subjects.
Argonaute @number@ expression is critical for stem cells to escape senescence by downregulating miR10b and miR23b.
Argyrophilic grains are immunopositive for 4R-tau.
Argyrophilic grains were detected in four patients.
Argyrophilic grains were observed in all CBD cases ( @percent@ ) despite a lower average age at death in this population.
Arhalofenate , an emerging uricosuric anti-inflammatory drug , prevents gout flares while reducing serum urate.
ARHI is an important frailty marker , and several factors related to physical frailty could be associated with cognitive impairment.
ARHL is caused by the interaction of multiple factors , including cochlear aging , environment , genetic predisposition , and health comorbidities.
ARIA- disseminated and implemented in over @number@ countries globally- is now focusing on the implementation of emerging technologies for individualized and predictive medicine.
A rich literature documents the decline of olfactory acuity in aged humans , but the underlying cellular and molecular mechanisms are largely unknown.
A rise in the prevalence of incontinence among older women increases the risk of vulvar and perineal dermatitis.
A risk analysis was performed in successive cohorts from 1910-1919 to 1960-1969 , comparing mortality slopes.
A risk-prediction model using information easily obtained on admission could help to identify high-risk individuals.
A risk typology consisting of four time-invariant groups was detected based on the components of MetS for all subjects.
ARM antibodies would be conjugated irreversibly to ARMs on contact surfaces of the reaction platforms inside the AABFC till near-youth homeostasis is attained.
Arm-leg and inter-arm coordination improved with increasing gait speed in both groups , but older adults had weaker inter-leg coupling following perturbation at all speeds.
Armodafinil was generally well tolerated by both groups.
Arm pulse propagation time , pulse wave velocity ( PWV ) and arterial volume distensibility were determined.
ARMS2 / HTRA1 risk alleles decrease SOD2 defense , making RPE more susceptible to oxidative damage and thereby contributing to AMD pathogenesis.
Arm swing amplitude decreased with age under all conditions ( p = @number@ ) .
ARM was graded from standardized fundus photographs according to the International Classification System.
A robust brain-cognition change-change association was observed for episodic-memory decline and atrophy in the hippocampus.
A robust HRQoL questionnaire involving seven domains was used to collect data from the study participants.
Aroeira and cardol attained intermediate outcomes whereas PACs provided the lower resistance.
A role for innate and adaptive immune system in adult neurogenesis has been also reported during aging.
A role of leptin in reward learning is not supported by this study.
Aromatase inhibitors are widely used in breast cancer and other endocrine conditions.
Around a half of multiple sclerosis ( MS ) patients suffer from cognitive impairment such as attention deficit.
Around half felt that the menopause had resulted in skin changes ; dry skin was the predominant complaint at this stage.
Around half of all care home managers reported they had experienced behaviours they found difficult.
Around @number@ respondents provided a diary about the prior day and rated how tired they felt during selected activities.
Around one in ten residents of the UK are foreign born , a lower proportion than many developed countries.
Around @percent@ of the participants reported at least a mild form of ED.
Around the acini , the myofibroblasts were found.
Around the world , there is an increasing need for more efficiency in healthcare alongside cost containment.
Arousal onsets preceded PLMS onset in @percent@ of pairs , while the opposite was true for the remaining @percent@ of pairs.
Arousals are often considered to be events which have an abrupt onset and offset , indicating abrupt changes in the state of the cortex.
Arousal worsened both groups ' between-item memory binding.
Arousing events are better remembered than mundane events.
A routine screening program is feasible within the public healthcare system of Costa Rica.
AR patients had more sneezing and nasal pruritus , whereas NAR was characterized mainly by nasal obstruction and rhinorrhea.
AR-positive cells were measured by flow cytometry.
Array assays revealed that the inflammatory cytokine interleukin-6 ( IL6 ) is a prominent AR target gene in ESCC.
Arrays allowing hypothesis-free searches on a scale resembling genome-wide studies of SNPs have become available only very recently.
Arrest is due to an inability to produce a functional extracellular matrix ( ECM ) , because growth on normal ECM rescues proliferation.
Arrestive tissue engineering tries to stop aberrant growth which , if left uncontrolled , would result in a decrease in function.
Arrhythmia circuits have been characterized , and the impact of pulmonary valve replacement on sudden death has been further questioned.
Arsenic exposure had no effect on pregnant dam weights or water consumption , litter size , offspring birthweight or weight at weaning compared to control.
Arsenic exposure may contribute to disease risk in humans through alterations in the epigenome.
Arsenic exposure significantly decreased serum amylase in female.
Arsenic is an environmental toxicant , free-radical generator , carcinogenic agent , and aging promoter.
Arsenic levels were @number@ @number@ and @number@.7μg / L at the 50th , 75th , and 90th percentiles , respectively.
Arsenic trioxide ( ATO ) as an anti-tumor drug could induce differentiation and apoptosis in tumor cells.
AR silencing by siRNA transfection resulted in inhibition of proliferation of T24GR cells.
ART arrested the cell cycle in the G2 / M phase , which was accompanied by an upregulation of p21.
Artefacts were reduced by filtering connected components in the initial masks based on their standardised T2 w intensity variance.
Arterial ageing is no longer considered an inexorable process.
Arterial aging is a major risk factor for the occurrence of cardiovascular diseases.
Arterial blood gases , respiratory rate and dyspnoea improved significantly faster with NIV than with SMT.
Arterial calcifications were assessed by US of carotids , femoral and tibial arteries , and labeled positive if calcification was found in any arterial site.
Arterial changes in young hypertensive patients mimic those in old normotensive individuals.
Arterial elasticity was determined using radial artery pulse wave analysis.
Arterial endothelial dysfunction is an early event in the pathogenesis of atherosclerosis and predisposes individuals to the deposition of unstable atherosclerotic plaques.
Arterial health may influence muscle function in older adults.
Arterial hypertension and a higher BMI were significantly associated with an increased age-adjusted WLR.
Arterial hypertension contributes essentially into development of chronic heart failure and chronic ischemia of the brain , which results in social dependence of geriatric patients.
Arterial responses to diverse pathologies and insults likely occur via similar mechanisms.
Arterial segments of aged patient with severe atherosclerosis showed a glycosaminoglycan composition similar to aneurysms samples.
Arterial spin labeling ( ASL ) is an fMRI method that provides absolute measurement of CBF non-invasively and with higher spatial resolution than non-MRI methods.
Arterial spin-labeling parenchymal CBF values were averaged over the whole brain to quantify the mean pCBF ( ASL ) value.
Arterial stiffness appears to be an independent contributor to hypertension , even after adjusting for age and other covariables.
Arterial stiffness chronicles the cumulative burden of cardiovascular disease risk factors.
Arterial stiffness derived using CAVI in healthy subjects increases linearly with aging , and is higher in men than in women.
Arterial stiffness directly relates the detrimental effects of hypertension on peripheral organs with dire consequences for the extensive microvasculature structure of the kidneys and brain.
Arterial stiffness has been accumulating evidence as an intermediate cardiovascular endpoint.
Arterial stiffness has been proposed as an indicator of vascular aging.
Arterial stiffness increases with age and in coronary artery disease.
Arterial stiffness in turn is associated with smaller retinal artery width.
Arterial stiffness is an established marker of cardiovascular morbidity and mortality and a potential therapeutic target.
Arterial stiffness is an independent predictive parameter of overall and cardiovascular mortality in these patients.
Arterial stiffness is a predictor of cardiovascular mortality.
Arterial stiffness is a risk factor for cardiovascular and chronic kidney disease.
Arterial stiffness may be a cause of cerebral small vessel disease and cognitive impairment.
Arterial stiffness parameters and pulse wave velocity ( PWV ) were evaluated in @number@ obese adolescents and @number@ healthy controls.
Arterial stiffness was measured as cfPWV by noninvasive tonometry.
Arterial stiffness was measured by arterial tonometry.
Arterial stiffness was measured using pulse wave velocity.
Arterial transmural pressures on the whole right arm were reduced with a @number@ cm long cuff inflated to @number@ @number@ @number@ and @number@ mmHg.
Arterial walls stiffen with age.
Arterial wave reflection was identified by measurements of blood flow waveforms before and after arterial branching.
Arteries and the heart change with aging while interacting with each other.
Arteries were tested using planar biaxial extension , and their behavior was modeled with a constitutive relation that included stiffening functions of age.
Arteries with atherosclerotic occlusive disease demonstrate decreased ICA tortuosity and smaller bifurcation angles compared with nondiseased carotid arteries.
Arteries with DM stiffened significantly faster in the circumferential direction than arteries without DM.
Arteriolosclerosis and diffuse white matter changes are the hallmark features of both sporadic and hereditary SVDs.
Arteriolosclerosis appears specific to hippocampal sclerosis of ageing brains , because brains with Alzheimer's disease pathology did not show the same morphological alterations.
Arteriolosclerosis is a subtype of cerebrovascular pathology characterized by concentrically thickened arterioles.
Arteriolosclerosis showed a positive correlation with lacunar infarcts ( OR , @number@ @percent@ CI , @number@.0-4.2 ) but not Alzheimer disease pathology.
Arterio-venous ratio ( AVR ) and microvascular abnormalities were attained by quantitative and qualitative assessment of fundus photographs.
Artesunate ( ART ) has high prophylactic efficacy against Schistosoma japonicum infections and has been used to treat and prevent schistosomiasis in China since @number@
ART for balance loss in the forward direction due to tripping was on average.
Arthralgia was reported @number@ times with Synvisc-One , @number@ with Hydros , and @number@ with Hydros-TA.
Arthritic disease is one of the most common age-related pathologies worldwide.
Arthritis and joint disease are common and contribute to disability and pain.
Arthritis and vitamin D insufficiency increased the risk of ADL disability in this population.
Arthritis is strongly associated with pain at the end of life.
Arthrodesis continues as a treatment for digital osteoarthritis , but the surgeon must balance the risks of complications with the benefits of improved patient outcomes.
Arthroplasty was performed in @number@ patients and internal fixation in @number@ patients with non-displaced intra-capsular PFFs.
Article registered in the Australian New Zealand Clinical Trials Registry ( ANZCTR ) under the number ACTRN @number@
Articles cited herein were identified via a search of PubMed from @date@ to @date@ .
Articles found were screened first by title and abstract and then by five criteria.
Articles meeting inclusion criteria were then critically appraised to exclude poor quality studies.
Articles must have gathered information on program design , goals , outcomes , or participants ' perceptions.
Articles of any methodology were considered.
Articles of this type that were considered to be of good quality were included in the meta-analysis.
Articles published from @number@ through @date@ were located from MEDLINE and EMBASE databases , @number@ articles were finally included in the review.
Articles published in English ( 1986-2016 ) were included.
Articles were acquired from a systematic search of major databases from inception till 01 / 2016.
Articles were further excluded if not conducted with humans or only secondary analyses were reported.
Articles were limited to those relating to photoaging.
Articles were selected on the basis of the study design and importance , in the light of authors ' clinical experience and personal judgment.
Articles were then determined to be relevant or irrelevant based on their abstracts.
Articles which are searchable on MEDLINE / PubMed and from the main national / international congresses in the field of HIV therapy are reviewed.
Articular cartilage chondrocytes survive and maintain tissue integrity in an avascular , low-oxygen environment.
Articular cartilage is a unique biphasic material that supports a lifetime of compressive and shear forces across joints.
Articular cartilage vesicles promote crystal formation , and these vesicles are found near the periphery of chondrocytes.
Articular evaluation is part of physiotherapeutic assessment and helps in establishing a precise diagnosis and deciding appropriate therapy.
Artificial aging did not influence failure load of the tested restorations.
Artificial aging of RPE lipofuscin gives a complex mixture of structurally related components.
Artificial APP ubiquitination with rapalog-mediated proximity inducers reduced Aβ40 generation.
Artificial beads , MI or GV oocytes , and empty zona can be used as a container for intrauterine replacement of implantation-promoting compounds.
Artificial blood substitutes or in vitro stem cell-derived blood components might also become alternatives in the future.
Artificial intelligence ( IA ) is the subject of much research , but also many fantasies.
ART is a significant and safe procedure for anti-aging in male.
Artistic ability and creativity are defining characteristics of human behavior.
AR transcriptional activity was found to be reduced in T24GR cells by enzalutamide treatment.
ART upregulated the expression of Beclin1 , an initiator of autophagy ( type II programmed cell death ) .
ART use and disease characteristics were collected longitudinally.
A rural region ( @number@ counties ) received the intervention , consisting of focus groups , Extension Agent training , and television-based social marketing campaign.
AR was also detected in exosomes isolated from LNCaP cells by anti-PSMA and anti-CD9 beads , showing that AR is present in prostate cancer-related exosomes.
Aryl hydrocarbon receptors ( AHRs ) are chemical sensors that are abundantly expressed in epidermal keratinocytes and mediate the production of reactive oxygen species.
AS101 treatment markedly reduced the pro-inflammatory cytokine levels , while increasing anti-inflammatory cytokine levels.
AS101 treatment reduced the infiltration of CD4 ( + ) and CD49 ( + ) / VLA4 T cells.
As a bioactive molecule , allicin has antioxidant , anti-inflammatory , and lipid-regulating mechanisms.
As a candidate approach , the author also highlights the potential of targeting individual FOXO signaling pathways to combat senescence and stimulate tissue rejuventaion.
As a causal antibiotic treatment is possible this infectious disease should be considered seriously in gerontopsychiatric patients.
As acceptable psychometric properties are a prerequisite for that , we are currently carrying out a study with that focus.
As a cell ages , damaged organelles and abnormal proteins accumulate.
ASA classification is the best predictive value for overall mortality.
As a concept and condition , frailty is poorly understood and underrecognized in clinical settings.
As a concept in gerontology , gender appears as lists of traits learned through socialization when theorized at all.
As a consequence , a growing number of these patients develop age-related co-morbidities , such as cardiovascular disease and cancer.
As a consequence , conventional interpretations of the observed rates of adult mortality decline in societies that experience Barker frailty may be inappropriate.
As a consequence , disease incidence increases with age.
As a consequence , EP impaired cell motility , cell proliferation , and anchorage-independent growth of MM cells.
As a consequence , fewer people from this ethnic group receive a diagnosis of dementia.
As a consequence , genuine information about preferences for health insurance is not available.
As a consequence , GI morbidity in the elderly represents an increasingly relevant burden for public health systems.
As a consequence , infectious diseases are more frequent and severe in elderly persons and immunological protection following vaccination is reduced.
As a consequence , in many situations , they need assistance that is not granted in time.
As a consequence , loss of function of the EZH2 / MUS81 axis promotes PARPi resistance in BRCA2-deficient cells.
As a consequence , mutant β-cells showed less on-cell KATP channel activity and fired action potentials in glucose-free solution.
As a consequence of aging , elderly people exhibit alterations in the sleep architecture and sleep-wake rhythm.
As a consequence of changes in arterial wall that leads to arterial stiffness , the majority of elderly patients suffer isolated systolic hypertension.
As a consequence of immunosenescence , older people have a higher risk to develop infections as well as cancer.
As a consequence of these exacerbations in cardiovascular risk factors , already half of the world's cardiovascular burden occurs in the Asia-Pacific.
As a consequence of this extended longevity they are vulnerable to the same age-associated health problems as elderly adults in the general population without ID.
As a consequence , older patients have worse outcomes than younger patients.
As a consequence , pathological changes resulting in vascular injury ( e. g. atherosclerosis , age-related macular degeneration ) may be evolved.
As a consequence , rising longevity-through falling mortality rates-may even reduce HCE.
As a consequence , the markers currently utilized to detect senescent cells are limited and lack specificity.
As a consequence , the question of the PPI-clopidogrel interaction is still unresolved , and clinical consequences cannot be excluded.
As a consequence , there has been a dramatic increase in the number of PLWH who are diagnosed with cancer.
As a consequence there is a need to investigate the aging and anti-aging processes of golden hamster oocytes.
As a consequence , the root-mean-square of the 3rd and 4th order aberrations in elderly people has a higher value.
As a consequence , the shape complexity of the cortical mantle may also change.
As a consequence , the shape of the income gradient in mortality changed.
As a consequence , thrombocytopenia was nearly absent in young people and its prevalence increased regularly during lifetime.
As a consequence , to provide a consistent and sufficient energy a high steady-state demand of metabolism is required by the heart.
As a continuation of these studies , here we investigated in detail a panel of pan-mTOR inhibitors , to determine their optimal gerosuppressive concentrations.
As a contribution to the methodology of such studies , we introduce a novel approach to quantifying the covariation between teeth and mandible.
As a control , EEG recordings were also performed in @number@ normal elderly and in @number@ mild Alzheimer's disease subjects.
As a control group , we followed cirrhotic patients ( n = @number@ ) remaining tumor-free over a similar time frame.
As a control group we used @number@ healthy individuals.
As a control , non-fallers were matched at a 3 : 1 ratio.
As a control , @number@ healthy Japanese subjects were enrolled.
As a disease , obesity has deleterious effects on metabolic homeostasis , and affects numerous organ systems including heart , kidney and the vascular system.
As adults with type @number@ diabetes age and develop multiple comorbid health conditions , they may experience many challenges to good diabetes care and self-management.
A safe range of 20-40 ng / mL was identified for serum calcidiol.
A safety TUVRP could improve their voiding function and activities of daily living.
As a final step , theoretical implications of the results are discussed , before accepting the selected model.
As a final step , we identified a risk profile from representative items across instruments selected through variable reduction techniques.
As a first step , participants received the film clips in each of @number@ unimodal conditions ( facial , lexical , prosodic ) .
As a frame the social-ecological model ( McLeroy ) was used , distinguishing factors at the intrapersonal , interpersonal , and community level.
As a function of force level , efficiency followed an inverted-U shape in both groups , suggesting a similar organization of the force control system.
As age increased , ϵ2 carriers showed elevated FC , whereas ϵ4 carriers exhibited decreased FC.
As age increased , APOEε2 carriers showed stable AFC , whereas APOEε4 carriers exhibited decreased AFC in all participants.
As age increased , severity of difficulty swallowing decreased.
As age increased , these symptoms received lower average distress ratings.
As age increases , immune responses and consequently protection following vaccination to seasonal influenza is commonly believed to decrease.
As age increases so does physical vulnerability , age-related impairments , and the risk of being involved in a fatal crashes.
As age increases , the brow changes its shape and position.
As ageing is associated with some reduction in first-pass metabolism , bioavailability of a few drugs can be increased.
As a general trend , the sex- and age-specific incidence rates of dialysis decreased gradually between @number@ and @number@ except among men aged ≥80 years.
As aging is associated with increased fat , especially abdominal visceral fat , the cutoff value of WC may differ according to age.
As aging of childbirth advances in Japan , women who plan pregnancy would increase after they developed RA.
As a group , older adults report positive affective lives.
As a group , these active participants achieved better episodic memory , sustained attention and psychomotor speed results.
As AIDS-related mortality is decreasing , persons living with HIV are aging , their life expectancy tending to reach that of the general population.
As all European member states are facing an increasing complexity of health and social care , good practices in ICT should be identified and evaluated.
As a lump sum scores of toxic and potentially toxic substances are detected in a human body that significantly affect health and human lifespan.
As a marker of cellular death , cell-free DNA ( cf-DNA ) has a utility in diagnosis and prognosis of various disorders.
As a marker of systemic inflammation , CRP was measured.
As a matter of course , not only androgen but all pituitary-related hormones are needed for hypopituitarism patients.
As a metabolic regulator , FXR plays key roles in regulating metabolism of bile acids , lipids and glucose.
As a methodological referential the Data Based Theory was used , and the Symbolic Interactionism was used as a theoretical referential.
As a model of aging , we used senescence-accelerated mice to provide new insights.
As among the volunteers , there was no gender or age effect on CRT index for the patients with cirrhosis.
A sample consisted of @number@ normal and @number@ anemic children paired by sex and age.
A sample included @number@ males and @number@ females who had participated in a Chuvashian skeletal aging study.
A sample of blood was collected and mononuclear cells and DNA were isolated and TL measured.
A sample of community-dwelling older people aged @number@ and over were recruited in 2009-2011 , then followed up 2-3 years later.
A sample of @number@ adults ( @percent@ White ; @percent@ Black ) was drawn from the longitudinal Social Relations , Age , and Health Study.
A sample of @number@ adults was drawn from the nationally representative French dietary survey ( Individuelle Nationale des Consommations Alimentaires @number@ @date@ ) .
A sample of @number@ cohabiting spouses of persons diagnosed with probable or possible Alzheimer disease was recruited for this study.
A sample of @number@ individuals from the Athens Collection was used to test this revised aging technique.
A sample of @number@ individuals ( mean age = @number@ ± @number@ years ) was recruited in @number@
A sample of @number@ middle-aged couples reported support they gave to and received from their parents ( n = @number@ ) .
A sample of @number@ participants who completed the study was included in the analyses.
A sample of @number@ participants , with age ranging from @number@ to @number@ years , completed a battery of @number@ face cognition tasks.
A sample of @number@ women aged 15-49 years were recruited by random sampling in Hong Kong , Pakistan and Thailand.
A sample of @number@ young adults rated the relevance of cognitive , reflective , and affective aspects for wisdom.
A sample of women ( aged 60 + ) completed an online survey regarding their intent to communicate with a provider about sexual health.
A sample size of @number@ patients was contemplated.
As a multifunctional protein , visfatin plays an important role in immunity , metabolism , aging , inflammation , and responses to stress.
As an adjuvant means of therapy memantine is considered.
As an aging suppressor , Klotho is an important molecule in aging processes and its overexpression results in longevity.
As an application , we predicted county-level prostate cancer incidence rates and counts for the year @number@ in Connecticut.
As a nation , we face a shortage of individuals to serve our aging population.
As an enzyme , SSAO metabolizes primary amines generating hydrogen peroxide , ammonia , and aldehydes.
As a new hormone , betatrophin has gained attention as a potential new target to combat insulin resistance ( IR ) and diabetes.
As an example , antidepressants have been demonstrated to present neuroprotective and anti-inflammatory properties and to stimulate neurogenesis.
As an example , some changes have required @number@ years to gain global approval.
As an example , the height of the mandibular bone decreases to the position of the mylohyoid line after tooth loss.
As an example we designed and evaluated an application for acoustic user interaction with a multi-media reminder and calendar system.
As an example , we would like to introduce an education program for pharmacists designed to develop clinical reasoning skills for patients ' symptoms.
As an extension of the brain , the spinal cord has unique properties which could allow us to gain a better understanding of CNS pathology.
As animals become older , AEL vesicles become dysfunctional , enlarge and their turnover appears delayed.
As an important effector of this pathway , FoxO is involved in versatile activities that protect organisms from stress and aging.
As an important translational theme , this review will consider possibilities for selectively targeting telomeres and telomerase to enhance cancer therapy.
As an increasingly global village , the ability to share and learn is more easily achievable.
As an initial process of decision making in a real-world agent interaction , familiarity judgment leads the following processes for intelligence.
As an initial step , we determined the effect of Bikram yoga on glucose tolerance.
As an institution in society , nursing can be influenced by such negative discourses.
As a non-drug option Mediterranean diet can be effective.
As a non-invasive \ "liquid biopsies \ " , ctDNA is a potential surrogate for the entire tumor genome.
As an outstanding scientist and physician of Traditional Persian Medicine , Avicenna has introduced an unconventional approach to seniors.
As a novel profibrotic mediator , Egr-1 thus appears to be a promising potential target for the development of anti-fibrotic therapies.
As anticipated , GSLs were higher in dystrophic than in healthy muscles ( P < @number@ ) .
As a part of the Papez circuit , the fornix carries information on episodic memory.
As a population , human HSCs become more myeloid-biased in their differentiation potential.
As a positive control , retinoic acid , one of the top anti-wrinkle effectors , showed a @percent@ improvement compared to the non-treated control.
As a positive predictive factor , depression had the strongest association with AMS.
As a potential pathway involved , expression of cell cycle proteins was assessed.
As a potential therapeutic option for ED , gene therapy might provide an effective means.
As a potent indicator of patients ' safety , delirium provides a target for system-wide process improvements.
As a prerequisite to the development of these strategies , we must improve our fundamental knowledge regarding IVD pathophysiology.
As a psychological phenomenon , it has typically been defined in Western research literature as the discrepancy between desired and actual interpersonal relations.
As a quantitative measure of healthy aging , we used a frailty index , called FI34 , based on @number@ health and function variables.
As a redox-sensitive protein , HMGB1 contains three cysteines ( Cys23 , @number@ and @number@ ) .
As a reference group @number@ @number@ ± @number@.0-year old healthy subjects ( @number@ women , @number@ men ) were recruited.
As a response , the World Health Organization ( WHO ) introduced the concept of ' age-friendliness ' in @number@
As a restorative process , sleep is important for supporting immune function and aiding the body in healing and recovery.
As a result , a comprehensive effort to decrease falls begins with a review of medications.
As a result , adults around the world are recommended to undertake regular PA of either absolute or relative intensity.
As a result , a full set of new dentures may not always be the ultimate goal.
As a result , age at onset and motor and non-motor features of LRRK2-PD patients were similar to IPD patients except for milder non-motor symptoms.
As a result , a growing need exists to understand the factors that promote mental and physical health in older populations.
As a result , a number of promising international prevention trials are currently ongoing.
As a result , bacterial phagocytosis in aging AMϕ is decreased.
As a result , cells increase their antioxidant capacities and decrease the risk of cancerous transformation.
As a result , characterization of muscle pathology , especially in the heart , has proven difficult.
As a result , clusters of areas characterised by extreme indexes of longevity could be identified and the temporal evolution of the phenomenon depicted.
As a result , co-morbidity from non-communicable diseases in those living and aging with HIV is increasingly being reported.
As a result , \ "consolidation \ " pattern of neuronal activity converted to \ "depotentiation \ " pattern of neuronal activity in KI neurons.
As a result , curbing the aging process and preventing cognitive decline associated with aging are increasingly important.
As a result , different trends from reported incidences were observed for liver cancer in males , and trends of registration rates differed by sites.
As a result , estimating neural activity using the canonical hemodynamic response function is inappropriate in a number of contexts.
As a result , healing is rapid and downtime is minimal.
As a result , health care expenditures are expected to increase.
As a result , homogentisic acid cannot be metabolized , causing systemic increases.
As a result , HOS osteosarcoma cells exhibited higher Beclin-1 expression.
As a result , impaired sensory system could induce deterioration of the activities of daily living and quality of life in the elderly.
As a result , individualized reference ranges may provide improved sensitivity in frail , older patients.
As a result , information is obtained on both the thickness and the charge density of the surrounding layer.
As a result in the aged population , there is increased susceptibility to infection , poor responses to vaccination , and increased incidence of autoreactivity.
As a result , in the frequency distribution charts there was a shift from excessive fat to low fat from age @number@ to @number@ years.
As a result , I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts.
As a result , it modulates cell fate decision by p53 in response to DNA damage differently according to the extent of DNA damage.
As a result , LTC use has become better tailored to the needs for such care.
As a result , many neurologists have become cautious when prescribing therapy with LD.
As a result , @number@ studies from PubMed and @number@ studies from Web of Science were retrieved.
As a result of aging populations , institutionalization of older people is creating an increasing financial burden in many countries.
As a result of decreased nitric oxide availability , aging vessels often exhibit endothelial cell senescence and increased oxidative stress.
As a result of endothelial cell function impairment , angiogenic process is strongly inhibited by G4 ligands both in vitro and in vivo.
As a result of increased life expectancy of persons with intellectual disabilities , the number of ageing persons with intellectual disability has increased rapidly.
As a result of the study , the median age was @number@.09±12.74years.
As a result of this growing understanding , several research efforts have launched or will be launching large secondary prevention trials in AD.
As a result of this increased life expectancy , people living with HIV are now at risk of developing other chronic diseases associated with aging.
As a result of using radiation widely in different fields , environmental radiation exposure is increasing as well.
As a result , older cancer patients can experience increased morbidity and mortality.
As a result , oxylipins have been implicated in many conditions characterized by these processes , including cardiovascular disease and aging.
As a result peripheral cytokines penetrate into the brain where they begin to perform new functions.
As a result peripheral cytokines penetrate into the brain where they begin to perform new functions.
As a result , Pin1-deficient mice develop age-dependent tau and Aβ pathologies and neuronal degeneration and loss.
As a result , PLWH increasingly experience the common diseases of aging and the resources needed to manage these comorbidities are increasing.
As a result , primed microglia exhibit an exaggerated inflammatory response to secondary and sub-threshold challenges.
As a result , psychologists are in a unique position to understand and explain the dynamics behind the changing face of retirement.
As a result , seniors ' needs to engage in meaningful activities might remain unmet.
As a result , special operations present some unique metabolic challenges.
As a result , SS-31 protects the structure of mitochondrial cristae and promotes oxidative phosphorylation.
As a result , stress pathways within the endoplasmic reticulum become activated , triggering widespread neuronal apoptosis.
As a result , the absolute prevalence of intentional non-adherence is increased in this population.
As a result , the accurate valuation of life spent in states less than full health will become increasingly important.
As a result , the cortical buckling ratio increased geometrically and reached @percent@ of the reference value in the oldest group.
As a result , the dyshonia severity index ( DSI ) shifts toward negative values.
As a result , the food bolus displays granulometric and rheological properties , the values of which are maintained within the adaptive range of deglutition.
As a result , the frequency of surgery , both elective and emergent , performed on elderly patients will increase.
As a result , the human body burden of aluminum has increased.
As a result , the individual's daily physical activities would have been restricted to some extent.
As a result the inhibitor evacuation stops and restriction point becomes closed a cell enters irreversible proliferative rest.
As a result , the majority of transplant recipients are currently older than @number@ years , and organs from elderly donors are more frequently used.
As a result , the quality of life ( QOL ) in patients with MDS may vary throughout the course of the illness.
As a result there has been discovered a dependence of Altaians ' antioxidant system upon geographical and climatic conditions , and age.
As a result , there is a risk that elderly PWH may miss the chronic disease screening opportunities offered to the general population.
As a result , there is considerable interest in translating these cardioprotective paradigms from the laboratory to patients.
As a result , there is now much more overlap in the capabilities of-and services offered by-each specialty.
As a result , the retinal innate-immune system , particularly microglia and the complement system , undergoes low levels of activation ( parainflammation ) .
As a result , the retired elderly are recommended to take exercise as frequently as possible.
As a result , this physiologically-motivated model enables simulation of specific cochlear lesions such as presbyacusis.
As a result , toilet activities collapse , and with a decrease in drive toilet activities cease.
As a result , unadjusted analysis found that @number@ of @number@ postoperative complications were significantly more likely to occur in patients with IS.
As a result , vascular calcification has been implicated as an independent risk factor in cardiovascular diseases.
As a result , we did not detect any pathogenic mutation of TMEM230 in @number@ probands with familial PD or @number@ sporadic PD patients.
As a result , we found that these glycolytic / MCT-deficient cells resumed growth by redirecting their metabolism toward OXPHOS.
As a result , we identified three hydrolysis sites in AAT.
As a result , we revealed that modern Japanese food is useful for health maintenance compared with modern American food.
As a secondary magnetic resonance imaging ( MRI ) abnormality , we have seen conspicuous common involvement of the subcortical white matter in @percent@.
As a secondary objective , the influence of cancer , obstructive lung disease , smoking and previous weight loss on these associations was examined.
As a second step , participants were presented with tasks that contained different combinations of these modalities.
As a source of mitochondrial DNA for future generations the mitochondria in the female germ line undergo dynamic quantitative and qualitative changes.
As a specific feature of piracetam , beneficial effects are usually associated with mitochondrial dysfunction.
As assessed by gene expression microarrays , more genes are regulated by αTP than by αT.
As assessed by the COPE , older adults reported lower levels of dysfunctional coping strategies than younger adults.
As a starting point in testing this proposition , the authors examined selective attentional processing bias to fall-relevant stimuli among older adults.
As a thin filamentous structure , a Lambl's excrescence is better detected and characterized with transesophageal than with transthoracic echocardiography.
A satisfaction survey was also sent to all patients.
As a tutorial , a trajectory of a @number@ ns MD simulation of the Kv1.2 channel is also distributed with the toolkit.
As average life expectancy increases there is a greater focus on health-span and , in particular , how to treat or prevent chronic age-associated diseases.
As a whole the data obtained by us confirm the assumption that polymorphism of cytokine genes can influence on human lifespan.
As a woman propagates , this circular interaction is then transmitted to the next generation.
As baby boomers age , social work leaders predict there will be a significant shortage of gerontological social workers to care for the older population.
As balance decreases during the process of aging , knee proprioception has a critical role in body balance and daily activities.
ASBIs represent a novel class of candidate therapeutic agents for Alzheimer's disease.
As bones are levers for skeletal muscle to exert forces , both are complementary and essential for locomotion and individual autonomy.
As breathlessness increases , treatment is stepped up from short-acting to long-acting bronchodilators supplemented by non-pharmacological interventions such as pulmonary rehabilitation.
A scalable anatomical model consisting of @number@ degrees-of-freedom was used to compute kinematics and joint moments from motion capture and force plate data.
A scalable anatomical model consisting of @number@ degrees-of-freedom was used to compute kinematics and joint moments from motion capture and force plate data.
As cardiac stem cell properties are also altered with age , autologous stem cell-based therapy to treat heart failure will benefit from new improved strategies.
As cardiovascular risk increased the rates of lipid control according to LDL level dropped.
ASC are most likely localized at perivascular sites in adipose tissues and retain the capacity to differentiate into multiple cell types.
ASC complicated @number@ procedures ( @percent@ ) .
Ascending aortic diameter was recorded in M-mode above the sinotubular junction.
As centenarians well represent the model of healthy aging , there are many important implications in revealing the underlying molecular mechanisms behind such successful aging.
A Schirmer test was feasible only in @number@ patients.
A scientific symposium was held that reviewed emerging research and discussed methodological concerns in applying the life course approach.
As CKD progressed , the serum concentrations of Klotho and sclerostin were inversely correlated with the levels of phosphorus and parathyroid hormone.
As climate change alters environmental conditions , the incidence and global patterns of human diseases are changing.
As climate change proceeds at an unprecedented rate , concern for the natural environment has increased.
As clinical parameters are studied and optimized , enhanced efficacy and consistency of clinical improvement is expected.
As cognitive abilities change with age , questions arise concerning the usage and interpretation of IATs for people of different age.
As communities become more diverse and older people have increasing commitments on their time , new ways to engage prospective participants are urgently needed.
As compared to control , patients with liver cirrhosis showed a significantly higher serum level of Trx.
As compared to those without dementia , those with dementia identified fewer letters on the visual task.
As compared with CORT , plasma 5HT was slightly elevated in smokers but was reduced in patients with COPD.
As concepts are abstract they are difficult to transform into practical work.
As constraints were added , model fit deteriorated slightly.
As control group counterparts , older non-diving females and young non-diving females were compared with older haenyeos in the controlled experiments.
Ascorbic acid and its relationship with periodontal disease are very well known.
Ascorbic acid plays an important role in the aging process , and in the maintenance of periodontal health in the elderly.
A score of ≥16 at follow-up was used to define incident depression.
A score of ≥3 on the 8-item Center for Epidemiologic Studies Depression Scale was used to define clinically relevant depressive symptoms.
A score of @number@ had a @percent@ negative predictive value for frailty while a score of @number@ had a @percent@ positive predictive value.
A score of @number@ in the MMSE ( blind ) ( out of @number@ ) identified @number@ ( @percent@ ) of them.
A score of ⩾ @number@ on the Center for Epidemiological Studies Depression-10 scale indicated depressive symptoms.
A score of ≥ @number@ was considered as OA.
A score of @percent@ or higher on a domain was considered to indicate high methodological quality.
A score of the Behavioral Inattention Test < 129 or of the Catherine Bergego Scale > 0 defined the presence of spatial neglect.
A scoring system determined from lateral radiographs quantitatively assessed degeneration of cervical intervertebral discs.
A scoring system was established based on the analysis.
A screening and diagnostic algorithm was proposed by the European Working Group on Sarcopenia in Older People ( EWGSOP ) .
ASCs were found to differentiate into adipocytes , chondrocytes , osteocytes , and neurons.
ASCs were found to secrete high levels of neurotrophic factors such as NGF , BDNF , IGF-1 , and VEGF.
As current antidepressant pharmacotherapy is less than optimal , understanding the role of sex in pharmacokinetics may substantially contribute to a gender-based optimized treatment.
As current RA treatment guidelines strongly emphasize early and aggressive treatment aiming at fast remission , optimal measurement of inflammation becomes increasingly important.
As cutaneous oncocytoma is exceptionally rare , this tumor is uncommonly encountered by dermatopathologists.
ASC were then tested in a mouse model of limb ischemia.
As demonstrated by bioactivity experiments , TAT-Cygb exhibited a high specific peroxidase activity up to ( @number@ ± @number@ ) U / mg.
As dermatologists are the primary health-care providers for psoriasis , adequate knowledge of comorbidities helps in choosing the appropriate therapy as well as timely intervention.
ASD , however , is not confined to child and adult psychiatry.
As docking units , they influence the recruitment of the transcriptional machinery , thus establishing unique gene expression patterns that ultimately promote different biological outcomes.
ASD provides a model for DSME that may reduce frailty of participants and increase their capacity for physical activity.
A seamless transition into a dedicated young adult service results in reduced premature failure rates of kidney transplants and improved clinic and medication adherence.
A search in PubMed and EMBASE revealed @number@ bond-strength tests reported on in @number@ papers.
A search of MEDLINE , Scopus , and Web of Science was performed from its inception through @date@ .
A search was performed using PubMed , MEDLINE , and EMBASE.
A second , age-related but non-amyloid process likely contributes to medial temporal lobe tangles.
A secondary aim was to assess the degree of agreement between methods for AT determination.
A secondary aim was to characterize the global and regional progression of WMH.
A secondary aim was to determine the agreement between serum and salivary measurement of steroid hormones in ageing men.
A secondary aim was to determine which health and demographic factors were associated with participation restriction.
A secondary aim was to examine the clinical and demographic predictors of depressive symptoms across these groups.
A secondary aim was to investigate the effect of aerobic fitness on sensory nerve-mediated vasodilatation in young and aged skin.
A secondary aim was to investigate the relationship between different individual criteria and low physical performance capacity.
A secondary analysis included women who reported any hot flushes ( n = 349 ) .
A secondary analysis of data was conducted using results from a survey of adult cancer survivors.
A secondary analysis was conducted with a longitudinal sample of aging women ( Kwan , Love , Ryff , & Essex , @number@ ) .
A secondary data analysis of the continuous 2-month nighttime bed sensor data was reviewed for measurable change during a dance study.
A secondary goal was to evaluate participants ' quality of life and nutritional status according to their dietary patterns.
A secondary hypothesis was that TTC would improve cognition , self-reported health status , gait , and balance.
A secondary objective is to use this index to examine gender and socioeconomic differentials in the health status of older people.
A secondary objective was to analyze the safety profiles of both injection techniques.
A secondary objective was to document and compare the time required to complete and score each assessment scale.
A secondary objective was to systematically review / summarize the related observational epidemiologic literature.
A secondary outcome was mortality.
A secondary purpose was to test the instrument's psychometric properties.
A secondary yet equally important purpose is to suggest priorities for future research and knowledge translation based on gaps identified.
A second branch of the WHI in women with prior hysterectomy found an even stronger correlation between estrogen supplementation alone and stroke incidence.
A second cohort included @number@ subjects [ @number@ cognitively normal and @number@ amnestic mild cognitive impairment ] recruited in Montreal.
A second electron reduces oxygen to hydroperoxyl radical , releasing ATP from the active site.
A second examination will be scheduled after @number@ months to assess changes in functional abilities , cognitive functions , and frailty status.
A second exploratory study evaluated histological / histochemical markers in @number@ subjects after @number@ weeks of either retinol or vehicle use on contralateral dorsal forearms.
A second group of participants with similar physical characteristics to the first group was used to evaluate the equations.
A second ( independent ) cohort of @number@ same-sex twins ( @percent@ female ) from the Swedish Twin Registry was similarly examined.
A second meta-analysis then considered the gap between twin-based versus SNP-based heritability derived from population-based GWAS studies.
A second mixed effects model compared the durability of training gains between the MCI subtypes across @number@ years.
A second model explored interaction between job demand and physical ability.
A second-order , linear model was used to fit the force / displacement data.
A second phase involved the use of the PACSLAC and PACSLAC-II by LTC staff to solicit feedback from health care providers.
A second PiB scan was obtained at follow-up in @number@ subjects and a third scan after @number@ years in @number@
A second population is transcriptionally active in the nucleus , and a third population localizes to the outer mitochondrial membrane.
A second postal questionnaire was used to collect data from relatives of the elderly patients suffering from chronic pain.
A second pretest was conducted in India to validate the modified assay protocol , using @number@ quality control specimens.
A second PubMed search identified articles that were cross-referenced under non-infectious or infectious , and search terms relating to social variables.
A second purpose was to determine whether negative emotions mediate the hypothesized link between risky family processes and diminished telomere length.
A second round of rheological experiments was used to identify a preferred GPC formulation for each model glass composition.
A second sample of @number@ cognitively normal participants was recruited in 2008-2009 in the same institution.
A second STM binding task used random polygons and non-primary colors instead ( Experiment @number@ ) .
As economies grow , there should be greater investment in pharmaceutical care , looking to the policies of high-income countries to increase efficiency.
A section of the questionnaire was oriented toward health issues.
A secular increase in use of multivitamins , vitamin D , folic acid , and fish oil across same age group was noted.
A secular trend in height was found , with younger subjects significantly taller than older ones.
A sedentary bout was defined as a period of time > 5 min.
A sedentary break was defined as an interruption in sedentary time ( ≥ @number@ counts per minute ) .
As education increased , so did all three FBCP.
As elderly move to long-term care facilities , they experience changes in gut bacteria that might exasperate the underlying conditions such as osteosarcopenic obesity.
A selection of upper body variables sensitive to impaired upper body control in PD and four acceleration realignment methods were compared.
A self-administered instrument was completed by @number@ DCWs within @number@ NHs in the north Texas region.
A self-administered lifestyle questionnaire was conducted.
A self-administered questionnaire including questions on joint disorders was used at both evaluations.
A self-administered questionnaire of health status , psychological status and questions regarding falls were collected.
A self-completion questionnaire assessed demographic characteristics , current neighborhood and regional evaluations , self-evaluations , expectations for the future , and current and expected QoL.
A self-management program could be one approach to address these complex needs , including secondary complications.
A self-reported baseline survey was given to @number@ community-dwelling older people aged ≥65 y in Japan in @number@ and @number@ ( @percent@ ) responded.
A self-report survey was administered at baseline and again at the end of program instruction.
A semiautomated parcellation program ( Freesurfer ) was used to generate regional cortical volumes from structural MRI scans.
A semiquantitative approach was used to score the staining extent of tissue slide.
A semi-quantitative assessment of the CML expression in the microvascular endothelium and dermal fibroblasts was performed.
A semiquantitative evaluation of BrM lipid deposition is possible by measuring PFO / D4-GFP fluorescence intensity.
A semi-structured interview format based on an interview guide was used to conduct three focus group discussions with @number@ participants.
A semi-structured interview was administered to survey the presence of sensory impairment.
As endothelial dysfunction is associated with preeclampsia , we assessed retinal flicker response during pregnancy and postpartum.
A senescence-associated β-galactosidase ( SA-β-gal ) staining kit was used to assess senescent cells.
A sensitive , effective way of regulating NKCC1 protein expression has significant biotherapeutic possibilities.
A sensitivity analysis of coronary artery calcification by electron beam computed tomography was performed on @number@ patients.
A sensitivity analysis showed that this result was robust over a wide range of mechanical and geometrical properties.
A sensitivity analysis was conducted in a subset of participants matched according to sex , muscle mass , and body size.
A sensitivity analysis was conducted to repeat the secondary analysis in patients taking statins for durations of @number@ @number@ and @number@ years.
A sensitivity analysis was performed to account for influential outliers for the outcome variable ( incident diabetes ) and the model was re-run.
A separate analysis showed that prevMM was significantly higher in women than men ( sign test , p = @number@ ) .
A separate analysis was conducted on all HIV-infected inmates incarcerated between @number@ and @number@
A separate group of AD mice and NT mice were evaluated neurohistologically at six weeks after TBI.
A separate group of @number@ fertile , normoovulatory volunteers aged 22-47 yr served as controls.
A separate pool of Trx-1 forms a complex with apoptosis signaling kinase @number@
Aseptic implant loosening due to inflammatory reactions to wear debris is the main reason for the revision of total knee replacements ( TKR ) .
Aseptic loosening at alloy-cement interfaces constitutes a main failure mechanism of cemented total hip replacements ( THR ) .
A serially passaged model was generated to investigate the role of aging , but was also insufficient to drive tumorigenesis.
A Serial Sevens Test was used as the cognitive load.
A series of candidates for the histone H3 peptide based LSD1-selective inhibitor were designed and synthesized.
A series of hierarchical regression models were specified to examine predictors of cancer pain knowledge and experience.
A series of linear regressions was conducted to examine the relationship of age and cognitive functioning and clinical variables and cognition.
A series of logistic regression models was estimated to identify reasons for dental non-attendance across different welfare-state regimes.
A series of multilevel models were assessed with statistical package SAS @number@ among @number@ Chinese adults aged @number@ or older.
A series of multiple linear regression models were constructed to assess the influence of demographic variables on mean NYU Paragraph Immediate and Delayed Recall scores.
A series of @number@ patients underwent myoablation as the sole procedure with encouraging results.
A series of @number@ phototype III women aged 31-46 years completed a 100-month survey.
A series of @number@ shoulder maneuvers was used to assess shoulder mobility and pain.
A series of observations showed that a dysfunctional clock may underlie the disordered rhythms in AD.
A series of papers reporting age-related changes in DNA methylation profiles in peripheral blood have already been published.
A series of quinolyl-thienyl chalcones were tested against MAO-A and B. Among the screened compounds , most of them revealed potent MAO-A and B inhibition.
A series of simulations show how the performance patterns observed across adulthood emerge naturally in learning models as they acquire knowledge.
A series of systematic reviews were conducted to gather age-sex-specific epidemiological data for RA prevalence , incidence and mortality.
A series of ureas was prepared by reacting mono- or di- isocyanates with 3-amino-1H-1 , 2 , 4-triazole derivatives.
A serious dichotomy currently exists in hematopoietic stem cell transplantation ( HSCT ) and cancer research.
A serious trauma with possible extreme consequences is hip fracture.
A serum UA concentration≥7.0mg / dL in males and ≥5.7mg / dL in females were considered hyperuricemia.
A session of Seated Qigong elicits a hypotensive response with exposure , supporting the notion that repeated sessions may provide advantageous health benefits.
A set of antiplatelet compounds has been selected for HPLC analysis in the different extracts.
A set of evolutionary conserved mechanisms known as mitochondrial quality control ( MQC ) is involved in recognition and correction of the mitochondrial proteome.
A set of indicators has been developed to evaluate strategy implementation.
A set of @number@ miRNAs was consistently regulated in all three subgroups.
A set of principles guiding the technique intended to promote successful cellular engraftment is presented.
A set of sensitivity analyses was performed in order to account for sources of systematic uncertainty.
A set of validated , objective , quantitative scales has been developed in association with experts from different specialties within aesthetic medicine.
A set protocol of questioning occurred following induced syncope to determine the presence of A-LOC.
As evidenced by recent disasters , the imperfections and vulnerabilities of flawed evacuations for older adults are still present.
As evidence for new loci for complex diseases accumulates the assessment of the epidemiologic architecture of these variants in populations assumes higher priority.
As example technologies can empower them to control their health problems , compensate functional disabilities and increase their safety.
A sex effect on pulse pressure trends with age prevails across unacculturated and acculturated populations.
A sex interaction with stronger findings in men requires further confirmation.
As expected , age was statistically significantly associated with both telomere length and BMI adjusted BMD.
As expected an increased rate of mood disorders were related to the risk of suicide.
As expected , associations were found between DQoL scales and the WHOQOL-BREF psychological domain and the GDS-15 , indicating good validity.
As expected , at the individual level , SWB predicted increased longevity.
As expected , both cell types acquired a proinflammatory phenotype , which confirms the validity of our approach.
As expected , cerebrovascular resistance index was increased in the elderly.
As expected , channelopathies are the predominant culprit for hereditary bradyarrhythmias , because they play a crucial role in action potential generation and propagation.
As expected , cohort members who became obese had lower adulthood IQ scores.
As expected , db-cAMP increased PKA- and EPAC-dependent signalling.
As expected , dementia related to both the decline in cognitive and daily functioning.
As expected , for both tests , failure rate increased markedly with age.
As expected for higher-order traits , regions performing a large number of cognitive and affective functions were implicated.
As expected , ginsenoside-Rg5 induced significant concentration- and time-dependent increases in apoptosis.
As expected , handgrip strength test showed differences along ageing only in the fibromyalgia group ( p < @number@ ) .
As expected , HFX demonstrated overt systemic and local muscle inflammation and hypermetabolism.
As expected , in the PAGE study , most SNPs were associated with @number@ or more pigmentation phenotypes.
As expected , IOR developed later in older subjects.
As expected , lesser hippocampal volume and lesser FDG PET metabolism was associated with greater rates of EF and MEM decline.
As expected , mid-age participants showed more diffuse neural activation.
As expected , no age differences were observed in current negative affect ( NA ) for stressors which occurred in the previous 0-10 min.
As expected , older adults used greater muscle coactivation than young adults.
As expected , older adults walked slower ( p = @number@ ) and with increased stride variability ( p = @number@ ) .
As expected , plasma adiponectin was lowest in Inuit children with the most adverse metabolic profile.
As expected , reaction times were different for the young adults between the uni- and the bimanual task.
As expected , recipient age was the main risk factor associated with overall mortality.
As expected , response times decreased and recall performance increased with age.
As expected , results revealed age-related declines in conjunction , but not elementary , search performance ; and in ILF and genu tract integrity.
As expected , results showed that women had worse health than men and that socioeconomic advantage is associated with better somatic health.
As expected , rs429358 associated with metabolic phenotypes in the offspring of the nonagenarian cases from the LLS and their partners.
As expected , rTg4510 mice exhibit profound impairments in hippocampal-dependent learning and memory tests , including contextual fear conditioning.
As expected , secondary control became more important with age.
As expected , SO-VEPs evoked well defined P1 , N1 , and P2 components.
As expected , the best metabolic profile was found in the Low-LAMS / Low-VAT group and the worst in the High-LAMS / High-VAT group.
As expected , the energy consumed are lower in subjects considered as malnourished or at risk of malnutrition.
As expected , the fertility potential correlated positively with decreasing age ( correlation coefficient = @number@ p = @number@ ) .
As expected , the MENO group was older than PERI and controls.
As expected , the older adults performed more poorly on most balance tasks.
As expected , the PPARγ agonist pioglitazone attenuated the surgery-induced inflammatory changes and rescued the associated cognitive impairment.
As expected , the proliferation module was highly associated with decreased recurrence-free survival ( RFS ) .
As expected , there was a steady improvement of memory performance as a function of repeated learning regardless of age.
As expected , the TUG duration was higher in the FG than in YG.
As expected , those centers with more meal times covered on their menus had a greater degree of coverage of requirements.
As expected , TL in patients with DC was significantly ( p < 0.01 ) shorter in all tissues compared with other IBMFS.
As expected , TP53 gene was under significant selection pressure in mammals , owing to its major role in tumor progression.
As expected , we found decreased responses to vaccination and an overall down-regulation of immune components in aged individuals regardless of CMV status.
As expected , we found that vertebral strength decreased with age 2-fold more in women than in men.
As far as regulation of energy balance is concerned there is recent evidence that EE rather than body weight is under tight control.
As far as reproduction is concerned , aging is characterized by a significant limitation of fertility in both sexes.
As far as we are aware , no epidemiologic studies have assessed female reproductive health effects in relation to paraben exposure.
As far as we know , these appliance have not undergone either safety or efficacy testing.
As for acute phenoptosis , it is apparently controlled by receptors responsible for measuring key parameters of homeostasis.
As for facial ecchymosis and hematoma around the needle injection track , only two patients in the active treatment group displayed minimal ecchymosis and hematoma.
As for infection routes , QDS was predominant in paid blood donation , blood transfusion infection , intravenous drugs.
As for laws on women's healthcare , revision allows adaptation to fit changes in the times.
As for sKL , mKL increased TRPV5 current density.
As for the analysis of network effects , no one showed differences between the two groups.
As for the Asian region , referring in particular to China and Japan , @number@ out of @number@ esophageal cancers are squamous cell carcinomas.
As for the human heart , Drosophila heart function also deteriorates with age.
As for the latter the recently realized small world network characteristics representing optimal conditions for information processing may be of particular importance.
As for the translucency changes by aging , limited differences were reported in human dentine , while those for enamel proved to increase.
As for the use of tobacco it was observed a decrease of @percent@ in postoperative period.
As for the whole human body , the kidney undergoes age-related changes which translate in an inexorable and progressive decline in renal function.
As frailty progresses , individuals face an increasing frequency of acute health issues requiring medical attention.
As glutamate is the neurotransmitter in this synapse , excitotoxic phenomena may participate in afferent and ganglion neuron damage.
A shallow perifoveal posterior vitreous detachment developed in @number@ of @number@ eyes ( @percent@ ) of subjects aged > 51 years.
A sharing dementia care knowledge model was conceived , with the PWDs and their care partners at the centre.
A sheet of choroid plexus epithelial cells extends into each cerebral ventricle and secretes signaling factors into the CSF.
A shift in colon feces microbial community composition was observed by fatty acid methyl ester analysis.
A shift in expression of smLRP1 relative to LRP1 towards smLRP1 was observed in most tumour cell lines compared to healthy tissue.
As HIV-infected patients are aging , they are at increased risk for comorbid diseases.
As HIV infection has become a chronic one , new challenges have emerged.
As HIV-positive populations are aging , additional attention should be given to the reproductive health of these women.
As home-visit nursing plays a major role in home health services , the Japanese government began promotion of this activity in @number@
A shortcoming of cross-sectional studies , however , is that subjective assessments may rely on different individual standards , which are not taken into account.
A shorter distance indicates deeper aortic wedging.
A short exposure to midday sun will result in sunburns.
A short form , the Mini-BESTest , was developed as a screening test.
A short-term BP-lowering drug therapy was conducted according to current Brazilian guidelines on hypertension , and basal cytokine levels were measured before and after intervention.
A short-term treatment with beta-blockers was introduced for symptomatic relief.
A short treatment period may thus be adequate in Japanese hypogonadal patients as regards symptomatic changes.
A Shouwu pill group and young group were used as controls.
As human erythrocytes age during storage in blood banks they undergo many biochemical and structural changes , termed the red blood cell ' storage lesion'.
As humans live longer , the precise modeling of mortality curves in very old age is becoming more important in aging research and public health.
Ashwagandha ( Withania somnifera ( L. )
As hypothesized , prevalence of SA-MCI exceeded that of MA-MCI.
Asia is made up of a great number of ethnicities.
Asian blepharoplasty will not be covered.
Asian females also show a predominantly granular or central pattern of calcification that may hinder proper harvest and incision of the rib cartilage.
Asian / Pacific Islanders had the highest rates of hyperlipidemia , abnormal blood glucose level , and diabetes.
Asians appear to have less severe manifestations , with milder orbital edema , proptosis and muscle restriction.
Asian time-tested wisdom on a balanced healthy lifestyle to longevity should be explored as potential men's health promotional programs.
A side effect of several medications is causing xerostomia and hyposalivation , and both the type and number of medications used are relevant.
Aside from diagnostic dilemmas , there are numerous subtle advantages and disadvantages of the various testosterone agents to appreciate.
Aside from its roles in as a classical neurotransmitter involved in regulation of behavior , noradrenaline ( NA ) has other functions in the CNS.
Aside from the clinical risks of delayed and out of hours surgery , such practices incur significant additional costs.
Aside from their established clinical applications , recent studies have suggested neuroprotective effects of T-type calcium channel blockers.
Aside from variation in the prion protein gene , genetic risk factors for sporadic Creutzfeldt-Jakob disease remain elusive.
ASI for intractable secondary pneumothorax can be applicable to selected patients with deteriorated general condition.
A significant Age × Condition × Task interaction emerged , but this result could not be attributed to a specific task requirement in post-hoc tests.
A significant age dependency was observed for global longitudinal and 3D strain.
A significant age-hypertension interaction occurred ( P = 0.0009 ) .
A significant and specific association between rs1456031 TT and rs17137124 TT genotypes and verbal fluency scores was reported.
A significant association of SB with higher odds of frailty was found , however this association disappeared after adjusting for cognitive status.
A significant association was also found between SLC25A24 SNPs and body mass index in the @number@ Japanese postmenopausal women examined in the study.
A significant association was also noted between Hsp70 levels and the degree of dependency and cognitive decline in geriatric patients.
A significant association was found after adjustment for age , brain volume and childhood mental ability.
A significant but moderate relationship was also found between psychological well-being , subjective physical health and religiosity , while controlling for social desirability.
A significant change in AT levels could not be shown ( p = @number@ ) .
A significant correlation between dysregulated emotional behavior and connectivity of the sgACC and dorsal medial prefrontal cortex was also found.
A significant correlation between PLMS duration and arousal duration was also found ( r = @number@ P < @number@ ) .
A significant correlation between S-FNAME and Word List from the WMS-III supported convergent validity.
A significant correlation occurred with GSH / GSSG ratio in Child B and C patients.
A significant correlation ( p = @number@ r = @number@ ) was found between BDNF levels and the level of physical activity.
A significant correlation was found between age and scores for both tests in the control group.
A significant correlation was found between homocysteine and folic acid concentrations ( rs = @number@ p = @number@ ) .
A significant correlation was found between the number of nocturnal episodes and sleep quality.
A significant correlation was found only between exposure to cigarette smoke or a history of previous CVDs , such as stroke or myocardial infarction.
A significant correlation was observed between the bilingual proficiency score and lexical memory score ( p < @number@ ) .
A significant cross-level interaction effect between individual- and community-level social capital was also observed.
A significant decrease in cortical width and area was seen ( P = 0.002 and < 0.001 respectively ) , with no difference between sexes.
A significant decrease in intercuspid width , arch depth , and anterior space was observed in both arches of both genders.
A significant decrease in TEWL with acetyl hexapeptide-3 treatment is observed.
A significant decrease in the content of T-cell receptor excision circles and telomere length in patients with ESRD confirmed these phenotypic data.
A significant decrease in the depth of vertical and horizontal glabellar creases was obtained in these patients.
A significant decrease in the μTBS after @number@ months and @number@ yr was observed for the control group only.
A significant decrease in total fat mass was observed in experimental groups.
A significant decrease was found in SF concentration of COMP following exercise , whereas aggrecan , CTX-II and IL-6 remained unchanged.
A significant degree of heterogeneity was observed.
A significant difference in relative BGT-CBF and OC-CBF was shown between infants at 31±2 weeks postmenstrual age and infants scanned at 52±1 weeks postmenstrual age.
A significant difference in the diagnostic yield between group A and group B ( @percent@ vs. @percent@ , P = 0.04 ) was shown.
A significant difference in the mean ages was not observed when comparing evaluators.
A significant difference was also observed in the recovery process of sodium channel from inactivation.
A significant difference was observed in moisture content between the 20- to 39-year-old group and the over 40-year-old group.
A significant difference was obtained in the intervention group regarding mental health.
A significant distribution disparity in falls between the two groups was found during follow-up and showed a relative risk of @number@ for EE of MSL.
A significant dose-response relationship was present between severity of depressive symptoms and elevated CVD risk.
A significant evolutionary constraint is seen on the anti-oxidant gene , SOD3.
A significant form of defense is informal sector family-based care.
A significant gap appears to exist in the literature regarding the utility of death conversations outside the end-of-life context.
A significant gap exists between organ supply and demand in the world.
A significant gender effect was observed for the symmetry index of both axes but not for the regularity index.
A significant genetic correlation of @number@ indicated that ME and depression share a significant amount of their underlying genetic variance.
A significant group by condition interaction on accuracy was found , showing a significant congruency effect in younger , but not older adults.
A significant group difference was found in favour of sertraline on the Sheehan Disability Scale.
A significant improvement in NK cell activity of KC-1317 consumers was observed as compared to placebo at the end of @number@ months.
A significant improvement was observed in all the examined patients at all stages of rehabilitation in relation to the baseline values.
A significant increase in adiponectin levels with ageing was observed in both African men and women ( p < 0.01 ) .
A significant increase in center of foot pressure ( COP ) excursion was observed during both head tracking and cognitive dual-task conditions.
A significant increase in chronic age-dependent disorders will soon cause important challenges for several countries.
A significant increase in erythrocytes has been reported in chronic haemodialysis patients and found to be strongly influenced by the uraemic milieu.
A significant increase in IQ was found in the surgical group after an extended follow-up period of > 5 years.
A significant increase in mean SHIM score and a significant decrease in mean AMS were noted.
A significant increase in RPIA expression was detected both in tumor biopsies of HCC patients and in a liver cancer tissue array.
A significant increase in suPAR with age was observed ( p < 0.05 ) .
A significant increase of HA content in skin after @number@ weeks of treatment was observed.
A significant increase of nitrated BVR-A was demonstrated only in AD and MCI hippocampi , whereas no significant modifications were found in cerebellar tissue.
A significant increase of products of oxidative proteins modification in plasma and erythrocytes with aging was discovered.
A significant increase was also observed in the level of apoptotic cells in epidermis over-expressing miR-30a.
A significant increasing trend in body weight across birth cohorts was also observed in the few years prior to death.
A significant influence of other vascular risk factors , such as lipids , diabetes , and smoking , on executive dysfunction was not observed.
A significant interaction between task type and the curvilinear effect demonstrated differential lifespan patterns of performance on each task.
A significant interaction between the REV-ERB-ALPHA1 variant and ( MUFA ) intake for obesity was also detected in the Mediterranean population.
A significant interaction of coffee intake and BMI ( nonlinear ) was also noted for SBP in men.
A significant interaction was found between speed of speech and hearing loss.
A significant interaction was found , with young controls reducing their speeds more substantially while handling the stroller / cart than older participants.
A significant interaction was observed between drinking water inorganic arsenic and periconceptional folic acid use.
A significant inter-arm difference in systolic blood pressure ( IADSBP ) has recently been associated with worse cardiovascular outcomes.
A significant inverse correlation was found between HRV and both the severity of depression and the duration of the depressive episode.
A significant inverse correlation was found between increasing age and decreasing half-time of emptying in men and women ( P < @number@ ) .
A significant lower appendicular lean mass index was observed in osteoporotic women ( p-value = 0.025 ) .
A significantly greater improvement in depression symptoms was always apparent in patients on SSRIs with all selected indicators.
A significantly higher cycle cancellation was noted in the low AMH group than the normal AMH group ( @percent@ vs. @percent@ ) .
A significantly higher percentage of subjects with FCD Type IIb versus Types I and IIa were seizure-free after surgery.
A significantly higher proportion of females ( @percent@ ) compared to males ( @percent@ ) met these dairy requirements ( P = 0.011 ) .
A significantly higher proportion of those under age @number@ years was found to have clinically significant depressive symptoms and probable MDD.
A significantly higher rate of adverse events was observed in the GH groups.
A significantly increased incidence of chronic active inflammation of the nose occurred in @number@ g / kg males.
A significantly larger number of older patients lived alone and needed aids to walk before the injury ( p < @number@ ) .
A significantly lower percentage of older adults with bothersome pain and severe physical limitations reported meeting rehabilitation goals.
A significantly positive relation between ( ( V ) O2max and FPG-sensitive sites was verified.
A significant main effect for age was observed across all variables whereby pharyngeal wall thickness decreased and pharyngeal lumen area increased with advancing age.
A significant main effect for time was detected in Bone ALP to CTX ratio for the exercise groups ( p < @number@ ) .
A significant negative association between depression symptom severity and meaning in life was observed at lower but not the highest levels of spirituality.
A significant negative association ( P < @number@ ) between the risk of malnutrition and index of quality of life was found.
A significant negative correlation between T / S ratio and percentage of time was observed.
A significant negative correlation of DKK-1 levels and age was observed ( r = @number@ p < @number@ ) , but not for sclerostin.
A significant negative correlation was also found between TAS level and BMD values for the spine in OP patients ( p < 0.035 ) .
A significant negative correlation was detected between the nucleocytoplasmic ratio of the somatotropes and cross-sectional areas of types @number@ and @number@ muscle fibers.
A significant negative correlation was found between age and maximum head velocity ( r = -0.469 , p < @number@ ) .
A significant negative correlation was found between serum LH / FSH ratio and age ( r = @number@ P < @number@ ) .
A significant number of mutations and polymorphisms were common between RTS and LFS patients.
A significant number of older asthmatics , more often than in previous ages , have poorly controlled asthma , leading to increased morbidity and mortality.
A significant number of these are chronic degenerative neurological disorders.
A significant part of the variability of the QoL could be explained by the posturography outcome ( @percent@ ) .
A significant ( p < @number@ ) decrease in ( - ) epicatechin uptake by human erythrocytes was observed as a function of age.
A significant pooled variant association across the hypervariable @number@ region was observed for AEE and PAL.
A significant portion of these compounded analgesic preparations is made up of topical / transdermal dosage forms such as gels and creams.
A significant positive association between plasma NEFA and incident diabetes was observed during the first @number@ years of follow-up.
A significant positive association between vitamin D level and gait speed was found only in those with high CRP in stratified analyses.
A significant positive correlation between AMH and LH concentration was seen over the 24-h period ( P < @number@ ) .
A significant positive correlation between attentional bias and amygdala activation was also present , but this relationship was mediated by PFC activity.
A significant positive correlation between cross-sectional area and twitch parameters was found for the plantar flexors in young adults when using supramaximal doublet stimulation.
A significant positive correlation was found between the obtained financial extravagance score and regional gray matter volume in the caudate nucleus.
A significant positive correlation was observed between α-Klotho and FGFR1 ( r = @number@ P < @number@ ) .
A significant positive correlation was present between the percentage of MUC1-positive cells and disc grade ( p = @number@ ) .
A significant positive relationship was observed between the SASS total score and PFC activation.
A significant proportion of never drivers also used public transportation and van / shuttle services , whereas a smaller proportion of ex-drivers used them.
A significant proportion of post-menopausal , patients treated with AI reports side-effects , especially bone pain.
A significant proportion of TEMRA cells remained depleted for ≥3 months in patients.
A significant proportion ( @percent@ ) of the women were said to have had personal experience with homebirth.
A significant reduction in skin wrinkling was noted for date kernel extract , cork extract , soy extract , Rosaceae and peony extract.
A significant reduction in smell identification ( UPSIT ) was found between patients with TEA and healthy controls ( p < 0.001 ) .
A significant reduction in thresholds from the first to the last keyword was interpreted as indicating that stream segregation improved with time.
A significant relation between the MEDAS and MMSE scores was found.
A significant relationship was found between lower BMD and higher total cholesterol , triglycerides and LDL levels , but not HbA1c.
A significant relative expansion of extracellular water against total water was observed in the elderly requiring care.
A significant rising trend during 1999-2006 was followed by a drop during 2006-2010 in age-adjusted rates for urban females.
A significant role in MetS is played by the stress response and cortisol.
A significant sense of powerlessness in the situation was experienced by the health care professionals.
A significant sex difference was found only in the onset age of gastrocnemius deterioration , which was earlier in men than in women.
A significant small effect ( d = @number@ ) in favour of the IG was found for psychological health-related quality of life.
A significant third annual booster effect was one-half the size of the training effect.
A significant weak correlation was noted between OATP1B1 abundance and age of human donors , whereas expression of the OATPs investigated was independent of sex.
A significant worsening over time was observed for verbal memory , visual attention , and processing speed.
A similar analysis of cFGF23 and iFGF23 does not suggest enhanced biodegradation of iFGF23 induced by iron deficiency.
A similar analysis was conducted for older patients achieving HbA1c ≤6.5 % in the initiation phase.
A similar association between cerebellar integrity and function is true for cerebellar patients.
A similar association was found between the levels of hs-CRP and the prevalence of MS in the three age groups.
A similar association was observed with fish intake , but additional adjustment for docosahexaenoic acid led to the elimination of the association.
A similar degenerative pattern of the organelles was shown in germ cells and Sertoli cells in the aging testes under TEM.
A similar effect on marital satisfaction was found for wives who gave more support to their living parents than their husbands.
A similar inhibitory effect was observed in vivo as axon regeneration was impaired after transduction of sensory neurons with KIAA0319.
A similar match for external validation of SNP-SNP interaction studies is suggested.
A similar normal pattern of orienting was observed for involuntary orienting.
A similar pattern and threshold were identified in the analyses of the relation between testosterone and hsCRP.
A similar pattern of change in protective efficacies was observed in human tissue.
A similar pattern of results was seen for systolic blood pressure , although findings did not reach statistical significance.
A similar pattern was evident within most strata of urologist characteristics , including academic affiliation.
A similar pattern was found for cause-specific mortality.
A similar pattern was identified in the last hospitalization before death.
A similar pattern was noted for n-3 HUFA : n-6 HUFA among women.
A similar pattern was observed for fatigue.
A similar pattern was observed when comparing AMS scores between the groups.
A similar pattern was observed when financial satisfaction was used as the SES measure.
A similar percentage in each group reported overall satisfaction with abobotulinumtoxinA ( @percent@ in phase I and @percent@ in phase II ) .
A similar percentage of generalists and specialists ( @percent@ and @percent@ ) initiate drug treatment within @number@ month of diagnosis.
A similar performance benefit was also demonstrated for recognition memory performance , although for positive pictures only.
A similar positive pattern of results was obtained for the analysis of coder drift.
A similar process is induced in adult skeletal muscle by functional overload and exercise.
A similar protection was also elicited by interference with mitochondrial function , clearly suggesting involvement of energy metabolism in increased cell survival.
A similar relationship was not observed for TNFα expression.
A similar relationship was observed for CBI ratings 4-weeks post-baseline.
A similar senescence response was observed in myoblasts from a patient with a lamin A mutation causing muscular dystrophy.
A similar set of tools is now available for the identification of rare moderate-risk loci and common low-risk variants.
A similar suppression is evident in the right fronto-parietal network , possibly reflecting the patients ' frontal dysfunction and right-lateralized patterns of regional atrophy.
A similar tendency to reduce sway in the ML direction was also observed in older adults during imagery in a challenging stance.
A similar trend was found for MT but not SFT.
A similar trend was found in sagging index for this site alone between subjects with and without YAC extract.
A similar trend was observed in A431 cells endogenously expressing the EGFR and transfected with Znf216.
A similar volume of both fillers was injected.
A simple and effective screening tool should have substantial public health benefit.
A simple and fast time-domain method for the FOG detection was suggested and compared with the conventional frequency-domain method.
A simple and unobtrusive FOG detection system with a small calculation load would make a fast presentation of on-demand cueing possible.
A simple antagonism model suggested age-related differences in Tθ and Tω relations would be magnified if antagonistic torque contributions were included.
A simple educational brochure accompanied by a brief review of its contents may enhance effective use of hearing healthcare services.
A simple linear regression and random coefficient models were selected for CS and LT analyses , respectively.
A simple random sample of @number@ respondents representative of the support group members completed an interviewer-administered questionnaire.
A simple random sampling technique was used to select menopausal women for the study.
A simple screening measure for RBD is desirable for clinical and research purposes.
A simple , short and easy-to-understand information sheet and consent form will contribute to improving the readability and understanding of the older participant.
A simple technique for imaging the human skeleton with a flatbed scanner is presented using the auricular surface of the ilium as an example.
A simplified model was used to estimate the 95th percentile for number of globally sclerotic glomeruli by total number of glomeruli and age.
A simplified multilayer model of human skin was employed to examine the contribution of skin's multilayer structure to the large-wrinkle mechanism.
A simplified protocol was applied in all patients.
A simulation of increased TSPO density exposed minimal effect on variability and identifiability of [ 18F ] -FEPPA VT in WM-ROIs.
A simulation study showed that the estimation and inferential procedures perform reasonably well in finite samples.
A simulation study was performed to assess the bias in estimation of the mean 400-m gait speed using both methods.
As in adults , we observed frequency-specific topographical distributions of sleep EEG power in all subjects.
As increased cerebro-cortical rDNA content was previously reported in Alzheimer's disease , neurodegeneration appears to be associated with instability of rDNA.
As India experiences urbanization and population aging , low overweight and obesity may be short lived.
As indicated by an analysis of center of pressure , there were significant associations between UHR performance and measures of static balance.
As indicated by Lin's Concordance reliability ( pc = 0.82 ) between testing days was high and was supported by a Cronbach's alpha of @number@
As individuals survive with HIV into geriatric age groups , greater clarity on these relationships is essential.
A single-blinded , dermatologist evaluated standardized digital facial images for overall photodamage , erythema / telangiectasias , hyperpigmentation , number of lentigines , and wrinkling.
A single blood sample was obtained from the noninjured control groups.
A single booster session counteracted @number@ months of age-related processing speed decline.
A single bout of acute exercise increases oxidative stress and stimulates a transient increase in antioxidant enzymes.
A single burst is insufficient for LTP induction because it evokes both excitatory and inhibitory currents that partially cancel and limit postsynaptic depolarization.
A single copy of klotho allele KL-VS is associated with longevity , better health , increased cognition , and bigger regional brain volume.
A single degree of freedom model of the human body was used to simulate recovery kinematics following the perturbations.
A single evaluator assessed up to @number@ potential hazards in @number@ home regions.
A single experiment was carried out to evaluate the ability of younger and older observers to discriminate object weights.
A single exposure to low-dose UV-A1 irradiation darkened skin slightly and did not alter matrix metalloproteinase @number@ or type I procollagen gene expression.
A single measurement of plasma phospholipid fatty acids appears reasonable to estimate the risk of heart failure over long-term follow-up.
A single mutant expands clonally and finally replaces the wild-type population of a whole cell.
A single nucleotide polymorphism ( SNP ) in the insulin degrading enzyme gene ( IDE ) , rs3781239 , showed a significant association with AD.
A single qualitative case study design was used to provide in-depth , contextual insights.
A single randomized controlled double-blind trial was published.
A single reviewer conducted the literature search and study selection.
A single session of treatment was performed on Asian patients with light facial lentigines.
A single session of treatment was performed on Asian patients with light facial lentigines.
A single treatment was given with the patient under topical anesthesia.
As initial treatment , novel agents are frequently used since high response rates have been reported.
As in previous studies with young subjects , the degree of beta power before target appearance correlated with reaction time.
As in prior research , age differences were evident in control conditions ; however , age differences were eliminated in the death condition.
As instrument to evaluate the attention process the ANT ( Attention Network Test ) was used.
As insufficient research has been conducted in this field , further prospective studies are clearly warranted.
AS is normally secreted from neuronal cells and can thus exert paracrine effects.
As it has been observed in animal models , COX-1 , COX-2 or both isoforms can contribute to these endothelial dysfunctions.
As it is extremely challenging by defying conventional medication and involving new therapeutically approaches , frailty fully qualifies as a new geriatric syndrome.
As it is independent of technical aids , it may be used within large scale prevention programs.
As its name suggests , VDAC is involved in ion transport as well as adenosine triphosphate and NAD ( + ) transport.
A six-session individual training of LR based on specific positive events was carried out with the experimental group.
A sizable portion of the study participants were classified as stunted , wasted , and / or underweight.
A skilled technician can measure TRF length in ∼130 samples per week.
A skin biopsy showed KS.
Asking about sexual health remains difficult or embarrassing for many primary care physicians.
( A ) Skin photograph.
As klotho is a hormone , treatment with klotho may serve as a novel treatment for EOC.
As levels of haptoglobin ( Hp ) fall , free Hb can cause pathology.
A sliding-window k-means clustering approach was used to assess dynamic connectivity from resting-state functional magnetic resonance imaging data.
As life expectancy continues to increase , Alzheimer's disease ( AD ) has become much more prevalent and as yet there is no cure.
As life expectancy increases and so it does the medical intervention , it is important to highlight the benefits of radiation protection in the elderly.
As life expectancy increases and the total elderly population grows , these issues become increasingly important.
As life expectancy increases , it is imperative that health care providers recognize the importance of safe medication use within an aging geriatric population.
A slight increase in frequency was observed among centenarians of hg H ; however , these findings were not statistically significant.
As long as the drainage is kept unobstructed , most of the pancreatic fistula can be self cured.
As long as the recommended doses are used , concomitant injections of ABO are safe and efficient , with no increase in adverse events.
As longevity constantly increases , the number of elderly patients ( @number@ years and older ) who require anticoagulation likewise rises steadily.
A slower Fa with lower outflow facility supports existence of autoregulatory mechanisms.
A slowing sum score that combines both slowing symptoms predicted all three outcomes.
As LVAD engineering technology evolves , so will the risk-prediction scores.
As maintenance of p53 is regulated by a variety of DUBs , the interaction of DUBs and p53 can affect diseases such as cancer.
A small body of literature also suggests that chemokine-mediated angiogenesis may comprise a contributing factor to BPH / LUTS development and progression.
A small but growing research literature exists within gerontology around geriatric nurse aide / resident communication.
A smaller cohort of @number@ subjects underwent a free-breath multi-b acquisition ( @number@ b values , 0-750 s / mm² ) .
A small fraction of lamins also localize throughout the nucleoplasm.
A small fraction of lamins is also present in the nucleoplasm.
A. small group of women was interested and followed the programme.
A small number lost anisometropia over time.
A small number of women transitioning from perimenopause to postmenopause had significantly greater depression than other female reproductive groups.
A small percentage of the patients on dabigatran will experience serious bleeding or be in need of urgent surgery.
A small percentage of women with cervical HPV infection progress to cervical neoplasia , and the risk factors determining progression are incompletely understood.
A small pool of hematopoietic stem cells ( HSCs ) in the bone marrow is responsible for the lifetime maintenance of these populations.
A small proportion had No Artificial Hydration or No Antibiotic orders in place.
As many as @number@ different loci have already been mapped.
As many different mechanisms are involved , a wide range of models have been developed.
As markers of oxidative stress we measured plasma lipoperoxide levels , erythrocyte superoxide dismutase and glutathione peroxidase activities , and total antioxidant status.
ASM , ASE and ASTF have now been mapped genome-wide by microarray-based methods and NextGen sequencing.
As masters-level competition increases in popularity , MA must find methods to enhance individual athletic performance.
As measures of physical functioning , handgrip strength , physical performance , and level of physical activity were assessed.
As medical technology continues to improve , more people will live longer lives with multiple chronic illnesses with increasing cumulative debilitation , including cognitive dysfunction.
As men age , they lose bone and are susceptible to fracture.
As mentioned above , at least some part of the symptoms and pathophysiology progress with aging or over generation in BAFME.
As mentioned , the present paper provides a critical reflection on van der Klink et al's aforementioned definition of SE ( @number@ ) .
As mice carrying the hypomorphic Gata1 It is estimated that in @number@ Brazil will have the sixth largest elderly population in the world.
As microRNAs-one of the major epigenetic regulators-circulate in plasma , we also advocate their potential diagnostic role in cardiac fibrosis.
A smoking epidemic is developing in the region.
A smoking index based on the seven loci showed monotonic associations with TL , cumulative smoking exposure and time after smoking cessation.
A smoking index ( SI ) based on the @number@ loci manifested a monotonic association with the FI.
As more characteristics of small-scale care were integrated , staff's perceived decision authority was higher.
As more computer literate individuals age , the next-generation elderly are certain to be more technically skilled than the current generation.
As more individuals participate in running-related and cycling-related activities , physicians must be increasingly aware of the common injuries encountered in these pursuits.
As most cognitive aging studies have not taken sensory acuity into account , age-related cognitive decline may have been overestimated.
As motor complexity of the RT task increased ( disjunctive versus choice ) there was greater interference from the perturbation.
ASM was measured by dual-energy x-ray absorptiometry at baseline and follow-up.
As neurodegeneration and impaired neurogenesis promote the nervous system aging process , the identification of neuronal anti-aging is required to raise life expectancy.
As nonreplicative cells age , they commonly accumulate subcellular deficits that can compromise function.
As non-right-handedness was increased only in the semantic group , anomalous lateralization mechanisms might instead be related to frontotemporal lobar degeneration with abnormal TARDBP.
As nucleotide excision repair is absent in mitochondria , this DNA damage can presumably not be repaired resulting in high mitochondrial mutation levels.
As nursing homes become more diverse , recognizing differences in hospice use and end-of-life planning will continue to increase in importance.
A social participation scale measured frequency of participation in @number@ community activities.
A sociodemographic index ( SDI ) was created for each location based on income per capita , educational attainment , and fertility.
A socio-demographic information form and the WHOQOL-BREF and WHOQOLOLD questionnaires were applied for QOL assessment.
As of @date@ FCPP volunteers submitted proposals to @number@ state parties in @number@ states.
As of @date@ , more than @number@ older Americans have completed a CDSMP.
As of @number@ the death rate was @number@ per @number@ populations.
As of this writing , black-white residential segregation in the United States is approximately @number@ % lower than it was in @number@
As of yet , relatively little is known about the role that asymmetries in exemplar-specificity play at the level of explicit memory retrieval.
As of yet , various parameters have been proposed but no gold standard exists.
A solid-phase extraction method with in-cartridge derivatization using O- ( @number@ , 6-pentafluorobenzyl ) hydroxylamine followed by gas chromatography-mass spectrometry was employed.
A solid understanding of the relevant anatomy is imperative as is the awareness of how to best avoid complications.
As one ages , facial aesthetic units slowly become distinct.
As one application of this framework , we give a model for the effect of aging on the process of carcinogenesis.
As one of the largest multihospital studies , our study identified increased morbidity in the oldest old , a growing population.
As one of the most popular mechanisms explaining the aging process , it has been extensively studied in several model organisms.
As opposed to female oogonia , the male germ cells undergo hundreds of cell divisions during the fertile years.
As opposed to this , when the perturbations were predictable , APAs were seen in older adults resulting in significantly smaller CPAs.
As optic disc area influences ONH topography , disc size should to be considered when evaluating optic disc for progressive optic neuropathies such as glaucoma.
As organisms age , cells accumulate genetic and epigenetic errors that eventually lead to impaired organ function or catastrophic transformation such as cancer.
ASOs are receptive to collaborating with researchers on disseminating cancer prevention and control knowledge in their settings.
ASO treatment starting after birth led to a significant decrease in Aβ pathology when assessed at @number@ months.
A sound understanding of the skin is also a prerequisite to any facial rejuvenation procedure.
As our discussions lean toward gel-based approaches , utilizations of these probes in 2D gel-based proteomic analysis of carbonylated proteins are illustrated where applicable.
As our population ages , so do the transplant recipients , and with that comes many new challenges.
As our society ages , neurodegenerative disorders like Parkinson's disease ( PD ) are increasing in pandemic proportions.
As our understanding of the microbiome advances , it is evident that these microbial populations participate in a multitude of symbiotic associations with us.
As ovarian follicle numbers dwindle , the axis enters a state of compensated failure.
As p16 ( INK4a ) is dysregulated in human geriatric satellite cells , these findings provide the basis for stem-cell rejuvenation in sarcopenic muscles.
A spacer graft was also used in @number@ percent of the cases.
AS parameters proved to be predictors of increased VA besides the classic risk factors.
As partial suppression of BACE1 attenuates Aβ generation and AD-related pathology , it might be an ideal target for AD treatment.
As part of a clinical-pathologic project , older people completed a standard odor identification test at study entry.
As part of a needs assessment process in these communities , @number@ individuals , including seniors and younger adults , completed an Age-Friendly Survey.
As part of an ophthalmic examination , anterior segment length ( ASL ) was measured sonographically and calculated as anterior chamber depth plus lens thickness.
As part of any comprehensive social cognition test battery , this approach should allow for a rapid and sensitive assessment of potential FER deficits.
As part of new regulations , in @number@ all communities were required to set up information offices to answer questions about out-patient and in-patient care.
As part of the answer , we offer examples of how providers can use geriatric principles to improve the care of aging HIV-infected patients.
As part of the chronic disease paradigm now widely used for HIV in sub-Saharan Africa , antiretroviral treatment programs emphasize self-care.
As part of the discussion , focus group participants were asked to rank their first four preferences by type of support.
As part of the perioperative management , intraoperative cerebral circulatory management with attention to cerebral perfusion and prevention of postoperative delirium is crucial.
As part of the social environment , significant social support was suggested to ameliorate depression among older adults.
As part of this , a growing number of studies explore the importance of individuals ' personal circumstances on their emplaced experiences and agency.
As part of this expansion , the VA implemented a nationwide toll-free telephone Caregiver Support Line ( CSL ) .
As paternal age increases , it presents no absolute barrier to conception , but it does present greater risks and complications.
A spatial memory task requiring egocentric / allocentric verbal judgments about objects in peri- / extrapersonal space was used.
As PD-related pathology progresses , functional disruptions within the default mode networks seem to be considerably associated with cognitive decline.
A Spearman rank correlation test revealed that age , AMS score , IPSS and hs-CRP levels were significantly correlated with SHIM score.
A Spearman's correlation analysis was also carried out between the single and multi item measure of quality of life to assess how well they correlate.
A Spearman's correlation determined the association between the SCREEN II score and the dietitian's risk score.
A special focus has been placed on the effects on muscle protein synthesis , strength and overall performance in this population.
A special sample preparation was performed , followed by liquid chromatography-mass spectrometry.
A special session , \ "Thinking about Scientific Philosophy , \ " featured presentations by distinguished scientists from Japan and Korea.
A specific adherence questionnaire was developed by the researchers to determine motivators and barriers to exercise adherence.
A specific assessment using geriatric indexes might be the key to success in this population.
A specific circadian rhythm of cortisol hypersecretion pertains at mild-to-moderate AD stages , entailing increased levels at the circadian peak from a low nadir.
A specific inhibitor of p38MAPK , SB203580 significantly decreased the secretion of IL-6 and IL-8 , the major components of SASPs.
A specific landscape of dSWM in early AD shows the potential of MTR imaging as an in vivo biomarker superior to currently used techniques.
A specific management for elderly woman is not clear because clinical trials are usually not customized for this subset of patients.
A specific search filter for use in geriatric medicine was used.
A specific section is dedicated to the striking ability of environmental enrichment and physical exercise to empower adult brain plasticity.
Aspects of caregiver burden correlated with child OCD symptom severity , functional impairment related to OCD , as well as caregiver and child comorbid psychopathology.
Aspects of existentialism relevant to existence and death anxiety ( DA ) are discussed.
Aspects of medicines management targeted included medication review , adherence , and administration.
Aspects of neuroinflammation vary within the context of disease , injury , infection , or stress.
Aspects of successful ageing relate to lifestyle and environment.
Aspects of the physical and temporal environment can optimize and preserve function , or they can impede if not imperil it.
As people age and live for longer they are more likely to develop comorbid conditions including chronic kidney disease ( CKD ) .
As people age , memory and the ability to carry out tasks often decline and their risk for neurodegenerative diseases increases.
As people age , they too experience problems that can accumulate.
As people grow older , speech perception difficulties become highly prevalent , especially in noisy listening situations.
As people with cancer survive longer , and as the US population ages , skeletal effects of cancer treatment are becoming more pronounced.
Aspergillus endocarditis requires rapid surgery and voriconazole.
As persons with HIV infection age , they become at risk for comorbidities that occur in any group of aging individuals.
As pharmacists are in the direct contact with patients they have the most important role in rational and effective use of DSWL.
As pharmacological data sets become increasingly large and complex , new visual analysis and filtering programs are needed to aid their appreciation.
As physical activity is essential for the preservation of function , personalized training and activities are of great importance.
As physical and functional limitations become more apparent over time , expected validation occurs in support of the conventional narrative of decline.
As physical appearance is very much related to desirability , we explore sexual body image and the way that it changes as women age.
Aspirin acetylates many proteins , while reducing phosphorylation , suggesting that acetylation may oppose phosphorylation.
Aspirin intake and covariates were estimated using self-reported questionnaires.
Aspirin use is the main characteristic associated with anticoagulation underuse.
A SPIRIT checklist is available for this protocol.
A spirometric reference equation consists of a mathematical model with constants and coefficients optimized to fit a specific data set from healthy individuals.
As pleiotropic hormones , vasoinhibins act in multiple target organs and tissues.
ASPN clients also have high prevalence of both functional impairments and social morbidities.
As populations continue to grow older , efforts to support the process of aging well are important goals.
As populations in Western civilizations are aging , the prevalence of degenerative aortic valve stenosis is increasing.
As potential modifiers of the impaired innate immunity , some principal nutraceuticals will be illustrated , such as micronutrients , pre-probiotics and polyphenols.
As precipitation of calcium and phosphate is fostered by alkaline pH , extracellular acidosis could counteract tissue calcification.
As predicted and in line with studies applying cross-sectional designs , no advantages associated with bilingualism were found in the categorical fluency task.
As predicted , bilinguals exhibit greater frontal lobe white matter compared with monolinguals.
As predicted , cases had significantly lower cognitive polygenic scores compared to controls.
As predicted , the high-expression allele of rs4727380 was identified as the AD risk allele in both samples.
As predicted , these conditions differ substantially across young and older adults.
As predicted , these differences were greater than differences between targets perceived by younger adults.
As predicted , those in the training condition showed selective improvement in inductive reasoning.
ASPREE will examine whether the potential primary prevention benefits of low dose aspirin outweigh the risks in older healthy individuals.
As previously shown for deletions , imperfect stretches of homology are common in duplication breakpoints.
As proliferation declines with age , the OPT model predicted age-dependent changes in cell-density profiles , which we observed in mouse and human lenses.
As proof-of-concept , we validated SH2B3 , one of the top key drivers , using Sh2b3 ( - / - ) mice.
As proponents and opponents of homosexual rights both depended on constructions of sexual identity to advance their agendas , Kinsey's ideal was never realized.
As proteins , lamins have been suggested to fulfill mainly structural functions such as providing shape and mechanical stability to the nucleus.
As provisions of the Affordable Care Act take effect , implementation programs should expand enrollment efforts to include the conjugal unit and the church.
As recent studies found , even the place and season of birth matter for human longevity.
As reflection of the training program's value , @number@ of the @number@ participants took ownership of the iPad at the end of the study.
As regards the long-term follow-up , an overall satisfactory rate of @percent@ ( 25 / 30 ) was achieved.
As reported previously , discontinuation of risperidone was associated with a two- to fourfold increased risk of relapse over 16-32 weeks.
As result , medial degeneration ( MD ) occurs.
As result of the great benefit of HAART , AIDS-related deaths have dramatically declined during the last decade in HIV-infected individuals.
As results , there is a lack of data about elderly with dementia in prisons.
As resveratrol has been reported to have cardio- protective effects , we investigated its role in VSMC phenotypic modulation.
As retirement age is currently advancing , keeping elderly workers in the workforce is of prime importance.
As revealed by the literature , the attainment of a healthy life could be impacted by the social milieu.
As risk factors , hypertension , diabetes mellitus , and dyslipidemia were much more common in patients with NSTEMI than STEMI.
As ROS / RNS are short-lived molecules , these molecular signatures can thus execute the ultimate function of ROS / RNS.
Assay of the top proteins in human and AD mouse model brain microvessels correctly classified 90-100% of the samples.
Assay range of HEL ELISA was 2-700 nmol / L , and showed good linearity and reproducibility.
Assays for OT , AVP , and creatinine , including freeze-thaw cycles , were refined and validated.
Assays identify a recruitment of the canonical pathway proteins NF-κB p65 and p50 to the CTCF promoter associated with the co-repressor HDAC1 explaining gene repression.
As scaffolding molecules , they significantly regulate the DNA packaging into the nucleus of all eukaryotic cells.
As scientific evidence has shown , individuals who have the lowest level of involvement in social relationships face a greater mortality risk.
As secondary analyses , the relationship between hyperprolinemia and five measures of clinical onset , symptoms and outcome were investigated.
As secondary outcome , the participants ' physical activity and 72-h glycemic responses were monitored @number@ d within each of the periods.
Assembled evidence suggested that improving family planning interventions is cost effective in a variety of L-MICs as measured against accepted international cost effectiveness benchmarks.
As senescence is implicated in tissue repair and the loss of regenerative potential in aging tissues , these findings suggest a source for cardiac rejuvenation.
Assessed biomarkers didn't differ between liver recipients with and without fractures.
Assessing both measures is feasible within primary care.
Assessing implicit memory of new associations is a way to distinguish between these viewpoints.
Assessing older adults with the current tests raises concerns because these measures may not be adequately normed for this age group.
Assessing such fall profiles could be helpful to develop new dedicated fall prevention programs in the elderly.
Assessing their perceptions of the care environment they work in , therefore , becomes a key issue in targeting policy and programs.
Assessing vitamin D nutritional status in adults aged ≥ @number@ years would allow correcting hypovitaminosis D and improve muscle function and strength.
Assessment and intervention of sleep disturbances are warranted and may improve QoL.
Assessment and treatment of activity restriction may be particularly helpful in preventing depression.
Assessment for screening tools takes a few minutes.
Assessment included baseline self-report UI and annual structured exam which assessed parkinsonian signs , motor performances , cognitive function , and self-report disabilities.
Assessment of aesthetic results included the skin hydration , image analysis of nasolabial folds ( 3D ) , and photographic documentation.
Assessment of atrophy helps to distinguish clinically and cognitively deteriorating patients and predicts those who will have a less-favorable clinical outcome over the long term.
Assessment of both measures with transcranial magnetic stimulation ( TMS ) yields information which cannot be obtained with traditional peripheral nerve stimulation.
Assessment of CAP dysfunction in people with ARHI might , therefore , aid identification of older individuals with increased risk of MCI and AD.
Assessment of cognitive functioning is an important component of telephone surveys of health.
Assessment of depressive PD features should also be especially included in the assessment of later-life suicidal risk.
Assessment of diet of individuals living at homes was based on self-reported data from one-day dietary recall.
Assessment of diet of individuals living in nursing homes was based on one-day menu from nursing homes accompanied by information about snacking between meals.
Assessment of fatigability in well-elderly examinations may help identify threats to independent functioning earlier in the decline process.
Assessment of glomeruli revealed that SS-31 reduced senescence ( p16 , ) and increased the density of parietal epithelial cells.
Assessment of oral hard tissues can be of great help in determining the age of an individual.
Assessment of physical limitation was undertaken @number@ years later.
Assessment of pre-pregnancy drinking provides additional information regarding potential prenatal alcohol exposure and its implications for child neurodevelopment.
Assessment of renal function must be considered part of this process.
Assessment of SPV in standing can be done with reliable results.
Assessment of the origin of sleep complaints must consider primary and secondary insomnia , and the existence of associated depression.
Assessment of toxic effects is mandatory before market placement of pharmaceutical and cosmetic products.
Assessments included body mass index ( BMI ) , body composition and ability to perform sport activities.
Assessments included program characteristics , program preparation , and perceived benefits and difficulties.
Assessments included the Chinese version of the Pediatric Evaluation of Disability Inventory and the Parenting Stress Index.
Assessments of cognition , particularly the executive functions , and functional mobility should therefore be an integral part of every comprehensive geriatric assessment.
Assessments of depressive symptoms and perceptual speed were completed by @number@ nondemented older adults at baseline , and after @number@ @number@ @number@ and @number@ years.
Assessments of human Achilles tendon mechanical properties have received great interest.
Assessments of inattention and altered consciousness , markers for delirium , were analyzed to determine if they were also associated with falls.
Assessments using several motor constructs may more accurately identify people at the highest risk of adverse health consequences in old age.
Assessments , using the 5-point scale , occurred at @number@ posttreatment visits over @number@ months.
Assessments were carried out on two occasions ( visit @number@ and visit @number@ ) separated by an interval of @number@ years and @number@ months.
Assessments were completed pre- and post-intervention and at 1-year follow-up.
Assessments were conducted at an 18-month interval.
Assessments were conducted at baseline , @number@ weeks , and @number@ weeks.
Assessments were performed using the Iowa Oral Performance Instrument.
Assessment tools are needed that will enable health care professionals to perceive patients as whole persons , with strengths as well as problems.
Assessment using validated criteria altered classifications for @percent@ of @number@ database entries.
Assessment was ascertained at three time point ; baseline , weeks @number@ and @number@
Assessment will be undertaken with participating residents at baseline ( prior to care home randomisation ) and at @number@ @number@ and @number@ months post-randomisation.
As several countries consider increasing the retirement age , further information on this topic is relevant.
As shown by curve-fitting analyses , phase-locking index and evoked amplitudes were diminishing with age in the linear manner.
As shown by many study groups these days , such driver mutations are acquired in a gene-specific fashion.
Assigned clinical risk levels were compared with the ScoliScore risk levels reported by the manufacturer's scoring algorithm.
Assigning a morphometric age to potential liver transplant recipients could improve prediction of postoperative mortality risk.
Assistants were perceived as a focal point for care delivery and conduits for enabling a service to achieve goals within interdisciplinary team structures.
Assisted living ( AL ) increasingly is becoming a site of EOL care and a place where people die.
Assisted reproductive technologies ( ART ) cannot compensate the natural decline in fertility with age.
Assistive products can help people overcome impairments and barriers enabling them to be active , participating and productive members of society.
Assistive technologies for dementia care remain complex.
Assistive technology , such as sensors or home monitors , may help ' aging in place' , but these have not been thoroughly evaluated.
As slope increased , group differences disappeared and HR decreased for all directions of motion.
Associated alleles of both the SNPs , rs1800896 and rs3024498 , were implicated with overexpression of IL10 gene.
Associated conditions , such as osteoporosis , medical comorbidity , and dementia , pose a significant concern and determine optimal treatment.
Associated dark circles were satisfactorily treated in @percent@ of the patients.
Associated degenerative changes were found at almost all affected levels ( 899 / 901 ) .
Associated factors for cognitive decline were identified by the logistic regression model.
Associated factors were evaluated using linear regression.
Associated infective endocarditis ( IE ) was more frequent in the older group ( @percent@ vs. @percent@ , p < 0.001 ) .
Associated transcripts were further analyzed with GOrilla and IPA to determine enriched cellular processes and pathways.
Associated with a high morbidity and mortality and no specific therapeutic treatment , TBI has become a pressing public health and medical problem.
Associated with these changes were biochemical markers of synaptic pathology.
Association analyses were performed using univariable and multivariable stepwise linear regression models , taking family structure into account.
Association analysis in LLFS families identified single-nucleotide polymorphisms ( SNPs ) nominally associated with EEM in the 40-megabase window encompassing the linkage peak.
Association between Alzheimer disease and genetic variants and genes was measured using logistic regression and sequence kernel association test-optimal gene tests , respectively.
Association between blood serum ferritin levels and nutritional status determined by Body Mass Index was evaluated.
Association between DISH and Cobb angle was analyzed using linear regression.
Association between geriatric conditions and WBC has been scarcely studied.
Association between hypertriglyceridemia and cardiovascular ( CV ) disease is still controversial.
Association between LOS and changes in SGA or weight loss ≥5% was tested using multivariate Cox PH approach.
Association between QoL decline and baseline characteristics including cardiac and geriatric factors was analysed by logistic regression models.
Association between sarcopenia and age , gender , BMI and lean / fat mass ratio was estimated by logistic regression models.
Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy ( FA ) maps.
Association between vaccination and covariates was evaluated by means of prevalence ratios estimated by Poisson regression models.
Association in this gene was replicated in an independent sample consisting of three cohorts.
Association of changes in testosterone levels with changes in QTcF was analyzed in men assigned to the testosterone group of each trial.
Association of extravascular ICAM-1 to GFAP-positive astrocytes was investigated by double-labeling immunofluorescence.
Association of MCR and MCI syndromes is characterized by a worse cognitive performance.
Association of memory risk loci with gene expression in @number@ human hippocampus samples showed cis-associations with WDR48 and CLDN5 , both related to ubiquitin metabolism.
Association of plasma tau with genetic polymorphisms was performed with a linear regression model.
Association of purpose in life with cerebral infarcts was examined in ordinal logistic regression models using a semiquantitative outcome.
Association of these factors with metabolic changes predisposes the older people to suffer drug interactions and adverse drug events.
Associations across cognitive domains were weaker for obesity defined by BMI than for WC.
Associations are presented as odds ratio and @percent@ confidence intervals.
Associations between 25-hydroxyvitamin D and skin aging features were tested by multivariable linear regression.
Associations between adolescent conduct and emotional problems and future memory were of negligible magnitude.
Associations between anthropometric indicators ( measured in 1995-1996 ) and HA were assessed using robust-error-variance Poisson regression.
Associations between asthma history at baseline ( diagnosis before @number@ n = 5311 ) and job type at baseline were evaluated by multinomial logistic regression.
Associations between baseline characteristics and outcomes for the two groups were analyzed by logistic regression.
Associations between body image and physical / mental health were also shown.
Associations between brain volume change , changes in lesion volume and disease duration were examined in pre-specified meta-regression models.
Associations between calibrated protein intake and each of the physical function measures were assessed using generalized estimating equations.
Associations between cataract risk and intakes of selected nutrients and foods generally reflected the strong association with diet group.
Associations between changes in IGF-I or II and body composition outcomes were examined using conditional change linear regression models.
Associations between childhood SEP and outcomes were partly explained by preadulthood weight gain and adult SEP.
Associations between cognitive performance and metabolic syndrome were explored using linear regression.
Associations between comorbidity and estimates of predicted mortality by regression analysis were assessed.
Associations between compliance and changes of nutritional parameters and residents ' characteristics were analysed.
Associations between copper to zinc ratio ( CZr ) and mortality have suggested CZr as a biomarker of aging.
Associations between cortical mean diffusivity ( MD ) and cognitive function were tested using voxel-based regression analysis.
Associations between cortisol , childhood cognition , educational attainment and cognitive function in midlife were tested using linear regression and structural equation modelling approaches.
Associations between CRP categories and lifestyle factors were investigated by using logistic regression.
Associations between CYP11A1 polymorphisms ( rs2279357 , rs2073475 ) and risk of AD were detected in women but not men.
Associations between dementia disorders and HF types were assessed with multinomial logistic regression and survival was investigated with Kaplan-Meier analysis and multivariable Cox regression.
Associations between diabetes and sleep apnea are supported by both epidemiologic and clinical sleep apnea studies.
Associations between disc characteristics , demographic variables , and self-reported glaucoma were explored.
Associations between dry eye and risk factors were analyzed using logistic regression.
Associations between DTI parameters and age , WM injury and clinical factors were analysed.
Associations between FAI and cardiometabolic features were the strongest in PCOS women , even after adjustment for BMI.
Associations between frailty and physical-functional fitness ( PFF ) indicators in frail women over @number@ years of age remain largely unexplored.
Associations between GMV and diabetes complications were not significant.
Associations between goal adjustment and probable depression appeared to be explained by conscientiousness and optimism.
Associations between hippocampal volumes and measures of episodic learning and memory were examined.
Associations between hormone variables and rates of change in urologic outcomes were assessed with linear regression models.
Associations between increased amyloid pathology and cholinergic atrophy have been described in autopsy studies.
Associations between latent profiles and disease outcomes an average of @number@ years later were evaluated with multinomial regression models.
Associations between lifetime and latest prediagnostic leisure time physical activity and overall , CRC-specific , recurrence-free and disease-free survival were evaluated with Cox regression.
Associations between lipid levels and DNA methylation beta values were examined using linear mixed-effect models.
Associations between low birth weight and cardiovascular disease , including hypertension , have also been widely reported.
Associations between LSC score by quartiles and risk of mortality were examined prospectively using Cox's proportional hazard regression models.
Associations between maximal step-up height and other variables were examined using univariate and multivariate methods.
Associations between measures of static and dynamic postural control were found only under the single-task condition in the elderly.
Associations between memory scores and everyday functioning outcomes remained significant across follow-up intervals spanning @number@ years.
Associations between midlife adiposity and cognitive functioning were estimated through covariance analyses.
Associations between MoCA-J scores and occlusal force were investigated via bivariate and multivariate analyses.
Associations between mtDNA C5178A and A10398G polymorphisms with longevity in the centenarian group with mtDNA genotype frequencies 5178A and 10398G were @percent@ and @percent@.
Associations between neuropathological lesions and cognitive impairment were investigated using ordinal logistic regression.
Associations between nutritional status or experiencing a hospital fall and length of stay were also examined.
Associations between obesity and 30-day mortality or long-term risk of death were analyzed.
Associations between PA and other neuroimaging markers were not significant.
Associations between pain and MD were not significant , and MD did not modify the association between pain and gait speed.
Associations between patient characteristics and treatment factors were examined using logistic regression.
Associations between PfS , SI , and SH were examined by logistic regression analysis.
Associations between plasma Aβ and mortality were assessed with the Cox regression model with delayed entry including various potential confounding factors and testing possible mediators.
Associations between plasma concentrations of lipids and cognitive function were investigated for each group.
Associations between polymorphic loci , genotypes , and longevity were analyzed.
Associations between postmenopausal hormone therapy ( HT ) and cognitive decline may depend on apolipoprotein E ( APOE ) status or timing of initiation.
Associations between risk factors and low muscle mass were analysed using logistic regression.
Associations between RTEC consumption , dietary patterns , and cognitive function deserve further study.
Associations between sleep duration during the previous night and morning affect differed depending on the participants ' age.
Associations between sleep quality and memory , and sleep duration and memory were present in the ApoE-ε4 non-carriers.
Associations between SNCA mutations and other Lewy body disorders , such as dementia with Lewy bodies and multiple system atrophy , are also mentioned.
Associations between social support and age-related cognitive decline vary across different relationship types for men and women.
Associations between socio-ecological factors and OLE were assessed with Pearson correlation coefficients and three regression models.
Associations between socioeconomic indicators and SPBC ( @number@ ) were assessed using Pearson's correlation coefficients and multiple regression models.
Associations between specific cognitive domains and BFCS volumes were less pronounced.
Associations between specific red meat subtypes and risk of colorectal cancer ( CRC ) have been investigated in a number of epidemiological studies.
Associations between subjective neighborhood context in childhood versus adulthood were moderate and stronger for residentially-stable populations.
Associations between telomeres , body composition , and physical performance were also examined.
Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed.
Associations between the inflammatory markers and age , sex , and BMI were evaluated first using univariate linear regression analyses.
Associations between these barriers and selected patient characteristics collected at admission or throughout the hospital stay and site characteristics were determined using bivariate analyses.
Associations between these exposures and measured BMI and grip strength were evaluated using linear regression.
Associations between viral load and demographic , obstetrical , HCV risk factors , and interleukin-28B gene ( IL28B ) polymorphism ( rs12979860 ) were assessed.
Associations between visual and cognitive function were explored using general linear models and structural equation modelling.
Associations by type of alcohol consumed ( wine , beer and liquor ) were also investigated.
Associations did not differ between individuals with and without diabetes.
Associations did not differ noteworthy between verbal and non-verbal IQ.
Associations for depression were generally similar to those for the full symptom spectrum.
Associations for nonagenarians and octogenarians were parallel , but weaker.
Associations have been reported between AMD and hypertension , cardiovascular disease , cerebrovascular disease , dyslipidaemia , chronic kidney disease and neurodegenerative disorders.
Associations linking these five variables to HAI were not significantly changed by adjusting for flow cytometry T-cell subset values.
Associations of dietary variety with the outcome measures were examined by logistic regression analysis adjusted for potential confounders.
Associations of job demands and control variables with work ability were more prominent.
Associations of kidney function with muscle composition and longitudinal measures of physical performance are unknown.
Associations of MetS with 19-year all-cause mortality were assessed using Cox proportional hazard models.
Associations of micronutrient intake and homocysteine with LINE-1 and Alu methylation were examined using linear regression.
Associations of multiple air pollutants with pterygium or pterygium recurrence after surgery were examined using multivariate logistic models , after adjusting for several covariates.
Associations of neurodegenerative abnormalities with cerebrovascular disease and cognitive performance indicate that neurodegenerative pathology can emerge through non-Aβ pathways within regions most affected by AD.
Associations of risk factors and failure were similar independent of sling type ( retropubic or transobturator ) .
Associations of SB , BST , and MVPA with physical function were examined , adjusting for demographic attributes , physical independence , and medical status.
Associations of stiffness and blood pressure with physical function scores scaled to SD of @number@ were compared.
Associations of stiffness with functional limitation were robust to multiple adjustment , including pulse pressure and chronic disease.
Associations of task performance and cortical thickness were assessed with cortical-surface-based analyses.
Associations of the locus with expression of ZCCHC14 and DNA methylation suggest the locus acts through changes to regulatory elements.
Associations of the ε4 allele with study outcomes remained significant even after accounting for several potential confounders including vascular and cognitive status.
Associations of urine PIIINP with cardiovascular disease , heart failure , and death were evaluated as secondary end points.
Associations persisted independently of age , presence of cardiovascular risk factors and ApoE gene status.
Associations remained after adjustment for covariates.
Associations remained consistent across time.
Associations remained independent of other variables , although they were attenuated after adjustment for diabetes.
Associations tended to be weaker in the oldest age groups.
Association studies with a case-control design are the time-honored approach to identifying risk factors.
Associations varied somewhat depending on the SEP measure and subjective health and well-being outcome used.
Associations were adjusted for gender , seat track position , vehicle type , vehicle weight , intrusion , and delta-v.
Associations were adjusted for relevant confounders.
Associations were adjusted for relevant covariates ( demographics , memory performance , physical health , mental health , personality traits ) .
Associations were also found between lower fluid intelligence , processing speed , and general cognitive functioning , and agreeing with sexuality no longer being important.
Associations were also investigated between differences in Barthel ADL Index and GDS-15 scores , and in Barthel ADL Index and PGCMS scores.
Associations were analysed using multivariable linear regression.
Associations were analyzed statistically using hierarchical multivariable regression.
Associations were analyzed using Cox proportional hazards regression adjusted for covariates.
Associations were assessed through Cox proportional hazard regression adjusting for several factors.
Associations were assessed using logistic regression and Cox proportional hazards regression.
Associations were assessed using multiple logistic regression.
Associations were assessed with logistic regression models.
Associations were attenuated but maintained after adjusting for other vascular risk factors or for inflammatory markers.
Associations were attenuated but remained significant after controlling for dietary quality ( β = @number@ P = @number@ ) .
Associations were attenuated in subdistribution models ( aHR = @number@ @percent@ CI = @number@ @date@ ) but remained statistically significant.
Associations were calculated between each class of benzodiazepine and eight neuropsychological measures , using multiple regression analysis and controlling for demographic variables.
Associations were estimated between HRQL and exposures in exposure-specific and combined exposure models ( any syndrome , any complication , or hypoglycemia ) .
Associations were evaluated using Cox regression.
Associations were examined using multivariate linear regression for the outcome of log-transformed telomere length.
Associations were examined using region-of-interest ( ROI ) and voxel-based approaches with reference to cytoarchitectonic mappings of the cholinergic BF nuclei.
Associations were examined using survey-based multivariable linear regression for log-transformed LTL.
Associations were explored using the multiplicative logistic model.
Associations were independent of age , sex , demographic factors , and baseline mental and physical health.
Associations were investigated by regression analyses adjusted for age , sex , cognitive impairment , CRP , and VitalPAC Modified Early Warning Score.
Associations were investigated using prevalence ratios and Poisson regressions.
Associations were largely unaltered by control for covariates.
Associations were localized in frontal and temporal areas.
Associations were no longer significant when both groups were analyzed together.
Associations were not altered after adjustment for baseline and year @number@ BP.
Associations were predominantly found in studies analyzing the association cross-sectionally , in a time-varying manner or across short follow-up ( ≤2 years ) .
Associations were rather similar in gender-stratified analyses.
Associations were similar for poor performance.
Associations were similar in the subgroup with neuroimaging before and after adjustment for regional gray matter volume.
Associations were stronger for HLPA than for LLPA.
Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division.
Associations were strongest when evaluating 5-year moving averages of BC exposure.
Associations were studied using Cox proportional hazards analysis.
Associations were tested by linear and logistic regression analyses and adjusted for potential confounders.
Associations were tested using multivariable restricted cubic spline functions and stratified linear regression analysis.
Associations were weaker when they were analyzed as the total 24-h production.
Associations with age were clearly weaker for Pfirrmann grade than for SpIn.
Associations with all-cause mortality , unplanned hospitalization and intensive care unit admission were assessed using Kaplan-Meier curves and Cox regression analyses.
Associations with aspiration and illness severity differed by country.
Associations with dementia and imaging measures validate subgroups of older adults identified with GMM based on their memory trajectories.
Associations with diseases should be the subject of further investigation.
Associations with four health outcomes were examined , namely ADL limitation , self-rated health , depression , and a quality of life index.
Associations with higher odds of peripheral neuropathy included older patient age and current nART use.
Associations with higher odds of peripheral neuropathy while on nART included older patient age and current protease inhibitor use.
Associations with higher odds of SPN included older patient age , nART use , and history of diabetes mellitus.
Associations with higher odds of SPN while on nART included older patient age , history of diabetes , taller height , and protease inhibitor use.
Associations with LOS were examined among @number@ potential predictor variables using bivariate correlations.
Associations with lower odds of recovery after nART discontinuation included older patient age.
Associations with objective variables were strongest for neighborhood disorder ( rhos = .40 ) , as opposed to with social control or victimization.
Associations with smoking , asthma and rhinitis confirmed previous findings in younger populations.
Associations with socialization were not statistically significant at either follow-up.
Association tests of individual SNPs showed that Super-Seniors were less likely than controls to carry an APOEε4 allele or a haptoglobin HP2 allele.
Association to PD at SNCA was replicated in the Japanese GWAS , confirming this as a major risk locus across populations.
Association was also observed in the London cohort but in the opposite direction.
Association with particular aging-related diseases awaits replication and independent validation.
Association with rs11046966 was not replicated in the International COPD Genetics Network.
Associative memory develops into adulthood and critically depends on the hippocampus.
Associative memory is essential to everyday activities , such as the binding of faces and corresponding names to form single bits of information.
Associative memory refers to remembering the association between two items , such as a face and a name.
As society ages , aging medical problems such as organ damage or failure among senior citizens increases , raising the demand for organ repair technologies.
As specifically younger women tended to be impacted by FoR , it is crucial to be particularly attentive to specific needs of younger survivors.
ASSRs were also found to be enhanced within this time range but only for adults.
As stimulus demand increases , visual and auditory cortex do not show increases in activity in older compared to younger people.
As such , a crushing wave of cardiometabolic disease burden now faces our society.
As such , a different approach is required to care for the elderly trauma patient.
As such , age-associated reductions in anterior HC volume may contribute to the context memory deficits observed in older adults.
As such , bottlenose dolphins may serve as a useful comparative model for aging in humans.
As such , calf circumference is a valuable tool for guiding public health policy and clinical decisions.
As such , chronic inflammation may represent an important therapeutic target in prostate cancer.
As such , clinicians should continue to consider the formulations to be equipotent until such time that compelling clinical evidence to the contrary becomes available.
As such , considerable effort has been placed on initiatives that aid the early detection of cancer , as this may improve patient survival outcome.
As such , FGF23 is involved in phosphate homeostasis and its serum levels increase along with the progression of CKD.
As such , genome maintenance and its phenotypic sequelae provide yet another example of antagonistic pleiotropy in aging and longevity.
As such , HBV vaccination is recommended in HCV-infected individuals.
As such , home healthcare clinicians face increased pressure to find resources and continuing support for patients.
As such , HSPs have the potential to function as an important defense system against the development of insulin resistance and type @number@ diabetes.
As such , identification of a NF is important.
As such , it has intimate links to related compensatory and neuroprotective concepts , as well as to the related notion of brain reserve.
As such , it is advantageous to better understand the physiopathological mechanisms of these age-related inner ear diseases.
As such , it is important to target adaptive skills , and the EF problems that may contribute to them , in youth with HFASD.
As such , it is impossible to understand the mechanisms that underlie this association.
As such , leucine has received considerable attention as a potential pharmaconutrient for the treatment of numerous muscle wasting conditions.
As such , loneliness describes the extent to which someone's needs are not being met and thus provides a subjective assessment of support quality.
As such , maintenance of chromatin structure is an integral component to deter premature aging.
As such , many people spend greater portions of their lives as sexually active individuals.
As such , medical thoracoscopy is ideally positioned as a valuable tool in the diagnosis of unexplained exudative pleural effusions.
As such , multiple biological factors must be considered when assessing SCD in clinically healthy older adults.
As such , organizations should make every effort to retain these individuals and implement efforts for their continued contribution to the healthcare industry.
As such , parental life span is an important phenotype that may uncover genes that affect longevity.
As such , processes should be carried out in an identical fashion for all patients , regardless of how vulnerable or complex they are.
As such , promoting healthier lifestyles among the socioeconomically disadvantaged older adults should help to reduce later life health inequalities.
As such , PSCs represent an unprecedented unlimited ex vivo cell source.
As such , rural nurses are an invaluable resource to the health and wellbeing of rural populations.
As such , senility can present itself as a barrier for everyday activities.
As such , Sirt1 appears to be of particular importance in maintaining endothelial functions and delaying vascular aging.
As such , stem cells maintain tissue homeostasis throughout the life of a multicellular organism.
As such , targeting of HDACs seems to be a promising therapeutic strategy.
As such , the adequacy of nutrition before birth and in the early formative years may have long-term consequences.
As such , the challenge of treating joint pain and degeneration is temporally and spatially complicated.
As such , the definition describes an equal responsibility for employee and employer to maintain the employee's ability to work.
As such , the expanded prion paradigm could conceptually unify fundamental and translational investigations of these disorders.
As such , the main component to treatment is reversing the underlying venous hypertension and pro-inflammatory milieu using compression treatment along with various adjuvant therapies.
As such , there are cases in which BOLD signals might be dissociated from neural activity , leading to misleading results.
As such , there is concern regarding use of autologous adult stem cell therapy in older patients.
As such , these results may be a potential therapeutic strategy for halting the progression of PD.
As such , they have garnered much interest and have been widely studied in aging and age-related neurodegeneration.
As such , they measure temporal foresight and the ability to delay gratification , functions that develop slowly into adulthood.
As such , this nematode system has demonstrated its value in predicting functional modifiers of human neurodegenerative disorders.
As such , this procedure offers an effective alternative to current approaches , adding to the toolbox of techniques available to forensic and other interviewers.
Assuming tHFS-induced plastic reorganization in somatosensory cortex our results give further evidence to the notion of an interrelation between sensory and motor performance.
Assuming those 65 + living in institutions as unsuccessful agers , then the prevalence of SA was @percent@ among Canadian seniors aged 65 + .
Assumptions frequently associated with patient decision making were not consistent with the empirical literature.
Assumptions were derived from published literature where available and validated using national surveillance data for incidence of NAFLD-related HCC.
Assumptions were verified in one-way and probabilistic sensitivity analyses , which confirmed the robustness of the model.
A stable HCECs cell line ( TERT-HCECs ) that expressed TERT was established.
A staged approach to recruitment was adopted involving separate meetings with staff , residents and relatives.
A staging algorithm based on the Precaution Adoption Process Model measured behavior change toward increased and sustained driving self-regulation.
As Taiwan has become the fastest aging country in the world , developing elderly-friendly health care services is of great importance.
A standard assessment instrument was used most frequently by PhDs ( @percent@ ) , but this generally assessed cognitive status rather than problem behaviors.
A standard intertrial design was implemented whereby participants studied word lists over several study-test trials.
A standardised lifestyle activity questionnaire exploring activities from four categories ( intellectual , physical , social and recreational ) was used to measure the pattern.
A standardised method would enable more consistent measurement of grip strength and better assessment of sarcopenia.
A standardized method for assessing the physical fitness of elderly adults has not yet been established.
A standardized mortality ratio ( SMR ) was calculated , as well as average age at death.
A standardized questionnaire was applied at home to collect data about pain , sociodemographic characteristics and abdominal circumference measurement.
A standardized questionnaire with detailed instructions was sent to all eligible families.
A standardized , reliable and comprehensive label for consumers and professionals is currently lacking.
A standardized schedule for winding down would have advantages for physicians , their department , and their patients.
A standardized skills checklist assessed proficiency in fall risk screening administration immediate posttraining and at onsite community screenings.
A standardized test meal ( STM ) was administered before and at @number@ @number@ @number@ @number@ @number@ and @number@ months.
A standard statistical comparison and multiple regression analysis using the stepwise method were performed.
A State Space Grid analysis showed that the effect of R6 was different for the Yin deficiency subjects and the Qi deficiency subjects.
A state-sponsored evaluation of aging in place ( AIP ) as an alternative to assisted living and nursing home has been underway in Missouri.
A static balance test for SI was performed at the initial meeting and @number@ weeks after the assigned insoles were worn for each participant.
A statistical evaluation was performed.
A statistically significant feature profile was established using a four-phase model of sit-stand-sit movements and two waveform features.
A statistically significant impact on function was found in one patient.
A statistically significant increase in the epidermis and papillary dermis thickness was seen after PRGF treatment ( p < @number@ ) .
A statistically significant increase was found on SCM thickness in the CF group.
A statistically significant increase was observed after @number@ and @number@ weeks for dermal distance and dermal intensity , respectively ( P < 0.05 ) .
A statistically significant negative association between levator function and blepharoptosis was found.
A statistically significant negative correlation between the sample fracture load and cadaver age was found.
As tau transgenic mice accumulated insoluble tau in the brain , brain soluble and interstitial fluid tau decreased.
Astaxanthin ( AST ) is a carotenoid pigment which possesses potent antioxidative , anti-inflammatory , and neuroprotective properties.
Astaxanthin ( AXT ) is a carotenoid with multiple health benefits.
Asteatotic and perineal irritant dermatitis are the most important subtypes of irritant contact dermatitis in the elderly.
A steeper decline in affect balance was evident over a time-to-death metric compared with chronological age.
A stem cell transfer system could be an attractive and effective immunologic intervention strategy to reverse mucosal immunosenescence.
A stepped wedge design was used to trial the CSNAT intervention in three bases of Silver Chain Hospice Care in Western Australia , 2012-14.
A stepwise discriminant procedure determined which principal components ( PCs ) were most successful in differentiating the two groups.
A stepwise increase in stroke risk was apparent with increasing numbers of these cognitive and imaging markers.
A stepwise logistic model was built to predict TBAD risk.
A stepwise logistic regression showed that education levels may play a role in various intervention methods.
A stepwise regression analysis was used which dropped variables from analysis if they did not contribute sufficient explanatory power.
As the ACC is involved in processing of fear and anxiety , our results indicate that these processing are related to vulnerability for PTSD symptoms.
As the accumulation of AGEs may reflect the metabolic state and receptor signaling , we evaluated the potential prognostic and predictive value of this biomarker.
As the aged population continues to increase dramatically , so too will the financial strains associated with the long term care of the elderly population.
As the aged population increases worldwide , it is essential to identify the specific features of this disease in the elderly population.
As the ageing population increases , the health of the elderly also becomes of growing concern.
As the age of the population rapidly increases , a sheer increase in the incidence of these diseases is expected.
As the aging population increases , Alzheimer's disease is becoming a major concern of Public Health.
As the aging population in our society continues to grow , new technologies and procedures promising a more youthful appearance are continuously sought.
As the aging population is increasing and unhealthy life styles persist in our country , there will be an unnegligible cancer burden in China.
As the average lifespan of humans continues to increase , improvement in the quality of life for elderly people is important.
As the baby boom generation ages , policymakers are expressing concerns about rising costs , variation in home healthcare service use , and program integrity.
As the best model to analyse the role of prelamin A in normal ageing , we used cells from centenarian subjects.
As the biological mechanism is uncertain and this study size is limited , our results should be interpreted as hypothesis generating.
As the body ages , it undergoes a multitude of changes.
As the calcification becomes more extensive it might be mistaken for an intracardiac tumour.
As the cohort of PLWH has aged , so the spectrum and burden of age-associated noncommunicable comorbidities ( AANCCs ) in the cohort has increased.
As the connective tissue is interspersed with mechanoreceptors that are sensitive to pressure induced externally , affected structures are accessible for prophylactic and therapeutic intervention.
As the current generation of polysaccharide vaccines do not provide sufficient protection for elderly , new vaccination strategies are urgently needed.
As the data were not normally distributed , the Mann-Whitney U-test was employed to assess the statistical validity of the difference observed.
As the demographic shifts to a more aged population , a growing number of postmenopausal women will be afflicted with osteoporosis.
As the demographic structure changes , the disease structure changes , and therefore the medical care demand changes.
As the described protocol is very straightforward and robust it may be suitable for many pairs of interacting proteins.
As the developing world becomes more urbanised and westernised , disorders that are now rare in the developing world will probably become much more common.
As the dominant component of the human skeleton , cortical bone plays a key role in protecting bones from fracture.
As the European population ages , surgeons are regularly faced with octogenarians with resectable early stage non-small cell lung cancer ( NSCLC ) .
As the EVA construct is advancing , new features appear as interesting to better translate it into clinical practice.
As the first non-hormonal alternative to estrogen-based products for this indication , the approval of ospemifene represents a significant milestone in postmenopausal women's health.
As the French population is aging , a growing number of elderly patients with symptomatic severe aortic stenosis are going to require therapeutic management.
As the French population is aging , a growing number of elderly patients with symptomatic severe aortic stenosis are going to require therapeutic management.
As the general population is aging and the rate of CKD rising , updating knowledge on managing these patients is critical for care providers.
As the general population's age increases , it will be important to individualize prediction models and therapeutic targets to this high risk cohort.
As the global population ages , older decision makers will be required to take greater responsibility for their own physical , psychological and financial well-being.
As the global population ages , the number of older people ( ≥65 years ) living with IBD is expected to increase.
As the growth of the elderly population accelerates in Brazil , VL poses a greater challenge to public health.
As the HIV epidemic enters its fourth decade ( the second decade of ART ) , research must address evolving factors in HAND pathogenesis.
As the HIV population is aging , a growing impact of cardiovascular events on survival can be expected.
As the hub for many cellular functions , the maintenance of an adequate pool of functional mitochondria is crucial for tissue homeostasis.
As the incidence of death in nursing homes increases with the aging population , the gap in measurement must be addressed.
As the incubation time increases , the size of amorphous aggregates increases and they are incorporated into single-stranded filaments.
As the index of early kidney damage both glomerular filtration rate was calculated and albumin / creatinine ratio in the urine sample was measured.
As the isolation of circulating exosomes is a minimally invasive procedure , this technique opens new possibilities for diagnostic applications.
As the life expectancy of DS persons is rapidly increasing , this decline is becoming a dramatic health problem.
As the mature follicle population is depleted through natural cycling , ovarian failure follows increasing periods of acyclity.
As the medical education community celebrates the 100th anniversary of the seminal Flexner Report , medical education is once again experiencing significant pressure to transform.
As the molecular mechanisms underlying the pathology are largely unknown , this cardiac arrhythmia remains difficult to treat.
As the nocturia definition is complicated there are also other slightly modified definitions.
As the number of healthy behaviors increased , the likelihood of disability decreased.
As the number of older adults continues to rise worldwide , the prevention of physical disability among seniors is an increasingly important public health priority.
As the number of people older than @number@ years in the United States increases , the home care population will increase as well.
As the numbers of frail elderly people increase , so will the burden of incontinence.
As the older adults began to seek value beyond individuals , they gradually expanded their communities beyond geographical and generational boundaries.
As the older adult segment of the population increases , Alzheimer's disease ( AD ) has emerged as a significant public health epidemic.
As the options of prevention of arterial diseases are well known , this will also provide possibilities for extensive prevention of memory diseases.
As the other skeletal muscles , respiratory muscles may also be affected by sarcopenia.
As the perceived needs of caregivers may evolve with the progression of the disease and the dementia transition , their needs should be regularly assessed.
As the permeabilized fiber bundle consumes oxygen , oxygen concentration in the closed chamber declines.
As the population ages , end-of-life care ( EOLC ) costs become an increasingly pressing subject.
As the population ages , increasing attention has become focused on the prevalence of anemia in elderly individuals.
As the population ages in Western countries , the number of people being diagnosed with glioblastoma is expected to increase.
As the population ages , police increasingly serve as first responders to incidents involving older adults in which aging-related health plays a critical role.
As the population ages , successive cohorts of older adults will experience depressive disorders.
As the population ages , the economic and societal impacts of neurodegenerative and neuropsychiatric disorders are expected to rise sharply.
As the population continues to age , the specialized needs of older adult patients warrant the close attention of the critical care nurse.
As the population continues to age , we will continue to encounter issues involving aging and the elderly.
As the population of older Latinos in the U.S. increases , availability of culturally adapted geriatric psychiatry services is becoming a growing concern.
As the population of the Western world ages , the number of major surgical procedures performed in the elderly population will by necessity increase.
As the population steadily ages , dementia , in all its forms , remains a great societal challenge.
As the precise mechanisms underlying CSC aging remain unclear , the use of therapeutic strategies for elderly patients with heart failure is severely delayed.
As the pre-dementia phase of Alzheimer disease , mild cognitive impairment ( MCI ) involves the onset and development of cognitive impairments.
As the process of aging and patterns of sleep change over time , longitudinal research designs are recommended for future studies.
As the proportion of older adults increases , falls will place an increasing demand and cost on the health care system.
As the proportion of older people increases , so will chronic disease incidence and the proportion of the population living with disability.
As there are no deaths directly attributed to OA , YLDs equate disability-adjusted life years ( DALYs ) .
As there are various underlying conditions , ranging from musculoskeletal disorders to acute coronary syndrome ( ACS ) , thorough clinical diagnostics are warranted.
As the relative work load may increase and recovery processes slow down among aging employees , fatigue may occur unless work arrangements are well-designed.
As there may be regional and national variations in practice , each centre should generate such data for use locally.
As the result , it was confirmed that swallowing activity can be quantified by the detected MMG signal from different region of neck.
As the results , all patients were examined by internal medicine doctors at the time of admission.
As the saline component absorbs , the filling material is distributed more evenly in the temple than with undiluted filler.
As the sample is a convenience sample of ( relatively ) healthy older adults , generalizability of these results is limited.
As these age-related changes diminish cognitive reserve , the decline in the related cognitive domains emerges.
As these associations have emerged since age @number@ it suggests that LTPA across adulthood may prevent decline in grip strength in early old age.
As these children age into adulthood , it is imperative to continue their survivor-focused care.
As these filters absorb part of the visible spectrum , they may affect visual function.
As these functions do not represent any observable quantities , they have to be identified from the observations.
As these individuals age , comorbid cerebrovascular disease will likely impact cognitive function.
As these investigations move forward , bridging the divide between approaches addressing elderly individuals versus persons with disabilities will be critical.
As the selection of a medical modality is not completely independent , environmental and sociocultural contexts of ecological validity are desired.
As these variants were not found in Single Nucleotide Polymorphism databases and were absent from @number@ controls they could be new SS18L1 mutations causing ALS.
As these women live longer and age , their social support needs may increase.
As the size of the elderly population increases , so do the challenges of and barriers to high-quality , affordable health care.
As the technology for quantitative hepcidin analysis improves , hepcidin's role in various disease states is also being revealed.
As the US population ages , more older adults will face transportation and mobility challenges.
As the US population ages , trauma systems face new challenges in addition to the long-standing problem of access.
As the variability may reflect impaired homeostatic regulation , we assessed albumin variability over time in chronic hemodialysis ( HD ) patients.
As the world ages , these costs are increasing rapidly , while health systems face finite budgets.
As the world population is aging these two diseases are becoming a significant public health problem worldwide.
As the world prepares for an increasingly aging population with chronic debilitating diseases , the demand for home healthcare services is increasing.
As the world's population ages , elderly people are becoming an increasingly important group that merits special attention with regard to health and social issues.
As the world's population ages , gender-unbiased health services for this growing population , with age-related chronic illnesses , will be essential.
As the world's population ages , hip fractures pose a significant health care problem.
As they age , those with SMI experience increased physical illnesses , functional impairment , cognitive deficits , and social disability.
As they gradually became more dependent on medical care , many experienced that they were not given the desired help , which confirmed their distrust.
As they grow older , the risk of this and similar types of carcinoma decreases and the nature of the periodic check-ups changes.
As the younger cohorts age into Medicare and develop more conditions , it will be important to see whether these tentative findings strengthen.
As this area frame the look , it should be taken into consideration during the clinical examination as well as the facial and cervical stages.
As this is the underlying promise of biomedical research-delivering advances to public health to improve the quality of life-such strategic initiatives are paramount.
As this large surgical procedure induces muscle protein loss , a preserved anabolic response to nutrition is warranted for optimal recovery.
As this pathway is significant in the development of epithelial ovarian cancer ( EOC ) we studied klotho expression and activity in this tumor.
As this population grows , the number of ICU admissions is expected to increase.
As this population increases prison authorities will need to adjust the custody process to accommodate increasing mental and physical frailty.
As this population segment grows , pressure will increase for policy and business solutions to existing medical care challenges.
As this success depends on the older patient's characteristics at the time of admission to CR , we attempted to determine the most important influences.
As this value is specific for gold , it confirms the presence of the metal in the patient's skin.
Asthma and chronic obstructive pulmonary disease ( COPD ) are thought to share a genetic background ( \ "Dutch hypothesis \ " ) .
Asthma and COPD remain two diseases of the respiratory tract with unmet medical needs.
Asthma has been demonstrated to be as common in the elderly as in younger age groups.
Asthma in older patients is not uncommon , and this is a growing population as the average lifespan increases.
Asthma in older people is common and is characterised by underdiagnosis and undertreatment.
Asthma in the elderly ( > 65 yr old ) is common and associated with higher morbidity and mortality than asthma in younger patients.
Asthma in the elderly and younger population are compared.
Asthma is a common condition in the elderly although often confounded with chronic obstructive pulmonary disease ( COPD ) in this population.
Asthma is a disease of all ages.
Asthma is associated with significant morbidity and mortality in the geriatric population.
Asthma is under-diagnosed , and under-treated , in the elderly , further exacerbating these negative consequences.
Asthma symptom control was assessed according to GINA @number@ guidelines.
Asthmatic patients showed significant decreases in CD95 ( p = 0.
Asthmatics presented an increase in CD4 cells ( p < 0.05 ) .
As THR is performed with increasing frequency in aging populations , it is important to know the impact of these problems on the postoperative result.
Astigmatism equal or higher than @number@ D in minus cylinder form was used.
Astigmatism has a large impact on visual perception ; more than @percent@ of people with astigmatism over one diopter wore glasses for distance vision.
Astigmatism was defined as the cylinder power of @number@ diopter ( D ) or more.
Astigmatism was found to have a strong correlation with myopia , although individuals with high hyperopia also had high astigmatism.
As tissue integrity declines , it becomes less capable of supporting and maintaining resident stem cells.
As to exercise intensity , self-evaluated low-to-moderate intensity exercise might be better for the psychological well-being of the elderly.
A story draft was produced using the interview recording and verbatim transcript.
Astragaloside decreased the mRNA level of MMP-1 compared with the UVA irradiation alone , while the TIMP-1 expression increased ( P < 0.05 ) .
Astragaloside IV ( AST ) is one of the major active components extracted from Astragalus membranaceus.
Astragaloside treatment was shown to decrease the level of SA-β-gal compared with the UVA group.
As transcription is dependent on the DNA containing the expanded repeats , it is crucial to understand its structure.
A stratified cluster random sampling method was performed , and @number@ ischemic stroke patients ( over @number@ years of age ) were enrolled.
AS-treated cells exhibit increased calpain activation , and calpain inhibition greatly alleviates the observed toxicity.
As treatment complexity increases the potential grows for non-adherence to medications due to side-effects , drug-disease interactions , costs , and patient confusion about medicines.
As treatments become available and target specific molecular abnormalities , differentiating amongst the various primary dementias early on becomes essential.
As treatments to prevent aging-related diseases simultaneously are desirable , we investigate common backgrounds underling these diseases.
As tremor exhibits non-linear properties , employing both linear and non-linear analyses may help distinguish between the tremor dynamics of aging , PD and ET.
A striking feature of our findings is the relatively low scores on loneliness of older Canadians compared to older adults in other countries.
Astrocyte biology has been examined using molecular , biochemical and structural methods , as well as 3D brain imaging in live animals and humans.
Astrocyte involvement includes mitochondrial damage that either precedes or is accompanied by neuronal damage.
Astrocytes and microglia are the key players in neuroinflammatory responses , by secreting an array of pro- and anti-inflammatory cytokines , anti-oxidant and neurotrophic factors.
Astrocytes are an important participant in maintaining the cerebral ATP budget.
Astrocytes are fundamental for homoeostasis , defence and regeneration of the central nervous system.
Astrocytes are one of the principle cell types in the CNS and the stages associated with their development remain very poorly defined.
Astrocytes are the most abundant glial cells in the central nervous system and are involved in the neuroinflammation.
Astrocytes become activated in Alzheimer's disease ( AD ) , contributing to and reinforcing an inflammatory cascade.
Astrocytes become increasingly filled with glial filaments as TG mice age , and microglial cells almost always contain phagocytic inclusions.
Astrocytes can be activated by numerous factors , including free saturated fatty acids , pathogens , lipopolysaccharide , and oxidative stress.
Astrocytes express a variety of G protein-coupled receptors and might influence cognitive functions , such as learning and memory.
Astrocytes express the S1R , which mediates BDNF release when stimulated with the prototypical S1R agonists 4-PPBP and ( + ) -SKF10047.
Astrocytes have in recent years become the focus of intense experimental interest , yet markers for their definitive identification remain both scarce and imperfect.
Astrocytes secrete growth factors that are both neuroprotective and supportive for the local environment.
Astrocytes with expression of p-tau Ser396 and neurons with co-localization of p-tau Ser396 and ubiquitin were observed.
Astrocytic neuroprotective functions require energy , and therefore require a network of functional mitochondria.
A strong association between the serum trough and urine theophylline concentrations was found ( P < @number@ ) .
A strong correlation between the locations of the nerve fibers and the intensity distribution is confirmed.
A strong correlation between the tibialis anterior and the force response was also detected ( r = 0.80 , p < 0.01 ) .
A strong correlation between total striae numbers and periodicity was also identified in our sample.
A strong correlation in CFS between brainstem GM volume and pulse pressure suggested impaired cerebrovascular autoregulation.
A strong correlation is found between sodium and potassium while calcium and magnesium levels are inversely correlated.
A stronger linearity of SF and β-actin compared with GAPDH and α-tubulin was observed.
A stronger MOC inhibition was observed when measured during the active listening condition for adults which is consistent with past work.
A strong joint action with the surgical team is essential.
A strong positive relationship between fibre size and satellite cell content was detected in trained individuals.
A strong relationship between IGF-1 and thymic ouput was evidenced.
A strong seasonal pattern was observed for major pathogens of acute diarrhea among the elderly.
A Stroop task was performed , and an electroencephalogram ( EEG ) was recorded.
A structural equation model was constructed.
A structural model with latent variables was specified and estimated in Mplus.
A structured approach to measurement is urgently required to fully realise the contribution gait can make to our understanding of neurodegenerative disease.
A structured consultation is key to optimising patient engagement and ensures a tailored approach to understanding and catering to the specific needs of each patient.
A structured focus group with fellows revealed themes of accountability and the importance of interprofessional teamwork in QI.
A structured history , followed by physical examination and additional tests if necessary , can yield clues to factors that may contribute to dizziness.
A structured questionnaire covering the WHO's eight AFC domains was developed to collect information on the perceived neighbourhood environments , SRH and individual characteristics.
A structured questionnaire was administered to @number@ Italian outpatient hypertensive patients ( mean age , @number@.2±14.4 years ) .
A structured questionnaire was administered to obtain clinical information.
A structured questionnaire was used for data collection.
A structured questionnaire was used to collect data of demographics , menopausal status , chronic diseases , reproductive history.
A structured questionnaire was used to collect data regarding the 2-year incidence of EA and its subtypes.
A structured questionnaire was used to collect socio-demographics and care-giving characteristics.
A Student Description Form and the Ageism Attitude Scale ( AAS ) were the data collection instruments used in this study.
A study limitation may be the relatively small sample size.
A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment.
A study on familial Parkinson disease ( PD ) described @number@ variants in the gene TMEM230 ( Chr.
A study questionnaire was also sent out in brown or white envelopes @number@ week after consenting to participate in the trial.
A study was undertaken to examine these features in a cohort of healthy children.
A study with a higher follow-up period demonstrated improvements in albumin , weight and chronic inflammation parameters.
A study with two parts , one qualitative and one quantitative , examined this interface in Norway.
As type @number@ diabetes is frequently diagnosed before the age of @number@ diabetes-related cognitive dysfunction may also occur before the age of @number@
A sub-analysis described oligosaccharides and bacterial composition in greater detail.
A sub-analysis was conducted on those services that provided children food ( n @number@ at baseline and n @number@ at follow-up ) .
A subcoracoid secondary ossification center in the superior glenoid was identified and fused in all by age @number@ and @number@ respectively.
A subdivision of the corpus callosum in both hemispheres revealed that the AD pathology primarily affects the body and splenium of the corpus callosum.
A subgroup also underwent amyloid PET and MRI neuroimaging.
A subgroup analysis from the dabigatran-investigating trial indicated that elderly patients might have a higher risk for extracranial bleeding complications with NOAC than with VKA.
A sub-group analysis was performed on the @number@ subjects with a caregiver.
A subgroup of @number@ ED patients completed the International Index of Erectile Function-5 ( IIEF-5 ) questionnaire.
A subgroup of @number@ men met criteria for AAMI based on baseline subjective memory complaints and objective memory performance.
A subgroup of @number@ participants with very low AD risk was also studied.
A subgroup of patients also underwent measures of these parameters in extracellular and intracellular compartments of PBMCs ( ancillary study ) .
A subgroup of the Older performed cognitive training during BR and supplemented protein and potassium bicarbonate afterwards.
A subgroup of the study population was selected with a reason for exposure of \ error. \ "
A subgroup of vaccine nonresponders were compared to responders and found to have reduced frequencies of memory B cells and antigen-specific antibody-secreting cells after vaccination.
A submaximal-effort tourniquet test was used to provide a standardized degree of conditioning ischemic pain.
A subsample ( n = 10 ) also participated in semi-structured interviews.
A subsample ( n = @number@ ) also participated in semi-structured interviews analysed using the Miles and Huberman analytic method.
A subsample of @number@ respondents aged @number@ years and older were used for this study.
A subsample of USDA Choice ( n = @number@ ) and USDA Select ( n = @number@ ) carcasses was selected.
A subsequent analysis examined whether the high- and low-performing older adults differ in patterns of gain from receiving instruction and practice on a mnemonic strategy.
A subsequent subgroup analysis found that in subjects aged @number@ years and older , the association between hsTnT levels and HCY levels was strengthened.
A subsequent survival analysis availing of Accelerated Failure Time models allowed us to formulate an operative index able to correlate classification variables with survival probability.
A subset ( n = @number@ ) underwent structural MRI.
A subset of Alzheimer's disease ( AD ) occurrence shows autosomal dominant , familial inheritance patterns.
A subset of female carriers also exhibits CeH.
A subset of novel loci was significantly associated with changes in methylation or expression levels of adjacent genes.
A subset of @number@ fish oil patients crossed over to controls in the final @number@ months ( crossover group ) .
A subset of @number@ individuals had fluorodeoxyglucose ( FDG ) PET.
A subset of @number@ participants also underwent magnetic resonance imaging ( MRI ) .
A subset of @number@ participants completed accelerometer assessments during follow-up.
A subset of @number@ participants who underwent ECG recording during resting and paced breathing periods were used for the analysis.
A subset of older adults with high verbal fluency maintained a young-like effect pattern.
A subset of older people is at increased risk of hospitalization and dependency.
A subset of participants also participated in a substudy that included ante-mortem imaging.
A subset of participants ( n = @number@ ) completed the same task during fMRI.
A subset of participants was reassessed @number@ months later.
A subset of patients was subjected to imaging biomarker studies as a part of routine clinical practice.
A subset of @percent@ of participants demonstrated inappropriate intrusion of MMSE Pentagon Copy during another test of visuospatial recall.
A subset of seminiferous tubules with an appearance and distribution compatible with the predicted mutant clones were identified.
A subset of subjects ( n = @number@ ) also underwent the procedures after an intravenous infusion of propranolol.
A subset of subjects was studied longitudinally @number@ and @number@ years after the first scan.
A subset of the mild cognitive impairment ( n = 61 ) and mild AD ( n = 79 ) participants underwent an autopsy.
A subset of the most reliable measures is recommended for measuring walking and balance in clinical settings.
A subset of the participants completed the AMD test multiple times and the AMD test was found to be reliable across repetitions.
A subset of these participants enrolled between @number@ and @number@ had elder abuse reported to social services agencies ( n = @number@ ) .
A subset of these participants were suspected to self-neglect and were reported to a social services agency.
A substantial majority of generalists were either general practitioners or family physicians ; the majority of specialists were neurologists.
A substantial number of brain areas presented some degree of asymmetry.
A substantial part of this historical increase is due to decreases in early life mortality.
A substantial percentage of subjects exhibited folate dietary deficit ( @percent@ ) .
A substantial proportion of clinicians ( @percent@ ) diagnose frailty using more than one instrument.
A substantial proportion of cognitively impaired individuals who took antimuscarinics were simultaneously taking other anticholinergic medications.
A substantial proportion of intercohort variation in testosterone levels is due to assay differences.
A substantial proportion of this risk may be unrecognized because of the current reliance on body mass index in clinical practice.
A subtle decline in psychological health paralleled decline in physical function but did not accelerate it.
A subtype of microglia is defined by the morphological appearance of the cells as rod shaped.
A successful aging index ranging from 0-10 was used.
A successful endoscopic therapeutic approach was possible in one fifth of the patients.
A suggested but untested reason for this improvement in cognitive function over time is higher educational attainment among more recent cohorts.
A suggested decreasing trend in the prevalence of UI was associated with a longer time since cancer diagnosis.
A suggested work-flow for selecting ICV normalization method when investigating gender related differences in regional brain volume is presented.
A suitable acquisition medium for RSSC collection was identified and samples of RSSC were subsequently analysed using gas chromatography-mass spectrometry ( GC-MS ) and gravimetry.
A summary of this project and key findings is included.
As U-models , they have a set of parameters , which are comparable across models in the family , without conversion equations.
A sunscreen is mandatory , and emollients may be prescribed for the dryness and peeling that could occur.
A supporting algorithm distinguishes rib position from epigastrium using the relationship between force and displacement.
A suppression of the bimanual advantage would thus indicate a deficit in sensory reafference.
A surface-based morphometry analysis based on an age- and sex-matched sample of @number@ ALS patients and @number@ healthy control subjects ( HC ) was conducted.
A surge of InhB was noted following the LH surge in 16 / 20 cycles.
A surgical excision was performed with an excellent therapeutic result.
A surrogate approach was exploited to test the significance of the computed quantities.
A survey has been done to determine their demographic features.
A survey instrument assessing ageing-related conditions of the elderly will be also developed.
A survey of student nurses in Grenoble , confirms this view.
A survey was administered to all health / medical students and teachers at The University of Western Australia.
A survey was conducted to identify current practices in France.
A survey was conducted with @number@ Ugandans aged @number@ and older , living with and without HIV.
A survey was mailed to community-dwelling older adults @number@ and older.
A survey was organized to identify current practices in France.
A survival analysis using a Cox proportional hazards model was performed to assess predictors of recurrence.
As US populations become increasing diverse , healthcare professionals are facing a heightened challenge to provide cross-cultural care.
As various potential threats to LS tend to increase with advancing years , patterns of age-related changes in LS among older adults remain inconsistent.
As was seen for cognitive and behavioral dysexecutive impairments , the prevalence of socioemotional impairments varied according to the diagnosis.
As we age , cell senescence can contribute to BBB compromise.
As we age , movements become slower and inconsistent and require more attention.
As we expected variability of relative phase was larger for older participants than for younger ones for both the in-phase and the anti-phase coordination patterns.
As we know , both of them originate from the neural crest , but have distinct characteristics and functions in vitro and in vivo.
As well , a large number of tweets discussed recent research findings related to the prediction and risk management of Alzheimer's disease.
As well as damaging the eyelids and periorbital skin , chronic UV exposure may also affect the conjunctiva and lens.
As well , technological challenges were encountered.
As well , we review developmental and childhood acquired disorders that involve a failure of regulatory homeostasis.
As were the covariates of age and sex , senior activity frequency was significantly related to @number@ or more physical function tests.
A swimming challenge test was performed and showed that swimming capacity and endurance dramatically dropped in older fish groups.
As with all cancers , early diagnosis of bladder cancer significantly improves the efficacy of therapy and increases survival and recurrence-free survival rates.
As with all surgical procedures , facelift is associated with certain risks and benefits.
As with any form of surgical intervention , long-term results define success.
As with brain , these deficits in muscle are an early event , occurring prior to appearance of amyloid plaques.
As with glucocorticoid-induced osteoporosis , there is an increasing awareness that simultaneous management of osteoporosis is necessary when performing estrogen or androgen deprivation therapy.
As with many drugs , dosage is of great importance.
As with many other tissues and organs , the immune system is also affected by age.
As with most other biological phenomena , understanding the nature of genetic and environmental interactions is central to understanding of reproductive aging.
As with other Federal agencies , FDA is required to assess the costs and benefits of its significant regulatory actions.
As with other organs endometrial functions are altered with the advancing age.
As with pre- and post-operative dietary recommendations , evidence-based nutritional advice from healthcare professionals during and after cancer treatment is often vague or conflicting.
As with so many other aspects of family building , assisted reproductive technologies have transformed the possibilities for-and spawned heated debates about-maternal age.
As women age , low FMR1 alleles affect IVF pregnancy chances by reducing egg / embryo quality by mechanisms other than embryo aneuploidy.
As workers near retirement , many experience a medical event that limits the ability to work.
As yet , there is insufficient knowledge on the clinical features , pathophysiological background and consecutive algorithms for stepped-care treatment.
As yet there is relatively little information focused specifically on mitochondrial biogenesis and its regulation by PPARγ coactivators and their modulators such as SIRT1.
A syllable identification task was presented in auditory-only , visual-only , and audio-visual congruent and incongruent conditions.
A symmetrical measure of self-rated cognitive performance predicted intraindividual change in subjective well-being in middle-aged but not older adults.
A symmetric funnel plot , the Begg's test ( P > @number@ ) , suggested that the data lacked publication bias.
A symmetric funnel plot , the Egger's test ( p = @number@ ) suggested a lack of publication bias.
Asymmetric pigmented follicular openings by dermoscopy correlated with follicular localization of pagetoid cells by RCM ( κ = @number@ P < @number@ ) .
Asymmetries were common ( e.g. , bitter-sour confusions were less frequent than sour-bitter confusions ) .
Asymmetry indexes were similar between the different days evaluated.
Asymmetry of results in dichotic testing increases with age , and may reflect on a lack of inter-hemisphere transmission and cognitive decline.
Asymptomatic carriers of the FD gene mutation all had thinner RNFL ( @number@ % globally , p < @number@ ) .
Asymptomatic meniscal lesions are common incidental findings on knee MRI of the middle-aged or older person.
Asymptomatic , never-smoker subjects considered free of relevant disease after spirometry and echocardiography underwent chest HRCT.
Asymptomatic significant ( ≥50% ) carotid stenosis ( ASCS ) is a frequent finding in the aging population.
Asymptotic properties of the proposed estimator are established.
A synergistic interaction was also observed between mid- and late-life activity in reducing risk of incident MCI.
A synergy was detected between 405V and APOE ε4 ( P = 0.001 , OR = 0.530 ) .
A synthesis of the literature concerning fillers and related side effects was also reported.
A systematic analysis was performed on mortality and morbidity data to estimate prevalence , deaths , and disability-adjusted life years ( DALYs ) .
A systematic appraisal of peer-reviewed , English language research was conducted.
A systematic approach to skin assessment is also provided and general skin care with a focus on personal hygiene is discussed.
A systematic approach was used to identify AβPP-selective BACE inhibitors ( ASBI ) and to evaluate their in vivo ability to modulate AβPP processing selectively.
A systematic computerized literature search using an iterative manipulation process of the keywords : obesity , elderly , weight loss.
A systematic literature review was performed on studies evaluating sensitivity and specificity of blood-based markers for early detection of CRC.
A systematic literature search was performed in PubMed , ISI Web of Knowledge and EMBASE to find relevant studies published until @date@ .
A systematic multidisciplinary approach enhances the dialogue with patients and caregivers to discuss their needs and their attitude towards care.
A systematic online search was conducted on MEDLINE , ISI Web of Science , Scopus , and SPORTDiscus databases.
A systematic PubMed / EMBASE / CINAHL / SCOPUS search until @date@ without language restrictions was conducted.
A systematic recruitment structure based upon blocks of @number@ patients initially focused on leukemia and lymphoma survivors and patients eligible for pilot studies.
A systematic review and meta-analysis was conducted.
A systematic review based on the PRISMA flow diagram was conducted.
A systematic review has the potential to be conducted given the consistency in caregiver burden and depression as outcomes.
A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until @date@ .
A systematic review of randomized controlled trials was therefore conducted of the databases MEDLINE and SCOPUS up to @date@ .
A systematic review of studies published from @date@ to @date@ , from five databases , was undertaken.
A systematic review of the literature was performed to identify reports describing the anesthetic management of patients with these conditions.
A systematic review of the potential benefits of dance on falls and fear of falling is lacking.
A systematic review using MEDLINE , EMBASE , and PUBMED was performed.
A systematic review was conducted.
A systematic review was conducted to determine the impact of dietary and supplemental interventions focused on calcium and vitamin D over the past @number@ years.
A systematic review was undertaken to identify PA correlates.
A systematic search of current literature was conducted , including only full papers and excluding allogeneic hematopoietic stem cell transplant recipients.
A systematic search of seven databases was conducted to identify literature concerning changes in calibration in response to changes in action capabilities.
A systematic search using online databases was used to source articles.
A systematic strategy for managing CKD patients is warranted.
A system for diagnosing health problems from gait patterns of elderly to support their independent living is proposed in this paper.
A system for removing these cytoplasmic substrates is essential for maintaining homeostasis.
A system perspective provides insight into what changes to make , and system maps are critical tools to help gain that system perspective.
A Systems Biology approach based on gene interaction patterns can compensate adequately for the lack of species-specific genomics information.
A Systems Biology / pathway approach will be used to identify genetic factors for subject selection / enrichment.
At 12-month follow up , there were @number@ new fractures , @number@ in each group.
At 15months of age , a transgene-specific spatial learning deficit was dependent on the period of training in the Morris watermaze.
At 1-month follow-up after final treatment , investigators rated mean improvement of 26-50% for wrinkles , 51-75% for pigment , and 26-50% for texture.
At 1-month follow-up , there were no significant differences in the proportions of participants with moderate to severe symptoms.
AT1RaAbs could be used to stratify patient risk and to identify patients who can benefit from angiotensin receptor blocker treatment.
At 1-year follow-up ( @date@ ) , participants from the intervention group were interviewed using a standardized questionnaire.
At 1-year follow-up , @number@ demonstrated persistent mild parkinsonian signs , while @number@ recovered ( i.e. , transient ) .
At 1-year follow-up , @number@ ( @percent@ ) subjects were classified as CGI-I responders.
At 23-28 weeks GA , laminar organization appeared less typical , and borderlines among them appeared obscured.
At 2 ( @date@ ) wk of diet , one 60-min bout of bicycle exercise ( @percent@ of maximal oxygen uptake ) was performed.
At 6-month follow-up , @percent@ of patients had a minimum 10-point reduction in their ODI scores ( p < @number@ ) .
At 6months , IGF-1 significantly increased by Δ @number@.3±10.3ng / ml in the TT-group compared to placebo ( P = 0.03 ) .
AT8-positive , TOC-1-positive , and Tau C3-positive NFT densities were unchanged , whereas only AT8-positive neuropil thread density was statistically higher in AD subjects.
At a cellular level , oxidative damage to mitochondria results in acidification of the cytoplasm and release of cytochrome c , causing apoptosis.
At a clinical level , the challenge is to assess the individual risk factors and apply evidence-based individually tailored , multifactorial interventions.
At a cutoff of @date@ , the six-item CDT had a sensitivity ( SN ) of @number@ and a specificity of @number@
At a cutoff value of @number@ mg / dL , C-reactive protein had a sensitivity of @percent@ and a specificity of @percent@.
At a cutoff value of @number@ ng / mL , procalcitonin had a sensitivity of @percent@ and a specificity of @percent@.
At admission , subjective global assessment ( SGA ) , body mass index , patient demography were collected.
At admission , the main nutrition evaluation was subjective global assessment ( SGA ) .
At age 75 + further substantial decline in most activities occurred.
At age @number@ and @number@ years women suffered more from loneliness than men , while men experienced feeling needed more than women.
At age @number@ participants kept diaries of their food intake for 1week.
At age @number@ they both developed cervical myelopathy as a cardinal manifestation.
At age @number@ years and above , there was a significant tendency for MF to be located at the level of occlusal plane.
At ages 50-72 advanced parental age also predicted higher mortality , though not as strongly.
At ages @number@ and @number@ depressive symptoms correlated with higher negative , and lower positive , SRET processing.
At a high level of functional impairment , the inverse associations between indices of social support and depressive symptoms were attenuated.
A take-home message is that increasing evidence supports the health protective features of psychological well-being in reducing risk for disease and promoting length of life.
At all ages and both sexes the fewest years were spent frail.
At all ages , and in both numbers and proportion , women have longer life expectancy but shorter DFLE than men.
At all ages , the female heart is equipped with a larger pool of functionally competent hCSCs and younger myocytes than the male myocardium.
At all follow-up times , the incidence of walking and stair climbing limitations was higher in participants with VA , CS , or SA impairment.
At all interviews global cognition was assessed using the Mini-mental State Examination ( MMSE ) .
At all @number@ assessments , individuals with schizophrenia performed more poorly than the other diagnostic groups on the @number@ cognitive measures.
At all , @number@ out of @number@ ( @percent@ ) patients had at least one grandparent originating from Italy.
At all three points , the brow was higher in older compared with younger subjects.
At all time points , FLO and SPA improved ( P = 0.008 and P = 0.01 , respectively ) .
At all visits , subject perception of the association of Retinol @number@.2% / LR2412 @percent@ was either comparable to or better than tretinoin @percent@ cream.
At a median follow-up of @number@ years , @number@ patients ( @percent@ ) had died.
At a more specific level of analysis , resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function.
At an infection intensity of @number@ EPG , we estimate a sensitivity of @percent@ for one sample and @percent@ for two samples.
At annual reassessment , regular exercisers demonstrated better preservation of functional status and a lower rate of falling than nonregular exercisers.
At any age , women had significantly lower serum testosterone / estrone ratio than age-matched men ( p < 0.01 ) .
At a population level , the challenge is to improve the health and well-being of all older people to reduce the incidence of falls.
At a population level , women and men differ in a wide variety of behavioral traits and in the probabilities of developing certain mental disorders.
A target date of @number@ was articulated as the point by which master's preparation for advanced practice nurses would be replaced by doctoral level education.
A targeted detection and treatment of factors that threaten functional independence , through comprehensive geriatric assessment , might promote this.
A Task Force on designing trials of nutritional interventions to slow cognitive decline in older adults was held in Toulouse in @date@ .
At a stable overall error rate , higher age was associated with a greater proportion of undetected errors.
At autopsy , clinicopathological diagnoses were made in @number@ cases ( @percent@ ) .
Ataxia telangiectasia and related disorders with defects in these pathways illustrate that such defects can lead to early childhood neurodegeneration.
Ataxia-telangiectasia ( A-T ) is a rare neurodegenerative immunodeficiency disorder caused by mutations in the ataxia telangiectasia mutated gene.
Ataxia with oculomotor apraxia @number@ is caused by mutation in the APTX gene , which encodes the DNA strand-break repair protein aprataxin.
Ataxin-7 has a known function in the histone acetylase complex , Spt / Ada / Gcn5 acetylase ( STAGA ) chromatin-remodeling complex.
Atazanavir and ritonavir plasma concentrations were measured by validated high-performance liquid chromatography ( HPLC ) .
At baseline , AD patients were characterized by diminished ether phospholipids , phosphatidylcholines , sphingomyelins and sterols.
At baseline , age was inversely related with the level of total daily activity ( estimate , @number@ S.E. @number@ p < 0.001 ) .
At baseline , a greater perception of the caregiver's burden was observed in the live-in caregivers.
At baseline , a limited data set was collected for @number@ people and a more comprehensive data set for a stratified sample of @number@ people.
At baseline and at follow-up , a 37-item version of the Mini-Mental State Examination ( 37-MMSE ) was administered.
At baseline and @number@ mo , serum fatty acids , bone turnover , and inflammatory markers were analyzed.
At baseline and post intervention , muscle volume ( MV ) was measured by CT-scan.
At baseline , clinical and demographic data were collected.
At baseline , elevated concentrations of G-CSF and reduced concentrations of IL-17 were associated with faster psychomotor speed.
At baseline , fitness measures were positively correlated with peak levels of cortisol and a greater fall in cortisol concentration from peak levels to midday.
At baseline , four variables emerged as significantly and independently correlated with PR interval : Gender , age , weight , and heart rate.
At baseline , height , body mass index ( BMI ) and handgrip strength were measured and compared with those in a western reference population.
At baseline , HF patients spent an average of @number@ ( SD @number@ ) minutes per day sedentary.
At baseline , higher adherence to Mediterranean diet was associated with better lower body performance.
At baseline , higher CSF Apo-E levels were associated with higher total and phosphorylated CSF tau levels.
At baseline , higher isolation and loneliness were associated with lower levels of hedonic and evaluative well-being.
At baseline , higher t-PA was associated with lower CBF ( p = @number@ ) .
At baseline , increasing age , presence of metastasis and presence of comorbidity had a negative impact on QLQ-C30 and QLQ-PR25 scores.
At baseline in @number@ a total of @number@ persons aged @number@ or @number@ agreed to participate in the intake survey.
At baseline , IVCM was performed at the site planned for surgery , and was repeated after @number@ months at bleb site.
At baseline , maximal isometric thigh strength ( dynamometer chair ) , and midthigh muscle area and muscle fat infiltration were assessed with computed tomography.
At baseline , mBDNF and tBDNF levels were comparable in the two groups , TG and CG.
At baseline , MCRv was associated with deficits in attention and language as well as in overall cognitive status.
At baseline , NEPA and exercise habits were assessed from a self-administrated questionnaire and cardiovascular health was established through physical examinations and laboratory tests.
At baseline neurological examination , @number@ ISNAs were selected.
At baseline , no differences were found in LM , FM , and FM% among the groups in any of the body segments.
At baseline , @number@ men ( @percent@ ) had a coronary artery calcification score higher than @number@ Agatston units , reflecting severe atherosclerosis.
At baseline , @number@ participants underwent magnetic resonance imaging ( MRI ) , @number@ returned for the first and @number@ for the second follow-up.
At baseline , @number@ patients ( @percent@ ) had a good SRH and @number@ patients ( @percent@ ) had poor SRH.
At baseline , @number@ ( @percent@ ) required assistance with ADLs.
At baseline , @number@ residents were diagnosed with dementia , and another @number@ developed dementia during follow-up.
At baseline , @number@ were low-calorie sweetener non-users ( @percent@ men ) and @number@ participants were low-calorie sweetener users ( @percent@ men ) .
At baseline , one quarter of the participants had high levels of anxiety.
At baseline , over @percent@ of participants had Timed Up-and-Go ( TUG ) test times of @number@ s or more , which indicates below-normal performance.
At baseline , participants had completed a standardized questionnaire including demographic , lifestyle , medical and reproductive characteristics.
At baseline , participants underwent MR imaging at 3T , extensive neuropsychological testing , and genotyping.
At baseline , participants were administered a cognitive battery that included the digit symbol substitution test ( DSST ) .
At baseline , @percent@ of participants had diabetes and @percent@ developed diabetes during the study.
At baseline , @percent@ , @percent@ and @percent@ were respectively sub-optimal , insufficient , and deficient for VitD.
At baseline , persistent pain affected @percent@ of participants and was associated with worse depressive symptoms and more limitations in activities of daily living.
At baseline she reported only subtle difficulty driving and performed normally on cognitive tests , but already demonstrated atrophy in left visual association cortex.
At baseline , subjects were asked to rate their health using a single-item health question.
At baseline , symptoms were worse in men with depression and microvascular complications but did not correlate with T levels.
At baseline , the AEX + WL group consumed slightly more protein than the WL group ( P < 0.01 ) .
At baseline , the groups did not differ in measures of health or falls risk factors.
At baseline , there were no significant differences in self-rated health and PA between the experimental and control group.
At baseline , the SPPB scores did not differ between the @number@ groups.
At baseline , trained investigators graded the severity of facial skin photoaging using a validated 6-grade scale during a clinical examination.
At baseline , we measured waist circumference and assessed metabolic syndrome and diabetes according to established guidelines ( N = @number@ ) .
At baseline , WML volume was measured using a semi-automatic method on T2-weighted MRI.
At baseline , women self-reported a wide range of lifestyle , clinical , and dietary factors.
At baseline , young adults preferred autonomy goals , whereas older adults preferred generative goals.
At baseline , young subjects had higher MVC force and maximal motor unit firing rate , and shorter AHP duration , compared with older subjects.
At best , this is just an association with a higher risk of CAD in this age group.
At birth , these tissues exhibit the effects of residual maternal estrogens.
At both baseline and week @number@ a @number@ mm punch biopsy was obtained from the subjects ' randomized forearms.
At both depths , Scotchbond blocked significantly less fluorescence.
At both @percent@ and @percent@ 1RM , considerable interindividual variability was observed in the number of repetitions completed.
At both physiological and pharmacological concentrations , melatonin attenuates and counteracts oxidative stress and regulates cellular metabolism.
At both sites , cortical bone area , vBMD , and thickness showed significant quadratic association with age with significant decrease beginning after midlife.
At both time points , all subjects underwent full medical and neuropsychological evaluations , lumbar punctures , and magnetic resonance imaging examinations.
At both time points the use of VMFO was associated with female gender and higher number of used medications.
At both waves @number@ and @number@ the CES-D 11-item scale was used to identify those who met criteria for CRLDS.
At computed tomography , pulmonary actinomycosis usually appears as chronic segmental airspace consolidation containing necrotic low-attenuation areas with peripheral enhancement.
At crossover , EPC levels did not change compared with baseline , but significantly increased at study end.
At @date@ @percent@ had a diagnosis of biliary colic or cholecystitis , while @percent@ had a diagnosis of cholangitis , pancreatitis , or choledocholithiasis.
At day @number@ all placebo-treated patients requested active local therapy ( days @number@ and @number@ ) vs only three patients under active treatment.
At day @number@ Ce increased with age.
At day @number@ improvements were reported by two-thirds of patients and by nearly @percent@ of blinded reviewers.
At day @number@ @number@ patients showed slightly better correction in the cannula-treated sides.
At day @number@ patients evaluated pain ; the treating investigator evaluated changes in NLF depth.
At day @number@ @percent@ ( n = 20 ; @percent@ C. @date@ @number@ @number@ P = @number@ ) responded to treatment.
At day @number@ @percent@ ( n = @number@ @number@ C. @date@ @number@ @number@ P < @number@ ) responded to treatment.
At day @number@ @percent@ of patients perceived improvement in the skin laxity of the lower half of their face / neck.
At days @number@ and @number@ patients displayed greater instances of bruising , redness , and swelling in the needle-treated sides.
At discharge , @percent@ of patients had improved and in-hospital mortality rate was @percent@.
At each assessment these relationships were poorer for children with intellectual disability.
At each ontology level , the amount of atrophy was evaluated , providing a unique view of low-granularity analysis.
At each visit , depressive symptoms were measured with the CES-D and WML volumes were quantified from structural magnetic resonance imaging scans.
At each visit , participants completed standard questionnaires on alcohol use , chronic diseases , and behaviors.
At each visit , participants were administered the 14-item Perceived Stress Scale ( PSS ) , which quantifies stress experienced in the previous week.
At each visit , subjects were evaluated using clinical photography and written self-assessment.
At each wave ( @number@ @number@ and @number@ ) respondents estimated the duration ( minutes ) of WfT in the previous @number@ days.
At each wave , participants reported recent sleep medications use and falls since the last wave , and were evaluated for balance and walking speed.
At-ease walkable proximity to medical facilities was positively associated with a better GDS score.
At EGEA2 , neither PC1 nor PC2 were related to exacerbations , asthma attacks , asthma symptom control , lung function , or allergic diseases.
A telephone-administered questionnaire obtained information on socio-economic , pre- and post-injury psychological and heath characteristics.
At elevation , workers depend heavily on sensory information from their feet to maintain balance.
A temporospatial principal component analysis was conducted.
A tendency for decreased neuronal inflammation was observed.
A tendency of age-related increase in Co , Fe , Hg , Sc , and Zn content was observed.
A tendency towards significance was identified for the ankle plantar flexors ( r = @number@ p = @number@ ) .
At enrollment in @number@ longitudinal clinical-pathologic cohort studies , @number@ older individuals without cognitive impairment completed a standard conscientiousness measure.
At entry , the Fugl-Meyer Scale was administered to assess motor function according to limb synergies.
At equivalent concentrations of ApoA1 , HDL isolated from all subjects irrespective of diagnosis was equally effective at mediating RCT.
A test battery including a criterion task and near , intermediate , and far transfer tasks was administered before and after training.
A test for association with the entire region was also significant ( meta-P = @number@ × 10 ( @number@ ) ) .
A test for effect of adjunctive procedures was performed.
A test with a global late Quaternary mammal database well supports the model.
At every @number@ weeks , the effectiveness was assessed with a global photodamage score , photographs , and image analysis using replicas and visiometers.
At every stage , age increased rapidly for both parents.
At-fault collision involvement for @number@ years prior to enrollment was obtained from state records.
At follow-up , frail participants showed significant improvement in physical function , with DASI and SF-12 PCS scores improving by @percent@ and @percent@ , respectively.
At follow-up , group @number@ ducts showed a greater interval diameter increase than the other groups ( P < @number@ ) .
At follow-up , measures of BMI , blood pressure , and physical activity were obtained.
At follow-up , the aerobic and cognitive exercise program was found to have resulted in significant positive effects.
At follow-up , the primary end point was all-cause mortality.
At follow-up , there were no significant differences between PwD in the three groups on any outcomes.
At FU1 , pBDNF and ADAS-Cogscore decreased significantly.
Atg7 deficiency significantly affected expression of lipid metabolic genes.
Atg7 deficient KC displayed increased prostanoid signaling and a pro- mitotic gene expression signature as compared to the WT.
At genotyping test costs < €35 per test , genotyping was dominant.
At graduation , most of them had a normal BMI.
A thematic analysis of the data revealed mixed opinions on the impacts of task shifting on the quality of care.
A thematic content analysis was conducted using the constant-comparative method.
A theoretical definition is discussed.
A theoretical framework is presented that informs the design of a technology enhanced screening platform for wellness.
A theoretical model was developed that allowed an in silico investigation into the cellular consequences of increased T-SCE frequency.
A theory-based hierarchy was imposed on time-invariant latent classes of LoD-endorsements.
A therapy combining anti-aging mesotherapy , botulinum toxin and filler injections , offers full treatment of the @number@ biological levels of the covering tissues.
Atherogenic dyslipidemia may play a relevant role , especially in T2DM women.
Athero @number@ ; 158 : 195-8. ] .
Atherosclerosis and its associated complications remain the primary cause of death in humans.
Atherosclerosis has been thought to be a disease of modern society , and its occurrence was closely related to contemporary diet and lifestyle.
Atherosclerosis , hypertension , and CAA are the most common causes of blood-brain barrier ( BBB ) lesions.
Atherosclerosis is an arterial disease process characterized by the focal subendothelial accumulation of lipoproteins , immune and vascular wall cells , and extracellular matrix.
Atherosclerosis is an inflammatory disease and hyperlipidaemia is one of the main risk factors for aging , hypertension and diabetes.
Atherosclerotic cardiovascular disease ( ASCVD ) remains the leading cause of death , especially in older adults.
Atherothrombotic carotid stenosis is one of the most important etiologies behind this event.
At higher speeds , pedestrians tend to accept smaller time gaps , i.e. they initiate riskier crossings.
At high strength values the indirect tensile test is less sensitive than the flexural test.
A third aim addresses how modernization shapes human life histories and sociality.
A third assessment , evaluating the treatment follow-up and the quality of life , will be made @number@ months after the initial diagnosis.
A third goal , increased socialization , aligns with relevant psychosocial factors and reflects the need to engage with others.
A third group of older subjects used the Falcon.
A third latent factor representing \ "non-NP-related NFT \ " was also constructed.
A third marker in the body region of BCL2 was discovered in a candidate approach testing biomarkers reported in the literature.
A third of these have already been reported with respect to ALS , leaving @number@ novel variants all open for further investigation.
A third of those aged over @number@ met the standard in agility and dynamic balance.
A third one has been referred to as \ "well-meant , but badly done \ ".
Athletic children are prone to overuse injuries , especially at the heel and knee.
A thorough characterization of η-processing of APP is critical for a better understanding of AD pathogenesis and insights into results of clinical trials of AD.
A thorough effort in investigating every possible involvement of GH / IGF-I axis is warranted , in the light of future possible therapeutic strategies.
A thorough evaluation of renal function is important , since renal function decreases with age.
A thorough evaluation of residents ' drug use , medical diagnoses and healthcare resource utilization was performed.
A thorough knowledge of the anatomy of the aging face is essential to a safe and effective operation.
A thorough review of English language literature using EMBASE / Medline and PubMed has been performed.
A thorough understanding of SN distribution may help reveal reasons for their formation.
A thorough understanding of the aging process can help assessing the efficacy of dietary interventions aimed at reducing the risk of aging-related diseases.
A three-variable predictive model resulted to be optimal for RILF.
A threshold established by logistic regression allowed the separation of the groups with @percent@ specificity , 83·2% sensitivity and 93·3% total accuracy.
A threshold of @number@ % for both scales ( BBS-70 and BI-70 % ) was set , according to the aims of the study.
A threshold of @percent@ was applied to differentiate between adherence and non-adherence.
A threshold P value of @number@.0×10 ( @number@ ) was set for genome-wide significance after Bonferroni correction for multiple testing.
AT-ICH is associated with a risk of ongoing bleeding , death , or disability.
At IE , daily-living skills corresponded to age≤1.6years in 29 / 46 ( @percent@ ) .
At imaging , malignant ovarian tumors usually appear predominantly solid or heterogeneous and are larger than benign tumors.
A time- and concentration-dependent decrease in survival and a concentration-dependent decrease in glucose uptake were observed in primary cortical cultures treated with HHE.
A timely and correct diagnosis might result in better targeted treatment strategies , adequate patient counseling , and early recognition of disease-specific complications.
A time-stratified bidirectional design was used to select control days for each ER visit on the same day of the week during the same month.
A time to peak value > 108 seconds was characteristic for degenerative changes with sensitivity @percent@ and specificity @percent@.
At inclusion , patients were aged from @number@ months to @number@ years.
At increased levels of cellular damage whole organelles can be removed via autophagy , a process that depends on the activity oflysosomes.
At INR < 4 , there was no difference in hemorrhage risk by eGFR ( all P ≥ @number@ ) .
A \ "tired \ " or \ "sad \ " look implies that the complex eyebrow-upper eyelid are showing one or more of these signs.
At issue here is the social position of the old citizens and the way in which they are regarded by their fellow citizens.
At issue is whether the various dimensions of temporal processing decline at the same or at different rates across age.
A titration schedule was implemented to reach a dose that was safe and effective for IL-6 reduction.
At its innermost aspect it associates with peripheral components of chromatin and thereby contributes to the organization of interphase chromosomes.
At its peak , the rations dropped to as low as @number@ calories per day.
At Kanizsa illusion appearance , the ratio of the separation between discs and disc diameter was smaller when we used larger disc diameters.
At last follow-up , all @number@ patients had died , with a median survival of @number@ months.
At last @number@ papers fulfilled the criteria.
At last , qPCR experiments demonstrated the compatibility of extracted DNA with routine DNA downstream analyses.
At last small-worldness was used as feature for the SVM classifier.
At last , the promising therapeutic strategies to sensitize the resistant patients are also briefly discussed.
At later stages of AD reactive astrocytes are associated with neurite plaques , the feature commonly found in animal models and in human diseased tissue.
At later stages , when clinical symptoms generally occur , NFT involve widespread limbic and association cortices.
At late stage , their survival time may be prolonged when receive chemotherapy at least @number@ cycles.
ATL biosynthesis requires cyclooxygenase-2 acetylation by aspirin.
At least half of them simultaneously highlighted independence from family and dependence on family.
At least @number@ million people worldwide currently have dementia.
At least one account ( Dynamic Integration Theory ) makes the additional prediction that an accompanying effect of aging is a narrowing of affective space.
At least one common genetic variant strongly associated with pulmonary fibrosis appears to have prognostic implications for patients.
At least one component of the APA was absent in @percent@ of all trials.
At least one delirium symptom was detected in @number@ patients ( @number@ % ) during hospitalization.
At least one item was missing from @number@ ( @percent@ ) of the MMSEs.
At least @percent@ ( 21 / 31 ) of these patients were compliant at follow-up.
At least @percent@ of those diagnosed with ALS or FTD are known to carry an autosomal dominant genetic mutation.
At least three studies have used external noise paradigms to investigate the cause of contrast sensitivity losses due to healthy aging.
At least two fractions had significant hemolytic activities.
At low concentrations , all four NTPs could support helicase activity with varying effectiveness depending on the included divalent cation.
At low-doses , aspirin acts mainly by an irreversible inactivation of platelet cyclooxygenase ( COX ) -1 activity.
At low doses , certain agents may decelerate aging and age-related diseases.
At lower doses , they had no unfavorable effects on cholesterol efflux or overall RCT in vivo.
ATM ( ataxia-telangiectasia mutated ) protein kinase is a key regulator of cellular responses to DNA damage and oxidative stress.
At maximal exercise , they had a reduced hypoxic ventilatory response but similar maximal power output reduction compared with young individuals.
At menopause transition , dropping estradiol potentially enhances immunosenescence effects posing postmenopausal women at additional , yet specific risks.
At midlife , there were no significant differences of PA level between experimental and control groups.
At mitochondria , it performs regulatory homeostatic functions and contributes to mitochondrial quality control.
At Month @number@ LFS responder rates were @percent@ for VYC-15L versus @percent@ for NASHA.
At Month @number@ @percent@ and @percent@ of subjects reported improvement in FACE-Q Satisfaction With Lips and Satisfaction With Lip Lines , respectively.
At month @number@ @percent@ of participants reported satisfaction , with appearance scores between @number@ and @number@
At month @number@ the intervention group received individual lifestyle counseling and oral hygiene instruction.
At more advanced stages , atrophy patterns largely converged across AD variants.
Atmospherically relevant doses of wood combustion particles significantly increased cell death in all but the asthma cell model.
At most they are secondary related to the neurodegenerative process.
ATM silencing and the supplementation of antioxidants , N-acetyl-L-cysteine ( NAC ) or trolox , did not reduce the number of senescent cells.
At multiple logistic regression analysis , the presence of high values of BMI and glucose was related to a higher probability to detect entheseal lesions.
At near-term age the brain undergoes rapid growth and development.
At neuropathological examination , @percent@ of patients in the FTLD without ALS group showed aggregations of TDP-43 in the spinal motor neurons.
At no assessment period did coping improvement and interpersonal support group intervention participants differ in depressive symptoms.
At no risk of viral escape , maintenance therapy , @number@ days per week , would quasiuniversally offer @percent@ cuts off of current overprescriptions.
At @number@ days after operation , the viability of the flaps from both groups was evaluated.
At @number@ days , a mean @number@ mm submental lift was noted ( p = @number@ ) .
At @number@ days , mean scores remained significantly lower than baseline ( p < @number@ ) .
At @number@ days of age , HFB rats exhibited greater FPS than LFB rats.
At @number@ hours , micro cracks remained shallow ( @number@ µm ) .
At @number@ hours , micro cracks remained superficial ( @number@ µm ) for type D implant and depth of t-m transformation increased to @number@ µm.
At @number@ hours , number of micro cracks increased at the surface to an average depth of @number@ µm.
At @number@ hours , these features remained superficial at @number@ and @number@ µm , respectively.
At @number@ hours , type B implant presented micro cracks ( @number@ µm ) and grain transformation ( @number@ µm ) .
At @number@ kHz , the high frequency of hearing and cognition may share similar common environment.
At @number@ minutes after the exercise session , the prevalence of hypotension was significantly higher in water- than in the land-based protocol.
At @number@ mm , fissure sealants blocked more fluorescence than adhesives , and did not show significant changes with aging.
At @number@ mm , Scotchbond and FluroShield showed the lowest intrinsic fluorescence , but only Scotchbond showed no chagnes in fluorescence with aging.
At @number@ month , all participants were interviewed by telephone to determine whether they made a quit attempt.
At @number@ months after eperation , contrast agent endoleak was found in @number@ cases ( @percent@ ) by CTA.
At @number@ months after operation , contrast agent endoleak was found in the remnant aneurysm cavity of @number@ cases ( @percent@ ) .
At @number@ months , a thicker , multicelluar epidermis and an evident increase in collagen were observed.
At @number@ months , IOP reduced by @percent@ , @percent@ , and @percent@ in groups @number@ to @number@
At @number@ months , no differences in cognitive function were found in the intensive BP-lowering trial or in the fibrate trial.
At @number@ months , @number@ patients had died in the home oxygen plus home NIV group vs @number@ in the home oxygen alone group.
At @number@ months , @number@ percent of subjects rated their results as \ "satisfactory \ " or better.
At @number@ months , @number@ ( @percent@ ) patients had died , @number@ of them , from the non-intervention group.
At @number@ months of age , he was sent to metabolic consultation because of facial dysmorphy and short stature.
At @number@ months , only @percent@ were living at home , dialysis independent.
At @number@ months , only the difference in number of drinks remained statistically significant ( RR @number@ @percent@ CI @number@.76-0.99 ) .
At @number@ months , @percent@ of subjects maintained a ≥1-point improvement in Investigator GLSS and @percent@ maintained WSS of or Mild.
At @number@ months , the IIEF-5 score significantly decreased from24 to @number@ ( p < 0.0001 ) .
At @number@ months , the mortality rate increased to @percent@ and @percent@ , respectively ( p = @number@ ) .
At @number@ months , use of alternate transportation was similar ( between-group difference @number@ @percent@ CI = @number@.4-1.6 , P = @number@ ) .
At @number@ months , we observed an increase in BG MI ( P = @number@ ) and in FGM ( P = @number@ ) .
At @number@ @number@ @number@ @number@ and @number@ days , the investigator evaluated AEs and NLF correction.
At @number@ @number@ @number@ @number@ and @number@ h after stripping , TEWL measurements were taken , and epidermis samples were collected.
At @number@ test intersections , participants attempted to pass through a gap between @number@ moving , car-sized blocks without stopping.
At @number@ time points , they were obtained from @number@ others when cognitively normal and @number@ to @number@ yr later when diagnosed with AD.
At @number@ weeks mice were evaluated in a Comprehensive Lab Animal Monitoring System ( CLAMS ) .
At @number@ weeks post treatment , the score decreased to @number@ @number@ @number@ and @number@
At @number@ weeks , there were no significant differences in patient satisfaction between the two sides.
At @number@ years of age , more intelligent children have a slightly thinner cortex than children with a lower IQ.
At @number@ years of age , tall peers were expected to live two years less than short conscripts.
At @number@ years of age , the difference in life expectancy was @number@ years for men and @number@ years for women.
At @number@ year , the decrease in pain ( P = @number@ ) and stiffness ( P = @number@ ) remained constant.
At @number@ year , we assessed recurrent cerebrovascular events and dependency and repeated the MRI.
A-to-I RNA editing is particularly widespread in the brain and is known to play important roles in neuronal functions.
Atomic force microscopy revealed that PDI works as a placeholder to prevent early non-native disulfide bond formation and further misfolding.
At one month , @percent@ requested additional hyaluronic acid gel for a touch-up injection.
A Toolmaker's microscope ( Mitutoyo ) was used to measure ( um ) dye penetration.
A top down approach with financial incentives , together with public education to help drive policy changes , are key drivers of change.
Atopic dermatitis is a chronically relapsing inflammatory skin disease often associated with respiratory allergy.
A topology-preserving manifold representation of the fetal skull enabled design of bespoke scale-invariant image features.
Atopy has rarely been considered in the clinical assessment of the geriatric respiratory patient.
Atopy was defined as a positive result in the Phadiatop test according to guidelines by the manufacturer.
Atorvastatin completely ameliorated impaired LDL apoB catabolism.
Atorvastatin is active in promoting angiogenesis and modulating inflammation.
Atorvastatin ( @percent@ ) and simvastatin ( @percent@ ) were the most widely used statin drugs.
A total ECog score was used to represent global disability level.
A total number of fibroblasts in dermis decreased with age.
A total number of @number@ brain VOIs were selected for quantitation analysis.
A total number of @number@ osteoporosis-related fractures occurred.
A total @number@ patients underwent stepwise regression to identify those factors predicting survival.
A total of 14 / 40 ( @percent@ ) patients with an objective swallowing impairment did not have any subjective swallowing symptoms.
A total of 56 / 60 and 58 / 60 men from the active treatment and placebo group , respectively , completed the study.
A total of eleven acceptance criteria are excerpted from this and a diagram is created to show their connections.
A total of @number@ abstracts were screened , @number@ were fully reviewed , and @number@ papers were eventually included.
A total of @number@ adults aged 20-82 took part in the study.
A total of @number@ adults over @number@ years of age were screened for S. aureus nasopharyngeal and oropharyngeal carriage.
A total of @number@ adults performed three parallel versions of cognitive tests on two occasions separated by an average of @number@ years.
A total of @number@ adverse events ( @number@ heart failures and @number@ cardiovascular deaths ) occurred during a median follow-up of @number@ months.
A total of @number@ alcohol gel and soap dispensers were instrumented and @number@ nurses were provided with the personal wearable electronic monitors.
A total of @number@ and @percent@ had a TLB or LELB T-score of less than @number@ and a LEP in the lowest quartile.
A total of @number@ apparently healthy adults of varying ages were studied.
A total of @number@ articles published in English were retrieved and considered.
A total of @number@ articles were identified for inclusion in this narrative review.
A total of @number@ articles were selected for inclusion.
A total of @number@ Asian Americans from Chinese , Filipino , Korean , and Vietnamese backgrounds were studied.
A total of @number@ calcaneal broadband ultrasound attenuation ( BUA ) and SOS observations were obtained between the ages of @number@ and @number@ years.
A total of @number@ candidate gene studies examining @number@ polymorphisms in @number@ genes as well as a genome-wide association study ( GWAS ) were included.
A total of @number@ cases of falls / fractures with at least one hospitalization / ER visit following the use of antipsychotic agents were identified.
A total of @number@ child observers aged 6-16years and @number@ young adult observers ( @number@.66 + / -2.74years ) participated.
A total of @number@ children attending the 2001-2002 school entrance health examination in the city of Aachen , Germany , were included into this study.
A total of @number@ Chinese children and adolescents between the ages of @number@ and @number@ years were recruited from southern China.
A total of @number@ Chinese older adults ( age 60 + ) participated in focus group interviews.
A total of @number@ Chinese older adults completed both waves of data collection.
A total of @number@ Chinese subjects aged 50-92 years participated in this study.
A total of @number@ Chinese / Taiwanese , Korean , and Indian H1B workers participated in in-depth qualitative interviews.
A total of @number@ clinical Aspergillus fumigatus isolates were collected during the study period.
A total of @number@ common and rare variants were identified in patients and controls.
A total of @number@ community dwelling adults aged 60 + ( @number@ females , mean age @number@ ) were participated in this study.
A total of @number@ community-dwelling elderly persons , aged 70-74 years , were enrolled.
A total of @number@ community-dwelling older adults aged ≥60 years were recruited by stratified random sampling.
A total of @number@ conjunctival specimens were screened for C. trachomatis DNA targeting the plasmid gene.
A total of @number@ consecutive middle-aged , HIV-infected subjects were recruited between @date@ and @date@ .
A total of @number@ consecutive patients fulfilled the eligibility criteria and were included in our study ( @number@ patients in each group ) .
A total of @number@ copies were distributed and @number@ copies were valid.
A total of @number@ cranial samples , four from each skull , were collected.
A total of @number@ CVD events occurred during @number@ person-years.
A total of @number@ deaths ( @percent@ ) were related to immunodeficiency after application of the CoDe.
A total of @number@ deaths were reported in weight loss groups and @number@ in non-weight loss groups.
A total of @number@ dental students and @number@ dental hygiene students participated in the intervention-all @number@ of those eligible.
A total of @number@ depressed subjects and @number@ non-depressed community controls were recruited.
A total of @number@ diabetic men died of prostate cancer ( crude mortality rate @number@.9 / 100 , 000 person-years ) .
A total of @number@ differentially expressed proteins out of @number@ confidently identified proteins ( false discovery rate = 0.3% ) were shortlisted for bioinformatics analysis.
A total of @number@ DRP ( median : @number@ DRP / patient ) was found.
A total of @number@ DRPs were found and there was an average of @number@.5±1.3 problems per hospitalization.
A total of @number@ EAS participants contributed @number@ person years of follow-up to the analyses.
A total of @number@ elderly and @number@ young subjects performed in-place hopping in time with a metronome at frequencies of @number@ @number@ and @number@ Hz.
A total of @number@ elderly individuals completed the SF-36 questionnaire.
A total of @number@ elderly men and women aged @number@ years and above , attending a geriatric outpatient clinic.
A total of @number@ elderly participants aged 65-85 years were recruited.
A total of @number@ elderly Taiwanese , aged @number@ and over , completed four survey modules.
A total of @number@ events were observed.
A total of @number@ eyes of @number@ patients were treated by @number@ physicians , with a mean follow-up of @number@ weeks.
A total of @number@ eyes were confirmed as conjunctivochalasis eyes.
A total of @number@ features were extracted from the accelerometric signal recorded during a simple @number@ m walking test at comfort speed.
A total of @number@ fecal samples were collected from yaks in @number@ counties , of which @number@ ( @percent@ ) samples tested positive for Cryptosporidium.
A total of @number@ females were divided into four age groups : young , middle-aged , young-old and old-old.
A total of @number@ genes are associated with these regions of methylation alterations ( promoter or gene body ) .
A total of @number@ genes were modulated in the young group.
A total of @number@ graves were discovered at the early-medieval graveyard near Zadar ( Croatia ) that contained @number@ partially preserved skeletons.
A total of @number@ guttae were counted in @number@ persons from both families.
A total of @number@ gynecologists in five hospitals responded to the survey : Aging Sexual Attitude and Knowledge Scale ( ASKAS ) .
A total of @number@ healthy adult volunteers were included in this study.
A total of @number@ healthy males and females ( age range 15-59 years ) were included.
A total of @number@ healthy , postmenopausal women ( 50-76 years old ) were divided into two groups : control group and exercise group.
A total of @number@ healthy subjects and @number@ patients had adequate image quality for coronary area measurements.
A total of @number@ healthy subjects were recruited and divided into aging and young groups according to chronological age and biological age.
A total of @number@ healthy volunteers between @number@ and @number@ years of age participated in the study.
A total of @number@ healthy women ( aged 18-51 ) were recruited and serum AMH levels were measured for all of them.
A total of @number@ hip fractures were identified , with a mean of @number@ fractures / year.
A total of @number@ Hong Kong Chinese respondents aged between @number@ years and @number@ years were recruited for the study via a random household survey.
A total of @number@ hospital stays were included ( mean age @number@ ± @number@ years ) .
A total of @number@ household members were interviewed and their stool samples analyzed to identify risk factors of FZT infection.
A total of @number@ IgAN patients with different Lee's pathologic grades were enrolled.
A total of @number@ individuals aged @number@ years and older were included in the study , of whom @number@ % were men.
A total of @number@ individuals aged @number@ years or older ( mean age @number@ years ) participated in the study.
A total of @number@ individuals ascertained from a nationally representative cross-sectional health survey served as population controls.
A total of @number@ individuals completed the survey.
A total of @number@ individuals living in community and residential care facilities were included.
A total of @number@ individuals ( @number@ cases and @number@ controls ) aged @number@ years or older were enrolled in the final analyses.
A total of @number@ individuals , @number@ years and older were selected by stratified random cluster sampling.
A total of @number@ individuals ( weighted frequency , @number@ ) aged @number@ and over who completed ophthalmologic and renal functional examinations were evaluated.
A total of @number@ individuals were classified as clinical controls ; @number@ as MCI patients ; and @number@ as having AD dementia.
A total of @number@ individuals were included in the study and followed in @number@
A total of @number@ individuals with at least two offspring aged @number@ years and over were included.
A total of @number@ individuals with MCI and @number@ healthy controls , matched for age and gender , were recruited.
A total of @number@ individuals with presbycusis and @number@ normal-hearing controls were selected based on strict audiometric criteria.
A total of @number@ Japanese participants ( @number@ males and @number@ females ) were chosen for the discovery cohort.
A total of @number@ lesions were treated with cream PUVA using the digital phototherapy device skintrek ( ® ) PT3.
A total of @number@ linear variables and @number@ angular variables were used to clarify the dimensions of the cervical vertebrae.
A total of @number@ literatures were retrieved from Wanfang Data , CNKI and PubMed , and they were all case reports.
A total of @number@ long-term care older adults and @number@ control older adults with independent physical function were included.
A total of @number@ male outpatients attending the Taibah University College of Dentistry ( TUCoD ) dental clinic were included in the study.
A total of @number@ medical teachers received the survey , and @number@ responded.
A total of @number@ men ( age 18-92 years old ) were included.
A total of @number@ men died.
A total of @number@ men formed the study cohort.
A total of @number@ men had complete data on pain status.
A total of @number@ men had PSA between @number@ and @number@ ng / ml.
A total of @number@ Mexican Americans completed the loneliness scale.
A total of @number@ miRNAs were found to be dysregulated in CRC.
A total of @number@ mother-child pairs were included in the present retrospective study.
A total of @number@ MS white matter plaques were identified.
A total of @number@ mutations were identified in @number@ genes.
A total of @number@ mutually exclusive primary AF and @number@ mutually exclusive co-morbid AF events occurred.
A total of @number@ newly diagnosed RA patients were included.
A total of @number@ newly diagnosed type @number@ diabetes mellitus patients during the period from @number@ to @number@ were followed up until @number@
A total of @number@ new substances were also accepted for the FORTA List.
A total of @number@ ( N = @number@ ) married and cohabitating couples completed psychosocial and biomeasure assessments in waves @number@ and @number@
A total of @number@ nonatopic , nonsmoker healthy subjects aged ≥50 years underwent sputum induction and blood cell count.
A total of @number@ normo-ovulatory infertile women scheduled for their first fresh non-donor IVF / ICSI treatment.
A total of @number@ NOTCH3 mutation carriers from a two-center study were investigated using detailed neuropsychological and neuroimaging protocols.
A total of @number@ @number@ patients were included in the analysis.
A total of @number@ @number@ patients were represented in the treatment studies.
A total of @number@ @number@ siblings and @number@ @number@ aunts / uncles were used to investigate the familial aggregation of childhood mortality.
A total of @number@ @number@ smooth muscle actin-positive vascular profiles and @number@ @number@ CD34-positive vascular profiles were evaluated.
A total of @number@ nursing home facilities responded ( @percent@ ) .
A total of @number@ of @number@ consecutive patients evaluated for cognitive status at the Ambulatory Geriatric Clinic had a diagnosis of atrial fibrillation.
A total of @number@ of @number@ delivered questionnaires were completed and returned , yielding a response rate of @percent@.
A total of @number@ of the @number@ distributed surveys were returned ( @percent@ response rate ) ; @number@ analyzed.
A total of @number@ of the @number@ ROIs analyzed showed a significant main effect of the required force-level.
A total of @number@ older adults completed the Spanish version of the Short Form of Health Survey ( SF-8 ) to assess HRQOL.
A total of @number@ older adults comprised the development sample.
A total of @number@ older adults were enrolled.
A total of @number@ older adults were followed up at @number@ months.
A total of @number@ older men and women were recruited to complete the semantic differential scale.
A total of @number@ older people ( 60-80 years ) were surveyed.
A total of @number@ out of @number@ assessments of depressive symptoms in @number@ participants , use of an SSRI was recorded.
A total of @number@ pairs of genotypes were tested and @percent@ were concordant , @percent@ had missing data , and @percent@ were discordant.
A total of @number@ papers were included in this review , most of which were qualitative ( n = 14 ) .
A total of @number@ participants aged ≥40 years were interviewed from @number@ to @number@
A total of @number@ participants aged ≥65 years were included in this retrospective cohort study ; @number@ died during follow-up.
A total of @number@ participants completed the 133-item survey.
A total of @number@ participants developed CVD events during the follow-up period.
A total of @number@ participants died and underwent a uniform neuropathologic examination.
A total of @number@ participants from Spain were included , @number@ aged over @number@
A total of @number@ participants had > 70% young-adult mean bone mineral density at the start of the observation.
A total of @number@ participants in the ENP aged @number@ years or older were interviewed.
A total of @number@ participants ( @number@ male and @number@ female ) completed the survey.
A total of @number@ participants ( @number@ women and @number@ men ) aged older than @number@ y.
A total of @number@ participants over @number@ years old from Spain were included.
A total of @number@ participants responded to the survey.
A total of @number@ participants returned for reassessment.
A total of @number@ participants underwent T1-weighted and high-resolution T2-weighted fluid attenuated inversion recovery magnetic resonance imaging and neuropsychological testing.
A total of @number@ participants were analysed.
A total of @number@ participants were asked questions about their personal definitions of health.
A total of @number@ participants were eligible for analysis.
A total of @number@ participants were enrolled.
A total of @number@ participants were enrolled in the study.
A total of @number@ participants were examined and included in the study.
A total of @number@ participants were included , @number@ of whom worked three or more hours per week.
A total of @number@ participants were recruited for this study.
A total of @number@ participants with normal range of aminotransferase levels and without excessive drinking were included in the present study.
A total of @number@ patents with @number@ internal citation pairs in the US from @number@ to @number@ were analyzed.
A total of @number@ patients aged from @number@ to @number@ years were enrolled.
A total of @number@ patients and @number@ healthy matched controls learned a balance task over a period of @number@ weeks.
A total of @number@ patients met entry criteria.
A total of @number@ patients ( @number@ males ( @number@ % ) ; age range = 44-86 ; mean age = @number@ ) were enrolled.
A total of @number@ patients ( @number@ males , @number@ females ; mean age @number@.05±2.09 years ) were randomly selected for this study.
A total of @number@ patients ( @number@ men and @number@ women ) were evaluated , and volumes of OF and IORF were measured.
A total of @number@ patients ( @number@ ± @number@ years , @percent@ female ) had a follow-up scan after @number@ ± @number@ years.
A total of @number@ patients ( @percent@ ) alive at @number@ months agreed to long-term follow-up.
A total of @number@ patients ( @percent@ ) died in the ward and @number@ patients ( @percent@ ) were discharged.
A total of @number@ patients ( @percent@ ) had cTnThs levels above the @percent@ confidence interval ( CI ) ( cutoff point ) .
Atotal of @number@ patients received end-of-life care at our clinic from October of @number@ to December of @number@
A total of @number@ patients receiving active treatment were dichotomized into younger ( < 60 years ) and older ( ≥60 years ) groups.
A total of @number@ patients replied.
A total of @number@ patients reported @number@ events related to abnormal device parameters.
A total of @number@ patients was analyzed due to a technical sample conservation issue with other samples.
A total of @number@ patients was recruited and followed from the end of @number@ until @date@ .
A total of @number@ patients were divided into two groups with @number@ patients in each group.
A total of @number@ patients were evaluated ; @number@ patients were on anticoagulation and @number@ patients were not.
A total of @number@ patients were examined for PE in this study.
A total of @number@ patients were finally studied ( @number@ men , @number@ women ) .
A total of @number@ patients were hospitalized.
A total of @number@ patients were identified and complete data were available on @number@ patients.
A total of @number@ patients were included.
A total of @number@ patients were treated for hand rejuvenation utilizing this technique and followed up for at least @number@ months.
A total of @number@ patients , which included @number@ patients with AD and @number@ nondemented controls , were recruited.
A total of @number@ patients with a > 15 year history of HIV infection and ART were included , @number@ of whom were suppressed.
A total of @number@ patients with AD , @number@ patients with mild cognitive impairment , and @number@ cognitive intact controls were recruited in the study.
A total of @number@ patients with an average age of @number@ years were included.
A total of @number@ patients with cognitive impairments were included.
A total of @number@ patients with LOH have been treated with TRT using @number@ mg / day of GL for @number@ months.
A total of @number@ patients with severe stages of CKD ( stage @number@ n = 30 ; stage @number@ n = 3 ) were included.
A total of @number@ peaks were evaluated in order to identify useful ion signal candidates using an orthogonal partial analysis.
A total of @number@ people were alive at follow-up ( @number@ @number@ person-years ) .
A total of @number@ people were enrolled in these studies.
A total of @number@ people were enrolled in the study ; @number@ men and @number@ women ( aged 18-90 ) randomly assigned for the study.
A total of @number@ ( @percent@ ) died , including @number@ who had possible or probable AD and @number@ with non-AD dementia.
A total of @number@ ( @percent@ ) HHT patients and @number@ ( @percent@ ) controls passed away during follow-up.
A total of @number@ percent of patients reported between six and @number@ symptoms in the week preceding the survey.
A total of @number@ ( @percent@ ) of the @number@ participants died during the follow-up period.
A total of @number@ ( @percent@ ) participants reported having experienced discrimination and @number@ ( @percent@ ) reported passive response to unfair treatment.
A total of @number@ ( @percent@ ) patients achieved clinical success.
A total of @number@ ( @percent@ ) patients died within this period.
A total of @number@ ( @percent@ ) patients experienced an upstaging in classification of CKD.
A total of @number@ ( @percent@ ) patients had hypogonadism.
A total of @number@ ( @percent@ ) were classified as switchers.
A total of @number@ persons were trained.
A total of @number@ phenotypic measures were screened to determine which were of most value for prediction of long-term ( 19-year ) survival.
A total of @number@ postmenopausal ambulatory Japanese women were followed up for @number@ ± @number@ years ( mean ± SE ) .
A total of @number@ proteins were identified.
A total of @number@ proteins were identified in both wt and HIV / gp120 transgenic mice.
A total of @number@ providers and @number@ stations were associated with these patients.
A total of @number@ publications were identified.
A total of @number@ quarterly visits for asthma was observed.
A total of @number@ questionnaires answered by urologists in high-volume facilities were analyzed.
A total of @number@ questionnaires were returned , including @number@ for test-retest reliability.
A total of @number@ RA patients without known traditional cardiovascular risk factors were selected.
A total of @number@ RBC units were issued in Namibia during the study period.
A total of @number@ records accounting for @number@ blood component units were analyzed.
A total of @number@ records ( @number@ subjects ; age range 30-92 years ) of creatinine clearance and relevant demographic data were used.
A total of @number@ records were analysed.
A total of @number@ relevant medical records was detected.
A total of @number@ relevant studies relating to loneliness interventions were analysed.
A total of @number@ residents and @number@ care providers in an LTCH participated in the feasibility study.
A total of @number@ residents were randomly invited , and @number@ participated.
A total of @number@ responded to both the @number@ and @number@ questionnaires.
A total of @number@ respondents ( between @number@ and @number@ years ) were asked to make hypothetical relocation decisions.
A total of @number@ respondents were interviewed at home in 2008-2010.
A total of @number@ right-eye retinal samples , including those of @number@ ( @percent@ ) women and @number@ ( @percent@ ) men , were selected.
A total of @number@ samples of human cadaveric ligaments removed within 24-48 h after death have been tested.
A total of @number@ screws were removed as a result of revision.
A total of @number@ semi-structured interviews were conducted among elders and caregivers of a Quebec long-term care facility.
A total of @number@ senior adults and @number@ young adults participated in our experiments.
A total of @number@ smokers ( @number@ male and @number@ female , matched for age ) were explored using an Arteriograph in a cross-sectional survey.
A total of @number@ students were evaluated during their rotational clinical posting in the fifth year of the dental education programme.
A total of @number@ studies met inclusion criteria.
A total of @number@ studies , published between @date@ and @date@ , were identified from six databases.
A total of @number@ studies were identified in the systematic search , of which five studies were included in this review.
A total of @number@ studies were included.
A total of @number@ studies were included in this meta-analysis , encompassing a total of @number@ participants ; @number@ young and @number@ older adults.
A total of @number@ subjects aged 40-74 who enrolled in the study in @date@ were asked about dietary and other lifestyle information at baseline.
A total of @number@ subjects belonging to @number@ groups - healthy-young , healthy-elderly and dizzy - were recruited in this study.
A total of @number@ subjects diagnosed clinically as Alzheimer's dementia according to the NIA-AA criteria for AD were included in the study.
A total of @number@ subjects , including @number@ patients with TN , were enrolled in this study.
A total of @number@ subjects ( mean age @number@ years [ range @number@ to @number@ ] ; @percent@ men ) were evaluated retrospectively.
A total of @number@ subjects ( @number@ men and @number@ women ) between the ages of @number@ and @number@ years participated in the study.
A total of @number@ subjects ( @number@ men and @number@ women ) were included.
A total of @number@ subjects ( @percent@ ) reported using ≥5 medications.
A total of @number@ subjects were enrolled for the validation of QCT measurement.
A total of @number@ subjects were evaluated before intervention , after intervention , and at 1-month follow-up.
A total of @number@ subjects were included in the analysis.
A total of @number@ subjects were selected randomly from patients undergoing physical examination.
A total of @number@ subjects who had brain autopsy and comprehensive cognitive testing proximate to death were analyzed.
A total of @number@ subjects with moderate to severe glabellar lines were randomized at a 1 : 1 ratio.
A total of @number@ subjects with Parkinson's disease were enrolled in the study.
A total of @number@ Taiwanese subjects aged over @number@ years from the Taiwan Biobank were analyzed.
A total of @number@ Taiwanese subjects aged over @number@ years from the Taiwan Biobank were analyzed.
A total of @number@ Taiwanese subjects aged over @number@ years from the Taiwan Biobank were analyzed.
A total of @number@ to @number@ U were used to treat the upper third of the face.
A total of @number@ treatment areas were evaluable for long-term follow-up.
A total of @number@ trials have been identified , the clinical data of which have been clearly reported.
A total of @number@ trials were completed and each peripheral target was illuminated in a random block design.
A total of @number@ unique articles were included ; @date@ articles reported BMD including a total of @number@ patients.
A total of @number@ uniquely mapped mRNAs and @number@ miRNAs were commonly expressed and validated in a separate cohort.
A total of @number@ unique variants in the whole 101-kb VDR gene were identified.
A total of @number@ urban elderly individuals aged @number@ years or above in @number@ cities were interviewed.
A total of @number@ valid questionnaires were collected in selected parks in Taipei.
A total of @number@ volatile compounds were found amongst the AMW.
A total of @number@ websites of @number@ e-cigarette manufacturers in China were analysed by using a coding guide which includes @number@ marketing claims.
A total of @number@ women , aged between @number@ and @number@ years , was included.
A total of @number@ women and @number@ men aged 60-96 years were recruited.
A total of @number@ women , @number@ with sarcopenia and @number@ without sarcopenia , were enrolled in the present study.
A total of @number@ women were enrolled.
A total of @number@ women were included.
A total of @number@ women were included.
A total of @number@ women were included in the analysis.
A total of @number@ women with and without osteoporotic fracture seen at the Philippine Orthopedic Center were included.
A total of @number@ women with pelvic organ prolapse , POP-Q stage ≥ @number@ underwent a pelvic floor repair that included Prolift.
A total of @number@ year-9 students were allocated to an intervention or control condition.
A total of @number@ younger and @number@ older adults completed the 22-wk intervention ( from October to March ) with > 85% compliance.
A total of @number@ younger and @number@ older adults were tested in two experiments.
A total of @number@ young women and @number@ AMA women who would undergo IVF were included in this prospective study.
A total of @percent@ considered their current health status as regular.
A total of @percent@ ( n = @number@ ) of the included trials excluded people ages > 65 years.
A total of @percent@ of injuries were due to high-energy impact.
A total of @percent@ of NHs have staff who have received diabetes education or training and @percent@ have access to diabetes care guidelines.
A total of @percent@ of participants reported being comfortable with mobile phones , but comfort was not associated with any cognitive or functional outcomes.
A total of @percent@ of participants were able to use the online tools without assistance.
A total of @percent@ of patients had > or = 1 hospitalization ; @percent@ , > or = 1 ED visit.
A total of @percent@ of the cohort was classified by imaging biomarkers as having MCI with intermediate likelihood of AD according to the NIA-AA criteria.
A total of @percent@ of the patients had at least one chronic comorbidity.
A total of @percent@ of the subjects completed the treatment regime.
A total of @percent@ of the women exhibited considerable / severe menopausal complaints.
A total of @percent@ of the women had primary education , and @percent@ of the women also had one or two children.
A total of @percent@ ( @percent@ CI : @number@.8%-6.2% ) of participants developed all three types of cataract.
A total of @percent@ percent reported that people in their neighborhood would try to take advantage of them if given a chance.
A total of seven articles reporting associations of FOXO3A polymorphisms with longevity were identified and included in this meta-analysis.
A total of seven patients reported silent events and totally eight patients were required to make an unscheduled clinical visit.
A total of seven studies ( @number@ participants ) were eligible in our study.
A total of sixty deficits , including symptoms , disabilities and diseases were recorded through self-report and tests.
A total of sixty one patients with mild to severe nasolabial fold were randomized to receive TheraFill® and KOKEN® on contralateral sides of the face.
A total of some @percent@ of the sample was living with dementia.
A total of ten terminally ill patients were interviewed , along with twenty family members and twenty members of hospice staff.
A total of three olfactory and @number@ neurocognitive tests were administered to @number@ healthy postmenopausal women with varied HRT histories.
A total of @time@ % of samples were suspected of having mental disorders.
A total sample of @number@ fibromyalgia patients and @number@ healthy control women were included in the study.
A total sample of @number@ males and @number@ females aged between @number@ and @number@ years from @number@ European countries was analyzed.
A total symptom score ≥4 allowed the classification of @percent@ of the patients with falls and @percent@ with no falls.
A touch panel screen was used for this test to make it easier.
At our facility , we have been performing abdominal debranching thoracic endovascular aortic repair ( TEVAR ) to resolve these issues.
At P10 and older postnatal ages , an inhomogeneous distribution of Asc among brain regions was detected.
ATP7A relocalization from the trans-Golgi network to the plasma membrane in response to elevated copper concentrations in melanocytes was inhibited by omeprazole.
At passages @number@ @number@ and @number@ analyses were performed to investigate the ploidy , metabolic stability , telomere length and immunophenotype.
ATP ( ATP ) -binding cassette ( ABC ) transporter superfamily members respond to stressors such as hypoxia , cytokine signaling , and aging.
ATP did not alter the osmotic fragility of stored RBCs.
At @percent@ the main direction of loading was towards anteroposterior plane , reflecting elbow flexing forces.
At @percent@ the proportion of immigrants accessing HPC was significantly ( p < 0 , 001 ) below their proportion in the general Berlin population.
At peripheral level it influences adipogenesis and lipogenesis in different tissues including the liver.
At physical rest , there is a net efflux of lactate from the brain into the blood stream.
At physiological levels , Aβ is a normal , soluble product of neuronal metabolism that regulates synaptic function beginning early in life.
ATP-induced PS exposure on RBCs was not dependent on K + , Na + , or Cl- fluxes.
ATP-induced PS exposure was also similar between RBCs stored for less than @number@ week or for @number@ weeks.
ATP-induced PS exposure was similar between RBCs of different densities.
ATP is the product of oxidative phosphorylation whereas O2 ( -• ) is generated by singlet electron reduction of di-oxygen ( O2 ) .
At postnatal day sixteen , abundant AβPP was detected in subiculum and cortical pyramidal neurons.
At preferred walking speed , knee flexion angle at heel-strike and midstance increased with increasing heel height and weight.
At present , animal models play a key role in exploring and screening novel drugs designed to treat ED.
At present , available therapeutics only temporarily relieve PD symptoms.
At present , carotid ultrasound is recommended in diabetic patients with cerebrovascular symptoms.
At present certain conditions are used for the application of these reagents , as determined by trial-and-error investigations , to the effect on fingerprints.
At present , definitive differences are not known between replicative senescence and terminal differentiation.
At present however there is almost no research data supporting this hypothesis.
At present it is known that the degenerative joint disease is of chronic and progressive nature and its pathogenesis is complex.
At present it is not known whether the levels of lactate may differently influence the prognosis of younger and older patients.
At present , it remains unclear what the protective mechanisms that are essential for exercise-induced cardioprotection are.
At present , keloids are classified as strongly inflammatory scars , while hypertrophic scars are considered to be mildly inflammatory scars.
At present , no single indicator could be used as a golden index to estimate aging process.
At present , no treatment nor technique has shown an absolute superiority in terms of efficacy and recurrence rate.
At present @number@ drugs and over @number@ peptide bioregulators are widely used for prevention and treatment of many diseases.
At present , surgery remains the preferred therapeutic choice.
At present , the biochemical finding of T deficiency alone is not sufficient for diagnosing hypogonadism in older men.
At present , the clinical management of varicocele is mainly based on physical examination.
At present , the molecular mechanisms underlying osmotic regulation in IVD cells are poorly understood.
At present , the opinion that oxidative stress is not always harmful , has been accepted.
At present there are neither reliable markers to diagnose AD at an early stage nor therapy.
At present there are no Spanish language instruments for the evaluation of PCC delivered by elderly care services.
At present , there is no consensus or guideline for diagnosis of this deficiency.
At present , there is no convincing evidence that moderate / responsible solarium use increases melanoma risk.
At present , there is no recommendation for mass screening for vitamin B12 in the elderly.
At present , there is no technology for in vivo real-time assessment of collagen structures.
At present , there is no universally accepted therapy for pruritus.
At present , there is still a lack of enough attention to the elderly burn patients.
At present , these Ecl1 family genes , which are extenders of chronological lifespan , have been identified only in fungi groups.
At present the stanley Brain Bank ( @url@ maybe the most preferable choice for psychiatric research in Japan.
At present , very little is known about its regulation.
At present , very little is known about the miRNAs that regulate the expression of BMI1.
At present , we are extending this dataset to acquire comparable phenotypes and genotypes in the biological parents of these individuals.
At pressing , CS wines were more saturated and with a higher red component than control wines.
ATP was maintained whereas creatine increased in the cortex and hippocampus.
ATQ3 activity is dependent upon reversible 2e-redox-cycling.
ATQ3 is orally bioavailable , crosses the blood-brain barrier , and has demonstrated clinical response in inherited mitochondrial disease in open label studies.
A traditional research and drug development paradigm continues to target heterogeneous late-stage clinically phenotyped patients with single ' magic bullet ' drugs.
A trained dermatologist graded the severity of facial skin photoaging from photographs using a global scale.
A trained dermatologist graded the severity of facial skin photoaging from photographs using Larnier's global scale.
A trained interventionist provided hearing screening , communication strategies , and provision of and instruction using a simple over-the-counter amplification device.
A trained panel ( n = 10 ) evaluated sensory quality characteristics including initial and sustained juiciness , aroma and flavour.
A trained researcher administered the FAM-CAM to families and caregivers.
A transgenic mouse model over-expressing Bcl-2 has been shown to rescue neurons from naturally occurring cell death ( NOCD ) .
A transgenic mouse model ( αMHC ( @number@ ) ) has been extensively used to study various mechanistic aspects of HCM.
A transient increase in keratinocyte proliferation , as indicated by staining for Ki67 , was observed.
A transient reactivation of mTOR favored geroconversion in etoposide-treated confluent cells.
A transition program requires more than providing a subsidy.
A translational and multidisciplinary collaborative approach is critical to improve the diagnosis , treatment , and care of patients with IBM.
A Transtheoretical Model ( TTM ) goal-setting tool was used during strength training in women.
A transverse study was carried out with seniors assisted by Family Health teams of the District East Sanitary of Goiania ( GO ) .
A treadmill exercise test was performed using modified Bruce protocol.
A treatment algorithm for acne scarring based on scar morphology and severity is comprehensively outlined.
At recovery , glutathione peroxidase and α -Tocopherol increased significantly above the resting values only in the active group ( p < @number@ ) .
At recovery , no change from resting respiration was seen in either group.
At relapse , the initial treatment may be repeated , if the treatment-free interval exceeds @number@ years.
A tremor score was created based on an approach using hand-drawing samples.
A trend level association was seen between cellularity and HAART duration.
A trend toward a decrease of L1 on the left side , which was more pronounced in the elderly groups , was observed.
A trend towards greater post-procedure erythema and time-to-erythema resolution was observed in the HF group.
A trend toward spinal stiffening with the increasing degeneration has been observed in most studies.
A trend was also observed for increased phosphorus intake and increased number of medications used.
A trend was found for the increased incidence of Marinesco bodies in human substantia nigra neurons with age.
A trend was observed of higher inpatient and total medical expenditure with increasing PISA.
At repeated measures multiple regression adjusted for classical risk factors , opiate dose and duration of opiate use remained significant.
At retrieval , local GMv loss accounted for age-related overactivation of left dorsolateral prefrontal cortex , but not of left dorsomedial prefrontal cortex.
Atrial fibrillation ( AF ) disrupts movement of the left atrium ( LA ) and worsens the vital prognosis by causing thromboembolism.
Atrial fibrillation affects more than @number@ million people worldwide and increases the risk of stroke , heart failure , and death.
Atrial fibrillation affects @number@ million people worldwide and its prevalence is expected to double by @number@ because of the aging population.
Atrial fibrillation ( AFib ) also contributes to CHF development.
Atrial fibrillation ( AF ) is a common and morbid cardiac arrhythmia that increases in prevalence with advancing age.
Atrial fibrillation ( AF ) is an arrhythmia that can occur as the result of numerous different pathophysiological processes in the atria.
Atrial fibrillation ( AF ) is a rhythm disorder with rapidly increasing prevalence due to the aging of the population.
Atrial fibrillation ( AF ) is associated with an increased risk of ischemic stroke or systemic embolism compared with normal sinus rhythm.
Atrial fibrillation ( AF ) is associated with structural , electrical , and contractile remodeling of the atria.
Atrial fibrillation ( AF ) is the most common arrhythmia and a major cause of morbidity and mortality in an aging population.
Atrial fibrillation ( AF ) is the most common cardiac arrhythmia.
Atrial fibrillation ( AF ) is the most common heart rhythm disorder , with increasing prevalence in the aging population.
Atrial fibrillation ( AF ) is the most common heart rhythm problem and a leading cause of morbidity and mortality.
Atrial fibrillation ( AF ) is the most common sustained arrhythmia , and has been further increasing with the aging of society.
Atrial fibrillation ( AF ) is the most common sustained arrhythmia and is associated with stroke , cognitive impairment , and cardiovascular death.
Atrial fibrillation ( AF ) is the most common sustained cardiac arrhythmia.
Atrial fibrillation ( AF ) was the most common transmitted clinical event.
Atrial fibrillation confers a 5-fold higher risk of ischemic stroke compared to sinus rhythm.
Atrial fibrillation confers a 5-fold increase in risk of stroke.
Atrial fibrillation incidence was @number@ per @number@ person-years ( @percent@ confidence interval , @number@ @date@ ) .
Atrial fibrillation is the most common cause of cardioembolic stroke , and anticoagulation is usually recommended.
Atrial fibrillation is the most common sustained cardiac arrhythmia and with an aging population its prevalence will increase.
Atrial fibrillation , the most common chronic cardiac arrhythmia , adversely affects the quality of life of millions of people.
Atrial fibrillation was ascertained from centre visit ECG assessments as well as medical records.
Atrial natriuretic peptide colocalized with PAOs in myocardium , whereas transthyretin was located in the interstitium.
Atrial samples were obtained from @number@ patients , with a mean age of @number@.7±13.8 years.
Atrial tachycardia or AF itself shortens atrial refractoriness and causes loss of atrial contractility.
A tri-axial accelerometer is used to indicate the potential fall as well as to indicate whether the person is in motion.
A triggered sampling study design and an analysis using inverse intensity weights in a GLM offer promise of effectively addressing both shortcomings.
Atrioventricular ( AV ) conduction time ( PR interval ) lengthens with age.
A triple-blind placebo-controlled randomized repeated-measures trial was conducted with @number@ healthy participants , aged 45-77 years.
A triple transgenic mouse model of AD closely resembles human AD neuropathology.
At risk for a category @date@ DDI with nonantiretroviral comedications were @number@ patients ( @percent@ ) .
Atrophic AMD , including early , intermediate and geographic atrophy ( GA ) , accounts for ~90% of all cases.
Atrophic brain areas related to decreases in the three EF components in patients with aMCI were located in the frontal and temporal cortices.
Atrophic facial acne scarring is a widely prevalent condition that can have a negative impact on a patient's quality of life.
Atrophic gastritis also decreases gastric acid production ; however , the role of atrophic gastritis as a related factor for osteoporosis is unclear.
Atrophic phenomena in the organ mucous membrane were accompanied by the destruction of the cells of surface epithelium , crypts and glands.
Atrophic vaginitis is a common finding in women with low estrogen states.
Atrophic volumes were greater in EOAD than in LOAD.
Atrophy can be measured from brain MRI scans , and many technological improvements have been made over the last few years.
Atrophy in the overrecruited regions was modest in comparison with other regions as shown by a between-group voxel-based morphometry comparison.
Atrophy in the right inferior frontal gyrus was most closely associated with a decrease in all three EF components in patients with aMCI.
Atrophy of hippocampus and other basal brain regions is one of the most predominant structural imaging findings related to AD.
Atrophy of the medial temporal lobe ( MTL ) and basal ganglia ( BG ) are characteristic of various neurodegenerative diseases in older people.
Atrophy was also found in a number of subcortical structures , including the CA1 and subiculum subfields of the hippocampus.
Atrophy was not significantly related to serum 25-hydroxyvitamin D by radiologist visual analysis or by the bicaudate ratio.
A truly reliable and fully automated method for quantitative assessment of WMH on magnetic resonance imaging ( MRI ) has not yet been identified.
ATSC-Ex augmented HDF proliferation in a dose-dependent manner and migration ability was enhanced by extract treatment.
At screening they had a moderate ( mean @number@ SD ± @number@ ) WSRS score.
At some point , does one simply become too old to be a father ?
AT stiffness and Young's modulus were measured as the slopes of the tendon's force-elongation and stress-strain curves , respectively.
At study completion , findings will contribute to the emerging literature examining the efficacy of MI in the treatment of pediatric obesity.
At study end , improvements in SPPB score and gait speed were not significantly greater in men receiving cholecalciferol than in those receiving placebo.
At study , subjects viewed objects and concrete words , making @number@ of @number@ different semantic judgments depending on the study material.
At supine rest , no training-induced changes in HR parameters were observed in any of the groups.
At surgery , no additional skin was removed in @number@ percent , and the median amount excised in the remainder was only @number@ mm.
At T1 the men's arches were larger than those of the women.
At T2 ( one year later ) , @number@ of the original @number@ were interviewed and depressive symptom data were available for @number@ sample persons.
At T2 , participants completed weekly diaries of self-reported daily stressors and everyday memory problems for @number@ consecutive weeks.
At T2 , the patients showed a significant improvement of depressive symptoms ( p < @number@ ) , with a not significant increase of MMSE.
Attachment avoidance showed less dramatic age differences overall but was highest among middle-aged adults and lowest among younger and older adults.
Attachment-based theories and related research illustrate that emotion regulation develops in the context of a secure relationship between a child and caregiver.
Attachment security was independently related to life satisfaction.
Attachment style was determined by the Relationship-Specific Attachment Scales for Adults.
Attachment theory in particular provides a common language and conceptual framework from which the contributions from the neurosciences can be made applicable to group psychotherapy.
Attaining optimal glycemic targets in patients with type @number@ diabetes is often hard and compromised by the shortcomings of the several treatments.
Attempts have been made to gain an understanding of the process of IVD degeneration with in Vitro studies.
Attempts to ameliorate cosmetically the appearance of subcutaneous fat loss have been of limited success as they fail to rebuild the missing subcutaneous tissue.
Attempts to ameliorate hormonal declines with exogenous hormonal therapy have produced mixed results.
Attempts to compensate neuronal cell loss by transplantation of dopamine-producing cells started more than @number@ years ago , leading to several clinical trials.
Attempts to intervene in the cascade of events occurring after TBI all rely heavily on the knowledge from basic laboratory investigations.
Attempts to measure intervention integrity were limited and there was usually little or no effort to evaluate intervention effects over a sustained period.
Attempts to resolve their structures were hindered by low solubility and a tendency to aggregation.
Attendance at training on medical or domiciliary dental care for the elderly in need of nursing care had the highest odds ratio.
Attendance to community-based assessment was significantly higher compared with hospital-based assessment in this older population ( p = 0.012 ) .
Attending physician type was determined by Part B physician billing for @percent@ of the billings during that admission.
Attending seminars hosted by the Tokyo Dental Association also significantly influenced implementation of domiciliary dental care.
Attending to provider-patient and provider-provider communication , and to patient social support and self-care needs , could improve integration and care outcomes.
Attending to the origins of success can help gerontologists understand the humanistic tradition behind their inquiry into what successful aging means today.
Attentional biases are known to play a contributing , and perhaps even causal role in the etiology of anxiety and other negative affective states.
Attentional biases to facial expressions of happiness , sadness , fear , anger , and disgust were measured.
Attentional disengagement appeared insensitive to the presence of prodromal dementia or amnestic dysfunction per se.
Attentional processing was defined using three index scores : attentional bias , congruency index , and incongruency index.
Attention has been related to functions of alerting , orienting , and executive control , which are associated with distinct brain networks.
Attention is a complex domain that has reawakened research interest in recent years.
Attention is directed to cultural factors that are both protective and risky for African American women's health.
Attention is drawn to the public and private services , hospitalization patterns , and substantial communication gaps experienced by our moms and families.
Attention measures are considered strongly biologically determined and therefore potentially culture-fair.
Attention-prioritization was examined in Prioritizing Walking ( PW ) and Prioritizing Counting ( PC ) DT conditions.
Attention should be paid to patients on platelet P2Y12 inhibitors , vitamin K inhibitors , and thromboxane A2 inhibitor agents combined with platelet P2Y12 inhibitors.
Attention should be paid to the QRS duration as an indicator of risk for complete AV block in older patients.
Attention should be paid to these factors in the elderly with somatization.
Attention to comorbid conditions in older patients with cancer is warranted considering their impact on SRH in this population.
Attention to different subgroups may be needed to promote participation in specific activities.
Attention to frailty in clinical practice is more likely with better understanding of its prevalence and associations with patient characteristics.
Attention to glycemic control and metabolic care offers a cost-effective method of treatment to reduce complications.
Attention to missing data is particularly important.
Attention to psychosocial issues demands involvement of the patients and their families as partners.
Attention to the level of plasma Hcy may be a viable intervention strategy to prevent decline in spatial navigation in non-demented older adults.
Attention to these differences could contribute to the development of BCIs useful to those with ALS and possibly to others with severe neuromuscular disabilities.
Attention was also found to modulate the strength of the sound-induced flash illusion.
Attention was also paid to the inflammatory status.
Attenuated ACTH recovery in post-menopausal women may have relevance to sex differences in stress-related adaptations.
Attenuation of positive feedback in older compared with younger PMW is consistent with previous reports of declining GnRH responsiveness with aging.
At test costs of €17 per test there was a @percent@ probability that genotyping was cost-effective at €50 @number@ per QALY.
At test , names were presented visually throughout , whereas visual or auditory presentation was used at learning.
At test , participants recreated the route in the forward and reverse directions.
At the 60-69 decade and above , the AARIs was similar in both groups ( ANOVA o.w.
At the 6-month follow-up , the mean Wrinkle Severity Rating Scale ( WSRS ) score change from the baseline for HA was @number@
At the age of @number@ @number@ and @number@ years , the median value was lower by @number@ @number@ and @percent@ , respectively.
At the age of @number@ we measured childhood retinal arteriolar and venular calibers from digitized retinal photographs.
At the age of @number@ years , we measured retinal arteriolar and venular calibers from digitized retinal photographs.
At the Basel Mobility Center , we employ the GAITRite electronic walkway system for spatial-temporal gait analysis.
At the behavioral level , young children made slower and jerkier movements , with less consistent directional planning compared with older children and adults.
At the behavioural level , EE improves learning and memory tasks and reduces anxiety.
At the cellular level , Cisd2 deficiency leads to mitochondrial breakdown and dysfunction accompanied by cell death with autophagic features.
At the cellular level , kinesins UNC-104 / KIF-1A and UNC-116 / kinesin-1 are positive regulators of APL-1 expression in the neurons.
At the College Graduate level , females reported sitting less than males ( p < 0.0001 ) .
At the concentrations tested , only inosine to @number@ mmol / L had effect on platelet P-selectin expression ( p < 0.05 ) .
At the conclusion of the 6-week trial , only the lack of willpower subscale significantly decreased.
At the diaphysis , correlations were ρ = @number@ to @number@ with strong intermethod agreement for most indices.
At the division level , TM / CAM use was significantly related to aging population , employment status , and the number of medical institutions.
At the emotional level , interviewees oscillated between anxiety and strength - having , however , a positive approach to life.
At the end of a follow-up period of @number@ ( 0-24 ) years , the ECG showed AF in @number@ patients ( @percent@ ) .
At the end of follow-up , @percent@ of hip fractured patients had died.
At the end of @number@ seconds it was possible to differentiate normal aging from MCI who no longer differed from the VaD group.
At the end of rehabilitation protocol , a significant improvement of MMSE and RAVLT was observed in the BRRT group as compared to control group.
At the end of the 3-month study , the incidences of renal tubule necrosis were significantly increased in all dosed groups of males and females.
At the end of the ECT course , response rates for the BF and RUL group were @percent@ and @percent@ , respectively.
At the end of the movement , a reference marker appeared and subjects indicated if their hand was left or right of the marker.
At the end of the paper , Appendix @number@ provides algorithms to aid implementation of these new standards in software tools.
At the end of the study , @percent@ of participants had not fallen.
At the end of the study , skin elasticity in both CH dosage groups showed a statistically significant improvement in comparison to placebo.
At the end of the study , topical nifedipine proved statistically effective in reducing the depth of wrinkles.
At the end of the training , a usability and acceptability questionnaire was administered.
At the end of the treatment , skin biopsies were collected from application areas on both forearms.
At the end of this review , we discuss remaining key questions in this area and propose new research approaches. © @number@ American Physiological Society.
At the end of this selection , we obtained a total of @number@ papers ( @number@ studies ) .
At the end of this study , MT treatment resulted to be more effective than standard care to reduce behavioural disorders.
At the end of treatment and @number@ years post-treatment , approximately @percent@ were overweight or obese.
At the end of World War II , a severe 5-mo famine struck the cities in the western part of The Netherlands.
At the end this paper evaluates currently available markers of ovarian reserve and its abilities to be used in routine clinical practice.
At the genetic level , significant associations with AD were found for single nucleotide polymorphisms in TF , TFR2 , ACO1 , and SLC40A1 genes.
At the genetic level , there are polymorphisms that may be driving both extended fertility and longevity.
At the genomic level , the stably hypomethylated CGI cluster tends to be longer and harbors many more CpG dinucleotides than those in other clusters.
At the group level , the MDC95 for the @number@ participants was @number@ points.
At the higher doses used in intervention studies , associations were more evident.
At the higher dose , these effects were more pronounced in middle-aged than in young adults.
At the inclusion , the analytical was made including cystatin C. Falls were recorded for @number@ months after inclusion.
At the individual level , the MDC95 was @number@ points.
At the initiation of intake , level of consciousness , pulse rate , and albumin levels significantly differed between the groups.
At the last evaluation patients completed a specific questionnaire about satisfaction.
At the level of an organism , these changes are initiated by a hormonal response , which in turn activates certain intracellular signaling cascades.
At the level of chromatin , for example , senescence associated heterochromatic foci ( SAHF ) form in some cell types.
At the mechanistic level , KIAA0319 engaged the JAK2-SH2B1 pathway to activate Smad2 , which played a central role in KIAA0319-mediated repression of axon growth.
At the molecular level , COPD and aging share common mechanisms and are associated with significant dysregulation of the immune systems.
At the molecular level , CS is characterized by a deficiency in the transcription-couple DNA repair pathway.
At the molecular level , IRE1 deletion reduced the expression of amyloid precursor protein ( APP ) in cortical and hippocampal areas of AD mice.
At the molecular level , PS-NH2 inhibit , whereas PS-COOH activate mTOR signaling in leukemia cells.
At the moment , genome-wide association studies ( GWAS ) have begun to elucidate the genetic architecture of chronic diseases including , T2DM and AD.
At the moment , @number@ DNA polymerases with striking properties are listed in the eukaryotic cells.
At the moment , studies have shown diverse effects of medications on functional status.
At the mRNA level , tenuigenin resulted in down-regulation of caspase-3 , but up-regulation of tyrosine hydroxylase expression in 6-OHDA damaged cells.
At the neurophysiological level , the prefrontal cortex may engage electrophysiological oscillatory synchronization to coordinate other brain systems during learning.
At the nine-year follow-up , participants were between @number@ and @number@ years of age , still living in their own homes.
At the onset of ophthalmopathy , 80-90% of patients have hyperthyroidism , with the rest having euthyroidism or hypothyroidism.
At the organismal level , comparisons of epigenomes from diverse cell types provide insights into cellular differentiation.
At the pathway level , a decline in ribosomal protein synthesis machinery gene expression with age was detectable in both cell types.
At the @percent@ radius site , trabecular and total volumetric BMD declined with age.
At the point of presentation , baseline characteristics along with a number of disease relevant clinical parameters will be recorded.
At the population level , eveningness appears to have become more prevalent over recent decades.
At the population level , the causes of depression are found in the everyday social and physical environments in which people live.
At the practical level , patients aimed at keeping their diseases under control.
At the present , it is unclear why 5-HT6 receptor agonists and antagonists may facilitate memory or may reverse amnesia in some memory tasks.
At the present time a standardized definition has not yet been established.
At the present time , legal and social systems seem unprepared to handle the phenomenon of dementia in prison.
At the present time , no drug therapies are available for PD-MCI.
At the present time , treatment is supportive.
At the protein level , altered subcellular localization with high cytoplasmic BLM and low nuclear BLM was linked to aggressive phenotypes.
At the recent Aarhus Regenerative Orthopaedics Symposium ( AROS ) @number@ regenerative challenges in an ageing population were discussed by clinicians and basic scientists.
At the regional level , the outcome was defined as the difference between the observed rate of in-hospital deaths and the expected risk-adjusted rate.
At the same concentration , CDA significantly decreased sCD40L levels.
At the same concentrations adenosine inhibited platelet aggregation , decreased the levels of sCD40L and increased intraplatelet cAMP.
At the same time , access to the exact properties of inner face details becomes restricted.
At the same time , an oral glucose tolerance test was administered.
At the same time , a questionnaire was sent to @number@ HAD to find out about their practice on the subject.
At the same time , barriers to a widespread use of these technologies in this population were identified.
At the same time , E2F1-induced Lsh promoter activity is reduced in senescent cells compared to young cells.
At the same time , effective psychotherapeutic interventions can affect brain structure and function and produce lasting positive behavioral changes in aging adults with schizophrenia.
At the same time , elder abuse is independently associated with significant morbidity and premature mortality.
At the same time , energy deficit seems likely to be a natural consequence of the shortage of nutrients.
At the same time , fall incidents often occur among elderly and cause serious injuries affecting their independent living.
At the same time , for some participants , a questionnaire survey and a measurement of the indoor temperature of individual houses were conducted.
At the same time , geriatrics reports the highest level of physician satisfaction among medical specialties.
At the same time , innovations in predictive health offer a pathway to reduce disease burden by preventing and mitigating the development of disease.
At the same time , loading applied to the bone may condition its structure.
At the same time , metabolic abnormalities were detected in one third of non-obese participants with a shift to male gender.
At the same time , new antihypertensive and cardiovascular drugs have been developed , which may preclude revascularization , at least in some cases.
At the same time no ethnic difference in levels of K + was observed regardless of age.
At the same time , observation also had beneficial effects on subsequent action memory , especially in older adults.
At the same time , older women are challenging and resisting these norms , and beginning to renegotiate sexuality in later life.
At the same time , other metabolites , such as triterpenoids and their glycosides , can also be released.
At the same time , reparative activities also decline.
At the same time , seniors also had significantly higher error rates for targets presented in the left vs. right visual field.
At the same time the action of genes which induced in optimal conditions SR differences was partly suppressed under stress conditions.
At the same time , the alternative mechanism of the programmed aging is not developed yet but preconditions for it development have already been created.
At the same time , the decreasing pseudohomophone effect across grades indicates the increasing influence of orthographic knowledge as reading develops.
At the same time , the demands of work usually do not change with age.
At the same time , the differences of @number@ biomarkers were observed in different aging groups in @number@ age groups.
At the same time , the effectiveness of a combination of traditional neuropsychological tests and the VSM was examined.
At the same time , the height and shape of the eyebrows are key points of the periorbital aesthetics.
At the same time , the incidence of autoimmunity in post-menopausal women is decreased or equivalent to the rates observed in similarly-aged men.
At the same time , the inhibited AChE adduct can lose part of the molecule by progressive dealkylation over time in a process called aging.
At the same time , their ERP components differ to some degree from those of controls.
At the same time , the life expectancy of nonagenarians with CLI is limited to approximately @number@ years , irrespective of the method of treatment.
At the same time , the microvesiculation and haemolysis started to rise exponentially.
At the same time , the participation of IL-6 / IL-8 ratio was determined.
At the same time , there was no plasticity reduction in older individuals within the task tested.
At the same time , these results raise methodological issues with regard to different modalities in which emotion decoding is measured.
At the same time , the VSM correlates with various established neuropsychological tests.
At the same time , they must respond rapidly to acute needs such as infection or injury.
At the same time , they were impacted on by social and cultural factors.
At the same time vitamin D suppresses the expression of myostatin , a negative regulator of muscle mass.
At the same time , we noted a higher incidence of ischemic heart disease ( @percent@ vs @percent@ ) .
At the same time , WM training studies have shown that some older adults are able to increase their WM performance through training.
At the same time , young genes are most likely to be medically relevant.
At these conditions , the competitive side hydrolysis of VFA was @number@.7-fold minimized.
At these loci , replication stress frequently activates DNA repair synthesis in mitosis.
At these same time points , hTau mice also exhibited altered MAPT phosphorylation with neurogenic precursors.
At these same times , tolerant patients underwent functional magnetic resonance imaging ( fMRI ) while performing structured motor and cognitive tasks.
At these sites , mild hyperopia was the most prevalent category during early childhood , and myopia became the predominant category later.
At these three loci , as well as at GRP20 / CDH17 , associated variants had alleles common only in African-ancestry populations.
At these wavelengths , absorption by superficial water containing tissue is relatively weak , thereby effecting deeper tissue penetration.
At the stage of CDR @number@ all tools showed high positive percentages.
At the start of the 21st century , the human genome project provided the scientific community with an enormous array of information as genetic blueprints.
At the systemic level , Mt decreases hormonal production , stimulates immune activity , and prevents the development of metabolic syndrome.
At the time of Marketing Authorisation ( MA ) these criteria are reassessed to ensure they are still met.
At the time of myelination , the oligodendrocytes that synthesize myelin require a large amount of energy for this task.
At the time of puberty , AMH concentrations declined and remained relatively stable throughout adulthood.
At the time of surgery abdominal subcutaneous adipose tissue from adjacent sites was removed by excision and needle aspiration.
At the time of the observations , measles virus circulation was virtually eliminated , whereas parvovirus B19 circulated at lower levels than VZV.
At the trial's end , patients shared their final evaluation and perception of results with a questionnaire.
At the ultrastructural level it has been shown by the example of prostatitis and skin aging changes.
At this concentration , formula @number@ also induced collagen expression and inhibited matrix metalloproteinase-1 expression at the transcriptional level.
At this juncture , conclusions should be tentative.
At this period , BBB leakage is likely to be an important factor in edema formation.
At this point in the disease , amyloid plaques are also abundantly distributed in the cortex.
At this point in time it remains unclear to which extent additional factors determine the development of glaucoma.
At this point in time the role for determining ageing and its use as a prognostic tool seems to be impossible.
At this point , participants were asked to attempt to retrieve the stick.
At this point , the values reached a nadir for both genders.
At this stage , intervention to reverse functional losses is often too late.
At this time , hyaluronidase is used off-label for correction.
At this time , the best prescription for lifestyle interventions for healthy cognitive aging would be sustained physical , social , and mental activities.
At this writing , the longest follow-up period has been @number@ years , with the patient still maintaining periorbital volume.
At three months , all fixations were judged as satisfactory or better.
At three-year follow-up , in men , no significant prospective associations were detected.
At three-year follow-up , @percent@ had incident MC.
At times caregivers looked on the bright side and made downward comparisons.
Attitudes and person-centred strategies each uniquely explained a moderate amount of variance , while training and knowledge were not significant predictors of sense of competence.
Attitudes of dental students regarding the provision of treatment tend to be dentist-centered ; however , facilitating mixed student group formation could change such perceptions.
Attitudes regarding personal aging were similar among the professions.
Attitudes toward sexuality and aging may be more strongly tied to demographic variables reflective of religious beliefs or adherence to sociocultural norms.
Attitudes towards help seeking behaviours in older people remain a largely unexplored field of research.
Attitudes towards the use of pain medications differ widely , and lack of efficacy or fear of side effects may lead to sub-therapeutic dosing.
Attractor searches are performed in parallel to the modeling process.
Attribution of these changes to pubertal status rather than age has important implications for our understanding of the neurobiology of anxiety and affect regulation.
Attrition and wear of tooth surface occur with aging and result in loss of enamel , with exposure and histological changes in dentin.
Attrition is one of the most important threats for longitudinal studies on aging mainly due to refusal and mortality.
Attrition of telomere length in peripheral blood mononuclear cells ( PBMCs ) with age is well documented from cross-sectional studies.
At TSGs , CHD4 retention helps maintain DNA transcriptional silencing.
Attuning the steps to the cues is attentionally demanding.
At two loci ( JAK2 and A1CF ) , experimental analysis in mice showed lipid changes consistent with the human data.
A tuberculose compreendeu @percent@ das infecções definidoras de imunodeficiência.
A turning point occurred when the epigenetic signature of DNA methylation was observed to gradually change during an individual´s lifespan.
At VT3 , @number@ participants had MCI , @number@ participants had AD , and @number@ were in good health.
At wave @number@ participants self-reported fruit and vegetable intake ( FVI ) and completed the Yale Physical Activity Scale.
At Week @number@ all doses of RT002 were highly effective at maximum frown.
At week @number@ a market facial volume restoration was shown and no adverse events were reported.
At week @number@ the disease control rate was @percent@.
A twin modeling approach was used to estimate genetic and environmental contributions for time-specific and average DHEAS concentrations.
A two-alternative forced-choice paradigm combined with an adaptive algorithm to define stimulus magnitude was used.
A two-alternative forced choice procedure was used in discriminating the orientation of Gabor patches.
A two-day meeting was attended by @number@ individuals.
A two-dimensional difference in-gel electrophoresis analysis was performed on the Msr-silenced cells grown under basal conditions or submitted to oxidative stress.
A two-phase data collection design was used.
A two-sample t test estimated the association between frusemide use and thiamin concentration and regression between thiamin concentration and EGFR.
A two-site ELISA for oligomers was developed using @number@ coupled to a sensitive , bead-based fluorescent platform able to detect single photons of emitted light.
A two-stage method is used in the estimation.
A two-stage stratified clustering sampling method was performed , and @number@ female participants aged ⩾60 years were included in the analysis.
A two-step process adjustment was followed to identify the most appropriate covariance structure for each HC-QI.
A two-step process was developed to incorporate vitamin E into irradiated UHMWPE by diffusion to obtain a uniform concentration profile.
A two-tailed p value < 0.05 was considered significant ( @percent@ CI ) .
A two-way analysis of variance ANOVA was also conducted to test the interaction between gender and seasonal birth date with regard to performance.
A two-way repeated-measures ANOVA shows a time × group significant interaction effects.
At year @number@ only the FM change was significantly different between groups.
At year @number@ @percent@ of blacks used an anticholinergic medication compared with @percent@ of whites , and this difference persisted over the ensuing 10-year period.
At young age results of the relative parameters are higher for women , whereas absolute parameters are higher for men.
At young ages senescence rates were negative , while senescence rates declined at old ages.
At younger ages , males were shown to have a higher risk for stroke than females.
A-type lamins are components of the lamina network at the nuclear envelope , which mediates nuclear stiffness and anchors chromatin to the nuclear periphery.
A-type lamins , key structural components of the nucleus , have been implicated in the maintenance of nuclear architecture and chromatin structure.
A-type lamins provide a scaffold for tethering chromatin and protein complexes regulating nuclear structure and function.
A-type lamins , the intermediate filament proteins participating in nuclear structure and function , are encoded by LMNA.
A typical developmental decrease of low-frequency EEG power was observed even at this late stage of brain maturation.
A typical example noted in experimental environments is the interpersonal synchronization of body movements such as nods and gestures during smooth face-to-face communication.
A typical Snellen's chart ( the direction of the gap in Landolt C ) was used for noncorrected and best-corrected visual acuity testing.
AUD did not significantly modulate the rate of susceptibility increase with age in our data.
Audiological testing included preoperative and postoperative pure-tone audiometry and a monosyllabic word recognition test presented from recorded material in free field.
Audiometry was also conducted.
Auditory abilities were measured with pure-tone audiometry , speech-in-noise perception , and discrimination thresholds for both static and dynamic spectral patterns.
Auditory attention has been shown to modulate medial olivocochlear ( MOC ) efferent activity in human adults.
Auditory brainstem responses ( ABRs ) were recorded pre- and post injection time points to assess hearing loss.
Auditory deprivation and the restoration of hearing via a cochlear implant ( CI ) can induce functional plasticity in auditory cortical areas.
Auditory evoked fields were successfully measured from all seven children and dipole source locations were computed.
Auditory novelty processing and habituation of the novelty P3 event-related potential were investigated in younger and older adults.
Auditory processing deficits in ASD may be indicative of an association with the sensory abnormalities and social and communication impairments characterizing the disorder.
Auditory-visual ( AV ) synesthesia is a rare phenomenon in which an auditory stimulus induces a \ "concurrent \ " color sensation.
Audits also collected the name , route , and duration of the associated antibiotic.
Augmentation index significantly increased after exercise only in the YG ( @number@ ± @percent@ , p < @number@ ) .
Augmentation is a common complication , with prevalence rates of nearly @percent@ , and is a common cause of treatment failure.
Augmentation with ADM provides a simple , easy , and minimally invasive option for the treatment of deep glabellar wrinkles.
Augmentation with an antidepressant medication can be helpful for the elderly patient with schizophrenia and depressive symptoms.
Augmented cortical activity during repetitive grasping mitigates repetition-related decrease in cortical efficiency in young adults.
Augmenting such interventions with a focus on attachment experiences may reduce perceived stress , an important health risk factor.
A UK-based economic model explored treatment costs with ISAV versus liposomal AMB followed by posaconazole.
A UK blood service control sample showed a duplication CNV that overlapped PRNP , but these were not found in prion disease.
A unidirectional flow of synovial fluid has been identified in this region.
A unique assembly of experts from around the globe , compiled and edited this manuscript based on a thorough literature review and personal experience.
A univariate analysis and a multiple regression analysis were then performed to identify the influencing factors.
A univariate analysis assessed in a stepwise multiple regression model was conducted.
A univariate analysis found some associations between demographic and clinical characteristics and quality of life.
A universal method for reproducibly directing stem cell differentiation remains a major challenge for clinical applications involving cell-based therapies.
Aural rehabilitation has long been advocated to enhance communication but has not been considered time or cost-effective.
A urine specimen for culture should be obtained from patients with symptomatic infection prior to institution of antimicrobial therapy.
A usability and acceptability questionnaire was administered at the end of training.
A useful approach to independently predicting CVD is brachial-ankle pulse wave velocity ( baPWV ) .
A user-friendly web application provides access to the stored data.
Australia has an ever increasing ageing population due to advances in healthcare and post-war booms in fertility.
Australian health-care providers should consider the OWL protocol as a simple method to reduce the risk from alcohol consumption among older adults.
Australia's aging society will face special challenges that demand current attention.
Author analyses the special medical and social concerns of severe states of Alzheimer disease.
AUTHORS ' CONCLUSIONS : Finasteride improves long-term urinary symptoms versus placebo , but is less effective than doxazosin.
AUTHORS ' CONCLUSIONS : There is evidence that CGA can improve outcomes in people with hip fracture.
Authors discuss integrating interdisciplinary depression care in the home care setting.
Authors have no competing interests to disclose.
Authors provide results of their review of research in the field of biogerontology.
Autism is a lifelong neurodevelopmental disorder , with a known impact on quality of life.
Autism spectrum disorder ( ASD ) is a highly heritable neurodevelopmental disorders characterized by impaired social interactions , communication deficits , and repetitive behavior.
Autoantibodies against coagulation factors can develop in patients associated with autoimmune disorders , malignancies , pregnancy , and drug-induced or dermatological diseases.
Autoantibody biomarkers were also useful in distinguishing subjects with the relapsing-remitting form of MS from those with the secondary progressive subtype.
Autobiographical generation was analyzed with respect to theme , general autobiographical performance , contextual performance , self-defining memories , and autonoetic reliving / re-experiencing.
Autobiographical memories are disproportionately recalled for events in late adolescence and early adulthood , a phenomenon called the reminiscence bump.
Autobiographical memories of older adults show fewer episodic and more non-episodic elements than those of younger adults.
Autofluorescence topography differs distinctly from the topography of age-related rod loss.
Autogenous dermis , autogenous fat , autogenous dermis-fat , allogenic dermis , synthetic implants , and fillers have been widely accepted for soft tissue augmentations.
Autogenous fistulas and in particular radiocephalic fistulas are recommended as the first vascular access for hemodialysis.
Autografts have excellent biological properties but are associated with morbidity of the donor site and are restricted in volume.
Autoimmune cytopenia is a frequent manifestation of primary immunodeficiencies.
Autoimmune thyroid diseases ( AITD ) are common , affecting 2-5% of the general population.
Autoimmunity did not differ but interaction of autoimmunity with FMR1 genotype almost reached significance ( P = @number@ ) .
Autologous bone grafting represents the standard of care for treating bone defects but this biomaterial is unreliable in older patients.
Autologous bone marrow mononuclear cells were collected and injected locally into the bowel mucosa , and subsequently injected systemically through a peripheral vein.
Autologous fat grafting is a challenging procedure , due to the fragile characteristic of adipose tissue.
Autologous fat grafting is now a commonly performed aesthetic procedure.
Autologous human keratinocytes ( HK ) forming sheet grafts are approved as skin substitutes.
Autologous skeletal muscle precursor cells ( skMPCs , @number@ million ) were injected into the urinary sphincter @number@ weeks after a surgically induced ISD procedure.
Automated brain segmentation was used to quantify intracranial volume , and volumes of total brain , sulcal cerebrospinal fluid , and ventricles.
Automated calculation of whole-brain volume is presented to demonstrate use of the data for measuring differences associated with normal aging and Alzheimer's disease.
Automated dispensing could lead to perpetual repeating of drug therapies without the necessary re-evaluation.
Automated image analysis software was developed to evaluate the fractal dimension D , using the mass radius method.
Automated image processing included an intra-subject registration of all time points and an inter-subjects registration to a brain atlas.
Automated segmentation with manual correction was used to derive retinal thickness values.
Automated tools that can detect WMHs robustly and with high accuracy are needed.
Automatic and expert manual brain volumes were compared.
Automatic system-transmitted events by HM and related clinical information were recorded and consulted by well-trained physicians.
Automation of IF analysis can transform studies using experimental cell models.
Autonoetic consciousness was not associated with AD biomarkers , and was not impaired in MCI.
Autonomic control of heart rate is mediated by cardioinhibitory parasympathetic cholinergic neurons located in the brainstem and stimulatory sympathetic noradrenergic neurons.
Autonomic cotransmission offers subtle , local variation in physiological control mechanisms , rather than the dominance of inflexible central control mechanisms envisaged earlier.
Autonomic dysfunction is common in HIV.
Autonomic function was assessed by means of @number@ standard cardiovascular reflex tests.
Autonomic function was assessed by spectral analysis of heart-rate variability ( HRV ) while fasting and after a meal.
Autonomic imbalance , characterized by a hyperactive sympathetic system and a hypoactive parasympathetic system , is associated with various pathological conditions.
Autonomic modulation was evaluated by spectral analysis of HR variability ( HRV ) .
Autonomic nervous system ( ANS ) activity may play an important role in the development of lower urinary tract symptoms ( LUTS ) .
Autonomic neuropathy was defined using a laboratory-based autonomic assessment , the Composite Autonomic Severity Score ( CASS ) .
Autonomous downregulation of the mitogen-activated protein kinase ( MAPK ) signaling pathway was identified as confirmed by western blotting and qPCR.
Autonomous patients aged @number@ or more using @number@ or more medicines and under follow-up in the pharmacy were invited to participate.
Autophagic activity declines with age and may explain many features of age-related cardiac dysfunction.
Autophagic cells were observed in cartilage obtained from osteoarthritis ( OA ) model rats and human OA patients.
Autophagic dysregulation has been suggested in a broad range of neurodegenerative diseases including age-related macular degeneration ( AMD ) .
Autophagic mechanisms are cellular digestion processes that recycle cellular components and contribute to protein homeostasis.
Autophagosomes containing Aβ failed to fuse with lysosomes in HSV-1-infected cells , indicating the impaired degradation of Aβ localized in the autophagic vesicles.
Autophagy , a cellular housekeeping process , is essential to maintain tissue homeostasis , particularly in long-lived cells such as cardiomyocytes.
Autophagy , a central pathway for cellular homeostasis , plays diverse roles in development , cancer , aging , and neurodegeneration.
Autophagy , a conserved lysosomal , self-destructive process involved in protein and organelle degradation , plays an essential role in both cellular and whole-animal homeostasis.
Autophagy activation , as reflected by LC3-II , was decreased in a time-dependent manner.
Autophagy activation significantly protected against mitochondrial dysfunction.
Autophagy , a degradation mechanism that plays a major role in maintaining cellular homeostasis and diminishes in aging , is considered an aging characteristic.
Autophagy also plays an essential role in cellular homeostasis in kidney and counteracts age-related stress and kidney diseases.
Autophagy and ubiquitin-proteasome system ( UPS ) are the conserved intracellular degradation processes of eukaryotic cells.
Autophagy and ubiquitin proteasome system ( UPS ) provides regular cytoprotection against proteotoxicity induced by abnormal or disruptive proteins.
Autophagy , apoptosis and intracellular level of IL-4 , IL-10 , and IL-13 were determined using flow cytometry analyses.
Autophagy assists tissue homeostasis by forming a pathway by which these substances are degraded.
Autophagy contributes thus to modulating the amount of cellular lipids and allows cells to adapt to lipogenic stimuli.
Autophagy contributes to anti-aging , antimicrobial defense , and tumor suppression.
Autophagy degrades pathogens , altered organelles and protein aggregates , and is characterized by the sequestration of cytoplasmic cargos within double-membrane-limited vesicles called autophagosomes.
Autophagy delivers cytoplasmic components and organelles to lysosomes for degradation.
Autophagy diminishes with aging ; additionally , accelerated aging can be attributed to reduced autophagy.
Autophagy dysregulation is implicated in the pathogenesis of multiple diseases , such as aging , cancers , diabetes.
Autophagy has a pivotal role in recycling these damaged non-functional organelles and misfolded or unfolded proteins.
Autophagy induction and p21 upregulation were also repressed by knockdown of Beclin1.
Autophagy induction is part of the endogenous response to poly-Q protein expression.
Autophagy inhibitors bafilomycin A1 , ammonium chloride , and 3-methyladenine failed to increase ubiquitinated protein levels.
Autophagy involves more than @number@ proteins and is regulated by nutrient availability , and various stress sensing signaling pathways.
Autophagy is a catabolic degradation system used to destroy and recycle the unnecessary or damaged components of a cell.
Autophagy is a catabolic membrane-trafficking process that occurs in all eukaryotic organisms analyzed to date.
Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular components.
Autophagy is a catabolic process that delivers cytoplasmic material to the lysosomes for degradation.
Autophagy is a cellular homeostatic process whereby damaged proteins and organelles are encapsulated into double membrane vesicles , called autophagosomes , for lysosomal digestion.
Autophagy is a cellular mechanism implicated in the pathology of Parkinson's disease.
Autophagy is a cellular process responsible for the degradation of intracellular cargo.
Autophagy is a cellular recycling program that retards ageing by efficiently eliminating damaged and potentially harmful organelles and intracellular protein aggregates.
Autophagy is a conserved cellular degradation pathway for the breakdown of cytosolic macromolecules and organelles.
Autophagy is a conserved cellular process that plays an important role in cardiovascular homeostasis.
Autophagy is a conserved cellular self-digestion pathway for maintenance of homeostasis under basal and stressed conditions.
Autophagy is a critical pathway for the degradation of intracellular components by lysosomes.
Autophagy is activated following an ischemic insult or preconditioning , but it may exert dual roles in cell death or survival during these two processes.
Autophagy is active in the heart at baseline and further stimulated under stress conditions including starvation , ischemia / reperfusion , and heart failure.
Autophagy is a dynamic pathway involving the formation of a membrane surrounding and enclosing cargoes that are delivered to lysosomal compartments for degradation.
Autophagy is a fundamental biologic process that fulfills general and specialized roles in cytoplasmic homeostasis.
Autophagy is a highly conserved and regulated intracellular lysosomal degradation pathway that is essential for cell survival.
Autophagy is a highly conserved catabolic process involved in the degradation of long-lived proteins , damaged organelles , and subcellular structures.
Autophagy is a highly conserved degradative process through which cells overcome stressful conditions.
Autophagy is a homeostatic mechanism for cellular quality control through the disposal and recycling of cellular components.
Autophagy is a key mechanism for the maintenance of intracellular and organismal homeostasis.
Autophagy is also involved in a variety of biological functions like development , cellular differentiation , defense against pathogens and nutritional starvation.
Autophagy is also responsive to stress and can degrade damaged proteins and organelles , oxidized lipids and intracellular pathogens.
Autophagy is a lysosome-dependent catabolic process involving in the degradation and recycling of unnecessary or damaged proteins and organelles.
Autophagy is a lysosome-mediated catabolic pathway classified into three different types : macroautophagy , microautophagy , and chaperone-mediated autophagy.
Autophagy is a major clearance mechanism that degrades organelles and large protein aggregates to maintain cell survival and protein homeostasis.
Autophagy is an essential homeostatic process for degrading cellular cargo.
Autophagy is an evolutionarily conserved and lysosome-dependent process for degrading and recycling cellular constituents.
Autophagy is an evolutionarily conserved process by which long-lived proteins and organelles are sequestered by autophagosomes and subsequently degraded by lysosomes for recycling.
Autophagy is an evolutionarily conserved process essential for cellular homeostasis and organismal viability.
Autophagy is an intracellular degradative system that is believed to be involved in the aging process.
Autophagy is a predominant cytoprotective ( rather than self-destructive ) process.
Autophagy is a process of lysosomal self-degradation that maintains a homeostatic balance between the synthesis , degradation , and recycling of cellular proteins.
Autophagy is a process of lysosome-dependent intracellular degradation that participates in the liberation of resources including amino acids and energy to maintain homoeostasis.
Autophagy is a process preserving the balance between synthesis , degradation and recycling of cellular components and is therefore essential for neuronal survival and function.
Autophagy is a reparative , life-sustaining process by which cytoplasmic components are sequestered in double-membrane vesicles and degraded on fusion with lysosomal compartments.
Autophagy is a self-regulated cell process , the peak of autophagy is followed by its regulatory weakening by amino acids formed in autophagolysosomes.
Autophagy is concomitantly up-regulated , suggesting that mitochondria are degraded via mitophagy.
Autophagy is dynamically regulated in the heart in the fasting to re-feeding transition.
Autophagy is emerging as a core regulator of Central Nervous System ( CNS ) aging and neurodegeneration.
Autophagy is essential to neuronal homeostasis , and its impairment is implicated in the development of neurodegenerative pathology.
Autophagy is important for maintaining cardiac homeostasis and is a survival mechanism that is upregulated during stress or starvation.
Autophagy is important within the nervous system , but its function in specific compartments such as the synapse has been unclear.
Autophagy is increased in many long-lived model organisms and contributes significantly to their longevity.
Autophagy is integral in mitochondrial quality control and lipid homeostasis in the liver.
Autophagy is potentially implicated in acute lung injury and sepsis , two main causes of morbidity and mortality worldwide.
Autophagy is present at a basal level in all mammals and is regulated by some conditions , such as oxidative stress , starvation or hypoxia.
Autophagy is probably a crucial and a major process in the preservation of brain integrity.
Autophagy is strongly activated in the heart during reperfusion after ischemia.
Autophagy is well identified to act as either as a tumor-suppressor or as a tumor-promoter in ovarian carcinoma.
Autophagy-lysosomal degradation of Htt aggregates may protect the neurons in HD.
Autophagy maintains cellular homeostasis by sequestering unwanted material within autophagosomes and transferring these to lysosomes for degradation.
Autophagy maintains cellular homeostasis during stressful conditions , dampens inflammation and shapes adaptive immunity.
Autophagy may also maintain cell function by removing protein aggregates or damaged mitochondria.
Autophagy may be both adaptive and beneficial for cell survival , or maladaptive and detrimental for the cell.
Autophagy / mitophagy markers were positively correlated with the 6-minute walk and leg lean mass ( p < @number@ ) .
Autophagy modulates these critical functions of the endothelium in a dynamic and perpetual response to tissue and intravascular cues.
Autophagy occurs in all cells and tissues , and it is regulated by the Atg genes.
Autophagy participates in the oxidative stress response in many cells , which plays a protective role in preventing damage caused by oxidative stress.
Autophagy plays pivotal roles in the pathogenesis of many diseases , such as aging-related diseases , autoimmune diseases , cardiovascular diseases , and cancers.
Autophagy regulation is dependent of cell metabolic status and consequently on the @number@'AMP-activated protein kinase ( AMPK ) and mammalian target of rapamycin signaling pathways.
Autophagy ( \ "self-eating \ " ) constitutes one of the most spectacular yet subtly regulated phenomena in cell biology.
Autophagy then interacts with apoptotic and necrotic signaling pathways to regulate cell death.
Autophagy was also investigated since DOX treatment was able to induce cells entering senescence and eventually lead to cell death.
Autophagy was known to be associated with aging in addition to cancer and neurodegeneration.
Auto polymerizing cements become more opaque with aging ; therefore , porcelain restorations may lose their match with other teeth.
Autopsies were performed on @number@ participants who died , and β-amyloid ( Aβ ) and neurofibrillary tangles were identified by immunohistochemistry and quantified.
Autopsy data from @number@ participants in the Honolulu-Asia Aging Study ( HAAS ) were combined into latent factor measures of NFT and NP counts.
Autopsy revealed proliferation of large atypical cells with clear and irregular nuclei in the brain tissue.
Autoregulation is a vital homeostatic mechanism that helps maintain constant delivery of oxygen to organs despite fluctuations in arteriolar pressure.
Auto-SCT-related mortality was @percent@ ( n = 4 / 104 ) in younger and @percent@ ( n = 3 / 82 ) in older patients.
Autosomal dominant Alzheimer's disease mutation carrier individuals have elevated PiB levels in nearly every cortical region @number@ y before the estimated age of onset.
Autosomal dominant familial Alzheimer's disease accounts for @percent@ of all Alzheimer's disease.
Autosomal-dominant missense mutations in LRRK2 ( leucine-rich repeat kinase @number@ ) are a common genetic cause of PD ( Parkinson's disease ) .
Autosomal dominant mutations in BACKGROUND : Studies have documented gender differences associated with concussion.
Autosomal-dominant polycystic kidney disease ( ADPKD ) is the most common hereditary and systemic disorder associated with various cardiovascular complications.
Autosomal recessive primary microcephaly ( MCPH ) is characterized by a substantial reduction in brain size but with normal architecture.
Autotaxin may be a novel biomarker of dysmetabolism and AD.
Auxology ( Greek αυξω - I let grow ) is the science of human growth and development.
Availability and Implementation : fastMitoCalc is available at @url@
AVAILABILITY AND IMPLEMENTATION : Software executables are available upon request.
AVAILABILITY AND IMPLEMENTATION : The Perl and R scripts are available at @url@
Availability and Implementation : The SIPI software is freely available at @url@ .
Availability and Implementation : ViSiBooL ( Java @number@ ) is freely available at @url@ .
Availability of assistive devices in the workplace decreases the likelihood of receiving disability benefits , whereas informing an employer about hearing problems increases this likelihood.
Availability of resources may be reflected by socioeconomic indicators , such as parental education and family size.
Available automatic scoring programs will incorporate all the new rules so that the new standards should reduce technician burden for scoring PLMS.
Available clinical tools usually do not include patients ' self-perceived risk of falling.
Available data on biological drugs in the elderly are limited.
Available data were compared in patients with and without long QT syndrome.
Available fine-needle aspiration cytology smears were cellular and exhibited many loosely cohesive syncytial clusters or isolated cells.
Available options in the United States have expanded from autologous tissues and animal-derived collagens to bacterially fermented biopolymers and synthetic implants.
Available studies showed a beneficial impact of cessation of psychotropic drugs on falls and cognitive status.
Available trial results suggest equivocal improvements in sexual function.
A validated 5-point wrinkle scale and a 9-point global improvement scale were used to measure line severity.
A validated instrument was used to measure well-being and happiness [ Oxford Happiness Inventory ( OHI ) ] .
A validated LC-MS / MS method was developed for the determination of d -Serine in human plasma.
A validated , multi-pass , 24-h recall dietary assessment , administered by NHANES , was employed to quantify consumption of nuts and seeds.
A validated new histological classification for intervertebral disc degeneration.
A validated screening instrument that can provide a systematic assessment of risk factors can facilitate this detection.
A validation group ( n = @number@ ) had clinical and laboratory parameters intermediate to the control ( n = @number@ ) and osteoporosis groups.
A validation study using cohort data found biological age to be a superior index for disease-related mortality than chronological age.
A valid , time-efficient and easy-to-use instrument is important for busy clinical settings , large scale surveys , or community screening use.
A value of @number@ kg / m ( @number@ ) or lower can be considered a useful trigger for nutritional support.
Avanafil is rapidly absorbed after oral administration , with a median time to maximum plasma concentration of @number@ to @number@ min.
Avanafil ( STENDRA™ , SPEDRA™ , Zepeeed™ ) is an oral phosphodiesterase type @number@ inhibitor indicated for the treatment of erectile dysfunction.
Avanafil was generally well tolerated in the above-mentioned studies.
A variant of bipolar delivery is fractional RF delivery.
A variation in regional structural stiffness of human aorta was observed.
A variation located at the @number@ UTR of the GRM4 gene may influence the interaction between miR-1202 and GRM4.
A variation of the superficial musculoaponeurotic system ( SMAS ) plication called SPA face lift is here described.
A variável dependente foi a fonte de ajuda , categorizada como exclusivamente informal ( não remunerada ) , exclusivamente remunerada , mista ou nenhuma.
A variável independente foi o número de medicamentos de uso crônico por idosos , vinculados às oito doenças crônicas investigadas.
A variety of alternatives are available for facial skeletal and soft tissue volume enhancement.
A variety of caregiver outcomes was measured after @number@ and @number@ months.
A variety of chronic pathologies often come along with the aging process and are experienced by many patients in late adulthood.
A variety of different evaluation methods have been developed to measure both objective and subjective parameters of the condition.
A variety of endogenous and exogenous agents can induce DNA damage and lead to genomic instability.
A variety of fascinating morphological patterns arise on surfaces of growing , developing or aging tissues , organs and microorganism colonies.
A variety of hormones regulate growth , development and metabolism throughout the lifespan.
A variety of mechanisms may be responsible for the development of bone loss in patients with breast or prostate cancer.
A variety of miRs have been implicated in the development of vascular calcification , whereas others appear to play a protective role.
A variety of models for registries exist , but few data are available to instruct their design and implementation.
A variety of nicotinaldehyde derivatives were synthesized and evaluated as inhibitors in kinetic assays.
A variety of ongoing research has tried to employ small RNAs-small interference RNA and microRNA as new cosmeceutical ingredients.
A variety of phytomolecules , derived in particular from polyphenols , triterpenes and sterols classes , demonstrated a promising activity.
A variety of powerful techniques that have allowed visualization of organ structure and function with exact detail have been introduced in the last twenty-five years.
A variety of practice guidelines and financial incentives are available to health care professionals to facilitate adoption.
A variety of visual capacities show significant age-related alterations.
Avascular , degenerate tissue fibers , consistent with tissue fibrosis were observed in @percent@ of the specimens.
Aven is a regulator of the DNA-damage response and G2 / M cell cycle progression.
Average age across groups was @number@ ± @number@ @date@ @number@ ± @number@ years and @number@ ± @number@.3 / 61.5 ± @number@ years , respectively.
Average age at baseline was @number@.1±8.9 years.
Average age at face lift was @number@ years ( range , @number@ to @number@ years ) .
Average age for each group was @number@ and @number@ years , respectively.
Average age was @number@ years ( SD = @number@ ) , @percent@ were female , and @percent@ were African American.
Average age was @number@ years ( standard deviation = @number@ ) .
Average baseline Mini-Mental State Examination score was @number@ ± @number@
Average BVL / year was clearly age and compartment dependent.
Average call taker response time was calculated using the number-of-speaker-turns and time-in-seconds measures.
Average dietary intakes fulfilled the amounts of Recommended Dietary Intake for Spanish elderly population , except for folate.
Average education resulted in poorer performance and learning than higher education , mainly in older adults.
Average E / Ea ratio increased significantly with advancing age ( P < @number@ ) .
Average employment income deficiency was € @number@ before vs. € @number@ after diagnosis , but the increasing difference showed a linear shape throughout the period.
Average expenditure on nonsurgical treatments prior to rhytidectomy was $ 7000 cumulatively.
Average exposure time of the surgeons and the operating room staff per augmented level was @number@ seconds.
Average frequency of communication ( or meeting ) measures how often network members communicate ( or meet ) each other.
Average funding was $ 499 , 859 for multiple-PI awards vs. $ 397 , 932 for single-PI awards.
Average gait and gait variability measures were collected on a computerised walkway.
Average incidence of 3-10 / 1000 person-years is rising at around @percent@ per year.
Average induction magnitude was invariant with age for both test field heights.
Average initial IGA was @number@ ( SEM = @number@ ) and average final IGA was @number@ ( SEM = @number@ ) .
Average interval from the time of admission to surgery became @number@ days.
Average length of stay following surgery was @number@ ± @number@ days.
Average levels of LSA scores were higher in those with better functional performance and those who reported less mobility difficulties.
Average lifespan has increased over the last centuries , as a consequence of medical and environmental factors , but maximal life span remains unchanged.
Average MMSE-score was @number@ with dementia @number@ without @number@
Average monthly costs per class were $ 1 , 713 during the first year of implementation and $ 873 during the second year of implementation.
Average operative radiation time was @number@ seconds per level ( 33-160 ) .
Average operative time was 86minutes [ 61-110 ] and blood loss was estimated as minor in all the cases.
Average operative time was @number@ minutes ( 49-350 ) .
Average patient age was @number@ years ( range , 39-91 ) .
Average proximal and nadir CD4 counts were @number@ and @number@ respectively ; 15 / 38 ( @percent@ ) met criteria for HIV-associated neurocognitive disorder.
Average RBC life span is @number@ ± @number@ days.
Average scan time increased with age ( @number@ to > 60 s ) .
Average scores on the AAS students were @number@ ± @number@ points.
Averages of mean and maximal carotid IMT were @number@ ± @number@ mm and @number@ ± @number@ mm , respectively.
Averages of these dynamic diameters were calculated for each age group and by gender , and differences between them were tested.
Average SUR images were displayed in 2D and 3D space to illustrate the image patterns.
Average susceptibility values from each region were compared between the patients and controls.
Average telomere length in cell samples generally declines with donor age but shows substantial intraspecific variation.
Average telomere length was measured by quantitative PCR.
Average time between midlife examination and end of follow-up was @number@ years.
Average time since diagnosis was @time@ ( SD = 5.70 ) .
Average total distance and treadmill speed were @number@ km / week and @number@ km / h , respectively.
Average total hospital charges for the dexmedetomidine group were approximately $ 4000.00 less than the propofol group.
Average values of IMT of the right and left CCA patients of South Asian group were significantly lower than those of Slavic ethnicity.
Average weekly television viewing time was derived from two questions about weekday and weekend viewing.
A vertex analysis of thalamic shape was also performed.
A very low daily intake of energy ( < 20 kcal / kg body weight / day ) was observed in @percent@ of the participants.
A very low lifetime risk was found in individuals with an optimal profile of risk factors which modified the effect of aging.
A very simple model was used in this paper and many crucial mechanisms of biological aging were omitted.
A very small tripeptide amide ( L-PHP , Thyrotropin-Releasing Hormone , TRH ) , was first identified in the brain hypothalamus area.
A very strong correlation was found between the L1 slope and whole-spine sagittal balance ( P < @number@ r = @number@ ) .
AVLT performance decreased with age , and women outperformed men.
AVM-related death occurred in three patients ( @number@ by surgery and @number@ by observation ) .
Avoidance of cigarette smoking and frequent participation in sports activities may partially counteract this deleterious phenomenon of ageing.
Avoidance of overweight from adolescence onwards is likely important for cardiovascular disease prevention.
Avoidance of the use of tanning beds is an important component of education for teenagers.
Avoidant coping was negatively related to work ability.
Avoiding axillary surgery and undergoing sentinel lymph node dissection in elderly patients are both associated with better short-term QOL.
Avoiding costly complications and focusing on health promotion rather than disease management will be key.
Avoiding delay should be the major aim of the prehospital phase of acute stroke care.
A voiding diary is necessary to diagnose the syndrome of nocturnal polyuria , which is a common cause of nocturia.
Avoiding reporting erroneous results requires implementation of quality indicators.
A voxel based algorithm inspecting the local neighborhood is presented and used to segment the trabecular network into horizontal and vertical oriented bone.
A voxel-based mixed model analysis was used to compare groups with and without subsequent impairment.
A voxel-level hierarchical clustering approach was used to obtain the main clustering partitions corresponding to the cortical distribution maps of 18F-T807 and 11C-PiB.
AVR is forbidden by guidelines in severe AS patients with no symptoms.
AVR was independent of the arteriolar wall thickness , age and arterial hypertension.
AV synesthetes demonstrated increased parietal theta , alpha , and lower beta current density compared to nonsynesthetes.
Awareness and the use of hormone replacement therapy ( HRT ) are generally low and noted to vary significantly among populations from different Asian countries.
Awareness and treatment of the neurological and systemic complications of acute stroke are an integral part of management.
Awareness campaigns , such as the Heart Truth and the Red Dress symbol , appear to have improved recognition of CVD risk in women.
Awareness did fluctuate , and differences in interpretations of awareness were linked to the meaning assigned to particular kinds of responses.
Awareness may not be increased and the attentional demand may be shared between balance and mental task.
Awareness of and support for the vitamin D supplementation guidelines among health care providers is still limited.
Awareness of complications related to hypertension was given as the main reason for adherence to therapy.
Awareness of delirium in the patients with these factors is recommended.
Awareness of frailty , functional , social , and potential maltreatment issues enables early referrals to help the patient maintain her independence.
Awareness of health disparities is crucial for individuals with disabilities to minimize additional health-related challenges.
Awareness of risk factors that affect the course during admission can be useful in optimizing care and outcomes.
Awareness of such symptoms by the clinician could lead to better treatment.
Awareness of the diagnosis of hypertension was ascertained by self-reports.
Awareness of the importance of health literacy and numeracy should inform future educational efforts about fertility.
Awareness of these findings could expedite diagnosis.
Awareness of these patterns can help interventionists better target sedentary time and may aid in the identification of health risks associated with sedentary behavior.
Awareness of these signs is critical , as the eyelids and eyes may be affected even in the absence of patient recognition.
Awareness of the variety of ways that older men understand depression can help clinicians identify and engage them in depression treatment.
Awareness was associated with better performance on the TMT ( β = @number@ p < @number@ ) .
Awareness was positively associated with diabetes in Kingston , Manizales and Natal.
A water-soluble formulation of CoQ10 ( WS-CoQ10 ) was shown to stabilize mitochondria and prevent oxidative stress-induced neuronal death.
A WBC cutoff value greater than @number@ 10 ( @number@ ) / µl may predict the development of MetS in elderly women.
A weak association between severe cognitive impairment ( exposure ) and tooth loss ( outcome ) was identified after the adjustment for potential covariates.
A weaker correlation was observed with paternal age.
A weak relationship between age and Spatial Span Total Score was found.
A wealth of evidence indicates that lysine acetylation and deacetylation are critical for brain development and functionality.
A wealth of published evidence showed that telomere stability can be more affected than the bulk of the genome by several conventional antineoplasic drugs.
A wealth of published evidence showed that telomere stability can be more affected than the bulk of the genome by several conventional antineoplastic drugs.
A wealth of scientific evidence has implicated cell senescence as an important component in the etiology of these age-dependent pathologies.
A Web-based calculator is provided to assist neuropsychologists with interpretation of longitudinal change.
A web server named RevssPred can be accessed freely from : @url@ .
A website containing information with simple language , clear purpose and concise content was designed based on scientific evidence.
A week later , all subjects expressed a preference rate on reproductions of the same works presented in the gallery.
A weighted multivariable linear regression model determined the association between SHS exposure and cotinine levels among smokers.
A weighted sum score of lack of social connections ( LSC ) was estimated.
A well-defined example of how protein expression can change with age is that of the plasma proteome.
A well-designed and adequately powered RCT , which includes carer strain and quality of life as outcome measures is therefore urgently needed.
A well-designed , observational study could also answer fundamental questions of major importance to patients and their families regarding outcomes after delirium.
A well-established feature of physiological ageing is altered immune function , a phenomenon termed immunesenescence.
A well-established marker of the aging process is the length of the protective cap at the ends of chromosomes , called telomeres.
A well-known relation exists between peripheral artery disease and the number of diseased coronary vessels.
A well-matched nonsurgical comparison group of @number@ children with similar clinical characteristics was also assessed.
A well-structured program involving geriatricians , physiatricians and physiotherapists could be helpful for better short-term prognoses.
A well-studied DNA methylation-based phenomenon is genomic imprinting ( ie , genotype-independent parent-of-origin effects ) .
A well-tested questionnaire was used to collect information on reproductive variables.
A well-timed diagnosis and treatment is necessary in preventing further vertebral fracture and their consequences.
A widely accepted dogma is that about 15-20% of cardiac output is received by the brain in healthy adults under resting conditions.
A wide range of activities was included-political , mental , socio-cultural , social , physical , and organizational activities.
A wide range of choices and sources of information were discussed.
A wide range of demographic , employment , injury and clinical characteristics were investigated.
A wide range of microglia functions is recognized.
A wide range of socio-economic , demographic , and health variables were adjusted for.
A wide selection of antihypertensive drugs are currently available for managing hypertension , with distinct advantages and disadvantages in selected patient populations.
A widespread inverse relationship of fractional anisotropy ( FA ) values in SWM with age was observed.
A wide variation in thermal cycling parameters applied in experimental studies has been identified.
A wide variety of accelerometer systems , with differing sensor characteristics , are used to detect impact loading during physical activities.
A wide variety of bacteria or yeast species are isolated.
A wide variety of dermatoses may arise in exposed areas and are at the same time induced or exacerbated by irradiation from the sun.
A wide variety of flavours , celebrity endorsements and e-cigarettes specifically for women were presented.
A wide variety of herbal therapies are used , and some of these herbs have estrogenic activities in vitro.
A wide variety of interventions with dementia-related symptoms was found to be effective to varying degrees.
A wide variety of new results emerge from the combination of methodologies.
A within-person daily change in sleep duration was significantly associated with worse global cognitive performance.
A within-subjects , cross-sectional design embedded in a larger longitudinal study design.
A woman's reproductive lifespan can be shortened after chemotherapy or radiation because such treatments likely decrease the number of viable eggs after treatment.
A word recognition in noise experiment was used to test the hypothesis that cingulo-opercular engagement provides performance benefit for older adults.
A workforce that understands principles of geriatric medicine is critical to addressing the care needs of the growing elderly population.
A working group , the Subjective Cognitive Decline Initiative ( SCD-I ) , published SCD research criteria in the context of preclinical AD.
A xenograft tumor model of SAS-R was also resistant to @number@ Gy / day of X-rays for @number@ days.
Axial , coronal , and sagittal images , T1- and T2-weighted , were obtained.
Axial CT images with a gantry tilt angle of @number@ were analyzed.
Axial DW images were obtained and mean diffusivity ( MD ) maps were generated.
Axial length is not related to astigmatism , indicating that the measurement and correction of astigmatism are important even in emmetropia eyes.
Axial length of the eye , depth of anterior chamber , lens's thickness and vitreous's dimension increase over time.
Axial length of the eye , depth of anterior chamber , lens's thickness and vitreous's dimension was defined.
Axial length was measured using IOLMaster ( Carl Zeiss Meditec , Dublin , CA ) .
Axial length was not correlated with the amount of astigmatism ( r = 0.179 , P = 0.203 ) .
Axial T2-weighted MRI scans were acquired at the level of facet joint from each subject.
Axonal and dendritic morphology affect synaptic signaling , integration , and connectivity , and their diversity reflects the computational specialization of neural circuits.
Axonal degeneration is a central process in the pathogenesis of several neurodegenerative diseases.
Axonal transport deficits are a common feature of several neurodegenerative disorders and may represent a point of intersection of PS and tau function.
Axonal transport is critical for supplying newly synthesized proteins , organelles , mRNAs , and other cargoes from neuronal cell bodies into axons.
Axonal transport is essential for neuronal function , and many neurodevelopmental and neurodegenerative diseases result from mutations in the axonal transport machinery.
Axons depend critically on axonal transport both for supplying materials and for communicating with cell bodies.
A yellow filter should be considered as a potential means for visual improvement in normal aging.
A yoga practice diary was used to confirm regular performance of yoga.
A younger untrained group provided a nonexercising comparison.
A young healthy control group was included to assess effects of physiological aging.
A young patient with this syndrome was referred to our department because of a pigmented tumor which was suspected to be a malignant melanoma.
AZD8055 , a specific mTOR inhibitor , effectively prevented BMS-777607-induced polyploidy and senescence and restored survivin expression and its nuclear localization to normal levels.
A zero-inflated negative binomial ( ZINB ) regression model was fitted to the data.
A ZPD is an ongoing cognitive / affective activity in which learning and development occur as participants interact.
Aβ 1-40 and Aβ 1-42 display anti-bacterial , anti-yeast and anti-viral activities.
Aβ1-40 , in contrast , appears to partially localize in extracellular spaces in whole brain and is preferentially secreted by cultured neurons.
Aβ40 and Aβ42 are the two main components of amyloid plaques in AD brains , with Aβ42 being more prone to aggregation.
Aβ42 levels were significantly reduced in DDQ-treated mutant APPSwe / Ind cells.
Aβ42 was unrelated to cognitive change.
Aβ accumulation in turn leads to further decreases in the CBF closing the vicious cycle.
Aβ accumulation leads to the formation of Aβ aggregates , which may directly and indirectly lead to eventual neurodegeneration.
Aβ activates the complement cascade and its deposition is associated with activated macrophages.
Aβ affects both activation of insulin receptors and the levels of phospho-Akt , a critical signalling molecule in this pathway.
Aβ also disrupted synaptic vesicle recycling and protein folding machinery.
Aβ and hypoxia can evoke inflammation , oxidative stress and finally neuronal cell death.
Aβ and lipopolysaccharide ( LPS ) elicited similar M cytokine and exosomal mRNA ( ex-mRNA ) responses.
Aβ and tau biomarkers had high accuracy to discriminate cases and controls ( testing area under the curve : @number@ ) .
Aβ and tau imaging will enable to establish the role Aβ and tau play -and interplay- in aging and disease.
Aβ₂₅₋₃₅ concentration dependently decreased viability , proliferation , and mobilization of NSCs and GV1001 treatment restored the cells to wild-type levels.
Aβ deposition results in the production of reactive oxygen species ( ROS ) leading to the hyperphosphorylation of tau that are associated with neuronal damage.
Aβ deposition was associated with mixed PWV , systolic BP , and MAP.
Aβ drives the disease pathway through tau , with eTau further increasing Aβ levels , perpetuating a destructive cycle.
Aβ fails to suppress long-term potentiation in PLD2-deficient hippocampal slices , suggesting that PLD2 is required for the synaptotoxic action of this peptide.
Aβ₂₅₋₃₅ increased free radical levels in rat NSCs while combined treatment with GV1001 significantly reduced these levels.
Aβ-induced gene expression alterations were compared with those caused by a synthetic aggregating protein to identify Aβ-specific effects.
Aβ-induced synaptic abnormalities , including altered receptor trafficking and synapse loss , have been linked to cognitive deficits in AD.
Aβ is a cleavage product of Amyloid Precursor Protein ( APP ) .
Aβ is derived from β-amyloid precursor protein ( APP ) through sequential cleavages by β- and γ-secretases.
Aβ is generated from amyloid-β precursor protein ( APP ) through sequential cleavages first by β-secretase and then by γ-secretase.
Aβ is generated from the canonical amyloid-β precursor protein ( APP ) proteolysis pathway through β- and γ-secretases.
Aβ is generated through a serial cleavage of AβPP by β- and γ-secretase.
Aβ is present in the brain of symptom-free people where it likely performs important physiological roles.
Aβ oligomer levels did not strongly associate with age or gender , but had an inverse correlation with MMSE score.
Aβ-O treatment resulted in activation of caspase-3 and eIF2α , effects that were considerably attenuated following Aβ-O removal.
Aβ + participants exhibited increased gray matter in the lateral parietal lobe bilaterally relative to the Aβ- group , and no areas of significant atrophy.
Aβ peptides , which cause early synaptic dysfunctions , spine loss , and memory deficits , also disturb intracellular Ca ( 2 + ) homeostasis.
Aβ plaque load and astrocytosis were measured at @number@ and @number@ months of age by immunohistochemistry.
Aβ plaque load and astrocytosis were unaltered by fluparoxan treatment in TASTPM mice.
AβPP can also be processed by α-secretase , which cleaves AβPP within the Aβ sequence , thereby preventing the generation of Aβ.
Aβ production by cortical neurons of APPSwe / PS1dE9 mice was reduced by deletion of p75NTR gene in vitro.
Aβ toxicity was modeled by bilateral intracerebroventricular injections of the toxic fragment Aβ.
Aβ + was associated with older age , female sex , and showed trends for maternal family history of AD and APOE4.
B1 cells were also found to have increased in the thy mus.
BA and BMC values were expressed as a percentage of young-adult values to determine if and when values reached a plateau.
Baastrup disease was judged present if there was close contact between adjacent spinous processes and if the apposing ends were sclerotic.
Baastrup disease was most common at L4-L5.
Babrow's ( @number@ @number@ ) problematic integration theory provides a framework for this research.
BACE1 activation is caused due to oxidative stresses and dysfunction of ubiquitin-proteasome system ( UPS ) , which is linked to p53 inactivation.
BACE1 activity is regulated by membrane lipids and raft formation.
BACE1 cleaves over @number@ putative substrates , however the majority of these cleavages have not been characterized.
BACE1 is being evaluated as an anti-Aβ target for AD therapy.
BACE-1 levels also were a mean of 7-fold higher in ADEs than in NDEs from cultured rat type-specific neural cells.
BACE1-mediated contactin-2 cleavage tightly regulates the surface expression of contactin-2 in neuronal cells.
BACE1 ( β-secretase ) plays a central role in the β-amyloidogenesis of Alzheimer's disease ( AD ) .
BACE expression increases in response to aging and various stress stimuli.
BACE is considered as a rational drug target for AD therapy , and inhibitors are under development.
Back and leg pain severity decreased by @percent@ and @percent@ , respectively , during the follow-up period ( both P < @number@ ) .
Back function scores improved @percent@ compared to baseline.
Background.
Background.
BACKGROUND.
BACKGROUND : 18F-FDG-PET is defined as a biomarker of neuronal injury according to the revised National Institute on Aging Alzheimer's Association criteria.
BACKGROUND : Aberrant DNA methylation in gene promoters is associated with aging and cancer , but the circumstances determining methylation change are unknown.
BACKGROUND : Ablative fractional photothermolysis ( AFP ) has been reported to be effective in the treatment of photoaging.
BACKGROUND : Ablative fractional skin resurfacing has become popular and proven to be useful in treating scars , photoaging and wrinkles.
BACKGROUND : About half of colorectal patients are diagnosed less than @number@ years of age and they have a relatively high cure rate.
BACKGROUND : Accelerated telomere shortening may cause cancer via chromosomal instability , making it a potentially useful biomarker.
BACKGROUND : Accessing information that defines personally familiar context in real-world situations is essential for the social interactions and the independent functioning of an individual.
BACKGROUND : Accidental falls in the elderly are a major health problem , despite extensive research on risk factors and prevention.
BACKGROUND : According to the aging in Japan , surgery of lung cancer with cardiovascular disease is increasing.
BACKGROUND : Accumulating evidence implicates leukocyte telomere length ( LTL ) shortening as a potential risk predictor for cardiovascular disease.
BACKGROUND : Accumulation of DNA damage leading to adult stem cell exhaustion has been proposed to be a principal mechanism of aging.
BACKGROUND : Accurate assessment of cognitive functioning is an important step in understanding how to better evaluate both clinical and cognitive competence in practicing surgeons.
BACKGROUND : Accurate diagnosis of Plasmodium infection is crucial for prompt malaria treatment and surveillance.
BACKGROUND : Accurate estimation of prognosis in multimorbid hospital patients could improve quality of care.
BACKGROUND : Accurate measurement devices are required to objectively quantify physical activity.
BACKGROUND : Accurate measurement of the extent skin has aged is crucial for skin aging research.
BACKGROUND : A Centenarian is a person who attains and lives beyond the age of @number@
BACKGROUND : Acetylcholinesterase inhibitors ( AChEIs ) and the N-methyl D-aspartate-antagonist memantine are indicated for the symptomatic treatment of Alzheimer's disease ( AD ) .
BACKGROUND : Achilles tendinopathy is a degenerative process of the tendon associated with diminished vascularity , microtrauma , and aging.
BACKGROUND : A close relationship between aging , inflammation , and prostate cancer is widely accepted.
BACKGROUND : A computerized physician order entry ( CPOE ) system provides opportunity for real-time alerts to prescribers.
BACKGROUND : A considerable amount of research has been published about genetic hearing impairment.
BACKGROUND : A consistent and low-to-moderate association between markers of oral infection and loss of cognitive function has been demonstrated in the literature.
BACKGROUND : A constantly increasing number of gel fillers for aesthetic and reconstructive purposes have been introduced during the last @number@ years.
BACKGROUND : ' Active ageing ' has been promoted as a strategy for extending quality of life and healthy life expectancy.
BACKGROUND : Active ageing is a key to healthy ageing ; shopping behaviour is an economically relevant activity of the elderly.
Background activity ( BA ) and episodic and continuous abnormalities were assessed visually in EEG.
BACKGROUND : Acute decompensated heart failure ( ADHF ) was a frequent common outcome in SPRINT ( Systolic Blood Pressure Intervention Trial ) .
BACKGROUND : Acute respiratory failure is a rare life threatening complication following thyroid surgery and its incidence is reported as high as @percent@.
BACKGROUND : Acyl-ghrelin is thought to have both orexigenic effects and to stimulate GH release.
BACKGROUND : Adaptive postural control can be impaired in the presence of frailty syndrome , given that this condition causes homeostatic dysregulation in physiological systems.
BACKGROUND : A decline in prevalence of late-life disability in activities of daily living ( ADLs ) has been reported in Western countries.
BACKGROUND : Adequate and sufficient data on pain in nursing home residents is still lacking in Austria.
BACKGROUND : Adequately recording diastolic heart sounds and systolic time intervals over longer periods is difficult.
BACKGROUND : Adipocytokines are bioactive molecules that are deeply involved in the occurrence of atherosclerosis , obesity , and autoimmune inflammatory diseases.
BACKGROUND : Adipose-derived mesenchymalstromal cells ( ASC ) are currently tested in regenerative medicine to promote tissue reconstruction after injury.
BACKGROUND : Adipose tissue-derived stromal cells ( ADSCs ) are being recognized as a source of stem cells potentially useful for cardiovascular repair.
BACKGROUND : Adiposity indicators can be used as predictors of cardiovascular risk in the elderly.
BACKGROUND : A diverse set of neurodegenerative disorders are caused by abnormal extensions of polyglutamine ( poly-Q ) stretches in various , functionally unrelated proteins.
BACKGROUND : Adrenomedullin ( ADM ) is a circulating vasoactive peptide involved in vascular homeostasis and endothelial function.
BACKGROUND : Adult height has been hypothesized to be inversely associated with coronary heart disease ; however , studies have produced conflicting results.
BACKGROUND : Adulthood acute lymphoblastic leukemia ( ALL ) is a rare disease.
BACKGROUND : Adults aging with HIV are at greater risk for several comorbidities.
BACKGROUND : Adults aging with HIV infection are at risk for age-related comorbidities and syndromes , such as frailty.
BACKGROUND : Adult T-cell leukemia ( ATL ) is caused by human T-cell leukemia virus type @number@ ( HTLV-1 ) infection.
BACKGROUND : Advanced age is related to left ventricular ( LV ) remodeling.
BACKGROUND : Advanced age is the most important risk factor for atrial fibrillation ( AF ) ; however , the mechanism remains unknown.
BACKGROUND : Advanced glycation end products ( AGE ) accumulate in human tissue proteins during aging , particularly under hyperglycemia conditions.
BACKGROUND : Advanced glycation end-products ( AGE ) are pivotal in aging and diabetes.
BACKGROUND : Advanced glycation endproducts are biologically active compounds that accumulate in disordered metabolism and normal aging.
BACKGROUND : Advanced glycation end products are involved in the vascular complications of diabetes , in chronic kidney disease , and in the aging process.
BACKGROUND : Advanced heart failure is linked with structural and functional alterations in the brain.
BACKGROUND : Advancement in human immunodeficiency virus ( HIV ) therapies has increased life expectancy.
BACKGROUND : Advances in gerontology have yielded crucial insights into the molecular and biochemical aspects of the ageing process.
BACKGROUND : Adverse aortic remodeling , such as dilation , is associated with multiple cardiovascular disease ( CVD ) risk factors.
BACKGROUND : Adverse drug events in the ambulatory care setting are not uncommon and can cause significant morbidity.
BACKGROUND : Adverse drug reactions are a major cause of hospital admissions in older individuals , with the majority potentially preventable.
BACKGROUND : Adverse early life conditions such as perceived low quality of parental bonding increase vulnerability to stress and psychopathology in adulthood.
BACKGROUND : Adverse loading conditions and cardiac injury lead to remodelling of the heart into different patterns of left ventricular ( LV ) geometry.
BACKGROUND : Adverse reactions to injectable filler may be challenging to treat.
BACKGROUND : A dysregulated axis ( HPA ) is thought to play a role in the pathophysiology of cognitive impairment.
BACKGROUND : Aerobic and isometric exercises are known to decrease pain sensitivity.
BACKGROUND : Aerobic exercise training ( AET ) has been shown to provide health benefits in individuals with Parkinson's disease ( PD ) .
BACKGROUND : Aerobic training has some benefits for delaying the onset or progression of Alzheimer's disease ( AD ) .
BACKGROUND : AF-associated loci span broad genomic regions that may contain multiple susceptibility signals.
BACKGROUND : A frailty index ( FI ) based on the accumulation of deficits typically has a submaximal limit at about @number@
BACKGROUND : African Americans develop chronic kidney disease and pulmonary hypertension ( PH ) at disproportionately high rates.
BACKGROUND : African Americans have historically had high high-density lipoprotein cholesterol ( HDL-C ) compared with other races and ethnicities.
BACKGROUND : After a hip fracture , a catabolic state develops , with increased bone loss during the first year.
BACKGROUND : Age-adjusted cardiovascular disease ( CVD ) prevalence rates are significantly lower in Japan than in the United States.
BACKGROUND : Age appropriateness of anticoagulants for stroke prevention in atrial fibrillation is uncertain.
BACKGROUND : Age-associated brain physiologic decline and reduced mobility are key elements of increased age-associated vulnerability.
BACKGROUND : Age changes in expression of inflammatory , synaptic , and neurotrophic genes are not well characterized during human brain development and senescence.
BACKGROUND : Aged patients ( > 50 years old ) with residual schizophrenic symptoms differ from young patients.
BACKGROUND : Ageing drug users are a growing population who have problems accessing services and support.
BACKGROUND : Ageing has become a serious challenge in Hong Kong and globally.
BACKGROUND : Ageing is a multifaceted and inevitable process involving a decline in health and well-being that could be ameliorated by dietary modification.
BACKGROUND : Ageing is associated with geometrical changes in muscle fascicles that may lead to deteriorations in physical functions.
BACKGROUND : Ageing is characteristically accompanied by changes in vascular endothelial markers and growth factor as well as increased cellular death.
BACKGROUND : Ageing is defined as the time-dependent decline of functional capacity and stress resistance resulting in increased morbidity and mortality.
BACKGROUND : Ageing population implies an increasing demand for health care services and resources , unsustainable according to current previsions.
BACKGROUND : Age is associated with outcomes in non-ST-segment elevation myocardial infarction ; however , less is known about rehospitalization or death among elderly survivors.
BACKGROUND : Age is considered a primary risk factor for neurodegenerative diseases including Alzheimer's disease ( AD ) .
BACKGROUND : Age is considered a risk factor for manual handling-related injuries and older workers incur higher injury-related costs than younger co-workers.
Background : Age-related brain changes leading to altered socioemotional functioning may increase vulnerability to financial exploitation.
BACKGROUND : Age-related cataract is a major cause of morbidity.
BACKGROUND : Age-related cataracts , which probably form due to insolubilization of lens proteins , can lead to loss of vision.
BACKGROUND : Age-related changes in fat compartments have yet to be fully characterized.
BACKGROUND : Age-related changes in kidney structure and function have been well documented.
BACKGROUND : Age-related decline in kidney function can be an important risk factor for cognitive impairment in older adults.
Background : Age related decline in physical function is a significant concern affecting the quality of life of older individuals.
BACKGROUND : Age-related decrease in bone marrow erythropoietic capacity is often accompanied by the telomere length shortening in peripheral white blood cells.
BACKGROUND : Age-related differences in standing balance are not detected by testing the ability to maintain balance.
BACKGROUND : Age-related endothelial dysfunction and vascular stiffening are associated with increased cardiovascular ( CV ) risk.
BACKGROUND : Age-related hearing loss ( ARHL ) has been linked to the shift in the pro-oxidant / antioxidant ratio.
BACKGROUND : Age-related macular degeneration ( AMD ) is the leading cause of blindness in Western countries.
BACKGROUND : Age-related memory decline has been well-documented ; however , some individuals reach their 8th-10th decade while maintaining strong memory performance.
Background : Age-related mobility limitations are debilitating and common.
Background Age-related muscle atrophy is common in lower-limb muscles.
BACKGROUND : Age-related muscle loss ( that is , sarcopenia ) is a common health problem among older people.
BACKGROUND : Age-related olfactory loss ( presbyosmia ) is a prevalent sensory impairment with a large public health impact.
BACKGROUND : Age-related reduction in lower limb muscle strength has been shown to be related to disability , falls and loss of independence.
BACKGROUND : Age remains a robust risk factor for Alzheimer's disease as well as other dementias.
BACKGROUND : Aging adversely affects nitrogen accretion during health , but its effect during critical illness is unknown.
BACKGROUND : Aging and age-related health problems are major issues of concern for community health services.
BACKGROUND : Aging and atherosclerosis are related to renovascular hypertension in elderly individuals.
BACKGROUND : Aging and gender may affect left ventricular ( LV ) mechanics.
BACKGROUND : Aging and increasing comorbidity is changing the end-of-life experience of people living with HIV ( PLHIV ) in the developed world.
BACKGROUND : Aging and menopause are particular cardiovascular risk factors for women , due to estrogen deprivation at the time of menopause.
BACKGROUND : Aging and sedentary lifestyles lead to cardiac atrophy , ventricular stiffening , and impaired diastolic function.
BACKGROUND : Aging and sun exposure are the leading causes of skin cancer.
BACKGROUND : Aging and westernization of lifestyle has accelerated the prevalence and severity of atherosclerotic cardiovascular diseases in the Japanese population.
BACKGROUND : Aging causes physiological and functional changes that impair pulmonary function.
BACKGROUND : Aging compromises the ability of the central nervous system to maintain body balance and reduces the capacity for adaptive reactions.
BACKGROUND : Aging decreases bone marrow cellularity and alters the frequencies of stem cells.
BACKGROUND : Aging effects on speech understanding in noise have primarily been assessed through speech recognition tasks.
Background : Aging frailty , characterized by decreased physical and immunological functioning , is associated with stem cell depletion.
BACKGROUND : Aging has a recognized degenerative effect on the functionality of the hand in terms of strength and dexterity.
BACKGROUND : Aging has been associated with an increase in arterial stiffness.
BACKGROUND : Aging in an unfamiliar landscape can pose health challenges for the growing numbers of immigrants and their health care providers.
BACKGROUND : Aging in humans is characterized by a progressive loss of muscle mass and strength known as sarcopenia.
BACKGROUND : Aging in the malar fat pad is mainly caused by ptosis of the fibroadipose layer.
BACKGROUND : Aging involves reductions in exercise total limb blood flow and exercise capacity.
BACKGROUND : Aging is a biological process strongly determined by genetics.
BACKGROUND : Aging is accompanied by progression of depressive symptoms , which significantly impair the prognosis and quality of life of elderly men.
BACKGROUND : Aging is a complex and challenging phenomenon that requires interdisciplinary efforts to unravel its mystery.
BACKGROUND : Aging is a complex process relating multi-scale omics data.
BACKGROUND : Aging is a multifactorial process and depends on both intrinsic and extrinsic factors.
BACKGROUND : Aging is a multifactorial process characterized by organ loss of function and degeneration , but the mechanisms involved remain elusive.
BACKGROUND : Aging is an established risk factor for contrast-induced nephropathy ( CIN ) .
BACKGROUND : Aging is an inevitable part of life.
BACKGROUND : Aging is an inevitable process for all living organisms.
BACKGROUND : Aging is a risk factor for atherosclerosis.
BACKGROUND : Aging is associated with a decline in immune function.
BACKGROUND : Aging is associated with a loss of muscle mass ( sarcopenia ) and function.
BACKGROUND : Aging is associated with increased risk of reduced mobility.
BACKGROUND : Aging is associated with loss of balance and activity in daily life.
BACKGROUND : Aging is associated with muscle weakness and impairment in performing skilled motor tasks.
BACKGROUND : Aging is associated with progressive loss of muscle strength.
BACKGROUND : Aging is associated with thymus involution leading to a reduction in naive T cells and to an accumulation of effector-memory cells.
BACKGROUND : Aging is characterized by a state of chronic , low-grade inflammation that impairs vascular function.
BACKGROUND : Aging is often associated with modifications of gait.
BACKGROUND : Aging is often associated with various underlying comorbidities that warrant the use of multiple medications.
BACKGROUND : Aging is responsible for degenerative changes in all cartilage elements , thus impairing its properties and healing potential.
BACKGROUND : aging is under genetic control in C. elegans , but the mechanisms of life-span regulation are not completely known.
BACKGROUND : Aging is usually associated with increased levels of oxidants , and may result in damages caused by oxidative stress.
BACKGROUND : Aging leads to a panoply of changes of facial morphology.
BACKGROUND : Aging leads to low functional capacity and this can be reversed by safe and adequate exercise prescription.
BACKGROUND : Aging modifies immune response and respiratory physiology.
BACKGROUND : Aging negatively impacts on the function of resident human cardiac progenitor cells ( hCPCs ) .
BACKGROUND : Aging perceptions have been found to be major contributors to health in old age.
BACKGROUND : Aging plays a profound role in the ability of the kidney to function.
BACKGROUND : Aging populations are at increased risk of postoperative complications.
BACKGROUND : Aging produces inevitable changes in the function of most organs including the gastrointestinal tract.
BACKGROUND : Aging raises wide-ranging issues within social , economic , welfare , and health care systems.
BACKGROUND : Aging-related muscle loss is a public health problem.
BACKGROUND : Aging results in a decline in the function of the respiratory muscles.
BACKGROUND : Agitation is common across neuropsychiatric disorders and contributes to disability , institutionalization , and diminished quality of life for patients and their caregivers.
BACKGROUND : Agonist and antagonist muscle co-contractions during motor tasks are greater in the elderly than in young adults.
BACKGROUND : Agonistic angiotensin II type @number@ receptor autoantibodies ( AT1RaAbs ) have not been associated with functional measures or risk for adverse health outcomes.
BACKGROUND : A grafted donor liver should grow and survive under the different conditions presented by a liver transplantation recipient.
BACKGROUND : a growing number of older patients undergo cardiac surgery.
BACKGROUND : A growing number of positive airway pressure ( PAP ) device users will develop physical / sensory impairments such as arthritis.
BACKGROUND : A harmonious and youthful appearing neckline is arguably the most vital aspect of a successful facial rejuveation.
BACKGROUND : A high percentage of individuals treated in specialized acute care wards are frail and elderly.
BACKGROUND : A high prevalence of obesity has been increasingly recognized in survivors of pediatric ALL.
BACKGROUND / AIM : Exosomes have been demonstrated to be useful non-invasive biomarkers for several cancers including prostate cancer.
BACKGROUND & AIM : Guidelines promote dietitian consult ( DC ) for nutrition support.
BACKGROUND / AIM : Increasingly , health-care systems should promote seniors ' health and prevent disability.
BACKGROUND / AIM : Older people admitted to acute hospitals are at risk of functional decline.
BACKGROUND / AIM : Overweight and obesity may lead to a large number of health problems.
BACKGROUND / AIMS : Accurate staging of chronic kidney disease ( CKD ) is very important.
BACKGROUND & AIMS : Adequate protein intake and digestion are necessary to prevent muscle wasting in cystic fibrosis ( CF ) .
BACKGROUND AIMS : Adipose-derived stem cells ( ASC ) are known to be able to restore injured tissue via differentiation and paracrine effects.
BACKGROUND & AIMS : Age-related changes of body composition affect health status.
BACKGROUND & AIMS : Age-related physiological changes predispose even the healthy older adult to fluid and electrolyte abnormalities which can cause morbidity and mortality.
BACKGROUND / AIMS : Aging is associated with renal function decline and elderly patients are more vulnerable to acute kidney injury ( AKI ) .
BACKGROUND & AIMS : Associations of serum gamma-glutamyltransferase levels with a variety of incident diseases and mortality have been suggested.
BACKGROUND / AIMS : Chronic urticaria ( CU ) is defined as itchy wheals lasting @number@ weeks or more.
BACKGROUND & AIMS : Diabetes mellitus is prevalent in many countries around the world , but the potential causal factors are not clearly known.
BACKGROUND / AIMS : Difficulties with bathing are frequent among older people and are associated with an increasing need for societal support.
BACKGROUND / AIMS : Erythrocytes may enter eryptosis , a suicidal death characterized by cell shrinkage and phosphatidylserine exposure at the erythrocyte outer membrane.
BACKGROUND & AIMS : Falling is a major issue in geriatric health.
BACKGROUND AIMS : Flap necrosis is the most commonly encountered outcome influencing the effect of operations in clinical practice.
BACKGROUND & AIMS : Healthcare-associated infections [ HAI ] are common in elderly individuals and may be related to both nutritional deficiencies and immunosenescence.
BACKGROUND & AIMS : Insulin resistance of protein metabolism occurs in obesity and type @number@ diabetes ( T2D ) .
BACKGROUND & AIMS : Intestinal epithelial homeostasis is maintained by complex interactions among epithelial cells , commensal gut microorganisms , and immune cells.
BACKGROUND / AIM : Sirtuins ( SIRTs ) play crucial roles in various signaling pathways that modulate differentiation and proliferation.
BACKGROUND & AIMS : Lean body mass loss has been indicated as a reliable marker of frailty and poor physical performance among older individuals.
BACKGROUND & AIMS : Life expectancy is an important consideration when assessing appropriateness of preventive programs for older individuals.
BACKGROUND / AIMS : Mesenchymal stem cells ( MSCs ) play an important role in regulating angiogenesis and immune balance.
BACKGROUND AIMS : Mesenchymal stromal cells ( MSCs ) are used as experimental immunotherapy.
BACKGROUND & AIMS : Metabolic syndrome ( MetS ) is associated with incident disability in middle-aged subjects.
BACKGROUND & AIMS : Muscle wasting commonly occurs in COPD , negatively affecting outcome.
BACKGROUND / AIMS : Non-toxic fomitopsis is has been traditionally used in folk medicine in many countries for its anti-inflammatory and anti-vascular disease activities.
Background / Aims Nursing homes are complex healthcare systems serving an increasingly sick population.
BACKGROUND & AIMS : Nutritional failure in children with cystic fibrosis ( CF ) has a negative effect on their morbidity and survival.
BACKGROUND & AIMS : Risk for colorectal cancer ( CRC ) can be greatly reduced through screening.
BACKGROUND & AIMS : Screening colonoscopy is an effective method to reduce the incidence of and mortality from colorectal cancer ( CRC ) .
BACKGROUND & AIMS : Screening the population for colorectal cancer ( CRC ) by colonoscopy could reduce the disease burden.
BACKGROUND / AIMS : Stiff arteries cause high pulse pressure and flow to be transmitted to distal organs during systole , damaging the cerebral microvasculatures.
BACKGROUND / AIMS : The japanese population have the longest-life expectancy in the world.
BACKGROUND / AIMS : The mechanisms that regulate the size-related morphologies of various blood vessels from the aorta to capillary vessels are still poorly understood.
BACKGROUND / AIMS : There are few studies that evaluate the clinical outcomes of individuals with non-amnestic mild cognitive impairment ( MCI ) .
BACKGROUND & AIMS : The requirement of leucine and essential amino acids ( EAA ) to stimulate muscle protein synthesis increases with age.
BACKGROUND & AIMS : The results of studies assessing relationships between vitamin E intake and status and lung function are conflicting.
BACKGROUND / AIMS : The threshold number of endoscopic ultrasound ( EUS ) criteria for diagnosing chronic pancreatitis ( CP ) is variable.
BACKGROUND & AIMS : We aimed to characterize age-related changes in the gastric mucosa and investigate the contribution of Helicobacter pylori infection to these changes.
BACKGROUND / AIM : The adipocytokines leptin and adiponectin represent a critical link between metabolism , immunity and chronic inflammation.
Background / Aim The \ "asphalt identikit \ " theory suggests that driving cessation inevitably leads to feelings of incompetence and dependency.
BACKGROUND / AIM : The decrease of skin elasticity on the cheek is a major concern to woman.
BACKGROUND / AIM : The definition of muscle atrophy ( pre-sarcopenia ) and its diagnostic criteria have not been well reported.
BACKGROUND / AIM : The phenomenon of ageing is so commonplace that it is ordinarily taken-for-granted , with little call to question its meaning.
BACKGROUND : Air pollution has been related to mean changes in outcomes , including DNA methylation.
BACKGROUND : Air pollution is associated with adverse human health , but mechanisms through which pollution exerts effects remain to be clarified.
BACKGROUND : Air pollution is known to be a leading cause of respiratory symptoms.
BACKGROUND : Airway walls in asthma present an accumulation of activated cells that determine bronchial structural changes and disease progression and severity.
BACKGROUND : A key principle of acute surgical service provision is the establishment of a distinct patient flow process and an emergency theatre.
BACKGROUND : A lack of biomarkers that identify patients at risk for severe osteoarthritis ( OA ) complicates development of disease-modifying OA drugs.
BACKGROUND : A large proportion of European children , adults and older adults do not engage in sufficient physical activity ( PA ) .
BACKGROUND : Alcohol and cannabis are among the most widely used and abused drugs in industrialized societies.
BACKGROUND : Aldehyde dehydrogenases ( ALDHs ) play a major role in detoxification of aldehydes.
BACKGROUND : Aldosterone acts to restrain the extracellular potassium ( K + ) concentration.
BACKGROUND : Aldosterone plays a detrimental role on the cardiovascular system and PA patients display a higher risk of events compared with EH.
BACKGROUND : A limited body of evidence , mostly based on self-report , is available regarding physical activity levels among American-Indian adults.
BACKGROUND : All antipsychotic medications carry warnings of increased mortality for older adults , but little is known about comparative mortality risks between individual agents.
BACKGROUND : Allergic rhinitis ( AR ) and nonallergic rhinitis ( NAR ) may present with different clinical and laboratory characteristics.
BACKGROUND : Allometric exponents in population pharmacokinetic analysis are regularly used but the issue of fixing or estimating an allometric exponent remains controversial.
BACKGROUND : Alongside the global population ageing phenomenon , there has been a rise in the number of individuals who suffer from multiple chronic conditions.
BACKGROUND : A low concentration of serum folate is associated with an increased risk of cardiovascular disease.
BACKGROUND : Alterations in autonomic tone and / or sinus node dysfunction are common with aging.
BACKGROUND : Alterations in dental status or both physical and biological change associated with age can impact on oral disease and oral function.
BACKGROUND : Although alcohol risk is heritable , few genetic risk variants have been identified.
BACKGROUND : Although data remain contradictory , rapid response systems are implemented across US hospitals.
BACKGROUND : Although dialysis prolongs life for patients with end-stage kidney disease , @percent@ of deaths in this population are preceded by dialysis therapy withdrawal.
BACKGROUND : Although fall predictions using motor ability have been well reported in elderly people , there are few reports on physical cognitive ability.
BACKGROUND : Although fatty acids are known to be important in various skin functions , their roles on photoaging in human skin are poorly understood.
BACKGROUND : Although functional task-specific training is a viable approach for upper extremity neurorehabilitation , its appropriateness for older populations is unclear.
BACKGROUND : Although hearing loss may be caused by various factors , it is also a natural phenomenon associated with the aging process.
BACKGROUND : Although incidence rates are well documented for traumatic brain injury , lifetime prevalence in a demographically diverse sample is unknown.
BACKGROUND : Although increasingly more lead extraction was performed for superfluous leads , the extraction of such leads remains controversial.
BACKGROUND : Although millions of aesthetic procedures are performed annually , few patient-reported outcome ( PRO ) measures have been used in this setting.
BACKGROUND : Although Parkinson's disease ( PD ) is clinically characterized by motor symptoms , cognitive impairment is one of the most disabling non-motor symptoms.
BACKGROUND : Although physical activity has substantial health benefits and reduces mortality , few studies have examined its impact on survival beyond age @number@
BACKGROUND : Although physical inactivity is a major public health problem , the causative factors for physical inactivity per se are poorly understood.
BACKGROUND : Although sepsis is the leading cause of death from infection , there are few population-level epidemiological sepsis reports.
BACKGROUND : Although stroke is known to result in executive dysfunction , little is known about executive dysfunction as a risk factor for stroke.
BACKGROUND : Although the association between lead and cardiovascular disease is well established , potential mechanisms are still poorly understood.
BACKGROUND : Although the negative consequences on health of being obese are well known , most adults gain weight across the lifespan.
BACKGROUND : Although there is no agreement on a definition of elderly , commonly an age cutoff of ≥65 or @number@ years is used.
BACKGROUND : Although tracheal invasion from thyroid cancer is life-threatening , the epidemiology of its development remains unclear.
BACKGROUND : ALU element instability could contribute to gene function variance in aging , and may partly explain variation in human lifespan.
BACKGROUND : Alzheimer dementia ( AD ) is a major cause of debility and economic strain in aging societies around the world.
Background : Alzheimer disease results in progressive functional decline , leading to loss of independence.
BACKGROUND : Alzheimer's disease ( AD ) affects twice as many women as men.
BACKGROUND : Alzheimer's disease ( AD ) commonly accompanies cerebral amyloid angiopathy ( CAA ) .
BACKGROUND : Alzheimer's disease ( AD ) is a complex , irreversible neurodegenerative disorder.
BACKGROUND : Alzheimer's disease ( AD ) is a neurodegenerative disorder primarily characterized by the deposition of β-amyloid plaques in the brain.
BACKGROUND : Alzheimer's disease ( AD ) is a progressive neurodegenerative disorder.
BACKGROUND : Alzheimer's disease ( AD ) is a progressive neurodegenerative disorder in which infection with Chlamydia pneumoniae ( Cpn ) has been associated.
BACKGROUND : Alzheimer's disease ( AD ) is characterized by progressive memory loss and impaired cognitive function.
BACKGROUND : Alzheimer's disease ( AD ) is characterized pathologically by the presence of amyloid plaques and neurofibrillary tangles in the brain.
BACKGROUND : Alzheimer's disease ( AD ) is the leading form of dementia worldwide.
BACKGROUND : Alzheimer's disease ( AD ) is the most common type of dementia and is prevalent worldwide.
BACKGROUND : Alzheimer's disease ( AD ) is the most common type of presenile and senile dementia.
BACKGROUND : Alzheimer's disease and other forms of dementia are becoming increasingly common with the aging of most populations.
BACKGROUND : Alzheimer's disease is a neurodegenerative syndrome characterized by multiple dimensions including cognitive decline , decreased daily functioning and psychiatric symptoms.
BACKGROUND : Alzheimer's disease is characterized by amyloid-beta ( Aβ ) plaques and neurofibrillary tangles.
BACKGROUND : Ambient particulate matter ( PM ) has been associated with mortality and morbidity for cardiovascular disease.
BACKGROUND : Ambulatory blood pressure monitoring ( ABPM ) is recommended to assess hypertensive status in patients with chronic kidney disease ( CKD ) .
BACKGROUND : Among indigenous Mam-Mayan women , breastfeeding practices may be intertwined with cultural influences during the early postpartum period.
BACKGROUND : Among nondiabetic individuals , higher fasting blood glucose ( FBG ) independently predicts diabetes risk , cardiovascular disease , and dementia.
Background : Among older adults , both olfaction and motor function predict future cognitive decline and dementia , suggesting potential shared causal pathways.
BACKGROUND : Among older adults , life satisfaction ( LS ) correlates with health , mortality , and successful ageing.
BACKGROUND : Among older people in developed countries , social isolation leading to solitary death has become a public health issue of vital importance.
BACKGROUND : Among older persons , disability is often precipitated by intervening illnesses and injuries leading to hospitalization.
BACKGROUND : Among senior drivers , benzodiazepines ( BZDs ) have a documented effect on the risk of road traffic crashes ( RTCs ) .
BACKGROUND : A monophasic , highly crosslinked hyaluronic acid dermal filler offers further treatment options for deep lines.
BACKGROUND : A myriad of technologies are available for the treatment of aging skin.
BACKGROUND : An ageing workforce combined with increasing health problems in ageing workers implies the importance of evidence-based interventions to enhance sustainable employability.
BACKGROUND : An aging population and the increasing prevalence of chronic diseases have led to the increased use of medicines.
BACKGROUND : An aging population means that chronic illnesses , such as diabetes , are becoming more prevalent and demands for care are rising.
BACKGROUND : Analyses of moderate drinking have focused overwhelmingly on average consumption , which masks diverse underlying drinking patterns.
BACKGROUND : A national surveillance program of colon cancer treatment was introduced in @number@
BACKGROUND AND AIM : Acidosis is able to induce negative changes of different organs that increase progressively with aging.
BACKGROUND AND AIM : Chronic diseases , like dementia , can lead to care dependency and nursing care problems.
BACKGROUND AND AIM : Cinacalcet effectively reduces calcium in patients with persistent hyperparathyroidism ( HPT ) after kidney transplantation.
BACKGROUND AND AIM : Dilated perivascular spaces ( dPVS ) have previously been associated with aging and hypertension-related cerebral microangiopathy.
BACKGROUND AND AIM : Elderly patients are frequently affected by gallstone-related disease.
BACKGROUND AND AIM : Health status is an independent predictor of mortality , morbidity and functioning in older people.
BACKGROUND AND AIM : How cortisol , a stress biological marker , differs according to depressive symptoms has mostly been examined in high-income countries.
BACKGROUND AND AIM : Liver regeneration likely decreases with age by an , as yet , incompletely understood mechanism , restricting the extent of hepatectomy.
BACKGROUND AND AIMS : A close relationship exists between dual-task ( DT ) -related gait changes and the risk of falling in the elderly.
BACKGROUND AND AIMS : Adipokine levels may have a role in the diagnostic and prognostic evaluation of malnutrition.
BACKGROUND AND AIMS : Ageing trends in populations are common amongst most European countries.
BACKGROUND AND AIMS : Aging is a complex and multifactorial process that is stimulated by a number of factors including genes and life-style.
BACKGROUND AND AIMS : Although pain in the elderly is a common and important problem , it is frequently underestimated and undertreated.
BACKGROUND AND AIMS : An epidemiological analysis of cases of spontaneous community acquired septic arthritis in an elderly population at a university teaching hospital.
BACKGROUND AND AIMS : Aortic atherosclerosis is an aggregate marker of vascular risk factor exposure and has been associated with intracranial atherosclerosis and stroke.
BACKGROUND AND AIMS : Atrial fibrillation ( AF ) is the most frequent arrhythmia in elderly patients.
BACKGROUND AND AIMS : Atrial fibrillation ( AF ) typically prevails on male sex in all decades of life.
BACKGROUND AND AIMS : Blood pressure control is closely related to target organ damage in elderly patients with hypertension.
BACKGROUND AND AIMS : Caregiving can be extremely stressful , especially when patients ' ability to communicate is impaired.
BACKGROUND AND AIMS : Cognitive decline and heart failure frequently coexist in the elderly.
BACKGROUND AND AIMS : Comparative data on locomotive and non-locomotive physical activity ( PA ) by age and gender are lacking for Japanese adults.
BACKGROUND AND AIMS : Diabetic ketoacidosis ( DKA ) is still a severe complication associated with significant morbidity and mortality.
BACKGROUND AND AIMS : Dizziness , impaired balance and fear of falling are common complaints in the elderly.
BACKGROUND AND AIMS : DNA methylation of repetitive elements may explain the relations between dietary intake , hyperhomocysteinemia , and cardiovascular disease risk.
BACKGROUND AND AIMS : Endurance training may reduce orthostatic tolerance.
BACKGROUND AND AIM : Several measurements were taken for frailty classification in geriatric population.
BACKGROUND AND AIMS : Falls among older people are associated with injury , functional decline , fear of falling , and depression.
BACKGROUND AND AIMS : Falls causing injuries among older people and the consequences of those injuries are of increasing concern to public health practitioners.
BACKGROUND AND AIMS : Familiarity is assumed to exert a beneficial effect on memory in older adults.
BACKGROUND AND AIMS : Few studies have evaluated long-term durability of glycemic control in older patients.
BACKGROUND AND AIMS : Frailty is a common situation that often influences clinical outcomes , disability or institutionalization.
BACKGROUND AND AIMS : Glycemic control in geriatric patients with type @number@ diabetes ( T2DM ) remains clinically challenging.
BACKGROUND AND AIMS : Hip fracture in older people is an event associated with a high incidence of morbidity and mortality.
BACKGROUND AND AIMS : Home-based exercise is a viable alternative for older adults with difficulties in exercise opportunities outside the home.
BACKGROUND AND AIMS : Hospital admissions from Nursing Homes ( NHs ) are associated with high mortality.
BACKGROUND AND AIMS : Hospital readmission after discharge is an important clinical and health policy issue.
BACKGROUND AND AIMS : In advanced age , the influence of vertebral fractures on quality of life extends well beyond the usual sequelae of osteoporosis.
BACKGROUND AND AIMS : Increased fear of falling is associated with greater muscular coactivation during standing postural control.
BACKGROUND AND AIMS : In various populations , vitamin D deficiency is associated with chronic diseases and mortality.
BACKGROUND AND AIMS : Knowledge about Health-Related Quality of Life ( HRQoL ) in advanced age is sparse.
BACKGROUND AND AIMS : Many older adults with dementia are hospitalized for diagnoses other than dementia.
BACKGROUND AND AIMS : Many studies have reported a greater frequency of falls among older women than men in conditions which stress balance.
BACKGROUND AND AIMS : Mental training has the potential to enhance motor performance and behavior in older adults.
BACKGROUND AND AIMS : Metabolic syndrome and osteoporosis are recognized as major public health problems in many countries.
BACKGROUND AND AIMS : Metabolic syndrome has been reported to have adverse effects on cognition although the results are conflicting.
BACKGROUND AND AIMS : Mildly elevated homocysteine ( Hcy ) and oxidative stress are novel and potentially modifiable risk factors for post-menopausal osteoporosis.
BACKGROUND AND AIMS : More than genetic and physical influences , different environmental stimuli affect brain reserve , and bilingualism is one example.
BACKGROUND AND AIMS : Nursing home residents constitute a frail , multi-diseased and heterogeneous group.
BACKGROUND AND AIMS : Olfactory testing is useful in the differential diagnosis of age-related pathologies.
BACKGROUND AND AIMS : Osteoarthritis ( OA ) of the knee or hip is associated with limitations in activities of daily life.
BACKGROUND AND AIMS : Outcome prediction is important in clinical practice.
BACKGROUND AND AIMS : Physical function and quality of life represent two major components of multidimensional evaluation in older people.
BACKGROUND AND AIMS : Physiological aging can lead to an increase in blood pressure ( BP ) over time even in regularly exercising elders.
BACKGROUND AND AIMS : Pictograms , designed to be a universal communication system , are often created from several concrete and easily recognizable drawings.
BACKGROUND AND AIMS : Poor self-rated health is associated with adverse outcomes but its relationship with frailty is not completely understood.
BACKGROUND AND AIMS : Postal questionnaires are widely used in health research to provide measurable outcomes in areas such as quality of life.
BACKGROUND AND AIMS : Postmenopausal status is correlated with increased metabolic syndrome ( MetS ) and cardiovascular risks.
BACKGROUND AND AIMS : Previous studies have confirmed that chronic kidney disease ( CKD ) influences the cognitive function of adults.
BACKGROUND AND AIMS : Quality monitoring has great relevance in stroke care.
BACKGROUND AND AIMS : Reducing health care costs through preventive geriatric care has become a high priority in Japan.
BACKGROUND AND AIMS : Sarcopenia has been indicated as a reliable marker of frailty and poor prognosis among the oldest individuals.
BACKGROUND AND AIMS : Sarcopenia staging systems have been proposed , but little is known on their application in hip-fracture patients.
BACKGROUND AND AIMS : Several studies have reported that regular consumption of breakfast is associated with health benefits.
BACKGROUND AND AIMS : Sporadic colorectal cancer ( CRC ) development is a sequential process showing age-dependency , uncontrolled epithelial proliferation and decreased apoptosis.
BACKGROUND AND AIMS : Studies that have attempted to address the influence of exercise programs on muscle strength have usually analyzed single exercise training types.
BACKGROUND AND AIMS : Surveillance is an integral part of the colorectal cancer ( CRC ) screening process.
BACKGROUND AND AIMS : The effectiveness of community-based fall assessment programs in older people is unclear.
BACKGROUND AND AIMS : The free radical theory of aging has been receiving a lot of attention in the past years.
BACKGROUND AND AIMS : The Houston Intra-Arterial Therapy score predicts poor functional outcome following endovascular treatment for acute ischemic stroke based on clinical variables.
BACKGROUND AND AIMS : The hypothesis of increased cardiovascular risk contributing to chronic dizziness has been discussed controversially so far.
BACKGROUND AND AIMS : The information about clinical presentation and outcome of elderly hepatocellular carcinoma ( HCC ) patients is limited.
BACKGROUND AND AIMS : There is no conclusive evidence that hospital fall prevention programs can reduce the number of falls.
BACKGROUND AND AIMS : The relative contribution of different domains on walking speed is largely unknown.
BACKGROUND AND AIMS : The telomere length of peripheral blood leukocytes has been reported to be inversely correlated with many kinds of pathophysiological conditions.
BACKGROUND AND AIMS : The term frailty is used to describe older persons at high risk for adverse health outcomes.
BACKGROUND AND AIMS : This paper aims to estimate if the education level modifies the association of income with disability prevalence in the elderly.
BACKGROUND AND AIMS : This study examined whether remembering location information relies on efficient inhibitory functions.
BACKGROUND AND AIMS : Unsupported standing is one of the most important functional tasks involving balance control.
BACKGROUND AND AIMS : Vision is an important prerequisite for balance control and mobility.
BACKGROUND AND AIMS : We aimed to identify clusters of metabolic syndrome ( MetS ) components , risky for extremely high intima-media thickness.
BACKGROUND AND AIMS : We investigated body composition in knee osteoarthritis ( OA ) patients and evaluated its relationship with clinical parameters and radiographic severity.
BACKGROUND AND AIM : Syncope and related falls are one of the main causes and the predominant cause of hospitalization in elderly patients with dementia.
BACKGROUND AND AIM : The use of transdermal therapeutic systems has spread worldwide since they allow effective local drug delivery.
BACKGROUND AND OBJECTIVE : Adoption studies have been used to disentangle the influence of genes from shared familial environment on various traits and disease risks.
BACKGROUND AND OBJECTIVE : A variety of laser or light-based devices have been developed for skin rejuvenation.
BACKGROUND AND OBJECTIVE : Food insecurity negatively impacts HIV disease outcomes in international settings.
BACKGROUND AND OBJECTIVE : Fractional Er : YAG 2940-nm laser resurfacing is a relatively new approach to the treatment of photodamaged skin.
BACKGROUND AND OBJECTIVE : Fractional photothermolysis with a CO2 laser shows promise in the treatment of photodamaged skin.
BACKGROUND AND OBJECTIVE : Hospitalization for exacerbation of COPD is associated with a high risk of mortality.
BACKGROUND AND OBJECTIVE : Human motor skills or impairments have been traditionally assessed by neurologists by means of paper-and-pencil tests or special hardware.
BACKGROUND AND OBJECTIVE : Lack of baseline values is a limitation in the quantification of physical performance testing of the low back muscles.
BACKGROUND AND OBJECTIVE : Laser non-ablative fractional treatment ( NAFT ) is an important part of armamentarium of modern dermatology.
BACKGROUND AND OBJECTIVE : Muscular dysfunction and cognitive impairment are both disabling states , affecting especially the elderly.
BACKGROUND AND OBJECTIVE : Oxycodone is a widely used opioid analgesic , the global use of which has increased several-fold during the last decade.
BACKGROUND AND OBJECTIVE : Poor back endurance is a predictor of low back pain.
BACKGROUND AND OBJECTIVE : Psychological well-being as one of the most important indicators of successful aging has received substantial attention in the gerontological literature.
BACKGROUND AND OBJECTIVE : Q-Switched Nd : YAG lasers produce photoacoustic effects in addition to photothermal effects which may allow for greater tissue collagen production.
BACKGROUND AND OBJECTIVE : Renal disease is a common complication in HIV-infected patients.
BACKGROUND AND OBJECTIVE : Rivastigmine and donepezil are two cholinesterase inhibitors ( ChEIs ) indicated for the treatment of mild-to-moderate Alzheimer's disease.
BACKGROUND AND OBJECTIVES : Aging and malnutrition are known to influence immune functions.
BACKGROUND AND OBJECTIVES : Ankle-brachial index ( ABI ) is currently recommended for the screening of peripheral arterial disease.
BACKGROUND AND OBJECTIVES : Blood products have a vital role in saving many patients ' lives.
BACKGROUND AND OBJECTIVES : CKD is associated with mortality.
BACKGROUND AND OBJECTIVES : Cross-sectional studies have found that low serum bicarbonate is associated with slower gait speed.
BACKGROUND AND OBJECTIVES : Decreased hippocampal volume in older adults is associated with neurodegenerative and psychiatric diseases.
BACKGROUND AND OBJECTIVES : Elevations in N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T are associated with poor cardiovascular outcomes.
BACKGROUND AND OBJECTIVES : Higher levels of inflammatory markers have been associated with renal outcomes in diabetic populations.
BACKGROUND AND OBJECTIVES : Increasing rates of obesity among Chinese adolescents has become a major public health concern in recent years.
BACKGROUND AND OBJECTIVES : Infection and cardiovascular disease are leading causes of hospitalization and death in patients on dialysis.
BACKGROUND AND OBJECTIVE : Single-item screening questions may be a practical first step in screening for cognitive problems in older people.
BACKGROUND AND OBJECTIVE : Skeletal muscle has been suggested as an important factor in the pathophysiology of metabolic syndrome.
BACKGROUND AND OBJECTIVES : Kidney disease is associated with physiologic changes that may predispose to frailty.
BACKGROUND AND OBJECTIVES : Lifetime risk estimates of CKD can be used effectively in public education campaigns.
BACKGROUND AND OBJECTIVES : Multipotent mesenchymal stem cells ( MSCs ) represent a promising cell-based therapy for a number of degenerative conditions.
BACKGROUND AND OBJECTIVES : Non-ablative fractional lasers cause little down-time , however , some patients want more noticeable results with fewer treatments.
BACKGROUND AND OBJECTIVES : Older women rarely receive post-mastectomy breast reconstruction ( PMBR ) .
BACKGROUND AND OBJECTIVES : One in seven HIV-infected individuals is incarcerated each year.
BACKGROUND AND OBJECTIVES : Population aging has emerged as a major demographic trend worldwide.
BACKGROUND AND OBJECTIVES : Reduced lean mass and physical function is a characteristic of frailty.
BACKGROUND AND OBJECTIVES : Short telomere length has been described to be associated with biological aging including atherosclerosis phenotypes.
BACKGROUND AND OBJECTIVES : Smoking is known to increase biological age.
BACKGROUND AND OBJECTIVES : Soluble Klotho is an anti-aging phosphaturic protein associated with vascular-renal protection.
BACKGROUND AND OBJECTIVES : Studies have demonstrated that some cutaneous biophysical properties vary with age , gender and body sites.
BACKGROUND AND OBJECTIVES : Systolic BP and large elastic artery stiffness both increase with age and are reduced by dietary sodium restriction.
BACKGROUND AND OBJECTIVES : The ablative fractional CO₂ laser has been successfully used in treating photoaged skin in the Caucasian population.
BACKGROUND AND OBJECTIVES : The neuropsychological exam plays a central role in the assessment of elderly patients with cognitive complaints.
BACKGROUND AND OBJECTIVES : The relationships of dietary choline and folate intake with hepatic function have yet to be established in the Taiwanese population.
BACKGROUND AND OBJECTIVES : Various dietary strategies have been investigated to slow kidney function decline.
BACKGROUND AND OBJECTIVE : The correction of soft tissue contour defects and dermal atrophy is a growing area driven by medical and aesthetic need.
BACKGROUND AND OBJECTIVE : The cortisol awakening response ( CAR ) is a useful endocrine marker for the axis activity.
BACKGROUND AND OBJECTIVE : The mortality rate for patients requiring mechanical ventilation is about @percent@ and this rate increases to about @percent@ for the elderly.
BACKGROUND AND OBJECTIVE : To determine the association between frailty and mortality , dysfunctionality , falls and hospitalizations in the Mexican Health and Aging Study.
BACKGROUND AND OBJECTIVE : With the aging of the population , the incidence of lung cancer in elderly rises.
Background and outlining of the project are discussed.
BACKGROUND AND PURPOSE : Accumulating vascular pathology in cerebral arteries leads to impaired cerebral vasomotor reactivity.
BACKGROUND AND PURPOSE : Age might differentially affect outcomes in patients treated for unruptured cerebral aneurysms with surgical clipping versus endovascular coil therapy.
BACKGROUND AND PURPOSE : Akinetic crisis ( AC ) is the most severe and possibly lethal complication of parkinsonism.
BACKGROUND AND PURPOSE : Autoimmune encephalopathies ( AEs ) are a heterogeneous group of neurological disorders that affect cognition.
BACKGROUND AND PURPOSE : Automatic assessment of brain volumes is needed in research and clinical practice.
BACKGROUND AND PURPOSE : Cancer patients are at increased risk of cardiovascular and cerebrovascular events.
BACKGROUND AND PURPOSE : Carotid atherosclerosis is a risk factor for cerebrovascular disease in older adults.
BACKGROUND AND PURPOSE : Cerebral autoregulation may be impaired in the early days after subarachnoid hemorrhage ( SAH ) .
BACKGROUND AND PURPOSE : Cerebral microbleeds ( MBs ) are frequently detected in patients with stroke , especially those who experience intracerebral hemorrhage.
BACKGROUND AND PURPOSE : Degenerative changes are commonly found in spine imaging but often occur in pain-free individuals as well as those with back pain.
BACKGROUND AND PURPOSE : Detection rates of paroxysmal atrial fibrillation ( AF ) after acute ischemic stroke increase with duration of ECG monitoring.
BACKGROUND AND PURPOSE : Development of the CVJ is a complex process rarely analyzed by CT.
BACKGROUND AND PURPOSE : dVRS have been previously associated with aging and cerebrovascular diseases.
BACKGROUND AND PURPOSE : Essential tremor ( ET ) is amongst the most commonly encountered neurological disorders.
BACKGROUND AND PURPOSE : Exposure to vascular risk factors has a gradual deleterious effect on brain MRI and cognitive measures.
BACKGROUND AND PURPOSE : Extensive skin wrinkling during facial expressions is one of the considerable problems in aesthetic dermatology.
BACKGROUND AND PURPOSE : Fatiguing exercise can adversely alter postural stability and therefore may contribute to falling.
BACKGROUND AND PURPOSE : Genome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke ( IS ) .
BACKGROUND AND PURPOSE : Haptoglobin ( Hp ) is an acute phase plasma protein protecting tissues from oxidative damage.
BACKGROUND AND PURPOSE : In the brains of newborns , changes in signal intensity in most structures can be explained by the development of myelination.
BACKGROUND AND PURPOSE : Intracerebral hemorrhage ( ICH ) volume , particularly if ≥30 mL , is a major determinant of poor outcome.
BACKGROUND AND PURPOSE : Iron chelation therapy is emerging as a novel neuroprotective strategy.
BACKGROUND AND PURPOSE : It is important for patients recovering from coronary artery bypass ( CAB ) surgery to initiate and maintain recommended exercise guidelines.
BACKGROUND AND PURPOSE : It is not known if there is a relationship between gender and tissue outcome in human ischemic stroke.
BACKGROUND AND PURPOSE : Little is known about factors that predispose older adults to poor recovery after a stroke.
BACKGROUND AND PURPOSE : Motoric cognitive risk ( MCR ) syndrome is a pre-dementia syndrome.
BACKGROUND AND PURPOSE : Moyamoya disease ( MMD ) is characterized by unique angiographic features of collateralization.
BACKGROUND AND PURPOSE : Obesity and physical inactivity are independently associated with physical and functional limitations in older adults.
BACKGROUND AND PURPOSE : Physical activity has many benefits for older adults , but adherence is often low.
BACKGROUND AND PURPOSE : Proteinuria and estimated glomerular filtration rate ( eGFR ) are indicators of renal function.
BACKGROUND AND PURPOSE : Some prior studies have linked ambient temperature with risk of cerebrovascular events.
BACKGROUND AND PURPOSE : Some studies have reported associations between intracranial atherosclerosis and Alzheimer disease pathology.
BACKGROUND AND PURPOSE : Stroke is a medical emergency that can cause permanent neurological damage , complications , and disability.
BACKGROUND AND PURPOSE : TA is a branch of image processing that seeks to reduce image information by extracting texture descriptors from the image.
BACKGROUND AND PURPOSE : Thalamocortical connections play a crucial role in complex cognitive functioning , and several neuropsychiatric disorders may involve aberrant thalamocortical circuitry.
BACKGROUND AND PURPOSE : The arterial spin-labeling method for CBF assessment is widely available , but its accuracy is not fully established.
BACKGROUND AND PURPOSE : The association between stroke and subsequent dementia or Alzheimer disease is well established.
BACKGROUND AND PURPOSE : The extensive application of advanced MR imaging techniques has undoubtedly improved our knowledge of the pathophysiology of amyotrophic lateral sclerosis.
BACKGROUND AND PURPOSE : The measurement of cortical shrinkage is a candidate marker of disease progression in Alzheimer's.
BACKGROUND AND PURPOSE : The natural history of white matter hyperintensity ( WMH ) progression resulting from normal aging versus comorbid vascular insults remains unclear.
BACKGROUND AND PURPOSE : The presence of MATERIALS AND METHODS : This prospective study included @number@ community-dwelling elderly controls.
BACKGROUND AND PURPOSE : The purpose of our study was aimed to analyze the sex- and age-related differences of brain metabolism in healthy individuals.
BACKGROUND AND PURPOSE : There are few studies of spinal microvascular pathologies in older adults.
BACKGROUND AND PURPOSE : There is great interest in how endovascular clot retrieval hubs provide services to a population.
BACKGROUND AND PURPOSE : There is mounting evidence that essential tremor ( ET ) is a neurodegenerative disease.
BACKGROUND AND PURPOSE : To date , few studies have investigated how walking patterns on inclines change in healthy older adults.
BACKGROUND AND PURPOSE : Treatment of stroke consumes a significant portion of all healthcare expenditure.
BACKGROUND AND PURPOSE : Visit-to-visit variability in blood pressure ( vBP ) is associated with ischemic stroke.
BACKGROUND AND PURPOSE : Visualization of pathogenic protein aggregates is crucial to elucidate pathomechanisms and to make an accurate diagnosis in many neurodegenerative conditions.
BACKGROUND AND PURPOSE : We tested the hypothesis that posterior brain arteries differ pathologically from anterior brain arteries and that this difference varies with age.
BACKGROUND AND PURPOSE : White matter hyperintensities ( WMH ) of presumed vascular origin increase the risk of stroke and dementia.
BACKGROUND AND PURPOSE : White matter hyperintensities ( WMHs ) and brain atrophy frequently coexist in older people.
BACKGROUND AND RESEARCH OBJECTIVE : Today's complex healthcare system relies heavily on sophisticated self-care regimens.
BACKGROUND : Andropause is a middle-age condition in which men experience changes in their physical , spiritual and emotional health.
BACKGROUND : Anemia and frailty are both common in older people and are associated with adverse health outcomes.
BACKGROUND : Anemia is still one of India's major public health problems , especially among adolescent girls.
BACKGROUND : Anesthesiology has been identified as a stressful specialty.
BACKGROUND : Animal and cell studies suggest that magnesium may prevent calcification within atherosclerotic plaques underlying cardiovascular disease.
BACKGROUND : Animal and human studies have demonstrated increased collagen deposition in senescent hearts.
BACKGROUND : An impaired ability to allocate attention to gait during dual-task situations is a powerful predictor of falls.
BACKGROUND : An impaired HBsAg-secretion can increase HBV oncogenic-properties.
BACKGROUND : An impending crisis is looming over the oral healthcare of our aging population.
BACKGROUND : An increase in daily doses of protein and fiber for the elderly is relevant in preventing sarcopenia and preserving intestinal balance.
BACKGROUND : An increase of pertussis cases , especially in young infants and adolescents , has been noted in various countries.
BACKGROUND : An increasing number of medications that are frequently prescribed to elderly patients have been identified as having weak but definite anticholinergic properties.
BACKGROUND : Anorectal malformations ( ARM ) are rare forms of congenital uro-rectal anomalies with largely unknown causes.
BACKGROUND : Anterior cruciate ligament reconstruction ( ACLR ) has traditionally been reserved for young patients with functional instability.
BACKGROUND : Anthropometric parameters are closely associated with the pathophysiology of frailty and with clinic and functional parameters assessed for its diagnosis.
BACKGROUND : Anti-aging effects of high concentrations of salicylic acid ( SA ) peels are commonly known.
BACKGROUND : Antibody responses to seasonal influenza vaccines are defective during older age and human immunodeficiency virus ( HIV ) infection.
BACKGROUND : Anticoagulation management is difficult in chronic kidney disease , with frequent supratherapeutic international normalized ratios ( INRs ≥ @number@ ) increasing hemorrhagic risk.
BACKGROUND : Anti-glomerular basement membrane ( GBM ) disease is being recognized increasingly in older patients.
BACKGROUND : Anti-Müllerian hormone ( AMH ) is a promising marker of ovarian reserve.
BACKGROUND : Anti-oxidant capacity is crucial defence against environmental or endogenous oxidative stress.
BACKGROUND : antioxidants might protect against oxidative stress , which has been suggested as a cause of aging.
BACKGROUND : Antiplatelet therapy following a transient ischemic attack ( TIA ) constitutes an important secondary prevention measure.
BACKGROUND : Antipsychotics are commonly used in the elderly despite a lack of safety data from randomized trials , particularly for the typical antipsychotics.
BACKGROUND : Antipsychotics , especially atypical agents , are widely used in the elderly population to treat behavioural and psychiatric symptoms.
BACKGROUND : Antiretroviral safety and efficacy and may differ in older versus younger HIV-infected patients.
BACKGROUND : Antiretroviral therapy has increased longevity for people living with HIV ( PLWH ) .
BACKGROUND : Antiretroviral therapy has reduced the incidence of adverse events and early mortality in HIV-infected persons.
BACKGROUND : A @number@ , 927-nm wavelength was recently added to the @number@ , 550-nm erbium-doped fiber laser.
BACKGROUND : A number of studies have associated depression with a high mortality risk.
BACKGROUND : Aortic valve calcification ( AVC ) is a common progressive condition that involves several inflammatory and atherosclerotic mediators.
BACKGROUND : Aortic wall strains are indicators of biomechanical changes of the aorta due to aging or progressing pathologies such as aortic aneurysm.
BACKGROUND : A positive life orientation ( PLO ) is important for staying healthy physically , mentally and functionally.
BACKGROUND : Appearance-based education shows promise in promoting sunscreen use although resource-intensive methods used in prior studies preclude wide dissemination.
BACKGROUND : Approximately one-third of community-dwelling older adults fall each year , and approximately @percent@ have falls requiring medical services.
BACKGROUND : Approximately @percent@ of patients exploring treatments for wrinkle reduction , have reservations about toxins.
BACKGROUND : A pragmatic , stepped wedge trial design can be an appealing design to evaluate complex interventions in real-life settings.
BACKGROUND : A prospective study directed to musculoskeletal health in the manufacturing workforce.
BACKGROUND : aPWV is an independent predictor of cardiovascular risk and increases exponentially with age.
BACKGROUND : A range of new therapeutic agents are now available for the management of Alzheimer's disease.
BACKGROUND : A reduction in key antioxidants such as glutathione has been noted in brain tissue undergoing oxidative stress in aging and neurodegeneration.
BACKGROUND : A relationship between bulimia nervosa and reward-related behavior is supported by several lines of evidence.
BACKGROUND : Army vision standards have varied little from Aviation's nominal birth.
BACKGROUND : Around @percent@ of the population will experience herpes zoster ( HZ ) , @percent@ of whom develop postherpetic neuralgia ( PHN ) .
BACKGROUND : Arsenic exposure is associated with decreased kidney function.
BACKGROUND : Arsenic induces neural tube defects in many animal models.
BACKGROUND : Arsenic induces neural tube defects in several animal models , but its potential to cause neural tube defects in humans is unknown.
BACKGROUND : Arterial calcification is a common event in cardiovascular pathogenesis.
BACKGROUND : Arterial calcification is an important pathological change of diabetic vascular complication.
BACKGROUND : Arterial stiffening is one of the hallmarks of vascular aging , and is an important risk factor for cardiovascular morbidity and mortality.
BACKGROUND : Arterial stiffness and wall shear stress are powerful determinants of cardiovascular health , and arterial stiffness is associated with increased cardiovascular mortality.
BACKGROUND : Arterial stiffness is an important marker of vascular aging that is increased in sedentary , obese older adults.
BACKGROUND : Artificial sources of restricted light wavelength , particularly tanning beds , are progressively gaining importance in photoaging.
BACKGROUND : As adults age with human immunodeficiency virus ( HIV ) , the role for rehabilitation continues to emerge.
BACKGROUND : As antiretroviral therapy efficacy improves , HIV is gradually being recognized more as a chronic disease within the aging HIV-infected population.
BACKGROUND : As a result of the ageing population , there is an urgent need for innovation in community health-care in order to achieve sustainability.
BACKGROUND : As for all individuals , the Internet is important in the everyday life of older adults.
BACKGROUND : As greater numbers of us are living longer , it is increasingly important to understand how we can age healthily.
BACKGROUND : Asian Americans represent a mix of cultures and immigration experiences , which may put them differentially at risk for mental health problems.
BACKGROUND : Asian populations habitually consume a large amount of cruciferous vegetables and other plant-based foods.
BACKGROUND : Asians are prone to develop epidermal pigmentary lesions as a result of photoaging.
BACKGROUND : A single administration of laninamivir octanoate , a long-acting neuraminidase inhibitor , against influenza infection has been proven effective in nonclinical studies.
BACKGROUND : As kidney and brain functions decline with aging , chronic kidney disease ( CKD ) and dementia are becoming increasing health burdens worldwide.
BACKGROUND : As life expectancy continues to rise , more elderly are reaching advanced ages ( ≥80 years ) .
BACKGROUND : As microbial agents have been associated with late adverse effects related to fillers antibiotic treatment has been envisaged.
BACKGROUND : As one ages , physical , cognitive , and clinical problems accumulate and the pattern of loss follows a distinct progression.
BACKGROUND : As our society ages , improving medical care for an older population will be crucial.
BACKGROUND : As people live longer , their risk of disability increases.
BACKGROUND : Aspiration pneumonia is an urgent health concern with high mortality and long hospitalization in industrialized and aging countries.
BACKGROUND : Assays to evaluate platelet function are often interchangeably used to assess \ "resistance \ " to aspirin.
BACKGROUND : Assessing the clinical effectiveness of measuring grip strength as a prognostic tool in recovering ambulation in bed-confined frail elderly patients.
BACKGROUND : Assisted living ( AL ) is a growing and operationally diverse option in our nation's long-term care system.
BACKGROUND : Associations between inherited mitochondrial disease and cardiac conduction have been previously described.
BACKGROUND : Associations between long-term exposure to ambient particulate matter ( PM ) and cardiovascular ( CVD ) mortality have been widely recognized.
BACKGROUND : Associations between orthostatic blood pressure and cognitive status ( CS ) have been described with conflicting results.
BACKGROUND : As stem cells of the early embryo mature and differentiate into all tissues , the mitochondrial complement undergoes dramatic functional improvement.
BACKGROUND : As the aging population continues to increase , the surgical needs of the elderly will increase.
BACKGROUND : As the general population is aging , surgery in elderly patients has become a major public health issue.
BACKGROUND : As the global population grows , the percentage of those over @number@ will escalate disproportionately.
BACKGROUND : As the population ages , the burden on the healthcare system might increase and require changed public health priorities.
BACKGROUND : Asthma seems to present in the elderly as a specific phenotype that remains to be further described.
BACKGROUND : A substantial proportion of the general population has low lung function , and lung function is known to decrease as we age.
BACKGROUND : A surgical technique was developed to soften the nasolabial folds by liposuction and severing of the cutaneous insertions of the mimetic muscles.
BACKGROUND : As we age , the dynamic balance between gains and losses has been acknowledged by current portrayals of health.
BACKGROUND : Asymmetric dimethylarginine ( ADMA ) , an endogenous inhibitor of nitric oxide synthase , increase with advancing age and menopausal status.
BACKGROUND : Asymptomatic atrial fibrillation ( AF ) is increasingly common in the aging population and implicated in many ischemic strokes.
BACKGROUND : Ataxia Telangiectasia ( A-T ) is a rare monogenetic neurodegenerative disease with pulmonary , nutritional , and dysphagic complications.
BACKGROUND : Atherosclerosis is a common cardiovascular disease that causes myocardial infarction , heart failure , and stroke.
BACKGROUND : A thorough characterization of the morphological structure and physical properties is essential for an understanding of human hair.
BACKGROUND : A thorough understanding of gender differences in physical activity is critical to effective promotion of active living in older adults.
BACKGROUND : At present @number@ million people live with Alzheimer's disease around the world.
BACKGROUND : At present , the exact mechanism of postoperative delirium has not been elucidated.
BACKGROUND : At present , the influence of age on hemodynamic function is largely unknown.
BACKGROUND : Atrial arrhythmias are the most common complication encountered in the growing and aging population with congenital heart disease.
BACKGROUND : Atrial fibrillation ( AF ) is a common cardiac disease in aging populations with high comorbidity and mortality.
BACKGROUND : Atrial fibrillation ( AF ) is a highly prevalent disorder leading to heart failure , stroke , and death.
BACKGROUND : Atrial fibrillation ( AF ) is associated with higher risk of dementia and Alzheimer's disease.
BACKGROUND : Atrial fibrillation ( AF ) is common among frail older adults.
BACKGROUND : Atrial fibrillation is the most common sustained arrhythmia in the elderly.
BACKGROUND : Attitudes are known to exert a powerful influence on a range of behaviors.
BACKGROUND : Attitudes to the aging process are affected by the individual's sociocultural background.
BACKGROUND : Augmented arginase-II ( Arg-II ) is implicated in endothelial senescence and inflammation through a mutual positive regulatory circuit with S6K1.
BACKGROUND : Autogenous osteochondral grafting has been widely performed as a treatment for focal osteochondral defects.
BACKGROUND : Autonomic nervous activity plays a critical role in the genesis of paroxysmal atrial fibrillation ( AF , PAF ) .
BACKGROUND : Autophagy is a conserved molecular pathway involved in the degradation and recycling of cellular components.
BACKGROUND : Available evidence suggests that young adults and seniors use different strategies to adjust for increasing body sway during quiet standing.
BACKGROUND : Awareness represents a major modulator for the uptake of preventive measures and healthy life-style choices.
BACKGROUND : axis reactivity ( HPA AR ) is the key indicator of the psychophysiological response to stress.
BACKGROUND : Ayurveda represents the traditional medicine system of India.
BACKGROUND : Background levels of metals of toxicological or industrial importance have been reported for several populations in the world.
BACKGROUND : Background noise has been found to negatively affect working memory.
Background : Back problems and urinary incontinence ( UI ) have been found to co-occur more frequently than would be predicted by chance.
BACKGROUND : Balance deteriorates with age and fall related injuries are often linked to long-term disability and loss of independence in older adults.
BACKGROUND : Balance is commonly affected by multiple factors , especially among the elderly population.
BACKGROUND : Bariatric surgery is associated with cognitive benefits , but the nature of such gains may be variable across demographically and clinically diverse persons.
BACKGROUND : Bariatric surgery is associated with improved cognition , and it is possible that such improvements are found at extended follow-ups.
BACKGROUND : Baseline research on the toughness of Egyptian goose meat is required.
BACKGROUND : Basic lexical skills are hypothesised to be relatively preserved in mild dementia , but clinical studies have reported inconsistent results.
BACKGROUND : Basic social supports and services not routinely covered by insurers may be needed by terminally ill patients and their families.
BACKGROUND : B cells undergo maturation and class-switching in response to antigen exposure and T-cell help.
BACKGROUND : BDNF is known to induce neuroplasticity and low circulating levels have been related to neuronal loss in older persons.
BACKGROUND : Because creatinine is an unreliable variable describing kidney function , the search for a new and sensitive marker of kidney function is underway.
BACKGROUND : Because of a lack of efficacy of influenza vaccination in elderly population , there are still numerous outbreaks in geriatric health care settings.
BACKGROUND : Because of an increasing aging population worldwide , a greater number of elderly patients are being considered for hepatic resection.
BACKGROUND : Because of changing world demographics , the elderly population is steadily increasing.
BACKGROUND : Because of demographic changes of an aging society , palliative care is becoming increasingly important.
BACKGROUND : Because of population aging , prevention of CV disease in the elderly is relevant.
BACKGROUND : Because of the aging working population and the increasing age of retirement the number of workers with chronic illnesses and disabilities is growing.
BACKGROUND : Behavioral and psychological symptoms are widely accepted as accelerator factors in progression to dementia.
BACKGROUND : Behavioral and psychological symptoms of dementia ( BPSD ) are prevalent in people with neurodegenerative diseases.
BACKGROUND : Behavioral studies consistently reported an increased preference for positive experiences in older adults.
BACKGROUND : Behavior , while complex and dynamic , is among the most diverse , derived , and rapidly evolving traits in animals.
BACKGROUND : being able to identify individuals at high risk of dementia is important for diagnostics and intervention.
BACKGROUND : being unmarried is associated with worse health and increased mortality risk.
BACKGROUND : Benign prostate syndrome ( BPS ) is a common phenomenon in the aging male.
BACKGROUND : Benign prostatic hyperplasia ( BPH ) and lower urinary tract symptoms ( LUTS ) are conditions extremely prevalent in the aging male.
BACKGROUND : Benign prostatic hyperplasia is a common progressive disease in aging men , which leads to a significant impact on daily lives of patients.
BACKGROUND : Benign prostatic hyperplasia is a frequent disease among elderly , and is responsible for considerable disability.
BACKGROUND : Benzodiazepines are commonly prescribed in residential aged care facilities ( RACFs ) for their sedative and anxiolytic effects.
BACKGROUND : Besides tumor characteristics , colorectal cancer ( CRC ) outcomes are also determined by host factors , in particular the systemic inflammatory response.
BACKGROUND : Between- and within-person variation in DNA methylation levels are important parameters to be considered in epigenome-wide association studies.
BACKGROUND : Bilingualism may protect against cognitive aging and delay the onset of dementia.
BACKGROUND : Biofeedback is a scarce , resource-intensive clinical therapy.
BACKGROUND : Biological sex differences and sociocultural gender diversity influence endocrine stress reactivity.
BACKGROUND : Biological underpinnings of falls in older adults are not well established.
BACKGROUND : Biomechanical studies have shown that the horizontal center of mass momentum at seat-off during sit-to-walk is reduced among elderly adults.
BACKGROUND : Biophysical skin measurement techniques are widely used to quantify the skin barrier function.
BACKGROUND : Bisphosphonate-related osteonecrosis of the jaw ( BRONJ ) is a clinical condition characterized by the presence of exposed bone in the maxillofacial region.
BACKGROUND : Bitter taste is the primary culprit for rejection of pediatric liquid medications.
BACKGROUND : Black carbon ( BC ) is a pro-oxidant , traffic-related pollutant linked with lung function decline.
BACKGROUND : Blacks have higher stroke incidence and experience greater poststroke disability than whites.
BACKGROUND : Blood pressure ( BP ) increases with age and obesity.
BACKGROUND : Blood sugar metabolism abnormalities have been identified in HIV-infected individuals and associated with HIV-associated neurocognitive disorders ( HAND ) .
BACKGROUND : Blood transfusion is frequently required in children undergoing cardiac surgery and is associated with altered postoperative outcome.
BACKGROUND : Blood trauma caused by continuous-flow left ventricular assist devices ( CF-LVADs ) has been associated with device thrombosis and anemia.
BACKGROUND : Body composition changes with ageing can influence the adiponectin concentration.
BACKGROUND : Body composition has been shown to be correlated with physical performance , but data in older persons with diverse chronic diseases are lacking.
BACKGROUND : Bone marrow lesions ( BMLs ) are considered as predictors of pain , disability , and structural progression of knee osteoarthritis.
BACKGROUND : Bone metastases are a frequent complication of advanced oncologic disease.
BACKGROUND : Bone mineral density is known to decrease rapidly after the menopause.
BACKGROUND : Bone mineral density is presently the only reliable diagnostic test for osteoporosis.
BACKGROUND : Borderline personality disorder ( BPD ) is a chronic condition with a strong impact on patients ' affective , cognitive and social functioning.
BACKGROUND : Borderline Personality Disorder ( BPD ) is well-known to be a clinically severe and impairing diagnosis.
BACKGROUND : Both airflow limitation and obstructive sleep apnea-hypopnea syndrome ( OSAHS ) -related symptoms are most prevalent in the elderly population.
BACKGROUND : Both cognitive and physical exercise have been discussed as promising interventions for healthy cognitive aging.
BACKGROUND : Both increased age and type @number@ diabetes mellitus are risk factors for developing bone fractures.
BACKGROUND : Both motor and non-motor symptoms could contribute to significant deterioration of psychological well-being in patients with Parkinson's disease ( PD ) .
BACKGROUND : Both peripheral nerve blocks with sedation or general anesthesia can be used for total knee replacement surgery.
BACKGROUND : Both physical frailty and cognitive impairment predict death , but the joint effect of these two factors is uncertain.
BACKGROUND : Botulinum toxin A products have been used in aesthetics for more than @number@ years.
BACKGROUND : Botulinum toxin ( BT ) is a safe and effective treatment for cosmetic indications.
BACKGROUND : Botulinum toxin is a well-established treatment for dynamic glabellar lines.
BACKGROUND : Botulinum toxins are used for facial rejuvenation.
BACKGROUND : Botulinum toxins have been widely used in cosmetic dermatology.
BACKGROUND : Botulinum toxin Type A ( BoNT A ) for the treatment of facial wrinkles is delivered through local injection.
BACKGROUND : Botulinum toxin type A ( BoNTA ) is commonly injected to treat facial wrinkles.
BACKGROUND : Botulinum toxin type A has been widely used to correct unwanted hyperfunctional facial lines.
BACKGROUND : Brachial-ankle pulse wave velocity ( baPWV ) is inversely associated with cognitive function.
BACKGROUND : Brain atrophy in Alzheimer's disease ( AD ) includes not only AD-specific brain atrophy but also the atrophy induced by normal aging.
BACKGROUND : Brain glioma is a relatively rare and fatal malignancy in adulthood with few known risk factors.
BACKGROUND : Brain metastasis ( BM ) is a poor prognostic factor for non-small-cell lung cancer ( NSCLC ) .
BACKGROUND : Breast anthropometric morphology affects various factors with diverse physiognomy , making accurate measurements very difficult.
BACKGROUND : Breast cancer is the most common malignancy amongst elderly women and the main cause of mortality.
BACKGROUND : Breast cancer is the most frequently diagnosed cancer in women in the United States.
BACKGROUND : Breast fibroglandular ( dense ) tissue is a risk factor for breast cancer.
BACKGROUND : Brown adipose tissue ( BAT ) is abundant in small mammals and in newborns and helps them to survive cold temperatures.
BACKGROUND : Brugada syndrome ( BrS ) primarily associates with the loss of sodium channel function.
BACKGROUND : Bullous pemphigoid ( BP ) is the most frequently encountered autoimmune blistering disorder , affecting mainly elderly population.
BACKGROUND : B-vitamin deficiencies have been associated with depression ; however , there is very little prospective evidence from population-based studies of older adults.
BACKGROUND : By contrast with other southern European people , north Portuguese population registers an especially high prevalence of hypertension and stroke incidence.
BACKGROUND : Ca.
BACKGROUND : Cancer and Alzheimer's disease ( AD ) are common diseases of aging and share many risk factors.
BACKGROUND : Cancer incidence and social isolation increase along with advanced age , and social isolation potentiates the relative risk of death by cancer.
BACKGROUND : Cancer is a disease that affects mostly older adults.
BACKGROUND : Cancer is a disease that mostly affects older adults.
BACKGROUND : Cancer is a major health problem due to the aging population with increasing deaths.
BACKGROUND : Cancer mortality is increasing with the aging of the population in Japan.
BACKGROUND : Cancer prevalence trends are rarely reported in the published literature , and until now , have not been reported for Canada.
BACKGROUND : Cancers are emerging public health problems in developing countries like Nigeria.
BACKGROUND : Cancer survival is a key measure of the effectiveness of health-care systems.
BACKGROUND : Carboxytherapy ( CA ) refers to the cutaneous and subcutaneous administration of CO ( @number@ ) for therapeutic purposes.
BACKGROUND : Cardiac rehabilitation ( CR ) seeks to simultaneously improve several outcome parameters related to patient risk factors , exercise capacity and subjective health.
BACKGROUND : Cardiometabolic risk factors and related cardiovascular diseases represent major threats to healthy aging.
BACKGROUND : Cardiorespiratory fitness is associated with increased frontal and parietal activation during executive function tasks.
BACKGROUND : Cardiovascular and pulmonary symptoms influence health and well-being among older adults.
BACKGROUND : Cardiovascular disease and dementia are growing medical and social problems in aging societies.
BACKGROUND : Cardiovascular disease and its risk factors have consistently been associated with poor cognitive function and incident dementia.
BACKGROUND : Cardiovascular disease ( CVD ) and osteoporosis are @number@ major public health problems that share common pathophysiological mechanisms.
BACKGROUND : Cardiovascular disease ( CVD ) and related risk factors are associated with Alzheimer's disease ( AD ) .
BACKGROUND : Cardiovascular disease ( CVD ) is the principal contributor to the burden of disease and mortality worldwide.
BACKGROUND : Cardiovascular disease is the leading cause of death among patients with end-stage renal disease ( ESRD ) .
BACKGROUND : Cardiovascular fitness is associated with cognition in advanced age.
BACKGROUND : Cardiovascular remodeling leading to heart failure is common in the elderly.
BACKGROUND : Caregivers of persons with dementia are stressed.
BACKGROUND : Caregivers play a major role in the care of patients with dementia and are themselves at higher risk of disease.
BACKGROUND : care home residents are aged , many have multiple co-morbidities and low levels of functioning.
BACKGROUND : Carotid artery geometry has been suggested as a risk factor for atherosclerotic carotid artery disease ( ACD ) .
BACKGROUND : Carpal tunnel syndrome ( CTS ) , with unclear etiology , is the most common entrapment neuropathy.
BACKGROUND : Cataract is the leading cause of world blindness.
BACKGROUND : CD28 ( - ) T lymphocytes progressively increase during aging , autoimmunity , and HIV-1 infection.
BACKGROUND : Cell therapy for intrinsic urinary sphincter deficiency ( ISD ) in women has been moderately effective , and improvements are needed.
BACKGROUND : Cellular and animal studies suggest that hypercholesterolemia contributes to Alzheimer disease ( AD ) .
BACKGROUND : Cellular senescence irreversibly arrests growth of human diploid cells.
BACKGROUND : Cellular senescence is a specialized form of growth arrest that is generally irreversible.
BACKGROUND : Cellular senescence plays important roles in the aging process of complex organisms , in tumor suppression and in response to stress.
BACKGROUND : Cellulite is a widespread problem involving females ' buttocks and thighs based on the female specific anatomy.
BACKGROUND : Central nervous system ( CNS ) infiltration by CD8 T cells is associated with neuroinflammation in many neurodegenerative diseases , including HIV-associated dementia.
BACKGROUND : cerebral autoregulation ( CA ) is the ability to control cerebral blood flow during fluctuations in arterial blood pressure ( ABP ) .
BACKGROUND : Cerebral small vessel disease ( SVD ) has been suggested to be more common in Asians compared with Caucasians.
BACKGROUND : Cerebral small vessel disease ( SVD ) is very common in elderly and related to cognition , although this relation is weak.
BACKGROUND : Cerebral white matter lesions ( WML ) have been found in normal aging , vascular disease and several neuropsychiatric conditions.
BACKGROUND : Cerebrovascular reactivity to carbon dioxide ( CO ( @number@ ) R ) is affected by age , gender and anesthetic agents.
BACKGROUND : Cervical intervertebral disc herniation can lead to myelopathy.
BACKGROUND : Changes arising from the aging process , particularly changes in body composition , contribute to the functional decline of the elderly.
BACKGROUND : Changes in corpus callosum area and thickness have been reported in bipolar disorder.
BACKGROUND : Changes in DNA methylation are among the mechanisms contributing to the ageing process.
BACKGROUND : Changes in knee kinematics have been identified in the early stages of osteoarthritis ( OA ) .
BACKGROUND : Changes in the structure and functioning of the body occur with age.
Background characteristics and physical and mental health conditions were compared , with results showing differences cross the five subcategories of older Asian Americans.
BACKGROUND : Characterization of long-term health trajectory in older individuals is important for proactive health management.
BACKGROUND : Characterization of the variations in the metabolomic profiles of elderly people is a necessary step to understand changes associated with aging.
BACKGROUND : Charleston Harbor has elevated concentrations of PFAS in dolphins , but local human exposure data are limited.
BACKGROUND : Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men.
BACKGROUND : Chemotherapy-induced alopecia ( CIA ) is a frequent complication in patients with cancer.
BACKGROUND : Chemotherapy-induced peripheral neuropathy ( CIPN ) is the most common neurological and clinically relevant side effect of many commonly used chemotherapeutic agents.
Background : Chicago's Chinatown is home to a sizeable community of first-generation Chinese American immigrants.
BACKGROUND : Childhood adversity is associated with increased risk for mood , anxiety , impulse control , and substance disorders.
BACKGROUND : Childhood trauma is associated with increased vulnerability to mental and somatic disorders later in life.
BACKGROUND : children with Specific Language Impairment ( SLI ) have difficulties with speech processing.
BACKGROUND : China and India are the world's two most populous countries.
BACKGROUND : China has a large and aging population.
BACKGROUND : China's one-child-per-couple policy , introduced in @number@ led to profound demographic changes for nearly a quarter of the world's population.
BACKGROUND : Chiroptera , the bats , are the only order of mammals capable of true self-powered flight.
BACKGROUND : Chlorogenic acid is a potent phenolic antioxidant.
BACKGROUND : Choto-san is a traditional medicine used for hypertension and headaches in Japan and China.
BACKGROUND : Chronic diseases contribute a large share of disease burden in low- and middle-income countries ( LMICs ) .
BACKGROUND : Chronic exposure to the sun causes the skin to prematurely age.
BACKGROUND : Chronic heart failure ( CHF ) is an increasingly common condition with increasing prevalence in the aging population.
BACKGROUND : Chronic heart failure ( HF ) is a common , complex clinical syndrome characterized by dyspnea , fatigue and exercise intolerance.
BACKGROUND : Chronic heart failure , is increasing due to the aging population and improvements in heart disease detection and management.
BACKGROUND : Chronic inflammation and immune activation occur in both HIV infection and normal aging and are associated with inflammatory disease.
BACKGROUND : Chronic inflammation and oxidative stress might be considered the key mechanisms of aging.
BACKGROUND : Chronic inflammation is involved in the pathogenesis of chronic age-associated , degenerative diseases.
BACKGROUND : Chronic inflammation plays a key role in cancer etiology.
BACKGROUND : Chronic kidney disease ( CKD ) complicates hypertension and diabetes.
BACKGROUND : Chronic kidney disease ( CKD ) is associated with insulin resistance ( IR ) .
BACKGROUND : Chronic kidney disease is associated with malnutrition and inflammation.
BACKGROUND : Chronic kidney disease patients share clinical and pathological features with the general aging population.
BACKGROUND : chronic knee pain is still considered a fairly benign disease by many , an ' unavoidable ' consequence of ageing.
BACKGROUND : Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases.
BACKGROUND : Chronic lymphocytic leukemia ( CLL ) and chronic myeloid leukemia ( CML ) are highly treatable conditions occurring primarily in older patients.
BACKGROUND : Chronic migraine is a complex clinical condition often undertreated.
BACKGROUND : Chronic obstructive pulmonary disease ( COPD ) is a leading cause of morbidity and mortality worldwide.
BACKGROUND : Chronic obstructive pulmonary disease ( COPD ) is associated with high levels of hospitalization and health care expenditures among the aged.
BACKGROUND : Chronic obstructive pulmonary disease ( COPD ) mainly affects middle-age and elderly adults.
BACKGROUND : Chronic Obstructive Pulmonary Disease ( COPD ) may be associated with accelerated aging.
BACKGROUND : Chronic pain affects nursing home residents ' daily life.
BACKGROUND : Chronic pain is common in multimorbid patients.
BACKGROUND : Chronic pain is prevalent among older adults but is underrecognized and undertreated.
BACKGROUND : Chronic stress negatively affects health and well-being.
BACKGROUND : Circulating interleukin-6 levels increase with advancing age and are a risk factor for various diseases and mortality.
BACKGROUND : Circulating progenitor cells ( CPCs ) improve cardiovascular function and organ perfusion by enhancing the capacities of endothelial repair and neovasculogenesis.
BACKGROUND : Circulating trans fatty acids ( TFAs ) , which cannot be synthesized by humans , are linked to adverse health outcomes.
BACKGROUND : Clinical and biochemical predictors of extreme longevity would be useful in geriatric practice but have still not been clearly defined.
BACKGROUND : Clinical and epidemiological studies of older persons have implicated clusterin in Alzheimer's disease ( AD ) pathogenesis.
BACKGROUND : Clinical criteria are important for improving diagnostic accuracy and ensuring comparability of patient cohorts in research studies.
BACKGROUND : Clinical guidelines recommend using predicted atherosclerotic cardiovascular disease ( ASCVD ) risk to inform treatment decisions.
BACKGROUND : Clinicians frequently experience difficulty in eliciting the reflexes of elderly patients using standard methods due to paratonia / frontal rigidity.
BACKGROUND : Clinicopathological studies are important in determining the brain lesions underlying dementia.
BACKGROUND : Clopidogrel resistance is more common in patients with loss-of-function CYP2C19 genotypes.
BACKGROUND : Clostridium difficile infection has emerged as a major public health problem in the United States over the last @number@ decades.
BACKGROUND : Coarctation of the aorta is a congenital malformation that has long been considered completely correctable with appropriate surgery in childhood.
BACKGROUND : Coffee is a major dietary source of antioxidants as well as of other anti-inflammatory factors.
BACKGROUND : Cognitive decline contributes significantly to the safety risk of older drivers.
BACKGROUND : Cognitive decline in old age varies among individuals.
BACKGROUND : Cognitive decline is frequently observed in elderly patients after major surgery.
BACKGROUND : Cognitive decline is one of the most prominent healthcare issues of the 21st century.
BACKGROUND : Cognitive deterioration is a core symptom of many neuropsychiatric disorders and target of increasing significance for novel treatment strategies.
BACKGROUND : Cognitive function and telomere length both decline with age.
BACKGROUND : Cognitive impairment is an age-related condition as the rate of cognitive decline rapidly increases with aging.
BACKGROUND : Cognitive impairment is common among older people and is associated with increased morbidity and mortality.
BACKGROUND : Cognitive impairment is common among stroke survivors.
BACKGROUND : Cognitive impairment is common in patients treated with hemodialysis.
BACKGROUND : Cognitive impairment is often unrecognized among older adults.
BACKGROUND : Cognitive performance changes with chronological aging.
BACKGROUND : Color-Doppler ecocardiography and cardiopulmonary stress test are pivotal in the evaluation of patients with heart failure.
BACKGROUND : Colorectal cancer ( CRC ) is generally a disease of the older population.
BACKGROUND : Colorectal cancer ( CRC ) is the third most common diagnosed cancer in men and the second in women.
BACKGROUND : Colorectal cancer is the most common cancer in Germany.
BACKGROUND : Colorectal cancer is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related death globally.
BACKGROUND : Combination laser treatments can potentially increase the effectiveness of treatment without the additional downtime associated with another procedure.
BACKGROUND : Combination therapy with gemcitabine and docetaxel has been reported to be a good therapeutic strategy for patients with soft tissue sarcoma.
BACKGROUND : Combination treatment with toxins and fillers is the standard regimen in facial rejuvenation.
BACKGROUND : Communication about end of life care may involve difficult conversations for patients , family members and health professionals.
BACKGROUND : Communication between families and providers in the ICU affects patient and family outcomes and use of health-care resources.
BACKGROUND : Communication concepts relating to prevention and early intervention ( P & E ) within aesthetic medicine are poorly understood and highly underexplored.
BACKGROUND : Communication problems between family surrogates and intensive care unit ( ICU ) clinicians have been documented , but few interventions are effective.
BACKGROUND : Communication skills are recognized as tools for establishing relationships and accomplishing care related tasks.
BACKGROUND : Community-dwelling consumers of healthcare are increasing , many aging with life-limiting conditions and deteriorating cognition.
Background : Comorbidity indices that are based on clinically recognized disease do not capture the full spectrum of health.
BACKGROUND : Comorbid medical diseases are highly prevalent in the geriatric population , imposing hardship on healthcare services for demented individuals.
BACKGROUND : Comparatively few studies address the problems related to multimorbidity.
BACKGROUND : Compelling evidence has shown that the incidence of lumbar disc herniation ( LDH ) increases with age.
BACKGROUND : Compliance of the aorta is important in maintaining normal cardiovascular physiology.
BACKGROUND : Complicated Grief ( CG ) is a recently recognized bereavement-related mental health disorder.
BACKGROUND : Computed Tomography ( CT ) contributes up to @percent@ of the medical exposure to the United States population.
BACKGROUND : Concerns about polypharmacy and medication side effects contribute to undertreatment of geriatric pain.
BACKGROUND : Condylar and somatic growth have similar growth curves.
BACKGROUND : Conflicting results have been reported regarding the use of polarized microscopy as a predictive tool for human oocyte quality.
Background : Conflict in the family is a major risk factor for the well-being of older immigrants , whose lives are centered around their families.
BACKGROUND : Congenital human cytomegalovirus ( HCMV ) infection can result in lifelong neurological deficits.
BACKGROUND : Congestive heart failure ( CHF ) has become a major clinical and public health challenge with the aging of the population in China.
BACKGROUND : Consensus documents attribute the aging changes in BP to wave reflection moving progressively from diastole into systole.
BACKGROUND : Consequences of inappropriate prescriptions and polymedication in patients suffering from cancer are beginning to be well documented.
BACKGROUND : Considerable evidence indicates that diet is an important risk-modifying factor for Alzheimer's disease ( AD ) .
BACKGROUND : Consumer-driven homecare models support aging and disabled individuals to live independently through the services of homecare workers.
BACKGROUND CONTEXT : Clinicians regard lumbar lordotic curvature ( LLC ) with respect to low back pain ( LBP ) in a contradictory fashion.
BACKGROUND CONTEXT : Osteoporosis is a major health-care problem that is increasing in magnitude with the aging population.
BACKGROUND CONTEXT : Previous studies reported that the erector spinae muscle is more resistant to fatigue in healthy adult women than in men.
BACKGROUND CONTEXT : The ability to adequately measure a phenomenon is critical to studying and understanding it.
BACKGROUND : Continuous-flow left ventricular assist device ( LVAD ) has undergone dramatic change into strategy of treating severe heart failure.
BACKGROUND : Control beliefs are important psychological factors that likely contribute to heterogeneity in health outcomes for older adults.
BACKGROUND : Controversies exist regarding the association of androgenetic alopecia ( AGA ) with insulin resistance.
BACKGROUND : CO ( @number@ ) fractional ablation offers the potential for facial and non-facial skin resurfacing with minimal downtime and rapid recovery.
BACKGROUND : Coronary heart disease ( CHD ) is a leading cause of morbidity and mortality in African Americans.
BACKGROUND : Coronary spastic angina ( CSA ) is a common disease among East Asians , including Japanese.
BACKGROUND : Correct evaluation of orthostatic hypotension ( OH ) is crucial in geriatric practice , since OH is associated with mortality and morbidity.
BACKGROUND : Cosmetic procedures are growing ever more common , and the use of soft tissue fillers is increasing.
BACKGROUND : Cosmetic surgery and medicine are extremely interesting fields for a plastic surgeon.
BACKGROUND : Criteria for the clinical diagnosis of Alzheimer's disease ( AD ) were established in @number@
BACKGROUND : Critical care nurses have an integral role in supporting older patients and families faced with palliative care and EOL decision-making issues.
BACKGROUND : Critically ill patients frequently suffer muscle weakness whilst in critical care.
BACKGROUND : Cross-sectional research suggests social capital has negative consequences for problem drinking behaviors.
BACKGROUND : Cross-sectional studies have shown declines in lung function among refractory ceramic fibre ( RCF ) workers with increasing fibre exposure.
BACKGROUND : Cross-sectional studies suggest an association of 25-hydroxyvitamin D with exacerbations in patients with COPD , but longitudinal evidence from cohort studies is scarce.
BACKGROUND : Cryotherapy is a physiotherapy method used to treat back pain in older persons.
BACKGROUND : Curcumin is known to possess many anti-tumor properties such as inhibition of tumor growth and induction of apotosis.
BACKGROUND : Cured meat intake-a recent carcinogenic factor-may increase the risk of COPD , but its association with asthma remains unknown.
BACKGROUND : Current approaches for AD prediction are based on biomarkers , which are however of restricted availability in primary care.
BACKGROUND : Current data indicate that the size of high-density lipoprotein ( HDL ) may be considered an important marker for cardiovascular disease risk.
BACKGROUND : Current dementia medications have small effect sizes , many adverse effects and do not change the disease course.
BACKGROUND : Current guidelines consider that bariatric surgery is relatively contraindicated in elderly adults ( aged≥60 years ) .
BACKGROUND : Current HIV treatments are successful at suppressing plasma HIV RNA to undetectable levels for most adherent patients.
BACKGROUND : Currently , early weight-loss predictions of long-term weight-loss success rely on fixed percent-weight-loss thresholds.
BACKGROUND : Currently , little information describing the relationship of Pilates-based strength and stability exercises with fall risk in the geriatric population exists.
BACKGROUND : Currently , the face can be reshaped with minimally invasive procedures.
BACKGROUND : Currently , there are no appropriate RIs of blood cells available for the elderly in most clinical laboratories in China.
BACKGROUND : Currently , there is an increased prevalence of diabetes mellitus among the aging adult population.
BACKGROUND : Currently , there is not enough echocardiographic information regarding aging-associated changes in the octogenarian population.
BACKGROUND : Current , ongoing national surveys do not include questions about end-of-life ( EOL ) issues.
BACKGROUND : Current research fails to capture the temporal dynamics of chronic disease in favor of cross-sectional snapshots of symptoms and outcomes.
BACKGROUND : Current studies suggest an interaction between vascular mechanisms and neurodegenerative processes that leads to late-onset Alzheimer disease ( AD ) .
BACKGROUND : Current Swiss politics concerning age and ageing are orientated towards the principle \ "out-patient before in-patient \ ".
BACKGROUND : Cynicism develops in reaction to organisational events including leaders ' actions and can result in costly passive withdrawal behaviours.
BACKGROUND : Cytokine production and oxidative stress generated by ultraviolet radiation B ( UVB ) skin exposure are main factors of skin photoaging.
BACKGROUND : Daily habits , including the number and quality of eating occasions , are potential targets for primary prevention strategies with large health impacts.
BACKGROUND : Danon disease is an X-linked disorder that leads to fatal cardiomyopathy caused by a deficiency in lysosome-associated membrane protein-2 ( LAMP2 ) .
BACKGROUND : Data are limited on the presence , distribution , and extent of subclinical atherosclerosis in middle-aged populations.
BACKGROUND DATA : For non-thermal photorejuvenation , laser and LED light sources have been demonstrated to be safe and effective.
BACKGROUND : Data from the US indicates that methadone-maintained populations are aging , with an increase of patients aged @number@ or older.
BACKGROUND : Data on the prevalence of fecal incontinence in elderly patients admitted to outpatient clinics in Turkey are scarce.
BACKGROUND DATA : The pelvic incidence ( PI ) was recognized as the key factor of the sagittal balance of the spine.
BACKGROUND : Deactivation of the corrugator supercilii for the treatment of unintentional glabellar lines requires high selectivity to avoid sensory complications.
BACKGROUND : Deciding about undergoing prenatal screening is difficult , as it entails risks , potential loss and regrets , and challenges to personal values.
BACKGROUND : Decision boxes ( DBoxes ) are two-page evidence summaries to prepare clinicians for shared decision making ( SDM ) .
BACKGROUND : Decision support tools build upon comprehensive and timely syntheses of literature.
BACKGROUND : Decline of physical function with age is associated with substantial health consequences.
BACKGROUND : Declines in functional dependence among older adults were observed before the 1990s , but there is uncertainty about subsequent trends.
BACKGROUND : Declines in skeletal muscle mass and quality are important factors contributing to age-related weakness.
BACKGROUND : Declining muscle power during advancing age predicts falls and loss of independence.
BACKGROUND : Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state.
BACKGROUND : Decreased ability of muscles to respond to anabolic stimuli is part of the underlying mechanism for muscle loss with aging.
BACKGROUND : Decreased bone mineral density and osteoporosis in postmenopausal women represents a growing source of physical limitations and financial concerns in our aging population.
BACKGROUND : Decreases in functional ability due to aging can impair work capacity and productivity among older workers.
BACKGROUND : Decreases of strength and speed of muscle contraction are considered major causes of functional impairments in older people.
BACKGROUND : Decreasing physical mobility largely defines our idea of ageing.
BACKGROUND : Deep mining of healthcare data has provided maps of comorbidity relationships between diseases.
BACKGROUND : Default mode network ( DMN ) is vulnerable to the effects of APOE genotype.
BACKGROUND : Degenerative arthritis is a common and serious chronic illness that impacts the quality of life of older adults.
BACKGROUND : Degenerative changes of the cervical spine are an inevitable response to certain occupational status and aging processes.
BACKGROUND : Degenerative lumbar scoliosis ( DLS ) progresses with aging after 50-60 years , and the genetic association of DLS remains largely unclear.
BACKGROUND : Dehydroepiandrosterone sulfate ( DHEAS ) is important for its association with immune system function and health outcomes.
BACKGROUND Delayed cerebral ischemia ( DCI ) is one of the main causes of poor outcomes after subarachnoid hemorrhage ( SAH ) .
BACKGROUND : delays in diagnosing dementia may lead to suboptimal care , yet around half of those with dementia are undiagnosed.
BACKGROUND : Delineating the natural history of dementia progression has important clinical implications , including reducing caregiver burden and targeting effective drug trials.
BACKGROUND : Delirium , a common problem among hospitalized elderly patients , is not usually diagnosed by doctors for various reasons.
BACKGROUND : Delirium has been associated with negative health consequences , which can potentially be improved by delirium risk modification.
BACKGROUND : Delirium in hip fractured patients is a frequent complication.
BACKGROUND : Delirium is a common and serious postoperative complication.
BACKGROUND : delirium is a frequent neuropsychiatric syndrome affecting medical and surgical elderly patients.
BACKGROUND : Delirium is common , affecting at least @percent@ of older hospital inpatients.
BACKGROUND : Delirium is common , leads to other adverse outcomes , and is costly.
BACKGROUND : Delirium is increasingly considered to be an important determinant of trajectories of cognitive decline.
BACKGROUND : Delirium is the most frequent complication among older people following hospitalisation.
BACKGROUND : Delirium occurs frequently in the intensive care unit ( ICU ) , but its pathophysiology is still unclear.
BACKGROUND : Demand for aged care services continues to soar as a result of an aging population.
BACKGROUND : Demand for collagen-based fillers has declined primarily because of limited long-term clinical benefit and the introduction of hyaluronic acid compositions.
BACKGROUND : Dementia and mild cognitive impairment ( MCI ) are underrecognized in community settings.
BACKGROUND : Dementia caregiving is often associated with increase in depressive symptoms and strained relationships.
BACKGROUND : Dementia drug development aims to modulate pathological processes that cause clinical syndromes.
BACKGROUND : Dementia is a common and serious neuropsychiatric syndrome , characterised by progressive cognitive and functional decline.
BACKGROUND : Dementia is associated with disruptions in sleep and sleep quality for patients and their family caregivers.
BACKGROUND : Dementia is one of the most common diseases of aging and leads to an increased need for care.
BACKGROUND : Dementia is one of the most prevalent diseases in the older population.
BACKGROUND : Dementia research often requires the participation of people with dementia.
BACKGROUND : Dementia will inevitably increase in the aging world.
BACKGROUND : Dementia with Lewy bodies is one of the most prevalent dementia diagnoses.
BACKGROUND : Depression and depression-executive dysfunction syndrome ( DES ) are common neuropsychiatric consequences of stroke.
BACKGROUND : Depression and depressive symptoms are highly prevalent in old persons but are potentially reversible.
BACKGROUND : Depression and disability are closely linked.
BACKGROUND : Depression , if broadly defined , is the commonest late-life mental disorder.
BACKGROUND : Depression in late life is an important public health problem in developing countries.
BACKGROUND : Depression in persons with physical disabilities may be more common than in the general population.
BACKGROUND : Depression in tuberculosis increases the risk for adverse health outcomes.
BACKGROUND : Depression is a chronic mental health condition that affects millions of individuals worldwide.
BACKGROUND : Depression is a common and treatable illness in late-life.
Background : Depression is a major public health concern among older adults and health care professionals play a vital role in screening and treatment.
BACKGROUND : Depression is associated with an unusually high rate of aging-related illnesses and early mortality.
BACKGROUND : Depression is associated with increased mortality , but it is unclear if this relationship is truly causal.
BACKGROUND : Depression is associated with the metabolic syndrome ( MS ) .
Background : depression is associated with worse executive function , but underlying mechanisms might differ by age.
BACKGROUND : Depression is common in old age and is associated with risk of dementia , but its neuropathological correlates in the community are unknown.
BACKGROUND : depression is common in older people in general hospital settings and associated with poor outcomes.
BACKGROUND : Depression is currently underdiagnosed among older adults.
BACKGROUND : Depression is prevalent among patients with late life neurocognitive disorders but its role as an independent risk factor is not established.
BACKGROUND : Depression represents one of the most common psychiatric disorders among older adults.
BACKGROUND : Depression screening in chronic disease is advocated but its impact on routine practice is uncertain.
BACKGROUND : Depressive symptoms and depression are common in nursing home residents.
BACKGROUND : Depressive symptoms and physical performance are inversely associated , but it is unclear whether their association is bidirectional.
BACKGROUND : Depressive symptoms are common in older adults and associated with increased risk of cognitive impairment.
BACKGROUND : Dermal fillers are commonly injected in the lips for aesthetic treatment.
BACKGROUND : Dermal fillers are gaining popularity for rapid aesthetic improvement.
BACKGROUND : Dermal fillers have continuingly been under development to increase safety , efficacy , and longevity.
BACKGROUND : Despite a common misconception , older adults engage in sexual behavior.
BACKGROUND : Despite considerable efforts , a suitable vaccine against Onchocerca volvulus infection has remained elusive.
BACKGROUND : Despite extensive clinical experience with onabotulinumtoxinA , few data exist on patient satisfaction or safety with continuous treatment.
BACKGROUND : Despite extensive research funding in the field of dementia , deficits in the quality of dementia care still exist.
BACKGROUND : Despite improved survival , childhood cancer survivors experience significantly elevated risk of premature mortality and serious morbidity due to chronic health conditions.
BACKGROUND : Despite mounting evidence that principles of palliative care are appropriate in care for individuals with dementia they are often not applied.
BACKGROUND : Despite recent progress in treatments for secondary prevention , ischemic stroke recurs in @percent@ to @percent@ of stroke survivors.
BACKGROUND : Despite the focus on facial photoaging ratings , there are few classifications developed for forearm skin aging assessment.
BACKGROUND : Despite the high prevalence of rotator cuff disease in the aging adult population , the basic mechanisms initiating the disease are not known.
BACKGROUND : Despite the increasing burden of dementia in developing countries , mild cognitive impairment ( MCI ) continues to be underexplored.
BACKGROUND : Despite the increasing numbers of reverse total shoulder arthroplasty ( RTSA ) procedures , the long-term results have been rarely reported.
BACKGROUND : Despite the widely accepted concept that probiotics confer miscellaneous benefits to hosts , the controversies surrounding these health-promoting claims cannot be ignored.
BACKGROUND : Despite treatment with virologically suppressive antiretroviral therapy ( ART ) , neurocognitive impairment may persist or develop de novo in aging HIV-infected individuals.
BACKGROUND : Despite wide-spread use of antihypertensives in older adults , the literature is unclear about their association with incident recurrent falls over time.
BACKGROUND : Despite widespread use of multivitamin supplements , their effect on cognitive health-a critical issue with aging-remains inconclusive.
BACKGROUND : detecting chronic kidney disease ( CKD ) may have important implications for the management of older and frail people.
BACKGROUND : Deterioration in hearing after Gamma Knife radiosurgery of vestibular schwannomas is a well-documented risk.
BACKGROUND : Developing interventions to prevent frailty in older adults is a priority as it increases the risk for disability , institutionalization , and death.
BACKGROUND : Development of oral narrative.
BACKGROUND : Developments in data collection technology enable evaluation of kinematic characteristics of the drawing process.
BACKGROUND : Diabetes is associated with a high incidence of macrovascular disease ( MVD ) , including peripheral and coronary artery disease.
BACKGROUND : Diabetes is associated with decreased muscle mass.
BACKGROUND : Diabetes mellitus ( DM ) is highly prevalent and increasing in geriatric population.
BACKGROUND : Dialysis patients suffer from a high burden of cardiovascular disease ( CVD ) .
BACKGROUND : Dietary antioxidants can inhibit reactions accompanying neurodegeneration and thus prevent cognitive impairment.
BACKGROUND : Dietary fiber may decrease the risk of cardiovascular disease and associated risk factors.
BACKGROUND : Dietary patterns can be identified by a priori and a posterior approaches.
BACKGROUND : Dietary patterns can be identified using a priori and a posterior approaches.
BACKGROUND : Dietary supplements are used by one-third of children.
BACKGROUND : Dietary supplement use is common in older adults.
BACKGROUND : Diet is a modifiable factor that could be targeted as an appropriate intervention to optimise cognitive health and well-being in ageing.
BACKGROUND : Different characteristics of foot morphology are commonly accompanied by altering lower extremity biomechanical characteristics and foot function.
BACKGROUND : Different conditions in health services utilization may create situations of inequity.
BACKGROUND : Different techniques have been used for filler injection of the tear trough and palpebromalar groove.
Background : Difficulties with daily functioning are common in middle-aged adults.
BACKGROUND : Difficulties with performance of functional activities may result from cognitive and / or physical impairments.
BACKGROUND : Diffusion tensor imaging can evaluate white matter function in human brain.
BACKGROUND : Dilated cardiomyopathy ( DCM ) is a heart muscle disease with cardiac dysfunction and a heterogeneous disorder.
BACKGROUND : Diminished control of standing balance , traditionally indicated by greater postural sway magnitude and speed , is associated with falls in older adults.
BACKGROUND : Direct antiviral agent ( DAA ) has been the standard of care for patients with hepatitis C virus ( HCV ) infection.
BACKGROUND : Disability , functionality , and morbidity are often used to describe the health of the elderly.
BACKGROUND : Disability in activities of daily living is a growing concern among older populations all over the world.
BACKGROUND : Disability prevalence in older adults is increasing.
BACKGROUND : Discrepancies have been reported in the prevalence rate of restless legs syndrome ( RLS ) among different ethnic groups and geographic populations.
Background : Discrimination is part of life for many Americans , especially ethnic minorities.
BACKGROUND : Disinfectant use among healthcare workers has been associated with respiratory disorders , especially asthma.
BACKGROUND : Disparities in access to kidney transplantation ( KT ) remain inadequately understood and addressed.
BACKGROUND : Dispositional optimism , defined as a generalized tendency to positive outcome expectancies , is associated with well-being and successful aging.
BACKGROUND : Disruption in normal development of the human prefrontal cortex ( PFC ) may lead to cognitive dysfunction that manifests in individuals with schizophrenia.
BACKGROUND : Disulfide bonds are traditionally considered to play only structural roles.
BACKGROUND : Diurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus.
BACKGROUND : Diverticular disease of the colon also affects older people.
BACKGROUND : Dizziness is a common symptom in older adults.
BACKGROUND : DNA methylation changes at a discrete set of sites in the human genome are predictive of chronological and biological age.
BACKGROUND : DNA methylation is a potential pathway linking environmental exposures to disease.
BACKGROUND : DNA methylation levels change with age.
BACKGROUND : DNA methylation of promoter-associated CpG islands of certain genes may play a role in the development of colorectal cancer.
BACKGROUND : Downhill skiing is part of active life style in many residents of Alpine regions.
BACKGROUND : Down syndrome ( DS ) is caused by trisomy of all or part of chromosome @number@
BACKGROUND : Downward shifts in blood volume with changing position generally cause tachycardic responses.
BACKGROUND : Driving cessation can lead to negative consequences , such as depression and reduced social activities.
Background Drug interactions ( DIs ) are a significant cause of medication-related problems.
BACKGROUND : Drug is an important part of disease treatment , but medication errors happen frequently and have significant clinical and financial consequences.
BACKGROUND : Drug-related problems are an important healthcare safety concern in the growing population of older people.
BACKGROUND : Dual chamber pacing is known to have detrimental effect on cardiac performance and heart failure occurring eventually is associated with increased mortality.
BACKGROUND : Due to current demographic trends , the prevalence of mild cognitive impairment and dementia is expected to increase considerably.
BACKGROUND : Due to demographic aging , an increasing number of revision arthroplasty procedures is expected during upcoming years.
BACKGROUND : Due to demographic change , the advanced elderly represent the fastest growing population group in Europe.
BACKGROUND : Due to its strong water binding potential , hyaluronic acid ( HA ) is a well-known active ingredient for cosmetic applications.
BACKGROUND : Due to population aging , an increasing number of elderly patients with diabetes use insulin.
BACKGROUND : Due to the aging of the population , society includes a growing proportion of older individuals prone to chronic morbidity.
BACKGROUND : Due to the aging of the population , the number of older patients diagnosed with a malignant disease is increasing.
BACKGROUND : Due to the aging population , there is an increase in the number of elderly patients with asthma.
BACKGROUND : During its @number@ days sojourn in the circulation , the red blood cell ( RBC ) remodels its membrane.
BACKGROUND : During organismal aging , human T-cells shift towards less functional phenotypes , often called senescent cells.
BACKGROUND : During senescence , despite the loss of strength ( force-generating capability ) associated with sarcopenia , muscle endurance may improve for isometric contractions.
BACKGROUND : During the last years we have always found an increase of antibiotic resistance.
Background Dutasteride has been successfully used in treatment of lower urinary tract symptoms ( LUTS ) secondary to benign prostatic hyperplasia ( BPH ) .
BACKGROUND : Dynamic contrast-enhanced magnetic resonance imaging ( DCE-MRI ) is a potentially powerful tool for analysis of kidney structure and function.
BACKGROUND : Dysfunction of the meibomian gland ( MG ) is among the most frequent causes of ophthalmological symptoms.
BACKGROUND : Dyslipidemia is an important global health problem , particularly in the elderly population.
BACKGROUND : Early identification of treatment failure for nosocomial pneumonia remains a major challenge.
BACKGROUND : Early-onset hearing loss is mostly of genetic origin.
BACKGROUND : Edentulism affects the quality of life and general health of an individual.
BACKGROUND : Educational attainment may be an important determinant of life expectancy.
BACKGROUND : Effective antiretroviral therapy has reduced the risk of AIDS and dramatically prolonged the survival of HIV-infected people in the United States.
BACKGROUND : Effective communication between residents with dementia and care providers in long-term care homes ( LTCHs ) is essential to resident-centered care.
BACKGROUND : Effective nonablative skin tightening has become a reality.
BACKGROUND : Effective pain management is an important component of aesthetic procedures.
BACKGROUND : Effective use of experimental pain in research depends on a thorough understanding of factors influencing their use.
BACKGROUND : Elder abuse and metabolic syndromes are both important public health issues and are associated with increased morbidity and mortality.
Background : Elder abuse ( EA ) is a global public health issue.
BACKGROUND : Elder abuse is a pervasive human right and public health issue.
BACKGROUND : Elderly adults have comprised the fastest growing population adopting the Internet and computer technology over the past decade.
BACKGROUND : Elderly patients admitted to Geriatric Assessment Units ( GAU ) typically have complex health problems that require multi-professional care.
BACKGROUND : Elderly patients undergoing oncological surgery experience postoperative cognitive decline.
BACKGROUND : Elderly patients with multiple morbidities and polypharmacy are at an increased risk of adverse drug events ( ADEs ) .
BACKGROUND : Elderly patients with rheumatoid arthritis ( RA ) have more aging-related complications than nonelderly patients with RA.
BACKGROUND : Elderly people are less able to manipulate objects skilfully than young adults.
BACKGROUND : Elderly people , particularly those with dementia , are sensitive to adverse anticholinergic drug effects.
BACKGROUND : Elderly persons have the highest rates of tuberculosis ( TB ) in the United States compared to all other age groups.
BACKGROUND : Elderly polypharmacy patients may be more at risk of not adhering to medication.
BACKGROUND : Elder mistreatment ( EM ) is a pervasive public health issue and is associated with morbidity and premature mortality.
Background : Elder mistreatment ( EM ) prevalence varies greatly according to definitional criteria.
BACKGROUND : E-learning is an efficient and cost-effective educational method.
BACKGROUND : Electrocardiography ( ECG ) , predictive of adverse outcomes in the general population , has not been studied in cancer survivors.
BACKGROUND : Elevated B-type natriuretic peptide ( BNP ) levels are associated with heart failure and increased mortality in the general population.
BACKGROUND : Elevated homocysteine levels are a risk indicator for cardiovascular disease , fractures and cognitive decline.
BACKGROUND : Elevated plasma homocysteine concentrations have been associated with both cognitive impairment and dementia.
BACKGROUND : Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors.
BACKGROUND : Emergency department ( ED ) visits for ambulatory care sensitive conditions ( ACSCs ) are common among older adults.
BACKGROUND : Emergency room ( ER ) visits and hospitalizations of elderly subjects with chronic comorbidities , often disabled , are increasing.
BACKGROUND : Emerging evidence suggests that arterial stiffness , an important marker of cardiovascular health , is associated with alcohol consumption.
BACKGROUND : Emerging health care reform initiatives are of growing importance amidst concerns about providing care to increasing numbers of adults with multiple chronic conditions.
BACKGROUND : Employer-based retiree drug benefits have long been viewed as the gold standard of drug coverage for elderly Medicare beneficiaries.
BACKGROUND : Endothelial cell damage and glycocalyx shedding after trauma can increase the risk of inflammation , coagulopathy , vascular permeability , and death.
BACKGROUND : Endothelial colony-forming cells ( ECFC ) are endowed with vascular regenerative ability in vivo and in vitro.
BACKGROUND : Endovascular angioplasty and stent placement is currently the most frequent treatment for iliac artery occlusive disease.
BACKGROUND : Energy deficiency and mitochondrial failure have been recognized as a prominent , early event in Alzheimer's disease ( AD ) .
BACKGROUND : Enhanced platelet activation has been implicated in several pathophysiological processes.
BACKGROUND : Environmental and lifestyle factors regulate the expression and release of immune mediators.
BACKGROUND : Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.
BACKGROUND : Epidemiological studies have shown the prevention of cardiovascular diseases through the regular consumption of vegetables.
BACKGROUND : Epidemiologic studies on mild cognitive impairment ( MCI ) are limited in China.
BACKGROUND : Epidermal and fibroblast growth factor ( EGF and FGF1 ) proteins play an important role in the regeneration and proliferation of skin cells.
BACKGROUND : Epidural analgesia is considered fundamental in enhanced recovery protocols ( ERPs ) .
BACKGROUND : Epigenetic features such as DNA hypomethylation have been associated with conditions related to cardiovascular risk.
BACKGROUND : Epigenetic mechanisms might be involved in the regulation of interindividual lipid level variability and thus may contribute to the cardiovascular risk profile.
BACKGROUND : Epigenetics is the study of processes beyond DNA sequence alteration producing heritable characteristics.
BACKGROUND : Epigenome-wide association studies of human disease and other quantitative traits are becoming increasingly common.
BACKGROUND : Episodic memory ( EM ) declines with age and the rate of decline is variable across individuals.
BACKGROUND : Erectile dysfunction ( ED ) is common in older men with chronic kidney disease.
BACKGROUND : Essential tremor ( ET ) , a highly-prevalent , progressive , aging-associated neurological disease , poses a significant public health challenge.
BACKGROUND : Estimates of hippocampal volume by magnetic resonance imaging have clinical and cognitive correlations and can assist in early Alzheimer disease diagnosis.
BACKGROUND : Estrogen and testosterone may influence cognitive function in the older adult , but the relationship between sex hormones and cognitive function is complex.
BACKGROUND : Ethical values and morals are important aspects that influence the quality of care.
BACKGROUND : Ethnic disparities in cardiovascular morbidity and mortality are widely documented in the literature.
BACKGROUND : Etiologic differences in mild cognitive impairment ( MCI ) subtypes may impact mortality.
BACKGROUND : Eukaryotic elongation factor @number@ alpha-2 ( eEF1A2 ) has been recently shown to be a putative oncogene of lung cancer.
BACKGROUND : Even with healthy and active aging , many older adults will experience a decrease in physical capacities.
Background : Evidence highlights the importance of muscular strength as a protective factor for health and function across aging populations.
BACKGROUND : Evidence suggests a possible bidirectional connection between cardiovascular disease ( CVD ) and the frailty syndrome in older people.
BACKGROUND : Evidence suggests that gait is influenced by higher order cognitive and cortical control mechanisms.
BACKGROUND : Evidence supports the role for mitochondrial impairment in the pathophysiology of bipolar disorder ( BD ) .
BACKGROUND : Evidence to guide primary prevention in adults aged @number@ years or older is limited.
BACKGROUND : Ewing sarcoma survivors ( ESSs ) are at increased risk for treatment-related complications.
BACKGROUND : Examination of linked data on patient outcomes and cost of care may help identify areas where stroke care can be improved.
BACKGROUND : Examine the independent and joint effects of geriatric syndromes ( GS ) and cardiometabolic diseases ( CMDs ) on functional impairment.
BACKGROUND : Exceptional aging , defined as reaching age @number@ years , shows geographic inequalities that may depend on local environmental conditions.
BACKGROUND : Excess adiposity gains and significant lean mass loss may be risk factors for chronic disease in old age.
BACKGROUND : Excessive workload for nurses may lead to poor quality of care and high nursing turnover rates.
BACKGROUND : Excess weight is a major threat to public health.
BACKGROUND : excess weight is a risk factor for numerous co-morbidities that predominantly occur in later life.
BACKGROUND : Exercise exerts remarkably powerful effects on metabolism and health , with anti-disease and anti-aging outcomes.
BACKGROUND : Exercise has been shown to be effective in cardiovascular endurance in the elderly.
BACKGROUND : Exercise programs that challenge an individual's balance have been shown to reduce the risk of falls among older adults.
BACKGROUND : Exercise training has been demonstrated to enhance physical function and to have a protective effect against functional limitations and disability in older adults.
BACKGROUND : Exercise training is considered an effective strategy to improve metabolic disease.
BACKGROUND : Exercising , including dancing , has been recommended to improve cardiovascular health of older people.
BACKGROUND : Existing methodological challenges in aging research has dampened our assessment of cognitive function among minority older adults.
BACKGROUND : Expenditure on medications for highly prevalent chronic conditions such as diabetes mellitus ( DM ) can result in financial impoverishment.
BACKGROUND : Experiences of discrimination are detrimental to health and well-being.
BACKGROUND : Experimentalists are overwhelmed by high-throughput data and there is an urgent need to condense information into simple hypotheses.
BACKGROUND : Experimentally induced sleep deprivation can raise blood pressure ( BP ) and worsen hypertension.
BACKGROUND : Exposure to traffic-related air pollution ( TRAP ) contributes to increased cardiovascular risk.
BACKGROUND : External assistance can rapidly strengthen health programmes in developing countries , but such funding can also create sustainability challenges.
BACKGROUND : Face-lift surgery when combined with perioral phenol-croton oil peel is an underappreciated tool for face rejuvenation.
BACKGROUND : Facial aging involves changes in the facial skeleton and soft tissues.
BACKGROUND : Facial aging is a dynamic process involving the aging of soft-tissue and bony structures.
BACKGROUND : Facial aging is a dynamic process with impact on both the soft tissues and the bones.
BACKGROUND : Facial appearance has profound influence on the first impression that is projected to others.
BACKGROUND : Facial lines or wrinkles are among the most visible signs of aging , and minimally invasive cosmetic procedures are becoming increasingly popular.
BACKGROUND : Facial rejuvenation continues to be an increasing trend among males.
Background : Facial rejuvenation in patients younger than @number@ years of age has experienced an unprecedented growth with multimodality nonsurgical and less invasive rhytidectomy techniques.
BACKGROUND : Facial \ "rejuvenation \ " procedures make an implicit claim to provide a more youthful appearance.
BACKGROUND : Facial sagging is a well-known morphological feature associated with aging and reduced dermal elasticity.
BACKGROUND : Facial skin pores ( FSP ) are common and benign signs that generate frequent esthetic concerns or complaints.
BACKGROUND : Faecal occult blood tests ( FOBTs ) are used for colorectal cancer ( CRC ) screening.
BACKGROUND : Fall incidents are a major cause of morbidity and mortality in older adults.
BACKGROUND : Falling is a common but devastating and costly problem of aging.
BACKGROUND : Fall prevention interventions for community-dwelling older adults have been found to reduce falls in some research studies.
BACKGROUND : Fall-related injuries associated with aging are a serious clinical and economic problem.
BACKGROUND : Falls affect approximately one third of community-dwelling older adults each year and have serious health and social consequences.
BACKGROUND : Falls among older adults is one of the major public health challenges facing the rapidly changing demography.
BACKGROUND : Falls and chronic disease are both important health issues in older adults.
BACKGROUND : Falls and fractures are among the principal causes of disability , and mortality of older people.
BACKGROUND : Falls are a ' geriatric giant ' and are the third leading cause of chronic disability worldwide.
BACKGROUND : Falls are a leading cause of preventable hospitalizations from long-term care facilities ( LTCFs ) .
BACKGROUND : Falls are a major public health concern among older adults , and most occur while walking , especially under dualtask conditions.
BACKGROUND : Falls are common in older people and are associated with substantial health-care costs.
BACKGROUND : Falls are common in the elderly , especially in those with cognitive impairment.
BACKGROUND : Falls are the leading cause of traumatic brain injury and fractures and the No. @number@ cause of emergency department visits by older adults.
BACKGROUND : Falls in the elderly is nowadays a major concern because of their consequences on elderly general health and moral states.
BACKGROUND : Falls of individuals with dementia are frequent , dangerous , and costly.
BACKGROUND : Falls remain the leading cause of injury , long-term disability , premature institutionalization , and injury-related mortality in the older adult population.
BACKGROUND : Familial breast cancers are known to be of early onset.
BACKGROUND : Familial spastic paraplegia ( FSP ) is a heterogeneous group of disorders characterized primarily by progressive lower limb spasticity and weakness.
BACKGROUND : Family caregivers of people with dementia have significant unmet needs in regard to their caregiving role.
BACKGROUND : Fatigue is reported as one of the most disabling symptoms and is common among persons living with late effects of polio.
BACKGROUND : Fat infiltration within skeletal muscle is known as intramuscular fat ( IMF ) , which increases with aging.
BACKGROUND : fear of falling ( FOF ) is common in older people and associated with serious physical and psychosocial consequences.
BACKGROUND : Fear of falling has been linked to activity restriction , functional decline , decreased quality of life and increased risk of falling.
BACKGROUND : Fear of recurrence ( FoR ) is a widespread problem among breast cancer survivors.
BACKGROUND : Ferritin constitutes a sensitive iron-storage index and multi-functional protein.
BACKGROUND : Fetal exposure to maternal smoking is associated with an adverse cardiovascular risk profile in later life.
BACKGROUND : Few comparisons exist of the quality of primary care provided by nurse practitioners ( NPs ) versus physicians.
BACKGROUND : Few data exist on the ability of postmenopausal women to absorb calcium from diets habitually low in calcium.
BACKGROUND : Few data have been acquired on the predictive value of age-related T-lymphocyte subsets among older individuals.
BACKGROUND : Few dosing data on onabotulinumtoxinA to treat hyperdynamic perioral lines ( POLs ) are available.
BACKGROUND : Few electroencephalography ( EEG ) data are available in anaesthetized infants.
BACKGROUND : Fewer than @percent@ of persons with hypertension in the United States have adequate blood pressure ( BP ) control.
BACKGROUND : Few facelift methods are designed specifically for Asian patients.
BACKGROUND : Few published data link overweight and obesity with measures of quality of life ( QoL ) including sexual health in men.
BACKGROUND : Few scientific studies have examined movement-based embodied contemplative practices such as yoga and their effects on cognition.
BACKGROUND : Few studies describe oral anticoagulant ( OAC ) prescription practices in very elderly patients with atrial fibrillation ( AF ) .
BACKGROUND : Few studies have evaluated the association between anticholinergic use and mortality in elderly nursing home residents.
BACKGROUND : Few studies have evaluated the association between incident chronic kidney disease ( CKD ) and related complications , especially in elderly population.
BACKGROUND : Few studies have examined how dementia and comorbidities may interact to affect healthcare expenditures.
BACKGROUND : Few studies have examined the associations among family , friend , and coworker social support for physical activity.
BACKGROUND : Few studies have explored the risk factors of sarcopenia in certain cohorts.
BACKGROUND : Few studies have investigated the impact of urinary incontinence ( UI ) on health-related quality of life ( HRQOL ) among cancer survivors.
BACKGROUND : Few studies have investigated the long-term effect of overall nutritional recommendations on cognition.
BACKGROUND : Few studies on fall risk factors use long-recommended methods for analysis of recurrent events.
BACKGROUND : Fiber intake is associated with lower cardiovascular disease risk.
BACKGROUND : Fibroblasts are key players in maintaining skin homeostasis and in orchestrating physiological tissue repair and skin regeneration.
BACKGROUND : Fibromyalgia is a condition which involves chronic pain.
BACKGROUND : Finding ways to optimise health in older age is key to reducing the impact of population ageing on health and social care systems.
BACKGROUND : Flow-mediated dilation ( FMD ) following reactive hyperaemia can use different time-point measures for baseline diameter.
BACKGROUND : Fluctuations in the national economy shape labour market opportunities and outcomes , which in turn may influence the accumulation of cognitive reserve.
BACKGROUND : Flupirtine is a nonopioid , central analgesic without antipyretic or antiphlogistic properties.
BACKGROUND : Foot and ankle ( FA ) exercise programs might reduce the risk of falling in older adults.
BACKGROUND : Foot pain and related disability in older adults are common yet understudied problems.
BACKGROUND : Forces acting in facial skin have been suggested to show directionality.
BACKGROUND : Forehead and glabella rhytides are treated mostly with neurotoxins , although some practitioners prefer the concurrent use of fillers.
BACKGROUND : For nursing home patients , hospice use and associated costs have grown dramatically.
BACKGROUND : For the glabellar region , severe partly vascular adverse events have been reported after treatment with injectable fillers.
BACKGROUND : For the last decade , there has been a shortage of pharmacists for most of the United States.
BACKGROUND : For the past several decades , the U.S. prison system has witnessed a steady and persistent increase in the ages of prison populations.
BACKGROUND : Four previously reported studies have tested for association of blood proteins with neocortical amyloid-β burden ( NAB ) .
BACKGROUND : Fractional CO2 -laser resurfacing is increasingly used for treating rhytides and photoaged skin because of its favorable benefit-risk ratio.
BACKGROUND : Fractional lasers were introduced to provide increased safety , while maintaining high efficacy and patient satisfaction.
BACKGROUND : Fractional photothermolysis is a novel aesthetic-laser-surgical modality for the treatment of facial wrinkle in Caucasians apart from other conventional treatments.
BACKGROUND : Fractional resurfacing is a new laser treatment used mainly for treating photoaging and acne scars.
BACKGROUND : Fracture of the hip ( HF ) is a significant cause of morbidity and mortality in elderly individuals.
BACKGROUND : Fractures of the talus in the elderly are rare and usually result from high-impact injuries , suggesting only minor age-related bone structure changes.
BACKGROUND : Fragility fractures of the proximal humerus and distal radius can have a significant impact on the elderly population , both economically and physically.
BACKGROUND : Frail older adults are heavy users of health and social care.
BACKGROUND : Frail older people are at high risk of developing adverse outcomes , such as disability , mortality , hospitalization , and institutionalization.
BACKGROUND : frail older people have a high risk of falling.
BACKGROUND : Frailty , an age-related state of increased vulnerability , is associated with a higher risk of multiple adverse events.
BACKGROUND : Frailty assessment provides a means of identifying older adults most vulnerable to adverse outcomes.
Background : Frailty confers risk for surgical morbidity and mortality.
BACKGROUND : Frailty , defined as a biologic syndrome of decreased reserve and resistance to stressors , has been linked to adverse outcomes after surgery.
BACKGROUND : Frailty has become a high-priority issue in cardiovascular medicine because of the aging of cardiovascular patients.
BACKGROUND : Frailty has been considered an antecedent and , to a lesser extent , an outcome of cognitive impairment.
BACKGROUND : Frailty has emerged as a key medical syndrome predictive of comorbidity , disability , institutionalization and death.
BACKGROUND : Frailty in individuals can be operationalized as the accumulation of health deficits , for which several trends have been observed in Western countries.
BACKGROUND : Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems.
BACKGROUND : Frailty is a health condition related to aging and dependence.
Background : Frailty is an age-related clinical syndrome of decreased resilience to stressors and is associated with numerous adverse outcomes.
BACKGROUND : Frailty is an aging syndrome caused by exceeding a threshold of decline across multiple organ systems leading to a decreased resistance to stressors.
BACKGROUND : frailty is an important geriatric syndrome linked to increased mortality , morbidity and falls risk.
BACKGROUND : Frailty is associated with adverse health outcomes , but its association with hospital healthcare costs has not been analyzed.
Background : frailty is associated with an increased risk of fragility fractures.
BACKGROUND : frailty is a state of vulnerability to adverse outcomes.
BACKGROUND : Frailty is common in the elderly and is associated with adverse health outcomes.
BACKGROUND : Frailty is related to adverse outcomes in the elderly.
BACKGROUND : Frailty renders older individuals more prone to adverse health outcomes.
BACKGROUND : Frailty syndrome ( FS ) is an important problem in older persons.
BACKGROUND : Frailty syndrome ( FS ) is a well-established predictor of outcomes in geriatric patients.
BACKGROUND : Frank's sign was first described in @number@ by an American physician ( Sonders T. Frank ) .
BACKGROUND : Fried and colleagues described a frailty phenotype measured in the Cardiovascular Health Study ( CHS ) .
BACKGROUND : Friedreich ataxia ( FRDA ) is the commonest form of autosomal recessive ataxia.
BACKGROUND : Frontotemporal dementia ( FTD ) is characterised clinically by progressive changes in behaviour and personality ; these changes are followed by cognitive disorder.
BACKGROUND : Frontotemporal dementia is a highly heritable neurodegenerative disorder.
BACKGROUND : Fructose intake has been increased steadily during the past two decades.
BACKGROUND : Functional connectivity MRI is an emerging technique that can be used to investigate typical and atypical brain function in developing and aging populations.
BACKGROUND : Functional decline ( FD ) is a largely preventable feature of aging , characterized as gradual erosion of functional autonomy.
BACKGROUND : Functional decline in stem cell-mediated regeneration contributes to aging associated with cellular senescence in c-kit + cardiac progenitor cells ( CPCs ) .
BACKGROUND : Functional independence with aging is an important goal for individuals and society.
BACKGROUND : Fungi can cause a variety of infectious diseases , including invasive mycosis and non-invasive mycosis , as well as allergic diseases.
BACKGROUND : Gait and cognition are closely associated.
BACKGROUND : Gait and cognitive disturbances are common in Parkinson's disease ( PD ) .
BACKGROUND : Gait characteristics measured at usual pace may allow profiling in patients with cognitive problems.
BACKGROUND : Gait impairment is common in parkinsonian syndromes but not specific to striatonigral dysfunction.
BACKGROUND : Gait patterns of healthy aging are needed to allow a comparison with pathological situations.
BACKGROUND : Gait speed provides an integrated measure of physical ability that is predictive of morbidity , disability , and mortality in older adults.
BACKGROUND : Gal-3 is implicated in the pathogenesis of cardiac fibrosis but is also increased with normal aging and renal dysfunction.
BACKGROUND : Gastric cancer ( GC ) is the second-leading cause of cancer-related deaths worldwide , with overall 5-year survival less than @percent@.
BACKGROUND : Gastrointestinal complications from antibiotic use , including Clostridium difficile infection ( CDI ) , can have significant morbidity , especially among older patients.
BACKGROUND : Gastro-oesophageal reflux disease ( GERD ) is thought to become more prevalent with age.
BACKGROUND : Gender differences in orthostatic tolerance in the elderly are poorly studied and understood.
BACKGROUND : Generalized anxiety disorder ( GAD ) peaks in prevalence in middle age and declines in prevalence into old age.
BACKGROUND : general opinion is growing that drug cessation in complex older patients is warranted in certain situations.
BACKGROUND : Genes involved in the IGF-1 aging pathways in the human ovary can be considered strong candidates for predictors of the natural menopause timing.
BACKGROUND : Genome-wide association studies ( GWAS ) for Parkinson's disease have linked two loci ( MAPT and SNCA ) to risk of Parkinson's disease.
BACKGROUND : Genome-wide association studies ( GWAS ) have discovered genetic variants that predispose individuals to asthma.
BACKGROUND : Genome-wide association studies ( GWAS ) have identified common genetic variants that predispose to atrial fibrillation ( AF ) .
BACKGROUND : Genome-wide association studies have identified novel genetic associations for asthma , but without taking into account the role of active tobacco smoking.
BACKGROUND : Genome-wide association studies have identified several single nucleotide polymorphisms ( SNPs ) that are associated with risk of colorectal cancer.
BACKGROUND : Genomewide association studies of autoimmune diseases have mapped hundreds of susceptibility regions in the genome.
BACKGROUND : Genome-wide expression profiles are altered during biological aging and can describe molecular regulation of tissue degeneration.
BACKGROUND : Genome-wide gene expression profiling of mammalian cells is becoming a staple of many published biomedical and biological research studies.
BACKGROUND : Geriatric patients with femoral neck fracture ( FNF ) have unacceptably high rates of postoperative complications and mortality.
BACKGROUND : Gerontological research aims at understanding factors that are crucial for mediating \ "successful aging \ ".
BACKGROUND : Gerontology research shows the importance of physical exercise for active aging.
BACKGROUND : Gestational diabetes is a risk factor for perinatal complications ; include shoulder dystocia , birth injuries such as bone fractures and nerve palsies.
BACKGROUND : Given our aging population , patients with an intrathoracic stomach are an increasing clinical problem.
BACKGROUND : Glaucoma is the second leading cause of blindness worldwide and is usually diagnosed in higher age groups.
BACKGROUND : Glaucoma is the World's leading cause of irreversible blindness , and poses serious public health and economic concerns.
BACKGROUND : Global but predictable changes impact the DNA methylome as we age , acting as a type of molecular clock.
BACKGROUND : Global genomic hypomethylation is a common epigenetic event in cancer that mostly results from hypomethylation of repetitive DNA elements.
BACKGROUND : Global glomerulosclerosis is characteristic of chronic kidney disease and also occurs with normal aging.
BACKGROUND : Globally , national health systems are challenged to build successful aging models to prepare for biomedical , psychological and social changes.
BACKGROUND : Globally , suicide rates increase with age , being highest in older adults.
BACKGROUND : Globally the older population is increasing rapidly.
BACKGROUND : Global population aging will result in increasing rates of cognitive decline and dementia.
BACKGROUND : Glomerular filtration rate ( GFR ) is directly associated with survival.
BACKGROUND : Glutamate receptor @number@ metabotropic ( GRM4 ) expression is increased in the brain of patients with depression.
BACKGROUND : Glutathione-S-transferase gene ( GST ) polymorphisms can result in variable ability of these enzymes to remove electrophilic substrates.
BACKGROUND : Glutathione S-transferase omega-1 and @number@ have a unique range of enzymatic activities , including the regeneration of ascorbate by their dehydroascorbate reductase activities.
BACKGROUND : Glycated hemoglobin ( HbA1c ) is used to diagnose type @number@ diabetes ( T2D ) and assess glycemic control in patients with diabetes.
BACKGROUND : Goal directed fluid therapy ( GDFT ) has been shown to improve outcomes in moderate to high-risk surgery.
BACKGROUND : Greater ambulatory blood pressure variability ( ABPV ) is associated with end-organ damage and increased mortality.
BACKGROUND : Greater educational attainment is associated with better neurocognitive health in older adults and is thought to reflect a measure of cognitive reserve.
BACKGROUND : Greater muscle mass can generally produce greater muscle strength.
BACKGROUND : Great heterogeneity exists in survival and the interval between onset of motor symptoms and dementia symptoms across synucleinopathies.
BACKGROUND : Group reminiscence therapy is a brief and structured intervention in which participants share personal past events with peers.
BACKGROUND : Growing evidence suggests that oral health may be an important factor associated with cognitive function in aged populations.
Background : Growing evidence supports the existence of neurobiological trait abnormalities in individuals at genetic risk for bipolar disorder.
BACKGROUND : Growing old involves many changes in life and implies an increased risks of illness and different forms of disabilities.
BACKGROUND : Growth failure is associated with adverse consequences , but studies need to control adequately for confounding.
BACKGROUND : Guidelines for the prevention of intravascular catheter-related infections are an important tool to help healthcare professionals minimise the risk of infection.
BACKGROUND : Guillain-Barré syndrome ( GBS ) is an acute inflammatory polyneuropathy resulting in demyelination in peripheral nervous system.
BACKGROUND : Haematological abnormalities are important to detect.
BACKGROUND : Hand-grip strength ( HGS ) serves as a proxy measure for muscle function and physical health.
BACKGROUND : Handgrip strength is a simple measurement of overall muscular strength and is used to detect sarcopenia.
BACKGROUND : Having a network of close relationships may reduce the risk of developing dementia.
Background : Having longer lived parents has been shown to be an important predictor of health trajectories and life span.
BACKGROUND : Heading impairs cognition in the short and medium-terms ; however , little is known about the long-term consequences.
BACKGROUND : Healthcare professionals have an important role to play both as advisers-influencing smoking cessation-and as role models.
BACKGROUND : Health care professionals need a simple and pragmatic clinical approach for the management of recurrent fallers in clinical routine.
BACKGROUND : Health disparities begin early in life and persist across the life course.
BACKGROUND : Health literacy skills tend to decline during ageing , which is often attributed to age-related cognitive decline.
BACKGROUND : Health-related quality of life ( HRQOL ) is increasingly measured as an outcome for clinical and health services research.
BACKGROUND : Health-related quality of life ( HRQOL ) levels and their determinants in those living in nursing homes are unclear.
BACKGROUND : Health risks associated with subclinical hypothyroidism in older adults are unclear.
BACKGROUND : Health service utilization rises with age , and yet , its determinants are poorly understood.
BACKGROUND : Healthy , active ageing is strongly associated with good mental wellbeing which in turn helps to prevent mental illness.
BACKGROUND : Healthy ageing is an increasingly important public health target globally.
BACKGROUND : Healthy aging includes physical , psychological , social , and spiritual well-being in later years.
BACKGROUND : Healthy but sedentary aging leads to cardiovascular stiffening , whereas life-long endurance training preserves left ventricular ( LV ) compliance.
BACKGROUND : Healthy dietary patterns may protect against age-related cognitive decline , but results of studies have been inconsistent.
BACKGROUND : Healthy older adults report greater well-being and life satisfaction than their younger counterparts.
BACKGROUND : Hearing loss is a common sensory impairment experienced by older persons.
BACKGROUND : Heart failure ( HF ) is one of the leading causes of morbidity and mortality in South Korea.
BACKGROUND : Heart failure ( HF ) is one of the most debilitating chronic illnesses.
BACKGROUND : Heart failure ( HF ) is the most common diagnosis in hospitalized patients older than @number@ years of age.
BACKGROUND : Heart failure ( HF ) with preserved ejection fraction ( HFpEF ) is increasing with aging of the population.
BACKGROUND : Heart failure is an important public health concern , particularly among persons > 65 years of age.
BACKGROUND : Heart failure is highly prevalent among older adults and is associated with high treatment costs.
BACKGROUND : Helicobacter pylori ( HP ) infection and chronic atrophic gastritis ( CAG ) have shown strong associations with the development of gastric cancer.
BACKGROUND : Helicobacter pylori ( H. pylori ) -related diseases are responsible for a tremendous amount of morbidity and mortality in Japan.
BACKGROUND : Hematopoiesis is a paradigm for developmental processes , hierarchically organized , with stem cells at its origin.
BACKGROUND : Hemorrhage is a major complication of thrombolytic treatment.
BACKGROUND : Hepatic steatosis may develop after pancreatic resection , but its clinicopathological features remain unclear.
BACKGROUND : Hepatitis C ( HCV ) infection is an increasingly common cause of hepatocellular carcinoma ( HCC ) in China.
BACKGROUND : Hepatitis C virus infection and interferon treatment are often associated with anxiety , depressive symptoms and poor health-related quality of life.
BACKGROUND : Hepatitis D virus ( HDV ) infection affects 15-20 million individuals worldwide and causes severely progressive hepatitis.
BACKGROUND : Hepatocellular carcinoma ( HCC ) , one of the most common cancers world-wide occurs twice as often in men compared to women.
BACKGROUND : Herb mixtures are used as alternatives to hormone therapy in China for the treatment of partial androgen deficiency in aging men.
BACKGROUND : Heritability of Alzheimer's disease ( AD ) is estimated at @percent@ and genetic contributors have been widely sought.
BACKGROUND : Herpes zoster ( HZ ) has a relevant impact on the population in terms of incidence and complications.
BACKGROUND : Herpes zoster ( HZ ) is a prevalent viral disease that inflicts substantial morbidity and associated healthcare and socioeconomic burdens.
BACKGROUND : ( HHH ) syndrome is a rare autosomal recessive disorder of the urea cycle.
BACKGROUND : Higher cardiorespiratory fitness ( CRF ) is cross-sectionally associated with more conserved brain volume in older age , but longitudinal studies are rare.
BACKGROUND : Higher circulating levels of sPLA2-IIA mass or sPLA2 enzyme activity have been associated with increased risk of cardiovascular events.
BACKGROUND : Higher levels of physical activity are associated with a lower risk of cardiovascular events.
BACKGROUND : Higher long-term cumulative lead exposure predicts faster cognitive decline in older men , but evidence of an association in women is lacking.
BACKGROUND : Higher physical activity ( PA ) levels are known to be associated with lower risk of death.
BACKGROUND : High levels of homocysteine have been associated with increased risk for dementia although results have been inconsistent.
BACKGROUND : High levels of prolonged grief symptoms ( PGS ) and posttraumatic stress symptoms ( PTS ) are relatively common following bereavement.
BACKGROUND : High levels of β-amyloid ( Aβ ) characterize Alzheimer disease.
BACKGROUND : high morale is defined as future-oriented optimism.
BACKGROUND : High-resolution manometry ( HRM ) is increasingly used in the evaluation of anorectal disorders.
BACKGROUND : High variation in telomere length between individuals is already present before birth and is as wide among newborns as in adults.
BACKGROUND : Hip fracture in older patients often lead to permanent disabilities and can result in mortality.
BACKGROUND : Hip fracture patients have , in several studies , been shown to have excessive mortality.
BACKGROUND : Hip fractures are associated with diminished quality of life and survival especially amongst the elderly.
BACKGROUND : Hip fractures in the elderly population are associated with high morbidity and mortality.
BACKGROUND : Hippocampal changes may be a useful biomarker for Alzheimer's disease if they are specific to dementia sub-type.
BACKGROUND : Histological evidence suggests that pathology in Parkinson's disease ( PD ) goes beyond nigrostriatal degeneration and also affects the cerebral cortex.
BACKGROUND : HIV and hepatitis C virus ( HCV ) infections may increase interleukin-6 ( IL-6 ) and C-reactive protein ( CRP ) .
BACKGROUND : HIV-infected individuals are at increased risk of tissue inflammation and accelerated vascular aging ( 'inflamm-aging' ) .
BACKGROUND : HIV-infected individuals may be at risk for the premature onset of age-associated noncommunicable comorbidities.
BACKGROUND : HIV infection has been associated with an increased risk of fragility fracture.
BACKGROUND : HIV infection is associated with increased risk of cardiovascular disease ( CVD ) in men.
BACKGROUND : HIV is associated with end-organ diseases of aging via unclear mechanisms.
BACKGROUND : HIV is increasingly considered a chronic illness.
BACKGROUND : Home healthcare services are important in aging societies worldwide.
BACKGROUND : Homeless patients face unique challenges in obtaining primary care responsive to their needs and context.
BACKGROUND : Hospice and palliative care organizations are expanding their use of standardized instruments and other approaches to measure quality.
BACKGROUND : Hospice care is most appropriate when a patient no longer benefits from curative treatment and has limited life expectancy.
BACKGROUND : Hospital admissions may provide an opportunity to discontinue potentially inappropriate medications ( PIMs ) in older patients.
BACKGROUND : hospitalised older people are at risk for poor functioning after hospital discharge.
BACKGROUND : Hospitalised older people are at risk of functional decline.
BACKGROUND : Hospital readmissions from skilled nursing facilities ( SNFs ) are common.
BACKGROUND : Hospitals are currently admitting an increasing number of older people , and more than one-third could have an underlying mental health problem.
BACKGROUND : How body composition , specifically skeletal muscle mass , compares in Mexican elderly to other ethnic groups has not previously been reported.
BACKGROUND : How drug adverse events ( AEs ) are communicated in the United States may mislead consumers and result in low adherence.
BACKGROUND : Human adipose tissue is an ideal autologous source of mesenchymal stem cells ( MSCs ) for various regenerative medicine and tissue engineering strategies.
BACKGROUND : Human aging is associated with DNA methylation changes at specific sites in the genome.
BACKGROUND : Human aging is associated with profound changes in one of the major epigenetic mechanisms , DNA methylation.
BACKGROUND : Human brain aging has received special attention in part because of the elevated risks of neurodegenerative disorders such as Alzheimer's disease in seniors.
BACKGROUND : Human colon adenocarcinoma cells are resistant to chemotherapeutic agents , such as anthracyclines , that induce death by increasing the reactive oxygen species.
BACKGROUND : Human hair cuticle is always exposed to various stresses and then gradually lost in daily life.
BACKGROUND : Human homeostasis is time related.
BACKGROUND : Human leukocyte telomere length ( LTL ) decreases with age and shorter LTL has previously been associated with increased prospective mortality.
BACKGROUND : Human lifespan is approximately @percent@ heritable , and genetic factors may be particularly important for achieving exceptional longevity.
BACKGROUND : Human papillomavirus ( HPV ) infection is the main etiological factor for the development of cervical cancer.
BACKGROUND : Human skin aging is a multifactorial and complex biological process affecting the different skin constituents.
BACKGROUND : Hyaluronic acid ( HA ) dermal fillers are effective and safe for correction of facial rhytides.
BACKGROUND : Hyaluronic acid ( HA ) fillers and poly-L-lactic acid ( PLA ) fillers are frequently used to correct facial wrinkles.
BACKGROUND : Hyaluronic acid ( HA ) fillers are frequently used for the correction of facial soft tissue defects.
BACKGROUND : Hyaluronic Acid ( HA ) fillers are widely used for restoring facial volume.
BACKGROUND : Hyaluronic acid ( HA ) fillers such as Restylane ( ® ) are frequently used for the correction of facial soft tissue defects.
BACKGROUND : Hyaluronic acid ( HA ) gels have been used as filler material in the aesthetic field.
BACKGROUND : Hyperglycaemia increases the risk of type @number@ diabetes , heart disease and stroke , and is influenced by weight.
BACKGROUND : Hyperpigmentation is a common concern and has many causes including lentigines and melasma.
BACKGROUND : Hypertension control in Hispanics / Latinos lag behind general US trends by 10-15%.
BACKGROUND : Hypertension increases with increasing age.
BACKGROUND : Hypertension in elderly patients is one of the main problems in cardiovascular diseases.
BACKGROUND : Hypertension is associated with myocardial fibrosis , an increase in ECV , and AF.
BACKGROUND : Hypertension is related with cognitive decline in the elderly.
BACKGROUND : Hypnosedatives are commonly prescribed for anxiety and sleep problems.
BACKGROUND : Hypogonadism , defined as a low serum testosterone in the presence of signs and symptoms , is common , particularly in aging men.
BACKGROUND : Hyponatremia is a common electrolyte disturbance in the hospitalized elderly sick patients.
BACKGROUND : Hypothermia is related to increased morbidity and mortality in very preterm infants ; continuous temperature monitoring is necessary.
BACKGROUND : ICD prolong life in selected patients , but ICD implantation carries the risk of periprocedural complications.
BACKGROUND : ICU admissions are ever increasing across the United States.
BACKGROUND : Identification of families at risk for ovarian cancer offers the opportunity to consider prophylactic surgery thus reducing ovarian cancer mortality.
Background : Identification of genes or fundamental biological pathways that regulate aging phenotypes and longevity could lead to possible interventions to increase healthy longevity.
BACKGROUND : Identification of gene variants that contribute to exceptional survival may provide critical biologic information that informs optimal health across the life span.
BACKGROUND : Identification of novel biomarkers is needed to improve the diagnosis and prognosis of heart failure ( HF ) .
BACKGROUND : Identifying factors associated with functional declines in older adults is important given the aging of the population.
BACKGROUND : Identifying factors associated with recommended physical activity ( PA ) levels are critical in efforts to combat the obesity epidemic and related comorbidities.
BACKGROUND : Identifying individuals at risk for developing Alzheimer disease ( AD ) is of utmost importance.
BACKGROUND : Identifying mild cognitive impairment ( MCI ) in midlife could improve early identification of Alzheimer's disease ( AD ) .
BACKGROUND : Identifying modifiable determinants of fat mass and muscle strength in older adults is important given their impact on physical functioning and health.
BACKGROUND : Identifying novel risk markers in cardiovascular patients remains a research priority.
BACKGROUND : Idiopathic epiretinal membrane ( iERM ) is a fibrocellular membrane that proliferates on the inner surface of the retina at the macular area.
BACKGROUND : Idiopathic membranous nephropathy ( IMN ) is increasingly seen in older patients.
BACKGROUND : IGF1 is responsible for regulation of growth , metabolism and differentiation of human cells.
BACKGROUND : Immigration to the Nordic countries has increased in the last decades and foreign-born inhabitants now constitute a considerable part of the region's population.
BACKGROUND : Immune function may influence the ability of older adults to maintain or improve muscle mass , strength , and function during aging.
BACKGROUND : Immune responses are generally impaired in aged mammals.
BACKGROUND : Immunity to the antigenically diverse parasite Plasmodium falciparum is acquired gradually after repeated exposure.
BACKGROUND : Immunofluorescence ( IF ) plays a major role in quantifying protein expression in situ and understanding cell function.
BACKGROUND : Impaired blood pressure regulation contributes to the development of diabetic complications.
Background : Impaired endogenous stem cell repair capacity is hypothesized to be a biologic basis of frailty.
BACKGROUND : Impaired functional and cognitive status is an important outcome for older adults undergoing major cardiac surgery.
BACKGROUND : Impaired liver function in men can result in erectile dysfunction or hypogonadism or both.
BACKGROUND : Impaired renal function has been linked to cognitive impairment.
BACKGROUND : Impairment of the autonomic nervous system activity may be involved in the development of hypertension.
BACKGROUND : Impairments in cognitive functions are common in patients suffering from psychiatric disorders , such as schizophrenia and bipolar disorder.
BACKGROUND : Important associations have been found between social relationships and various mental health outcomes.
BACKGROUND : Improving health care quality requires effective and timely spread of innovations that support evidence-based practices.
BACKGROUND : Improving quality of care for people with dementia is a high priority.
BACKGROUND : Improving the early detection of diabetic nephropathy remains a great challenge in disease management.
BACKGROUND : Inadequate oxygenation may cause lesions and brain atrophy during aging.
BACKGROUND : In adults , dosages of some anaesthetic agents are based on lean body mass ( LBM ) rather than body weight.
BACKGROUND : In aging populations , multimorbidity causes a disease burden of growing importance and cost.
BACKGROUND : In aging societies , zest for work may be pivotal when deciding to stay occupationally active longer.
BACKGROUND : In Alzheimer's disease ( AD ) and mild cognitive impairment ( MCI ) , apathy was associated with faster clinical deterioration.
BACKGROUND : In Alzheimer's disease ( AD ) , some patients present with cognitive impairment other than episodic memory disturbances.
BACKGROUND : In Alzheimer's disease synapse loss precedes neuronal loss and correlates best with impaired memory formation.
BACKGROUND : In an aging population an increasing number of breast cancers is diagnosed in elderly women.
BACKGROUND : In any aging society , the sociolegal construction of intergenerational relationships is of great importance.
BACKGROUND : Inappropriate medications are often used in older adults despite their unfavourable risk-to-benefit profile.
BACKGROUND : Inappropriate medication use is common in the elderly and the risks associated with their use are well known.
BACKGROUND : Inbreeding can be associated with a modification of disease risk due to excess homozygosity of recessive alleles affecting a wide range of phenotypes.
BACKGROUND : In changing higher education environments , medical educators are increasingly challenged to prepare new doctors to care for ageing populations.
BACKGROUND : In children , exhaled nitric oxide ( eNO ) is usually confounded by factors such as age and height.
BACKGROUND : Incidence of epilepsy in elderly patients is higher than in any other group.
BACKGROUND : Incisional hernia in aged patients represents a challenge even for experienced surgeons.
BACKGROUND : Incisional hernia is one of the most frequent complications after abdominal surgery , with incidences up to @percent@.
BACKGROUND : In clinical practice , laboratory results are often important for making diagnostic , therapeutic , and prognostic decisions.
BACKGROUND : IncobotulinumtoxinA improves the appearance of facial rhytides and the aging neck.
BACKGROUND : IncobotulinumtoxinA was approved in Argentina in @number@ for the treatment of moderate to severe glabellar lines.
BACKGROUND : In contrast to its prominent function in cognition , the involvement of the hippocampus in gait control is still a matter of debate.
BACKGROUND : In contrast with most developed countries , mortality from acute myocardial infarction ( AMI ) continues to rise in China.
BACKGROUND : Increased epicardial fat volume ( EFV ) has been shown to be associated with coronary atherosclerosis.
BACKGROUND : Increased mortality risk at low body mass index values is well established for older persons.
BACKGROUND : Increased oxycodone use has been associated with adverse drug events , non-medical use and overdose deaths.
BACKGROUND : Increased production of reactive oxygen species ( ROS ) in mitochondria has been proposed as the pathogenic mechanism for chronic complications of diabetes.
BACKGROUND : Increased stride time variability has been associated with memory impairment in mild cognitive impairment.
BACKGROUND : Increased use of drugs has raised concern about the risks of polypharmacy in elderly populations.
BACKGROUND : Increasing age has traditionally been associated with impairment in wound healing after operative interventions.
BACKGROUND : Increasing age is a significant risk factor for prostate cancer.
BACKGROUND : Increasing arterial stiffness is an important contributor to declining cardiovascular health in ageing.
BACKGROUND : Increasing evidence indicates that proteotoxicity plays a pathophysiologic role in experimental and human cardiomyopathy.
BACKGROUND : Increasing evidence links postoperative cognitive dysfunction ( POCD ) to surgery and anesthesia.
BACKGROUND : Increasing evidence shows that some cancers originate in utero.
Background : Increasing evidence suggests that postoperative delirium may result in long-term cognitive decline among older adults.
BACKGROUND : Increasing life expectancy necessitates the better understanding of the neurophysiological underpinnings of age-related cognitive changes.
BACKGROUND : Increasingly , patients are using health-related information available on the internet.
BACKGROUND : Increasingly , researchers have begun to explore pathways through which psychosocial factors might influence cardiovascular disease , with some emphasis on early markers.
BACKGROUND : Increasingly , researchers have begun to explore the association between depression and mortality.
BACKGROUND : Increasing numbers of older patients are developing established renal failure and considering kidney transplant as a renal replacement therapy ( RRT ) option.
BACKGROUND : Increasing participant satisfaction with health interventions can improve compliance with recommended health behaviors and lead to better health outcomes.
BACKGROUND : In demented older adults , in vivo amyloid imaging shows agreement with diagnostic neuropathologic assessment of β-amyloid ( Aβ ) .
BACKGROUND : India's elderly population is rising at an unprecedented rate , with a majority living in rural areas.
BACKGROUND : Indication bias is the major challenge in assessing treatment effectiveness in observational studies.
BACKGROUND : Individuals typically self-identify symptoms of facial aging that lead them to seek facial aesthetic treatments.
BACKGROUND : Individuals with HF have four times increased risk of cognitive impairment , yet cognitive intervention studies are sparse.
BACKGROUND : Individuals with mental illness are highly vulnerable to personal health and safety threats.
BACKGROUND : Individuals with schizophrenia have functionally significant deficits in automatic and controlled social cognition , but no currently available pharmacologic treatments reduce these deficits.
BACKGROUND : In eukaryotes the genetic material is enclosed by a continuous membrane system , the nuclear envelope ( NE ) .
BACKGROUND : Infantile neuroaxonal dystrophy ( INAD ) is a rare autosomal-recessive neurodegenerative disorder.
BACKGROUND : Infarcts in the brain can be divided into larger cortical and smaller deep lacunar infarcts.
BACKGROUND : Infection plays a role in the pathogenesis of many human malignancies.
BACKGROUND : Infections are frequent complications of hospitalization , particularly in the elderly.
BACKGROUND : Infections frequently occur in patients with dementia and antibiotics are often prescribed , but may also be withheld.
BACKGROUND : Infertility affects ∼7% of all men.
BACKGROUND : Inflammation is linked to cognitive decline in midlife , but the neural basis for this link is unclear.
BACKGROUND : Inflammatory processes play a pivotal role in the degenerative process of Alzheimer's disease.
BACKGROUND : Information on fillers and their behavior over time in the different layers of tissue is limited.
BACKGROUND : In Guadeloupe , Aedes aegypti mosquitoes are the only vectors of dengue and chikungunya viruses.
Background : in hospitalised older adults , cognitive impairments are common and may be associated with functional outcomes.
BACKGROUND : In hospitalized older patients , falls are likely to occur during night toileting needs.
BACKGROUND : In hospitals , length of stay ( LOS ) is a priority but it may be prolonged by malnutrition.
BACKGROUND : In human , a reduction in estrogen has been proposed as one of the key contributing factors for postmenopausal osteoporosis.
BACKGROUND : In increasingly aging populations , awareness of outcomes of older patients treated with biologics is becoming more important.
BACKGROUND : In Italy , the prevalence of elder abuse is estimated from @number@ to @number@ %.
BACKGROUND : Initiatives to accelerate the adoption and implementation of evidence-based practices benefit from an association with influential individuals and organizations.
BACKGROUND : Injectable daxibotulinumtoxinA ( RT002 ) is an investigational botulinum toxin Type A in clinical development.
BACKGROUND : Injectable forms of anesthesia for nonsurgical facial rejuvenation , although efficacious , are uncomfortable for the patient.
BACKGROUND : Injection of dermal fillers is one of the most commonly performed cosmetic procedures.
BACKGROUND : Injection-related pain of dermal fillers is a consistent and bothersome problem for patients undergoing soft tissue augmentation.
BACKGROUND : Injection therapies are often considered alongside exercise for chronic midportion Achilles tendinopathy ( AT ) , although evidence of their efficacy is sparse.
BACKGROUND : In light of the demographic aging trend in Europe , investigation into successful aging is a public health priority.
BACKGROUND : In low- and middle-income countries neonatal infections are important causes of infant mortality.
BACKGROUND : In mammals , the IGF-1 pathway affects the phenotype of aging.
BACKGROUND : In many countries , primary care physicians determine whether or not older drivers are fit to drive.
BACKGROUND : In many parts of the world the provision of psychogeriatric inpatient units ( PGUs ) remains limited.
BACKGROUND : In many western countries individuals will need to continue their professional careers beyond the current retirement age.
BACKGROUND : In most countries , red blood cells ( RBCs ) can be stored up to @number@ days before transfusion.
BACKGROUND : In negotiating stairs , low foot clearance increases the risk of tripping and a fall.
BACKGROUND : In nonsurgical facial rejuvenation , autologous fat and dermal fillers have become an effective method to achieve symmetry and balance of the midface.
BACKGROUND : In Norway , there is a focus on home-dwelling people with dementia receiving the opportunity to participate in organized meaningful activities.
BACKGROUND : In @number@ dual-eligible nursing home residents were randomly assigned to a Medicare Part D prescription drug plan ( PDP ) .
BACKGROUND : In @number@ the third-year community course at the University of Liverpool was reorganised to have an emphasis on disability.
BACKGROUND : In order to determine physical capability , objective methods for the assessment of performance are required.
Background : In populations pauci-immune to malaria , risk of severe malaria increases with age.
BACKGROUND : In premature ovarian failure ( POF ) , cessation of menstruation occurs before the expected age of menopause.
BACKGROUND : Instantaneous wave-free ratio ( iFR ) has been used in clinical practice to identify functionally significant stenosis and to guide treatment strategy.
BACKGROUND : Instrumental activities of daily living ( IADLs ) exhibit strong predictive power for the presence of dementia and mild cognitive impairment.
BACKGROUND : Insufficiency in vitamin D , a neurosteroid hormone , is associated with cognitive decline in older adults.
BACKGROUND : Insulin is an important osteotropic hormone but may be negatively associated with bone mass after adjustment for body mass index in adolescent populations.
BACKGROUND : Insulin pumps and real-time continuous glucose monitoring devices have recently been combined into the sensor-augmented pump ( SAP ) system.
BACKGROUND : Insulin resistance , i.e. impaired insulin sensitivity , and type @number@ diabetes are more prevalent in elderly humans.
BACKGROUND : Insulin resistance ( IR ) increases Alzheimer's disease ( AD ) risk.
BACKGROUND : Insulin resistance is linked to many human chronic diseases.
BACKGROUND : Intact foveal bulge has been associated with good visual outcome in retinal diseases.
BACKGROUND : In Taiwan , upper blepharoplasty has become one of the most commonly performed rejuvenation operations.
BACKGROUND : Interactions between antiretroviral ( ARV ) therapy and medications to treat age-related comorbidities are a growing concern in the aging HIV population.
BACKGROUND : Interest in 3D inertial motion tracking devices ( AHRS ) has been growing rapidly among the biomechanical community.
BACKGROUND : Interest in anti-aging approaches has grown significantly in recent years.
Background : Interplays between inflammation and mitochondrial biology are reported.
BACKGROUND : Interventionist cardiologists are often reluctant to undertake PCI in very elderly patients due to the perception of poor outcome in this high-risk cohort.
BACKGROUND : Interventions in primary health care settings have been effective in increasing physical fitness.
BACKGROUND : Interventions to promote physical activity ( PA ) among older adults can positively impact PA behaviour and other health outcomes.
BACKGROUND : Intervertebral disc ( IVD ) cells experience a broad range of physicochemical stimuli under physiologic conditions , including alterations in their osmotic environment.
BACKGROUND : Intestinal Behcet's disease ( BD ) is a specific subtype of BD.
BACKGROUND : In the aging population cardiovascular disease ( CVD ) is highly prevalent.
BACKGROUND : In the aging society , there is a growing number of patients with advanced degenerative disease of the spine.
BACKGROUND : In the antibiotic era , tuberculosis ( TB ) still causes a substantial number of mortalities.
BACKGROUND : In the context of population aging , multimorbidity has emerged as a growing concern in public health.
BACKGROUND : In the elderly , the ankle-brachial index ( ABI ) has greater than @percent@ sensitivity and specificity for peripheral artery disease identification.
BACKGROUND : In the epidemiology of late life depression , few insights are available on the co-occurrence of subthreshold depression and comorbid symptoms of anxiety.
BACKGROUND : In the last decades , many community-based studies have addressed predictors of nursing home placement ( NHP ) among the elderly.
BACKGROUND : In the last @number@ years , @number@ patients with type C distal humeral fractures ( AO13-C1-3 ) were treated at our hospital operatively.
BACKGROUND : In the modern society , aging had been a major problem.
BACKGROUND : In the past decades knowledge on adequate treatment of affective disorders and awareness of the negative consequences of long-term benzodiazepine use increased.
BACKGROUND : In the world ageing population era , aging diseases and aging disorders are crucial.
BACKGROUND : In this aging society , attention has not been fully given to brain arteriovenous malformations ( AVMs ) in elderly patients.
BACKGROUND : In this study , we examined epidemiological aspects of dynamic changes in incidences of laryngeal cancer in male and female populations in Kazakhstan.
BACKGROUND : In this study we investigated the role of hippocampal volume ( HV ) in visual memory.
BACKGROUND : Intramuscular adipose tissue ( IMAT ) of the lower extremity is a strong negative predictor of mobility function.
BACKGROUND : Intravenous bridging strategies increase exposure of antifungal prophylaxis in high-risk hematological patients.
BACKGROUND : Intrinsic and extrinsic factors , including ultraviolet irradiation , lead to visible signs of skin aging.
BACKGROUND : In view of age-related brain changes , identifying factors that are associated with healthy aging are of great interest.
BACKGROUND : In vitro evidence suggests anti-estrogenic properties for retinol and carotenoids , supporting a chemo-preventive role of these phytochemicals in estrogen-dependent cancers.
BACKGROUND : Iodine deficiency is one of the three key micronutrient deficiencies highlighted as major public health issues by the World Health Organisation.
BACKGROUND : Ionizing radiation has been demonstrated to result in degranulation of dermal mast cells.
BACKGROUND : IPL is frequently used to improve telangiectasias , lentigos , and skin texture.
BACKGROUND : Iran is presently designing a long-term plan for promoting science , technology and innovation in medicine.
BACKGROUND : Iron deficiency and iron-deficiency anemia are the most common nutritional deficiencies in children , especially in developing countries.
BACKGROUND : Iron deficiency anemia ( IDA ) is a frequently encountered condition in clinical practice.
BACKGROUND : Irritable bowel syndrome ( IBS ) is common with prevalence reported between @number@ and @number@ %.
BACKGROUND : Ischemic arterial strokes of the ophthalmic artery and its branches and posterior cerebral artery are common causes of visual disability.
BACKGROUND : Italy is expected to experience the largest growth in persons ≥65 years ( > 20% by @number@ ) .
BACKGROUND : Italy is particularly concerned by population ageing.
BACKGROUND : It has been suggested that oxidative injuries have a role in the pathogenesis of Alzheimer's disease ( AD ) .
BACKGROUND : It has been suggested that the plasticizer di ( 2-ethylhexyl ) phthalate ( DEHP ) exerts obesogenic effects after pre- or perinatal exposure.
BACKGROUND : It has been theorized that neural recovery is related to temporal coding of speech sounds.
BACKGROUND : It is a well-described clinical phenomenon that females live longer than males , yet tend to experience greater levels of co-morbidity and disability.
BACKGROUND : It is commonly requested that perioral and lateral canthal rhytides , which result from extrinsic and intrinsic factors , be rejuvenated.
BACKGROUND : It is evidently shown that colour has physical , psychological and sociological effects on human beings.
BACKGROUND : It is generally acknowledged that back pain ( BP ) is a common condition already in childhood.
BACKGROUND : It is important to have a replicable easy method for monitoring atrophy progression in Alzheimer's disease.
BACKGROUND : It is important to understand the coping strategies that optimize or restrict participation or quality of life , especially for older adults.
BACKGROUND : It is known that long-term psychosocial stress may cause or contribute to different diseases and symptoms and accelerate aging.
BACKGROUND : It is not clear whether recent increases in life expectancy are accompanied by a concurrent postponement of activity limitations.
BACKGROUND : It is not known whether salt intake decreases over time in the same population.
BACKGROUND : It is often difficult to determine the correct size of endotracheal tubes ( ETT ) needed for intubating pediatric patients.
BACKGROUND : it is uncertain as to which measures of gait best predict those who are likely to fall.
BACKGROUND : It is unclear whether in late life serum thyroid-stimulating hormone ( TSH ) predicts risk of developing cognitive impairment.
BACKGROUND : It is unknown whether dietary recommendations for cancer prevention are applicable to the elderly.
BACKGROUND : It is unknown whether the cerebellum affects cognitive function in an aging community-dwelling population.
BACKGROUND : It is unknown which commonly used Alzheimer disease ( AD ) biomarker values-baseline or progression-best predict longitudinal cognitive decline.
BACKGROUND : It is well known that loss of muscle mass ( quantitative change ) is a major change that occurs with aging.
BACKGROUND : It is widely assumed that poor health lowers life satisfaction when ageing.
BACKGROUND : It is widely believed that females have longer telomeres than males , although results from studies have been contradictory.
BACKGROUND : It seems that gene-environment interaction play most important role in Multiple Sclerosis development.
BACKGROUND : IVF treatments carry a high risk of twin pregnancy which confers a higher risk to the mother and child than singletons.
BACKGROUND : JAK2V617F mutation occurs in @percent@ of polycythemia vera ( PV ) and in @percent@ of essential thrombocythemia ( ET ) patients.
BACKGROUND : Japan has the fastest aging society in the world.
BACKGROUND : Japan has the highest aging population in the world and promotion of home health services is an urgent policy issue.
BACKGROUND : Japan has the highest rate of aging.
BACKGROUND : Jasmonates are plant hormones that exhibit anti-cancer and anti-inflammatory properties and have therefore raised interest for human health applications.
BACKGROUND : Juvéderm™ VOLUMA™ ( Voluma ) is a new injectable , long-lasting , resorbable hyaluronic acid filler.
BACKGROUND : Keeping older adults healthy and active is an emerging challenge of an aging society.
BACKGROUND : KL-6 is a high-molecular-weight glycoprotein classified as a human MUC1 mucin.
BACKGROUND : Klotho , an anti-aging gene , is a functional candidate for metabolic syndrome.
Background : Klotho gene was identified as an aging suppressor.
BACKGROUND : Knee osteoarthritis is a major cause of disability in the aging population.
BACKGROUND : Knee osteoarthritis ( kOA ) risk is increased by obesity and physical activities ( PA ) which mechanically stress the joint.
BACKGROUND : Knee osteoarthritis ( OA ) is largely attributable to chronic excessive and aberrant joint loading.
BACKGROUND : Knowledge about HIV infection in older persons is becoming increasingly important.
BACKGROUND : Knowledge of individual-level trajectories of Health Services Consumption ( HSC ) at End-of-Life ( EoL ) is scarce.
BACKGROUND : Knowledge on factors affecting the rate of cognitive decline and how to maintain cognitive functioning in old age becomes increasingly relevant.
Background knowledge on the concept of ageing , as this is defined scientifically for biological systems , is subsequently presented.
BACKGROUND : Laryngeal electromyography ( LEMG ) is accepted as safe , with minimal side effects.
BACKGROUND : Laser lipolysis is a less invasive approach to neck rejuvenation than open surgery or liposuction.
BACKGROUND : Late-life depression and physical frailty are supposed to be reciprocally associated , however , longitudinal studies are lacking.
BACKGROUND : Late-life depression is thought to differ in clinical presentation from early-life depression.
BACKGROUND : Late-life depression may be undiagnosed due to symptom expression.
BACKGROUND : Lateral canthal rhytides partly result from repetitive muscular actions of the orbicularis oculi.
BACKGROUND : Latin America has experienced increases in obesity.
BACKGROUND : Latinas with breast cancer suffer symptom and psychosocial health disparities.
BACKGROUND : LA volume increase is a sensitive independent marker for cardiovascular disease and adverse outcomes.
BACKGROUND : Laxity and rhytides are manifestations of photodamage on the chest.
BACKGROUND : Leading theories about the pathogenesis of fibromyalgia focus on central nervous dysregulation or sensitization , which can cause altered perception.
BACKGROUND : Left ventricular ( LV ) contraction displaces the aortic annulus and produces a force that stretches the ascending aorta.
BACKGROUND : Leptin and adiponectin communicate with organ systems in order to regulate energetic and metabolic homeostasis.
BACKGROUND : Leptin is one of the major adipokines in obesity that indicates the severity of fat accumulation.
BACKGROUND : Less downtime following esthetic interventions leads to the popularity of injectable solutions for facial rejuvenation treatments.
BACKGROUND : Leucocyte telomere length ( LTL ) is a complex trait associated with ageing and longevity.
BACKGROUND : Leukocyte cell-derived chemotaxin @number@ ( LECT2 ) is a hepatokine linking obesity to skeletal muscle insulin resistance.
BACKGROUND : Leukocyte telomere length ( LTL ) is an emerging marker of biological age.
BACKGROUND : Leukocyte telomere length ( LTL ) is considered a biomarker of human aging and based on cross-sectional studies it shortens with age.
BACKGROUND : Leukocyte telomere length ( LTL ) is related to diseases of aging , but studies of mortality have been inconsistent.
BACKGROUND : Leukocyte telomere length ( LTL ) ostensibly shortens with age and has been moderately associated with mortality.
BACKGROUND : leukocyte telomere length ( TL ) is considered a marker of biological aging.
BACKGROUND : Life expectancy , as well as the average age of patients undergoing solid organ transplantation , increases constantly.
BACKGROUND : Lifestyle changes around the time of menopause have the potential to impact on morbidity and eventual mortality.
BACKGROUND : Lifestyle factors associated with hypertension ( HT ) in South Asian populations are relatively unknown.
BACKGROUND : Lifestyle factors represent prime targets for behaviour change interventions to promote healthy ageing and reduce dementia risk.
BACKGROUND : Lifestyle has been proven to have a dramatic effect on the risk of age-related diseases.
BACKGROUND : Lifestyles such as unhealthy diets and the lack of physical activity have been contributed to the increased prevalence of obesity.
BACKGROUND : Lifetime risk estimation is used to predict long-term cardiovascular disease ( CVD ) risk across the entire life span.
BACKGROUND : Light at visible spectrum has been associated with anti-inflammatory and anti-aging effects.
BACKGROUND : light-to-moderate drinking is apparently associated with a decreased risk of physical limitations in middle-aged and older adults.
BACKGROUND : Limb injuries comprise 50-60% of U.S. Service member's casualties of wars in Afghanistan and Iraq.
BACKGROUND : Limitations in mobility are common among older adults with cardiovascular and cardiometabolic disorders and have profound effects on health and well-being.
BACKGROUND : Limited evidence exists on the effectiveness of the chronic care model for people with multimorbidity.
BACKGROUND : Limited evidence exists on the utilization of surveillance colonoscopy in colorectal cancer ( CRC ) screening programs.
BACKGROUND : Limited evidence exists to inform physical activity ( PA ) and sedentary behavior guidelines for older people , especially women.
BACKGROUND : Limited health care budgets and population aging result in a need to compare care services on their benefits and costs.
BACKGROUND : Limited health literacy is associated with worse physical function in cross-sectional studies.
Background : Limited research is available on the relationship between social support , social strain , and cognitive function among community-dwelling U.S. Chinese older adults.
BACKGROUND : Lipid accumulation product ( LAP ) is a recently proposed good discriminator for cardiovascular disease and diabetes.
BACKGROUND : Lipids and lipoproteins are recognized as the most important modifiable risk factors for cardiovascular disease.
BACKGROUND : Lipofuscin is the most consistent and phylogenically constant morphologic marker of cellular aging.
BACKGROUND : Lipofuscin-like pigments ( LFLP ) are considered a hallmark of aging.
BACKGROUND : Lipoprotein ( a ) ( Lp ( a ) ) is an independent risk factor for cardiovascular disease.
BACKGROUND : Lipoprotein-X ( Lp-X ) is an abnormal phospholipid-rich lipoprotein found in patients with cholestatic liver disease.
BACKGROUND : Literature reports on the effects of resistance training on heat shock protein70 ( Hsp70 ) adaptation in older subjects are scarce.
BACKGROUND : Little evidence is available on the effects of incident diabetes or diabetes duration on cognitive aging.
BACKGROUND : Little information is available on the effect of dementia on outcomes of elderly patients with hemorrhagic peptic ulcer disease at the population level.
BACKGROUND : little is known about changes in the quality of medical care for older adults over time.
BACKGROUND : Little is known about coronary plaque in human immunodeficiency virus ( HIV ) -infected women.
BACKGROUND : Little is known about factors affecting adherence to highly-structured and supervised exercise programs in older people.
BACKGROUND : Little is known about factors that modify the effectiveness of exercise interventions in increasing exercise.
BACKGROUND : Little is known about how the proportions of dependency states have changed between generational cohorts of older people.
BACKGROUND : Little is known about how the relationship between chronic disease , impairment , and disability has changed over time among older adults.
BACKGROUND : Little is known about mortality among nonagenarians after an earthquake.
BACKGROUND : Little is known about quality of life and work productivity in autoimmune bullous dermatoses ( AIBDs ) .
BACKGROUND : Little is known about recovery of female sexual function following an acute myocardial infarction ( MI ) .
BACKGROUND : Little is known about the effects of age on the symptoms of anxiety disorder.
BACKGROUND : Little is known about the impact of pain on physical functioning among the oldest-old subjects.
BACKGROUND : Little is known about the prevalence and relevant factors of polypharmacy in nonagenarian and centenarians.
BACKGROUND : Little is known about the prevalence , predictors and gender differences in hand grip strength of older adults in Africa.
BACKGROUND : Little is known about the safety and efficacy of endovascular therapy for acute ischemic stroke in octogenarians.
BACKGROUND : Little is known about the sex-specific differences in left ventricular ( LV ) diastolic dysfunction ( DD ) predictors.
BACKGROUND : Little is known about α-tocopherol's bioavailability as a constituent of food or its dependence on a subject's age.
BACKGROUND : Liver fibrosis was viewed as a reversible process.
BACKGROUND : Locomotive disorders are one of the main causative pathologies for the condition requiring assistance on activities of daily living ( ADL ) .
BACKGROUND : Loneliness among community-dwelling older people is a common problem , with serious health consequences.
BACKGROUND : Loneliness and depression are very common in the aged population.
BACKGROUND : Loneliness is a significant concern among the elderly , particularly in societies with rapid growth in aging populations.
BACKGROUND : Longer life expectancy is associated with an increasing prevalence of kidney disease.
BACKGROUND : Longevity-associated genes may modulate risk for age-related diseases and survival.
BACKGROUND : Longitudinal associations between depressive symptoms and blood pressure have been inconsistent.
BACKGROUND : Long-term care administrators ( administrators ) can influence the care nursing home residents receive.
BACKGROUND : Long-term longitudinal studies of lung function from childhood to adulthood are important in linking our understanding of childhood risk factors to adult disease.
BACKGROUND : Long working hours are associated with increased risk for coronary heart disease ( CHD ) .
BACKGROUND : Loss of balance confidence is a frequent condition that affects 20-75% of community-dwelling older persons.
BACKGROUND : Loss of mechanical tension appears to be the major factor underlying decreased collagen synthesis in aged skin.
BACKGROUND : Loss of muscle mass occurs with aging and in lower limbs it may be accelerated by foot problems.
BACKGROUND : Loss of muscle mass with aging is a major public health concern.
BACKGROUND : Loss of physical functioning is an early marker of declining health in older people.
Background : Low blood serum or plasma concentrations of the xanthophyll carotenoids lutein and zeaxanthin have been implicated in poorer cognitive health in older adults.
Background : Low-dose computed tomography lung cancer ( LDCT ) screening is an effective way to decrease lung cancer mortality.
BACKGROUND : Lower extremity physical performance measured at one point in time is a powerful predictor of future disability.
BACKGROUND : Lower eyelid retraction can be the unfortunate result of aesthetic surgery , trauma , disease , or the aging processes.
BACKGROUND : Lower gastrointestinal endoscopy can decrease colorectal cancer risk strongly through detection and removal of adenomas.
BACKGROUND : Lower levels of health literacy have been associated with adverse health outcomes , especially for older adults.
BACKGROUND : Lower urinary tract symptoms ( LUTS ) comprise a highly prevalent chronic condition among the aging male population.
BACKGROUND : Lower vitamin D status during gestation may be associated with cardiovascular disease risk later in life.
BACKGROUND : Low health literacy is common among aging patients and is a risk factor for morbidity and mortality.
BACKGROUND : Low levels of total 25-hydroxyvitamin D are common among black Americans.
BACKGROUND : Low literacy is common among the elderly and possibly more reflective of educational attainment than years of school completed.
BACKGROUND : Low-molecular-weight heparin is the standard treatment for cancer-associated venous thromboembolism.
BACKGROUND : low muscle strength is central to geriatric syndromes including sarcopenia and frailty.
BACKGROUND : Low muscle strength is related to an increased risk for several chronic diseases.
BACKGROUND : Low physical activity is a major risk factor for several age-related diseases.
BACKGROUND : Low socioeconomic status and high levels of body mass are two risk factors for elevated C-reactive protein , a biomeasure signifying inflammation.
Background : Low-trauma fractures of elderly women are a major public health concern.
BACKGROUND : Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases.
BACKGROUND : Lung cancer has a commonly understood behavioral etiology.
BACKGROUND : Lung function successfully predicts subsequent health.
BACKGROUND : Lymphangiectases are a histologic sign of lymphostasis , which is associated with decreased immune cell trafficking and cell-mediated immunity.
BACKGROUND : Macular pigment ( MP ) might provide some protection against age-related eye disease , and it is now being measured in ophthalmic practice.
BACKGROUND : Madagascar has some of the highest rates of child stunting , maternal malnutrition , and infant mortality in sub-Saharan Africa.
BACKGROUND : Magnesium deficiency is associated with poor physical performance , but no trials are available on how magnesium supplementation affects elderly people's physical performance.
BACKGROUND : Magnetic resonance imaging ( MRI ) studies show reduced cortical thickness in patients with schizophrenia and bipolar disorder.
BACKGROUND : Maintaining health and well-being in aging populations is critical.
BACKGROUND : Maintenance of lean muscle mass and related strength is associated with lower risk for numerous chronic diseases of aging in women.
BACKGROUND : Major adverse cardiac events ( MACEs ) are important causes of perioperative morbidity and mortality for elderly patients undergoing non-cardiac surgery.
BACKGROUND : Males are increasingly seeking minimally invasive cosmetic procedures such as botulinum toxin injection.
BACKGROUND : Malnutrition and frailty are two geriatric syndromes that significantly affect independent living and health in community-dwelling older adults.
BACKGROUND : Malnutrition is a common problem among older people and associated with reduced functional and cognitive ability.
BACKGROUND : Malnutrition is a common problem in older patients.
BACKGROUND : Malnutrition is common in hospital inpatients and is associated with increased morbidity and mortality.
BACKGROUND : Malnutrition is common in older adults and is associated with high costs and adverse outcomes.
BACKGROUND : Malnutrition is highly prevalent in the elderly.
BACKGROUND : Malnutrition is one of the key issues affecting the health of older people ( > 65years ) .
BACKGROUND : Mammographic breast arterial calcifications ( BACs ) are regarded as aging-related benign changes in breast cancer screening practices.
BACKGROUND : Mammographic density ( MD ) is one of the strongest breast cancer risk factors.
BACKGROUND : Many adiposity traits have been related to health complications and premature death.
BACKGROUND : many chronic conditions have their roots in modifiable health-related behaviours.
BACKGROUND : Many clinicians prescribe cautiously to older adults with common geriatric conditions for fear of causing adverse drug reactions ( ADRs ) .
BACKGROUND : Many countries are facing the burden of accelerated population aging and a lack of institutional support to meet the needs of older individuals.
BACKGROUND : Many functional , structural and evolutionary features of human genes have been observed to correlate with expression breadth and / or gene age.
BACKGROUND : Many inducible transcription factors are regulated through batteries of posttranslational modifications that couple their activity to inducing stimuli.
BACKGROUND : Many infants born prematurely experience growth failure following delivery , with subsequent catch-up growth.
BACKGROUND : Many kidney-tonifying Chinese herbal medicines exert effects on anti-aging by comprehensive interactions of multiple targets.
BACKGROUND : Many members of the American College of Emergency Physicians are now over the age of @number@
BACKGROUND : Many office-based assessment tools are used by occupational therapists to predict fitness to drive.
BACKGROUND : Many older individuals suffer from difficulty initiating and maintaining sleep , and consequently use hypnosedative medication.
BACKGROUND : Many older people worry about cognitive decline.
BACKGROUND : Many patients are admitted to hospital and are already malnourished.
BACKGROUND : Many patients with dementia live in the community and depend on a family member for assistance.
BACKGROUND : Many potentially inappropriate drugs prescribed to older people have anticholinergic properties as adverse effects and are therefore potentially harmful.
BACKGROUND : Many researchers have been concerned about the association of hair graying with systemic diseases.
BACKGROUND : Many smartphone applications ( apps ) for weight loss are available , but little is known about their effectiveness.
BACKGROUND : Many strategies have been evaluated to improve the prevention and control of cardiovascular ( CVD ) risk factors.
BACKGROUND : Many studies have been conducted to quantitatively estimate biological age using measurable biomarkers.
BACKGROUND : Many studies have explored the associations between microRNAs ( miRNAs ) polymorphisms and lung cancer susceptibility.
BACKGROUND : Many studies have shown that short telomere length ( TL ) is associated with high oxidative stress and various age-related diseases.
BACKGROUND : Many techniques have been presented over recent decades to address the neck contour in facial rejuvenation surgery.
BACKGROUND : Many young women experiment with using indoor tanning beds with some becoming regular users.
BACKGROUND : Marinobufagenin ( MBG ) , a bufadienolide cardiotonic steroid , induces cardiovascular fibrosis.
BACKGROUND : Markers for longevity that reflect the health condition and predict healthy aging are extremely scarce.
BACKGROUND : Mass spectrometric-based measurements of the steroid metabolome have been introduced to diagnose disorders featuring abnormal steroidogenesis.
BACKGROUND : Mastocytosisis a rare disease associated with chronic symptoms related to mast cell mediator release.
BACKGROUND : Meaningful occupational engagement is essential for successful aging.
BACKGROUND : Measurement of intestinal permeability is important in several diseases but currently several methods are employed.
BACKGROUND : Mechanical overload and poor quality of contractile elements related to metabolic abnormalities concur to motor disability of obesity.
BACKGROUND : Mechanical properties of human digits may have significant implications for the hand function.
BACKGROUND : Medical progress and the lifestyle modification have prolonged life expectancy , despite the development of chronic diseases.
BACKGROUND : Medication adherence is a multifaceted issue that is influenced by various factors.
BACKGROUND : Medication errors are the cause of common and dangerous adverse effects on patients.
BACKGROUND : Medication non-adherence is a major problem for elderly people.
BACKGROUND : Medication-related problems are common in the growing population of older adults and inappropriate prescribing is a preventable risk factor.
BACKGROUND : Medications with anticholinergic properties are frequently used in the elderly population.
BACKGROUND : Melatonin decreases night-time blood pressure ( BP ) by increasing nitric oxide ( NO ) in endothelial cells.
BACKGROUND : Memantine is an approved symptomatic treatment for moderate to severe Alzheimer's disease that reduces the excitotoxic effects of hyperactive glutamatergic transmission.
BACKGROUND : Memory complaints in older adults may be a precursor of measurable cognitive decline.
BACKGROUND : Memory decline is a prevalent aspect of aging but may also be the first sign of cognitive pathology.
BACKGROUND : Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes.
BACKGROUND : Men are a growing patient population in aesthetic medicine and are increasingly seeking minimally invasive cosmetic procedures.
BACKGROUND : Men are increasingly seeking aesthetic treatment with neuromodulators.
BACKGROUND : Men of color include a diverse population encompassing individuals with Fitzpatrick skin Types IV through VI.
BACKGROUND : Menopause is a natural phase in a woman's aging process , characterized by the cessation of menstruation.
BACKGROUND : Menopause is associated with sharp declines in concentrations of circulating estrogens.
BACKGROUND : Menopause is the onset of aging in women.
BACKGROUND : Menopause is the stage when the menstrual period permanently stops , and is a part of every woman's life.
BACKGROUND : Mental disorders influence people with a high prevalence and exert remarkable burden on community members.
BACKGROUND : Mental health professionals are frequently involved in mental capacity determinations.
BACKGROUND : Meropenem is used for the treatment of severe lower respiratory tract infections ( LRTIs ) caused by multidrug-resistant Gram-negative bacilli.
BACKGROUND : Mesenchymal stem cells derived from adipose tissue ( ADSC ) are multipotent stem cells , originated from the vascular-stromal compartment of fat tissue.
BACKGROUND : Mesenchymal stem cells ( MSCs ) have been considered as ideal cells for the treatment of a variety of diseases.
BACKGROUND : Metabolic profiles have been shown to provide prognostic information in patients with heart failure ( HF ) .
BACKGROUND : Metabolic profiling may provide insight into biologic mechanisms related to the maintenance of muscle and fat-free mass in functionally limited older adults.
BACKGROUND : Metabolic syndrome has become a major public health challenge worldwide.
BACKGROUND : Metabolic syndrome is a cluster of cardiovascular risk factors that greatly increase the risk of developing cardiovascular disease and type @number@ diabetes.
BACKGROUND : Metabolic syndrome ( MetS ) is associated with an increased risk of coronary heart diseases and stroke.
BACKGROUND : Metabolic syndrome ( MetS ) was common in the elderly , but its prognostic significance in older old population remained unclear.
BACKGROUND : Metallothioneins ( MT ) are important antioxidants involved in the ageing process of many tissues and organs.
BACKGROUND : Metformin is a worldwide accepted biguanide antidiabetic agent , and its effectiveness and benefit have already been well established.
BACKGROUND : Methamphetamine ( Meth ) abuse continues to be a major illicit drug of abuse.
BACKGROUND : Methicillin-resistant Staphylococcus aureus ( MRSA ) infections are associated with significant mortality and health care costs.
BACKGROUND : Mice models suggest epigenetic inheritance induced by parental allergic disease activity.
BACKGROUND : Microglia are considered the resident immune cells of the central nervous system ( CNS ) .
BACKGROUND : Microglia are involved in immune surveillance in intact brains and become activated in response to inflammation and neurodegeneration.
BACKGROUND : Microglia in the brain are the counterpart of macrophages and it functions as a first defense in the brain.
BACKGROUND : Micronutrients are associated with dementia and cognitive decline among older adults.
BACKGROUND : Microparticles ( MP ) are shed membrane vesicles released from activation or apoptosis of several cell types and carry a procoagulant activity.
BACKGROUND : Microparticles ( MPs ) have emerged as a surrogate marker of endothelial dysfunction and cardiovascular risk.
BACKGROUND : MicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases ( CVDs ) .
BACKGROUND : MicroRNAs ( miRNAs ) are endogenous small RNAs that are 21-25 nucleotides in length.
BACKGROUND : Microthrombosis and reactive inflammation contribute to neuronal injury after subarachnoid hemorrhage ( SAH ) .
BACKGROUND : Mid-dermal injection of stabilized hyaluronic acid ( HA ) is well established as a treatment to reduce the effects of skin aging.
BACKGROUND : Middle-aged and older American men and women have almost twice the rate of diabetes of men and women in England.
BACKGROUND : Midlife alcohol consumption ( beer , wine , and spirits ) was examined in relation to dementia incidence over @number@ years.
BACKGROUND : Midlife vascular disease risk is a strong risk factor for late-life dementia.
BACKGROUND : Migraine is one of the most common chronic neurological disorders.
BACKGROUND : Mild cognitive impairment encompasses the clinical continuum between physiologic age-related cognitive changes and dementia.
BACKGROUND : Mild cognitive impairment ( MCI ) and sleep disturbances are common features in Parkinson disease ( PD ) .
BACKGROUND : Mild cognitive impairment ( MCI ) has been defined as a transitional state between normal aging and dementia.
BACKGROUND : Mild cognitive impairment ( MCI ) has been suggested as a term for a boundary area between normal aging and dementia.
BACKGROUND : Mild cognitive impairment ( MCI ) increases dementia risk with no pharmacologic treatment available.
BACKGROUND : Mild cognitive impairment ( MCI ) is an intermediate state between normal aging and early dementia.
BACKGROUND : Mild cognitive impairment ( MCI ) is commonly associated with memory impairment.
BACKGROUND : Mild cognitive impairment ( MCI ) is considered a clinical stage between normal cognitive aging and dementia.
BACKGROUND : Mild hyperphosphatemia is a putative risk factor for cardiovascular disease [ CVD ] , loss of kidney function , and mortality.
BACKGROUND : Mindfulness-based stress reduction ( MBSR ) programs are becoming increasingly common , but have not been studied in low income minority older populations.
BACKGROUND : Minimizing the impact of oxidation on polyethylene components is important for preserving their mechanical integrity while in vivo.
BACKGROUND : Missing data are inevitable in almost all medical studies.
BACKGROUND : Missing values are commonly encountered on the Mini Mental State Examination ( MMSE ) , particularly when administered to frail older people.
BACKGROUND : Mitochondria are the major source of oxidative stress.
BACKGROUND : Mitochondrial DNA ( mtDNA ) has been proposed to be involved in carcinogenesis and aging.
BACKGROUND : Mitochondrial dysfunction is a prominent hallmark of many sensory neuropathies.
BACKGROUND : Mixed findings in biobehavioral research on heart disease may partly be attributed to age-related differences in the prognostic value of psychological distress.
BACKGROUND : Mobility and executive functions ( EFs ) decline with age , although associations between mobility and EFs are less clear.
BACKGROUND : Mobility is a main issue for health-related quality of life in old age.
BACKGROUND : Mobility is an essential aspect of everyday life and enables autonomy and participation.
BACKGROUND : Mobility limitation is highly prevalent among older adults and is central to the loss of functional independence.
BACKGROUND : Moderate calorie-restricted diets and exercise training prevent loss of lean mass and cardiovascular risk.
BACKGROUND : Modifiable vascular and lifestyle-related risk factors have been associated with dementia risk in observational studies.
BACKGROUND : Mono- and polysensitization are different IgE-mediated allergic phenotypes in children.
BACKGROUND : Monocytes and macrophages produce interleukin ( IL ) -10 , an immunoregulatory cytokine and a potent therapeutic tool for immune disorders.
BACKGROUND : More aging adults and the social acceptance of aesthetic treatments have increased the demand for minimally invasive aesthetic treatments.
BACKGROUND : More and more we are seeing depilatory mechanisms based on IPL technology and used at home.
BACKGROUND : More attention and understanding of the health and participation problems of adults with early and later onset disabilities in the Netherlands is needed.
BACKGROUND : Morphometric measurements of systemic atherosclerosis and direct quantification of visceral fat are only possible using materials from autopsy studies.
BACKGROUND : Mortality in children with severe acute malnutrition ( SAM ) remains high despite standardized rehabilitation protocols.
BACKGROUND : Most adults with chronic conditions live at home and rely on informal caregivers to provide support.
BACKGROUND : Most childhood cancer survivors will develop ionizing radiation treatment-related health conditions that , in many instances , resemble age-associated pathologies.
BACKGROUND : Most colorectal cancers develop from adenomas.
BACKGROUND : Most developed countries have considered population ageing as one of the economic challenges that need to be overcome.
BACKGROUND : Most elderly people attach great value to staying functionally independent for as long as possible.
BACKGROUND : Most laboratory-based studies on prospective memory show a decline with increasing age.
BACKGROUND : Most neuropsychological batteries , especially those most often used , are unsuitable for the assessment of patients with severe dementia.
BACKGROUND : Most of our social interactions involve perception of emotional information from the faces of other people.
BACKGROUND : Most of the alkaline phosphatase ( ALP ) isoenzymes are derived from the bones and liver.
BACKGROUND : Most of the literature on pathology of essential tremor ( ET ) has reported no consistent abnormalities.
BACKGROUND : Most senior veterans who live in veterans ' homes in Taiwan are single and have few intimate , interpersonal relationships.
BACKGROUND : Motor practice is an important component of neurorehabilitation.
BACKGROUND : Much attention has been focused on the need to design strategies to increase functional capacities in older populations.
BACKGROUND : Mucormycosis has emerged as a rare but frequently fatal invasive fungal disease.
BACKGROUND : multi-compartment medication devices ( MMDs ) are widely used , primarily by older people , to aid correct-medication taking.
BACKGROUND : Multimorbidity has been suggested to be associated with a variety of negative health-related outcomes.
BACKGROUND : Multimorbidity is a huge burden to individuals and societies and more attention should be paid on its risk factors and prevention possibilities.
BACKGROUND : Multiphoton tomography ( MPT ) is a novel non-invasive imaging method in dermatology allowing the depiction of the epidermis with sub-cellular resolution.
BACKGROUND : Multiple approaches to achieve eyelid tightening have been introduced over the years.
BACKGROUND : Multiple chronic conditions and low skeletal muscle mass are common features of aging that are detrimental to physical performance.
BACKGROUND : Multiple factors , including interactions between genetic and environmental risks , are important in susceptibility to rheumatoid arthritis ( RA ) .
BACKGROUND : Multiple methods are employed for modeling adaptation when projecting the impact of climate change on heat-related mortality.
BACKGROUND : Multiple nonablative skin rejuvenation techniques have been used to improve facial aging.
BACKGROUND : Multiple sclerosis has been associated with progressive brain volume loss.
BACKGROUND : Multiple therapies involving ablative and nonablative techniques have been developed for rejuvenation of photodamaged skin.
BACKGROUND : Muscle ageing contributes to both loss of functional autonomy and increased morbidity.
BACKGROUND : Muscle atrophy with aging is closely associated with chronic systemic inflammation and lifestyle-related diseases.
BACKGROUND : Muscle co-activation plays an important role in enhancing joint stability for movement regulation during motor learning activities.
BACKGROUND : Muscle impairment is a common condition in older people and a powerful risk factor for disability and mortality.
BACKGROUND : Muscle mass and strength are strong determinants of a person's quality of life and functional independence with advancing age.
BACKGROUND : Muscle mass , intermuscular adipose tissue , and strength are important indicators of physical function.
BACKGROUND : Muscle morphology , age and gender may be determinants of muscle strength in older adults.
BACKGROUND : Muscle power is related to mobility function in older adults , and effective power production requires rapid neuromuscular activation.
BACKGROUND : muscle strength measured as handgrip strength declines with increasing age and predicts mortality.
Background Muscle support for the trunk is provided by the multifidi , erector spinae , psoas , and quadratus lumborum.
BACKGROUND : Musculoskeletal conditions and insufficient physical activity have substantial personal and economic costs among contemporary aging societies.
BACKGROUND : Musculoskeletal hand pain is common in the general population.
Background : Musculoskeletal pain is highly prevalent and limits mobility in older adults.
BACKGROUND : Mutations in leucine-rich repeat kinase @number@ ( LRRK2 ) contribute to both familial and idiopathic forms of Parkinson's disease ( PD ) .
BACKGROUND : Mutations in LRRK2 are the most common genetic cause of Parkinson's disease ( PD ) .
BACKGROUND : N-Acetylglucosamine ( GlcNAc ) and its derivates have been utilized in dietary supplements and for therapeutic development due to their unique characteristics.
BACKGROUND : Nalbuphine is an opioid analgesic agent widely used for control of mild-to-severe pain.
BACKGROUND : National differences in cognitive health of older adults provide an opportunity to shed light on etiological factors.
BACKGROUND : Natural compounds in grapes such as resveratrol are known for their antioxidant and anti-inflammatory properties.
BACKGROUND : Natural killer T ( NKT ) cells act as a bridge between innate and adaptive immune responses.
BACKGROUND : Navigation skills are required for performance of functional complex tasks and may decline due to aging.
BACKGROUND : Near-falls are a frequent , but not commonly studied , occurrence in the elderly Black population and may be related to prospective falls.
BACKGROUND : nearly @percent@ of older adults do not maintain recommended exercise levels emphasising the need for interventions that promote exercise.
BACKGROUND : Neck wrinkles are common , troublesome aesthetic deformities for which a limited number of treatments exist.
BACKGROUND : Negative attitudes adversely impact on patient care and outcomes.
BACKGROUND : Negative self-perceptions of aging among older adults have been associated with higher mortality in developed countries.
BACKGROUND : Negative views towards ageing and older adults may be a reason why nurses do not choose to work in gerontological nursing.
BACKGROUND : Neonatal asphyxia is one of the leading causes of death in newborn and permanent neurological disabilities in surviving children.
BACKGROUND : neopterin is a monocyte / macrophage-derived immune activation marker and its levels increase with age.
BACKGROUND : Networks of family and friends are a source of support and are generally associated with higher life satisfaction values among older adults.
BACKGROUND : Neural tissue alterations in Down syndrome are fully expressed at relatively late developmental stages.
BACKGROUND : Neuroimaging studies which investigate brain activity underlying declarative memory processes typically use artificial , unimodal laboratory stimuli.
BACKGROUND : Neuropsychiatric symptoms are common complaints of elderly persons.
BACKGROUND : Neuropsychological interventions have been mainly applied with clinical populations , in spite of the need of preventing negative changes across life span.
BACKGROUND : Neuropsychological testing is a prime criterion of good practice to document cognitive deficits in a rapidly aging population.
BACKGROUND : Neurosurgical patients are aging as the general population is becoming older.
BACKGROUND : New biomarkers may aid in preventive and end-of-life decisions in older adults if they enhance the prognostic ability of traditional risk factors.
BACKGROUND : New chemotherapy drugs should be investigated to improve survival of patients with advanced bladder cancer.
BACKGROUND : Newly arriving asylum seekers in many European Union countries are assigned a place of residence based on administrative quota.
BACKGROUND : Newly established blood DNA methylation markers that are strongly associated with smoking might open new avenues for lung cancer ( LC ) screening.
BACKGROUND : New melanoma therapies , like e.g. ipilimumab , improve survival.
BACKGROUND : New-onset atrial fibrillation ( AF ) after coronary artery bypass graft ( CABG ) operation is associated with poorer survival.
BACKGROUND : New or increased impairments may develop several decades after an acute poliomyelitis infection.
BACKGROUND : New technologies for gait assessment are emerging and have provided new avenues for accurately measuring gait characteristics in home and clinic.
BACKGROUND : Nitric oxide ( NO ) is a messenger implicated in the destruction and inflammation of joint tissues.
BACKGROUND : Nitric oxide ( NO ) is a modulator of left ventricular hypertrophy ( LVH ) and myocardial relaxation.
BACKGROUND : Nitric oxide ( NO ) is a pleiotropic messenger molecule.
BACKGROUND : No consensus exists about methods of measuring nursing home ( NH ) length-of-stay for Medicare beneficiaries to identify long-stay and short-stay NH residents.
BACKGROUND : Nocturnal hypoglycemia was a common and serious problem among patients with type @number@ diabetes ( T2DM ) , especially in the elderly.
BACKGROUND : Nonablative fractionated laser resurfacing improves the texture of treated skin , but little is known about the molecular mechanisms that underlie clinical improvements.
BACKGROUND : Non-adherence to cardiovascular medications is a problem worldwide , even in Australia , which has a socialized medical system , Medicare.
BACKGROUND : Non-diabetic offspring from long-lived parents benefit from lowered CV risk.
BACKGROUND : Noninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment ( aMCI ) before measurable changes in behavioral performance remain scarce.
BACKGROUND : Non-invasive , easily administered nutritional screening tools for community dwelling older adults are few and those that are available are problematic.
BACKGROUND : non-participation in epidemiological studies threatens the generalisability of findings.
BACKGROUND : Non-pharmacological interventions for persons with dementia often rely on family caregivers for implementation.
BACKGROUND : non-steroidal anti-inflammatory drugs ( NSAIDs ) are used commonly to treat osteoarthritis in older patients.
BACKGROUND : No previous reports to date have characterized the national profiles of bone sarcoma overall.
BACKGROUND : Normal aging is associated with a decline in cognitive abilities , particularly in the domains of psychomotor speed and executive functioning.
BACKGROUND : Normal \ "wear and tear \ " of bones during weight bearing activity creates microdamage that triggers bone to heal itself.
BACKGROUND : No studies have estimated disability-adjusted life-years ( DALYs ) lost due to hip fractures using real-life follow-up cohort data.
BACKGROUND : No study has examined dopamine D₂ / ₃ receptor ( D₂ / ₃R ) availability in antipsychotic-free older patients with schizophrenia.
BACKGROUND : no study has examined the longitudinal association between hand-grip strength and mental health , such as depressive symptoms.
BACKGROUND : No target therapies are presently available in the treatment of small-cell lung cancer ( SCLC ) .
BACKGROUND : NSAIDs are commonly used in the elderly and carry significant risks of adverse events when used concomitantly with potentially interacting drugs.
BACKGROUND : N-terminal pro-brain natriuretic peptide ( NT-proBNP ) is associated with an increased risk of cardiac insufficiency , which possibly leads to heart failure.
BACKGROUND : @number@ lung transplantations were performed in Germany in @number@
BACKGROUND : Numeracy refers to people's ability to use numbers.
BACKGROUND : Numerous studies suggesting the relation between self-rated health ( SRH ) and depression have been reported using different measures.
BACKGROUND : Numerous studies suggest that higher coffee consumption may reduce the rate of aging-related cognitive decline in women.
BACKGROUND : Nurses have the key roles to detect delirium in hospitalized older patients but under-recognition of delirium among nurses is prevalent.
BACKGROUND : Nursing home residents are mainly older people with multiple diseases and taking multiple medications.
BACKGROUND : Nursing home residents often have pain as their everyday experiences and experience pain in silence.
BACKGROUND : Nursing home residing older adults often experience fear of sickness or death , functional impairment and pain.
BACKGROUND : Nutrient-related anemia among postmenopausal women is preventable ; recent data on prevalence are limited.
BACKGROUND : Nutrigenetics studies the role of genetic variation on interactions between diet and health , aiming to provide more personalized dietary advice.
BACKGROUND : Nutritional assessment commonly includes multiple nutrition indicators ( NIs ) .
BACKGROUND : Nutritional parameters could influence self-perceived health and functional status of older adults.
BACKGROUND : Nutritional risk is relatively common in community-dwelling older people.
BACKGROUND : Nutritional risk screening is typically done in clinical settings to identify individuals at risk of malnourishment.
Background : Nutritional supplementation and physical activity have been shown to positively influence muscle mass and strength in older adults.
BACKGROUND : Nutrition clubs ( NC ) operate in community settings and provide members with nutrition education and meal replacements for weight management.
BACKGROUND : Obese men commonly have reductions in circulating testosterone and report symptoms consistent with androgen deficiency.
BACKGROUND : Obesity and insulin resistance are associated with neuropathology and cognitive decline in Alzheimer's disease ( AD ) .
BACKGROUND : Obesity and low CRF are well-established risk factors for HF.
BACKGROUND : Obesity and obesity-related comorbidities are increasing among older adults.
BACKGROUND : Obesity , comorbid with pain disorders including migraine , shares common pathophysiological characteristics including systemic inflammation , and derangements in adipose-tissue derived cytokines.
BACKGROUND : Obesity has been consistently associated with dementia.
BACKGROUND : Obesity is a complex multifactorial disease , which also has an impact on quality of life.
BACKGROUND : Obesity is a risk factor for decline in glomerular filtration rate ( GFR ) .
BACKGROUND : Obesity is a risk factor for diabetes and its consequences , including accelerated ageing and mortality.
BACKGROUND : Obesity is a risk factor for disability , but risk of specific adipose depots is not completely understood.
BACKGROUND : Obesity is associated with an increased incidence of left ventricular hypertrophy , diastolic dysfunction , heart failure , and atherosclerosis.
BACKGROUND : Obesity is associated with incident HF , but it is paradoxically associated with better prognosis during chronic HF.
BACKGROUND : Obesity is associated with increased mortality , and weight loss trials show rapid improvement in many mortality risk factors.
BACKGROUND : Obesity is a well-established risk factor for incisional hernia development.
BACKGROUND : Obesity is one of the major public health challenges worldwide.
BACKGROUND / OBJECTIVE : Advanced PD is often associated with cognitive impairment and frequent falls.
BACKGROUND / OBJECTIVE : Despite the aging population , few studies have documented the treatment of geriatric psoriasis.
BACKGROUND / OBJECTIVE : High-dose estrogen treatment to reduce final height of tall girls has been shown to interfere with fertility.
BACKGROUND : objective measures are needed to quantify dietary adherence during caloric restriction ( CR ) while participants are freeliving.
BACKGROUND : Objective measures of loneliness and poor social contacts are associated with negative health outcomes.
BACKGROUND & OBJECTIVE : One of the most important challenges in public health is to improve the quality of life in elders.
BACKGROUND / OBJECTIVES : A previous fall is a strong predictor of future falls.
BACKGROUND / OBJECTIVES : As populations are ageing , more emphasis is placed on healthy ageing.
BACKGROUND / OBJECTIVES : Elderly with functional disabilities are at increased risk of inadequate dietary intake.
BACKGROUND / OBJECTIVES : Geriatric patients are highly susceptible to infections.
BACKGROUND / OBJECTIVES : It is unknown if wine , beer and spirit intake lead to a similar association with diabetes.
BACKGROUND / OBJECTIVES : Longitudinal studies have shown an increase in cognitive decline many years before clinical diagnosis of dementia.
BACKGROUND / OBJECTIVES : Low blood levels of 25-hydroxyvitamin D ( 25OHD ) have been associated with cardiometabolic disease but results are inconsistent.
BACKGROUND / OBJECTIVES : Nursing homes become important locations for palliative care.
BACKGROUND / OBJECTIVES : Nutrition screening should be initiated on hospital admission by non-dietitians.
BACKGROUND / OBJECTIVES : One phenomenon of skin aging is loss of cutaneous elasticity.
BACKGROUND / OBJECTIVES : Poor appetite in older adults leads to sub-optimal food intake and increases the risk of undernutrition.
BACKGROUND / OBJECTIVES : Post-marketing comparative trials describe medication use patterns in diverse , real-world populations.
BACKGROUND / OBJECTIVES : Predictors of healthy aging have not been well-studied using longitudinal data with demographic , clinical , subclinical , and genetic information.
BACKGROUND / OBJECTIVES : Previous studies have demonstrated that sun-induced alteration of epidermal permeability barrier function varies with gender and age.
BACKGROUND / OBJECTIVES : Rates of obesity are greatest in middle age.
BACKGROUND / OBJECTIVES : Slowing of motor performance in human aging is a well demonstrated clinical observation.
BACKGROUND / OBJECTIVES : Telomere shortening has an important role in cellular aging.
BACKGROUND / OBJECTIVES : The impact of pain on the physical performance of patients in aged care rehabilitation is not known.
BACKGROUND : OBJECTIVES : To determine the DTA of the SEARCH METHODS : This review is current to @date@ .
Background / Objective : studies on the association of dementia with specific body composition ( BC ) components are scarce.
BACKGROUND / OBJECTIVES : Vitamin D deficiency is associated with cardiovascular disease , osteoporosis , poor muscle strength , falls , fractures and mortality.
BACKGROUND / OBJECTIVE : The purpose of this study was to investigate changes in dietary intake and appetite across the menopausal transition.
BACKGROUND & OBJECTIVE : White matter hyperintensities ( WMHs ) contribute to aggravation of dementia or geriatric syndrome , thereby resulting in functional impairment.
BACKGROUND : Observational studies in older subjects have shown no or inverse associations between cholesterol levels and mortality.
BACKGROUND : Observational studies investigating the association between smoking , cognitive decline and dementia have produced conflicting results.
BACKGROUND : Observations that eyelashes become thinner , shorter , and lighter , as women age has not been previously quantified.
BACKGROUND : Obstructive sleep apnea ( OSA ) is associated with increased oxidative stress.
BACKGROUND : Occupations , including physical activity , are a strong determinant of health.
BACKGROUND : Occurrence and progression of age-related irreversible degradations of skeletal joints , osteoarthritis ( OA ) , has a stochastic nature.
BACKGROUND : Occurrence of musculoskeletal pain in dance sport dancers is often a cause for longer discontinuation of training , which affects the competition results.
BACKGROUND : Of all age groups , older adults spend the most time watching TV , which is one of the most common sedentary behaviours.
BACKGROUND : offspring of long-lived individuals have lower risk for dementia.
BACKGROUND : Often preventive measures are not accessed by the people who were intended to be reached.
BACKGROUND : Old age and hypertension are consistently reported to be the main risk factors of leukoaraiosis.
BACKGROUND : Old age carries a markedly increased risk of osteoporotic fractures with subsequent disability , dependency and premature death.
BACKGROUND : Older adults are encouraged by many organizations to engage in advance care planning in the event of decisional incapacity.
BACKGROUND : Older adults are more likely to live alone , because they may have been predeceased by their spouse and friends.
BACKGROUND : Older adults are more susceptible to adverse events when administered certain medications at doses appropriate for younger adults.
BACKGROUND : Older adults are the fastest growing segment of the world's population.
BACKGROUND : Older adults can benefit from physical activity in numerous ways.
BACKGROUND : Older adults comprise a vulnerable population for social isolation and its associated health risks.
BACKGROUND : Older adults face important risky decisions about their health , their financial future , and their social environment.
BACKGROUND : Older adults frequently experience pressure ulcers ( PrUs ) and suffer the risks of the ulceration.
BACKGROUND : Older adults have more chronic medical conditions , and the level of polypharmacy increases with advancing age.
BACKGROUND : Older adults ' health maintenance may be enhanced by having access to online health information.
BACKGROUND : Older adults manifest difficulties in speech perception , especially when speech is accompanied by noise or when speech is rapid.
BACKGROUND : Older adults often elect to move into smaller living environments.
BACKGROUND : Older adults often use complementary medicine ; however , very few interventional studies have focused on them.
BACKGROUND : Older adults report preservation of functional independence as one of the most important constructs of successful ageing.
BACKGROUND : Older adults undergo operations as our population ages.
BACKGROUND : Older adults with amnestic mild cognitive impairment ( aMCI ) are at higher risk for developing Alzheimer disease.
BACKGROUND : Older adults with dementia are vulnerable to the central deteriorating effects of drugs with anticholinergic properties ( DAPs ) .
BACKGROUND : Older adults with hearing difficulties face problems of communication which may lead to underuse of health services.
BACKGROUND : Older adults , with or without normal peripheral hearing sensitivity , have difficulty understanding speech.
BACKGROUND : Older drivers aged ≥70 years old have among the highest rates of motor vehicle collisions ( MVC ) compared to other age groups.
BACKGROUND : Older hip fracture patients have a high probability of falling again after a fall incident.
BACKGROUND : Older Indigenous adults encounter multiple challenges as their age intersects with health inequities.
BACKGROUND : Older injured persons are frequently undertriaged , increasing the risk for preventable mortality and morbidity in an already-vulnerable population.
BACKGROUND : Older inpatients are at risk of hospital-associated geriatric syndromes including delirium , functional decline , incontinence , falls and pressure injuries.
Background Older non-small cell lung cancer ( NSCLC ) patients under erlotinib are reported to experience more acute toxicity.
BACKGROUND : Older nurses are working longer and beyond the usual retirement age.
BACKGROUND : Older patients are prone to multimorbidity and polypharmacy , with an inherent risk of adverse events and drug interactions.
BACKGROUND : Older people are a growing sub-group in global populations who regularly interface with nurses.
BACKGROUND : Older people are exposed to multiple medicines that possess anticholinergic properties.
BACKGROUND : Older people constitute a significant proportion of the total population and their number is projected to increase by more than half by @number@
BACKGROUND : Older people have the highest incidence of acute medical admissions.
BACKGROUND : Older people's quality of life can be improved by preparing for the transition into old age.
BACKGROUND : Older people who increase or maintain their physical activity have lower mortality than those who remain sedentary.
BACKGROUND : Older persons ' right to exercise self-determination in daily life is supported by several laws.
BACKGROUND : Older women with low back pain ( LBP ) constitute a special subpopulation at risk of severe and permanent disability.
BACKGROUND : Old-old age ( 80 + years ) is associated with substantial cognitive decline.
BACKGROUND : Olfactory disorders increase with age and often affect elderly people who have pre-dementia or dementia.
Background : Olfactory dysfunction ( OD ) in old age is associated with poor health outcomes.
Background : Olfactory impairment is common among older adults ; however , data are largely limited to whites.
BACKGROUND : Onabotulinumtoxin A has been used for many years in the aging face treatment.
BACKGROUND : OnabotulinumtoxinA is an established treatment for glabellar frown lines , but its effects on lines at repose are less well documented.
BACKGROUND : Onabotulinumtoxin A ( onabotulinum ) has been used for @number@ years in the treatment of the aging face.
BACKGROUND : On average , as people age , they accumulate more health deficits and have an increased risk of death.
BACKGROUND : On @date@ , Taiwan expanded its smoke-free legislation to all indoor public places and workplaces.
BACKGROUND : One important goal of paediatric occupational therapy services is to improve activities of daily living ( ADL ) abilities of children.
BACKGROUND : One of the hallmarks of haptic exploration is that it typically involves movement between skin and object.
Background : Only scarce data exist on the association between obesity and disability in the oldest old.
BACKGROUND : Open surgical revascularization has been considered the historical gold standard treatment for mesenteric ischemia though it poses considerable morbidity and mortality risk.
BACKGROUND : Optical coherence tomography ( OCT ) of the anterior segment allows quantitative analysis of the geometry of the chamber angle.
BACKGROUND : Oral bisphosphonates ( BPs ) are the primary agents for the treatment of osteoporosis.
BACKGROUND : Oral health among the higher educated is known to be better than among the less-well educated.
BACKGROUND : Oral health has been found to be associated with cognitive function in basic research and epidemiology studies.
BACKGROUND : Oral health status and oral health problems can affect eating habits and thus consequently the nutritional status of frail older people.
BACKGROUND : Oral iron supplementation is used widely in older people despite observational studies suggesting it is ineffective.
BACKGROUND : Oral isotretinoin ( ISO ) is the only drug which promotes prolonged remission or cure of severe acne.
BACKGROUND : Oronasal fistulas after oromaxillary surgery may sometimes be encountered and remain a challenging problem.
BACKGROUND : Orthostatic hemodynamic signals may predict adverse outcomes in elders.
BACKGROUND : Orthostatic hypotension ( OH ) is commonly reported among older adults and is associated with an increased risk of mortality.
BACKGROUND : Osteoarthris represents one of the most frequent degenerative pathologies.
BACKGROUND : Osteoarthritis ( OA ) is a common problem in elderly , but it is not an inevitable feature of ageing.
BACKGROUND : Osteoarthritis ( OA ) is the most common form of human polyarthritis.
BACKGROUND : Osteoporosis is a significant health problem , especially for older women.
BACKGROUND : Osteoporosis is pathophysiologically related to trochanteric fractures , and this condition is more preventable by lifestyle modifications than cervical fractures.
BACKGROUND : Overexposure to solar radiation is a major contributor to skin cancer development and premature skin aging.
BACKGROUND : Over @number@ trials show that patient decision aids effectively improve patients ' information comprehension and values-based decision making.
BACKGROUND : Over the past decade injectable hyaluronan ( HA ) formulations have been widely used to decrease the visibility of skin aging.
BACKGROUND : Over three-quarters of the older population take medications that can potentially cause dry mouth.
BACKGROUND : Overtriage has been observed among pediatric patients in emergency departments ( EDs ) under 5-level acuity pediatric triage systems.
BACKGROUND : Overweight and obese older adults have high sedentary time.
BACKGROUND : Overweight and obesity in childhood have been linked to an increased risk of adult mortality , but evidence is still scarce.
BACKGROUND : Oxidative stress activates endothelial innate immunity and disrupts endothelial functions , including endothelial nitric oxide synthase-derived nitric oxide bioavailability.
BACKGROUND : Oxidative stress is strongly associated with aging and age-related diseases and plays a crucial role in endothelial dysfunction development.
BACKGROUND : Ozone concentrations in ambient air are related to cardiopulmonary perturbations in the aging population.
BACKGROUND : Pachydermoperiostosis ( PDP ) is a rare hereditary disorder characterized by digital clubbing , periostosis , and pachydermia.
BACKGROUND : PA has been related to lower risk for AD.
Background : Pain has been suggested to act as a stressor during aging , potentially accelerating declines in health and functioning.
BACKGROUND : Pain is common in older people , particularly those in residential aged care facilities ( RACF ) and those with dementia.
BACKGROUND : Palliative care competencies in surgical training are recognized to improve the care of surgical patients with advanced or life-threatening illnesses.
BACKGROUND : Palliative care stakeholders recently included more groups in their definition of palliative care ; older people constitute one such group.
BACKGROUND : Pancreatic cancer is a disease of older adults , who may present with limited physiologic reserve.
BACKGROUND : Pancreatic fistula ( PF ) after pancreatoduodenectomy ( PD ) represents the major source of morbidity.
BACKGROUND : Parabens are preservatives commonly used in personal care products , pharmaceuticals , and foods.
BACKGROUND : Paracetamol , a commonly used simple analgesic , can be fatal in overdose.
BACKGROUND : Parental longevity confers lower risks for some age-related diseases in offspring.
BACKGROUND : Parkinson's disease is characterized by motor and non-motor symptoms with wide ranging impacts on the health-related quality of life.
BACKGROUND : Parkinson's disease is the second most common neurodegenerative disorder for which old age is the best known risk.
BACKGROUND : Parkinson's disease ( PD ) is a late-life neurodegenerative disease.
BACKGROUND : Participation in regular physical activity is associated with a multitude of health benefits across the life course.
BACKGROUND : Participation of older people in a program of regular exercise is an effective strategy to minimize the physical decline associated with age.
BACKGROUND : Patient age is one of many potential risk factors for fracture nonunion.
BACKGROUND : Patient information leaflets ( PILs ) are the most important information source for older patients to effectively manage their drug therapy.
BACKGROUND : Patient-reported outcomes ( PROs ) are important assessment benchmarks after aesthetic procedures.
BACKGROUND : Patients aged @number@ years and older have important oral health needs , but their oral management may differ according to their immediate environment.
BACKGROUND : Patients discharged home after stroke face significant challenges managing residual neurological deficits , secondary prevention , and pre-existing chronic conditions.
BACKGROUND : Patients on hemodialysis present an increased risk of cardiovascular death.
BACKGROUND : Patients undergoing cardiac surgery have a high frequency of preexisting cerebral ischemic lesions , the presence of which appears to predict cognitive sequelae.
BACKGROUND : Patients undergoing emergency gastrointestinal surgery for intra-abdominal infection are at risk of invasive candidiasis ( IC ) and candidates for preemptive antifungal therapy.
BACKGROUND : Patients who are aging , with weight gain , and increased skin laxity , request dermatologists to improve their neck area.
BACKGROUND : Patients who suffer from scars or wrinkles have several therapeutic options to improve the appearance of their skin.
BACKGROUND : Patients who undergo tricuspid annuloplasty during left-side heart valve surgery have a poor postoperative clinical outcome.
BACKGROUND : Patients with advanced heart failure run a greater risk of dementia.
BACKGROUND : Patients with Alzheimer's disease ( AD ) who deteriorate rapidly are likely to have a poorer prognosis.
BACKGROUND : Patients with chronic atherosclerotic vessel occlusion and cerebrovascular hemodynamic insufficiency may benefit from extra-intracranial ( EC-IC ) bypass surgery.
BACKGROUND : Patients with coronary spastic angina ( CSA ) also have endothelial dysfunction and inflammation.
BACKGROUND : Patients with multimorbidity are an increasing concern in healthcare.
BACKGROUND : Patients with Parkinson disease ( PD ) experience problems such as falls and freezing of gait during walking and turning in daily activities.
BACKGROUND : Patients with severe space-occupying so-called malignant middle cerebral artery infarcts have a poor prognosis even under maximum intensive care treatment.
BACKGROUND : Patients with stress-related exhaustion suffer from cognitive impairments , which often remain after psychological treatment or work place interventions.
BACKGROUND : Patterns of crow's feet lines ( CFLs ) vary among individuals.
BACKGROUND : Peanut allergy is relatively common among children in developed countries and may have severe outcomes , including anaphylaxis.
BACKGROUND : Pedestrian injuries among older people tend to occur near their residence.
BACKGROUND : Pedometers are more likely than accelerometers to be used in walking interventions and other applications , including wide spread adoption by lay people.
BACKGROUND : Peeling is a procedure which aims to accelerate the process of skin exfoliation.
BACKGROUND : Pentacyclic triterpenoids improve epidermal barrier function and induce collagen production.
BACKGROUND : People aging with HIV show variable health trajectories.
BACKGROUND : People who are physically active have at least a @percent@ lower risk of death during follow-up compared with those who are inactive.
BACKGROUND : People with dementia are sensitive to cognitive side effects of anticholinergic drugs.
BACKGROUND : People with Down syndrome ( DS ) often have sleep-disordered breathing ( SDB ) .
BACKGROUND : Performance-based and self-report instruments of physical function are frequently used and provide complementary information.
BACKGROUND : Perianal fistula is a complex and frequent disease.
BACKGROUND : Perinatal complications predict increased risk for morbidity and early mortality.
BACKGROUND : Periodontitis and Alzheimer disease ( AD ) are associated with systemic inflammation.
BACKGROUND : Periostin is a secreted 90kDa matricellular protein , which is predominantly expressed in collagen-rich tissues.
BACKGROUND : Peripheral venous catheterization is frequently associated with phlebitis.
BACKGROUND : Peroxisome proliferator-activated receptor-γ co-activator ( PGC ) -1α is a transcriptional co-activator of antioxidant genes and a master regulator of mitochondrial biogenesis.
BACKGROUND : Personalised medicine involves customising management to meet patients ' needs.
BACKGROUND : Personality disorder traits are relatively prevalent among older adults , and can be associated with complex and chronic difficulties , including suicide risk.
BACKGROUND : Phase angle measured by bioelectrical impedance analysis ( BIA ) may be a marker of health state.
BACKGROUND : Photoaging of the hands is common due to frequent exposure to environmental factors.
BACKGROUND : Photo documentation has become increasing important in medicine , especially given the demand for cosmetic procedures.
BACKGROUND : Photodynamic therapy ( PDT ) is a safe and effective treatment for actinic keratoses ( AKs ) and photoactinic damage.
BACKGROUND : Phototrichogram analysis of normal scalp hair characteristics in Asian populations is not well characterized.
BACKGROUND : Physical activity affects physical and mental health , prevents disease , and improves quality of life.
BACKGROUND : Physical activity and sitting time independently contribute to chronic disease risk , though little work has focused on aspirational health outcomes.
BACKGROUND : Physical activity has a pleiotropic effect and is a significant factor in successful aging.
BACKGROUND : Physical activity has good influence on health.
BACKGROUND : Physical activity is an essential ingredient in the recipe for successful aging , yet physical activity engagement declines with advancing age.
BACKGROUND : Physical activity is associated with improved overall health in those people who survive to older ages , otherwise conceptualised as healthy ageing.
BACKGROUND : Physical activity is important for maintaining independence and quality of life in older people living in care homes.
BACKGROUND : Physical activity is one of the most important contributors to healthy aging.
BACKGROUND : physical activity ( PA ) is an important factor to promote healthy ageing.
BACKGROUND : Physical activity ( PA ) is beneficial in improving negative physical and psychological effects of cancer.
BACKGROUND : Physical activity ( PA ) levels of older adults living in a care setting are known to be very low.
BACKGROUND : Physical activity promotes health in older adults but participation rates are low.
BACKGROUND : Physical and cognitive activity seems to be an effective strategy by which to promote age-sensitive fluid cognitive abilities in older adults.
BACKGROUND : Physical decline and high rates of inactivity lead to an increased risk of falling in the intellectual disability ( ID ) population.
BACKGROUND : Physical frailty is a prevalent syndrome in older adults that increases vulnerability for a range of adverse outcomes including increased dependency and death.
BACKGROUND : Physical frailty ( PF ) and sarcopenia are predictors of negative health outcomes such as falls , disability , hospitalization , and death.
Background : Physical function decline is a major public health concern and can predict later mortality.
BACKGROUND : physical functioning describes the underlying abilities that make activities necessary for independent living in the community possible.
Background : Physical function ( PF ) impairment and elder mistreatment ( EM ) are alarming public health issues facing by many older adults.
BACKGROUND : Physical impairments and activity restrictions cause significant morbidity after surgery for sarcoma.
BACKGROUND : Physical inactivity accounts for @percent@ of all deaths worldwide and is among the top @number@ risk factors for global disease burden.
BACKGROUND : Physical inactivity across the lifespan remains a public health issue for many developed countries.
BACKGROUND : Physical inactivity is a significant predictor of several chronic diseases , becoming more prevalent as people age.
BACKGROUND : Physical inactivity is one of the leading causes of chronic disease in Canadian adults.
BACKGROUND : Physical inactivity plays a central role in the age-related decline in muscle strength , an important component in the process leading to disability.
BACKGROUND : Physical occupational exposure is a risk factor for low back pain in workers but the long term effects of exposure remain unclear.
Background : physical performance is a key factor that determines how older people cope with daily tasks and maintain independency.
BACKGROUND : Physical performance is a major determinant of health in older adults , and is related to lifestyle factors.
BACKGROUND : Physical performance may predict survival independently of other current predictors in non selected elderly subjects.
BACKGROUND : Physical performance often declines in middle age , but it is unclear to what extent this is due to biological aging.
BACKGROUND : Physician Orders for Life-Sustaining Treatment ( POLST ) forms are used to document patient treatment preferences as medical orders.
BACKGROUND : Physicians face the challenge of individualizing aesthetic treatments in order to match the aesthetic needs of patients with their expectations.
BACKGROUND : Physicians often begin the physical examination with an assessment of whether a patient looks older than his or her actual age.
BACKGROUND : Placebo responses raise significant challenges for the design of clinical trials.
BACKGROUND : Placental mammals display a huge range of life history traits , including size , longevity , metabolic rate and germ line generation time.
BACKGROUND : Platelet activation is involved in acute coronary syndromes ( ACS ) .
BACKGROUND : Pneumococcal urinary antigen test is a valuable tool for diagnosing pneumococcal pneumonia and meningitis in adults.
BACKGROUND : Pneumonia following endoscopic procedures may affect the clinical course and prolong hospital stay.
BACKGROUND : Polyalkylimide is a nonresorbable , biocompatible polymeric filler that has been used for several years to treat soft tissue deficits.
BACKGROUND : Polycystic ovary syndrome ( PCOS ) represents a moving spectrum of hormonal to metabolic abnormalities , as women with the syndrome are aging.
BACKGROUND : Polypharmacy and hyperpolypharmacy are proxy indicators for inappropriate medicine use.
BACKGROUND : Polypharmacy and inappropriate drug use is associated with negative health outcomes among older people.
BACKGROUND : Polypharmacy and potentially inappropriate drugs have been associated with negative outcomes in older adults which might be reduced by pharmacist interventions.
BACKGROUND : Polyunsaturated fatty acids and fish may influence bone health.
BACKGROUND : POMONA II was a European Commission public health-funded project.
BACKGROUND : Pooled library screen analysis using shRNAs or CRISPR-Cas9 hold great promise to genome-wide functional studies.
BACKGROUND : Poor food intake is common in acute care patients and can exacerbate or develop into malnutrition , influencing both recovery and outcome.
BACKGROUND : Poor growth and micronutrient deficiency mainly attack older infants and young children.
BACKGROUND : Poor nutritional status is often present among older adults who experience a fall.
BACKGROUND : Poor oral health is associated with an increased risk of dementia in the elderly.
BACKGROUND : Poor self-rated health has been associated with poorer objective health outcomes across a range of conditions including stroke.
BACKGROUND : Poor vitamin D status can increase age-related muscle mass loss.
BACKGROUND : Poor vitamin K status is linked to greater risk of several chronic diseases.
BACKGROUND : Poor work ability correlates with increased morbidity and early retirement from the workforce , but the association in old age is not known.
BACKGROUND : Population ageing is a worldwide phenomenon that has recently challenged public healthcare systems.
BACKGROUND : population ageing will lead to a leap in the dementia population in Asia.
BACKGROUND : Population aging and the incremental use of high-tech instruments increase the demand for radiological examinations and treatments in medical services.
BACKGROUND : Population aging increases the number of glaucoma patients which leads to higher workloads of glaucoma specialists.
BACKGROUND : Population aging increases the prevalence of chronic diseases.
BACKGROUND : Population aging is a global phenomenon whose main consequence is the increase of chronic degenerative diseases , including dementia.
BACKGROUND : Population aging is closely related to high prevalence of chronic conditions in developed countries.
BACKGROUND : Population aging is expected to result in a substantial additional burden on healthcare resources in the near future.
BACKGROUND : Population aging poses significant challenges to primary care providers and healthcare policy makers.
BACKGROUND : Population is aging rapidly in Europe.
BACKGROUND : Portal hypertension , a major complication of hepatic fibrosis , can affect the stiffness of the spleen.
BACKGROUND : Portal vein occlusion ( PVO ) is used to increase inadequate future liver remnant volume ( FLRV ) .
BACKGROUND : Positive affect contributes to the healthy life style , which , in turn , explains life satisfaction and psychological well-being among the elderly.
BACKGROUND : Positive life orientation ( PLO ) is considered an important dimension of successful aging.
BACKGROUND : Postexercise protein or amino acid ingestion restores muscle protein synthesis in older adults and represents an important therapeutic strategy for aging muscle.
BACKGROUND : Post-mortem studies have not identified an association between β-amyloid or tau and rates of hippocampal atrophy in patients with Alzheimer's disease.
BACKGROUND : Postoperative pain and opioid use are associated with postoperative delirium.
BACKGROUND : Postoperative residual neuromuscular blockade ( RNMB ) is associated with significant morbidity.
Background : Postpartum hepatitis C viral ( HCV ) load decline followed by spontaneous clearance has been previously described.
BACKGROUND : Postponing parenthood has steadily increased during the past decades in Western countries.
BACKGROUND : Posttraumatic stress disorder ( PTSD ) is associated with increased risk for age-related diseases and early mortality.
BACKGROUND : Postural balance and potentially fall risk increases among older adults living with neurological diseases , especially Parkinson's disease ( PD ) .
BACKGROUND : Postural control is an important aspect of physical functioning.
BACKGROUND : Postural instability ( PI ) in Parkinson's disease ( PD ) is associated with depression and apathy based on UPDRS scores.
BACKGROUND : Potentially inappropriate medications ( PIMs ) should be avoided by the aged population.
BACKGROUND : Precise factors associated with premature skin aging , or photoaging , in the general population are unknown.
BACKGROUND : Precise implantation of soft tissue fillers to treat the signs of aging is crucial for patient safety and the best aesthetic outcome.
BACKGROUND : Prediction of long-term survival in healthy adults requires recognition of features that serve as early indicators of successful aging.
BACKGROUND : Preeclampsia is a major cause of maternal and fetal mortality , and its pathogenesis is not fully understood.
Background : Pregnancy outcomes of perinatally human immunodeficiency virus-infected women ( PHIV ) are poorly defined.
BACKGROUND : Pregnancy weight gain is believed to contribute to female overweight and obesity.
BACKGROUND : Premalignancies resulting from photodamage , such as actinic keratosis and carcinoma in situ , can be treated with various modalities.
BACKGROUND : Premature aging seriously compromises the health status of Down Syndrome ( DS ) persons.
BACKGROUND : Premature aging syndromes recapitulate many aspects of natural aging and provide an insight into this phenomenon at a molecular and cellular level.
BACKGROUND : Preoperative spirometry provides measurable information about the occurrence of respiratory disorders.
BACKGROUND : Prescription is a complex challenge facing clinicians caring for elderly inpatients.
BACKGROUND : Presenteeism is a growing problem in developed countries mostly due to an aging workforce.
BACKGROUND : preservation of cognitive abilities is required to have a good quality of life.
BACKGROUND : Preserving cognitive function is an important public health issue.
BACKGROUND : Pressure ulcers ( PUs ) are more frequent in older patients , and the healing process is usually challenging.
BACKGROUND : Pressure ulcers still remain a significant problem in many healthcare settings.
BACKGROUND : Preterm infants may have cardiac stress related to patent ductus arteriosus ( PDA ) or bronchopulmonary dysplasia ( BPD ) .
BACKGROUND : Prevalence of neurocognitive impairment in HIV-1 infected patients is reported to be high.
BACKGROUND : Preventing and / or delaying cognitive impairment is a public health priority.
BACKGROUND : Preventing falls is an international priority.
BACKGROUND : prevention of disability is an important aim of healthcare for older persons.
BACKGROUND : Prevention strategies for pressure ulcer formation remain critical in patients with an advanced illness.
BACKGROUND : Previous cross-sectional MRI studies with healthy , young-to-middle-aged adults reported no significant differences between smokers and non-smokers on total hippocampal volume.
BACKGROUND : Previous cross-sectional studies demonstrate positive associations of fat-free mass and negative associations of centrally distributed fat deposits with respiratory function in older adults.
BACKGROUND : Previous findings have demonstrated the link between trauma , its psychopathological aftermath and cellular aging , as reflected in telomere length.
BACKGROUND : Previous growth studies of Peruvian children have featured high stunting rates and limited information about body composition.
BACKGROUND : previously , frailty indices were constructed using mostly subjective health measures.
BACKGROUND : Previously we showed that @number@ weeks of mixed-low resistance training ( LOW + ) significantly increased circulating BDNF in older male individuals.
BACKGROUND : Previous research has demonstrated that employment-based benefits are important for the recruitment and retention of nursing assistants ( NAs ) .
BACKGROUND : Previous research has noted an age effect on the temporal integration of the acoustic reflex for a noise activator.
BACKGROUND : Previous research has revealed the existence of gender differences in sleep patterns among older adults from various ethnic groups.
BACKGROUND : Previous research indicates that total cholesterol levels increase with age during young adulthood and middle age and decline with age later in life.
BACKGROUND : Previous studies have demonstrated that gene expression levels change with age.
BACKGROUND : Previous studies have examined an association between sleep duration and hypertension , but the conclusions remain inconsistent.
BACKGROUND : Previous studies have found high levels of undetected psychological distress and unaddressed need among care home residents.
BACKGROUND : Previous studies have mostly focused on socio-demographic and health-related determinants of health-related behaviors.
BACKGROUND : Previous studies have reported significant deficits in emotion recognition among individuals along the frontotemporal dementia ( FTD ) spectrum.
BACKGROUND : Previous studies have reported that the indeterminable aging and long-duration occlusion are associated with procedural failure and adverse long-term outcome.
BACKGROUND : Previous studies have revealed that amyloid depositions exist in not only the hippocampus but in other subcortical gray matter structures as well.
BACKGROUND : Previous studies have shown adverse effects of CpG island methylator phenotype ( CIMP ) on colorectal cancer ( CRC ) prognosis.
BACKGROUND : Previous studies have shown an inconsistent relation between habitual beverage consumption and insulin resistance and prediabetes.
BACKGROUND : Previous studies have shown different relationships between traditional cardiovascular risk factors for coronary artery disease ( CAD ) in very elderly people.
BACKGROUND : Previous studies have shown that radiofrequency ( RF ) energy is safe and effective for improving skin laxity.
BACKGROUND : Previous studies have suggested that nut consumption is associated with beneficial cardiovascular outcomes.
BACKGROUND : Previous studies have thoroughly investigated the prevalence and risk factors for completed suicide.
BACKGROUND : Previous studies indicate that psychosocial factors can impact COPD prevalence.
BACKGROUND : Previous studies on nonagenarians have widely investigated functional and cognitive decline , falls , predictors of mortality , inflammation and aging genetics.
BACKGROUND : Previous studies suggest that the antioxidants vitamins C and E may protect against development of knee osteoarthritis ( OA ) .
BACKGROUND : Previous work demonstrated that a soy-dairy protein blend ( PB ) prolongs hyperaminoacidemia and muscle protein synthesis in young adults after resistance exercise.
BACKGROUND : Primary care physicians routinely provide dementia care , but may lack the clinical skills and awareness of available resources to provide optimal care.
BACKGROUND : Primary hyperparathyroidism is a common endocrine disease , and its incidence increases with age.
BACKGROUND : Primary hyperparathyroidism ( PHPT ) is often found on routine blood tests , at a relatively asymptomatic stage.
BACKGROUND : Primary malignant brain tumors ( PMBTs ) are devastating malignancies with poor prognosis.
BACKGROUND : Primary progressive aphasia ( PPA ) is an untreatable neurodegenerative disorder that disrupts language functions.
Background : Prior studies suggest being overweight may be protective against poor functional outcomes in older adults.
BACKGROUND : Prior work suggests that some but not all antihypertensive treatments may benefit cognition and risk for Alzheimer's disease , independent of stroke.
BACKGROUND : Prisons and jails are facing sharply increased demands in caring for aged and dying inmates.
BACKGROUND : Processing speed has been highlighted as a diagnostic item for neurocognitive disorders ( NCD ) in DSM-5.
BACKGROUND : Producing youthful facial appearance by face-lifting often comes along with an undesired loss of patient's individual phenotype.
BACKGROUND : Professional , non-invasive , anti-aging treatments based on radio-frequency ( RF ) technologies are popular for skin tightening and improvement of wrinkles.
BACKGROUND : Progeria is a rare fatal genetic condition characterized by an appearance of accelerated aging in children.
BACKGROUND : prognostication for frail older adults is complex , especially when they become seriously ill.
BACKGROUND : Prognostic value of immune cells is not clear in testicular germ cell tumors ( TGCTs ) .
BACKGROUND : Progressive supranuclear palsy ( PSP ) is a neurodegenerative extrapyramidal syndrome.
BACKGROUND : Projections of the national burden of cancer play a key role in planning cancer control programmes and investments.
BACKGROUND : Pronounced nasojugal groove ( tear trough deformity ) is one of the landmarks of aging.
BACKGROUND : Proprioception can be assessed by measuring joint position sense ( JPS ) .
BACKGROUND : Prospective memory , or remembering to do things in the future , is crucial for independent living in old age.
BACKGROUND : Prospective memory ( ProM ) is the ability to become aware of a previously-formed plan at the right time and place.
BACKGROUND : Prospective memory refers to memory for future intentions and is a critical predictor of functional capacity in late adulthood.
BACKGROUND : Prostatic enlargement is a common cause of bladder outlet obstruction in men in Nigeria.
BACKGROUND : Protein anabolism in response to feeding may be impaired with aging.
BACKGROUND : Protein intake has been inversely associated with frailty.
BACKGROUND : Proximal humeral fractures are mainly associated with osteoporosis and are becoming more common with the aging of our society.
BACKGROUND : PSP is a neuropathologically defined disease entity.
BACKGROUND : Psychache can and does co-exist alongside resilience and coping amongst trauma survivors.
BACKGROUND : Psychological stress increases the circulating levels of the stress hormones cortisol and norepinephrine ( NE ) .
BACKGROUND : Psychophysical evidence indicates age-related decline over a broad range of auditory abilities.
BACKGROUND : Psychosocial stress has been associated with an increased risk for mental and somatic health problems across the life span.
BACKGROUND : Ptosis of the earlobe is a common consequence of ageing , defined as an unappealingly large free caudal segment of over @number@ mm.
BACKGROUND : Puberty and reproductive hormones have been identified as having a potential role in schizophrenia.
BACKGROUND : Public health initiatives world-wide recommend increasing physical activity ( PA ) to improve health.
BACKGROUND : Public policies aim to promote well-being , and ultimately the quality of later life.
BACKGROUND : Published guidelines for treatment of type @number@ diabetes mellitus ( T2DM ) agree on initial pharmacotherapy.
BACKGROUND : Published research studies have described the existence of @number@ glabellar contraction patterns.
BACKGROUND : Published studies assessing whether asymmetrical facial ultraviolet light exposure leads to underlying differences in skin physiology and morphology report only clinical observations.
BACKGROUND : Published studies indicate that depression in older adults is severely under-recognized and under-treated.
BACKGROUND : Pulmonary abnormalities are often present in patients infected with the human immunodeficiency virus ( HIV ) .
BACKGROUND : Punica granatum ( family : Lythraceae ) is mainly found in Iran , which is considered to be its primary centre of origin.
BACKGROUND / PURPOSE : Collagen is the major structural protein of the skin and its crosslinks are essential for its mechanical stability.
BACKGROUND / PURPOSE : Cushing's disease ( CD ) is the most common cause of endogenous Cushing's syndrome.
BACKGROUND / PURPOSE : Frailty is the core of geriatric syndromes in the elderly.
BACKGROUND / PURPOSE : Ginsenosides have many biomedical efficacies , such as anti-aging , antioxidation , and anti-inflammatory activities.
BACKGROUND / PURPOSE : Increased interest in antiaging methods , mandates a development of reliable noninvasive technique to assess skin aging.
BACKGROUND : Purpose in life is thought to be associated with positive health outcomes in old age , but its association with disability is unknown.
BACKGROUND / PURPOSE : Modern men have changed their beauty and grooming habits , which has resulted in an increasing demand for cosmetics for men.
BACKGROUND / PURPOSE : Perceived age may be a better predictor of mortality rate than chronological age.
BACKGROUND / PURPOSE : Skin aging can be classified into chronological aging and photoaging.
BACKGROUND / PURPOSE : Subcutaneous tissue is rarely studied in research on wrinkles.
BACKGROUND / PURPOSE : The most commonly used method to determine the mechanical ability of skin is the creep test using suction chamber devices.
BACKGROUND / PURPOSE : There are various non-invasive methods in skin morphology for assessing skin aging.
BACKGROUND / PURPOSE : Ultraweak photon emission ( UPE ) is one potential method to evaluate the oxidative status of the skin in vivo.
BACKGROUND : qualitative and quantitative changes in human mitochondrial DNA ( mtDNA ) have been implicated in various cancer types.
BACKGROUND : Quality of life has become an important aspect in the measurement of the health of an individual as the population ages.
BACKGROUND : Quantitative assessment of right ventricular ( RV ) function is important for the management of patients with congenital heart disease.
BACKGROUND : Quick step execution may prevent falls when balance is lost ; adding a concurrent task delays this function.
BACKGROUND : Racial differences in endogenous pain facilitatory processes have been previously reported.
BACKGROUND : Radioiodine ( 131I ) therapy is widely used for treatment of non-toxic goiters.
BACKGROUND : randomised controlled trials ( RCTs ) of falls prevention conducted in institutional settings have recently been systematically reviewed.
BACKGROUND : Randomized trial evaluated problem-solving therapy in home care ( PSTHC ) for homebound older adults with cardiovascular disease receiving acute home care services.
BACKGROUND : Rapid aging of the population worldwide necessitates a heightened concern about preventing cognitive decline.
BACKGROUND : Rapid Assessment for the Avoidable Blindness ( RAAB ) was conducted in Qatar during @number@
BACKGROUND : Rapidly evolving socioeconomic and technological trends make it challenging to improve access , effectiveness and efficiency in the use of pharmaceuticals.
BACKGROUND : RBD is a parasomnia that can develop in otherwise neurologically-normal adults as well as in those with a neurodegenerative disease.
BACKGROUND : Reablement is a rehabilitation intervention for community-dwelling older adults , which has recently been implemented in several countries.
BACKGROUND : Reactions to density and proximity are complex.
BACKGROUND : Reactive oxygen species are known to mediate skin photoaging , which results in the formation of pigmented spots and wrinkles.
BACKGROUND : Reactive oxygen species production is the final step in skin aging.
BACKGROUND : Readmissions in patients with chronic obstructive pulmonary disease ( COPD ) are common and costly.
BACKGROUND : Recent attention has focused on the negative effects of chemotherapy on the cognitive performance of cancer survivors.
BACKGROUND : Recent evidence has indicated that flavanol consumption may have many health benefits in humans , including improved cognitive activities.
BACKGROUND : Recent evidence suggests that psychotic-like experiences ( PLEs ) in the general population are important markers of risk of suicidal problems.
BACKGROUND : Recent findings indicate that impairments in functional performance do occur among individuals diagnosed with mild cognitive impairment ( MCI ) .
BACKGROUND : Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells.
BACKGROUND : Recent genomewide association study meta-analyses have identified @number@ loci associated with risk of Parkinson's disease ( PD ) .
BACKGROUND : Recently , corrective fusion surgery for patients with adult spinal deformity ( ASD ) has become common in Japan.
BACKGROUND : Recently , subclinical aspiration has been identified in approximately @percent@ of community-dwelling older adults.
BACKGROUND : Recently , the efficacy of autologous plasma filler for the reduction of facial wrinkles has been demonstrated.
BACKGROUND : Recently , the LIfestyle for BRAin health ( LIBRA ) index was developed to assess an individual's prevention potential for dementia.
BACKGROUND Recently , the use of cardiac implantable electrophysiological devices ( CIEDs ) has increased.
BACKGROUND : Recent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25 , smoking quantity , and lung cancer.
BACKGROUND : Recent observational studies have suggested that the use of beta blockers might be associated with better prognosis after cancer.
BACKGROUND : Recent posttrial analysis of a completed randomized trial found an increased risk of prostate cancer among healthy men taking high-dose vitamin E supplements.
BACKGROUND : Recent research has highlighted the important role of emotion dysregulation in the occurrence and maintenance of depressive symptomatology.
BACKGROUND : Recent research has linked overall dietary patterns to survival in older adults.
BACKGROUND : Recent studies have indicated the predominance of Toxoplasma gondii genotype Chinese @number@ in animals in China.
BACKGROUND : Recent studies have revealed the associations between insulin resistance ( IR ) and geriatric conditions such as frailty and cognitive impairment.
BACKGROUND : Recent studies have shown that vitamin D status may be relevant for physical and cognitive performance in the older population.
BACKGROUND : Recent studies have suggested that a series of low-energy , single-pass ablative laser resurfacing micropeels can reduce photoaging with decreased downtime.
BACKGROUND : Recent studies have suggested that the age-personality relationship may be partly explained by age-related changes in response bias.
BACKGROUND : Recent studies suggest potential associations between childhood adversity and chronic inflammation at older ages.
BACKGROUND : Recent studies suggest that bone and muscle wasting are closely interconnected.
BACKGROUND : Recent studies with younger adults have shown that performance feedback can serve as a reward , and it elicits reward-related brain activations.
BACKGROUND : Recognition of familiar music depends on several levels of processing.
BACKGROUND : Recovery from stroke is presumed to be a function of a widespread cerebral network.
BACKGROUND : Rectal cancer ( RC ) is a common malignancy with a substantial mortality but good survival for patients with optimally treated nonmetastatic disease.
BACKGROUND : Red blood cells collected in can be stored for up to @number@ days at @number@ °C in additive solution.
BACKGROUND : Red meat intake has been associated with risk of colorectal cancer , potentially mediated through heterocyclic amines.
BACKGROUND : Reduced availability of nitric oxide leads to dysfunction of endothelium which plays an important role in the development of cardiovascular diseases.
BACKGROUND : Reduced CBF has been reported in patients with heart failure ( HF ) .
BACKGROUND : Reduced muscular strength in the old age is strongly related to activity impairment and mortality.
BACKGROUND : Reduced P300 event-related potential ( ERP ) amplitude and latency prolongation have been reported in patients with schizophrenia compared to healthy controls.
BACKGROUND : Reduced renal function increases the risk of adverse drug reactions ( ADRs ) to hydrosoluble drugs ( hADRs ) .
BACKGROUND : Reduction of precuneus choline acetyltransferase activity co-occurs with greater beta-amyloid ( Aβ ) in Alzheimer's disease ( AD ) .
Background : Reference ranges for testosterone are essential for making a diagnosis of hypogonadism in men.
BACKGROUND : Reference values and age-related changes of the wall thickness of the abdominal aorta have not been described in the general population.
BACKGROUND : Regular fish and omega-3 consumption may have several health benefits and are recommended by major dietary guidelines.
BACKGROUND : Relationship between respiratory morbidity and influenza virus has been well-documented in infants , whatever their age.
BACKGROUND : Relationships between alcohol consumption and risks for metabolic syndrome in general populations are very controversial.
BACKGROUND : Renal cell carcinoma is among the most prevalent malignancies.
BACKGROUND : Renal function impairment is common in geriatric palliative care patients.
BACKGROUND : Renal impairment is a major risk factor for mortality in various populations.
BACKGROUND : Repeated exposure to ultraviolet ( UV ) rays damages skin connective tissue , which is thought to be associated with wrinkle formation.
BACKGROUND : Repeated rehearsal is one method by which verbal material may be transferred from short- to long-term memory.
BACKGROUND : Repeat treatments of nonpermanent dermal fillers are used in the long-term treatment of wrinkles and folds and to volumize.
BACKGROUND : Reports of subjective sleep quality are frequently collected in research and clinical practice.
BACKGROUND : Reproductive aging resulting in menopause with permanent cessation of ovarian follicular activity.
BACKGROUND : Researchers have been examining the relationship between obesity and hypertension.
BACKGROUND : Researchers have increasingly sought noninvasive methods to determine health and nutritional status in humans.
BACKGROUND : Research has investigated the decrease in human skin sebum after the application of botulinum toxin.
BACKGROUND : Research has recently suggested that retirement may decrease cognitive engagement , resulting in cognitive aging.
BACKGROUND : Research has shown network social capital associated with a range of health behaviours and conditions.
BACKGROUND : Research illustrates cognitive deficits in children and younger adults with attention-deficit / hyperactivity disorder ( ADHD ) .
BACKGROUND : Research indicates that stress is linked to cognitive dysfunction.
BACKGROUND : Research indicates that the so-called baby boomer generation ( the population born after World War II ) exhibits worrying health trends.
BACKGROUND : Research into nursing home transitions has given limited attention to the facility or community contexts.
BACKGROUND : Research on aging has consistently demonstrated an increased chance of survival for older adults who are integrated into rich networks of social relationships.
BACKGROUND : Research on aging has shown a significant decline in ToM after @number@ years of age.
BACKGROUND : Research on cognitive control suggests an age-related decline in proactive control abilities whereas reactive control seems to remain intact.
BACKGROUND : research on the association between habitual sleep duration and quality in older adults is scarce and has shown conflicting results.
BACKGROUND : Research shows that lipid levels may be associated with cognitive function , particularly among women.
BACKGROUND : residential aged care facility ( RACF ) resident numbers are increasing.
BACKGROUND : Resilience has been identified as a personal construct that may contribute to the process of healthy ageing in older people.
BACKGROUND : Resistance exercise increases muscle mass and function in older adults , but responses are attenuated compared with younger people.
BACKGROUND : Resolution is the final stage of the inflammatory response , when restoration of tissue occurs.
BACKGROUND : Resources to help the older aged ( ≥65 year olds ) manage their medicines should probably target those in greatest need.
BACKGROUND : Respect for patient autonomy has been the cornerstone of clinical bioethics for several decades.
BACKGROUND : Respiratory muscle strength is influenced by aging.
BACKGROUND : Respiratory syncytial virus ( RSV ) is the major cause of lower respiratory tract infection in infants.
BACKGROUND : Restoration of cheek volume is recognized as an important part of facial rejuvenation.
BACKGROUND : Restorative home care services are short-term and aimed at maximizing a person's ability to live independently.
BACKGROUND : Results from numerous studies suggest protective effects of the Mediterranean diet for cardiovascular disease , cancer , and mortality.
BACKGROUND : Results of prospective studies examining the association between cystatin C and incident cognitive impairment have been inconsistent.
BACKGROUND : Resveratrol is a key component of red wine that has been reported to have anti-carcinogenic and anti-aging properties.
BACKGROUND : Resveratrol is a plant-derived polyphenol with purported protecting action on various disorders associated with aging.
BACKGROUND : Retinaldehyde ( RAL ) was proven effective in treating photodamaged skin.
BACKGROUND : Retinal microvascular signs may provide insights into the structure and function of small vessels that are associated with renal disease.
BACKGROUND : Retinol is used to reduce symptoms of skin aging.
BACKGROUND : Retirement is a major life transition affecting health behaviors.
BACKGROUND : Return to productive employment is often an important milestone in the recovery and rehabilitation process after liver transplantation ( OLT ) .
BACKGROUND : Rheumatic diseases , irrespective of etiology and clinical course , influence different areas of a patient's life.
BACKGROUND : Rhinitis is one of the most frequent medical conditions.
BACKGROUND : Rhinoviruses ( RV ) are key triggers in acute asthma exacerbations.
BACKGROUND : Ribonuclease-L ( RNase-L ) was known to be a ubiquitous enzyme involved in several cellular functions , especially innate immunity.
BACKGROUND : Risk factors for late-life depression have been studied in high-income countries , but there have been no longitudinal studies from middle-income countries.
BACKGROUND : Rodent studies show that neurogenesis is necessary for mediating the salutary effects of antidepressants.
BACKGROUND : Romania has some of the highest mortality figures in the world attributable to ischemic heart disease and stroke among both men and women.
BACKGROUND : Romosozumab , a monoclonal antibody that binds sclerostin , increases bone formation and decreases bone resorption.
BACKGROUND : RT002 is a new injectable BoNTA product.
BACKGROUND : Same day discharge after PCI is becoming more and more appealing and patient's selection criteria are being formulated.
BACKGROUND : Sandhoff disease is a lysosomal storage disorder characterized by the absence of β-hexosaminidase and storage of GM2 ganglioside and related glycolipids.
Background : Sarcopenia affects more than @percent@ of older adults.
BACKGROUND : Sarcopenia , a gradual loss of muscle mass and function , has been associated with poor health outcomes.
BACKGROUND : Sarcopenia describes the age-associated loss of muscle mass , strength and function.
BACKGROUND : Sarcopenia has been accepted as a new geriatric syndrome , which will become a common and important public health challenge.
BACKGROUND : Sarcopenia is a multifactorial geriatric syndrome with complex interrelationships.
BACKGROUND : Sarcopenia is commonly defined as loss of muscle mass with limited muscle function or strength.
BACKGROUND : Sarcopenia is the progressive loss of mass and skeletal muscle strength and has serious consequences on older people's health.
BACKGROUND : Sarcopenia , the decrease in muscle mass and function , may lead to various negative health outcomes in elderly.
BACKGROUND : Sarcopenia , the loss of muscle mass and function with age , is associated with increased morbidity and mortality.
BACKGROUND : Sarcopenia , the loss of muscle mass and strength , is associated adversely with disability , morbidity and mortality.
BACKGROUND : Sarcopenic obesity ( SO ) is a geriatric syndrome characterized by the disproportion between the amount of lean mass and fat mass.
BACKGROUND : Scalp psoriasis is a chronic recalcitrant condition.
BACKGROUND : Schizophrenia is linked with early medical comorbidity and mortality.
BACKGROUND : Schizophrenia ( SCZ ) and bipolar disorder ( BD ) share some cognitive commonalities.
BACKGROUND : Screening for frailty might help to prevent adverse outcomes in hospitalised older adults.
BACKGROUND : SDD has been shown to be safe after elective , low-risk PCI.
BACKGROUNDS : Different and new approaches have been proposed to prevent the risk of falling of elderly people , particularly women.
BACKGROUND : Seafaring is known to be a demanding occupation but the implications of ageing in seafarers are poorly understood.
BACKGROUND : Secondary hyperparathyroidism in elderly fragile patients presents clinical difficulties due to severity of symptoms and related comorbidity.
BACKGROUND : Secondary mitral regurgitation is characterized by cardiomyopathy , mitral annular enlargement , and leaflet traction contributing to malcoaptation.
BACKGROUND : Secondhand smoke ( SHS ) likely provides additional exposure to nicotine and toxins for smokers , but has been understudied.
BACKGROUND : Sedentary behavior is associated with adverse health effects.
BACKGROUND : Sedentary behaviour and its association with dietary intake in young people and adults are important topics and were systematically reviewed in @number@
BACKGROUND : Sedentary lifestyle combined with smoking , contributes to the development of a set of chronic diseases and to accelerating the course of aging.
BACKGROUND : Sedentary time is increasing in all societies and results in limited non-exercise physical activity ( NEPA ) of daily life.
BACKGROUND : Self-care disability is dependence on others to conduct activities of daily living , such as bathing , eating and dressing.
Background : Self-neglect and suicidal ideations are important public health issues among the aging population.
BACKGROUND : Self-perceived uselessness is associated with poor health and high mortality among older adults in China.
BACKGROUND : Self-perception of uselessness is associated with increased mortality risk in older adults.
BACKGROUND : self-rated health ( SRH ) predicts nursing home ( NH ) placement ; subjective memory complaints ( SMC ) too.
BACKGROUND : Self-reported health is a widely used measure of health status across individuals.
BACKGROUND : Senescent endothelial cells acquire functional properties that make the vascular wall more prone to atherosclerotic changes.
BACKGROUND : Senile entropion is a common pathology of the aging lid.
BACKGROUND : Senile plaques in Alzheimer's disease ( AD ) are composed of amyloid-β ( Aβ ) , especially N-truncated forms including Aβ4-42.
BACKGROUND : Seniors constitute the largest group of hospital users.
BACKGROUND : Sense of self-worth influences the health status of the elderly and may be associated with mortality.
BACKGROUND : Sensitive skin represents hyperactive sensory symptoms showing exaggerated reactions in response to internal stimulants or external irritants.
BACKGROUND : Serial chest CT is the standard of care to establish treatment success in invasive pulmonary aspergillosis ( IPA ) .
BACKGROUND : Serum alanine aminotransferase ( ALT ) is a marker of liver injury.
BACKGROUND : Serum AMH is declining with age and is highly associated with ovarian follicular reserve and disordered folliculogenesis.
BACKGROUND : Serum amino acids , part of a pool of free amino acids , are influenced by metabolism and disease.
BACKGROUND : Serum levels of zinc and copper have been proposed to associate with sleep duration.
BACKGROUND : Serum pre-adipocyte factor-1 ( pref-1 ) is an inhibitor of adipocyte differentiation that increases in small for gestational age fetuses.
BACKGROUND : Serum vitamin D levels have been reported to be associated with individual components of body composition.
BACKGROUND : Several blood biomarkers have been linked to functional disability , a health problem in general populations.
BACKGROUND : Several epidemiological studies have demonstrated associations between variability in a number of biological parameters and adverse outcomes.
BACKGROUND : Several laser technologies exist for improving rhytides , pigmentation , and skin texture.
BACKGROUND : Several lines of evidence suggest that the multisystem disease seen in drug addicts may reflect acceleration of underlying degenerative or ageing processes.
BACKGROUND : Several measures of medication exposure are associated with adverse outcomes in older people.
BACKGROUND : Several previous studies have reported an undertreatment of pain in elderly persons with dementia.
BACKGROUND : Several studies demonstrate that estrogen treatment improves cerebral blood flow in ischemic brain regions of young ovariectomized ( OVX ) rats.
BACKGROUND : several studies have been pointing towards a non-linear relationship between serum 25 ( OH ) D and cardiovascular disease.
BACKGROUND : Several studies have confirmed dramatic changes in skin surface parameters during the winter months.
BACKGROUND : Several studies have investigated the interaction between motivation and cognition in both young and older adults , but with inconsistent results.
BACKGROUND : Several studies have reported an age-related decline of physical activity ( PA ) .
BACKGROUND : Several studies have reported smaller hippocampal volume ( HcV ) in depression patients ; however , the temporality of the association remains unknown.
BACKGROUND : Several studies have reported that height is inversely associated with risk of cardiovascular disease but positively associated with cancer risk.
BACKGROUND : Several studies have reported the influence of diverse winemaking technologies in white wine characteristics.
BACKGROUND : Several studies reported on the association of type @number@ diabetes ( T2DM ) with dementia.
BACKGROUND : several studies suggest that a decreased thyroid activity might be favourable in oldest-old subjects and that subclinical thyroid hyperfunction may be detrimental.
BACKGROUND : Severe aortic stenosis ( AS ) is now predominantly a disease of the elderly , with significant mortality and morbidity.
BACKGROUND : Sex and age strongly influence the pathophysiology of human lungs , but scarce information is available about their effects on pulmonary gene expression.
BACKGROUND : Sex hormones and adipokines seem to differently interact in both genders at different ages.
BACKGROUND : Sex-specific trajectories in white matter development during adolescence may help explain cognitive and behavioral divergences between males and females.
BACKGROUND : Sexuality has become a medical issue in association with aging.
BACKGROUND : Sexuality is a significant component in human experience and has an important impact on the individual's general well-being.
BACKGROUND : Shift work is associated with sleep and health problems.
BACKGROUND : Short sleep duration has been associated with greater risks of obesity , hypertension , diabetes , and cardiovascular disease.
BACKGROUND : SIAscopy ( Spectrophotometric Intracutaneous Analysis ) enables non-invasive analysis of the skin.
BACKGROUND : Significant changes in scalp , facial and body hair occur after the menopause.
BACKGROUND : Significantly increased cardiovascular mortality in patients with chronic kidney ( CKD ) disease cannot be explained by traditional risk factors.
BACKGROUND : Similarities between mice and humans lead to generation of many mouse models of human disease.
BACKGROUND : Since @number@ more than @number@ @number@ refugees and displaced persons , survivors of conflicts in over @number@ countries , have resettled in Australia.
BACKGROUND : Since the late @number@'s , a steadily increasing immigrant population in Germany is resulting in a subpopulation of aging immigrants.
BACKGROUNDS : In non-critical hospitalized patients with diabetes mellitus , guidelines suggest subcutaneous insulin therapy with basal-bolus regimen , even in old and vulnerable inpatients.
BACKGROUND : Sino-atrial node disease and aging increase AF risk.
BACKGROUND : sip feeds are oral nutritional supplements ( ONSs ) that are commonly prescribed to malnourished patients to improve their nutritional and clinical status.
BACKGROUND : SIRT1 , which belongs to the Sirtuin family of NAD-dependent enzymes , plays diverse roles in aging , metabolism , and disease biology.
BACKGROUND : Sit-to-stand ( STS ) movement is useful for evaluating lower limb muscle function , especially from force platforms.
Background : Skeletal muscle insulin resistance and reduced mitochondrial capacity have both been reported to be affected by aging.
BACKGROUND : Skeletal muscle ( SM ) mass decreases with advanced age and with disease in HIV infection.
BACKGROUND : Skill-related fitness ( SRF ) is a component of physical fitness related to sports or occupational performance.
BACKGROUND : Skin aging is a multifactorial phenomenon which causes alterations in skin physiological functions and , most visibly , phenotypic changes.
BACKGROUND : Skin changes caused by aging increase the risk of skin damages , such as pressure ulcers , during hospitalization of elderly patients.
BACKGROUND : Skin maceration is recognized as a risk factor for the development of certain skin lesions.
BACKGROUND : Sleep and melatonin have been associated with healthy aging.
BACKGROUND : Sleep complaints are prevalent in older patients.
BACKGROUND : Sleep disorders causes a significant negative effect on mental and physical health , particularly among the elderly.
BACKGROUND : Sleep disturbance and cognitive impairment are correlated in non-diseased populations , but their association in Parkinson's disease ( PD ) is uncertain.
BACKGROUND : Sleep disturbance in midlife women has been studied extensively , although less is known about sleep after menopause.
BACKGROUND : Sleep disturbance is a common complaint in the general population.
BACKGROUND : Sleep disturbance is a common complaint of patients with a rotator cuff tear.
BACKGROUND : Sleep disturbance is associated with activation of systemic and cellular inflammation , as well as proinflammatory transcriptional profiles in circulating leukocytes.
BACKGROUND : Sleep disturbance is suggested to contribute to the development of dementia.
BACKGROUND : Sleep disturbances are common in patients with chronic lung diseases , but little is known about the prevalence in patients with bronchiectasis.
BACKGROUND : Sleep is crucial for cognition , particularly for memory , given its complex association with neurodegenerative processes.
BACKGROUND : Sleep plays a pivotal role in normal biological functions.
BACKGROUND : Slowed gait is an important health indicator in older adults but a single identifiable cause is often lacking.
BACKGROUND : Slow walking with reduced body dynamics is a characteristic feature of locomotion in the elderly.
BACKGROUND : Smart home technologies provide a valuable resource to unobtrusively monitor health and wellness within an older adult population.
BACKGROUND : Smoking is a major cause of morbidity and mortality.
BACKGROUND : Social capital is an economical idea that refers to connections between individuals and entities that can be economically valuable.
BACKGROUND : Social engagement and depression are important outcomes for residents with dementia in long-term care.
BACKGROUND : Social isolation may operate as a psychosocial stressor which disrupts functioning of the axis.
BACKGROUND : Social network research has become central to studies of health and aging.
BACKGROUND : Social relationships are important at all stages of life.
BACKGROUND : socioeconomic inequalities in mortality are well-known in middle-aged and younger old adults , but the situation of the oldest old is less clear.
BACKGROUND : Socioeconomic inequalities in mortality can be explained by different groups of risk factors.
BACKGROUND : Socioeconomic inequalities in obesity are consistently observed in high-income countries.
BACKGROUND : Socio-economic status has been associated with diabetes in cross-sectional studies.
BACKGROUND : Soft tissue augmentation is increasingly being performed to treat male facial aging.
BACKGROUND : Soil-transmitted helminth ( STH ) infection peaks during childhood and varies by sex.
BACKGROUND : Somatostatin ( SST ) has anti-proliferative and pro-apoptotic effects.
BACKGROUND : Some effects of the red blood cell ( RBC ) storage lesion are well documented whereas others are not.
BACKGROUND : Some executive functions may be selectively impaired in normal aging over and above the general cognitive decline.
BACKGROUND : Some practitioners have criticized the unpredictable retention associated with autologous fat transfer.
BACKGROUND : Some premature features of immunosenescence have been associated with persistent viral infections and altered populations of T cells.
BACKGROUND : Some studies have reported that overall diet quality affects bone status in postmenopausal women ; however , the findings are inconsistent.
BACKGROUND : Sometimes it might not be possible to conduct a pharmacokinetic ( PK ) study in neonates and infants.
BACKGROUND : Spanish is the second-most common language spoken in the United States , and Spanish speakers represent one third of the aging population.
BACKGROUND : Spastic limb paralysis due to injury to a cerebral hemisphere can cause long-term disability.
BACKGROUND : Specific mechanisms behind the role of oxidative / nitrosative stress and mitochondrial dysfunction in Alzheimer's disease ( AD ) pathogenesis remain elusive.
BACKGROUND : Spermidine , a naturally occurring polyamine , has recently emerged as exhibiting anti-aging properties.
BACKGROUND : Spinal cord injury ( SCI ) has a negative impact on quality of life and healthcare costs.
BACKGROUND : Sports-associated sudden cardiac arrests ( SCAs ) occur mostly during middle age.
BACKGROUNDS : Selenium ( Se ) as one of the essential trace elements for human plays an important role in the oxidation reduction system.
BACKGROUND : Stair climbing is an important but neglected aspect of independent living.
BACKGROUND : Stair descent is a frequent daily activity that poses great risks for injury due to falling.
BACKGROUND : Standing balance is imperative for mobility and avoiding falls.
BACKGROUND : State dental boards maintain minimal demographic and practice characteristics about licensed dentists.
BACKGROUND : Statins are used to lower cholesterol in plasma and are one of the most used drugs in the world.
BACKGROUND : Statin use and serum cholesterol reduction have been proposed as preventions for dementia and mild cognitive impairment ( MCI ) .
BACKGROUND : Statistical models of normal ageing brain tissue volumes may support earlier diagnosis of increasingly common , yet still fatal , neurodegenerative diseases.
BACKGROUND : Stem cell therapies are advertised through online resources which describe a range of treatments with diverse clinical indications.
BACKGROUNDS : The dermatologic diseases of the dependent elderly require special attention.
BACKGROUND : Stomach cancer is one of the leading causes of cancer deaths in Japan.
BACKGROUND : Strategies to improve influenza vaccine protection among elderly individuals are an important research priority.
BACKGROUND : Straw drinking is often recommended as a strategy for managing swallowing difficulties in adult clinical populations.
BACKGROUND : Streptococcus pneumoniae infection is the most common cause of community-acquired pneumonia in adults.
BACKGROUND : Stress affects health-related quality of life through several pathways , including physiological processes and health behaviors.
BACKGROUND : Stroke and low heart rate variability ( HRV ) are both associated with an unfavorable prognosis in hemodialysis patients.
BACKGROUND : Stroke is a common and important adverse event after acute myocardial infarction ( AMI ) in the elderly.
BACKGROUND : Stroke is a leading cause of death and disability in South Africa.
BACKGROUND : Stroke is a leading cause of mortality with a major effect on health-related quality of life ( HRQoL ) .
BACKGROUND : Stroke is associated with an increased risk of dementia.
BACKGROUND : Stroke survivors represent a target population in need of intervention strategies to promote cognitive function and prevent dementia.
BACKGROUND : Stroke survivors ' risk of falls may be particularly sensitive to the environment due to deficits such as visuospatial neglect or homonymous hemianopia.
BACKGROUND : Strong evidence implicates inflammation in the development of atherosclerotic heart disease but less is known about peripheral arterial disease ( PAD ) .
BACKGROUND : Structural changes occur in the pancreas as a part of the natural aging process.
BACKGROUND : Structure and function of the human brain are subjected to dramatic changes during its development and aging.
BACKGROUND : ST-segment elevation in a structurally normal heart is observed in Brugada- and early repolarization syndrome.
BACKGROUND : Studies have shown that inadequate access to healthcare is associated with lower levels of health and well-being in older adults.
BACKGROUND : Studies have shown that oxidative stress increases with increasing human age.
BACKGROUND : Studies in male combat veterans have suggested posttraumatic stress disorder ( PTSD ) is associated with shorter telomere length ( TL ) .
BACKGROUND : Studies investigating the association between hypercholesterolemia in the elderly and cognitive decline report discrepant outcomes.
BACKGROUND : Studies linking low serum testosterone concentration to adverse clinical outcomes in hemodialysis patients have been relatively small.
BACKGROUND : Studies of cancer pain management in older people are lacking and more information is needed.
BACKGROUND : Studies of hypertension and cognition variously report adverse , null , and protective associations.
BACKGROUND : Studies on life-space ( LS ) and its determinants have previously been limited to community-dwelling subjects but are lacking in institutionalized older persons.
BACKGROUND : Studies on the relationship between testosterone concentrations and blood pressure have yielded inconsistent results.
BACKGROUND : Studies show that exposure to air pollution damages human health , but the mechanisms are not fully understood.
BACKGROUND : Studies suggest a higher prevalence of early retirement through disability among older people with lower educational attainment.
BACKGROUND : Studies suggest an association between weight change and subsequent poor physical health functioning , whereas the association with mental health functioning is inconsistent.
BACKGROUND : Subarachnoid hemorrhage ( SAH ) from a ruptured intracranial aneurysm is a devastating disease with high mortality and morbidity.
BACKGROUND : Subclinical cerebrovascular disease has been associated with multiple adverse events related to aging , including stroke and dementia.
BACKGROUND : Subclinical hyperthyroidism ( SHyper ) has been associated with increased risk of hip and other fractures , but the linking mechanisms remain unclear.
BACKGROUND : Subcortical ischemic vascular dementia ( SIVD ) represents an important subgroup of vascular dementia.
BACKGROUND : Subjective memory impairment ( SMI ) refers to conditions in which people complain of memory problems despite intact cognition.
BACKGROUND : Subjective reports of insomnia and hypersomnia are common in bipolar disorder ( BD ) .
BACKGROUND : Suicidal ideation is a public health issue that has a significant impact at the individual , family , community , and societal levels.
BACKGROUND : Suicidal ideation is more strongly associated with suicidal intent in later life , so risk factors may also differ by age.
BACKGROUND : Suicidal ideation ( SI ) and attempts are increased in Huntington's disease ( HD ) , making risk factor assessment a priority.
BACKGROUND : Suicide rates are highest among the elderly , yet research on suicide prevention in old age remains a much-neglected area.
BACKGROUND : Sun exposure is an important environmental factor affecting human beings.
BACKGROUND : Survivors of pediatric acute lymphoblastic leukemia ( ALL ) have a significantly higher body mass index ( BMI ) than their peers.
BACKGROUND : Sustained remodeling of extracellular matrix can compromise organs and tissues.
BACKGROUND : Symptoms of hazelnut allergy seem related to geographic and possibly age variations in allergen recognition.
BACKGROUND : Systematic review evidence has shown that step training reduces the number of falls in older people by half.
BACKGROUND : systemic arterial hypertension is the most prevalent cardiovascular disease ; physical activity for hypertensive patients is related to several beneficial cardiovascular adaptations.
BACKGROUND : Systems biological approach of molecular connectivity map has reached to a great interest to understand the gene functional similarities between the diseases.
BACKGROUND : Systolic blood pressure and pulse pressure are substantially higher in older adults.
BACKGROUND : Taking into account our rapidly ageing population , older people are of particular interest in studying health inequalities.
Background : Task modification refers to performing a task differently than before.
BACKGROUND : Technological advances are leading to the ability to autonomously monitor patient's health status in their own homes , to enable aging-in-place.
BACKGROUND : Technology plays a major role in enhancing quality of life and everyday competence in old age.
BACKGROUND : Telomerase is a ribonucleoprotein enzyme capable of extending chromosome ends with telomeric DNA sequences.
BACKGROUND : Telomere attrition is extremely rapid during the first years of life , while lifestyle during adulthood exerts a minor impact.
BACKGROUND : Telomere length and telomere shortening are associated with age-related health outcomes.
BACKGROUND : Telomere length predicts cardiovascular disease ( CVD ) possibly through an impact of telomere attrition on aortic stiffness.
BACKGROUND : Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease ( CVD ) .
BACKGROUND : Telomeres are complex structures formed by the end of the DNA molecule at the tip of chromosomal arms.
BACKGROUND : Telomeres are DNA-protein complexes that cap chromosomal ends , promoting chromosome stability.
BACKGROUND : Telomeres are non-coding regions of DNA that cap the ends of chromosomes.
BACKGROUND : Telomeres are repetitive DNA sequences located at the ends of chromosomes , and telomere length represents a biological marker for cellular aging.
BACKGROUND : Telomeres are repetitive , gene-poor regions that cap the ends of DNA and help maintain chromosomal integrity.
BACKGROUND : Telomeres are tandem repeats of sequences present at the end of the chromosomes that maintain chromosomal integrity.
BACKGROUND : Telomeres can be considered a marker of biological aging.
BACKGROUND : Telomere shortening and alterations of mitochondrial biogenesis are involved in cellular aging.
BACKGROUND : Telomeres shorten as cells divide.
BACKGROUND : Temporal lobe epilepsy ( TLE ) is often characterized pathologically by severe neuronal loss in the hippocampus.
BACKGROUND : Temporal processing ability has been linked to speech understanding ability and older adults often complain of difficulty understanding speech in difficult listening situations.
BACKGROUND : Tendon insertion pathologies such as enthesitis and apophysitis in children can result from trauma , overuse syndrome and arthritis.
BACKGROUND : Testing whether familial socioeconomic status ( SES ) in childhood is a predictor of mortality has rarely been done on historical cohorts.
BACKGROUND : Testosterone replacement therapy ( TRT ) is a widely accepted form of treatment worldwide for aging men with late-onset hypogonadism syndrome.
BACKGROUND : Tetracycline-containing triple therapy has been suggested as an alternative first-line therapy for H. pylori infection.
BACKGROUND : Tetralogy of Fallot ( TOF ) is a common cyanotic congenital heart disease with increasingly recognized late morbidity.
BACKGROUND : Texture within biological specimens may reveal critical insights , while being very difficult to quantify.
BACKGROUND : The ability of inflammatory markers to predict disability in later life has received growing attention.
BACKGROUND : The ability of older people to function independently is crucial as physical disability and functional limitation have profound impacts on health.
BACKGROUND : The ability of the Sensory Organization Test ( SOT ) to detect subtle balance problems has been challenged.
BACKGROUND : The ability to measure surgical quality of care is important and can lead to improvements in patient safety.
BACKGROUND The abnormal activity of Sirtuin @number@ ( Sirt1 ) is closely related to the aging of vascular endothelial cells.
BACKGROUND : The activity patterns of older adults include more light / mild-intensity or \ "non-exercise \ " activity and less moderate- to vigorous-intensity activity.
BACKGROUND : The adenoma detection rate ( ADR ) is an important surrogate measure of performance quality for screening colonoscopies.
BACKGROUND : The AD etiology is yet not properly known.
BACKGROUND : The aetiology of Alzheimer's disease ( AD ) is believed to involve environmental exposure and genetic susceptibility.
BACKGROUND : The Affordable Care Act ( ACA ) required most insurers and the Medicare program to eliminate cost sharing for screening mammography.
BACKGROUND : The African , Caribbean and Black communities have been found to be reluctant to participate in health research in North America.
BACKGROUND : The age- and sex-associated changes of brain development are unclear and controversial.
BACKGROUND : the ageing demographic means that increasing numbers of older people will be attending emergency departments ( EDs ) .
BACKGROUND : The ageing of the population is poised to emerge as a preeminent worldwide phenomenon.
BACKGROUND : The ageing of the worldwide population means there is a growing need for research on the biology of ageing.
BACKGROUND : The ageing process transforms the histological composition of the dental pulp and may affect the response to pulp sensibility tests.
BACKGROUND : The aging of the nursing workforce is a phenomenon that several industrialized countries has been facing for at least a decade.
BACKGROUND : The aging of the population will make fecal incontinence an increasingly important socioeconomic problem in the coming decades.
BACKGROUND : The aging of the workforce poses new challenges for maintaining work ability.
BACKGROUND : The aging of Western populations is expected to result in increasing occurrence of aortic stenosis ( AS ) , but data are limited.
BACKGROUND : The aging population and increasing obesity rates will increase the prevalence of musculoskeletal conditions.
BACKGROUND : The aging population and lack of gerontological preparation in pre-licensure nursing programs are pressing issues.
BACKGROUND : The aging population in prison is growing rapidly in the United Kingdom.
BACKGROUND : The aging population is a globally recognized challenge for the health care service.
BACKGROUND : The aging process affects the skin , muscle , and fat of the eyes in a different manner.
BACKGROUND : The aging process is accompanied by physiological changes including reduced glomerular filtration and hepatic function , as well as changes in gastric secretions.
BACKGROUND : The aging process is associated with the development of several diseases , which can be attenuated by the practice of physical activities.
BACKGROUND : The aging process is often associated with the presence of sarcopenia.
BACKGROUND : The aim of the study was to determine which risk factors were associated with the recurrence of falls among community-dwelling older adults.
BACKGROUND : The aim of the study was to verify the association between body composition and physical fitness with bone status in children and adolescents.
BACKGROUND : The aim of this study is to report the 6-year incidence of age-related cataract in a population-based study.
BACKGROUND : The aim of this study was to determine whether eyebrow and eyelash whitening is an effective parameter in age estimation.
BACKGROUND : The alarming prevalence of heart failure with preserved ejection fraction requires quantification of diastolic dysfunction ( DDF ) .
BACKGROUND : The American Heart Association recently defined cardiovascular health ( CVH ) to monitor it over time for all Americans.
BACKGROUND : The American Institute of Architects recommends that private rooms become the industry standard for all new construction of acute care hospitals.
BACKGROUND : The analysis of DNA methylation is a key component in the development of personalized treatment approaches.
BACKGROUND : The anatomy of the substantia nigra on conventional MRI is controversial.
BACKGROUND : The antioxidant melatonin effectively scavenges highly toxic hydroxyl radicals.
BACKGROUND : The apolipoprotein E ( APOE ) ε4 allele and stroke increase the risk of cognitive decline.
BACKGROUND : The apolipoprotein E ( APOE ) ε4 genotype is associated with an increased risk of Alzheimer's disease.
BACKGROUND : The apolipoprotein E ɛ4 ( APOE4 ) allele is the strongest genetic risk factor identified for developing Alzheimer's disease ( AD ) .
BACKGROUND : The article discusses the position of elderly patients in medical intervention context.
BACKGROUND : The assessment and management of dementia is complex.
BACKGROUND : The assessment of mobility is essential to both aging research and clinical geriatric practice.
BACKGROUND : The assessment of the appropriate level of development in children belongs to the standard duties of physicians in the public health system.
BACKGROUND : The association of age-related cognitive change with hospitalization is not well understood.
BACKGROUND : The association of genetic polymorphisms of klotho gene with aging has not been thoroughly examined.
BACKGROUND : The association of red blood cell ( RBC ) storage on morbidity outcome after cardiac surgery is debated.
BACKGROUND : The asymptomatic carriers of the Leucine rich repeat kinase @number@ ( LRRK2 ) G2019S mutation represent a population at risk for developing PD.
BACKGROUND : The authors evaluated their experience with facial rejuvenation in the massive weight loss patient.
BACKGROUND : The autosomal dominant spinocerebellar ataxias are most commonly caused by nucleotide repeat expansions followed by base-pair changes in functionally important genes.
BACKGROUND : The avalanche of integromics and panomics approaches shifted the deciphering of aging mechanisms from single molecular entities to communities of them.
BACKGROUND : The baby boomer population will become high users of the health-care system in coming years.
BACKGROUND : The barrier perturbation pattern and molecular markers of inflammation upon tandem repeated irritation in chronologically aged skin have not been previously studied.
BACKGROUND : The beneficial effects of testosterone treatment ( TT ) are debated.
BACKGROUND : The benefits and risks of long-term testosterone administration have been a topic of much scientific and regulatory interest in recent years.
BACKGROUND : The burden of chronic disease continues to rise as populations age.
BACKGROUND : The burden of subclinical atherosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developing clinical coronary heart disease.
BACKGROUND : The C677T polymorphism of the methylenetetrahydrofolate reductase ( MTHFR ) has been associated with acute lymphoblastic leukemia ( ALL ) .
BACKGROUND : The CALIPER program has previously reported a comprehensive database of pediatric reference intervals for @number@ biochemical and immunochemical markers.
BACKGROUND : The carbon dioxide laser ( CO2 ) has been proven to be an effective device for the treatment of photoaging.
Background : The cause-effect relationship between bilateral oophorectomy and accelerated aging remains controversial.
BACKGROUND : The causes of increased risk of sudden cardiac death in schizophrenia are not resolved.
BACKGROUND : The cerebellum plays an important role in mobility and cognition.
BACKGROUND : The challenge of immune senescence has never been addressed in elderly cancer patients.
BACKGROUND : The change in volume of anatomic structures is as a sensitive indicator of Alzheimer disease ( AD ) progression.
BACKGROUND : The choice of the best conduit for root / ascending disease and its impact on longevity remain controversial in quinquagenarians.
BACKGROUND : The cholinergic hypothesis is well established and has led to the development of pharmacological treatments for Alzheimer's disease ( AD ) .
BACKGROUND : The classification of rhinitis in adults is missing in epidemiological studies.
BACKGROUND : The clinical utility of identifying pediatric metabolic syndrome ( MetS ) is controversial.
BACKGROUND : The columella serves as the medial limb of the nasal tripod , with the medial crura functioning as the cartilaginous framework.
BACKGROUND : The complexity of medication therapy in older adults with multiple comorbidities often leads to inappropriate prescribing.
BACKGROUND : The concept of antioxidant therapies assumes high importance as oxidative stress is associated with cardiovascular aging via endothelial dysfunction.
BACKGROUND : The concurrence of intracranial aneurysms and acromegaly has been reported and debated previously.
BACKGROUND : The congenital heart disease population is aging.
BACKGROUND : The continuing care retirement community ( CCRC ) is a long term care alternative available to older adults who are independent upon entrance.
BACKGROUND : The contribution of carotid atherosclerosis to incident dementia remains unclear.
BACKGROUND : The contribution of immune activation to accelerated HIV-disease progression in older individuals has not been delineated.
BACKGROUND : the costs of delivering health and social care services are rising as the population ages and more people live with chronic diseases.
BACKGROUND : The cross-sectional association between impaired glucose / diabetes and depression is inconsistent.
BACKGROUND : The cross talk between RAGE and angiotensin II ( AngII ) activation may be important in the development of atherosclerosis.
BACKGROUND : The CURB-65 score was designed to predict 30-day mortality and decide the site of care of pneumonia.
BACKGROUND : The current demographic transition will lead to increasing demands on health services.
BACKGROUND : The current diagnosis-oriented approach of dizziness does not suit older patients.
BACKGROUND : The Czech Republic ranks among the countries with the highest cancer burden in Europe as well as worldwide.
BACKGROUND : The decision to commit suicide may be impulsive , but lethal suicidal acts often involve planning and forethought.
BACKGROUND : The decrease in firmness is a hallmark of skin aging.
BACKGROUND : The degree to which genetic or environmental factors are associated with early kidney damage among African Americans ( AAs ) is unknown.
BACKGROUND : The demand for health professionals continues to increase , partially due to the aging population and the high proportion of practitioners nearing retirement.
BACKGROUND : The demographic structure of a country changes dramatically with increasing trends toward general population aging and declining birth rates.
BACKGROUND : The detection of incipient functional decline in elderly persons is not an easy task.
BACKGROUND : The detection of left ventricular hypertrophy ( LVH ) is still a common objective of electrocardiography ( ECG ) in clinical practice.
BACKGROUND : The determination of factors affecting curve flexibility is important in idiopathic scoliosis patients with regard to the Risser sign.
BACKGROUND : The developing fetus and pregnant woman can be exposed to a variety of environmental chemicals that may adversely affect their health.
BACKGROUND : The development of effective nutritional strategies in support of muscle growth for patients with chronic obstructive pulmonary disease ( COPD ) remains challenging.
BACKGROUND : The diagnosis of obstructive lung disease ( OLD ) based on clinical grounds is challenging.
BACKGROUND : The diagnosis of osteoporosis in men remains controversial.
BACKGROUND : The diagnosis of thyroid nodular diseases requires an integrated approach that has been widely established over the past years.
BACKGROUND : The discharge process has well-known deficiencies and is therefore a challenging issue requiring improvement in many countries.
BACKGROUND : The DNA methylation-based ' epigenetic clock ' correlates strongly with chronological age , but it is currently unclear what drives individual differences.
BACKGROUND : The early stages of a systematic review set the scope and expectations.
BACKGROUND : The effectiveness of late-life depression treatment can be improved by tailoring interventions to patients ' needs.
BACKGROUND : The effect of the grab bar on dynamic stability when elderly people enter the bathtub remains unclear.
BACKGROUND : The effects of bed rest on the dysregulation of fatty acid and glucose metabolism have not been addressed in the older population.
BACKGROUND : The effects of birth cohorts reflect the historical differences in physical and social environments.
BACKGROUND : The effects of intervention programs on health-related quality of life ( HRQOL ) of patients with hip fracture have not been well studied.
BACKGROUND : - The elderly population faces many difficulties as a result of the aging process.
BACKGROUND : The enthesis , which attaches the tendon to the bone , naturally disappears with aging , thus limiting joint mobility.
BACKGROUND : The epidemiology of chronic pain with advancing age remains poorly established.
BACKGROUND : The epidemiology of cough in the elderly population has not been studied comprehensively.
BACKGROUND : The epidemiology of pain during the last years of life has not been well described.
BACKGROUND : The estimated life expectancy of older persons is an important component of medical decision-making.
BACKGROUND : The etiology of male breast cancer is poorly understood , partly because of its relative rarity.
BACKGROUND : The etiology of male breast cancer is poorly understood , partly due to its relative rarity.
BACKGROUND : The EuroQoL-5D ( EQ-5D ) is a brief , multi-attribute , preference-based health status measurement.
BACKGROUND : The evaluation and treatment of heel pressure injuries are a significant and expensive sequela of the aging population.
BACKGROUND : The evaluation of less frequent genetic variants and their effect on complex disease pose new challenges for genomic research.
BACKGROUND : The evidence suggesting that gait speed may represent a sensitive marker for cognitive decline in the elderly requires support from diverse racial groups.
BACKGROUND : The eyebrow is one of the most important structures of the face from an aesthetic point of view.
BACKGROUND : The eye lens is composed of fiber cells that are filled with α- , β- and γ-crystallins.
BACKGROUND : The eyes are particularly important aesthetic features of the face and revitalization of the infraorbital region has become a focus of aesthetic treatments.
BACKGROUND : The factorial survey ( FS ) method is increasingly used in the social sciences.
BACKGROUND : The factors influencing successful aging ( SA ) are of great interest in an aging society.
BACKGROUND : The factors influencing total plasma homocysteine levels ( tHcy ) are of special interest in the attempt to reduce cardiovascular risk.
BACKGROUND : The failure to provide timely acute illness care can lead to adverse consequences or emergency department ( ED ) use.
Background The fastest growing segment of the population is those age ≥80 who have the highest stroke incidence.
BACKGROUND : The fatty tissue of the face is divided into compartments.
BACKGROUND : The first generation of immigrants to Belgium from Turkey and Northwest Africa are aging and at risk for developing cancer.
BACKGROUND : The frailty syndrome is as a well-established condition of risk for disability.
BACKGROUND : The frontal bone is an anatomical structure of the skull separated by the metopic suture in the childhood.
BACKGROUND : The gait of a healthy person is believed to be more regular and symmetrical than those of an individual with a disease.
BACKGROUND : The generation of hip torques from the hip musculature is an important aspect of the golf swing.
BACKGROUND : The genetic cause of amyotrophic lateral sclerosis ( ALS ) is not well understood.
BACKGROUND : The global trend of increased life expectancy and increased prevalence of chronic and degenerative diseases will impact on health systems.
Background The gluteus medius ( GMed ) and gluteus minimus ( GMin ) provide dynamic stability of the hip joint and pelvis.
BACKGROUND : The growing older adult population and shortage of health professionals with adequate knowledge of their specialized needs will strain the health care system.
BACKGROUND : The growing trend for women to postpone childbearing has resulted in a dramatic increase in the incidence of trisomic pregnancies.
BACKGROUND : The gustatory system plays a critical role in determining food preferences , food intake and energy balance.
BACKGROUND : The healthcare market is facing a serious shortage of qualified personnel in @number@
BACKGROUND : The Healthy Aging Index ( HAI ) is a tool for measuring the extent of health and disease across multiple systems.
BACKGROUND : The hemodynamic force of wall shear stress ( WSS ) has demonstrated a critical role in atherogenesis.
BACKGROUND : The higher risk of women developing autoimmune diseases suggests that immune system is mediated by sex steroids.
BACKGROUND : The hippocampus is a brain region that is particularly affected by age-related morphological changes.
BACKGROUND : The home and community care sector is one of the fastest growing sectors globally and most prominently in mature industrialized countries.
BACKGROUND : The hormone klotho , encoded by the gene klotho , is primarily expressed in the kidney and choroid plexus of the brain.
BACKGROUND : The hormone klotho is encoded by aging-suppressor gene klotho and has multiple roles , including regulating mineral ( calcium and phosphate ) homeostasis.
BACKGROUND : The hospitalized elderly are at risk of functional decline.
BACKGROUND : The human body adopts a number of strategies to maintain an upright position.
BACKGROUND : The human cytosolic thioredoxin ( Trx ) contains a redox-active dithiol moiety in its conserved active-site sequence.
BACKGROUND : The human immunodeficiency virus ( HIV ) is associated with cognitive impairment , and loneliness is associated with cognitive decline in old age.
BACKGROUND : The humanities are increasingly recognized as an important component of medical student education.
BACKGROUND : The human RECQ DNA helicase family is involved in genomic stability.
BACKGROUND : The Hypogonadism Impact of Symptoms Questionnaire Short Form ( HIS-Q-SF ) is a patient-reported outcome measurement designed to evaluate the symptoms of hypogonadism.
BACKGROUND : The identification and assessment of adverse drug reactions ( ADRs ) is very challenging especially among the older person.
BACKGROUND : the identification of modifiable risk factors for preventing disability in older individuals is essential for planning preventive strategies.
Background : The identification of novel rehabilitative impairments that are risk factors for mobility limitations may improve their prevention and treatment among older adults.
BACKGROUND : The impact of age on melanoma patient outcomes is uncertain.
BACKGROUND : The impact of multiple healthy lifestyle factors on survival time is unclear.
BACKGROUND : The impact of patient age on the risks of death or rehospitalization after primary prevention implantable ( ICD ) placement is uncertain.
BACKGROUND : The impending public health impact of Alzheimer's disease is tremendous.
BACKGROUND : The imperative action of the geriatric medicine is to prevent disability in older persons.
BACKGROUND : The importance of assessing proprioceptive function for rehabilitation after neurological or orthopedic injury has long been recognized.
BACKGROUND : The importance of cholesterol as a risk factor among older people , particularly among the very old , is controversial.
BACKGROUND : The importance of optimising medicines management for people with dementia has been emphasised through research and policy.
BACKGROUND : The incidence of atrial fibrillation ( AF ) is rising in the aging patients with congenital heart defects ( CHD ) .
BACKGROUND : The incidence of complicated choledochocystolithiasis is increasing with the aging of society in Japan.
BACKGROUND : The incidence of critical limb ischemia increases with the aging of the population.
BACKGROUND : The incidence of differentiated thyroid cancer ( DTC ) increases with age.
BACKGROUND : The incidence of herpes zoster ( HZ ) is increasing and poses a significant health concern to aging populations.
BACKGROUND : The incidence of hip fractures is increasing within the aging population.
BACKGROUND : The incidence of ischemia might be increased in the surgical repair of atherosclerotic unruptured aneurysms compared to non-atherosclerotic aneurysms.
BACKGROUND : The incidence of pyogenic vertebral osteomyelitis ( PVO ) has increased over the past two decades.
BACKGROUND : The incidence of TB in Michigan was @number@ per @number@ people in @number@ roughly half the U.S. incidence.
BACKGROUND : The incidence rate of acute myeloid leukemia ( AML ) was determined in the Calgary Metropolitan Area , a major Canadian city.
BACKGROUND : The increased demand for anti-aging treatments over the past decade has fueled the development of multimodality devices.
BACKGROUND : The increased incidence of health challenges with aging means that nurses are increasingly caring for older adults , often in hospital settings.
BACKGROUND : The increased injury risk in older runners has been associated with alterations in muscle strength , flexibility , and gait biomechanics.
BACKGROUND : The increased need for professional expertise in the domain of aging is accompanied by a lack of academic experts in geropsychology.
BACKGROUND : The increasing burden of pneumonia in adults is an emerging health issue in the era of global population aging.
BACKGROUND : The increasing incidence of hip fractures in our aging population challenges orthopedic surgeons and hospital administrators to effectively care for these patients.
Background : the increasing prevalence of Alzheimer's dementia ( AD ) has shifted the burden of management towards primary care ( PC ) .
BACKGROUND : The increasing use of injectable fillers has been increasing the occurrence of disfiguring anaerobic infection or granulomas.
BACKGROUND : The independent and combined associations of muscle strength and obesity on the prevalence of type @number@ diabetes in Japanese men remain unclear.
BACKGROUND : The influence of aging on video capsule endoscopy ( VCE ) in obscure gastrointestinal bleeding ( OGIB ) has never been prospectively assessed.
BACKGROUND : The infrarenal abdominal aorta exhibits increased disease susceptibility relative to other aortic regions.
BACKGROUND : The inhibitory effect of adenosine on platelet aggregation is abrogated after the addition of adenosine-deaminase.
BACKGROUND : The integration of mental and neurologic services in healthcare is a global priority.
BACKGROUND : The interest of epidemiological research about male's aging increased in recent years along with the need to evaluate health-related quality of life.
BACKGROUND : The Internet is a key provider of health information , but little is known about its associations with cancer-preventive behaviors.
BACKGROUND : The issue of ageing within the cohort of people with intellectual disabilities has been an increasing focus for research.
BACKGROUND : The issue of osteoporosis-induced fractures has attracted the world's attention.
BACKGROUND : The Knowledge about Older Patients-Quiz ( KOP-Q ) is designed as a unidimensional scale measuring knowledge of hospital nurses about older patients.
BACKGROUND : The knowledge base regarding the pathogenesis of postoperative delirium is limited.
BACKGROUND : The Kumamoto Acute Coronary Events Study explored trends for acute myocardial infarction ( AMI ) .
BACKGROUND : The lack of a consistent model means that the quality and characteristics of memory services can vary greatly.
BACKGROUND : The Lao People's Democratic Republic is facing a critical shortage and maldistribution of health workers.
BACKGROUND : The last decades have seen great advances in the understanding , treatment , and prevention of cardiovascular disease ( CVD ) .
BACKGROUND : The lateral geniculate nucleus ( LGN ) is a key relay center of the visual system.
BACKGROUND : The left atrial appendage ( LAA ) is considered the most frequent site of intracardiac thrombus formation.
BACKGROUND : The literature is inconsistent and inconclusive on the relationship between bone mineral density ( BMD ) and muscular strength in postmenopausal women.
BACKGROUND : The longitudinal cognitive course in Parkinson's disease ( PD ) with and without dementia remains undefined.
BACKGROUND : The lower limb muscle may play an important role in decreasing the heart's pumping workload.
BACKGROUND : The lung age equations developed by the Japanese Respiratory Society encounter several problems when being applied in a clinical setting.
BACKGROUND : The management of type @number@ diabetes mellitus in long-term care ( LTC ) settings can be complex as a result of age-related complications.
BACKGROUND : The manufacturers of permanent injectable fillers claim that their products are widely inert , biocompatible , atoxic , and nonimmunogenic.
BACKGROUND : The Mean Heart Rate ( MHR ) tends to decrease with age.
BACKGROUND : The measurement of neuropsychiatric symptoms ( NPS ) in dementia is often based on caregiver report.
BACKGROUND : The mechanism for hypercoagulability in malignancy is not entirely understood.
BACKGROUND : The mechanisms by which testosterone increases hemoglobin and hematocrit remain unclear.
BACKGROUND : The mechanisms underlying the dedifferentiation and lineage conversion of adult human fibroblasts into functional endothelial cells have not yet been fully defined.
BACKGROUND : The medial thigh remains a troublesome region for body contouring in both the aging patient and in the massive weight loss patient.
BACKGROUND : The median age of the single adult homeless population is @number@ and rising.
BACKGROUND : The metabolic syndrome ( MetS ) is a cluster of cardiovascular risk factors which has been linked with a decline in muscle mass.
BACKGROUND : The Mini-Mental State Examination ( MMSE ) is widely used in schizophrenia , although normative data are lacking in this population.
BACKGROUND : The mitral valve has a complex three-dimensional ( 3D ) morphology that is incompletely described by two-dimensional echocardiography ( echo ) .
BACKGROUND : The modifiable factors associated with blood pressure variability ( BPV ) are still being established and their clinical relevance is poorly understood.
BACKGROUND : The Montreal Cognitive Assessment ( MoCA ) is a very widely used test for mild cognitive impairment.
BACKGROUND : The mortality prediction represents a key factor in the managing of elderly hospitalized patients.
BACKGROUND : The nail unit is an important part of cosmetic appearance of an individual.
BACKGROUND : The natural course and clinical significance of delirium in the emergency department ( ED ) is unclear.
BACKGROUND : The natural history of thyroid function in adults with Down syndrome is relatively unknown with limited long-term follow-up data.
BACKGROUND : the need for access to high-quality palliative care at the end of life is becoming of increasing public health concern.
BACKGROUND : The Nine-Card Sorting Test provides valid and reliable scores when screening executive function , intelligence , and academic achievement.
BACKGROUND : The north coast of Guadalcanal has some of the most intense malaria transmission in the Solomon Islands.
BACKGROUND : The number of children that SCUBA dive is increasing.
BACKGROUND : The number of chronic musculoskeletal pain sites ( nCMSP ) is reportedly associated with risk of falls.
BACKGROUND : The number of clinical trials including older patients , and particularly patients with cognitive impairment , is increasing.
BACKGROUND : The number of elderly patients with asthma has been increasing in Japan.
BACKGROUND : The number of new world records has decreased substantially in most athletic events in recent years.
BACKGROUND : The number of patients requesting surgical procedures performed for brachioplasty and massive weight loss is increasing.
BACKGROUND : The number of people living with dementia and mild cognitive impairment ( MCI ) is increasing substantially.
BACKGROUND : The numbers of patients > 85 years of age referred for abdominal aortic aneurysm ( AAA ) repair have increased in recent decades.
BACKGROUND : The nutritional status of the aging individual results from a complex interaction between personal and environmental factors.
BACKGROUND : The \ "obesity paradox \ " is poorly understood in vulnerable older hospitalized populations.
BACKGROUND : The objective of the study was to evaluate health aspects in elderly individuals in social , institutional , and home care in Poland.
BACKGROUND : The older patient population is significantly different from the younger adult population with regards to dose selection for a wide variety of drugs.
BACKGROUND : The oldest old ( 85 + ) are the fastest growing population segment in New Zealand.
BACKGROUND : The oldest old represent a unique group of older adults.
BACKGROUND : The \ "optimal \ " extent of myocardial revascularization remains to be determined.
BACKGROUND : The optimal level of sodium intake remains controversial.
BACKGROUND : The optimal schedule and the need for a booster dose are unclear for Haemophilus influenzae type b ( Hib ) conjugate vaccines.
BACKGROUND : The osseous morphology of the patellofemoral joint is an independent factor that affects the biomechanics of patellofemoral instability.
BACKGROUND : The overall age-standardized cancer incidence rate continues to decline whereas the number of cases diagnosed each year increases.
BACKGROUND : The P300 is a major index used to evaluate improvements in brain function.
BACKGROUND : The paradoxical phenomenon of relative longevity among obese patients with established diseases has been reported for various disease conditions.
BACKGROUND : The pathogenesis of abdominal aortic aneurysm is associated with changes of several components of arterial wall.
BACKGROUND : The pathogenesis of acrodermatitis chronica atrophicans ( ACA ) is not well understood.
BACKGROUND : The pathogenesis of rhegmatogenous retinal detachment is complex , and our knowledge of the exact mechanism of vitreoretinal attachment and detachment remains incomplete.
BACKGROUND : The Patient Protection and Affordable Care Act ( ACA ) galvanised debate in the United States ( US ) over universal health coverage.
BACKGROUND : The performance of alcohol septal ablation ( ASA ) in elderly symptomatic patients with drug-refractory obstructive hypertrophic cardiomyopathy is still to be confirmed.
BACKGROUND : The phenomenon of aging is increasing worldwide.
BACKGROUND : The physiological aging of the eye is associated with loss of visual function.
BACKGROUND : The physiological processes in the cell are regulated by reversible , electrostatic protein-protein interactions.
BACKGROUND : The plasma level of cystatin C is a better marker than plasma creatinine for successful aging.
BACKGROUND : The platysma is a superficial muscle involved in important features of the aging neck.
BACKGROUND : The pleckstrin and Sec7 domain-containing @number@ ( PSD3 ) gene has been linked to immune diseases.
BACKGROUND : The population ≥65 years is rapidly increasing , but remarkably little is known about the natural history of abdominal pain with ageing.
BACKGROUND : The population in Japan is aging more rapidly than in any other country.
BACKGROUND : The population is aging.
BACKGROUND : The population is aging and multimorbidity is becoming a common problem in the elderly.
BACKGROUND : The population of oldest old is increasing , but the prevalence of cognitive impairment is not well characterized in this group.
BACKGROUND : The population of people with opioid use disorders ( OUD ) is aging.
BACKGROUND : The population of the Western world is aging while cancer survival rates are rising.
BACKGROUND : The populations of many developed countries have been aging in recent years , resulting in increasing numbers of elderly-related injuries.
BACKGROUND : The postmenopausal phase has been considered an aggravating factor for developing metabolic syndrome.
BACKGROUND : The potential contribution of allotment gardens to a healthy and active life-style is increasingly recognized , especially for elderly populations.
BACKGROUND : The presence of metabolic syndrome in patients with hypertension significantly increases the risk of cardiovascular disease , type @number@ diabetes and mortality.
BACKGROUND : The present study aimed at characterizing the effects of increasing ( relative ) force level and aging on isometric force control.
BACKGROUND : The present study sets out to determine normal corneal sensitivity in five corneal regions and its changes with age in an Iranian population.
BACKGROUND : The prevalence of cardiovascular diseases ( CVD ) in HIV-infected patients increases with aging and duration of the disease.
BACKGROUND : The prevalence of chronic pain and sleep disturbances substantially increases with age.
BACKGROUND : The prevalence of extended-spectrum β-lactamase producing Enterobacteriaceae ( ESBL-E ) is increasing worldwide.
BACKGROUND : The prevalence of gastroesophageal reflux disease ( GERD ) has been increasing worldwide over recent decades.
BACKGROUND : The prevalence of hearing loss increases rapidly with aging.
BACKGROUND : The prevalence of heart failure ( HF ) is rising in industrialized and developing countries.
BACKGROUND : The prevalence of HIV-associated neurocognitive disorders ( HAND ) has not changed considerably in the last two decades.
BACKGROUND : The prevalence of idiopathic planovalgus decreases with age among children and adolescents.
BACKGROUND : The prevalence of overweight and obesity has increased in all age groups , including older adults.
BACKGROUND : the prevalence of sarcopenia varies widely between studies.
BACKGROUND : The prevalence of tendinopathies is increased in subjects with diabetes mellitus.
BACKGROUND : The prevalence of trauma-related psychiatric disorders is high among refugees.
BACKGROUND : The prevention and treatment of diseases related to changes in body composition require accurate methods for the measurement of body composition.
BACKGROUND : The primary outcome measures for patients who undergo aesthetic facial procedures are quality of life and satisfaction with appearance.
BACKGROUND : The production of erythropoietin is triggered by impaired oxygen delivery to the kidney , either because of anemia or hypoxemia.
BACKGROUND : The prognosis for patients aged over @number@ years who receive a pacemaker in the context of sinus node dysfunction is unclear.
BACKGROUND : The promotion of active and healthy ageing is becoming increasingly important as the population ages.
BACKGROUND : The proportion of elderly ( ≥65 years ) kidney transplant recipients ( KTRs ) doubled in the United States from @number@ to @number@
BACKGROUND : The proportion of European elderly is expected to increase to @percent@ in @number@
BACKGROUND : The proportion of older people among the general population has risen.
BACKGROUND : The published correlations between treadmill performance and the Walking Impairment Questionnaire ( WIQ ) score are generally fair.
BACKGROUND : The purpose of this meta-analysis was to evaluate the epidemiology of contrast-induced acute kidney injury ( CI-AKI ) in the elderly.
BACKGROUND : The purpose of this study is to determine if the three-step Luria test is useful for differentiating between cognitive disorders.
BACKGROUND : The purpose of this study was to investigate changes in delta event-related oscillations ( EROs ) in younger and older healthy elderly subjects.
BACKGROUND : The quaking viable ( qk ( v ) ) mouse has several developmental defects that result in rapid tremors in the hind limbs.
BACKGROUND : The quality of life of nursing home residents has increasingly become an important dimension when evaluating care in a nursing home.
BACKGROUND : the Random Gap Detection Test ( RGDT ) evaluates temporal resolution threshold.
BACKGROUND : The rank product method is a powerful statistical technique for identifying differentially expressed molecules in replicated experiments.
BACKGROUND : There are concerns about the potential for unintentional harms when clinical practice guidelines are applied to patients with multimorbidity.
BACKGROUND : There are concerns that automated drug dispensing may increase inappropriate drug use.
BACKGROUND : There are conflicting results about the association between body mass index ( BMI ) and depressive symptoms in older adults.
BACKGROUND : There are currently no published reports of dementia prevalence or factors associated with dementia occurrence in Bangladesh.
BACKGROUND : There are few established predictors of the clinical course of PD.
BACKGROUND : There are few reports on the age-specific clinical features of upper cervical spine injury.
BACKGROUND : There are few studies on the long-term associations of physical activity ( PA ) to cognition.
BACKGROUND : There are growing numbers of older parents providing ongoing care for adults with disabilities.
BACKGROUND : There are inequities in health status associated with ethnicity , which may limit older foreign-born persons ' ability to age optimally.
BACKGROUND : There are limited data on patients aged > 75 years with myocardial infarction ( MI ) , especially those who are treated conservatively.
BACKGROUND : There are many approaches to evaluating aging-in-place technologies.
BACKGROUND : There are many different visible signs of skin aging.
BACKGROUND : there are no accurate methods for the assessment of food intake in older populations , under-reporting of intake being highly prevalent.
Background : There are no primary prevention trials of aspirin with relevant geriatric outcomes in elderly people.
BACKGROUND : There are only a few reports which provide prevalence rates of mild cognitive impairment ( MCI ) and dementia specifically in Arabic countries.
BACKGROUND There are several genes and genetic loci affecting telomere length , including hTERT gene and BICD1 gene as well as polymorphisms within chromosome @number@
BACKGROUND : There are situations where a pharmacokinetic ( PK ) study may not be possible in children , especially in neonates and infants.
BACKGROUND : The regenerative property of fat grafting has been described.
BACKGROUND : There has an increasing number of published trials on psychosocial intervention programmes for pre-school children with autism spectrum disorder ( ASD ) .
BACKGROUND : There has been considerable interest in whether old age is associated with IgA nephropathy ( IgAN ) progression , which is still controversial.
BACKGROUND : There has been limited research exploring socioeconomic inequity in targeted preventive care for acute myocardial infarction ( AMI ) .
BACKGROUND : There have been conflicting reported associations between dietary factors and incident atrial fibrillation ( AF ) .
BACKGROUND : There have been many attempts to search for affordable and effective functional cosmetic ingredients , especially from natural sources.
BACKGROUND : There is a functional decline of endothelial- dependent vasodilatation in the aging process.
BACKGROUND : There is a gap between the knowledge in the broad dementia research literature and transfer of knowledge into practice.
BACKGROUND : There is a general concern that aged organs are more susceptible to ischaemia.
BACKGROUND : There is a growing awareness of the need to include the oldest age groups in the epidemiological monitoring of alcohol consumption.
BACKGROUND : There is a growing body of literature indicating that attitudes toward aging significantly affect older adults ' psychological well-being.
BACKGROUND : There is a growing interest in simple molecular biomarkers for biological aging.
BACKGROUND : There is a lack of consensus on the diagnosis of sarcopenia.
BACKGROUND : There is a loss of lean body mass ( LBM ) with increasing age.
BACKGROUND : There is a need for short , specific instruments that assess quality of life ( QOL ) adequately in the older adult population.
BACKGROUND : There is an increasing number of older adults living with long-term musculoskeletal pain and related disabilities.
BACKGROUND : There is a paucity of adequate and validated instruments for the measurement of successful aging for geriatric researchers in Chile.
BACKGROUND : There is consensus that dementia is the most burdensome disease for modern societies.
BACKGROUND : There is currently no validated questionnaire available to assess total sedentary time in older adults.
BACKGROUND : There is growing evidence for the ongoing structural and functional adaptation of the skin after birth.
BACKGROUND : There is growing evidence of the involvement of executive control in the maintenance of balance in old age.
BACKGROUND : There is growing evidence that cognitive training ( CT ) can improve the cognitive functioning of the elderly.
Background : There is growing interest in identifying interventions that may increase health span by targeting biological processes underlying aging.
BACKGROUND : There is increasing emphasis in policy , research and practice on the importance of caring in health care.
BACKGROUND : There is increasing evidence that chronic stress accelerates telomere erosion in leukocytes / peripheral blood mononuclear cells ( PBMCs ) .
BACKGROUND : There is increasing evidence that insulin resistance is associated with endothelial dysfunction.
BACKGROUND : There is increasing need for rehabilitation in both cancer and palliative care.
BACKGROUND : There is increasing recognition that lower nurse staffing levels are associated with higher morbidity and mortality among medical and surgical patients.
BACKGROUND : There is limited information on genetic factors associated with sudden cardiac arrest ( SCA ) .
BACKGROUND : There is limited research about beneficial effects of physical activity in older adults suffering from mild cognitive impairment ( MCI ) .
BACKGROUND : There is limited research examining the chemical load of toxic metals in the elderly.
BACKGROUND : there is limited research examining the relative importance of aspects of quality of life ( QOL ) to older adults across cultures.
BACKGROUND : There is little information on the association of the APOEe4 allele and AD risk in African populations.
BACKGROUND : There is little knowledge about the consumption of alcohol among Chinese and Norwegian older adults aged @number@ years and over.
BACKGROUND : There is mixed evidence suggesting that air pollution may be associated with increased risk of developing psychiatric disorders.
BACKGROUND : there is no established definition of healthy aging in clinical practice , although it is a World Health Organization goal.
BACKGROUND : there is no longitudinal evidence about the association between the loss of total appendicular skeletal muscle ( TASM ) and cytokines.
BACKGROUND : There is paucity of information regarding time trends of weight status in children from rapidly developing economies like India.
BACKGROUND : There is some debate over of the effect of aging on the ability to recognize previously processed information.
BACKGROUND : The relationship between adiponectin concentration and mortality is unclear.
BACKGROUND : The relationship between aging in the vestibular system and aging in the cochlea is a topic of ongoing investigation.
BACKGROUND : The relationship between executive functions ( EF ) and gait speed is well established.
BACKGROUND : The relationship between osteoporosis ( OP ) and osteoarthritis ( OA ) is yet unclear.
BACKGROUND : The relationship between resting heart rate ( RHR ) and incident heart failure ( HF ) has been questioned.
BACKGROUND : The relationship between the metabolic syndrome and subclinical atherosclerosis among elderly people remains controversial.
BACKGROUND : The relationship between the olfactory system and emotional processing is an area of growing interest in schizophrenia research.
BACKGROUND : The relationship between the pathophysiology of dementia and neuroinflammation is well-known.
BACKGROUND : The relationship between weight problems and depression has been the focus of many studies ; however , results from these studies vary.
BACKGROUND : The relationships between N-terminal fragment proBNP ( B-type natriuretic peptide ) ( NT-proBNP ) and sex steroid hormones have not been fully elucidated.
BACKGROUND : The relationships between renal function and specific domains of cognitive function have rarely been explored in representative , community-based samples of older adults.
BACKGROUND : The replacement of hard tissues demands biocompatible and sometimes bioactive materials with properties similar to those of bone.
BACKGROUND : The review of methodological problems ( confounding factors ) of gait analysis in intervention studies with seniors is underrepresented.
BACKGROUND : There were numerous efforts in the United States during the previous decade to concentrate selected surgical procedures in high-volume hospitals.
BACKGROUND : The risk of Herpes Zoster ( HZ ) increases with age and various studies have also demonstrated an increasing HZ incidence globally.
BACKGROUND : The risk of incorrect medication dosing is high in frail older people.
BACKGROUND : The risk of unexplained fetal death or stillbirth increases late in pregnancy , suggesting that placental aging is an etiological factor.
BACKGROUND : The role of eating frequency on relative weight in childhood is not well understood.
BACKGROUND : The role of estrogens on moles biology remains undefined although estrogenic receptors have been found on melanocytes.
BACKGROUND : The role of the extracranial venous system in the pathology of central nervous system ( CNS ) disorders and aging is largely unknown.
BACKGROUND : The role of the orexigenic hormone ghrelin is of major interest in the altered appetite regulation of the elderly.
BACKGROUND : The Ryanodine receptor @number@ gene ( RYR3 ) encodes an intracellular calcium channel that mediates the efflux of Ca2 + from intracellular stores.
BACKGROUND : the safety of older pedestrians at urban intersections is a matter of gerontological concern.
BACKGROUND : The sagittal alignment of the spine changes depending on body posture and degenerative changes.
BACKGROUND : The second derivative of the finger plethysmogram ( SDPTG ) comprises five waves termed a to e.
BACKGROUND : The serum level of amylase ( sAm ) is commonly used as a biochemical marker for diagnosis and management of pancreatic disorders.
BACKGROUND : The shapes of the eyebrow and upper eyelid are distinctive facial landmarks.
BACKGROUND : The shortage of physicians in Japan is a serious concern , particularly in specialties like pediatrics.
BACKGROUND : The Short Physical Performance Battery ( SPPB ) is a well-established tool to assess lower extremity physical performance status.
BACKGROUND : The shuttle walking test ( SWT ) is a simple , widely used method for assessing endurance performance in the elderly.
BACKGROUND : The size of the rapidly exchanging pool of body zinc has been suggested as having potential utility as a biomarker of zinc status.
BACKGROUND : The Skin Products Assessment Research Committee was created by the Plastic Surgery Educational Foundation in @number@
BACKGROUND : The soluble form of the receptor for advanced glycation end-products ( sRAGE ) has been studied in various diseases.
BACKGROUND : The St. George's Respiratory Questionnaire ( SGRQ ) was a widely used tool to assess disease impact on patients with obstructive airways disease.
BACKGROUND : the STOPP criteria advise against the use of long-acting benzodiazepines ( LBs ) .
BACKGROUND : The stromal vascular fraction ( SVF ) of adipose tissue consists of cellular subpopulations with distinct regenerative potential.
BACKGROUND : The strongest known risk factor for endometrial cancer is obesity.
BACKGROUND : The success of behavioural interventions to optimize cardiovascular health is dependent on adequate cognitive functioning beginning in early life.
BACKGROUND : The sum of environmental and genetic factors affects the appearance and function of the skin as it ages.
BACKGROUND : The surgical population is aging , and greater numbers of surgical patients are being discharged to skilled nursing facilities.
BACKGROUND : The sustainability of long-term care ( LTC ) is a prominent policy priority in many Western countries.
BACKGROUND : The sweeping obesity epidemic could further increase the incidence of functional limitations in the U.S. rapidly aging population.
BACKGROUND : The tear trough and palpebromalar groove are of increasing interest to plastic surgeons , but their mechanisms of formation remain unclear.
BACKGROUND : the terminal decline hypothesis suggests an acceleration in the rate of loss of cognitive function before death.
BACKGROUND : The transconjunctival lower eyelid blepharoplasty is advantageous for its quick recovery and low complication rates.
BACKGROUND : The treatment of older patients with schizophrenia and depressive symptoms poses many challenges for clinicians.
BACKGROUND : The typical changes to hair associated with ageing are greying , thinning , dryness and brittleness.
BACKGROUND : The underlying molecular mechanisms of the vasculoprotective effects of physical exercise are incompletely understood.
BACKGROUND : The understanding of facial fat volume change with aging is essential for facial rejuvenation.
BACKGROUND : The United Nations ' Global Population Pyramid is undertaking a shift from pyramid to cube.
BACKGROUND : The United States has the highest incarceration rate in the world which has created a public health crisis.
BACKGROUND : The unprecedented global growth in older adults merits high-quality gerontological nursing care.
BACKGROUND : The use of botulinum toxin has rapidly expanded into various aesthetic applications.
BACKGROUND : The use of drugs with anticholinergic properties ( AC drugs ) has been associated with decreased functioning and impaired cognition in older adults.
BACKGROUND : The use of ( FRIDs ) has been associated with increased risk of falls and associated injuries.
BACKGROUND : The use of high-intensity interval training ( HIIT ) is widely diffused as strategy to enhance aerobic fitness and body composition.
BACKGROUND : The use of insoles may enhance postural stability and prevent falls.
BACKGROUND : The use of levothyroxine to treat subclinical hypothyroidism is controversial.
BACKGROUND : The use of potentially inappropriate medications in older adults can lead to known adverse drug events , but long-term effects are less clear.
BACKGROUND : The use of proton pump inhibitors ( PPIs ) in older adults is high , often inappropriate , and may cause harm.
BACKGROUND : The U.S. population is aging and increasingly culturally diverse.
BACKGROUND : The Veterans Aging Cohort Study ( VACS ) index is a weighted combination of age and @number@ clinical variables.
BACKGROUND : The white blood cell ( WBC ) count was one of the first inflammatory markers associated with metabolic syndrome ( MetS ) .
BACKGROUND : The Wnt / β-catenin signaling pathway plays a central role during cardiac development and has been implicated in cardiac remodeling and aging.
BACKGROUND : The Work Ability Model has a holistic structure that incorporates individual characteristics , work-related factors and life outside of work.
BACKGROUND : The world's population aged @number@ and over will more than triple from @number@ million to @number@ billion between the years @number@ to @number@
BACKGROUND : The world's population is aging , and the need for nurses is increasing.
BACKGROUND : the worldwide population is ageing.
BACKGROUND : Thiamine deficiency has suggested to be linked to several insulin-resistance complications.
BACKGROUND : Thioredoxin ( TRX ) -1 , a ubiquitous 12-kDa protein , exerts antioxidant and anti-inflammatory effects.
BACKGROUND : This cross-sectional study examined the associations of hormones and age with short-term memory and perceptual capacity in @number@ healthy Asian men.
BACKGROUND : This paper describe the development of interRAI's second-generation home care quality indicators ( HC-QIs ) .
BACKGROUND : This pilot study compared a monophasic hyaluronic acid dermal filler with a biphasic filler for the correction of nasolabial folds.
BACKGROUND : This retrospective study documents the proportion of hand clinic patients presenting with palmar fibromatosis with and without contracture.
BACKGROUND : This study aimed to estimate coverage and identify factors associated to vaccination against influenza in the elderly population.
BACKGROUND : This study aimed to explore the prevalence and correlates of anxiety disorders and any anxiety symptoms among community-dwelling U.S. Chinese older adults.
BACKGROUND : This study aimed to investigate the impact of aging on electrophysiological characteristics in patients with atrioventricular nodal re-entrant tachycardia ( AVNRT ) .
BACKGROUND : This study assessed the relationship between and risk factors for microvascular complications of diabetes in an urban South Indian type @number@ diabetes population.
BACKGROUND : This study attempts to examine the impact of socioeconomic and medical conditions in health and healthcare utilization among older adults in Ghana.
BACKGROUND : This study compared the reversibility of rocuronium-induced profound neuromuscular block with sugammadex in younger and older patients.
BACKGROUND : This study compares handgrip strength and its association with mortality across studies conducted in Moscow , Denmark , and England.
BACKGROUND : This study compares the health-related quality of life of Spanish-born and Latin American-born individuals settled in Spain.
BACKGROUND : This study examined the motivations and experiences of anonymous donors who decide to make themselves open to contact with their donor offspring.
BACKGROUND : This study explored the relationship between \ "worthlessness \ " and all cause non-suicide mortality in Chinese elderly men.
BACKGROUND : This study explores changes in the leisure-time physical activities of Canadian adults over time.
BACKGROUND : This study investigated gender differences in the relationship between alcohol consumption and cognitive impairment among older adults in South Korea.
BACKGROUND : This study investigates how T ( @number@ ) -weighted MRI can be used to evaluate brain anatomical changes.
BACKGROUND : This study looked at clinical and histological outcomes of patients treated with Integra more than @number@ years earlier.
BACKGROUND : This study was aimed toward discerning depressive symptom trajectories associated with different chronic conditions and toward finding modifiable factors associated with those trajectories.
BACKGROUND : This study was part of a Phase @number@ program treating crow's feet lines ( CFL ) with onabotulinumtoxinA.
BACKGROUND : This systematic literature review is aimed at investigating applications of direct-to-consumer hearing devices for adults with hearing loss.
BACKGROUND : This was the second study in a Phase @number@ program treating crow's feet lines ( CFL ) with onabotulinumtoxinA.
BACKGROUND : Three dimensional ( 3D ) skin rejuvenation is proposed to be effective for all skin layers.
BACKGROUND : Three-dimensional ( 3D ) speckle-tracking echocardiography ( STE ) is an emerging technology used to quantify left ventricular ( LV ) function.
BACKGROUND : Three versions of Perceived Stress Scale ( PSS-14 , PSS-10 , and PSS-4 ) are among the most widely used measures of stress.
BACKGROUND : Thrombocytopenia is a common finding in several diseases but almost nothing is known about the prevalence of thrombocytopenia in the general population.
BACKGROUND : Thromboxane synthase ( TXS ) metabolizes prostaglandin H2 into thromboxanes , which are biologically active on cancer cells.
BACKGROUND : Thyroid disease and hyperparathyroidism are the most common endocrine disorders.
BACKGROUND : To analyse the differences in the self-estimate of life quality depending on the ageing type - passive , active.
BACKGROUND : To analyze the effects of age , cataract surgery and postoperative period on macular pigment optical density ( MPOD ) .
BACKGROUND : To assess central corneal thickness and related factors in an elderly American Chinese population residing in San Francisco.
BACKGROUND : To avoid symptoms , patients with COPD may reduce the amount of activities of daily living ( ADL ) .
BACKGROUND : Tobacco smoking may cause skin aging through mast cell proteinases.
BACKGROUND : To compare life span of persons with and without ocular pseudoexfoliation syndrome ( PES ) .
BACKGROUND : To date , little is known about the association between dietary pattern and disability in older adults.
BACKGROUND : Today , an increasing number of total hip arthroplasty ( THA ) procedures are being performed.
BACKGROUND : To define age-related changes in the visual field by comparing ' standard ' central and unique peripheral visual field measurements in healthy volunteers.
BACKGROUND : To develop a prediction model that predicts disability in community-dwelling older people.
BACKGROUND : Toe flexor muscles play an important role in posture and locomotion , and poor toe flexor strength is a risk factor for falls.
BACKGROUND : To evaluate a potential correlation between flexural strength and indirect tensile strength in assessing the mechanical strength of resin composite cements.
BACKGROUND : To evaluate the effectiveness of the minimally traumatic midface lift approach in combination with the Wrinkle Severity Rating Scale ( WSRS ) criteria.
BACKGROUND : To evaluate the outcome of surgical treatment of acute lower limb ischemia in elderly patients.
BACKGROUND : To evaluate the trend of prostate cancer mortality in Taiwanese general population and the association between diabetes and prostate cancer mortality.
BACKGROUND : To evaluate time course and predictors of progression of paroxysmal or persistent atrial fibrillation ( AF ) to permanent AF.
BACKGROUND : To examine outcomes after pelvic exenteration in women treated with modern chemoradiation and surgical techniques.
BACKGROUND : To examine the impact of educational attainment on the incidence of preclinical mobility disability ( PCD ) .
BACKGROUND : To examine whether offspring improve or reduce quality of life ( QOL ) among cancer patients and survivors.
BACKGROUND : Tofu from aged soybeans is of poor quality , mainly with respect to texture.
BACKGROUND : To influence dietary behaviors , more insight in food choice motivations is necessary.
BACKGROUND : To prepare for a super-aging society , effective dementia screening tests are required.
BACKGROUND : Total knee arthroplasty ( TKA ) is the most frequently performed joint replacement surgery in North America.
BACKGROUND : Total sedentary time varies across population groups with important health consequences.
BACKGROUND : To which extent serum cytokines may predict asthma control in adults remains understudied.
BACKGROUND : Traditionally , non-communicable diseases including musculoskeletal disorders have not been a priority in low-and-middle income countries.
BACKGROUND : Traditionally , @number@ years ago , children born preterm often routinely received morphine , especially during mechanical ventilation.
BACKGROUND : Traffic-related air pollution has been associated to a range of adverse health impacts , including decreased heart rate variability ( HRV ) .
BACKGROUND : Traffic-related particles induce oxidative stress and may exert adverse effects on central nervous system function , which could manifest as cognitive impairment.
BACKGROUND : Training programs directed to improve neuromuscular and musculoskeletal function of the legs are scarce with respect to older osteoporotic patients.
BACKGROUND : Transcatheter aortic-valve implantation ( TAVI ) has been shown to improve survival and quality of life in patients with severe aortic stenosis.
BACKGROUND : Transcriptomic studies hold great potential towards understanding the human aging process.
BACKGROUND : Transfusion of blood components may increase the risk of complications in relation to surgery.
BACKGROUND : Translation of intensive exercise programs developed specifically for patients with dementia into clinical settings is lacking.
BACKGROUND : Transplantation is often the only way to treat a number of diseases leading to organ failure.
BACKGROUND : Trauma and depression have each been associated with neurocognitive alterations , but their combined effect on neurocognition is unclear.
Background : Traumatic brain injury ( TBI ) has been identified as a risk factor for Parkinson's disease ( PD ) .
BACKGROUND : Traumatic brain injury ( TBI ) is extremely common across the lifespan and is an established risk factor for dementia.
BACKGROUND : Treatment and care of elderly patients with diabetes and hypertension means a hard task in primary care.
BACKGROUND : Tremor is a common feature of a variety of neurological disorders.
BACKGROUND : Tremor is one of the most common neurological signs , yet its etiology is poorly understood.
BACKGROUND : Trust in physicians influences the health and well-being of older adults and is an important indicator to assess the quality of medical care.
BACKGROUND : Tryptophan metabolism through the kynurenine pathway includes @number@ vitamin B-6 [ pyridoxal @number@'-phosphate ( PLP ) ] -dependent enzymes.
BACKGROUND : Tuberculosis is a serious global health problem.
BACKGROUND : Tumor necrosis factor ( TNF ) levels are associated with risk for heart failure ( HF ) .
BACKGROUND : Twenty-four-hour ambulatory blood pressure ( BP ) patterns have been associated with diminished cognitive function in hypertensive and very elderly populations.
BACKGROUND : Two-stage facial reanimation procedures with a cross-facial nerve graft often have unsatisfactory results in the older patient.
BACKGROUND : UK care home residents are often poorly served by existing healthcare arrangements.
BACKGROUND : Ultrasonography has been widely applied for in vivo measurements of tendon mechanical properties.
BACKGROUND : Ultrasound elastography allows assessment of tissue elasticity.
BACKGROUND : Uncertainty exists with regards to the extent of prevalence and health care use for musculoskeletal disorders in Norway.
BACKGROUND : Uncomplicated frailty instruments are desirable for use in a busy clinical setting.
BACKGROUND : Under-eye bags are a common manifestation of age and a frequent complaint among patients who no longer feel youthful.
BACKGROUND : Understanding factors promoting symptom severity is essential to developing innovative symptom management models.
BACKGROUND : Understanding how urbanisation and rural-urban migration influence risk-factors for non-communicable disease ( NCD ) is crucial for developing effective preventative strategies globally.
BACKGROUND : Understanding optimum function in patients with HF can help advanced practice nurses ( APNs ) identify clinical signs of deterioration.
BACKGROUND : Understanding the anatomy of the lower eyelid and the lid-cheek junction is important for surgical and non-surgical approaches.
BACKGROUND : Understanding the relationship between organizational context and research utilization is key to reducing the research-practice gap in health care.
BACKGROUND : Under-treatment is frequently present in geriatric patients.
BACKGROUND : Unfavorable living conditions in old age have negative physical , psychological and social implications and increase the risk of institutionalization.
BACKGROUND : Unintentional loss of weight and muscle due to aging and disease has been associated with increased mortality.
BACKGROUND : Unlike traditional primary care centres , part of the Community Health Centre ( CHC ) mandate is to address upstream health determinants.
BACKGROUND : Unmet need for assistance with activities of daily living ( ADLs ) disability is associated with increased risk for future hospitalization.
BACKGROUND : Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer.
BACKGROUND : unplanned hospital admissions of older patients continue to attract the attention of UK policymakers , advisors and media.
BACKGROUND : Unsteady gait and falls are major problems for people with Parkinson's disease ( PD ) .
BACKGROUND : Upon encountering older adults , individuals display varying degrees of prosocial attitudes and behaviors.
BACKGROUND : Upper arm skin laxity is an important area of cosmetic concern.
BACKGROUND : Upper gastrointestinal endoscopy has been performed after fasting @number@ or more hours , which can be harmful to the patients.
BACKGROUND : Upper limb paresis is one of the most frequent and persistent impairments following stroke.
BACKGROUND : Urinary biomarkers are used in assessment of severe , clinical oxidative stress.
BACKGROUND : Urinary incontinence is a prevalent condition in the elderly that is the spontaneous leakage of urine.
BACKGROUND : Urinary incontinence ( UI ) , a prevalent condition among seniors , can have substantial impacts on quality of life.
BACKGROUND : Urinary tract infection ( UTI ) is a common complication among patients with hip fractures.
BACKGROUND : Urogenital symptoms affect up to half of women after menopause , but their impact on women's day-to-day functioning and wellbeing is poorly understood.
BACKGROUND : Use of botulinum toxin for esthetic purposes has rapidly expanded over the last @number@ years.
Background : Use of chemotherapy near the end of life in patients with metastatic cancer is often ineffective and toxic.
BACKGROUND : Use of colonoscopy is thought to reduce colorectal cancer ( CRC ) mortality , but its impact at the population level is unclear.
BACKGROUND : US studies suggest that leptin , a fat-derived hormone , may be protective against the development of dementia.
BACKGROUND : Vaccination uptake for the aging population in many countries still remains below the World Health Organization recommended rate.
BACKGROUND : Vaccine coverage estimates lag by years in the US.
BACKGROUND : Vague and inexact word usage can complicate conversations about cutaneous energy devices , especially novel technologies.
Background Valve-in-valve ( ViV ) procedures for degenerated bioprostheses are an alternative for the standard of care in an aging population.
BACKGROUND : Valvular and vascular calcification are important early aging phenotypes and represent risk factors for cardiovascular morbidity and mortality.
BACKGROUND : Valvular heart disease ( VHD ) and atrial fibrillation ( AF ) often coexist.
BACKGROUND : Variation in baseline ear temperature , taken in the unadjusted mode , has yet to be established in different age groups.
BACKGROUND : Variation in the serotonin transporter ( 5-HTT ) gene ( SLC6A4 ) has been shown to influence a wide range of affective processes.
BACKGROUND : Various factors including cardio-metabolic disorders are found to be correlated with frailty.
BACKGROUND : Various minimally invasive treatments enhance the skin's appearance.
BACKGROUND : Various preparations of botulinum toxin type A ( BTX-A ) are used to reduces glabellar ( frown ) lines.
BACKGROUND : Vascular and immune alterations in the prefrontal cortex may contribute to major depression in elderly subjects.
BACKGROUND : Vascular calcification is a major risk factor for cardiovascular diseases.
BACKGROUND : Vascular cognitive impairment ( VCI ) is a complex spectrum encompassing post-stroke cognitive impairment ( PSCI ) and small vessel disease-related cognitive impairment.
BACKGROUND : Vascular dementia ( VaD ) is the second most common type of dementia.
BACKGROUND : vascular disease has been postulated to contribute to muscle dysfunction in old age.
BACKGROUND : Vascular Ehlers-Danlos syndrome ( VEDS ) causes reduced life expectancy because of arterial dissections / rupture and hollow organ rupture.
BACKGROUND : Vascular endothelial growth factor ( VEGF ) -targeting drugs normalise the tumour vasculature and improve access for chemotherapy.
BACKGROUND : Vascular risk factors and lack of formal education may increase the risk of Alzheimer's disease ( AD ) .
BACKGROUND : Vascular risk factors such as hypertension and obesity have been associated with physical limitations among older adults.
BACKGROUND : Ventilator associated pneumonia ( VAP ) is a serious infection among patients in the intensive care unit ( ICU ) .
BACKGROUND : Ventral hernia repairs ( VHR ) are among the most common procedures performed by general surgeons.
BACKGROUND : Verbal fluency ( VF ) tasks are widely used in neuropsychological evaluations , as a measure of executive / semantic dysfunction.
BACKGROUND : very few studies have examined the association between intra-individual reaction time variability and subsequent mortality.
BACKGROUND : Veterans are prone to bone-related illnesses due to multiple risk factors such as prior injuries.
BACKGROUND : Vibration anesthesia is an effective pain-reduction technique for facial cosmetic injections.
BACKGROUND : Vision loss is associated with ageing , and its prevalence is increasing.
BACKGROUND : Visual impairment in elderly people is a considerable health problem that significantly affects quality of life of millions worldwide.
BACKGROUND : Visual impairment is more prevalent in the elderly and depression is common in this population.
BACKGROUND : Visuo-spatial and problem-solving abilities are commonly impaired in patients with Alzheimer's disease ( AD ) .
BACKGROUND : Vital pulp preservation in the treatment of deep caries is challenging due to bacterial infection.
BACKGROUND : Vitamin C has important physical and mental health benefits and plasma concentrations reflect recent intakes.
BACKGROUND : Vitamin C is commonly used to treat aged skin.
BACKGROUND : Vitamin D co-regulates the synthesis of sex hormones in part by interaction with its nuclear receptor.
BACKGROUND : Vitamin D deficiency has potential adverse effects on neurocognitive health and subcortical function.
BACKGROUND : Vitamin D has a basic role in bone growth and metabolism and has been noticed for its important role in many diseases.
BACKGROUND : Vitamin D insufficiency is associated with brain changes.
BACKGROUND : Vitamin D is associated with lung health in epidemiologic studies , but mechanisms mediating observed associations are poorly understood.
BACKGROUND : Vitamin D is essential for maintaining bone mineralization and calcium homeostasis , and prevents falls and fractures in older adults.
BACKGROUND : Vitamin D status is currently diagnosed by measuring serum 25-hydroxyvitamin D [ 25 ( OH ) D ] .
BACKGROUND : Vitamin-K antagonists ( VKAs ) present an effective anticoagulant treatment in deep venous thrombosis ( DVT ) .
BACKGROUND : Volume loss and muscular hyperactivity are two major components of the aging process that contribute to the formation of the folds and wrinkles.
BACKGROUND : Vulnerability is an important concept in nursing and nursing ethics.
BACKGROUND : VYC-15L ( Juvéderm Volbella XC ) is a nonanimal crosslinked hyaluronic acid ( HA ) gel with lidocaine.
BACKGROUND : Walking is a complex motor task that requires an integrated coordination of the trunk , lower limb , and upper limb movements.
BACKGROUND : Wearable sensors have the potential to provide clinicians with access to motor performance of people with movement disorder as they undergo intervention.
BACKGROUND : We are now facing rapid population aging in Japan , which will affect the actual situation of cardiovascular diseases.
BACKGROUND : we assessed the tolerability and efficacy of autologous skin cell grafts in older type @number@ diabetic patients with chronic foot ulcers.
BACKGROUND : We conducted a retrospective study to specify the effect of age and gender on echocardiographic left ventricular diastolic function parameters.
BACKGROUND : We currently have an incomplete understanding of which postoperative complications after coronary artery bypass grafting ( CABG ) are associated with long-term death.
Background : We currently still lack valid methods to dynamically measure resilience for stressors before the appearance of adverse health outcomes that hamper well-being.
BACKGROUND : We evaluated cognitive function and factors associated with cognitive impairment in a cohort of older homeless adults.
BACKGROUND : We evaluated whether quality of life correlates to age and activity in children following heart transplantation.
BACKGROUND : We examined emergency room ( ER ) utilization by persons with dementia ( PWDs ) using caregiver and patient characteristics as predictors.
BACKGROUND : We examined prospectively the use of all-cause hospital in-patient care among public sector employees by using a 3-year pre- and post-retirement study window.
BACKGROUND : We examined the associations between childhood socioeconomic status and adulthood height with functional limitations in old age.
BACKGROUND : We examined the associations between serum cholesterol measures , statin use , and cognitive function measured in childhood and in old age.
BACKGROUND : We examined the relationships between objective and self-reported sedentary time and health indicators among older adults residing in retirement communities.
BACKGROUND : We examined the sensitivity of different executive function measures for detecting deficits in Parkinson's disease patients without dementia.
BACKGROUND : We have been studying the thermoregulatory responses of Korean breath-hold women divers , called haenyeo , in terms of aging and cold adaptation.
BACKGROUND : We hypothesized that distinct biological processes might be associated with prognosis and chemotherapy sensitivity in the different types of breast cancers.
BACKGROUND : Weight gain after antiretroviral therapy ( ART ) initiation is common , but its implication for mortality is unknown.
BACKGROUND : Weight loss is associated with a higher mortality risk in old age , but the underlying cause may impact this association.
BACKGROUND : We investigated the viability of psychometrically robust executive function measures as markers for premanifest Huntington's disease ( HD ) .
BACKGROUND : We present the incidence and risk factors for major depressive disorder ( MDD ) among community-dwelling elderly Nigerians.
BACKGROUND : We previously reported that progenitor cells , or stem cells , exist within penile tissue.
BACKGROUND : We showed that obese insulin resistant postmenopausal women are characterized by higher lean body mass and elevated C-reactive protein.
BACKGROUND : We sought to investigate the relation between frailty indices and 12-month mortality after transcatheter aortic valve implantation ( TAVI ) .
BACKGROUND : We tested the hypothesis that a higher level of social activity was associated with decreased risk of incident disability in older adults.
BACKGROUND : What are the factors that affect the survival probability of becoming a centenarian for those aged @number@ ?
BACKGROUND : When a hospitalized older patient falls or develops delirium , there are significant consequences for the patient and the health care system.
BACKGROUND : When applying health-enabling technologies ( HET ) , researchers are faced with analyzing highly intensive , multimodal and heterogeneous data sets.
BACKGROUND : When individuals have hearing loss , physiological changes in their brain interact with relearning of sound patterns.
BACKGROUND : When the Mini Nutritional Assessment ( MNA ) was developed , the authors did not specifically focus on the nursing home setting.
BACKGROUND : Whether human immunodeficiency virus ( HIV ) infection is a risk factor for heart failure ( HF ) is not clear.
BACKGROUND : Whether life course anthropometric indices relate to cognitive function in midlife remains insufficiently explored.
BACKGROUND : Whether oxytocin functions as a stress hormone in older age is unknown.
BACKGROUND : whether socioeconomic position over the life course influences the wellbeing of older people similarly in different societies is not known.
BACKGROUND : While community-wide interventions to promote physical activity have been encouraged in older adults , evidence of their effectiveness remains limited.
BACKGROUND : While demographic shifts project an increased need for long-term care for an aging population , hundreds of nursing homes close each year.
BACKGROUND : While divided attention tasks are recognized as predictors of falls in older adults , a comprehensive examination of this association is lacking.
BACKGROUND : While electronic cigarettes are forbidden in several countries , their sales are exploding in many others.
BACKGROUND : While recent work emphasizes the multi-dimensionality of mobility , no current measure incorporates multiple domains of mobility.
BACKGROUND : While the impact of COPD in Western-Europe is known , data from Eastern-Europe is scarce.
BACKGROUND : While there have been efforts to develop frameworks to guide healthcare priority setting ; there has been limited focus on evaluation frameworks.
BACKGROUND : White matter hyperintensities may contribute to depression by disrupting neural connections among brain regions that regulate mood.
BACKGROUND : White matter hyperintensities ( WMH ) lesions on T2 / FLAIR brain MRI are frequently seen in healthy elderly people.
BACKGROUND : Whole body vibration has recently been used as a therapeutic intervention for the treatment of children with disabling conditions.
BACKGROUND : Whole-exome sequencing ( WES ) has been successful in identifying genes that cause familial Parkinson's disease ( PD ) .
BACKGROUND : Whole genome and exome sequencing usually include reads containing mitochondrial DNA ( mtDNA ) .
BACKGROUND : With advancing age comes dramatic increase in the incidence of chronic diseases , disabilities , and mental problems.
BACKGROUND : With aging of the population , the numbers of osteoporotic vertebral fractures with intravertebral cleft have been increasing.
BACKGROUND : With aging , the human fracture risks gradually increase.
BACKGROUND : With aging , the probability of experiencing multiple chronic conditions has increased , along with symptoms associated with these conditions.
BACKGROUND : With aging there is an increase in frailty and chronic disease leading to a potential increase in medication use.
BACKGROUND : With an aging population and limited resources , the incidence and prevalence of chronic kidney disease is increasing.
BACKGROUND : With an aging society and raised expectations , joint replacement surgery is likely to increase significantly in the future.
BACKGROUND : With constrained health-care resources , there is a need to understand barriers to cost-effective medication use.
BACKGROUND : with continued ageing , levels of frailty are an increasing concern.
BACKGROUND : With increasing age neuromuscular deficits ( e.g. , sarcopenia ) may result in impaired physical performance and an increased risk for falls.
BACKGROUND : With increasing age , physical capacity decreases , while the need and time for recovery increases.
BACKGROUND : With increasing age the immune system shows functional decline.
BACKGROUND : With increasing age , the smile becomes elongated and less appealing.
BACKGROUND : With increasing life expectancy , fragility fractures of the pelvic ring ( FFP ) are becoming frequent.
BACKGROUND : With infertility populations in the developed world rapidly aging , treatment of diminished ovarian reserve ( DOR ) assumes increasing clinical importance.
BACKGROUND : With infertility populations rapidly aging , treatments improving pregnancy chances assume increasing clinical importance.
BACKGROUND : With longer lifespan there is a need for maintaining optimal quality of life and health in older age.
BACKGROUND : With population ageing , research is needed into new low-cost , scalable methods of effective promotion of health and wellbeing for older people.
BACKGROUND : With potent antiretroviral drugs , HIV infection is becoming a chronic disease.
BACKGROUND : With rapid expansion of antiretroviral therapy for HIV , there are rising life expectancies among people living with HIV.
BACKGROUND : With the aging of our society , concerns about the quality of nursing homes have been increasing.
BACKGROUND : With the aging of the population comes a greater need for geriatric and gerontology teaching.
BACKGROUND : With the aging of the population in Taiwan , the financial burden of stroke on the healthcare system is expected to rise.
BACKGROUND : With the aging of the population living with HIV , the absolute risk of cardiovascular disease ( CVD ) is increasing.
BACKGROUND : With the aging population and improved cancer care , the number of cancer survivors is steadily increasing.
BACKGROUND : With the aging population , more elderly patients are being considered for hepatic resection.
BACKGROUND : With the increase in life expectancy , the elderly Brazilian population has grown considerably.
BACKGROUND : With the increasing number of aging individuals with cognitive impairments , effective screening measures would improve the likelihood of detection.
BACKGROUND : With the ongoing demographic shift , the quality of life and health promotion among older individuals are becoming increasingly important.
BACKGROUND : With the worldwide growing aging population , the high prevalence of osteoporosis-related fractures is associated with high morbidity and mortality.
BACKGROUND : Women aged ≥65 are generally underrepresented in early breast cancer studies.
BACKGROUND : Women are affected dramatically by urinary incontinence ( UI ) .
BACKGROUND : Women tend to develop more and deeper wrinkles in the perioral region than men.
BACKGROUND : Work-life balance is a priority of EU policies but at the same time demographic change affects the labour market.
BACKGROUND : Worldwide , populations are aging and the health of elderly individuals is deteriorating.
BACKGROUND : Worldwide , the population is aging and the number of individuals diagnosed with dementia is rising rapidly.
BACKGROUND : Worldwide , the rate of aging is highest in Japan , especially the female population.
BACKGROUND : Young adults with familial hypercholesterolemia ( FH ) are at a critical period for establishing behaviors to promote future cardiovascular health.
BACKGROUND : Younger and older generations may differ substantially in their lifetime smoking habits , which may result in generation-specific health challenges.
BACKGROUND : Young females exhibit lower cardiovascular event rates that young men , a pattern which is lost , or even reversed with advancing age.
BACKGROUND : Zanamivir is a neuraminidase ( NA ) inhibitor used for the treatment of influenza.
BACKGROUND : Zebrafish have become a valuable model for the study of developmental biology and human disease , such as cardiovascular disease.
Back muscle strength and thoracic ROM impact on improvement of QOL in the middle-aged and the elderly.
Back pain , as well as non-vertebral and multiple vertebral fractures , were associated with lower HRQoL.
Backward conditional logistic regression analysis was conducted to determine the strongest correlates of measured blood pressure category.
Backwards protective steps occur earlier than forwards ; such promptness may have evolved out of bio-mechanical features which make falling backwards easier.
Backward stepwise logistic regression was used to identify predictors of near-falls.
BACs have recently attracted attention , because several researchers proposed using them as a surrogate marker of arteriosclerosis or osteoporosis.
Bacteria encoding the New Delhi metallo-β-lactamase gene ( blaNDM-1 ) are regarded as superbugs for their resistance to multiple antibiotics.
Bacterial contamination may occur during any of the steps in the farm-to-table continuum from environmental , animal , or human sources and cause foodborne illness.
Bacterial factors like urease , AmiE , AmiF , hydrogenase and arginase are needed for survival in the acidic gastric environment.
Bacterial genotypes were determined by spa typing.
Bacterial growth over the biomaterial and in-depth growth were assessed as well.
Bacterial pneumonia and chronic obstructive pulmonary disease were the two most common incident pulmonary diseases , whereas opportunistic pneumonias were less common.
Bacteria were not found in any of the specimen.
Bacteria were transferred to Sven-Gard agar to test mobility.
Bacteriuria and symptoms remit and recur spontaneously.
B. adolescentis and B. catenulatum groups were predominant after weaning.
BAFME was considered as non-progressive , but cortical tremor worsened in some of the aged patients.
B-age was estimated with an algorithm , based on DNA methylation in @number@ CpGs.
Baicalein also suppressed the activation of NF-κB through PPARγ activation.
Baicalein is widely used in Korean and Chinese herbal medicines as anti-inflammatory and anticancer therapy.
Baicalein treatment on HCT116 cells resulted in a concentration-dependent inhibition of cell growth and induction of apoptotic cell death.
Baicalin can inhibit Aβ-induced microglial cell activation by regulating the JAK2 / STAT3 signaling pathway in AD transgenic mice.
Baicalin has shown multiple neuroprotective biological activities , including antiapoptotic and anti-inflammatory functions in neurodegeneration diseases.
Baicalin protected the neuronal cells from extraneous and endogenous peroxynitrite-induced neurotoxicity.
BAILAMOS is a 4-month program that meets two times per week for one 1h per session.
BAI provides valid estimation of body adiposity in an older adult population ; however , BMI may be a better index for older men.
BA is reflected best by L until start of puberty and by T and L thereafter.
BAI , VAI , and waist-to-hip ratio ( WHR ) were calculated.
Bakuchiol was also formulated into a finished skin care product and was tested in clinical case study by twice-a-day facial application.
Balance and cognitive impairments which are common with aging often coexist , are prognostic of future adverse health events , including fall injuries.
Balance and leg strength were compared using a 2-way analysis of variance with repeated measures.
Balance and strength exercises were prescribed ; @percent@ reported using resistance equipment such as ankle weights and / or exercise band.
Balance assessment forms an important component of fall-prevention programs for older adults.
Balance confidence should be measured regularly in community dwelling older adults using the ABC.
Balance confidence was quantified by the ABC-16 , which includes the ABC-6.
Balance control was characterized using center of pressure measures and showed greater instability for older adults.
Balanced diet or some drugs can limit the deleterious effect of AGE.
Balance disequilibrium is a significant contributor to falls in the elderly.
Balance disorders can have a major functional impact among the elderly.
Balanced nutrition is an essential factor in the elderly.
Balance , functional task performance , fear of falling , and self-reported quality of life were assessed at baseline and after @number@ weeks.
Balance function was evaluated with the Tinetti performance-oriented mobility assessment ( POMA ) , which includes balance and gait subscales.
Balance impairs with aging and may cause mobility limitations and functional decline.
Balance improvements after a short Pilates intervention were maintained @number@ year later in all participants , with increased benefits from ongoing participation.
Balance is influenced by plantar flexor performance as measured by the UHR test.
Balance performance was evaluated by computing an Equilibrium Score ( ES ) and anterior-posterior sway path length ( APPlength ) .
Balance performance was re-evaluated after ∼20 months.
Balance Post was divided into 10s intervals.
Balance testing and structural magnetic resonance imaging were performed before and after @number@ @number@ and @number@ training weeks.
Balance training resulted in performance improvements in both groups.
Balance was assessed after admission and @number@ weeks later on a force platform at floor level and simultaneously by a tri-axial accelerometer at hip level.
Balance was evaluated by computerized posturography.
Balance with the gesturing limb to the rear increases the age and vision effect compared to balances with the limb forward or to the side.
BAL fluid from EPPE animals exhibited early accumulation of both SP-D and S-nitrosylated SP-D.
BAL fluid from patients with HPS1 exhibited similar changes in SP-D that correlated inversely with pulmonary function.
BALF percentage of neutrophils positively correlated with age.
B-ALLs generated from 12- and 20-month-old progenitors gave rise to a more invasive B-ALL than the one developed from 4-month old precursors.
BAL performance is virtually independent of platelet counts.
B and C showed lower mTBS than A after aging ( P < @number@ ) .
Band @number@ is altered primarily by oxidation , which in turn generates SCA.
Band @number@ isoforms are ubiquitous : they have been found in all mammalian cells and species so far examined.
Bang and Tsiatis adjusted healthcare costs and resource use were compared using bootstrap p-values and @percent@ CI.
B. animalis ssp. lactis was detected in @percent@ of the subjects and their ages were restricted.
BA occlusion-mediated constriction ( OMC ) was significantly attenuated with IPC treatment ( -43±13% to -33±12% , p = 0.003 ) .
BA plots demonstrated acceptable agreement for cephalometric measurements.
Barbiturates were more frequent in the elderly , while antidepressants were more frequent in younger adults.
Barcas provides three functions for quality control ( QC ) of a barcode library and distinguishes erroneous barcodes from PCR or sequencing errors.
BARC showed a significantly higher mean value than the other groups ( P < @number@ ) .
Barium also dampened fizziness but did not influence burning-stinging sensation.
Barium solutions can be considered to elicit behaviors that are similar to those used with nonbarium liquids outside the assessment situation.
Barnes ' award citation , biography , and a selected bibliography are presented here.
Baroreflex sensitivity ( BRS ) by measuring pulse intervals and blood pressure has been proven as an effective indicator.
Baroreflex sensitivity was reduced , whereas dynamic cerebral autoregulation gain was elevated at rest in older adults.
Barrel-fermented wines generally presented @number@.2-fold higher total phenolics , whereas tank-fermented wines exhibited @number@.1- and @number@.2-fold greater total proanthocyanidin and anthocyanin contents , respectively.
Barrel-fermented wines were preferred in the mouth , whereas olfactory preference depended on barrel toasting.
Barriers described include language , time , not wanting to burden their adult children , and transportation.
Barriers included carer mental health literacy , consumer and carer readiness for services , and worker misinterpretation of confidentiality and privacy laws.
Barriers included limited time and resources , especially for senior centers and supportive housing.
Barriers of PT included dementia diagnosis and French as a first language.
Barriers on the intra- and interpersonal level were of less influence.
Barriers to accessing mental health services included difficulties obtaining health insurance , finding a mental health provider , scheduling appointments , and transportation.
Barriers to implementation of an intensive activities-focused intervention in rural communities are discussed.
Barriers to improved performance were sought from all groups through focus group analysis.
Barriers to OT included dementia diagnosis.
Barriers to outdoor physical activity and unmet physical activity need were enquired with a questionnaire.
Barriers to recruitment and retention of faculty must be considered and addressed to sustain this teaching model.
Barriers to treatment amplify the challenges of ageing for the transgender person and can lead to nondisclosure of clinically relevant personal information.
Barriers to treatment were identified and recommendations were made to reduce mental health disparity in this elderly population.
Barriers were described as not having access to a midwife , no funding , no insurance and lack of clinical privileging for midwives.
Barthel Index score in @number@ patients was > 60 and the score was @number@ ± @number@ pre-operatively.
Barthel score was reassessed at @number@ months.
Barthel ' s Index was used to evaluate functional status.
Basal and insulin-stimulated FOXO3A mRNA expression was assessed in skeletal muscle biopsies from the twin population.
Basal autophagy is atheroprotective during early atherosclerosis but becomes dysfunctional in advanced atherosclerotic plaques.
Basal autophagy plays an essential role in the maintenance of cellular homeostasis whereas excessive autophagy may lead to autophagic cell death.
Basal cell carcinoma ( BCC ) , the most common human cancer , results from aberrant activation of the Hedgehog signaling pathway.
Basal cells are precursor cells that differentiate into mature taste cells.
Basal cyclooxygenase ( COX ) -2 RNA levels were very high in the fibroblasts of all patients.
Basal ganglia hemorrhage accounts for approximately @percent@ of all hemorrhagic strokes.
Basal ganglia IDs ( median = 35 , IQR = 159.5 mm3 ) , were found in @percent@ of the sample.
Basal layer cells in stratified epithelia express the reverse transcriptase known as telomerase.
Basal levels of autophagy are required for the maintenance of organellar quality control.
Basal-like breast cancer had a higher pCR statistically.
Basal production and transient increases during stress of glucocorticoids and its hypothalamic regulators are essential for neuronal plasticity and normal brain function.
Base case BCR of Model @number@ tele-homecare was @number@ while Model @number@ was @number@
Based in the mitogenic and neurotrophic activities of PGRN , we hypothesized that PGRN deficit may induce cell cycle disturbances and alterations in neuronal vulnerability.
Based on agreements with participants , external researchers should request access to data via collaborations with the study group.
Based on a high-density electroencephalographic measurement one year after training , we calculated graph-theoretical measures representing the efficiency of functional brain networks.
Based on a literature review , seven parameters were inductively developed.
Based on a multiple case study , the objective was to assess the capacity of municipal administration to provide healthcare for the elderly.
Based on analyzing TTD group A patient derived cells it was initially thought that TTDA has only a NER-stimulating role.
Based on a phylogenetic analysis of TIM sequences , we propose the conservation of this mechanism for mammalian TIMs.
Based on a questionnaire , the seafarers ' attitudes and sun protection were evaluated.
Based on a self-administered questionnaire , the FA index allows easy screening of elderly persons for declining functional competence.
Based on available data , the reference values ( criteria ) for the definition of sarcopenia in elderly Chinese were explored.
Based on big-data analyses , a collection of @number@ important pro-metastatic genes was studied.
Based on bivariate twin modeling , variation in subcortical MD appears to be both genetically and environmentally unrelated to individual differences in subcortical volume.
Based on both experimental and clinical studies , this susceptibility is thought to be due to declining immune responses.
Based on Braak staging of NFTs , NFTs are first observed in the entorhinal cortex.
Based on cloning studies in mammals , all adult human cells theoretically contain DNA that is capable of creating a whole new person.
Based on data reported in the literature and our own experience triamcinolone injections during ritonavir-based therapy should be avoided.
Based on ethnographic fieldwork , we examine how local narratives of stress and self-care intertwine with social responsibilities of older HIV-positive people.
Based on evidence from past laboratory experiments , researchers concluded that this ability decreases throughout adulthood.
Based on four selection criteria @number@ movies were included.
Based on genotype , patients could be correctly , sub- , or supratherapeutically dosed.
Based on GLOBOCAN estimates , about @number@ million new cancer cases and @number@ million deaths occurred in @number@ worldwide.
Based on heart rate variability analysis , only LL kept parasympathetic indexes lower than CON at @number@ min recovery.
Based on human ENCODE data , these sites are targeted by polycomb proteins , including EZH2.
Based on individual trials , we obtained the delta lactate-% validated critical intensity relationship and thereafter an estimate of critical intensity was computed.
Based on international data , PD prevalence was @number@ times higher than expected ; AD prevalence was as expected.
Based on limited data , extensive resection appears to be more beneficial than biopsy.
Based on MISIdiff , the high conflict case was judged to be of significantly greater MM severity than was the low conflict case.
Based on molecular modeling and subsequent biochemical investigations , we identified FAHD1 as a eukaryotic ODx enzyme.
Based on mortality data collected in @number@ the sample was divided into two groups of participants surviving more than @number@ years or not.
Based on mounting evidence , we propose that rejuvenating effects of systemic manipulations are mediated , in part , by blood-borne ' pro-youthful ' factors.
Based on multivariate analyses , only BW had a significant effect on BMD ( β = 0.342 , P = 0.003 ) .
Based on our discussion we propose that TREM2 is a potential therapeutic target for stopping ordelaying progression of AD.
Based on our findings , we propose that the proofreading activity restricts the strand displacement activity of Polδ in MMR.
Based on our findings , we strongly recommend against using the structural images obtained during simultaneous EEG-MRI recordings for further anatomical data analysis.
Based on our findings we suggest occupation of greater complexity is associated with better cognitive performance in women later in life.
Based on our observations it seems unlikely that limited ovarian reserve is a predominated problem in adolescent SGA.
Based on our recent research , we describe a novel approach for the assessment of the lower leg muscle-bone unit in health and disease.
Based on our results , postoperative medical treatment may be individualized according to the patient's age at the time of surgery.
Based on our results , we suggest that men tend to show higher social face sensitivity , while women show more appearance management behavior.
Based on our sample , the younger the patient , the more likely low back pain is discogenic in origin.
Based on pathology , four different macroscopic types and at least two major histological types , intestinal and diffuse , have been described.
Based on polysomnographic recordings ( PSGs ) , it could be shown that the network changes with the sleep stage.
Based on previous somatosensory evoked potential studies , the amplitude of N20 typically increases with age probably due to cortical disinhibition.
Based on pseudo-cohort analysis of Family Expenditures Survey , it compares spending patterns on clothing , cosmetics and hairdressing , 1961-2011.
Based on reaction time data of @number@ Caucasians participating in different cognitive tasks , slower responses characterized the group with the 7-repeat allele.
Based on recent estimates , @percent@ of community-dwelling older individuals are frail and another @percent@ are prefrail.
Based on research demonstrating age-accompanied deficits in executive functioning , we expected to observe increases in unintentional mind wandering with increasing age.
Based on results from the questionnaire , the group was split into low and high memory self-efficacy believers.
Based on SDH , the maximal oxygen consumption supported by a capillary did not differ significantly between young and old people.
Based on sequence homologies to Cg1458 , we recently identified human FAH domain containing protein-1 ( FAHD1 ) as the first eukaryotic oxaloacetate decarboxylase.
Based on serum creatinine levels , glomerular filtration rate ( GFR ) was estimated.
Based on stable integration of recombinant DNA into a host genome , transgenic technology has become an important genetic engineering methodology.
Based on successful experiments in mouse AD models , active immunization with Aβ42 peptide and passive immunizations with anti-Aβ42 antibodies were started in clinical trials.
Based on the assumption that mandibular and somatic growth both follow a parallel line , a CF was postulated and checked for validity and reliability.
Based on the availability of more recent data , this review is primarily focused on countries that are in advanced nutrition transition.
Based on the best available evidence , the Clinical Working Group also formulated general recommendations about clinical management that apply to any patient with CKDnT.
Based on the clinical data obtained from @number@ @number@ patient charts , @number@ out of @number@ diabetes measures were significantly improved.
Based on the cognitive reserve hypothesis , evidence from epidemiological studies shows that low education and cognitive inactivity constitute major risk factors for dementia.
Based on the current evidence concerning these factors , no definitive dietary recommendations are possible.
Based on the current state of evidence , modern procedures to cryopreserve oocytes should no longer be considered experimental.
Based on the data presented here , it is important to consider the toxicity of cationic liposomes during administration in the body.
Based on the data , we hypothesized that TRF may reverse the myoblasts aging through replenishing the regenerative capacity of the cells.
Based on the estimates from NHANES , @percent@ of the population has a VCDR or VCDRA > 97.5th percentile in either eye or OU.
Based on the final model , dosing guidelines are proposed from preterm neonates to adolescents resulting in similar exposure across all age ranges.
Based on the findings , a habitational model for exploring the appropriate space for ageing is formulated.
Based on the findings and their related mechanisms , further studies should design more effective and specific training tasks.
Based on the frontal asymmetry model , an increase in the alpha-1 activation ( p < 0.05 ) might be associated with approach-related emotions.
Based on the Gass-Blodi staging of this disease , all ( @number@ ) were determined to be in stages @number@ and @number@
Based on the human results , we assessed histology and gene expression in the lungs of Sox5 ( - / - ) mice.
Based on the images obtained , spino-pelvic parameters were calculated using Jackson's method so as to analyze any correlations with age.
Based on the International League Against Epilepsy Classification , @number@ patients had FCD Type I and @number@ subjects had FCD Type II.
Based on their cognitive scores , participants were divided into good and poor performers.
Based on their protection mechanism , the active molecules in sunscreens are broadly divided into inorganic and organic agents.
Based on their structure and interactions , Nesprins integrate the nucleus into the cytoskeleton of a cell.
Based on their unique identification number , we described the next hospitalizations occurring in 2009-2011 whatever the causes.
Based on the life stress paradigm , we predicted that higher levels of stress would allow APOE to influence positive and negative affect.
Based on the pairwise FasL analysis , FasL concentration is likely to be genetically controlled.
Based on the path analysis , the hypothesized framework fit the sample data.
Based on the pattern of the presence of gray hair in different body sites , six stages of gray hair were computed.
Based on the prior criteria , a final selection of @number@ articles was used for the present manuscript.
Based on the proposal presented here , the construction of a protocol for the process of recognizing and identifying an individual can be implemented computationally.
Based on the qPCR data , administration of betaine inhibited inflammatory cytokines such TNF-α , IL-6 , iNOS and COX-2.
Based on the reported data , we infer that the association of Gluc and PDRN has a potential application in cartilage therapy.
Based on the results of our analyses of variables affecting prevMM , we make some design recommendations.
Based on the results of our study , the new-lift is a very effective surgery for rejuvenation of the face with mild to moderate aging.
Based on the results of this study , maternal age is a critical factor for embryonic early-cleavage in agonist protocol but not in antagonist protocol.
Based on these clinicopathological features , we proposed a diagnosis flow chart of adult-onset NIID.
Based on these empirical data , the concept of facial aesthetic unit separation appears to play a significant role in perceived facial aging.
Based on these findings , we discussed the implications and future research directions.
Based on these findings , we hypothesized that the higher transgene expression observed in the denervated striatum may be a function of increased gliosis.
Based on these findings , we hypothesized that Tnmd might be an important factor in the functional performance of tendons.
Based on these insights , it presents a list of propositions to be tested in further research.
Based on these interviews a personal advice was written.
Based on these models , we extracted predicted current intensity from @number@ representative structures in the brain.
Based on these naturalistic data , age alone should not be considered a contraindication or poor prognostic indicator of the antidepressant efficacy of TMS.
Based on the sensitivity and consistency of the estimated thresholds , the PAS quantifies the likelihood that proprioception is intact.
Based on these observations , a malignant renal tumor was diagnosed and laparoscopic left nephrectomy was performed.
Based on these parameters a 0-2 score was developed.
Based on these premises , we investigated the differences and similarities in spermidine and resveratrol-induced autophagy.
Based on these recent findings , we now advance the hypothesis that CD36 via DM insulin-associated pathways is closely involved in TBI chronic pathology.
Based on these results , a taxonomy of social activities is proposed.
Based on these results , the present study then aimed to investigate the underlying mechanisms.
Based on these results , VASH2 may be a promising molecular target for ovarian cancer treatment.
Based on these results , we applied our method to DNA methylation data from human blood from individuals of various ages.
Based on these results , we believe that relative high p53 facilitates NP cell viability and integrity.
Based on these results we generated a mice-to-human age map which is publicly available.
Based on these results we propose a model of IGF1-based regulation of bone fracture.
Based on these results we speculate that a \ "common mechanism \ " may underlie age-of-onset across several neurological diseases.
Based on these results , we suggest that the deregulation of HIF-1alpha is associated with UVB-induced hyperplasia of the epidermis.
Based on these studies , GDF @number@ is a promising candidate to serve as a novel biomarker of diseases.
Based on these , three latent classes of cognitive performance profiles ( LC1 to LC3 ) were identified among the older adults.
Based on the severity of cognitive impairment , it is possible to determine the primary and secondary preventative measures for cognitive frailty.
Based on these well-known risk factors , for many years , intervention and primary prevention strategies have focused on modifying lifestyle factors in adulthood.
Based on the size of the PCR products using TRYP1 , @percent@ were positive for T. lewisi and 1·0% positive for Trypanozoon.
Based on the spectrofluorescence study , the alterations in metoprolol binding affinity to the specific sites that increase the toxicity of the drug were investigated.
Based on the structure , we identified amino acids important for the TPR-BEN domain interaction , and for the functional interaction of the full-length proteins.
Based on the translucency properties of human enamel and dentine , those of replacing restorative materials should be optimized for successful esthetic rehabilitation.
Based on this analysis , we formulated an epigenetic-aging model in mice using the liver methylomes of @number@ mice from @number@ to @number@ months old.
Based on this analysis , we will present the issues which seemed to be specific in the psychological support of young adults and their relatives.
Based on this assumption , several known oxidants and antioxidants have been studied in patients with NPs.
Based on this cumulative knowledge , the beneficial biological effects of hydrogen have been confirmed.
Based on this evidence , this narrative review discusses the pharmacological management of osteoporosis in the oldest old ( ≥80 years ) .
Based on this finding , NAM is hypothesized to affect cellular senescence progression by keeping ROS accumulation low.
Based on this hypothesis the influence of intelligence on cognitive efforts to self-regulate somatic phenomena is amenable to systematic testing.
Based on this literature , we propose a conceptual model for delirium.
Based on this model , we generated cognitive charts designed to optimize accuracy for distinguishing participants with dementia from healthy controls.
Based on this progress , essential therapy for cure of AD is urgently expected.
Based on this , recommendations on how to infuse and advance gerontological nursing education in SA are provided.
Based on this vessel wall immaturity and increased susceptibility to dilation , different diagnostic and therapeutic approaches are warranted.
Based on this , we can conclude that founded karyotype's hanges do not lead to transformation and immortalization of cells in vitro.
Based on this , we performed followed by qRT-PCR and confirmed that NR2F1 directly binds and regulates both miR-140 and Klf9 in vivo.
Based on this , we suggested that SPP1 expression may reflect the functional or structural specialization of highly developed corticospinal systems.
Based on those epidemiological data and basic research , it was recently proposed that AD can be considered as \ "type @number@ diabetes \ ".
Based on two contrasting case studies , this article illustrates the importance of collaborative partnership for the success of AFC implementation.
Based on unpublished in-house comprehensive consumer clinical studies , it is believed salicin may have anti-aging capabilities when applied topically to human skin.
Based on urodynamic findings and symptoms , UAB can be classified into @number@ types ( DU , AcD , and DHIC ) .
Based upon our findings , we are able to elaborate on how to further enable demand-based provision of long-term care by means of modularity.
Based upon stress and coping theory , this study examined whether perceived family support protects the impact of negative emotional experience with dyslexia on self-esteem.
Based upon the identified landmarks a two-dimensional classification was developed.
Based upon the indigenous Japanese WRN loss-of-function mutation heterozygote rate of @number@ per @number@ we speculate the possibility of approximately @number@ heterozygotes in Hawaii.
Base excision repair ( BER ) is the major pathway for repairing oxidative damage events in chromosomal and mitochondrial DNA.
Base excision repair remains the best characterized.
Baseline ( 24-month-old ) mice were randomized to receive @number@ weeks of SS-31 , or saline , and killed at @number@ months of age.
Baseline , 2-year , 6-year , and 8-year visits occurred between @number@ and @number@
Baseline AFM values were used as the covariate.
Baseline alcohol consumption was associated with slower decline in attention , language , and memory.
Baseline ambulatory blood pressure or the night / day systolic or diastolic ambulatory blood pressure ratios were not associated with GFR decline.
Baseline analyses showed an independent negative association between PWV and muscle parameters after adjusting for confounders in both genders.
Baseline analyses showed no significant racial / ethnic differences in the probability or number of falls.
Baseline and 1-year MRIs were registered , and brain , hippocampal , and ventricular volumes and annualized volume changes were calculated.
Baseline and change in BP were significant predictors of higher WML progression over time after controlling for potential confounders.
Baseline and follow-up assessments included a face-to-face interview and a battery of performance tests.
Baseline and follow-up performance data across a range of clinical and systems-based measures were compared in aggregate.
Baseline and perioperative data were comparable for both approaches.
Baseline and postprocedural changes in vital signs were analyzed.
Baseline and subsequent evaluation included Mini Mental Status Examination and five other neuropsychological tests that load on cognitive domains known to decline in PD.
Baseline Aβ1-42 level was strongly correlated with rate of brain atrophy only in the NC-low group ( p < @number@ ) .
Baseline best-corrected VA was not associated with DS change ( r = @number@ p = @number@ ) .
Baseline brachial artery measures were a 10-s average before ( preocclusion ) , during ( occlusion ) and after ( postocclusion ) hyperaemia.
Baseline cardiovascular risk factors were compared according to the development of MCI or dementia during the study period.
Baseline CARG GA was successfully completed by all subjects but one.
Baseline characteristics , clinics , isolates , rate of transfer to ICU , MEWS was collected on admission according to the study protocol.
Baseline characteristics , CV risk factors , and AC scores were similar between treatment groups.
Baseline characteristics included age , sex , Charlson comorbidity index ( CCI ) , diagnosis , and interventions ( ERCP or cholecystostomy ) at V1.
Baseline characteristics of both groups were compared.
Baseline characteristics were collected.
Baseline characteristics were compared between subjects with and without one or more falls.
Baseline characteristics were not different between genders.
Baseline characteristics were similar between both cohorts.
Baseline characteristics were similar between the two groups.
Baseline characteristics were used to derive the risk score ( RS ) to reflect individual's baseline pre-widowhood vulnerability.
Baseline clinical and demographic variables , PD medications , neuroimaging , and genetic variables were evaluated as potential predictors of CSF biomarker changes.
Baseline clinical and non-invasive cardiac and respiratory investigations were obtained from @number@ DM1 patients , who were regularly re-examined.
Baseline cognitive function was correlated with changes in dietary quality.
Baseline cognitive performance was lower in older individuals , in males , those with lower education / occupation , and those on the amyloid pathway.
Baseline comorbidities were similar between groups except for renal disease.
Baseline covariates were smoking , alcohol , sex , and income.
Baseline CPCs were measured in @number@ patients based on the cell surface markers CD34 , CD133 , and aldehyde dehydrogenase ( ALDH ) activity.
Baseline CRP levels were not predictive of the rate of change in FEV1 or FVC over time.
Baseline CSF Apo-E levels did not predict longitudinal CSF Aβ or tau changes.
Baseline data for the present study were collected in 1991-93.
Baseline data from the Boston Puerto Rican Health Study were analyzed , which included @number@ adults aged 45-75 years.
Baseline data were collected between @date@ and @date@ and respondents were followed until @date@ ( follow-up range : 0-5 years ) .
Baseline data were collected for @number@ @number@ participants , aged from @number@ months to @number@ years.
Baseline data were collected prospectively.
Baseline data were obtained in @number@ untreated hypertensive patients.
Baseline demographic variables were recorded.
Baseline dietary data were collected between @number@ and @number@ using a validated food frequency questionnaire.
Baseline diffusion-weighted imaging volume and final infarct volume were analyzed using semiautomated volumetric method.
Baseline dispositional optimism was assessed using a four-item questionnaire.
Baseline distress levels did not predict adherence.
Baseline DQ alone was not associated with MS maintenance.
Baseline DQ was calculated from @number@ non-consecutive 24-hour dietary recalls collected at T1 using the validated Canadian Healthy Eating Index ( C-HEI ) .
Baseline DS was associated with best-corrected VA change ( r = @number@ p = @number@ ) .
Baseline estimated glomerular filtration rate was the only one predictor of dialysis dependency identified.
Baseline F2-isoprostane levels were significantly lower at IRX compared to IRC ( P < @number@ ) and not different between groups.
Baseline factors independently predicting cholecystectomy were identified.
Baseline fasting glucose was assessed as part of the screening exam , and baseline HbA1c was determined centrally by standardized methods.
Baseline FA was used as a predictor variable , whereas gray and white matter atrophy rates as indexed by Tensor-based morphometry were the dependent variables.
Baseline galactomannan ( OR @number@ 95%CI : @date@ @number@ ) and lesion volume ( OR @number@ 95%CI : @number@.73- @time@ ) were predictive of death.
Baseline GSIS scores significantly predicted suicide ideation at a 2 + year follow-up assessment.
Baseline hazardous alcohol use was reported by @number@ ( @percent@ ) .
Baseline interview included questions about functional disability , psychiatric history , independent living status , social interactions , and cognitive function.
Baseline interviews were done in the community and care homes.
Baseline IOP ( mm Hg ) was @number@ ± @number@ @number@ ± @number@ and @number@ ± @number@ in groups @number@ to @number@ respectively.
Baseline job characteristics were defined by the Swedish version of the Karasek demand / control model.
Baseline J point amplitude ( JPA ) was obtained from continuous surface electrocardiograms.
Baseline life-space mobility was assessed during in-home interviews.
Baseline LSA scores before admission were measured during an index hospitalization ; follow-up LSA scores were determined over the telephone at @number@ days.
Baseline magnetic resonance imaging ( MRI ) was used to evaluate brain morphology.
Baseline measures of these biomarkers partially mediate excess mortality risk among HIV + versus uninfected people.
Baseline MOF and HF probabilities were estimated using FRAX before and after applying the TBS adjustment.
Baseline multidimensional assessment included demographics , Mini Mental State Examination ( MMSE ) , Barthel Index and Neuropsychiatry Inventory ( NPI ) for all patients.
Baseline National Institutes of Health Stroke Scale score was @number@
Baseline neural factors , such as properties of brain networks , may predict training outcomes and can be used to improve the effectiveness of interventions.
Baseline @number@.4-g monofilament detection predicted a greater decline in muscle power / kg.
Baseline observations of affect were performed for comparisons.
Baseline pBDNF was higher in patients with moderate AD ( but not mild AD ) than in healthy controls.
Baseline PGI-M was lower in the RAL arm ( P = @number@ ) ; no other between-arm cross-sectional differences were observed.
Baseline physical function examination included grip strength , comfortable gait speed , and sway area with eyes open.
Baseline plasma samples drawn at enrollment were analyzed for pro-SFTPB using ELISA to detect differences in protein expression levels for cases and controls.
Baseline predictive values of all aforementioned indices were then compared using survival analysis on @number@ MCI subjects.
Baseline remission status predicted having more total contacts at follow-up.
Baseline RHR was non-linearly associated with HF risk.
Baseline RMR and multimorbidity were positively associated , independent of covariates ( p = @number@ ) .
Baseline score was consistently the single greatest predictor of visit @number@ score.
Baseline self-reported physical function correlated with the Short Form-12 physical subscale ( ρ = @number@ p < @number@ ) , and predicted survival.
Baseline serum 25OHD was not associated with intramuscular IL-6 or TNFα gene expression or protein concentration.
Baseline serum free T₄ levels were not significantly different between these two groups.
Baseline serum level of leptin was assessed by radioimmunoassay and interleukin ( IL ) -6 by a chemiluminescent immunoassay in the first @number@ subjects.
Baseline serum levels of CML-AGE , sRAGE , glucose and insulin were determined.
Baseline sex associated differences were retained over time , but no sex differences in rate of decline were found for any measure in either cohort.
Baseline sociodemographic , health , and chronic disease measures were included as covariates in analyses.
Baseline somatosensory evoked potentials ( SSEP ) , spinal magnetic resonance imaging ( MRI ) and urodynamics were assessed before and after treatment.
Baseline test score , age , education , and race were robust predictors of follow-up test scores across most tests.
Baseline VA levels correlated with baseline DS levels ( r = @number@ p < @number@ ) .
Baseline values for social effects of skin appearance , health status , and self-esteem were significantly different between PM and NM volunteers.
Baseline volumes analysis revealed that FCSRT and IST declines were both associated with lower volumes of the medial temporal region.
Baseline weight , CD4 cell count status , and hemoglobin level were strongly associated with weight gain.
Baseline white matter microstructure as indexed by DTI was associated with some of the observed regional volume loss.
Basic ADLs ( BADLs ) were defined as : eating , walking , toileting , bathing , and grooming.
Basically , support and encouragement are required.
Basically these two studies recruited similar patients with ≥60% stenosis based on carotid duplex.
Basically , this subretinal active implant transforms the incoming light into electric pulses to stimulate the remaining cells of the retina.
Basic functional mobility ( Timed Up and Go Test [ TUG ] ) and SF36 health status were also measured.
Basic group had the quantity CD8 + deficit ( @percent@ ) .
Basic information ( age , height and weight ) , and vBMD of the mandible ( middle , body and angle ) were recorded.
Basic laboratory showed that approximately @percent@ of subjects had normal values , using standard benchmarks established for an adult population.
Basic molecular mechanisms , associated with the main cell population of the dermis - fibroblasts - are the basis of skin aging.
Basic neuropsychological and psychiatric measures were administered to all participants.
Basic parameters of the naive antigen ( Ag ) -specific T-cell repertoire in humans remain poorly defined.
Basic physical performances and gait performances ( normal gait , fast gait , or dual-task gait ) were measured.
Basic research has suggested a number of potential mechanisms of action of cranberry bioactives , although further molecular studies are necessary.
Basic research on neurocognitive aging has traditionally adopted a reductionist approach in the search for the basis of cognitive preservation versus decline.
Basic research suggests that insulin accelerates Alzheimer-related pathology through its effects on the amyloid beta ( Abeta ) .
Basic scientists demonstrated that the multiple neuroprotective effects of estrogen on brain cells may induce a differential biological response according to the time of treatment.
Basic sociodemographic and clinical data including QOL were collected.
Basic sociodemographic factors and previously known risk factors for DED were included in the analyses.
Basic studies on the physiological functions of HE and on the chemical identification of its active ingredients have progressed in recent decades.
Basic testing was less likely to be complete in PC.
BASIGIN / CD147 / EMMPRIN is a multifunctional transmembrane glycoprotein strongly expressed in tumours.
BASIGIN controls tumour metabolism , particularly glycolysis by facilitating lactic acid export through the two monocarboxylate transporters MCT1 and hypoxia-inducible MCT4.
Basilar artery ( BA ) flow was significantly decreased in individuals with one or both fetal posterior cerebral arteries ( PCAs ) .
Basing on relevant manuscripts , this short review about the anatomy , embryology and anthropology of the mandible and the mandibular foramen was written.
Basolateral secretion was fully established by week @number@ in non-AGEd conditions.
Basophil and eosinophil counts also increased with increasing BMI but not significantly.
Bathing was of borderline significance ( p = .09 ) .
BAX mediated the release of mitochondrial cytochrome c , activation of caspase-3 and cell death partially through the lysosome-cathepsin B-tBid pathway.
BAX was degraded by autophagy under basal conditions ; however , its degradation was inhibited when DRAM1 expression was induced.
BAY alone increased IL1β expression by 3-fold.
Bayesian LCA provided a powerful tool to explore cognitive typologies among healthy cognitive agers.
Bayesian methods , combined with MI , are useful in handling these issues.
Bayley Infant Neurodevelopment Screener - BINS ( Aylward , @number@ ) is a low cost , fast instrument.
BBAR was also appointed as the pathology core of Japanese Alzheimer Disease Neuroimage Initiative ( JADNI ) this year.
B. bifidum was detected at almost all ages.
B. breve was detected in approximately @percent@ of children under @number@ years old.
BBs are only relatively contraindicated in asthma , but not in COPD.
BCAA catabolism is a conserved regulator of physiological aging and participates in diverse physiological and pathological processes , including carcinoma development.
BCAT1 can promote mitochondrial biogenesis , ATP production and repress mitochondrial ROS in breast cancer cells by regulating the expression of related genes.
Bcl-3 could bind to Smad3 and prevent the ubiquitination and degradation of Smad3 protein.
Bcl-3 deletion inhibited the migration and invasion of breast cancer cells in vitro , as well as breast cancer lung metastasis in vivo.
Bcl-3 expression was significantly associated with metastasis-free survival in breast cancer patients.
Bcl-3 knockdown enhanced the degradation of Smad3 but not Smad2 following TGFβ treatment.
Bcl-3 was required for the expression of downstream TGFβ signaling genes that are involved in breast cancer lung metastasis.
Bcl-x BACKGROUND : Depression prevalence in older adults varies largely across studies , which probably reflects methodological rather than true differences.
BCM summaries were tested to determine if any was a good predictor of BMI after age @number@
BCM was calculated from TBK by using this formula : BCM ( kg ) = @number@ × TBK ( mmol ) .
BC-TEOAEs were measured binaurally in ten normal hearing adults and in ten infants.
BC was assessed using a General Electric Lunar DXA IQ machine.
BC was not associated with MCI in men or women.
BCX significantly reduced the multiplicity of the NNK-induced lung tumor by @percent@ to @percent@ compared with the NNK-treated mice without BCX supplementation.
BCX supplementation was given daily to the mice starting @number@ weeks prior to the injection of NNK and continued @number@ weeks after NNK injection.
BD has been associated with decreased mitochondrial electron transport chain activity and increased oxidative stress.
BDNF is known to regulate SST expression ; however , the mechanisms underlying decreased expression of both genes are not understood.
BDNF is present in both the gray and white matters of the brain.
BDNF levels were lower in the frontal cortex of apoE4 mice and higher in the hippocampus of exposed mice , independent of the genotype.
BDNF levels were measured at baseline ( T0 ) and after @number@ months ( T2 ) of escitalopram.
BDNF ( @number@ ) Met carriers with higher HbA1c levels evidenced slope decline in episodic recall.
BDNF plasma levels were assessed by ELISAs.
BDNF promoter methylation could be a proxy biomarker for depression late in life.
BDNF secretion is influenced by epigenetic ( DNA promoter methylation ) and genetic ( val66met polymorphism ) profiles.
BDNF , serotonin , and dopamine were low in higher age group.
BDNF serum levels were evaluated through ELISA method.
Beat-to-beat HRR to standing was monitored over a 2-minute time horizon using a finometer.
Beat-to-beat RR and QT interval time series were automatically extracted.
Because ADHD differences were not evident , the effects either were not present or were smaller than that of difficulty level and age.
Because age can affect the progression of HIV infection , we aimed to evaluate the present knowledge on HIV infection in older patients.
Because age was included as a covariate in all analyses , the puberty effect cannot be accounted for by age.
Because aging is a potent determinant of plasma BNP levels , BNP may be related not only to fat mass but also to muscle mass.
Because aging is associated with changes in emotional response to smells , we also examined how aging affects the relationship between olfaction and nutrition.
Because aging is associated with elevated risk for ischemic cardiovascular disease and exercise intolerance , interventions that target erythrocyte-mediated ATP release may offer therapeutic potential.
Because alcohol-related diagnoses ( ARD ) appeared to have a disproportional effect , we further stratified our calculations by ARD history.
Because aortic stiffness depends on the prevailing blood pressure , effective antihypertensive treatment is expected to reduce it in proportion to the blood pressure reduction.
Because both concentrations could be obtained simultaneously from the same laboratory assay , use of both metrics is warranted to better understand PLFA-disease relationships.
Because both isoforms are found in human B cells , we compared their functions in transduced murine B and human pre-B cells.
Because both SNPs are located in the @number@ untranslated region of FOXO3A , they could be of functional relevance for the longevity phenotype.
Because both studies require organ donation , ascertainment of mortality was complete and dates of death accurate.
Because cardiovascular risk is modifiable , effective treatment of related comorbidities may improve morbidity and mortality in HIV-infected patients.
Because cartilage is mechanically sensitive , these loading changes can initiate a catabolic effect , culminating in tissue degeneration.
Because central BP is strongly linearly associated with age , it can be regarded as an integrated marker for vascular aging.
Because chromosomal translocation is not readily detected by G banding , the FISH method is essential.
Because CLU and CR1 had already been analyzed in these populations , we restricted our investigation to BIN1 , EXO2CL3 , and PICALM.
Because cognitive functioning is associated with community outcomes , these findings suggest a need for treatments targeting cognitive symptoms across the life span.
Because corticotropin-releasing factor ( CRF ) receptors are implicated , we compared CRF receptor binding in pre- and postpubertal rats.
Because CVD poses an important health risk , further elucidation of the role of serum PTH in CVD and arteriosclerosis is relevant.
Because dementia patients have a diminished capacity to communicate discomfort , untreated pain may be expressed in the form of behavioral and psychiatric symptoms.
Because different emotions are conveyed by different parts of the face , changes in visual scanning patterns may account for age-related variability.
Because early detection of AD has become increasingly important , promoting demand for screening tests with adequate sensitivity.
Because effects of developmental factors might be region-specific , the sensitivity of each ROI to contributions of each factor is explicitly modelled.
Because elderly patients fall easily into dehydration , normal values for IVC diameters in elderly patients may be helpful for geriatric medicine.
Because elderly patients have more co-morbidities and decreased life expectancy , the benefit of these procedures must be critically evaluated in such patients.
Because falls are the result of various factors , the guidelines include a multidimensional assessment and multimodal strategy.
Because FFA receptors exhibit a high level of homology , our observations could be applicable to other members of this family.
Because functional alterations of this region are currently described in Alzheimer's disease , this functional signature could constitute a risk for Alzheimer's disease.
Because gait and postural disturbances are so common , the clinical classification should be clear , straightforward , and simple to use.
Because gene expression changes are critical in both normal development and disease progression , epigenetics is widely applicable to many aspects of biological research.
Because hepatic clearance through NQO2 does not mature until teenage years , compounds detoxified by this enzyme may be more deleterious in children.
Because hypoxia occurs widely in solid tumors , where it provokes drug resistance , we investigated the involvement of SIRT1 in hypoxia-induced chemoresistance.
Because IGFBP2 is an adipokine , an altered production from visceral WAT depots could impact on IGF-1 signaling and its downstream targets.
Because IL-6 release has been associated with obesity , differences in body mass index ( BMI ) were taken into consideration.
Because institutionalization costs are high , more research is needed to investigate predictors of preventing institutionalization.
Because it obviously underwent a natural aging process , sweetness , honey , and fruity off-flavors were detected and transformation products of iso-α-acids were found.
Because juvenile and senescent donor hepatocytes were likewise functional , host-derived factor ( s ) impaired senescent host liver repopulation.
Because lower vasoreactivity is associated with poor outcomes , studies of the impact of antihypertensive on vasoreactivity are important.
Because LTL varies widely between individuals in a given age group , it has been hypothesized to be a marker of biological aging.
Because many cardiovascular risks are modifiable , it may be possible to maintain brain health and to prevent dementia in later life.
Because many of these findings represent modifiable risk factors , they can translate into public health initiatives to lower BC risk.
Because mitochondrial damage can accelerate aging , we tested the hypothesis that mitochondrial dysfunction impairs stem cell renewal or function.
Because most patients may present immune reconstitution inflammatory syndrome ( IRIS ) , steroid therapy must be considered immediately.
Because NHL is a heterogeneous condition , we also examined survival in diffuse large B-cell lymphoma ( DLBCL ) .
Because NKX3.1 is haploinsufficient , strategies to increase its protein stability could lead to new therapies.
Because no pharmacological treatments are currently available for late stage of atrophic AMD , any new therapy would have extensive market potential.
Because normal body temperatures show large variations , the same may be expected for increased temperatures in fever.
Because of age-related improvements in emotion-regulation abilities , stereotype threat does not seem to reduce older adults ' executive-control resources.
Because of a lack of data , the working decision algorithm remains to be fully developed and evaluated.
Because of diverse pharmaceutical interactions , combinations of different drugs do not work well in concert and result in adverse physiological conditions.
Because of high-aging Japanese society , high-risk patients with multiple co-morbidities have been increasing in regular open-heart surgery.
Because of increased use of healthcare resources , resistant hypertensive patients should be identified early , and greater efforts made to control their blood pressures.
Because of insufficiencies in tumor vasculature , cells often are exposed to a hostile microenvironment that is low in oxygen ( hypoxic ) and nutrients.
Because of its complexity , the knee is prone to trauma , arthritis and the impact of aging.
Because of its effect on ambulation and mobility , it has significant functional impact and is associated with considerable medical costs.
Because of its high prevalence and possible association with medical and psychiatric co-morbidities , TTH has a major socioeconomic impact.
Because of its high prevalence and social impact , hearing impairment is a major public health problem.
Because of its importance , it is of extreme significance to understand the transcriptional mechanisms governing its expression.
Because of its limited linguistic demands , the test is appropriate for persons with limited language use or from different linguistic backgrounds.
Because of its long latency , BPH is a good target for prevention.
Because of its role in cell growth and invasion , aberrant Phospholipase C γ signalling can contribute to carcinogenesis.
Because of its specific geriatric focus , the MNA should be recommended as the basis for nutritional evaluation in older people.
Because of limited opportunities to learn about rural practice settings , nursing students may be reluctant to select rural practice locations.
Because of limited statistical power , it was not possible to draw conclusions about the effects of the co-occurrence of some syndromes on poorer outcomes.
Because of possible ethnic and geographic differences in third molar development , population specific researches were recommended.
Because of the above reasons , this research implementation forms a wireless platform of information connection system and medical data analysis.
Because of the change in sex composition of the workforce , some researchers conclude that pharmacist shortages will be even more critical in the future.
Because of the characteristics of the DNA replication process , only telomerase is able to elongate the telomeric sequence.
Because of the complexity of skin aging , the exact definition of biomarkers is a major research challenge.
Because of the dearth of biomarkers of aging , it has been difficult to test the hypothesis that obesity increases tissue age.
Because of the effects of age and gender on most of the scales , age and gender specific values are presented.
Because of the extremely high malignance , this disease is usually diagnosed at its advanced stage and recurs even after surgical excision.
Because of the global aging society , outpatients need to improve medication safety more than inpatients.
Because of the heterogeneity of the disease and substantial individual differences in progression , classification and grading of cartilage degeneration represents a complex task.
Because of the high prevalence of asymptomatic Toxoplasmosis and an increasing population of older adults this finding is of high relevance for public health.
Because of the high rate of mortality and morbidity , assessing the impact and progression of this disease is essential.
Because of the increased life constraints and physical problems , however , maintenance of positive affect might be challenging for elderly people.
Because of their ability to modulate cell death , polyphenols have been proposed as chemopreventive and therapeutic agents.
Because of their characteristic thick skin and flat , wide facial geometry , satisfactory facelift results can be difficult to achieve in these patients.
Because of their high energy requirements , neurons are especially vulnerable to injury and death from dysfunctional mitochondria.
Because of their intrinsic strengths and weaknesses , no single approach can fully unravel the complexities of fundamental biological events.
Because of their osteolytic aspect and biologic behaviour , these SREs are more common in patients with bone metastases from RCC than from other malignancies.
Because of their particularity and complexity , both problems are attractive yet challenging to computer-based application system designers.
Because of their reach across the genome , epigenetic mechanisms may provide a unique integrative framework for the pathologic diversity and complexity of AD.
Because of their small size and functional diversity , it is difficult to study them using magnetic resonance imaging ( MRI ) .
Because of the lack of literature on older patients with VWD , we discuss different aspects related to ageing in those patients.
Because of the link between sleep and circadian rhythms , changes in bedtime lead to changes in the amount of sleep obtained.
Because of the many extant and highly discrepant segmentation protocols , comparing results across studies is difficult.
Because of the modulation of the mechanisms involved in the inflammatory-oxidative stress cycle , resveratrol could play an important role in controlling CKD-related metabolic derangements.
Because of the multimodal nature of the activity , exergames provide an effective tool for remediation of age-related problems.
Because of the multiple areas treated , some patients experienced multiple AEs.
Because of the nearly universal association with other degenerative changes , we urge caution before diagnosing Baastrup disease as the cause of back pain.
Because of the pivotal role of APP and Aβ in AD pathogenesis , it is essential to understand how APP and Aβ modulate synaptic function.
Because of the potential for multiple ( perhaps visceral ) lesions and the possibility of overtreatment , accurate diagnosis is of utmost importance.
Because of the potential morbidity associated with surgery , the use of mini-invasive techniques have expanded considerably.
Because of the presence of the UPS in the nucleus , the UPS function may be more important for clearing misfolded proteins in the nucleus.
Because of the quinone moiety within the structure of Dox , this agent undergoes redox cycling to produce superoxide free radical peripherally.
Because of the relatively low incidence of drowning victims at emergency departments , most emergency physicians do not routinely handle drowning victims.
Because of these articles many physicians found to have a non-therapeutic behavior in case of PD.
Because of the significant therapeutic options , differential diagnostic work-up is mandatory also in elderly patients.
Because of the similarities between osteoporosis and sarcopenia , alfacalcidol used for osteoporosis might be beneficial for low muscle mass.
Because of the similarity in the amino acid sequences between VASH1 and VASH2 , we hypothesized that they shared the bioactive center.
Because of the small number of studies , meta-analysis was only conducted for studies that used behavioral PM measures in adults to integrate findings.
Because of the small sample size in the category of @number@ to @number@ the two highest categories were combined into a single group.
Because of the strong conservation of TGF-β family ligand functions and signaling mechanisms , studies from multiple animal systems have yielded complementary and synergistic insights.
Because of the unique characteristics of elderly people with T2DM , therapeutic strategy and focus should be tailored to suit this population.
Because of this , many clinicians question whether BMI is an accurate predictor of obesity in aging women.
Because of this , new lipid-modulating drugs are urgently required.
Because of this , we predicted that stereotype threat might reduce older adults ' memory errors.
Because of variability among populations , validation in independent samples is required.
Because of variability in assessment methodologies , mixed responses were found for education interventions aimed at improving inappropriate prescribing.
Because older adults often use muscle coactivation , we expected older adults to use greater muscle coactivation during motor adaptation than young adults.
Because older employees are a vulnerable work group , understanding the perceived health effects of work may guide future workplace program development and policy.
Because only 40-50% of the result of microfattransfer is permanent touching up is often necessary.
Because Osbpl2 has been proposed as a target of miR-96 , we investigated homozygous Mir96 mutant mice for its upregulation.
Because outcome in HFASD is more related to adaptive behavior skills than cognitive level it is important to identify predictors of adaptive behavior.
Because patient age was highly correlated with several other variables , the analysis was stratified by age ( < 45 vs. ≥45 years ) .
Because people age differently , age is not a sufficient marker of susceptibility to disabilities , morbidities , and mortality.
Because performing regional anesthesia is time-consuming and requires expertise , many surgeons prefer local or general anesthesia for vascular access surgery.
Because physical health problems , emotion work , and marital dynamics are gendered , we consider how these processes differ for women and men.
Because physical inactivity has many adverse consequences , work is needed to develop safe and enjoyable exercise programs for patients with PD.
Because physiological decline varies among older adults , cancer treatment requires an individualized approach.
Because phytoestrogens have been associated with an improvement in metabolic parameters , we evaluated their role in men undergoing ADT.
Because PSP is associated with tau protein abnormalities , there is growing interest in clinical trials of new tau-directed therapies.
Because quality of care turned out to be similar , we focus here on the costs.
Because residency programs vary in curricula and length , effectively comparing outcomes is difficult.
Because rs3865444 is in the CD33 promoter region , we sought the functional polymorphism by sequencing CD33 from the promoter through exon @number@
Because samples in case-control studies are collected after disease development , whether DNA hypomethylation is causal or just associated with cancer development is still unclear.
Because Sir2 has been identified as a NAD⁺-dependent histone deacetylase , researchers have attributed its lifespan-extending utilities to gene silencing.
Because sleep differs across phylogeny and ontogeny it is important to validate the use of zebrafish in elucidating the neural substrates of sleep.
Because smooth face-to-face communication is the key to maintaining these networks , measuring the smoothness of such communication is an important issue.
Because some diabetes-related comorbidities are potential modifiable risk factors , preventing and reducing the excess risk of disability associated with diabetes needs further study.
Because some premenopausal women develop hypertension , estrogen may play a different role in these women.
Because some vowels and consonants have predominantly low-frequency acoustic energy , poor low-frequency hearing may impair communication in HIV + individuals.
Because South Korea is rapidly becoming an aging population , this high elderly suicidal rate will only get worse.
Because split-belt walking is a novel task for adults and children alike , we used it to investigate how motor adaptation matures during human development.
Because subanalyses revealed that SC may reduce HbA1c and albuminuria in some patients with T2DM with DKD , further studies may be warranted.
Because subtypes likely reflect distinct underlying etiologies , their identification may facilitate future genetic and pharmacotherapeutic studies.
Because TDP-43 aggregation is a component of nearly all cases of ALS , targeting ataxin-2 could represent a broadly effective therapeutic strategy.
Because the 3-Tier Assessment System was designed to identify limitations normally associated with aging , the present analyses focus on drivers age @number@ and older.
Because the associations reported are observational , no conclusions can be made regarding causality.
Because the CNS is isolated from the peripheral milieu by the blood-brain barrier , remyelination is thought to be controlled by the CNS microenvironment.
Because the connotation of neuroinflammation is inherently negative and maladaptive , the majority of research focus is on the pathological aspects of neuroinflammation.
Because the difference in response rate between the groups was @percent@ , propranolol was considered noninferior.
Because the elderly are the fastest growing segment of the population , the number of older adults with bipolar disorder is increasing.
Because the intertwining relationships of these factors are complex , effective treatment options are still under investigation.
Because the IVD is avascular , these cells rely on passive diffusion of nutrients to survive.
Because the kidney plays a role in reducing glycative stress , renal dysfunction results in increased glycative stress.
Because the LGN morphology is affected by different diseases , it is of interest to analyze its morphology by segmentation.
Because the microneedle therapy system is accessible for home use , health care providers need to be aware of its potential consequences.
Because the model is intended for policy exploration , stylized numbers were used as model inputs.
Because the molecule was negative in genotoxicity assays it was classified as a non-genotoxic carcinogen.
Because the number of patients with lifestyle-related disease is getting larger , it is necessary to prevent fracture in those.
Because the number of persons aged @number@ and older is expected to rise in the next decades , disease prevention will become an important issue.
Because the prevalence of chronic kidney disease increases with age , telomere length and telomerase activity may play a role in its progression.
Because there are few effective treatments for the disease , more research on its etiology and mechanisms is warranted and needed.
Because there are several common sources of sleep problems in midlife women , the cause of an individual woman's sleep disturbance may be multifactorial.
Because the retina provides a noninvasive window to assess the microcirculation , we determined whether quantitatively measured retinal microvascular parameters are associated with AD.
Because these cells derive from subjects ranging in age into their sixties , this system permits human aging studies previously possible only in rodent systems.
Because these conditions are highly prevalent in OSA , we hypothesized that telomere length ( TL ) would be reduced in OSA patients.
Because these values are misbalanced now , equal accessibility of care and conditions for social participation are disappearing.
Because the undermining is limited , minor swelling occurs , and the postoperative recovery is shorter and faster.
Because the value of PSAV is PSA-dependent , the PSA level should be taken into account when interpreting PSAV.
Because this age group is particularly challenging to recruit , careful planning and ongoing evaluation is important for successful participant recruitment and retention.
Because this link was observed during follow-up , it is possible that increased arterial stiffness favors the increase in the PR interval with age.
Because this SNP is an insertion / deletion of @number@ bp , it might cause an alteration in SHIP2 expression.
Because threshold testing is based on passive motion , it most closely reflects afferent sensory feedback processing ( ie , proprioception ) .
Because TPA is readily available at no additional risk or cost , it is a convenient additional tool for preoperative risk assessment and counseling.
Because TRPV5 and Klotho coexpress in the distal convoluted tubule , we investigated whether Klotho regulates TRPV5 action from inside the cell.
Because unmet needs often have negative consequences , it is increasingly important to identify factors associated with unmet needs.
Because VASH1 lacks a classical signal sequence , it is not clear how ECs secrete VASH1.
Because WMLs are linked to both dementia and stroke risks , these results could have implications for future preventive trials.
Beclin-1 , a well-known key regulator of autophagy , has been implicated in many disorders , including cancer , aging , and degenerative diseases.
Beclin-1 knockdown rendered them significantly more sensitive to chemotherapy through activating apoptosis pathway.
Beclin1 plays a key role in the initial steps of autophagosome formation.
Bed rest significantly decreased lipolysis and tended to increase glucose uptake in the SCFAT of both CON and FDR subjects.
Bedside nursing care provides protection from pulmonary complications.
Bedside sublingual video-microscopy may detect worse flow and perfusion associated with this endotheliopathy.
Before amyloid formation , peptides cleaved from the amyloid precursor protein ( APP ) exist as soluble oligomers.
Before and after 2-hour soccer games , HRV and blood pressure were recorded.
Before and after an incremental exercise test , oxidative stress markers were assessed.
Before and after cold provocation , skin temperature and skin perfusion were measured.
Before and after each intervention , plasma ADMA concentrations and carotid arterial compliance were measured in all participants.
Before and after intervention , salivary cortisol was collected at four different times of the day.
Before and after photographs along with adverse effects were recorded.
Before and after the intervention , anthropometric and metabolic parameters , along with abdominal fat distribution and PPAR-γ2 polymorphisms , were measured.
Before and after the intervention or no-intervention periods , subjects underwent scanning sessions in diffusion-weighted imaging to measure MD.
Before and after the intervention , students completed a questionnaire measuring their perceived distribution of ten tasks between dentists and dental hygienists.
Before and after the program , data was collected on vital signs , physical function and self reported quality of life.
Before and after the workout , plasma lactate was measured while a beat-to-beat heart rate recording was executed during each workout.
Before and immediately after the protocol , their responses to lateral waist-pull perturbations were recorded.
Before and @number@ weeks after treatment the patients responded to IIEF-5 questionnaire.
Before anti-HCV therapy , G1 patients had a higher HCV RNA level than G2 patients.
Before any clinical implications can be outlined , health outcomes ( validity ) , causes , and prevention of frailty should be investigated.
Before applying them in clinical practice , these tools should be examined in ongoing large clinical trials.
Before a preventive strategy is favoured , however , authorities should carefully analyse the cost to benefit ratio of each strategy.
Before ASD repair , early diastolic mitral annular velocity ( e' ) on lateral , an index of ventricular relaxation , showed an age-related decrease.
Before attempting to create new criteria , a multidisciplinary group-task is urged to identify and minimize the uncontrolled proliferation of definitions.
Before awakening , most power was within frequencies ≤4 Hz , but trends over time were variable.
Before CGA , @number@ of these patients were under-treated ( @percent@ ) ; after CGA , @number@ patients ( @percent@ ) were under-treated.
Before cochlear implantation , all patients scored @percent@ on the monosyllabic word recognition test in free field at @number@ dB SPL intensity level.
Before commencing T treatment , side effects and consequent higher mortality in older frail men have to be avoided.
Before completion of pubertal development it results in eunuchoid traits that can be easily detected.
Before death , individuals with this disorder have usually become dependent on caregivers.
Before diagnosis , cases posed € @number@ more health costs per year than controls.
Before each record , he performed an incremental test on a cycling ergometer.
Before its use in real life contexts , this paper presents results from a validation process of the framework.
Before leaving the house , it is a good idea to check for road closures that may affect the morning commute.
Before @number@ the UK saw a decline in the number of nurses coming forward to undertake a postgraduate programme in specialist community practice.
Before @number@ which is the year the World Anti-Doping Agency banned its use , glycerol was commonly used by athletes for hyperhydration purposes.
Before retirement , a dominant 7-day rhythm of sleep duration as well as an annual periodicity was revealed by spectral analysis.
Before retirement @percent@ to @percent@ of participants reported having disturbed sleep.
Before seeking medical attention , family carers modified physical or social environments because of symptoms.
Before that , information of patient and its relatives and a particular attention for elderly during anaesthesia and perioperative period should be considered.
Before the COPM ( or SIGA ) can be recommended as goal-setting instrument , its psychometric properties require further research.
Before the KOP-Q can be used in other countries , cross-cultural tests should again be performed.
Before the use of DSWL , women usually practice diets and men practice fluid consumption.
Before this age , children exhibited restricted perceptual-motor coordination with a high frequency of racket oscillation and a poor level of performance.
Before transfusion , and at selected time points after the start of transfusion , endothelial function was assessed using noninvasive flow-mediated dilation assays.
Beginning at puberty , women develop mood disorders twice as often as men.
Beginning in @date@ , we prospectively collected data from all patients with the same diagnosis and procedure.
Beginning in the late 1970s , the paper stimulated an explosion of epidemiologic research on social support and human health.
Beginning with the sixth decade of life , the human immune system undergoes dramatic aging-related changes , which continuously progress to a state of immunosenescence.
Behavioral analysis revealed that working memory performance was more impaired by interruptions in older compared with younger adults.
Behavioral and conventional fMRI results replicated age group by WM load interactions.
Behavioral and EEG data were collected during a lexical decision task , in which words and symbol strings were presented.
Behavioral and electrophysiological data related to performance in an auditory Go / NoGo task were analyzed in young and older adults in the present study.
Behavioral changes , such as depression , anxiety , apathy , and irritability , were reported.
Behavioral change theories were adopted to guide the design of the health messages.
Behavioral data indicated that a higher stress score among elderly participants related to impaired performance on both tasks.
Behavioral data revealed significant relationships between measurements of depression and tinnitus-related distress.
Behavioral data showed similar age-related deficits in source memory accuracy for both words and objects.
Behavioral data were collected using standardized cognitive assessments , self-report measures of mood and social functioning.
Behavioral deficits are more frequent in subjects with dementia.
Behavioral development in children involves a complex and dynamic set of genetically guided processes by which neural structures interact constantly with the environment.
Behavioral disinhibition was measured using the Neuropsychiatric Inventory ( Cummings , @number@ Cummings et al. , @number@ ) Disinhibition Scale.
Behavioral dysexecutive disorders are highly prevalent in patients with neurological diseases but cannot be explained by cognitive dysexecutive impairments.
Behavioral evidence suggests that memory for context ( i.e. , source memory ) is more vulnerable to age-related decline than item memory.
Behavioral evidence suggests that young and older adults show a benefit in source memory accuracy when processing materials in reference to the self.
Behavioral features are also shown - retiring behavior more than agitation - and various emotions , but physical symptoms are rarely depicted.
Behavioral finance , in contrast , suggests that some workers may operate with nonlinear time discounting.
Behavioral findings suggest an inverted U-shaped pattern of prospective memory development across the lifespan.
Behavioral interleaved gradient ( BIG ) methodology was used to address movement related artifacts.
Behavioral interventions ( e.g. , rehabilitative training ) can drive functionally beneficial neural reorganization in the injured hemisphere.
Behaviorally , all participants performed better identifying targets than rejecting distractors.
Behaviorally , all participants responded faster and more accurately during the rhyme task compared to the semantic task.
Behaviorally , both time-periods were comparable in terms of visual search strategy , emotion , frequency of rehearsal and recency of the last evocation.
Behaviorally , H1 homozygosity was associated with impaired picture recognition memory in PD patients and control subjects.
Behaviorally , participants of all ages acted prosocially towards victims , fairly towards positive individuals and punishingly towards offenders.
Behaviorally , the aged rats have the capacity to recover after cortical infarcts albeit to a lower extent than the younger counterparts.
Behaviorally , the altered DMN FC positively correlated with information processing speed in both ϵ2 and ϵ4 carriers.
Behaviorally , there was impairment in the hippocampal-based discriminative fear-conditioning to context task indicating learning and memory deficit.
Behaviorally , verbal episodic memory scores of APOE ε4 carriers were slightly lower than those of noncarriers , though still within normal range.
Behaviorally , we observed the expected life-span peak in younger adults and better performance with longer presentation times.
Behavioral modifications are considered first line therapy.
Behavioral performance was paired with electroencephalographic recordings to enable insight into the underlying neural processes impacted on by cumulative stress.
Behavioral plans were recommended in @percent@ of patients.
Behavioral problems were observed in the older age group.
Behavioral results demonstrated that elderly participants performed slower but committed a similar number of errors compared to younger adults.
Behavioral results replicated earlier findings with older adults tested in the morning better able to ignore distraction than those tested in the afternoon.
Behavioral results revealed performance degradation for elderly participants only when categorizing HSF scenes.
Behavioral results showed that age differences were smaller for recognition of compounds than for unrelated word pairs.
Behavioral results showed that both young and older adults demonstrated better source memory accuracy for objects encoded self-referentially.
Behavioral results supported the pattern of an inverted U-shape with a pronounced prospective memory decrease in old adults.
Behavior and self-rated health were the strongest predictors for quality of life in this study.
Behavior Change Process Measures average Likert scores increased from @number@ ( @number@ ) to @number@ ( @number@ ) , P < @number@
Behavior often does not reveal the inner ear deficit.
Behavior of transplanted animals was assessed by rotarod test , paw grip endurance ( PaGE ) , and reflex index.
Behaviors that rely on hippocampal integrity have been the focus of extensive research using animal models and represent useful functional endpoints in pre-clinical AD research.
Behaviors were studied using the Developmental Behavior Checklist for Adults ( DBC-A ) .
Behavior trends in PAL were also measured after two years.
Behavioural and cognitive impairments have been observed in animals with lower brain DHA levels , with emphasis on loss of spatial memory and increased anxiety.
Behavioural and electrophysiological indicators of response monitoring in amateur musicians with various skill levels were collected using simple conflict tasks.
Behavioural and neurological changes in elderly subjects suggest that the spatial representations of the environment might decline compared to young participants.
Behavioural disengagement at T2 was found to mediate between familism at T1 and caregiver depression at T3.
Behavioural expressions of these alterations were dependent upon the considered condition of speed.
Behavioural symptoms and the presence of depression strongly predicted anxiety , as did staff's reaction to behavioural symptoms and their sense of competence to care.
Behavioural variability of malaria vectors poses a great challenge to existing vector control programmes with insecticide resistance already acquired to nearly all available chemical compounds.
Behaviour , lifestyle and employment choice are influenced by educational level , which may affect cognitive ability to process health information.
Behaviour-related risk factors are hurrying , risk taking , physical inactivity and fear of falling.
Behaviour was coded from tape and was analysed for temporal ( t ) -patterns using Theme ( Noldus ; Magnusson , @number@ ) .
Behind such contradictory results may be the role of depression itself as a cardiovascular risk factor and , therefore , a major confounding factor.
Being able to define self and social identity in ways that preserve a sense of social status is important to find meaning in everyday life.
Being aged in the context of everyday living was the phenomenon of interest.
Being aware of these differences in background and health characteristics may help providers to better serve older Asian clients.
Being a woman , illiterate or single were all risk factors for depressive symptoms and suicidal thoughts.
Being conserved across different phyla , TOR regulates longevity of various organisms in response to dietary conditions.
Being downhearted was predictive of confused and helpless beliefs.
Being evangelical and having more schooling constituted protective factors against smoking.
Being HIV-positive , having comorbidities and being of higher age may adversely impact health-related quality of life ( HRQL ) .
Being in an older age group appears to be associated with worsening sleep , though not always.
Being independent of age and cognitive status , neurovascular stress tests seem adequate for studying several cerebrovascular conditions affecting the aging brain.
Being isolated can cause depression , fear and insecurity.
Being listed on a transplant wait-list register was positively associated with HRQoL.
Being married and having a confidante were significantly associated with lower loneliness.
Being married and higher Fagerström test scores were also predictors of cessation tendencies.
Being notified prior to returning to work was associated with a more positive experience.
Being obese as a child also increases the likelihood of being obese as an adult , and obesity in adulthood also leads to obesity-related complications.
Being older and female were protective factors for over-consumption of sugar.
Being older and having more than one medical condition was found to increase the likelihood of self-regulation of driving.
Being old or having alcohol use disorders are two unfavorable conditions for receiving help or optimal care.
Being perceived as homey , the facility's architectural design matches caregivers ' care vision and , thus , helped them realizing this vision.
Being with other family members and friends was associated with more positive affective experiences.
Belief ratings of deep encoding strategies increased with age and , critically , accounted for better associative recognition.
Beliefs about memory , health , and lifestyle were interrelated.
Beliefs about support and feelings of personal reward from providing support explained this difference but resources and demands did not.
Beliefs based on doctrine engaged a pathway from Broca's to Wernicke's language areas.
Beliefs implying less involved SAs and evoking imagery activated a pathway from right lateral temporal to occipital regions.
Beliefs related to everyday life experiences engaged pathways involved in imagery.
Bell's palsy was found to occur with an annual incidence close to previous reports.
Belly dance , as a form of recreative leisure , provides a unique and somewhat unexpected space for women to subvert such perceptions.
Belmont Report principles focus on the well-being of the research subject , yet community-engaged investigators often eschew the role of subject for that of participant.
Belotero Balance shows consistency throughout the syringe and across manufactured lots.
Below a critical concentration , free radicals are important for signaling processes in the human body.
Below-average performance in the attention domain was more frequent for low-education patients ( χ2 ( @number@ ) = 9.8 ; p < .05 ) .
Below @number@ years , the mean CAC scores did not differ between the GFR tertiles.
Below the resting potential , stimulus-evoked activity was predominantly depressed , caused by excessive GABA-release.
Benchmarks of nursing , gerontology and the complexity of Morin as theoretical were used.
Benchmarks on values , ethics and law for the hospitals , healthcare professionals and users are questioned.
Bendamustine is also an option , especially for patients with cardiac comorbidities.
Bending strength and stability of the bone can be determined by their obtained parameters such as section modulus , cross sectional area and buckling ratio.
Benedictine Monastery of St. Andrew is probably the oldest existing Benedictine monastery in this area.
Beneficial effects of adaptive responses to low doses of insults that in higher concentrations show adverse effects are generally referred to as hormesis.
Beneficial effects on lipids and other metabolic factors and on psychological and sexual functioning progressed over the first @number@ to @number@ months and were sustained.
Beneficial effect was independent of the type of disease , type of exercise , frequency , and the intensity of the exercise intervention.
Beneficiaries residing in a facility were more likely to undergo multiple transitions to hospitals and SNFs compared with community-dwelling beneficiaries.
Benefit-cost ratio was @number@ and the net benefit was Yen @number@
Benefit from treatment and the tolerability of tumor-specific therapy , particularly whole-brain radiotherapy , are significantly lower in the elderly patients.
Benefits and limitations of this approach are discussed.
Benefits in this population included reductions in behavioural and psychological symptoms and carer burden and increased independence , task engagement and safety.
Benefits may also extend to other special populations who experience PM impairments ( e.g. , traumatic brain injury [ TBI ] , Parkinson's ) .
Benefits of current antidementia drugs are modest , both in cognitive and functional domains.
Benefits of the intervention on infant health and neurodevelopment are under study.
Benefits of treatment only emerged in these later ages , suggesting that the supplement acted on mechanisms common to aging and cancer.
Benefits were measured as a composite variable of five NA benefits weighted by cost.
Benefits were slightly attenuated but remained significant at 4-month follow-up ( all p's < @number@ ) .
Benefit with ticagrelor was seen both in invasively and noninvasively managed patients.
Benign adult familial myoclonus epilepsy ( BAFME ) is an adult onset , autosomal dominant disease characterized by cortical tremor and infrequent generalized seizures.
Benign and malignant tumors are common.
Benign Prostate hyperplasia ( BPH ) and prostate cancer ( PCa ) are the most common prostatic disorders affecting elderly men.
Benign prostatic hyperplasia ( BPH ) is a common condition in adult men and its incidence increases progressively with aging.
Benign prostatic hyperplasia ( BPH ) is a major health concern for aging men.
Benign prostatic hyperplasia ( BPH ) is one of the most common conditions associated with the aging male.
Benign prostatic hyperplasia ( BPH ) is one of the most common urological diseases in aging men.
Benign prostatic hyperplasia can be clinically significant due to lower urinary tract symptoms that take place because the gland is enlarged and obstructs urine flow.
Benign prostatic hyperplasia is considered a progressive disease intimately linked with aging.
Benzodiazepine ( BZP ) hypnotics have been the primary treatments for sleep disturbances , and are effective and safe when prescribed within the recommended guidelines.
Benzodiazepines are potentially addictive drugs : psychological and physical dependence can develop within a few weeks or years of regular or repeated use.
Benzodiazepines are widely prescribed for anxiety , although use of this class of medications has been associated with dependency and cognitive changes.
Benzodiazepines were classified as short- , intermediate- , and long-acting.
Benzodiazepines were the most commonly prescribed PIMs according to all criteria.
Benzoic acid ( BA ) , a component of various plants , has been shown to have antifungal and antioxidant effects.
Berberine also increases glucose transporter-4 ( GLUT-4 ) and glucagon-like peptide-1 ( GLP-1 ) levels.
Berberine ( BRB ) , a natural alkaloid , has a long history of medicinal use in both Ayurvedic and old Chinese medicine.
Berberine is an alkaloid that is highly concentrated in the roots , rhizomes , and stem bark of various plants.
Bereaved women had higher cortisol levels than bereaved men at W1.
Berry fruit , including cranberries , represent a rich source of phenolic bioactives that may contribute to human health.
Beside age and sex , @number@ studies used at least @number@ further PROGRESS-Plus factor for the description of participants ' baseline characteristics.
Beside amyloid-β plaques and neurofibrillary tangles , brain oxidative damage has been constantly implicated in Alzheimer's disease ( AD ) pathogenesis.
Beside behavioral data , the spectral properties of the ongoing EEG with respect to time on task and breaks were analyzed.
Beside bond strength , the performance of adhesive zirconia restorations could be affected by other variables.
Beside evolution of disease , age is a major determinant of mortality.
Beside general medical disorders , these patients have several specific features related to the craniofacial phenotype and the oral cavity.
Beside its prominent multilobular nucleolar localization in interphase cells , coexistence of NS with chromosome arms during mitosis was also observed.
Besides age and albuminuria , different profiles of risk factors accounted for the occurrence of ACS between men and women.
Besides a genome-wide analysis , we also performed an analysis which was restricted to genes related to the serotonergic signaling pathway.
Besides age-related changes , both the immune and the endocrine system exhibit significant sex-specific differences.
Besides a hearing aid , a hearing-impaired person may need other appliances , such as a better audible doorbell or an amplified telephone.
Besides a low complication and mortality rate , functional improvement was significant post-operatively.
Besides , a majority of the pharmacological studies were carried out using crude and poorly characterized extracts.
Besides a very low complication rate , none of the typical postoperative complications of aged patients occurred.
Besides behavioral deficits , neurodegenerative diseases are characterized by histological phenotypes such as neuronal death and axonopathy.
Besides , bilateral asymmetry affects values of height parameters of foot and arch.
Besides characteristic cognitive deficits , particular emotional problems support the diagnosis.
Besides , classical linear and logistic regression models were developed for comparison with EANN prediction results.
Besides , complete inhibition of acetylcholinesterase was never achieved.
Besides controlled experimental tasks , it is equally crucial to investigate language in unconstrained conversation.
Besides , correlations between sRAGE and age or follicle-stimulating hormone ( FSH ) were examined.
Besides , costs of pharmaceutical treatment regarding osteoporosis were included.
Besides , exercise potentiates the relative risk of drug consumption.
Besides few genetic mutations , many non-genetic risk factors are known to significantly influence disease onset and progression.
Besides gender , factors associated with any oxygen use or sustained oxygen therapy were non-Hispanic white race , low socioeconomic status and ≥2 comorbidities.
Besides , histone modification could regulate P66SHC gene expression.
Besides homing and differentiation in the area of injury , MSCs there elicit strong paracrine effects stimulating the processes of repair.
Besides HSF1 , the deacetylases differentially modulate the activities of unrelated DNA binding proteins.
Besides , HTN can result in various other health complications such as stroke and chronic kidney diseases , if not treated.
Besides increased heat waves to which elderly are vulnerable , global warming is anticipated to increase ozone levels and facilitate the spread of pathogens.
Besides , it has been found that this drug has anti-addictive effects.
Besides known age-related alterations like DNA-methylation changes , metabolic adaptations have been recently linked to impaired skin function in elder humans.
Besides maintaining healthy lifestyle behaviors , positive aging outcomes may also be heritable , with estimates ranging from @percent@ to @percent@.
Besides , many viruses hijack the autophagosomal pathway to support their life cycle.
Besides medical treatment and surgical or interventional revascularization , supervised exercise programs are a primary treatment modality for PAD.
Besides memory and language , executive functions are very often affected in elderly and patients with Alzheimer's disease or Parkinson's disease.
Besides mineralization mediated by matrix vesicles , a second pattern of cartilage mineralization was observed in thyroid cartilage only.
Besides , MMPs are important in neuronal damage in acute and chronic conditions as well as repair processes.
Besides neurologists , physicians from other fields must be aware of PML associated with resulted from monoclonal antibody therapy.
Besides neurons , the brain histaminergic system comprises mast cells and microglia that can also produce histamine.
Besides , PCA discriminated the AMW on the basis of their main sensorial characteristics.
Besides pharmacotherapy , non-pharmacological interventions are becoming more and more recognised.
Besides Polymethylmethacrylate ( PMMA ) injection , several techniques have been developed to augment pedicle screws.
Besides , PS-NH2 inhibit angiogenesis and proliferation of leukemia cells xenografted onto the chick chorioallantoic membrane.
Besides , RNA interfering was applied to knockdown the expression of related protein.
Besides , sensitivity analysis indicated that short-term TRT was more likely to increase PSA levels than treatment with placebo ( P < 0.00001 ) .
Besides , several angiogenic genes were upregulated in BMSCs and PMSCs in comparison with AMSCs and UMSCs.
Besides specific triggering causes , Alzheimer's disease ( AD ) involves pathophysiological pathways that are common to acute and chronic neurodegenerative disorders.
Besides , subjects with lymphopenia and long-term use of feeding tube and / or urinary catheters were significant risk factors for LTCF-acquired infections.
Besides TE , exercise with a horse may be an alternative option to older adults , provided that they want to interact with the animal.
Besides telomerase , telomere length is also regulated by several telomere-specific binding proteins.
Besides that , T2 values reflected tissue water content.
Besides that , there is ongoing debate regarding the appropriate anaesthesia technique for surgical repair of the fractured hip.
Besides , the activation of hTERT is also being documented several cancer types including carcinoma.
Besides , the association between the frailty categories and all three outcomes was slightly stronger among women.
Besides , the binding modes of representative inhibitors with gelatinase are also briefly described.
Besides , the brain pathological age is most helpful for feature reduction , thereby simplifying the relevant classification algorithm.
Besides , the C4B Q0 carrier state did not decrease with age , irrespective of smoking as an interacting variable.
Besides the capability of α-motoneurons , signaling originating from the TSCs and muscle may be impaired during aging.
Besides the chaperone functions , heat stress cognate @number@ is involved in the inflammatory signal pathways via extracellular interaction with TLR2 / TLR4.
Besides the classic SCA2 neuropathologic alterations , Lewy bodies and Lewy neurites were present in the brainstem nuclei.
Besides the complexity of organs or tissues that need to be regenerated , regenerative medicine brings additional challenges of complex regeneration processes and strategies.
Besides the human rights , the dignity , and the gradual decline of the elderly's social security are reflected.
Besides , the possible tendency and perspective for future research of this plant are discussed , as well.
Besides , the prescription of BZD increases after retirement and loneliness.
Besides the presence of these ligands , the chronic stimulation of the RAGE , or its isoforms trigger different signaling pathways and reactions.
Besides , the process of activation and proliferation of satellite cells is affected and the production of anabolic hormones and local factors is decreased.
Besides the reduced levels of ATGs , mTOR can additionally reduce MA , promoting further acceleration of protein accumulation and metabolic disturbances during aging.
Besides , there were no asymmetry in the right and left side inclinations of the mandibular fossa.
Besides these , there are some bioactive food components known as \ "phytonutrients \ " that play an important role in human health.
Besides this , AGEs react with specific cell surface receptors ( RAGEs ) .
Besides this caspase-2 has emerged as a unique caspase with potential roles in maintaining genomic stability , metabolism , autophagy and aging.
Besides this , even epigenetic mechanisms can influence this process.
Besides this , increased life expectancy and improved general health status have increased the number of elderly patients eligible for major surgery.
Besides , VEGF directly and acutely regulates the functions of multiple ion channels of the neuron membrane and changes neural excitability.
Besides vertebrate models , Drosophila models have been widely used to understand the complex events leading to AD in relation to aging.
Besides , vitamin E and coenzyme Q10 levels increased.
Besides , we have tried to understand the molecular mechanism of lithium action that triggers changes in cytoskeleton and neurites outgrowth.
Besides white adipose tissue , recent studies found important brown adipose tissue activity responsible for thermogenesis and energy dissipation in adults as well.
Beside that educational policies oriented over professionals and citizens.
Beside the light-dependent degenerative and inflammatory manifestations at the lids , the conjunctiva and the cornea patients with XP also develop malignancies early in life.
Best-corrected VA change was not significantly associated with DS change ( r = @number@ p = @number@ ) .
Best-corrected visual acuity was measured at annual study visits.
Best-fit values were determined for mouse , rat , rabbit , bovine and human lens epithelia.
Best-liked features were physical activity and socialization.
Best-practice recommendations were rarely applied in prior studies , indicating greater effects may have been achieved if recommendations were incorporated.
Best results were achieved in the domain of nursing care , where all aspects were implemented in at least @number@ % of the NHs.
Best subset regression analysis was used to derive PEs.
Be sure to keep track of the amount of time ( number of minutes ) you spend reading the article and completing the quiz.
Beta2-microglobulin is recognized as a surrogate marker of middle-molecule uraemic toxins and represents a key component of dialysis-associated amyloidosis.
Beta activity varied depending on the tapping condition in the elderly but not in the young group.
Beta-amyloid ( Aβ ) deposition is one of the hallmarks of Alzheimer's disease ( AD ) .
Beta-amyloid @number@ ( Aβ42 ) concentrations in cerebrospinal fluid ( CSF ) are significantly decreased in Alzheimer's disease ( AD ) .
Beta-catenin-activating phosphorylation at position Ser675 was increased in aging mammary arteries , confirming the activation of this pathway.
Beta-catenin silencing demonstrated that Wnt induction of cyclin D1 expression is β-catenin dependent.
Beta-cell replication dramatically declines with age.
Beta chorionic gonadotrophin , insulin , progesterone and estradiol were determined using chemilumiscence imunoassay technique on MAGLUMI @number@ analyzer.
Beta-galactosidase activity reflects the rate of cellular aging in vitro.
Betaine is a major water-soluble component of Lycium chinense.
Beta-myrcene is also the major constituent of hop and bay oils , which are used in the manufacture of alcoholic beverages.
Beta oscillations are involved in movement and have previously been linked to levels of the inhibitory neurotransmitter GABA.
Beta power elevation in resting-state electroencephalography has previously been linked to cortical disinhibition and hyperexcitability.
BET stimulated ERK signaling , key pathway involved in osteoblastogenesis and calcium signaling.
Better abilities appeared not associated with better judgment.
Better access to recreational facilities may benefit middle-aged and older adults by enabling them to maintain activity levels as they age.
Better adherence to circuit training improved general health , and better adherence to group meetings improved timed standing.
Better adherence to MeDi was associated with lower level of hsCRP ( p = 0.003 ) , but not fasting insulin or adiponectin.
Better and earlier treatment of ADHD may prevent the development of depression in the presence of life events associated with ADHD.
Better care requires inclusion of such differences as part of the comprehensive evaluation of the oldest old adults.
Better characterization of genetic profiles in age-related macular degeneration may be important for screening and future therapeutic strategies for this vision-threatening condition.
Better cognitive performance was observed for the breathing group as regards abstraction and mental flexibility.
Better communication and collaboration between family physicians and the oncology team are needed to facilitate shared care in cancer follow-up.
Better delayed recall was significantly associated with less underreporting on the number of physician visits.
Better diet quality was associated with improved asthma symptoms over time in never smokers , independently of BMI.
Better efficacy was obtained in the high-dose treatment group.
Better-eye VF mean deviation ( MD ) averaged @number@ decibels ( dB ) in controls and @number@ dB in glaucoma subjects.
Better financial status and being employed were both associated with more positive attitudes to aging and better self-reported physical health.
Better functional results have been achieved compared with conventional suture technique with a trend toward a lower recurrence rate.
Better information must be associated with regular clinical examination.
Better insight into the mechanisms underlying renoprotective roles of autophagy will pave the way toward novel therapies for kidney diseases.
Better Living Health and Community Services developed a 12-week community-based nutrition information series ( NIS ) for people aged @number@ or older.
Better measurement tools specifically for assessing cosmesis after AK treatment are needed.
Better measures , including simulation tests , are needed to assess resilience and its determinants.
Better mental status and delayed word recall were associated with more concordant reporting and less underreporting on health services use.
Better performance in all UFOV subtests was associated with faster speed of processing , as reflected by decreases in P3b latency.
Better performance on the youngest children's right part and on the oldest children's left part was observed.
Better performance was found ( p = @number@ ) , explaining @percent@ of the mean variation in cognitive composite score in men.
Better planned suicide attempts were also associated with willingness to wait for larger rewards.
Better-powered human neuroimaging studies suggest that the brain characteristics of autism are qualitatively , rather than simply quantitatively , different between males and females.
Better results for Walkers were observed in most subjective and objective outcome measures.
Better results have been reported when pharmacists are skilled and work in the context of a multidisciplinary team.
Better standing balance performance was associated with better chair rise performance in men , but not women.
Better tools to identify indolent tumors are needed to avoid overtreatment.
Better TRTs and larger word vocabulary were related to higher mental processing load across speech intelligibility levels.
Better understanding of each age specific approach and how it differs may improve our ability to study late effects of radiation across the ages.
Better understanding of oncogenes as well as synthetic lethal interactions with oncogenes will lead to new strategies for tumor-specific treatment.
Better understanding of the causes of optical alterations with aging will improve the maintenance of vision quality.
Better understanding of the long-term consequences of injury-related outcomes is needed to achieve public health goals of reducing injury and improving injury-related medical care.
Better understanding of the mechanisms that regulate growth and differentiation of glomerular epithelial stem cells may provide new clues for prevention and treatment of glomerulosclerosis.
Better understanding of the molecular mechanisms underlying the immune attack in AA will yield new drugs.
Better understanding of the most relevant pathophysiologic pathways for FGF23 may lead to therapeutic interventions against cardiovascular disease in patients with CKD.
Better understanding of these relationships should be helpful for planning effective health promotion strategies for reducing the risk of new-onset diabetes in older adults.
Better understanding of the underlying mechanisms of aging and determinants of life span will help to reduce age-related morbidity and facilitate healthy aging.
Better verbal development also was associated with the likelihood of having friends who drink in adolescence.
Between ages @number@ and @number@ years , testicular volume and metabolism remain relatively constant with only a minimal decline.
Between baseline and 1-year follow-up , @number@ of the participants without sarcopenia at baseline had developed sarcopenia.
Between baseline and discharge , @percent@ of geriatric and @percent@ of medical patients declined in physical function.
Between baseline and follow-up most people remained ' stable ' in their dietary class.
Between-country disparities were examined using between-country variance and Gini coefficient.
Between-country disparities were examined using between-country variance and the Gini coefficient.
Between @date@ and @date@ GPs referred @number@ people with a new PMR diagnosis in the past @number@ years into the study.
Between @date@ and @date@ , @number@ of @number@ persons ( @percent@ ) seeking VCT services were seropositive for E. histolytica infection.
Between @date@ and @date@ , @number@ patients were identified.
Between-group analyses showed larger frontal and central SMEs in the younger sample in the LPC latency regardless of encoding type.
Between-group comparisons revealed statistically stronger activations in the primary somatosensory cortex of young adults during the motor tasks examined.
Between-group comparisons were performed utilizing a hierarchical linear mixed model that adjusted for the nonindependence of twin data.
Between-group difference in the change of NTB total score per year was 0·022 ( @percent@ CI 0·002-0·042 , p = 0·030 ) .
Between-group differences in gray matter volume and fractional anisotropy were regionally localized across the lifespan using permutation testing and cluster-based inference.
Between-group differences of CDRs and cortico-thalamic tracts DT MRI indices were assessed.
Between-group differences were also observed for some indicators of cardiovascular health and flexibility.
Between-group differences were observed for the Geriatric Depression Scale and Hamilton Depression Rating Scale , with higher scores for patients with LLD.
Between-group interactions ( p = 0.006 ) were noted for both of these associations.
Between-group's differences were evaluated using the Quade's rank analysis of covariance.
Between-group sex differences were controlled by single-sex analysis.
Between July and @date@ , @number@ surveys were completed.
Between @number@ and @number@ age-standardized incidence rates for all cancers combined increased in @number@ of @number@ countries or territories.
Between @number@ and @number@ data were collected using questionnaires and examinations including morning and evening salivary samples.
Between @number@ and @number@ % do not disclose their pain or consider their pain as being a part of aging.
Between @number@ and @number@ mortality risks of foreigners rose strongly due to the census corrections of the migrant population.
Between @number@ and @number@ @number@ elderly persons were followed for incident depressions.
Between @number@ and @number@ @number@ morbidly obese patients over @number@ years underwent a laparoscopic sleeve gastrectomy ( LSG ) at our institution.
Between @number@ and @number@ @number@ patients received HSCT in Essen ( n = @number@ ) and Cologne ( n = @number@ ) .
Between @number@ and @number@ @number@ ( @percent@ ) became impaired in all @number@ domains.
Between @number@ and @number@ @number@ stones were characterized.
Between @number@ and @number@ over @number@ causative genes have been identified for syndromic and nonsyndromic forms of hereditary hearing loss.
Between @number@ and @number@ the percentage of elderly IBD patients in the Netherlands has been projected to rise from @percent@ to @percent@.
Between @number@ and @number@ there has been a shift away from warm-modern care ideals and towards cold-modern care ideals.
Between @number@ and @number@ years , the total SMI decreased by @percent@ in men and by @percent@ in women.
Between @percent@ and @percent@ of our study participants had been homeless at least once by age @number@ years.
Between the 6th and 9th year after baseline , @percent@ were diagnosed with all-cause dementia , @percent@ of whom had AD.
Between these extreme conditions , there are other common skin lesions , e.g. , photoageing.
Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects.
Bevacizumab , a neutralizing anti-VEGF monoclonal antibody , is developed as the first anti-angiogenic drug in @number@
Beyond aging , this is particularly dependent on BP control particularly at nighttime , on drug therapy , and on highly abnormal glucose control.
Beyond breast cancer , little is known regarding the prognostic significance of mammographic features.
Beyond genotype , the effect of patient characteristics on maintenance dose has not been explored in detail.
Beyond its function in hemostasis , platelets activation has an important role in cardiovascular diseases ( CVD ) development.
Beyond @number@ years of age , men experience a decline in the production of testosterone , yet only a few develop late-onset hypogonadism.
Beyond overt under- or overactivity of hormonal axes , changes in the concentrations of regulatory hormones may also impact on health and disease.
Beyond that , IGF-independent actions mediated by intracellular IGFBP-3 including nuclear-IGFBP-3 , have also been described.
Beyond the economic consequences of this projection , this changing demographic portends significant changes in the social realm.
Beyond the established effects of muscle loading on bone , a complex network of hormones and growth factors integrates these adjacent tissues.
Beyond their own family caregivers , home healthcare nurses play a pivotal role in caring for those dying at home.
Beyond the proposal of 2DG as a candidate CRM , the field has grown steadily with many investigators proposing other strategies , including novel anti-glycolytics.
Beyond these indication PDT is now widely used for the treatment of various others skin tumors and infectious or inflammatory skin disorders.
Beyond this age , subsidiary products of metabolism and cell damage accumulate , and the phenotypes of ageing appear , causing disease formation.
Beyond this important role , in recent studies FX has shown a great antioxidant activity , anti-cancer , anti-diabetic and anti-photoaging properties.
Beyond this metabolic activity , ALC provides acetyl groups for acetylcholine synthesis , exerts a cholinergic effect and optimizes the balance of energy processes.
Beyond visual analysis , several monitoring devices allow an automated treatment of the electroencephalographic ( EEG ) signal , combining time and frequency domain analysis.
BF atrophy in MCI correlated with both impaired memory function and attentional control deficits , whereas hippocampus volume was more specifically associated with memory deficits.
BF infants did not differ from those receiving the LP formula in any of these parameters.
BFV rate variability identifies groups of children with varying degrees of \ "sensitivity \ " to the influence of seasonal factors.
B. gallinarum goup was detected in only nine subjects , while B. minimum and B. mongoliense were undetected at any age.
BHB inhibited NLRP3 inflammasome in S100A9 fibril-primed and urate crystal-activated macrophages , which serve to recruit inflammatory neutrophils in joints.
BHB levels are elevated by starvation , caloric restriction , high-intensity exercise , or the low-carbohydrate ketogenic diet.
BHB reduces NLRP3 inflammasome-mediated interleukin ( IL ) -1β and IL-18 production in human monocytes.
B-Hg levels were also positively correlated with blood albumin levels ( p = 0.015 ) .
BHI values were @number@.66±0.20 in the first group , @number@.35±0.31 in the second and @number@.69±0.30 in the third group.
Biallelic damaging heterozygous variants in both MCM8 and MCM9 were identified in @number@ participant.
Bias due to complex patterns of measurement error within diet scores cannot be excluded.
Biases of > 10% were present for @percent@ of samples for LDL-C , while for HDL-C this value was @percent@.
Bias indicates capture of attention , whereas congruency and incongruency imply vigilance and disengagement difficulty , respectively.
Bibliographies and previous reviews were examined to identify additional studies.
Bibliographies of pertinent articles were also examined.
Bibliographies of publications identified were also reviewed.
Bibliographies of relevant publications were further explored for additional relevant citations.
Bibliographies of selected references were also evaluated for relevant articles.
Biceps brachii elasticity decreased and rectus femoris elasticity increased with increasing body mass index.
Bidirectional associations between anxiety and cognitive performance were found among measures of processing speed , attention , and memory but not visuospatial abilities.
Bidirectional trafficking of Bdnf , NT-3 , and other neurotrophic factors contribute to intra- and intercellular signaling , affecting the axon's cellular environment and survival.
BIDS Apps overcome this limitation by taking advantage of the Singularity container technology.
Bielschowsky silver stain revealed mostly sparse neocortical neuritic plaques , whereas diffuse plaques were frequent.
Bifidobacteria are one of the major components in human microbiota that are suggested to function in maintaining human health.
Bigenic mice exhibited an age-dependent increase in BLI signals that correlated with the deposition of Aβ in the brain.
Bigger and better has been the mantra of Western medical care for decades , leading to costlier but not necessarily better care.
Biguanide-induced inactivation of mTORC1 subsequently inhibits growth through transcriptional induction of ACAD10.
Biking and running are frequently recommended as forms of exercise.
Bikram yoga is an exotic form of physical activity combining hatha yoga and thermal therapy that could positively impact metabolic health.
Bilateral aphakia / pseudophakia was slightly higher in the south ( @percent@ ) than in the north ( @percent@ ; P < 0.03 ) .
Bilateral caudate , thalamus , hippocampi , and cerebellum were prominently atrophied.
Bilateral elongation was most commonly found than unilateral elongation , and both types of elongation were frequently seen in males compared with females.
Bilateral femoral neck BMD measurement can improve detection rates of OP.
Bilateral infiltrates with diffuse and pathy distribution were the predominant features in chest HRCT.
Bilaterally , ID was found in @date@ cases.
Bilateral maximal occlusal force in the intercuspal position was measured with pressure sensitive sheets.
Bilateral plantar pressure and temporal symmetry ratios were calculated in a subset of the cohort.
Bilateral pleural effusion is distinctly associated with high mortality.
Bilateral pseudophakia can almost imitate the physiological condition of phakia except for the need to use glasses.
Bilateral shoulder radiographs were taken , and the grade of OA was evaluated using the Samilson-Prieto method.
Bile acids are FXR physiological ligands.
Biliary AP was the most frequent primary cause.
Bilingualism as a component of cognitive reserve has been claimed to delay the onset of Alzheimer's disease ( AD ) .
Bilingualism has been associated with successful aging.
Bilingualism has been found to delay onset of dementia and this has been attributed to an advantage in executive control in bilinguals.
Bilingualism has been reported to delay the age of retrospective report of first symptom in dementia.
Bilingualism was overall associated with increased GM in the ACC.
Bilingual participants included early-exposed ( bilingual exposure from birth ) and later-exposed individuals ( bilingual exposure between ages 4-6 ) .
Bilirubin can be oxidized to biliverdin by scavenging peroxyl radicals.
Bilirubin has been demonstrated to protect neurons from oxidative stress in vivo and in vitro.
Biliverdin / bilirubin may be possible therapeutic candidates to treat nervous system disease related with oxidative damage.
Biliverdin reductase-bound 4-hydroxynonenals were not modified in hippocampi and cerebella from AD and MCI subjects.
Bimatoprost ( Lumigan ) is a synthetic prostamide that reduces intraocular pressure ( IOP ) by increasing the outflow of aqueous humour.
Bi-monthly Fiestas de Baile ( dance parties ) are also included , in which participants dance and practice what they have learned.
BIN1 is known to be abnormally expressed in another human disease , myotonic dystrophy , which also features prominent NFT pathology.
Binary logistic regression , adjusted for the variables ( sex and osteoarticular diseases ) , was used to express the magnitude of these associations.
Binary logistic regression analyses adjusting for possible explanatory covariates were conducted sequentially.
Binary logistic regression analyses ( Odds Ratio ) were used to measure strengths of relationships.
Binary logistic regression analyses were used to assess associations between experiences of violence and gender , socioeconomic conditions , and social relations.
Binary logistic regression analysis , stratified by gender was used.
Binary logistic regression analysis was performed to investigate any independent association between vitamin D status and the risks of MCI or dementia.
Binary logistic regression analysis was performed to investigate the independent association between thyroid function and cognitive impairment.
Binary logistic regression and ( ROC ) curve analyses were conducted in order to assess diagnostic accuracy parameters for MMSE and SMMSE scores.
Binary logistic regression models were used to analyze associations , controlling for potential confounders.
Binary logistic regression models were used to evaluate the association between rare variant status and ocular phenotypes.
Binary logistic regression model was used to test the effects of the independent variables on home nursing care.
Binary logistic regression was performed.
Binary logistic regression was used to control for confounding variables.
Binary logistic regression was used to obtain the factors that increased the odds of having ADL disability at follow-up.
Binary logistics regression analysis , Pearson's correlation analysis , and Duncan's ( multiple range ) test were used for statistical analysis.
Binary multivariable logistic regression was used to evaluate the potential association between MCI and these factors.
Binding by the KIR4.1-specific control IgG was quenched only by lysates containing KIR4.1.
Binding immunoglobulin protein ( BiP ) is an ER chaperone that is central to ER function.
Binding of Cu2 + and Zn2 + ions to α-crystallin leads to enhanced chaperone function.
Binding ratios of [ ( @number@ ) F ] FP-CIT were obtained in the putamen and caudate using the occipital cortex as reference.
Binding studies by ELISA and surface plasmon resonance using conformation-specific monoclonal antibodies implied a six-helix bundle conformation.
Binocular acuities were tested with the Teller acuity card procedure.
Binocular subjective amplitude of accommodation was measured before and after a prolonged reading exercise , using the RAF rule.
Binocular summation of contrast signals declined with age , independent of interocular differences.
( B ) In vivo cross-polarized image at @number@ nm.
Bioactive compounds analyses were performed using a high-performance liquid chromatography-photodiode array detector ( HPLC-PDA ) system.
Bioactive compounds are considered safe and have been shown to alter genetic and epigenetic profiles of tumor cells.
Bioactive compounds from natural sources , due to their widely-recognized benefits , have been exploited as cosmeceutical ingredients.
Bioactive food components have shown potential health benefits for more than a decade.
Bioactive IGF1 were identical in males and females ( P = 0.31 ) , decreasing with age.
Bioactive natural compounds from plant-derived sources have received substantial interest due to their potential therapeutic and preventive effects toward various human diseases.
Bioactivities of grape products are highly attributed to the presence of health promoting phytochemicals in them.
Bio-Alcamid polyacrylamide gel ( Polymekon , Milan , Italy ) is a filler that has potential to cause adverse reactions.
Bioavailability of residues in soil was compared with a spiked soil aged for 90d in laboratory.
Bioavailability of tetrahydrobiopterin ( BH4 ) , an essential cofactor for catecholamine synthesis , is reduced with aging.
Bioavailable testosterone was calculated.
Biochem.
Biochem.
Biochem.
Biochem.
Biochem.
Biochemical analyses showed that peptide-induced α5β1 integrin priming transiently increased PI3K / Akt phosphorylation and promoted Wnt / β-catenin transcriptional activity independently of RRET.
Biochemical analysis revealed that the amyloid consisted mainly of variant TTR in intraocular tissues with a percentage > @percent@.
Biochemical and histological examinations failed to identify any abnormalities caused by nanoparticle administration.
Biochemical data suggest an alteration in the balance between proteases and protease inhibitors in eyes that lie at the extremes of choroidal thickness.
Biochemically , RECQ5 alleviates the inhibitory effect of RAD51 on @number@'-flap DNA cleavage by MUS81-EME1 through its RAD51 filament disruption activity.
Biochemically these strains are characterized by reduced mitochondrial membrane potential and a lowered ATP content.
Biochemical markers for ND lack sensitivity or specificity for diagnosis or for tracking response to therapy today.
Biochemical markers of bone and calcium / phosphate metabolism were assessed.
Biochemical tests and in vivo assays in Xenopus laevis embryos suggest that these mutations may behave as gain-of-function alleles.
Biocompatibility was tested using keratinocyte and neutrophil cell lines in the XTT assay.
Biocultural knowledge provides valuable insight into ecological processes , and can guide conservation practitioners in local contexts.
Biodegradable ceramic fillers are added to adjust the paste workability.
Biodegradable thermogels are a class of such supramolecular assembled materials.
Biodemography is a promising scientific approach based on using demographic data and methods for getting insights into biological mechanisms of observed processes.
Biodistribution and optimal hUCB cell dose for transplantation have been determined in preclinical studies.
Biodynes , tocotrienol-rich fraction ( TRF ) , and tocopherol have shown antiaging properties.
Bioelectrical activity of PFM was recorded using a surface electromyographic instrument in the supine position.
Bioelectrical impedance analysis ( BIA ) derived phase angle ( PA ) reflects cell membrane integrity and function.
Bioelectrical impedance analysis ( BIA ) has been used to estimate skeletal muscle mass , but its application in the elderly is not optimal.
Bioelectrical impedance analysis ( BIA ) is easy to perform , non-invasive , relatively inexpensive , and portable.
Bioelectrical impedance analysis ( BIA ) was performed with a single-frequency tetrapolar impedance analyzer after the athletes had fasted overnight for @number@ h.
Bioelectrical impedance measurements of lean body mass were taken annually.
Bioelectrical impendence ( BIA ) method was used to estimate BF.
Bioelectromagnetics.
Bioenergetic failure is a feature of Alzheimer's disease ( AD ) .
Bioenergetics of artery smooth muscle cells is critical in cardiovascular health and disease.
Bioenergetic studies revealed that eHSP72 altered pancreatic β-cell metabolism.
Bioenergetic system-level therapeutics personalized to bioenergetic phenotype would target bioenergetic deficits across the prodromal and clinical stages to prevent and delay progression of AD.
Bioequivalence between cobicistat ( COBI ) and ritonavir ( RTV ) as a pharmacoenhancer of ATV was established.
Biofilm activity precipitously dropped when contacting orthodontic cement with DMAHDM.
Biofilm formation was also assessed by Live / Dead staining and scanning electron microscopy.
Biogenic amine turnover employs the enzymes and monoamine oxidase in neuronal and glial cells.
Biogerontology in Turkey has focused on general retardation of the aging process giving priority to caloric restriction and oxidative stress mechanisms.
Biogerontology is sometimes viewed as similar to other forms of biomedical research in that it seeks to understand and treat a pathological process.
Bioidentical recombinant human epidermal growth factor ( rhEGF ) is available in concentrations and purity suitable for therapeutic use in long time stable formulations.
Bioinformatic analysis allowed us to confirm the pathogenic role of the newly identified variant.
Bioinformatic analysis identified target sequences of the miR-29 family of miRNAs to be overrepresented in age-down-regulated genes.
Bioinformatics analyses of these genes have identified specific biological pathways that are up or downregulated in mature and old neurons.
Bioinformatics analysis of the cistrome revealed an enrichment of AP1 cis-regulatory motifs in the vicinity of the LXRβ-RXRα binding sites.
Bioinformatics analysis revealed that both circRNAs were potentially involved in glucose metabolism , mitotic cell cycle , and ovarian steroidogenesis.
Bioinformatics methods that leverage the vast amounts of clinical data promises to provide insights into underlying molecular mechanisms that help explain human physiological processes.
Bioinstrumentation measurements were taken , including corneometer , tewameter , ultrasound , and standardized digital imaging.
Biologic aging induces deficits in balance and muscle strength / power in old age , which is responsible for an increased prevalence of falls.
Biological aged-related passportization in a definite part of liquidators elucidated an accelerated aging rate.
Biological ages were computed using @number@ biomarkers measured in general health check-ups using an algorithm based on principal component analysis.
Biological aging is associated with a reduction in the reparative and regenerative potential in tissues and organs.
Biological aging is associated with physiological deteriorations , which are partly due to changes in the hormonal profile.
Biological aging is characterized by a chronic low-grade inflammation level.
Biological aging measures have been proposed as proxies for extension of healthy life span in trials of geroprotective therapies that aim to slow aging.
Biological aging rate appears to be age specific.
Biological alterations because of intrinsic or extrinsic stimuli can destabilize this perfectly organized system , thus effecting hair growth or metabolism.
Biological and epidemiological evidence has linked early-life psychosocial stress with late-life health , with inflammation as a potential mechanism.
Biological approaches to tendon repair that involve use of scaffolding materials or cell-based approaches are currently being investigated.
Biological assessments included CVD risk markers Interleukin-6 ( IL-6 ) and D-dimer.
Biological clocks play an important role in our emotions , cognitive function , and behavior.
Biological effects of the EGFR antagonists cetuximab and panitumumab and the MEK inhibitor UO126 on FDC-S cells were determined in vitro on FDC-AM09.
Biological fluid assessment represents a safer , cheaper and less invasive method compared to contrast imaging studies to predict NCD appearance.
Biologically active vitamin D , @number@ , 25-dihydroxylvitamin D3 , is synthesized in two distinct systems.
Biologically , EE is maintained within a narrow physiological range.
Biologically , these changes manifest as blunted immune responses , decreased bone marrow cellularity , and increased risk of myeloid diseases.
Biologically uncommon D-β-aspartic acid ( D-β-Asp ) residues have been reported to accumulate in organs affected by age-related disorders.
Biological mechanisms were examined in relation to the greater longevity of shorter people.
Biological micronutrient inadequacies have been mainly reported for zinc , selenium , iron , vitamin B12 and folate.
Biological reproducibility of biomarker levels over time and associations with routine biochemistry parameters were assessed by Spearman's correlation coefficients.
Biological samples were obtained and ADMA levels were determined using an enzyme immunoassay method.
Biological signals collected during CPX included : ventilatory and metabolic variables ; spectroscopy quasi-infrared rays - NIRS ; and HR through a cardio-frequency meter.
Biological significance and therapeutic implications of this study are discussed.
BIOLOGICAL SIGNIFICANCE : Induction of cellular senescence constitutes a potent concept for tumor therapy which interferes with immortalization and additional hallmarks of cancer.
BIOLOGICAL SIGNIFICANCE : Mutations in LMNA or defective processing of prelamin A causes premature aging disorders , including Hutchinson-Gilford progeria syndrome ( HGPS ) .
BIOLOGICAL SIGNIFICANCE : This study provides in-depth quantitative proteomic profiles of human glomeruli with intermediate and advanced sclerotic lesions.
Biological tests showed positive HCV and syphilis tests.
Biologic materials are stored in a central repository.
Biologic pigments have antioxidant and cytoprotective properties and should be considered as potential future therapies for disease and cancer.
Biologic prooxidants and physiologic loading have been proposed as potential mechanisms.
Biologics are associated with a small but significant overall risk of infections.
Biologists were asked to report quality data of recovered nucleic acids as well as PCR results.
Bioluminescence signals began to increase in 7-mo-old Tg ( CRND8 : Gfap-luc ) mice and 14-mo-old Tg ( APP23 : Gfap-luc ) mice.
Biomarker discovery studies and work on new diagnostic tests are both included.
Biomarker evidence was also integrated into the diagnostic formulations for probable and possible AD dementia for use in research settings.
Biomarker positive participants had more advanced cataracts and increased cortical light scattering , none of which reached statistical significance after adjustment for age.
Biomarker profiles could identify women at risk while also serving as indicators of efficacy of hormone therapy or other preventative interventions.
Biomarker research has investigated αS in blood , skin and cerebrospinal fluid ( CSF ) .
Biomarkers allow clinicians to show the presence of a pathologic process and resultant synapse dysfunction and neurodegeneration , even in the earliest stages.
Biomarkers are desperately needed for earlier diagnosis of AD and to monitor efficacy of new therapies.
Biomarkers assayed included inflammatory , coagulation , and endothelial function markers.
Biomarkers associated with Alzheimer's disease ( AD ) -like brain atrophy in healthy individuals may identify mechanisms involved in early stage AD.
Biomarkers correlated with immediate and delayed memory scores ( Pearson's @number@.26≤r≤0.32 , p≤0.05 ) .
Biomarkers enabling the preclinical identification of Alzheimer's disease ( AD ) remain one of the major unmet challenges in the field.
Biomarkers for cognitive impairment and decline were identified.
Biomarkers for the diagnosis of Alzheimer's disease ( AD ) are not yet validated for use in clinical settings.
Biomarkers have been studied extensively in atherosclerotic cardiovascular disease , with success as additive for clinical and scientific purposes.
Biomarkers included amyloid β42 , tau , and phosphorylated tau measured from cerebrospinal fluid and positron emission tomography measures of amyloid deposition.
Biomarkers indicating biological age are of significant interest for prevention , diagnosis and monitoring ( and the treatment ) of age-related diseases.
Biomarkers of AD were not available to define MCI attributable to AD.
Biomarkers of brain amyloidosis and neurodegeneration / synaptic dysfunction are featured in recent diagnostic criteria for Alzheimer's disease.
Biomarkers of this assay have been associated with increased risk for accelerated aging , cancer , and neurodegenerative diseases.
Biomarkers to evaluate ageing in HIV-infected patients are required.
Biomarker studies indicate that AD commences many years prior to clinical onset.
Biomarkers used in calculating the VACS Index were measured in prospectively collected blood samples using conventional laboratory methods.
Biomarkers were measured before and @number@ hours after PCI , and patients were followed up for @number@ year.
Biomarker values were trichotomized into positive for AD , negative , or borderline.
Biomaterial and pharmaceutical scientists continue to develop innovative strategies and materials to address this disease.
Biomechanical data collected from sit-to-walk phase of Timed Up and Go test were analyzed.
Biomedical and psychological factors showed a strong independent association with dizziness.
Biomembranes shown to behave like elastic sheets , can also suffer plastic deformations.
Biomimetic proteoglycans are synthesized by an end-on attachment of natural chondroitin sulfate bristles to a synthetic poly ( acryloyl chloride ) backbone.
Biomimetic simulation of the natural tooth microstructure might be a promising method.
Bio-prospecting of natural resources for anti-oxidants has hence been intensified.
Biopsies from the parietal area were processed for immunohistochemistry.
Biopsies were analysed at D0 , D5 and D10 and processed for immuno-histological staining specific to various dermal proteins.
Biopsies were examined in routine hematoxylin and eosin staining and immunohistochemistry to investigate expression of hTERT.
Biopsies were examined with real-time polymerase chain reaction technology and immunohistochemical techniques.
Biopsies were obtained from m. vastus lateralis before and after the immobilization period.
Biopsy histopathologic findings as well as demographic and laboratory data of the patients at the time of biopsy were gathered retrospectively from clinical records.
Biopsy in all cases showed foreign body-type granulomas.
Biopsy-related trauma induced LC migration from young epidermis , whereas in aged skin , migration was greatly reduced.
Biopsy samples were subjected to immunohistochemical staining and analysis of HA content.
Biopsy specimens from the PRP-treated side showed thicker collagen bundles than those from the control side.
Biopsy specimens obtained @number@ weeks after the second treatment and @number@ weeks after the fourth treatment were examined for histological study.
Biopsy specimens were taken @number@ h after the last irradiation.
Biopsy tissue was obtained at baseline , @number@ months , and @number@ months for immunohistochemical evaluation of neocollagenesis.
Biotinidase deficiency ( BD ) , which is caused by BTD genetic lesions , if untreated , can result in neurological and cutaneous manifestations.
Biotin supplementation can improve or prevent symptoms.
BioT may influence bone health through associations with muscle mass and bone area.
Biphasic gel has demonstrated deposition in big pools , often deep in the reticular dermis.
Biplot analyses were performed.
Bipolar disorder ( BD ) has been associated with impairments in a range of cognitive domains including attention , verbal learning , and mental flexibility.
Bipolar Disorder ( BD ) has been conceptualized as both a cyclic and a progressive disorder.
Bipolar disorder ( BD ) is a progressive psychiatric disorder characterized by recurrent changes of mood and is associated with cognitive decline.
Bipolar disorder is a chronic psychiatric illness characterised by fluctuation in mood state , with a relapsing and remitting course.
Bipolar disorder shows association with suicide risk for those with or without current episode.
Bipolar elders are disproportionately affected by medical burden.
Bipolar plasma vaporization is a promising technology , but its use in an office setting has not been completely evaluated yet.
Bipolar radiofrequency ( RF ) has been used to treat photodamage.
Birth cohorts from @number@ to @number@ were defined in 10-year birth-year intervals.
Birth cohort-specific probabilities of dying were calculated.
Birth cohorts were chosen a priori based on historical national trends in birth weights using 10-year increments.
Birth length / weight / BMI , and adult height / weight / BMI were also used as covariates , depending on the model.
Birth outcomes ( @number@ live births and @number@ stillbirths ) were ascertained from hospital records within @number@ hours of delivery.
Birth weight , HRQoL and social functioning were predictive of deficits in executive functioning.
Birth weight was significantly higher in GDM fetuses compared to normal pregnancies ( 3567±544 vs. 3253±370 g , P = 0.003 ) .
Bisexuals reported significantly greater problems with depression , anxiety , and suicidality than either heterosexual or lesbian or gay elders.
Bisphenol A ( BPA ) is a chemical used in plastic bottles and inner coating of beverage cans , and its exposure is almost ubiquitous.
Bisulfite-sequencing PCR ( BSP ) was performed to evaluate the methylation status of CpG islands near OGG1 in DNA extracted from lens cortex.
Bitumen extraction from the oil sands of northern Alberta produces large volumes of process-affected water that contains substances toxic to wildlife.
Bivalent chromosomes are stabilized by cohesion between sister chromatids , which is mediated by the cohesin complex.
Bivariate analyses ( controlling for chronological age ) identified and quantified lifestyle variables associated with perceived facial age.
Bivariate analyses examined age-related differences in psychosocial experiences and reincarceration between younger and older participants.
Bivariate analyses indicated that Perceived Cognitive Impairment was associated with increased health problems , mobility limitations , depressed mood , and lower social functioning.
Bivariate analyses were conducted using the Rao-Scott Chi-square test to examine associations between PAD and sociodemographic variables.
Bivariate analysis and generalized estimation equations ( GEE ) were used.
Bivariate analysis and multivariate logistic regression were employed to isolate the independent effects of race / ethnicity on LTCI uptake.
Bivariate analysis determined variables associated with 3-mRS for inclusion in ordinal multivariate analysis.
Bivariate analysis revealed that PI was significantly correlated to both apathy ( p = 0.018 ) and depression ( p = 0.014 ) .
Bivariate analysis was conducted between accessibility to health facilities and prevalence of the diseases.
Bivariate analysis was conducted between survivors and deceased.
Bivariate and logistic regression analyses were employed to evaluate differences between cases and controls.
Bivariate and logistic regression analyses were used to assess the association between elder abuse and different definitions of metabolic syndromes.
Bivariate and multiple regression analyses were performed to examine the association of socioeconomic factors and consumption of animal-source foods with height.
Bivariate and multivariate analyses were conducted to examine how the identified social network typology was associated with self-rating of health and depressive symptoms.
Bivariate and multivariate logistic regressions were used to identify predictors of new VESC.
Bivariate associations of frailty with health and function measures were evaluated by chi-squared test and analysis of variance.
Bivariate associations were analyzed using chi-squared tests , t tests , and median tests , and multivariable associations were assessed using logistic regression.
Bivariate associations were described using odds ratio ( OR ) with @percent@ confidence intervals ( CI ) .
Bivariate associations were quantified using Spearman's rank correlation coefficients.
Bivariate Box-Cox regression models compared cytokine levels between immature and mature groups.
Bivariate Cholesky decomposition was used for longitudinal analysis.
Bivariate correlations and hierarchical regressions were completed to determine the association between CR and FA.
Bivariate correlations were conducted.
Bivariate dual-change score models were fit to examine the dynamic association between anxiety and cognitive performance.
Bivariate meta-analyses were used to derive summary estimates of overall sensitivity and specificity of individual and joint application of both tests.
Bivariate or ordinal logistic regression models were used to investigate the relationship of age , health and partner status to sexual frequency and experience.
Bivariate statistical methods were used to analyse the effects of gender , age and height on these measurements.
Bivariate statistics and logistic regressions were calculated to evaluate which demographic or NPI subscale symptoms predicted medication use.
Bivariate statistics determined whether there were significant differences between MST measures or food intake within subjects.
Bivariate twin models were fitted to estimate the genetic and environmental correlation between physical and cognitive function.
Bivariate twin models were fitted to quantify the genetic and environmental components of the correlations between hearing and cognitive functions.
B-K fusion resulted in similarly significant favorable PFS for patients who received chemotherapy.
Black and green tea gels were tested in vivo in the forearms of six subjects using an artifical UV ( 200-400 nm ) source.
Black males had significantly better high-frequency hearing compared with white male counterparts but significantly worse low-frequency hearing.
Black men had the highest and white women the lowest age-related MAWT increase.
Black middle-aged adults provided more support to parents than White middle-aged adults.
Black participants had better oVEMP function ( shorter latency , increased amplitude , and decreased odds of absent responses ) relative to white participants.
Black race and Hispanic ethnicity were associated with greater BMI and WC.
Black respondents more commonly attributed their symptoms to personal behaviors over which they had control and therefore did not require medical care.
Blacks also had a higher likelihood of transitioning from nondepressed to death ( OR : @number@ @percent@ CI : @number@ @date@ ) .
Blacks and women were more likely to be identified with dysglycemia by A1c than FPG.
Blacks generally had a later age of onset of alcohol problems.
Blacks had higher initial HbA1c values compared with Whites and Hispanics , but a similar rate of deterioration.
Blacks have on average lower plasma aldosterone concentrations ( PACs ) than Whites.
Black soy peptide dietary supplementation significantly reduces SBP and oxidative stress in patients with prehypertension and stage I hypertension.
Black soy peptides have been shown to possess properties that may decrease blood pressure ( BP ) .
Black specimens had more convex morphology at L4 and L5.
Blacks were more likely than whites to report disability ( odds ratio = 1.39 , @percent@ confidence interval = @number@ @date@ ) .
Black women had the highest weighted mean age-standardized prevalence ( @percent@ ; @percent@ CI @date@ @number@ ) .
Black Young adults reported sleep durations similar to those of White young adults until age @number@ after which blacks slept less than whites.
Bladder cancer is a common cause of morbidity and mortality worldwide in an aging population.
Bladder cancer of the urothelium is the second most common malignancy among urological tumors.
Bladder dysfunction due to detrusor instability ( caused by old age ) is considered to be associated with chronic ischaemia and inflammation.
Bladder problems are frequently disorders of control , which is exercised from the brain.
Bladder tamponade is thought to be caused mainly by bladder cancer or radiation cystitis.
Blade tenderized steaks had higher cook loss than C steaks.
Bland-Altman analyses also demonstrated good agreement between the testing days with a small mean difference @number@ ( @number@ @number@ ) .
Bland-Altman analysis demonstrated similar bias for both cFT and RIA , although cFT consistently overestimated FT.
Bland-Altman analysis was used to assess the clinical agreement between the two instruments.
Blanket prophylaxis efforts have not appreciably decreased incidence , making targeted prevention for high-risk patients desirable.
Blast-exposed mice demonstrated phosphorylated tauopathy , myelinated axonopathy , microvasculopathy , chronic neuroinflammation , and neurodegeneration in the absence of macroscopic tissue damage or hemorrhage.
Blast exposure is associated with traumatic brain injury ( TBI ) , neuropsychiatric symptoms , and long-term cognitive disability.
BLBP ( + ) NSCs are mitotically active components of pinwheel structures in the lateral ventricle walls and persistently generate neurons in adulthood.
Bleaching alters the enamel surface and the resin / enamel interface , but it does not influence bond strength.
Bleeding has been a concern since the introduction of SSRIs , with multiple case reports published and communicated to the pharmacovigilance systems.
Bleeding often associated with excessive antithrombotic drug dosing is a major concern.
Blepharoplasty is one of the most popular and common procedures in facial plastic surgery.
Blepharoplasty of the upper eyelids is one of the most commonly performed procedures in aesthetic plastic surgery.
Blepharoplasty techniques include both the transcutaneous skin-muscle flap as well as the transconjunctival approach.
Blepharoptosis of the upper eyelid is a common condition among patients presenting for oculoplastic surgery.
Blinded assessments of subjects were performed at each visit under ambient and Wood's light.
Blinded assessments revealed that @percent@ to @percent@ of subjects maintained WSRS scores of @number@ point or more higher than baseline throughout the study.
Blinded data collectors measured follow-up exercise behaviour and functional outcomes at 3-month intervals.
Blinded evaluators rated Wrinkle Severity Rating Scale ( WSRS ) results as \ "identical \ " in @percent@ of patients.
Blinded listeners rated the posttreatment voices as significantly less breathy and strained.
Blinded photographic assessment of overall improvement , rhytides , skin texture , dyspigmentation , and telangiectasia was performed.
Blinded photographic assessments and spectrophotometric analysis revealed no statistical improvement in skin laxity.
Blinded photographs were independently scored for wrinkle improvement.
Blinded physician evaluators and patient self-evaluators clinically and photographically assessed responses during standard intervals over @number@ months.
Blinded randomisation was performed by the pharmacy ; all participants , researchers performing the measurements and those assessing study outcomes were blinded.
Blinded reviewers interpreted CA to determine the IRA and CMR to determine the location of infarction on a 17-segment model.
Blinded reviewers observed improvement in skin laxity in @percent@ of patients.
Blinding of participants was not possible.
Blinding was maintained throughout the study , for both the evaluator and participants.
Blindness prevalence was @percent@ ( confidence interval of 95% : @number@.5-2.5% ) .
BLM expression from the native SGS1 promoter had no adverse effects on cell growth and was unable to complement any sgs1Δ defects.
BLM mRNA overexpression was associated with poor breast cancer-specific survival ( BCSS ; ps < @number@ ) .
BLM overexpression , however , significantly increased the rate of accumulating gross-chromosomal rearrangements in a dosage-dependent manner and greatly exacerbated sensitivity to DNA-damaging agents.
BLM protein level was evaluated in the Nottingham Tenovus series comprising @number@ breast tumors.
Blockade of IL-1β actions by IL-1 receptor antagonist largely prevents the deleterious effects of CCN1 on collagen homeostasis.
Blockade of interleukin ( IL ) -6 ( tocilizumab ) and IL-1 ( gevokizumab ) are being evaluated in phase III clinical trials.
Blockade of PKC-beta strikingly decreased HUVEC TGF-beta1 and ICAM-1 expression in both protein and mRNA levels , RAGE protein level was also down-regulated.
Blockade of the vasopressin-2 receptor ( @date@ in the kidney has recently emerged as a promising therapeutic strategy in autosomal dominant polycystic kidney disease.
Blockage of BLT2 via siRNA knockdown or with the BLT2-antagonist LY255283 completely abolished the up-regulated expression of MMP-1 induced by low-dose UVB irradiation.
Blockage of caspase activation through treatment with a pan-caspase inhibitor consistently inhibited apoptosis and abrogated growth inhibition in DATS-treated T24 cells.
Blocking IL-6 trans-signaling in the CNS abrogates the ability of IL-6 to suppress feeding.
Blocking mTOR with rapamycin and first generation mTOR inhibitors , called rapalogs , has shown promising reduction of HCC tumor growth in preclinical models.
Blocking of miR-126 function increased IGF-1 trophism and neuroprotection to 6-OHDA.
Blocking RelB expression prevented the increase in the expression of beta1 integrin and the attachment of H69.
Blocking this pathway with several inhibitors inhibited hSKP proliferation and sphere formation and increased hSKP senescence.
Blocks were bonded to composite using Clearfil Esthetic cement.
Blocks were performed using nerve stimulation and @percent@ ropivacaine.
Blockwise multiple regressions indicated that the APOE ϵ4 predicted positive but not negative affect after controlling for demographics.
B. longum group was widely detected from newborns to centenarians , with the highest detection rate.
Blood and arterial tissue telomere lengths were determined by Southern blotting.
Blood and expired air samples were taken before and at 2-h intervals during the 8-h postprandial period.
Blood and lymphatic vessels were highlighted by Ulex europaeus agglutinin-1 and human podoplanin immunoreactivities , respectively.
Blood and muscle amino acid concentrations and basal and postexercise muscle protein turnover were measured by using stable isotopic methods.
Blood and muscle tissue samples were collected to measure systemic hormone and amino acid concentrations , tracer enrichments , and myofibrillar protein synthesis.
Blood and @number@ h urine samples were also collected from seventy-six of the volunteers for the analysis of biomarkers of nutrient intake.
Blood and saliva samples were collected at days @number@ @number@ and @number@ for measurements of innate immune parameters.
Blood-based bioenergetic profiling is also associated with gait speed and may provide an alternative measure of mitochondrial function.
Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased patient acceptance.
Blood-based markers reflecting core pathological features of Alzheimer's disease ( AD ) in pre-symptomatic individuals are likely to accelerate the development of disease-modifying treatments.
Blood biomarkers for osteoporosis , as well as diurnal rhythms of cortisol levels were used as cognitive performance correlation parameters in linear multivariate regression analyses.
Blood biomarkers , including serum lipid , lipoprotein cholesterol , serum albumin , and lymphocyte count , were correlated with activities of daily living.
Blood-brain barrier ( BBB ) dysfunction might be an important component of many neurodegenerative disorders.
Blood concentration of ferritin was measured at baseline in @date@ .
Blood concentrations and urinary excretion of hydroxyproline ( OH-PRO ) have been used as markers of bone mineral status and lung function in CF.
Blood DNA methylation was assessed using the Illumina Human Methylation @number@ BeadChip.
Blood flow rate ( BFR ) in @number@ intra- and extracerebral arteries was measured.
Blood flow rate in cerebral arteries decreased with increasing age ( P < 0.05 ) but not in extracerebral arteries.
Blood glucose , basal insulin , and homeostatic model assessment of insulin resistance were also significantly reduced ( P < 0.01 ) .
Blood glucose levels in the glucagon-like peptide-1 group were better controlled with much less variability.
Blood hemoglobin concentration was assessed at the start and end of the intervention.
Blood is a matrix with high potential for forensic investigations and human rescue.
Blood is a tissue with high cellular turnover , and its production is a tightly orchestrated process that requires constant replenishment.
Blood lactate was measured at baseline , immediate post , and 20-min post each TTE.
Blood lead levels were evaluated using Varian AA 240Z atomic absorption spectrophotometry.
Blood lead levels were strong , positively correlated with urinary deoxypyridinoline.
Blood levels of docosahexaenoic acid , eicosapentaenoic acid , vitamin D , and cholesterol were measured in a subsample ( n = @number@ ) .
Blood loss was significantly greater with arthroplasty ( 311±197mL versus 201±165mL , P < 0.0002 ) .
Blood measure was recorded via a mercury column sphygmomanometer.
Blood oxygenation level-dependent ( BOLD ) signal changes are often assumed to directly reflect neural activity changes.
Blood oxygen level-dependent functional magnetic resonance imaging was collected during the performance of a visuospatial distance judgment task with three parametric levels of difficulty.
Blood plasma was filtered using the hybrid material to evaluate the protein removal percentage and the lifetime of the hybrid material in vitro.
Blood pressure and age were closely related with aortic arterial stiffness.
Blood pressure and anthropometric measurements were taken at participants ' homes.
Blood pressure and APOE genotype were assessed at baseline.
Blood pressure and resting heart rate were also studied.
Blood pressure , body mass index , use of medications , and history of CVD were also assessed.
Blood pressure ( BP ) changes with age.
Blood pressure ( BP ) is a heritable , quantitative trait with intraindividual variability and susceptibility to measurement error.
Blood pressure ( BP ) , lipid profile and glycaemia were assessed at baseline and monthly for all the patients.
Blood pressure ( BPs ) of four limbs was simultaneously measured with @number@ electronic sphygmomanometers after @number@ min rest in supine position.
Blood pressure ( BP ) was measured at baseline.
Blood pressure ( BP ) was monitored intermittently.
Blood pressure change between those without amnesia and those with amnesia showed no significant difference ( P = 0.687 ) .
Blood pressure increased significantly and substantially during the BFR session.
Blood pressure , lipid profile , and C-reactive protein and hemoglobin concentrations were not associated with survival.
Blood pressure means of adult age groups were modeled by linear and polynomial regression.
Blood pressure measures and self-reported hypertension history were collected at baseline , @number@ years and @number@ years later.
Blood pressure naturally rises with increasing age.
Blood pressures and total peripheral resistance were equal.
Blood pressures , waist circumferences , serum levels of fasting blood glucose , high density lipoprotein and triglyceride of patients were recorded.
Blood pressure was measured categorically as ' Hypertension ' and continuously as ' Mean Arterial Pressure ' ( MAP ) .
Blood pressure was measured every three months during an average of @number@ years.
Blood pressure was measured simultaneously at the right arm.
Blood pressure was measured with the use of digital monitors ( Omron MS - @number@ Basic Model ) .
Blood pressure was similar for men and women with a combined hypertension prevalence of @percent@ and statistically significant increases were observed with increasing age.
Blood products derived from iPS cells have been pursued as a blood donor-independent and genetically manipulative measure to complement or alternate current transfusion products.
Blood samples and self-reported medication data were collected.
Blood samples and waist circumference were examined to identify metabolic syndrome according to the criteria set forth in the @number@ Joint Scientific Statement.
Blood samples from all subjects were collected to measure the nutrient biomarkers.
Blood samples from all the women were examined for hematological , rheological , and biochemical parameters prior to the study and five months thereafter.
Blood samples from @number@ AD patients and @number@ age-matched controls were analysed for HLA-type , CMV serostatus and systemic inflammatory biomarkers.
Blood samples were also taken from the injured elderly group within @number@ hours of trauma and subsequently at two periods during their hospital stay.
Blood samples were analysed for concentrations of T and calculations were made for BT.
Blood samples were analyzed for lipid profile , DNA damage and malondialdehyde ( MDA ) .
Blood samples were collected after 12-hour fasting for the measurement of total cholesterol , triglycerides and fasting glucose levels.
Blood samples were collected after informed consent was given.
Blood samples were collected at day @number@ day @number@ day @number@ and day @number@
Blood samples were collected at rest , after warm-up , immediately post-WAnT , and @number@ min post-WAnT.
Blood samples were collected before training and @number@ h after completion of the @number@ sessions for the determination of serum IL-6 and TNF-α levels.
Blood samples were collected for C-reactive protein ( CRP ) , tumor necrosis factor , and interleukin-6 ( IL-6 ) measurements.
Blood samples were collected for determination of serum levels of retinol and zinc.
Blood samples were collected for genetic evaluations and for plasma caffeine and catecholamines measures.
Blood samples were collected from HIV-positive participants 7-11 years after ART initiation.
Blood samples were collected from @number@ adults at four weekly sampling intervals and were quantified using a high-sensitivity immunoassay.
Blood samples were collected from @number@ individuals between @number@ and @number@ years of age.
Blood samples were collected from rats at @time@ and from patients with PD and healthy subjects between 8 : 00 and @time@ .
Blood samples were collected in 1989-1990 ( Nurses ' Health Study ) and 2000-2002 ( ESTHER ) .
Blood samples were collected to evaluate testosterone levels.
Blood samples were collected to identify CVD risk factors.
Blood samples were drawn by medical practitioner and lymphocytes were isolated from blood samples.
Blood samples were irradiated with curative and palliative doses of @number@ Gy or @number@ Gy γ-rays.
Blood samples were obtained at baseline ( time @number@ ) , end of month @number@ and month @number@
Blood samples were obtained from all study participants at @number@ h and @number@ days post-PCI.
Blood samples were obtained from @number@ patients and @number@ controls.
Blood samples were obtained in a Dutch cross sectional observational study from symptomatic pertussis cases.
Blood samples were subsequently used for PCR assay to detect T. gondii DNA ( gra6 ) .
Blood samples were taken at baseline , after @number@ days of BR and @number@ days of recovery.
Blood samples were taken for pharmacokinetic analysis up to @number@ h post-dose.
Blood samples were taken from each patient before procedure and at @number@ @number@ @number@ and @number@ minutes after procedures.
Blood samples were taken from @number@ stable COPD patients.
Blood samples were taken in the fasted state and for @number@ h post-OGTT.
Blood sample was collected to obtain the lipid fractions , and the weight , height , waist circumference and body fat percentage were measured.
Blood sampling were drowned from all physicians during their working hours for analysis of telomere length , markers of oxidative stress.
Blood test results and other clinical data were retrieved from the electronic medical records.
Blood tests were performed on @number@ subjects of whom @number@ also had extended biomarker assessment.
Blood thiamine and its derivatives were quantified using HPLC.
Blood TLR2 methylation was analyzed using pyrosequencing.
Blood toxicity and biochemical values were studied in @number@ patients of different age with ischemic heart disease.
Blood transfusion data were obtained retrospectively via the Trust blood bank electronic records.
Blood vessels are often overlooked in analyses of skeletal muscle biopsies.
Blood vessels stained positively for angiomotin were detected in skin samples in all ages.
Blood vessels then recede , perhaps due to increasing mechanical stresses in the surrounding matrix.
Blood vessels were seen within the cartilage with differences across age groups.
Blood vessels were visualized with immunohistochemical technique to two endothelial markers , as von Willebrand factor and antigen CD31.
Blood was collected for analysis of 25 ( OH ) D by high-performance liquid chromatography.
Blood was drawn between breakfast and lunch.
Blood was taken from AD and non-Alzheimer's dementia patients , aged-matched and younger controls.
Bloom's syndrome ( BS ) and Fanconi anemia ( FA ) are autosomal recessive disorders characterized by cancer and chromosomal instability.
Bloom syndrome helicase ( BLM ) has key roles in homologous recombination repair , telomere maintenance , and DNA replication.
BlotGlycoABC ( TM ) , an integrated glycoblotting technique for rapid and large scale clinical glycomics.
BLSA is a representative cohort study from @number@ to @number@ hosted by Xuan Wu Hospital.
BLS training should be modified to help the elderly gain confidence with the essential elements of BLS , including making early emergency calls.
Blueberries can eradicate microorganisms for the prevention of symptomatic urinary tract infections in women.
Blue-collar workers had earlier mean ANM than white-collar workers.
Blue light , which is particularly beneficial during the daytime , seems to be more disruptive at night , and induces the strongest melatonin inhibition.
Blue zones are mysterious regions that continue to attract research.
B lymphocytes are also impaired in the elderly in terms of their response to new antigens.
B lymphocytes are essential elements of the immune system responsible for antibody production.
B-lymphocytes undergo isotype switching , and IgM , IgG , and IgA antibodies are found in the neuropil adjacent to the lesion.
BMAD values of the WB , L2-L4 , FN and @date@ radius were calculated.
BM-A progressively increase with aging , eventually occupying up to @percent@ of BM cavities.
[ BMB reports @number@ 44 ( @number@ ) : 298-305 ] .
[ BMB Reports @number@ 49 ( @number@ ) : 671-680 ] .
[ BMB Reports @number@ 50 ( @number@ ) : 164-174 ] .
[ BMB Reports @number@ 50 ( @number@ ) : 269-274 ] .
[ BMB Reports @number@ 50 ( @number@ ) : 345-354 ] .
[ BMB Reports @number@ 50 ( @number@ ) : 43-48 ] .
BMDACs have a significant survival advantage under conditions of low O ( @number@ ) and low pH ex vivo and in ischemic tissue.
BMD and body composition values were measured by using DEXA.
BMD and body composition were estimated using dual-energy X-ray absorptiometry with fan-beam technology.
BMD and cortical and trabecular micro-architecture were measured and biomechanical parameters were estimated using micro finite element analysis ( μFEA ) .
BMD at the total hip , femoral neck , and lumbar spine was assessed via dual-energy X-ray absorptiometry at baseline and @number@ months.
BMDM dysregulation in aging impairs the expression levels of pro-inflammatory cytokines and genes involved in B-cell maturation and activation.
BMD measurements were obtained using dual-energy X-ray absorptiometry instrumentation.
BMD of lumbar spine and femoral neck was assessed by dual-energy X-ray absorptiometry twice at 6-year intervals.
BMD of lumbar spine and left femur was also evaluated by dual energy X-ray absorptiometry.
BMD of the hip and spine was measured by dual X-ray absorptiometry.
BMD was measured at lumbar spines using DXA.
BMD was measured at the nondominant radius by dual-energy X-ray absorptiometry.
BMD was measured by dual-energy radiograph absorptiometry at lumbar spine.
BMD Z-scores and total BMD ( g / cm2 ) of the spine were significantly higher in the growth hormone group.
BMI ≤20 percentile was associated with a large drop in fat-free mass , a reduced FEV ( @number@ ) , and in bone mineral loss.
BMI and biceps skinfold measurements were lower in the lowest IGF-I quartile in men aged > or = 75.5 years.
BMI and cardiometabolic factors together explained @percent@ of the diabetes-associated odds of disability at 12years.
BMI and FM were higher among older age groups compared with the younger ones.
BMI and thigh IMAT area ( independent of BMI ) were particularly strong indicators of incident mobility limitation and poor performance.
BMI and VAT attenuated this relationship , providing insight into the potential metabolic role of liver fat in brain health and disease.
BMI and waist girth were moderately correlated with the arm , leg , trunk and total fat and weakly with VAT , IHL and IMCL.
BMI and WHR did not show significant independent association with mortality in the main analysis.
BMI appears to become more relevant at later stages of the disease.
BMI became significantly associated with both inflammatory markers after @number@ year , showing higher levels with increasing weight.
( BMI @date@ @number@ was the reference. )
BMI decreases with age reflect increased frailty , especially among older adults with complex morbidities.
BMI did not differ significantly between the two matched samples.
BMI does not distinguish between lean and fat mass and in children , the cross-sectional relationship between %BF and BMI changes with age and sex.
BMI even increased ( b = 0.11 , p = 0.004 ) among prevalent AD participants in NACC.
BMI has an impact on both arch height and stiffness.
BMI has no influence on nerve excitability data and does not explain sex-related differences in threshold.
BMI in early adulthood has important implications for cardiometabolic health , even within young , physically active populations.
BMI ( kg / m RESULTS : During a mean follow-up period of @number@ years , @number@ men and @number@ women died.
BMI may be a less appropriate index in the elderly.
BMI-mortality curves were drawn to find the optimal BMI range with the lowest mortality.
BMI of all subjects decreased gradually and as the BMI decreased , glucose , HbA1c , insulin , Homa-IR and TSH levels were decreased.
BMI of around @number@ ( @date@ @number@ ) is associated with the lowest risk of prevalence of possible dementia and the highest cognitive function scores.
BMI percentile of @number@ should be considered as the new critical threshold for nutritional failure in CF if body composition techniques are not available.
BM is a major cause of morbidity and mortality affecting neurocognition , speech , coordination , behavior , and quality of life.
BMI , sun exposure and skincare were associated predominantly with perceived facial age via wrinkling , whereas oral care was associated via other facial features.
BMI was associated with counts of lactobacilli , adjusted for age and sex ( P = 0·008 ) .
BMI was calculated , and patients with a BMI of @number@ kg / m ( @number@ ) or greater were considered obese.
BMI was calculated as body weight ( kg ) divided by the square of height ( m ) .
BMI was calculated using the actual height and the tallest height of each study participant. %BF was compared with BMI and stratified for age.
BMI was determined from measured height and weight.
BMI was negatively associated with all the physical subscales of SF-36 ( p < @number@ ) .
BMI was non-significantly related to FF quantification.
BMI was not associated with any outcomes in adjusted models.
BMI was not statistically significantly different between both groups.
BMI was positively associated with performing sedentary activities ( r = 0.188 ; p < 0.001 ) .
BMI was positively correlated with atrial enlargement in a statistically significant way even after multiple adjustments.
BMI was positively correlated with leptin and triglyceride levels.
BMI was positively related to basal secretion.
BMI was thus removed to promote feasibility.
BMIz was measured at baseline , @number@ months and @number@ year in @number@ urban schoolchildren , ages 9-15 years.
BMLs may be important surrogate targets for monitoring pain and structure modification in OA therapeutics.
BMLs were graded according to the whole-organ MRI score.
BMLs were significantly linked to knee pain , and BML severity correlated with knee pain severity.
BM mean value was around @number@ μm , with narrow limits of ranging in AgGr but more extended individual limits.
BM-resident memory T cells produce more IFN-γ and are frequently polyfunctional.
BMSCs may be sensitive to age-related diseases and could perpetuate degenerative diseases in which bone remodeling is a contributory factor.
BN analysis demonstrated heterogeneous regional convergence degree across DMN regions , which were organized into two closely interacting subsystems.
BNIP3 and NIX have an emerging role in human health.
BNIP3 downregulates mitochondrial mass in hypoxic cells , whereas NIX is required for mitochondrial elimination during erythroid development.
BNP level was higher in women than that in men in groups I and II.
BN predictions were more accurate for both FFM and FM than those obtained from linear models.
B = @number@ p ≤ @number@ ) .
B = @number@ p ≤ @number@ ) .
B = @number@ p ≤ @number@ psychosocial unstd.
B = @number@ p ≤ @number@ pyschosocial unstd.
Body acceptance by others mediated the social support-body appreciation and BMI-body appreciation links.
Body and muscle composition were estimated by bioimpedance and computed tomography , respectively.
Body angle was shown to increase with age ( p = @number@ ) .
Body appreciation and resistance to adopt an observer's perspective mediated the body acceptance by others-intuitive eating link.
Body composition and BMD of total body , lumbar spine , total hip and femoral neck were measured using DXA.
Body composition and bone mineral density ( BMD ) measurements were performed using Dual-energy X-ray absorptiometry methodology ( DXA ) .
Body composition and bone mineral density ( BMD ) were assessed by dual-energy X-ray absorptiometry ( DXA ) .
Body composition and bone mineral density were measured by dual X-ray absorptiometry.
Body composition and fat mass were measured using computed tomography and dual energy X-ray absorptiometry ( DXA ) .
Body composition and isokinetic strength were assessed before and after the exercise program.
Body composition and muscle function have important implications for falls and fractures in older adults.
Body composition and performance were better in users than non-users.
Body composition and physical fitness were measured at baseline , after nine months of training and after three months of detraining every year.
Body composition ( assessed by dual energy X-ray absorptiometry ; DXA ) , anthropometric parameters and adiponectin were obtained from all participants.
Body composition data from a female reference group ( n = @number@ mean age @number@ years ) provided cut-off values for defining sarcopenia.
Body composition ( dual energy X-ray absorptiometry ) and knee extension strength of the right leg ( @number@ repetition maximum ) were assessed.
Body composition ( dual energy X-ray absorptiometry ) , handgrip , and knee extension strength were assessed.
Body composition of the trunk , upper limbs and lower limbs was measured by bio-impedance analysis.
Body composition parameters ( body weight , fat mass , and appendicular skeletal muscle mass ) were measured with a bioelectrical impedance analyser.
Body composition , short performance battery test , aerobic fitness and muscle strength were assessed.
Body composition , skeletal muscle strength , and peak oxygen uptake were measured before and after the intervention.
Body compositions were assessed via bioelectrical impedance analysis ( BIA ) .
Body composition techniques may be used to study ageing process.
Body composition , total blood volume , and heart rate recovery after maximal exercise were also examined.
Body composition , upper- and lower-limb strength level , and QoL were assessed.
Body composition was assessed at baseline and 6-year follow-up by dual-energy x-ray absorptiometry.
Body composition was assessed by DEXA.
Body composition was assessed by dual-energy X-ray absorptiometry and maximum strength was evaluated using isometric techniques for trunk and legs.
Body composition was assessed by DXA and BIA.
Body composition was assessed using dual energy x-ray absorptiometry.
Body composition was assessed using dual-energy x-ray absorptiometry.
Body composition was assessed using dual-energy X-ray absorptiometry analyses.
Body composition was assessed with DXA methodology.
Body composition was categorized as SO , sarcopenic nonobesity , nonsarcopenic obesity , and nonsarcopenic nonobesity.
Body composition was determined by bioelectrical impedance analysis.
Body composition was determined by dual energy X-ray absorptiometry ( DXA ) .
Body composition was determined in 1995-1996 by dual energy X-ray absorptiometry.
Body composition was evaluated by dual-energy x-ray absorptiometry.
Body composition was measured by bioelectrical impedance.
Body composition was measured by bioelectrical impedance analysis , and skeletal muscle mass was estimated by Janssen's equation.
Body composition was measured by dual-energy X-ray absorptiometry.
Body composition was measured by dual X-ray absorptiometry and REE by indirect calorimetry.
Body composition was measured by DXA ( Lunar Prodigy ) to acquire total body and total body less head ( TBLH ) measures.
Body composition was measured through bioimpedance analysis.
Body composition was measured using Dual Energy X ray Absorptimetry ( DXA ) .
Body composition was measured with DXA.
Body fat content , fat distribution and protein nutrition state parameters were assessed by means of anthropometry.
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes , independent of overall adiposity.
Body fat mass alterations , of multifactorial causes , continue to occur , despite use of antiretroviral drugs associated with fewer metabolic side-effects.
Body fat percentage ( %BF ) was determined using DEXA ( dual energy X-ray absorptiometry ) .
Body fat percentage ( BF% ) was measured by bioelectrical impedance.
Body fat was measured using bioelectrical impedance.
Body hair loss was significantly correlated with older age ( P < 0·001 ) and was most frequent at androgen-sensitive sites.
Body heat storage was calculated as the temporal summation of heat production and total heat loss over the experimental session.
Body heat storage was measured as the temporal summation of heat production and loss.
Body image can be negatively impacted by oral conditions , particularly those that are appearance related and do not meet cultural ideals.
Body kinematics and ground reaction forces were obtained both before and after the exercises , and joint torques were derived via inverse dynamics.
Body kinematics , electromyographic activity of @number@ muscles , and ground reaction forces were analyzed during the anticipatory and compensatory phases of postural control.
Body kinematics were collected during treadmill walking , and gait characteristics were assessed using spatial-temporal gait parameters.
Body mass index and health history were also assessed.
Body mass index at the time of surgery was @number@
Body mass index ( BMI ) > 30 or < 18 kg / m2 were excluded.
Body mass index ( BMI ) and handgrip strength ( HGS ) were also performed to assess other aspects of nutrition.
Body mass index ( BMI ) and mortality in old adults from the general population have been related in a U-shaped or J-shaped curve.
Body mass index ( BMI ) and waist circumference ( WC ) were measured @number@ years earlier ( @number@ ) .
Body mass index ( BMI ) and waist circumference were reported as measures of body composition.
Body mass index ( BMI ) and waist-to-height ratio ( WHtR ) were calculated based on clinical examinations.
Body mass index ( BMI ) , CNR , and ECV / TBW differed significantly between age groups , and genders.
Body Mass Index ( BMI ) cut-off values for Asians were used to categorize the subjects according to weight status.
Body mass index ( BMI ) , DHT / TT and E2 / TT were calculated.
Body mass index ( BMI ) , grip strength , quadriceps torque , and walking speed were assessed using physical examination and performance testing.
Body mass index ( BMI ) , waist circumference and demographic details were recorded.
Body Mass Index ( BMI ) , waist circumference ( WC ) , prostate volume , and prostate specific antigen ( PSA ) were recorded.
Body mass index ( BMI ) was calculated as body weight ( km ) divided by the square of height ( m ) .
Body mass index ( BMI ) was calculated as outlined by the Centers for Disease Control and Prevention based on self-reported height and weight.
Body mass index ( BMI ) was calculated from self-reported height / weight.
Body mass index ( BMI ) was negatively associated with ' free from OA' , and also with absence of hip and knee OA.
Body mass index did not change during the observation period.
Body mass index explained the largest proportion of AF risk.
Body mass index , fat free mass , or body fat was not a significant covariate and did not influence the results.
Body mass index measures were used to categorize older adults into under / normal weight , overweight , and obese groups.
Body mass index , percent fat , and waist circumference tended to be elevated.
Body Mass Index / serum ferritin correlation was not statistically significant ( Pearson's r = @number@ ) .
Body mass index was calculated from measured height and weight.
Body mass index was compared to the general US population , adjusted for age , gender , Tanner stage and race.
Body mass index was obtained before and after @number@ weeks.
Body mass of males but not females correlated positively with fGCM in the dry season.
Body posture and activity are important indices for assessing health and quality of life , especially for elderly people.
Body satisfaction was associated with better overall functioning.
Body structures and functions were marginally impaired , whereas environmental factors and psychosocial issues had a relevant impact on quality of life.
Body surface measurements are used to determine the distance traveled by the pulse wave between the two sampling sites.
Body sway velocity and ability to perform the activities of daily living are the best predictors of recurrent falls.
Body sway was assessed by median absolute deviation ( MAD ) of anterior-posterior translation of the center of mass ( COM ) .
Body temperature measured by tympanal and temporal artery thermometry was correlated with rectal thermometry.
Body temperature was determined by tympanal thermometry , temporal artery thermometry and rectal temperature measurement.
Body water initially enriched at @number@ @date@ APE decayed at ~0.009% / day.
Body weight accounted for @percent@ of the variance in the data ( adjusted R ( @number@ ) = 0.72 ) .
Body weight and hypoglycaemic episodes were also recorded.
Body weight assessment with specific attention to unintended weight loss is essential in this evaluation.
Body weight ( BW ) , height ( H ) and the BMI were measured according to the international standards.
Body weight decreased in CR ( @number@ ± @number@ kg ) , but not AL ( @number@ ± @number@ kg ) .
Body weight , height and SBP were measured.
Body weight increased the risk for BMLs to a lesser extent.
Body weight , O2 extraction , the capillary pulse , blood pressure and the surface of the ulcers were monitored.
Body weight remained unchanged.
Body weight was measured biannually with the last visit occurring between @number@ and @number@
Body weight was measured during baseline and follow-up ( 7-106 days after baseline ) .
Bodyweight was modeled to determine the predictors and distribution of the expected trajectory of percent weight change over @number@ months of CR.
Body weight was updated at a total of six time points during follow-up.
Bolivian immigrants in Brazil experience serious social problems : precarious work conditions , lack of documents and insufficient access to health services.
Bolstering older adults ' sense of mastery in treatment could provide a source of resilience for older adults facing depression.
Bolstering the function of the suACC may represent a potential target for treatment.
Bomback and colleagues studied disease outcome in very elderly patients ( > 80 years old ) with ANCA-associated renal disease.
Bombesin receptor subtype-3 ( BRS-3 ) is an orphan G-protein-coupled receptor ( GPCR ) member of the bombesin receptor family.
Bonded beams were tested in tension until failure.
Bonding agents based on di-phosphates or phosphones showed stable TBS values of less than @number@ MPa under different aging conditions.
Bonding and primer solutions of self-etching systems were also mixed ( SE + P and CP + P ) .
Bonding capital decreased along with a higher age of interviewed women ( r = @number@ p < @number@ ) .
Bonding strength ( mTBS ) and nano-leakage were evaluated immediately after cutting or after @number@ months in water.
Bonding surface of blocks was polished through 1200-grit SiC and air-abraded ( @number@ μm alumina , @number@.28MPa , 20s ) .
Bonding surfaces of @number@ Y-TZP specimens received Vi treatment , and the rest received Si treatment.
Bonds made to ethanol-saturated dentin did not change over time with preservation of hybrid layer integrity.
Bond strength data were analyzed by two-factor ANOVA followed by a post-hoc Tukey's test ( α = 0.05 ) .
Bond strength data were submitted to one-way analysis of variance and Tukey test ( α = 0.05 ) .
Bone adapts to mechanical loads applied on it.
Bone age at pubertal onset SDS was advanced for all patients , but more so for boys and girls with simple-virilizing.
Bone age continues to be a valuable tool in assessing children's health.
Bone and joint diseases are severe problems in the elderly ; therefore , the development of their treatment or prophylaxis is quite important.
Bone and muscle properties were measured by pQCT , and polar distribution of bone mass was obtained in @number@ girl-mother-maternal grandmother trios.
Bone and the skeletal muscle are fat- free tissues which appeared to be independently associated with NAFLD in several cross-sectional studies.
Bone architecture and mass are influenced by the applied tension peak , whereas the bone formation rate is modulated by the stimulus frequency.
Bone atrophy , decreased capacity for tissue repair , and chronic disease are known to influence fracture patterns and operative algorithms in this age group.
Bone biochemical markers were measured in a subset of @number@ subjects.
Bone density can decrease with aging in men but occurs more gradually than in postmenopausal women.
Bone density , length , width and thickness of the coracoid process @number@ mm from the tip were measured four times by two different evaluators.
Bone density was expressed in Hounsfield units ( HU ) .
Bone density was measured at baseline and year @number@ using dual energy x-ray absorptiometry.
Bone destruction occurs in aging and numerous diseases , including osteoporosis and cancer.
Bone disease contributes to relevant morbidity after solid organ transplantation.
Bone formation was demonstrated by histological analysis and immunofluorescence for DMP-1 in tissue sections made from the scaffolds seeded with the cells.
Bone fractures can be devastating with significant morbidity and mortality.
Bone fractures in dialysis patients have been poorly studied in the past.
Bone fragility caused by osteoporosis often results in fractures ; therefore , controlling osteoporosis is crucial to prevent such injuries.
Bone-free lean body mass values were useful predictors of total and cortical area and content ( R ( @number@ ) = 0.338-0.467 ) .
Bone geometry is an important measure of bone strength and is known to be affected by weight-bearing and adult ageing.
Bone glues often suffer from low adhesion to bone under wet conditions.
Bone has a high potential for endogenous self-repair.
Bone has emerged as a novel endocrine organ for its ability to produce hormones and involvement in several regulatory feedback loops.
Bone has evolved to provide structural support to organisms , and therefore its mechanical properties are vital physiologically.
Bone health is an important issue in aging.
Bone is a mineralized conjunctive tissue , with a unique trauma healing capability.
Bone is a tissue that dynamically adapts mass and architecture to the mechanical loads that occur in daily life in a world with gravity.
Bone marrow ( BM ) was the first MSC source characterized.
Bone marrow-derived circulating progenitor cells are involved in tissue repair and regeneration.
Bone marrow-derived human MSCs are permissive for EWS-FLI1 expression with transition to ESFT-like cellular phenotype.
Bone marrow-derived mesenchymal stem cells were cultured and characterized by flow cytometry , cell differentiation assays and G-band karyotyping.
Bone marrow mesenchymal stem cells ( BMSCs ) exhibit an age-dependent reduction in osteogenesis that is accompanied by an increased propensity toward adipocyte differentiation.
Bone marrow stromal cells ( BMSCs ) are considered the ideal candidates for regenerative approaches owing to their beneficial effects in numerous clinical applications.
Bone mass decreases along with aging , especially for women after menopause because of lower estrogen secretion together with low calcium intake.
Bone mass is lost with aging , particularly in menopausal women with lower body mass.
Bone metabolism was measured using bone density , hormones , and biochemical markers.
Bone metastasis is very common in prostate cancer ( PCa ) and causes severe pain.
Bone mineral densitometry was measured using a dual energy X-ray absorptiometry.
Bone mineral density ( BMD ) is affected by lean body mass and body weight to various degrees in the course of aging.
Bone mineral density fell over the 4-5 yr after diagnosis with greater loss in women with lower ovarian activity.
Bone mineral density is known to be a heritable , polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown.
Bone mineral density measurements were measured using dual-energy X-ray absorptiometry.
Bone Mineral density was signicantly associated to lean mass and one leg balance.
Bone mineral measurements of the whole body , hip , lumber spine , and femoral neck were made by dual-energy X-ray absorptiometry.
Bone morphogenetic protein @number@ ( BMP9 ) , a potent osteogenic factor , can up-regulate FSHβ in mouse embryonic fibroblasts ( MEFs ) .
Bone morphogenetic proteins are potent regulators of cell proliferation , differentiation and apoptosis and they have come into the spotlight in arthritis research.
Bone morphogenetic proteins ( BMPs ) have diverse and important roles in the proliferation and differentiation of adult stem cells in our tissues.
Bone morphology and presence of microcracks , which also contribute to bone quality , will not be discussed in this review.
Bone parameters and turnover markers across the three visits were analysed using a linear mixed-effect model with Bonferroni correction.
Bone progressively replaced the original collagen between the granules with a sharply defined transition at the interface.
Bone quality encompasses all the characteristics of bone that , in addition to density , contribute to its resistance to fracture.
Bone quality is a multifactorial entity including bone structural and material compositional properties.
Bone regeneration was assessed through gene expressions , radiographic imaging , histology / histomorphometry , and biomechanical testing.
Bone remodeling is thought to be partially controlled by the hypothalamus , a process which is mediated by the adrenergic nerves and neurotransmitters.
Bone remodeling requires a precise balance between resorption and formation.
Bone resorption was consistently present ( @number@ percent ) at the pyriform aperture and the anterior wall of the maxilla.
Bone resorption was inhibited in the fish oil responders compared to placebo ( P < @number@ ) .
Bones are the foundation of our bodies ; without healthy bones , we can become vulnerable to poor overall health.
Bone shows similar age-dependent changes leading to osteoporosis.
Bone specific alkaline phosphatase was decreased in menstrual cycle levels of estrogen and progesterone treatment.
Bones provide mechanical and protective function , while also serving as housing for marrow and a site for regulation of calcium ion homeostasis.
Bones that had evidence of trauma , malformations or other pathology were excluded.
Bone strength is determined not only by BMD , but also by many other bone quality relating factors such as bone structure etc..
Bone strength was estimated by finite element analysis of quantitative computed tomography data.
Bone structure changes were independent of sex.
Bone substitutes have different indications and are very attractive for orthopedic surgeons.
Bone tissue engineering demands alternatives overcoming the limitations of traditional approaches in the context of a constantly aging global population.
Bone turnover markers ( deoxypiridinoline , bone-specific alkaline phosphatase ) and 25-OHD were determined the day before surgery.
Bone turnover markers were positively correlated with serum sclerostin levels in both sexes.
Bone union was achieved in all cases except one.
Bonferroni correction for multiple comparisons was applied.
Bonferroni correction is very stringent for association studies.
Booster-memory training led to higher verbatim recall.
Bootstrap algorithms have been introduced to provide a non-parametric method to estimate the uncertainty of the measured diffusion parameters.
Bootstrap analyses confirmed these findings.
Bootstrap and ANOVA statistical procedures were employed.
Bootstrapped mediation methods were used ( @number@ bootstrapped samples , @percent@ confidence intervals ) .
Bootstrapping analyses show that low-grade inflammation and endothelial dysfunction mediate the relation between vascular risk factors and cognitive functioning.
Bootstrapping analysis with @number@ resamples confirmed stability for seven neuropsychological tests.
Bootstrapping was used to estimate @percent@ confidence intervals ( CI ) .
Bootstrap procedures further indicated that subjective age has significant total and specific indirect contribution to life satisfaction through subjective health and memory self-efficacy.
Bootstrap procedures indicated that fewer depressive symptoms mediated these associations.
Bootstrap- , sensitivity- and scenario-analyses showed that the costs were robust when varying hospital policy and the duration of visits and tests.
( Boston , New York , and Pittsburgh ) and Denmark.
Bosutinib increased brain and blood IL-10 and CX3CL1 , suggesting a protective role for soluble CX3CL1.
Botanical antioxidants have been shown to be associated with reduced incidence of photocarcinogenesis and photoaging through their photoprotective profile.
Botanical extracts and vitamins may represent novel photoprotective agents.
Botanicals possess numerous bioactivities , and some promote healthy aging.
Both 3DGI and total SA had positive phenotypic correlations with GCA.
Both 40-Hz evoked power and PLF increased monotonically from @number@ through @number@ years , and subsequently decreased toward ages 20-22 years.
Both Achilles tendons were scanned with a real-time SE probe at a frequency of 6-15 MHz.
Both acquired and inherited ( dominant , recessive , and X-linked ) forms exist.
Both active creams were well tolerated with few treatment-related discontinuations.
Both AD and CICI share free radical-mediated oxidative stress in brain , but the source of oxidative stress is not the same.
Both adiponectin and osteocalcin were negatively associated with insulin resistance.
Both admitted and nonadmitted patients reported a reduced quality of life up to @number@ months after the injury.
Both AF and CKD have risk factors for development of each other and eventual mortality.
Both age and HbA1c were associated with episodic memory decline.
Both age and male gender are associated with deeper anterior chambers and larger vitreous cavity.
Both age at move-in and gender were statistically significant predictors of length of stay.
Both Age Groups could significantly reduce overflow when so requested , independent of visual feedback.
Both age groups demonstrated a large P3b component following conflicting , but not prepotent stimuli.
Both age groups of participants trusted younger speakers who had previously told the truth more compared to those who had lied.
Both age groups rated recent memories as significantly less important and as less emotional than more temporally distant events.
Both age groups revealed an equivalent behavioral AVspeech benefit over unisensory trials.
Both age groups showed largely the same associated risk factors.
Both age groups were fairly accurate in predicting forgetting in terms of resolution , indicating that aging does not impair the ability to monitor forgetting.
Both age groups were more accurate when tested with young compared with older faces-but only when judging normality.
Both ageing and autophagy involve several of the signalling components such as insulin / IGF-1 , AMPK , Ras-cAMP-PKA , Sch9 and mTOR.
Both aging and AUD have been associated with compromised white matter microstructure , although the extent of combined AUD and aging effects is unclear.
Both aging and Aβ independently decrease neuronal plasticity.
Both aging and depression are associated with immune responses , and the connectivity among mood-regulating structures may be modulated by inflammatory responses.
Both , aging and osteoporosis are associated problems and have a great importance in relation to their incidence.
Both a high average level of drinking and an episodic heavy pattern of drinking pose prospective risks of later drinking problems among older adults.
Both aims were studied in a sample of community-dwelling elderly individuals as well as in a sample of residential elderly individuals.
Both alerting and orienting conditions modulated the effectiveness of conflict processing by the executive attention network.
Both alpha-rhythms disorganization and increase of beta-activity were usually observed in brain cortex sensomotor areas of @number@ liquidators as compared with @number@ healthy individuals.
Both , altered protein stability and subcellular localization could be partly reversed by blocking proteasomal and lysosomal degradation.
Both amyloid- dependent and amyloid-independent pathological profiles can be identified in the cognitively unimpaired population.
Both androgen-regulated coding genes and noncoding RNAs , including microRNAs ( miRNAs ) were determined as androgen target genes.
Both AP and AIX changed with age ( P < @number@ ) .
Both approaches may be helpful as strategies to prevent dysfunctional aging changes.
Both appropriate and inappropriate medications for older adults are detailed herein , as well as their contraindications and potential drug-drug or drug-disease interactions.
Both are aging-related disorders attributed to Lewy bodies , abnormal protein aggregates or \ "clumps \ " found to cause cumulative neurodegeneration over time.
Both are closely connected to disturbances of proteostasis by protein oxidation and an impairment of the proteasomal system.
Both are significantly greater in @number@ compared to @number@ only in males 19-29 and 30-39 years and in females 30-39 years.
Both at baseline and postrehabilitation , functional status was more strongly related to power and υ ( opt ) than to strength.
Both ATP and O2 ( -• ) / H2O2 are generated by electron transfer reactions.
Both AUD and CUD in previous developmental periods significantly predicted the same substance disorders in subsequent periods.
Both axes were more predictive than any individual markers for baseline chronic diseases and mortality.
Both Aβ-specific and nonspecific alterations were observed.
Both BAC and MBAC contributed to the preservation of resin-dentin bonds , probably because of their inhibitory properties of endogenous dentin proteinases.
Both BACKGROUND : Stereotactic body radiotherapy ( SBRT ) is the standard of care for medically inoperable early-stage non-small-cell lung cancer.
Both basic and clinical evidence have demonstrated the crucial involvement of the STAR protein in the regulation of steroid biosynthesis.
Both , Bay 11-7082 ( @number@ µM ) and parthenolide ( @number@ µM ) triggered eryptosis , effects again most pronounced in aged erythrocytes.
Both behavioral and physiological measures have been used to understand the important factors that contribute to perception-in-noise abilities.
Both biological and psychosocial factors interact with each other to influence sexual functions in men.
Both BPH and PCa are considered to be arisen from aberrant proliferation of prostate stem cells.
Both brain reserve and cognitive reserve appear to mitigate the impact of pathology on cognition.
Both BRCAPRO versions better discriminate BRCA1 than BRCA2 mutations.
Both calcineurin inhibitors increased H2O2 concentrations after stimulation with PHA and led to a shortening of telomeres in PBMCs from young and old individuals.
Both cAMP and cGMP play an important role in a variety of cellular functions including neuroplasticity and neuroprotection.
Both cannot be properly appreciated with conventional MRI.
Both categorization models showed high correlation ( γs = @number@ p < @number@ ) and agreement ( kappa = @number@ p < @number@ ) .
Both causation and selection mechanisms may explain these findings.
Both CD34-positive and tomato lectin-positive blood vessel densities in SAS-R tumor tissues decreased remarkably after the Everolimus and radiation treatment.
Both CD and NCD breeds may therefore serve as models of spontaneous IVDD for human research.
Both CEC and EPC are thought to represent potential biomarkers in several clinical conditions involving endothelial turnover / remodeling.
Both cell-activation markers on the surface of T lymphocytes and cell-bound HIV DNA levels remained stable or declined.
Both c-Fos and SIRT-1 levels were significantly decreased in the ventral hippocampus of twelve-month old 3xTg-AD mice.
Both characteristics appear to be important for major health issues in old age.
Both chemically and enzymatically oxidized apoA-I produced fibrillar amyloids after a few hours of incubation.
Both children and adults had higher sensitivity at @number@.5° / s compared to @number@.6° / s ( paired t-tests , p < 0.05 ) .
Both chronological and stress-induced accelerated aging are associated with cellular senescence and accompanied by marked increases in PAI-1 expression in tissues.
Both circadian rhythms and ME are influenced by genetic factors.
Both circulating testosterone ( T ) and androstenedione ( Adione ) also rise concomitantly but modestly by comparison.
Both cognitive processes have been shown to decline in aging and are theorized to underlie age-related deficits in the cognitive control of memory.
Both cohorts were followed until the end of @number@ or censored.
Both collision-induced dissociation and radical-directed dissociation are needed for detection of these non-mass-shifting post-translational modifications.
Both combination therapy and monotherapy resulted in significant improvements at the follow-up visits compared to baseline ( P < @number@ ) .
Both community-based and clinical-based studies were included.
Both community-based campaigns and E-tools should be integrated within a comprehensive multifaceted stroke promotion strategy to expand their reach.
Both compensatory and neurodegenerative mechanisms contribute to neurophysiological synchronization patterns , which provide a valuable marker for age-related cognitive decline.
Both compounds showed antiproliferative effects correlating with their SIRT2 inhibition potency.
Both conditions are marked by increased adiposity , which can lead to ectopic fat deposition in nonadipocyte tissues including the myocardium.
Both conditions relate to lower aerobic performance and increased body fatness , which have been linked to reduced mitochondrial oxidative capacity.
Both conditions represent independent risk factors for falls.
Both conservative and surgical options are available for treatment.
Both correlation and regression were used to analyze the data.
Both correlation and regression were used to analyze the data.
Both counties were able to achieve modest sodium reductions in prepared meals.
Both countries are ageing and undergoing rapid economic development , urbanisation and social change.
Both countries are aging , but the programs for gerontological training are quite different in the two countries , reflecting underlying cultural values.
Both cross-sectional and longitudinal data analyses provided strong evidence for associations between changes in methylation levels and aging.
Both cross-sectional and longitudinal designs were used with a sample of @number@ women ages 66-79 at baseline.
Both cultured fibroblasts and ADSCs could play an important role in wrinkle reduction despite differences in their mechanisms of action.
Both CV and DV are expressed as Spearman rho correlation coefficients.
Both cystatin C and B2M levels may be affected by inflammation.
Both DASH nutrient score and magnesium intakes were significantly associated with the hazard ratio ( HR ) for total stroke in an inverse relationship.
Both data collection waves include self-administered questionnaires , structured interviews , clinical assessments and observations during home visits effectuated by research staff with project-specific training.
Both datasets include cross-sectional as well as longitudinal information.
Both DC and shrinkage were also influenced by the curing protocol , with positive correlations between DC and shrinkage-strain and DC and shrinkage-strain rate.
Both decreased insulin secretion and insulin resistance are two major factors of impaired glucose tolerance ( IGT ) in the elderly.
Both decreased Na ( v ) 1.1 and elevated surface Na ( v ) 1. @date@ result in a seizure phenotype.
Both DF and PF TΔL relations were more nonlinear in the older adults.
Both DHEA ( r range : @number@ to @number@ ) and testosterone ( r range : @number@ to @number@ ) were inversely associated with age.
Both dietary conditions lasted @number@ weeks with a 2-week washout before crossing over into the alternate condition.
Both differentiation and inflammation involve drastic metabolic changes associated with alterations in mitochondrial dynamics that shift the balance between aerobic glycolysis and oxidative phosphorylation.
Both dimensions increase thereafter.
Both dimensions were then found to have unique associations with well-being.
Both direct and indirect predictors of suicide ideation need to be considered in future BD research and treatment planning.
Both disease and disease-by-age interaction effects were detected in the right fronto-parietal network.
Both diseases are major and growing public health problems because aging of the population contributes to the increasing incidence of those diseases.
Both diseases belong to the progeroid syndromes caused by single gene mutations with premature aging.
Both disorders are clearly related to calcium homeostasis and are highly important in elderly patients due to their poor general prognosis and disabling consequences.
Both disorders increase with age and are associated with outer activity.
Both display size and age affected pointing performance , but the two variables did not interact and aiming duration moderated both effects.
Both DNA binding and transactivation activities of p53 are required for Arf repression.
Both DOE and VASE confirmed that fibrinogen forms a thicker and more packed surface adlayer compared to a more porous and weakly adsorbed albumin adlayer.
Both do not provide an adequate time window for effective stroke therapy in clinical practice.
Both doses attenuated the LPS effects on PGE₂ , and TXB₂.
Both doses of CTCMC significantly lowered urinary excretion of both oxidation indicators.
Both doxazosin and terazosin were significantly more likely than finasteride to improve peak urine flow and nocturia , versus finasteride.
Both dual biomarker approaches offer significant risk reclassification improvement over NT-proBNP.
Both duration of walking and summer sun exposure predicted a CDT score > 0 in UVA.
Both ears of all participants were tested.
Both ED and systolic hypertension may be associated with PE.
Both edentulism and number of missing teeth declined over time , but their patterns varied.
Both education and subjective financial satisfaction were used as SES measures in the present study.
Both effects involve putative Klotho sialidase activity.
Both effects were less pronounced in older adults.
Both effects were not seen in young adults.
Both eicosapentaenoic acid ( EPA ) and DHA have an effect on membrane receptor function and even neurotransmitter generation and metabolism.
Both elastomers showed Shore A hardness values within clinical acceptable limits after aging.
Both elderly groups showed greater activation in response to acoustical stimuli in the temporal lobes in comparison with young subjects.
Both endogenous processes and exogenous physical and chemical sources generate deoxyribonucleic acid ( DNA ) damage in the nucleus and organelles of living cells.
Both environmental and genetic factors contribute to the development of these diseases.
Both equimolar concentration and saturated solubility in @percent@ ethanol were used as the applied dose.
Both estrogen role in women and androgen role in men are well established recently.
Both estrogens influenced vaginal smear profiles , uterine weights , and serum luteinizing hormone levels , analogous to classic estrogens.
Both events , either individually or in cooperation , result in the development and progression of cancer.
Both exact calculation and permutation and gamma approximations have been proposed to determine molecule-level significance.
Both exercise and recreational activities are promising strategies.
Both experiments provided support for both predictions.
Both experiments showed age-invariance in memory-as-discrimination : cues increasing encoding-retrieval match did not benefit memory unless they also improved discrimination between the target and competitors.
Both experiments showed that an impairment in visual acuity leads to increased interference in the reading-with-distraction task.
Both experiments were run in arithmetic problem solving.
Both expressed the G-protein-coupled estrogen receptor ( GPER1 ) .
Both [ F-18 ] FDDNP microPET imaging and neuropathological analyses revealed decreased Aβ burden after intracranial anti-Aβ antibody administration.
Both factors are easily determined by history.
Both factors are independent predictors of death among white and AA adults.
Both factors are independent risk factors for Alzheimer's disease that may also cooperatively regulate pathologic interactions between T2D and dementia.
Both factors had medium-to-large positive correlations with hopelessness , depression , suicide ideation , and low meaning in life , providing evidence for convergent validity.
Both factors were positively related with meaning in life and life satisfaction and negatively related with depression ( p < @number@ ) .
Both Factor XIIIa + dermal dendrocytes and the microvasculature size decreased with scalp ageing.
Both falls and fear of falls may result in restrictions of physical activity , which in turn have health consequences.
Both fillers were well tolerated , and adverse reactions were mild.
Both fillers were well tolerated , with similar worst score distribution and mean score for erythema , edema / swelling , bruising , and pruritus.
Both findings could be adequately described by linear functions of age.
Both fluoride-containing adhesives seemed to demonstrate reliable bonding performance after @number@ year of accelerated aging in water.
Both forms have unique features , which may help to differentiate background causes.
Both forms of external interference have been shown to detrimentally impact the ability to maintain information in working memory ( WM ) .
Both FOXO and 4E-BP delay muscle functional decay and extend life span.
Both frailty and cognitive decline share common potential mechanisms.
Both free testosterone and DHEA decreased with age.
Both frontal PVWMH and DWMH were significantly more extensive in the AD group compared to the NA group or the NA and borderline groups combined.
Both FTD and schizophrenia lead to cognitive disorders and particularly to executive impairments.
Both full-term and preterm neonates are born with low levels of most procoagulant proteins including all the contact activation factors and vitamin K-dependent factors.
Both gait and cognitive impairments are risk factors for falls in older adults.
Both genders were analyzed separately.
Both genetic and post-genetic mechanisms are susceptible to be influenced by medical , pharmacological and dietary interventions.
Both genetic background and hemodynamic factors have been associated with progression of age-related morphological changes.
Both genotype groups exhibited equal language performance at approximately @number@ years of age.
Both GM muscle volume ( P = @number@ ) and PCSA ( P = @number@ ) exhibited significant age × BMI interactions.
Both groups also improved in the sit-to-stand test ( P < 0.05 ; 1-SET : @percent@ ; 3-SET : @percent@ ) .
Both groups also showed strong functional coupling among SLN regions during incorrect trials and in intrinsic patterns of functional connectivity.
Both groups cited their environment and circumstances as influencing their drinking.
Both groups completed a similar questionnaire created to assess knowledge of ED.
Both groups could benefit from falls awareness and prevention programs.
Both groups did not differ in mobility or cognition data.
Both groups displayed limited evidence for a relationship between hippocampal volume and fMRI activation.
Both groups experienced improvements.
Both groups experienced increases in MROM and peak passive torque and decreases in the passive resistance to stretch.
Both groups had an interview in which they described the place music had in their lives.
Both groups had low scores for depression and high scores for social dysfunction , anxiety , insomnia and somatisation.
Both groups had more time to spare when they were required to slow down than when they were required to speed up.
Both groups had the sedentary energy expenditure and the lying duration at the same level.
Both groups @number@ and @number@ increased MPA ≥30 min / day.
Both groups of dogs expressed clear-cut patterns of attachment to their owners.
Both groups of observers performed similarly on central and medium-contrast pictures.
Both groups participated in hour-long exercise classes 3× / week over the 8-week study period.
Both groups participated in @number@ weeks of exercise , @number@ times / week for @number@ h.
Both groups participated in social and creative and assisted-mobility activities.
Both groups perceived similarly high levels of familial social support.
Both groups performed a clock drawing task using a computerized system.
Both groups presented anxiety / depression symptoms.
Both groups received fully balanced speed or accuracy instructions and an individually adapted deadline in both tasks.
Both groups received @number@ telephone contacts from a master's-level therapist over @number@ months.
Both groups received similar protein supplementations.
Both groups reported a reduction of neuropsychiatric symptoms of their AD relative after intervention.
Both groups reported decreased negative affect and trait anxiety , and increased optimism across the three assessments.
Both groups showed an attentional bias to fall-threat words but those who were fearful of falling also showed an incongruency effect for fall-threat words.
Both groups showed a significant improvement in MBI and MMSE scores after @number@ months , and there was no significant between-group difference.
Both groups showed equivalent source accuracy benefits for objects encoded self-referentially.
Both groups showed good control of diabetes during the study.
Both groups showed greater memory for attended than unattended contextual features.
Both groups showed increased activation during dual-task ( p < 0.002 ) and during obstacle negotiation ( p < 0.003 ) .
Both groups showed reaction time reduction over the semantic procedural task , but the PD group produced longer reaction times than the control subjects.
Both groups showed reduced connectivity in the parietal regions of the right working memory network compared with controls.
Both groups showed significant improvements in six-minute walk distance ( 2TG : P = 0.003 , 3TG : P = 0.001 ) .
Both groups showed similar physical functional capacity performances with regard to walking speed , muscle strength , and lower limb physical functioning.
Both groups underwent CERAD-nb investigation as a part of a wider examination procedure.
Both groups underwent EC-IC bypass surgery after careful preoperative work-up.
Both groups walked slower in the mall simulation.
Both groups were divided into three subgroups based on their age ( young , middle-aged , or elderly ) .
Both groups were exposed to a prolonged bout of running ( @number@ km ) .
Both groups were exposed to extreme physical activity , as well.
Both groups were followed up for @number@ years after falls.
Both groups were inquired to answer the Androgen Deficiency for aging male ( ADAM ) questionnaire.
Both groups were sensitive for non-contingency in both dyadic and triadic interactions.
Both groups were serving in states familiar to them and within communities where they felt accepted.
Both groups were similar regarding age , sex , psychotic features , mean baseline MADRS , and median baseline MMSE.
Both groups were stratified into upper ( L1-L2 ) and lower ( L3- @date@ levels , males and females younger or older than @number@ years.
Both groups were tested in both information conditions at baseline and post-test.
Both groups were tested using a microtensile method.
Both groups were treated for twelve sessions , @number@ minutes per session , for @number@ weeks ( two sessions per week ) .
Both groups will receive the traditional primary care lifestyle counseling prior to randomization.
Both groups wore an ActiGraph accelerometer for one week.
Both had features classically associated with the atherosclerosis of aging , as well as arteriolosclerosis of small vessels.
Both had high overall compatibility , high relative advantage , good observability and high inherent trialability all factors known to strengthen implementation.
Both HA IDF plus and HA IDF were considerably tolerated and most adverse reactions were mild and transient.
Both have negative impacts on cognition in the elderly.
Both HDL size and volume were influenced by gender and varied according to age.
Both healthy aging and the pathologic incidence of disorders associated with aging involve an array of debilities.
Both hepatotoxicity and acute neurologic deficit have been reported previously as extremely rare adverse events after metronidazole administration.
Both hereditary and sporadic breast cancers may develop through dysregulation of self-renewal pathways of normal mammary stem cells.
Both HF with reduced ejection fraction and HF with preserved ejection fraction are considered.
Both HGPS-MSC and -VSMC viability was compromised by stress and hypoxia in vitro and in vivo ( MSC ) .
Both high and low blood pressure levels have been reported to be associated with impairment in cognitive function in older subjects.
Both high BMI and diabetes are vascular risk factors that might play a role in the development of Alzheimer's disease ( AD ) and dementia.
Both high novelty seeking and high persistence predicted overall personality change.
Both hip and vertebral fractures are associated with increased morbidity and mortality in men.
Both HIV and antiretroviral therapy could induce vascular aging with unclear mechanisms.
Both HIV-Tat protein and antiretroviral agents could induce EC senescence , which was inhibited by miR-34a inhibition.
Both humoral and cellular immune responses are impaired in aged individuals , leading to decreased vaccine responses.
Both hypometabolic and hypermetabolic regions were observed in ε4 carriers compared with noncarriers when age , education , and sex were controlled.
Both hypotheses were supported.
Both HZ and post-herpetic neuralgia may impact the quality of life , functional status , mental health , and social interaction in older adults.
Both IFNγ and IL-13 were negatively correlated with age in women but not in men.
Both IGF-1 and TL diminish with age and are positively and strongly correlated with each other.
Both IMCL and EMCL were higher in overweight / obese men.
Both immunoprecipitation and pull-down assays demonstrated that SAP97 failed to correctly couple to ADAM10 and GluR1 , but not to NR2A.
Both impairments contribute to the development of insulin resistance , obesity and chronic age-related diseases.
Both increases and decreases in resting state functional connectivity have been previously observed within the motor network during aging.
Both independent mechanisms reduce SLC16A11 function and suggest SLC16A11 is the causal gene at this locus.
Both individual CR measures and a composite CR score were used.
Both induction and inhibition of autophagy have been proven to be beneficial in the treatment of cancer.
Both ineffective esophageal bolus transport and increased EGJ resistance contribute to impaired bolus flow.
Both inflammation and angiogenesis are interconnected with each other in the sense that many pro-inflammatory proteins possess proangiogenic properties and vice versa.
Both inflammatory and structural abnormalities were found in @number@ ( @percent@ ) subjects.
Both injections were well tolerated , and the adverse reactions were mild and transient in most cases.
Both in men and women , total performance was lower for participants with OA , with greater differences in men.
Both innate and adaptive immunity are compromised during aging , a condition where an inflammatory status contributes to promote immune suppression and tumour growth.
Both integrative and semantic pairs showed significantly smaller age differences in associative memory compared to unrelated pairs.
Both interactions were found mainly or only in Northern Europeans.
Both interhemispheric disconnectivity ( callosal atrophy ) and intrahemispheric disconnectivity ( subcortical white matter lesions ) appear to be important factors contributing to these findings.
Both intervention groups significantly increased GH pulse frequency ( TT-group , P = 0.04 ; AI-group , P = 0.05 ) compared to placebo.
Both interventions targeted a team of the unit manager , the head nurse , and 5-10 of the care staff.
Both intrinsic and extrinsic factors contribute to health.
Both in vitro and in vitro findings indicate a deleterious effect of lipid and glucose abnormalities on cartilage homeostasis.
Both irritable bowel syndrome and diverticular formation and subsequent diverticulitis have worsened in recent years owing to excessive dietary fiber intake.
Both ISH models induced consistent behavior deficits.
Both isoforms are present at low levels in HGPS patient and wild type cells in multiple cell types.
Both IV analyses showed associations between NP care and lower potentially preventable hospitalizations , but only @number@ result was statistically significant.
Both kinetics and magnitude of antiviral gene expression were diminished as a result of older age.
Both knockdown of CREB and treatment with a protein kinase A inhibitor H-89 blocked PTH stimulation of osteoblast differentiation in hMSCs from young subjects.
Both LADH levels and activities were found to be significantly reduced in AD brain compared to age-matched control.
Both lasers had an easily controllable thin laser beam , which enabled the physician to control tissue damage and minimize discomfort and pain.
Both laser types could be applied either singly in turns , or in combination for maximal efficacy in future.
Both lasted @number@ weeks , with twice-weekly , 1-hour , physical therapist-supervised sessions.
Both left-lateral ( P = @number@ ) and right-lateral ( P = @number@ ) functional reach scores improved.
Both ligands presented similar orientations within the PPARγ binding site.
Both lines of research suggest that there may be epistatic relationships between genes involved in amyloid and tau pathophysiology.
Both liver volume and blood flow decrease significantly with age.
Both LKB1 and AMPK activity were decreased in mouse knee OA and aged knee cartilage , and in bovine chondrocytes after biomechanical injury.
Both loneliness and depression should be actively recognized earlier and appropriately treated because they are significant sources of cognitive impairment in the elderly.
Both , long-term quiescent and senescent fibroblasts almost completely fail to undergo apoptosis.
Both lost and new ties were weaker than ties that persisted throughout the study period.
Both lower baseline CR fitness and declining CR fitness over @number@ years were associated with regional brain atrophy.
Both low growth and low SES were associated with increased rate of cognitive decline.
Both LQT1 and LQT2 male patients showed QTc interval shortening after the onset of puberty.
Both maintenance prescriptions preserved phase @number@ muscle hypertrophy in the young but not the old.
Both manipulations improved performance for elderly adults with age-appropriate hearing on both tasks.
Both markers have very distinct denaturation rates which would not allow them to be used in a single marker setup while still providing satisfactory results.
Both maximum and minimum LAVs exponentially increased with age and linearly increased with increasing of body surface area ( BSA ) .
Both measurement and conceptual models of our hypotheses were tested using Mplus @number@
Both measures are critical variables in the study of developmental neuropathology.
Both measures discriminated between subgroups of respondents.
Both measures may be sensitive biomarkers for AD.
Both measures of functional status improved and were sustained after three months of TC.
Both measures of proprioception error correlated with age ( P≤.001 ) .
Both measures of spinophilin were lower in mAD and sAD compared with NCI.
Both measures remained depressed during the 30-min recovery period.
Both measures were responsive to falls that occurred during the first @number@ months of the study ( p < @number@ ) .
Both mechanisms lead to anemia and reduce physical fitness which , in a vicious cycle , can support the development of pathological obesity.
Both median and mean AMH values decreased steadily in a manner highly correlated with advancing age.
Both Medicare and private insurers offer coverage of LDCT screening to beneficiaries who are at high risk of developing lung cancer.
Both men and women find nonsexual physical contact appealing but sexual physical contact is more appealing to men than women.
Both men and women showed a statistically significant improvement in physical performance tests.
Both men and women with higher social support and income had significantly better mental health.
Both mental health and physical health measures indicate the health restoration and independence effectiveness of the AIP model for long-term care.
Both metabolite ratios and absolute metabolite concentrations were evaluated.
Both methods captured the age effect on LTL and the longer LTL in women than in men.
Both methods have wide applications for low signal-to-noise ratio data.
Both methods provide complementary perspectives on bus usability , which could not be gained from either method alone.
Both methods showed significant correlation for weekday for the overall group.
Both midurethral slings and pubovaginal slings have reported high rates of short and long term success and patient satisfaction.
Both models have received empirical validation.
Both models produced similar absolute risks.
Both modules address practical approaches to addressing palliative care in patients and their families.
Both mood and sleep disorders have been associated with the menopausal transition , but observed effects appear modest.
Both mouse models exhibit Aβ deposition in the brain , but with different onset and progression trajectories.
Both MRI-derived measures were normalized by the intracranial volume.
Both MTA and PA scales showed good inter- and intrarater reliabilities ( kappa > @number@ ) .
Both multiplex systems could successfully identify semen with spermatozoa and could differentiate menstrual blood and vaginal fluids from blood and saliva.
Both multi-view data models exhibited ensemble classification accuracies significantly above chance.
Both muscles displayed greater changes at L5-S1 than L3-L4.
Both mutations are predicted to be pathogenic.
Both mutations reside in trans-membrane C-terminal domain critical for HBsAg-secretion.
Both myeloid and mesenchymal fibroblasts contribute to fibrosis in the aging heart via collagen synthesis.
Both NADPH and apocynin significantly reduced infarct volume , improved post-stroke survival , and recovery of neurological functions in mouse model of stroke.
Both naked mole rats and humans strongly decreased the pressure of natural selection , although in two different manners.
Both neoplastic and nonneoplastic lesions were examined.
Both neuritic plaques and neurofibrillary tangles independently predicted Clinical Dementia Rating-Sum of Boxes.
Both neurons and glia expressed Apo D , particularly neurons with larger somata and glia in the periphery of these brainstem centers.
Both nonablative RF and ultrasound create a heat-induced tissue response that leads to collagen remodeling and other ultrastructural changes.
Both normal aging and dementia are associated with altered circadian regulation of physiology and behavior.
Both OA groups also had the femur less posterior relative to the tibia and smaller extension moment than the younger group.
Both obstructive sleep apnea ( OSA ) and type @number@ diabetes mellitus are commonly seen in older adults.
Both of them are involved in the development of osteoporosis that increases risk of fractures.
Both of them presented with auditory hallucinations and had comorbid alcohol abuse.
Both of them were found in all frequency bands.
Both of these approaches are based on similarity measurements between data vectors.
Both of these are best determined by rate measures rather than measures at a single time point.
Both of these are high-prevalence diseases in the elderly , and yet studies have indicated that digoxin may not be used appropriately in this population.
Both of these goals can be reflected in a return to employment.
Both of these groups differed from older adults tested in the afternoon during the tasks-but not rest.
Both of these states play a significant role in pathobiology of COPD and may account for development of major comorbidities of this disease.
Both of these strategies need to be considered in the context of addressing racial , ethnic , socioeconomic , and health status disparities.
Both older adult groups were more susceptible to the illusion at longer SOAs than younger adults.
Both original research and review articles are included in this Forum on Redox Proteomics.
Both osteonal size and pores area were negatively associated with age.
Both overall and specific factors of cognitive failures were determined.
Both over-expression of RASGRP1 and shRNA-mediated knockdown of ILK partially restore cellular senescence in Pparβ / δ-null cells.
Both parameters decrease during life , markedly during the first and third phases.
Both parents were heterozygous for this sequence variation.
Both Parkinson's disease ( PD ) and stroke are debilitating conditions that result in neuronal death and loss of neurological functions.
Both patient and proxy ratings were moderately correlated with the objective measures.
Both patient groups did not differ significantly in gender , vascular pathology , previous history of diseases / comorbidity or clinical symptoms.
Both patient groups were impaired on tasks assessing verbal and visual recognition memory.
Both patients and an increasing number of doctors are willing to contribute to this system of integrated care.
Both patients and caregivers assigned higher preference ratings for representational than for abstract works and preference consistency was comparable in representational and abstract works.
Both patients and caregivers rated informational needs as most important , followed by emotional and , finally , by instrumental needs.
Both patients and controls activated a canonical MTL encoding network.
Both patients ' gender and colours of cups affected choices made by adults and children.
Both patients received 2×10 ( @number@ ) cells per kilogram , and each subsequently improved with resolution of respiratory , hemodynamic , and multiorgan failure.
Both patients with cancer complicated with cardiovascular disease and patients with cancer developing cardiovascular disorder during cancer therapyare increasing recently.
Both patients with gastrostomies and nasogastric feeding tubes were included in the alternative feeding group.
Both patterns also involved similar frontoparietal brain regions that were increasing in activity with memory load , and mediofrontal and temporal regions that were decreasing.
Both phenomena are accelerated and exacerbated in patients with the most common age-related diseases ( ARDs ) , including cancer.
Both physical disability and cognitive impairment were strong predictors of the amount of received care for both elderly and intellectually disabled individuals.
Both physical health and mental health were negatively associated with neuroticism and positively associated with extraversion and conscientiousness.
Both PiB ( @percent@ ) and FDG ( @percent@ ) showed high agreement with autopsy diagnosis.
Both pipelines weakly correlated with MMSE decay , showing no significant differences.
Both pipelines were weakly or mildly correlated with the Mini Mental State Examination score ( MMSE ) and the hippocampal volumetry.
Both placebo and sibutramine gave a similar improvement of HOMA-IR , leptin , TNF-α , ADN , and Hs-CRP.
Both poor appetite and poor cognition predicted death.
Both posterior cingulate cortex seed and interconnected peak cluster volumes predicted cognitive test scores , especially in the T carriers.
Both PPV and NPV have improved since @number@
Both practice and knowledge are an essential foundation to providing good end-of-life care to nursing home residents.
Both preparations were well tolerated.
Both primary neural representations of movement and potential compensatory cognitive mechanisms appear to be disrupted in older age.
Both PRKCB and MAPK1 were increased in the late AD stages.
Both products improved considerably wrinkles , mottled pigmentation , pores , and global photodamage.
Both products were found to be equally safe and well tolerated.
Both products were well tolerated , without serious adverse events.
Both programs were reported to have beneficial effects for seniors and to benefit children in the academic , social , and emotional domains.
Both protein and mRNA levels of IF5 / BTG4 were reduced by aging when comparing 4-week-old mice with 48-week-old mice.
Both protein synthesis and degradation are influenced by distinct genetic pathways that control aging in divergent eukaryotic species.
Both provider and patient experiences with the programme were also assessed using a patient telephone satisfaction survey and provider focus group.
Both PS externalization and shedding are modulated by the oxidative state of the cells.
Both psychological and physical symptoms affect women's activities of daily life.
Both PT and ST paused briefly at the midpoint of the movement and completed the eccentric phase of the movement in 2-3 s.
Both quadriceps and hamstrings were contracted voluntarily or electrically at the same time for @number@ min twice a week.
Both qualitative and quantitative evaluation results demonstrate the validity of the proposed method.
Both qualitative ( spindle presence ) and quantitative ( retardance ) data were correlated to the key assisted reproduction technology outcome parameters.
Both quantitative RT-PCR and immunohistochemistry were carried out to verify the microarray results.
Both raw and T-scores > 2.0 SD from the mean were infrequent.
Both recognition and identification performance were negatively affected by age and more pronounced among the cognitively impaired.
Both recovery time of post-exercise muscle oxygenation and muscle strength decline with aging.
Both RECQL4 and p53 bind to the exonuclease and polymerase domains of PolγA.
Both reduced within-network connectivity and increased out-of-network connectivity were correlated with poor cognitive performance , providing potential biomarkers for cognitive aging.
Both reflexes were recorded in response to AC clicks , AC and BC @number@ Hz tone bursts , forehead taps and lateral mastoid accelerations.
Both regimens maintained intracellular ATP through the chronological aging process and showed enhanced mitochondrial capacity.
Both REM-AHI and NREM-AHI were reduced significantly more in ILI versus DSE , but these differences were attenuated slightly after adjustment for weight changes.
Both replicative ( RS ) and stress-induced premature senescence ( SIPS ) accompany cardiovascular diseases.
Both represent potentially reversible memory disturbances and have a treatment based on antiepileptic drugs.
Both researchers and commercial companies expend significant time and resources to reduce the error rate.
Both research instruments included areas of disruption to the organization , existing policies , and feasibility as to developing appropriate policies to support working carers.
Both results are significant at the @percent@ level.
Both rhinitis and asthma prevalences were higher in persons < 60 years.
Both right- and interval-censored data are considered.
Both right and left lung areas were measured in the heart 4-chamber view using lung area tracing and axis diameter methods.
Both rs34517613 and rs3849942 showed no evidence of association in Chinese.
Both RT and HIIT enhanced proteins involved in translational machinery irrespective of age.
Both rural and urban area resident children's ( boys , girls ) SAP / DAP was evaluated.
Both S1 and S3 comprised a set of ten repetitions of ten exercises , with an interval of @number@ seconds between exercises.
Both S50% and S80% were composed of a set of ten repetitions of ten exercises , with an interval of @number@ s between exercises.
Both samples were from the same districts of Paris and were assessed with the same neuropsychological test battery.
Both samples were screened for dementia.
Both saturation and the red component of colour were slightly higher in CS wines.
Both SBP and DBP showed significant positive correlations with age , weight , BMI and waist circumference.
Both scales predicted equally well PWB and forgiveness in predicted directions.
Both Scn5a disruption and aging were associated with decreased heart rate variability , reduced sinoatrial node automaticity , and slowed sinoatrial conduction.
Both SCUs and SH units seem to have stable staffing ratios and the number of beds in each unit is also stable.
Both self-centered ( egocentric ) and world-centered ( allocentric ) spatial navigation was assessed.
Both self-reported ( p < .0001 ) and performance assessment of balance ( p = .05 ) at baseline were related to falls incidence.
Both self-tests had good convergent validity as demonstrated by moderate to strong rank correlations with neuropsychological tests.
Both sexes displayed a near-plateau in the %Δ [ HHb ] which occurred at an exercise intensity near the respiratory compensation point.
Both SF-12 and AMS changes were greater than reported minimum clinically important differences.
Both simulation and phantom studies provide evidence that the proposed method has the potential to satisfy the requirement of fast image reconstruction in practical CT.
Both SNPs affect CpG dinucleotides , whereby each haplotype contains a potential methylation site at one of the two SNP positions.
Both sociobehavioural and HIV-related clinical factors were independently associated with an increasing burden of geriatric condition in HIV.
Both sortilin and SorCS2 act as cell surface receptors to mediate acute responses to proneurotrophins.
Both specific classes of drugs and the total number of drugs taken are associated with falls.
Both sporadic and familial NIID cases presented with a decline in Mini-Mental State Examination and Frontal Assessment Battery scores.
Both standing pattern B and clear visual input decreased maximal moved distance in younger adults and older patients.
Both STS reactivation and hippocampal structure predicted subsequent recognition performance.
Both studies enroll subjects without diagnosed dementia , perform annual evaluations , and obtain autopsies proximate to death.
Both studies have collected DNA samples and are working toward genotyping that would allow broadly based association studies.
Both subgroups underwent a cervical spine MRI in 2004-2005 and @number@ years later in @number@
Both SUI and POP are prevalent medical conditions , affecting 15-17% and 3-6% of women respectively.
Both surveys had multiple-choice options and opportunities for open-ended responses , yielding quantitative and qualitative information.
Both sustained and nonsustained VT were included.
Both syndromes are very rare autosomal recessive diseases caused by a gene defect leading to deficient DNA repair.
Both tasks elicited widespread patterns of activation and deactivation associated with large task-level manipulations of attention.
Both tasks revealed that a large proportion of infants are still developing a hand-use preference during this age period.
Both tau and phosphorylated tau aggregate in a similar manner when they are incubated with 14-3-3ζ.
Both techniques are indicated for the treatment of skin laxity.
Both technologies identified inactivation of the PI3K / Akt / mTOR pathway accompanying premature senescence.
Both telomere length and telomere G-tail length are altered in human diseases such as cancer and age-related diseases.
Both testosterone replacement and EL supplementation to orchidectomised rats were able to maintain the bone calcium level , with the former showing better effects.
Both tests , however , demonstrated inconsistent discriminant validity against a variety of standard non-ECF tests ( rs @number@ to @number@ ) .
Both Th1 and Th2 cells were largely maintained in the circulation of aged humans , whereas Th17 cells were decreased.
Both the age and the recruitment time of the village doctors were demonstrated to have a bimodal distribution.
Both the ageing of the Chinese population and elderly mobility impact on the Chinese social infrastructure , triggering challenges to maintain elderly wellbeing.
Both the aging process and heart failure ( HF ) syndrome are characterized by a dramatic reduction of aerobic capacity.
Both the AML and PML samples exhibited a nonlinear and anisotropic behavior with the circumferential direction being stiffer than the radial direction.
Both the causality of and explanations for gender-specific differences in these relationships remain subject to further studies.
Both the costs associated with treating these diseases and the potential to increase morbidity and mortality are high for this patient population.
Both the depth and the length of the nasolabial folds were decreased conspicuously.
Both the direct and the indirect effects of oxidation and their potential importance in neurodegeneration are considered.
Both the dopaminergic and glutamatergic systems modulate episodic memory consolidation.
Both the electrocardiogram and Holter confirmed the existence of sinus bradycardia and sinus arrest.
Both the English and Yoruba versions of the study instruments were used depending on the level of education of the participants.
Both the examiner and hand placement orders were counterbalanced to account for order and fatigue effects.
Both the extracts and chemical components isolated from the plant showed a wide range of biological activities.
Both , the FACE-Q and the MERZ Aesthetic Scales showed significant improvements at 12-month post-surgery ( p < @number@ ) .
Both the fibre angle and the moment generation capability of the muscles decreased with ageing ( P < 0.01 ) .
Both the force plate and the head-mounted display balance-assessment system were able to detect differences between conditions meant to mask visual and proprioceptive information.
Both the HNSP rate and projected RVUs increase approximate @percent@.
Both the impact of pain and its severity should be established by questioning about the presence of pain and using pain assessment instruments.
Both the innate and the adaptive branches of the immune system are affected , including neutrophils , macrophages , dendritic cells and lymphocytes.
Both the intervention effects in the target group ( outcome ) and the results of the implementation process ( output ) will be evaluated.
Both the IPS and RBS were negatively related to the rGMD in the right posterior insula ( PI ) .
Both the levels and pattern of Cryab expression in the SN were validated.
Both the lowest quintile for each parameter ( ethnic-specific cutoff ) and FNIH-recommended values were used as cutoffs.
Both the number and total length of MDx were higher close to the inner ear space as compared with the capsular periphery.
Both the protein and lipid components are required for PIB binding.
Both the questionnaire and the discrete choice experiment were performed with the same sample.
Both therapeutic agents have manageable side effect profiles.
Both the route of administration and structure of these estrogens play a role in the overall pharmacology of CEE.
Both these approaches have limitations that are expensive , invasive or time consuming and thus preclude them from screening at-risk population.
Both these substrates affect neural communication by influencing presynaptic neurotransmitter release and postsynaptic intracellular pathways after neurotransmitter binding to its receptor.
Both the stem cell tourist and travel medicine practitioner should be educated on the potential risks associated with stem cell clinical services advertised online.
Both the test formulation and its vehicle were tolerated well.
Both the ubiquitin-conjugating enzymes and the proteasome can be inactivated by sustained oxidative stress , especially the 26S proteasome.
Both thresholds were also obtained while varying the position of the flanker ( placed inside or outside of target , relative to fixation ) .
Both TLR2 and MyD88 are required for CEP-induced stimulation of Rac1 and endothelial migration.
Both TOF and CE-MRA images were used to evaluate morphologic features that impact the risk of rupture and the selection of a treatment.
Both torque and velocity were significantly associated with muscle power in OH.
Both trabecular and periosteal bone formation decline with age in both sexes , which contributes to bone fragility and increased risk of fractures.
Both treatment of obesity and prevention of obesity-related diseases are frequently not successful.
Both treatment protocols produced similar effects in relation to the improvement of photoaging-induced pigmentation.
Both treatment regimens yielded signi cant improvements in wrinkle / elastosis scores , which were maintained throughout the @number@ months of follow up.
Both treatments demonstrated favorable tolerability.
Both treatments resulted in suppression of activated ( phosphorylated ) forms of focal adhesion kinase ( FAK ) and Erk.
Both type @number@ and type @number@ diabetes adversely affect the microvasculature in multiple organs.
Both ubiquitin proteasomal and autophagic pathways contribute to the degradation of mutant Htt.
Both undifferentiated cell types showed similar fibroblast-like morphology and mesenchymal marker expression.
Both univariate and multivariate twin models were fitted to the three phenotypes with full and nested models and compared to select the best fitting models.
Both , up-regulation of telomere-regulating proteins and prevention of oxidative stress-induced aortic apoptosis , were absent in telomerase reverse transcriptase ( TERT ) -deficient mice.
Both vaginal laxity and urinary incontinence significantly affect patients ' quality of life ( QoL ) .
Both vary between individuals and , at least partially , are under genetic control.
Both versions of the SAI had acceptable psychometric properties.
Both versions significantly predicted the risk of falling and performed slightly better in ≥65-year old persons than in younger ( 53-64-year old ) persons.
Both vit-D deficiency and BMI were associated with impaired global LV longitudinal strain , independent of T2DM disease characteristics.
Both VO2peak and TT performance were back to baseline @number@ days after blood donation.
Both were assigned retrospectively.
Both were high among women aged @number@ years and above , while younger patients ( 51-70 years of age ) had slightly lower values.
Both were quantified using minutes of moderate-intensity physical activity and categorized as inactive , insufficiently active , or sufficiently active.
Both were up-regulated after oxidant insult , but expression levels decreased in aging cells.
Both wild-type and APP / PS1 mice , a transgenic AD mouse model , received control AIN-93G diet or AIN-93G supplemented with resveratrol.
Both wild-type and BSG-null cells were extremely sensitive to the mitochondria inhibitor metformin / phenformin in normoxia.
Both working memory ( WM ) and the congruency of the immediately preceding trial have also been shown to moderate the magnitude of Stroop interference.
Both young and elderly participants had good perception of weight-bearing distribution , with mean absolute errors of @percent@.
Both young and older adults also spoke more slowly when rewarded for tracking and more rapidly when rewarded for talking.
Both young and older adults responded to monetary incentives to vary their performance when simultaneously talking and tracking a pursuit rotor.
Both , young and old late generation Terc ( - / - ) , showed increased pro-inflammatory cytokine levels.
Both younger and older adults produced reduced word-frequency effects and lexicality effects in the regularization task compared to the normal pronunciation task.
Both Y-TZP ceramics suffered t→m phase transformation after 60-day intra-oral aging ( Plus = 4.7% / Frame = 7.7% ) .
Both zirconia-based ceramics have been clinically available as an alternative to the metal framework for fixed dental prostheses ( FDPs ) .
Both α-synuclein ( α-syn ) missense and multiplication mutations have been linked to PD.
Both ε4 status and DTI correlated with change in immediate recall.
Botox treatment was a quite effective and safe strategy to improve the appearance and contour of the lower face in Asian patients.
Bottle aging affected the sensory profiles of smoke-affected wines in different ways.
Bottles were used on the previous day by @number@ ( @percent@ ) of the @number@ mothers not offering exclusive breastfeeding.
Botulinum neurotoxin-A ( BoNT-A ) has become widely used in aesthetic applications over the past @number@ years with several formulations now available.
Botulinum neurotoxin type A ( BTX-A ) preparations are well established for cosmetic use.
Botulinum toxin A ( BoNTA ) has been an approved and effective treatment of glabellar lines.
Botulinum toxin ( BoNT ) has been approved for aesthetic use since @number@
Botulinum toxin has also multiple other indications in different medical fields.
Botulinum toxin injections have become the most frequent noninvasive cosmetic procedure carried out worldwide.
Botulinum toxins are among the most widely studied and versatile drugs in the medicinal market.
Boundary maps generated based on traveling time at various times of day for combinations of hubs.
Bovine collagen is the first approved material for filler injection , and several studies have shown its efficacy.
Bowman's layer thickness was determined from IVCM images of anterior and posterior BL boundaries.
Box-Cox analysis is a technique to increase the log-likelihood of linear relationships between variables by means of monotonic non-linear transformations.
Boys experience their most rapid growth in BUA and SOS in early and late adolescence , while girls experience constant growth throughout childhood.
BPA has been associated with hypertension and decreased heart rate variability in the previous studies.
BPA level and the ratio of BPA-to-creatinine level were defined as log-transformed variables and in quartiles.
BP and LFSBP responses to ST in YHA and MLA were higher compared with the YLA group.
BP and neurocardiac modulation were assessed during and following each protocol.
BP and QOL were assessed pre- and post-session at baseline and following 5- and 10-weeks of Qigong.
Bp antigen specific IgG concentrations in plasma were determined using multiplex technology.
BP below 140 / 90 mmHg among treated individuals was considered adequately controlled ( < 130 / 80 mmHg among diabetics ) .
B-Pb levels in men were significantly higher than in women ( GM @number@.9μg / l vs. @number@.1μg / l ) .
BPC @number@ accelerates the blood flow recovery and vessel number in rats with hind limb ischemia.
BPC @number@ accelerates the blood flow recovery and vessel number in rats with hind limb ischemia.
BPC @number@ promotes angiogenesis in CAM assay and tube formation assay.
BPC @number@ promotes VEGFR2 internalization in association with VEGFR2-Akt-eNOS activation.
BPC @number@ promotes VEGFR2 internalization in association with VEGFR2-Akt-eNOS activation.
BPC @number@ time dependently activated the VEGFR2-Akt-eNOS signaling pathway which could also be suppressed by dynasore.
BPC @number@ up-regulates VEGFR2 expression in rats with hind limb ischemia and endothelial cell culture.
BPC @number@ up-regulates VEGFR2 expression in rats with hind limb ischemia and endothelial cell culture.
BP control among the treated was @percent@.
BP education is provided using low-literacy materials , and medication adherence is encouraged.
BPF , normalized for subject head size , was estimated with SIENAX.
BP , heart rate , SMA flow , blood glucose , and serum insulin were measured.
BPH is associated with urinary voiding dysfunction and lower urinary tract symptoms ( LUTS ) , which negatively affects quality of life.
BP load , nocturnal BP fall , and morning surge were also similar between R and C sessions ( P > 0.05 ) .
BPND was calculated using the simplified reference tissue model , with the cerebellum as the reference region.
BP responses to a 3-min head-up tilt were analysed.
BPs and the number of classes of antihypertensive agents were recorded at baseline , @number@ and @number@ months.
BPSD had no effect on hospitalizations.
BPSD was evaluated as the number of symptoms ( 0-12 ) .
BPSD were collected using the Neuropsychiatric Inventory ( NPI ) at admission and @number@ @number@ and @number@ months after hospitalization.
BP , serum lipids , body mass index , and smoking were assessed in all follow-ups.
BPs may also protect against CVD.
BP transcriptomic signatures at the single-gene and the coexpression network module levels were identified.
BPV was assessed by the read-to-read average real variability of the 24-hour SBP and DBP ( ARVs and ARVd , respectively ) .
BP was defined overall and specifically in the three spinal regions as having reported pain within the past month.
BP was measured 6×.
BP was measured by trained medical staff following standardized procedures.
BP was regulated only to a certain degree by fatness and age , with the influence being relatively small.
BP was the average of the @number@ routine outpatient clinical measurements performed closest to baseline ( first clinical visit after @date@ ) .
Braak stage V cases and Braak VI cases are significantly different from each other in terms of associated antemortem cognition ; @number@
Braak stage was also associated with cognitive decline ( difference @number@ points / yr , P = @number@ ) .
Brachial-ankle pulse wave velocity ( baPWV ) was measured to determine arterial volume distensibility.
Brachial artery diameter and velocities were measured via Doppler ultrasound at rest and during a 5-minute bout of rhythmic forearm exercise.
Brachial artery endothelial function was unrelated to MRI measures ( all p > @number@ ) .
Brachial blood pressure ( BP ) was measured and brain MRI used to determine the presence of advanced WMLs.
Brackets were bonded to the enamel premolars surface with a light-polymerized resin and stored in distilled water at 37ºC for @number@ days.
Bradyarrhythmia is a common clinical presentation.
Bradykinesia is a cardinal symptom of Parkinson's disease ( PD ) .
Bradykinesia was associated with worse spatial and variability gait parameters.
Bradykinin ( BK ) induces inflammation in rheumatoid arthritis ( RA ) .
BRAF mutation analysis was performed using DNA-based ( direct sequencing , pyrosequencing , and SNaPshot ) and IHC ( VE1 antibody ) methods.
Braf ( Q241R / + ) mice manifested embryonic / neonatal lethality , showing liver necrosis , edema and craniofacial abnormalities.
Brain activation was measured as changes in oxy-hemoglobin by fNIRS.
Brain ageing is accompanied by an increased risk of developing Alzheimer's disease.
Brain aging is characterized by cognitive decline and memory deficits that could be the result of oxidative stress and impaired cholinergic function.
Brain amyloid-β deposition was assessed with Pittsburgh compound B ( PiB ) -PET imaging.
Brain and spinal magnetic resonance imaging ( MRI ) revealed multiple enhanced lesions.
Brain areas examined included frontal , parietal , temporal and occipital cortical areas as well as the entorhinal cortex , hippocampus and brain-stem monoaminergic nuclei.
Brain atrophy may be a feasible outcome measure for AD prevention studies.
Brain atrophy rates varied nonlinearly with age , predominantly in regions of the temporal lobe.
Brain atrophy was expressed as brain tissue volume divided by total intracranial volume , yielding a percentage.
Brain atrophy was measured with cortical thickness analysis , WM abnormalities with tract-based spatial statistics , and FC with independent component analysis.
Brain Bank was established in @number@'s in the United States and Europe as a basic infrastructure for human neuroscience research.
Brain biopsy revealed the inflammatory demyelinating lesions.
Brain changes reminiscent of Alzheimer disease ( AD ) have been previously reported in a substantial portion of elderly cognitive healthy ( HC ) subjects.
Brain concentrations of γ- and α-tocopherols may be associated with AD neuropathology in interrelated , complex ways.
Brain connectivity analyses using voxels as features are not robust enough for single-patient classification because of the inter-subject anatomical and functional variability.
Brain connectivity has been assessed in several neurodegenerative disorders investigating the mutual correlations between predetermined regions or nodes.
Brain connectivity is traditionally thought to be important for creativity.
Brain-derived neurotrophic factor ( BDNF ) has been shown to be important for neuronal survival and synaptic plasticity in the hippocampus in nonhuman animals.
Brain-derived neurotrophic factor ( BDNF ) is a key protein in brain plasticity and is particularly important for survival of dopaminergic neurons.
Brain-derived neurotrophic factor ( BDNF ) is a neurotrophin essential for neuronal development and survival , synaptic plasticity , and cognitive function.
Brain-derived neurotrophic factor ( BDNF ) is an important nerve growth factor linked with development and neural plasticity.
Brain derived neurotrophic factor ( BDNF ) plays an important role in neuronal development and plasticity.
Brain development is tightly regulated by intracellular and extracellular signaling.
Brain diffusion and fluid-attenuated inverted recovery MR images revealed edematous cortical hyper-intensity , which diminished after the acute phase.
Brain diffusion MRI did not reveal abnormal changes.
Brain DNA methylation in SORL1 , ABCA7 , HLA-DRB5 , SLC24A4 , and BIN1 was associated with pathological AD.
Brain fluid attenuated inversion recovery MRI showed multiple bilateral hyper-intensity areas in the posterior white matter and left corona radiate.
Brain functional connectivity modifications represent one of the neurobiological biomarker for LLD even if to date remains poorly understood.
Brain glucose uptake declines during aging and is significantly impaired in Alzheimer's disease.
Brain images were acquired on a 3T magnetic resonance scanner using a conventional Gradient eco 3D T1-w sequence without contrast injection.
Brain imaging analyses also revealed that changes in activity across the retention interval in the putamen and related brain regions were associated with sleep spindles.
Brain imaging and biomarkers are making progress in the differential diagnoses among the different disorders.
Brain imaging and neuropsychological studies indicate elevated cortisol and other glucocorticoids are especially deleterious to hippocampus and frontal lobe.
Brain imaging data were used to model passage of biomarkers across the blood-brain barrier.
Brain imaging is recommended , and non-invasive imaging of the cervicocephalic vessels should be performed urgently and routinely as part of the evaluation.
Brain imaging might be used as a surrogate for detecting long-lasting low status of micronutrients.
Brain imaging techniques have advanced rapidly in recent years , yielding detailed structural and functional maps of the living brain.
Brain infarction was evaluated by imaging stained coronal brain sections.
Brain infarcts were rated visually.
Brain iron accumulates during aging and has been associated with neurodegenerative disorders including Alzheimer's disease.
Brain iron levels appear to be modulated by diet , with effects being highly dependent on gender.
Brain is no exception to this and deficits in cognitive functions are quite common in advanced aging.
Brain lipid signaling pathways are altered in neurologic disorders and may be viable targets for the development of novel therapeutics.
Brain magnetic resonance imaging ( MRI ) on fluid-attenuated inversion recovery revealed a hyperintense lesion in the right temporal white matter.
Brain magnetic resonance imaging scans were analyzed using FreeSurfer software.
Brain magnetic resonance imaging studies at @number@ T were performed.
Brain mast cells are mainly localized in the diencephalon , which is linked to emotion regulatory systems.
Brain maturation progresses throughout childhood into adolescence.
Brain messenger RNA expression and brain expression quantitative trait locus functionality were determined.
Brain metabolism declines with age , but cerebral blood flow ( CBF ) is less age dependent.
Brain microangiopathy increases in frequency and severity with older age , with the presence of hypertension and to a lesser extent with diabetes.
Brain microangiopathy seems to be however a complication of chronic hyperglycaemia , probably due to similar mechanisms occurring in retinopathy and other microvascular complications.
Brain morphology and cognitive ability change with age.
Brain MRIs were obtained shortly after Visit @number@ in @number@ participants ( @percent@ women , @percent@ AA ) .
Brain MRI was available in @number@ subjects without dementia or MCI ( mean age @number@ education = @number@ years ; @number@ % women ) .
Brain network changes provide valuable insights into the processes underlying senescence.
Brain network efficiency measures were generated from diffusion tensor imaging-derived structural connectivity matrices using the Brain Connectivity Toolbox.
Brain networks for both cohorts displayed a modular organization overlapping with functional domains such as executive and auditory / language processing.
Brain networks in the elderly showed decreased modularity ( less distinct functional networks ) and decreased local efficiency.
Brain networks were constructed by computing Pearson's correlations in temporal fluctuations among @number@ parcellation units followed by graph-based network analyses.
Brain pathology was assessed by MRI using normalized brain volume and lacunar lesion volume as proxies.
Brain phosphatide synthesis requires three circulating compounds : docosahexaenoic acid ( DHA ) , uridine , and choline.
Brain plasticity is vulnerable to the normal aging process and affected in schizophrenia : brain-derived neurotrophic factor ( BDNF ) is an important neuroplasticity molecule.
Brain regions predicting executive performance included orbito-frontal , and occipito-temporal areas.
Brain reserve capacity ( BRC ) refers to preinjury quantitative measures such as brain size that relate to outcome.
Brain reserve hypothesis and cognitive reserve hypothesis are discussed , which might open the new perspective to overcome the memory impairment of the elderly.
Brain response during processing of fearful faces was measured by functional magnetic resonance imaging in @number@ older adults and was correlated with level of optimism.
Brain sensitivity to metabolic disorders is demonstrated by the effect of homocysteine on metabolic pathways , on brain integrity and on the cognitive capacity.
Brains from immunized rabbits showed no signs of encephalitis.
Brains from patients with juvenile onset are usually more atrophic than those with adult onset.
Brains from patients with late onset of symptoms might show changes occurring in usual aging in addition to those characteristically observed in Huntington disease.
Brain source localization was utilized to study the modulations in the early N170 event-related-potential component.
Brain-specific gene inactivation of IGF-1R and IRS-2 resulted in similarly long-lived phenotypes indicating that control of longevity is possible by selectively targeting the brain.
Brainstem responses were also a more robust predictor of individuals ' MCI severity than cortical activity.
Brainstem tangles were associated with more depressive symptoms in those without cognitive impairment but with fewer symptoms in those with mild cognitive impairment.
Brain steroids serve as local regulators of neural development and excitability.
Brain structural imaging was performed using a @number@.5-T scanner.
Brain structures continue to have high heritability into late life , although the genetic component of the variance does decrease with age.
Brain thiamine homeostasis has an important role in energy metabolism and displays reduced activity in Alzheimer's disease ( AD ) .
Brain tissue changes accompany multiple neurodegenerative and developmental conditions in adolescents.
Brain tissue regions of interest showed expected age-related decrease in volume ; cerebrospinal fluid-filled spaces showed increase in volume for both groups.
Brain trauma , neurodegenerative diseases , and psychiatric disorders pose enormous burdens at both personal and societal levels.
Brain ventricle sub-volumes were quantified from three-dimensional T1-weighted MRI using semi-automated software.
Brain was discussed by @percent@ of the participants.
Brain weight was related to all domains independent of specific neuropathologies.
Branched-chain amino acids ( BCAAs ) are important nutrient signals that have direct and indirect effects.
Branching DNA technology is used to amplify the signal , which is detected by Luminex technology.
Brazil has an aging population , with an associated increase in the prevalence of chronic diseases.
BRCA1 variant I42V also abrogated the binding of BRCA1 to OLA1.
Breakdown is as follows.
Breakdown of structural connectivity measured with DTI may impact cognitive performance during early AD.
Break-even analyses estimated the maximum acceptable campaign cost to be $ 14 , 870 , 000 , which was comparable to the benchmark ICER.
Break-even analysis showed that the system cost of Model @number@ had to be under $ 187 , 500.
Breaks and MVPA had strongest independent associations with LEF.
Breakthroughs in bio-gerontology and in bio-medicine have created the possibility of an increasingly differentiated idea of normal ageing.
Break-up time ( BUT ) , corneal staining , McMonnies questionnaire and the Schirmer I test were applied to both groups.
Break-up time was shortened significantly in @number@ patients examined.
Breast and colorectal screening , fruit and vegetable consumption , physical activity , and smoking were recorded at Wave @number@
Breast cancer BM are increasing due to the aging population , detection of subclinical disease , and better control of systemic disease.
Breast cancer cells ( MCF-7 ) were more affected by tested compounds than prostate cancer cells ( PC3 ) .
Breast cancer is a heterogeneous disease whose molecular diversity is not well reflected in clinical and pathological markers used for prognosis and treatment selection.
Breast cancer is a hormone-dependent cancer and usually treated with endocrine therapy using aromatase inhibitors or anti-estrogens such as tamoxifen.
Breast cancer is often studied in young women ; however , much investigation remains to be done on breast cancer in our expanding elderly population.
Breast cancer is the most common malignancy and the most common cause of cancer death in elderly women.
Breast cancer is the most prevalent women's cancer , with an age-adjusted incidence of @number@ per @number@ US women.
Breast cancer is the second most frequent type of cancer worldwide and is the most common malignant disease among women.
Breast cancer occur both in hereditary and sporadic forms , and the later one comprises an overwhelming majority of breast cancer cases among women.
Breast cancer progression and metastasis are driven by complex and reciprocal interactions , between epithelial cancer cells and their surrounding stromal microenvironment.
Breast cancer represents the second most frequent etiology of brain metastasis ( BM ) .
Breast cancer risk was also examined in relation to a polygenic risk score ( PRS ) for each of the reproductive aging phenotypes.
Breast cancer was also the leading cause of cancer deaths and DALYs for women ( @number@ @number@ deaths and @number@ million DALYs ) .
Breast density is considered a structural property of a mammogram that can change in various ways explaining different effects of medicinal treatments.
Breast-feeding duration and exclusivity were not consistently associated with the risks of overweight and obesity at the ages of @number@ @number@ and @number@ years.
Breast-feeding has been suggested to be associated with lower risks of obesity in older children and adults.
Breastfeeding promotion should start during pregnancy , advising women about benefits for the child in receiving human milk.
Breast , prostate , and colorectal cancers were the most common types of cancer among survivors , accounting for @percent@ of diagnoses.
Breast specimen after surgery was prepared with part-mount sub-serial section , and residual tumors were microscopically outlined , scanned and registered by Photoshop software.
Breast volume was also assessed.
Breast WAT inflammation , a process that can potentially be targeted , may help to explain the high incidence of estrogen-dependent tumors in postmenopausal women.
BRF1 associates with BDP1 and TBP to form the transcription factor IIIB ( TFIIIB ) , which recruits Pol III to target genes.
BRI2 containing BRICHOS-domain was increased up to 3-fold in AD hippocampus ( p = @number@ n = 14 / group ) .
Brick veneer homes showed smaller diurnal changes in temperature than other building materials.
Bridge employed reported increased ' occasional ' frequency of musculoskeletal injury risk factors , while both groups reported similar overall ratings of work-related exertion.
Bridgetown , São Paulo and Mexico City demonstrated a statistically significant association between aging and tooth loss.
Bridging capital scores had the higher disparity , specifically in participation in community organizations and the representation of their interest in them.
Bridging these gaps is crucial for enhancing understanding of this understudied population.
Brief and minor adverse events were reported.
Brief assessments of consciousness and attention should be considered for inclusion in fall prediction.
Briefly discusses the history of the search of thermodynamic approach to explain the origin of life , evolution and aging of living beings.
Briefly , MI is performed under the assumption that the unobserved 400-m gait speed of noncompleters is left-censored from a normal distribution.
Briefly , the proposed method exploiting mRNA and microRNA expression trains Random Forests on known interactions and subsequently it is able to predict novel ones.
Brief nutrition screening tools are desired for research and practice.
Brief vignettes were used to assess knowledge about how POLST orders guide medical treatment.
Bringing together literature on care from social gerontology and economics , we report the findings of a mixed-methods project exploring networks of informal caring.
Brinzolamide / brimonidine was generally well tolerated , with a tolerability profile that was consistent with its individual components and with no unexpected safety findings.
British Columbia's health care system is facing challenges related to rural access to care and an ever increasing demand for services.
Britt.
Broadband ultrasound attenuation , speed of sound and stiffness index were determined by calcaneal quantitative ultrasound ( QUS ) .
Broader work looking at the impact of social connectedness , loneliness and support on survival should be supported.
Broad implementation of A1c to diagnose dysglycemic states may substantially alter the epidemiology of these conditions in older Americans.
Broad implementation of context-free missing data encoding may enhance the possibilities of data sharing and pooling , thus allowing more powerful analyses using existing data.
Broad range of endocrine and metabolic disturbances like obesity , hyperinsulinemia as well as dyslipidemia might be responsible for PCOS-associated oxidative stress.
Broad-spectrum electrical impedance spectroscopy demonstrates increased sensitivity to electrode damage compared with single-frequency measurements.
Broad use of screening methods has lowered colorectal cancer development by about @percent@.
Broilers were challenged via the trachea at @number@ and @number@ wk of age with various combinations of LPS , HuSA , and RGG.
Bronchial asthma is one of the most common chronic diseases worldwide , and by definition not expected to recover with aging.
Bronchoalveolar lavage ( BAL ) is most important for cultural identification and susceptibility testing , and facilitates diagnosing other pathogens.
Bronfebrenner's theory was used to understand stakeholder perspectives and suggest interventions within four identified spheres of influence - individual , household , community and services.
Brookmeyer used incidence rates from several published studies , whereas the CHAP investigators applied the incidence rates observed in their own cohort.
Brown adipocytes are responsible for thermogenesis and could therefore counter obesity by increasing energy expenditure.
Brown men and women also reported higher levels than White men in Brazil.
BRS of @percent@ of the subjects remained unchanged , of @percent@ decreased , and of @percent@ improved.
BRS was defined as being normal , moderate , or severe alteration at each evaluation.
Bruch's membrane / choroid , a site of tissue damage in AMD , contains high concentrations of glycosaminoglycans , including HS.
Bruising was not observed.
Bruno Vellas tells Fiona Fleck why governments must act now to help older people stay fit and healthy.
Bruton's tyrosine kinase ( BTK ) is a member of the Tec family of cytoplasmic tyrosine kinases involved in B-cell and myeloid cell signaling.
Bryostatin-1 and picolog prolonged activation of Erk in fibroblasts to promote cell survival.
BS and FA group J arise from mutations in the BLM and FANCJ genes , respectively , which encode DNA helicases.
B ) Short and long-term dynamics of body weight and composition.
B-Sod2 ( - / - ) showed perinatal death , along with severe growth retardation.
BSP and PR immediately after exercise were not significantly different among the groups ( p = @number@ and @number@ respectively ) .
BT antibody titers were @number@ @number@ and more than @number@ mU / mL on the mouse diaphragm assay.
BTL was moderately and positively related ( P = .003 ) to the ABC Scale and negatively related ( P = .017 ) to TUG.
BT steaks had WBSF of @number@ N while C steaks had WBSF of @number@ N ( P = 0.09 ) .
BTT analysis involved principal axis analysis , in which the principal axis was the first principal component according to a principal component analysis technique.
BTX-A and NS reduced pain and disability one month after injection.
B-type natriuretic peptide consistently improved prediction in AGES and RS.
B-type natriuretic peptide may serve as a benchmark to evaluate novel putative AF risk biomarkers.
BubR1 also helps promote the establishment of stable kinetochore-microtubule attachments during prometaphase.
BubR1 protein levels in oocytes from younger and older women were compared with the use of immunoblotting.
Buccal and leukocyte derived DNA obtained from samples collected at the same time period were analyzed for telomere repeat mass ( TRM ) .
Buccal cells are commonly sampled for DNA isolation and thus may present a non-invasive alternative for telomere measurement.
Buccal TL was measured using monochrome multiplex quantitative real-time polymerase chain reaction.
Budget impact models that estimate the amount of additional costs and potential savings are being increasingly used by policy-makers.
Building capacity within and across the other sections in APHA will be our greatest challenge over these next few years.
Building on animal models and available theories , we promote the expansion-renormalization model for plastic changes in humans.
Building on research by Hirdes et al.
Building on the work of Houseman and colleagues ( Feature-specific penalized latent class analysis for genomic data.
Built environment measures were created for @number@ buffers around participants ' residential address.
Bulk staining and the cutting-grinding technique were used to separate in vivo MDx from microcrack artefacts induced post mortem by the milling procedure.
Bull. , @number@ 1915-1918 , @number@ ] .
Bullous pemphigoid is a blistering skin disease characterized by autoantibodies against the NC16a domain of bullous pemphigoid @number@
Bullous pemphigoid is a rare autoimmune muco-cutaneous disorder involving particularly aged adults.
Bunina bodies and hyaline inclusions were not seen.
Bupropion has been shown to improve the adverse sexual effects associated with antidepressant use ; however , data are limited.
Burden and mood-related symptoms explained the positive differences and residuals , while pain , self-perceived depression and cognition determined the negative ones.
Burden of microdamage in vivo bone is determined by balance of generation and repair of microdamage.
Burdens associated with aging are expanding as longevity increases.
Burdens of unhealthy aging associated with chronic noncommunicable and other age-related diseases may be largely preventable with lifestyle modification , including diet.
Burden varied between countries and was likely influenced by population size , surveillance system , healthcare provision , and vaccine coverage.
Burden was measured with a modified version of the Zarit Burden Inventory.
Burden was the only significant predictor for internal anger expression ( @percent@ explained variance ) .
Burm. f. ) juice beverages enriched either with noni ( Morinda citrifolia L. )
Burn injury to individuals older than @number@ years occurs with a frequency that is disproportionate to that of all other victims except the very young.
Burn-out symptoms were rarely experienced.
Burns continue to remain a major healthcare problem in the United States and globally.
Burr hole trepanation and twist drill craniostomy have become the therapeutic standards with craniotomy being rarely used for recurrent cases.
Bursa cells pretreated with BMP-12 and seeded in ceramic scaffolds formed extensive bone , as well as tendon-like tissue in vivo.
Bursa-derived cells also formed a fibrocartilagenous tissue in the ceramic scaffolds.
Bursa-derived cells expressed markers of tenocytes when treated with bone morphogenetic protein-12 ( BMP-12 ) and assumed aligned morphology in culture.
Business leaders in industries where labor substitution is common are encouraged to seek friction corrected estimates of return on investment.
But again , data has accumulated that cautions against the potential use of the FOXO activators in these settings.
But again , these promising results are yet to be replicated in other samples.
But among those older foreign-born who immigrated at middle and older ages , naturalized citizens report worse health compared with noncitizens.
But Angle Max. and Angle Diff. were mainly affected by sun exposure.
But antiresorptive treatment led to fewer mineralized lacunae and fewer but larger osteons signifying rejuvenated bone.
But complete inhibition of butyrylcholinesterase activity was achieved only when the DSM concentration was at least 1500-fold higher than the enzyme concentration.
But currently , only analysis of autopsied brains can provide this data and thus enable proper evaluation and explanation of the outcome of clinical trials.
But does this catchphrase still have currency for the men and women in this cohort who are mostly now over the age of fifty ?
But even with this advanced technique the required length could not be covered.
But falls are common.
But for anti-aging applications , these hurdles are irrelevant.
But for maximal patient comfort , a topical anesthetic prior to the procedure is recommended.
But further data are needed before adopting them for routine use in such conditions.
But , future increasing education could mitigate some increases in disability rates.
But how can a drug that slows aging become approved and make it to market when aging is not defined as a disease.
But how does this translate to seniors ' adoption and acceptance of technology ?
But how glycolysis regulates H3T11 phosphorylation remains unclear.
But how statins might influence tendons is not clear.
But how the bmMSCs lose osteogenic capability in aging is unclear.
But if women age slower , why then is it women who have menopause ?
But impact of folic acid supplementation on prevention or delay of dementia is a matter of debate.
But in ageing individuals , it has been observed to have greater impact , manifesting in functional , psychological and social limitations.
But in most studies , no single condition explains this association.
But in old age group , the expression of MMP-1 / TIMP-1 was higher than the young groups.
But it had no significant effect on the carbohydrate antigen 19-9 level.
But , it is still unclear to what extend age-associated cognitive decline can be related to BFCS in normal aging.
But it was not statistically significant ( p = @number@ ) .
But James had much more difficulty standing and was actually quite competent while in motion.
But little is known about the health consequences.
But magnetic field seems to have more beneficially and statistically significant effect than does CWT.
But midfacial filler injection does not only improve the malar area.
But more and more studies have also demonstrated right hemisphere advantage for some language tasks with certain participants.
But no independent association was found between orthostatic hypertension or hypotension and a decreased estimated glomerular filtration rate in hypertensive patients.
But not all of them have the symptoms like pain and decreased joint motion.
But not all stimulants are the same.
But older age is commonly considered to adversely affect practice-dependent functional plasticity and , thus , functional and rehabilitation outcome after acquired brain injury.
But our results provide evidence that reduced enjoyment of life may be related to the future disability and mobility of older people.
But post-reproductive life span poses a paradox for traditional theories of life history evolution.
But remarkably , the extract conferred an ability of the wrinkled-skin fibroblast lattices to fully contract ( to @percent@ ) .
But severe limitations showed the difficulty of overcoming the historical backwardness of Spanish social policy.
But significant interassay and interlaboratory variabilities hinder the widespread clinical applications of CSF biomarkers.
But suppose both are correct ?
But symptoms and signs of septic arthritis and spondylitis are an important medical emergency , with high mortality and morbidity.
But the author rather considers the uncertainty of aging a positive message.
But the BBB permeability at the late stage of acute intracerebral hemorrhage ( ICH ) patients is uncertain.
But the cancer hypothesis is problematic as well.
But the direct professional programs can be planned after solution of the existing moral and social dilemmas.
But the driving quality can be affected by aging.
But the effects of HA only lasted for a relatively short duration.
But the high toxicity of Se limits its application.
But the life-extending effect of severe CR is limited by starvation.
But the overall cost of care was substantially higher than the patients ' mean salary ( p < 0.0001 ) .
But the paper loses focus with discussions of \ "ageism \ " , the compression of morbidity , and healthy communities.
But the role of high circulating follicle-stimulating hormone ( FSH ) in postmenopausal syndrome is not clear.
But the role of menin is not clear.
But they still maintained a similar level of self-perceived CP traits when compared with young participants.
But this pattern is not universal.
But this will require further research on CB waste effects on non-target organisms including humans.
But , to date , no research has been conducted in the field of motor skills.
But treatment should not be focused only on penile-vaginal intercourse.
But up to now the involvement of central sensitization in adhesive capsulitis has not been studied yet and remains speculative.
BUT values decreased and corneal staining increased with age and correlated with the levels of diadenosine polyphosphates ( p < @number@ ) .
But very little actually exists in literature concerning their detectability and how long they last.
But very little is known about the role of TFAM in cancer development.
But vitamin D insufficiency is more prevalent in children with recurrent tonsillitis group ( @percent@ ) .
But we were also able to identify new themes that have rarely been mentioned in previous studies of successful aging.
But what are the challenges that need to be addressed in its implementation in the clinic ?
But what are the factors which help people reach their ninetieth birthday and beyond in good condition ?
But what is the possible role of the mass proliferation of digital devices in supporting healthy living and active ageing ?
But what will cause human death , when aging will be abolished ?
But , when skin distribution was estimated by measuring inhibition of cholinesterase activity , the results were poorly reproducible.
But where to start ?
But which of these discoveries will apply to ageing in humans ?
But why is this the case ?
But yet , the interconnected nature of homeostatic wiring can provide organisms with the means of compensating for the decline of one subsystem.
Butyrate , octanoate , or lithium did not inhibit AA activation by Acsl4.
BvFTD patients showed less accurate performance only on the conjunction search task , but slower response times than NC on all three tasks.
BvFTD patients showed widespread decrements in [ ( @number@ ) C ] ABP688 BPND throughout frontal , temporal and subcortical areas.
B vitamins may lower the risk of dementia , yet epidemiological findings , mostly from countries with folic acid fortification , have remained inconsistent.
BV.vert / TV decreased significantly faster with age for women than for men.
By 1979-83 , male patterns in Australia and US were bimodal , but Japan's was trimodal , including a middle-age peak reached in 1994-98.
By 4-6 mo , we could no longer detect a difference in recovery.
By acting in the brain and periphery , BDNF increases insulin sensitivity and parasympathetic tone.
By adopting these recommendations , we obtained a @percent@ drop in section detachment.
By advancing our understanding of MV biology , we expect that the developed platform will lead to improved blood product quality and transfusion safety.
By age @number@ fatal intersection crash risk for all drivers was almost doubled.
By age @number@ years , more than @percent@ of men and women had one or more biomarker abnormalities.
By ' aging ' of garlic , some adverse reactions of garlic can be eliminated.
By aging process , sexual behaviors of elderly people may change.
By altering the dose of Δ40p53 in ESCs , we identified a critical role for this isoform in maintaining the ESC state.
By a minimal surgical access , we get a suitable cheek lift with the improvement of nose-labial folds , mandibular edge and neck contour.
By analyzing IgG glycosylation in @number@ individuals from four European populations , we have revealed very complex patterns of changes in IgG glycosylation with age.
By analyzing the morphological profiles , we generated the first comprehensive map of the aging human facial phenome.
By applying the Chaimowitz's test , the presence of incompetence for sodium reabsorption in TALH in healthy old people was documented.
By approaching cognitive health holistically , the patient will be primed to receive the maximum benefit from cognitive remediation training.
By a systematic comparison of wound healing conditions , the large-scale collaborative FP7-EU project RESOLVE has addressed these difficulties in a successful way.
By becoming truncated during cell division , telomeres protect essential genes from being shortened and thus inactivated.
By binding to allele ' A' , HSF1 abrogates the enhancer effect of the locus as validated by reporter assays.
By calling attention to the commonalities of these two states , we hope to inspire new approaches for dissecting microglial mechanisms.
By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals.
By combining practical knowledge and active learning strategies to work through real-life scenarios , the Kupuna Adult Care Home project is a promising training model.
By combining the information from the two views , we estimated two acoustic properties : speed of sound and attenuation coefficient.
By comparing co-existing immature and mature beta cells within healthy islets , we stand to learn how to mature insulin-expressing cells into functional beta cells.
By comparing eyebrow shape and position in both young and mature women , this study provides objective data with which to plan forehead rejuvenating procedures.
By comparison , gray widoweds are the most advantaged singles.
By comparison , traditional parameters and absolute procalcitonin failed to predict treatment response ( P > @number@ ) .
By complex mechanisms , it regulates the homeostasis of inflammatory processes and tissue repair mechanisms.
By conditioning on polymorphisms associated with the @number@ phenotypes , we identified @number@ loci associated with increased AD risk.
By conducting retrospective chart review , we found neurodegenerative diseases are more prevalent in elderly patients with chronic eczematous dermatitis.
By consensus , @number@ new recommendations were adopted.
By consensus , the authors selected the most relevant criteria for the final set of criteria.
By consequence , it is associated with a high vulnerability and reduced ability to maintain homeostasis.
By considering studies on disuse in young adults and training in elderly adults , future research directions are proposed to help resolve the problems.
By considering these morphological changes in the pelvis simultaneously , the hip axis can move only within a narrow area.
By contrast , a control group , which did not practice , showed no significant increases in these regions.
By contrast , age was positively related to OPL and PR ( P < @number@ ) .
By contrast , atherosclerosis and cerebral amyloid angiopathy pathology were associated with a lower level of cognition but their effects were relatively stable over time.
By contrast , carriers of the higher expression homozygous long allele ( L / L ) genotype may respond at lower concentrations.
By contrast , CB1 availability was relatively increased in nigrostriatal , mesolimbic , and mesocortical dopaminergic projection areas.
By contrast , children appeared to rely mainly on recollection concordant with their conservative decision criteria across tests.
By contrast , concurrent arm swing-stepping led to limb incoordination in both patients and in healthy elderly controls.
By contrast , C-peptide concentration was not associated with the incidence of cardiovascular events or the development of retinopathy.
By contrast , curvature decreased with aging in relation to the smaller percentwise opening angle differences.
By contrast , DBSI-derived FA was similar for both groups.
By contrast , donor RBCs stored @number@ days or more demonstrated distinct clustering as a function of storage time and irradiation.
By contrast , education was a strong independent protective factor against cognitive deficits.
By contrast , estimated survival past sixty decreased over the same period.
By contrast , explicit recognition of the three groups differed.
By contrast , exponent @number@ provided better prediction for children ≥3 months to @number@ year than exponent @number@
By contrast , expression of these factors in adult islet β cells was not affected by Ex-4 exposure.
By contrast , FIT sensitivity was uniformly excellent for CRC and uniformly poor for nonadvanced adenomas , regardless of their location.
By contrast , from the age of about @number@ upward , adults were characterized by a more intensely proactive use of these strategies.
By contrast , GAD participants showed PFC decreases during negative words and no differences in amygdalar activity across word types.
By contrast , gelatin ( > 120 kDa ) ingestion did not bring a significant change compared to model mice.
By contrast , high-memory believers seemed to rely more on executive-like processes involved in cognitive control.
By contrast , Htr2b mRNA was present at moderate levels in these cells.
By contrast , in older subjects , TL was significantly longer in those with high aPWV ( P = @number@ ) .
By contrast , in pre-menopausal women , cortisol changes seemed to be modulated by passive and reactive behaviors such as Submission and Assertion.
By contrast , in subjects with A. fumigatus allergies , specific Th2 cells were strongly expanded despite the presence of specific Treg.
By contrast , intake of small amounts of fish oil with antioxidants extended the lifespan.
By contrast , in this study we apply the Universal PaceMaker ( UPM ) model to investigate changes in DNA methylation during aging.
By contrast , it was not different between both groups in the temporal cortex , a less vulnerable structure compared to the putamen.
By contrast , living with children and regarding children as filial decreased physician visits.
By contrast , LPP amplitude increases were observed only in older listeners.
By contrast MEPs in older participants were less specifically modulated.
By contrast , more activity was found in dorsal anterior cingulate gyrus for the high-memory believers.
By contrast , neglect patients exhibited a symmetrical pattern of priming between the left and right visual fields.
By contrast , no deviation was observed in both non-neglect and healthy groups , for the visual and the visuo-haptic modalities.
By contrast , older adults did not improve the timing of gaze anchoring termination for either practice condition , thereby failing to break gaze anchoring.
By contrast , only the emotional regulation and humor components of the SAWS were consistently positively associated with those subscales.
By contrast , opponents and sceptics tend to focus on needs-based justice and social inequalities within age groups.
By contrast , other VOCs persisted in the gas phase for at least @number@ h , particularly furans , carbonyls , and nitriles.
By contrast , overexpression of CaMKII increased HR and reduced arrhythmias.
By contrast , primary macrophages , which do not exhibit activated mTOR signaling , proved relatively resistant to PS-NH2-induced toxicity.
By contrast , sexually outbreeding species maintain abundant genetic polymorphism within populations.
By contrast , sustained beta desynchronization , indicative of sensory reactivation and episodic reconstruction , was correlated with contextual memory performance for older adults only.
By contrast , the amounts of the synthases were increased in the lung tissues and sputum cells of patients with COPD.
By contrast , the beneficial effects of different sources of intact proteins in relation to exercise need further investigation.
By contrast , the daughters ' cortical thickness did not predict their mothers ' cortical thickness.
By contrast , the effect of aging was apparent in both conditions.
By contrast , the energy sensors PTEN and AMPK connected to the nodes in the ERiQ subnetwork.
By contrast , the frequency of sadness remains stable over most of adulthood and begins to increase in old age.
By contrast , the glabellar fold and the labiomental sulcus have no direct relation to the boundaries of facial fat.
By contrast , the glabellar fold shows the most simple anatomical architecture.
By contrast , the hypertrophic type was present in relatively younger patients and was associated with an increased index of acetabular dysplasia.
By contrast , the immunolabeled nuclei of human and catfish germ cells condensed into a single mass , after which they lost immunoreactivity.
By contrast , the induction did not affect internal ( or external ) details for picture description.
By contrast , the intact implicit memory of the two clinical groups could be used in rehabilitation.
By contrast , the loss of pro-T cells is intrinsic to the hematopoietic compartment , and is sufficient to drive premature involution.
By contrast , the number of tanycyte cell bodies did not appear to change throughout life.
By contrast , the rates have been declining for cervix and stomach cancer.
By contrast , there was no age-related decline of DAT in the thalamus.
By contrast , the roles that miRNAs have in the maintenance of stem cells are less well understood.
By contrast , these components are not essential for the ability of miR-17-92 to evade Myc-induced apoptosis.
By contrast , these same studies also demonstrate that trabecular bone loss begins in sex hormone-replete young adults of both sexes.
By contrast , the telephone self-test had lower diagnostic accuracy ( AUC = @number@ @percent@ CI : @number@.64-0.86 ) .
By contrast , what is demonstrable is that interventions in model organisms can improve late-life health and extend lifespan.
By creating fertility reserves , women are now able to become pregnant using their own eggs , even after menopause.
By culling cells with dysfunctional telomeres , p53 plays a critical role in protecting tissues against the effects of critically short telomeres.
By @date@ , a total of @number@ individuals had died and had brain autopsies that were approved by board-certified neuropathologists.
By day @number@ serum-deprived cells grown on transwells secreted Fib3 basally into the matrix.
By decoupling the matrix-level effects due to NEG and intracortical porosity , we are able to directly determine the effects of NEG on fracture toughness.
By decreasing immune surveillance , latent lymphedema ostensibly facilitates human papillomavirus infection and carcinogenesis.
By demonstrating top-down signal transmission in AV synesthetes , we provide direct support for the disinhibited feedback model of synesthesia.
By determining the mutational history of individual cells , we uncover a novel mutational signature in healthy aging endocrine cells.
By doing so , health professionals will be best equipped to assist their patients to live well into death.
By electron microscopic analyses , the width of fαS formed in MSA-CSF was significantly greater than others.
By electron microscopy , discrete straight filament aggregates were detected in some neurons in the hippocampus.
By employing a metabolite-alkyne-tagging strategy it is clarified that 3-hydroxyhexane-2 , 5-dione is further metabolized to non-glycating species in human blood.
By establishing these centers , uniform accessibility for the quality of medical care for the elderly in each region is expected.
By exchanging this element participants either stepped on hard surface or unexpectedly on soft surface which caused a perturbation in gait.
By extending this finding at protein level we found that BTC is abundantly produced by FDC-S cells and surrounding stromal cells.
By extrapolation , these findings may be of broader significance for age- and disease-related dysfunctions associated with oxidant stress.
By far , dementia technology received the most research attention.
By far , food insecurity was the most salient influence on depressive symptoms.
By far , rodent models have been employed most often in these endeavors.
By far the most important cost item is the cost of institutional care : about @percent@ of the costs.
By finger photoplethysmography , LL-BFR prompted higher systolic and mainly diastolic blood pressure increments in many sets.
By FISH , @percent@ of DLBCLs showed IGH@ rearrangements , but PAX5 was unaffected.
By forming mTOR complex , it regulates cellular activities by phosphorylating its downstream proteins , such as S6 protein kinase and 4E-BP1.
By gene expression profiling , we identified the crucial involvement of inflammatory and JAK / STAT pathways in TNFα-mediated senescence.
By genetic approach , we demonstrated that loss of Plekho1 in osteoblasts could promote the Smad-dependent BMP signaling and alleviated the age-related bone formation reduction.
By global gene expression profiling , we identified the inflammatory marker pentraxin-3 ( PTX3 , TNFAIP5 , TSG-14 ) as a CEBPD target in astrocytes.
By harnessing this understanding we are poised to address the esthetic concerns of aging hair.
By history , the proband's father had developed cognitive symptoms at age @number@ and died at age @number@
By immunofluorescence imaging of bipartite synapses from AD subjects , we detected tau protein in @percent@ of presynaptic and @percent@ of postsynaptic terminals.
By including leisure activities , it considers the changed living conditions of modern-day older adults.
By inhibiting the production of ARMs , they could reduce age-related cognitive and physical declines.
By inhibiting this effect , antimuscarinics may decrease OAB symptoms and DO without affecting the voiding contraction.
By interacting with cardiolipin , SS-31 prevents cardiolipin from converting cytochrome c into a peroxidase while protecting its electron carrying function.
By interviewing @number@ persons living with dementia and their @number@ care partners , we explored the meaning and experience of change surrounding mealtimes.
By investigating the biology of much simpler model organisms , it is often possible to answer questions that are unreachable at the clinical level.
By itself this will answer some burning questions in gerontology.
By late childhood , posterior cortical-subcortical connections were similar to adults.
By linking differential gene expression with smoking-related disease phenotypes , we demonstrated that stroke and pulmonary function show enrichment for smoking-related gene expression signatures.
By linking these data and excluding the missing data , @number@ males and @number@ females remained as the subjects of our study.
By maintaining both the integrity and the expression of the mammalian genome , SIRT6 thus serves several roles that parallel Sir2 function.
By manipulating skin cooling , RF can also be used for heating and reduction of fat.
By manipulating the environment at the nanoscale , the rate and distribution of healing can be controlled.
By manipulating the spatial contiguity of stimuli , we also evaluated whether such priming requires the creation of perceptually unitized representations.
By matching data from bioinformatic algorithms , we found @number@ miRs predicted to bind the @number@'-UTR of ALX / FPR2.
By means of comprehensive geriatric assessments ( CGAs ) , an evaluation can be made of the different palliative care needs of nursing home residents.
By means of the ULCEAT method the target users and the use environment were re-established in an earlier study.
By measuring the changes in diffusion parameters over this period on a per-voxel basis , we hope to provide unique insight into neurodevelopment.
By multiple regression analyses season was identified as the only independent predictor of PSL-PSU relationship.
By nine months of age , P301S mice with different ApoE genotypes display distinct phosphorylated tau protein ( p-tau ) staining patterns.
By noncontrast MRI , intracranial neoplasms were most suggestive of meningiomas.
By non-invasively examining the state of the thalamus we can monitor development in the preterm period.
By @number@ for the first time in U.S. history , almost half of elders will be from ethnic minority groups.
By @number@ in the United States alone , the estimated cost from visual impairment due to GCA will exceed US $ 76 billion.
By @number@ it is predicted that @percent@ of the population will be aged @number@ and over.
By @number@ it is projected that there will be approximately @number@ million new cancer cases and @number@ million cancer deaths per year.
By @number@ life expectancy without cognitive impairment had increased to @number@ years for men and @number@ years for women.
By @number@ more than @number@ JAAM-affiliated hospitals had implemented this type of EM.
By @number@ more than @number@ million people will have been diagnosed with GCA in Europe , North America , and Oceania.
By @number@ NAMBTS issued @number@ single-donor PLT doses per year , @percent@ of all PLT units.
By @number@ nearly @percent@ of the US population will be older than @number@ years.
By @number@ @number@ Waves had been completed ; both face-to-face and telephone personal interviews were conducted.
By @number@ only @percent@ of older adults responded don't know / not sure , with @percent@ refusing to answer sexual orientation questions.
By @number@ @percent@ of her population will be aged @number@ years and above.
By @number@ @percent@ of residents were diagnosed with depression , @percent@ of whom received an antidepressant.
By @number@ the 80 + generation will increase by at least @percent@ and in @number@ by at least @percent@ , compared to @number@
By @number@ the global cancer burden is expected to rise by @percent@ owing to the increasingly elderly population.
By @number@ the number of older adults within the United States will have doubled to approximately @number@ million.
By @number@ the number of older persons across the globe will exceed the number of younger people for the first time in history.
By @number@ there will be a @number@.7-fold increase in the number of hip fractures in Taiwan.
By @number@ there will be @number@ million Chinese citizens aged 65 + , @number@ million of whom will be 80 + .
By @number@ the United States is expected to experience a nursing shortage ; in Hawai'i this shortfall is forecast to be @number@ professional nurses.
By @number@ the US population is expected to increase by @percent@.
By @number@ years , a new compact bone containing osteoblasts and osteocytes was present in all specimens in the deep ( osseous ) aspect.
By @number@ years , there was a consistent power reduction specific to the low-frequency band.
By optimizing all stages of the surgical patient management , from diagnosis to recovery , prognosis of high-risk surgical patients could be improved.
By parent- and self-report , post-HCT QoL improved for children in the lowest WMH tertile significantly more than in the other groups.
By pharmacological approach , we showed that osteoblast-targeted Plekho1 siRNA treatment could enhance Smad-dependent BMP signaling and promote bone formation in aging rodents.
By preventing and treating malnutrition , health care systems should be able to reduce overall health care costs.
By probing the intersection of age , sexuality , and gender , my analysis is informed by both personal and professional experiences.
By promoting oxidative stress , the intracellular accumulation of non-heme iron outside of binding complexes contributes to chronic inflammation and interferes with normal brain metabolism.
By providing a range of services to all residents , Lifelong Communities allow individuals to age in place.
By reducing risk factors and with measures which induce neuroplasticity successful aging can be supported.
By reducing UV-induced inflammatory responses and inhibiting extracellular matrix remodeling , PL demonstrates some protective effects against photoaging and PUVA induced phototoxicity.
By responding positively to fat and alcohol and guiding further neuronal development , GAL potentiates a long-term propensity to overconsume fat and alcohol.
By revealing sex-dependent hippocampal alterations , our data may provide causal explanation to APPxPS1 females ' memory deficits.
By ribonucleoprotein immunoprecipitation , we also established that Mbnl1 binds specifically to the INSR ( insulin receptor gene ) RNA.
By sample pretreatment with proteases , HEL was successfully detected in oxidized LDL , oxidized serum , and rat serum.
By SAM ( significance analysis of microarrays ) , we identified @number@ genes that discriminated young from healthy old and \ "AD-like \ " animals.
By showing the outstanding binding reduction , presynaptic dopamine transporter ligand can provide instrumental evidence of AC in Parkinsonism and NMS.
By simulating the kyphotic collapse in a validated FEM , the mechanical basis of GM can be established.
By specifically detecting the addition of these variant repeats , we can directly visualize telomere elongation events in human cells.
Bystander cells may be in contact with , or distant from , damaged cells.
By stimulating glucose transport and mitochondrial biogenesis BDNF bolsters cellular bioenergetics and protects neurons against injury and disease.
By strong SIRT1 overexpression in sir2Δ cells , we found that specific molecular phenotypes of the mutant revert almost to a wild-type condition.
By studying cytosine methylation patterns in peripheral blood DNA we identified thousands of large between-twin differences at individual CpGs.
By studying primary isogenic murine embryonic fibroblasts , we tested the hypothesis that Plk3 functions as a component in the hypoxia signaling pathway.
By studying single cells , we show that Cdk activity persists after DNA damage until terminal cell cycle exit.
By studying the loci that contribute to human longevity , we aim to identify mechanisms that contribute to healthy aging.
By studying these individuals , they hope to unravel the genetic signatures that promote healthy ageing and long life.
By synthesizing results from diverse domains , we hope to provide a genomic-era conceptual framework in which this important connection can be investigated and understood.
By the age of @number@ @percent@ of the patients had needed at least one shunt revision , @percent@ by the age of @number@
By the age of @number@ years , @percent@ had values > 300 μg / l.
By the analysis of linkage disequilibrium decay in the haplotype block we estimated the time when the first ancestor to carry both genetic variants emerged.
By the end of2012 , more than @number@ in @number@ elderly women had consulted a physician for CMC1 OA over the last @number@ years.
By the end of @number@ participants were aged 60-75 , and almost all of them retired during follow-up.
By the proportional subdistribution model , age was a significant risk factor only for liver-unrelated death.
By the same definition , a high response rate ( @percent@ ) was maintained at maximum contraction at Day @number@
By the same standards , there is no need for restrictions for adult use of codeine.
By the time the process of oncogenesis has produced an advanced cancer , tumor cells have undergone extensive evolution.
By the time they reach retirement , individuals are typically highly experienced in sourcing food products and they have strong familiarity with food retailing environments.
By the weight-adjusted skeletal muscle index definition ( SMI ) , the prevalence of sarcopenia was @percent@.
By this approach we generate cross-link data sufficient to derive structural information for large and complex proteins.
By this view , high DLPFC recruitment for low-demanding tasks along with weak DLPFC upregulation at higher task demands reflects low efficiency.
By treating these contributory factors , the frequency of dizziness and dizziness-related impairment decreased temporarily in one patient and permanently in the other.
By trying to explain the sexual dimorphism in life expectancy , both biological and environmental aspects are presently being addressed.
By using a antibody , @number@ patients showed notable alterations of TDP-43 level in the nuclear or cytoplasmic compartments.
By using a co-culture system of keratinocytes / sebocytes , we found that CS exposure induced a SRB1 protein loss without affecting sebocytes viability.
By using a loss-avoidance frame , stereotype threat's negative effects can be attenuated or even eliminated.
By using a murine Alzheimer's disease model , we investigated a potential influence of disease-associated changes on gastrointestinal properties.
By using a @number@ base pair DNA label , the signal was @number@ times greater than that without labeling.
By using a two-wave cross-lagged design , findings showed a reciprocal relationship between QoL and functional limitations among older cancer patients.
By using drug , some sexual dysfunctions may be improved.
By using haplotype reconstruction we showed that the mutation c.298G > T is probably a founder mutation.
By using Illumina cDNA microarrays and quantitative PCR we detected a distinct age-dependent response to stroke involving @number@ differentially expressed genes.
By using Logistic regression , paternal age was divided into five categories , and maternal age into four categories.
By using microarray technology , a more complete description of the blood proteome of IBD patients is feasible.
By using nerve growth factor-exposed PC12 cells , we determined that Egr-1 activates Cdk5 to promote phosphorylation of tau and inactivates PP1 via phosphorylation.
By using the information , the iMec could evaluate the adequacy about how to take medicines.
By using the National Health & Aging Trends Study data set , the researchers explored the characteristics to describe this population.
By using these models , the estimate of TDEE for nutritional maintenance was ±500 kcal / d across the spectrum of ALS progression.
By virtue of high receptor density in the circadian pacemaker , melatonin is involved in the phasing of circadian rhythms and sleep promotion.
By virtue of medical advances and an aging society , people have increased opportunities for healthcare exposure.
By virtue of these multiple actions the naturally occurring A2M has strong potential as a novel therapeutic agent.
By visual assessment , the sensitivity and specificity were @percent@ and @percent@ , respectively.
By week @number@ signi cant reduction in coarse wrinkles was evident.
By Western blot , using antibodies specific to three-repeat Tau , Line @number@ expressed 5-times more Tau than Line @number@
By what strategies can we achieve the strongest and most complete rehabilitative corrections ?
By wheel running assessment , the POMC animals ran twice the distance as the Control or pair-fed rats.
By year @number@ persons in ILI with preexisting cardiovascular disease were no different in PF than in DSE participants with preexisting cardiovascular disease.
BZA was generally safe and well tolerated in these studies.
BZDs are commonly prescribed for symptoms of anxiety and / or insomnia despite their documented side effects over time.
C1q and C3 mRNA showed a substantial additional elevation during amyloid formation in APP23 mice.
C1q-deficient mice exhibited enhanced synaptic plasticity in the adult and reorganization of the circuitry in the aging hippocampal dentate gyrus.
C21 was devoid of cytotoxic effects in proliferating SK-UT-1 cells and in quiescent HutSMC.
C2C12 myoblasts were used as model to assess the impact of lymphocyte conditioned media ( CM ) following anti-CD3 / IL-2 activation.
C-33A is one of the rare cervical cancer derived cell lines considered as HPV-negative.
C5b-9 was increased by CSE , but at sublytic levels , only after addition of normal human serum.
C6 glioma cells stably depleted of Spp1 displayed reduced sphere forming capacity and downregulated stemness marker expression.
C7 plumbline in front of the HA is not necessarily associated with a spinal pathology.
C7 plumbline was behind the HA in @percent@ of subjects.
C9orf72 patients had enhanced visual network functional connectivity versus sporadic-motor and sporadic-early cases.
C9orf72 patients showed cerebellar and thalamic atrophy versus all sporadic cases.
C9orf72 repeat expansions are a frequent cause of ALS in Belgium , and also in sALS patients.
CA 19-9 levels ( normal range , 0-35 U / mL ) were measured in all participants.
Ca ( 2 + ) influx into neurons occurs through plasma membrane receptors and voltage-dependent ion channels.
CAA-associated vasculopathies , such as microaneurysmal formation with fibrinoid necrosis , underlie such cerebrovascular events.
CA also ameliorated HCl / EtOH-induced gastric symptoms via the suppression of JNK , IRAK1 , and IRAK4.
CAA-related disorders include hemorrhagic and ischemic stroke and dementia.
CAA-related hemorrhages include intracerebral lobar macrohemorrhages , cortical microhemorrhages , and focal subarachnoidal hemorrhages / superficial siderosis.
CAA tended to co-occur with Alzheimer's disease neuropathologic changes but a minority of cases were discrepant.
CABG added to MED has a consistent beneficial effect on cardiovascular mortality regardless of age.
CAC and AAC were measured with non-contrast computed tomography.
CAC and AAC were quantified using modified Agatston scores ( AS ) .
CAC and EFV showed a significant correlation ( ρ = @number@ P < @number@ ) .
CAC did not differ according to ucMGP quartile ( P = @number@ age-adjusted ) .
Cachexia is defined as a multifactorial syndrome that is associated with anorexia , weight loss and increased catabolism , with increased morbidity and mortality.
CA crosses the blood-brain barrier to up-regulate endogenous antioxidant enzymes via activation of the Nrf2 transcriptional pathway.
CAC was present in @number@ of @number@ participants ( @percent@ ) with a median CAC score of @number@ ( interquartile range , @number@.3-145.8 ) .
Cadaveric studies permit more precise measurement of HSA parameters and allow further analyses by micromorphometric methods.
Cadaveric studies were specifically sought for anatomic review , and comparison group outcome studies are preferentially cited over clinical case series.
Cadavers were of Caucasian ethnicity , well preserved , belonging to individuals who died of natural death.
Cadavers were without previously diagnosed kidney disease , diabetes , hypertension , or any other systemic disease.
Cadazolid , a novel antibiotic , exhibits potent in vitro activity against Clostridium difficile , including the epidemic BI / NAP1 / 027 strain.
Cadazolid was well tolerated , with no safety signal observed.
CaDeN proposes a unique model that might be applied both in national settings and for different transformational challenges in health care.
CaDeN will deploy multiple levels of action across multiple stakeholder groups simultaneously in an ecological approach to health system change.
CAD is probably underdiagnosed in this population due to a higher prevalence of more common causes of stroke at this age.
CAD may be also associated to increased AA diameter.
CAD may develop secondary to thoracic irradiation , dyslipidemia caused by hormonal treatment or simply as results of endothelial dysfunction caused by alkylating agents.
Cadmium concentrations in blood , but not in urine , were associated with slower gait speed.
Cadmium levels were significantly different between 6-7 year old girls , @number@ year old boys and 10-11 year old girls.
CA dose-dependently inhibited the viability of HCT116 cells.
Caenorhabditis elegans contains a single SUMO ortholog , SMO-1 , necessary for the reproduction of C. elegans.
Caenorhabditis elegans LROs are the site of concentration of vital dyes such as Nile red as well as age-associated autofluorescence.
Caffeic acid ( CA ) is a phenolic compound that is frequently present in fruits , grains , and dietary supplements.
Caffeine , an antagonist of adenosine receptors , has been used as a tool in some of the studies reviewed in the present chapter.
Caffeine given at breakfast significantly stimulated ketone production in a dose-dependent manner ( @percent@ ; @percent@ ) and also raised plasma free fatty acids.
Caffeine has been reported to produce many beneficial effects for health.
Caffeine intake was determined according to self-reported coffee , tea , and cola consumption at baseline.
Caffeine is a methylated-derivate of xanthine with profound effects on the onset and quality of sleep episodes.
Caffeine is a widely consumed psychoactive drug , which is emerging as a protective agent against AD progression and in aging associated deficits.
CA formation is enhanced in the MCI hippocampus and thus occurs relatively early in the pathogenesis of AD.
CAGn did not correlate significantly with testosterone in the three samples.
CaHA hyperdilution takes advantage of its skin-tightening properties without a volumizing effect.
CaHA is classified as an adjustable filler , whereas HA is fully reversible by hyaluronidase digestion.
CA is very sensitive to changes in pCO₂.
Calcein acetyoxymethyl ester ( calcein AM ; @number@ μM ) was added for @number@ min as the reporting molecule.
Calcific aortic stenosis remains a major cause of mortality and morbidity in the aging population.
Calcific aortic valve disease ( CAVD ) is a highly prevalent cardiovascular disorder accounting for a rising economic and social burden on aging populations.
Calcific aortic valve stenosis ( CAVS ) is a major health problem facing aging societies.
Calcification and ossification of joints were induced with age from fibrous tissue and cartilage on the outer margin of a joint.
Calcification could affect extracellular matrix along with VSMCs.
Calcification nuclei were not found and there were only a few remains of internuclear spaces.
Calcification of cartilage causes unexpected absorption , difficult manipulation , and donor site morbidity.
Calcification of the coronary and carotid artery and the aorta was assessed by multi-detector computed tomography.
Calcification of the sixth and seventh rib cartilage significantly increased with age.
Calcification of the vascular smooth muscle cell ( VSMC ) layer of the vessel media is a hallmark of vascular ageing.
Calcifications ( vascular wall and parenchymal ) occur in the normal aging brain and in neurodegeneration ; some associated genes are already described.
Calcifications were more prominent at the posterior portion of the cartilage in both genders and increased with age.
Calcific or a degenerative process is the most common cause of this pathological process and increases with aging population.
Calcineurin inhibitors compared to rapamycin have a more pronounced prosenescence effect.
Calcitonin gene-related peptide ( CGRP ) , a major neurotransmitter of the capsaicin-sensitive sensory nerves , protects endothelial function.
Calcitonin receptors ( CTR ) are involved in maintaining calcium homeostasis.
Calcitriol , alone or in combination with other agents , should be considered for the therapy of osteoporosis.
Calcitriol ( CTR ) administration prevented a decrease in renal Klotho expression.
Calcitriol in combination with other therapeutic bone agents was shown to have additional bone-preserving effects when compared to the use of therapeutic bone agents alone.
Calcitriol is mainly effective by stimulation of the Vitamin D receptor VDR.
Calcitriol , the active form of vitamin D , regulates intestinal calcium absorption , among other actions.
Calcium absorption was not correlated with serum PTH and serum 25OHD , and no threshold was found.
Calcium also plays a role in preventing bone loss and osteoporotic fractures in later life.
Calcium and vitamin D supplements were taken by @percent@ and @percent@ of the total population , respectively.
Calcium ( Ca ( 2 + ) ) is an universal second messenger that regulates the most important activities of all eukaryotic cells.
Calcium ( Ca ) , inorganic phosphate ( Pi ) , vitamin D , and protein are nutrients that impact bone and skeletal muscle integrity.
Calcium channel blockers have been shown to be effective in this condition in the elderly.
Calcium channels control the inflow of calcium ions into cells and are involved in diverse cellular functions.
Calcium hydroxylapatite-induced skin necrosis occurred in @number@ patients after injection in the glabella and the nasolabial fold , respectively.
Calcium imaging was used to monitor intracellular calcium changes.
Calcium-independent iPLA ( @number@ ) -VIA and cytosolic PGE ( @number@ ) synthase were decreased.
Calcium influx increased 9-fold after treatment with CTAB liposomes.
Calcium intake should be encouraged , preferably through diet.
Calcium intake should be optimized ( 1200-1500 mg per day recommended ) and supplementation offered to those with inadequate intake.
Calcium ion is a highly versatile cellular messenger.
Calcium , iron and zinc were identified as \ "problem nutrients \ " as persistently reported in developing countries.
Calcium is necessary for insulin secretion , suggesting vitamin D may contribute to maintaining insulin secretion.
Calcium nodules of young adult donors ' specimens were significantly more numerous and larger than those from elderly donors.
Calcium-permeable and thermosensitive transient receptor potential ( TRP ) channels mediate the nociceptive transduction of noxious temperature in Drosophila nociceptors.
Calcium scores were analyzed separately for sexes.
Calcium score was similar in the two groups.
Calculated effect sizes were @number@ for anxiety , @number@ for depression and between @number@ and @number@ for satisfaction with different domains of daily life.
Calculated RI values for MLBs ranged from @number@ to @number@
Calculating pregnancy losses per positive pregnancy showed a strong correlation with increasing female age.
Calculation of photodemethylation intensities from Hg or MMHg MIF , therefore , requires a baseline correction.
Calculation of the leg kinematics and kinetics was done by means of a rigid , three-segment , 3D leg model.
Calculations based on a reference population indicate advancement of reproductive age of approximately @number@ years.
CaLD participants also reported prejudicial treatment from non-CaLD staff.
Calf circumference was also greater in physical activity group.
Calf hypertrophy and selective fatty replacement of the adductor magnus and gastrocnemius muscles were prominent clinical and muscle imaging features.
Calf muscle composition assessed by quantitative computed tomography.
Calf venous compliance was ∼30% lower ( P < @number@ ) in older compared with young men before adrenergic blockade.
Calibration can take more time when the perceptual-motor information that is available is less relevant.
CALM functions to regulate vesicle sizes , and this study shows that CALM is not recruited to the TGN in the absence of SMAP2.
CALM is thus a major factor in controlling CCV size and maturation and hence in determining the rates of endocytic cargo uptake.
Caloric and protein intake were estimated on the basis of three nonconsecutive 24-hour diet recalls and appendicular skeletal muscle mass by dual-energy X-ray absorptiometry.
Caloric expenditure was calculated using volume of oxygen consumption and carbon dioxide production.
Caloric intake influences metabolic homeostasis , somatic maintenance , tissue regeneration , and longevity in metazoans.
Caloric restriction could prevent the progression of atherosclerosis and vascular aging through direct and indirect mechanisms.
Caloric restriction ( CR ) and antioxidants have been proposed as strategies to attenuate age-related brain changes.
Caloric restriction ( CR ) can also play a crucial role in aging and cancer.
Caloric restriction ( CR ) has been extensively documented for its profound role in effectively extending maximum lifespan in many different species.
Caloric restriction ( CR ) has similar effects on healthspan and lifespan , and causes an extension of longevity in Ames dwarf mice.
Caloric restriction ( CR ) increases maximum lifespan but the mechanisms are unclear.
Caloric restriction ( CR ) is widely used to study aging processes.
Caloric restriction decreases the expression of most of inflammatory markers.
Caloric restriction has consistently been shown to extend life span and ameliorate aging-related diseases.
Caloric restriction is an established intervention , of which anti-aging effects are scientifically proven.
Caloric restriction is known to retard ageing and delay functional decline as well as the onset of disease in most organisms.
Caloric restriction is the most powerful anti-aging strategy conserved throughout evolution in the animal kingdom.
Caloric restriction prevents diseases of aging , including AD , in animal models , perhaps by activation of sirtuins.
Calorie consumption was below the recommended intakes for elderly nursing home residents in France , whatever the type of texture.
Calorie or dietary restriction ( CR ) has attracted attention because it is the oldest and most robust way to extend rodent life span.
Calorie restriction ( CR , decreasing caloric intake by 30-40% ) could extend longevity and reduce aging-related diseases.
Calorie restriction ( CR ) , intermittent fasting , and protein and amino acid restriction prolong the lifespan of mammals by IGF-1 regulation.
Calorie restriction ( CR ) is defined as a reduction in calorie intake below the usual ad libitum intake without malnutrition.
Calorie restriction ( CR ) is the most effective nutritional intervention for slowing aging and preventing chronic disease in rodents.
Calorie restriction ( CR ) reduces bone quantity but not bone quality in rodents.
Calorie restriction ( CR ) remains the most robust environmental intervention for altering aging processes and increasing healthspan and lifespan.
Calorie restriction ( CR ) slows aging and is thought to improve insulin sensitivity in laboratory animals.
Calorie restriction ( CR ) without malnutrition is the most robust intervention to slow aging and extend healthy lifespan in experimental model organisms.
Calorie Restriction ( CR ) without malnutrition slows aging and increases average and maximal lifespan in simple model organisms and rodents.
Calorie restriction prevents biotin accumulation , abolishes abnormal histone biotinylation , and completely restores the metabolic and adipose functions of Adipo-H363Y.
Calorie restriction significantly reduced the level of ROS in the stationary phase and extended the CLS of nth1Δ rad16Δ cells.
Calphostin C and LY blunted hyperosmolarity-induced VCAM-1 expression , while increasing the expression of Ser1146-eNOS and nitrite production.
Calyceal dilatation was more likely in those developing UTI ( P = 0.02 ) .
Cambridge : Cambridge University Press ) .
CAMP is a zinc-finger protein containing three characteristic repeat motifs termed the WK , SPE , and FPE motifs.
CAMP localizes to chromosomes and the spindle including kinetochores , and undergoes CDK1-dependent phosphorylation at multiple sites during mitosis.
CAMs expression persists in the adult brain particularly in structures undergoing postnatal neurogenesis and involved in synaptic plasticity and memory as the hippocampus.
CAM use has grown and become popular among patients.
Canada and other countries are changing the age for public pension eligibility.
Canada's aging population poses a significant challenge for the existing healthcare system.
Canada's health and its care are evolving.
Canada's health and social care system is paralyzed by our decentralized federalist governing structure.
Canada's nursing homes have become increasingly dependent on immigrant health care aides.
Canada's old age security ( OAS ) , a flat-benefit public pension , is internationally lauded as an accessible and effective safety net for seniors.
Canada's population is aging , and seniors constitute the fastest growing demographic in the nation.
Canadians ' health and its care continue to evolve.
Can age-indexed variations in the fractal dimension of the works of artists anticipate specific cognitive deteriorations ?
Canaloplasty could provide better localization benefit and subjective improvement in spatial sensation to unilateral CAA patients.
Canals were noticeably simpler in older adults : they were sharply defined and narrow , sometimes too narrow.
Cancer and ageing are often said to be diseases of development.
Cancer and aging are characterized by a similar dysregulated metabolism consisting in upregulation of glycolysis and downmodulation of oxidative phosphorylation.
Cancer and aging may conspire in making anemia more frequent and more severe.
Cancer and cardiovascular disease are @number@ major disease of the Japanese cause of death.
Cancer cells are optimised for growth and survival via an ability to outcompete normal cells in their microenvironment.
Cancer cells might accumulate unhealthy mitochondria due to p53 mutations and / or Mieap methylation , representing a potential cause of the Warburg effect.
Cancer cells prefer aerobic glycolysis , but little is known about the underlying mechanism.
Cancer chemoprevention is defined to prevent or delay the development of cancer by the use of natural or synthetic substances.
Cancer commonly occurs in elderly patients.
Cancer commonly occurs in the elderly and immunotherapy ( IT ) is being increasingly applied to this population.
Cancer constitutes an enormous burden on society in more and less economically developed countries alike.
Cancer diagnoses had been registered in the follow-up period in @number@ ( @percent@ ) HHT patients and in @number@ ( @percent@ ) controls.
Cancer diagnosis and treatment exposure were abstracted from medical records.
Cancer diagnosis and treatment may influence dietary intake.
Cancer Discov ; 7 ( @number@ ) ; 165-76. ©2016 AACR.This article is highlighted in the In This Issue feature , p. @number@
Cancer disorders exhibit an increasing high global incidence , in part , to an aging population with a high socio-economic burden.
Cancer Epidemiol Biomarkers Prev ; 24 ( @number@ ) ; 490-7. ©2014 AACR.
Cancer Epidemiol Biomarkers Prev ; 25 ( @number@ ) ; 1483-90. ©2016 AACR.
Cancer Epidemiol Biomarkers Prev ; 25 ( @number@ ) ; @date@ . ©2016 AACR.
Cancer Epidemiol Biomarkers Prev ; 26 ( @number@ ) ; 136-44. ©2016 AACR.
Cancer genesis across the age spectrum is a complex , multifactorial process , and parallels changes in site-specific tissue development , maintenance , and senescence.
Cancer has been the most common cause of death in Korea since @number@ and is a major public health concern.
Cancer health disparities are persistent reminders that state-of-the-art cancer prevention , diagnosis , and treatment are not equally effective for and accessible to all Americans.
Cancer incidence increases with advancing age.
Cancer incidence over the four subsequent years was identified through linkage with Medicare claims data.
Cancer incidence was calculated by dividing mortality estimates through the modeled MI ratios.
Cancer in elderly patients is an increasingly common problem.
Cancer information obtained through feasible methods is therefore becoming the basis for planning effective cancer control programs.
Cancer in the geriatric population is a growing problem.
Cancer is a major chronic disease threatening the people's health in China.
Cancer is a major health problem that is widespread in elderly people.
Cancer is an age-related disease , whose risk has been proven to increase with age.
Cancer is anticipated to exceed cardiovascular disease as the primary cause of mortality in the United States population.
Cancer is controlled not only by genetic events but also by epigenetic events.
Cancer is initiated when a cell gains a fitness sufficiently high to escape from the homeostatic mechanisms of the cell compartment.
Cancer is not a single disease , and different tumor and stem cells may demonstrate various manifestations of abnormal function.
Cancer mortality continues to increase after age 85 + .
Cancer @number@ ; 123 : 2551-60. © @number@ American Cancer Society.
Cancer @number@ ; 123 : 4207-4214. © @number@ American Cancer Society.
Cancer occurs frequently in association of one or more other chronic diseases , that affect the efficacy of various treatment interventions.
Cancerous and stromal tissues were separately collected by laser-captured microdissection.
Cancer prevalance and incidence is increasing with aging of populations and age is a critical factor in decision-making for anti-cancer treatment.
Cancer prevention strategies should focus on these cancers after endometrial cancer diagnosis.
Cancer Prev Res ; 9 ( @number@ ) ; 875-86. ©2016 AACR.
Cancer progression is linked to loss of the prodeath function of BNIP3 , but also to induction of its prosurvival activity.
Cancer-promoting conditions , such as inflammation , can induce persistent oxidative stress and increased LPO , resulting in the accumulation of ε-adducts in different tissues.
Cancer recurrence , vital status and cause of death were documented over a median follow-up time of @number@ years.
Cancer registration in Japan has a long history spanning over @number@ years ; the first population-based cancer registry was established in Miyagi prefecture in @number@
Cancer-related pain is a major hindrance to the maintenance of functional independence and fatigue is harbinger of disability and death.
Cancer Res ; 76 ( @number@ ) ; 6382-95. ©2016 AACR.
Cancer resistance is a major cause for longevity of the naked mole-rat.
Cancer results from multistep pathogenesis , yet the pre-malignant states that precede the development of many hematologic malignancies have been difficult to identify.
Cancers contain newly formed immature vessels devoid of firm coverage by pericytes.
Cancer screening and treatment programs have been developed for colon cancer , breast cancer and prostate cancer.
Cancer screening depends on life expectancy.
Cancer site and extension were not significantly associated with early death.
Cancers of the rectum presented at a relatively earlier age.
Cancer spreads in the anterior commissure along the fibers anchoring voice muscle within the Broyles ligament and is seen in tumor cells microembolism.
Cancer survival analysis is an essential indicator for early detection and improvement in cancer treatment.
Cancer survivors are at risk for a wide range of late effects after their primary cancer treatment.
Cancer survivorship was an ambiguous concept that predated the women's cancer experience.
Cancer survivors with irregular menstrual function were found to have lower quality-of-life ( QOL ) scores than those with regular cycles.
Cancer treatment and health behaviors influence the magnitude of differences by age groups.
Cancer treatment summaries and survivorship care plans are an initial attempt to address the current fragmentation and lack of coordination in care that exist today.
Cancer vaccine feasibility would benefit from reducing the number and duration of vaccinations without diminishing efficacy.
Cancer was relatively rare , but added significantly to cost.
Can cognitive abilities such as reasoning be improved through working memory training ?
CAND1 knockdown by small interfering RNA promoted the proliferation of LNCaP cells.
Candida endocarditis should be treated immediately , including surgical treatment in combination with liposomal amphotericin B or caspofungin with optional addition of flucytosine.
Candidate gene studies have identified variants at APOE and FOXO3A associated with longevity ; other genes show inconsistent results.
Candidate indicators were submitted with CA to correlation and redundancy analyses.
Candidate loci were then evaluated for SMCHD1 binding using ChIP-qPCR and expression was evaluated using RT-qPCR.
Candidate participants are eligible for enrolment if they are at least @number@ years of age and provide written informed consent.
Candidate predictor variables were those of published models that could be obtained from interview or medical record data.
Candidate risk factors included demographic characteristics , measures of social engagement , self-reported health conditions , ability to perform daily activities , and physical activity.
Candidate single-nucleotide polymorphisms were identified through review of the literature.
Canes and walkers are commonly characterized as assistive devices that serve the same purpose : as walking aides.
Canine data were compared with human IVD data acquired in this study or from the literature.
Cannabinoid CB2 PET tracers are considered as a promising alternative to PBR / TSPO tracers for the in-vivo imaging of neuroinflammation.
Cannabinoid receptors , CB1 and CB2 , are therapeutic targets in the treatment of anxiety , obesity , movement disorders , glaucoma , and pain.
Cannabinoid receptors ( CBR ) , including CB1 and CB2 have been therapeutic targets for a number of conditions.
Cannabis use is associated with an acceleration of the cardiovascular age , which is a powerful surrogate for the organismal-biological age.
Canonical NHEJ requires DNA-PKcs and Ku70 / 80 , while alternative NHEJ pathways are DNA-PKcs and Ku70 / 80 independent.
Can our insights and research be translated into improved clinical practice ?
CANTAB allows cognitive assessment across cultures and education levels with reduced interference of the examiner during data acquisition.
CANTAB tests included : Visual Sustained Attention , Reaction Time , Spatial Working Memory , Learning and Episodic Memory.
Can these approaches be employed interchangeably ?
Can these cells be therapeutically eliminated ?
Can the willingness to postpone future gratification differentiate between individuals prone to serious , premeditated and less serious , unplanned suicidal acts ?
Can we expect to get closer to that theoretical asymptote of @number@ years of human life ?
Can we identify more aggressive tumors by computationally analyzing the morphological heterogeneity of the tumor tissues ?
Can we intervene correcting this dysregulation ?
Canyon borders are demarked by 5-hydroxymethylcytosine and become eroded in the absence of DNA methyltransferase 3a ( Dnmt3a ) .
Canyons mostly form between LADs and are enriched in genes and enhancers.
CAP1 is ubiquitously expressed whereas CAP2 shows restricted tissue distribution.
CAP2 is expressed in skin.
Capacities are infrequently presented and are unrealistic in several of the movies.
Capacities of the prefrontal cortex ( PFC ) such as working memory ( WM ) are known to decline with increasing age.
Capacity evaluations must integrate multiple sources of data and focus on functional abilities.
CAPE ACFI funding varied from $ @time@ grade A to $ 127.50 for grade E4.
CAPER is also a coactivator for NF-κB that directly regulates c-Myc to coordinate nuclear transcriptome responses to mitochondrial stress.
CAPE treatment also inhibited soft agar colony formation and retarded nude mice xenograft growth of LNCaP 104-R1 cells.
CAPE treatment decreased Skp2 and Akt1 protein expression in LNCaP 104-R1 tumors as compared to control group.
Capillary density , capillary fiber contacts and femoral artery Doppler were similar between MA and YG.
CAP incidence increased more markedly with age , from @number@ to @number@ episodes / 1000 person-years respectively , and was higher among men.
Capitalizing on the Essential Tremor Centralized Brain Repository , we quantified Purkinje cell linear density in cases versus controls.
Capsaicin induced oxidative stress , but was ineffective in provoking the dissipation of the mitochondrial inner transmembrane potential.
Capsaicin is the major pungent component of the hot chili peppers of the genus Capsicum , which are consumed worldwide as a food additive.
Capsaicin was also found to be a DNA hypermethylating agent in A549 cells.
Capsaicin was found to induce apoptosis and inhibit proliferation of a wide range of cancer cells in vitro , whereas being inactive against normal cells.
Capsaicin was unable to provoke apoptotic cell death when used up to @number@ μM concentrations.
Carbamylation has been linked with renal fibrosis , atherosclerosis and anaemia.
Carbamylation is a non-enzymatic post-translational modification that physiologically occurs during aging and is a risk factor for various diseases.
Carbamylation triggers structural and functional modifications of proteins , thus impairing their biological roles and their interactions with cells.
Carbocysteine , an anti-oxidant and mucolytic agent , is effective in reducing the severity and the rate of exacerbations in COPD patients.
Carbohydrate , protein and lipid intakes were determined based on a non-consecutive three-day dietary record.
Carbohydrates are essential nutrients that are used as a primary source of energy.
Carbon reduction at the household level is an integral part of carbon mitigation.
Carbonylated albumin displayed biological effects that may be relevant to uremic atherosclerosis.
Carbonylation due to oxidation and glycation is an important biochemical cause of degenerative diseases and aging.
Carbonyl protein was determined by the method described in Levine et al.
Carbonyl stress is implicated in conditions and diseases like aging , diabetes mellitus , Alzheimer's disease and cardiovascular diseases.
Carboxymethyl-lysine ( CML ) , a ubiquitous human advanced glycation endproduct , has been associated with age-related conditions and mortality.
Carcinogenesis is associated with a progressive reduction in the ability of the cells to trigger apoptosis and senescence.
Carcinogenesis was driven by testosterone plus E2 treatment for @number@ to @number@ months to model rising E2 levels in aging men.
Carcinomas were reduced by @percent@ ( P < @number@ ) .
Cardiac aging is an intrinsic process that results in impaired cardiac function , along with cellular and molecular changes.
Cardiac aging was associated with strong VEGF / VEGF-R2 pathway downregulation.
Cardiac and peripheral functions contribute equally to exercise intolerance in HFpEF , though the latter has been the focus of fewer studies.
Cardiac and peripheral vasomotor factors contribute to the rapid pressor response at the onset of isometric handgrip exercise.
Cardiac arrhythmias are cardiac rhythm disorders that comprise an important epidemiological and public health problem.
Cardiac AT1aR , Bax , and IGF-1 mRNA expression was significantly increased by DEX compared to SAL at E17.5.
Cardiac autonomic dysfunction is a serious condition in the elder subjects.
Cardiac autonomic parameters were analyzed by Wilcoxon and Mann-Whitney tests.
Cardiac damage is a major contributor to the morbidity and mortality particularly associated with coronary artery disease.
Cardiac death is the leading cause of death ; however , death due to stroke and acute myocardial infarction is decreasing.
Cardiac death occurred in @number@ patients in the PCI group and in @number@ patients in the non-PCI group.
Cardiac disease was defined as a history of atrial fibrillation , ischemic heart diseases , or congestive heart failure.
Cardiac dysfunction and cognitive impairment are both common in older adults.
Cardiac failure is a leading cause of age-related death , though its root cause remains unknown.
Cardiac failure is dictated by an uncompensated reduction in the number of viable and fully functional cardiomyocytes.
Cardiac failure is the most prevalent cause of death at higher age , and is commonly associated with impaired energy homeostasis in the heart.
Cardiac fibrogenesis is a common pathophysiological process seen during chronic and stress-induced accelerated cardiac aging.
Cardiac fibrosis may contribute to cardiac dysfunction , exercise intolerance , and congestion in HFpEF.
Cardiac function and dysfunction exhibit striking time-of-day-dependent oscillations.
Cardiac function ( echo ) and left ventricular ( LV ) filling pressures ( right heart catheterization ) were measured under varying preloads.
Cardiac function is required for blood circulation and systemic oxygen delivery.
Cardiac hypertrophy is a multifactorial disease characterized by multiple molecular alterations.
Cardiac imaging plays a central role in selecting patients , guiding the procedure and evaluating the durability of the repair at follow-up.
Cardiac index ( liters per minute per meter squared ) was quantified from echocardiography.
Cardiac magnetic resonance imaging was used for assessment of cardiac volumes.
Cardiac norepinephrine depletion is as severe as the loss of putamen dopamine.
Cardiac organ damage was evaluated by echocardiography.
Cardiac output ( inert-gas rebreathing ) was recorded at rest and @number@ and @number@ s during two additional bouts.
Cardiac output was estimated from pulse contour analysis and was corrected for body size ( cardiac index ) .
Cardiac remodeling in patients with HCM is higher in men than in women , the same is seen in HCM animal models.
Cardiac response to exercise differed slightly in the older subjects compared to younger ones.
Cardiac resynchronization therapy ( CRT ) , but not Type D personality , was associated with increased mortality in older patients.
Cardiac resynchronization therapy , particularly biventricular pacing , offers promise , but requires careful study before widespread implementation.
Cardiac-specific Bmi1 deletion induces the development of DCM , which progresses to lung congestion and heart failure.
Cardiac-specific expression of disease causing Poly-Q also shortens lifespan of flies dramatically.
Cardiac-specific knockdown of scox reduces fly lifespan , and it severely compromises heart function and structure , producing dilated cardiomyopathy.
Cardiac structural remodeling occurs in concert with electrophysiologic remodeling , both of which contribute to atrial and ventricular rhythm disturbances , including AF.
Cardiac structure , left ventricular diastolic function and left ventricular systolic function were measured using a Doppler ultrasound scanner and compared between the two groups.
Cardiac surgery involving cardiopulmonary bypass imposes a significant pathophysiologic burden on patients.
Cardiac troponin T ( TnT ) , a marker of cardiomyocyte injury , can be detected by high-sensitivity TnT ( hsTnT ) assay.
Cardiac vagal control was measured as high-frequency heart rate variability.
Cardioembolic stroke and small vessel disease were found to be positively associated with aging and living in Beirut , respectively.
Cardiolipin abnormalities have been associated with mitochondrial dysfunction in a variety of pathological conditions and aging.
Cardiolipin alterations are associated with mitochondrial bienergetics decline in multiple tissues in a variety of physiopathological conditions , as well as in the aging process.
Cardiolipin ( CL ) , a mitochondria-specific glycerophospholipid , is required for diverse mitochondrial processes and orchestrates the function of various death-inducing proteins during apoptosis.
Cardiolipin plays a central role in several mitochondrial bioenergetic processes as well as in mitochondrial-dependent steps in apoptosis and mitochondrial membrane stability and dynamics.
Cardiologists often use combination therapies including serotoninergic agents , and should therefore consider the risk of serotoninergic adverse events caused by inappropriate drug interactions.
Cardiology , internal medicine , geriatric and oncology syndromes are dominating manifestations in HIV positive patients on antiretrovirals.
Cardiometabolic diseases were ascertained at baseline.
Cardiometabolic markers included hemoglobin A1c and systolic BP.
Cardiometabolic risk factors were defined following the most commonly used criteria.
Cardiomyocyte hypertrophy is an adaptive response of the heart to various types of stress.
Cardiomyopathies are a heterogeneous group of diseases of the myocardium.
Cardiomyopathy is the leading cause of heart failure.
Cardiopulmonary complications occurred in @number@ ( @percent@ ) patients , including four ( @percent@ ) deaths.
Cardiopulmonary interactions apparent with common complex heart and lung diseases evolve concurrently from early adulthood forward.
Cardiorespiratory fitness ( CRF ) is one individual difference factor that may attenuate brain aging , and thereby contribute to enhanced source memory in OA.
Cardio-respiratory fitness was associated with volume of overall physical activity as well as lying , sitting , standing , walking and stair climbing.
Cardiorespiratory fitness was found to be a stronger predictor of number of chronic conditions and BMI than total physical activity and sedentary.
Cardiorespiratory responses , prefrontal cortex and quadriceps tissue oxygenation ( near-infrared spectroscopy ) were measured during exercise as well as during hypercapnia at rest.
Cardiotoxicity , also referred to as cancer treatment-related cardiac dysfunction , has become an important cause of morbidity and mortality in cancer patients.
Cardiotoxicity induced by chemotherapeutic agents and radiotherapy is a growing problem.
Cardiovascular aging and disease are characterized by heart failure , cardiac ischemia-reperfusion injury , cardiomyopathy , hypertension , arterial stiffness , and atherosclerosis.
Cardiovascular and pulmonary conditions are common among persons with HIV infection.
Cardiovascular death may be the leading , but not the only , cause of death for contemporary severe AS patients.
Cardiovascular deaths accounted for a greater proportion of deaths in the youngest versus oldest quartile ( @percent@ versus @percent@ ) .
Cardiovascular disease and cancer were the most frequent causes of death in this aging cohort.
Cardiovascular disease , cancer , and death were confirmed by medical records or the National Death Index.
Cardiovascular disease ( CVD ) , both clinical and subclinical , has been proposed as one of the mechanisms underlying frailty.
Cardiovascular disease ( CVD ) is a health problem of great concern to both the public and medical authorities.
Cardiovascular disease ( CVD ) is a major public health issue in indigenous populations in the Arctic.
Cardiovascular disease ( CVD ) is the leading cause of death and disability worldwide.
Cardiovascular disease ( CVD ) is the leading cause of death for American women.
Cardiovascular disease ( CVD ) is the leading cause of death in the United States and aging is a major risk factor for CVD development.
Cardiovascular disease ( CVD ) is the leading cause of morbidity and mortality , affecting both developed and developing countries.
Cardiovascular disease ( CVD ) is the main cause of death and is associated with various risk factors including risk of undernutrition.
Cardiovascular disease ( CVD ) presents a great burden for elderly patients , their caregivers , and health systems.
Cardiovascular disease diminished the mean cognitive score also among discordant twin pairs ( β-estimate = 1.10 , p-value = @number@ ) .
Cardiovascular disease increases incrementally with age and elderly patients concomitantly sustain multimorbidities , with resultant prescription of multiple medications.
Cardiovascular disease is now a leading cause of morbidity and mortality in the HIV population as in the general population.
Cardiovascular disease is the leading cause of death among women.
Cardiovascular disease is the leading cause of morbidity and mortality in postmenopausal women.
Cardiovascular disease is the main cause of death globally , accounting for over @number@ million deaths each year.
Cardiovascular disease is the most prevalent and influential comorbidity affecting outcomes in geriatric surgical patients.
Cardiovascular disease remains a major medical and socioeconomic burden in developed and developing societies , and will increase with an aging and increasingly sedentary society.
Cardiovascular disease risk factors may be important correlates of age-related auditory dysfunction.
Cardiovascular diseases , and in particular left ventricular dysfunction and heart failure , are among the most significant of these.
Cardiovascular diseases are one of the most common causes of mortality and morbidity among elderly subjects worldwide.
Cardiovascular diseases are the most common cause of death among the elderly in the Western world.
Cardiovascular diseases ( CVD ) account annually for almost one third of all deaths worldwide.
Cardiovascular diseases ( CVD ) are major contributors to mortality and morbidity in South Asia.
Cardiovascular diseases ( CVD ) are the most important causes of morbidity and mortality in the developed and developing world.
Cardiovascular diseases ( CVDs ) are one of the major causes of mortality and disability in Western countries.
Cardiovascular diseases ( CVDs ) remain the leading cause of death in the United States and other modern societies.
Cardiovascular diseases , diabetes , dermatological , and orthopedic problems were common physical complaints in older people with PWS.
Cardiovascular diseases have become a major cause of morbidity and mortality and are likely to only increase as the geriatric population continues to grow.
Cardiovascular diseases have become increasingly common in the growing , ageing cohort of PWH.
Cardiovascular diseases were found among @percent@ of respondents , whereas pulmonary diseases with chronic coughing were present in @percent@ of the analyzed population.
Cardiovascular diseases were the most common.
Cardiovascular disorders are a common cause of falls and syncope in older adults.
Cardiovascular events can be reduced by managing risk factors , such as hypertension and increased lipids and body weight.
Cardiovascular mechanisms explain at least some of the variance in cognitive decline.
Cardiovascular medicines however may be underutilised in those with un-related co-morbidities.
Cardiovascular , metabolic , functional , cognitive , and QoL outcomes were targeted.
Cardiovascular protection with RAAS inhibitors varies ; different RAAS inhibitors offer different levels of protection.
Cardiovascular reflex tests mainly characterizing sympathetic function had no correlation with aortic stiffness parameters ( p = NS for all correlations ) .
Cardiovascular research needs to further explore age-related differences in psychosocial risk.
Cardiovascular risk and heart age was estimated by the Framingham Risk Score.
Cardiovascular Risk factors , Aging and Dementia ( CAIDE ) is a Finnish population-based study.
Cardiovascular risk factors and the ankle-brachial index ( ABI ) were also assessed.
Cardiovascular risk factors are also associated with AMD.
Cardiovascular risk factors had no association with VEMP parameters.
Cardiovascular risk factors , serum hormonal and metabolic mediators , and body composition were considered as potential confounders.
Cardiovascular risk factors were measured.
Cardiovascular risk is measured as hypertension , rapid heart rate , C-reactive protein , and general cardiovascular events.
Cardiovascular risk was based on the Cardiovascular Risk Prediction Model for populations in Asia.
Cardiovascular risk was calculated using the Lifetime Risk Score ( LRS ) .
Cardiovascular screening , prevention , and risk factor management are important factors in the management of patients infected with HIV worldwide.
Care arrangements for the elderly are becoming a main social process in contemporary societies due to socio-political and lifestyle changes over the last few decades.
Care coordinators from VAMCs and Alzheimer's Association chapters worked as a team using a shared computerized record.
Care for elders still relies on family , with lack of professionalism , little socialization , and expanding commodification.
Care for older people is a complex phenomenon , and is an area of pressing policy concern.
Care f or the elderly was rated fair in all five cases.
Careful analysis of the interfollicular epidermis showed aberrant expression of the lamin B receptor ( LBR ) in the suprabasal layer.
Careful analysis of the patient should be made to decide both the technique and the changes desired by the patient and the surgeon.
Careful and deliberate preoperative counseling of patients regarding the possible bumps in the road to recovery is critical.
Careful career mentoring by the supervisor as part of an aging policy can contribute to the maintenance of workers of any age.
Careful clinical correlation and appropriate investigations are essential to exclude secondary causes.
Careful consideration of fracture risk and the risk-benefit profile of antiosteoporosis medications is required when managing patients with osteoporosis.
Careful evaluation is critical for successful management.
Careful evaluation of longitudinal data will be needed to confirm whether this is a true effect of aging , or a cohort or survivor effect.
Careful evaluation of medications and underlying medical conditions is essential for the proper management of nocturia.
Careful monitoring of medication levels for prevention of rejection while avoiding over immunosuppression and infection is critical to ensure such benefit.
Careful patient selection is mandatory to reduce complications to a minimum.
Careful range selection for CT protocols is necessary for organ dose optimization for pediatric and adult patients.
Careful selection of patients and monitoring of treatment effects are required to optimize use of the antiangiogenic agent bevacizumab in older patients.
Caregiver burden did not mediate the relationship between obsessive-compulsive symptom severity and caregiver QoL.
Caregiver burden had an indirect effect on caregiver mental health that was partially mediated by finding meaning.
Caregiver burden is discussed in the context of changing demographics and the growing prevalence of disorders affecting older adults.
Caregiver burden was not associated with caregiver physical health.
Caregiver depression was predicted positively by caregiving burden , while burden was predicted negatively by filial piety.
Caregiver depressive symptoms predicted caregiver QoL , and caregiver depressive symptoms and child externalizing symptoms both predicted caregiver burden.
Caregiver distress mediated the association between delusions and agitation and institutionalization.
Caregiver distress was identified in @percent@ and @percent@ felt overwhelming burden.
Caregiver empathy , mood , sex or other demographic characteristics were not predictive of caregiver ratings.
Caregiver grief was measured by means of MM-CGI-50.
Caregiver leisure satisfaction was chronically lower than in noncaregivers.
Caregiver outcomes include health-related quality of life and depressive symptoms.
Caregiver provision of direct patient care activities was also associated with increased burden but improved relationships with patients.
Caregiver reported sociodemographic characteristics , caregiving intensity and tasks performed , health , and psychosocial effects.
Caregivers acquire and deepen competencies required to improve communication in dementia care.
Caregivers are exposed to a variety of stressors , which may lead to feeling burdened , or to depression and anxiety.
Caregivers are open to discussions of screening cessation that focus on quality of life , burdens , and benefits.
Caregivers associated ' hominess ' with freedom of movement , action and choice , with favorable social dynamics and with the building's residential character.
Caregivers ' attitudes about aggression can influence their interaction with people with dementia.
Caregivers ' beliefs about the effectiveness of dementia treatment , their expectations and changes in their lives were clear.
Caregivers do not always seem to be aware that multiple approaches are available to them when dealing with dementia.
Caregivers emphasize the benefits of social connectedness , physical health , and mental stimulation.
Caregiver's experience and the institutional culture may affect the choice of intervention used , either positively or negatively.
Caregivers face a heavy care burden , and decreased physical and mental health ( MH ) .
Caregivers have an important role in assisting frail and / or disabled individuals to maintain their independence in the community.
Caregivers helping with injecting medications were less likely to seek information ( odds ratio @number@ @percent@ CI @number@ to @number@ ) .
Caregivers identified positively with the role of care provider and they did not describe it as burdensome nor did they describe role strain.
Caregivers in the control group were given a DVD containing educational information about dementia caregiving.
Caregivers in the intervention group also reported significantly more gain in self-efficacy in obtaining respite than the control group.
Caregivers ' life experience and self-confidence were considered assets that facilitated medication management.
Caregivers ( N = @number@ ) responded to questionnaires related to depression , neuropsychiatric symptoms , and caregiver burden at baseline and 1-month postintervention.
Caregivers of children and adolescents with HIV infection in follow-up at @number@ reference centers for pediatric AIDS were enrolled.
Caregivers of older adults experience significant physical , emotional , and financial burden , which is associated with poor physical and mental health.
Caregivers of patients tolerating GT placement reported significant improvements in mealtime satisfaction and participation in daily activities.
Caregivers of patients with bvFTD reported poorer sleep quality compared to the SD caregivers.
Caregivers often suffer from depression and neglect their own health in order to care for their loved one.
Caregivers ( @percent@ ) believed that the program should be provided by the VA to caregivers.
Caregivers performed at ceiling in the memory task.
Caregivers recorded PWD baseline characteristics and noted ER visits over the next year.
Caregivers reported significantly more behavioral concerns in males , including internalizing , externalizing , and other maladaptive behaviors.
Caregivers sought information primarily on their own either through online resources or asking friends or relatives ( @percent@ ) .
Caregivers taking a We / Us approach , however , were able to identify more positive aspects of caregiving.
Caregivers who received the FITT-C used community support services at end of treatment significantly more than those receiving TS ( P = @number@ ) .
Caregiving burden was assessed with a short version of the Zarit Burden Inventory.
Caregiving came to seem less important than research aimed at a cure , and the stigma surrounding dementia has , if anything , increased.
Caregiving effects were similar across race and sex.
Caregiving had a strong moral meaning for all participants , particularly for children providing care to a parent.
Caregiving research , intervention efforts , and caregiving programs and services in Native communities should pay special attention to the dynamics of culture and caregiving.
Caregiving stress has been shown to exert negative effect on immune function in both young and old.
Caregiving styles were measured with items from existing scales that had not been analyzed together before.
Care in an assisted living facility costs $ 43 , 500 per person annually.
Care is needed in the selection of analgesic medicine to avoid drug-drug or drug-disease interactions.
Care management for HIV infected individuals will need to draw on a wide range of medical disciplines in diagnosis and treatment.
Care might be improved by the early identification of those who are frail and at highest risk for adverse outcomes.
Care must be exercised in the use of Raman spectroscopy for the identification of blood in forensic applications.
Care must be taken to avoid infringement of the elderly patient’s autonomy by limiting or distorting information given to the patient.
Care must be taken to avoid underestimating amyloid-associated morphologic changes in DS due to disproportionate size of some subcortical structures and thickness of the cortex.
Care of elderly patients with esophageal cancer has relied on past experience.
Care of individuals with dementia should focus on management of comorbidities.
Care provided to these residents should be guided by their goals of care rather than estimated life expectancy.
Care providers and older adults used different conversational strategies when responding to call takers.
Care providers had significant improvement in mood and perceived reduced burden.
Care providers should be aware of this decline and focus on maintaining as much independence as possible.
Care recipient needs ( @percent@ ) , caregiver needs ( @percent@ ) , and decision-making ( @percent@ ) were the most frequently reported stressors.
Care recipients used the system independently but were limited by cognitive and physical impairments.
Care recipient use of community or medical resources did not differ according to group.
Carers provide critical insight into the needs and behaviors of patients as well as processes that need to be improved to enhance their experience.
Care should be made to avoid skin sensitizers , such as lanolin , aloe vera , and parabens , that are commonly found in emollients.
Care staff and family members would also benefit from greater sharing of information about the person with dementia.
Care staff completed a standardized person-directed care questionnaire.
Care templates on gender equal patient encounters should be implemented to better address transgender health needs in a non-biased manner.
Careworkers reported distress as a result of the tensions between the organization of work and the needs of relational care.
CARG GA is feasible.
Cargoes can be differentially blocked in some disorders , either individually or in groups.
Cargoes can include large protein aggregates , organelles , or even pathogens.
Caribbean Hispanics are known to have an elevated risk for AD and tend to have large families with evidence of inbreeding.
Caries prevalence ( DMFT > 0 ) and active caries prevalence ( DT > 0 ) were @percent@ and @percent@ , respectively.
Caries remains a clinical problem that affects both the crowns and the roots of teeth.
Caring for a family member with dementia has been associated with negative health outcomes that are likely related to physiologic changes resulting from stress.
Caring for a patient with AD carries a significant physical , socioeconomic and psychological burden.
Caring for a relative with dementia is extremely challenging ; conventional interventions may not be highly effective or easily available on some occasions.
Caring for older adults is a major function of emergency medical services ( EMS ) .
Caring for persons with Alzheimer's disease presents neurologists with ethical challenges.
Caring for someone with dementia can be demanding , particularly for spouses living with the care recipient.
CARM1 physically and functionally interacted with the NICD-coactivator complex and was found at gene enhancers in a Notch-dependent manner.
Carnitine acetylation enables the function of CoA and facilitates elimination of oxidative products.
Carnosic acid is therefore a potential treatment for the toxic central nervous system ( CNS ) effects of cyanide poisoning.
Carnosine-propanals formed covalent adducts with nucleophilic amino acids leading to the generation of carnosinylated proteins.
Carnosine ( β-alanyl-L-histidine ) is synthesized in mammalian skeletal muscle.
Carnosine ( β-alanyl-l-histidine ) was discovered in @number@ as an abundant non-protein nitrogen-containing compound of meat.
Carolinas HealthCare System developed a 3-pronged approach to this opportunity.
Carotenoid consumption also improves the metabolic profile , decreasing the incidence of diabetes , lowering LDL levels , and improving blood pressure control.
Carotenoid level changes were established from follow-up round @number@ to round @number@
Carotenoids are a group of polyphenolic compounds found predominantly in fruit and vegetables that have been proposed to have anti-inflammatory and antioxidant effects.
Carotenoids can serve as marker substances for the complete antioxidative network of human skin.
Carotenoids may help to prevent the ageing of the brain.
Carotid artery intima-media thickness ( IMT ) and lumen diameter were measured on ultrasound images.
Carotid artery lumen diameters by ultrasound and brachial artery blood pressures were measured at systole and diastole.
Carotid AS parameters were obtained from echo-tracking.
Carotid baroreceptor reflex ( CBR ) control of HR and mean arterial pressure ( MAP ) were assessed by a neck pressure-neck suction protocol.
Carotid blood pressure waveforms were measured prerandomization in a subset of @number@ patients in the Second Australian National Blood Pressure Study.
Carotid doppler , echocardiography , and thyroid functions were done for selected cases.
Carotid endarterectomy ( CEA ) has been evaluated in several studies ; mainly ACAS and ACST.
Carotid-femoral aortic pulse wave velocity was assessed using standard methodologies.
Carotid-femoral pulse-wave velocity and femoral-ankle pulse-wave velocity were measured in both groups at baseline and again at the end of the 12-week study period.
Carotid-femoral pulse wave velocity ( cfPWV ) was measured by Complior system.
Carotid-femoral pulse wave velocity is considered the gold standard for measurements of central arterial stiffness obtained through noninvasive methods ( @number@ ) .
Carotid-femoral pulse wave velocity ( PWV ) , a marker of arterial stiffness , is an established independent cardiovascular risk factor.
Carotid-femoral pulse wave velocity ( PWV ) was measured to obtain data on vascular compliance.
Carotid-femoral pulse wave velocity was measured to assess central arterial stiffness.
Carotid-femoral PWV was calculated by arterial tonometry.
Carotid intima media thickness ( cIMT ) and carotid artery plaque were assessed using ultrasonography.
Carotid intima-media thickness ( cIMT ) and carotid artery stenosis were assessed by ultrasonography.
Carotid intima-media thickness ( cIMT ) was measured by ultrasonography , following the Mannheim protocol.
Carotid intima-media thickness ( IMT ) and brachial-ankle pulse wave velocity ( baPWV ) were measured as indices for atherosclerosis.
Carotid plaques were found in one adult and @number@ older people.
Carotid revascularization with either endarterectomy or stenting can benefit select patients with severe stenosis.
Carotid stenosis was symptomatic in @percent@.
Carotid / vertebral distribution was 72% / 28% and was not related to age , sex , or brain volume.
Carotid wall mass was calculated as ρL ( πRe ( @number@ ) -Ri ( @number@ ) ) .
Carriage of the IL1RN haplotype influenced the age relationship with severity.
Carriers had higher nonmotor symptoms score on the Nonmotor symptoms ( NMS ) questionnaire ( P = @number@ ) .
Carriers of additional Mendelian gene variants have younger ages at onset ( AAO ) .
Carriers of the APOE E4 allele have an increased risk of developing Alzheimer's disease.
Carriers of the apolipoprotein E ( ApoE ) -ε4 genotype have been shown to have greater mesial temporal atrophy and poorer memory functions than non-carriers.
Carriers of the CACNA1C allele A exhibited greater left mOFC thickness compared to non-carriers.
Carriers of the mtDNA haplogroup H had higher levels while carriers of the mtDNA haplogroup J showed lower levels.
Carriers of the ε4 allele tend to be the most responsive to changes in dietary fat and cholesterol.
Carriers reported significantly earlier graying of hair than noncarriers.
Carrier systems for lipophilic drugs , such as the liquid crystalline systems ( LCS ) have been extensively studied to improve effect and selectivity.
Carrying the APOEε4 allele was associated with a significant decrease of the Aβ1-42 concentrations in middle-aged and older participants.
CARS2 ( cysteinyl-tRNA synthetase @number@ mitochondrial ) messenger RNA analysis was performed by reverse transcription PCR and sequencing.
Cartilage and adipose tissue are also likely to participate to this control loop and should not be set aside.
Cartilage and synovial membrane from patients with rheumatoid arthritis ( RA ) and osteoarthritis ( OA ) have high levels of NO.
Cartilage damage and OA progression were detected by the use of fluorescence-imaging ( IVIS ) and histopathology.
Cartilage damage and / or aging effects can cause constant pain , which limits the patient's quality of life.
Cartilage T1 rho values correlated positively with aging for all cartilage regions and all age groups ( p < 0.001 ) .
Cartilage thickness at the various sites was significantly greater in boys than in girls ( P ≤ @number@ ) .
Cartilaginous remnants within the atlas and axis have been shown to variably persist throughout childhood and may be mistaken for fractures.
Car use was recorded with a standard binary question.
CAR was calculated as difference of the cortisol levels at T0 and T30.
Cary North Carolina ) in association with SPSS version @number@ and statistics analysis.
Case 1 : A 71-year-old man had hard palate cancer and had received wide excision in our hospital @number@ years previously.
Case 2 : A 72-year-old woman was a patient with left palate mucoepidermoid carcinoma.
Case ascertainment in most previous studies was based on autopsy data or clinical convenience samples , often without detailed clinical or radiologic information.
Case-control comparisons were performed including digital pathological assessments for detailed analyses of blood vessel morphology.
Case-control studies are reductionist paradigms that assume , for maximum power , that the two populations being compared are exclusive and homogenous.
Case-control studies have associated blood leukocyte DNA hypomethylation with several cancers.
Case-control study showed that there were significant differences between the stable and recurrence groups in age and number of teeth.
Case-fatality , prevalence , and incidence rates were calculated.
Case finding is warranted for urinary incontinence in younger men with a history of military service.
Case identification was based on confirmed outpatient diagnoses , main and secondary hospital discharge diagnoses as well as medications for HF.
Case managers would be responsible for coordinating the care , controlling the quality of services and reassessing needs according to changes in individuals ' conditions.
Case-mix adjusted models for mortality and major complication rate were developed.
CASE PRESENTATION : A 74-year-old Japanese man with asthma-COPD overlap underwent emergency surgery for a ruptured abdominal aortic aneurysm.
CASE PRESENTATION : We report the case of an elderly patient with symptomatic PHPT and incidental pulmonary embolism.
CASE REPORT A 63-year-old woman whose chief complaints were right shoulder and upper extremity pain underwent MRI and 18F-FDG PET / CT scan.
Case reports from Johan Czermak , Marc Ruffer , and others a century or more ago demonstrated ancient Egyptians had atherosclerosis three millennia ago.
Case reports of cranio-orofacial SBD highlight the rarity of this presentation.
Case reports suggest liver damage may occur at therapeutic doses.
CASE REPORTS : Two oronasal fistula cases were reported in this series.
CASE REPORT : We describe a case of five years old male with polymalformative syndrome with a systemic involvement.
CASE REPORT : We report the case of baby IV , a 4-year old girl who presented with clinical and radiologic features consistent with progeria.
Cases and controls included children with and without myelomeningocele , respectively , and their mothers.
Cases and controls were identified by global facial skin aging severity including intrinsic and extrinsic parameters.
Cases and controls were matched on date of study enrollment , age at enrollment , and smoking status and amount.
Cases and controls were of European ancestry.
Cases enrolled between @number@ and @number@ were extracted , and dual entries in the two databases merged.
Case series evidence suggests that these fillers achieve their objective , which is to decrease the visible effects of age-related changes.
CASES : Four patients of different ages presented with gingival swelling and other different complaints.
Cases had higher plasma levels of uncarboxylated MGP ( ucMGP ) and carboxylated MGP ( cMGP ) than controls.
Cases included adults who completed the baseline interview and died before the follow-up interview and for whom a proxy interview was obtained in @number@
Cases included persons aged @number@ years and older who were nonfatally injured on a public roadway.
Cases included were those for whom both spoligotyping and 12-locus-MIRU-VNTR results were available.
Cases ( n = @number@ ) included individuals who were cancer-free at study enrollment but developed lung cancer during follow-up.
Cases ( n = @number@ ) were from a repository of SCA in the greater Seattle area.
Cases of Crohn's disease ( CD ) and ulcerative colitis ( UC ) were identified from medical record review.
Cases of haematologic malignancies with an incidence of less than @number@ per @number@ were selected for analysis.
Cases of osteoporosis that have a specific cause are defined as secondary osteoporosis.
Cases received an average excess public transfer income of € @number@ before vs. € @number@ after diagnosis.
Case studies consisted of in-depth narrative style interviews ( n = @number@ ) with multiple family members , including the older dependent person.
CASES : We present three cases of patients admitted for GI bleeding.
Cases were analyzed in two time periods ( @date@ and 1998-2002 ) to facilitate the study of time trends.
Cases were categorized as clinically relevant depressive symptoms or as depressive syndromes , the latter including Diagnostic and Statistical Manual of Mental Disorders-IV-defined depressive disorders.
Cases were documented into a web-based case report form , and centres provided data on standards regarding prophylactic and diagnostic measures.
Cases were evaluated using persons with life expectancy at birth from @number@ to @number@ years.
Cases were excluded for insufficient data , diabetes mellitus with dysregulated blood glucose , or prolapse greater than 1cm to avoid confusing bladder outlet obstruction.
Cases were identified as children who developed ≥2 episodes of physician-recorded LRTIs during the first year of life and controls as children who had none.
Cases were identified as patients who died anytime between @date@ and @date@ .
Cases were identified from local hospitals and rural health clinics served by Dhaka Community Hospital.
Cases were patients with falls and fall-related injuries , and controls were patients admitted for infections.
Cases were selected using ICD- @date@ codes.
Cases were the @number@ patients who experienced the outcome ( hospitalization for UGIC ) until @number@
Cases were those diagnosed of PCa and had one or more measurements of testosterone prior to PCa diagnosis.
Cases with greater deposits of iron also had other signs of stasis , such as neovascularization.
Cases with higher female VM are rare exceptions and appear in particular in the highest age groups.
Cases without WRN mutations are operationally categorized as ' atypical WS ' ( AWS ) .
CASI scores were higher for younger cohorts and men due to differences in education levels.
CASP3 protein was up-regulated in fibroblasts of DS.
CASP9 protein has an important role in the mitochondrial cell death pathway as the initiator of apoptosis.
Caspase-12 ( Casp12 ) , an inflammatory caspase , functions as a dominant-negative regulator of inflammatory responses and is associated with the signaling of apoptosis.
Caspase-1 and caspase-11 have roles in inflammation and mediating inflammatory cell death by pyroptosis.
Caspase-1 ( Casp1 ) can activate Casp6 but the expression and functionality of Casp1-activating inflammasomes has not been well-defined in human neurons.
Caspase-2 has been shown to function in apoptosis and in some non-apoptotic pathways , including tumor suppression and aging.
Caspase-2 has some unique features and is the only caspase that constitutively localizes to the nucleus , although its nuclear function remains unknown.
Caspase-3 and calpain activities in age-matched controls and AD patients were about three times those of young adult controls.
Caspase-3 and caspase-8 mRNA and cleaved protein levels were investigated by RT-PCR and western blotting , respectively.
Caspase-3 ( CASP3 ) plays an important role in neuronal death during nervous system development and under certain pathological conditions.
Caspase-3 has important roles in tissue differentiation , regeneration and neural development in ways that are distinct and do not involve any apoptotic activity.
Caspase-6 active p20 subunits were only detected in fetal stomach.
Caspase-6 ( Casp6 ) activation in the brain is implicated early in the pathogenesis of Alzheimer disease ( AD ) .
Caspase-6 induces neuronal degeneration and inflammation.
Caspase-6 is an effector caspase that has not been investigated thoroughly despite the fact that Caspase-6 is strongly activated in Alzheimer disease brains.
Caspase-8 also functions in maintenance and homeostasis of the adult T-cell population.
Caspase activity was measured using a colorimetric assay.
Caspase cleaved amyloid precursor protein ( APPcc ) and SET are increased and mislocalized in the neuronal cytoplasm in Alzheimer Disease ( AD ) brains.
Caspase-mediated proteolysis also controls diverse nonlethal cellular activities such as proliferation , differentiation , cell fate decision , and cytoskeletal reorganization.
Caspases are at the core of executing apoptosis by orchestrating cellular destruction with proteolytic cascades.
Caspases are cysteine-proteases with key roles in the execution phase of apoptosis.
Caspases are proteases with a well-defined role in apoptosis.
Caspases , initially identified as a family of proteases regulating cell death , have been found to have nonapoptotic functions as well.
Cassel's assessment of the research and practice implications of his conclusions has remarkable contemporary resonance for the field of epidemiology.
Cassel's provocative thesis was anchored in a cogent synthesis of findings from animal experiments and observational studies on diverse human populations.
Castilla-La Mancha Health Service is developing the integration of care levels due to the challenge of an aging population in the region.
Catabolic pathways involve inflammation and the transcription factor nuclear factor-κB.
CAT activity was higher after scuba diving and , dive @number@ enhanced mRNA gene expression of CAT , GPx and SOD.
Catalase and GPx activity were similar in MCI and healthy individuals but higher in AD.
Catalase is involved in hydrogen peroxide catabolism and is important in defense against oxidative stress.
Catalytic scavenging of soman in mice improved the therapeutic outcome and resulted in the delayed onset of toxicity symptoms.
Cataplexy was present in @number@ of @number@ patients and hypocretin-1 deficiency was present in @number@ of @number@ patients.
Cataract and glaucoma were the main causes of visual disabilities.
Cataract associated with the aging process ( senile ) is the most common type.
Cataract development had early onset more frequently in cases of PSC followed by CC and NC.
Cataract development was seen at various postnatal days in the majority of mice expressing active APH ( wt-APH ) .
Cataract formation in the elderly is not linked to a WRN mutation.
Cataract is a total or partial clouding of the lens of the eye.
Cataract is a visible opacity in the lens substance , which , when located on the visual axis , leads to visual loss.
Cataract is the leading cause of visual impairment , other than uncorrected refractive errors , and the number one cause of preventable blindness worldwide.
Cataract onset and severity of the cataracts correlated with the APH protein levels.
Cataracts are crystalline lens opacities leading to a loss of visual acuity.
Cataracts are irreversible.
Cataracts etiology is varied and treatment is based on surgery.
Cataracts mainly affect the elderly , and are more or less incapacitating depending on their intensity and location.
Cataract surgical coverage was calculated.
Cataract surgical coverage was @percent@.
Cataract was graded by one ophthalmologist using the Lens Opacities Classification System III.
Catastrophic health-care expenditure ( CHCE ) is one of the driving forces for retirees to go to paid work.
Catch-up growth ( CUG ) was defined when weight during the first year was > 0.67 of the standard score , according to WHO data.
Catch-up growth however , continued throughout the whole of childhood.
Catch-up growth was defined as an increase of @number@ Z score in weight between measurements.
Catch-up saccades during pursuit occurred more frequently during surface perturbations.
Catecholamines play a key role in the regulation of cardiovascular function , classically through ß ( @date@ ) -adrenoreceptors ( AR ) activation.
Categorical perception was assessed in an identity-classification task and a discrimination task.
Categories of caregiver mental-health trajectory groups were identified by latent-class finite-mixture modeling.
Categories of sexual activity frequency in the previous four weeks ranged from zero to 12 + times.
Categories were integrated using the constant comparison method.
Catel-Manzke syndrome is characterized by Pierre Robin sequence and a unique form of bilateral hyperphalangy causing a clinodactyly of the index finger.
Cathepsin D and transglutaminase ( TGase ) -1 in the skin sublayers were separated and detected via tape stripping , ELISA and Western blot.
Cathepsin X is a lysosomal cysteine protease that functions as a carboxypeptidase with broad substrate specificity.
Cathepsin X was discovered only recently , and its physiological roles are still not well understood.
Catheter ablation ( CA ) is a procedure commonly used to restore sinus rhythm in patients with atrial fibrillation ( AF ) .
Catheter failure rate was significantly reduced with the performance of omentectomy ( @percent@ without omentectomy vs @percent@ with omentectomy , P = @number@ ) .
Catheter failure was observed in @number@ children ( @percent@ ) .
Catheter obstruction was identified in @percent@.
Cationic liposomes are widely used as nanocarriers for therapeutic and diagnostic purposes.
Cationic nanobubbles caused a concentration-dependent cytotoxicity of degranulation ( elastase release ) and membrane damage ( release of lactate dehydrogenase , LDH ) .
Cationic surfactants in both nanoparticulate and free forms induced cell death and the release of mediators.
Caucasian eyes seem to benefit the most , as cell survival is the worst on submacular Bruch's membrane in these eyes.
Caudal width was greater than the cranial width.
Caudate nucleus and thalamus volumes were unaffected by the intervention.
Causal errors increased in AD patients when stories included affective ( positive or negative ) outcomes.
Causality cannot be inferred , and limitations include low quality of studies and possible confounding.
Causality cannot be inferred but cardiovascular risk reduction should be emphasized in these patients.
Causality of BMI for endometrial cancer was assessed using Mendelian randomization , with BMIwGRS as instrumental variable.
Causality with respect to cognitive outcomes is , therefore , difficult to infer.
Causal mediation analyses show that endophenotypes explained only small fractions of these effects.
Causal treatment of insomnia is necessary keeping in consideration that depressive dimension can , afterward , evolve on its own.
Causative mutations were detected in @number@ patients in the familial group ( @percent@ ) .
Causative strains of cystitis were diverse , and some were antibiotic resistant.
Cause of death was classified as follows : malignant neoplasms , dementia , circulatory disease , respiratory disease , digestive system disease , and other.
Cause of death was classified by a committee of physicians reviewing death certificates , medical records , and informant interviews.
Causes for age-related retinal diseases are numerous and complex , and they are intertwined with the natural vision decline that accompanies aging.
Causes for these complaints may vary across age groups.
Causes of death for French Olympic athletes and female elite athletes have not been studied.
Causes of death were obtained from @number@
Causes of death were obtained via the National Death registry from @number@ to @number@
Causes of facial structural aging include gravity , volume loss , contraction of the mimic muscles and obviously biological aging of tissues.
Cause-specific models were considered for cancer and CM.
Cause-specific mortality , chronic disease and functioning were ascertained from hospital data , register linkage and clinical examinations.
Cause-specific mortality data were also included.
Cause-specific mortality estimates were transformed into incidence estimates using mortality incidence ratios.
Caution and nondecision time both increased significantly with age while bias towards the Go response decreased.
Caution in PMMA microsphere injection should be given in the patient with prior blepharoplasty.
Caution is hence needed when applying the commonly used mediation tests in genome-wide mediation studies.
Caution is needed when interpreting clinical studies of PD , especially studies of early disease that do not have autopsy confirmation.
Caution is needed when using DTI metrics for diagnosis of various neurological diseases involving abnormal iron deposition.
Caution should also be taken for the type of additives used.
Caution should be taken when selecting feasible nanoparticulate formulations and cationic additives for consideration of applicability and toxicity.
Cautions to extrapolate observation in rodents to explain human conditions have been presented.
Cautious uptitration of the individual drugs and vigorous clinical and laboratory monitoring is mandatory to avoid undesired side effects.
Caveolin-1 ( Cav-1 ) is one of the key molecules to modulate collagen metabolism in the skin.
Caveolin-1 expression is diminished in PBOO-induced BSM hypertrophy in mice and in men with BPH.
Caveolin-3 is a muscle-specific membrane protein that localizes to the sarcolemma and T-tubule system.
Caveolin-3 is needed for muscle repair and skeletal muscle development.
Caveolin-3 was abnormally expressed in the MG muscle membrane , with partial loss of expression and overexpression in @date@ and @date@ patients , respectively.
Caveolin , a member of the membrane-anchoring protein family , accumulates various growth receptors in caveolae and inhibits their function.
CAVI in the subjects with abnormal waist circumference was significantly higher than that obtained in the normal subjects ( P < @number@ ) .
CAVI showed a positive correlation with waist circumference and increased significantly with the number of metabolic syndrome components.
Cavitary , miliary and pneumonic radiographic patterns were all significant predictive factors for TB-related death.
Cavities were restored with composite resins in an \ "open sandwich \ " technique.
CAVI was assessed by a VaSera VS-1000 instrument.
CAVI was measured noninvasively using a Vasera VS-1000 device.
CAVI was significantly reduced at @number@ month compared with the baseline from @number@ ± @number@ to @number@ ± @number@ ( p = @number@ ) .
CAVS was thought to be a passive , degenerative process , whereas now the progression of calcification in CAVS is considered to be actively regulated.
Cavus foot posture was not associated with the foot disorders evaluated.
Ca ( v ) βs oligomerize at the α ( 1C ) subunits residing in the plasma membrane and bind to the AID.
CA was found to diminish nitric oxide ( NO ) and prostaglandin E2 ( PGE2 ) production in LPS-stimulated RAW264.7 cells.
CAXII expression has been also detected in several tissues , whereas in cancer and tumor tissues its expression is several fold higher.
CAXII is also seen in nuclear pulposus cells of the vertebrae.
CAXII plays a key role in several physiological functions.
CB1 availability did not differ significantly between advanced PD patients with and without LID.
CBDP ( 2- ( ortho-cresyl ) -4H-1 , 2 , ) is the toxic metabolite of triortho-cresylphosphate , a component of TCP.
CBDP is the first organophosphorus agent that leads to a fully dealkylated phospho-serine BChE adduct.
CBDP-phosphorylated cholinesterases are nonreactivatable due to ultra fast aging.
CBF and cardiac output were measured in @number@ healthy subjects 50-75 years old using magnetic resonance imaging techniques.
CBF decreased more in response to the upright posture in the HF group than in the control group ( p = @number@ ) .
CBF regulation associated with cerebral metabolism thus likely plays an important role in the preservation of cognitive function.
CBFV was higher and change in CBFV due to respiratory manoeuvre was significantly greater in the younger group compared with the older group.
CBF was evaluated by colour duplex sonography of extracranial arteries.
CBF was measured with pseudocontinuous arterial spin labeling at 3T in the whole brain and in partial volume corrected cortical maps.
CBI is an important consideration in the treatment of cosmetically disfiguring dermatologic disorders.
Cbln4 immunoreactivity was found in the hippocampus , mostly in the dendrites and somata of pyramidal neurons.
CBRs exert tonic control over GIP secretion , which may have a homeostatic effect in suppressing GLP-1 secretion.
CBs are impregnated with thousands of chemical compounds , many of which are highly toxic and none of which has history of resistance in mosquitoes.
CBT had a @percent@ chance of being the dominant strategy , with results most sensitive to an older adult's baseline risk of falling.
CBX4 was one of the HDAC7 E3 ligases involved in this process.
CCAs and BAs of healthy adolescents were investigated.
CC females exhibited higher A. lumbricoides loads than UV females , while the opposite pattern was observed for T. trichiura infection in males.
CCFM scores ( 0-20 ) can be used as a continuous outcome or to adjust for cognition in a multivariable analysis.
CCFM scores were highly correlated with MoCA scores ( r = @number@ ) .
CCI and combined Charlson-age index significantly predicted outcome in the unadjusted , but not adjusted analysis.
CC is an important anthropometric indicator of current functional ability among older adults.
CCL19- but not CCL21-dependent chemotaxis was decreased in aMCI and mAD , despite the fact that CCR7 expression was increased in aMCI.
CCN1 and IL-1β are strikingly induced by acute UV irradiation , and constitutively elevated in sun-exposed prematurely aged human skin.
CCN1 mRNA was upregulated 113-fold in muscle of aged vs. young rats.
CCN1 protein was increased in aging muscle in both rats ( @number@.8-fold ) and mice ( @number@.8-fold ) .
CCR2 expression was also positively associated with apolipoprotein E ( ApoE ) e4 Alzheimer disease risk haplotype.
CCR2 is also important in neurogenesis.
Ccr decreased about @percent@ from the young to oldest group ( p < 0.001 ) .
CCSVI is characterized by abnormalities of the main extracranial cerebrospinal venous outflow routes that may interfere with normal venous outflow.
CCT , acting as an external protective mechanism , seems to modify this standardized response , avoiding BDNF increase or possibly modifying its time course.
CCT also decreases , but its dependence on age is weaker.
CCT decreased from @number@ ± @number@ μm preoperatively to @number@ ± @number@ μm ( P < @number@ ) at @number@ months.
CCT did not correlate with either age ( r = @number@ ) or refraction ( r = @number@ ) .
CD11c + T-bet + B cells have now been detected and characterized in different experimental and clinical settings , in both mice and humans.
CD14 ( + ) CD16 ( + ) inflammatory monocytes were induced after vaccination in both young and older adults.
CD18 levels in the elderly injured subjects for all three time periods were significantly higher than both control groups.
CD200 is a transmembrane protein that belongs to the immunoglobulin family of proteins and is ubiquitously expressed on a variety of cell types.
CD200 negatively correlated with density of neurofibrillary tangles , phosphorylated tau , and amyloid plaque density.
CD21 ( low ) CD38 ( low ) B cells as well as plasmablasts do not exhibit developmental changes.
CD271 is common stem cell marker for the epidermis and dermis.
CD28 + cells showed an immature phenotype associated with high frequencies of CD45RA and CD31.
CD28 costimulatory signal transduction in T lymphocytes is essential for optimal telomerase activity , stabilization of cytokine mRNAs , and glucose metabolism.
CD28 expression distinguished two subsets of CD4 + NKG2D + cells with distinct functional properties and differentiation status.
CD29 was increased in elderly healthy individuals compared to the control young group ( p = 0.0001 ) .
CD2AP gene expression in PBL was significantly decreased in patients with SAD as compared with controls.
CD31 ( + ) T cells , or so-called \ "angiogenic T cells , \ " have been shown to demonstrate vasculoprotective and neovasculogenic qualities.
CD31 ( + ) T cells were isolated from peripheral blood samples by magnetic-activated cell sorting.
CD33 inhibitors may include humanized CD33 antibodies such as lintuzumab which was safe but ineffective in AML clinical trials.
CD34-positive myeloid progenitor cells are considered as a site of latency.
CD34 ( Shh ) primarily store and secrete Shh protein in exosomes and this storage process appears to be cell-type specific.
CD34 was ubiquitously expressed by all ECs in both ccRCC and non-neoplastic renal tissues.
CD3CD4CD25high and CD3CD4CD25highCD127high cells were also significantly increased in asthmatic patients , while CD3CD4CD25highCD127low cells had similar values in asthmatics and in the control group.
CD40 and BAFFR signaling play important roles in B cell proliferation and Ig production.
CD44v6 positivity was significantly associated with tumour-node-metastasis ( TNM ) stage and lymph node involvement.
CD45RA was significantly decreased in elderly individuals ( p < 0.05 ) and this decrease was higher in asthmatics ( p < 0.05 ) .
Cd47 ( - / - ) mice weighed less and had decreased areal bone mineral density compared with controls.
CD49d is an alpha subunit of the VLA-4 ( α4β1 ) integrin.
CD4 / CD8 ratios rose to ≥1 in @percent@ of patients , whereas CD4 counts went ≥500 / µl in @percent@.
CD4 count and efavirenz use in HIV-infected participants were associated with increasing SM , whereas age and stavudine use were associated with decreasing SM.
CD4 + counts and viral loads were obtained from the National Laboratory results system.
CD4HLA-DR cells were within the normal range in both groups.
CD4 ( + ) regulatory T cells ( Tregs ) are a distinct population of T cells involved in maintaining peripheral tolerance to self-antigens.
CD4 T cells and cellular activation may influence ovarian granulosa cell function.
CD56 + monocytes represent a different subpopulation , which is also expanded in conditions associated with autoimmunity like inflammatory bowel diseases.
CD57 is also expressed on tumor cells of neural crest origin and has been preferentially found on highly aggressive , undifferentiated , multipotent CSC-like cells.
CD59 , another GPI-linked protein that protects against complement-induced removal , also remains constant during storage.
CD5 expression was downregulated by IL-15-mediated signaling in vitro and CD5 ( lo ) memory T cells accumulated in the bone marrow.
CD80 expression in tumor-spheroid infiltrating mPGES-1 ( - / - ) macrophages translated into antigen-specific cytotoxic T cell activation.
CD8 CONCLUSIONS : These results demonstrate that chronic systemic inflammation observed in obesity induces dysfunctional features in PBMC that are consistent with premature immunosenescence.
CD8 + T-cell counts may add additional AMI risk stratification information beyond that provided by CD4 + T-cell counts alone.
CD8 T cells play a critical role in mediating RSV clearance.
CD8 + T-lymphocytes from young athletes had reduced TREC content and lower frequencies of recent thymic emigrants.
CD95 expression on unstimulated A-T lymphocytes was high , and the apoptotic sensitivity of activated naive and central memory T cells was increased.
CD95 lymphocytes increased in elderly ( p = 0.0001 ) and a positive correlation between age and CD95 ( p < 0.05 ) was found.
CD98hc transiently accumulates around the bacteria during the early phases of infection and is required for both optimal bacterial uptake and intracellular multiplication of Brucella.
CD also increased with age in the neck skin.
Cd and Pb tended to increase in association with age , whereas Cr , Mn and Ni tended to decrease.
Cdc37 may also be involved in other aspects of pathophysiology.
CDC reports indicate > 41 , 000 clinical cases , including more than @number@ fatalities.
CDH can be divided into two forms , based on headache duration.
CDK5 , CK1δ and JNK were detected only on the rim.
CDK5RAP2 is a component of the pericentriolar material important for the microtubule-organizing function of the centrosome.
CDKN1A ( p21 ) and CDKN2A ( p16 ) inhibit CDK4 / 6 , initiating senescence.
CDR1 mRNA expression was evaluated by qRT-PCR.
CDR increased with retinal nerve fiber layer ( RNFL ) thinning ( r = -0.29 , p = 0.001 ) .
CdSe NPs loaded with Qe , these QCZ NPs exhibited excellent antibacterial ( E. coli and B. subtilis ) and anticancer ( BGC-823 ) activities.
CDSMP may be integrated into primary care services for older adults.
CDTs exert cytopathic effets , via their active CdtB subunit.
CEBPD in astrocytes is associated with microglia activation and migration in amyloid precursor protein transgenic mice ( AppTg ) mice.
CEBPD is upregulated in the astrocytes of AD patients.
C , EB-Querc ) or increased ( SB-Querc , CSE-Vit.
CEC migration across RPE was greater after RPE exposure to peroxide to induce VEGF₁₈₉ ; VEGFR2 and Rac1 activities were also increased in these CECs.
CECs decreased over time and were significantly reduced at study end.
Cecutient and healthy children had similar values of steriokinetic illusion in monocular visual conditions , while in binocular visual conditions the results were significantly different.
CEE is a natural formulation of an extract prepared from pregnant mares ' urine.
CEE is most commonly used for the management of early menopausal symptoms such as hot flashes , vaginitis , insomnia , and mood disturbances.
Ceftaroline fosamil is a parenteral cephalosporin indicated for the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia.
Ceftaroline fosamil was generally well tolerated regardless of age or severity of renal impairment.
Ceftaroline pharmacokinetic parameters varied with different degrees of renal impairment , resulting in recommended dosage adjustments for patients with moderate to severe impairment.
C. elegans , a @number@ mm long roundworm , is a popular model organism in almost all areas of modern biology.
C. elegans displays age-related decline of some biological processes observed in ageing humans , and about @percent@ of C. elegans ' genes have human homologs.
C. elegans has been instrumental in expanding our mechanism-based knowledge of PD , and this species is emerging as a good model of obesity.
C. elegans is a commonly used laboratory animal for studying ageing.
Celiac disease ( CD ) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma.
Cell.
Cell.
Cell aging was detected by Senescence β-Galactosidase ( SA-β-gal ) staining.
Cell aging was measured by β-galactosidase approach.
Cell apoptosis induced by anticancer agents was markedly increased.
Cell biological and animal experimental data support this notion.
Cell changes can be divided into three major groups.
Cell count and CSF levels of immunoglobulin and albumin were also measured.
Cell Counting Kit-WST-8 was used to determine the proliferation of lymphocytes in mixed lymphocytes coculture system with different passages of MSC.
Cell counts are often missing or may not be feasible.
Cell culture in charcoal-stripped serum and treatment with enzalutamide inhibited growth of T24GR cells , which was accompanied by cell cycle arrest.
Cell culture studies showed that 17β-estradiol at physiological concentrations did not significantly alter PCSK9 expression in human hepatocytes.
Cell cycle and apoptosis of the PDLSC were examined by the flow cytometry.
Cell cycle-related kinase ( CCRK ) is essential for AR-induced hepatocarcinogenesis but its molecular function in HBV-associated HCC remains obscure.
Cell death caused by high concentrations of H₂O₂ was confirmed to be programmed necrosis.
Cell death mediated by BNIP3 and NIX is implicated in heart disease and ischemic injury.
Cell death was morphologically studied by microscopy using APOPercentage assay and PI staining.
Cell death was observed to be associated with the covalent binding of calmodulin , in parallel , to the regulatory sequences of proteins.
Cell division is both essential for and threatening to proper genome organization.
Cell division is closely related to telomerase activity ( hTERT mRNA ) .
Cell encapsulation potentially improves treatment approaches using viable cells and overcome the immuno-rejection following cell transplantation.
Cell-extrinsic mechanisms , including inflammation and prion-like spreading , are proposed to have both protective and deleterious functions in Parkinson's disease.
Cell growth and proliferation was observed through MTT method after treating with low power laser.
Cell heterogeneity and the inherent complexity due to the interplay of multiple molecular processes within the cell pose difficult challenges for current single-cell biology.
Cell homeostasis and viability are therefore dependent on the removal of oxidatively damaged proteins.
Cell incubation with antioxidants quercetin or genistein prevents 24-hydroxycholesterol's pro-oxidant effect and potentiation of Aβ-induced necrosis and apoptosis.
Cell labeling with division-sensitive markers and competitive transplantation studies have been used to estimate the replication rate of murine HSCs in vivo.
Cell matrix adhesion activated the Hippo pathway effector transcription coactivator YAP partially through Src-mediated phosphorylation and inhibition of LATS1.
Cell morphology , proliferation , colony formation and apoptosis of MGC803-resistant cells were analyzed after @number@ weeks.
Cell phenotype , colony formingunit-fibroblast ( CFU-F ) content , immunomodulation effect and adipogenic , osteoblastic and angiogenic potentials were not significantly different.
Cell phenotype was identified by using the tight junctions cell marker ZO-1.
Cell polarity is a universal biological phenomenon.
Cell polarity proteins are therefore potentially critical regulators of asymmetric cell division.
Cell progeny containing inclusion bodies have a longer cell cycle and increased resistance to stress than those with diffuse Htt.
Cell proliferation and apoptosis assays indicated that the three cell lines had different sensitivities to gefitinib.
Cell proliferation and DNA replication both decreased , and oxidized proteins accumulated , during high H2O2 challenge , but prior H2O2 adaptation was protective.
Cell proliferation and neurogenesis were assessed via bromodeoxyuridine labeling and immunostaining for cell type-specific markers.
Cell proliferation is energetically expensive , so shorter telomeres should lead to a thrifty phenotype.
Cell proliferation was evaluated with Ki-67 antibody.
Cell proliferation was examined by MTT assay.
Cell Proteomics , @number@ 3211-23 ( @number@ ) ) .
Cell replacement has been explored as a therapeutic strategy to repair the brain in patients with Huntington's and Parkinson's disease.
Cell replacement therapy has shown promise.
Cell replication and oxidative stress are factors contributing to erosion of telomeres responsible for maintaining genomic stability and cell replication capability.
Cell responses were assessed at @number@ hours after aerosol exposure.
Cells age in association with deficit accumulation via mechanisms that are far from fully defined.
Cells also change their gene expression profiles to adapt to altering milieus.
Cells are maintained in their differentiated state by selectively activating some genes and silencing.
Cells are under constant assault from reactive oxygen species that occur endogenously or arise from environmental agents.
Cells at risk of accumulating oncogenic mutations are organized into small compartments of cells and proliferate according to a stochastic process.
Cells cultured in serum from CR individuals showed a @percent@ increase in resistance to H2O2 damage.
Cells from human posterior subcapsular cataracts had morphological and molecular characteristics similar to the cells at the posterior of mouse lenses lacking Trp53.
Cells from progeria patients exhibit cell cycle defects in both interphase and mitosis.
Cell shortening and calcium transients were measured on isolated adult cardiomyocytes.
Cells including somatic stem cells have evolved a series of checks and balances to sense and repair cellular damage to maximize tissue function.
Cells in which NQO1 levels were decreased by RNA interference exhibited increased vulnerability to death induced by 2-deoxyglucose and lactacystin.
Cells / islets were incubated for @number@ h with eHSP72 ( @number@ @number@ @number@ @number@ and @number@ ng / ml ) .
Cells lacking CHIP are hypersensitive to DNA-damaging agents , but DNA repair and cell viability are rescued by enforced expression of SirT6.
Cells lacking SCAI display reduced DSB repair capacity , hypersensitivity to DSB-inflicting agents and genome instability.
Cells lacking Vms1 show progressive mitochondrial failure , hypersensitivity to oxidative stress , and decreased chronological life span.
Cell sorting is a process that allows the physical separation of cells based on different characteristics which can be measured by flow cytometry.
Cells possess protein repair pathways to rescue oxidized proteins and restore their functions.
Cells repair DSBs using two major pathways : nonhomologous end joining ( NHEJ ) and homologous recombination ( HR ) .
Cells respond to accumulation of misfolded proteins in the endoplasmic reticulum ( ER ) by activating the unfolded protein response ( UPR ) signaling pathway.
Cells respond to changes in their environment and in their intracellular milieu by altering specific pathways of protein synthesis and degradation.
Cells sense and appropriately respond to the physical conditions and availability of nutrients in their environment.
Cells treated with kaempferol ( 12-100μM ) and 5-FU ( 1-10μM ) , as the positive control , up to 72h.
Cell-surface TLR-9 expression , however , was unaltered on neutrophils from ELD donors.
Cell survival in chronic lymphocytic leukemia ( CLL ) largely depends on B-cell receptor-induced AKT activation.
Cell survival was maintained within all cell aggregates over @number@ weeks of culture.
Cells were cultured for @number@ days and barrier function measured by transepithelial resistance ( TER ) .
Cells were cultured with rhinovirus @number@ at a multiplicity of infection of @number@
Cells were laser capture microdissected from AD ( n = @number@ ) and healthy elderly control ( n = @number@ ) subjects for RNA sequencing.
Cells were then subjected to immunoblotting , clonogenic survival assay , cell growth analysis , and cell death analysis with TUNEL and annexin V staining.
Cells were treated with cytotoxic agents , including Paclitaxel , Etoposide , or ionizing radiation.
Cells were treated with @number@ mM BET at @number@ @number@ @number@ min and @number@ @number@ and @number@ h.
Cell therapy has emerged as an experimental stroke treatment.
Cell therapy is an emerging approach to the treatment of these conditions.
Cell therapy such as platelet rich plasma ( PRP ) has recently emerged as a promising therapeutic tool for many diseases including OA.
Cell therapy that involves the injection of viable cell into patients is a promising therapeutic strategy in chronic and degenerative diseases.
Cell-to-cell variability in receptor expression leads to the formation of complex NK cell repertoires.
Cell transformation of fibrotic fibroblasts cultured into glycated matrices was evaluated in different experimental conditions.
Cell transplantation in the brain presents several immunological challenges.
Cell-type-specific transcription factors emerge at @number@ weeks.
Cellular ageing can lead to altered cell mechanical properties and is known to affect many fundamental physiological cell functions.
Cellular aging altered the EphA2 endocytic route , affecting the maturation of EphA2-containing endosomes and causing premature signal termination.
Cellular aging occurs by the lifelong accumulation of oxidative damage leading to neuronal apoptosis , termed ' neurodegeneration' , and the functional deficits of aging.
Cellular aging processes have similar organelle and signaling association in the retina and brain tissues.
Cellular alterations at the dermal-epidermal junction were clearly prevented.
Cellular and molecular basis of frailty has not been elucidated.
Cellular and organ metabolism affects organismal lifespan.
Cellular atypia was present in all mice with hematoproliferative change , and dysplasia was present in five of eight examined.
Cellular damage and deregulated apoptotic cell death lead to functional impairment , and a main consequence of these events is aging.
Cellular damage is initiated by different stress / risk factors such as oxidative stress , inflammation , and heavy metals.
Cellular data reveal that FL772 is able to inhibit S6K phosphorylation in yeast cells.
Cellular differentiation , developmental processes , and environmental factors challenge the integrity of the proteome in every eukaryotic cell.
Cellular functions of the Nesprins and recent studies on different cancer types additionally draw interest on Nesprins in the field of cancer research.
Cellular glucose uptake and cellular signaling were determined @number@ h post-Ad36 infection or E4orf1-induction , in continued presence of MCP1 or TNFα.
Cellular hallmarks of HGPS include nuclear blebbing , loss of peripheral heterochromatin , defective epigenetic inheritance , altered gene expression , and senescence.
Cellular homeostasis , which is needed for the cells to survive , requires a well-controlled balance in protein turnover.
Cellularity was assessed regarding age , HIV status , and NP.
Cellular maturity has implications for the effectiveness of host response to bacterial or viral infection and / or tissue injury.
Cellular mechanisms of aging and age-related diseases are not completely understood.
Cellular mechanisms of aging and age-related diseases are not completely understood.
Cellular membrane and extracellular collagen composition , not genome integrity , have apparently been the optimized features.
Cellular mitochondria are biochemically and morphologically tailored to provide exponentially enhanced ATP-dependent energy production accordingly to tissue- and organ-specific physiological demands.
Cellular or replicative senescence is classically seen as the key element of aging.
Cellular oxidation promoted REGγ-proteasome-dependent trypsin-like activity by enhancing the interaction between REGγ and 20S proteasome.
Cellular processes and homeostasis control in eukaryotic cells is achieved by the action of regulatory proteins such as protein kinase A ( PKA ) .
Cellular proliferation and osteogenic differentiation potential of hTMSCs also showed no significant differences among the age groups.
Cellular proliferation was measured by an MTT assay.
Cellular radioresistance disappeared completely both in vitro and in vivo with accompanying apoptosis when treated with API-2.
Cellular reprogramming is a means of assigning greater value to primary AFCs by inducing self-renewal and pluripotency and , thus , bypassing senescence.
Cellular responses such as differentiation , proliferation and calcium mobilization were investigated using cultured human keratinocytes and fibroblasts.
Cellular responses to DNA damage are critical determinants of cancer development and aging-associated pathogenesis.
Cellular senescence and AMPK-mTOR signaling markers associated with EMT were detected.
Cellular senescence and metabolic abnormalities driven by OA-associated risk factors appear to accompany epigenetic drifts in chondrocytes.
Cellular senescence and telomere dynamics are linked to the molecular mechanisms that are associated with the onset of labor and parturition.
Cellular senescence and telomere shortening represent suitable and promising targets.
Cellular senescence , an important component of mammalian aging , has recently been associated with decreased heterochromatinization of normally silenced regions of the genome.
Cellular senescence arrests the proliferation of potential cancer cells , and so is a potent tumor suppressive mechanism , akin to apoptosis.
Cellular senescence-associated beta galactosidase activity ( @percent@ vs @percent@ , p = 0.18 ) tended to decrease.
Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-suppressive mechanism.
Cellular senescence can modulate various pathologies and is associated with irreparable DNA double-strand breaks ( IrrDSBs ) .
Cellular senescence contributes to aging and decline in tissue function. p53 isoform switching regulates replicative senescence in cultured fibroblasts and is associated with tumor progression.
Cellular senescence contributes to organismal development , aging , and diverse pathologies , yet available assays to detect senescent cells remain unsatisfactory.
Cellular senescence contributes to tissue and organismal aging , tumor suppression and progress , tissue repair and regeneration , and age-related diseases.
Cellular senescence contributes to tissue and organismal aging , tumor suppression and progress , tissue repair and regeneration , and age-related diseases.
Cellular senescence disables proliferation in damaged cells , and it is relevant for cancer and aging.
Cellular senescence happens in @number@ steps : cell cycle arrest followed , or sometimes preceded , by gerogenic conversion ( geroconversion ) .
Cellular senescence has been shown for epithelial cells of bronchi and alveoli as well as mesenchymal and vascular cells.
Cellular senescence has emerged as a biological response to two major pathophysiological states of our being : cancer and aging.
Cellular senescence has evolved to restrict tumor progression but the accompanying senescence-associated secretory phenotype ( SASP ) promotes pathogenic pathways.
Cellular senescence influences tumor suppression and progress , tissue repair and regeneration , tissue and organismal aging , and age-related diseases.
Cellular senescence-inhibited gene ( CSIG ) protein significantly prolongs the progression of replicative senescence , but its role in tumorigenesis is unclear.
Cellular senescence is a cell fate decision and stress response that entails a permanent arrest of cell proliferation coupled to a complex secretory phenotype.
Cellular senescence is a cell fate program that entails essentially irreversible proliferative arrest in response to damage signals.
Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging.
Cellular senescence is a fundamental cell fate , important both in physiological and pathophysiological processes.
Cellular senescence is a multifactorial phenomenon of growth arrest and distorted function , which has been recognized as a contributor to aging.
Cellular senescence is an age-associated phenomenon that promotes tumor invasiveness owing to the secretion of proinflammatory cytokines , proteases , and growth factors.
Cellular senescence is an effective tumor-suppressive mechanism that causes a stable proliferative arrest in cells with potentially oncogenic alterations.
Cellular senescence is an important in vivo mechanism that prevents the propagation of damaged cells.
Cellular senescence is an important mechanism for preventing the proliferation of potential cancer cells.
Cellular senescence is an important protective mechanism against cell proliferation and has critical roles in aging and aging-related disease.
Cellular senescence is an irreversible cell cycle arrest program in response to various exogenous and endogenous stimuli like telomere dysfunction and DNA damage.
Cellular senescence is an irreversible form of cell cycle arrest that provides a barrier to neoplastic transformation.
Cellular senescence is a physiological process of irreversible cell-cycle arrest that contributes to various physiological and pathological processes of aging.
Cellular senescence is a process that results from a variety of stresses , leading to a state of irreversible growth arrest.
Cellular senescence is a program activated during diverse situations of cell stress.
Cellular senescence is a stable cell cycle arrest that is the causative process of aging.
Cellular senescence is a stable state of proliferative arrest that provides a barrier against malignant transformation and contributes to the antitumor activity of certain chemotherapies.
\ "Cellular senescence \ " is a state in which cells undergo irreversible cell cycle arrest in response to a variety of cellular stresses.
Cellular senescence is a state of irreversible cell cycle arrest induced by different types of cellular stresses.
Cellular senescence is a state of permanent cell cycle arrest , which has been shown to prevent neoplastic transformation.
Cellular senescence is a state of stable proliferation arrest of cells.
Cellular senescence is a stress response that accompanies stable exit from the cell cycle.
Cellular senescence is a terminal differentiation state that has been proposed to have a role in both tumour suppression and ageing.
Cellular senescence is characterized by cellular hypertrophy : cell growth in the absence of cell division.
Cellular senescence is defined as an irreversible growth arrest with the acquisition of a distinctive secretome.
Cellular senescence is described to be a consequence of telomere erosion during the replicative life span of primary human cells.
Cellular senescence is emerging as a key mechanism of age-related vascular endothelial dysfunction , but evidence in healthy humans is lacking.
Cellular senescence is implicated in normal ageing , tumour suppression , tumourigenesis , chronic diseases and more recently , in embryogenesis.
Cellular senescence is implicated in several pathological responses in the adult , with important repercussions in tumor suppression , wound healing , and aging.
Cellular senescence is now recognized as one of the nine hallmarks of ageing.
Cellular senescence is one of the hallmarks of aging , and contributes to the pathogenesis of age-related diseases.
Cellular senescence is the irreversible loss of proliferative potential and is accompanied by a number of phenotypic changes.
Cellular senescence is the permanent arrest of cell cycle , physiologically related to aging and aging-associated diseases.
Cellular senescence is the state of permanent inhibition of cell proliferation.
Cellular senescence is thought to play a major role in age-related diseases , which cause nearly @percent@ of all human deaths worldwide.
Cellular senescence is viewed as a mechanism to restrict excessive cell growth when it is unnecessary or harmful.
Cellular senescence may be a possible therapeutic target for these comorbidities.
Cellular senescence , mediated by telomere attrition , is in a class by itself , having recently been validated as a primary regulator of aging.
Cellular senescence , mediated by telomere attrition , is in a class by itself , having recently been validated as a primary regulator of aging.
Cellular senescence occurs as a response to extracellular and intracellular stresses and contributes to aging and age-related pathologies.
Cellular senescence plays important roles in the aging process of complex organisms , in response to stress and in tumor suppression.
Cellular senescence plays important roles in tissue repair or remodeling , as well as embryonic development.
Cellular senescence refers to the irreversible growth arrest of normally dividing cells in response to various types of stress.
Cellular senescence was analyzed by immunohistochemistry , senescent-associated β-galactosidase activity assay , Sudan black B staining , conventional transmission electron microscopy , and immunoelectronmicroscopy.
Cellular senescence was associated closely with IgAN disease progression , which suggested the accelerated senescence of RTECs may contribute to this progression.
Cellular senescence was checked by beta-galactosidase staining.
Cellular senescence was evaluated by senescence-associated β-galactosidase ( SA-β-gal ) staining and an immunohistochemical analysis of p21 and p16 protein expression.
Cellular senescence , which is believed to be associated with dysfunctional ( shortened ) telomeres , may contribute to the aging of a whole organism.
Cellular stress increases progressively with aging in mammalian tissues.
Cellular stress response is a reaction to changes or fluctuations of extracellular conditions that damage the structure and function of macromolecules.
Cellular therapies have the potential to impact recovery and tissue / organ regeneration for both early and late complications of radiation exposure.
Cell viability decreased in a concentration-dependent manner and the IC50 was determined as @number@ μM in MCF-7 and @number@ μM in Hs578T cell.
Cell viability decrease was correlated to an increase in cell apoptosis indicated by caspase- @date@ activities in the same spectral range.
Cell viability was determined by MTT assay and real time PCR was used to investigate apoptosis and telomerase genes expression.
Cell viability was measured using three different methods.
Cell yield and viability were quantified after isolation procedures , and expansion properties were assessed using assays for proliferation , senescence , and colony formation.
Cement leakage was observed in @number@ vertebrae ( @percent@ ) .
Cementless femoral fixation in total hip arthroplasty is dependent on mechanical and biological factors that affect implant stability and long-term outcome.
CENP-A deficiency in β cells leads to impaired adaptive proliferation in response to pregnancy , acute and chronic insulin resistance , and aging in mice.
CENP-A deposition at the centromere is augmented by PLK1 to promote mitosis , while knocking down CENP-A limits β cell proliferation and survival.
CENP-A is essentially undetectable after age @number@ in humans.
Censored patients ' vital status ( whether alive or dead ) were cross checked with the National Registration Department.
Census data show that the geriatric population is expected to grow to nearly @percent@.
Census-linked mortality data were collected by a recent project comparing health inequalities between European countries ( the EURO-GBD-SE project ) .
Census @number@ zip code level demographics and poverty rates were matched to study facilities.
Census reports of many countries indicate continuing trends for the graying of their populations.
Centenarians and their offspring are increasingly considered a useful model to study and characterize the mechanisms underlying healthy aging and longevity.
Centenarians are a model to study human longevity and the physiological process of aging.
Centenarians are rare and exceptional individuals characterized by a peculiar phenotype.
Centenarians are the best example of successful aging in humans , as they escaped from , or largely postponed , major age-related diseases.
Centenarians delay age-related methylation changes , and they can pass this methylation preservation ability on to their offspring.
Centenarians had the highest ApoE levels and the lowest frequency of APOE ε4 allele relative to younger groups.
Centenarians have been reported to share particular personality traits including low neuroticism and high extraversion and conscientiousness.
Centenarians have been used as an optimal model for successful ageing.
Centenarians not only enjoy an extraordinary aging , but also show a compression of morbidity.
Centenarians represent a rapidly growing population.
Center of foot-pressure average displacement ( root mean square [ RMS ] ; in millimeters ) was calculated.
Center of foot pressure displacements and frequency analysis were compared between the groups.
Center of pressure displacement ( CoP ) and velocity ( VCoP ) in the anterio-posterior ( AP ) and ML directions were analyzed.
Centers and associations within the community have gradually become the major infrastructures to provide old age service and support in China.
Centiles for AMH were estimated according to the exponential normal 3-parameter model.
Central adaptive processes change across the lifespan , showing increasingly less focal activation in older adults during repetitive grasping.
Central ( aortic ) blood pressure , arterial stiffness , and sympathetic nerve activity increase with age in women.
Central arterial stiffness , a hallmark of vascular aging , is associated with accelerated brain aging and cognitive decline.
Central arterial stiffness was assessed by carotid-femoral pulse wave velocity ( cfPWV ) .
Central atrophy correlated with aging and immediate memory ( p = 0.0294 ) : the higher the immediate memory , the lower the central atrophy.
Central auditory processing dysfunction may explain some understanding difficulties in elderly.
Central BP can be measured noninvasively using various techniques , including the convenient cuff-based oscillometric central BP monitors.
Central command and peripheral neural reflex are important neural control mechanisms underlying ventilatory response during exercise.
Central endothelium from young donors consistently showed a low level of positive staining.
Central hemodynamics was represented by central pulse pressure ( cPP ) .
Central ( hypogonadotropic ) hypogonadism in women could also be a cause of persistent amenorrhea and hypoestrogenemia.
Centrally located association fibers of the external capsule had higher FA and lower RD than the more peripherally-located superior longitudinal fasciculus ( SLF ) .
Centrally positioned trabeculae reinforce the thin cortex and transfer loads from the joint to the proximal thicker cortical bone.
Central measures include physical activity , a healthy diet and intervention in risk factors - early enough , of course.
Central nervous system networks are effectively maintained through aging by neuroprotective and neuroplasticity signaling mechanisms which are predominantly controlled by neurotrophin receptor signaling.
Central obesity , in particular , results in several adverse metabolic consequences , including dysglycemia , dyslipidemia , hypertension , and cardiovascular disease.
Central PP was more strongly related to arterial stiffness and vascular damage markers than the other pressure indices.
Central pressure is influenced by the phenomenon of arterial wave reflections returning from the peripheral vasculature , which can be quantified by augmentation index.
Central pulse wave velocity did not significantly increase in any age group after exercise when compared to the control condition.
Central regulation of metabolic physiology is mediated critically through neuronal functions ; however , whether astrocytes are also essential remains unclear.
Central Retinal Artery and Vein Equivalents ( CRVE and CRAE ) were measured.
Central sensor of the regulation is kinase mTOR.
Central systolic and diastolic pressures were also worse over time by addictive status ( P < 0·005 ) .
Central to application of this model is the concept of \ "pre-osteoarthritis , \ " conditions where clinical OA has not yet developed.
Central to the Center is a cohort study of randomly selected university employees.
Central to the model was a simulated neural controller that multiplied time-delayed kinematics by invariant feedback gains.
Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative diseases.
Central to this multifactorial process is the increase in oxidative stress levels , which correlates with age-related disease pathogenesis in animal models and in humans.
Central to this perspective is the intertwining of religion and spirituality in Islam.
Central to understanding HSDD is the impact of aging female sexual endocrinology and its effect on both prevalence and expression patterns of FSD.
Centre-based assessments facilitate detailed measurements and novel technologies , but may differentially influence participation.
Centrioles are essential for ciliogenesis.
Centrosome aberrations and changes in stem cell numbers were examined to assess cancer susceptibility.
CEP promoted angiogenesis in hindlimb ischaemia and wound healing models through MyD88-dependent TLR2 signalling.
Ceramides favor anti-proliferative and cell death pathways such as senescence and apoptosis , whereas S1P stimulates cell proliferation and survival pathways.
Cer and DAG , two fusogenic intermediates , modify the membrane lipid bilayer for the initiation of vesicle formation and transport.
Cereals enriched with tryptophan may be useful as a chrononutrition tool for alterations in the sleep / wake cycle due to age.
Cerebellar and extracerebellar symptoms were graded according to degree of functional impairment.
Cerebellar cortical tissue from @number@ cases with essential tremor and @number@ age-matched control subjects was processed by the Golgi-Kopsch method.
Cerebellar morphology and function have been implicated in a variety of developmental disorders , and in healthy aging.
Cerebellar morphology is often as good as - or even better - at predicting performance than the prefrontal cortex.
Cerebellar mutism , psychological and social issues.
Cerebellar postural changes may be predictive of the increased risk of falls in older PM males.
Cerebral activity was recorded using electroencephalograph in young and older individuals performing a spatial memory task that required the creation of cognitive maps.
Cerebral amyloid angiopathy ( CAA ) is cerebrovascular amyloid deposition.
Cerebral amyloid angiopathy ( CAA ) , the deposition of amyloid-β in cerebrovascular walls , is the most common cause of lobar hemorrhagic stroke.
Cerebral amyloid angiopathy ( CAA ) was an independent predictor for recurrent ICH ( HR , @time@ ; @percent@ CI , @number@.80-211.47 ) .
Cerebral arteries on the brain base of @number@ adult cadavers of both genders and varying age and causes of death were dissected.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ( CADASIL ) is caused by mutations in the NOTCH3 gene on chromosome @number@
Cerebral Aβ levels build from preclinical through early dementia stages followed by hyperphosphorylated tau-related pathology , the latter driving cognitive deficits and dementia severity.
Cerebral blood flow ( CBF ) , cerebrovascular reserve capacity ( CVRC ) , and hemodynamic stress distribution were calculated.
Cerebral blood flow is inhibited by tortuous arterioles and deposition of excessive collagen in veins and venules.
Cerebral cavernous malformations ( CCMs ) are vascular abnormalities that may cause seizures , intracerebral haemorrhages , and focal neurological deficits.
Cerebral dysfunction after cardiac surgery remains a devastating complication and is growing in importance with our aging populations.
Cerebral HCAR1 is concentrated on the postsynaptic membranes of excitatory synapses and also is enriched at the blood-brain barrier.
Cerebral hemispheres were obtained from @number@ deceased older adults.
Cerebral herniation and diffuse cerebral edema due to vascular endothelial dysfunction were concluded to be the cause of death.
Cerebral ischemia caused by loss of blood supply to the brain during cardiac arrest or stroke are major causes of death and disability.
Cerebral levels of BACE1 are elevated in individuals with AD , but the molecular mechanisms are not completely understood.
Cerebral microbleeds ( CMBs ) are considered to be a novel marker of cerebral small vessel disease.
Cerebral microinfarcts ( CMIs ) are a common finding in neuropathological studies of aging and dementia.
Cerebral microinfarcts ( CMIs ) are common neuropathologic findings in aging and dementia.
Cerebral myelin maturation and aging-related degradation constitute fundamental features of human brain integrity and functioning.
Cerebral oxygenation-perfusion ( exercise ) was related to cognitive function ( P < 0.005 ) .
Cerebral perfusion can be compromised as result of obesity , cerebrovascular disease , hypertension , or diabetes mellitus type @number@
Cerebral perfusion is important in older adults as it is linked to cognitive declines.
Cerebral perfusion seems to be most vulnerable to myocardial ischemia in elderly with nocturnal blood pressure dipping.
Cerebral small vessel disease ( SVD ) is a common accompaniment of ageing.
Cerebral small vessel disease ( SVD ) is a prevalent , neurological disease that significantly increases the risk of stroke and dementia.
Cerebral SVD were independently assessed by @number@ raters who were unaware of the CAC scores.
Cerebral vascular diseases and initial stages of neurodegenerative processes are the cause of MCI.
Cerebral venous outflow insufficiency via the internal jugular vein ( IJV ) is associated with several neurological disorders.
Cerebral vessel flows are affected by age and cerebrovascular anatomy , which has important implications for interpretation of flows in the disease state.
Cerebral white matter hyperintensities ( WMH ) and conditions affecting other systems are known contributors , but have been studied in isolation.
Cerebral white matter hyperintensities ( WMHs ) are central MRI markers of the brain aging process , but the mechanisms for its progression remain unclear.
Cerebral white matter lesions ( WML ) are common in the aging brain and are associated with dementia and depression.
Cerebral white matter lesions ( WMLs ) are related to cognitive deficits , probably due to a disruption of frontal-subcortical circuits.
Cerebral β-amyloid ( Aβ ) deposition and atrophy are central features of Alzheimer disease.
Cerebrolysin as a therapeutic agent should be considered by clinicians seeking treatment options for mild-to-moderate AD.
Cerebrospinal fluid analysis and other monitoring tools may in the future provide reliable measurement of soluble load.
Cerebrospinal fluid ( CSF ) analysis revealed a normal cell count , with significantly elevated levels of 14-3-3 protein and total tau protein.
Cerebrospinal fluid ( CSF ) examination indicated a diagnosis of aseptic meningitis and revealed high levels of Q albumin and IgG index.
Cerebrospinal fluid ( CSF ) levels of adenosine deaminase ( ADA ) remarkably elevated.
Cerebrospinal fluid ( CSF ) neurofilament light ( NFL ) is a marker of axonal degeneration.
Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation.
Cerebrovascular CO2 reactivity was tested with hyperventilation and CO2 inhalation.
Cerebrovascular complications was developed in @number@ patients and @number@ of the @number@ patients died from hemorrhagic infarction.
Cerebrovascular disease , a preventable condition , was specifically associated with bradykinesia.
Cerebrovascular disease , cirrhosis , asthma , and diabetes mellitus are important contributors to cognitive deterioration in the elderly.
Cerebrovascular disease constitutes one of the main causes of morbidity , disability and mortality worldwide.
Cerebrovascular disease ( CVD ) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment.
Cerebrovascular disease ( CVD ) is the second leading cause of cognitive impairment in late life.
Cerebrovascular disease has long been the leading cause of death in Portugal.
Cerebrovascular disease was a common secondary cause.
Cerebrovascular disease was the most frequent diagnosis in these patients ( @percent@ ) .
Cerebrovascular dysfunction is rapidly reemerging as a major process of Alzheimer's disease ( AD ) .
Cerebrovascular function was assessed using the transcranial Doppler ultrasound.
Cerebrovascular health is important for maintaining a high level of cognitive performance , not only in old age , but also throughout the lifespan.
Cerebrovascular risk factors included blood pressure , cholesterol , body mass index , creatinine , and diabetes-related factors.
Cerebrovascular risk factors , medications , and blood-pressure parameters were also reviewed.
Cerebroventricular infusion of Aβ1-40 enhances BK release , suggesting that the activity of this system may be elevated in AD.
Certain aetiologies , including diabetes , are difficult to treat with current modalities , emphasizing the need for new molecular targets.
Certain aspects of aging changes mimic accommodation.
Certain aspects of social integration can moderate marital status-gender differences in depressive symptoms among older Mexicans.
Certain authors report negative correlation between Mt production and blood cholesterol level.
Certain cell populations in specific brain regions are more susceptible to age-related changes that initiate regional and system-level dysfunction.
Certain cellular proteins normally soluble in the living organism under certain conditions form aggregates with a specific cross-β sheet structure called amyloid.
Certain essential trace minerals have shown to play an important role in the maintenance of redox homeostasis.
Certain gene polymorphisms are associated with human aging.
Certain groups should be targeted to reduce sitting time , for example those with higher educational attainment and obese females.
Certain heritable disorders of connective tissue , which have a unifying symptom of joint hypermobility , are caused by mutations within the COL5A1 gene.
Certain indices can be affected by age and gender.
Certainly , 5-HT6 drugs modulate memory , which are accompanied with neural changes.
Certainly , biological processes that correlate with aging occur earlier in the older adult HIV population.
Certain models of compliant flooring have been shown to have limited influence on postural sway and successful completion of dynamic balance tasks.
Certain photosynthetic marine organisms have evolved mechanisms to counteract UV-radiation by synthesizing UV-absorbing compounds , such as mycosporine-like amino acids ( MAAs ) .
Certain small Rho-GTPases are involved in synaptic plasticity , and their dysfunction is associated with brain aging and neurodegeneration.
Certain toxicities from systemic treatments can be more pronounced and should be carefully managed.
Certain woody and fruity volatiles varied significantly ( p < @number@ ) depending on whether MLF occurred in barrels or tanks.
Cervical cancer accounts for the second most frequent cancer and also third leading cause of cancer mortality ( @percent@ ) among women worldwide.
Cervical cancer is one of the most frequent cancers in women worldwide.
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide.
Cervical epithelial type should be measured in clinical studies involving cervicovaginal immune markers.
Cervical epithelial types were viewed on colpophotography and measured quantitatively using computerized planimetry.
Cervical Intraepithelial Neoplasia grade @number@ or worse ( CIN2 + ) was detected in @number@ women ( @percent@ ) .
Cervical Intraepithelial Neoplasia grade @number@ or worse ( CIN2 + ) was detected in @number@ women ( @percent@ ) .
Cervical NF is quite rare , is mostly of odontogenic origin , and may be complicated by descendant mediastinitis with a very high mortality rate.
Cervical samples were collected from each participant and HPV screening was conducted using microarray hybridization.
Cervical spine ligaments have an important role in providing spinal cord stability and restricting excessive movements.
Cervical spondylosis can be identified in the majority of people older than @number@ years.
Cervical spondylosis is a disorder for age-related wear affecting the disks and vertebrae of cervical spine.
Cervicovaginal cytokines were adjusted to total protein concentration [ pg / mcg protein ] .
CES1 protein abundance in liver cytosol also showed age-dependent maturation.
CES-D correlations were @number@ ( @percent@ CI @number@ @date@ ) for MZ twins and @number@ ( @percent@ CI @number@ @date@ ) for DZ twins.
CES-D scores correlated with CSF HNE levels only in Control and HIV groups , but not in Meth and HIV + Meth groups.
CES-D was log-transformed ( CES-D ( log ) ) for analyses.
Cetyltrimethylammonium bromide as the coating material showed more significant activation of neutrophils than soyaethyl morpholinium ethosulfate.
Cetyltrimethylammonium bromide ( CTAB ) or soyaethyl morpholinium ethosulfate ( SME ) was incorporated into liposomes as the cationic additive.
CEUS also improved the delineation of the lumen , and was reliable in showing its patency degree and integrity of walls.
CFA assessed the stability of the factor structure itself.
CFC followed a similar pattern , with strongest age-related modulation of 40-Hz amplitude by the phase of delta oscillations.
CF copy did not show any significant associations with HV.
CfPWVcalip , measured in @number@ patients , underestimated aoPWVinv in all ages.
C-f PWV was measured with the help of SphygmoCor.
CF-PWV was significantly higher in patients with an IADSBP ≥10 mm Hg ( @number@.3±1.9 vs @number@.2±2 , P = .002 ) .
CFR can be used as a new model in gerontology providing increased life when transferred on a diet not only young but also old animals.
CF-related diabetes affects @percent@ of adult CF patients.
CFR is also affected by atherosclerotic risk factors and left ventricular hypertrophy.
CFR was calculated as the ratio between hyperemic and resting coronary diastolic peak velocities.
CFR was progressively reduced with aging ( 1st quartile : @number@ ± @number@ 4th quartile : @number@ ± @number@ p < @number@ ) .
CFTR may be a pontential target for rescuing sperm motility as well as a fertility indicator in old age men.
CGA can have important positive impacts on the health of older people , but it is labor-intensive and costly.
CGA in ED is efficient for decreasing functional decline , ED readmission and possibly nursing home admission in high-risk patients.
CGA is the best tool for determining the health status of an older patient.
CGA leads to an increase in polypharmacy , mainly because of new conditions being diagnosed and despite frequent discontinuation of medications.
CGA probably leads to slightly reduced length of stay ( @number@ trials , @number@ participants , moderate-certainty evidence ) .
CGAs differ across healthcare settings , ranging from shared care conducted in primary care settings to specialized inpatient units in acute care.
CG met once a week for health education meetings.
CGMP in turn increases Ca2 + uptake into intracellular calcium stores thereby lowering [ Ca2 + ] i and inducing VSMC relaxation and vasodilation.
CG subjects received a placebo vibratory stimulation.
CG underwent sham vibratory treatment.
CGβ subunits comprise a unique carboxyl-terminal peptide ( CTP ) that has multiple O-linked glycans and extends serum half-life of the protein.
Chair-rise time decreased by @number@ ± @number@ seconds ( range : @number@ to @number@ seconds ; P = @number@ ) from @number@ to @number@ weeks.
Chair stand and walking performance ( P < @number@ ) , but not balance , were lower in participants with OA.
Chair stand ( p = @number@ ) and straight walking test ( p < @number@ ) were significantly improved.
Challenges associated with providing care may bias the caregiver's recognition and reporting of symptoms.
Challenges for future research include further validation of existing prediction tools and evaluation of the cost-effectiveness of treatment after screening.
Challenges for the development of phytochemicals as drugs and for quality control of standardized plant extracts are also considered.
Challenges on the social field must be focussed on ageism.
Challenges to culture change implementation include the wide range of possible interventions as well as a lack of research-based evidence to guide these choices.
Challenges to pharmacological management in this patient group include treatment concordance , comorbidity , polypharmacy , and age-related physiological changes affecting pharmacokinetics.
Challenging this notion , two new studies show that somatic mosaicism is common and can be an early herald of cancer.
Chambers of adipocytes in the hypodermis were separated by thin fibroseptations : a scaffold in the structural support of this region.
Champaign , IL : Human Kinetics. ) .
CH and ACV were significantly lower in HE compared to HY.
Changed with age anterior commissure ' Broyles ligament by the process of neovascularization and ossification is not an effective protection against the spread of cancer.
Change in biomedical factors and employment did not amend the explanation.
Change in BMD was determined from mixed effects regression models taking age and weight into account.
Change in facility fall rates was an exploratory outcome.
Change in functional impairment progressed slowly in the early disease groups , but showed an accelerated worsening in those converting to dementia.
Change in immunization rates from baseline to year @number@ were compared between those participating in the collaborative training and those not participating.
Change in inflammatory response was assessed by administering an oral lipid tolerance before and after the treatment of uric acid , rasburicase and placebo.
Change in ovarian biomarkers did not mediate the time to FMP.
Change in PA and sitting time were calculated as the difference between the cumulative average immediately following MI and the cumulative average immediately preceding MI.
Change in PA was calculated from Physical Activity Scale for the Elderly ( PASE ) as PASE T4-PASE T1.
Change in perceived control was associated with change in neuroticism and conscientiousness , pointing to particular adaptation mechanisms specific to old age.
Change in the cell-mediated inflammatory response impacts on gingival and periodontal disease manifestation and progression.
Change in the Mini-Mental State Examination at the first and second follow-ups ( mean = @number@ and @number@ respectively ) was negligible.
Change in working memory and attention were not associated with plasma homocysteine , folate or B12.
Change management in implementing ICT enabled integrated care ; @number@
Change of expression of tubulin beta-3 chain was confirmed by western blot on samples originated from several donors.
Change of orotracheal intubation difficulty was checked retrospectively.
Change on continuous measures and categorical outcomes were compared across older vs. younger patients.
Change point analyses identified a significant decrease in dementia incidence among those born after @date@ ( @percent@ CI , @date@ to @date@ ) .
Change point models are used to describe processes over time that show a change in direction.
Change point models can be extended by adding random effects to account for variability between subjects.
Change points were then assessed separately for high- and low-education groups.
Changes associated with aging such as wrinkled skin or weight gain often bring women further from societal ideals of attractiveness.
Changes due to these alterations are often hard to evaluate in detail when whole gut samples are used.
Changes during senescence can significantly affect both the emotional and relational needs of old individuals and the characteristics of the attachment system.
Changes from baseline at week @number@ in mean SeBP were similar to 24-hour ambulatory BP changes reported previously.
Changes from baseline in the rivastigmine versus placebo groups were evaluated using the van Elteren test blocking for country.
Changes from baseline to efficacy endpoint and differences in changes between treatment groups were estimated as least-squares means using analysis of covariance models.
Changes from Wave @number@ to @number@ revealed @number@.5%-25.2% of individuals reported better health and @number@.3%-44.7% reported worse health.
Changes in acetyl histone levels were proportional to changes in total histone levels.
Changes in AER and GFR are being increasingly recognized as complementary rather than obligatory manifestations of diabetic CKD.
Changes in AHEI-2010 over @number@ years were not associated with AAC severity.
Changes in arterial compliance had little impact on changes in Ea , but were strongly associated with changes in Ees.
Changes in astroglia in aging and neurodegeneration are highly heterogeneous and region-specific.
Changes in attitudes toward urinary incontinence showed statistical significance ( p < @number@ ) .
Changes in bed supply due to closures were examined at various geographic levels.
Changes in behavior may represent the earliest indications of medical problems , or disorders of the central nervous system , and these may be bidirectional.
Changes in BMI were analyzed using hierarchical linear modeling with time-constant and time-varying covariates.
Changes in body composition , i.e. , reduction in fat mass and gain in lean body mass improved the blood lipid profile.
Changes in body composition , including a decrease in muscle and bone mass , accompany aging.
Changes in body composition occur as part of the normal ageing process and are associated with important effects on health and function.
Changes in body composition occurring with advancing age , reduced liver mass and perfusion , and reduced renal excretion may affect either pharmacokinetics or pharmacodynamics.
Changes in body mass index and skinfold thickness were estimated through height , weight , and anthropometric measurements.
Changes in body weight can affect the overall health of an older patient and should not be considered a normal part of the aging process.
Changes in bone metabolism after WBVAT treatment were not observed in most cases.
Changes in bone properties due to altered metabolism are sensitively revealed in trabecular bone.
Changes in brain-derived neurotrophic factor ( BDNF ) level are implicated in the pathophysiology of cognitive decline in depression and neurodegenerative disorders in older adults.
Changes in carotid-femoral and femoral-tibialis posterior PWV correlated significantly with their respective baseline values.
Changes in cartilage and subchondral bone are not merely secondary manifestations of OA but are active components of the disease , contributing to its severity.
Changes in CBF through the major cerebropetal arteries were assessed via phase contrast MR-angiography , and regional cortical tissue perfusion via pseudo-continuous arterial spin labelling.
Changes in CD200 and ICAM-1 levels did not correlate with LB pathology , but with AD pathology.
Changes in cellular senescence and the linked changes in telomere length might be potential markers of age-related sleep changes.
Changes in checkpoint inhibitory molecules / pathways during aging may be one mechanism that impairs the ability of elderly DCs to activate T cells.
Changes in chromatin that occur during the aging process are poorly documented and understood in higher organisms , such as mammals.
Changes in cognitive functioning are said to be part of normal aging.
Changes in cognitive state , daily functioning , quality of life , constipation , and other adverse events were assessed.
Changes in collection protocol and labs between waves may have yielded small systematic differences that require analysts to carefully interpret absolute HbA1C values.
Changes in cut-off points for gait speed and grip strength had a limited impact on sarcopenia prevalence and on study comparability.
Changes in cytoprotective signaling may influence cardiac aging , and underpin sensitization to ischemic insult and desensitization to ' anti-ischemic ' therapies.
Changes in DNA methylation in nontarget tissues , specifically peripheral blood , can also affect risk of malignant disease.
Changes in EEG time and frequency domains were described.
Changes in either neurological or cognitive examination in older adults should be considered abnormal and due to underlying disease.
Changes in endogenous estrogen levels during the menstrual cycle likely contribute to the broad inter-individual variation in PCSK9 and LDL-C in normal females.
Changes in epigenetic programming of embryonic growth genes during pregnancy seem to affect fetal growth.
Changes in ERG properties were found in the oldest age group when compared with the two younger age groups.
Changes in fat distribution related to aging and reproduction may contribute to the life-course development of cardiovascular risk.
Changes in fat mass , bone mass and serum bone markers did not significantly differ between the groups ( p > 0.05 ) .
Changes in fat structures in the face cause aesthetic changes that can be addressed surgically.
Changes in FM and leptin accounted for @percent@ of the variance in ΔREE ( P = @number@ ) .
Changes in FoxO expression and activation may be involved in cartilage aging and OA.
Changes in fructose malabsorption with age have been observed in human infants , and this may parallel the developmental regulation of GLUT5 expression.
Changes in gait speed and energy level were significantly associated with changes in GDS scores over time.
Changes in gait speed and grip strength had a limited impact on sarcopenia prevalence.
Changes in gait speed were very small and unlikely to be of clinical relevance.
Changes in gene expression in the brain may underlie cognitive deficits inherent to normal aging and neurodegenerative disease.
Changes in gray matter were assessed using voxel-based morphometry and gray matter volumetric analysis.
Changes in HbA1c from baseline were evaluated with an analysis of covariance model.
Changes in health care and government health policies may influence the death locations , making it possible to remain at home or in an institution.
Changes in health status were related to changes in some aspects of processing speed.
Changes in health utility over time are captured as a result of complications and aging.
Changes in hematological and serum chemistry values have been identified among older compared to younger humans.
Changes in ∆ [ HHb ] of the vastus lateralis muscle were measured by near-infrared spectroscopy.
Changes in hormonal , neuronal , and biochemical cues with age and their effect on bone have been discussed.
Changes in image were investigated as mean differences of the total and concept scores.
Changes in insulin resistance explained ∼17% of changes in composite z score ( partial r² = @number@ P < @number@ ) .
Changes in intima-media thickness or calcium scores were not associated with change in testosterone levels among individuals assigned to receive testosterone.
Changes in intramyocellular lipid content correlated with changes in body fat content with both RET and EET.
Changes in LBM and hand grip strength were not significant or clinically meaningful.
Changes in LC can elicit different clinical outcomes.
Changes in LTPA from @number@ to @number@ were linked to all-cause mortality from @number@ to @number@
Changes in lumbar lordosis were concentrated in the lower lumbar region in the older group in sitting positions.
Changes in maximal isometric and dynamic muscle strength were similar between OM and YM.
Changes in mechanical properties are an essential characteristic of the aging process of human skin.
Changes in metabolites by UPLC-LTQ-Orbitrap mass spectrometry and changes in brachial-ankle pulse wave velocity ( ba-PWV ) were examined.
Changes in microglia function are involved in Alzheimer's disease ( AD ) for which ageing is the major risk factor.
Changes in mitochondrial capacity and quality play a critical role in skeletal and cardiac muscle dysfunction.
Changes in ML control strategies over time suggests that fatigue could affect prolonged stooping more so than crouching or standing.
Changes in mRNA levels due to a single exposure were transient and decreased @number@ days after exposure.
Changes in muscarinic receptor functions have been demonstrated with aging and in different disorders associated with OAB / DO.
Changes in myosin content appear to occur independently of age , while influenced by fiber type ( MHC isoform ) in young but not old.
Changes in nutrient supply require global metabolic reprogramming to optimize the utilization of the nutrients.
Changes in one-repetition maximum strength were associated with increases in stair climbing power ( r = @number@ p = @number@ ) .
Changes in oxidative stress are also associated with the natural aging process.
Changes in oxyhemoglobin concentrations in the cerebral cortex during memory and calculation tasks were measured.
Changes in oxy-hemoglobin were measured in the prefrontal area during gait experiments.
Changes in parenthood , marital , and employment status were associated with persistence , new onset , and recurrence.
Changes in pathogen levels observed throughout manufacture and aging did not significantly differ by cheese type.
Changes in patient case mix , work place support systems and individual adjustments can assist safe practice.
Changes in pensions , income inequity , and education were significantly associated with work expectations , but SSA policy was not.
Changes in personality and judgment in dementia raise both practical and philosophic problems concerning personal identity.
Changes in pharmacodynamics and pharmacokinetics induced by aging make elderly patients very sensitive to drugs , especially those administered perioperatively.
Changes in pharmacokinetics and pharmacodynamics of benzodiazepines ( BZDs ) during ageing may increase their potential to cause adverse outcomes.
Changes in phasic atrial volumes develop earlier consequent to age-related alteration in LV diastolic relaxation.
Changes in physical activity were classified as inactive , decreaser , increaser , or active.
Changes in population doubling time and beta-galactosidase activity were used as indexes of aging and compared with other cellular parameters.
Changes in protein intake were evaluated using paired t-tests.
Changes in protein turnover are among the dominant metabolic changes during aging.
Changes in regional activity levels and network connectivity occur across the lifespan within the default mode network ( DMN ) of resting brain function.
Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events.
Changes in RyR isoform expression and alternative splicing have not been examined for potential roles in AD pathogenesis.
Changes in satellite cell content play a key role in regulating skeletal muscle growth and atrophy.
Changes in SBP negatively correlated with changes in NO ( r = @number@ P = @number@ ) .
Changes in sex hormone levels with aging or illness may lead to metabolic disorders.
Changes in situational features , such as changes in characters , goals , and objects predicted segmentation.
Changes in skin elasticity , wrinkling , sagging , and yellowness seem to be caused by additional extrinsic ageing.
Changes in skin mechanics improved cutaneous thresholds in the oldest males after moisturizing ( p = @number@ ) but not otherwise.
Changes in skin with age include decline in thickness and composition , a decrease in the number of most cell types , and diminished microcirculation.
Changes in SkM HSP70 inversely correlated with insulin and homeostasis model assessment trajectories such that a positive change in SkM level was beneficial.
Changes in social interactions with owners and other dogs are frequently observed in dogs with cognitive dysfunction syndrome ( CDS ) .
Changes in somatic and germ-line DNA and epigenetics are reported to play large roles in accelerating the onset of human diseases.
Changes in SRTn were calculated as a raw shift ( T1 - T0 ) and an adjusted shift for regression towards the mean.
Changes in staff knowledge of the assessment and treatment of urinary incontinence did not reach statistical significance.
Changes in strength , power , and FFM are predictors of ST-induced improvements in these tasks.
Changes in subsistence strategy have caused some of the profoundest changes to the structure and health of humans.
Changes in swallowing function caused by aging alone are termed presbyphagia.
Changes in target protein expression were determined by Western blot analysis.
Changes in target speaker were either unpredictable or semantically cued by a word within the target stream.
Changes in task performance that accompany healthy aging are often attributed to age-impaired inhibitory control.
Changes in technology offer the opportunity for e-health promotion as a means of educating populations and healthcare staff to meet public health targets.
Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing.
Changes in the aging immune system influence the cellular composition and function in asthmatic airways.
Changes in the axis are associated with changes in other hormonal axes , specifically the adrenal androgen and the somatotropic axis.
Changes in the DNA information content through mutation generate diversity for evolution through natural selection but are also a source of deleterious effects.
Changes in the effects of birth length and maternal weight on diabetes risk with age may indicate different causal pathways.
Changes in the facial skeleton that occur with aging and their impact on facial appearance have not been well appreciated.
Changes in the FI characterize the rate of individual aging.
Changes in the levels of observed analytes in each decade across the age spectrum were evaluated.
Changes in the modern diet include excessive nutrient-bound AGEs , such as neurotoxic methyl-glyoxal derivatives ( MG ) .
Changes in the morphology of dermal collagen may indicate aging or pathological processes.
Changes in the mRNA expression of @number@ genes coding tight junction proteins , transporters and enzymes were observed in methylglyoxal-treated hCMEC / D3 cells.
Changes in the nonspecific , i.e. innate immunity are not as strong as in the acquired , adaptive immunity.
Changes in the number of RA deaths between @number@ and @number@ were decomposed using @number@ counterfactual scenarios.
Changes in the osteocyte distribution and in their elemental composition might be involved in age-related bone impairment.
Changes in the outcome measures between control and treatment periods were compared.
Changes in the population prevalence of obesity and smoking were associated with period and cohort trends in pre-eclampsia but did not explain the trends.
Changes in the population size and structure will be responsible for most of the increase.
Changes in the protein and mRNA levels of BAX and DRAM1 and the role of DRAM1 in BAX induction were determined.
Changes in the ratio of penile collagen have also been observed and could explain the decrease in penile elasticity and compliance with aging.
Changes in the recommended dosing of NSAIDs could not be determined due to low numbers of administered doses in both phases of the study.
Changes in the relationship between fat and bone also appear to be age and sex dependent.
Changes in these parameters during development correlated with age and gender.
Changes in the structure of the vocal fold ( VF ) can interfere with the voice.
Changes in the transcription profiles were evaluated using DNA microarray and real-time reverse-transcription PCR.
Changes in tissue composition and cellular architecture have been associated with neurological disease , and these in turn can affect biomechanical properties.
Changes in vascular function may partly underlie the observed associations between ambient temperature and risk of cerebrovascular events.
Changes in visual function beyond high-contrast acuity are known to take place during normal aging.
Changes in WEL scores partially mediated the effects of the WL + PA intervention on weight loss.
Changes in whole-body fuel metabolism could be related to alterations in arterial stiffness in ageing adults.
changes may be additive or synergistic with the effects produced by immunomodulatory and immunosuppressive medications.
Changes observed during IF are probably due to the changes in eating and sleeping pattern and thus changes in metabolic rhythm.
Changes occur in our body through out life.
Changes of between-network FC were also apparent , suggesting that regions maintaining connections to multiple networks may be particularly susceptible to Aβ-induced alterations.
Changes of brain metabolite levels after MPH were found not to be statistically significantly different between the subtypes.
Changes of intima media thickness , inflammatory and endothelial adhesion biomarkers levels , Veterans Aging Cohort Study index and Framingham risk score were evaluated.
Changes of mfMRI parameters were significantly associated with RPE in both cohorts.
Changes of the level and activity of several enzymes removing exocyclic adducts from the DNA was reported during carcinogenesis.
Changes of the microenvironment around the tryptophan residue ( Trp-214 ) of non-glycated and glycated proteins was investigated by the red-edge excitation shift method.
Changes of the peritoneal permeability seen during chronic PD in rats are comparable to results obtained in humans treated with PD.
Changes of this molecules expression level are the base of the social significant diseases as endometriosis , endometrial cancer and infertility.
Changes over @number@ years were reported for four measures common to both waves.
Changes that affect desired outcomes include aligning and understanding stakeholders ' motivations and behaviours as well as gaps in key processes.
Changes that occur during DNA repair , chromosome duplication , and transmission or via recombination provide a natural source of genetic variation.
Changes to haemodynamic parameters were also recorded.
Changes to skin mechanical properties were measured by ultrasound scanning and cutometry.
Changes to social and physical environments may facilitate healthy behaviors and minimize harmful exposures.
Changes to white matter and subcortical GM structures may be more relevant in explaining the underlying neurobiology of LLD.
Changes were assessed with Wilcoxon signed rank sum tests and McNemar's tests.
Changes were independent of baseline disease severity or psychological covariates.
Changes were small and nonsignificant in the controls ( p > @number@ ) .
Changes which affect their proliferate rate , differentiation capability and genome stability lead to decrease of their usefulness in new therapies.
Changes with age are noted in most components of the DMN , especially in medial frontal / anterior cingulate and posterior cingulate / precuneus regions.
Changes within normal-appearing white matter ( NAWM ) in subjects with WMH have also been reported but have not yet been fully characterized.
Change versus stability was examined using two methods : ( @number@ ) repeated-measures analyses and ( @number@ ) test-retest reliabilities of blood oxygenation level-dependent responses.
Changing demographics in Nigeria , in addition to cultural considerations and absence of a social security system , present unique challenges to elderly.
Changing global demography is resulting in older people presenting to emergency departments ( EDs ) in greater numbers than ever before.
Changing patterns of health care will result in changing demands for blood components.
Changing practice to meet escalating care demands in correction settings is complicated by economic constraints , attitudinal barriers , and organizational features.
Channels over auditory areas contributed more to this predictive sensory information than visual areas.
CHA ( @number@ ) DS ( @number@ ) -VASc score was not associated with major bleeding episodes.
Chaos and bios analyses may thus be useful in clinical studies.
Chaperone-mediated autophagy ( CMA ) is a multistep process that involves selective degradation and digestion of a pool of soluble cytosolic proteins in lysosomes.
Chaperones are central to the proteostasis network ( PN ) and safeguard the proteome from misfolding , aggregation , and proteotoxicity.
Chaperones are important players in the aging process as they prevent protein misfolding and aggregation.
Chappell and Hollander \ "offer an evidence-based policy prescription to meet the challenges … [ of ] an aging society. \ "
Chappell and Hollander provide support for a set of policy directives formulated for an aging population.
Character developed toward greater maturity , although self-transcendence decreased with age.
Characterisation of mechanisms that mediate VT formation and stability , particularly in aging , are needed to advance understanding of VT.
Characteristically , hypokinesis or akinesis occurs in the mid- and apical segments of the left ventricle in the absence of epicardial coronary lesions.
Characteristic changes in systemic iron handling , erythrocyte production , and erythrocyte life span all contribute to AI.
Characteristic ethnic features have been described in the literature , but as societies have changed , many of these ethnic variations have blended together.
Characteristic features were quantified by image analysis.
Characteristic of this change is the age-associated decline in skeletal muscle mass , sarcopenia.
Characteristic properties are proposed and requirements are derived from the available body of literature.
Characteristics between these two groups were compared.
Characteristics independently associated with functional decline were change in FOF , depressive symptoms , low frequency of meeting friends , and fear-induced activity avoidance.
Characteristics in ELBW neonates with raised peak Scr ( > P75 ) were compared to controls ( < P75 ) .
Characteristics of cholesterol metabolism were related to survival in a random @number@ + population sample.
Characteristics of chronological aging were compared among 6- , 24- and 28-month-old male Sprague-Dawley rats.
Characteristics of DISH ( ossifications between vertebral segments ) reflect changes of spine anatomy and physiology that may be associated with Cobb angle of kyphosis.
Characteristics of each type of intervention are described and discussed.
Characteristics of hearing loss level and its improvement , in UCLP children depend of cleft type , ear side and age group.
Characteristics of mood in the course of therapeutic correction correlated with dynamics of skin smoothness and elasticity.
Characteristics of participants with and without DISH were assessed using the χ² and t tests.
Characteristics of patients , including previous health status and functional dependence , were recorded on-the scene by the attending physician.
Characteristics of population might explain these results.
Characteristics of the events themselves were primarily unrelated to trait change.
Characteristics of the most recent fall were obtained through detailed interviews with study participants.
Characteristics were summarized descriptively.
Characterization of the evolution and outcome into adulthood has not been sufficiently investigated.
Characterization of the timing and nature of symptomatic dysfunction is important for understanding the impact of α-syn on disease progression.
Characterized by both motor and non-motor symptoms , PD patients classically display rest tremor , rigidity , bradykinesia , and stooping posture.
Characterizing brain changes in Alzheimer's disease ( AD ) is important for patient prognosis and for assessing brain deterioration in clinical trials.
Characterizing cognitive decline in the preclinical phase of AD is critical for the development of early intervention strategies when disease-modifying therapies may be most effective.
Characterizing effects of sex and age on RSNs are critical first steps in understanding the functional organization of the human brain.
Characterizing the nature of linguistic representations and how they emerge during early development is a central goal in the cognitive science of language.
Charcot-Marie-Tooth disease ( CMT ) is the most commonly inherited neurological disorder with a prevalence of @number@ in @number@ people worldwide.
Charcot-Marie-Tooth disease type 1A ( CMT1A ) is a hereditary demyelinating neuropathy linked with duplication of the peripheral myelin protein @number@ ( PMP22 ) gene.
CHARLS recruited a nationally representative community sample of households with members aged @number@ years or above.
Chart review is central to health services research.
Chart review was performed to obtain baseline characteristics.
Charts relating PNIF normal values in the elderly with various explanatory variables have been provided.
Charts were retrospectively reviewed for clinical , pathologic , and radiographic findings.
ChAT enzyme activity levels decreased significantly in the hippocampus of middle-aged 3xTg-AD mice compared to age-matched non-transgenic ( or wild type ) mice.
CH can be related to defects in either formation and migration of the thyroid gland ( dysgenesis ) or thyroid hormone synthesis.
CHC users reported modest satisfaction across various aspects of the CHC.
CHD4 knockdown activates silenced TSGs , revealing their role for blunting colorectal cancer cell proliferation , invasion , and metastases.
CHD4 recruits repressive chromatin proteins to sites of DNA damage repair , including DNA methyltransferases where it imposes de novo DNA methylation.
CHD and its risk factors ( lifestyle-related risk factors , diabetes , hypertension and cholesterol ) were assessed at baseline.
CHD or mortality hazards ratios were estimated using race-stratified and risk factor-adjusted Cox proportional hazards models.
CHD risk factors , i.e. obesity , hypertension , hyperlipidemia and diabetes , have been evaluated by routine methods.
CHEC-9 treatment of an in vitro model of α-synuclein aggregation also results in HSP70-dependent dissolution of these aggregates.
Checking PRL might be useful to stratify men for cardiovascular risk and to encourage appropriate lifestyle changes.
Checking that are a positive correlation between the degree of dependence and the index of QoL , especially in the physical component.
Cheek and lip compression strength demonstrated no age-related differences.
Chelate-free robust dual-modal imaging nanoprobes with high efficiency and low toxicity are of essential importance for tumor targeted dual-modal in vivo imaging.
Chem.
Chem.
Chem.
Chemical and enzymatic barriers in the gastrointestinal ( GI ) tract hamper the oral delivery of many labile drugs.
Chemical modification of LDL carboxyl groups , which could bind iron especially at pH @number@ decreases significantly iron binding to LDL and iron-induced LDL oxidation.
Chemical peel is a four step procedure : pre-peel preparation , peeling itself , recovery phase and maintenance phase.
Chemical peels are an alternative and / or a complementary treatment to the surgical procedures for skin aging.
Chemical peels are commonly combined with other nonsurgical cosmetic procedures to optimize results.
Chemical permeabilization employs saponin to selectively perforate the cell membrane while maintaining cellular architecture.
Chemistry has made vast and almost unparalleled contributions to telomere biology.
Chemogenetic activation of astrocytic Gs-coupled signaling reduced long-term memory in mice without affecting learning.
Chemokine CCL5 ( previously called RANTES ) has been shown to facilitate tumor progression and metastasis.
Chemokine mRNA and protein expression were analyzed by gene array and ELISA , respectively.
Chemokines are thought to play a crucial role in the early phase of the cutaneous radiation reaction.
Chemokines play a pivotal role in regulating the immune response through a tightly controlled expression.
Chemokines were the most differentially secreted proteins.
Chemoprevention with dietary compounds and their synthetic analogs has emerged as an attractive strategy to prevent carcinogenic progression to invasive cancer.
Chemotaxis of LAN-5 cells was assessed using transwell migration chambers and scratch wound migration assay.
Chemotherapy alone with temozolomide can be proposed to patients with methylated MGMT promoter.
Chemotherapy and artificial nutrition during the final weeks of life were considered as primary outcomes.
Chemotherapy and endocrine therapy can induce hypogonadism , leading to an increased rate of bone loss.
Chemotherapy has considerable effects on QOL in breast cancer patients.
Chemotherapy in elderly should be also evaluated by the patient's activities of daily living and the regimen of chemotherapy should be selected.
Chest CT scan showed left pleural effusion and pleural thickening.
Chestnoside B ( @number@ ) exhibited the strongest cytotoxicity with an IC Cocaine , a powerful vasoconstrictor , induces immune responses including cytokine elevations.
Chest radiography and serum angiotensin-converting enzyme findings were normal.
Chest wall kinematics ( via optoelectronic plethysmography ) and inspiratory muscle activity ( via surface electromyography ) were assessed simultaneously.
Chest X-ray ( CXR ) was always performed @number@ min after the end of the procedure.
Chewing ability was based on a five-item chewing index.
Chewing , however , rescues stress-induced suppression of long-term potentiation in the hippocampus and the stress-induced impairment of hippocampal-dependent learning.
Chez les cas dont la présentation est classique , la maladie débute au cours de la première année de vie.
CHF severity , emotional status , comorbidity , disability and disease-specific quality of life were also determined at the time of enrollment.
Chiang's method was used and the disability prevalence-adjusted life table was modified using Sullivan's method.
Chia oil activated the Nrf2 to arrest the pro-oxidative response to cholesterol and aging.
Chia oil has the ability to prevent oxidative damage and modify the inflammatory response , suggesting adequate regulation of the antioxidant system.
Chia oil has the highest recognized α-linolenic acid ( ALA ) content.
CHIA reduced the hypercholesterolemic effect by lowering levels similar to C ; also , ameliorated redox index.
Chicago , IL ) version @number@ was used.
Child behavior problems consistently predicted more conflict , whereas social skills predicted more closeness.
Child birth and child rearing necessitate high levels of energetic and nutritional investment : women who have children live shorter lives.
Childhood ability was measured at age @number@ using the Moray House Test.
Childhood abuse was assessed by four-item ( HITS ) scale.
Childhood acute lymphoblastic leukemia ( ALL ) ( age 0-14 years ) is @percent@ more common in Latino Americans than non-Latino whites.
Childhood adversities cast a very long shadow.
Childhood adversity is associated with telomere shortening , and several investigations have shown short telomeres in psychiatric disorders.
Childhood amnesia refers to the inability of adults to recall events that occurred during their infancy and early childhood.
Childhood and adolescent mental health have a lasting impact on adult life chances , with strong implications for subsequent health , including cognitive aging.
Childhood and adulthood SEP were positively related to standing balance and chair rise performance , but not to grip strength after basic adjustments.
Childhood chronic or serious illness was the most significantly associated single event affecting telomere length at the adult age ( P = @number@ ) .
Childhood cognition and education were not directly associated with evening cortisol.
Childhood cognitive ability was measured at ages @number@ @number@ and @number@ and educational level was reported at age @number@
Childhood diet is important for brain development.
Childhood growth has been linked with bone properties in adulthood , whereas less is known about the contribution of early growth to bone fracture risk.
Childhood IQ and adult morbidity and mortality are known to be linked even beyond socioeconomic variables.
Childhood IQ predicted statin use in old age.
Childhood is associated with improvements in task accuracy , response time , and reductions in intraindividual trial-to-trial variability in reaction times.
Childhood misfortune was measured at Time @number@ using indicators of financial strain , family structure , and abuse.
Childhood offers an important window to lay a base for future healthy ageing.
Childhood SEP inequalities in DBP were stable with age in both men and women.
Child mortality data were collected in @number@ and @number@
Child personality differentially related to midlife social relationships , well-being , and hardships.
Children < 16 years of age undergoing cardiac angiography formed the population for this prospective cohort study.
Children , adolescents and the elderly are at especially high risk of adverse reactions with antipsychotics.
Children aged 3-10 years received liposomal cytarabine @number@ mg with concomitant dexamethasone , and those aged > 10 years received @number@ mg.
Children aged @number@ @number@ and @number@ remembered @percent@ or more of the early-life events.
Children also showed higher scapulohumeral rhythm during lowering of the arm compared to adults from 90° to 60°.
Children and adults with pulmonary arterial hypertension ( PAH ) have similarities and differences in their background characteristics , hemodynamics , and clinical manifestations.
Children and elderly patients often need help in applying topical agents.
Children and older adults performed both conditions with similar reaction times.
Children and their mothers discussed unique events when the children were @number@ years of age.
Children and young adults identified as having BPD should be periodically monitored to identify the need for possible intervention.
Children are considered to be at higher risk of developing radiation-induced tumors due to the young age of exposure and increased tissue radiosensitivity.
Children cohabitating with older parents before death provided the most caregiving , compared to other siblings.
Children completed pain and function questionnaires and underwent a standardized joint examination by a pediatric rheumatologist.
Children completed subtests of the Delis-Kaplan Executive Function System ( D-KEFS ) , and their primary caregivers completed the Vineland Adaptive Behavior Scales-II.
Children consumed on average @number@ calories , @number@ g saturated fat , @number@ mg sodium , @number@ g fiber , and @number@ g sugar.
Children detected targets that appeared rarely or frequently.
Children develop attitudes towards aging from birth and are influenced by everyday factors.
Children diagnosed with cerebral palsy did not show proper qualitative features of @number@ months when analyzed at @number@ @number@ and @number@ months.
Children employ many resources to cope with the problems of parents who suffer from disabilities , cognitive impairment , and functional limitations.
Children exposed to ionizing radiation have a substantially greater breast cancer risk than adults ; the mechanism for this strong age dependence is not known.
Children finalized the decision by helping their parents to manage the uncertainties pertaining to institutionalization.
Children from both groups were arranged in three subgroups , according to the receptive vocabulary.
Children had to decide whether a phonological sequence consisted of a word or a non-word.
Children liked the salty taste of the blocker NaG more than did adults , but both groups liked the savory taste of MSG equally.
Children made less saccade errors compared to young adults , but they also exhibited longer response times in cued versus non-cued conditions.
Children mostly preferred water.
Children @number@ to @number@ years of age who attended pre-school were observed for a @number@ month period.
Children @number@ years old can perform a simultaneous motor and cognitive task but their performance strategies do not yet match young adults.
Children of 5-7 years of age performed the task at chance , indicating a delayed ability to understand the goal of the action.
Children of 5-9 years old and adults over @number@ with lower educational level and lower monthly income are the target persons to be intervened.
Children ordered and consumed significantly fewer calories and less sodium and sugar with meals ordered exclusively from the children's menu compared with the standard menu.
Children outperformed older adults when encoding times were short , and distracter effects were larger in children and older adults than in younger adults.
Children presented similar results regarding expression of NKp30 and KIR , but not NKp46.
Children receiving heart transplants at an older age may require additional emotional and educational support.
Children reported higher levels of parental stubbornness than parents self-reported.
Children's / adolescents ' reports should not be ignored nor replaced by proxy reports ; both reports should be analyzed together.
Children's behaviours were observed during free plays , and both children and caregivers ' locations were recorded.
Children's endorsement of memory functions , particularly social functions , was associated with more detailed and personally meaningful memories.
Children's hand was warmed to its baseline temperature between CPTs.
Children showed greater functional connectivity between VFC and nodes of the salience network.
Children showed larger right posterior negativities in the time window suggesting that they rely more on quantitative manipulation for solving these problems.
Children's perceptions of occurrence were related to parent disability and relationship characteristics , while parents ' self-reports were associated with their own personalities.
Children's response style to @number@ lateralized action prompts was recorded as either \ "mirror \ " or \ "transposed. \ "
Children's skill on this task has been shown to correlate with and predict future mathematical competence.
Children's speech was acoustically analyzed to evaluate how style-dependent differences were produced.
Children's tool innovation lags substantially behind their ability to learn how to make tools by observing others.
Children's verbal working memory capacity was assessed with the Automated Working Memory Assessment.
Children under @number@ years of age were randomly selected using a two-stage cluster sampling.
Children were divided into two groups : ≤3 months and ≥3 months to @number@ year.
Children were interviewed for personal memories concurrently with the memory function knowledge assessment and again @number@ months later.
Children were more likely than adults to be stereonegative on the FD2 , although none of the children were stereonegative on the Frisby.
Children were randomly assigned to one of two apparatus ( ice- vs. electric-cooled ) for all CPTs.
Children were segregated into those undergoing catheter placements with omentectomy or without.
Children were trained on the two tasks and retested following approximately equal retention intervals of both wake and sleep.
Children who are exposed to maternal diabetes in utero may be ' programmed ' for later development of obesity at a critical period of development.
Children who present with a palpable mass or symptoms of precocious puberty have a high likelihood of malignancy.
Children with ADHD performed worse on the working memory score compared with the controls.
Children with ASD often suffer from epilepsy and paroxysmal EEG abnormality.
Children with asthma or BHR should not SCUBA dive.
Children with blood glucose ≥ @number@ mg / dL during admission were regarded as cases.
Children with BMI either in overweight or obese category were excluded to generate reference intervals.
Children with BPD should be assessed to identify cognitive impairments and allow early intervention aimed at ameliorating their effects.
Children with delayed motor development revealed minor qualitative performance impairments as early as @number@ months but improved with age.
Children with developmental disabilities napped more like children in the typically developing group , who were , on average , @number@ months younger.
Children with greater exposure to institutional care had significantly shorter relative telomere length in middle childhood.
Children with kwashiorkor have nutritional edema and metabolic disturbances , including hypoalbuminemia and hepatic steatosis , whereas marasmus is characterized by severe wasting.
Children with MAS or RAS were @number@.5±3.0 years old at enrollment , and @percent@ were men.
Children with OI presented lower mean MCW values than did children with normal BMD at the beginning of treatment ( P < @number@ ) .
Children with progeria syndrome usually appear normal at birth and in early infancy.
Children with SAM showed metabolic profiles that were profoundly different from stunted and nonstunted controls , even after clinical stabilization.
Child skin is more sensitive than adult skin because natural defense mechanisms are not fully developed.
Chimeric mice lack typical compensatory utrophin upregulation , and show pathological remodeling of Connexin-43.
Chimpanzees are the closest phylogenetic relatives to humans , sharing more than @percent@ genetic sequence identity.
China and India currently hold the world's two largest DM populations.
China , Ghana and India had a higher prevalence of respondents with multiple risk factors than Mexico , the Russia Federation and South Africa.
China has formed a comprehensive network on cancer prevention and control.
China is encountering formidable healthcare challenges brought about by the problem of aging.
China must act quickly to curb continued increases in overweight and the associated economic costs , with particular focus on target groups.
China should develop appropriate medical relief policies for the elderly to help them gain access to necessary healthcare services.
China's small-scale pig keepers are the largest community of pork producers worldwide.
China's tradition of taking care of one's aging parents continues to evolve , as evidenced by the growth in nursing home residents in Shanghai.
China will need to come to terms with how to provide for the instrumental support needs of an aging society.
Chinese older adults have limited knowledge of help-seeking resources other than seeking assistance from local community service centers.
Chinese older adults valued their independence , and cultural intergenerational relations had an impact on taking action to prevent falls.
Chinese older adults were more likely to visit community centers than any other social or cultural venues.
Chinese participants were more likely to feel that drinking alcohol ( @percent@ ) had great impact ( average @percent@ ) .
Chinese patients with AD showed higher mean AD-CSF-Indices than nondemented controls ( AD = @number@.25-1.3 , normal = @number@.62-0.63 ; P < @number@ ) .
Chinese prescription Kangen-karyu , comprised of six crude drugs , has received much attention due to its numerous biological activities.
Chinese urban dwellers showed better health and survival than rural dwelling older adults.
Chinese version of CD-RISC was used to assess the resilience of the study participants.
Chin et al.
Chin implants are necessary in some patients to give good neck improvement.
ChIP assays revealed that WASP associated with DNA , although the affinity was relatively weaker than RNAP II.
Chip-based analysis revealed @number@ up-regulated and @number@ down-regulated circRNAs in AA samples ( fold change > @number@ ) .
CHIP noncanonically ubiquitinates SirT6 at K170 , which stabilizes SirT6 and prevents SirT6 canonical ubiquitination by other ubiquitin ligases.
ChIP studies revealed association of RARα and RXRα with the StAR proximal promoter.
Chi-square analyses for trend in rehabilitation content across age bands and additional analyses were performed.
Chi-square analysis and analysis of variance were used to screen for initial differences between groups.
Chi-square analysis of variance was used to determine any relationship effects.
Chi-square and Logistic regression were performed to analyze the clinical data.
Chi- square and t-tests examined the rural and urban differences.
Chi-squared and logistic regression tests were applied for data analysis.
Chi-squared tests were used to identify candidate variables for the first logistic regression model.
Chi square , Fisher's exact and two-tailed Student's t test were used to compare baseline characteristics and outcomes.
Chi-square statistics were used to verify differences among groups.
Chi-square testing revealed no association between ratings by nurses and residents.
Chi-square tests , analyses of covariance and multiple logistic regressions were performed as the main statistical methods.
Chi-square tests , ANOVAs , and Cox proportional hazard models were applied to examine the relationships between the predictors and medical outcomes.
Chi-square tests were performed to assess any relationship between gender and DMFT variables.
Chi-square test was used for categorical variables and independent samples RESULTS : DM group patients had a higher prevalence of comorbidities.
Chi-square test was used to perform the Hardy-Weinberg equilibrium test.
CHIV infection is known to cause debilitating rheumatologic disease.
Chlorella has been shown to inhibit UVB-induced MMP-1 level , however its regulatory molecular mechanisms have not been studied.
Chlorogenic acid is compatible to the active site of the adenosine A2A receptor as revealed through molecular modeling.
Chocolate consumption was obtained from a baseline food-frequency questionnaire.
Choice of disease definition may play the larger role in explaining differences in observed prevalence between these studies.
Choice of fall-prevention intervention may depend on patient and caregiver values and preferences.
Choice of solution : Geriatric order sets incorporating @number@ Beers guidelines and including geriatric prescribing advice and prepopulated order options were developed.
Choice parameters depend on the type of machine , location and type of lesion , and skin color.
' Choice ' was framed narrowly with respect to allowing palliative clients and families to determine visit time and frequency.
Cholecystectomy was performed in @number@ %.
Cholesterol concentrations of major lipoproteins and their subclasses were determined by HPLC with gel permeation columns.
Cholesterol is implicated in the development of late-onset Alzheimer's disease ( AD ) .
Cholesterol levels in general rise with age and high cholesterol has been associated with extreme longevity.
Cholesterol levels may influence white matter integrity , and cholesterol-related genes may exert age-dependent effects on the brain.
Cholesterol measures were not related to Aβ deposition in this cohort of nondemented elderly adults.
Cholinergic dysfunction is an early hallmark even before onset of dementia at the clinical stage of MCI.
Cholinergic neurons densely innervate the hippocampus , mediating the formation of episodic as well as semantic memory.
Cholinesterase , cholinesterase-dibucaine number , and immunoglobulin E required only @number@ age partitions and α-1-antitrypsin required only one.
Cholinesterase inhibitors and a partial NMDA receptor antagonist ( memantine ) have been identified as potential treatment options for AD.
Cholinesterase inhibitors can ameliorate psychosis symptoms.
Cholinesterase inhibitors have reproducible beneficial effects on cognitive and functional outcomes in patients with MD.
Chondrocyte aging is associated with cartilage degeneration and senescence impairs the regenerative potential of mesenchymal stem cells ( MSCs ) .
Chondrocyte dedifferentiation interfered with TGFβ signaling by decreasing TβRII mRNA and protein levels and subsequent TGFβ response.
Chondrocyte proliferation , differentiation , and apoptosis are important steps for endochondral ossification.
Chondrocytes below the fibrillated surface had dilated and irregular endoplasmic reticulum.
Chondrocytes differ from other somatic cells as articular cartilage is an avascular tissue.
Chondrocytes were prepared from cartilage specimens taken from patients with osteoarthritis who had received total hip or total knee replacement.
Chondrocyte , the only type of the cell that resides in the articular cartilage.
Chondroitin sulfate proteoglycans ( CSPGs ) are the main active component of perineuronal nets ( PNNs ) .
Chondrosarcoma is a primary malignant bone cancer , with a potent capacity to invade locally and cause distant metastasis.
Choosing an animal model is dictated by costs and animal lifespan that preclude large animal use.
Choosing the correct daily care regimen for your patients ' specific skin condition does not have to become an overwhelming task.
Choroidal neovascularization ( CNV ) characterizes the progression of exudative age-related macular degeneration ( AMD ) with the deterioration in the central vision.
Choroidal thickness changes from baseline ranged between - @number@ µm and + @number@ µm.
Chow-fed L-PHLPP2 mice had normal glucose tolerance but hepatic steatosis.
CHP showed an EVA reduction after a 5-year follow-up period.
CHPs should continuously transform their roles and functions to establish a lifelong health management system.
Chroma effects , however , were found exclusively in children and adolescents.
Chromatic aberrations ( longitudinal and transverse ) , astigmatism , coma , trefoil , and spherical aberration show good agreement with experimental averages.
Chromatin immunoprecipitation analysis revealed diminished GATA3 binding to the minor ( cancer-protective ) allele of rs17432750 , indicating a mechanism for its action.
Chromatin immunoprecipitation as well as gel-shift assays showed that parkin bound to the p53 promoter , and this binding was inhibited by S-nitrosylation of parkin.
Chromatin immunoprecipitations confirmed some of these genes as KDM5B targets , as they displayed reduced H3K4me3 levels in cells ectopically expressing KDM5B.
Chromatin is a complex and dynamic structure that needs to be maintained in a functional state throughout our lifetime.
Chromatin is highly dynamic and subject to extensive remodeling under many physiologic conditions.
Chromatin is inherently dynamic and likely needs to be actively maintained to achieve a stable cell phenotype.
Chromatin occupancy of GR was not predictive of Dex-regulated gene expression , contradicting the \ "trans-repression by tethering \ " model.
Chromatin remodeling is required for transcriptional activation and repression.
Chromatographic procedures disclosed a homogeneous fraction able to increase erythrocyte phosphatidylserine exposure.
Chromogranin A ( CgA ) is a highly efficient biomarker for diagnosis and follow-up of various endocrine tumours.
Chromosomal alterations are a feature of both aging and Alzheimer's disease ( AD ) .
Chromosomal and genomic instability due to telomere dysfunction is known to play an important role in carcinogenesis.
Chromosomal instability ( CIN ) , the persistent inability of a cell to faithfully segregate its genome , is a feature of many cancer cells.
Chromosomal telomere length shortens with repeated cell divisions.
Chromosomal translocations involving BCL2 , MYC , and IGH genes were not observed.
Chromosome 22q11.2 deletion syndrome ( 22q11.2DS ) is a neurodevelopmental disorder that is associated with a vast cognitive and clinical phenotype.
Chromosome abnormalities in humans are strikingly associated with increasing maternal age.
Chromosome and chromatid breaks , chromosome fusions , aneuploidy and polyploidy were increased in older Mdm2 transgenic mice compared with wild-type littermates.
Chromosome aneuploidy increase is a physiological phenomenon related to aging , but the role of low-level sex chromosome mosaicism in ovarian function is still undiscovered.
Chromosome congression is the alignment of chromosomes at the spindle equator , and is a prerequisite for faithful chromosome segregation.
Chromosome instability ( CIN ) is a common property of cancer cells and may be a contributing factor to cellular transformation.
Chromosome loss was the more frequent aneuploidy , mainly monosomy @number@
Chromosome translocations are especially frequent in human lymphomas and leukemias but are insufficient to drive carcinogenesis.
Chromothripsis might arise more frequently than previously thought in both gametogenesis and early human embryogenesis.
Chronic actinic damage affects all layers of the skin.
Chronic actinic damage of the skin manifests itself as extrinsic skin aging ( photoaging ) and photocarcinogenesis.
Chronic activation of monocytes and altered liver protein synthesis subsequently contribute to a hypercoagulable state.
Chronically elevated intraocular pressure leads to remodelling of the lamina cribrosa and narrowing of its pores through which ganglion cell axons leave the eye.
Chronic and degenerative diseases are the main causes of death in the aging population worldwide.
Chronic ankle instability ( CAI ) is a common condition following ankle injury that is associated with compromised balance.
Chronic back pain was the most common painful condition.
Chronic care professional modules were used to increase nurses ' knowledge and were measured by successful completion of a certification exam.
Chronic changes in resistance and heart rate were the dominant contributors to change in Ea.
Chronic cocaine use is associated with functional brain impairments potentially mediated by vascular pathology.
Chronic complications of sickle cell disease take an increasing role in the management of patients due to their morbidity and mortality impact.
Chronic Condition Indicator and Clinical Classifications Software were used to determine and classify codes from the International Classification of Diseases , Ninth Revision.
Chronic conditions , especially pain , will rise in prevalence as the population ages.
Chronic conditions of stress and affective dysregulation are associated with neuroimmunological insufficiency and inflammation , contributing to health risk and mortality.
Chronic conditions were associated with adverse health status outcomes across organ systems.
Chronic conditions were graded with the Common Terminology Criteria for Adverse Events ( version @number@ ) .
Chronic cytomegalovirus ( CMV ) infection may contribute significantly to T-cell immunosenescence , chronic inflammation , and adverse health outcomes in older adults.
Chronic disease affects patients both in psychological and physiological functions which limit their daily activity.
Chronic disease already accounts for @percent@ of U.S. health-care costs , foreshadowing an unsustainable financial burden for the aging population [ @number@ ] .
Chronic disease and disability prevalence increase steeply with frailty.
Chronic disease management initiatives have thus far focused on single disease entities.
Chronic diseases affect more than @percent@ of our aging population , but the majority of public and professional stakeholders retain a sense of care quality.
Chronic diseases are a growing concern around the globe.
Chronic diseases , functional , cognitive and affective status were considered as potential confounders when examining the risk for malnutrition by logistic regression models.
Chronic diseases have a tendency to occur simultaneously and where there are two or more such conditions , this is termed as ' multimorbidity'.
Chronic disruption of circadian clock function is implicated in increasing the risk of metabolic syndrome , cardiovascular events and development of cancers.
Chronic energy stress affects the longevity and the functional differentiation of older T cells.
Chronic exercise has been shown to prevent or slow age-related decline in cognitive functions in otherwise healthy , asymptomatic individuals.
Chronic exposure to CSE decreased the production of GDF11.
Chronic exposure to elevated levels of glucocorticoids has been linked to age-related cognitive decline and may play a role in Alzheimer's disease.
Chronic exposure to elevated stress hormones has been linked to a reduced response to chemotherapy through induction of DNA damage.
Chronic exposure to hyperglycemia was observed in @number@ % of the residents ( severe in @number@ % and moderate in @number@ % ) .
Chronic exposure to the psychobiological sequelae of childhood trauma could increase risk for PTSD and short LTL.
Chronic exposure to ultraviolet ( UV ) irradiation causes sunburn , inflammatory responses , skin cancer , and photoaging.
Chronic granulomatous disease ( CGD ) and inflammatory bowel disease ( IBD ) have overlapping gastrointestinal manifestations.
Chronic HCV infection results in functional exhaustion of CD4 + and CD8 + T cells likely contributing to viral persistence.
Chronic health conditions are commonplace in older populations.
Chronic heart failure ( HF ) is a frequent and important comorbidity which has a significant impact on prognosis in COPD , and vice versa.
Chronic heavy alcohol consumption is a risk factor for cortical bone fractures in males.
Chronic hepatitis B ( CHB ) treatment aims at long-term suppression of HBV replication and improvement in clinical outcomes.
Chronic hepatitis C virus infection ( C-HC ) is associated with higher mortality arising from hepatic and extrahepatic disease.
Chronic hyperglycemia causes increased level of reactive oxygen species which is thought to be involved in the pathogenesis of diabetes associated complications including cataract.
Chronic hyperinsulinemia may exacerbate inflammatory responses and increase markers of oxidative stress.
Chronic hypoxia causes vascular remodeling , which is central to the pathogenesis of hypoxia-induced pulmonary hypertension ( HPH ) .
Chronic ICD-10 codes were subsequently grouped into broader categories according to clinical criteria.
Chronic immune activation persists despite antiretroviral therapy ( ART ) in HIV + individuals and underpins an increased risk of age-related co-morbidities.
Chronic impairments of the brain resulted from formaldehyde stress could be one of the mechanisms involved in the process of senile dementia during ageing.
Chronic inflammation and associated cyclooxygenase-2 ( COX-2 ) expression in the colon epithelium are causally related to epithelial carcinogenesis , proliferation , and tumor growth.
Chronic inflammation and increased oxidative stress are underlying the uremia-associated immune deficiency.
Chronic inflammation and oxidative stress are hallmarks of aging.
Chronic inflammation in aging is characterized by increased inflammatory cytokines , bone loss , decreased adaptation , and defective tissue repair in response to injury.
Chronic inflammation in patients aging with HIV does not seem to be directly dependent on the CD4 : CD8 ratio.
Chronic inflammation is a hallmark of HIV infection.
Chronic inflammation is a prominent feature of aging and of common age-related diseases , including atherosclerosis , cancer and periodontitis.
Chronic inflammation is now recognized as a contributing factor to many age-associated diseases including metabolic disorders , arthritis , neurodegeneration , and cardiovascular disease.
Chronic inflammation is one of the common pathological bases underlying aging and aging-related diseases.
Chronic inflammation is recognized as a risk factor for the development of several malignancies.
Chronic inflammation represents one of the most consistent biologic features of aging.
Chronic inflammatory activity is commonly proposed as a promoter of biological aging in general , and of leukocyte telomere shortening in particular.
Chronic irritation of the conjunctiva and / or cornea is bothersome to the patients and may cause severe complications.
Chronic ischemia is therefore associated with fibrosis but also with nitric oxide-cGMP reduction.
Chronic itch in the elderly is a common problem , with a significant impact on quality of life and sleep in elderly patients.
Chronic itch may be attributable to several causes , including dry skin , immunosenescence and neural degeneration.
Chronic joint diseases have a major impact on society as patients suffer from pain and disability.
Chronic joint pain is a widespread problem that frequently occurs with aging and trauma.
Chronic kidney disease ( CKD ) , diabetes and cardiovascular disease constitute three interrelated conditions of strong public health relevance.
Chronic kidney disease ( CKD ) has a high prevalence in the elderly population.
' Chronic kidney disease ( CKD ) in older people ' is the focus of World Kidney Day @number@
Chronic kidney disease ( CKD ) is a common global health challenge especially with the currently aging world population.
Chronic kidney disease ( CKD ) is a widespread condition in the global population and is more common in the elderly.
Chronic kidney disease ( CKD ) is becoming a major public health problem worldwide.
Chronic kidney disease ( CKD ) is common and the estimated prevalence is about 9-13% in the general adult population.
Chronic kidney disease ( CKD ) is considered a model of accelerated aging.
Chronic lower respiratory tract disease is the third leading cause of death in people aged @number@ years and older.
Chronic , low grade inflammation is a characteristic of old age.
Chronic low-grade inflammation is a feature shared by osteoarthritis and metabolic disorders and may contribute to the genesis of both.
Chronic low grade inflammation is a fundamental mechanism of aging.
Chronic lung diseases are associated with substantial morbidity , frequently resulting in exercise limiting dyspnea , immobilization , and isolation.
Chronic lymphocytic leukemia ( CLL ) mainly affects older people : the median age at diagnosis is > @number@ years.
Chronic lymphocytic leukemia ( CLL ) remains an incurable disease.
Chronic lymphocytic leukemia is a disease of the elderly , and despite major advances in treatment , remains incurable.
Chronic lymphocytic leukemia was the major cause of death in patients with two or more comorbidities.
Chronic micro and macroscopic infarcts were noted.
Chronic microinflammation is a hallmark of many aging-related neurodegenerative diseases as well as metabolic syndrome-driven diseases.
Chronic mild metabolic acidosis is common among older adults , and limited evidence suggests that it may contribute to insulin resistance and type-2 diabetes.
Chronic noncommunicable diseases ( NCDs ) are now prevalent in many low- and middle-income countries and confer a heightened risk of disability.
Chronic non-terminal diseases , including postmenopausal osteoporosis , are associated with poor treatment compliance and persistence.
Chronic obese showed less widespread impairment than those who regained normal weight.
Chronic obstructive pulmonary disease ( COPD ) and ageing may contribute to malnutrition.
Chronic obstructive pulmonary disease ( COPD ) in old age is an increasing problem.
Chronic obstructive pulmonary disease ( COPD ) in older adults is a complex disorder with several unique age-related aspects.
Chronic obstructive pulmonary disease ( COPD ) is a chronic inflammatory disease of the lungs that usually manifests late in life.
Chronic obstructive pulmonary disease ( COPD ) is a leading cause of mortality worldwide.
Chronic obstructive pulmonary disease ( COPD ) is a major health problem , with increasing morbidity and mortality.
Chronic Obstructive Pulmonary disease ( COPD ) is an inflammatory syndrome that represents an increasing health problem , especially in the elderly population.
Chronic obstructive pulmonary disease ( COPD ) is associated with the accelerated aging of the lung.
Chronic obstructive pulmonary disease ( COPD ) is regarded as a disease of accelerated lung aging.
Chronic obstructive pulmonary disease ( COPD ) remains a major cause of morbidity and mortality worldwide.
Chronic obstructive pulmonary disease influenced functional capacity in CHF patients , as determined by the 6-minute walking test.
Chronic obstructive pulmonary disease is known to be associated with systemic inflammation.
Chronic obstructive pulmonary disease is one of the most common chronic diseases throughout the world affecting prevalently older people.
Chronic obstructive pulmonary disease was identified by the review of medical records.
Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease often originate early in life.
Chronic overnutrition and astrocytic IKKβ / NF-κB upregulation similarly impaired astrocytic plasticity , leading to sustained shortening of high-order processes.
Chronic oxidative stress is the major endogenous metabolic stress and contributes directly to telomere shortening and senescence.
Chronic pain after TKA in the elderly can be managed with both pharmacological and non-pharmacological techniques.
Chronic pain and itch are common hypersensitivity syndromes that are affected by endogenous mediators.
Chronic pain and pain over the last @number@ months were defined using the Total Pain Index ( TPI ) .
Chronic pain is a common , yet frequently overlooked and undertreated complaint among older patients.
Chronic pain is associated with large societal costs , but few studies have investigated the total costs of chronic pain with respect to elderly subjects.
Chronic pain is highly prevalent in the ageing population.
Chronic pain is increasingly recognized as a disease and accounts for substantial suffering and disability worldwide.
Chronic pain is more common in the elderly and impairs functioning and quality of life.
Chronic pain leads to progressive loss of independence and the need for long-term care , especially in the elderly.
Chronic pain status was independently associated with greater CAM use ( adjusted odds ratio , @number@ @percent@ confidence interval , @number@ @date@ ) .
Chronic pain was associated with impaired physical performance , and this relationship persisted after adjusting for likely confounding factors.
Chronic pain was present in @percent@ of patients with multimorbidity.
Chronic periodontitis is associated with systemic diseases such as atherosclerosis.
Chronic psychological stress may lead to biological aging and skin aging.
Chronic psychosocial stress is increasingly recognized as a risk factor for late-onset Alzheimer's disease ( LOAD ) and associated cognitive deficits.
Chronic pulmonary disease had a differential effect on function by HIV status ( Δβ ( coef ) @number@ p = @number@ ) .
Chronic respiratory diseases are a common complication of preterm birth , particularly among very immature infants or those suffering from bronchopulmonary dysplasia.
Chronic sickness has fallen across birth cohorts born between @number@ and @number@ particularly before birth year @number@
Chronic spontaneous urticaria ( CSU ) can also be associated with internal , infectious , autoimmune , or neoplastic diseases.
Chronic stress promotes the progression of apoptosis.
Chronic stress triggers several signaling cascades that can induce a condition called cellular senescence.
Chronic stress was evaluated with the Stress Symptoms List ( SSL ) , whereas coping strategies were assessed using the Jalowiec Coping Scale.
Chronic subdural haematoma ( cSDH ) , one of the most common neurosurgical entities , occurs typically in elderly patients.
Chronic sun exposure can result in numerous changes in human skin , particularly on the face , nape , and arms.
Chronic sympathetic activation induced by tobacco smoking also has some involvement in lipid metabolism and insulin resistance , both implicated in atheromatous disease.
Chronic treatment of young Tg2576 mice with UE2316 for up to @number@ months prevented cognitive decline but did not prevent Aβ plaque formation.
Chronic use of benzodiazepines should be avoided in order to extend disability-free survival.
Chronic white matter lesions ( WML ) have been proposed to be a predictor of poor outcome after acute stroke.
Chronic wounds are rarely seen in individuals who are otherwise healthy.
Chronobiology is a word derived from three Greek stems : kronos for time , bios for life and logos for study.
Chronodisruption is associated with alterations of the immune system , immunosenescence , impairment of energy metabolism , and reduction of pineal and extrapineal melatonin production.
Chronological age alone does not reflect heterogeneity in the aging process.
Chronological age alone should not be used as a criterion when evaluating a patient for free tissue transfer.
Chronological age as surrogate marker for intrinsic ageing has the most important influence on most facial skin ageing signs.
Chronological age is a fundamental and yet elusive variable in studies of many wild animals.
Chronological age is a well-established risk factor for the development of cardiovascular diseases.
Chronological age is not a good indicator of how each individual ages and thus how to maintain good health.
Chronological age is used as a marker for age-associated changes in cognitive function.
Chronological age probably represents an independent risk factor.
Chronological age represents the single greatest risk factor for human disease.
Chronological age was then subtracted from brain-predicted age to generate a brain-predicted age difference ( brain-PAD ) score.
Chronological aging independent of biological markers of aging is the primary risk factor for AF.
Chronological lifespan ( CLS ) is defined as the duration of quiescence in which normal cells retain the capacity to reenter the proliferative cycle.
CI adults who were more engaged in physical activities were more likely to improve in their cognitive status over time than their more sedentary peers.
CI adults with high ( but not low ) social engagement performed equivalently to CN adults on EF.
CI exerted positive short-term effects , but more information is needed on long-term consequences.
CIFLE for men was greatest in Cuba ( @number@ years ) and least in Brazil ( @number@ years ) .
Cigarette butts ( CBs ) , the most commonly discarded piece of waste , also represent a major health hazard to human and animal life.
Cigarette smoke contributes to premature aging and an increase in the incidence of psoriasis , acne and skin cancers.
Cigarette smoke extract ( CSE ) induced Nrf2 nuclear translocation in RPE cells with increased antioxidant and complement gene expression.
Cigarette smoke extracts ( CSE ) alter TLR4 expression and activation in bronchial epithelial cells.
Cigarette smoke is a complex and oxidative aerosol.
Cigarette smoke represents the major risk factor for chronic obstructive pulmonary disease ( COPD ) .
Cigarette smoking , aging , and male gender were the factors associated with the presence of paraseptal emphysema.
Cigarette-smoking and moderate alcohol drinking showed no clear impacts on new-onset diabetes in older Taiwanese.
Cigarette smoking causes various diseases , including lung cancer and cardiovascular disease , and reduces life span , though the mechanisms are not well understood.
Cigarette smoking has been associated with multiple negative effects on human skin.
Cigarette smoking has been proposed as a major risk factor for aging-related pathological changes and Alzheimer's disease ( AD ) .
Cigarette smoking is a leading modifiable cause of death worldwide.
Cigarette smoking is associated with cognitive decline and dementia , but the extent of the association between smoking and structural brain changes remains unclear.
Cigarette smoking is highly prevalent in patients with severe mental illness.
Cigarette smoking was reported in @percent@ of cases.
CI is strongly associated in both groups with BPH.
Cilia govern cellular functions ranging from motility to integration of mechanical and chemical signaling from the environment.
Cilia mutant cells undergo abnormal cell division with apparent defects in mitotic spindle formation , cellular spindle assembly checkpoint and centrosome amplification.
Ciliary ring diameter decreased ( @number@ ± @number@ mm ) with no decrease in circumlental space or forward ciliary body movement.
Cilostazol , a selective inhibitor of phosphodiesterase @number@ has been widely used in patients with atherosclerotic diseases and is known to increase HDL-cholesterol.
CIMT is also ( along with coronary calcium scoring ) recognized by the American Heart Association as a surrogate marker for coronary artery disease.
CIMT is independently associated with age.
CIND was defined as age-adjusted Mini-Mental State Examination score one standard deviation below the baseline mean score of participants without dementia.
Cinema as an art form has historically denied or ignored the fact that humans are sexual beings their whole lives.
Cine phase contrast magnetic resonance imaging was performed at @number@ aortic levels.
CIN in the elderly patients may be associated with prolonged renal dysfunction and poor prognosis.
( C ) In vivo cross-polarized image at @number@ nm.
Circadian aging in humans is characterized by a phase advance , accompanied by rhythm fragmentation and flattening.
Circadian disruption has been linked to carcinogenesis in animal models , but the evidence in humans is inconclusive.
Circadian rhythm disturbances are common in the elderly.
Circadian rhythm dysfunction and cognitive decline , specifically memory loss , frequently accompany natural aging.
Circadian rhythmicity differs with age among the Ache and may be a common aspect of reproductive senescence among men regardless of ecological context.
Circadian rhythmicity in wrist temperature motor activity and position were analyzed using different sensors.
Circadian rhythm is an internal biological clock that controls physiological processes.
Circadian rhythms and memory are intertwined , as circadian rhythms influence memory formation and recall in young and old rodents.
Circadian rhythms are associated with the preference for sleep-wake timing , also known as morningness-eveningness ( ME ) .
Circadian rhythms are autonomous anticipatory oscillators that control a large array of physiological and metabolic processes.
Circadian rhythms are generated by an intrinsic cellular mechanism that controls a large array of physiological and metabolic processes.
Circadian rhythms are regulated by a set of clock genes and mutations in clock genes result in short life in animal models.
Circadian rhythms optimize physiology and health by temporally coordinating cellular function , tissue function , and behavior.
Circadian rhythms orchestrate biochemical and physiological processes in living organisms to respond the day / night cycle.
Circadian rhythms permeate mammalian biology.
Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in the vast majority of species on Earth.
Circadian rhythms regulate a wide variety of physiological and metabolic processes.
Circadian rhythms were not associated with lipid peroxidation in healthy controls , where aging was the only significant predictor.
Circadian system maturation was associated with an increase in amplitude and a reduction in skin temperature during sleep.
( Circ J @number@ 74 : @number@ - @number@ ) .
CircRNAs are preferentially expressed in neural tissues and some are found at synapses , suggesting possible functions in the nervous system.
Circular RNAs ( circRNAs ) are a class of newly identified non-coding RNAs with regulatory potency by sequestering miRNAs like a sponge.
Circular RNAs ( circRNAs ) are a unique class of endogenous RNAs which could be used as potential diagnostic and prognostic biomarkers of many diseases.
Circulating 25 ( OH ) D was measured by protein-bound assay.
Circulating amylin oligomers that cross the blood-brain barrier and accumulate in the brain may be an important contributor to diabetic cerebral injury and neurodegeneration.
Circulating C1q was identified as a novel activator of Wnt / β-catenin signaling , promoting systemic aging-related phenotypes including sarcopenia and heart failure.
Circulating CD19 CONCLUSIONS : Peripheral B and T cells are altered in pediatric patients with early AD , but T cells predominate in skin lesions.
Circulating concentrations of epidermal growth factor increased significantly in the MCT group from @number@ ± @number@ to @number@ ± @number@ pg / ml.
Circulating concentrations of methionine were not associated with lung cancer risk overall or in important subgroups.
Circulating creatine phosphokinase , a clinical marker of muscle damage , was also significantly associated with FI34.
Circulating cytokines of relevance for cognition and aging were measured with ELISA.
Circulating GDF-11 levels did not decline with age or correlate with ageing in healthy Chinese males.
Circulating levels of IGF-I change in AD patients and are implicated in the clearance of brain amyloid beta ( Aβ ) complexes.
Circulating markers of antioxidant capacity and inflammation were not related to FMD.
Circulating microRNA ( c-miRNA ) have the potential to function as novel noninvasive markers of the underlying physiological state of skeletal muscle.
Circulating microRNAs ( miRNAs ) hold great promise as easily accessible biomarkers for diverse ( patho ) physiological processes , including aging.
Circulating microRNAs ( miRNAs ) may contribute to inter-individual changes in gait speed with AEX.
Circulating miRNAs may serve as a novel class of minimally invasive biomarkers for prognosis.
Circulating MP were isolated from venous citrated blood.
Circulating MRP- @date@ may be a target to test different antiplatelet strategies in ACS.
Circulating nonesterified or free fatty acids ( FFAs ) may contribute to the development of cardiovascular pathology and correlate with ischemia in acute cardiovascular conditions.
Circulating number of EPCs were analyzed by flow cytometry.
Circulating phylloquinone was measured by using reversed-phase high-performance liquid chromatography.
Circulating posttransplant anti-human leukocyte antigen class I and class II antibodies correlated with increased endothelial cell area ( P < @number@ ) .
Circulating progenitor cells were enumerated by flow cytometry.
Circulating soluble-Klotho ( sKlotho ) is produced in the kidney and is a putative anti-aging and vasculoprotective hormone.
Circulating Treg cells are increased in several cancers.
Circulating tumor cells ( CTCs ) are in limited numbers and heterogeneous , making their detection , isolation , and enumeration a major challenge.
Circulating tumor DNA ( ctDNA ) containing mutations can be identified in the plasma of cancer patients during the course of the disease.
Circulating vasoactive factors may provide targets for diagnostic tools of calcified aortic valve disease.
Circulatory AKI was the most important cause in both groups ; however , septic or toxic AKI contributed relevantly in younger patients.
Circulatory levels of insulin-like growth factor ( IGF-1 ) , glucose , and cortisol have been previously associated with facial aging.
Circumstantial evidence suggests that subtle reductions in fetal androgen production may be the cause of adult male reproductive disorders due to reduced testosterone production.
CIRENS chronotype scores declined with age and were not affected by sex.
Cirrhosis-associated telomerase mutations led to reduced telomerase activity and defects in maintaining telomere length and the replicative potential of primary cells in culture.
Cirrhosis patients with TERT mutations showed shortened telomeres in white blood cells compared to control patients.
Cirrhosis was defined as a cut-off of @number@ kPa.
Cisd2 also ameliorates age-associated degeneration of the skin , skeletal muscles and neurons.
CISD2 , an evolutionarily conserved novel gene , plays a crucial role in lifespan control and human disease.
Cis- or trans-18 : 1n9 triglycerides ( @number@ μM ) caused no apparent changes in the numbers of viable progeny of wild-type N2 animals.
Cisplatin is the most potent and widespread used chemotherapy drug for lung cancer treatment.
Cisplatin was previously found to induce the ATM-dependent phosphorylation of ΔNp63α in squamous cell carcinoma ( SCC ) cells.
Cistotonometry presented detrusor overactivity in two patients , treated with M cholinergics.
CIs were identified through an online inventory , recruited by e-mail and interviewed between March and @date@ .
Citation : Baccarelli AA , Hales N , Burnett RT , Jerrett M , Mix C , Dockery DW , Pope CA III.
CITATION FORMAT : · Do TD , Sutter R , Skornitzke S et al.
Citation information is as follows : NIH Medical Rehabilitation Coordinating Committee.
Citations from available articles were also reviewed for additional references.
Cited articles were peer reviewed and included prospective , retrospective and basic science studies , systematic reviews and Center for Disease Control and Prevention data.
Cite this article : The mechanisms of aging that are involved in the development of idiopathic pulmonary fibrosis ( IPF ) are still unclear.
Citrulline has anti-inflammatory properties and exerts beneficial effects on various impaired functions in aging.
Civet differed significantly from Freesurfer in large frontal , parietal , temporal and occipital regions ( p < 0.05 ) .
CI was found in > 70% of men in both the Asian and Caucasian groups ( p > 0.05 ) .
CKB and PRDX2 may serve as biomarkers or therapeutic targets for the developmental potential of oocytes.
CKD affects @percent@ of persons older than @number@ years of age and can double the risk for physical impairment , cognitive dysfunction , and frailty.
CKD appears to be a condition of soluble klotho deficiency.
CKD can be seen as a state of hyperphosphatemia-induced accelerated aging associated with Klotho deficiency.
CKD in the elderly rarely occurs in isolation from other chronic conditions and can often be a marker of these conditions themselves.
CKD is an important predictor of CVD in Japan , similar to other parts of the world.
CKD is a risk factor for cardiovascular disease ( CVD ) and cardiovascular disease can lead to CKD.
CKD is defined by the presence of kidney damage or decreased glomerular filtration rate.
CKD patients have significantly higher bone marrow fat than healthy adults.
CKD was among the fastest growing causes of death in the past @number@ years in age-adjusted terms.
CKD was defined as eGFR less than @number@ mL / min / 1.73 m ( @number@ ) .
CL4176 animals treated with silymarin showed delayed paralysis via enhancing resistance to oxidative stress.
Claiming @percent@ of all deaths , these diseases are currently the main murderer worldwide.
Claims-based data sets are useful for studying public health at a population level but lack physical measurements.
Claims data were used to identify Medicare Advantage patients aged ≥65 years newly initiated on antimuscarinic OAB treatment.
Claims of accelerated or premature aging are frequently made.
Clarification of the effects of pain on dual-tasking performance is also important , given the strong link between falls and dual-tasking.
Clarification of the molecular mechanisms that accompanies corpus cavernosum aging and aging-associated ED will aid new perspectives in the development of novel mechanism-based therapeutic approaches.
Clarification of these concepts is needed for educational and research purposes.
Clarification of these relationships in larger samples could aid in understanding differential mechanisms underlying stress-related cellular aging in healthy and depressed populations.
Clarification of this safety issue could allow treatment to be considered for a sizeable segment of the aging male population.
Clarified supernatants were used for the measurement of pro-inflammatory cytokines , IL-1β , IL-6 , and TNF-α.
Clarifying current and future population trends in dementia prevalence and risk has important implications for patients , families , and government programs.
Clarifying what factors affect foot morphology is helpful in understanding the basis of foot deformity and foot dysfunction.
Classical chemotherapy is inefficient in metastatic dedifferentiated liposarcoma and novel biological markers are needed for improving its treatment.
Classical in vivo assays for endocrine disruption are comprehensive but time-consuming and require sacrifice of experimental animals.
Classically , the isolation of bacteria-containing phagosomes has been performed by sucrose gradient centrifugation.
Classical theories argue that high levels of extrinsic mortality should select for the evolution of shorter lifespans and earlier peak fertility.
Classic case-control studies , genome-wide association studies , and high-throughput sequencing have permitted identification of a variety of genetic variants seemingly associated with longevity.
Classic psychometric parameters were also analyzed.
Classic surgical approach consisted of complete excision of branchial lesions , dissection of recurrent laryngeal nerve and partial thyroidectomy.
Classic textbook depictions of mitochondria portray these organelles to be static bean-shaped structures.
Classic treatment can delay progression of glaucomatous optic neuropathy by lowering intraocular pressure medically or surgically.
Classic twin studies have shown that genetic components may contribute up to @percent@ of the heritability of telomere length.
Classification accuracies using OARSI score-based group membership were generally higher when compared with grade-based group membership.
Classification accuracy associated with a score of four or less out of six was very high.
Classification accuracy was evaluated via leave-one-out cross-validation to ensure generalization of performance.
Classification level @number@ ( PCA ) defines the core clinical , cognitive , and neuroimaging features and exclusion criteria of the clinico-radiological syndrome.
Classification occurs by means of color distances between cells and a learned set.
CLASSIFICATION OF EVIDENCE : This study provides Class I evidence that high-dose creatine is safe and tolerable.
CLASSIFICATION OF EVIDENCE : This study provides Class III evidence that SOPT improves UFOV performance among persons in the mild to moderate stages of PD.
Classification of individuals based on patterns of brain activity observed in functional MRI contrasts may be helpful for diagnosis of neurological disorders.
Class @number@ had only @number@ @number@ or @number@ comorbid conditions , and both class @number@ and class @number@ had @number@ or more comorbid conditions.
Class @number@ ( @percent@ of the sample ) had the highest probabilities ( > 90% ) of congestive heart failure and myocardial infarction.
Class @number@ ( @percent@ of the sample ) had the highest probabilities of cancer , incontinence , and kidney disease.
Class @number@ ( @percent@ of the sample ) had the lowest probabilities for most conditions.
CLASS QS trends agreed with those from visual QS , with both showing stronger correlations than nonstate specific trends.
Class-specific penalization enhanced separation of latent classes with respect to covariates , but only in scenarios where there was a true separation.
Claudin @date@ be a novel molecular target for prostate cancer therapy.
Claudin @number@ was overexpressed in prostate cancer clinical samples compared to benign tissues.
Clavicular region irradiation was not performed.
CLA was significantly moved along the muscle during the stair ascent and descent in both young and elderly ( p < 0.05 ) .
Cldn10-positive cells in IPF lungs displayed marked pleomorphism and were found in varied arrangements , suggesting their phenoconversion.
Clear age and gender differences related both to the content of atherogenic fractions of lipids in the blood , and types of dyslipidemia were revealed.
Clearance during sleep is as much as two-fold faster than during waking hours.
Clearance , expressed as per kilogram , is increased in children compared to adults.
Clearance of particles from the lung through the mucociliary elevator is decreased and associated with ciliary dysfunction.
Clearance of senescent cells that accumulate with age improves health span , implicating cellular senescence as a contributing factor to the aging process.
Clearance of the virus should be intensively attempted in these patients.
Clearance was found to change in a nonlinear manner with bodyweight.
Clear changes were evident between level and incline surfaces regardless of fall risk as defined by @number@ different objective balance measures [ corrected ] .
Clear differences between men and women appear in the field of functional components , which are significantly more important for women than for men.
Clear differences in EQ-5D were found with respect to the severity of pain.
Clear evidence in support of this approach , however , is lacking.
Clear evidence is lacking , however , regarding whether inflammation relates to cognition in midlife via changes in brain morphology.
Clear evidence supporting any therapeutic intervention except renal replacement therapy remains elusive.
Clear images were chosen for analysis.
Clear inverse dose-response relationships with F2RL3 methylation intensity were seen for both current intensity and lifetime pack-years of smoking.
Clear lenses ( in humans 49-71 years of age ) were used as control.
Clearly amnestic patients with a positive amyloid scan have prodromal AD and a poor prognosis for dementia within @number@ years.
Clearly , antiresorptive treatment reflected favorable effects on the multifunctional osteocytic cells that are a prerequisite for bone's structural , metabolic and mechanosensory integrity.
Clearly , identifying the metabolic pathways and specific genetic factors is the next important stage in this research area.
Clearly innovative prevention and treatment strategies are needed.
Clearly , iPS cells present a number of exciting possibilities , including disease modeling and therapy.
Clearly , lipodystrophy , dysregulation of the gut-liver axis and HIV infection itself may each contribute simultaneously to NAFLD pathogenesis.
Clearly , more research into other aspects of nutrition and their role in prevention of muscle loss is required.
Clearly , more work is needed to better understand the controversial impact of fat and obesity on skeletal development and fracture risk during childhood.
Clearly , oral diseases are highly prevalent in the globe , posing a very serious public health challenge to policy makers.
Clearly the farthest advance has been achieved with treatments developed for diseases of the cornea and the retina.
Clearly , there is a need for new thinking around the scope of practice debate.
Clear understanding of the triggers and responses of the UES will enable clinicians to choose the correct therapy for their dysphagic patients.
Cleavage of amyloid precursor protein ( APP ) by β- and γ-secretase generates amyloid-β ( Aβ ) and APP intracellular domain ( AICD ) peptides.
Cleavage of decorin by neutrophil elastase significantly augmented fragmentation of type I collagen fibrils by MMP-1.
Cleavage of tau at Asp421 occurs early in Alzheimer disease , and Asp421-cleaved tau likely negatively impacts neuronal function.
Cleaved-caspase @number@ immunoreactivity was marginally elevated in DEVILated myofibers , but unaccompanied by nuclear DNA fragmentation.
Clefts with necrotic tissue were observed in cartilage along with progressive calcification.
CL has been shown to interact with a number of IMM proteins , including the respiratory chain complexes and substrate carriers.
Client-level data were employed to identify HC-QI covariates.
Client Satisfaction Questionnaire was used to assess patient satisfaction with treatment.
Clients embedded in family , diverse and religious networks had significantly more positive relationships than clients embedded in restricted networks.
Clients embedded in restricted networks had significantly higher social isolation scores and were lonelier than clients in diverse and family networks.
Clients in residential settings are increasingly likely to have complex problems.
Clients were also satisfied with the multi-component LWAH service.
Climacteric symptoms could be found in @percent@ ( 1287 / 1641 ) women during menopausal transition , which were mainly mild to moderate symptoms.
Climate change is an important issue for Australia.
Climate change research forecasts that Australia will experience accelerated warming due to anthrogenic activities.
Clin.
Clin.
Clincopathological analysis showed the decreased level of @number@ hmC in HCC was associated with tumor size , AFP level and poor overall survival.
Clinical abilities decline with age , making older anesthesiologists more likely than their younger colleagues to be associated with adverse patient events.
Clinical adjudication of cognitive status , prevalence of stroke and diabetes , systolic blood pressure , and gait speed were assessed at time of neuroimaging.
Clinical anatomy of trigeminal nerve root was investigated on @number@ cadaver human skull base specimen.
Clinical and academic researchers will benefit from using the presented model and software.
Clinical and basic studies suggest that testosterone plays an important role in ventricular repolarization.
Clinical and biochemical parameters of all subjects were determined.
Clinical and comorbid pathological features linked to HS-Aging pathology were analyzed using National Alzheimer's Coordinating Center ( NACC ) data.
Clinical and demographic characteristics were carefully recorded.
Clinical and epidemiological cohorts , intensively assessed , provide more sensitive detection of less severe cognitive impairment but are often costly.
Clinical and epidemiological studies have suggested the existence of intermediate factors that may be associated with additional risk of PD.
Clinical and histopathologic features were compatible with the entity of white fibrous papulosis of the neck ( WFPN ) .
Clinical and instrumental parameters were assessed at days @number@ @number@ @number@ and @number@
Clinical and laboratory data were also examined before and after @number@ months of follow-up and the results between the two groups were compared.
Clinical and laboratory data were examined using conventional methods.
Clinical and laboratory information was collected and CAC scores were measured using multi-detector computed tomography.
Clinical and laboratory parameters reflecting nutritional status and immune function were collected at baseline.
Clinical and laboratory parameters were collected from the medical files.
Clinical and neuropsychological data were prospectively collected from @number@ cases.
Clinical and neuroradiological deterioration occurred , and our patient died five months after the diagnosis due to respiratory failure.
Clinical and psychological evaluations were performed and the expression level of oral mucosal epithelial MUC1 was analyzed.
Clinical and research utility and validity of MCI are hotly debated.
Clinical and socio-demographic variables were collected from medical records.
Clinical applications of rapamycin for reversing pseudo-hypoxic state and lactate acidosis are discussed.
Clinical applications such as neurodegenerative diseases could be considered thanks to specific functional studies of CP.
Clinical assessment of androgen status relevant to clinical biochemists and chemical pathologists is outlined in this review.
Clinical assessment of older people at heightened risk of financial exploitation ( also termed social vulnerability ) is a difficult task.
Clinical assessments and Minor test were performed at baseline and Days @number@ @number@ @number@ and @number@
Clinical assessments for efficacy and tolerability were conducted at baseline , baseline post-application , week @number@ and week @number@
Clinical assessments were performed at screening / baseline and at week @number@
Clinical attention to PAD as a potential contributor to poor physical function is warranted in community-dwelling older adults.
Clinical balance and fear of falling were assessed with the mini-Balance Evaluation Systems Test ( mini-BESTest ) and Activities-specific Balance Confidence Scale , respectively.
Clinical balance and mobility tests may be able to detect such aging effects.
Clinical characteristics and echocardiographic parameters were analyzed and compared.
Clinical characteristics and in-hospital and long-term outcomes were compared between men and women.
Clinical characteristics and outcomes were compared between younger and older IMN patients.
Clinical characteristics , demographic data , comorbid conditions , and cardiovascular risk factors were obtained.
Clinical characteristics of MCI depend on the main etiological factor.
Clinical clues and imaging findings represent supportive features.
Clinical computed tomography images of the same specimen were used to create a corresponding finite element model.
Clinical correlates of microangiopathy appear as subcortical cognitive alterations , but data are controversial about dementia risk.
Clinical course did not differ significantly between the groups with different nutritional status.
Clinical cure rate is highly subjective in critically ill patients where symptoms may be related to other intercurrent events.
Clinical cutpoints of PNF tests were used to create a neuropathy score from @number@ to @number@ ( higher values , greater neuropathy ) .
Clinical data about possible beneficial effects on cholesterol or in the bone are largely missing.
Clinical data and blood samples were collected ( lipids , adrenal function , glucose ) .
Clinical data and lifestyle profiles were obtained through standardized questionnaires.
Clinical data are consistent when reinterpreted in the proper framework , whereas molecular evidence remains controversial.
Clinical data have demonstrated an independent association between arterial stiffness and cardiovascular outcomes.
Clinical data included 8-year overall survival , tumor staging , histological grading , regional localization , and molecular tumor characteristics.
Clinical data included age , gender , type @number@ diabetes mellitus , and hypertension.
Clinical data , neuropsychological measures , cerebrospinal fluid Aβ , total and phosphorylated tau and α-synuclein and MRI and FDG-PET scans.
Clinical data on potential interactions between vitamin D3 deficiency and AGE accumulation are sparse.
Clinical data showed persistent inflammation , immunosuppression , and protein depletion.
Clinical data since @number@ are included in this review.
Clinical data were collected and Charlson Comorbidity Index scores were calculated.
Clinical data were collected based on the Cumulative Illness Rating Scale ( n = @number@ ) .
Clinical data were obtained by retrospectively reviewing the medical record.
Clinical decision rules ( CDRs ) have been developed and implemented for VTE.
Clinical deficits of mobility , respiratory , renal , malignancy , thyroid , and impaired cognition also may be independently associated with mortality.
Clinical dementia diagnoses were made through medical and psychological examinations.
Clinical diagnoses of probable DLB ( n = @number@ ) were made according to published criteria.
Clinical diagnosis is based on recognition of common clinical features and definitive diagnosis is by identifying the mutation in the LMNA gene.
Clinical downtime was 3-5 days.
Clinical effectiveness of treatment was assessed by both study physicians and patients @number@ months after the final laser treatment using a quartile grading scale.
Clinical efficacy was assessed with a CCD color microscope , through the digitization of images before and after treatment.
Clinical efforts are currently underway to substantiate upper facial injections ( the corrugator muscles are the target muscles ) of BoNT-A as an antidepression therapy.
Clinical epidemiology data were also collected from stroke survivors on parameters such as stroke severity and risk factors.
Clinical estimation was done with the use of specially developed Clinical Psychopathological Chart.
Clinical evaluation and vascular tests were assessed at baseline and after intervention.
Clinical evaluation of the participants was conducted in @number@ National Institute on Aging's Alzheimer Disease Centers.
Clinical evaluations for efficacy and tolerability , as well as standardized digital photographs were conducted at baseline and at weeks @number@ @number@ and @number@
Clinical evaluations for efficacy were made by a board-certified dermatologist at baseline and after six and @number@ weeks of product use.
Clinical evaluation showed a significant reduction in pocket depth ( p < @number@ ) to their normal values ( ≤3 mm ) .
Clinical evaluation was less accurate than scientific methodology for static lines.
Clinical events and patient attitudes / experience were also evaluated.
Clinical evidence derived from each proposal formed the basis for an inferential conclusion based on the level of confidence provided by the trial data.
Clinical evidence indicates beneficial roles of neuraxial anesthesia / analgesia in the prevention of VTE for patients undergoing high risk surgical procedures.
Clinical evidence showed the beneficial effects of vitamin D treatment on muscle mass and function in older people.
Clinical evidence to support this is presented , including discussion of the successful psychoanalysis of a woman in her seventies.
Clinical examination and laboratory findings indicated a systemic process with cardiac involvement.
Clinical examinations identified an inflamed mucosal opening with pus over an area of necrotic bone.
Clinical examinations , physical tests and questionnaires will be administered to all participants at baseline , and after @number@ @number@ and @number@ years.
Clinical factors were assessed via a medical chart review.
Clinical features and examination findings were compared between groups.
Clinical features consistent with Alzheimer disease and mixed dementia were most common , each accounting for @percent@ of dementia cases.
Clinical feature selection problem is the task of selecting and identifying a subset of informative clinical features that are useful for promoting accurate clinical diagnosis.
Clinical features included the presenting symptoms , Albright hereditary osteodystrophy features , and resistance to hormones.
Clinical features of different PS variants , response to treatment and progression of disease in this age group remain to be determined.
Clinical features of the disease have suggested and corroborated pathological events.
Clinical features were retrospectively evaluated.
Clinical findings in animals that did not survive to the end of the study included thinness , lethargy , and abnormal breathing.
Clinical follow-up between @number@ and @number@ months tracked progression to dementia.
Clinical follow-up had been done for > 600 days , and a prognostic combined event was defined.
Clinical form of MS and sex do not predict the appearance of seizures.
Clinical fracture risk alone might be used if DXA facilities are unavailable.
Clinical Frailty Scale scores were not associated with disability in basic activities of daily living or with cognition.
Clinical functional characteristics but not demographic variables explained participation in resistance exercise.
Clinical , genetic , and pathological findings suggest a close relationship between amyotrophic lateral sclerosis ( ALS ) and frontotemporal dementia ( FTD ) .
Clinical genetic studies of childhood phenotypes have not been blurred by modern medicine either.
Clinical grading to assess the efficacy and tolerability was conducted on the face at baseline and at weeks @number@ @number@ and @number@
Clinical guidelines are needed to support physicians in their decision to continue or discontinue medications near the end of life.
Clinical guidelines can thus inadvertently jeopardize the safety of persons suffering from multiple diseases.
Clinical hallmarks of this condition are eruptive xanthomas , recurrent pancreatitis and abdominal pain.
Clinical history and medical treatment of diabetes , hypertension , and hyperlipidemia were assessed at both evaluations.
Clinical , imaging , and laboratory data were assessed to compute CPIS and severity scores.
Clinical implementation and prospective testing for validation as a screening tool would be necessary.
Clinical implementation of CPC-based therapy in elderly patients would benefit tremendously from understanding molecular characteristics of senescence to antagonize aging.
Clinical implications and methodological limitations are discussed.
Clinical implications are discussed.
Clinical implications are discussed with respect to practical applications in rehabilitation settings.
Clinical implications are that children under @number@ years are more variable than older children when walking either slower or faster than self-selected walking speed.
Clinical implications as well as limitations of the present study were discussed.
CLINICAL IMPLICATIONS : Findings show that older adults engage in sexual activity.
Clinical implications of the findings are also discussed.
CLINICAL IMPLICATIONS : The HIS-Q-SF could be a useful tool in clinical practice , epidemiologic studies , and other academic research settings.
CLINICAL IMPLICATIONS : TRT-related benefits in QOL and sexual function are well maintained for up to @number@ months after initiation of treatment.
Clinical improvement of periocular rhytides was achieved after a single sonic infusion treatment ( @number@ seconds / eye ) .
Clinical improvement of rhytids and pigmentations in facial and non-facial skin was proportional to increasing energy and density settings.
Clinical improvement , skin elasticity and subjective satisfaction were evaluated at every visit ( baseline , @number@ @number@ and @number@ weeks ) .
Clinical improvements were maintained at the 60-day follow-up , demonstrating the prolonged photothermally induced biological effect on skin function and texture.
Clinical improvement was evaluated by two blinded physicians who assessed comparative photographs using a four-point scale at baseline and @number@ months after the final treatments.
Clinical improvement was judged by a panel of observers according to the Hay scale.
Clinical information , functional capacity ( FC ) , hemoglobin , RDW , EF , and pro-B type natriuretic peptide ( proBNP ) were recorded.
Clinical information was retrospectively collected from medical charts.
Clinical interventions that are intensive , individualized , and delivered over time to parallel chronic disease trajectories seem most effective.
Clinical interventions that improve sleep and reduce concomitant inflammatory dysregulation hold promise for chronic pain management.
Clinical intervention trials have also demonstrated that supplementation with vitamin E is neutral or even harmful for preventing age-related diseases in humans.
Clinical investigators rated the improvement of mottled pigmentation considerably higher ( 51-75% ) .
Clinical isolates were screened centrally for azole resistance and , if applicable , underlying resistance mechanisms were analysed.
Clinically , actinic keratoses ( solar keratoses ) are keratotic lesions that occur on chronically sunlight-exposed skin.
Clinically , balance training for older adults may include the exploration and instruction of atypical movement patterns.
Clinically based studies using radioactive tracers with children have focused on resting state CBF.
Clinically diagnosed dementia was assessed by specialists using diagnostic criteria.
Clinically healthy older adults completed a pair of behavioral memory and perceptual inhibition tasks and then underwent structural brain imaging.
Clinically , iERM progresses through different stages characterized by an increased thickness and wrinkling of the membrane.
Clinically important short-term outcomes have improved for this population , but little is known about long-term outcomes.
Clinically , it is not easy to distinguish GSS from spinocerebellar ataxia ( SCA ) , especially in the early stage of disease.
Clinically , localised deep periodontal pockets and inflammation were noted on affected aspects in four cases.
Clinically manifest CVD was pre-defined and ascertained from interviews and hospitalisation records.
Clinically meaningful change was demonstrated on the CODE scale.
Clinically , patients initially present with short-term memory loss , subsequently followed by executive dysfunction , confusion , agitation , and behavioral disturbances.
Clinically relevant models of AML are required to advance drug development for an aging patient cohort.
Clinically relevant results are provided to all participants.
Clinically significant depression was defined using a cut-off score of @number@ or greater.
Clinically significant depressive symptoms were measured using the validated Chinese version of Geriatric Depression Scale.
Clinically significant findings will be expected that will help reduce suffering in the sense of \ "total pain \ " for people with dementia.
Clinically , there are many issues in CdLS faced by the individual , parents and caretakers , professionals , and schools.
Clinically , this damage can manifest as skin cancer and premature skin ageing as well as the development of pterygia and premature cortical cataracts.
Clinically , this finding has implications in esthetic and functional upper eyelid blepharoplasty.
Clinically , we found that SIRT6 was upregulated in human skin squamous cell carcinoma.
Clinical magnetic resonance imaging ( MRI ) ( n = @date@ ) was evaluated.
Clinical manifestations of major depressive disorder ( MDD ) have been linked to structural and functional alterations in fronto-limbic circuits and white matter microstructural abnormalities.
Clinical manifestations of such photoaged or photodamaged skin include wrinkles and irregular pigmentation.
Clinical manifestations of these biological processes are age-associated illnesses occurring in greater numbers ( multimorbidity ) , but they are not accelerated.
Clinical measurement of mobility and balance should be prioritized.
Clinical medicine faces many challenges , e.g. applying personalized medicine and genomics in daily practice ; utilizing highly specialized diagnostic technologies ; prescribing costly therapeutics.
Clinical mentors were recruited and trained to provide clinical and cultural support for participants.
Clinical , neuropsychological and morphometric features were similar in the stratified subgroups.
Clinical observations of individuals with greater neuropathology who function better than some individuals with less neuropathology are common and puzzling.
Clinical observations suggested that gamma-hydroxybutyrate ( GHB ) protects nerve cells against death but the direct proofs are missing.
Clinical outcome and virological data were also assessed as secondary measures.
Clinical outcome measures including symptoms of depression were also compared between patients with vitamin C deficiency and those with normal levels.
Clinical outcomes and histological analysis were performed.
Clinical outcomes at @number@ months were evaluated with the modified Rankin score.
Clinical outcomes improved significantly for all subjects in both groups between endpoints.
Clinical outcomes measured included glycosylated haemoglobin ( HbA1c ) , low-density lipoprotein ( LDL ) , blood pressure and total cholesterol.
Clinical outcomes , such as mortality , were not available.
Clinical outcomes were assessed by ODI scores and JOA questionnaires before and after operation.
Clinical outcomes were observed through photographs with patients in a natural smiling position.
Clinical phenotype of individuals with spinocerebellar ataxia @number@ ( SCA2 ) is characterised by cerebellar ataxia and cognitive impairment.
Clinical photographs demonstrate improvement in the \ "pinched \ " upper face and an apparent elongation of the brows.
Clinical practice guidelines exist for office spirometry basics for safety , use of electronic peak flow devices , and portable spirometers.
Clinical practice guidelines , however , do not take into account potential therapeutic conflicts caused by co-occurring medical conditions.
Clinical practice guidelines inadequately address harmful interactions and resulting therapeutic conflicts within and among diseases.
Clinical practice guidelines need to address frequent therapeutic conflicts in patients with co-morbid medical conditions.
Clinical practice guidelines provide guidance in decision making relating to diagnosis , management , and treatment in specific areas of health care.
Clinical practice has been shown to have an impact on how student nurses perceive a particular field of nursing.
Clinical practice leaders were engaged as partners in the development of the intervention.
Clinical presentation , blood culture , laboratory results , and echocardiography findings were compared between the 1990s and 2000s.
Clinical presentation of IgG4 anti-NF155 antibody-positive patients was consistent with those in previous reports.
Clinical presentations combined dementia with psychiatric symptoms and / or parkinsonism.
Clinical presentations of these acid-related disorders may be atypical in the geriatric population.
CLINICAL QUESTION : Is there evidence that hip protectors and vitamin D with calcium supplementation reduce hip fractures in the elderly ?
CLINICAL QUESTION / LEVEL OF EVIDENCE : Risk , II.
CLINICAL QUESTION / LEVEL OF EVIDENCE : Risk , III.
CLINICAL QUESTION / LEVEL OF EVIDENCE : Therapeutic , II.
CLINICAL QUESTION / LEVEL OF EVIDENCE : Therapeutic , III.
CLINICAL QUESTION / LEVEL OF EVIDENCE : Therapeutic , IV.
CLINICAL QUESTION / LEVEL OF EVIDENCE : Therapeutic , IV.
CLINICAL QUESTION / LEVEL OF EVIDENCE : Therapeutic , IV.
CLINICAL QUESTION / LEVEL OF EVIDENCE : Therapeutic , IV.
CLINICAL QUESTION / LEVEL OF EVIDENCE : Therapeutic , IV.
CLINICAL QUESTION / LEVEL OF EVIDENCE : Therapeutic , IV.
CLINICAL QUESTION / LEVEL OF EVIDENCE : Therapeutic , IV.
CLINICAL QUESTION / LEVEL OF EVIDENCE : Therapeutic , IV.
Clinical ratings and 3D measurements are suitable methods to assess facial wrinkle severity in men and women.
Clinical recommendations based on transparent evaluation are now possible for @number@ variants that were not obviously protein truncating from nomenclature.
CLINICAL RELEVANCE : Enhancing the quality of care for older patients requires an understanding of the challenges and obstacles experienced by nurses.
CLINICAL RELEVANCE : It has been shown that unloading the knee temporarily may induce beneficial effects on osteoarthritis-related structural changes.
CLINICAL RELEVANCE : Many older dental patients will be suffering from medical conditions or taking prescribed or non-prescribed drugs.
CLINICAL RELEVANCE : Meibomian gland dysfunction and evaporative dry eye are common age-related eyelid disorders.
CLINICAL RELEVANCE : Retrieval studies are warranted to determine the natural history of the in vivo oxidation and wear behavior of first-generation , remelted HXLPE.
CLINICAL RELEVANCE : Special interventions should address physical quality of life and physical functioning.
CLINICAL RELEVANCE : The findings offer reference values for physical performance tests specific to community-dwelling frail elderly people.
CLINICAL RELEVANCE : The findings of our study may have implications for increased vulnerability of the gluteus medius tendon and decreased healing potential.
CLINICAL RELEVANCE : The results indicate similar longevity of the chosen materials for veneer restorations.
CLINICAL RELEVANCE : This study will be useful for improving donor site selection during preoperative planning.
Clinical research is needed to identify biological factors responsible for this sex difference.
Clinical response to CZP was observed in approximately two thirds of patients.
Clinical results were not statistically different.
Clinical Review of Systems was used to assess participants ' perceptions of their cardiovascular and pulmonary symptoms.
Clinical scales are widely used in anti-ageing research and practice.
Clinical scores of disability and disease progression were correlated with measures of cortical thickness.
CLINICAL SIGNIFICANCE : Contemporary calcium silicate materials can be used as dentin substitute materials in \ "open sandwich \ " Class II restorations.
CLINICAL SIGNIFICANCE : Fatigue strength of dental ceramics and moisture was shown to affect the mechanical properties of all-ceramic restorations.
CLINICAL SIGNIFICANCE : In fabricating maxillofacial prostheses , mechanically mixing silicone under vacuum produces pore-free prostheses , tending to enhance their color production and stability.
CLINICAL SIGNIFICANCE : L and a values of enamel over white and black backgrounds were statistically different within the @number@ age groups considered.
CLINICAL SIGNIFICANCE : Molar tubes should be cleaned , before and during sliding mechanics , in order to minimize friction.
CLINICAL SIGNIFICANCE : The staining solutions decreased the fluorescence intensity , even when the composite resins were sealed.
Clinical signs and symptoms of these CVDs begin to emerge , however , when the age-associated inflammation in the heart and arteries exceeds a threshold.
Clinical signs , ECG alterations and high troponin I in both patients imposed urgent diagnostic testing and management.
Clinical studies are relatively sparse and so far PDE1-Is and PDE4-Is showed some promising results.
Clinical studies exploring mechanisms involved in the effects of antimuscarinics were included.
Clinical studies find that childhood adversity and stressful life events in adulthood increase the risk for major depression and for suicide.
Clinical studies have assessed fracture risk based on bone quality in the aging population and cadaveric testing has quantified bone strength and fracture loads.
Clinical studies have demonstrated that IPL has significant photorejuvenation effects on photoaged skin.
Clinical studies have demonstrated that Polygonum multiflorum improves hypercholesterolemia , coronary heart disease , neurosis and other diseases commonly associated with aging.
Clinical studies , however , have yielded conflicting results.
Clinical studies should use well-characterized test products , better descriptions of baseline diets , and validated biomarkers of intake and disease risk reduction.
Clinical studies show that aging and hypertension significantly increase prevalence of CMHs.
Clinical studies show that HC continual ingestion helps to reduce and prevent joint pain , bone density loss and skin ageing.
Clinical studies show that plasma HDL cholesterol and apoA-I levels are low in patients with AD.
Clinical studies suggest that the increase in expression of MTBP leads to reduction in survival of breast cancer patients.
Clinical success of use of bioactive glass for bone regeneration is evidence that this concept works.
Clinical symptoms and signs are important keys to detect cortical lesions of neurological disorders.
Clinical symptoms of PD become apparent when 50-60% of nigral dopamine neurons are lost.
Clinical symptoms were evaluated using Numerical Rating Scale for back pain and the Oswestry Disability Index for physical disability.
Clinical translation of this technology , however , depends on the development of systems for effective delivery of the molecular medicine to the target site.
CLINICALTRIAL : Clinicaltrials.gov NCT02016014 ; @url@ ( Archived by WebCite at @url@
Clinical trial data have now demonstrated the benefits of statin treatment in the elderly in both the primary and secondary prevention settings.
Clinical trial data indicate that current treatments for OAB are generally effective and well tolerated in elderly patients.
Clinical trial failures and the therapeutic interventions that have proven successful are also discussed.
Clinical trial number NCT03095196.
Clinical trial registered with www.clinicaltrials.gov ( NCT @number@ and NCT @number@ ) .
CLINICAL TRIAL REGISTER : NCT01511354 on clinicaltrials.gov.
CLINICAL TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT01577030.
CLINICAL TRIAL REGISTRATION : ClinicalTrials.gov : NCT02013466.
CLINICAL TRIAL REGISTRATION : ClinicalTrials.gov , www.clinicaltrials.gov , NCT00325039.
CLINICAL TRIAL REGISTRATION : NCT0038.
CLINICAL TRIAL REGISTRATION : NCT02020863.
CLINICAL TRIAL REGISTRATION : NCT @number@ and NCT @number@
Clinical trial registration number.
CLINICAL TRIAL REGISTRATION NUMBER : NCT01093378.
CLINICAL TRIAL REGISTRATION NUMBER : NCT @number@
CLINICAL TRIAL REGISTRATION URL : Clinicaltrials.gov.
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION : URL : @url@
CLINICAL TRIAL REGISTRATION URL : @url@
CLINICAL TRIAL REGISTRATION- URL : @url@
CLINICAL TRIAL REGISTRATION URL : @url@ Unique identifier : NCT01072500.
CLINICAL TRIAL REGISTRATION URL : www.clinicaltrials.gov Unique identifier : NCT01072500.
Clinical Trial Registration : www.clinicaltrials.gov : CRATUS ( # NCT02065245 ) .
CLINICAL TRIAL REGISTRATION : www.controlled-trials.com ; Unique Identifier : ISRCTN35739639.
Clinical trials are essential to establish a causal link between VitD and cognitive well-being.
Clinical trials are required to elucidate the role of dietary patterns in cognitive aging.
Clinical trials are required to elucidate these effects.
Clinical trials evaluating digoxin use specifically in the elderly are scarce.
Clinical trials for AD are now moving toward these earlier stages of the disease , targeting MCI due to AD and preclinical AD.
Clinical trials for mammography screening , fenretinide chemoprevention and neo-adjuvant chemotherapy show opposite effects in younger and older women.
Clinicaltrials.gov Identifier : NCT00177671.
ClinicalTrials.gov Identifier : NCT00412932.
ClinicalTrials.gov Identifier : NCT00618670.
ClinicalTrials.gov Identifier : NCT00759304.
Clinical Trials.gov.Identifier : NCT00924937.
ClinicalTrials.gov Identifier : NCT01513265.
ClinicalTrials.gov Identifier : NCT01542892.
ClinicalTrials.gov Identifier : NCT02003677.
( ClinicalTrials.gov : NCT00270647 ) SETTING : The Physicians ' Health Study II.
ClinicalTrials.gov : NCT01069445-NCT01179789.
( ClinicalTrials.gov : NCT01314950 ) .
Clinicaltrials.gov : NCT01472393.
ClinicalTrials.gov NCT01527110 ; GSK NAI115215.
ClinicalTrials.gov NCT01597453.
( ClinicalTrials.gov : NCT01650337 ) .
ClinicalTrials.gov NCT02109523.
Clinicaltrials.gov NCT02405975.
CLINICALTRIALS.GOV : NCT02699281.
( ClinicalTrials.gov number , NCT00221923. ) .
Clinical trials.gov number : NCT00964418.
( ClinicalTrials.gov registration number : NCT00123058 ) .
ClinicalTrials.gov registration number NCT01944319.
Clinicaltrials.gov registration numbers NCT00171626 , NCT00171678 , NCT00426621.
ClinicalTrials.gov was searched for natural history studies in GA and clinical trials of drugs targeting the complement cascade for GA.
Clinical trials have demonstrated efficacy of several treatment options available for men with osteoporosis.
Clinical trials have demonstrated that the vaccine decreases the incidence of HZ and post-herpetic neuralgia by up to @percent@ and @percent@ , respectively.
Clinical trials have largely been aimed at removing insoluble beta amyloid in senile plaques and have not reduced soluble load.
Clinical trials have shown that antioxidant supplementation increased the risk of lung and skin cancers , but the underlying molecular mechanism is unknown.
Clinical trials have shown that topically applied ROL effectively reduces wrinkles and helps retain youthful appearance.
Clinical trials have shown the benefits of Membrane Lipid Replacement in restoring mitochondrial function and reducing fatigue in aged subjects and chronically ill patients.
CLINICAL TRIALS INFORMATION : ClinicalTrial.gov identifier for the 24-w drug trial , NCT00419471.
Clinical trials investigating PPI-clopidogrel interactions have provided conflicting results and are all subject to methodological critiques.
Clinical trials of CAVD pharmacotherapy have been carried out based on those histopathologic studies.
Clinical trials of treatments for AD based on anti-amyloid therapy have been unsuccessful.
Clinicaltrials.org NCT01065909.
ClinicalTrials.org ( NCT01805804 ) .
Clinical trials performed in older adults confirm that HMB can attenuate the progression of sarcopenia in elderly subjects.
CLINICAL TRIALS REGISTRATION : ClinicalTrials.gov identifier NCT00000611 .
Clinical Trials Registration : IMPAACT @number@ NCT00028145.
CLINICAL TRIALS REGISTRATION : NCT00455793.
CLINICAL TRIALS REGISTRATION : NCT00803595.
CLINICAL TRIALS REGISTRATION : NCT01122368.
CLINICAL TRIALS REGISTRATION : Trial Number NCT01049698.
Clinical trials report a pronounced incidence of positive symptoms in late-onset schizophrenia.
Clinical trials still rarely incorporate patient-related endpoints , even in trials that specifically address older patients.
Clinical trials targeting network hyperexcitability in patients with Alzheimer's disease will identify whether AEDs or related strategies could improve their cognitive symptoms or slow decline.
Clinical trials using thymopoiesis-stimulating factors are underway.
Clinical trials with new drugs for chronic obstructive pulmonary disease ( COPD ) have been performed.
Clinical variables examined included the Mini-mental State Exam , Hoehn & Yahr stage , and total dopaminergic medication dose.
Clinical variables , including electrocardiogram and troponin I levels , were evaluated to estimate MACEs.
Clinical variables that improved diagnostic accuracy were medication response , motor fluctuations , dyskinesias , and hyposmia.
Clinical VTE and the evidence for the valvular origin of venous thrombosis are reviewed.
Clinician feedback reports summarize discrepancies and provide recommendations for deprescribing.
Clinicians ' age expectations likely influence patients ' expectations and care delivery patterns ; yet , limited research has explored clinicians ' age expectations.
Clinicians and educators should be made aware of the impact that BPD can have on the long-term development of executive functions.
Clinicians and health care systems should develop strategies to provide timely and effective care to this high-risk population of patients.
Clinicians and researchers need to be cautious when choosing testing position for assessing and interpreting grip strength results obtained from these positions.
Clinicians and service providers should consider gender differences when developing strategies for the prevention and treatment of alcohol-related cognitive decline among older adults.
Clinicians and society need to appreciate the extent of deleterious effects of chronic stress on dementia caregiver health.
Clinicians are encouraged to use it to help estimate whether a patient can drive , walk , and cross a street safely.
Clinicians can address many of these issues in addition to providing education and validating women's sexual health concerns.
Clinicians can be assured of normal motor development at @number@ months using the ASQ-3 , but should continue to screen children on other domains.
Clinicians can continue to apply CSMs in endodontic procedures ; however , caution is advised when these materials are applied to thin dentinal walls.
Clinicians caring for disabled older adults should assess their unmet needs and the capacity of caregivers to address them.
Clinicians caring for older adults with an acute COPD exacerbation should also guard against prognostic pessimism.
Clinicians completed the Clinical Global Impression of Severity and Change scales and a clinical form.
Clinicians have an important opportunity to help enhance safe and effective community policing for older adults.
Clinicians have to weigh the risks and benefits of the treatments available to prevent these complications.
Clinicians increasingly are expected to substitute social and economic goals for the needs of a single patient.
Clinicians independently did an extensive assessment , including patient and family interviews and medical record reviews.
Clinicians may consider the mindfulness program as a promising alternative to conventional interventions.
Clinicians may need to question women actively about these symptoms , as many are reluctant to seek help for this problem.
Clinicians may use this tool to evaluate and assess progress in older adults ' power and physical functioning.
Clinicians need easy-to-perform reliable clinical tests such as FTSTS and TUG to assess mobility of aging injection users with venous ulcers.
Clinicians need to attend to aging-related health issues when providing care for prostate cancer survivors to improve QOL.
Clinicians need to be aware of this common condition that could lead to binocular vision problems and potentially cause falls in the elderly.
Clinicians need to consider the association between executive function and physical performance when working to improve physical functioning in an aged population.
Clinicians of the two groups had to complete a specific per group e-learning program in @number@ days.
Clinicians prefer quetiapine for its theoretically better safety profile , although there is no evidence for efficacy in treating psychosis.
Clinicians , public health professionals , and policy makers can play an active role in accelerating the application of such interventions globally.
Clinicians seeing older adults should assess for depression and perceived burdensomeness when determining suicide risk.
Clinicians should anticipate more-frequent sequelae of severe sepsis in their patient populations.
Clinicians should balance the risks and benefits before committing elderly patients to long-term PPI therapy.
Clinicians should be aware of social isolation and loneliness in late life and discuss non-pharmacologic treatment options with their ageing patients.
Clinicians should be aware of these issues when assessing and treating suicide risk among older adults.
Clinicians should be aware that respiratory health often deteriorates during reproductive aging.
Clinicians should be trained to ask older patients about sexual concerns.
Clinicians should consider alternatives with lower anticholinergic effects , particularly in patients already taking DAPs.
Clinicians should encourage seniors to get at least this volume of regular daily exercise.
Clinicians should exercise a high level of vigilance in monitoring the risk of infections in older patients on these treatments.
Clinicians should pay attention to the ability to negotiate stairs in elderly and disabled patients.
Clinicians should prescribe these drugs cautiously and if possible choose safer alternatives for older patients.
Clinicians should provide more education on the importance of older adults moderating alcohol intake.
Clinicians should therefore pay close attention to these factors when evaluating treatment.
Clinicians who care for older adults should screen them annually for falls.
Clinicians who provide cancer survivorship care may improve patient care by understanding the evidence for and against their use.
Clinicians who work closely with these patients should regularly screen and assess older Asian adults for symptoms related to their mental health needs.
Clinicians will most likely have to monitor both clinical and biomechanical characteristics to optimize care.
Clinic manifestation is painless hard and fixed nodule in the subareolar region in @percent@ of cases , with nipple commitment earlier than in women.
Clinicopathological features and pathogenesis of esophageal small-cell carcinoma remain unclear.
Clinicopathological parameters as well as cancer specific survival and overall survival were assessed for correlation with CD66b + TIN density.
Clinicopathologic factors likely to influence outcomes were assessed by univariate and multivariate analysis.
Clinics providing care to YLHIV are varied in terms of the services offered and the types of services offered can impact outcomes , @number@
Clitoridectomy is no optional treatment of ReGS.
Clock drawing is recommended by medical and transportation authorities as a screening test for unsafe drivers.
Clock drawings from @number@ participants were scored independently by four clinical neuropsychologists blind to diagnostic classification.
Clock drawing was measured using four different scoring systems.
Clomiphene is a selective estrogen receptor modulator ( SERM ) that increases the production of gonadotropins by inhibiting negative feedback on the hypothalamus.
Clomiphene is primarily used in the treatment of female infertility for ovulation induction to reverse oligoovulation or anovulation , as occurs in polycystic ovary syndrome.
Clomiphene was initially prescribed at doses between @number@ mg @number@ times a week and @number@ mg / day.
Clonal ∼50 bp deletions in the control region were found at high frequencies in aged specimens.
Clonal evolution patterns of AML were recently dissected and might shape epigenetic dysregulation.
Clonal expansion via reprogramming also enables the discovery of somatic mutations present in individual donor cells , which are missed by bulk sequencing methods.
Clonal hematopoieses after chemotherapy , in marrow failure , and with aging serve as models.
Clonal hematopoiesis can be identified by the presence of somatic mutations in blood or bone marrow even in individuals without a myeloid malignancy.
Clonal hemopoiesis driven by leukemia-associated gene mutations can occur without evidence of a blood disorder.
Clonal relationships are not directly measured , but they must be computationally inferred from these sequencing data.
Clonidine during paediatric ECMO cannot be effectively titrated as PK data are lacking.
Close attention was paid to participation year and tasks performed during the worker's stay in Chernobyl , health status , and RTL differences between subgroups.
Close collaborations between basic scientists and clinical genomicists are now needed to link genetic variants with disease causation.
Closed forms for the pdf , cdf , mode , quantile , and hazard functions ; and @number@
Closed reduction was done and the patient was discharged after two days.
Closed traumatic Achilles tendon rupture is a common injury , especially in the aging athlete.
Close-ended questions were developed on a five-point scale ranging from @number@ = strongly agree to @number@ = strongly disagree.
Close interactions between cardiologists and oncologists are required for the optimal care of many cancer patients.
Closely related to this pathway is the Klotho gene.
Closer co-operation between pulmonologists and cardiologists is necessary to optimize management of this large proportion of CHF patients.
Closer relationship with psychiatrist made early detection and treatment of delirium possible.
Close to half of the participants ( @percent@ ) were employed compared with the @percent@ in @number@
Close to @number@ % of patients were operated within @number@ h with a median time to surgery of @number@ h.
Close vicinity of mtDNA molecule to the source of reactive oxygen species , electron transport chain , potentiates degradation of nucleic acid chemical components.
Clostridium difficile-associated fatality decreased from @percent@ in @number@ to @percent@ in @number@ ( P < @number@ ) .
Clostridium difficile-associated illness is an increasingly prevalent and morbid condition.
Clostridium difficile associated with use of broad spectrum antibiotics mainly affects frail older people and results in prolonged hospital stay with substantial morbidity and mortality.
Closures tended to be spatially clustered in minority-concentrated zip codes around the urban core , often in pockets of concentrated poverty.
Clozapine is associated with serious adverse effects such as agranulocytosis , seizures , myocarditis and metabolic syndrome.
CLR / RAMP2 ( AM₁ receptor ) is more highly AM-specific than CLR / RAMP3 ( AM₂ receptor ) .
CLS was extended in quiescent NHFs that were cultured in the presence of HT for 30-60 days.
Cluster analyses were used to establish behavioral patterns , combining PA and SB.
Cluster analysis and ordinary least squares ( OLS ) regression were performed.
Cluster analysis identified Isolated , Friend-centered , and Integrated social network types.
Cluster analysis of age-corrected sensitivity thresholds revealed unique CSIs for GI-V , with smaller stimuli having a greater number of unique clusters.
Cluster analysis revealed four subgroups of mood-change trajectories.
Cluster analysis revealed the selective presence of hundreds of upregulated and downregulated transcripts.
Cluster analysis showed the presence of two types of glomeruli.
Cluster analysis was used to determine patterns and mean adequacy ratio ( MAR ) to determine adequacy of @number@ micronutrients.
Cluster and discriminant analysis were applied to all neuropsychological test results to distinguish possible subgroups inside each age group.
Cluster and principal components analyses showed that the expression profiles for these genes distinguished WMH + from WMH- subjects.
Clusterin could be informative as part of a multi-component preclinical marker for AD.
Clustering , characteristic path length and small-worldness are key topological measures and they are widely used in literature.
Clustering coefficient and modularity , but not path length , were reduced in AD.
Clustering coefficient of each ROI in relation to the other ROIs are extracted as features for classification.
Clustering of non-viable osteocytes may locally impede the effect of OPG leaving the ghost regions unprotected against focal bone remodeling , as in human otosclerosis.
Clusterin was quantified using ELISA ( mean 255± @number@ ng / ml ) .
Cluster @number@ was labeled as the \ "practical users \ " ( @percent@ , n = 523 ) .
Cluster sampling was used in randomly selected local residents aged no less than @number@ years.
Clusters differed significantly by sex , disease status , and age.
Cluster , stratified and randomly selected sampling technique was used and a follow-up program was carried out in @number@
CMA activity is regulated by starvation , growth factors , oxidative stress , lipids , aging , and retinoic acid signaling.
CMA contributes to maintaining a functional proteome , through elimination of altered proteins , and participates in the cellular energetic balance through amino acid recycling.
CMAP and EMG correlated with given BoNT-A dose and are more defined effect measures than clinical glabellar photo scales.
CMAP reduction correlated well with intramuscular BoNT-A dose.
CMA proteolytic activity has a reciprocal relationship with macroautophagy : CMA is most active in cells in which macroautophagy is least active.
CMBs were observed in @percent@ and incident dementia in @number@ participants ( @percent@ over study period ) .
CMHs are also now recognized by the National Institutes of Health as a major factor in Alzheimer's disease pathology.
CMI occurrence in patients ( @percent@ ) and controls ( @percent@ ) was not significantly different.
CML is a therefore a potentially predictive marker for the treatment of breast cancer patients with tamoxifen or chemotherapy.
CML was not associated with frailty in women.
CM of fetal donors was significantly better than CM of adult or AMD donors at improving the survival of degenerating porcine retina.
CMRglu was unchanged after Walking ( @number@.0±0.1 μmol / 100 g / min ; p = @number@ ) .
CMS also outlined how it will provide incentives for participation in Advanced Alternative Payment Models ( called APMs ) .
CMs are the most numerous cells , representing @percent@ in newborns , @percent@ in children and @percent@ in adults.
CMS received extensive input from stakeholders including the American Geriatrics Society.
CMV IgG level was associated with expansion of senescent CD8 + CD28- T cells and NK cells , which are involved in viral control.
CMV IgG level was inversely correlated with TL.
CMV IgM titers were negative for all @number@ participants , suggesting that recent primary CMV infection was unlikely.
CMV immunoglobulin M ( IgM ) and IgG titers were measured using chemiluminescent assays.
CMV infection further amplified the positive association between ageing and the reactivation rate.
CMV seropositive subjects with high anti-CMV titres were at higher risk for all-cause mortality compared with other individuals.
CMV status did not have a significant impact on any CD4 + T-cell subsets.
CNAs seldom documented behaviors or reported them to nurses.
CNAs who endorsed an EOL care preference of wanting all possible treatments regardless of chances for recovery were likely to report lesser emotional preparedness.
CNK1 acts as a scaffold protein in several signaling pathways controlling the function of FoxO proteins.
CNR in Group1 was the same as in @percent@ of subjects in Group2 and @percent@ of subjects in Group3.
CNS white matter is subject to a novel form of neural plasticity which has been termed \ "myelin plasticity \ ".
CNTNAP4 association with longevity was supported by a marked @percent@ lifespan change in C. elegans after knocking down the ortholog gene.
CNV formation is initiated by the interplay between inflammation , the hallmark of exudative AMD , and the activation of WNT / β-catenin pathway.
CNVs constitute a prevalent source of genomic variations and substantially participate in each individual's genomic makeup and phenotypic outcome.
COACH participants experienced twice the number of positive outcomes that control participants experienced.
Coactivation of the ankle joint was recorded during each task via electromyography ( EMG ) .
Co-administration of testosterone and Odc1 inhibitor presents a novel therapeutic strategy for prostate-sparing anabolic therapy.
Coarsened exact matching creates analytic weights for the matched data sets.
Coarsened exact matching matched exposed and unexposed participants on several sociodemographic factors.
Coats plus is a rare recessive disorder characterized by intracranial calcifications , hematological abnormalities , and retinal vascular defects.
Cobalamin ( vitamin B12 ) deficiency in the elderly is an under recognized problem in daily clinical practice.
Cobalamin ( vitamin B12 ) deficiency is a subtle progressive clinical disorder , affecting nearly @number@ in @number@ individuals > @number@ years old.
Cobalt and nickel induced a concentration-dependent increase of @date@ and HIF-1α , but not NANOG or KLF4.
Cobb angle and DISH relationship was assessed at different spine levels ( thoracic and lumbar ) .
Co- but not pre-treatment with L-carnosine protected differentiated SH-SY5Y cells exposed to SDM.
Cocaine abusers performed more poorly than controls on TMT A ( p < @number@ ) .
Cochlear activity is regulated by the olivo-cochlear bundle , which originates from the brainstem and projects onto the hair cells and auditory nerve fibers.
Cochlear implantation appears to be an effective management strategy for patients with severe-to-profound hearing loss.
Cochlear implantation is increasingly used to treat hearing impairment and to restore the ability to communicate.
Cochlear mRNA samples were collected and cDNA generated.
Cochrane SRs have more comprehensive ROB evaluation than paper-based reviews.
Cockayne is a segmental progeroid syndrome that has autosomal recessive inheritance pattern.
Cockayne syndrome ( CS ) is a rare autosomal recessive disorder characterized principally by progressive growth failure , neurologic abnormality and premature aging.
Cockayne syndrome ( CS ) is a rare genetic disorder characterized by small stature , intellectual disability , and accelerated pathologic aging.
Cockayne syndrome is a neurodegenerative accelerated aging disorder caused by mutations in the CSA or CSB genes.
Cockayne Syndrome is a segmental premature aging syndrome , which can be caused by loss of function of the CSB protein.
Cockayne syndrome presents senescence-like changes starting in early infancy ; however , the mechanism of premature aging remains unclear.
Cocoa is rich in procyanidins , theobromine , ( - ) -epicatechin , catechins , and caffeine.
Cocoa products , which are rich sources of flavonoids , have been shown to reduce blood pressure and the risk of cardiovascular disease.
Co-contractions were assessed as the period of overlap between activation intervals of TA and GL.
COCs ( n = @number@ ) were studied by light and qualitative / morphometric transmission electron microscopy.
Co-culture of fetal RPE and porcine retina was significantly better than fetal RPE-CM at preserving porcine retinal survival.
Codeine is widely used as an analgesic drug.
Codes were grouped into conceptual themes using consensus process.
Codes were grouped into themes about factors that constitute and affect quality of life ( QOL ) .
Coefficient of variation of klotho measurements was @percent@ between Day @number@ and Day @number@
Coefficients ( b ) represent the placebo-controlled mean effect of intervention.
Coenzyme Q10 ( CoQ10 ) acts as both an antioxidant and as an electron acceptor at the level of the mitochondria.
Coenzyme Q10 ( CoQ10 ) , also known as ubiquinone or ubidecarenone , is a powerful , endogenously produced , intracellularly existing lipophilic antioxidant.
Coenzyme Q10 ( CoQ ) is a powerful antioxidant that reduces oxidative stress.
Coenzyme Q ( Q ) is a key lipidic compound for cell bioenergetics and membrane antioxidant activities.
Coexistence of episodes of AF and regular AT occurred in a considerable number of patients ; most of them initially presented with regular AT.
Coexisting associated factors related with frailty in both models were found as depressive mood , cognitive impairment , and malnutrition in multivariate analysis.
Coexisting conditions had an impact on outcomes in elderly soft-tissue sarcoma patients.
Co-expression modules are groups of genes with highly correlated expression patterns.
Coexpression of Dyrk1A and 9G8 led to their translocation from the nucleus to the cytoplasm and suppressed their ability to regulate tau exon @number@ splicing.
Co-expression of SOD suppressed PolyQ-72 induced mitochondrial defects and partially suppressed aggregation as well as myofibrillar disorganization.
Coffea arabica leaves were extracted with methanol , and the extract was hydrolyzed with different concentrations of hydrochloric acid.
Coffee consumption was associated with higher circulating levels of adiponectin and lower circulating levels of leptin.
Coffee has been proposed to have benefits for chronic diseases ; however , the relevant mechanism remains to be elucidated.
Coffee intake was obtained from participant self-reports using the Cornell Medical Index and food frequency questionnaires.
Coffee is the largest source of polyphenols , which supplies a large number of antioxidants in one's daily life.
CO-GHD was acquired in @percent@ , congenital in @percent@ , and idiopathic in @percent@ cases.
Cognition.
Cognition and APOE ε4 carrier status influence the association between Aβ and gait speed in elderly individuals without dementia.
Cognition and cognitive status for patient classification were assessed using detailed neuropsychological testing.
Cognition and living alone were not significantly associated with participation restriction.
Cognition and self management ability were related to medication management capacity.
Cognition arises as a result of coordinated processing among distributed brain regions and disruptions to communication within these neural networks can result in cognitive dysfunction.
Cognition changes may be the only indication of impaired oxygenation.
Cognition had no effect on skilled nursing care.
Cognition has already been considered as a component of frailty , and it has been demonstrated that it is associated with adverse health outcomes.
Cognition is assessed across multiple domains including attention and executive control , language , memory , emotion , action control and learning.
Cognition is important for locomotion and gait decline increases the risk for morbidity , mortality , cognitive decline , and dementia.
Cognition is inseparable from physical activity , with both interlinked to promote neuroplasticity and more successful brain aging.
Cognition is now considered a relevant domain of frailty.
Cognition is one of our most important attributes.
Cognition , mastery and neuroticism were measured using the mini mental state examination , the Pearlin Mastery Scale and the Dutch Personality Questionnaire respectively.
Cognition , @number@ 138-162 ) , which posits that organisms detect invariance patterns in stimuli that are necessary precursors to concept formation.
Cognition showed similar associations with incident loss of the ability to ambulate.
Cognition was assessed by a battery of neuropsychological tests examining memory , attention , visual spatial function , executive function and global cognitive score.
Cognition was assessed by the MMSE , and CD was defined as a decrease of two points or more on the MMSE.
Cognition was assessed in @number@ and 2005-2008.
Cognition was assessed over a 20-year period using the Mini-Mental State Examination.
Cognition was assessed using a battery of five , seven , and four psychometric tests , respectively.
Cognition was assessed using the Cambridge Neuropsychological Test Automated Battery ( CANTAB ) .
Cognition was assessed using the mini mental state depressive symptoms that were assessed using the Geriatric depression scale or cornell scale for depression in dementia.
Cognition was assessed using the Mini Mental Status Examination ( MMSE ) and Montreal Cognitive Assessment ( MoCA ) .
Cognition was assessed with a neuropsychological battery , providing summary scores for memory , language , executive , and visuospatial abilities.
Cognition was assessed with the Mini-Mental State Examination.
Cognition was evaluated using the Mini-Mental State Examination ( MMSE ) .
Cognition was examined using a combined score from word recall , Serial @number@'s , backward counting , and naming tasks.
Cognition was measured by the Mini Mental State Examination.
Cognition was measured using the computerized Cogstate Brief Battery at baseline , 18- , 36- , and 54-month follow-ups.
Cognition was measured with items from the Mini-Mental State Examination in @number@ @number@ or @number@
Cognition was similar in the randomization arms @number@ years after the intervention in @number@ participants , suggesting that the intervention did not benefit cognition.
Cognition was summarized with previously validated factor scores.
Cognitive abilities decline with age and older adults , as a group , are at increased risk for developing age-related cognitive disorders.
Cognitive abilities decline with age , but with considerable individual variation.
Cognitive ability and years of education correlated with several NEO-FFI personality traits in analyses adjusting for demographic variables.
Cognitive ability data across the domains of general ability , processing speed , and memory were available at mean age @number@ years.
Cognitive ability data were available from age @number@ years when the participants completed the Moray House Test No. @number@ ( MHT ) .
Cognitive ability was a stronger predictor for older adults than for younger adults.
Cognitive ability was examined using the Wechsler Adult Intelligence Scale ( Third Edition ) matrices and digit span.
Cognitive ability was not significantly associated with the usage of community-based services.
Cognitive accuracy rate for children and adults was similar for both postures ; however , response latency was greater for children than adults.
Cognitive activities , socialization , and exercise were assessed at baseline , and cognitive function was measured at baseline , 5-year , and 10-year follow-up.
Cognitive activity is thought to provide some protection against dementia , but the mechanism and timing of these effects are unknown.
Cognitive agents are expected to interact with and adapt to a nonstationary dynamic environment.
Cognitive aging is a heterogeneous reality among the senior population.
Cognitive aging research and the design of aging-friendly environments can benefit from paying closer attention to the developmental dynamics and implications of this shift.
Cognitive and behavioral processes are proving to be no exception.
Cognitive and emotional well-being are inextricably linked.
Cognitive and neuropsychological models predict that two types of processing might influence age differences in belief reasoning : executive functioning and social cue detection.
Cognitive assessment also included the ADAScog scale.
Cognitive assessment with virtual reality ( VR ) may have superior ecological validity for older adults compared to traditional pencil-and-paper cognitive assessment.
Cognitive as well as mobility deficits are associated with an increased fall risk.
Cognitive behavioral group therapy ( CBGT ) has in general positive effects on symptoms , distress and avoidance in SAD.
Cognitive capacity was evaluated with the mini-mental state examination ( MMSE ) .
Cognitive capacity was tested using the Mini-Mental State Examination ( MMSE ) .
Cognitive category [ normal , cognitive impairment without dementia ( CIND ) , or dementia ] was assigned by a consensus panel.
Cognitive challenges , such as concurrent cognitive demands or prior cognitive fatigue , have shown to adversely impact neuromuscular fatigue , specifically in younger adults.
Cognitive changes detected in studies that examined healthy older adults were only mild.
Cognitive clusters were associated with distinct demographical and neurobiological characteristics.
Cognitive clusters were associated with distinct demographical and neurobiological characteristics.
Cognitive complaints are common in the geriatric population.
Cognitive consequences of hormonal changes associated with menopause are of scientific interest and of relevance to public health.
Cognitive control and fluency scores did not predict learning problems.
Cognitive control includes higher-level cognitive processes used to evaluate environmental conflict.
Cognitive control is defined by a set of neural processes that allow us to interact with our complex environment in a goal-directed manner.
Cognitive control is thus a double-edged sword - aiding performance on some tasks when fully engaged , and many others when less engaged.
Cognitive control , the ability to limit attention to goal-relevant information , aids performance on a wide range of laboratory tasks.
Cognitive data included composite measures of five different cognitive domains , based on @number@ individual tests.
Cognitive data were related to genetic information.
Cognitive debriefing is an important step in research tool development and a vital component of establishing response process validity evidence.
Cognitive decline , Alzheimer's disease ( AD ) and other causes are major public health problems worldwide.
Cognitive decline and carotid artery atheroma are common at older ages.
Cognitive decline and dementia are a major cause of disability and mortality among older adults.
Cognitive decline and dementia seem to be associated with diminished sexual behavior in older persons.
Cognitive decline and mortality were similar for those with new-onset diabetes and those without diabetes.
Cognitive decline associated with ageing and age-related disorders emerges as one of the greatest health challenges in the next decades.
Cognitive decline , especially the slowing of information processing speed , is associated with normal ageing.
Cognitive decline , however , appears not only in the psychiatric population but also in aged individuals.
Cognitive decline impacts older adults , particularly their independence.
Cognitive decline in older adults is a major public health problem and can compromise independence and quality of life.
Cognitive decline in older persons can be pathologic or occur as a part of the normal aging process.
Cognitive decline is a burdensome extra-motor symptom associated with Parkinson's disease ( PD ) .
Cognitive decline is of particular importance , as good medical care requires considerable cognitive function.
Cognitive decline is rapidly becoming an important cause of disability worldwide and contributes significantly to increased mortality.
Cognitive decline is very common in age and particularly in subjects with neurodegenerative conditions.
Cognitive decline measured with MMSE remained unrelated to the number of diseases present at baseline.
Cognitive declines across all factors in AD and PD dementia accelerated several years prior to clinical dementia diagnosis.
Cognitive decline was assessed using repeated Modified Mini Mental State Examination scores over the study.
Cognitive decline was defined as the decrease of Mini-Mental State Examinations scores during the study period.
Cognitive decline was defined by calculating the Reliable Change Index using the Mini-Mental State Examination.
Cognitive decline was found in @date@ probands.
Cognitive deficits are common in older adults , as a result of both the natural aging process and neurodegenerative disease.
Cognitive deficits , on the other hand , are associated with worsening gait.
Cognitive deficits ( ranging from @number@ to @percent@ , depending on the screening instrument ) and behavioral changes ( @percent@ ) were frequently detected.
Cognitive diagnosis was made by an expert consensus panel based on published criteria.
Cognitive dimension of social capital was assessed.
Cognitive disorders of aging represent a serious threat to the social and economic welfare of current society.
Cognitive dispersion was calculated by measuring within-person variability in cognitive domains , established through principal components analysis.
Cognitive domains assessed were attention / executive function , language , and memory.
Cognitive domain scores are z-scores calculated using the mean and SDs of the AD group.
Cognitive dysfunction and memory loss are common features of Alzheimer's disease ( AD ) .
Cognitive dysfunction syndrome is underdiagnosed and affects a substantial portion of aged companion animals.
Cognitive efficiency was assessed on the three occasions through episodic verbal memory , attention and processing speed tests.
Cognitive evaluation should take into account sociodemographic information and cultural factors to avoid misdiagnosis and guide management.
Cognitive event-related potentials ( ERPs ) measure synchronized synaptic neural activity associated with a cognitive event.
Cognitive factors were extracted via principal component analysis ( PCA ) .
Cognitive fatigue was induced by sustained performance on cognitively demanding tasks ( compared to a control condition ) .
Cognitive fatigue was operationally defined as decline in alerting , orienting , and executive attention performance over the course of the ANT.
Cognitive frailty has been considered as a subtype of frailty.
Cognitive frailty is the simultaneous clinical manifestation of both physical frailty and cognitive impairment.
Cognitive function after @number@ y of supplementation was assessed with the French version of the modified Telephone Interview for Cognitive Status.
Cognitive function and functional performance were also assessed.
Cognitive function and reserve , semantic memory , and pre-morbid intelligence are assessed.
Cognitive function assessment included short term-working memory , perceptual abilities , processing speed , cognitive inhibition and flexibility and long-term verbal memory.
Cognitive function does not appear to be associated with muscle size.
Cognitive functioning scores were significantly decreasing with increasing levels of kidney dysfunction markers.
Cognitive functioning was assessed at both waves so that change in cognitive status was examined over time , and cognitive status was controlled at baseline.
Cognitive functioning was assessed at both waves using the Short Portable Mental Status ( SPMSQ ) .
Cognitive functioning was assessed during the household interview using a version of the Digit Symbol Substitution Test of the Wechsler Adult Intelligence Scale III.
Cognitive functioning was assessed using the brief Short Portable Mental Status Questionnaire scale.
Cognitive functioning was assessed with tests in the domains of executive functioning , information processing speed , memory , and attention / working memory.
Cognitive functioning was assessed with the Mini-Mental State Examination ( MMSE ) , the Coding Task , and the Raven's Coloured Progressive Matrices.
Cognitive functioning was better in Latinas who read and did puzzles.
Cognitive function is an important component of aging and predicts quality of life , functional independence , and risk of institutionalization.
Cognitive function is multidimensional and complex , and research in multiple species indicates it is considerably impacted by age and gonadal hormone milieu.
Cognitive function itself may bias diet assessment methods , subsequently obscuring the evaluation of the nutrition-cognition relationship.
Cognitive function may be influenced by education , socioeconomic status , sex , and health status.
Cognitive function , mood , and blood pressure were assessed at baseline and follow-up by using standardized validated tests.
Cognitive function , social identification , home satisfaction , and lounge use were measured before and after the intervention.
Cognitive function status was evaluated by the Montreal Cognitive Assessment ( MoCA ) screen test.
Cognitive functions were assessed before and immediately after the interventions , and at 1-year follow-up.
Cognitive functions were assessed by Mini Mental State Examination ( MMSE ) .
Cognitive functions were assessed by the Wechsler adult intelligence scale-revised ( WAIS-R ) in @number@ elderly ( 60 years ) females without dementia.
Cognitive functions were evaluated on the basis of the mini-mental state exam ( MMSE ) .
Cognitive function test scores in verbal memory were positively correlated with percentage of sleep duration with less than @percent@ of oxygen saturation during sleep.
Cognitive function was also measured using attention span and immediate and delayed memory recall tests.
Cognitive function was assessed at 3-y intervals on the basis of a composite measure of global cognition.
Cognitive function was assessed at @number@ standardized examinations using the Cognitive Abilities Screening Instrument ( CASI ) .
Cognitive function was assessed before and @number@ week after surgery.
Cognitive function was assessed by Mini-Mental State Examination.
Cognitive function was assessed by tests from Consortium to Establish a Registry for Alzheimer's Disease ( CERAD ) battery and other.
Cognitive function was assessed by the Alzheimer's Disease Assessment Scale-Cognitive ( ADAS-Cog ) .
Cognitive function was assessed by the Community Screening Instrument for Dementia ( CSI-D ) .
Cognitive function was assessed by the Japanese version of Mini Mental State Examination ( MMSE ) at all visits.
Cognitive function was assessed by using the Modified Mini-Mental State Examination ( 3MS ) ≤4 times over @number@ y.
Cognitive function was assessed using a standard clinical battery focused on executive function and memory.
Cognitive function was assessed using a standardized global cognitive score and BMI was assessed at baseline and classified as normal , overweight , and obese.
Cognitive function was assessed using measures of long-term and working memory , processing speed , reasoning , and verbal ability.
Cognitive function was assessed using the Chicago Cognitive Function Measure ( CCFM ) for @number@ participants.
Cognitive function was assessed using the Digit Symbol Substitution Test ( DSST ) .
Cognitive function was assessed using the Korean version of modified Mini-Mental State Examination ( K-mMMSE ) in @number@ Koreans aged 45-74 years in Namwon City.
Cognitive function was assessed using the Mini-Mental State Examination ( MMSE ) and clock drawing test ( CDT : command and copy ) .
Cognitive function was assessed via a validated Mini-Mental State Examination ( MMSE ) .
Cognitive function was assessed with a battery of neuropsychological tests.
Cognitive function was assessed with a modified version of the Telephone Interview for Cognitive Status.
Cognitive function was assessed with standardized fluency and recall measures.
Cognitive function was assessed with the Mini-Mental State Examination ( MMSE ) .
Cognitive function was assessed with the Mini-Mental State Examination ( MMSE ) in both the second and seventh ( 2010-2012 ) waves.
Cognitive function was evaluated by the Instrument of Brief Neuropsychological Assessment and Mini-Mental State Examination inventory.
Cognitive function was evaluated by the Montreal Cognitive Assessment ( MoCA ) .
Cognitive function was evaluated using a comprehensive battery of standardized neuropsychological tests at baseline and @number@ weeks.
Cognitive function was genetically related to pulmonary function.
Cognitive function was indexed using the Alzheimer Disease Assessment Scale-Cognitive-Plus ( ADAS-Cog Plus ) .
Cognitive function was measured at all three assessments by the Mini Mental State Examination.
Cognitive function was measured at baseline with the mini-mental state examination ( MMSE ) .
Cognitive function was measured based on Telephone Interview for Cognitive Status-Health and Retirement Study version scores.
Cognitive function was measured by the Mini-Mental State Examination before surgery , at hospital discharge , @number@ and @number@ months after discharge.
Cognitive function was measured using the Japanese version of the Montreal Cognitive Assessment ( MoCA-J ) .
Cognitive function was measured with the Trail Making tests A ( TMTA ) and B ( TMTB ) and the Grooved Peg Board test.
Cognitive impairment alone without physical disability did not increase mortality risk in this population.
Cognitive impairment and aspiration pneumonia , but not cerebrovascular disease , were also correlated with a reduced improvement of FIM scores.
Cognitive impairment and dementia are characterized by a progressive and devastating reduction in most cognitive abilities , functional independence , and social relationships.
Cognitive impairment and fear of falling are risk factors for falls in older adults.
Cognitive impairment , even in the absence of manifest dementia , is an important independent predictor of mortality.
Cognitive impairment in schizophrenia may combine with cognitive decline associated with normal aging to reduce practice effects in older patients.
Cognitive impairment is a common and disabling problem in Parkinson's disease ( PD ) .
Cognitive impairment is a core element shared by a large number of different neurological and neuropsychiatric diseases.
Cognitive impairment is a devastating condition commonly observed with normal aging and neurodegenerative disorders such as Alzheimer's Disease ( AD ) .
Cognitive impairment is an important hallmark of dementia , but deterioration of cognition also occurs frequently in non-demented elderly individuals.
Cognitive impairment is one of the most abundant age-related psychiatric disorders.
Cognitive impairment is prevalent in heart failure ( HF ) , though substantial variability in the pattern of cognitive impairment is found across studies.
Cognitive impairment , reduced perceived health , recent hospital stay and receiving meals-on-wheels were factors associated with being at risk for malnutrition.
Cognitive impairments are often related to aging and micronutrient deficiencies.
Cognitive impairments in patients with mild cognitive impairment ( MCI ) and patients with organic brain lesions were significantly improved with ARA and DHA supplementation.
Cognitive impairment suspicion was the only frailty marker that predicted ED visits ( odds ratio @number@ 95%CI @number@.14-21.69 ) .
Cognitive impairment was also associated with poor performance , whereas a history of allergies or a deviated septum was associated with better performance.
Cognitive impairment was a mortality predictor only for NHW.
Cognitive impairment was defined as a CASI score < 74.
Cognitive impairment was defined as a MMSE < @number@
Cognitive impairment was defined as an abnormal result in Mini Mental State Examination.
Cognitive impairment was defined as a score less than @number@ on the Mini-Mental State Examination.
Cognitive impairment was defined as a score of less than @number@
Cognitive impairment was defined as having the score of the Mini Mental State Examination lower than @number@
Cognitive impairment was measured based on the Korean version of the Mini-Mental State Exam score.
Cognitive impairment without dementia may be seen in @percent@ to @percent@ of adults older than @number@ years , and is associated with significant emotional distress.
Cognitive improvement was numerically larger in the combination treatment group than under galantamine alone.
Cognitive intervention is a noninvasive therapy that could aid prevention and treatment of AD.
Cognitive load dual-task gait assessment may provide a cost efficient and sensitive measure to detect older adults at high risk of a dementia disorder.
Cognitive load was assessed by means of pupillometry ( i.e. , examination of pupil dilation ) , supplemented with subjective ratings.
Cognitively , aging is associated with slowing of processing and memory loss.
Cognitively driven responses including response inhibition were impaired in the patient group.
Cognitively healthy middle-aged participants classified as monolinguals ( n = @number@ n
Cognitively impaired ALS patients showed cortical thinning in regions largely overlapping with those found in ALS-FTD , but changes were less widespread.
Cognitively impaired and cognitively intact older adults seemingly differ regarding engagement in aspects of advance care plans ( ACPs ) .
Cognitively impaired individuals generally have poorer baseline performance and greater dual task-related gait velocity reduction than those who are cognitively healthy.
Cognitively impaired participants may encounter difficulties in opening and removing medication from Venalink® and Nomad®.
Cognitively intact participants , ages 65-85 at study entry , underwent repeat anatomical MRI scans on three occasions : baseline , @number@ and @number@ years.
Cognitive measures from six domains of function were administered at baseline and follow-up @number@ months later.
Cognitive modeling analysis indicated that older adults were more likely to forget about recent outcomes and were more consistent than children when selecting decks.
Cognitive neuroscience has revealed aging of the human brain to be rich in reorganization and change.
Cognitive neuroscience literature suggests a strong dissociation between the ability to mentally transform object and body stimuli ( Hegarty & Waller , @number@ ) .
Cognitive outcomes of midlife hormone exposures are less well studied.
Cognitive outcomes were standardized composite measures of verbal episodic memory , executive functions , and global cognition.
Cognitive performance and memory are significantly diminished when occurring out of phase with natural circadian rhythms.
Cognitive performance and self report cognitive and affective symptoms did not differ between groups.
Cognitive performance is compromised in Neurofibromatosis type @number@ ( NF1 ) patients , but neuropsychological data including elderly NF1 are extremely sparse.
Cognitive performance is known to change over age @number@ especially processing speed.
Cognitive performance measures showed the odds of ISH @number@ times higher for older adults with moderate to severe cognitive impairment.
Cognitive performance on four factors was also available : verbal , spatial , memory , and speed.
Cognitive Performance Scale @number@ enables repeated assessments , sensitive to detect changes particularly in early levels of cognitive decline.
Cognitive Performance Scale @number@ extends the measurement metric from a range of @number@ to @number@ for the original CPS , to @number@ to @number@
Cognitive performance tests assessed global function , executive function , processing speed , memory , and attention from which z-scores were computed.
Cognitive performance was assessed in @date@ using six neuropsychological tests , and a composite cognitive score was computed.
Cognitive performance was assessed in up to @number@ waves of in-person testing covering a period of @number@ years.
Cognitive performance was assessed pre-operatively and @number@ months postoperatively.
Cognitive performance was assessed through the mini mental state examination ( MMSE ) .
Cognitive performance was assessed using accuracy ratio : [ correct responses ] / [ total responses ] .
Cognitive performance was evaluated by the use of the Montreal Cognitive Assessment ( MoCA ) .
Cognitive performance was evaluated using the California Verbal Learning Test ( CVLT ) , Digit Symbol Substitution Tasl ( DSST ) and fluency test.
Cognitive performance was evaluated using the Mini Mental State Examination ( MMSE ) ; a cutoff of @number@ was used to diagnose cognitive impairment.
Cognitive performance was evaluated with a 12-test battery assessing episodic , semantic , and working memory , perceptual speed , and visuospatial abilities.
Cognitive performance was measured at baseline and after @number@ weeks by means of a sensitive neuropsychological test battery.
Cognitive performance was measured in two main domains : verbal memory and psychomotor speed.
Cognitive performance was measured through neuropsychological assessments performed at baseline and 6months after initiation of therapy.
Cognitive performance was measured using a composite test score of global cognitive function ( range 0-27 ) .
Cognitive performance was measured using the Montreal cognitive assessment ( MoCA ) score.
Cognitive performance was measured with the Consortium to Establish a Registry for Alzheimer's Disease ( CERAD ) -Plus test battery.
Cognitive processing speed , hearing acuity , and audio-visual ( AV ) experience have been suggested to influence AV asynchrony detection.
Cognitive psychologists posit several specific cognitive abilities that are measured with sets of cognitive tasks.
Cognitive reappraisal partially mediated the effect of age on positive emotions.
Cognitive rehabilitation and physical therapy are the mainstays of dementia treatment , although often ineffective because of the scarce collaboration of the patients.
Cognitive remediation ( CR ) improves cognition in individuals with schizophrenia.
Cognitive reserve , broadly conceived , encompasses aspects of brain structure and function that optimize individual performance in the presence of injury or pathology.
Cognitive reserve ( CR ) and brain reserve can be a good predictive model for AD development.
Cognitive reserve ( CR ) is defined as the ability to maintain functionality despite accumulating pathology.
Cognitive reserve ( CR ) refers to how flexibly and efficiently the individual makes use of available brain resources.
Cognitive reserve is influenced by demographic , environmental and genetic factors.
Cognitive reserve may allow for more flexible strategy usage , an ability thought to be captured by executive functions tasks.
Cognitive reserve scores were positively associated with AxD exclusively in the CN Aβ42 + group.
Cognitive scores declined less among men with greater SWS duration.
Cognitive skills , such as processing speed , memory functioning , and the ability to divide attention , are known to diminish with aging.
Cognitive state was quantified using the Mini-mental State Examination ( MMSE ) and depression with the Geriatric Depression Scale ( GDS ) .
Cognitive status , as determined by standard psychometric tests of fluid cognitive abilities , was unrelated to longitudinal change in subjective well-being.
Cognitive status ( control , mild cognitive impairment , dementia / AD ) was assessed at follow-up.
Cognitive status did not alter results , although participants with lower scores on the Montreal Cognitive Assessment were slower overall.
Cognitive status ( Modified Mini-Mental State Examination ) and depressed mood ( five-item mental health screening questionnaire ) were also assessed.
Cognitive status , motor performance and learning , and motor cortex excitability in response to cathodal transcranial direct current stimulation ( ctDCS ) were assessed.
Cognitive status ranged from normal to demented and AD neuropathology ranged from none to severe.
Cognitive status was determined by the mini-mental state examination and geriatric depression scale.
Cognitive status was evaluated using standard neuropsychological assessments.
Cognitive status was measured by the Mini Mental State Examination ( MMSE ) .
Cognitive status was measured using the Mini-Mental State Exam Blind Version ( range , 0-22 ) which excludes eight items that rely on vision.
Cognitive status was operationalized with the Clinical Dementia Rating ( CDR ) scale.
Cognitive stimulation can delay memory loss during aging and in patients with mild cognitive impairment.
Cognitive tasks impact postural control when performed concurrently as dual-tasks.
Cognitive tasks were performed between 30min and 2h after caf or decaf administration.
Cognitive test scores were the major outcome factors.
Cognitive tests included reasoning , memory , verbal fluency , and vocabulary assessed three times over @number@ years.
Cognitive tests were repeated in 2002-2004 and 2007-2009.
Cognitive training and physical activity seem promising.
Cognitive training for persons with mild cognitive impairment ( MCI ) has become a hot topic.
Cognitive training has been shown to be effective in improving cognitive functions in patients with Mild Cognitive Impairment ( MCI ) .
Cognitive training may stimulate neuroplasticity thereby increasing cognitive and brain reserve.
Cognitive training only attenuated decline in Memory Domain at @number@ months ( P < @number@ ) .
Cognitive training , physical activity , and exercise have often been reported to improve cognitive performance in older adults.
Cognitive training was not associated with changes in hippocampal volume.
Cognitive variables measured phonemic and semantic fluency , attention , verbal memory , and global cognition.
Cohen κ statistics were calculated for interrater agreement.
Coherence-performance maps were generated to further explore topographical differences in the relationship between coherence and performance across groups.
Coherence showed higher bilateral coupling for ET but no differences in inter-limb coupling between PD and healthy subjects.
Coherence thresholds decreased as dot contrast increased asymptoting at high dot contrasts but were higher in elderly compared to young participants.
Coherent cumulative evidence obtained worldwide show that early surgery in asymptomatic patients is the preferred approach.
Cohesin loss may be amplified by a concomitant decline in the levels of the centromeric cohesin protector Sgo2.
Cohesive failure within the PLVs was the most common mode of failure.
Cohort- and sex-specific ANCOVA was used to calculate multivariable-adjusted mean BMD for estimated NEAP and PRAL quartiles.
Cohort differences in P62 and P65 remained after controlling for covariates.
Cohort differences in SRH were modest ( p = @number@ ) , but there was a significant period effect ( p = @number@ ) .
Cohort differences in the employment consequences of poor health are not likely to be caused by poorer work ethics among younger cohorts.
Cohort differences were observed for Extraversion and Openness.
Cohort effect and survivor bias may provide a partial explanation for this phenomenon.
Cohort effects indicated lower level of self-transcendence and higher level of self-directedness and cooperativeness in younger birth cohorts.
Cohort effects were highly significant ( p < @number@ ) .
Cohort life expectancy takes future mortality improvements into account , unlike period life expectancy , leading to a higher prospective potential support ratio.
Cohort @number@ achieved @number@ month median duration.
Cohort @number@ consisted of @number@ living subjects who had @number@ or more OGTTs and underwent brain 11C-PiB positron emission tomography.
Cohort replacement effects explain the increase in depression in Belgium.
Cohorts 1-3 received escalating doses of RT002 ranging from half the equivalent dose of approved toxins up to twice the current dose levels.
Cohorts born in @number@ to @number@ will live longer than one can expect by looking at respective period mortality patterns.
Cohort-specific analyses were conducted using Cox proportional hazards models with a standardized protocol.
Cohort-specific interaction analyses showed significant interactions between the CRY1 variant and dietary carbohydrates for insulin resistance in both populations ( p < @number@ ) .
Cohorts with comprehensive neuropathological assessments and multimodal biomarkers are needed to characterize independent predictors for the different neuropathological substrates of cognitive impairment.
Co-immunoprecipitation experiments demonstrated that crosslinked p62 oligomers retain their ability to bind to LC3 but show defective binding to polyubiquitinated proteins.
Coincident diverticulosis and herniae support this hypothesis.
Coincident with their economic concerns , participants perceived an increase in workplace stress , but not physical demand.
Coincubating Aβ42 together with clusterin , an amyloid-associated protein highly expressed in capCAA-affected vessels , strongly reduced levels of P-gp.
Co-infection was found in @percent@ of patients , of which @percent@ were up to six months of age.
Coinfection with HIV accelerates the progression to end-stage liver disease.
Co-infusion of ACh with BQ-123 resulted in an approx.
Coinhibition is exploited by prostate cancer as an immune evasion pathway.
Co-inhibition of tankyrase @number@ and telomerase activity may be a rational strategy for telomere-directed gastric cancer therapeutics.
Co-IP experiments confirmed the physical interaction of COH1 with RAB6 that preferentially occurred with the constitutively active RAB6 Q72L mutants.
Coital and masturbation frequencies decreased with age , and a significantly greater number of younger men were engaged in masturbation.
COI was in downward trend from @number@ billion yen in @number@ to @number@ billion yen in @number@
COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa.
Cold-activated BAT was detected in @percent@ of the subjects ( BAT-positive ) .
Cold soak had no effect on perceived aroma , bitterness , astringency , and body of the wines.
Cold soak had no effect on the basic chemical composition of the wines.
Cold to cool temperature also adversely affects the EMG.
Collaboration between adult and pediatric practitioners is encouraged to facilitate smooth transitions to health practitioners , including physical therapists.
Collaboration with PC unit was established.
Collaboration with similar study groups in Europe and Asia will be pursued.
Collaborative recall was completed in groups of three individuals working together.
Collagen content and cell proliferation were also determined. mRNA levels of several target genes were measured after one or seven days.
Collagen content and intensity histogram were computed from the optical images.
Collagen content and solubility was determined.
Collagen content was quantitatively determined from thresholded collagen images.
Collagen crosslinking is a posttranslational modification of collagen molecules and plays important roles in tissue differentiation and in the mechanical properties of collagenous tissue.
Collagen degradation was identified from the surface of dentin slabs that were in direct contact with CSMs.
Collagen fibers were thicker but sparser in the adventitia of aortas with AAA.
Collagen fibrils become resistant to cleavage over time.
Collagen hydrolysate is a well-known dietary supplement for the treatment of skin aging ; however , its mode of action remains unknown.
Collagen-I , elastin and involucrin syntheses in human dermal fibroblasts or keratinocytes were up regulated by AAN-II.
Collagen is a major component of extracellular matrix and its modifications accumulate with age.
Collagen is degraded by MMP-1 activity but synthesized by transforming growth factor-β ( TGF-β ) signal.
Collagen is the most abundant protein in mammals and has great tensile strength.
Collagen IV immunostaining revealed vascular proliferation and atypical ductular reaction at the portal-septal parenchymal borders , as well as capillary-like vessels in the lobular parenchyma.
Collagen orientation was assessed using polarized light , whereas inflammasome proteins were quantified by immunoblotting.
Collagen oxidation appears to be a key determinant of aging and a critical physiopathologic mechanism of numerous diseases.
Collagens and hyaluronic acid have long been used in pharmaceuticals and food supplements for the improvement of skin elasticity and hydration.
Collagens are major constituents of connective tissues in the animal kingdom.
Collagens in hybrid layer were less degraded in the groups using E-64 after aging treatment than control group.
Collagens IV and V were immunoexpressed in the vessels endothelium of the lamina propria and in the basement membrane.
Collagen solubility was the largest discriminant between the three age groups , while animal age had no significant effect on collagen content.
Collagen type I expression in fibroblasts was greater with racemic versus S-equol treatment at @number@ and @number@ nM.
Collagen types I and III ( pepsin digestible collagen fraction ) were isolated from the veins of @number@ patients by proteolysis.
Collagen was quantified by hydroxyproline assay and AGEs by the AGE intrinsic fluorescence.
Collagen XXVIII is the last discovered member of the collagen superfamily and thus has been only sparsely investigated.
Collapse of protein homeostasis results in protein misfolding cascades and the accumulation of insoluble protein fibrils and aggregates , such as amyloids.
Collected sperm were treated with CFTR inhibitor or potentiator.
Collecting and analyzing data for improving care quality and undertaking research is a central aim of the partnership.
Collecting sexual orientation and gender identity data in larger , US-based probability samples would inform the development of appropriate community-based services and supports.
Collecting the data and results from the questionnaire will help us understand the initiation events in melanoma and prevention health issues.
Collection of up to @number@ mL of CSF appears to be well tolerated and safe.
Collective advocacy and policy advances are needed to create a national infrastructure to protect the vulnerable older adults.
Collectively , AdMSCs may contribute to anti-wrinkle effects in skin but further experiments are needed to identify the mechanism.
Collectively , aging of the immune system may produce detrimental consequences on the response against tumours in old patients.
Collectively , awardees reached more than @number@ learners.
Collectively , modulation of orexin and its effects on sleep appear to modulate Aβ pathology in the brain.
Collectively , ncRNAs affect a broad range of age-related physiologic deteriorations and pathologies , including reduced cardiovascular vigor and age-associated cardiovascular disease.
Collectively , ( @number@ ) F-AV-133 could be a promising and better tracer for clinical use to detect monoaminergic terminal reduction in PD patients.
Collectively , our data implies the potential for a coating platform for microfluidic devices in many blood-contacting applications.
Collectively , our data provide new insights regarding the role of Mfn2 in controlling cellular proliferation.
Collectively , our data show that reduced KC Par3 function fosters a permissive P-cadherin-dependent niche for MC transformation , invasion , and metastasis.
Collectively our data suggest a link between Shh pathway activity and the physiological properties of mitochondria in hippocampal neurons.
Collectively , our data suggest a novel mechanism for MEK1 in regulating the sensitivity to TGF-β signaling by stabilizing TβRII.
Collectively , our data suggests an additional and novel lipid-mediated mechanism of action for spermidine-induced autophagy.
Collectively , our data suggest that secreted AS exerts toxicity through engagement , at least in part , of the Ca2 + homeostatic machinery.
Collectively , our findings highlight the importance of TDP-43-mediated InSAC biogenesis in immune regulation.
Collectively , our results indicate that butein suppresses the osteoclastogenesis induced by tumor cells and by RANKL , by suppression of the NF-κB activation pathway.
Collectively , our results suggest that the intestinal microbiota becomes altered with a GE diet before induction of tumor.
Collectively , our work demonstrates that EI24 is an essential player in UPS-autophagy crosstalk via degradation of RING E3 ligases.
Collectively @percent@ of familial and 3-5% of sporadic form of PD are associated with genetic mutation.
Collectively , the data in this study indicate that the nonsense nucleotide substitution in the Oca2 gene underlies the Oca2 ( p ) allele.
Collectively , the data suggest that HSJ1a acts on mutant SOD1 through a combination of chaperone , co-chaperone and pro-ubiquitylation activity.
Collectively , the findings indicate that estrogen directly acting on OX62 + DCs , may affect CD4 + lymphocyte-dependent immune response in aged female rats.
Collectively , the functions of p53 contribute to the prevention of malignant and other diseases and decelerate the aging process.
Collectively , the recent studies show the importance of the microbiota and associated metabolites in healthy aging and the importance of diet in its modulation.
Collectively , the results suggest an association between DNA maintenance and decline in cognitive function.
Collectively , these data demonstrate that Rorβ regulates known osteogenic pathways , and may represent a novel therapeutic target for age-associated bone loss.
Collectively , these data indicate that an age-associated increase in miR-29 corresponded with the reduction of @number@ important regulators of microglia , IGF-1 and CX3CL1.
Collectively , these data indicate that autophagic gridlock contributes to the development of pathology in aging and neurodegeneration.
Collectively , these data indicate that deregulated GAPDH expression promotes NF-κB-dependent induction of HIF-1α and has a key role in lymphoma vascularization and aggressiveness.
Collectively , these data indicate that Nox5 is expressed at functionally relevant levels in the human prostate and clinical PCa.
Collectively , these data provide a rationale for mechanism-guided adjuvant tumor therapies.
Collectively , these findings confirm and extend previous observations suggesting that disturbances in peroxisomal redox control and metabolism can sensitize cells to oxidative stress.
Collectively , these findings demonstrate a role for Mbnl1 in controlling insulin receptor exon @number@ inclusion via binding to a downstream intronic enhancer element.
Collectively , these findings demonstrate the feasibility of assessing cerebrovascular impedance using the noninvasive method developed in this study.
Collectively , these findings highlight ROCK2 as a mechanism-based therapeutic target to combat Aβ production in AD.
Collectively , these findings highlight the contribution of the systemic inflammatory status in the age-related decline in skeletal muscle function.
Collectively , these findings identify KLF4 as a nodal transcriptional regulator of mitochondrial homeostasis.
Collectively , these findings indicate that obesity-driven inflammation elevates Wnt-signaling in mammary tissue and thereby creates a microenvironment conducive to the development of breast cancer.
Collectively , these findings indicate that SOX5 is a novel candidate gene for LOAD with an important role in neuronal function.
Collectively , these findings link age-related structural differences to age-related functional under- as well as overrecruitment.
Collectively , these findings provide evidence of preserved hippocampal functioning in normal aging.
Collectively , these findings provide unambiguous evidence that the capacity to remember sequences of events is fundamentally affected by typical aging.
Collectively , these findings suggest that training and engagement models may offer alternative routes to cognitive resilience in late life.
Collectively , these findings support the hypothesis that CNS and peripheral apoE are separate pools and differentially regulated.
Collectively , these five loci explain @number@.0%-3.2% of the variation in retinal venular caliber.
Collectively , these indicate the brain region specificity of the genetic regulation of SORL1 expression.
Collectively , these methods have revealed human brain specializations with respect to development , cortical organization , connectivity , and aging.
Collectively , these new studies are revealing a previously uncharacterized aging phenotype : the accumulation of clones with cancer driver mutations.
Collectively , these phenomena constitute aging and / or certain disease states.
Collectively , these recent advances could inspire the scientific community to explore new biotherapeutic strategies.
Collectively , these results demonstrate the feasibility of using our pipeline for marker discovery and our MRM-MS platform for verifying potential biomarkers of human diseases.
Collectively , these results indicate that ALA increases hepatic FGF21 expression via up-regulation of CREBH , identifying ALA as a novel positive regulator of FGF21.
Collectively , these results indicate that triolein could act as a photoprotective agent.
Collectively , these results partially support the multiprocess theory prediction that aging spares spontaneous retrieval processes.
Collectively , these results provide biological insight into aging and associated homeostatic mechanisms that maintain normal brain function with advancing age.
Collectively , these results provide new insights into the complex nature and dynamics of the naive T-cell compartment.
Collectively , these results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15 ( INK4B ) locus.
Collectively , these results suggest more depth in women's swimming than marathon running.
Collectively , these results suggest that age-related source memory deficits may be primarily due to changes in material-independent contextual binding processes.
Collectively these results suggest that the genotype-survival advantage of the KL-VS allele is age-dependent and possibly mediated through differential cognition and brain volume.
Collectively , these results suggest the occurrence of novel-secreted factors regulating MSC cellular senescence of potential importance for regenerative medicine and cancer therapy.
Collectively , these secular changes have created an obesogenic environment that can unmask diabetes in subjects with a genetic predisposition.
Collectively , they tune metabolic processes to energy availability , and modulate stress responses , protein aggregation , inflammatory processes , and genome stability.
Collectively this analysis indicates that DJ-1 plays an important role in protecting photoreceptors and RPE from oxidative damage during aging.
Collectively , this first GWAS of allopurinol response demonstrates that ABCG2 is a key determinant of response to the drug.
Collectively , this study demonstrated the feasibility of curing genetic disease in human somatic cells and embryos by base editor system.
Collectively , this study identifies connections between the nucleolus , 3D genome structure , and cellular aging at the level of interphase chromosome organization.
Collectively , this study suggests that hyperactivation of the mTOR pathway is involved in the development of endometrial hyperplasia in aged women and mice.
Collectively , this supports the use of the aged dog as a model for examining early pathological events in the development of Alzheimer's disease.
Collectively , this work demonstrates that dysregulated redox homeostasis driven by elevated NOX4-derived ROS signaling underlies differentiation in the diseased prostatic stroma.
Collectively , we developed a useful platform to evaluate the human responses to dietary regimens low in calories.
Collectively , we elucidated core networks for DNA damage repair in SCA1 that might include the aberrant usage of HR.
Collectively , we suggest that cyclin K may be a novel molecular link between germ cell development , cancer development and embryonic stem cell maintenance.
Collective needs related mainly to housing , general organization of activities and nutrition.
College-educated and healthy encore adults-across age and gender divides-are more likely to exercise and watch less television.
Colles ' fractures ( fractures of the distal radius ) are extremely common in the elderly.
Colloid solutions were delivered by the closed-loop system for intravascular volume expansion using data from the Nexfin™ monitor.
Co-localization of Casp6 activity , PHF-1 and β-amyloid was detected mostly in the anterior olfactory nucleus ( AON ) of the olfactory bulb.
Colocalization of human P-tau and AChE supports the conclusion that P-tau can act to increase AChE.
Colocalization with glutamine synthetase revealed that the 4-HNE positive profiles in the inner nuclear layer were Müller cells.
Colon and breast cancer patients treated at prefectural designated regional cancer hospitals or clinics were younger than those treated at other types of facilities.
Colonic bioengineered rings from aged CSMC showed reduced force generation compared with colonic bioengineered rings from adult CSMC.
Colonic bioengineered rings from aged CSMC transfected with wt-cav-1 cDNA showed force generation similar to colonic bioengineered rings from adult rat CSMC.
Colonic CMV in inflamed mucosa was detected using quantitative real-time PCR.
Colonization with methicillin-resistant Staphylococcus aureus ( MRSA ) was associated with subsequent infection ( odds ratio , @number@ @percent@ confidence interval , @number@.2-154.2 ) .
Colonoscopy results showed reduced lesions and decreased areas with bleeding and edema in the sigmoid colon and rectum.
Colon to rectum ratio was 1 : 1 in males and 2 : 1 in females.
Colony forming capacity did not differ between young and old patients.
Color aspect was assessed by optical images after biodegradation whereas collagen cross-linking was investigated by micro-Raman spectroscopy.
Color change ( ΔE ) was measured at the start and end of conditioning.
Color change ( ΔE ) was measured at the start and end of conditioning.
Color differences ΔE ab and Δb among specimens were measured.
Color differences ΔE ab , Δb and Δa among specimens immersed in distil water and staining coffee beverages were evaluated overtime.
Colorectal cancer ( CRC ) is common among older adults and surgical resection with curative intent is the primary treatment of CRC.
Colorectal cancer ( CRC ) is one of the most common malignant diseases and frequent cause of cancer deaths in the world.
Colorectal cancer ( CRC ) is the most prevalent among digestive system cancers.
Colorectal cancer ( CRC ) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease.
Colorectal cancer is a leading cause of morbidity and mortality worldwide in both men and women.
Colorectal cancer is a significant worldwide health problem , and an altered immunoresponse plays an important role in colorectal tumorigenesis and cancer progression.
Colorectal cancer is one of the commonest tumours in the Westernized world affecting mainly the elderly.
Colorectal cancer screening tests should be discussed with all older adults because of the high incidence of colorectal cancer in this patient population.
Colorectal carcinoma is one of the most frequent tumor entities worldwide.
Color measurement was done using colorimeter based on the CIE L a b color scale.
Color stability and transmittance were evaluated after different periods of artificial aging , according to ISO 7491 : 2000.
Color values of each group were measured using a spectrophotometer after @number@ hours and @number@ weeks of aging in the aforementioned solutions.
Color varied in the sequence : DMAEMA < DEPT < DMPT < CEMA < DABE.
Color was assessed in the CIELAB using a colorimeter before and after each storage period.
Colour degradation limits the useful lifespan of maxillofacial silicones.
Colour of the maxillary central incisors was examined by VITA easy shade.
Colour preferences may change from childhood to adulthood and are significantly different in various age groups.
Coma was used to qualify only one oxazepam overdose.
Combat-related vascular injuries are present in @percent@ of this cohort , a rate @number@ times higher than in prior wars.
Combination adjuvantation systems may provide enhanced immune activation but have typically been developed without regard to the age of the target population.
Combination antiretroviral therapy ( ART ) has increased patient survival , which is currently similar to that of the general population in western countries.
Combination antiretroviral therapy ( cART ) has extended the longevity of human immunodeficiency virus ( HIV ) -infected individuals.
Combination antiretroviral therapy for HIV infection improves immune function and eliminates the risk of AIDS-related complications but does not restore full health.
Combination antiretroviral therapy was started with lamivudine , abacavir and lopinavir / ritonavir , with subsequent addition of efavirenz and enfuvirtide.
Combination antiviral therapy use and age were not significant predictors in this model.
Combination of F2RL3 methylation and pack-years predicted lung cancer incidence with high accuracy ( optimism-corrected Harrell's C statistics = @number@ for participants≥65 years ) .
Combination of KY17 with an autophagy inhibitor may be a valuable strategy for the chemoprevention or treatment of colon cancer.
Combination of subjective ( SHS ) and objective ( RTL ) measures is a novel tool for health aging investigation.
Combinations did not improve accuracy.
Combinations in pairs ( double arrays ) were assessed ( range : 0-3 ) .
Combinations of factors should be considered in risk stratification schemes to select appropriate implantable candidates.
Combination therapy can achieve greater BP reductions than monotherapy and can also enhance the safety and tolerability of pharmacotherapy.
Combination therapy has proven to be an effective strategy for treating many of the world's most intractable diseases.
Combination therapy is adopted in the real-world setting as first-line therapy on a not-infrequent basis.
Combination therapy is a safe and more effective strategy than IPL monotherapy for skin rejuvenation in Asian people.
Combination therapy is frequently required.
Combination therapy is superior to either modality used alone.
Combination therapy showed significantly greater improvements compared to monotherapy at two follow-up visits ( P < @number@ ) .
Combination therapy using two drugs with different , complementary mechanisms of action achieves better efficacy and tolerability outcomes than treatment with either component drug alone.
Combination therapy with LRR2 and LRR13 may effectively inhibit TLR4 activation.
Combination treatment may provide a slightly better cumulative benefit and also increase the persistence of effect.
Combination treatment produced longer-lasting results in dynamic forehead wrinkles , and greater static and dynamic wrinkle reduction in the glabella at week @number@
Combination treatment with PD0325901 and GSK-J4 further increased the rescue from embryonic lethality , ameliorating enlarged cardiac valves.
Combination trials of ibrutinib with venetoclax , a Bcl-2 inhibitor , are underway and are supported by sound preclinical rationale.
Combination with DXA is necessary , such as primary screening by QUS followed by secondary screening by DXA.
Combination with markers from non-physical dimensions does not improve its prognostic abilities.
Combined advances in modern medical practice and increased human longevity are driving an ever-expanding elderly population.
Combined aerobic and resistance training at a frequency of @number@ days / week improves CRF and muscle strength throughout the lifespan.
Combined analyses of these multiple levels of investigation revealed a complex cellular adaptive response to the protracted peroxide exposure.
Combined analyses show that letter , word , and motion processing impairments are independent of each other.
Combined analysis of B-K fusion and γH2AX expression can determine prognosis and may be a powerful tool to tailor therapy for these patients.
Combined approaches targeting both TECs and lymphoid cells will provide a potentially more effective strategy for sustained rejuvenation of the thymus.
Combined CA1-2 volume evidenced a negative linear association with age.
Combined differences in spine curvature and rib geometry led to an 18-mm difference in anterior placement of the sternum between young and old subjects.
Combined effects of dietary vitamin D and calcium were assessed based on high or low consumption of each nutrient.
Combined exercise protocols including endurance , strength and sensorimotor training showed larger improvements.
Combined measures of BMI + WHtR showed a stronger association with the outcome ( OR = 2.68 ; IC95% @number@ to @number@ ) .
Combined , our observations suggest that nickel and cobalt may exert their reproductive toxicity through perturbing @date@ activity in the stem cell compartment.
Combined , our study identifies Plk3 as a new and essential player in the regulation of the hypoxia signaling pathway.
Combined PAR was @percent@.
Combined RF and IPL treatment was more efficient than IPL alone in improving skin pigmentation , skin laxity , and texture.
Combined sarcopenia ( c-sarcopenia ) was defined as having either h- or w-sarcopenia.
Combined screening with FPG and HbA1c may identify older adults at very high risk for diabetes.
Combined significance of the pleiotropic effects was p = @number@.6×10-21.
Combined stage @number@ and @number@ meta-analyses showed significance for UMOD , GALNT11 , and CDH23.
Combined strength and endurance training or strength training alone did not produce significant changes in HR dynamics.
Combined symptoms of OAB and benign prostatic enlargement have recently gained increased research attention.
Combined therapy remains a potentially valuable approach to therapy.
Combined , there was a net loss of over @percent@ of beds.
Combined , these studies showed that nutrition exerts different effects on bone health.
Combined with extensive biological and other health measures , NSHAP enables researchers to address key questions on health and aging.
Combined with the aging of society in most developed countries , an ever-growing number of patients will require surrogate decision-makers.
Combined with the published data from the two preceding studies , the authors conducted a time-trend analysis of MS epidemiology over 1951-2009.
Combined with trophic factor receptor occupancy calculations , these data implicate VEGF-A and PEDF as key RPE-derived factors promoting preservation of retinal structure and function.
Combined with Wnt-1 siRNA , PEG-PEI-Ce6 nanoparticle mediated PDT inhibited cell growth and enhanced the cancer cell killing effect remarkably.
Combining age estimates from multiple indicators , specifically the pubic symphysis and one auricular surface method , was superior to individual methods.
Combining animal and human work links up the causal chain from etiological factors , brain and physical development , to phenotypes.
Combining cases and controls , we identified a total of @number@ different heterozygous GCH1 variants , all at low frequency.
Combining dietary components may modulate many processes involved in ageing.
Combining different biomarkers might enhance our ability to identify those patients most at risk of developing the disease , and better predict their conversion rates.
Combining genetic and MRI biomarkers may provide opportunities to design primary prevention clinical trials that target high-risk groups.
Combining GM and WM volumes , SVM analysis showed @percent@ accuracy to distinguish FTLD-tau and FTLD-TDP pathologies across variants.
Combining height- and weight-adjusted SMIs can be a feasible method to define sarcopenia.
Combining information from different structural measurements may also be useful.
Combining integration instructions with the warning also did not reduce younger adults ' forgetting relative to baseline conditions in Experiment @number@
Combining intensity data from large numbers of samples may increase the ability to accurately call the genotypes of rare variants.
Combining interventions may increase overall effectiveness.
Combining in vivo PET imaging of dopamine synthesis capacity , fMRI , and a sensitive measure of cognitive flexibility , we reveal three core findings.
Combining key elements of all three models may maximize outcomes.
Combining miRNAs improves sensitivity and specificity of biomarker performance , and adding ApoE genotype improves classification.
Combining multiexponential T2 relaxation ( MET2 ) and multishell diffusion MRI ( dMRI ) techniques may elucidate such processes.
Combining observations on adults with those for youth in the community indicated several phases of secular change in height that varied with years of birth.
Combining ' rejuvenation ' immunotherapy with standard chemotherapy may offer an improved outcome for elderly cancer patients.
Combining RT with a BAL protein distribution \ "rescued \ " the lower rates of myofibrillar protein synthesis during moderate ER.
Combining speeds , the OG generated @percent@ less A2 power and @percent@ less A2 work ( p < 0.05 ) .
Combining the direct and indirect effects , the total effects of childhood advantages on survival and health are positive.
Combining the model outcomes with intervention cost estimates , this study provides insight into the long-term cost-effectiveness of the intervention.
Combining the @number@ datasets yielded no association.
Combining the prenatal with a systemic infection during aging , we were able to enhance this pathophysiological effect significantly.
Combining these algorithms with the finite-element method ( FEM ) , the microstructure of vertebral bone has been predicted for up to @number@ simulated years.
Combining various approaches to elucidate these mechanisms could improve blood product quality and transfusion safety.
Comedication and cART registered in the database were listed.
Comfortable walking speed ( CWS ) is indicative of clinically relevant factors in the elderly , such as fall risk and mortality.
Comfort was rated by the patients , whereas safety and quality were determined by the endoscopists.
Commencing in @number@ the Medicare Access and CHIP Reauthorization Act ( MACRA ) of @number@ will change how Medicare pays health professionals.
Commercial fillers have a valuable place in the cosmetic surgeon's armamentarium and offer immediate volume correction with a more modest financial commitment.
Commercially available medical claims databases contain timely records of childhood vaccinations given in physician offices.
Commercially available microelectrode arrays ( MEAs ) were placed in a solution of hydrogen peroxide at @number@ °C for a period of @number@ days.
Commercial mechanisms have laid the foundation for disease mongering of LOH and also have resulted a considerable expansion of the indications for treatment.
Commercial wearables have struggled to provide accurate analytics and have been limited by non-clinically oriented gait outcomes.
Committee members of the ( DGI ) listed potential ' Choosing Wisely items'.
Common adverse events included rash , diarrhea , and liver dysfunction.
Common adverse events of statins include statin-related muscle toxicity , elevation of transaminases , diabetes , and possible association with cancer.
Common AEs were headache and mild injection site reactions.
Common atrophy across variants was found in temporoparietal regions that comprise the posterior default mode network ( DMN ) .
Common attributions include ageing ( @number@ @percent@ ) , medication ( @number@ @percent@ ) and personal stress ( @number@ @percent@ ) .
Common carotid artery plaque was defined as focal encroachment of the arterial wall and CCA calcification as acoustic shadowing.
Common causes are trauma , burn , surgery , vaccination , skin piercing , folliculitis , acne , and herpes zoster infection.
Common complications are comorbidities , polypharmacy , and adverse effects of drugs.
Common cost control mechanisms , e.g. curtailment of patient access and treatment prioritization , are likely to be adversely viewed by citizens.
Common environmental exposures , such as smoking , may play roles.
Common fragile site ( CFS ) loci are particularly sensitive to replication stress and undergo pathological rearrangements in tumors.
Common genes were found to contribute to both olfaction and cognition.
Common genetic variants with the potential to influence disease risk exist in both genes.
Common indications for the treatment of hyperkinetic lines with BTX are presented in this publication.
Common issues for caregivers included being woken at night , having problems getting back to sleep , trips to the bathroom , and daytime sleepiness.
Commonly applied models are selected on statistical rather than physiological considerations.
Commonly encouraged PA goals do not guarantee improved endothelial function and may not be as effective in reducing CV risk.
Commonly measured constructs of mobility included walking , climbing stairs , and lower extremity function.
Commonly used questionnaires were not sufficiently sensitive for the detection of high risk status for OSA in this patient population.
Common mechanisms such as chronic inflammation and immunosenescence , and common risk factors such as diabetes and obesity , have been implicated.
Common medications listed in the majority of these criteria are also summarized.
Common pathologies were coded from the lumbar spine MRIs from @number@ consecutive people imaged while attending a publicly-funded secondary care outpatient facility in Denmark.
Common pathophysiological alterations and biomarkers in the two syndromes have been recently described.
Common quantitative health outcomes included cognition , function , mood , and quality of life.
Common reasons for increases were more social occasions and fewer responsibilities.
Common scales for physical functioning are not directly comparable without harmonization techniques , complicating attempts to pool data across studies.
Common sense might suggest that TTA is the basis for pedestrians ' gap selection.
Common single nucleotide polymorphisms ( SNPs ) in pre / pri-miRNAs may change their property through altering miRNAs expression and / or maturation.
Common SNPs ( rs3480 and rs16835198 ) of the FNDC5 gene were genotyped with the TaqMan assay.
Common spending categories included \ "neurosciences , \ " \ "cancer , \ " \ "prevention , \ " and \ "aging. \ "
Common symptoms include intention tremor , ataxia , neuropathy , autonomic dysfunction , cognitive decline , and dementia.
Common symptoms include visual impairment which varies based on the type and the density of lens opacity.
Common variant genome-wide association studies ( GWASs ) have , to date , identified > 24 risk loci for Parkinson's disease ( PD ) .
Common variation defining the microtubule associated protein tau gene ( MAPT ) H1 haplotype strongly contributes to disease risk.
Communicable diseases , which were the leading causes of mortalities , are not anymore , especially in developed countries.
Communication about sexuality between health-care providers and older patients still implies a lot of barriers and lack of knowledge.
Communication and pain / symptom management were rated as the most critical domains.
Communication between neurons and microglia is essential for maintaining homeostasis in the central nervous system ( CNS ) during both physiological and inflammatory conditions.
Communication between them and helpers failed.
Communication difficulty was found to moderate the relationship between depression and pain.
Communication or assistive features were not used often.
Communication technology use was positively associated with formal and informal social participation for women and men.
Communication via mobile phones has become an essential tool for health professionals.
Communication within these networks is mediated by white matter tracts and is particularly prominent in the frontal lobes for the control and integration of information.
Communication with the patient , her family , other providers , and health care organizations is an important frontier in avoiding errors and adverse outcomes.
Communities that accommodate the needs of older adults in these domains will , it is thought , promote healthy , active aging.
Community-acquired pneumonia ( CAP ) is a common infectious disease in the United States and the incidence continues to grow as the aging population increases.
Community-acquired pneumonia ( CAP ) is an important cause of mortality and morbidity worldwide.
Community-acquired pneumonia ( CAP ) is one of the most common reasons for physician visits and hospitalizations in North America.
Community-acquired pneumonia ( CAP ) refers to pneumonia unrelated to hospitals or extended-care facilities.
Community-acquired pneumonia ( CAP ) remains a leading cause of morbidity and mortality among the infectious diseases.
Community-based autopsy studies show that frail individuals have brains that show multiple deficits without necessarily demonstrating cognitive impairment.
Community-based intervention may take considerations into specific types of activities to optimise cognition.
Community-based interventions that met in groups and used behavioral change strategies produced the largest effect sizes.
Community-based organizations ( CBOs ) serving persons living with HIV or AIDS face the challenge of an aging population with more chronic diseases.
Community-based preventive care programs specifically tailored to older adults are needed to address this challenge.
Community based resistance training is suitable for improving strength and reducing cardiovascular and metabolic risk factors in healthy older individuals.
Community-based service learning ( CBSL ) provides an opportunity to teach internal medicine residents the social context of aging and clinical concepts.
Community-based studies are important for this early identification because adults of this age are unlikely to present in clinics.
Community characteristics were derived from census data.
Community characteristics were not correlated with caregivers ' use of dental care.
Community-dwelling adults aged more than @number@ ( n = @number@ ) were recruited in New South Wales , Australia.
Community-dwelling older adults can perform MSL safely , correctly , and reliably , and GS safely and reliably.
Community-dwelling older adults ( n = @number@ ) from the Women's Health and Aging Studies I and II were included in this cross-sectional analysis.
Community-dwelling participants are encouraged to engage in more LPA and cognitive activity to increase brain fitness.
Community-dwelling population of older Chinese adults were interviewed from @number@ to @number@ ( n = @number@ ) .
Community dwelling pre-seniors have the highest prevalence rate of oral impacts.
Community-dwelling women aged 70-80 years were randomly recruited using the Electoral Roll for a 2-year protein intervention study in Western Australia.
Community facilities and services supporting elderly were found to be insufficient.
Community hospices ( Ning Yang Yuan ) have been established by the Li Ka Shing Foundation.
Community institutions can play an important role in the delivery and monitoring of health and social services for the elderly.
Community-onset PVL-associated disease is common in the UK and mainly causes skin and soft tissue infections that do not require admission to hospital.
Community participation was measured using the Keele Assessment of Participation.
Community-practising dietitians are instrumental in providing credible nutrition information to facilitate healthy eating in older Canadians.
Community providers can reliably administer a fall risk screening algorithm with training and coaching.
Community-run programs , as well as dieticians and pharmacists , were identified as important resources for accessing information related to T2DM.
Community screenings were well attended and received by providers and older adults.
Community service providers recorded approximately @number@ physician-initiated referrals over a @number@ year-period post-training , compared to few beforehand.
Community sites hosted training workshops and screening events.
Community social capital can play a compensatory role in maintaining the mental health of older people.
Community structure has also been revealed in human brain structural and functional networks in previous studies.
Community structure is a universal and significant feature of many complex networks in biology , society , and economics.
Community wayfinding becomes more challenging with age and decrements in functioning.
Comon symptoms include retention , overactive bladder , sfincted dissinergy and urinary tract infections.
Comorbid conditions , common among the elderly , can further reduce tolerance to therapy.
Co-morbid conditions such as atherosclerosis and infections coupled with advanced age are known to contribute to increased risk of cerebrovascular diseases.
Comorbid conditions were assessed by questionnaire.
Co-morbid conditions were independently classified by two geriatricians , who determined whether or not a condition represented a contraindication to use of these drugs.
Co-morbid depression is prevalent in patients with obstructive sleep apnea.
Comorbid general medical illness increased the likelihood of mental health service use by older whites and Latinos.
Co-morbidities and ASA grade were higher in the emergency group.
Comorbidities and complications during hospital stay were obtained from medical documentation.
Comorbidities and dependence in activities of daily living ( ADLs ) were associated with BMI ≥ 30kg.m2.
Comorbidities and frailty represent well-known problems during and after surgery in elderly patients.
Comorbidities and information on treatments were obtained.
Comorbidities and multidrug use should be taken into account any time the therapeutic regimen is under consideration.
Comorbidities and polypharmacy make the management of gout flares challenging in this population.
Comorbidities are very common in patients with late-onset asthma and need to be taken into account in the management of the disease.
Comorbidities had considerable effects on the development of postoperative ileus ( POI ) .
Comorbidities , physical performance , cognitive function , functional status , residual lifespan , depressive symptoms and experienced loneliness were measured during home visits.
Comorbidities require the use of other drugs , which increases the possibility of drug-drug interactions.
Comorbidities were also more prevalent in this cohort compared with rates of comorbidities in age-matched Australian men from the general population.
Comorbidities were determined by examining diagnosis codes.
Comorbidities were measured by a modified Elixhauser comorbidities index.
Co-morbidities were present in @percent@ of the patients , including neuropsychiatric illnesses in @percent@.
Comorbidities were related to inflammation in this sample , which could increase the likelihood of premature mortality.
Comorbidity and use of medication is often greater among people with than without diabetes.
Comorbidity encompassed many different combinations of chronic diseases.
Co-morbidity had little impact on prior analgesic use.
Co-morbidity increased concordance for all health conditions and decreased concordance for hypertension.
Comorbidity , low cognitive function , and residual lifespan as markers of health were not associated with life satisfaction.
Co-morbidity makes management of the elderly difficult also in terms of pharmacotherapy.
Comorbidity of alcohol / substance abuse was found to be @percent@ in patients with ICD whereas no cases were found in the group without ICD.
Comorbidity of NSD with hallucinations , agitation and apathy was higher in DLB than in AD.
Comorbidity prevalence increases over time , with discordant comorbidity increasing at the fastest rate among the oldest old.
Comorbidity scoring and geriatric assessment tools are helpful in achieving such multidimensional evaluation in a systematic manner.
Comorbidity was examined using a structured questionnaire.
Comorbid medical condition burden was lower using the @number@ Beers Criteria.
Comordidities for people with HIV have not previously been described from a representative population perspective.
Companies are marketing products that are labeled \ "for men. \ "
Companions were rated as more helpful by patients who preferred active involvement of family in medical decision-making.
Comparable data from published literature was identified , and the differences were analyzed qualitatively.
Comparable findings were found for all-cause mortality.
Comparable numbers were collected in western ( @number@ ) and coastal ( @number@ ) sites.
Comparable reliability in hippocampal activation was found in the full and the abbreviated paradigm.
Comparable results were found in the validation cohort.
Comparable results were observed for incident MMD.
Comparable results were obtained with human and monkey AChE.
Comparable structural changes were reported for the aging brain , which may point to accelerated aging of WM structure in obese subjects.
Comparable to the effects of BMI , a @number@ standard deviation change in well-being was associated with a @percent@ change in HbA1c.
Comparable with other studies , use was greater among women and increased with age.
Comparative analyses were made between groups as well as within groups over time.
Comparative analyses were performed to detect intergroup differences between clinico-audiometric findings and middle ear measures , viz. tympanograms and acoustic reflexes.
Comparative analysis of cytogerontological investigations and / or gerontological theories of Weismann , Carrel , Hayflick , and the paper author is carried out.
Comparative analysis of the dynamics of the disease has a significant adverse course and prognosis in children with addiction.
Comparative assessment of COX-2 expression in chronological aging and photoaging was not previously studied.
Comparative data from octogenarians are included.
Comparative DLs were also measured for increments of a single interval located within six-tone isochronous sequences with different tone rates.
Comparative epidemiology frequently compares human and animal populations.
Comparative examination of pathogenic mechanisms of smoke-induced lung disease can shed light on the homeostatic pathways critical to maintaining lung health.
Comparative experimentation by marrow elution of an OP animal model demonstrated \ "floating segments \ " as a possible outcome.
Comparatively , less is known about the characteristic features of cells that have aged in vivo.
Comparatively little is known about adult age changes regarding D1 receptors.
Comparative microarray-based gene expression profiling was conducted on these cells and compared to the transcriptomes of human fetal liver and adult liver progenitors.
Comparative neuroimaging can identify unique features of the human brain and teach us about human brain evolution.
Comparative Q-PCR was utilized to investigate target gene ( P66SHC , EP300 , HDAC1 ) expressions respectively in H2O2 treated groups and normal cell groups.
Comparative results suggest a shift in expression in favour of smLRP1 in tumour cells that warrant further evaluation.
Comparative sperm proteome analysis from the young fathers and aged fathers was performed to discover key proteins.
Comparative statistical analysis was performed.
Comparative studies of early and late-onset patients in most cases have reported no differing profiles of cognitive performance.
Comparative transcriptome analysis showed that CR had a stronger impact on global gene expression than RM.
Compared to acute myocardial infarction the total disease burden of dementia is @number@ times greater.
Compared to adults , children have a significantly lower incidence of major diseases such as thromboembolic disease.
Compared to ambient temperature when bottle aging , lower temperature benefited key aroma retention and expectantly extended the shelf life of young litchi wines.
Compared to a negative control , @number@ h pre-incubation with @number@ mg mL Brain network connectivity differs across individuals.
Compared to BoNT / A injection , MFR therapy showed gradual and long-term improvement in periorbital rejuvenation.
Compared to both groups of typical matches , the results indicated atypicalities of attention and inhibition in adults with WS.
Compared to Caucasian women , Latinas were significantly more likely to be caregivers and used computers less often.
Compared to control mice , aging mice have shorter glottic closure durations , whereas ALS-affected mice have shorter VF abduction phase durations.
Compared to controls , dTGM had a lower hyperglycemia induced by an intraperitoneal glucose administration.
Compared to controls , participants with T2DM had decreased CBF in the resting-state default mode , visual , and cerebellum networks.
Compared to controls , the aMCI group showed altered directed connectivity weights between DMN regions in the fronto-parietal , temporo-frontal , and temporo-parietal pathways.
Compared to control , the ILI reduced REM-AHI and NREM-AHI during the 4-year follow-up.
Compared to cortical homogenates , small molecular weight oligomeric species were lower and intermediate species were enriched in basal forebrain in ageing and Alzheimer's disease.
Compared to deciduous dental pulp MSCs , NS mRNA expression gradually decreased upon aging in umbilical cord stroma-derived MSCs as culture time increased.
Compared to dialysis , kidney transplantation appears to be the best treatment for chronic kidney failure , even for older aged patients.
Compared to FF , SD-triggered cardiac sympathetic activation is blunted in FL.
Compared to GFAP , AQP4 appeared predominantly at later stages of plaque formation , in older mice , and within the processes of astrocytes.
Compared to glargine , detemir achieved similar endothelial protection with lower weight gain and less hypoglycaemia.
Compared to HC , PwMS walk slower which increases their AP MoS.
Compared to healthy seniors , the serum level of TGFβ was significantly decreased in Alzheimer's disease patients ( p < @number@ ) .
Compared to low-risk , persons with high-risk APOL1 had higher odds of elevated ACR ( aOR @number@ @percent@ CI @number@.0-7.3 ) .
Compared to males , females have higher demyelination ( p = 0.0064 ) .
Compared to males , the age-adjusted hazard for females was @number@ ( @percent@ CI @number@ @date@ ) .
Compared to males , the OR ( 95%CI ) of females was @number@ ( @number@ - @number@ ) .
Compared to married drivers , those divorced ( @number@ @number@.43-1.53 ) and widowed ( @number@ @number@.45-1.63 ) had higher adjusted ORs.
Compared to men , women had thicker cortical regions but greater rates of cortical atrophy.
Compared to men , women live longer but experience greater morbidity as they age.
Compared to MS patients without seizures , patients with epilepsy have an earlier MS onset and a higher EDSS score after similar disease duration.
Compared to neuropathological diagnoses , clinical diagnosis had high sensitivity to AD and high specificity to dementia with Lewy body / Parkinson dementia.
Compared to next generation sequencing , this method is rapid , reproducible , and affordable.
Compared to Nold , IAF showed marked slowing in PDD and DLB and moderate slowing in ADD.
Compared to nondiabetics , D patients were older , had greater BMI , lower E' , more cardiovascular risk and greater DDF.
Compared to non-Hispanic Whites , African Americans evidenced less improvement in memory and reasoning performance after training.
Compared to normal myofibers , BNIP3 immunostaining in DEVILated myofibers was reduced , whilst MAP-LC3b was indifferent.
Compared to normal young adults , older adults showed a significant increase in letter-recognition contrast thresholds and a significant decrease in RGC + layer thickness.
Compared to @number@ the likelihood of having slightly undermet needs in @number@ significantly decreased by @percent@ among rural residents and @percent@ among urban residents.
Compared to OC , OFR showed significantly ( p < 0.05 ) slower gait speed , and worse step and stride regularity.
Compared to other nonvisual functions , the light sensitivity of steady-state pupil constriction appears to remain relatively intact and is not profoundly altered by age.
Compared to patients aged 65-84 years , those aged 85 + years were more likely to be hospitalized and have a longer ED stay.
Compared to patients , caregivers ' expectations of trial results were more realistic.
Compared to placebo , caffeine increased sleep latency , shortened total sleep duration and reduced sleep efficiency.
Compared to premenopausal women , ESR1 and the ratio of ESR1 to ESR2 were lower ( p≤0.05 ) in postmenopausal abdominal and femoral SAT.
Compared to the classical ' acute ' p53 binding profile , ' chronic ' p53 peaks were closely associated with CpG-islands.
Compared to the control group , APN and AdipoR1 expression in the retina was elevated in the T1DM group , but AdipoR2 expression remained unchanged.
Compared to the dementia group , the COPD group had lower scores and fairly stable levels on all subscales of the GHQ.
Compared to the EMILIA study , we recorded higher rates of newly-diagnosed cerebral metastasis and cerebral progression in patients with stable peripheral metastases.
Compared to the general population of Hungary EQ-5D values of the demented patients are lower in all age groups.
Compared to the physically untrained students and patients , the athletes have a significantly higher level of muscle tissue.
Compared to the placebo , EG significantly reduced the global photo-damage score.
Compared to the young adults , the older adults produced hypometric primary saccades and delayed gaze fixation to the first target.
Compared to the young , both the cue- and probe-locked activities were prolonged in the older groups.
Compared to those in Group @number@ only those in Group @number@ and @number@ had an increase mortality risk.
Compared to those with normal cognition , HAND cases had higher FGM MI ( P = @number@ ) at baseline.
Compared to those without chronic conditions , those with ≥ @number@ chronic conditions had a @number@ to @number@ times higher risk of developing disability.
Compared to WE and AC men , SA men had higher levels of body fat , IR , comorbidities and diabetes.
Compared to women without nocturia , women who had nocturia reported poorer sleep quality.
Compared to young adults , older adults displayed the greatest decline in performance efficiency for the whole-body task.
Compared to young adults , older adults exhibited a shorter recovery step length , greater trunk flexion angles and exhibited smaller peak knee flexion angles.
Compared to younger adults , older adults attend more to positive stimuli , a positivity effect.
Compared to younger controls , older adults exhibited more EFL at ventilations of @number@ @number@ @number@ and 80L / min.
Compared to younger HF patients , older HF patients had diminished proportions of Bacteroidetes and larger quantities of Proteobacteria.
Compared to younger patients , older patients are more susceptible to sepsis caused by respiratory infection.
Compared to young healthy volunteers , older inpatients had increased fibrin generation and decreased thrombin generation.
Compared with ≥26 mEq / L , lower serum bicarbonate was associated with functional limitation.
Compared with 4D-MSPECT , sex remained significantly associated with EF determined by QGS methods , independent of age and body weight.
Compared with AD dogs , AG ones showed a significant increase in salivary cortisol concentrations after the SST.
Compared with adults , children have elevated bone marker levels due to high skeletal growth velocity and rapid bone turnover.
Compared with age-matched controls , total CD4⁺ T-cell counts did not differ between treated younger and older HIV-infected patients.
Compared with baseline neurological status , the majority of patients ( @percent@ ) reported being neurologically \ "better \ " or \ "unchanged. \ "
Compared with Caucasians , African-Americans had higher BMI levels , while Hispanics had similar BMI levels , but lower rates of increase over time.
Compared with CON , both programs showed positive short- and long-term effects on moderate-intensity PA ( p = 0.034 ) .
Compared with control mice , animals lacking miR-188 showed a substantial reduction of age-associated bone loss and fat accumulation in bone marrow.
Compared with controls , aMCI patients showed reduced activity in the hippocampus bilaterally , retrosplenial cortex , and left dorsolateral prefrontal cortex.
Compared with drugs , exercise is available at low cost and relatively free of adverse effects.
Compared with EM , MA had more prolate temporal semi-Ps in all the three age groups ( p < @number@ ) .
Compared with foreign results greater number of Icelandic participants lived alone and caregiver's distress was slightly higher ( @percent@ vs. @percent@ ) .
Compared with healthy controls , PwMS demonstrated a longer time to stability and required a larger number of steps to reach stability.
Compared with healthy controls , significantly decreased global and local network efficiency in aMCI patients were found.
Compared with healthy-weight women , underweight and obese women were more likely to die before @number@ years of age.
Compared with HIV- veterans , AMI rates among HIV + veterans with similar CVDRF profiles were higher.
Compared with HIV- veterans with high CVDRF burden , AMI rates were still higher in HIV + veterans.
Compared with individuals with no VRF , individuals with @number@ VRF did not exhibit significantly different change in FA.
Compared with low-salt , high-salt diet increased P-MBG ( P = @number@ ) , mainly driven by results in men.
Compared with men , the age-adjusted hazard ratio ( HR ) for women was @number@ ( P = .002 ) .
Compared with men , women reported more negative affective experiences when they were with their spouses than when their spouses were not present.
Compared with Met homozygotes , Val homozygotes showed significantly inferior short-term memory ( STM ) performance ( P = @number@ ) .
Compared with miRNA expression between different muscle tissues , @number@ miRNAs were up-regulated and @number@ miRNAs were down-regulated in the muscle of postnatal stage.
Compared with NHW men , MA men had significantly higher prevalence of cognitive impairment and hypertension.
Compared with nondiabetic plaques , diabetic plaques had more inflammation and oxidative stress , along with a lesser SIRT6 expression and collagen content.
Compared with normotensive subjects , hypertensive subjects had higher carotid-femoral PWV and AIx , and showed significantly lowered PP amplification ratio with age.
Compared with [ ( @number@ ) C ] PiB , [ ( @number@ ) F ] THK-5117 retention was higher in the medial temporal cortex.
Compared with @number@ the odds of a patient undergoing thumb CMC arthrodesis or prosthetic arthroplasty slightly increased between @number@ and @number@
Compared with OA and non-OA , AKU cartilage demonstrates a very low turnover state and has low levels of extractable matrix proteins.
Compared with other available dopaminergic therapies , dopamine replacement with LD is associated with the greatest improvement in motor function.
Compared with other methods , PCA has its own study procedures and features.
Compared with other subject groups , SuperAgers showed a lower frequency of Alzheimer-type neurofibrillary tangles ( p < @number@ ) .
Compared with Parkinson disease ( PD ) , potential genetic risk factors for mild parkinsonian signs have been largely unexplored.
Compared with patients with an ICD , patients in the non-ICD group were older and more likely to be female and white.
Compared with placebo amitriptyline is effective in CDH.
Compared with polyphenols such as resveratrol , the synthetic STACs show greater potency , solubility , and target selectivity.
Compared with Principal Component Analysis and ISOMAP , LLDME provides the most compact and efficient representation of the age-related hippocampal shapes.
Compared with protein , these positive associations were @number@ times greater for FFM% and @number@ times greater for LEP.
Compared with published data , LTL in survivors was similar to that in healthy individuals aged @number@ years older.
Compared with sporadic-early , C9orf72 patients revealed an occipital cortical thinning.
Compared with the Alzheimer's disease and control groups , patients with bvFTD obtained significantly higher scores on all dimensions for both emotions.
Compared with the CAMCOG total score they had significantly lower discriminative accuracy.
Compared with the existing researches , it was found that the kidney-tonifying herbal medicines may exert anti-aging effects in multiple pathways in this study.
Compared with the extensive studies on anterolisthesis , limit data are available on the characteristics and clinical relevance of lumbar retrolisthesis.
Compared with the incident depression group , those with remitted depression were less likely to report having lost a job or experienced a major illness.
Compared with their young counterparts , aged rats required much higher doses to attain a similar level of anesthesia.
Compared with their younger counterparts , older patients had a greater burden of comorbid illness.
Compared with the low-stable group , trajectories with elevated BP levels had greater odds of having a CAC score of @number@ HU or greater.
Compared with the negative control group , the aging cells of the activated group appeared relatively late.
Compared with the normal elderly and mild Alzheimer's disease subjects , the MCI subjects were characterized by an intermediate power of posterior alpha1 sources.
Compared with the original model , the modified PF model was a better fit to the data and with improved predictive accuracy.
Compared with the PDFF , all T2 -weighted fat fractions significantly overestimated the fat fraction.
Compared with the placebo group , supplementation also resulted in significantly higher blood DHA levels ( p < @number@ ) .
Compared with the sedentary group at baseline , both the low and high activity groups were less likely to experience cognitive decline.
Compared with the treatment period , more than half of patients ( @percent@ ) answered that their present condition was better.
Compared with the western reference population , handgrip strength was lower due to a lower height and BMI but declined over age similarly.
Compared with the young adult and middle-aged groups , elderly adults demonstrated lower GLS , GRS , GCS , and GAT.
Compared with traditional health-care service models , healthcare needs of older people may differ extensively.
Compared with traditional methods , G-SMuRFS not only demonstrates a superior performance but also identifies a small set of surface markers that are biologically meaningful.
Compared with traditional moderate-intensity continuous exercise training , HIT confers equivalent if not indeed superior metabolic , cardiac , and systemic vascular adaptation.
Compared with veterans , fewer nonveterans reported any pain ( @percent@ ) or severe pain ( @percent@ ) .
Compared with White women , Hispanic women were @percent@ less likely to be insured ( p < @number@ ) .
Compared with wild-type mice , mice functionally deficient in all the p73 isoforms exhibit decreased ATG5 expression and lower levels of autophagy in multiple organs.
Compared with wild-type mice , Slc25a24-KO mice had significantly lower body weights and white adipose tissue weights.
Compared with wild-type mice , we detected FC deficits in both adult and old apoE4 and apoE-KO mice.
Compared with women born in @number@ the risk ratio for women born in @number@ was @number@ ( @percent@ confidence interval @number@ to @number@ ) .
Compared with women , men reported significantly worse hearing and found light touch less appealing.
Compared with YLA , YHA and MLA displayed attenuated vagal withdraw response ( HF ) to ST.
Compared with young adults , blood DHA is often slightly but significantly higher in older adults without any age-related cognitive decline.
Compared with young adults , older participants were impaired in the creation of cognitive maps and showed reduced theta and alpha activity at encoding.
Compared with young and old controls , @number@ and @number@ genes were up-regulated in osteoporosis , respectively , and @number@ genes were shared.
Compared with younger and midlife adults , older adults were motivated to volunteer by societal concern and esteem enhancement.
Compared with younger caregivers , older caregivers reported more fair or poor health and physical distress but more satisfaction with life and lower mental distress.
Compared with younger individuals , a larger absolute risk reduction is observed in the elderly because of the higher baseline fracture risk.
Compared with younger listeners , older listeners rated consonant chords as less pleasant and dissonant chords as more pleasant.
Compared with younger patients , older adults ( ≥ @number@ years ) had more VOM , prosthetic-joint infections and enterococcal OAI.
Compared with younger people , living with a partner more strongly predicted happiness in people in their 70s.
Compared with young patients , response to sepsis was altered in elders concerning EMP , annexin V MP , and TF-bearing MP.
Compared with young rats , aged rats showed significant increase in creatinine level with cellular senescence in the proximal convoluted tubules confirmed by beta-galactosidase staining.
Compared with young subjects , the elderly individuals exhibited a diminished capacity to identify odors.
Comparing all dizzy patients with the non-dizzy group , lower systolic blood pressure was also significantly associated with dizziness.
Comparing data between registries is difficult and requires taking into account periods of recruitment and diagnostic tools.
Comparing fits of linear and multiphase growth models , we found that 2-phase models demonstrated better fit than did single-phase models across all time metrics.
Comparing individual surgeons , no statistically significant difference was noted in IPSS and IIEF-15 functional outcome scores.
Comparing marginal adaptation to enamel and dentin within each group yielded only for G1 no significant differences.
Comparing multiple reconstruction algorithms we found that a high-resolution ordered-subsets maximization algorithm with spatially variant point-spread function resolution modeling provided the most accurate data.
Comparing NF to CKD there was a significant difference : p < @number@
Comparing subgroups with different shapes of learning curves showed a difference in the directed functional connectivity in those subgroups.
Comparing Taiwanese grandparents across different types of caregiving shows that the associations of grandparent caregiving with health vary by living arrangement and duration.
Comparing the amount of variability stabilizing and destabilizing task-important variables enabled us to identify the variable of primary importance for the task.
Comparing the cognitive impairment and dementia groups , synaptophysin and SV2 were reduced , whereas Braak stage , TDP-43 and hippocampal sclerosis frequency increased.
Comparing the individual peptides , the phasic alterations in their anabolic or catabolic roles in the regulation of energy balance may exhibit dissimilar time-patterns.
Comparing the proteomes of these cohorts , we quantified changes in muscle contractile myosins and energy metabolism allowing for a clear identification of cachexia patients.
Comparing the results between subgroups , we observed that the degree of hearing preservation was greater in younger adults than in older adults.
Comparing these groups , all the differences at the nighttime and daytime with and without glare were significant.
Comparing the two samples , mean age increased in @number@ years and the number of diagnosis by @number@
Comparing with in p53 knockdown NP cells , relative high p53 expression in normal control NP cells inhibited autophagy and the pentose phosphate pathway.
Comparing with resistant patients , @number@ miRNAs were significantly upregulated and @number@ miRNAs were greatly downregulated in sensitive group.
Comparing younger / older subjects , progression-free survival was significantly higher in the younger group ( P < .0001 ) .
Comparison between groups revealed greater activation of the right inferior occipital gyrus in young participants than in elderly participants for HSF.
Comparison between males and females , and comparison between both hemispheres among all participants were also performed.
Comparison between mean SUV in four visible arterial segments between the two genders did not reveal any statistically significant difference.
Comparison between same speeds in walking and running revealed that in contrast to young no additional hip loading is imposed during running in elderly.
Comparison of chronically endurance-trained older adults vs S revealed differences in MitoVd , ATPmax , and some electron transport chain protein complexes.
Comparison of Groups @number@ and @number@ revealed no difference in radiological OA in the lumbar region and knee joint.
Comparison of results from different surveys should always be performed with caution , taking into consideration the way of grouping of paediatric patients.
Comparison of selected indicators of stability between the groups of the women was made with the Mann-Whitney U test.
Comparison of subjective with objective childhood neighborhood measures found moderate associations in hypothesized directions.
Comparison of the Austrian and Ukrainian models indicated that the former markedly overestimated fracture probability whilst correctly stratifying risk.
Comparison of the differences in the mean score index of EQ-5D between baseline and after @number@ months also showed no statistically significant differences.
Comparison of the efficacy of different forms of BoNT-A must be made with the full understanding that the dosing units are not equivalent.
Comparison of the exposed to unexposed arm site showed difference only for the lipid compactness at the older group studied.
Comparison of the recruitment speed allows establishing an order of DNA repair events.
Comparison of these findings to mutations in hematological malignancies identified several recurrently mutated genes that may be disease initiators.
Comparison of these properties help to understand the relationship between healthy ageing , and age-dependent joint degeneration and osteoarthritis.
Comparison of those contacted who agreed versus declined to participate revealed a greater proportion of males who declined participation ( P = @number@ ) .
Comparison of those retired early with and without disability showed a significantly higher frequency of lower educational attainment both personally and for parents.
Comparisons among age and sex groups were analyzed using the Mann-Whitney test.
Comparisons amongst use groups ( i.e. , current- , future- , and non-alcohol using adolescents ) identified rCBF associated with initiation of alcohol use.
Comparisons between 16-17 , 18-21 , and 22-25 year olds are highlighted.
Comparisons between age groups , genders , and aspiration status were made.
Comparisons between baseline standing height and knee-derived height were done with simple correlations , limits of agreement ( Bland-Altman plot ) and Deming regressions.
Comparisons between drivers and ex-drivers were calculated using chi ( @number@ ) and Student t-tests as appropriate.
Comparisons between groups of slower and faster individuals were made with regard to executive functions and physical fitness parameters.
Comparisons between layers showed a higher deterioration rate with aging in the anterior layer than in other layers.
Comparisons between the individuals deceased , interviewed and those who dropped out yielded significant differences mainly due to contextual variables.
Comparisons between their 5- and 10-year reports were performed using paired t-tests for numeric variables and McNemar's test for categorical variables.
Comparisons of levels of neuroinflammation and neurogenesis between TBI alone and TBI + PTSD revealed that PTSD did not exacerbate the neuropathological hallmarks of TBI.
Comparisons of methylation profiles among species reveal evolutionary conservation of gene body methylation patterns , pointing to the fundamental role of epigenomes in gene regulation.
Comparisons of sRAGE and AGEs levels between groups were assessed by t-test.
Comparisons of the 5-year age-related and treatment-related EF decline show that @percent@ of the long-term EF decline is related to aging.
Comparisons of the adjusted mean scores on the EQ-5D index between normal and abnormal SPPB groups were performed.
Comparisons of these utilization measures contribute to knowledge of the relative tolerability of these medications.
Comparisons of the times to first , second and third crises between the senicapoc and placebo groups were not statistically significant.
Comparisons on the basis of gender were performed using analyses of covariance with age as covariate.
Comparisons using survey-weighted χ2 tests and logistic regression were made.
Comparisons were determined by both physician assessment and subject self-assessment at baseline , @number@ @number@ and @number@ weeks.
Comparisons were made between the tau P301L mice and control mice , as well as between different age groups.
Comparisons were made by ANOVA.
Comparisons were made nationally and within regions and health plans , and changes since @number@ were assessed.
Comparisons were made to @number@ HIV-uninfected individuals from a population-based sample.
Comparisons were made with @number@ age- and education-matched younger and @number@ matched older healthy seronegative males.
Comparisons were performed by factorial analysis of variance.
Comparisons were performed by factorial analysis of variance.
Comparisons were then made between age groups and between positions.
Comparisons with chimpanzees , our closest living primate relative , are critical in this endeavor.
Comparisons within groups showed stability over @number@ year.
Comparison was conducted based on hemorrhage location.
Comparison with a mouse heart proteome revealed conservation at the level of molecular function , biological processes and cellular components.
Comparison with countries providing universal coverage may illustrate whether the ACA can improve health outcomes and reduce disparities.
COMPARISON WITH EXISTING METHODS : The automatic LGN segmentation is objective , efficient , valid and applicable.
COMPARISON WITH EXISTING METHODS : This new device minimizes puff variations that exist with earlier smoke delivery apparatuses which could introduce confounding factors.
COMPARISON WITH EXISTING METHODS : We compared our results to four open-access IF-based cell-counting tools available in the literature.
Comparison with non-face stimuli showed that this decline was face specific , and did not concern processing of object features in general.
Comparison with other structural homologues revealed that the PB1 domain of BEM1P , ubiquitin-like domain of BAG6 and ubiquitin are structurally similar proteins.
Comparison with visual rating scales showed high significant correlations ( ARWMC : r = .86 ; CHIPS : r = .87 ) .
Comparitive analyses also revealed that , among FS groups , the frail subgroup performed significantly poorer on all PFF measures except body composition.
Compartmental models and Logan graphical methods enabled estimation of the total volume of distribution ( VT ) in regions of interest ( ROIs ) .
Compartment shrinkage and clonal expansions are challenges for naive CD8 T cells.
Compartment-specific age-effects in this cohort were evident as well.
Compassionate release derives from the theory that changes in health status may affect these principles and thus alter justification for incarceration and sentence completion.
\ "Compassionate release \ " describes a range of policies offering early release or parole to incarcerated patients with serious or debilitating illnesses.
Compassionate release is a program that allows some eligible , seriously ill prisoners to die outside of prison before sentence completion.
Compelling evidence has shown , that neurotrophins responsible for the regulation of neuronal growth , survival , and differentiation are involved in neurodegenerative diseases.
Compelling evidence implicates that in addition to inherited factors , acquired co-morbidities contribute to PD pathology.
Compelling evidence in the human indicates these neurons function in the hypothalamic circuitry regulating estrogen negative feedback on gonadotropin-releasing hormone ( GnRH ) secretion.
Compelling evidence points toward an interplay between circadian rhythms and cellular redox metabolism.
Compelling evidence suggests that improving nutrition protects health , prevents disability , boosts economic productivity and saves lives.
Compelling evidence suggests that soluble amyloid-β peptide ( Aβ ) oligomers induce synaptic loss in AD.
Compelling studies have supported the hypothesis that TBI accelerates the formation and accumulation of Aβ.
Compensated hypogonadism was more common in the EMAS cohort ( @number@ vs. @percent@ ; P < @number@ ) .
Compensation estimates were derived by multiplying lost work hours from presenteeism and absenteeism by wage / fringe.
Compensatory bioenergetic adaptations , or lack thereof , to estrogen loss could determine risk of late-onset Alzheimer's disease.
Compensatory oculomotor therapy has been found to be effective in improving the associated functional impairments in reading and visual exploration.
Compensatory saccade metrics may provide insights into capturing the impact of vestibular loss on physical function in older adults.
Compensatory strategy use increased in the MCI group and decreased in the dementia group.
Competing indirect links were assessed using the product-of-coefficients ( α β ) approach with bias-corrected bootstrap confidence intervals.
Competing norms and daughters-in-law also play important roles in the negotiation for parental help.
Competing risk regression models determined the rate of cardiovascular mortality , adjusting for similar confounders and using the total sample only.
Competing risk survival analysis was conducted to explore the association between risk factors and CVD mortality.
Complementary analyses using statistical parametric mapping ( SPM2 ) supported the findings of the visual analysis.
Complementary and alternative methods for VMS also showed limited but promising results , although more definitive studies are warranted.
Complementary or psychological therapies may be beneficial for those patients who have failed other options or have depression associated with chronic pain.
Complementation of Δron8 parasites restores invasion and reveals a processing event at the RON8 C-terminus.
Complement inhibition by C1-inhibitor preserved Klotho expression in vivo by abrogating nuclear factor kappa B ( NF-kB ) signaling.
Complement inhibition has been identified as a key candidate for therapeutic intervention , and drugs targeting the complement pathway are currently in clinical trials.
Complement is the backbone of our innate immune system.
Complement receptor @number@ ( CR1 ) has been considered to play an important role in late-onset Alzheimer's disease ( LOAD ) pathogenesis.
Complete blood counts were determined by Sysmex XE-2100 analyzer.
Complete clearance rates were @percent@ , @percent@ , and @percent@ respectively ( both P < .001 versus vehicle ) .
Complete clinical , therapeutic , and hematochemical data were retrieved.
Completed analysis was carried out on the @number@ ribs for which all the variables could be collected.
Complete data for @number@ people were available for analysis.
Complete data sets were obtained in eight subjects.
Completed measures include their perception of family support , emotional experience with dyslexia , self-esteem , and demographic variables.
Complete femoral neck images were scanned , and cortical bone boundaries were defined using our previously established method.
Complete healing of the lesions was achieved.
Complete hyalinization of intercapillary pillars was seen in the 10th decade.
Complete mediation was found between a CR composite and FA via an internally consistent D-KEFS composite score ( Cronbach's α = @number@ ) .
Complete nutrient intake assessments ( calorie counts ) were performed daily.
Complete obliteration was achieved in @number@ % by microsurgery , @number@ % by embolization alone and @number@ % by SRS.
Complete ontogeny data for each enzyme are needed to support in vitro to in vivo extrapolation ( IVIVE ) .
Complete records were available for @number@ ( @percent@ ) .
Complete resection of the residual tumors in the mediastinum and right lung was performed.
Completers showed gains in narrow walk time , self-reported balance confidence and mental health.
Completers were healthier than noncompleters.
Complete survival data at age @number@ were obtained from the Swedish Cause of Death Register.
Completing an internal medicine requirement using a geriatrics clerkship is an innovation for medical school curriculum structure.
Completing the web-based decision aid reduced mean Decisional Conflict scores from @number@ to @number@ ( p < @number@ ) .
Completion by several untrained nursing personnel confirms its utility in the nursing admission assessment.
Completion rates for participants aged > or = @number@ were higher than for younger participants.
Completion surgery may be indicated after endoscopic excision of these potentially metastasizing early cancers.
Complex age-related changes and sensitivity to drug toxicity can render diagnosis and treatment for elderly patients challenging.
Complex cognitive abilities such as planning are known to critically rely on activity of bilateral mid-dorsolateral prefrontal cortex ( mid-dlPFC ) .
Complex disease and age-related social factors are contributors.
Complex diseases are major contributors to human mortality in old age.
Complex etiologies are associated with development of SO.
Complex extracapsular fractures have become more common since @number@ which may explain the increased use of cephalomedullary nails.
Complex fluctuations within physiological signals can be used to evaluate the health of the human body.
Complex frequency ratios , on the other hand , evoke feelings of tension or \ "dissonance \ ".
Complex heterogeneity of obesity revealed that a tissue of an extreme plasticity and rich interactions with vital functions of the body lies under the surface.
Complex I + III activity was reduced by almost @percent@ , whereas complex IV , α-KGDH , and PDH activities were unaffected.
Complex interactions between hyperglycemia , glycemic variability and brain aging remain unresolved.
Complex interactions of genetic alterations , sex hormone deficit , and aging with mechanical factors and systemic inflammation-associated metabolic syndrome lead to joint damage.
Complex issues of multi-morbidity occur within aging populations.
Complexity analysis in addition to standard metrics may provide additional insight.
Complexity index ( CI ) is defined as the summation of entropies with coarse-graining scales 1-20 by MSE.
Complexity is a new measure for identifying the adaptability of a complex system to meet possible challenges.
Complexity of heartbeat interval series is typically measured by entropy.
Complexity of the revealed symptoms testified to an early organism aging in remote periods after exposure to low dose radiation.
Complexity scores increased as a function of age in controls , while SCH patients exhibited a progressive reduction of LZC values.
Complex I was the most upregulated complex and not stoichiometrically associated to the other complexes.
Complex mental activity induces improvements in cognition , brain function , and structure in animals and young adults.
Complex plaque was defined as either mobile or an ulcer-like pouch in the DTA.
Complex processes involving gene expression and epigenetic regulation are considered to perpetuate across generations.
Complex processes that occur in the developing brain with disease can be evaluated accurately only against normal aging processes.
Complex structural and functional changes occur in the arterial system with advancing age.
Complex therapeutic procedures like haematopoietic stem cell transplantation , cardiovascular surgery and solid organ transplantation are options for an increasing proportion of older patients nowadays.
Complex traits in mouse strains have been shown to have higher heritability and genetic loci often have stronger effects on the trait compared to humans.
Compliance for a cohort of home-based auditory therapy trainees was less than @percent@.
Compliance may modify these results and future larger sample studies should evaluate the impact of core stability training on STS biomechanics.
Compliance to treatment is an important issue in old age.
Compliance was good , as confirmed by erythrocyte membrane phospholipid FA concentrations , with significant increase of EPA and DHA in the intervention group.
Compliance was @number@ %.
Compliance with BP telemonitoring among patients was favorable , but compliance among participating healthcare providers was not well documented.
Compliance with the intervention was high , with children consuming on average @number@ of the @number@ sachets given.
Compliance with treatment should be monitored , and the treatment period should be individualized for each patient.
Complicated grief : A guidebook for therapists [ Liberty Version ] .
Complicated HZ was diagnosed in @percent@ of cases ; a relevant part ( @percent@ ) of hospitalizations involved subjects with at least one co-morbidity.
Complicated protocols that increase participant burden , overly restrictive entry criteria , the fear of an SLE flare may also affect enrollment in SLE trials.
Complicated skin and soft tissue infections constitute a heterogeneous group of severe disorders , with surgical site infections being the most common hospital-acquired ones.
Complication included gastroparesis in @number@ patients and pancreatic fistula in @number@ patients , and all recovered by conservative treatment.
Complication is rare with lid malposition , scaring , and temporary nerve function impairment being the most common.
Complication rates between patients with and without IS were compared.
Complication rates were low.
Complications , along with their prevention and treatment , are reviewed.
Complications , although not common , can be treated effectively and excellent outcomes achieved.
Complications and revisions were compiled , and a Kaplan-Meier survival analysis was performed.
Complications and therapies were identified by their respective codes.
Complications are mentioned , and the article concludes with a review of nonsurgical adjuncts.
Complications associated with diabetes can be prevented by early diagnostics.
Complications can be classified as immediate , early , or delayed onset ; available treatment options are presented.
Complications from VT and pulmonary embolism are the leading cause of lost disability-adjusted life years.
Complications included a slight burning sensation and mild erythema that were minor and transitory ; both resolved within @number@ hours.
Complications included some degree of bruising , erythema , and local swelling.
Complications include pain , erythema , bruising , and potential infection.
Complications occurred in @percent@ of patients.
Complications occurred mainly as a result of emergency procedures during emergency procedures and in major surgeries such as cystectomy and nephrectomy.
Complications of treatment included acute renal failure , cardio / respiratory failure , disseminated infection , and death ( @number@ case ) .
Complications related to hospital stay appeared in @number@ % of patients.
Complications related to such fillers are well known , especially in the case of hyaluronic acid , where overcorrection is the most frequent.
Complications such as gastroparesis and pancreatic fistula should be paid more attention.
Complications were documented in @percent@ of cases where sedation was used.
Complications were identified in @number@ patients who were treated with @number@ RDPs ( @number@ upper , @number@ lower ) .
Complications were roughly classified as nodular masses , inflammation , tissue necrosis and dyspigmentation.
Component processes do not fully account for the unique relationships between motor sequencing and EF in older adults.
Components included greater choice and availability of beverages , increased staff awareness , and increased staff assistance with drinking and toileting.
Components of anti-ageing and autophagy include SirTs and FoxOs.
Components of both the innate and adaptive immune system are implicated in the pathophysiology of the articular and extra-articular manifestations of the disease.
Components of the dopaminergic system may represent good candidates for longevity studies.
Composite agarose / polyacrylamide gel electrophoresis revealed that both these chains mainly form dimers of trimers , although Col28a1b appears to be more polydisperse.
Composite buildups were constructed incrementally with Tetric Ceram resin composite.
Composite events of in-hospital death and central nervous system disorders were significantly higher in the 2000s compared with the 1990s.
Composite facial images created from women who looked young or old for their age indicated that the structure of subcutaneous tissue was partly responsible.
Composite PQIs were able to differentiate LHAs and health districts and showed small variation in the performance ranking over years.
Composite resin rods were cemented to the zirconia plates with @number@ different cements.
Composite restorations degrade during wear , but it is unknown how wear affects the composite surface and influences composite-to-composite bonding in minimally invasive repair.
Composite Z scores of memory , processing speed , and executive function were derived from a battery of neurocognitive tests.
Compositional level measures of collective social functioning are important associates of food insecurity among older adults and seniors , regardless of severity.
Composition of majority of main meals and small amount of lunches and afternoon snacks was rational.
Compound 5c was discovered and shown to significantly inhibit the promoter activity of hTERT gene.
Compound ATX-101 is a proprietary formulation of purified synthetic deoxycholic acid for pharmacological submental contouring.
Compounding of marketed products has been recognized as being responsible for an increased number of adverse events and medical errors.
Compound K ( CK ) , one of the major metabolites of ginsenosides , mediates the antimetastatic and anti-allergic activities of the ginsenosides.
Compound mutations can worsen the phenotype.
Compound @number@ also reduced SA-β-gal activity in HUVECs under replicative senescence.
Compounds 2b , 3e , 7b and 12e were shown to selectively inhibit 11β-HSD1 over 11β-HSD2 , 17β-HSD1 and 17β-HSD2.
Compounds altered by MRJPs were mapped to nicotinate and nicotinamide metabolism , cysteine taurine metabolism , and energy metabolism pathways.
Compounds consisting of two or more amino acids , or peptides , are the building blocks of proteins.
Compounds derived from natural sources have gained considerable attention for use in sunscreen products and have bolstered the market trend toward natural cosmetics.
Compounds that interfere with proteases regulating Abeta formation from amyloid precursor protein ( APP ) are also actively pursued.
Compounds with the highest scores include lithium , minocycline , exenatide , valproic acid , methylene blue , and nicotine.
Comprehensive analysis of the GNAS and STX16 loci was undertaken to investigate the molecular defects underlying ( P ) PHP.
Comprehensive assessments should include a detailed investigation of a patient's pain and medical history , a physical examination , and diagnostic testing , if needed.
Comprehensive clinical assessment in combination with evaluation of language , socio-emotional functioning , cognition and neuroimaging aid in accurate and early diagnosis and treatment planning.
Comprehensive clinical assessments of dementia severity were systematically carried out at ∼18 month intervals.
Comprehensive diagnostic and detection techniques for an underactive detrusor are necessary.
Comprehensive efforts will need to be directed towards early diagnosis , as well as developing safe and effective treatment.
Comprehensive evaluation of brain scans concomitantly with blood micronutrient examinations may provide reliable criteria for the estimation of the optimal micronutrient intakes or blood concentrations.
Comprehensive evaluations were conducted at @number@ @number@ @number@ and @number@ months after enrollment into the registry.
Comprehensive geriatric assessment allows a detailed evaluation of the state of health of a specific subject and can modify the therapeutic decision.
Comprehensive geriatric assessment appeared an important trigger for referral and treatment in our participants.
Comprehensive geriatric assessment , cognitive and mood assessment , QOL scales ( IIQ-7 , UDI-6 ) were performed.
Comprehensive geriatric assessment might help to optimize care of CRC patients , by improving early identification and management of comorbidities and geriatric syndromes.
Comprehensive geriatric evaluation was performed.
Comprehensive history taking , anthropometric measurement , laboratory testing , and questionnaire administration were performed for each of the total @number@ women enrolled.
Comprehensive metabolomics approach was applied to analyze baseline serum samples and to associate the metabolite profiles with the diagnosis at baseline and in the follow-up.
Comprehensive , multidisciplinary assessment of elderly patients is imperative in evaluating eligibility for beneficial therapies.
Comprehensive neuropsychological testing assessed memory , executive function , and psychomotor speed.
Comprehensive psychopathological ( depression and tinnitus-related distress scores ) and psychometric data ( including other tinnitus characteristics ) were gathered.
Compression and shear with wetness produced the highest skin surface loads.
Compression of cervical nerve roots may result from disc degeneration , disc herniation or intervertebral foraminal stenosis.
Compression testing was undertaken to evaluate cement strength over time during immersion in water.
Compressive dressings were maintained for @number@ days.
Compressive strength ( CS ) and Streptococcus mutans viability were used to evaluate the mechanical strength and antibacterial activity of the cements.
Comprising @number@ common neuropsychological tests ( @number@ measures ) , the battery assesses cognitive domains affected early in the course of Alzheimer disease.
Compromised cellular energy metabolism , cerebral hypoperfusion , and neuronal calcium dysregulation are involved in the pathological process of Alzheimer's disease ( AD ) .
Compr Physiol 7 : 1009-1049 , @number@
Computational analysis suggested that @number@ anthocyanins from chokeberry fruit increased Klotho ( aging-suppressor ) structural stability , so we hypothesized that chokeberry anthocyanins could antiaging.
Computational approaches estimate leukocyte composition from DNA methylation based on reference datasets of purified leukocytes.
Computational biology and computational medicine are no longer intellectual domains of the chosen few.
Computational modeling suggested that this was attributable to older adults ' persistent reliance on suboptimal , unidimensional strategies when 2-dimensional strategies were optimal.
Computed tomographic scans were performed after injection of a radiographic contrast medium directly into the fat compartments surrounding prominent facial folds.
Computed tomography ( CT ) of the chest revealed a nodule in the left lower lobe of the lung.
Computed tomography data were collected between ages @number@ and @number@
Computed tomography scans were collected to define the radiological density of the vertebral bodies and to calculate Young's modulus.
Computed tomography was used to determine postoperative fusion status.
Computer-aided design and computer-aided manufacturing zirconia copings were fabricated.
Computer-assisted evaluation of vascular areas was performed.
Computer classes for older adults make significant contributions to social and cognitive aspects of aging.
Computer exercise selection and difficulty level parameters optimized adherence.
Computer experience , user involvement , and nursing management support were found to significantly explain information system use.
Computer-generated allocation was done in blocks of four ( two individuals randomly allocated to each group ) at each site.
Computerized Cognitive Training ( CCT ) is a promising strategy to combat cognitive decline.
Computerized drill and practice exercises were used with bridging to activities of daily life.
Computerized records were queried for the administration of the above medication classes in two academic EDs over two similar 4-month periods in @number@ and @number@
Computerized tomographic ( CT ) images of @number@ cranial samples were available.
Computerized tomography and magnetic resonance imaging are the more appropriate methods to diagnose pancreatic hyperechogenicity when compared with transcutaneous or endoscopic ultrasound examination.
Computerized tomography examinations for CAC were obtained locally and analyzed by a central reading center in blinded fashion.
Computer modeling provides improved methods to assess volumetric changes to augment and restore the facial volume.
Computer morphometry of leukocytes of peripheral blood was made to all patients.
Computer science , engineering , and medical databases were extensively searched and the retrieved items were systematically reviewed.
Computer simulations and experiments using in vivo very preterm data showed very high detection accuracy.
Concealed CKD contributes to profile the elderly patient at greater risk of death after being discharged from acute care medical wards.
Conceivably , no other species or experimental model will ever develop the full spectrum of AD-typical alterations.
Conceivably , this epigenetic regulation contributes to the age- and / or population specific effects reported for MCHR1 in several human obesity studies.
Concentrating on personal health and well-being has become a central objective for people living in wealthy societies.
Concentration-dependent relations were determined from experimental human data or estimated from animal studies , with the impact of all assumptions explored via parameter studies.
Concentration of endogenous dipeptide carnosine in human muscle tissue reaches tens of millimoles.
Concentrations changed with age , suggesting age-related changes in phthalate exposure and perhaps metabolism.
Concentrations of 5-MTHF and total homocysteine ( tHcy ) ( r = @number@ ) and S-adenosylmethionine ( r = @number@ ) were correlated at baseline.
Concentrations of fibrinogen and glucose are not affected by the dance therapy in older women , suggesting maintenance of homeostasis.
Concentrations of free testosterone , dihydrotestosterone , and estradiol mirrored that of total testosterone.
Concentrations of GOT were significantly higher in males than in females ( P < @number@ ) .
Concentrations of GPT were significantly higher in males than in females ( P < @number@ ) .
Concentrations of lipids in blood were always highest in the older adults.
Concentrations of @number@ non-cholesterol HDL particle components and @number@ HDL-cholesterol ( HDL-C ) particle size subfractions were determined.
Concentrations of serum creatine kinase , lactate dehydrogenase , myoglobin , high sensitivity c-reactive protein , and TNF-α were measured.
Concentrations of this peptide are increased in subjects with hypertension , primary pulmonary hypertension and myocardial infarction , however its short half-life makes quantification difficult.
Concentrations of TSH and thyroxine were measured.
Concentrations of unmetabolized FA were positively related to those of 5-MTHF and THF.
Concentrations of ΣDEHP metabolites decreased over the study period ; however , concentrations of DiNP metabolites increased.
Concentrations were compared after age stratification and were matched with patient and dialysis characteristics.
Conceptions of adulthood have changed dramatically in recent decades.
Concepts and relationships derived from Roy's model of adaptation are included.
Concepts in AGS Beers and STOPP can be incorporated into polypharmacy reduction strategies to improve outcomes of care for older adults.
Concepts of health and homeostasis are discussed and their connection to longevity is analyzed.
Conceptualize and evaluate their life quality is a challenge , being hard to characterize the impact on daily activities and on functional capacity.
Conceptually disentangling the initial age-related vulnerabilities from changes that result in adaptive response will be a major challenge for the future research on brain aging.
Conceptually , inflammation-responsive RBPs represent an attractive target of rational therapies to combat vascular inflammatory syndromes.
Conceptually sound , objective , precise measurements are needed to advance knowledge of disc degeneration and its causes , progression , and consequences.
Conceptually the salutogenic model focuses on the direction towards the healthy end of the health continuum.
Conceptual models of gait may facilitate a reasoned approach to outcome selection.
Conceptual novel approaches entering the clinics to treat cardiac remodeling and heart failure remain scarce.
Concern about adverse effects of traditional hormone therapy often leads women to purchase over-the-counter ( OTC ) natural health products ( NHPs ) .
Concern for this group is crucial , given its health disparities and the association of IDU with disease transmission.
Concerning assistive ICTs , they manifested a lack of perceived need and usefulness.
Concerning B lymphocyte subsets , experimental data obtained in the mouse model and in vivo studies conducted in old-age humans are frequently controversial.
Concerning cART , daclatasvir / sofosbuvir is the most favorable combination as no cART is contraindicated with this combination.
Concerning cholinesterases , LP was the most active , mainly due to lemon juice contribution.
Concerning cobalamin therapy , @number@ patients ( @number@ % ) received oral therapy and @number@ ( @number@ % ) intramuscular therapy.
Concerning cognitive effects , left-right performance was most strongly related to attentional abilities , while front-back performance showed a relation to working memory abilities.
Concerning ellagitannin composition , the barrel toasting effect seemed to be more important than differences due to MLF container.
Concerning masticatory function , missing teeth along with oral disease seem to accelerate the dysfunction.
Concerning outcomes , in the OC-1 group only mobilization time was significantly lower ( p = 0.01 ) .
Concerning red areas , the experimental group had better results on weeks @number@ @number@ and @number@ ( p < @number@ ) .
Concerning SIRT1 , no association between the SNPs under study and longevity was observed in the only available report.
Concerning the design of clinical trials , a possible strategy is to enrol elderly patients without upper age limit and to plan stratification.
Concerning these steps we are still on the level of recommendations for preserving our general health and data of relevant science are quite contradictory.
Concerning the speed of the cerebral aging process , significant inter-individual differences can be observed.
Concerns about everyday memory difficulties , and anxiety and depression scores were strong predictors of poorer quality of life.
Concerns about the impact of healthcare reform on quality and healthcare costs differed significantly.
Concerns focused primarily on inability to recall staff and resident names and activities , schedules , and appointments.
Concerns have been raised about the risk of hemorrhage in patients having received warfarin.
Concerns raised with this preventive measure include safety and efficacy issues as well as the financial implications.
Concerns regarding patient morbidity have led to the development of nonablative procedures that target dermal collagen without damaging the epidermis.
Concerns regarding resource expenditures have been expressed about the @number@ NIA-AA Sponsored Guidelines for neuropathologic assessment of Alzheimer disease ( AD ) and related dementias.
Concerns regarding SFA and other fatty acids found in dairy products are also reviewed in relation to different forms of dairy products.
Concerns were expressed regarding the financial situation and lack of medical care in higher age.
Concerns were expressed toward technologies that were difficult to use with aging-related changes , privacy and perceptions of technology.
Concerted efforts are needed to improve the quality of medication use by focusing on clinically significant anticholinergic agents.
Concerted efforts are needed to optimize potentially inappropriate anticholinergic medication use in older adults.
Concluding , both types of training were effective in reducing BMI values in hypertensive older subjects.
Concluding from the data presented so far , chronologic aging should not be used as a factor for physiological changes in the human choroid.
Concluding , Th1 response to H. pylori infection varies according to the age and seems to have determinant implication in the H. pylori infection outcomes.
Concluding , this paper reinforces the theory that the capitalist societies attach excessive value to the work in the human being life.
Conclusion.
CONCLUSION.
CONCLUSION.
CONCLUSION.
CONCLUSION.
CONCLUSION.
CONCLUSION : 25OHD levels ≥20 ng / ml are needed for a better muscle function and strength.
CONCLUSION : 25 ( OH ) D was similarly inversely related to all-cause mortality in men and women.
CONCLUSION : AA and DHA were mainly associated with cardiometabolic risk.
CONCLUSION : A better understanding of perioral aging leads to a simple classification for the aging lips.
CONCLUSION : A better understanding of the histology of fractional laser resurfacing will help to optimize clinical outcomes.
CONCLUSION : Ablative fractional CO₂ laser resurfacing was overall safe and effective for skin rejuvenation and acne scars in Asians.
CONCLUSION : Ablative fractional resurfacing is a safe and potentially effective modality for the treatment of CO2 laser induced hypopigmentation on the face.
CONCLUSION : About half of the elderly patients show improvement in postoperative cognitive performance after oncological surgery , whereas @percent@ show cognitive decline.
CONCLUSION : A brief , eight-item version of the EXIT25 may be an effective and efficient screening for executive dysfunction among older adults.
CONCLUSION : A brief GEMC intervention had a significant impact on EM resident knowledge of critical geriatric topics.
CONCLUSION : A brief mailed intervention may be an effective approach to intervening with at-risk drinkers aged @number@ and older.
CONCLUSION : A brief training in aging-related health significantly increased police officers ' self-reported knowledge and skills.
CONCLUSION : Accelerometry-based PA levels were strongly associated with MMD and PMMD events in older adults with limited mobility.
CONCLUSION : According to our data there is a consistence between Turkish Statistical Institute data and our patients ' data on age.
CONCLUSION : According to our observations , As exposure was associated with bone metabolism.
CONCLUSION : According to the gender characteristics of hyoid bone , the data of hyoid bone can provide helps for forensic practices.
CONCLUSION : According to these results , physical capacities are moderately associated with functional autonomy among independent older adults , especially women.
CONCLUSION : Accumulating white matter changes in advanced age are likely driven by small-vessel ischemic disease.
CONCLUSION : Accurate identification of obesity , systemic inflammation , and atherogenic lipid profile is key to assessing the risk of cardiometabolic diseases.
CONCLUSION : ACEs have persistent and multifaceted effects on suicidality in late life.
CONCLUSION : Achieving BPT does not predict any outcome of interest on its own.
CONCLUSION : A clear increase of collagens I and III and a decrease of elastic fibers were observed in the lamina propria of vocal folds.
CONCLUSION : ACLR provides symptomatic relief and restoration of function for patients greater than @number@ years of age.
CONCLUSION : A combined confluent and fractional-ablative @number@ nm Er : YSGG laser treatment improves photodamaged skin for at least @number@ months.
CONCLUSION : A consensus emerged to propose the development of a disease-modifying strategy in VCI and PSCI based on pleiotropic pharmacological and non-pharmacological approaches.
CONCLUSION : A considerable proportion of inhabitants in Golestan have CKD-S3-5.
CONCLUSION : Acromegaly may impair cognitive functions , functional mobility and instrumental daily living activities in the geriatric population.
Conclusion : Actigraph measures of sleep disturbance are associated with higher daytime cortisol among older adults.
CONCLUSION : Active driven visual feedback balance training is effective in improving functional performance and dynamic balance in older adults.
CONCLUSION : Acute care in-hospital mortality following hip fractures remains high and is consistent across academic and community hospitals.
CONCLUSION : Adding oxi-inflammatory load to cardiovascular risk scores may be useful for determining risk of cognitive impairment in very old adults.
CONCLUSION : Additional research is needed to evaluate the benefit of an exercise and lifestyle program that targets cognitive health in those with T2DM.
CONCLUSION : Additional studies are necessary to pinpoint further the determinants and mediators of this relationship.
CONCLUSION : A decrease in leisure activity participation and the presence of constraints do not automatically translate into low levels of leisure satisfaction.
CONCLUSION : A decreasing incidence of LDH with aging occurs in the elderly.
CONCLUSION : A definition of optimum function was developed from a synthesis of the literature's common themes.
CONCLUSION : Adequate calcium intake throughout lifetime is important for bone health and the prevention of osteoporosis and related fractures.
CONCLUSION : ADHD in old age is related to being divorced / never married and loneliness but not to work participation.
CONCLUSION : Adherence to the recommended levels of leisure-time aerobic and muscle-strengthening PA is lower in older than middle-aged cancer survivors in the United States.
CONCLUSION : Adiposity traits share a substantial degree of commonality , but there is considerable specificity across the adiposity variance space.
CONCLUSION : Adoptees have an increased all-cause mortality compared to the general population.
CONCLUSION : Adopting healthy lifestyle behaviours may markedly increase lifespan.
CONCLUSION : Advanced age is not a contraindication for cataract surgery.
CONCLUSION : Advanced age seems to be a predictor of poor response to treatment in obese outpatients treated by conventional medical therapy.
CONCLUSION : Advancing age among an ethnically diverse population of healthy women is associated with significant decreases in eyelash length , thickness , and darkness.
CONCLUSION : Adverse childhood experiences are associated with deleterious mental health effects in later life.
CONCLUSION : Adverse reactions seen in the glabella are overwhelmingly product associated and to a lesser extent location associated.
CONCLUSION : Aerobic exercise training improved the aerobic fitness and OT in elderly subjects.
CONCLUSION : Aerobic training at a moderate-vigorous intensity within a multimodal rehabilitation program for patients with exhaustion disorder facilitated episodic memory.
CONCLUSION : After adjustment for other risk factors , suicide was strongly associated with cancer but not with other disabling , potentially fatal conditions.
CONCLUSION : AG11 appears to be an attractive scaffold for further development of a structurally simpler new anti-microtubule agents.
CONCLUSION : AGE accumulation measured in the skin indirectly with autofluorescence might be associated with incisional hernia.
CONCLUSION : Age and anthropometric parameters have significant independent influence on TSH concentrations after rhTSH injection in both groups.
CONCLUSION : Age and disorder of oral function may be significant predictors of improved functional capacity after rehabilitation for elderly inpatients.
CONCLUSION : Age and gender affect olfaction in Chinese adults as measured by standard testing methods used in other human populations.
CONCLUSION : Age and injury severity rather than antithrombotic agent intake are associated with adverse acute outcome such as GOSE in hospitalized elderly TBI patients.
CONCLUSION : Age and sex are important factors affecting the pharmacokinetics of paracetamol.
CONCLUSION : Age and tactile perceptual abilities have additive effects on the acceptance of creams with different textures when applied to the forearm.
CONCLUSION : Age-associated DNA methylation changes may alter regulatory mechanisms and signaling pathways that predispose to autoimmunity.
CONCLUSION : Age , but not CCI , was significantly associated with less favorable neurological outcomes in patients with OHCA after adjusting important covariates.
CONCLUSION : Age-comparative self-rated health predicted death in older people from a non-Western setting although the association was less marked than in Western settings.
CONCLUSION : Age-dependent changes occur in ONH topography detectable with the HRT.
CONCLUSION : Age does not seem to be a significant predictor for cerebral vasospasm after subarachnoid hemorrhage.
CONCLUSION : Age , gender and previous work experiences as health care assistants did not impact on students ' willingness to work in elderly care.
CONCLUSION : Age has no effect on the rate of intraoperative complications during phacoemulsification surgery.
CONCLUSION : Ageing influences the diameter , surface topography , hardness , loss modulus , storage modulus and tactile perception of human hair.
CONCLUSION : Ageing is an independent risk factor for the induction of AA amyloidosis complicating RA.
CONCLUSION : Ageing male SHRs in contrast to the female SHRs , better mimic the chronic heart failure in humans produced by chronic hypertension.
CONCLUSION : Ageing with LEoP affected daily life to a great extent.
CONCLUSION : Age is a determining risk factor for pure LA and patients with age older than @number@ years are at high risk of LA.
CONCLUSION : Age-related decreases in muscle mass were trivial , especially in women , but the quality of muscle decreased with aging in both sexes.
CONCLUSION : Age-related deficits in the postural control system seem to be primarily responsible for the observed results.
Conclusion : Age-related muscle anabolic resistance is exacerbated in obese inactive individuals , with no apparent detriment to muscle mass.
CONCLUSION : Age should be taken into consideration in selection of appropriate ECG criteria for LVH detection.
CONCLUSION : Age was the most important influence on hearing thresholds for the noise and control groups.
CONCLUSION : Aging ( age ≥ @number@ ) is a risk factor for CIN in Japanese.
CONCLUSION : Aging and severe EE were common associated factors , although there were more associated factors in esophageal strictures than esophageal ulcer bleeding.
CONCLUSION : Aging decreases the chances of return to donation and increases the time interval between donations.
CONCLUSION : Aging does not diminish the increase in muscle protein synthesis following a high-quality protein rich meal and bout of resistance exercise.
CONCLUSION : Aging , hypertension , obesity and abnormal glucose metabolism are positive factors for inter-ankle SBP difference.
CONCLUSION : Aging-in-place for French-speaking seniors living in socio-linguistic minority communities requires concerted efforts from family members , the community and the government.
CONCLUSION : Aging in water resulted in degradation of the resin-dentin bond , as demonstrated by the increase of the zone of exposed collagen.
CONCLUSION : Aging leads to declining tongue pressure and motor function of the lips.
CONCLUSION : Aging-mimic T cell mice produce increased levels of IL-17 , which stimulates the pro-inflammatory NF-κB pathway in prostate epithelial cells.
CONCLUSION : Aging , not age-related chronic , low-grade inflammation , determines the vascular responses to acute inflammation.
CONCLUSION : Aging with a related increase in iron concentration probably does not affect the visibility of nigrosome @number@ at 7T SWI MRI.
CONCLUSION : A good nutritional-status trajectory after hip fracture was associated with better cognitive function.
CONCLUSION : A higher adherence to the MedDiet might be associated with better cognitive function.
CONCLUSION : A higher intake of insoluble fibre could play an important role in the control and management of hypertension , lipid profile and MetS.
CONCLUSION : A higher omega-3 index was correlated with larger total normal brain volume and hippocampal volume in postmenopausal women measured @number@ years later.
CONCLUSION : A higher-quality diet may reduce root caries risk in older men.
CONCLUSION : A higher serum level of total cholesterol was significantly correlated with APOE E4 status in a cognitively normal , nondiabetic aging population.
CONCLUSION : A high percentage of old nursing home residents suffer from weight loss and this is associated with several potentially modifiable nutritional risk factors.
CONCLUSION : AIT improves aerobic capacity and efficiency by depressing aggregability and enhancing deformability of erythrocytes in patients with HF.
CONCLUSION : ALA-IPL PDT has superior rejuvenation effects over IPL alone in Chinese subjects.
CONCLUSION : A large number of AD patients , predominantly females , live alone with severe cognitive and functional impairment.
CONCLUSION : A lateralized tibial tubercle is a relevant anatomic factor in the young athlete and in the adult patient with lateral patellar instability.
CONCLUSION : Albuminuria is prevalent among HIV-infected patients receiving stable antiretroviral therapy.
CONCLUSION : Alcohol abuse is a significant risk factor for population health of Arkhangelsk city.
CONCLUSION : Alcohol use trajectories characterized by persistent unhealthy drinking are associated with more advanced HIV disease severity among HIV-infected veterans in the United States.
CONCLUSION : Aldehyde content of premium quality vinegars is a function of both ageing time and raw material.
CONCLUSION : Alexithymia might be an important searching domain of behavioral-psychological symptoms in people with cognitive problems beyond aging.
CONCLUSION : ALGIB seems to occur frequently in Portugal with a low mortality rate.
CONCLUSION : All four dynamometers showed excellent results regarding their laboratory tested accuracy.
CONCLUSION : All materials revealed comparable wear resistance.
CONCLUSION : All perceived stresses are not equal in their impacts on subsequent depressive symptoms.
CONCLUSION : All the restorative systems evaluated presented stable bond strength after one year of storage.
CONCLUSION : All the women used different cultural discourses to make meaning of UI and continuously negotiated these meanings.
CONCLUSION : All types of AF had a high prevalence.
CONCLUSION : ALM distinguishes the risk of mortality among prefrail and frail older adults.
CONCLUSION : Almost all hospices and a majority of nonhospice PC programs serve patients with dementia.
CONCLUSION : Almost half of the study population had a substantially increased HR of disability , as compared to the reference BMI / WC categories.
CONCLUSION : Almost one-third of persons with paraplegia were eligible for cardiovascular disease risk intervention according to authoritative assessment tools.
CONCLUSION : Almost one-third of the adults aged ≥ @number@ years attending primary care centers with subjective cognitive complaints were affected by mild cognitive impairment.
CONCLUSION : Almost two-thirds of nursing home patients have some degree of anticholinergic burden.
CONCLUSION : Although age is not modifiable , several other factors associated with SA are.
CONCLUSION : Although analyses were based on a selection of patient records , the number and nature of rehabilitation goals differ significantly with age.
CONCLUSION. Although cause-effect relationship cannot make clear , some of desirable health practices and aging were closely related to psychological wellbeing judged by GHQ12.
CONCLUSION : Although children were presumably metabolically similar , we found strong associations of insulin and leptin with the metabolite profile.
CONCLUSION : Although estimates decrease with age , measures of overall and central adiposity predict incident heart failure among community dwelling older adults.
CONCLUSION : Although generally satisfied with abobotulinumtoxinA , when given a choice between abobotulinumtoxinA and onabotulinumtoxinA , the majority of patients favored the latter.
CONCLUSION : Although MB may lead to myocardial ischemia during stress , its clinical presentation and electrocardiographic findings are not specific.
CONCLUSION : Although most older adults completed GST testing , estimates were not interpretable in almost @percent@ due to prolonged perception time.
CONCLUSION : Although not statistically significant , energy and macronutrient intakes increased when volunteers were present.
CONCLUSION : Although older people varied widely in tactile sensitivity , our results show that tactile thresholds increased with age.
CONCLUSION : Although reasonably low , the IPS indicates that the rehabilitation structures analysed could be used more efficiently.
CONCLUSION : Although significantly interrelated , DXA and CT variables should not be used interchangeably since they have different quantitative and physiological significance.
CONCLUSION : Although support services are available to dementia caregivers , CIND caregivers also expend considerable time and experience strains.
CONCLUSION : Although the reasons why older adults with cancer accepted or declined treatment varied considerably , the most consistent determinant was physician recommendation.
CONCLUSION : Although the TM measurements were not correlated with age , the TM interface shadow area increased with age.
CONCLUSION : Although weight loss has been recommended for adults with excessive weight regardless of age , weight change might be detrimental in older adults.
CONCLUSION : Altogether these factors also drive this pathologic condition under the general heading of \ "Inflammaging \ ".
CONCLUSION : A marked age-related difference was found in the ability to control attentional focus in response to task instructions.
CONCLUSION : AMD patients with poorer vision engage in significantly less physical activity and take fewer excursions away from the home.
CONCLUSION : A minority of NH residents with advanced dementia received hospice care.
CONCLUSION : Amnesia for loss of consciousness is common in VVS.
CONCLUSION : Among acutely admitted older medical patients , FI-OutRef was strongly associated with long-term mortality.
CONCLUSION : Among CCRC residents , alcohol use may be socially motivated rather than motivated by coping with negative affect.
CONCLUSION : Among Chinese nonagenarians and centenarians , CKD was not directly correlated with cognitive impairment.
CONCLUSION : Among Chinese older people living in a rural community , PAD , carotid artery stenosis , and an increased cIMT are relatively uncommon.
CONCLUSION : Among community-living dyads , a nonpharmacologic biobehavioral environmental intervention compared with control resulted in better outcomes for COPE dyads at @number@ months.
CONCLUSION : Among dementia-free subjects , age is an important predictor of cognitive function level and cognitive decline.
CONCLUSION : Among healthy older adults , dietary patterns do not appear to be related to depression.
CONCLUSION : Among HIV-uninfected and HIV-infected men of similar social risk behaviors , GFR estimates differed by biomarker and kidney function level.
CONCLUSION : Among individuals aging more than @number@ years included in the study , A-FABP was inversely associated with liver steatosis.
CONCLUSION : Among multi-inflammatory markers , only IL6 had the potential to identify people at increased risk of ADL disability , independently of ethno-racial background.
CONCLUSION : Among nondisabled community-dwelling older adults , the risk of disability increases with the number of areas reported with musculoskeletal pain.
CONCLUSION : Among older adults , anemia is associated with an increased risk of developing dementia.
CONCLUSION : among older adults in São Paulo , women lived longer lives but experienced a higher and more severe disability burden than men.
CONCLUSION : Among older community-dwelling men and women , @percent@ had PAD and @percent@ had borderline or low normal ABI values.
CONCLUSION : Among the analyzed laboratory data , the albumin / globulin rates were the best candidate indicators for individual somatic genomic aging.
CONCLUSION : Among the other chronic comorbidities only depression was associated with a poor HRQoL in PD patients.
CONCLUSION : Among the three EF measures assessed , intraindividual variability but not speed of processing or conflict resolution predicted performance differences in gait speed.
CONCLUSION : A multidisciplinary approach , targeting several different areas , could substantially lower readmissions and hospital costs in a non-terminal general hospital population.
CONCLUSION : A multipronged , adaptive approach led to the successful recruitment of diverse community-residing elders with memory impairment for an intervention trial.
CONCLUSION : An adult grafted liver does not appear to rejuvenate in a pediatric recipient.
CONCLUSION : An adverse association of higher BMI with cognitive function began in adolescence and was restricted to low childhood SEP.
CONCLUSION : Analysis of cross-sectional data from the AIBL study indicates that plasma apoE levels are altered in AD and correlate with AD pathology level.
CONCLUSION : An anticholinergic agent or antidiuretic agent as an add-on therapy in men previously treated with an alpha-blocker improves nocturia including LUTS.
CONCLUSION : An aphorism devised by Hippocrates millennia ago can predict death in the modern era.
CONCLUSION : An automated exercise promotion system deployed from outpatient clinics increased walking among older adults over the short-term.
CONCLUSION AND RELEVANCE : Botanical extracts and vitamins may add to the armamentarium of sun-protective agents.
CONCLUSION AND RELEVANCE : Detailed knowledge of the soft-tissue anatomy of the cheek and lip is critical to accurate surgical planning in local flap reconstruction.
CONCLUSION AND RELEVANCE : Home health care nurses can effectively integrate depression care management into routine practice.
CONCLUSION AND RELEVANCE : IVF with PGD is a viable option for couples who wish to avoid passing the disease to their offspring.
CONCLUSION AND RELEVANCE : The results suggest that TDP-43 is an important brain pathology underlying cognitive decline and dementia in old age.
CONCLUSION : An entirely telephone-delivered intervention was effective in increasing caregiver engagement in community resources and reducing caregiver use of hospital-based healthcare resources.
CONCLUSION : A new role for mtDNA haplogroups emerges from this work.
CONCLUSION : An exponential decrease in human fertility which is independent of the woman's age was observed with male aging.
CONCLUSION : Angular artery cutaneous flap is a good alternative for reconstruction of the oronasal fistula.
CONCLUSION : An increase in serum lycopene after supplementation can reduce oxidative stress which may play a role in endothelial function.
CONCLUSION : An individualized nutritional follow-up performed as home visits seems to reduce readmission to hospital @number@ and @number@ days after discharge.
CONCLUSION : An individualized safe-transportation program can promote behavior change but did not translate to significant differences in weekly mileage after @number@ months.
CONCLUSION : An individually-adapted nutritional counselling did not improve body mass among elderly patients @number@ months after discharge from a rehabilitation institution.
CONCLUSION : An inertial data acquisition system was designed and developed as a low-cost option for monitoring rehabilitation.
CONCLUSION : An infrared device is safe , well tolerated , and minimally effective in treating aged upper arm skin laxity.
CONCLUSION : An intensive exercise program can be implemented in a geriatric rehabilitation setting to improve motor performances in patients with dementia.
CONCLUSION : An interaction between physical activity and erythrocyte EPA content ( percentage of fatty acids ) significantly predicted MCI status in older adults.
CONCLUSION : ankle dorsiflexor strength varied seasonally.
CONCLUSION : Annual rates of postthyroidectomy vocal fold paralyses are decreasing among Medicare beneficiaries with WDTC.
CONCLUSION : An optimistic outlook appears to be a significant predictor of survival among the oldest-old women.
CONCLUSION : A norm for straylight in the pseudophakic eye was developed that is considerably different from the previously published norm for the phakic eye.
CONCLUSION : Antibiotics that target DNA synthesis result in a progressively higher number of resistant isolates among the older population.
CONCLUSION : Anticipated shortages are largely consistent with the projections of the ASCO @number@ workforce study but somewhat more delayed.
CONCLUSION : Antimuscarinic agents are effective in OAB treatment.
CONCLUSION : Antiretroviral therapy can be delivered effectively through community-based treatment settings.
CONCLUSION : A number of DEGs and altered pathways were screened in osteoporosis.
CONCLUSION : An understanding of aging could provide predictive factors to detect the conversion of physiological aging into pathological conditions.
CONCLUSION : A pacemaker implantation performed by an experienced operator is a safe procedure for patients of advanced age.
CONCLUSION : Apathy and depression are both associated with objective measures of PI , and apathy appears a stronger predictor of PI than depression.
CONCLUSION : Apathy frequently occurred in community-dwelling older persons , also in the absence of depressive symptoms and cognitive impairment.
CONCLUSION : A pilot study showed that preliminary normative CST , MT , and MV values were obtained by Cirrus high-definition optical coherence tomography.
CONCLUSION : APOE ϵ4 is directly related to positive affect and is related to negative affect in interaction with life events.
CONCLUSION : Apo E ε4 positivity predicted four cognitive scores measured every @number@ months over @number@ months.
CONCLUSION : Apolipoprotein and lipid profiles in this First Nation population suggest high cardiovascular risk.
CONCLUSION : Appearance-based video education appears to be effective in promoting sunscreen use and knowledge in adolescents.
CONCLUSION : Appendiceal diameter measured on ultrasound is normally distributed in children and does not depend on age.
CONCLUSION : Application of autologous PRP is an effective method for enhancing wound healing and reducing transient adverse effects after FxCR treatment.
CONCLUSION : Apprehensive gait promoted greater activation of thigh muscles and older adults had greater cocontraction of knee and ankle stabilizer muscles.
CONCLUSION : Appropriately assessing the aging neurosurgeon is important to protect patient safety and also maximize the capacity of an aging neurosurgical workforce.
CONCLUSION : Approximately @number@ out of @number@ older adults demonstrate frailty.
CONCLUSION : Approximately @percent@ of residents had the intention of using the health consultation services provided in the community.
CONCLUSION : A quantitative stroke risk-weighted measure of IB explained variability in baseline executive function performance and associated with decline in memory.
CONCLUSION : A quarter of depressed older patients is physically frail , especially the most depressed group.
CONCLUSION : Areas of cognition associated with ghrelin level were similar to the pattern of deficits observed in early Alzheimer's disease.
CONCLUSION : A reduced OGG1 expression was correlated with hypermethylation of a CpG island of OGG1 in lens cortex of ARC.
CONCLUSION : A reflective stationary intervention delivered in-residence could be an ideal mechanism to decrease stress in low-income older adult's lives and improve their health.
CONCLUSION : A relationship between age and OAB was observed , but metabolic syndrome did not show a clear association with OAB.
CONCLUSION : Arrhythmias are common in TOF patients and increase mortality risk.
CONCLUSION : Arterial stiffness is an important indicator of atherosclerosis and arterial aging in patients with ESRD.
CONCLUSION : Arterial stiffness is associated with cerebral small vessel disease and decreased cognitive function.
CONCLUSION : Artificial aging had a significant effect on the LTF value of the tested specimens compared with the resin cements used.
CONCLUSION : ART treatment-naive HIV-positive individuals have significantly older DNAm age compared to HIV-negative individuals in the Veterans Aging Cohort Study cohort.
CONCLUSION : As antiretroviral treatment cohorts mature , the proportion of patients who are elderly will inevitably increase.
CONCLUSION : As a result we created a neurosurgical spine society to represent neurosurgeons who were otherwise almost absent from the political decision-making processes.
CONCLUSION : As expected , mould-active azoles prevented IFIs , particularly invasive aspergillosis , more effectively than fluconazole in alloHCT recipients.
CONCLUSION : A short e-learning module focused on geriatric pharmacotherapy can significantly improve doctors ' prescribing knowledge and confidence with regards to older patients.
CONCLUSION : A significant difference in extracolonic Lynch syndrome-associated cancer was evident between suspected familial colorectal cancer type X and Lynch syndrome.
CONCLUSION : A significant increase in annual number of HZ cases was observed , driven largely by demographic factors.
CONCLUSION : A significant proportion of HF in older adults develops without prior vascular disease.
CONCLUSION : As increasing numbers of older adults are discharged to postacute care facilities , they face high-risk care transitions.
CONCLUSION : A single MFU-V treatment provided significant aesthetic improvement for moderate-to-severe décolleté lines and wrinkles for at least the 180-day duration of the study.
CONCLUSION : A sizable proportion of healthy older adults experienced walking speed decline over an average of @number@ years.
CONCLUSION : A small but statistically significant increase in IOP with age was detected when excluding eyes that had undergone cataract surgery.
CONCLUSION : a small number of instruments have been validated for screening for dementia in general hospital.
CONCLUSION : As NO production has many positive pleiotropic effects in the cardiovascular system , such an interaction could be utilized for designing molecular therapeutics.
CONCLUSION : ASOBPR may be an early marker of risk of dementia in older adults living in the community.
CONCLUSION : As prior disability status predicts future disability status , interventive strategies should be aimed at preventing disability in the first place.
CONCLUSION : Assessment of bony orbit depth could offer new tool for selecting infraorbital groove injection technique.
CONCLUSION : Assessment of sex , race and age related differences in microstructure requires measurement of anatomically equivalent regions.
CONCLUSION : Assessment of third molar development was found to be a reliable method for age estimation of individuals between @number@ and @number@ years.
CONCLUSION : Assessments of functional mobility , fall risk and cognition should be an integral part of every comprehensive geriatric assessment.
CONCLUSION : Association between body fat percentage and maximal walking speed was strongest between the ages of @number@ and @number@ years.
CONCLUSION : As the spread of prenatal genetic screening continues , providers will increasingly need to update their practice to accommodate new screening modalities.
CONCLUSION : Astragaloside can protect the skin from UVA irradiation.
CONCLUSION : A strong association was found between long-term HRT use and low CAC.
CONCLUSION : A stronger degree of ikigai is significantly associated with a lower risk of incident functional disability.
CONCLUSION : A structured telephone intervention can benefit dementia caregivers in terms of self-efficacy and caregiving burden.
CONCLUSION : A substantial number of QIs is available to assess the quality of community care for older people.
CONCLUSION : A substantial percentage of hospital readmissions from SNFs are rated as potentially avoidable.
CONCLUSION : A substantial proportion had poor SRH prior to and during cancer treatment.
CONCLUSION : A substantial proportion of older veterans treated and released from a VAMC ED returned to the ED or were hospitalized within @number@ days.
CONCLUSION : A testosterone and a high calorie nutritional supplement intervention did not improve the frailty levels of under-nourished older people.
CONCLUSION : A theoretical definition and a model of resilient ageing were developed.
CONCLUSION : At inclusion , soluble-CIADIS weighted score was independently associated with a confirmed eGFR less than @number@ ml / min per @number@ m.
CONCLUSION : At reduced SNRs , cues from DBM enabled the listener to repeat the heard VCV syllables.
CONCLUSION : A two region of interest analysis of iron is a much more sensitive means to evaluate iron content change over time.
CONCLUSION : Augmented compartmental loads and structural lesions increased the risk of the presence or progression of BMLs.
CONCLUSION : A U-shaped association between blood pressure and cognitive function in an elderly Chinese population was found.
CONCLUSION : Autonomic changes critically regulate termination of PAF , which is modulated by aging.
CONCLUSION : Available data suggest that clomiphene is an efficient and convenient alternative to testosterone replacement therapy in a substantial subset of patients with LOH.
CONCLUSION : A validated clinical photoaging scale for forearms with internal consistency , reliability , and validity was developed.
CONCLUSION : A variety of tools is used to assess frailty of older patients in clinical practice highlighting the need for standardisation and guidelines.
CONCLUSION : AVC significantly increased the risk of PMI after elective coronary intervention.
CONCLUSION : Averaging more than @number@ grams of alcohol per day may increase risk of dementia.
CONCLUSION : A ' within a physical activity intervention affects change in physical activity via change in views on ageing.
CONCLUSION : Baastrup disease occurs with high frequency among the elderly.
CONCLUSION : Background gradients affect the DT-MRI measurements in AD patients.
CONCLUSION : Balance confidence is a fall risk predictor , and thus a critical component of fall risk assessment.
CONCLUSION : Baroreflex sensitivity may represent an intermediate goal for prevention of ambulatory hypertension at early stage.
CONCLUSION : Basal LES pressure is elevated and swallow-induced relaxation impaired in elderly dysphagic patients.
CONCLUSION : Based on all studies that investigated both LC and BMI , LC was positively correlated with the BMI.
CONCLUSION : Based on data available in a community-based geriatric dental clinic , dementia was not associated with tooth loss.
Conclusion : Based on EWGSOP criteria , prevalence of sarcopenia is extremely high among older adults on admission to acute hospital wards.
CONCLUSION : Based on the results of this study , desirable u-health services from the perspective of healthcare professionals were proposed.
CONCLUSION : Based on the results of this systematic review , increased adhesion could be expected after physicochemical conditioning of zirconia.
CONCLUSION : Based on these data , we propose that bakuchiol can function as an anti-ageing compound through retinol-like regulation of gene expression.
CONCLUSION : Baseline CFL severity , age , and gender may predict fan pattern.
CONCLUSION : Baseline restricted life-space was associated with greater risk of hospital readmission within @number@ days after hospital discharge.
CONCLUSION : BD patients with VR may also be at risk for greater decline in inhibitory performance , but not PS , with age.
CONCLUSION : Because different types of nasolabial folds require different treatments , it is crucial to accurately assess and correctly classify the conditions.
CONCLUSION : Being admitted to ED for social disorders and living in institution predicted a higher risk of in-hospital mortality.
Conclusion : Being overweight in older age was not protective of mobility function.
CONCLUSION : Better diet quality at midlife seems to be strongly linked to greater health and well-being in persons surviving to older ages.
CONCLUSION : Better viewing efficiency was observed in younger individuals compared to older individuals.
CONCLUSION : Beyond chronological age , the subjective experience of age is associated with cognitive aging.
CONCLUSION : Bile acids induce the expression of pro-inflammatory cytokines in hepatocytes in Abcb4- / - mice that initiates an inflammatory response.
CONCLUSION : Biodemographic analyses could provide important information about the properties of genes affecting phenotypic traits.
CONCLUSION : blue and red light have similar efficacy as the light source for MAL-PDT when combined with other light sources.
CONCLUSION : BMDs at femoral neck and total hip decrease with age.
CONCLUSION : BMI is significantly associated with all-cause and cardiovascular mortality in institutionalized elderly patients.
CONCLUSION : BMLs detected by MRI were highly prevalent in this elderly Asian population.
CONCLUSION : Body composition assessed using BIA might be associated with knee OA , and be a noninvasive tool for diagnosis of knee OA.
CONCLUSION : Body fat has a negative influence on functional performance , even among active elderly women.
CONCLUSION : Body mass index , and not waist circumference , better predicts Chinese senior adults ' hypertension.
CONCLUSION : Bone geometry of the metacarpal shaft is altered in RA patients compared to healthy controls.
CONCLUSION : Bone mineral changes are present in the greater tuberosity of shoulders with rotator cuff disease both with and without full-thickness tears.
CONCLUSION : Bone-muscle relationship was more prominent in men than in women.
CONCLUSION : BoNT / A injection rapidly improved periorbital wrinkles , but the effect decreased up to week @number@
CONCLUSION : Both a sex difference and a sex difference of age-related change in hip abductor muscle properties were demonstrated.
CONCLUSION : Both deterioration and improvement in ADL over the course of @number@ years increased the risk for falls in a general elderly population.
CONCLUSION : Both experiments showed that GS has a positive effect on epidermal and dermal markers associated with age.
CONCLUSION : Both HFA 10-2 and Octopus G1programs showed CVFD not present at HFA 24-2 test although the agreement was moderate.
CONCLUSION : Both HIV and aging contribute to immune dysfunction , morbidity and mortality.
CONCLUSION : Both interventions were feasible and equally effective to increase long-term engagement in PA , irrespective of the type of supervision.
CONCLUSION : Both investigated antioxidant factors - PON1 activity and anti-ox LDL level , could play an important role in aging.
CONCLUSION : Both MLCK and ROCK contribute to carbachol-induced contractions of human detrusor smooth muscle.
CONCLUSION : Both nutritional and genetic factors are related to lipid profile.
CONCLUSION : Both settings resulted in moderate but significant improvement in dyschromia , although only HF treatment improved rhytides.
CONCLUSION : Both specific and global cognitive changes are witnessed in PD and AD.
CONCLUSION : Both speed and accuracy of performance on measures of IADL are valuable indices for early detection of functional change in MCI.
CONCLUSION : Both SSR and heat induced MMP-1 expression in dermal fibroblasts but through different pathways.
CONCLUSION : Both techniques proved to be in agreement and have good intra- and interobserver reliability.
CONCLUSION : Both training groups improved RT after the interventions and sustained these improvements over @number@ weeks , but showed no reductions in postural sway.
CONCLUSION : Both treatments increased similarly the removal from plasma of chylomicron and remnants in CHD patients.
CONCLUSION : Botulinum toxin type A is a safe and effective treatment for some cosmetic problems.
CONCLUSION : BP tends to increase over time in active elders , regardless of changes in body composition or level of physical activity.
CONCLUSION : Brain inflammatory changes remain ubiquitous among HIV-infected individuals , whereas neuronal injury occurs predominantly in those with cognitive impairment.
CONCLUSION : Brain network efficiency measures may represent different aspects of underlying network organization depending on the population and behaviors in question.
CONCLUSION : BRRT improves verbal memory-learning and global cognitive impairment which are associated with increased TOI values on frontal cortex of both sides.
CONCLUSION : BTX-A is a simple procedure that may be of value in temporarily improving the cosmetic appearance of pachydermia in patients with PDP.
CONCLUSION : B-type natriuretic peptide , not CRP , substantially improved AF risk prediction beyond clinical factors in an independently replicated , heterogeneous population.
CONCLUSION : B vitamin status does not influence the risk of overall cognitive dysfunction in ε4 allele affected older adults.
CONCLUSION : C9ORF72 carriers with well-defined delusions likely associated with additional pathologies and parietal atrophy in neuroimaging.
CONCLUSION : CaHA filler is safe , efficacious and well-tolerated when used appropriately.
CONCLUSION : CaHMB improved strength and MQ without RE.
CONCLUSION : Cardiac performance should be closely monitored in women treated with trastuzumab.
CONCLUSION : CARDIoGRAM is poised to contribute to our understanding of the role of common genetic variation on risk for CAD and MI.
CONCLUSION : Cardiovagal function assessed by HRDB is associated with sural SNAP amplitude in healthy subjects.
CONCLUSION : Careful restriction of expected CRC deaths by an incidence-based mortality approach is indispensable for deriving valid screening effect estimates.
CONCLUSION : Caregivers of care recipients without dementia or disability accounted for the largest absolute number of helpers.
CONCLUSION : Caregivers of patients with dementia and diabetes face extraordinary challenges managing both conditions and the accompanying BPSD.
CONCLUSION : Carer concerns for those diagnosed with dementia shift with the progression of cognitive changes , with concerns declining over the 10-year period.
CONCLUSION : Carers should be considered key partners in mental health care planning that crosses service sectors.
CONCLUSION : Caries experience was highly prevalent in our sample.
CONCLUSION : Caring for older adults in a global context requires knowledge and understanding of cultures and their values and practices.
CONCLUSION : CARS2 is a novel disease gene associated with a severe progressive myoclonic epilepsy most resembling MERRF syndrome.
CONCLUSION : Cataract is still the first cause for blindness and low vision.
CONCLUSION : CCR is associated with superior survival outcomes than Std-ALS for OHCAs in people aged @number@ and older.
CONCLUSION : Central arterial pressure is associated with the decline of age-related renal function.
CONCLUSION : Central auditory tests showed worse performance with aging.
CONCLUSION : Cerebellar atrophy contributes to Alzheimer's clinical progression but mostly at the late stage of the disease.
CONCLUSION : CfPWVsub , cfPWVdir0.8 , and aoPWVestim are reasonable surrogates for aoPWVinv.
CONCLUSION : Changes in coping style predicts future well-being ; however , coping remains malleable with age and maladaptive strategies can be effectively targeted.
CONCLUSION : Changes in serum magnesium and phosphate levels do not correlate with changes in muscle strength in older hospitalised patients.
CONCLUSION : CHD , smoking and obesity may have a role in the development of long-lasting psychological distress from midlife to old age.
CONCLUSION : Chemical peels are a cost-effective and reliable treatment for a variety of aesthetic and medical skin conditions.
CONCLUSION : Childhood adversity may predispose individuals with high neurobiological sensitivity to a lifetime of maladaptive coping.
CONCLUSION : Children aged 8-10 years had the highest severity of vocal deviation.
CONCLUSION : Children presented longer narratives in the book context.
CONCLUSION : Children with ALL are at risk of becoming overweight / obese early in treatment.
CONCLUSION : children with SLI presented deficit in phonological representation when compared with children with NLD.
CONCLUSION : Choosing the right anatomical site to insert a peripheral venous catheter is important to decrease phlebitis rate.
CONCLUSION : Chronic ADF in rats results in development of diastolic dysfunction with diminished cardiac reserve.
CONCLUSION : Chronic exposure to UV may damage skin barrier function and therefore play a role in skin photoaging process.
CONCLUSION : Chronic hyperparathyroidism has been linked with increased all-cause mortality.
CONCLUSION : Chronic RAS activation is not sufficient to cause insulin resistance in mice.
CONCLUSION : Chronic treatment with CE increases ER-α but not ER-β expression in cerebral microvessels of OVX rats.
CONCLUSION : CHT-RT may cause lung injury in a small , but significant fraction of HL patients.
CONCLUSION : CIA is common in pediatric patients.
CONCLUSION : Cinacalcet treatment was associated with a decline of renal function in kidney transplant recipients with persistent HPT.
CONCLUSION : Circulating ferritin levels showed sex-specific prognostic patterns.
CONCLUSION : Circulating oxLDL amplifies the effect of GGT on mortality in the elderly.
CONCLUSION : Circulating T cells expressing markers of activation and inflammatory cytokine levels are independently correlated with PFT abnormalities in HIV-infected persons.
CONCLUSION : CK is a potential agent for the prevention and treatment of skin photo-aging.
CONCLUSION : Clinical and biocompatibility data from longer than @number@ years support the favorable clinical safety profile of BDDE-crosslinked HA and its degradation products.
CONCLUSION : Clinical and radiologic evidence give a high suspicion of progeria in the index patient.
CONCLUSION : Clinical , legal and ethical literature support this result and thereby re-establishes a basis for the recognition and respect of an individual's dignity.
Conclusion : Clinical speech recognition outcomes for adult implant users relate to the ability of these users to process phonological information.
CONCLUSION : Clinical suspicion is called for if individuals with ADL limitations attribute them solely to ' old age'.
CONCLUSION : Clinical use of the orthodontic wires increases their surface roughness and the level of friction.
CONCLUSION : Clinicians should assess the current use of drugs with anticholinergic properties in the elderly , particularly in patients presenting for memory evaluation.
CONCLUSION : Cocaine-induced abnormal increases in the number of astrocytes may cause disruption in neuron-glia signaling and contribute to synaptic impairment in the CNS.
CONCLUSION : Coffee and polyphenol consumption was associated with low facial pigmented spots in Japanese middle-aged females.
CONCLUSION : Coffee consumption may be protective against periodontal bone loss in adult males.
CONCLUSION : Cofilin rods and aggregates signify events initiated early in the pathological cascade.
CONCLUSION : Cognitive dysfunction was not a detriment to improvement in symptoms of psychotic major depression in our geriatric patients.
CONCLUSION : Cognitive function is affected in COPD patients with an altered nutritional status when compared to those with a normal nutritional status.
CONCLUSION : cognitive impairment in the absence of manifest dementia is an important independent predictor of mortality , especially among men.
CONCLUSION : Cognitive impairment in the elderly living in long-term care facilities was more pronounced and frequent in obese individuals.
CONCLUSION : Cognitive impairment is a common finding in hemodialysis patients.
Conclusion : cognitive impairments seem associated with functional decline in hospitalised older people.
CONCLUSION : Cognitively stimulating activities did not improve delirium but improved executive function and reduced length of stay.
CONCLUSION : Combined elevations in IL-6 and CRP were associated with the lowest pulmonary function levels in older women.
CONCLUSION : Combined physical and mental activity engagement was associated with better physical function , especially in gait speed.
CONCLUSION : Combining the 6-week EA and standard rehabilitation treatment reduced the spasticity of the elbow for chronic stroke survivors.
CONCLUSION : common consultations motifs were similar in urban and rural settings , with some relevance of lower gastrointestinal tract disease.
CONCLUSION : Common processes may underlie different psychosocial interventions for dementia.
CONCLUSION : Community-dwelling men and women with very low plasma PK were more likely to have progression of articular cartilage and meniscus damage.
CONCLUSION : Community-dwelling older people were more physically active on days when they moved through greater life-space areas.
CONCLUSION : Community involvement provides older women with mental health benefits regardless of individual relationship level.
CONCLUSION : Community pharmacists performed CDSS-based interventions to prevent potentially inappropriate ( dosing of ) antibiotics in elderly patients with renal impairment.
CONCLUSION : Comorbidity between gastrointestinal conditions and anxiety was associated with unmet mental health service needs.
CONCLUSION : Compared with black people and white people , the older Chinese have less muscle mass , weaker grip strength and slower gait speed.
CONCLUSION : Compared with females , males demonstrate lower response rates on wrinkle severity scales in studies on all @number@ available botulinum toxins.
CONCLUSION : Compared with GP clinics , polyclinics may be more suited to provide case-finding services for the detection of CI in primary health care.
CONCLUSION : Compared with ratings of memory , similar assessments of word-finding / language difficulties were relatively inaccurate , and thus poor predictors of impairment.
CONCLUSION : Compared with the creatinine-based equations , the CKD-EPI creatinine-cystatin C equation is more suitable for the elderly Chinese population.
CONCLUSION : Compared with the middle-aged cohort , the middle-old and the old-old cohort showed an increased short-term and long-term mortality rate.
CONCLUSION : Comparison of the outcomes from this study with the research conducted in @number@ demonstrated an increasing prevalence rate of suspicion for mental disorders.
CONCLUSION : Compensatory covert saccades seen in vHIT correlate with improved performance of DVA-testing in patients with unilateral peripheral vestibular loss.
CONCLUSION : Complaint themes in those with MCI align with the MCI symptom complex , particularly when accompanied with high Aβ load.
CONCLUSION : Computer analysis of athletes ' ECGs should be included in future studies that have greater numbers , more diversity and adequate end points.
CONCLUSION : Concordance between the therapies proposed during the Tumor Board or after the Geriatric Oncology Consultation and the treatment actually given was satisfactory.
CONCLUSION : Confidence is an important factor in how control beliefs and age are related to memory errors in the misinformation effect.
CONCLUSION : Confounding by LC might often be a minor issue.
Conclusion : Conscientiousness mitigated the stress-depressive symptom relationship among U.S. Chinese older adults.
CONCLUSION : Conscientiousness was associated with all @number@ measures of brain integrity , which we tentatively interpret as the effects of personality on brain aging.
CONCLUSION : Consequences of sentinel injury in older adults extend well beyond the period typically considered to be an acute injury episode.
CONCLUSION : Considerable drug-related mortality in people with OUD suggests a need for greater access to overdose prevention and opioid substitution therapy across the lifespan.
CONCLUSION : Considerable variability exists among pediatric rheumatology clinicians regarding when and how to withdraw medications for children with clinically inactive JIA.
CONCLUSION : Considerable variation was found in the self-report of health conditions and behavioral characteristics among those individuals that attended the health fair.
CONCLUSION : Consistency of frequent knee pain is associated with an increased risk of TKR independently of knee pain severity.
CONCLUSION : Consolidation was impaired in aMCI as compared with controls.
CONCLUSION : Constricted life space is associated with greater risk of death in older community-based persons.
CONCLUSION : Construct validation provides support for using the DII in research among AA populations.
CONCLUSION : Contact between these people and the health service must inspire confidence for it to prevent suicide.
CONCLUSION : Continuity with patient's PCP or pulmonologist after an acute hospitalization may lower rates of ER visits and readmission in patients with COPD.
CONCLUSION : Continuous in-vitro monolayer culture could efficiently cultivate numerous seeding NPCs , but it is liable to dedifferentiate.
CONCLUSION : Continuous treatment with onabotulinumtoxinA for a mean of @number@ years was associated with very high patient satisfaction.
CONCLUSION : Contrary to the Hispanic paradox , MAs were at greater risk of mortality than EAs.
CONCLUSION : Control beliefs were significantly associated with risk for 4-year mortality ; accounting for these factors improved identification of low-risk individuals.
CONCLUSION : Controlling gait speed and objective evaluation of the visuospatial cognitive tasks helps to determine the level of engagement in the DT tasks.
CONCLUSION : Co-occurrence of delirium , SSD , depression , and dementia in LTC residents appears to affect some 6-month outcomes.
CONCLUSION : COPD is positively associated with disability and mortality risk among US adults aged ≥70 years.
CONCLUSION : Corrected visual acuities and contrast sensitivity were worse in older patients than in younger patients.
CONCLUSION : cortisol level remains stable with advanced age in males despite the decrease in steroidogenic activity and blood ACTH level.
CONCLUSION : Cortisol profiles varied across four diverse populations of older adults.
CONCLUSION : COX-2 expression is significantly higher in chronologically aged and photoaged skin than the normal young skin.
CONCLUSION : Creative dance has a positive effect in different dimensions of functioning and has the potential to contribute to healthy aging.
Conclusion : CRF is associated with cortical GM and total GM volumes in elderly men at increased risk for AD , but not in women.
CONCLUSION : Criteria for awakening of infants from anesthesia need to be developed and agreed.
CONCLUSION : Criteria for MCI , defined using MMSE scores or clinical criteria , can capture individuals at greater stroke risk.
CONCLUSION : Cross-linked carboxymethyl cellulose has been shown to be a safe and effective alternative to the resorbable products currently on the market.
CONCLUSION : Cross-linked CMC hydrogel proves to be an ideal agent for soft tissue augmentation with regard to safety and ease of application.
CONCLUSION : CRRTs vary with age , body sites and gender.
CONCLUSION : CSF can better show the neurodegenerative changes in the brain.
CONCLUSION : Cumulative information across the human genome can be used to characterize individual level risk for obesity.
CONCLUSION : Current evidences show that elder abuse is a common problem in both developed and developing countries.
CONCLUSION : Current preliminary evidence suggests no beneficial effect of NSAIDs on cognition or overall AD severity.
CONCLUSION : Current scientific knowledge is mainly based on observational studies with poor quality data , which report associations but do not prove causality.
CONCLUSION : CVDs impact the survival of NSCLC patients , particularly when multiple co-existing CVDs are present ; the impacts vary by stage and treatment.
CONCLUSION : CVD was an important cause of mortality in this cohort and DM and / or central adiposity were associated with all-cause mortality.
CONCLUSION : CV risk factors influence age-related memory decline in APOE ε4 HMZ.
CONCLUSION : Cyclin D1 / Cdk4 is a critical target of the AKT survival signaling pathway responsible for tumor radioresistance.
CONCLUSION : Cynatine ( ® ) HNS is an effective supplement for improving skin in @number@ days or less.
CONCLUSION : Daily crosswords may be a simple and effective means of bolstering PVF performance in older people.
CONCLUSION : Daily n-3 PUFA supplements consumption was independently associated with less cognitive decline in elderly Chinese.
CONCLUSION : Data collected in PCC allow determining a number of toxicodynetic parameters.
CONCLUSION : dCON cases are characterized by decreased sensitivity to caffeine effects on brain activation and DMN deactivation.
CONCLUSION : Deaths of PD patients who receive DBS are typically unrelated to the disease itself or complications associated with the surgery.
CONCLUSION : Decline in average global cognitive function was evident at least @number@ years before clinical diagnosis of dementia.
CONCLUSION : Decline in executive function was associated with risk of reported and confirmed elder self-neglect.
CONCLUSION : Decline of motor function contributed toward psychological concerns via ADL disability in elderly people with locomotive disorders.
CONCLUSION : Deficits in both temporal envelope and temporal fine structure processing are evident during middle age even while audiometric hearing sensitivity remains normal.
CONCLUSION : Deficits in everyday memory and executive function domains were the strongest predictors of diagnostic conversion to MCI.
CONCLUSION : Defining the concept of complexity of care will facilitate student understanding of the unique health care needs of older adults.
CONCLUSION : Definitive lung SBRT for early-stage non-small-cell lung cancer was efficacious and safe in patients ≥ @number@ years old.
CONCLUSION : Delusions in AD are associated with dysfunction in specific frontal and temporal cortical regions.
CONCLUSION : Demand for radiation therapy is expected to grow @number@ times faster than supply between @number@ and @number@
CONCLUSION : Dementia adds additional complexity to clinical judgements about the acceptability of deception in practice.
CONCLUSION : Dementia is associated with increased complexity in assessed care needs in permanent residential aged care.
CONCLUSION : Dementia is underreported on death certificates as main and contributory causes.
CONCLUSION : Dementia services in NSW hospitals are closely aligned with ACS and SMHSOP , with limited dementia services in hospitals without ACS or SMHSOP.
Conclusion : Demographic and genetic factors , but also prior and current health insults , are linked to OD in old age.
CONCLUSION : De novo spine surgery is associated with an increased incidence of additional spine surgery at the same or distant spine regions.
CONCLUSION : Dependent on the dose , duration of action and quality , IR plays diverse roles in biological systems.
CONCLUSION : Depending on the oncogenic background , CDC25C may reveal protective or oncogenic functions.
CONCLUSION : Depletion of SIRT6 in human chondrocytes caused increased DNA damage and telomere dysfunction , and subsequent premature senescence.
CONCLUSION : Depression prevalence was similar across all depression definitions except for ICD-10 , showing much lower figures.
CONCLUSION : Depression status and sleep quality are strongly influenced by diabetic complications and DM duration in elderly patients.
CONCLUSION : Depressive disorders are significantly higher in COPD patients than controls.
CONCLUSION : Depressive symptoms are not associated with increased mortality rates in general older populations.
CONCLUSION : Depressive symptom scores and negative mood scores decreased significantly over time.
CONCLUSION : Depressive symptoms increase the risk for later dementia in community-dwelling older adults.
CONCLUSION : Depressive symptom was independently associated with increased risk of mild NCD among Chinese elderly.
CONCLUSION : Depth of grain transformation remained within 1-4 µm from the surface.
CONCLUSION : Descriptive data are presented for this general population sample of older men and women.
CONCLUSION : Despite a low incidence of prostate cancer in Tianjin , it is increasing at a fast rate.
CONCLUSION : Despite being safe and effective , low-dose ISO was not superior to @percent@ RA for advanced photoaging treatment.
CONCLUSION : Despite its importance , little attention has been given to the concept of frailty in family medicine.
CONCLUSION : Despite their willingness to be involved in a shared decision-making process , older residents and their families still have little experience with ACP.
CONCLUSION : Despite the telephone screening to enrollment ratio of @number@ to @number@ we met the recruitment goals for each trial.
CONCLUSION : Despite the well-known relative increased procedural risks , advanced age is not a contraindication for advanced endoscopic interventions.
CONCLUSION : Determination of bone age with MRI is feasible and shows good interobserver reproducibility.
CONCLUSION : DHA , alone or combined with EPA , contributes to improved memory function in older adults with mild memory complaints.
CONCLUSION : Diabetes and diabetic bladder disfunction will have a great impact on quality of life due to an aging population.
CONCLUSION : Diabetes may predispose to Achilles tendinopathy and particularly to Achilles enthesopathy.
CONCLUSION : Diabetic patients had higher CAC scores than nondiabetic patients , but the difference disappeared when clinical characteristics were taken into account.
CONCLUSION : Diagnoses at 24-months , appear to be reliable and stable.
CONCLUSION : Diagnosing and treating active tuberculosis among elderly people is difficult because of nonspecific and thus confusing findings due to other diseases or aging.
CONCLUSION : diagnostic accuracy for the identification of infection was comparable among tympanal and rectal thermometry and lower for temporal artery thermometry.
CONCLUSION : Diagnostic laparoscopy can be useful in elderly patient , since these patients may benefit from a more conservative surgical strategy.
CONCLUSION : Dietary AGEs appear to be important risk factors for AD.
CONCLUSION : Dietary intake of B-vitamins from food and supplemental sources appears unrelated to incidence of dementia and AD.
CONCLUSION : Dietary intake of methyl-donor micronutrients was not associated with measures of DNA methylation in our sample.
CONCLUSION : Differences exist between types of caregivers that explain variability in quality of life , depressive symptoms and perseverance time.
CONCLUSION : Differences in gait velocity persist between African Americans and Caucasians despite adjusting for many confounders.
CONCLUSION : Differences in long-term care residents ' self-care disability are largely explained by prevalent geriatric syndromes.
CONCLUSION : Differences in personality and illness explained both caring burden and mental health among caregivers.
CONCLUSION : Differences in their psychometric attributes , and discrepancy between them , were found for QoL-ADp and QoL-ADc.
CONCLUSION : Differences were found in disability , morbidity , and disease patterns according to living area.
CONCLUSION : Different aspects of people's social networks may help sustain levels of subjective well-being in older age.
CONCLUSION : Different biological processes were associated with prognosis and chemotherapy response in ER-positive and ER-negative breast cancers.
CONCLUSION : Different disease trajectories found among IDS-TILDA participants raise concerns.
CONCLUSION : Different health promotion strategies to target these populations should be accordingly developed.
CONCLUSION : Different methods of measuring and adjusting for comorbidity are not equivalent , and dementia amplifies the discrepancies.
CONCLUSION : Different optimal strength measurements were identified for different age groups.
CONCLUSION : Different physiological mechanisms contribute to the loss of lower extremity muscle power in healthy older and mobility-limited older adults.
CONCLUSION : Different ways of measuring unawareness are differentially associated with influencing factors.
CONCLUSION : Difficulties with noise exclusion failed to explain the sex differences found.
CONCLUSION : Disagreement about ACP participation was common.
CONCLUSION : Discontinuing warfarin after a diagnosis of dementia is associated with a significant increase in stroke and mortality.
CONCLUSION : DISH is associated with greater Cobb angle of kyphosis , especially when present in the thoracic spine alone.
CONCLUSION : Disinfectant use was more common among nurses working in smaller hospitals , possibly because they perform more diverse tasks.
CONCLUSION : Distinct nutritional risk trajectories were found for older men over a four year period.
CONCLUSION : DKK-1 serum levels were reduced in breast cancer patients receiving an adjuvant therapy with tamoxifen , possibly contributing to its bone-protective properties.
CONCLUSION : DL may be helpful to study central auditory dysfunction in aging.
CONCLUSION : driving anxiety and fear may be a significant problem for some young older adults that is likely to affect their independence and mobility.
CONCLUSION : DSM-5 NCD criteria can be operationalized in a psychometric algorithm in a population setting.
CONCLUSION : DTI parameters in both WML and NAWM correlate with cognitive performance , independent of SVD.
CONCLUSION : Dural puncture is inevitable for CEB applied at the S2 level.
CONCLUSION : During PVO , the clinical and radiological findings are similar in older patients.
CONCLUSION : During skeletal maturation , age and gender do not affect the osseous morphology or congruency of the patellofemoral joint.
CONCLUSION : During the first year following discharge , postoperative recovery of patients after hip fracture was associated with their family caregivers ' mental health.
CONCLUSION : DWI does not reveal probable parenchymal alterations in reflux nephropathy.
CONCLUSION : DWI with ADC maps can not be considered markers for placental aging because they are affected by perfusional and circulatory motion.
CONCLUSION : Dynamic FC exhibited differences from static FC in EH and YH , mainly in regions involved in cognitive control and the DMN.
CONCLUSION : Dysregulated psychoendocrinological interactions might affect oral mucosal MUC1 expression and severity of oral burning sensation in post-menopausal BMS patients.
CONCLUSION : Each Advanced Cognitive Training for Independent and Vital Elderly cognitive intervention resulted in less decline in self-reported IADL compared with the control group.
CONCLUSION : Each set of criteria displayed relevance through mutual agreement of known high-risk medication classes in older people.
CONCLUSION : Early application of sunscreen after ablative fractional skin resurfacing has increased the incidence of sensitization potential of sunscreen.
CONCLUSION : Early but not late components of the mouse complement system show an age-dependent increase in expression.
CONCLUSION : Early consumption of alcohol may increase the odds of having periodontitis @number@ years later.
CONCLUSION : Early-follicular phase antimüllerian hormone appears to be associated with natural fertility in the general population.
CONCLUSION : Early mobilization was possible in the majority of cases , which may be a prerequisite for satisfying functional results.
CONCLUSION : Early surgical management for FMEC is advisable to avoid deleterious effects on facial growth.
CONCLUSION : Eating together is associated with subjective health and food intake.
CONCLUSION : ECG abnormalities are more common among elderly Chagas disease patients and strongly predict adverse outcomes.
CONCLUSION : Economic pressures are increasing the expectation that patients who undergo successful OLT will return to work.
CONCLUSION : Edentulousness is still common among older service housing residents.
CONCLUSION : Educational strategies can influence the attitudes and empathy of students , leading to different outcomes.
CONCLUSION : Education influenced sentence listening comprehension on elderly.
CONCLUSION : Education significantly impacted diet quality in the HANDLS sample , but race cannot be discounted.
CONCLUSION : Effects of intervention studies should be carefully interpreted regarding the absolute reproducibility.
CONCLUSION : EHT has a significant occurrence in elderly patients.
CONCLUSION : Either walking speed or grip strength measurement may be suitable for frailty screening in primary care or population health survey.
CONCLUSION : Elder abuse is associated with an increased risk for metabolic syndromes.
CONCLUSION : Elderly adults with normal cognition at baseline who used statins had a slower rate of annual worsening in CDR-SOB than nonusers.
CONCLUSION : - Elderly affected by stroke that present dysphagia has low scores in quality of life related to swallowing.
CONCLUSION : Elderly Asians have a high burden of SVD which was associated with cognitive dysfunction.
CONCLUSION : Elderly individuals with SCI have distinct characteristics and clinical factors related to gender and age.
CONCLUSION : Elderly lung cancer patients could be benefit from surgery and adjuvant chemotherapy while early stage.
CONCLUSION : Elderly participants showed a more asymmetrical and irregular gait than young participants.
CONCLUSION : Elderly patients are at greater risk for developing CI-AKI.
CONCLUSION : Elderly patients expressed a different pattern of MP in stable conditions , with a different response to sepsis in procoagulant activity modification.
CONCLUSION : Elderly patients were likely to suffer both falls and a further traumatic condition.
CONCLUSION : Elderly patients with cancer experience a higher prevalence of geriatric syndromes than those without cancer.
CONCLUSION : Elderly patients with dementia enrolled for suspected syncope and unexplained falls have high comorbidity and disability.
CONCLUSION : Elderly patients with OSAHS demonstrated cardiac structural changes and their left ventricular diastolic and systolic functions were significantly diminished.
CONCLUSION : Elderly population with OA is at an elevated risk of falling , which increases with progressing age , pain , and muscle weakness.
CONCLUSION : Elder self-neglect was associated with increased rates of emergency department utilization in this community population.
CONCLUSION : Elders who reported that cognitive problems impacted their daily functioning reported the greatest health and mental health problems.
CONCLUSION : Elevated leptin level is predictive of CV mortality only in men.
CONCLUSION : elevated neopterin levels had IL-6-independent association with prevalent frailty , suggesting potential monocyte / macrophage-mediated immune activation in the frail elderly.
CONCLUSION : Elevated plasma Cp levels were significantly associated with obesity , which may be suggested to be a marker of obesity.
CONCLUSION : Elevated plasma Hcy level may affect real-space navigation performance above and beyond vascular brain changes.
CONCLUSION : Elevated stroke risk at midlife is associated with accelerated cognitive decline over @number@ years.
Conclusion : EM and its subtypes were significantly associated with SI ; some associations varied by definitions and subtypes.
CONCLUSION : Emergency department admission after trauma in patients aged ≥65 years is common after low-energy falls , and most injuries occur to the extremities.
CONCLUSION : Emergency department nurses ' attitudes towards and knowledge about ageing processes may affect therapeutic interactions between nurses and their older patients.
CONCLUSION : Emergent surgical repair of intrathoracic stomach was associated with markedly higher mortality and morbidity than elective repair.
CONCLUSION : Emervel Classic provides similar efficacy and better overall local tolerability compared with Restylane @number@ months after treatment of moderate nasolabial folds.
CONCLUSION : Emmetropia was not the predominant outcome for refractive development in children.
CONCLUSION : Emotion-focused , patient-centered interventions like PIPAC hold promise for advancing treatment options in the early and mild stages of dementia.
CONCLUSION : Enamel grinding , aging method , and type of enamel surface significantly influenced the SBS.
CONCLUSION : Energy drinks used in this study had staining effect on the tested composite resin materials.
CONCLUSION : Engagement in spiritual activity may benefit cognitive function in old age.
CONCLUSION : Engaging community members in design and implementation of community-based programs and trials enhances cultural appropriateness and congruence with the community context.
CONCLUSION : Engaging elderly people living in the community in VBF training was found to be effective and could improve their balance ability.
CONCLUSION : Enlarged but relatively stable SEP amplitudes had a consistency with so-called self-limited clinical course in Japanese ULD.
CONCLUSION : Entrance-related environmental barriers may hinder community-dwelling older people to move out-of-home daily especially when their functional capacity is compromised.
CONCLUSION : Epicardial fat volume and the baseline extent as well as progression of coronary atherosclerosis-measured by the calcium score-are significantly correlated.
CONCLUSION : Epidemiological surveys may substantially underestimate the levels of frailty among older people in the general population.
CONCLUSION : Eruca sativa Mill. presents antiplatelet and antithrombotic activity.
CONCLUSION : Especially tryptase , but probably also chymase , may have an influence on the skin of smokers , such as wrinkling and aging.
CONCLUSION : ESs had fewer \ "classical \ " risk factors and were in better health than their contemporaneous controls.
CONCLUSION : Estrogens and androstanediols seem to play a role in BPH development.
CONCLUSION : Even a minor weight loss of ≥5% or > 3 kg were significantly associated with increased risk of mortality.
CONCLUSION : Even moderate or severely demented residents could do exercises in five-person groups under the supervision of a physiotherapist.
CONCLUSION : Evidence for association between subjective cognition and brain amyloid-β deposition in healthy older adults is demonstrable but measure-specific.
CONCLUSION : Evidence of beneficial effects of multi-domain compared to mono-domain interventions is limited but increasing.
CONCLUSION : Evidence of reduced mobility was evident during GARU admission amongst older people assessed as malnourished.
CONCLUSION : Evidence on risk factors for ARM from epidemiological studies is still very limited.
CONCLUSION : EVOO illustrated significant anti-osteoporosis , antioxidant , anti-inflammatory , and anticancer properties in vivo.
CONCLUSION : Except for psychological complaints , workers with a longstanding health condition generally perform well while being at work.
CONCLUSION : Excluding the tumor grade and tumor size , both groups had similar histopathological features.
CONCLUSION : Exercise may affect not only risk for AD but also subsequent disease duration : more PA is associated with prolonged survival in AD.
CONCLUSION : Exercise training , even of short duration and light to moderate intensity , can increase muscle strength while decreasing fall risk in nonagenarians.
CONCLUSION : Exhaustion is common in old age but is dynamic , even in those with a history of cancer and congestive heart failure.
CONCLUSION : Existing nightstands do not meet the needs of current users.
CONCLUSION : Expanded bandwidth and bimodal presentation can improve speech perceptibility in difficult listening conditions but may not always improve working memory performance.
CONCLUSION : Explicit learning , but not implicit learning , declines in older adults.
CONCLUSION : Exposure to FRIDs and other measures of high-risk medication exposures is common in older people admitted with falls , especially the frail.
CONCLUSION : Facial pigmentation may be a useful biomarker for carotid atherosclerosis in Japanese women.
CONCLUSION : Factors likely to improve end-of-life care include advance care planning , earlier recognition of short prognosis and staff education.
CONCLUSION : Factors measured earlier in adulthood were associated with grip strength decline in late midlife and old adulthood.
CONCLUSION : Factors related to adherence with exercise in the elderly are multifactorial.
CONCLUSION : Fall risk awareness is low in older adults.
CONCLUSION : Fat mass has a greater influence on serum 25 ( OH ) D than dietary vitamin D intake.
CONCLUSION : FC during worry induction and reappraisal points toward abnormalities in both worry generation and worry reappraisal.
CONCLUSION : FCR improved metabolic parameters and DNA damage in healthy older adult men.
CONCLUSION : Fear of recurrence ( mostly low levels ) is highly prevalent among long-term breast cancer survivors and can negatively affect QoL and well-being.
CONCLUSION : Fifty percent of adults with advanced cancer , regardless of age , will experience a fall associated with high risk of physical injury.
CONCLUSION : Findings from this study confirm the large amount of interindividual variability in the symptom experience of oncology patients.
CONCLUSION : Findings from this study provides supportive evidence for HCC as a moderator to ameliorate burnout and facilitate engagement among elderly service workers.
CONCLUSION : Findings from this study support the effectiveness of evidence-based programs for reducing falls-related risks in older women.
CONCLUSION : Findings provide support for accumulating evidence on the adverse mental health effects of discrimination among older African Americans.
CONCLUSION : Findings show that the concept ' post-traumatic growth ' is an important factor influencing successful aging in middle-aged women.
CONCLUSION : Findings show that the Vital Aging program in face-to-face and combined versions encourages active aging in Mexican older persons.
Conclusion : Findings suggest a robust relationship between self-reported discrimination and depressive symptoms in older Chinese Americans.
CONCLUSION : Findings suggest strong measurement characteristics for the GSIS with community-residing older adults , including impressive consistency over time.
CONCLUSION : Findings suggest that individualized social activities are a promising treatment for cognitively impaired geriatric inpatients.
CONCLUSION : Findings suggest that multi-faceted experiences impact participation in activity following TJR.
CONCLUSION : Findings suggest that non-aerobic training should be further explored as a beneficial intervention for older adults suffering from MCI.
CONCLUSION : Findings suggest that self-regulation may protect against risk of CHD in older men.
CONCLUSION : Findings suggest that while African-American custodial grandmothers find caregiving rewarding , they face unique challenges in contemplating and developing future plans.
CONCLUSION : Findings support raloxifene for reducing vertebral fracture risk by improving BMD and reducing bone turnover in postmenopausal Japanese women with osteoporosis or osteopenia.
CONCLUSION : First-line gefitinib could be a preferable standard treatment in elderly patients with advanced NSCLC harboring sensitive EGFR mutations.
CONCLUSION : Fluoride varnish applied immediately before pit and fissure sealant placement negatively affected the shear bond strength of the sealant.
CONCLUSION : FMS , especially with severe progression and a high degree of chronification , demands a multidisciplinary approach.
CONCLUSION : Following a VT task , older adults still display use-dependent plasticity.
CONCLUSION : Following onset of gout , patients in Ontario incur significantly greater healthcare costs and resource use compared to matched gout-free patients.
CONCLUSION : Food intolerance was associated with age , sex and body mass index.
CONCLUSION : Foot function was related to hallux valgus and overlapping toes , especially among the obese.
CONCLUSION : For elderly patients aged @number@ years or over , caution should be exercised in selecting PD for patients with pancreatic cancer.
CONCLUSION : For evaluating and treating IVD degeneration , MRI is a good and non-invasive diagnostic tool to determine the severity of degeneration.
CONCLUSION : For the first time , the trajectories of life quality in the third age are drawn and improvement across cohorts is demonstrated.
CONCLUSION : For those who desire it , an internal job change may allow for a recalibration of cynicism and increase employee engagement.
CONCLUSION : For treatment of osteoporosis , ALP is an acceptable alternative to BAP.
CONCLUSION : For zirconia crowns , retention seems to be dependent on cement type rather than surface treatment.
CONCLUSION : Four out of @number@ people reported being very happy , and five out of @number@ were fairly happy.
CONCLUSION : Fourteen percent of women participating were not able to perform active contraction of the PFM.
CONCLUSION : FOXO1 may influence the clinical response to AChEIs in AD patients.
CONCLUSION : FP and FI predict postoperative outcomes after major elective orthopedic surgery and should be considered for preoperative risk stratification.
CONCLUSION : FPC should be standardized according to the characteristics of the population in order to improve its predictive ability.
CONCLUSION : FPKc inhibited S180 tumor cells growth and prolonged the lifespan of mice.
CONCLUSION : Fractional bipolar RF and fractional erbium-doped glass have similar effectiveness for the treatment of atrophic acne scars.
CONCLUSION : Fractional photothermolysis with @number@ nm Erbium fiber Laser is one of the effective treatments for facial wrinkle.
CONCLUSION : Fractions of deciduous root resorption can help to predict age.
CONCLUSION : Fracture incidence increased with age among HIV + and HIV- men but was higher among HIV + men.
CONCLUSION : Fractures of the hip are becoming more common and more complex in an aging , increasingly frail population.
CONCLUSION : Frailty and comorbidity are meaningful and complementary associated with increased hospital healthcare resources use , and related costs.
CONCLUSION : Frailty and pre-frailty appear to be associated with higher OS and possibly lower anti-oxidant parameters.
CONCLUSION : Frailty in older adults is a syndrome corresponding to a vulnerability to a stressor.
CONCLUSION : Frailty is associated with an increase in the rate of mortality , hospitalizations and dependence in basic activities of daily life.
CONCLUSION : Frailty is independently associated with the FoF syndrome in older faller subjects.
CONCLUSION : Frailty is strongly associated with cognitive impairment and clinically diagnosed dementia among persons aged @number@ and older.
CONCLUSION : Frailty was associated with Alzheimer's disease and dementia over a seven years period.
CONCLUSION : Frequent falling was associated with at-fault MVC involvement of older drivers , especially whites.
CONCLUSION : Frequent negative social interactions may be a risk factor for mild cognitive impairment and cognitive decline in old age.
CONCLUSION : From a public health point of view , left-handed men may be regarded as a relatively vulnerable population category concerning mental health.
CONCLUSION : From frailty to hyperactivity there are different falls and fallers profiles.
CONCLUSION : From one perspective , these results show that older adults do perceive postural constraints in light of their own physical capabilities.
CONCLUSION : From the perspective of the UK NHS , MRCP was the most cost-effective test in the diagnosis of CBD stones.
CONCLUSION : FTS associates with many of the factors linked to frailty and has a similar predictive capacity to that provided by the classical instruments.
CONCLUSION : Full correction of the NLFs with HA filler significantly and positively influences the first impression an individual projects.
CONCLUSION : Full-scale MMSE scores can be reasonably accurately derived from an 11-item abbreviated version.
CONCLUSION : Functional ability is significantly reduced at @number@ year after an initial presentation to the ED with a fall.
Conclusion : Functional impairment and decline are common in middle age , as are transitions from impairment to independence and back again.
CONCLUSION : Functional networks underlying facial emotion perception are considerably changed in left and right MTLE.
CONCLUSION : Further research into interventions using new technologies to reduce loneliness in older people is recommended.
CONCLUSION : Further research is needed to investigate whether driving anxiety contributes to premature driving cessation.
CONCLUSION : Further research is needed to understand the negative association between NCMS coverage and outpatient care utilization.
CONCLUSION : Further studies examining the relationship between duration and extent of exposure to HIV viraemia in relation to developing abnormal endocrine function are warranted.
CONCLUSION : Further studies including control groups and accounting for potential confounders are needed for a sound assessment of the effectiveness of this technique.
CONCLUSION : Further studies should evaluate the lower tendency of elderly people with religious affiliations to seek treatment for mental health problems.
CONCLUSION : Further studies will warrant possible applications of curcuminoids as therapeutic BACE-1 blockers.
CONCLUSION : Future research is needed to assess the time to benefit of treatments and to develop guidelines for medication discontinuation in advanced ALS.
CONCLUSION : Future research should aim to further understand the role of soda consumption on risk for hypertension in this population.
CONCLUSION : Future research should focus on improving quantitative measurement and mechanistic understanding of impaired activation with aging.
CONCLUSION : Future studies need to identify the rare genetic variants underlying the linkage peak in chromosome @number@ for FEV1.
CONCLUSION : Gabapentin and pregabalin are the two anticonvulsants which have been shown to have some benefit in reducing neuropathic pain.
CONCLUSION : Gait characteristics in people with frailty are insufficiently analyzed in the literature and represent a major area for innovation.
CONCLUSION : Gait parameters in multiple walking conditions adjusted for age , gender and leg length showed a significant association with cognitive impairment.
CONCLUSION : Gastric vascular dysfunction and senescence may be associated with increased oxidative stress and decreased antioxidative defense in the aging process.
CONCLUSION : Gastroscopic balloon dilatation is an effective method in the treatment of membranous duodenal stenosis in children.
CONCLUSION : Gender and histology should be taken into account in preoperative evaluation of indication for lung cancer in octogenarians.
CONCLUSION : Gender has a prominent effect on RF's sensorial responses.
CONCLUSION : Geriatric assessment performed online using a nurse-administered structured CGA system was no less reliable than conventional assessment in making clinical triage decisions.
CONCLUSION : Geriatric psychiatry patients are at a greater risk for clinically important decreases of renal function than similarly aged controls.
CONCLUSION : Geriatric syndromes and functional impairment afflicted majority of old people who attended the Landspitali ED.
CONCLUSION : Gerontome can be accessed through web interfaces for querying and browsing.
CONCLUSION : GH receptor blocker administration in healthy humans resulted in a moderate decrease in serum IGF-I.
CONCLUSION : GI lesions commonly occur in Chinese BD patients.
CONCLUSION : Ginsenoside Rg1 has the effect of delaying and treating Sca-1 ( + ) HSC / HPC aging during the serial transplantation.
CONCLUSION : Given covariate balancing with both methods , attenuated program impacts in the young adult population indicated that one-to-one greedy matching introduced selection bias.
CONCLUSION : given these costs and improvements in life expectancy , an increasingly obese older population presents new challenges for healthcare delivery.
CONCLUSION : GKRS for BM results in a high rate of local control with an 11-month rate of @percent@.
CONCLUSION : GLP-1RA exenatide can inhibit human VSMCs calcification through NF-κB / RANKL signaling.
CONCLUSION : Good daily functioning of elderly patients significantly depended on their intellectual and mental efficiency.
CONCLUSION : Good - excellent volume enhancement was noted almost immediately after the HA injections , improving patient reported quality of life aspects.
CONCLUSION : GR antagonism can potentiate age-related sleep pattern alterations and further support the role of impaired GR signaling in age-related changes in sleep architecture.
CONCLUSION : GRASE-derived T2 maps are highly reproducible.
CONCLUSION : Gray matter loss occurs during aging with rates of atrophy even more severe than that observed during the course of AD.
CONCLUSION : Greater allocation of abdominal adipose tissue into the visceral compartment occurs in EA than AA women and in older than younger women.
CONCLUSION : Greater engagement in vigorous LTPA and exceeding the PA recommendation may have a protective effect against telomere shortening.
CONCLUSION : Greater frequency of cognitive activity is associated with better neurocognitive function in older persons with HIV , particularly older Blacks.
CONCLUSION : Greater life-space mobility at baseline was predictor of slower rates of cognitive decline over @number@ years in older Mexican Americans.
CONCLUSION : Greater neighborhood disadvantage was associated with greater risk of falls.
Conclusion : Greater PPWB was associated with more sexual behaviour in partnered , community-dwelling older adults.
CONCLUSION : Grief symptoms like those experienced by family caregivers are common among direct care workers after patient death.
CONCLUSION : Grip strength and strength per unit size declined with age.
CONCLUSION : Grip strength is associated with walking ability in hospitalized frail elderly.
CONCLUSION : Growth failure in early life has profound adverse consequences over the life course on human , social , and economic capital.
CONCLUSION : GSI predicts impaired physical function , cognitive dysfunction , significant weight loss , and mortality @number@ years later in older U.S. adults.
CONCLUSION : GSs alone are associated with functional impairment in older women ; the association is stronger in the presence of even one CMD.
CONCLUSION : GWG , physical activity and smoking status during pregnancy were significantly associated with obesity for the offspring at the age of @number@
CONCLUSION : HAART had a positive long-term effect on the progression to SILs.
CONCLUSION : Habitual tea consumption was associated with better HRQOL in older adults.
CONCLUSION : Half of obese Russian inhabitants are metabolically healthy.
CONCLUSION : Half of this geriatric population did not receive any anticoagulation despite a clear indication , regardless of their individual bleeding or stroke risks.
CONCLUSION : Half the participants were at high nutrition risk.
CONCLUSION : Handwritten spirals appear to have a single predominant axis in more ET than dystonia cases.
CONCLUSION : HARP is a poor predictor of quality of life.
CONCLUSION : Having multiple CMBs or concomitant CMBs and retinopathy is associated with a profile of vascular cognitive impairment.
CONCLUSION : Having over @number@ missing teeth was associated with severe cognitive impairment among Chinese older adults.
CONCLUSION : Hazelnut allergy in a birch-endemic region exhibits age-related sensitization profiles with distinct clinical outcomes that can be identified using CRD.
CONCLUSION : HBx induced ROS promoted Akt pathways via oxidized inactive PTEN.
CONCLUSION : HCT induces A375 programmed cell death by activating the caspase-dependent pathway and by p38 phosphorylation associated with HMGB1 reduction.
CONCLUSION : HCV may be a risk factor for patients with AH with a worse outcome at @number@ months.
CONCLUSION : HDL and the albumin / globulin ratio were potential indicators for individual somatic genomic aging.
CONCLUSION : Healthcare practitioners should adopt the provision of leisure education as a priority to facilitate leisure competence and reduce stress among older adults.
CONCLUSION : Health-care providers should routinely discuss falls prevention with older adults.
CONCLUSION : Health-related conditions that affect the oldest old vary by gender and ethnicity and entail careful evaluation and monitoring in the clinical setting.
CONCLUSION : Health-related QOL in older women with urinary incontinence was relatively low , while levels of stress and depression were high.
CONCLUSION : Health services face challenges as a result of changing population demographics and nursing shortages.
CONCLUSION : Healthy non-frail older adults require higher intensities of physical activity for continued improvement in frailty trajectories.
CONCLUSION : Heavy manual labor and diabetes mellitus in males and housekeeping ( females ) play major roles in the genesis of DLSS.
CONCLUSION : Height was found to be associated with anemia for rural Japanese men and drinking status is likely to affect those associations.
CONCLUSION : Helicobacter pylori induces internalization of EGFR via novel TAK1-p38-serine activation pathway which is independent of HB-EGF.
CONCLUSION : Herbalife NC membership was positively associated with perceived health and measured cardiometabolic benefits.
CONCLUSION : Heshouwuyin exerts an important role in controlling testosterone secretion and sperm function.
CONCLUSION : Heterogeneity in the neuroinflammatory state of the early AD brain.
CONCLUSION : HF appeared to have the same clinical profile over a 3-year period.
CONCLUSION : High accumulations of these minerals may increase oxidative stress in Mongolian people , and induce Parkinsonism and arthritis through the high oxidative stress.
Conclusion High biomechanical exposure and job strain in midlife were strongly associated with the severity of disability in later life.
CONCLUSION : High CM-specific IgE levels predict the persistence of CMA.
CONCLUSION : High CRP levels at baseline are related to elevated depressive symptomatology at follow-up due to clinical factors.
CONCLUSION : High-dose estrogen-treated tall women are at risk of subfertility in later life.
CONCLUSION : High doses of SUAs inhibited the functionality of ABCA1 / SR-BI , but not ABCG1.
CONCLUSION : High E2 level is an independent predictor of incident dementia , particularly in postmenopausal women with diabetes.
CONCLUSION : Higher aMED is associated with better QOL and decreased pain , disability , and depressive symptoms.
CONCLUSION : Higher androgenicity was positively associated with symptoms of anxiety and depression in postmenopausal women.
CONCLUSION : Higher BP is associated with better cognitive function in the oldest old and in those with impaired functional status.
CONCLUSION : Higher calibrated protein intake is associated with better physical function and performance and slower rates of decline in postmenopausal women.
CONCLUSION : Higher cardiovascular fitness of CVD patients is associated with superior cognition - predominantly in attention and executive functioning.
CONCLUSION : Higher education level and cognitive ability measured at age @number@ or @number@ were associated with having more teeth at age @number@
CONCLUSION : Higher midlife BMI is related to higher risk of dementia and AD , independently of obesity-related risk factors and co-morbidities.
CONCLUSION : Higher paracetamol concentrations observed in frail older patients after @number@ days of therapeutic paracetamol do not necessarily indicate an increased risk of hepatotoxicity.
CONCLUSION : Higher PSS scores are associated with greater pain intensity and interference.
CONCLUSION : Higher SL was positively associated with phenotype frailty and the FI.
CONCLUSION : Higher TNF-α and IL-6 levels in schizophrenia patients were associated with depression , physical comorbidity , and mental well-being.
CONCLUSION : Higher visit-to-visit variability in blood pressure independent of average blood pressure was associated with impaired cognitive function in old age.
CONCLUSION : high morale is independently associated with increased survival among very old people.
CONCLUSION : High preoperative and POD2 CRP were independently associated with delirium incidence , duration , and feature severity.
CONCLUSION : Hip strength is a more important indicator of physical functioning than lean mass.
CONCLUSION : HIV and HCV infections contribute to chronic inflammation ; however , reduced CRP possibly occurs through HCV-mediated mechanisms.
CONCLUSION : HIV infection was independently associated with reduced physical performance.
CONCLUSION : Holding an external load of @percent@ of body mass increased postural instability of both younger and older adults with and without CLBP.
CONCLUSION : home and centre physical assessments are required to avoid systematically over-representing healthier and wealthier respondents.
CONCLUSION : home-dwelling hip fracture patients can benefit from an extended supervised strength-training programme in a rehabilitation setting.
CONCLUSION : Hong Kong is facing increasing healthcare burden caused by the rapid increase in demand for inpatient services due to ageing.
CONCLUSION : Hospice use at the end of life may not be associated with lower public expenditures in older dually eligible AL residents.
CONCLUSION : Hospital admissions due to falls are most frequent within the first month after fast-track THA and TKA.
CONCLUSION : Hospitalization and being female appeared to be the most significant risk factors for disability in urban older adults in India.
CONCLUSION : Hospitalization due to an ADR is a common occurrence in this older population.
CONCLUSION : Hospitalization is associated with significant changes in body composition and strength in older persons.
CONCLUSION : Hospitalization may be a critical period for preventing future institutionalization among elderly patients.
CONCLUSION : Hospitalized older adults prefer to turn to paid caregivers rather than to their families.
CONCLUSION : H. pylori-positive elderly patients should undergo eradication therapy.
Conclusion : HR-pQCT measurement of cortical area and mass might add clinically useful information for the evaluation of fracture risk.
CONCLUSION : HRQOL and state of fatigue in breast cancer patients treated with radiotherapy depended upon their age.
CONCLUSION : HRQOL dimensions are not all linearly associated with increasing cognitive impairment in NH patients.
CONCLUSION : HRV in hemodialysis patients is lower than in the general population.
CONCLUSION : Human power decline in Masters athletes was analyzed , adopting a coherent approach based on an extended database.
CONCLUSION : Hypermethylation of IFN and ICAM- @date@ play important roles in early carcinogenesis , particularly that of prostate cancer.
CONCLUSION : Hyperopia is the most common refractive error and its prevalence and seems to increase among the aging population who visited the clinics.
CONCLUSION : Hypertension prevalence increased rapidly between the years surveyed.
CONCLUSION : Hypertension remarkably impacted the active life expectancy on senior citizens living in Beijing , especially for elderly.
CONCLUSION : Hypertension was highly prevalent among the total sample.
CONCLUSION : Hypertensive patients with orthostatic hypertension or hypotension may have an elevated risk of developing target organ damage.
CONCLUSION : Hypoandrogenism is common among infertile men , and routine hormonal evaluation may identify hypoandrogenism in many infertile men with otherwise normal semen analysis.
CONCLUSION : Hypoglycemia risk in nursing home residents is observed in all categories of glycemic control.
CONCLUSION : Hypogonadism is a prevalent disorder among Jordanian diabetic population.
CONCLUSION : Hypogonadism is common , particularly in aging men.
CONCLUSION : Hyponatremia was more common in females and they seemed to better tolerate it than their male counterparts.
CONCLUSION : ICA PI is comparable with femPWV in its association with cardiovascular disease.
CONCLUSION : Identification of deficits is a prerequisite for specific therapy.
CONCLUSION : Identification of modifiable risk factors would improve the possibilities of preventing the progression of AMD.
CONCLUSION : IGF2R is related to cell replicative senescence and its gene expression is regulated by histone modification of H3.
CONCLUSION : IHC using the VE1 antibody is a specific and sensitive method for the detection of the BRAF ( V600E ) mutation in PTC.
CONCLUSION : IL1RN polymorphisms reproducibly contribute to disease severity in knee OA and may be useful biomarkers for patient selection in disease-modifying OA drug trials.
CONCLUSION : Imbalanced vitamin intake was observed in the middle-aged and elderly Iranian population.
CONCLUSION : Immediate dentin sealing improves adhesion , and thereby the fracture strength of inlays made of lithium disilicate but not that multiphase resin composite.
CONCLUSION : Immunological abnormalities are frequent in this frail population and lymphopenia , in particular , could constitute a reinforcing factor of fragility.
CONCLUSION : Immunosenescence appeared to be pronounced in patients with breast cancer , with senescent CD8 + T-cells playing a role.
CONCLUSION : Implantation of @number@ testosterone pellets ( @number@ mg ) was well tolerated and provided adequate and sustained serum testosterone concentrations.
CONCLUSION : Implementation educational intervention based on precedes-proceed model can improve quality of life in elders.
CONCLUSION : Implementation of a 3-mo Lifestyle Redesign-inspired program within a health care system was feasible.
CONCLUSION : Implementation of TCDS significantly improved @number@ of @number@ health promotion skills and behaviors of Spanish-speaking older adults in South Florida.
CONCLUSION : Implications revealed that post-stroke interventions need a more occupation-focussed approach , including return to leisure at an earlier stage of stroke rehabilitation.
Conclusion / implications : Time spent sedentary ranges from @number@.3-9.4 hr per waking day in older adults.
CONCLUSION : Implications were discussed in employee selection and employee well-being , particularly in the customer service context.
CONCLUSION : Improved cardiorespiratory fitness , strength , balance and mobility provide preliminary evidence of the trainability of individuals with both DS and stroke.
CONCLUSION : Improved diabetes control in the elderly following existing guidelines through a telemedicine intervention was associated with less global cognitive decline.
CONCLUSION : Improvement of epilepsy or sleep disorders should not disregard the clinical suspicion of AS in adolescent or adult patients with suggestive features.
CONCLUSION : Improving family planning interventions in low and middle income countries appears to be cost-effective.
CONCLUSION : Impulsive traits and history of unplanned suicide attempts partly explain the heterogeneity in neural responses to angry faces in depressed elderly.
CONCLUSION : In addition to socio-demographic factors , cumulative effects of multiple geriatric syndromes might affect life satisfaction in the older adults.
CONCLUSION : In a dedicated geriatric care pathway , DP and CSND undergoing hip surgery have the same 6-month mortality and walking ability as NDP.
CONCLUSION : Inadequate vitamin D status is highly prevalent among Australian older men and is associated with specific lifestyle factors.
CONCLUSION : In adults , penetrating , moderate , and severe TBIs are associated with cognitive deficits @number@ months or longer postinjury.
CONCLUSION : • In aging males , androgen deficiency symptoms were reported at normal levels of testosterone , but age was an important confounder.
CONCLUSION : In an interrupted trial with amnestic MCI subjects the combination of galantamine plus memantine were generally well tolerated.
CONCLUSION : In a population free of clinical thyroid disease , TSH and FT4 values rise over the years.
CONCLUSION : in a population setting , cut-off scores from the CAMCOG memory subscales predicted dementia with reasonable accuracy.
CONCLUSION : In BASE-II low skeletal muscle mass was much more frequent than reduced grip strength or poor function.
CONCLUSION : In Basse-Normandie , the surgical activity in gynecology-obstetrics will moderately increase in the next @number@ years.
CONCLUSION : In children , CT increases with age and is inversely correlated to axial length.
CONCLUSION : Incidence of influenza-like illness for the elderly people in the community decreased by administered PenV23 ahd InfV-B vaccine.
CONCLUSION : Incident dementia in Yoruba Nigerians is higher than previously reported.
CONCLUSION : Including familiar protein enriched foods and drinks in the menu helped to meet protein recommendations in institutionalized elderly.
CONCLUSION : IncobotulinumtoxinA is an effective and well-tolerated treatment for platysmal bands , with a rapid onset and long duration of effect.
CONCLUSION : IncobotulinumtoxinA is equally as effective as onabotulinumtoxinA in the treatment of glabellar frown lines.
CONCLUSION : IncobotulinumtoxinA rapidly improved wrinkle severity , and improvements were maintained for up to @number@ days.
CONCLUSION : In community-dwelling older adults , CKD is associated with IADL and BADL decline.
CONCLUSION : In comprising the lacrimal sac fossa , the maxillary bone accounted for a bigger proportion than the lacrimal bone.
CONCLUSION : In conclusion , 23-HTA protects against and attenuates UVA-induced oxidative stress in NHDFs likely via the nuclear factor erythroid-derived 2-like @number@ signaling pathway.
CONCLUSION : In conclusion , regional differences in CBF and changes with postmenstrual age could be detected with ASL in neonates.
CONCLUSION : Increased ankle co-activation in the anterior-posterior plane and inverted ankle muscle coordination pattern merely occurred during single-leg stance.
CONCLUSION : Increased GLB1 is a valuable marker in formalin-fixed paraffin-embedded ( FFPE ) tissues for the senescence-like phenotype and associates with improved cancer outcomes.
CONCLUSION : Increased IMAT in the proximal hip muscles , particularly the hip abductors , was associated with increased gait variability and poorer balance.
CONCLUSION : Increased IMT and calcifications at US are common findings in hemodialysis patients.
CONCLUSION : Increased time in Stage N1 and less time in Stage R are associated with worsening cognitive performance in older men over time.
CONCLUSION : Increases in capecitabine Cmax and AUC was observed in patients ≥70 years when compared with younger patients who were > 60 years.
CONCLUSION : Increasing age after @number@ is associated with worsening OS and DSS in OPSCC.
CONCLUSION : Increasing Age and anticholinergic medications induce a dry mouth.
CONCLUSION : Increasing age correlated positively with coexisting arterial aneurysms.
CONCLUSION : Increasing age , female sex and low education were associated with higher CI in LAC reflecting patterns found in other countries.
CONCLUSION : Increasing age is associated with the disappearance of abdominal pain in the community.
CONCLUSION : Increasing cardiovascular drug utilization may pose a substantial burden on future health care resources.
CONCLUSION : Increasing mFI scores are associated with worsening outcomes for patients undergoing RARP.
CONCLUSION : Increasing multimorbidity in community-dwelling women is associated with an increase in RMR independently of body composition and age.
CONCLUSION : Increasing secondary health complications and a need to save strength / energy influenced participation in activities.
CONCLUSION : Individual differences in trajectories of cognitive aging are associated with subsequent risk of hospitalization.
CONCLUSION : Individuals who endorse depressive symptoms during screening are likely to have clinically significant depression and need mental health treatment.
CONCLUSION : Individuals who were married and those who were very satisfied with life are protected against the risk of developing MCI and dementia.
CONCLUSION : Individuals with dementia live and frequently die in community settings.
CONCLUSION : Individuals with sarcopenia are not only more likely to have single but also to have dual impairment in cognitive and physical function.
CONCLUSION : In elderly men , low plasma testosterone is associated with elevated carotid intima-media thickness only in those with low-grade inflammation.
CONCLUSION : In elderly patients , all SSAs were located in the proximal colon.
CONCLUSION : In elderly patients over @number@ years of age , sex influences the prognosis after percutaneous coronary intervention for coronary heart disease.
CONCLUSION : Inflammation , dyslipidemia and altered sex-steroid milieu mutually concur in determining BPH / LUTS.
CONCLUSION : Inflammatory biomarkers are potentially feasible for systematic assessment of vulnerability.
CONCLUSION : Inflammatory burden is associated with prevalent PAD , an association similar to aging @number@ years.
CONCLUSION : Inflammatory marker levels tracked over the long term into older age with within-person increases were observed.
CONCLUSION : Influenza vaccination was effective against hospitalization and mortality among the frail elderly.
CONCLUSION : Informant-based , single-item screening questions show promise for detecting cognitive impairment.
CONCLUSION : Informant memory complaint questions were better than participant complaints in predicting cognitive and functional decline as well as diagnoses over @number@ years.
CONCLUSION : Informatics can advance health care for older adults and support a holistic assessment of older adults ' wellness.
CONCLUSION : Information on working hours may improve risk prediction of CHD on the basis of the Framingham risk score in low-risk , working populations.
CONCLUSION : In France , as in other western countries , women aged @number@ years and over are not managed according to guidelines.
CONCLUSION : In general , the received values were concordant to results of other studies.
CONCLUSION : In geriatric outpatients , polypharmacy rather than number of comorbidities was associated with fall risk.
CONCLUSION : In haemodialysis patients , long-term treatment with PPIs , especially in the presence of warfarin treatment , is associated with vascular calcifications.
CONCLUSION : In healthy elderly individuals , BRS decrease was associated with a weak but significant decrease in memory function.
CONCLUSION : In healthy relatively high-functioning women and men , kyphosis severity was not associated with subsequent physical function.
CONCLUSION : In-home CGA has a modest positive effect on functional status and quality of life.
CONCLUSION : In hypertensive perimenopausal women components of MS are stronger predictors of subclinical organ damage than MS itself.
CONCLUSION : In Japan , elderly dysphonic patients were prevalent and rapidly increasing in recent years.
CONCLUSION : Injury results in differences in innate immune function in the elderly when compared with controls.
CONCLUSION : In later life , there are many life experiences leading to change.
CONCLUSION : In Liguria a large portion of the health expenditure has been devoted to diagnostic and therapeutic resources.
CONCLUSION : In male physicians aged @number@ years or older , long-term use of a daily multivitamin did not provide cognitive benefits.
CONCLUSION : In many persons with SSD , QOL is not static in later life and one third improved their QOL.
CONCLUSION : In men , older age did not affect control of bone metabolism , but bone turnover was reduced.
CONCLUSION : In Nigerian patients with symptomatic prostate enlargement , serum tPSA should be seen as a continuum with increasing risk of prostate malignancy.
CONCLUSION : In nonobese subjects , fasted serum ACs are associated with Si and fat mass.
CONCLUSION : In @number@ independent samples , perceived sex discrimination amplified the effect of antagonism on cigarette smoking for women but not men.
CONCLUSION : In older adults , CP are independent predictors of incident VaD and may improve VaD risk prediction.
CONCLUSION : In older adults , muscular dysfunction is associated with cognitive impairment.
CONCLUSION : In older adults with coronary heart disease , depressive symptoms and lower exercise capacity predicted functional decline over @number@ years.
CONCLUSION : In older men exceeding current guidelines on physical activity , more time spent in sedentary behavior is associated with greater mortality risk.
CONCLUSION : In older nursing home patients with type @number@ diabetes , severe hypoglycemia was significantly higher in dementia.
CONCLUSION : In older patients presenting to the ED , the addition of CT-proET-1 or MR-proADM to NT-proBNP improves diagnostic accuracy of AHF.
CONCLUSION : In older patients with AF , anticoagulant underuse was mainly associated with antiplatelet use.
CONCLUSION : In older people , not only large but also small numbers of medications may affect the risk for them to sustain injurious falls.
CONCLUSION : In older persons , gait speed and recall memory are independent predictors of expected survival.
CONCLUSION : In oldest old , higher BP is associated with better muscle strength.
CONCLUSION : In our case series , we found that CEUS could be useful in the assessment and follow-up of a PVSA.
CONCLUSION : In our cohort , testosterone levels were low but progressively increased from premenopause through post menopause.
CONCLUSION : In our large MS cohort , focal WM damage appeared to be the most relevant predictor of the long-term cognitive outcome.
CONCLUSION : In our series average CT is not significantly changed in STGD in comparison with the controls.
CONCLUSION : In our study , obesity was associated with a lower risk of long-term death but not with 30-day mortality after ICH.
CONCLUSION : In our systematic review , cognitive impairment was one of the strongest preoperative risk factors for postoperative delirium after hip fracture surgery.
CONCLUSION : In participants with high baseline homocysteine levels , increased plasma B12 was associated with RKF.
CONCLUSION : In patients on hemodialysis , the presence of diabetes was associated with both low and high AAI.
CONCLUSION : In patients over @number@ years , renal function is going to deteriorate as long as the excess of weight persists.
CONCLUSION : In patients with FTLD and predominantly early-onset AD , the NIA-AA AD dementia criteria have high specificity but lower sensitivity.
CONCLUSION : INP with diabetes have a significantly more negative attitude toward insulin therapy in comparison to patients already on insulin.
CONCLUSION : In recent years , the cardiovascular mortality had significantly increased , which was mainly due to the increase of ischemic heart disease mortality.
CONCLUSION : In retrospect , both procedural and demographic details play a crucial role in patient selection for same day discharge post coronary percutaneous intervention.
CONCLUSION : In screening settings , the TMT would have clinicians uselessly consider driving cessation in nine drivers out of ten.
CONCLUSION : In some elderly people , the binocular I / 4 isopter area is smaller than the visual impairment grade @number@ criteria.
CONCLUSION : Insomnia impacts psychomotor performance and subjective sleepiness differently , based on age group.
CONCLUSION : Insomnia is prevalent in childhood and adolescence , and is moderately heritable.
CONCLUSION : In summary , active ageing was observed in people with better health and functional performance.
CONCLUSION : In summary , breaking up sedentary time and time spent in sedentary behaviour are associated with frailty in older people.
CONCLUSION : In summary , nebivolol , through β3AR , is able to induce lipolysis and promote thermogenic and mitochondrial genes.
CONCLUSION : In summary , WB-EMS showed positive effects on the parameters of sarcopenia and regional fat accumulation.
CONCLUSION : Integrative reminiscence interventions are cost effective , have rapid impact , and carry a certain appeal to older adults.
CONCLUSION : intellectual activity and physical exercise were associated with better cognitive states in Asian older adults.
CONCLUSION : Intensity-thresholds depend on VO2max , gender and Actigraph-axis.
CONCLUSION : Interest in working with older adults was significantly related to positive attitudes , more knowledge and formal previous contact.
CONCLUSION : Internal fixation remains warranted in patients older than @number@ years with non-displaced intra-capsular PFFs.
CONCLUSION : Interpersonal differences in facial animation exist among Koreans.
CONCLUSION : Intervention participants performed better on dual-task activities and had better postural balance and greater functional capacity than controls.
CONCLUSION : In the absence of feedback and goal setting , wearing a monitoring device does not significantly increase physical activity.
CONCLUSION : In the current study , the hypothesis of an association between age at menarche and age at natural menopause was not confirmed.
CONCLUSION : In the elderly , low heart rates are associated with an increased risk of AF.
CONCLUSION : In the population studied , healthy behaviors were associated with lower incidence of functional disability.
CONCLUSION : In the present study , neurologic diseases , HNC , male sex and underweight were associated to impaired swallowing efficacy.
CONCLUSION : In the present study , the VSM test detected differences in VSM function among NC subjects and subjects with MCI and mild dementia.
CONCLUSION : In the present study , we established age-specific reference values for circulating AMH levels in the eumenorrheic female population.
CONCLUSION : In the real clinical world , Permixon is considered an appropriate treatment for BPH as both monotherapy and in combination with alpha-blockers.
CONCLUSION : in the UK and Ireland , most longitudinal and nationally representative cross-sectional studies do not include or follow-up older adults in care homes.
CONCLUSION : In this 85-year-old population , patterns of cardiac and pulmonary conditions were better than a single morbidity in explaining hospitalization.
CONCLUSION : In this case-control study , alterations in consciousness and inattention , assessed prior to falling , were more common in patients who fell.
CONCLUSION : In this cohort of hospitalized older adults , impaired functional status was an independent risk factor for severe CDI.
CONCLUSION : In this convenience sample of Australian centenarians , anxiety and depression was relatively nonexistent , and most reported a high quality of life.
CONCLUSION : In this cross-sectional analysis , HbA1c level is not associated with the presence or absence of incontinence.
CONCLUSION : In this first longitudinal study of drug use in nonagenarians , individuals used an increasing number of drugs as they aged.
CONCLUSION : In this interim analysis , no new safety signals were observed.
CONCLUSION : In this large cohort of community dwelling older people , we observed lower serum IGF-I levels in the higher age categories.
CONCLUSION : In this large study , greater adherence to the Mediterranean diet was associated with longer telomeres.
CONCLUSION : In this pilot clinical study in situ polymerizing collagen was shown to be safe and effective throughout the 3-month study period.
CONCLUSION : In this population-based study we observed that the association between CAC and GFR is modified by age.
CONCLUSION : In this population with little VitD deficiency , even moderately low VitD was associated with poorer performance on multiple domains of cognitive function.
CONCLUSION : In this sample of non-demented older persons , subcortical infarcts contributed to an increased risk of depressive symptoms as well as cognitive impairment.
CONCLUSION : in this study , CaHA performed well , with a favorable safety and durability profile.
CONCLUSION : In this study , the LDF method was used for the first time in the workplace in Taiwan.
CONCLUSION : In this study , the prevalence of frailty was from @percent@ to @percent@ by different criteria and methodology.
CONCLUSION : In this study we confirmed the validation of the ULCEAT methodology by applying it in retrospect to RB using development process.
CONCLUSION : In this study , we validated a conversion table between MMSE and MoCA using a large multicenter sample.
CONCLUSION : Intradermal botulinum toxin A injection does not appear to have any benefit in facial rejuvenation.
CONCLUSION : intra-individual variability in simple reaction time appears to have a robust association with mortality over @number@ years.
CONCLUSION : Intrauterine exposure of ECFCs to GDM induces unique phenotypic alterations.
Conclusion : Intravenous allo-hMSCs were safe in individuals with aging frailty.
CONCLUSION : Intravitreal ranibizumab therapy was effective in significantly increasing mean BVCA and reducing CRT.
CONCLUSION : In very old individuals , CAC and maximum IMT were positively associated with systemic inflammatory activity only in those above the 75th percentile.
CONCLUSION : In vivo MPT provides high-resolution images allowing the identification and quantification of cellular morphometric parameters.
CONCLUSION : In walnuts with low initial moisture , lipoxidation products increased markedly during storage and these products might provide the source for LFLP accumulation.
CONCLUSION : In well-functioning older persons living in the community environmental aspects of housing demonstrated a weak association with PA.
CONCLUSION : In women aged @number@ and older , changes in body composition and grip strength were associated with changes in SUI frequency over time.
CONCLUSION : IOD and long duration of CTO do not affect procedural and clinical outcome of patients who underwent CTO PCI.
CONCLUSION : IOP readings measured using the RBT and GAT showed within the allowable range in the late elderly subjects with or without glaucoma.
CONCLUSION : IOP was significantly decreased with age , although the amount of change was small.
CONCLUSION : IPL-PDT and red-light-PDT showed better rejuvenation effect than IPL or red light alone on the neck skin.
CONCLUSION : IR is inversely associated with HGS among older men without diabetes.
CONCLUSION : Iron deficiency and chronic kidney disease are the strongest predictors of RLS in older hospital patients.
CONCLUSION : Iron deposition in the brain during aging decreases water diffusion and increases the degree of anisotropy.
CONCLUSION : ISAV may reduce costs compared with standard mucormycosis therapy.
CONCLUSION : It cannot be concluded that facial exercises are effective.
CONCLUSION : It is an ideal method to treat scar contracture of digital web-spaces with distal palm perforator mini-flap.
CONCLUSION : It is debatable whether inclusion of gait speed is necessary when screening for sarcopenia in community-dwelling older adults.
CONCLUSION : It is important to develop a systematic public-health strategy and research specific to primary prevention of dementia in Thailand with the evidence-based medicine.
CONCLUSION : It is possible that the level of adiponectin in plasma reflects its level in CSF.
CONCLUSION : It is suggested that clinical sites select one hand placement technique for the measure to provide consistency of protocol.
CONCLUSION : It is worthwhile to investigate efficacy of this training program in a large randomized trial.
CONCLUSION : It was clear from the breadth of the data that meaningful supports and interventions must be multidimensional.
CONCLUSION : It was possible to develop and field test nationally agreed quality standards for memory services.
CONCLUSION : IVA technology can effectively activate residual follicles in some patients with POI and allow them to conceive their own genetic offspring.
CONCLUSION : IVDD is similar in humans and dogs.
CONCLUSION : IVR is a productive modality for falls research among older adults.
CONCLUSION : Jagged1 could activate Notch signaling pathway effectively.
CONCLUSION : Japan is an aging society.
CONCLUSION : Keeping BMI in an overweight status and stable is related to a reduced mortality.
CONCLUSION : Key measures of efficacy and safety in geriatric patients with T2DM were not significantly different from non-geriatric patients when utilizing insulin lispro.
CONCLUSION : KY group showed short- and long-term improvements in executive functioning as compared to MET , and broader effects on depressed mood and resilience.
CONCLUSION : Lack of insurance and Medicaid only were associated with significantly lower survival for patients with NHL.
CONCLUSION : LA is an independent predictor of poor neurological outcome in patients with spontaneous supratentorial ICH.
CONCLUSION : LAP and its association with diabetes are influenced by both age and gender.
CONCLUSION : Laparoscopic surgery in elderly women for benign gynecological disease is feasible , efficient , and safe.
CONCLUSION : LAR can be a form of chronic perennial rhinitis that has previously been considered to be non-AR.
CONCLUSION : Larger muscle mass was significantly associated with smaller retinal artery size in older people.
CONCLUSION : Laser-assisted treatment offers a successful solution for patients who have been suffering from disfiguring nodules from injected fillers-often for many years.
CONCLUSION : Laser prostatectomies are effective in dealing with lower urinary tract symptoms.
CONCLUSION : Late-life depression was not associated with increased cellular aging.
CONCLUSION : Late-life onset of migraine with aura is not rare in clinical practice and can occur without headache , especially in elderly individuals.
CONCLUSION : later born cohorts of 75-year-olds are less dependent in ADL and more engaged in leisure activities compared with earlier cohorts.
CONCLUSION : L-carnitine combined with tadalafil is safe and effective for the treatment of LOH with ED.
CONCLUSION : Lead exposure in male workers is an important factor for deterioration in bone mineral density.
CONCLUSION : Leg strength and fat mass best predict physical function in older adults and the relative importance varies according to age and sex.
CONCLUSION : Less blue light reached the retina with tinted IOLs than with untinted IOLs.
CONCLUSION : Level of education has a clear effect on the periodontal health status in the elderly.
CONCLUSION : Levels and patterns of cytokines changed over time and demonstrated associations with domain-specific cognitive functioning that varied over time.
CONCLUSION : Levels of physical activity were very low and time being sedentary was high.
CONCLUSION : Levels of serum HCY are associated with hsTnT levels in the elderly , indicating a relationship between HCY and subclinical myocardial damage.
CONCLUSION : Levels , types and location preferences of physical activity differed substantially by gender.
CONCLUSION : LGB could clearly be identified on QSM in the brain in vivo.
CONCLUSION : Lifelong occupational exposure to loud noise and / or ototoxic chemicals was significantly associated with hearing loss among elderly Latino Americans.
CONCLUSION : Life satisfaction in the older follows distinct trajectories.
CONCLUSION : Lifestyle variables appear to be strong and independent predictors of longevity in initially healthy middle-aged men.
CONCLUSION : Lifetime cumulative adversity is associated with a more noticeable process of age-related dysfunction across various markers of health.
CONCLUSION : Limited but promising evidence shows that appropriate interventions can improve health outcomes of non-transported older people who have fallen.
CONCLUSION : Lip augmentation with SGP-HA showed excellent safety with the assessments used in this study.
CONCLUSION : Lipoprotein properties were severely impaired in the AF group with increased extent of oxidation and inflammation.
CONCLUSION : little research has focussed on drug cessation.
CONCLUSION : LKB1 is required for chondrocyte AMPK activity , thereby inhibiting matrix catabolic responses to inflammatory cytokines.
CONCLUSION : LLDI is a good instrument to assess disability in low-income populations.
CONCLUSION : LMW HA of approximately @number@ kDa shows better penetration abilities than larger-sized HA.
CONCLUSION : Loading caused a compromise in start-up time and walking speed.
CONCLUSION : Longitudinal changes in IGF-1 levels can be used to predict a patient's vertical facial growth.
CONCLUSION : Longitudinal changes in rFTC detect subtle metabolic changes in individuals associated with variations in their cognition.
CONCLUSION : Long-lived individuals have a young epigenetic age compared with their chronological age.
CONCLUSION : Long sleep duration , particularly in old women , can affect thigh muscle attenuation ( increase in intramuscular fat ) .
CONCLUSION : Long-term alpine skiing on a regular basis may contribute to healthy aging by its association with a healthier life style.
Conclusion : Long-term residential exposures to air pollution and noise are associated with increased incidence of self-reported hypertension.
CONCLUSION : Long-term TCSs are at risk of premature hormonal aging.
CONCLUSION : LONMO / LONMOSD is particularly severe , with a high rate of motor impairment and death.
CONCLUSION : Loss of lean tissues occurs exponentially with aging.
CONCLUSION : Loss of spouse increases the risk of people getting psychiatric care , both for severe and minor psychiatric conditions.
CONCLUSION : Loss of weight in obese older persons is a strong biomarker of impending expansion of multimorbidity.
CONCLUSION : Low body fat or a pronounced decline in adiposity is associated with increased risks of mortality in frail older women.
CONCLUSION : Lower back pain is propounding health problem in male dancers and increases with age that cannot be resolved by decreasing training intensity.
CONCLUSION : Lower BP in midlife is associated with longer life and better physical HRQoL in old age.
CONCLUSION : Lower cardiac index is associated with an increased risk for the development of dementia and AD.
CONCLUSION : Lower carotid artery stiffness in endurance-trained adults is associated with better neuropsychological outcome and greater occipitoparietal perfusion.
CONCLUSION : Lower extremity performance ( SPPB ) was significantly higher in the PA compared with HE group.
CONCLUSION : Lower muscle mass and central adiposity appear to be important risk factors for mortality in HIV-infected individuals.
CONCLUSION : Lower nocturnal melatonin levels were associated with worsened daytime sleepiness , sleep efficiency , and shorter sleep time in older men.
CONCLUSION : Lower protein intake was associated with increased risk of mobility limitation in community-dwelling , initially well-functioning older adults.
CONCLUSION : Lower wealth , but not income , may be associated with prevalent and incident diabetes among older adults in UK.
CONCLUSION : Low health literacy combined with the physiological changes of aging put the elderly in a vulnerable position.
CONCLUSION : Low LF / HF activity was observed in long-term care elderly and was related to an increase of overall mortality.
CONCLUSION : Low MBFV in the anterior and posterior cerebral circulation was associated with worse lower extremity function and balance in older adults.
CONCLUSION : Low mood was more strongly associated with aMCI than with global cognitive impairment.
CONCLUSION : Low mtDNA content in peripheral blood is related to decreased femoral neck BMD in postmenopausal women.
Conclusion : Low serum @number@ , 25D and 25D concentrations at baseline are independently associated with the incidence of sarcopenia over the subsequent @number@ years.
CONCLUSION : L-polylactic acid is a filler that facilitates natural correction of ageing with minimum adverse event.
CONCLUSION : LS predicted death , but certain aspects of LS are more strongly associated with death.
CONCLUSION : LUTS affects the physical and social aspects of sufferers.
CONCLUSION : LUT SEPs can be induced in middle-aged women with reliable N1 responses.
CONCLUSION : LV functional parameters determined by means of gated 201Tl SPECT need to be corrected for sex and algorithms.
CONCLUSION : LVH assessed by electrocardiogram associates with steeper decline in cognitive function of older subjects independent of cardiovascular risk factors and co-morbidities.
CONCLUSION : Maintaining a competitively active lifestyle increases MS in LMA adults and may support healthy aging.
CONCLUSION : Maintaining body weight , physical activity , and strength were positively associated with BMD even in very elderly men.
CONCLUSION : Maintaining or increasing PA levels may attenuate age-associated physical performance decline.
CONCLUSION : Majority ( @percent@ ) patients were under @number@ years as against the Western epidemiology.
CONCLUSION : Male and age were significantly associated with CAVI≥9.
CONCLUSION : Male preponderance in CSDH provides valuable information about human cerebrum.
CONCLUSION : Male sex was found to be a significant risk factor of corrected QT prolongation in elderly hospitalized patients.
CONCLUSION : Malnutrition at admission is prevalent and associated with prolonged LOS.
CONCLUSION : Malnutrition risk is highly prevalent among elderly ICU patients , especially among severely ill patients with malignancy admitted to the emergency ward.
CONCLUSION : Management of drug prescriptions in patients with swallowing difficulties is not optimal , and may even have iatrogenic effects.
CONCLUSION : Many dentists experience the MSDs , especially in cervical region , as a consequence of occupational stresses.
CONCLUSION : Many family caregivers wish to stop cancer screening tests as dementia progresses and are relieved when physicians bring it up.
CONCLUSION : Many older adults continue be sexually active well into advanced age ( 80 + ) .
CONCLUSION : Many older adults with long-term SCI do not reach the amount or intensity of LTPA needed to achieve fitness benefits.
CONCLUSION : Maternal smoking during pregnancy did not influence childhood retinal arteriolar and venular calibers.
CONCLUSION : Maternal-specific RSV Ab decline rapidly following birth.
CONCLUSION : MAT is sufficiently reliable when used by auditors with minimal training.
CONCLUSION : MCAs apparently improve several clinical biomarkers in a cohort of patients under pharmacist's follow-up.
CONCLUSION : MCCs are increasingly prevalent among the older ( ≥65 y ) population and among children and adolescents.
CONCLUSION : MCI is characterized by extreme variability and instability.
CONCLUSION : Meals served in nursing homes are not entirely consumed by their residents.
CONCLUSION : Mean subfoveal choroidal thickness in healthy adults is approximately @number@ μm.
CONCLUSION : Measurement of AMH at cancer diagnosis predicts long-term ovarian function after chemotherapy.
CONCLUSION : Mécano-Stimulation is a noninvasive and safe technique delivered by flaps microbeats at various frequencies , which can significantly improve the skin trophicity.
CONCLUSION : Mechanical loading changes proteoglycan content.
CONCLUSION : Medical conditions were common among U.S. Chinese older adults , yet screening and treatment rates were fairly low.
CONCLUSION : Medicare costs are related to common markers of \ "silent \ " cerebrovascular disease and atrophy.
CONCLUSION : Medication review is important in the prediction and treatment process of depression as it can moderate the impact of social functioning and polypharmacy.
CONCLUSION : Medication underuse was associated with frailty and adverse non-cardiovascular clinical outcomes.
CONCLUSION : Melatonin appears to be a marker of disease state and severity , as well as of sleep disorders , in the elderly.
CONCLUSION : Memory impairment and apathy are not useful discriminative symptoms in diagnosing AD , DLB , and FTD.
CONCLUSION : Men and women appear to have different serum sclerostin responses to vitamin D and calcium supplementation.
CONCLUSION : Menatetrenone is an effective and safe choice in the treatment of postmenopausal osteoporosis in Chinese women.
CONCLUSION : Menopausal status , by itself and not as a consequence of aging , is associated with increased serum nitric oxide concentrations.
CONCLUSION : Menopausal status in women has significant influence on both choroidal and peripheral blood flow ; the opposite behaviour occurs with ageing.
CONCLUSION : Metabolic syndrome was seen in almost half of the patients with ED.
CONCLUSION : Methodological variability and study limitations do not enable conclusions regarding optimal dairy intake and cognitive performance to be drawn.
CONCLUSION : MetS accelerates age-associated arterial changes , even in older persons.
CONCLUSION : MetS was found to be a risk factor for advanced polyps.
CONCLUSION : MFRS is an effective method to improve skin laxity.
CONCLUSION : Middle-aged adults experienced declines in both sensory and cognitive processing.
CONCLUSION : Middle-aged and elderly individuals , once having diabetes , deserve HCC surveillance to reduce HCC mortality.
CONCLUSION : Midlife overall and abdominal adiposity were similarly associated with lower executive functioning scores.
CONCLUSION : Midlife PA may contribute to maintenance of cognitive function and may reduce or delay the risk of late-life dementia.
CONCLUSION : Mid-life proteinuria was an independent predictor for late-life incident all-cause dementia and cognitive decline over @number@ years.
CONCLUSION : Midlife to older rural US women with prehypertension were eating some of the foods that would help them meet mineral recommendations.
CONCLUSION : Migrants and urban dwellers had similar NCD risk-factor profiles.
CONCLUSION : Mild age-related decline in cognitive function is mainly due to the neuropathologic lesions traditionally associated with dementia.
CONCLUSION : Minimal invasive spinal techniques are greatly adapted to the management of fragile patients.
CONCLUSION : miRNA play an important role in maintaining normal skin physiology and skin regeneration.
CONCLUSION : Mirror fixation distance increases with age in infants and has a good correlation with acuity card results.
CONCLUSION : Mode of delivery and aging affect pelvic floor function.
CONCLUSION : Moderate and advanced liver fibrosis / cirrhosis are associated with an increased risk of CHF.
CONCLUSION : Moderate-intensity PA substantially reduces the risk of persistent MMD in older persons with functional limitations with MetS but not in those without MetS.
CONCLUSION : Moderate or greater hearing impairment in older adults is associated with lower levels of physical activity independent of demographic and cardiovascular risk factors.
CONCLUSION : Modifiable risk factors for CVD may play a role in the development of age-related hearing loss.
CONCLUSION : More healthy people tend to share certain characteristics of social networks.
CONCLUSION : More than half of all persons with symptomatic knee OA are younger than @number@ years of age.
CONCLUSION : More than half of fall patients had an adverse event within @number@ months of presenting to the ED after a fall.
CONCLUSION : More than @percent@ of golfers return to on-course play within @number@ year of lumbar fusion surgery.
CONCLUSION : More than @percent@ of young men have EF preserved @number@ years after PB.
CONCLUSION : Mortality amongst centenarians is not changing despite improvements at younger ages.
CONCLUSION : Most ED utilization by individuals with diabetes and schizophrenia is for increasing numbers of comorbidities rather than the index conditions.
CONCLUSION : Most of the characteristics in relation to cognitive impairment identified in our analysis are potentially modifiable.
CONCLUSION : Most of the nonagenarian subjects with functional and / or cognitive impairment at baseline had died at five-year follow-up.
CONCLUSION : Most of the PA cases evaluated in this study were benign.
CONCLUSION : Most studied biomarkers associated with SB were of cardiovascular or metabolic origin.
CONCLUSION : Most supplements used by children are not under the recommendation of a health care provider.
CONCLUSION : Moves towards universal health coverage in the US may reduce disparities in hypertension management.
CONCLUSION : MP and RSV were the most common pathogens in respiratory tract infection in hospitalized children.
CONCLUSION : MPOD is related to cognitive function in older people.
CONCLUSION : MRI is a useful tool for assessment of the whole spine.
CONCLUSION : MRI may be applied for studying the morphological and functional changes of normal major salivary glands with aging.
CONCLUSION : Multi-domain interventions that reverse frailty among community-living older persons also reduce depressive symptomatology.
CONCLUSION : Multimorbidity prevalence occurs in a high percentage of the Spanish population , especially in the elderly.
CONCLUSION : Multimorbidity was identified in over two-thirds of the elderly with frequently occurring chronic diseases.
CONCLUSION : Multiple approaches should be offered to older persons with memory complaints.
CONCLUSION : Multiple aspects of VI may contribute to mobility limitations in older adults.
CONCLUSION : Multiple medical comorbid diseases are common in older adults , especially in those with cognitive impairment.
CONCLUSION : Multi-state Markov model was an effective tool in dealing with longitudinal data.
CONCLUSION : Muscle biopsy using a Weil-Blakesley conchotome is both feasible and acceptable in community dwelling older men participating in epidemiological research.
CONCLUSION : Muscle quality declines progressively with age over the adult life span and is affected by obesity and neurological factors.
CONCLUSION : Musculoskeletal pain is associated with several aspects of sexual functioning.
CONCLUSION : Mutations in Nesprin-2 and lamin A are characterised by complex genotype phenotype relations.
CONCLUSION : Namibia's PLT transition shows that collections from repeat apheresis donors can reduce TTI risk and production costs.
CONCLUSION : Nasal alar necrosis associated with dermal filler injection is a rare event.
CONCLUSION : Nasolabial folds and periorbital wrinkles did not change throughout the study ; however , some aesthetic improvement was observed.
CONCLUSION : Natural health products for menopausal symptoms are easily available to Canadian women.
CONCLUSION : Nearly one in five individuals are admitted to NHs over a median of @number@ years of follow-up after ICD implantation.
CONCLUSION : Need-standardised DMP enrolment was fairly equitable across educational levels.
CONCLUSION : Negative immunostaining of eEF1A2 predicted for poor prognosis of NSCLC.
CONCLUSION : Neighborhood conditions appear to have significant , complex associations with psychosocial factors among middle-aged and older African Americans.
CONCLUSION : Neighborhood support networks and perceived proximity by walk to community facilities contribute significantly to depressive symptoms among low-income elders.
CONCLUSION : Neocollagenesis and dermal remodeling seen after ablative resurfacing contributes to the clinical improvement seen in tissue tightening.
CONCLUSION : Nephritis with mainly IgAN deposits , as an atypical LN , may be a special subtype of SLE.
CONCLUSION : Neuroautonomic evaluation is useful in older patients with unexplained syncope after the initial evaluation.
CONCLUSION : New parameters of LPND can achieve wrinkle improvement with few side effects.
CONCLUSION : New studies possibly will elucidate the present results among the divergence faced with other studies.
CONCLUSION : NFκB protein abundance is lowest and spontaneous eryptosis as well as susceptibility to Bay 11-7082 and parthenolide highest in aged erythrocytes.
CONCLUSION : NIA has supported the development of many interventions that include components of MOCs related to recommendations from the IOM report.
CONCLUSION : Nitrite-modified ECM increased VEGF , PEDF release , and C3a production in human iPSC-derived RPE cells.
CONCLUSION : NMSs in untreated de novo PD patients are more prevalent and severe with different domain involvement comparing to normal aging.
CONCLUSION : NOACs achieved a dominant market share over warfarin within @number@ years from receiving reimbursement in Norway.
CONCLUSION : No clear difference in treatment outcomes was seen between the elderly and the younger patients who received gemcitabine alone.
CONCLUSION : No consistent decline was observed longitudinally with exposure to RCF , although cross-sectional and longitudinal findings were discordant.
CONCLUSION : No evidence was found for a relationship between MetS or inflammation and cognitive decline in this sample of aging men.
CONCLUSION : No evidence was found that BRD differed from non BRD in terms of depressive symptoms and persistence.
CONCLUSION : No gender-dependent differences were observed in either the salivary or plasma lipofuscin levels.
CONCLUSION : Non-adherence was common across studies but little is known about the factors influencing non-adherence.
CONCLUSION : non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function.
CONCLUSION : Nonintentional fatality rates for older farmers have remained relatively unchanged for a significant period in Australia.
CONCLUSION : Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults.
CONCLUSION : Normative FCC data were established for four age groups ( 20s~40s , 50s , 60s , and 70s ) and gender.
CONCLUSION : NSO is a better alternative to ISCS to treat nasal mucosa symptoms due to aging.
CONCLUSION : NTC is as effective as onabotulinumtoxin A in the treatment of glabellar lines , and both products were well tolerated.
CONCLUSION : ( @number@ ) Biological age score plays an essential role in the evaluation of aging.
CONCLUSION : ( @number@ ) F-PBR111 shows a high specific signal in the healthy human brain in vivo.
CONCLUSION : ( @number@ ) I-MIBG myocardial scintigraphy is a good predictor of the future conversion of possible DLB to probable DLB.
CONCLUSION : Nurses and GPs share a very low willingness and high barriers to antipsychotic discontinuation.
CONCLUSION : Nurses are a key group to advocate for actions needed to prevent social isolation.
CONCLUSION : Nutritional status and nutritional care of residents with dementia were significantly associated with their psychological well-being.
CONCLUSION : Nutritional status is a factor that is independently and positively associated with functional limitation and disability.
CONCLUSION : Nutrition risk is common among aged individuals living in the community.
CONCLUSION : nvH1N1 infection in child could be associated with severe central autonomic dysfunction.
CONCLUSION : OAT in elderly patients with NVAF in our hospital is underused , especially in those patients with higher risk of stroke.
CONCLUSION : Obese very old women have a high WC but their HS is relatively low in relation to their Wt and FFM.
CONCLUSION : Objective impairment measures were not associated with distress in partners or supporters.
CONCLUSION : Ob pregnant women have increased inflammation and oxidative stress , and lower levels of nutritional antioxidant defenses compared with Lc pregnant women.
CONCLUSION : Observed increases in alpha frequency in children and decreases in the elderly were consistent with those from earlier studies.
CONCLUSION : Obtained results demonstrated that a single dose of L-arginine influences endothelium-dependent vasodilation predominantly in young , trained individuals.
CONCLUSION : OCT-based automated algorithms can be used to analyze and describe drusen and geographic atrophy burden in such population-based studies of elderly patients.
CONCLUSION : Offspring became the main source of secondhand smoke for the elderly.
CONCLUSION : Offspring of long-lived parents have lower risk of developing cancer compared with offspring of short-lived parents.
CONCLUSION : Of several psychological factors , only trait anxiety was significantly associated with CAC.
CONCLUSION : OHL was associated with greater risk of incident dementia in a multiethnic cohort.
CONCLUSION : Older adulthood is not necessarily a quiescent period , and there is considerable fluctuation in remission status.
Conclusion Older adults ' ability to manage their medication should be assessed using tools specifically built and validate for the purpose.
CONCLUSION : Older adults appeared to recruit later-occurring T-complex-like generators for gap processing , compared to earlier-occurring T-complex-like generators by the younger group.
CONCLUSION : Older adults have difficulty allocating sufficient attention for fast muscle recruitment when concurrently challenged by an attention-demanding task.
CONCLUSION : Older adults in the highest-ERA-scoring group had the highest utilization of CABG or PCI.
CONCLUSION : Older adults may discriminate less amongst specific affect terms or may experience greater affective heterogeneity.
CONCLUSION : Older adults prioritize postural control by sacrificing cognitive performance when faced with dual-tasking.
CONCLUSION : Older adults reporting a poor appetite showed a different dietary intake pattern compared to those with ( very ) good appetite.
CONCLUSION : Older adults ' self-rated health may be related to their executive functioning and to their loneliness.
CONCLUSION : Older adults should promote their health physically , psychologically , and socially.
CONCLUSION : Older adults who live in NH and use of wheelchairs represent a diverse cohort.
CONCLUSION : Older adults with depression and cognitive deficits can benefit from CBTs.
CONCLUSION : Older adults with hearing loss are at greater risk of dementia than those with normal hearing.
CONCLUSION : Older adults with long-term spinal cord injury report a low presence of probable depression.
CONCLUSION : Older adults with peripheral arterial disease are experiencing food insecurity.
CONCLUSION : Older adults with schizophrenia had a lower rate of auditory verbal hallucinations than had been reported previously for younger persons with schizophrenia.
CONCLUSION : Older adults with schizophrenia rarely achieve successful aging and do so much less commonly than their age peers.
CONCLUSION : Older age , worse IADL and cognitive functioning , and higher comorbidity were recognized as endangering one's long-term survival.
CONCLUSION : Older Americans are not meeting dietary guidelines and there are differences by gender and ethnicity.
CONCLUSION : Older healthy women can improve episodic and working memory through spending time on a challenging physical or mental activity.
CONCLUSION : Older ICU survivors have a high burden of palliative care needs that persist @number@ month after discharge.
CONCLUSION : Older inhabitants of urban areas , rural areas , and those residing in institutions have different expectations for individual nursing care.
CONCLUSION : Older men with higher physical activity levels demonstrate better physical function and mobility than their less-active peers.
CONCLUSION : Older patients are more vulnerable to detrimental effects of Gamma Knife radiosurgery on hearing.
CONCLUSION : Older patients were more frequently affected by undesirable clinical attributes of comorbidity , obesity , and physical inactivity.
CONCLUSION : Older patients with SCCP had increased risk of poor cancer-specific survival.
CONCLUSION : Older people aged @number@ years and older with sarcopenia have more chance for reduction in mobility.
CONCLUSION : Older people who are not in employment are at higher risk of poor physical and mental health.
CONCLUSION : Older people with diabetes who seem to be aware of hypoglycaemia report mostly non specific symptoms.
CONCLUSION : Older persons show a range of readiness to engage in different aspects of ACP.
CONCLUSION : Older U.S. Veterans emphasize health behaviors , social engagement , and dispositional characteristics as key determinants of successful aging.
CONCLUSION : Older women with AD are more likely to use psychotropic medications than older men , regardless of study population and country.
CONCLUSION : Olfaction is a strong predictor of memory recall.
CONCLUSION : Olfactory identification is similarly impaired in aMCI and naMCI.
CONCLUSION : Omega-3 fatty acids stimulate muscle protein synthesis in older adults and may be useful for the prevention and treatment of sarcopenia.
CONCLUSION : OnabotulinumtoxinA has demonstrated the ability to eliminate mild glabellar lines at repose for a significant number of patients.
CONCLUSION : onabotulinumtoxinA provides rapid onset ( one to two days ) based on physician and subject assessment.
CONCLUSION : OnabotulinumtoxinA provides significant reductions in POL severity and high levels of subject satisfaction.
CONCLUSION : OnabotulinumtoxinA was effective and well tolerated for treating moderate-to-severe CFL alone or in combination with GL.
CONCLUSION : On admission to the GEM unit , just over half the included patients were rated as malnourished defined by SGA category.
CONCLUSION : On average , RC residents take @number@ steps less per day and have approximately @percent@ of the living space of a CD.
CONCLUSION : One in seven community-dwelling elderly with newly diagnosed AD is at risk of malnutrition.
CONCLUSION : One in two patients with advanced cancer fell during follow-up of up to six months , regardless of age.
CONCLUSION : One stage debridement and closed-suction drainage therapy is an effective method for treating infection after lumbar instrumentation.
CONCLUSION : One-third of elderly patients will develop a recurrence following non-operative management of symptomatic biliary disease.
CONCLUSION : One-third of participants reported chronic pain , and close to one-fifth reported that this pain interfered with daily activities.
CONCLUSION : One third of patients waited longer than @number@ h for emergency surgery , with the elderly disproportionately represented in this group.
CONCLUSION : Only a minority of patients with hip fractures received prehospital analgesia.
CONCLUSION : Only Cobb angle showed significant correlation with ScoliScore among the socioclinical variables studied.
CONCLUSION : Only half of the previous service users were applicants , and they had severe diseases or were more dependent for their IADL.
CONCLUSION : Only the psychological approach to successful ageing independently predicted QoL at follow-up.
CONCLUSION : On the basis of systematic review of relevant literature , it appears that muscle fatigue induces clear deteriorations in reactive postural control.
CONCLUSION : On the basis of these findings , the SAH program should be viewed as a success.
CONCLUSION : Operational definitions improve the inter-rater reliability of ARWMC scale on CT , and it correlates with volumetric measurement.
CONCLUSION : Optical coherence tomography revealed various retinal morphologic changes associated with XLRS.
CONCLUSION : Optimized glycaemic control by add-on basal insulin improved indexes of endothelial damage and regeneration.
CONCLUSION : Oral PPE treatment is a possible option for improving the appearance of fine wrinkles below the eye in climacteric women.
CONCLUSION : Oral word-reading ability predicts cognitive performance better than years of education across individuals with different SES.
CONCLUSION : Orthostatic hypotension is prevalent among patients presenting to TIA clinic.
Conclusion : OSA recurrence during CPAP withdrawal increases FFA and glucose during sleep , associated with sympathetic and adrenocortical activation.
CONCLUSION : Osteoarthritic knee pain was more common in the apparent short leg.
CONCLUSION : OS was maximized in elderly patients who were able to get some surgical resection and undergo combined radiation and chemotherapy.
CONCLUSION : Otolaryngologists are encouraged to use olfactory tests in older adults to help predict the development of neurodegenerative diseases.
CONCLUSION : Our analysis found that speed significantly influenced the kinematic outcome parameters.
CONCLUSION : Our approach shows that aging affects hippocampus , parahippocampus , and fornix significantly but not cingulum.
CONCLUSION : Our case-control study suggests CETP 405V as a risk allele against longevity in Chinese.
CONCLUSION : Our classifier offers promising features for an accessible biomarker that predicts the risk of conversion to Alzheimer's disease.
CONCLUSION : Our data confirm the intervertebral disc as the most common etiology of chronic low back pain in adults.
CONCLUSION : Our data further indicate the role of CMV on circulating T cells , poor cognition and functional disability / dependency during aging.
CONCLUSION : Our data highlight the role of autophagy as a critical protective mechanism against mitochondrial dysfunction.
CONCLUSION : Our data indicated that KRAS status is predictive of cetuximab response in the Japanese population.
CONCLUSION : Our data indicate that at diagnosis , peripheral levels of cytokines and CCL5 display low values without any correlation with the cognitive status.
CONCLUSION : Our data indicate that rs490460 is associated with the risk of SZ.
CONCLUSION : Our data on pain indicate a definite need for action.
CONCLUSION : Our data show that periostin plays an important role for proper collagen assembly and homeostasis.
CONCLUSION : Our data suggest that acetylome signaling contributes to mitochondrial energy homeostasis by SIRT3-mediated deacetylation of ATP synthase proteins.
CONCLUSION : Our data suggest that dysregulation of the inflammatory response system is associated with a more severe form of depression more likely to re-occur.
CONCLUSION : Our data suggest that higher initial fitness in younger years contributed to higher fitness with aging despite an expected age-related drop in fitness.
CONCLUSION : Our data suggest that light PA may offer a protective influence of future cognitive ability in community dwelling older adults.
CONCLUSION : Our data support a determinant role for interleukin-10 ( @number@ ) polymorphism in the development of nosocomial infections.
CONCLUSION : Our data support previous suggestions of an association between transfusion of older RBCs and poorer outcome in cardiac surgery patients.
CONCLUSION : Our data support the association between rs823144 and decreased risk of PD.
CONCLUSION : Our equations were derived from a large data set and were found to be highly sensitive for both genders.
CONCLUSION : Our findings confirm that survival up to @number@ is a multifactorial phenomenon with similarities and specificities by gender.
CONCLUSION : Our findings highlight race differences in depression in older persons and encourage further research on the course of depression in older black patients.
CONCLUSION : Our findings highlight the importance of exploring expectations that might help to increase patients ' compliance.
CONCLUSION : Our findings indicated that stroke affecting the auditory cerebrum can cause acquired amusia with greater severity in RBD than LBD.
CONCLUSION : Our findings indicate that DTW is associated with prefrontal activation among older adults with mild cognitive impairment.
CONCLUSION : Our findings provide evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer's disease.
CONCLUSION : Our findings provide further evidence of microtopography as an independent , objective indicator of risk of SCC.
CONCLUSION : Our findings showed that BoNTA injections result in improvements in QOL and self-esteem.
CONCLUSION : Our findings suggest an increasing prevalence of asthma in Africa over the past two decades.
CONCLUSION : Our findings suggest that aging and atherosclerosis may be associated with severe OAB and poorer QOL.
CONCLUSION : Our findings suggest that a higher dose of clonidine may be needed during ECMO.
CONCLUSION : Our findings suggest that all six modified formulae developed in Asian populations may show great bias in elderly Chinese patients with CKD.
CONCLUSION : Our findings suggest that carotid plaques are a strong predictor of stable CAD.
CONCLUSION : Our findings suggest that fallers chose an early transfer of gaze strategy when challenged with an obstacle in DT conditions.
CONCLUSION : Our findings suggest that fractional Unipolar RF can be safely performed on the face and is effective in skin tightening.
CONCLUSION : Our findings suggest that low serum 25 ( OH ) D level may be associated with endothelial dysfunction in elderly Korean people.
CONCLUSION : Our findings suggest that oxidative stress is increased in postmenopausal women with psychological disturbances and low quality of life.
CONCLUSION : Our findings suggest that prebiotics affect the intestinal microbiota and might maintain the antibody titers in elderly individuals.
CONCLUSION : Our findings suggest that the 6BIO scaffold can be used for the development of novel antiaging compounds.
CONCLUSION : Our findings suggest that the dual-task method with an extended walking distance may be able to predict falls among community-dwelling older adults.
CONCLUSION : Our findings support recommendations to increase consumption of vegetables , particularly cruciferous vegetables , and fruit to promote cardiovascular health and overall longevity.
CONCLUSION : our findings support the view that modifiable lifestyle factors are an important component in health improvement.
CONCLUSION : Our findings underline the relevance of changes in sociodemographic variables as well as the occurrence of depression or dementia for functional impairment.
CONCLUSION : Our findings underscore the importance of considering cognitive impairment in the context of overall health.
CONCLUSION : Our hourly analysis delineated important differences in activity between the groups.
CONCLUSION : Our incidence of intermediate- and high-risk PCs in LTRs was slightly higher than in the general population.
CONCLUSION : Our integrated model of care for hip fractures can lead to satisfactory outcomes.
CONCLUSION : Our longitudinal findings suggest that interventions and services acknowledging caregiver values and the associated coping responses may prove beneficial.
CONCLUSION : Our meta-analysis proved both safety and efficacy for HA fillers.
CONCLUSION : Our method can be used as part of neuropsychological tests to differentiate the diagnosis between AD and DLB.
CONCLUSION : Our model provided precise estimates for the common cell types.
CONCLUSION : Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis.
CONCLUSION : Our preliminary data show that the use of an RMS is feasible and effective in promoting activation , self-care , and QOL.
CONCLUSION : Our preliminary data supports a superior form of thermoregulation for the purposes of skin tightening that integrates continuous subsurface and epidermal temperature monitoring.
CONCLUSION : Our presented findings highlight the potential anti-ageing activity of naturals products derived from the fruits of P. orientalis.
CONCLUSION : Our present study shows that the cone photoreceptor density is significantly reduced in HIV retinae compared with age-matched controls.
CONCLUSION : Our results call out for an increased focus on mental health interventions among older adults , especially for women living alone.
CONCLUSION : Our results clearly demonstrate that mouse and human contactin-2 are physiological substrates for BACE1.
CONCLUSION : Our results confirm in a large series of healthy subjects that basic motor performance deteriorates with age and is influenced by gender.
CONCLUSION : Our results confirm the antiwrinkle activity of acetyl hexapeptide-3.
CONCLUSION : Our results demonstrated that inequitable distribution of exposure to chemicals among populations within a country can occur.
CONCLUSION : Our results demonstrated the association between sputum levels of pentosidine and age-related small airways function in both normal controls and patients with asthma.
CONCLUSION : Our results demonstrated the safety of long-term TSH suppression on the cognitive function in elderly DTC patients.
CONCLUSION : Our results demonstrate that adding phytoestrogens to exercise training does not provide the additive effect for HRQoL in postmenopausal and overweight women.
CONCLUSION : Our results demonstrate that PLE has the protective effect against UV-induced dermal matrix damage.
CONCLUSION : Our results demonstrate that the effects of immunosuppressive drugs on PBMCs differ between young and elderly persons.
CONCLUSION : Our results encourage the use of SIAscopy as a tool to better gauge an individual patient's NMSC risk factors.
CONCLUSION : Our results find important coordinated aging patterns between different tissues.
CONCLUSION : Our results highlight that work in later life is influenced by sociodemographic characteristics , intrinsic capacity , and multimorbidity.
CONCLUSION : Our results highlight the importance of visual impairment for social ties in late life.
CONCLUSION : Our result showed that p.R268Q mutation in PMCA4 resulted in functional changes in calcium homeostasis in human neuronal cells.
CONCLUSION : Our results imply that the aged testis can be a good model to find associated proteins involved in age-related changes of the testis.
CONCLUSION : Our results indicate abnormalities of coagulation and fibrinolysis in FAP patients.
CONCLUSION : Our results indicate a mixed distribution pattern of several longevity indexes and different relation to GDPpc.
CONCLUSION : Our results indicate that different levels of BDNF methylation may be present in different populations and environments.
CONCLUSION : Our results indicate that psychological distress in elderly individuals is associated with increased risk of dementia-related mortality.
CONCLUSION : Our results indicate that the genotypic variants of DRD1 might play a role in the susceptibility of TD.
CONCLUSION : Our results indicate that working in older age can be a source of subjective health.
CONCLUSION : Our results offer evidence that topical EGF can reduce the appearance of under-eye bags.
CONCLUSION : Our results provided possible mechanistic insights explaining the effect of visible light on treating clinical conditions associated with ROS-mediated dysfunctions.
CONCLUSION : Our results provide strong evidence that trabecular thinning , which is associated with increasing age , decreases the relaxation rates.
CONCLUSION : Our results provide support for the use of white blood cell DNA methylation as a biomarker of exposure in EWAS.
CONCLUSION : Our results reveal a variety of social processes that may facilitate the effects of life-review therapy.
CONCLUSION : Our results revealed a prevalence of @percent@ of radiographical Scheuermann disease in Dutch individuals aged @number@ years and older.
CONCLUSION : Our results showed an association between stronger inner strength and being non-depressed.
CONCLUSION : Our results showed positive correlations between androgens and parasympathetic activity and between estradiol and sympathetic activity in men , independent from anthropometric factors.
CONCLUSION : Our results showed that both the walking and breathing groups presented improvement of pulmonary function.
CONCLUSION : Our results show that about half of patients admitted for acute illness have hypogonadism , mainly of non-hypergonadotropic type.
CONCLUSION : Our results show that PSAP has the potential to differentiate between primary and advanced PCa.
CONCLUSION : Our results substantiate the occurrence of oxidative stress during human aging.
CONCLUSION : Our results suggest a direct effect of nutritional parameters on HAI rather than an indirect effect mediated by immune parameters.
CONCLUSION : Our results suggest a significant impact of functional impairment on the incidence of nosocomial infections in hospitalized elderly population.
CONCLUSION : Our results suggest caution when BIA is to be applied in studies including undernourished older subjects.
CONCLUSION : Our results suggested that the hyperglycemia and renal function of patients with metabolic disorders correlated positively with the aging-associated telomeric changes.
CONCLUSION : Our results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with AD and MCI and correlates with antioxidant protection.
CONCLUSION : Our results suggest that CPT might lead to stronger long-term effects on attention.
CONCLUSION : Our results suggest that , CR affects metabolic parameters positively which will help especially pre-diabetic and insulin resistant patients without any pharmacological approach.
CONCLUSION : Our results suggest that elderly female patients with asthma have less understanding of inhaled steroid therapy , compared to elderly male patients.
CONCLUSION : Our results suggest that lacunar infarction may be associated with current periodontal disease in Japanese adults.
CONCLUSION : Our results suggest that left HV contributes in retrieval of visual memory in older adults.
CONCLUSION : Our results suggest that mild-intensity exercise could prevent prefrontal volume reduction due to aging and impede cognitive decline.
CONCLUSION : Our results suggest that PCL-based dermal fillers offer longer-lasting performance over NASHA-based dermal fillers in NLFs treatment.
CONCLUSION : Our results suggest that relative SMM is not lower in Asian populations compared with European populations after adjusted by age and BMI.
CONCLUSION : Our results suggest that RF is more efficient than CA in stimulating collagen synthesis.
CONCLUSION : Our results suggest that RJ improves tear volume in patients with dry eye.
CONCLUSION : Our results suggest that rs2229901 is associated with MDD risk.
CONCLUSION : Our results suggest that SHG and the SAAID index are useful indicators of facial skin aging in vivo.
CONCLUSION : Our results suggest that TG and FFA may play important roles in photoaging of human skin.
CONCLUSION : Our results suggest that the GSTP1 Val105 polymorphism confers excess susceptibility to the cognitive effects of cumulative lead exposure.
CONCLUSION : Our results suggest that this regimen is convenient , safe and promising , compared with conventional regimens for patients with metastatic colorectal cancer.
CONCLUSION : Our results support the hypothesis that environmental arsenic exposure increases the risk of myelomeningocele by means of interaction with folate metabolic pathways.
CONCLUSION : Our results support the notion of a specialized memory system for music.
CONCLUSION : Our results underscore the strength of the local connections between bone and marrow adiposity.
Conclusion Our retrospective study indicates that the annual incidence of CKD in Japanese patients with NAFLD is about @percent@.
CONCLUSION : Our significant findings illustrated the practical importance of this new analysis method.
CONCLUSION : Our studies identified at least one pathologic factor contributing to dysphonia in all elderly patients presenting with voice complaints.
CONCLUSION : Our studies suggest that zinc suppresses generation of NF-κB-regulated inflammatory cytokines by induction of A20.
CONCLUSION : Our study confirms the association between falls in the elderly people and psychotropic drugs.
CONCLUSION : Our study demonstrated that muscle mass and strength are lower in patients with osteoporosis.
CONCLUSION : Our study demonstrates and quantifies the effects of aging on the airflow dynamics and lung capacity.
CONCLUSION : our study demonstrates that associations of serum 25 ( OH ) D and PWV and IMT in an elderly population are not linear.
CONCLUSION : Our study demonstrates that SSS is deviated to the right side of sagittal suture in the majority of cases.
CONCLUSION : Our study establishes a stable model of social isolation to guide future research exploring the effect of social isolation on health after SCI.
CONCLUSION : Our study finds a new association between obesity , aging , and bile duct injuries which has never been reported in literature before.
CONCLUSION : Our study has demonstrated that a significant correlation does not exist between age of the patients and MPOD values.
CONCLUSION : Our study has detailed neurofunctional maps to use as normative references in future fMRI studies of emotional facial processing in psychiatric populations.
CONCLUSION : Our study has shown that there is no relationship between these diseases that increased with age.
CONCLUSION : Our study highlights the need for education and training for Irish GPs on FTD assessment in the older people patient population.
CONCLUSION : Our study is the first attempt at semiquantitative evaluation of the micromorphology maturation of the epidermal surface at the ultrastructural level.
CONCLUSION : Our study is the largest series performed in a population of adult HPVG patients in the ED.
CONCLUSION : Our study militates against the hypothesis that PC loss is pathognomonic of ET.
CONCLUSION : Our study provides the first evidence about significant hypothalamic alterations correlating with clinical outcomes of MS , using 1H-MRS.
CONCLUSION : Our study revealed an incidence and prevalence of HF in Germany which were largely comparable to those from other countries.
CONCLUSION : Our study reveals an independent association between skeletal muscle density and mortality in a community-based sample of older , predominantly Caucasian men.
CONCLUSION : Our study showed that BMI Z-score after @number@ months follow-up was similar for picky and non-picky children.
CONCLUSION : Our study showed that polypharmacy is associated with frailty.
CONCLUSION : Our study showed that the prevalence of both gout and hyperuricemia in Beijing remains substantial.
CONCLUSION : Our study shows that a weight loss intervention is accompanied by a significant increase in TL in overweight / obese adolescents.
CONCLUSION : Our study suggested that FTD could be heterogeneous with respect the age of symptom onset.
CONCLUSION : Our study suggests that head injury early in life may be an important risk factor for PD.
CONCLUSION : Our study suggests that inflammation pathways reported by these biomarkers only have a limited role in causing premature RBC death.
CONCLUSION : Our study underlines the high frequency of PSCI in a cohort of mild stroke.
CONCLUSION : Ours was the first survey on the epidemiology of LOH among old and middle-aged males in the rural area of China.
CONCLUSION : Our videoconference program alleviated depressive symptoms and loneliness in elderly residents in nursing homes.
CONCLUSION : Outdoor activity was an independent risk factor for cortical cataract , but was not risk factor for nuclear and posterior subcapsular cataract.
CONCLUSION : Outdoor physical activity barriers reflect the imbalance in person-environment fit among older people , manifested as unmet physical activity need.
CONCLUSION : Overall , at the current doses , neither ω-3 nor vitamin D supplementation significantly attenuated declines in torque associated with immobilisation.
CONCLUSION : Overall , at the current doses , ω-3 and vitamin D supplementation only attenuated one of the changes associated with non-injurious limb immobilisation.
CONCLUSION : Overall diagnosis and treatment rates increased over time.
CONCLUSION : Overall , efficacy and safety profiles of currently recommended vaccines are positive in the older population.
CONCLUSION : Overall , IPSS scores improved significantly following TURP and sexual function scored declined mildly.
CONCLUSION : Overall , @percent@ of FAST patients were not at target urate levels and required up-titration.
CONCLUSION : Overall , @percent@ of the studied population had at least one of the four diseases.
CONCLUSION : Overall , silica coating and silanization showed higher , stable bond strengths with and without aging.
CONCLUSION : Overall , the benefit of DHEA on muscle strength and physical function in older adults remains inconclusive.
CONCLUSION : Overall , the Measure was found to be culturally acceptable and required little modification.
CONCLUSION : Overall , the prevalence of inactivity was high , especially among people with SCD.
CONCLUSION : Overall , the prevalence rate of MCI and dementia were lower in Qena / Egypt than in other countries.
CONCLUSION : Overall , there was a growth in proximal humerus fractures treated in an inpatient setting in the United States.
CONCLUSION : Overall , this study found no associations between prostate cancer and the SNPs in DNA repair genes.
CONCLUSION : Overall , VKA control remains insufficient in very old patients.
CONCLUSION : Over a third of geriatric trauma patients had FS.
CONCLUSION : Over @number@ years , in the group studied , the total area of the detected objects remains quite constant.
CONCLUSION : Over one in five elderly dementia patients used drugs with clinically significant anticholinergic effects.
CONCLUSION : Over the 6-year period , PDMS-1000 was found to be effective and safe in the cosmetic practice setting.
CONCLUSION : Overweight is common for both sexes in the People's Republic of China , as are general and central obesity.
CONCLUSION : Overweight / obesity and higher CAD risk in midlife were associated with frailty @number@ years later.
CONCLUSION : Overweight / Obesity was found to be significantly associated with low concentrations of serum 25 ( OH ) in older Mexican adults.
CONCLUSION : Ov / ob prevalence increased between @number@ and @number@ in German children.
CONCLUSION : Oxidized-LDL and sVCAM might be used as endothelial dysfunction biomarkers for elderly with normal cardiovascular risk factors.
CONCLUSION : P66SHC , EP300 and HDAC1 probably play a role in cellular replicative senescence and oxidative-stress inducing premature senescence.
CONCLUSION : PA assessed by accelerometer is significantly associated with exercise capacity in patients with heart failure and is predictive of disease severity.
Conclusion : Pain is associated with an increased risk and intensity of frailty in older men and women.
CONCLUSION : PAOs are frequently detected in human atrium , where their presence is associated with clinical hypertension.
CONCLUSION : parental longevity is associated with better brain ageing in middle-aged offspring.
CONCLUSION : Parental loss should be considered as a potent adverse childhood experience with life-long consequences for health.
CONCLUSION : Parkinson's disease is the most common variant in the octogenarian population.
CONCLUSION : Participant and service provider perceptions of the rehabilitation program under study were generally positive.
CONCLUSION : Participants reported conflict because of the contradictory domains in which they work.
CONCLUSION : Participants were unanimous in their enjoyment and satisfaction with the programme , despite the lack of significance from standardised measures.
CONCLUSION : Participants who experienced syncope and / or non-accidental falls in the previous year have poor global cognitive performance compared with case-controls.
CONCLUSION : participation in life roles worsened over a 2-year period in some community-dwelling older men.
CONCLUSION : Participation in RMM did not show any statistically significant difference in the quality of life of the participants.
CONCLUSION : Particularly in the elderly with elevated levels of arterial stiffness , measurements of aPWV obtained with oscillometry and applanation tonometry show poor agreement.
CONCLUSION : Pathological changes takes place in the hippocampus and other subcortical gray matter structures in early-stage AD.
CONCLUSION : Patient personality has implications for the accuracy of mood disorder histories provided by friends and family members.
CONCLUSION : Patients aged < @number@ years had the best IVF outcomes , reflecting optimal reproductive capacity.
CONCLUSION : Patients in ESRD showed higher levels of EVA. cfPWV and EVA differed in ESRD patients depending on their renal failure etiology.
CONCLUSION : Patients over the age of @number@ are a relevant group in surgery.
CONCLUSION : Patients taking ChEIs were treated with less antipsychotics and anxiolytics than those not taking ChEIs.
CONCLUSION : Patients who have undergone repair of aortic coarctation frequently remain asymptomatic for a long time.
CONCLUSION : Patients with ELC had higher CAVI than normal subjects.
CONCLUSION : • Patients with PCa and lower testosterone levels have poor prognosis factors and higher tumour burden before treatment onset.
CONCLUSION : Patients with supratentorial ICH < 30 mL have high rates of poor outcome at @number@ days , regardless of location.
CONCLUSION : PA was associated with higher HRQL in younger adults.
CONCLUSION : PCCMCs provide a significant opportunity for supporting physicians to manage the care of persons with dementia within primary care practice.
CONCLUSION : PD is associated with a higher risk of AMI , which can be reduced by dental prophylaxis to maintain periodontal health.
CONCLUSION : PDR is more common in the palliative setting , but is also utilized among patients treated with curative intent.
CONCLUSION : Pedestrian-related injury has inverse association with victims ' income and educational level.
CONCLUSION : People living with HIV in Ontario , especially women , had higher prevalence of comorbidity and multimorbidity than the general population.
CONCLUSION : People with dementia were five times more likely to use antipsychotic drugs than the general population of older adults.
CONCLUSION : Perceived burdensomeness may explain the relation between depression and suicide ideation.
CONCLUSION : perceived severity of illness and self-reported health status are the most important factors when determining out-of-pocket health expenditure.
CONCLUSION : Performance losses in middle age are mainly due to a sedentary lifestyle , rather than biological aging.
CONCLUSION : Performance measures are independent predictors of relevant health outcomes , with the exception of falls.
CONCLUSION : Pericardial fat was associated with several inflammation and hemostasis biomarkers.
CONCLUSION : Personal memory was compromised in MCI , reflected by lower scores on the EAMI.
CONCLUSION : PET with ( @number@ ) C-vorozole is useful for assessing physiologic changes in estrogen synthesis capacity in the human body.
CONCLUSION : Photoaging , but not age alone , is associated with a smaller response to histamine in sun-exposed areas.
CONCLUSION : Physical activity , a keystone for blood glucose control , is difficult for older adults who are frail.
CONCLUSION : Physical activity reduced the risk of incident MCI.
CONCLUSION : Physical frailty is associated with all QoL domains , but these associations are largely explained by poor health characteristics.
Conclusion Physical inactivity is a treatable risk factor for stroke among those older than age @number@
CONCLUSION : PiB binding in WM is influenced by the presence of WML , which lower the signal.
CONCLUSION : PIM initiation was dependent on patient characteristics and possibly also some healthcare system-related factors such as differing regional treatment practices.
CONCLUSION : PIMs were found to be relatively common among older nursing home residents.
CONCLUSION : Pioglitazone added on CCBs significantly reduced coronary spasm compared with CCBs alone after @number@ months of treatment.
CONCLUSION : Plantar pressure presented a consistent pattern in the elderly.
CONCLUSION : Planus foot posture and pronated foot function are associated with foot symptoms.
CONCLUSION : Plasma adiponectin levels correlated negatively with body fat percentage in older males but not in older females.
CONCLUSION : Plasma arginine was lower in PEG patients with PU.
CONCLUSION : plasma cholinesterase activity can be a useful candidate biomarker to identify subjects at greater risk of developing postoperative delirium.
CONCLUSION : Plasma nitrite , RBC-NO , and BA OMC decreased with leg IPC.
CONCLUSION : PNB was not associated with lower mortality or lower cardiovascular complication rates when compared with epidural anesthesia in elderly patients with FNF.
CONCLUSION : Policy changes can have a significant impact on patient care.
CONCLUSION : Polymedication , inappropriate prescribing and drug interactions involving anti-cancer drugs are common and largely underestimated in elderly cancer patients.
Conclusion : Polypharmacy is associated with clinically relevant sarcopenia , as assessed by a low ALM / BMI.
CONCLUSION : Poorer life-space mobility interrelates with higher probability for depressive symptoms , thus compromising older adults ' mental wellbeing.
CONCLUSION : Poorer performance on the processing speed factor , a trainable factor , was independently associated with the most costly type of falls-injurious falls.
CONCLUSION : Poor functional vision is related to weaker balance and mobility performance in community-dwelling older adults.
CONCLUSION : Poor nerve function predicted lower strength and faster strength decline.
CONCLUSION : Poor physical health was hardly related to lower life satisfaction , whereas poor mental health was strongly related to lower life satisfaction.
CONCLUSION : Poor sensorimotor nerve function independently predicted mobility disability.
CONCLUSION : Population-based data on malignant tumors are available in the Czech Republic.
CONCLUSION : Positive coping approaches need to be developed by caregivers so as to continue their caring role.
CONCLUSION : Positive Prx @number@ expression is significantly correlated with recurrence and shorter DFS in patients with early-stage lung squamous cell carcinoma.
CONCLUSION : Post-absorptive muscle protein turnover is associated with muscle hypertrophy during resistance exercise training.
CONCLUSION : Postmenopausal women with decreased renal function are more likely to have a decreased BMD and greater arterial stiffness.
CONCLUSION : Postsurgical NSCLC participants found this rehabilitative exercise intervention highly acceptable because it removed traditional barriers to exercise.
CONCLUSION : Postural impairment and instability on TG was seen in earlier AD stages compared with instability on TUG.
CONCLUSION : Potentially inappropriate prescription was detected in more than half of patients receiving antihypertensive treatment.
CONCLUSION : power training is feasible for elderly persons and has a small advantage over strength training for functional outcomes.
CONCLUSION : Predictors of MCI progression need to be interpreted in light of the characteristics of the respective MCI sample.
CONCLUSION : Pregnancy weight gain did not contribute to the aging-related trend , but lifestyle changes of parenthood may later exacerbate the long-term trend.
CONCLUSION : Preliminary evidence suggests that a dementia-specific , aquatic exercise intervention reduces BPSD and improves psychological well-being in people with moderate to severe dementia.
Conclusion Preliminary experience suggests , ViV procedures with the Edwards Sapien @number@ THV are safe and reliable.
CONCLUSION : Premature frailty , like other non-AIDS-defining comorbidities , is a manifestation of HIV-related accelerated aging.
CONCLUSION : Prescreening under both vision assessment conditions will help identify and select superior vision performers.
CONCLUSION : preservation of cognitive abilities at the age of retirement can predict a successful ageing @number@ years later.
CONCLUSION : Preterm birth and accelerated infant growth are associated with narrower retinal arteriolar caliber in childhood.
CONCLUSION : Prevalence of BADL limitations is high among low-income older adults and increases with number of chronic conditions.
CONCLUSION : Prevalence of frailty was higher in Korea compared to previous studies in other countries.
CONCLUSION : Prevalent diabetes predicted lower cognition but not recent onset diabetes.
CONCLUSION : Preventing weight gain likely helps maintaining good physical health functioning and work ability.
CONCLUSION : prevention of chronic knee pain may reduce a considerable burden of mobility disability and increased risk of serious co-morbidity among older men.
CONCLUSION : Prevention of mobility loss with aging should focus on prevention and treatment of neuromuscular impairments.
CONCLUSION : Preventive measures and early therapeutic interventions that may alter the course of facial aging were defined.
CONCLUSION : Preventive surgical intervention needs to be appraised for osteoporotic patients at imminent and / or at very high risk of hip fracture.
CONCLUSION : Previous knowledge already available on the main constraints to influenza vaccination has not allowed to remove them.
Conclusion : primary and specialist AD patients differ in background characteristics , and this can influence diagnostic work-up and treatment.
CONCLUSION : Primary care physicians must consider many factors when determining if cognitive concerns might affect driving safety in older drivers.
CONCLUSION : Primary open-angle glaucoma poses a significant economic burden , which will increase substantially by @number@
CONCLUSION : Primary shoulder OA is not as rare as previously reported.
CONCLUSION : Projecting disease burden for GCA on a global scale allows for optimization of healthcare planning and prioritization of research domains.
CONCLUSION : Prolonged exposure to BC and SO₄ particles was associated with hypomethylation of two types of repetitive elements.
CONCLUSION : Prolonged QTc and Tpe are associated with endothelial dysfunction , arterial stiffness , impaired coronary perfusion and accelerated arterial aging.
CONCLUSION : Proposed protocol adjustments will increase test specificity and reduce administration time.
CONCLUSION : Protein digestibility is severely compromised in patients with CF as measured by this novel and easy-to-use stable isotope approach.
CONCLUSION : Proton pump inhibitors were not associated with greater risk of dementia or of AD , in contrast to recent reports.
CONCLUSION : Provided is a baseline profile of errors committed on tests of executive function across a range of age and educational levels.
CONCLUSION : Providing strategies for improving spirituality , such as teaching spiritual self-care , can improve their burden.
CONCLUSION : Proximal humerus fractures incidence increases with aging , especially in women.
CONCLUSION : PrU development involves important risk factors of prior PrU development and long-term-care facility placement as the @number@ largest risk factors.
CONCLUSION : PS-omega- @date@ have a favorable effect on memory in subjects with subjective memory complaints.
CONCLUSION : Psychosocial issues are part of the well-being of children with HIV.
CONCLUSION : PTH concentrations increase with age , independent of 25-hydroxyvitamin D , ionized calcium , phosphate , and renal function.
CONCLUSION : PTSS is prevalent in patients consulting in primary care practices.
CONCLUSION : Public policies should pay more attention to inequalities in access to community care.
CONCLUSION : Pulsed electromagnetic field at radiofrequencies may benefit patients with benign prostate hyperplasia treated by a non-invasive method.
CONCLUSION : Pure tone average ( low ) is significantly but minimally related to measure of general cognitive status.
CONCLUSION : QOL of older men is affected by physical , functional , and psychological factors rather than prostate cancer history.
CONCLUSION : Quality of life in menopausal women was greatly improved after @number@ weeks of yoga practice.
CONCLUSION : Quantitative and qualitative changes in the smooth muscle cells were due to both patient age and concomitant hypertension.
CONCLUSION : Racial differences in IADL independence are apparent long before stroke onset.
CONCLUSION : RACP can be safely applied to patients undergoing TEVAR for Stanford B dissection.
CONCLUSION : Radiofrequency energy can be applied to human facial , neck , and body skin to create tightening without surgical incisions and recovery time.
CONCLUSION : Raised ferritin values are frequently found in samples submitted from primary care and most so in adult males.
CONCLUSION : RAM was associated with metabolic syndrome in middle-aged men.
CONCLUSION : Rates of polypharmacy in NHs are high with significant variability.
CONCLUSION : RBC autoantibodies were detected by MS-DAT in more than a half of HS patients.
CONCLUSION : RBC storage under blood bank conditions produces numerous metabolic alterations.
CONCLUSION : Readmission after elective surgery may contribute to delays in functional recovery and persistent functional deficits in older adults.
CONCLUSION : Receiving too much instrumental support was related to sedentary behavior among depressed older adults.
CONCLUSION : Recovery after MTBI in older adults may be associated more with psychosocial than with biomedical or injury-related factors.
CONCLUSION : Recovery of mobility and reoperation rates after surgery of patients with AFFs were favourable and did not differ significantly from TFFs.
CONCLUSION : Reflectance confocal microscopy is a reliable diagnostic technique for evaluation of skin photoaging with objective criteria.
CONCLUSION : Regardless of age , ADC values decreased with fluid shift associated with time spent supine , whereas CSA and FA were not affected.
CONCLUSION : Regardless of the classification adopted , low weight is associated with frailty.
CONCLUSION : Regular exercise is important for maintaining or even improving mental and functional health , even for independent community-dwelling older adults.
CONCLUSION : Regular swimming exercise may result in improved eye hand coordination as faster and more accurate repetitive movements.
CONCLUSION : Regular tea consumption was associated with lower risk of neurocognitive disorders among Chinese elderly.
CONCLUSION : REM sleep imaging is a valuable tool with which to identify individuals at risk of developing AD.
CONCLUSION : Required ABT for license renewal was associated with lower rates of driving.
CONCLUSION : Research and policy implications are relevant to the National Plan to Address Alzheimer's Disease.
CONCLUSION : Research into whether medication regimen complexity is associated with nonadherence and hospitalization has produced inconsistent results.
CONCLUSION : Research suggests that it is important to engage in a range of health promoting behaviors to preserve good health.
CONCLUSION : Resection of the muscle may damage the intramuscular trigeminal branches , leading to sensory changes.
CONCLUSION : Residence within a disadvantaged U.S. neighborhood is a rehospitalization predictor of magnitude similar to chronic pulmonary disease.
CONCLUSION : Residing in a low-SES community was independently associated with depression after controlling for individual SES.
CONCLUSION : Resilience may reduce the negative influence of life stress on physical , emotional , and functional / global well-being in OPLWHA.
CONCLUSION : Respondents were most concerned about the poor reimbursement rates , but pharmacists who dispensed @number@ day supply of medications reported acceptable financial performance.
CONCLUSION : Restricting fatigue is common in community-living older adults.
CONCLUSION : Results confirmed that pairing of modules to obtain joint kinematics affects the accuracy compared to segment kinematics.
CONCLUSION : Results contradict the findings for broadband noise.
CONCLUSION : Results indicated ACT is feasible among persons with HF.
CONCLUSION : Results indicate that mild depressive symptoms in men and moderate / severe symptoms in women may represent a marker for future cognitive impairment.
CONCLUSION : Results of the present study showed a correlation between MetS presence and ED.
CONCLUSION : Results of this pre-planned meta-analysis in elderly patients with diabetes demonstrate a significant reduction in hypoglycaemic events with IDeg relative to IGlar.
CONCLUSION : RESULTS replicate and extend previous research by pointing to the multi-dimensional nature of the Future Time Perspective Scale.
CONCLUSION : RESULTS showed a positive relationship between dietary Si intake and bone regeneration.
CONCLUSION : Results suggested that competence-based training could be effectively administered through the telephone with the help of senior citizens trained and engaged as paraprofessionals.
CONCLUSION : Results suggest improved gait speed following physical activity program with no further improvement with added nutritional supplementation.
CONCLUSION : Results suggest that auditory post-processing is deficient in Alzheimer's disease , but is not typically related to sensory gating.
CONCLUSION : Results suggest that discrimination experiences accelerate biological aging in older African American males and females , alike.
CONCLUSION : Results suggest that early-stage COPD may have an impact on the LV diastolic function.
CONCLUSION : Results suggest that g accounts for most of , but not all , the tract-cognition associations in the current data.
CONCLUSION : Results suggest that low cognitive ability is a risk factor for depressive symptoms ; this association is partly due to shared genetic influences.
CONCLUSION : Results suggest that sleep duration is associated with preserving telomere length in a population of human immunodeficiency virus-infected adults.
CONCLUSION : Results suggest that the receipt of social support may be a burden for some older adults.
CONCLUSION : Results suggest that under the range of conditions examined , mcDESPOT can provide stabile and precise values.
CONCLUSION : Results suggest that vitD increases NO production and inducible NO synthase expression in osteoarthritic chondrocytes possibly leading to a protective effect.
CONCLUSION : Results suggest that when death is perceived to be nearer , emotional complexity is hampered , yet becomes relevant in buffering psychological distress.
CONCLUSION : Results support the safety and efficacy of SG for morbid obesity in patients aged≥60 years.
CONCLUSION : Retention of muscle mass and strength is integral to healthy aging.
CONCLUSION : Retinal NFL thickness was associated with a new history of self-reported glaucoma @number@ years later.
CONCLUSION : Retinol peel treatments can help to increase the amount of skin surface lipids in women during menopause.
CONCLUSION : Retinyl retinoate has a potent anti-wrinkle activity , and the PLA-retinyl retinoate microsphere could be a useful cosmeceutical product for anti-aging purposes.
CONCLUSION : Retrospective evaluate for pre-sarcopenia was easy to perform with CT findings.
CONCLUSION : Retrospective QSM computed from standard fMRI datasets provides new opportunities for brain iron studies in psychiatry.
CONCLUSION : RFA provided satisfactory 5-year survival rates in elderly patients with HCC.
CONCLUSION : RLS genetic risk markers are not associated with increased PD risk or subtype in the current study.
CONCLUSION : Rs7973260 , rs3756290 , and rs4481363 were not associated with SWB and DSs in Chinese elders.
CONCLUSION : rs877087 and rs2229116 of RYR3 gene are associated with atherosclerosis severity in Japanese.
CONCLUSION : RT001 was well tolerated and demonstrated an improvement in LCLs.
CONCLUSION : RT002 is a safe and effective BoNTA product with an extended duration of action.
CONCLUSION : RT measurement of the iOS app-based Token Test could be highly useful and convenient to better detect abnormalities in linguistic efficiency.
CONCLUSION : RV IVA , a marker of RV contractility , shows a strong dependence on HR.
Conclusions.
Conclusions.
Conclusions.
CONCLUSIONS : .
CONCLUSIONS.
CONCLUSIONS : 15-epi-LXA4 is an important mediator that protects the integrity of the human endothelium during corneal preservation in Optisol-GS.
CONCLUSIONS : A 26-wk group-based exercise program combined with dual-task training improved GCF in community-dwelling older adults without dementia.
CONCLUSIONS : A 4-week cycling regimen can normalize the modulation of reciprocal inhibition and functional performance in individuals with SCA.
CONCLUSIONS : ABCB1 @number@ TT genotype and older age might be a predictor of PIPN , which diminishes quality of life of cancer survivors.
CONCLUSIONS : A. bidentata and A. aspera are very promising to be fully utilized in the development of nutraceutical and pharmaceutical products.
CONCLUSIONS : Ability to function effectively at home , financial autonomy , and leisure are associated with clinically significant depression in octogenarian men.
CONCLUSIONS : Abnormal concentrations of these trace minerals may reflect oxidative damage and inflammatory response , thus increasing the severity of OSA.
CONCLUSIONS : Abnormal HRV parameters were significantly and independently associated with incident CHF in asymptomatic , older adults.
CONCLUSIONS : Abnormal spirometric findings in older adults without clinical lung disease are associated with increased heart failure risk.
Conclusions : About one-sixth of IADL limitations and one-fifth of social participation restrictions could be prevented by an optimal optical correction.
CONCLUSIONS : A brief , low-cost goal-setting intervention is feasible and acceptable , and has the potential to achieve increased activity engagement.
CONCLUSIONS : A broad measure of difficulty with functional activities can be meaningfully treated as a 3-domain construct.
CONCLUSIONS : A broad range of sociodemographic , physical , biological , lifestyle , and psychological factors show a longitudinal association with frailty.
CONCLUSIONS : Absence of BRINP1 causes deregulation of neurogenesis and impairments of neuronal differentiation in adult hippocampal circuitry.
CONCLUSIONS : ACA is more likely to be diagnosed in older individuals than any other manifestation of Lyme borreliosis.
CONCLUSIONS : Accelerated onset with increasing age and frequent persistence suggests considerable public health impact of disabling foot pain as the population ages.
CONCLUSIONS : Acceptance of technology in the pre-implementation stage is influenced by multiple factors.
CONCLUSIONS : Accepting the delegation to administer medication was inevitable and routine.
CONCLUSIONS : Access to online health information is increasing in popularity and can lead to a more informed health consumer.
CONCLUSIONS : According to the results , depression is the factor with the greatest influence on healthy aging.
CONCLUSIONS : ACDG and ACA decreased with age , and initial ACDG and ACA were related to the progression of open-angle glaucoma.
CONCLUSIONS : Acid sphingomyelinase inhibition in stored pRBCs offers a novel mechanism for improving the quality of stored blood.
CONCLUSIONS : A combination of clinical and instrumental tools is useful to identify fallers in PD or parkinsonisms.
CONCLUSIONS : A combination of modifiable vascular risk factors in midlife is highly predictive of the likelihood of dementia decades later.
CONCLUSIONS : A combined exercise programme resulted in improved DBP and CRF irrespective of training two or three 60min sessions / week.
CONCLUSIONS : A common type of leisure-time sedentary behaviour varies across metabolic and obesity phenotypes.
CONCLUSIONS : A comparison with international data shows various indicators of health of older Romanian adults to be relatively worse.
CONCLUSIONS : A complex association may exist between BPA and hyperinsulinemia among adult U.S. men.
CONCLUSIONS : A comprehensive understanding of elder patient-physician interaction needs to include both-'listening ' and ' looking'-components of patient-centered communication.
CONCLUSIONS : A computerized system focusing on the clock drawing task might be sensitive to altered performance among elderly people with mild MDD.
CONCLUSIONS : Acoustic and perceptual measures do not demonstrate evident differences between elderly and young speakers in habitual intensity level.
CONCLUSION : Sacral structures have morphometric variations.
CONCLUSIONS : ActiveLifestyle assisted and motivated independently living and healthy older people to autonomously perform strength-balance exercises over @number@ weeks and had low dropout rates.
CONCLUSIONS : Activity of stair climbing is affected by age , medication use , the presence of lower extremity pathology and pain.
CONCLUSIONS : acute emergency department ( ED ) transfer is a considerable burden for residents of RACF.
CONCLUSIONS : Acute pancreatitis patients increased year by year in Beijing.
CONCLUSIONS : Adapted Interactive video dance is feasible for some healthy older adults and may help achieve physical activity goals.
CONCLUSIONS : ADC values may be a more sensitive parameter than T2 in assessing age and disc level related intervertebral disc changes.
CONCLUSIONS : Adding head movements to the SOT increased the separation of younger adults who were healthy and older adults who were healthy.
CONCLUSIONS : Addition of VSL # 3 increased bifidobacteria and supported adequate folate and vitamin B12 concentrations in subjects with low-grade inflammation.
CONCLUSIONS : A decrease in dGEMRIC indices was associated with an increase in cartilage thickness in the medial compartment.
CONCLUSIONS : A deeper understanding of the palliative care philosophy is needed to further develop and tailor care for the dying persons in nursing homes.
CONCLUSIONS : Adenosine powerfully counteracts contraction of detrusor smooth muscle , which is lost in the aging bladder.
CONCLUSIONS : Adherence to physical activity guidelines was associated with better functional fitness of older women.
CONCLUSIONS : Adherence to WCRF / AICR dietary recommendations is associated with lower risk of cancer among older adults.
Conclusions : A diet rich in vitamin D may prevent or delay progression to advanced AMD , especially NV.
CONCLUSIONS : AD illness representations may be a risk factor for developing burnout.
CONCLUSIONS : Adipokine levels do not seem to give relevant information in nutritional state assessment.
CONCLUSIONS : Adiponectin prevents EPC senescence by inhibiting the ROS / p38 MAPK / p16 ( INK4A ) signaling cascade.
CONCLUSIONS : A distinct bacterial community state ( CST IV-A ) with a low relative abundance of Lactobacillus is associated with VVA.
CONCLUSIONS : ADL stages showed clinically logical associations with other health-related concepts , supporting external validity.
CONCLUSIONS : ADMA attenuates the association of endogenous melatonin with night-time BP and dipping in the general elderly population.
CONCLUSIONS : Adolescents rated the appearance-based video higher than the health-based video in terms of usefulness of educational content and message appeal.
CONCLUSIONS : Adolescents with PLEs and self-awareness of mental distress are at high risk for suicidal problems , particularly those without help seeking.
CONCLUSIONS : AD progression is characterized by a small number of parameters governing changes in large numbers of correlated indicators of AD severity.
CONCLUSIONS : ADSC isolated from older animals show changes , including impaired proliferation and angiogenic stimulation.
CONCLUSIONS : Adults treated for deliberate self-harm frequently repeat self-harm in the following year.
Conclusions : Adult survivors of childhood medulloblastoma / PNET demonstrate pronounced risk for hearing impairment , stroke , lower educational attainment , and social independence.
CONCLUSIONS : Adults with CP experienced deterioration in health outcomes in the long term.
CONCLUSIONS : Advanced age confers increased risks and incrementally higher costs in patients undergoing cardiac operations.
CONCLUSIONS : Advance planning has increased over the last @number@ decades in Canada.
CONCLUSIONS : Advancing age adversely affected the predictive performance of CURB-65 score in NHAP but not CAP.
CONCLUSIONS : Adverse childhood events are related to continued vulnerability among older adults , enhancing the impact of chronic stressors.
CONCLUSIONS : Adverse effects of nocturnal oxygen desaturation on PWV are seen among normotensive individuals and are amplified with aging.
CONCLUSIONS : AD was associated with an increased risk of osteoporosis in the elderly cohort of Chongqing , China.
CONCLUSIONS : AED use seems to be common among Swedish institutionalized elderly , and institutionalization is a strong determinant of AED use.
CONCLUSIONS : Aerobic exercise alone or combined with RT improves glycemic control , SBP , triglycerides , and waist circumference.
CONCLUSIONS : Aerobic training has no effect on the SBP response to CSM in OADM subjects with V-CSH.
CONCLUSIONS : AF is associated with gross infarcts.
CONCLUSIONS : AFOP has nospecific features , and its diagnosis depends on pathological examination.
CONCLUSION : SAFS should be considered in patients with severe asthma and sensitization to fungi but without elevation of serum IgE.
CONCLUSIONS : After adjusting for age and race norms nocturia was common among United States men.
CONCLUSIONS : After adjustment for VAT , abdominal SAT was inversely correlated with the occurrence of MetS.
CONCLUSIONS : After controlling for possible factors , maximal occlusal force was positively associated with cognitive function directly as well as indirectly through dietary intake.
CONCLUSIONS : After integrated orthogeriatric treatment , a complicated course was seen in @percent@ of the patients with a hip fracture.
CONCLUSIONS : Age 80-85 is a transitional period when major health changes take place.
CONCLUSIONS : Age and fatness could explain BP values by only 3-30% , although BP was more influenced by fatness than by age.
CONCLUSIONS : Age and gender do not have major influence on the @number@ major cerebrovascular regulation mechanisms.
CONCLUSIONS : Age and sex have few and small effects on excitability parameters.
CONCLUSIONS : Age appears to modify the association between MetS and cognitive decline.
CONCLUSIONS : Age at development of AF in patients with CHD is relatively young compared with the patients without CHD.
CONCLUSIONS : Age beyond @number@ years represent a risk factor of death after LR and should be avoided after chemoembolization or in cirrhotic patients.
CONCLUSIONS : Aged care providers need to be responsive to the different sources of support that may be provided to older lesbian and gay people.
CONCLUSIONS : Age-dependent microdamage ( MDx ) accumulates excessively in human perilabyrinthine bone , where the bone turnover is almost absent.
CONCLUSIONS : Age differences between husbands and wives impact their relationship , including any particular marital issues encountered.
CONCLUSIONS : Age does not certainly affect recurrence in patients with bladder cancer treated with bacille Calmette-Guérin therapy.
CONCLUSIONS : Age , gender , ADL scores and falls were associated with a not favorable behavior trend in PAL.
CONCLUSIONS : Age , gender , and racial / ethnic differences in MAWT distributions exist in the general population.
CONCLUSIONS : Ageing is associated with development of insulin resistance in an Elderly Chinese population.
CONCLUSIONS : Ageing is associated with reduced food intake resulting in inadequate intakes in energy , and some nutrients.
CONCLUSIONS : Ageing-related stereotypic beliefs function as a factor lowering self-efficacy as well as decreasing health-promoting behaviours.
CONCLUSIONS : Age in itself should not be an absolute contraindication to any breast cancer therapy.
CONCLUSIONS : Age is an important factor affecting the pharmacokinetics of oxycodone.
CONCLUSIONS : A generally active daily life was , regardless of exercising regularly or not , associated with cardiovascular health and longevity in older adults.
CONCLUSIONS : Age only affects the balance rate under more complex sensory conditions.
CONCLUSIONS : Age , poor education , cognitive decline , and a history of stroke were predictors of conversion to dementia.
CONCLUSIONS : Age , PVWMC and left thalamic microbleed predict less cGM volume.
CONCLUSIONS : Age-related bone structure changes predominantly occur in the talar body , which poses a potential risk factor for total ankle replacement loosening.
CONCLUSIONS : Age-related change of macular and circumpapillary RNFL measurements can be detected in normal eyes and can affect the analysis of glaucoma progression.
CONCLUSIONS : Age-related changes in diastolic indices correlated with gender among hypertensive patients.
CONCLUSIONS : Age-related changes in fornix diffusivity measures appear subregion dependent and asymmetrical.
CONCLUSIONS : Age-related changes in the slopes of MF and MPF of erector spinae muscle occur in healthy men but not in healthy women.
CONCLUSIONS : Age-related decline in BMD is more pronounced in women than in men , but determinants of BMD are multiple and interrelated.
CONCLUSIONS : Age-related decrease in RNFLT varied according to sector.
CONCLUSIONS : Age-related differences in vBMD and microarchitecture in Chinese women differed by bone compartments.
CONCLUSIONS : Age-related functional deterioration was estimated precisely across both objective and self-reported outcomes.
CONCLUSIONS : Age-related miRNAs play a more important role than non age-related mrRNAs in the developmental and aging process of the human brain.
CONCLUSION ( S ) : Age-related normograms in infertile women without polycystic ovaries demonstrate a biphasic pattern of decreased antral follicles.
CONCLUSION ( S ) : Age-related normograms in non-PCO infertile women for the 3rd to 97th percentiles were produced.
CONCLUSIONS : Age-related OP changes precede those seen with a- ( photoreceptoral ) and b-waves ( postphotoreceptoral ) .
CONCLUSIONS : Age-related prevalence differences in GAD are meaningful epidemiological trends.
CONCLUSIONS : Age seemed to be a determinant for these outcomes.
CONCLUSIONS : Age-specific reference values of HSA indices for the Japanese female population were obtained.
CONCLUSIONS : Age was insignificant for both OS and transplant-related mortality.
CONCLUSIONS : Age was the most significant determinant of adjacent segment disc space height followed by genetic factors , specifically inflammatory genes.
CONCLUSIONS : Aging along does not lead to LA enlargement in subects , but it does when combined HT.
CONCLUSIONS : Aging and low HDL cholesterol levels are considered independent risk factors for a recurrence of ischemic stroke.
CONCLUSIONS : Aging and postmenopausal status may be aggravating factors contributing to redox imbalance and oxidative damage in ARMD patients.
CONCLUSIONS : Aging and postoperative electrolyte disorders ( hyponatremia and hypocalcemia ) are risk factors for postoperative delirium in patients undergoing orthopedic surgeries.
CONCLUSIONS : Aging changes the subcellular localization and function of mTOR in the RPE.
CONCLUSIONS : Aging did not affect the elastance responses but did affect central blood pressure and other ventricular systolic responses to acute inflammation.
CONCLUSIONS : Aging , endoscopic UC activity , and corticosteroid dose predispose to colonic CMV infection , as determined by mucosal PCR , in UC.
CONCLUSIONS : Aging has negative influence on testicular morphology and spermatogenesis , and the failure of spermatogenic cell development is evident from the spermatid level.
CONCLUSIONS : Aging increases IR in obese but not in lean and overweight women with PCOS.
CONCLUSIONS : Aging is an important risk factor for developing glaucoma and is a main factor which influences therapy and course of the disease.
CONCLUSIONS : Aging is associated with increases in ocular HOAs , independent of other possible confounding factors.
CONCLUSIONS : Aging mitochondrial dysfunction evaluated by metabolomic profiling is associated with MACEs , independently of standard predictors.
CONCLUSIONS : Aging-related abnormalities in patients with COPD are also found in smokers with minor lung dysfunction manifesting as a KCO decrease.
CONCLUSIONS : Aging was associated with reduced microvascular function in leg muscles , independent of PA.
CONCLUSIONS : A graded decrease in cardiac functioning is associated with features of brain aging.
CONCLUSIONS : A health promotion intervention in a socially deprived setting faces challenges but can be effective and feasible to implement.
Conclusions : A higher baseline arginine / asymmetric dimethylarginine ratio was associated with lower CVD incidence in a high cardiovascular risk population.
CONCLUSIONS : A higher quality dietary pattern was associated with better cognitive function @number@ years and even @number@ years later in apparently healthy middle-aged adults.
CONCLUSIONS : A high presentation level of distorted words can adversely affect memory even after intelligibility is equated for.
CONCLUSIONS : A high proportion of older patients had sub-optimal vitamin C status and this was associated with increased symptoms of depression.
CONCLUSIONS : A high proportion of patients with stage F0-F2 fibrosis progress to advanced liver fibrosis.
CONCLUSIONS : A high rate of suicide risk was found.
CONCLUSIONS : AIBD has the potential to be a large burden on ability to work and quality of life.
CONCLUSIONS : AIH is an important differential in elderly patients with cirrhosis or abnormal LFTs.
CONCLUSIONS : AII are more likely to be present in those with cognitive impairment.
CONCLUSIONS : Airway management may be challenging in patients with primary osteolysis syndromes.
CONCLUSIONS : A joint influence of relatively mild risk factors is associated with reduced memory performance , even in healthy adults.
CONCLUSIONS : A key finding is the necessity of meaningful user involvement in technology development , especially in communities struggling with the digital divide.
CONCLUSIONS : Alagebrium had no effect on hemodynamics , LV geometry , or exercise capacity in healthy , previously sedentary seniors.
CONCLUSIONS : ALA-PDT showed better skin rejuvenation effect than red light alone.
CONCLUSIONS : A large majority of Canadians are comfortable with proxy consent for low-risk research.
CONCLUSIONS : A large number of non-pharmacological interventions for BPSD were identified.
CONCLUSIONS : Alcohol and exercise were associated with selective protective effects and tobacco with selective harmful effects on cognitive function in middle-to-older aged women.
CONCLUSIONS : Alcohol consumption in late life is not fixed.
CONCLUSIONS : ALDH2 2synergistically exacerbates TS risk for CSA , probably through aldehydes.
CONCLUSION ( S ) : A linear relationship of AFC to age was found.
CONCLUSIONS : A link exists between RSN composite scores and specific attentional performance measures.
CONCLUSIONS : Alirocumab decreased LDL-C and LDL-apoB by increasing IDL- and LDL-apoB FCRs and decreasing LDL-apoB PR.
CONCLUSION : salivary amino acid levels may be regarded as markers of aging.
CONCLUSIONS : Allergic sensitization and particularly polysensitization rates widely differ according to asthma and rhinitis status.
Conclusions : Allo-hMSCs are safe and immunologically tolerated in aging frailty patients.
CONCLUSIONS : All participating countries are experiencing aging of their general population.
CONCLUSIONS : All patients receiving SET would have a higher chance of successful treatment in that cycle if they received DET.
CONCLUSIONS : All patients were very satisfied with their results.
CONCLUSIONS : All subtypes of age-related cataract were associated with an increased mortality with nuclear cataract having the strongest association among the @number@ cataract subtypes.
CONCLUSIONS : All tested groups showed very low TBS values.
CONCLUSIONS : All three fall interventions provided positive net benefits.
CONCLUSIONS : All three surgical modalities for BPH management were found to be safe.
CONCLUSIONS : All-trans-retinoic acid and inhibition of the MAP / ERK signaling pathway may be protective in carbonyl stress induced brain endothelial damage.
CONCLUSIONS : Almost half of the patients presenting with AF did not receive any AVK therapy before admission.
CONCLUSIONS : A logistic model predicted nonunion with reasonable accuracy ( AUC = 0.725 ) .
CONCLUSIONS : A lower BMI is associated with age , disease severity , and a higher risk of death in acute decompensated HF.
CONCLUSIONS : A low FMR1 allele ( CGG ( < 26 ) ) is associated with significantly poorer morphologic embryo quality and pregnancy chance.
Conclusions : ALS , regardless of site of onset , involves a loss of myofibers containing MyHCI + sto.
CONCLUSIONS : Alterations in TFT results during hospitalization are associated with long-term mortality in elderly patients.
CONCLUSIONS : Although alcohol abstinence was more common in depressed than in nondepressed older adults , @percent@ of depressed persons were at-risk drinkers.
CONCLUSIONS : Although associative in nature , these results support the notion that lifestyle factors can have long-term beneficial effects on youthful looks.
CONCLUSIONS : Although bowel function deteriorates with increasing age after operated HD , it is associated with only slightly decreased gastrointestinal quality of life.
Conclusions : Although direct extrapolation from cadavers to the in vivo situation cannot be made , cannulae showed more precision in placement of product.
CONCLUSIONS : Although ECMO adversely impacted survival in a contemporary cohort of adult lung transplant recipients , the negative effect centered on older patients.
CONCLUSIONS : Although IPF was the single most common diagnosis , the majority of elderly subjects had non-IPF ILD.
CONCLUSIONS : Although it is not possible to determine whether tinnitus is a predisposing factor to depression , these results suggest an association.
CONCLUSIONS : Although LAA volumes increase , LAAEF decreases with age in both sexes.
CONCLUSIONS : Although LAPS significantly affect longevity , such differential longevity does not result in differential lifetime reproductive success.
CONCLUSIONS : Although most residents are adequately exposed to surveillance strategies for SRMs , only @percent@ participated in an ablative procedure.
CONCLUSIONS : Although purely observational , our findings support the poor prognosis associated with psychosis and depression in AD.
CONCLUSIONS : Although self-reported driving distance categories may be adequate for studies entailing broad group comparisons , caution should be used in interpreting results.
CONCLUSIONS : Although the LFT and LFA were both significantly associated with LCSS , the LFA was a more sensitive measurement parameter.
CONCLUSIONS : Although the prevalence of COPD in Korea is high , the disease is underdiagnosed and most COPD patients are under-treated.
CONCLUSIONS : although the therapy group increased their strength training , they reduced their 6-min walking distance.
CONCLUSIONS : Altogether , our results show that LRRK2 mutations affect α-synuclein regulation and impair NF-κB canonical signaling in iPSC-derived neurons.
CONCLUSIONS : A majority of ADNI investigators support returning amyloid imaging results to ADNI participants.
CONCLUSIONS : Ambient traffic-related air pollution was associated with decreased cognitive function in older men.
CONCLUSIONS : A meaningful proportion of physicians expressed negative perceptions about generic medications , representing a potential barrier to generic use.
CONCLUSIONS : A mechanism of gene-by-environment interplay connects this form of early perturbation of infant-mother interaction , heightened CO ( @number@ ) sensitivity and anxiety.
CONCLUSIONS : AMH alone or in combination with FSH may be a useful indicator of LMT.
CONCLUSIONS : AMH is highly expressed and secreted from cumulus GCs of advanced age patients.
CONCLUSION ( S ) : AMH predicted biological age earlier than FSH or AFC.
CONCLUSIONS : A model of reversible cognitive frailty was a short- and long-term predictor of all-cause mortality and overall dementia , particularly VaD.
CONCLUSIONS : Among ambulatory elders , cognition is associated with incident mobility impairment and mobility decline.
CONCLUSIONS : Among community-dwelling older adults , a large proportion experienced multiple co-occurring symptoms.
Conclusions : Among euthyroid adults , lower TSH and higher FT4 are associated with an increased risk of hip fracture.
CONCLUSIONS : Among HIV-infected participants receiving antiretroviral medications , food insecurity is associated with unsuppressed viral load and may render treatment less effective.
CONCLUSIONS : Among nondiabetics , short- and medium-term PM2.5 were associated with higher FBG.
CONCLUSIONS : Among older adults with diabetes , better glycemic control may improve both short-term and long-term maintenance of lower-extremity function.
CONCLUSIONS : Among older moderate drinkers , those who engage in episodic heavy drinking show significantly increased total mortality risk compared to regular moderate drinkers.
CONCLUSIONS : Among older people , cholesterol levels were unrelated to mortality between the ages of @number@ and @number@
CONCLUSIONS : Among patients with CAD , elevated homocysteine is an independent predictor of suboptimal response to ASA , but not to ADP antagonists.
Conclusions : Among PLWH , most cancers are not diagnosed at younger ages.
CONCLUSIONS : Among prevalent MCI cases , baseline agitation , nighttime behaviors , depression , and apathy elevated the risk of incident dementia.
CONCLUSIONS : Among self-reported worriers , worry frequency provides limited clinical utility over and above physical symptom frequency.
CONCLUSIONS : Among subjects with some level of self-reported ED , progression and regression are common over a several-year period.
CONCLUSIONS : Among the Chinese oldest old , higher LDL-C level was associated with lower risk of all-cause mortality.
CONCLUSIONS : Among the @number@ plasma markers , increased GGT activity is the strongest predictor for existing and new-onset hypertension in Hong Kong Chinese.
CONCLUSIONS : Among the one-third of severe AS patients who died during follow-up , @percent@ of deaths were cardiovascular-related.
CONCLUSIONS : Among TILDA participants , educational attainment appears to influence early retirement through disability.
CONCLUSIONS : Among various activities , weight training had the strongest association with less WC increase.
CONCLUSIONS : Among very old subjects with established CVD , NT-proBNP was the strongest risk marker for cardiovascular events and cardiovascular mortality.
CONCLUSIONS : A multifactorial behavioral intervention emphasizing spices and herbs significantly reduced sodium intake.
CONCLUSIONS : An 8-week combined exercise program benefits body composition , especially lean mass , and positively affects isokinetic strength and CVD risk factors.
CONCLUSIONS : An abnormal 12-min walk as an indicator of functional decline among older people is associated with the presence of carotid artery plaques.
CONCLUSIONS : An abnormal SPPB score was associated with lower QOL.
CONCLUSIONS : An acute bout of RE increases SC content in young men at @number@ h and older women at @number@ and @number@ h.
CONCLUSIONS : An anatomical basis for wrinkles was identified among the specimens studied.
CONCLUSIONS : Anatomy of the orbit , prior surgical history , and sunkenness of the upper eyelid were all considered during preoperative planning.
CONCLUSIONS AND CLINICAL RELEVANCE : Behaviors relating to activity were substantially different between healthy cats and cats with signs of DJD-associated pain.
CONCLUSIONS AND IMPLICATIONS : Ambient intelligence technologies can contribute to an increased safety and security at home.
CONCLUSIONS AND IMPLICATIONS : Antibiotic use in patients with dementia is substantial , and probably highly associated with the particular healthcare context.
CONCLUSIONS AND IMPLICATIONS OF KEY FINDINGS : The decision to stop a medication by an individual is influenced by multiple competing barriers and enablers.
Conclusions and Relevance : Adults with childhood-onset epilepsy , particularly APOE ε4 carriers , have an increased brain amyloid load at late middle age.
Conclusions and Relevance : Advances in diagnosis can improve recognition and risk stratification of delirium.
CONCLUSIONS AND RELEVANCE : Among community-dwelling older adults , reports of shorter sleep duration and poorer sleep quality are associated with greater Aβ burden.
Conclusions and Relevance : Analyses confirm decreasing dementia incidence in this population-based sample.
CONCLUSIONS AND RELEVANCE : Application of topical products prior to microneedling can introduce immunogenic particles into the dermis and potentiate local or systemic hypersensitivity reactions.
CONCLUSIONS AND RELEVANCE : Better sleep consolidation attenuates the effect of APOE genotype on incident AD and development of neurofibrillary tangle pathology.
CONCLUSIONS AND RELEVANCE : Bitter blocking was less effective in children , and the efficacy of blocking was both age and compound specific.
CONCLUSIONS AND RELEVANCE : Brain DNA methylation in multiple AD loci is associated with AD pathologies.
Conclusions and Relevance : Colpocleisis are valuable procedures for women with severe pelvic organ prolapse who do not wish to retain coital function.
CONCLUSIONS AND RELEVANCE : Dietary TAC was inversely associated with the risk of age-related cataract.
Conclusions and Relevance : Dual-task gait is associated with progression to dementia in patients with MCI.
CONCLUSIONS AND RELEVANCE : Duration of diabetes and advancing age independently predict diabetes morbidity and mortality rates.
CONCLUSIONS AND RELEVANCE : Elevated cerebrospinal fluid VEGF was associated with more optimal brain aging in vivo.
Conclusions and Relevance : Even in elderly patients with advanced cSCC , cetuximab was efficacious and well-tolerated.
Conclusions and Relevance : Exercise alone and various combinations of interventions were associated with lower risk of injurious falls compared with usual care.
Conclusions and Relevance : Exposure to suicide is stressful and affects the bereaved spouse on a broad range of outcomes.
Conclusions and Relevance : Ganglion cell complex thickness appears to be highly heritable and further genetic analysis may help identify new biological pathways for glaucoma.
CONCLUSIONS AND RELEVANCE : Greater milk consumption during teenage years was not associated with a lower risk of hip fracture in older adults.
CONCLUSIONS AND RELEVANCE : Higher education / occupation scores were associated with higher levels of cognition.
CONCLUSIONS AND RELEVANCE Higher serum CML concentration had no significant cross-sectional association with prevalent AMD in this large population-based cohort of older adults in Iceland.
CONCLUSIONS AND RELEVANCE : Impaired sensorium significantly increases postoperative morbidity and mortality independent of other preoperative risk factors and comorbidities following nonemergent general surgical operations.
Conclusions and Relevance : Improvements in safety and efficacy for energy-based treatment have expanded the patient base considering these therapies viable options.
Conclusions and Relevance : In this study , altered AQP4 expression was associated with aging brains.
Conclusions and Relevance : Large PVSs are an MRI marker of SVD and associated with the pathogenesis of vascular-related cognitive impairment in older individuals.
CONCLUSIONS AND RELEVANCE : Longer donor leukocyte telomere length was associated with increased 5-year survival in patients who received HCT for severe aplastic anemia.
CONCLUSIONS AND RELEVANCE : Low-frequency coding variants with intermediate effect size may account for a significant fraction of the genetic susceptibility to AD and FTD.
Conclusions and Relevance : Low wealth was associated with death and disability in both the United States and England.
CONCLUSIONS AND RELEVANCE : Male sex is associated with worse memory and HVa among cognitively normal individuals , while APOE ε4 is not.
CONCLUSIONS AND RELEVANCE : Morphometric age correlated with mortality after liver transplant with better discrimination than chronologic age.
Conclusions and Relevance : Mothers who were exposed to higher levels of PM2.5 gave birth to newborns with shorter telomere length.
Conclusions and Relevance : Neither supplement prevented dementia.
Conclusions and Relevance : No evidence for preclinical change in personality before the onset of mild cognitive impairment or dementia was identified.
CONCLUSIONS AND RELEVANCE : Our data support the hypothesis that facial aesthetic unit separation influences perceived facial youthfulness among photographs of women.
CONCLUSIONS AND RELEVANCE : Our genetic data provide insights into aberrant cellular mechanisms responsible for this prototypical autoimmune disorder.
CONCLUSIONS AND RELEVANCE : Our results do not indicate involvement of changes in brain NET availability or distribution in the pathogenesis of ADHD.
CONCLUSIONS AND RELEVANCE Our results show that ROHs could significantly contribute to the etiology of AD.
CONCLUSIONS AND RELEVANCE : Our study confirms that a substantial proportion of cognitively normal older adults harbor neurodegeneration , without Aβ burden.
Conclusions and Relevance : Our trial demonstrated that propranolol was not inferior to steroid with respect to therapeutic effects in IH.
Conclusions and Relevance : Persistent pain was associated with accelerated memory decline and increased probability of dementia.
Conclusions and Relevance : Reflectance confocal microscopy improves LM diagnosis in photodamaged skin with good histopathologic correlation although false-positive and false-negative cases exist.
CONCLUSIONS AND RELEVANCE : Regular exercise was associated with lower 10-year cumulative incidence of olfactory impairment.
CONCLUSIONS AND RELEVANCE : Significant differences in the use of eye care services by SEP persist among US adults with eye diseases.
CONCLUSIONS AND RELEVANCE : The HIV + adults had significantly poorer lower-frequency and higher-frequency hearing than HIV- adults.
CONCLUSIONS AND RELEVANCE : The LMN systems of FTLD-TDP frequently exhibit neuropathological changes corresponding to ALS.
CONCLUSIONS AND RELEVANCE : The natural history of AMD demonstrates relentless loss of vision in persons who developed advanced AMD.
Conclusions and Relevance : The prevalence of dementia in the United States declined significantly between @number@ and @number@
Conclusions and Relevance : The protective factors that influence amyloid and AD-pattern neurodegeneration are different.
CONCLUSIONS AND RELEVANCE : The rate of major complications was significantly higher in Canada following TKA , but there was no significant difference following THA.
CONCLUSIONS AND RELEVANCE : The results provide strong evidence for potential candidate genes related to EEM on 6q24.
CONCLUSIONS AND RELEVANCE : The risk for cataract is increased among statin users as compared with nonusers.
CONCLUSIONS AND RELEVANCE : These findings further expand the phenotypic spectrum of SNCA locus duplications.
Conclusions and Relevance : The study findings provide novel mechanistic insights into PD and autoimmune diseases and identify a common genetic pathway between these phenotypes.
CONCLUSIONS AND RELEVANCE : This could be among the first studies establishing fornix degeneration as a predictor of incipient cognitive decline among healthy elderly individuals.
CONCLUSIONS AND RELEVANCE : Thyrotropin levels within the reference range are not associated with risk of CHD events or CHD mortality.
CONCLUSIONS AND RELEVANCE TO CLINICAL PRACTICE : Approaching indicates the ethical values that guide nurses in their caring encounters with older patients.
CONCLUSIONS AND RELEVANCE : We found the heritability of ALS to be significantly higher than previously reported.
CONCLUSIONS : Android adiposity and low moderate and vigorous PA are the strongest predictors of IR or diabetes among aging adults.
CONCLUSIONS : An easy and reliable measure of cardiovascular global performance is independently associated with cognitive function in older outpatients affected by CHF.
CONCLUSIONS : Anemia may be more prevalent in middle-aged workers than expected.
CONCLUSIONS : Anemia was associated with frailty in both cross-sectional and longitudinal analyses , and anemia precedes frailty in men who were nonfrail at baseline.
CONCLUSIONS : A new anthropometric PE has been developed that offers an alternative for clinicians when access to DXA is limited.
CONCLUSIONS : An exclusion from surgical therapy due to advanced age in general seems not to be justified.
CONCLUSIONS : an FBG level indicative of T2DM was associated with increased risk for cognitive impairment.
CONCLUSIONS : An increasing BMI in early life may shorten the lifespan of maturing cohorts as they age , particularly among women.
CONCLUSIONS : An integrated IADL and ADL functional assessment tool is valuable.
CONCLUSIONS : An interesting effect of gene induction by administration of NAC and amino acids in vitro was demonstrated.
CONCLUSIONS : An intricate protocol has been developed to conduct this study.
CONCLUSIONS : Anorexia of aging is importantly associated with frailty and the following frailty components : slowness , exhaustion , and weight loss.
CONCLUSIONS : An SPPB score lower than @number@ is predictive of all-cause mortality.
CONCLUSIONS : Antibody seropositivity against the analyzed pathogens with the exception of Ureaplasma does not seem to be a risk factor for PCa pathogenesis.
CONCLUSIONS : Anticholinergic medication might affect cognitive function in people with first cognitive complaints.
CONCLUSIONS : Antidepressant drug usage is associated with AD / dementia and this is particularly evident if usage begins before age @number@
CONCLUSIONS : Antihypertensive use overall was not statistically significantly associated with recurrent falls after adjusting for important confounders.
CONCLUSIONS : Antiplatelet and antithrombotic effects of chlorogenic acid are associated with the A2A receptor / adenylate cyclase / cAMP / PKA signaling pathway.
CONCLUSIONS : Anxiety makes a significant contribution to self-rated QOL in older people with serious mental disorders.
CONCLUSIONS : Anxiety sensitivity and intolerance of uncertainty are predisposing characteristics that appear to partially explain age-related differences in health anxiety.
CONCLUSIONS : Any age-related differences in visual acuity in the presence of defocus and astigmatism were swamped by interparticipant variation.
CONCLUSIONS : Any bleeding and TIMI major bleeding complications increase in patients aged ≥75 years treated with clopidogrel in addition to aspirin.
CONCLUSIONS : Any oxygen use among fee-for service Medicare beneficiaries with COPD is high.
CONCLUSIONS : APACHE II and ATN-ISI scoring systems can predict the hospital mortality of elderly AKI patients.
CONCLUSIONS : A parsimonious theoretical model was empirically evaluated , which enabled identifying direct and indirect associations with positive self-rated health.
CONCLUSIONS : APOA2 m265 genotype may be associated with eating behaviours and dietary modulation of plasma ghrelin.
CONCLUSIONS : ApoE4 + AD patients showed lower global amyloid burden and greater medial temporal hypometabolism compared with matched ApoE4- patients.
CONCLUSIONS : APOE but not ACE is associated with late-onset incident dementia in the population.
CONCLUSIONS : Apparently , a larger personal network is important for older adults ( 50 + ) to be more satisfied with life.
CONCLUSIONS : Appetite regulation is a complex , multifactorial construct.
CONCLUSIONS : Application of @percent@ estriol gel to the vulvar vestibule is effective in correcting menopausal coital pain.
CONCLUSIONS : Approximately one-fifth of community-dwelling older adults were facing the threat of sarcopenia in southern Taiwan.
CONCLUSIONS : Approximately one in five elderly persons experiences annual problems with dizziness or balance.
CONCLUSIONS : Approximately one in four ET patients reported whole days in the past two weeks in which they had not taken their medication.
CONCLUSIONS : Approximately one-quarter of the elderly population living in Sao Paulo could be taking two or more potentially interacting medicines.
CONCLUSIONS : Approximately @percent@ of women develop recurrence following exenterations done after chemoradiation.
CONCLUSIONS : A practice pharmacist-led DUE program improved the management of osteoporosis in general practice.
CONCLUSIONS : A preoperative and postoperative evaluation of function and cognition was integrated into the surgical care of older patients.
CONCLUSIONS : A progression in female reproductive stages was associated with bipolar illness exacerbation.
CONCLUSIONS : A prolonged QT interval is associated with an increased risk of incident AF.
Conclusions : A prominent change to a steeper slope of cognitive decline occurs between @number@ and @number@ years prior to the diagnosis of AD dementia.
Conclusions : A promising genetic signal for parental life span was identified but was not replicated in independent samples.
CONCLUSIONS : A provisional consensus definition of agitation has been developed.
CONCLUSIONS : Aqueous flare is increased in RP patients and negatively correlates with central visual function.
CONCLUSIONS : a range of factors identify those with FOF.
CONCLUSIONS : A range of typical end criteria are presented in a random sample of subjects aged 20-85 years.
CONCLUSIONS : a rational desire to avoid pain exacerbation and medical intervention motivated restrictions to activity.
CONCLUSION : Sarcopenia and central adiposity were associated with greater cardiovascular mortality and all-cause mortality.
CONCLUSION : Sarcopenia was an independent risk factor for dysphagia among older individuals.
CONCLUSIONS : Areal bone mineral density is lower in trained male road cyclists compared with recreational , specifically at the hips.
CONCLUSIONS : A relationship between age and LUTS was observed ; however , the metabolic syndrome did not show a clear association with LUTS.
CONCLUSIONS : A reliable extended-IADL scale was constructed meeting item response theory assumptions relating to unidimensionality , monotonicity , and invariant item ordering.
CONCLUSIONS : A resolution pathway exists in the brain and the alterations described herein strongly suggest a dysfunction of this pathway in AD.
CONCLUSIONS : A risk index based on @number@ blood-based markers was modestly able to predict cognitive decline over an 11-year follow-up.
CONCLUSIONS : Arterial stiffening accelerates with advanced age.
CONCLUSIONS : Arterial stiffening worsens across the stages of the menopausal transition in healthy women.
CONCLUSIONS : Arterial stiffness was associated with Aβ plaque deposition in the brain , independent of BP and APOE ε4 allele.
CONCLUSIONS : Artificially sweetened soft drink consumption was associated with a higher risk of stroke and dementia.
CONCLUSIONS : ARVd was associated with fewer hemodynamic variables than to 24-hour SBP.
CONCLUSIONS : As aging displays a unidirectional progression , it is unlikely that LTL elongates with age.
CONCLUSIONS : As among younger people , lifetime cigarette smoking history is a key determinant of mortality after age @number@ years.
CONCLUSIONS : As a whole , our findings are comparable to those reported in other surveys.
CONCLUSIONS : As compared with previous estimates , the prevalence of hypothyroidism rose by about @percent@ , driven mainly by non-iatrogenic forms.
CONCLUSIONS : Ascorbate content and the structure of the vitreous gel are critical determinants of lens oxygen exposure.
CONCLUSIONS : as currently defined in the TMG , maximum pedestrian crossing times at pelican crossings may represent a hazard for very old people.
Conclusions : A short behavioral sleep intervention may have important benefits in improving objectively measured sleep in older adults participating in ADHC.
CONCLUSIONS : A short food-based questionnaire provides useful information about the diet quality of older adults.
CONCLUSIONS : A significant proportion of older people are exposed to medicines with anticholinergic properties , including those dispensed acetylcholinesterase inhibitors.
CONCLUSIONS : A significant proportion of the population developed visually significant age-related cataract at @number@ years.
CONCLUSIONS : A single body-worn sensor can be employed in the community-setting to complement conventional gait testing.
CONCLUSIONS : A single injection of Hydros or Hydros-TA was well-tolerated and relieved pain associated with knee osteoarthritis over @number@ weeks.
CONCLUSIONS : A single measure of plasma FFA obtained later in life is associated with a higher risk of HF in older adults.
CONCLUSIONS : A slight decrease in serum AMH levels during the late night appears not clinically relevant.
CONCLUSIONS : As no effective medications for cataract are available at present , its current standard treatment is the removal of the clouded lens.
CONCLUSIONS : As pupil center uncertainty increases , so does the WFE variation in repeated measurements.
CONCLUSIONS : As seniors get older , they tend to have more severe mobility impairment and participate less in social activities.
CONCLUSIONS : Assessment of lower limb strength and power asymmetry is more reliable in mobility-limited elders when compared to healthy middle-aged and older subjects.
CONCLUSIONS : Assistance eases daily life and medicine regimen adherence.
CONCLUSIONS : Associations among psychological resources and glucoregulation were mixed.
CONCLUSIONS : Associations of testosterone and SHBG with MetS vary according to BMI and individual MetS components.
CONCLUSIONS : A standardized set of outcome measures will assist with better documentation and standardization of assessment practices of clinicians who manage spasticity.
CONCLUSIONS : A steady trend of decreasing AMI incidence was observed.
CONCLUSIONS : Asthma history was associated with baseline job type and subsequent job changes among nurses.
CONCLUSIONS : Astigmatism , especially mild astigmatism , was common in patients with cataract , which suggests the importance of astigmatism correction.
CONCLUSIONS : A strong relationship between happiness and social support networks promotes people's well being.
CONCLUSIONS : A structured PA program reduced the risk of MMD even in older adults with extreme obesity.
CONCLUSIONS : A substantial number of men prescribed testosterone therapy did not receive testosterone or PSA testing before or after initiating treatment.
CONCLUSIONS : A substantial portion of the COP burden occurs among elderly members of the Japanese adult population.
CONCLUSIONS : A substantial proportion of FSW in Burkina Faso started selling sex as minors.
CONCLUSIONS : A substantial proportion of patients with high viral load and ALT < @number@ × UNL have advanced fibrosis.
CONCLUSIONS : As with young adults with BD , alcohol misuse and medication non-adherence emerged as significant predictors of suicide ideation.
CONCLUSIONS : Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women.
CONCLUSIONS : At the present time , DEXA is considered the most reliable tool for evaluating bone remodelling after THA.
CONCLUSIONS : Audiology is now at the point where the search for biomedical interventions to modulate or prevent age-related hearing loss can move forward.
CONCLUSIONS : Auditory priming resulted in equivalent amounts of release from informational masking in both younger and older adults.
CONCLUSIONS : Australian parkrunners mostly reflect the general population on personal well-being , except report superior satisfaction with physical health.
CONCLUSIONS : Autologous fat processed by closed-membrane filtration had a significantly higher long-term retention rate than did centrifuged-processed fat injected by the same surgeons.
CONCLUSIONS : Automatic assessment of the layers ' intensities was achieved.
CONCLUSIONS : Available evidence on the socioeconomic determinants of PA behaviour across the life course is probable ( shows fairly consistent associations ) at best.
CONCLUSIONS : A variety of linguistic skills are affected by sleep deprivation.
CONCLUSIONS : Average time in bed in this Haitian sample was greater than previously reported for industrialized countries like the United States ( @number@ versus.
CONCLUSIONS : A Web-based health promotion program showed promise for making a significant contribution to the short-term dietary and exercise practices of older working adults.
CONCLUSIONS : A window of vulnerability to Pb neurotoxicity exists in the developing brain that can influence AD pathogenesis and cognitive decline in old age.
CONCLUSIONS : Baby boomer adults who self-report hearing impairment on direct inquiry are most likely to have a hearing loss.
CONCLUSIONS : Baby boomers expect to work longer than their predecessors.
CONCLUSIONS : Baby boomers reported significantly higher rates of CAM use than the silent generation for both chronic diseases and painful conditions.
CONCLUSIONS : B-age , estimated by DNA methylation , is an independent predictor of ischemic stroke outcome regardless of chronological years.
CONCLUSIONS : Baicalin can directly scavenge peroxynitrite and the peroxynitrite-scavenging ability contributes to its neuroprotective mechanisms against cerebral ischemia reperfusion injury.
CONCLUSIONS : Bariatric surgery may lead to lasting improvements in cognition.
CONCLUSIONS : Barriers must be addressed for these tools to be available to this growing population.
CONCLUSIONS : Based on CT measurements , the aorta-sacral promontory distance is decreased in elderly and hypertensive patients.
CONCLUSIONS : Based on current literature , it is difficult exactly indicate what are the standards of eyeball growth in children and youths.
CONCLUSIONS : Based on estimates of persistence , adherence , and switching , galantamine was the best tolerated ChEI and rivastigmine the least.
CONCLUSIONS : Based on MR imaging the development and fusion of the acromion and distal clavicle in children occur earlier than previously reported.
CONCLUSIONS : Based on national health statistics and US census data we can anticipate a substantial increase in the workload for head and neck surgeons.
CONCLUSIONS : Based on our findings , we postulate that age-associated biochemical changes may accentuate the inflammation associated with OAB.
CONCLUSIONS : Based on our results , we emphasise the importance of focusing public health efforts for those ≥65 years on preventing invasive bacterial infections.
CONCLUSIONS : Based on standing chest radiographic measurements , a right thoracic curvature was observed in normal spines after adolescence.
CONCLUSIONS : Based on these findings , suggestions for further research are made.
CONCLUSIONS : Based on World Health Organization criteria , anemia was found in @percent@ of elderly subjects studied.
CONCLUSIONS : Baseline cardiorespiratory fitness is related to longitudinal neuropsychological performance , and memory appears to be a particularly vulnerable domain.
CONCLUSIONS : Basic knowledge of stroke is insufficient among the general population of Extremadura.
CONCLUSIONS : BCN @number@ grading repeatability was not affected by the severity of the cataract.
CONCLUSIONS : BC was associated with adverse changes LF / HF in the elderly.
CONCLUSIONS : BD is associated with high rates of abnormal sleep and CRD.
CONCLUSIONS : BDR is correlated with increased FSH in women.
CONCLUSIONS : Before and after activity , older adults responded with a single outward step to arrest a fall less frequently than young adults.
CONCLUSIONS : Behavioral symptoms were significantly higher in those reporting SI.
CONCLUSIONS : Being exercise active predicts greater memory-related microstructural integrity in older adults.
CONCLUSIONS : Being younger and possessing more education was associated with greater eHealth literacy among baby boomers and older adults.
CONCLUSIONS : BE is associated with circulating inflammatory cytokines and leptin and low levels of anti-inflammatory cytokines.
CONCLUSIONS : Benzodiazepines pose an immediate threat to fall risk , whereas it is less clear if antipsychotics also pose an immediate risk.
CONCLUSIONS : Benzodiazepine users are at increased risk of activity limitations regardless of the duration of action or indication.
CONCLUSIONS : Better orthostatic tolerance might be an additional benefit of physical activity in older age.
Conclusions : Better overall CVH was protective against poor physical function in community-dwelling men and women aged @number@ years and older.
CONCLUSIONS : Better prognosis was obtained when ruptured aneurysm was repaired in the elderly than it was treated conservatively.
CONCLUSIONS : Better regulation of e-cigarette marketing messages on manufacturers ' websites is needed in China.
CONCLUSIONS : Between @number@ and @number@ SGAs were increasingly accepted in the outpatient treatment of adult nonpsychotic depression.
CONCLUSIONS : Between @number@ and @number@ the age-standardised prevalence of MS in Hobart increased threefold , and the incidence nearly doubled.
CONCLUSIONS : Biomarkers can be used to independently predict coincident AD and DLB pathology , a common finding in amnestic MCI and DAT patients.
CONCLUSIONS : Bipolar medication adherence may improve antiretroviral adherence among patients with bipolar disorder and HIV infection.
CONCLUSIONS : Black South Africans showed markedly shorter telomeres than did white South African counterparts.
CONCLUSIONS : Blood harmane appears to be elevated in PD.
CONCLUSIONS : Blue-yellow defects were quite common among the aged , becoming increasingly prevalent with increasing age.
CONCLUSIONS : BMI , but not PA , tracked well over @number@ years in this sample.
CONCLUSIONS : BMI is a significant predictor of decline of functional ability in Taiwanese adults ≥ @number@ years old.
CONCLUSIONS : Body mass index and fitness levels are the strongest predictors of myocardial lipid content in nonobese humans.
CONCLUSIONS : Bone and glucose metabolisms are probably connected through a complex pathway that involves leptin , osteocalcin , and adiponectin.
CONCLUSIONS : Bone density decay only theoretically provides a new method to determine age at death for adult females.
CONCLUSIONS : Both BZDs and marital status independently affect the risk for senior drivers to be involved in an RTC.
CONCLUSIONS : Both depression and transactional sex significantly improved the performance of the VACS index in predicting mortality among HIV-infected women.
CONCLUSIONS : Both DTCA and MCTA triplet pregnancies affected by TTTS are at high risk of adverse perinatal outcome.
CONCLUSIONS : Both frailty and cognitive impairment are predictors of mortality and the effect is cumulative.
CONCLUSIONS : Both genetic and socioeconomic factors may be important determinants of early kidney damage among AAs.
Conclusions : Both LTL and lung function variables are moderately to highly genetically determined.
CONCLUSIONS : Both older and younger patients can receive a significant improvement in speech perception with cochlear implantation.
CONCLUSIONS : Both overweight and obesity at midlife independently increase the risk of dementia , AD , and VaD.
CONCLUSIONS : Both peelings were effective in reducing fine wrinkles of the outer lateral eye area after three applications ( p ≤ @percent@ ) .
CONCLUSIONS : both poor SRH and SMC were associated with permanent NH placement risk among elderly primary care patients.
CONCLUSIONS : Both resting Pd / Pa and iFR showed similar associations with anatomic and hemodynamic stenosis severity and the risk of MACE.
CONCLUSIONS : both self-reports and objective measures capture information on the functional ability of older people that can be used to predict disability onset.
CONCLUSIONS : Both the AD8 and IQCODE were able to detect dementia in a community setting.
CONCLUSIONS : Both the EXIT and the Quick EXIT have adequate reliability and appear to require ECF in this population.
CONCLUSIONS : Both the number and pattern of chronic conditions were related to falls.
CONCLUSIONS : Bowman's layer thins with age in the normal cornea , losing one-third of its thickness between the ages of @number@ and @number@ years.
CONCLUSIONS : BQG improved the gait performance , functional mobility and sleep quality in older adults with PD at the 6-month follow up.
CONCLUSIONS : Brain AVMs in elderly patients still pose a high risk of hemorrhage.
CONCLUSIONS : Brain change with aging is characterized by extensive shrinkage of white matter.
CONCLUSIONS : Breakfast skipping was significantly associated with obesity among elderly.
CONCLUSIONS : Breath-hold calibration increased detection of working memory-related BOLD response differences between sedentary and endurance-trained adults.
CONCLUSIONS : Broadband polychromatic PBM showed no advantage over the red-light-only spectrum.
CONCLUSIONS : Brugada-ECG has increased prevalence among patients with schizophrenia.
CONCLUSIONS : Bulgaria has relatively high percentages of ( very ) severe COPD patients , resulting in considerable socio-economic burden.
CONCLUSIONS : BW is the most impact factor on the proximal tibial BMD after mid- to long-term follow up TKA.
CONCLUSIONS : By incorporating information on CRC risk alleles , we created a model to determine the risk for CRC more accurately.
CONCLUSIONS : By integrating human genetic and functional evidence , we identify several PD susceptibility gene candidates for further investigation.
CONCLUSIONS : By joining various datasets developed in different disciplinary traditions new possibilities for interdisciplinary research on ageing emerge.
CONCLUSIONS : By testing multiple cognitive domains and avoiding ceiling effects , MCI can be identified before age @number@ years.
CONCLUSIONS : CAB seems to be a useful supplement to MMSE and a screening instrument for MCI and dementia with good sensitivity and specificity.
CONCLUSIONS : CAD patients had reduced Treg and Treg / Teff ratio compared to healthy controls.
CONCLUSIONS : Calling for iterative and pragmatic programme design , the findings describe how to move towards a more inclusive health care environment.
CONCLUSIONS : Cancer survivors had slightly higher numbers of chronic conditions and poorer health status than controls.
CONCLUSIONS : Cancer survivors have reduced odds of developing AD and a lower burden of neurofibrillary tangle deposition.
CONCLUSIONS : Cardiac aging was progressive without sex differences in healthy participants.
CONCLUSIONS : Cardiovascular risk early in midlife is associated with poor motor performances later in life.
CONCLUSIONS : Cardiovascular risk prediction models are associated with cognitive changes over time and risk of dementia.
CONCLUSIONS : Careful multi-disciplinary assessment of older people is required before a compliance aid is provided.
CONCLUSIONS : Caregivers may have incomplete perception of patient NPS mainly in mild dementia.
CONCLUSIONS : Caregivers value interactive interventions that are tailored to their unique needs and the illness context.
CONCLUSIONS : Care homes are isolated communities of care.
CONCLUSIONS : cART started during chronic HIV is associated with reduced neuronal-glia and inflammatory markers.
CONCLUSIONS : Cataract , especially its nuclear component , affects MPOD measured by autofluorescence spectrometry.
CONCLUSIONS : CBI dissatisfaction was positively related to insomnia severity , especially among women.
CONCLUSIONS : CBT holds promise as an effective approach for persons with SCI experiencing depression , anxiety , adjustment , and coping problems.
CONCLUSIONS : CCCTC-binding factor and SP1 cross talk may contribute to homocysteine-reduced hTERT DNA methylation and expression in endothelial senescence.
CONCLUSIONS : CD4 + lymphocyte counts were associated with AMH in both HIV-infected and uninfected women.
CONCLUSIONS : CDST can significantly improve spatial cognition in a rat model of AD.
CONCLUSIONS : Cell therapy is an efficient procedure for reconstructing degenerative entheses.
CONCLUSIONS : Cementodentinal or cemental tears are unique , localized , tooth-related factors associated with attachment loss.
CONCLUSIONS : central obesity was associated with IMCL and EMCL infiltration and IR.
CONCLUSIONS : Ceramic primer in combination with self-adhesive resin composite cement demonstrated a positive effect on SBS to zirconia and should be used for cementation.
Conclusions : Cerebral WMH should be considered along with conditions affecting mobility from other systems when considering risk and treatment for mobility limitations.
CONCLUSIONS : Cerebral WM showed accelerated aging in SCZ but not in MDD , suggesting some difference in the pathophysiology underlying their WM aging changes.
CONCLUSIONS : Certain aspects of both physical and social QOL worsened over time.
CONCLUSIONS : Certain dyadic characteristics and treatment-related factors were associated with treatment failure including financial strain and lack of strategy integration.
CONCLUSIONS : CFBA relates closely anatomically with recurrent laryngeal nerve and thyroid grand.
CONCLUSIONS : CFC is featured as complex syndromes.
CONCLUSIONS : CFPD during childhood is associated with an increased risk for dementia in men who survived until old age.
CONCLUSIONS : CGA performed at the beginning of hospitalisation in acute medical wards is useful to predict institutionalisation.
CONCLUSIONS : CGGn on FMR1 already at young ages affects FOR , but is clinically apparent only in cases of PDFOR.
CONCLUSIONS : Change in d / a is considered to be an index of change in TPR.
CONCLUSIONS : Changes in L-BMD in the monthly minodronate and weekly alendronate groups are generally comparable.
Conclusions : Changes in the gut metagenome are associated longitudinally with cognitive function and brain iron deposition.
CONCLUSIONS : Changes in the parameters describing body posture throughout consecutive decades were observed.
CONCLUSIONS : Childhood adversity may cause biological or psychological vulnerability , which is associated with both depressive symptoms and cognitive decline in later life.
CONCLUSIONS : Childhood cancer survivors , in particular long-term survivors , have a poor adherence to the US dietary guidelines.
CONCLUSIONS : Childhood TBI is associated with psychosocial problems in adulthood , regardless of injury severity.
CONCLUSIONS : Childhood trauma is associated with short LTL in individuals with PTSD.
CONCLUSIONS : Children with kwashiorkor were metabolically distinct from those with marasmus , and were more prone to severe metabolic disruptions.
CONCLUSIONS : Cholecystectomy should be recommended to elderly patients after a first acute biliary complication.
CONCLUSIONS : Choroidal morphologic features are generally comparable between children and adults.
CONCLUSIONS : Chronic conditions impact greatly on quality of life and disability in the older Spanish population , especially when co-occurring diseases are added.
CONCLUSIONS : Chronic daily consumption of flavanone-rich @percent@ orange juice over @number@ wk is beneficial for cognitive function in healthy older adults.
CONCLUSIONS : Chronic disease burden increases risk of MCI , whereas certain lifestyle factors reduce risk in persons @number@ years and older.
Conclusions : Chronic shift work causes night shift intolerance , which is probably linked to the degraded plasticity of the circadian control system.
CONCLUSIONS : Chronic symptoms , characterized by both trouble maintaining and initiating sleep , are patterned by social factors.
CONCLUSIONS : Chronic uremia appears as a state of \ "carbonyl stress \ " targeting several different plasma proteins.
CONCLUSIONS : Circadian rhythms at the beginning of the treatment are good predictors of future weight loss.
CONCLUSION ( S ) : Circulating AMH concentrations decline with increasing reproductive age in a manner optimally described by a quadratic equation.
CONCLUSIONS : Circulating concentrations of lysine , tyrosine , and valine were independently and positively associated with GDM through modifying insulin resistance and secretion.
CONCLUSIONS : Circulating DKK-1 is increased in T2DM and associated with endothelial dysfunction and platelet activation.
CONCLUSIONS : Circulating inflammatory markers are weakly associated with MR-visible PVS , but not directly with WMH.
CONCLUSIONS : CKD-EPI-based estimates of eGFR outperformed MDRD-based estimates of eGFR and CG-based estimates of eCCr as a predictor of hADRs.
CONCLUSIONS : CKD is prevalent among older adults in Germany , but awareness is low.
CONCLUSIONS : CKD patients have an altered night-time pressure profile and higher PP that translate into a more severe cardiac organ damage.
CONCLUSIONS : Claims data alone can be used to classify individuals as frail and nonfrail.
CONCLUSIONS : Clinical discrimination of the early stages of AD and MCI is challenging.
CONCLUSIONS : Clinical features differentially impact outcomes with poorer function associated with all types of costs and caregiving received.
CONCLUSIONS : Clinical features in sporadic nfvPPA caused by FTLD subtypes relate to neurodegeneration of GM and WM in frontal motor speech and language networks.
CONCLUSIONS : Clinical interpretation of aerobic capacity impairment is influenced by aging in HF patients.
Conclusions : Clinical trials targeting aging are feasible , but require careful design consideration and monitoring rules.
CONCLUSIONS : Clinicians ' recruitment and questionnaire completion rates support the feasibility of the planned RCT.
CONCLUSIONS : Clinicians should consider adopting these centiles when assessing acutely unwell children.
CONCLUSIONS : Clinicians should exercise caution in assessing sleep quality in inpatient settings.
Conclusions : Cluster analysis reveals statistically significant groups of test locations within the 30-2 test grid exhibiting the same age-related decline.
CONCLUSIONS : CMR parameters that have been associated with myocardial fibrosis were related to older age in the MESA study.
CONCLUSIONS : COACH participants were twice as likely to use the COACH intervention as RealAge participants were to use the RealAge intervention.
CONCLUSIONS : Cognitive and functional performances are predictors of survival in centenarians.
CONCLUSIONS : Cognitive-based training is effective for the healthy older people.
CONCLUSIONS : Cognitive complaints are related to conversion among nondemented older adults.
CONCLUSIONS : Cognitive declines appear to precede and cause functional declines prior to and following dementia diagnosis.
CONCLUSIONS : Cognitive dysfunction in late-life BD does not appear to be due primarily to processes related to increased WMH or reduced gray matter volume.
CONCLUSIONS : Cognitive function explains a significant proportion of the associations between health literacy , physical health , and depression among older adults.
CONCLUSIONS : Cognitive impairment in patients with confluent WML is mediated by global and frontal cortical atrophy.
CONCLUSIONS : Cognitively intact and cognitively impaired patients have similar outcomes post-TCP.
CONCLUSIONS : Cohort effects detected using the proposed method agree well with previous descriptive epidemiologic findings.
CONCLUSIONS : Cohort effects were observed in all examined cognitive domains and , surprisingly , remained significant after controlling for educational effects.
CONCLUSIONS : Collaboration with the ICT was helpful for detection of pathogenic bacteria and allowed appropriate use of antibiotics at an early stage.
CONCLUSIONS : Colon EMR is safe and effective in elderly patients.
CONCLUSIONS : Colonic diverticulosis and diverticular bleeding are prevalent and increasing in Japan.
CONCLUSIONS : Columella soft-tissue is remarkable for the presence of fibroblasts , collagen and elastin fibers , muscle fibers , and adipocytes.
CONCLUSIONS : Combined information on LV end-diastolic dimension and heart rhythm at diagnosis is useful in predicting future LVRR in patients with IDC.
CONCLUSIONS : Combined treatment with testosterone plus dutasteride reduces prostate volume and prostate specific antigen compared to testosterone only.
CONCLUSIONS : Combined unhealthy weight was comparable in urban and rural India.
CONCLUSIONS : Combining an anti-CD20 antibody with chemotherapy improved outcomes in patients with CLL and coexisting conditions.
CONCLUSIONS : Common genetic risk factors have a small but consistent association with AAO in PD.
CONCLUSIONS : Common genetic variants with large impact on prostate cancer survival were not observed in this study.
CONCLUSIONS : Common methods and shared standards between laboratories would improve the interpretation of RBC storage measurements.
CONCLUSIONS : Common , severe mortality-associated diseases are less prevalent among LLFS probands and their offspring than in the general population of aging Americans.
CONCLUSIONS : Common variants in TMEM106B serve as a distinct risk factor for TDP-43 pathology in older persons without FTLD.
CONCLUSIONS : ' Communicate ' and ' manage ' activities are widely used in care coordination.
CONCLUSIONS : Communities with the most exceptional aging have low ambient air pollution and low rates of smoking , poverty , and obesity.
CONCLUSIONS : Community resources are integral in facilitating the development of older people's individual resources , and opportunities and capabilities for participation.
CONCLUSIONS : Comorbid conditions in conjunction with aging can reduce fracture HR.
CONCLUSIONS : Comorbidities are prevalent among PLWH and add substantially to treatment costs for PLWH.
CONCLUSIONS : Comorbidity , age , or more progressed osteoarthritis should not be considered an impediment to knee replacement.
CONCLUSIONS : Comorbidity does not fully explain the relationship between the mGPS and cancer-specific survival in CRC patients.
CONCLUSIONS : Comorbidity of AUDs and CUDs was evident from youth through adulthood but the strength of the relationship lessened in adulthood.
CONCLUSIONS : Companies provide a suitable setting for screening for prediabetes.
CONCLUSIONS : Comparable prevalence estimates are urgently needed for realistic description of the magnitude of the problem of multimorbidity.
CONCLUSIONS : Compared with family medicine physicians , radiologists had non significant higher risk of cancer hospitalizations.
CONCLUSIONS : Compared with patients without frailty , patients with mild , moderate , and severe frailty had significantly increased odds of developing postoperative complications.
CONCLUSIONS : compared with SMT , NIV decreased the rate of meeting the ETI criteria and the mortality rate of very old patients with AHRF.
CONCLUSIONS : Compared with the general population , people with ID show higher healthcare utilisation in younger age groups.
CONCLUSIONS : Completing an LDCW is strongly associated with lower 10-year mortality and HF risk in older adults.
CONCLUSIONS : Complex profiles were observed for endocrine and special chemistry markers , requiring establishment of age- and gender-specific reference intervals.
CONCLUSIONS : Compliance did not depend on smoking-related characteristics.
CONCLUSIONS : Compliance was better for FDCT than the other therapeutic regimens in the study population.
CONCLUSIONS : Components of an adverse lifestyle were associated with high CRP levels.
CONCLUSIONS : Computer-aided regional abdominal fat quantification is a reliable computational tool for large-scale epidemiological studies.
CONCLUSIONS : Conceptualizing neurocognitive challenges through a disability lens focuses attention on how impairments interact with other realities in these women's lives.
CONCLUSIONS : Concern about falling was highly prevalent in our sample of community-living older women.
CONCLUSIONS : Concerning longevity in Chinese , there is an association between BMI and cognitive function.
CONCLUSIONS : Conclusions from these data must be considered to be preliminary and need to be replicated.
CONCLUSIONS : Conditional exclusion shows an age-related pattern of impairment distinct from inhibition and abstraction.
CONCLUSIONS : Conducting plate waste research in QSRs is feasible and there is concordance with stated calorie information.
CONCLUSIONS : Confirming the hypothesis , increased synovial levels of aggrecan , bFGF , BMP-7 , and CD105 were found in patients over @number@ years.
CONCLUSIONS : Consistent with clinical imaging observations , geographic atrophy was associated with choroidal thinning.
CONCLUSIONS : Constipation increased the risk of urinary incontinence in subjects , and increase in dietary monounsaturated fat and plasma triglyceride levels decreased the risk.
CONCLUSIONS : Consumption of alcohol , caffeine , fiber , and fish-derived PUFAs was not significantly associated with AF risk.
CONCLUSIONS : Consumption of nuts and seeds accounts for meaningful decreases in biologic aging and cell senescence.
CONCLUSIONS : Contact lens wearers harbor Demodex as frequently as nonwearers and in higher numbers , which is best detected using in vivo confocal microscopy.
CONCLUSIONS : Contrary to affluent modern-day populations , APOE-ε4 did not carry a survival disadvantage in this rural Ghanaian population.
CONCLUSIONS : Contrary to expectations , TTC exercise did not specifically improve cognition or physical mobility.
CONCLUSIONS : Contrast sensitivity is reduced in HIV-infected individuals and functionally associated with frailty and unsuppressed viraemia.
CONCLUSIONS : Control expectancy , self-efficacy , and social influence mediate the relationship between SES and dietary habits.
CONCLUSIONS : Coordinated changes in gene transcription cascades underlie changes in synaptic , neurotrophic , and inflammatory phenotypic networks during brain Development and Aging.
Conclusions : COPD is a highly prevalent disease in China and its importance is growing steadily.
CONCLUSIONS : Corneal blindness is a public health problem in southern Harbin , the majority of which is either preventable or treatable.
CONCLUSIONS : Corneal confocal microscopy allows a non-invasive examination of the living cornea , analyzing the microstructure of each corneal layer.
CONCLUSIONS : Corneal shapes were influenced by age and MA in the Hong Kong Chinese.
CONCLUSIONS : Correct understanding of vitreoretinal anatomic and functional changes due to posterior vitreous detachment is essential for a proper diagnosis and treatment.
CONCLUSIONS : Cost estimates did not differ significantly between CN and MCI.
CONCLUSIONS : Costs of Alzheimer's disease are high across European countries.
CONCLUSIONS : Cough has a high prevalence and is detrimental to quality of life in the elderly.
CONCLUSIONS : Coworker social support is an important correlate of physical activity and should be incorporated in workplace health promotion programs.
CONCLUSIONS : CPAP therapy with good adherence is related directly and indirectly to a better intimate relationship with bed partner in men with OSA.
CONCLUSIONS : CpG island methylator phenotype was not associated with CRC prognosis after adjusting for other important clinical factors and associated mutations.
CONCLUSIONS : CPIS , procalcitonin , and C-reactive protein are reliable for the diagnosis of NHAP.
CONCLUSIONS : CR correlates are implemented in different anatomic WM areas in HE and patients with a-MCI.
CONCLUSIONS : CRC patients are at increased long-term risk for unemployment , especially among rectal cancer and younger patients.
CONCLUSION : Screening and assessment of nutritional status and prevention interventions should be considered in SHA settings.
CONCLUSIONS : CRF and VFA are key determinants of the circulating FGF21 concentration.
CONCLUSIONS : CRF is inversely related to the prevalence of gallbladder disease among relatively healthy men and women in the ACLS cohort.
CONCLUSIONS : CRF is positively associated with executive function and episodic memory in OA and attenuates age-related cognitive decline.
CONCLUSIONS : Cross-sectional analysis found a positive association of HDL-C with age while controlling for triglycerides.
CONCLUSIONS : Crowding fluctuates consistent with routine activities such as meals in long-term care settings.
CONCLUSIONS : CRP remains an important prognostic biomarker in the management of known malignancies.
CONCLUSIONS : CRT results in a significant improvement in libido and erectile function in patients with congestive HF.
CONCLUSIONS : CSF evidence of preclinical AD in patients with subjective complaints predicted cognitive decline over time , encompassing more than memory alone.
CONCLUSIONS : CSF miRNAs can discriminate AD from controls.
CONCLUSIONS : CTC has a high sensitivity and negative predictive value in excluding a CRC in patients with colorectal symptoms.
CONCLUSIONS : CT scan should be the first choice of non-invasive examination for cystic pancreatic diagnosis.
Conclusions : Culturally and linguistically isolated populations like Chinese older women are at risk of exclusion from advancements in precision medicine.
CONCLUSIONS : Cumulative burden of cardiovascular risk factors from childhood / adolescence associate with worse midlife cognitive performance independent of adulthood exposure.
Conclusions Cumulative occupational mechanical exposures during working life - such as lifting and kneeling work - increased the risk of LTSA.
CONCLUSIONS : Current , but not past , depression is associated with increased mortality , and this excess mortality is strongly associated with frailty.
CONCLUSIONS : Current MUI definitions do not adequately categorize clinically relevant UI subgroups.
CONCLUSIONS : Current practices in some clerkships are inadequate to prepare medical students to care for older patients with psychiatric symptoms.
CONCLUSIONS : Cyanosis and lymphocytosis are independent predictors for pertussis in children up to @number@ months old.
Conclusions : Cystatin C eGFR was linearly related to poorer physical performance beyond middle age among community-dwelling adults.
CONCLUSIONS : Cytokeratin-positive hepatic progenitor cells are likely to exist along the hilar portal pedicle even in adults.
CONCLUSIONS : Cytotoxicity of all tested denture base materials increased significantly after the long-term aging.
CONCLUSIONS : Daily magnesium oxide supplementation for @number@ wk seems to improve physical performance in healthy elderly women.
CONCLUSIONS : Daily tea consumption is associated with a lower likelihood of depressive symptoms in Chinese older people living in a rural community.
CONCLUSIONS : Daily time spent being sedentary is positively associated with predicted 10-year HCHD risk among mobility-limited older adults.
CONCLUSIONS : DAL residents with dementia had a hospitalization rate almost 4-fold higher than LTC residents with dementia.
CONCLUSIONS : Dance therapy modulates selected hematological parameters of older women ; it leads to increase in erythrocyte count and hematocrit level.
CONCLUSIONS : Data from this study demonstrate that topical anesthetic for facial rejuvenation can be enhanced with laser pretreatment while maintaining safe blood serum levels.
CONCLUSIONS : Data indicate that precuneus neurotrophin pathways are resilient to amyloid toxicity during the onset of AD.
CONCLUSIONS : Data suggest that hormonal fluctuations ( especially during menopause ) may increase the tendency to develop BPPV.
CONCLUSIONS : Data support previous work showing lower GRF , stride length , and velocity in old runners.
CONCLUSIONS : Decline in older persons ' speech-in-noise recognition over time accelerated for older ages.
CONCLUSIONS : Declines in MD with increasing age are present premenopausally , continue postmenopausally , and are most pronounced over the menopausal transition.
CONCLUSIONS : Declines in self-esteem represent a mechanism that contributes to higher levels of diurnal cortisol secretion if older adults experience psychological distress.
CONCLUSIONS : Decreased GFR was highly prevalent among the geriatric population in a megalopolis of a developing country.
CONCLUSIONS : Decreased hospital-wide nurse staffing levels are associated with increased in-hospital mortality among patients admitted with hip fractures.
CONCLUSIONS : Decreased levels of TGF β in Alzheimer's disease may result in impairment of cerebral circulation reflected in the increased endoglin levels.
CONCLUSIONS : Deferoxamine infusion improved cerebrovascular function , particularly in older individuals.
CONCLUSIONS : Delirium in the ED is not a transient event and frequently persists into hospitalization.
CONCLUSIONS : Delirium symptoms are independent predictors of one-year mortality in hospitalized patients with severe pneumonia.
CONCLUSIONS : Dementia ( all etiologies ) is not predictive of mortality.
CONCLUSIONS : Dementia and depression are common in community-dwelling older Americans , and hospitalization is associated with these conditions.
CONCLUSIONS : Demographic changes mean that dementia will represent a significant problem in the future.
Conclusions : Dendritic cells increase in the entire cornea of MCGP , with a higher density at limbus.
CONCLUSIONS : Depressed patients are impaired in most domains of frontal lobe related cognitive functions.
CONCLUSIONS : Depression has the strongest influence on suicidal ideation and attempts.
CONCLUSIONS : Depression is highly prevalent in adults with tuberculosis , and is associated with worse health status compared to tuberculosis without depression.
CONCLUSIONS : Depression , particularly mild depression , is common in this rural population of older adults , particularly among women and widowed elderly.
CONCLUSIONS : Depression screening is indicated in patients with acute coronary syndrome with sleep disturbance.
CONCLUSIONS : Depressive symptoms were associated with all-cause mortality in men and with suicide in both sexes.
CONCLUSIONS : Derivation of robust treatment recommendations for peri-implantitis requires more comprehensive and patient-centred evidence on peri-implantitis treatments.
CONCLUSIONS : Designing age-friendly neighbourhoods might slow or delay age-related declines in WfT and should be a priority.
CONCLUSIONS : Despite a high arthroplasty survival rate and good long-term clinical results , RTSA outcomes showed deterioration when compared with medium-term results.
CONCLUSIONS : Despite a tendency to overeat , patients with bvFTD have a hormonal profile that should decrease food intake.
CONCLUSIONS : Despite claims of safety , Bio-Alcamid and possibly other soft-tissue fillers available worldwide have the potential to cause adverse reactions.
CONCLUSIONS : Despite diverse sociodemographic circumstances and challenges in the healthcare system , all women successfully navigated the triple barriers.
CONCLUSIONS : Despite HAART , pulmonary structural and functional abnormalities are frequent in HIV-positive patients.
CONCLUSIONS : Despite high education levels , young adults in our study had a worse understanding of POP compared to UI or ED.
CONCLUSIONS : Despite impacting taste intensity , the addition of barium to liquid stimuli does not appear to alter behavioral parameters of swallowing.
CONCLUSIONS : Despite improved survival , HIV-infected adults on suppressive ART have diminished physical function compared to HIV-uninfected persons.
CONCLUSIONS : Despite persistent control of plasma viremia , these older HIV-infected participants demonstrate more rapid progressive brain atrophy when compared with healthy aging.
CONCLUSIONS : Despite shared values of the importance of family and family caregiving , concrete ideas about caregiving differed considerably.
CONCLUSIONS : Despite the reduced maximum isometric torque and muscle strength , the results suggest small variations of ankle muscle synergies during the aging process.
CONCLUSIONS : Despite the rising prevalence of vascular risk factors , improved adherence to stroke performance measures was accompanied by better stroke outcomes.
CONCLUSIONS : Despite the strong preclinical evidence of positive cardiometabolic effects , studies to date have not confirmed resveratrol's benefit in humans.
CONCLUSIONS : Detriments in health-related quality of life persist over more than a decade and affect predominantly younger patients.
CONCLUSIONS : Developing an LLI was associated with a cessation in alcohol consumption and a reduction in consumption to special occasion drinking from early adulthood.
CONCLUSIONS : Developmental plasticity impacts much of human growth.
CONCLUSIONS : Dexmedetomidine-based sedation resulted in achievement of early extubation more frequently than propofol-based sedation.
CONCLUSIONS : DHEA supplementation may significantly improve IVF outcomes in infertile women with advanced reproductive age and normal ovarian reserve.
CONCLUSIONS : Diabetes differentially affects self-rated overall health and depression by age , with convergence in the oldest age-group with and without diabetes.
CONCLUSIONS : Diabetes is associated with higher risk of institutionalization even after adjusting for complications.
CONCLUSIONS : Diabetes is associated with increased risk of ischemic stroke although it declines with age though at lower rate among women than men.
CONCLUSIONS : Diabetes-related distress , initial and titration of insulin dose , and age all significantly predict insulin-associated weight gain.
CONCLUSIONS : Diabetes self-management programmes for older adults demonstrate a small reduction in HbA ( 1c ) , lipids and blood pressure.
CONCLUSIONS : Dichotomizing hospice users only into nursing home vs. non-nursing home patients is difficult , due to transitions across settings.
CONCLUSIONS : Dietary fiber intake was independently associated with better physical performance.
CONCLUSIONS : Dietary guidelines for CVD risk reduction may also benefit bone health in this Hispanic cohort.
CONCLUSIONS : Dietary habits with high TAC showed a stronger inverse association with frailty in elderly Japanese women than the individual foods examined.
CONCLUSIONS : Dietary patterns correlate with cognitive function in Taiwanese aged @number@ years and older and can predict the occurrence of subsequent cognitive decline.
CONCLUSIONS : Dietary supplements , including non-prescribed supplements , were commonly used by people attending memory clinics.
CONCLUSIONS : Differences exist between patients and caregivers ' perceptions about subjective states.
CONCLUSIONS : Differences exist in driving patterns of older and younger drivers as measured by reaction times and driving simulator outcomes.
CONCLUSIONS : Differences in prevalence rates of prefrailty and frailty should be minimized , with stimulus for standardization for the evaluation of human frailty.
CONCLUSIONS : Different approach among geographical areas and intervention programs for identified cultural groups and their providers are warranted to improve disparities in diabetes care.
CONCLUSIONS : Different BZDs may vary in their propensity to predispose to falls , with diazepam having the strongest association.
CONCLUSIONS : Different core materials and self-adhesive resin cements can significantly affect bond durability of zirconia ceramic. .
CONCLUSIONS : Different demographic and caregiving factors were associated with caregiver involvement in various medication management activities.
CONCLUSIONS : Different manifestations of hypoalgesia between aerobic and isometric exercises were found.
CONCLUSIONS : Different site-age combinations show significant variation of skin surface roughness.
CONCLUSIONS : Digital maps of quantitative AF , cell density , and packing geometry provide metrics for cellular-resolution clinical imaging and model systems.
CONCLUSIONS : Diluted CaHA improved skin elasticity and increased dermal thickness in the upper arms and abdomen after only a single treatment.
CONCLUSIONS : Direct assays for both LDL-C and HDL-C provide an acceptable guide for lipid treatment.
CONCLUSIONS : Disability free lifetime and its development over time are important topics in public health.
CONCLUSIONS : Disability , social support , religiosity , and personality strongly influence morale in the elderly.
CONCLUSIONS : Discordance between current preferences and POLST orders is complex.
CONCLUSIONS : Discrepancies between ERPs and TF results challenge conclusions made about age-related changes in Go / NoGo-N2.
CONCLUSIONS : Discrepancies between the reports of children / adolescents and their proxy respondents were observed.
CONCLUSIONS : Discrimination is far more prevalent among Chinese than among whites and may explain their disproportionate exposure to other hazards.
CONCLUSIONS : DISH was less prevalent in women but affected almost one-quarter of older white men.
CONCLUSIONS : DIS , IDHAS , and no confirmable syndrome typing were dominant in asymptomatic HIV infection patients.
CONCLUSIONS : Disparities in incidence persist despite ongoing TB control efforts.
CONCLUSIONS : Dispositional optimism is correlated to lower feelings of loneliness over time in older men , independently of depression or changes in social network.
CONCLUSIONS : Distinct gender and age differences were found in the incidence of I-VA according to their site of origin.
CONCLUSIONS : Dizziness in older age was predicted by multiple factors.
CONCLUSIONS : DLVOTO develops from various reasons , and patients with prominent PMs have distinct characteristics.
CONCLUSIONS : Dose-effect relations for myocardial metabolic disorders tended to be observed.
CONCLUSIONS : Double-echo chemical shift gradient-echo magnetic resonance imaging is useful for quantifying pancreatic fat fraction.
CONCLUSIONS : Drift in electrode position during a session of tDCS produces significant alteration in the intensity of stimulation delivered to the brain.
CONCLUSIONS : DSG was effective and generally well tolerated in adults regardless of age.
CONCLUSIONS : DSST score and serum cystatin C warrant priority consideration for the evaluation of mortality risk in older individuals.
CONCLUSIONS : Dual targeting of VEGF and Ang2 can potentiate the effectiveness of VEGF inhibitors and avoid the formation of empty BMS.
CONCLUSIONS : Due to competing lifestyle demands , exercise intensity may be less of a factor in adherence among older women than is exercise duration.
CONCLUSIONS : During 2005-2011 , there was an @percent@ increase in the proportion of elderly ICU patients.
CONCLUSIONS : During aging , the lower lumbar spine retains its lordosis and mobility , whereas the middle part flattens and becomes less mobile.
CONCLUSIONS : During extreme heat and humidity , fan use elevates physiological strain in aged , but not young , adults.
CONCLUSIONS : During storage , RBCs develop an increased susceptibility to stress-induced loss of phospholipid asymmetry that is especially associated with an aging phenotype.
CONCLUSIONS : During their life , endothelial cells impair the ability to defend themselves from oxidative stress stimuli.
CONCLUSIONS : dVRS are always detected in the BG or WM in elderly people , and large dVRS are also prevalent.
CONCLUSIONS : DXA underestimates the age-related loss of thigh muscle mass in comparison to MRI.
CONCLUSIONS : Dyadic relational resources may moderate the effects of role strain.
CONCLUSIONS : Dynamic cerebral autoregulation is impaired in the early days after SAH.
Conclusions : Dynapenic abdominal obese participants are at higher risk of worsening disability and hospitalization than ND / NAO participants.
CONCLUSIONS : Dysfunctional ToM is a prominent feature of the cognitive profile of ALS.
CONCLUSIONS : E-64 was effective on inhibiting cathepsins activity in dentin , and induced less collagens degradation in smear layer for better dentin-resin bond durability.
CONCLUSIONS : EA in African Americans is strongly associated with higher RMR.
CONCLUSIONS : Ear body temperature is lower than traditionally reported and differs with age and sex.
CONCLUSIONS : Early AFB is possibly related to CVD.
CONCLUSIONS : Early age at surgical menopause was associated with cognitive decline and AD neuropathology.
CONCLUSIONS : Early resuscitation should be initiated for the prevention of shock in adult patients with HPVG in the ED.
CONCLUSIONS : East Asian variant ALDH2 2 genotypes and , hence , deficient ALDH2 activity were associated with CSA in Japanese.
CONCLUSIONS : Eating alone was a key risk factor for depressive symptoms in community-dwelling older adults.
CONCLUSIONS : Eating-with-others is an independent survival factor in older men.
CONCLUSIONS : E-cig aerosols have variable nicotyrine quantities.
CONCLUSIONS : E-cigarette expenditures might be a more useful measure of intensity of e-cigarette use.
CONCLUSIONS : ED frequent attenders in Singapore were associated with higher age and presence of multiple comorbidities rather than with social causes of ED use.
CONCLUSIONS : ED is related to impaired vasodilation , reduced relaxant capacity , and diminished cGMP content in penile tissue.
CONCLUSIONS : Educational attainment is a significant predictor of longevity.
CONCLUSIONS : Education and employment were important drivers of these measured inequalities.
CONCLUSIONS : Education levels may affect the benefits of booster counselling sessions on smoking cessation among Chinese smokers.
CONCLUSIONS : EEG inter- and intra-hemispheric functional connectivity in neonates during sleep changes with the CA and CRA in delta and beta bands.
CONCLUSIONS : EEG is associated with subclinical WML burden and cortical brain atrophy in a memory clinic population.
CONCLUSIONS : EFAT2 showed concurrent validity with the Barthel Index when used to assess the effects of rehabilitation on participants with advanced cancer.
CONCLUSIONS : Effective interventions in diet , medications , biochemical exposures , psychological condition , pre-existing disease and lifestyle may decrease new incidence of AD.
CONCLUSIONS : Effects of strength reduction occurring during a period of hospitalization could produce effects even after hospitalization itself.
CONCLUSIONS : Efforts are needed to improve AI / ANs access to these services.
CONCLUSIONS : eGFR is likely to overestimate the renal function of elderly cancer patients.
CONCLUSIONS : EHR data can be used to identify complex phenotypes such as harmful alcohol use.
CONCLUSIONS : Eight established risk loci were associated with progression to PCSM after diagnosis.
CONCLUSIONS : Elderly AML patients carry dismal prognosis with their final phase of disease mostly hospitalized in acute care settings.
CONCLUSIONS : Elderly AML patients had better outcomes with intensive chemotherapy than with low-intensity chemotherapy.
CONCLUSIONS : Elderly individuals classified as high response experienced greater creatine kinase and interleukin-6 responses to ERE.
CONCLUSIONS : Elderly Mex have a different body composition compared with AA and Cauc of a similar BMI and age.
CONCLUSIONS : Elderly patients with CU had a higher prevalence of AD.
CONCLUSIONS : Elderly subjects treated with laxatives were twice as likely to fall compared with non-laxative users.
CONCLUSIONS : Elder mistreatment is prevalent among U.S. Chinese older adults regardless of the definitional criteria.
CONCLUSION : Selected diabetes risk factors and risk scores are associated with subsequent frailty.
CONCLUSION : Selection of dermal filler with the right rheological properties is a key factor in achieving a natural-looking long-lasting desired aesthetic outcome.
CONCLUSIONS : Elective upper GI endoscopy after @number@ hours fasting for clear liquids was more comfortable and equally safe compared to conventional fasting.
CONCLUSIONS : Electrodes inserted during deep brain stimulation surgery are tethered at the point of entry to the skull.
CONCLUSIONS : Elevated DepE scores are associated with poor neuropsychological performance among cognitively normal older adults.
CONCLUSIONS : Elevated levels of tocopherol and tocotrienol forms are associated with reduced risk of cognitive impairment in older adults.
CONCLUSIONS : Elevated N-terminal pro-B-type natriuretic peptide and troponin T are associated with rapid decline of kidney function and incident CKD.
CONCLUSIONS : Elevated plasma esRAGE is independently associated with CKD and is an independent predictor of incident CKD in older community-dwelling adults.
CONCLUSIONS : Elevated PTH concentrations are associated with a five-year cognitive decline in a general aged population , independently of Ca2 + and renal function.
CONCLUSIONS : Elevated serum FGF21 levels may be a useful biomarker for predicting kidney disease progression , especially in the early stages of diabetic nephropathy.
CONCLUSIONS : elevated triglyceride levels increased the risk for HIV-sensory neuropathy in HIV-positive individuals independently of other known risk factors.
CONCLUSION : Self-assessed severity of constipation increased but quality of life remained stable in a cohort of people with SCI followed prospectively for @number@ years.
CONCLUSION : Self-awareness of memory function is relatively well preserved in PD , but is negatively affected by depressive symptoms.
CONCLUSION : Self-neglect is associated with lower global cognitive function , episodic memory and perceptual speed.
CONCLUSION : Self-rated health is high in this sample considering the number of comorbidities.
CONCLUSION : Self-reported MD , chiefly when due to uncorrected edentulism , is associated with 9-year all-cause mortality in community-dwelling elderly adults.
CONCLUSION : Self-reported memory failure predicted future dementia or AD independent of objective memory performance.
CONCLUSION : Self-reported sleep duration was associated with 7-year mortality in this cohort of older adults , even when adjusted for health status.
CONCLUSION : Self-reported sleep problems may increase the risk for dementia , and depressive symptoms may explain this relationship.
CONCLUSION : Self-reported values correlated well with technician measured values and average discrepancies were small.
CONCLUSION : Self-report of executive functioning difficulties may be a useful prognostic indicator for subsequent speed of response to antidepressant medication.
CONCLUSION : Semiquantitative elastography shows that pancreata become significantly harder during aging , but remain softer than in chronic pancreatitis.
CONCLUSIONS : Emotional support may increase well-being among Spanish-speaking Latina cancer survivors by reducing cancer fatalism.Copyright © @number@ John Wiley & Sons , Ltd.
CONCLUSIONS : Empirical titration is recommended for accurate determination of ST in patients receiving RUL-UB ECT.
CONCLUSIONS : Employing MPLSM , dermal changes occurring in photo-aged human skin were visualized in an unprecedented manner and correlated to a loss of firmness.
CONCLUSIONS : Employing strategies that address health barriers to participation could improve attendance rates for group-based exercise programs.
CONCLUSIONS : Employment status showed varying impacts on obesity by age and gender.
CONCLUSIONS : Endogen E2 , and , consequently , its decline during menopausal transition , is not a determinant factor for OS.
CONCLUSIONS : Endothelial cell damage and glycocalyx shedding are associated with worse flow , density , and heterogeneity within microvessels after traumatic hemorrhagic shock.
CONCLUSIONS : Endovascular therapy is now standard of care for eligible patients with anterior large vessel occlusions.
CONCLUSIONS : Endovascular treatment of mesenteric ischemia is a safe and effective therapy with acceptable long-term results.
CONCLUSIONS : Energy contributed by snacks and diet quality were affected by the strategy that an individual used to cope with stress.
CONCLUSIONS : Engagement in paid work may help maintain health in later life , although mechanisms and contextual influences need further investigation.
CONCLUSIONS : Enhancement of the economic status of families , especially poor families , is a prerequisite to the amelioration of anemia among adolescent girls.
CONCLUSIONS : Environmental epidemiology informing disease prevention will continue to be valuable.
CONCLUSIONS : Epidemiological studies do not show an increase in GERD symptom prevalence with age.
CONCLUSIONS : Epigenetic changes with aging represent molecular mechanisms to explain the increased susceptibly of the prostate to develop cancer in older men.
CONCLUSIONS : Epiploic BF is a surgical technique that allows for distal revascularization and a simultaneous cover of the limb extremity.
CONCLUSIONS : Epiretinal membranes are associated with macular cysts , PVCs , LMHs , VMT , and visual impairment.
CONCLUSION : Septic arthritis must be considered as a differential diagnosis in all patients with joint pain , swelling and immobility.
CONCLUSION : Serious gaps persist in pain management particularly for older adults with the most severe chronic pain.
CONCLUSION : Seroprevalence of toxoplasmosis in immunosuppressed individuals is rarely reported in China and we presented a positive rate of @percent@ in cancer patients.
CONCLUSION : Sertraline had a slightly better outcome than venlafaxine on some of the secondary outcome measures , but not on the primary outcome measure.
CONCLUSION : Serum fetuin-A levels were strongly and independently associated with MetS and its components in community-dwelling Chinese adults.
CONCLUSION : Serum HA level has the potential to be useful for the diagnosis of the presence and severity of knee OA.
CONCLUSION : Serum IGF-1 is a partial mediator in the age-related decline of bone health in men as determined by calcaneal ultrasound.
CONCLUSION : Serum osteocalcin is associated with indices of obesity and HDL level in men.
CONCLUSION : Serum retinol and zinc levels were significantly lower among elderly with hearing loss involving the high frequencies.
CONCLUSION : Serum VEGF levels in AD patients with depression were higher than those without depression.
CONCLUSIONS : Erythrocyte lifespan is substantially reduced in subjects with a CF-LVAD , which was more pronounced in the presence of device thrombosis.
CONCLUSIONS : ESI > 3.7 g / day is associated with adverse cardiac remodeling and worse systolic strain and diastolic e ' velocity.
CONCLUSIONS : ESR2 polymorphisms affect risk for AD in women , and risk alleles vary by AIMs-defined ancestry and self-identified ethnicity.
CONCLUSIONS : Establishing a conclusive positive or negative association between BMD and SES proved to be difficult.
CONCLUSIONS : Estimated energy requirement and average protein requirement were clinically validated for prevention of nutritional decline and of impaired healing of deep pressure ulcers.
CONCLUSIONS : Estimates of MR-detectable WMH burden using a volumetric protocol designed for , analysis of clinical scans correlate strongly with gold standard measurements.
CONCLUSIONS : Estradiol was associated with quantitative measures of visceral fat and varies by menopausal status.
Conclusions : eT2DM is distinct from mT2DM and characterized by pancreas atrophy , ductal lesions , and amyloid deposition.
CONCLUSIONS : Eucommia ulmoides has been used as a source of traditional medicine and as a beneficial health food.
CONCLUSIONS : Even a few years of formal education contributes to cognitive reserve.
CONCLUSIONS : Even at low intensity , the aerobic exercise with BFR requires a greater cardiac work and decreases endothelial function.
CONCLUSIONS : Even into old age , higher BMI is associated with mobility limitation and poor performance.
CONCLUSIONS : Even moderate increases in 24h SBP promote arteriolar fragility of the cerebral white matter in a population aged @number@
CONCLUSIONS : Even though older patients had more risk factors , our data suggest that there was no difference in surgical management and outcome.
CONCLUSION : Several genetic and lifestyle indicators were considered as candidate markers of aging.
CONCLUSION : Several modifiable clinical and lifestyle risk factors were found to predict incident multimorbidity.
CONCLUSIONS : Evidence suggests that FA exercise can improve certain fall risk-related motor outcomes and reduce falls.
CONCLUSIONS : Evolving care delivery models should consider the high mortality in older adults after a non-ST-segment elevation myocardial infarction.
CONCLUSIONS : Excellent memory performance in late life does not guarantee protection against cognitive decline.
CONCLUSIONS : Except the Symptom domain of SGRQ , the others have a reliabile internal consistency and a good hierarchical structure.
CONCLUSIONS : Excess body fat may be harmful for physical functioning among elders with COPD.
CONCLUSIONS : excess weight is associated with increased service use and cost in elderly individuals , in particular in obese class ≥2 individuals.
CONCLUSION : Sex hormones and adipokines show specific interactions in the two genders and in different age-classes in a representative sample of adult healthy subjects.
CONCLUSIONS : Existing AHRS systems can be considered for use in clinical biomechanics under constrained conditions of use.
CONCLUSIONS : Exogenous melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers.
CONCLUSIONS : Experiencing everyday discrimination was associated with shortened telomere length among older black adults.
CONCLUSIONS : Experiment results proved the validity and applicability of the algorithm.
CONCLUSIONS : Experts appeared to identify with the popular baby boomer label , but not necessarily the accompanying stereotypes.
CONCLUSIONS : Exposure to AGEs reduces expression of cystatin C and affects its normal secretion in cultured RPE.
CONCLUSIONS : Exposure to ambient particles could cause a downregulation of microRNAs involved in processes related to PM exposure.
CONCLUSIONS : Exposure to general anesthesia for procedures at age ≥40 years was not associated with prevalent MCI in the elderly.
CONCLUSIONS : Exposure to maternal type @number@ diabetes did not seem to increase the risk of attention deficits in the adolescent offspring.
CONCLUSIONS : Expression levels of androgen- and estrogen signaling components and stem cell markers are powerful prognostic tools.
CONCLUSION : Sex-specific treatment approaches with lasers and energy-based devices should be used to best serve male cosmetic patients.
CONCLUSION : Sexual health declined while concomitant morbidities increased in European men as a function of age.
CONCLUSION : Sexuality among widows in later life includes continuity and change processes.
CONCLUSIONS : F2RL3 methylation is a strong predictor of mortality , including all-cause , cardiovascular , cancer and other mortality.
CONCLUSIONS : Face-lifts were performed for @number@ women with a mean age of @number@ years and @number@ men with a mean age of @number@ years.
CONCLUSIONS : Facial visual cues but not hair or clothing cues drive the link between perceived age and survival.
CONCLUSIONS : Fall and injury risk in the population studied is related inversely to Hip ( STR ) / AnkPRO .
CONCLUSIONS : Falls and in particular fear of falling are important barriers to older people gaining health benefits of walking and MVPA.
CONCLUSIONS : Family functioning was related to cognitive impairment among Chinese nonagenarians and centenarians.
CONCLUSIONS : Family socio-economic position and emotion regulation appeared as the top predictors of both BMI change and onset of overweight and obesity.
CONCLUSIONS : Faster gait speed and chair rise time , and greater physical activity were associated with greater QoL , independent of HIV-related mortality risk.
CONCLUSIONS : Faster HR is associated with proinflammatory state in elderly patients ; this association seems to be limited to women with higher BMI.
CONCLUSIONS : Fat distribution is associated with mortality over @number@ years of follow-up independent of overall fatness.
CONCLUSIONS : Fatigue could partly be explained by the extent of using mobility assistive devices and age.
CONCLUSIONS : FD-ASOCT provides blur-free imaging and precise measurement of the tear meniscus , which is consistent with clinical examinations.
CONCLUSIONS : FDR subjects exhibit an abnormal AT metabolism including increased glucose uptake prior to bed rest.
CONCLUSIONS : FDT is useful for monitoring functional damage in the SAP-normal hemifield in OAG eyes with low-to-normal IOP.
CONCLUSIONS : Female gender is associated with smaller aortic dimensions , but only at a young age.
CONCLUSIONS : Female sex , cognitive impairment and cystatin C were risk factors for falls in non-dependent institutionalized elderly people.
CONCLUSIONS : FFR-guided PCI is beneficial regardless of age , however , older patients have fewer functionally significant lesions , despite a similar angiographic appearance.
CONCLUSIONS : FGF @number@ gene SNP sites rs2973644 and rs10473352 polymorphisms may be associated with susceptibility to COPD in Han population of North China.
CONCLUSIONS : Fibrillar Aβ detected by [ ( @number@ ) C ] PiB-PET increases over time even in nondemented older adults.
CONCLUSIONS : Findings are discussed in relation to the functions of positive and negative social ties in suicidality.
CONCLUSIONS : Findings are discussed in the context of life span changes in social roles , normative personality development , and emotion regulation throughout adulthood.
CONCLUSIONS : Findings demonstrated a poor understanding of the physiology of overactive bladder and the rationale for various diagnostic modalities and treatments.
CONCLUSIONS : Findings from this study indicated that the prevalence of fractures among adult survivors did not increase compared with that of siblings.
CONCLUSIONS : Findings from this study indicate that older homeless veterans are at increased risk of serious medical problems.
CONCLUSIONS : Findings from this study provide information in addressing psychological burden at different times for different conditions.
CONCLUSIONS : Findings from this study support the use of the INQ-18 among community-dwelling older adults.
CONCLUSIONS : Findings from this work suggest that there are a number of significant processes that help people to deliver compassionate care.
CONCLUSIONS : Findings highlight the importance of cultural sensitivity when working with first-generation Chinese immigrants with diabetes.
CONCLUSIONS : Findings highlight the importance of making an accurate AD diagnosis to help reduce unnecessary treatment and increase appropriate therapy.
CONCLUSIONS : Findings highlight the importance of non-audiological factors in hearing rehabilitation to improve consultation for HI and hearing aid adoption.
CONCLUSIONS : Findings highlight the longitudinal impact of PTSD on increasing the incidence of cardiovascular disease in older adults.
CONCLUSIONS : Findings indicate that the oral health and OHRQoL of both pre-seniors and seniors in LTC residents is poor.
CONCLUSIONS : Findings indicate that the original AAS measures four distinct dimensions of anxiety about aging.
CONCLUSIONS : Findings suggest concerns about neuropsychological functioning that need to be more comprehensively assessed in adults with CHD.
Conclusions : Findings suggest differences in the rates of cognitive change by age , sex , education , and income.
CONCLUSIONS : Findings suggest that geographic region plays an important role in the sufficient use of mental health services among racial / ethnic minorities.
CONCLUSIONS : Findings suggest that older blacks may be particularly vulnerable to the effects of inadequate emotional support on vascular health.
CONCLUSIONS : Findings suggest that the relationship between alcohol consumption and cognition varies with gender.
CONCLUSIONS : Findings support consideration of persistent pain as a component of the frailty phenotype.
CONCLUSIONS : Findings underscore the need to clarify who may authorize an incapacitated adult's participation in research.
CONCLUSIONS : First- or second-line afatinib demonstrated preliminary activity and manageable safety in EGFR FISH-positive patients with advanced non-small-cell lung cancer.
CONCLUSIONS : FI severity improved with weight loss.
CONCLUSIONS : Fish consumption may protect against bone loss.
CONCLUSIONS : Fish-liver oil consumption , from early life , may reduce the risk of CHD in older women.
CONCLUSIONS : Five validated tools can be administered by nurses or non-professionals to screen for nutritional risk factors leading to unintentional weight loss.
CONCLUSIONS : Five-year survival estimates were higher in the US than in Germany overall , but the difference was only significant for ages 50-59 years.
CONCLUSIONS : Flexural strength and indirect tensile strength of resin composite cements are correlated.
CONCLUSIONS : FMR1 premutation seems to be an uncommon explanation for POF in Han Chinese.
CONCLUSIONS : Food insecurity-overweight and -obesity paradox appears not to be present in older men.
CONCLUSIONS : Foot posture and foot function were associated with the presence of specific foot disorders.
CONCLUSIONS : For adults living with SCI , good QOL is essential for successful rehabilitation.
CONCLUSIONS : For a @number@ year old lens an effect corresponding to elimination of @number@ years or more of optical ageing was obtained.
CONCLUSIONS : Forces well below the recommended value of @number@ N will cause significant compression / distortion of the airway in a child.
CONCLUSIONS : For CpG loci differentially methylated across subjects , methylation levels can be reliably assessed with one blood sample.
CONCLUSIONS : For facial wrinkle correction , large-particle calcium hydroxylapatite has a safety profile comparable with that of small-particle calcium hydroxylapatite.
CONCLUSIONS : For most biomarkers , biomarker progressions explained higher variability in cognitive decline than biomarker baseline values.
CONCLUSIONS : For older adults , chewing deficiency and lower social status were associated with lower compliance with dietary guidelines , independent of dietary knowledge.
CONCLUSIONS : for the fittest and at-risk HAAS participants , the accumulation of social deficits was associated with significant increases in mortality risk.
CONCLUSIONS : For the patients with cardiovascular disease , careful evaluation of surgical indication , perioperative management is required.
CONCLUSIONS : Four-megahertz dual RF wand delivery rejuvenation treatment produces a reduction in periorbital and midface rhytides.
CONCLUSIONS : Fractures in the elderly tend to be minimally displaced midfacial fractures that do not warrant surgical intervention.
Conclusions : Frailty among HIV-infected men was associated with increased inflammation and lower hormone levels , independent of comorbid conditions.
CONCLUSIONS : Frailty and mobility limitation are common among cardiac implantable electrical device patients and are correlated to device-detected physical activity.
CONCLUSIONS : Frailty before hip fracture is a predictor of greater post-fracture pain and deterioration in function.
CONCLUSIONS : Frailty can be measured in older ICU survivors near hospital discharge and is associated with 6-month mortality in unadjusted analysis.
CONCLUSIONS : Frailty is a common finding in patients with EOC and is independently associated with worse surgical outcomes and poorer OS.
CONCLUSIONS : Frailty is common in critically ill adults aged @number@ years and older and is independently associated with increased mortality and greater disability.
CONCLUSIONS : Frailty is independently associated with risk of HF in older adults.
CONCLUSIONS : Frailty may independently predict reduced clearance of gentamicin in older patients.
CONCLUSIONS : Frailty results in a 3- to 8-fold increase in risk of postoperative delirium , independent of the EuroSCORE II.
CONCLUSIONS : Frailty was not simply a geriatric syndrome , but the combination of multiple geriatric syndromes.
CONCLUSIONS : French Olympic rowers benefit of lower overall mortality compared with the French general population.
CONCLUSIONS : From a risk-benefit perspective , there is a role of statins for the primary prevention of major adverse cardiovascular events in elderly patients.
CONCLUSIONS : From @number@ to @number@ the 1-year risk for ischemic stroke after AMI declined , whereas the risk of hemorrhagic stroke remained unchanged.
CONCLUSIONS : FR were most associated with neural disruptions occurring at the encoding phase when subjects must attend to and encode items.
CONCLUSIONS : FS presented higher bond strength and lower nanoleakage and was not affected by simulated aging.
CONCLUSIONS : Functional status most strongly predicted ER use , highlighting the promise of home-based interventions to improve activities of daily living.
CONCLUSIONS : Fungemia , mostly due to Candida spp. , was rare in cancer patients from EORTC centers but was associated with substantial mortality.
Conclusions : Further investigation of the prognostic value of carotenoid concentrations , and their changes , on cognition in similar population-based samples longitudinally is warranted.
CONCLUSIONS : Further investigations are needed to determine precisely the pathophysiological roles of plasma Aβ1-40 and cystatin C and before envisioning any future clinical applications.
CONCLUSIONS : Future evaluation may include additional assessments of nutrients for the treatment of progression of cataract and AMD.
CONCLUSIONS : Future investigations should consider prospective longitudinal design using neuroimaging and CSF measures of Aβ.
CONCLUSIONS : Future research development and implications are discussed.
CONCLUSIONS : Future research is needed to determine how differences in associations by neighborhood characteristics may contribute to racial disparities in obesity.
CONCLUSIONS : Future research is needed to further evaluate how the views of people with traumatic SCI change over time.
CONCLUSIONS : FVA testing seems to be a useful method of assessing the age-related decline in dynamic visual and tear functions.
CONCLUSIONS : Gabapentin and pregabalin appear useful for treating pain and other secondary conditions after SCI.
CONCLUSIONS : GAD but not depression was associated with increased systolic BPV over an 8year period controlling for HBPM.
CONCLUSIONS : Gait changes in frail patients include more than solely a reduction in walking speed.
CONCLUSIONS : Gait speed is a clinical marker and an important measure of functional capacity among the elderly.
CONCLUSIONS : GEN3VA can be used to identify , aggregate , and analyze themed collections of gene expression signatures from diverse but related studies.
CONCLUSIONS : Gender and advancing age may influence corneal biomechanical properties.
CONCLUSIONS : Gender and premenopausal status do not affect age-related decreases in T / S and associations between T / S and PWV.
CONCLUSIONS : Gender and social relations are important determinants of experiencing violence in older adults.
CONCLUSIONS : Gender strongly influences which sarcopenia-related parameters predict disability.
CONCLUSIONS : Gender , visual impairment and orthostatic hypotension were identified as the major risk factors of fall injuries in the elderly.
CONCLUSIONS : Gene expression in non-tumor lung tissue is modulated by both sex and age.
CONCLUSIONS : Genetic analyses in human and mouse models revealed the importance of SLC25A24 / Slc25a24 in the regulation of body fat mass and adipogenesis.
CONCLUSIONS : Genetic background is not only crucial in disease pathogenesis , but it also modulates disease course.
CONCLUSIONS : genetic factor and common family environment have a limited contribution to cognitive function in the Chinese adults.
CONCLUSIONS : Genetic variation in the transcription factor SOX5 is associated with COPD susceptibility.
CONCLUSIONS : Genitourinary pathologists ordered significantly fewer IHC stain tests than non-GU pathologists in ECPBs.
CONCLUSIONS : Geriatric syndromes and hypoglycemia are associated with lower HRQL to a comparable degree as diabetes complications.
CONCLUSIONS : German cancer survival estimates are mostly higher than the 2000-2002 pan-European estimates.
CONCLUSIONS : GH serum excess seems to carry an increased risk of developing intracranial aneurysms.
CONCLUSIONS : Given that polyamines can interact with many molecules , it is not surprising that they affect aging via several mechanisms.
CONCLUSIONS : Given the reciprocal relationships between sleep and daily experiences , efforts to improve well-being in daily life should reflect the importance of sleep.
CONCLUSIONS : Glabella and forehead lines can be effectively and safely reduced with neurotoxin alone as well as neurotoxin in combination with fillers.
CONCLUSIONS : Global clinical scales such as CDR-SB and ROSA should be considered for use with treatments aiming at slowing disease progression.
Conclusions : Global cognitive performance was most strongly associated with long-term cognitive decline following delirium.
CONCLUSIONS : Globally , age-standardized acute myocardial infarction incidence and angina prevalence have decreased , and ischemic heart failure prevalence has increased since @number@
CONCLUSIONS : Grantees have successfully delivered CDSMP to racially and ethnically diverse participants in a range of settings.
CONCLUSIONS : Gravidity was not associated with telomere length in early middle age ; the protective association of 2-3 births may act through other mechanisms.
CONCLUSIONS : Gray matter hypertrophy and thickening were associated with hypoxemia , respiratory disturbances , and sleep fragmentation.
CONCLUSIONS : Greater baseline CIMT was independently associated with the risk of cognitive impairment , such as MCI and dementia in elderly subjects.
CONCLUSIONS : Greater fish intake may help to reduce bone loss in this sample of elderly Chinese men.
CONCLUSIONS : Greater fruit intake was independently associated with better bone mineral status among Chinese elderly men and women.
CONCLUSIONS : Greater height and lower functional disability were found for both older South African men and women to be significantly associated with grip strength.
CONCLUSIONS : Greater impairment across five organ systems was associated with slower gait speed and greater declines in gait speed over @number@ years.
CONCLUSIONS : Greater loneliness is associated with lower cognitive function.
CONCLUSIONS : Greater muscle strength and area were independently associated with 15-30% decreased risk of mobility disability in women and gait speed decline in men.
CONCLUSIONS : Greater PUFA concentrations may be associated with lower osteoporotic fracture risk in older adults , particularly in men.
CONCLUSIONS : Greater wellbeing is associated with a reduced risk of COPD , particularly in men.
CONCLUSIONS : Green vegetables , total FVI , and various aspects of PA showed protective effects regarding CRLDS.
CONCLUSIONS : Group expectations and preferences differ substantially.
CONCLUSIONS : Growing attention is being given to population risk reduction to combat the dramatic increase in the burden of disease due to dementia.
CONCLUSIONS : GT placement can be well tolerated and associated with easier mealtimes in patients with A-T when feeding tubes are placed at young ages.
CONCLUSIONS : HA IDF plus significantly reduced the injection-related pain during NLFs correction compared with HA IDF without altering clinical outcomes or safety.
CONCLUSIONS : Handgrip strength predicted accelerated 1-year decline in cognitive function , assessed by CDT , in a sample of older adults.
CONCLUSIONS : Hand-held dynamometry is a reliable instrument to measure the foot and ankle strength of young and older adults.
CONCLUSIONS : Hardcore smoking was more prevalent among men , unmarried men and those aging 40-49 years.
CONCLUSIONS : Having a high level of mid-life SES and living with a partner are associated with better cognition for both cohort groups.
CONCLUSIONS : Having children is associated with increased longevity , particularly in an absolute sense in old age.
CONCLUSIONS : Having conflicts with others and accumulation of adverse life events over time partly explained the association between ADHD and depression.
CONCLUSIONS : Having friends was a significant predictor of continuity in home care.
CONCLUSIONS : Hazardous alcohol consumption appears to be a key factor of the dropout rate in a Web-based alcohol intervention study.
CONCLUSIONS : HbA1C-derived eAG values may not accurately reflect CGM-measured mean glucose or MAGE in older adults with diabetes.
CONCLUSIONS : HCC derived from non-viral liver disorders was dominant in the elderly patients.
CONCLUSIONS : HDL-associated paraoxonase is responsible for the anti-inflammatory and anti-oxidative properties of HDL and detoxification against homocysteine-thiolactone.
CONCLUSIONS : HDL-C was the main lipoprotein affecting cognitive function , with results somewhat more pronounced among women.
CONCLUSIONS : Health care providers differ in their potential to shorten sickness absence duration.
CONCLUSIONS : Health-care providers should develop gender-based strategies to improve mental health among older survivors in a long-term post-disaster recovery programme.
CONCLUSIONS : Health expenditure , YLDs , costs and prevalence of neurological conditions were generally not correlated across the eight countries.
CONCLUSIONS : Health literacy decline appeared to increase with age , and was associated with even subtle cognitive decline in older non-impaired adults.
CONCLUSIONS : Health literacy influences knowledge about heart failure but not self-care adherence.
CONCLUSIONS : Health literacy should be considered when educating older adults about vitamin D supplements and sunlight exposure.
CONCLUSIONS : Health promotion and prevention interventions are not intentionally integrated into community occupational therapy practice with seniors having disabilities.
CONCLUSIONS : Health promotion efforts for physical activity have mostly focused on moderate-to-vigorous activity.
CONCLUSIONS : Healthy aging is associated with neuromuscular transmission instability ( increased NF jiggle ) and MU remodeling , which can be measured using DQEMG.
CONCLUSIONS : Hearing disorders are relevant in elderly individuals and they affect their perceived quality of life in a noticeable manner.
CONCLUSIONS : Hearing impairment is a common condition in middle-aged adults.
CONCLUSIONS : Hearing loss can negatively affect a patient's ability to actively participate in diabetes education.
CONCLUSIONS : Hearing loss correlates with an increased risk of Parkinson's disease in the elderly.
CONCLUSIONS : Hearing loss is independently associated with incident all-cause dementia.
CONCLUSIONS : Heart failure imposes a huge economic burden , estimated at $ 108 billion per annum.
CONCLUSIONS : Heart failure patients in primary care are elderly , with significant co-morbidities and treated with a high number of drugs.
CONCLUSIONS : Heart failure with preserved ejection fraction was the most common HF type and vascular dementia was the most common dementia disorder.
CONCLUSIONS : Heart rate is prone to be affected by emotional responses among pediatric patients in certain specific age groups.
Conclusions : Here , sutural information from humans of @number@ to @number@ years of age was obtained.
CONCLUSIONS : Heretofore , the network analysis from time series gene expression data has been focused on what topological structure was changed over time point.
CONCLUSIONS : Here , we firstly report that ARE inhibits PDHK activity and growth of tumor in both in vitro and in vivo experiments.
CONCLUSIONS : Here we identify and characterise an epigenetic predictor of age in mice , the mouse epigenetic clock.
CONCLUSIONS : Herpes zoster is an established risk factor for increasing the risk of stroke , especially shortly after infection.
CONCLUSIONS : HGS might be considered instead of BMI in MNA-SF test to assess nutritional status of geriatric patients.
CONCLUSIONS : High BP in childhood and increased BP from childhood to adulthood impacts on retinal microvascular architecture in mid-adulthood.
CONCLUSIONS : High concentrations of UTP were associated with lower prevalence of frailty and prefrailty in an older community-dwelling population.
CONCLUSIONS : High dietary vitamin K intake was associated with superior bone properties.
CONCLUSIONS : High-dose NOACs provide overall efficacy and safety similar in AF patients with or without VHD.
CONCLUSIONS : Higher 24-hour DBP and greater nighttime systolic dipping were significantly associated with improved cognitive function.
CONCLUSIONS : Higher anxiety may exacerbate the effects of cerebral hypoperfusion on cognitive impairment.
CONCLUSIONS : Higher aortic stiffness was associated with higher LV mass , independently of pressure.
CONCLUSIONS : Higher cerebral glutathione concentrations were associated with greater dairy consumption in older adults.
CONCLUSIONS : Higher cognitive functioning was associated with the way in which older people perceive their current sexuality.
CONCLUSIONS : Higher dietary sodium intake is associated with shorter telomere length in overweight and obese adolescents.
CONCLUSIONS : Higher diet quality was prospectively associated with better quality of life and functional ability.
CONCLUSIONS : Higher fasting and OGTT values of both glucose and insulin are associated with lower muscle mass.
CONCLUSIONS : Higher HR reactivity to acute psychological stress is related to better executive function in older adults.
CONCLUSIONS : Higher incidence of random aneuploidy and senescence were observed in amniocytes from fetuses with trisomy.
CONCLUSIONS : higher level of physical activity and lower energy intake may be protective against the development in ADL and IADL disability in older persons.
CONCLUSIONS : Higher levels of depressive symptoms are associated with worse performance in specific quantitative gait variables in community-residing older adults.
CONCLUSIONS : Higher levels of EI were associated with lower levels of strength and greater frailty.
CONCLUSIONS : Higher levels of physical activity may reduce the effect of WMH burden on motor function in healthy older adults.
CONCLUSIONS : Higher levels of physical fitness were associated with a reduced risk of suffering SO and better perceived health among elderly.
CONCLUSIONS : Higher life satisfaction is associated with fewer doctor visits , which may have important implications for reducing health care costs.
CONCLUSIONS : Higher mFI , independent of other risk factors , is associated with higher mortality and morbidity in patients undergoing elective EVAR and OAR.
CONCLUSIONS : Higher midlife CRF may play a role in preserving middle and medial temporal volumes in late adulthood.
CONCLUSIONS : Higher Openness to Experience was associated with a reduction in risk for cognitive decline in community-dwelling older adults.
CONCLUSIONS : Higher plasma Aβ42 at baseline predicted the development of first episode of LOD and conversion to probable or possible AD.
CONCLUSIONS : Higher plasma klotho concentrations were associated with lower risk of meaningful decline and smaller average decline in MMSE.
CONCLUSIONS : Higher prediagnostic levels of serum sRAGE were associated with lower risk of colorectal cancer in male smokers.
CONCLUSIONS : Higher pulse pressure at any age and higher pulse pressure with advancing age is associated predominantly with a larger forward pressure wave.
CONCLUSIONS : Higher PWV is common in younger and middle-aged ischemic stroke patients and associated with a clustering of classical cardiovascular risk factors.
CONCLUSIONS : Higher QoL attenuates processes of functional decline in late adulthood.
CONCLUSIONS : Higher serum adiponectin concentration was associated with increased all-cause and cardiovascular mortality in community-dwelling elderly Asian population.
CONCLUSIONS : Higher serum CML levels in late life are associated with incident disability and prevalent frailty.
CONCLUSIONS : Higher serum DHT level and DHT / TT ratio were associated with larger prostate volume and higher prevalence of BPH in Taiwanese men.
CONCLUSIONS : Higher serum leptin levels were inversely associated with AMD.
CONCLUSIONS : Higher stride time variability was associated with larger temporal horns in older community-dwellers.
CONCLUSIONS : Higher TLR2 methylation may confer susceptibility to adverse cardiac autonomic effects of PM2.5 exposure in older individuals.
CONCLUSIONS : Higher total WBC , granulocyte and neutrophil counts were associated with higher risk of incident CHD in a population of elderly Japanese-American men.
CONCLUSIONS : Higher vitamin C intake and serum ascorbate might be inversely associated with risk of cataract.
CONCLUSIONS : High fatness was associated with lower muscle quality , and it predicts accelerated loss of lean mass.
CONCLUSIONS : High folate or folic acid supplements may be detrimental to cognition in older people with low vitamin B12 levels.
CONCLUSIONS : High-intensity telemedicine significantly reduced ED use among SLC residents without increasing other utilization or mortality.
CONCLUSIONS : High leptin levels were independently associated with a reduced risk of cognitive decline in elderly Italians.
CONCLUSIONS : Highly fluctuating impairment of diastolic function relative to arterial elasticity may predispose elderly women to pulmonary edema.
CONCLUSIONS : High mFI is associated with postoperative morbidity and mortality after PD and can aid in preoperative risk stratification.
Conclusions : High sc- @time@ is associated with low TBS and an increased prevalence of radiologic VFx independently of other risk factors.
CONCLUSIONS : High-speed yoga results in a significantly greater caloric expenditure than standard-speed yoga.
CONCLUSIONS : HI in older adults is associated with increased mortality , independent of demographics and cardiovascular risk factors.
CONCLUSIONS : HIIT and CON are both well tolerated and induce similar improvements in physical components of HRQoL and in markers of anxiety.
CONCLUSIONS : Hip and knee OA is one of the leading causes of global disability.
CONCLUSIONS : Hip fractures are more common among females irrespective of age group.
CONCLUSIONS : Hippocampal atrophy rates increase with age with the largest increases occurring from midlife onwards.
CONCLUSIONS : Hippocampus is a promising traditional medicine and holds great potential for being exploited as healthy products and drugs.
CONCLUSIONS : History of TBI is most prevalent in men , older African-Americans in poverty , and younger Whites in poverty.
CONCLUSIONS : HIV-infected adults had a higher risk of these age-associated events , but they occurred at similar ages than those without HIV.
CONCLUSIONS : HIV infection is associated with an increased ischemic stroke risk among HIV-infected compared with demographically and behaviorally similar uninfected male veterans.
CONCLUSIONS : HIV infection is associated with elevated IL-6 , sCD14 , and D-dimer , which are in turn associated with mortality.
CONCLUSIONS : HIV infection is associated with longitudinal changes in serum levels of several biomarkers of end-organ function / disease and mortality.
CONCLUSIONS : HIV is associated with an increased risk of CVD in women.
CONCLUSIONS : HIV-obesity comorbidity is associated with elevated IL-6 , decreases in sCD14 , and no significant difference in D-dimer.
CONCLUSIONS : HIV-positive patients who use ART are more likely to have received health care services for diabetes and hypertension.
CONCLUSIONS : HO-1 promotes mitochondrial damage and CA biogenesis in astrocyte cultures and in the intact aging brain.
CONCLUSIONS : Home and community-based physical activity interventions may be a potential tool to combat functional deterioration among aging cancer survivors.
CONCLUSIONS : Home biofeedback was acceptable and well tolerated by all users.
CONCLUSIONS : Homeostatic sleep regulation and sleep architecture in young depressed women are not equal to premature aging.
CONCLUSIONS : Home visits by commissioned welfare volunteers are significantly associated with a lower risk of psychological distress among older people.
CONCLUSION : Shopping behaviour favourably predicts survival.
CONCLUSION : Short- and long-term dermal fillers are increasingly becoming popular treatment options for signs of facial aging.
CONCLUSION : Shorter lactation duration is associated with subclinical atherosclerosis independent of prepregnancy cardiometabolic risk factors and traditional risk factors.
CONCLUSION : Short telomere length and depressive symptoms are associated with bladder cancer mortality individually and jointly.
CONCLUSIONS : Hospitalization is a frequent event for AD patients even at mild to moderate stage of the disease.
CONCLUSIONS : How individuals reach late-midlife BMI is important.
CONCLUSIONS : HP is not extremely rare.
CONCLUSIONS : HPV testing represents a more sensitive methodology for primary cervical cancer screening compared to cytology.
CONCLUSIONS : Human myofibers survive permanent denervation longer than generally accepted and they respond to h-bFES beyond the stage of simple atrophy.
CONCLUSIONS : Human prostate cells exhibited differential reactions to hypoxia and oxidative stress with widespread DNA damage.
CONCLUSIONS : Hyaluronic acid filler intradermal injection with special injector is a safe and effective method for correction of nasojugal groove.
CONCLUSIONS : Hydrocephalus and delayed cerebral ischemia , while infrequent , do occur in SAH of unknown origin.
CONCLUSIONS : Hyperkyphosis is associated with impaired lower extremity physical function in older men.
CONCLUSIONS : Hypertension , arthritis , and stroke are important in terms of total QALY loss , which will continuous to increase because of aging.
CONCLUSIONS : Hypertension increases the risk of concurrent impairments in mobility , cognition , and mood , which increases disability and mortality.
CONCLUSIONS : Hypertension is frequent in France , particularly in the age group 55-74 years.
CONCLUSIONS : Hypogonadal symptoms in men aged < 40 years can be associated with a TT level of < 400 ng / dL.
CONCLUSIONS : Hypoxia stimulates the generation of ROS , and the ROS may play a key role in BPH.
CONCLUSIONS : IADL limitation stages could represent a powerful and practical tool for screening patients in the U.S. elderly population according to fall risk.
CONCLUSIONS : IART is the most common presenting atrial arrhythmia in patients with congenital heart disease , with a predominantly paroxysmal pattern.
CONCLUSIONS : ICO revealed potential value to predict PDDU changes in a MetS context.
CONCLUSIONS : ICP-SF-MS is a reliable method of blood analysis for Cd , Mn and Pb even for the evaluation on an individual basis.
CONCLUSIONS : Ideal CVH status for BMI , total cholesterol , and blood pressure was prevalent in young children , whereas ideal diet was rare.
CONCLUSIONS : Identification of disease-causing mutations in BHD syndrome requires the analysis of intronic sequences.
CONCLUSIONS : Identification of the CTS correlates in younger group would be of greater value in timely detection and treatment for these diseases.
CONCLUSIONS : Identifying gender heterogeneity in widowhood effects can guide further efforts to devise gender-tailored programs to enhance healthy aging.
CONCLUSIONS : Identifying individuals with MCI who will progress to dementia or more severe cognitive impairment is a challenge.
CONCLUSIONS : Identity-related struggles are a significant feature of academic physicians ' considerations about late-career transitions.
CONCLUSIONS : iDiet participants had clinically impactful mean WL.
CONCLUSIONS : IDTS is a workforce tracking model that can be used to understand trends at the community , regional and state levels.
CONCLUSION : SIF concentrations in middle-aged healthy subjects were increased with an age-related degeneration in renal function.
CONCLUSIONS : IFi is a valid measure of frailty after the comprehensive geriatric assessment in an Italian cohort of non-institutionalized patients.
CONCLUSIONS : If present , dietary effects on cognition are likely group-specific.
CONCLUSIONS : if the materials were applied according to the manufacturer's instructions , no retention loss was observed in the laboratory model.
CONCLUSIONS : If the trend of health related indicators continues , it is estimated that COI of stomach cancer would decrease.
CONCLUSIONS : If VEP results are normal , visual acuity loss is usually functional.
CONCLUSIONS : IFX is effective and safe for induction and maintenance therapy in Chinese patients with moderate-to-severe active intestinal BD.
CONCLUSION / SIGNIFICANCE : Overall , these findings indicate that memory self-efficacy beliefs modulate brain activity during intentional encoding.
CONCLUSION : Significant adverse effects of poor hearing on loneliness were found for specific subgroups of older persons.
CONCLUSION : Significant changes in the intracuff pressure occur with changes in head and neck position.
CONCLUSION : Significant changes in the teaching of dental management of the elderly are critical within much of the education community.
CONCLUSION : Significantly raised MCP-1 levels in obese and SO subjects support the theory of chronic inflammation due to excess adiposity.
CONCLUSION : Significant microstructural tract-specific maturation processes continue throughout late childhood into adulthood.
CONCLUSION : Signs of peripheral neuropathy remain despite virologic / immunologic control but frequently occurs without symptoms.
Conclusions : IL28B-CC genotype and 12-month postpartum undetectable viremia were the best predictors for viral decline and subsequent clearance.
CONCLUSION : Silent cerebrovascular lesions are associated with future risk of decline in higher level functional capacity.
CONCLUSION : Silent myocardial ischemia may contribute to cerebrovascular disease in non-demented elderly men.
CONCLUSIONS : Imaging findings of spine degeneration are present in high proportions of asymptomatic individuals , increasing with age.
CONCLUSIONS : Imbalance of glycosyltransferases , glycosidases and sugar nucleotide donor levels is able to cause the structural changes evidenced by our findings.
CONCLUSION : Similarities and differences in depression attributes between Mexican-origin and white non-Hispanic older men suggest the confluence of various sociocultural factors.
CONCLUSION : Similar Meaning in Life-profiles were detected in residential as well as community-dwelling older adults.
CONCLUSION : Similar to the original HIS-Q , the HIS-Q-SF has evidence supporting reliability , validity , and responsiveness.
CONCLUSIONS : Immigrants are underrepresented in Berlin´s HPC and immigrants on average make use of care at a younger age than non-immigrants.
CONCLUSIONS : Immune activation associated with HIV infection and impaired pTfh function heighten deficiencies in antibody responses to influenza vaccine in older individuals.
CONCLUSIONS : Immune senescence is significantly worse in elderly cancer patients than in age-matched controls.
CONCLUSIONS : Impaired capacity to perform activities of daily living was the main reason for care allocation.
CONCLUSIONS : Impairment in odor identification was superior to deficits in verbal episodic memory in predicting cognitive decline in cognitively intact participants.
CONCLUSIONS : Impairments in odor identification are common in patients with TEA and exceed changes that occur in normal aging.
CONCLUSIONS : Implementation of cocooning for protecting newborns from pertussis is challenging and usually remains incomplete.
CONCLUSIONS : Implementing an asset-based approach to health promotion uncovers the skills , knowledge , connections and potential of the individual and the community.
Conclusions / implications for management and research.
CONCLUSIONS / IMPLICATIONS FOR PRACTICE : Negative perceptions about aging are associated with reports of poor sleep quality.
CONCLUSIONS / IMPLICATIONS FOR PRACTICE : The RISE is a valid and reliable tool for measuring the social engagement of nursing home residents in Korea.
CONCLUSIONS / IMPLICATIONS FOR PRACTICE : This study confirmed that QoL and ADL correlate significantly with MCI in older people.
CONCLUSIONS : Imprinted genes were identified in skeletal muscle gene networks and exercise-associated DNA methylation change.
CONCLUSIONS : Improvement in access to care resulted in greater utilization of home care.
CONCLUSIONS : Improvement in nitrogen accretion was blunted at lower protein intakes in critically ill , older patients compared with younger patients.
CONCLUSIONS : Improvements in high-sensitivity CRP were not associated with postoperative cognitive benefits.
CONCLUSIONS : In addition to age , increased adiposity and insulin levels were strong predictors for impaired arterial elasticity.
CONCLUSIONS : In addition to cerebellar ataxia , extrapyramidal symptoms , especially bradykinesia , were frequent and disabling.
CONCLUSIONS : In adults with steady-state bronchiectasis , sleep disturbances are more common than in healthy subjects and are related to poorer QoL.
CONCLUSIONS : - In advanced old age , the substrates of cognitive impairment are often multifactorial.
CONCLUSIONS : In AIS patients , MMP-2 levels are associated with the pre-existing burden of WMH.
CONCLUSIONS : In a Korean population , the mean IOP , total cholesterol , TG , and BMI values of men were higher than women.
CONCLUSIONS : In all participants together , 3D-accelerometry based gait speed and regularity showed high reliability when based on two walks of @number@ m.
CONCLUSIONS : In an aging population , we found ethnic differences in GLI-defined respiratory impairment.
CONCLUSIONS : In an asymptomatic , senescent community-dwelling population , we observed a distinct , sex-specific pattern of cardiac remodeling.
CONCLUSIONS : In a population-based case-control study , the risk of CRC was strongly reduced up to @number@ years after colonoscopy for any indication.
CONCLUSIONS : In a population of older hypertensive patients , higher plasma homocysteine was associated with cognitive decline.
CONCLUSIONS : In a rural setting , mobility is associated with multiple EF processes.
CONCLUSIONS : In asymptomatic men there is a weak correlation between IPSS , prostate size and uroflowmetric data.
CONCLUSIONS : In both genders , urinary incontinence and polypharmacy seem to be the most important risk factors for fecal incontinence.
CONCLUSIONS : In cancerous colonic mucosa the reduced SST production may contribute to the uncontrolled cell proliferation.
CONCLUSIONS : Incentive spirometry performance is influenced by age , and the differences between elderly and healthy adults response should be considered in clinical practice.
CONCLUSIONS : Incidence of cognitive impairment is high in hospitalized patients with chronic heart failure.
CONCLUSIONS : Incidence of hypertension in particular age groups of HIV infected people is higher than in the general Polish population.
CONCLUSIONS : Incidence of microbleeds in the general population over a 3-year interval was substantial and microbleeds rarely disappeared.
Conclusions include recommendations for future research and implications for practice in the field.
CONCLUSIONS : Income inequality might contribute to short life expectancy and adult mortality in part because of societal differences in trust.
CONCLUSIONS : in community-dwelling older adults , foot problems , arthritis , cognitive impairment , heart problems and vision were the major determinants of disability.
CONCLUSIONS : In compensated HCV-related cirrhosis , SVR markedly reduces the risk of HCC and improves survival.
CONCLUSIONS : In conclusion , advancing age negatively impacts stem cell function and such age related alterations may be detrimental for successful stem cell therapies.
CONCLUSIONS : In conclusion , age , weight , and BMI are important factors in determining breast anthropometry in our study.
CONCLUSIONS In conclusion , both the donor's and the recipient's rs2735940 hTERT gene polymorphism was associated with early graft function after transplantation.
CONCLUSIONS : In conclusion , severe knee pain was independently associated with fruit and vegetable consumption.
CONCLUSIONS : In contrast to our hypothesis , plasma leptin was higher in Danish children despite a more healthy metabolic profile compared to Inuit children.
CONCLUSIONS : In contrast to the 48-hour turnaround for classical microbiological culture , these results were available within 1-2 h.
CONCLUSIONS : In contrast to the increased prevalence of GERD , gastric acid secretion has not increased over the past two decades in Japanese.
CONCLUSIONS : Increased CD66b + TIN was significantly associated with presence of metastasis , S stage , and nonseminomatous germ cell tumor diagnosis.
CONCLUSIONS : Increased CSF NFL indicates ongoing axonal injury in many neuroasymptomatic patients.
CONCLUSIONS : Increased IIV over time is associated with normal ageing.
CONCLUSIONS : Increased knowledge of management of patients affected by dementia could help professional care-givers to reduce their work-related stress.
CONCLUSIONS : increased levels of LTPA across mid-life were associated with stronger grip at age 60-64 , in both men and women.
CONCLUSIONS : Increased levels of short-term traffic-related pollutants may increase the risk of ventricular arrhythmia in elderly subjects.
CONCLUSIONS : Increased neuritic plaque accumulation may explain the association between heavy use of nonselective NSAIDs and increased risk of dementia among ACT participants.
CONCLUSIONS : Increased public health attention to behavioral adaptations to functional change can promote independence for older adults and may enhance quality of life.
CONCLUSIONS : Increased RPE survival can be achieved on aged submacular human Bruch's membrane by resurfacing the latter with a cell-deposited ECM.
CONCLUSIONS : Increased sleep-stage transitions notably from ≥2.5 min of W / N1 into REM are specifically diagnostic for narcolepsy independent of a nocturnal SOREMP.
CONCLUSIONS : Increases in cervicothoracic curvature occurring along with thoracic deformation underlie age-related changes in the spine.
CONCLUSIONS : Increases in neighborhood-level foreclosure represent an important risk factor for depression in older adults.
CONCLUSIONS : Increasing age has a significant effect on USCOM scan quality and data reliability.
CONCLUSIONS : Increasing ambient humidity reduces heat loss capacity in young and older women.
CONCLUSIONS : Increasing dementia severity and higher comorbidities are associated with higher Medicare expenditures.
CONCLUSIONS : Increasing fruit consumption may be one important factor for reducing both the prevalence and incidence of depressive symptoms in mid-age women.
CONCLUSIONS : Increasing hepatic arteriolar wall thickness and decreased arteriolar cross-sectional diameter occur with increasing age in the normal human liver.
CONCLUSIONS : Increasing levels of stress are independently associated with accelerated declines in cognitive function in black and white adults @number@ years and older.
Conclusions : Increasing objective daytime sleepiness in early adolescence cannot simply be attributed to reduced sleep due to restricted sleep schedules.
CONCLUSIONS : Increasing or maintaining LTPA is associated with greater longevity in older adults , even those with obesity or functional limitations.
CONCLUSIONS : Increasing the total amount of leisure activity levels may help lower depressive symptoms in inactive older adults with cognitive complaints.
CONCLUSIONS : Increasing triglycerides but not other lipid fractions were associated with MRI markers of cerebral small vessel disease in older community persons.
CONCLUSIONS : Increasing whole-grain intake is associated with lower VAT in adults , whereas higher intakes of refined grains are associated with higher VAT.
CONCLUSIONS : In Denmark , birth season and birth year cohort effects influenced timing and risk of antibiotic prescribing during infancy.
Conclusions : Independent from dietary macronutrient proportions , there is a strong individual contribution to fuel preference that remains consistent across diets.
CONCLUSIONS : Independent of age and other shared risk factors , arterial stiffness is inversely related to cortical bone area in women.
CONCLUSIONS : Independent of established cardiovascular disease , some vascular risk factors are associated with functional impairment.
CONCLUSIONS : Independent of multiple risk factors and cerebral vascular damage , global brain volume predicts mortality in a large nondemented stroke-free community-dwelling older cohort.
CONCLUSIONS : In depressed individuals , clinically relevant apathy was more frequently present in older compared to younger persons.
CONCLUSIONS : Individual cognitive test scores related to distinct SBP management with more intensive management appearing more robust against confounders.
CONCLUSIONS : Individually tailored dietary counseling may improve nutritional status among older home care clients.
CONCLUSIONS : Individual personality traits within the neuroticism dimension are associated with treatment resistance and cognitive impairment in LLD.
CONCLUSIONS : Individuals with ET and normal cognition accurately assessed their language and executive abilities , demonstrating mild overconfidence in memory function.
CONCLUSIONS : Individuals with RA may be at a higher risk for sleep disturbances compared with individuals without RA.
CONCLUSIONS : Indoxyl sulfate downregulates Klotho expression in kidneys through production of reactive oxygen species and activation of NF-κB in proximal tubular cells.
CONCLUSIONS : In elderly patients with MDD , BLT improved mood , enhanced sleep efficiency , and increased the upslope melatonin level gradient.
CONCLUSIONS & INFERENCES : The number and volume of ICC networks in the normal human stomach and colon decline with age.
CONCLUSIONS : Inflammation and adiposity might relate to cognitive decline via influences on brain morphology.
CONCLUSIONS : inflammation is associated with the loss of TASM in free-living non-sarcopenic older men and women.
CONCLUSIONS : Inflammation is initiated from the abnormal alveolar epithelial cells in HPS , and S-nitrosylated SP-D plays a significant role in amplifying pulmonary inflammation.
CONCLUSIONS : Inflammation was higher in older participants living in the Latin American cities compared with their Canadian counterparts.
CONCLUSIONS : Informal care is the main source of help for community-dwelling older adults with functional limitations.
CONCLUSIONS : Information based only on average consumption underestimates the risk of drinking problems among older adults.
CONCLUSIONS : Information is lacking regarding HRQOL in Japanese populations.
CONCLUSIONS : In frail older people , hip fracture co-management , with the geriatrician as primary attendant , leads to satisfying outcomes.
CONCLUSIONS : In general , elder participants recruited more brain regions in comparison to younger participants to reach similar accuracy levels.
CONCLUSIONS : In general , intervention mapping was a useful method to develop a workplace health promotion and wellness program aimed at reducing presenteeism.
CONCLUSIONS : In geriatric oncology , an accurate predictive test to guide anticancer treatment in order to prevent serious toxicity is needed.
CONCLUSION : Single-level AxiaLIF is a safe and effective means to achieve lumbosacral fusion in patients with symptomatic degenerative disc disease.
CONCLUSIONS : In healthy subjects , reference values of LV 3D strain parameters were significantly influenced by demographic , cardiac , and technical factors.
CONCLUSIONS : Inhibition of the proinflammatory NF-κB pathway resulted in increased expression of ECM proteins in vitro and significant clinical improvement in photodamaged skin.
CONCLUSIONS : Initiation of ART significantly reduced the rate of hepatic decompensation by 28%-41% on average.
CONCLUSIONS : In Japanese adults , sex-specific changes in skeletal muscle mass are more prominent in the arm than in the leg.
CONCLUSIONS : In Japanese older persons , the Japanese dietary pattern is associated with a decreased risk of incident functional disability.
CONCLUSIONS : Injection of diluted CaHA is very effective for skin tightening of the neck and décolletage. < em > J Drugs Dermatol.
CONCLUSIONS : Injured workers past typical retirement age appeared to be a disadvantaged group with significant challenges from a vocational rehabilitation perspective.
CONCLUSIONS : In keratoconus , the steepest part of the cone can be located temporally , especially in younger patients , which is unusual.
CONCLUSIONS : In Korean older adults , type @number@ diabetes is associated with low muscle mass.
CONCLUSIONS : In line with previous results , older adults ' postural stability was improved after balance training.
CONCLUSIONS : In men , low testosterone is an independent risk factor for high FG , comparable to aging and obesity.
CONCLUSIONS : In mouse models of obesity , we found that PHLPP2 degradation induced lipogenesis without affecting gluconeogenesis.
CONCLUSIONS : Inner retinal layer thickness , as measured by FD-OCT , varies significantly with age and axial length.
CONCLUSIONS : In normal healthy subjects , LA indexed volumes remain nearly stable until the eighth decade when they increase significantly.
CONCLUSIONS : In obese adults , intentional weight loss may be associated with approximately a @percent@ reduction in all-cause mortality.
CONCLUSIONS : In obesity , both OSA and aging impair endothelial function and increase arterial stiffness.
CONCLUSIONS : In older adults , elevated levels of sTNF-R1 are associated with increased risk for incident HF.
CONCLUSIONS : In older adults , variable agreement between in vivo imaging and CERAD NP score was observed.
CONCLUSIONS : In older community-dwelling adults , plasma klotho is an independent predictor of all-cause mortality.
CONCLUSIONS : In older individuals , higher AT1RaAb levels were associated with inflammation , hypertension , and adverse outcomes.
CONCLUSIONS : In older men , both lower and higher IGF1 and IGFBP3 levels may be metabolically unfavourable.
CONCLUSIONS : In older men , gonadal status is independently associated with some determinants ( haemoglobin and muscle strength ) of physical performance.
CONCLUSIONS : In older men , testosterone increases GH pulse frequency while the aromatization to estradiol is involved in the rise of IGF-1 levels.
CONCLUSIONS : In older persons , diabetes is associated with reduced muscle strength and worse muscle quality.
CONCLUSIONS : In older persons , MetS is associated with reduced probability of prevalent and incident ADLs disability.
CONCLUSIONS : In older women , β-carotene levels are independently and inversely associated with E2.
CONCLUSIONS : In our clinical setting , the average age of patients with newly diagnosed exudative AMD increased significantly between @number@ and @number@
CONCLUSIONS : In our general population , we observed that oxidative stress is related to aging , but antioxidant capacity is not.
CONCLUSIONS : In our sample , the p.A152T MAPT variant does not appear to show a discernible influence on the clinical phenotype of GRN carriers.
CONCLUSIONS : In our sample , which was representative of the Dutch population , multimorbidity was associated with subjective memory complaints.
CONCLUSIONS : In patients undergoing plastic surgery , wound dehiscence is a rare complication ( @number@ percent ) .
CONCLUSIONS : In patients with a symptomatic nodular goiter , serum T4 and age are the major determinants of the thyroid RAIU.
CONCLUSIONS : In patients with cancer of the larynx without macroscopically visible neoplastic lesions in the anterior commissure , cannot be excluded its microinfilration.
CONCLUSIONS : In patients with T2DM and no history of coronary artery disease , vit-D deficiency is independently associated with impaired global longitudinal strain.
CONCLUSIONS : In PD , TL is shorter in presence of high oxidative stress as measured by carbonyl protein levels.
CONCLUSIONS : In Poland , male aging is accompanied by an increase in the severity of depressive symptoms.
CONCLUSIONS : In population of Polish men with prediabetes we observed high prevalence of LOH.
CONCLUSIONS : In postmenopausal women , free TFPI increases as vascular wall function deteriorates and PP increases.
CONCLUSIONS : In quinquagenerians , long-term survival after stentless porcine xenograft aortic root replacement is equivalent to that after a mechanical Bentall procedure.
CONCLUSIONS : In resource-poor settings , brief frailty screening assessments may be a useful way of identifying those most in need of support.
CONCLUSIONS : In selected patients , outpatient THA , TKA , and UKA can be performed safely and effectively.
CONCLUSIONS : Insertion of middle images with parallax can extend the fusion limit.
CONCLUSIONS : Insignificant but consistent effects on survival and the dynamics of functional competence suggest effectivity of the complex intervention.
CONCLUSIONS : In stroke rehabilitation , the patients ' motor patterns according to the synergies strongly relate with functional outcomes and are important outcome predictors.
CONCLUSIONS : Insulin resistance in obese individuals may begin as an adaptive mechanism and can be beneficial if it is not associated with glucose dysmetabolism.
CONCLUSIONS : In summary , obesity is associated with decreased serum folate , which parallels decreased folate intakes.
CONCLUSIONS : In summary , the ECG in apparently healthy asymptomatic subjects identifies subgroups at high risk of cardiovascular diseases.
CONCLUSIONS : In summary , this indicates that protein glycation behaves like a double-edged sword.
CONCLUSIONS : In summary , this study offers insight into the therapeutic potential of microglial immune response in AD.
CONCLUSIONS : In Taiwan , a gender difference and age and period effects on the invasively-treated incidence of LE PAD were observed.
CONCLUSIONS : Intake of ≥22 drinks / week before pregnancy was associated with lower mean full scale IQ , overall attention and sustained attention.
CONCLUSIONS : Integrated general medical and psychiatric illness self-management interventions appear feasible and acceptable , with high potential for clinical effectiveness.
CONCLUSIONS : Intensified , NT-proBNP-guided therapy did not improve the primary end point compared with symptom-guided therapy but did improve HF hospitalization-free survival.
CONCLUSIONS : Interaction of age and diffuse subcortical damage are major determinants for poor cognitive performance among stroke patients.
CONCLUSIONS : Intergenerational exposure to low education levels may increase central obesity and type @number@ diabetes differentially among US-born and foreign-born Latinos.
CONCLUSIONS : Intergenerational programs with preschool children brought smiles and conversation to older adults.
CONCLUSIONS : In terms of the relationships between eLBM , ECV , and weight , children are similar to adults.
CONCLUSIONS / INTERPRETATION : Childhood SH was not associated with EEG abnormalities in young type @number@ diabetic adults.
CONCLUSIONS / INTERPRETATION : Decreased mitochondrial oxidative capacity can also occur independently of age in insulin-resistant young obese humans.
CONCLUSIONS / INTERPRETATION : Increased mitochondrial substrate sensitivity is seen in skeletal muscle from type @number@ diabetic patients and is confined to non-lipid substrates.
CONCLUSIONS / INTERPRETATION : Our finding that physical activity attenuates IR during mid-adolescence may be clinically important.
CONCLUSIONS / INTERPRETATION : Physical activity and cohabitation status moderate the link between diabetes mellitus and cognitive performance.
CONCLUSIONS / INTERPRETATION : Pioglitazone treatment up-regulates telomerase activity , telomere-stabilizing proteins and reduces senescence markers in vascular cells.
CONCLUSIONS / INTERPRETATION : The pancreas does not appear to be another target organ for abnormal endocrine function because of ectopic parenchymal fat storage.
CONCLUSIONS : Interventions to identify and support aging veterans with perceived sleepiness should be developed and carefully evaluated.
CONCLUSIONS : Intervertebral disc degeneration occurs where there is a loss of homeostatic balance with a predominantly catabolic metabolic profile.
CONCLUSIONS : Interview- and chart-based methods have specific strengths for identification of delirium.
CONCLUSIONS : In the contemporary era , increasing age is independently associated with postoperative mortality after major hepatic resection at high volume academic centers.
CONCLUSIONS : In the elderly , low mitochondrial oxidative capacity likely results from age-related effects acquired during life span.
CONCLUSIONS : In the elderly , telomere shortening limits hematopoiesis capacity to a very limited extent.
CONCLUSIONS : In the general population , obesity appears to be the most important risk factor for LAE.
CONCLUSIONS : In the massive weight loss population , there are common techniques that can enhance results.
CONCLUSIONS : In the medium-term , elevated BP is not associated with accelerated GFR decline in the general middle-aged population.
CONCLUSIONS : In the north of Portugal , elder homicide seems to be uncommon.
CONCLUSIONS : In the oldest patients aged @number@ ? who suffered from CHF , the incidence of atrial fibrillation and annual mortality was high.
CONCLUSIONS : In the presence of CKD there is a significant association between shorter RTL and CVD manifestations.
CONCLUSIONS : In the present analyses time spent in vigorous-intensity activity declined in later life.
CONCLUSIONS : In the present cohort of dialysis patients , sKlotho was not independently associated with CVD.
CONCLUSIONS : In the revised criteria , a conceptual distinction is made between AD pathophysiological processes and clinically observable syndromes.
CONCLUSIONS : In these @number@ cohorts the observed changes in voiding parameters suggest that detrusor contractility and efficiency decrease with age.
CONCLUSIONS : in the study presented in this article , statistically significant relationships between BPH and the diagnostic parameters of the metabolic syndrome were demonstrated.
CONCLUSIONS : In this age group , the specificity of ADC was found superior to that of the CDC.
CONCLUSIONS : In this analysis , the survival benefit of the ICD exists but is attenuated with increasing age.
CONCLUSIONS : In this Chicago Chinese population , older adults had reasonable levels of health literacy in Chinese.
CONCLUSIONS : In this clinical evaluation , we found no relationships between p16INK4a expression and cytokines , or cytokines and intracellular nucleotide concentrations.
CONCLUSIONS : In this community-based sample , greater subclinical atherosclerotic calcification was associated with worse psychomotor speed and memory in midlife.
CONCLUSIONS : In this cross-sectional community-based study , we found DAo plaque is associated with accelerated brain aging.
CONCLUSIONS : In this cross-sectional study , cortical thickness showed a pronounced age-associated decrease , and the cortical buckling ratio showed a strong age-associated increase.
CONCLUSIONS : In this cross-sectional study , greater time spent in light intensity activity and lower sedentary times were associated with lower BMI.
CONCLUSIONS : In this cross-section study , carriers of the G2019S LRRK2 mutation endorsed subtle nonmotor symptoms.
CONCLUSIONS : In this large observational study we found no benefit of abciximab treatment in elderly high-risk ACS patients who underwent PCI.
CONCLUSIONS : In this large sample of oldest old women , @percent@ had clinically adjudicated cognitive impairment.
CONCLUSIONS : In this paper , we have presented a CS-based reconstruction framework that combines several acceleration techniques.
CONCLUSIONS : In this pilot study , AFP improved pigmentary and textural components of photoaged skin.
CONCLUSIONS : In this population , adherence to the Mediterranean diet showed no significant change over the last @number@ years.
CONCLUSIONS : In this post hoc analysis , similar treatment effects were measured by the full SIB and the SIB-8.
CONCLUSIONS : In this prospective examination , negative affect and attitudes were not associated with subsequent hysterectomy.
CONCLUSIONS : In this prospective population-based cohort study , cognitive test scores among hypercholesterolemic elders declined more slowly than observed in their non-hypercholesterolemic counterparts.
CONCLUSIONS : In this review , older adults with hypertension had decreased cardiovascular morbidity and mortality with antihypertensives compared with no treatment.
CONCLUSIONS : In this sample of older homeless adults , substance use is common.
CONCLUSIONS : In this select population of patients , the identification of the IRA by CA was incorrect in @percent@ of patients presenting with STEMI.
CONCLUSIONS : In this series , ITPR1 deletions were rare and accounted for approximately @percent@ of all autosomal dominant cerebellar ataxias.
CONCLUSIONS : In this small registry of patients with SAH , the age of transfused PRBCs was not associated with adverse events or outcomes.
CONCLUSIONS : In this study a significant diurnal variation of choroidal thickness was not observed.
CONCLUSIONS : In this study low serum levels of potassium were associated with a higher risk of atrial fibrillation.
CONCLUSIONS : In this study , we propose age-specific reference ranges for LVSIsys and LVSIdia.
CONCLUSIONS : In this well-defined cohort receiving state-of-the-art therapy , cognitive performance did not decrease over @number@ years.
CONCLUSIONS : Intradermal RF treatment prior to HA filler injection may provide synergistic and long-lasting effects for the reduction of NLF wrinkles.
CONCLUSIONS : Introducing QIV into the US immunization program may prevent a substantial number of hospitalizations and deaths.
CONCLUSIONS : In women aged @number@ to @number@ years , the rod-like and plate-like Tb.Th of the vertebral body decreased , while Tb.Sp increased.
CONCLUSIONS : In women only , both IGT and T2DM were inversely associated with bone macroarchitecture and measures of bone mineralization and bending strength.
Conclusions : In young adults , an afternoon nap benefits episodic memory retention , but such benefits decrease with advancing age.
CONCLUSIONS : IOL-Master , Lenstar LS900 and AC OCT proved to be excellent non-contact measurement methods in eyes with age-related cataract.
CONCLUSIONS : IOP decreased significantly with age.
CONCLUSIONS : IOP increases significantly when patients are placed in the steep Trendelenburg position.
CONCLUSIONS : I propose that DNA methylation age measures the cumulative effect of an epigenetic maintenance system.
CONCLUSIONS : Ireland's population will experience rapid growth over the next decade.
CONCLUSIONS : Iron-deficiency anemia impaired psychomotor development during childhood.
CONCLUSIONS : Issues related to aging such as changes in sexual relationships , comorbidities , and partner illness complicated the women's breast cancer experience.
CONCLUSION : Sitagliptin has a durable effect and stabilizes microvascular complication progression in elderly patients.
CONCLUSIONS : It appears that the needs for telemedicine health services increased along with the aging of our society in rural and underserved regions.
CONCLUSIONS : It appears there are changes in knee kinematics that occur with aging.
CONCLUSIONS : It appears there was no extreme longevity or Blue Zone in Es Migjorn Gran and the surrounding villages in Menorca.
CONCLUSIONS : It cannot be assumed all individuals benefit equally from auditory cues.
CONCLUSION : Sites treated with three injections of ABO showed no statistically significant difference from those treated with one injection.
CONCLUSIONS : It is evident that most people would give priority to the young over the old in distributing a given amount of healthcare services.
CONCLUSIONS : It is feasible to utilise data visualisation methods developed in biometrics to look at CKD data.
CONCLUSIONS : It is imperative for nurse educators to improve the gerontological nursing clinical practice environment for student nurses.
CONCLUSIONS : It is important to understand the factors that increase and limit late fertility.
CONCLUSIONS : It is possible to extract mRNA of sufficient standard for further transcriptomic analysis from minute FFPE samples up to @number@ years old.
CONCLUSION : Sitting for a long time has a negative influence on physical fitness among postmenopausal women independently of walking time.
CONCLUSION : SIVD patients are able to profit from emotional information in order to enhance their memory performance.
CONCLUSION : Six weeks of unsupervised Wii balance training is an effective modality for improving balance in independent older adults.
CONCLUSIONS : JAK2V617F mutation is more common in old than in young patients with MPD.
CONCLUSIONS : Job strain expressed mainly as low job control is linked to poorer episodic memory at retirement and more decline after retirement.
CONCLUSIONS : Judiciously selected livers from aged donors are not associated with major increased susceptibility to ischaemia reperfusion injury.
CONCLUSION : Skin aging , body site and environmental exposure can affect the SC barrier function , its structure , and its lipid content.
CONCLUSIONS : Kinematic viscometry could be a valid tool to evaluate salivary viscosity.
CONCLUSION : Skin's multilayer structure should play a major role in the appearance of large wrinkles on human skin via its post-buckling behavior.
CONCLUSION : Skipping breakfast is associated with an increased odds of prevalent noncoronary and generalized atherosclerosis independently of the presence of conventional CV risk factors.
CONCLUSIONS : Klotho levels are low in the acute stage of AN and increase with nutritional rehabilitation.
CONCLUSION ( S ) : Knowledge regarding ovulation , fertility , and conception is limited among this sample of reproductive-age US women.
CONCLUSIONS : Known FRIDs , such as psychotropic drugs , also increase the risk of recurrent falls.
Conclusions : L5 induces adipose inflammation through LOX-1 by promoting macrophage maturation and infiltration into adipose tissue.
CONCLUSIONS : Lamina cribrosa depth should be measured from an anterior sclera reference plane to reduce the influence of choroidal thickness changes.
CONCLUSIONS : Laryngeal mask airway placement before an IV is a safe alternative to the usual mask-IV-laryngeal mask airway sequence.
CONCLUSIONS : Laser toning with low fluence Q-switched @number@ nm Nd : YAG laser for skin rejuvenation and melasma can be associated with mottled depigmentation.
CONCLUSIONS : Late GI toxicities are more common than previously reported.
CONCLUSIONS : Late hospice referral in PMBT is common.
CONCLUSIONS : Late-life depression seems to maintain a pervasive relationship over time with affective aspects of religiousness.
CONCLUSIONS : Late-life depression was associated with subcortical and hippocampal neuronal loss but not with cerebrovascular or Alzheimer pathology.
CONCLUSIONS : Late-life leisure activities protect against cognitive impairment among elderly Chinese people , and the protective effects are more profound for educated elderly.
CONCLUSIONS Late shunt failure is caused by the effects of aging on the shunt , and the complications are different from early shunt failure.
CONCLUSIONS : Laughter in response to one's own vocalisations or those of a conversational partner may be a clinically useful measure in dementia diagnosis.
CONCLUSIONS : LCA is useful for exploring dietary patterns transitions.
CONCLUSION : SLC primary care medical practices serve a population that is older , has significant medical comorbidity , and frequently accesses acute medical care.
CONCLUSIONS : LDLT results in improvement in erectile function.
CONCLUSIONS : Leaders should connect with practice to devise age-sensitive efficiency initiatives that support function-focused care.
CONCLUSION : Sleep alterations , including poor sleep quality and prolonged latency , were related to frailty in institutionalized elderly.
CONCLUSION : Sleep apnea may increase risk of dementia in the absence of APOE ɛ4.
CONCLUSION : Sleep disorders are common in institutionalised older individuals and are not related to sleep duration or decreased by ingestion of hypnotic medications.
CONCLUSION : Sleep disturbance is common in patients undergoing rotator cuff repair.
CONCLUSION : Sleep disturbance was associated with central obesity , lower physical fitness and reduced HRQoL.
CONCLUSION : Sleep side preference was not significantly correlated with the appearance of wrinkles or facial descent.
CONCLUSIONS : Legal frameworks do play both a direct and an indirect role in the lives of people with SCI in Switzerland.
CONCLUSIONS : Leisure participation is positively related to subjective well-being among elderly Chinese , and thus could play a critical role in promoting healthy aging.
CONCLUSIONS : LEMG is a safe procedure with few immediate complications , though it may affect the patient's hemodynamic status by increasing DBP and PR.
CONCLUSIONS : Lens crystallins are expressed in mammalian corneas and cultured corneal cells.
CONCLUSIONS : LERTD and HGRFD weren't reliable and shouldn't be used as outcome variables in older men.
CONCLUSIONS : Less than half of the women in our study population correctly estimated their cardiovascular risk.
CONCLUSIONS : Leu-enriched EAA ingestion after RE may prolong the anabolic response and sensitivity of skeletal muscle to amino acids in older adults.
CONCLUSIONS : Levels of HAS were lower in women compared with men , in all age categories.
CONCLUSIONS : Levothyroxine provided no apparent benefits in older persons with subclinical hypothyroidism.
CONCLUSIONS : LGIMD was found to decrease the NAFLD score in a relatively short time.
CONCLUSIONS : Life satisfaction is associated with subjective health evaluations.
CONCLUSIONS : Lifestyle , including aspirin use , modulates age-associated DNA methylation change in the colonic epithelium and thereby impacts the evolution of cancer methylomes.
CONCLUSIONS : Lifestyle interventions incorporating a PA component can improve weight and various cardiometabolic risk factors in class II and III obese individuals.
CONCLUSIONS : Lifestyle strategies differentially affect IMTG accumulation ; combination of exercise with decreased carbohydrate / increased unsaturated fat proportion intake greatly increase IMTG.
CONCLUSIONS : Lifetime vigorous , but not light-to-moderate , HPA is favorably associated with brachial and femoral compliance , but not DC.
CONCLUSIONS : Limited health literacy is a barrier to participation in England's national , publicly available CRC screening programme.
CONCLUSIONS : Literature-based and professional society guidelines provides clinicians with means optimize efficacy and safety of NSAIDs in clinical practice.
CONCLUSIONS : Liver regeneration after PVO is not impaired by age.
CONCLUSIONS : Liver resection can be performed in patients aged ≥70 years as safely as in younger patients.
CONCLUSIONS : Liver transplantation is associated with shortened telomere length in peripheral blood lymphocytes , suggesting accelerated senescence.
CONCLUSIONS : Living alone is associated with elevated mortality , especially among men and an increased risk of institutionalization.
CONCLUSIONS : Lobar microbleeds , a marker of cerebral amyloid angiopathy , are associated with an accelerated rate of executive function decline.
CONCLUSIONS : Locally elevated perihematoma PS was found in most spontaneous basal ganglia ICH patients within @number@ to @number@ h after symptom onset.
CONCLUSIONS : Loneliness is a significant predictor of anorexia nervosa , the risk of malnutrition and malnutrition.
CONCLUSIONS : LONG compared to SHORT surface translations magnify the age-related kinematic but not the EMG changes in reactive postural control.
CONCLUSIONS : Longitudinal data analysis requires handling not only serial correlation but often also time-varying covariates , missing data , and unknown change points.
CONCLUSIONS : Longitudinal EM changes in cognitively intact , healthy elders can be predicted by disruption of the MTL WM microstructure.
CONCLUSIONS : Longitudinally , Black youth appear to experience disproportionate risks compared with White and Hispanic youth when income is statistically controlled.
CONCLUSIONS : Long-term childhood cancer survivors have poor adherence to the @number@ Dietary Guidelines for Americans.
CONCLUSIONS : Long-term cumulative lead exposure may be weakly associated with faster cognitive decline in community-dwelling women , at least in some cognitive domains.
CONCLUSIONS : Long-term follow-up identified important phenotypic variability in this cohort of @number@ BM patients.
CONCLUSIONS : Long-term follow-up showed higher mortality among elderly subjects affected by CHF or COPD.
CONCLUSIONS : Long-term KT recipients demonstrated a more severe degree of VC compared to matched CKD stages 5-5D patients.
CONCLUSIONS : Long-term smoking and alcohol consumption , although at a low dose , induces CP-like changes.
CONCLUSIONS : Long-term T therapy , at physiological levels , ameliorates MetS components.
CONCLUSIONS : Long-term unemployment in early adulthood is associated with shorter LTL among men.
CONCLUSIONS : Long-term use of benzodiazepine leads to specific impairment in long-term memory only in women.
CONCLUSIONS : Long-term use of PPI occurs in one out of nine individuals in the older population.
CONCLUSIONS : LOS differed between patients admitted through emergency and through elective admission.
CONCLUSIONS : Low ABI ( even borderline ) was independently associated with poor QOL , especially for physical components , in community-dwelling older adults.
CONCLUSIONS : Low ALT levels are associated with increased long-term mortality among middle-aged patients with stable coronary heart disease.
CONCLUSIONS : Low apparent CYP17A1 activity ( assessed with ratio @number@ ) is associated with elevated daytime ABP when salt intake is high.
CONCLUSIONS : Low baseline hemoglobin strongly predicted incident depression in older men , but not in women.​.
CONCLUSIONS : Low baseline PF was an independent common predictor of 2-year WL and WG ≥ @percent@ in the healthy well-functioning community-dwelling elderly population.
CONCLUSIONS : Low childhood subjective socioeconomic status had a robust association with functional limitation regardless of age cohort.
CONCLUSIONS : Low detection rates and low treatment rates need to be addressed.
CONCLUSIONS : Low education and lack of physical activity in late-life may affect the risk for malnutrition in the elderly.
CONCLUSIONS : Low eGFR is associated with reduced performance on executive function.
CONCLUSIONS : Lower adherence to the MeDi in an older Scottish cohort is predictive of total brain atrophy over a 3-year interval.
CONCLUSIONS : Lower aldosterone levels in Blacks did not translate into higher K + concentrations.
CONCLUSIONS : Lower anterior and posterior isometric and swallowing tongue strength were dependent on aspiration status.
CONCLUSIONS : Lower childhood IQ is associated with an increased risk of cardiovascular events in adulthood , even after adjustment for confounding variables.
CONCLUSIONS : Lower CH was associated with HRT and GDxVCC parameters in a direction that is seen in glaucoma and with ageing.
CONCLUSIONS : Lower education level is an independent predictor of incident preclinical mobility disability.
CONCLUSIONS : Lower grip strength was independently associated with dementia in the older adult population in Singapore.
CONCLUSIONS : Lower health literacy increases the risk of exhibiting faster physical decline over time among older adults.
CONCLUSIONS : Lower intakes of vegetables and legumes were associated with cognitive decline among illiterate elderly Chinese.
CONCLUSIONS : Lower lifetime intake of fiber during the course of young age is associated with carotid artery stiffness in adulthood.
CONCLUSIONS : Lower physical activity predicted worse cognition and cerebral perfusion @number@ months later in HF.
CONCLUSIONS : Lower serum bicarbonate was associated with greater risk of incident , persistent functional limitation.
CONCLUSIONS : Low executive function is potentially a barrier to self-care , the cornerstone of managing blood glucose levels.
CONCLUSIONS : Low handgrip strength , a simple and inexpensive test could be considered in clinical settings for identifying future falls and fractures.
CONCLUSION : Slowing down may have low sensitivity for identifying fatigability in older persons , but ascertaining perceived exertion during a defined workload shows promise.
Conclusion : Slowing in processing abilities accounts for the primary trajectory of age-related declines in verbal working memory.
CONCLUSIONS : Low iron levels are associated with increased levels of both cFGF23 and iFGF23 , independent of low grade inflammation.
CONCLUSIONS : Low levels of testosterone are associated with a risk for dementia in elderly men.
CONCLUSIONS : Low levels of TT , SHBG and AR may be potential risk factors for DM in elderly men.
CONCLUSIONS : Low or extremely high BMI , independent of its metabolic consequences , is a risk factor for disability among the elderly.
CONCLUSIONS : Low PRL is related to several metabolic , psychological , and sexual unhealthy characteristics in European men.
CONCLUSIONS : Low serum testosterone concentration may be a modifiable risk factor for adverse outcomes and poor quality of life in male hemodialysis patients.
CONCLUSIONS : Low SES was associated with greater WM pathology-a marker for increased stroke risk-in AAs.
CONCLUSIONS : Low thiamine levels are associated with elevated blood glucose and hypertension in Saudi adults.
CONCLUSIONS : low visual contrast sensitivity , poor knee extensor strength and significant depressive symptoms are independent determinants of future onset of mobility disability.
CONCLUSIONS : Low vitamin B-6 concentrations are associated with inflammation , higher oxidative stress , and metabolic conditions in older Puerto Rican adults.
CONCLUSIONS : LTL is most strongly associated with adiposity , but is also associated with biomarkers across several physiological systems.
CONCLUSIONS : LT was observed in about one in four MTOPS study participants with baseline TT measurements.
CONCLUSIONS : Lumbar lordosis decreases as position changes from standing to 90°sitting.
CONCLUSIONS : Lumbar retrolisthesis , together with thoracolumbar kyphosis , appears to be associated with mechanisms associated with regulation of sagittal balance.
CONCLUSIONS : LVDD is common in this community elderly population , and HFpEF is also not rare.
CONCLUSIONS : LZ / BB-based dyes are suitable for DMEK with outcomes comparable to TB.
CONCLUSIONS : Magnesium is capable of increasing the efficacy of immunoneutralization of marinobufagenin-induced Na / K-ATPase inhibition.
CONCLUSIONS : Maintaining or restoring the low oxygen partial pressure around that lens should decrease or prevent nuclear cataracts.
CONCLUSIONS : Major abdominal surgery decrees efficiency of walking and lung ventilation after @number@ year old in early postoperative period.
Conclusions : major depression was associated with worse executive function across the lifespan , but minor depression only in younger adults.
CONCLUSIONS : Majority of the oldest-old in China rated their life satisfaction as good or very good.
CONCLUSIONS : Male subjects with LDD have a higher osteoporotic fracture risk , in spite of systemically higher BMD.
CONCLUSIONS : Malignant PNETs is the proper indication for surgical treatments.
CONCLUSION : Small magnitude , statistically significant increases in total retinal thickness and retinal layer thickness occur from early childhood to adolescence.
CONCLUSIONS : Malnutrition in the older hospital population is common.
CONCLUSIONS : Many elderly individuals with dementia do not receive clinical cognitive evaluations.
CONCLUSIONS : Many geriatric conditions were not associated with risk of ADRs.
CONCLUSIONS : Many hospital readmissions after an ED visit may be preventable by identifying caregiver's high burden.
CONCLUSIONS : Many older Australians lack knowledge of STIs and safer sexual practices.
CONCLUSIONS : Many PFAS compounds are decreasing in a sample of Gullah African Americans from coastal South Carolina.
CONCLUSIONS : Many retirees rely on superannuation to fund their retirement.
CONCLUSIONS : Markers of physical and mental fitness are associated with the epigenetic clock ( lower abilities associated with age acceleration ) .
CONCLUSIONS : Markers of physical function-walking speed and grip strength-were consistently associated with survival and recovery after ischemic stroke.
CONCLUSIONS : Maximal reach but not error in perceived reach is associated with falls in older people.
CONCLUSIONS : Maximum rate of finger tapping was lower in the elderly adults compared with the young adults.
CONCLUSIONS : MCI and AD subjects showed a decreased sleep instability correlated with their cognitive decline.
CONCLUSIONS : MCI cases , including those who revert to CN , have a high risk of progressing to dementia.
CONCLUSIONS : MCI is associated with doing less housework.
CONCLUSIONS : MCR subtypes based on individual gait parameters show commonalities and differences in cognitive profiles and risk factors.
CONCLUSIONS : MDRB-related VAP is associated with prolonged ICU stay and mechanical ventilation.
CONCLUSIONS : Mean delay time from objective POP diagnosis until decision concerning surgical treatment was more than @number@ years.
CONCLUSIONS : Mean WAI score found in Israeli hospital nurses is relatively high as compared with that of European nurses.
CONCLUSIONS : Measurements per se might interact with the skin , thus changing its characteristics.
CONCLUSIONS : Measuring MTDSA by ultrasound facilitates selection of the appropriate ETT in pediatric patients and may reduce the number of reintubations.
CONCLUSIONS : Measuring SRH by an index of deficits is a valid construct and is associated with adverse health outcomes.
CONCLUSIONS : Mechanic and pragmatic cognitive functions may serve differently as moderators of the relation between age and technology ownership.
CONCLUSION ( S ) : Median and mean AMH levels decreased steadily with increasing age from @number@ to @number@ years of age.
CONCLUSIONS : Medicare beneficiaries with cancer are less responsive to the presence and type of supplemental insurance than are beneficiaries without cancer.
CONCLUSIONS : Medication adherence rate was relatively low among hypertensive subjects.
CONCLUSIONS : Meeting the recommended PA guidelines pre- and post-MI may have a protective role against mortality in postmenopausal women.
CONCLUSIONS : Men are at greater risk of developing incident brain infarcts than women.
CONCLUSIONS : Men presumed being testosterone deficient had a higher symptom score , in particularly regarding anxiety , but they did not have pathological symptoms.
CONCLUSIONS : Mental and physical health conditions have very similar associations with sexual inactivity in men and women.
CONCLUSIONS : Mental disorders in older prisoners are common , but despite recent training initiatives they often go undetected and untreated.
CONCLUSIONS : Men with IIH are more likely than controls to have symptoms associated with testosterone deficiency and OSA.
CONCLUSIONS : Mesalazine treatment was not superior than placebo on the study primary endpoint.
CONCLUSIONS : Metabolic dysregulation predicts a poor course of late-life depression.
CONCLUSIONS : Metabolic profile provides prognostic value for HF patients better than Gal-3.
CONCLUSIONS : Metabolic syndrome and its two key components , high BP and diabetes were associated with age-related cataract.
CONCLUSIONS : Metabolic syndrome is associated with subclinical carotid plaque among Chinese elderly people , driven primarily by elevated blood pressure and hyperglycemia.
CONCLUSIONS : Metabolic syndrome was not associated with cognitive impairment in this population.
CONCLUSIONS : Metabolomics demonstrate powerful diagnostic value in estimating HF-related metabolic disturbance.
CONCLUSIONS : Metformin has a positive effect on glucose homeostasis during exercise.
CONCLUSIONS : Metformin slowed ARC development in old men with T2D , and these effects varied by ARC phenotype.
CONCLUSIONS : Metformin use was associated with impaired cognitive performance.
CONCLUSIONS : Methamphetamine users appear to show increased cortical gray matter loss with age which raises the possibility of accelerated decline in mental functioning.
CONCLUSION ( S ) : Methodological changes had a strong effect on the percentage of morphologically normal spermatozoa over the past few decades.
CONCLUSIONS : Metric and scalar invariance across HE and LE samples was achieved for seven of the @number@ tests in the CSHA battery.
CONCLUSIONS : MetS is associated with worse cognitive function among younger elderly.
CONCLUSIONS : mFI is not a predictive of post-penile prosthesis implantation adverse outcomes in elderly patients with impotence.
CONCLUSIONS : MGT-CDUS is a useful tool in detecting abnormalities related to impaired male reproductive health.
CONCLUSIONS : Microinfarcts , which have been correlated with severity of cognitive impairment , were most strongly associated with atherosclerosis.
CONCLUSIONS : Middle-aged workers are equally as likely to experience MC as non-working age-peers.
CONCLUSIONS : Midlife metabolic diseases , especially diabetes , are independently associated with impaired cognition in old age.
CONCLUSIONS : Mild tremor is common in children and covaries significantly with several demographic and clinical factors as well as usage of certain medications.
CONCLUSIONS : Minor trauma and solar elastosis from chronic ultraviolet radiation exposure are likely the etiologic factors in the development of lymphostasis.
CONCLUSIONS : Mitochondrial failure in the joint is able to reproduce the oxidative and inflammatory status observed in arthritic joints.
CONCLUSIONS : Mixed evidence has been found for the association of psychological factors in association with FrPCs.
CONCLUSIONS : Mixed or a higher load of CMBs , with some specificity for location , is associated with accelerated cognitive decline in older people.
CONCLUSIONS : Models are presented for expected 2-dimensional sonographic lung size parameters and their variance as a function of menstrual age.
CONCLUSIONS : Models based on a widely available data achieve very good validity for predicting ADL dependence.
CONCLUSIONS : Moderate to severe ADAM and LUTS impact significantly all parameters of HRQOL and generic QoL proposed by the WHO.
CONCLUSIONS : Modifiable dietary and lifestyle predictors of serum 25 ( OH ) D were identified in African Americans.
CONCLUSIONS : Modified toy cars have serious potential to be a fun and functional power mobility option for children with special needs.
CONCLUSION : Smoking , family history of PHG , and obesity are important factors associated with PHG.
CONCLUSIONS : More attention should be paid to prevent perioperative arrhythmia in the elderly lung cancer patients.
CONCLUSIONS : More informal than formal care was provided.
CONCLUSIONS : More open debates of practical experiences from different trial centres and sponsors are essential for optimizing trial designs and improving conditions for participants.
CONCLUSIONS : More than half the population aged @number@ years has a vitamin D deficit and @percent@ show a deficiency.
CONCLUSIONS : More than @number@ in @number@ HIV-infected MSM US veterans reported consistent , long-term hazardous alcohol use.
CONCLUSIONS : More than @percent@ of the population was infected with either agent.
CONCLUSIONS : More than two thirds of the advanced elderly report impairment of health status.
CONCLUSIONS : Most infants who cry a lot at 5-6 weeks of age ' sleep through the night ' at @number@ weeks of age.
CONCLUSIONS : Most markers of progression of CSVD over time and some markers of baseline CSVD are associated with concurrently developing new depressive symptoms.
CONCLUSIONS : Most of elderly patient are fit to undergo standard treatment and can get the same benefits of younger women.
CONCLUSIONS : Most of the women during menopausal transition had climacteric symptoms , usually mild and moderate ones.
CONCLUSIONS : Most older adults who received rehabilitation reported functional improvement and meeting rehabilitation goals.
CONCLUSIONS : Most older breast cancer patients are robust and could consider chemotherapy where otherwise indicated.
CONCLUSIONS : Most people reporting spinal pain manage without any serious consequences.
CONCLUSIONS : Most residents were insufficiently active to gain health benefits.
CONCLUSIONS : Most respondents feel younger than their chronological age , the more the older they are.
CONCLUSIONS : Most studies focused on nurse assisted home care patients on dialysis.
CONCLUSIONS : Most symptoms and diseases thought to be associated with TDS are primarily age dependent.
CONCLUSIONS : Motoric cognitive risk syndrome is associated with low global cognitive performance.
CONCLUSIONS : MOVES is a holistic measure of mobility for characterizing older adult mobility across populations.
CONCLUSIONS : MP-1 microperimetry examination could be used to evaluate the macular retinal function.
CONCLUSIONS : MPOD levels showed a high degree of intraindividual concordance and interindividual variability.
CONCLUSIONS : MPTs were longer in this group of older adults than previously reported and did not vary significantly with age or gender.
CONCLUSIONS : MRI T2 / FLAIR overestimates periventricular and perivascular lesions compared to histopathologically confirmed demyelination.
CONCLUSIONS : MRSA constitutes a significant epidemiological problem in cases of hospital-treated pneumonia.
CONCLUSIONS : MRS is a useful and reproducible technique to study bone marrow fat in CKD.
CONCLUSIONS : MSC therapy with TESI in ICM patients improves 6MWD and MLHFQ score and reduces myocardial infarction size.
CONCLUSIONS : MS does not impose more AF risk in elderly hypertensive patients.
CONCLUSIONS : MTHFR1298AC gene heterozygous polymorphisms can be weakly predictive for NAFLD severity.
CONCLUSIONS : mTOR signalling plays a crucial role in the osteoblastic differentiation of VSMCs.
CONCLUSIONS : MUC5AC might be affected by chronic H. pylori infection.
CONCLUSIONS : Multimorbidity is a global phenomenon , not just affecting older adults in HICs.
CONCLUSIONS : Multimorbidity is associated with systemic OxS but only in elderly people with either no or mild cognitive impairment.
CONCLUSIONS : Multiple candidate genes related to lipoprotein and vitamin K metabolism were identified as potential determinants of circulating phylloquinone.
CONCLUSIONS : Multiple declines in QOL occur after stroke , and social isolation heightens risk for increasing depression after stroke.
CONCLUSIONS : Multiple physical diseases were linked to increased risks of suicide in older adults.
CONCLUSIONS : Muscle-bone interaction was changed in elderly , especially in those with osteoporosis.
CONCLUSIONS : Muscle density may serve as a physiological marker in the assessment of lower leg muscular health and fall risk in community-dwelling elderly women.
CONCLUSIONS : Muscle force of ( A ) upper limb after stroke demonstrates a @percent@ decrease.
CONCLUSIONS : Muscle loss in advanced cancer is related to age , sex , tumor type , and inflammation.
CONCLUSIONS : Muscle strength was significantly correlated with muscle mass in both age groups in men.
CONCLUSIONS : Muscle weakness was associated with an increased rate of diabetes in older male and female Mexican Americans.
CONCLUSIONS : Myofibromas may resemble several other entities.
CONCLUSIONS : Narrow phase angle is associated with frailty and mortality independent of age and comorbidity.
CONCLUSIONS : Naturally postmenopausal women with higher remaining estradiol levels appear less likely to suffer from kidney calcium oxalate stones.
CONCLUSIONS : Near elderly persons with better mobility had higher quality of life.
CONCLUSIONS : Nearly all new patients presenting for gynecologic oncology consultation answered self-administered items to assess sexual activity and function.
CONCLUSIONS : Nearly one-fifth of older men drank heavily or excessively.
CONCLUSIONS : Nearly @percent@ of Medicare beneficiaries , especially men , had life expectancies < 10 years at the time of screening colonoscopies.
CONCLUSIONS : Neck pain is a common condition that causes substantial disability.
Conclusions : Negative surgical margin was associated with better survival.
CONCLUSIONS : Neighbourhood CHC in urban areas provides important services to these residents living in a recently urbanised community.
CONCLUSIONS : Nephrotic syndrome was the major indication for renal biopsy , and membranous nephropathy was the most frequent diagnosis.
CONCLUSIONS : Neuropsychiatric symptoms among those with CIND or dementia are associated with a significant increase in the provision of informal care.
CONCLUSIONS : Neuroticism was associated with medication non-adherence over @number@ years of follow-up in a large sample of older RCT participants.
CONCLUSIONS : never smokers and regular exercisers had substantially reduced odds of 7-year disability onset.
CONCLUSIONS : New-generation AEDs were administered to most of the patients in this outpatient clinic-based cohort of older patients with epilepsy.
CONCLUSIONS : New-onset diabetes in older adults is associated with an increased risk of mortality , and hypoglycemia is an important marker of this association.
CONCLUSIONS : New sarcopenia definition by FNIH was better able to predict 6-year mortality among Korean men.
CONCLUSIONS : NFT deposition , vascular lesions , and high NPC scorewere associated with cognitive impairment in a unique Brazilian sample with low education.
Conclusions : NGS was robustly associated with both cardiometabolic disease risk and physical disabilities in U.S. and Chinese aging adults.
CONCLUSIONS : NIH funding for diagnostic radiology departments has largely been awarded to senior-ranking male PhD investigators , commonly at large major academic medical centers.
CONCLUSIONS : NLTPA is an independent predictor of longevity among older people in Taiwan.
CONCLUSIONS : no accurate method to evaluate renal function in the elderly was found.
CONCLUSIONS : No age-related increases and no differences between the Japanese and the US subgroups were found with regard to PZ volume.
CONCLUSIONS : Nocturia and poor sleep are common among women with diabetes.
CONCLUSIONS : No declines were observed in the prevalence of activity limitations in the Dutch older population over the period 1990-2007.
CONCLUSIONS : No evidence was found that current use of BPs increases the risk of severe upper gastrointestinal complications compared to past use.
CONCLUSIONS : No impact of testosterone was found on the PSA level in healthy men with PSA < 4 ng / mL.
CONCLUSIONS : Nonablative fractionated laser resurfacing induces a well-organized wound-healing response that leads to substantial dermal remodelling and collagen induction.
CONCLUSIONS : Non-adherence to cardiovascular medications is a serious problem in the aging Australian setting with an overall prevalence of between @number@ and @number@ %.
CONCLUSIONS : Non-crosslinked intact PADM yielded favorable early outcomes when used to repair complex ventral abdominal wall hernias in high-risk patients.
CONCLUSIONS : Non-motor symptoms have a significant impact on psychological well-being in PD patients.
CONCLUSIONS : Non-sequential fractional ultrapulsed CO₂ laser resurfacing ( ActiveFX ) is considered an excellent treatment modality for photodamaged Chinese facial skin.
CONCLUSIONS : Normal eyelid contour in Asians was the shape of an arch that has higher temporal lid contour than the nasal one.
CONCLUSIONS : Normalized T-cell subsets were observed in approximately one-third of geriatric HIV-positive subjects , and they were predicted by female sex and immunovirological features.
CONCLUSIONS : Normalizing serum T in men with LOH resulted in improvement of the metabolic syndrome , mood and sexual functions and appeared acceptably safe.
CONCLUSIONS : Normal weight participants had elevated mortality risk compared with overweight participants.
CONCLUSIONS : Normative hand strength values need to be further assessed in a larger study to update normative standards for use in clinical practice.
CONCLUSIONS : No significant changes in RAL exposure associated with age were observed.
CONCLUSIONS : No single pathologic entity strongly dichotomized MCI groups , perhaps due to the pathologic heterogeneity found within both entities.
CONCLUSIONS : Not MCI , but objective cognitive impairment alone , is the best predictor for progression to dementia in a community sample.
CONCLUSION : SNs have a high incidence in individuals without persistent lumbar disorders and were found in disks at all degrees of degeneration.
CONCLUSIONS : ( @number@ ) F-florbetaben Aβ imaging facilitates accurate detection of prodromal AD.
CONCLUSIONS : numerous barriers exist to the provision of high-quality palliative care for older people within acute hospital settings.
CONCLUSIONS : Nurses ' descriptions highlight the need for increased communication , staff education and availability of palliative care services.
CONCLUSIONS : Nurses will play a vital role in the future design and delivery of high-quality cancer care.
CONCLUSIONS : Nursing home closures are geographically concentrated in minority and poor communities.
CONCLUSIONS : Nursing students ' knowledge on pressure ulcer prevention was relatively low.
CONCLUSIONS : Nursing workload of 12-hour shifts has a negative physiological impact on hospital nurses.
CONCLUSIONS : Nutritional intervention , even dietary counseling without nutritional supplements , may improve nutritional status.
CONCLUSIONS : Nutritional risk was associated with all-cause hospitalizations , nonsurgical hospitalizations , and mortality.
CONCLUSIONS : Nutritional self-care promotion is of pivotal importance for the nursing care provided to home-dwelling older people.
CONCLUSIONS : OABSS is a useful tool in assessing AD patients with LUTS.
CONCLUSIONS : OACs , as opposed to antiplatelets , predispose to lobar location of brain hematomas according to a dose-response relationship.
CONCLUSIONS : OA negatively affected physical performance 3-6 years after it was first reported.
Conclusions : Obese older adults may require targeted interventions and additional support to improve their daily activity levels.
Conclusions : Obesity is not associated with incident mobility or ADL disability in nonagenarians.
CONCLUSIONS : Objective tests were well accepted and feasible to perform , although not all are suitable for widespread clinical or research use.
CONCLUSION : Social isolation and loneliness show different associations with changes in evaluative and hedonic well-being over time.
CONCLUSION : Social isolation is associated with greater risk of hospitalization and death in HIV + and uninfected older veterans.
CONCLUSION : Sociocultural conceptualization of Alzheimer's disease and other dementias is of growing interest in shaping the interpretation of the symptoms of dementing diseases.
CONCLUSIONS : Octo- and nonagenarians seem to tolerate arterial reconstruction relatively well.
CONCLUSIONS : Ocular refraction in rural Chinese adults showed significantly hyperopic shift with age.
CONCLUSIONS : Odor detection threshold scores were worse in older age groups but similar between men and women in this large population of older adults.
CONCLUSIONS : OFE appears to meet the health needs of seniors , but improved management is necessary to ensure safety.
CONCLUSIONS : of the analyzed IOLs had the same colorimetric performance of the human crystalline lens.
CONCLUSIONS : of the investigated bonding concepts of the zirconia-to-resin interface provided clinically sufficient tensile bond strength.
CONCLUSIONS : of the three scores helped in the triage of patients according to their risk of future in-hospital AGE.
CONCLUSIONS : Old age is not a risk factor for incomplete VCE examination and it is associated with increased VCE yield.
CONCLUSIONS : Older Aboriginal people reported falls to be a priority health issue , with a significant impact on their health and well-being.
CONCLUSIONS : Older adults are able to evaluate their own probabilities of severe vitamin D deficiency , deficiency and insufficiency.
CONCLUSIONS : Older adults in Ireland with MHD are more likely to smoke than those without such difficulties.
CONCLUSIONS : Older adults in Singapore have a relatively weak HGS compared to other countries.
CONCLUSIONS : Older adults living in less urbanized areas are more likely to be prescribed psychotropic drugs.
CONCLUSIONS : Older adults require more processing resources to understand speech in noise.
CONCLUSIONS : Older adults show poorer gap detection ability when compared to younger adults.
CONCLUSIONS : Older adults use the ED appropriately also in Italy.
CONCLUSIONS : Older adults were mostly disabled in physical related activities , whereas disability in more cognitive related activities was less often experienced.
CONCLUSIONS : Older adults with both IFG and elevated HbA1c have a substantially increased odds of developing diabetes over @number@ years.
Conclusions : Older adults with cognitive impairment not only have difficulty with competing acoustic signals but may also show poor temporal processing.
CONCLUSIONS : Older adults with FoF overestimate their TUG performance , reflecting impairment in motor planning.
CONCLUSIONS : Older adults with GAD use alcohol at an increased rate , but mild to moderate drinkers do not experience sleep difficulties.
CONCLUSIONS : Older adults with hearing loss or self-reported hearing difficulty are as likely to use most health services as those without hearing loss.
CONCLUSIONS : Older adults with HIV have a reduced risk for non-adherence to ART than their younger counterparts.
CONCLUSIONS : Older adults without driving mobility had poorer cognitive functioning at baseline and experienced accelerated cognitive decline relative to active drivers over follow-up.
CONCLUSIONS : Older adults with specific diseases have risk factors for polypharmacy modifiable by actions aimed at the rational use of medicines.
CONCLUSIONS : Older age , hypertension , and dementia were independently associated with OH in the older adult population in Singapore.
CONCLUSIONS : Older age was associated with poorer performance on Trails A in patients with BD but not healthy adults.
CONCLUSIONS : Older cancer patients strongly differ from middle-aged cancer patients , in particular with respect to coping.
CONCLUSIONS : Older Chinese without diabetes are characterized with worse insulin secretion and better insulin sensitivity.
CONCLUSIONS : Older community-dwelling adults with low serum 25 ( OH ) D levels are at higher risk of all-cause and cardiovascular disease mortality.
CONCLUSIONS : Older listeners had difficulty using periodicity cues to obtain information related to talker fundamental frequency.
CONCLUSIONS : Older New Zealand adults displayed better cognitive function than those in a US sample.
CONCLUSIONS : Older nurses have a wealth of knowledge and expertise , and the design of nursing units can optimize their work experience.
CONCLUSIONS : Older patients admitted for acute care have a higher severity of disease than younger ones.
CONCLUSIONS : Older patients with an increasing number of these factors may not benefit as much from aggressive surgery as patients with fewer factors.
CONCLUSIONS : Older patients with anti-GBM disease had milder kidney damage and less pulmonary involvement.
CONCLUSIONS : older people in rehabilitation and care home settings had lower grip strength than reported for those living at home.
CONCLUSIONS : Older people reporting spinal pain have @percent@ increased risk of mortality per years lived but the connection is not causal.
CONCLUSIONS : Older people with ID report more symptoms of anxiety than older people with normal intelligence.
CONCLUSIONS : Older persons should be supported in their attempts to go outdoors during midwinter.
CONCLUSIONS : Older recurrent fallers are characterized by increased within-task variability in reaction time and stride length while dual-tasking.
CONCLUSIONS : Older women desire information and have more agency and input in the decision-making process than prior literature would suggest.
Conclusions : Older women meeting current recommendations of ≥2.5 h / wk of MVPA , as assessed by accelerometer , had longer LTL.
CONCLUSIONS : Older women who undergo PMBR have better breast-related QOL outcomes than those who do not.
Conclusions : Older women with sleep disturbances have an increased risk of hospitalization partially attributable to demographics , poorer health status , and comorbidities.
CONCLUSIONS : Older workers have different needs than younger ones , especially in the organization and working conditions.
CONCLUSIONS : Older workers may tolerate shift work well.
CONCLUSIONS : Older workers whose physical abilities do not meet job demands face increased injury risk.
CONCLUSIONS : Oldest-old patients are increasingly using ED services.
CONCLUSIONS : Omentectomy conferred improved utility of peritoneal catheters in children.
CONCLUSIONS : OnabotulinumtoxinA delivered for @number@ months significantly reduces or progressively eliminates glabellar rhytides for up to @number@ months after the last treatment.
CONCLUSIONS : One out of five adults over the age of @number@ years experiences discrimination in healthcare settings.
CONCLUSIONS : One third of sepsis survivors were readmitted and wide variation exists between hospitals.
CONCLUSIONS : Only CTCS appeared to have significant incremental predictive value in the U.S. general population , especially in those at intermediate risk.
CONCLUSIONS : On the basis of an analysis of biopsies collected by in the United States , gastric abnormalities increase with age.
CONCLUSIONS : Oocytes with absent spindles were associated with lower fertilization rates and advanced female age.
CONCLUSIONS : Operative mortality with high-risk surgery fell substantially during the previous decade.
CONCLUSIONS : Operative treatment of gelsolin amyloidosis is symptomatic.
CONCLUSIONS : Opportunistic infections and aging diseases were the most frequent causes of death , adding multiple disease burdens on health services.
CONCLUSIONS : Optimal midlife BMI and WC for successful aging might be substantially below the current thresholds used to define obesity.
Conclusions : optimisation of bone health as well as prevention of falls should be considered as strategies to reduce fractures in frail older people.
CONCLUSION : Sorafenib showed similar results in terms of safety and efficacy in the elderly and younger HCC populations.
CONCLUSIONS : Oral bisphosphonates are commonly prescribed by NPs for postmenopausal females with the diagnosis of osteoporosis to arrest bone loss and preserve bone density.
CONCLUSIONS : Oral edoxaban was noninferior to subcutaneous dalteparin with respect to the composite outcome of recurrent venous thromboembolism or major bleeding.
CONCLUSIONS : Oral supplementation with inorganic nitrate did not improve glucose and insulin responses but reduced oxidative stress in old individuals during acute hyperglycemia.
CONCLUSIONS : Oral T3 therapy significantly attenuated the postoperative decline in T3 concentrations in patients undergoing off-pump coronary artery bypass graft surgery.
CONCLUSIONS : OSA is associated with impaired verbal episodic memory and microvascular damage in older adults with depression and cognitive impairment.
CONCLUSIONS : OSAS is prevalent in postmenopausal women , especially in late postmenopause.
CONCLUSIONS : Otolin-1 blood levels are significantly higher in patients older than @number@ years of age.
CONCLUSION : Sound localization performance improved significantly after canaloplasty.
CONCLUSIONS : Our adjusted results do not support the hypothesis that beta blocker use is associated with decreased risk of CRC.
CONCLUSIONS : Our analysis suggested that type @number@ diabetes mellitus is highly prevalent in China.
CONCLUSIONS : Our analysis suggest that obesity is strongly correlated with temporary employment.
CONCLUSIONS : Our changing demographics have had an impact on smoking prevalence over the last @number@ decades.
CONCLUSIONS : Our clinical results indicate that the 3D procedure is an effective nonsurgical skin rejuvenation method.
CONCLUSIONS : Our comprehensive meta-analysis highlighted the genetic contribution to sporadic VaD.
CONCLUSIONS : Our cross-sectional analysis supports suggestions that smoking might contribute to shortening of LTL but this relationship could not be shown longitudinally.
CONCLUSIONS : Our data are consistent with a positive non-linear association between Gal-3 and HF risk in male subjects.
CONCLUSIONS : Our data confirm the need of quality monitoring in stroke care.
CONCLUSIONS : Our data demonstrate modest correlation between measurements of plasma phospholipid fatty acids spaced by @number@ years.
CONCLUSIONS : Our data demonstrate that muscle gains and fat loss after ET are positively related to baseline hyperglycemia.
CONCLUSIONS : Our data demonstrate that serum PSA levels are related to impaired reproductive parameters in middle-aged subjects.
CONCLUSIONS : Our data do not support the use of the widely used L / M ratio as an accurate estimate of intestinal permeability.
CONCLUSIONS : Our data establish the minimal effective concentration of EACA necessary to completely prevent fibrinolysis in neonatal blood in vitro.
Conclusions : Our data indicate that a diet of various healthy foods may be optimal for reducing AMD risk.
CONCLUSIONS : Our data provide a simple means of avoiding unnecessary total IgA measurements in the assessment of coeliac disease.
CONCLUSIONS : Our data provide first evidence for a link between oncogenic JAK2V617F signaling and cell intrinsic induction of CXCL10 induced by activated NFkB signaling.
CONCLUSIONS : Our data showed high prevalence of malnutrition and the risk of its development among the community-dwelling elderly people in Poland.
CONCLUSIONS : Our data show that LRRK2 phosphorylation is reduced with clinical PD , whereas LRRK2 expression is increased in early potential prodromal stages.
CONCLUSIONS : Our data show that T2DM is associated with MCI and MCI subtypes in middle-aged , but not in old-aged participants.
CONCLUSIONS : Our data suggested that reduced intraoperative perfusion as measured using CVP monitoring might increase DGF risk.
CONCLUSIONS : Our data suggests an association between S-Cu and sleep duration in ageing men.
CONCLUSIONS : Our data suggest that BAS is superior to CA in assessing the rate of aging in healthy Chinese people.
CONCLUSIONS : Our data suggest that different cognitive patterns may exist depending on disease severity , possibly indicating differences in pathogenesis.
CONCLUSIONS : Our data suggest that exposure to smoke both prenatally and around the time of menopause accelerates ovarian aging.
CONCLUSIONS : Our data suggest that higher plasma levels of plasma cis-vaccenic acid may be associated with a lower risk of HF with antecedent CHD.
CONCLUSIONS : Our data suggest that HIV infection is a risk factor for HF.
CONCLUSIONS : Our data suggest that moderate consumption of chocolate might be associated with a lower risk of HF in male physicians.
CONCLUSIONS : Our data suggest that radiation-induced mast cell mediators have a tremendous impact on inflammatory cell recruitment into irradiated skin.
CONCLUSIONS : Our data suggest that the role of SHP-1 in T cell activation extends to its increased effect in negative feedback in aging.
CONCLUSIONS : Our data suggest that timing and cell dose of transplantation determine the therapeutic effects after focal ischemia by modulating poststroke neuroinflammation.
CONCLUSIONS : Our data support the concept that serum 25 ( OH ) D concentrations are associated with risk and prognosis of melanoma.
CONCLUSIONS : Our epigenetic aging signature provides a simple biomarker to estimate the state of aging in blood.
CONCLUSIONS : Our experience confirmed that N-of-1 trials may help make personalized evidence-based decisions in complex older patients , with special feasibility considerations.
CONCLUSIONS : Our findings are consistent with the hypothesis that fibromyalgia is related to a general dysregulation of the central nervous system.
CONCLUSIONS : Our findings are similar to previous studies showing few patients have conversations with providers about the cost of glaucoma medications.
CONCLUSIONS : Our findings confirm a higher variability of BPS over time in the MCI group than in AD patients.
CONCLUSIONS : Our findings confirm that telomere length in older-age adults is shorter than in younger subjects.
CONCLUSIONS : Our findings define the QKI isoforms as Ago2-interacting proteins.
CONCLUSIONS : Our findings demonstrated sex differences in ACS incidence and risk factors , but not in ACS-related mortality in Chinese patients withT2DM.
CONCLUSIONS : Our findings did not consistently confirm our hypothesis that psychosocial stress is associated with shorter TL in older adults.
Conclusions : Our findings do not seem to support the use of MEWS to predict the in-hospital mortality risk of sepsis in MWs.
CONCLUSIONS : Our findings do not support an association between SNPs associated with circulating 25 ( OH ) D and risk of colorectal cancer.
CONCLUSIONS : Our findings do not support the hypothesis that subjective loneliness is associated with increased morbidity or mortality from age @number@ to @number@
CONCLUSIONS : Our findings establish that Klotho performs as a tumor suppressor and modulator of IGF-1R signaling in DLBCL.
CONCLUSIONS : Our findings have clarified existing use and understanding regarding the concept of older adults ' persistent pain self-management.
Conclusions : Our findings have important implications for development of interventions and policies to bolster breast cancer screening among Chinese women.
CONCLUSIONS : Our findings highlight the critical role of CCRK in a self-reinforcing circuitry that regulates HBV-associated hepatocarcinogenesis.
CONCLUSIONS : Our findings implicate a role for homocysteine in the development of a generalized small-vessel disease in which both brain and kidney are affected.
CONCLUSIONS : Our findings indicated that health risk awareness may pose a significant preventive effect on trochanteric hip fractures.
CONCLUSIONS : Our findings indicate significant VBM brain changes in both young and middle-aged individuals with StD.
CONCLUSIONS : Our findings offer a relatively comprehensive perspective of T2D-related cognitive deficits , comorbidities , and modulating influences.
CONCLUSIONS : Our findings provide support for early-life developmental programming by linking newborns ' perinatal complications to accelerated aging at midlife.
CONCLUSIONS : Our findings reconcile reports of early changes in immediate recall with greater reliance on delayed recall performance in clinical settings.
CONCLUSIONS : Our findings reveal for the first time the role of the mitochondrial intermediate peptidase in human disease.
CONCLUSIONS : our findings reveal that miRNAs both positively and negatively influence life span.
CONCLUSIONS : Our findings show a high prevalence of MCI in the elderly urban population in the Hebei province.
CONCLUSIONS : Our findings show that a FCR dietary regime is effective in improving mood states and nutritional status among ageing men.
CONCLUSIONS : Our findings show that diabetes causes a major burden in the EMR , which is increasing.
CONCLUSIONS : Our findings stressed that different aspects of SEP were not interchangeable in relation to immigrant health.
CONCLUSIONS : Our findings suggest an age-related deficiency in neural function and resource allocation during inductive reasoning.
CONCLUSIONS : Our findings suggest an independent association between moderate to severe postoperative thrombocytopenia and postoperative stroke , and timing of stroke after CABG surgery.
CONCLUSIONS : Our findings suggest a reduced primacy effect in aMCI already during learning , contrasting previous findings in normal cognitive aging.
CONCLUSIONS : Our findings suggest a small beneficial effect of progestin intrauterine devices and progestin-only oral contraceptives on recovery from pelvic girdle pain.
CONCLUSIONS : Our findings suggested that dual-task costs in gait increase as the complexity of the cognitive task increases.
CONCLUSIONS : Our findings suggested that frailty and poor self-rated general health were independent predictors of depressive symptoms in community-dwelling elderly people.
CONCLUSIONS : Our findings suggest that elevated CRP levels are independently associated with the presence of depressive symptoms in elderly Korean men.
CONCLUSIONS : Our findings suggest that exacerbates endothelial dysfunction during oxidative stress.
CONCLUSIONS : Our findings suggest that heredity may play a significant role in the determination of several markers of inflammation in African ancestry individuals.
CONCLUSIONS : Our findings suggest that high selenium may play a harmful role in the development of hypertension.
CONCLUSIONS : Our findings suggest that increased perfusion of the OFC and the ACC is associated with a poor antidepressant response.
CONCLUSIONS : Our findings suggest that laparoscopic sacropexy is a valid option in elderly women presenting with genital prolapse.
CONCLUSIONS : Our findings suggest that left ventricular longitudinal relaxation velocity declines as a part of healthy aging and is largely prognostically benign.
CONCLUSIONS : Our findings suggest that loneliness and depression may have negative impacts on global and specific domains of cognitive function in non-demented elderly males.
CONCLUSIONS : Our findings suggest that LTL is not consistently associated with HPA axis activity during a standardized psychosocial stress test in elderly adults.
CONCLUSIONS : Our findings suggest that Mediterranean dietary pattern has a favorable role in the prevention of sarcopenia.
CONCLUSIONS : Our findings suggest that poor balance control is an important factor that contributes to longer STW and turning durations on the TUG test.
CONCLUSIONS : Our findings suggest that pre-frailty , which is potentially reversible , is independently associated with a higher risk of older adults developing CVD.
CONCLUSIONS : Our findings suggest that sensitive skin is closely associated with the dysfunction of muscle contraction and metabolic homeostasis.
CONCLUSIONS : Our findings suggest that sIL-2R is associated with current cognitive function in men.
CONCLUSIONS : Our findings suggest that some CHD loci previously identified in individuals of European ancestry may be relevant to incident CHD in African Americans.
CONCLUSIONS : Our findings suggest that specific memory activities are beneficial to elderly people living in a retirement home context.
CONCLUSIONS : Our findings suggest that streamlining financial assistance programs may improve Medicare beneficiaries ' access to benefits.
CONCLUSIONS : Our findings suggest that the impact of stress and hypertension is mediated by individual coping strategies.
CONCLUSIONS : Our findings suggest that the profile of cognitive deficits associated with MTLE is already established as children with temporal lobe epilepsy enter adulthood.
CONCLUSIONS : Our findings suggest that tooth loss is associated with cognitive function.
CONCLUSIONS : Our findings support previous evidence that dentition is the main determinant of the morphology of the mandible.
CONCLUSIONS : Our findings underscore the importance of considering cell composition variability in epigenetic studies based on whole blood and other heterogeneous tissue sources.
CONCLUSIONS : Our genome-wide search of Caribbean Hispanic individuals identified several novel genetic variants associated with LOAD and replicated these associations in a white cohort.
CONCLUSIONS : Our health economic evaluation shows micafungin bridging in aSCT patients did not result in excess cost.
CONCLUSIONS : Our HIV population had a lower rate of PJI compared to infection rates in prior literature.
CONCLUSIONS : Our hypotheses were partially confirmed , though associations were inconsistent across behaviours and absent for alcohol consumption.
CONCLUSIONS : Our main finding is evidence of a strong interaction by race / ethnicity in the association between LTL and age-at-menopause.
CONCLUSIONS : Our mortality prediction models using administrative data showed good discriminatory power in CAP patients.
CONCLUSIONS : Our new sarcopenia index using simple parameters would be useful for diagnosing sarcopenia in CVD patients.
CONCLUSIONS : Our observations indicate that age and duration of dialysis before transplantation were independent determinants of sarcopenia and pre-sarcopenia in these kidney transplant recipients.
CONCLUSIONS : Our observations suggest that cord blood ECFC have a lower pro-inflammatory and pro-thrombotic profile than adult ECFC.
CONCLUSIONS : Our pilot study suggests that CR is well tolerated by most older outpatients with schizophrenia.
CONCLUSIONS : Our preliminary findings show an age-related decline in demand-related , passive early sensory processing.
CONCLUSIONS : Our preliminary findings suggest that the incidence of AC is remarkably increased in carriers of these genetic mutations.
CONCLUSIONS : Our preliminary results demonstrate that the risk of endometrioma recurrence decreases with age.
CONCLUSIONS : Our report discloses different sex- and age-related brain metabolism.
CONCLUSIONS : Our result indicates that acute spatial neglect has a negative impact on regaining of functional mobility in the community.
CONCLUSIONS : Our results add to growing evidence that PTSD may be associated with more rapid cellular aging as measured by telomere erosion.
CONCLUSIONS : Our results are consistent with the increasing evidence that cognitive functions share genetic factors with schizophrenia and bipolar disorder.
CONCLUSIONS : Our results confirm previous findings of a weak relationship between medically based measures of health and life satisfaction.
CONCLUSIONS : Our results confirm that ageing is a major factor contributing to declines in both kidney and cardiac diastolic function in a healthy population.
CONCLUSIONS : Our results confirm the association between AWP and CF.
CONCLUSIONS : Our results contribute to characterizing the expression of white matter structural alterations in adult Down syndrome.
CONCLUSIONS : Our results demonstrate that at least in worms , specific genetic pathways that modify the development of sarcopenia can be identified.
CONCLUSIONS : Our results demonstrate the involvement of the tri-allelic 5-HTTLPR genotype in explaining clinically relevant inter-individual differences in pain perception and regulation.
CONCLUSIONS : Our results emphasize the importance of physical function and body composition in estimating TDEE.
CONCLUSIONS : Our results for each model collectively showed that tele-homecare in Japan is cost-saving to some extent.
CONCLUSIONS : Our results highlight ability of ELF-EMF to modulate inflammation mediators and keratinocyte proliferation / migration , playing an important role in wound repair.
CONCLUSIONS : Our results highlight a progressive nonlinear decline of PA involvement in both groups.
Conclusions : Our results highlight the opportunity to intervene at both the provider and the site levels to improve testosterone prescribing.
CONCLUSIONS : Our results identified genetic risk factors for signs of skin aging ( pigmentation , wrinkles or laxity ) in Han Chinese.
CONCLUSIONS : Our results indicate an undertreatment of osteoporosis in persons with dementia , although osteoporotic fractures are common among these patients.
CONCLUSIONS : Our results indicated that age and gender have only minor effects on the immune modulation abilities of probiotics.
CONCLUSIONS : Our results indicate that AQP-4 genetic variations and haplotypes might contribute to the risk factors for LA.
CONCLUSIONS : Our results indicate that elderly men have poorer orthostatic tolerance during protracted postural stress than women of the same age.
CONCLUSIONS : Our results indicate that functional characterization of human genes is biased against young , tissue-specific genes that are mostly medically relevant.
CONCLUSIONS : Our results indicate that in the context of other risk factors , sexual desire variables at baseline were associated with incident ED.
CONCLUSIONS : Our results indicate that longer habitual sleep duration is associated with lower BMI and age- and sex-specific favorable dietary behaviors.
CONCLUSIONS : Our results indicate that LRRK2 confers cellular protection during oxidative stress depending on mitochondrial function and endocytosis.
CONCLUSIONS : Our results indicate that the measurement of glycated albumin may serve as a useful screening test for diabetes in a general Japanese population.
CONCLUSIONS : Our results provide novel evidence for gender-based modulation of cortisol stress reactivity based on sexual orientation that goes beyond well-established between-sex differences.
CONCLUSIONS : Our results provide reference data on body composition in Swedish populations.
CONCLUSIONS : Our results provide the first in vivo demonstration that TPL2 ablation attenuates obesity-associated metabolic dysfunction.
CONCLUSIONS : Our results revealed significant off-label medication use in both FTD and AD.
CONCLUSIONS : Our results show a dynamic relationship between rs17070145 polymorphism and increasing age on neuronal activity in the hippocampal region.
CONCLUSIONS : Our results showed that the distinction of continued versus discontinued seizures was critical for determining long-term cognitive outcome in childhood-onset epilepsy.
CONCLUSIONS : Our results show high patient satisfaction with ablative fractional skin resurfacing , also regarding improved self-esteem and self-satisfaction despite high pre-treatment expectations.
CONCLUSIONS : Our results show that cerebellar GMv and WMv are differently associated with manual motor performance.
CONCLUSIONS : Our results show that CKD appears to be associated with DR and VTDR in a Korean diabetic population.
CONCLUSIONS : Our results show that resistance training at high external load decreases the resting levels of eHsp70 in older females.
CONCLUSIONS : Our results show that there may be differences between males and females in terms of immune senescence.
CONCLUSIONS : Our results suggest bioenergetic impairment related to mitochondrial function may be progressive in multi-episode bipolar subjects as they age.
CONCLUSIONS : Our results suggest that accelerometer data may be used to predict falls in an unsupervised setting.
CONCLUSIONS : Our results suggest that acquisition of HIV and viral load are primarily responsible for the association between HIV-positive status and shorter LTL.
CONCLUSIONS : Our results suggest that adherence to the MeDi is associated with better cognitive performance and lower dementia rates in Greek elders.
CONCLUSIONS : Our results suggest that age-related decreases in somatosensitivity to electrical stimuli are not due to cutaneous physiological changes.
CONCLUSIONS : Our results suggest that Confusion Assessment Method for the ICU-7 is a valid and reliable delirium severity measure among ICU patients.
CONCLUSIONS : Our results suggest that delayed age at puberty may be associated with negative prodromal symptoms of schizophrenia in males.
CONCLUSIONS : Our results suggest that E-AP-SM2001 has adequate antiaging , antiwrinkle , and whitening benefits and skin moisturizing effect.
CONCLUSIONS : Our results suggest that elevated levels of endogenous bufadienolide CTS represent a potential target for immunoneutralization in patients with preeclampsia.
CONCLUSIONS : Our results suggest that gender-specific needs must be considered in order to motivate older adults to participate in preventive services.
CONCLUSIONS : Our results suggest that in non-pathological aging , hippocampal neural activity does not decrease with age but is rather related to cognitive competence.
CONCLUSIONS : Our results suggest that low serum 25 ( OH ) D is not associated with self-reported symptoms / diagnosis of depression and anxiety.
CONCLUSIONS : Our results suggest that persons with dementia who affirmatively respond to pain questions are at higher risk for developing negative psychosocial states.
CONCLUSIONS : Our results suggest that serum exosomal GGT activity could be a useful biomarker for PC.
CONCLUSIONS : Our results suggest that the functional coupling between SI and SII is influenced by the cortical disinhibition due to normal aging.
CONCLUSIONS : Our results suggest that vitamin D insufficiency is common among Brazilian community-dwelling elderly.
CONCLUSIONS : Our results support a genetic clinical view that compound heterozygous mutations with potential residual protein function are associated with a relatively mild phenotype.
CONCLUSIONS : Our results support the ability of a healthy diet with adequate dairy intake to promote bone health in aging women.
CONCLUSIONS : Our studies indicate that APE1 is a biomarker for predicting prognosis and therapeutic efficacy in NSCLC.
CONCLUSIONS : Our studies provide important new data suggesting possible beneficial effects of the tested drugs on calcium flux regulated pathways in neuronal cell death.
CONCLUSIONS : Our study confirmed a strong predictive ability of most of the proposed frailty indices for 12-month mortality after TAVI.
CONCLUSIONS : Our study confirmed the negative relationship of bipolar depression with social functioning.
CONCLUSIONS : Our study confirms the association between patient survival and tumor stage , hormone receptor and HER2 status.
CONCLUSIONS : Our study covering @number@ years showed relatively stable findings for socioeconomic differences in health care use among older adults in Sweden.
CONCLUSIONS : Our study demonstrated that LRCP is safe and reproducible and represents a minimally invasive option for patients with infiltrative bladder cancer.
CONCLUSIONS : Our study demonstrates increased somatic transfer of mtDNA in colorectal tumors.
CONCLUSIONS : Our study demonstrates that Arg-I promotes endothelial senescence and inflammatory responses through eNOS-uncoupling unrelated to activation of the S6K1 pathway.
CONCLUSIONS : Our study design deemphasized immediate deaths but highlighted long-term sequelae of exposure to viral hepatitis and alcohol.
CONCLUSIONS : Our study found disparities in trends of tooth loss across demographic / socioeconomic strata.
CONCLUSIONS : Our study identified several CSF small-molecule metabolites that discriminated especially well between clinically diagnosed AD and control groups.
CONCLUSIONS : Our study indicates that both CagA + HP infection and CAG go along with accelerated epigenetic ageing.
CONCLUSIONS : Our study in middle-aged and elderly persons suggests that fragmentation of the 24-hr activity rhythm is associated with depression and anxiety.
CONCLUSIONS : Our study is the first to investigate the global methylation effects in humans resulting from heterozygous mutations in SMCHD1.
CONCLUSIONS : Our study lends support to the previously contested notion that assimilation is associated with an increased diabetes risk in Mexican immigrants.
CONCLUSIONS : Our study provide evidences that hAMSC microenvironment secretes soluble factors able to inhibit prostate cancer cells growth.
CONCLUSIONS : Our study provides a global resource on the metabolic adaptations and its transcriptional regulation during aging of human skin.
CONCLUSIONS : Our study provides reference values of pediatric RNFL thickness measured with SD-OCT.
CONCLUSIONS : Our study provides the normative database for Indians on Spectralis OCT.
CONCLUSIONS : Our study revealed comparatively more adipose tissue in human SBRN with advancing age.
CONCLUSIONS : Our study showed that associative learning is impaired in both SCZ and BD , being potentially not affected by medication.
CONCLUSIONS : Our study showed that in a sample of elderly community dwellers , Met S was associated with poor memory and executive performance.
CONCLUSIONS : Our study shows encouraging results and demonstrates that minimally or less invasive osteosynthesis technique could lead to good outcome in these patients.
CONCLUSIONS : Our study shows intrapleural coadministration of tPA / DNase was effective and safe in management of CPEE.
CONCLUSIONS : Our study shows that \ "Gustavo \ " is a promising tool for health education , in schools or in other environments.
CONCLUSIONS : Our study shows that there is a close relationship between unusual sleep postures and SDB-RSs.
CONCLUSIONS : Our study suggests that MS may have little impact on sexual function in middle- to old-aged women.
CONCLUSIONS : Our successful replication and scaling of the PNRP navigation model to DuPage County illustrates a promising approach for future navigator research.
CONCLUSIONS : Our targeted MTM intervention resulted in improvement in anticholinergic medication appropriateness and reduced the use of inappropriate anticholinergic medications in older patients.
CONCLUSIONS : Over a 15-year period ( 1991-2005 ) , increases in non-AIDS-defining cancers were mainly driven by growth and aging of the AIDS population.
CONCLUSIONS : Overall , cardiovascular health was significantly better in the later-born cohort , but several notable exceptions exist.
CONCLUSIONS : Overall , ED geriatric services improved in Quebec from @number@ to 2013 / 14.
CONCLUSIONS : Overall , FAIR had higher estimated relative CBF and lower interindividual variability than PICORE.
CONCLUSIONS : Overall increase trends in PC incidence and lethality were observed.
Conclusions : Overall , older immigrants with greater coping resources seemed to have less family and marital conflict.
CONCLUSIONS : Overall , our results indicated that both Trisomy @number@ and cognitive impairment were associated with distinct patterns of DNA methylation.
CONCLUSIONS : Overall predictors of DC were appropriate but SGA B and C patients and those eating < 50% were missed.
CONCLUSIONS : Overall , results indicate nonlinear longitudinal relations of total cholesterol to cognitive decline.
CONCLUSIONS : Overall , the available evidence favors the implementation of structured intervention programs , although the results are heterogeneous.
CONCLUSIONS : Overall , the commonly obtained measures of sleep contributed little to subjective ratings of prior-night sleep quality.
CONCLUSIONS Overall , the results demonstrated that allicin protects HUVECs from H2O2-induced oxidative stress and aging via the activation of Sirt1.
CONCLUSIONS : Overall , these results indicate impaired WM in age-related disorders with a gradient between MCI and AD.
CONCLUSIONS : Overall , these results suggest a promising role for MSCs in preclinical studies of HIE.
CONCLUSIONS : Overall , these results suggest that subjective measures of sleep do not allow differentiating cognitively impaired older individuals from those with normal cognition.
CONCLUSIONS : Over one in five elderly nursing home residents with dementia used medications with marked anticholinergic activities.
CONCLUSIONS : Overweight across the life course has a cumulative influence on adipokines , inflammatory and possibly endothelial markers.
CONCLUSIONS : Oxidative DNA damage of cardiomyocytes was not correlated positively with age in human beings.
CONCLUSIONS : Oxycodone DETERx was efficacious and generally well tolerated in patients ≥65 years old.
CONCLUSIONS : Oxycodone is frequently initiated for non-cancer pain without first trialing other analgesics.
CONCLUSIONS : P300 recordings are abnormal in DLB and can be useful to distinguish DLB from AD.
CONCLUSIONS : Paediatric heart transplantation patients reported overall similar quality of life as patients with moderate congenital heart disease.
CONCLUSIONS : Pain complaints are common in the older population.
CONCLUSIONS : Pain is an important determinant of neuropsychiatric symptoms , mortality , quality-of-life , and antipsychotic prescriptions.
CONCLUSIONS : Pain , physical activity , and body mass index , potentially modifiable factors , are determinants of transitions.
CONCLUSIONS : Pain self-report in both cognitively intact and impaired community-dwelling persons is associated with a similar multidimensional experience.
CONCLUSIONS : Paradoxical aging changes of AVN electrophysiological characteristics were associated with a different atrioventricular nodal conduction property and the number of RF impulses.
Conclusions : Parasite biomass , endothelial activation , and microvascular dysfunction are associated with severe disease in knowlesi malaria and likely contribute to pathogenesis.
CONCLUSIONS : Parathyroidectomy is a safe and effective procedure to perform in elderly patients.
CONCLUSIONS : Parental longevity is associated inversely with cognitive decline and self-reported diagnosed memory disorders in aging offspring.
CONCLUSIONS : Parotid fat content in healthy adults correlates positively with both age and BMI ; the correlation with age is gender-dependent.
CONCLUSIONS : Participants found inherent value in having visualizations available to proactively engage with their healthcare provider.
CONCLUSIONS : Participants who retired before the age of @number@ declined in cognitive ability over the 6-year study period.
Conclusions : Participants with probable MCI were less active and more sedentary.
CONCLUSIONS : Participation in leisure-time activities is an important health promoter in aging populations.
CONCLUSIONS : Participation restriction was common in this sample of frail , community-dwelling older people.
CONCLUSIONS : Particularly after 41-50 years of age , level of eyebrow and eyelash whitening may be among a useful age estimation parameter.
CONCLUSIONS : Partnered women commonly resume sexual activity soon after an MI with fear but without directed counseling from their physicians.
CONCLUSIONS : Paternal occupation and legitimacy status were strong predictors of offspring longevity in this one-century historical cohort born during World War One.
CONCLUSIONS : Patient needs and expectations for support are shaped both before and after TKA surgery.
CONCLUSIONS : Patient perception towards autonomous monitoring devices was positive , lending credence to zero-effort technology as a viable and promising approach.
CONCLUSIONS : Patient selection is crucial when considering neurosurgery in the octogenarian population.
Conclusions : Patients undergoing rhytidectomy < 50 years old begin less invasive facial rejuvenation treatments at an even earlier age.
CONCLUSIONS : Patients with a diagnosis of polyneuropathy experience increased mortality , morbidity and socioeconomic consequences.
CONCLUSIONS : Patients with advanced age represent a substantial subgroup of patients requiring renal replacement therapy in the ICU.
Conclusions : Patients with coexisting T2D and osteoporosis should be managed in an optimal way according to scientific evidence.
CONCLUSIONS : Patients with DC show an increase in number and maximal dilation of lymphatic vessels in conjunction with widely spaced collagen bundles.
CONCLUSIONS : Patients with DED have an accelerated corneal endothelial cell loss compared with that reported in the literature for normal aging.
CONCLUSIONS : Patients with diabetes were younger at dementia diagnosis and obtained less dementia medication for Alzheimer disease , suggesting less optimal dementia treatment.
CONCLUSIONS : Patients with DM had mean FRAX scores lower than control subjects , despite the higher number of previous fractures.
CONCLUSIONS : Patients with hyperthyroidism-related AF are at high risk of stroke ( @percent@ per year ) .
CONCLUSIONS : Patients with knee pain post TKA need systematic assessment to identify the causes.
CONCLUSIONS : Patients with lower eGFRs have differentially higher hemorrhage risk at INR ≥ @number@
CONCLUSIONS : Patients with osteoporosis are prone to cognitive impairments especially declarative memory deficits.
CONCLUSIONS : Patients with PD exhibited significant differences in all variables of interest compared to the controls.
CONCLUSIONS : Patients with pediatric ALL experience unhealthy weight gain early in treatment , and increases in weight are maintained beyond treatment completion.
CONCLUSIONS : Patients with PreCI have an increased incidence of POCD and cognitive decline.
CONCLUSIONS : Patients with remote cholecystectomy have larger common duct diameters than those with no or interval cholecystectomy.
CONCLUSION ( S ) : Patients with two types of male factor infertility display an increased abnormal methylation of CREM compared with control subjects.
CONCLUSIONS : Patients with XP often exhibit ocular changes.
CONCLUSIONS : Patterns of loss of lung health are associated with specific cardiovascular phenotypes in middle age.
CONCLUSIONS : PCA is an excellent chemometric algorithm that may be used to characterize MGD and age-related changes in human meibum.
CONCLUSIONS : PCIs have the capacity to impair the IgE-binding capacity of airborne HDM allergens in a simulated environmental condition.
CONCLUSIONS : PC-MRI age-related reference ranges of diastolic parameters are provided.
Conclusions : PD and healthy speakers varied their acoustic output on the basis of word frequency and neighborhood density.
Conclusions : PD in spoken language reflects the cognitive decline in people with aMCI , but the effect is relatively mild.
CONCLUSION : Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia.
CONCLUSION : Specific STOPP recommendations provided to hospital physicians doubled the reduction of PIMs at discharge in frail older inpatients.
CONCLUSION : Spectral-domain optical coherence tomography confirmed the presence of the pocket in all ages.
CONCLUSION : Speech audiometric assessment of IM is of high relevance with regard to everyday communication situations.
CONCLUSIONS : People aged over @number@ years with long-term disability have significant and increasing health and participation problems.
CONCLUSIONS : People aging with HIV display heterogeneous health conditions.
CONCLUSIONS : People aging with long-term physical disabilities experience unique challenges that affect their risk of falls.
CONCLUSIONS : People who provide care to others appeared to have stronger motivation to complete the workshops with greater benefits.
CONCLUSIONS : People with mobility limitations playing adapted sports and people without limitations have a similar quality of life.
CONCLUSIONS : People with vision loss due to three different age-related eye diseases had lower cognitive scores.
CONCLUSIONS : Perceived psychological well-being , metacognitive efficiency and depression seem to be affected by sociocultural context.
CONCLUSIONS : @percent@ of all patients harbor at least one deleterious variant in established risk genes.
CONCLUSIONS : Perceptions of elderly people by the seniors are different , complex and multidimensional.
CONCLUSIONS : Peripapillary choroidal thickness varies with race and age , as individuals of AD have a thicker peripapillary choroid than those of ED.
CONCLUSIONS : peripheral neuropathy , decreased muscle strength and obesity are strongly associated with walking in persons with type @number@ diabetes without manifest mobility limitations.
CONCLUSIONS : Permanent and semi-permanent fillers did not facilitate bacterial growth when flagellated E. coli HVH-U47 was used.
CONCLUSIONS : Persistent high incidence of infantile-onset disease and clinical heterogeneity according to onset age are characteristic features of MG in Japan.
CONCLUSIONS : Persistently high and moderate levels of perceived uselessness are associated with significant increases in mortality risk.
CONCLUSIONS : Persistent sleep disturbance during a year-long period is associated with depression the following year.
CONCLUSIONS : Personal control and social control were both found to be predictors of functional health status.
CONCLUSIONS : Personality characteristics are related to HRQOL.
CONCLUSIONS : Persons in the IBNA study had clinical and neuropsychological features consistent with that of the general population.
CONCLUSIONS : Peruvian infants in this urban setting had lower rates of stunting than expected.
Conclusions : Perventricular device closure of pmVSDs appears safe and effective with symmetric and asymmetric occluders.
CONCLUSIONS : PET had a moderate effect on clinical outcomes.
CONCLUSIONS : PF decreased more rapidly in obese men and women than among those with normal weight.
CONCLUSIONS : PfS was associated with increased odds of SI and SH in adolescents.
CONCLUSIONS : PhA improves quality of arterial ED , without other pharmacological approach , probably by reduced endothelial apoptosis.
CONCLUSIONS : Pharmacological enhancement of muscle perfusion and amino acid availability during hyperinsulinemia improves the muscle protein anabolic effect of insulin in older adults.
CONCLUSIONS : Physical activity and sedentary behaviour have contrasting associations with markers of low grade inflammation over @number@ years of follow-up.
CONCLUSIONS : Physical activity is associated with significantly lower odds of physical and functional limitations in obese older adults regardless of how obesity is classified.
CONCLUSIONS : Physical activity regulates telomere-stabilizing proteins in mice and in humans and thereby protects from stress-induced vascular apoptosis.
CONCLUSIONS : Physical frailty , parkinsonian signs score and global motor score are related constructs that capture different aspects of motor function.
CONCLUSIONS : Physical function is associated with quality of life in older persons.
CONCLUSIONS : Physical function significantly declined over @number@ years , in particular in the oldest group.
CONCLUSIONS : Physical inactivity is highly prevalent , particularly among Afro -Brazilians.
CONCLUSIONS : Physical pain may be relieved by various means of pain management.
CONCLUSIONS : Physical , psychological and literacy issues pertaining to both patients and providers present barriers to effective communication.
CONCLUSIONS : physical rehabilitation may improve independence for elderly long-term care facility residents , but mean effects are small.
CONCLUSIONS : Physical symptoms are an important component of premenstrual syndromes.
CONCLUSIONS : Physical training , especially resistance training successfully reduces hyperleptinemia even without diet or major weight loss.
CONCLUSIONS : Physician-CHW partnership had a positive impact on patients ' self-management skills and clinical outcomes.
CONCLUSIONS : Physicians will reduce potential harm to patients and increase the value of health care when implementing these recommendations.
CONCLUSIONS : Physiological load and psychological stress were temporarily high , even in young , fit firefighters.
CONCLUSIONS : PiB + individuals with SCD are at greatest risk of cognitive decline.
CONCLUSIONS : Pictograms are not the universal communication system as we formerly thought.
CONCLUSIONS : PIDP is a significant problem among Italian NH residents.
CONCLUSIONS : Pinguecula is far more common than pterygium.
CONCLUSION : Spirometry can be undertaken in primary care offices with acceptable levels of technical expertise.
CONCLUSIONS : PIs triggered premature senescence in endothelial cells by a mechanism involving prelamin A accumulation.
CONCLUSIONS : Plantarflexor muscle-tendon properties were associated with mobility in older adults independent of lower extremity lean mass , leg extension strength , or power.
CONCLUSIONS : PLA provides noninferior efficacy compared with HA @number@ months after being used to treat moderate to severe nasolabial folds.
CONCLUSIONS : Plasma and dietary DHA appear to protect against dementia.
CONCLUSIONS : Plasma esRAGE is correlated with higher IL-6 and lower IL-1RA.
CONCLUSIONS : Plasma FABP4 was positively associated with incident diabetes in older adults , and such association was statistically significant in lean men only.
CONCLUSIONS : Plasma klotho and 25 ( OH ) D both positively related to lower-extremity physical performance.
CONCLUSIONS : Platelet TXNIP content increases with aging , varies inversely with responsiveness to NO , and diminishes rapidly following treatment with ramipril.
CONCLUSIONS : PLE is a rare disease.
CONCLUSIONS : PM2.5 seven day moving averages are associated with higher sICAM-1 and sVCAM-1 levels.
CONCLUSIONS : PM plays an important role in self-report of successful medication management among older adults.
Conclusions point towards a differentiated use and intensity of health services depending on age.
CONCLUSIONS : Polarization-enhanced multispectral wide-field reflectance imaging method is a suitable technique for noninvasive in vivo assessment of dermal structures.
CONCLUSIONS : Policy and practice changes are needed to reduce the risk that youths in foster care will become homeless after aging out.
CONCLUSIONS : Polishing zirconia increased surface roughness and led to surface phase changes , but wear to the antagonist was not affected.
CONCLUSIONS : Polymorphisms of MMP7 and MMP20 genes may be surrogate markers to predict long-term outcomes after kidney transplantation.
CONCLUSIONS : Polypharmacy and PIM use were common but were not associated with chemotherapy-related toxicity or hospitalization in older adults with cancer.
CONCLUSIONS PON1 polymorphism might be one of the genetic factors of longevity in the Bama Zhuang population.
CONCLUSION : Spontaneous activity in the precuneus could predict individual differences in verbal fluency processing.
CONCLUSIONS : Poor diet quality , as assessed by the DST , is associated with lower HRQOL in adults ≥ @number@ years of age.
Conclusions : Poorer function , not cognition or BPSD , was associated with higher Medicare expenditures.
CONCLUSIONS : Poor patient recognition of eye disease among the Korean elderly highlights the seriousness of this potential public health problem in our aging society.
CONCLUSIONS : Poor sleep quality is highly prevalent among elderly Chinese residents in urban Shanghai.
CONCLUSIONS : Population-based data support a possible birth cohort phenomenon in IBS.
CONCLUSIONS : Positive and sometimes sustained improvement in balance confidence can be achieved by various interventions among community-dwelling elderly persons.
CONCLUSIONS : Positive life orientation declines during old age , especially from age @number@ to @number@ years.
CONCLUSIONS : Posterior brain arteries differ pathologically from anterior brain arteries in the degree of wall thickening , elastin loss , and concentric intimal thickening.
CONCLUSIONS : Postmenopausal vulvovaginal symptoms did not correlate with vaginal inflammatory marker.
CONCLUSIONS : Postmenopausal women experience the most severe symptoms.
CONCLUSIONS : Postmenopausal women not taking HT had a good overall vocal quality.
CONCLUSIONS : Postural instability increases with the addition of a secondary task in older persons , which may put them at greater risk of falls.
CONCLUSIONS : Power training increased neuromuscular activation during isometric contractions and level gait in old adults.
CONCLUSIONS : PPI co-medication in LDASA users at risk of UGI adverse effects is generally cost effective.
CONCLUSIONS : PP may be associated with diminished ovarian reserve.
CONCLUSIONS : Practice effects are prominent particularly in the early phase of high-frequency repetitive cognitive testing of healthy well-performing subjects.
CONCLUSIONS : Practices or interventions that support or improve internal resources could potentially improve caregiver well-being.
CONCLUSIONS : Pre-admission clinical frailty independently predicts adverse discharge destination in geriatric trauma patients.
CONCLUSIONS : Prediction of treadmill walking capacity from the WIQ score should account for age.
CONCLUSIONS : predictive models can be constructed that use linked , routine health and social care data for case finding in social care settings.
CONCLUSIONS : Predictors of NHP may differ in old age groups.
CONCLUSIONS : Pre-existing hearing loss can increase the risk of hearing impairment due to occupational noise exposure.
CONCLUSIONS : Preferences change in the process of ageing and growing health problems.
CONCLUSIONS : Prefrontal brain activity levels while performing a cognitively demanding walking condition predicted falls in high-functioning seniors.
CONCLUSIONS : Pregnancies complicated by GDM have decreased fetal pref-1 concentrations compared to normal pregnancies.
CONCLUSIONS : Premature aging appears to occur in some systems after SCI.
CONCLUSIONS : Premature introduction of non-breastmilk items is commonly practiced in feeding Guatemalan infants.
CONCLUSIONS : Premature skin aging is common in the subtropics , more severe in men and the fair-skinned.
CONCLUSIONS : Pre-morbid IQ was found to be significantly associated with the development of mental disorder.
CONCLUSIONS : Prenatal DHA supplementation of primigravid women may result in increased birth size in a population where dietary DHA intakes are very low.
Conclusions : Preoperative DCD , GCD , and SMR are parameters correlated with the filtration surgery outcome , with DCD presenting the strongest correlation.
CONCLUSIONS : Preoperatively known factors alone can predict the relative chances of deferring extubation after surgery for CHD.
CONCLUSIONS : Preoperative sestamibi scintigraphy confirmed its importance in improving the information obtained through different diagnostic investigations.
CONCLUSIONS : Prescribers should be alert to the possibility of potentially harmful interactions between NSAIDs and commonly prescribed drugs in the elderly.
CONCLUSIONS : Prevalence figures for depressive symptoms among elderly in rural Bangladesh are high.
CONCLUSIONS : Prevalence of AMD in Nepalese presenting to Kathmandu Medical College Teaching Hospital was @percent@ with female preponderance in ratio of @number@.5 : 1.
CONCLUSIONS : : Prevalent depressive symptoms were significantly lower among elderly Japanese American men who were most culturally Japanese , compared to more westernized men.
CONCLUSIONS : Prevalent hemodialysis patients demonstrate significant cognitive decline , particularly within tests of executive function.
CONCLUSIONS : Preventing deterioration in vision is the best means of ensuring well-being is not negatively affected by changes to sight.
CONCLUSIONS : Previous findings of null or protective associations between hypertension and cognition likely reflect the study of persons with short duration since hypertension initiation.
CONCLUSIONS : Previous mechanized methods of assessing CCC strength used excised anterior capsules or partially phacoemulsified crystalline lenses , yielding lower tension strength values.
CONCLUSIONS : Primary HPV DNA screening with cytology triage is more sensitive than conventional screening.
CONCLUSIONS : Primary pharmacologic prevention and assessment of osteoporosis or risk of fracture are unfrequent in our health district..
CONCLUSIONS : Primary pleural DLBCL is a rare disease.
CONCLUSIONS : Prior nonadherence to APDs might influence initiation of APD modification.
CONCLUSIONS : PR is equally effective in elderly and younger patients with COPD , with efficacy influenced by body mass index and anxiety.
CONCLUSIONS : Procalcitonin levels were not influenced by aging , and procalcitonin kinetics might help to identify treatment failure.
CONCLUSIONS : Processed tomatoes may have a higher content of health-benefiting compounds than fresh ones.
CONCLUSIONS : Progression of WMH volume in dementia-free older persons is associated with levels of circulating plasma Aβ.
CONCLUSIONS : Progression to permanent AF is a slow process.
CONCLUSIONS : Prolift repair has a high anatomical success rate.
CONCLUSIONS : Prolonged contact of mineralized dentin with CSMs has an adverse effect on the integrity of the dentin collagen matrix.
CONCLUSIONS : Proper weight management during aging is crucial in preventing functional limitations in middle-aged and older adults.
CONCLUSIONS : Propofol and aging act in synergy to depress the activity of the cardiovascular component of the autonomic nervous system.
CONCLUSIONS : Prospective randomized controlled trial to better evaluate PF risk factors is needed.
CONCLUSIONS : Prostate cancer mortality in the Taiwanese general population is increasing.
CONCLUSIONS : Protein supplementation might improve reaction time performance in pre-frail and frail elderly , but did not improve other cognitive functions.
CONCLUSIONS : Proteinuria , a dominating manifestation in elderly patients subjected to kidney biopsy was most commonly related to glomerulopathies.
CONCLUSIONS : Proven interventions , most notably pre-exposure prophylaxis , PrEP , have been limited in rollout and impact.
CONCLUSIONS : Providing instrumental social support to others confer benefits to the giver and prolong life expectancy among the elderly with low educational levels.
CONCLUSIONS : Providing numeric AE-likelihood information ( compared with nonnumeric ) is likely to increase risk comprehension across numeracy and age levels.
CONCLUSIONS : Psoriasis in patients older than @number@ years represents a significant proportion of cases and its prevalence is expected to increase.
CONCLUSIONS : PS remains a key predictor of chemotherapy-related toxicity in elderly patients.
CONCLUSIONS : Psychosis in Alzheimer's disease has been associated with a number of adverse clinical outcomes.
CONCLUSIONS : Psychosocial and clinical factors were associated with risk of hospitalization independently of the VACS Index score.
Conclusions Psychosocial working conditions predicted decline in SRH in this 5-year follow-up study.
CONCLUSIONS : Psychotropic polypharmacy , antipsychotic , and anticonvulsant use increased with each year of follow-up.
CONCLUSIONS : PTSD in the elderly must be considered within the context of normal aging.
CONCLUSIONS : PTT low blood supply causes a dysfunction resulting in an abnormal loading of the foot's medial structures.
CONCLUSIONS : Public health practice should monitor and target inequalities in functional performance , as well as risk of disease and death.
CONCLUSIONS : Published rates of AD completion vary widely among patients presenting to U.S. EDs.
CONCLUSIONS : Pulmonary toxicity is a common long-term complication of exposure to certain anticancer therapies in childhood and can vary from subclinical to life threatening.
CONCLUSIONS : Pulp response time increases when people get older while pain intensity decreases.
CONCLUSIONS : Purpose in life may affect risk for cerebral infarcts , specifically macroscopic lacunar infarcts.
CONCLUSION : SQJN can regulate the metabolism of fluid through recovering the normal physiologic function of the detrusor of bladder.
CONCLUSIONS : Quality cancer care depends on the integration of quality palliative care.
CONCLUSIONS : Quality of care delivered to elderly patients undergoing major surgery at our institution was generally poor and independent of patient characteristics.
CONCLUSIONS : R6 treatment was shown to improve the lipid profile indicating a reduction of cardiovascular risk.
CONCLUSIONS : Racecadotril is more effective than loperamide-probably due to drug interaction with loperamide-and it is not related to pharmacogenetic susceptibility.
CONCLUSIONS : Race / ethnic group and insurance type are partially independent factors affecting survival expectations for patients diagnosed with CRC.
CONCLUSIONS : Racial / ethnic variations were found in the relationship between self-perception of mental health and DSM-IV psychiatric disorders.
CONCLUSIONS : Racial minority groups have a greater preference for community services than third generation Australians.
CONCLUSIONS : RAC mortality ( especially post admission ) is high.
CONCLUSIONS : RA continues to cause modest global disability , with severe consequences in the individuals affected.
CONCLUSIONS : Radiographic trapeziometacarpal arthrosis is an expected part of human aging.
CONCLUSIONS : RAGE ligands or anti-sRAGE autoantibodies did not interfere with sRAGE quantification.
CONCLUSIONS : Raman spectroscopy shows promise for evaluating the compositional contributors of bone quality in ex vivo specimens , although further validation is still needed.
CONCLUSIONS : Rates of severe pre-eclampsia have been increasing in the United States and age-period-cohort effects all contribute to these trends.
CONCLUSIONS : RBCs displayed significant changes in all measured indices of oxidative and inflammatory stress during a storage period of @number@ days except for AT.
CONCLUSIONS : RC-RBCs and RTH-RBCs show only small differences of classical in vitro parameters and no relevant differences in antioxidative metabolism and oxidative haemoglobin modification.
CONCLUSIONS : Reanalysis of previously published experimental data is cost-effective approach for extraction of additional insignts into the functioning of biological systems.
CONCLUSIONS : Recalled weight comes close to the assessed population mean , but at the individual level there is a large variation.
CONCLUSIONS : Recent socioeconomic changes appear to contribute to increased weight , BMI , and stature at younger ages in the Mt Ok at Telefomin.
CONCLUSIONS : Recent stressful late-life events have a greater impact on the cognitive status of individuals with an ϵ4 allele.
CONCLUSIONS : Recommendations for policy change need to be focused at the societal level.
CONCLUSIONS : Recurrent pneumonia constitutes a considerable proportion of the pneumonia burden in Japan.
CONCLUSIONS : Reduced GC activity is associated with an increased prevalence of ThAbs positivity in older ambulatory subjects.
CONCLUSIONS : Reducing sitting time is feasible , and the intervention shows preliminary evidence of effectiveness among older adults with overweight and obesity.
CONCLUSIONS : Reducing sPLA2-IIA mass is unlikely to be a useful therapeutic goal for preventing cardiovascular events.
CONCLUSIONS : Reductions in daily PA predicted acute decline in attention / executive function in HF , but not of memory or language.
CONCLUSIONS : Reference intervals of serum lipid parameters for healthy Indian children ( 6-17 years ) are presented.
CONCLUSIONS : Reference ranges for ROTEM assays were determined for all paediatric age groups.
CONCLUSIONS : Refractive testing resulted in an improvement in BCVA over PVA in the majority of patients , over a wide range of ages.
CONCLUSIONS : Regardless of the model , KStrength60° was the best predictor of MGS in rural female older adults.
CONCLUSIONS : Regional atrophy is related to impairment in specific cognitive domains in AD.
CONCLUSIONS : Regional infection patterns varied by sex and parasite species , perhaps due to MI-linked environmental and lifestyle changes.
CONCLUSIONS : Regression analysis revealed significant relationships between time of day , ambient daytime high temperature and a humidity for participation in PA.
CONCLUSIONS : Regression for recurrent events is feasible with typical falls ' study data.
CONCLUSIONS : Regular consumption of sugar-sweetened sodas might influence metabolic disease development through accelerated cell aging.
CONCLUSIONS : Regular PA may reduce frailty , especially in individuals at higher risk of disability.
CONCLUSIONS : Regular physical activity was inversely associated with parameters related to advanced cardiovascular aging after adjustment for potentially influencing variables.
CONCLUSIONS : Rehabilitation outcomes for persons with stroke varied across CMS regions.
CONCLUSIONS : relative to African-Americans , White race is a strong predictor of CAC , even in the presence of type @number@ diabetes.
CONCLUSIONS / RELEVANCE : CDR ( as determined by spectral domain OCT ) is abnormal in MS and correlates with visual function.
Conclusions : Remote moderate-to-severe TBI is a risk factor for motor dysfunction-defined as recent falls and impaired posture / gait-among older veterans.
CONCLUSIONS : Renal function impairment is not a rare complication during anti-TB treatment in an elderly population.
CONCLUSIONS : Repeated measurements provide strong evidence for a substantial and sustained decrease in sleep disturbances following retirement.
CONCLUSIONS : Reproductive events were associated with longevity among women.
CONCLUSIONS : Research funding should be invested in the study of the benefits accruing from reducing obesity in the elderly.
CONCLUSIONS : Research in middle-aged and elderly humans suggests that tocotrienols have a potential beneficial anti-ageing action with respect to cognitive impairment and DNA damage.
CONCLUSIONS : Research is needed to examine the causal relationship between these outcomes.
CONCLUSIONS : Research to date suggests multiple classes of medications may impact tDCS effects.
CONCLUSIONS : Resistance training significantly improved global cognitive function , with maintenance of executive and global benefits over @number@ months.
CONCLUSIONS : Respiratory system resistance and dynamic compliance are not modified with ageing.
CONCLUSIONS : Respondents to this survey generally viewed themselves as competent , empathic practitioners.
CONCLUSIONS : Resting state electrophysiology is altered in ADHD , and these electrophysiological impairments persist into adulthood.
CONCLUSIONS : Rest tremor can be a common clinical feature of ET.
CONCLUSIONS : Results are discussed in relation to suggestions for anti-smoking interventions aimed at women in the 18- to 34-year-old age group.
CONCLUSIONS : Results demonstrated that SCH patients failed to follow the \ "normal \ " process of complexity increase as a function of age.
CONCLUSIONS : Results demonstrate sex and age differences in the relation between depressive symptoms and blood pressure.
CONCLUSIONS : Results emphasize that the predictive strength of cognitive variables varies depending on time to conversion to dementia.
CONCLUSIONS : Results emphasize the importance of considering hydration status and blood pressure when interpreting cognitive performance in older adults.
CONCLUSIONS : Results from our sample suggest that low systolic blood pressure is more important for dizziness in older patients than increased cardiovascular risk.
CONCLUSIONS : RESULTS from the current review showed improved driving skills / performance by training , infrastructural assessments , and incorporating mobility assistance tools.
CONCLUSIONS : Results from this study provide greater understanding of user perspectives of HAS.
CONCLUSIONS : Results indicated that objective and subjective QOL domains should be treated separately in clinical practice for this patient population.
CONCLUSIONS : Results indicate that an observation scale of memory function may have value for providing information about the underlying memory impairment.
CONCLUSIONS : Results indicate that home-based elderly women benefit from this easily implemented rocking-chair exercise program.
CONCLUSIONS : Results indicate that preprocessing the acoustic signal is a viable method of improving speech recognition via the telephone.
CONCLUSIONS : RESULTS indicate that there are posterior white matter microstructural changes in individuals with probable MCI.
CONCLUSIONS : Results of this study have implications for developing improved guidance for the public regarding the potential value of cognitively stimulating leisure activities.
CONCLUSIONS : Results of this study partially supported the hypothesis of age-related differences in neural processing of speech at the brain stem level.
CONCLUSIONS : Results of this study suggest that visual signal content affects cross-modal enhancement of speech detection in both young and older adults.
Conclusions : Results of this study suggest there may be a need to better engage older HIV + veterans in depression-related treatment.
CONCLUSIONS : Results point to diminished HPA axis sensitivity as an effect of normal aging , irrespective of gender.
CONCLUSIONS : Results provide needed empirical support for a specific outreach intervention that speeds enrollment and engagement for rural individuals in VA services.
CONCLUSIONS : Results show good internal consistency and construct validity of the SWLS.
CONCLUSIONS : Results show that aging and possibly diverse \ "trauma \ " have an impact on modifying the mechanical behavior of pelvic floor tissues.
CONCLUSIONS : Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults.
CONCLUSIONS : Results suggest a protective effect of gynoid body fat and a deleterious effect of android body fat.
CONCLUSIONS : Results suggest that amygdalar structure is tied to A / D among typically developing youths , independent of age and sex.
CONCLUSIONS : Results suggest that AUTO and MOD endocortical contour methods provide comparable repeatability.
CONCLUSIONS : Results suggest that BD is associated with reduced telomere length.
CONCLUSIONS : Results suggest that effectiveness of TMS for TRD is not differentially modified by age.
CONCLUSIONS : Results suggest the CD-RISC , supplemented by qualitative input , provides a way forward for research on efficacy of intergenerational interventions.
CONCLUSIONS : Results support a broader focus for older adults with multimorbidity that includes mental health needs.
CONCLUSIONS : Results support the applicability of BBS-9 in assessing functional balance among the aged with quite good physical function.
CONCLUSIONS : Results support the mediating role of dispositional hope on the life satisfaction among older adults attending lifelong learning programs.
CONCLUSIONS : Results support the vascular depression hypothesis.
CONCLUSIONS : Retinyl retinoate had characteristic features of new anti-aging agents , and effectively improved facial wrinkle conditions.
CONCLUSIONS : Retirees living abroad report dilemmas regarding healthcare choices , insurance availability , and quality of care.
CONCLUSIONS : Reverse causality due to shrinkage may contribute to the inverse association between a single measurement of height and later CHD in other studies.
CONCLUSIONS : RHR is a trait with a genetic influence in middle-aged and elderly twins free of cardiovascular disease.
CONCLUSIONS : Ride-on car training has positive effects on behavioral changes in mobility and socialization among young children with motor disabilities.
CONCLUSIONS : Right-sided laparoscopic adrenalectomy can be performed safely and effectively via either RLA or TLA.
CONCLUSIONS : Risk factors for late-life depression in Costa Rica are similar to risk factors in high-income countries.
CONCLUSIONS : Risk of malnutrition was common among community-dwelling older people.
CONCLUSIONS : Risky lifestyles and a reluctance to abandon them are responsible for a shorter lifespan among men in Poland.
CONCLUSIONS : RL impairment is common in early AD and MCI , and is occasionally also found in normal elderly subjects.
CONCLUSIONS : Rotational atherectomy is a safe and sufficient technique for the endovascular treatment of heavily calcified coronary artery lesions.
CONCLUSIONS : RPE-derived cell-associated VEGF₁₈₉ facilitates CEC transmigration by Rac1 activation independently of PI-3K signaling and may have importance in the development of neovascular AMD.
CONCLUSIONS : Sacubitril / valsartan can be considered a cost-effective treatment at a daily price of €5.25.
CONCLUSIONS : sAF reflects glycemic and renal status @number@ years before , supporting its value as a marker of metabolic memory in the elderly people.
CONCLUSIONS : Sample composition and exclusionary criteria require consideration when selecting an appropriate normative sample against which to compare older adult test performance.
CONCLUSIONS : Sarcopenia is common in patients with CKD , particularly in the most advanced stages of the disease.
CONCLUSIONS : Sarcopenia was independently associated with cognitive impairment.
CONCLUSIONS : Scandinavian and Bismarckian countries exhibited narrower socioeconomic inequalities in life satisfaction.
CONCLUSIONS : SCD is more prevalent in patients with MCI than in the healthy elderly , but it does not reflect an objective cognitive impairment.
CONCLUSIONS : Schmorl's nodes demonstrated low to moderate uptake on FDG PET / CT images.
CONCLUSIONS : SDD is feasible and safe in selected patients undergoing elective complex PCI using the forearm approach.
CONCLUSIONS : Secondary rhytidectomy is a safe and effective procedure for the aging face.
CONCLUSIONS : Sedentary behaviour continues to be associated with unhealthy diet in young people in mostly cross-sectional studies.
CONCLUSIONS : Seizures after non-complicated cerebral contusions are difficult to treat.
CONCLUSIONS : Self-efficacy beliefs play an important role as predictors of exercise.
CONCLUSIONS : Self-efficacy may play a partial mediating role in the effect on some longer-term functional outcomes in the Home-based Post-Hip Fracture Rehabilitation intervention.
CONCLUSIONS : Self-esteem in diabetic children is mainly affected by their age , level of physical activity and level of family support.
CONCLUSIONS : Self-management abilities and frailty are important for healthy aging among community-dwelling older people in the Netherlands.
CONCLUSIONS : Self-perceived uselessness is associated with higher mortality risks in older adults in China.
CONCLUSIONS : Self-perceived uselessness was associated with a wide range of factors in the REHAB framework.
CONCLUSIONS : Self-rated health is determined by a range of psychological and social factors in addition to disability in older patients with stroke.
CONCLUSIONS : Self-reported sitting time differed by ethnicity , age group , education and body mass index but there was no overall difference by sex.
Conclusions : Self-reported sleep duration , napping , and trouble falling / staying asleep differ by APOE genotype.
CONCLUSIONS : Sepsis survivorship , which has substantial long-term morbidity , is a common and rapidly growing public health problem for older Americans.
CONCLUSIONS : Serial MRI reveals progressive enlargement of LN.
CONCLUSIONS : Serum adiponectin , but not leptin , was negatively and independently associated with Hb.
CONCLUSIONS : Serum BDNF levels may be considered as a marker of response to antidepressant treatment for depression in the elderly.
CONCLUSIONS : Serum IgG levels to common periodontal microbiota are associated with risk for developing incident AD.
CONCLUSIONS : Serum leptin is low in beta-thalassaemia , perhaps due to the toxic effect of iron overload on adipose tissue.
CONCLUSIONS : Serum osteocalcin was negatively associated with free and bioavailable testosterone and positively with luteinizing hormone levels.
CONCLUSIONS : Serum phosphorus level is marginally associated with CVD and more strongly associated with transplant failure and total mortality in long-term KTRs.
CONCLUSIONS : Serum sodium concentration is a cardiovascular risk factor even within the normal reference range.
CONCLUSIONS : Serum TAGE and FF Pent accumulations correlated highly with poor follicular and embryonic development and with a lower likelihood of ongoing pregnancy.
CONCLUSIONS : Serum UA has importance in cardiometabolic examination of youth risk factors.
CONCLUSIONS : Several associations , which differed across the genders , were observed between IGF-1 and depression.
CONCLUSIONS : Several countries have abundant data on HZ , but others , especially in South-East Asia , very few.
CONCLUSIONS : Several factors independently predict ASC after PVI.
CONCLUSIONS : Several gaps exist in the literature.
CONCLUSIONS : Several potential mechanisms may explain poor sleep in urban , community dwelling Blacks.
CONCLUSIONS : Several risk factors are determined to be relevant and amendable.
CONCLUSIONS : Severe hypoglycemia was common among patients with type @number@ diabetes across all levels of glycemic control.
CONCLUSIONS : Severe senile kyphosis is not a contraindication for minimally invasive technique applied to colorectal cancer patients.
CONCLUSIONS : Severe WML significantly increases the risk of developing MCI / dementia over a 7-year period in low educated participants.
CONCLUSIONS : Sex- and age-specific relationships were observed between all-cause mortality rate and specific sleep behaviors among older adults.
CONCLUSIONS : Sex and BMI influenced the rate and degree of the age-related decline in REE.
CONCLUSIONS : Sex hormone deficiency and its duration were significantly associated with the development and progression of soft drusen in women but not in men.
CONCLUSIONS : Sexual dysfunction in aging men is a dynamic disorder whose incidence and remission are predicted by a range of modifiable risk factors.
CONCLUSIONS : SG-ADVISER mtDNA is a fast and functional tool that allows for variant calling and annotation of human mtDNA data coming from NGS experiments.
CONCLUSIONS : SGA , HGS , and food intake were independent predictors of outcomes for malnutrition.
CONCLUSIONS : SGPP2 , a sphingosine-1-phosphate phosphatase , is a novel vitamin D-responsive gene associated with lung function.
CONCLUSIONS : SHARE-FI75 + could help frailty case finding in primary care and provide a focus for personalised community interventions.
CONCLUSIONS : Shortages and geographic variation in the supply of surgeons mean that access to care continues to be a challenge in Ontario.
CONCLUSIONS : Short birth length remains a risk factor for diabetes.
CONCLUSIONS : Shortened leukocyte telomere length demonstrates a significant association with stroke , myocardial infarction , and type @number@ diabetes mellitus.
CONCLUSIONS : Short-term outcomes were satisfactory , with low complication and mortality rates.
CONCLUSIONS : Short vertebral height without endplate fracture is equally prevalent in pre- and postmenopausal women and not associated with low bone density.
Conclusions : Signal-transduction proteins and early apoptosis proteins are associated with different clinical features and postsurgery outcomes.
CONCLUSIONS / SIGNIFICANCE : Based on these findings we conclude that age-related non-telomeric DNA damage accrual accompanies physiological stem cell aging in humans.
CONCLUSIONS / SIGNIFICANCE : HIV infection is associated with fragility fracture risk.
CONCLUSIONS / SIGNIFICANCE : It is hypothesized that latency and amplitude index different aspects of brain maturation.
CONCLUSIONS / SIGNIFICANCE : n-Butylidenephthalide may be one of the effective neuroprotective agents for PD.
CONCLUSIONS / SIGNIFICANCE : Our linkage data should facilitate the discovery of both common and rare variants that determine genetic variability in lifespan.
CONCLUSIONS / SIGNIFICANCE : SKI-II appears to be a novel activator of Nrf2 signalling via the inactivation of Keap1.
CONCLUSIONS / SIGNIFICANCE : The present study demonstrates that SEA promotes HSCs senescence through the FoxO3a / SKP2 / P27 pathway.
CONCLUSIONS / SIGNIFICANCE : These findings indicate that Gas7 is involved in motor neuron function associated with muscle strength maintenance.
CONCLUSIONS / SIGNIFICANCE : We here describe IgG glycoforms associated with calendar age at all ages and the propensity for longevity before middle age.
CONCLUSIONS : Significant age-related differences in orofacial muscle strength were observed mainly of the tongue musculature.
CONCLUSIONS : Significant changes occurred in the soft tissue facial profile from the second to fourth decades.
CONCLUSIONS : Significant differences in klotho gene rs9527025 and rs9536314 polymorphisms were found between the Uygur and Kazak populations.
CONCLUSIONS : Significant global structural alterations were identified in MCI and AD based on MANCOVA model with improved sensitivity.
CONCLUSIONS : Significant inequalities in the prevalence of chronic conditions , physical functioning and psychological distress persist into old age.
CONCLUSIONS : Simple changes in word usage may facilitate rapid and accurate communication regarding lasers , lights , and other energy devices.
CONCLUSIONS : Since age influences driving , the greater use compensatory strategies lessens the impact that aging has on this skill.
CONCLUSIONS : Since @number@ age-adjusted mean sleep duration has decreased slightly and the percentage of adults sleeping ≤ @number@ h increased by @percent@.
CONCLUSIONS : Single-tablet regimens are less likely to be prescribed in patients with polypharmacy.
Conclusions : Six months of physical activity resulted in improvements in body composition , subcutaneous fat , intermuscular fat , and strength measures.
CONCLUSION ( S ) : Skin characteristics of recently menopausal women are not well studied.
CONCLUSIONS : Sleep is associated with a significant decline in GnRH pulse frequency in both older and younger PMW.
Conclusions : Sleep / waking regulation and REM sleep regulation are disrupted in PSP , leading to profound sleep deprivation without recuperation.
CONCLUSIONS : Slower Timed Up and Go forecasted increased postoperative complications and 1-year mortality across surgical specialties.
CONCLUSIONS : Slow gait speed was thus an independent predictor of rapid cognitive decline in oldest-old men in a veterans ' retirement community in Taiwan.
CONCLUSIONS : Slowing of neuromuscular activation rate is associated with compromised dynamic muscle performance , which may contribute to mobility limitations in some older adults.
CONCLUSIONS : SMCs may reflect early , subtle cognitive changes and are associated with personality traits and meaning-in-life in healthy , older adults.
CONCLUSIONS : Smoking affects rectangularization more than longevity extension , both among men and women.
CONCLUSIONS : Smoking and SHS exposure impose a huge financial loss in Taiwan.
CONCLUSIONS : Smoking cessation may be associated with increased fat and muscle mass in postmenopausal women.
CONCLUSIONS : Smoking prevalence is relatively low among California Hispanics , but the economic impact is large because the population is large.
CONCLUSIONS : Smoking , previous cataract surgery and a family history of AMD are consistent risk factors for AMD.
CONCLUSIONS : Smoking status may be associated with a decline in processing speed , and this decline varies by sex.
CONCLUSIONS : Social cognition is distinctly impaired in schizophrenia compared to healthy aging.
CONCLUSIONS : Social desirability seems to contaminate the self-rating of psychological well-being in late adulthood.
CONCLUSIONS : Social network capital reduced the chances of smoking relapse.
CONCLUSIONS : Social skills appear to present an opportunity to maintain interaction with these residents.
CONCLUSIONS : Social strain may positively influence adaptive health promoting behaviors.
Conclusions : Social support and strain were associated with cognitive outcomes.
CONCLUSIONS : SOC in older adults is related to functional status , mental health status , personal wellbeing , and educational level.
CONCLUSIONS : Socioeconomic disparities in primary and secondary preventive services for patients with AMI could not be demonstrated in many instances.
CONCLUSIONS : Socio-economic status had a persistent effect on BP in this cohort born in @number@
CONCLUSIONS : SOD1 deficiency causes RGC vulnerability , which may be involved in the underlying condition of NTG.
CONCLUSIONS : Solanezumab at a dose of @number@ mg administered every @number@ weeks in patients with mild Alzheimer's disease did not significantly affect cognitive decline.
CONCLUSIONS : Solar elastosis was found in most patients with SCC and seems to indicate chronic severe solar damage.
CONCLUSIONS : Somatic mutations in the iron response elements ( IRE ) of the L-ferritin gene are infrequent in the age-related cataract.
CONCLUSIONS : Some older people still believe that physical activity is unnecessary or even potentially harmful.
CONCLUSIONS : Some patients with CKD experience physical and psychosocial frailty and feel ambivalent about prolonging life.
CONCLUSIONS : Some suprathreshold auditory processing abilities decline throughout adulthood , even when an individual's peripheral hearing is clinically normal.
CONCLUSIONS : Sonographic changes in healthy peripheral joints were observed predominantly in the oldest group.
CONCLUSIONS : Specific differences exist between young and older adults in amino acid metabolism.
CONCLUSIONS : Specific integrative therapies can be recommended as evidence-based supportive care options during breast cancer treatment.
CONCLUSIONS : Specific mutations in HBsAg C-terminus significantly correlate with HBV-induced HCC.
CONCLUSIONS : Spinal deformities in patients with osteoporosis are difficult to treat because of their debilitating and progressive nature.
CONCLUSIONS : S. sanguinis predominates over S. mutans in saliva of adults without caries experience.
CONCLUSIONS : ( S ) subjects appears more vulnerable than ( SO ) .
CONCLUSIONS : Statins may have multifactorial effects on dementia but not MCI risk.
CONCLUSIONS : Statin use was not associated with reduced mortality among CRC patients.
CONCLUSIONS : Statistically significant microstructural differences were found in the posterior sclera between African American and Caucasian donors.
CONCLUSIONS : Step training only in the forward direction improved stepping speed but may acutely slow response times in the untrained diagonal direction.
CONCLUSIONS : Stereotypes and expectations related to loneliness in the old age were significantly associated with reported loneliness @number@ years later.
CONCLUSIONS : Stochastic resonance training is feasible in untrained elderly resulting in good recruitment and compliance.
CONCLUSIONS : Strategies to minimize acetaminophen exposure , especially for HIV-monoinfected patients , are warranted.
CONCLUSIONS : Stroke and prestroke cognition were independently associated with increased probability of poststroke dementia.
CONCLUSIONS : Stroke educational campaigns have the potential to improve knowledge and awareness and change the behavior of a large number of people.
CONCLUSIONS : Stroke patients with a past history of cancer are at increased risk of recurrent stroke and cardiovascular mortality.
CONCLUSIONS : Stroke survivors have more participation restrictions than can be accounted for by sociodemographic profiles and comorbidity burden.
CONCLUSIONS : Stronger adherence to the Mediterranean diet may reduce the rate of cognitive decline among black , but not white older adults.
CONCLUSIONS : Studies for the collection of normal values have mainly involved young people.
CONCLUSIONS : Studies identified genetics and older age as key perceived risk factors more so than behaviors such as smoking.
CONCLUSIONS : Studies on self-medication in the elderly and its adverse health effects are clearly lacking.
CONCLUSIONS : Studies suggest that n-3 fatty acids in the diet and adherence to the MedDiet are beneficial in slowing age-related cognitive decline.
CONCLUSIONS : Study findings are informative for outdoor fall prevention programs as well as practice.
CONCLUSIONS : Studying gerontology abroad can widen views towards ageing and older adults , inspiring nurses to work in gerontological nursing.
CONCLUSIONS : Study limitations included the cross-sectional study design , the self-reported data , and the age of the data.
CONCLUSIONS : Subclinical atherosclerosis was highly prevalent in this middle-aged cohort , with nearly half of the participants classified as having intermediate or generalized disease.
CONCLUSIONS : Subgroup analyses show different trajectories between institutionalized and outpatients with schizophrenia.
CONCLUSIONS : Subjective memory worsening is reported by a minority of patients.
CONCLUSIONS : Subjects rating their health as poor / very poor at baseline were at increased risk of incident ET at follow-up.
CONCLUSIONS : Subjects with prevalent IHD and stroke exhibited lower LINE-1 methylation.
CONCLUSIONS : Substantial amyloid accumulation in cortical areas has already occurred before one meets criteria for a clinical diagnosis.
CONCLUSIONS : Substantial improvements in hypogonadal symptoms , quality of life , fatigue , erectile dysfunction , and libido / sexual desire were observed.
CONCLUSIONS : Substantial investments appear to be needed in Switzerland cancer services to meet and fill absolute increased demand driven by aging population.
Conclusions : Substantial variation exists in the mHAI across sociodemographic subgroups.
CONCLUSIONS : Substantial variation in the total free recall DDT scores but very little variation in the right ear-directed recall DDT scores was observed.
CONCLUSIONS : Successful Aging Inventory ( SAI ) is a reliable and adequate inventory , which can be used in Chilean older people.
CONCLUSIONS : Successful coping styles and good health predict high work ability , and thus , promoting such factors can help improve sustainable employability.
CONCLUSIONS : Supplemental CaD significantly increases 25OHD3 concentrations and decreases LDL-C.
CONCLUSIONS : Supplementation of antioxidants may prevent the oxidative injury in elderly group of subjects.
CONCLUSIONS : Surgical palliation can provide relief of obstructive symptoms as well as improved survival in well-selected patients , even if elderly.
CONCLUSIONS : Surprisingly , the effects of changes in height and lean body mass balance each other out in BMI calculation.
CONCLUSIONS : Survey non-participation in old age is likely to be associated with poor health and low alcohol consumption.
CONCLUSIONS : Survival bias can attenuate associations between harmful exposures and diseases of aging.
CONCLUSIONS : Survival for rare haematologic malignancies varied considerably by cancer entity.
CONCLUSIONS : Survival has substantially improved for head and neck cancer patients over the past decade.
CONCLUSIONS : Survival improved for patients with chronic leukemias in the early 21st century.
CONCLUSIONS : Survival of CHD patients undergoing CHLT is no different than in non-CHD , encouraging consideration of CHLT when clinically appropriate.
CONCLUSIONS : Survival of DCD donors is not shortened when compared with non-donor patients.
CONCLUSIONS : Survival outcomes were similar for both strategies.
CONCLUSIONS : Survivors of childhood ALL need careful dietary intervention to optimize long-term health.
CONCLUSIONS : Sustained physical activity in older age is associated with improved overall health.
CONCLUSIONS : Sustained physical activity is associated with improved survival and healthy ageing in older men.
CONCLUSIONS : SVAT is a useful test to assess executive functions , working memory and to discriminate between cognitive deterioration and normal aging.
CONCLUSIONS : svMCI patients show a deficit in orienting attention networks.
CONCLUSIONS : sweetness appears to be one of many factors contributing to the dislike of ONSs.
CONCLUSIONS : Synergistic interactions between specific inflammatory diseases may heighten the risk of frailty.
CONCLUSIONS : Systemic exposure following administration of armodafinil is increased in the elderly in comparison with younger subjects , particularly in those aged ≥75 years.
CONCLUSIONS : T2 cartilage mapping on MRI provides opportunity to exhibit biochemical and structural changes related with cartilage extracellular matrix without using invasive diagnostic methods.
CONCLUSIONS : Taken together , our data suggest that EMS could potentially be used as an anti-inflammatory and anti-aging treatment.
CONCLUSIONS : Taken together , our study shows expertise-dependent differences in task-related functional brain networks.
CONCLUSIONS : Taken together , present data highlight the modulation of hundreds of genes in the somatic components of KS patient testis.
CONCLUSIONS : Taken together , these results suggest that higher levels of education may attenuate an age-related reduction in neuronal viability in the frontal cortex.
CONCLUSION : Standardised , structured clinical interview is reliable for taking a history in community-dwelling older adults with self reported hand problems.
CONCLUSION : Standard metrics derived from PSG , including qEEG , contribute little to explaining subjective sleep quality in middle-aged to older adults.
CONCLUSION : ST and AT in patients with PD are associated with improved outcomes in disease symptoms and functional capacity.
CONCLUSIONS : T and cFT are lower in SA men than in WE and AC men.
CONCLUSIONS : Targetable mutations are uncommon in SCLC.
CONCLUSIONS : Taste and smell perception , particularly taste perception , were associated with a greater risk of frailty in community-dwelling elderly people.
CONCLUSIONS : TBAD probability increases with a larger aortic arch diameter and a longer thoracic aorta , whereas threshold values increase with age.
CONCLUSIONS : Tea consumption was associated with better physical functional performances in community-living older adults.
CONCLUSIONS : Tear-fluid amino acid profiles differ from those in plasma and aqueous humor.
CONCLUSIONS : Tear trough treatment by hyalurostructure shows satisfying and efficient results with few complications.
CONCLUSIONS : Technology acquirement by independent-living seniors may be best characterized as a heterogeneous process with many different origins , pathways and consequences.
CONCLUSIONS : Telomere length is positively associated with a robust lymphocyte response , and telomere attrition may contribute to the age-associated decline of adaptive immunity.
CONCLUSIONS : Tendo is a simple field method of determining muscular power among older adults and validation is essential.
CONCLUSIONS : Tendon transfers continued to provide pinch and grip function for individuals with tetraplegia for many years following spinal cord injury.
CONCLUSIONS : Tennis participation is associated with large side asymmetries in muscle and bone strength in old age.
CONCLUSIONS : Tennis players in the top @number@ show a biphasic career.
CONCLUSIONS : TERT mutation carriers exhibit early preclinical signs of lung fibrosis , bone marrow dysfunction , and premature graying.
CONCLUSIONS : Testing saccadic eye movements appears to be a promising and efficient method for screening large numbers of people such as elderly drivers.
CONCLUSIONS : Testosterone-induced increase in hemoglobin and hematocrit is associated with stimulation of EPO and reduced ferritin and hepcidin concentrations.
CONCLUSIONS : Testosterone level was related to both muscle mass , strength and physical performance.
CONCLUSIONS : TG , TC , LDL and HDL decreased significantly after @number@ weeks of progressive resistance exercise in old adults.
CONCLUSIONS : The 12-month individualized multicomponent rehabilitation program increased PA among older patients with hip fracture.
CONCLUSIONS : The 13-item and 10-item versions of PSS may be used to understand the experience of stress among older adults.
CONCLUSIONS : The 1-D model of the ageing tree and heart captures faithfully and with great accuracy the central pressure evolution with ageing.
CONCLUSIONS : The 1-year patient satisfaction ratings were higher for those treated with the lateral skin-platysma displacement technique.
CONCLUSIONS : The 2MCGA intervention shows strong delays in the decline of cognition and physical function for older residents with mild-to-moderate dementia.
CONCLUSIONS : The 3MS predicts functional decline , and this effect is a gradient effect.
CONCLUSIONS : The 40-item ISEL may be a useful measure for those studying social support in the context of CG.
CONCLUSIONS : The ≥65 year olds living in rural communities may need extra help with adherence to medicines for osteoporosis.
CONCLUSIONS : The ABC-6 and ABC-16 had excellent convergent validity , and both ABC scales had similar concurrent validity.
CONCLUSIONS : The absence of a gold standard for measuring standing balance has contributed to the proliferation of outcome measures.
CONCLUSION ( S ) : The abundance of functionally important transcripts exhibit marked oocyte-to-oocyte heterogeneity to a degree that is sufficient to affect protein expression.
CONCLUSIONS : The accuracy of the three anthropometric indexes is dependent on the choice of the reference method.
CONCLUSIONS : The ACFI does provide a small but not significant increase in funding to residents in residential care.
CONCLUSIONS : The active life style can positively affect the respiratory muscle strength and PCF values.
CONCLUSIONS : The adapted BNT appears to be the most suitable for use in the low-educated Brazilian population.
CONCLUSIONS : The ADC values of the spleen decline with age.
CONCLUSIONS : The addition of financial incentives to Smartcare was effective in increasing physical activity and reducing obesity.
CONCLUSIONS : The advanced schistosomiasis patents in Shanggao County decreases with years and shows an aging trend.
CONCLUSIONS : The adverse health effects of SHS exposure result in a large economic burden in China.
CONCLUSIONS : The African-American-white mortality gap for males is largely ameliorated ( @number@ years vs. @number@ years ) in professional basketball but still persists.
CONCLUSIONS : The age of transfused RBC units was independently associated with hospital mortality but not with 90-day mortality or KDIGO stage @number@ AKI.
CONCLUSIONS : The age related association with GFR estimates is smaller for creatinine estimates than for cystatin C estimates.
CONCLUSIONS : The age-related factors might play important roles in the development of IgAN.
CONCLUSIONS : The AGES @number@ Cohort Study provides useful evidence for research in social epidemiology , gerontology , and health services.
CONCLUSIONS : The aging process is complex , driven by a multitude of factors thought to modulate cellular and organism life span.
CONCLUSIONS : The AG was significantly associated with and an independent predictive factor for postoperative complications.
CONCLUSIONS : The allometric power model developed in this study best reflected the data and may be useful for dose adjustment.
CONCLUSIONS : The ambulatory monitoring better highlights the values of hypertension and assesses the LOAD and Day Index values.
CONCLUSIONS : The AMS scale and the three subscales had fairly good internal consistency and test-retest reliability.
CONCLUSIONS : The analyzed spatiotemporal gait parameters failed to predict recurrent falls in this sample.
CONCLUSIONS : The anatomy of the Indian population is distinct in that the palpebral fissure in men is less than that in women.
CONCLUSIONS : The angulation point of the BA becomes more acute in elderly individuals.
CONCLUSIONS : The appearance of age-related hand pigmentation characteristics were significantly improved at @number@ and @number@ weeks of treatment.
CONCLUSIONS : The appearance of primitive reflexes appears to be associated with the risk of malnutrition and developing aspiration pneumonia.
CONCLUSIONS : The application of MCI etiologic subtyping using pragmatic or conventional diagnoses leads to different results.
CONCLUSIONS : The association between benzodiazepine use and sleep quality is dependent on the half-life and prescribing pattern of the benzodiazepine.
CONCLUSIONS : The association between birth weight and intelligence is stable from young adulthood into midlife.
CONCLUSIONS : The association between cognitive functioning and sexual behavior in the aging population is understudied.
CONCLUSIONS : The association between meeting / not meeting the PA recommendation and MetS differed with method.
CONCLUSIONS : The association between social interactions and SRH varies between genders.
CONCLUSIONS : The association between testosterone and buccal TL supports gonadal maturation as a developmentally sensitive biomarker of aging within youth.
CONCLUSIONS : The association between WBC count and MetS was gender specific.
CONCLUSIONS : The associations between dietary indicators and obesity differed by sex.
CONCLUSIONS : The associations between older age and typical patient outcomes in HIV-positive patients from the Asia Pacific region are similar in AHOD and TAHOD.
CONCLUSIONS : The associations of myopia with prevalent nuclear and PSC cataract are confirmed in meta-analysis of @number@ study findings.
CONCLUSIONS : The associations of total and specific IgE levels with age and birth cohort were different.
CONCLUSIONS : The AS task is a useful measure of executive function across the AD spectrum.
CONCLUSIONS : The attenuation of estimates of association in patient cohorts is a much more substantial and complex issue than currently appreciated.
CONCLUSIONS : The authors believe that the rhytidectomy technique described in this report has several beneficial attributes.
CONCLUSIONS : The authors ' findings reveal a high prevalence of depression among KAE and a low level of mental health service utilization.
CONCLUSIONS : The authors found substantial symptom burden across disorders that increased with time and ultimately may undo initial treatment gains.
CONCLUSIONS : The authors proposed a reliable and reproducible grading system that may be used to investigate spinal kinematics in association with ISLD.
CONCLUSIONS : The authors report for the first time that increased brachial PP is an age-independently associated with WMLs in asymptomatic elderly individuals.
CONCLUSIONS : The authors suggest that VRMT may improve memory function in elderly adults by enhancing focused attention.
CONCLUSIONS : The automatic tool is promising and provides rapid assessment of brain volumes.
CONCLUSIONS : The average annual decline in MMSE score in DLB is approximately two points.
CONCLUSIONS : The average cpRNFL and GCC thicknesses measured using these @number@ instruments decreased with age.
CONCLUSIONS : The axis of lens astigmatism is close to the astigmatic axis of the anterior lens surface.
CONCLUSIONS : The basic structure of adventitial collagen fiber was maintained in abdominal aortas regardless of location or age.
CONCLUSIONS : The BDE model performed best for the estimation of remifentanil clearance and is realistic and of practical value.
CONCLUSIONS : The BE is independently associated with depression through land-use mix , and specifically through retail availability.
CONCLUSIONS : The Berlin questionnaire did not provide a high level of diagnostic specificity to discriminate OSA in an elderly population.
CONCLUSIONS : The best fits for the data are both logarithmic and double logarithmic functions.
CONCLUSIONS : The bioenergetic profile of mitochondria isolated from skeletal muscle is associated with gait speed in older adults.
CONCLUSIONS : The blunt cannula provided advantages in mitigation of pain and AEs , with a degree of correction similar to needle.
CONCLUSIONS : The bone mineral density of the coracoid process diminishes with age , thus confirming our hypothesis.
CONCLUSIONS : The brief PST-HC intervention demonstrated that depression improved among home care elderly.
CONCLUSIONS : The BY-VEP is sensitive to lenticular opacities of the human lens , presumably due to the increased short-wavelength absorption in the aging eye.
CONCLUSIONS : The Canadian long-term care sector is tied together through informal advice-seeking relationships that have given rise to an emergent network structure.
CONCLUSIONS : The CAVI scores increased with age in the healthy , normotensive individuals , whereas SBP , DBP and PP did not.
CONCLUSIONS : The CD4 : CD8 ratio in treated HIV-infected subjects with good immunovirological response is independently associated with markers of age-associated disease.
CONCLUSIONS : The Cdx2-GATA haplotype @number@ allele was related to increased mortality risk , which may be partly explained by osteoporotic fractures.
CONCLUSIONS : The CERAD-nb is capable of differentiating cases with mild AD from normal elderly individuals particularly with its verbal memory subtests.
CONCLUSIONS : The chance of establishing an etiologic diagnosis in patients presenting with a polyneuropathy decreases with age.
CONCLUSIONS : The chromosome 4q25 AF locus is architecturally complex and harbors at least @number@ AF susceptibility signals in individuals of European ancestry.
CONCLUSIONS : The circadian pattern of CAM can be quantified by @number@ cosine parameters of HRV , which are correlated with age and gender.
CONCLUSIONS : The circumstances and future of a given community's health should be kept in mind when policymakers plan for changes in medical education.
CONCLUSIONS : The classification models led to the identification of specific target groups at risk for memory complaints.
CONCLUSIONS : The clinical behavior of partial fixed dental prostheses with a zirconium dioxide core in the anterior region provides an adequate medium-term survival rate.
CONCLUSIONS : The clinical study demonstrated the safety and efficacy of the STOP home-use device for facial skin tightening.
CONCLUSIONS : The clonal HOXA9 / Meis1 AML model is amenable to drug screening analysis.
CONCLUSIONS : The cluster analysis attributed some of the variability in cardiorespiratory fitness among adolescents with complex ConHD to lifestyle behaviors and physical activity.
CONCLUSIONS : The cognitive composite is a highly reliable measure , with minimal floor and ceiling effects.
CONCLUSIONS : The cognitive profile of APOE ε4 carriers at mid-age remains elusive.
CONCLUSIONS : The collagen biomarkers PIIINP and ICTP , in part through pathophysiologically parallel associations with renal function , predicted ChrIRD and total death.
CONCLUSIONS : The combination of multiple HSDI analysis methods was effective in documenting the characteristics of vocal fold vibrations in VFA.
CONCLUSIONS : The combination of @percent@ niacinamide and 1%N-undecylenoyl phenylalanine is an effective anti-aging technology for use on facial skin.
CONCLUSIONS : The combination therapy is effective in decreasing the irritative and obstructive symptoms in patients with BPE than monotherapy.
CONCLUSIONS : the combination therapy of NgR vaccine and NSC transplantation exhibited significant advantages over any single therapy alone in this study.
CONCLUSIONS : The combined association of chronic disease and low skeletal mass with physical performance was stronger than the effect of either factor alone.
CONCLUSIONS : The combined intervention safely reduced drug use in very old inpatients and outperformed usual geriatric care.
CONCLUSIONS : The concept of age-friendliness has been garnering considerable attention from policy-makers as a way to promote healthy aging.
CONCLUSIONS : The conducted modern physiotherapy has a significant effect on the condition of patients after surgery.
CONCLUSIONS : The considerable variation in repeatability and reproducibility should be taken into account when using the Corvis.
CONCLUSIONS : The construct validity and reliability of the IPAFin is acceptable.
CONCLUSIONS : The COPE Index is a valid and reliable screening tool to measure negative impact and quality of support of caregivers of disabled people.
CONCLUSIONS : The cost of management of HFpEF was enormous and further increased in the presence of comorbidities.
CONCLUSIONS : The country comparison reflects major public policy differences underpinned by divergent political and ideological frameworks.
CONCLUSIONS : The course of disability in the year before hospice differs greatly among older persons but is particularly poor among those with neurodegenerative disease.
CONCLUSIONS : The crude incidence of CRC increased significantly between @number@ and @number@ because of the aging , whereas the ASRs kept stable.
CONCLUSIONS : The CSES demonstrated adequate reliability and validity for assessing a community's self-efficacy to aid in its preventing social isolation among older people.
Conclusions : The CT generally decreased with age , but it decreased much faster in old age than in relatively younger people.
Conclusions : The current results demonstrate that both PD and normal aging affect retention of speech motor learning.
CONCLUSIONS : The current results indicate that a variety of medical conditions adversely affects cognition.
CONCLUSIONS : The current study demonstrated the in vivo interrelationship between the organic constituents , remodeling , and damage formation in cortical bone.
CONCLUSIONS : The current study highlights how the brain might mediate the tendency to preferentially engage in positive information processing in healthy aging.
CONCLUSIONS : The current study provides evidence for an association between sleep quality , sleep duration , and cellular aging.
CONCLUSIONS : The current study results suggest that the A / G ratio is related to cognitive decline and may reflect homeostatic alterations.
CONCLUSIONS : The current study revealed an increase in disability from @number@ to @number@ in the older Spanish population.
CONCLUSIONS : The current study showed an advancing trend in PGA in both Chinese boys and girls.
CONCLUSIONS : The current use of OAC in European AF patients was satisfactorily high in octogenarians , suggesting reasonable implementation of current guidelines.
CONCLUSIONS : The CVL concept can be applied to a health care system , providing a measure of health care quality.
CONCLUSIONS : The data indicate that both SLI and N-SLI represent significant risk factors for all the outcomes identified.
CONCLUSIONS : The data indicate that cohesin declines gradually during the long prophase arrest that precedes MI in female mammals.
CONCLUSIONS : The data obtained confirm the epidemiological impact of HZ and its complications and the need of a preventive approach.
CONCLUSIONS : The DBS-based HbA1c values are highly correlated with venous results.
CONCLUSIONS : The D & CM intervention was effective in controlling cardiovascular risk factors , in particular hypertension and diabetes.
CONCLUSIONS : The decrease in GDF11 may be involved in the cellular senescence observed in COPD.
CONCLUSIONS : The decrease in mean UBT values already occurs during the first decade of life , and results increase following the sixth decade.
CONCLUSIONS : The degradation of the small-angle domain of the point-spread function after DSEK suggests that aberrations contribute to decreased visual acuity after DSEK.
CONCLUSIONS : The depressive symptoms scales in these four studies measured depression in the same way , regardless of cognitive status.
CONCLUSIONS : The design of the partial retainer significantly influences the failure load and type of selective infiltration-etched zirconia restorations.
CONCLUSIONS : The developed framework provides novel insights in COPD and especially COPD co-morbidity associated mechanisms.
CONCLUSIONS : The diagnosis of multiple chronic conditions , can be used to identify those most at risk of severe disability.
CONCLUSIONS : The diagnostic performance of invasive physiological indices showed no differences in the prediction of myocardial ischemia defined by CFR.
CONCLUSIONS : The diagnostic value of apparent age depends on how many years older than his or her actual age a patient looks.
CONCLUSIONS : The difference in falls among stroke survivors and matched controls is largely explained by known risk factors and physical capacity.
CONCLUSIONS : The difference in sepsis mortality between urban and rural areas decreased over time.
CONCLUSIONS : The different bereavements did not predict mortality risk while an indirect link was found showing that mortality risk decreased with time.
CONCLUSIONS : The dimensions of the maxillary sinus are influenced by age and edentulism status being reduced by aging and tooth loss.
CONCLUSIONS : The disadvantage in tooth loss is persistent in Appalachia and growing in the Mississippi Delta.
CONCLUSIONS : The distribution of central corneal thickness among this American Chinese population is similar to that reported in studies from East Asia.
CONCLUSIONS : The distribution of the C1367T WRN polymorphism in patients with senile cataract is similar to that in the normal population.
CONCLUSIONS : The distribution patterns of skin diseases in a Veterans Home were unique.
CONCLUSIONS : The dominant framing portrays individual workers as ingenious , determined , and successful.
CONCLUSIONS : The D-SAFE was developed as a more comprehensive tool specifically designed for GAU inpatients.
CONCLUSIONS : The early experience with TECS has been promising.
CONCLUSIONS : The economic burden of FTD is substantial.
CONCLUSIONS : The economic impact of SHS exposure in the home totalled $ 360 million in California in @number@
CONCLUSIONS : The effectiveness of the various treatments for cervical spine degenerative disorders is influenced by the overall anatomical conditions of the cervical spine.
CONCLUSIONS : The effect of stroke on dementia incidence in the population is not explained by common risk factors.
CONCLUSIONS : The effects of age and RTS on inhospital mortality of patients after ground-level falls differed by sex.
CONCLUSIONS : The effects of cocultured adipocytes on myocyte substrate selection and insulin action depended on the metabolic state of the system.
CONCLUSIONS : The effects of older age extend to other important outcome measures after CRC procedures beyond operative mortality.
CONCLUSIONS : The efficacy and safety of MT10109L were comparable to those of Botox for the management of glabellar frown lines.
CONCLUSIONS : The elderly requiring care had a relative expansion of extracellular water in the legs , which could have masked actual muscle atrophy.
CONCLUSIONS : The EOS technology proved to be an appropriate method to measure lower limbs anatomical parameters in children.
CONCLUSIONS : The epithelium and the Bowman's layer were not evenly distributed across the horizontal meridian of the cornea.
CONCLUSIONS : The equilibrium bleach was more reliable and repeatable than the photoflash.
CONCLUSIONS : The estimated total costs corrected for treatment gap were €1.15 to €1.64 billion.
CONCLUSIONS : The evidence of a positive correlation between lower urinary tract symptoms and erectile dysfunction is significant in community- and clinical-based studies.
CONCLUSIONS : The evidence suggests Pilates can improve balance , an important risk factor for falls in older adults.
CONCLUSIONS : The evidence supports the view that drivers with cognitive impairment do restrict their driving and avoid complex driving situations.
CONCLUSIONS : The evidence to date is insufficient to determine whether facial exercises are effective for facial rejuvenation.
CONCLUSIONS : The excitability indices may be interchangeable for sensory axons but not motor axons.
CONCLUSIONS : The experience of discrimination is common among older adults and is associated with poorer physical and cognitive functioning.
CONCLUSIONS : The exposure of IDeg at steady state during once-daily dosing was similar in younger adult and elderly subjects.
CONCLUSIONS : The expression of inflammation mediator is abnormal in aged mice with more serious periodontal lesions than youth mice.
CONCLUSIONS : The FACE-Q Aging Appraisal Scale and Patient-Perceived Age VAS are psychometrically sound , condition-specific PRO instruments with excellent reliability and validity.
CONCLUSIONS : The FA in the subcortical white matter area reduces earlier than that in deep white matter.
CONCLUSIONS : The finding may shed light for possible response-guided-therapy for so-called ultra-super-responders in the DAA era.
CONCLUSIONS : The findings are consistent with a view of resilience as a protective factor that supports optimal functioning in people aging with disability.
CONCLUSIONS : The findings extend previous research on the potential usefulness of the VACS Index in predicting HIV-associated outcomes to include NCI.
CONCLUSIONS : The findings from this study did not show any decrease in interhemispheric coherence for the alpha band in cognitively normal nonagenarians.
CONCLUSIONS : The findings highlight the multifaceted , complex pathway to NHA for persons with dementia and their family caregivers.
CONCLUSIONS : The findings in the present study indicate that changes in PGS may precede and potentially directly impact changes in PTS following bereavement.
CONCLUSIONS : The findings lend additional support to the holistic model and help to understand how subjective well-being and MIL correlate with adaptation to stress.
CONCLUSIONS : The findings of the present study suggest that communication should focus on health-related benefits other than fish consumption alone.
CONCLUSIONS : The findings of this review confirm the potential of motion-based technology to improve the lives of people living with dementia or MCI.
CONCLUSIONS : The findings of this study suggest that musculoskeletal pain in nonagenarians is highly prevalent and is associated with poor physical performance and disability.
CONCLUSIONS : The findings reinforce public health recommendations promoting behavior modification and specifically moderate-intensity exercise in middle-aged and older adults.
CONCLUSIONS : The findings show that the association between vitamin D and physical performance remains controversial.
CONCLUSIONS : The findings suggested that predisposing , intra-individual , and extra-individual factors play different roles in the development of later disability trajectories.
CONCLUSIONS : The findings suggest that IGF-I and II concentrations decline with age , and greater declines are associated with higher fat mass levels.
CONCLUSIONS : The findings suggest that inhibitory functioning remains intact in older adults under the age of @number@ years.
CONCLUSIONS : The findings suggest that less-than-ideal CVH is associated with shorter LTL , but this association varies by sex and race / ethnicity.
CONCLUSIONS : The findings suggest that the relationship of eating frequency with BMIz differs from that of change in BMIz.
CONCLUSIONS : The findings support the conclusion that individuals with SCI show signs of ' premature aging ' in different organ systems.
CONCLUSIONS : The findings support the roles of antioxidant vitamins and n-3 PUFA in the pulmonary health of older persons.
CONCLUSIONS : The findings were generally consistent across the AMI and AI.
CONCLUSIONS : The five-step neck lift helps to optimize results in creating the ideal neck contour.
CONCLUSIONS : The FLSQ is a valid questionnaire for assessing treatment expectations , satisfaction , impact , and preference in adults with UFL.
CONCLUSIONS : The frequency of masked hypertension was high in our study sample.
CONCLUSIONS : The future burden of disease due to smoking is expected to be reduced among men , but not yet among women.
CONCLUSIONS : The genetic mutation in GJA3 , GJA8 , and LIM2 may slightly contribute to the development of age-related cataracts.
CONCLUSIONS : The genetic variants of Klotho might predict risk for metabolic syndrome and insulin resistance in Asian Indians.
CONCLUSIONS : The ' Getting to Know Me ' programme was well received and had a significant impact on staff knowledge and confidence.
CONCLUSIONS : The GGS is a reproducible method of grading the severity of NLF wrinkles.
CONCLUSIONS : The Gompertz function provides estimates of the age and the amount of myopia at stabilization in an ethnically diverse cohort.
CONCLUSIONS : The grip strengths obtained from the three positions were not all comparable in our community-dwelling older adults.
CONCLUSIONS : The group of older controls had poorer and more variable RTs and accuracies than the young controls.
CONCLUSIONS : The HDS was confirmed to be as accurate in predicting the degree of degeneration in the cervical spine as in the lumbar region.
CONCLUSIONS : The heterogeneity of these results strongly suggests the multidimensionality of SA and the difficulty in categorizing usual versus successful aging.
CONCLUSIONS : The higher field and T2WI more sensitively detect subtle changes in the deep white matter and perivascular spaces in particular.
CONCLUSIONS : The high interindividual variations of ' p ' and ' t ' render the use of reference values problematic.
CONCLUSIONS : The host response and outcome in male and female sepsis patients requiring ICU admission are largely similar.
CONCLUSIONS : The human ciliary muscle undergoes age-dependent changes in morphology that suggest an antero-inwards displacement of muscle mass , particularly in emmetropic eyes.
CONCLUSIONS : The human heart is a highly dynamic organ regulated by a pool of resident hCSCs that modulate cardiac homeostasis and condition organ aging.
CONCLUSIONS : The hypercoagulable states are common in young patients with ischaemic stroke , being present in up to @percent@ of them.
CONCLUSIONS : The IBD population older than age @number@ at the time of initiation of anti-TNF therapy is at higher risk for discontinuation of therapy.
CONCLUSIONS : The \ "ICU-RESPECT \ " index demonstrates high reliability and concurrent validity in ICU patients and families.
CONCLUSIONS : The immunochemical FOBT in our study was more sensitive for detecting subjects with left- vs right-sided advanced colorectal neoplasia.
CONCLUSIONS : The impact of age-related cataract on DVA was more severe than its effects on static visual acuity.
CONCLUSIONS : The impact of anticholinergic discontinuation on cognitive function remains poorly researched and poorly understood.
CONCLUSIONS : The importance of binocular vision for eye-hand coordination normally increases with age and use of online movement guidance.
CONCLUSIONS : The incidence of amyloid PET positivity is approximately @percent@ per year among CN participants over age @number@ sampled from a population-based cohort.
CONCLUSIONS : The incidence of diagnosed prostate cancer in patients with renal transplant will increase because of systematic PSA screening.
CONCLUSIONS : The incidence of lens extraction has increased over the past @number@ years in persons older than @number@ years.
CONCLUSIONS : The incidence of MACE in Chinese elderly patients with CAD who underwent non-cardiac surgery was @percent@.
CONCLUSIONS : The incidence of MCR is high in older adults.
CONCLUSIONS : The incidence of thyroid dysfunction is markedly less than would be expected from prevalence studies.
CONCLUSIONS : The incidence of VHD and CAD showed a significant conflicting relationship.
Conclusions : The incidence of VI and blindness in this older Kenyan population was considerably higher than in comparable studies worldwide.
CONCLUSIONS : The increased MSDs reported by bridge employed adults may be the result of irregularity of work activity and soft tissue loading.
CONCLUSIONS : The indication to leave the bladder in situ requires individual considerations.
CONCLUSIONS : The inexistent of the caregiver's profile , their absence or inability to care was predictive of institutionalization.
CONCLUSIONS : The information provided in this review should serve as a foundation for investigators new to the field of resting-state functional connectivity.
CONCLUSIONS : The intellectual challenges are important factors for physicians in China influencing the pursuit of careers in the clinical neurosciences.
CONCLUSIONS : The intensity in achieving aerobic exercise is associated with physical fitness and cognitive performance.
CONCLUSIONS : The interRAI Home Care Frailty Scale is based on a strong conceptual foundation and in our analysis , performed as expected.
CONCLUSIONS : The intrinsic material properties of root dentine have spatial variations , and they are altered by ageing.
CONCLUSIONS : The introduced model is mathematically consistent with known physiology and can reproduce variations in immune status and allograft survival after transplantation.
CONCLUSIONS : The inverse association between gait speed and depressive symptoms appears to be bidirectional.
CONCLUSIONS : the ISAR-HP can readily distinguish well-functioning older patients from patients with low functioning and low HRQoL after hospital admission.
CONCLUSIONS : The Japanese version of the ADOC is a valid and reliable instrument for measuring client satisfaction with individualized occupational performance.
CONCLUSIONS : The key factors to understanding HRQoL among Latin American-born immigrants settled in Spain are age , sex and social support.
CONCLUSIONS : The Korean Framework for Senior-Friendly Hospitals needs to include @number@ Chapters , @number@ categories , and @number@ standards.
CONCLUSIONS : The lack of content surrounding grief represents a gap for this population at high risk for complicated grief and chronic sorrow.
CONCLUSIONS : The LASSI-L is a reliable and valid test for the diagnosis of aMCI and mild AD.
CONCLUSIONS : The LCC impacts the rate of decline in eGFR.
CONCLUSIONS : The legal needs and rights of persons with dementia are much broader than issues of legal capacity or social protection.
Conclusions : The lens power in children and adolescents aged @number@ to @number@ years exhibited three stages.
CONCLUSIONS : The level of physical activity seems to be related to work ability.
CONCLUSIONS : The likelihood of being listed for transplant falls with increasing age at the time of starting RRT.
CONCLUSIONS : The literature demonstrated that BMP serves as a potent osteoinductive agent in the elderly with similar efficacy to bone autograft.
CONCLUSIONS : The locally-adapted CDSMP may improve self-management behaviours , self-efficacy and health status among older adults with chronic diseases in Hong Kong.
CONCLUSIONS : The lowering the lower eyelid procedure offers Asian patients desiring large oval eyes a novel surgical option.
CONCLUSIONS : The macular choroidal thickness and volume in the pediatric individuals were significantly larger than those in the adults.
CONCLUSIONS : The magnitude of the decrease in concentrations is a better predictor of LOH than are the actual concentrations of T and BT.
CONCLUSIONS : The main advantage of this surgical technique is preserving continuity of the orbicularis oculi muscle while selectively decreasing muscle tone.
CONCLUSIONS : The majority of hand surgeons in the US use trapeziectomy with LRTI as the surgical treatment of choice for thumb CMC arthritis.
CONCLUSIONS : The majority of men have heard of a male climacteric , but only a minority had consulted a practitioner about their symptoms.
CONCLUSIONS : The majority of participants were willing to share their HIV status.
CONCLUSIONS : The majority of studies included hospitalizations as a secondary outcome.
CONCLUSIONS : The majority of TB deaths were ascribed to non-TB-related causes.
CONCLUSIONS : The majority of women aging out of the GA BCCP 2000-2005 had used the program to obtain regular mammography.
CONCLUSIONS : The majority of women with tuberculosis in the Mazovian district are single , over @number@ years old , unemployed inhabitants of cities.
CONCLUSIONS : The Male OPAQ ( TM ) is a brief and sensitive tool for measuring HRQOL in men with OP.
CONCLUSIONS : The MAR was independently and significantly inversely associated with CRP , suggesting diet is associated with the regulation of inflammation.
CONCLUSIONS : The MAT-sf is a quick and efficient way of identifying older adults at risk for MMD.
CONCLUSIONS : The MAT was sensitive to cognitive decline in older adulthood.
CONCLUSIONS : The mean intervertebral foraminal area was greater in the lower cervical region than the upper in normal adult individuals.
CONCLUSIONS : The measure of resilience is useful in screening high-risk employees who are vulnerable to stress.
CONCLUSIONS : The mechanism by which longevity-associated alleles of FOXO3 reduce age-related mortality is currently of great clinical interest.
CONCLUSIONS : The menopausal symptoms resulting from hypoestrogenism in natural postmenopausal women are mostly remarkable.
CONCLUSIONS : The method places minimal demands on observers.
CONCLUSIONS : The MF-EMG fatigue method is able to elucidate alterations of aging back muscles.
CONCLUSIONS : The Mini and 7D-PAR provided reasonably valid estimates of TEE but large errors in estimating AEE.
CONCLUSIONS : The minimally invasive TLIF through paramedian approach with unilateral pedicle screw fixation is an effective and convenient method with little surgical trauma.
CONCLUSIONS : The mitochondrial haplogroups A and M7a confer a significant risk for coronary atherosclerosis in the Japanese.
CONCLUSIONS : The MNA-SF appears to be an accurate predictor of one-year mortality in nursing home residents.
CONCLUSIONS : The mortality for CVD increased with time and aging.
CONCLUSIONS : The mSCDDL procedure was a promising tool in assisting early diseases diagnosis using neuroimaging data.
CONCLUSIONS : The MSCs derived from human iPSCs with our method have advanced proliferation capability and adequate osteogenic and chondrogenic properties compared to BM-MSCs.
CONCLUSIONS : The multifaceted podiatric medical intervention used in this trial was generally perceived to be beneficial and demonstrated high levels of satisfaction among participants.
CONCLUSIONS : The MUST can be used as a minimal invasive procedure for facial rejuvenation with a short downtime and low complication rate.
CONCLUSIONS : The mutual recovery program could be a creative and effective approach to improve mental health in older community-dwelling adults with depressive symptom.
CONCLUSIONS : The nCMSP represents a potential risk factor for falls in older adults with NMF.
CONCLUSIONS : The need for new initiatives in research into ageing in ASD is urgent.
CONCLUSIONS : The need for valvular interventions has increased in the last two decades in congenital heart disease patients.
CONCLUSIONS : The Nefertiti lift can be used on its own or in conjunction with other rejuvenating procedures.
CONCLUSIONS : The negative impact of comorbidity on QoL might be mitigated by promoting a positive self-perception of aging in older people.
CONCLUSIONS : The new criteria for AD are presented in three documents.
CONCLUSIONS : The newly derived models provide a personalized prediction of long-term success from early weight-loss variables.
CONCLUSIONS : The new protocol seems to be promising in reducing the risk of falling of elderly subjects.
CONCLUSIONS : The NI-BUT values found in this study are much lower than those of previous reports.
CONCLUSIONS : The nocturnal increase of S4 in the elderly reflects diastolic impairment-likely a result of changes in diastolic filling patterns with increasing age.
CONCLUSIONS : The normalized-rCMRglc values in specific regions were associated with individual differences in gait function , even in healthy older women.
CONCLUSIONS : The normative data obtained will be extremely useful in the clinical neuropsychological evaluation of young Spanish adults.
CONCLUSIONS : The norms obtained will be extremely useful in the clinical evaluation of young Spanish adults.
CONCLUSIONS : The NRP-e improved a range of CVD risk factors.
CONCLUSIONS : The @number@ , 5-diaryl-3-oxo-1 , 4-pentadiene analogs can yield good lead compounds for cancer chemotherapy , to overcome low bioavailability of curcumin.
Conclusions : The number of insomnia symptoms predicts 2-year fall risk in older adults.
CONCLUSIONS : The number of medications used by older adults in this convenience sample was associated with poorer nutritional status.
CONCLUSIONS : The @number@ smoke-free policy reduced the SHS exposure for non-smokers.
CONCLUSIONS : The observed gait improvements add to the understanding of the self-reported unspecified improvements among MCI patients when treated with standardised GBE.
CONCLUSIONS : The observed lower BMI in ET is consistent with the neurodegenerative hypothesis of ET.
CONCLUSIONS : The obtained data show that a decrease exists in the speed processing in the elderly group.
CONCLUSIONS : The obtained results indicated very high reliability and accuracy for the Polish adaptation of the SPA.
CONCLUSIONS : The obtained results suggest an aging-associated downregulation of angiopoietins / Tie-2 system and an apparent compensatory upregulation of the VEGF / KDR system.
CONCLUSIONS : The occurrence of HTN was high and was strongly associated with diabetes , the aging process and obesity.
CONCLUSIONS : The opacifier protects facial silicones against color degradation , and oil paint is a stable pigment even without addition of opacifier.
CONCLUSIONS : The operative mortality was high and should be reassessed.
CONCLUSIONS : The option of avoiding relocation was highly valued by participants compared with private rooms and individualized care.
CONCLUSIONS : The outcomes of each model of care differ and correspond to the model's focus.
CONCLUSION ( S ) : The ovarian volume and follicle number threshold to define polycystic ovary morphology should be lowered starting at age @number@
CONCLUSIONS : The overall current literature suggests that smoking was associated with increased risk of ARC , especially NC.
CONCLUSIONS : The PA intervention increased PA by shifting the composition of activity toward higher-intensity activity in longer-duration bouts.
CONCLUSIONS : The papillomacular bundle RNFL of ADOA is most vulnerable and progressively damaged with age , despite early temporal RNFL loss.
CONCLUSIONS : The Parkinson's Progression Marker Initiative study and its genetic data are useful in studies of PD biomarkers.
CONCLUSIONS : The pattern of FLAIR / DWI hyperintensity and restricted diffusion can differentiate sCJD from other RPDs with a high sensitivity and specificity.
CONCLUSIONS : The pattern of grieving for some family members of NH residents with advanced dementia is prolonged and begins before resident death.
CONCLUSIONS : The patterns of age-dependent decreases in physical performance measures differed among parameters and between sexes.
CONCLUSIONS : The PCA and discriminant function analysis applied in this investigation identified gait pattern differences between young and older adults.
CONCLUSIONS : The performance of gFOBT under routine screening conditions is even worse than previously estimated from clinical studies.
CONCLUSIONS : The peripheral visual field declined substantially from the 4th decade onward while the central visual field remained quite stable.
CONCLUSIONS : The physical phenotype of frailty appears of limited clinical use for risk stratification of older medical inpatients.
CONCLUSIONS : The pilot study met all the requested goals.
CONCLUSIONS : The plasma concentration of miR-126 was negatively correlated with age and NYHA class , and could be a useful biomarker for heart failure.
CONCLUSIONS : The plasma level of d-ROMs is associated with AAC in patients with type @number@ diabetes but without cardiovascular disease.
CONCLUSIONS : The PLFI is a valid tool for assessing frailty in the HRS data set.
CONCLUSIONS : The PMT and PD are age dependent parameters.
CONCLUSIONS : The point-spread-function of the normal ageing and cataractous human eye is built upon two rather independent basic parts.
CONCLUSIONS : The poor methodological quality of the included studies implies that the ability to draw conclusions is limited.
CONCLUSIONS : The positivity prevalence of TT and CSM in patients with unexplained falls compared to patients with unexplained syncope is similar.
CONCLUSIONS : The possible relation between anesthetic neurotoxicity , postoperative cognitive dysfunction , and AD remains elusive.
CONCLUSIONS : The postblepharoplasty look of patients undergoing secondary upper lid blepharoplasty differs from the lid appearance of patients presenting for primary blepharoplasty.
CONCLUSIONS : The prediction score has useful prediction accuracy.
CONCLUSIONS : The predictors of work disability vary by age and diagnosis.
CONCLUSIONS : The presence of contextually related non-target items produces both positive and negative effects on ADL performance.
CONCLUSIONS : The presence of sarcopenia could be detected using three easily obtainable variables with high accuracy.
CONCLUSIONS : The presence of StCA at high titres can be considered a good predictive marker of subsequent development of autoimmune POI.
CONCLUSIONS : The present cohort had excellent renal outcomes after radiation therapy for neuroblastoma.
CONCLUSIONS : The present data indicate that task importance is one of the factors determining the presence or absence of age deficits in prospective remembering.
CONCLUSIONS : The present data of master athletes are compatible with the hypothesis of an age-related decline in whole body muscle mass and motor units.
CONCLUSIONS : The present data provide new evidence that serum concentration of Hsp70 decreases with age in a normal population.
CONCLUSIONS : The present data suggests FADD as a putative biomarker for pathological processes associated with the course of clinical dementia.
CONCLUSIONS : The presented core set is a secure , fast , and accurate instrument for assessing the physical health and engagement of older adults.
CONCLUSIONS : The present findings suggest that CCR is a promising strategy for prevention and treatment of sarcopenia in patients with CVD.
CONCLUSIONS : The present longitudinal study suggests that over adulthood , the multifidus and erector spinae undergo similar morphological changes.
CONCLUSIONS : The present meta-analysis indicated the efficacy of NRT- and varenicline-assisted reduction to achieve complete cessation among smokers without an intention to quit.
CONCLUSIONS : The present paper showed the epidemiology of sarcopenia , and the strong connection to functionality indicators.
CONCLUSIONS : The present results showed a decrease of the output parameters of the explosive grip force test in older women.
CONCLUSIONS : The present results suggest that ADT use is associated with an increased risk of developing AD.
Conclusions : The present results suggest that unaffected siblings may present accelerated aging features.
CONCLUSIONS : The present study confirms an earlier finding that variation in the AMHR2 gene modifies the relation between parity and age at natural menopause.
CONCLUSIONS : The present study confirms that barriers to food intake are common in acute care hospitals.
CONCLUSIONS : The present study demonstrated that the human NPCs had a finite in vitro lifespan , which declined with host aging.
CONCLUSIONS : The present study demonstrates that IPL irradiation imparts stimulatory effects on skin fibroblasts in vitro.
CONCLUSIONS : The present study demonstrates that patients with cirrhosis had biventricular dilatation and impaired biventricular systolic strain compared with controls.
CONCLUSIONS : The present study demonstrates the complex interplay between psychache and resilience.
CONCLUSIONS : The present study documents the influence of cortisol secretion on hPER1 gene expression in older women.
CONCLUSIONS : The present study found a higher prevalence of depression in the Chinese older population compared with those reported two decades ago.
CONCLUSIONS : The present study further informs our understanding of the disparate functional neuroanatomy of recency memory and recognition memory in AD.
CONCLUSIONS : The present study increases the external validity of dual-task gait assessment of MCI.
CONCLUSIONS : The present study indicated that Ginsenoside Rb1 acts through stimulating Sirt1 in order to protect against endothelial senescence and dysfunction.
CONCLUSIONS : The present study indicates that twice-weekly ME has a limited effect on isokinetic muscle strength.
CONCLUSIONS : The present study on middle-aged to older individuals showed age-related decline in inhibition and switching abilities.
CONCLUSIONS : The present study provides evidence that tongue disability and age can influence behavioral measures of tongue motor performance.
CONCLUSIONS : The present study showed that sensorimotor gating , as measured with PPI , is markedly reduced in MSA.
CONCLUSIONS : The present study shows the important role of attentional preferences in older adults ' social network maintenance.
CONCLUSIONS : The present study suggests that a polymorphism in XPD codon @number@ may be associated with the development of maturity onset cataract.
CONCLUSIONS : The present study suggests that raised postoperative cytokine concentrations are associated with delirium after CABG surgery.
CONCLUSIONS : The present technique has proven simple and effective in a small cohort over two years.
CONCLUSIONS : The prevalence and total cost for subdural hematoma has increased significantly in the last decade nationwide.
CONCLUSIONS : The prevalence of anemia in older adults was @percent@ and was mainly associated with advanced age and presence of chronic diseases.
CONCLUSIONS : The prevalence of ATR astigmatism was high in this study.
CONCLUSIONS : The prevalence of blindness and visual impairment in Peru is similar to that of other Latin American countries.
CONCLUSIONS : The prevalence of cirrhosis and HCC in HCV-infected patients has increased significantly over the past @number@ years.
CONCLUSIONS : The prevalence of complex plaque was not low in the this Japanese study population.
CONCLUSIONS : The prevalence of disability in basic ADLs among Chinese older adults decreased from @number@ to @number@
CONCLUSIONS : The prevalence of dry eye and its associated risk factors in the BOSS were similar to previous studies.
CONCLUSIONS : The prevalence of dry eye in female is higher than that in the male.
CONCLUSIONS : The prevalence of ERM was @percent@ and of idiopathic ERM @percent@.
CONCLUSIONS : The prevalence of frailty is highly dependent on the diagnostic tool used.
CONCLUSIONS : The prevalence of glaucoma from NHANES based on ISGEO criteria produces similar population estimated to other population-based studies.
CONCLUSIONS : The prevalence of hearing loss increases with age and the presence of DM.
CONCLUSIONS : The prevalence of hip OA in elderly Korean was @percent@ ( JSW < or = 2mm ) in community-based population.
CONCLUSIONS : The prevalence of H. pylori infection increases with age and exhibits geographic variation in Japan.
CONCLUSIONS : The prevalence of low BMD in vertically HIV-infected patients was low after height adjustment.
CONCLUSIONS : The prevalence of major CRFs of ≥ @number@ yrs resident from Beijing communities are higher than the average level of China.
CONCLUSIONS : The prevalence of MCI in elderly Chinese is higher in rural than in urban areas.
CONCLUSIONS : The prevalence of MetS among men aged @number@ years and over was @percent@ , and the 3-year mortality rate was @percent@.
CONCLUSIONS : The prevalence of missing teeth , use of bridges and dentures and unmet dental needs were high in the SABE cities in 1999-2000.
CONCLUSIONS : The prevalence of nail changes and disorders has increased among elderly patients although they are frequently overlooked by health care providers.
CONCLUSIONS : The prevalence of OAB increased with aging of the community-based male population.
CONCLUSIONS : The prevalence of optimal cardiac health is low in this cohort.
CONCLUSIONS : The prevalence of OSA in patients with chronic wounds exceeds the estimated prevalence of OSA in the general middle aged population.
CONCLUSIONS : The prevalence of presarcopenia and sarcopenia was high in hip-fracture women.
CONCLUSIONS : The prevalence of SA in this study ( @percent@ ) is comparable to previous studies.
CONCLUSIONS : The prevalence of sarcopenia in community-dwelling older adults is comparable with those in other populations.
CONCLUSIONS : The prevalence of sarcopenia is high either based on RASM or SMI among Chinese men aged @number@ years and older.
CONCLUSIONS : The prevalence of spirometric obstructive pattern was high.
CONCLUSIONS : The prevalence of the metabolic syndrome was high and was not associated with poor sexual function in this sample of menopausal women.
CONCLUSIONS : The prevalence was relatively low in older people of Chongqing , Southwest China.
CONCLUSIONS : The primary treatment of borderline ovarian tumors refers to conservative surgery.
CONCLUSIONS : The Pro12Ala polymorphism is associated with TL homeostasis after @number@ years follow-up in subjects at high cardiovascular risk.
CONCLUSIONS : The problem of creating a general frailty index is still unsolved.
CONCLUSIONS : The procedure of local ischemia , although reulting in a preserved endothelial reactivity , did not mobilize ECFCs but altered their angiogenic potential.
CONCLUSIONS : The profiles of attributes that are associated with self-reported vs. observed walking ability differ.
CONCLUSIONS : The programme's successful implementation provides evidence that reliance on theory is critical in planning and developing effective community-based programme interventions.
CONCLUSIONS : The proportion of elderly persons relocating to institutions was significantly higher than that generally found in cross-sectional studies.
CONCLUSIONS : The proportion of sedentary time was strongly related to metabolic risk , independent of physical activity.
CONCLUSIONS : The proposed construct of societal wisdom needs more investigation.
CONCLUSIONS : the protocol used in this work was able to identify healthy older people with low disease burden and good functionality.
CONCLUSIONS : The provisional material type , surface treatment , and artificial aging have a significant effect on bond strength.
CONCLUSIONS : The provision of informal care is stressful and results in a heightened experience of depressive symptoms.
CONCLUSIONS : The PSA level of Brazilian men undergone to check up was low.
CONCLUSIONS : The psychometric properties of the PMS in an aging adult population of long-term residents are excellent , demonstrating good reliability and responsiveness.
CONCLUSIONS : The pupil response systematically increased with decreasing speech intelligibility.
CONCLUSIONS : The quality of micro-scale environment appears to be important to mental health in older people.
CONCLUSIONS : The quantification of a single serum indicator is insufficient for determining nutritional status in the older adult.
CONCLUSIONS : The quantitative measurement of ONH topography obtained with this study provides a normative database for an Indian population with spectral OCT / SLO.
CONCLUSIONS : The questionnaire intercepted the influence of osteoporosis on the quality of life of elderly women with vertebral fractures.
CONCLUSIONS : Therapy with once-daily G-GR was as effective for treating pain associated with PHN in elderly patients as it was in younger patients.
CONCLUSIONS : The rate of invasive pneumococcal disease is highest in the very elderly , and manifestations of invasive pneumococcal disease are influenced by age.
CONCLUSIONS : The rate of UC in treated-and-released ED visits was higher in men than women , and UC rate increased with age.
CONCLUSIONS : The rates of all cholecystectomies decreased despite marked increase in laparoscopic cholecystectomies performed.
CONCLUSIONS : The RBM in these subjects was microscopically identifiable by @number@ weeks gestation.
CONCLUSIONS : There are gender-specific differences in the association of MS and CAVI.
CONCLUSIONS : There are graduated , age-related differences in the phenomenology of GAD that might contribute to challenges in the detection of late-life anxiety.
CONCLUSIONS : There are no relevant changes with healthy aging in predecisional processing.
CONCLUSIONS : There are numerous age-related changes in the metabolic profile as seen on 24-hour urine collection.
CONCLUSIONS : There are numerous anatomic age-related changes in the human eye.
CONCLUSIONS : There are significant disparities worldwide in the access to pharmaceuticals , their use , and the reimbursement of costs.
CONCLUSIONS : There are significant problems with current acute PGUs , and patient mix on existing units is an important issue.
CONCLUSIONS : The recovery of EF can extend well beyond @number@ yr.
CONCLUSIONS : The reduction in CBF was exaggerated in the upright posture in HF patients and may increase the risk for subsequent cognitive impairment.
CONCLUSIONS : There is accumulating evidence that chronic dementia caregiver stress increases their vulnerability to disease and diminishes their ability to provide optimal care.
CONCLUSIONS : There is a clear gender-associated impact on LVM with aging in humans and rats.
CONCLUSIONS : There is age-related change in bone density and geometry at the midshaft radius in middle-aged and elderly European men.
CONCLUSIONS : There is a need for validated biomarkers of aging in the context of HIV.
CONCLUSIONS : There is an exact therapeutic effect of middle segment pancreatectomy for benign tumors of the amphi-neck of the pancreas.
CONCLUSIONS : There is a non-linear association between RHR and incident HF.
CONCLUSIONS : There is a paucity of good economic data relating to pelvic organ prolapse surgery.
CONCLUSIONS : There is a positive trend in triage accuracy for older injured persons since @number@
CONCLUSIONS : There is a relationship between the presence of frailty syndrome and the intensity of the symptoms and the acceptance of AF.
CONCLUSIONS : There is a significant effect of age and sex on the QTc interval in long-QT syndrome , with a unique pattern per genotype.
CONCLUSIONS : There is a strong interest in and need for nutrition education and food skills programs for adults with developmental disabilities.
CONCLUSIONS : There is a synergistic effect of perceived problems meeting BN and the APOE epsilon4 allele on jointly influencing cognitive functioning.
CONCLUSIONS : There is a systematic , age-related decline in temporal processing starting from the fourth decade of life.
CONCLUSIONS : There is considerable scope for the improvement of prescribing practices in the elderly , and particularly those with dementia.
CONCLUSIONS : there is considerable variation in current methods of assessing grip strength which makes comparison between studies difficult.
CONCLUSIONS : There is consistent evidence from longitudinal observational studies that PA is positively associated with HA , regardless of definition and measurement.
CONCLUSIONS : There is consistent evidence that exercise and individually tailored multifactorial interventions are effective in reducing falls in community-dwelling older adults.
CONCLUSIONS : There is currently a critical shortage of primary care providers and an aging population requiring management of chronic medical conditions.
CONCLUSIONS : There is inherent color instability of nonpigmented silicone elastomer , which adds to the overall color change of silicone prostheses.
CONCLUSIONS : There is insufficient evidence available to unambiguously determine whether telemedicine consultation of leg and foot ulcers is as effective as traditional follow-up.
CONCLUSION ( S ) : There is insufficient evidence to demonstrate an unfavorable effect of paternal age on ART outcomes.
CONCLUSIONS : There is insufficient evidence to support the use of rosiglitazone in aMCI and AD patients in order to improve cognitive performance.
CONCLUSIONS : There is limited evidence regarding the effects of multiple comorbidities on treatment outcomes.
Conclusions There is little evidence of prevalence of actual and potential DIs in elderly patients with multimorbidity in outpatient settings , showing widely heterogeneous results.
CONCLUSIONS : there is no clear evidence of benefit for CGA interventions in frail older people being discharged from emergency departments or acute medical units.
CONCLUSIONS : There is potential for stem cell tourists to receive misleading or deficient information from online stem cell clinics.
CONCLUSIONS : There is scope to much further reduce Māori and especially Pacific people's risk of H. pylori infection.
CONCLUSIONS : The reliability and validity of COP measurements obtained during testing of the sensory integration processes were demonstrated using the BRU.
CONCLUSIONS : The research findings suggest that physical performance variables can be used to effectively screen elderly people at risk for frailty in the community.
CONCLUSIONS : The research provides valuable knowledge about the role of social determinants in QOL considering complex relations between different social constructs.
CONCLUSIONS : The resilience status of empty-nest elderly in communities can be divided into three categories.
CONCLUSIONS : The resin cements achieved immediate higher DC and mechanical properties when photopolymerized.
CONCLUSIONS : The response of neoadjuvant chemotherapy can be predicted.
CONCLUSIONS : The results challenge the stereotypes that present older people as neurotic , and aggressive.
CONCLUSIONS : The results confirmed that @number@ weeks of WE improves the functional fitness parameters and quality of life of older women.
CONCLUSIONS : The results demonstrated that hypothetical scenarios may help to enhance and facilitate the understanding of LST.
CONCLUSIONS : The results demonstrate that multimorbidity negatively affects role functioning , but not the mental health , of middle-aged and older individuals.
CONCLUSIONS : The results extended previous findings on the effectiveness of feedback in improving the memory performance of older adults to include memory for intentions.
CONCLUSIONS : The results from this study suggest that HIV-1 disease by itself does not significantly impair cognitive function when patients are otherwise asymptomatic.
CONCLUSIONS : The results indicate specific epigenetic alterations in elderly individuals who were subjected to childhood adversities.
CONCLUSIONS : The results indicate that both YA and MA have trouble recalling earlier pieces of information in quiet and in babble.
CONCLUSIONS : The results indicate that impaired limb proprioception is a common feature of SD.
CONCLUSIONS : The results mirror the refined indication for chemotherapy in EBC and its preferred usage as NACT in Germany.
CONCLUSIONS : The results of factor analysis suggest that the sexual perceptions of Japanese populations might differ from those of Caucasian populations.
CONCLUSIONS : The results of our study suggest an inverse , independent association between adult height and CAC.
CONCLUSIONS : The results of the discussions will further develop and strengthen the concept of healthy learning.
CONCLUSIONS : The results of the MNA in nursing home residents may differ substantially when resident interviews are compared to assessment by nursing staff.
CONCLUSIONS : The results of the present study suggest that age influences the structural and molecular properties of the tumour vasculature in ccRCC.
CONCLUSIONS : The results of the present study suggest that RSSC can be effectively collected using cigarette paper and analysed by GC-MS.
CONCLUSIONS : The results of the study suggest that the association between education and health is remarkably robust.
CONCLUSIONS : The results of the VIP survey suggest an association between animal-derived protein intake and muscle mass and strength across ages.
CONCLUSIONS : The results of this study demonstrated that old age can have an effect on the surgical outcomes of totally laparoscopic gastrectomy.
CONCLUSIONS : The results of this study demonstrated that there is a correlation between cognitive tests and pupillometry in AD patients.
CONCLUSIONS : The results of this study indicate that health behaviors , especially physical activity , are important for the health of Russia's older population.
CONCLUSIONS : The results of this study suggest noninvasive vascular testing may be inaccurate and unreliable in the majority of patients with heel pressure injuries.
CONCLUSIONS : The results of this systematic review indicate that early life exposure to DEHP is potentially associated with increased adiposity in rodents.
CONCLUSIONS : The results presented in this study increase the understanding of the forehead anatomy.
CONCLUSIONS : The results provide support for the notion that stereotype threat may lead to underperformance through somewhat different pathways in older and younger adults.
CONCLUSIONS : The results revealed that elderly patients presented significant variability , which was only partly explained by the renal function.
CONCLUSIONS : The results revealed that more sensitive assessments of change can be obtained by taking short-term fluctuation into account with measurement-burst designs.
CONCLUSIONS : The results showed that the Spanish version of the DQoL has comparable psychometric properties to the US version.
CONCLUSIONS : The results show little evidence that fractal measures of retinal vascular differences are associated with non-pathological cognitive ageing.
CONCLUSIONS : The results show that crystallins , especially αA-crystallin , aggregate irreversibly during ARNC development.
CONCLUSIONS : The results show that overuse changes in the lumbar spine of field hockey players are severe and highly correlated with years of training.
CONCLUSIONS : The results show that tube feeding does not increase patients ' nutrients absorption to improve nutritional status.
CONCLUSIONS : The results show the absence of a generalized deficit in social cognition in the elderly sample evaluated.
CONCLUSIONS : The results suggested the acquisition process of APA could be observed after @number@ trials of practice.
CONCLUSIONS : The results suggest that COL2A1 is associated with the risk of DLS in Korean population.
CONCLUSIONS : The results suggest that D2S1338-18 is associated with longevity.
CONCLUSIONS : The results suggest that occupational contexts enriched with independent planning / performance of work tasks might decrease the risk of developing dementia.
CONCLUSIONS : The results suggest that our GPJEM accurately classifies jobs according to physical demands and , although less clearly , iso-strain.
CONCLUSIONS : The results suggest that psychological approaches to chronic pain treatment may be well received by HIV-infected patients.
CONCLUSIONS : The results suggest that TCM raises the level of QOL.
CONCLUSIONS : The results suggest that the effect on SRH of mental health symptoms caused by physical illness is an increasing public health problem.
CONCLUSIONS : The results suggest that young elite athletes have longer telomeres than their inactive peers.
Conclusions : The results support our hypothesis that impaired interlimb ankle and shoulder coordination are risk factors for the development of mobility limitations.
CONCLUSIONS : The results support the viability of using unimodal verbal cueing to reduce fall risk by increasing proactive handrail use.
CONCLUSIONS : The review found that withdrawal of preventive medicines at the end of life is challenging.
CONCLUSIONS : The review highlighted the strengths and weakness of the studies ' methodological designs.
Conclusions : The revised MAL and LF-MAL are unidimensional scales and have good reliability.
CONCLUSIONS : There was a linear relationship between greater amounts of sedentary time and mortality risk after controlling for multiple potential confounders.
CONCLUSIONS : there was an improvement in teaching and assessment of learning outcomes in ageing and geriatric medicine for UK undergraduates between @number@ and @number@
CONCLUSIONS : There was an unexpected biphasic pattern of the distribution of lens power with age in this cross-sectional study.
CONCLUSIONS : There was a weak correlation between higher levels of androstenedione and healthier global , lipid , and aqueous tear film parameters.
CONCLUSIONS : There was improvement in aspects of language after four rTMS treatments , sustained a month after treatment cessation.
CONCLUSIONS : : There was no sexual difference in relation to postural balance.
CONCLUSIONS : There was no statistically significant difference between the @number@ groups for all-cause rehospitalization rates.
CONCLUSIONS : There was progressively increasing mid-range hearing loss with worsening glucose tolerance in younger individuals , suggesting dysglycaemia-associated early-onset presbycusis.
CONCLUSIONS : There were nearly half of the unilateral cleft lip nasal deformity presenting with deviated noses.
CONCLUSIONS : There were no differential effects of RENEW or TRAD as components of a MCEFRP on the primary or secondary outcomes.
CONCLUSIONS : There were no significant associations between R92H and A379V variants of PAF-AH gene and risk of PCOS in Chinese women.
CONCLUSIONS : There were significant differences in lens thickness , ACD , and ACV between nuclear and cortical age-related cataracts.
CONCLUSIONS : The rheumatology workforce in the Americas has improved between @number@ and @number@ especially in the number of pediatric rheumatologists.
CONCLUSIONS : The risk of diabetes incidence according to BMI is different among different age groups of Japanese women.
CONCLUSIONS : The risk of LSC for mortality is similar to DM.
CONCLUSIONS : The risk of trauma in the elderly population is higher.
CONCLUSIONS : The risk score diagrams can serve as a tool for young children for primary prevention of adult overweight.
CONCLUSIONS : The ROB evaluation in primary studies currently included in SRs with meta-analyses in periodontology and implant dentistry is not sufficiently comprehensive.
CONCLUSIONS : The role for non-pharmacological interventions targeting MCI is promising.
CONCLUSIONS : The rs1768208 risk polymorphism in MOBP may have prognostic value in bvFTD.
CONCLUSIONS : The savings of $ 718 to $ 840 per person is comparable to reports from other falls prevention economic evaluations.
CONCLUSIONS : The scoliosis Cobb angle , thoracic kyphosis angle , and apical vertebral translation in the GMFCS level IV-V CP patients progressed with age.
CONCLUSIONS : The screening test showed @percent@ sensitivity , @percent@ specificity , and area under the curve receiver operating characteristic of @percent@.
CONCLUSIONS : The SDD is effective in delivering Iron-induced human LDL oxidation , which is relevant to atherosclerosis , has not yet been properly investigated.
CONCLUSIONS : The SDPTG indices in children show characteristic alterations with advance of age and react to a vasodilator.
CONCLUSIONS : These are the first data regarding bone health in aging individuals who have had diabetes for @number@ or more years.
CONCLUSIONS : These core CSF biomarkers remained stable over @number@ and @number@ months in patients with early PD and HC.
CONCLUSIONS : These correlational results suggest a strong predictive effect of high musical activity throughout the life span on preserved cognitive functioning in advanced age.
CONCLUSIONS : The secular increase in height has been modest in India in spite of impressive economic growth.
CONCLUSIONS : These data cannot be explained in full by existing theories of auxiliary acquisition.
CONCLUSIONS : These data demonstrate a strong and graded inverse relationship between AHA ideal CVH metrics and prevalent CAC in adult men and women.
CONCLUSIONS : These data demonstrate that changes in LC function in the elderly are not associated with changes in systemic dendritic cell phenotype and function.
CONCLUSIONS : These data demonstrate that elderly residents in nursing homes in Sweden , Norway and Denmark are frail but heterogeneous.
CONCLUSIONS : These data demonstrate that the actin-Trx-1 complex protects Trx-1 from degradation and , thus , endothelial cells from apoptosis.
CONCLUSIONS : These data implicate large scale epigenomic change in mediating the effects of environmental damage with photo-aging.
CONCLUSIONS : These data indicate that exercise training produces fewer improvements in arterial stiffness in older hypertensive females than in older healthy females.
CONCLUSIONS : These data indicate that sKlotho levels are not affected in type @number@ diabetes patients with and without MVD.
CONCLUSIONS : These data provide evidence that older adults may be more susceptible to the effects of alcohol on certain measures of driving performance.
CONCLUSIONS : These data provide normative values that can be used in clinical practice.
CONCLUSIONS : These data provide reassurance that a 7-day accelerometer-assessment protocol provides a reproducible ( and practical ) measure of physical activity and sedentary time.
CONCLUSIONS : These data quantify the current outpatient otology workload and predict a substantial increase for many specialties , including otolaryngology.
CONCLUSIONS : These data show evidence for a positive contribution of catch-up growth in early life to adult lung function.
CONCLUSIONS : These data show macula-specific increases in mtDNA damage , heteroplasmic mutations , and diminished repair that are associated with aging and AMD severity.
CONCLUSIONS : These data suggest that cathepsin D gel could increase the SC cathepsin D content and repair the epidermal barrier in chronic photodamaged skin.
CONCLUSIONS : These data suggest that dysanaptic growth occurs during puberty and that it is not different between boys and girls.
CONCLUSIONS : These data suggest that elite comedians are at increased risk of premature death compared to their less funny counterparts.
CONCLUSIONS : These data suggest that healthy individuals exhibit a differential susceptibility to the effects of alcohol depending on their age.
CONCLUSIONS : These data suggest that PD-MCI is associated with greater sleep disturbance and nontremor features of PD.
CONCLUSIONS : These data suggest that poor glucose metabolism and diabetes are risk factors for future depression in older adults.
CONCLUSIONS : These data suggest TPN use is safe in patients aged ≥ @number@ years and advanced age alone should not preclude TPN use.
CONCLUSIONS : These data support a nutritional contribution to optimal cognitive and affective functioning in adolescents.
CONCLUSIONS : These data support conclusions that the uterus of women > or = @number@ does not inhibit embryo implantation.
CONCLUSIONS : These declines indicate that the intensity of the homeostatic or restorative processes at the beginning of sleep diminished across adolescence.
CONCLUSIONS : These findings are consistent with the notion that having an allotment garden may promote an active life-style and contribute to healthy aging.
CONCLUSIONS : These findings are of importance for two reasons.
CONCLUSIONS : These findings are relevant to policy makers and researchers involved in priority setting in low and middle income countries.
Conclusions : These findings challenge the hypothesis that deteriorating cognitive performance with long sleep duration is driven by medical comorbidities associated with aging.
CONCLUSIONS : These findings demonstrate BubR1 mRNA expression decreases along with proliferation in aged hAoSMC.
CONCLUSIONS : These findings extend prior research on the importance of social factors in aging and depression which have largely focused on mood-related outcomes.
CONCLUSIONS : These findings extend the notion of accelerated brain aging in T1D to middle-aged adults.
CONCLUSIONS : These findings have implications for training , recruiting , and retaining female pelvic surgeons.
CONCLUSIONS : These findings help in more precise targeting of future exercise interventions among older individuals.
CONCLUSIONS : These findings highlight processes that can result in changes in drinking habits and routines.
CONCLUSIONS : These findings highlight the importance of addressing non-audiological factors in order to assist older adults achieve success with hearing aids.
CONCLUSIONS : These findings highlight the importance of maintaining aerobic fitness throughout the lifespan given its capacity to improve cerebral hemodynamics in later-life.
CONCLUSIONS : These findings illustrate the negative impact of thinking about and nondiscriminately remembering past events on subsequent memory accuracy.
CONCLUSIONS : These findings indicated that reading fluency and morphological awareness should be facilitated in the Chinese instruction.
CONCLUSIONS : These findings indicate that cilostazol might provide anti-atherosclerotic effects by promoting RCT through increased ABCA1 / G1 expression in macrophages.
CONCLUSIONS : These findings offer some support for the validity of subjective cognitive complaints as markers of age related changes in memory and brain activity.
CONCLUSIONS : These findings provide evidence that inflammation is associated with T2DM and elevated depressive symptoms.
CONCLUSIONS : These findings provide evidence that LRRK2 exonic variants may contribute to susceptibility to MSA.
CONCLUSIONS : These findings provide evidence that negative symptoms are associated with lower autonomous motivation towards physical activity in inpatients with schizophrenia.
CONCLUSIONS : These findings provide insights into the molecular regulatory patterns involved in human physiology and pathophysiology.
CONCLUSIONS : These findings show that neighborhood environmental factors matter for hypertension outcomes and suggest the importance of ND for hypertension management in older adults.
CONCLUSIONS : These findings show that people who improve their cognitive performance also reduce their stereotypes score.
CONCLUSIONS : These findings suggest a possible benefit effect of n-3 PUFAs on skin aging.
CONCLUSIONS : These findings suggest individual personality traits may influence health ratings , behaviors , and decision-making among older African Americans.
CONCLUSIONS : These findings suggest needed areas of support and programs for older gay men and lesbian women.
CONCLUSIONS : These findings suggest shared genetic basis underlying the continuum from personality traits to psychopathology.
CONCLUSIONS : These findings suggest stronger impact of etiologic factors on naMCI mortality.
CONCLUSIONS : These findings suggest that age-related reductions in myonuclear domain size could be explained by the greater proportion of small fibers.
CONCLUSIONS : These findings suggest that aortic stiffness may be especially detrimental to mobility in older adults with already compromised arterial function.
Conclusions : These findings suggest that cortisol responsivity may mediate , in part , the relationship between psychological stress and cellular aging.
CONCLUSIONS : These findings suggest that different personality traits are partly subserved by specific cognitive and emotional functions in neurodegenerative disease patients.
CONCLUSIONS : These findings suggest that local volumes of inferior frontal regions are smaller in individuals with BN compared with healthy individuals.
CONCLUSIONS : These findings suggest that LRP5 A1330V polymorphism and exercise may influence BMD in Japanese male workers.
CONCLUSIONS : These findings suggest that maintaining gut microbiota , including Faecalibacterium spp.
CONCLUSIONS : These findings suggest that maintaining or initiating social participation in later life benefits the mental health of older adults.
CONCLUSIONS : These findings suggest that maintaining physical independence is a key feature of survival into extreme old age.
CONCLUSIONS : These findings suggest that non-AD , but not AD dementia , is associated with increased falls in comparison with CHIs.
CONCLUSIONS : These findings suggest that regulating disgusting behaviors and recognizing disgust in others involve two partially overlapping neural systems within the insula.
CONCLUSIONS : These findings suggest that SCE could potentially serve as a sensitive biomarker for early serous carcinogenesis within the fallopian tube.
CONCLUSIONS : These findings suggest that semantic relevance and feature type are important feature dimensions in conceptual representation and in conceptual access and retrieval.
CONCLUSIONS : These findings suggest that the plasma HSP @number@ level may be related to cognitive decline in the elderly.
CONCLUSIONS : These findings suggest that untreated type @number@ diabetes and type @number@ diabetes with complications are associated with subcortical infarctions.
CONCLUSIONS : These findings suggest that VEDS is a systemic disease with a major inflammatory component.
CONCLUSIONS : These findings support the hypothesis that the SOC ability is dynamic and mood dependent ( state effect ) .
CONCLUSIONS : These findings underscore the persistent impact of the work environment for workers of all ages.
Conclusions : These longitudinal data confirm the associations between nonandrogenic anabolic hormones and the changes in frailty status.
CONCLUSIONS : These models can assist in predicting the probability of survival and IDC for aging patients with TBI.
CONCLUSIONS : These novel findings suggest a different pattern of caudate volume abnormalities across narrow age clusters prior to puberty in boys with ADHD.
CONCLUSIONS : The sensor-based LS assessment provided new , objective insights into LS of institutionalized persons living in nursing homes.
CONCLUSIONS : These perceptions may contribute to disparities in access to KT , motivating granular studies based on the themes identified.
CONCLUSIONS : These positive effects of a short WM training , particularly for low-capacity individuals , emphasize the potential for cognitive plasticity in old-old age.
CONCLUSIONS : these potential relationships among cumulus cell gene expression , oocyte quality , and age may expand our understanding of oogenesis and embryo development.
CONCLUSIONS : These preliminary data indicate that accelerated aging at the level of leukocyte telomeres is proportional to lifetime exposure to MDD.
CONCLUSIONS : These reference values and associated attributes in youths and adults are useful in evaluating the role of FeNO in airway diseases.
CONCLUSIONS : These results allow us to differentiate the impact of functional and cognitive deficits on hospitalizations.
CONCLUSIONS : These results are comparable to previous reports using insulin resistance.
CONCLUSIONS : These results are consistent with the hypothesis that aspirin inhibits protein aggregation and the ensuing toxicity of aggregates through its acetyl-donating activity.
CONCLUSIONS : These results confirm that gastrocnemius starts to deteriorate earlier and atrophies at a faster pace than soleus.
CONCLUSIONS : These results confirm the reliability and validity of the Italian version of AADS.
CONCLUSIONS : These results demonstrated the influence of bilingualism on shaping cognitive reserve in Persian-English bilingual older adults , representing linguistic experience-dependent neuroplasticity.
CONCLUSIONS : These results demonstrate that DJS has neuroprotective effects in DA neurons against 6-OHDA-induced toxicity through anti-oxidant and apoptotic activities.
CONCLUSIONS : These results demonstrate the efficacy and safety of cement-augmented screws for the treatment of patients with low bone mineral density.
CONCLUSIONS : These results demonstrate the feasibility of routinely measuring neuromagnetic brain function in healthy , awake pre-school-aged children.
CONCLUSIONS : These results highlight the advantages of analysing fine structure data of the 2f2-f1 DPOAE to track subtle cochlear changes in response to aging.
CONCLUSIONS : These results highlight the role of neighborhood environments in buffering cognitive decline among older adults aging in place.
CONCLUSIONS : These results indicate that aging human meibomian glands show decreased meibocyte differentiation and cell cycling that is associated with the development of MGD.
CONCLUSIONS : These results indicate that hearing aid ownership and ALD usage remains low in the older population.
CONCLUSIONS : these results indicate that unmarried individuals have shorter telomeres.
CONCLUSIONS : These results provide critically important information about water temperature , apparatus , and child age on CPT pain responding.
CONCLUSIONS : These results provide evidence of significant hip proprioception declines with age.
CONCLUSIONS : These results provide in vivo evidence of RCAN1-regulated vascular branching which may play a role in the patterning of morphologically different vasculature.
CONCLUSIONS : These results show that there is a correlation between depressive symptoms and weight status.
CONCLUSIONS : These results show that the SLC25A32 gene polymorphism could be a risk factor for lower folate concentration and future fracture.
CONCLUSIONS : These results suggest an inverse association between the T allele of rs117385980 and longevity.
CONCLUSIONS : These results suggest high fibrinogen level is associated with increased risk of PD among men over @number@ years.
CONCLUSIONS : These results suggest that aberrant Plk methylation is correlated with the development of HCC in mice.
CONCLUSIONS : These results suggest that ageing and mild AD may reduce the ability to identify odours and judge situations based on odours.
CONCLUSIONS : These results suggest that AH lipid peroxidation markers and antioxidants may significantly depend on the cataract maturity stage.
CONCLUSIONS : These results suggest that although OA is an age-related disease , aging is not the crucial factor in the pathogenesis of OA.
CONCLUSIONS : These results suggest that a preventive home visit program may reduce monthly health care costs , primarily by reducing hospitalization costs.
CONCLUSIONS : These results suggest that beta blocker use might be associated with longer survival in patients with stage IV CRC.
CONCLUSIONS : These results suggest that CSF CD8 T cells in AHI expanding in the CNS are functional and directed against HIV antigens.
CONCLUSIONS : These results suggest that depletion contributes to executive lapses in older adulthood.
CONCLUSIONS : These results suggest that dietary supplementation of HMB , glutamine and arginine may favorably affect vascular endothelial function in older adults.
CONCLUSIONS : These results suggest that Klotho has a potential therapeutic effect on attenuating endothelial dysfunction and ameliorating atherosclerosis.
CONCLUSIONS : These results suggest that maternal HIV infection or exposure to ART has minimal effect on infant leukocyte TL , a reassuring finding.
CONCLUSIONS : These results suggest that performance feedback serves as a reward in both younger and older adults.
CONCLUSIONS : These results suggest that polymorphisms in XRCC1 codon @number@ may be associated with the development of age-related cataract in Han Chinese.
CONCLUSIONS : These results suggest that RECQL1 is a prognostic factor for EOC and that RECQL1 contributes to potential malignancy by inhibiting apoptosis.
CONCLUSIONS : These results suggest that serum cholesterol and cognitive function are associated in older age via the lifelong stable trait of intelligence.
CONCLUSIONS : These results suggest that some middle-aged women with little or no pure-tone hearing loss experience listening difficulty in complex environments.
CONCLUSIONS : These results suggest that the considered mixture improved intestinal calcium absorption and bone metabolism in post-menopausal women.
CONCLUSIONS : These results suggest that the human M1 shows age-dependent reduction of cortical plasticity.
CONCLUSIONS : These results suggest that the skeletal morphology of the face changes with age.
CONCLUSIONS : These results suggest that tinnitus is a common symptom in this cohort and may be associated with some modifiable risk factors.
CONCLUSIONS : These results suggest utilization of absolute cutpoints may underestimate daily relative intensity levels of physical activity in older adults with T2DM.
CONCLUSIONS : These results support an involvement of the ADM gene in the modulation of peripheral vascular tone.
CONCLUSIONS : These results support a role for sIL-2Rα in atherosclerosis and provide evidence for multiple-associated single-nucleotide polymorphisms at chromosome 10p15-14.
CONCLUSIONS : These results support a specific association between orbitofrontal areas and behavioral management as compared with dorsolateral areas and EF.
CONCLUSIONS : These results support the beneficial effect of habitual physical activity in spatial memory.
CONCLUSIONS : These results support the clinical use of both RIA and cFT as measures of FT.
CONCLUSIONS : These results support the suggestion that , whereas integrative mechanisms are not affected by age , suppressive mechanisms are.
CONCLUSIONS : These RT results highlight the interdependence between bottom-up sensory and top-down semantic processing.
CONCLUSIONS : The serum phenylalanine concentration is associated with telomere length and , therefore , potentially with the aging process.
CONCLUSIONS : The serum RNase-L levels were inversely associated with MetS , unfavorable metabolic profiles , and age.
CONCLUSIONS : The SHARE Frailty Instrument has sufficient construct and predictive validity , and is readily and freely accessible via web calculators.
CONCLUSIONS : The simple and reliable CNST shows good sensitivity and specificity and significantly predicts adverse outcomes.
CONCLUSIONS : The sleep EEG during childhood shows high within-subject stability and may be a marker for intellectual ability.
CONCLUSIONS : The slowing and weakness of older muscle was associated with superior fatigue resistance during sustained isometric contractions.
CONCLUSIONS : The SmartLipo @number@ nm is a safe and effective platform to combine with facelifts.
CONCLUSIONS : The social capital scores in these women were low.
CONCLUSIONS : The societal costs of dementia are very high.
CONCLUSIONS : The socioeconomic impact of hip fractures will be high in the near future.
CONCLUSIONS : The storage times and mechanical load cycling did not affect the microtensile bond strength of self-adhesives and RelyX ARC resin cements.
CONCLUSIONS : The strength of the association between obesity and back pain may vary by country.
CONCLUSIONS : The studied cements behaved acceptably according to deltaE , but they became more opaque after aging.
CONCLUSIONS : The study design proved to be feasible for a senior population.
CONCLUSIONS : The study gives some indication that a moderately high level of serum DHA might prevent cognitive decline among community-dwelling elderly Japanese individuals.
CONCLUSIONS : The study identified a series of training priorities for staff assisting people ageing with an intellectual disability.
CONCLUSIONS : The study indicated that allometric scaling could be applied to predict the CL of coagulation factors in children from adults with accuracy.
CONCLUSIONS : The study indicates that diet is important for aural health in aging.
CONCLUSIONS : The study provides novel information on the delirium experience in patients with dementia.
CONCLUSIONS : The study provides the first evidence that in vivo platelet activation is significantly and directly associated with NOx2 activity.
CONCLUSIONS : The study results do not suggest an association between donor diabetes and PK outcome.
CONCLUSIONS : The study results provide an important basis for studies aiming at the assessment of met and unmet needs in the elderly population.
CONCLUSIONS : The study revealed a high prevalence of PIM use among the community-based aged population.
CONCLUSIONS : The study revealed contemporary Australian perspectives on nursing scholarship.
CONCLUSIONS : The study suggested that an estimate of median age at natural menopause were @number@ years in Jiangsu women.
CONCLUSIONS : The study suggest that a cardiac rehabilitation program in postmyocardial infarction improves exercise capacity , QoL and autonomic modulation.
CONCLUSIONS : The subjects who consumed at least @number@ g / day of fruits and vegetables generally showed a better nutritional status.
CONCLUSIONS : The substitution of VA for CA may increase the FRS category.
CONCLUSIONS : The supplementation with Silybin-vitamin E -phospholipids complex increased work ability and reduced depression and anxiety in patients treated with Peg-IFN and RBV.
Conclusions : the support needs of care home entrants in England appear to be increasing over time.
CONCLUSIONS : The supraorbital keyhole approach via a forehead wrinkle incision was safe and effective.
CONCLUSIONS : The surgical choice should be made case by case ( custom-made ) , not based on age only.
CONCLUSIONS : The surgical risk calculator could be useful for predicting mortality and reoperation in elderly patients with hip fracture.
CONCLUSIONS : The survival benefits of weight gain after ART initiation are dependent on starting BMI.
CONCLUSIONS : The Sweet @number@ is simple , quick to administer , and will be available open access.
CONCLUSIONS : The SWFL scale shows partial measurement invariance across older adults from Chile and Ecuador.
CONCLUSIONS : The systematic review and meta-analysis revealed that malnutrition and physical frailty in community-dwelling older adults are related , but not interchangeable geriatric syndromes.
CONCLUSIONS : The technical quality of root canal filling performed by dental practitioners in a Turkish subpopulation was consistent with a high prevalence of AP.
CONCLUSIONS : The technique of AO retinal imaging allows a direct measurement of the retinal vessel wall and lumen diameter with good intra-observer variability.
CONCLUSIONS : The technique PESF has affected the metabolic processes and the speed of wound healing ulcer in patients with T2DM.
CONCLUSIONS : The Theory of Finding Home was generated from the data.
CONCLUSIONS : The three-step Luria test distinguished NC and persons with MCI from FTD and AD , but did not distinguish FTD from AD subjects.
CONCLUSIONS : The total prevalence of sarcopenia was @percent@ increasing with age reaching @percent@ in people of @number@ or more years of age.
CONCLUSIONS : The treadmill test is limited in almost @number@ % of elderly patients with PAD and non-PAD.
CONCLUSIONS : The treatment of proximal humeral fractures with a polyaxial locking plate is reliable using both approaches.
CONCLUSIONS : The trends of the pediatrician workforce increase generally kept pace with urbanization , but were not associated with the original pediatrician workforce supply.
CONCLUSIONS : The true incidence of cardiovascular outcomes post-liver transplant remains unknown in large part due to lack of consensus regarding outcome definition.
CONCLUSIONS : The TSH-free T₄ relationship is not inverse log-linear but can be described by @number@ overlapping negative sigmoid curves.
CONCLUSIONS : The Tsimane demonstrate higher levels of cardiovascular fitness than industrialized populations , but levels similar to other subsistence populations.
CONCLUSIONS : The uAm / uCr ratio correlated with sAm , and may be an alternative to sAm for prediction of hyperamylasemia.
CONCLUSIONS : The uHear application is inaccurate in assessing hearing thresholds for screening in the elderly.
CONCLUSIONS : The uniform heating RF treatment is safe and effective for non-invasive body sculpting.
CONCLUSIONS : The UPSA-M performed just as well as the standard-of-practice version.
CONCLUSIONS : The uptake of influenza vaccination among diabetic patients in the present study was below desirable levels.
CONCLUSIONS : The use of anti-dementia drugs was common in both care settings.
CONCLUSIONS : The use of DAPs in older patients with stable CVD was associated with an increased number of hospital days but not with mortality.
CONCLUSIONS : The use of hypoglycaemic drugs was associated with poor health outcomes in nursing home residents.
Conclusions. : The use of inappropriate medications is a major problem among older adults in Bogota.
CONCLUSIONS : The use of INTERCheck ( ® ) was associated with a significant reduction in PIMs and new-onset potentially severe DDIs.
CONCLUSIONS : The use of long-term care services varies by living area.
CONCLUSIONS : The use of medications with anticholinergic properties is common among older persons cognitively health as well as with cognitive impairment.
CONCLUSIONS : the use of multiple endocrine parameters showed a high prevalence of biochemical hyperandrogenism in patients with PCOS.
CONCLUSIONS : The use of NSAIDs , as for SAIDs , is associated with an increased risk of chronic AF.
CONCLUSIONS : The use of PFO / D4-GFP allowed a robust and direct detection of EC in aged murine BrM.
CONCLUSIONS : the use of SBs is not associated with a lower fall risk compared with LBs.
CONCLUSIONS : The use of the MBI-HHS as an instrument for measuring burnout among ID workers has its attraction but also its limitations.
CONCLUSIONS : The use of VMFO is common among community-dwelling older people and it has significantly increased over ten years.
CONCLUSIONS : The various ethnic groups examined differed in their attitude and behaviour towards shipboard sun exposure.
CONCLUSIONS : The vitamin D group maintained muscle mass , and the SMI increased in patients with low muscle mass.
CONCLUSIONS : The VMS-tool plus age ( VMS + ) offers an efficient instrument to identify frail hospitalised older adults at risk for adverse outcome.
CONCLUSIONS : The VU + group exhibited poorer physical performance than the VU- group.
CONCLUSIONS : The weight of the evidence supports using genetic testing to guide selection of ocular vitamin use.
CONCLUSIONS : The WHO Child Growth Standards are a better tool for assessing the nutritional status of Indonesian children than the NCHS / WHO reference.
CONCLUSIONS : Thiol repair systems were damaged in all types of cataracts.
CONCLUSIONS : This American family presented with progressive bulbar neuropathy due to a gelsolin mutation not found in Finland.
CONCLUSIONS : This approach enabled the development of clinical tools more rapidly than with a traditional systematic review.
CONCLUSIONS : This assessment exercise indicates that nursing care in medical units faces high workloads.
CONCLUSIONS This case raises awareness of B. cepacia as a potential opportunistic pathogen in CIED infection.
CONCLUSIONS : This chart abstraction method can retrospectively diagnose delirium in hospitalised patients with good accuracy.
CONCLUSIONS : This cohort study showed that 6-year CS Organismal aging is a multifactorial process characterized by the onset of degenerative conditions and cancer.
CONCLUSIONS : This comprehensive review revealed that old age is a real risk factor for IgAN progression to ESRD.
CONCLUSIONS : This cross-sectional study might provide the possibility of OA initiation and progression.
CONCLUSIONS : This cross-sectional study reveals a positive association between breakfast consumption frequency and muscle strength in apparently healthy adults.
CONCLUSIONS : This delirium risk modification project was associated with patient outcomes and reduced costs.
CONCLUSIONS : This first analysis of the relationship between phytoestrogens and frailty revealed an inverse association between urinary O-DMA levels and frailty in women.
CONCLUSIONS : This home-based case management intervention was not able to prevent falls or injurious falls.
CONCLUSIONS : This hypothesis explains phylogenetic differences related to lifespan and longevity , and body-size differences between species and within the same species.
CONCLUSIONS : This interdisciplinary intervention program may improve health outcomes of elders with hip fracture.
CONCLUSIONS : This inverse relationship between muscle mass and quality implies that sarcopenic individuals have better muscle quality than nonsarcopenic individuals.
CONCLUSIONS : This investigation was the first epidemiological study of dynamics of laryngeal cancer by component analysis in the population of Kazakhstan.
CONCLUSIONS : This in vivo study demonstrates that honeybush produces significant anti-wrinkle effects and is therefore of interest in anti-aging skin care products.
CONCLUSIONS : This is an observational study , so causal conclusions cannot be drawn.
CONCLUSIONS : This is the first comprehensive study of the subjective hair changes in postmenopausal women.
CONCLUSIONS : This is the first human study to demonstrate that insulin resistance may contribute to amyloid deposition in brain regions affected by AD.
CONCLUSIONS : This is the first prospective study investigating whether APOE-e4 moderates the association between exercise and depressive symptoms.
CONCLUSIONS This is the first reported case of neuro-myelomatosis of the brachial plexus.
CONCLUSIONS : This is the first report of an increasing trend of insulin-related unintentional therapeutic errors in the ambulatory setting.
CONCLUSIONS : This is the first study investigating the efficacy of a ToM training and its transfer effect on metacognition in older adults.
CONCLUSIONS : This is the first study on a primate model of human HD based on longitudinal clinical measurements.
CONCLUSIONS : This is the first study revealing residual effects of Zp on driving performance in ageing drivers which are similar to that of Zc.
CONCLUSIONS : This is the first study that estimated heritability of LTL and also its age-dependent attrition.
CONCLUSIONS : This is the first study to compare safety and efficacy of different doses of ABO administered to the entire face simultaneously.
CONCLUSIONS : This is the first study to define the limits of normal upper FD and FICDs in any population group.
CONCLUSIONS : This is the first study to describe mitochondrial dysfunction and oxidative stress involvement in KS.
CONCLUSIONS : This is the first study to directly examine mitochondrial function in skeletal muscle from an AD-relevant transgenic murine model.
CONCLUSIONS : This is the first study to our knowledge to estimate the effect of country-specific health expenditures on life expectancies of men and women.
CONCLUSIONS : This is the first study to report mortality data and expected survival curves for major abdominal surgery in the octogenarian population.
CONCLUSIONS : This is the first systematic retrospective analysis of a patient group to define the coexistence of sodium channelopathy and genetic PKP2 variations.
CONCLUSIONS : This longitudinal MRI study found clinically silent brain white matter hyperintensities to be predominantly progressive in nature.
CONCLUSIONS : This longitudinal study showed that visceral obesity was associated with future loss of skeletal muscle mass in Korean adults.
Conclusions : This longitudinal study suggests that transition from full-time work to statutory retirement is associated with an increase in sleep duration.
CONCLUSIONS : This menopause model demonstrates that nighttime vasomotor symptoms correlate with increased sleep fragmentation.
CONCLUSIONS : This meta-analysis demonstrates that mir-196a2 SNP influences the susceptibility of lung cancer.
CONCLUSIONS : This meta-analysis does not support the idea that rs1800795 genotype is associated with increased risk of knee OA.
CONCLUSIONS : This meta-analysis supports orthogeriatric collaboration to improve mortality after hip repair.
CONCLUSIONS : This meta-analysis supports the idea that RASSF1A gene hypermethylation is associated with cigarette smoking-induced lung cancer.
CONCLUSIONS : This meta-synthesis presents the perspectives of home-dwelling old people on health-promoting self-care experiences.
CONCLUSIONS : This model can guide the development of innovative approaches to improving pain management in LTC settings.
CONCLUSIONS : This modified assay generates reliable measurements as judged by correlation with data derived by the telomeric restriction fragment Southern blot-based method.
CONCLUSIONS : This needs assessment reinforces findings from previous studies and addresses the added dimension of examining this in an urban , lower socioeconomic population.
CONCLUSIONS : This new anthropometric survey indicates that inter- and intra-gender interocular facial measurement stability is a characteristic of presbyopic subjects.
CONCLUSIONS : This new single-frequency BIA-derived equation was precise , accurate and free of bias.
CONCLUSIONS : This nonpharmacologic intervention reduced depressive symptoms in both African-American subjects with and without financial strain.
CONCLUSIONS : This observational study highlights striking gender- and age-related differences in plasma lipid profiles.
CONCLUSIONS : This overview of paradigm shifts in ophthalmology suggests that the future will see significant improvements in ophthalmic diagnostics.
CONCLUSIONS : This paper illustrates considerable variations of disability and its relationship with age.
CONCLUSIONS : This paper provides detailed information on the clinical , metabolic and genetic profiles of all HHH syndrome patients published to date.
CONCLUSIONS : This patient fulfilled all clinical criteria of ReGS that is believed to be caused by neuropathy of the left pudendal nerve.
CONCLUSIONS : This PD model displays consistent and clinically relevant motor and sleep phenotypes.
CONCLUSIONS : This pilot study demonstrates improvement in rigidity and balance following EA.
CONCLUSIONS : This pilot study , the first to investigate IGF-1 and delirium in critically ill patients , found no association between IGF-1 and delirium.
CONCLUSIONS : This population-based study showed that radiation oncology workload increased at faster rates than the population or incidence of cancer.
CONCLUSIONS : This pragmatic comparative trial showed high rates of adverse events and cost-related non-adherence with AChEIs.
CONCLUSIONS : This preliminary study suggested that nonacidic silane-based primers with HEMA addition might be an alternative to for use as adhesion promoting primers.
CONCLUSIONS : This preliminary study suggests that PATH is well accepted and efficacious in depressed elders with major depression , cognitive impairment , and disability.
CONCLUSIONS : This prospective observational study shows significant beneficial effects in patients suffering from evaporative DED , using F6H8 in all the relevant parameters tested.
CONCLUSIONS : This prospective study provides evidence that childhood obesity , and how it develops , is associated with standing sagittal postural alignment in adolescence.
CONCLUSIONS : This RCT suggests that the seated stepping exercise is more effective at improving ambulatory function in DT conditions than in ST conditions.
CONCLUSIONS : This report expands on previous phenotypical descriptions attempting to further develop and refine this possible diagnostic entity.
CONCLUSIONS : This research confirms the role of SS of distress in fueling disability and perceived ill health among older adults who are chronically ill.
CONCLUSIONS : This research focused on smoking as a lifestyle factor that may alter telomere length and subsequently telomerase kinetics in the skin.
CONCLUSIONS : This review found no effects of non-equipment based rehabilitation interventions on emotional and functional status , self-efficacy , and social participation.
CONCLUSIONS : This review highlights the lack of consensus regarding a definition of cognitive reserve.
CONCLUSIONS : This review indicates a robust interplay between lipids , inflammation , and calcific AS.
CONCLUSIONS : This scoping review identified a range of needs of stroke survivors as perceived by their caregivers.
CONCLUSIONS : This study addressed the feasibility of training multiple instructors of varying experience to administer this theatre-arts intervention.
CONCLUSIONS : This study adds to the accumulating evidence that psychological trauma and chronic stress are associated with accelerated telomere attrition.
CONCLUSIONS : This study adds to the literature in two important ways.
CONCLUSIONS : This study advances the understanding about the role of therapeutic self-care ability in supporting the safety of home care clients.
CONCLUSIONS : This study based on provincial data points to tangible areas for preventative assessment by frontline home care professionals.
CONCLUSIONS : This study confirmed a significant decline in VEMP amplitude and increase in VEMP thresholds in healthy older persons.
CONCLUSIONS : This study confirmed that both chronological and functional age were associated with a decrease in work outcomes.
CONCLUSIONS : This study confirms that hospitalized sepsis is frequent in Norway and a major contributor to hospital fatalities in a European setting.
CONCLUSIONS : This study confirms the high prevalence of eye diseases in the elderly.
CONCLUSIONS : This study contributes to the literature on the relationship between volunteering and health for older women.
CONCLUSIONS : This study could inform clinicians about the selection of suitable rehabilitation approaches to help patients achieve clinically meaningful improvement in upper extremity function.
CONCLUSIONS : This study defines the CCT in a large population of patients undergoing refractive surgery.
CONCLUSIONS : This study delineated that SA significantly increased the long-term mortality in geriatric participants.
CONCLUSIONS : This study demonstrated a transition pattern in older adult depression within a person-centered approach.
CONCLUSIONS : This study demonstrated that in older persons the presence of serum PTH levels within the upper normal range is highly related to CVD.
CONCLUSIONS : This study demonstrated the technical feasibility of visualizing the MP in real time by CV-assisted pCLE ( UMIN-CTR number , UMIN000015056 ) .
CONCLUSIONS : This study demonstrates a higher rPWV in elderly people than in young people.
CONCLUSIONS : This study demonstrates dynamic alterations in RNA with age at numerous genomic levels , indicating changes in the regulation of transcriptional networks.
CONCLUSIONS : This study demonstrates that alterations in structural and functional connectivity develop before the first symptoms of FTD arise.
CONCLUSIONS : This study demonstrates that diastolic function is important for normal hemodynamic adjustment during the metaboreflex and to avoid excessive vasoconstriction.
CONCLUSIONS : This study demonstrates that regular physical activity may play a protective role in the oxidation of LDL in older adults.
CONCLUSIONS : This study demonstrates that VMMSE is a valid instrument in clinical and research screening and monitoring of subjects affected by cognitive disorders.
CONCLUSIONS : This study demonstrates the coexistence of multiple cardiovascular diseases is an independent predictor of the 30-day mortality of hospitalized patients with CHF.
CONCLUSIONS : This study demonstrates the complex associations between the various stakeholders involved in this caregiving arrangement.
CONCLUSIONS : This study described different motivators and barriers for PTs to organize PA in LTCFs.
CONCLUSIONS : This study describes the most extensive proteomic analysis of muscle ageing in humans , and identified @number@ new potential biomarkers.
CONCLUSIONS : This study describes the temporal relationship between arsenic concentrations ≥ 10μg / L in drinking water and CKD.
CONCLUSIONS : This study determined the types of adenoviruses causing keratoconjunctivitis at one center in Saudi Arabia.
CONCLUSIONS : This study developed a novel antibacterial glass-ionomer cement.
CONCLUSIONS : This study discusses the major risk factors for BC in Puerto Rico ( PR ) .
CONCLUSIONS : This study documents marked seasonal variation in serum sclerostin levels.
CONCLUSIONS : This study documents significant associations between CAC and cerebral SVDs.
CONCLUSIONS : This study does not support a protective effect of bilingualism on age-related cognitive decline or the development of dementia.
CONCLUSIONS : This study establishes that certain lifestyle factors influence LTL dynamics.
CONCLUSIONS : This study examined the changes in total and segmental body composition with aging and COPD severity.
CONCLUSIONS : This study extended our understanding of how the perception of life constraints and health problems influence the elderly's daily experience.
CONCLUSIONS : This study found a U-shaped association between BMI and levels of depressive symptoms among adults in Korea overall and also within each gender.
CONCLUSIONS : This study found that PPM use remains highly prevalent among long-stay Medicare NH residents.
Conclusions : This study goes beyond previous research by examining the association between filial discrepancy domains and depressive symptoms.
CONCLUSIONS : This study has shown the new grading criteria of wrinkles on the knee.
CONCLUSIONS : This study highlights the important role community centers play in the lives of Chinese older adults.
CONCLUSIONS : This study highlights the large number of insured adults with undiagnosed type @number@ diabetes by insurance type and state.
CONCLUSIONS : This study histologically demonstrated that type I and III collagen increased significantly in the dermis after mRF treatment.
CONCLUSIONS : This study identified lifetime socioeconomic patterning of fat and lean mass in early old age.
CONCLUSIONS : This study identified nine factors influencing the QoL of older people living alone in Mainland China.
CONCLUSIONS : This study identifies a novel role of sFRP-1 in age-related cardiac deterioration and fibrosis.
CONCLUSIONS : This study identifies the impact of medical tourism on CRC screening and characteristics of KA patients who report engaging in medical tourism.
CONCLUSIONS : This study identifies the need to fully understand the management realities of front-line caregivers of critically ill children in community hospital settings.
CONCLUSIONS : this study improves the evidence of weather factors as a determinant for walking and cycling in older adults.
CONCLUSIONS : This study indicated a high incidence of cortical opacities and lower incidence of nuclear opacities compared with Caucasians.
CONCLUSIONS : This study indicated that levels of education , happiness , and stress could influence the perception of herbal medicine consumption.
CONCLUSIONS : This study indicates that stressed individual have markedly lower levels of DHEA-S.
CONCLUSIONS : This study intends to capture large data from various medical institutions with a new accounting system.
CONCLUSIONS : This study is the first prospective trial demonstrating efficacy and safety of cream PUVA in MF patients.
CONCLUSIONS : This study is the first that investigates the WM FD spanning adulthood , treating age both as a continuous and categorical variable.
CONCLUSIONS : this study is the first to compare differences in LE in frailty categories across European countries.
CONCLUSIONS : This study is the first to demonstrate training-related benefits to gross motor performance stemming from cognitive dual-task training.
CONCLUSIONS : This study is the first to develop and apply medication appropriateness indicators for patients with advanced dementia in the UK setting.
CONCLUSIONS : This study is the first to investigate CRP variability in a nonindustrialized , high infectious disease environment.
CONCLUSIONS : This study is the first to report the repeatability of LT measures using the Visante AS-OCT in the non-cyclopleged eye.
CONCLUSIONS This study is the first to show that sarcopenia is associated with higher postoperative costs and rates of blood transfusion following thoracolumbar spine surgery.
CONCLUSIONS : This study lends support to hypothesized association between tooth loss and severe cognitive impairment.
CONCLUSIONS : This study points to an association between maternal excess weight in pregnancy and offspring BMI change from adolescence to adulthood.
CONCLUSIONS : This study points to possibly overprescribing of anxiolytics among women and low detection and treatment of depression among the elderly in general.
Conclusions : This study points to the importance of social activity engagement and positive support from family and friends in increasing the sense of community.
CONCLUSIONS : This study presented as its main findings that most seniors showed no nutritional risk , with high prevalence of overweight.
CONCLUSIONS : This study provides additional evidence of a possible etiological importance of this toxin in some cases of the human disease ET.
CONCLUSIONS : This study provides comprehensive estimates of PAD in the inpatient and outpatient settings where the majority of PAD burden was found.
CONCLUSIONS : This study provides data on levels of heavy metals in a group of elderly people.
CONCLUSIONS : This study provides evidence , on balance , supporting the integration of an ACP in the DEM assessing elderly patients.
Conclusions : This study provides evidence that different types of social support were associated with variations in the utilization of cancer screenings.
CONCLUSIONS : This study provides evidence that DSI could play a significant role in the development of behavioral symptoms in nursing home residents.
CONCLUSIONS : This study provides evidence that the prevalence of polypharmacy in the elderly in Emilia-Romagna is substantial.
Conclusions : This study provides firm evidence to support clinically observed associations between UI and back problems.
CONCLUSIONS : This study provides information on the implication of the experience of delirium on caregivers and staff.
CONCLUSIONS : This study provides initial support for the USE-PAP for measuring PAP device usability.
CONCLUSIONS : This study provides initial validation of 3D strain analysis from RT3DE images and reference values of normal 3D LV strain and torsion.
CONCLUSIONS : This study provides insights that a high pro-inflammatory status in sedentary obese elderly women might impair muscle strength and negatively affect fat-free mass.
CONCLUSIONS : This study provides new evidence supporting a causal link between Chagas disease and stroke.
CONCLUSIONS : This study provides normative data on sleep macrostructure , microstructure , and respiration in adults following AASM standards.
CONCLUSIONS : This study provides population-based reference data on LBM in men , and these data may be used clinically for the diagnosis of sarcopenia.
CONCLUSIONS : This study provides preliminary evidence that lonafarnib therapy may improve neurologic status of children with HGPS.
CONCLUSIONS : This study provides preliminary findings that this therapeutic video game targeting cognitive control deficits may be an efficacious LLD intervention.
CONCLUSIONS : This study provides the first comparative analysis between the reversible and the structural disulfides.
CONCLUSIONS : This study provides the first data on normal entheseal sonoanatomy and vascularisation in children.
CONCLUSIONS : This study provides the first evidence of an alteration of mitochondrial biogenesis with early life stress and with anxiety and substance use disorders.
CONCLUSIONS : This study replicated most common findings in patients with schizophrenia with regard to thalamic and frontal GM deficits.
CONCLUSIONS : This study reported two models : the first model describes what older adults with hearing aids believe constitutes patient-centred audiological rehabilitation.
CONCLUSIONS : This study reports the population-based RVO incidence in Korea.
CONCLUSIONS : This study revealed that ESRD influenced HDL subfractions.
CONCLUSIONS : This study revealed that increased fructose concentration and decreased antioxidant status might have a role in the myocardial infarction.
CONCLUSIONS : This study revealed that the prevalence of IPUs in patients with peptic ulcers in Japan is @percent@ , much higher than previously reported.
CONCLUSIONS : This study sheds new light on the prevalence of DAP use and concomitant use of DAPs and AChEIs among NH residents with dementia.
CONCLUSIONS : This study showed significant improvements in patient-assessed mobility , softness , and appearance.
CONCLUSIONS : This study showed that comedication use in the aging HIV / HCV population is frequent and diverse.
CONCLUSIONS : This study shows increased prevalence of MS and unfavorable effects of testosterone replacement in young patients with CHH.
CONCLUSIONS : This study shows that haplogroups have a significant influence on serum levels of MMP-3 and MMP-13.
CONCLUSIONS : This study shows that patients using automated drug dispensing have a high number of DRPs.
CONCLUSIONS : This study shows that polypharmacy and PIMs remain highly prevalent among nursing home residents.
CONCLUSIONS : This study shows that the association between obesity and cognitive decline was confounded by the effect of age on rate of decline.
CONCLUSIONS : This study suggests detrimental associations between protein intake and bone health.
CONCLUSIONS : This study suggests substantial inter-physician variation in follow-up habits after screening colonoscopy.
CONCLUSIONS : This study suggests that adherence to the Mediterranean diet is associated with lower odds of sarcopenia among the Iranian elderly.
CONCLUSIONS : This study suggests that both tHcy and holoTC may be involved in the development of AD.
CONCLUSIONS : This study suggests that common genetic variation in WRN is associated with increased risk of ischemic stroke in the general population.
CONCLUSIONS : This study suggests that performance on the CDT was impaired not only by disease but also by aging.
CONCLUSIONS : This study supports the finding of high under-recognition rates of delirium among hospitalized older adults in ICU.
CONCLUSIONS : This study underscores the importance of examining the contribution of psychological and behavioral factors when addressing racial differences in pain processing.
CONCLUSIONS : This study underscores the role of clinical and electrodiagnostic data when interpreting lumbosacral neuroimaging , particularly in older patients.
CONCLUSIONS : This suggests that greater protein intake benefits women especially those with lower Ca intakes.
CONCLUSIONS : This survey indicates that in third-level headache centers in Italy OBT-A is used in good compliance with current recommendations.
CONCLUSIONS : This systematic review comes from a highly selected but small source of data.
CONCLUSIONS : This technique is a viable method for reducing the earlobe with minimally visible scars.
CONCLUSIONS : This trial investigates the effectiveness and cost-effectiveness of TAP within an Australian population.
CONCLUSIONS : This work demonstrates the capacity of budget impact analysis to enhance the implementation of complex interventions.
CONCLUSIONS : This work provides reference hippocampal labels for the training and certification of automated segmentation algorithms.
CONCLUSIONS : This work shows for the first time that a Lipocalin rescues neurons from pathogenic SCA1 degeneration by optimizing clearance of aggregation-prone proteins.
CONCLUSIONS : Though midlife hypertension was more common in men , it was only associated with dementia risk in women.
CONCLUSIONS : Though they may exhibit a default asymmetry under various walking conditions , persons with PD can adapt and store new walking patterns.
CONCLUSIONS : Three common themes emerged from the narratives.
CONCLUSIONS : Three-dimensional speckle-tracking echocardiography can be an effective noninvasive method for assessing 3D LV twist.
CONCLUSIONS : Three disability trajectories were identified from hospital admission until one-year follow-up in acutely hospitalized older patients after hip fracture.
CONCLUSIONS : Three modifiable behaviors-smoking , drinking alcohol , and physical activity-were associated with changes in vision.
CONCLUSIONS : Threshold testing and joint position matching methods examine different physiological aspects of proprioceptive function.
CONCLUSIONS : Through identifying the expectations of prospective residents , retirement village providers may better tailor facilities to the needs of their target demographic.
CONCLUSIONS : Through these surveys , we described the cross-sectional profiles of sIBM in Japan.
CONCLUSIONS : Thus , QUASAR reliability for regional perfusion is high within gray matter , but uncertain within white matter.
CONCLUSIONS : Thyroid disease must be excluded in patients affected by hyperparathyroidism.
CONCLUSIONS : Time-of-day appears to affect cognitive performance of older patients after they undergo TIA and minor stroke.
CONCLUSIONS : Time spent sitting was independently associated with increased risk of diabetes diagnosis among obese women-a population already at high risk of the disease.
CONCLUSIONS : Tissue loss and altered morphology were found in elderly schizophrenia patients.
CONCLUSIONS : TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa.
CONCLUSIONS : TLR4 signaling promotes ingestion of sugar and fat by a mechanism involving increased preference for such obesogenic foods.
CONCLUSIONS : TLR pathway engagement in pDCs is necessary but not sufficient for a successful neonatal Th1 outcome.
CONCLUSIONS : TM cells are responsive to ABCB1 inhibitors and activators.
CONCLUSIONS : To alleviate the public and private burden of osteoporosis related fractures , assessment of risk and reduction of individual risk is critical.
CONCLUSIONS : Today , surgeons must be equipped to attend the geriatric patient's needs.
CONCLUSIONS : to fully understand residents ' QoL , detailed interview-based instruments , administered by an experienced interviewer are needed.
CONCLUSIONS : Together , these findings demonstrate that the pattern of fluency performance looks generally the same regardless of how performance is measured.
CONCLUSIONS : Together , these findings indicate that rs-SMR power is a specific and easy-to-measure predictor of later ISC learning performance.
Conclusions : Together , these results uncover cellular senescence as a player during the formation of microaneurysms in old-age human retinas.
CONCLUSIONS : To our knowledge , this is the first time that TT + VR has been used for gait training in PD.
CONCLUSIONS : To our knowledge this is the first work to evaluate the effect of COS on moles.
CONCLUSIONS : To our knowledge , this is the largest report of astroblastoma patients described in the literature.
CONCLUSIONS : To perform accurate prehension , elderly people have an earlier peak tangential velocity point than young adults.
CONCLUSIONS : To properly represent multimorbidity , using dichotomous measures should be used with caution.
CONCLUSIONS : To reduce avoidable blindness , un-operated cataract should be addressed.
CONCLUSIONS : To sum up , our data suggested that the FAS gene A-670G polymorphism may not be associated with AD.
CONCLUSIONS : Total INR monitoring costs per patient were estimated at minimally €138.
CONCLUSIONS : Total laryngectomy determines olfactory and gustatory impairments that should be taken into account in clinical practice.
CONCLUSIONS : Total PA declines with age but significant decline does not occur until ages @number@ to @number@
CONCLUSIONS : Total protein intake was significantly inversely associated with frailty in elderly Japanese women.
CONCLUSION : ST + placebo was associated with decreased MIF levels suggesting decreased inflammatory activity.
CONCLUSIONS : Training providers to discuss certain treatment-specifics with patients may improve their ability to perceive patient-agreement regarding treatment and may directly improve patient-adherence.
CONCLUSIONS : Transcutaneous lower eyelid blepharoplasty combined with orbitomalar suspension is a powerful technique that can be performed concomitantly with facial rejuvenative procedures.
CONCLUSION : Strategies which prevent deterioration in clinical measures or delay dependence should result in total cost savings.
CONCLUSIONS : Trauma , regardless of Depression , is associated with worse verbal learning and memory , but not recognition performance.
CONCLUSIONS : Traumatic brain injury has persistent symptomatic effects and significantly affects ambulation and spatial orientation years after the event.
CONCLUSIONS : TREAT appears to have reduced avoidable emergency geriatric admissions , and to have shortened LOS for all emergency geriatric admissions.
CONCLUSIONS : Treatment of patients with stroke is a large national investment.
CONCLUSIONS : Treatment of the periocular region with CaHa injections is a safe and effective treatment with high patient satisfaction and low complication rate.
CONCLUSIONS : Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.
CONCLUSIONS : Treatment with GesTIO protocol allows a safe and effective treatment even in very old and vulnerable inpatients with a faster management insulin therapy.
CONCLUSIONS : Treg cells are associated with immunosenescence.
CONCLUSIONS : Trends from this study indicate that functional retraining programmes could be effective in preventing functional decline.
CONCLUSION : Strengthening the supervision on high incidence area and high-risk industry is the key point to reduce the incidence of acute occupational poisoning accident.
CONCLUSION : Strength ratios did not correlate with MTH ratios.
CONCLUSIONS : Trial participants are younger than KTRs in the United States and many trials exclude older patients.
CONCLUSIONS : Triolein reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes.
CONCLUSIONS : Triple antiplatelet therapy might be a better antiplatelet regimen than dual antiplatelet therapy for patients with ST-segment elevation myocardial infarction.
CONCLUSION : Stroke survivors who return to driving have no differences in their driving confidence to their aged-matched non-stroke driving peers.
CONCLUSION : Stronger relation of HT and OSA severity in younger patients should encourage us to screen OSA in these patients at very young age.
CONCLUSIONS : Trospium chloride XR does not increase the likelihood of a TEAE compared with placebo.
CONCLUSIONS : Trust in physician is commonly endorsed among U.S. Chinese older adults.
CONCLUSIONS : Trypsin-1 and trypsin-2 appear to have a function in the degradation of vitreous type II collagen.
CONCLUSIONS : TSH exhibited a stronger effect on the TC and LDL-C level in moderately old subjects than in younger subjects.
CONCLUSIONS : TT levels are independently associated with aortic stiffening.
CONCLUSION : Students were presented with an opportunity to actively engage with independently living elderly patients.
CONCLUSION : Studied indices in this study significantly differ from available guidelines and these differences must be considered when making diagnostic or therapeutic decisions.
CONCLUSION : Studies on the causal relationship between the two syndromes are clearly necessary in the future.
CONCLUSION : Study findings suggest that the ostomy population demonstrates successful aging similar to the US general population.
CONCLUSION : Study results from National Long Term Care Survey data provide evidence supporting the potential for exercise to lower the risk of dementia.
CONCLUSIONS : TUG and UGS have similar predictive ability in relation to incident disability in basic ADL and IADL.
CONCLUSIONS : Turbo spectroscopic imaging is a good method for analyzing normal changes in the pons metabolites during growth , maturation , and aging.
CONCLUSIONS : T₁-weighted @number@.0T MRI and T₂-weighted @number@.0T MRI can well demonstrate the laminar organization.
CONCLUSIONS : Twenty-three risk-adjusted , HC-QIs are described.
CONCLUSIONS : Twist-untwist mechanics may evolve with advancing age.
CONCLUSIONS : Two years of modest CR without a structured exercise component did not appear to compromise aerobic capacity in healthy nonobese adults.
CONCLUSIONS : Type @number@ DM is associated with dysregulation of glycemic variability over multiple scales of time.
CONCLUSION : Subcutaneous facial fat fluctuates with aging , increasing in the upper face and promoting ptosis through basal compartmental expansion.
CONCLUSION : Subjective age is a salient marker of individuals ' at risk for poor sleep quality , beyond chronological age.
CONCLUSION : subjects experienced significant improvements in perceived appearance , attractiveness , tiredness , age , and satisfaction versus placebo.
CONCLUSION : Subjects treated for forehead wrinkles showed significant clinical improvement with high subject satisfaction and no serious adverse events.
CONCLUSION : Subjects with 25 ( OH ) D serum levels ≥ @number@ ng / ml were less frequently prefrail or frail.
CONCLUSION : Subjects with h- and w-sarcopenia differ significantly in terms of obesity indicators.
CONCLUSION : Subperiosteal vertical midface lift resuspends and redrapes the facial network that originates at the level of the orbital rim.
CONCLUSION : Substantial heterogeneity exists in rates of cognitive decline among older Mexican Americans.
CONCLUSION : Substantial heterogeneity in lower extremity function trajectories exists in the African American Health cohort , after appropriately treating mortality as informative censoring.
CONCLUSION : Substantive differences exist between scales in their content validity , feasibility , and ability to predict all-cause mortality.
CONCLUSION : Successful adaptation to spousal loss is primarily associated with high scores in psychological resilience and extraversion and low scores in neuroticism.
CONCLUSION : Suggestions for improving retention of older adults in self-administered treatments are discussed.
CONCLUSIONS : UI was highly prevalent , especially in bladder , endometrial / uterine , and prostate cancer survivors.
CONCLUSION : Sulfonylureas are associated with increased risk of hip fracture in elderly men and women with type @number@ diabetes.
CONCLUSIONS : Underestimation of the remaining life expectancy of older people is prevalent in health care professionals and may lead to patients being managed inappropriately.
CONCLUSIONS : Under our experimental conditions , WJ-MSCs enhanced skin wound healing in an in vivo mouse model.
CONCLUSIONS : Understanding surgical anatomy including facial layers , spaces , and retaining ligaments is crucial for stable application of facelift techniques in Asian patients.
CONCLUSIONS : Understanding the different generational groups may allow nursing leaders and managers to consider what drives , motivates or hinders nurses from different generations.
CONCLUSIONS : Under static conditions , LLIs lead to significant changes of the pelvic position and spinal posture.
CONCLUSIONS : Under-treatment is significantly reduced after CGA.
CONCLUSIONS : Undiagnosed cognitive impairment in T2DM-patients is associated with a reduced health status and more depressive symptoms.
CONCLUSIONS : Undiagnosed HT is prevalent at an alarming rate among adult males in the Central Province of Sri Lanka.
CONCLUSIONS : Unlike Ad36 , E4orf1 does not appear to stimulate inflammatory response.
CONCLUSIONS : Unlike other areas of the body where there is descent of soft tissues , there is paradoxical elevation of eyebrows with aging.
CONCLUSIONS : Unrelieved pain can have a detrimental effect on older adults ; conversely , overmedicating can lead to an increased risk of adverse events.
CONCLUSION : Supplementation with functional food bioactives can temporarily reverse the age-associated decline in renal function and serum total protein.
CONCLUSIONS : Uptake of online intervention varies according to age , gender and cancer type.
CONCLUSION : Surface and subsurface reflection characteristics show age-dependent changes.
CONCLUSION : Surgeries in elderly patients were effective and safe.
CONCLUSION : Surgical risk in patients over @number@ years of age was higher than patients less than the age of @number@ years.
CONCLUSIONS : Urinary incontinence and cognitive impairment in elderly patients were associated to an increase in caregiver burden.
CONCLUSIONS : Urinary incontinence is a previously unidentified risk factor for falls among elderly dementia patients.
CONCLUSIONS : Urologic cancer burden has increased globally amid population growth and aging.
CONCLUSION : Surrogates can both impede and facilitate engagement in ACP , and they can hold different perceptions from patients regarding this engagement.
CONCLUSION : Survival in older adults differs in length and quality depending on specific conditions.
Conclusion Survivors who had multimodal treatment had higher cytokines and comorbidities , suggestive of accelerated aging.
CONCLUSIONS : Use of clinically significant anticholinergic medications was associated with a @percent@ increase in risk of mortality among elderly nursing home residents with depression.
CONCLUSIONS : Use of combination codes provided more accurate representation of how foods were consumed by populations.
CONCLUSIONS : Use of guideline-recommended cardiac drugs is associated with reduced mortality in the elderly Medicare HF population.
CONCLUSIONS : Use of implants and spinal fusion is always associated with a risk of complications and is frequently independent of the surgeon.
CONCLUSIONS : Use of ultrasonic baths can be a successful means for improving denture hygiene among older people in long-term care with and without dementia.
CONCLUSIONS : Using both Medicare and MDS data to identify LTC stays will lead to more accurate attribution of CMS nursing home quality indicators.
CONCLUSIONS : Using LCA , we identified eight distinct cognitive subtypes in a large sample of patients with AD dementia.
CONCLUSIONS : Using noninvasive corneal indentation pulse measurement revealed , for the first time , an ocular pulse dicrotism.
CONCLUSIONS : Using opportunistic CT scanning , this study demonstrates the relative frequency of osteoporosis in acute fractures of the cervical spine.
CONCLUSIONS : Vaccination would substantially reduce the burden of infant GBS disease in South Africa and would be very cost-effective by WHO guidelines.
CONCLUSIONS : Vancomycin MICs may vary dependent on testing methodologies and local MRSA epidemiology.
CONCLUSIONS : Variants in CFH , ABCA1 , and ARMS2 genes are related to the presence and progression of drusen in early AMD.
CONCLUSIONS : Various anatomic factors were related to periorbital changes in Asian patients.
CONCLUSIONS : Vascular anatomy of axilla is complex and variable.
CONCLUSIONS : Vascular dementia and Alzheimer's disease , but not mixed dementia , are more prevalent in patients with atrial fibrillation.
CONCLUSIONS : Vascular risk factors are associated with reduced white matter integrity among older adults , which subsequently predicted faster cognitive decline.
CONCLUSIONS : Ventilatory response during and after PWM is higher in older individuals than in young individuals.
CONCLUSIONS : Vertebral instability is a factor causing symptoms of osteoporotic vertebral fractures with intravertebral cleft.
CONCLUSIONS : Very few patients reported counseling for sexual activity after AMI.
CONCLUSIONS : Veterans with HIV have higher rates of Medicare and / or Medicaid enrollment , but lower odds of non-VA hospitalization.
CONCLUSIONS : VHR in the oldest-old carried significantly higher 30-day overall morbidity , serious morbidity and mortality , compared with younger patients.
CONCLUSIONS : Vibration is a safe and effective method of achieving anesthesia during facial dermal filler injections.
CONCLUSIONS : Video monitoring offers high potential to support conventional care in memory care facilities.
CONCLUSIONS : Vietnam-era Veterans with PTSD have diminished functioning and increased disability.
CONCLUSIONS : Visual impairment can lead to slowing of cognitive performance in older adults ; these effects are greater than those observed in younger participants.
CONCLUSIONS : Visually impaired elderly persons participate in society , but they participate less than their peers.
CONCLUSIONS : Vitamin B-12 supplementation improved arterial function in vegetarians with subnormal vitamin B-12 levels , proposing a novel strategy for atherosclerosis prevention.
CONCLUSIONS : Vitamin D deficiency , delirium and male gender were significant risk factors for a longer LOS in the studied sample of older inpatients.
CONCLUSIONS : Vitamin D deficiency was highly prevalent and associated with increased mortality among the elderly in Swedish nursing homes.
CONCLUSIONS : Vitamin D insufficiency was associated with increased WMA volume in the studied sample of older adults.
CONCLUSIONS : Vitamin D status was not associated with early AMD in this cohort sample.
CONCLUSIONS : VN patients show poor postural performance , which is affected by age , residual vestibular function , and disease duration.
CONCLUSIONS : Voluma is easy to use , sculpt , and massage.
Conclusions : volume of objectively measured PA among older people was positively associated with the physical performance measured with a validated fitness test battery.
CONCLUSIONS : Volume restoration in the midface and perioral or lip region can be effectively achieved using a variety of dermal fillers.
CONCLUSIONS : VR-based applications can potentially offer more versatile , comprehensive , and safer assessments of function.
CONCLUSIONS : VRC measures are sufficiently consistent to be suitable for comparing muscle membrane function both within subjects and between groups.
CONCLUSIONS : VSMC from aged patients showed a higher degree of cellular senescence and it was associated to a lower TGF-β1 secretion and signaling.
CONCLUSIONS : VVI can be used to effectively and noninvasively assess LV twist-displacement loop with change in age and provide important information for LV function.
CONCLUSIONS : Waiting for long-term care from the hospital is a stressful and uncertain time for family carers.
CONCLUSIONS : walking , sedentary and transitory behaviours are distinct from each other , and together explain daily function.
CONCLUSIONS : WBVAT treatment may increase BMD in senior people , particularly those with OP and women.
CONCLUSIONS : WC and AC gap detection ability changes across the lifespan.
CONCLUSIONS : WCE size is related to aging , not to CVD risk.
CONCLUSION : SWE allows quantitative assessment of the stiffness of the plantar fascia , which decreases with aging and in patients with plantar fasciitis.
CONCLUSIONS : We analyzed the prevalence of different astigmatisms within a European population.
CONCLUSIONS : We anticipate that our results will provide new thoughts and methods for the study of IVD disease.
CONCLUSIONS : We believe that ASEAN has significant potential to become a force for better health in the region.
CONCLUSIONS : We believe that this study helps to provide insight into the role of psychosocial factors in late-life depression.
CONCLUSIONS : We clarified basic trends of age- and gender-related amino acid concentrations in serum.
CONCLUSIONS : We concluded against extension of this pilot study.
CONCLUSIONS : We concluded that DHJST and its active component L. chuanxiong are able to promote osteogenic activity and decrease hMSCs senescence as cells age.
CONCLUSIONS : We conclude that donor age does not affect the characteristics , proliferation , and osteogenic differentiation potential of hTMSCs.
CONCLUSIONS : We conclude that executive function is the primary cognitive domain affected by WMH burden.
CONCLUSIONS : We conclude that home-based exercise programs are beneficial for individuals at risk for diabetes.
CONCLUSIONS : We conclude that intakes of most micronutrients were near recommendation levels , unusual within the complementary feeding experience in scientific literature.
CONCLUSIONS : We conclude that our findings reflect neurophysiologic differences between young and middle-aged adults for IPD processing in concurrent sound segregation.
CONCLUSIONS : We conclude that RT can be incorporated to potentially offset the metabolic complications of BR.
CONCLUSIONS : We conclude that swallowing accelerometry and swallowing sounds provide different information about deglutition despite utilizing similar transduction methods.
CONCLUSIONS : We conclude that there are gender differences related to better QOL in this sample.
CONCLUSIONS : We confirmed age-related declines in otolith function , and observed a protective effect of black race on oVEMP latency and amplitude.
CONCLUSIONS : We confirm the association of a PARK10 haplotype with the risk of developing idiopathic PD.
CONCLUSIONS : We demonstrate a good correlation between weight and MSCD in a large group of children.
CONCLUSIONS : We demonstrated an association between SSO events and ER visits for GI illness using a case-crossover study design.
CONCLUSIONS : We demonstrated that aerobic exercise training significantly decreased plasma ADMA concentrations with increase in carotid arterial compliance in postmenopausal women.
CONCLUSIONS : We demonstrated that interactive educational interventions are effective in the elderly TBI population.
CONCLUSIONS : We demonstrate genetic overlap between AD , C-reactive protein , and plasma lipids.
CONCLUSIONS : We demonstrate that women with a history of PE have significantly lower AMH levels than women with normotensive pregnancies.
CONCLUSIONS : We describe a novel bioimaging approach with implications for the evaluation of pathology in a broader range of biological situations.
CONCLUSIONS : We described echocardiographic measures of structure and function in a group of healthy octogenarians.
CONCLUSIONS : We describe the first reported case of pulmonary mucormycosis with pulmonary eosinophilia caused by Cunninghamella bertholletiae , which resulted in disseminated mucormycosis.
CONCLUSIONS : We determined that the sebum production has a positive correlation with the distance away from the injection point.
CONCLUSIONS : We developed a scoring system , based on easy-to-collect risk factors , to identify individuals most likely to have advanced neoplasms.
CONCLUSIONS : We developed a simple model that predicts risk for in-hospital adverse events among patients undergoing ICD placement.
CONCLUSIONS : We did not find a dose-response relationship between area-level income inequality and mortality.
CONCLUSIONS : We elucidated the antifibrotic mode of action of the sGC that increases cGMP levels , blocks non-canonical TGFβ signalling and inhibits experimental fibrosis.
CONCLUSIONS : We established scientific and reasonable RIs of blood cell analysis for the healthy elderly in our region.
CONCLUSIONS : We find concordance among many aspects of cardiovascular pathology in both HGPS and geriatric patients.
CONCLUSIONS : We find that aging is associated with bidirectional changes in gene expression.
CONCLUSIONS : We find that certain ageing-associated immune-system impairments may be mediated via changes in DNA methylation.
CONCLUSIONS : We found a high prevalence of unrecognized COPD in elderly patients with CHF and central obesity.
CONCLUSIONS : We found a positive association between handgrip strength and circulating CD34-positive cells in hypertensive men.
CONCLUSIONS : We found a significantly earlier presence of positive symptoms on the NPI-Q in cognitively normal patients who subsequently developed CDR @number@
CONCLUSIONS : We found considerable heterogeneity in symptom profiles among older adults with an index episode of major depression.
CONCLUSIONS : We found cross-sectional evidence that SES disparity in lung function increases with age , especially for men.
CONCLUSIONS : We found high rates of unoperated cataract in older people in north and south India.
CONCLUSIONS : We found no evidence of any relationship between specific mitochondrial haplogroups and depressive symptoms.
CONCLUSIONS : We found no evidence to support the expectation that baby boomers will age more or less healthily than previous cohorts did.
CONCLUSIONS : We found only a limited number of studies exhibiting high quality evidence and were being included in the meta-analyses.
CONCLUSIONS : We found sarcopenia incidence increased with age , and women were more likely to have sarcopenia.
CONCLUSIONS : We found several significant changes in the older individuals in regulatory elements of the adaptive immune system that occur particularly after immune activation.
CONCLUSIONS : We found substantial variations in MSK mortality and its trends between countries , regions and also between sex and age groups.
CONCLUSIONS : We found suggestive evidence of association between a single SNP located in the @number@'UTR of WDR77 with calcaneal ultrasound parameters.
Conclusions : We found supporting evidence for two out of three hypothesized resilience indicators to be related to frailty levels in older adults.
CONCLUSIONS : We found that about one fifth of newly diagnosed MM fails to collect an adequate number of PBSC.
CONCLUSIONS : We found that among long-lived Chinese subjects , higher levels of SUA may be associated with higher BMI.
CONCLUSIONS : We found that determinants of sexual activity in older people are numerous and varied , and change over time.
CONCLUSIONS : We found that lower cerebral vasomotor reactivity is associated with an increased risk of death.
CONCLUSIONS : We found that @number@ valid and reliable measures of mobility interacted with sex to predict changes in well-being over time.
CONCLUSIONS : We found that QOL appears to be significantly impaired in cancer survivors compared to controls , even when remote from initial cancer diagnosis.
CONCLUSIONS : We found that the association between obesity and lowered SHBG is greater than the association of ageing with increased SHBG.
CONCLUSIONS : We found the risk of CD decreases in overweight and obese elderly.
CONCLUSIONS : We found weak evidence of an association between daily ultrafine particles and mortality.
CONCLUSIONS : We have developed a centralized database that is very well suited for the management of data for ageing research.
CONCLUSIONS : We have developed a PHS for quantifying individual differences in age-specific genetic risk for AD.
CONCLUSIONS : We have developed MCI risk scores using variables easily assessable in the clinical setting and that may be useful in routine patient care.
CONCLUSIONS : We have established a new LAR protocol that permits quantification of novel LAR metrics that are translatable between mice and humans.
CONCLUSIONS : We have further demonstrated the association of PPY and IgM with NAB , despite technical differences between studies.
CONCLUSIONS : We have identified a decrease in reactive persulfide and polysulfide species in the lungs of patients with COPD.
CONCLUSIONS : We have identified a new spastic ataxia syndrome caused by a genomic duplication , which we have denoted as spinocerebellar ataxia type @number@
CONCLUSIONS : We have identified @number@ plasma proteins strongly associated with disease severity and disease progression.
CONCLUSIONS : We have objectified the health state of living with upper arm deformity requiring brachioplasty.
CONCLUSIONS : We have proposed , tentatively , a panel of outcome measures which could be deployed in community-based , lifestyle intervention studies.
CONCLUSIONS : We have shown that blastomere volume is directly proportional to the number of mtDNA copies.
CONCLUSIONS : We have successfully overcome many system-level barriers in implementing a collaborative care program for dementia and depression in primary care.
CONCLUSIONS : We have very limited evidence that ceramics perform better than composite material for inlays in the short term.
CONCLUSIONS : We identified a cluster of single nucleotide polymorphisms at the NLGN1 locus showing significant association with BP variability.
CONCLUSIONS : We identified age-associated DNA methylation and expression changes in human liver that are partly reflected by epigenetic alterations in blood.
CONCLUSIONS : We identified four memory trajectories.
CONCLUSIONS : We identified @number@ common single-nucleotide polymorphism and @number@ gene region that were significantly associated with AF.
CONCLUSIONS : We identified @number@ loci associated with circulating tPA levels , the PLAT region , STXBP5 , and STX2.
CONCLUSIONS : We identified three metabolite biomarkers , which in combination increase the predictive value of the Framingham risk score.
CONCLUSIONS : Weight gain between 20-40 years of age could be an important factor in the aetiology of diabetes.
CONCLUSIONS : Weight loss due to social reasons was not associated with mortality suggesting that not all unintentional weight loss is harmful.
CONCLUSIONS : Weight loss influenced several miRNAs , some of which were negatively correlated with predicted targets.
CONCLUSIONS : We observed a constant proportion of falls clinic patients taking BZs or Z drugs between @number@ and @number@
CONCLUSIONS : We observed an association between increased vascular cell senescence with PCAD in a sample of young patients from India.
CONCLUSIONS : We observed an increased MS prevalence in the province of Genoa , compared to @number@
Conclusions : We observed financial exploitation associated with brain differences in regions involved in socioemotional functioning.
CONCLUSIONS : we present an accurate non-linear regression model for EGP as a function of age.
CONCLUSIONS : We present evidence that age modifies associations between CD4 count and plasma albumin and haemoglobin levels.
CONCLUSIONS : We propose in this article to review the clinical symptoms of negative hallucinations in the elderly and the way to manage them.
CONCLUSIONS : We propose that maternal aging significantly reduces the oocyte pool , superovulation efficiency and developmental potential and increases the oocyte aneuploidy rate.
CONCLUSIONS : We prospectively demonstrated the relevance of our anti-falling intervention at home and of the use of posturography for clinical follow-up.
CONCLUSIONS : We provide a method to determine upper bounds and accurate approximate p-values of the rank product statistic.
CONCLUSIONS : We provide potential evidence for the involvement of a multifunctional proinflammatory cytokine gene ( TNF ) in the frailty phenotype.
CONCLUSIONS : We recommend integrating outreach services and lifestyle counseling within programs for care of the elderly.
CONCLUSIONS : We report an extensive and systematic en face analysis of LF / MLF-AF in AMD eyes.
CONCLUSIONS : We report a statistically significant difference between subjects falling in the 10th percentile extremes of MPOD and rod-mediated but not cone-mediated sensitivity recovery.
CONCLUSIONS : We report the successful launch of a unique Web-based instrument referred to as the Sequential Questions and Answers test.
CONCLUSIONS : We reviewed plans and improved the fall-prevention strategy for mentally ill residents of long-term care facilities.
CONCLUSIONS : We revised several proteins and microRNAs recently implicated in cardiac aging and proposed for the first time modules as signatures.
CONCLUSIONS : We show a greater update bias in healthy older age.
CONCLUSIONS : We showed that NAION onset at age > 50 years had a greater risk of second eye involvement.
CONCLUSIONS : We show for the first time that CCR2 expression is associated with lower MMSE scores in an older human population.
CONCLUSIONS : We show gradual lesion expansion many years after stroke , beyond that expected by normal aging and after controlling for other variables.
CONCLUSIONS : We show that DNA methylation at MCHR1 is allele-specific , age-dependent , BMI-associated and affects transcription.
CONCLUSIONS : We show that the OP group had reduced TAS , whereas the elevated TPx was different from that in the NOP group.
CONCLUSIONS : We suggest that EE of MSL is a potent predictor for falls among healthy elderly adults.
CONCLUSIONS : We uncovered a new locus associated with LTL in the general population.
CONCLUSIONS : We use semantic technologies to discover candidate aging genes whose effects on lifespan are not yet well understood.
CONCLUSIONS : \ "What is the latest news on TV or papers ? \ " was highly effective in identifying AD and MCI.
CONCLUSIONS : When compared to adult men , developing children typically have higher estimates of kinematic features related to normalized displacement and its derivatives.
CONCLUSIONS : When making decisions about body weight management , women's needs were \ "getting information \ " and \ "getting support. \ "
CONCLUSIONS : While age and day @number@ FSH levels were predictive of outcome , we found no association between insLQ and patient response to COH.
CONCLUSIONS : While education level was found to be related to post-stroke VCI in previous research , the effects were small.
CONCLUSIONS : While in adults DP symptoms are frequently associated with mental disorders , in adolescents they could be considered as a quasi-physiological phenomenon.
CONCLUSIONS : While lifetime abstainers had significantly better lifetime mental health histories than nonbingers , ex-drinkers had worse past-year mental health status.
CONCLUSIONS : While the prevalence of malnutrition was low , RM was high in the elderly population in China.
CONCLUSIONS : While younger athletes ' performance has stagnated , Masters athletes improved their athletic performance significantly and progressively over the years.
CONCLUSIONS : Whole blood viscosity at low shear rate is a novel indicator for SCI regardless of classical cardiovascular risk factors.
CONCLUSIONS : WHOQOL-AGE has shown good psychometric properties in Finland , Poland , and Spain.
CONCLUSIONS : With advancing age , the CH and CRF in adult Chinese decreased.
CONCLUSIONS : With aging , there appears to be a pattern of differential fat pad alteration.
CONCLUSIONS : With an aging population , the high prevalence of shoulder pain may have considerable impact on public health.
CONCLUSIONS : With extended follow-up , ESSs ' risk for late mortality and SNs does not plateau.
CONCLUSIONS : With good to substantial agreement , we found the development of a photographic forearm sun damage assessment scale highly feasible.
CONCLUSIONS : With increasing age , bulb diameter , tortuosity , and bifurcation angle increases in carotid arteries.
CONCLUSIONS : Within the prevalent population , the percentage of elderly persons will not increase meaningfully.
CONCLUSIONS : With newly developed signal features , this study proposed and tested a single-channel EEG-based SWS detection method.
CONCLUSIONS : With the use of objective biomarkers , long-chain n-3 FAs and ALA were not associated with a higher incidence of diabetes.
CONCLUSIONS : WMHs are usefully divided into dWMH and pWMH regions because they demonstrate differential effects.
CONCLUSIONS : Women show better verbal memory than men in aMCI despite similar levels of brain hypometabolism.
CONCLUSIONS : Women's reactions to their vaginal atrophy varied according to personality.
CONCLUSIONS : Women's views and attitudes towards symptoms are variable and age is a significant factor.
CONCLUSIONS : Women with major mobility issues who developed breast cancer confronted numerous physical barriers during the course of their breast cancer diagnosis and treatment.
CONCLUSIONS : Women with mother or sister affected by breast cancer are diagnosed and die at earlier ages than do women without family history.
CONCLUSIONS : Women with SUI and MUI symptoms present different morphological defects at rest.
CONCLUSIONS : Women with the longest leukocyte telomere length underwent menopause @number@ years later than those with the shortest leukocyte telomere length.
Conclusions Workers with poor health are more likely to leave the labor force than workers with good health.
CONCLUSIONS : Working conditions have a great influence in the idea of inability to perform the same type of work at @number@
CONCLUSIONS : Working might be protective from a decline in BADL only for men , but not for women.
CONCLUSIONS : Work-related CE is specifically associated with PTSD.
CONCLUSIONS : WWT performance was a significant predictor of falls.
CONCLUSION : Sympathetic nerve fibers are present in the adventitia of the internal thoracic artery.
CONCLUSION : Symptom assessments and geriatric assessments are useful tools in everyday practice.
CONCLUSION : Symptoms encompassed within the Agitation factor have distinct neurobiologic underpinnings.
CONCLUSIONS : Young , asymptomatic , HIV-infected women , demonstrate increased noncalcified coronary plaque and increased immune activation , particularly monocyte activation.
CONCLUSIONS : Younger age at type @number@ diabetes diagnosis is significantly associated with a poor diabetes-related QoL.
CONCLUSIONS : Younger and older IMN patients had similar renal outcomes.
CONCLUSIONS : Younger onset T2DM patients have worse glycemic and lipid control , and higher prevalence of retinopathy compared to older onset T2DM patients.
CONCLUSIONS : Youth with severe disabilities and youth without disabilities had similar odds of and durations to insurance regain.
Conclusion : systolic BP < 130 mm Hg increased the likelihood of incident depression in a cohort of community-dwelling older adults.
CONCLUSIONS : Y-TZP materials showed the highest biaxial flexure strength.
CONCLUSIONS : ZNF704 may be a potential candidate gene for studies of the genetic underpinnings of longevity.
CONCLUSIONS : β-blocker use is associated with a lower risk of developing cognitive impairment in elderly Japanese American men.
CONCLUSIONS : Δ Leptin and ΔFM were strong contributors to changes in REE.
CONCLUSION : T1 lesion load is the most significant MRI correlate of auditory ERPs in MS patients.
CONCLUSION : T1ρ demonstrates changes related to the processes of normal aging.
CONCLUSION : T2 spatial variation is different between skeletally immature and mature patellar cartilage.
CONCLUSION : Taken together , isonitramine inhibited α-glucosidase activity and PEPCK expression , while increased insulin expression , resulting in attenuating the postprandial hyperglycemia.
CONCLUSION : Taken together , our data demonstrated that miR-495 induced senescence of MSCs may be involved in the pathogenesis of PE.
CONCLUSION : Taken together , this study provides initial normative and validation data for the SOPT , but further validation studies are needed.
CONCLUSION : Targeting human mINDY may have therapeutic potential in obese patients with nonalcoholic fatty liver disease.
CONCLUSION : T. arjuna bark extract appears as an innovative active ingredient that exerts versatile antiaging properties in vitro and in vivo.
Conclusion : Task modifications in walking may help community-dwelling older people to postpone life-space mobility decline.
CONCLUSION : T-DM1 is effective and well-tolerated even in intensively pre-treated patients.
CONCLUSION : Telomeres rather than telomerase are involved in cellular senescence.
CONCLUSION : Telomeric shortening may be attenuated by ω-3 PUFA supplementation , requiring further investigation in larger samples.
CONCLUSION : Temporal semantic knowledge is altered in AD.
CONCLUSION : Testicular volume and metabolism appear to be significantly affected by advancing age at different rates during the different stages of lifespan.
Conclusion : Testosterone replacement attenuated the age-related increase in QTcF duration in men.
CONCLUSION : TFL can be used at high density and in simultaneous combination with other targeted laser modalities to achieve rejuvenation of the aging chest.
CONCLUSION : Thai dance can improve physical performance in recently aged ( elderly ) female adults.
CONCLUSION : The 1940nm thulium laser is safe , well tolerated , and results in reduced downtime compared to traditional resurfacing.
CONCLUSION : The 30-day and 5-year mortality in patients who survived rAAA was equal between the treatment options of eEVAR and OPEN.
CONCLUSION : The 3DR technique was useful and may allow a better understanding of the pathogenetic changes in the skin surface in aging skin.
CONCLUSION : The 6CIT's psychometric properties in a real-world setting suggest that the test is not suited as a routine screening instrument.
CONCLUSION : The ABC stands as a viable alternative to consider when assessing falls efficacy among dynamic older adults.
CONCLUSION : The accuracy and precision of stature estimation by fibula and ulna bone length is comparable to that by knee height.
CONCLUSION : The addition of lidocaine substantially reduces the pain of LGP-HA injection without altering safety.
CONCLUSION : The ' adiposity rebound ' is characterised by increasing lean mass index , coupled with cessation of the decline in fat mass index.
CONCLUSION : The adjusted number of vulnerable asylum seekers was higher in districts with medium and highest deprivation compared with districts with lowest deprivation.
CONCLUSION : The advanced paternal age was associated with elevated risk for schizophrenia in offspring among a Han Chinese population.
CONCLUSION : The advantages of this NIMNRF treatment for skin tightening are its long-lasting high efficacy as shown through 3-D volumetric assessments.
CONCLUSION : The aged population has a more negative attitude towards performing BLS.
CONCLUSION : The age-related changes in CAT and ROTEM variables among adults are not linear.
CONCLUSION : The age-related patterns of somatosensory perception from this study refine decision making about performance.
CONCLUSION : The aging process and mortality are associated with low vitamin D levels.
CONCLUSION : The AIRS can be considered a photonumeric scale that accurately describes volume loss in the infraorbital region.
CONCLUSION : The alcohol consumption patterns were quite different between China and Norway.
CONCLUSION : The anti-aging effects of mild-warming moxibustion may be due to increased Bcl-2 and PKC expression in peripheral blood in aged people.
CONCLUSION : The anticoagulant activity from abdominal aortic aneurysms is preserved.
CONCLUSION : The applied statistical approach appears suitable to identify unusual performance in screening colonoscopy databases.
CONCLUSION : The areas of the brain involved in perceiving changes in facial emotion have not matured by @number@ years of age.
CONCLUSION : The assessment of GFR by the Gates method must be carefully considered in the early stages of CKD , especially in younger patients.
CONCLUSION : The associated indicators differed between the sexes.
CONCLUSION : The association between age and depression has to take cohort membership into account.
CONCLUSION : The associations between CHADS ( @number@ ) covariates and increased bleeding risk were weak , with the exception of age.
CONCLUSION : The associations between homocysteine levels and medication use appear to be fairly modest.
CONCLUSION : The authors ' findings suggest a considerable age-dependent variation with regard to anxiety and depressive disorders in adults with a cancer history.
CONCLUSION : The authors report for the first time that an elevated leukocyte count is independently associated with moderate to severe WMLs.
CONCLUSION : The average inbreeding coefficient of this population is significantly higher than that of the general Caucasian populations in North America.
CONCLUSION : the average temporal resolution threshold for women was @number@.81ms.
CONCLUSION : The baseline S.AGES study results exhibit a well-balanced therapeutic management of chronic pain by GPs for ambulatory elderly patients.
CONCLUSION : The benefit of cartilage treatments in patients with increasing age but without any sign of osteoarthritis was higher than previously reported in literature.
CONCLUSION : The benefits of exercise for reducing risk of chronic disease , including CVD , are well known.
CONCLUSION : The bilateral hippocampal MK / MD values may be more sensitive than volumes in the diagnosis of aMCI and AD patients.
CONCLUSION : The brief RFS contains a second-order factorial structure.
CONCLUSION : The burden of AD reflects the structure of Italian welfare.
CONCLUSION : The Cantonese Chinese MoCA is a consistent and reliable instrument.
CONCLUSION : The CD14bright / CD56 + monocyte subset is expanded in aging individuals as well as in patients with RA.
CONCLUSION : The centenarians present a positive picture of ageing , which counteracts negative stereotypes.
CONCLUSION : The CES-D @number@ Scale indicated adequate reliability and validity for the community-dwelling older population in China.
CONCLUSION : The characteristics and mortality factors for AKI vary by age in China.
CONCLUSION : The Chinese version of WHOQOL-OLD showed good feasibility , reliability and validity in this study.
CONCLUSION : The classification of @number@ glabellar patterns is compatible for the Chinese population despite different proportions.
CONCLUSION : The clinical appearance of the wounds examined in this study corresponded well with the parameters derived from the bioimpedance data.
CONCLUSION : The clinical features of cayenne aspiration are usually obscure and nonspecific which may lead to delay in diagnosis.
CONCLUSION : The clinical guidelines focused on management ( i.e. , diagnosis , assessment and treatment ) of recurrent falls in clinical routine.
CONCLUSION : The clinically important prevalence of CMC1 OA is @number@ to @number@ times higher in women than men.
CONCLUSION : The clinical manifestations of bvFTD appear to be associated with different and more distressing impacts on the caregiver sleep quality than SD.
CONCLUSION : The clinical picture of dementia portrayed in fictional movies is mild and may be misleading.
CONCLUSION : The cognitive and morphometric correlates of IPS measures indicate that complex IPS might be decomposed into the domain-specific components with corresponding neural underpinnings.
CONCLUSION : The cognitive domains of spatial abilities and processing speed predicted LS @number@ years later in the oldest-old.
CONCLUSION : The cold-induced decrease in skin temperature is related to age and BMI in patients with RP but not in controls.
CONCLUSION : The combination of an optimized intense pulsed light source with a non-ablative fractional laser during the same treatment session is safe and effective.
CONCLUSION : The combination of a pedometer and a mobile phone diary may enhance the quality of self-reported data in clinical studies.
CONCLUSION : The combination of lifestyle change and dental care in one program improved both glycemic and periodontal status in older patients with diabetes.
CONCLUSION : The combination of low total serum carotenoids and low physical activity , both modifiable risk factors , strongly predicted earlier mortality.
CONCLUSION : The complement cascade is a strategic target for GA therapy.
CONCLUSION : The complications rate observed in octogenarians was not significantly higher than non-octogenarians.
Conclusion : The conditions of pre-frailty and frailty levels were elevated with negative effects on the health of the elderly.
CONCLUSION : The contribution of atherosclerosis to aortic dilation was very weak , representing less than one seventieth of the contribution of age.
CONCLUSION : The contribution of these findings to the selection of intervention strategies is discussed.
CONCLUSION : The correlation between MMSE and ToL is good , but ToL test provides complementary information to the MMSE and vice versa.
CONCLUSION : The CP-FI-CGA has properties that resemble other published FIs and may be useful in busy clinical practice for grading degrees of frailty.
CONCLUSION : The CRS seemed to be set under the hypothetical theoretical model , and the scores might be interpreted by the norms showed.
CONCLUSION : The crude mortality rate from CRC has doubled in Chile in this period.
CONCLUSION : The current data provide a comprehensive starting point to understand the phenotype of PCOS across the lifespan.
CONCLUSION : The current results indicate that sensitivity to white matter microstructure is a promising avenue for AD biomarker research.
CONCLUSION : The current study confirms the age-prospective memory-paradox within one sample and with carefully matched laboratory and naturalistic tasks.
CONCLUSION : The current work provides evidence of a strong relationship between thigh muscle volume and physical function in the elderly.
CONCLUSION : The cut-off points used for muscle mass affect the reported prevalence rates for sarcopenia and , in turn , affect comparability between studies.
CONCLUSION : The data present a map of greater interaction with and dependency on the health care system with advancing age.
CONCLUSION : The data supports that there is an age-defined underutilization of internet and electronic devices to exchange HRI and CCC.
CONCLUSION : The decrease in CP permeability is in line with the age-related changes in CSF secretion observed in animals.
CONCLUSION : The deficiency of endogenous androgen contributes to a high prevalence of CAD in elderly males.
CONCLUSION : The DEMMI provides clinicians with an accurate and valid method of measuring mobility for geriatric patients in the subacute hospital setting.
CONCLUSION : The description of personality disorders in DSM-5 is confusing.
CONCLUSION : The diabetes epidemic remains a serious problem in this First Nation community.
CONCLUSION : The diagnosis of AD in population studies is a complex process.
Conclusion : The diagnostic accuracy of RSWA obtained with both visual and automatic methods was high and there was a general agreement between methods.
CONCLUSION : The diagnostic accuracy of the GPS-iv was preferable to that of the GPS-pv.
CONCLUSION : The differences in the use of psychosocial and informational services between immigrants and non-immigrants seem to be generally small.
CONCLUSION : The different passing methods with these optics did not result in a significant thermal change.
CONCLUSION : The different types of cross-linked HA have different behaviors in the dermis immediately after their injection.
CONCLUSION : The distance from ICA to ET varies between males and females.
CONCLUSION : The distribution of facilities at which cancer patients received treatment differed significantly according to cancer site , treatment modality , and patient age.
CONCLUSION : The dose-response for statins on new onset of diabetes suggests elderly women should not be exposed to higher doses of statins.
CONCLUSION : The early hypersecretion of GLP-1 leads to hyperinsulinemia and early normalization of glucose levels.
CONCLUSION : The early , outdoor biting behaviour of An. farauti documented @number@ years previously on north Guadalcanal was still exhibited.
CONCLUSION : The economic value added by improvements in patient-centered outcomes is very large.
CONCLUSION : The ECQ is a novel tool for the questionnaire-based evaluation of everyday competence among healthy subjects.
CONCLUSION : The effect after injection of mono-HA and bi-HA is generally comparable , although there was a trend in favor of mono-HA.
CONCLUSION : The effectiveness of prehabilitation has been demonstrated in cardiovascular surgery and probably in abdominal surgery.
CONCLUSION : The effect of BMD loss on risk of nonvertebral fracture may be greater in persons without a history of falls.
CONCLUSION : The effect of cigarette smoking should be considered in MRI studies of patients with severe mental illness.
CONCLUSION : The effects of music go beyond the reduction of behavioural and psychological symptoms.
CONCLUSION : The efficacy and safety of XEO among patients with skin types IV to VI is similar to that among persons with fairer skin.
CONCLUSION : The Elder-HD group showed poorer dietary quality and higher consumption of processed and ultraprocessed foods than the Elder-Healthy group.
CONCLUSION : The elderly population of Havana presents a vulnerable nutritional status in view of the prevalence of underweight and overweight.
CONCLUSION : The employment of ICSI in the absence of a male factor can reduce reproductive outcome in poor responder.
CONCLUSION : The establishment of accurate data on the number of people with dementia is essential in the planning of services and initiatives.
CONCLUSION : The existence of functional relations in a learning setting considerably changes the pattern of differences between younger and older adults ' performance.
CONCLUSION : The existent literature suggests that arts activities are helpful interventions within dementia care.
CONCLUSION : The experience of being a dementia caregiver may influence one's own attitude about accepting dementia screening for oneself.
CONCLUSION : The experience of repeated unemployment periods during working life is associated with more psychosocial distress in retired men and women.
CONCLUSION : The experimental hot chemical etching solution provides enhanced bonding for zirconia than sandblasting , and the bond strengths remain stable after artificial aging.
CONCLUSION : The extent of vasoregulatory capacity during aging decreases along with the decreasing basic MFV.
CONCLUSION : The findings are compatible with the hypothesis that there is an association between endogenously synthesized MUFAs and cancer death.
CONCLUSION : The findings call attention to efforts to promote social activities and interpersonal contacts within ALFs.
CONCLUSION : The findings demonstrate that Dupuytren's palmar fibromatosis is common and often present without overt contractures.
CONCLUSION : The findings emphasize the need for attention and resources to be shifted from disease-oriented to functional approaches in the older Russian population.
CONCLUSION : The findings from this research provide evidence that variations in APOE modify trajectories of serum cholesterol from midlife to late life.
CONCLUSION : The findings indicate that functional disability may contribute to subsequent depressive symptoms by reducing activities and social support.
CONCLUSION : The findings of the present study suggest that in the currently aging society , cardioembolic stroke is the most important stroke subtype.
CONCLUSION : The findings revealed the key roles of functional limitations and mental health in the construction of subjective age in Chinese oldest-old.
CONCLUSION : The findings show notable shortcomings in various aspects of dementia management by GPs.
CONCLUSION : The findings suggest an adaptive role for goal disengagement capacities in older adulthood.
CONCLUSION : The findings suggest that type @number@ diabetes mellitus is associated with cupular and free-floating deposits in the semicircular canals.
CONCLUSION : The first results of the use of IPDE @number@ in the LUTS treatment secondary to the HBP seem promising.
CONCLUSION : The fluorescence of composite restorations is dependent of the layering technique and is affected by the diet.
CONCLUSION : The FORTA List now reflects a wider consensus among experts , increasing its validity for clinical use.
CONCLUSION : The frequency of falls among older people was similar to those in other populations.
CONCLUSION : The function of OSBPL2 in the hearing process remains to be determined.
CONCLUSION : The goal of epilepsy management in the elderly goes beyond attainment of seizure control but should include improvement in quality of life.
CONCLUSION : The growing number of elderly people who have retained their teeth suggests an increase in treatment needs.
CONCLUSION : The GWR-based analysis is useful to characterize normal brain , determine significant regions of interest , and quantify healthy aging.
CONCLUSION : The HAI should be investigated further as a candidate phenotype for uncovering longevity-associated genes in humans.
CONCLUSION : The hand-grip strength test is a useful tool to identify persons at risk of mobility limitation.
CONCLUSION : The handwriting was characterized by unequal size among syllables and non-perpendicular alignment , which could be explained by several factors.
CONCLUSION : The health status of the elderly in Iran was similar to other countries in the world.
CONCLUSION : The health status of the elderly is to an extent determined by the circumstances in which they are born , grow and live.
CONCLUSION : The high-density textured insoles affected foot loading distribution during indoor rowing.
CONCLUSION : The hollow eye is filled durably in the time.
CONCLUSION : The identification of proper clinical outcomes and the validation of geriatric screening tools are needed for conducting sound and comparable clinical trials.
CONCLUSION : The identified targets now need to be further validated through in vitro and in vivo studies.
CONCLUSION : The impact of a WW can be quantified objectively by instrumented gait assessment.
CONCLUSION : The impact of education was observed when locomotion was associated with cognitive tasks.
CONCLUSION : The impact of NPFL role is rather novel in promoting healthy bone living at local , national , and international communities.
CONCLUSION : The impact of patient age to the cleavage dynamic has not been proved.
CONCLUSION : The implant can be used to treat both NVG and non-NVG in diabetic patients following PPV.
CONCLUSION : The incidence of cancer was significantly increased among kidney transplantation waiting list patients compared with the general population.
CONCLUSION : The incidence of falls and poor quality of life may be partially associated with the presence of depression.
CONCLUSION : The inclusion of the ratios in diagnostic criteria increases sensitivity and NPV for the diagnosis of MCI due to AD.
CONCLUSION : The increased frequency of central disc herniation with age suggest an important , and probably a cause-effect relationship , between herniation and myelopathy.
CONCLUSION : The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors.
CONCLUSION : The individualized and group formats of the WWE program improved arthritis-related pain , fatigue , and stiffness in African Americans.
CONCLUSION : The influence of the APOA2 -265T > C polymorphism on body-weight-related measures was modulated by saturated fat in Mediterranean and Asian populations.
CONCLUSION : The innovative methodological framework proposed in this scoping review protocol will yield richer information on the contribution of elders to community wellness.
CONCLUSION : The INQ yields reliable and valid scores of thwarted belongingness and burdensomeness when administered orally using a shortened response scale with older adults.
CONCLUSION : The integration of visual and haptic signals appeared to obey a Bayesian model optimizing the reliability of the multimodal estimate.
CONCLUSION : The interaction between CD147 and CyPA might play an important role in the process of skin aging.
CONCLUSION : the intervention improved performance on risk factors for falls but did not reduce the rate of falls.
CONCLUSION : The intervention model reduced high-risk medication use in older inpatients.
CONCLUSION : The investigational product was effective and may be better tolerated than tretinoin cream.
CONCLUSION : The IPE programs for dementia should be expanded and must be widely implemented in order to assess the impact on collaborative practice.
CONCLUSION : The judgment about the benefits of new treatment options largely differs between groups , physicians being the most critical against therapy.
CONCLUSION : The Kemp Quality of Life Scale relates significantly to clinically relevant variables in adults with impairments.
CONCLUSION : The knee cartilage degenerates in the HIF-1alpha cKO mice , and the degeneration increased with age adding.
CONCLUSION : The knowledge and perception of HRT is poor and limited.
CONCLUSION : The LDS procedure is a safe and effective treatment for morbid obesity and its associated co-morbidity in selected patients.
CONCLUSION : The limited available evidence suggests that some strategies are more successful than others in effectively deprescribing inappropriate PPIs in older adults.
CONCLUSION : The literature reviewed provides the accelerometer as a reliable and effective method to assess physical activity.
CONCLUSION : The longitudinal findings among older employees could be relevant regarding the expected need to remain occupationally active longer.
CONCLUSION : The low agreement on health and treatment priorities between patients and physicians necessitates better communication between the two parties to strengthen mutual understanding.
CONCLUSION : The lower predictive power of physical and mental functioning on SPSA among O-O relative to Y-O adults is particularly noteworthy.
CONCLUSION : The LSCS group showed greater segmental motion , higher VEGF concentrations , and more CD34-positive capillaries than the control group.
CONCLUSION : The MacCAT-CR is currently the most used and the best validated questionnaire.
CONCLUSION : The MADeN was able to predict dementia in a population of older Mexican-American adults with moderate accuracy.
CONCLUSION : The majority of nursing home residents with advanced dementia are admitted to SNFs after a qualifying hospitalization.
CONCLUSION : The majority of older patients in the rehabilitation setting are nutritionally compromised which adversely influences LOS.
CONCLUSION : The majority of respondents wished to have children , but many desired to have these after the biological decline in female fertility.
CONCLUSION : The majority of the children ( @number@ % ) did not show any relevant lung function changes.
CONCLUSION : The MBI-C provides the first measure specifically developed to assess the MBI construct as explicitly described in the criteria.
CONCLUSION : The MBSR and exercise training evaluated in this study failed to enhance immune responses to influenza vaccine.
CONCLUSION : The MCQ revealed to be a heuristic tool for assessing daily compensatory behaviors that are developed in order to achieve successful aging.
CONCLUSION : The mean BMI and prevalence rates of overweight and obesity decreased in the last 10-year period , 2001-2010.
CONCLUSION : The median duration of hot flushes considerably exceeded the timeframe that is generally accepted in clinical practice.
CONCLUSION : The Mediterranean dietary pattern as captured by the MedDiet scoring system may reduce the rate of cognitive decline with older age.
CONCLUSION : The Memory-HEARS intervention is a low-cost , low-risk , nonpharmacologic approach to addressing hearing loss and behavioral symptoms in patients with dementia.
CONCLUSION : The mental QoL significantly decreased and patients with preoperative depressive symptoms had mental QoL improvement at six months.
CONCLUSION : The meta-analysis suggests a moderate inverse association of 25 ( OH ) D concentration with total cancer incidence and mortality.
CONCLUSION : The method proposed to analyse SSMT three dimensionally is an effective tool with which to characterize the condition of the skin.
CONCLUSION : The MHR decreased with age.
CONCLUSION : The MIC of both the Katz-ADL index and the Lawton IADL scale lie around half a point.
CONCLUSION : The microscopic characteristics of the sublingual glands in mouth floor enlargements in edentulous patients correspond to characteristics associated with the normal aging process.
CONCLUSION : The MNA and MNA-SF were useful tools to identify older Chinese inpatients with malnutrition.
CONCLUSION : The MNA has gained worldwide acceptance and shows a high prevalence of malnutrition in different settings , except for the community.
CONCLUSION : The MNA-SF has at least comparable or even slightly better ability in predicting follow-up 4-year mortality risk of elderly Taiwanese.
CONCLUSION : The moderating effect of communication difficulty may be explained by the interaction between depression and communication difficulty.
CONCLUSION : The more positive scenarios provide a framework for determining relevant actions in research , society , and politics.
CONCLUSION : The mortality rate of severe influenza patients admitted to the ICU was high , especially in middle-aged adults.
CONCLUSION : The mortality was not increased among Danish HHT patients compared to controls.
CONCLUSION : The most affected HRQoL domains are of the physical , psychoemotional , and cognitive domains.
CONCLUSION : The most frequent causative organism of IE was S. viridians , both in the 1990s and 2000s.
CONCLUSION : The multimorbidity frailty index was highly associated with all-cause mortality , unplanned hospitalization and ICU admission.
CONCLUSION : The muscle endurance program provided a significant improvement in static and dynamic balance among community-dwelling elderly people.
CONCLUSION : The MusEQ provides a meaningful and reliable option for measuring music engagement among participants who are unable to complete a self-report questionnaire.
CONCLUSION : The Naturalistic Action Test is a useful tool that can increase diagnostic accuracy in differentiating Mild Cognitive Impairment from early dementia.
CONCLUSION : The Nautilus Survey of CVD indicates determining factors associated with the beginning and progression of CVD in three different age segments.
CONCLUSION : The neurodegenerative process underlying dementia overshadows formerly significant predictors of cognitive change.
CONCLUSION : The newly developed SPCIT program drastically improves knowledge , attitudes and perceived skills of general surgery residents.
CONCLUSION : The NHSC's PAs and NPs are well matched to communities and satisfied with their work.
CONCLUSION : The normal range of serum GA for the Chinese population could be suggested at 11%-17%.
CONCLUSION : The NORRE study provides the reference values for the most useful Doppler parameters in the evaluation of heart physiology.
CONCLUSION : The novel motion stimulator will be an invaluable tool to investigate how motion information is integrated across multiple digits.
CONCLUSION : The @number@ , 927-nm fractional thulium fiber laser is a safe , effective treatment for nonfacial photodamage.
CONCLUSION : The @number@ hS generated a prolonged response of the immune system.
CONCLUSION : The number of older PLWHA increased steadily over the study period in low HIV endemic provinces of a developing country.
CONCLUSION : The observed upward trend in albumin variability seems to be consistent with a presumed aging-related decline in homeostatic capacity.
CONCLUSION : The older adults presented better back endurance than young adults during a dynamic trunk extension exercise.
CONCLUSION : The outcome of the NOSE and SNOT questionnaires show no deterioration of quality of life in elderly related with changes in nasal function.
CONCLUSION : The outsourced HEPA programme had high retention and reasonable adherence.
CONCLUSION : The overall decline in MWSS observed with age may be due to a decrease in flow.
Conclusion : The overall lack of association between maternal PHIV status and preterm delivery or infant BW outcomes is reassuring.
CONCLUSION : The OWL protocol has been successfully implemented in a service , and preliminary data warrant a clinical trial of the intervention.
CONCLUSION : The parameters of @number@ nm PDL used in this study are effective and safe in the treatment of facial lentigines.
CONCLUSION : The past three decades brought strong and heterogeneous changes in cardiovascular risk factor distributions.
CONCLUSION : The PDQ-8 is a valid and reliable instrument assessing health-related quality of life for PD patients in the mainland of China.
CONCLUSION : The peak incidence of tracheal invasion from thyroid cancer was observed at ages of > 70years.
CONCLUSION : The percentage of clinical effort that providers devote to NHs is associated with risk of avoidable hospitalization.
CONCLUSION : The percentage of organic ED tends to grow with the increase of age , while that of psychological ED is just the opposite.
CONCLUSION : The percentage of taking part in moderate and vigorous activities among floating population was generally low.
CONCLUSION : The performances of fecal occult blood quantitive testing instrument might be better than colloidal gold strip method in colorectal cancer screening.
CONCLUSION : The Persian version of the BBS has excellent interrater reliability and internal consistency for the assessment of PD patients.
CONCLUSION : The photographic scale is reliable and easy to use.
CONCLUSION : The PHQ-2 is a valid tool for screening depression in PD.
CONCLUSION : The PHS FI outperformed mSOF in identifying risk of death particularly in robust and pre-frail categories.
CONCLUSION : The platysma muscle may have a more significant facial extension than previously described.
CONCLUSION : The PL-biofilm thickness remained practically constant , decreasing the bacterial vitality and increasing the covering grade over time.
CONCLUSION : The Polish language version of the DemTect® scale is easy to administer.
CONCLUSION : the poor patient rating of MMDs which are widely used in practice is of concern.
CONCLUSION : The population of New Zealand is aging and the number of older people with multiple chronic conditions is increasing.
CONCLUSION : The population PWV values were higher than expected in a low cardiovascular risk area ( Portugal ) .
CONCLUSION : The Portuguese version of Positive VOL Scale represents a reliable and valid measure to capture the subjective experience of attachment to one's life.
CONCLUSION : The positive correlation between SPT and sIgE reaction to HDM varied according to the age of patients with AR.
CONCLUSION : The positivity effect worked by choosing positive stimuli rather than avoiding negative stimuli.
CONCLUSION : the predictive value of multimorbidity for the increase in ADL disability varies with cognitive function in very old people.
CONCLUSION : The preliminary results suggest no differences in D₂ / ₃R availability between antipsychotic-free older patients with schizophrenia and controls.
CONCLUSION : The pre-presbyopic human accommodative system is robust to fatigue during intense and prolonged near work.
CONCLUSION : The presence of a systemic disease may worsen the status of the posterior labyrinth causing a more frequent otolith detachment.
CONCLUSION : The presence of chronic diseases was reported by most respondents , and the practice of self-medication is significantly more frequent among the aged.
CONCLUSION : The presence of dementia in the family creates interpersonal dilemmas that caregivers experience.
CONCLUSION : The presence of disability and diverse chronic conditions has a negative effect on QoL of older adults affected by multimorbidity in Spain.
CONCLUSION : The presence of high depressive symptoms did not substantially diminish physical performance benefits realized after a PA intervention in sedentary older adults.
CONCLUSION : The present analyses found significant correlations between degree of urbanization with self-reported rhinitis symptoms and sensitization to inhalant allergen in the elderly population.
CONCLUSION : The present analysis demonstrates a clear pattern of negative age effects in spatial ability across the literature.
CONCLUSION : The presented data on average voice characteristics may be applicable in the clinical practice and provide relevant support for voice assessment.
CONCLUSION : The present findings demonstrate that blood viscosity increases with age.
CONCLUSION : The present findings suggest that older adults show no age-related alterations in MI for familiar movements.
CONCLUSION : The present results provide support for previous findings demonstrating that experiencing depressive symptoms affects the ability to regulate emotional responses.
CONCLUSION : The present results suggest that miR-196a2 expression is decreased in active intestinal BD patients.
CONCLUSION : The present study clearly shows that malnutrition may play an important role in the progression of cognitive loss.
CONCLUSION : The present study demonstrates that the airway in neonates and infants between the subglottic area and the cricoid remains elliptical.
CONCLUSION : The present study does not give evidence that hearing aid benefit is critically associated with cognitive function in experienced hearing aid users.
CONCLUSION : The present study emphasized the role of analyzing individual differences in subjective organization.
CONCLUSION : The present study found a low prevalence rate of the agenesis of frontal sinuses in dry skulls with metopism.
CONCLUSION : The present study highlighted some variables related to stent encrustation and seems to be the first one analyzing separately the two coils.
CONCLUSION : The present study provides evidence that LLD is a risk factor for all-cause mortality in the elderly , especially in men.
CONCLUSION : The present study provides preliminary evidence suggesting that older age does not preclude postbariatric surgery cognitive benefits.
CONCLUSION : The present study revealed that normal perimenopausal and postmenopausal phase are associated with oxidative stress.
CONCLUSION : The present study showed a high prevalence of US inflammatory abnormalities in the knee joints of a normal aged population.
CONCLUSION : The present study showed that higher uric acid levels were linearly associated with higher lumbar spine BMD in peri- and postmenopausal Japanese women.
CONCLUSION : The present study shows that PEMF therapy improves pain , stiffness and physical function in elderly patients affected by knee osteoarthritis.
CONCLUSION : The present study stresses the relationship between falls and subjective well-being.
CONCLUSION : The present study supports that there is an association between retirement age and age at onset of AD.
CONCLUSION : The present study was able to confirm that in very elderly individuals , systemic inflammatory activity is independently associated with coronary atherosclerosis burden.
CONCLUSION : The prevalence of concurrent prescription drugs and HMP use among older adults is substantial and potential interactions have been reported.
CONCLUSION : The prevalence of frailty among young adult CCS is similar to that among adults @number@ years old and older , suggesting accelerated aging.
CONCLUSION : The prevalence of LBP in active workers was associated with occupational exposure.
CONCLUSION : The prevalence of MetS is related to obesity and elevated serum uric acid.
CONCLUSION : The prevalence of obesity emphasizes the need for concentrated efforts to prevent obesity in the early age.
CONCLUSION : The prevalence of osteoarthritis was generally high in middle and old-aged people in Heilongjiang province.
CONCLUSION : The prevalence of peripheral artery disease in the elderly is high in Africa , especially in females.
CONCLUSION : The prevalence of poor masticatory function is high among Iranian adults.
CONCLUSION : The prevalence of subclinical atherosclerosis was @percent@ among HIV-infected adults in Uganda.
CONCLUSION : The prevalence of the elongated styloid process in the present study was higher in comparison to the other reports from edentulous patients.
Conclusion : The prevalence of TMD was significant among the elderly population.
CONCLUSION : The prevalence of undernutrition is high in the older population.
CONCLUSION : The primary finding is that FO mediates the relationship between close attachment style and caregiver preparedness among prospective caregivers.
CONCLUSION : The prognosis of AKI in elderly patients is not necessarily worse than in middle aged individuals.
CONCLUSION : The program has proven to be successful and sustainable.
CONCLUSION : The promotion of successful aging is increasingly becoming important in aging societies.
CONCLUSION : The pronounced deficit observed in the focal PM task suggests that spontaneous retrieval processes may be compromised in very early AD.
CONCLUSION : The propensity of RBCs to undergo P2X7-mediated PS exposure does not alter during in vivo and ex vivo aging.
CONCLUSION : The proposed method identifies four CpGs which can be mapped to two biologically relevant and functional genes.
CONCLUSION : The proposed model could reflect the targeted trabecular changes in proximal femur with age.
CONCLUSION : The psychological needs category of the CANE appeared to be the strongest predictor of depression severity.
CONCLUSION : The QoL for carers of EOD patients corresponds positively with the increased age of carers and with patients ' insight into their condition.
CONCLUSION : The range of tactile experience reported in a convenience sample of the population was apparently insufficient to preserve sensory function during aging.
CONCLUSION : The rapid rise in chronic diseases has resulted in an increased burden of disability among the oldest old in China.
CONCLUSION : The rate of return to work after lung transplantation in Germany is similar to the rates observed in other countries.
CONCLUSION : The rates of mortality attributable to RA have declined globally.
CONCLUSION : The RealAge score is a valid measure of mortality risk in its user population.
CONCLUSION : There are complex associations between malnutrition risk and the gender-cohabitation interaction , age , general health , tiredness , and risk of falling.
CONCLUSION : There are measurable and identifiable differences in the patterns of health services utilization among older adults.
CONCLUSION : There are racial differences in age-related changes in the eyelids , which are more marked in Japanese subjects.
CONCLUSION : There are significant differences between characteristics of hospice patients in different settings , as well as the mix of services they receive.
CONCLUSION : The reference range for half-time of gastric emptying with instant oatmeal decreases with increasing age in both men and women.
CONCLUSION : Therefore , adenosine and inosine may represent novel agents lowering the risk of arterial thrombosis.
CONCLUSION : There had been a high incidence of mental disorders after falling among the elderly.
CONCLUSION : There is a certain connection between hand and face-mouth.
CONCLUSION : There is a deficit of studies quantifying balance , gait and PA in patients with lower extremity sarcoma.
CONCLUSION : There is a distinct septum between the lateral-temporal and the middle fat compartments of the face.
CONCLUSION : There is a high prevalence of cognitive dysfunction among hemodialysis patients and many causative factors have been evoked.
CONCLUSION : There is a need for frailty measures that are psychometrically sound and feasible to administer in primary care.
CONCLUSION : There is a need for future trials with more rigorous randomization and longitudinal follow-up to assess family caregiver burdens at different illness stages.
CONCLUSION : There is a need to move towards more ecological models of resilience.
CONCLUSION : there is an increased risk of multiple falls , but not single falls , in older people with poorer gait.
CONCLUSION : There is an interrelationship between the nutritional status of the elderly and reduced functional capacity.
CONCLUSION : There is a perception that NPs , as compared with PCMDs , tend to provide care to healthier patients.
CONCLUSION : There is a wide variation in the appearance of the caudate tail adjacent to the temporal horn of the lateral ventricle.
CONCLUSION : There is considerable variation in reports of sleep disturbance across different European countries.
CONCLUSION : There is evidence that brain structure is associated with muscle structure and function.
CONCLUSION : There is insufficient data to recommend the optimal conservative management for osteoporotic vertebral fractures.
CONCLUSION : There is no difference between the serum vitamin D level and receptor gene polymorphism among children with recurrent tonsillitis and healthy children.
CONCLUSION : There is no need for the conservative use of megaprostheses in revision arthroplasty.
CONCLUSION : There is no proscriptive formula for evaluating the intricate nuances of technology acceptance and use in the aging-in-place context.
CONCLUSION : There is presently no evidence to suggest long-term survival rates improved in patients with advanced dementia who underwent PEG placement for dysphagia.
CONCLUSION : There is strong evidence of a correlation between pain severity and QoL.
CONCLUSION : There is substantial evidence that CIMT is a suitable surrogate for the coronary tree.
CONCLUSION : There is urgent need to expand the number of graduates with academic education and clinical training in geropsychology and -psychotherapy.
CONCLUSION : The relationship between cognitive and aerobic endurance change varies as a function of IGF-1 in persons with MCI.
CONCLUSION : The relationship between height and SBP was attenuated by development in females and the relationship between height and DBP disappeared.
CONCLUSION : The relative risk for PE in the very elderly is not higher than that in the elderly.
CONCLUSION : There may be different QoL trajectories for older women undergoing breast cancer chemotherapy on- vs. off-trial.
CONCLUSION : The reporting of a higher number of SLEs is associated with greater risk of impaired systolic BP recovery from orthostatic stress.
CONCLUSION : The response rate was lower and myelosuppression was more frequently observed than in other previous reports.
CONCLUSION : The resulting valuations form the basis for clinical use and facilitate the interpretation and evaluation of health care.
CONCLUSION : The result of this study has shown that approximately one fifth of patients over 60years had at least one lifetime ICD comorbidity.
CONCLUSION : The results are interpreted as support for the hypothesis that older adults adopt \ "risky \ " strategies during sentence comprehension.
CONCLUSION : The results clearly indicate that using the mean BMIs as the only indicator might be misleading in weight management studies.
CONCLUSION : The results confirm that EANN is appropriate to approximate such a complicated , non-invasive and highly non-linear problem as body composition analysis.
CONCLUSION : The results demonstrated that partical blockade of RAGE activation by sRAGE prevent AngII -induced atherosclerosis.
CONCLUSION : The results demonstrate that individuals ' belief about aging has effects on physical activity in Korean middle aged adults.
CONCLUSION : The results demonstrate the relationship between cognitive function and frontoparietal functional activation in hypertension and their relevance to cognitive aging risk.
CONCLUSION : The results depict specific patterns of loss and stability of functional capacity in community-dwelling elderly.
CONCLUSION : The results do not support the hypothesis that major depression is associated with dementia-related pathology.
CONCLUSION : The results from this study indicate that exergame intervention can enhance knee proprioception in elderly men.
CONCLUSION : The results highlight the importance of need factors in the utilization of bereavement services.
CONCLUSION : The results highlight the need for increased education , communication , and future research on these predictive factors.
CONCLUSION : The results indicate greater risk of PSF in older adults with difficulty staying asleep and those who use sleep-promoting medications.
CONCLUSION : The results indicate that diagnosis , functional level , sex and motivation are significant predictors of outcomes following reablement.
CONCLUSION : The results indicate that thresholds for serum 25 ( OH ) D may vary according to different outcomes and subgroups.
CONCLUSION : The results of our study indicate that the Katz-15 scale is able to reliably and validly predict future unfavorable health outcomes.
CONCLUSION : The results of our study support an independent association between low 25OHD levels and cognitive decline in elderly individuals.
CONCLUSION : The results of the current study suggest that the menopause may be associated with hippocampal volume reduction.
CONCLUSION : The results of the present study confirm a progressive increase of crow's feet and forehead and glabellar lines in men and women.
CONCLUSION : The results of the problem-solving intervention showed no positive effects on the three outcome measures compared to business as usual.
CONCLUSION : The results of the study encourage the implementation of a Nutrition Coordinator program to maintain nutritional status of aged care residents.
CONCLUSION : The results of this study indicate that aging-related changes in muscle quality contribute to diminishing muscle strength.
CONCLUSION : The results of this study suggest that a lower dose equivalence between DYS and XEO could be established.
CONCLUSION : The results of this study suggest that MetS may be an independent risk factor for decreased renal function in older population as well.
CONCLUSION : The results of this trial are expected to directly influence decision making in these patients.
CONCLUSION : The results provide an important insight into being ascribed a higher social status is likely to have a protective function for older people.
CONCLUSION : The results showed that the MNA-SF can be a useful tool in identifying elderly patients at higher risk for 1-y mortality.
CONCLUSION : The results showed that the rural ageing population is deprived and a targeted programme to spread scientific dental practices to them is necessary.
CONCLUSION : The results show that GPs recognise MCI in a very limited number of cases when based on clinical impression only.
CONCLUSION : The results show that involvement in BSN could contribute positively to functional health , particularly with regard to advanced ADL.
CONCLUSION : The results suggest a heel cup with arch support insole is effective in enhancing the standing balance of the elderly.
CONCLUSION : The results suggest a progressive temporal extension of PPVP during childhood.
CONCLUSION : The results suggest that dMCI patients who progress relatively quickly over @number@ years may have unique clinical and brain MRI features.
CONCLUSION : The results suggest that filial piety and family solidarity should be considered when developing elder care policy and interventions to promote psychological well-being.
CONCLUSION : The results suggest that self-reported snoring and daytime sleepiness status are associated with an increased risk of future cardiovascular disease among older adults.
CONCLUSION : The results suggest that serum UA levels are significantly lower in AD patients in comparison to control subjects.
CONCLUSION : The results suggest that several problems still remain for controlling tuberculosis in rural China.
CONCLUSION : The results suggest that temporal sequence learning deficits are detectable in aMCI.
CONCLUSION : The results suggest that the promoter hypermethylation of HIST1H4K is rather due to aging than related to prostate carcinogenesis.
CONCLUSION : The results suggest that the relation between BMI and cognitive function does vary by race ethnicity.
CONCLUSION : The results suggest that thought suppression causes significant cognitive decline.
CONCLUSION : The results suggest the importance of treatment-specific competencies for outcome.
CONCLUSION : The results suggest the program was successful in enhancing the health and well-being of those community-dwelling older adults who stayed in the program.
CONCLUSION : The review indicates that Wii-based exercise programs may serve as an alternative to more conventional forms of exercise aimed at improving balance control.
CONCLUSION : The review revealed a major knowledge gap in regards to the impact of retirement on cognitive decline.
CONCLUSION : There was a clear trend of deterioration with advancing years when comparing severity to age.
CONCLUSION : There was a highly significant correlation between volumetric measurements of the hippocampus and MTA scoring.
CONCLUSION : There was a high retention rate after @number@ months.
CONCLUSION : There was appreciable efficacy and patient satisfaction after a single microfocused ultrasound with visualization treatment in wrinkle reduction and lifting of the décolletage.
CONCLUSION : There was a relationship between kinematic changes , representing the motor planning strategies , and physical frailty in these aged adults.
CONCLUSION : There was a significant association between subjective cognitive and sleep complaints , and daytime sleepiness in our population of older people.
CONCLUSION : There was consensus regarding the major curricular areas that online resources should encompass.
CONCLUSION : There was no association between age and TA in bone marrow hematopoietic cells.
CONCLUSION : There was no statistically significant relationship between MPOD and increasing age for three of the four locations measured.
CONCLUSION : There were differences also on adjustment , this time favoring only the Low Risk Groups.
CONCLUSION : There were gender differences in EPT values across all ages.
CONCLUSION : There were no changes in conventional audiological and high-frequency evaluation , or in the central auditory processing.
CONCLUSION : There were significant associations of sleep duration with either obesity or sarcopenia in community-dwelling older adults.
CONCLUSION : There were some significant differences in the microbial community structure between aged and aging pit mud.
CONCLUSION : There were substantial variations across countries and settings , even between upper-middle income countries and lower-middle income countries.
CONCLUSION : The risk factors of chronic diseases were highly prevalent in Shanghai.
Conclusion The risk of overexposure to erlotinib increases with age.
CONCLUSION : The risk of overweight at the age of @number@ years can be predicted with six characteristics that are available at birth.
CONCLUSION : The risk test appears to be a more effective screening tool in our population.
CONCLUSION : The role of elevated cholesterol in the occurrence of NPS in AD appears to be gender and symptom specific.
CONCLUSION : The RS-CN is a valid and reliable instrument for the measurement of the concept of resilience in Chinese older people.
CONCLUSION : The RUD instrument appears to accurately estimate the amount of informal care provided by caregivers to dementia patients.
CONCLUSION : The sample of nurses ' knowledge to some recommendations is frequently low.
CONCLUSION : The scale is ready to be used to assess the quality of services provided by home care nursing organizations.
CONCLUSION : These applications presented satisfactory results as an auxiliary method , in male images.
CONCLUSION : These are the first in man data demonstrating relation between changes in cognition and β2M.
CONCLUSION : These benefits may lead to reinforcement of the skin organization and structure.
CONCLUSION : These data illustrate that increasing plant-based foods and reducing animal-based products could have unintended consequences on protein intake of older Americans.
CONCLUSION : These data indicate that GA values can be used as a surrogate parameter for HbA1c in screening for prediabetes and diabetes mellitus.
CONCLUSION : These data provide preliminary support for a deleterious effect of elevated total cholesterol / HDL-cholesterol ratio on cerebrovascular support for cognition in midlife.
CONCLUSION : These data show that a healthy obesity phenotype is relatively unstable.
CONCLUSION : These data suggest that B-K fusion confers a less aggressive clinical phenotype on PLGA and may explain their tendency to growth arrest.
CONCLUSION : These data suggest that higher protein intake does not have a major effect on kidney function decline among elderly men and women.
CONCLUSION : These data suggest that infrequent and light-to-moderate drinking is associated with a lower risk of heart failure.
CONCLUSION : These data suggest that midlife cholesterol level is not associated with an increased risk of AD.
CONCLUSION : These data suggest that sex and age affect ventricular parameters in healthy Han Chinese subjects without cardiovascular disease or risk factors.
CONCLUSION : These data suggest the underutilization of basal insulin in the LTC setting and worryingly high combinational use with sliding scale insulin.
CONCLUSION : These data support a significant role of frailty as a predictor of depression in a relatively younger old Chinese population.
CONCLUSION : These data support the clinical significance of the CHRNA5 variant rs16969968.
CONCLUSION : These data support the hypothesis that relaxin alters gene transcription and suppresses inflammatory pathways and genes associated with HF and aging.
CONCLUSION : These data weakly corroborate prior findings of associations between LTL and mortality in the elderly.
CONCLUSION : These data would permit development of a national oncogeriatric policy through the action of regional oncogeriatric coordination units.
CONCLUSION : These estimates confirmed the epidemiological patterns in time trends of major cancer sites recorded in Friuli Venezia Giulia.
CONCLUSION : These findings allude to the possibility that secondary traumatization mold negative perceptions of the aging process among middle-aged offspring of traumatized parents.
CONCLUSION : These findings can guide professionals in targeting and monitoring interventions aiming to develop caregivers ' effective coping strategies.
CONCLUSION : These findings demonstrated that the final depressive symptoms of the elderly would differ from the elderly with developmentally different depressive related factors.
CONCLUSION : These findings emphasize the importance of considering the presence of pain at very early ages in CP.
CONCLUSION : These findings have implications for the development of positive psychological interventions to enhance resilience and well-being in older adults.
CONCLUSION : These findings illustrate the high symptom burden and poor HRQoL of the hemodialysis population.
CONCLUSION : These findings illustrate the mediating role of eating-related behaviors and the inter-locking nature of social support , behavior and consumption trajectories.
CONCLUSION : These findings indicate a role of dopaminergic regulation of gait speed in community-dwelling older adults and of prefrontal cortex involvement in gait performance.
CONCLUSION : These findings indicate that physical performance measures may be less predictive of short-term mortality in very old Mexican Americans than previously thought.
CONCLUSION : These findings indicate that the IgG-bound platelet-induced conversion of monocytes to regulatory cells might provide a novel strategy for controlling inflammation.
CONCLUSION : These findings provide compelling evidence that sleep optimizes motor skill performance across the adult life span.
CONCLUSION : These findings provided a basis for developing appropriate interventions to minimize the caregiver burden of spousal family caregivers.
CONCLUSION : These findings provide the first evidence of racial differences in placental telomere length.
CONCLUSION : These findings question the validity of single disease guidelines in old persons or in persons with multiple chronic diseases.
CONCLUSION : These findings revealed that cognitive tasks involving the visuo-spatial sketchpad interfered with gait more severely in older versus young adults.
CONCLUSION : These findings show that group identification is a key moderator through which reminiscence promotes health outcomes.
CONCLUSION : These findings suggest a dissociation between age-related changes in emotional versus cognitive characteristics of engaging with intrusive thoughts.
CONCLUSION : These findings suggest a role of short telomeres in the development of OA and in aging of articular cartilage.
CONCLUSION : These findings suggest Stroop performance is a poor measure of behavioral disinhibition and frontal lobe atrophy even among a relatively high-risk population.
CONCLUSION : These findings suggest that age-related slowing of gait speed is in part mediated by the decreased magnitude of saccular response associated with age.
CONCLUSION : These findings suggest that ANA are not strongly associated with mortality in the general population.
CONCLUSION : These findings suggest that both AD and PD neuropathology contribute to the pathogenesis of VH.
CONCLUSION : These findings suggest that both Ala1330Val and Val667Met LRP5 polymorphisms may affect the determination of geometric bone parameters in women.
CONCLUSION : these findings suggest that CA is not affected by healthy ageing.
CONCLUSION : These findings suggest that depressive PD features are strongly related to increased suicidal thinking and lowered resilience to suicide among older adults.
CONCLUSION : These findings suggest that functional role and muscle morphology are regionally affected by aging along the RF muscle.
CONCLUSION : These findings suggest that high perceived stress in mastocytosis could accelerate the rate of leukocytes telomere shortening.
CONCLUSION : These findings suggest that individuals with lower repetitive element methylation are at high risk of developing and dying from cancer.
CONCLUSION : These findings suggest that living arrangements of Chinese oldest old are partially getting westernized , and a majority of them adapt it well.
CONCLUSION : These findings suggest that [ ( @number@ ) F ] THK-5117 provides regional information on neurofibrillary pathology in living subjects.
CONCLUSION : These findings suggest that pronated foot function may contribute to low back symptoms in women.
CONCLUSION : These findings suggest that stimulation of the external auditory canal with ointment containing capsaicin improves swallowing function in elderly patients with non-obstructive dysphagia.
CONCLUSION : These findings suggest that systemic arterial stiffness may be associated with the severity of CSVD and pulsatility of cerebral arteries.
CONCLUSION : These findings suggest that telomere deficiency is implicated in the CHH disease phenotype through an as yet unidentified mechanism.
CONCLUSION : These findings suggest that the relationship between long-term mortality and dyspnea is strong , consistent and independent of other covariates in the elderly.
CONCLUSION : These findings suggest that the relationship between performance variability and executive control functions under some specific conditions.
CONCLUSION : These findings suggest that there may be a link between hippocampal atrophy and difficulties with lane control in persons with amnestic MCI.
CONCLUSION : These findings suggest that these cognitive dimensions may benefit neuropsychological diagnostics.
CONCLUSION : These findings suggest that TRT is an effective and safe treatment for aging Japanese men with LOH.
CONCLUSION : These findings support the view that aging may result in a compression of the neuro-behavioural repertoire.
CONCLUSION : These findings would advocate for prevention of WMHs to stave off excess medical resource utilization in patients with cognitive impairment.
CONCLUSION : These immunohistochemical findings show that changes in distribution and relative levels of CRP and CFH were evident in early and late AMD eyes.
CONCLUSION : The Self-Report HABC Monitor demonstrates good reliability and validity as a clinically practical multidimensional tool for measuring symptoms.
CONCLUSION : These new equations derived over @number@ mo during weight stability can be used to estimate the free-living caloric requirements of nonobese adults.
CONCLUSION : These new equations offer a valid option for assessing appendicular skeletal muscle mass in older Japanese adults.
CONCLUSION : The sensitivity of the mRASS to detect delirium in older ED patients was low , especially in patients with dementia.
CONCLUSION : These preliminary results suggest that FAM-CAM is a sensitive screening tool for family detection of delirium in elderly hospitalized adults.
CONCLUSION : These prospective findings indicate that VPA per se plays an important role in the prevention of functional decline.
CONCLUSION : These results are consistent with the hypothesis that smoking causes cognitive decline and loss of gray matter tissue in the brain over time.
CONCLUSION : These results confirm cross-sectional findings suggesting that unforgiveness is related to health.
CONCLUSION : These results demonstrate an association of ADS use by family caregivers and higher DHEA-S levels on the next day.
CONCLUSION : These results demonstrated that sun-induced changes of the SC hydration property vary with age and gender.
CONCLUSION : These results demonstrate that even in nonclinical populations , it is possible to differentiate component processes in episodic memory.
CONCLUSION : These results demonstrate the effectiveness of the BPSD protocol in reducing BPSD and improving staff self-efficacy and stress.
CONCLUSION : These results demonstrate the multifarious selective pressures acting across the mammal phylogeny driving lineage-specific adaptations of telomere associated genes.
CONCLUSION : These results demonstrate the need to develop novel strategies aimed at improving the quality of drug prescription.
CONCLUSION : These results emphasize the role of cognitive abilities for individual differences in task-specific learning of older adults.
CONCLUSION : These results expand upon previous observations indicative of age-related reductions in intramuscular [ ATP ] and dietary protein intake.
CONCLUSION : These results highlight areas in which dementia care needs further improvements.
CONCLUSION : These results highlight the value of analyzing IIV in addition to TSS during neuropsychological evaluation in older adults.
CONCLUSION : These results indicate that grey matter measured through VBM might not be a suitable endophenotype for schizophrenia.
CONCLUSION : These results indicate that SIRT1 may play a role in susceptibility to diabetic nephropathy in Japanese subjects with type @number@ diabetes.
CONCLUSION : These results indicate that the skin is prone to seasonal changes during winter , particularly in exposed areas.
CONCLUSION : These results may be explained by an inability of IE to assess pain correctly or by instruments providing false positive results.
CONCLUSION : These results might be explained by gender-specific genetic factors as well as by early life programming.
CONCLUSION : These results propose that the risk of subsequent depression in elderly is associated with frequency of contact with non-cohabitating adult children.
CONCLUSION : These results provide new insights on the involvement of the partner in decision-making.
CONCLUSION : These results provide one possible path in the culture change journey based on empirical findings.
CONCLUSION : These results reveal an autonomous circadian clock in chondrocytes that can be implicated in key aspects of cartilage biology and pathology.
CONCLUSION : These results shed new light on the processes related to apathy in aging and open up an interesting prospect for psychological interventions.
CONCLUSION : These results show that acute L-arg supplementation provides no ergogenic effect on blood flow and muscle performance in older women.
CONCLUSION : These results show that low male TT concentrations are predictive of hypertension , suggesting TT as a potential biomarker of increased cardiovascular risk.
CONCLUSION : These results suggest an association between polypharmacy and locomotion that medical comorbidities only partly explained.
CONCLUSION : These results suggested that MCI needs to be taken into consideration when testing older adults using TUG , besides age and gender factors.
CONCLUSION : These results suggest that aging causes changes in hair diameter and surface structure.
CONCLUSION : These results suggest that cognitive dispersion between domains may be a useful indicator of multitasking and daily living skills among older adults.
CONCLUSION : These results suggest that extensive endurance exercise training might be beneficial for maintaining cognitive function in elderly persons.
CONCLUSION : These results suggest that in a geriatric rehabilitation hospital a targeted individualized intervention falls prevention program is not effective in reducing falls.
CONCLUSION : These results suggest that LM-correct responses could relate to emerging brain alterations.
CONCLUSION : These results suggest that menopausal transition is accompanied with a decrease in food intake and an increase in appetite.
CONCLUSION : These results suggest that moderate exercise , such as self-paced one-time walking , induces beneficial psychologic effects in elderly adults.
CONCLUSION : These results suggest that PRP could be a potential therapeutic tool for the treatment of OA.
CONCLUSION : These results suggest that skeletal muscle size could be a major determinant of IntraMAT content regardless of age.
CONCLUSION : These results suggest that statin use did not increase decline in gait speed in community-dwelling older adults.
CONCLUSION : These results suggest that the major pathogenetic factors of DCM in children may be different from those in adults.
CONCLUSION : These results suggest that the subcutaneous tissue structure is related to wrinkle depth.
CONCLUSION : These results suggest that variations in resistin concentrations are not directly related to susceptibility to type @number@ diabetes.
CONCLUSION : These results support an inverse association between diabetes history and glioma risk.
CONCLUSION : These results support the hypothesis that stress shielding is a contributor to vertebral body bone loss and may increase fracture risk.
CONCLUSION : These results will be helpful for the treatment of patients and the ventilation of the different reproductive options.
CONCLUSION : The serum PCSK9 levels were higher in postmenopausal women than those in pre-menopausal women.
CONCLUSION : These tissue type-invariant DNAm age signatures in normal and cancer can be used to address important questions in developmental biology and cancer research.
CONCLUSION : The sGAG content of hip joint cartilage varied with aging in elderly people.
CONCLUSION : The shift from winter to summer exposure is confirmed in altering some facial pigmented signs among Chinese women.
CONCLUSION : The short-term safety profile of BoNT-A in cosmetic nonsurgical procedures was confirmed for all the three commercial formulations.
CONCLUSION : The simultaneous presence of high numbers of non-viable osteocytes within a dense network of viable osteocytes is unique for the bony otic capsule.
CONCLUSION : The simultaneous presence of several good lifestyle habits increases the beneficial effect of reducing the risk of developing depressive symptoms in older adults.
CONCLUSION : The Sisters in Motion intervention led to an increase in walking and a decrease in SBP at @number@ months.
Conclusion The smaller foot muscles appear to be affected by sarcopenia in older adults.
CONCLUSION : The SmartSkin fractional laser device improves photodamaged skin for at least three months.
CONCLUSION : The spectral-domain OCT yielded measurements that could be used for digital analysis of the chamber angle geometry.
CONCLUSION : The STARR procedure with two PPH-01 is a safe surgical procedure to correct ODS.
CONCLUSION : The stochastic model provides more accurate description of the empiric data compared with the corresponding polynomial model.
CONCLUSION : The strategy to address older persons at high risk of falling in the GP setting with a complex exercise intervention was successful.
CONCLUSION : The strong cohort effect we describe may influence the performance of early amyloid-based AD markers.
CONCLUSION : The study confirmed the monopolar radiofrequency method as an effective and safe treatment of SUI and vulvo-vaginal laxity.
CONCLUSION : The study data demonstrate that pelvic floor dysfunction is a common problem among women and it is strongly linked to childbirth and aging.
CONCLUSION : The study establishes age and gender-specific reference values for the screening and identification of lysosomal storage disorders in Indian population.
Conclusion The study findings suggest that demanding body postures have a stronger impact on health among older compared to younger employees.
CONCLUSION : The study found that approximately one in ten older adults used potentially inappropriate anticholinergic medications.
CONCLUSION : The study indicated that impairment in ADL performance is strongly associated with UI , more than CPS performance and comorbidities.
CONCLUSION : The study indicates that effects of a low-threshold PA intervention on health-related quality of life in residential aged care can be sustainable.
CONCLUSION : The study indicates that increased urine periostin levels can be detected in patients with type @number@ diabetes before the onset of significant albuminuria.
CONCLUSION : The study is expected to collect an enormous dataset of information on dapagliflozin- and comparator-using patients.
CONCLUSION : The study presents evidence of the construct , criteria and ecological validity for this protocol.
CONCLUSION : The study results imply that the brow does not drop in women with age.
CONCLUSION : The study results suggest that a significant amount of the loss of accommodation is due to changes in lens geometry.
CONCLUSION : The study results suggest that BAC positivity and , in turn , arteriosclerosis may have an antinomic relationship with breast cancer.
CONCLUSION : The study showed that EF as determined by the QGSPECT technique should be considered as gender-matched normative parameter.
CONCLUSION : The study shows that ADHD in older adults is associated with lower cognitive functioning in the attention / working memory domain.
CONCLUSION : The study suggests that the anchorage of the orbicularis muscle flap to the upper orbital rim reinforces the lower eyelid's anterior lamellae.
CONCLUSION : The study suggests that the automatic regulating device applied with wireless sensor for CBI is safe and effective for patients after TURP.
CONCLUSION : The survey has been a successful exercise in enabling a greater understanding of the current Haemophilia care landscape across Europe.
CONCLUSION : The symptom clusters identified in older patients typically included a larger and more diverse range of physical and psychological symptoms.
CONCLUSION : The systematic review demonstrates that CMI is effective for preventing falls in older adults in the short term.
CONCLUSION : The taken for granted discourses of ageing can implicitly affect how nurses interact with older people.
CONCLUSION : The technique provides similar values of MP optical density to previous reports.
CONCLUSION : The tentacle arms of the implant ensured mesh stability and broad defect overlap.
CONCLUSION : The tested materials showed sufficient puncture strength for orbital floor reconstruction in mint condition.
CONCLUSION : The Testosterone Trial should provide definitive information regarding the potential benefits of TRT in men ≥65 years of age.
CONCLUSION : The TFI is valid and reproducible for assessment of frailty syndrome among a Polish population.
CONCLUSION : The The incidence of ED is high in men with LUTS and increases with aging and the severity of LUTS.
CONCLUSION : The theoretical implications as well as the practical implications for developing and implementing late-life suicide prevention strategies are discussed.
CONCLUSION : The therapeutic care of this late functional deterioration requires regular monitoring check-ups in order to implement preventive measures and appropriate treatment.
CONCLUSION : The thickness of skull at the halo pin insertion site gradually increases with age.
CONCLUSION : The threshold of CSMP below which assistance is required to perform ADL in community-dwelling older women was identified.
CONCLUSION : The T ( @number@ ) -based BALI helps describe brain structural variability in AD , mild cognitive impairment and normal aging.
CONCLUSION : The total drinking water of children and adolescents in Shanghai was less.
CONCLUSION : The TPI not only improved the post-operative outcome of the patients , but also allowed a remarkable saving for the National Health System.
CONCLUSION : The treatment of choice for duodenal GISTs is complete surgical resection with negative resection margins.
CONCLUSION : The treatment outcome of Retinol @number@.2% / LR2412 @percent@ cream does not differ from the one of tretinoin @percent@ cream.
CONCLUSION : The TTCC is useful screening test for early detection of AD.
CONCLUSION : The Turkish-language version of the APQ-S is a psychometrically valid and reliable instrument for the assessment of aging perceptions among elderly Turkish migrants.
CONCLUSION : the two depression questions perform well as an initial screening process for non-cognitively impaired older people in the acute medical setting.
CONCLUSION : The type and size of social networks have a role in the relationship between loneliness and depression.
CONCLUSION : The Ukrainian FRAX model should enhance accuracy of determining fracture probability among the Ukrainian population and help to guide decisions about treatment.
CONCLUSION : The underlying pathology of renal disease in HIV-infected patients is highly variable and evolving.
CONCLUSION : The upper platysma muscle plays a relevant role in the functional anatomy of the lower face that can be modulated safely with neuromodulators.
CONCLUSION : The urinary aMTS6 level did not differ between subjects with and without senile cataracts.
CONCLUSION : The use of adult diapers and UCs during acute hospitalization is associated with the development of new UI at discharge.
CONCLUSION : The use of infrared radiation represents a valid alternative to surgical lifting , but cannot replace it.
CONCLUSION : The use of PAM can be guided by patient severity.
CONCLUSION : The use of type profiles has potential to contribute to the knowledge of combinations of functional limitations among groups of older persons.
CONCLUSION : The verbal retrieval functions begin to mature in early adolescence and continue to grow up to adulthood.
CONCLUSION : The views and practices of many health professionals are inconsistent with current best practice.
CONCLUSION : The views of older people and physiotherapists were sought to understand the adoption of a previously successful home-based program for mild balance dysfunction.
CONCLUSION : The weight of the evidence from comparative clinical trials indicates that incobotulinumtoxinA , onabotulinumtoxinA , and abobotulinumtoxinA have similar efficacy for aesthetic applications.
CONCLUSION : The Women's EMPOWER survey showed that VVA continues to be an under-recognized and under-treated condition , despite recent educational initiatives.
CONCLUSION : The WTMT is of interest in that it can help provide early detection of dysexecutive cognitive impairment.
CONCLUSION : Thiazide diuretics should be the first-line agents in uncomplicated , isolated systolic hypertension.
CONCLUSION : Thickening of the LF is correlated with disc degeneration , aging , BMI , LSS , spinal level , and disc herniation.
CONCLUSION : Thirty-day mortality and complication and FTR rates increase with age after nonemergent general surgeries.
CONCLUSION : This article presents data for a normal range of straw drinking speeds in a healthy adult population.
CONCLUSION : This association proved to be therapeutically more effective than tretinoin or microencapsulated retinol used singly.
CONCLUSION : This case highlights a potential risk of dietary supplements.
CONCLUSION : This case illustrates the benefit of integrating PBR exercises into a standard SNF rehabilitation program , which may contribute to decreased fall risk.
CONCLUSION : This comprehensive meta-analysis provides confirmatory evidence that multiple SORL1 variants in distinct linkage disequilibrium blocks are associated with AD.
CONCLUSION : This CRAMP ELISA could become a powerful tool for investigating the relationship between human aging and telomere length shortening.
CONCLUSION : This cross-sectional survey suggests that aesthetically oriented women have changing facial treatment preferences with age ; however , CFLs are of most concern.
CONCLUSION : This data suggest that body composition , functional fitness , psycho-social factors , and falls are important correlates of HRQoL in old age.
CONCLUSION : This education empowerment intervention was very effective in enhancing participants ' outcomes.
CONCLUSION : This e-health promotion initiative is an example of how computer-assisted instruction may be developed to teach carers of older people.
CONCLUSION : This experimental study proves that hybrid and titanium abutments have similar mechanical properties.
CONCLUSION : This experimental study using aged IOLs demonstrated that surface light scattering does not influence paraxial forward scattering.
CONCLUSION : This finding demonstrated that less muscle co-activation of the trunk was related to locomotive instability in elderly adults.
CONCLUSION : This finding indicates that patients with potentially poor renal function are likely to have increased AUC values and a poor prognosis.
CONCLUSION : This findings show that guar gum could be effective on postprandial drops in blood pressure in older female adults.
CONCLUSION : This guideline provides a framework for physicians who wish to perform safe and efficacious injections of BTA in Asians.
CONCLUSION : This indicates that STR genotypes that are absent in the control group may be risk factors for SCZ.
CONCLUSION : This intervention was associated with modest long-term body-composition changes ; the findings were more robust in years @number@ and @number@
CONCLUSION : This is alarming given that hoarding patients utilized health services less than typical for older adults.
CONCLUSION : This is one of the largest series performed in a population of adult HPVG patients in the ED.
CONCLUSION : this is one of the pioneering studies that assess only the male population , showing that nocturia was not significantly associated with falls.
CONCLUSION : This is the first demonstration for association of the CNTNAP4 gene and one of its intronic CNV polymorphisms with aging.
CONCLUSION : This is the first demonstration of an association between serotonin transporter polymorphism and functional connectivity in older adults.
CONCLUSION : This is the first published incidence rate of acute myeloid leukemia ( AML ) in Canada across all age groups.
CONCLUSION : This is the first qualitative study of primary care experiences among patients with symptomatic foot OA.
CONCLUSION : This is the first report of a genome-wide significant association with replication for a novel phenotype , namely PPL TG response.
CONCLUSION : This is the first report on the use of high-resolution ultrasound imaging to assess the efficacy of fractional laser operating with standard parameters.
CONCLUSION : This is the first study in the current literature to demonstrate that spinal growth follows CGFRC rather than HVL.
CONCLUSION : This is the first study in which a systematic evaluation of the UA was followed by a sleep study in a population-based sample.
CONCLUSION : This is the first study to compare adherence to PA recommendation , using absolute and relative intensity thresholds among older adults.
Conclusion : This is the first study to examine normative performance on the MoCA specific to community-dwelling African Americans.
CONCLUSION : This is the first study to investigate prospective memory in FTD syndromes.
CONCLUSION : This is the largest prospective study of CGA assessments done on elderly patients with cancer in Asia.
CONCLUSION : This is the largest single-institution clinical series examining patients with PDTB in the English literature.
CONCLUSION : this literature review confirms the existence of neurocognitive markers of suicide vulnerability in elderly people.
CONCLUSION : This longitudinal study showed that the aging process was associated with decline of renal function in the healthy elderly.
CONCLUSION : This mean value may provide a useful database for evaluating anthropometric parameters and physical fitness in elderly Japanese subjects.
CONCLUSION : This meta-analysis and systematic review suggests that exercise interventions positively influence cognitive function in patients with chronic diseases.
CONCLUSION : This meta-analysis provides evidence that Cerebrolysin has an overall beneficial effect and a favorable benefit-risk ratio in patients with mild-to-moderate AD.
CONCLUSION : This meta-analysis suggested that mirodenafil is effective and well-tolerated therapy for ED.
CONCLUSION : This meta-analysis supports the idea that the MTHFR C677T genotype is associated with risk of ALL in Caucasians.
CONCLUSION : This method delivers the p38 inhibitor VX-745 in sufficient quantities for preclinical studies to rescue the aging phenotype in Werner syndrome.
CONCLUSION : This multifactorial intervention among octogenarians , including individuals with cognitive impairment or comorbidities , did not result in a reduction in falls.
CONCLUSION : This national cohort of well-characterized Spanish-speaking elders provides descriptive data on cognitive performance , an important tool for clinical and research efforts.
CONCLUSION : This need-based intervention appears promising for improving the behaviour of a considerable proportion of patients.
CONCLUSION : This new discovery highlights the importance of REV-ERB-ALPHA1 in obesity and provides evidence for the connection between our biological clock and obesity-related traits.
CONCLUSION : This new scale captures views on two common trade-offs in health care.
CONCLUSION : This novel classification of the G8 score contributes to prompt identification of patients with poor prognosis and improved the prognostic value of ECOG-PS.
CONCLUSION : This paper details our protocol for a population-based study in collaboration with local Aboriginal community organizations.
CONCLUSION : This paper provides a description of the burden of the major cancers in Abruzzo and Molise until @number@
CONCLUSION : This paper provides consumer perspectives to inform aged care policy , practice and research in Australia.
CONCLUSION : This pattern suggests that the AD pathological process coordinates SWM demyelination in the temporal and paralimbic regions , but not elsewhere.
CONCLUSION : This @percent@ polyacrylamide hydrogel offers promise as a long-lasting soft tissue filler.
CONCLUSION : This pilot study establishes a relationship between the OHAT and Fried Frailty Criteria in a population of frail elderly.
CONCLUSION : This pilot study has helped to inform ways to better train and support FPs in conducting DMCAs.
CONCLUSION : This population-based study demonstrated that the gain in life expectancy with RP compared with the general population in Denmark is minimal.
CONCLUSION : This population-based study reinforces the importance of self-reported health status as a predictor for OS.
CONCLUSION : This population-based study suggests that COPD is associated with increased odds of having MCI and its subtypes.
CONCLUSION : This population benefits from the clinical application of supplementation with preparations containing Zn , added calories , protein , and other trace elements.
CONCLUSION : This preliminary examination of the CLSA Tracking cognitive measures lends support to their use in large studies of aging.
CONCLUSION : This preliminary report suggests that the APOE ε4 allele is associated with increased risk of gait speed decline and disability in older men.
CONCLUSION : this preliminary study shows that the MSRA questionnaire is predictive of sarcopenia and can be suggested as prescreening instrument to detect this condition.
CONCLUSION : This present study supports the efficacy and effectiveness of the support group for persons with mild dementia in Chinese society.
CONCLUSION : This proposed M-health system could assist elderly outpatients ' homecare in preventing medication errors and improving their medication safety.
CONCLUSION : This prospective cohort study suggests a significant association between change in leisure and social activities during old age and risk of dementia.
CONCLUSION : This results can be translated into clinic as higher numbers of AHSCT candidates over age @number@
CONCLUSION : This review article outlines the current status of the most relevant cardiac biomarkers related to AHF.
CONCLUSION : This review highlighted the key contextual challenges for AMS in LTCFs.
CONCLUSION : This review highlights the limited number of studies examining medicines management interventions for people with dementia.
CONCLUSION : This review provides evidence of an association between somatic comorbidities and multifaceted LOAD progression.
CONCLUSION : This review provides the current status of disaster-health research following the Great East Japan Earthquake.
CONCLUSION : This review provides the first quantitative analysis of the effect of study design on age-related differences in muscle fatigue.
CONCLUSION : This short-term intensive program may be beneficial to women at risk of mobility limitations.
CONCLUSION : This study allows us to conclude that older age is associated with a later onset of asthma and a longer duration of symptoms.
CONCLUSION : This study confirmed good tolerance and excellent efficacy of this first one medical device used at home.
CONCLUSION : This study could find no link between CAD and traditional risk factors , except for hypertension.
CONCLUSION : This study demonstrated that allogeneic HDF can produce an improvement in aesthetic appearance with minimal adverse events and warrants further investigation and development.
CONCLUSION : This study demonstrated that an intimate connection existed between γ-H2AX expression and EBV infection in NPC both in vivo and in vitro.
CONCLUSION : This study demonstrated that Klotho attenuated cellular apoptosis and senescence in vascular cells via mitogen-activated kinase kinase and extracellular signal-regulated kinase pathways.
CONCLUSION : This study demonstrated the positive filling effect of Fillerina® in decreasing the clinical signs of skin aging and in improving the face volumes.
CONCLUSION : This study demonstrates striking increases in depression diagnosis and treatment with antidepressant medications , but disparities persist without clear evidence about underlying mechanisms.
CONCLUSION : This study demonstrates that aging enhances skin maceration.
CONCLUSION : This study documents significant sex differences in the pattern of change in QUS measures over childhood and adolescence.
CONCLUSION : This study does not suggest a major effect of fish / fish oil or n-3 fatty acids on the risk of AF.
CONCLUSION : This study emphasizes the importance of evaluating bone mineralization in individuals with PWS and the beneficial effects of prolonged treatment with growth hormone.
CONCLUSION : This study established the feasibility of making the aMCI designation in the community and identified some likely sources of error.
CONCLUSION : This study evaluated the differences in cortical and trabecular bone parameters in each different region of the distal humerus.
CONCLUSION : This study examines the role of meaning in life in stroke experience from an existential perspective.
CONCLUSION : This study found an association between sensory impairment and suicide ideation in elderly individuals.
CONCLUSION : this study found an inverse association between alcohol consumption and physical limitations.
CONCLUSION : This study found no evidence that psychosocial resources buffer against functional decline and mortality in frail older adults.
CONCLUSION : This study found no evidence to suggest envelope colour has an effect on response to participate in a trial or questionnaire returns.
CONCLUSION : This study found that influences on coping were multifactorial and moderated by age.
CONCLUSION : This study found that more than @percent@ of the older adults sampled did not meet current daily dairy intake recommendations.
CONCLUSION : This study found that the rates of overweight in elderly Chinese increased overall between @number@ and @number@
CONCLUSION : This study has assessed a high prevalence of subjects aged @number@ and over hospitalized in the Department of Dermatology in Bamako.
CONCLUSION : This study has provided standardization of MRI acquisition and imaging marker collection across different Italian clinical units and equipment.
CONCLUSION : This study has shown that PMMA microsphere injection is a safe subdermal technique in the correction of infraorbital rhytids.
CONCLUSION : This study highlights JAD as a promising compound for investigating GAG structure-function relationships and for applications in skin cosmetic / corrective strategies.
CONCLUSION : This study highlights the association between greater neighborhood cohesion and lower risk of overall self-neglect in Chinese-American older adults.
CONCLUSION : This study highlights the dynamic nature of social networks in later-life Chinese immigrants.
CONCLUSION : This study highlights the importance of arousal and contextual information in modulating emotional memory in younger and older adults.
CONCLUSION : This study highlights the need for an improvement in the evidence-base regarding the best way to assess office BP for correct hypertension diagnosis.
CONCLUSION : This study indicates that Lp-X induces foam cell formation in human-derived macrophages.
CONCLUSION : This study is the first report that use of antiseptic mouthwashes for more than @number@ weeks could worsen xerostomia in patients taking polypharmacy.
CONCLUSION : This study is the first to establish the emergence of gender and racial / ethnic disparities in sleep duration during early adulthood.
CONCLUSION : This study points to the importance of excessive polypharmacy as an indicator for mortality in elderly persons.
CONCLUSION : This study provides additional data regarding the functioning and adaptations of the postural control system during pregnancy.
CONCLUSION : This study provides a descriptive epidemiological collection of the health conditions of older in-patients.
CONCLUSION : This study provides a framework for further advanced studies in establishing new methodologies or modifying stimulation parameters.
CONCLUSION : This study provides evidence for the validity of LSA in two Latin American populations.
CONCLUSION : This study provides evidence that n-3 PUFAs activate cognitive function in the elderly.
CONCLUSION : This study provides evidence that the FaB-FC has sound psychometric properties.
CONCLUSION : This study provides further empirical support for the conceptual separation of emotional and social loneliness.
CONCLUSION : This study provides further evidence that pre-diabetes may not directly contribute to the development of kidney disease.
CONCLUSION : This study provides insights beyond publicly available documents to explore the processes that underlie simple statements of health system objectives.
CONCLUSION : This study provides reference data for OC and PINP in healthy Caucasian children from a Central European population.
CONCLUSION : This study provides significant contributions to existing knowledge about hospice enrollment and disenrollment patterns.
CONCLUSION : This study reaffirmed that disability is the risk factor of depression , using longitudinal data.
CONCLUSION : This study reported reference data with percentiles for a new promising method for reliably testing RT.
CONCLUSION : This study revealed interethnic differences among older Asian Americans ' contact with physicians.
CONCLUSION : This study's findings suggest that sensory impairment in older adults can increase their probability of experiencing depressive and anxiety syndrome.
CONCLUSION : This study showed a significant increase of cognitive scores over time.
CONCLUSION : This study showed that creative , evidence-based educational programming can improve staff knowledge about urinary incontinence and change staff attitudes toward urinary incontinence.
CONCLUSION : This study showed that renal tubular damage was common and was an independent risk factor for renal deterioration in the Japanese population.
CONCLUSION : This study showed that shoulder proprioception was impaired in patients with SIS.
CONCLUSION : This study showed that the most prominent change after the 800-line MFU-V treatments in Asians was the significant submental lift at @number@ days.
CONCLUSION : This study showed that the multicomponent cognitive behavioral intervention improved control beliefs , self-efficacy , outcome expectations , and social interactions.
CONCLUSION : This study shows that alfuzosin @number@ mg is effective and well tolerated in patients with BPH / LUTS with or without antihypertensive medications.
CONCLUSION : This study shows the convenience of the MP-BV in terms of ease of use and of export of measured data.
CONCLUSION : This study shows the importance of interprofessional teamwork in primary care settings to facilitate linkages of older patients to CSSs.
CONCLUSION : This study suggested that the optimal criteria for sarcopenia should be selected according to BMI in community-dwelling older men.
CONCLUSION : This study suggests frequent non-adherence to physician recommendations for surveillance colonoscopy in community practice.
Conclusion : This study suggests normal patterns of oromyofacial system in most functionally independent elderly individuals.
CONCLUSION : This study suggests suboptimal treatment of those not in glycemic control ( HbA1c ≥ @percent@ , @number@ mmoL / mol ) .
Conclusion : This study suggests that childhood abuse is associated with increased risk of elder abuse among Chinese adult children in the United States.
Conclusion : This study suggests that self-neglect and its phenotypes are significantly associated with suicidal ideation among Chinese older adults.
CONCLUSION : This study suggests that the internal structure of subcutaneous tissue , as observed by ultrasonography , is related to wrinkle depth.
CONCLUSION : This study suggests that the midfacial fat pad is thickened in the elderly and that there is a site specificity in the alteration.
CONCLUSION : This study supports previous work on intrinsic and extrinsic barriers to older people with mental health problems accessing mental health services.
CONCLUSION : This study supports the CRAWS-CV as a valid measure of wandering in community-dwelling elders with dementia in northern Taiwan.
CONCLUSION : This survey was a first attempt to estimate the use of antipsychotics in care homes.
CONCLUSION : This systematic review and meta-analysis provided evidence for person-centered care in clinical practice for people with dementia.
CONCLUSION : This systematic review positions microneedling as a safe and effective therapeutic option for the treatment of scars and wrinkles.
CONCLUSION : This systematic review supported the positive effects of relaxation interventions on depression and anxiety among older adults.
CONCLUSION : This trial offers insight regarding design for future interventions that may allow greater flexibility in length of delivery beyond our study's 12-week timeframe.
CONCLUSION : This updated method allows efficient analysis of folate forms in human plasma and tissues without the loss of sensitivity or precision.
CONCLUSION : This was the first assessment of the relation between the grade of conjunctivochalasis and pinguecula in a large consecutive series of patients.
CONCLUSION : This work highlights the importance of adequate protein intake as a potentially modifiable risk factor for fall prevention in older adults.
CONCLUSION : Though correlated with age , the etiology of elevated inflammatory markers remains incompletely defined.
CONCLUSION : TIMP-1 is independently associated with myocardial diastolic dysfunction in patients with Type @number@ diabetes mellitus.
CONCLUSION : To accurately assess gender differences in CKD progression rates , gender differences in age-related decline in GFR should be considered.
CONCLUSION : To date , there are few dedicated investigations of risk factors for OS , especially smoking.
CONCLUSION : Tooth loss was associated with greater risk of functional disability in community-dwelling elderly Japanese.
CONCLUSION : To our knowledge , this is the largest series of TLHIs in DISH-altered spines in literature.
CONCLUSION : Total and free PSA levels in the serum are altered by prostate massage , rigid cystoscopy , TRUS-guided prostate biopsy , and TURP.
CONCLUSION : Totally @percent@ of treated acromegalic patients had a high IGF1 and normal GH level.
CONCLUSION : TPMT is a stable enzyme , and its assay is not affected by age , gender , race or co-morbidity.
CONCLUSION : Translating an existing instrument is complex and time-consuming , but a rigorous approach is necessary to obtain instrument equivalence.
CONCLUSION : Transvenous extraction of superfluous leads is highly successful , with few procedural complications.
CONCLUSION : Trauma in the elderly is a serious public health problem , with a tendency to progressive worsening with population aging.
CONCLUSION : Treatment costs of AAP increase in parallel with aging , and the costs are generally higher with routine CT compared to selective imaging.
CONCLUSION : Treatment of hearing loss with CIs results in a significant reduction in loneliness symptoms.
CONCLUSION : Treatment of moderate-to-severe CFL with onabotulinumtoxinA was effective and well tolerated.
CONCLUSION : Treatments with polyalkylimide have been reported to give rise to complications years after treatment.
CONCLUSION : TRIM improved communication about medications and accuracy of documentation.
CONCLUSION : TRPV1 receptors could prove to become vital to target disorders of vascular origin and neurodegeneration.
CONCLUSION : Tsimane men show positive associations between testosterone and cognitive performance , particularly for recall and visual scanning , despite higher immune burden.
CONCLUSION : TTC is associated with intensification of NO signaling relative to that in normal age-matched females.
CONCLUSION : TU could significantly increase the serum testosterone level and improve the clinical symptoms of LOH patients without inducing serious adverse reactions.
CONCLUSION : TUG1 modulated lens epithelial cell apoptosis through miR-421 / caspase-3 axis.
CONCLUSION : Twelve months after surgery , risk factors for overall and objective treatment failure were similar in women undergoing retropubic and transobturator sling procedures.
CONCLUSION : Twelve weeks of BodyBalance training is effective at improving certain balance and functional based tasks in healthy older adults.
CONCLUSION : Twenty-unit HBTX-A provided optimal improvement in glabellar lines , and its use might minimize injection frequency while maintaining acceptable safety.
CONCLUSION : T , W , L and M show highly differentiated growth patterns.
CONCLUSION : Two cases of XP with neurologic degeneration are reported.
CONCLUSION : Two thirds of the study participants had CVD and half were at risk of undernutrition.
CONCLUSION : TXS promotes tumor growth in-vivo in NSCLC , an effect which is at least partly mediated through increased tumor angiogenesis.
CONCLUSION : Type D personality was independently associated with all-cause and cardiac mortality in younger ICD patients but not in older patients.
Conclusion : UI in older adults is associated with incident parkinsonism and may identify older adults at risk for accumulating PD brain pathology.
CONCLUSION : UI was associated with an excess of fat mass and poor PF , especially upper-body flexibility.
CONCLUSION : Ultimately , elucidating factors associated with increased caregiver burden and poorer QoL is pertinent for identifying at-risk families and developing targeted interventions.
CONCLUSION : Ultrasonography ( US ) has improved safety and effectiveness of port system placements.
CONCLUSION : Ultrastructural findings of the osteoarthritic articular cartilage were much different from the ageing non-osteoarthritic cartilage.
CONCLUSION : under-reporting was more frequent among older persons with higher percentage of body fat in both methods of assessment of food intake.
CONCLUSION : understanding age discrimination is vital if we are to develop appropriate policies and to target future interventions effectively.
CONCLUSION : Underutilization of services has been linked to increased mortality in African Americans.
CONCLUSION : Unenhanced brain MRI of long-term survivors of childhood cancer detected a substantial number of intracranial neoplasms.
CONCLUSION : Unfavourable SES and lifestyles associate with increased risk of obesity , especially in middle-aged men.
CONCLUSION : Unipedal stance time was the physical performance measure that was most strongly associated with LS.
CONCLUSION : Unmet ADL needs are prevalent among older adults with family caregivers.
CONCLUSION : Unrealistic sleep beliefs are widespread , with healthy sleep usually being mistakenly conceptualized as unbroken , even in older adults.
CONCLUSION : Urbanization has brought Bedouins towards poverty and undernutrition , with older children suffering more severe consequences in comparison with preschool-age children.
CONCLUSION : Urinary incontinence and depressive symptoms were independent associated factors for falls among older men living in the retirement communities.
CONCLUSION : U.S. Chinese older adults suffered considerable discrimination , but tended to have passive responses to unfair treatment.
CONCLUSION : Use of adhesive tape can be an effective temporary measure for relief of symptoms of inturned upper eyelid eyelashes.
CONCLUSION : Use of bladder antimuscarinics was more common in older adults with impaired cognition than in those with normal cognition.
CONCLUSION : Use of dopamine agonists , including pramipexole , was associated with non-significantly increased risks of heart failure in this population-based study in Taiwan.
CONCLUSION : Using MOT as means for measuring attentional performance , we have demonstrated an age-related attentional decline.
CONCLUSION : Using SPM , we found not only similar areas of brain , but also sex-specific cerebral areas of age-associated changes of FDG uptake.
CONCLUSION : Using these analytical methods it is possible to detect different patterns of cognitive change with age.
CONCLUSION : UVB radiation could cause increased 5hmC and TET expression , which might become a novel biomarker in UVB-related skin aging.
CONCLUSION : Vacuoles in the basement membrane are a normal feature of adult human retinal capillaries and do not indicate disease.
CONCLUSION : Variant factors are associated with postoperative ascites for hepatocellular carcinoma and the scoring system established can predict the ascites after hepatectomy accurately.
CONCLUSION : Variations among different normal ranges were dependent on the vendor used , LV end-diastolic diameter and age.
CONCLUSION : Vascular brain pathology is associated with rate of cognitive decline after adjusting for level of AD pathology.
CONCLUSION : VATS lobectomy for early NSCLC is associated with less acute inflammatory responses and less immunosuppression when compared with OT.
CONCLUSION : VAVG , 6MWD , and TUG correlated with LAF reflex loop function observed among those with impaired functioning of the SAF reflex loop.
CONCLUSION : VCD-Lite is a viable option for vulnerable adults with NDMM.
CONCLUSION : Vegetarians were at lower risk of cataract than were meat eaters in this cohort of health-conscious British residents.
CONCLUSION : VEGF may be associated with certain personality factors.
CONCLUSION : Vertebral height decreased with age , but spinal canal diameter did not change in patients with either LSS or HCD.
CONCLUSION : Very elderly patients represent a high-risk cohort , with significantly increased in-hospital mortality and complication rates after PCI.
CONCLUSION : VFA was the strongest predictor of plasma LECT2 that is a potential biomarker linking visceral obesity to dyslipidemia.
CONCLUSION : Video gaming in rehabilitation is widely used by clinicians.
CONCLUSION : Violation of tissue renewal is a major cause of carcinogenesis in people older than @number@ years old.
CONCLUSION : Vitamin D insufficiency was associated with subjective cognitive complaint in the studied cohort of geriatric patients.
CONCLUSION : Vitreoretinal changes found in this case might have been partially because of the premature aging associated with Werner syndrome.
CONCLUSION : VOR gain was stable until age @number@ years and thereafter dropped.
CONCLUSION : VYC-15L was safe and effective for lip and perioral enhancement , with treatment effects lasting through @number@ year.
CONCLUSION : VYC-17.5L is effective and well tolerated for the treatment of moderate to severe NLFs for @number@ year.
CONCLUSION : Walking interventions targeting older women should incorporate local destinations.
CONCLUSION : WC had comparable power with VFA to identify elderly people who are at risk for MetS.
CONCLUSION : Weaker circadian activity rhythm patterns are associated with worse cognitive function , especially executive function , in older women without dementia.
CONCLUSION : We certainly need more evidence.
CONCLUSION : We concluded that reproductive factors discriminate the three different menopausal age groups for this study population.
CONCLUSION : We conclude that a predominantly biomedical perspective on human development diminishes patient-centered care within a socially contextualized , individual perspective.
CONCLUSION : We conclude that the age may affects the response of the proximal esophagus to wet swallows.
CONCLUSION : We conclude that the incidence of repeat vertebral augmentation is rather high.
CONCLUSION : We conclude that the prevalence of sexual symptoms in older males is high and important.
CONCLUSION : We conclude that this GFU is cost-effective and deserves to be considered for implementation in other hospitals.
CONCLUSION : We confirm for seniors living in the community that women have a higher risk of hip fracture than men.
CONCLUSION : We confirm that memory and language function tests discriminate between FTLD and AD.
CONCLUSION : We demonstrated age-dependent linear decrease of pneumococcal antigen excretion into urine in healthy children.
CONCLUSION : We demonstrated a larger tissue volume with subtle BBB leakage in patients with cSVD than in controls.
CONCLUSION : We demonstrated good diagnostic accuracy and convergent validity for the online self-test of cognitive function.
CONCLUSION : We demonstrate the feasibility of assessing brain activity underlying declarative memory using a natural stimulation paradigm with high ecological validity.
CONCLUSION : We describe a novel assay for TL assessment using the Luminex platform.
CONCLUSION : We described the normal characteristics and aging patterns of scalp hair in a Korean population.
CONCLUSION : We did not find any effect of the PReCaP on ADL and IADL.
CONCLUSION : We did not observe associations among metabolic syndrome , body composition , and functionality variables.
CONCLUSION : We do not think that CC-EMG findings could be used efficiently as a predictor of ageing.
CONCLUSION : We established the RIs for serum HE4 , CA125 and ROMA with ECLIA in healthy Chinese female.
CONCLUSION : We estimate the direct costs per TB patient to be €10 , 509.
CONCLUSION : We found a high prevalence of vitamin D deficiency among elderly men despite their high sun exposure during the summer months.
CONCLUSION : We found a negative association of FTSS with global cognitive performance.
CONCLUSION : We found a stronger correlation between RDW and EF , proBNP and FC in the younger patients compared the elderly group.
CONCLUSION : We found executive dysfunction to be a powerful stroke risk factor among cognitively normal subjects.
CONCLUSION : We found no difference in FMD regardless of the baseline brachial artery diameter used in children and adults.
CONCLUSION : We found no evidence that spectacles promote decline in uncorrected vision with aging among children.
CONCLUSION : We found that age ≥70yo was an independent risk factor for DWLSTs for patients in the ICU , but not for their mortality.
CONCLUSION : We found that depressive symptoms are common among patients referred for a dementia assessment in specialist health care.
CONCLUSION : We found that the abuse and mistreatment are present in the everyday life of many seniors and are a difficult subject to approach.
CONCLUSION : We found the Beneslider to be an effective appliance that enables bodily distalization in adequate treatment time.
CONCLUSION : We generated new zebrafish models for a human premature aging disorder , and further demonstrated the utility for studying laminopathies.
CONCLUSION : We have confirmed , in a single population , a changing pattern in the aetiology of syncope as a person ages.
CONCLUSION : We have developed age-specific normal values for performance on the ISWT in a healthy British population.
CONCLUSION : We have identified FGD5 as a novel genetic regulator of vascular pruning by activation of endothelial cell-targeted apoptosis.
CONCLUSION : We have reported a set of characteristics that are highly prevalent in OS patients.
CONCLUSION : We hypothesize that treatment with bosentan , an endothelin-1 receptor antagonist , improves maximum exercise capacity and functional capacity in adult Fontan patients.
CONCLUSION : We identified and replicated @number@ genes that were associated with circulating interleukin-6 levels.
CONCLUSION : We identified novel epigenetic loci associated with Hcy levels , of which specific role needs to be further validated.
CONCLUSION : Weight bearing on the lower extremities is significantly reduced when the upper extremities are supported during walking with an FWW-AR.
CONCLUSION : Weight cycling and weight loss predict impending mobility disability and mortality in old age , underscoring the prognostic importance of weight history.
CONCLUSION : Weight loss is a predictor of death in advanced dementia.
Conclusion We must rigorously evaluate interventions to deliver more patient-focused care to an increasingly frail nursing home population.
CONCLUSION : We observed a good clinical outcome.
CONCLUSION : We observed a significant decline in standing balance among older women who developed UI symptoms.
CONCLUSION : We observed a substantially and significantly lower mortality in participants in the Tour de France , compared with the general male population.
CONCLUSION : We observed in a cohort of healthy older adults that compensatory saccade amplitude and latency were associated with tandem stance performance.
CONCLUSION : We observed that particularly lethal combination is older age , perforation with peritonitis and advanced stage of the cancer.
CONCLUSION : We present CMR-derived LV reference values.
CONCLUSION : We presented a nomogram of age-specific AMH values in a healthy cohort of Iranian men.
CONCLUSION : We present normal values of CN and FN diameters on 3D-CISS at 3T.
CONCLUSION : We propose that low-dose clomiphene should be the first step in the treatment of adolescent dysfunctional bleeding ( DUB ) .
CONCLUSION : We propose that rapamycin at micro-dose can be developed into an antiaging agent with a novel mechanism.
CONCLUSION : We provide evidence of a strong posttranscriptional regulation of ABCA1 and ABCG1 expression in human atherosclerotic plaques from hypercholesterolemic patients.
CONCLUSION : We provide evidence that induction of neurogenesis is integral to the therapeutic effects of fluoxetine in NHPs.
CONCLUSION : We provide the first report that LTL is strongly associated with PCOS.
CONCLUSION : We report significant age-related differences in visual scanning that are specific to faces.
CONCLUSION : We show a significant impact of 123I-FP-CIT SPECT on diagnoses , even in cases of definite parkinsonism or probable DLB.
CONCLUSION : We showed that probiotic supplements may have a positive effect on bowel movements among orthopedic rehabilitation elderly patients.
CONCLUSION : We suggest that the chronic inflammatory burden observed in people with chronic periodontitis could represent the driver of telomere shortening.
CONCLUSION : When etched with @percent@ , @percent@ , or @percent@ hydrofluoric acid , the ceramic tested showed stable resin adhesion after long-term aging.
Conclusion When measuring hs-cTnT , careful assessments are needed in elderly subjects.
CONCLUSION : When Y-TZP ceramic is bonded to dentin , the weakest interface is that between dentin and resin cement.
CONCLUSION : Whereas hearing loss was strongly related to target-word recognition , the effect of aging was only weakly related to task performance.
CONCLUSION : While protein intake was higher than current recommendations , it failed to achieve the values reported as necessary to prevent sarcopenia.
CONCLUSION : while retirement was associated with a greater volume of PA , most older adults do not meet current recommended PA guidelines.
CONCLUSION : Widowed elderly adults experienced more depressive symptoms than did married.
CONCLUSION : Widowhood augments the effect of negative life events on dementia incidence and negative life events specifically increase the risk for vascular dementia.
CONCLUSION : With a high incidence in healthy individuals , SNs occur in discs at all degrees of degeneration.
CONCLUSION : With improved knowledge the staff could offer the elderly more individualised meals.
CONCLUSION : Within cortical lamina , distance measures may be of value in testing PET tracers for their anatomic selectivity.
CONCLUSION : With the age increasing , PPM implantation might be easier to result in infection.
CONCLUSION : With the novel probe , statistically significant differences between overlapping classes in score plots can be confirmed by calculating intra-model distances.
CONCLUSION : With the present study , we have demonstrated that the processing-speed hypothesis in aging extends to older adult patients with CVD.
CONCLUSION : Women were less likely to decline in frailty status than men.
CONCLUSION : Women with more negative attitudes towards the menopause in general report more symptoms during the menopausal transition.
CONCLUSION : Work-related psychosocial stress may increase the risk of T2DM only amongst women in their early 60s.
CONCLUSION : Worse neighborhood characteristics are associated with adiposity , hyperglycemia , and low HDL.
CONCLUSION : Worse performance on the TUG test was only the patient-related predictor of distress among the variables examined as contributors to the higher NIoC.
CONCLUSION : Worthlessness may be independently associated with all-cause mortality in Chinese elderly men.
CONCLUSION : Xerostomia is associated with old age and poor appetite in patients on chronic HD.
CONCLUSION : Yoga significantly reduced the depressive symptoms of elderly participants and improved their quality of sleep after @number@ months.
CONCLUSION : Young adults are the caregivers of tomorrow.
CONCLUSION : Young maternal age at first birth might be associated with increased BMI.
CONCLUSION : Young people have higher ECD.
CONCLUSION : Young women who less frequently attend school or who drop out are more likely to have an age-disparate relationship.
CONCLUSION : Zinc deficiency induced inflammatory response in part by eliciting aberrant immune cell activation and altered promoter methylation.
Conclusive evidence about adverse cardiovascular , metabolic , and cognitive consequences of subclinical hypothyroidism in the elderly remains elusive.
Conclusively , almost all of the measured Greek adolescents were exposed to SHS , even when their parents were non-smokers.
Conclusively during aging , interventions , which distinctively consider the changing level of individual hormones , shall provide potent options in maintaining optimal immune functions.
Conclusively , our results suggest an altered phonetic processing at the perceptual level during physiological aging.
Conclusively , the regulatory effects of insulin on endothelial senescence were modulated by the glucose environment.
Conclusively , vertebrate regeneration declines with age with the loss of stem / progenitor cell function.
CONCLUSÕES : Idosos com doenças específicas têm fatores de risco para polifarmácia modificáveis por ações que visem o uso racional de medicamentos.
CONCLUSÕES : Infecções oportunistas e doenças do envelhecimento foram as causas mais frequentes de óbito , imprimindo carga múltipla de doenças aos serviços de saúde.
CONCLUSÕES : O cuidado informal é a principal fonte de ajuda domiciliar aos idosos com limitações funcionais.
Concluson : Lower sodium intake was associated with worse cognitive function in older community-dwelling adults.
Concomitant chemotherapy consisting of cisplatin or nedaplatin and 5-fluorouracil with RT was performed in @number@ patients.
Concomitant improvement in PI may be important to consider when measuring apathy or depression interventions in PD.
Concomitant infections were found , HPV high-risk types were involved in half of these cases , representing a higher risk.
Concomitantly , protein kinase C zeta ( PKCζ ) protein levels and c-Jun N-terminal kinase ( JNK ) phosphorylation were reduced.
Concomitantly , the actors have different ideas on how a flexible transition to retirement could be organised , with country differences being more pronounced here.
Concomitantly , the FVR also decreased significantly in both sessions , this reduction being more evident in S80% ( P < 0·05 ) .
Concomitantly , the ROS level in Gnaq-SY5Y cells was significantly decreased whether the cells were subject to or not to H2O2 treatment.
Concomitantly , we will discuss how targeting this dyshomeostasis offers an effective and novel therapeutic approach.
\ "Concomitant \ " therapy is more effective and is simpler than \ "sequential \ " therapy.
Concomitant treatment with nonpermanent fillers , as well as any significant adverse events , was noted as well.
Concomitant use of potentially harmful interacting drugs generally increased with age and with increasing use of NSAIDs.
Concomitant with aberrant matrix destruction are alterations in levels of reactive oxygen species ( ROS ) generating and detoxification systems.
Concomitant with the anticipated release of these vaccines , vaccine allocation strategies for dengue-endemic countries in Southeast Asia and Latin America are currently under development.
Concordance correlation coefficients were generally high except for WHR.
Concordance of parameters using uAm compared to sAm was assessed.
Concordance rates for PD or parkinsonism were @percent@ for monozygotic and @percent@ for same-sexed dizygotic twin pairs , with a heritability estimate of @percent@.
Concordance rates for PD or parkinsonism were somewhat higher but the heritability estimate was nonsignificant.
Concordance rates for PD were @percent@ for monozygotic and @percent@ for same-sexed dizygotic twin pairs , with a heritability estimate of @percent@.
Concordance rates for PD were @percent@ for monozygotic and same-sexed dizygotic twin pairs and @number@ for opposite-sexed twin pairs.
Concordance was lacking between the other genes that were studied.
Concordance with the \ "gold standard \ " is highest with @percent@ ethanol and acceptable with FOBT.
Concordant data was observed at 2-year follow-up.
Concordantly , DNA-PKcs inhibition robustly induced apoptosis in MSH3-mutant cell lines in vitro and displayed remarkable single-agent efficacy against MSH3-mutant tumors in vivo.
Concretely , the label-free method proposed is based on the application of a constant-current chronopotentiometric stripping ( CPS ) analysis at Hg-containing electrodes.
Concurrent assessment of various vessels from the same subjects is unavailable in the literature.
Concurrent CHF and COPD frequently occur , especially in with advancing age.
Concurrent contrast radiography is helpful to verify the location and degree of obstruction , and to reveal the cause of the obstruction.
Concurrent data collection and analysis , data saturation , and a constant comparative method guided the research.
Concurrent evaluation allows the prospective exploration of the complex interactions among health determinants as well as the comparative effectiveness of novel biomarkers in predicting health.
Concurrent loss of LKB1 and AMPK activity in articular chondrocytes is associated with OA , aging and biomechanical injury.
Concurrently , age-related changes in neuroendocrine response also contribute to the declining reproductive function.
Concurrently , CD4 monitoring has remained stable in recent years , whereas HIV viral load monitoring , although varied among the sites , is increasing.
Concurrently , mice develop delayed deficits in LTP and cognition.
Concurrently , our data reveal that astrocytes display a reduced expression of neuronal support genes and genes involved in neuronal communication.
Concurrently , sarcopenia is defined according to the recent definitions of low muscle mass proposed by the Foundation for the National Institutes of Health-Sarcopenia Project.
Concurrently , the expression of the epithelial markers , E-cadherin and keratin @number@ and @number@ was attenuated.
Concurrently , there is a progressive decline in self-recognition.
Concurrently , TNF-α regulated a broad gene network with cobinding activities for cREL , ΔNp63α and TAp73 observed upon array profiling and reverse transcription-PCR.
Concurrent validity and inter-rater reliability of the COPM and content validity of both the COPM and SIGA appear to be good.
Concurrent validity correlation coefficients of the FLSQ domain scores with the associated concurrent measures were acceptable ( range : r = @number@.40-0.70 ) .
Concurrent validity was assessed against the FES-I using Spearman's rho.
Concurrent validity was assessed by comparing EFAT2 with the Barthel Index.
Concurrent with the reduction of the immunoproteasome , rapamycin reduced two important inflammatory response pathways , the NF-κB and Stat3 signaling.
Conditional analyses indicate GWAS signals on rDR level were driven by APOE , whereas signals on IR change were driven by TOMM40.
Conditional analysis of rs976683 provided no evidence of additional independent associations at the locus.
Conditional analysis revealed that rs2732703 accounted for association signals in the entire 100-kilobase region that includes MAPT.
Conditional genetic removal of these receptors enhanced memory in aging hAPP mice.
Conditional logistic regression analysis for injurious RTC was performed with adjustment for occupation and number of medications.
Conditional logistic regression analysis in @number@ dementia-discordant twin pairs led to an attenuated midlife BMI-dementia association.
Conditional logistic regression analysis was used to compute the odds ratio ( OR ) and @percent@ confidence interval ( CI ) .
Conditional logistic regression ( dementia-discordant pairs ) and mixed effects models ( dementia-concordant pairs ) were used in twin analyses.
Conditional logistic regression models adjusted for demographics and baseline vascular risk factors.
Conditional logistic regression model stratified on matched case-control sets was performed to assess mortality risk , after controlling for other risk factors.
Conditional logistic regression models were used to estimate matched odds ratios for incident diabetes according to categories of both forms of OC measured by ELISAs.
Conditional logistic regression model was used to estimate odds ratio ( OR ) associated with current use of BPs after adjusting for several covariates.
Conditional logistic regression was used to identify factors associated with medication errors.
Conditional Wnt16 inactivation revealed that osteoblast-lineage cells are the principal source of WNT16 , and its targeted deletion in osteoblasts increases fracture susceptibility.
Conditioned ceramics were divided into four groups to receive the resin cements ( Panavia F @number@ Variolink II , RelyX U100 and Maxcem ) .
Conditioned culture medium collected from keratinocytes was used to culture dermal fibroblasts.
Conditioned media from co-cultures of glioma cells with hUCBSC showed reduced angiogenesis as evaluated by in vitro angiogenesis assay using HMEC cells.
Conditioning of LCs in situ by the epidermal microenvironment is likely to be more important.
Condition of large blood vessels was examined by Color-Doppler ultrasound , and carotid and ophthalmic arteries were included.
Conditions associated with the aging process have been diagnosed more frequently among HIV-infected patients , particularly , cardiovascular diseases.
Conditions mimicking pathological cell damage ( serum deprivation ) lead to endothelial apoptosis as evidenced by increased caspase-3 activity.
Conditions most prevalent were bacteriuria ( @percent@ ) , followed by hyperglycemia ( @percent@ ) and anemia ( @percent@ ) .
Conditions that deprive the tissue of energy can kill the oligodendrocytes.
Conditions that render the selection of correct actions difficult require the monitoring of the execution and outcomes of one's own actions.
Condom use rates remained low for participants across age groups.
Conducting TTCC ( including instruction and evaluation ) was accomplished within @number@ minutes for all subjects.
CON failed to increase muscle size ( @percent@ , P = @number@ ) , but significantly improved its strength ( P < 0.05 ) .
Conferences aimed to communicate the diagnosis and prognosis , elicit patient values , assess family understanding , and clarify the goals of treatment.
Confidence alone played little unique role in error correction after controlling for the role of prior knowledge.
Confidence in addressing workplace aggression buffered homecare workers against negative work and health outcomes.
Confidence limits for these estimates are often wide , particularly for APOE-e4 / e4 individuals and for the dementia outcome at @number@ y.
Confirmation of RBD requires polysomnography ( PSG ) .
Confirmation of these results in the general population including women and other ethnic groups is warranted.
Confirmation of this hypothesis could have implications for the prevention and strategic medical management of this form of OA.
Confirmatory factor analyses resulted in acceptable model fit criteria.
Confirmatory factor analyses were conducted to test three competing models and determine the best-fit model for the elderly Chinese sample.
Confirmatory factor analyses were performed on the @number@ symptoms for single factor and bifactor ( physical and affective ) models of symptom reporting.
Confirmatory factor analysis and a technique of structural equation modelling were employed using Amos @number@ to examine the hypothesized relationships between study variables.
Confirmatory factor analysis and hierarchical confirmatory factor analysis were conducted to examine its factorial structure , and its psychometric properties and criterion validity were examined.
Confirmatory factor analysis ( CFA ) was used to examine cross-cultural measurement invariance of the SWFL scale.
Confirmatory factor analysis identified four factors : processing speed , verbal ability , episodic memory , and working memory.
Confirmatory factor analysis indicated that most of the ISEL items loaded strongly ( > 0.45 ) on the original @number@ factors.
Confirmatory factor analysis was then carried out on the scale , and the validity and reliability of the scale assessed.
Confirmatory factor analysis was used on the second half of the sample to evaluate invariance between groups and within groups over @number@ year.
Confirmatory factor analysis was used to determine walkability scores.
Confirmatory factorial analysis showed that the original inventory model , fits with the data collected from Chilean people.
Confirmatory studies used ELISA assays in a separate set of blood samples obtained within a year of the PET scans.
Confirming previous studies demonstrating lowered plasma ghrelin in obesity , ghrelin levels were lower in the obese compared with overweight women.
Confirming prior reports , lower SES ( education and job status ) was positively associated with infection status.
Confirming the outcomes of PD in elderly patients is important as the aging population continues to grow.
Confirming the role of oxidants in numerous pathological conditions such as cancer , the antioxidants developed as therapeutics have been proven ineffective.
Confirming this pathway and its regulation by common genetic variants would provide new strategies for predicting , delaying , and treating neurological diseases.
Conflicting evidence exists on the relationship between blood pressure ( BP ) and insulin-like growth factor-1 ( IGF-1 ) .
CONFLICT OF INTEREST : PWOT is funded by a nonrestrictive research award from General Mills Inc.
Conflicts at all levels of screening and abstraction will be resolved through discussion.
Confluent primary RPE cells were used to test the frequency of endogenous mtDNA damage by quantitative PCR.
Confocal evaluation was blinded to clinical and dermoscopic diagnosis.
Confocal images of the stroma show these microdots mixed with larger keratocyte cells.
Confocal laser scanning microscopy was used to image fluorescence intensity and the area of penetration of fluorescently tagged peptides.
Confocal microscope imaging displayed a limited internalization of nanoparticles into neutrophils.
Confocal microscopy analysis revealed that the dynamic movements of these regulatory proteins in lipid raft microdomains was altered in T cells of aged individuals.
Confocal microscopy revealed TDP-43 aggregations within VGLUT-1-positive axon terminals in a subset of the patients.
Confocal Raman and fluorescence spectroscopy were applied to quantify surface tetragonal-to-monoclinic phase transformation of zirconia and surface stresses in the AMC head.
Confounding by early-life environments , mediating by body size and cardiometabolic measures at @number@ to @number@ years , and effect modification were investigated.
Confounding factors were assessed through a questionnaire.
Confounding in relation to the non-drinker reference category may be of particular importance.
Confounding plays a role , but biologic differences in study populations are unlikely to explain the different risk estimates.
Confusion as to how aggressively such possibly indolent lesions should be treated has led to misunderstandings among patients and medical professionals.
Confusions for sweet were < 1%.
Confusions typically increased monotonically with age.
Congenital aniridia patients showed a normal tear secretion and no dry eye McMonnies scores , except for the group over @number@ years old.
Congenital defects including cleft palate are the serious problem which occupies different sides of society's life.
Congenital defects in nucleotide excision repair ( NER ) lead to distinct cancer-prone and premature aging syndromes.
Congenital hypothyroidism ( CH ) is the most common congenital endocrine disorder , accounting for up to 1 : 1500 newborns per year.
Congestive heart failure ( CHF ) is one of the major causes of death and occurs in more than @number@ patients worldwide.
Congruence between type of learning and recall led to better performance in both groups.
Congruent with this , there has been much research on attachment in older adults over the past three decades.
Conjunction analyses between functional and structural alteration maps were constructed.
Conjunctival swabs were obtained from patients with presumed acute viral conjunctivitis.
Connectedness , maintaining active engagement with life , is crucial to successful aging.
Connecting AOPs to combustion , it is possible to achieve some helpful enlightenment from combustion to analyze , predict and understand AOPs.
Connections involving only left- or only right-lateralized hubs showed positive correlation across subjects , but only for connections sharing a node.
Connection with others is an essential part of our being as humans.
Connective tissues primarily contain collagen and proteoglycans and play an important role in skin ageing.
Connective tissues provide mechanical strength and one of the most demanding tissues in this regard are tendons , which transmit the forces generated by muscles.
Connectivity between these networks even increased with age.
Connectivity decreased with age within networks supporting higher level cognitive functions , that is , within the default mode , cingulo-opercular and fronto-parietal control networks.
Connectivity maps of both left and right seed regions of interest overlapped in the right cerebellum.
Connectivity measures were correlated with memory scores.
Connectivity networks were derived from correlations of cortical thickness and cortical glucose consumption in resting state.
Connectivity strength increased between subcortical nuclei and cortical motor and sensory regions but no changes were found between subcortical components of the circuitry.
Connectivity was also increased with the lateral entorhinal cortex , a relay to memory networks and central node for contextual modulation of olfactory processing.
CONNECT used storytelling , relationship mapping , mentoring , self-monitoring , and feedback to help staff identify communication gaps and practice interaction strategies.
Conscientious individuals felt more mature early in life.
Conscientious leaders should consider transitional care in the context of its wicked nature in order to achieve optimal patient care.
Conscientiousness and good social relationships predicted longer life , whereas subjective well-being was unrelated to mortality risk.
Conscientiousness increased among young adults then leveled off and remained fairly consistent for the rest of the adult life span.
Conscientiousness , neuroticism , and agreeableness were not related to subjective age at older ages.
Conscientiousness reliably predicts health behavioral patterns , and the same is true of executive function.
Conscientiousness remained uniquely related to every physical and mental health outcome.
Conscientiousness significantly moderated the perceived stress-depressive symptom relationship.
Consecutive IQ assessments were available in @number@ patients.
Consecutively eligible patients were included in an inter-rater reliability study between physical therapists.
Consecutive older patients scheduled for elective abdominal surgery with expected LOS longer than @number@ days were enrolled , with a recruitment rate of @percent@.
Consecutive patients with ALS ( @number@ ) and @number@ matched controls participated in standardized neuropsychological assessment and magnetic resonance imaging.
Consensus about health reform requires trust.
Consensus dementia diagnoses were made by an expert panel of clinicians using clinical criteria , and mortality data were obtained from a state registry.
Consensus is needed on future research directions so that collaborative and timely efforts can be made globally to address this modifiable risk factor.
Consensus was achieved if there was at least @percent@ agreement among participants.
Consensus was sought over three rounds using pre-established criteria.
Consent form should include information on the machine , possible postoperative course expected and postoperative complications.
Consenting participants will also contribute blood samples to a research biobank.
Consenting patients at intervention facilities could access telemedicine for acute illness care.
Consenting practice patients at intervention facilities could have patient-to-provider , real-time , or store-and-forward high-intensity telemedicine services to diagnose and treat illnesses.
Consents increased from @number@ to @number@
Consequences of exaggerated inflammatory responses by microglia include the development of cognitive deficits , impaired synaptic plasticity and accelerated neurodegeneration.
Consequent extrasynaptic NMDAR ( eNMDAR ) overstimulation then results in synaptic dysfunction via the aforementioned pathways.
Consequentially , the embryonic and foetal models are attracting much attention for clinical translation into corrective modalities in the adulthood.
Consequently , a 12-week bilateral hopping on the balls of the feet intervention was conducted.
Consequently , abnormal behaviour of these networks due to disease or altered development may predict poor cognitive outcome.
Consequently , Aegis FS containing amorphous calcium phosphate was found to exhibit the lowest microleakage in all surface conditioning procedures.
Consequently , age-correlated increase in dermal mast cell may be proposed to be one of the inflammatory and aging mechanisms.
Consequently , aging and age-related diseases , such as cancer and diabetes are driven by the same genetic determinants.
Consequently , all staff who handle medications should be trained to the level of a medication aide.
Consequently , a needs assessment was performed by using video conferencing software to conduct semi-structured interviews with @number@ LDCs.
Consequently , an increase in double product , an index of myocardial oxygen demand , was more than threefold higher in the BFR condition.
Consequently , an increasing number of HIV-infected people are at risk of non-AIDS-defining cancers that typically occur at older ages.
Consequently , application of CR or CR-mimicking agents may yet offer a promising direction for the extension of healthy human lifespan.
Consequently , appropriate strategies in order to delay visual impairment might help to maintain social ties in old age.
Consequently , approximately two-thirds of study participants were at nutritional risk or malnourished.
Consequently , assessment of LV diastolic function is necessary for both preventing cardiac events and assessing cardiac age.
Consequently , as the lens ages , its transparency falls and the nucleus becomes more rigid , resisting the change in shape necessary for accommodation.
Consequently , as women age , their bodies often become sources of shame , discomfort , and ridicule.
Consequently , blood transfusions have been clinically established to treat severe anemia and thrombocytopenia.
Consequently , both endemic and widely distributed Mediterranean plants growing in the area have unique chemotypes characterized by accumulation of relatively high levels of phytosteroids.
Consequently , cells accumulated an intracellular pool of lactic and pyruvic acids , magnified by the MCT1 inhibitor decreasing further pHi and glycolysis.
Consequently , cellular senescence was induced by high doses of SR in differentiated cells.
Consequently , chlorogenic acid-action mechanisms in preventing platelet activation and thrombus formation were examined.
Consequently , circadian disruption ( e.g. , during aging ) may compromise tissue homeostasis and increase susceptibility to joint damage or disease.
Consequently , cis-regulatory SNPs associated with differential allelic expression are functional candidates for further investigation as disease-causing variants.
Consequently , dental schools should work to incorporate clinical experience into geriatric education to prevent widening an existing gap in older adult oral health care.
Consequently , downregulation of eIF4GII by siRNA decreases translation , cell proliferation and ability to form colonies , as well as induces cellular senescence.
Consequently , dual-task assessment programs that simultaneously address both stability and cognition are important to consider in rehabilitation and benefit healthy aging.
Consequently , dysregulated skeletal renewal and bone loss is a common feature of inflammatory conditions associated with immune activation.
Consequently , estimated K ( Trans ) values varied widely.
Consequently excessive accumulation of age-dependent capsular MDx is expected.
Consequently , exploring the potential mammalian equivalents of yeast-established polarity mechanisms could be the focus for future biogerontological investigations.
Consequently global nurses should recognise those differences and provide culturally appropriate care.
Consequently , growing interest emerged to evaluate new strategies to delay or counteract cognitive decline in aging.
Consequently , H3.3 incorporation and turnover represent an additional layer in the regulation of the chromatin landscape during aging.
Consequently , higher sustained clinical response rates were observed with cadazolid ( @number@ to @percent@ ) than with vancomycin ( @percent@ ) .
Consequently , HIV-infected cohorts are ageing leading to new challenges in the life-long management of this condition.
Consequently , HIV providers are tasked with managing multiple age-related illnesses , within service networks that are historically not designed to care for aging patients.
Consequently , hydrophilic drugs have a smaller apparent volume of distribution ( V ) and lipophilic drugs have an increased V with a prolonged half-life.
Consequently , immune repertoire undergoes continuous dual ( two-way ) resetting : against the physiologic continuous changes of self and against the continuously changing environment.
Consequently , immunosuppressive therapy is no longer limited to young organ recipients.
Consequently , interventions to counteract deteriorations to both muscle mass and possibly muscle quality should be considered in men receiving ADT.
Consequently , in the clinical study of these patients , it is not necessary to request estradiol in the laboratory analyses.
Consequently , it has become increasingly important to establish an effective treatment regimen for elderly patients with advanced non-small-cell lung cancer ( NSCLC ) .
Consequently it is routinely employed in experimental studies to evaluate materials ' performance.
Consequently it is well suited for use in medical classes on these issues , particularly because it is much shorter than a novel or film.
Consequently , its recognition , diagnosis , and management in clinical practice require optimization.
Consequently , its treatment should target the different factors involved , including quantitatively and qualitatively inappropriate food intake and reduced physical activity.
Consequently , it will help care providers to include appropriate spiritual care in the care repertoire of a Muslim care recipient.
Consequently , majority of remained nonsclerosed glomeruli become hypertrophic and some of them sclerotic , too.
Consequently , many more records are created by various healthcare providers when they document the care they provided to the older person.
Consequently , memory CD8 T cells were significantly more sensitive than naïve cells to NE induced changes in gene expressions in vitro.
Consequently , mitochondrial dysfunction plays an important role in the progression of aging and the pathophysiology of many common diseases and off-target drug effects.
Consequently , mitochondrial proteins are under high risk to become damaged.
Consequently , more aged patients than before are receiving diagnoses of impaired renal function and histologic changes in the kidneys.
Consequently , most modern guidelines are based on studies predominantly conducted on men.
Consequently , NF-kappaB dysregulation has been implicated in diverse human pathologies ranging from autoimmune diseases to cancers.
Consequently , older adults require individualization of their pharmacotherapies.
Consequently , osteoporosis is commonly found in thin postmenopausal women.
Consequently , our knowledge of olfactory dysfunction in humans remains primitive.
Consequently , palliative care systems , which will serve a large , aging cohort , will require new skills.
Consequently , periodisation strategies are not essential for optimising neuromuscular adaptations during the initial stages of resistance training in the aging population.
Consequently , pharmacological , gene-based , and cell-based therapeutic attempts have been made to enhance collateral function.
Consequently , phenylketonuria is no longer considered a pediatric disease.
Consequently , preventing or inhibiting Caspase-6 activity in the aged may provide an efficient novel therapeutic approach against Alzheimer disease.
Consequently , pro-inflammatory cytokines are closely implicated in the evolution of intestinal BD.
Consequently , proteasome activity and autophagy are impaired in HGPS cells.
Consequently , resistance-type exercise should be promoted without restriction to support healthy aging in the older population.
Consequently , risk factor detection and assessment are salient.
Consequently , science-based opposition to programmed aging has dramatically declined.
Consequently , self-management training may reduce feelings of loneliness.
Consequently , significant positive correlations were also found between ubiquitin load and histone modifications.
Consequently , sleep efficiency was reduced by @percent@ ( P = @number@ ) and @percent@ ( P = @number@ ) , respectively.
Consequently , such cellular processes become dysfunctional when the ability to keep intrinsically supersaturated proteins soluble is compromised.
Consequently , tendon adapts dynamically during development , aging , and injury.
Consequently , the activated immune cells engage explicit regulatory mechanisms to eliminate senescent cells.
Consequently the aged females will carry more infectious risks.
Consequently , the behavioral performances were significantly improved at @number@ weeks after the injection of hASC.
Consequently , the biological cause ( s ) of frailty are also poorly defined.
Consequently , the furrows and wrinkles were not so deep and dense as in the skin of individuals with a low antioxidant level.
Consequently , the global prevalence of osteoporotic fractures will increase with the aging of the population.
Consequently , the head and neck muscles seemed to receive much fewer sympathetic nerves than limb muscles.
Consequently , their ability to participate in various social activities also became restricted.
Consequently , the need of an effective vaccine is obvious.
Consequently , the number of long-term survivors can be expected to increase in the years to come.
Consequently , the poorer performances of older adults to determine the meaning of pictograms could be explained by the decline of abstraction ability in elderly.
Consequently , the population attributable fractions of major public health problems due to unhealthy lifestyles are large.
Consequently , the prevalence has significantly increased in the observed period and exceeded @number@ cases in @number@
Consequently , the progress toward Universal Health Coverage ( UHC ) in these countries also varies.
Consequently , there are currently no effective therapeutic options that can modify the disease progression and slow or stop the decline of cognitive functioning.
Consequently , there is a high priority for the discovery and development of agents that can successfully treat such conditions.
Consequently , there is an increase in the average age of the interthrocanteric fractures in the elderly population.
Consequently , there is an interest in modifiable factors that may influence PA among older persons.
Consequently , there is a potential for anatomical change of distance from the bifurcation of the aorta to the sacral promontory.
Consequently , there is great interest in improving or stabilizing WM , which drives expanded use of brain training exercises.
Consequently , there is interest in developing androgen supplementation paradigms for old men that replicate the hormone profiles of young adults.
Consequently there is no guidance to help clinicians identify older adults with clinically meaningful low muscle mass or weakness.
Consequently , the strategy that is optimal for one country may be sub-optimal for another country.
Consequently , they are both attended by a considerable socioeconomic burden.
Consequently , they showed neither an abrupt discontinuity in ID-AT relation nor significant changes in the variability of AT / DT ratio across difficulty levels.
Consequently , this study examined burden and QoL in caregivers of youth with OCD enrolled in an intensive outpatient or partial hospitalization program.
Consequently , training measures to improve the older population's cognitive and physical fitness should be promoted to enhance walking speed and safety of older pedestrians.
Consequently , VEGF-induced expression of the FoxO1 responsive genes , VCAM-1 and E-Selectin , was tightly controlled by REGγ in a PKA dependent manner.
Consequently , virulence of old compared to younger C. glabrata cells is enhanced in the Galleria mellonella infection model.
Consequently , visual device and task characteristics should more and more affect tool use.
Consequently , we aimed at addressing whether aging leads to changes in neuromuscular coordination patterns as well as co-activation during quiet stance.
Consequently , we examined the behavioural and neurochemical effects of chronic paroxetine ( PRX ) treatment in adult and adolescent rats.
Consequently we expect to develop a deeper understanding about the function of these two proteins in organismal aging and disease.
Consequently , we found that mental health conditions in caregivers were associated with both the number of caregiver burdens and behavioral problems among care recipients.
Consequently , we hypothesized that the expression and / or activity of ERCC1 and XPF may be associated with age.
Consequently , we propose that targeting NR4A receptors might constitute a new approach to delay aging and the onset of diseases affecting our aging population.
Consequently we set out to determine the longevity of the participants in the Tour de France , compared with that of the general population.
Consequently , we speculate that the capacity of hSuv3 DNA unwinding activity might be sensitive to the local availability of specific inorganic cofactors.
Conservatively , differences of ≥3 points were considered the minimally important difference in HRQL scores.
Conservatively treated locally advanced prostate cancer is associated with poor survival outcome.
Conservative treatment is beneficial in most cases and physiotherapy a major component of the prognosis.
Conservative treatment was chosen significantly more often for nonagenarians ( p = @number@ ) .
Considerable amounts of BAT are present in a substantial proportion of adult humans and relatively high quantities of BAT are associated with lower body weight.
Considerable changes in China's National Tuberculosis Control Program are needed to tackle these emerging challenges faced by health workers at the county level.
Considerable epidemiologic evidence links consuming lower glycemic index ( GI ) diets with good health , particularly upon aging.
Considerable evidence has been gathered supporting the role of aggressive nutrition support and physical therapy in improving outcomes.
Considerable interest in CKD has been generated by the evidence that predialysis CKD is associated with increased risk of cardiovascular disease ( CVD ) .
Considerable progress has been made toward understanding the mechanism of adipogenesis , however , the mechanisms of other actions of PGJ₂ family remain controversial.
Considerable public attention has been focused on the issue of youth violence , particularly that associated with drug use.
Considerable research focus has addressed the application of dietary protein supplementation to support exercise-induced gains in muscle mass in younger individuals.
Considerable resources have been invested in financial incentives , guideline development , public awareness and educational programmes to promote earlier diagnosis and better management.
Considerable work is needed to validate the criteria that use biomarkers and to standardize biomarker analysis for use in community settings.
Considerable work is needed to validate the criteria that use biomarkers and to standardize biomarker analysis for use in community settings.
Consideration is given to the following questions : Is gerotranscendence really age-related , and is it really universal rather than culturally or personality dependent ?
Consideration must also be given to caregivers and the education of health professionals as well as to the mode of intervention itself.
Consideration of , and alternatives for , these patient cohorts should be considered.
Consideration of base rate data regarding the percentage of healthy individuals scoring in the abnormal range should help avoid classifying normal variability as neuropsychological impairment.
Consideration of mitochondrial energy metabolism in the skin creates a new perspective for both dermatologists and experts in metabolic disease.
Consideration of these gender differences is necessary to improve the effectiveness of active living promotion programs among older adults.
Consideration of these questions produce many caveats that should guide future investigations to move the field forward.
Consideration of this concept in forthcoming drug design , screening , and testing programs may prevent such failures in the future.
Considerations are made on how successes were brought about , what can be learned as well as what issues should be addressed in the future.
Consideration should be given to addressing the patient-specific needs regarding the systemic changes seen in the aging patient.
Consideration should be given to current infection control strategy , which advocates household contact screening and decolonization on the assumption that PVL-associated disease is rare.
Consideration to case finding for depressed mood among older people with visual impairment might be justified.
Consideration to how these themes may be addressed by the Association of Gerontology in Higher Education is offered.
Consideration will be given to how aging and immunosenescence may contribute to CHIKV's atypical and more-severe clinical features in older adults.
Considered key is the urgent need to effectively stem chronic noncommunicable diseases ( NCDs ) .
Considering all of these age-related changes to the lungs , pulmonary disease has significant consequences for the aging population.
Considering all patients , the left ventricle ejection fraction ( LVEF ) was not statistically different in the two cohorts.
Considering a patient's goals for surgery and comprehensive presurgical counseling are important determinants of patient satisfaction.
Considering appropriate criteria , only nine studies were analyzed in the meta-analysis , including @number@ aggressive PCa and @number@ controls.
Considering dizziness to be a geriatric syndrome with multiple contributory factors may provide additional leads for treatment.
Considering further the accompanying eye , study eyes with ARM had significantly higher MPOD when the contralateral eye had AMD.
Considering individual and environmental factors , within the retirement village and neighbourhood settings , and associations with PA , warrants attention.
Considering it to be physiological about half of the subjects ( @percent@ ) did not seek treatment.
Considering \ "Men's health \ " , LOH is an important issue for the quality of life of elderly males.
Considering other aspects , tumor biology may explain the different outcomes.
Considering personalized and collective needs allowed identifying exclusive examples of each.
Considering sex as a biological variable in dementia research promises to advance our understanding of the pathophysiology and treatment of these conditions.
Considering that GnT-III-deficient mice remain healthy , GnT-III may be a novel and promising drug target for AD therapeutics.
Considering that OA requires long-term treatment , therapies with minimal side effects and which can be repeated as needed are warranted.
Considering the age , @number@ groups were distinguished : group I - women at the age 71- @number@ and group II - women aged 81-87.
Considering the aging perioperative nursing workforce , residency programs could address critical needs for succession planning.
Considering the anti-oligomerization property of all-trans retinoic acid ( ATRA ) , the involvement of monomeric Aβ1-42 in ATRA-induced neuronal differentiation has been investigated.
Considering the diagnostic challenges of AAP in the elderly , liberal CT use can be advocated in this patient group.
Considering the difficulties of reliably ageing adult human skeletal remains , this is a major issue for studies of activity using enthesopathies.
Considering the empirical proposition that several physical and mental trajectories may exist , Latent Class Growth Modeling was used.
Considering the high prevalence rate of depression in this community and its disabling effects on QOL , interventions to prevent and treat depression are essential.
Considering the increasing prevalence of both conditions along with the aging of the population , further investigations of this important issue are highly needed.
Considering the less-frequent fall rate in the follow-up assessment , these improvements could contribute to preventing falls in community-dwelling older adults.
Considering the level of repeatability and the correlations to tonometry , the overall best DPA parameters were EEI , AI and b / a.
Considering the limitations of the study , further and decades long epidemiological evaluations are suggested in a larger study population.
Considering the pool of normoresponders , MCL was not correlated with pregnancy rate while a positive association was found with patients ' age.
Considering the recovery of individual items is necessary to understand and account for individuals differences in the order of recovery.
Considering the results , a larger study concerning nutritional status , functionality and falls in the hospitalized population is warranted.
Considering these positive effects , we argue that a decline in physical activity has a detrimental effect on cognition and behavior in patients with dementia.
Considering the traditional culture of Confucius on modesty , the present study hypothesizes that there should be no significant SEB among Chinese elders.
Considering the unexpectedly rapid aging of the Japanese population after this figure was reported , it would be worthwhile to examine more recent data.
Considering VACS index at HI and @number@ months improved outcome prediction and allowed earlier risk assessment.
Considering WLR and WCSA , a distinction between eutrophic and hypertrophic retinal remodeling processes was possible.
Consistent evidence demonstrated that executive functions and dual-task performance were highly associated with falls or falls risk.
Consistent for all subjects , the perfusion decreases significantly from the lesser trochanter to the greater trochanter.
Consistent indirect effects were observed from health status and sense of control to all @number@ of these outcomes via perceived work ability.
Consistently , ALA increased serum FGF21 levels in both fasted and fed mice.
Consistently , a phospho-mimetic S321D RIPK1 mutation limits TNF-induced death.
Consistently , both CUTA and copper levels were decreased in the hippocampus of APP / PS1 AD mouse brain.
Consistently , both enzymatic families have been linked to mechanisms of aging and carcinogenesis in mice and humans.
Consistently , confocal microscopy studies of mitochondrial fluorescent probes confirmed the mitochondrial derangement.
Consistently , global metabolomic and phenotypic analyses disclose an unbalanced redox status , decreased glutamine anaplerosis and mitochondrial function.
Consistently , higher circulating lycopene levels significantly reduced the risk of PCa.
Consistently , HO has been shown to restore tissue morphology by potentiating potentiate proteins of repair / regeneration and promoting neovascularization.
Consistently , Hsp70 treatment also protects spatial memory in OBX and 5XFAD mice.
Consistently increased risks were observed for paternal smoking and maternal overweight , obesity and diabetes , but not for maternal smoking and alcohol consumption.
Consistently , inhibiting gephyrin palmitoylation either pharmacologically or by expression of palmitoylation-deficient gephyrin reduced the gephyrin cluster size.
Consistently , knockdown of Tcad in cultured murine vascular ECs significantly diminished Adipo binding.
Consistently low Aβ1-40 and Aβ1-42 levels on both measurements were associated with accelerated progression of WMH.
Consistently , mutation or deregulation of different KATs or HDACs contributes to neurological dysfunction and neurodegeneration.
Consistently , pharmacological inhibition of PI3K activity reduced osteoblast differentiation and abolished Wnt regulatory gene expression induced by α5β1 integrin priming.
Consistently , pharmacological modulation of EPAC activity instructed cell differentiation , number of neurites , and neurite length in N1E-115 cells.
Consistently , selenium depleted ROS levels downstream of NOX4 induction.
Consistently , silencing of miR-33b-3p in the cisplatin-resistant A549 / DDP cells evidently sensitized the cells to cisplatin.
Consistently , SIRT1 knockdown led to improper condensation and overall aberrant mitosis.
Consistently , the combination of NADPH and apocynin produced greater beneficial effects in against ischemic brain damage.
Consistently , the recruitment of mTORC1 to the lysosome was suppressed by the dynamin inhibition.
Consistently , this inhibition increases the expression of mutant TDP-43 in glial cells in mouse brains.
Consistent moderate activities facilitate cycles of anabolism and catabolism.
Consistent , natural , and long-lasting aesthetic results are achieved.
Consistent over-estimation of individuals younger than @number@ and under-estimation of individuals over @number@ years old occurred.
Consistent results were found for accelerated disability and mortality.
Consistent with a neuroprotective effect , rs7594645-G carriers exhibited increased hippocampal volume and gray matter density and decreased cerebrospinal fluid levels of apoptotic mediators.
Consistent with earlier research , the findings showed that younger adults can bypass when the second task has ideomotor-compatible stimuli and responses.
Consistent with ER calcium dysregulation , we observed striatal upregulation of S1R in aged YAC128 transgenic HD mice and HD patients.
Consistent with existing sacropenia literature , the pharyngeal muscles appear to atrophy with age and consequently , the size of the pharyngeal lumen increases.
Consistent with findings using laboratory stimuli , older adults were more susceptible to AM conjunction errors than younger adults.
Consistent with FOXO-dependent protein quality control , TDP-43 regulates the levels of misfolded proteins.
Consistent with increased iron utilization , soluble transferrin receptor ( sTR ) levels and ratio of sTR / log ferritin increased significantly in testosterone-treated men.
Consistent with its abundant expression in mouse and human testes , male mice deficient for Ing2 showed abnormal spermatogenesis and were infertile.
Consistent with its effect on Aβ transport , Aβ mixture treatment for 24h resulted in LRP1 down-regulation and RAGE up-regulation in hCMEC / D3 cells.
Consistent with other studies these data support the association between depression and diabetes ( OR = @number@ 95%CI : @number@.1-2.7 ) .
Consistent with our data in humans , these miRNAs are also present at lower levels in the serum of elderly rhesus monkeys.
Consistent with our hypothesis , the highest number of @number@'- and @number@'-breakpoints per base is found in the highly structured tRNA genes.
Consistent with our hypothesis , there were age-related differences in how category representations related to the subjective sense of vividness.
Consistent with our other studies , we found evidence of elevated T-SCE in telomerase-negative but not telomerase-positive backgrounds.
Consistent with our prediction , significant cognitive fatigue effect was observed in executive attention but not in alerting or orienting.
Consistent with our previous results , coherence thresholds in the youngest children assessed were adult-like at the two conditions with the largest Δx.
Consistent with our second hypothesis , forehead cooling reduced CBV under propranolol despite a significant rise in RPP.
Consistent with Park et al.
Consistent with previous findings of motor slowing with aging , the fastest inter-tap interval increased with age.
Consistent with previous findings , the amplitude difference tended to be generally reduced in older subjects.
Consistent with previous findings , young adults showed a retrocue benefit , whereas healthy older adults did not.
Consistent with previous literature , women scored higher on depressive symptoms than men.
Consistent with previous results , speed ability and fluid cognitive ability were strongly correlated with trail making performance.
Consistent with previous results , we found a relatively low level of driving self-restriction and infrequent episodes of aggressive violations.
Consistent with previous studies , most memories came from the period in which the participants were between @number@ and @number@ years old.
Consistent with previous studies , we show that resistance to BRAFi is mediated by ERK pathway reactivation.
Consistent with PS , MPS was greater with 2RDA vs. 1RDA , regardless of distribution patterns.
Consistent with reduction of CUGBP1 in animal models , CUGBP1 is reduced in patients with pediatric liver cancer.
Consistent with the diagnosis of Alzheimer's pathology , positron emission tomography ( PET ) with Pittsburgh compound B suggested the presence of beta-amyloid.
Consistent with the HF findings , higher adiponectin tended to be associated with left ventricular systolic dysfunction and left atrial enlargement.
Consistent with the intracellular expression levels , CA9 was abundantly detected in exosomes isolated by ultracentrifugation from OSRC-2 cells.
Consistent with the mPTP sensitization , older muscles showed a 3-fold greater fraction of endonuclease G ( a mitochondrial proapoptotic factor ) -positive myonuclei.
Consistent with the previous studies , outside problems were perceived as being more severe than inside problems.
Consistent with these beneficial effects on the cellular level , E2 improves hippocampus-dependent memory.
Consistent with these data , irradiating adult mice did not increase mammary repopulating activity or ER-negative tumors.
Consistent with these findings , epidemiological analysis indicated that certain NSAIDs may prevent or delay the progression of PD.
Consistent with these findings , PARP-1 suppression impairs mitochondrial ATP production.
Consistent with these in vivo observations , we find that FOXO3 controls autophagic flux in neuronal cells.
Consistent with these results , treatment with exogenous human POT1 protein maintains human HSC activity in culture.
Consistent with the weathering hypothesis , many studies have captured racial / ethnic disparities in average functional health trajectories.
Consistent with this focus , the key contact person was most often an allied health team member.
Consistent with this hypothesis , response accuracy was lower for high school students compared to their older counterparts.
Consistent with this hypothesis , the inhibition of autophagy promotes oxidative stress , genomic instability , and tumorigenesis.
Consistent with this idea , males show greater loss of mitochondrial gene expression with age.
Consistent with this , inactive mutants of GAPDH failed to bind TRAF2 , enhance HIF-1 activity or promote lymphomagenesis.
Consistent with this mechanism in vivo , we found that a recombinant deubiquitinase module is active in the absence of Ataxin-7 in vitro.
Consistent with this observation , significant hypoacetylation of H3K9K14 was detected in young subjects with schizophrenia when compared with age-matched controls.
Consistent with this , oral glucose insulin sensitivity and plasma lipid concentrations did not change or differ between groups.
Consistent with this pattern of intracellular protein redistribution , impaired nucleocytoplasmic trafficking has emerged as a mechanism contributing to ALS pathology.
Consistent with this , premature loss of centromeric cohesion is a major source of aneuploidy in oocytes from older women.
Consistent with this we found altered lysine acetylation levels and deacetylase activity in the brains of SCA7 transgenic mice.
Consonance and dissonance form the basis of harmony , a central component of Western music.
CONSORT reporting quality of physical activity interventions was higher than that of cognitive interventions.
Constant comparative analysis methods will be used for data analysis.
Constant comparative analysis , the core foundation of grounded theory was used.
Constant comparison methods identified themes by ethnicity.
Constant environmental light of moderate intensity ( ~100 lx ) slows down the circadian clock in rhesus monkeys.
Constitutive autophagy has a housekeeping role and is essential for survival , development and metabolic regulation.
Constitutively active MEK1 , but not constitutively active ERK2 , induced upregulation of TβRII.
Constitutive model accurately portrayed orthotropic stiffening with age of both normal and diabetic arteries.
Constructing a model of how FoxO responds to diverse environmental factors provides a framework for how stem cell factors might contribute to aging.
Construction of new models for delivery of health and social care.
Constructs of control have theoretically been equated to successful aging in the psychology literature.
Constructs of personality , including self-concept , self-acceptance , destiny control , interiority , rigidity , and flexibility , are described.
Construct validity of a functional status measure composed of these domains was assessed as part of this goal.
Construct validity of S-FNAME showed @number@ components : face-name and face-occupation.
Construct validity of the PASE total score was low in both men ( r = @number@ ) and women ( r = @number@ ) .
Construct validity of the scale was also very good based on factor analysis.
Construct validity was determined using confirmatory factor analysis.
Construct validity was moderate / high for QoL-ADc ( QUALID = -0.43 ; EQ-5D = @number@ ) , but lower for QoL-ADp.
Consultant role models are an important career influence.
Consultants were more likely to detain patients with a wider variety of disorders , with more admissions to and detentions in psychiatric hospital care.
Consultation included ; transvaginal ultrasound ( AFC , ovarian volume , pathology ) , a full reproductive history and AMH measurement.
Consultation was requested most frequently for assessing psychotropic medication , decision-making capacity or altered mental status , or for assistance with behavioral problems.
Consumed resources increased with the severity of chronic pain.
Consumer behavior differs among individuals ; one such common individual difference is financial extravagance.
Consumer liking scores for tomato soup showed that micronutrient addition affected liking when @percent@ of a daily dose was added into the soup.
Consumer panelists ( = @number@ ) evaluated samples for tenderness , juiciness , flavor liking , and overall liking.
Consumer ratings seem to depend on regional tastes and preferences.
Consumer's concern on aging and age-related diseases challenges scientists to underline the potential role of food on the extension and guarantee of lifespan and healthspan.
Consumer scores showed an increasing trend in beef liking with aging time.
Consumers from Pamplona assigned lower ( P < @number@ ) hedonic scores for beef liking than consumers from Barcelona and Zaragoza.
Consuming a high-fat diet may result in behavioral deficits similar to those observed in aging animals.
Consuming animal products to almost all main meals was observed in case of many individuals in all analyzed groups.
Consuming foods exclusively from the children's menu may help limit overconsumption in QSRs.
Consuming protein following exercise has been shown to stimulate protein synthesis acutely in skeletal muscle and has been recommended to prevent sarcopenia.
Consumption of AChEIs and memantine was assessed using the Pharmacy Unit database from the Public Catalan Healthcare Service.
Consumption of BR increased plasma nitrite in both young and older adults ( P < @number@ ) .
Consumption of ICU resources by octogenarians was lower in terms of length of stay , mechanical ventilation , and renal replacement therapy.
Consumption of larger amounts of DHA appears to reduce the risk of depression , bipolar disorder , schizophrenia and mood disorders.
Consumption of @percent@ fruit juice was marginally associated with longer telomeres ( b = @number@ @percent@ CI = @number@ @number@ P = @number@ ) .
Consumption of protein before sleep confers the anabolic responses required for the maintenance of lean mass and muscle recovery.
Consumption of water nearly saturated with H2 also prevents chronic neurodegenerative diseases including Parkinson's disease in animal and clinical studies.
Consumption of whey protein has a robust ability to stimulate muscle protein synthesis.
Consumption patterns of milk in different states may be related to the regional differences in height.
Contact dermatitis from irritant and allergic sources is the reason for @percent@ to @percent@ of all dermatologic visits with considerable morbidity and economic impact.
Contact dermatitis is a significant health problem affecting the elderly.
Contact dermatitis is the most frequent side effect of external preparations.
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CONTACT HOURS This activity is co-provided by Villanova University College of Nursing and SLACK Incorporated.
Contact-inhibition of biofilm formation was retained by the aged experimental material.
Contact lens corrections show less progress and are still preferred only by a minority of older patients , most of whom are early presbyopes.
Contact skin cooling ( 5-20degC ) was provided via a sapphire window at the distal end of handpiece.
Contemporary data on a large cohort of patients is lacking.
Contemporary demographic trends cause aging of the society.
Contemporary research has increasingly acknowledged the importance of attachment on stress-related processes in ageing.
Contemporary research suggests that the benefits of physical exercise , for both middle- and older-aged individuals , are undisputable.
Contemporary state-of-the-art healthcare facilities are incorporating technology into their building design to improve communication and patient care.
Content analysis included open coding , axial coding and integration of the main findings using constant comparisons.
Content analysis revealed unmet needs for basic supports , including housing , economic supports , and help with entitlements.
Content analysis was carried out and a pool of questionnaire items compiled.
Content analysis was used to analyse the data that related to homebirth.
Content analysis was used to analyze the data.
Content analysis was utilized to analyze the qualitative data.
Content analysis with coding was utilised for synthesis of results.
Content-based refinements and morphological operations are then applied to obtain the final segmentation.
Content development used nominal group process , expert narratives , and literature review.
Content , face and construct ( exploratory factor analysis ) validities of the AAQ were assessed.
Content published in Science Signaling explores the molecular mechanisms that regulate neuronal development and function and that are altered in neurological dysfunction and neurodegenerative disease.
CONTENTS : In the developed world , most of the present population will spend roughly half their lives as presbyopes.
Content validity , construct validity , internal consistency , and stability reliability were assessed.
Content validity of the ICF core set was found to be fair ; responsiveness appears to be very poor.
Content validity was also tested on five physical therapists.
Content validity was assessed by expert evaluation.
Content validity was confirmed and ' test ' users reported few difficulties in its use and high satisfaction.
Content validity was examined by identified experts , followed by exploratory factor analysis , item-to-total correlation , Cronbach's α coefficients and test-retest reliability.
Content validity was good based on expert evaluations.
Context : Accumulation of brain iron is linked to aging and protein-misfolding neurodegenerative diseases.
CONTEXT : Acute ST-segment elevation myocardial infarction ( STEMI ) is a leading cause of morbidity and mortality.
Context : A diminished muscle anabolic response to protein nutrition may underpin age-associated muscle loss.
CONTEXT : Administration of chemotherapy to premenopausal women shortens their reproductive lifespan by depleting nonrenewable oocytes.
CONTEXT : Advance care planning ( ACP ) has focused on documenting life-sustaining treatment preferences in advance directives ( ADs ) .
CONTEXT : Advanced glycation end-products ( AGEs ) are thought to be involved in the pathogenesis of Alzheimer's disease.
CONTEXT : Age-related bone loss is associated with progressive changes in bone remodeling characterized by decreased bone formation relative to bone resorption.
CONTEXT AND OBJECTIVE : : Aging causes changes in men and women.
CONTEXT AND OBJECTIVE : An inverse correlation between plasma testosterone levels and carotid intima-media thickness ( IMT ) has been reported in men.
Context and Objective : Diabetes is associated with a greater risk for incident cardiovascular disease and cognitive dysfunction.
CONTEXT AND OBJECTIVES : The new social panorama resulting from aging of the Brazilian population is leading to significant transformations within healthcare.
CONTEXT : Androgen modulation of erectile function ( EF ) is widely accepted.
Context and time differentials in shape imply that the relationship between income and mortality is not fixed.
CONTEXT : An impaired muscle protein synthetic response to feeding likely contributes to muscle loss with aging.
CONTEXT : Anti-Müllerian hormone ( AMH ) , which is secreted by immature Sertoli cells , triggers the involution of the fetal Müllerian ducts.
CONTEXT : Antimuscarinics are the drugs of choice for the treatment of detrusor overactivity ( DO ) and overactive bladder ( OAB ) syndrome.
CONTEXT : A number of neuroactive progesterone metabolites produce sedative-like effects.
Context : Areal bone mineral density ( BMD ) measurements are confounded by skeletal size.
CONTEXT : A relation between low thyroid activity and prolonged life span in humans has been observed.
CONTEXT : A significant challenge facing health care is the ageing of the population , which calls for a major response in medical education.
CONTEXT : As of @number@ @number@ million people worldwide were older than @number@ y , accounting for @percent@ of the population.
CONTEXT : Baby boomers are commonly believed to be healthier than the previous generation.
Context : Both type @number@ diabetes ( T2D ) and osteoporosis are affected by aging and quite often coexist.
CONTEXT : Cancer patients experience a broad range of physical and psychological symptoms as a result of their disease and its treatment.
CONTEXT : Characterizing where people die is needed to inform palliative care programs in Mexico.
Context : Chronic psychological stress has been associated with shorter telomeres , but the underlying mechanisms are poorly understood.
CONTEXT : Circulating PTH concentrations increase with age.
CONTEXT : Cleistocalyx nervosum ( DC. )
CONTEXT : Cognitive impairment in late-life depression is a core feature of the illness.
CONTEXT : DTD is a Chinese herb prescription used for centuries to treat atherosclerosis or dizziness.
CONTEXT : Equol is a polyphenolic / isoflavonoid molecule that can be expressed as isomers.
CONTEXT : Estimating life expectancy is challenging in advanced dementia , potentially limiting the use of hospice care in these patients.
CONTEXT : Families of persons with dementia continue to report unmet needs during end of life ( EOL ) .
CONTEXT : Fibroblast growth factor-21 ( FGF21 ) is an important metabolic regulator suggested to improve glucose metabolism and prevent dyslipidemia.
CONTEXT : Ganoderma lucidum ( Leyss : Fr ) Karst.
CONTEXT : Genetic factors contribute to the development of obesity.
CONTEXT : Growing evidence demonstrates that hyperparathyroidism is associated with an increased risk of cardiovascular morbidity and mortality.
CONTEXT : Hemoglobin A1c ( A1c ) was recently added to the diagnostic criteria for diabetes and prediabetes.
CONTEXT : Higher metabolic rates increase free radical formation , which may accelerate aging and lead to early mortality.
CONTEXT : High vitamin D and physical activity ( PA ) levels are independently associated with improved body composition and muscle function in older adults.
CONTEXT : Human papillomavirus ( HPV ) and Chlamydia trachomatis are the most frequent sexually transmitted infections , usually asymptomatic.
Context : Hypertension in young women is uncommon compared with young men and older women.
CONTEXT : Immunochemical fecal occult blood tests ( iFOBTs ) are potentially promising tools for colorectal cancer screening.
CONTEXT : Immunohistochemical ( IHC ) stains have known utility in prostate biopsies and are widely used to augment routine staining in difficult cases.
Context : Increased evening cortisol levels have been implicated in bone mineral density ( BMD ) loss.
CONTEXT : Insulin resistance and type @number@ Diabetes have been associated to a low grade of inflammation and their prevalence increase with ageing.
CONTEXT : It has been demonstrated that the ageing process affects esophageal motility.
CONTEXT : It is unclear whether declining sexual function in older men is a cause or consequence of reduced androgen status.
CONTEXT : Kidney , prostate , and bladder cancers increase with age and are influenced partly by modifiable risk factors.
CONTEXT : Liver enzyme serum levels within and just above the normal range are strong predictors of incident morbidity and mortality in the general population.
Context : Low levels of nonandrogenic anabolic hormones have been linked with frailty , but evidence is conflicting and prospective data are largely lacking.
CONTEXT : Major depressive disorder ( MDD ) in elderly individuals is prevalent and debilitating.
CONTEXT : Many medical schools have initiated care internships to familiarize their students with older persons and to instil a professional attitude.
CONTEXT : Measurement of IGF-binding protein-3 ( IGFBP-3 ) can aid the diagnosis of GH-related diseases.
CONTEXT : Mexico.
CONTEXT : Mutations of the fragile X mental retardation @number@ ( FMR1 ) gene are associated with distinct ovarian aging patterns.
CONTEXT : Older oncology patients have unique needs associated with the many physical , psychological , and social changes associated with the aging process.
CONTEXT : Optimal treatment to postpone functional decline in patients with dementia is not established.
CONTEXT : Osteoarthritic knee pain is very common , as are leg length discrepancies ( LLDs ) .
CONTEXT : Osteoporosis is a systemic disease with a strong genetic component.
CONTEXT : Over the history of palliative care provision in Ireland , services have predominantly provided care to those with cancer.
CONTEXT : Patient death is common in long-term care ( LTC ) .
CONTEXT : Pheochromocytomas and paragangliomas ( PPGLs ) are diagnosed earlier in patients with hereditary than sporadic disease.
CONTEXT : Preclinical studies suggested the existence of a signaling pathway connecting bone and glucose metabolisms.
CONTEXT : Pseudohypoparathyroidism ( PHP ) is defined as resistance toward parathyroid hormones.
CONTEXT : Reference intervals for bone turnover markers ( BTMs ) and relationships between BTM and fracture risk in older men are not well characterized.
CONTEXT : Sarcopenia is thought to be associated with mitochondrial ( Mito ) loss.
CONTEXT : Several alterations in thyroid function test ( TFT ) results have been associated with mortality in elderly patients.
CONTEXT : Several fracture prediction models that combine fractures at different sites into a composite outcome are in current use.
CONTEXT : Several studies have evidenced the association between subclinical hyperthyroidism and cognitive impairment in the elderly.
CONTEXT : Skeletal muscle from sedentary older adults exhibits reduced mitochondrial abundance and oxidative capacity.
CONTEXT : Skeletal muscle protein synthesis is highly responsive to food intake.
CONTEXT : Studies examining whether vitamin D supplementation increases muscle mass or muscle-specific vitamin D receptor ( VDR ) concentration are lacking.
CONTEXT : Studies of the influence of sex , age , and body weight on TSH secretion are not unanimous.
Contexts were semantically congruent , neutral , or incongruent.
CONTEXT : Telomere biology plays a fundamental role in genomic integrity , cellular regeneration , physiology , aging , disease risk , and mortality.
CONTEXT : Telomeres are biomarkers of biological aging.
CONTEXT : Telomeres are specialized chromatin structures located at the ends of eukaryotic chromosomes , and telomere length plays a clear role in various diseases.
Context : Testosterone prescribing rates have increased substantially in the past decade.
CONTEXT : Testosterone ( T ) levels decline with age and lower T has been associated with increased mortality in aging men.
CONTEXT : The appropriateness of current reference ranges for thyroid function testing in older adults has been questioned.
CONTEXT : The association between aging and falls risk , and the morbidity and mortality resulting from falls in older persons , is well documented.
CONTEXT : The association between early menopause and vascular disease as a possible causative factor has recently received attention.
CONTEXT : The association between subclinical hyperthyroidism and the risk of dementia has been validated in several studies.
CONTEXT : The best evidence suggests that feeding tubes are ineffective in persons with advanced dementia.
CONTEXT : The currently applied reference ranges for thyroid function are under debate.
CONTEXT : The hormonal factors involved in the regulation of peak bone mass ( PBM ) in men have not been fully investigated.
CONTEXT : The impact of older age and duration of diabetes mellitus on macrovascular complications is unclear.
CONTEXT : The international cohort of hemodialysis patients is aging and increasing in number.
CONTEXT : The longitudinal relationship between declining levels of reproductive hormones and cognitive function remains unclear in older men.
CONTEXT : The optimal treatment strategy for muscle-invasive bladder cancer remains controversial.
CONTEXT : The proportion of patients disenrolling from hospice before death has increased over the decade with significant variations across hospice types and regions.
CONTEXT : There is a controversy regarding the definition of vitamin D insufficiency as it relates to bone health.
CONTEXT : There is controversy around the association between depressive symptoms and age in adult cancer patients.
CONTEXT : The relationship between TSH and T₄ is thought to be inverse log-linear , but recent studies have challenged this.
CONTEXT : The social environment may influence cognitive function in aging.
CONTEXT : The widespread use of T therapy , particularly in aging males , necessitates knowledge of the relationship between T and the cardiovascular system.
CONTEXT : Timing of menopause is largely influenced by genetic factors.
CONTEXT : To establish the clinical utility of serum sclerostin levels , it is important to know whether there is seasonal variation in the measurements.
CONTEXT : Type @number@ diabetes mellitus ( DM ) is associated with higher bone mineral density ( BMD ) and paradoxically with increased fracture risk.
Contextual evaluation permitted a much deeper understanding of the influences on changing practice in this hierarchical bureaucracy.
Contextual facilitation was modulated by older listeners ' verbal working memory ( measured with a backward digit span task ) and age across listening conditions.
Contextual influences may promote and impede social participation.
Contextual variables explained @percent@ of the variance in walking speed , and lifestyle / anthropometric variables explained an additional @percent@.
CONTEXT : Vismia cauliflora A.C.Sm.
CONTEXT : Vitamin D deficiency and frailty are common with aging , but the association between these conditions is uncertain.
CONTEXT : Vitamin D is essential for bone health.
CONTEXT : Vitamin D is known to influence muscle health.
CONTEXT : Vitamin D receptor ( VDR ) polymorphisms are associated with a variety of diseases , which may translate into an effect on mortality.
CONTEXT : Vitamin D ( Vit-D ) deficiency is associated with type @number@ diabetes mellitus ( DM ) and endothelial dysfunction.
CONTEXT : With better antiretroviral treatments ( ARTs ) , persons living with HIV ( PLWH ) are living longer , healthier lives.
Context : With prolonged life expectancy , we often encounter patients with elderly-onset type @number@ diabetes mellitus ( eT2DM ) .
CONTEXT : α-Klotho has emerged as a powerful regulator of the aging process.
Continuation of personal counseling and supervision after the conclusion of the program is also essential.
Continuation of scientific activity became guarantee of their health and longevity.
Continuation of the program will require evaluation demonstrating equal or better resident-level outcomes and the development of sustainable business models.
Continued basic research and clinical investigations will be required to develop strategies to overcome age-related voice disorders.
Continued efforts in public education on the proper application of sunscreens and the practice of photoprotection in general are needed.
Continued elucidation of the links between metabolic disorders and neural dysfunction promises to foster the development of effective therapeutic strategies.
Continued generation of new B cells within the bone marrow is required throughout life.
Continued optimization and development of technologies have enabled researchers to probe the mechanisms of telomere maintenance in ever expanding areas.
Continued research is necessary to better understand both AD and CICI.
Continued research is warranted to help guide prospective directions for caregiver interventions focusing on increasing caregiver resilience and the corresponding impact on caregiver health.
Continued research with nonhuman primates is essential for the development of therapies that are optimal for the maintenance of women's cognitive health throughout the lifespan.
Continued study is warranted to verify this association and determine how to incorporate consideration of chronic disease and multi-morbidity into fall risk assessments.
Continued study of the KEEPS population will provide evidence of the effects of HT on the skin aging process in early menopausal women.
Continuing education in practice is important and nurses should lead innovations in education for HCAs.
Continuing efforts for enrolling elderly breast cancer patients in contemporary clinical trials , and thus improving age-appropriate care , are emphasized.
Continuing to clarify the underlying factors impacting SPSA between groups may inform tailored interventions to promote successful aging in Y-O and O-O adults.
Continuing waves of HAALSI data will be a key resource for understanding differences in the complex processes of disability across LMIC contexts.
Continuity in home care was defined as a participant living at home @number@ year after the beginning of the study.
Continuity of care was defined as the hospital physician also billing for an outpatient visit within @number@ days of that hospital admission.
Continuity of identity was linked both to being ' just like always ' and ' just like everyone else'.
Continuity of physician care from the outpatient setting to the hospital was associated with lower hospice referral ( AOR @number@ @percent@ CI @number@.73-0.85 ) .
Continuity seems adaptive , yet prioritising continuity may not match the expectations , desires and realities of older people.
Continuity Theory proposes ageing well is achieved through continuity of activity and stability of relationships and identity over the life course.
Continuity was experienced as the exception and discontinuity as the rule.
Continuity was important for older people in this study , who described a range of practices that supported internal and external continuity.
Continuous bladder irrigation ( CBI ) is a supplementary option for preventing the adverse events following transurethral resection of the prostate ( TURP ) .
Continuous chemical investigation of the gorgonian coral Micronutrient deficiencies and inadequacies constitute a global health issue , particularly among countries in the Middle East.
Continuous efforts might be needed to sustain improvements in patient outcomes.
Continuous electroencephalogram ( EEG ) measures were collected during baseline and fact and source retrieval in order to examine memory-related changes in EEG power.
Continuous exercise adherence seems to be needed to sustain the training-induced effects on BDNF in older persons.
Continuous HR time series were obtained during supine rest and submaximal steady state exercise.
Continuous investigation into HSC biology should facilitate the utilization of HSCs as a therapeutic modality and helps to prevent HSC malfunction.
Continuous log-linear associations were found between usual SBP and risk of major vascular events throughout the SBP range examined ( 145-170 mm Hg ) .
Continuous measures of carotenoids improved survival ( HR = @number@ @percent@ CI = @number@.51-0.89 , P = @number@ ) .
Continuous monitoring of diastolic heart sounds and systolic time intervals is possible using acoustic cardiography.
Continuous monitoring of the diabetes epidemic among the Canadian First Nations population is necessary to inform public health practice.
Continuous outcomes were analyzed with mixed-effects modeling and dichotomous outcomes with logistic regression.
Continuous positive airway pressure ( CPAP ) represents the gold standard therapy , but its benefit is still to be determined in very elderly.
Continuous progressive and strenuous exercises until exhaustion , but not submaximal workload , resulted in a significant enhanced accumulation of carbonylated proteins in the plasma.
Continuous proliferation of atypical melanocytes was found in @number@ ( @percent@ ) LM or LMM and in @number@ ( @percent@ ) benign lesions.
Continuous studies have shown that insula may be an important target of AD , but neuropathological alterations have not been described extensively.
Continuous wavelet transforms were calculated for each muscle EMG response.
Contractile , cytostructural and mitochondrial proteins were most abundant consistent with electron micrographs of the Drosophila cardiac tube.
Contraction intensity did not influence the amount of D1 inhibition or heteronymous Ia facilitation for either group of subjects.
Contradicting the prevailing hypotheses , we found no significant evidence that long-lived mammals possess fewer mutagenic DRs than short-lived mammals.
Contradictory results for the effect of physical activity on BMLs may be explained by a dose-response relationship , knee alignment , and structural lesions.
Contradictory results for the effect of physical activity on BMLs were found.
Contraindications to testosterone-replacement therapy include prostate and breast cancers , uncontrolled congestive heart failure , severe lower-urinary-tract symptoms , and erythrocytosis.
Contraindications were present in @number@ of the patients ( @percent@ ) and were more frequent in under-treated patients.
Contrariwise , NER deficiency leads to a striking transgenerational decline in replicative capacity and viability of proliferating cells.
Contrary , studies investigating diets high in saturated fats provide opposite results , which may eventually lead to irreversible damage.
Contrary to acute studies , consuming protein after exercise did not increase skeletal muscle protein synthesis rates.
Contrary to adiponectin , high serum aP2 levels were correlated with the late development of MetS.
Contrary to a growing clinical literature , depression may not increase cardiometabolic risk among older adults on average.
Contrary to BAFF , APRIL binds heparan sulfate proteoglycans ( HSPGs ) , which regulates cross-linking of APRIL and efficient signaling.
Contrary to common belief , we have found that expression of SRD5A2 is variable and absent in one third of benign adult prostates.
Contrary to current living arrangement patterns found among older immigrants , very few respondents preferred to move in with their children.
Contrary to expectation , FTD was not more impaired in everyday executive abilities.
Contrary to expectations , income level was not associated with any APQ-S dimension.
Contrary to expectations , rehospitalization rates do not rise substantially with advancing age , and rehospitalization is often for noncardiac diagnoses.
Contrary to much of the current literature , grandchild care was found to be potentially beneficial for grandmothers.
Contrary to other craniofacial structures , neither age-related changes nor sexual dimorphism were found for ' p ' and ' t'.
Contrary to other reports worldwide , there were no cases of death in nursing homes , possibly due to underreport or misidentification.
Contrary to our hypothesis , there was no difference between the training groups in negative interpretation bias.
Contrary to our prediction , however , older adults verbally and nonverbally expressed fewer positive emotions than their younger counterparts.
Contrary to popular belief , sex hormones act throughout the entire brain of both males and females via both genomic and nongenomic receptors.
Contrary to predictions , EC did not modulate the N1 response.
Contrary to predictions , older adults were less able to take advantage of this memory benefit than younger participants.
Contrary to previous reports , disparity thresholds increased between the ages of @number@ and @number@ years.
Contrary to previous studies , we conclude that healthy aging does not affect the calculation efficiency of the detection process at low spatial frequencies.
Contrary to previous transgenic models , we have recapitulated ALS-like phenotypes without overexpression of the mutant protein.
Contrary to primary cells , impaired eIF2αP in immortalized mouse fibroblasts or human tumor cells provides tolerance to elevated intracellular ROS levels.
Contrary to recent reports , CSF p-tau was not significantly reduced in ALS patients compared with control subjects ( p = @number@ ) .
Contrary to some prior research , education level was not associated with use of MBT.
Contrary to the common perception and widely publicized statements , the overall risk of developing breast cancer decreases in women as they grow old.
Contrary to the expectations , shorter LTL was also associated with longer pre-ejection period , indicating lower sympathetic tone.
Contrary to the findings with MO-VEPs , SO-VEP parameters were significant predictors of average response times and diffusion model parameters.
Contrary to the healthy controls , right brain damage decreased ( but did not abolish ) spatial priming.
Contrary to the incidence of primary cancers , the incidence of brain metastasis has been increasing.
Contrary to the null hypothesis of measurement invariance , datasets for all three tests exhibit substantial differential responding.
Contrary to the right hemisphere ageing hypothesis , older participants showed no evidence of a relative right hemisphere decline in performance on the tasks.
Contrary to the time effects , no difference between groups was detected for any parameter at any time point.
Contrary to this , non-viable osteocytes accumulated centripetally around the inner ear space and accounted for @percent@ of all lacunae at @number@ years of age.
Contrary to this , we suggest that older adults' ; changing performance reflects memory search demands , which escalate as experience grows.
Contrastingly , GMV values of the left putamen and middle occipital gyrus were more strongly correlated with PS after 70years.
Contrastingly , in men , higher protein intakes lead to greater bone loss at the trochanter.
Contrasting with letters , ignored faces elicited larger N1 and N170 components than attended faces in both age groups.
Contrast sensitivity and BCVA were correlated ( r = @number@ ) , whereas straylight and BCVA were not.
Contrast sensitivity was evaluated at @number@ months.
Contrast sensitivity was evaluated by employing a Ginsburg Box , VSCR-CST-6500.
Contrast sensitivity was very similar in the age groups of 40-49 and 50-59 years.
Contrast-to-noise , heart rate dependence and B1 + dependence were also evaluated.
Contributing factors include full time faculty shortage , aging workforce , practice and student debt , practice and family commitments , and financial compensation.
Contributing factors include the aging population , tobacco abuse , obesity , and diabetes , all of which increase the prevalence of cardiovascular diseases.
Contributing factors may be improved risk assessment and screening techniques ( especially of dense breast tissue ) , delayed childbearing , and the aging population.
Contributing factors to disparities in frailty were also examined.
Contributing to these GWAS efforts , we performed genotyping of previously identified risk alleles in PD patients and control subjects from Greece.
Contributing to this female-majority CVD mortality gap is a lack of awareness of CVD risk among women and their physicians.
Contribution of factors was modeled using population attributable risk ( PAR ) and odds ratios.
Contributions to international congresses on breast cancer in @number@ were also included.
Control among treated hypertensive participants was low , especially in Tirana and Natal.
Control and intervention groups completed assessments at baseline , @number@ and @number@ weeks.
Control and PreAD-1 performances on the experimental test were compared by controlling for age and education.
Control beliefs are perceptions about one's abilities or competence and the extent to which one can influence performance outcomes.
Control experiments indicate that the degraded performance cannot be explained by optical , retinal or other perceptual factors , but is cortical in origin.
Control explants from fellow eyes were cultured in medium only.
Control facilities employed usual advance care planning practices.
Control group caregivers received @number@ telephone calls and educational materials.
Control group received neither supplementation nor placebo.
Control groups either received usual care or other activities.
Control groups were assessed at pre- and post-test.
Control group was allocated to usual-care.
Control / intervention allocation was determined by geographic selection.
Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health.
Controlled logistic regression was used to determine the association of physical inactivity with these characteristics.
Controlled randomized trials are planned to assess TA-65®-specific effects in humans.
Controlled supplementation with Selenium could be a new strategy to protect skin against aging.
Controlled trials are needed to further clarify this relationship.
Controlled trials need to be carried out to determine whether pharmacological therapies can also be beneficial in addition to surgical treatment.
Controlling for age and sex reduced the mean difference to @number@ and controlling for risk factors further reduced it to @number@
Controlling for age , differences in health status ( EQ-VAS ) were found to be not significant in both groups.
Controlling for agency effect and general health at baseline , the general linear model was used to assess the significance of outcomes at @number@ weeks.
Controlling for APOE ε4 did not substantively affect the associations.
Controlling for baseline cognitive function , age , sex , education , diabetes , and hypertension , linear regression was performed.
Controlling for baseline Mini-Mental State Examination and sleep factors had little effect on our results.
Controlling for changes in PF , changes in absolute / relative alpha1 / 2 power and in absolute beta power were minor.
Controlling for cognitive functioning across all domains , individuals with higher estimates of brain reserve had significantly greater WMH volume.
Controlling for confounders , we assessed whether recessions experienced at ages 25-34 , 35-44 and 45-49 were associated with cognitive function at ages 50-74.
Controlling for demographic and functional characteristics , access to services remained significant.
Controlling for demographic differences , Internet use and self-efficacy remained significantly related.
Controlling for individual characteristics and time did little to change this relationship ; while a similar relationship between older age structure and functional limitations emerged.
Controlling for relevant maternal and infant characteristics strengthened the significance of the observed racial differences ( β = -0.12 ; P = .02 ) .
Controlling for sex and age , public ownership was associated with lower ED transfer rates compared to for-profit and non-profit ownership.
Controlling for socioeconomic status substantially contributes significantly to utilization.
Controlling for SUD , cardiovascular disease emerged as the most significant and frequently associated health problem for aging offenders.
Controlling for the adoption of an important nonmedical innovation also has little influence on the estimated effects of medical innovation adoption on life expectancy.
Controlling for time-varying sociodemographic and health conditions , levels and rates of change in physical and cognitive function did not differ according to TCM use.
Controlling microglial cell reactivity has important consequences for preserving adult neurogenesis , neuronal structure and function , and cognition.
Controlling the expression of these pathways could ameliorate human health.
Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance.
Control measures should be strictly enforced whenever increasing incidences of epidemiological unrelated strains were identified.
Control MGC803 cells were grown without acids or bile salts for @number@ weeks as a control.
Control monkeys ( n = 13 ) received water and an isocaloric maltose-dextrin solution.
Control of cellular aging and apoptosis by Zfra , p53 and WWOX is discussed.
Control of patient T cell trafficking is re-established by treatment with exogenous PEPITEM.
Control of the car was mostly similar for both groups.
Control of variability depended on the history of past rewards , with the largest trial-to-trial changes occurring immediately after an unrewarded trial.
Control panel prototype has been developed to provide explanation of the automatic diagnosis.
Control participants performed better on olfactory identification and showed lower PiB binding than aMCI patients.
Control participants receive a booklet on healthy ageing.
Control participants were given a control pedometer intervention that only tracked step counts for an equivalent period of time.
Control participants were recruited from a healthy community population based on a health investigation ( N = 119 ) .
Control patients received usual care , which may or may not have included alcohol counseling.
Control patients were only commenced on a MCP if referred by clinical staff.
Control rates concerned only @percent@ of women and @percent@ of men and decreased with age.
Control rates remain low , particularly in high-risk , older and diabetic individuals.
Control regions showed no associations.
Controls alive at age @number@ years.
Controls also declined significantly in PCS.
Control samples were from a population-based study of elderly Finnish individuals.
Controls included @number@ healthy , normo-ovulatory women not seeking treatment for fertility from a community-based cohort ( Ovarian Aging study ) .
Controls matched for age and sex were randomly chosen from the Population Register Centre of Finland.
Controls ( n = @number@ ) , frequency-matched on age and sex , were from the same area.
Controls ( n = @number@ ) had no fracture during follow-up.
Controls ( n = @number@ ) were subjects who did not develop lung cancer.
Controls ( n = @number@ ) without AMD were frequency matched for age , sex , and ethnicity.
Control specimens did not receive EDC treatment.
Control specimens were obtained from patients who underwent an operation for septoplasty or middle concha hypertrophy.
Controls , recruited from the same clinics , did not have significant vision loss.
Control subjects completed @number@ weeks of no exercise ( control ) followed by @number@ weeks of CT.
Control subjects ( n = 13 ) received no LMMS treatment.
Controls were matched to cases on age , date of serum collection and follow-up time.
Controls were more likely to have an ε4 allele ( Pearson χ ( @number@ ) = @number@ p = @number@ ) .
Controls were not differentially affected by the spatial frequency content of scenes.
Controls were selected among similar to demographic and hematologic characteristics of patients.
Controls were selected from other ENT patients , and were matched for hospital admission , week of disease onset , and climate conditions.
Controls were selected from pregnancy registries in the same areas.
Controls were subsequently restricted to active comparators.
Controls were those without PCa and had one or more testosterone measurements.
Controls without atrial fibrillation were randomly selected from the remaining @number@ patients using a 1 : 2 matching for sex , age and education.
Control tasks did not predict either aspect of well-being in either member of the dyad.
CONTROL : Usual care.
Controversial reports and the mechanistic insights regarding the roles of testosterone in insulin-resistant obesity and cognitive function are also presented and discussed.
Controversial results were found on multimorbidity and mortality risk.
Controversial results were reported for other functional measures.
Controversies concerning the possible caffeine influence on human physical and psychological health are briefly summarized and presented.
Controversy and context : two words that exemplified this year's International Society for Experimental Hematology meeting.
Controversy arises from contradicting data from numerous studies , which used different methodological approaches.
Controversy exists relative to the benefits versus risks of testosterone replacement therapy in men with testicular hypogonadism.
Controversy remains on the actual contribution of satellite cells to the development of sarcopenia in later life , this clearly requires further research.
CO ( @number@ ) R was calculated between EtCO ( @number@ ) ranges 30-40 and 40-50 mmHg.
Convenient access to transportation strongly affected ability to use resources.
Conveniently , IL-8 can be measured non-intrusively from urine.
Conventional and 2-dimensional speckle tracking echocardiography was performed to determine the presence of LV and RV ( biventricular ) dysfunction.
Conventional and unconventional follow-up initialed by HM results were analyzed.
Conventional care was provided to the conventional group ( n = 47 , mean age = 80.19±7.53 years ) during the same period.
Conventional clinical examinations were carried out.
Conventional cognitive assessment is based on a pencil-and-paper neuropsychological evaluation , which is time consuming , expensive and requires the involvement of several professionals.
Conventional discharge summaries do not adequately incorporate the elements specific to an aging clientele.
Conventional laser therapy treats entire surface areas by selective photothermolysis or ablation.
Conventional lateral cephalograms for cephalometric analysis were scanned and analyzed by Dolphin Imaging software @number@
Conventional longitudinal models did not adequately partition age-related changes from other time-dependent variables.
Conventional lumbar separation was performed by removing soft tissue and subsidiary structures , leaving only the vertebral body.
Conventionally , fracture repair is divided into defined stages , each characterized by a specific set of cellular and molecular events.
Conventionally regarded as minor , injuries from ground-level falls are now associated with a higher risk of death for elderly people.
Conventionally , sarcopenia is defined by muscle mass and physical performance.
Conventional measurements of anticoagulation during bypass poorly reflect this incomplete anticoagulation , and alternate methods may improve anticoagulant therapy.
Conventional methods of gene expression analysis have yielded important insights into AMD pathogenesis , but the precise molecular pathway alterations are still poorly understood.
Conventional MRI measures lack of pathological specificity and are weakly correlated with MS clinical manifestations.
Conventional pulsed-wave Doppler and tissue Doppler velocities were obtained both at rest and immediately after the end of exercise , respectively.
Conventional radiographs and CT will show the presence and localization of the fractures in the anterior and posterior pelvic ring.
Conventional risk factors are identified and treated with intensive pharmacotherapy.
Conventional risk factors such as aging , hypertension , diabetes mellitus , and smoking increase the risk for carotid atherosclerosis.
Conventional storage of blood-derived fractions relies on cold.
Conventional techniques rely on fat removal to contour the lower eyelid.
Conventional treatments , such as chemo- and radiotherapies , preferentially induce premature senescence instead of apoptosis in the appropriate cellular context.
Convergent activation to all presentation modes was observed in executive and chemosensory association areas.
Convergent and discriminant validities were tested using correlation analysis and t tests , respectively.
Convergent validity ( CV ) was provided by comparing BAM-COG scores to gold-standard paper-and-pencil and computer-assisted cognitive assessment.
Convergent validity was estimated at r = @number@ and adequate discriminant validity was also found.
Convergent validity was evaluated against the Mini-Mental State Examination ( MMSE ) .
Convergent validity was examined by calculating rank correlations between the self-tests and neuropsychological tests.
Convergent validity with the Free and Cued Selective Reminding Test was moderate.
Converging data from rodents and humans have demonstrated an age-related decline in pattern separation abilities ( the ability to discriminate among similar experiences ) .
Converging evidence from MRI and other imaging modalities suggest that this activity has an intrinsic neuronal origin.
Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease ( AD ) .
Conversation analysis was used to explore recurrent communicative practices associated with each diagnostic group.
Conversations about sensitive topics can be particularly challenging with geriatric patients , who experience functional and sensory limitations.
Conversely , 11β-HSD2 is a dehydrogenase , inactivating glucocorticoids.
Conversely , a female \ "fertility-frailty pleiotropy \ " might result in greater physiological reserves in women.
Conversely , after reading the print-based materials , the older adults felt more empowered to continue drive.
Conversely , age-dependent gain of Treg activity would result in failing immunity , such as the rising risk of malignancies and infections amongst the elderly.
Conversely , aging-associated functional decline caused by both cell-autonomous and non-cell-autonomous mechanisms is likely to reduce the fitness of stem and progenitor cell populations.
Conversely , a growing body of evidence , to be reviewed here , suggests that thymulin is a hypophysiotropic peptide.
Conversely , a higher SHC impact score was associated with poorer health preference.
Conversely , AKT induces rapid downregulation of miR-199a-5p to effect upregulation of hypoxia-inducible factor 1α and sirtuin @number@
Conversely , AKT induces rapid downregulation of miR-199a-5p to effect upregulation of hypoxia-inducible factor 1α Hif-1α and sirtuin @number@ ( Sirt1 ) .
Conversely , all negative social support from spouse , children , other family , and friends significantly strengthened the deleterious effect of MCC on depression.
Conversely , along with HSC trans-differentiation , CtsH and CtsL were progressively down-regulated , whereas HDAC4 was concurrently stabilized.
Conversely , among never-married or widowed older adults , being childless was associated with reduced domestic support but without differences in other support domains.
Conversely , anabolic treatments for osteoporosis enhance the work of the osteoblast by altering osteoblast metabolism.
Conversely , a neck was visible for only 24 / 34 aneurysms at 3D TOF-MRA.
Conversely , anticoagulant processes limit clot extension to unaffected portions of the vasculature.
Conversely , an upward trend in mortality rates was observed in Brazil.
Conversely , aortic stretch-related work represents stored energy that may facilitate early diastolic filling.
Conversely , APOE genotype , and VEGF polymorphisms were not associated with survival risk in the FTLD sample.
Conversely , autophagy regulates ciliogenesis by controlling the levels of ciliary proteins.
Conversely , blocking antibodies to α ( v ) β ( @number@ ) abolished the down-regulation of HAS2 and the cytoskeletal effects.
Conversely , cellular senescence constitutes a failsafe program against cancer progression.
Conversely , CID was found to generate quantitative MS / MS product ions only at the higher precursor charge state.
Conversely , cognitive load does not perturb the realization of a new complex postural task.
Conversely , controlled ROS production has been recognized as an integral part of cellular signaling.
Conversely , deep cortical WMH was only associated with cardiovascular mortality ( @number@.92-fold , @percent@ CI , @number@ @date@ ) .
Conversely , depression and disability were associated with decreases in hippocampal volume.
Conversely , diabetes was significantly more prevalent among MA men and women compared with their NHW counterparts.
Conversely , dietary potassium intake attenuates these effects , showing a linkage to reduction in stroke rates and cardiovascular disease risk.
Conversely , disruptions in sleep consolidation seem more stable across age.
Conversely , ectopic expression of dPGAM5 exacerbated the dPINK1 and Drosophila parkin ( dParkin ) phenotypes.
Conversely , ectopic expression of PIM-1 resulted in premature senescence.
Conversely , ectopic overexpression of Prom1 inhibited mTORC1 and mTORC2 activities , and potentiated autophagy flux.
Conversely , EGFR , like Bcl-2 and p53 , was significantly up-regulated in tumors from elderly patients.
Conversely , elderly patients are more predisposed to oral conditions due to age-related systemic diseases and functional changes.
Conversely , excess zinc added to the medium has shown to potentiate the stimulation of autophagy by tamoxifen , H2O2 , ethanol and dopamine.
Conversely , few studies have examined the case of healthy elderly people not living alone.
Conversely , flatfoot deformity may be a predisposing factor for the onset of PTT dysfunction.
Conversely , for the genes only a limited set of GO terms and canonical pathways were identified.
Conversely , genetic inhibition of autophagy induced significant mitochondrial function defects.
Conversely , good performers maintained sensitivity in both visual fields in response to R-atDCS , although this effect was small.
Conversely , hippocampi from Cav-1 knockout ( KO ) exhibited decreased expression of DISC1 and proteins involved in synaptic plasticity.
Conversely , in countries with an altered health system , a minor increase in new cases of this disease is recorded.
Conversely , inhibition of APP palmitoylation by pharmacological inhibitors reduced APP-dimerization in coimmunoprecipitation and FLIM / FRET assays.
Conversely , inhibition of miR-216a in old HUVECs rescued the ability to induce a protective autophagy in response to ox-LDL stimulus.
Conversely , in high CR patients only , WMLs ( but not MTA ) highly contributed in increasing the risk for conversion to AD.
Conversely , in men living alone the intake of fruits and vegetables was significantly lower.
Conversely , in the AD sample , mean estimates generally underestimated differences in brain volume at percentile ranks above the mean.
Conversely , in the DLB pathology-free cerebellum , lower genomic content of rDNA was present in the DLB group.
Conversely , in the high cognitive load condition , we observed significant age differences in the Stroop effect in both the nonnoise and noise conditions.
Conversely , it has been proposed that regular exercise plays a protective role , attenuating the impact of age on vascular and metabolic physiology.
Conversely , it is now evident that ageing is a biological process tightly controlled by evolutionary highly conserved signalling pathways.
Conversely , left hippocampal volume was associated with both verbal learning and recall.
Conversely , mean serum levels of adiponectin were significantly lower in patients with psoriasis than in controls ( P < @number@ ) .
Conversely , medical care related to women's health focuses mainly on maternal health and cancer prevention.
Conversely , mice with liver-specific overexpression of PKCδ developed hepatic insulin resistance characterized by decreased insulin signaling , enhanced lipogenic gene expression , and hepatosteatosis.
Conversely , midlife migrant women were not statistically different from U.S.-born women in years spent disabled.
Conversely , miscarriage rate was higher for patients in the control group ( P < 0.05 ) .
Conversely , MPD dilation might represent a normal age-related variant or , alternatively , an effect of chronic low-level alcohol consumption. and IAP.
Conversely , NE intervention did not significantly change resting and exercise erythrocyte rheological properties.
Conversely , neither of the other two groups exhibited any change in D1 inhibition after practising the co-contraction task.
Conversely , neural response in the visual cortex and cerebellum was observable across all emotional conditions.
Conversely , no age-related decline in proactive inhibitory control was observed.
Conversely , no association between PA and SES or parental SES was found for pre-school , school-aged children and adolescents.
Conversely , no changes in connectivity within the somatomotor and visual networks , networks implicated in primary information processing , were observed.
Conversely , no cognitive measure was significantly related to olfactory performance in naMCI.
Conversely , no significant associations were observed between prospective memory and quality of life in the @number@ participants without IADL problems.
Conversely , no significant association was detected with lacunar volume , number of microbleeds or BPF.
Conversely , no significant declines in positive emotion were evident among widowed persons with greater preloss trait resilience or greater marital strain.
Conversely , no significant differences could be observed between women aged < @number@ yrs and the elderly patients.
Conversely , no significant differences in polyQ repeat lengths were found between the ADPD patients and the controls for the other @number@ genes.
Conversely , obese mice exhibit increased soluble IL-6R levels in the cerebrospinal fluid.
Conversely , one study reported no interactions between CFH and ARMS2 risk alleles and response to supplements.
Conversely , only in young participants was the MEP size modulated when the M1 and homolateral parieto-occipital cortices were coupled in the delta band.
Conversely , overexpression of DBC1 results in a decrease in PEPCK mRNA and protein levels.
Conversely , overweight , low to moderate drinking , high educational level , and living alone were associated with decreasing frailty.
Conversely , oxytocin administration had limited effects on social cognition in healthy participants.
Conversely , parents who view giving support to be highly stressful had higher levels of depressive symptoms when they gave low amounts of nontangible support.
Conversely , patients with a history of mood disorders are at higher risk of developing cognitive impairment.
Conversely , patients with weaker grip strength had lower PEFR and SVC.
Conversely , people who only prayed had higher odds of depressive symptoms than non-religious people @number@ ( @percent@ CI @number@ @number@ ) .
Conversely , pharmacological inhibition of BACE1 in CHO cells expressing human contactin-2 and mouse primary neurons decreased soluble contactin-2 secretion.
Conversely , pharmacologic AMPK activation attenuates catabolic responses to biomechanical injury , suggesting a potentially novel approach to inhibit OA development and progression.
Conversely , Pot1a overexpression or treatment with POT1a protein prevents DDR , maintained self-renewal activity and rejuvenated aged HSCs upon ex vivo culture.
Conversely , processes linked to normal aging , such as the increase in oxidative stress , might be relevant to the pathogenic mechanisms of HGPS.
Conversely , promising anti-aging strategies aim at inhibiting the mTOR pathway and thereby activating autophagy , to counteract aging associated damage.
Conversely , recent data suggest that IGF-I may contribute to amyloid neurodegeneration underlying Alzheimer's disease.
Conversely , reducing pch-2 expression with RNAi shortens worm lifespan.
Conversely , regular physical activity ( HR = 0.74 ) was associated with higher chance of survival.
Conversely , repeated TCR stimulation led to defective signaling and DUSP4 overexpression in control CD4 ( + ) T cells.
Conversely , ROCK inactivation with Y-27632 abolished their interaction , concomitant with ROS reduction.
Conversely , sigma and beta activity were more represented during SOREMP compared with the nocturnal REM period in patients with NT1.
Conversely , silencing of endogenous miR-22 led to decreased cell senescence , increased proliferation and migration , and improved angiogenesis.
Conversely , SIRT1 promotes FoxO1-driven SIRT1 autotranscription through interacting with and deacetylating FoxO1.
Conversely , skin and wound problems are highly reported among hospitalized elderly patients and caregivers.
Conversely , S. mutans showed significantly higher levels in HC than CF subjects ( p < 0.001 ) .
Conversely , spiritual care was either absent ( three ) or minimal ( three ) in CPGs.
Conversely stimulation of autophagy alleviates motor neuron degeneration.Therefore , autophagy represents an important target when developing novel treatments in ALS.
Conversely , subclinical hyperthyroidism was more prevalent in the EMAS cohort ( @number@ vs. @percent@ , P < @number@ ) .
Conversely , subjects with amnestic mild cognitive impairment ( aMCI ) do not exhibit overt involvement of cognitive domains other than memory.
Conversely , sufficient sleep ( 7-8 h / day ) and having a hobby were significantly associated with increased HRQOL.
Conversely , that timing was stable during the HS1S2 practice.
Conversely , the degree of nuclear cataract ( P = @number@ ) was not significantly associated with SFCT after adjusting for age and sex.
Conversely , the deletion of Kiaa0319 in neurons increased neurite outgrowth in vitro and improved axon regeneration in vivo.
Conversely , the dominant forms of acute leukemia affecting children associate with the lymphoid lineages.
Conversely , the nonamnestic subtypes were more likely to have increased vascular risk and to be African American.
Conversely , the NPI decline was observed whatever the CDR level.
Conversely , the number of joints with synovitis can be underestimated compared with young patients , and regular ultrasound assessment should therefore be considered.
Conversely , the older participants had lower amplitude submental EMG activity during non-stimulated swallows ( p = @number@ d = @number@ ) .
Conversely , the older participants scored significantly lower than the younger participants on the physical health scale.
Conversely , the opposite occurred in the proximal PAS region.
Conversely , the positive rate of MP increased with the age growing ( χ ( @number@ ) = @number@ P < @number@ ) .
Conversely , there is evidence that type @number@ diabetes may alter the progression and expression of sleep-disordered breathing.
Conversely , the relative poverty estimates increased when adjusting for confounders.
Conversely , there was no difference ( > @number@ ) in the percentage of Choice and Select samples rated as acceptable for all palatability traits.
Conversely , the sense of self can be strengthened with the support from others.
Conversely , the time spent in breaks in sedentary time was negatively associated with frailty.
Conversely , the total number of medications and xerogenic medications do not influence xerostomia.
Conversely , thyroid hormones have been suggested to enhance production of inflammatory cytokines.
Conversely , to examine the influence that walking has on executive functions involving visuospatial processing.
Conversely , total ghrelin is decreased after an oral glucose tolerance test in all ages , with the exception of neonates.
Conversely to TGA , TEA have a shorter duration , is recurrent but have a clear-cut response to antiepileptic drugs.
Conversely , T supplementation has been suggested for depressive syndrome in young and ageing men.
Conversely , UA also appears to function as an antioxidant and may protect against the oxidative stress associated with aging and disease.
Conversely , unbound iron can catalyze oxidation of lipids , proteins , and DNA.
Conversely , UPSA-B scores were unrelated to participant-reported cognitive difficulties on the POMS Confusion / Bewilderment subscale.
Conversely , verbal fluency at age @number@ was significantly , positively related to Intellect at age @number@
Conversely , warmth did not rely on these executive or verbal skills , but covaried primarily with patients ' capacity for emotional responsiveness.
Conversely , we found that dramatically shorter lifespans evolved when mating costs were relatively low and food was relatively scarce.
Conversely , Δ133p53 knockdown or p53β overexpression in CD8 + CD28 + cells inhibited cell proliferation and induced senescence.
Conversion of normal weight to overweight status predominated in urban area , private schools and boys.
Conversion of normal weight to underweight predominated in rural area , government schools and boys.
Conversion of underweight to normal weight predominated in urban area and girls.
Conversion risk from MCI to AD could be estimated as a function of age , time interval between examinations , and hypertension.
Co-occurrence of FI and UI was @percent@.
Coodetec @number@ and BRS @number@ cultivars were studied.
Cooking losses were determined and proximate analyses ( moisture , fat , nitrogen and ash ) were performed.
Coolness here is understood as both a socio-cultural resource and an individualized habitus of everyday living.
Coordinated activation of muscle stem cells ( known as satellite cells ) is critical for postnatal muscle growth and regeneration.
Coordinated and constructive physical activity is correlated with the maintenance of cognitive function in humans.
Coordinated , multi-disciplinary efforts across multiple chronic diseases may provide opportunities for synergistic effects.
Coordinated , team-based cancer care will be essential to ensure value-based care.
Coordinates were extracted from clusters with significant difference in FA between ALS patients and HC.
Coordination and balance exercises are important in an individual workout program.
Coordination as part of the stabilization process of joints is compromised in older adults.
Coordination of energy metabolism is essential for homeostasis of stem cells , whereas an imbalance in energy homeostasis causes disease and accelerated aging.
Co-overexpression of HOX and TALE genes , particularly the HOXA cluster and MEIS1 , is associated with AML.
COP-COM distances in the older group were significantly reduced during the accelerated phase , then significantly increased during the decelerated and steady phases.
CoP composite scores in ML direction were consistently higher for all standing conditions in old compared to young participants ( p < @number@ ) .
COPD ( Chronic Obstructive Pulmonary Disease ) is a respiratory disease characterized by progressive and largely irreversible airway limitation and extrapulmonary problems.
COPD emerged as a significant predictor of falls despite affecting a smaller proportion of respondents.
COPD increases health care resource utilization and spending and adversely affects quality of life.
COPD is associated with several comorbidities ( multimorbidity ) , such as cardiovascular and metabolic diseases , that share the same pathways of accelerated aging.
COPD is characterized by a poorly reversible airflow limitation resulting from chronic inflammation , mainly due to tobacco exposure.
COPD is especially prevalent in the elderly , affecting @percent@ of those aged > or = 75 years.
COPD is more frequent in males and in rural areas.
CoP displacement was the main outcome measure.
COPD is recognized as having a series of comorbidities potentially related to common inflammatory processes.
COPD mortality is much more closely related to the prevalence of a low forced vital capacity which is , in turn , associated with poverty.
COP during static standing was measured.
Coping and social motives were associated with greater consumption , and higher positive affect was associated with lower consumption.
Coping practices were grouped into five themes : resist , adapt , substitute , endure , and eliminate.
Coping strategies and health locus of control can be changed by cognitive behavioral interventions.
Coping strategies included reimagining and revaluing various aspects of the self through assimilating new activities and reprioritizing others.
Coping was the most commonly expressed motive.
Coping with negative affect and enhancement of positive affect have been shown to be associated with high levels of alcohol consumption and alcohol-related problems.
Coping with stress is fundamental for mental health , but understanding of the molecular neurobiology of stress is still in its infancy.
Copious hypotheses have been proposed to explain the mechanisms of aging , but no single theory is generally acceptable.
Copper and selenium do not seem to play any significant role in the occurrence of TT deficiency in aging men.
Copper deficiency is associated with optic neuropathy , but retinal function is maintained.
COP sway area showed a greater increase with fatigue in older adults when standing on the CS.
COP translation was more influenced by receding flow during QS and by approaching flow during SIP.
Copyright © @number@ John Wiley & Sons , Ltd.
Copyright © @number@ John Wiley & Sons , Ltd.
Copyright © @number@ John Wiley & Sons , Ltd.
Copyright © @number@ John Wiley & Sons , Ltd.
Copyright © @number@ John Wiley & Sons , Ltd.
Copyright © @number@ Pathological Society of Great Britain and Ireland.
Copyright © @number@ Pathological Society of Great Britain and Ireland.
Copyright © @number@ Pathological Society of Great Britain and Ireland.
CoQ10 as a therapy appears to be safe and well tolerated.
CoRAL is available at @url@
Cord blood of ART-exposed infants exhibited TL shorter than that from infants born to HIV-negative mothers.
Cord blood was collected.
Cordycepin , an active ingredient of the insect fungus Cordyceps spp. , shows strong antioxidant and anticancer activities.
Cordycepin is widely used as for its various pharmacological activities , such as anti-inflammation , anti-angiogenesis , anti-aging , anti-tumor and anti-proliferation.
Coreceptor tropism based on HIV-DNA gp120 genotyping was also available within the past @number@ months.
Core features of the healthy microbiome might be defined and targeted to prevent disease and optimize human health.
Coregistered 3D MPRAGE sequence was used to eliminate from hippocampal and cortical regions of interest all voxel with < 75% of gray matter.
Coregistration of neuroimaging and cytoarchitectonic features can add value to help establishing functional architectonics of the PPN and facilitate neurosurgical targeting of this extended nucleus.
Co-relation factors were @percent@ for women and @percent@ for men ( p < 0 @number@ ) .
Core proteins of the NER pathway , XPD and XPA , and the lesion binding protein , XPC , are involved in limiting L1 retrotransposition.
Coresidence was more likely for those with a close relationship with the mother.
Co-residing with a child and having a high quality of contact were protective of both depressive symptoms and suicidal thoughts.
CoRIS is an open , prospective , multicenter cohort of HIV adults naive to HAART at entry ( @date@ to @date@ ) .
Cornea and limbus were imaged with OCT.
Cornea is the most important refractive medium of the eye and affects its total aberration state.
Corneal astigmatism and corneal shape factors were measured by the Scheimpflug-based Pentacam.
Corneal astigmatism was mirror symmetry in both eyes of one person.
Corneal biomechanical properties of hysteresis and resistance factor are significantly influenced by IOP , CCT , corneal radius of curvature , and AL.
Corneal densitometry increases with age , but corneal keratometry and refractive parameters do not affect light scattering in the human cornea.
Corneal densitometry was expressed in standardized grayscale units ( GSU ) .
Corneal epithelial cells activate in response to injury via mechanisms similar to those induced in Schwann cells during Wallerian Degeneration.
Corneal epithelial cells phagocytize distal axon fragments within hours of ICN crush wounds.
Corneal ET ( CET ) was obtained automatically by the built-in analysis software of the OCT system.
Corneal indentation pulse was measured with a noninvasive ultrasonic distance sensor.
Corneal inlays are a relatively new treatment modality that is effective at compensating for presbyopia.
Coronal lesions tend to be around existing restorations where there is no evidence base about care / prevention.
Coronary and thoracic plaques were categorized as calcified , mixed , or non-calcified.
Coronary angiography , performed on an emergency basis , in both cases revealed minimal luminal irregularities , with no evidence of plaque rupture or thrombus.
Coronary artery calcification ( CAC ) is a heritable and definitive morphologic marker of atherosclerosis that strongly predicts risk for future cardiovascular events.
Coronary artery calcium ( CAC ) is a validated subclinical measure of atherosclerosis.
Coronary artery calcium ( CAC ) was measured by cardiac computed tomography.
Coronary artery disease ( CAD ) and calcification score were assessed using computed tomography angiography.
Coronary artery involvement is the most important complication of Kawasaki disease and may cause significant coronary stenosis resulting in ischemic heart disease.
Coronary collaterals are present at birth , with wide interindividual variation in their functional capacity.
Coronary death and nonfatal myocardial infarction were ascertained from medical screenings every @number@ years , hospital data , and registry linkage.
Coronary heart disease ( CHD ) is the leading cause of death worldwide.
Coronary heart disease ( CHD ) is the leading cause of morbidity and mortality in the western world.
Coronary plaque characteristics were analyzed on a per-segment basis according to the modified AHA classification.
Coronary spasm was thus significantly reduced in the pioglitazone group compared with the control group ( P = 0.011 ) .
Coronary vessel distensibility is reduced with atherosclerosis and normal aging , but direct measurements have historically required invasive measurements at cardiac catheterization.
Corpora amylacea ( CA ) are glycoprotein-based depositions that accumulate in the normal aging brain or consecutively to different neuro-degenerative diseases.
Correct filler placement at different areas of concern is important to achieve desired and natural results.
Correcting these disorders may aid in removing possible causes of CTS.
Correcting this mutation in human embryos may prevent the disease being passed onto future generations and cure anemia.
Correctional facilities have become a front line for mental health care.
Correctional health research requires important safeguards to ensure that research participation is ethically conducted.
Correctional health systems must adapt to address the evolving epidemiology of HIV among inmate populations.
Correction of the nasojugal groove with a Restylane Vital® injector causes minimal tissue trauma and allows exact placement of hyaluronic acid.
Correction of these deficits could improve the quality of life in this population.
Correction of the skeletal framework is increasingly viewed as the new frontier in facial rejuvenation.
Correction was maintained for at least @number@ months , with no adverse events.
Correct policy making and determination to eliminate the concerns from this vulnerable population in Japan are necessary for healthy aging.
Correct RNA editing is an indispensable factor of an organism's development and probably determines the lifespan of higher eukaryotes.
Correlates of clinical protection may not be measured using standard techniques such as antibody titres to predict vaccine efficacy.
Correlates of retirement saving behaviors have yet to be fully understood.
Correlates of sarcopenia identified in this study might suggest new approaches for prevention and treatment of sarcopenia.
Correlational analyses and analysis of variance were used to evaluate the association between each scale and to compare scoring time.
Correlational analyses were then performed for the neurochemical and cognitive data.
Correlational analyses will be used to investigate possible associations between volition , maximal oxygen uptake , physical activity level and weight loss maintenance.
Correlational analysis between the subscale scores representing such factors and the serum hormone profiles was also performed.
Correlational and mediation analyses were used to test the potential mediating effects of health-related behaviors on the associations between personality and integrity.
Correlation analyses among the measures and regression analyses of objective and subjective QOL measures ( QLS and LQLP ) were conducted.
Correlation analyses between the findings and patients ' age and visual acuity were performed.
Correlation analyses examined associations between age and tendon thickness.
Correlation analyses showed significant relationships between frailty , self-management abilities and poor health.
Correlation analyses were performed between age and relative improvement in performance.
Correlation analyses were performed between all measured variables to establish the relationships among them and their variation with age.
Correlation analysis revealed positive relationships between HSP70 levels and zymosan-stimulated ROS production in the elder group.
Correlation analysis revealed several statistically significant correlations between ' t ' or ' p ' and antero-posterior cephalometric variables.
Correlation analysis revealed that the steady state UPE only from the buttock was related to skin elasticity , which showed age-dependent changes.
Correlation analysis was completed using a Pearson correlation coefficient.
Correlation analysis was conducted between serum creatine kinase levels ( roughly estimate of disease state ) and the clinical features.
Correlation analysis was performed and in multiple regression analysis we used BP values as the dependent variable and fat percentage and age as independent variables.
Correlation analysis was performed between the optical intensities in each layer and image quality and subject's age.
Correlation analysis was performed to investigate the association between regional CBF and cognitive or mobility performance over the 2-year span.
Correlation analysis was used for data description.
Correlation analysis was used to analyze the correlation between the age and retinal MS values.
Correlation and multiple linear regression analyses adjusted for age , depressive symptoms and body composition were performed.
Correlation and multiple regression analyses were performed to identify factors independently associated with each measure.
Correlation and regression analyses were performed and the numbers of correct intubation trials recorded.
Correlation and regression tree analyses were performed and predictive capacities were assessed.
Correlation between chronologic age and MR bone age was determined by means of simple linear regression analysis.
Correlation between concentrations of elements in fingernails is calculated.
Correlation between FD and clinical measures suggests that FD could potentially serve as a biomarker of ALS pathophysiology , especially after confirmation by longitudinal studies.
Correlation between MTHFR genotypes and lipids was then evaluated.
Correlation between neurite density index ( NDI ) and neuropsychological performance was assessed in @number@ white-matter regions of interest.
Correlation between smell and taste alterations , age , and previous adjuvant treatments in laryngectomees was investigated.
Correlation between vBMD and age was statistically significant ( r = 0.15 , P less than @number@ ) .
Correlation , Bland-Altman and Sheiner & Beal methods were used to validate and compare the PEs against dual X-ray absorptiometry ( DXA ) -derived LBM.
Correlation coefficients were also determined between the dynamic diameters and age , body surface area , weight , and height.
Correlation coefficients were much greater in women than in men.
Correlation maps selected a seed region in the combined bilateral precuneus.
Correlation results indicated that previous falls , falls efficacy , mobility , SRH and depression and well-being were all inter-related.
Correlations among low-frequency spontaneous fluctuations in the blood oxygen level-dependent ( BOLD ) signal reflect the connectivity of intrinsic large-scale networks in the brain.
Correlations among muscle parameters including skeletal muscle density and intermuscular adipose tissue using mid-thigh CT scans were assessed.
Correlations and linear multiple regression ( LMR ) between %Hyper , %Nitro , microcirculatory parameters , oxidative stress and inflammatory biomarkers were investigated.
Correlations between ADMI from seafood and blood Hg levels were stronger among Asian WORA than among Non-Asian WORA.
Correlations between age and the physical performance and body composition parameters were tested.
Correlations between clinical symptoms of osteoporotic vertebral fractures with intravertebral cleft and radiographic findings were investigated.
Correlations between CR and WM integrity were adjusted for age , gender , memory performance and brain volumes.
Correlations between CSF analyte levels were performed with neuropsychological measures and the Clinical Dementia Rating scale sum of boxes ( CDRsb ) .
Correlations between DMN and cognitive performances were also tested.
Correlations between error-monitoring variables and neuropsychological tests of executive functioning and language were performed.
Correlations between histopathology and hearing phenotype were investigated.
Correlations between insulin resistance parameters , age of patients , disease duration , and stages of AGA in males and females revealed nonsignificant differences.
Correlations between masticatory ability and each test were examined using Spearman rank correlation coefficients.
Correlations between MHR and age or gender , albeit significant , showed the effect magnitude had little statistical relevance.
Correlations between MVPA and DLW-determined PAEE were lower , particularly for modified bouts of ≥10 min.
Correlations between peak torques and torque variability differed between males and females and between age groups in certain cases.
Correlations between self-reported allergic conditions and urbanization remained statistically significant in multivariate logistic regression tests.
Correlations between strength and size of the toe flexor muscles of the pooled group ( n = @number@ ) were also calculated.
Correlations between the CogState and neuropsychological tests ranged from @number@ to @number@
Correlations between the frequency powers of EIG and fMRI signals during 30min of rest were then examined to elucidate gut-brain interactions.
Correlations between the perfusion characteristics and the individual / occupational factors were analyzed using the Spearman test.
Correlations between the photo-signals and volunteer age were calculated.
Correlations between the relative and absolute concentrations for each fatty acid were used to measure agreement.
Correlations between the short BBS and static and dynamic balance were analysed by Spearman's correlation analysis.
Correlations between the two measures were in the expected directions proving modest evidence for their convergent validity.
Correlations between TL and clinical features were examined and multiple linear regression analysis was performed to investigate potential predictors of TL.
Correlations between TRM from blood and buccal DNA were obtained and also between the same blood DNA samples measured in separate laboratories.
Correlations exist between parameters characterizing aortic elasticity and parasympathetic autonomic function , as shown by standard cardiovascular reflex tests in healthy volunteers.
Correlations for steps per day and accelerometer-estimated PAEE with DLW-determined PAEE were similar.
Correlations in activity across disparate brain regions during rest reveal functional networks in the brain.
Correlations of choroidal thickness at each location with age , refractive error , and axial length were analyzed.
Correlations of @number@ to @number@ were observed between the sense of authenticity and mental health in all age groups.
Correlations of performance with age were also significant when analyses were restricted to just the young and middle-aged adults.
Correlations of serum levels of glucose , total cholesterol , and triglycerides with APOE genotypes were assessed.
Correlations of water content with HA , tsGAG , and tUA were found in epidermis , but not with tsGAG in dermis.
Correlation structures were compared before treatment and after @number@ and @number@ weeks of treatment.
Correlation study revealed moderate correlations between HSDI-derived parameters and conventional acoustic or aerodynamic parameters.
Correlations were also examined between changes in arterial stiffness and baseline arterial stiffness values.
Correlations were determined using univariate and multivariate regression analyses.
Correlations were evaluated between the instrumented standing balance and instrumented TUG measures and self-reported walking and balance performance , fall history , and clinical disability.
Correlations were moderate to good for pigmented spots and telangiectasia ( ρ = @number@.60-0.75 ) .
Correlations with immunohistochemical , clinical and outcome features were evaluated.
Correlations with mechanical performance for collagen cross-linking , crystallinity , and carbonate content are contrasted with mineral content.
Correlations with other measures of symptom bothersomeness , sexual function , depression , and anxiety conformed to hypotheses.
Correlations with short-term memory capacity and executive control tasks suggested an association with memory encoding and / or overall cognitive control deficits.
Correlations with WM within each age group were reduced for PM tasks that had more regular or focal cues.
Correlation was highly significant ( p > @number@ ) between refractive error and the aperture of the chamber angle as measured from OCT.
Correlative analyses between age and mean SUV of aortic segments in all subjects were undertaken.
Correspondence was scored on characteristics of dementia , a procedure was used to diagnose without including the MMSE score.
Corresponding bioinformatics strategies , as well as application in biological and clinical studies are presented.
Corresponding costs were calculated applying a societal perspective.
Corresponding figures for formal care users were @number@ hours in small municipalities , @number@ in mid-size municipalities and @number@ in urban areas.
Corresponding figures for period two were @number@ @number@ and @percent@ for males and @number@ @number@ and @percent@ in females.
Corresponding ICC for test-retest reliability were @number@ @number@ @number@ and @number@ @number@ @number@
Correspondingly , a strong susceptibility for age-related degeneration has been observed in the fronto-striato-thalamic network.
Correspondingly , imaging studies showed decreased activity of the amygdala and cortical face processing regions in response to emotional faces.
Correspondingly , many surgical interventions are undertaken and pathological specimens submitted for histopathologic workup.
Correspondingly , mTORC1 inhibitor rapamycin blocked the effect of BMP2 on NPC cell proliferation and invasion.
Correspondingly , only @number@ % of blindness and @number@ % of visual impairment were caused by DR in East Asia.
Correspondingly , partially distinct distributions of autoradiographic labelling of Alzheimer's disease slices with 11C-PBB3 and 18F-AV-1451 were noted.
Correspondingly , sestrin deficiency or simultaneous inhibition of all three MAPKs enhanced vaccine responsiveness in old mice.
Correspondingly , simulated diameter and wall thickness increased by about @number@ and @percent@ , respectively.
Correspondingly , the motility activity of KIF5A also decreased.
Correspondingly , the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies.
Correspondingly , the ratio of p-tau to t-tau was significantly reduced in ALS ( p < @number@ ) .
Correspondingly , they place less emphasis on daily emotional experiences.
Corresponding NLS values from the drinks per day model were @percent@ , @percent@ , @percent@ , and @percent@ , respectively.
Corresponding numbers for specialist services were @percent@ in men and @percent@ in women , where the majority was out-patient consultations.
Corresponding plasma concentrations of MASP-1 , MASP-3 , and MAp44 were measured.
Corresponding results demonstrate that the proposed approach could potentially achieve substantial gains over traditional FLMs.
Corroborating evidence from other exome array studies and gene expression data points toward potential involvement of these genes in the pathogenesis of AD.
Corroborating previous literature , results revealed that mindfulness disposition and perceived stress were negatively correlated in both groups.
Corrosion in metallic orthodontic attachments releases metal ions , mainly iron , chromium , and nickel.
Cortex growth is linear throughout life.
Cortex thickness was determined from the distance between the @number@ mg nuclear boundary and the capsule.
Cortical AChE activity showed a significant decline in MCI patients compared with controls which was most pronounced in temporal regions.
Cortical and cancellous bones from human tibias were glycated in vitro using either glucose ( glucosylation ) or ribose ( ribosylation ) .
Cortical and nuclear cataracts showed differential G3PD inactivation in the cortex , implying those @number@ type of cataracts might be formed through different mechanisms.
Cortical bone histomorphometry was performed with low ( ×50 ) and high magnification ( ×100 ) .
Cortical bone porosity is a major determinant of strength , stiffness , and fracture toughness of cortical tissue.
Cortical density and thickness as well as total and trabecular density increased with higher bio-17β-E2 levels.
Cortical development generally correlates with body growth.
Cortical disconnection may thus contribute to the declines in some aspects of cognitive functioning observed in healthy aging.
Cortical dynamics were examined during a cognitive-motor adaptation task that required inhibition of a familiar motor plan.
Cortical EEG sources were estimated using low-resolution brain electromagnetic tomography.
Cortical excitability was assessed during an antero-posterior perturbation by conditioning the H-reflex with single-pulse transcranial magnetic stimulation.
Cortical glucose hypometabolism accompanies WM FA alterations with a concordant pattern of gray and WM involvement in the parietooccipital lobes in DLB.
Cortical gray matter and white matter MTI parameters decreased with increasing chronological age ( all p < @number@ ) .
Cortical leaks were uniformly more frequent in the transgenic animals than in age-matched controls.
Cortical metabolic activity was lower in the right lateral frontal cortex , orbitofrontal cortex , and bilateral temporal cortex in patients with delusions.
Cortical micro-architecture was determined using AUTO and MOD contour methods.
Cortical motor threshold of the abductor pollicis brevis muscle , intracortical inhibition and facilitation were measured.
Cortical opacities are due to changes in membrane permeability and enzyme function and shear-stress damage to lens fibres with continued accommodative effort.
Cortical plaque burdens in Tg2576 , APPSwePS1ΔE9 , and 5XFAD mice eventually far exceeded those measured in the human cohort.
Cortical reconstruction , volumetric segmentation and auditory pathway tractography were performed.
Cortical regions involved in the pitch reflex phenomenon are highly vulnerable targets of network disruption in Alzheimer's disease ( AD ) .
Cortical regions showing altered FC clustered in parietal and temporal cortex , areas known to be susceptible to AD pathology.
Cortical sources of resting state electroencephalographic ( EEG ) rhythms are abnormal in subjects with mild cognitive impairment ( MCI ) .
Cortical surface atlases play an increasingly important role for analysis , visualization , and comparison of results across different neuroimaging studies.
Cortical thickness and ReHo maps were calculated in @number@ unmedicated depressed patients and @number@ healthy controls.
Cortical thickness decreased remarkably with age as well , and only @percent@ of the baseline value remained in the oldest group.
Cortical thickness in the distal section was the thickest in the posterior medial and the thinnest in the anterior aspect followed by lateral aspect.
Cortical thickness in the hippocampus did not vary between hemispheres among APOE-4 allele carriers and non-carriers.
Cortical thickness may thus be a major determinant of hip fracture risk.
Cortical thickness was averaged across a published set of a priori brain regions to derive a measure known as the \ "AD signature. \ "
Cortical thickness was measured using the surface based method.
Cortical thickness was reduced bilaterally in DLB compared to controls in the pericalcarine and lingual gyri , cuneus , precuneus , superior parietal gyrus.
Cortical thickness was reduced only in the parahippocampal gyrus at all disease stages.
Cortical thinning was associated with lower cognitive performance as well as with estimated exposure to repetitive subconcussive head impact.
Cortical tremor significantly worsened and amplitudes of giant somatosensory evoked potential significantly increased with age in BAFME.
Cortical volumes and thickness were measured with a surface-based segmentation procedure ( @url@
Corticosteroid-binding globulin ( CBG ) was measured , and free cortisol concentrations were calculated.
Corticosteroids and non-steroidal anti-inflammatory drugs ( NSAIDs ) are frequently associated with immunomodulatory therapies to treat flu-like adverse effects.
Corticosterone ( CORT ) is an adrenal steroid that plays a considerable role in stress and anti-inflammatory responses.
Corticotropic NFT formation must therefore be either unrelated to NP formation , a temporally distinct process , or both.
Cortisol and ACTH levels in study population had different correlation behavior in relation to central and peripheral regulators for hormonal axes.
Cortisol and adrenocorticotropic hormone ( ACTH ) level raised in senior age group.
Cortisol and ( DHEAS ) levels were determined in serum to assess potential mechanisms.
Cortisol ( C ) and testosterone ( T ) were measured in salivary samples.
Cortisol dysregulation has been proposed to be involved in depression.
Cortisol , fat free mass , ( FFM ) and total body mass were not significantly different between groups.
Cortisol induced DNA damage and the production of RNS was further attenuated in the presence of an iNOS inhibitor.
Cortisol level in UWS and cortisol / DHEA ratio in UWS and SWS had negative correlations with severity of oral burning sensation significantly.
Cortisol levels were assessed throughout the session.
Cortisol levels were enhanced pre-imaging relative to during and post-imaging in both age groups , suggesting anticipatory stress and anxiety.
Cortisol was analyzed using enzyme immunoassay kits.
Cortisol-WM relationships were modest , as was the degree to which WM structure attenuated cortisol-cognition associations ( < 15% ) .
Corvis-derived IOP was on average @number@ ± @number@ mm Hg higher than cornea-compensated IOP , with large differences in patients with high-average IOP.
Corvis measurements were compared with measurements from @number@ participants older than @number@ years.
Corvis parameters showed poor correlation with CH and CRF obtained by ORA measurements.
Cosedimentation experiments showed that F-actin can be fully occupied with combination of these two proteins.
Cosegregation analysis revealed c.1834C > T was paternal and c.2923C > T was maternal.
Cosmeceutical ingredients capable of reversing sun-induced alteration are of particular benefit for men.
Cosmeceuticals are being used on children ; yet studies of cosmeceuticals in the pediatric population are limited.
Cosmeceuticals are intermediate products between prescription medications and cosmetics , available to consumers over the counter.
Cosmetic dermatology has moved beyond just applying the same techniques used for females onto males.
Cosmetic dermatology is continuing to see a dramatic increase in both procedures performed and technological advancements.
Cosmetic outcomes were encouraging and satisfying to most patients.
Cosmetic results and improvement of photoaging parameters are evaluated by means of a modified Dover scale.
COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing , and have a world-wide impact on promoting successful ageing.
Cost analysis outcomes included COPD-related and all-cause inpatient , outpatient , pharmacy , LTC , and total costs during the 12-month postindex period.
Cost and LOS were compared using t-tests and multivariate regression.
Cost and practicality were compared.
Cost containment and accessibility of ascertainment methods are enhanced by well-validated and reliable methods such as screening for cognitive impairment by telephone interviews.
Cost data on health care visits during @number@ were collected from the Cost Per Patient database.
Cost data should optimally be evaluated in conjunction with effectiveness and performance indicators.
Cost data were collected from agencies participating in the delivery of EnhanceFitness classes in South Florida.
Cost data were obtained from the Organization for Economic Cooperation and Development and the World Bank.
Cost-effectiveness was evaluated using the traditional incremental cost-effectiveness ratio ( ICER ) and the net benefit regression framework ( NBRF ) .
Cost-effective recruitment of older adult study participants is essential to geriatric research.
Cost-effective strategies to maintain healthy active lifestyle in aging populations are required to address the global burden of age-related diseases.
Costimulation increased 5-bromo-2'-deoxyuridine incorporation of T cells from @number@ ± @percent@ in control to @number@ ± @percent@ in costimulated cells.
Cost is not a determining factor as barrier to undergo surgery and patients with poorer education are less likely to undertake surgery.
Cost of interventions was important.
Cost , physical , and mental health assessment data reveal the cost-effectiveness and positive health measures of AIP.
Cost questionnaires were e-mailed to program coordinators from agencies participating in the delivery of EnhanceFitness classes.
Costs and MLHFQ scores in patients with or without hypertension , diabetes and renal impairment were compared.
Costs are reported in @number@ U.S. dollars.
Cost savings associated with prescribers ' behavioral changes were estimated at €108 million.
Cost savings or favorable cost-effectiveness were robust in sensitivity and scenario analyses.
Cost savings were seen as the most important factor regarding policy decisions.
Costs for medical services / procedures 1-year pre-index ( excluding indirect and long-term care costs ) were estimated using line-item provider-linked administrative data.
Costs included both out of pocket costs and those paid by Medicare and Medicaid.
Costs of male osteoporosis may have increased due to population aging and change of treatment patterns.
Costs of patients with stroke are increasing with prolonged survival and the aging population.
Costs per patient within @number@ months of therapy were € @number@ and € @number@ respectively.
Costs per recommended daily dose ranged from $ 0.07 to a maximum of $ 2.50 ( CAD $ ) .
Costs related to the delivery of the two services ( TELE and VISIT ) were calculated.
Cost studies applying a societal perspective , and full economic appraisals where appropriate are warranted.
Costs were assessed over a 1-month period.
Costs were computed using French and U.S. tariffs.
Costs were presented from the perspective of participating agencies.
Cost was cited by @number@ ( @percent@ ) subject as the main reason for not seeking surgery.
Cost-weighting and bagging techniques were investigated to address class imbalance.
Co-transfection of miR-339-5p with a BACE1 @number@'-UTR reporter construct resulted in significant reduction in reporter expression.
Cotransmitter composition shows considerable plasticity in development and aging , in pathophysiological conditions and following trauma or surgery.
Co-treatment of CAPE with PI3K inhibitor LY294002 or Bcl-2 inhibitor ABT737 showed synergistic suppressive effects.
Co-treatment with rhGH lowered the testosterone levels ( quantified using liquid chromatography-tandem mass spectrometry ) necessary to reach these lean mass thresholds.
Could the burden of chronic inflammatory disease have been a risk factor for atherosclerosis in these ancient cultures ?
Coumarin and its derivatives are widely employed as a fragrance in cosmetics and skin care products.
Coumarin was the permeant with the highest flux across the skin.
Counseling accompanied by printed materials appears to be effective in improving adherence to the Mediterranean diet , although the app does not increase adherence.
Counseling on PA and the Mediterranean diet was given to both groups.
Counselor responses fell into @number@ major themes : Assessment and Action , Client Characteristics , Services , Counselor Training and Preparedness , and Future Directions.
Counterintuitively , faster increases in human life expectancy could lead to slower population aging.
Counter-screening these compounds against a broad panel of potential CNS targets revealed they are highly potent and specific ligands of the sigma-2 / PGRMC1 receptor.
Counter to what had previously been theorized , many older men continued to emphasize primary control as important well into late life.
Counting deficits not only allows grades of frailty to be discerned but also provides insights into the complex problems of older adults.
Counting productivity-related costs , per-patient costs for FTD appear to be greater than per-patient costs reported for AD.
Countries in which many foreign home attendants work without specific legal entry programs should rethink their policies.
Countries that apply those policies and those that do not were then grouped by income status.
Countries were categorized according to their level of economic development to investigate global patterns of spending.
Countries were categorized by SDI quintiles to summarize results.
Countries with an increase in the ASDR due to all cancers were largely located on the African continent.
Country context had a differential impact.
Country of birth and current country of residence were each associated with frailty.
Country recommendations regarding LTC are prominent under the EU's European Semester.
Counts of NPs in several neocortical regions were also assessed.
Count-thresholds for low , moderate and vigorous PA are mostly based on absolute intensity.
Coupled damped linear oscillator models succinctly describe daily stress and negative affect in terms of developmental forces ( e.g. , velocity , acceleration ) .
Coupled with ever-increasing resource-constricted educational environments , doctoral programs are challenged to provide high-quality education with limited resources.
Coupled with functional and electrophysiologic modalities , TMS can provide insight into the mechanisms underlying healthy neurodevelopment and aging , as well as neuropsychiatric pathology.
Coupled with the global obesity epidemic and aging of the world's population , a perfect metabolic storm is brewing.
Coupled with their ability to cross-talk with p53 , FoxOs represent an important class of tumor suppressors in a variety of cancers.
Couples serving together were interviewed conjointly.
Couples use avoidant strategies to defend against worry about cancer and anticipated prostatectomy-related sexual changes.
Covalent DNA-protein crosslinks ( DPCs ) are toxic DNA lesions that interfere with essential chromatin transactions , such as replication and transcription.
Covariate-adjusted linear regression analyses were conducted for each hormone separately and after adjustment for other hormone levels.
Covariates included age and socioeconomic status.
Covariates included age at baseline , sex , and self-perceived physical and mental health.
Covariates included age , race , education , income , self-reported overall health , and marital status.
Covariates included age , race , sex , obesity , smoking status , and walking activity.
Covariates included age , sex , diseases , depressive symptoms , and cognitive function.
Covariates included age , sex , sensorimotor and cognitive measures , mood and medications.
Covariates included age , sex , socioeconomic status , smoking status , diabetes , and arthritis.
Covariates included country of origin , gender , education , time spent in the United States , recruitment cohort , and age at enrollment.
Covariates included demographic characteristics , cognitive functioning , personality traits , affective responses , and subjective health.
Covariates included demographic characteristics , comorbid conditions , cognitive function , social support , and health behaviors.
Covariates included demographic variables , menstrual bleeding problems , body mass index , hormone levels , and self-rated health , also assessed at baseline.
Covariates included educational level and use of tobacco.
Covariates included pain , dementia severity , depression , insomnia and other sedative use.
Covariates included potential medical , demographic , and otologic confounders.
Covariates included social support , social isolation , comorbidities , and demographic measures.
Covariates included sociodemographic factors , baseline health , depressive symptoms , impairment of mobility and health behaviours.
Covariates , inherent sociodemographic and health indicators and comorbidities were also included in the analysis.
Covariates were age , sex , apolipoprotein E genotype , body mass index , vascular risk factors , and antihypertensive medication use.
Covariates were age , sociodemographic factors , health behaviours , and somatic ill-health.
Covariates were baseline age , sex , socioeconomic status ( SES ) , prefrailty status , diabetes mellitus , and comorbidity.
Covariates were sociodemographics , tumor characteristics , and comorbidity index.
Co-variation in the levels of LH and AMH might indicate joint regulatory mechanisms for the latter hormone and gonadotrophins.
Coverage , typically low for maternal vaccines , is key to the vaccine's public health impact.
Cover Image for this issue : doi.
COX-2 expression increases with aging in most tissues , due in part to ROS , chemical reactions , physical shearing , and dietary molecules.
COX-2 expression is positively related with the degree of solar elastosis in photoaging.
Cox analysis confirmed short telomeres in men aged @number@ to @number@ years as an independent prognostic risk factor.
Cox et al. ( ) demonstrated the cardiac effects of NAD + which mitigated chronic heart failure via mitochondrial redox state mechanism.
Cox ( for PCD and mortality ) and stratified Cox ( for falls ) regression models were used.
COX is presented in two isoforms , COX-1 and COX-2 , with the former regarded as constitutive and the latter mainly expressed upon induction.
Cox models were used to assess the associations between lifestyle factors and healthy lifestyle scores and all-cause mortality , adjusting for potential confounders.
Cox proportional hazard analysis was done using GraphPad Prism version @number@
Cox proportional hazard and competing risk regression models were established to estimate the hazard ratio ( HR ) of hip fracture associated with older physicians.
Cox proportional hazard models adjusted for cluster-correlated data were used in cohort analyses.
Cox proportional hazard models and logistic regressions evaluated the predictive ability of both tools.
Cox proportional hazard models estimated hazard ratios and @percent@ CIs for all-cause , coronary heart disease , and cardiovascular disease mortality.
Cox proportional hazard models estimated the relationship between CML and incident disability ( N = @number@ ) .
Cox proportional hazard models failed to show an association between CMV serostatus and all-cause mortality.
Cox proportional hazard models for competing risks , stratified by sex , were defined to determine risk factors in relation to developing dementia.
Cox proportional Hazard Models were adjusted for possible confusion factors.
Cox proportional hazard models were applied , adjusting for potential confounders including age , sex , health status variables and concomitant medication use.
Cox proportional hazard models were applied to select the demographic characteristics that were associated with cumulative mortality.
Cox proportional hazard models were constructed to study the association between WML and risk of MCI / dementia.
Cox proportional hazard models were employed to examine the association between SES trajectories and 8-year all-cause mortality ( 1999-2007 ) .
Cox proportional hazard models were performed to test the predictive capacity of the MNA-SF score and its single components for mortality.
Cox proportional hazard models were used to assess the mortality of elder abuse across levels of psychosocial factors using time-varying covariate analyses.
Cox proportional hazard models were used to assess the relationship between the MD score and all-cause mortality.
Cox proportional hazard models were used to estimate mortality risk associated with changes in levels of perceived uselessness.
Cox proportional hazard models were used to estimate risk of any late GI or bladder diagnosis with or without hospitalization , due to radiation.
Cox proportional hazard models were used to evaluate shopping frequency on death from 1999-2008 with possible covariate adjustment.
Cox proportional hazard regression analysis demonstrated a linear association between the age at implantation and the risk of discontinuing regular CI use.
Cox proportional hazard regression models were used to estimate adjusted hazard ratios ( HRs ) and their @percent@ confidence intervals ( CIs ) .
Cox proportional hazard regression model was used to estimate the effects of IBS on ED risks.
Cox proportional hazard regression was applied to model the risk of cognitive decline.
Cox proportional hazard regression was performed adjusting for patient characteristics , admission status , and psychoactive medication administration.
Cox proportional hazards analysis revealed that sex was not independently associated with either in-hospital mortality or long-term mortality.
Cox proportional-hazards analysis was used to assess association between BMI and mortality.
Cox proportional hazards analysis will be used to calculate adjusted relative hazards of smoking cessation by each variable.
Cox proportional hazards and competing risk models were used to calculate all-cause and breast cancer-specific mortality for up to @number@ years , respectively.
Cox Proportional Hazards ( CPH ) modeling was used to determine hazard ratios across quintiles of micronutrient intake.
Cox proportional hazards models and net reclassification index described associations of BMI with all-cause mortality.
Cox proportional hazards models estimated the hazard ratio ( HR ) of incident dementia.
Cox proportional hazards models examined risks for dementia onset and death.
Cox proportional hazards models examined the influence of LS on time to death.
Cox proportional hazards models were conducted to evaluate the association between subject characteristics and hazard of the first fall.
Cox proportional hazards models were constructed for the outcome of time to death.
Cox proportional hazards models were constructed to compute adjusted hazard ratios ( aHR ) and ascertain risk factors significantly associated with RP.
Cox proportional hazards models were constructed to estimate the hazard ratio of PD associated with blood pressure.
Cox proportional hazards models were fit to assess risk of all-cause , nonsurgical , and surgical hospitalization ; nursing home admission ; and mortality.
Cox proportional hazards models were used.
Cox proportional hazards models were used to assess the mortality risk.
Cox proportional hazards models were used to calculate risk of death according to changes in weight.
Cox proportional hazards models were used to detect the association between AD and the risk of osteoporosis.
Cox proportional hazards models were used to estimate hazard ratios for all-cause and cause-specific mortality.
Cox proportional hazards models were used to estimate the association between life events and dementia , adjusting for lifestyle and cardiovascular risk factors.
Cox proportional hazards models were used to estimate the risk of death according to time-varying estimates of physical activity.
Cox proportional hazards models were used to estimate the risk of mortality independent of potential confounders.
Cox proportional hazards models were used to evaluate the association between voluntary / involuntary job loss and the development of stroke or cardiovascular disease.
Cox proportional hazards models were used to evaluate the role of carbohydrate nutrition in cancer risk.
Cox-proportional hazards models were used to examine associations between HRQOL and OS , adjusting for demographics , comorbid conditions , and clinical characteristics.
Cox proportional hazards models were used to relate these variables to subsequent elective hysterectomy.
Cox proportional hazards model was used to examine mortality and hospitalization over @number@ and @number@ years of follow-up , respectively.
Cox proportional hazards multivariate regression models were used to examine the associations between all-cause mortality and BMI , diet quality , and HRQOL.
Cox proportional hazards regression analysis was performed with age as the underlying time scale and delayed entry.
Cox proportional-hazards regression analysis was used to investigate the association between early determinants at baseline and incident undernutrition.
Cox proportional hazards regression evaluated predictors of first hospitalization over @number@ years.
Cox proportional hazards regression examined baseline , time-dependent , and change in cholesterol levels in relation to incident dementia and AD among all participants.
Cox proportional hazards regression model and Logistic regression were performed to identify risk factors for earlier age of natural menopause and menopausal symptoms , respectively.
Cox proportional hazards regression models and Laplace regression were used to estimate , respectively , hazard ratios of all-cause mortality and differences in survival time.
Cox proportional hazards regression models estimated the risk for incident fractures based on mental disorders and use of psychotropic medications.
Cox proportional hazards regression models were adjusted for cardiovascular disease risk factors.
Cox proportional hazards regression models were used to calculate relative mortality according to continuous levels and quintiles of LTL z scores.
Cox proportional-hazards regression was used to assess the association between eating-with-others and mortality risk.
Cox proportional hazards regression was used to estimate the relationship of quality of care to long-term care placement and survival.
Cox proportional hazards regression was used to evaluate associations between frailty and death.
Cox proportional hazards regression was used to examine the association between the diet score and cancer risks.
Cox proportional hazards regression was used to examine the association between the number of comorbidities and in-hospital mortality in patients with CHF.
Cox proportional hazards survival models evaluated childhood sleep duration as a predictor of mortality separately by sex , controlling for baseline age.
Cox proportional hazards were used to model time to event.
Cox proportional hazard was used to estimate the risk of incident cardiovascular disease during follow-up by baseline snoring and sleepiness status.
Cox-regression analyses estimated the relative risk of register-based long-term sickness absence ( LTSA ) and disability pension with cumulative occupational mechanical exposures throughout working life.
Cox regression analyses were conducted to model predictors delete time until of mortality.
Cox regression analyses were performed to investigate the possible association between measure of body composition and incident heart failure.
Cox regression analyses were performed using a large historical cohort composed of @number@ men and @number@ women.
Cox Regression analysis showed that higher heart rate at rest was the only variable associated with syncope.
Cox regression analysis showed that removable-denture wearers had increased follow-up 4-year mortality risk compared to fixed-denture wearers adjusted for sociodemographic , lifestyle and health-related factors.
Cox regression analysis was used to calculate hazard ratios and @percent@ confidence intervals for disability retirement.
Cox regression analysis was used to examine the association between providing or receiving social support on mortality with different educational levels.
Cox regression and general linear models were used to estimate HR of death and risk ratio ( RR ) of healthy ageing.
Cox regression models adjusted for age , gender and liver fibrosis stage at baseline were applied.
Cox regression models ( full and reduced ) were developed that predict the risk of a global CVD endpoint.
Cox regression models provided hazard ratios ( HRs ) and @percent@ CIs.
Cox regression models were used for the analysis.
Cox regression models were used to determine how gender in interaction with the motor factors was related to mortality.
Cox regression models were used to estimate multivariate steroid sex hormone-associated hazard ratios ( HR ) and @percent@ confidence intervals of dementia.
Cox regression models were used to evaluate predictors of mortality.
Cox regression models were used to examine the effects of dementia and living alone on care needs increases.
Cox regression models were used to test the effect of EE on natural mortality , controlled for age , sex , and body weight.
Cox regression models with time from randomization to the first fall were not significant.
Cox regressions adjusted for multiple potential confounders and normal-pace walking were used to examine the associations.
Cox regression survival analyses demonstrated that both balance / upper strength , and fine motor function were significantly related to mortality.
Cox regression was performed to estimate unadjusted hazard ratios.
Cox regression was used to assess the association between education and dementia related deaths.
Cox regression was used to assess the association between psychological distress and risk of dementia-related mortality.
Cox regression was used to assess whether UFC / Cr measures predicted AD risk.
Cox regression was used to calculate the relative risk of all-cause mortality in each of the four diurnal type groups.
Cox regression was used to compare follow-up mortality risk.
Cox regression was used to estimate hazard ratios ( HRs ) for stroke risk adjusted for potential confounders.
Cox regression was used to estimate the hazard ratios for fracture.
Cox regression was used to estimate the independent effect of bilingualism on dementia conversion.
Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up ( mean @number@ y , range 1-16 ) .
Cox regression was used with BMI / WC quintiles @number@ as the reference.
Cox regression with penalized spline was used to evaluate the association between weight change ( in kg ) and mortality.
Cox's hazard ratios ( HR ) were progressively adjusted for socio-demographic , lifestyle and health characteristics.
Cox's regression , with adjustment for multiple covariates , was used to estimate relative risk of AF.
Cox survival analysis was performed to identify predictors of institutionalisation at one year.
CP-690550 was used to suppress JAK2 signal pathway for measuring aging status of SMCC7721 cells.
Cp concentrations in fetal plasma were < 15% of adult levels.
CPC senescence resulting from NS loss is partially p53 dependent and is rescued by concurrent silencing of p53.
CPD is a successful dialysis option for elderly patients , in both patient and technique survival terms.
C-peptide might be the underlying mechanism of the metabolic syndrome's effect on CEVD.
C-peptide = @number@ U / L and FE ( @number@ ) = @number@ were the tangent points in receiver operating characteristic ( ROC ) analyses.
CPFOase in plasma demonstrated age-dependent increases on a volume of plasma basis , as did total plasma protein levels.
CpG islands ( CGIs ) are commonly used as genomic markers to study the patterns and regulatory consequences of DNA methylation.
CpG loci associated with bladder cancer and aging had neighboring sequences enriched for transcription-factor binding sites related to immune modulation and forkhead family members.
CpG methylation might plausibly play a role in a variety of smoking-related phenomena , as suggested by candidate gene promoter or global methylation studies.
CpG sites corresponding to Lung diseases impose a huge economic and health burden worldwide.
Cp may be involved in the conversion of NO to SNO in plasma under near-physiological concentrations of NO.
CPPs are highly bioactive ligands that induce cell damage and innate immune responses.
CPSSs combining different prescribing quality measures should be considered as an important strategy for optimizing medication prescription for elderly patients.
CPS was significantly , positively related to an EF composite score ( β = @number@ @percent@ CI [ @number@ @number@ ] ) .
CR1 gene analysis , spotting the rs6656401 and rs3818361 polymorphisms , was performed by pyrosequencing.
CR1 length polymorphism was assessed at protein and gene levels using Western blot and high-resolution melting , respectively.
CR1 sites on erythrocytes were enumerated by flow cytometry.
Craggit models estimated ( a ) having any child-related educational debt and ( b ) the amount of debt owed among debtors.
CR , although similar to ED in the target of longevity , mildly reduces the total daily calorie intake while concurrently providing all beneficial nutrients.
Cramer's V was calculated to examine the relationship between each item and the ADL.
Cranberries are thought to prevent UTI.
Cranberry slightly extended life span in flies fed with a high-fat diet.
Cr and Mn concentrations were significantly higher in obese men.
Cr and Ni analyses should be reliable on a group basis , probably due to limited performance inherent to the analysis principle and matrix.
Cranial and dentoalveolar morphologies exhibit a high degree of diversity , but the causes of variation are still relatively unexplored.
Cranial MRI was conducted using a @number@ T unit.
CR appears to prolong life by reducing oxidative damage.
Crash and near-crash involvement were based on video recordings and vehicle sensors.
CRAWS-CV scores were significantly different for wanderers and non-wanderers.
CR can inhibit growth , reduce body size and maintain a low body temperature.
CRC risk derived from red meat intake is influenced by both total intake and its frequency.
CRC screening could be more effective and cost effective if individual factors for each patient are considered.
CRC-set association p-values were used to evaluate enrichment of less frequent variant associations in CR ARE versus non-digestive ARE.
CRC was reduced by @percent@ with aging , indicating sensitization of the mitochondrial permeability transition pore ( mPTP ) to apoptosis.
CR deactivates the target of rapamycin pathway and slows down aging.
C-reactive protein > 10 mg / L and any acute or chronic inflammation were considered as exclusion criteria.
C-reactive protein and interleukin-6 were associated with poststroke cognitive decline among men only.
C-reactive protein and procalcitonin were measured by immunonephelometry and immunoassay , respectively.
C-reactive protein ( CRP ) and erythrocyte sedimentation rate ( ESR ) were measured as markers of non-specific inflammation.
C-reactive protein ( CRP ) failed to discriminate four groups of patients.
C-reactive protein ( CRP ) participates in the systemic response to inflammation.
C-reactive protein is linked to disease state and may be a disease activity marker.
C-reactive protein is measured as primary outcome.
C-reactive protein level was lower in the Enhanced group on day @number@ @number@ and @number@ ( p @number@ ) .
C-reactive protein measurement was used as an inflammatory marker , whereas MBD was evaluated by calcium , phosphorus and intact parathyroid hormone levels.
Created in St. Petersburg Institute of Bioregulation and Gerontology short peptides are known to regulate gene expression and protein synthesis.
Creatine also shows promise for improving bone mineral density and indices of bone biology.
Creatine ( energy metabolism ) did not differ between groups across both ROIs and time points.
Creatine is an inexpensive and safe dietary supplement that has both peripheral and central effects.
Creatine is one of the most popular nutritional ergogenic aids for athletes.
Creatine kinase activity decreased with age and was always lower in the HZ mice.
Creatine kinase ( CK ) , elbow joint angles , arm volume , strength , and soreness were measured over @number@ days.
Creatine kinase levels were negatively correlated with the age at diagnosis.
Creatine may , therefore , be a promising food supplement to promote healthy human aging.
Creatine supplementation is reported to improve muscular strength and performance with training in younger athletes , and therefore could benefit older individuals.
Creating a new culture and developing appropriate clinical , scientific and relational approaches to these patients represent the core of the challenge.
Creating appropriately designed visualizations is valuable towards promoting consumer involvement within the shared decision-making process of care.
Creating partnerships among different delivery sectors is needed for building community infrastructure to enhance the health of older adults.
Creatinine levels ( ≥ @number@ mg / ml ) identified such specimens that were diluted to solve the problem.
Creatinine may therefore be a useful indicator for a predisposition for telomeric attrition.
Creatinine-normalized urinary TBARS and 8-OHdG concentrations were quantified in samples taken from subjects with and without active supplementation.
Creativity has been essential to the development of human civilization.
CREB signaling has been recently involved in several brain pathological conditions including cognitive and neurodegenerative disorders.
CREB signaling is essential for long-lasting changes in synaptic plasticity that mediates the conversion of short-term memory to long-term memory.
Credit scores are the most widely used instruments to assess whether or not a person is a financial risk.
Creep time constant ( η2 / E2 ) tended to increase with crystallinity ( r = 0.422 , p = 0.057 ) .
Cre-induced DNA recombination occurred in all enteric glia and most small bowel myenteric neurons , yet phenotypic effects of Rb1 loss were cell-type specific.
CREM immunoreactivity was found to be widely but unevenly distributed in the adult human brain.
CREM proteins are known to be implicated in a plethora of important cellular processes within the CNS.
Creutzfeldt-Jakob disease ( CJD ) is the most prevalent prion disease in humans.
CRF1 binding in the anterior cingulate was greater in females than in males at both ages.
CRF2 binding in the posterior bed nucleus of the stria terminalis was greater in males irrespective of age.
CRF2 binding in the ventromedial hypothalamus was the same in juveniles , but binding levels increased in males , leading to an adult sex difference.
CRF burden was measured using the Framingham general cardiovascular risk score ( FRS ) .
CRF gene expression in the PVN increased with aging.
CR fitness was lower in those with AD over the study period.
Cr functions as a regulator of insulin action.
CRF was assessed as peak oxygen consumption ( VO2peak ) measured in a maximal exercise test on cycle ergometer.
CRF was assessed by measuring peak oxygen uptake ( [ Formula : see text ] ) .
CRF was assessed by measuring the peak oxygen uptake ( VO2peak ) and VFA by magnetic resonance imaging.
CRF was directly measured as peak oxygen uptake ( VO2peak ) .
CRF was estimated in metabolic equivalents ( METS ) according to Balke treadmill time.
CRF was quantified as maximal metabolic equivalents and classified as low , moderate , and high based on traditional ACLS cut points.
CRGs are a group of genes downstream of cooperating oncogenic mutations previously identified in a colon cancer model that are critical to the cancer phenotype.
( CR ) has been traditionally used as an herbal medicine in Asian countries to treat diverse gynecological disorders.
Crisis religiousness ( praying without other religious activities ) , which is associated with poor health.
CR is the only environmental or lifestyle intervention that repeatedly has been shown to increase maximum life span and to retard aging in laboratory rodents.
Criteria are proposed to define an \ "aging-linked \ " disease , and AD fails all of these criteria.
Criteria for all-cause dementia and for AD dementia were presented.
Criteria for frailty were slow walking speed , exhaustion , weight loss , low physical activity and cognitive decline.
Criteria for sexual interest / arousal disorder require the presence of at least three specific symptoms lasting for at least six months.
Criteria proposed by Fried were used to identify frail subjects.
Criterion and construct validity and interrater agreement were tested for each field strength and image type.
Criterion-referenced ( CR ) fitness standards suggested that @percent@ of the individuals were at risk for loss of independent functioning.
Criterion validity was evaluated against standard clinical diagnoses.
Criterion validity was evaluated by survival analysis and by the correlation between the CP-FI-CGA and specialist-completed FI-CGA.
Criterion validity was verified by means of significant correlations between health composites and MCQ subscales.
Critical age windows have been identified for the onset of putative mechanisms of energy adaptation.
Critical illness can impose immobility in older patients , resulting in loss of strength and functional ability.
Critical intensity was calculated via a linear model and subsequently validated.
CRITICAL ISSUES : Antioxidant treatment is ineffective in patients at risk or with cardiovascular disease.
CRITICAL ISSUES : Both Kv2.1 and BK channels have recently been established as target proteins for regulation by the gasotransmitters carbon monoxide and hydrogen sulfide.
CRITICAL ISSUES : Electron transfer pathways of the oxidative protein folding show conserved Trx-like thiol-disulfide chemistry.
CRITICAL ISSUES : However , the mechanism by which specific protein S-nitrosylation occurs in cell signaling pathways is less well investigated.
CRITICAL ISSUES : In this review , we highlight the roles of mitochondrial sirtuins and their targets in cellular and organismal metabolic homeostasis.
CRITICAL ISSUES : Reported evidence shows that interventions that improve skeletal muscle mitochondrial function also improve insulin sensitivity in humans.
Critically , both age groups showed this pattern , implying that aging does not influence how we learn from mistakes.
Critically , deviations from this trajectory related to cognitive performance.
Critically , due to availability , low visibility or scattered resources , robust network and statistical contextualisation of the resulting data is generally under-represented.
Critically ill cirrhotic patients with acute kidney injury ( AKI ) are associated with high mortality rates.
Critically ill patients or those with severe burns may have higher requirements.
Critically , many genes and cellular pathways directing heart development and function are evolutionarily conserved from Drosophila to humans.
Critically , older adults demonstrated the same resistance to capture by the abrupt onset.
Critically , older adults who maintained negative modulation to difficulty showed higher task accuracy.
Critically short telomeres activate a DNA damage response that leads to the arrest of the cell cycle and resulting in cellular senescence or apoptosis.
Critically , significant associations remained having taken future dementia into account suggesting that they were not explained by incipient dementia.
Critically , the cross-sectional analyses were suggestive of age-related frontal overrecruitment , whereas the longitudinal analyses revealed frontal underrecruitment with advancing age.
Critically , the older participants of this study were not pre-selected for high performance on cognitive tasks , but only screened for normal hearing.
Critically , we found no difference in the activation of the hippocampus between the young and a group of older participants.
Critically , we review the importance of H3.3 turnover as part of epigenetic events that influence senescence and age-related processes.
Critical reviews that focus on differences characterizing IBD between age groups are scarce.
Critical time periods for n-3 fatty acid consumption may differ by sex.
Critical to the construction of summary health measures are values assigned to health states.
Critics argue that early Paleoindian hunters had to be extremely selective to have produced the highly size-biased extinction pattern characteristic of this event.
CRMs alleviated high glucose-induced senescence and EMT via stimulation of AMPK / mTOR signaling.
Cronbach's alpha coefficient for internal consistency was @number@
Cronbach's alpha coefficients , exploratory factor analysis , and the known-groups technique were used for these analyses.
Cronbach's alpha for Iranian version of BBS was @number@ which shows the excellent reliability of the questionnaire ( @number@.62-0.9 for all items ) .
Cronbach's alpha for Tendo muscular power for repeated trials was @number@
Cronbach's alpha for the domains ranged between @number@ and @number@ indicating good homogeneity.
Cronbach's alpha for the entire CSES was @number@ and for the subscales was @number@ and higher.
Cronbach’s alpha of the instrument was calculated.
Cronbach's alpha ranged from @number@ to @number@ and test-retest stability was demonstrated for the majority of items.
Cronbach's alpha reliability coefficients of the instrument ranged from @number@ to @number@ and item-total correlation ranged from @number@ to @number@
Cronbach's alpha was @number@ and Guttman split half coefficient was @number@
Cronbach's alpha was @number@ for factor @number@ and @number@ for factor @number@
Cronbach's alpha was used for analysis of the internal consistency of the TFI.
Cronbach's alpha was used to assess the internal consistency of the short BBS.
Cronbach's alpha was used to test the reliability.
Cronbach's coefficient was used to determine the reliability of the questionnaire.
Cronbach's α for internal consistency was @number@
Cronbach's α for the total Chinese version of the Revised Resilience Scale was @number@ with a range of @number@.85-0.89 for the sub-scales.
Cronbach's α for the total SIB score and each subscale score showed high significance , and the item-total correlation for each subscale was also acceptable.
Cronbach α values ranged from @number@ to @number@
CR or CRMs treatment alleviated age-related EMT in aging kidneys , which was accompanied by activation of AMPK-mTOR signaling.
Crossbreeding into hairless albino mice allowed noninvasive optical measurement of skin oxidative state.
Cross bridge penetration depth peaked in neonates then remained unchanged at subsequent ages.
Cross bridges were first observed at @number@ days fetal gestation.
Cross-cohort multivariate analyses showed that the higher odds of control in 2004-2005 cohorts were accentuated by adding diabetes to the model.
Cross-cohort multivariate analyses showed that the higher odds of hypertension in the 2004-2005 cohort was attenuated by adding diabetes and obesity to the model.
Cross-country comparisons can allow national and global insights and provide evidence for policy and decision-making.
Cross-cultural studies of advertising representations of older people are relatively scarce.
Crossed and uncrossed disparity thresholds were measured using white light under conditions of best optical correction.
Cross-lagged path analysis within a structural equation modelling framework was used to examine the bi-directional relationship between the two measures.
Cross-lagged paths from youth AUD to young adult CUD and youth CUD to young adult AUD were both significant.
Cross-legged sitting was the most preferred ( @percent@ ) floor-sitting position.
Cross-linked carboxymethylcellulose is one of these and represents a new alternative for the correction of wrinkles and facial defects.
Cross-linking , autofluorescence and UV-Vis spectrophotometry assays were performed and indicated a dose-dependent linear increase in cross-linking and autofluorescence of gelatine by ribose and MG.
Crosslinking of DNA was evident by agarose gel electrophoresis of S1 nuclease digested DNA , hydroxyapatite chromatography and comet assay.
Cross-national comparative research identified similar risk factors , suggesting robust associations.
Cross-national comparative research identified similar risk factors , suggesting robust associations.
Crossover and near-transition hospice patients had higher costs to Medicare compared to other groups ( p < @number@ ) .
Crossovers are formed as an outcome of recombination.
Cross-polarized imaging at different wavelengths emphasizes different features of human skin.
Cross-polarized @number@ nm images were acquired noninvasively from facial skin of the study subjects.
Cross-polarized @number@ nm wide-field images clearly delineated collagen networks.
Cross-polarized @number@ nm wide-field images were acquired from peri-orbital areas before and two weeks after the onset of the treatment regimen.
Cross-polarized photography was best for visualizing hyperpigmentation , but also heightened visualization of hypopigmentation and subsurface features such as vascularity.
Cross-race fixed effects meta-analyses were Bonferroni-corrected for the number of variants or genes tested.
Cross-reactivity and interferences were minimal and no high-dose hook was observed.
CROSSROADS utilized a lifestyle intervention approach consisting of exercise , dietary , and behavioral components.
Cross-sectional analyses.
Cross-sectional analyses demonstrated that various factors were important to institutionalization at different ages.
Cross-sectional analyses evaluated the association of self-reported function with objective physiological impairment measures.
Crosssectional analyses indicate that the association between depressive symptoms and performance is not linked to specific cognitive domains.
Cross-sectional analyses of current neurocognitive , functional , and physical status were conducted.
Cross-sectional analyses revealed age-related differences in all WM indices across the regions.
Cross-sectional analyses were conducted on patient characteristics , diagnosis , procedures received , and triage status.
Cross-sectional analyses were performed in @number@ U.S. population-based samples.
Cross-sectional analysis.
Cross-sectional and longitudinal analyses were conducted.
Cross-sectional and longitudinal associations of loge-CRP and lung function were examined using multivariable linear mixed models.
Cross-sectional and longitudinal relationships between 25 ( OH ) D and anxiety were examined using logistic regression analysis , taking into account relevant confounding variables.
Cross-sectional and longitudinal relationships between individual BPSD , cognition , and dependence over @number@ years were characterized by using multivariate latent growth curve modeling.
Cross-sectional and prospective research shows that physical activity is predictive of better cognitive performance for those at greater genetic risk for AD.
Cross-sectional area ( CSA ) measurements were taken by tracing inside the fascial borders on magnetic resonance images.
Cross-sectional area ( CSA ) , muscle strength ( MVC ) , and biomechanical properties of m. quadriceps and patellar tendon were determined.
Cross-sectional areas of individual adipocytes were calculated digitally and averaged from histologic sections of the adipose tissue samples.
Cross-sectional areas of types @number@ and @number@ and volume density of type @number@ muscle fibers decreased significantly with age.
Cross-sectional associations between MeDi and baseline MRI measures in @number@ participants were not significant.
Cross-sectional / case control and longitudinal studies reporting data on the association between frailty and anti-oxidants-OS biomarkers were considered for inclusion.
Cross-sectional clinical data , physical performance , and muscle mass measurements were collected.
Cross-sectional comparison of cortical thickness in EOD vs. LOD.
Cross-sectional comparisons were performed using patient samples of @number@ and @number@
Cross-sectional correlations between age acceleration and the fitness variables were calculated.
Cross-sectional data from the @number@ phase of the Longitudinal study of Aging in Women ( LAW study ) was analyzed.
Cross-sectional data from Wave @number@ ( 2008-2009 ) of the English Longitudinal Study of Aging ( ELSA ) were analyzed.
Cross-sectional data indicate that migratory behavior changes in the sixth decade of life.
Cross-sectional data of @number@ men and @number@ women was collected from old Korean adults living in Seongnam , Korea.
Cross-sectional data were analyzed from a population-based sample of @number@ men and women aged @number@ or older and living in one typical city in Korea.
Cross-sectional differentiation between dementia-free and dementia patients yielded moderate to good results for MMSE and SMMSE scores.
Cross-sectional estimates of age-related changes in brain structure and function were compared with 6-y longitudinal estimates.
Cross-sectional evidence from observational studies suggests that greater arterial stiffness is associated with worse cognitive performance.
Cross-sectional evidence suggests that elevated CRP may even be protective in this age group.
Cross-sectional inspection suggests that both calf circumference and MAMC decline nonlinearly with age and the rate of decline varies by gender.
Cross-sectional inverse associations between lower PedsQL and higher BMI categories were similar to those for elementary school children.
Cross-sectional logistic regression models were constructed to assess the associations of these factors with prevalent pain , adjusted for other known pain correlates.
Cross-sectionally , Freesurfer's effect size was significantly different in the posterior division of the temporal fusiform cortex.
Cross-sectionally , reasoning ability was most strongly related to FC between RLPFC and IPL in adolescents and adults , but to frontoparietal SC in children.
Cross-sectional magnetic resonance imaging ( MRI ) studies suggest thinning of the cerebral cortex , volumetric reductions of most subcortical structures , and ventricular expansion.
Cross-sectional outcomes were assessed using generalized linear models.
Cross-sectional research suggests that IIV increases with normal and neuropathological ageing and it may serve as a marker of neurobiological integrity.
Cross-sectional specimens and tissue sections were compared between the two groups to identify the differences.
Cross-sectional studies describe shorter telomeres in COPD compared with matched controls.
Cross-sectional studies have found that obesity is associated with low intellectual ability and neuroimaging abnormalities in adolescence and adulthood.
Cross-sectional studies have shown age-related increases in blood docosahexaenoic and eicosapentaenoic acid and decreases in arachidonic acid.
Cross-sectional studies showed no difference in sexual dysfunction between older and younger women.
Cross-sectional studies showed that frail individuals have lower cognitive performance compared with nonfrail persons.
Cross-sectional studies show that older people with better cognition tend to walk faster.
Cross-sectional studies suggest a water-loss dehydration prevalence of 20-30% in this population.
Cross-sectional studies support this hypothesis , showing greater ABPV among older compared to younger adults.
Cross-sectional vascular area calculated using this automated oscillometric measurement correlated with ultrasound measurement and showed good reproducibility.
Cross-site errors were not significantly larger than within-site errors.
Cross-species comparison of phosphorylation events is a powerful mean to functionally prioritize and identify physiologically meaningful phosphorylation sites.
Cross-tabulations were run to show the rise in chronic disease and disability with age.
Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed.
Cross validation of the results obtained from blood samples demonstrated the robustness and reproducibility of the assay.
Cross-validation showed that adding information on comorbidities to the quantile regression improved the accuracy of predicted individual expenditures.
Cross-validation using data from a 2 ( nd ) group of @number@ older adults showed similar results.
CrossWork searches batches of tandem mass-spectrometric data , and identifies cross-linked and non-cross-linked peptides using a standard PC.
Crotonaldehyde is a four carbon unsaturated bifunctional aldehyde produced both exogenously and endogenously.
Crowding also varied across settings and locations by time of day.
Crowding further exacerbated deficits in contrast sensitivity to three times the normal crowding-induced contrast energy threshold elevation.
Crowding , location , and sound were measured three times per observation ; ambiance was measured once.
Crowding thresholds were also estimated with spatial uncertainty ( jitter ) .
Crowding was also measured in young and age-matched controls at the same retinal locations , using a fixation-contingent display paradigm to allow unlimited stimulus duration.
Crowding was not affected by spatial jitter of the stimuli.
Crowdsourced classification of research data may offer a valid solution to problems of throughput requiring human input.
Crown completion ages for southern Africans were calculated in two ways.
CRP and depressive symptoms were measured at baseline and follow-up.
CRPC cells showed an increased expression of ACSL3 and an expression pattern of AKR1C3 and UGT2B similar to ACSL3-overexpressing cells.
CRP level may be a useful indicator for detecting the lower physical performance in elderly.
CRP levels were assessed by the nephelometric method utilizing latex particles coated with CRP monoclonal antibodies.
CRP levels were significantly associated with MAR , dual-energy x-ray absorptiometry-measured body fat , and hypertension.
CRP may be useful to identify individuals who are at risk of developing delirium.
CRP revealed a negative correlation with DHEA ( r = @number@ P < 0.05 ) , although not with DHEA-S.
CRP values decreased in TG only.
CR reduced the mean volumes of every hippocampal region investigated ( on average @percent@ ) in both 12-month-old , and 24-month-old mice.
Cr + RT had a greater effect than RT alone on the 30-s chair stand test ( P = @number@ ) .
CRRTs in males aged 11-20 years were longer than those in females in some directions on all three body sites.
CR severely reduced the level of energy storage molecules including glycogen and lipid droplets , whereas RM did not.
CR-specific ARE were also enriched for stronger CRC-variant associations compared to ARE combined across non-digestive tissues ( p-value = @number@ × 10-4 ) .
CRTCs have been shown to modulate organismal aging in Caenorhabditis elegans and to impact on age-related diseases in humans.
CRT eligibility was determined by QRS ≥120 ms , left ventricular ejection fraction ≤35% , and New York Heart Association class III / IV.
Crucially , behavioral measures of mathematics , IQ , working memory , and reading did not predict children's gains in numerical abilities.
Crucially , the positive effect of the ToM intervention generalized to metamemory knowledge.
Crucially , we also found that this phenomenon is correlated with structural hippocampus integrity.
Crucial questions concerning the factors regulating repair and the causes of individual variation are as yet unanswered.
Crude and adjusted binary logistic regressions were performed to identify individual associations between physical and mental conditions.
Crude and adjusted logistic regression was used to examine associations between dementia and clinical , social , and nutritional factors.
Crude and adjusted multilevel models were analyzed to study the independent associations of study year and socio-demographic , health , and municipal characteristics with loneliness.
Crude and adjusted odds ratios ( OR [ @percent@ confidence interval ] ) were calculated.
Crude and adjusted percentage increases were also calculated for the whole period and for the 2001-2006 and 2006-2012 sub-periods.
Crude and adjusted prevalence ratios were estimated using Poisson regression.
Crude and multiple logistic regression-derived adjusted odds ratios were used as indicators of the associations between BC and the variables under study.
Crude and standardized mortality rates by ALS were calculated at the nationwide level and by geographic zone.
Crude and standardized prevalences ( using PAQUID age-sex structure ) and @percent@ confidence intervals were calculated , and logistic regression was used to explore confounding.
Crude effect estimates were extracted from the included articles and a pooled estimate was obtained using a random effects model.
Crude extracts and pure compounds from Anemarrhena asphodeloides exhibited significant pharmacological effects on the nervous system and the blood system.
Crude incidence , age specific incidence and age-adjusted incidence rates were calculated.
Crude incidence and age-standardized rates ( ASRs ) , using the Segi's world standard population , were calculated for CRC and CRC subsites.
Crude mean MPOD increased with ascending stage of ARM.
Crude mortality at last contact of follow-up was @number@ %.
Crude odds ratios ( ORs ) and their corresponding @percent@ confidence intervals ( @percent@ CI ) were calculated.
Crude prevalences of asthma were , however , consistently higher among urban than rural dwellers.
CR was indexed by years of education , reading , and vocabulary measures.
CR was operationalized as years of formal education.
CR was provided in eight , 2-h weekly didactic sessions and online at-home exercises.
Cryab expression was also upregulated in reactive astrocytes and microglia in a neurotoxin-induced mouse PD model.
Cryptocapsin showed the highest bioactivity , while cryptocapsin-5 , 6-epoxide and zeaxanthin exhibited similar activity on anti-aggregation assays.
Cryptococcus neoformans , similar to other eukaryotes , undergoes replicative aging.
Cryptorchidism represents a risk factor for infertility and germ cell testicular neoplasia.
Cryptosporidium parvum positive samples were subtyped using the @number@ kDa glycoprotein ( gp60 ) gene.
Cryptosporidium was most commonly detected in spring ( @percent@ ) , followed by summer ( @percent@ ) , then winter ( @percent@ ) .
Crystallin modifications and cleavage were quite dramatic in transgenic mouse lenses with mature cataract.
CSA and CT were highly correlated with conventional BMD , whereas ED , SM , and PD showed lower correlations.
CSB alone remodels nucleosomes ∼10-fold slower than the ACF remodeling complex.
CSB , a transcription-coupled repair ( TCR ) protein , facilitates repair of some of the same oxidative lesions.
C , SB-Vit.
CSCs and normal stem cells share some properties , but CSCs differ from normal stem cells in their tumorigenic ability.
CSCs may derive from a few tumor-initiating cells , which are either transformed normal stem cells or reprogrammed differentiated cells after acquiring initial cancer-causing mutations.
CSDD score at baseline and development of severe cognitive impairment at follow-up were independent risk factors for incident depression.
CSE also increased IL-1b expression and secretion after C3a generation and was reduced by a C3aR antagonist.
CSF autotaxin may be a useful dysmetabolism biomarker for examining AD outcomes and risk.
CSF Aβ ( @number@ ) levels were tested for associations with Aβ degradation and clearance genes and APOE ε4.
CSF biomarker changes did not correlate with changes in Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale motor scores or dopamine imaging.
CSF catecholamines and its metabolites were analyzed by HPLC with electrochemical detection.
CSF concentrations of α-synuclein , blood pigments and the erythrocyte count were determined.
CSF cortisol concentrations were increased in the subjects with AD dementia or MCI-AD compared with subjects with MCI-O or normal cognition.
CSF DOPAC is low in PD-even in patients with recent onset of Parkinsonism.
CSF from MSA patients ( MSA-CSF ) promoted fαS formation more strongly than PD- , hSCA- , or headache-CSF.
CSF levels of ADA also decreased.
CSF levels of Aβ1-42 , T-tau , P-tau181 , and ratios of T-tau / Aβ1-42 and P-tau181 / Aβ1-42 were analyzed.
CSF NfL , but not other CSF measures , correlated with CDRsb and neuropsychological measures in FTD , but not in other diagnostic groups.
CSF NFL concentrations in the untreated neuroasymptomatics and treated groups were equivalent to controls @number@ and @number@ years older , respectively.
CSF oligomers ranged between @number@ and @number@ pg / ml.
CSF orexin-A but not HA / t-MHA levels were higher in MCI and AD than OND and controls.
CS formation was confirmed by red shift as well as enhancement in the luminescence peak compared to bare Q-dots.
CSF samples were collected preoperatively.
CSF / serum albumin ratio correlated with CSF neurofilament light in LAD , MIX , VaD , and other groups but not with AD biomarkers.
CSF was analysed for free and encapsulated cytarabine , and plasma was analysed for free cytarabine.
CSF was collected from consenting patients who required a spinal tap for the administration of anesthetic.
CSF α-syn levels at @number@ months were lower in patients with PD treated with dopamine replacement therapy , especially dopamine agonists.
CS inhibits the expression of lipogenic genes in colorectal cancer cells.
CS is a part of the aging program and involves multiple signaling cascades and transduction mechanisms.
CSIs facilitate pooling of sensitivities to reduce the variability of individual test locations.
CSM treatment increased MAO-B activity , ROS levels and IL-8 release in AECs.
CSOL had no effect on the transcriptional levels ( mRNA ) of these enzymes.
CSOL may thus be explored as a novel agent for slowing the human aging process.
CSOL significantly prolonged the lifespan of the fruit flies under physiological conditions.
CSP in the older age group was significantly higher than that in the younger age group ( p < @number@ ) .
CSP was shorter in RLS only when compared to apneic patients , whereas it was similar between OSAS and controls.
CSRT induced increases in GH at rest and in response to the WAnT in YT and MAT ( P < 0.05 ) .
CSRT-induced increases were observed for IGF-1 and IGFBP-3 at rest in MAT only ( P < 0.05 ) .
C statistics from the models for survival and IDC were @number@ and @number@ in the GCS model.
CST IV-A was characterized by Streptococcus and Prevotella , whereas CST IV-B was characterized by Atopobium.
CSTs dominated by L. crispatus and L. iners were more prevalent in premenopausal women.
C ) Stunted growth with chronic malnutrition and potential for catch up growth.
CS was measured using a Pelli-Robson chart.
CTAB liposomes induced complete leakage of lactate dehydrogenase ( LDH ) at all concentrations tested , whereas SME liposomes released LDH in a concentration-dependent manner.
CTAB liposomes proved to more effectively activate neutrophils compared with SME liposomes , as indicated by increased superoxide anion and elastase levels.
CT and foveal thickness were also significantly but modestly correlated ( r = @number@ p = @number@ ) .
CT and MRI are all beneficial to the diagnosis of CFBA.
CT and MRI Techniques for Imaging Around Orthopedic Hardware.
CT average values in STGD and in the control group were first compared by means of Student's T test.
CTA was performed routinely at @number@ months after operation to detect the endoleak of contrast agent.
CT displayed large variations among different points in and outside of the vascular arcade.
CT-enteroclysis and VCE allowed a diagnosis in @number@ of @number@ endoscopy-negative patients ( @percent@ ) .
CT findings typical for IPA prompt targeted treatment , and mycological confirmation.
CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups.
C ) their μTBS during @number@ months of storage.
CT induced the most robust improvements in mitochondria-related outcomes and physical characteristics despite lower training volumes for the ET and RT components.
CT may be influenced by cultural and linguistic factors , but research examining CT programs has mostly been conducted on Western populations.
C. trachomatis positives were @percent@ asymptomatic , none had pelvic inflammatory disease or infertility histories.
C. trachomatis was detected in @number@ cases ( @number@ % ) of adult conjunctivitis.
CT / RT consisted of pelvic irradiation plus cisplatin based chemotherapy.
CT scans were obtained for all patients @number@ year after surgery to evaluate for fusion.
CT was independent of lifestyle-associated parameters.
CT was measured at a total of @number@ points in each patient to construct a map of CT distribution.
CT was measured from the outer limit of the retinal pigment epithelium to the inner surface of the sclera.
CT was measured manually using the caliper tool of the optical coherence tomography device.
Cubans are living longer and the country has a very low birthrate.
Cuba's National Intervention Strategy for Alzheimer Disease and Dementia Syndromes is designed to address this challenge.
Cubic splines suggested a non-linear relation between Gal-3 and HF.
Cu could contribute to Aβ accumulation by altering its clearance and / or its production.
Cucurbitacin I isolated from bitter gourd / melon also exhibited a moderate anti-PAK1 activity.
Cued changes resulted in a less decreased performance than uncued changes in both age groups.
Cueing or switch predictability did not affect age differences.
Cues in both tasks corresponded with the index and middle fingers of either the left or right hand.
Cu ( II ) caused additional heterochromatinization of heterochromatin , and Cd ( II ) caused deheterochromatinization of facultative and constitutive heterochromatin.
Cultivated primary Tangier fibroblasts were characterized by premature aging in culture and were associated with less obvious biochemical differences.
Cultural adaptation is important to assess ; however , most acculturation measures are unidimensional with little psychometric data for older immigrants.
Cultural attitudes about medical decision-making and filial expectations may lead some surrogates to experience stress and family conflict.
Cultural diversity affects older adults ' acceptance of fall prevention interventions.
Cultural factors included measures of cultural identity and traditional healing practices.
Cultural factors such as coresidence with children and intergenerational transfer were associated with reduced RRR of high frequency of self-perceived uselessness.
Culturally appealing arthritis interventions ultimately may increase the use of existing arthritis interventions.
Culturally appropriate interventions that lower the prevalence or the functional consequences of obesity and diabetes mellitus in blacks could substantially decrease this racial health disparity.
Culturally sensitive approaches were essential to developing trusting relationships.
Culturally sensitive health services are needed to meet the needs of older Indigenous people.
Culturally sensitive interventions designed to facilitate effective utilization of future plans within this caregiver population are needed.
Culturally tailored programs are required to address the risk in the Chinese population.
Cultural relevancy of health interventions is important in the context of Chinese communities.
Cultural standards of masculinity have particular impacts upon men with the condition , thus generating distinctive challenges.
Cultured CD8 + blood T lymphocytes underwent replicative senescence that was associated with loss of CD28 and Δ133p53 protein.
Cultured cells under normal growth conditions possess a number of ANS-binding structures.
Cultured fibroblasts and keratinocytes provide a biologically relevant model system to investigate the complex pathways of sex steroid intracrinology in human skin.
Cultured pericytes isolated from distinct tissues can differentiate into multiple cell types in vitro or following transplantation in vivo.
Cultured primary cells were fractionated into secreted , cytoplasmic and nuclear protein fractions and processed for subsequent LC-MS / MS analysis.
Culture explained @percent@ of the variance in the importance ratings of QOL.
Cultures of hOBs were obtained from @number@ elderly ( 73-85 years ) and @number@ young ( 21-27 years ) healthy individuals.
Culture supernatant , intact cells , and intracellular cell-free extracts of B. animalis @number@ were involved in this study.
Cumulative dose of haloperidol among intubated patients did not change their already high likelihood of next-day delirium.
Cumulative evidence indicates that the heat shock chaperone Hsp70 possesses robust neuroprotection against various intracellular amyloids in Drosophila and mouse models.
Cumulative evidence suggests that PEW , muscle wasting and cachexia are common and strongly associated with mortality in CKD , which is reviewed here.
Cumulative graft life of two transplants was similar regardless of the order of deceased-donor and living-donor transplantation.
Cumulative incidence increased markedly after the age of @number@ years in men and after @number@ years in women.
Cumulative incidence of neurologic health conditions was reported.
Cumulative incidence of VI and blindness , and factors associated with these outcomes , were estimated.
Cumulative long-term exposure to solar ultraviolet radiation promotes premature skin aging characterized by wrinkle formation and reduced skin elasticity.
Cumulatively , these changes play important roles in the pathogenesis of alterations in inflammation and immunity associated with aging.
Cumulatively , these new observations provide a basis to integrate epigenetic inheritance.
Cumulatively , this manuscript addresses how multimodal data in ADHD can be interpreted by latent dimensions.
Cumulative oxidative damage tends to be pervasive among cellular macromolecules , impacting proteins , lipids , RNA and DNA of cells.
Cumulative psychological burden over time was significant for participants with hypertension , diabetes , heart diseases , or arthritis.
Cumulative standard daily doses ( SDD ) of nonselective NSAIDs were determined from ≥10 years of computerized pharmacy dispensing data.
Cumulative stress index was increased from @number@ ± @number@ mm Hg·min pretraining to @number@ ± @number@ mm Hg·min posttraining ( P < @number@ ) .
Cumulative toxic effects from exposure to antiretroviral drugs for decades can cause clinically-relevant metabolic disturbances and end-organ damage.
Cumuli appeared re-compacted after culture , irrespective of the age of the patients.
Cups were placed near the dental unit.
Curative surgery remains the treatment offering the best survival rates to the patient whatever his age.
CURB65 scores on admission significantly predicted risk of death during the hospital admission and at @number@ days.
CURB65 scores were not predictive of 1-year mortality.
Curcumin also induced mild ER stress similar to bone morphogenetic protein @number@ ( BMP2 ) function in osteoblast cells.
Curcumin also induced nuclear factor @number@ accumulation in the nuclei.
Curcumin also reduced body weight gain and body fat without affecting fat distribution.
Curcumin caused inhibition of rDNA transcription , which could be due to SIRT7 downregulation , site-specific methylation of RNA18S5 gene promoter or both.
Curcumin-induced DNA methyltransferase @number@ ( DNMT2 ) upregulation was also shown.
Curcumin is a dietary constituent with tumor-suppressing potential , inhibiting various pathways involved in carcinogenesis.
Curcumin , resvertrol , piperine , and other polyphenols have been explored as novel therapeutic and preventive agents for AD.
Curcumin stability during the release study was maintained.
Curiously in the latter , the association was independent of its left / right direction.
Curiously , no study until now has examined the associations and dissociations between these dimensions in elderly people ( with or without dementia ) .
Curiously , their secretion shows parallel and severe age-related reductions.
Curiously , the reasons for the efficiency of the combination of β2M with SA remain not clear-cut.
Current AD biomarkers fall into two categories : biomarkers of amyloid-β plaques and of tau-related neurodegeneration.
Current age did not have a significant effect on BNPS prevalence.
Current ALS clinical trials are also deliberated.
Current and future avenues to improve the humoral immune response in the elderly are discussed.
Current and future policies for improving HRQoL in old age should be extended to cover the most vulnerable groups.
Current and potential strategies for the medical management of cSDH are discussed.
Current and potential uses of adaptogens are mainly related to stress-induced fatigue and cognitive function , mental illness , and behavioral disorders.
Current antiaging therapy consists of lasers , intense pulsed light as well as fillers , neurotoxins , radiofrequency , microdermabrasion and chemical peeling.
Current antihypertensive treatments have limited effects on arterial stiffness , so the development of new treatments addressing neurohormonal alterations central to vascular ageing is important.
Current approaches for evaluating anticancer therapy-induced injury have limitations , particularly lack of sensitivity for early detection of subclinical cardiac and cardiovascular dysfunction.
Current approaches to evaluation of efficacy and safety of potential life span extending drugs ( geroprotectors ) are reviewed in the paper.
Current approaches to falls prevention mostly rely on secondary and tertiary prevention and target individuals at high risk of falls.
Current approaches to replace or restore significant quantities of lost bone come with substantial limitations and inherent disadvantages that may in themselves cause further disability.
Current article focuses on the role of JAM-A protein in pathogenesis associated to ageing : atherosclerosis , apoplexy , thrombosis , hypertension , ophthalmological pathology.
Current available data do not suggest significant age-associated differences in the clinical profile of ICIs.
Current available data indicate that Japan is the country with the highest number of currently alive SCs.
Current avenues of AD research focus on pre-symptomatic biomarkers that will assist with early diagnosis of AD.
Current biochemical methods are not very efficient in identifying and differentiating large-scale prenylations in vivo or in vitro.
Current body mass index ( BMI ) strata likely misrepresent the accuracy of true adiposity in older adults.
Current by the osteoporosis and bone metabolism diseases diagnosis and treatment efficacy.
Current cardiovascular risk scores do not include obesity or fat distribution as independent factors , and may underestimate risk in obese individuals.
Current CD4 count associated with higher AMH in both HIV-infected and HIV-uninfected women.
Current cell therapies , despite all of the progress in this field , still faces major ethical , technical and regulatory hurdles.
Current challenge in modulating mitophagy for cellular protection involves identification of physiological ways to activate the pathway.
Current challenges facing theory and practice in ageing sciences need new methods of experimental data investigation.
Current clinical diagnostic methods are invasive and uncomfortable for patients.
Current clinical guidelines and recommendations regarding the diagnosis and monitoring of LOH are also summarised.
Current community-level factors such as air quality and labor force participation rate were significantly associated with levels of health deficits in old age as well.
Current critical thinking has established the primacy of mitochondrial function in maintaining good health throughout plant and animal phyla.
Current data show an increase in FSH and decreases in AMH , inhibin B and estradiol over MT.
Current data suggest that the biological differences between sexes allow men to have better marathon performance across most of the human life span.
Current diagnosis time is about 12-months due to lack of objective methods.
Current dietary databases lack the appropriate information to ascertain valid dietary intakes of these individual nutrients.
Current diet , weight , smoking , physical activity , medication use , and other risk factors for hip fractures were reported on biennial questionnaires.
Current divergent thinking tests allow researchers to study children's divergent thinking from the age of @number@ years on.
Current dogma suggests that aerobic exercise training has minimal effects on skeletal muscle size.
Current drug treatments have only modest effects on the symptomatic course of the disease.
Current dry AMD treatments cannot cure or reverse vision loss.
Current estimates on the burden of cancer are needed for cancer control planning.
Current evidence indicates that sclerostin likely functions as a local / paracrine regulator of bone metabolism rather than as an endocrine hormone.
Current evidence reveals high mortality rates within @number@ months to @number@ year among frail elderly patients who suffer hip fracture.
Current evidence suggests that functional status is an important outcome of pharmacologic treatments in older people.
Current evidence suggests that inflammatory process represents next component , which significantly contribute to degeneration progression.
Current evidence suggests that physical activity ( PA ) and sedentary behavior are important for cognition.
Current evidence suggests that preoperative statin therapy , tight glycemic control or urine alkalinization with bicarbonate do not protect the kidneys from harm.
Current evidence supports aerobic exercise , mental activity , and cardiovascular risk factor control in patients with MCI.
Current evidence supports that exergaming improves cognitive function and dual-task function , which potentially leads to fall prevention.
Current evidence supports the hypothesis that the UFOV recruits both early perceptual and later cognitive processing involved in attentional control.
Current evidence supports the role for both atherosclerosis and arteriosclerosis as a common pathophysiological ground for the heart-brain connection in ageing.
Current exercise guidelines are focused predominantly on aerobic programs despite evidence that age-associated declines are mediated by peripheral tissue changes.
Current findings are likely to be informative in terms of understanding emotion dysregulation in older adults at risk of experiencing clinical symptoms of depression.
Current findings suggest that both IGF-1R and FOXO3A polymorphisms could be associated with longevity.
Current findings support a physiological role for iAβ in neuronal function over the entire lifespan.
Current gaps in nursing specialty education include school health and mental health.
Current guidelines suggest a BMI @number@ kg / m ( @number@ ) or lower as major trigger for nutritional support.
Current guidelines support cholecystectomy after a first acute biliary complication.
Current health and social services are not addressing the complex needs of this group or their family caregivers.
Current health psychological theories and research mainly cover improvement of health , recovery from illness or maintenance of health.
Current health recommendations need to be adjusted accordingly.
Current housing shortage in Italy is forcing a growing number of individuals to use as living environment spaces that were originally devoted to other purposes.
Current hypotheses suggest that aberrant wound healing has a critical role in the pathogenesis of idiopathic pulmonary fibrosis ( IPF ) .
Current investigations show a steep increase of dementia with age.
Current in vivo experimental models yield important information , but they too have a significant amount of variation.
Current knowledge of inhibitory control development in the early school years is limited due to a lack of normative data from age-appropriate , sensitive measures.
Current knowledge on paediatric mucormycosis is based on case reports and small series reported over several decades.
Current knowledge supports both hypotheses with conflicting data , depending on which stage of autophagy is examined.
Current literature assessing the impact of chronic disease on leg power has not yet been comprehensively characterized.
Current literature has illustrated the efficacy of autologous , stem cell therapies as novel strategies for treating these disorders.
Current literature , including a systematic review , is analyzed and rated for quality.
Current literature supports the use of mineral-to-matrix ratio , carbonate-to-phosphate ratio , and mineral crystallinity as measures of bone quality.
Currently about @number@ children have had a definitive diagnosis worldwide with the exclusion of Nigeria.
Currently , AD is defined by the regional presence of neuritic plaques and neurofibrillary tangles in the brain.
Currently , a multidisciplinary approach offers the most complete improvement in the vocal quality of life in this patient population.
Currently available combinations of estrogens with selective estrogen receptor modulators moderately increase BMD without causing the extra-skeletal adverse effects of each compound alone.
Currently available comparative studies of face-lifting outcomes consider surgeon opinion and postoperative complications rates.
Currently available evidence does not support routine clinical use of prophylactic antibacterials in stable COPD.
Currently available evidence seems to best fit a model , wherein rapamycin extends lifespan by suppressing cancers.
Currently available topical products for hyperpigmentation are limited by their potential for irritation , lack of demonstrated efficacy or regulatory concerns.
Currently , CBCT examinations are being performed and contain important information for the quantitative study of dental tissue.
Currently , clinicians have only tPA available for stroke treatment and hypothermia for cerebral palsy.
Currently , common logging operations do not create suitable openings for the regeneration of these species , whereas deforestation degrades landscapes.
Currently , data on the immunogenicity of this vaccine in older adults are nonexistent.
Currently , drugs targeting RAAS are not given for the purpose of preventing diabetes in humans.
Currently , DUBs have a central role in our understanding of various cancers , and some have potential in the development of effective therapeutic strategies.
Currently , effective monomeric compounds or active parts have been screened for pharmacological activity from Epimedium in vivo and in vitro.
Currently elevated depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale ( CES-D ; score ≥18 ) .
Currently , filler implementation is among the most common minimally invasive procedures for rejuvenation and body sculpturing.
Currently , half of the world population resides in cities.
Currently heat stroke is a more preventable than treatable condition , and novel therapeutics are required to improve patient outcome.
Currently , hospital expenditures account for approximately one-third of total national health care spending.
Currently , however , it is not possible to simultaneously map spatio-temporal propagation of activation and resulting tissue strain.
Currently , in many countries most workers are covered by a national social security benefits program that applies equally in all parts of the country.
Currently , it appears that performance decrements are inevitable with age.
Currently , it is the highest ranked pathogen transmitted by blood transfusion.
Currently , layer resolution large-scale proteomic studies describing \ "normal \ " age-related alterations at OFC are not available.
Currently , lifestyle change is the first line of treatment for MetS.
Currently , little is known about how these relationships vary across the lifespan.
Currently , many immigrants are disqualified from Canada's public pension scheme because of residency requirements.
Currently many older persons have been vaccinated against selected pathogens during childhood but lack regular booster immunizations.
Currently , many studies exclude older adults who deeply affect the clinical care of this population.
Currently , most epidemiologic research does not sufficiently address this issue in relation to disease etiology.
Currently , most prostate cancers are diagnosed in elderly males.
Currently , multivariate pattern analysis ( MVPA ) enables the exploration of subtle and distributed changes of data obtained from structural MRI images.
Currently , new knowledge about the role of the SNS in the development and pathophysiology of osteoporosis is being generated.
Currently , NEXus offers over @number@ courses , organized into @number@ clusters such as gerontology and chronic illness.
Currently no antidote is known that resurrects the phosphyl-AChE complex once aging has occurred.
Currently , no definitive treatment algorithm has been established.
Currently , no efficacy data is available from clinical trials of β-secretase inhibitors.
Currently , no framework for the concept of healthy menopause exists , despite its recognized importance.
Currently , no medications have proven effective for MCI ; treatments and interventions should be aimed at reducing cardiovascular risk factors and prevention of stroke.
Currently , no molecular signatures are available to evaluate platelet aggregation.
Currently , non-communicable diseases are more prevalent , and most of them are related to changes in our daily habits and degenerative processes.
Currently none was using HRT despite experiencing menopausal symptoms.
Currently no therapy is approved for the treatment or prevention of cachexia.
Currently , @number@ states and the District of Columbia have adopted FPA for NPs , with @number@ more states planning legislation in @number@
Currently , nutritional supplementation and physical therapy are the strategies advocated for the management of sarcopenia once it is diagnosed.
Currently , only symptomatic treatments that suppress clinical manifestations are available.
Current lyophilization approaches can preserve histomorphology , DNA , RNA , and proteins though RNA shows moderate degradation after 1-2years.
Currently , other attractive functions of ASCs in the recovery of extrinsic aging and radiation damage are under active investigation.
Currently , our understanding of the role of PHLPP1α in the central nervous system is limited.
Currently , over @number@ million Americans have PIRDDs , and that number is estimated to drastically increase by the end of this decade.
Currently , patches and short-acting intramuscular injections are displaced by gels and long-acting formulations.
Currently , @percent@ of adults over the age of @number@ have at least one chronic disease.
Currently , @percent@ of astronauts are women , and the recently selected astronaut recruits are @percent@ women.
Currently , pharmacological dementia treatment is exclusively focused on medicines.
Currently , pharmacological therapies are able to prevent or slow down bone resorption by inhibiting osteoclast activity.
Currently , research groups label different subsets of structures and use different rules , landmarks , and cues to define their anatomical extents.
Currently , Rome III criteria are the criteria of choice for defining IBS.
Currently , structural fat grafting is the only means for adding volume the depleted upper periorbit.
Currently , studies are underway of dual therapy strategies with lopinavir / ritonavir ( LPV / r ) with distinct antiretroviral agents.
Currently TAVR is considered the treatment of choice for patients who are not surgical candidates and is a proven alternative for high-risk surgical candidates.
Currently , testosterone injections and gel preparations are the most used.
Currently , the authors are interested in quantitatively documenting results and evolving autologous fat transfer to a more predictable procedure.
Currently , the boy is under GH therapy with growth in the 5th percentile and coenzime Q10.
Currently , the cancer is the second cause of death after cardiovascular diseases worldwide.
Currently , the data are not publicly available ; we would welcome collaborations and research proposals.
Currently , the developmental trajectories of neural circuits implicated in autism spectrum disorders ( ASD ) are largely unknown.
Currently , the establishment of guidelines that assure the quality of iPSC-derived blood products for clinical application is in progress.
Currently the focus of sunscreen development is shifting from mere UV protection to protection covering the entire solar spectrum.
Currently , the influence of inflammation on white matter integrity in well-controlled HIV + patients remains unknown.
Currently the issue of fibril length is contentious , but this study provides evidence that the fibrils are extremely long and likely continuous.
Currently , there are few effective treatments available for these diseases and their incidence is rising.
Currently , there are limited data on the influence that nutrition has on telomere length.
Currently , there are limited studies examining the association between life events , social support and late-life depression in Brazil.
Currently there are nine nursing programs across the state in public and private universities and colleges.
Currently , there are no disease-modifying therapies available for Alzheimer's disease.
Currently , there are no effective pharmaceutical cures.
Currently , there are no effective treatments for Alzheimer's disease and related disorders and age continues to be a robust risk factor.
Currently , there are no methods available to quantitatively assess the GSH concentration in live cells.
Currently , there are no more effective treatments against these diseases.
Currently , there are no Polish reference values reflecting age-related changes in the intensity of depressive symptoms in healthy men.
Currently there are no recommended levels of intake [ i.e. , Dietary Reference Intakes ( DRIs ) ] as there are for nutrients and fiber.
Currently there are no registered treatments for sarcopenia.
Currently there are only limited sources of data regarding nocturia incidence.
Currently , there is a call to discover novel biomarkers of MCI in order to improve research criteria.
Currently , there is a debate on the possibility of accelerated aging in the HIV-infected population.
Currently , there is insufficient evidence to support routine screening using a single-item approach.
Currently , there is no cure for AD ; while current therapies may temporarily ameliorate symptoms , death usually occurs approximately @number@ years after diagnosis.
Currently , there is no enforcement of physical standards within Australian fire services post-recruitment , possibly leading to inappropriate fitness and body composition.
Currently , there is no population-based screening.
Currently , there is no standard approach to assessing cognitive function in older aged individuals to best predict incident dementia.
Currently , the underlying mechanisms of ageing that contribute to the initiation or acceleration of cardiac disease are essentially unresolved.
Currently , two focus groups have been carried out that have been analyzed according to Hägerstand's and Gidden's considerations.
Currently , VATS has gained wide acceptance and several institutions in Japan have started using robotic surgery for lung cancers.
Current medical models frequently overlook functional limitations and the home environment even though they partially determine healthcare usage and quality of life.
Current medical therapies for ED largely seek to maximize endogenous NO signalling.
Current medications were determined from drug containers and prescriptions during interviews conducted by a trained nurse.
Current methods for analyzing systems-level BNs deal with their static representations , even though cells are dynamic.
Current methods of assessing skeletal maturation are derived from primarily white populations.
Current methods of ensuring competence are inadequate for supporting ageing doctors.
Current methods of olfactory sensitivity testing are logistically challenging and therefore infeasible for use in in-home surveys and other field settings.
Current models of viral kinetics describe the enhancement of treatment response due to ribavirin.
Current models suggest that fork collisions , either from one or both sides of an ICL , initiate repair processes required for resumption of replication.
Current mood state did not affect MSE overall or when items were worded positively or neutrally.
Current perception thresholds ( CPT ) , SEP latencies and amplitudes were analysed.
Current pharmacological therapies may cause serious adverse effects , are expensive , and fail to effectively improve pain and function.
Current Physical Activity Guidelines recommend @number@ min of moderate-intensity exercise along with strengthening and balance exercises.
Current protocols inducing microchimerism to generate tolerance to solid organ grafts suggest that this could be a feasible therapeutic goal.
Current recommended protein intakes for older people do not account for the compensatory loss of muscle mass that occurs on lower protein intakes.
Current research distinguishes between self , directive and social function of autobiographical memories ( AMs ) .
Current research in animal models and humans has provided compelling evidences supporting the critical function of CyPA in several human diseases.
Current research in several research centers aims at increasing the resin-dentin bond durability.
Current research suggests that the BDNF val66met polymorphism may be only weakly associated with hippocampal atrophy in late adulthood.
Current research targets improving early detection and treatment of MCI , particularly in patients at high risk for progression to dementia.
Current results showed that antioxidative , antibacterial and other health effects are attributed to its caffeine content and caffeine - polyphenols interactions.
Current results show that , despite cognitive loss , persons with mild to moderate AD preserve musical engagement and music seeking.
Current retention rates were acceptable , given the vulnerability of the population.
Current rhinitis symptoms were assessed using a questionnaire.
Current rodent models of menopause fail to adequately recapitulate the menopause transition.
Current smokers are exposed to a two to three times higher risk of AMD than non-smokers and the risk increases with intensity of smoking.
Current-smokers had a higher AWT Pi10 than never-smokers ( mean @number@ mm versus @number@ mm , p = @number@ ) .
Current smokers had higher VAT and VAT% ( p < @number@ ) and lower TBF than non-smokers.
Current smokers were at higher risk of ARC than past smokers.
Current smoking had an approximately 3-fold greater effect on CSF F2-IsoPs compared with age ( P < @number@ ) .
Current smoking significantly declined in males as age increased ( P < @number@ ) .
Current smoking was associated with higher concentrations of androstenedione , sex hormone-binding globulin and testosterone.
Current sociodemographic predictions point to a demographic shift in developed and developing countries that will result in an unprecedented increase of the elderly population.
Current strategies to facilitate bone healing include various biomolecules , cellular therapies , biomaterials and different combinations of these.
Current studies are focused on determining the uptake , metabolism , distribution , toxicity and fate of these nanomaterials in cell and animal model systems.
Current studies of vascular health , aging , and autophagy emphasize how the endothelium adapts to stress and contributes to disease.
Current studies suggest that this conservation may extend to humans.
Current study evaluated the association of within-normal-range serum sodium with cardiovascular risk factors.
Current technologies to identify interaction partners of lamin A and its mutants are hampered by the insoluble nature of lamina components.
Current therapies are largely symptomatic , and novel therapeutic approaches are needed.
Current therapies focus on treatment of the symptoms and attempt to delay the progression of these diseases but there is currently no cure.
Current therapies for Non-Small Cell Lung Cancer ( NSCLC ) still fail to significantly increase its survival rate.
Current therapies target the immune system but do not specifically target AA-related inflammatory pathway.
Current therapies with long-acting bronchodilators and inhaled corticosteroids fail to prevent either disease progression or mortality , as they do not suppress the underlying inflammation.
Current thoughts on the pre- and postoperative care of resurfacing patients are also considered.
Current tools used in determining these values include the standard gamble , time trade off , person trade off , and the visual analogue scale.
Current treatment of hand OA focuses on reducing pain and improving patient function to improve quality of life.
Current treatment options also include desmopressin , a synthetic analog of arginine vasopressin , which can increase urinary osmolality and decrease total urinary volume.
Current treatment preferences were elicited and compared with the patient's POLST orders to assess discordance.
Current treatments are not fully effective , especially among the most vulnerable patients.
Current treatments for PD have side effects in the long term and do not halt disease progression or regenerate dopaminergic cell loss.
Current treatments include artificial tears ; gels ; lubricants ; tear duct plugs ; and anti-inflammatory agents such as steroids , doxycycline , and cyclosporine.
Current trends indicate that widespread participation in organized youth sports is occurring at a younger age , especially in girls.
Current understanding of the role of thrombolytic agents in stroke therapy is also discussed.
Current understanding of the thyroid disruptive properties of perfluoroalkyl substances ( PFASs ) , particularly in aging populations , is limited.
Current understanding of the underlying mechanisms is limited.
Current users of oxygen are older females with multiple comorbidities.
Current V ( D ) J assignment methods work by aligning sequences to a database of known germline V ( D ) J segment alleles.
Current wealth was associated with large inequalities in life satisfaction across all regimes.
Current yearly influenza virus vaccines induce strain-specific neutralizing antibody ( NAb ) responses providing protective immunity to closely matched viruses.
Curriculum objectives and an evaluation checklist were developed to evaluate learners in the three identified areas.
Curve-fitting procedures were applied to obtain a model of P300 development across the lifespan.
Curves depicting the annual hazard of breast cancer death are shaped differently for the early- and late-onset tumors.
Custodial grandmothers think about substitute caregivers for their grandchildren but need assistance communicating a plan focused on their own needs for future care.
Custom algorithms were used for morphological analysis of the ONH NRR and RNFL that included quantification of major retinal vascular contribution.
Custom-designed falls care management software facilitates risk factor assessment , the identification of recommended interventions , clinic note generation , and longitudinal care management.
Customized software was used to analyze the images.
Custom ultra-high resolution optical coherence tomography ( UHR-OCT ) was used to acquire six intraretinal layers of the macula.
Cutaneous adverse drug reactions comprise a significant proportion of all adverse drug reactions.
Cutaneous aging includes intrinsic aging , and photo-aging.
Cutaneous aging translates drastic structural and functional alterations in the extracellular matrix ( ECM ) .
Cutaneous angiomyolipoma ( AMP ) of the ear is an extremely rare benign mesenchymal tumour.
Cutaneous cancers , however , are unusual in the Indian population , especially melanomas , but many are missed.
Cutaneous leishmaniasis is one of many dangerous parasitic diseases.
Cutaneous lupus erythematosus is a previously undiagnosed side-effect of ranibizumab.
Cutaneous manifestations of DM are the most important aspect of this disease and can precede from several months to years muscle or systemic involvement.
Cutaneous melanoma ( CM ) is a highly curable skin cancer of melanocytes if diagnosed early.
Cutaneous samples were taken from the legs of @number@ autopsy cases.
Cutaneous sensation deteriorates with age.
Cutaneous vascular conductance ( CVC = flux / mean arterial pressure ) was expressed as a change from baseline ( ΔCVCbase ) .
Cutaneous vascular conductance was calculated as CVC = LDF / mean arterial pressure and expressed as change from baseline ( ΔCVC ) .
Cutera provided the equipment used in this study and funding to Dr. Goldberg.
Cutis laxa ( CL ) is a connective tissue disorder , characterized by loose , inelastic , sagging skin.
Cut-off scores taking into consideration these variables were defined.
Cutoffs for significant change in each parameter were estimated from variability in healthy controls over @number@ year.
Cut-offs on the ASQ-3 at @number@ months were estimated by receiver operating characteristic curves.
Cut-offs were determined using receiver operating characteristic ( ROC ) curve analyses.
Cut-off values defining these conditions may require adjustment in such groups.
Cut-off values of FIM scores to determine if elderly inpatients were able to return home after discharge were determined using a receiver operating characteristic curve.
Cutometry , corneometry , and ultrasound measurements showed significant improvements at week @number@ time point ( P ≤ @number@ ) against baseline.
Cut points for high , moderate , and low activation were assigned at + / - ½ standard deviation of the mean.
Cut points from previous studies / guidelines were used to assess predictive power.
Cuts cooked according to a dry heat cooking method were reported juicier ( both initial and sustained ) than those cooked by moist heat methods.
CV adverse events were reported by participants.
CVany was associated with further longitudinal AVLT LTM decline in APOE ε4 carriers ( p = 0.02 ) , but had no effect in noncarriers.
CVD and cancer mortality were defined by ICD-9 codes 390-459 and 140-239 , respectively.
CV diseases were the only significant associated factor for high monocyte count.
CVD most adversely affected tasks of cognitive flexibility and inhibition indirectly through CPS.
CVD outcome was generally unrelated to PIIINP but became marginally inversely related to ICTP in the most adjusted model.
CVD risk factors , aortic pulse-wave velocity ( PWV ) , and ankle-arm index ( AAI ) were obtained at study baseline.
CVD risk factors warranting treatment with these EBTs were frequently associated with use of EBTs.
CVD risk in most persons with WCH is comparable to age- and risk-adjusted normotensive control subjects.
CVD was present in @number@ patients.
CVD was significantly , negatively related to the EF composite score ( β = @number@ @percent@ CI [ @number@ @number@ ] ) .
C ) , vitamin E ( Vit.
CVRC and hemodynamic stress distribution seem to be more robust parameters than CBF alone for assessment of disease severity.
CV%RMS and LSC were calculated.
C , which presented a remarkable decrease.
CX3CR1 gene deletion or anti-Aβ immunotherapy causes expansion of microglia coverage and reduced neuritic dystrophy.
CXCL10 mRNA expression was analyzed by qPCR in peripheral blood cells.
CXCL13 was one of these upregulated genes and is expressed specifically in the thymus.
CXCR5 expression on T cells was increased in patients versus controls reflecting reduced endogenous IL-2 signalling under immunosuppressive therapy.
Cyanide , a potential bioterrorist agent , can produce a chronic delayed-onset neurological syndrome that includes symptoms of Parkinsonism.
Cyclase associated protein ( CAP ) is a highly conserved protein with roles in actin dynamics and many cellular processes.
Cyclical hypoxia and sympathetic stimulation has deleterious effects on cardiovascular , cerebrovascular and metabolic functions.
Cyclic guanosine monophosphate ( cGMP ) , which is regulated by nitric oxide ( NO ) , also inhibits PDE III.
Cyclin D1 positive neurons are colocalized with AGEs or directly surrounded by extracellular AGE deposits in AD brain.
Cyclin-dependent kinases ( CDKs ) are a family of serine / threonine kinases whose activity is regulated by CDK inhibitors ( CKIs ) and cyclins.
Cycling cells use Pin1 to help coordinate cell division.
Cycling endurance exercise , which is associated with AMPK activation , increased TERRA levels in skeletal muscle biopsies obtained from @number@ healthy young volunteers.
Cyclin K was previously thought to associate with CDK9 to regulate gene expression.
Cycloheximide chase experiments revealed more rapid turnover of TDP-43 mutant proteins than their wild-type counterpart.
Cyclooxygenase-2 ( COX-2 ) has been associated with cell growth regulation , tissue remodeling , and carcinogenesis.
Cyclooxygenase-2 ( COX-2 ) may be involved in ultraviolet-induced inflammation , photocarcinogenesis and the aging process.
Cyclooxygenase-2 ( COX-2 ) overexpression is implicated in increased risk and poorer outcomes in breast cancer in young women.
Cyclophilin A ( CyPA ) is a ubiquitously distributed protein belonging to the immunophilin family.
Cyclophilins are also chaperones.
Cyclopleged right eyes were used with 4-mm effective pupil sizes.
Cycloplegic refraction was done for primary and junior high school students and non-cycloplegic refraction was done for high school students.
Cyn also inhibited the production of proinflammatory cytokines such as interleukin @number@ and tumor necrosis factor-α from UVB-treated keratinocytes.
Cynaropicrin ( Cyn ) , a sesquiterpene lactone , is the major bioactive phytochemical in the artichoke ; however , its pharmacological mechanism remains unknown.
Cynical distrust was measured at baseline using Cynical Distrust Scale.
CYP17A1 activities , assessed with ratio @number@ were lower in older participants.
CYP17A1 activity is heritable and diminished in the elderly.
CYP1A2 1C and CYP1A2 1F genotypes were analyzed.
CYP21A2 gene mutations in a child with congenital adrenal hyperplasia ( CAH ) , and the child's parents , were detected in the study.
CYP21A2 genotyping identified four duplicated CYP21A2 genes ( @percent@ ) and @number@ chimeric CYP21A1P / CYP21A2 genes ( @percent@ ) .
CYP21A2 mutations cause CAH , and TNX deficiency has been identified as a cause of hypermobility type Ehlers-Danlos syndrome ( EDS ) .
CyPA and CD147 were also positively correlated in all @number@ groups.
CyPA has peptidyl prolyl cis-trans isomerase ( PPIase ) activity , which regulates protein folding and trafficking.
CypD-dependent mPTP can play a crucial role in ischemia / reperfusion injury.
Cyperus rotundus is used as an analgesic and sedative in oriental medicine and has been reported to exhibit antinociceptive and anti-inflammatory effects.
Cys113 oxidization is further confirmed by generating antibodies specifically recognizing oxidized Cys113 of Pin1.
Cys-Gly is a recognised ligand at the N-methyl-D-aspartatic acid ( NMDA ) subclass of glutamate receptor , a system associated with depression.
Cys residues are another potential source of DHA , and evidence for this was found in many lens crystallins.
Cystalgia leads to a large number of consultations to general practitioner , gynaecologist and urologist.
Cystatin C expression , secretion , and its polarity were analyzed following culture on AGE-containing BrM mimics ( AGEd versus non-AGEd ) .
Cystatin C was higher in patients with falls ( @number@ ± @number@ vs. @number@ ± @number@ p = @number@ ) .
Cystic fibrosis ( CF ) is the result of mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) .
Cystic fibrosis transmembrane conductance regulator ( CFTR ) has been demonstrated to be expressed in mature spermatozoa and correlated with sperm quality.
Cystic fibrosis transmembrane conductance regulator ( CFTR ) is expressed ubiquitously throughout the body.
Cytarabine concentrations in plasma were negligible.
Cytochrome c release is generally considered as a pivotal step in apoptosis.
Cytogenetic analysis of differentially stained metaphase chromosomes on G-banding ( passage 6-7 ) showed that healthy donor's cells had predominantly normal karyotype.
Cytogenetic analysis revealed mitomycin C ( MMC ) -induced chromosomal breakage ; however , an additional sister chromatid cohesion defect was also observed.
Cytokine analysis on serum samples was performed.
Cytokine and chemokine secretions by stimulated PMN were altered.
Cytokine dysregulation is believed to play a key role in the proposed remodeling of the immune-inflammatory responses accompanying old age.
Cytokine levels in serum and those produced from peripheral blood mononuclear cell ( PBMC ) were measured.
Cytokine levels were measured in cervicovaginal lavage samples by MILLIPLEX™ MAP Human Cytokine / Chemokine multiplex immunoassay.
Cytokine messenger RNA levels in the spleen were also examined.
Cytokine profiles in the healthy state may foreshadow differential responses to pathogens.
Cytokine profiles were identified by principal component ( PC ) analyses , and expressed as above / below the median.
Cytokines also interfere with neurogenesis during aging and in neurodegenerative diseases.
Cytokines are crucial for the regulation of inflammation development in humans.
Cytokines CCL11 ( eotaxin ) and HMGB1 ( alarmin1 ) are molecular markers of ageing and neurological , cardiovascular and immune diseases.
Cytokines play an important role in differentiation , maturation and survival of a wide range of cells , including cells of the immune system.
Cytolethal distending toxins ( CDTs ) are common among pathogenic bacteria of the human and animal microbiota.
Cytology and HPV genotyping was performed using LBC and HPV Multiplex Genotyping ( MPG ) , respectively.
Cytology was ASCUS or worse in @percent@.
Cytomegalovirus ( CMV ) and Epstein-Barr virus ( EBV ) serologies were determined by ELISAs.
Cytomegalovirus ( CMV ) has been linked with vascular pathology and is a common complication of renal transplantation.
Cytomegalovirus ( CMV ) infection has been implicated in accelerated T cell ageing.
Cytomegalovirus ( CMV ) infection sometimes causes large expansions of CMV-specific T cells , particularly in older people.
Cytomegalovirus ( CMV ) is a herpes virus that has been implicated in biological aging and impaired health.
Cytomegalovirus ( CMV ) is a β-herpesvirus present in a latent form in most people worldwide.
Cytomegalovirus ( CMV ) -seropositivity has been shown to have a negative effect on influenza vaccine-specific antibody responses.
Cytoplasmic FUS inclusions formed spontaneously depending on both , severity of FUS mutation and neuronal aging.
Cytoskeletal rearrangements influence the state of gap junction contacts which regulate cell signaling and metabolic flow of information across cells in tissues.
Cytoskeletal restructuring was also induced.
Cytotoxical potential of immunocompetent cells will be realized in the first stage , to avoid a bacterial infection.
Cytotoxic CD8 T lymphocytes that are present in tumors and capable of recognizing tumor epitopes are nevertheless generally important in eliciting tumor rejection.
Cytotoxic chemotherapy may directly exert long-term toxic effects on bone.
Cytotoxic effects of RCS are due to their capacity to react with cellular constituents , forming advanced lipoxidation end-products ( ALEs ) .
Cytotoxicity assay showed that @number@ and @number@ possessed moderate to weak cytotoxicity against these cancer cells.
Cytotoxicity assays were conducted with an immortalized cell line of human keratinocytes ( HaCaT ) .
Cytotoxicity endpoints , evaluating the cell viability and IC50 ( @percent@ inhibitory concentration ) have been performed for the exposed synthesized nanocomposite.
Cytotoxicity was assessed with the direct cell contact method using cell viability and neutral red ( NR ) uptake assay.
Cytotoxic T lymphocytes are critical in eliminating tumors , but T cell function is also compromised with aging.
D2 / 3 receptor availability was quantified as binding potential using the simplified reference tissue model.
D2 and D3 are widely expressed and in a dynamically and tightly coordinated fashion , thereby allowing cells to customize their own TH activity.
DA administration was required in @percent@ of patients with PRS ; however , no patients with NFPAH required DA administration.
DA are associated with adverse outcomes , such as poorer nutrition intake and reduced work efforts.
DA are more frequent among women than men , and individuals affected by one are often affected by the other.
Dabigatran and warfarin are oral anticoagulant drugs widely used for the prevention of stroke in patients with atrial fibrillation.
Dabigatran prolonged clotting time 5-fold but reduced clot growth velocity only slightly.
DA conversely modulated the p-JAK2 / p-STAT3 levels in PCNs.
DA could not learn arbitrary relations nor use existing knowledge to support novel inferences.
DAF-16 regulates regeneration independently of lifespan , indicating that neuronal aging is an intrinsic , neuron-specific , and genetically regulated process.
DAF-2's function in regeneration is mediated by intrinsic neuronal activity of the forkhead transcription factor DAF-16 / FOXO.
Daily broad-spectrum sunscreen use is an important intervention to prevent squamous cell carcinoma and invasive melanoma.
Daily calorie count ( kcal ) was calculated using the Willett Semi-Quantitative Food Frequency Questionnaire.
Daily clinical practice is already recognizing this on a daily basis , yet clinical research and guidelines are still lagging behind.
Daily consumption of policosanol for @number@ weeks resulted in lowered blood pressure , reduced serum TG level and CETP activity , and elevated HDL-C contents.
Daily DHEA-S levels covaried significantly with daily positive mood but not with depressive symptoms.
Daily dietary fiber intake was assessed using a validated food frequency questionnaire.
Daily drinking was associated with chronic pain ( OR = @number@ @percent@ CI : @number@ @date@ ) .
Daily exposure to cigarette smoke ( CS ) can lead to alteration in diverse biological and physiological processes.
Daily fish-oil consumption in late life was associated with lower fracture risk in men ( HR : @number@ @percent@ CI : @number@ @number@ ) .
Daily fish-oil consumption in midlife was associated with lower fracture risk in women ( HR : @number@ @percent@ CI : @number@ @number@ ) .
Daily flavonoid and methyl nutrients intakes were assessed through the Food Frequency Questionnaire ( FFQ ) .
Daily functioning was operationalized as basic and instrumental activities of daily living ( ADL and IADL ) and mobility.
Daily GDF11 treatment attenuated cellular senescence and airspace enlargement in an elastase-induced mouse model of emphysema.
Daily goal progress is contingent on daily social experiences , but these sensitivities are in part shaped by goal orientation.
Daily ( hour-by-hour ) profiles of activity were compared between homemakers and EW.
Daily intake of fruits , vegetables , and vitamins were estimated using data from 24-hour recalls and food frequency questionnaires.
Daily interactions provide chances to laugh , argue , empathize , and love.
Daily living skills are important to ageing adults with intellectual disabilities ( ID ) .
Daily mean pain and health were also found to be predictors of pain variability.
Daily oral administration of T1-11 or JMF1907 prevented neuronal death of pontine nuclei in the SCA3 mouse with a dose-dependent manner.
Daily or weekly use was associated with schooling and use of tobacco between women ; age and the use of tobacco between men.
Daily physical activity decreased by @number@ ± @percent@ ( Y ) and @number@ ± @percent@ ( O ) ( p < @number@ ) .
Daily physical activity was evaluated using life-space assessment ( LSA ) which assessed the life-space level , degree of independence , and frequency of attainment.
Daily rhythms of physiological and behavioral processes such as sleep and arousal are controlled by the circadian clock.
Daily telephone interviews assessed daily stressors and mood.
Daily temperature measures are commonly used when examining the association between temperature and mortality.
Daily TSH secretion was @number@ mU / L ( range , @number@.0-207 mU / L ) .
Dairy consumption has also been shown to promote FM loss in different subpopulations and to be positively associated with fat oxidation.
Dairy intake was related to sex , fat-free mass , and daily intakes of energy , protein , and carbohydrates.
Dalteparin sodium has been evaluated in small studies within this population but no strategy for reduced dosing has been developed.
DALYs were estimated as the sum of YLDs and YLLs.
Damage accumulation is thought to be driven , among others , by oxidative stress.
Damaged and misfolded proteins accumulate with age , impairing cell function and tissue homeostasis.
Damaged DNA has a profound impact on mammalian health and overall survival.
Damaged proteins are degraded by the ubiquitin-proteasome system or through autophagy-lysosome , key components of the proteostasis network.
Damage of specific cortico-thalamic tracts explained global cognitive dysfunction and impairment of selected cognitive domains better than all other MRI variables.
Damage-response mechanisms become deregulated as a result of failed recruitment of elongation factors and possibly ancillary to disruption of chromatin organization.
Dampening of circadian rhythms has been associated with aging and disease.
Dampening of insulin / insulin-like growth factor-1 ( IGF1 ) signaling results in the extension of lifespan in invertebrate as well as murine models.
DAMPs represent ideal biomarkers of ageing and provide an attractive target for interventions in ageing and age-associated diseases.
Dance-based therapy has the potential to slow the progression of functional limitations in older adults.
Dance holds a promise as a culturally appropriate form of PA that challenges individuals physically and cognitively.
Dance sessions focus on instruction , including four styles of dance , and couples dancing.
Dance therapy improved fear of falling in two out of three included RCTs.
Dance therapy is reflected by higher plasma viscosity.
Dancing is a complex sensorimotor activity involving physical and mental elements which have positive effects on cognitive functions and motor control.
Dancing is a mode of physical activity that may allow older adults to improve their physical function , health , and well-being.
DA neurons had a distinctive miRNA signature and a set of miRNAs was dysregulated in PD.
Daphnoretin and coumarin showed a negligible alteration on protein biomarkers.
DAPT beyond @number@ months does not appear to alter the risk of stroke.
Dark adapted visual threshold was measured using a forced-choice preferential procedure.
Dark irides were significantly associated with high MPOD ( r = @number@ p < @number@ ) .
DASH adherence for each individual was based on scoring of intakes of @number@ nutrient or food components.
DAS holds considerable promise for being such an agent.
DAS inhibits aberrant complement activation by selectively blocking factor D of the alternative complement pathway and C9 of the membrane attack complex.
DAS is much more potent , inhibiting erythrocyte hemolysis by complement-activated serum with an IC50 in the 100-170 nanomolar range.
DAs were acquired and verified based on cellular biomarkers and multilineage differentiation potential.
Data about pain and quality of life were obtained from a semi-structured interview and questionnaires.
Data about the factors associated with its use remain scarce , especially in Europe.
DATA ABSTRACTION : Two independent investigators abstracted data on study , patient , and treatment characteristics.
DATA ACCESS : Inclusions begun at the end of @number@ and more than @number@ @number@ participants were already included by @date@ .
Data acquisition for each participant lasted @number@ minutes.
Data also derive from a variety of documentary sources.
Data also implied that this effect was associated with altered actions of FoxO3 and GSK-3β.
Data also indicate that a pro-oxidant environment characterizes older neurons and favors α-synuclein nitration.
Data also showed that older adults , particularly those with lower numeracy and technology experience , encountered greater problems using the system.
Data also suggest that aging may increase variability in certain biomechanical measures , whereas symmetry is not affected by age.
Data analyses consisted of descriptive statistics , t-tests , and one-way analysis of variance.
Data analyses included bivariate group comparisons and hierarchical regression.
Data analyses included odds ratios ( OR ) , Chi-square and linear regressions.
Data analyses were by intention-to-treat.
Data analyses were performed in @number@ subjects randomly recruited from Tianjin municipality in China.
DATA ANALYSIS : Extracted data were synthesised using a narrative approach.
Data analysis identified three heterozygous mutations from these individuals , all within the same gene.
Data analysis included correlation and logistic regression analyses.
Data analysis included linear regression and logistic regression on continuous and categorical outcomes , respectively.
Data analysis included spatial normalization of gray matter-corrected relative CBF maps , whole-brain average , and voxelwise comparison of both arterial spin-labeling sequences.
Data analysis included task-related general linear model and functional connectivity tensorial independent component analysis.
Data analysis included whole-brain voxel-based morphometry and ROI analysis of GM.
Data analysis is based on grounded theory framework.
Data analysis used methods drawn from grounded theory.
Data analysis was based on the signs , meanings , and actions model.
Data analysis was carried out using SPSS-18 software.
Data analysis was completed based on interviews with @number@ older residents from @number@ AL communities.
Data analysis was completed in @date@ .
Data analysis was conducted between @date@ and @date@ .
Data analysis was conducted from @date@ , to @date@ .
Data analysis was conducted from @date@ , to @date@ .
Data analysis was conducted from @date@ , to @date@ .
Data analysis was conducted from @date@ , to @date@ .
Data analysis was conducted using concept mapping techniques in the cross-cultural context where two languages were simultaneously used.
Data analysis was conducted using the Statistical Package for Social Sciences ( SPSS ) version @number@
Data analysis was facilitated by qualitative analysis software.
Data analysis was performed for a cross-sectional and longitudinal study of the outcomes for the different treatment groups.
Data analysis was performed from @date@ , to @date@ .
Data analysis was performed from @date@ , to @date@ .
Data analysis was performed from @date@ , to @date@ .
Data analysis was performed using the Review Manager @number@ software.
Data are collected via questionnaire , examinations and venepuncture.
Data are derived from the Surveillance , Epidemiology , and End Results limited-use database.
Data are drawn from a @number@ special retirement module implemented analogously in national labor force surveys.
Data are drawn from the 2008-2009 Canadian Community Health Survey respondents who met the study criteria ( n = @number@ ) .
Data are equivocal on whether voluntary activation is preserved or decreased in old compared to young adults.
Data are expressed as mean values±standard deviations , medians and interquartile ranges ( IQRs ) , and percentages and compared using univariate and multivariate analysis.
Data are for @number@ CSBA participants aged ≥ @number@ years.
Data are from @number@ early in the history of federal long-term care rebalancing initiatives , reflecting perceptions at that time.
Data are from the Boston Longitudinal Study , a subsample of the Midlife in the United States study.
Data are from the Longitudinal Aging Study Amsterdam ( LASA ) and include @number@ Dutch participants aged 55-85 over a period of six years.
Data are from the Netherlands Study of Depression and Anxiety , including @number@ current MDD patients , @number@ remitted MDD patients and @number@ control subjects.
Data are from the prospective community-based Honolulu Asia Aging Study of Japanese American men born 1900-1919.
Data are given as mean ± SD or median [ interquartile range ] .
Data are lacking how response should be defined.
Data are lacking regarding the risks and benefits of discontinuing statin therapy for patients with limited life expectancy.
Data are mean ± SE ; a P-value < @number@ was considered significant.
Data are needed on characteristics of all offspring to test theories about parent-child relationships.
Data are not sufficient to choose one tool over another , but all of them work and can uncover symptoms that can be fixed.
Data are presented as median ( quartiles ) .
Data are presented as proportions and percentages.
Data are presented by the four key dimensions of gender , race , residence , and educational attainment.
Data are presented from individuals who were followed with neurocognitive and neuroradiologic measurements , followed by neuropathologic evaluation at the University of Kentucky.
Data are provided evidencing significantly high conversion rates from these pre-AD stages to actual AD.
Data are shown revealing that fibrosis can also be induced by reduced sodium channel and connexin43 expression.
Databases of MEDLINE , EMBASE , BIOSIS , the Cochrane Library , and the Chinese National Knowledge Infrastructure were systematically searched.
Databases searched included PubMed , Google Scholar , Ovid , and Athens.
Databases were searched from @date@ to @date@ .
Data came from males and females aged 13-99 years who participated in the 2005-2010 National Health and Nutrition Examination Survey ( NHANES ) .
Data came from @number@ non-demented , community-dwelling elderly women recruited in France to the 3C Study.
Data came from @number@ participants aged @number@ through @number@ from the Age , Gene / Environment Susceptibility ( AGES ) - Reykjavik Study.
Data came from @number@ university professors paired with one research assistant each.
Data came from seven waves of the Health and Retirement Study ( HRS 1998-2010 ; n = @number@ Observations = @number@ ) .
Data came from the @number@ National Health Interview Survey ( NHIS ) in Taiwan.
Data can enhance the interpretation of clinical fundus-AF and provide a basis for future quantitative studies.
Data clusters and patterns of co-occurring codes were explored through an iterative analysis process.
Data collected between @number@ and @number@ revealed a significant increase in mean depressive symptoms.
Data collected by the app allowed us to assess performance differences due to the aging of the neuromuscular system.
Data collected from two prisons in Switzerland housing women prisoners were studied.
Data collected included demographics , incidence of falls , HAIs , and risk of social isolation.
Data collected in @number@ and @number@ within the Health of Young Victorians longitudinal cohort study.
Data collected in the present investigation could serve as a database for the quantitative description of human facial morphology during normal growth and development.
Data collected over a 30-year period have demonstrated the increasing prevalence of hypertension with age.
DATA COLLECTION : All subjects completed an adaptive behavioral gap detection procedure in order to determine their behavioral gap detection threshold ( BGDT ) .
DATA COLLECTION AND ANALYSIS : Accuracy , reaction time , and false alarm rate were measured and analyzed using a mixed design analysis of variance.
DATA COLLECTION AND ANALYSIS : Data from a self-report question on hearing loss and diagnostic pure tone audiometry was utilized for this study.
DATA COLLECTION AND ANALYSIS : JT extracted the data , which included patient characteristics , outcomes , and harms.
DATA COLLECTION AND ANALYSIS : Scalp electroencephalographic activity was recorded from @number@ electrodes.
DATA COLLECTION AND ANALYSIS : Stimuli used to evoke FFRs were @number@ Hz tone bursts as well as a consonant-vowel / da / sound.
DATA COLLECTION AND ANALYSIS : Temporal processing was evaluated using gap detection , duration discrimination , modulation detection , and duration pattern.
DATA COLLECTION AND ANALYSIS : Two authors independently selected studies , assessed risk of bias and extracted data.
DATA COLLECTION AND ANALYSIS : Two authors reviewed all abstracts independently.
DATA COLLECTION AND ANALYSIS : We collected and analyzed studies according to the published protocol.
DATA COLLECTION AND ANALYSIS : We extracted and described information on the characteristics of the study participants and study setting.
DATA COLLECTION AND ANALYSIS : We used standard methodological procedures expected by Cochrane.
Data collection consisted of @number@ in-depth interviews about individuals ' knee surgery experiences conducted eight months after surgery.
Data collection for primary outcome analyses related to re-hospitalization and mortality is estimated for @date@ .
Data collection included an interview , map-drawing task , and walk along a previously audited , prescribed route to identify key wayfinding strategies.
Data collection included anthropometric measurement , blood pressure measurement , blood analytics , objectively measurement of physical activity , and dietary assessment.
Data collection included socioeconomic and clinical data , anthropometric measures , blood pressure ( BP ) , HIV-status , point-of-care glucose and lipid levels.
Data collection in Wave @number@ included a technique for comparing respondents ' confidant network rosters between waves.
Data collection is ongoing and currently in its fifth year.
Data collection methods included two interviews and an observation.
Data collection occurred over @number@ study visits.
Data collection took place at the University of Konstanz , Germany.
Data collection took place in @number@
Data collection tool was a triploid questionnaire that included demographic data , questions of precede-proceed constructs and SF-36 questionnaire.
Data collection was carried out between September and @date@ .
Data collection was carried out by a research nutritionist using computer assisted personal interviewing in the participant's own home.
Data collection was conducted from medical records and interviews with coordinators doctors and nursing staff in nursing homes.
Data collection was performed automatically during all of the three phases.
Data collection was performed through in-depth semi-structured interviews , followed by content analysis.
Data collection was performed through in-depth , semistructured interviews with @number@ aging parents of children with developmental disabilities , followed by a content analysis.
Data collection was performed through in-depth , semi-structured interviews with @number@ widows , between the ages of 62-91 , followed by content analysis.
Data come from the @number@ National Health Interview Survey and National Health Insurance Research Database.
Data comparing clinical-grade MSC from various ages of donors are scant.
Data comprised a sample of @number@ respondents over age @number@ drawn from Statistics Canada's General Social Survey , Cycle @number@
Data confirm those aging with HIV exhibit high rates of age-associated illnesses @number@ to @number@ years before expected.
Data continue to be added to the Cimbi database and biobank.
Data-dependent acquisition ( DDA ) was used for baseline analysis.
Data derived from @number@ community-dwelling older adults were analyzed through the Rasch measurement model.
Data derived from the first and second waves of the Daily Diary Study of the National Survey of Midlife in the United States.
Data describing bipolar disorder in older adults people are scarce , particularly with regard to functional status.
Data describing measurement methods and properties were extracted and reviewed.
Data don't highlight significant changes in body composition , however , tend to a muscle mass and bone mineral mass reduction.
Data driven modeling analysis , synchronization and coupling analysis and their applications to biosignals in healthy subjects and patients with different sleep disorders are presented.
Data entry and statistical analysis used SPSS version @number@
Data entry was accomplished using Epidata @number@ software , while data analysis was performed using stata @number@ software.
Data examining the efficacy of pharmacological , non-pharmacological and novel treatments for depression are discussed.
DATA EXTRACTION : A methodological quality scoring as well as an assessment of the quality of exercise paradigms were both made.
DATA EXTRACTION AND MANAGEMENT : Two reviewers independently screened titles , abstracts , and full-texts of articles.
Data extraction and risk of bias assessment were completed independently by @number@ reviewers using predefined criteria.
DATA EXTRACTION AND SYNTHESIS : All analytic steps related to measuring morphometric characteristics were obtained via custom algorithms programmed into commercially available software.
Data Extraction and Synthesis : Pairs of reviewers independently screened the studies , abstracted data , and appraised risk of bias.
DATA EXTRACTION AND SYNTHESIS : Two experienced physician reviewers independently and blindly abstracted data on outcome measures using a standardized approach.
DATA EXTRACTION : Articles were analyzed for feasibility , benefits and limitations of preoperative physical preparation techniques.
DATA EXTRACTION : Common community integration measures were identified and ranked for relevance and psychometric properties.
Data Extraction : Data were extracted and evaluated by two authors independently , with discrepancies resolved by discussion.
DATA EXTRACTION : Descriptive epidemiologic data on disability after critical illness.
DATA EXTRACTION : Eligible studies were selected and data extracted independently by @number@ reviewers.The AMSTAR checklist was used to assess the quality of the SRs.
Data extraction evaluated the importance of determinants , strength of evidence , and methodological quality of the selected papers.
DATA EXTRACTION : Four reviewers evaluated eligibility and @number@ reviewers evaluated methodological quality.
Data extraction from nursing records of the sample , using cross mapping with Nursing Interventions Classification.
DATA EXTRACTION : g : Profiler found four muscle gene networks with imprinted loci.
DATA EXTRACTION : In-hospital mortality , length of stay , and long-term mortality outcomes were collected.
DATA EXTRACTION METHODS : We identified new Medicare beneficiaries in the years 2008-2011 and their participation in Medicaid based on Medicare enrollment records.
Data Extraction : @number@ reviewers independently extracted study data and assessed study quality.
DATA EXTRACTION : Qualitative data were extracted using the JBI-QARI.
Data extraction required the most time ( @number@ ± @number@ weeks ) .
DATA EXTRACTION : Two authors independently extracted data.
DATA EXTRACTION : Two independent reviewers selected studies based on inclusion criteria and then extracted data.
DATA EXTRACTION : Two review authors independently screened the search results and performed data extraction and risk of bias assessment.
DATA EXTRACTION : Two reviewers independently extracted demographic , intervention , and outcome data.
DATA EXTRACTION : Two reviewers independently selected studies , determined study quality and extracted outcome and descriptive data.
Data for epidemiological analysis were entered ( double entry ) into computer and organized by EpiData @number@
Data for fracture incidence , bone metabolism biomarkers , and adverse events were also extracted and analysed.
Data for @number@ males and @number@ females aged ≥65 years were collected.
Data for @number@ patients were collected , in @number@ % of which data for weight were available.
Data for the incidence of such conditions exist in cohort studies worldwide , which , however , differ in various aspects.
Data for these @number@ patients managed with both modalities were analysed.
Data for the study come from the Finnish Longitudinal Study of Municipal Employees ( FLAME ) .
Data for the three studies with adults were less conclusive.
Data for this project come from the @number@ National Nursing Home Survey ( n = @number@ ) .
Data for this study were gathered using the World Health Organization QoL-BREF questionnaire.
Data from 3D motion analyses of @number@ adults with cerebral palsy were included.
Data from a limited number of randomized clinical trials reinforce the important role that physical activity plays in weight loss programmes for older adults.
Data from all consecutive cases evaluated for dementia in the secondary health system in the Capital Region of Denmark are entered.
Data from a parallel prospective observational study of @number@ women examine biomarkers and risk factors associated with stroke.
Data from a population-based panel study , the English Longitudinal Study of Aging , on @number@ participants aged 65-79 years were analyzed cross-sectionally.
Data from a second cohort confirmed the need to decrease volume and follicle number with increasing age to diagnose PCOS.
Data from Asia are scarce.
Data from a study conducted to examine the psychobiological and aging influences on unintended falls among physically active older adults were analyzed.
Data from clinical trials were analyzed for efficacy and safety.
Data from comprehensive geriatric assessments were collected from computerized medical charts.
Data from either the LAO projection or the anterior-posterior geometric mean are acceptable for calculating the half-time of gastric emptying.
Data from eligible studies were extracted independently and discrepancies were resolved by consensus.
Data from European methadone populations is sparse.
Data from healthy controls revealed an upper cut-off of @number@ for the TMS representing the extreme of motor ratings for a normal aging population.
Data from Hong Kong and British children are consistent with these hypotheses.
Data from in vitro studies consistently support the notion that zinc is critical for early and late autophagy.
Data from medical records , self-administered forms , and interview were collected and analyzed.
Data from men who underwent a routine health check-up were collected from @number@ university hospitals.
Data from @number@ adolescent girls were analyzed.
Data from @number@ college students were used to assess young adults ' communicative responses to older persons ' painful self-disclosures ( PSDs ) .
Data from @number@ community-dwelling non-disabled people aged @number@ years or more from three group practices in suburban London contributed to this study.
Data from @number@ follow-up surveys were used to identify new stroke and poststroke dementia events.
Data from @number@ Hebrew-speakers aged 5-86 years were analyzed.
Data from @number@ HIV-infected men and @number@ non-HIV-infected male controls were compared.
Data from @number@ independently living women aged @number@ and older were analyzed using principal components analysis ( PCA ) .
Data from @number@ male volunteers ( mean age = @number@ ± @number@ years ) in the PREADViSE clinical trial were used in the current investigation.
Data from @number@ @number@ children were analyzed.
Data from @number@ @number@ children were analyzed. a ) Whole study population aged 4-16 years old.
Data from @number@ ( @number@ CN , @number@ aMCI ) participants were analyzed to quantify differences in semantic clustering ratios on the HVLT-R.
Data from @number@ older community dwellers in Victoria , Australia , in the follow-up survey were used for this study.
Data from @number@ older HIV-seropositive and HIV-seronegative men who have sex with men from the Multicenter AIDS Cohort Study were examined.
Data from @number@ participants ( ages ≥60 years ) were analyzed ( @percent@ men , @percent@ women ) .
Data from @number@ participants collected at baseline were linked with the Danish Cause of Death Registry with the study ending on @date@ .
Data from @number@ patients ( average age @number@.5years ; @number@ males and @number@ females ) were analyzed.
Data from @number@ patients were analyzed.
Data from @number@ patients were available for the statistical analysis.
Data from @number@ population-based cancer registries from @number@ European countries collected in the context of the EUROCARE-4 project were analyzed.
Data from @number@ respondents ( @number@ years old and over ) were collected in @date@ .
Data from @number@ studies were extracted and assessed for quality using standardized tools.
Data from @number@ subjects were analysed.
Data from @number@ trials do not support the concept that interventions led by hospital or community pharmacists for the general older population reduces unplanned admissions.
Data from @number@ were used and were classified according to the significant variables.
Data from @number@ women in the Asia Pacific Cohort Studies Collaboration were thus used to investigate the risk factors for stroke in the region.
Data from one elderly participant was excluded due to the incorrigible head motion.
Data from over half century ago in animal models suggest indeed that radiation effects are reduced during hibernation.
Data from participants who died while enrolled in the Health and Retirement Study were analyzed.
Data from patients with diabetes and non-diabetic controls were also compared.
Data from prior neuropsychological assessments were available for @number@ subjects ; longitudinal analyses were used to model individual change over time for those subjects.
Data from several studies support an association between circulating microRNAs and exercise.
Data from six adult cohorts ( ages 50-92 years ) were included in a two stage meta-analysis of individual participant data.
Data from studies in rodents support a cross talk between BAT and other distal tissues.
Data from the 15-year period 1998 2012 were analyzed.
Data from the 1999-2002 NHANES were used ( N = 2 , 097 ; 60 + yrs ) , with mortality follow-up through @number@
Data from the 2003-2006 National Health and Nutrition Examination Survey were used.
Data from the 2013-2014 National Health Interview Survey ( NHIS ) were analyzed.
Data from the AD Neuroimaging Initiative ( n = @number@ ) were analyzed , including individuals with normal cognition and mild cognitive impairment.
Data from the Australian Department of Health and Aging and the Australian Bureau of Statistics were analysed by statistical division.
Data from the clinical and economic outcomes in Medicare beneficiaries with COPD who reside in long-term care ( LTC ) facilities are limited.
Data from the identified studies were extracted to estimate the trend of HZ incidence in the ≥65-year-old age cohort.
Data from the Korean Social Life , Health , and Aging Project were analyzed.
Data from the literature point to the opposite.
Data from the National Rehabilitation Reporting System and chart review were used.
Data from the @number@ National Health and Aging Trends Study were analyzed.
Data from the @number@ PA and @number@ NP respondents were analyzed ( @percent@ response rate ) .
Data from the other two surveys confirmed the age pattern for stress.
Data from the population-based Saarland Cancer Registry including female patients diagnosed with invasive breast cancer between @number@ and @number@ were included.
Data from the Swedish Patient Register and Prescribed Drug Register were combined for the diagnosis of diabetes.
Data from the Women's Health and Aging Study were used to test a model of factors explaining depressive symptomology.
Data from this complete cadaver are presented in table format.
Data from this population turn out to be useful for considerations about evolutionary hypotheses on the aging phenomenon.
Data from this study established the association of GJA3 down regulation with lens epithelial cells apoptosis and age-related cataract genesis.
Data from this study help us with a clearer picture of trauma in the over-80 elders , a subgroup that deserves special attention.
Data from this study may be useful to develop an atlas of skeletal development and bone age.
Data from two consecutive waves of the Irish Longitudinal Study on Ageing ( TILDA ) were analyzed.
Data from two healthy subjects had to be excluded due to MRI artifacts.
Data from two independent samples of older adults were used.
Data from two intensive care units are evaluated.
Data from various TRT studies based on Korean have shown its efficacy in increasing serum testosterone levels and improving subjective symptoms as assessed by questionnaires.
Data from Waves @number@ and @number@ of ELSA were used in this study with @number@ years of follow-up.
Data from younger and older listeners in a prior investigation [ Gordon-Salant et al.
Data gathered from two comparable treatment centres resulted in @number@ pairs of egg sharing providers and their recipients that could be analysed statistically.
Data gathered included : PRP application , study type , subject number , centrifugation , anticoagulation , activation , PRP composition , and outcomes.
Data have been recorded regarding functional and clinical parameters before , during hospital admission and at discharge.
Data , however , suggest that men with OAB are far less frequently treated than women.
DATA IDENTIFICATION : A search of the English-language literature ( Medline ) and a systematic review of published articles were carried out.
Data including non-steroidal anti-inflammatory drugs ( NSAIDs ) use and the presence of peptic ulcers were collected.
Data indicated service providers acknowledge the importance of mealtimes but recognize numerous shortfalls in current care.
Data indicate that Hydros-TA had a more rapid pain relief compared to Hydros alone.
Data interpretation was based on classical authors and the recent national and international literature on the phenomenon.
Data is analyzed with independent component analysis ( ICA ) .
Data is emerging that Galectin @number@ is elevated in many cancers including solid tumors and the cancers of the blood.
Data limitations are discussed.
Data linking these findings are limited.
Data - manual segmentation was performed on @number@ individuals for the HC , and @number@ for the AG , using the Pruessner protocol.
Data mining of the reported expression data , brain-imaging data , and biomarker data in AD patients was also performed to further validate the results.
Data mining techniques have been applied in recent biomedical studies to solve this problem using a more general approach.
Data ( MPa ) were analyzed by Proc Mixed for repeated measures and the Tukey-Kramer test ( α = .05 ) .
Data needed to inform the phenotype of AD in the setting of HIV are equally few.
Data obtained from this study show the carotid IMT changes in relation to age and sex.
Data obtained show a dose-dependent cytotoxic effect of the novel PPAR antagonist in colorectal and pancreatic cancer models.
Data obtained with cultured cells confirmed the latter evidence , suggesting mTOR regulation by oleuropein aglycone.
Data of demographic and clinical characteristics were collected by a form designed for this study.
Data of motor and nonmotor PD symptoms were collected in @number@ patients in two different European prevalent cohorts.
Data of @number@ older adults , who were assigned to a dancing group or a health-related exercise group , are presented in the study.
Data of RA patients exposed TNF inhibitors during pregnancy has been accumulating in recent years.
Data on ADLs were collected through interviews.
Data on age , gender , previous professional and personal experiences as well as nursing school teaching were collected.
Data on age , sex , and medical history of microvascular disease and cancer were obtained from the medical files.
Data on age , sex , blood pressure and blood test results were collected at baseline.
Data on angiographic vasospasm , DINDs , and TCD abnormalities were prospectively recorded as well as baseline characteristics and treatment data.
Data on anthropometric measures , fitness performance , as well as quality of life and attitudes to aging survey data were collected.
Data on antidiabetic , dementia , cardiovascular , and psychotropic medications were extracted from the Swedish Prescribed Drug Register.
Data on associations between dietary intake of macronutrients and body composition in the general population are sparse.
Data on a total of @number@ older adults from a national survey on non-institutionalized and from a study on institutionalized older people were analyzed.
Data on a total of @number@ participants were available for analysis.
Data on blood pressure ( BP ) , cholesterol , and glycemic control were collected through standardized chart review of outpatient medical records.
Data on breastfeeding and cultural practices were collected via questionnaire.
Data on cardiovascular complications and death were extracted from national registers and a local study of retinopathy.
Data on chronic conditions have been collected through physical assessment , questionnaires , and medical files.
Data on CKD awareness among the elderly are sparse.
Data on clinical outcomes , mortality , symptomatic intracerebral hemorrhage , and recanalization were abstracted.
Data on dementia diagnosis , dementia type , and demographic determinants were extracted from SveDem.
Data on demographic characteristics , use of medication , and general and oral health status were obtained at baseline.
Data on demographics , VRFs and APOE genotypes were collected through interviews , clinical examination and laboratory tests.
Data on energy , sodium , saturated fat , and trans fat content were collated from @number@ through @number@ using an archival website.
Data on ESRD was obtained by record linkage with the ESRD cases registered by National Registry of Diseases Office , Singapore.
Data on functional disability were retrieved from the public Long-term Care Insurance database , in which participants were followed up for @number@ years.
Data on functional disability were retrieved from the public Long-term Care Insurance database in which participants were followed up for @number@ years.
Data on gait were collected on an electronic walkway on which participants walked at their usual pace.
Data on hearing loss among aging human immunodeficiency virus-seropositive ( HIV + ) adults are limited.
Data on HF and mortality were collected through annual examinations or contact during the 10-year follow-up period.
Data on how gender affects the sleep patterns of Taiwanese are limited.
Data on incidence of stroke were retrieved from an official database in @number@
Data on interventions and outcomes were extracted from the included studies.
Data on length of hospital stay , body mass index and outcomes were collected prospectively and reviewed retrospectively.
Data on leukocyte telomere length of ex-POWs and @number@ controls was collected @number@ years after the war.
Data on lifestyle behaviors were collected concomitantly between @date@ and @date@ .
Data on living arrangements were collected in interviews.
Data on long-term survival of younger patients with ischemic stroke ( IS ) are limited.
Data on LOS were abstracted from the medical record.
Data on mortality was provided by the National Death Registry , causes of death were classified by the National Center of Statistics of Finland.
Data on mortality were extracted six years later from the National Death Index.
Data on @number@ elderly from two waves of the population and household survey , EpiFloripa Idoso , were analyzed.
Data on @number@ follow-up interviews are presented.
Data on @number@ participants aged ≥ @number@ years were included in this analysis.
Data on @number@ populations from @number@ articles were included for analysis , on the basis of adequate description of study design and blood pressure measurement.
Data on other HPV-related anogenital cancers including those of the vulva , vagina , anus , and penis , are limited.
Data on outcomes routinely collected in the electronic patient records were not accessible during the study , and appeared to be often missing during analyses.
Data on patient age and body mass index , surgical techniques used ( when available ) , and intraoperative and postoperative complications were collected.
Data on patient characteristics including demographics , presenting clinical features , Mini-Mental State Examination , clinical dementia ratings , and neuropsychiatry inventory scores were collected.
Data on physical , behavioral , psychiatric , and aging characteristics were collected through semi-structured interviews with the individuals with PWS and their main carers.
Data on predictors of memory complaints were collected at baseline and analyzed using logistic regression analyses.
Data on prevalence rates of psychopathology is still scarce.
Data on prevalent diabetes at baseline were obtained from the study participants and their general practitioners.
Data on processes of growth and maturing of children of younger school age , basic for formation of the person are generalised.
Data on residency programs specific to perioperative nursing are lacking.
Data on study population , design , measures of health status , factors within the four previously stated domains and results were extracted.
Data on the actual infarction are not necessitated now for this variable.
Data on the association of body physique ( e.g. , height and weight ) and DLSS are limited.
Data on the clinical course at study investigation were assessed by clinical examination and laboratory evaluation.
Data on the epidemiology of HF are largely lacking for Germany.
Data on the feasibility and efficacy of current standards of care are therefore lacking in frail patients.
Data on the increase in haemoglobin level after therapy was either collected from original publications or by contacting the corresponding authors.
Data on the safety of the aging general aviation population and increased drug usage will also be described.
Data on these were collected and classified as hADRs or ADRs to liposoluble drugs ( lADRs ) .
Data on tobacco consumption were self-reported and interviewees were then classified as never smokers , former smokers or current smokers.
Data on twins and on relatives of long-lived subjects suggested that the occurrence / accumulation of these mutations may be genetically influenced.
Data on unacylated ghrelin response are scant but resemble those of total ghrelin.
Data on use of anti-osteoporosis medicines and calcium and vitamin D supplements were collected at baseline and @number@ months.
Data pertinent to this premise are reviewed.
Data pooling enables greater precision and improved generalizability of NART norms than do methods that use single older adult samples.
Data presented herein confirm the safety and efficacy of RecoSMA treatment for facial rejuvenation.
Data presented in this review support the assumption that chromothripsis could operate in human germlines and during early embryonic development.
Data recorded at baseline are presented in this paper.
Data recorded from pediatric and adult files were GH doses , pituitary magnetic resonance imaging and function , and metabolic and bone status.
Data refer to the individuals who completed the examination at baseline.
Data regarding cancer incidence and mortality were obtained from the database of the International Agency for Research on Cancer ( IARC ) .
Data regarding cardiovascular risk factors , comorbidities , type of treatment , and possible procedure-related complications were collected from patients ' files.
Data regarding in- and outpatient care were collected from the Swedish National Patient Register.
Data regarding mesothelioma incidence from 1994-2013 were acquired from the Korea Central Cancer Registry ( KCCR ) .
Data regarding mortality and dependency were collected at 3-year follow-up.
Data regarding patient demographics , pretreatment regimens , detailed operative data , and posttreatment findings were obtained.
Data regarding their health were compared.
Data regarding the use of 532-ng laser photo-selective vaporization of prostate are scant but promising.
Data regarding workers ' job characteristics were from self-report and Occupational Information Network measures.
Data registration was carried out using the clinical pathways of the CvGT database.
Data reported here compare the health and health-care utilization of the general aging population in Ireland with those who are aging with ID.
Data reported here point to the importance of additional work to elucidate the role of PAPP-A in intervertebral disc aging and degeneration.
Data reported recently suggest that transfusion with older red blood cell units may jeopardize the outcome of severely ill patients.
Data reveal a complex trajectory of Aβ and iFC correspondence , affecting both Aβ accumulation and iFC impairments.
Data revealed similarities and distinctions between the basic intentions of relying on canes and walkers and the associated purposes served by canes and walkers.
Data revealed that subjects with PD had lower ApEn values than controls.
Data saturation was achieved after nine participant interviews.
Data sets included in arrayMap have been assembled from public repositories as well as additional resources , and integrated by applying custom processing pipelines.
Data showed moderately strong associations between increased activation , self-care , and QOL.
Data showed that base editor could precisely correct HBB @number@ ( A > G ) mutation in the patient's primary cells.
Data showed that either groups had a functional impairment ( Barthel index < @number@ points ) .
Data showed that insight emerged significantly less frequently after a night of sleep in older adults compared to young.
Data showed that it was opposite among females ( P < @number@ ) .
Data shows that hemokinin-1 was unstructured in aqueous environment ; anionic detergent SDS induces α-helix formation.
DATA SOURCE : Data are from the @number@ MCBS Access to Care file and include @number@ beneficiaries.
DATA SOURCE : Literature searches included electronic scientific databases and a manual search.
DATA SOURCES : A computerized systematic search was performed in Medline and Embase from @number@ to @number@
DATA SOURCES : A literature search was conducted through MEDLINE and EMBASE ( until @date@ ) .
DATA SOURCES AND STUDY SELECTION : Published prospective cohort studies were identified through a systematic search through @date@ without restrictions in several databases.
DATA SOURCES : Articles were identified through the electronic database search engines of CINAHL , Pub Med , and Academic Search Complete.
DATA SOURCES : A search of peer-reviewed articles in English from @number@ to @date@ was conducted using the EBSCO Health and Scopus databases.
DATA SOURCES : A search was conducted in PubMed , Ovid , CINAHL , and Cochrane Database of Systematic Reviews.
DATA SOURCES : A systematic search was conducted using multiple databases for relevant articles published from @number@ to @date@ .
DATA SOURCES : Comprehensive bibliographic searches in MEDLINE , the Cochrane Library , PEDro , and CINAHL databases were conducted ( @date@ ) .
DATA SOURCES : Databases Scopus , Psycho-info , CINAHL , PubMed , and ProQuest Cochrance were searched from @date@ to @date@ .
DATA SOURCES : Data research has focused on English-language articles in the Medline database , published from @number@ to @number@
DATA SOURCES : Eight electronic databases were searched from inception to @date@ , and extensive hand-searching was conducted.
Data Sources : Genomewide association studies ( GWAS ) published up to @date@ .
DATA SOURCES : Hospital records of TLC patients to track their hospital and emergency department visits before and after the TLC Partners enrollment.
DATA SOURCES : Literature for this concept analysis was retrieved from several databases , CINAHL , PubMed PsycINFO , for the years 1990-2012.
DATA SOURCES : Medicare enrollment records for years 2007-2011.
Data Sources : MEDLINE and EMBASE ( without language restrictions ) , from their inception to @date@ .
DATA SOURCES : MEDLINE , EMBASE and The Cochrane Library databases were searched from inception to @date@ .
Data Sources : MEDLINE , Embase , Cochrane Central Register of Controlled Trials , and Ageline databases from inception until @date@ .
Data Sources : MEDLINE , Scopus , CAB Abstracts , the Cochrane Central Register of Clinical Trials , and OpenGrey databases were searched.
DATA SOURCES : @number@ records were identified through searching of PubMed , Embase and Cochrane Library Database.
DATA SOURCES : @number@ records were identified through searching of PubMed , Embase and Cochrane Library Database.
DATA SOURCES : @number@ skeletal muscle and @number@ imprinted genes were subjected to g : Profiler ontology analysis.
DATA SOURCES : PubMed , Cochrane Database of Systematic Reviews , EMBASE , and CINAHL were searched in @date@ .
DATA SOURCES : PubMed , EMBASE , CINAHL and PsycINFO were searched up to @date@ .
DATA SOURCES : Pubmed , Embase , CINAHL , PsycInfo , Cochrane Library databases were searched.
DATA SOURCES : PubMed , EMBASE , Cochrane Database of Systematic Reviews , CINAHL and PsycINFO ( @date@ @number@ ) .
DATA SOURCES : PubMed , Google Scholar , ScienceDirect , and the Cochrane Database of Systematic Reviews from @date@ , to @date@ .
DATA SOURCES : PubMed literature searches , personal reference collection , and clinical experience.
DATA SOURCES : PubMed was used to search for relevant articles.
DATA SOURCES : Qualitative perspective of @number@ individuals randomized to a 6-week exercise program following hospital discharge post-thoracotomy for NSCLC.
DATA SOURCES : Selected research and clinical articles.
DATA SOURCES : the Cochrane Central Register of Controlled TRIALS , PubMed ( Medline ) , EMBASE , CINAHL , PEDro and Scholar-Google.
DATA SOURCES : The Cochrane Library , PubMed , EMBASE and Web of Science were searched.
DATA SOURCES : The data used in this review were mainly published in English from @number@ to present obtained from PubMed.
DATA SOURCES : The following databases were utilized : Cochrane , PubMed , Scopus , LILACS , SciELO , PAHO , MedCarib and WHOLIS.
DATA SOURCES : The included studies were retrieved from the databases MEDLINE and ISI Web of Knowledge.
DATA SOURCES : The recommendations were derived from the IOM report Delivering High-Quality Cancer Care : Charting a New Course for a System in Crisis.
DATA SOURCES : Thirteen electronic databases were searched from inception until @date@ in all languages.
DATA SOURCES : Three databases were searched : CIAHL , EMBASE , and MEDLINE.
DATA SOURCES : Trial , cohort , and nationally representative data sources.
DATA SOURCE : Studies published between @number@ and @number@ were identified from electronic databases and manual searching.
DATA SOURCES : Two previously published meta-analyses including an updated systematic search in PubMed and EMBASE.
Data sources were the Web of Science , Biological Abstracts , Medline , Pub Med , EBSCHost , Scirus and Google Scholar.
DATA SOURCES : We searched PubMed , EMBASE , PsychInfo , CINAHL , and the Cochrane Central Register of Controlled Trials.
Data stem from an online questionnaire completed by @number@ employees from different organizations in Germany ( all @number@ years or older ) .
Data such as these have helped to lay a foundation for the more effective management of postmenopausal osteoporosis.
Data suggest that BAT may be recruited throughout life.
Data suggest that long-chain n-3 polyunsaturated fatty acids ( PUFAs ) may enhance adaptations to resistance exercise in older women.
Data suggest that @number@ months of moderate-impact weight-bearing and multicomponent exercises reduces the potential risk factors for falls and related fractures in older women.
Data suggest that RAGE perpetuates the inflammatory signals initiated by AGEs via multiple mechanisms.
Data suggest that specifically designed cognitive interventions could impart therapeutic benefits to patients with AD that are associated with substantial biological changes within the brain.
Data suggest that the relation between kidney function and serum phosphorus should be reevaluated considering the possible confounding effect of age.
DATA SYNTHESIS : A random effects model meta-analysis determined whether orthogeriatric collaboration was associated with improved outcomes.
DATA SYNTHESIS : Data were narratively synthesized.
DATA SYNTHESIS : Eight studies met inclusion criteria.
Data synthesis followed a random-effects model.
DATA SYNTHESIS : Fourteen studies met inclusion criteria and were used to compute standardized mean differences using the inverse variance statistical method.
DATA SYNTHESIS : High-quality studies in this area are lacking.
DATA SYNTHESIS : Meta-analysis was performed for the comparison of exercise versus control with the inverse variance method under the random-effects models.
Data Synthesis : Mobility , disability , and nutrition were frequently assessed domains of frailty in both types of procedures.
DATA SYNTHESIS : Multimethod consensus-building approach by content leaders and content experts of the ONS Research Agenda Project Team .
DATA SYNTHESIS : Of the @number@ identified studies , seven RCTs including @number@ men were eligible for the meta-analysis.
DATA SYNTHESIS : Only skeletal muscle gene networks including imprinted genes were reported.
DATA SYNTHESIS : Poor preoperative functional status is associated with increased postoperative morbidity.
DATA SYNTHESIS : Qualitative research findings were synthesized using the JBI-QARI.
Data Synthesis supported by SAS @number@ ( SAS Institute , Inc.
DATA SYNTHESIS : The aging of the US population is creating a higher prevalence of systolic heart failure in the elderly.
DATA SYNTHESIS : The authors reviewed each of the recommendations to identify implications for oncology nurses.
DATA SYNTHESIS : The role of elevated low density lipoproteins for the risk of both vascular atherosclerosis and AS has been elucidated.
DATA SYNTHESIS : Three of the @number@ studies demonstrated a treatment interaction between ARMS2 and CFH genotypes and a differential response to supplements.
Data that emerged from large clinical trials showed an improved immunogenicity compared with that of standard vaccine.
Data underscore the need to consider anger feeling and both in-expression and out-expression of anger separately in order to understand anger experience in caregivers.
Data used are from the American Dental Association ( ADA ) and the American Dental Education Association ( ADEA ) .
Data used are from the @number@ to @number@ National Health Interview Survey on @number@ adults who completed the Adult Functioning and Disability Supplement.
Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative ( ADNI ) database ( adni.loni.usc.edu ) .
Data using fast speed TUG may be required among older adults with and without MCI for further understanding.
Data was also obtained from mouse PANC-1 tumor xenografts after administration of ( R , R' ) -MNF.
Data was analysed using an inductive and comparative approach.
Data was analysed using a thematic analysis.
Data was analyzed by ANOVAs with alpha set at @number@
Data was analyzed by classification tree and logistic regression analysis.
Data was analyzed thematically by means of coding and subsequent exploration of patterns.
Data was best fit by a model with both increased inhibitory and excitatory weightings in the older group.
Data was collected at baseline , and at three and six months thereafter.
Data was collected from the Southern Portugal Cancer Registry ( ROR-Sul ) database and completed with clinical chart information.
Data was collected in @number@ by the Health , Well-Being and Aging Study.
Data was collected on @number@ KA patients , ages 50-75 , residing in the Seattle metropolitan area.
Data was collected using semi-structured interviews , and analysis was done using an inductive approach.
Data was extracted about effectiveness , costs and factors that had a positive or negative influence on the outcome of CGA.
Data was obtained from The Irish Longitudinal Study on Ageing ( TILDA ) .
Data was processed statistically by \ "ANOVA \ ".
Data was then extracted from the selected articles and identified issues were analyzed and grouped into three major categories.
Data were abstracted from studies by two independent authors.
Data were acquired at three different times , corresponding to three assessments : initial , spontaneous , and after protein supplementation.
Data were aligned on biological ages [ years from peak height velocity ( PHV ) ] to control for maturity.
Data were also included for moderate reliability ( n = 20 and @number@ respectively ) .
Data were analysed according to CYP2C19 genotype.
Data were analysed according to techniques of coding and constant comparison.
Data were analysed through descriptive calculations , and answers to open-ended questions were coded using content analysis.
Data were analysed to determine annual means and percentage changes.
Data were analysed using a conditional logit model.
Data were analysed using a constant comparative approach and coded for thematic patterns and relationships from which overarching themes were constructed.
Data were analysed using a phenomenological approach.
Data were analysed using a qualitative content analysis.
Data were analysed using a thematic approach incorporating themes that had been identified in advance , and themes derived from the data.
Data were analysed using conventional discrete-time hazard and marginal structural models ( MSMs ) .
Data were analysed using Cox proportional hazard models , competing risk regressions and Laplace regressions with adjustment for potential confounders.
Data were analysed using linear regression analyses and adjusted for age , BMI , 25-hydroxyvitamin D , parathyroid hormone and vitamin K antagonist use.
Data were analysed using Mann-Whitney U-tests and regression analyses.
Data were analysed using methodological triangulation.
Data were analysed using mixed model with random sampling to account for both eyes from the same individual.
Data were analysed using multiple linear regression adjusting for age , gender and body size.
Data were analysed using multiple regression and path analyses.
Data were analysed using qualitative content analysis.
Data were analysed using Student's t , Chi-squared or ANOVA tests.
Data were analysed using the constant comparative method.
Data were analysed using the constant comparative method until data saturation occurred and a substantive theory was generated.
Data were analysed using thematic analysis.
Data were analysed with respect to both age and gender.
Data were analysed with thematic coding and constant comparison.
Data were analyzed according to the gender and according to the age ( < 70 or ≥70 years old ) .
Data were analyzed based on thematic content analysis using MAXQDA @number@ qualitative data analysis software.
Data were analyzed by ANOVA and Student-Newman-Keuls at alpha = @number@
Data were analyzed by descriptive statistics and partial correlation.
Data were analyzed by fitting univariate and bivariate twin models to estimate the genetic and environmental influences on these measures of physical function.
Data were analyzed by general linear modeling for repeated measures and Student-Newman-Keuls test for post hoc comparisons at α = @number@
Data were analyzed by Kruskal-Wallis and the Mann-Whitney U tests ( a = @number@ ) .
Data were analyzed by means of content analysis.
Data were analyzed by means of logistic and linear regression analyses.
Data were analyzed by one-way analysis of variance and by Student's t-test.
Data were analyzed by three-way analysis of variance and Tukey test ( α = 0.05 ) .
Data were analyzed by two-way analysis of variance ( ANOVA ) followed by Tukey's post hoc test ( p < @number@ ) .
Data were analyzed by two-way repeated measure ANOVA and Tukey's test ( α = 0.05 ) .
Data were analyzed by using multistate models that estimate probabilities of different outcomes.
Data were analyzed comparing older patients ( more than @number@ years-old ) with younger adults ( less than @number@ years-old ) .
Data were analyzed for potential association with injury occurrence and severity , with stratification by age.
Data were analyzed for the presence of third ( S3 ) and fourth ( S4 ) heart sounds and for systolic time intervals.
Data were analyzed from @date@ , to @date@ .
Data were analyzed from publicly available resting state scans for @number@ individuals between the ages of @number@ and @number@
Data were analyzed in a cross-sectional manner.
Data were analyzed respectively using paired t tests and grounded theory methodology.
Data were analyzed systematically and comparatively using a thematic approach to explore the depth of opinions and understandings of oral health and disability.
Data were analyzed to determine NUMT proportion and distribution on a genome-wide scale.
Data were analyzed using a modified grounded-theory approach.
Data were analyzed using analysis of covariance models with change scores.
Data were analyzed using analysis of variance.
Data were analyzed using a relaxed and a stringent statistical approach.
Data were analyzed using a sample of @number@ adults , aged @number@ years or older , from the 2006-2012 Health and Retirement Study.
Data were analyzed using both traditional approaches ( e.g. , intraclass correlation coefficients , Bland-Altman plots ) and the theory of generalizability.
Data were analyzed using constant comparative analysis.
Data were analyzed using continuous wavelet analysis to assess temporal Intensity distribution across eight frequency bands.
Data were analyzed using Cox proportional hazards models stratified according to age ( < 78 , ≥78 ) .
Data were analyzed using descriptive and inferential statistics.
Data were analyzed using descriptive , comparative analysis , and binary logistic regression.
Data were analyzed using descriptive statistics.
Data were analyzed using descriptive statistics and multivariable logistic regression.
Data were analyzed using descriptive statistics , parametric statistics , and content analysis.
Data were analyzed using fixed or random ( if data were heterogeneous ) effects meta-analysis using RevMan @number@
Data were analyzed using grounded theory and thematic analysis.
Data were analyzed using hermeneutic phenomenological analysis.
Data were analyzed using hierarchical linear models.
Data were analyzed using item analysis , factor analysis , criterion related validity , and internal consistency.
Data were analyzed using item-total correlations , Cronbach's alpha , confirmatory factor analysis , and analysis of variance.
Data were analyzed using joint Poisson regression models.
Data were analyzed using linear mixed models.
Data were analyzed using McCracken's 5-step process for long interviews.
Data were analyzed using multi-level multinomial logistic regression , adjusted for sociodemographic and health variables , and PA level.
Data were analyzed using multiple logistic models controlling for potential confounders.
Data were analyzed using multiple mediation modeling.
Data were analyzed using multivariate linear regression analyses.
Data were analyzed using nonparametric tests.
Data were analyzed using qualitative description and thematic analysis techniques.
Data were analyzed using regression analyses.
Data were analyzed using regression models for repeated measures.
Data were analyzed using repeated-measures analysis of variance and presented as means with @percent@ confidence intervals ( CIs ) .
Data were analyzed using repeated measures analysis of variance , with statistical significance set at the P ≤ @number@ confidence level.
Data were analyzed using SAS survey procedures.
Data were analyzed using SPSS software.
Data were analyzed using STATA software and thematic content analysis.
Data were analyzed using structural equation modeling.
Data were analyzed using the generalized estimating equation approach.
Data were analyzed using the principles of Grounded Theory.
Data were analyzed using three-way ANOVA and Dunnett-T3 post-hoc tests.
Data were analyzed using t tests , Pearson's correlation coefficients , and linear regression analysis , at a level of significance P < @number@
Data were analyzed using two-way repeated measures of analysis of variance ( ANOVA ) and a posthoc Bonferroni test ( p < 0.05 ) .
Data were analyzed via repeated-measures ANOVA and Pearson r correlations.
Data were analyzed with ANOVA followed by Tukey test ( p < 0.05 ) .
Data were analyzed with autoregressive cross-lagged panel analysis.
Data were analyzed with a Wilcoxon signed-rank test , statistical significance levels were set at p < @number@
Data were analyzed with flexible parametric survival models that adjusted for potential confounders.
Data were analyzed with logistic and mediation models controlling for potential confounders.
Data were analyzed with logistic regression models adjusting for age , education , anxiety , depression and hearing thresholds.
Data were analyzed with mixed-effects regression models.
Data were analyzed with multinomial logistic models controlling for potential confounders.
Data were analyzed with multiple general linear and logistic regression models.
Data were analyzed with multiple logistic models.
Data were analyzed with multivariate linear regression models.
Data were analyzed with one-way analysis of variance ( ANOVA ) , Dunnett's-T3 post hoc , and independent t-tests ( p < @number@ ) .
Data were analyzed with one-way ANCOVA with Delta scores and pre and post-training tests raw scores.
Data were analyzed with Statistica @number@ software.
Data were analyzed with the ANOVA / Tukey's test ( α = @number@ ) .
Data were analyzed with the use of Atlas.ti version @number@
Data were assessed and statistically analysed using logistic regression techniques.
Data were assessed for measures of latency to sleep onset , sleep duration , waking , and sleep staging during the night.
Data were available on @number@ participants ( @number@ women ; @number@ APOE ε4 carriers ; mean age , @number@ years ) .
Data were collated and analyzed using content analytical techniques.
Data were collected after the last treatment and at the 1-month follow-up visit.
Data were collected and analysed using a qualitative constructivist grounded theory approach.
Data were collected as part of a cross-sectional study of disability with @number@ members of a federally recognized tribe using in-person interviewer administered surveys.
Data were collected as part of a longitudinal study of growth and development.
Data were collected at admission , discharge , and @number@ months after admission.
Data were collected at baseline ; @number@ @number@ and @number@ months after intervention.
Data were collected at baseline , postintervention ( 6mo ) , and follow-up ( 9mo ) .
Data were collected at the baseline , after the last treatment and at 1-month follow-up visit.
Data were collected at three occasions separated by four-year intervals.
Data were collected at two time points separated by three years.
Data were collected before and after intervention.
Data were collected before and after the intervention and after @number@ months.
Data were collected before the 1st treatment and during the 1-month follow-up visit.
Data were collected between @date@ and @date@ .
Data were collected between @number@ and @number@
Data were collected by a digital questionnaire.
Data were collected by a mailed questionnaire and interviews.
Data were collected by a structured questionnaire and clinical measurements taken by trained and calibrated examiners.
Data were collected by Ellison & Palutzian Spiritual Well-Being Index and Short Form Quality of Life ( SF-36 ) .
Data were collected by mail beginning in @number@
Data were collected by self-report using an on-line survey.
Data were collected by structured home interviews.
Data were collected by the Department of Forensic Medicine at the University Hospital Giessen and Marburg during @number@ and @number@
Data were collected during interviews by occupational physicians in @number@ @number@ and @number@
Data were collected during the national influenza vaccination campaign in Rio de Janeiro , Brazil , in @number@
Data were collected from administrative staff.
Data were collected from a random sample of EA cases ( n = @number@ ) at a protective service program in New York City.
Data were collected from community samples.
Data were collected from company documents , by means of a direct-question interview focusing on socio professional informations and through measurements.
Data were collected from @date@ , through @date@ .
Data were collected from @date@ to @date@ .
Data were collected from @date@ to @date@ .
Data were collected from @date@ to @date@ in the rehabilitation center and the living environment of the participants after discharge.
Data were collected from elderly people living in the community who were certified as eligible for care level 2-5 under Japanese long-term care insurance.
Data were collected from electronic medical records and an institutional database of cardiovascular implantable electronic devices.
Data were collected from home-based personal interviews using a structured questionnaire.
Data were collected from @number@ dyads ( @percent@ ) at @number@ months and @number@ ( @percent@ ) at @number@ months.
Data were collected from @number@ grandmothers and their @number@ to 27-month-old infant grandchildren.
Data were collected from @number@ nursing homes in Israel between @date@ and @date@ .
Data were collected from @number@ participants residing in @number@ LTC homes in four Canadian provinces by trained researchers.
Data were collected from @number@ seniors , @number@ teachers , and @number@ coordinators.
Data were collected from the Korea National Health and Nutrition Examination Surveys ( 2010-2013 ) .
Data were collected in a @number@ min eyes-open / eyes-closed resting state paradigm.
Data were collected in household interviews.
Data were collected in individual interviews using a semi-structured guide and analyzed by content analysis.
Data were collected in @number@ and analyzed in 2013-14.
Data were collected in @number@ and @number@
Data were collected in @number@ by personal home-based interviews , using structured questionnaires.
Data were collected of patient backgrounds , adverse events and dose intensity within the first two cycles and overall survival time.
Data were collected on activities of daily living ( ADL ) , instrumental ADL ( IADL ) , and medical history and laboratory.
Data were collected on hemoglobin along with socioeconomic and sociodemographic factors of the households.
Data were collected online.
Data were collected on @number@ occasions across a 10-year period.
Data were collected on self-reported hypertension , measured blood pressure , medications , as well as sociodemographic and other health-related factors.
Data were collected over @number@ months pre- and post-introduction of a pharmacist to a physician-led ward round.
Data were collected prospectively in a single surgery university center ( Paris , France ) .
Data were collected regarding functional status , glycemic control , antidiabetic treatments , comorbidities , and biochemical and clinical measurements.
Data were collected through 60-90 min , in-depth , semi-structured interviews.
Data were collected through a structured interview , physical examination , and magnetic resonance imaging.
Data were collected through a validated questionnaire.
Data were collected through group and individual in-depth interviews and participant observations which involved @number@ individuals , aged 52-76.
Data were collected through interview , clinical examination , psychological testing , and laboratory tests.
Data were collected through interviews and analysed with interpretive content analysis.
Data were collected through interviews with @number@ home care staff of a large home care organization in Ontario , Canada.
Data were collected through semistructured , individual interviews.
Data were collected through semi-structured interviews and submitted to descriptive and thematic analysis.
Data were collected through telephone surveys of @number@ English-speaking immigrants in Atlanta , GA.
Data were collected using a socio-demographic and clinical questionnaire , the Rikli and Jones Senior Fitness Test , handgrip dynamometry and bioelectric impedance.
Data were collected using audiotapes , which were then transcribed.
Data were collected using phone interviews @number@ @number@ and @number@ months after surgery.
Data were collected using questionnaires and clinical assessments.
Data were collected using the Fall Risk Score , which was analyzed using SPSS @number@
Data were collected using the interRAI Acute Care assessment tool.
Data were collected via surveys , telephone , and personal-interviews in four major Australian cities.
Data were combined using a random-effect model.
Data were compared between individuals with absent or punctuate ( n = @number@ ) and early confluent or confluent ( n = @number@ ) WMH.
Data were compared between @number@ and @number@
Data were compared between steps for each day and between different days.
Data were compared on the basis of lesion characteristics , using WEKA software for statistics and modeling.
Data were compared with current United Kingdom ( UK ) dietary reference value ( DRV ) for FS via a t test.
Data were compared with @number@ younger dysphagic patients ( @number@ ± @number@ years ) .
Data were compared with previously published data from young participants with normal hearing.
Data were compared with that from subjects who had not received colonoscopies.
Data were compiled from the @number@ statistical divisions in mainland Australia plus the island of Tasmania ( n = 53 observations ) .
Data were conducted by notifications cards of After Vaccinations Adverse Effects located at the Reference Center of Special Immunobiological from January to @date@ .
Data were derived from Beijing longitudinal study of aging , a community-based cohort study hosted by Xuanwu hospital.
Data were derived from four focus groups conducted in the greater Los Angeles area.
Data were derived from group and individual interviews with home-dwelling retirees in the Faroe Islands.
Data were derived from the nationally representative Medical Expenditure Panel Survey.
Data were divided into quintiles to create cutoffs for physical performance rankings that can be used when reporting results to the general public.
Data were drawn from a sample of @number@ community-dwelling adults , aged @number@ and older , living in the Canadian province of Manitoba in @number@
Data were drawn from Statistics Canada's Canadian Community Health Survey , Cycle @number@
Data were drawn from the @number@ California Health Interview Survey ( CHIS ) .
Data were drawn from the two first waves of the Survey of Health , Ageing and Retirement in Europe.
Data were drawn from two waves , which were three years apart.
Data were drawn from Waves @number@ and @number@ which were @number@ years apart.
Data were entered and analyzed using Microsoft Excel.
Data were evaluated by 3-way repeated-measures ANOVA and the Tukey HSD test ( α = @number@ ) .
Data were evaluated using corresponding analysis , contingency analysis , logistic regression and a multinomial exploded logit model.
Data were examined using the results from the European ZINCAGE study on @number@ community-dwelling Italians aged @number@ years and over.
Data were extracted and reasons for choosing emergency and urgent care were identified and mapped.
Data were extracted and results were synthesised using forest plots and narrative summary.
Data were extracted for each study participant and placed onto a timeline for month of observation.
Data were extracted from a prospective protocol of bacteraemia cases recorded.
Data were extracted from @number@ participants enrolled in the Mayo Clinic Study of Aging.
Data were extracted from the electronic health records and reviewed.
Data were extracted in a standardized manner and assessed through the Strengthening the Reporting of Observational Studies in Epidemiology ( STROBE ) initiative.
Data were extracted on studies that included older adults in care homes.
Data were extracted using a pre-defined list.
Data were extracted using standardized extraction forms and analyzed using thematic analysis.
Data were from the 2005-2006 and 2010-2011 waves of the U.S. National Social Life , Health , and Aging Project.
Data were from the @number@ NJ FamilyCare Family Health Survey ( n = @number@ families ) .
Data were from the @number@ survey of the Korean Longitudinal Study of Aging ( KLoSA ) .
Data were from the Woodlawn Study , a prospective study of children and their families from an African American community in Chicago.
Data were gathered by in-depth interviews.
Data were gathered using chart review and patient follow-up.
Data were gathered using individual semi-structured interviews , audio recorded and transcribed verbatim.
Data were gathered via 3D volume-rendered images.
Data were gathered via focus groups and questionnaires.
Data were gathered via structured interviews in participants ' home.
Data were harmonised , analysed separately employing Cox proportional hazard regression models , and combined by meta-analysis.
Data were independently extracted and assessed by one reviewer and checked by a second.
Data were less supportive of a physiological correlate of ratings of restoration from sleep.
Data were limited on the impact of procedure complexity , endovascular compared to open surgery or type of anaesthetic.
Data were manually curated from @number@ publications.
Data were missing from @percent@ to @percent@ within the individual questions.
Data were not available for RPA class from this series.
Data were obtained by @number@ self-administered questionnaires and the exposure was obtained by linkage to the Prescription Database of Norway.
Data were obtained from a large longitudinal cohort study of initially nondemented individuals recruited via primary care chart registries and followed at 18-month intervals.
Data were obtained from a @number@ telephone survey using the Random Digit Dialing method and including @number@ individuals ( @percent@ participation rate ) .
Data were obtained from a pharmacy provider for @number@ LTC homes in @number@ and @number@ homes in @number@
Data were obtained from @number@ adult ( 30-85 ) participants in the United States norming study for the NIH Toolbox.
Data were obtained from @number@ HIV-infected adults enrolled in a prevalence study of autonomic dysfunction from 2011-2012.
Data were obtained from @number@ LGBT older adults.
Data were obtained from personal references , home pages viewing and direct e-mail inquiries to relevant institutes.
Data were obtained from Research on Older Adults with HIV ( n = @number@ ) .
Data were obtained from semi-structured interviews and analyzed using a grounded theory approach.
Data were obtained from the Alzheimer's Disease Neuroimaging Initiative database.
Data were obtained from the National Alzheimer's Coordinating Center on autopsied subjects ( N = @number@ ) who died between @number@ and @number@
Data were obtained from the National Electronic Injury Surveillance System-All Injury Programme ( NEISS-AIP ) for the years @number@ through @number@
Data were pooled by fixed or random effect modeling , according to the presence of heterogeneity.
Data were prepared using Tract-Based Spatial Statistics , and a priori regions of interest ( ROIs ) were extracted from T1-based WM parcellations.
Data were presented by cross-tabulation and logistic regression to investigate relationships among race / ethnicity , gender , and age groups.
Data were put into the personal computer.
Data were randomly divided for scale development ( n = @number@ ) and cross-validation ( n = @number@ ) .
Data were recorded and entered into Excel spreadsheets for coding and cleaning and transferred to SPSS @date@ @number@ for analyses.
Data were recorded prior to surgery , 6weeks and 6months later.
Data were recorded while @number@ young and @number@ older adults completed stair descent and ascent trials over a four-step instrumented staircase.
Data were reported by median and range or incidence.
Data were retrieved from the Cancer Registry of Norway.
Data were retrieved from the patients ' electronic medical records.
Data were retrospectively collected from yearly respiratory symptom questionnaires and spirometry examinations conducted from @number@ to @number@
Data were statistically analysed by SPSS @number@ programme and chi-square tests.
Data were statistically analyzed and figures and tables were produced relating PNIF to height , sex and age.
Data were stratified by criminal behavior type and diagnostic groups.
Data were subjected to analysis of variance and Fisher's test ( α = @number@ ) .
Data were subjected to analysis of variance and Student t test procedures to determine sex and age differences.
Data were subjected to a thematic analysis.
Data were subjected to a thematic content analysis.
Data were summarised using meta-analysis and age , segmentation technique and study type were tested as potential moderators using meta-regression.
Data were summarized and analysed with age-specific centiles and CIs calculated.
Data were summarized by using random-effects in the meta-analysis.
Data were thematically analysed.
Data were thematically coded and synthesised to identify underlying rationales and challenges encountered when involving professionals with ethnic minority backgrounds in interventions for ethnic minorities.
Data were therefore combined for further analysis to explore influences on dietary intake.
Data were transcribed and analyzed based on emergent themes.
Data were transcribed verbatim and analysed using systematic text condensation.
Data were used from @number@ men and women aged ≥65years of the Longitudinal Aging Study Amsterdam.
Data were used from @number@ participants in the Vietnam Era Twin Study of Aging.
Data were used to calculate two derived variables ; days to treatment ( DTT ) and days on treatment ( DOT ) .
Data were weighed according to gender and age of the Dutch population.
Data will also be used to identify mechanisms underlying frailty in this specific population.
Data will be abstracted , and study quality / risk of bias will be appraised by two reviewers independently.
Data will be analysed on an intention-to-treat basis using a linear mixed model for repeated measures.
Data will be analyzed using mixed effect models with the cluster treated as a random effect.
Data will be collected at baseline , @number@ and @number@ months.
Data will be collected at baseline , @number@ @number@ and @number@ months.
Data will be collected over four time points ; at baseline , immediately post-intervention , 3-months and 6-months follow-up.
Data will be extracted using a predefined pro forma following best practice.
Data will be synthesized using an NMA to allow for multiple comparisons using direct ( head-to-head ) as well as indirect evidence.
DAT binding was quantified using a simplified reference tissue model , and the cerebellum was used as reference region.
@date@ ) .
@date@ also plays a crucial role in reprogramming of somatic cells into induced pluripotent stem ( iPS ) cells.
@date@ binding to the @number@ to @number@ SNP region therefore remains a candidate interaction involved in lactase persistence.
@date@ is a master regulator of self-renewal of undifferentiated embryonic stem cells.
Date of enrolment of the first participant was @date@ .
@date@ of females were under @number@ years of age , and @date@ were over @number@ years of age.
Date registered 16 ( th ) @date@ .
Date Registered : @date@ .
Dates and proximate causes of death were logged for @number@ participants.
Dates of birth and death of the cyclists were obtained on @date@ .
@date@ stabilization by cobalt and nickel was mediated largely through reactive oxygen species ( ROS ) as co-treatment with ascorbic acid abolished @date@ increase.
Dating takes a harsher toll on parent-daughter compared to parent-son relationships.
DA toxicity is mediated by ROS production ( mainly anion superoxide ) that elicits a block in the formation of autophagosomes.
DATS also activated caspase-8 and @number@ the respective initiator caspases of the extrinsic and the intrinsic apoptotic pathways.
Daughters ' commitment deepens as mothers physically decline , and mothers remain engaged , emotional partners.
Daughters grow more emotionally committed to mothers ' over the care trajectory , despite increasing demands.
Dawdle , an Activin ligand , is bound and repressed by dFOXO when reduced insulin / IGF extends lifespan.
DAWN also recorded the disposition ( i.e. , outcome ) of the visit.
Day-case admissions and those moribund on admission were excluded.
Daylight PDT , using ambient visible light has been reported as safe , time- and cost-efficient , and more comfortable than with other light sources.
Day @number@ serum paracetamol concentrations were highest in older frail participants ( P < 0·005 ) .
Day @number@ TSH was found to be influenced by GFR ( group II ) .
Days off showed reduced sleepiness ( @number@ units ) , while being sick listed was associated with an increased sleepiness ( @number@ units ) .
Daytime sleepiness and DMN connectivity were not related to sex , brain structure , or body mass index.
Daytime tiredness and sleep duration were not associated with dementia in adjusted analysis.
DBC1 absence leads to an increase in PEPCK mRNA and protein expression.
DBC1 regulates the levels of Rev-erbα , and manipulation of Rev-erbα activity or levels prevents the effect of DBC1 on PEPCK.
DBC-A total scores were higher in the consecutive age groups , with the most behavioral problems in the oldest age groups.
Db / db mice were orally administered the leaf extract ( @number@ mg / kg / day ) for @number@ weeks.
DB got significantly lower with advancing age until @number@ years , and then plateaued.
Dbl is the prototype of a large family of GDP-GTP exchange factors for small GTPases of the Rho family.
DBS offers many advantages as a sample format including easy sample collection and cheap sample shipment.
DC and shrinkage-strain were maximum at the sequence : CQ < DEPT < DMPT≤CEMA≈DABE < DMAEMA.
DCD and GCD were also different between groups @number@ and @number@ ( P < @number@ P < @number@ ) .
DC function may be modulated by probiotics , which confer health benefits in immunocompromised individuals , such as the elderly.
D. chrysotoxum Lindl is widely known for medicinal values in traditional Chinese medicine as it possesses anti-inflammatory , anti-hyperglycemic induction , antitumor and antioxidant properties.
DCI was diagnosed from CT.
DC missed @percent@ of the SGA-B and @percent@ of SGA-C patients.
DCM was implemented using up to five cortical nodes.
DC patient-derived mutations in TCAB1 impair folding by TRiC , disrupting telomerase function and leading to severe disease.
DC patients also have a poor tolerance to chemo / radiotherapy and bone marrow transplantation.
DC-potential of the brain was performed in @number@ women 55-74 years old living in the circumpolar region.
DD affects between @percent@ and @percent@ of people of European descent and is the most common inherited disease of connective tissue.
DDE also reduced basal lipolysis in mature hsc adipocytes.
D-dimer and factor VIII were not associated with AIDS or non-AIDS death at @number@ or @number@ years.
D-dimer levels did not differ significantly between body mass index / HIV status groups.
DD rate showed a modest but significant decrease with age , suggesting a reduction in overall impulsivity from middle to late adolescence.
DDR with checkpoint activation was indicated by histone H2AX and Chk2 protein phosphorylation , and by increased p53 protein levels.
DDX39 is also found in association with catalytically competent telomerase in cell lysates through an interaction with hTERT but has no effect on telomerase activity.
Dealing with a cohort that has different biological and medical demands requires pharmacists to pay particular attention to details when treating this subset of individuals.
Dealing with attrited teeth and restoration of the lost tissue are clinically challenging.
Deamidated species included ankyrin , band @number@ band @number@ and the integral membrane protein band @number@
Deamidation at this site increased again in the eighth decade of life.
Deamidation of glutamine ( Q ) and asparagine ( N ) has been recognized as a marker of degradation and aging in ancient proteins.
Deamidation was mimicked by site directed mutagenesis ; thus , three mutants of HsTIM ( N15D , N71D and N15D / N71D ) were characterized.
Death across a 20-year follow-up period was confirmed primarily by death certificate.
Death certificates under-report influenza.
Death occurred in @percent@ ( n = 22 ) of the participants within the @number@ month follow up period.
Death occurred predominantly in very elderly patients undergoing nonelective PCI.
Death occurs as a result of complications of cardiac or cerebrovascular disease ( heart attack or stroke ) generally between ages @number@ and @number@ years.
Death of a critical number of ECM-maintaining mutant protein-expressing retinal cells contributes to that break point in the degenerative process.
Death rates and mean lifespan are basic life table functions typically used to analyze to what extent the forecasts deviate from their realized values.
Deaths due to stroke and myocardial infarction at the end of the follow up are considered the outcome.
Deaths from dementia increased by @percent@ , with an increase in deaths from neurodegenerative disease ( @percent@ ) and cancer ( @percent@ ) .
Deaths to @date@ were ascertained by data linkage.
Deaths were ascertained by biennial home visits and linkage with vital statistics registries.
Deaths were ascertained prospectively by flagging from the General Registrar's Office , Scotland.
Deaths were confirmed with death certificates ; cause of death was adjudicated by review of certificates and records.
Deaths were followed until the end of @date@ for @number@ years with complete ascertainment.
Deaths were identified in the National Death Registry ( @number@ deaths ) .
Deaths were recorded during a median follow-up of @number@ years.
Deaths were registered until the 31st of @date@ .
Death was ascertained by continuous verification of death certificates.
Death was predicted by two independent factors : an older age at onset and a high annualized relapse rate.
Debridement is an important process to decrease risk of infection and promote healing.
Debris scores were higher ( @percent@ increase ) on the upper tubes when compared with the lower ones , with no statistical difference.
Debts , ability to reduce work hours , and firm unionization also influenced retirement plans.
Decades of carriage studies in children have demonstrated that microbe-microbe competition and collusion occurs in the URT.
Decades of intensive research have identified a range of molecular and biochemical pathways contributing to aging.
Decedent data was submitted to the National Death Index for matching with underlying causes of death on state death certificates.
Decedents were men and women aged > 50 years who either had normal cognitive function or Alzheimer's disease.
Decellularized extracellular matrix ( dECM ) has recently emerged as a promising substrate for the improved expansion of MSCs.
Decellularized organs provide the ideal transplantable scaffold with all the necessary microstructure and extracellular cues for cell attachment , differentiation , vascularization , and function.
Deciduous mandibular canine and molar roots were staged into levels of resorption ( one quarter , one half and three quarters ) .
Deciphering the contribution of genetic instability in somatic cells is critical to our understanding of many human disorders.
Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance.
Deciphering the mechanisms underlying this pleiotropy might provide important information on the biological underpinnings of these disabling conditions.
Decision for surgical management of pHPT should be done regardless of age.
Decision-making for these particularly vulnerable patients is a common and vexing concern for healthcare providers and hospital ethics committees.
Decision-making performance in mild DAT might be improved by helping the patients at a predecisional stage to gather sufficient information and evaluate options more accurately.
Decision-making strategies changed after childhood from erratic behavior to more consistent strategies that promoted expected value of deck choices.
Decisions on age appropriateness were made using a Delphi process.
Decisions on appropriate therapy should be made considering clinical presentation , underlying pathophysiology , and stage of disease.
Decisions regarding endovascular treatment of elderly patients should be individualized until randomized controlled trials are available.
Decision tree and Monte Carlo analyses tested robustness of the economic models.
Decision tree models were used to identify optimal cut-off points for clinical and physiological predictors of aVSP and DCI.
Declarative memory evaluation is an essential step in the clinical and neuropsychological assessment of a variety of neurological disorders.
Decline in both telomere length and physical fitness over the life course may contribute to increased risk of several chronic diseases.
Decline in cerebrovascular health complicates brain aging , and development of cerebral microbleeds ( CMBs ) is one of its prominent indicators.
Decline in episodic memory is one of the most prominent cognitive deficits seen in late adulthood.
Decline in executive functioning ( EF ) is a hallmark of cognitive aging.
Decline in executive function was associated with greater risk of reported and confirmed elder self-neglect.
Decline in FEV1 / FVC ratio is associated with underfilling of the left heart and low cardiac output.
Decline in FVC was associated with diastolic dysfunction ( odds ratio , @number@ @percent@ confidence interval , @number@.37-8.36 ; P = @number@ ) .
Decline in FVC with preserved FEV1 / FVC ratio is associated with left ventricular hypertrophy and diastolic dysfunction.
Decline in global cognitive function was associated with risk of greater self-neglect severity.
Decline in information processing speed explained a moderate proportion of the SRTn decline.
Decline in motor function precedes decline in performance on processing speed tasks , even though the motor function tasks were not timed.
Decline in muscle thickness from age 40-79 was greater for gastrocnemius than for soleus.
Decline in sustained oxygen therapy use after @date@ be related to reimbursement policy change.
Decline in taste function also occurs during aging.
Decline of cognition and increasing risk of neurodegenerative diseases are major problems associated with aging in humans.
Decline of cognitive function is a part of aging.
Decline or no decline on the Cognitive Performance Scale was the dependent variable.
Decliners had more brain atrophy and higher rates of conversion to dementia.
Declines in gait speed over @number@ years were similar for all groups.
Declines in muscular strength resulting from reduced neural activity may influence the reduction in aerobic capacity in older men.
Declines in remembering and health were also coupled ; moreover , changes in both were coupled with change in lifestyle control beliefs.
Declines in skeletal muscle mass and strength are major contributors to increased mortality , morbidity and reduced quality of life in older people.
Declines in the control of attention and working memory are often considered a core feature of cognitive aging.
Decline was explained primarily by cognitive status at the time of admission , notably present orientation.
Decline was greatest in the AD cohort and in those who progressed from mild cognitive impairment to AD.
Decline was not predicted by sex , baseline MMSE score , or presence of specific DLB core features.
Declining cholesterol levels from midlife to late life may better predict AD risk than levels obtained at one timepoint prior to dementia onset.
Declining CR fitness over @number@ years was associated with brain atrophy in AD , especially in the parahippocampus.
Declining functionality of the neurotrophin ligand-receptor system is considered one of the hallmarks of neuropathological aging.
Declining physical function is a major health problem for older adults as it is associated with multiple comorbidities and mortality.
Declining testicular function and hypothalamic dysregulation appear to be the mechanisms explaining the fall in testosterone levels with age.
Decolonization techniques may decrease subsequent MRSA SSI in colonized patients.
Decomposition-enhanced spike-triggered averaging was used to collect surface and intramuscular electromyography signals during dorsiflexion at ∼25% of maximum voluntary isometric contraction.
Deconditioning effects are rapidly seen in the regulation of heart rate to compensate for physical modifications in blood volume and cardiac function.
Decorin is the predominant proteoglycan in human dermis.
Decorin was localized in dermal extracellular matrix with GAG bound to type I collagen fibrils.
Decorin was predominantly produced by dermal fibroblasts.
Decreased activities and social support increased perceptions of stress , which then increased depressive symptoms during the 8-year follow-up study.
Decreased adiponectin and increased tumour necrosis factor-α in PVAT play a pathological role for neointimal hyperplasia after endovascular injury.
Decreased alertness should not be dismissed as \ "old age \ ".
Decreased arterial compliance is one of the earliest detectable manifestations of adverse structural and functional changes within the vessel wall.
Decreased autophagic function in particular may promote the initial development of hepatic steatosis and progression of steatosis to liver injury.
Decreased AVPD suggests that tricuspid annular excursion , a marker of RV function , is less valid in these patients.
Decreased baseline cerebral perfusion also emerged as a strong predictor of poorer 12-month attention / executive function.
Decreased BDNF levels may constitute a lack of trophic support and contribute to cognitive impairment in AD.
Decreased birth rates and longer lifespans indicate that the global population is aging , although rates of aging differ between countries [ @number@ ] .
Decreased brain metabolism with aging in males and females is similar to findings reported in previous literatures.
Decreased cerebral blood flow and blood-brain barrier disruption are features of Alzheimer's disease ( AD ) .
Decreased cerebral protein and activity levels of glutamine synthetase ( GS ) have been reported for Alzheimer's disease ( AD ) patients.
Decreased CFTR expression in sperm was also found to be associated with lowered sperm quality in aging mice.
Decreased cognitive skills concurrent with reduced perceptual acuity are thought to contribute to the difficulty older adults experience understanding speech in noise.
Decreased CpG island methylation and increased levels of active histone marks at genomic regions encoding miRNAs were observed after 5-AzaC treatment.
Decreased depressive symptomatology was associated with high overall , affectionate , and positive interaction support , and decreased chronic pain with affectionate support.
Decreased exercise capacity is a cardinal symptom of HFpEF.
Decreased expression of VASH2 in ovarian cancer cells significantly repressed the expression of TGF-β type I receptor , namely activin receptor-like kinase @number@
Decreased fecundity and an increased risk for disturbed pregnancies occur with advancing paternal age.
Decreased heart rate variability and depression are both independent risk factors for cardiac mortality in clinical and non-clinical samples.
Decreased HRV has predictive value for mortality in general population samples and patients with myocardial infarction and used as an indicator of altered autonomic function.
Decreased immune responsiveness associated with aging is generally termed \ "immunosenescence \ ".
Decreased interest in sex and anxiety before sex were associated with subthreshold depression.
Decreased KCO might be useful , particularly among women , for identifying smokers at high risk for aging-related systemic manifestations and telomere shortening.
Decreased levels of acetylated-tubulin and increased levels of phosphorylated-tau at @number@ @number@ and @number@ epitopes were also observed in the hippocampus of the smoking rats.
Decreased libido or reduced frequency and quality of erections , fatigue , irritability , infertility or a diminished feeling of wellbeing may be presenting complaints.
Decreased longevity coupled with an age-dependent loss of climbing ability was observed.
Decreased LRP1 expression also attenuated AMPA-evoked calcium influx and reduced GluA1-regulated neurite outgrowth and filopodia density.
Decreased mean diffusivity on attenuation coefficient maps might be associated with astrocytic gliosis.
Decreased mean diffusivity with age was observed in GM and WM irrespective of gender.
Decreased modulation in response to cognitive challenge was associated with reduced task accuracy as well as poorer name-face associative memory performance.
Decreased muscle strength and BMI , but not neuropathy , were associated with outcome of functional capacity tests in multiple regression analysis.
Decreased NAD + levels with age reduce SIRT1 function and reduce the mitochondrial unfolded protein response , which can be overcome by NR supplementation.
Decreased neurogenesis in the hippocampus has been recognized as one of the mechanisms of age-related brain dysfunction.
Decreased neuronal activity , increased Aβ levels , and inflammation further damage myelin in patients with AD.
Decreased neuronal activity is an essential characteristic of AD , and a substantial decrease of cerebral glucose metabolism may even precede cognitive impairments.
Decreased odds of titer elevation were seen in patients with early-onset MG than in those with late-onset MG.
Decreased p-AKT activity in turn promotes cellular senescence through upregulation of p53 and p27 expression.
Decreased p-AKT activity results from repression of integrin-linked kinase ( ILK ) and protein kinase-1 ( PDPK1 ) expression.
Decreased Par4 expression increases the amount of CEBPB , which binds to the FAK promoter and enhances FAK transcription.
Decreased proteins , mostly of extracellular origin , included adiponectin , lumican , plasminogen and leukemia inhibitory factor receptor.
Decreased proteolytic clearance of soluble amyloid β ( Aβ ) in microglia affects Aβ accumulation on Alzheimer's disease progression.
Decreased R2 with age may reflect physiological tissue degeneration , whereas increased R2 and R2 ' with age most likely denote physiological iron accumulation.
Decreased sensitivity and absence of regular foot checks can contribute to use of inadequate footwear.
Decreased time available in responding to perturbations might result in a greater number of falls.
Decreased urinary Klotho protein level has been identified as one of the earliest biomarkers of CKD progression.
Decreased vasopressin and oxytocin immunoreactivity in hypothalamic neurons was also observed.
Decreased vesicular uptake of dopamine and decreased DOPAL detoxification by aldehyde dehydrogenase ( ALDH ) determine this buildup.
Decreased visual acuity is probably the most common effect of age-related anatomical and neurological changes in the eyes and the visual pathway.
Decreased αDG and βDG protein levels were verified in the PC and HGPIN groups.
Decrease in ATP synthesis is correlated with accumulation of calcium ions in cells , dysfunction of mitochondria , and increasing apoptotic activity.
Decrease in cortical thickness is not reflective of the cognitive performance at the early stage of AD.
Decrease in HbA1c from baseline to Months @number@ and @number@ was non-inferior in geriatric compared with non-geriatric patients.
Decrease in homocysteine with VSL # 3 was clinically relevant. suggesting protective potentials for aging-associated conditions , e.g. cardiovascular or neurological diseases.
Decrease in level of bioenergetics below certain critical level deprives a cell the ability to pass the restriction point of G1-phase of proliferative cycle.
Decrease in serum Zn and Se levels , low BMD , and increase in CZr and oxidative stress were observed in physically disabled patients.
Decrease of mortality cost that accounted for a large part of the COI ( @percent@ in @number@ ) was the major contributing factor.
Decrease or loss of asymmetric cell division can be associated with reduced differentiation common during aging or impaired remyelination as seen in demyelinating diseases.
Decreases in circulating melatonin levels have been reported in patients with diseases that become more serious with advancing age.
Decreases in cortical thicknesses in regions that comprise the language network likely reflect maturation toward adult-like cortical organization and processing efficiency.
Decreases in estrogen levels contribute not only to early postmenopausal bone loss but also to bone loss with aging.
Decreases in FA correlated well with neuropsychological dysfunction.
Decreases in levels of sex hormones occur with aging.
Decreases in life expectancy without type @number@ diabetes were more pronounced in women than in men.
Decreases in local efficiency during the working memory task were associated with better working memory performance in both age cohorts.
Decreases in motor and mental capabilities , however , frequently make daily activities more difficult for them.
Decreases in oral mucosal defence can be a predisposing factor for the development of oral mucosal diseases in the elderly.
Decreases in serum OC and ucOC were more obvious in Group M than in Group A ( P < 0.001 ) .
Decreases in tissue contrast were associated with hippocampal volume , however , the regional patterns of these associations differed for demented and nondemented individuals.
Decreases were also seen in asthma hospitalizations and men's age-adjusted AMI hospitalization and SCD rates.
Decreasing amounts of extracted collagenase digestible collagen correspond with increasing AGE autofluorescence.
Decreasing Aβ levels through targeting APP processing is a very promising direction in clinical trials for AD.
Decreasing calorie intake has been known for a long time to have a beneficial effect on longevity and health.
Decreasing contact angles are the direct consequence.
Decreasing frailty score independently predicted a day @number@ ALT above the ULN ( P < 0·05 ) .
Decreasing menarche age was also observed for Chinese girls.
Decreasing oxidative stress and increasing antioxidant defense has been hypothesized as one mechanism by which caloric restriction ( CR ) increases longevity in animals.
Decreasing patterns were seen with age ; with lower risks in the ID group for the oldest age groups.
Decreasing risk of progression with longer time already spent in a stage was also previously found for post-transplant progression.
Decreasing telomere length in the cells of an immune system can indicate immune aging in immune-mediated and chronic inflammatory diseases.
Decrements in physical health have a statistically significant effect on nutrient intake.
Decrements in physical health were associated with decreasing intake of many fat-soluble and water-soluble vitamins , major minerals , trace minerals and electrolytes.
Decrements in vasodilation and sweating are well documented with age , yet limited data are available concerning the regional relation between these responses.
Decrements in working memory and processing speed were associated with IADL limitations ( p < @number@ ) .
Decrements were related to an increase in hot flushes ( P = 0·016 ) but not haemoglobin decrease ( P = 0·46 ) .
DED following ocular surgery also showed sexually different patterns.
Dedicated studies are needed to evaluate the impact of social interventions for disabled elderly on ER access rates.
Dedicated studies show that the true prevalence is 30-100% , depending on cohort.
Dedifferentiated liposarcoma , one of the most frequent types of malignant adipose tumors , has a high potential of recurrence and metastastic evolution.
De-differentiated VSMC contribute to pathologies including atherosclerosis and intimal hyperplasia.
Dedifferentiation was induced by successive passages of human articular chondrocytes , whereas their redifferentiation was performed by three-dimensional culture in alginate.
DEDIPAC was launched in late @number@ and delivered its final report in late @number@
DED was defined as the presence of frequent ocular dryness or a previous diagnosis by an ophthalmologist.
Deep brain stimulation is a neurosurgical therapy for patients with advanced movement disorders ( e.g. , Parkinson's disease ) .
Deep coma in nordiazepam overdose whatever the dose and deep coma in overdose with oxazepam involving TI less than @number@ result from unrecognized drug-drug interaction.
Deeper insights into biological mechanisms mediating gene action are critical for understanding the genetic regulation of a healthy lifespan and for personalizing medical care.
Deeper knowledge and more research is needed in order to fully understand the contexts in which dementia is constructed under the law.
Deeper solar elastosis was significantly associated with older age and female sex.
Deeper wrinkles caused elevated loads in the SC consistently for all outcome measures and independently of the age factor.
Deep fat compartments and facial bones lose volume during the natural aging process.
Deep fat , underlying a facial rhytide , was identified underneath the nasolabial crease and the labiomental sulcus.
Deep glabellar rhytides , however , are difficult to correct with filler.
Deep sequencing of DNA from the proband's blood revealed @percent@ c.1968 + 2T > C mutation , and @percent@ c.1968 + 2T > A mutation.
Deep white matter hyperintensity ( DWMH ) and periventricular ( PV ) white matter lesion volumes are associated with age and subsequent stroke.
Defective autophagy is known to be associated with age in several cell types and tissues and its dysregulation is related to age-associated diseases.
Defective insulin signalling make neurons energy deficient and vulnerable to oxidizing or other metabolic insults and impairs synaptic plasticity.
Defective LROs are associated with human immune disorders and neurological disease.
Defective melanosomal transfers to cortical keratinocytes and melanin incontinence due to melanocyte degeneration are also believed to contribute to this.
Defective proliferative responses to AdV ( p = @number@ ) were also observed.
Defective SPRTN-dependent clearance of DPCs is the molecular mechanism underlying RJALS , and DPCs are contributing to accelerated aging and cancer.
Defects in autophagy have implications for melanocyte survival and manifestations of skin pigmentary disorders.
Defects in autophagy regulation play a central role in number of diseases , including neurodegenerative diseases , cancer , pathogen infection and metabolic diseases.
Defects in BER have been detected in ageing and neurodegeneration.
Defects in BER have been linked to cancer predisposition , neurodegenerative disorders , and immunodeficiency.
Defects in cellular and intracellular membranes are characteristic of all chronic medical conditions , including cancer , and normal processes , such as aging.
Defects in DNA repair pathways enable cancer cells to accumulate genomic alterations that contribute to their aggressive phenotype.
Defects in endolysosomal and autophagic functions are increasingly viewed as key pathological features of neurodegenerative disorders.
Defects in intercellular coupling in the heart play a key role in the initiation and persistence of malignant arrhythmias.
Defects in maintaining genome integrity are a hallmark of cancer.
Defects in MMR are associated with increased cancer risk in humans and other organisms.
Defects in multiple genome maintenance systems cause human disorders characterized by cancer susceptibility , developmental failure , and premature ageing.
Defects in O-mannosyl glycan on α-DG are the primary cause of a group of congenital muscular dystrophies , which are collectively termed α-dystroglycanopathy.
Defects in telomere length regulation are associated with several diseases as well as with aging and cancer.
Defects in the apoptotic pathways are responsible for both the disease pathogenesis and its therapy resistance.
Defects in the autophagic degradation system are linked to disease pathogenesis and ageing.
Defects of genome maintenance may causally contribute to aging.
Deferiprone is a blood brain barrier permeable , low molecular weight iron chelator that has been used for many years to treat systemic iron disease.
Defibrillator discharge studies have examined the association of air pollution with arrhythmias in sensitive populations.
Deficiencies are associated with specific illnesses.
Deficiencies of vitamins B6 , B12 and folate were found in @number@ @number@ and @number@ subjects respectively.
Deficiency and dampness were important pathological factors for them.
Deficiency citations for safety violations in U.S. nursing homes from @number@ to @number@ are examined ( representing a panel of @number@ observations ) .
Deficiency in energy metabolisms is perhaps the earliest modifiable defect in brain aging and sporadic Alzheimer's disease ( sAD ) .
Deficiency in n-3 polyunsaturated fatty acids ( PUFAs ) is a hallmark of poor nutrition and mood disorders.
Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several neurodegenerative disorders.
Deficiency in the supply of these nutrients increases with aging.
Deficiency in zinc thus compromises proper immune function , like it is observed in the elderly population.
Deficiency of NIX also completely impaired MALM.
Deficiency of p21 prolongs the duration of mitosis by extending metaphase , anaphase and cytokinesis.
Deficient control of irrelevant information with greater age can be demonstrated in paradigms like inhibition of return ( IOR ) .
Deficient feto-placental 11β-HSD2 results in a life-long phenotype of anxiety and cardiometabolic disorders , consistent with early life glucocorticoid programming.
Deficient selection against irrelevant information has been proposed to underlie age-related cognitive decline.
Deficits in both peripheral hearing and central auditory processing ( CAP ) can contribute to ARHI.
Deficits in cholinergic function have been postulated to cause delirium and cognitive decline.
Deficits in dark adapted threshold and log σ were correlated in mild but not in severe ROP.
Deficits in postural control and muscle strength either due to maturation , secular declines or biologic aging are two important intrinsic risk factors for falls.
Deficits in the processing of sensory reafferences have been suggested as accounting for age-related decline in motor coordination.
Deficits were scored @number@ if absent , @number@ if mild , or @number@ if severe.
Defined for each GM region , ChaCo is the percentage of WM tracts connecting to that region that pass through the WML mask.
Defined reference intervals are important for interpreting such data.
Defining aging as successful or unsuccessful has become clinically relevant in the last @number@ years , with an increased recognition of the frail phenotype.
Defining a new cutoff value in these patients would prevent unnecessary laboratory or imaging procedures.
Defining cases and controls on the basis of biomarkers rather than clinical diagnosis may reduce sample sizes required for genetic studies.
Defining optimum function in patients with HF provides clarity of patient communication to and between APNs.
Defining patterns of functional brain plasticity associated with motor practice following stroke could guide rehabilitation.
Defining quality and value for the care of older adults with cancer can be particularly challenging.
Defining the interrelationship among TRPC channels , mTOR signaling , and HDAC enzymes is a promising , but challenging area of research.
Defining the relationship between ageing and cancer is a crucial but challenging task.
Defining these nonhematopoietic factors could have important implications for improving NK cell function in the elderly.
Definitional approaches for EM and its subtypes were constructed from least restrictive to most restrictive.
Definition of BNP level enables to diagnose differentially the difficult forms of congestive heart failure.
Definition of easily transferable , high level pathways with solid evidence-base ; @number@
Definition of OAB was determined as the score of item number @number@ in IPSS ≥ @number@
Definitions and prevalence of fatigue may vary across studies , across diseases , and even between investigators and patients.
Definitions of both sarcopenia and frailty are still developing , and both concepts clearly overlap in their physical aspects.
Definitions of cardiovascular outcomes were highly inconsistent.
Definitions of the pathogenesis of alphaviruses , as well as the host factors influencing disease severity , remain limited.
Definitions of TIA are reviewed , and the importance of neuropsychological evaluation and neuroimaging correlates of TIA in establishing a positive diagnosis will be discussed.
Definitive correction of pelvic organ prolapse can be accomplished through both vaginal and abdominal approaches.
Definitive replication and confirmation of these findings were hindered by potential heterogeneity and by the rarity of the implicated alleles.
Deformable image registration in the presence of considerable contrast differences and large-scale size and shape changes represents a significant challenge for image registration.
Deformation , flattening and sparseness of the intestinal villi were identified.
Degeneracy is a distributed system property that can be observed within individual brains or across different brains.
Degeneracy is a valuable epistemological tool that can transformatively enhance scientific models of bodily ageing.
Degenerated microglia lose their neuroprotective properties , resulting in the formation of neurofibrillary tau tangles and consequently , the neuronal death that causes Alzheimer's dementia.
Degeneration in the neuromuscular system due to aging can affect daily activities that need to be controlled by bimanual coordination with both hands.
Degeneration of IVD is a progressive and irreversible process and can be evaluated with immunohistochemical examination or radiological grading.
Degeneration of neural pathways regulating sleep-wake patterns and sleep architecture may contribute to sleep alterations.
Degenerative ageing processes are to a great extent responsible for organ-specific morbidity and mortality among our population.
Degenerative alterations of the spine occur in an individual-specific manner with increasing age.
Degenerative changes have the potential to greatly disrupt the normal curvature of the spine , leading to sagittal malalignment.
Degenerative changes in the joint cartilage , such as roughness or thinning , were often present , but no cartilage defects were evident.
Degenerative changes produced more anterosuperior translation of the ICR , which was significantly correlated with height loss ( P < @number@ ) .
Degenerative conditions of the central nervous system share a strikingly great deal of similarities , particularly the production and buildup of malfolded proteins.
Degenerative diseases are becoming more common with increasing life expectancy of the human population.
Degenerative diseases are characterized by both cell death and inflammation , which involve different pathways such as apoptosis and pyroptosis.
Degenerative disk disease ( DDD ) is a pathologic condition associated with IVD that has been associated with chronic back pain.
Degenerative skeletal disorders are common and serious problems worldwide , especially in aging populations.
Degenerative spine outcome was good in @percent@ of patients.
Degradation occurred to both adhesive systems with storage , but was greatest for SB.
Degradation of collagen fibrils impairs the structure and function of skin that characterize skin aging.
Degradation of heparan sulfate was observed not only in acutely UVB-irradiated skin , but also in skin chronically exposed to sun.
Degradation of proteins generates peptides and amino acids that can be used for remodelling of impaired pathways and cellular functions.
Degradation of saliva after sampling affects viscosity and slightly pH.
Degradation of the adhesive interface contributes to the failure of resin composite restorations.
Degradation rates were estimated from the average fragment size of denatured DNA run on agarose gels and from qPCR reactions.
Degree of cognitive impairment and cognitive ability was determined via structured clinical interview.
Degree of conversion and rate of polymerization of adhesive systems were evaluated in triplicate using real-time FT-IR.
Degree of diabetic control and association with PD was associated with the 1-year adverse outcomes and infection complications.
Degree of functional impairment increased progressively with number of readmissions.
Degree of glaucoma damage was not consistently associated with choroidal thickness.
Dehydration and hyperosmolarity can be triggered by diminished thirst perception in this population.
Dehydroepiandrosterone ( DHEA ) and its sulfated form dehydroepiandrosterone sulfate ( DHEAS ) are the most abundant circulating steroid hormones in humans.
Dehydroepiandrosterone ( DHEA ) and its sulfate ester ( DHEAS ) are the most abundant steroids in humans , but their levels fall with age.
Dehydroepiandrosterone ( DHEA ) has been reported to improve pregnancy rates and lower miscarriage rates in women with diminished ovarian function.
Dehydroepiandrosterone ( DHEA ) may represent a first such intervention.
Dehydroepiandrosterone sulphate ( DHEAS ) is the most abundant circulating steroid secreted by adrenal glands yet its function is unknown.
Dehydroglyasperin C ( DGC ) is a major isoflavone found in the root of licorice.
Delay discounting AUC did not add significantly to the model ( p = @number@ ) .
Delayed aesthetic results on facial wrinkles were very satisfactory.
Delayed aging could increase life expectancy by an additional @number@ years , most of which would be spent in good health.
Delayed aging would greatly increase entitlement outlays , especially for Social Security.
Delayed cerebral ischemia occurred in @number@ patients ( @percent@ ) , leading to stroke in one of them.
Delayed cutaneous wound healing is implicated in many conditions such as diabetes , aging , stress and alcohol consumption.
Delayed Ejaculation and Associated Complaints : Relationship to Ejaculation Times and Serum Testosterone Levels.
Delayed neurologic deficit occurred in @number@ patients ( @percent@ ) .
Delayed onset hypopigmentation after CO , laser resurfacing can markedly detract from clinical outcomes.
Delayed or inadequate treatment can result in irreversible joint destruction and neurological condition.
Delayed or less intense orgasms may be a natural process of aging due to decreased genital blood flow and dulled genital sensations.
Delayed P3b latency and increased amplitude revealed that middle age adults have a deficit in stimulus processing.
Delayed recall and recognition of LM was enhanced by arousal relative to control , as was recognition of the BVRT.
Delayed responders ( n = @number@ ) were significantly older and less educated than the early responders ( n = @number@ ) .
Delayed surgical repair ( > 48 h ) has been consistently demonstrated to be associated with an increased risk of 30-day and 1-year mortality.
Delayed treatment of pseudoaneurysm leads to bleeding , venous edema at the extremities and compression on the adjacent nerve as a result of pseudoaneurysm enlargement.
Delayed verbal memory was also enriched in one sample of bipolar disorder.
Delayed wound healing was observed in 24-week-old mice.
Delay in diagnosis and start of treatment makes prognosis of their TB poorer.
Delay in diagnosis leads to increase in the area of necrosis with a resulting increase in cosmetic deformity and life-threatening complication.
Delaying LTC expansion could , for example , lead to increased healthcare expenditure and longer wait lists for LTC and acute care patients.
Delaying the decline in skeletal muscle function will be critical to better maintenance of an active lifestyle in old age.
Delays and the economic effects were assessed only after the first @number@ h as an in-patient had elapsed.
Deleterious effects of Aβ on neuronal morphology were reduced by blockade of either CP or CN.
Deletion analysis identified the second domain ( D2 ) within the takusan protein that is required for PSD-95 clustering and synaptic protection from Aβ.
Deletion analysis showed that the basic domain is important for speckle localization.
Deletion of a @number@ bp intronic region flanking the rs2279590 variant through CRISPR-Cas9 genome editing in HEK293 cells demonstrated a decreased clusterin gene expression.
Deletion of Insertion I does not affect tRNA binding but instead reduce the catalytic efficiency of the synthetase.
Deletion of ovarian follicles happens mainly by the mechanism of cell apoptosis.
Deletion of p53 also improved the inhibition of cell growth due to forced expression of progerin.
Deletion of rad16 in an AP endonuclease mutant apn2Δ also accelerated chronological aging.
Deletion of SGF73 dramatically extends replicative lifespan ( RLS ) in yeast.
Deletion of Trp53 rescued the Acvr1 ( CKO ) cell death phenotype in embryos and reduced Acvr1-dependent apoptosis in postnatal lenses.
Deletion of yeast AMPK , SNF1 , or its activator SNF4 abrogated proteasome-mediated lifespan extension , supporting this hypothesis as the AMPK pathway regulates metabolism.
Deliberants also received a briefing book describing biorepository operations and regulation.
Delineating molecular mechanisms influenced by cis-regulatory variants is essential to understand gene regulation and ultimately disease pathophysiology.
Delineating the molecular mechanisms of these processes may provide clues for the novel therapeutic targets for CVA and AD patients.
Delirious patients remained in hospital @number@ days longer ( p < 0.001 ) and had more complications than patients without delirium.
Delirium and coma were identified daily using the Confusion Assessment Method for the ICU and the Richmond Agitation-Sedation Scale , respectively.
Delirium , depression , and dementia are geriatric syndromes and neurocognitive disorders that are the result of cognitive decline associated with pathology.
Delirium duration was measured according to number of hospital days with delirium.
Delirium feature severity was defined as the sum of CAM-Severity ( CAM-S ) scores on all postoperative hospital days.
Delirium incidence and severity were evaluated daily during hospitalization.
Delirium incidence ranged between @percent@ and @percent@.
Delirium is a common condition , and is associated with adverse outcomes , including increased morbidity , increased mortality , and increased health services utilization.
Delirium is a common problem associated with substantial morbidity and increased mortality.
Delirium is a frequent perioperative complication in this population and contributes to increased morbidity and mortality.
Delirium is a neurobehavioral syndrome caused by dysregulation of neuronal activity secondary to systemic disturbances.
Delirium may be prevented in about one-third of patients using a multicomponent intervention.
Delirium risk was communicated to providers via electronic medical record.
Delirium severity and duration were significantly reduced in the ' after ' group.
Delirium severity and occurrence were associated with longitudinal diffusion changes in the periventricular , frontal , and temporal white matter.
Delirium severity and symptoms were evaluated with the Delirium-O-Meter ( D-O-M ) .
Delirium severity in the ICU is not routinely measured because the available instruments are difficult to complete in critically ill patients.
Delirium started the first post-operative day ( 2F ; @number@ M ) and lasted @number@ ± @number@ days.
Delirium was assessed from Confusion Assessment Method ( CAM ) interviews and chart review.
Delirium was assessed twice daily in the first @number@ postoperative days using the Confusion Assessment Method.
Delirium was determined using the Confusion Assessment Method ( CAM ) and chart review.
Delirium was diagnosed by the Confusion Assessment Method.
Delirium was diagnosed using DSM-IV-TR criteria.
Delirium was diagnosed with the Confusion Assessment Method ; severity of delirium was measured with the Delirium Rating Scale Revised-98.
Delirium was diagnosed with the DSM-IV-TR.
Delirium was observed in @percent@.
Delirium was rated by a trained clinical researcher using the CAM-ICU.
Delirium was screened daily with confusion assessment method ( confirmed with diagnostic and statistical manual of mental disorders ( DSM-IV ) -TR ) .
Delirium was screened using Delirium Observation Screening Scale and dementia was assessed from medical notes.
Delivering this in the ED is an evolving area of practice that adapts the principles of geriatric medicine for the urgent-care environment.
Delivery of high-quality , efficient care by qualified providers is essential for the success of any health care system.
Delivery of melatonin and targeting melatonin receptors pose as neuroprotective strategies for stroke therapy.
Delivery of target protectors designed against the miR-339-5p BACE1 @number@'-UTR target sites in primary human brain cultures significantly elevated BACE1 expression.
Delivery of the miR-339-5p mimic also significantly inhibited expression of BACE1 protein in human glioblastoma cells and human primary brain cultures.
Delphinidins dose-dependently inhibit NF-κB- , activator protein-1- as well as COX-2 expression in UV-exposed epidermis.
Delphinidins inhibit the expression of cell adhesion molecules ICAM and VCAM , thus counteracting vascular inflammatory situations.
Delphinidins may counteract skin-aging due to inhibition of UV-induced expression of matrix metalloproteinase in fibroblasts.
Delphinol® significantly reduces oxidative stress ( oxidized LDL and F2-isoprostane ) and blood glucose in controlled clinical trials.
Delta bandpower was also increased in the incident dementia group compared to non-dementia at followup.
Delta lactate was the difference between these measures.
Delusional disorder ( @percent@ ) and schizophrenia ( @percent@ ) are the most frequent diagnoses.
Delusions are partially clinically and neurobiologically linked to memory deficits but not to poor insight.
Demands contributed significantly to poorer functioning ; however , other measures did not.
Demands from offspring , beliefs about support , and rewards from helping explained these racial differences.
Dementia , AD , and VaD were diagnosed according to established criteria via standard diagnostic procedures.
Dementia affects about @percent@ of people age @number@ years and older.
Dementia also complicates clinical care for other co-existing medical conditions.
Dementia and cardiovascular causes appeared as main or contributory causes on @percent@ of certificates , followed by respiratory ( @percent@ ) .
Dementia and cognitive impairment have become the major concerns worldwide due to a significantly aging population , increasing life span and lack of effective pharmacotherapy.
Dementia and gait impairments often coexist in older adults and patients with neurodegenerative disease.
Dementia and MCI subtypes were determined using standard criteria.
Dementia and subtypes were diagnosed following international criteria.
Dementia associated with cerebrovascular disease is common.
Dementia caregiving is associated with elevations in depressive symptoms and increased risk for cardiovascular diseases ( CVD ) .
Dementia diagnoses ( n = 287 ) between @number@ and @number@ were obtained through linkage with hospital discharge , national death and special reimbursement registers.
Dementia diagnosis was extracted from the two Swedish registers.
Dementia diagnosis was the study outcome.
Dementia did not modify these findings.
Dementia disorders were defined according to standard criteria.
Dementia-exclusive care or dementia care units were more common as community size increased.
Dementia-friendly environments , culture , and domesticity are key factors for such interventions.
Dementia had been diagnosed in @percent@ ( n = @number@ ) in home care and in @percent@ ( n = @number@ ) in residential care.
Dementia has become a common diagnosis in aging populations , and the numbers will increase in the forthcoming years.
Dementia has become a priority worldwide in terms of both public health and social care due to its rapidly increasing burden in communities.
Dementia has emerged as a major societal issue because of the worldwide aging population and the absence of any effective treatment.
Dementia incidence decreased in successive birth cohorts.
Dementia incidence ( @number@ of @number@ men [ @percent@ ] ) was not different among the @number@ study arms.
Dementia in Parkinson's disease ( PD ) is a serious health issue and a major concern for many patients.
Dementia is a common illness with an incidence that is rising as the aged population increases.
Dementia is a complex condition.
Dementia is a frequent complication of idiopathic Parkinsonism or PD , usually occurring later in the protracted course of the illness.
Dementia is a great challenge to public health in Cuba due to its impact on society and families.
Dementia is a growing concern due to the aging process of the western societies.
Dementia is a major cause of disability and death among older adults.
Dementia is a major concern among growing chronic diseases in the aging society and its association with polypharmacy has not been adequately assessed.
Dementia is among the most frequent causes of disability in the elderly.
Dementia is an acquired highly disabling syndrome common among elderly people.
Dementia is an important risk factor for delirium and is common in frail elderly.
Dementia is a progressive and incurable condition that in one way or another affects nearly everyone.
Dementia is a syndrome associated with a wide range of clinical features including progressive cognitive decline and patient inability to self-care.
Dementia is common among the elderly , regardless of their ethnic background.
Dementia is increasingly being recognized in cases of Parkinson's disease ( PD ) ; such cases are termed PD dementia ( PDD ) .
Dementia is one of the most important public health problems as a result of the rapid increase in the number of elderly persons worldwide.
Dementia is receiving increasing attention from governments and politicians.
Dementia is the leading cause of disability among older adults and is the main cause of dependency , financial burden and caregiver stress.
Dementia onset , dementia duration , difference between twins in age at dementia onset and at death , did not correlate with AD pathology.
Dementia pathologies such as Alzheimer's disease ( AD ) are reaching epidemic proportions , yet they are not successfully managed by effective symptomatic treatments.
Dementia prevalence is predicted to double every 20-years : an expected @number@ million in @number@ @number@ million in @number@
Dementia reduces the capacity to perform a visual-based task while standing and thus , appears to disrupt this perception-action synergy.
Dementia-related behavioural issues are typically managed by environmental modification and the use of psychotropics including antipsychotic medications.
Dementia related costs are much lower in Hungary compared to Western European countries.
Dementia represents a substantial financial burden on society , one that is comparable to the financial burden of heart disease and cancer.
Dementia research over the last @number@ years has expanded enormously and has greater international interest now than at any time in history.
Dementia risk per sum score was calculated with Kaplan-Meier estimates.
Dementias are one of the most serious health and socioeconomic issues.
Dementia severity and global cognitive function were assessed using the Clinical Dementia Rating and Cantonese version of the Mini-Mental State Examination , respectively.
Dementia severity was associated with higher expenditures , but comorbidities were the most important predictor of expenditures.
Dementia severity was measured by Clinical Dementia Rating ( CDR ) .
Dementia should remain presented as a stand-alone concept , distinct from frailty or loss of autonomy.
Dementia significantly increased the risk of an unhealthy oral status ( p < 0.001 ) .
Dementia status was also predicted by parental characteristics.
Dementia status was followed-up for @number@ to @number@ years.
Dementia syndromes are prominent among aging-related diseases.
Dementia threatens the capacity to engage in activity , suggesting meaningful activity may be helpful for persons with dementia ( PWDs ) .
Dementia was assessed over @number@ decades later in @number@ survivors of the original cohort , @number@ of whom were assessed for CFPD in @number@
Dementia was defined using ICD-9 codes for presenile , senile , and Alzheimer's type dementia.
Dementia was diagnosed at baseline by clinical assessment and review by a specialist panel.
Dementia was diagnosed by DSM-IIIR.
Dementia was diagnosed in @number@ men ( including @number@ AD , @number@ VaD ) , and cognitive impairment in @number@
Dementia was diagnosed using a two-step procedure by physicians according to DSM-IV criteria.
Dementia was diagnosed using the 10 / 66 dementia diagnostic criteria.
Dementia was found in @percent@ of elderly people.
Dementia was identified from the National Patient and Cause of Death Registries.
Dementia was mentioned less in vascular dementia ( VaD ; @percent@ ) .
Dementia was more frequent in the acromegaly group than in the CG ( p = @number@ ) .
Dementia was the most common PIM-qualifying condition under both versions.
Dementia with Lewy Bodies ( DLB ) is a common neurodegenerative disorder of the aging population characterized by α-synuclein accumulation in cortical and subcortical regions.
Dementia with Lewy bodies ( DLB ) is often associated with occipital hypometabolism or hypoperfusion , as well as deficits in cholinergic neurotransmission.
Demodex are cosmopolitan mites occurring in many species of mammals.
Demodex was detected using in vivo confocal microscopy and conventional light microscopy.
Demographers expect the number of older persons to double to @number@ million - or to @percent@ of the US population - by the year @number@
Demographic , admission , inpatient , and discharge data were compared between groups.
Demographic aging is a worldwide phenomenon , cognitive and behavioral impairment is becoming global burden of nerve damage.
Demographic aging of the population determines the need for the development of geriatric component in the work of medical services.
Demographically , the risk of occurrence increases until old age.
Demographic and blood sample results were collected.
Demographic and cardiovascular risk information was collected and participants were followed for health outcomes.
Demographic and clinical characteristics and the total function score from the FIM ( ™ ) Instrument were examined.
Demographic and clinical characteristics were abstracted and stratified into ETC and TC groups for comparison.
Demographic and clinical characteristics were assessed , including cardiovascular risk factors , current cardiac status , and depressive symptoms.
Demographic and clinical characteristics were extracted from the medical records.
Demographic and clinical covariates were obtained.
Demographic and clinical data for acute diarrhea among outpatients older than @number@ years were collected from @number@ participating hospitals from @number@ to @number@
Demographic and clinical data , including total number of medications and STOPP / START criteria met , were collected.
Demographic and clinical data were collected.
Demographic and clinical data were examined , and regression analysis was used to determine associations with HRQoL scores.
Demographic and clinical data were obtained at baseline , and social support measures were administered at baseline and at @number@ weeks.
Demographic and clinical parameters can affect LOS and polypharmacy was the strongest and the only common risk factor in both groups.
Demographic and cognitive variables were harmonized , and similar diagnostic criteria were applied to both samples retrospectively.
Demographic and health data were established.
Demographic and health factors were related to profiles.
Demographic and knee pain data were obtained by questionnaire.
Demographic and lifestyle data were recorded based on physical examinations and questionnaires.
Demographic and medication information , cognitive function , visual acuity and manual dexterity were recorded.
Demographic and neuropathologic characteristics were correlated with the Clinical Dementia Rating-Sum of Boxes in the @number@ subjects meeting these criteria.
Demographic and other self-reported related factors were taken into consideration.
Demographic and personality characteristics moderating or mediating effects of chronic stress in caregivers were also reviewed.
Demographic and pregnancy-related data were also collected.
Demographic and pre-operative function and albumin data was collated retrospectively.
Demographic and questionnaire data were collected from @number@ participants , and in-depth interviews were conducted with @number@ participants.
Demographic and social changes in the last decades have resulted in improvements in health and longevity.
Demographic and social trends lead to a variety of micro-level and internal structural contexts that influence caregiving in families with older members.
Demographic and surgical factors were also collected for analysis.
Demographic and treatment characteristics were compared for survivors with and without subsequent neoplasms.
Demographic , anthropometric and biochemical features were collected according to a standard protocol.
Demographic , behavioral , and physical activity factors affect suicidal attempts mostly through depressive symptoms.
Demographic , behavioral , and physical activity factors have indirect effects on suicidal attempts.
Demographic changes across the country are leading to an increased proportion of older Americans.
Demographic changes are associated with a steady increase of older patients with end-stage organ failure in need for transplantation.
Demographic changes in developed countries as their populations age lead to a steady increase in the consumption of standard blood components.
Demographic changes strongly affect industrialized countries.
Demographic characteristics , anthropometry , skeletal muscle mass measured by dual X-ray absorptiometry ( DXA ) , 6-m gait speed and handgrip strength were collected.
Demographic characteristics , average neuropsychological test performance , and sample frequencies and conversion rates were calculated for each classification.
Demographic characteristics , health-related and work-related factors were assessed with a questionnaire.
Demographic characteristics , history of measles and vaccine immunization were investigated by questionnaire.
Demographic characteristics , surgery-related factors , and results of comprehensive geriatric assessment ( CGA ) were all used to develop the prediction model.
Demographic , clinical and biological data were collected.
Demographic , clinical and outcome data from computerized discharge records were collected.
Demographic , clinical and treatment characteristics from antiretroviral-naïve patients who first received combined antiretroviral therapy between Jan / 1996 and Dec / 2010 were collected.
Demographic / clinical details were collected via questionnaire.
Demographic , clinical indices , radiology , spirometry , bacteriology , anxiety and depression were also assessed.
Demographic corrections for cognitive tests should improve classification accuracy by reducing age or education biases , but empirical support has been equivocal.
Demographic correlates of negative attitudes about depression were moderate to weak.
Demographic data and health history were self-reported , and an annual standardized examination measured clinical status.
Demographic data and medical histories were collated from medical records and then correlated with LAA morphology.
Demographic data and the MADRS scores between the early response responders and the early response nonresponders and between the NER-Rs and the NER-NRs were compared.
Demographic data as well as sensitivity and specificity were recorded from the selected studies.
Demographic data , Charlson's Comorbidity Index ( CCI ) score , time to surgery and length of stay ( LOS ) were recorded.
Demographic data , including prospective resident data , were acquired from the Korean Statistical Information Service ( KOSIS ) for 1994-2033.
Demographic data , medical conditions , hospitalizations , and cognition were recorded.
Demographic data , medical history , co-morbidity and medication use and changes were documented.
Demographic data , operative and postoperative outcomes were analyzed.
Demographic data , operative and postoperative outcomes were analyzed.
Demographic data were analyzed using descriptive statistics.
Demographic data were collected and means , deviations , and ranges of all the measures were evaluated.
Demographic details were ascertained by patient interview and routine record review.
Demographic , diagnosis , and transplant information was obtained from the medical record.
Demographic factors did not fully explain correlations between personality and cognitive ability or cohort differences in personality.
Demographic factors ( educational level , marital status , having children ) were registered.
Demographic factors for each category were compared.
Demographic features , ICH characteristics , and LA severity as assessed by van Swieten score on brain CT were compared between the two groups.
Demographic , haemodynamic and biochemical data were drawn from participants in the Anglo-Cardiff Collaborative Trial.
Demographic indicators forecast that by @number@ the elderly will account for about one-third of the global population.
Demographic information and assessments for delirium risk factors were recorded by research staff within @number@ h of admission to the ward.
Demographic information and immunohistochemical results were recorded.
Demographic information , fracture type , concomitant injuries , and management were recorded.
Demographic information , mental and health features were obtained through questionnaires.
Demographic information was collected on previous childcare experiences , the home environment and clinical information relating to the child and the family.
Demographic information was self-reported.
Demographic , laboratory and echocardiographic data were obtained to analyze correlates of LVDD and HFpEF using univariate and multivariate Logistic analysis.
Demographic parameters , ventricular frontal-occipital horn ratio , associated brain malformations , genetic alterations , and surgical treatments were recorded.
Demographics and risk factors were assessed.
Demographics , comorbidities , surgical data , and complications were investigated.
Demographics , education , income , comorbidities , lifestyle variables , and apolipoprotein E ( APOE ) ε4 status were included in adjusted analyses.
Demographics , medical histories , and medications usage were obtained using questionnaire.
Demographics , mental health , and frequency of Internet use were also measured.
Demographic , social network , and morbidity factors are independently associated with both depressive symptoms and suicidal thoughts.
Demographics , vascular risk factors , and stroke data were collected.
Demographics , vitamin B12 and folate levels were studied.
Demographics , year of injection , topical anesthetic usage , touch-up injection , and adverse effects ( AE ) were recorded.
Demographic theory includes three main strands mutation accumulation , stochastic vitality , and optimal life histories.
Demographic variable associated with posttransplant employment included young age , male sex , college degree , Caucasian race , and pretransplant employment.
Demographic variables ( especially age and gender ) affected most of the MCQ scale scores.
Demographic variables , physical activity , comorbidities , medications , pain , and functional scales related to the knee joints were recorded.
Demography , education , and Mini-Mental State Evaluation score were not different between the patient groups.
Demotivation results from a pathological process that is not a part of normal ageing.
Demyelination in the central nervous system ( CNS ) leads to severe neurological deficits that can be partially reversed by spontaneous remyelination.
Dendrimer-RSV complex could also be added to other product forms for additional purposes and applications.
Dendrimer with RSV has led to an innovation in anti-aging cream and solutions that could be commercially marketed.
Dendritic cell ( DC ) vaccines induce T-cell responses in cancer patients.
Dendritic cell density significantly correlated with corneal staining and OSDI ( P < @number@ ) .
Dendritic cell density was higher in DED than in group @number@ ( P < @number@ ) .
Dendritic cell density was higher in glaucoma groups and DED than in controls ( P < @number@ ) .
Dendritic cells ( DCs ) are central in regulating both innate and acquired immunity , but their possible age-related functional modifications are still unclear.
Dendritic cells ( DCs ) are critical for the generation of T-cell responses.
Dendritic cells ( DCs ) play an important role in both immunological tolerance and immunity as well as in pro- and anti-inflammatory responses.
Dendritic cells were significantly higher at limbus than at central cornea in both groups.
Dengue fever is the most common arboviral disease worldwide.
Dengue virus , primarily transmitted by the Aedes aegypti ( L. ) mosquito , has rapidly expanded in geographic extent over the past several decades.
Denosumab , a more recently approved anti-resorptive medication has also been associated with AFF.
Denosumab was generally well tolerated in clinical trials , although long-term effects of very low bone turnover remain to be established.
De novo methylation of CpG islands is seen in many cancers , but the general rules governing this process are not known.
De novo mutations could account for a sizable number of apparently sporadic ALS patients carrying mutations of ALS-related genes.
De novo mutations of coding-genes were found in all the subjects , but they could not be definitively identified as a cause of developmental delay.
Dense area and total breast area were assessed using planimeter measurements from screening mammograms.
Dense area declined similarly , but the absolute magnitude of the rate of increase of nondense area was almost double that of dense area.
Densities of NPs and of NFTs were assessed in several neocortical regions and in the hippocampus , entorhinal cortex , and amygdala.
Densities of rods / aggregates were fourfold greater in AD compared with aged-matched control brains and rods / aggregates were significantly larger in AD brain.
Density and continuity of circumferential and longitudinal elastin in the CCA and ICA decreased with age.
Density functional calculations ( B3LYP / 6-311 + + G ) support the radical-scavenging abilities of the oak phenolics.
Density gradient centrifugation of OSRC-2 and 786-O exosomes confirmed the co-presence of CA9 with exosomal markers.
Density gradient centrifugation revealed the co-presence of GGT1 subunits with CD9 in exosomes isolated by differential centrifugation from human serum.
Dental care should be an important part of geriatric health promotion program and fixed-denture is a preferred choice over removable-denture.
Dental composites develop residual stresses during polymerization due to shrinkage.
Dental examinations were conducted among @number@ inhabitants from @number@ randomly-selected households of @number@ rural communities of the Ziway-Shala lake basin of the Main Ethiopian Rift.
Dental health is often neglected in the older persons , and dental conditions associated with aging are complex , adversely affecting the quality of life.
Dental hygiene students perceived one task as being less dentist-centered after the intervention : radiograph for cariologic diagnosis ( p = 0.041 ) .
Dental status was determined by decayed , missing , and filled teeth ( DMFT index ) .
Dental treatment was continually provided for all participants during follow-up.
Dental zirconia can no longer be considered un-bondable to tooth tissue.
Dentate participants had @percent@ of their restorative care needs unmet , and @percent@ needed oral hygiene instruction plus removal of calculus on their teeth.
Dentin biomodification prevented substantial aging at the hybrid layer and underlying dentin after @number@ months storage.
Dentin in permanent teeth rarely undergoes resorption in development , homeostasis , or aging , in contrast to bone that undergoes periodic resorption / remodeling.
Dentin slabs from the @number@ months of aging group were demineralized for transmission electron microscopy examination of collagen matrix ultrastructural changes.
Dentists may wish to learn more about benefits of probiotics.
Dentition status was associated with age , gender , education and disability.
Deoxyhemoglobin reduces nitrite to nitric oxide ( NO ) .
Deoxyribonucleic acid replication and protein synthesis using [ ( @number@ ) H ] -thymidine and [ ( @number@ ) S ] -methionine incorporation were measured.
Dependence on assistance may affect self-sufficiency.
Dependence on caregivers and cognitive impairment represent two major risk factors in the elderly , especially in frail patients after surgery under general anesthesia.
Dependency worsened in @percent@ of patients , and @percent@ of patients lost self-sufficiency.
Dependent measures were weekly behavioral observations and postmortem neurogenesis levels.
Dependent variables are life and work stress.
Dependent variables were Box-Cox transformed to meet linear regression assumptions.
Dependent variables were frailty , dependency and mortality.
Dependent variables were IL-6 , sCD14 , and D-dimer quartiles.
Dependent variables were suicidal ideation in the last @number@ weeks and last @number@ months.
Dependent variable was EM , assessed by a 10-item instrument that has been widely used in social studies.
Depending of their activation level , FoxO proteins can exhibit ambivalent functions.
Depending on age , the incidence , prevalence , mortality rate , and disability outcome of stroke differ between the sexes.
Depending on task combination , dual-tasking can either be performed successfully or can lead to performance decrements in one or both tasks.
Depending on tea quality , the samples resulted in water soluble fractions of @date@ @percent@.
Depending on the actual situation , activated microglia display specific effector functions supporting inflammation , tissue remodeling , synaptic plasticity and neurogenesis.
Depending on the defining criteria , prevalence of metabolic syndrome ranged from @percent@ to @percent@.
Depending on the location and severity of damage , the neurons succumb to death through the apoptotic , autophagic and necrotic pathways.
Depending on the organism in which the stem cells exists , they divide to the plant or animal ones.
Depending on the procedure , higher hospital volumes were attributable to an increasing number of cases nationwide , an increasing market concentration , or both.
Depending on the skeletal site , peak bone mass occurs by the end of the second or early in the third decade of life.
Depending on the specific C-511 T genotype , different network clusters could predict the cognitive tests.
Depending on the stimulus received , these dense forms might be considered as undifferentiated cells , with the capacity to develop along several different routes.
Depending on the subtype of dementia , the ratio of male to female prevalence differs.
Depending on the type and extent of scarring , a multimodal approach is generally necessary to provide satisfactory results.
Depending on the wave , the median survival of people with FI more than @number@ ranged @number@.84-2.04 years.
Depending upon its organization , movement variability may reflect poor or flexible control of a motor task.
Depleting normal lamin A or inducing mutant lamin A expression are each sufficient to drive nucleolar expansion.
Depletion experiments in aged mice revealed TIMP2 to be necessary for the cognitive benefits conferred by cord plasma.
Depletion of 53BP1 rescues the formation of BRCA1 damage foci in CSB-knockout cells.
Depletion of APTX causes mitochondrial dysfunction and renders the mitochondrial genome , but not the nuclear genome susceptible to damage.
Depletion of cellular polyamines also increased CELF1 and enhanced CELF1 association with Myc mRNA , thus suppressing MYC translation.
Depletion of either adaptor , however , significantly inhibits endocytosis of transferrin and epidermal growth factor.
Depletion of endothelial-derived MPs from ACS patients reduced the induction of senescence.
Depletion of HuR stabilizes the NPM mRNA , increases NPM protein levels and inhibits myogenesis , while its overexpression elicits the opposite effects.
Depletion of OTUD3 leads to the activation of Akt signalling , induction of cellular transformation and cancer metastasis.
Depletion of p31S6K1 with small interfering RNAs ( siRNAs ) partially restored adipogenesis of Sam68-deficient preadipocytes.
Depletion of reparative capacity as reflected by loss of CPCs may presage overt disease as exemplified in this pre-diabetes model.
Depletion of these proteins by RNA interference decreased senescence induced by ARHGAP18 and by H₂O₂.
Depletion of TRiC causes loss of TCAB1 protein , mislocalization of telomerase and scaRNAs to nucleoli , and failure of telomere elongation.
Deposition of perirenal adipose tissue has been associated with adverse renal and cardiovascular events.
Deposition of ubiquitin conjugates on inclusion bodies composed of protein aggregates is a definitive cytopathological hallmark of neurodegenerative diseases.
Depositions or narrowing of nerve structures can cause lasting pain or focal neurological deficits , such as paralysis or sensitivity disorders.
Deprescribing is defined as the reduction , withdrawal , or discontinuation of inappropriate medication.
Deprescribing is the process of tapering or stopping drugs , aimed at minimizing polypharmacy and improving patient outcomes.
Depressed abstainers more often used benzodiazepines but less often used antidepressants , and they had a poorer cognitive function than depressed moderate drinkers.
Depressed at-risk drinkers were more often smokers and had fewer functional limitations but more severe depressive symptoms than depressed moderate drinkers.
Depressed CDR @number@ subjects had significantly higher rates of functional decline and lower rates of improvement in CDR than their non-depressed counterparts.
Depressed individuals experienced lower positive affect throughout the day , while differences in distressed affect were more pronounced in the morning.
Depressed mood was ascertained from the 5-item Mental Health Inventory Screening test.
Depressed older adults who reported executive functioning complaints at baseline demonstrated a slower response to escitalopram treatment than those without executive functioning complaints.
Depressed subjects have a two-fold increased risk of CV events than non-depressed ones.
Depression and aggression in Alzheimer's disease ( AD ) are @number@ of the most severe and prominent neuropsychiatric symptoms ( NPS ) .
Depression and anxiety are highly interrelated , but only very few studies examined the association between 25 ( OH ) D and anxiety.
Depression and anxiety were assessed using the Geriatric Mental State examination ( GMS-AGECAT package ) , providing subthreshold level and case-level diagnoses.
Depression and caregiver burden were the most common outcomes evaluated.
Depression and chronic pain are highly prevalent in elderly populations.
Depression and cognitive impairment are both common disorders in elderly people and frequently occur together.
Depression and diabetes negatively affect cognitive function and are independent risk factors for mild cognitive impairment and Alzheimer‟s disease ( AD ) .
Depression and previous occupation had an interaction effect upon QoL.
Depression and psychotropic medication use are potential risk indicators that are independent of FRAX estimates.
Depression and sleep disorders occur at a higher rate in patients with diabetes compared with controls.
Depression and social support are important moderators of functional improvement after TC among Latino seniors.
Depression and stress were the first and second highest cause of productivity loss respectively.
Depression and substance use were also negatively associated with quality of life.
Depression and the number of comorbidities were assessed by questionnaire and medical file audit.
Depression , anxiety and stroke were found to have the greatest impact on outcomes.
Depression ( CES-D≥16 ) occurred almost twice as often in patients with cognitive impairment ( RR @number@ 95%-CI : @number@.1-3.0 ) .
Depression commonly occurs in conjunction with a variety of medical conditions.
Depression debilitates the lives of millions and is projected to be the second leading disease burden worldwide by @number@
Depression declined with age and did not differ by diabetes status in the oldest respondents ( P = @number@ for age-diabetes interaction ) .
Depression did not have any influence on this scale in our AD group.
Depression , euphoria , night time behavior , and appetite did not significantly increase over this period.
Depression in AD patients is associated with greater impairment of the quality of life and an increased caregiver burden.
Depression in late life has been associated with reduced quality of life and increased mortality from both suicide and illness.
Depression in old age significantly decreases the quality of life and may lead to serious consequences , such as suicide.
Depression in older adults is often overlooked and dismissed as a part of aging.
Depression in older men is characterized by an ongoing negotiation of limited statuses and roles given dominant conceptions of masculinity.
Depression in the context of dementia is common and contributes to poorer outcomes in individuals and those who care for them.
Depression in the elderly is a significant health issue that has the potential to seriously affect physical and emotional well-being.
Depression is defined as a cognitive syndrome and risk factor for AD requiring aggressive targeted intervention.
Depression is recognized as a predictor of increased cardiac morbidity and mortality.
Depression is the leading cause of non-fatal disease burden in Australia.
Depression levels were assessed using the Beck Depression Inventory-Ia ( BDI ) scale.
Depression might be associated with changes in serum levels of VEGF in AD patients.
Depression , obesity , and hypercholesterolemia occurred more often in individuals with low-AD-likelihood , compared with those with a high-AD-likelihood.
Depression , physical function , and disability were measured at baseline and @number@ weeks.
Depression ( p = @number@ ) was significantly decreased , and social support ( p < @number@ ) was significantly increased.
Depression prevalence in sub-samples by dementia status , living place , and socio-demographics were compared.
Depression prevalence was lower in the dementia-free sample as compared to the total population.
Depression , previous mood disorder , prior history of stroke , and cognitive impairment were found to be the most important risk factors for suicide.
Depression scores decreased to reach a plateau after @number@ weeks.
Depression scores were obtained using the Beck Depression Inventory-II and functional impairment was assessed using the functional activities questionnaire ( FAQ ) score.
Depression screening and treatment for older men should be accompanied by alcohol screening and treatment and vice versa.
Depression screening in older adults with vascular risk-factor burden may provide an avenue for prevention of late-onset depression.
Depression severely affects older adults in the United States.
Depression severity , somatic symptom severity , and female gender were also positively associated with the use of psychotropic drugs.
Depression significantly decreased ( p = 0.021 ) in the MT group.
Depressions were identified by regular interview and continuous monitoring of medical records.
Depression was also associated with persistent mild cognitive deficits in CDR @number@ subjects.
Depression was ascertained through the 20-item Center for Epidemiologic Studies-Depression ( CES-D ) , with ≥16 indicating depressive symptoms.
Depression was assessed by the Geriatric Depression Scale-Short Form ( GDS-SF ) and loneliness by UCLA loneliness scales.
Depression was associated with increased pain.
Depression was defined as a score below @number@ on the Short Form-36 mental component summary score.
Depression was defined as total score of @number@ or more on the 15-item Geriatric Depression Scale.
Depression was defined by a score of ≥ @date@ on the validated Geriatric Depression Scale and confirmed by psychogeriatric specialists.
Depression was determined using the Geriatric Mental State Schedule , and depression severity was evaluated with the Geriatric Depression Scale.
Depression was measured using the 15-item geriatric depression scales ( SGDS-K ) .
Depression was measured using the self-rated 15-item Geriatric Depression Scale.
Depression was not shown to be a barrier to insulin therapy.
Depression was operationalized through the Geriatric Depression Scale ( GDS-15 ) and / or use of antidepressants.
Depression was significantly associated with onset of disability after adjustment for health status but not with progression of disability.
Depressive affect and somatic symptoms were the first factor while positive affect was loaded as the second factor.
Depressive and anxiety symptoms and aphasia / dysarthria were independent predictors of participation restrictions.
Depressive and anxiety symptoms were measured by questionnaire.
Depressive disorders were determined using the Chinese version of the Structured Clinical Interview for DSM-IV.
Depressive episode co-occurring with tuberculosis was associated with significantly worse health status across all six domains compared to tuberculosis alone.
Depressive illness with psychotic symptoms was the cause of psychiatric problems in the majority of persons with PWS due to deletion ( @percent@ ) .
Depressive-like behavior was evaluated by using motivational and self-care behavior , including the assessment of the animal's coat state and grooming behavior.
Depressive mood , loss of interest , and anxiety are among the most marked symptoms of depression in AD patients.
Depressive mood was assessed by GDS.
Depressive symptomatology , anxiety , and complicated grief served as need factors , with higher levels resulting in higher probability of service utilization.
Depressive symptomatology associated with HC complaints , suggesting certain themes are affect-driven , while complaints in MCI are associated with organically driven functional impairment.
Depressive symptomatology was measured using the 8-item Center for Epidemiological Studies-Depression ( CES-D ) scale.
Depressive symptoms and cognitive decline are associated in older age , but research is inconsistent about whether one condition influences the development of the other.
Depressive symptoms and hopelessness may be important to the relation between personality disorders and suicide risk.
Depressive symptoms and social capital were measured with a questionnaire.
Depressive symptoms and unhappiness may form a mental health cluster in the elderly , distinct from anxiety symptoms , perceived stress , and felt loneliness.
Depressive symptoms , anxiety symptoms , negative life events , and inadequate emotional support were assessed , and a summary psychosocial risk index was created.
Depressive symptoms are associated with increases in pain and functional limitations in knee osteoarthritis ( OA ) .
Depressive symptoms are common in older adults and are particularly prevalent in those with or at elevated risk for dementia.
Depressive symptoms are important risk factors for insomnia , and depression is considered an important comorbid condition in patients with chronic insomnia of any etiology.
Depressive symptom scores were assessed using the Centre for Epidemiological Studies Depression Scale ( CESD ) , administered in @number@ @number@ and @number@
Depressive symptoms could not fully explain the observed associations.
Depressive symptoms had a prevalence of @percent@ in the overall sample.
Depressive symptoms in older subjects are accompanied by lower nocturnal BP fall and are significant independent determinants of SBP variability.
Depressive symptoms mediated the relationship between obsessive-compulsive symptom severity and obsessive-compulsive related impairment.
Depressive symptoms significantly mediated the associations between negative emotionality and the peak to bed slope.
Depressive symptoms were annually evaluated by the GHQ-12 , with scores of five or higher indicating clinically significant depression.
Depressive symptoms were assessed at baseline and after @number@ years of follow-up using the eight-item Centre of Epidemiological Studies Depression ( CES-D ) scale.
Depressive symptoms were assessed by the Center for Epidemiological Studies Depression Scale.
Depressive symptoms were assessed by the Center for Epidemiologic Studies Depression Scale.
Depressive symptoms were assessed using the 15-item Geriatric Depression scale ( GDS ) .
Depressive symptoms were assessed using the Center for Epidemiologic Studies-Depression Scale.
Depressive symptoms were assessed using the Centre for Epidemiological Studies Depression Scale administered at three time points for @number@ years.
Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale ( CES-D ) six times from 1995 / 1996 to 2011 / 2012.
Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression scale , persons with clinically relevant depressive symptoms were interviewed to diagnose DSM-IV-depressive disorder.
Depressive symptoms were assessed with the four-item Center for Epidemiologic Studies Depression Scale.
Depressive symptoms were assessed with the Geriatric Depression Scale.
Depressive symptoms were assessed with the Patient Health Questionnaire-2.
Depressive symptoms were associated with difficulties in basic and instrumental activities of daily living , but not with sexual practice.
Depressive symptoms were evaluated by GHQ-12 and scores of five or higher indicated CSDS.
Depressive symptoms were measured by the Patient Health Questionnaire-9.
Depressive symptoms were measured by the Patient Health Questionnaire ( PHQ-9 ) .
Depressive symptoms were measured by the Patient Health Questionnaire ( PHQ-9 ) .
Depressive symptoms were measured through Patient Health Questionnaire-9.
Depressive symptoms were measured using the Center for Epidemiological Studies Depression @number@ Scale ( CES-D10 ) .
Depressive symptoms were measured using the Center for Epidemiologic Studies Depression Scale ; pain was measured with an adapted version of the Nottingham Health Profile.
Depressive symptoms were measured with the Center for Epidemiologic Studies Depression ( CES-D ) scale.
Depressive symptoms were measured with the Patient Health Questionnaire ( PHQ ) , and elevated symptoms were defined as a PHQ total score of ≥10.
Depressive symptoms were more strongly associated with sedative-hypnotic use than insomnia or worry.
Depressive symptoms were most often found in residents of psychogeriatric units in residential homes.
Depressive symptoms were most strongly and consistently associated with sleep disturbance.
Depressive symptom trajectories were defined with group-based models.
Deprivation-related inequities across the whole population favoured groups with higher SES ( HII estimates not significant ) .
Deprivation-related inequities among women significantly favoured groups with higher SES ( HII = @number@ [ @number@ ; @number@ ] .
Deprivation-related inequities in DMP enrolment favoured women living in less deprived areas relative to those living in areas with higher deprivation.
Deprivation tertiles for each community pharmacy were calculated using the IMD @number@ deprivation index.
Deprotected telomeres undergo changes in chromatin structure and elicit a DNA damage response ( DDR ) that leads to cellular senescence.
DE proteins also showed a significant association with several neurologic disorders ; for example , Alzheimer's disease and schizophrenia.
Depth of focus was estimated from through-focus objective optical quality.
Depth of focus was statistically significantly higher in the Crystalens eyes than in the control groups.
Depth of PECAM-1 positive cross bridges decreased progressively after birth.
Depth of t-m transformation increased to an average of @number@ µm.
Deregulated expression of glycolytic enzymes contributes not only to the increased energy demands of transformed cells but also has non-glycolytic roles in tumors.
Deregulated miRNAs came out from cells and frequently circulate in extracellular body fluids as part of various human diseases.
Deregulated proliferation is key to tumor progression.
Deregulated β-adrenoceptor / cAMP-PKA pathway is implicated in a range of human diseases , such as neuronal loss during aging , cardiomyopathy and septic shock.
Deregulation of MRRS following oncogene activation or loss-of-function of caretaker genes may be the cause of chromosomal aberrations that promote cancer initiation and progression.
Deregulation of Notch signaling and stabilizing mutations of Notch1 have been linked to leukemia development.
Deregulation of the translational machinery is emerging as a critical contributor to cancer development.
De-repression and precocious expression of Prss29 in the oviduct of Wt1 + / - mice interferes with pre-implantation development.
Der f 14-N showed the highest capacity to induce cell proliferation in murine lymphocyte and human peripheral mononuclear cells among Der f 14-derived fragments.
Der f 14-N showed the highest IgE-binding frequency among Der f 14-derived fragments in patients allergic to house dust mite by enzyme-linked immunosorbent assay.
Derivative procedures are preferred by pancreatic surgeons , but the optimal management of remnant pancreatic stump remains controversial.
Deriving trajectories based on dietary patterns , rather than dietary scores , produced similar findings.
Dermabrasion can be taken down layer by layer to remove the proper level of skin , so that the desired effect is obtained.
Dermabrasion is a form of resurfacing that mechanically alters the skin at the level of the dermis , to promote collagen remodeling and re-epithelialization.
Dermal and epidermal structures in human skin change during intrinsic and extrinsic aging.
Dermal and subepidermal nonechogenic band ( SENEB ) thicknesses were measured.
Dermal CD271 + cells in patients were significantly reduced compared with in healthy controls.
Dermal deposits of mucin in the legs have been described associated with venous insufficiency.
Dermal elasticity was measured using a non-invasive , in vivo suction skin elasticity meter , Cutometer ( ® ) .
Dermal fibroblasts are responsible for the generation of mechanical forces within their surrounding extracellular matrix and can be potentially targeted by anti-aging ingredients.
Dermal fibroblasts constitutively express all components of Fas associated apoptosis , including caspase-8 , an initiator enzyme of apoptosis.
Dermal fibroblasts constitutively expressed distinct sets of chemokine mRNA.
Dermal fibroblasts from human female donors aged 20-67 years were studied in primary culture at low population doubling.
Dermal fibroblasts provide a paradigmatic model of cellular adaptation to long-term exogenous stress and ageing processes driven thereby.
Dermal filler and neurotoxin treatments around the periorbital area are assessed when addressing the early signs of aging.
Dermal filler augmentation of the temples can counteract volume loss and achieve a more balanced and youthful appearance.
Dermal filler injection is a cornerstone of facial rejuvenation procedures.
Dermal fillers are a cornerstone in the approach for facial sculpturing.
Dermal fillers have been used for decades in soft tissue augmentation.
Dermally expressed genes were significantly downregulated in psoriatic biopsies , most likely because of expansion of the epidermal compartment.
Dermal multipotent stem cells ( dMSCs ) are a population of adult stem cells derived from dermis in recent years.
Dermal products from the tea extracts were designed and manufactured.
Dermal remodeling and stimulation of collagen production are associated with wrinkle reduction.
Dermal remodelling was noted with both low and high microbeam energy treatment parameters.
Dermal thickness was also increased by EBNE supplementation , whereas EBNE administration did not affect the serum estradiol concentration.
Dermatological and other medical uses for BoNT-A are also active areas of research.
Dermatologic history , age , and presence of MGD were recorded.
Dermatologists can laser-treat a wide range of dermatoses , including vascular , pigmentary , textural , benign proliferative and premalignant conditions.
Dermatologist should be aware about various nail changes related to aging and those associated with other dermatoses or systemic diseases.
Dermatologists provided approximately @percent@ of office visit care and performed nearly @percent@ of cutaneous surgeries.
Dermatologists see many patients interested in improving their physical appearance through cosmetic procedures or medical means.
Dermatomyositis ( DM ) is the most common form of IIM.
Dermatoscopic features and scores ( total dermoscopy score TDS ) were statistically compared before COS and after a 6-month follow-up period.
Dermatoscopy and adhesive tape were used to evaluate the appearance and adhesion of surface corneocytes.
Dermoscopic , RCM images , and histopathologic preparations were systematically evaluated for the presence of lentigo maligna ( LM ) criteria.
Describe common adjunctive procedures.
Described here is a method for identifying sirtuin protein interactors.
Described here is a simple and quick method for the isolation of S. typhimurium-containing phagosomes from macrophages by coating the bacteria with magnetic beads.
Describe pertinent surgical anatomy relevant to safe and effective face-lifting techniques.
Describe the common types of facelift procedures , including their strengths and weaknesses.
Describing such fundamental kidney biology serves as a necessary foundation for translational and clinical studies that will advance disease care and prevention.
Description-based tasks emphasize deliberative processing by allowing decision makers to analyze explicit descriptions of choice-reward information.
Description of home care patients in terms of their sociodemographic profile and diagnosis at admission.
Descriptions of the facial expression of pain vary widely on these scales.
Descriptions were coded to classify events into broad content domains based on the nature of the event.
Descriptive alternatives to the term snacking are needed in developing messages for health promotion campaigns.
Descriptive analyses characterized the prevalence of barriers across the hospitals.
Descriptive analyses , correlation analyses , and multivariate linear regression with interaction terms were conducted with the statistics software Stata @number@
Descriptive analyses of select health conditions and behavior variables from all completed surveys were tabulated.
Descriptive analyses were carried out.
Descriptive analyses were completed for all variables in the sample.
Descriptive analyses were conducted to describe indications for transfusions and use of red blood cells ( RBCs ) , platelets , and plasma.
Descriptive analyses were used to estimate the prevalence of SA in those aged 45 + living in private dwellings in the ten provinces of Canada.
Descriptive analyses were used to examine the nature and extent of potentially inappropriate anticholinergic medication use.
Descriptive analysis and binary logistic regression were used , with significance level of @percent@.
Descriptive analysis and generalized linear model were applied , and the samples were stratified by age groups and by sex.
Descriptive analysis and hierarchical logistic regression were performed.
Descriptive analysis and hierarchical logistic regression were performed.
Descriptive analysis based on baseline characteristics was performed and slope-estimated glomerular function rates ( eGFR ) before and after entry to the LCC were calculated.
Descriptive analysis , univariate analysis and estimates of multivariate models through logistic regression ( OR , @percent@ CI ) were realized.
Descriptive analysis was conducted using sampling weights to determine the prevalence of anticholinergic medication use.
Descriptive analysis was used for sociodemographic and professional data and analytical approach was used for the measurements.
Descriptive analysis was used to identify the types and prevalence of adverse events experienced by home care clients.
Descriptive and correlational statistics were employed.
Descriptive and inferential analyses were performed.
Descriptive and inferential statistics were used.
Descriptive and inferential statistics were used for data analysis.
Descriptive and inferential statistics were used to analyze the data.
Descriptive and multivariate procedures using logistic and multiple lineal regression models were used.
Descriptive and qualitative data will be collected to examine implementation of the program and effects on interprofessional / team collaboration.
Descriptive and statistical analysis was performed.
Descriptive data , differences according to weight , correlations and changes over time were examined.
Descriptive statistical analyses and cut-off scores were reported for ErrI.
Descriptive statistical indexes and Chi-square test were used for statistical analysis , while considering p < @number@
Descriptive statistics and inference-statistical analyses were calculated.
Descriptive statistics and linear [ Spearman rank-order ( rs ) ] and nonlinear ( goodness-of-fit ) correlations were performed.
Descriptive statistics and multilevel multivariable regression analyses were applied.
Descriptive statistics and multiple linear regressions were conducted using SPSS version @number@
Descriptive statistics and multiple logistic regression were used to define the objectives , while P < @number@ was considered to indicate significance.
Descriptive statistics and normative ranges ( unweighted and population-weighted ) are provided by age cohort.
Descriptive statistics are included for @number@ cognitively normal individuals.
Descriptive statistics , bivariate analysis , and categorization were used to describe hospice practices.
Descriptive statistics , bivariate- ( chi-square tests ) and multivariate methods ( linear regressions ) were used to examine differences in population health.
Descriptive statistics characterized the sample overall and among black and white women separately.
Descriptive statistics , chi-square and regression analysis were used to test for associations.
Descriptive statistics , correlations and ordinary least square regression analyses with collinearity tests are conducted.
Descriptive statistics detail the demographics , assessment scores , and diagnostic profiles of patients.
Descriptive statistics , independent t-test , chi-square , Pearson correlations , and logistic regression were utilized in analysis.
Descriptive statistics of keratometric cylinder data were analyzed.
Descriptive statistics , one-way and two-way analysis of covariance ( ANCOVA ) were carried out.
Descriptive statistics , simple and multiple linear regression , and linear stepwise multiple regression were performed.
Descriptive statistics , univariate analyses , binary and multivariate logistic regression were used to identify factors and explore factors related to UI absorbent products use.
Descriptive statistics were calculated for each item and site.
Descriptive statistics were computed and compared between the age groups.
Descriptive statistics were performed as well as a weighted kappa coefficient , Spearman's correlation coefficient , Wilcoxon signed-rank test and Bland-Altman plots.
Descriptive statistics were used to analyze demographic characteristics.
Descriptive statistics were used to assess physician perceptions and logistic regression models were used to evaluate predictors of physician perceptions.
Descriptive statistics were used to describe residents ' satisfaction with the CHC.
Descriptive statistics were used to describe the study group.
Descriptive statistics , χ² test , t-test , and Heckman selection model analysis were conducted using SAS @number@
Descriptives , t tests , and chi-square tests analyzed sexual orientation differences.
Descriptive subanalyses involving PreAD-2 suggested greater learning and recall difficulties in these subjects when compared with the PreAD-1 group.
Descriptives were presented by categories of gender , age , level of ID and mobility.
Descriptive thematic analysis was completed on data provided.
Descriptors which encompassed terms related to work ability , aging and elderly were used.
DES Daughters should continue to receive a 2-yearly cytological check-up from their general practitioner until at least the age of @number@
Desialidation of the channel exposes glycan residues that promote binding to galectin-1 , resulting in stabilization of residence on the plasma membrane.
Design.
DESIGN : 12-month prospective cohort study.
DESIGN : 3-cross sectional studies in @number@ @number@ and @number@ respectively.
DESIGN : A 12-week randomized clinical trial.
DESIGN : A 35-year longitudinal and cross-sectional twin study of cognitive aging.
DESIGN : A 7-year prospective observational study was conducted.
Design : A case-cohort study was nested within the Prevención con Dieta Mediterránea trial.
DESIGN : A cohort study ( last follow-up @date@ ) .
DESIGN : A community-based cohort of 50-y-old men was followed for a maximum of > 40 y.
DESIGN : A community-based cross-sectional study.
DESIGN : A community-based Korean Longitudinal Study on Cognitive Aging and Dementia and time-synchronized video-polysomnography ( vPSG ) in a laboratory.
Design : A comparative laboratory study of ovarian tissue obtained from unaffected BRCA mutation carriers ( BMCs ) vs age-matched organ donor cadavers.
DESIGN : a comparison of two epidemiological studies of older people using identical methods.
DESIGN : A controlled study with baseline and follow-up measurements.
DESIGN : A cross-sectional analysis.
DESIGN : a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population.
DESIGN : A cross-sectional and longitudinal study.
DESIGN : A cross-sectional descriptive epidemiological survey using a two-step sampling strategy to obtain a representative community sample.
DESIGN : A cross-sectional , descriptive study.
DESIGN : A cross-sectional design was used.
DESIGN : A cross-sectional , epidemiological study.
DESIGN : A cross-sectional , exploratory study design was used.
DESIGN : A cross sectional feasibility study.
DESIGN : A cross-sectional functional magnetic resonance imaging study of older adults with cardiovascular risk factors.
DESIGN : A cross-sectional , multilevel survey was designed.
DESIGN : A cross-sectional , multilevel survey was designed.
DESIGN : A cross-sectional observational study.
DESIGN : A cross-sectional population-based study.
DESIGN : A cross-sectional population-based study.
DESIGN : A cross-sectional retrospective substudy of an ongoing prospective cohort study.
DESIGN : a cross-sectional retrospective survey was conducted in @number@
DESIGN : a cross-sectional study.
DESIGN : a cross-sectional study.
DESIGN : A cross-sectional study.
DESIGN : A cross-sectional study.
DESIGN : A cross-sectional study.
DESIGN : A cross-sectional study.
DESIGN : A cross-sectional study.
DESIGN : A cross-sectional study.
DESIGN : A cross-sectional study aimed at verifying the possibilities of using diagnostic tools for sarcopenia.
DESIGN : A cross-sectional study based on a quota sample.
DESIGN : A cross-sectional study of @number@ inhabitants aged @number@ and older were conducted in the area of Dujiangyan , China.
DESIGN : A cross-sectional study of outpatients at the Memory Disorder Outpatient Center of Japan's National Center of Geriatrics and Gerontology.
DESIGN : A cross-sectional study of two groups of HIV-infected participants at baseline and follow-up timepoints.
DESIGN : A cross-sectional study that is a second follow-up to the Isfahan Cohort Study ( ICS ) .
DESIGN : A cross-sectional study using a survey administered face-to-face.
DESIGN : A cross-sectional study using convenience sampling.
DESIGN : A cross-sectional study was carried out to evaluate the diverse impacts of aging on IR.
DESIGN : A cross-sectional study was conducted with patients submitted to videofluoroscopy.
DESIGN : A cross-sectional study was used.
DESIGN : A cross-sectional study with a three-year follow-up.
DESIGN : A cross-sectional survey.
DESIGN : A cross-sectional survey.
DESIGN : A cross-sectional survey.
DESIGN : A @date@ randomized trial , stratified by enrollment site and patient health literacy status , with 2-year follow-up.
DESIGN : A descriptive , exploratory research with a convenience sample.
DESIGN : A double-blinded , randomized , controlled trial.
DESIGN : A double-blinded , randomized , controlled trial.
DESIGN : A literature search from @number@ to @number@ was conducted using Medline , CINAHL , PsychINFO , and Google Scholar.
DESIGN : All eligible PEG patients , with and without PU , were cross-sectionally assessed for plasma arginine.
DESIGN : All-night sleep EEG was recorded semiannually for @number@ years.
DESIGN : a longitudinal prospective cohort study.
DESIGN : A longitudinal , quasi-experimental study.
DESIGN : A longitudinal study using data from older persons born between @number@ and @number@
DESIGN : A longitudinal study using information from the Stroke Recovery in Underserved Population ( SRUP ) data base.
DESIGN : A longitudinal study was implemented and data were analyzed using logistic regression models and Cox proportional hazards regression model adjusting for potential confounders.
DESIGN : A longitudinal validation study ( n = @number@ ) and inter-rater reliability study ( n = @number@ ) in a GEM population.
DESIGN : Altogether , @number@ lonely , home-dwelling individuals ( aged ≥75 years ) participated in a psychosocial group rehabilitation intervention.
DESIGN : aMED was evaluated through a validated Mediterranean diet score categorized into quintiles.
DESIGN : A meta-synthesis was conducted following the Joanna Briggs Institute guidelines and using Qualitative Assessment and Review Instrument Software.
DESIGN : A modified Delphi process was conducted.
DESIGN : A multicenter cross-sectional survey was carried out from @date@ to @date@ .
DESIGN : A multicenter international cross-sectional design.
DESIGN : Analyses of data from the English Longitudinal Study of Ageing.
DESIGN : Analyses of data from the English Longitudinal Study of Ageing , an ongoing , open , prospective cohort study initiated in @date@ .
DESIGN : Analyses of nationally representative cross-sectional population surveys , the Health Survey for England ( HSE ) .
DESIGN : Analysis of 9-year prospective cohort data from the New Mexico Aging Process Study.
DESIGN : Analysis of a prospective cohort study.
DESIGN : Analysis of data from the National Health Aging Trends Study.
DESIGN : Analysis of genotype , PCa status , and age to select single nucleotide polymorphisms ( SNPs ) associated with diagnosis.
DESIGN : Analysis of human oocytes with the use of NanoString and immunoblotting.
DESIGN : Analysis of longitudinal data.
DESIGN : analysis of pseudonymous , person-level , data extracted from the administrative data systems of local health and social care organisations.
DESIGN : An analysis of data from SA with a pre-post design was performed.
DESIGN : A narrative literature review was performed to report evidence relating shorter telomeres to the ageing process and inflammation.
DESIGN : a national cohort survey covering RAND Corporation-derived quality indicators ( QIs ) in face-to-face structured interviews in participants ' households.
DESIGN : A nationwide register-based case-control study comparing 70-year-olds with and without schizophrenia.
DESIGN AND ANALYSES : Design and Analyses should be adapted to the objectives with appropriate outcomes and are not different from other clinical trials.
DESIGN AND ANALYSIS : An open-label , observational , 12-month , multicenter , French study.
DESIGN AND METHOD : Data were abstracted from the @number@ Nationwide Inpatient Sample ( NIS ) and odds of death were modeled using logistic regression.
DESIGN AND METHOD : Focus group methodology was used for data collection and analysis.
DESIGN AND METHODS : A approach was adopted.
DESIGN AND METHODS : A approach was adopted.
DESIGN AND METHODS : A cross-sectional , community-based population study of @number@ non-diabetic Japanese residents was conducted.
DESIGN AND METHODS : A cross-sectional survey on @number@ community-dwelling men older than @number@ years of age.
DESIGN AND METHODS : A descriptive pilot study from a convenience sample of @number@ psychiatric patients aged 18-59.
DESIGN AND METHODS : a multicenter cohort study in cardiac surgery wards of two university hospitals with follow-up @number@ months after hospital admission.
DESIGN AND METHODS : A nationwide sample was analyzed , based on a questionnaire with @number@ individuals using elderly care services.
DESIGN AND METHODS : A population-based sample of @number@ community-dwelling individuals aged 65-94 years reported on their sociophysical environment and life satisfaction using questionnaires.
DESIGN AND METHODS : A prospective longitudinal study using the National Longitudinal Study of Adolescent Health Sibling Pairs ( n = @number@ ) .
DESIGN AND METHODS : A qualitative exploratory design , with snowball sampling , identified @number@ well-regarded nurse scholars from Australian universities or clinical health services.
DESIGN AND METHODS : A single blind , randomized controlled trial was conducted.
DESIGN AND METHODS : A systematic literature review was performed , and diagnostic laboratories were surveyed.
Design and Methods : A systematic search of nine databases identified @number@ articles published from @number@ to late @number@
DESIGN AND METHODS : Community-dwelling people aged > 70 years completed a telephone survey.
DESIGN AND METHODS : Data from @number@ trips for @number@ Delaware clients were examined.
DESIGN AND METHODS : Data were gathered from @number@ elders aged 61-93 years in @number@ Bristol Bay communities in Southwest Alaska.
DESIGN AND METHODS : Data were obtained from drug prescription and hospital discharge databases.
DESIGN AND METHODS : In-depth interviews were conducted by phone or in person with each participant.
DESIGN AND METHODS : In Study @number@ we sampled @number@ older persons to verify our hypothetical model in a cross-sectional survey.
DESIGN AND METHODS : @number@ residents from six assisted living facilities completed questionnaires assessing personal experiences as victims of relational aggression and subjective well-being.
DESIGN AND METHODS : Observational retrospective cohort study on @number@ consecutive CO-GHD adults transferred to our unit from @date@ to @date@ .
DESIGN AND METHODS : Quantitative content analysis of a full year's data from @number@ leading online communities using a novel computerized system.
DESIGN AND METHODS : Random effects modeling was utilized with data from a nationwide longitudinal study conducted in Taiwan.
DESIGN AND METHODS : The NYUCI-AC was evaluated within a single-blinded randomized controlled trial.
DESIGN AND METHODS : The present study used a cross-sectional design.
DESIGN AND METHODS : This descriptive study invited community-residing male osteoporosis patients aged 50 + to participate in interviews about osteoporosis.
DESIGN AND METHODS : This qualitative study was conducted as part of the goals of care clinical trial.
DESIGN AND METHODS : This retrospective cohort study used the Medicare Current Beneficiary Survey ( 2000-2005 ) .
DESIGN AND METHODS : This study used the @number@ wave of the National Health and Aging Trends Study.
DESIGN AND METHODS : This study was a cross-sectional survey of primary care clinicians affiliated with @number@ practice-based research networks , @date@ to @date@ .
DESIGN AND METHODS : This study was part of the Chinese Longitudinal Health Longevity Study ( CLHLS ) .
DESIGN AND METHODS : This was a cross-sectional study of @number@ HD patients at an outpatient HD service.
DESIGN AND METHODS : Two hundred and forty-four centenarians from the Georgia Centenarian Study were included in this cross-sectional population-based study.
DESIGN AND METHODS : We engaged in content analysis of activity measures of 5U.S. public use data sets with nationally representative samples of older adults.
DESIGN AND METHODS : We first briefly review and critique influential historical studies to illustrate how the scientific study of social relations developed.
DESIGN AND METHODS : We utilized weighted survey data from Aging with Pride : National Health , Aging , and Sexuality / Gender Study.
DESIGN AND SAMPLE : Focus group methodology was conducted to assess perspectives among these homeless women ( N = 20 ) aged @number@ to @number@
DESIGN AND SAMPLE : Qualitative interviews were conducted with @number@ administrators from the central office of a state department of corrections.
DESIGN AND SETTING : A cross-sectional study conducted in Dujiangyan Sichuan China.
DESIGN AND SETTING : A cross-sectional study in care homes in the UK.
DESIGN AND SETTING : A cross-sectional study of @number@ men aged 40-79 years recruited from eight European centres.
DESIGN AND SETTING : analysis of a cohort of @number@ subjects aged @number@ years old at time of inclusion.
DESIGN AND SETTING : A prospective cohort study.
DESIGN AND SETTING : A prospective observational cohort study in the ICU of two tertiary hospitals between @date@ and @date@ .
Design and Setting : Cohort study using a population-based BMD registry.
DESIGN AND SETTING : : Cross-sectional at a state university.
DESIGN AND SETTING : Cross-sectional study conducted in the public healthcare system of Bauru , São Paulo , Brazil.
DESIGN AND SETTING : Descriptive study evaluating free drug distribution in the State of São Paulo , Brazil.
DESIGN AND SETTING : Morning saliva samples were obtained from participants in a cross-sectional probability-sample survey of the general British population ( Natsal-3 ) .
DESIGN AND SETTING : prospective cohort study.
DESIGN AND SETTING : Prospective observational study conducted in @number@ acute care medical wards throughout Italy.
DESIGN AND SETTING : Randomized , controlled trial in nursing homes.
Design and Setting : Randomized crossover trial of CPAP vs CPAP withdrawal.
DESIGN AND SETTING : Studies were performed in the Clinical Research Center of an academic medical center.
DESIGN AND SETTING : The CARDIA study followed @number@ Black and White individuals aged 18-30 years in 1985-1986 ( year @number@ ) .
DESIGN AND SETTING : This was a 5-year prospective population-based study of Australian community-dwelling older adults.
DESIGN AND SETTING : This was a randomized , double-blind , placebo-controlled study in a single center.
DESIGN AND SETTING : Two consecutive observational prospective cohorts in four hospitals in the Netherlands.
DESIGN AND SETTING : We conducted a prospective , longitudinal study at a university hospital and research institute.
DESIGN AND SETTING : We identified studies through a systematic literature search and the Thyroid Studies Collaboration , a collaboration of prospective cohort studies.
DESIGN AND SETTING : We recruited @number@ healthy male siblings aged 25-45 years in a cross-sectional , population-based study.
DESIGN AND SETTING : We systematically harvested every article published by ADC investigators and used social network analysis to analyze copublication networks.
DESIGN AND SUBJECTS : cross-sectional analysis among @number@ adults aged 40-64 years.
DESIGN : An epidemiological study of generational effects in three age cohorts.
DESIGN : An integrative literature review was completed using Garrard's ( @number@ ) Matrix Method.
DESIGN : An observational cohort study.
DESIGN : an observational cohort study ( ESTHER study ; 2000-present ) .
DESIGN : An observational cross-sectional study.
DESIGN : An observational longitudinal cohort study.
DESIGN : An observational , prospective , non-randomized , and unblinded study , with a minimum follow up of @number@ months.
DESIGN : An observational retrospective , comparative , multicentre epidemiological study.
DESIGN : An open , multicentre , randomised controlled trial.
DESIGN : An open , randomized trial.
DESIGN : A pilot randomized controlled trial.
DESIGN : A pilot study in groups of younger and older HIV-infected adults using objective measures of function.
DESIGN : A population-based cohort study.
DESIGN : A population-based cohort study using data from the Toledo Study for Healthy Aging ( TSHA ) .
DESIGN : A population-based cross-sectional study.
DESIGN : a population-based longitudinal study.
DESIGN : A population-based , prospective cohort of the OCTABAIX study ( @number@ inhabitants aged @number@ years at baseline ) .
DESIGN : A population-based prospective cohort study.
DESIGN : A population-based prospective cohort study established in Cache County , Utah in @number@
DESIGN : A population-based prospective substudy of the Osteoporotic Fractures in Men Study.
DESIGN : A post hoc pooled analysis of @number@ randomized , double-blind , parallel group clinical studies with results available as of @date@ .
DESIGN : A pragmatic , randomized , partially single-blind placebo-controlled study.
DESIGN : A pre / post implementation study design.
DESIGN : A propensity score-matched cohort analysis using retrospective data from @date@ , to @date@ .
DESIGN : a prospective cohort study.
DESIGN : A prospective cohort study.
DESIGN : A prospective cohort study.
DESIGN : A prospective cohort study.
DESIGN : A prospective cohort study.
DESIGN : A prospective cohort study.
DESIGN : A prospective cohort study.
DESIGN : A prospective cohort study with assessment of sleep disturbance and depression at baseline and across @number@ years of follow-up.
DESIGN : A prospective cohort study with @number@ yr of follow-up from @number@ to @number@
DESIGN : A prospective cross-sectional study of older Black and White patients presenting for outpatient cancer treatment.
DESIGN : A prospective longitudinal study.
DESIGN : A prospective longitudinal study was conducted.
DESIGN : A prospective , masked , observational cross-sectional study.
DESIGN : A prospective non-comparative multi-center study.
DESIGN : A prospective , observational study.
DESIGN : A prospective observational study.
DESIGN : A prospective observational study of a representative community-dwelling birth cohort ( born 1920-1921 ) by the Jerusalem Longitudinal Study ( 1990-2015 ) .
DESIGN : A prospective pilot , non-blinded , non-controlled study with case series evaluating a new treatment.
DESIGN : a prospective , population-based cohort study.
DESIGN : A prospective population-based cohort study.
DESIGN : A prospective , randomized , controlled , double-blind study.
DESIGN : A prospective randomized control trial.
DESIGN : A prospective study in an otologically screened population.
DESIGN : A qualitative descriptive study.
DESIGN : A qualitative design was used , incorporating focus groups and interviews in which participants discussed falls and falls prevention.
DESIGN : A qualitative study using semi-structured interviews.
DESIGN : A quasi-experimental design was used to assess change over @number@ months in healthy eating policy and practice in intervention and comparison child-care services.
DESIGN : A randomized double blind crossover trial.
DESIGN : A randomized , double-blind , placebo-controlled , cross-over design.
DESIGN : A randomized , double-blind , placebo-controlled trial.
DESIGN : A randomized , single-blind , crossover study of @number@ subsensory noise stimulation levels on @number@ days.
DESIGN : A repeated-measures design was used.
DESIGN : A retrospective cohort study.
DESIGN : A retrospective cohort study.
DESIGN : A retrospective cohort study.
DESIGN : A retrospective , cross-sectional , multicenter study performed from January to @date@ .
DESIGN : A retrospective cross-sectional study.
DESIGN : A retrospective matched cohort study of patients aged > 60 years admitted to a rehabilitation unit between @date@ and @date@ .
DESIGN : A retrospective research design was employed.
DESIGN : A retrospective research design was employed wherein hearing aid self-efficacy was the primary outcome.
DESIGN : A retrospective review of a paediatric cardiac surgery database.
DESIGN : A review of the existing literature on older people's nutritional needs and problems.
DESIGN : A scoping review of the literature and qualitative research methodology ( focus groups and structured interviews ) .
DESIGN : A semi-structured patient interview.
DESIGN : A seven-year prospective cohort study.
DESIGN : a single-blinded , parallel-group randomised controlled trial.
DESIGN : As part of a larger intervention study , data were collected from mid-life and older African Americans yearly for three years.
DESIGN : a survey quota sampling design was used to collect cross-cultural data.
DESIGN : A systematic review and meta-analysis of prospective and retrospective cohort studies were conducted.
DESIGN : A systematic review of databases and gray literature was conducted for recent CPGs.
DESIGN : A systematic review of primary research was undertaken and conducted according to the Preferred Reporting Items for Systematic Reviews.
DESIGN : a systematic review was performed by an initial electronic database search using three key search criteria.
DESIGN : A systematic search in PubMed , Embase , and PsycINFO was conducted to identify peer-reviewed articles evaluating adherence to ART in older adults.
DESIGN : A test-retest design was used in this observational measurement study.
DESIGN : A total of @number@ subjects participated in this study ( age range , 20-93 yrs ) .
DESIGN : A total of @number@ volunteers participated in this study.
DESIGN : A V-shaped performance evaluation matrix is applied to identify the top ten practices that are important but not easy to use or implement.
DESIGN : Baseline assessment of participants before randomization to study drug.
DESIGN : Baseline characteristics and clinical data from @number@ individuals who participated in the population based AGES-Reykjavik Study and gave their informed consent were used.
DESIGN : Baseline data from a randomized controlled trial.
DESIGN : Bayesian random-effects modeling and Winsorization of potential outliers were applied to develop a robust model for the majority of providers.
DESIGN : ' before ' and ' after ' study.
Design : Between-subjects design.
DESIGN : Blinded comparison.
DESIGN : Case-cohort study.
DESIGN : Case-control study.
DESIGN : Case-control study.
DESIGN : Case-control study.
DESIGN : Case control study of patients with DC compared with age- , gender- , and site-matched controls.
DESIGN : Case series.
DESIGN : Chart abstraction ; interviews.
DESIGN : Clinical audiometry and a questionnaire were performed at both time points in this longitudinal study.
DESIGN : Clinical study with biochemical and anthropometric measurements.
DESIGN : Cluster randomized trial.
DESIGN : Cohort.
DESIGN : Cohort analysis of primary care inpatient and death certificate data for individuals with hypertension.
DESIGN : cohort comparison.
DESIGN : Cohort-sequential design.
Design : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort study.
DESIGN : Cohort Study.
DESIGN : Cohort study SETTING : Primary care in a Veterans Affairs Medical Center.
DESIGN : Cohort study using data from the Minimum Data Set , Medicare claims , and the On-line Survey Certification of Automated Records.
DESIGN : Cohort study using multivariable regression to examine the association of protein intake % with each BMD , adjusting for covariates.
DESIGN : Cohort study with baseline medical examination performed between @number@ and @number@ and prospective follow-up for incident CHD performed until @number@
DESIGN : Cohort study with validation of linear , biphasic linear , differential , power , and quadratic equations undertaken in two additional cohorts.
DESIGN : Community-based 8-year longitudinal study.
DESIGN : Community-based cohort study.
DESIGN : Community-based epidemiological cohort study.
DESIGN : Community-based survey.
DESIGN : Comparative case-control cross-sectional study.
DESIGN : Comparative case series.
DESIGN : Comparative study.
DESIGN : Comparison of screening tools with criterion standard diagnostic interview.
DESIGN : Consecutive ECPBs from 2009-2011 were identified and billing data were used to determine the number of biopsies and IHC stains per case.
DESIGN : Consecutive patients with IDA were enrolled prospectively.
DESIGN : Correlations ; multiple regression models.
DESIGN : Cost-effectiveness study of a two-group randomized controlled trial involving @number@ patients-caregiver dyads randomized to intervention or wait-list control.
Design : Cross-sectional.
DESIGN : cross-sectional.
DESIGN : Cross sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional.
DESIGN : Cross-sectional analyses of a longitudinal study.
DESIGN : Cross-sectional analyses of data collected in 1992-96 from a longitudinal cohort.
DESIGN : Cross-sectional analyses of nationally representative data from the Collaborative Psychiatric Epidemiology Surveys ( 2001-2003 ) .
DESIGN : Cross-sectional analysis.
DESIGN : Cross-sectional analysis.
DESIGN : Cross-sectional analysis.
DESIGN : Cross-sectional analysis.
DESIGN : Cross-sectional analysis.
DESIGN : Cross-sectional analysis of a community-based cohort.
DESIGN : Cross-sectional analysis of a population-based sample.
DESIGN : Cross-sectional analysis of a population-based sample.
DESIGN : Cross-sectional analysis of baseline data from the Prospective Research In MEmory clinics ( PRIME ) study.
DESIGN : Cross-sectional analysis of baseline variables of a randomized controlled intervention trial.
DESIGN : Cross-sectional analysis of data.
DESIGN : Cross-sectional analysis of data from a longitudinal prospective study.
DESIGN : Cross-sectional analysis of data from the Baltimore Longitudinal Study of Aging ( BLSA ) .
DESIGN : Cross-sectional analysis of NIA's grant portfolio.
DESIGN : Cross-sectional analysis of @number@ community-dwelling men aged > or = 70 years.
DESIGN : Cross-sectional analysis of the Canadian Study of Health and Aging.
DESIGN : Cross-sectional analysis using baseline data from the Healthy Eating and Active Living in the Spirit ( HEALS ) intervention study.
DESIGN : Cross-sectional analysis , using observation cycle 2005 / 2006 of the population-based prospective cohort of the Longitudinal Aging Study Amsterdam.
DESIGN : Cross-sectional analytic study.
DESIGN : Cross-sectional and longitudinal analyses of a prospective cohort study.
DESIGN : Cross-sectional and longitudinal analyses with 4-year follow-up using data from the English Longitudinal Study of Ageing.
DESIGN : Cross-sectional and longitudinal analysis using existing data sets of a national survey.
DESIGN : Cross-sectional and longitudinal cohort study.
DESIGN : Cross-sectional and longitudinal , observational.
DESIGN : Cross-sectional brain Magnetic Resonance I ( MRI ) study.
DESIGN : Cross-sectional , case-control design.
DESIGN : Cross-sectional case / control study.
DESIGN : Cross-sectional cohort study.
DESIGN : Cross-sectional cohort study.
DESIGN : Cross-sectional , community-based study.
DESIGN : Cross-sectional community based study.
DESIGN : Cross-sectional , comparative design.
Design : Cross-sectional comparison.
DESIGN : Cross-sectional comparison.
DESIGN : Cross-sectional comparison of general medical and opioid dependent patients ( ODP , GMP ) .
DESIGN : Cross-sectional correlational study.
DESIGN : Cross-sectional correlational survey.
DESIGN : Cross sectional data-analyses.
DESIGN : Cross-sectional data analysis using a comprehensive questionnaire survey.
DESIGN : Cross-sectional data from the sixth wave of the Chinese Longitudinal Healthy Longevity Survey ( CLHLS ) conducted in @number@
DESIGN : Cross-sectional descriptive study.
DESIGN : Cross-sectional design.
DESIGN : cross-sectional epidemiological study.
DESIGN : Cross-sectional epidemiological study.
DESIGN : Cross-sectional examination of previous CE and past-month PTSD outcomes and depression in @number@ FRs.
DESIGN : Cross-sectional , experimental study.
DESIGN : Cross-sectional exploratory study.
DESIGN : Cross-sectional field study.
DESIGN : Cross-sectional longitudinal study.
DESIGN : Cross-sectional multicenter study.
DESIGN : Cross-sectional , nonrandomized study.
DESIGN : Cross-sectional observation.
DESIGN : Cross-sectional observational analysis of the relationship of dietary protein on body composition and physical performance.
DESIGN : cross-sectional observational study.
DESIGN : cross-sectional observational study.
DESIGN : Cross-sectional , observational study.
DESIGN : Cross-sectional , observational study.
DESIGN : Cross-sectional observational study.
DESIGN : Cross-sectional observational study.
DESIGN : Cross-sectional observational study.
DESIGN : Cross-sectional observational study.
DESIGN : Cross-sectional observational study.
DESIGN : Cross-sectional observational study.
DESIGN : Cross-sectional observational study.
DESIGN : Cross-sectional observational study among patients referred to the Geriatric Frailty Clinic.
DESIGN : Cross-sectional , population based cohort.
DESIGN : Cross-sectional population-based study.
DESIGN : Cross-sectional population-based study.
DESIGN : Cross-sectional population-based study.
DESIGN : Cross-sectional retrospective study.
DESIGN : Cross-sectional ; secondary analyses of the Eastern Townships Population Health Survey.
Design : cross-sectional study.
DESIGN : cross-sectional study.
DESIGN : Cross sectional study.
DESIGN : Cross sectional study.
DESIGN : Cross sectional study.
DESIGN : Cross sectional-study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study.
DESIGN : Cross-sectional study assessing associations between self-reported ADL and IADL difficulty and MMSE scores for race- and sex-specific groups.
DESIGN : Cross-sectional study based on retrospective data.
DESIGN : Cross-sectional study based on the @number@ National Health Interview Survey.
DESIGN : Cross-sectional study corresponding to the baseline assessment of the EPIDOS study.
DESIGN : Cross-sectional study ( FISTAC ) .
DESIGN : Cross-sectional study of baseline measures in the TTrials.
DESIGN : Cross-sectional study of individuals screened during intake for physicals and other routine procedures.
DESIGN : Cross-sectional study of secondary data.
DESIGN : Cross-sectional study of sepsis readmissions between @number@ and @number@ in the Medicare fee-for-service database.
DESIGN : Cross-sectional study SETTING : Magnetic resonance imaging ( MRI ) Research Center located in a university-affiliated hospital.
DESIGN : Cross-sectional study using a 54-item OHRQoL questionnaire.
DESIGN : Cross-sectional study using baseline ( 2013-2015 ) data from the ongoing Falls in Glaucoma Study ( FIGS ) .
DESIGN : Cross-sectional study using data from the @number@ Behavioral Risk Factor Surveillance System.
DESIGN : Cross-sectional study using data from two prospective cohorts.
DESIGN : Cross-sectional study with a consecutive clinical sample from an Alzheimer day-care hospital in France.
DESIGN : Cross-sectional study , with additional prospective data on falls and mortality.
DESIGN : cross-sectional study with data collected by telephone interview.
DESIGN : Cross-sectional survey.
DESIGN : Cross-sectional survey.
DESIGN : Cross-sectional survey.
DESIGN : Cross-sectional survey.
DESIGN : Cross-sectional survey.
DESIGN : Cross-sectional survey and in-depth interviews.
DESIGN : Cross-sectional survey data from @number@ to @number@ were analyzed.
DESIGN : Cross-sectional survey data from the longitudinal Chicago Health and Aging Project.
DESIGN : Cross-sectional survey of randomly selected households with children living in low-income diverse communities.
DESIGN : Cross-sectional survey of the community-dwelling civilian population in the United States.
DESIGN : Cross-sectional survey study.
DESIGN : Cross-sectional validation study.
DESIGN : Data analysis.
DESIGN : Data analysis of a longitudinal study of a representative , age stratified , population sample.
DESIGN : Data analysis of two randomized , controlled exercise trials.
DESIGN : Database and literature analysis.
DESIGN : Data collection from a nurse led community osteoporosis clinic.
DESIGN : Data from a cluster-randomized clinical trial and a cohort study.
DESIGN : Data from a cross-sectional study were used to evaluate diet quality assessed by mean adequacy ratio ( MAR ) .
DESIGN : Data from the baseline evaluation of @number@ residents aged ≥ @number@ years who enrolled in a comprehensive geriatric health examination survey was analyzed.
DESIGN : Data reported in this paper were obtained from published literature , reports , and gray literature available in the ASEAN countries.
DESIGN : Data were collected as part of the Beaver Dam Offspring Study , an epidemiological cohort study of aging.
DESIGN : Data were collected by mailed survey in @number@
DESIGN : Data were drawn from the Population Study of Chinese Elderly , a cross-sectional community-engaged study in the greater Chicago area.
DESIGN : Data were from the Beaver Dam Offspring Study , an epidemiological cohort study of aging.
DESIGN : Data were from the National Health Interview Survey @number@ and @number@
DESIGN : Data were pooled from six multicenter , randomized , placebo-controlled , double-blind , 6-month studies of memantine @number@ mg / day.
DESIGN : Derivation and validation study.
DESIGN : Descriptive and correlational study.
DESIGN : Descriptive , cross-sectional.
DESIGN : Descriptive , cross-sectional study.
DESIGN : Descriptive observational cross-sectional study.
DESIGN : Descriptive , reliability study.
DESIGN : Descriptive study using a structured questionnaire and convenience sampling.
DESIGN : Dietary habits were evaluated by assessing the diversity of food that was consumed.
DESIGN : Door-to-door cross-sectional surveys in the general population.
DESIGN : Double-blind , cluster-randomized controlled trial with 18-mo follow-up.
DESIGN : Double-blind , placebo controlled , randomised crossover study.
DESIGN : Double-blind , placebo-controlled randomized clinical trial.
DESIGN : Double-blind , randomized , placebo-controlled trial.
DESIGN : Double-blind , randomized , placebo-controlled trial.
DESIGN : Duplicate analysis methods were performed on separate data sets.
DESIGN : Each participant visited the laboratory seven times over @number@ to @number@ weeks.
Designed search strategies were used to search various databases for available studies.
Design , education , research , and policy all play roles in addressing these barriers to acceptance and use.
DESIGN : Eighty-four patients with multimorbidity and multiple-medication regimens completed three monthly panel questionnaires.
DESIGN : EMBASE and PubMed-NCBI were searched for relevant articles up to @date@ that identified potential interactions between foods or dietary patterns and CRC risk.
DESIGN : Epidemiologic , cross-sectional study.
Designer receptors exclusively activated by designer drugs ( DREADDs ) are novel and powerful tools to investigate discrete neuronal populations in the brain.
DESIGN : Evaluation performed at baseline , and @number@ and @number@ months postrandomization as part of a longitudinal trial.
DESIGN : Experimental cross-sectional design.
DESIGN : Experimental laboratory study.
DESIGN : Experimental research study.
DESIGN : Experimental study.
DESIGN : Experimental study.
DESIGN : Experimental study.
DESIGN : Experimental study.
DESIGN : Experimental study , cross-sectional analysis.
DESIGN : Expert panel survey.
DESIGN : Exploratory analysis from a cluster-randomized , investigator-masked , controlled trial.
DESIGN : Fifteen-month prospective study.
DESIGN : Fifteen subjects , skin types V and VI , between the ages of @number@ and @number@ were enrolled.
DESIGN : First , the localization of SIRT6 and proliferation cell nuclear antigen ( PCNA ) in human cartilages was examined by immunohistochemistry.
DESIGN : five-year prospective cohort study.
DESIGN : Focus group study.
DESIGN : For a blinded comparison , @number@ standardized @number@ × @number@ digital photographs of participants ' forearms were taken.
DESIGN : Forecasting study using the Cardiovascular Disease Policy Model , a Markov model.
DESIGN : For this secondary analysis , a cross-sectional study was performed.
DESIGN : Four-year prospective study.
DESIGN : Four-year prospective study.
DESIGN : FRADEA Study.
DESIGN : Gene ontology ( ie , gene product elucidation ) / meta-analysis.
DESIGN : General technology use was evaluated using a purposefully developed 25-item questionnaire.
DESIGN : Grounded theory guided the study design.
DESIGN : Grounded theory was used to analyze semi-structured interviews with @number@ older persons and their relatives.
DESIGN : High-resolution ( 99m ) Tc-HMPAO SPECT imaging during wakeful rest.
DESIGN : Historical prospective cohort study.
DESIGN : HIV infection is an independent risk factor for abnormal pulmonary function.
DESIGN : HSC per quarter was calculated for each individual.
DESIGN : Illuminative evaluation.
DESIGN : In 2002-2004 , we collected data from @number@ Guatemalan adults ( aged 25-42 y ) who were studied as children in 1969-1977.
DESIGN : In-depth semistructured interviews were completed in four countries with @number@ adults ( aged @number@ to @number@ years ) with hearing impairment.
Design : Individual participant data analysis.
DESIGN : Individual participant meta-analysis using data from @number@ cohorts participating in the CHANCES consortium.
Designing effective interventions to promote medication adherence in this patient group is therefore important.
Designing psychological interventions to improve proactive coping may help to improve quality of life at older ages.
Designing small molecules to block this interaction would lessen the effects of Aβ neurotoxicity.
DESIGN : Intervention study with one treatment group ( no control group ) .
DESIGN : In this observational study , sperm morphology profiles of patients were analyzed.
DESIGN : Investigator-initiated , prospective , multi-center , open-label study.
DESIGN : In vitro study.
DESIGN : It is a mixed method study.
DESIGN : It was a cluster randomised interventional studies.
DESIGN : It was a controlled study.
DESIGN : It was performed a systematic search for articles published between @number@ and @date@ in the MEDLINE / Pubmed , PsycINFO , and SCIELO.
DESIGN : Laboratory investigation.
DESIGN : Linear mixed models were used to estimate the group differences in longitudinal performance on measures of IADLs.
DESIGN : Literature review.
DESIGN : Longitudinal.
DESIGN : Longitudinal.
DESIGN : Longitudinal.
DESIGN : Longitudinal.
DESIGN : Longitudinal.
DESIGN : Longitudinal.
DESIGN : Longitudinal.
DESIGN : Longitudinal.
DESIGN : Longitudinal analyses of two nationally representative cohorts using semiparametric group-based models weighted and adjusted for baseline age.
DESIGN : Longitudinal analysis.
DESIGN : Longitudinal analysis of the association between gait speed and subsequent falls and analysis of gait speed decline as a predictor of future falls.
DESIGN : Longitudinal clinical-pathologic cohort study.
DESIGN : Longitudinal clinical trial.
DESIGN : Longitudinal cohort study.
DESIGN : Longitudinal cohort study.
DESIGN : Longitudinal cohort study ( Invecchiare in Chianti Study ) .
DESIGN : Longitudinal , cohort study of @number@ years.
DESIGN : Longitudinal cohort study using proportional hazards models to predict long-term nursing home residence and subdistribution models with death as a competing risk.
DESIGN : Longitudinal cohort study with @number@.3±0.3 years of follow-up.
DESIGN : Longitudinal cohort study with waves in @number@ @number@ @number@ and @number@
DESIGN : Longitudinal , community based.
DESIGN : Longitudinal data analysis.
DESIGN : Longitudinal , observational cohort study.
DESIGN : Longitudinal , observational cohort study.
DESIGN : Longitudinal , observational cohort study.
DESIGN : Longitudinal , observational study.
DESIGN : Longitudinal observational study ( the Helsinki Businessmen Study ) .
DESIGN : Longitudinal , population-based cohort study.
DESIGN : Longitudinal , population-based cohort study.
DESIGN : Longitudinal population-based cohort study.
DESIGN : Longitudinal , population-based study.
DESIGN : Longitudinal population-based study.
DESIGN : Longitudinal population based study on health with ageing.
DESIGN : Longitudinal population-based study with @number@.5- and 7-year of median follow-up.
DESIGN : Longitudinal , population-based , ' the @number@ British ' birth cohort study.
DESIGN : longitudinal population representative sample aged 65 + years.
DESIGN : Longitudinal postal survey.
DESIGN : Longitudinal study.
DESIGN : Longitudinal study.
DESIGN : Longitudinal study.
DESIGN : Longitudinal study.
DESIGN : Longitudinal study.
DESIGN : Longitudinal study of a cohort of elderly people followed up until almost all have died.
DESIGN : Longitudinal study of six data collections over a period of @number@ years.
DESIGN : Longitudinal study , part of the SABE Study ( Health , Wellbeing and Aging ) .
DESIGN : Longitudinal study with @number@ years follow-up.
DESIGN : Longitudinal survey study ; naturalistic ; 12-year follow-up.
DESIGN : Longitudinal twin study.
DESIGN : Markov model with single-year transitions.
DESIGN : Matched case-control comparison.
Design : MCM8 , MCM9 , and genes encoding DDR proteins that have been implicated in reproductive aging were sequenced among POI participants.
DESIGN : Measures of social relationships were obtained at baseline and associations with well-being over the following six years were analysed using mixed models.
DESIGN : Meta-analyses of studies on psychotropic drugs.
DESIGN / METHODOLOGY / APPROACH : This article developed the concepts of the health-care services in the form of a Medical Motorway.
DESIGN & METHODS : DNA samples were extracted from @number@ cell lines selected for giving specific amplifications with most BIOMED-2 PCR tubes.
DESIGN & METHODS : Li-heparin whole blood and plasma were used to perform analytical studies.
DESIGN : Midlife variables of @number@ twin individuals were based on postal questionnaires and registry records.
DESIGN : Mixed methods systematic review.
DESIGN : Moderated mediation model.
DESIGN : Multi-center , cross sectional observational study.
DESIGN : Multicenter cross-sectional study.
DESIGN : Multicenter , prospective cohort study.
DESIGN : Multicenter , prospective , double-masked clinical trial.
DESIGN : Multicenter , prospective , double-masked clinical trial.
DESIGN : Multicenter , prospective , double-masked , controlled clinical trial.
DESIGN : Multi-ethnic cross-sectional observational study.
DESIGN : Multi-site , cross sectional.
DESIGN : Multisite noninferiority prospective cohort study.
DESIGN : Multisite randomized clinical trial.
DESIGN : Multivariate Cox proportional hazard regression models were used to estimate HRs and @percent@ CIs for pancreatic cancer.
DESIGN : Nationally representative cross sectional study.
DESIGN : Nationally representative surveys of caregivers and older adults in the United States.
DESIGN : National register-based , population-based , matched case-control study.
DESIGN : National serial cross-sectional study.
DESIGN : Nationwide cross-sectional postal survey.
DESIGN : Nationwide population-based retrospective study using data entered into the Korean national health claims database from @number@ through @number@
DESIGN : Nested case-control genome-wide association study.
DESIGN : Non-randomised controlled study.
DESIGN : Nonrandomized controlled trial with pre- and posttraining tests in a training group and a control group.
DESIGN : @number@ subjects aged 45-65 years with Kellgren-Lawrence Scores @date@ in the study knee were selected.
DESIGN : NUTRIzione in EPAtologia ( NUTRIEPA ) is a population-based Double-Blind RCT.
DESIGN : Observational.
DESIGN : Observational , clinical study.
DESIGN : Observational cohort study.
DESIGN : Observational cohort study.
DESIGN : Observational cohort study.
DESIGN : Observational cohort study.
DESIGN : Observational cohort study.
DESIGN : Observational , cross-sectional study.
DESIGN : Observational , longitudinal study.
DESIGN : Observational , longitudinal study.
DESIGN : Observational longitudinal study.
DESIGN : Observational , prospective.
DESIGN : Observational , prospective cohort study with 6-month follow-up conducted from @number@ to @number@
DESIGN : observational study.
DESIGN : observational study.
DESIGN : Observational study.
DESIGN : Observational study.
DESIGN : Observational study.
DESIGN : Observational study , analysing prospective data.
DESIGN : Observational study , cross-sectional analyses.
DESIGN : Observational study with follow-up after @number@ months.
DESIGN : Observational study with longitudinal and cross-sectional components.
DESIGN : Observation of medication preparation and passes , chart review , interviews , and questionnaires.
DESIGN : One-day assessment of clinical practices.
DESIGN : One hundred eighty-four older Chinese inpatients were enrolled in this study from July to @date@ .
DESIGN : Online survey of a cross-sectional sample of @number@ women.
DESIGN : open labelled randomised controlled trial.
DESIGN : Open label , randomized , multicenter study.
DESIGN : Osteoporotic fractures were determined from medical records over 5-9 y of follow-up in men and women aged 66-96 y.
DESIGN : Overview of SRs and meta-analysis of comparative studies.
DESIGN : Parallel group randomised controlled trial ( RCT ) with @number@ participants in the intervention and @number@ participants in the control group.
DESIGN , PARTICIPANTS AND SETTING : This cross-sectional nutrition study was carried out in @number@
DESIGN : Participants completed a demographic and sleep quality questionnaire , followed by a blood draw.
DESIGN : Participants completed brief neuropsychological testing.
DESIGN : Participants included @number@ men and women ≥65 y of age who were residents of Cache County , UT , in @number@
DESIGN : Participants were a national sample of @number@ USA's adults of ages @number@ years and older.
DESIGN : Participants were from the Rush Memory and Aging Project , a large longitudinal clinical-pathologic study of aging.
DESIGN : Peripheral blood samples were collected from @number@ ART-naive , HIV-positive , and @number@ HIV-negative male participants , matched by age and race.
DESIGN : Phenomenology-based qualitative inquiry.
DESIGN : Physiology study.
DESIGN : Pilot prospective cohort study.
DESIGN : Pilot randomized controlled trial.
DESIGN : Pilot study involving surveying of participating long-term care sites regarding utility of recommendations and resident outcomes.
DESIGN : Pooled analysis.
DESIGN : Pooled data analyses of three prospective population-based cohorts , the Blue Mountains Eye Study , Beaver Dam Eye Study and Rotterdam Study.
DESIGN : Pooled data analysis of population-based cohorts.
DESIGN : Population-based and case-control design.
DESIGN : Population-based cohort of non-institutionalized adults with up to @number@ years of follow-up.
DESIGN : Population based cohort study.
DESIGN : Population-based cohort study.
DESIGN : Population-based cohort study.
DESIGN : Population-based cohort study.
DESIGN : Population-based cohort study.
DESIGN : Population-based cohort study.
DESIGN : Population-based cohort study ( PROOF study ) .
DESIGN : Population-based , cross-sectional study.
DESIGN : Population-based , cross-sectional study.
DESIGN : Population-based cross-sectional study.
DESIGN : Population-based cross-sectional study.
DESIGN : Population-based cross-sectional study.
DESIGN : Population-based longitudinal study.
DESIGN : Population-based longitudinal study.
DESIGN : Population-based longitudinal study.
DESIGN : Population-based longitudinal study with mean follow-up of @number@ years.
DESIGN : Population-based observational study.
DESIGN : Population-based , prospective cohort study.
DESIGN : Population-based prospective cohort study.
DESIGN : Population based retrospective study.
DESIGN : Population-based study.
DESIGN : Population-based study of thyrotoxicosis at disease onset.
DESIGN : Population-based survey.
DESIGN : Population-based surveys of caregivers and older adult care recipients in the United States in @number@
DESIGN : Pragmatic randomized , open label comparative trial of AChEI's currently available in the United States.
DESIGN : Pre- and post-trial.
DESIGN : Preclinical controlled in vivo laboratory study and retrospective cohort study.
DESIGN : Preliminary cohort study.
DESIGN : Pre-post intervention to test a GOC decision aid intervention for SDMs for persons with dementia in NHs.
DESIGN : Prevalence association study.
DESIGN : Prevalence-based , disease-specific cost-of-illness study.
DESIGN : Prevalence , sensitivity and specificity of Chinese version of HHIE-S were calculated.
DESIGN : prospective.
DESIGN : Prospective 5-year longitudinal study.
DESIGN : Prospective bicentric observational cohort study.
DESIGN : Prospective case series.
DESIGN : Prospective cohort.
DESIGN : Prospective cohort.
DESIGN : Prospective cohort.
DESIGN : Prospective cohort.
DESIGN : Prospective cohort analysis.
DESIGN : Prospective cohort of HIV-infected persons in care at eight US Veterans Health Administration sites.
DESIGN : Prospective cohort of individuals aged @number@ and older undergoing elective surgery , enrolled from @date@ to @date@ .
DESIGN : Prospective cohort of individuals aged @number@ and older undergoing structured PA intervention or health education.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective cohort study.
DESIGN : Prospective Cohort Study.
DESIGN : Prospective cohort study ( Canadian Task Force classification II-2 ) .
DESIGN : Prospective cohort study design.
DESIGN : Prospective cohort study ( mean follow-up : @number@.1±10.0 days ) .
DESIGN : Prospective cohort study nested within a randomized controlled trial of a paired sedation and ventilator weaning strategy.
DESIGN : Prospective cohort study ( Northern Manhattan Study ( NOMAS ) ) .
DESIGN : Prospective cohort study , with assessments at admission , three-months and one-year post-discharge.
DESIGN : Prospective cohort study with longitudinal analysis.
DESIGN : Prospective cohort study with @number@ years of follow-up.
DESIGN : Prospective cohort with longitudinal follow-up for mortality outcomes.
DESIGN : Prospective community-dwelling observational cohort study ( Health , Aging , and Body Composition study ) .
DESIGN : prospective , comparative , single-center , cross-sectional cohort study.
DESIGN : Prospective controlled study.
DESIGN : Prospective , cross-sectional study.
DESIGN : Prospective , double-blind , randomized and controlled , four-arm parallel design trial.
DESIGN : Prospective epidemiological cohort study.
DESIGN : Prospective follow-up of an age-homogenous representative community-dwelling cohort ( born 1920-21 ) in the Jerusalem Longitudinal Cohort Study ( 1990-2015 ) .
DESIGN : Prospective follow-up study.
DESIGN : Prospective Health , Aging and Body Composition Study.
DESIGN : Prospective investigation.
DESIGN : Prospective investigation.
DESIGN : Prospective longitudinal cohort study ( @number@ visits from 1994-2008 ) .
DESIGN : Prospective , longitudinal cohort study of aging.
DESIGN : Prospective , longitudinal , population-based cohort.
DESIGN : Prospective , longitudinal study.
DESIGN : Prospective , multicenter cohort study of men with or at risk for HIV.
DESIGN : Prospective multicenter study with a two-year follow-up of old patients participating in the SAFES cohort study.
DESIGN : Prospective multicentre cohort.
DESIGN : prospective , observational.
DESIGN : Prospective , observational cohort study.
DESIGN : Prospective , observational cohort study.
DESIGN : Prospective observational cohort study.
DESIGN : Prospective observational cohort study.
DESIGN : Prospective , observational cohort study with a baseline in-home assessment and 6-month telephone follow-up.
DESIGN : Prospective , observational , repeated measures investigation.
DESIGN : Prospective , observational study.
DESIGN : Prospective , observational study.
DESIGN : Prospective , observational study.
DESIGN : Prospective observational study.
DESIGN : Prospective observational study.
DESIGN : Prospective observational study.
DESIGN : Prospective observational study.
DESIGN : Prospective observational study.
DESIGN : Prospective observational study of prevalence.
DESIGN : Prospective observational study of the causes and course of physical disability.
DESIGN : Prospective polysomnographic investigation.
DESIGN : Prospective population-based cohort.
DESIGN : Prospective population-based cohort study.
DESIGN : Prospective population-based cohort study.
DESIGN : Prospective population-based cohort study.
DESIGN : Prospective population-based study.
DESIGN : Prospective population-based study.
DESIGN : Prospective , randomized controlled study.
DESIGN : Prospective , randomized crossover controlled study.
DESIGN : Prospective , randomized , double-blind , placebo-controlled clinical trial.
DESIGN : Prospective , secondary analysis from the Incidence of pNeumonia and related ConseqUences in nursing home Residents ( INCUR ) study with 1-year follow-up.
DESIGN : Prospective study.
DESIGN : Prospective study.
DESIGN : Prospective study.
DESIGN : Prospective study conducted from @number@ to @number@
DESIGN : Prospective study of @number@ individuals who underwent audiometric testing and were dementia free in @number@ to @number@
DESIGN : Prospective study with 1-year follow-up.
DESIGN : Prospective study with dental examinations approximately every @number@ years over @number@ years.
DESIGN : Prospective study with up to @number@ years of follow up.
DESIGN : Prospective , two-parallel group , repeated-measures study.
DESIGN : Qualitative content analysis was conducted on patients ' written responses to the question of what they thought had caused their PMR.
DESIGN : Qualitative cross-sectional study.
DESIGN : Qualitative descriptive study that uses focus group discussions for data collection ; @number@ employees in @number@ Swedish nursing homes participated.
DESIGN : Qualitative , multiple-case study design using semistructured interviews.
DESIGN : Qualitative research approach ( content analysis ) .
DESIGN : Quasi-experimental , with participants allocated to treatment group based on municipality of residence.
DESIGN : Questionnaire study.
DESIGN : Randomised controlled prospective study.
DESIGN : randomised , controlled ; single-blind parallel-group trial.
DESIGN : randomised controlled trial.
DESIGN : Randomised controlled trial.
DESIGN : randomised intervention.
DESIGN : Randomized block design and cross-sectional study.
DESIGN : Randomized clinical trial.
DESIGN : Randomized clinical trial ( Lifestyle Interventions and Independence for Elders Trial ) .
DESIGN : Randomized clinical trial with two intervention groups and one control group , and monitoring on readmission at @number@ and @number@ days after discharge.
Design : Randomized , controlled clinical trial.
DESIGN : Randomized controlled comparative efficacy trial.
DESIGN : Randomized , controlled trial.
DESIGN : Randomized , controlled trial.
DESIGN : Randomized , controlled trial.
DESIGN : Randomized controlled trial.
DESIGN : Randomized controlled trial.
DESIGN : Randomized controlled trial.
DESIGN : Randomized controlled trial.
DESIGN : Randomized controlled trial.
DESIGN : Randomized controlled trial.
DESIGN : Randomized controlled trial.
DESIGN : Randomized controlled trial.
DESIGN : Randomized controlled trial performed during March to @date@ .
DESIGN : Randomized controlled trials published in 2000-2012 were stepwise analyzed by statistically testing the representativeness of the gender ratio and examining reported gender differences.
DESIGN : Randomized controlled trial using within-church randomization.
DESIGN : Randomized controlled trial with repeated measures.
DESIGN : Randomized control trial.
DESIGN : Randomized cross-over.
DESIGN : Randomized , double-blinded , placebo-controlled study.
DESIGN : Randomized , double-blind , placebo-controlled clinical trial.
DESIGN : Randomized , double-blind , placebo-controlled maintenance trial.
DESIGN : Randomized , double-blind , placebo-controlled study.
DESIGN : Randomized , double-blind , placebo-controlled trial.
DESIGN : Randomized , double-blind , placebo-controlled trial of a multivitamin from @number@ to @date@ .
DESIGN : Randomized intervention study.
DESIGN : Randomized , placebo-controlled , double-blind trial.
DESIGN : Randomized repeated measures controlled trial.
DESIGN : Randomized single-blind controlled study.
DESIGN : RCT.
DESIGN : Repeated ANL measurements were presented diotically using earphones.
DESIGN : Repeated measures.
DESIGN : Repeated-measures cross-over design.
DESIGN : Repeated-measures design Subjects / Patients : Ten healthy subjects.
DESIGN : Reproductive biology.
DESIGN : Retrospective analysis.
DESIGN : Retrospective Analysis.
DESIGN : Retrospective analysis of @number@ cycles in @number@ poor responder patients.
DESIGN : Retrospective chart review.
DESIGN : Retrospective chart review.
DESIGN : Retrospective chart review.
DESIGN : Retrospective cohort.
DESIGN : Retrospective cohort analysis.
DESIGN : Retrospective cohort analysis.
DESIGN : Retrospective cohort analysis of Medicare data.
DESIGN : Retrospective cohort design.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study.
DESIGN : Retrospective cohort study ( Canadian Task Force classification II-2 ) .
DESIGN : Retrospective cohort study conducted using the Department of Veterans Affairs ( VA ) National Patient Care Database ( 2000-2011 ) .
DESIGN : Retrospective cohort study using data from a @percent@ national sample of Medicare beneficiaries.
DESIGN : Retrospective cohort study using hospice patient electronic medical record data.
DESIGN : Retrospective cohort study with longitudinal analysis.
DESIGN : Retrospective cross-sectional analysis.
DESIGN : Retrospective , cross-sectional observational study.
DESIGN : Retrospective , cross-sectional study.
DESIGN : Retrospective cross-sectional study.
DESIGN : Retrospective cross-sectional study.
DESIGN : Retrospective longitudinal study.
DESIGN : Retrospective longitudinal study.
DESIGN : Retrospective , observational.
DESIGN : Retrospective , observational case series.
DESIGN : Retrospective observational study.
DESIGN : Retrospective pooled analysis of previously published datasets.
DESIGN : Retrospective pooled analysis of prospectively collected data.
DESIGN : Retrospective review of magnetic resonance ( MR ) images.
DESIGN : Retrospective study.
DESIGN : Retrospective study.
DESIGN : Retrospective study.
DESIGN : Retrospective study of patients ' records between @date@ and @date@ .
DESIGN : Retrospective survival analysis with the application of the Cox proportional hazards model.
DESIGN : Review.
DESIGN : review of the @number@ RCTs included in the Cochrane systematic review of falls prevention interventions.
DESIGN : Review with retrospective cross-study analysis.
DESIGN : Rodgers's evolutionary method of concept analysis was used because of its applicability to concepts that are still evolving.
DESIGN , SAMPLE AND MEASUREMENTS : A cross-sectional survey was adopted.
DESIGN : Scoping review.
DESIGN : Scores were collected during the same testing session and were compared with other measures using a Pearson correlation.
DESIGN : Secondary analysis.
DESIGN : Secondary analysis.
DESIGN : Secondary analysis based on data collected during PREADViSE.
DESIGN : Secondary analysis of a cohort study.
Design : Secondary analysis of a multicentric prospective study.
DESIGN : Secondary analysis of an existing population based cohort study.
DESIGN : Secondary analysis of a randomized , controlled , parallel-group trial.
DESIGN : Secondary analysis of a randomized controlled trial.
DESIGN : Secondary analysis of baseline data from a population-based cohort study.
DESIGN : Secondary analysis of data collected through the Neurocognitive Outcomes of Depression Study.
DESIGN : Secondary analysis of data from a randomized controlled trial to reduce drinking in at-risk drinkers.
DESIGN : secondary analysis of data from The Irish LongituDinal study on Ageing ( TILDA ) .
DESIGN : Secondary analysis of data obtained as part of a longitudinal study of cognitive function in late-life depression.
DESIGN : Secondary analysis of nationally-representative , longitudinal health interview survey data ( Health and Retirement Study waves @number@ and @number@ ) .
DESIGN : Secondary analysis of prospectively collected data.
DESIGN : Secondary analysis of the @number@ National Health and Aging Trends Study ( NHATS ) .
DESIGN : Secondary analysis of the Survey of Health , Ageing and Retirement in Europe ( SHARE ) .
DESIGN : Secondary cross-sectional analysis.
DESIGN : Secondary data analysis.
DESIGN : Secondary data analysis.
DESIGN : Secondary data analysis of a pooled dataset.
DESIGN : Secondary data analysis of the Medicare Current Beneficiary Survey , a nationally representative survey of Medicare Beneficiaries.
DESIGN : Semi-structured , qualitative interviews.
DESIGN : Sequential mixed methods were used to explore the psychosocial issues nurses experienced throughout the course of this natural disaster and its lingering aftermath.
Design , Setting , and Participants : A longitudinal cohort study of aging from @number@ to @number@ in the National Alzheimer Coordinating Center.
DESIGN , SETTING , AND PARTICIPANTS : A population-based , longitudinal cohort study was conducted.
DESIGN , SETTING , AND PARTICIPANTS : A prospective longitudinal cohort study with up to @number@ years of follow-up was conducted.
DESIGN , SETTING , AND PARTICIPANTS : Biomarker analysis using neuroimaging and neuropsychological outcomes from the Alzheimer's Disease Neuroimaging Initiative.
Design , Setting , and Participants : Cross-sectional analyses using data from the Harvard Aging Brain Study of @number@ cognitively normal , community-dwelling participants.
DESIGN , SETTING , AND PARTICIPANTS : Cross-sectional observational study ( @date@ to @date@ ) at an academic medical center.
DESIGN , SETTING , AND PARTICIPANTS : Cross-sectional study using data of @number@ frail or prefrail Dutch elderly , aged @number@ years or older.
DESIGN , SETTING AND PARTICIPANTS : Data on @number@ patients who received TPN between January- @date@ were prospectively recorded and examined.
Design , Setting , and Participants : Double-blinded , placebo-controlled trial at @number@ academic medical centers in the United States.
DESIGN , SETTING , AND PARTICIPANTS : Eighteen candidate single-nucleotide polymorphisms from PD genome-wide association studies were evaluated in a joint clinicopathologic cohort.
DESIGN , SETTING , AND PARTICIPANTS : In vivo biochemical analyses were conducted after UV-A1 irradiation of normal human skin at an academic referral center.
DESIGN , SETTING , AND PARTICIPANTS : Longitudinal clinical-pathologic cohort study involving more than @number@ Catholic groups across the United States.
DESIGN , SETTING , AND PARTICIPANTS : Longitudinal observational study of brain atrophy in participants with early AD and cognitively normal controls.
DESIGN , SETTING AND PARTICIPANTS : @number@ Newcastle residents aged @number@ years or more were invited to participate.
DESIGN , SETTING , AND PARTICIPANTS : Observational longitudinal population-based Epidemiology of Hearing Loss Study.
Design , Setting , and Participants : Randomized clinical trial with @number@ × @number@ factorial design.
DESIGN , SETTING AND PARTICIPANTS : Subjects were recruited in Bordeaux ( France ) from the ongoing population-based 3C study.
DESIGN , SETTING AND PARTICIPANTS : The Blue Mountains Eye Study is a cohort study of community living participants aged @number@ + years.
DESIGN , SETTING , AND PARTICIPANTS : The Japanese Primary Prevention Project ( JPPP ) was a multicenter , open-label , randomized , parallel-group trial.
DESIGN , SETTING , AND PARTICIPANTS : This prospective , cohort study was conducted at a referral medical center.
DESIGN , SETTING , AND PARTICIPANTS : This retrospective cohort study was performed from @date@ , through @date@ ( follow-up , 5-7 years ) .
DESIGN , SETTING , AND PARTICIPANTS : This was a multicenter , parallel-group , unblinded , pragmatic clinical trial.
DESIGN , SETTING , AND PARTICIPANTS : This was a prospective , longitudinal outcomes study in @number@ men following RP at a university hospital.
DESIGN , SETTING , AND PARTICIPANTS : Two independent cohorts of the Longitudinal Aging Study Amsterdam were used.
DESIGN , SETTING , AND PARTICIPANTS : We conducted a population-based prospective study as a part of the Korean Longitudinal Study on Health and Aging.
DESIGN , SETTING AND PARTICIPANTS : We conducted a population-based prospective study as a part of the Korean Longitudinal Study on Health and Aging.
DESIGN , SETTING AND PATIENTS : @number@ patients older than @number@ were randomly selected in seven geriatric units at Toulouse University Hospital.
Design / Setting : A @number@.3-year prospective observational study of community-dwelling men participating in the European Male Ageing Study.
DESIGN , SETTING : A one year follow-up project among Danish nursing home residents.
DESIGN / SETTING : Dietary intervention of @number@ phases.
DESIGN , SETTING , PARTICIPANTS , AND EXPOSURE : Longitudinal clinicopathological cohort study at residences of participants in the Chicago , Illinois , metropolitan area.
DESIGN , SETTING , PARTICIPANTS , AND MEASUREMENTS : RBCLS was calculated from alveolar carbon monoxide concentrations measured by gas chromatography.
DESIGN , SETTING , PARTICIPANTS , & MEASUREMENTS : CHS enrolled community-dwelling adults age ≥65 years between 1989-1990 and 1992-1993.
DESIGN , SETTING , PARTICIPANTS , & MEASUREMENTS : Participants were recruited from March of @number@ through July of @number@
DESIGN , SETTING , PARTICIPANTS : This qualitative study comprised @number@ persons with AD and spousal caregivers of our trial.
Design / Setting : Prospective cohort study ( Osteoporosis Risk-Factor and Fracture-Prevention Study ) .
DESIGN & SETTING : Retrospective multicenter study.
DESIGN : Seven young subjects ( 19-32 years ) were matched with @number@ older subjects ( 50-63 years ) .
DESIGN : Single-arm Interventional Human Study.
DESIGN : Single-blind block-randomized controlled trial stratified according to clinic site and health literacy status.
DESIGN : Single-blind , cluster randomized trial.
DESIGN : Single-blinded randomized clinical trial.
DESIGN : Single-blinded , two group , cluster randomized trial.
DESIGN : Single blind , randomised , multicentre , parallel group comparative study.
DESIGN : Single-blind randomized clinical trial.
DESIGN : Single-subject design.
DESIGN : Six Cox proportional hazards models examined independent and additive relationships between physical activity , carotenoids , and all-cause mortality.
DESIGN : Six-year longitudinal study , part of the Sydney Memory and Ageing Study.
DESIGN : Small @number@ groups without random assignment.
Design specifications should include a wearable , non-stigmatising sensor at the user's wrist , with an emergency option in case of falling.
DESIGN : Spontaneous and voluntary physical examination.
DESIGN : SR and meta-analysis of comparative studies.
DESIGN : Structural equation modeling to examine mediators in a secondary analysis of a randomized trial with 4-month follow-up.
DESIGN : Studies were identified by a professional research librarian and content experts.
DESIGN : Study of death certificate data.
DESIGN : Subject identification via prospectively collected database.
DESIGN : Subjects underwent a night of sleep and @number@ h of sleep deprivation in a crossover counterbalanced design.
DESIGN : Substudy of a trial assessing the effect of @number@ months of CPAP on cardiovascular risk in type @number@ diabetes.
DESIGN : Survey of baseline dietary intake data of women and comparison to standard recommendations.
DESIGN : Survey of experts in MCC practice , research , and policy.
DESIGN : Survey of proprioception and balance differences between @number@ age groups.
DESIGN : Systematic overview of reviews.
DESIGN : Systematic review.
DESIGN : Systematic review.
DESIGN : Systematic review and meta-analysis.
DESIGN : Systematic review and meta-analysis.
DESIGN : Systematic review and random effect meta-analysis.
DESIGN : Systematic review of intervention and observational studies.
DESIGN : Systematic review of randomised clinical trials and pre-post intervention studies with meditative interventions for caregivers.
DESIGN : systematic review of randomised controlled trials.
DESIGN : Systematic review of the literature.
DESIGN : Systematic review of the published , peer-reviewed literature.
DESIGN : Taking a critical framing theory approach , thematic analysis was performed through coding relevant articles , abstracting and hierarchically categorising themes.
DESIGN : Taqman polymerase chain reaction ( @number@ index cases ) or single-nucleotide polymorphism genome-wide genotyping ( @number@ index cases ) .
DESIGN : Telephone and Web-based surveys.
DESIGN : The AIDS Clinical Trials Group Longitudinal Linked Randomized Trials was a prospective cohort study of HIV-infected individuals originally enrolled in randomized ART trials.
DESIGN : The analyses were conducted in a population-based , prospective cohort of the Longitudinal Aging Study Amsterdam.
Design : The ARNOGENE study was designed to prospectively follow a cohort of hemodialysis patients for @number@ years without specific intervention.
DESIGN : The current trial was a descriptive , cross-sectional study.
DESIGN : The data were collected in direct interviews.
DESIGN : The design used is a population-based cohort study.
DESIGN : The design was a population-based retrospective cohort study.
DESIGN : The fixed- or random-effect model was selected based on heterogeneity.
DESIGN : The Health , Aging , and Body Composition ( Health ABC ) Study is a longitudinal cohort study of @number@ community-dwelling older adults.
DESIGN : The Health , Aging , and Body Composition Study is a prospective cohort study of @number@ older adults.
DESIGN : The Invecchiare in Chianti ( InCHIANTI ) Study , a cohort study with 9-year follow-up.
DESIGN : the Leiden 85-plus Study ( 1997-2004 ) is an observational prospective cohort study with @number@ years of follow-up.
DESIGN : The Lifestyle Interventions and Independence for Elders ( LIFE ) was a multi-centered , single-blind randomized trial of older adults.
DESIGN : The Lothian Birth Cohort of @number@ took part in the Scottish Mental Survey of @number@ providing a measure of IQ at age @number@
DESIGN : The New England Registry for PDB ( NRPD ) is a voluntary registry with a questionnaire linked to a radiographic database.
DESIGN : The @number@ baseline and @number@ follow-up of the Cork and Kerry Diabetes and Heart Disease Study.
DESIGN : The PAQUID prospective cohort on brain and functional ageing.
DESIGN : The Predictors Study measured changes in BPSD , cognition , and dependence every @number@ months in patients with AD.
DESIGN : The present study applied a descriptive design.
DESIGN : The present study was conducted using a cross-sectional study design.
Design • The research team has summarized more than @number@ peer-reviewed reports.
DESIGN : The study sample consisted of @number@ independently living people aged 60-84 years.
DESIGN : The study's design was a retrospective chart review.
DESIGN : The study used a randomised , double-blind , placebo-controlled design.
DESIGN : The study used a randomised , double-blind , placebo-controlled design.
DESIGN : The study was explorative in nature and used a qualitative approach.
DESIGN : The study was randomised and double blinded.
DESIGN : the Survey of Health , Ageing and Retirement in Europe ( SHARE ) .
DESIGN : Thirty post-menopausal female patients with BMS ( @number@.0±5.0 years ) were included.
DESIGN : This article retrospectively examines the possible association of traditional cardiovascular risk factors with CAD in very elderly people aged > 90 years.
DESIGN : This cross-sectional study was carried out from @date@ - @date@ .
DESIGN : This is a clinical , prospective , randomized , controlled , one-center intervention study.
DESIGN : This is a cross-sectional analysis in the Structure of the Aging Men's Bones cohort.
DESIGN : This is a cross-sectional observational study of cognitive activities and neurocognitive function.
DESIGN : This is a cross sectional study.
DESIGN : This is a cross-sectional study.
Design : This is a longitudinal study over a 2-year period.
DESIGN : This is a meta-analysis of randomized double-blind placebo-controlled clinical trials.
Design : This is a methodological study.
DESIGN : this is a prospective observational study.
DESIGN : This is a prospective observational study.
DESIGN : This is a retrospective cohort study that used @number@ years of Medicaid enrollment and fee-for-service claims data.
DESIGN : This paper was derived from qualitative data gathered during a larger multimethod longitudinal study.
DESIGN : This prospective study with a one-year follow-up included @number@ hospitalized patients aged @number@ years and older.
DESIGN : This qualitative study employed purposive sampling.
DESIGN : This review used Cochrane diagnostic test accuracy procedures.
DESIGN : This study employed a randomized , placebo-controlled double-blind trial.
DESIGN : This study is an observational cohort study.
DESIGN : This study used an exploratory qualitative design involving personal interviews with geriatric nurse aides.
DESIGN : This study utilized an older adult group and younger adult group to compare performance on an electrophysiological and behavioral gap detection procedure.
DESIGN : This study was a cross-sectional , correlational study with data collected from @number@ women with type @number@ diabetes.
DESIGN : This study was conducted using a cross-sectional study design.
DESIGN : This study was conducted using a randomized , crossover design.
Design : This study was cross-sectional in design.
DESIGN : This was a cross-sectional analysis.
Design : This was a cross-sectional study.
DESIGN : This was a cross-sectional study.
DESIGN : This was a cross-sectional study.
DESIGN : This was a cross-sectional study conducted in an academic hospital.
DESIGN : This was a cross-sectional study including @number@ HIV-infected patients , aged 45-65 years , on ART for more than @number@ months.
DESIGN : This was a cross-sectional study using the Swedish version of the Clinical Learning Environment and Nurse Teacher evaluation scale.
DESIGN : This was a longitudinal analysis of data from the nationally representative Health and Retirement Study administered in @number@ with follow-up through @number@
DESIGN : This was a longitudinal observational study.
DESIGN : This was an observational cohort study in which total diet scores , reflecting adherence to dietary guidelines , were determined.
Design : This was an observational , cross-sectional study.
DESIGN : This was an observational , cross-sectional study.
DESIGN : This was an observational , cross-sectional study.
Design This was a parallel , two-arm , single-centre trial.
DESIGN : This was a population-based cohort study.
DESIGN : This was a population-based cohort study ( ESTHER study , baseline 2000-2002 ) .
DESIGN : This was a prospective cohort study.
DESIGN : This was a prospective , observational cohort study.
DESIGN : This was a prospective observational cohort study.
DESIGN : This was a qualitative study using focus group interviews.
DESIGN : This was a randomized and controlled trial with three parallel groups.
DESIGN : This was a randomized controlled design.
DESIGN : This was a randomized controlled trial.
DESIGN : This was a randomized double-blind , parallel , placebo-controlled trial.
DESIGN : This was a randomized , double-blind , placebo-controlled trial of protein supplementation daily for @number@ months.
DESIGN : This was a retrospective cohort study.
DESIGN : This was a retrospective cohort study.
Design : This was a retrospective cohort study that was followed up for ∼5 years.
DESIGN : This was a single-blind , randomized , placebo-controlled study.
DESIGN : Three different investigations were performed to evaluate the complex 3-dimensional changes during the perioral aging process.
DESIGN : Three longitudinal , population-based cohort studies.
DESIGN : Three-year nonprescriptive , observational study examining relationships between predictors and outcome variables in patients with dementia.
DESIGN : Trained staff collected demographic information , height , weight and @number@ h dietary recalls between @number@ and @number@
DESIGN : Transcriptional regulation was assessed by chromatin immunoprecipitation , promoter mutation and luciferase reporter assays.
DESIGN : transversal study.
DESIGN : Transversal study.
DESIGN : Trend analysis.
DESIGN : Trend analysis using data from the Medicare Current Beneficiary Survey , a nationally representative survey of Medicare enrollees , from @number@ to @number@
DESIGN : Twenty-five-year population-based cohort study.
DESIGN : Twenty-four-year longitudinal study.
DESIGN : Twenty-three-month retrospective analysis.
DESIGN : Two-arm , single-blind , randomized , controlled trial.
DESIGN : Two controlled observational studies.
DESIGN : Two hundred African American and White participants completed a baseline interview and up to six sets of three daily-diary interviews at monthly intervals.
DESIGN : Two-months , randomized , double-blind , placebo-controlled trial.
DESIGN : Two ongoing , prospective observational cohort studies of aging.
DESIGN : Two prospective cohort studies ( Personnes Agées QUID ( PAQUID ) , Aging Multidisciplinary Investigation ( AMI ) ) .
DESIGN : Two-wave survey design.
DESIGN : Two weeks randomized controlled trial.
DESIGN : Two year prospective study after an acute weight loss intervention.
DESIGN : Using multi-level modeling techniques , trajectories of marijuana and other illegal drug use are examined , with FEI as the primary independent variable.
DESIGN : U.S. population-based cross-sectional study.
DESIGN : Validation cohort.
DESIGN : Validation study.
DESIGN : Validation study.
DESIGN : VA National administrative data set and pharmacy records.
DESIGN : Vervet monkeys ( Chlorcebus aethiops sabaeus ) in stable and comparable social and nutritional environments were selected for evaluation.
DESIGN : Walking trials were collected for @number@ participants ( @number@ ± @number@ m , @number@ ± @number@ kg ) .
DESIGN : We analysed data concerning the gluteal adipose-tissue fatty acids ( analysed by GC ) from three studies.
DESIGN : We conducted a cross-sectional association study.
DESIGN : We conducted a cross-sectional data analysis using data from the 1999-2004 National Health and Nutrition Examination Survey ( NHANES ) .
DESIGN : We conducted a cross-sectional study in @number@ adult males and females , between @number@ and @number@ years.
DESIGN : We conducted an age-period-cohort analysis using data from the US Vital Statistics and the US Census covering the period 1968-2007.
DESIGN : We conducted a phase @number@ multicentre , tertiary setting , randomised , double-blind , placebo-controlled trial in patients with Rome III confirmed IBS.
DESIGN : We conducted a prospective cohort study.
DESIGN : We conducted a prospective cohort study among infants from Jimma , Ethiopia.
DESIGN : We conducted a retrospective chart-review study of consecutive inpatient admissions.
DESIGN : We conducted a systematic search in PubMed.
DESIGN : We employed a qualitative descriptive study using semistructured interviews.
Design : We measured salivary cortisol responses to @number@ challenging behavioral tasks.
DESIGN : We measured the frequency of transitions in patients with narcolepsy between sleep-wake states and to / from REM and NREM sleep stages.
DESIGN : We performed a cross-sectional analysis of a prospective cohort.
DESIGN : We performed a follow-up study using data from a group of @number@ year and older participants from a large Dutch clinical trial.
DESIGN : We performed a secondary data analysis of a longitudinal study of a representative , age-stratified , sample population.
DESIGN : We performed randomized , blinded N-of-1 trials with two 3-week um-PEA versus placebo comparisons , separated by 2-week washout periods.
DESIGN : We prospectively analyzed data on @number@ PHS participants who were free of DM at baseline ( 1997-2001 ) .
DESIGN : We studied @number@ men during thermoneutral conditions and mild non-shivering cold exposure ( CE ) .
DESIGN : We used an established and validated quantitative PCR technique to measure the mean LTL in a large sample of PCOS patients and controls.
DESIGN : We used cross-sectional data from NHANES 1999-2002.
DESIGN : we used data from the first and second waves of the Survey of Health , Ageing and Retirement in Europe.
DESIGN : We used data from the Veterans Aging Cohort Study ( VACS ) .
DESIGN We used genome-wide array data to identify ROHs ( > 1 megabase ) and conducted global burden and locus-specific ROH analyses.
DESIGN : we used quantitative methods to describe QoL , and qualitative methods to explore residents ' experiences of completing the measures.
DESIGN : We used self-administered questionnaire data from a 2005-2006 population-based survey ( n = @number@ ) .
DESIGN : We used the UK Biobank resource.
DESIGN : Within geographic areas comprising our target population , @number@ community organizations provided local space for conducting the study and program.
DESIGN : Within subjects repeated measures study.
DESIGN : Within three years , @number@ patient contacts were made in our ED.
DESIGN : With TECS , a trained ophthalmology technician is stationed in a primary care clinic away from the main hospital.
DESIGN : Younger listeners with normal hearing and older listeners with normal to near-normal hearing completed two tasks of F0 perception.
Desirable and excessive BMI reductions were not associated with poststroke mortality.
Desired outcomes were to increase nurses ' knowledge of self-management of chronic conditions and improve patient self-efficacy and clinical measures.
Desmin , the muscle-specific intermediate filament , is involved in myofibrillar myopathies , dilated cardiomyopathy and muscle wasting.
Despite abundant evidence that personality development continues in adulthood , little is known about the patterns and sources of personality development in old age.
Despite a decrease in the overall numbers of RSV-specific CD8 T cells during acute infection , their capacity to produce effector cytokines was not impaired.
Despite advances in device therapy and surgery , the mainstay of treatment for these disorders remains pharmacological.
Despite advances in their clinical and molecular characterizations , few therapeutic approaches exist for these diseases.
Despite advances in the treatment of major depression , one-third of depressed patients fail to respond to conventional antidepressant medication.
Despite advances , limitations remain when dealing with the obtuse cervical angle.
Despite advances , limitations remain when dealing with the obtuse cervicomental angle.
Despite a growing body of evidence , controversy still exists regarding absolute characteristics of the aging facial skeleton.
Despite a higher prevalence among older men , erectile dysfunction is not considered an inevitable part of aging.
Despite a large number of structurally unrelated substrates , Ub conjugation is remarkably selective.
Despite all implemented efforts , the patient died intraoperative as a result of cardiac arrest and its complications.
Despite all of this spending , the US receives average marks on outcomes and is not obtaining value in its healthcare.
Despite all these negative precedents , care is possible and develops itself in daily practice.
Despite a massive research effort to elucidate Alzheimer's disease ( AD ) in recent decades , effective treatment remains elusive.
Despite an aging Norwegian population , chronic lymphocytic leukemia ( CLL ) patients become younger at diagnosis.
Despite an increase of bleeding risk with aging , the efficacy of OAT in stroke prevention is maintained also in elderly patients.
Despite an older population with high comorbidity , length of stay decreased over @number@ years.
Despite an overall reduction in accuracy for older relative to younger adults , no behavioral age effect was observed as a function of emotional valence.
Despite a @number@ Å distance , binding of Ser-SA in the catalytic domain dramatically leverages the position of Insertion I in the tRNA binding domain.
Despite a number of histological analyses of talar microarchitecture , the effects of age and sex on talar microarchitecture changes remain poorly defined.
Despite a plethora of studies , the evidence regarding the environmental ( physical ) determinants of physical activity remains inconclusive.
Despite apparently minor impairments , many of these patients remain in rehabilitation for prolonged periods of time.
Despite a rapidly aging Asian American population , research has overlooked older people.
Despite a rapid overall decline in poverty among older people since the 1970s , poverty among elderly immigrants is persistently high in Canada.
Despite a recent decline in the U.S. prison population , the older prisoner population is growing rapidly.
Despite a reluctance to communicate openly about DRC , adult children and their parents share similar and significant concerns that merit increased attention.
Despite a small correlation between number of medical conditions and each neuropsychological variable , normative adjustments for number of medical conditions does not appear warranted.
Despite a vast amount of very promising basic research findings , these failed to successfully translate into the clinical practice so far.
Despite being an active regulator of gene expression , APPsβ did not rescue the lethality and neuromuscular synapse defects of APP and APLP2 double-KO animals.
Despite being of only minor abundance in the liver , it is involved in the clearance of > 25% of marketed drugs.
Despite being potentially more suitable for older adults , low-resistance exercise protocols have been less investigated.
Despite being recognized as a nosocomial pathogen , the precise modes of transmission of Stenotrophomonas maltophilia in health care settings are unknown.
Despite being the main users of medications , the elderly are largely underrepresented in clinical trials , especially if they have multimorbidity.
Despite being widely accepted potential techniques for fertility preservation , IVA and IVM of human primordial follicles to obtain fertilizable eggs remains far from reality.
Despite biochemical and epidemiological commonalities , obesity-migraine associations have been inconsistently observed.
Despite cell cycle arrest , confluent cells do not become senescent.
Despite compelling evidence linking protein carbonylation to numerous disorders , the underlying molecular mechanisms at the proteome remain to be identified.
Despite concomitant Alzheimer-like pathology , the neurodegenerative outcome in a DS brain deviates from common Alzheimer disease.
Despite conforming with disease-specific cardiovascular clinical practice guidelines , this polypharmacy predisposes many elderly individuals with cardiovascular disease to adverse drug events and non-adherence.
Despite conservative management , the elderly are hospitalized longer than their younger counterparts , have increased critical care needs , and have higher mortality.
Despite considerable progress , these issues are not easy to address , and important questions remain unresolved.
Despite consistent reports over many years of a greater prevalence of depression among women , mechanisms underlying the gender difference remain unclear.
Despite current efforts , black women exhibit greater risk for pregnancy complications and negative perinatal outcomes compared with white women.
Despite decades of intense research , the basic mechanisms still remain elusive.
Despite decades of research , mitochondrial epigenetics remains a controversial notion.
Despite decline over time , there were substantial between-country disparities in MSK mortality and its temporal trend.
Despite decreased potency , a few compounds still inhibit furin in the low nanomolar range , but display negligible efficacy in cells.
Despite differences in frailty , survival did not differ between groups ( p = 0.2 ) .
Despite differences in symptom patterns , broad manometric diagnoses and impairment of HRQOL in elderly patients with dysphagia are similar to those in younger counterparts.
Despite discrepancies in the proposed mechanism , and failed clinical trials , amyloid continues to be considered the cause of a degenerative cascade.
Despite displaying a differential distribution in GCB and ABC , both MNKs functionally complement each other to sustain cell survival.
Despite dominance of macrolide-resistant strains in Japan , clinical efficacy and bacterial eradication were achieved in @number@ of @number@ patients ( @percent@ ) .
Despite DTC patients have a favorable prognosis , aggressive disease is more frequently observed in the elderly showing a higher disease-specific mortality.
Despite efforts in tobacco control , the aging of the population and obesity epidemic will contribute toward the increasing incidence of cancer.
Despite efforts made to develop canine embryonic stem cells , success has been elusive.
Despite elevated protein , GRP78 and PERK mRNA was unchanged ; however , IRE1α mRNA was increased at @number@ h postexercise.
Despite enhancing cardiopulmonary and muscular fitness , the effect of hypoxic exercise training ( HE ) on hemorheological regulation remains unclear.
Despite evidence that many nursing home residents ' pain is poorly managed , reasons for this poor management remain unanswered.
Despite extensive experimental studies , researchers have not successfully characterized the nucleus ensemble , the starting point for rapid fibril formation.
Despite extensive literature on falls among seniors , little is known about gender-specific risk factors.
Despite extensive research into the neurophysiological correlates of retrieval mode , as of yet , relatively little is known about its functional significance.
Despite extensive research , oxidative stress-triggered regulation of proteasome complexes remains poorly defined.
Despite extensive research , the pathogenesis of neurodegenerative Alzheimer's disease ( AD ) still eludes our comprehension.
Despite extensive treatment options in patients with skin of color , there is a paucity of well-designed studies performed on this patient population.
Despite functional improvement , klotho level remains unchanged during the rehabilitation program.
Despite gender differences in facial anatomy and behavior , few studies have examined the role of gender in cosmetic procedures.
Despite general changes of outcome-related ERPs in healthy aging , older subjects show evidence of preserved effects of expectancy on the processing of monetary feedback.
Despite great demand for therapeutic intervention , it is often the case that these diseases are insufficiently understood at the basic molecular level.
Despite greater experience in implantation and improved device sophistication , patients continue to face complications associated with hardware implantation and device malfunction.
Despite great impact on daily living , women seem to be reluctant to seek help from professionals or talk about the problem.
Despite growing interest in AL , limited research has been conducted on aging samples.
Despite growing recognition in health and care services of the necessity for client engagement , it is still not easily put into practice.
Despite guideline recommendations , sliding scale insulin remains commonplace in the LTC setting and data on basal insulin use are lacking.
Despite having lower fracture rates than women , men have worse fractures than women do.
Despite having no direct role in cognition , ventricular expansion co-occurs with volumetric loss in gray and white matter structures.
Despite heavy plaque load at @number@ months , the number of cervical motor neurons in 5xFAD mice is comparable to wild type littermates.
Despite higher pentosidine in black boys ( P = @number@ ) , arterial stiffness indices did not correlate with pentosidine in any group.
Despite high heritability estimates , a genetic etiology for most sporadic ALS remains elusive.
Despite immense experience , a number of controversies in this topic exist.
Despite improved clinical outcomes of diffuse large B-cell lymphoma , a certain proportion of patients still develop a primary refractory disease.
Despite improvements in animal experimentation , excessive poorly designed animal studies with inappropriate endpoints and inaccurate conclusions are being conducted.
Despite improvements in understanding the mechanisms that regulate normal lung development , BPD remains without therapies.
Despite increasing evidence for the benefits of implemented screening programs , such as screening colonoscopy , compliance is rather low.
Despite increasing evidence of major differences between rodent and human immune and neurological function , relatively few biomedical studies are performed with human cells.
Despite increasing frailty , the 30-day and 12-month rates of mortality fell significantly ( p = @number@ and @number@ respectively ) .
Despite increasing interest in age- and gender-related bone alterations , data on trabecular microstructure at the proximal tibia are scarce.
Despite increasing interest the last years , the choroid plexus still is a relatively understudied tissue in neuroscience.
Despite increasing life expectancy worldwide , less is known about the effects of cigarette smoking on older populations.
Despite initial interest in the use of phospholipids ( PLs ) for ARCD , in recent years there has been a hiatus in such research.
Despite innate spine instability some spines remain intact lifelong.
Despite intense interest in origins and magnitude of oxidative stress , ability to quantify oxidants has been limited because they are short lived.
Despite intense investigations , no effective therapy is available to halt the progression of PD.
Despite intense research efforts , effective disease-modifying therapies for this devastating disease remain elusive.
Despite intensive investigation , however , the mechanotransduction events that initiate the myogenic response and the signaling pathways involved remain uncertain.
Despite intensive investigations , mechanisms of liver cancer are not known.
Despite intensive investigations , mechanisms of the failure of HSC to differentiate are not known.
Despite intensive research , which has led to a better understanding of the pathology , there is no effective treatment for this disease.
Despite it attracting increasing attention worldwide , less is known about its prevalence in the Chinese population.
Despite its apparent simplicity , the nematode Caenorhabditis elegans has a high rating as a model in molecular and developmental biology and biomedical research.
Despite its clinical importance , sarcopenia remains under-recognized and poorly managed in routine clinical practice.
Despite its disastrous health effects , high prevalence , and enormous associated health care costs , osteoporosis lacked a universally accepted definition until @number@
Despite its ease of use , insulin pen use was very low , at @percent@.
Despite its favorable influence on body fat distribution , menopausal hormone therapy cannot be recommended as a treatment for central obesity in midlife women.
Despite its heritability of 25-32 % , the genetic background of longevity is as yet largely unexplained.
Despite its limitations the available literature provides useful guidance on how PGU design can optimize patient and staff safety and improve clinical outcomes.
Despite its limited utility , patients express concern over their risk and , in some instances , request testing.
Despite its potential benefits for reducing disease exacerbations and hospitalisations , HIT home monitoring is not always accepted by patients.
Despite its prevalence , no effective therapeutic approaches exist for DUA.
Despite its prevalence , there is currently no universally adopted definition of sarcopenia.
Despite its public acclaim , it helps few and fails many more.
Despite its role as the primary cause of significant morbidity and mortality associated with cardiovascular disease , the pathogenesis of essential hypertension remains largely unknown.
Despite its role on the assessment of global cognitive functioning , the specific cognitive components required for test performance are still unclear.
Despite its shortcomings , however , the model persists.
Despite its similarity to the Sirt1 activator resveratrol , the compound potently inhibited both , Sirt1 and Sirt3.
Despite large performance increases in the trained WM tasks , we observed neither transfer to untrained structurally dissimilar WM tasks nor far transfer to reasoning.
Despite limited data , biological therapies are a promising treatment modality for DDD that could impact our future management of low back pain.
Despite living in facilities staffed by health professionals , a considerable proportion of residents are transferred to hospital for management of acute deteriorations in health.
Despite loneliness is one of the main indicators of well-being , little attention has been paid to understanding loneliness among immigrant older adults.
Despite long-term , conceptually and theoretically refined discussions , the phenomenon of ageism still remains empirically under-developed.
Despite major insecticide-based vector control programs , dengue continues to be a major threat to public health in urban areas.
Despite many decades of investigation , the discrimination among the consequences of these different types of lesions is not clear.
Despite many studies , no reliable biomarkers have been found to assess TBI severity and predict recovery.
Despite medical progress , high morbidity and mortality rates have persisted in patients with end-stage renal disease ( ESRD ) .
Despite most of these herbs showing an effect on biological mechanisms related to the cardiovascular system , data on their clinical effects are lacking.
Despite mounting evidence for its efficacy and the increasing popularity , the safety of BFR exercise in relation to cardiac loads has not been established.
Despite much progress , mainly in genetics , its etiology remains obscure in ∼50% of cases.
Despite multiple effective medical and surgical treatment strategies for adults with Crohn's disease and ulcerative colitis , efficacy studies typically have excluded older subjects.
Despite multiple indirect effects , there were still significant unexplained effects of race on cognition that were not moderated by age group.
Despite nearly @number@ centuries since the first reports of MTS , relatively little is known about its etiology and pathogenesis.
Despite no changes in body mass , these data contribute to evidence for the anti-inflammatory effects of exercise.
Despite numerous efforts to intervene on this public health crisis , HIV infections continue to escalate , especially among young men.
Despite numerous empirical investigations , the field lacks a coherent account of the dynamic processes that occur over our lifespan.
Despite numerous neuropathological studies that assessed the relationship of cognitive decline with neuropathologic lesions , their correlation still remains unclear.
Despite numerous trials , the range of interpretation of these has resulted in differing treatment perspectives.
Despite performing the task in a similar manner , older adults showed greater impairments in delay-execute prospective remembering.
Despite persisting levels of underweight in some countries in the Asia-Pacific , overweight and obesity have become endemic for almost the entire region.
Despite population differences , age , low education and vascular risk factors were identified as key factors in all scoring systems.
Despite pressing needs , there are currently no FDA approved prosthetic valves available for use in the pediatric population.
Despite progress in pathophysiology mechanisms , the medical therapy for brain ischemia has not been satisfactory.
Despite providing more hours of care , caregivers of black stroke were more positive about their caregiver role than caregivers of white stroke survivors.
Despite rapid advances in our understanding of bvFTD , the disease is still under-recognized and commonly misdiagnosed.
Despite rapid increase in the use of microneedles in dermatology , there are few data about their safety.
Despite recent advances , the neurovascular coupling mechanisms mediating the functional hyperemia response in the retina remain unclear.
Despite recent developments and new treatments in ophthalmology there is nothing available to cure retinal degenerations like Retinitis Pigmentosa ( RP ) yet.
Despite recent important discoveries , the pathogenesis of Huntington disease is still not elucidated.
Despite recent insights into the molecular mechanisms of fibroblast aging , age-related changes of the skin barrier function have been understudied.
Despite relationship difficulties , these women coped effectively with breast cancer in various ways.
Despite replacing voriconazole with liposomal amphotericin B , the patient developed septic shock and died at POD @number@
Despite reporting positive explicit attitudes , young people revealed an implicit bias against the sexual lives of older adults.
Despite reports from numerous big cohorts , no single adult life factor , including smoking , accounts for this accelerated decline.
Despite reports of changes in smell , olfactory ability has not been objectively assessed in this group.
Despite selective depletion of VEGFR-2 overexpressing endothelial cells from the tumor vasculature , SLT-VEGF treatment did not affect tumor growth.
Despite sepsis being a life-threatening disease , targeted drugs that improve the therapy of affected patients are still lacking.
Despite several descriptions of morphologic and histologic age-related changes in the literature , no scientific well-supported model of the labial aging process is reported.
Despite several therapeutic options available to treat HFrEF , morbidity and mortality remain high.
Despite significant advances in diagnostic methods for AD , there is no single diagnostic method for AD with high accuracy.
Despite significant advances in the field , particularly regarding drug metabolism and elimination , a number of issues remain unsolved.
Despite significant improvements in therapeutics , the mortality associated with acute kidney injury ( AKI ) in elderly patients remains high.
Despite significantly decreased longitudinal prestretch with age , the biomechanical response of human abdominal aorta changes substantially depending on the initial axial stretch was used.
Despite significant mean performance differences , Multiple Indicators Multiple Causes ( MIMIC ) models suggested most differences were at the construct level.
Despite similar BSPs in all age groups after exercise , CSP was higher in the older age group.
Despite similar muscle strength for young and middle-aged adults , the capacity to modulate a spinal reflex pathway was reduced in middle-aged adults.
Despite similar weight loss , serum ACs increase with CR alone but not CR + EX.
Despite some challenges with current measurement methodologies for oral diseases , measurable specific oral health goals should be developed to advance global public health.
Despite some disagreement in the findings , a trend toward spinal stiffening with the increasing degeneration was observed in most studies.
Despite some minor differences , loneliness , within all three discourses , is given the meaning of being a problem that needs to be solved.
Despite some tissue-specific characteristics many kinds of cells , including stem / progenitor cells , can undergo senescence both in vitro and in vivo.
Despite specialist emergency care , mortality was high with up to @percent@ dying in hospital.
Despite strong hereditary components , most cases of colorectal cancer are sporadic and develop slowly over several years through the adenoma-carcinoma sequence.
Despite strong observational and experimental evidence , the molecular basis of the deletion process remains obscure.
Despite strong WMH heritability , few gene associations have been identified.
Despite substantial correlative evidence to support it , studies in the last five years have raised doubts over its importance.
Despite substantial risk of IFI , we cannot provide a stronger recommendation for these patients.
Despite successes in TB control , disparities in TB still exist in Michigan , particularly by race , age , and nativity.
Despite that Achilles enthesis is the more frequently affected , no systematic study on the risk factors associated to this enthesopathy has been yet performed.
Despite that , the neuropathic potential of these OPs remains unclear.
Despite the absence of clinically-defined LVH , there was a relationship ( r = 0.29 ; p = 0.01 ) between systolic BP and LVMI.
Despite the absence of such risk factors , a spontaneous reactivation of HBV replication occurred in two elderly patients with resolved or occult HBV infection.
Despite the accepted concept that denervation-reinnervation events lead to myofiber type grouping , the completeness of those conversions remains unknown.
Despite the animal data suggesting a relationship between anesthesia and neurotoxicity in the elderly , a definitive link remains elusive in humans.
Despite the apparent magnitude of this problem , little is known about rates of repeat admission to hospital as a result of adverse drug reactions.
Despite the apparent roles of CSCs in human cancers , the biology underlying their behaviors remains poorly understood.
Despite the apparent structural role of Prom1 in photoreceptors , its role in other cells of the retina is unknown.
Despite the availability of a wide range of antihypertensive agents , almost two-thirds of hypertensive patients have poorly controlled blood pressure ( BP ) .
Despite the availability of BPSD assessment tools , it is unknown what the current practice of monitoring of BPSD in RACFs.
Despite the availability of these programs , many patients and professionals are reluctant to engage in and complete therapy.
Despite the availability of urate-lowering therapies ( ULT ) , patients may either have contraindications to them or may not adequately respond.
Despite the available evidence about beta-blockers , this therapy is still less frequently used in elderly compared to younger patients.
Despite the behavioral differences observed , similar Abeta pathology was observed between Tg mice on the two genetic backgrounds.
Despite the beneficial effects of CR , its large-scale implementation is challenged by applicability issues as well as health concerns.
Despite the benefits associated with caregiving , caregiver stress can lead to negative physical and mental health consequences , or \ "caregiver burden \ ".
Despite the benefits of regular physical activity among older adults , physical activity rates are low in this population.
Despite the benefits of treatment for late-life depression , underutilization of mental health services by older adults and nonadherence to offered interventions exist.
Despite the broad initial set of potential explanatory variables , only five predictors were jointly selected for the best statistical model.
Despite the challenges at the clinician , organisational and trial levels , the CSNAT intervention led to an improvement in caregiver strain.
Despite the changing demographics of CRC patients and increasing prevalence of multiple comorbidities , surgery is increasingly performed in this complex aging population.
Despite the clinical significance of sarcopenia , the operational definition of sarcopenia and standardized intervention programs are still lacking.
Despite the common situation of walking on different sloped terrains , previous work on gait has focused on level terrain.
Despite the complexity , skin stem cell populations are well defined , experimentally tractable , and exhibit prominent daily cell proliferation cycles.
Despite the considerable amount of resources in clinical medicine spent on elderly patients , accurate reference intervals for the elderly are rarely available.
Despite the critical role of E-cadherin in cancer progression , little is known about proteome alterations linked with its down-regulation.
Despite the decline in the age-standardized incidence , the absolute number of hip fractures increased owing to the aging population.
Despite the decrease of driving performance with distraction , participants estimated their driving performance during distraction as good.
Despite the differences between the static and dynamic approaches , a key consideration for both is the sensitivity of the models to the input parameters.
Despite the differences in transcriptome between climacteric and young ooplasts , gene expression profiles of SCNT blastocysts were very similar.
Despite the elevated PL content , the composition of PL in the lungs of the Npc1 ( - / - ) mice was unchanged.
Despite the encouraging results , it is difficult to establish a correlation between strength training and the improvements made.
Despite the extensive literature on disasters and evacuation , a significant question regarding evacuation and older adults has not been addressed.
Despite the extensive molecular research being carried out to understand the pathogenesis of canities , there is paucity of effective evidence-based treatment options.
Despite the fact that Alzheimer's disease was identified more than @number@ years ago , its cause remains elusive.
Despite the fact that these age-related changes in manual aiming have been observed consistently , the underlying mechanism remains speculative.
Despite the fewest complications , mitral valve operation had the highest total costs ( p < @number@ ) .
Despite the fundamental roles of SIRT6 in physiology and disease , only a handful of molecular and functional interactions of SIRT6 have been reported.
Despite the growing appreciation of these factors , however , little attention has been paid to the ethical and social implications of their interactions.
Despite the growing burden of cancer worldwide , it continues to receive low priority in Africa , across the continent and specifically in Sudan.
Despite the guidelines there is little evidence of a population-based change in physical activity.
Despite the high prevalence of asthma in the elderly , its development , diagnosis , and treatment are under-researched.
Despite the high prevalence of VCI , the general public awareness is limited.
Despite the high prevalence , osteoporosis remains largely undiagnosed and undertreated.
Despite the importance of HFpEF , there are numerous major gaps in our understanding of its pathophysiology and management.
Despite the importance of personal relationships to their health and well-being , changes in family structure have resulted in a lower frequency of intergenerational interactions.
Despite the importance of progerin and prelamin A in accelerated aging , the underlying molecular mechanisms remain largely unknown.
Despite the importance of this process , there is a lack of detailed structural information explaining the effects of deamidation on the structure of proteins.
Despite the importance to human reproductive health , the events precipitating female age-related meiotic errors are poorly understood.
Despite the important role age plays in medicine , it is too often considered only casually when considering mouse models.
Despite the increased disease burden in elderly patients , there is still a great uncertainty regarding \ "how to manage \ " BC in aging-population.
Despite the increase in p53 levels , p53 activity was inhibited in the presence of TRIM25.
Despite the increasing burden of chronic obstructive pulmonary disease in older people , underdiagnosis and undertreatment in this age group are still common problems.
Despite the increasing mortality in each successive wave , the @percent@ submaximal limit never exceeded @number@
Despite the interest shown in the concept of social participation over the last decade , there is no agreement on its definition and underlying dimensions.
Despite their broad availability , some patients are unwilling to undergo injectables and would benefit from an effective topical option.
Despite their critical function , the handful of proteins expressed by the mitochondrial genome is insufficient to maintain mitochondrial structure or activity.
Despite their early Aβ buildup , ape brains have not shown evidence dystrophic neurites near plaques.
Despite their effectiveness in reducing tumor recurrence , aromatase inhibitors have adverse effects on the cardiovascular system and increase osteoporosis and bone fractures.
Despite their frequency , the optimal treatment of these fractures remains controversial.
Despite their greater apparent adverse reaction to the drug , adolescents had significantly lower plasma PRX than adults at day @number@ of treatment.
Despite their importance for general health , emotion-related factors have rarely been considered in the etiology of late-life insomnia.
Despite their language impairment participants managed to position and reposition themselves and others by assistance of the trained facilitator.
Despite their memory impairment , older schizophrenia patients were able to assess the material accurately.
Despite their morphological and pathophysiological differences , intrinsic and extrinsic ageing share several molecular similarities.
Despite their negative perceptions of the task , they were willing to take on the responsibility of becoming a primary caregiver in the future.
Despite their potential as a sensitive measure of ventricular performance , tissue Doppler velocities vary with normal aging.
Despite their prominence , these concepts remain difficult to encapsulate , with multiple definitions and frameworks emerging over the past few decades.
Despite their worldwide prevalence , related literature remains scarce.
Despite the known benefits of physical activity participation , many people in the United States remain inactive.
Despite the lack of available treatment modalities , screening for NCI is recommended.
Despite the lack of international standardisation , some CgA assays are reliable.
Despite the large body of electrocardiographic , echocardiographic , and pathological data , mechanisms underlying this serious complication are not fully understood.
Despite the large body of knowledge regarding age-dependent epigenetic changes , there are few reports related to this topic in the cardiovascular field.
Despite the large number of published analytical methods for phenolic analyses , the values obtained may vary considerably.
Despite the large number of studies and reviews available , the evidence regarding the behavioral determinants of PA is still inconclusive.
Despite the limitations of most studies that indicated high prevalence rates , the results indicate the need for early detection of this syndrome.
Despite the limited data , some osteoporosis treatments have received approval to treat or prevent osteoporosis specifically in men.
Despite the limited impact as cost driver , population ageing remains a challenge for future health care services.
Despite the many efforts that are currently being made to improve the bioavailability of curcumin , brain concentration of curcumin remains low.
Despite the narrow age range of this community-based sample , age was correlated with all four diffusivity indices at the global level.
Despite the numerous studies of protein kinase CK2 , little progress has been made in understanding its function in chondrocyte death.
Despite the overall feeling that they have aged successfully , the respondent trans-lesbian population harbors significant fears about later life.
Despite the paucity of work , current results suggest that parameters beyond speed could be helpful in identifying different categories of frailty.
Despite the potential consequences , SCI is often underreported and undetected.
Despite the prevalence of anxiety in later life , there are no published studies on treatment preferences of older adults for anxiety problems.
Despite the profound role of age in disease etiology , knowledge about the molecular mechanisms driving the process of aging in humans is limited.
Despite the progress made towards establishing causal links between genomic and epigenomic changes and aging , mechanisms underlying metabolic dysregulation and age-related phenotypes remain obscure.
Despite the psychosocial conditions and limitations intrinsic to older age , the quality of life and survival in elderly patients on hemodialysis is frequently acceptable.
Despite the rapid aging of the world's population , many countries are experiencing difficulty in recruiting nurses to work with older people.
Despite the rapid increase of the KA elderly population , data on mental health service utilization among KA elders are scarce.
Despite the recent advances in stem cell biology , our understanding of many aspects of RPCs in the eye remains limited.
Despite the regulation of telomerase activity , the alternative splicing of hTERT pre-mRNA may play a role in other cellular functions.
Despite the relatively small volume required , the upper periorbital aesthetics of the patients were successfully and dramatically transformed.
Despite the relative tolerability and safety of this procedure , associated complications and unnatural deaths are still unavoidable.
Despite the remarkable progress made during the last two decades , our understanding of the biology of aging remains incomplete.
Despite the rising incidence of asthma in people > 65 years of age , the diagnosis is frequently missed in this population.
Despite these advances , HIV-associated neurocognitive disorders ( HAND ) remain prevalent.
Despite these age-related difficulties , no study has yet investigated the possibility to improve ToM in older adults.
Despite these apparent costs , ELF was under positive selection : individuals with higher ELF had higher lifetime reproductive success.
Despite these behavioral observations , the exact mechanisms underlying these neuroplastic phenomena remain obscure.
Despite these challenges , we achieved a @percent@ response rate with a sample size of @number@ participants comprising @percent@ nonwhite.
Despite these changes , educational disparities in health remained largely unaffected.
Despite these changes , the majority of older adults are able to maintain a positive sense of self and remain resilient.
Despite these detrimental outcomes , population frequencies of APOE-ε4 are high.
Despite these effects , the emotional stress experience was intact in this group and identical to the control group.
Despite these findings , ambiguity remains about the contextual factors that affect the physical and mental well-being of African American women.
Despite these findings , there is a great paucity in research , practice , and policy dealing with this pervasive issue.
Despite these identified relationships , the impact of AGTR1 A1166C on white matter integrity and cognition is less clear in a healthy aging population.
Despite these implicated pathways , longevity may be a polygenic trait influenced by a complex interplay of multiple genes.
Despite these implications , the molecular regulation of RPE oxidative stress under normal and pathological conditions remains largely unknown.
Despite these issues , knowledge is expanding and evolving with new solutions to ongoing problems.
Despite these measures , the incidence of CHD is on the rise in developed countries.
Despite these merits , we argue that this definition of SE has some serious omissions that are important in capturing SE comprehensively.
Despite these new advances , mantle cell lymphoma remains an incurable disease , and further basic and clinical research is warranted.
Despite these social assets , older adults remain vulnerable to mistreatment.
Despite these studies , it is not yet possible to make dietary recommendations with regard to the types and amounts of flavonoids to be consumed.
Despite the severity of these disorders , there is no curative treatment for any of them.
Despite the short history of psychiatric epidemiology in Korea , recently , epidemiologic data regarding geriatric psychiatric problems has started to accumulate.
Despite the significant improvement in assisted reproductive technologies we do not have so many options to enhance endometrial receptivity.
Despite the significant improvement in the treatment of patients with CHF , mortality in recent years has improved slightly.
Despite the significant overlap in immunological phenotypes between normal aging and HIV infection , the IRP has never been evaluated in HIV-infected individuals.
Despite the tremendous amount of literature on TTC , cardiac sympathetic hyperactivity is the only thing known to be associated with pathogenesis.
Despite the use of novel skin substitutes and wound dressings , poorly vascularized wound niches impair wound repair.
Despite the variety of novel facial rejuvenation technologies available today , the reference standard for correction of the senescent jaw line and neck remains rhytidectomy.
Despite the wealth of tools for Infinium 450k analysis , the identification of the most biologically relevant DNA methylation changes is still challenging.
Despite the well-known impact of ageing on human hair growth , little is known about changes in hHF keratinocyte clonogenic potential with age.
Despite the widespread use of glucocorticoids ( GCs ) , their anti-inflammatory effects are not understood mechanistically.
Despite this and the high prevalence of AF , OAC prescription rates were low.
Despite this common belief , previous research suggests that the relationship between age and wisdom is weak and inconsistent.
Despite this conclusive evidence of efficacy , several studies have shown that ' real world ' use of AVK in patients with AF is suboptimal.
Despite this , current assessment and treatment of pain in this patient group are inadequate.
Despite this decrease , a high proportion of older adults , including those with common chronic health conditions , drank in excess of current guidelines.
Despite this difference , many survive with aggressive resuscitation and goal-directed therapy.
Despite this different population context , BN prediction was highly reliable.
Despite this diversity , there is a consensus in what constitutes the diagnosis of MBL and its subtypes.
Despite this evidence , exercise is often neglected in patients with normal aging or neurologic disease progression.
Despite this evidence , several studies have indicated that , with advancing age , normal erections are not an absolute prerequisite to remain sexually active.
Despite this evidence , the screening of ED and hypogonadism in the diabetic population remains poorly implemented.
Despite this finding , @percent@ of the patients felt that the IPL-ALA-PDT-treated side of the face showed greater improvement than the IPL-treated side.
Despite this , general public knowledge about vascular surgery appears low.
Despite this high incidence of breast cancer among older women , social support for them is often inadequate.
Despite this high mortality , @percent@ patients still had an excellent response to treatment.
Despite this increase in variation , most of the studies on aging use group averages of immune phenotypes to model immune system behavior.
Despite this knowledge , treatment of dysglycemia in old subjects is usually overlooked by clinical practice.
Despite this , less is known regarding exercise training in the prevention and susceptibility of LDL subfraction oxidation , particularly in an aged population.
Despite this , little is known about the effect of pharmacological treatment for this patient group.
Despite this main effect of age , the effect of the type of learning was the same in the two groups.
Despite this , many elders report a high level of satisfaction.
Despite this , only 12 / 60 ( @percent@ ) were anticoagulated.
Despite this , phenotypic plasticity is not limitless.
Despite this plateau , the number of new cases in many countries will increase significantly in coming years due primarily to aging populations.
Despite this popularity , very little empirical research has been conducted to describe and understand medical travelers.
Despite this possible disparity , patients of minority ethnoracial groups often receive delayed diagnosis or inadequate treatment for dementia.
Despite this potential , little is known about current health promotion and prevention activities in occupational therapy community practice.
Despite this predictable demographic , drug trials have not kept pace with change and we now have significant evidence-practice gaps.
Despite this prevalence , hearing loss receives little attention in popular and political discourse , except in its connection to aging.
Despite this prevalence of growth disruption in the study sample , bone quality data conform to other documented populations with less growth disruption.
Despite this prevalence , such patients are often excluded from randomized trials or represent a minority of enrolled patients.
Despite this result , no difference was found at the protein levels analyzed by Western blot , thus suggesting a strong posttranscriptional modulation.
Despite this similarity , from genomic microarrays @number@ unique transcripts were differentially expressed after RL in old vs. only @number@ in young subjects.
Despite this , survival was not prolonged , most likely resulting from SMN mislocalization and depletion of gems in motor neurons of symptomatic mice.
Despite this symmetry , the mechanisms causing capacity increments in childhood may differ from those causing decline in old age.
Despite this , the average maternal age in the United States continues to rise.
Despite this , the exact mechanisms involved in the regulation of skeletal muscle glycogen metabolism and insulin signalling transduction remain elusive.
Despite this , the measurement of atrophy in routine clinical practice remains an unmet need.
Despite this , there are few studies in literature that quantify the upper limb skills in the elderly.
Despite this , there has been a steady decrease in the use of living-donor KT for pediatric recipients.
Despite this , there is growing evidence that the management of diabetes in NHs is suboptimal.
Despite this , there were no major differences in the predictors of subjective sleep across the age span.
Despite this , they are reluctant to utilize services to reduce their burden.
Despite this , within individuals , the decrease in molar sum of circulating BCAAs was the best metabolic predictor of improvement in IS.
Despite tremendous advances in cardiovascular care , morbidity and mortality for AHF remain high , consuming billions of health care dollars.
Despite typical POV architecture was preserved , signs of inflammation were found in glaucoma groups.
Despite using a large sample , the only GWAS published to date identified only one genome-wide significant locus in the 5q21 region.
Despite using a powerful paired twin design , we found no evidence for association of blood DNAmAge with cognitive abilities.
Despite variable economic conditions , the skin care market based on natural products continues to see strong growth.
Despite varying interpretations of existing data , we view the present results as consistent with previous findings.
Despite violating a century-old view in biology , this communication seems to play a role in transmission of environmental effects across generations.
Despite widespread community use , its associated factors are unclear.
Despite worse preoperative conditions , survival is not significantly lower after LVAD than after HTx at 2-year follow-up.
Destination memory seems to be particularly affected by aging , a deterioration that can be related to deficits in processing contextual features during encoding.
Destination recall in older adults was reliably predicted by with their context recall.
Detachment regarded mainly samples of surgical breast tissue and IHC procedures in which heat pretreatment was used.
Detailed analyses of the VA and VB TCR repertoires simultaneously showed a direct correlation between increasing age and narrowing of the TCR repertoire.
Detailed analysis of MRI revealed @percent@ smaller quadriceps muscles in the older than young individuals , while the other thigh muscles were only @percent@ smaller.
Detailed analysis of the FANCD2 gene structure indicated a proximal and distal polyadenylation site ( PAS ) , associated with @date@ and @date@ transcripts accordingly.
Detailed bioinformatics analyses and human homolog searches have identified specific biological processes and human-relevant signaling pathways in R15 that are affected during aging.
Detailed clinical data were collected with an identical protocol , and biochemical measurements were performed in a central laboratory.
Detailed clinical , imaging and genetic assessment was performed.
Detailed clinical , laboratory , and polysomnographic studies were obtained in all participants.
Detailed clinicopathologic correlations using twin longitudinal data and post-mortem examinations are mostly missing.
Detailed data collection included clinic data , a health and lifestyle survey , and blood sample collection.
Detailed data on reproductive history were obtained.
Detailed descriptions of patient attitudes may provide insight into mechanisms of disparity.
Detailed dose-response analyses allowing for non-linear associations nonetheless remain scarce in this field.
Detailed examination of work demands and musculoskeletal injuries amongst bridge employed adults could help define safer levels for less regular work activity.
Detailed growth and weight charts were used to calculate age at PHV , an objective assessment of pubertal timing.
Detailed identification of \ "protein trails \ " creates a more global picture of metabolic changes that occur in the elderly.
Detailed incidence estimates for these infections among older adults in the United Kingdom ( UK ) are lacking.
Detailed information on previous colonoscopy and potential confounding factors was collected by standardized personal interviews.
Detailed information was collected at recruitment including their TEG test results.
Detailed information were obtained from standardised personal interviews and medical records.
Detailed kinetic analysis revealed that TSA competes with the peptide substrate for inhibition , and this inhibition is unique to SIRT6 in the sirtuin family.
Detailed knowledge on pertussis specific immune mechanisms and their insufficiencies is important for understanding resurgence of pertussis in highly vaccinated populations.
Detailed measurements are limited by time , money and human resources , and self-reporting questionnaires represent a crude measure limited by subjectivity.
Detailed semi-structured interviews were conducted to explore experiences with , attitudes toward , and costs of healthcare.
Detailed socio-demographic , behavioral , physical and mental health information was also gathered and genotyping of five common ESR1 and ESR2 polymorphisms was also performed.
Details of National Health Service ( NHS ) usage will be collected to inform the economic analysis.
Details of the NAD World and its implications to age-associated metabolic diseases such as type @number@ diabetes will be discussed.
Details on statistical analysis are described in the text.
Detectability of both molecules up to 72h post-mortem was also assessed in rat brain.
Detectable blood concentrations were found with Zp in @number@ subjects at @number@ am and at @number@ pm.
Detected homozygous mutations and their cosegregation were confirmed by Sanger sequencing.
Detecting characteristics linked to suicide , therefore opening up the possibility of preventing tragic outcomes providing a proper treatment.
Detection and management of masked hypertension , a known strong predictor of cardiovascular risk , could improve prognosis for at-risk populations.
Detection and treatment rates in primary care remain low.
Detection is enhanced by PLA with a partner DDR marker at the DSB.
Detection of cognitive impairment in T2DM-patients identifies a vulnerable patient group that could benefit from tailored treatment and care.
Detection of dysfunctional and apoptotic cells plays an important role in clinical diagnosis and therapy.
Detection of early functional limitations may be clinically useful in assessing the future risk of developing cognitive impairment in cognitively normal older adults.
Detection of elder abuse risk is a critical issue because a lot of cases remain hidden.
Detection of ligature marks and their patterns may be fundamental for reconstructing events and supporting testimony of an aggression , sexual abuse , or maltreatment.
Detection of mcr-1-carrying bacteria in chicken samples was associated with colistin use and detection in human samples with exposure to mcr-1-positive chickens.
Detection of previously unknown AF during in-hospital ECG monitoring was obtained from medical records.
Detection rates of OP increase with age.
Detention order papers were scrutinized , the detaining practitioners were interviewed and case records were examined.
Detention rates ranged from @number@ to @number@ per @number@ over-65s.
Detergent-insoluble protein aggregates were isolated from Cancer-associated fibroblasts ( CAF ) remain a poorly characterized , heterogeneous cell population.
Deterioration accelerated after @number@ yr of age.
Deterioration in health should be acknowledged and requires proactive management.
Deterioration in localization performance was apparent even when only @number@ item had to be remembered , worsening disproportionately with increasing memory load.
Deterioration in temporal processing began after the fourth decade of life.
Deterioration of adult stem cells accounts for much of aging-associated compromised tissue maintenance.
Deterioration of locomotive ability causes falls or tumbles , which would be a threat to good health and longevity of aged people.
Deterioration of the skin's appearance occurs as a result of age and trauma , such as surgery , infections , and acne.
Determinants associated with sleep disturbances include depression , aging , nighttime cough and increased sputum volume.
Determinants of functional balance and mobility have rarely been investigated in geriatric wards.
Determinants of MP optical density ( MPOD ) and its relation to ARM were investigated.
Determinants of retirement transitions are examined using bivariate comparisons and multivariate logistic and multinomial logistic regression models.
Determinants of transitioning toward and away from sarcopenia were examined with logistic regression.
Determination of hemoglobin percentage was done employing modified cyanide method of Dacie and Lewis.
Determination of MUAC percentile may identify those least likely to demonstrate skeletal muscle deficit and improve patient selection for mass and function testing.
Determination of phosphorylated and basal amount of both proteins suggested higher mTOR activity in old murine tissue and senescent human fibroblasts.
Determination of senescent lymphocytes should be part of the diagnostic evaluation of children with refractory multilineage cytopenias.
Determination of telomere length in pancreatic ductal lesions may be valuable for accurate detection and risk assessment of pancreatic cancer.
Determination of the efficacy and ultimate balance between the two procedures requires further data on long-term stroke recurrence.
Determination of the MTHFR C677T polymorphism and of the mtDNA deletion was performed by real-time polymerase chain reaction analysis.
Determination of variant pathogenicity represents a major challenge in the era of high-throughput sequencing.
Determined by a combination of genetic and environmental factors , this process is highly individualized and poorly reflected in chronologic age.
Determined by pores , the experimental group had better results on weeks @number@ @number@ @number@ @number@ and @number@
Determining adapted consolidation and / or maintenance treatment to improve disease control in responding patients are the main challenges to be faced by future trials.
Determining how stressors influence health , well-being , and longevity in human and nonhuman primate populations are major foci within biological anthropology.
Determining its mitochondrial interactome , we have identified AGK as a constituent of the TIM22 complex in the mitochondrial inner membrane.
Determining the grade of renal impairment is important because of different approaches to treatment , monitoring , expected complications , and patient education.
Determining the presence and burden of cerebral amyloid angiopathy is particularly important when planning to start or restart anticoagulation after an intracerebral hemorrhage.
Determining the relative efficacy of eccentric exercise when compared with the more conventionally prescribed traditional resistance exercise will support evidence-based prescribing for the aging population.
Determining the risk of atrial fibrillation within the hypertensive population without ischemic vascular disease would aid in decision making on preventive approaches.
Determining the specific sites of this modification remains a challenge due to the low stoichiometry of 3NT modifications in biological samples.
Determining which ingredients to include can form the foundation for the successful treatment of each of the most common skin conditions.
Detoxification could occur at the expense of anti-oxidative defenses and whole body protein stores in elderly.
De-training for 6-weeks did not result in significant changes in any measure from post-training performance.
Detriments in QoL persisted during the observation period and affected particularly cancer survivors at younger ages ( < 50 years ) .
Developed around the principles of implementation and complexity science , the CCRC opened in @number@ as a clinical center with a secondary research focus.
Developed for home interviews , these biomeasures are readily applicable to other surveys.
Developing a patient-specific care plan and instituting close follow up is emphasized.
Developing a test that is independent of education and language barrier will probably be better.
Developing countries are underperforming in terms of coverage and they rely mostly on restrictive state controls to regulate prices and expenditure.
Developing environments responsive to the aspirations of older people has become a major concern for social and public policy.
Developing healthy habits at an early age can contribute to combating increasing child obesity rates.
Developing microwave systems for biomedical applications requires accurate dielectric properties of biological tissues for reliable modeling before prototyping and subject testing.
Developing novel compounds for any indication is a time , effort , and money consuming endeavor and most treatments never make it to market.
Developing readers often make anagrammatical errors ( e.g. misreading pirates as parties ) , suggesting they use letter position flexibly during word recognition.
Developing recommendations regarding snacking and meal frequency is extremely problematic for numerous reasons.
Developing strategies and health intervention methods to ameliorate this situation is paramount.
Developing therapeutics for indications in which reactive oxidant species are an important consideration presents some unique challenges.
Developing tools to support medication self-management to polymedicated elderly may contribute to increase their safety.
Developing truly MVB-specific markers would help to elucidate the roles of neuronal MVBs in intra- and intercellular signaling of normal and diseased neurons.
Developmental and individual differences differentiate seemingly similar processes of orienting to perceptually available representations and to representations held in VSTM.
Developmental changes in structural MRI measures have rarely been examined in relation to discrete neuropsychological functions.
Developmental changes of RBM thickness were accompanied by similar changes in epithelial height , supporting the close relationship between RBM and epithelium within the EMTU.
Developmental , clinical and educational implications of these findings are discussed.
Developmental considerations and clinical implications regarding the utility of the construct of pain catastrophizing across age groups are discussed.
Developmental Dynamics 246 : 359-367 , @number@ © @number@ Wiley Periodicals , Inc.
Developmental exposure to this neurotoxicant may contribute to cognitive decline and abnormal aging.
Developmentally , only expression of VEGF mRNA was increased with age in the entorhinal , and somatosensory cortex of wild type mice.
Developmentally programmed senescence is followed by macrophage infiltration , clearance of senescent cells , and tissue remodeling.
Developmental neuroimaging results have suggested a progression in focalization in functional activations from childhood to adulthood.
Developmental pathways that orchestrate the fleeting transition of endothelial cells into haematopoietic stem cells remain undefined.
Developmental programs for oogenesis also contribute to variation in aging-related reproductive declines among female vertebrates.
Developmental structural neuroimaging studies in humans have long described decreases in gray matter volume ( GMV ) and cortical thickness ( CT ) during adolescence.
Developmental trajectories of amygdalar and hippocampal volume were not associated with subclinical anxiety.
Development and dissemination of appropriate curricular material to address the public health and policy aspects of palliative care is needed to address this gap.
Development and integration of strategies to support older people's decision-making when in the ' grey zone' , with fluctuating cognitive capacities , needs further consideration.
Development and progression of atrial fibrosis is the hallmark of structural remodeling in AF and is considered the substrate for AF perpetuation.
Development and validation of a functional fitness test for community residing older adults.
Development does not take place in isolation and is often interrelated with close others such as marital partners.
Development of a better PET radioligand for α4β2-nAChR was a focus of substantial investigation that has been thoroughly reviewed ( up to @number@ ) previously.
Development of Alzheimer's disease in APOEε4 noncarriers may be unrelated to ApoE concentration.
Development of AMD has been recognized as contingent on environmental and genetic risk factors , the strongest being advanced age.
Development of an evidence-based approach to the management of ageing VWD patients is therefore necessary.
Development of a second malignancy is one of the most serious late effects in survivors of both childhood and adult-onset cancers.
Development of bone metabolism markers began about @number@ years ago.
Development of EAE requires infiltration of inflammatory cytokine-generating monocytes and macrophages , and auto-reactive T cells , into the CNS.
Development of effective preventive and treatment strategies for late-life dementia relies on a deep understanding of all the processes involved.
Development of effective treatment or new therapeutic strategies for ischemic stroke patients is therefore crucial.
Development of functional limitations , resulting from improper maintenance and restoration of various organ systems , ultimately leads to reduced health and independence.
Development of fungicidal cement spacers still continues and in vitro data show promising results of bioactive cements.
Development of hand preferences for unimanual manipulation of objects was explored in @number@ infants ( @number@ males ) tested monthly from @number@ to @number@ months.
Development of implant technology currently requires extensive non-clinical testing to demonstrate device performance.
Development of new instruments should be justified , and existing ones investigated for scale behaviour using appropriate methods.
Development of new memory tests requires experiments on animals and then clinical trials in humans.
Development of novel antiretrovirals and antiretroviral combinations with a low propensity for toxicity , drug-drug interactions and reliable pharmacology regardless of age is urgently needed.
Development of predictive neural markers could facilitate increased vigilance and prevention.
Development of pressure ulcers that is initially observed as deep tissue injury is multifactorial.
Development of shoulder stiffness during follow-up was significantly negatively correlated with a change in the cross-sectional area of the deep extensor muscles.
Development of the motor system lags behind that of the visual system and might delay some visual properties more closely linked to action.
Development of the Trust in Physician scale : a measure to assess interpersonal trust in patient-physician relationships.
Development or review of the model of care ( MOC ) may provide a possible solution to support efficiencies in service provision.
Developments in MRI acquisition , image processing and data modeling have been key to these advances.
Deviated endocrinological function is observed in both the elderly and young patients with DM.
Deviating distributions were observed in subjects with ' fetal ' PCA.
Deviation in these normal events can have severe consequences as observed in aging and neurodegeneration.
Deviations from the average young-adult network reflected underactivation of frontoparietal regions instead of overactivation of regions not activated by younger adults.
Deviations in redox pathways result in the development of various pathologies at cellular and organismal levels.
Deviations of the practiced sequence were introduced to assess motor reprogramming ability.
Device-detected steps were compared with manually counted steps.
Device related infection was detected in only @number@ patient with immunosuppressive therapy.
Devices and drugs that can be differentiated by producing improved patient outcomes would , therefore , be likely to win market share.
DEVICES : Different fractional laser machines , with different wavelengths , both ablative and non-ablative , are now available in India.
DEVICES : Different technologies such as lasers , Intense Pulsed Light ( IPL ) , and radiofrequency have been introduced.
DEVILated myofibers were also identified in elderly rat ( @number@ month ) and cadaveric human ( @number@ years ) muscles.
DEX exposed males at @number@ months had an approximate @percent@ reduction in nephron number compared to SAL , but no difference in cardiomyocyte number.
Dexterity impairments are well documented in older adults , though it is unclear how these influence touchscreen manipulation.
DFMO selectively blocked testosterone's effects on prostate , but did not affect testosterone's anabolic effects on muscle.
DF severity was evaluated using the Thylstrup-Fejerskov Index ( TFI ) .
D-galactose was used to mimic chronic pathological aging.
DHA accounts for @percent@ of the membrane phospholipid FA in the brain.
DHA also up-regulated the phosphorylation of p38 and ERK , and dramatically inhibited nuclear translocation of NF-κB-p65 in VSMCs.
DHA in plasma is normally positively associated with DHA intake.
DHA is a key nutritional n-3 PUFA and needs to be supplied by the human diet.
DHA is deemed to display anti-inflammatory properties and to reduce the risk of CVD.
DHA is found in significant amounts in the retinal and neuronal cell membranes due to its high fluidity.
DHA level varied more in AD than controls but the mean values were not significantly different.
DHA supplementation can reduce markers of inflammation.
DHAvD may be a useful candidate for preventing UV light-induced skin photoageing.
DHAvD regulates UVB-irradiated MMP expression by inhibiting ROS-mediated MAPK / NF-κB and AP-1 activation.
DHA was marginally correlated ( p = @number@ ) with total brain volume while EPA was less so ( p = @number@ ) .
DHEA and DHEA-S levels were compared between the groups using ANCOVA , controlling for age.
DHEA / DHEAS appear protective in asthma and allergy.
DHEA does not appear to routinely benefit measures of physical function or performance.
DHEA is one of the main adrenal hormones that progressively reduces its plasmatic levels from the beginning of ageing.
DHEA levels reduce with aging , while cortisol levels remain substantially unchanged , resulting in an overall increase in the cortisol : DHEA ratio.
DHEA may , thus , represent a first agent beneficially affecting aging ovarian environments.
DHEA modulates cardiovascular signalling pathways and exerts an anti-inflammatory , vasorelaxant and anti-remodelling effect.
DHEA over time also appears to objectively improve ovarian reserve.
DHEA replacement improved glucose tolerance in participants who had abnormal GT initially , reduced plasma triglycerides , and the inflammatory cytokines IL6 and TNFα.
DHEAS and testosterone have anti-obesity / anti-aging characteristics and also improve libido , vitality and immunity levels.
DHEA-S level in men and testosterone and estradiol levels in women were not related to mortality.
DHEAS stimulation significantly promoted the proliferation of CRPC cells when compared to that of LNCaP cells.
DHEAS was associated with men wanting more sex and with good morning penile rigidity.
DHF also protected the keratinocytes against hydrogen peroxide- and ultraviolet B-induced oxidative damage , while HO-1 , ERK and Akt inhibitors markedly suppressed DHF-mediated cytoprotection.
DHF cases attributable to vaccine-derived enhancement were fewer than DHF cases prevented by a vaccine with considerably high ( although not perfect ) seroconversion rates.
DHF markedly upregulated HO-1 mRNA and protein expression in human keratinocytes ( HaCaT cells ) , resulting in increased HO-1 activity.
DHF occurs mainly when an individual who has acquired antibodies to one serotype is inoculated with another serotype.
DHT treatment attenuated the effect caused by AD on GI morphometrics , APP expression and colon micro flora population.
\ "Diabesity \ " is a new term which refers to diabetes occurring in the context of obesity.
Diabetes afflicts hundreds of millions worldwide.
Diabetes also causes a further impairment of neurogenic relaxation in HCC and HPRA.
Diabetes also emerged as an independent risk factor ( OR = @number@ @percent@ CI = @number@ to @number@ ) .
Diabetes and elevated depressive symptoms are inversely associated with memory and executive function , but , individually , do not accelerate cognitive decline.
Diabetes and high cardiovascular risk were strong independent predictors of uncontrolled BP.
Diabetes and obesity were identified as risk factors in all cities.
Diabetes and osteoporosis are both common diseases with increasing prevalences in the aging population.
Diabetes and physical inactivity were associated with poor hypertension control.
Diabetes and time on dialysis substantially increase the risk for arterial calcification.
Diabetes , arthritis and depression were significantly related to earlier retirement.
Diabetes can cause peripheral nerve dysfunction , which might be one pathway through which diabetes leads to decreased physical function.
Diabetes can produce hippocampal lesions via both vascular and non-vascular pathologies and can reduce the threshold for hippocampal damage.
Diabetes cases and controls underwent fasting glucose testing ; CAO cases and controls underwent spirometry testing.
Diabetes clearly impaired PDE5 inhibitor-induced vasodilation of HPRA from ED patients.
Diabetes duration was longer in [ SLF & / or SLM ] ( p @number@ ) .
Diabetes educators are uniquely positioned to improve the health status of their patients by identifying persons who need referral for further evaluation of their hearing.
Diabetes educators have a responsibility to learn how to communicate better with their patients who have a hearing impairment.
Diabetes , falls , cataracts , renal insufficiency , and peripheral vascular disease were also associated with PrU development.
Diabetes , heavy drinking , heart failure , and age remained significantly associated with mortality in the multivariate Cox regression analysis.
Diabetes , hypertension , and advanced age are primary risk factors for acute kidney injury.
Diabetes , hypertension and atherosclerosis have become most common causes of kidney diseases.
Diabetes , hypertension , hyperuricemia , and high baseline eGFR were associated with a decline of eGFR.
Diabetes incidence was based on documented and / or self-reported diagnosis during follow-up.
Diabetes increases the risk for developing secondary complications such as nephropathy and cardiovascular disease , critical factors that dictate the survival rate of diabetes patients.
Diabetes in older persons represents significant medical , human , and socioeconomic burden.
Diabetes in the elderly is a growing public health problem , impacting both quality of life and autonomy.
Diabetes is a common condition in older people.
Diabetes is a condition of accelerated vascular aging.
Diabetes is a duration-dependent risk factor for cardiovascular events which influences outcomes differently from prior vascular disease.
Diabetes is an increasing epidemic ; hyperglycemia results from lack of insulin or inadequate insulin secretion following increases in insulin resistance.
Diabetes is an increasing problem in nursing homes and therefore an area where more knowledge among staff is needed.
Diabetes is associated with cognitive impairment in older people.
Diabetes is associated with increased aortic stiffness , but the importance of nondiabetic glucometabolic status for accelerated aortic stiffening is unclear.
Diabetes is associated with more severe signs in @percent@ of patients.
Diabetes is strongly associated with hypertension prevalence , awareness and lack of control of hypertension.
Diabetes mellitus and cancer are two growing health problems.
Diabetes mellitus and depression accounted for the higher odds of frailty in the barrio.
Diabetes mellitus and prostate cancer are @number@ of the most important public health concerns , especially in the elderly population.
Diabetes mellitus ( DM ) is an increasingly recognized comorbidity that can both accelerate TB disease and complicate its treatment.
Diabetes mellitus ( DM ) is one of the major non-genetic risk factors for Alzheimer disease ( AD ) .
Diabetes mellitus ( DM ) was the predictor of increased VA in both sexes , while metabolic syndrome ( MS ) only in women.
Diabetes mellitus increasingly afflicts our aging and dysmetabolic population.
Diabetes mellitus is an established risk factor for stroke.
Diabetes mellitus is an important risk factor for arteriosclerosis development in the elderly.
Diabetes mellitus is a risk for brain injury.
Diabetes mellitus is associated with extensive morbidity and mortality in any human community.
Diabetes mellitus is known to co-occur with geriatric conditions in older adults and has been implicated in the pathogenesis of some conditions.
Diabetes mellitus , obesity , and osteoporosis are very frequent pathological situations in older age.
Diabetes mellitus was self-reported diagnosis or a casual glycemia ≥ 200mg / dL.
Diabetes now affects both high- and low-income countries , with low-income countries bearing the majority of the burden.
Diabetes onset was identified by fasting and random plasma glucose level , HbA1c or the medical treatment for diabetes by questionnaire.
Diabetes predisposed to glucose elevation.
Diabetes-related complications accounted for one-third of these costs ( US $ 4 ) and , of these , @percent@ resulted from functional impairment.
Diabetes significantly lowers the chances of successful aging , and notably increases functional limitations and impairs quality of life.
Diabetes , smoking , and plasma triglycerides were associated with lower levels of many sphingomyelins and dihydrosphingomyelins.
Diabetes status was based on self-reports and haemoglobin A1c levels.
Diabetes , stroke , and suspected clinical depression had independent but weaker effects on cognition.
Diabetes treatment goals were achieved less often than BP and lipid goals , and concurrent diabetes was a significant predictor for BP and lipid control.
Diabetes was ascertained by standard American Diabetes Association criteria.
Diabetes was assessed per self-report , medication use , fasting glucose and / or glucose tolerance tests.
Diabetes was associated with CKD prevalence , whereas hypertension and hyperuricemia correlated more strongly with fast eGFR decline.
Diabetes was associated with lower CFR across quartile categories ( p < @number@ ) .
Diabetes was associated with the two-year cumulative incidence of acquiring new geriatric conditions ( odds ratio , @percent@ confidence interval : @number@ @number@.6-2.0 ) .
Diabetes was defined by either elevated fasting glucose ( ≥7.0 mmol / L ) or initiation of hypoglycemic medication during follow-up.
Diabetes was defined by self report , use of anti-diabetic medications and insulin.
Diabetes was diagnosed by clinical guidelines.
Diabetes was diagnosed by oral glucose tolerance tests.
Diabetes was found only in @number@ ( @percent@ ) patients.
Diabetes was not associated with drug treatment.
Diabetes was significantly associated with all markers of brain pathology.
Diabetes was significantly associated with lower scores on processing speed and executive function , but not with memory function.
Diabetic care-home residents with physical disabilities , cognitive impairment , tube feeding , and the inability to communicate pose particular challenges.
Diabetic complications were recorded , and HbA1c , FPG , TC , TG , and LDL were measured in the patients of the DM group.
Diabetic nephropathy ( DN ) is one of the major diabetic complications and the leading cause of end-stage renal disease.
Diabetic neuropathy is the third most common complication of diabetes mellitus.
Diabetic older adults are at a higher risk of muscle strength ( MS ) decline than their non-diabetic counterparts.
Diabetic patients have a higher risk of prostate cancer mortality , which is more remarkable with decreasing age.
Diabetic patients , including those with microalbuminuria , have a decreased ability to metabolize and excrete oxidants prior to observable changes in serum creatinine.
Diabetic patients may benefit from increased surveillance for these cancers.
Diabetic retinopathy ( DR ) is a complication of diabetes.
Diabetic retinopathy is related to excessive secretion of vascular growth factor ( vascular endothelial growth factor [ VEGF ] ) .
Diabetics started at higher weights.
Diabetic status was based on self-reported physician's diagnosis or treatment with anti-diabetic medication.
Diabetic vasculopathy is characterized as a compromised vascular dilatation , implicated in many diabetic complications.
Diagnosed diseases were assessed by a questionnaire comprising @number@ disease categories.
Diagnosed gout cases have been estimated at @percent@ of the @number@ US population.
DIAGNOSES : HNPP was diagnosed on the basis of clinical features , positive sural nerve biopsy findings , and genetic testing results.
Diagnoses of any vocal fold pathology were made via strobovideolaryngoscopy and laryngeal electromyography ( LEMG ) at the time of presentation.
Diagnoses of dementia and MCI were made using standard criteria via consensus diagnosis.
Diagnoses of morbidity were reviewed in patients ' case reports , and the local health-care register provided information on the use of health services.
Diagnoses of rheumatoid factor-positive polyarthritis and persistent oligoarthritis made respondents less likely and more likely , respectively , to withdraw JIA medications.
Diagnoses reported by clinicians were reclassified into International Statistical Classification of Diseases , 10th Revision categories.
Diagnoses were classified as infections or NCDs and analysed according to age and gender.
Diagnoses were derived from a multidisciplinary review.
Diagnoses were evenly distributed between clusters.
Diagnoses were made by considering clinical , neuropsychological , and MRI assessments collected by a multidisciplinary team of neurologists , neuropsychologists , and speech-language therapists.
Diagnoses were mapped and in cancer cases , Gleason grade , extent of disease , and perineural invasion were recorded.
Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging.
Diagnosis aggressively pursued by echocardiography and multiple blood cultures or surgical specimens has the potential to improve outcome.
Diagnosis and management barriers are presented with regard to GP , patient , and carer factors.
Diagnosis and severity assessment were defined according to current guidelines.
Diagnosis and treatment of depressive syndromes should be considered as a part of secondary prevention in patients with ischaemic stroke.
Diagnosis and treatment regimens of CKD are discussed.
Diagnosis codes further informed the nature of the injuries.
Diagnosis has to be pursued by means of MRI imaging techniques and tissue specimens.
Diagnosis is often clinical with subsequent histological confirmation.
Diagnosis is today based only on clinical assessments yet is often marred by concomitant precipitating factors.
Diagnosis may be difficult in older individuals , as multiple other common diseases can mimic IBD in this population.
Diagnosis of both irritant and allergic contact dermatitis is based on a thorough history , complete skin examination , and comprehensive patch testing.
Diagnosis of current major depressive symptoms followed Diagnostic and Statistical Manual of Mental Disorders , 4th Edition , Text Revision guidelines.
Diagnosis of FFP is very important : these fractures are highly disabling in elderly and can lead to displacement and instability.
Diagnosis of incident dementia was made by consensus diagnostic conference.
Diagnosis of PAD is obtained by ankle brachial index.
Diagnosis of pre-diabetes and diabetes was set according to the World Health Organization ( WHO ) criteria for fasting plasma glucose ( FPG ) level.
Diagnosis of prion disease typically relies upon immunodetection of PK-digested PrP ( Sc ) by Western blot , ELISA or immunohistochemical detection.
Diagnosis of RLS was based on a clinician interview.
Diagnosis of sarcopenia required the documentation of low muscle mass with low muscle strength according to the current international consensus definition of sarcopenia.
Diagnosis of sIBM is usually made @number@ years after onset.
Diagnosis of somatotroph adenomas is often long delayed and they are characterized by atypical clinical picture.
Diagnosis of vitamin B12 deficiency , however , is not straightforward as laboratory tests have certain limitations.
Diagnosis-oriented monitoring of cross-species proteostasis will constitute a solid basis for next-generation preventive medicine.
Diagnosis-stratified analyses revealed that this interaction was driven by the aMCI group ( p values = @number@ ) .
Diagnosis such as skin adverse event or infection should be quickly eliminated and the autoimmunity confirmed with skin and blood immunology and pathology analysis.
Diagnosis was made by psychiatrists using the Mini International Neuropsychiatric Interview plus ( MINIplus ) .
Diagnostic accuracy of posterior NbM volume was superior to hippocampus volume in both groups , despite higher multicenter variability of the BFCS measurements.
Diagnostic accuracy of the PHQ-9 and GDS-15 compared to the SCID was evaluated.
Diagnostic accuracy was improved compared to a previous study using data from only one administration of the exercise.
Diagnostic and management strategies applicable to younger patients cannot be empirically used to manage older breast cancer patients.
Diagnostic and prognostic tools are considered and therapeutic options discussed.
Diagnostic biomarkers are required to differentiate the different types of anemia and to treat them appropriately.
Diagnostic criteria have relied on a constellation of symptoms , but the definite diagnosis remains a pathologic one.
Diagnostic distribution of the breast lesions was as follows : @number@ positive , @number@ indeterminate / suspicious , @number@ negative and @number@ inadequate.
Diagnostic evaluation varies between facilities and depends on severity of illness and access to laboratory facilities.
Diagnosticians were blinded to performance on the predictive tests.
Diagnostic imaging techniques guided the decision to use the posterior episcleral buckling procedure.
Diagnostic labels ( Alzheimer's disease ( AD ) , cognitive impairment / dementia , brain injury / insult ) were listed for @number@ cases.
Diagnostic performance was also compared calculating the areas under the receiver operating characteristic curve.
Diagnostic performance was similarly poor among women and men and across age groups.
Diagnostic problems and improved management of changes in conditions were the most common avoidable readmission factors by hospitals and SNFs , respectively.
Diagnostics based on clinical examination and radiography have provided little information about metabolic changes in joint tissues , disease onset and progression.
Diagnostic tools , blood assessments and brain imaging were used in nearly all the facilities.
Diagnostic workup revealed hyperthyroidism and gonadotrophic deficiency attributed to significant supplement medicine usage.
Diag-NoSympt group displayed the lowest \ "not using preventive care. \ "
Dialysis dependency was more frequent among survivors @number@ years old or older ( @percent@ vs @percent@ ; p = @number@ ) .
Dialysis is also an arduous therapy known to shorten life.
Diameter and circumferential opening angle did not change with age in subjects with DM.
DIAPH2 has been associated with premature ovarian insufficiency , an aging phenotype in humans.
Diary data on menstrual cycle day and patterns of intercourse were used to calculate day-specific fecundability ratios.
Diastolic and mean BP decreased and pulse pressure increased , but systolic BP did not change between @number@ and @number@ years.
Diastolic BP and QOL remained unchanged ( P > @number@ ) .
Diastolic BP ( DBP ) decreased significantly in both groups ( 2TG : P < 0.001 ; 3TG : P < 0.001 ) .
Diastolic contributions to these biomarker associations were limited to young old participants whereas systolic contributions were found only in very old participants.
Diastolic function deteriorated more significantly among elderly women compared with elderly men.
Diastolic function get worse with increasing age.
Diastolic heart failure ( DHF ) is an important entity , the significance of which is increasingly recognized.
Diastolic heart failure is increasing in prevalence.
Diastolic indices were highly correlated with age.
Diastolic pressure was reduced in young old participants with isolated phosphorylated tau elevation ( P = @number@ ) .
Diazoxide hyperpolarized neurons , reduced the frequency of action potentials , attenuated Ca2 + influx through NMDA receptor channels , and reduced oxidative stress.
Dicarbonyl stress is produced by increased formation and / or decreased metabolism of dicarbonyl metabolites , and by exposure to exogenous dicarbonyls.
Dichotomising these biomarkers as normal or abnormal results in eight possible profiles.
Dichotomous ratings for memory and word-finding / language problems were given by patients and neurologists.
Diclofenac / misoprostol , nimesulide , naproxen , rofecoxib , ibuprofen , indomethacin , tarenflurbil , and celecoxib were the NSAIDs used in these reports.
Dieldrin and DDX were respectively @percent@ and @percent@ less bioavailable in contaminated soil relative to spiked soil despite > 40yr of aging.
Diet-alone interventions can detrimentally affect muscle and bone physiology and , without interventions to affect these elements , can lead to adverse outcomes.
Diet and BMI were important components to achieve ideal CVH metrics in children.
Diet and lifestyle were assessed in questionnaire-based interviews.
Diet and nutrients have gained significant interest as potentially modifiable protective factors.
Dietary AGEs are an important contributor to the AGE pool in the body.
Dietary and other lifestyle factors were studied using validated self-administered questionnaires.
Dietary assessment in older adults can be challenging.
Dietary assessment was done before and at the end of a 10-day intervention.
Dietary assessment was made by food-frequency questionnaire.
Dietary caloric restriction , inhibition of insulin-like growth factor-I signaling , and inhibition of the nutrient-sensing mechanistic target of rapamycin are robust longevity-promoting interventions.
Dietary characteristics of The Mediterranean Islands Study ( MEDIS ) sample display a favourable adherence to dietary recommendations ( Mediterranean diet ) .
Dietary consumption of food supplements has been found to modulate skin functions and can therefore be useful in the treatment of skin aging.
Dietary consumption of fruit , vegetables , fish , and olive oil has been demonstrated to exert beneficial effects on human health.
Dietary data were assessed through repeated 24-h dietary records.
Dietary data were collected at follow-up using a 195-item FFQ.
Dietary data were collected from a semi-quantitative food frequency questionnaire at baseline ( @date@ to @date@ ) .
Dietary data were collected from four , random , 24-hour dietary recalls over a 10-month period.
Dietary data were collected in 1991-1995 using a FFQ along with lifestyle and medical information.
Dietary data were collected using a 142-item food frequency questionnaire.
Dietary data were collected using a food-frequency questionnaire and physical activity was assessed by International Physical Activity Questionnaire ( IPAQ ) .
Dietary data were collected using a semi-quantitative FFQ , and servings of dairy product consumption calculated.
Dietary data were collected using a semi-quantitative FFQ beginning in @number@ ( exam @number@ ) .
Dietary data were collected using a validated food frequency questionnaire.
Dietary data were collected using repeated @number@ hr dietary recalls over a 1-year period , which were averaged to estimate habitual intake.
Dietary ( energy ) restriction increases lifespan in several model organisms , but it is uncertain whether it is effective in primates , including humans.
Dietary essential amino acids ( EAAs ) are the main driver of postprandial net protein anabolism.
Dietary factors may be important for prevention cognitive decline.
Dietary fat composition is an important factor in blood-brain barrier function and the blood cholesterol profile.
Dietary fiber has multiple health benefits.
Dietary guidelines and recommendations are outlined , current controversies regarding the evidence are discussed , and recommendations are made on the basis of the evidence.
Dietary habits were assessed retrospectively using a validated FFQ.
Dietary induced changes in microbiota and the host inflammatory response may underlie the subsequent development of acute / chronic diverticulitis and its sequela.
Dietary information was assessed with the use of a semiquantitative food-frequency questionnaire.
Dietary information was obtained from food frequency questionnaires.
Dietary intake , appetite , and mood questionnaires also were assessed.
Dietary intake is not one of the principal causes of anemia in the study population , except for folate intake.
Dietary intakes of DHA and fish were obtained from an earlier ( 1988-91 ) visit.
Dietary intakes of @number@ flavonoid classes and total flavonoids were assessed using a validated , semiquantitative food frequency questionnaire.
Dietary intakes were assessed at baseline through in-person interviews by using validated food-frequency questionnaires.
Dietary intakes were assessed using a food frequency questionnaire at baseline.
Dietary intakes were recorded before and at the end of the treatment and ingested sulfur amino acids were evaluated.
Dietary intake was adequate , confirming that HGPS does not represent a model of malnutrition-induced bone loss.
Dietary intake was assessed at baseline by a 3-day weighed food record and analysed for energy , calcium and other nutrients.
Dietary intake was assessed by either diet diaries or diet histories used in four FV randomised intervention studies.
Dietary intake was assessed by multiple unannounced 24-h telephone dietary recalls.
Dietary intake was assessed cross-sectionally using a food frequency questionnaire , and principal component analysis was used to identify dietary patterns from @number@ food groups.
Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire.
Dietary intake was controlled as a confounding factor.
Dietary intake was derived using a semiquantitative food-frequency questionnaire.
Dietary intake was established from three @number@ hour multiple pass recalls ( MPR ) .
Dietary intake was evaluated using a 24-hour dietary recall.
Dietary intervention of this kind , could also form the cornerstone of primary prevention of Type @number@ Diabetes Mellitus ( T2DM ) and cardiovascular disease.
Dietary interventions , especially calorie restriction , have been shown to improve the course of these diseases and to extend the lifespan.
Dietary interventions such as micro and macronutrients , as well as changes to the microbiota have been suggested.
Dietary knowledge was collected using twenty true / false items.
Dietary macronutrients are major determinants of life span.
Dietary pattern analysis represents a useful improvement in the investigation of diet and health relationships.
Dietary pattern analysis which considers dietary complexity has recently used to examine the linkage between nutrition and cognitive function.
Dietary patterns and some dietary components have been linked with dementia.
Dietary patterns based on food groups were evaluated by principal component analysis.
Dietary patterns may partly explain such a relationship , arguing for the importance of controlling for lifestyle confounders in future studies.
Dietary patterns that include saturated fats and meat products are potential risk factors for the progression of peripheral arterial disease ( PAD ) .
Dietary patterns were assessed by factor analysis.
Dietary potassium intake may serve as an important countervailing influence on the effects of salt in the vasculature.
Dietary protein had no significant effect on any of the cognitive domain scores.
Dietary protein intake was @percent@ higher at the end than before paracetamol treatment.
Dietary protein might improve cognitive performance ; however , this has hardly been studied.
Dietary protein's relation with fracture risk requires further investigation.
Dietary restriction ( DR ) regimens have been shown to extend health span and lifespan in many animal models including primates.
Dietary restriction increases lifespan and delays ageing phenotypes as well and mTOR has been assigned a major role in this process.
Dietary resveratrol treatment did not decrease plaque burden in APP / PS1 mice.
Dietary sodium intake was assessed by seven independent 24-h dietary recalls.
Dietary spermidine elicits cardioprotective effects in aged mice through enhancing cardiac autophagy and mitophagy.
Dietary supplement and placebo were administered @number@ times a day for @number@ weeks.
Dietary supplementation of probiotics with prebiotics ( synbiotics ) or without prebiotics has improved gut commensal diversity and regulated the immune system.
Dietary supplements are often used by the elderly to improve their nutritional status.
Dietary supplements were used by @number@ ( @percent@ ) patients ; @number@ ( @percent@ ) used two or more.
Dietary supplement use and potential confounders were assessed using a questionnaire at baseline.
Dietary TFA was estimated among @number@ adults free of prevalent DM when dietary questionnaires were initially administered in @number@ or @number@
Dietary underreporting , assessed by ( EI-TEE ) / TEE × @percent@ , was @percent@ for FFQ and @percent@ for repeated 24HRs.
Dietary variety was not significantly associated with changes in lean body mass or appendicular lean mass.
Dietary vitamin D intake was another factor associated with vitamin D status ( p = @number@ ) .
Dietary vitamin D intake was not associated to any of these outcomes.
Diet control and smoking status did not significantly predict hospital use after controlling for other factors.
Dietetic intervention could be a useful tool to ameliorate the development of inflammation and insulin resistance associated with ageing.
Dietetic technicians , registered , assist registered dietitians in the assessment and implementation of individualized nutrition care.
Dietetic technicians , registered , provide support to RDs in the assessment and implementation of individualized nutrition care.
Diet has been proved to be a powerful tool to modulate aging and caloric restriction has emerged as a valuable intervention in this regard.
Diethoyxdimethylsilane was found in all eluates from bleached specimens , but not in the control groups.
Diet in particular has become the object of intense research in relation to cognitive aging and neurodegenerative disease.
Diet plays an important role in mammalian health and the prevention of chronic diseases such as cardiovascular disease ( CVD ) .
Diet quality was evaluated by the Healthy Eating Index-2010.
Diet quality was evaluated by the Healthy Eating Index-2010 and the Mean Adequacy Ratio for @number@ micronutrients.
Diet rich in resveratrol promotes longevity and attenuates neurodegenerative diseases.
Diet score at Y0 and increase in diet score over @number@ years were also positively associated with each cognitive test.
Diets were assessed with a standard FFQ.
Diet therapy , now referred to as medical nutrition therapy , has long been investigated in the treatment of kidney insufficiency and kidney failure.
Diet was assessed by a 253-item FFQ.
Diet was assessed by a semiquantitative food frequency questionnaire.
Diet was assessed by a semiquantitative food frequency questionnaire.
Diet was assessed through a food frequency questionnaire , quantifying habitual intake over the past @number@ months.
Diet was assessed using 24-hour dietary recalls.
Diet was measured by @number@ nonconsecutive 24-h recalls.
Difference and agreement were assessed using paired t-tests , correlation coefficients and Bland-Altman plots.
Difference between consumed and served dietary content was evaluated by the Chi² test.
Difference between groups was assessed with 1-way ANOVA and χ ( @number@ ) analysis.
Difference between groups was assessed with one-way ANOVA and chi square analysis.
Difference in ALE / LE was striking in people with virile senility.
Difference limens ( DLs ) for increments of the tonal IOIs were measured to assess listener sensitivity to changes of sequence rate.
Differences across occupational groups were also examined.
Differences also may be reflective of variations in treatment approaches between age groups.
Differences among body composition markers were compared according to gender.
Differences among individuals in cortical MD may also arise from breakdowns in myelinated fibers running through the cortical mantle.
Differences among medical devices were found.
Differences between adults with and without diabetes were most marked in middle-age.
Differences between age groups were statistically significant ( ANOVA , p = 0.03 ) .
Differences between ages at the 5 ( th ) percentile rank of normal subjects were ~39% greater than mean differences in the AD subjects.
Differences between all target variables from baseline to follow-up , and between participants with and without dementia , were evaluated by bivariate and multivariate testing.
Differences between arms were strongest for waking at night ( P = @number@ ) and taking sleep medications ( P = @number@ ) .
Differences between CA and BA are due to intra-population variability , which could be the consequence of individual differences in aging.
Differences between CN individuals and individuals with MCI raise questions about the relevance of head injury-PET abnormality findings in those with MCI.
Differences between elderly and nonelderly groups were determined using the χ RESULTS : Of the @number@ subjects enrolled , @number@ ( @percent@ ) were elderly.
Differences between genetic subtypes were also statistically significant ( ANOVA , p < 0.01 ) .
Differences between groups were assessed with Kruskal-Wallis and χ tests.
Differences between groups were established using chi-squared and t-tests.
Differences between human , swine , rabbit , rat and guinea pig AChE were determined for the inhibition and reactivation kinetics.
Differences between men and women emerged , but similarities dominated.
Differences between methods were not significant for the overall group or for stratified groups.
Differences between methods will likely be more pronounced in aging and clinical populations.
Differences between Polish and German populations were observed.
Differences between the depressed and nondepressed and men and women were examined.
Differences between the left and right sides of the body were noticeably revealed by posturographic assessments in right-handed and right-footed children.
Differences between the second and third levels of education and between men and women were not significant.
Differences between women and men in terms of gender gaps at late stages of their lives are the focus of this mini-review.
Differences by NH size were found between small and medium or large NHs.
Differences existed in terms of cost and practicality.
Differences exist in comorbidity-related treatment outcomes , especially for patients with concurrent diabetes.
Difference should be made between assessment of risk and actual nutritional status , which should be assessed with specific malnutrition indices.
Differences in AGEs and RAGE expression between both groups were evaluated by RT-PCR , Western blot and immunohistochemistry.
Differences in airway physiology , breathing resistance , and aerosol filtering efficiency among the four models were quantified and compared.
Differences in baseline titers in aged individuals treated in the morning or afternoon in turn affected responsiveness to the vaccine.
Differences in body composition are associated with increased disease risk in various stages of life.
Differences in body weight at the last visit and body weight trajectories across birth cohorts were examined with linear regression and linear mixed-effect regression models.
Differences in Bone Mineral Density ( BMD ) between participants with and without LDD features were analyzed using ANOVA.
Differences in brain volumes have commonly been reported in older adults with both subthreshold and major depression.
Differences in cardiac physiology are seen between men and women in terms of health and disease.
Differences in cognitive ability among the three cohorts were small and primarily reflected demographic differences.
Differences in cognitive performance among healthy older adults may be related to differences in brain structure.
Differences in cognitive reserve may contribute to individual differences in cognitive function in the presence of comparable neuropathology.
Differences in common factors known to influence gait did not explain a @number@.79-cm / s slower gait speed in African Americans than Caucasians.
Differences in cortical atrophy were assessed between groups , as well as the effect of age within groups.
Differences in decision-making in older adults need to be accounted for in the design and implementation of financial incentive programs.
Differences in dietary fat may induce metabolic compensation in young adults that persist over three generations.
Differences in diet composition and study design between the @number@ on-going trials may explain the discrepancies in survival and disease.
Differences in dual-task gait speed appears to be largely attributable to executive attention processes.
Differences in findings across strata of sex , age and cognitive status ( cognitively intact versus cognitively impaired ) were examined.
Differences in fractional anisotropy ( FA ) -a DTI measure describing white matter ( WM ) microstructure-were analyzed by using whole brain voxel-based analysis.
Differences in frailty between rural and urban older adults have been demonstrated in developed countries.
Differences in frequency of unawareness were explored with McNemar tests for each region and agreement between variables calculated with Cohen κ.
Differences in function were also observed , as older animals exhibited increased ankle joint passive stiffness and decreased propulsion force during locomotion.
Differences in funding levels were calculated using ACFI and RCS instruments against a standardised CAPE score.
Differences in glycated hemoglobin and dosing frequencies between types of basal insulin warrant further comparative effectiveness studies.
Differences in health and mental health were examined between participants with low , moderate , or high levels of family contact.
Differences in health care utilization and expenditures between chronic and acute patients with and without MIP insurance were evaluated , using coarsened exact matching techniques.
Differences in HEI-2010 by patient characteristics and treatment exposure were examined by using ANCOVA.
Differences in IL-6 levels were registered across the education variables.
Differences in infant EEG between the nonsocial and joint attention conditions could be due to any of these three types of input.
Differences in menopausal age were analysed using linear regression analyses , with adjustment for possible confounders.
Differences in muscle activation and kinematics between cable-based and selectorized weight training.
Differences in muscle strength between the groups as well as intrarater and interrater reliability of two assessors were determined.
Differences in participant characteristics and intervention material use were studied through analysis of variance ( ANOVAs ) , chi-square tests , and logistic regressions.
Differences in patterns by birthplace may be explained by the Australian assisted-migration programme of 1945-1981.
Differences in physical activity between days on which different life-space areas were reached were tested using Generalized Estimation Equation models ( within-group comparison ) .
Differences in polypharmacy and hyperpolypharmacy between @number@ and @number@ were examined.
Differences in prevalence of geriatric syndromes between those with and without cancer were estimated.
Differences in proliferation , apoptosis and telomere length were assessed in addition to angiogenic properties of ADSC.
Differences in protein concentrations by frailty status were determined using analysis of variance.
Differences in protein secretion may indicate that hES-RPE may not function identically to native RPE after seeding on aged or AMD BM.
Differences in relative abundance and diversity of the donor fecal microbiota were analyzed in donors above and below @number@ years of age.
Differences in reproductive aging between women with type @number@ and type @number@ diabetes raise questions about potential differences in the mechanisms contributing to ovarian aging.
Differences in residential and nonresidential poverty exposure vary across gender , race / ethnicity , education , car ownership , and residential areas.
Differences in sense making were based on the context of the caregiving stressor , which in turn influenced the variability in caregiver's coping techniques adopted.
Differences in static and dynamic FC between EH and YH were calculated and compared by region.
Differences in survival were quantified by a concordance statistic ( c ) .
Differences in susceptibility to immune-mediated diseases are determined by variability in immune responses.
Differences in T2 spatial variation were greatest at the osteochondral junction ( p < 0.05 ) .
Differences in TASM were tested by ANCOVA , with age , height , and body mass index ( BMI ) as covariates.
Differences in the aspect of the dorsum of the hands were quantified and visualized using two methods.
Differences in the demographic and laboratory data of these patients were assessed , along with Kaplan-Meier analysis of survival using the log-rank test.
Differences in the distribution of birth dates by quarter year were determined using the Chi-square.
Differences in the neural basis of relational memory between children and adults are not well characterized.
Differences in the prevalence of etiological diagnoses indicate differences in the application of the diagnostic criteria.
Differences in these elements between the anemic and normal groups were compared by ANOVA.
Differences in the topography of the retinal vascular network may be a marker for cerebrovascular disease.
Differences observed in chemical composition could be explained by the industrial processes.
Differences remained significant after controlling for comorbidities ( hypertension , diabetes , smoking , hypercholesterolemia ) .
Differences that previously tended to be related to disease mechanisms could also be partly explained by demographic and clinical factors independent from the disease.
Differences to the normal were assessed in a Parkinson's disease and a stroke brain model.
Differences were also seen in gland pattern and gland content.
Differences were analysed between the response group and the corresponding population in mortality , hospital admission , days spent in hospital and number of diagnoses.
Differences were apparent concerning the visualization of morphologic features , especially for large aneurysms ( > 13 mm ) .
Differences were found in lesion morphology.
Differences were greatest early after surgery with equivalence by @number@ week.
Differences were more significant at longer treatment duration.
Differences were noted between respondents , with trainees rating lifestyle-related factors more highly compared with attending physicians.
Differences were regarded as significant if probabilities were less than @number@
Different adiponectin complexes exert tissue-specific biological functions and activate distinct signaling pathways.
Different age groups exhibited a tendency to more strongly cluster those values that they rated as relatively important.
Different approaches to calculating dietary ED do not appear to alter the direction of reported relations between ED and body weight.
Different arrangement patterns of the fat compartments around the facial rhytides were found.
Different associations emerged for depressed / nondepressed and men and women.
Different barriers to discussion about falls were identified.
Different blood donor groups require specific approaches and , for example , inactive or deferred donors must be re-activated.
Different BMD changing patterns were observed and a greater bone resorption was noted in all the conditions associated with poor bone quality.
Different brain imaging techniques allow the examination of the structure , biochemistry , metabolic state , and functional capacity of the brain.
Different candidate VZV drugs have been described in recent years.
Different caregivers showed varying degrees of emotional involvement , empathy , and efforts to find the meaning of the delusion for the person experiencing it.
Different cellular signaling mechanisms are involved process of aging that induces age-related changes in chondrocytes.
Different charting approaches resulted in barriers to communication between specialties and reduced confidence that other practitioners had received one's notes.
Different classes of teeth were evaluated.
Different clinical variants have been delineated , the most common of which is the behavioral variant ( bvFTD ) .
Different combinations of cluster analysis methods and statistical parameters were used to identify plausible classifications.
Different combinations of intervention strategy might be needed for MetS risk groups.
Different components of muscle health relate to different relevant outcomes and therefore require investigation of specifically targeted interventions in the hospitalized older population.
Different concepts such the Work ability or the Age management have been developed to allow a better response the professionals ' needs.
Different core thicknesses affected strength of the all-ceramic materials tested ( p < 0.05 ) .
Different corneal components ( epithelium , nerves , immune cells and endothelium ) underpin specific systemic complications of diabetes.
Different cortical representations have been associated with social interaction vs. self-generated episodic memory.
Different cut-off points should be used to identify infection using tympanal ( @number@.3°C ) or rectal ( @number@.9°C ) thermometry.
Different cutpoints of low lean mass and slow gait speed have been proposed by different professional working groups.
Different-day reproducibility was better than interobserver reproducibility.
Different degrees of AD pathology have been described according to distribution of NFTs in different topographical regions of hippocampus and cerebral cortex.
Different drugs employed in the handled of these conditions have showed decreases platelet activation and related markers.
Different effects on manoeuvring were observed depending on driver characteristics such as age and the extent of the field of view ( FV ) .
Different emotion regulation strategies are distinctly represented in the brains of younger adults.
Different enzyme deficiencies comprise the MPS III subcategories ( A , B , C , D ) .
Different expert opinion-based radiological criteria exist , yet these have not been validated.
Different factors influenced the completion of CDSMP workshop for caregivers and non-caregivers.
Different factors may account for racial differences in support of grown children versus aging parents.
Different factors played roles in different stages of HFpEF.
Different forms of GBS have been described having diagnostic confirmation of a previous infection with the ZIKV virus.
Different from the albumin levels , albumin variability was not dependent on chronological age but was independently associated with an individual's aging and death process.
Different from the longitudinal and circumferential strain , E and Poisson's ratio ( υ ) are values that directly present the rigidity of myocardium.
Different FS are based on different concepts of frailty , and most pairs cannot be assumed to be interchangeable.
Different gender role measurement approaches classified participants differently into gender role groups.
Different GFAP isoforms have been identified that are differentially expressed by specific subpopulations of astrocytes and that impose different properties to the intermediate filament network.
Different HA fillers for nasolabial fold correction were associated with various efficacies.
Differential activation in left dorsolateral PFC in young subjects and bilateral PFC activity in older subjects was observed to be associated with interference control.
Differential baseline expression of MuRF- @date@ suggest a regulatory attempt by the aging transcriptome to accommodate changes necessary for homeostatic maintenance.
Differential base rates empirically describe the potential clinical implications of failing to create an appropriate normative group.
Differential cell counts were reported as percentages and amount of cells / mg.
Differential changes in proteins governing caveolar and mitochondrial function may contribute to signal dysfunction and stress-intolerance.
Differential effects of prompting associated with impaired cognitive status were also examined.
Differential expression was observed between sampling seasons and the data suggest a weak response of genes related to immune system functioning.
Differential gene expression was evaluated using Illumina microarrays and validated with qPCR.
Differential HIV effects for LPTA and HPTA and better / worse ear were also examined.
Differential longevity of conscripts at older ages was investigated through the comparison of age-specific mortality rates and life expectancy estimates.
Differentially expressed genes were defined by using Benjamini-Hochberg false discovery rate approach ( P < 0.05 , expression ratios @number@ log2 fold change ) .
Differentially expressed platelet proteins were identified using Two-dimensional Differential In-Gel Electrophoresis and mass spectrometry.
Differentially expressed proteins were validated by Western blotting.
Differentially methylated regions ( DMRs ) have important implications for development , aging and diseases.
Differential methylation has a fundamental role in the development and outcome of malignancies , chronic and degenerative diseases and aging.
Differential relationships are observed between aPWV and TL , with an inverse association in younger individuals and a positive association in older individuals.
Differential tissue uptake was seen based on ASC transporter distribution.
Differential treatment effects were found across baseline depression class , suggesting the benefit for tailored intervention programs to improve depression outcomes among older adults.
Differentiated GBM cells still induced CD57 on CAR T cells and other activated T cells.
Differentiated neuroblastoma cells have been extensively used to study and understand the physiology and cell biology of neuronal cells.
Differentiated osteoblasts showed proper production of bone mineral matrix until passage @number@ in culture , suggesting a good differentiation activity.
Differentiating between Parkinson's disease ( PD ) and atypical Parkinsonism ( AP ) is clinically relevant but challenging.
Differentiating eosinophilic and neutrophilic disease accounts for atopic illness and distinguishes long-standing from late-onset asthma.
Differentiating the various filler materials , these effects are assigned to histopathology findings and currently available treatment options.
Differentiation and function of each T cell subset are controlled by a specific master transcription factor.
Differentiation between sites progressed with age , whereas roughness increased significantly with age for the dorsal hand and nose but not for the other sites.
Different indices of vascular risk are associated with low performance and with rates of decline in different cognitive domains.
Different individuals use these two strategies differently.
Different initial craniopharyngioma treatment approaches resulted in similar long-term health effects.
Different in-situ gel formulations of Cur were prepared using @percent@ of pluronic F127 , and @percent@ of carbopol P934.
Different interpretations of how these values should be expressed in specific situations led to different conclusions about what should be done.
Different kinds of stem cells possess distinct miRNA expression profiles.
Different light-curing protocols were also evaluated.
Different lines of evidence indicate that patients with schizophrenia ( SZ ) exhibit accelerated aging.
Differently , urine cultures showed no differences in bacterial growth for the pre-treated strain showing that it retained its ability to cause infection.
Different measures collected on a group level differed with respect to their psychometric quality.
Different mechanisms for this fundamental DHA role have been put forward.
Different mechanisms underlying calcium apatite accumulation are explored with these age-related disorders.
Different members of the heterogeneous nuclear ribonucleoprotein family are among the ribonucleoprotein family that bind more abundantly to TERRA.
Different methods have been used to define recovery , and the order reported is not consistent across the literature.
Different moderators and mediators may affect the extent and nature of the relationship.
Different morphological parameters including shape , size , and symmetry were evaluated.
Different motion parameters were compared in order to define a specifically designed protocol for seniors.
Different NC combinations were used during the model specification.
Different optimal age cut-offs for mutation testing are indicated for patients with and without epinephrine-producing tumors ( 44-49 vs. 30-35 yr , respectively ) .
Different pathogens were prevalent in different ages ; with respective seasonal distribution and characteristics.
Different patterns of resistance are seen , with multi-azole and pan-azole resistance more common than resistance to a single triazole.
Different patterns of risk factors by age can provide insight into the progression of frailty.
Different patterns of sleep disturbance seem to indicate the considerable variability of the aging experience across Europe.
Different phenotypes of hypertension have been described in younger and adult subjects with hypertension.
Different physical interventions induce the reinforcement of at least one of these two layers , thus increasing the effective macroscopic stiffness of the total composite.
Different procedures we dispose of have been reviewed together with their assets and their limits.
Different questions might have different weights , but the scores will be bounded , and are often scaled to the range 0-100.
Different research hypotheses are investigated with meta-analyses.
Different results regarding the way in which signatures tend to change with time , and their most and least stable features , are also given.
Different SEM values were found for full sample and sub-groups.
Different sensitivity analyses were made where adherence was defined different.
Different sensors can be included to check for particular contamination.
Different signalling pathways converge on autophagy to regulate lifespan in diverse organisms.
Different SIRT1 targets have been identified , including PTP1B , AMPK , FOXO , PGC-1α and IRS2.
Different stages of maturation arresting were more frequent in older patients.
Different strategies are used in order to maintain , optimize or diminish these deficits in people with and without dementia.
Different strategies may be useful in reducing inappropriate prescribing in the elderly.
Different subgroups of children were tested for recall of the events at ages @number@ @number@ @number@ @number@ and @number@ years.
Different T cell subsets are affected by this process.
Different techniques and approaches have been used to measure health in populations.
Different techniques for percutaneous or less invasive fixation of the posterior pelvic ring have been developed.
Different technologies are employed in cross-linking , and the products have varying rheological properties.
Different than in males , the female pelvic floor undergoes a number of adaptive changes related to life and endocrine events.
Different theories have been proposed to understand the growing problem of antibiotic resistance of microbial populations.
Different tissues are affected in those disorders : striated muscle , adipose tissue , central or peripheral nervous system and aging process.
Different TMZ dose regimens were tested , ranging from @number@ to @number@ mg / kg.
Different treatment modalities are used for the treatment and esthetic improvement of aging hands.
Different treatment options have been suggested but many have proven to be ineffective or associated with adverse events.
Different types of lasers with different mechanisms of action are available today for the facial rejuvenation.
Differing distributions of enrollees among health plans accounted for @number@ to @percent@ of observed disparities in @number@
Differing recommendations have been made regarding its utility in providing a profile of performance across several cognitive domains.
Difficult airway management was a common finding.
Difficulties in face matching , in terms of both accuracy and RT , were observed for subjects with AMD.
Difficulties in managing this condition with NF extent to deep anterior mediastinum is related to clavicle osteotomy or thoracotomy need with high surgical risks.
Difficulties in the ability to interpret and predict others ' mental states are related to destination memory decline in older adults.
Difficulties in the execution of goal-directed behaviours , and particularly their prospective memory component , can arise in ageing and have important consequences for autonomy.
Difficulties in updating information in working memory ( but not inhibitory problems ) partially mediated the age differences in false belief reasoning.
Difficulties planning for hypothetical health events and socio-cultural attitudes thwarting death-related discussions were emphasised.
Difficult participant recruitment is a consistent barrier to successful medical research.
Difficulty falling asleep or maintaining sleep , sleep duration and daytime tiredness were enquired.
Difficulty in detecting the transition between normal aging and the onset of dementia and the lack of a definitive diagnostic tool often precludes early diagnosis.
Difficulty in determining the exact onset of depression in subjects older than @number@ at the time of death.
Difficulty in disregarding irrelevant stimuli and thereby resorting to inefficient search strategy is proposed as the reason for the differences.
Difficulty of swallowing , called dysphagia , leads to aspiration pneumonia which is particularly a big health concern in aging societies.
Difficulty performing activities of daily living and instrumental activities of daily living was assessed at baseline and annually for the next @number@ years.
Diffuse axonal injury ( DAI ) secondary to traumatic brain injury ( TBI ) contributes to long-term functional morbidity.
Diffuse , optical near infrared imaging is increasingly being used in various neurocognitive contexts where changes in optical signals are interpreted through activation maps.
Diffuse plaques with no astrogliosis in layer VI related to dementia status ( OR = @number@ p = @number@ ) .
Diffuse small vessel disease and ceiling effect may account for the low topographic concordance we found.
Diffuse WMI disrupts the normal progression of OL lineage maturation and myelination through aberrant mechanisms of regeneration and repair.
Diffusion MRI adds another dimension by showing graded damage to white matter , making it more sensitive to white matter injury than FLAIR.
Diffusion tensor images were used to calculate Fractional Anisotropy ( FA ) images.
Diffusion tensor imaging analysis revealed a significant increase in FA in bilateral uncinate fasciculus and right inferior longitudinal fasciculus.
Diffusion tensor imaging ( DTI ) data was acquired , and tract-based as well as voxel-wise analyses were conducted.
Diffusion tensor imaging ( DTI ) measures HIV-associated white matter changes , but can be confounded by inflammation.
Diffusion tensor imaging ( DTI ) provides alternative information on microstructural white matter integrity.
Diffusion tensor imaging has been widely used to study brain diseases , disorders , development , and aging.
Diffusion tensor imaging studies show age-related differences in cerebral white matter ( WM ) .
Diffusion tensor imaging studies yielded conflicting findings on the relationship between HIV and age in neuroasymptomatic individuals.
Diffusion tensor imaging suffers from an intrinsic low signal-to-noise ratio.
Diffusion-weighted images ( DWI ) on MRI revealed extensive cerebral cortical hyperintensity.
Diffusion-weighted imaging ( DWI ) and graph theory can be used to evaluate major brain networks and detect signs of a breakdown in network connectivity.
Diffusion-weighted magnetic resonance imaging ( DWMRI ) is used to study white matter ( WM ) in normal and clinical populations.
Diffusion-weighted magnetic resonance imaging is a non-invasive imaging method that has been increasingly used in neuroscience imaging over the last decade.
Diffusive imaging has great diagnostic significance in early-stage AD.
Diffusivity of Bruch's membrane with regards to VEGF is a simple concept that can explain the variable response to anti-VEGF treatment in wet AMD.
DIGE analysis revealed @number@ differentially oxidized and @number@ differentially expressed protein spots with significantly different levels ( P < @number@ ) .
Digestion recovery of peptides was assessed and quantitative accuracy improved using heavy-isotope-labeled versions of the proteins as internal standards.
Digital audio recordings , field notes , and memos of the discussions were used to create verbatim transcripts.
Digital gene expression analyses showed that cells expressing the SUMOylation-deficient KDM5B harbor repressed mRNA expression profiles of cell cycle and DNA repair genes.
Digital images of sciatic nerve perineurium were further processed and analyzed with ImageJ software.
Digital images of the stained slices were afterwards morphometrically analyzed by ImageJ.
Digital images were analysed with the image analysis software.Statistics were performed with SPSS software.
Digital images were taken using a stereo-microscope and the microleakage and unfilled area proportions were assessed by using a software system.
Digitalized images of all samples were obtained by use of a stereomicroscope.
Digital photography , clinical grading , ultrasound and self-assessment scores confirmed improvement to wrinkle areas.
Digital photography is probably the best method used for this , with validation by other technologies.
Digital photography , ultrasound , cutometry , and corneometry measurements were also performed at each time point.
Digital photography was used for global evaluation while the numbers of lentigines and wrinkles were analyzed by VISIA.
Digital reconstructions of neuronal morphologies allow for complex quantitative analyses that are unattainable from raw images or two-dimensional tracings.
Digital Retinal images of both eyes were analysed using the VAMPIRE software suite.
Digital Retinal images of sufficient quality for measuring CRAE and CRVE were available for 51 / 75 ( @percent@ ) of participants.
Digital technologies are becoming more pervasive in all areas of society.
Digital veneering techniques offer a promising , time- and cost-effective manufacturing process for all-ceramic restorations and may usefully complement the digital workflow.
Digitial photography documented the treatment area at each visit ( days @number@ @number@ @number@ and @number@ ) .
Dignity must be evinced through the healthcare professionals ' treatment of elderly people and a system that meets their needs.
Digoxin , an ABCB1 activator , increased calcein efflux ( p < 0.001 ) .
Dihydroavenanthramide D ( DHAvD ) is a synthetic analog to naturally occurring avenanthramide , which is the active component in oats.
Dihydronicotinamide riboside : quinone oxidoreductase ( NQO2 ) is an enzyme that performs reduction reactions involved in antioxidant defense.
Dilated cardiomyopathy ( DCM ) is a multifactorial disease characterized by left ventricular dilation that is associated with systolic dysfunction and increased action potential duration.
Dilated cardiomyopathy ( DCM ) is the most frequent cause of heart failure and the leading indication for heart transplantation.
Dilated pores can be an early sign of skin aging and are a significant cosmetic concern.
Dilations to ACh and the simultaneous eNOS-derived H₂O₂ production were recorded in isolated pressurized cerebral arteries.
Diluted CaHA resulted in an overall increase in dermal thickness of @percent@ ( P≤0.05 ) .
Dimensional analysis was used to analyse @number@ interviews.
Dimensionality was further scrutinized by principal component analysis of the residuals.
Dimensionless ratios were calculated by dividing the cube size by the maximal aperture between the index finger and thumb.
Dimensions of longus colli ( LC ) and sternoclidomastoid ( SCM ) muscles were measured using ultrasonography ( US ) .
Dimensions of the head and pinna increased by factors of @number@ and @number@ respectively , reaching adult values by ~6 weeks.
Diminished lipo- and increased myofibroblast-like differentiation are directly regulated by specific Wnt-s , which process also controls surfactant production and pulmonary repair mechanisms.
Diminished mitochondrial function is causally related to some heart diseases.
Diminished OI may be a practical and affordable biomarker of AD pathology.
Diminished physiological reserve and the existence of multiple medical comorbidities present additional challenges to management.
Diminished skeletal muscle performance with aging , disuse , and disease may be partially attributed to the loss of myofilament proteins.
( D ) In vivo cross-polarized image at @number@ nm.
Diphenhydramine was the most common anticholinergic medication reported at baseline and year @number@ and meclizine at year @number@ for both races.
DIRAS3 KD ASCs lose the potential to form colonies and are negative for Ki-67.
Direct age-sex standardized rates were calculated for both cohorts for comparison.
Direct and indirect effects mediated through trait Harm Avoidance were examined in a structural equation model.
Direct and indirect effects of ageing-related stereotypic beliefs on self-efficacy and health-promoting behaviours were examined using path analyses.
Direct and indirect relationships between sports club membership , levels of physical activity and frailty were examined using a cross-lagged panel model.
Direct binding of miR-141-3p to the @number@'UTR of ZMPSTE24 transcripts was confirmed using a @number@'UTR-luciferase reporter assay.
Direct binding of PrxII to tankyrase ARC4 / 5 domains seems to be crucial for protecting tankyrase from oxidative inactivation.
Direct calorimetry was used to measure total heat loss ( whole-body evaporative heat loss and dry heat exchange ) .
Direct comparison of purified 20S proteasome and immunoproteasome demonstrated that the immunoproteasome can selectively degrade oxidized proteins.
Direct costs accounted for ~60% ( $ 65 billion ) and indirect costs accounted for ~40% ( $ 43 billion ) of the overall spend.
Direct costs - drug acquisition , monitoring and administration , and hospitalization costs - were estimated from the National Health Service perspective.
Direct costs included frequencies of primary and secondary sector contacts and procedures , and medication.
Direct costs of genotyping , hospitalization , therapeutic drug monitoring and drugs were included.
Directed acyclic graph and linear regression models were used.
Direct glucose toxicity likely plays a crucial role in explaining the clinical benefits of intensive insulin therapy in such critical patients.
Directing attention away from postural control and onto a cognitive task affords the emergence of automatic control processes.
Direct inhibition of IKKβ kinase activity and suppression of nuclear translocation of the NF-κB p65 subunit were observed.
Direct inhibition of the oncogenic transcriptional activity of MYC has been challenging to achieve.
Direct interviews were performed to inquire about sociodemographic characteristics , reproductive history , use of personal care products , and diet.
Directions and the ways of cancer spread in the anterior commissure is similar in men and women.
Directions for future research and applied implications are further discussed.
Directions for future research are discussed.
Directions for the use of prediction tools in clinical practice are given.
Directions of the supporting platform rotation were randomized across trials.
Directly after the letter-writing , the list of @number@ questions presented in PQ1 was presented again in a repeated procedure that was designated PQ2.
Direct measurements were made for the SP length , width , height , slope , and caudal morphology.
Direct medical costs are assigned.
Direct observation can then be used to identify behaviors suggestive of pain , and the patient's response to an analgesic trial can be observed.
Direct path from mother's education to cognition was significant but modest , and partially mediated by later SEP measures , particularly education.
Direct quantification of regional Aβ in relation to in vivo imaging is necessary to further enhance our understanding of the imaging-pathologic assessment correlation.
Direct recording of menus , weighing of ingredients used , and the preparation of dishes and drinks were undertaken.
Direct scores , derived scores , and reaction time ( RT ) were used as IPS measures.
Direct sequencing of KRAS , BRAF , and PI3KCA was conducted on tumor DNA.
Direct sequencing techniques is an efficient , accurate , and rapid means of diagnosing adenoviral keratoconjunctivitis.
Direct surgical treatment of cricopharyngeus noncompliance with or without diverticuli continues to show benefit and long-term results support a sustained improvement in three-quarters of patients.
Direct UVA exposure of human keratinocytes also stimulates the secretion of IL-6 , IL-8 and GM-CSF but not of IL-1 and endothelin-1.
Direct vagus nerve stimulation ( dVNS ) is known to improve mood , epilepsy , and memory.
Disabilities in the Instrumental Activities of Daily Living ( IADL ) are frequently observed in older adults.
Disability affects quality of life and increases health and social care costs.
Disability and cognitive status were assessed annually.
Disability and mortality rates per @number@ person years were @number@ and @number@ in men and @number@ and @number@ in women.
Disability and QoL measures varied according to the survey.
Disability becomes common only after age @number@
Disability , defined as difficulty in any of six activities of daily living , was assessed every 6-12 months for @number@ years.
Disability , dementia and frailty are risk factors for adverse outcomes and delirium after surgery.
Disability-free and healthy aging is closely linked to childhood health and medical conditions in young adulthood.
Disability in any of these activities was defined as the inability to perform the activity without assistance.
Disability in basic activities of daily living , mobility disability , and instrumental activities of daily living was assessed annually.
Disability in @number@ basic , instrumental , and mobility activities was assessed during monthly telephone interviews through @date@ .
Disability is a higher risk factor for nosocomial infections than the usual and well-known other parameters.
Disability is defined according to repeated measures of work limitations in prime working years.
Disability is defined as difficulty with mobility , independent living , self-care , vision , hearing , or cognition.
Disability is experienced disproportionately by Black and lower socioeconomic status ( SES ) individuals.
Disability is increasing among middle-aged adults and , reversing earlier trends , increasing among older adults as well.
Disability ( @number@ consecutive reports of severe difficulty walking one-quarter mile or climbing @number@ steps ) and mortality were determined for @number@ subsequent years.
Disability pension due to spinal pain was reported exceedingly rare before the age of @number@
Disability risk is elevated for all conditions studied , except heart attack.
Disability risks were striking.
Disability status at baseline is associated with financial insecurity persisting to Wave @number@ among survivors.
Disability was defined as a need for assistance in one or more ADL activities.
Disability was defined as difficulty in one or more of personal activities of daily living.
Disability was measured using the 12-item World Health Organisation Disability Assessment Schedule ( WHODAS ) @number@
Disability was measured using the Lawton instrumental activities of daily living ( IADL ) scale.
Disability was observed in @percent@ and @percent@ of PLHIV living in rural and urban places , respectively.
Disabling headache disorders are ubiquitous in all age groups , including the elderly , yet they are under-recognized , underdiagnosed and undertreated worldwide.
Disabling mutations in genome maintenance and DNA repair pathways are frequently observed in cancer.
Disadvantageous decision-making profile on the IGT was associated with higher level of apathy on the action initiation dimension.
Disadvantage was associated with depressive symptoms in women only ( OR = @number@ @percent@ CI = @number@ @date@ ) .
Disappointing because these facts clearly point at an environmental change in the 20th century in developed countries as a major factor in causing the epidemic.
( Disaster Med Public Health Preparedness.
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( DISC1 ) is a susceptible gene for schizophrenia ( Hodgkinson et al.
Disc degeneration was not correlated with a change in extensor muscle volume.
Discerning between these groups is a challenge worthy of further inquiry.
Discharge to a nursing home is increasing.
DISCLOSURE STATEMENT Neither the planners nor the authors have any conflicts of interest to disclose.
Discogenic back pain models must consider both emergent behavioral changes following pain induction and changes in the nervous system that mediate such behavior.
Disconnects were identified between employers and academic institutions and state government and providers regarding gerontology / geriatric training and education.
Discontinuation rate and frequency of side effects were more frequent in the oxybutynin group.
Discontinuation rate was not associated with clinical importance.
Discordance between self-reports and medical records reflects patient and provider factors that have implications for management and research.
Discordant conditions increased in prevalence faster among the oldest than youngest beneficiaries ( e.g. , dementia @percent@ points versus @percent@ points ) .
Discordant PiB had a greater effect than discordant FDG , and influence on diagnosis was greater than on treatment.
Discounting paradigms quantify the ability to refrain from preference of immediate rewards , in favour of delayed , larger rewards.
Discovered in Caenorhabditis elegans in @number@ microRNAs ( miRNAs ) make up a novel class of tiny , ~21-24 nucleotide , non-coding RNA species.
Discovered in the brains of multiple animal species , piRNAs may contribute to the pathogenesis of neuropsychiatric illnesses.
Discovered over a century ago , histones constitute one of the oldest families of proteins and have been remarkably conserved throughout eukaryotic evolution.
Discoveries relating to ARHL have revealed a unique link between ARHL and the underlying pathologies.
Discovery of a circulating factor ( suPAR ) that can modulate outside-in beta3 integrin signaling in recurrent focal segmental glomerulosclerosis provides exciting therapeutic possibilities.
Discrepancies among studies may be partly attributed to methodological differences , but the existence of publication bias in previous studies cannot be discarded.
Discrepancies between N1 / N2 ERP and TF results were obtained.
Discrepancies in reports between parents and children were associated with child and parent characteristics.
Discrepancies in reports of support reflect both self-enhancement and family context and may be an important source of misunderstanding and conflict between generations.
Discrepancy measured by individual difference score was lower than that measured by the residuals.
Discrepancy scores were calculated to assess awareness of cognitive functioning.
Discrepant findings are reported by independent studies concluding that MM is causally related to employment-related chemical exposures and to investigators with industry affiliations.
Discrete event history models show that dropout was related positively to ethnicity ( whites were more likely to drop out ) and health-related barriers.
Discrete measures and principal component analyses extracted amplitude and temporal waveform features.
Discrete measures at foot strike ( maximum and minimum ) were determined and compared between groups.
Discrete quality markers have been linked to director of nursing ( DON ) leadership behaviors.
Discrete-time Cox proportional hazard models were estimated.
Discrete time Cox proportional hazard regression models were used to examine the hazard for developing dementia associated with anemia.
Discrete-time Cox proportional hazards models were used to determine the risk of developing frailty.
Discrete-time hazard regressions and generalized linear regressions were used for analyses.
Discrete-time hazards models were used to compare the risk of weight gain ( ≥10 % ) among high adherers of each diet pattern.
Discrete-time survival analyses were used to estimate the effect of prior nonadherent behavior on initiating APD modifications.
Discrete-time survival analysis ( DTSA ) was used to relate multiple characteristics to the hazard function of alcohol onset across a relevant age range.
Discrete-time survival models were applied.
Discrete variables characterizing sagittal-plane knee function were compared among the four groups using ANOVAs.
Discriminant analysis and power analysis showed that CA1-2 was superior to total hippocampal volume for distinction between controls and MCI.
Discriminant analysis based on ERP & MRI markers classified correctly @percent@ of patients in RR , PP and SP subgroups.
Discriminant analysis showed that none of the components could significantly discriminate the groups.
Discriminant validity was then initially assessed on separate impaired and unimpaired groups.
Discrimination and calibration were assessed for models with IFG and with both IFG and elevated HbA1c.
Discrimination and reclassification abilities of invasive physiological indices were comparable for CFR.
Discrimination , depressive symptoms , and psychological and social resources were assessed via interview using validated measures.
Discrimination in healthcare may contribute to substandard experiences with the healthcare system , increasing the burden of poor health in older adults.
Discrimination of temporal order or coincidence is a criterion used by the brain to determine whether cross-modal stimuli should be integrated or not.
Discrimination of the models was assessed using c-statistics.
Discrimination of visual and auditory stimuli were good.
Discrimination performance of the older listeners with and without hearing loss was equivalent and significantly poorer than that of the younger listeners.
Discrimination performance of the two older listener groups was equivalent and significantly poorer than that of the younger listeners in each discrimination condition.
Discrimination power based on individual and combined measures are compared , based on stepwise logistic regression and 10-fold cross-validation.
Discrimination was not associated with poorer verbal fluency ( B = @number@ @percent@ CI [ @number@ @number@ ] ) at follow-up.
Discriminative validity was analyzed by comparing the total ABC-H scale scores between the faller and non-faller groups.
Disc space height was measured using a validated computer-assisted distortion-compensated roentgen analysis technique and reported in standard deviations from normal values.
Discussed are implications for enhancing everyday functioning throughout adulthood.
Discussed in this review are the efficacy , safety and mechanisms of salsalate relevant to the treatment of type @number@ diabetes.
Discussion.
DISCUSSION : Activities are more dynamic than disability , and time use is associated with disability.
Discussion : A cumulative index allows for gradations in resources that can be compensated for by external factors such as person-environment congruence.
DISCUSSION : Additional work is needed to shed light on the role played by race- and class-based segregation on group differences in social network turnover.
DISCUSSION : ADNI-3 will aim to inform AD treatment trials and facilitate development of AD disease-modifying treatments.
Discussion advocates a balanced approach to intervention design , and identifies opportunities for the further study of normative message framing.
DISCUSSION : AFC initiatives in Australia have had promising and varied starts with some aims to benefit disadvantaged older people.
DISCUSSION : African Americans are less likely to experience initial or recurrent falls than non-Hispanic Whites.
DISCUSSION : After sex , age , and demographics have also been considered , different terminal pathologies are associated with markedly different rates of decline.
DISCUSSION : Age , education , and race are consistently associated with cognitive performance in this sample of older community-dwelling adults.
DISCUSSION : A larger study is needed to examine associations between NTD and race , maternal smoking history , and infection.
DISCUSSION : All cases of SSI with instrumentation involved were cured by ICT support without removal of instrumentation.
DISCUSSION : AL may be a potential biomarker for early aging in countries with a strong social welfare system.
DISCUSSION : Almost one fourth of older hip fracture patients in this unit died within a year.
DISCUSSION : Along with the epidemiologic transition , chronic conditions have become the predominant contributor to disability burden among elderly persons in China.
DISCUSSION : Although accommodations are commonly used by older adult stroke survivors , unmet need is also substantial.
DISCUSSION : Although idiosyncratic environmental influences account for a large part of increasing variance , correlated and shared rearing environmental effects were also evident.
DISCUSSION : Although intuitively DSI may be expected to have additional impacts over single sensory impairment , research findings are inconclusive.
DISCUSSION : Although rare , when older characters did appear , they were depicted as socially engaged.
DISCUSSION : Although veterans experience better health relative to nonveterans around retirement age , they have poorer health than nonveterans among the oldest old.
DISCUSSION : Among older adults , anger expression predicted higher prevalence of metabolic syndrome.
DISCUSSION : Among older Mexican Americans , acculturation at baseline was protective of transitioning from a nonfrail or prefrail to a frail state.
DISCUSSION : Among the older people with cardiac disease , a physically active lifestyle was associated with lower mortality.
DISCUSSION AND CONCLUSION : A large gap was found between reported crimes related to elder abuse and the estimated prevalence of elder abuse in Italy.
DISCUSSION AND CONCLUSION : Associations between sex hormones and cognitive function were mostly non-significant.
DISCUSSION AND CONCLUSION : CCI was easier to use but the CIRS-G was better at evaluating comorbidity.
DISCUSSION AND CONCLUSION : DTD has a function of \ "dissolving phlegm \ " , thus it is chosen for the treatment of atherosclerosis.
DISCUSSION AND CONCLUSION : it was found that considerable variability in physiology exists within the paediatric population.
DISCUSSION AND CONCLUSION : Motivating themes remained consistent across the time intervals but the number of responses regarding barriers to exercise increased over time.
DISCUSSION AND CONCLUSIONS : In normal conditions , motivation interacts with cognitive control to modulate decisional aspects of a response in a conflict task.
DISCUSSION AND CONCLUSIONS : Intense focused ultrasound can be used as a non-invasive skin tightening technique in Asian patients.
DISCUSSION AND CONCLUSIONS : Our results show that destination memory in older adults is sensitive to familiarity of both destination and output information.
DISCUSSION AND CONCLUSIONS : These data indicate a role of adiposity in the development of inflammation and insulin resistance during ageing.
DISCUSSION AND CONCLUSIONS : The training successfully improved gait performance and therefore might be a promising approach to prevent falls.
DISCUSSION AND CONCLUSION : The Italian situation seems to be not well fitted to face the expected growing cancer burden.
DISCUSSION AND CONCLUSION : The multifaceted intervention is the first to combine both active-assisted cycling and resistance training.
DISCUSSION AND CONCLUSION : The outcome of the present intervention demonstrated the antioxidation , anti-aging and hepatoprotective nature of GL by effectively curbing oxidative stress.
DISCUSSION AND CONCLUSION : The themes include frailty and threats to the dignity of older persons and also capacity to feel and develop.
DISCUSSION : Anemia prevention and control programs in Uganda should target older people and correct misconceptions about the causes and treatment of anemia.
DISCUSSION : An increase of the value of PI was attributable to a twisting mobilization within the sacroiliac joint.
Discussion : Anosmia is common in older adults , particularly among blacks.
DISCUSSION : A rather stable connection was found between grip strength and cognitive abilities starting around @number@ years of age.
DISCUSSION : A relatively simple dance-based exercise can support lower-body functioning in previously sedentary , frail older adults.
Discussion : As the first HRS sister study undertaken in Africa , HAALSI adds vital information on population aging and health in the region.
DISCUSSION : A substantial percentage of the sample reported alcohol and substance misuse.
DISCUSSION : A survey-based adaptation of the MoCA was successfully integrated into a nationally representative sample of older adults , NSHAP Wave @number@
DISCUSSION : Attention should be given to the elderly , with special care devoted to elderly women.
DISCUSSION : Being perceived as a supportive spouse , as well as perceiving one's partner as such , has significant health implications.
DISCUSSION : Bisphosphonate treatment lowered ALP levels , and this decrease was strongly correlated with a decrease in BAP.
DISCUSSION : Building a sustainable model of EOL care requires respectful collaboration among governing structures , healthcare institutions , and community members.
DISCUSSION : By using the resulting sample weights , all results of ACTIVE analyses can be said to be nationally representative based on HRS demographics.
Discussion centers on the utility of these concepts and the implications for continued research into the ongoing relationships between fathers and adult children.
DISCUSSION : Changes are needed in practice , research , and education.
DISCUSSION : Changes in health behaviors are related to mental health in late life , but their effect is mediated by physical and functional health.
DISCUSSION : Cognitive ability and ability to act capture an important part of the education gradient in prevention whereas knowledge about illness explains little.
DISCUSSION : Cognitive training slows degradation of balance and improves gait while distracted , rendering it a promising approach to falls prevention.
DISCUSSION : Cohabitation and marriage have distinct implications for older adults ' patterns of partner care receipt.
DISCUSSION : Community livability is a process that varies considerably from the current conceptualizations.
DISCUSSION : Competing risks and benefits complicate medication use in the elderly.
DISCUSSION & CONCLUSIONS : Social workers ' direct involvement with the self-neglecting elders poses a very significant ethical , personal , and professional challenge.
DISCUSSION : Contrary to much previous research , tiredness decreases with age.
DISCUSSION : Correlations among multiple aspects of personality may mask unique associations of specific personality aspects with successful aging.
DISCUSSION : CR is associated with higher QoL in older adults.
DISCUSSION : CT in patients with AD showed a rate of thinning greater than what could be expected during the natural course of aging.
DISCUSSION : Current guidelines do not specifically address the problem of elderly with multiple chronic conditions.
DISCUSSION : Data collection began in Ontario and Alberta Canada in @date@ and is expected to be completed in @date@ .
DISCUSSION : Dementia care quality improved regardless of how care management was delivered ; large differences in effectiveness or cost offsets were not detected.
DISCUSSION : Depressed mood in older adults may be associated with accelerated age-related changes in sleep architecture.
DISCUSSION : Diabetes prevention approaches need to be targeted towards non-obese Filipino Americans , due to their high risk of diabetes.
DISCUSSION : Disability is associated with increased risk of ER visits , but not of subsequent hospitalization in community-dwelling elderly , independent of clinical conditions.
DISCUSSION : Drinking behavior in our aging population appears to be on a relatively promising course , perhaps reflecting the effectiveness of public health efforts.
Discussion Driving cessation is not a dreaded possible self for all older adults.
DISCUSSION : Due to its wide spectrum of parameters , the SVC technology can promote different biological responses.
DISCUSSION : Early-life educational quality and literacy in late life explain a substantial portion of race-related disparities in late-life cognitive function.
DISCUSSION : Engaging in meaningful occupations to support culturally valued roles were key elements in strengthening identity and facilitating personal , family and community health.
DISCUSSION : Estimates of genetic associations may differ for studies limited to clinic-only designs.
DISCUSSION : Exercise has known effects on immune function.
DISCUSSION : Facial expression items on observational scales for assessing pain in the elderly benefit from adherence to empirically derived descriptions.
DISCUSSION : Factors predictive of driving cessation vary by gender.
DISCUSSION : Findings are consistent with solidarity theory , which suggests that high-quality relationships may explain support.
DISCUSSION : Findings from this trial will potentially provide valuable evidence to improve physical function and maintain independence among older people from low-resource settings.
DISCUSSION : Findings have potential implications for targeting older adults at risk for loneliness.
DISCUSSION : Findings highlight the potential importance of dynamic aspects of positive affect in prediction of physical health outcomes such as mortality.
DISCUSSION : Findings provide new information about the relative burden of common chronic diseases among all older Americans and major subgroups.
DISCUSSION : Findings suggest that fluctuations in pain and depressive symptoms are common for older adults.
DISCUSSION : Findings suggest that @number@ mg of GBE twice-daily for at least @number@ months may improve dual-task-related gait performance in patients with MCI.
DISCUSSION : Findings suggest that social isolation is associated with poorer overall cognitive functioning and this remains true across varied cognitive domains.
DISCUSSION : Findings suggest that whether the age-related positivity effect occurs depends on the matching between cognitive processes and dispositional emotion regulation strategies.
DISCUSSION : Findings support a paradigmatic shift in worldview in old age heavily influenced by personal experiences.
DISCUSSION : Findings support renewed efforts to reimburse physicians for discussing end of life with their Medicare patients.
Discussion focuses on age differences in short term forgetting , working memory capacity , and the relation between forgetting rates and spaced retrieval schedules.
DISCUSSION : For most mobility activities , there are no systematic differences in the perception of difficulty by individual characteristics.
DISCUSSION : Four in five low-vision clients experience hearing impairment , and many have unmet needs.
DISCUSSION : Frailty is a strong predictor of adverse outcomes in older people hospitalized with acute illness.
DISCUSSION : Frank's sign could predict ischemic cerebrovascular events.
DISCUSSION : Further research on this age pattern might consider housing , the construction of the self , and social networks as explanations for retention.
DISCUSSION : Future research focusing on older couples needs to consider the couple's health context next to health at the individual level.
DISCUSSION : Gender , not the diagnosis of schizophrenia , was the major factor involved with LTL shortening across the age range studied.
DISCUSSION : Getting older people online has been a high priority in many countries over the past decade.
DISCUSSION : Grouped type I myofibers retain type II characteristics suggesting that conversion during denervation-reinnervation events is either progressive or incomplete.
DISCUSSION : Health is multidimensional ; all dimensions of caregiver health do not change in a uniform manner.
DISCUSSION : Health literacy tests that utilize a range of fluid cognitive abilities and mirror everyday health tasks frequently observe skill limitations among older adults.
DISCUSSION : HF clients are a more complex group than home care clients in general.
DISCUSSION : High adherence to all three diets may reduce AD risk.
DISCUSSION : Higher early orthostatic HR may be an independent risk marker.
DISCUSSION : Hip fractures remain highly debilitating events and pose significant challenges for the financing of public health insurance programs.
DISCUSSION : Histology of the ITA showed features of the elastic artery.
DISCUSSION : HOME Study is the first large scale study to test the use of home tele-monitoring system in the management of AMD patients.
DISCUSSION : Hospices are using internal resources and accessing community resources to provide patients with basic social needs not routinely covered by insurance.
DISCUSSION : Identification of modifiable risk factors should be our priority in clinical practice.
DISCUSSION : Impairment in executive function is specifically and linearly associated with higher health care expenditures.
Discussion : Improved TIP over @number@ years is associated with less risk of experiencing depressive symptoms.
DISCUSSION : Improvements in physical functioning of TKA recipients persisted in this longer term analysis of outcome in a nationally representative population study.
DISCUSSION : Improving physical working conditions may be important for reducing the influence of socioeconomic position on health after retirement.
DISCUSSION : Increased LEP was associated with slower rates of decline in physical and mental HRQoL in older Mexican Americans.
DISCUSSION : Individuals with AD have greater regional volume of WMSA compared to OC regardless of age or total WMSA volume.
DISCUSSION : Inflammation may be an important biological mechanism through which chronic medical conditions are linked to disability in later life.
DISCUSSION : Inflammatory processes may play a significant role in the cycles of pain and sleep disturbance.
DISCUSSION : In general , these positive effects justify the further development and refinement of CMCAC programs.
DISCUSSION : Initial training gain was comparable with magnitude of age-related cognitive decline over @number@ years with no training.
DISCUSSION : In our research , we observed that alpha-tocopherol acetate has no contraindications and side effects.
DISCUSSION : Intact social cognitive abilities are associated with better functional outcomes in individuals with schizophrenia.
DISCUSSION : Interventions should be developed to address preventable risk factors.
DISCUSSION : Interviewer and physician assessments may be complementary to self-assessed health measures.
DISCUSSION : In these Eastern European populations , late life cognition reflected life course socioeconomic trajectories similarly to findings in Western countries.
DISCUSSION : In this medically complex and highly dependent population , further study of how families and other caregivers impact health care utilization is needed.
DISCUSSION : In this study , injectable PLLA was found to be safe and effective for mid-face and nasolabial fold volumetric correction.
DISCUSSION : In this study the hyperlipemic group consisted from subjects with a relatively young age and with not very high serum lipid levels.
DISCUSSION : Involving patients and their family members in advance care planning may be challenging and time consuming for GPs.
DISCUSSION : It is important GPs are aware of the importance of early detection of dementia.
DISCUSSION : It is important to identify risk factors that may lead to older adults ' unmet needs for HCBS.
DISCUSSION : it is possible to embed CGA within EDs , which is associated with improvements in operational outcomes.
DISCUSSION : It may be possible to improve immunization rates in LTC facilities , at least modestly , using a collaborative training process.
DISCUSSION : Job strain is associated with elevated depressive symptoms among older workers.
DISCUSSION : L and Z status has been linked to benefits in cognitive function in past research.
DISCUSSION : Late onset hypogonadism has clinical features that overlap with both normal aging and some pathological conditions.
DISCUSSION : LDP is safe and feasible as ODP in selected elderly patients.
DISCUSSION : LLR is safe and feasible as OLR for treatment of HCC in selected elderly patients.
DISCUSSION : Loneliness is part of a constellation of poor social , emotional , and health outcomes for Chinese older adults.
DISCUSSION : Lower perceived neighborhood crime is associated with reduced presence of elevated symptoms of depression in older Latinos.
DISCUSSION : Low-income elderly Chinese city-dwellers prefer to age in place , given appropriate neighborhood support.
DISCUSSION : Marriage ameliorates mortality risks for some low-income men.
DISCUSSION : Medications used for COPD exacerbation management were prescribed at higher rate than those used for maintenance treatment.
DISCUSSION : Meeting the needs of the growing elderly population while maintaining them in the community is a particular focus of long-term care policy.
DISCUSSION : Men seemed to link satisfaction with body appearance more closely to body functioning than did women.
DISCUSSION : Middle-aged offspring use both personal and family-based resources to buffer the psychological ramifications of their mother's problems.
DISCUSSION : Mitochondrial biology is one of the fastest growing areas in genetics and medicine.
DISCUSSION : Most respondents were in the limited provider use class suggesting that for many problems , minimal professional help is utilized.
DISCUSSION : Most studies on the effect of exercise or physical activity consist of standardized programs.
DISCUSSION : MRI analysis techniques can be applied when comparing MRI data to autopsy results.
DISCUSSION : Multiglandular disease is more common in older patients than younger individuals , and minimally invasive approaches are less used in this patient group.
DISCUSSION : Multiple factors have been shown to affect telomere length.
DISCUSSION : Multiple processes bear on perceived stigma among people with chronic health conditions.
DISCUSSION : Muscle loss in critically ill patients preferentially affects the lower limb , possibly due to the lower limb becoming prone to disuse atrophy.
DISCUSSION : Nationally , CDSMP not only improves health outcomes and lifestyle behaviors but also decreases costly ER visits and hospitalization.
DISCUSSION : Nearly two-thirds of patients on AS experienced a decrease in eGFR and nearly one-fourth had upstaging of CKD classification.
DISCUSSION : Neither treatment method was associated with decreased mortality or better function after intra-capsular PFFs in patients older than @number@ years.
DISCUSSION : Normal physiological changes with aging affect both genders in terms of sexual desire and performance.
DISCUSSION : Now at the end of the recruitment phase , the evaluable population has amounted to @number@ people.
DISCUSSION : Objective sleep resulted disrupted in community-dwelling SCD , without any subjective sleep or cortical change.
Discussion of the positive effect on the inhibition of enzymes metabolizing carbohydrates in both in vitro and in vivo experiments are included.
Discussion of these themes was presented , and practice and research implications were suggested.
DISCUSSION : Old age need not be burdensome to individuals or society.
DISCUSSION : Older adults cite personal and affiliative beliefs , not lack of autonomy , as reasons for their choice to decide independently or delegate.
DISCUSSION : Older adults may show lower numeracy performance due to lack of motivation.
DISCUSSION : Older adults respond to stereotype threat by becoming vigilant to avoid the losses that will make them their worst.
DISCUSSION : Older age , female gender , and minority race were risk factors for current and future cessation.
DISCUSSION : Older and lower functioning participants had greater convergence on the fast- and usual-paced 400-m walks.
DISCUSSION : On balance , results are not overly encouraging for reductions in population-level disability given population aging and increasing life expectancy in China.
DISCUSSION : Only severe fall-based injuries are associated with fear of falling and activity restriction , and this relationship is unique to females.
DISCUSSION : Orthostatic tolerance was not reduced among elderly endurance athletes.
DISCUSSION : Our findings have implications for interpreting results from BMI-mortality studies and suggest caution in translating the findings into public health messages.
DISCUSSION : Our findings reveal that stressful life events are associated with stress-related neuroendocrine reactions for longer durations than researchers have previously documented.
Discussion : Our findings suggest concerns about the student debt crisis should extend to aging parents.
DISCUSSION : Our findings suggest that , during RBC ageing , GPI-linked proteins and integral membrane proteins are differentially sorted.
DISCUSSION : Our findings suggest that restoration of the expression of nuclear-encoded OXPHOS genes in aging could be a viable strategy for blunting AD progression.
DISCUSSION : Our findings suggest that smoking is positively associated , while alcoholic beverage consumption is inversely related to tooth loss in middle-aged Danes.
DISCUSSION : Our results identify ecological relevance as the key factor in older adults ' multitasking.
DISCUSSION : Our results indicate that cycles of DNA methylation contribute to the regulation of BMAL1 rhythms in the brain.
Discussion : Our results indicate that there is a decline in dark-adapted retinal activity as measured with the mfERG.
DISCUSSION : Our results indicate the existence of domain-specific age stereotypes that become internalized into older persons ' self-views.
DISCUSSION : Our results reinforce the diagnostic importance of AD pathology in clinical AD.
DISCUSSION : Our results reveal a critical role of DNA hydroxymethylation in AD pathology and provide mechanistic insight into the molecular mechanisms underlying AD.
DISCUSSION : Our results showed that ST can cause older people to perform at pathological levels on executive tasks.
DISCUSSION : Our results show the need of screening for depression when evaluating andropause symptoms.
DISCUSSION : Our results suggest that genetic variations of MC1R are important determinants for severe photoaging.
DISCUSSION : Our study is a unique resource of neuroimaging and cognitive measures relevant to change across the adult lifespan.
DISCUSSION : Our study revealed a high level of awareness and experience of elder abuse among the participants in both communities.
DISCUSSION : Overall findings highlight the importance of assessing the long-term health impact of volunteering and doing so under diverse social structural contexts.
DISCUSSION : Overall , findings on the characteristics of low activation patients in the Medicare population resemble previous research.
DISCUSSION : Overall , increasing the frequency of conflicting response presentation was detrimental to older but not to younger adults ' prepotent response performance.
Discussion : Overall , the findings demonstrate how race interacts with age and education to influence the probability of belonging to particular network types.
DISCUSSION : Pain presence , location , and intensity measures were successfully integrated into NSHAP Wave @number@ and exhibit construct and external validity.
DISCUSSION : Pain variability is an important characteristic that is not given enough emphasis in current literature.
DISCUSSION : PCO is a common , age-dependent finding among ovulatory women.
DISCUSSION : People who have objective cognitive decline seem to have more alexithymia features than people with subjective cognitive decline.
DISCUSSION : PEPFAR support allowed NAMBTS to leverage domestic cost-recovery revenue to rapidly increase blood collections and the distribution of RCC.
DISCUSSION : Perceptions of one's environment may either constrain or extend older people's life-space.
DISCUSSION : Perhexiline has become a \ "last-line \ " agent for refractory angina as a result of complex pharmacokinetics and potential toxicity.
DISCUSSION : Personality is associated with cognitive decline in older adults , with effects comparable to established clinical and lifestyle risk factors.
DISCUSSION : Physician assessment showed equal or superior average improvement in all measured categories with no statistically significant difference between the two sides.
DISCUSSION : Plantar pressure values were influenced by gait velocity but less by age and gender.
DISCUSSION : Potential fall risk may be increased by nCMSP , even in older adults with NMF.
DISCUSSION : Practitioners can use this information to help married couples through retirement planning and transitions.
DISCUSSION : Proper diagnosis and treatment are unavailable to many dementia patients because of a lack of dementia doctors and memory clinics in China.
DISCUSSION : Protective and risk factors identified can be helpful in formulation of different policies for older Indians.
DISCUSSION : Psychosocial factors may influence cognition in at-risk individuals ; influence varies by cognitive domain and ε4 status.
DISCUSSION : Psychosocial interventions have a small but statistically significant effect in reducing depressive symptoms among older adults.
DISCUSSION : Pursuit rotor tracking during controlled sentence production reveals the effects of aging on sentence planning and production.
DISCUSSION : QOL is a critical outcome measure.
DISCUSSION : RBD and daytime fluctuations of attention may coexist in DLB and even reciprocally potentiate each other.
DISCUSSION : RCD is sufficiently common to interfere with randomized clinical trials.
DISCUSSION : Recently , Zn in combination with ONS containing additional kilocalories , protein , and other trace elements , has been investigated for PIs.
Discussion regarding ways to improve nutrition care in each specific site facilitated the thought process during FG and interviews.
DISCUSSION : Relationships with adolescent and adult grandchildren seem to generally boost positive aspects of SWB.
DISCUSSION : Relocation has negative implications for the number of social support resources perceived to be available by older adults in rural China.
Discussion : Researcher-defined successful aging and self-rated successful aging are different measures with distinct social correlates.
DISCUSSION : Residents ' insights emphasize how personal characteristics influence community culture and the experience of place.
DISCUSSION : Results document links between the social networks and health of older adults in Lebanon within the context of ongoing demographic transitions.
DISCUSSION : Results from this study provide a large scale data on prevalence rates of pain and pain interference in this population.
DISCUSSION : Results of the research further our understanding of invariance of the HRS / AHEAD cognitive ability measures.
DISCUSSION : Results suggest that higher alcohol consumption in midlife may impair some components of executive function in late life.
DISCUSSION : Results suggest that lung function is important to consider when examining cognitive function in African American men.
DISCUSSION : Results suggest that multifactorial memory training can improve verbatim recall for prose , but the effect does not last without continued intervention.
DISCUSSION : Robot-assisted surgery is a safe and effective technique in aging patient population too.
DISCUSSION : Robust sex , educational , and social class differences in personality may contribute to late midlife social gradients in health and early aging.
Discussions addressed sleep disturbances , coping strategies , and beliefs and attitudes surrounding sleep.
Discussions also focused on scenarios in which financial motivations drive enrollment and disenrollment practices.
DISCUSSIONS AND CONCLUSION : This project encouraging older adults to be informed about different kinds of ICTs was positively rated.
Discussions based on a semi-structured schedule were conducted at five diverse hospitals from four provinces in Canada as part of the More-2-Eat implementation project.
DISCUSSION : Sensory function declines across age groups , with notable gender differences for hearing and light touch.
Discussion sessions with hospital administrators and participants afforded an opportunity for sharing data and additional assessment.
DISCUSSION : Several studies have shown that age alone is not a significant prognostic factor in survival after colonic surgery.
DISCUSSION : siCADs represent a rare but important cause of vascular dissection in the young.
DISCUSSION : Significant ethnic differences exist in the evolvement of self-rated health in middle and late life.
DISCUSSION : slow gait speed , PRISMA @number@ and the timed get-up-and-go test have high sensitivity for identifying frailty.
DISCUSSION : Social capital and loneliness are context dependent ( i.e. , geographical or living environment ) .
DISCUSSION : Social capital may not contribute as much as other neighborhood characteristics to mobility.
DISCUSSION : Social contacts have age and gender differential effects on psychological distress of mid-older Australian adults.
DISCUSSION : Social network type is a useful way to assess social integration within this model of cascading effects.
DISCUSSION : Some pilots possessed the capacity to resolve 20 / 25 lettering under obfuscating conditions ; others were adversely influenced by those same conditions.
DISCUSSION : Spouses ' interpersonal suffering may negatively affect both men and women's cardiovascular health , and older husbands may be particularly affected.
DISCUSSION : Statins may benefit WM in older adults vulnerable to dementia.
DISCUSSION : Strategy self-reports in the NP task can be considered valid measures of strategy use.
DISCUSSION : Strengths of the protocol vis-à-vis similar studies include opportunities to link biological factors with diverse content from other MIDUS projects.
DISCUSSION : Substantial numbers of older adults , many with care needs , live in a continuum of settings other than traditional community housing.
DISCUSSION : Successful aging is a complex process best described using a multidimensional model.
DISCUSSION : Suicidal ideation was common among U.S. Chinese older adults in the Greater Chicago area.
DISCUSSION : Surgical morbidity rate was not affected by age.
DISCUSSION : Survival after dementia diagnosis differs by race / ethnicity , with shortest survival among whites and longest among Asian Americans.
Discussions were held in different groups divided by gender and age on raw-fish-eating behavior.
DISCUSSION : Taken together , the results indicate that chronic pain significantly affects memory performance.
DISCUSSION : Taking into account how emotion reports differ based on method provides a more realistic picture of emotional experience in adulthood.
DISCUSSION : The 3- and 6-m courses had excellent test-retest reliability and faster walking speed in later than earlier trials.
DISCUSSION : The absence of effects on most indicators is encouraging for the future development of HIT in nursing homes.
DISCUSSION : The aging voice process is analyzed in detail from mechanical factors like pulmonary bellows alteration , to hormonal factors and life style.
DISCUSSION : The aim of the intervention trial is to improve pain management strategies in older people with dementia in nursing homes.
DISCUSSION : The analysis enables identification of underlying health-behavior dimensions in an understudied population.
DISCUSSION : The authors studied new parameters for LPND for improvement of wrinkles and skin laxity with fewer treatment sessions without serious complications.
DISCUSSION : The BACS appears to be a feasible and informative cognitive assessment tool for elderly patients with bipolar disorder.
DISCUSSION : The benefits of single room versus multi-occupancy room hospital accommodation has been recently debated.
DISCUSSION : The best criteria combined amyloidosis and neurodegeneration biomarkers , whereas the individual biomarker with the best performance was FDG-PET.
DISCUSSION : The burden of falls is significant.
DISCUSSION : The Canadian HIV and Aging Cohort will provide insights on pathophysiological pathways leading to premature CVD for patients living with HIV.
DISCUSSION : The challenges of international consortia like COSMIC include efficient communication among members , extended use of resources , and data harmonisation.
DISCUSSION : The combination of a range of health beliefs to form a cognitive representation made sense of the behavior of not seeking medical care.
DISCUSSION : The compromised health status and the diminished bone-healing capacity , in elderly , decrease chances for a good clinical outcome.
DISCUSSION : The computerized CogState battery , especially the iPad , was feasible , acceptable , and valid in the population.
DISCUSSION : The current study provides evidence and support for normativedata stratified by quality of education as opposed to years of education.
DISCUSSION : The daily-diary design provides detailed information for delineating how elders include complementary and other therapies in their health self-management.
DISCUSSION : The differential diagnosis among those entities is based on the microscopic features such as atypia and the number of mitoses.
DISCUSSION : The discussion considers coresidence as an intergenerational transfer and its importance for the contemporary aging society.
DISCUSSION : The findings acknowledge relationships between health characteristics , disability , and BMI among a national sample of older adults.
DISCUSSION : The findings clarify the relationship between age and SWB by demonstrating that the paradox of well-being is conditional on the economic context.
DISCUSSION : The findings confirm that older adults are more susceptible to fear-relevant illusory correlations than younger adults.
DISCUSSION : The findings demonstrate the durability of inhibition training gains in older adults for up to a 3-year period.
DISCUSSION : The findings of declining predictive validity of SRH across age imply that individuals may evaluate their health differently as they age.
DISCUSSION : The findings suggest that a health promotion intervention may achieve better beneficiary outcomes without an increase in resource use in this Medicare population.
DISCUSSION : The findings suggest that HCBS clients ' isolation and loneliness are linked to the types of social networks in which they are embedded.
DISCUSSION : The findings underscore the usefulness of subjective memory assessment in combination with other factors in identifying individuals at risk for developing dementia.
DISCUSSION : The findings will make an important contribution to evaluating cost-effective and evidence-based rehabilitation approaches for community-dwelling adults.
DISCUSSION : The intervention , if effective , has the potential to reduce disability and improve quality of life in older adults.
DISCUSSION : The KTA cycle provided a structure for the development of this evidence-based rehabilitation intervention , which was feasible to implement in the home.
DISCUSSION : The LSA may be a useful tool to identify older adults at risk of NH admission.
DISCUSSION : The MNA-SF is an efficient nutrition screening tool and it can be successfully used for the elderly veterans.
DISCUSSION : The model reveals a complex pattern of age- and time-dependent heterogeneity in late-life disablement.
DISCUSSION : The NSHAP provides a comprehensive assessment of geriatric health.
DISCUSSION : The overall results provided support for the expansion of morbidity hypothesis , and we discussed some possible reasons.
DISCUSSION : The phenotypic observations might in part explain unanticipated ( side- ) effects of tramadol.
DISCUSSION : The positive association between erythrocyte stability and RDW may reflect one possible mechanism involved in the clinical meaning of this hematological index.
DISCUSSION : The present findings suggest that age differences in emotion recognition are context and emotion specific.
DISCUSSION : The present study provides support for the use of video training.
DISCUSSION : The present study verifies the progressive decline of the skin mechanical properties with aging.
DISCUSSION : The proportion of foreign-born employees in nursing facilities may be associated with improved performance.
DISCUSSION : There are a number of unanswered research questions in relation to QOL in people with dementia living in long term care.
DISCUSSION : The reduction in serum concentrations of FT3 is a clear manifestation of stress associated with fractures.
DISCUSSION : The Registry has many features of an ' ideal ' incidence study.
DISCUSSION : There is a great diversity in the applications used obtaining different results on lifestyle improvement and weight loss.
DISCUSSION : There is robust evidence showing that an increased number of older adults will need substance abuse care in the coming decades.
DISCUSSION : The relationship between SMAs ( i.e. , self-efficacy ) and loneliness is promising , as SMAs can be learned through training.
DISCUSSION : The results of this study indicate that research is needed to determine what mediates the relationship between volunteering and hypertension.
DISCUSSION : The results show that there is a pattern on longevity in African American families that intersects with their stress experiences.
DISCUSSION : The results suggest that binge drinking frequently may be related to increased experiences of psychological distress among older drinkers.
DISCUSSION : The results suggest that the circumaural earmuffs currently incorporated into the flying helmet mitigate the risk of noise-induced hearing loss in these pilots.
DISCUSSION : The results suggest that the positive relationship between volunteering and health may decline when older adults discontinue or withdraw from volunteering.
DISCUSSION : The results suggest ways to protect marital quality among older adults who are struggling with physical illness in themselves or their partners.
DISCUSSION : The risk of catheter misplacement , PNX , and arterial / nerve puncture remains present with this technique.
DISCUSSION : The robustness of negative age stereotypes was expressed in their capacity to resist change as well as generate it.
DISCUSSION : These data demonstrate the safety and efficacy of the ThermiTIght procedure for the treatment of skin laxity.
DISCUSSION : These data suggest that longitudinal performance on an important real-world activity can be predicted by initial assessment of relevant cognitive abilities.
DISCUSSION : These findings demonstrate that early life experiences influence the trajectory of cognitive aging.
DISCUSSION : These findings highlight the importance of routine depression screening in older adults as a component of abuse prevention and intervention.
DISCUSSION : These findings illustrate that the family context of spouses is important to consider when examining health.
DISCUSSION : These findings imply that mindfulness skills may be an important link between age and negative affect.
DISCUSSION : These findings suggest that the receipt of care may make frail older adults more vulnerable to negative self-perceptions of aging.
DISCUSSION : These novel protocols yielded interpretable urinary OT and AVP values , with sufficient variation for analyzing their social and physiological associations.
DISCUSSION : These results and prior research indicate that cognitive SPT transfers to prolonged driving mobility among older adults.
DISCUSSION : These results suggest that Korean Red Ginseng is efficacious as an adjuvant treatment for patients experiencing residual symptoms of major depression.
DISCUSSION : These results suggest that spatial working memory decline across aging could contribute to age-dependent deterioration in both visuomotor learning processes.
DISCUSSION : These results suggest the importance of considering multiple perspectives and the direction of exchanges between generations.
DISCUSSION : These results support the use of the TA method by researchers of varying experience levels.
DISCUSSION : The slippery slopes is even more upsetting when dealing with elderly affected by chronic disability.
DISCUSSION : The study findings may have important implications for health policy and program development.
DISCUSSION : The study indicated a serious shortage of board-certified geriatricians and geriatric psychiatrists in Texas.
DISCUSSION : The study indicates the need for support services to family caregivers of older adults with ADL limitations.
DISCUSSION : The survey and actigraphy data provide different information about sleep characteristics.
DISCUSSION : The survival rate in clinical trials of CML treatment is higher than the survival rate of all patients with CML.
DISCUSSION : The tentacle strap system allowed for reduced skin incision thus minimizing surgical trauma and ensuring easier and faster implant placement.
DISCUSSION : The treatment of breast cancer is not standardized in the elderly.
DISCUSSION : The use of real stories contributed to the success of this intervention.
DISCUSSION : This clinical trial will assess the efficacy of repetitive DL-PDT in preventing AK and investigate possible rejuvenating effects of this treatment.
DISCUSSION : This feasibility study will be used to gather data to inform the design of a future definitive randomised controlled trial.
DISCUSSION : This intervention targets an underserved , difficult to reach population of older adults.
DISCUSSION : This paper offers an approach to Knowledge Translation within the field of ageing and health.
DISCUSSION : This population has a complex profile of health consequences linked to a heroin-using lifestyle.
DISCUSSION : This research suggests that neighborhood environment may have an influence on BMI above and beyond walking activity.
DISCUSSION : This review gives a complete overview on the management of ESBL-E in the high-risk setting.
DISCUSSION : This study addresses a significant shortcoming in aged care research , and has potential to impact upon a substantial health care problem.
DISCUSSION : This study aims at collecting precise clinical data , comprehensive geriatric assessment , risk factors , and biological data from acute care patients.
DISCUSSION : This study confirmed that endorsement of age stereotypes of PA predicted subjective vitality among active older adults.
DISCUSSION : This study demonstrates for the first time that there is no shortening of telomeres in the cortex of patients with depressive disorder.
DISCUSSION : This study documents variation in initiation ages , particularly for later-initiating tooth types.
DISCUSSION : This study examined respondents who were in the labor force at baseline and transitioned into retirement.
DISCUSSION : This study extends the negative effects of prior cognitive exertion to prospective memory in older adults.
DISCUSSION : This study has important practical implications for health care professionals , social service agencies , and concerned family members.
DISCUSSION : This study indicates that for day-to-day pain , catastrophizing significantly depends on pain type.
DISCUSSION : This study is the first randomized controlled trial specifically focusing on this neglected area.
DISCUSSION : This study provides the framework for an accessible and low cost online support group for a dementia caregiver.
DISCUSSION : This study suggests that filial piety receipt is an important risk factor for suicidal ideation among U.S. Chinese older adults.
DISCUSSION : This study suggests the potential benefit of daily UVA protection during nondeliberate exposure indoors as well as outside.
Discussion : This study supports the expansion of the successful aging model by incorporating ICT access and use.
DISCUSSION : This study tested the effects of a prescriptive exercise intervention alone , versus one supported by mobile health technology on cardiometabolic risk factors.
DISCUSSION : This study will be the first to prospectively elucidate the size of the effect of delirium upon cognitive decline and incident dementia.
DISCUSSION : This study will provide evidence of the effectiveness of a community-based self-management program for a complex target population.
DISCUSSION : To obtain better grounds to justify clinical decisions , specific reference intervals for laboratory parameters of the elderly are needed.
DISCUSSION : Ultrasonographic and roentgenographic gradings were consistent and patients with OP had lower scores for both gradings.
DISCUSSION : Under-recognition of delirium is a frequent issue.
DISCUSSION : Various types of lesions accumulated at different chemical and cellular levels during storage , which could impact their in vivo recovery after transfusion.
DISCUSSION : Vigorous physical activity appears to protect those experiencing high stress by buffering its relationship with TL.
DISCUSSION : Volunteer work but not participation in voluntary organizations yielded compensatory effects on mental health among older adults.
DISCUSSION : Wave @number@ of NSHAP included a variety of measures assessing the chronic conditions that are the most prevalent in older adults.
DISCUSSION : We characterize participants ' responses to symptoms as bricolages to highlight their construction from available materials.
DISCUSSION : We describe the challenges in the implementation and delivery into real-world settings.
DISCUSSION : We discuss possible underlying causes of the domain-specific nature of risk taking and age.
DISCUSSION : We examined the role of aging on racial disparity in disability and found support for the racial crossover effect.
DISCUSSION : We found a high prevalence of hypertension in our cohort and found that comorbidities and poor self-rated health increase the odds of hypertension.
DISCUSSION : We have demonstrated an association between increasing ECG-derived QRS duration > 140ms and the UCP2 DD polymorphism.
DISCUSSION : Younger elderly were more exposed to alcohol than previous cohorts.
Discussion : Young , middle-aged , and older adults have role models for successful aging.
Disease activity was evaluated using DAS28-ESR and DAS28-CRP at baseline , Week @number@ Week @number@ or at withdrawal.
Disease and biological function analyses and the KEGG pathway analysis revealed that these targets were statistically enriched in functionality for muscle growth and disease.
Disease-centric approaches to manage population ageing risk are adding years to life without adding health to these years.
Disease count was related to increased depressive symptoms , anxiety symptoms and negative affect and less positive affect.
Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old.
Disease-free , disease-specific , and overall survivals were similar between groups.
Disease-free survival times between the cohort of prostate cancers predicted to recur and predicted not to recur differed significantly ( p = @number@.38x10-6 ) .
Disease-modifying treatment ( if possible , methotrexate ) should be started as soon as the diagnosis of RA is made.
Disease onset was at the age of @number@ and presented as a behaviour disorder , particularly involving wasteful habits.
DISEASE OVERVIEW : Chronic lymphocytic leukemia ( CLL ) is the commonest leukemia in western countries.
Disease presentation and outcomes of these patients are unclear.
Disease progression ( n = 40 ; @percent@ ) was the main cause of death , and it was comparable in the two groups.
Disease-related treatments detrimental to bone should be considered when administering the BPAQ.
Disease-responsive transcriptionally active CpG were identified by means of differential methylation between preserved and lesional cartilage.
Diseases caused by pneumococci and influenza viruses can lead to severe complications in children , in older , chronically ill and immunosuppressed patients.
Diseases due to DNA damage repair machinery defects can resemble premature aging.
Disease severity was assessed by the International Cooperative Ataxia Rating Scale ( ICARS ) .
Disease severity was assessed using the unified Parkinson's disease rating scale including Hoehn and Yahr and Schwab and England ( S & E ) scales.
Disease severity was evaluated , together with data on the course of surgery , complications , and results.
Disease severity was similar throughout ICU stay.
Diseases of aging are often complex and multifactorial , involving many genetic and life course modifiers.
Diseases of digestive organs in men , and those of urino-genital system in women , cause main surgical interventions during this age period.
Diseases of the elderly , such as malnutrition , diabetes mellitus , treatment of malignancies , and vascular disease , all impair tissue repair.
Disease specific isoform compositions of tau are identified in these tauopathies.
Diseases that decrease mobility , such as arthritis , are likely to have a significant impact on quality of life.
Disempowering stereotypes plague public perceptions of older women's bodies , particularly within Western contemporary societies.
Disenfranchised grief can have negative emotional and physical consequences.
Disentangling the relationship between cognition and frailty may lead to new intervention strategies for the prevention and treatment of both conditions.
Disentangling the role of these overlapping processes is difficult since they require aged animal models and large samples of older human subjects.
Disfunction will occur in about @percent@ of diabetic patients.
Disk bulge prevalence increased from @percent@ of those @number@ years of age to @percent@ of those @number@ years of age.
Disk protrusion prevalence increased from @percent@ of those @number@ years of age to @percent@ of those @number@ years of age.
Disks were prepared with a surface conditioning as for copings provided for dental restorations.
Disorderly conditions , in particular , are believed to threaten health and to potentially accelerate functional decline.
Disorder of train of thought is one symptom of the formal thought disturbance.
Disorders in A-to-I RNA editing lead to serious abnormalities.
Disorders of the skeleton are one of the most common causes of chronic pain and long-term physical disability in the world.
Disparities between blacks and non-Hispanic whites and disparities across all racial and ethnic minorities in self-rated health still existed.
Disparities in public safety laws , health care infrastructure , and public funding may influence the risk of death and subsequent availability of deceased donors.
Disparities vary across states mainly because the prevalence of disability among low-educated adults varies across states.
Disparity-tuning functions for horizontal and vertical disparities were measured using the visual evoked potential.
Dispensings of antidiabetic and adjunctive cardiovascular medicines over the first six months of @number@ were examined.
Dispersion of high-molecular kininogen , inter-alpha-trypsin inhibitor , apolipoproteins AII and CIII peaks increased with age.
Displacement and neural activation ( EMG ) of the upper and lower lips were evaluated.
Displacement of MUFA and total PUFA was @number@ and @number@ % , respectively.
Displayed on a normogram , individually tailored trajectories can be used by counselors and participants to monitor weight loss and adherence to a CR regimen.
Displays of social emotion command excessive cortical processing in impulsive suicide attempters.
Dispositional hope , perceived health , and social support were the strongest predictors of satisfaction with life.
Dispositional optimism and other positive personality traits have been associated with longevity.
Dispositional optimism may be a psychosocial process linking socioeconomic status with health.
Dispositional optimism was associated with less health pessimism and life event stress was associated with greater pessimism among those in good OH.
Disputes were resolved by consensus.
Disregarding nurses ' preferences , however , bears the risk for further resource deterioration.
Disrupted CARs are associated with health declines and could affect cognitive aging.
Disrupted function of endothelial colony-forming cells ( ECFCs ) may contribute to this enhanced risk.
Disrupted oxygen metabolism may result from cellular aging processes and may putatively represent the underlying pathogenesis of oncocytoma.
Disrupted PM processing was found to correlate with stereotypical behaviors in FTD syndromes , a finding that we suggest is worthy of further investigation.
Disrupted sleep patterns are a significant problem in the elderly , leading to increased cognitive dysfunction and risk of nursing home placement.
Disrupted sleep was associated with altered pain processing by sex and ethnicity / race.
Disruption correction adjusted this estimate to account for co-worker disruption , while friction correction accounted for labor substitution.
Disruption in resting state functional connectivity MRI ( rs-fcMRI ) has been reported in AD and in healthy controls at risk for AD.
Disruption of CatS therefore induces hyperlocomotor activity due to failure to downscale the synaptic strength.
Disruption of DAF-25 , which localizes to sensory cilia , produces no apparent cilia structure anomalies , as determined by light and electron microscopy.
Disruption of Il11 in the NRF2 addiction cancer model remarkably inhibited the tumorigenesis , suggesting an essential role of IL-11 in NRF2-driven tumorigenesis.
Disruption of mitotic microtubules induced dissociation of NS from the chromosome arms and scattered it into the cytoplasm.
Disruption of normal fetal development can influence functioning of organs and cells in adulthood.
Disruption of synaptic plasticity processes that underlie learning and memory contribute partly to this pathophysiology.
Disruption of telomere maintenance pathways leads to accelerated entry into cellular senescence , a stable proliferative arrest that promotes aging-associated disorders in some mammals.
Disruption of TFAM results in heart failure and premature aging in mice.
Disruption of the balance of epigenetic networks could become the etiology of several ocular diseases.
Disruption of the functional network architecture possibly contributes to deficits in facial emotion recognition frequently reported in MTLE.
Disruption of the genes necessary for the circadian clock to function has diverse effects , including aging-related phenotypes.
Disruption of the GH receptor ( GHR ) gene eliminates GH-induced intracellular signaling and , thus , its biological actions.
Disruption of the Krebs cycle is a hallmark of cancer , and MDH2 has been recently identified as a novel pheochromocytoma and paraganglioma susceptibility gene.
Disruption of the niche after muscle damage results in their exit from quiescence and progression towards commitment.
Disruption of these mechanisms in AD results in a reduction of CREB activation with accompanying memory impairment.
Disruption of the short range order of proteins present in the ocular lens leads to cataract resulting in a loss of transparency.
Disruption of the tumor-suppressive p53 network is a key event in human malignancies , including primary liver cancer.
Disruption of this interaction in human aortic endothelial cells prevents Arg1 S-nitrosation and activation.
Disruption of this mechanism has been implicated in the development of cancers.
Disruption of this process contributes to neurodegenerative diseases including AD , and many of the molecular players in AD are also modulators of adult neurogenesis.
Disruptions in circadian regulation can lead to impairment in the formation of memories and manifestation of other cognitive deficits.
Disruptions in the physiologic maintenance of the redox potential in neurons interfere with several biological processes , ultimately leading to cell death.
Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and can profoundly affect health.
Disruptions to functional connectivity in subsystems of the default mode network are evident in Alzheimer's disease ( AD ) .
Disruptions to the immuno-skeletal interface drive skeletal deterioration contributing to a high rate of bone fracture in HIV infection.
Dissecting the molecular pathways controlling genomic stability at stalled forks is critical.
Disseminated fusariosis is a rare disease , and data are scant in pediatric patients.
Disseminated infection was present in @number@ %.
Dissemination of evidence-based advice and followed up with referral during consultations , particularly in general practitioners could advance falls prevention practice.
Dissemination of these programs to rural communities remains limited.
Dissimilar to young adults , VCoP-Post2 , Post3 ML were larger than Pre ( P = 0.01 ) in older adults.
Dissolution behavior of the four model GPC formulations was evaluated by measuring ion release profiles as a function of time.
Distally , the only difference found in either bone was a significantly greater fibular medullary cavity in the very old group.
Distal MCAO was induced by electrocoagulation , and hESC-derived NPCs were transplanted into the infarct cavity @number@ weeks later.
Distal outcome analysis compared confirmed 6-month abstinence rates among the latent classes.
Distal radius fractures are one of the most commonly treated fractures in the United States.
Distal radius fractures include a spectrum of injury patterns encountered by general practitioners and orthopedists alike.
Distance and near visual acuity , contrast sensitivity , peripheral vision , visual processing speed , and visuospatial skills were assessed at baseline.
Distance high-contrast visual acuity and Pelli-Robson letter contrast sensitivity were also assessed for all three visual conditions.
Distances from the temporal pole to the dentate gyrus showed the most significant differences when comparing control and AD groups.
Distances walked during @number@ s and numbers of category exemplars generated in the semantic fluency task showed an inverted U-shape function with age.
Distance to the practice and continuity of caregiver seemed to conflict for respondents.
Distance travelled from home was determined with geographic information system ( GIS ) software.
Distant metastasis is the main cause of breast cancer-related death ; however , effective therapeutic strategies targeting metastasis are still scarce.
Distant visceral metastases occurred significantly more often than bone metastases in both age groups ( p < 0.001 ) .
Distinct developmental trajectories in different functional circuits in ASD likely reflect differential age-related changes in the socio-cognitive processes they underlie.
Distinct disulfide-linked TDP-43 dimers and oligomers were detected.
Distinct features remarkably different between these two groups of disulfides were identified , and a SVM-based classifier for predicting reversible disulfides was developed accordingly.
Distinct from previous research , we examine the effects of maltreatment in the context of more general parental evaluations.
Distinct genetic variants were associated with CeAD.
Distinctive cortico-striatal circuits that serve motor and cognitive functions have been recently mapped based on resting state connectivity.
Distinct measures of primary and secondary prevention have been investigated to reduce the risk of morbidity and mortality caused by lung cancer.
Distinct molecular mechanisms allow lncRNAs either to activate or to repress gene expression , thereby participating in the regulation of cellular and tissue function.
Distinct molecular repertoires of SOM peptide and receptors were associated to sensory or cortical olfactory processing structures.
Distinct physical changes affect the feet in the elderly population.
Distinct stem cell Ang II receptor subtypes are critical for regulation of muscle regeneration.
Distinguishing between different types of ER visits makes no difference.
Distinguishing between those variants is only possible with pathological examination of brain.
Distinguishing the many indolent tumors from the minority of lethal ones remains a major clinical challenge.
Distractors presented through the auditory modality can be filtered at both central and peripheral neurocognitive levels.
Distributed activations to phonetic changes were identified in the temporal , frontal and parietal regions.
Distributed lag models were additionally used for estimating cumulative effects of air pollution on pterygium.
Distributional analyses showed that younger people have a higher propensity to commit impulsive errors during exercise , which was not evident in older adults.
Distribution by age and sex of the Temperament and Character Inventory ( TCI ) dimensions were assessed cross-culturally for samples in Spain and the USA.
Distribution of vitamins intake was estimated using traditional and national cancer institute ( NCI ) methods.
Distributions of allele and genotypes frequencies in different age groups including old men and long-livers have been characterized.
Distributions of improved ratings among investigators and subjects were similar for both sides of the treatment area.
Distributions showed a fattening of the right tail in each consecutive phase , meaning a stronger increase in higher percentiles.
Disturbance of the structural integrity of cerebral fibre tracts-the so-called cerebral network-by ARWMC might be one explanation for this development.
Disturbances at this critical time can affect the long-term health of the offspring.
Disturbances in both daily rhythms and sleep are associated with increased risk of heart disease , adverse cardiovascular events , and worsening outcomes.
Disturbances in glucose metabolism and adipocytokine release were detectable in old ( obese and normal-weight ) and young obese patients.
Disturbances of the fronto-striatal-thalamic pathways responsible for motor control and impulse inhibition have been previously described in other studies.
Disturbances of the prolactin / vasoinhibin axis are associated with the pathogenesis of retinal and cardiac diseases and with diseases occurring during pregnancy.
Disturbances of the swallowing process can occur at any age and might lead to choking.
Disturbances to astrocytic mitochondrial homeostasis and their ability to produce ATP can negatively impact neural function.
Disturbed flow in particular is thought to play a key role.
Disturbing is the fact that so few respondents admitted that in their companies , there were activities conducted concerning health promotion.
Dis was not obviously different among the three groups.
Diuretics and beta-blockers should be discontinued where feasible , whereas low-dose aspirin can be continued if otherwise indicated.
Diuretics are commonly used in elderly patients , but recent outcomes data have raised doubt about their long-term benefits.
Diuretics are relatively safe , and angiotensin-converting enzyme inhibitors are preferred to treat HF accompanied with COPD.
Diuretics should be used with caution in elderly.
Diurnal change of serum melatonin level in Alzheimer's disease showed decreased amplitude and shifted peak secretion.
Diurnal changes in HRV in young and middle-aged adults were compared using a two-way , repeated-measures analysis of variance ( ANOVA ) .
Diurnal rhythmicity in testosterone within and between Ache men in association with age ( n = @number@ age range , 18-64 ) was therefore examined.
Diurnal type ( chronotype ) differentiates individuals on an axis between the extremes of evening type to morning type.
Divergence in gene expression due to cis-regulatory variants in noncoding regions is central to disease susceptibility.
Divergence was assessed with adjustment for multiple testing.
Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages.
Divergent thinking abilities were measured using the Alternative Uses Task.
Divergent thinking is scored as the number of different actions performed.
Divergent thinking likely plays an important role in simulating autobiographical events.
Divergent thinking shows the ability to search for new ideas , which is an important factor contributing to innovation and problem solving.
Divergent thinking was significantly associated with the amount of episodic detail for imagined future events.
Divergent validity ( DV ) was measured by comparing BAM-COG scores to the National Adult Reading Test IQ ( NART-IQ ) estimate.
Diverse and specific epigenetic changes are suggested to correlate with neuronal development , learning and memory , aging and age-related neuronal diseases.
Diverse cell types have unique transcriptional signatures that are best interrogated at single-cell resolution.
Diverse cellular signaling systems are involved in pathogenesis of these diseases.
Diverse DUBs directly or indirectly affect the ubiquitination of p53 and , consequently , regulate various cellular processes associated with p53.
Diverse effects of memory training were observed in the literature.
Diverse environmental cues converge on and are integrated by the mTOR signaling network to control cellular growth and homeostasis.
Diverse factors , including adhesion molecules , growth factors , and cytokines are important for embryo implantation through improving endometrial receptivity.
Diverse pathological features have been identified , and their disease relevance remains much debated.
Diverse treatment strategies aim at maximum cytoreduction and ensuring good quality of life.
Diverse winners took unique paths to change their built environments and encourage physical activity.
Diversity of a sample is calculated based on three independent measurements of one Vβ-Jβ family of TCR rearrangements at a time.
Diverticular bleeding was found in @number@ ( @number@ % ; mean age , @number@ years ) and was predominantly bilateral ( @number@ % ) .
Diverticular disease comprises both diverticulitis and diverticular hemorrhage.
Diverticulosis coli , commonly seen in the elderly , like hernia , was once attributed to stress and strain from constipation.
Diverticulosis is the most common pathological finding in routine colonoscopy.
Diverticulosis , right and bilateral type , and diverticular bleeding were independently associated with the 9-year trend after adjustment by age and sex.
Divided by sex , in the research participated @number@ women and @number@ men.
Dividing attention during encoding disproportionately reduced memory for backgrounds ( versus items ) relative to a full attention condition.
Dividing the expressed PINs into modules , we examined the stability of the modules with AD progression and with normal aging.
Division of adenomyosis cells to the 26th passage is stopped and these cells entered into a phase of replicative aging.
DJ-1 prevented protein glycation in an Escherichia coli mutant deficient in the DJ-1 homolog YajL and restored cell viability in glucose-containing media.
DJ-1 was reported to be a multifunctional oxidative stress response protein with poorly defined function.
DJS reduced 6-OHDA-induced intracellular ROS production and GSH depletion and inhibited mitochondrial membrane instability , cytosolic cytochrome c release , and caspase-3 activation.
DKI measures and neurite density correlated well with myelin water fraction and intracellular and extracellular water fraction.
DLB and AD patients had elevated choline / creatine , and myo-Inositol / creatine in the posterior cingulate.
DLB is characterized by a loss of parietooccipital WM integrity , independent of concomitant AD-related β-amyloid load.
DLB pathologic diagnosis was made according to consensus criteria , using α-synuclein immunostaining for Lewy body identification. β-Amyloid immunostaining was used for quantifying β-amyloid deposits.
DLB patients were characterized by decreased N-acetylaspartate / creatine ( NAA / Cr ) in the occipital voxel.
DLB was diagnosed based on the McKeith diagnostic criteria.
DLK1 ( PREF1 ) is an established marker for mouse adipocyte progenitors which inhibits adipogenesis.
DLMO to sleep offset phase angle narrowed with age in the younger cohort and became broader in the older cohort.
DM2 versus non-DM showed a higher ( CONCLUSION : Progressive deterioration of renal function each year is frequent in hypertensive diabetic and non-diabetic patients.
DM2 was associated with increased CCR2 expression , which may restrain monocyte traffic to the lung.
DmHsp22 was found to be functionally active in human cells.
DMH-specific Prdm13-knockdown mice also exhibited progressive increases in body weight and adiposity.
DM is a serious disease ; the correct evaluation of any skin lesion suggesting an early diagnosis is of utmost importance.
DMN and WCP values were correlated to global cognition and episodic memory performance.
DMN individual values showed a sensitivity of @percent@ and specificity of @percent@.
DM patients also had higher incidence of urine retention after surgery.
DM patients had relatively poor treatment outcomes compared to DM-free patients.
DMSCs transplants is effective in treating light aging skin.
DMSCs were treated with UV lamp irradiation to establish light aging skin model.
DM seems to be an independent risk factor for MCI and Alzheimer's disease ( AD ) and is associated with more rapid cognitive decline.
DMSO and CA inhibited hyperosmolarity-induced VCAM-1 expressions , while increasing nitrite levels and Ser1146-eNOS expression.
DM was cross-sectionally associated with pain and disability and marginally with perceived health ; SS predicted current pain and perceived health.
DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process.
DNA and RNA were encapsulated by Imagene and shipped at room temperature to participating laboratories.
DNA aneuploidy and mean nuclear genomic aberrations were associated with patients ' age.
DNA available from one patient showed a homozygous frameshift mutation in tripeptidyl peptidase II ( TPP2 ) abolishing protein expression.
DNA breaks activate the DNA damage response and , if left unrepaired , trigger cellular senescence.
DNA damage accumulation has been widely associated with aging in differentiated cell types.
DNA damage also could induce tissue inflammation that disturbs the homeostasis of systemic metabolism.
DNA damage and mutations of different types clearly accumulate with age in mammalian tissues.
DNA damage causally contributes to aging and cancer.
DNA damage could impair metabolic organ functions by causing cell death or senescence.
DNA damage impinges on genetic information flow and has significant implications in human disease and aging.
DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age.
DNA damage is an important contributor to endothelial dysfunction and age-related vascular disease.
DNA damage is a recurring phenomenon in our bodies which could be induced by exogenous agents and endogenous metabolism.
DNA damage is composed by multiple stress factors including ionizing radiation , reactive oxygen species , UV exposure and drugs like doxorubicin and camptothecin.
DNA damage is linked to multiple human diseases , such as cancer , neurodegeneration , and aging.
DNA damage is tightly associated with various biological and pathological processes , such as aging and tumorigenesis.
DNA damage marker 8-OH-dG was determined using 8-hydroxy-2-deoxy Guanosine StressXpress ELA Kit by StressMarq Biosciences.
DNA damage , mostly oxidative , plays a key role in the development of most common NCDs.
DNA damage plays a major role in various pathophysiological conditions including carcinogenesis , aging , inflammation , diabetes and neurodegenerative diseases.
DNA damage plays an important role in mutagenesis , carcinogenesis , aging and several other pathophysiological conditions.
DNA-damage response and repair are crucial to maintain genetic stability , and are consequently considered central to aging and longevity.
DNA damage triggers complex cascade of signaling events leading to numerous posttranslational modification on multitude of proteins.
DNA damage was assessed in the HeLa and MS751 cells using alkaline comet assays and by detection of γH2AX focus formation.
DNA damage was detected by performing the single cell gel electrophoresis ( comet ) assay.
DNA-dependent protein kinase ( DNA-PK ) , a central player in DNA double-strand break ( DSB ) repair , shows emerging roles in metabolic regulation.
DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability , if not efficiently repaired.
DNA double-strand breaks are the most dangerous DNA lesions that may lead to massive loss of genetic information and cell death.
DNA double-strand breaks are toxic lesions and two main pathways exist for their repair : homologous recombination and non-homologous end-joining.
DNA double-strand breaks ( DSB ) are serious DNA lesions.
DNA double-strand breaks ( DSBs ) are deleterious lesions that lead to genetic mutations and cell death.
DNA double-strand breaks ( DSBs ) are highly toxic lesions , which , if not properly repaired , can give rise to genomic instability.
DNA fibers are often used to display the progress of replication forks by immunofluorescence of nucleoside analogues incorporated during short pulses.
DNA fragmentation as well as disomy of sex chromosomes and disomy @number@ did not show a statistically significant change with age.
DNA fragmentation was detected by TUNEL assay , while aneuploidy was assessed by FISH.
DNA from aged is hypomethylated and hypomethylation is associated with increased immunogenecity of self DNA.
DNA from peripheral blood leukocytes ( PBL ) and brain samples were analyzed for the presence of CMV , EBV , or HHV-6.
DNA hydroxymethylation in gene bodies was predominantly positively correlated with cis-acting gene expression.
DNA hypermethylation and impaired hematopoietic differentiation in AML after isocitrate dehydrogenase @date@ mutation and 2-hydroxyglutarate increases were outlined.
DNA lesions caused by UV damage are thought to be repaired solely by the nucleotide excision repair ( NER ) pathway in human cells.
DNA methylation ( 5-methylcytosine [ 5mC ] ) is one of several epigenetic markers altered in Alzheimer's disease ( AD ) brain.
DNA methylation affects expression of associated genes and may contribute to the missing genetic effects from genome-wide association studies of osteoporosis.
DNA methylation ages were calculated by two algorithms proposed by Horvath and Hannum et al.
DNA methylation age was compared to chronological tissue age.
DNA methylation as well as other epigenetic modifications such as chromatin remodelling and histone modifications are indispensable in mammalian development.
DNA methylation at the fifth position of cytosines ( 5mC ) represents a major epigenetic modification in mammals.
DNA methylation decreased with exercise ( @percent@ of loci ) .
DNA methylation ( DNAm ) is an attractive candidate mechanism.
DNA methylation ( DNAm ) is an important epigenetic process involved in the regulation of gene expression.
DNA methylation , genomic imprinting , and histone modifications are examples of epigenetic factors known to undergo change in the aging and cancerous prostate.
DNA methylation has been acknowledged as one of the key epigenetic mechanisms involved in the regulation of gene expression and genomic functions.
DNA methylation in body fluids is a stable , easily detectable and promising PC biomarker.
DNA methylation is an epigenetic mechanism that evidently plays a role in Alzheimer's disease ( AD ) .
DNA methylation is an epigenetic mechanism that modulates gene expression in mammalian cells including T cells.
DNA methylation is an epigenetic process involved in development , aging , and cancer.
DNA methylation is an important epigenetic modification and is frequently altered in cancer.
DNA methylation is currently one of the most promising age-predictive biomarkers.
DNA methylation is known to be an important regulatory mechanism of gene expression.
DNA methylation is not only an inherited but also modifiable epigenetic mark that has been related to cardiovascular risk factors.
DNA methylation is one of the most well-studied epigenetic alterations in mammals.
DNA methylation is regulated by DNA methyltransferase , of which DNA methyltransferase @number@ ( DNMT1 ) is the most abundantly known.
DNA methylation levels ( Illumina 450K platform ) were used to estimate the DNAm age.
DNA methylation may reflect biological impact of air pollution.
DNA methylation measured in specimen repeats collected at intervals of @number@ years decreased more markedly in exposed subjects than in controls.
DNA methylation , mitochondrial DNA copy number and telomeres shortening are cellular modifications associated with an increasing number of tumors , cardiovascular and aging diseases.
DNA methylation modification , one of the epigenetic mechanisms regulating gene expression , is considered a hallmark of cancer.
DNA methylation of cytosine residues is a stable epigenetic alteration , beginning as early as foetal development in the uterus and continuously evolving throughout life.
DNA methylation of genes with altered expression was determined by bisulfite-specific ( BSP ) PCR.
DNA methylation of MGMT may regulate the expression of the gene and be involved in the development of ARC.
DNA methylation , one of the best-characterized epigenetic modifications , plays essential roles in development , aging and diseases.
DNA methylation patterns can be inherited and influenced by the environment , diet and aging , and disrupted in diseases.
DNA methylation plays an important role in the self-renewal of hematopoietic stem cells and in the commitment to the lymphoid or myeloid lineages.
DNA methylation plays critical roles in transcriptional regulation and chromatin remodeling.
DNA methylation provides a mechanism for transmitting environmental effects on the genome , but its potential role in LRTIs is not well studied.
DNA methylation testing is better than HPV genotyping triage and is competitive with or complementary to other approaches such as cytology and p16 staining.
DNA methylation was explored with the Infinium 450K bead array.
DNA methylation was measured by bisulfite pyrosequencing.
DNA methylation was measured using bisulphite pyrosequencing method.
DNA methyltransferase 3a ( Dnmt3a ) , which catalyzes DNA methylation , is essential for memory formation and underlying changes in neuronal and synaptic plasticity.
DNA methyltransferase @number@ ( DNMT1 ) is a major epigenetic regulator associated with many biological processes.
DNA mutations are inevitable.
DNA-PK phosphorylates WRN in response to DNA double strand breaks ( DSBs ) .
DNA probes specific for chromosomes X ( DXZ1 ) and Y ( DYZ3 ) were used and > 100 cells were analyzed / patient.
DNA repair genes are involved in several diseases such as cancers and autoimmune diseases.
DNA repair in mitochondria is a regulated , stress-responsive process.
DNA repair is a crucial factor in maintaining a low steady-state level of oxidative DNA damage.
DNA repair is a prerequisite for life as we know it , and defects in DNA repair lead to accelerated aging.
DNA repair is essential for life , yet its efficiency declines with age for reasons that are unclear.
DNA repair not only plays a pivotal role in suppressing mutagenesis but also in the reversal of signals inducing the stress response.
DNA repair pathways are generally thought of as mutually exclusive mechanistic units handling different types of lesions in distinct cell cycle phases.
DNA repair was first documented for the nuclear compartment but evidence was subsequently extended to the organelles.
DNA replication fork progression can be disrupted at difficult to replicate loci in the human genome , which has the potential to challenge chromosome integrity.
DNA replication is a tightly regulated process that initiates from multiple replication origins and leads to the faithful transmission of the genetic material.
DNA samples were analyzed for germline mutations in BRCA1 , BRCA2 , and @number@ other cancer predisposition genes.
DNA samples were obtained from the lens capsules of patients following cataract surgery , and subjected to PCR amplification.
DNA SBs and DNA repair were positively correlated with age.
DNAse I sensitive studies indicated that both AGE-α-synuclein-scDNA and α-synuclein-scDNA are resistant to DNAse I digestion.
DNA sequencing of the entire Rhesus macaque genome , completed in @number@ has demonstrated that humans and macaques share about @percent@ of their nucleotide sequence.
DNA sequencing was required for the identification of @number@ ( @percent@ ) rare point mutations and determination of clinically significant chimera junction sites.
DNA storage typically requires the use of freezers.
DNA strand breaks triggers a set of highly orchestrated signaling events known as the DNA damage response ( DDR ) , which coordinates DNA repair.
DNA tandem repeats that cap chromosome ends , known as telomeres , are sensitive to oxidative damage and exposure to ionizing radiation.
DNA topoisomerases pass DNA strands through each other , a function essential for all DNA metabolic processes that create supercoils or entanglements of DNA.
DNA vaccination , interferes with tumour vessel formation and transplanted tumour growth in vivo.
DNA was bisulfite modified followed by PCR amplification and pyrosequencing to determine the level of DNA methylation at each CpG site.
DNA was collected from patients who attended an ALS specialty clinic that receives referrals from neurologists throughout Finland.
DNA was extracted , amplified by polymerase chain reaction , and screened for the C1367T polymorphism in WRN using restriction enzymes followed by sequencing.
DNA was extracted for Apolipoprotein ( APOE ) genotyping.
DNA was extracted from leukocytes , and DNA methylation was measured with the Infinium 450K BeadChip.
DNA was extracted from peripheral blood leukocytes ( collected 1996-1999 ) .
DNA was extracted from plasma using standard protocols and serostatus was determined by enzyme-linked immunosorbent assay.
DNA was extracted from whole blood to assess LTL via quantitative polymerase chain reaction.
DNA was isolated from blood samples and a region encompassing the insLQ polymorphism was sequenced.
DNA was isolated from cells separated before and after culture with ConA for telomeric measurement by real-time polymerase chain reaction.
DNMT1 expression decreased in passage-aged fibroblasts and DNMT1 silencing in young fibroblasts induced the senescence phenotype.
DNMT2-mediated RNA methylation could promote RNA stabilization upon curcumin treatment.
DNMT3A-R882 mutations were most common and , although their prevalence increased with age , were found in individuals as young as @number@ years.
DOAC was started early in @number@ patients ( @percent@ ) .
Docetaxel remains a cornerstone of therapy for the patient with metastatic castration-resistant prostate cancer ( CRPC ) .
Do children and adults use the same cues to judge whether someone is a reliable source of information ?
Docking studies were employed to substantiate the experimental results.
Docking was then further employed using AutoDock pyrx and validated through discovery studio for studying molecular interactions.
Doctors are neither more nor less susceptible than the general population to the effects of ageing.
Doctors , pharmacists and nurses need to reevaluate their practices.
Documentation of discussions about signs and symptoms of dementia , treatment options , care , support , financial , legal and advocacy advice were uncommon.
Documentation of wellness interventions and outcomes of these interventions presented ongoing challenges.
Documented AEs were infrequent , mostly mild in severity , and declined in frequency over time.
Documented reproductive aging patterns in female vertebrates , including humans , are consistent with canonical aging patterns determined developmentally and require no special adaptive explanation.
Doenjang pills significantly activated radical clearance capacity ( ORAC and DNA tail length ) in subjects with the C allele.
Doenjang-treated subjects tended to have low dietary carbohydrate and sodium intakes compared with those given placebo.
Does a speaker's face influence the way their voice is heard and later remembered ?
Does it matter that rodents used as preclinical models of human biology are routinely housed below their thermoneutral zone ?
Does our postreproductive survival contribute to our fitness , or is it just a chance event , a result of selection on other characteristics ?
Does prospective memory with focal vs. non-focal cues decline with aging ?
Does the capacity to modulate afferent input to spinal motor neurons during steady submaximal contractions change with advancing age ?
Does the relative role of socioeconomic and behavioral risk factors in explaining race differences vary when examining men and women separately ?
Does the size of age-related declines with focal vs. non-focal cues vary across ProM subdomains ?
Does this agent reflect the priorities of the patient ?
Does understanding depend on a logical approach ?
Does use of MT4C help carers of community-dwelling older adults with ADRD and MCC deal with significant changes they experience as carers ? and @number@
DOFA was highest within the peripapillary sclera ( ppsclera ) , with relatively low values in the lamina cribrosa ( LC ) .
Dogs were recorded in a testing room and the video recordings were subsequently analysed.
Doing housework as part of IADL is an important skill needed for older people to live independently and successfully.
Do leg movement adjustments also fall into these two categories ?
Domain experts were asked to identify research priorities and challenges and separate them into mechanistic , translational , and clinical categories.
Domain interaction is , therefore , a viable therapeutic / prophylactic target for cognitive impairment and AD in apoE4 subjects.
Domain of sexual symptoms of the AMS scale reduced more significantly in patients of groups @number@ and @number@ ( p < @number@ ) .
Domain scores were calculated for the domains episodic memory , attention and working memory , information processing speed , and executive functioning.
Domain-specific areas for numerical processing were independently localized through a numerosity judgment task.
Domain-specific measures were available for the Newcastle 85 + and the Leiden 85-plus studies.
Do many hands make lighter work for siblings caring for aging parents ?
Do men die young and sick , or do women live long and healthy ?
Dominant cultural narratives need to be challenged by viable counter narratives aimed at repairing and strengthening the moral agency of aging individuals.
Dominant knee extension strength was assessed using an isokinetic dynamometer before and after the intervention.
Dominantly inherited mutations cause less severe disease , which may progress to glucose intolerance and diabetes in later life ( e.g. , SUR1-E1506K ) .
Dominant mutations are found in the domains that have these two enzyme activities , including the common G2019S mutation that increases kinase activity 2-3-fold.
Donepezil has shown some benefit.
Donepezil is an acetylcholinesterase inhibitor approved for use across the full spectrum of mild , moderate , and severe AD.
Donor age may be excluded as a criterion in the guidelines for clinical use of the autologous or allogenic transplantation of hTMSCs.
Donor and recipient diabetes status was determined from existing medical records.
Donor demographics differ substantially between countries ; this can be only partly explained by population demographics and age criteria.
Donor tissue shortage is therefore a growing concern globally and there is a need for alternatives to human donor corneas.
\ "Do not do spot testing with chemical peel agents. \ "
DON quit intentions were aligned with higher odds of facility deficiencies across all domains.
Do older women have the impression they are transmitting or have transmitted something to succeeding generations ?
Door-to-balloon time was similar between those two groups.
Door-to-bed time , time to surgery , mobilisation time , length of stay , and post-operative complications were compared between the OC groups.
Dopamine ( DA ) availability in both striatal and extrastriatal brain regions has been implicated in cognitive performance.
Dopamine ( DA ) losses are associated with various aging-related cognitive deficits.
Dopamine decreases Na-K-ATPase ( NKA ) activity by PKC-dependent phosphorylation and endocytosis of the NKA α1.
Dopamine-mediated regulation of NKA is impaired in aging and some forms of hypertension.
Dopamine neurons contain significant amounts of neuromelanin , and the amount of neuromelanin increases with aging.
Dopamine release deficits are associated with an altered distribution of vesicles in dopaminergic axons in the dorsal striatum.
Dopamine represents a key target in these efforts.
Dopaminergic and noradrenergic therapy is most prevalent among pharmacological methods.
Dopaminergic ( DA ) neuron degeneration is a feature of brain aging but is markedly increased in patients with Parkinson's disease ( PD ) .
Dopaminergic neurons seem to be more sensitive to the loss of mortalin than other neuronal sub-types and non-neuronal tissues.
Dopaminergic transmission plays a critical role in working memory ( WM ) .
Dopamine transporter imaging was abnormal in all parkinsonian patients , indicating Parkinson's disease-like nigrostriatal dopaminergic denervation.
Do participants ' accounts of responses to symptoms , including the decision to consult a physician , incorporate descriptions of change over time ?
Doppler flow and applanation tonometry were performed to assess carotid-femoral pulse wave velocity ( PWV ) and augmentation index ( AI ) .
Doppler flow imaging has been the mainstay of diagnosis.
Doppler measures of LV filling were not enhanced at any condition , irrespective of lifelong exercise frequency.
Doppler showed sensitivity of @percent@ , specificity of @percent@ , a positive predictive value of @percent@ and negative predictive value of @percent@.
Doppler ultrasound has been extensively used in detecting reno-vascular diseases , showing to be a non-invasive , safe , low cost and repeatable tool.
Doppler ultrasound measures of left ventricular ( LV ) active relaxation and diastolic suction are slowed with healthy aging.
Doppler ultrasound measures of LV diastolic filling were assessed at rest and during LV loading ( saline infusion ) to simulate increased LV filling.
Dorsal root ganglion showed mild neuronal loss with a few Nageotte's nodules.
Dorsolateral prefrontal , hippocampus , and putamen volumes negatively correlated with cognitive performance.
Dosages of methotrexate need to be adjusted for creatinine clearance.
Dose distributions are re-created when it is required.
Dose reduction should be made in patients with reduced renal function.
Dose-related clinical findings in animals that died early included thinness , lethargy , abnormal breathing , and ruffled fur.
Dose-response analyses with restricted cubic splines indicate a monotonic inverse relationship between cognitive function and mortality.
Dose results can be corrected for differences in patient weight / age group.
Doses can be titrated at 2-week intervals ( or longer ) to achieve target PLTC.
Dose volume histograms were generated.
Dot displacement ( Δx ) was @number@ @number@ or 30min of arc ; frame duration ( Δt ) was @number@ or 50ms.
Do the elderly undergo semantic degradation of their intuitive biological theory ?
Do the factors include income , health expenditure , the use of mobile telephones , or sanitation ?
Do they have their own specificities ?
Do total de idosos , @percent@ utilizavam pelo menos cinco medicamentos ( polifarmácia ) .
Double-blinded studies involved @number@ patients.
Double-blind studies showed that effective tricyclic antidepressants for the treatment of PHN are amitriptyline and nortriptyline , and effective anticonvulsants gabapentin and pregabalin.
Double Holliday junctions ( dHJS ) are important intermediates of homologous recombination.
Double immunolabeling showed that GFAP-positive reactive astrocytes in the peri-infarct region expressed CSPG , but showed no overlap with ED1-positive activated microglia.
Double immunostaining of an endothelial marker CD34 and vasohibin @number@ with Ki-67 was also performed to assess angiogenic activity of endothelial cells in HCC.
Double immunostaining with K7 and cell proliferation marker Ki-67 was undertaken.
Double-labeled immunofluorescence showed that SSTR1 was mostly co-localized with neurons , and was rarely distributed in activated astrocytes and microglia.
Double-label immunofluorescence revealed that FTL and phospho-PRKDC immunoreactivity colocalized partially with TDP-43 and / or Tau inclusion bodies.
Double mutations were found in only nine HCM patients ( @percent@ ) who were phenotypically indistinguishable from single-mutation carriers.
Double peaked P1 responses were associated with an increase in spectral power in the gamma range.
Double-stranded RNAs ( dsRNAs ) can be generated at various conditions including virally infected cells or UV-damaged skin cells.
Double transgenic mice also showed a decreased level of SOD1 aggregates within the glial cells of the spinal cord.
Doubling dairy product consumption achieved current protein intake recommendations.
Doubtful minor radiographic degenerative features in the knee , however , are a very strong predictor of future KOA.
Douma et al.
Dowling-Degos disease ( DDD ) is an autosomal-dominant genodermatosis characterized by progressive and disfiguring reticulate hyperpigmentation.
DOWN conditions showed the lowest stability in the medial-lateral MoS , but not in LDS.
Down regulated miR-196a2 may be involved in intestinal BD pathogenesis by targeting Bach1 / ho-1.
Downregulating Snail1 by siRNA reduced high glucose-induced EMT in HK2 cells , and miR-30c mimicked the effects.
Downregulation of FAK gene is correlated with downregulation of many angiogenesis-related genes , including Ang1 , VEGFA and Akt.
Down-regulation of Gprc5c led to both moderately reduced glucose-stimulated insulin release and also reduced cAMP content in mouse islets.
Down-regulation of IGFBP5 inhibited PGE ( @number@ ) -induced cellular senescence.
Downregulation of PPARγ coincided with the senescence induction , while its activation inhibited the progression of this process.
Downregulation of rRNA transcription is one major strategy to maintain cellular homeostasis under stress conditions , as it limits energy consumption in disadvantageous circumstances.
Down-regulation of selective autophagy causes similar and non-additive rescuing effects.
Downregulation of SNX27 using RNAi increased Aβ production , whereas overexpression of full-length SNX27 , but not SNX27ΔPDZ , reversed the RNAi-mediated Aβ elevation.
Downregulation of TERRA-bound RBPs by small interfering RNA further shows that they can impact on TERRA abundance , their location and telomere lengthening.
Down-regulation of the chromosomal passenger survivin contributes to these abnormalities , which further result in cell polyploidy.
Downregulation of TRIM25 resulted in an increased acetylation of p53 and p53-dependent cell death in HCT116 cells.
Down's syndrome ( DS ) is characterized by a complex phenotype associated with chronic oxidative stress and mitochondrial dysfunction.
Down's syndrome ( DS ) is the most frequent genetic cause of intellectual disability and is a chromosomal abnormality of chromosome @number@ trisomy.
Down's syndrome ( DS ) , the most common chromosomal disorder , is caused by @number@ trisomy and is featured by intellectual disability.
Downstream effects on protein and metabolite measures are also seen with growing regularity as vital components to this research.
Down Syndrome ( DS ) entails an increased risk of many chronic diseases that are typically associated with older age.
Down Syndrome ( DS ) is characterised by premature aging and an accelerated decline of cognitive functions in the vast majority of cases.
Down syndrome ( DS ) is characterized by genetic instability , neurodegeneration , and premature aging.
Down syndrome ( DS ) is one of the most common aneuploidy.
Down syndrome ( DS ) is the result of triplication of chromosome @number@ ( trisomy @number@ ) and is the prevailing cause of mental retardation.
Down syndrome is caused by partial or complete triplication of genes located on chromosome @number@
Down syndrome is characterized by a number of neurobiological problems resulting in learning and memory deficits and early onset Alzheimer's disease.
Downward or upward mobility of income and wealth were associated with increased hazard of mortality.
Doxazosin improves symptoms better than finasteride both short and long term , with the magnitude of differences ∼2.0 points and @number@ point , respectively.
Doxycycline was the most frequently prescribed antibiotic.
Dozens of people nowadays look for trepanation as a method of spiritualization and increasing well-being and mental power.
DPCs represent physical obstacles to the progression of DNA replication.
DPC without family occurred in @percent@ ( n = @number@ ) of the families analyzed.
DPN patients and healthy age-matched adults over @number@ years performed two 15-second Romberg balance trials.
DPRs could thus provide a way to identify cyclic pamidronate treatment outcomes in patients with OI.
DRAM1 ( DNA damage-regulated autophagy modulator @number@ ) is a TP53 target gene that modulates autophagy and apoptosis.
Dramatic changes concerning sperm motility and morphology must now be considered for the interpretation of standard semen parameters.
Drawing from cumulative inequality theory , the authors analyze trajectories of life evaluations and then consider whether early adversity offsets favorable expectations for the future.
Drawing on Adorno's essay on Beethoven's late style , Said also focuses on the aesthetic aspects of lateness.
Drawing on personal construct theory , Viney ( @number@ ) observes increasing integration of constructions of self with others across the lifespan.
Drawing on Shaw's framework of health behavior and outcomes , a range of beliefs was examined : cause , consequence , continuation , and treatability.
Drawing primarily from human studies , this review summarizes important aspects of aging-related changes in platelets.
Drawing upon a number of established ethical approaches , we examine whether geographic differences in access to livers are inherently unethical.
Drawing upon the multithreat framework , I first provide evidence that this is a self-concept threat and not a group-reputation threat.
DRBDs avidly bind to siRNAs , masking the siRNA anionic negative charge and allowing for efficient PTD-mediated siRNA delivery into the entire cell population.
DREADD stimulation of LC-NE enhanced performance in a novel object recognition task and reduced hyperactivity in Ts65Dn mice , without significant behavioral effects in controls.
Drebrin is a part of the actin cytoskeleton which is a target of numerous bacteria and viruses invading mammalian cells.
Drebrin phosphorylation , self-inhibition and transition between filaments , particles , and podosomes underlie cellular mechanisms involved in diseases and cognitive disorders.
Dr. Hope will outline key issues , as well as her work , relating to defining and measuring quality care in geriatric epilepsy.
Drink frequency moderated the positive association between the Penn State Worry Questionnaire-Abbreviated and insomnia , which was lower with higher frequency of drinking.
Drinking in hazardous situations , blackouts , and tolerance were the most common reported alcohol problems.
Drinking pattern was not significant for other ACSC measures.
Driven by promising preclinical results , several clinical trials are exploring autophagy as a therapeutic target.
Driver assessment and training programs might therefore focus on attention capacity.
Drivers who were ejected , involved in a vehicle rollover , or accompanied by a passenger sitting directly behind them were omitted.
Driving ability in the elderly and cognitively impaired is of growing demographic relevance.
Driving and a lack of transportation to the medical facility were also barriers , particularly for older participants.
Driving cessation in later life is associated with numerous poor health outcomes including limitations in social and physical functioning and increased risk of mortality.
Driving is a highly visual task , and older adults have a high prevalence of vision impairment compared to other ages.
Driving mobility ( frequency , exposure , and space ) was assessed over time.
Driving outcomes included global ratings of safety and the error rate on a standardized on-road test.
Driving represents a complex task for which multiple central resources are needed.
Driving self-restrictions may be better understood as a spectrum across ages in which drivers ' reasons for restriction change.
Driving specific tests were more strongly associated with safety ratings than traditional neuropsychological tests.
Driving status and health characteristics were assessed by self-report.
Driving status data was obtained using a standardized questionnaire.
Driving status was defined on the basis of a driver's license , car ownership , and feeling comfortable to drive.
Drop-in and drop-out artefacts occurred frequently throughout the age groups.
Drop-out rate was not significantly influenced by age.
Dropouts were more frequent for the pharmaceutical-care group than for controls.
DROSHA belongs to miRNA machinery genes and has a central role in initial miRNA processing.
Drosophila macrophages produced the JAK-STAT-activating cytokine upd3 , in a scavenger-receptor ( crq ) and JNK-dependent manner.
Drosophila melanogaster is emerging as a powerful model system for the study of cardiac disease.
Drosophila melanogaster shows a pattern of aging similar to human beings and recapitulates the arrhythmogenic conditions found in the human heart.
Drosophila miR-1000 showed activity-dependent expression , which might serve as a mechanism to allow neuronal activity to fine-tune the strength of excitatory synaptic transmission.
Dr. Polder is a principal investigator and Dr. Suzanne Bruce is a consultant for Solta Medical.
DRPs identified by each set of criteria were recorded.
Dr. Toni Calasanti has postulated that there are gender differences in the care work styles and coping strategies used by spousal caregivers dealing with dementia.
Drug addiction among elderly often reflects the drift of \ "lawful \ " doctor's instructions that leads to an increase in drugs use.
Drug addiction is often underestimated among the aged.
DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.
Drug availability of ketamine and xylazine was @number@ and @number@ times greater , respectively , in old than young rats.
Drug classes were divided into thromboxane A2 inhibitors , vitamin K factor-dependent inhibitors , antithrombin III activation , platelet P2Y12 inhibitors , and thrombin inhibitors.
Drug costs with and without prescribers ' behavioral changes were estimated.
Drug development efforts for AD have been encumbered by largely unsuccessful clinical trials in the last decade.
Drug development for psychiatric disorders has almost ground to a halt.
Drug discovery based on nutraceutical molecules for prevention and treatment of AD is a growing topic.
Drug discovery efforts are being increasingly centered on these stem cells , boosting the hair cycle and reversing miniaturization of HF.
Drug discovery is identifying novel molecules that target underlying disease mechanisms.
Drug-drug interactions and polypharmacy are widespread due to the number of medications older adults consume.
Drug-drug interactions between these agents and other drugs commonly used in the elderly population are also considered.
Drug-drug interactions should be considered in antibacterial choice.
Drug-drug interactions were frequent ( @number@ requiring medical attention ) , up to five for each single patient.
Drugeluted and bare-metal stents had been placed in @number@ and @number@ patients.
Drug eluting stents have lately been criticized for increased reports of very late stent thrombosis.
Drug-eluting stents , which require a double antiaggregative therapy for @number@ months after positioning , formally exclude patients from day surgery for that period.
Drug-induced refractive disorders resolve after treatment cessation.
Drug metabolism varies among individuals with different microbial communities , so age- and region-specific clinical trials are required to ensure safety and efficacy.
Drug-multimorbidity interactions are not sufficiently investigated and understood.
Drug reactions may have significant downstream consequences for the older individual.
Drug reduction for sedation and analgesia and non-pharmacological approaches are recommended.
Drug release from the gel followed non-fickian mechanism with @percent@ of drug released in @number@ hr.
Drug release in both cases was found to follow the Higuchi square root model.
Drugs acting on cardiovascular ( CV ) prevention are , by definition , interconnected with age-induced arterial changes.
Drugs approved for the treatment of AD include tacrine , donepezil , rivastigmine , galantamine , and memantine.
Drugs at baseline were categorised using the American Geriatrics Society @number@ Beers criteria.
Drugs currently used for the treatment of AD produce limited clinical benefits and do not treat the underlying causes of the disease.
Drugs in the pipeline include symptomatic therapies that are neurotransmitter-based , but mostly disease-modifying therapies.
Drugs play a role in the pathogenesis of erectile dysfunction , as they can alter hormonal or vascular mechanics needed for achieving or maintaining erection.
Drugs specifically targeting TERRA molecules could modulate telomerase-mediated telomere lengthening.
Drugs that activate SIRT1 may offer a promising approach to treat these disorders.
Drugs that interfere with the cascade of events that eventually lead to neutrophil influx are potential antiphotoaging agents.
Drugs that modify the risk of dementia in the elderly are of potential interest for dementia prevention.
Drugs used for dementia and dementia syndromes provoked particular response heterogeneity.
DRUGS was the instrument most often used.
DRUGS ( which uses the real regimen taken by the elderly ) was the most widely used assessment instrument in the screened studies.
Drugs without a strong evidence base and outside of recommendations are too often prescribed for older adults.
Drugs with poor aqueous solubility have difficulty dissolving in the GI tract , resulting in low bioavailability.
Drug therapies are symptomatic and inadequate to contrast disease progression and mortality.
Drug transporters play an important role in pharmacokinetic processes , but their function and pharmacology have not yet been fully examined for agerelated effects.
Drug underuse , misuse and abuse are described , together with criteria to manage perioperative medications.
Drug use increases with age and the elderly is at increased risk of adverse drug reactions.
Drug users with HIV infection successfully treated with highly active antiretroviral therapy are now living to older ages.
Drug use severity fully mediated the relationship between emotional distress and readiness.
Drug withdrawal might be considered in the management of epilepsy despite the persistence of epileptiform abnormalities.
Drusen and basal laminar deposits were intensely positive for CRP and CFH.
Drusen is a pathological feature that is well-associated with AMD.
Drusen score covariates were associated with the R1210C rare variant.
DR was graded using a modification of the Early Treatment of Diabetic Retinopathy Scale.
Dry eye and dry mouth symptoms are each reported by up to @percent@ of persons more than @number@ years of age , particularly in women.
Dry eye disease ( DED ) is a common disease that can impair quality of life significantly.
Dry eye disorders are becoming more common due to many causes , including an aging population , increased pollution , and postrefractive surgery.
Dry eye in humans displays increased prevalence in the aged and in women.
Dry eye syndrome is a common irritating eye disease.
Dry eye was determined by self-report of frequency of symptoms and the intensity of those symptoms.
Dry skin can worsen if management is inappropriate or lacking.
Dry skin is a common problem in the older individual due to physiological changes of the aging process as well as chronic health conditions.
Dry skin is characterized by a decreased lipid content and a delayed reconstitution of the epidermal barrier after skin irritation.
Dry skin , or xerosis , is a common skin condition in older adults , but it is not a normal part of aging.
DSB levels can be obtained either by measuring overall γ-H2AX protein levels in a cell population or by counting γ-H2AX foci in individual nuclei.
DSCSA and SCCSA have been ideal morphological parameters for evaluating LCCSS.
DSCSA and SCCSA were previously correlated with subjective walking distance before claudication occurs , aging , and disc degeneration.
DS has been called a mature well-understood syndrome , not in need of further research or science funding.
DS is phenotypically manifested by premature aging , upward slant to the eyes , epicanthus , flattened face , and poor muscle tone.
DSM-5 mild NCD overlapped with @percent@ of MCI cases and resulted in a @percent@ increase in diagnosis.
DS microbiome was compared with that of age-matched healthy non-trisomic adults enrolled in the same geographic area.
DS-related WM integrity reductions in a number of tracts were associated with poorer cognition.
DSS analysis was supported by a Simple Multivariable Cox Proportional Hazard Regression of all significant variables studied.
DSST score and serum cystatin C can thus provide evidence-based tools for geriatric assessment.
DSs were assessed using the severe depression subscale of General Health Questionnaire @number@
DSWL are used by @time@ % of the examinees.
DTA was notably lower for all other index tests.
DTI- and DBSI-derived fractional anisotropy ( FA ) maps were processed with tract-based spatial statistics for comparison between both groups.
DTI and NODDI revealed widespread increases in isotropic diffusivity with increasing age.
DTI and spectroscopy protocol performed in the femoral neck could be highly sensitive and specific in identifying healthy subjects.
DTI and T1-weighted data were acquired at 3T on @number@ healthy males and @number@ age-matched females aged 18-59 years.
DTI-based index of diffusivity is complementary to macrostructural gray matter changes in the hippocampus in detecting prodromal AD.
DTI data were analyzed for small-world parameters , modularity , and the number of fiber tracts at the level of streamlines.
DTI data were collected from @number@ AD patients , @number@ MCI subjects and @number@ healthy controls.
DTI-derived FA was lower in HIV + compared with HIV- individuals.
DTI estimates remain among the most sensitive markers for age-related alterations in white matter.
DTI fractional anisotropy ( FA ) brain maps were generated and selected cognitive tests were administered.
DTI was performed on @number@ subjects ( age : 10-52 years ) .
DTP was estimated using a validated Food Frequency Questionnaire and our own polyphenol database.
DTT was significantly shorter for patients who healed ( p < @number@ ) .
Dual energy X-ray absorptiometer measured bone mineral density ( BMD ) of ovariectomized Sprague Dawley rats that had been fed olive oil for @number@ months.
Dual-energy X-ray absorptiometry , anthropometry , resistance , reactance , and other independent predictive variables were assessed.
Dual energy X-ray absorptiometry ( DXA ) and BIA were performed in both cohorts.
Dual-energy X-ray absorptiometry ( DXA ) -derived indices may alleviate these problems and provide useful alternative assessments.
Dual-energy X-ray absorptiometry ( DXA ) was used to measure the whole and regional body composition.
Dual-energy X-ray absorptiometry measured lean soft tissue mass.
Dual-energy X-ray absorptiometry was used to analyze total and segmental body composition.
Dual-energy X-ray absorptiometry was used to measure the lumbar BMD of the two groups before and after the intervention.
Dual energy X-ray absorptiometry was utilized to evaluate bone mineral density ( BMD ) .
Dual-immunolabeling of Tie1 with specific markers of endothelium and smooth muscle and Ang1 and Ang2 was performed.
Dualistic notions about gender and sexuality have permeated the field of couple and family therapy.
Dual labeling with antibodies against phospho-Ser @number@ and nitrated α-synuclein revealed only limited colocalization and mostly stained distinct sub-populations of dopaminergic neurons.
Dual-luciferase reporter gene assays revealed that promoter fragments of OPRK1 and OPRM1 were able to upregulate gene expression.
Dually enrolled Medicare-Medicaid older adults are a vulnerable population.
Dual-modal imaging techniques have gained intense attention for their potential role in the dawning era of tumor early accurate diagnosis.
Dual-process theories posit that two separate processes are involved in recognition , namely recollection and familiarity.
Dual regression was used to obtain participant and task specific time-courses per IC.
Dual sensory impairment ( DSI ) was defined as presence of both impairments.
Dual system theories suggest that behavioral control is parsed between a deliberative \ "model-based \ " and a more reflexive \ "model-free \ " system.
Dual-task costs ( DTC ) on SAT , cadence , and overall DTC were measured for each of these tasks.
Dual-task costs for both cognitive and timing performances were pronounced at slower tapping tempos , an effect exacerbated in older adults.
Dual task costs for both walking and cognition were computed.
Dual-task costs on gait speed were greater in slow-walking older adults than fast walkers.
Dual-task designs have been used widely to study the degree of automatic and controlled processing involved in postural stability of young and older adults.
Dual-task gait variability decreased ( ie , improved ) and Trail Making Test times ( parts A and B ) improved.
Dual tasking appears to influence kinematic gait variables in a manner consistent with promotion of stability.
Dual-tasking is a common activity of daily living ; this work provides insight into the age-related changes in postural stability and attention demand.
Dual tasking resulted in increased sway speed and area but reduced complexity ( P < @number@ ) .
Dual tasking studies may be a useful way to explore and understand the relation between cognitive and physical frailty.
Dual-task interference on both reaction time and movement time were significantly predicted by low working memory capacity in female PM carriers.
Dual-task measures and subjective ratings tap different aspects of listening effort.
Dual tasks were applied to appraise improvements of cognitive processing during balance and gait.
Dual-task timing was characterized by shortening of produced intervals and increases in drift and variability.
DU can be diagnosed at present only on the basis of an invasive urodynamic study.
Duchenne muscular dystrophy ( DMD ) is the most common form of the progressive muscular dystrophies characterized by defects of the dystrophin gene.
Ductular reaction at the limiting plate , mean number of isolated progenitor cells ( IPC ) and isolated ductular structures ( IDS ) were quantified.
Due to a consistent pattern of alteration of bone mass distribution in the sacrum , other fracture morphologies occur than in younger adults.
Due to advances in medicine in the past few decades , life expectancy has increased resulting in an aging population in developed and developing countries.
Due to advances made in HIV treatment , the population of individuals with HIV over the age of @number@ is growing.
Due to aging and degenerative disease , circadian rhythm gradually collapses.
Due to aging of the population , the incidence of this type of fracture is gradually and constantly increasing.
Due to an ageing population across the world , older people now constitute a significant proportion of those at risk from disasters.
Due to an aging population it is of interest to determine whether NT-proBNP can predict cardiac events with equal precision in subgroups with different ages.
Due to an aging population , the incidence of dementia is steadily rising.
Due to an increase in population number and the aging population demographic there is an increasing stress being placed on current healthcare systems.
Due to cognitive decline that accompanies normal aging , older adults might have difficulties in some aspects of FDM.
Due to complexity of care , health care professionals face challenges in providing effective case management and avoiding unplanned admissions to hospital.
Due to continuing development of brain and behavior , stability of temporal discounting behavior in adolescence may differ from that in adulthood.
Due to demographic changes , an increasing number of elderly patients presents with cerebrovascular hemodynamic insufficiency.
Due to demographic changes , including population growth and aging , the cumulative burden of oral conditions dramatically increased between @number@ and @number@
Due to diet being modifiable , demonstrating the effects of nutrition on bone health can provide an approach for osteoporosis prevention.
Due to dissimilarity of many areas of nursing work and unique features of every age group , specialized and aligned scales are needed.
Due to effect modification by age , all analyses were conducted using a piecewise model for age.
Due to expanding clinical indications and an aging society there has been an increase in the use of implantable pacemakers.
Due to experimental limitations with clinical trials , an additional animal experiment was performed.
Due to functionally distinct cell-mediated immunity , newborns and infants are highly susceptible to infection with intracellular pathogens.
Due to genome-scaled polygenic adaptation , the large target effect also contributes to our inability to identify adapted behavioral candidate genes.
Due to improved diagnostic methods and population aging , CKD is diagnosed ever more increasingly.
Due to improved surgical technologies and post-operative care , long-term survival has improved in patients with congenital heart disease.
Due to improvements in socioeconomic development and increased life expectancy , the proportion of older people in the general population is increasing worldwide.
Due to increased life expectancy in a growing world population , the impact of ageing on the pathophysiology of cardiovascular diseases will increase.
Due to increases in attentional requirements of upright stance in older adults , it is unclear if similar benefits would be observed in this population.
Due to its accessibility and simplicity , the retina has become an invaluable model for studying the basic mechanisms involved in development.
Due to its extensive length , DNA is packaged into a protective chromatin structure known as the nucleosome.
Due to its frequency , there is a strong clinical need for treatment alternatives to dopaminergic drugs.
Due to its influence in cell growth pathways Cdc37 has attracted much attention as a potential intermediate in carcinogenesis.
Due to its inherent amyloidogenicity S100A9 contributes to amyloid plaque formation together with Aβ.
Due to its many characteristics , the VR allows to solve several limitations of the traditional tests.
Due to its particular watershed vascularization , these brain networks are highly susceptible to microvascular damage and the effects of vascular risk factors.
Due to its propensity to aggregate and to be expressed at low levels , studies comprising authentic gp41 produced in eukaryotic cells are extremely rare.
Due to its structure presenting many similarities with the other proglucagon-derived peptides , its measurement is technically challenging.
Due to its structure , the OLSa seems to be a useful tool for determining IM.
Due to lack of drugs having endometrium receptivity enhancement properties , oocyte donation seems to be the only solution for women with implantation failure.
Due to life-enhancing effects of antiretroviral therapy , HIV-positive persons have the potential for long life comparable to their uninfected peers.
Due to limited feedback to users opportunities to self-manage were reduced.
Due to low attendance rate @number@ subjects were excluded from the analyses.
Due to low numbers of deaths , we smoothed the ASMRs using a 3-year moving average.
Due to many reasons , the insulin / insulin-like growth factor-1 ( IGF-1 ) has been considered as a key pathway in aging research.
Due to multiple actions on both osteoblasts and osteoclasts , RES has potential to attenuate bone loss resulting from different etiologies and pathologies.
Due to numerical differences , each test requires its own set of reference values.
Due to pharmacodynamic changes , therefore , dose adjustment of the above mentioned cardiovascular and psychotropic drugs is recommended in elderly.
Due to pharmacoepidemiological disequilibrium , unchanged model parameters would imply an increase of @percent@ , ageing alone @percent@.
Due to polyetiology of the disease , sildenafil is regarded as the gold standard of treatment , and new high quality generic drugs are marketed.
Due to potential complications and the progress in surgery with regards to maintaining sexual function a cystectomy should be offered to young patients.
Due to potential severe consequences , a systematic evaluation of autonomic regulation should be performed in order to avoid dramatic events.
Due to prohibitive surgical risk , many patients are not candidates for surgery.
Due to relentless disease progression , a good functional and aesthetic result seems to require selected techniques and repeated surgery.
Due to safety concerns , transient expression of TERT mRNA may be preferred for tissue engineering and adoptive stem cell therapy.
Due to severe loss of leg strength old adults are required to change the way they rise from a chair and maintain stability.
Due to the advent of antiretroviral therapy HIV is no longer a terminal disease and the HIV infected patients are becoming increasingly older.
Due to the aging and increasingly complex nature of our patients , frailty has become a high-priority theme in cardiovascular medicine.
Due to the aging population , the number of elderly patients taking advantage of healthcare services is increasing.
Due to the aging population , the number of patients treated with aortic grafts or endografts continues to increase.
Due to the complexity of the individual patient , no guidelines have been yet established.
Due to the connection between chronic inflammation and these diseases , it is essential to understand underlying mechanisms behind this process.
Due to the cosmetic nature of such formulations , evidence of their clinical efficacy and mechanism of action is often limited.
Due to the cross-sectional design of the current study , the potential associations between androgen levels and actual future cardiovascular events could not be assessed.
Due to the current rise in the aging population , the prevalence and impact of Alzheimer's disease are expected to increase greatly.
Due to the demographic change hospitals will be more and more dependent on the work ability and performance of an aging workforce.
Due to the development of new microscopy and cataract phacoemulsification techniques , we have more choices of surgical method.
Due to the heterogeneity of cardiomyopathic patterns and symptoms , their diagnosis and therapies are great challenges.
Due to the heterogeneity of patient outcomes , it is important to investigate early markers of future ability to provide effective and targeted intervention.
Due to the increase in the size of the aging population , this trend is predicted to continue.
Due to the increasing proportion of older people in the general population epidemiologists are interested in identifying which factors determine healthy ageing.
Due to their high iron content , the DCN are visible as hypo-intensities.
Due to their potential to increase exercise tolerance in healthy individuals , SIRT1 activators are currently being monitored by anti-doping authorities.
Due to their relevance in cellular physiology , defects in mitochondria are associated with various human diseases.
Due to their young age at transplantation , most pediatric recipients eventually require retransplantation , and the optimal order of donor type is not clear.
Due to the large diversity in the individual diurnal fluctuations , a significant diurnal variation of choroidal thickness was not observed.
Due to the limited activity of antioxidant and repair mechanisms , levels of reactive oxygen species can increase during aging.
Due to the loss of elasticity of the vessel wall , vascular calcification might result in left ventricular hypertrophy and compromise coronary perfusion.
Due to the low sequence similarity with other typical kinases , structure-activity relationships of this enzyme remain unclear.
Due to the menopause-related hormonal changes , women in most western countries live more than one-third of their lives in postmenopausal status.
Due to the methodology of the procedure , the experimental group was randomly divided into three groups.
Due to the myriad factors straining China's traditional family-based eldercare system , today unprecedented numbers of older adults are turning to institutions for caregiving needs.
Due to the paucity of data , we believe that the true prevalence of asthma may still be under-estimated.
Due to the presence of a common set of behavioral and cognitive symptoms , differential diagnosis may become arduous.
Due to the presence of mitochondrial disturbances , A-T , BS and NBS may be considered mitochondrial diseases.
Due to the progression of aging in Japan , pharmacists need to participate in home medical care.
Due to the rapid aging of the population , it has become important to ensure the provision of primary health care services.
Due to the reform of long term care in @number@ there is growing concern about whether groups at risk receive the care they need.
Due to the scarcity of literature , recent reports of facial lifting using threads were also selected , complemented with bibliographical references.
Due to the scarcity of studies on each topic and inconclusive findings , no clear patterns of results emerged.
Due to the small size of the sample , TPNB may present limited usefulness for classical pathology diagnostics.
Due to the spectrum of the amino acid changes , we suggest that loss of function in TGDS is the underlying mechanism of Catel-Manzke syndrome.
Due to the unprecedented increase in the United States aging demographics , many more people are living longer and reaching older ages than ever before.
Due to the vast variability in the types and severity of trauma , the cellular consequences of head injury are not completely understood.
Due to the Warburg effect and increased oxidative stress , cancer cells frequently accumulate significant amounts of AGEs.
Due to the world-wide aging population , there is a need for specialist neurological knowledge , treatment and care.
Due to this semi-coincidence , senescence is confused with cell cycle arrest , or even more misleadingly , with growth inhibition.
Due to various factors , older people are potentially vulnerable groups at risk of malnutrition.
Due to vital functions that keep photoreceptors healthy , the RPE is essential for maintaining vision.
Dunal ) has long been used in the traditional Ayurvedic system of medicine to enhance memory and improve cognition.
Dunal ) in improving memory and cognitive functioning in adults with mild cognitive impairment ( MCI ) .
Duplications at this locus were not found in control individuals.
Durable clinical responses have also been demonstrated in mantle cell lymphoma ( MCL ) and Waldenström's macroglobulinemia ( WM ) patients treated with ibrutinib.
Durable memories were associated with greater encoding activity in inferior lateral parietal and posteromedial regions and greater retrieval activity in frontal and insular regions.
Dural calcification , and granulation in the ear drum and external ear canal were additionally observed.
Duration and timing of systemic chemotherapy before liver resection should be optimized to minimize postoperative morbidity.
Duration and updated measures over the course of the follow-up to address short-term effects were also considered.
Duration difference limens in milliseconds for increments of a single sequence IOI were measured adaptively by adjusting the duration of an inter-tone silent interval.
Duration DLs in ms for increments of a single sequence IOI were measured adaptively by adjusting the duration of the silent interval between two tones.
Duration of action was beyond the clamp duration of @number@ h in all subjects.
Duration of delirium was also associated with lower Awareness Questionnaire Motor / Sensory Factors scores ( p @number@ ) .
Duration of driving anxiety was highly variable , from relatively recent onset to being present for much of some participants ' lifetimes.
Duration of e-cig activation was inversely related to NNR ( NNR = @number@ with 3-s activation , @number@ with @number@ s ) .
Duration of epilepsy ( years ) was not related to IQ , memory , or language scores in any group.
Duration of overall effect varied among the patients.
Duration of supplementation for the @number@ trials range from one to @number@ years ( median = @number@ years ) .
Duration of treatment was between @number@ and @number@ days for cSSTIs without bacteraemia and between @number@ and @number@ days for cSSTIs with bacteraemia.
Duration of working time was significantly associated with micronucleus frequency , Comet tail length and relative telomere length.
During 12-month follow-up , all of the ulcers healed except one.
During 1958-2012 , NASA spent $ 800 billion.
During 1991-2005 , an estimated @number@ @number@ cancers occurred in the AIDS population.
During 2008-2009 we enrolled @number@ subjects in the Abruzzo / Marche regions , Italy.
During 2015-2030 , there are projected to be nearly @number@ excess liver deaths.
During a 1-year follow-up period , @number@ patients died ( @percent@ in the young group vs. @percent@ in the elderly group ) .
During a 1-year follow-up , the nonfall group ( baseline study ) was assessed for the same measurements by using the same methods.
During a 7-day pre-trial period , @number@ patients dropped out ( @number@ and @number@ in the probiotic and placebo groups respectively ) .
During accommodation , changes to ciliary muscle thickness and length remained constant throughout life.
During ACh perfusion , SkBF ( P = @number@ ) and RSR were similar between groups ( P = @number@ ) .
During a community-based longitudinal study on aging , we detected tau pathologies not compatible with these categories.
During active listening decrease of theta- and gamma-frequency range activities occurred with increasing expertise in right posterior regions , possibly reflecting enhanced processing efficiency.
During active regulation , older individuals showed greater drops in negative affect and inverse rostrolateral prefrontal-amygdala connectivity.
During active VL , the two groups were similar in all immunological parameters , including the parasite load.
During adolescence , considerable social and biological changes occur that interact with functional brain maturation , some of which are sex-specific.
During adolescence , WM microstructure reached adult levels , including frontocortical , frontosubcortical and cerebellar connections.
During a follow-up period of @number@.2±1.4 years , there were @number@ ( @percent@ ) composite events.
During a follow-up period ranging from @number@ to 24months , all patients ate normally without vomiting and abdominal distension and grew normally.
During ageing , a general deregulation of metabolism occurs , affecting molecular , cellular and physiological activities in the organism.
During ageing all tissues , including skeletal muscle , demonstrate an accumulation of oxidative damage that may contribute to loss of tissue homeostasis.
During ageing and in several diseases , muscle wasting occurs.
During ageing , microglia acquire a phenotype that may negatively affect brain function.
During ageing-related atrophy , myonuclei are not lost but an unequal distribution is reported.
During aging , a decline in stem cell function is observed in many tissues.
During aging , AGEs accumulate in extracellular matrix proteins like collagen and contribute to vessel stiffness.
During aging and inflammatory-related diseases , the collagen network undergoes oxidation that leads to structural and biochemical alterations within the collagen molecule.
During aging and in neurodegenerative diseases components of this PQC system , including Lon protease present in the mitochondrial matrix , become functionally impaired.
During aging and in the progression of Alzheimer's disease ( AD ) , synaptic plasticity and neuronal integrity are disturbed.
During aging , cells secrete molecules called senescence-associated secretory phenotype ( SASP ) .
During aging , crystallins , the major intra-cellular structural proteins of the lens , aggregate and become water-insoluble.
During aging declining maximum force capacity with more or less unchanged fatigability is observed with the underlying mechanisms still not fully understood.
During aging , decreased miR-18 / 19 and increased CTGF and TSP-1 levels identify the failure-prone heart.
During aging , dermal collagen fibrils undergo progressive loss and fragmentation , leading to thin and structurally weakened skin.
During aging , experimental and clinical studies support the pivotal role played by reactive oxidant species in the mechanism of platelet activation.
During aging , increases in the number of senescent cells are seen in various tissues.
During aging , loads decrease to a greater extent at those skeletal sites where loads increase most in earlier life.
During aging , many tissues show a decline in regenerative potential coupled with a loss of stem cell function.
During aging , multiple changes involving physical , chemical , and biochemical processes occur from the molecular to the morphological levels in neural tissues.
During aging , NSCs become depleted and dysfunctional , resulting in reduced neurogenesis and poor brain repair.
During aging , oxidative stress affects the normal function of satellite cells , with consequent regeneration defects that lead to sarcopenia.
During aging , progressive deleterious changes increase the risk of disease and death.
During aging , reduced responsiveness to FGF diminishes satellite cell self-renewal , leading to impaired skeletal muscle regeneration and depletion of satellite cells.
During aging , telomere shortening correlates with tissue dysfunction and loss of renewal capacity.
During aging the cell turnover rate declines for several highly-mitotic tissues.
During aging , the human skin reveals some apparent modifications of functionalities such as a loss of elasticity.
During aging the immune system of the brain undergoes multiple structural and functional changes.
During aging , the proteins , lipids , and mitochondria within the ICNs become damaged in a process exacerbated by UV light.
During aging , the retina suffers from a low-grade chronic oxidative insult , which sustains for decades and increases in level with advancing age.
During aging , uncontrolled epithelial cell proliferation in the uterus results in endometrial hyperplasia and / or cancer development.
During a long time , it was considered as the consequence of aging and mechanical stress on cartilage.
During a mean follow up of @number@ months , @percent@ required repeat revascularization and @percent@ died.
During a mean follow-up of @number@ years , @number@ cases of AF were reported.
During a mean follow-up of @number@ years , there were @number@ major vascular events.
During a mean follow-up of @number@ years there were @number@ new cases of HF.
During a mean follow up of @number@ y , @number@ men ( @percent@ ) developed DM.
During a median follow up of @number@ ( @date@ @number@ ) years , @number@ participants developed HF.
During a median follow-up of @number@ ( @date@ @number@ ) years , @number@ ( @percent@ ) participants developed HF.
During a median follow-up of @number@ months , @number@ ( @percent@ ) patients sustained a hemorrhagic stroke.
During a median follow-up of @number@ years after HF onset , @percent@ participants died.
During a median follow-up of @number@ years , a total of @number@ new cases of HF occurred.
During a median follow-up of @number@ years , @number@ individuals died , @number@ of them ( @percent@ ) for CV causes.
During a median follow-up of @number@ years , @number@ patients ( @percent@ ) died and @number@ patients ( @percent@ ) received a heart transplant.
During a median follow-up of @number@ years , @number@ ( @percent@ ) subjects developed ESRD.
During a median follow-up of @number@ years , there were @number@ cases of incident dementia in the participants with complete data.
During a median follow-up time of @number@ years , only @percent@ of patients underwent CRC screening.
During a median [ IQR ] follow-up time of 36months , @number@ ( @percent@ ) stroke / TIA events were recorded.
During a median @number@ years of follow-up , @number@ of @number@ study participants died ( @percent@ ) .
During a median of 17·4 years of follow-up , @number@ people died.
During a median of @number@ years of follow-up , @number@ cases of incident AF occurred.
During amino acid abundance increased activity of mTORC1 drives protein synthesis and growth.
During anagen melanocyte precursors migrate to the hair bulb to form the pigmentary unit where they mature and synthesize melanin.
During and after the conference , the lists were circulated among the participants and revised to reach a consensus.
During anesthesia for a Japanese acatalasemic patient the disinfection with hydrogen peroxide solution caused severe methemoglobinemia.
During an inflammatory response , lymphocyte recruitment into tissue must be tightly controlled because dysregulated trafficking contributes to the pathogenesis of chronic disease.
During an overall mean of @number@ ( @number@ ) y , there were a total of @number@ incident prostate cancers and @number@ total cancers documented.
During apoptosis signaling , caspase-2 rapidly homodimerizes , which leads to its activation and proteolytic processing.
During a postural perturbation , as head angular velocity increased , stepping responses were delayed.
During both single- and dual-task conditions , we found that older adults had greater brain activation relative to younger adults.
During brain development , the oligodendrocytes may use lactate as an alternative source of energy and material for myelin formation.
During BR formation markers were reduced only in younger men whereas resorption markers increased to a comparable extent.
During cell senescence , nuclear alterations also involving NE architecture are widely described.
During cellular differentiation and aging , both systems are subject to extensive changes that significantly affect their proteolytic activity.
During centrifugation , the supine subjects were exposed to AG in the head-to-feet direction with @number@ G at the center of mass.
During chemical transmission , the function of synaptic proteins must be coordinated to efficiently release neurotransmitter.
During childhood , 39 / 46 ( @percent@ ) had sleep disorders , which improved in 27 / 39 ( @percent@ ) over the years.
During childhood , 42 / 46 ( @percent@ ) had seizures , which improved over the years in all subjects.
During cognitive debriefing , the majority of patients in both groups agreed the instrument was understandable , comprehensive , and easy to complete.
During conventional ex vivo expansion , a large portion of MSCs lose the properties that make them attractive for use in cell therapies.
During covert evaluation the gait pattern was modified in all groups.
During delayed recall , primacy performance was related to the bilateral supramarginal gyri.
During dental treatment sessions , patients were told to rinse their mouth with whichever cup they preferred.
During development , neuronal death is the major factor shaping the nervous system.
During division of normal somatic cells p27 is removed by cyclin E-Cdk2 complex.
During DNA replication , nucleosomes ahead of replication forks are disassembled to accommodate replication machinery.
During each morning session , two blood samples were collected , and subjective feelings of alertness were completed three times.
During each testing session , transcranial magnetic stimulation was used to generate motor evoked potentials ( MEPs ) and silent periods in the tibialis anterior.
During each trial , subjects rated pain intensity continuously using an electronic visual analogue scale ( 0-100 ) .
During early intervention , curcumin decreased fecal fat , but at later stages , it increased fat excretion.
During embryogenesis short fibrils are produced but they grow rapidly with maturation.
During embryonic and fetal growth , muscle progenitor cells provide the source for muscle growth.
During embryonic development the survival and cholinergic phenotype of brainstem autonomic neurons is promoted by brain-derived neurotrophic factor ( BDNF ) .
During embryonic stages , Cajal-Retzius cells derived from the cortical hem co-express p73 and p63.
During endothelial dysfunction or under pathological conditions , ROS / RNS production increases and the platelets respond with specific biochemical and morphologic changes.
During expansion , their proliferative capacity was examined.
During facial aging , these fat-filled compartments undergo substantial changes along with other structures in the face.
During fasting , higher urinary epinephrine concentrations correlated with smaller reductions in EE ( ρ = @number@ P = @number@ ) .
During fetal development , blood vessels penetrate deep within the AF and recede during postnatal growth.
During follow-up ( 1981-2013 ) , @number@ participants died ( median age at death , @number@ years ) .
During follow-up , abdominal pain completely relieved.
During follow-up , all events occurring between two visits , in particular hospital admissions or nursing home placements were carefully recorded.
During follow-up , biomarker levels significantly increased.
During follow-up calls , many patients reported feelings of loneliness and social isolation post-discharge.
During follow-up ( median : @number@ years ) , we assessed vital status , cause of death and therapy details.
During follow-up , @number@ individuals ( @number@ men and @number@ women ) developed a new fracture.
During follow-up , @number@ men developed incident MetS , while @number@ men did not develop MetS.
During follow-up , @number@ men ( @number@ % ) died.
During follow-up ( @number@ ± @number@ months ) , @number@ of these patients were re-examined.
During follow-up , @number@ participants developed dementia ( @number@ with AD ) .
During follow-up , @number@ participants transitioned to AD dementia.
During follow-up , @number@ ( @percent@ ) patients experienced an IR , @number@ ( @percent@ ) a VR , and @number@ ( @percent@ ) died.
During follow-up @number@ ( @percent@ ) were admitted to hospital with a first incident hip fracture.
During follow-up , @number@ subjects ( @percent@ ) experienced falls.
During follow-up , @number@ total incident CVD , @number@ incident MI cases , and @number@ incident ischemic stroke events were identified.
During follow up , @percent@ ( 131 / 453 ) died within the mean of @number@ ± @number@ days.
During gait the body is in a continuous state of imbalance , with each subsequent step preventing a fall.
During HDT , heart rate ( HR ) was reduced for -25° and -55° , and cardiac output was lower at -55° HDT.
During heat stress , RVP reaction time improved ( P < @number@ ) in both groups.
During her stay , she did not attend classes nor leave the facility unless on the South Bay bus with the other assisted living residents.
During homeostasis , the majority of Nrf2 is degraded in the cytoplasm by ubiquitin ( Ub ) -mediated degradation.
During hospitalization clinical data , including dietary intake and presence of a DC were obtained.
During hospital stay older patients are at an increased risk for AEs.
During human joint aging , expression of FOXO1 and FOXO3 was markedly reduced in the superficial zone of cartilage regions exposed to maximal weight bearing.
During inflammation , according it stages , macrophages change functional state , switching from cytotoxical M1 to M2 , that associated with reparation.
During juvenile growth cellular proliferation and apoptosis are well balanced , which may be perturbed upon aging.
During last century mortality due to infections and injuries has gradually decreased and a longer life expectancy increased a rate of chronic diseases.
During later life sleep depth ( slow-wave sleep , SWS ) and maintenance exhibit deleterious changes , with possible negative effects on daytime function.
During life , iron accumulates in the brain , predominantly in the globus pallidus and in the substantia nigra.
During localization and deployment of the stent graft , hypotension was induced by RACP or intravenous SNP , according to randomization.
During mammalian development , migration , proliferation and survival of primordial germ cells can give rise to germ stem cells.
During mean follow-up of @number@ years , @number@ nonfatal and fatal CHD events were observed.
During menopause , decline in circulating estrogen is coincident with decline in brain bioenergetics and shift towards a metabolically compromised phenotype.
During menopause , women experience a variety of predictable symptoms and conditions related to changes in sex hormone levels and aging.
During MI , ERD% and HbR concentration were less lateralized in older adults than in younger adults.
During movement , increasing age was associated with increased MRBD amplitude in ipsilateral M1 and reduced frequency ( in contralateral and ipsilateral M1 ) .
During neonatal spermatogenesis , cyclin K is highly expressed in gonocytes and spermatogonial stem cells.
During neuronal development , the SIR2 ortholog SIRT1 is structurally important , promoting axonal elongation , neurite outgrowth , and dendritic branching.
During normal ageing , this daily coordination gradually erodes , and during pathological ageing such erosion is exacerbated.
During normal aging and in AD , cell loss is not as prominent a phenomenon as is often presumed.
During normal aging , widespread loss of nerve cells does not occur.
During normal walking , muscle co-contraction increases with gait speed in young adults , but not in elderly adults.
During NREM sleep , patients showed a clear decrease in the relative power of delta band.
During @number@ million person-years of follow-up , @number@ incident cases were identified.
During @number@ person-years , @number@ incident diabetes cases occurred.
During @number@ person-years of follow-up , @number@ deaths occurred.
During @number@ person-years of follow-up , @number@ participants developed fatty liver on ultrasound examination.
During @number@ to @number@ femur fractures were newly diagnosed in @number@ patients among @number@ enrollees.
During @number@ years of follow-up , @number@ men died.
During @number@ years of follow-up , @number@ participants ( @percent@ ) developed mobility limitations.
During osteoclastogenesis , its expression is downregulated at the transcriptional level via the JNK and p38 MAP kinase pathways.
During phase @number@ we assessed ad libitum energy intake of the participants during @number@ days.
During pilot testing , most residents consumed more food on average during treatment weeks in comparison with observation weeks.
During preschool and school , children experience a negative perception of school toilets.
During prospective follow up , all hospitalization events were recorded.
During puberty , the vulva and vagina mature under the influence of adrenal and gonadal steroid hormones.
During quantitative assessments , overall improvement in skin laxity was noted in @percent@ of evaluated patients.
During \ "Redirection , \ " retirees develop a \ "new self. \ "
During remembering , older adults ' vividness ratings were more related , relative to young adults' , to category representations in prefrontal cortex.
During replication , telomeres lose some of their genetic material but are repaired by the ribonucleoprotein telomerase.
During replicative aging of primary cells morphological transformations occur , the expression pattern is altered and chromatin changes globally.
During reproductive aging as the ovaries lose most of their follicles , estrogen production declines.
During retrieval , subjects viewed repeated object-location pairings , displacements of @number@ @number@ @number@ or @number@ grid spaces , and maximal corner-to-opposite-corner displacements.
During retrieval , the images presented at encoding were randomly mixed with new ones and displayed at the center of the screen.
During revision surgery , a power oscillating saw is used to remove bone cement while preparing the boney bed.
During RNA sequencing analysis of wild type and HGPS patient skin fibroblasts , we discovered two novel LMNA isoforms.
During running , peak HCF can be best predicted by hip adduction moment.
During sacral colpopexies , the surgeon must carefully dissect in the presacral space and avoid vital structures.
During self-selected gait , older adults walked with shorter step lengths and exhibited a lower required COF.
During sentence comprehension , older adults are less likely than younger adults to predict features of likely upcoming words.
During sham stimulation , task-related fMRI demonstrated that enhanced bilateral prefrontal activity in older adults was associated with reduced performance.
During skeletal development , osteoblasts produce large amounts of extracellular matrix proteins and must therefore increase their secretory machinery to handle the deposition.
During skin aging periostin expression decreases and contributes to the phenotype of aged skin.
During stimulation of the auditory cortex , younger children also showed a greater absolute increase in CBF than adults.
During storage , red blood cells ( RBCs ) undergo structural and functional changes that may reduce function and viability after transfusion.
During such times , and towards the end of life , emotional well-being may and eventually does decline.
During the 10-year follow-up period , @number@ of these subjects developed dementia.
During the 20th century , the average lifespan in the industrialized societies has enormously increased and it is still rising.
During the 2- to 3-year follow-up , participants recorded falls using a fall calendar.
During the 5-year follow-up , @percent@ of participants reported a deterioration in psychological distress.
During the 8th and 9th decennium the capillary area was reduced by a further @percent@ and @percent@.
During the 8-year follow-up period , @number@ died and @number@ survived.
During the 9-month follow-up period , there was a slight improvement of motor impairment , with no worsening of drug-related dyskinesia.
During the aging process , muscle mass is lost in specific body parts.
During the aging process , remodeling of several body systems occurs , and these changes can have a startling effect upon the immune system.
During the aging process , the immunoinflammatory response changes as a consequence of chronic antigenic stress.
During the catabolic process of autophagy , cytoplasmic material is transported to the lysosome for degradation and recycling.
During the chronic phase , patients with residual dissection are challenged by the competing risks of reoperation or death.
During the cohort study , men were contacted by telephone and assessed using an enhanced 2-stage cognitive screen.
During the course of ageing the decline of cognitive performance , including attention and working memory processes essential for arithmetic procedures is well known.
During the course of serious discussion , an unexpected interruption may induce forgetting of the original topic of a conversation.
During the course of their lifespan , erythrocytes actively shed phospholipid-bound microvesicles ( MVs ) .
During the dermatologic program , clinical and instrumental evaluations were made at the beginning of the study and at @number@ @number@ and @number@ months.
During the developmental process , @percent@ of thymocytes die by apoptosis.
During the development of the nervous system intra-axonal protein synthesis is crucial for the establishment of neuronal connections.
During the DNA damage response ( DDR ) , ubiquitination plays an important role in the recruitment and regulation of repair proteins.
During the elderly period , this organisation was largely lost.
During the emergent ZPDs , we observe how languaging brings together the cognitive and affective components essential for the participant's continued development.
During the experiment , @number@ participants ( ages 18-65 ) were asked to complete five saliva swallows in a neutral head position.
During the exponential growth phase , all cultures showed a similar pattern of growth and low beta-galactosidase activity.
During the fifth and sixth decades of life , the production of MLT diminishes , concurrently with an increase in the incidence of breast cancer.
During the final day of the DCE , deliberants voted on governance and oversight recommendations using an audience response system.
During the first evaluation , they reported falls , replied to a questionnaire of symptoms related to balance and had a sensory evaluation.
During the first @number@ years of the program's operation , @number@ of @number@ requested telemedicine visits were completed successfully.
During the first session , partners met each other and formed a relationship.
During the first year of sample collection , heifers had significantly lower STEC prevalence than cows ( @percent@ vs. @percent@ ) .
During the fMRI sessions , behavioural performance on the Eriksen flanker task and task-evoked neural activity were assessed.
During the follow-up , a higher percentage of PA patients developed type @number@ diabetes.
During the follow-up , @number@ ( @percent@ ) participants died , and @number@ ( @percent@ ) were institutionalized.
During the follow-up , @number@ subjects experienced vascular dementia and @number@ developed Alzheimer disease.
During the follow-up period between @date@ and @date@ , we identified @number@ cataract cases ( @number@ for women and @number@ for men ) .
During the follow-up period , in @number@ elderly ( 19 / 38 ) , one or more falls were recorded.
During the follow-up period , @number@ deaths occurred.
During the follow-up period ( @number@ ± @number@ years ) , @number@ participants ( @percent@ ) died.
During the follow-up period , we obtained information about stroke events that occurred in each subject.
During the follow-up , their life satisfaction was repeatedly measured using a four-item scale.
During the initiation phase , patients with type @number@ diabetes were randomized to LM75 / 25 or GL.
During the last century aging has been associated with decline and decay , but gradually more people lived ably and healthily in older ages.
During the last decade , evidence has been accumulating supporting the hypothesis that aging is genetically programmed and , therefore , precisely timed.
During the last decades , melatonin has been widely identified and qualified in various foods from fungi to animals and plants.
During the last decades survival has significantly improved and centenarians are becoming a fast-growing group of the population.
During the last decade , substantial progress has been made in understanding cellular and molecular mechanisms of photoaging.
During the last decade , the challenges of an ageing society became focus for extensive scientific , public and political discussions.
During the last decade , transcription factors and microRNAs have become powerful reprogramming factors for modulating cell fates.
During the last few decades , less invasive endovascular procedures such as percutaneous transluminal renal artery angioplasty with stent placement have become available.
During the last forty years , skin resurfacing has changed dramatically.
During the last month before death , @percent@ received chemotherapy ( including @percent@ during the last @number@ weeks ) .
During the last @number@ years , such an antioxidant , namely SkQ1 , was synthesized and studied in detail in our group.
During the last @number@ years , the median survival time and 5-year survival rate of esophageal cancer have improved significantly.
During the last years , numerous epidemiological studies have demonstrated a direct relationship between vascular calcification and low bone mineral density.
During the mean follow-up time of @number@ years , @number@ participants died ( @number@ with ChD ) , and only @number@ were lost to follow-up.
During the median @number@.8-year follow-up period , @number@ participants completed quarterly screening questionnaires.
During the median @number@ years of follow-up , @number@ deaths and @number@ CVD outcomes occurred.
During the median @number@ years of follow-up , @number@ incident HF events occurred.
During the middle years of life , sleep becomes more fragile and its sensitivity to psychostimulants may increase.
During the MT-phase , antagonist muscle co-activation was similar for both groups.
During the next two decades , the number of American baby boomers , who turn @number@ will increase by @percent@.
During the @number@ min reading task , the subject's closest comfortable eye-to-text distance and pupil size was monitored.
During the @number@ years in which The Gerontologist has been publishing , the politics of aging in the United States has undergone distinct changes.
During the @number@ years since introduction , the Swedish indicators have several applications.
During the onset of OA , articular cartilage and subchondral bone act in concert as a functional unit.
During the past decade , entrepreneurship in the healthcare sector has become increasingly important.
During the past decades , several agents have been approved that enhance cognition of AD patients.
During the past decade , there has been a sharp increase in the number of vascular procedures performed in the United States.
During the past few years , nonablative skin rejuvenation with infrared lasers has become ever more popular.
During the past four decades , many clinical trials investigating the effect of calcitriol on bone loss have been performed.
During the peptides activity mechanism investigation it was shown that short peptides regulate gene expression and protein synthesis.
During the period of stress accumulation , the transition from physiological hypertrophy to pathological hypertrophy results in the promotion of heart failure.
During the previous year @percent@ of men and @percent@ of women lacked continuous health insurance.
During the process of assessment many underlying behavioural , emotional and social problems became manifest.
During the project's lifespan , @number@ patients were considered for inclusion and @number@ participated.
During the recent decade , research around telomere biology has rapidly expanded due to its dynamic involvement in aging and longevity.
During the recognition test , participants were asked to determine whether action statements were or were not performed during the first session.
During the reproductive years , there is a gradual decrease in the severity of the cardinal features of PCOS.
During the reproductive years , the vagina responds to ovarian steroid hormone cycling , and both tissues adapt to the needs of pregnancy and delivery.
During the saccade to the target word , the preview word changed to the target word.
During the second session , participants imagined action statements from the first session , as well as new action statements.
During the second year , patients received @number@ mg of testosterone undecanoate every 2-3 months.
During these @number@ years of follow-up , @number@ participants developed IHD and @number@ developed MI.
During these procedures , direct visualization of the surgical field is replaced by image guidance for intraprocedural decision making.
During the study , each participant was presented with @number@ predetermined engagement stimuli in random order over a period of @number@ weeks.
During the study period , @number@ LTCF-acquired infections occurred , and the incidence was estimated to be @number@ episodes per @number@ resident-days.
During the study period , @number@ units of fresh-frozen plasma were issued.
During the study period , @percent@ of participants died.
During the study the lipid profile remained unchanged , thus the beneficial effects obtained were attributed to the pleiotropic effects of fluvastatin.
During the surgeries , we observed an excessively liquefied vitreous and a posterior hyaloid membrane that was tightly attached to the retina.
During the swing phase , the AT practitioners had significantly increased hip and knee flexion and a trend toward significantly increased dorsiflexion.
During the tests , the elbow angle and electromyographic ( EMG ) signals of the biceps brachii and triceps brachii were recorded simultaneously.
During the third phase corresponding to ages > 55 y , values decrease again with time.
During the weaning process and throughout childhood human offspring are supported by the provision of energy dense and easily digestible foods.
During the yearlong intervention , HRT suppressed the aging-associated upregulation of OGT mRNA that occurred in the controls.
During this 12-week prospective , open-label , single arm exploratory study , @number@ apparently healthy individuals were enrolled to receive YMLI.
During this controlled , but nevertheless artificial , ex vivo ageing , red blood cells accumulate lesions that can be reversible or irreversible upon transfusion.
During this past decade , the vascular endothelial growth factor ( VEGF ) pathway has been extensively studied.
During this period , @number@ hospital admissions in total were recorded , of which @percent@ were for male , and @percent@ were for female.
During this period , participation increased in women and men.
During this pilot study the occupants of over @number@ dwellings were interviewed by @number@ building services contractors using the dwelling check.
During this process , some women experience physical changes that may impact upon their psychological and social status , also affecting their quality of life.
During this time , developmental changes in interpreting and responding to social signals such as facial expressions also occur.
During this time the gap between period and cohort life expectancies has increased from @number@ to @number@ years.
During tongue-hold swallows , UES relaxation pressure was increased in the elders , whereas the younger group displayed a trend toward reduced relaxation pressure.
During treatment , the changes from baseline in total IPSS and IPSS sub-scores were significantly decreased at @number@ weeks and were maintained for @number@ weeks.
During usual daily activities , an appropriate protection against solar UV exposure should prevent clinical , cellular and molecular changes potentially leading to photoaging.
During voluntary contractions , motor neurone activity is modulated by descending input and sensory feedback.
Dutch costs , utilities and specific data on coagulation monitoring levels were incorporated in the model.
DVA could be an important adjunct to the current evaluation system of functional vision , thereby meriting additional attention in clinical assessment.
DVA evaluates accuracy of visual acuity during fixed velocity head movements.
DVA was then assessed.
DWI-based thermometry demonstrates that ventricular temperature declines with the normal aging process.
DWMRI was performed in @number@ ALS patients and @number@ age and sex-matched healthy controls.
DWP450 and OBoNT were comparable in efficacy and safety in the treatment of glabellar lines.
DXA / aBMD and QCT / FEA estimates were compared for their sensitivity to sex and age with multivariate statistical analyses.
DXA and HR-pQCT were used to assess BMD and bone structure.
DXA was used to estimate abdominal fat mass ( AFM ) by placing the region of interest over the L1-L4 region of the spine.
Dyadic analysis of older adults-adult children interviews was followed.
Dye penetration was scored using @number@ to @number@ criteria.
Dynamic aortic root diameters were measured and normalized to body surface area.
Dynamic balance showed similar changes ( p < @number@ ) .
Dynamic balance was assessed as anterior-posterior center of pressure ( COP ) displacement in response to sudden perturbations.
Dynamic balance was measured during Slow ( @number@ cm / s ) and Fast ( @number@ cm / s ) anterior and posterior perturbations.
Dynamic causal modeling demonstrated that their effective connectivity remained stable.
Dynamic changes were observed , notably a shift to increasing PC incidence in rural areas.
Dynamic contrast enhanced MRI data was extracted pixel-by-pixel and classified into @number@ patterns to indicate the perfusion function.
Dynamic contrast-enhanced MRI ( DCE-MRI ) is a method for studying BBB disruption in vivo.
Dynamic factors , such as increasing wealth or turning @number@ are associated with higher likelihood of LTCI purchase.
Dynamic imbalance caused by external perturbations to gait can successfully be counteracted by adequate recovery responses.
Dynamic isokinetic muscle fatigue testing may reveal increased vulnerability to disability and mortality beyond strength testing.
Dynamic postural stability and movement variability was quantified via whole-body center of mass motion.
Dynamic rhytides demonstrated greatest improvement , notably in the forehead ( @percent@ reduction ) .
Dynamics of more than @percent@ in lean mass were not associated with mortality.
Dynamics of regulatory factors can be modeled using Boolean networks ( BNs ) , among others.
Dynamics of symptoms and indicators in each group were evaluated in comparison with their data at the beginning and end of the study.
Dynamics of these parameters and overall effect of correction were shown to correlate with the severity of skin changes before the treatment.
Dynamics of vergence were quantified via peak velocity.
Dynamic stability at foot-off was also degraded in elderly , with a consequent increased risk of ML imbalance and falling.
Dynamic transcription profiling of CMS-exposed pretransformed cells indicated a paracrine autoregulatory loop of SAS factors and a dominant role of CMS-induced MYC.
Dynamic visual acuity ( DVA ) testing is a sensitive assessment tool for detecting VOR impairments.
Dyrk1A itself promoted tau E10 inclusion , whereas 9G8 inhibited E10 inclusion , and these actions were variable depending on the cell types.
Dysbiosis of the gut bacteria communities can cause many chronic diseases , such as inflammatory bowel disease , obesity , cancer , and autism.
Dyscirculatory metabolic encephalopathy was revealed to be the main pathology with the etiological mechanism based on dyscirculatorhypoxic and metabolic disorders.
Dysexecutive syndrome is considered as a key to the neuropsychology of geriatric depression , correlated with functional impairment in late life.
Dysfunctional autophagy may be an underlying mechanism causing elevations in ceramide that may contribute to pathogenesis in diseases.
Dysfunctional coping was associated positively with suicide ideation , but results did not support the hypothesized negative relationship with reasons for living.
Dysfunctional mitochondria generating less ATP have been observed in various aged organs.
Dysfunctional MQC , oxidative stress and inflammation are hallmarks of senescence and chronic degenerative diseases.
Dysfunctional telomeres can lead to either cancer or ageing pathologies depending on the integrity of the DDR.
Dysfunction in fast-spiking , PV + interneurons might set a low threshold for impairment of fast network oscillations and thus higher brain functions.
Dysfunction in mitochondria is a central theme in aging and diseases.
Dysfunction in nucleocytoplasmic transport is also an emerging theme in physiological aging and other related neurodegenerative diseases , such as Huntington's and Alzheimer's diseases.
Dysfunction of homologous recombination is a common denominator of changes associated with breast cancer-predisposing mutations.
Dysfunction of mitochondria has been associated with ageing and age-related diseases indicating their importance in the maintenance of cell homeostasis.
Dysfunction of the BBB occurs in a number of CNS diseases , including Alzheimer's disease ( AD ) .
Dysfunction of the immune system with advancing age is of crucial importance to the development of disability in later life and finally death.
Dysfunction of the intestinal barrier plays a key role in the pathogenesis of inflammatory bowel disease ( IBD ) and multiple organ failure.
Dysfunction or death of podocytes impacts glomerular permeability and filtration.
Dysfunctions in fibroblasts that occur with aging and the senescent process lead to the delayed healing observed in elderly people.
Dysfunctions in GH / IGF-I axis in most of ND are therefore reviewed.
Dysglycemia has been coined to define the prediabetic state.
Dyslipidemia can be associated with either positive or negative remodeling.
Dyslipidemia , hypertension and antihypertensive treatment were associated with an increased risk of falls.
Dyslipidemia , hypertension and DM did not influence the findings.
Dyslipidemia is a primary driver for chronic cardiovascular conditions and there is no comprehensive literature about its management in South Africa.
Dyspareunia improved or was cured ( score ≤1 ) by week @number@ in @percent@ of patients.
Dyspareunia-pain during sexual intercourse-is among the most frequent.
Dysphagia and asymmetric weakness are often found.
Dysphagia and malnutrition go hand in hand and lead to progressive worsening of mobility , immunity and quality of life.
Dysphagia in elderly patients has a major effect on nutrition and quality of life ( QOL ) .
Dysphagia is a common clinical problem whose prevalence is increasing with the aging population in the United States.
Dysphagia is a common problem among elderly people that limits some IADL domains.
Dysphagia is becoming a critical medical and social issue with aging population.
Dysphagia is commonly associated with the outcomes of neurodegenerative diseases such as SCA6.
Dysphagia may be further classified as oropharyngeal or substernal , depending on the location of this sensation.
Dysphagia was assessed using the Standardized Swallowing Assessment.
Dyspnea and abdominal pain were the most frequent non-trauma presenting complaints among geriatric patients and represented the main causes for admission.
Dyspnea is a subjective experience of breathing discomfort that can limit the ability and motivation to perform exercise or exertion.
Dysport was approved in Europe for the treatment of specific dystonias in @date@ and now has marketing authorizations in @number@ countries.
Dysproteostasis , unfolded protein response , endoplasmic reticulum stress and apoptosis perturb the Golgi secretory pathway in the smpd3- / - mouse.
Dysregulated anabolic responses to nutrition / exercise may contribute to sarcopenia ; however , these characteristics are poorly defined in female populations.
Dysregulated microRNAs ( miRNAs ; post-transcriptional regulators ) in adipose tissue may present an important link.
Dysregulated Wnt signalling is associated with human infertility and testicular cancer.
Dysregulation has been linked to the development of various human diseases , including neurodegeneration and tumorigenesis , infection , and aging.
Dysregulation in the circadian system induced by variants of clock genes has been associated with type @number@ diabetes.
Dysregulation of adipose tissue-derived bioactive molecules , termed adipokines , is recognized as common ground for insulin resistance and metabolic syndrome associated with obesity.
Dysregulation of BACE1 levels leading to excess Aβ deposition is implicated in sporadic AD.
Dysregulation of BDNF signaling is involved in several neurodegenerative disorders , including Alzheimer's disease.
Dysregulation of both systems has been implicated in aging and age-associated pathologies.
Dysregulation of circadian rhythmicity is identified as a key factor in disease pathogenesis.
Dysregulation of circadian rhythms is associated with neurodegenerative diseases and accelerated aging.
Dysregulation of metabolism , as a result of ethanol exposure , in the intestine leads to colon carcinogenesis.
Dysregulation of these pathways can contribute to chemotherapeutic drug resistance , proliferation of cancer initiating cells ( CICs ) and premature aging.
Dysregulation of this redox-signaling pathway may contribute to neurodevelopmental disabilities such as autism spectrum disorder ( ASD ) .
Dysregulation or loss of orexin signaling has been linked to narcolepsy , obesity , and age-related disorders.
D-β-Asp-containing proteins are produced in organs as they are affected by the aging process.
E200K is the most common mutation worldwide , is associated with gJCD , and was the most common in the UCSF cohort.
E2 also suppressed ACTH ApEn ( process randomness ) during continuous cortisol feedback ( P = @number@ ) .
E2 and estrone obtained from ovarian venous samples gradually decreased with age in postmenopausal women.
E2 carriers , however , demonstrated less efficient visual search performance on the dynamic scaling task.
E2 did not affect the AAO of AD.
E2F1 also induces Lsh protein expression and transactivates the Lsh promoter in 2BS cells.
E2F1 and FOXO3 are two transcription factors that have been shown to participate in cellular senescence.
E2F1 attenuates FOXO3-mediated expression of MnSOD and Catalase without affecting FOXO3 protein stability , subcellular localization , or phosphorylation by Akt.
E2F1 is the transcription factor most closely associated with genes down-regulated by ageing and is down-regulated at the protein level in osteocytes.
E2F1 physically interacts with the Lsh promoter by binding to each of the two putative binding sites and transactivates the Lsh promoter.
E2 , follicle-stimulating hormone , and markers of OS including hydroperoxides , thiols , uric acid , total and residual antioxidant power , were assessed.
E2 protects the heart from ischemic injury in basic studies , but the picture is more involved in the whole organism and clinical studies.
E2 was not associated with development of MetS ( OR = @number@ P = @number@ ) .
E2 was not associated with either all-cause or IHD mortality.
E2 was positively associated with inferior lead JPA ( β = @number@ p < 0.03 ) in men but not in women.
E3 ubiquitin ligases are crucial components in this defense mechanism.
E7 is the major oncoprotein of high-risk human papillomaviruses ( HPV ) which causes cervical cancer.
Each 10-mmHg higher SBP and DBP was associated with a @number@.26- and @number@.55-point higher MMSE score , respectively.
Each 10-point decrement in life-space ( OR = @number@ @percent@ CI = @number@.0-1.3 ) was associated with a higher risk of falls.
Each 1-day increase in storage was associated with a @percent@ increase in risk of new renal complications.
Each 30-min session included a group of three patients.
Each additional break · hr ( @number@ ) was associated with @number@ point increase in LEF.
Each additional chronic illness present at age @number@ reduced working life by a year , and each present at age @number@ by @number@ years.
Each age group for each data set consisted of @number@ HIV-1-infected and @number@ age-matched HIV-1-uninfected samples for a total of @number@ samples.
Each aMTS6 level was expressed as [ aMTS6 ] ( in ng ) / [ mg ] creatinine.
Each approach was associated with follow-up QoL when their scores were analysed continuously.
Each article also includes an informational tear sheet-Information for Family Caregivers-that contains links to instructional videos.
Each association remained significant after adjusting for the other slowing symptom.
Each available HbA1c method has advantages and challenges , such as its susceptibility to interferences.
Each biomarker was associated with at least one other resilience resource , suggesting that our choice of biomarkers was appropriate.
Each blinded reviewer correctly categorized photographs as either being \ "baseline \ " or \ "post-procedure \ " @percent@ of the time.
Each capsule of probiotics contained at least @number@ × 10 ( @number@ ) L. delbrueckii subsp. bulgaricus @number@
Each category had different characteristics of demographic information.
Each characteristic's association with restricted life-space was estimated uisng logistic regression.
Each child's intake of nutrients was estimated using the 24-hour dietary recall and food frequency questionnaire data.
Each child's lexical and grammatical output was assessed at @number@ months of age through parental report.
Each child stood for around 90s on two AccuSway force platforms ( AMTI ) .
Each class of medication produces a different hemodynamic effect.
Each clone is the progeny of a single B cell responding to Ag , with diversified Ig receptors.
Each cohort , as it goes through adulthood , follows in aggregate a path left by older ones , reshaping that path as it goes.
Each cohort showed later sleep onset ( weekend and weekday ) , later weekend sleep offset , and later DLMO with age.
Each community pharmacy team was provided training in relation to alarm symptoms to ensure there was consistency in reporting.
Each compared patients with celiac disease and confirmed pneumococcal infection to a specific reference group : inpatients and / or the general population.
Each completed four questionnaires to examine their mental and physical health status and anxiety levels related to falling.
Each complexin appeared to be dysregulated at a different Braak stage.
Each component of the BASMI was assessed , with the total score computed using the 10-point scoring system.
Each computed tomographic scan underwent three-dimensional reconstruction with volume rendering.
Each condition will consist of weekly 2-hour group-based classes over the course of the 6-week intervention.
Each copy of the minor rs12459419T allele decreases prototypic full-length CD33 expression by ∼ @percent@ and decreases the AD odds ratio by ∼ @number@
Each covariate was evaluated for its association with a specific type of bleeding.
Each criterion had a designated cut-off point to identify the mice with the lowest performance.
Each DCE included discussion among deliberants facilitated by a trained staff and simultaneously-translated in LA.
Each degree of freedom is controlled by a single motor.
Each disabled adult or older person was interviewed three times between @number@ and @number@ using a semi-structured topic guide.
Each discussion lasted for about @number@ minutes and was tape-recorded for verbatim transcription.
Each disease presents with characteristic cortical lesions and distributions of abnormal inclusions.
Each display contained one item that was larger than the others ( i.e. , a size singleton ) but was not informative regarding target identity.
Each dosage of cadazolid resulted in a lower recurrence rate than with vancomycin ( @number@ to @percent@ versus @percent@ ) .
Each drew Archimedes spirals , which were rated by a senior neurologist specializing in movement disorders.
Each drink provided @number@.3 + / -41.8 Kcal of energy and @number@.8 + / -4.7g of protein.
Each encoding task was performed under four difficulty levels to establish different effort levels.
Each enrolled patient was treated with @number@ gm PAM intravenously as the loading dose.
Each evaluation included administration of @number@ motor tests and @number@ cognitive tests from which global measures of motor and cognitive function were derived.
Each facial region's semilandmarks were aligned into a common coordinate system via generalized Procrustes superimposition.
Each factor had at least two items that were equivalent across all three perspectives , which suggests at least partial measurement equivalence.
Each factor is examined as a function of increasing age along with its potential impact on percutaneous penetration.
Each fifth disease was detected in a hospital , while share of preventive examinations made @percent@ for men and @percent@ for women.
Each follow-up day was classified by past-year cumulative duration of lithium use ( @number@ 1-60 , 61-300 and 301-365 days ) .
Each formulation was applied to the randomly assigned side of the face.
Each gene displayed a distinct pattern of interaction with known aging pathways.
Each gene was thoroughly interrogated with tag single-nucleotide polymorphisms ( SNPs ) , and gene-based tests were used to enhance power.
Each girl had a series of cephalograms taken semi-annually from @number@ to @number@ years of age.
Each group consisted of @number@ subjects.
Each group consisted of @number@ subjects in one decade ( except @number@ subjects in the group of @number@ to @number@ years ) .
Each group contained @number@ younger ( @percent@ men ) and @number@ older adults ( @percent@ men ) .
Each group demonstrated improvement after auditory rehabilitation or training on short- and long-term memory tasks , level of depression and cognitive status scores.
Each group discussion lasted approximately @number@ min and was guided by semistructured and open-ended questions.
Each group displayed an expected shift in daytime sleep as more children matured out of their naps.
Each group of six addressed questions on the nature of their beliefs and values , and factors influencing these beliefs and values over time.
Each group underwent 1-hour-long training sessions , twice a week , for @number@ months.
Each has their place , but upstream primary prevention has the largest effect on reduction of later dementia occurrence and disability.
Each increment was cured for @number@ seconds.
Each indicator loaded significantly on its corresponding latent factor , and standardized factor loadings > @number@ supported the convergent validity of the Turkish APQ-S dimensions.
Each individual was also assigned a neurofibrillary tangle stage ( B1-B3 ) , relating to the likelihood of having Alzheimer's disease.
Each intervention included vibration of the active plate.
Each interview consisted of a concept elicitation and cognitive debriefing phase.
Each item from the initial search was reviewed independently by members of the project team.
Each item was pondered based on the quintiles of its distribution in the study population.
Each item was presented by one of two sources : an experimenter black- or white-gloved hand.
Each lipid species was analyzed using a logistic regression model.
Each main group was subdivided as with ( Subgroup B ) or without ( Subgroup A ) a bonding system.
Each major stage of the lifespan is discussed , from infancy ( where our knowledge of dreaming is speculative at best ) to later adulthood.
Each mammalian cell contains multiple copies of the mitochondrial genome ( mtDNA ) .
Each measure was included one at a time in the model , adjusted for duration of follow-up and age at death.
Each mediated multiple cognitive outcomes , especially measures of neurocognitive speed , executive functioning , and episodic memory.
Each metabolite reflects a distinct intracellular process.
Each met at least @percent@ of the STROBE criteria.
Each missing protein cargo results in localized loss-of-function that can be partially modeled by disrupting the corresponding gene , sometimes with surprising results.
Each model examined subtests in four cognitive domains : memory , attention / executive function , language , and visuospatial skills.
Each newspaper received stories tailored to that community.
Each nucleosomal unit in this polymer provides versatile capabilities and dynamic range.
Each nucleosome is a highly stable unit , being maintained by over @number@ direct protein-DNA interactions and several hundred water mediated ones.
Each @number@ increase in the FI was associated with a higher risk of death ( HR @number@ @percent@ CI @number@ @date@ ) .
Each of four speeded tasks produced intraindividual mean rate ( IM ) and intraindividual standard deviation ( ISD ) scores.
Each of @number@ problems in the checklist was checked by at least one of the respondents.
Each of the five components of the frailty phenotype was considered a dependent variable in the hierarchical logistic regression models.
Each of the four healthy lifestyle factors was inversely associated with all-cause mortality and increased survival time.
Each of the Japanese foods was provided to mice.
Each of them collects a related group of anthropometrical features and changes specifically upon aging.
Each of the metabolic syndrome components exerts a specific signature of white matter microstructural abnormalities.
Each of them has to adapt himself to others.
Each of these biological events depends on the up-regulation of the cell-cycle inhibitor p21.
Each of these components represents a range of elements that contribute to the picture of complexity in chronic care.
Each of these conditions , along with aging , is associated with increased fracture risk for distinct reasons.
Each of these deficits can coexist and interact , producing both independent and additive impacts on brain health.
Each of these detrimental system processes must be targeted by specific measures of geriatric primary prevention.
Each of these has the potential to be enhanced or caused by HIV / AIDS , antiretroviral therapy , or both.
Each of these issues is further complicated by the effects of ageing.
Each of these issues is reviewed in detail with a focus on adverse effects and current debates regarding best practice.
Each of these issues was individually investigated to establish their influence on detachment.
Each of these ligands is induced with T-cell activation allowing greater opportunity to have a regulatory role.
Each of these may interact with either predisposing traumas in early childhood or precipitating events later in life.
Each of these models was carefully tested with nested cross-validation.
Each of these @number@ AD biomarkers induces a connectome alteration that is maximal when they coexist.
Each of these pathways leads to a final common result of unbalancing the anabolic and catabolic environment of the extracellular matrix in favor of catabolism.
Each of these possibilities will be considered , and correlational and causal evidence will be reviewed.
Each of these products has to be stored according to its particular components.
Each of these variables was negatively associated with healthcare trust , and together these accounted for approximately @percent@ of racial differences in healthcare trust.
Each of the seven novel genes code for proteins associated with one or more molecular pathways known to be involved in ALS.
Each of the three computerized support system interventions reported produced a significant enhancement in both prescribing and dispensing practices.
Each of the three hysteresis models yielded a marked ( P < @number@ ) reduction in estimated model residual error compared with no hysteresis.
Each one received an assessment of NT-proBNP on serum.
Each one-year increase in age resulted in patients being @number@ times more likely to be compliant ( @percent@ CI : @number@ to @number@ ) .
Each or combination of these pathological changes may cause cognitive impairment and aging.
Each outcome was recorded through a maximum of @number@ months or death.
Each participant also completed one DLW measurement , with a subset having a repeat.
Each participant completed a maximal exercise test and a 20-min. bout of walking at a self-selected pace.
Each participant completed a scale assessing dimensions of flow in a particular activity selected by the participant.
Each participant completed a standard measure of purpose in life.
Each participant completed the Council on Nutrition appetite questionnaire ( CNAQ ) and a UFOV test.
Each participant demonstrated a different recovery method from falling.
Each participant experienced three perturbations under five different visual conditions designed to alter visual input and head / trunk coordination.
Each participant gave their consent to take part in the research.
Each participant had a mean of @number@ ± @number@ chronic diseases , with an average GFI score of @number@ ± @number@
Each participant had a physical activity test to respond and had to perform handgrip , a four meter walk and one leg balance.
Each participant performed a flanker task before and after the intervention.
Each participant performed @number@ STS with @number@ s rest between trials.
Each participant received trivalent inactivated influenza vaccine after @number@ weeks , and had blood draws prior to and @number@ and @number@ weeks after immunization.
Each participant's EEG had been recorded approximately every @number@ months under sleep conditions.
Each participant's primary care physician provided initial endorsement of the intervention , followed by monthly automated telephone messages tailored to the patient.
Each participant underwent a full psychometric examination with standardised neuroimaging and clinical chemistry investigations.
Each participant underwent a vaginal examination and screening for vaginitis.
Each participant was asked the meaning of @number@ pictograms and underwent an assessment of abstraction and logical abilities with WAIS-III test.
Each participant was assessed by means of the TCI.
Each participant was assessed on cognitive functioning and social adaptation , and was checked for the presence of psychopathological disorders.
Each participant wore a wrist actimeter that logged activity during the whole experiment.
Each part of the aortic root expanded and contracted proportionally and harmoniously during the cardiac cycle.
Each pathologic subtype showed few distinctive features.
Each patient had at least one oral antidiabetic prescription claim ( A10B ATC code ) .
Each patient had their supine and standing or sitting blood pressure measured.
Each patient must be approached individually based on the suspected cause.
Each patient received one session of intradermal injection of BoNT / A on the left periorbital area and three sessions of MFR on the right.
Each patient received three treatments at three- to four-week intervals.
Each patient received treatment with @number@ U of study medication.
Each patient's medical record was reviewed for @number@ months after the date of admission.
Each patient's skin thickness was measured with ultrasonography pretreatment , immediately after each session , and at six months posttreatment.
Each patient's subsequent treatment was followed in the medical record to determine whether PCCT recommendations were implemented.
Each patient underwent a complete clinical evaluation including a comprehensive battery of language tests.
Each patient underwent a wide neuropsychological standardized assessment.
Each patient underwent @number@ minutes of individualized speech therapy with either AtDCS or PtDCS during each treatment session.
Each patient underwent supine and upright blood pressure measurement , tilt testing ( TT ) and carotid sinus massage ( CSM ) .
Each patient underwent to two clinical assessments for PD , with a time-lag of @time@ ± @number@ months.
Each patient was also administered a Mini-Mental State Examination ( MMSE ) cognitive screening test ( range 0-30 ) .
Each patient was asked to recall the number and names of their presently prescribed drugs and their associated medical conditions.
Each patient was clinically evaluated by the Western Ontario and McMaster University Osteoarthritis Index ( WOMAC ) .
Each patient was followed for a period of @number@ years from the date of the first antiplatelet medication prescription associated with TIA diagnosis.
Each patient was independently reviewed by two pharmacist reviewers.
Each @percent@ increase in ECV was associated with a @percent@ increased risk of recurrent AF.
Each PET and SPECT image was normalized into Montreal Neurological Institute template aided from individual MRI for comparison.
Each phase involved brainstorming , voting , and consensus among participants.
Each point increase in log-based autotaxin corresponded to a @number@ to @number@ times higher likelihood of having MCI and AD , respectively.
Each point increase in the MedDietScore was associated with a significant @number@ % reduction of death risk.
Each process could alter axonal conduction velocity , but to what end ?
Each product had a labeled contraindication for at least one specific condition.
Each protein should be regarded as a unique entity that has evolved to be functional in the organism to which it belongs.
Each received three treatments to the full face with fractionated bipolar RF device ( Syneron Inc. , Irvine , USA ) spaced @number@ days apart.
Each risk-reduction scenario was associated with both annual and lifetime cost savings , which accounted for increased longevity associated with decreased risk profiles.
Each sample has been stretched to failure at a speed of @number@ mm / min and force vs. elongation was recorded.
Each sample was divided into @number@ portions : musculotendinous , tendinous , and tendon-bone junction.
Each sample was sequenced twice using the fluorescent dye termination method.
Each sample was transcribed , segmented into utterances , and coded for main clauses and all types of finite and non-finite subordinate clauses.
Each scale is a five-point photonumeric scale based on computer-simulated photographs incorporating each aspect to be evaluated in a stepwise manner.
Each scan was segmented using thresholding techniques.
Each SD greater CFPWV was associated with lower TCBV equivalent to @number@ years of brain aging.
Each session included intravaginal treatment followed by treatment of labia majora and the perineum.
Each set included @number@ weekdays and one weekend day.
Each set of @number@ ratings was reduced to the same single underlying factor , denoted dependability , a trait comparable to conscientiousness.
Each setting provides an important context for examining the methods of obtaining and integrating informed stakeholder voices into the policy-making process.
Each slide was presented on the left side of the participant once the first step was initiated.
Each soft trial was followed by 4-8 hard trials to generate a wash-out effect.
Each solution was left on the acid-etched dentin for @number@ min.
Each specimen's deciduous and permanent teeth were rated for mineralization stage.
Each specimen was constituted of one disc in colorless acrylic resin and another colored with a basic sclera pigment.
Each standard rule has been classified with a level of evidence.
Each stimulus consisted of two words arranged on top of a screen , which had to be attributed to a homonym at the bottom.
Each stimulus was compared with all others.
Each stimulus was repeated , allowing us to index dynamic stimulus-driven competition from places.
Each structure was broken into two parts , a high iron content region and a low iron content region.
Each study arm was synthesized and reported as providing sufficient or insufficient \ "evidence of age-related muscle anabolic resistance \ ".
Each study included separate analysis for patients with a diagnosis of dementia and / or neurological disease.
Each study wave was conducted for @number@ years ; in individuals , the entire follow-up period was @number@ years.
Each style has its own principal injuries , both acute and chronic , related to the individual technique.
Each subgroup was subjected to shear test before and after @number@ @number@ thermal cycles.
Each subject attended to a target item as the items in a 6×6 visual matrix flashed.
Each subject had @number@ scans , @number@ per day separated by 2-6 wk , including brain and torso or pelvis scans.
Each subject received a series of four treatment sessions on the right side of the face at two-week intervals.
Each subject received five treatment sessions during a period of @number@ days.
Each subject received four treatments at 10-day intervals.
Each subject received @number@ full-face treatments 4-6 weeks apart.
Each subject received @number@ sessions of stimulation over a one-month period.
Each subject served as his / her own control , comparing results before treatment , and @number@ months following treatment end.
Each subject summary was presented to the ESHRE Workshop Group , where omissions or disagreements were resolved by discussion.
Each subject underwent ambulatory blood pressure monitoring for 2h.
Each subject was assigned to one of four cue conditions : visual , verbal , multimodal ( visual-plus-verbal ) or no cue.
Each subject was injected with PP-501-B in @number@ NLF and Restylane Perlane in the other.
Each subject was observed between @number@ and @number@ times , resulting in @number@ annual intervals from a total of @number@ observations.
Each subject was required to observe and evaluate affective pictures while autonomic parameters were recorded.
Each subject was scanned on two or more visits , separated by at least @number@ year for a total of @number@ imaging sessions.
Each subject was treated twice with the SmartSkin device at three- to five-week intervals.
Each subject will have to compile a structured questionnaire at enrolment and after @number@ @number@ @number@ @number@ and @number@ months.
Each subsequent cycle of weight loss-restoration differed from the previous one and had a pronounced age-related character.
Each successful enrollment required an average of @number@ hours for recruitment and scheduling of the interviews.
Each task was performed with the REAplan , a distal effector robotic device that allows upper limb displacements in the horizontal plane.
Each test group consisted of @number@ participants.
Each test was performed with free and limited arm movement and the outcomes were compared.
Each test was presented via the telephone with and without processing.
Each time a cell divides , 25-200 base pairs are lost from the terminal sequence of chromosomes.
Each tissue specimen was subjected to DNA extraction , RNA extraction , and immunofluorescence.
Each tooth was sectioned in order to obtain @number@ sticks , which were submitted to microtensile bond strength test ( µTBS ) .
Each training program included recreational activities , six to eight resistance exercises for circuit training and chair-based exercise for the lower extremities.
Each treatment was assessed for its effects on subjects ' appearance , lesion count reductions , and tolerability.
Each trial consisted of a 30-s constant-torque stretch of the plantar flexor muscles.
Each trial was segmented into basic tasks ( sit-to-stand , walk , turn ) .
Each type of nanodelivery system offers distinct benefits depending on the compatibility of nanoparticle properties with the properties of the bioactive and the desired application.
Each type shows inclusions in their perikarya , and in the case of astrocytes and microglial cells some of these inclusions are phagocytosed myelin.
Each unit increase in BMI at early adulthood was associated with a @number@.89-month decrease in age at HCC diagnosis ( P < @number@ ) .
Each unit increase in the Mediterranean dietary score ( MedDietScore ) was associated with a @percent@ decrease in the odds for dementia.
Each variant showed a distinct spatiotemporal pattern of altered functional connectivity compared to age-matched controls.
Each vertebra was photographed in standardized positions and measured using ImageJ software.
Each was asked to first indicate their preference for pharmacological , psychological , or combined treatment.
Each WG was tasked with synthesizing a summary of the evidence for each of these topics and delineating the remaining gaps in our knowledge.
Each woman was randomly matched to a referent woman born in the same year ( ±1 year ) who had not undergone bilateral oophorectomy.
Each Yarning Circle was facilitated by an Aboriginal researcher who incorporated six indicative questions into each discussion.
Each year , @number@ million people worldwide survive the neurologic injury associated with a stroke.
( EAD-200 ) and Group D a quadruple therapy with esomeprazole , amoxicillin , DOX-200 mg b.i.d. , and bismuth subcitrate ( EADB-200 ) .
E , and EB-Vit.
Earlier-acquired words were recalled significantly better than later-acquired words and this was apparently due to both enhanced encoding and consolidation of earlier- over later-acquired words.
Earlier communication around disease implications , symptom burden and objectives of care feed into the integrated model for best and agreed outcomes to be achieved.
Earlier detection of cognitive impairment offers significant benefits , but remains difficult to do in practice.
Earlier disease onset in MD and BPD groups correlated with more pronounced BrainAGE , reaching effect sizes of the SZ group.
Earlier identification of AF with appropriate anticoagulation may decrease stroke morbidity and mortality.
Earlier pharmacological and POMC gene transfer studies demonstrate that melanocortin activation in either site alone improves insulin sensitivity and reduces obesity.
Earlier radiographic studies show rather few pathologic findings related to third molars.
Earlier reports have suggested associations between later age at puberty and schizophrenia in males.
Earlier reports of age-related changes in P3 are supported by the present results.
Earlier research tended to focus on pharmacological activities of RSV related to cardiovascular systems , inflammation , and carcinogenesis / cancer development.
Earlier student-teacher relationships predicted subsequent changes in child behavior problems and social skills.
Earlier studies have revealed age-dependent differences in perception by dynamic touch.
Earlier studies suggest that HIV viral load , CD4 + T-cell count , and antiretroviral therapy are associated with cardiovascular disease ( CVD ) risk.
Earlier studies with thrombelastography have demonstrated procoagulant activity in elderly patients with coronary artery disease.
Earlier treatment with renin–angiotensin system inhibitors may improve abnormal LA-LV interaction in this patient population.
Earlier , we proposed the derivative function of the Gompertz equation as a superior descriptor of senescence rate.
Earlier , we showed that the offspring from exceptionally long-lived families have a more favorable glucose metabolism when compared with controls.
Early achievement of clinical response and mucosal healing might associate long-term response.
Early active , late active , smoldering , inactive , and shadow plaques were distinguished.
Early adaptation was similar across groups , though HYA and HOA continued to adapt into late adaptation while PD did not.
Early adolescence is the period when gender-related metabolic changes occur.
Early adult cognitive test scores were available for @number@ men.
Early adulthood hypertension was not associated with dementia , though effect estimates were elevated among women.
Early adulthood PFD was not related to CRP.
Early adult women had a stronger positive resistance to adopt observer's perspective-body appreciation relationship than emerging and middle adult women.
Early adversity also has enduring effects on life evaluations , offsetting the influence of buoyant expectations.
Early Alzheimer's disease ( AD ) is associated with deficits in episodic memory.
Early and accurate clinical diagnosis is the first step in the proper initiation of treatment modalities and improvement in overall patient outcome.
Early and accurate diagnoses are very important for patients and their families as there are a number of diseases that can be treated.
Early and definitive diagnosis of Alzheimer's disease ( AD ) can lead to a better and more-targeted treatment and / or prevention for patients.
Early and late activated T-cells were also reduced by MSC therapy.
Early and late life events were assessed during a home interview.
Early- and late-stage osteoarthritis appear as separate profiles , notably in terms of treatment response.
Early angiogenesis includes formation of an excessive primitive network that needs to be reorganized into a secondary vascular network with higher hierarchical structure.
Early ANM is associated with early preceding fertility loss , whereas late menopause is associated with reduced morbidity and mortality later in life.
Early ART could better improve CD4T-cell function.
Early AR was defined as < @number@ years ( boys ) and < @number@ years ( girls ) .
Early assistance from the ICT was important for prevention of worsening of methicillin-resistant S aureus infection.
Early B-cell differentiation has not been defined in patients with early-onset atopic dermatitis ( AD ) .
Early bilingual exposure imparts fundamental changes to classic language areas instead of alterations to brain regions governing higher cognitive executive functions.
Early blindness results in both structural and functional changes of the brain.
Early bronchial hyperresponsiveness , before any evidence of airway inflammation , is associated with adverse respiratory outcomes.
Early complications ( less than @number@ month after the intervention ) occurred in @number@ patients ( @percent@ ) .There were no post-operative deaths.
Early complications , occurring within days of the procedure , can be divided into non-hypersensitivity and hypersensitivity reactions.
Early complications were edema and ecchymosis.
Early detection allows for timely implementation of targeted interventions to improve gait and / or cognition.
Early detection and access to the history of a fall is crucial for efficient care and secondary prevention in cognitively impaired individuals.
Early detection is essential for maximum benefit.
Early detection may help slow the progression of the disease.
Early detection might lead to earlier intervention.
Early detection of Alzheimer's disease ( AD ) is important since treatments are more efficacious when used at the beginning of the disease.
Early detection of gait and cognitive impairments would provide a better understanding of disease pathophysiology and progression.
Early detection of gait disorders and fall risk permits early intervention and , in the best-case scenario , fall prevention.
Early detection of late onset hypogonadism is recommended as testosterone substitution improves quality of life.
Early detection of malnutrition is an important task in clinical practice.
Early detection of metabolic syndrome in this population may be useful to prevent cardiovascular diseases.
Early detection of skin cancers and treatment of precanceroses is of utmost interest of health providers.
Early detection of vascular disease in cocaine addiction by multimodality imaging is discussed.
Early detection permits timely implementation of targeted interventions to improve gait and brain function.
Early diagnoses as well as prompt and effective treatment are essential for avoiding severe outcomes.
Early diagnosis and appropriate treatment will avoid unnecessary tooth extraction and result in a better prognosis.
Early diagnosis and early treatment are therefore necessary in such patients.
Early diagnosis and treatment can prevent further bone loss and fractures.
Early diagnosis and urgent aggressive treatment are important for aging patients.
Early diagnosis is appropriate and important for developmental disorders such as autism spectrum disorder.
Early diagnosis is the key to successfully treating many diseases.
Early diagnosis of cancer affords early intervention and greatest chance of cure.
Early diagnosis of glaucoma remains difficult.
Early diagnosis of pseudoaneurysm is very important , because this complication can induce disabilities such as upper extremities and finger loss.
Early diastolic mitral annular velocity ( E' ) and E / E ' ratios were measured with tissue Doppler imaging of lateral mitral annulus.
Early discoveries support a paradigm in which lncRNAs regulate transcription networks via chromatin modulation , but new functions are steadily emerging.
Early during the course of infection natural killer T-cells ( NKT-cells ) are major contributors to the elevated IL-17 response in aged mice.
Early efforts have established the fundamental role of HIF in VHL-defective tumorigenesis and in particular renal cell carcinoma.
Early engagement into a person-centered individualized intervention arrests or reduces the rate of FD over the next @number@ months.
Early epidemiological studies of hyperplastic polyps were performed without knowledge of the serrated pathway and likely included a mixture of SPs.
Early epidemiologic studies have hinted at an anticancer role for multiple antioxidant compounds that are present in fresh produce.
Early evaluation of cognitive functioning is essential to establish adequate preventive and intervention strategies.
Early evaluation of correctable possibilities , including imaging studies , may be key to management.
Early evidence indicates detectable clonal mosaicism increases in frequency with age and could preferentially occur in males.
Early exposures to social disadvantage may increase the risk of late-life dementia.
Early findings are summarized , current evidence presented , and future directions projected.
Early focused intervention in frail geriatric patients is warranted to improve long-term outcomes.
Early follicular FSH , LH , Oestradiol ( E2 ) and AMH levels were measured.
Early growth measures were not associated with retinal venular caliber.
Early growth response @number@ ( Egr-1 ) is a transcription factor that is significantly up-regulated in AD brain.
Early ideas about the capacity to sing were provided by well-known neurologists , such as John Hughlings Jackson and Adolf Kussmaul.
Early identification and care planning for individuals with delirium at PAC admission may be essential to improve outcomes.
Early identification and treatment of post-stroke depression may significantly reduce suicide risk in stroke patients.
Early identification of changes in behavior is essential for the adequate treatment and management of medical and behavioral problems , and for monitoring outcomes.
Early identification of cognitive function and to prevent delirium are needed to improve functional status following orthopaedic surgery.
Early identification of patients at risk for LV remodeling may have important prognostic and therapeutic implications.
Early identification of those at higher risk of dementia may play a part in secondary prevention and has received great clinical and research interest.
Early increases in serotonin levels potentially explain reductions in anxiety behaviors and sleep.
Early infancy , a phase of very rapid growth , constitutes a critical period for the onset of overweight.
Early intervention and support programmes can significantly reduce the negative effects of HI.
Early in the atherosclerotic disease process , estrogen exerts protective effects on the endothelium and retards plaque formation.
Early in the last century , it was commonplace for elderly women to live with their adult children.
Early language development sets the stage for a lifetime of competence in language and literacy.
Early life adversity was related to an increasing risk of declines in physical and mental health.
Early life development and experience appears to provide a distal basis upon which additional risk and protective factors interact in the development of dementia.
Early life exposures influence numerous social determinants of health , as distal causes or confounders of later health outcomes.
Early-life or long-term , accumulated lead exposures may be etiologically more relevant to accelerated cognitive decline at older age.
Early life physical development can be captured using adult measures of height and head circumference.
Early life stress ( ELS ) poses a risk for mental disorders and aging-related diseases.
Early-life wheezing-associated respiratory tract infection by rhinovirus ( RV ) is considered a risk factor for asthma development.
Early loss of inferior temporal RNFL in ADOA is related to superotemporal central scotoma.
Early measurement of whole blood viscosity may be helpful to assess the risk of stroke.
Early microvasculature adaptations might be part of the underlying mechanisms for these associations.
Early mobilization reduces the impact of immobility and improves outcomes for older patients.
Early mobilization was possible in @percent@.
Early mortality rates were consistent with previous reports.
Early motherhood is paralleled by poorer physical health in West Germany , whereas late motherhood is associated with lower psychological well-being in Eastern Germany.
Early NC and delayed NC were defined as NCs performed before and @number@ days after the day of AKI diagnosis , respectively.
\ "Early \ " NP and \ "late \ " NP correlated significantly with objectively early and later cognitive performance , respectively.
Early numerical abilities provide the foundation for future academic and professional success in an increasingly technological society.
Early-onset Alzheimer disease in this family was associated with a V717G mutation in the amyloid precursor protein gene ( APP ) .
Early-onset Alzheimer's disease ( EOAD ) has distinct clinical characteristics in comparison to late-onset Alzheimer's disease ( LOAD ) .
Early-onset cognitive impairment diagnosis is often challenging due to the overlapping symptoms between the different degenerative and non-degenerative conditions.
Early-onset correlated with the need for more information about diagnosis and prognosis.
Early-onset disability correlated with joint deformities , pain and anxiety.
Early-onset familial forms of the disease ( FAD ) are caused by inheritance of mutant genes encoding presenilin @number@ ( PS1 ) variants.
Early-onset seizures represented @percent@.
Early postoperative lower extremity muscular endurance rehabilitation must be provided.
Early prevention and intervention approaches may be needed in high-risk groups ; longitudinal studies would inform these approaches.
Early prevention with a goal of all risk factors at optimal levels should become the priority of CVD prevention in the future.
Early prevention with antioxidants is mandatory.
Early recognition and aggressive treatment is vital to improving the prognosis of hyperglycemic emergencies and severe hypoglycemic episodes.
Early recognition of cognitive decline could promote timely implementation of preventive strategies.
Early recognition of comorbidities such as dementia and delirium as well as speedy and competent therapeutic treatment can limit consequences and impact.
Early recognition of nephrotoxicity is critical , as are preventative steps when applicable.
Early school leavers performed worse on both measures.
Early significant research on the topic of old lesbians is noted and suggestions for future research studies are recommended.
Early signs were attributed to aging or personality.
Early stages of oral diseases such as caries and periodontal disease are vigorous , preventable , and reversible.
Early studies have indicated that the SUMO system is likely altered with AD-type pathology , which may impact Aβ levels and tau aggregation.
Early subjective functional results ( maximal flow rate , IPSS , and post-void residual urine ) appeared the same as those obtained following laser prostatectomy.
Early supernormality measurements benefit most from within subject comparisons.
Early thinking about music processing can be linked to the start of Gestalt psychology.
Early timing of progestin-only contraceptive dispense following delivery ( ≤3 months ) was not significantly associated with persistent pelvic girdle pain.
Early- to midlife musical training may be associated with improved late-life episodic and semantic memory as well as a useful marker of cognitive reserve.
Early uptake of [ ( @number@ ) C ] -Pittsburgh Compound B ( ePiB , 0-6 minutes ) estimates cerebral blood flow.
Early warning deterioration is a relevant issue in this setting.
Early work has discussed various methods of estimating age-specific incidence of dementia , among which the illness-death model is popular for modeling disease progression.
Earth is beset by escalating , manmade , environmental crises and our exploding population will eventually lack water , food and vital materials.
Ease of laryngeal mask airway placement was graded using a scale from @number@ to @number@
Easily isolated in relatively large quantities from contaminant-free cell cultures , plant metabolites target skin ageing mechanisms , above all redox imbalance.
East Asians had lower concentrations of androstanediol glucuronide and African Americans had higher concentrations of estrogens.
Eastern-European COPD strategies should focus on prevention , risk-factor awareness , and early detection.
Easy access to these data , and their computational analysis , is of great importance in order to pinpoint the causes and effects of ageing.
Easy and painless to collect , human urine is a source of noninvasive biomarkers.
Easy placement was noted in @percent@.
Eating habits may affect favorably or unfavorably on the process of aging and the functioning of various tissues , organs and the whole body.
EB demonstrated a greater but nonsignificant improvement in vertical momentum ( P = @number@ ) .
EBSHP relied on projection of localized prevalence estimates to the national population.
EBV infection might induce DNA damage in CNE1 cells , which causes genome instability and initiates or promotes the tumorigenesis and development of NPC.
E-cadherin ( CDH1 ) methylation status was determined by methylation-specific PCR ( MSP ) .
E-cadherin is the core protein of the epithelial adherens junction.
ECAS total score ranges from @number@ ( worst performance ) to @number@ ( best performance ) .
Eccentric exercise causes little cardiovascular stress ; thus , it may not generate the overload required to elicit cardiovascular adaptations.
Eccentric exercise has gained increasing attention as a suitable and promising intervention to delay or mitigate the known physical and physiological declines associated with aging.
Eccentric resistance exercise ( ERE ) is considered a nonpharmacological tool to prevent the chronic degenerative profile associated with aging and obesity.
Eccentric resistance exercise with its high-force producing potential , at a low energetic cost , may be ideally-suited to address muscle impairments in this population.
ECD and CCT correlated directly ( r = 0.232 , P < 0.01 ) .
EC families also showed better physical / pulmonary function than non-EC families ( β = @number@ SE = @number@ p = @number@ ) .
EC families showed a better a metabolic profile ( β = @number@ SE = @number@ p = @number@ ) than non-EC families.
ECFCs from GDM pregnancies were resistant to hyperglycemia-induced senescence compared with those from controls.
ECG abnormalities were more frequent in ChD patients ( @percent@ versus @percent@ , P < 0.001 ) .
ECG changes are not specific for MB and resting ECG is often normal or presents ST segment anomalies.
ECG indices for detection of LVH have insufficient predictive values in geriatric subjects and should therefore not be used clinically for this purpose.
ECGs were coded and classified as abnormal , according to the Minnesota code system.
Echinococcus granulosus ( E. granulosus ) is a diverse zoonotic parasite and causes Cystic echinococcosis ( CE ) disease in humans and livestock.
ECHO-AGE recommendations were completely or partially followed in @percent@ of residents.
Echocardiographic analyses revealed a left ventricular mass of @number@ g and left ventricular end-diastolic diameter of @number@ cm.
Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following Doppler acquisition and measurement protocols approved by the European Association of Cardiovascular Imaging.
Echocardiographic evaluations were performed @number@ day before and @number@ days after ASD closure.
Echocardiography , 6-min walk test , quality of life and endothelial function were also assessed.
Echocardiography provides a noninvasive assessment of cardiac structure and function.
Echocardiography revealed concentric left ventricular hypertrophy with enhanced echogenicity and preserved ejection fraction.
ECHO-CT may improve patient transitions to postacute care at lower overall cost.
Echography demonstrated that the peptide blend reduced subepidermal low-echogenic band thickness and improved its density.
Echotexture was evaluated and degenerative features classified as absent , mild , moderate and severe.
ECMO influences the pharmacokinetics of drugs.
ECM proteins become increasingly cross-linked with age , and this cross-linking is probably important in the decline of the ECM's function.
EC N1ICD expression in melanoma correlated with shorter progression-free survival.
ECOG-PS was @number@ or @number@ in @number@ patients and ≥2 in @number@ there was missing data for one patient.
Ecological concerns , a form of contributing to the public good , were positively related to age.
Economic and political trends underscore the importance of engaged scholarship as evidence that colleges and universities are serving their constituencies.
Economic and socio-demographic resources , environment , and function play a role in determining the older person's homebound status.
Economic disadvantage also entails a greater likelihood of living with kin.
Economic status of the respondents was determined on the basis of questions on how well they could manage their own budgets.
EC recruits volunteers aged @number@ and older into high-impact mentoring and tutoring roles in public elementary schools that are designed to also benefit the volunteers.
ECSC-predicted FEV1 , FVC and FEV1 / FVC were poorly matched to Malagasy measurements.
E , CSE-Querc , EB-Vit.
E , CSE-Vit.
ECs in the tumor microvessels were sporadically immunostained for VASH1 , although no VASH1 staining was observed in the non-neoplastic renal tissues.
Ectopia lentis and aortic dilatation were both similarly discriminating.
Ectopically expressed JunD specifically increased the expression of primary and mature forms of miR-29b , whereas JunD silencing inhibited miR-29b expression.
Ectopic E2F1 increases expression of Lsh at both transcriptional and translational levels.
Ectopic expression of COX-2 in hepatocytes constitutes a nonphysiological condition ideal for evaluating the role of prostaglandins ( PGs ) in liver pathogenesis.
Ectopic expression of human telomerase reverse transcriptase ( TERT ) in bovine embryos increased telomerase activity and in turn increased telomere length.
Ectopic expression of LINC00858 in NSCLC cells promoted cell proliferation and induced cell migration and invasion.
Ectopic expression of WIF1 in glioblastoma cell lines revealed a dose-dependent decrease of Wnt pathway activity.
Ectopic fat contributes to lipotoxicity and has been implicated in the development of a metabolic syndrome that increases risk of age-associated diseases.
Ectopic lipid accumulation is now known to be a mechanism that contributes to organ injury in the context of metabolic diseases.
ECV and FO increased with age in males.
ECV was also significantly associated with age in women after multivariable adjustments.
EC was measured at ages @number@ and @number@ using age-appropriate laboratory batteries as well as mother reports.
ECW / ICW index was significantly and positively correlated with age ( P < @number@ ) .
Eczema and infections was found to be most common diseases seen in elderly.
Ed.44 , 91-96 ] .
ED clinicians need easy tools for delirium detection.
Edden et al.
E degenerative changes were seen mainly in L periphery.
EDEM1 associates with lifespan in animal models , although not humans.
Edentulism was prevalent earlier for those with ID.
Edentulism without tooth replacement and having < 5 teeth resulted in an increased risk of substantially compromised OHRQoL.
Edentulousness without prosthesis was associated with malnutrition , oral symptoms and infrequent use of oral care services.
Edentulousness without prosthesis was associated with poor nutritional status , oral symptoms and infrequent use of dental services.
Edentulous patients were excluded.
ED incidence and remission were observed in @percent@ ( n = @number@ ) and @percent@ ( n = @number@ ) of eligible men , respectively.
Edoxaban has some peculiar pharmacological properties and outcome data.
ED progression was defined as worsening of ED over time , whereas regression was defined as a lessening of ED severity.
EDs in aging populations must anticipate the influx of vulnerable , elderly patients and have in place interventional programs to care for them.
( Eds. ) ( @number@ ) .
EDS performed worse than EHN on both item and order recognition using a temporal style of presentation.
EDS prevalence was @percent@ among men and @percent@ among women.
EDS was defined as a score > 10 on the Epworth Sleepiness Scale.
EDs with a geriatric nurse clinician , relatively fewer nursing resources , and longer ED stays improved more quickly.
Educated women with a good financial situation had a significantly higher HRQOL , compared to those with a lower education and in poor living conditions.
Educating intensive care unit nursing team members in early recognition of delirium and other fall risk factors can improve patient safety outcomes.
Education about growing older beginning in grade school was recommended.
Education affected terminal decline differently across the domains , but this modification was not consistent with the predictions of cognitive reserve theory.
Education affects depression through different underlying mechanisms , and the single most important pathway is through developing cognitive ability.
Educational attainment , a proxy for \ "cognitive reserve , \ " may help to explain this apparent contradiction.
Educational attainment is associated with many health outcomes , including longevity.
Educational attainment , poor marital quality , and spouses ' health and care needs do not predict work exits.
Educational attainment was categorized as less than high school education , high school graduate , some college , or college graduate.
Educational attainment was classified into four levels , while household income and grade of employment were measured as indicators of current socioeconomic circumstances.
Educational can alter these beliefs.
Educational differences in smoking-related health problems are expected to increase.
Educational experiences and employment characteristics reduced gender and racial / ethnic disparities , but family relationships exacerbated them.
Educational inequalities in life satisfaction were narrowest in Scandinavian and Bismarckian regimes among both genders.
Educational influence on cognitive performance has been extensively agreed in Neuropsychology.
Educational initiatives are needed to avoid unnecessary risks.
Educational interventions can increase knowledge and influence preventative activity to decrease the likelihood of further TBI.
Educational interventions may also be effective in reducing underprescribing.
Educational interventions targeting physicians may improve antimicrobial prescriptions.
Educational level and marital status had no significant effects on the likelihood of falls ( p > @number@ ) .
Educational level and marital status may contribute to hip fracture risk.
Educational programmes should be developed to inform clinicians about the magnitude of the polypharmacy phenomenon and the patient characteristics associated with polypharmacy.
Educational programs aimed at the maintenance of proper nutrition in the older adults may reduce malnutrition and the related diseases.
Educational programs are described for elderly patients and for the health care professionals who serve them.
Educational promotion of knowledge about aging is emphasized for the formation of positive attitudes toward older adults.
Educational quality ( percent white students ; urban / rural school ; combined grades in classroom ) was operationalized using canonical correlation analysis.
Education and BDI-II significantly predicted the intercept for attention / executive function and language abilities.
Education and cognitive leisure activities are major predictors featured in dementia studies.
Education and enhanced awareness of the effect of age on fertility are essential in counseling the patient who desires pregnancy.
Education and enhanced awareness of the effect of age on fertility are essential in counseling the patient who desires pregnancy.
Education and financial resources consistently proved to be key economic health assets for older adults.
Education and income have independent and unique contributions to dietary adherence.
Education and marital status also had an important impact on HRQOL.
Education and marital status were modestly associated with a small number of hormones.
Education and occupation act as proxies for CR and are associated with a lower risk of AD and delayed onset of symptoms.
Education and outreach to these groups needs to be tailored.
Education and permission from a health care professional may help to alter such misconceptions.
Education attainment was divided into two levels : high and low.
Education-based health promotion strategies for hypertension control might be more effective in elderly women than in elderly men.
Education can have a confounding effect on income or interact with it as a health determinant.
Education could play a role in the constitution of cerebral reserve capacity.
Education did not attenuate any of these associations.
Education directly affected grey matter volume in all the samples ( P = @number@ ) with lower education attainment being associated with lower volumes.
Education , employment status , and birth in São Paulo were not associated with use.
Education , family environment and earlier alcohol use behaviors and expectancies were reliable predictors of alcohol problem severity in young adulthood.
Education for nurses , social workers , administrators and others who comprise the comprehensive care system must be mandatory.
Education had the strongest direct association with cognition , followed by current material circumstances.
Education has been used as a proxy for CR.
Education interventions may help older adults with HIV learn to improve and protect brain health and cognition as they age.
Education interventions that stimulate complementary feeding practices can improve the nutritional status of children and may protect against future chronic diseases.
Education involves learning new information and acquiring cognitive skills.
Education level affects cognitive function level , but did not affect cognitive decline.
Education level and age significantly contributed to the prediction of the MMSE scores and explained @percent@ of its variance.
Education level in and of itself does not appear to be a valid indicator of cognitive reserve.
Education level is a potentially protective factor explaining these differences , but results on its effects on VCI are inconclusive.
Education level may contribute to this risk or it may be a surrogate marker for other factors contributing to depressive symptoms in this group.
Education may also promote problem-solving skills leading to reduced biological stress responsivity , with favorable consequences for biological aging.
Education , occupation attainment , and leisure activities were found to contribute differently to reserve capacity.
Education of a medical director has been shown to improve the quality of the nursing home.
Education of health care providers and medication review should be considered to improve medication safety of older adults.
Education of shipboard crews is required about possible severe health effects due to sun exposure at sea.
Education of smokers about effective smoking cessation methods and change in reimbursement policy are suggested to stimulate evidence-based smoking cessation practice.
Education-related inequities in need-standardised DMP enrolment favoured groups with lower education , but HII estimates were not significant.
Education , self-reported income adequacy , and self-reported income satisfaction were used as measures of social position.
Education that awakenings are part of normal sleep may have preventative health implications and reduce sleep anxieties.
Education was associated with more formal care.
Education was no longer associated with use of VFMO in @number@ where as age and comorbidities were.
Education was not significantly associated with every cognitive outcome , nor was age cohort membership.
Educators , policy makers , and nursing leaders need to clearly develop strategies to sustain Australian nursing scholarship for the future.
EDV and FMD were both significantly related to the occurrence of cortical , but not lacunar infarcts.
EDV increased significantly in early aging group to normal aging group and delayed aging group.
ED visit and hospital admissions at the @number@ primary referral hospitals for the practice were reviewed for chief complaint and discharge plan.
ED visit characteristics were described according to age group and year.
ED was more severe among MetS patients.
Edwin Cortez , Fred Fedok , and Devinder Mangat address questions for discussion and debate.
ED , with more than @number@ million sufferers in the world , has become a serious disease besetting the male patients.
EE also alters physiological responses and induces neurobiological changes such as stimulation of neurogenesis and neural plasticity.
EEG cortical sources from spectral analysis showed significant differences in delta , theta , and alpha @number@ bands.
EEG cortical sources were estimated by low-resolution brain electromagnetic tomography.
EEG recordings during the autoscopic experience showed a right parietal epileptic focus.
EEG rhythms of interest were alpha @number@ ( 8-10.5 Hz ) and alpha @number@ ( @date@ Hz ) .
EEG signals recording during rest condition from @number@ young subjects and @number@ mid-aged adults were studied.
EEG was recorded at the end of surgery and throughout emergence.
EEP consisted of a 10-station circuit of cardiovascular endurance , flexibility , coordination , abdominal and pelvic floor muscle exercises.
E / e ' ratio increased with ageing.
EET depressed genes encoding mitochondrial and metabolic transcripts.
EF402172 s and EF404388 s , as well as low LPS levels may play an important role in preserving residents ' health in LVC.
EF and MEM composite scores were measured at baseline , @number@ @number@ @number@ and @number@ months.
Effective antioxidant therapy requires prior knowledge of the type ( s ) of oxidative stress occurring in real time in the inner ear.
Effective antiviral agents for the treatment and vaccines for prevention of RSV remain a significant unmet medical need in the older adult population.
Effective behavioral and pharmacological therapies are available to treat sleep disturbances of different etiologies.
Effective care for such a cohort requires broad expertise from multiple disciplines delivered in a co-ordinated and managed way.
Effective chronic disease self-management has been shown to help patients improve their health condition.
Effective clinical therapeutics targeting this pathway remain unavailable.
Effective connectivity analyses were performed on the DMN to examine the effective connectivity modulation in these two different conditions.
Effective coping with the hardships and demands of caring may help to sustain the caregiver and lessen the effect of the stressors.
Effective diagnosis and treatment of the resultant pathologic conditions can be clinically challenging.
Effective diagnosis of the condition is dependent on a clear understanding of its underlying etiology.
Effective disease awareness campaigns have been implemented in some countries but need to be undertaken in many more.
Effective drug therapy for intestinal BD remains elusive.
Effective educational programs need to be developed , to support informed fertility and child-timing decisions.
Effective identification of this trouble allows adequate psychological interventions to improve the quality of life of these patients.
Effective improvement of photoaged skin , the possibility of repeated treatments and imitated side effects makes photodynamic therapy a promising procedure for skin rejuvenation.
Effective interventions have not been developed for or tested in this population.
Effective interventions included a population-wide education and promotion strategy , academic detailing for general practitioners , and inpatient geriatrician-led deprescribing.
Effective interventions should be determined to provide an approach solving the problem and improving the situation.
Effective interventions to reduce geriatric syndromes remain poorly implemented due to their complexity , and require an organised approach to change care practices and systems.
Effective length varied from @number@.5±2.6 mm ( L1 ) to @number@.6±3.3 mm ( L4 ) .
Effectively treating depressive symptoms and encouraging religious participation may improve QOL.
Effective management of care transitions for older adults require the coordinated expertise of an interprofessional team.
Effective management of chronic pain in this population is attainable , if properly recognized and treated.
Effective management of late life depression may potentially reduce incident cases of NCD in the population.
Effective management of PUD in the geriatric population relies on identification and modification of treatable risk factors.
Effective methods for long-term maintenance of behavior change are needed.
Effectiveness comparative to other analgesics has not been studied.
Effectiveness of sildenafil in patients on chronic hemodialysis as well as in patients undergoing radical prostatectomy is discussed.
Effectiveness of this type of reinforcement is strongly dependent on the type of mechanical loading.
Effectiveness outcomes included perioral , lip fullness , and oral commissure assessments and scores on the Cosmetic Improvement and Global Aesthetic Improvement Scales.
Effectiveness was also assessed.
Effectiveness was assessed through the improvement of anthropometric , metabolic , physical activity and dietary outcomes and number of goals met.
Effectiveness was measured in life years gained ( LYG ) .
Effectiveness was measured using biochemical markers.
Effective , physiologically relevant , phosphoproteome research relies on the efficient phosphopeptide enrichment from complex samples.
Effective postoperative pain treatment after geriatric day surgery requires careful pain assessment and drug titration.
Effective postoperative pain treatment after geriatric thoracic surgery requires careful pain assessment and drug titration.
Effective primary prevention strategies are clearly required.
Effective psychiatric treatments ameliorate excessive anxiety and induce neuroplasticity immediately after the intervention , indicating that emotional components in the human brain are rapidly adaptable.
Effective regeneration of the injured heart requires mobilization of hCPCs to the sites of damage.
Effective screening permits discovery of colorectal cancer at an early highly treatable stage and allows for detection and removal of premalignant colorectal adenomas.
Effective social functioning is reflected in the ability to accurately characterize other people and then use this information in the service of social goals.
Effective social welfare and health services aided by targeted government policies are needed to improve the quality of life of the elderly.
Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology.
Effective strategies will need to affect the social determinants of health in early life to influence inequalities into old age.
Effective teams , however , are not the result of chance but require careful planning and ongoing attention to team processes.
Effective therapies for these diseases are lacking.
Effective tools to study this impact are needed.
Effective topical management approaches for xerosis , fissures , hyperkeratotic lesions , and fungal infections can lessen the severity of symptoms.
Effective treatment can normalize these alterations.
Effective treatment can significantly reduce disability.
Effective use of topical treatments should be prioritized to ensure elderly patients can be effectively managed prior to advancing to photo- or systemic treatment modalities.
Effective vibratory noise amplitudes range from @percent@ to @percent@ of the sensory threshold and can be set once daily.
Effect modification by age was estimated by calculating relative excess risk due to interaction ( RERI ) .
Effect modification by EPA + DHA intake was tested for n-6 exposures.
Effect modification by gender was significant in this age group ( P = @number@ ) .
Effect of confounders such as gender , age , and ethnicity were checked using binary logistic regression.
Effect of fecal microbiota from donors of different age groups on the efficacy of FMT was also evaluated.
Effects for depressive symptoms , positive and negative affect , and life satisfaction were all in the beneficial direction but not statistically significant.
Effect size calculations for the interventions were provided where possible.
Effect size ( ES ) was calculated to determine which MADRS symptoms changed most during the treatment.
Effect sizes and odds ratios were calculated for primary and secondary outcome in the included studies.
Effect sizes ( Cohen's d ) for the differences were also computed.
Effect sizes ( d ) were calculated for the ability of parameters to discriminate between different frailty status groups.
Effect sizes for different types of items on the scale varied , with the largest gain seen in research methodology and communication of study findings.
Effect sizes for exercise and medication combined exceeded the effect sizes of either intervention in isolation.
Effect sizes for structural brain changes were not detectably different in accelerated versus nonaccelerated data.
Effect sizes ranged from @number@ to @number@
Effect sizes were calculated as Pearson r correlations using random-effects models.
Effect sizes were calculated only for the three studies which compared at least two different frailty status groups.
Effect sizes were moderate for symptoms of anxiety ( @number@ ) and small for depressive symptoms ( @number@ ) .
Effect sizes were small.
Effect sizes were small.
Effect sizes were smaller and nonsignificant in females ( HR = @number@ CIs [ @number@ @number@ ] ) .
Effect sizes were used to assess the impact of statistically significant criterion level non-invariance on the prevalence of GAD.
Effects may have been overestimated because of the low methodological quality of studies.
Effects of addiction , sex , myopia , aging , sleep deprivation on the three features were studied.
Effects of age and cardiovascular disease risk factors were evaluated by multivariable mixed regression and ANCOVA models.
Effects of age and hearing loss were limited to CAEP latency and were differentially modulated by energetic and informational-like masking.
Effects of age and hearing loss were observed in both listening environments , but varied with speaker accent.
Effects of age , gender , lens status , and diabetic status on these measurements were analyzed.
Effects of age were stronger in adolescence and emerging adulthood than in young adulthood and middle age.
Effects of aging-related factors in impairing homeostatic responses were developed from examples illustrating multiple determinants of clinical resilience outcomes.
Effects of cortical thickness and VBM results on cognitive and depression variables were also investigated.
Effects of demographic , clinical and equipment variables were assessed through meta-regression.
Effects of dialysis , aging and cell culture medium on the properties of the Q-dots and CS were also studied by luminescence and DLS techniques.
Effects of duration of diabetes , HbA₁ ( c ) and diabetic nephropathy were still continuing in multiple linear regression analysis.
Effects of either training modality on vascular function and biomarkers could not be confirmed.
Effects of GDS on cognitive decline in nondepressed cohorts may be driven by SCD rather than subsyndromal depression.
Effects of group , age , and their interaction on performance and select gray matter volumes were examined.
Effects of incentives on perceptual efficiency and response bias were estimated using the diffusion model ( Ratcliff , @number@ ) .
Effects of migraine medication use were also tested.
Effects of practice on a conflict task in elderly individuals are examined with a focus on its impact on executive function in working memory.
Effects of prior experience with PI depended on feedback given at the time of test ( Experiment @number@ ) .
Effects of skin wrinkling were studied independently or while coupled with age-related mechanical property changes.
Effects of smoking , obesity , and insulin resistance ( Sowers and colleagues ) impact the timing of the perimenopause transition in women.
Effects of supplementation on 1-year changes in 24h urine calcium concentration and urine volume were examined.
Effects of SWB facets were analyzed using Cox Proportional Hazards Models.
Effects of target schedule were not reliable.
Effects of the carrier phrase were minimal.
Effects of the emotional struggle involved in working with these older people were lessened by believing I did the right thing.
Effects of the interventions were evaluated with self-report psychological scales and questionnaires related to functional abilities and neuropsychiatric symptoms of the AD relative.
Effects on infraorbital rhytides were only slightly better ( P = .3531 ) .
Effects on performance and task-related brain activity were evaluated during overt semantic word generation , a task that is negatively affected by advanced age.
Effects range from smoothing superficial wrinkles to remodeling whole parts of the face.
Effects related to aging and duration of infection , but not central nervous system penetration effectiveness were observed.
Effects reported in previous studies might reflect incomplete control for stage at diagnosis and other factors associated with the use of statins.
Effects varied depending on the type of intervention.
Effects were comparable across middle- and older aged participants.
Effects were continuous over the entire IQ range.
Effects were expressed as differences in thyroid hormone levels associated with a doubling in the level of exposure.
Effects were independent , did not interact with age , and the cholesterol effect was restricted to males.
Effects were largely consistent across subgroups based on age , gender , race , body mass index , prior hospitalization , and selected chronic conditions.
Effects were more apparent with multi-week averages of exposures.
Effects were strongest on the ESR.
Effects were synergistic : the impact of the interaction of challenge variables was greater than the sum of independent effects.
Effects were tested in cortical surface-based analyses , with sex , age , follow-up interval , and the interactions between each included as covariates.
Efferent feedback shapes afferent auditory processing.
Efficacy.
Efficacy and tolerability are generally comparable between tolterodine and other newer antimuscarinics.
Efficacy , as well as adherence , may be affected by client religiosity.
Efficacy in subjects taking seven or more concomitant medications was similar to that in the overall pooled study population.
Efficacy of our iron withholding defense system is modulated by numerous environmental , behavioral and genetic factors.
Efficacy of P2X antagonists was assessed by flow cytometric measurements of ATP-induced ethidium + uptake in RPMI @number@ cells.
Efficacy of these treatments are not reviewed in detail but references for reviews and trials are provided for further reading.
Efficacy of the treatment was defined as total weight loss , percentage of initial weight and weekly weight loss rates.
Efficacy of treatment on corrugator supercilii muscles was measured by compound motor action potential ( CMAP ) and electromyography ( EMG ) .
Efficacy outcomes ( including changes in skin thickness and patient satisfaction ) and safety outcomes ( including mortality , lumps and infections ) were examined.
Efficacy , safety , and bacteriological evaluations were also carried out.
Efficacy was also measured by subjects ' self-assessments and via photography and instrumentation.
Efficacy was assessed by 24-hour ambulatory BP monitoring ( ABPM ) and SeBP measurements.
Efficacy was assessed in different ways.
Efficacy was assessed @number@ weeks posttreatment ( End of Study Visit [ EOS ] ) .
Efficacy was assessed on the Wrinkle Severity Rating Scale ( WSRS ) and the Global Aesthetic Improvement Scale ( GAIS ) .
Efficacy was based on a global photodamage score , photographs , and image analysis using replicas and Visiometers every @number@ weeks.
Efficacy was determined by calculating the change in Wrinkle Severity Rating Scale ( WSRS ) relative to baseline.
Efficacy was determined by rate , amount , and retention of training-related improvement , and compared across levels of cognitive status.
Efficacy was evaluated based on the change in Wrinkle Severity Rating Scale ( WSRS ) from baseline.
Efficacy was evaluated based on the change in Wrinkle Severity Rating Score ( WSRS ) from baseline.
Efficacy was evaluated based on the Wrinkle Severity Rating Scale and Global Aesthetic Improvement Scale.
Efficacy was evaluated by global photographic assessment , eyebrow diameter , eyebrow count and subject's satisfaction.
Efficacy was evaluated by patients and investigators using the Global Aesthetic Improvement Scale ( GAIS ) .
Efficacy was evaluated in patients with DLBCL.
Efficiency of enzyme treatment was quantified using dimethylmethylene blue assay.
Efficiency of the associated network was analyzed , comparing PD to healthy controls.
Efficiency reduction of sensory-perceptual mechanisms underpinned by these areas may partly be due to local atrophy.
Efficient and regular performance of Ubiquitin Proteasome System and Autophagy continuously eliminate deleterious accumulation of nonnative protiens.
Efficient autophagy is the major mechanism that moderates accumulation of aggregating compounds.
Efficient coupling of cellular energy production to metabolic demand is crucial to maintain organismal homeostasis.
Efficient degradation and replacement of dysfunctional mitochondria ensures cell survival , particularly in terminally differentiated cells such as cardiac myocytes.
Efficient execution of strategies is crucial to memory performance and to age-related differences in this performance.
Efficient motor control requires motor planning.
Efficient navigation of our social world depends on the generation , interpretation , and combination of social signals within different sensory systems.
Efficient osteogenesis from mesenchymal stem cells ( MSCs ) would have the clinical application potential in treating multiple osteal disorders.
Efficient processing of our complex visual environment is essential and many daily visual tasks rely on accurate and fast object recognition.
Efficient smooth-pursuit requires appropriate target selection and predictive compensation for inherent processing delays.
Efficient vascular repair requires functional adult stem cells unimpaired by aging or mutation.
Effluent dialysate can be drained repeatedly to measure concentration of various bioactive molecules and to correlate the results with the peritoneal permeability.
Efforts aimed at protecting and harnessing endogenous NSCs will offer novel opportunities for the development of new therapeutic strategies for neuropathologies.
Efforts are needed from health authorities and healthcare providers to promote the large-scale adoption of an active lifestyle throughout the life course.
Efforts are ongoing to ensure a definitive diagnosis is made ; which will be the first diagnosed case of progeria in Nigeria.
Efforts are underway to explore the therapeutic opportunities stemming from the intriguing relationship of UCPs and cancer.
Efforts are underway to identify the responsible genes for AWS with unknown genetic causes.
Efforts have been made to reflect the promulgated law in light of the contemporary developments taking place globally , particularly in regions of Asia.
Efforts like this are especially important because the baby boomer population is aging into the years when strokes are more common.
Efforts must be made to nurture locally wanted physicians through specific efforts concerning team-based medicine.
Efforts should be directed at assessing manpower requirements in head and neck surgery based on the impact of an aging US population.
Efforts should be made to increase men's awareness of hypertension.
Efforts should be made to reduce stigma surrounding continued sexual activity and expression among the aged.
Efforts should be made to reduce stigma surrounding continued sexual activity and expression among the aged.
Efforts that focus on salt reduction are needed to address this important public health problem.
Efforts that target employers and workplaces as important stakeholders in the prevention of suicide and link the unemployed to mental health resources are warranted.
Efforts to expand the global oncologic workforce and reduce preventable factors may lessen cancer disparities in developing countries.
Efforts to explore reserve have been hindered by measurement difficulties.
Efforts to identify and update incidence estimates for anemia-associated nutrient deficiencies in aging women should be undertaken.
Efforts to identify which factors influence physical activity behaviour are needed.
Efforts to improve the identification of elder abuse in EDs may be warranted.
Efforts to improve work quality and availability for older workers are urgently needed , particularly in physically demanding occupations.
Efforts to increase general health screenings and improve access to chronic condition management resources are hampered by a lack of disease and health awareness.
Efforts to increase physical activity levels in this population are warranted.
Efforts to induce robust fibroplasia in histologic specimens and skin tightening in the clinical setting have yielded inconsistent results.
Efforts to lower cumulative medical burden in the geriatric population may benefit cognitive function.
Efforts to optimize appropriate use of SNF services in individuals with advanced dementia should focus on these factors.
Efforts to prepare for this increase including manpower planning and education appear imperative.
Efforts to promote bone health may benefit from focusing on men with low education levels and women with low individual income.
Efforts to promote healthy aging should focus on preventing obesity and maintaining muscle mass.
Efforts to reduce perioperative complications are therefore imperative , especially for elderly ASD patients in our aging society.
Effusion , particularly , pericardial effusion significantly influenced the prognosis , so that it should be effectively controlled.
EF problems contributed to lower adaptive behavior scores across domains.
EFs was assessed via Trail Making Test , semantic fluency , and phonemic fluency.
EFT was measured by transthoracic echocardiography , and CIMT and FMD were measured with standard procedures.
EFV and CAC were significantly correlated with the traditional risk factors like age , male gender , diabetes , smoking and hypertension.
EF was assessed on a physician-reported three-point scale.
EF was represented by a 1-factor structure.
EG and ginsenoside F2 are potentially useful for the prevention and treatment of UVB-induced skin damage.
EG , an extract which is rich in the active compound ginsenoside F2 , and purified ginsenoside F2 were used in these experiments.
EGb also suppressed IL-1-stimulated iNOS expression and release of nitric oxide ( NO ) .
EGCG facilitates the interaction between TAZ and MyoD , which stimulates MyoD-mediated gene transcription.
EGCG induced DNA double-strand breaks and apoptosis in normal cells and enhanced the mutation frequency.
EGCG induces nuclear localization of TAZ through the dephosphorylation of TAZ at its Ser89 residue , which relieves 14-3-3 binding in the cytosol.
EGF and FGF1 have considerable potential as possible therapeutic or cosmetic agents for the treatment of skin damage including wrinkles.
EGFR and c-MET mutations were mutually exclusive.
EGF re-induced Akt phosphorylation at Thr308 in the AIM-treated cells , but not Akt phosphorylation at Ser473.
EGFR / ErbB1 expression is detected in the majority of NPC tumors with advanced disease.
EGFR-mutated patients tended to be female and non-smoker and experienced a prolonged OS suggesting a possible positive prognostic effect. c-MET mutations did not affect survival.
EGGL removal may have benefit for acute fibrotic diseases , such as tendinopathy , and for treating generalized decline in ECM function with old age.
Eggs and fish are higher melatonin-containing food groups in animal foods , whereas in plant foods , nuts are with the highest content of melatonin.
E group.
EGT can accumulate in the body at up to millimolar concentrations and is believed to function as a physiological antioxidant.
E-HDL and gA-I-rHDL exacerbated cellular senescence and atherosclerosis with increased cellular cholesterol influx.
Eicosanoids reflect inflammation , oxidant stress , and vascular health and vary by sex and metabolic parameters.
Eicosapentaenoic acid and blood pressure showed no effects.
EIF2AK3 encodes PERK , part of the endoplasmic reticulum's ( ER ) unfolded protein response ( UPR ) .
Eigenvector @number@ accounted for @percent@ of the variance observed among all of the meibum spectra.
Eight- and 10-month-olds most often grasped the handle while looking at the ball , and showed clear surprise in the trick condition.
Eight articles reported dietary intake and seven demonstrated an improvement , with protein intakes at volunteer mealtimes increasing by @number@.3g-10.1g and energy intakes by 44-105kcal.
Eight articles were included and results show there were few consistencies between intervention types , groups , outcome measures , and follow-up.
Eight artists first generated age progressions of eight targets across three age ranges.
Eight cases were excluded because of non-qualification.
Eight chemokines in urine were measured by MILLIPLEX MAP human cytokine / chemokine multiplex immunoassay and ELISA.
Eight cognitive tests designed to evaluate several cognitive domains including memory and processing speed were administered.
Eight critically ill patients with a diagnosis of septic shock participated in this short-term ( @number@ h ) dose-response study.
Eighteen adults ( ten younger , 22-24 years old , and nine older , 51-67 years old ) were tested.
Eighteen cohorts with a total of @number@ participants were meta-analyzed.
Eighteen community-dwelling older adults ( ages 65-85 ) were randomly assigned to an intervention or control group.
Eighteen miRNAs were differentially expressed in older humans ( P < @number@ and > 500 expression level ) .
Eighteen out of @number@ patients completed the study.
Eighteen participants ( 60-77 years ) were randomly assigned to two groups.
Eighteen patients ( @number@ % ) transmitted no warning event and accepted no parameter adjustment during observation.
Eighteen peptides consisting of @number@ transitions were monitored and validated in pooled human plasma.
Eighteen percentage of venous variations were found out of the @number@ dissection performed.
Eighteen percent and @percent@ of older Chinese men met the eligibility criteria for appropriateness for CMS and USPSTF LDCT screening , respectively.
Eighteen percent of incident malignancies in the United States are a second ( or subsequent ) cancer.
Eighteen single-nucleotide polymorphisms ( SNPs ) in FOXO3 were successfully genotyped in @number@ unrelated long-lived individuals and @number@ younger controls.
Eighteen studies detected LC in the morning in a FS , @number@ studies denoted the r between leptin and the BMI.
Eighteen studies investigating @number@ Single Nucleotide Polymorphisms ( SNPs ) in relation to zinc intake and / or status were identified.
Eighteen studies met inclusion criteria for systematic review , of which @number@ for further meta-analyses.
Eighteen subjects had all three microvascular complications of diabetes.
Eighteen subjects ( @percent@ ) had microalbuminuria , and two subjects ( @percent@ ) had macroalbuminuria.
Eighteen subjects were diagnosed with subclinical RBD , and the prevalence of subclinical RBD was estimated to be @percent@.
Eighteen women were referred for care.
Eighteen young subjects performed 30-s postural trials on one leg with their eyes closed.
Eight falls were investigated using the systemic falls investigative method.
Eight families of seniors suffering from chronic disease took part in the research.
Eight focused on physical activity , fourteen on cognitive interventions , and one on the effects of socialization.
Eight fresh and fixed cadavers with evidence of perioral fullness were used in anatomical dissection.
Eight geriatric conditions : cognitive impairment , falls , incontinence , low body mass index , dizziness , vision impairment , hearing impairment , pain.
Eight had bone sarcoma and @number@ had soft tissue sarcoma.
Eight healthy male volunteers performed @number@ maximal eccentric contractions with each leg.
Eight hundred eight faculty , representing @number@ schools of nursing , attended.
Eight items were deleted so that the final version of CBE-SR comprises @number@ items.
Eight Listening Sessions were held across New York State to obtain input on topics including training , gerontology education , and credentialing and certification.
Eight non-related families featured the founder mutation COL4A3-p. ( G1334E ) .
Eight of the @number@ frequently unanswered items were marked as difficult to understand by the patients.
Eight participants with probable Alzheimer's disease ( AD ) were trained to recall names of countries using the spaced-retrieval memory intervention.
Eight patients and @number@ elderly adults repeated this task to obtain longitudinal data.
Eight patients had azole-resistant IA after HSCT , and seven of the cases were fatal ( @percent@ ) .
Eight patients had bilateral AVN.
Eight patients ( @percent@ ) were less than @number@ years while @number@ patients ( @percent@ ) were between @number@ and @number@ years.
Eight percent of subjects had an AHI > 15 / h.
Eight ( @percent@ ) reoperations were at the index level.
Eight RCTs compared WBV-only with control and eight RCTs compared WBV-plus-exercise with the same-exercise only group.
Eight RCTs met the criteria including @number@ RCTs for stroke and @number@ for Parkinson disease.
Eight revision operations were required for undercorrection.
Eight selected miRNAs were analyzed in hippocampus , and the expression of miR-16 , miR-34c , miR-107 , miR-128a , and miR-146a were differentially regulated.
Eight seniors participated in the study.
Eight SNPs were typed in both populations.
Eight studies found no difference in efficacy between incobotulinumtoxinA and other BoNTAs.
Eight studies met the eligibility criteria and included @number@ RCTs , @number@ CT , and @number@ UT.
Eight studies offered data for meta-analysis.
Eight studies ( @percent@ ) were of high methodological quality.
Eight studies were enrolled , comprising @number@ ALS patients and @number@ HC.
Eight subjects in the conservative treatment group switched to the PRF group after @number@ weeks , and six of them had > 50% improvement.
Eight subjects ( @percent@ ) had fallen within the past year , and @number@ subjects ( @percent@ ) had fear of falling.
Eight Teaching Teams , designated and trained by AMA staff , offered @number@ training sessions across the United States in @number@ to @number@
Eight-two percent of new cases in @number@ occurred in individuals aged @number@ yr and older.
Eight weeks of CPAP seems to improve gait of OSA patients that are specifically disturbed by the dual task of verbal fluency.
Eighty community-dwelling patients ≥45 years old demonstrating durable viral suppression were evaluated.
Eighty composite cylinders were bonded to pretreated ceramic slices using a bis-GMA-based resin cement.
Eight-year cognitive change was assessed in @number@ cognitively normal community-dwelling adults aged 20-24 , 40-44 , or 60-64 years at baseline.
Eight-year longitudinal data showed that salt intake decreased in men.
Eight-year-olds performed at mature levels.
Eighty-eight older adults ( mean age = @number@ years , SD = @number@ ) participated in the study.
Eighty-eight participants had full data available.
Eighty-eight per cent of clinics claimed treatment effectiveness , with @percent@ describing their curative potential.
Eighty-eight ( @percent@ ) participants had an FI score ≥ @number@ and @number@ ( @percent@ ) had a score ≥ @number@
Eighty-five consecutive Fontan patients ≥10 years who performed adequate cardiopulmonary exercise testing ( respiratory exchange ratio > 1.01 ) were included.
Eighty-five males performed four 15-min bouts of cycling separated by 15-min rest periods , in a calorimeter regulated to 35°C and @percent@ relative humidity.
Eighty-five percent of the participants completed all of the follow-up data points.
Eighty-five persons ( @percent@ ) developed new microbleeds.
Eighty-four percent of the younger age group and @percent@ of seniors reported positive tendencies on four or more of these factors.
Eighty-four percent reported interacting with older adults at least monthly ; @percent@ reported daily interactions.
Eighty-nine percent of officers reported interacting with older adults at least monthly.
Eighty-nine percent responded that the items were relevant and @percent@ that no item should be excluded.
Eighty of @number@ articles met these criteria.
Eighty-one facilities improved across most domains and @number@ facilities declined.
Eighty-one healthy , community dwelling adults aged 70±3 participated.
Eighty-one male runners underwent an incremental test to exhaustion.
Eighty-one middle-aged and older adults ( @number@ men and @number@ women ) aged @number@ to @number@ years volunteered for the study.
Eighty one percent of patients with an advanced polyp met the criteria for MetS.
Eight young ( 19-28 years old ) and eight older ( 62-81 years old ) healthy males participated in neuromuscular testing.
Eighty patients survived to discharge and nine died.
Eighty percent of the patients were either \ "satisfied \ " or \ "very satisfied \ " with the results.
Eighty reflective journals completed by a sample of @number@ students following visits with their designated older adult were also analysed.
Eighty seven adult subjects who were free of vasoactive agents were included.
Eighty-seven elderly females were involved.
Eighty-seven healthy older adults took the NEO Personality Inventory and had brain MRI at two time points @number@ years apart.
Eighty-seven percent of EEE veterans attended an appointment within @number@ months , compared to @percent@ of AO veterans ( P < @number@ ) .
Eighty-seven percent of I-ADNI MPRAGE images were ranked of high quality in comparison of @percent@ of NA-ADNI.
Eighty-six charts were reviewed , @number@ for Group @number@ and @number@ for Group @number@
Eighty-six participants returned for a second visit.
Eighty-six percent of patients were overall satisfied to very satisfied with the treatment.
Eighty-three had SDB and were not using continuous positive airway pressure therapy.
Eighty-three percent of residents had a history of dementia and @percent@ were taking antipsychotic medications.
Eighty-three percent of studies found at least one positive relationship between these factors ; however , findings were variable.
Eighty-two participants ( 40-50 years , ±2 ) were assessed with a comprehensive neuropsychological battery covering a broad spectrum of cognitive domains and components.
Eighty-two women reported using absorbent products.
Eighty young and @number@ healthy older adults were included in this study.
EI is thought to be important for social life making it a popular subject of research.
Either an orbital fat transposition flap or a dermofat graft was applied , according to the severity of the deformity , with successful results.
Either ANP ( @percent@ ) and BNP ( @percent@ ) were significantly higher in PE patients than in controls.
Either can materially impact equilibrium enrollments , especially when premiums to enrollees reflect these costs.
Either HIV or other factors that differ between older HIV-infected participants and healthy controls could be responsible for these differences.
Either MEK or mTOR was sufficient to phosphorylate these PMA-induced rapamycin-resistant sites because co-treatment with U0126 and rapamycin was required to abrogate them.
Either no sound , steady state noise , or competing speech was presented to the other ear.
Either or both ways , the normal protein homeostasis in the cell is affected , resulting in aberrant and misfolded proteins.
Either teenage or advanced parental age is associated with risk of birth and health outcomes in offspring.
Ejaculations per week / satisfaction with sex life rose over the first @number@ weeks , increasing steadily to a plateau at @number@ weeks.
Ejaculation time was not associated with serum testosterone levels.
Ejection fraction was preserved in @percent@ of patients , reduced in @percent@ , and missing in @percent@.
Elaborate developmental processes starting in utero herald connectome genesis , with dynamic changes in its architecture continuing throughout life.
Elastic arteries are significantly prestretched in an axial direction.
Elastic characteristic parameters , like Young's modulus of elasticity ( E ) derived from a traditional cylindrical model , increase significantly with aging.
Elastic fibers were identified in all specimens ; however , all were of abnormal morphology.
Elasticity is lost in fibrotic cerebral vessels , reducing the response of stiffened blood vessels in times of increased metabolic need.
Elasticity measurements of the capsule were performed with a laboratory-built AFM system custom designed for force measurements of ophthalmic tissues.
Elastic properties and moisture content were also compared between the lower labial mucosa and skin.
Elastic properties ( distensibility and elasticity ) and moisture content of lower labial mucosa and skin were determined in each participant.
Elastin and collagen fibers can be observed using state-of-the-art multi-photon microscopy.
Elastin is a long-lived protein and a key component of connective tissues.
Elastin is such a durable protein.
Elastin-stained carotid arteries were analyzed to assess age-related structural changes in @number@ deceased individuals.
Elastograms were further evaluated by histogram analysis.
Elastography scores were assigned to each clip based on a five-point color scale.
Elbow arthroplasty provides good pain relief but functional outcomes are not nearly as good , and significant potential complications exist.
Elbow flexor compartment , medial head of gastrocnemius and vastus lateralis muscle were investigated.
Elbow tendinopathy accounts for the majority of elbow pathology in patients presenting to upper extremity and sports medicine surgeons.
ELBW neonates display trends similar to heavier neonates , but peak Scr is higher , and the subsequent decrease slower.
Elder abuse appears to be widely underestimated by health professionals.
Elder abuse ( EA ) case resolution is contingent upon victims accepting and pursuing protective service interventions.
Elder abuse is an important public health and human rights issue , yet its true extent is not well understood.
Elder abuse is a public health problem growing more pervasive despite being grossly underreported and underdetected.
Elder abuse subtypes and depression dimensions were differentially associated.
Elder abuse was assessed by a 10-item instrument derived from the Caregiver Abuse Screen ( CASE ) .
Elderburbs-older , age-unfriendly communities not focused on residents ' health care and mobility needs-remain and can present unique problems.
Elderly adults , little studied in this regard , face particular risk.
Elderly adults showed a decrease in accuracy when grasping objects presented in the peripheral , but not in the central visual field.
Elderly AF patients are undertreated with vitamin K antagonists ( VKA ) .
Elderly AML patients referred to PC service were included.
Elderly are more likely to be cirrhotic and asymptomatic at presentation.
Elderly are more prone to postoperative complications.
Elderly are the most vulnerable population group owing to increased prevalence of chronic diseases and drug consumption.
Elderly exhibited significantly greater GR than young participants ( P = @number@ ) .
Elderly fallers adopted a movement strategy that included a posterior foot placement at seat-off , a longer duration , and a shorter initial step length.
Elderly Greek-born Australians ( GA ) consistently show lower rates of all-cause and CVD mortality compared with Australian-born.
Elderly healthy individuals found it most difficult to learn the last category.
Elderly humans show decreased humoral immunity to pathogens and vaccines , yet the effects of aging on B cells are not fully known.
Elderly individuals account for the largest and the most rapidly growing age segment of the end-stage renal disease population.
Elderly individuals and dementia patients commonly experience disrupted sleep-wake cycles , which may lead to psychomotor agitation , confusion , and wandering.
Elderly individuals are more susceptible to new threats and are less able to control endogenous infections.
Elderly individuals display a rapid age-related increase in intraindividual variability ( IIV ) of their performances.
Elderly individuals gradually modify their strategy based on previous successes and failures during daily living to compensate for their decline in dexterity and operational capabilities.
Elderly individuals produced pressure longer during control swallows in the oropharynx and hypopharynx than young individuals.
Elderly individuals tend to go to sleep earlier in the evening and wake earlier due to a phase advance in their normal circadian sleep cycle.
Elderly individuals , therefore , often require further objective tests , including bronchial challenge testing , to objectively confirm asthma.
Elderly individuals with certain mental symptoms should be targeted for suicide prevention and provided with timely mental health support.
Elderly Korean men and women had very similar cutoff points for both VFA and WC measurements for estimating the risk of MetS.
Elderly male patients are also subject to QTc interval prolongation when such risk factors are present.
Elderly may have insufficient awareness of the balance threat caused by muscle fatigue.
Elderly men with androgen deficiency are exposed to osteoporosis and can be treated with testosterone replacement.
Elderly-onset sarcoidosis ( EOS ) is defined as the onset of sarcoidosis in people over @number@ years of age.
Elderly participants as compared to young participants showed increased P1 amplitude while their P2 amplitude was reduced.
Elderly participants displayed more significantly activated channels and a different activation pattern compared to younger participants especially manifesting in more bilateral dlPFC activation.
Elderly participants showed lower symmetry and regularity in their gait than young participants.
Elderly patients ( aged 80-89 years ) diagnosed with PE served as controls.
Elderly patients ( age ≥ @number@ years ) with hypertension are at high risk for vascular complications , especially when diabetes is present.
Elderly patients and patients with renal impairment present unique challenges in the management of diabetes mellitus.
Elderly patients are a heterogeneous population in terms of physical reserve , comorbidity , polypharmacy , and other geriatric conditions.
Elderly patients are also more susceptible to adverse reactions of medication , drug interactions and other drug problems than the young.
Elderly patients are a rapidly growing subset of the kidney transplant waiting list.
Elderly patients are characterised by great inter-individual variability in physiological function with a high prevalence of chronic disease.
Elderly patients are often affected by multiple organic diseases which can interfere with sexual function.
Elderly patients are often considered high-risk surgical candidates.
Elderly patients constitute a heterogeneous population including a significant group of relatively fit patients who ought to benefit from the conventional treatment.
Elderly patients experienced more in-hospital bleeding complications requiring blood transfusion ( @number@ vs. @percent@ ; p = @number@ ) .
Elderly patients have markedly less physiologic reserve than do younger patients , and comorbidity is common.
Elderly patients have unique characteristics that make dosing vancomycin a challenge for clinicians , such as increased volume of distribution and decreased renal function.
Elderly patients may experience impairments in cognition or mood following surgery.
Elderly patients may represent an important group when considering new stroke treatments , particularly in developing countries.
Elderly patients may require focused clinical care that extends beyond HIV treatment.
Elderly patients often enter critical illness with reduced muscle mass and function and are also at increased risk for accelerated disuse atrophy with acute illness.
Elderly patients often suffer from multiple age-related diseases.
Elderly patients potentially are more complicated to treat than younger HIV-infected individuals because of comorbidities and the physiological effects of aging on pharmacokinetics and pharmacodynamics.
Elderly patients presented more in-hospital complications ( @percent@ versus @percent@ ) and higher mortality rates ( @percent@ versus @percent@ ) .
Elderly patients represent a huge market for the pharmaceutical industry because population is aging and multimorbidity is concentrated on the last years of life.
Elderly patients require a comprehensive , holistic approach to a variety of problems that occur with aging.
Elderly patients require individualized treatment modalities , which take the extent of comorbidities and personal environment into consideration.
Elderly patients should not be considered ineligible for surgical treatment due to their age alone.
Elderly patients tend to present with multiple complications that should be considered by the management team.
Elderly patients were more likely to be women , infected with hepatitis C virus , and score better in the Child-Pugh classification.
Elderly patients were the primary population with AKI , and the most common type of AKI was pre-renal AKI.
Elderly patients with acute pulmonary embolism ( PE ) have higher mortality than non-elderly patients , but receive systemic fibrinolysis less frequently.
Elderly patients with advanced NSCLC treated with platinum doublet therapy demonstrate similar efficacy ( but increased toxicity ) to their younger counterparts.
Elderly patients with age-associated co-morbidities have an increased risk for conventional mitral valve surgery.
Elderly patients with CLL are heterogeneous with regard both to the biology of their disease and aging.
Elderly patients with GERD often require long-term acid suppressive therapy.
Elderly patients with non-Hodgkin lymphoma ( NHL ) have a poor prognosis.
Elderly people are prone to orthostatic intolerance , but the impact of endurance training in old age has been insufficiently explored.
Elderly people at risk of suicide are vulnerable : they feel degraded if their autonomy is threatened by health personnel.
Elderly people experience solitude as isolation , even more so when the person is ill.
Elderly people have increased susceptibility to infections and cancer that are associated with decline in cellular immune function.
Elderly people have multi-morbidity with numerous medical conditions and use many medical resources for complex treatment patterns.
Elderly people must be treated with dignity and spared from the prejudices which currently surround old age.
Elderly people must have control over their own lives up until the end and we must open ourselves up and accept them in their entirety.
Elderly people often suffer from sarcopenia in their lower extremities , which gives rise to the increased susceptibility of fall.
Elderly people receiving care deserve special attention regarding drugs that are appropriate for their age group.
Elderly people suffer from more severe infections than younger persons.
Elderly people , those above @number@ or @number@ years old differ from younger people in many ways.
Elderly people usually have multiple chronic diseases concurrently.
Elderly people usually suffer from age-dependent diseases , and such polymorbidity can seriously affect the treatment of malignant tumors.
Elderly people who are alone and dependent in fulfilling their ADL should be monitored more closely.
Elderly people who are left behind may experience a decrease in welfare when their children migrate.
Elderly people will only profit , if these guidelines are used in daily routine.
Elderly people with asthma showed more marked airway obstruction compared with young people with asthma and elderly people without asthma.
Elderly people with higher BMI had lower total energy expenditure and lower intensity and shorter physical activity duration than elderly people with lower BMI.
Elderly , @percent@ , were more likely to present asymptomatically , cirrhotic at presentation and HLA-DR4-positive.
Elderly persons are more susceptible to RSV-induced pneumonia than young people , but the molecular mechanism underlying this susceptibility is not well understood.
Elderly persons often neglect UI or dismiss it as part of the normal aging process.
Elderly ppsclera DOFA was higher than that in young ppsclera ( p < @number@ ) , and generally higher than in glaucoma ppsclera.
Elderly showed higher BOLD-responses in a frontoparietal network , pointing to an increased reliance on sensory feedback processing.
Elderly showed increasingly more difficulties focusing attention on the left ear ( LE ) with advancing age.
Elderly subjects followed both saccadic and pursuit targets with less accuracy than young subjects.
Elderly subjects showed larger CI in both speed conditions than did the young subjects.
Elderly subjects with severe AS and a cohort of patients without AS of similar age were studied.
Elderly TNBC patients received significantly less chemotherapy than younger patients ( p < 0.001 ) .
Elderly trauma patients present unique challenges and face more significant obstacles in recovery compared to younger patients.
Elderly urologic patients require the same cautions as used in development of treatment programs for them in other disciplines.
Elderly was defined as @number@ years or older.
Elderly were defined according to age ≥ @number@ years.
Elderly who shopped every day have @percent@ less risk of death than the least frequent shoppers.
Elderly with dementia are especially susceptible to abnormalities of their electrolyte and body water homeostasis and should be ( re- ) assessed for polypharmacy.
Elderly with late-onset recurrent respiratory tract infections ( RRTI ) often have specific anti-polysaccharide antibody deficiency ( SPAD ) .
Elderly with mild disability are more likely to be treated at home than before , whereas severely disabled individuals continue to receive institutional LTC.
Elderly women and older elderly individuals compared with elderly men and younger elderly should be considering as an important risk factor for reducing HRQOL.
Elderly women classified as frail , pre-frail , and non-frail presented @percent@ , @percent@ , and @percent@ positivity for CMV , respectively.
Elderly women responded with less increase in heart rate but with equal forearm vascular resistance ( % ) response during LBNP.
Elderly women who reported two or more falls throughout the follow-up period were considered as recurrent fallers.
Elder participants showed a negative correlation for the ipsilateral supplementary motor area ( SMA ) and for the ipsilateral sensorimotor cortex ( SM1 ) .
Elder satisfaction with the nursing home and nursing home staff were also examined.
Elder self-neglect is a global public health and human rights issue that threatens older people's health and safety.
Elders ( N = @number@ ) were compared on the Barriers to Being Physically Active Quiz after participating in a pilot physical activity trial.
Elders showed higher levels of spontaneous intracellular ROS content compared with young and nonagenarian groups , which had similar intracellular ROS levels.
Eldest children , compared to other siblings , provided the most end-of-life caregiving to their parents.
E-learning and serious games programs may enhance public and professional education.
Elective orthopedic surgeries of the bones and joints also represent some of most common forms of elective surgeries performed.
Electoral rolls were used to invite women in @number@ towns to participate ( participation rate @number@ % ) .
Electrical impedance measurements of skeletal muscle may be sensitive to age-associated declines in muscle health.
Electrical source imaging showed that the changes in the scalp potential resulted from decreased activity in lateral occipital cortex and increases in fronto-parietal areas.
Electrocardiogram ( ECG ) showed poor R progression , ST elevation , negative T in precordial leads , and marked QT prolongation.
Electroencephalogram showed typical AS patterns in 35 / 46 ( @percent@ ) .
Electroencephalograms were recorded while humans listened to two spoken digits against a distracting talker and decided whether the second digit was smaller or larger.
Electroencephalogram was recorded to assess the underlying patterns of oscillatory activity , a neurophysiological mechanism advanced to support the integration of sensory reafferences.
Electroencephalographic spectral analysis was performed using the C3 / A2 channel.
Electroencephalography ( EEG ) is a powerful method of studying the electrophysiology of the brain with high temporal resolution.
Electroencephalography ( EEG ) power is an advantageous technique to assess infant functional neural activation.
Electroencephalography investigations were carried out twice in @number@ schoolchildren in the age of 7-8 years and in the age of 9-10 years.
Electrolyte disorders and hemodynamically caused perfusion deficits are more frequent in old age and are often caused by medication.
Electromyograms were obtained from the right TA , soleus ( SOL ) , and medial gastrocnemius ( MG ) muscles.
Electromyogram was measured on the gluteus medius muscle and abduction torque was measured.
Electromyographic and dynamometric recordings were made and analyzed using the , assessment of peak EMG-activity and peak force.
Electromyographic evaluations of the tibialis anterior and soleus were recorded.
Electromyography ( EMG ) data were collected from the tibialis anterior and soleus during walking to calculate the co-contraction index ( CI ) .
Electromyography was performed at baseline and Days @number@ and @number@ and ultrasound was performed only at baseline.
Electronic databases and reference lists of identified papers were searched until @date@ .
Electronic databases including MEDLINE , EMBASE , Cochrane library , and Ageline will be searched from inception to @date@ to identify relevant studies.
Electronic databases including Medline ( @number@ to @date@ ) and EMBASE ( @number@ to @date@ ) were searched via Ovid SP.
Electronic prescription database software may help to prevent inappropriate prescribing and minimize the occurrence of adverse drug reactions.
Electronic search at PubMed , EMBASE , Weipu database , and Wanfang database was conducted to select studies.
Electronic searches were carried out up to @date@ .
Electronic searches were carried out up to @date@ .
Electronic searches were conducted in PubMed , Embase , PsycINFO , CINAHL , Cochrane Library , Proquest Dissertations and Theses , and WorldCatDissertations.
Electron microscopy analysis of both , KS skin biopsies and keratinocytes showed marked morphological mitochondrial abnormalities.
Electron microscopy evaluations showed a clear dermal remodeling in relation with the activation of fibroblast activity.
Electron microscopy images of old C. glabrata cells indicate a marked increase in cell wall thickness.
Electron microscopy revealed abundant , enlarged and abnormally shaped mitochondria.
Electrophilic compounds have been shown to be activators of these transcription-mediated responses through S-alkylation of specific regulatory proteins.
Electrophoretic mobility shift and chromatin immunoprecipitation assays show that FoxO1 binds to the IRS-1 and FKHD-L sites of the SIRT1 promoter.
Electrophoretic mobility shift assays revealed abundant complexes in senescent cell nuclear extracts compared with young cell nuclear extracts.
Electrophysiological analysis shows for the first time that secreted eTau causes neuronal hyperactivity.
Electrophysiological : augmented N1 was found in the 2G condition ( independent of age group ) .
Electrophysiological features of HNPP has been found progressing with aging.
Electrophysiological results revealed an interaction between tapping condition and age group on low beta band ( 14-20 Hz ) activity.
Electrophysiology and behavioral measures were strongly correlated.
Electrophysiology revealed an increased variation of FRDA- cardiomyocyte beating rates which was prevented by addition of nifedipine , suggestive of a calcium handling deficiency.
Electrotherapy showed some beneficial effect in the treatment of PUs , although the quality of evidence is low.
Electrothermal bipolar coagulation appears to significantly reduce blood loss during these surgeries.
Elevated abdominal obesity and low HDL-C are the main players affecting arterial stiffness in the middle-aged and elderly Chinese.
Elevated ALP in postmenopausal women is mainly caused by high bone turnover.
Elevated amyloid-β peptide ( Aβ ) in brain contributes to Alzheimer's disease ( AD ) pathogenesis.
Elevated antibody levels were accompanied with decreased surface nAChRs on the blood lymphocytes of children and of mice immunized with α7 ( 1-208 ) .
Elevated anxiety , mean arterial pressure , and salivary cortisol levels in both men and women did not explain the greater fatigability during high CD.
Elevated %BF was associated with reduced mortality from cardiovascular causes ( HR @number@ [ @number@ @date@ ] ) .
Elevated brain iron content , which has been observed in late-stage human Alzheimer's disease , is a potential target for early diagnosis.
Elevated CCN1 rapidly induces IL-1β , inhibits type I collagen production , and upregulates matrix metalloproteinase-1 , which degrades collagen fibrils.
Elevated cerebrospinal fluid protein and abnormal nerve conduction were frequently observed in both sporadic and familial NIID cases.
Elevated cholesterol has been linked to psychiatric disorders and has been shown to be a risk factor for AD and to impact disease progression.
Elevated cingulo-opercular activity was associated with an increased likelihood of correct recognition on the following trial independently of SNR and performance on the preceding trial.
Elevated circulating levels of glucocorticoids are associated with psychiatric symptoms across several different conditions.
Elevated cortisol levels have been hypothesized to contribute to cognitive aging , but study findings are inconsistent.
Elevated C-reactive protein ( CRP ) levels may be an indicator of disease severity.
Elevated cystic MD , plurifocal medial apoptosis , and increased metalloproteinase-9 amount characterize it.
Elevated depressive symptoms ( DS ) are associated with incident mild cognitive impairment and probable dementia in postmenopausal women.
Elevated depressive symptoms were associated with slower gait speed.
Elevated depressive symptoms were categorized using the Center for Epidemiologic Studies Depression scale ( cut-score≥20 ) .
Elevated EM T cells were also positively associated with total cholesterol ( B = @number@ p < @number@ ) after applying similar adjustments.
Elevated erythrocyte membrane carbonyl levels found with increasing age in this study may be viewed as a biomarker for aging.
Elevated follicle-stimulating hormone ( FSH ) activity is proposed to directly cause bone loss independent of estradiol deficiency in aging women.
Elevated fruits and vegetables consumption has been associated with lower diabetes incidence.
Elevated glucocorticoid ( GC ) levels putatively damage specific brain regions , which in turn may accelerate cognitive ageing.
Elevated Hcy was found in @percent@ of male adults and @percent@ of female adults.
Elevated hippocampal and neocortical 11β-HSD1 is observed with ageing and causes cognitive decline ; its deficiency prevents the emergence of cognitive defects with age.
Elevated inflammation is common in obesity and associated with impaired cognition.
Elevated inflammation ( measured as serum hs-CRP ) does not explain this relationship.
Elevated inflammation , measured by cellularity , persists in virologically well-controlled HIV + individuals.
Elevated IOP characterizes glaucoma and arises from impaired aqueous humor ( AH ) outflow.
Elevated lactate dehydrogenase release upon sodium dodecyl sulphate challenge was reversed by the application of T. arjuna bark extract.
Elevated level of fluoride ( F ( - ) ) in drinking water is a well-recognized risk factor of dental fluorosis ( DF ) .
Elevated levels ( > 3.0mmol / l ) of hs-CRP were observed in ≤6h and ≥10h sleep.
Elevated levels of 8-isoprostane in IL-1β ± IFN-γ-activated human astrocytes indicate downstream lipid peroxidation.
Elevated levels of fapyguanine and fapyadenine in mitochondrial DNA suggest a hypoxic environment early in the progression of AD and in DC subjects.
Elevated levels of inflammatory chemokines commonly occur with aging but the mechanism underlying this age-associated change is not fully understood.
Elevated levels of Mdm2 in precancerous mice increased both the numerical and the structural chromosomal abnormalities observed.
Elevated levels of p25 relative to p35 cause dysregulation of Cdk5 activity leading to neuroinflammation and neurodegeneration.
Elevated MCP-1 levels that originated from MSC attract transendothelial migration of mononuclear leukocytes from blood to the tissue.
Elevated mean diffusivity and decreased fractional anisotropy are consistently found in prodromal AD , and even in cognitively normal elderly who progress to MCI.
Elevated methylation of the HPV16 L1 and L2 open reading frames , in particular , is associated with CIN2 , CIN3 and invasive cancer.
Elevated oxidative damage is involved in the pathophysiology of most age-dependent diseases and markers of oxidative damage often increase with age in many organisms.
Elevated oxidative stress levels may be one mechanism contributing to poor health outcomes.
Elevated percentage leg fat mass ( LgFM ) was protective against MetS among African-American men.
Elevated plasma homocysteine ( hcy ) levels , also known as hyperhomocysteinemia ( hhcy ) , have been associated with cognitive impairment and neurodegenerative disorders.
Elevated plasma L5 levels may be a novel etiology of adipose tissue inflammation in patients with MetS.
Elevated plasma Lp ( a ) levels are a significant and independent predictor of CHD risk in men.
Elevated PP in children with T1DM may contribute to the high risk for early development of atherosclerosis.
Elevated proteasome activity extends lifespan in model organisms such as yeast , worms and flies.
Elevated rDNA content was observed in DLB.
Elevated recruitment of CD115 + myeloid cells but not mature macrophages was observed in nerve ganglia , also in an age-dependent manner.
Elevated risk of death from any cause and stroke associated with high body mass index ( BMI ) values decline with aging.
Elevated risk of liver-related death in older adults may be addressed through antiviral therapy for hepatitis C virus infection.
Elevated ROS concentrations are associated with aging , inflammatory and degenerative diseases.
Elevated saturated fatty acids could have negative effects on age-related cognitive decline and mild cognitive impairment ( MCI ) .
Elevated serum cholesterol concentrations in mid-life increase risk for Alzheimer's disease ( AD ) in later life.
Elevated serum FGF21 levels were also a significant independent risk factor of carotid IMT on multiple stepwise regression analysis ( P = 0.01 ) .
Elevated serum triglycerides ( TRGs ) are associated with an increased risk for sensory neuropathy in diabetes mellitus.
Elevated sympathetic activity might be beneficial in relieving RLS symptoms , also causing increases in TOS.
Elevated systolic blood pressure is mainly caused by arterial stiffening , resulting from age-related vascular changes.
Elevated thyrotropin concentration was associated with longevity.
Elevated total cholesterol in midlife has been associated with increased risk of dementia in later life.
Elevated TXNRD activity in long-lived species reflected increases in the mitochondrial form , TXNRD2 , rather than the cytosolic forms TXNRD1 and TXNRD3.
Elevated UFC / Cr level and elevated UFC / Cr variability were related to a @number@.31- and @number@.38-times increase in AD risk , respectively.
Elevation of amyloid β-peptide ( Aβ ) is critically associated with Alzheimer disease ( AD ) pathogenesis.
Elevation of combined metabolic syndrome indicators ( b = @number@ p = @number@ ) conferred additional risk ( odds ratio @number@ ) .
Elevation of opening angle from 50° to 90° leads to increase of intimal compressive component compensating up to @percent@ of the pressure-induced tensile stress.
Elevation of the HP product UDP-N-acetylglucosamine in the nematode Caenorhabditis elegans results in resistance towards toxic aggregation-prone proteins , and extended lifespan.
Eleven age-associated differentially methylated regions ( DMRs ) passed Bonferroni correction ( P-value < @number@ × 10 ( @number@ ) ) .
Eleven blood samples were collected per patient.
Eleven categories of behaviors were identified across three domains : emotional , physical , and determination.
Eleven categories of food consumption were related to pure-tone averages of low-mid frequency hearing , and high frequency hearing.
Eleven community occupational therapists working with seniors having disabilities were recruited in six community health settings in Québec , Canada.
Eleven consecutive autopsy cases diagnosed with BPD were analyzed.
Eleven datasets emanating from nine published studies describing @number@ residents met all meta-analysis inclusion criteria and were analyzed using random effects models.
Eleven fetal specimens of 14-27 weeks GA were scanned by @number@.0T MRI.
Eleven geographically distant physicians evaluated the SQA test , taking the pretest and posttest within two weeks.
Eleven healthy young and @number@ healthy elderly individuals performed the sit-to-stand with their feet further away and closer to the chair.
Eleven human observational epidemiological studies examined dietary intakes of lignans in relation to cardiovascular disease risk.
Eleven key lessons learned are outlined.
Eleven monozygotic twin pairs ( age @number@ ± @number@ years ) discordant for HRT were studied.
Eleven motor performances were summarized into a previously described global motor score.
Eleven MRI identified lesions were not of ischemic nature and most commonly enlarged or atypically shaped perivascular spaces.
Eleven MWC users with spinal cord injury were assessed before and after training with a service dog and @number@ mo later.
Eleven of @number@ healthy young-adult subjects ( age 22-30 ) reached to grasp or touch the rail in response to the balance perturbation.
Eleven of the @number@ incident amyloid-positive subjects had abnormal hippocampal volume , FDG-PET , or both at baseline.
Eleven of these regions represent novel candidate regions for ALS risk.
Eleven participants aged @number@ to @number@ completed in-depth personal interviews.
Eleven participants were tested to evaluate BA and PTA stiffness.
Eleven patients were lost to followup , and one patient died of unrelated causes.
Eleven percent of Maori and @percent@ of non-Maori smoked ; @percent@ Maori and @percent@ non-Maori had alcohol on at least @number@ occasions per week.
Eleven randomized controlled trials have been found.
Eleven studies met our selection criteria.
Eleven studies were included.
Eleven subjects classified their under-eye bags as milder at the end of the trial compared to the first visit.
Eleven subjects would recommend the treatment to family and friends.
Eleven thousand eight hundred seventeen 6-month life-space change scores were calculated over @number@ years of follow-up.
Eleven years after disease onset his condition continues gradually and slowly to deteriorate.
Elicitations have successfully led to appreciable enhancements in the production of these major ginsenosides.
Eliciting surrogates ' perspectives is critical to ACP.
Eligibility criteria for disability benefits may influence the therapy motivation of rehabilitation clients.
ELIGIBILITY CRITERIA : Healthy adults , aged ≥65 years , with no specific disorders were included.
ELIGIBILITY CRITERIA : Systematic reviews ( SRs ) that included at least one comparative study evaluating any non-pharmacological intervention , to treat BPSD.
Eligibility criteria were established and applied by two investigators to include suitable studies.
Eligible participants were identified by means of a simple five-item screening tool.
Eligible patients were females aged @number@ or over and @number@ or younger with cellulite with documented cellulite 1°-4° according to the Nürnberger score.
Eligible pregnant women underwent a standard @number@ g oral glucose tolerance test between @number@ and @number@ weeks ' gestation.
Eligible publications described the development or application of QIs to assess the quality of community care for older people.
Eligible references included prospective studies in which structural neuroimaging assessments were performed in MDD samples.
Eligible studies included participants aged ≥65 years with hypertension.
Eligible studies were identified and data regarding study characteristics and outcome measures was extracted.
Eligible studies were identified from Medline and PsycINFO.
Eligible subjects who had blood measurements of vitamin B12 and red cell folate taken within six months of cognitive testing were included.
Eligible subjects will be requested participation through newspaper advertisements and direct contact at the shops.
Eligible women watched a video depicting the behavior of interest before completing a Web-based questionnaire.
Elimination half-life was clearly age-dependent for FVIII while only a very weak trend could be seen for rFIX.
Elimination of mild lines at repose was defined as change from mild to none on the Facial Wrinkle Scale.
Elimination of oxidized proteins is important to cells as accumulation of damaged proteins causes cellular dysfunction , disease , and aging.
Elimination of this source of variability will facilitate replication and interpretation of tDCS findings.
Elimination of TIC-associated macrophages ( TICAMs ) abolishes tumorigenesis in a manner dependent on the immune system.
ELISAs quantified IL-4 expression and Aβ levels.
ELISAs were performed to measure concentrations of thrombomodulin and syndecan-1 as biomarkers of endothelial cell damage and glycocalyx shedding respectively.
ELISA was also performed for validation.
ELISA was performed on supernatants from uninfected and Cpn-infected THP1 monocytes followed by statistical analysis with ANOVA.
Ellagitannins are extracted from oak wood during wine aging in oak barrels.
Elucidating the function of these SNPs is critical to identify the underlying pathways and , potentially , novel therapeutic agents.
Elucidating the molecular mechanisms of brain aging remains a significant challenge for biogerontologists.
Elucidation of such genetic bases may provide avenues for intervening in the aging process.
Elucidation of the dynamics of cancer initiation is of importance for an understanding of tumor evolution and cancer incidence data.
Elucidation of the mechanisms by which BNIP3 and NIX regulate cell death , autophagy , and mitochondrial clearance may lead to treatments for these conditions.
Elucidation of the pathomechanism of sIBM is the most important to therapy.
Elucidation of this novel mechanism provides a rationale for future pharmacotherapy in certain vascular diseases.
Emails contained a reminder program on the need for adherence with a healthy lifestyle based upon current guidelines.
EMA is a valid method for assessing smoking behavior in real-time and real-world settings.
EMBASE , MEDLINE , PsychInfo , CINAHL , Cochrane , and Ageline were searched covering all studies published from @date@ to @date@ .
Embedded in the NHIS is a policy to exempt poor and vulnerable groups from premiums and user fees.
Emblic leafflower may be a potential raw material for natural food preservatives.
Embryo donation and adoption are other alternatives that should be considered.
Embryo implantation is the crucial step for a successful pregnancy.
Embryonic development is critical for the final functionality and maintenance of the adult brain.
Embryonic stem cells could be an ideal source for transplantation , but ethical concerns restrict their development for cell therapy.
Embryonic stem cells ( ESCs ) are fast proliferating cells capable of differentiating into all somatic cell types.
Embryonic stem cells ( ESCs ) have remarkable properties of pluripotency and self-renewal , along with the retention of chromosomal integrity.
Embryo quality was assessed for embryo cell number , embryo fragmentation , and embryo symmetry.
Embryos derived from postovulatory-aged oocytes are prone to undergo apoptosis due to the decreased Bcl-2 expression.
Embryotoxicity of both intra and extracellular extracts were also tested on a local sea urchin species.
EM diagnostic criteria were based on the International Classification of Headache Disorders.
Emergence of comorbidities , particularly cardiovascular disease ( CVD ) has become a leading concern for patients living with the infection.
Emergence of new oral anticoagulants ( dabigatran , rivaroxaban , apixaban ) , which appear to be much more convenient , is promising.
Emergency care providers should be cognizant of prevalent geriatric syndromes including delirium and standing level falls to minimize fracture-related morbidity.
Emergency cholecystectomy was tolerable for patients with acute cholecystitis while continuing APT.
Emergency department visits and discharges from an overnight hospital stay in a 90-day period did not vary across residents by community bed size.
Emergency medical services ( EMS ) received an increasing number of calls for patients aged @number@ and older.
Emergency medicine ( EM ) residents should develop expertise and efficiency in geriatric care.
Emergency providers play a significant role in the management of patients with acute heart failure ( AHF ) .
Emergent evidence suggests that the long-term healthy lifestyle of master athletes may attenuate aging.
Emergent in the analyses was the variety of ways in which they experienced role ambiguity as ex-wife caregivers.
Emergent themes informed the theoretical model.
Emergent themes were identified and confirmed.
Emergent themes were identified from the transcripts and were compared within and across transcripts to develop more abstract concepts.
Emerging adulthood is a transitional period which has been examined in relatively few studies in Southern European countries.
Emerging data suggest that progressive aging significantly affects frequencies , subset distribution and functional competence of regulatory T cells ( Tregs ) .
Emerging evidence demonstrates that the NF-kappaB system is activated during aging.
Emerging evidence demonstrates the value of frailty as a predictor of adverse outcomes in older persons.
Emerging evidence from fMRI studies suggests that humor processing is a specific social cognitive-affective human function that comprises two stages.
Emerging evidence has linked this organelle to aging and finding mitochondrial dysfunction in accelerated aging disorders thereby strengthens the mitochondrial theory of aging.
Emerging evidence has suggested a potential impact of gut microbiota on the pathophysiology of heart failure ( HF ) .
Emerging evidence implicates a spectrum of epigenetic processes in the pathophysiology of stroke.
Emerging evidence indicates that androgens may provide a protective effect against the development and / or progression of atherosclerosis in men.
Emerging evidence indicates that autophagy dysfunction is closely related to various human diseases including cancer , aging , myopathies and neurodegenerative disorders.
Emerging evidence indicates that certain microRNAs ( miRNAs ) play important roles in epileptogenesis.
Emerging evidence indicates that several proteins associated with early-onset familial PD play critical roles in mediating the neuronal death.
Emerging evidence indicates that stimulus novelty is affectively potent and reliably engages the amygdala and other portions of the affective workspace in the brain.
Emerging evidence in the past @number@ years has suggested that sleep apnea is a novel risk factor in the development of diabetes.
Emerging evidence now suggests that epigenetics may also be involved , which provides potential new therapeutic targets.
Emerging evidence now suggests that the timing and dosage of creatine supplementation may be important factors for aging muscle accretion.
Emerging evidences show that autophagy , as a major cellular adaptive degradation mechanism , is involved in tumorigenesis , cell aging , inflammation and neurodegeneration.
Emerging evidence suggests that basal autophagy is necessary for the removal of misfolded , aggregated proteins and damaged cellular organelles through lysosomal mediated degradation.
Emerging evidence suggests that cellular senescence also acts as a potent tumor suppression mechanism that prevents the oncogenic transformation of primary human cells.
Emerging evidence suggests that disturbances of sleep in older people may co-occur with underlying neurobiological changes.
Emerging evidence suggests that early surgery ( < 24 h ) minimizes complications secondary to immobilization , including orthostatic pneumonia and venous thromboembolism.
Emerging evidence suggests that energy metabolism is an important regulator of neural stem cell function.
Emerging evidence suggests that excessive NO production can contribute to these pathological processes , specifically by S-nitrosylation of specific target proteins.
Emerging evidence suggests that multimorbidity among HIV-infected persons results in functional decline , reduced quality of life , and increased mortality.
Emerging evidence suggests that orthotics , specific shoe types and footwear interventions may provide an effective nonsurgical intervention in rheumatic diseases.
Emerging evidence suggests that oxidative / nitrosative stress , as occurs during aging , contributes to the pathogenesis of Parkinson's disease ( PD ) .
Emerging evidence suggests that pro-inflammatory cytokines interleukin-1 ( IL-1 ) and IL-18 show an age-dependent regulation implicating inflammasome-mediated caspase-1 activation in the aging process.
Emerging evidence suggests that these different types of external interference exert different effects on behavior and may be mediated by distinct neural mechanisms.
Emerging evidence suggests that VSMC behaviour is modified by age , which in turn may affect disease outcome in the elderly.
Emerging evidence supports glycolysis as the major metabolic pathway to meet ATP demand during osteoblast differentiation.
Emerging evidence to support the previously assumed notion that ceramide acts in a strictly structure-specific manner are also included.
Emerging findings elucidate cellular and molecular mechanisms by which exercise and energy intake modify the plasticity of neural circuits in ways that affect brain health.
Emerging findings highlight the complexity and heterogeneity of different compartments in the niche , as well as the presence of local signaling microdomains.
Emerging findings suggest that both AD and chronic adverse stress affect hippocampal neural networks in a similar fashion.
Emerging from progress made in many nonhuman models , current research has expanded to formal , controlled human studies of CR.
Emerging insights into the mechanistic roles of adiponectin and AD highlight the potential therapeutic effects for AD through insulin signaling.
Emerging knowledge of the actions of calcium upstream and downstream of Aβ provides opportunities to develop novel preventative and therapeutic interventions for AD.
Emerging research suggests that some human diseases are associated with global defects in @number@ PRF.
Emerging studies link vascular risk factors and cerebrovascular health to the prevalence and rates of progression in Alzheimer's disease ( AD ) .
Emerging theories suggest that a group of factors induce optic nerve injury in innately susceptible aging optic nerves.
Emerging thought suggests that pro-inflammatory signaling and oxidative stress may contribute to sarcopenia.
Emerging , young , and middle-aged adults were less optimistic about their creativity development into old age.
Emery-Dreifuss muscular dystrophy and Hutchinson-Gildford Progery Syndrome are two examples of laminopathies.
Emetine also induced cell death in other primary refractory lymphoma cells with MYC rearrangement.
Emetine induced the death of these cells with a half maximal inhibitory concentration of @number@ nM and @number@ nM , respectively.
EMG ( MF ) of the elderly and the young increased monotonically from @percent@ to @percent@ @number@ RM testing conditions.
EMG of the flexor digitorum superficialis and handgrip force were also recorded.
EMG signals of @number@ postural muscles were recorded and analyzed.
Emissions from a log wood burner were diluted and injected into a smog chamber for photochemical aging.
emission tomography was performed under the suspicion of metastatic renal tumor and malignant lymphoma.
Emodin-8-O- ( @number@'-O-malonyl ) -glucoside , a unique anthraquinone glycoside known to be completely eliminated in the conversion process of Heshouwu was isolated.
Emotional and informational support did not moderate the depression to walking relationship.
Emotional aspects of religiousness such as facets of the perceived relationship with God can be crucial in this connection.
Emotional distress was the strongest predictor of pain interference for children , whereas pain intensity was the strongest predictor for both adult groups.
Emotional disturbances in SIVD are not well understood.
Emotional experiences refer to repartnering being a replacement for couplehood but not for parenthood / grandparenthood.
Emotional labor strategy , in turn , affected well-being.
Emotional responsiveness was related to the severity of behavioral abnormalities as measured by the Frontal Behavioral Inventory and associated with atrophy of the left putamen.
Emotional support was more nuanced and complex for these widows.
Emotion often enhances memory for stimulus features , but the relationship between emotion and the binding of features in memory is unclear.
Emotion regulation abilities moderated threat effects in young adults but not in older adults.
Emotion regulation difficulties mediated the relation between betrayal trauma history and negative communication.
Emotion regulation-relevant attention may thus differ depending on whether stimuli are freely chosen or not.
Empathic accuracy is the ability to correctly identify others ' thoughts and feelings.
Empathy is an important psychological capacity that involves the ability to recognize and share emotions with others.
Emphasis is given to similarities in molecular causes and consequences of nucleolar stress in other neurodegenerative disorders.
Emphasis is placed on studies of memory cells in macaques infected with SIV because many studies are available.
Emphasis is placed on the clinical presentation and management of septic facet joints and psoas muscle abscesses associated with lumbar spondylodiscitis.
Emphasis is placed on young adults to provide more informative descriptions of epiphyseal changes associated with the final phases of skeletal maturation before degeneration commences.
Emphasis on studying the skin's architecture and biomechanics in the context of restoring skin movement and function is often ignored.
Empirical data from genomic sequencing along with prospects for combining strands of theory hold hope for future progress.
Empirical estimates of window width differ widely , however , ranging from @number@ to @number@ ms depending on context and experimental paradigm.
Empirical evidence indicates that impaired mitochondrial energy metabolism is the defining characteristic of almost all cases of Alzheimer's disease ( AD ) .
Empirical evidence of programmed lifespan limitations continued to accumulate.
Empirical evidence of the limits of the rationalistic models are presented next.
Empirical evidence on positive emotions is scarce and mixed.
Empirical studies to date clearly identify navigation as an aspect of cognitive function that is vulnerable to the aging process.
Empirical studies to investigate the role of epigenetics in trans-generational gene regulation and disease require appropriate model organisms.
Empiric antimicrobial therapy should be avoided when possible.
Employees must receive education to prepare for all aspects of their work , and management must account for employees ' situation when planning the care.
Employers are implementing workplace health promotion and wellness programs to improve health among workers and reduce presenteeism.
Employers have to deal with the ageing of their employees and adjust human resource management to maintain their competitiveness.
Employing adenomatous polyposis coli gene mutant mice , we recently reported on the role of Vash2 in the spontaneous formation of intestinal tumors.
Employing discrete-time multilevel models , we explored the effect of social support on the survival of elderly people in China.
Empowerment is the basic idea that patient support is not widely known by pharmacists but the certified diabetes educator ( CDE ) .
EMR search algorithms significantly outperformed International Classification of Diseases codes.
EMS providers must be aware of the various challenges of transporting the geriatric population.
Enablers to accessing care included carer knowledge and workers actively involving carers in planning.
Enabling communication between motor neurons and the muscle fibers they innervate is a specialized synapse known as the neuromuscular junction.
Enabling elderly people to age within First Nations communities will require multi-level and multi-sectoral system changes.
En bloc resections of the columella were harvested.
Encoding processes , on the other hand , are critically dependent on the to-be-remembered material , and seem to necessitate material-specific neural substrates.
Encoding was followed by a recognition task.
Encompassing a growing multidisciplinary domain , the emergent era of \ "regenerative rehabilitation \ " brings radical innovations at the forefront of healthcare blueprints.
Encouraged by this trend , gambling industries have modified their activities to attract and market to this group.
Encouraging appropriate and aggressive treatment for both HF and COPD should be recommended to improve quality of life and mortality in HF patients with COPD.
Encouraging DON use of complexity leadership approaches has the potential to improve a broad swath of quality outcomes.
Encouraging residents to engage in more physical activity could deliver benefits in terms of physical and psychological health , and quality of life.
Encouraging results from animal studies indicate that physical activity may counteract the biological processes inducing AV degeneration.
Endoanal ultrasonography performed @number@ year following surgery was considered normal in both of the studied groups.
Endocannabinoid signalling has been found to be altered in many neurodegenerative disorders.
Endocrine disruption is a concept and principle whose origins can be traced to the beginnings of the environmental movement in the 1960s.
Endocrine function undergoes major changes during aging , as well.
Endocrine hormone levels and @number@ , 25-dihydroxy-vitamin D3 levels were comparable between lead exposure and control group.
Endocrine-immune system interactions are the basis for predominance of autoimmune diseases in women with differences between the fertile and the postmenopausal periods.
Endocrine modifications may accompany the progression of ND , due to the intimate connections between central nervous and endocrine systems.
Endocrine responses in OM were similar before and after training.
End of life is defined by a limited lifespan or advanced disability.
End-of-life pharmacotherapy is sometimes perceived to be complex and challenging , probably unnecessarily.
End-of-life service providers continue to seek improved instruments for individuals to convey their last wishes.
End of study plasma homocysteine , folate and B12 concentrations were measured.
Endogenous and maximal SR Ca ( 2 + ) content were significantly smaller in both type I and type II fibres in Old subjects.
Endogenous COX-2 expression in wild-type mice is a late event in the development of hepatocellular carcinoma.
Endogenous heat shock proteins ( HSP ) are decreased in disease states associated with insulin resistance and aging.
Endogenously formed dicarbonyl compounds can react with proteins to form advanced glycation endproducts ( AGEs ) .
Endogenously-produced melatonin , a powerful free radical scavenger , declines with age and its loss contributes to degenerative conditions of aging.
Endogenously produced ROS also stimulated HBx expression.
Endogenous p53 isoforms have been identified in cancers ; however , the function of these isoforms remains unclear.
Endogenous physiological mechanisms are able to neutralize RMS to some extent , thereby limiting damage.
Endogenous ROS from wild and HBx transgenic mice and HepG2-Mock and HBx cells were assayed by FACScalibur.
Endogenous sex steroid levels were unassociated with cognitive composites , but sex hormone binding globulin was positively associated with verbal memory.
Endogenous testosterone is known to be protective against metabolic syndrome ( MetS ) in men.
Endoglin ( ENG ) is a causative gene of type @number@ hereditary hemorrhagic telangiectasia ( HHT1 ) .
Endometrial cancer patients diagnosed at age ≥15 years in Germany during 1997-2011 and in Sweden nationwide during 1997-2012 were selected.
Endonuclease Dicer controls miRNA and dsRNA processing , however the role of Dicer in circadian regulation is not known.
Endophenotypes are the various molecular domains that exist at intermediate levels of organization between the genotype and phenotype.
Endoplasmic reticulum ( ER ) stress results from an imbalance between the abundance of synthesized proteins and the folding capacity of the ER.
Endoscopic hemostasis was performed in @percent@ of all cases with efficacy ranging from @number@ to @percent@.
Endoscopic method of rejuvenating the brow-forehead complex has evolved into the procedure of choice for many aesthetic surgeons.
Endoscopic retreatment can be an option to control ulcer rebleeding and reduce complications.
Endoscopic therapy reduces the need for emergency surgery in bleeding peptic ulcers.
Endoscopists blinded to patients fasting status carried out the endoscopies.
Endoscopy is still helped in the correct indication for surgery in high-risk surgical patients.
Endoscopy-negative patients were further blindly evaluated by both CT-enteroclysis and VCE.
Endostatin ( ENDS ) was the highest in aged ADSC and was also down-regulated by hypoxia.
Endostatin positive blood vessels were also detected in skin samples of all ages.
Endothelial cell count decreases by @number@ cells / mm ( @number@ ) per year ( p < @number@ ) .
Endothelial cell ( EC ) dysfunction has been reported in cystic fibrosis ( CF ) patients.
Endothelial cell inflammation and circulating biomarkers of inflammation and antioxidant capacity were associated with exercise performance and microcirculation of the ischemic calf musculature during exercise.
Endothelial cells , astrocytes , and pericytes have important roles in preserving vasculature integrity.
Endothelial cells ( EC ) respond to injury by releasing numerous factors , including von Willebrand factor ( VWF ) .
Endothelial cells ( ECs ) provide angiocrine factors orchestrating tumor progression.
Endothelial cells in neovascular membranes were invariably CD34 positive.
Endothelial cells represent major effectors in inflammation and angiogenesis , processes that drive a multitude of pathological states such as atherosclerosis and cancer.
Endothelial cell viability was monitored by impedance measurement in real-time.
Endothelial dysfunction accompanied by increased oxidative stress and inflammation with aging may predispose older arteries to greater ischemia-reperfusion ( I / R ) injury.
Endothelial dysfunction and arterial stiffness are early predictors of CVD.
Endothelial dysfunction and impaired autophagic activity have a crucial role in aging-related diseases such as cardiovascular dysfunction and atherosclerosis.
Endothelial dysfunction and inflammatory cells adhesion to endothelium have been regarded as important and early factors in the pathogenesis of vascular complications in diabetic patients.
Endothelial dysfunction and low-grade inflammation lead to negative remodeling in hypertension.
Endothelial dysfunction caused by endothelial cells senescence and chronic inflammation is tightly linked to the development of cardiovascular diseases.
Endothelial dysfunction develops with age and increases the risk of age-associated vascular disorders.
Endothelial dysfunction in essential hypertension is an independent predictor for future cardiovascular events.
Endothelial dysfunction , in part resulting from excessive production of reactive oxygen species , is an important mechanism of cerebrovascular damage.
Endothelial dysfunction , lipoprotein alterations , inflammation , and platelet activation are the mechanisms by which remodeling occurs.
Endothelial function ( brachial flow mediated dilation ) , echocardiography , physical performance , and quality of life were assessed , as well.
Endothelial function was assessed by flow-mediated dilation ( FMD ) of the brachial artery by ultrasound.
Endothelial function was assessed via brachial artery ultrasound and arterial stiffness via arterial tonometry.
Endothelial NO generation is highly regulated by mechanical , humoral , and metabolic factors.
Endothelial polymegathism index and pleomorphism index do not change with age ( p = @number@ and p = @number@ respectively ) .
Endothelial response to the vasoactive substances did not change , nor did arterial stiffness in any of the four groups.
Endothelial senescence has been suggested to promote endothelial dysfunction in age-related vascular disorders.
Endothelial tube formation promoted by HG-HRMC-CM was disrupted in the presence of PCE.
Endothelial vasoactive factors regulate vascular homeostasis under physiological conditions and maintain basal vascular tone.
Endothelin-1 ( ET-1 ) is a short chained peptide primarily of endothelial origin.
Endothelin-1 ( ET-1 ) is the most abundant and important endothelin produced by vascular cells.
Endothelin-1 ( ET-1 ) plays a major role in regulating myocardial fibrosis in several pathological conditions , such as hypertension and diabetes.
Endothelin and renin-angiotensin systems seem to be most prominent targets for therapeutic interventions in the view of valvular pathogenesis.
Endothelin ( ET ) -1 plays an important pathophysiological role in several vascular diseases including hypertension and atherosclerosis.
Endothelin receptor antagonists were considered to be used for the treatment of some diseases like hypertension , diabetes and chronic kidney disease.
Endothelium-dependent contractions are also observed in various models of hypertension , aging and diabetes.
Endothelium-dependent contractions contribute to endothelial dysfunction in various animal models of aging , diabetes and cardiovascular diseases.
Endothelium-dependent vasodilatation is reduced with advancing age in humans , as evidenced by blunted vasodilator responsiveness to acetylcholine ( ACh ) .
Endothelium-dependent vasodilation ( pressurized myograph ) was assessed by acetylcholine , repeated under the nitric oxide synthase inhibitor N-nitro-l-arginine methylester or the antioxidant tempol.
Endovascular interventions should be favored over surgical procedures as they are associated with fewer complications.
Endovascular treatment of acute mesenteric ischemia was successful ( n = @number@ ) and no patient required open surgical revascularization acutely or during follow-up.
Endoventricular allogeneic MSC injection has been associated with reduced adverse cardiac events in a phase-II trial in patients with chronic heart failure.
End point of interest were postoperative complications , 90-day mortality , length of hospital stay and readmission within @number@ days.
Endpoints committee confirmed mortality.
End points for skin moisture , skin elasticity , wrinkle reduction , skin compactness and skin appearance were measured.
End points were all-cause mortality and cardiac death after a median follow-up of @number@ years.
Endpoints were calculated by quintile of Mg and adjusted for relevant confounders.
Endpoints were composite events ( death / HF-related re-hospitalization ) .
End-stage organ failure is a devastating problem with limited therapeutic options.
End-stage renal disease ( ESRD ) patients have a severely immunologically aged T cell compartment but also a high prevalence of CMV infection.
End-tidal breath CO levels were measured and used to calculate erythrocyte lifespan.
Endtidal sevoflurane concentration , occurrence of laryngospasm and blood pressure at laryngeal mask airway placement were also recorded.
Endurance and strength also improved ( p < @number@ and p < @number@ ) .
Endurance , cognitive dual-tasking , and vision-related QOL may have improved more for Tango than FallProof.
Endurance exercise counters these diseases by inducing beneficial adaptations whose molecular mechanisms remain unclear.
Endurance of the low back musculature was assessed using modified Biering-Sørensen test of Static Muscular Endurance.
Endurance time and perceived muscle fatigue ( Borg CR-10 scale ) were used as fatigue criteria.
Endurance training increases peak fat oxidation ( PFO ) during exercise , but whether this is independent of changes in body weight is not known.
Energy and macronutrient intakes were also analyzed as potential predictors of depression.
Energy and macronutrient intake was calculated using the @number@ Dutch food composition database.
Energy and protein intakes were standardized and no resistance training was allowed.
Energy and protein intake were determined from medical records on a typical day and dichotomized by meeting the estimated average requirement.
Energy assurance recognizes that power loss / disruption cannot be eradicated completely , but jurisdictions can mitigate the impact of power loss through effective planning.
Energy demands associated with walking suggest that mitochondrial bioenergetics may play a role in gait speed.
Energy-dense , yet nutritionally poor food is a high-risk factor for mental health disorders.
Energy expenditure ( EE ) was examined by doubly labeled water ( DLW ; TEE ) and respiratory chamber ( @number@ h EE ) .
Energy intake and physical activity were also estimated by self-report over ≥6 consecutive d in each DLW period.
Energy intake from sweets was @percent@ higher than recommended.
Energy intake under-reporting ( UR ) is a concern in nutritional epidemiological studies , as it may distort the relationships between dietary habits and health.
Energy intake was not significantly associated with REV-ERB-ALPHA1 rs2314339.
Energy intake was suppressed by the protein compared with control ( P = @number@ ) .
Energy-related emergencies , such as power outages or interruptions to other energy supplies , can arise from a number of factors.
Energy restriction , though , is associated with health improvements and increased longevity.
Enforced expression of Klotho could significantly induce cell apoptosis and inhibit tumor growth in DLBCL.
Engaged in mental work and slow transit constipation were main related factors for yang deficiency syndrome ( P < @number@
Engagement in activities of daily living was the crucial predictor for falls during the first to second postoperative years among older hip fracture patients.
Engagement in cognitive activities was inversely associated with the onset of cognitive impairment at 5-year follow-up but was no longer significant at 10-year follow-up.
Engagement in formal and informal activities was not significantly associated with health at follow-up.
Engagement in @number@ leisure and social activities was collected at baseline and at the 10-year follow-up visit for @number@ subjects.
Engagement in PA , MA and SA was obtained from self-report questionnaires.
Engagement in physical activity in late life may have cognitive health benefits.
Engagement with local stakeholders is needed to harmonize fundamentally different ways of understanding the human body and community identity with the aims of contemporary biomedicine.
Engaging firearm advocates when developing materials may enhance the acceptability of prevention activities.
Engaging frontline staff , including personal support workers , was stated as an essential component of all recommendations.
Engaging in exercise using equipment and body weight was associated with higher scores of general health.
Engaging in mild to moderate exercise increased the chances of reporting poor health by @number@ times.
Engaging in organized social activity was associated with fewer depressive symptoms in both groups.
Engaging in physical activity , formal exercise , and specific recreational activities had a favorable effect on short-term cognitive decline.
Engaging in sexual behavior was generally associated with younger age , greater social support , healthier behaviors , and better physical and psychological health.
Engaging in suppression resulted in higher relationship satisfaction , particularly for women , whereas engaging in reappraisal reduced negative affect for middle-aged versus younger adults.
Engaging in volunteer work may be beneficial for increasing feelings of usefulness and indirectly improving depressive symptoms among older adults.
Engaging older adults in their health care decision making would cut down health care costs and prepare a health care system to be more sustainable.
Engaging older people at risk to share meal preparation and dining experiences may foster better outcomes.
English and German language peer-reviewed journal articles published between @number@ and @number@ were included.
English , Dutch , French and German-language articles reporting cross-sectional or longitudinal , intervention or observational studies of cancer treatment adherence were included.
English readers ( @number@ children , @number@ adults ) , and Arabic readers ( six children , five adults ) were recruited.
Engrafting the muscles of facial expression improves graft retention and therefore predictability and symmetry.
Enhanced ALP activity was reduced in presence of IGF1 receptor inhibitor : picropodophyllin.
Enhanced depth imaging spectral domain optical coherence tomography was applied for measurement of SFCT.
Enhanced echo intensity ( EI ) on ultrasonography images of skeletal muscle is believed to reflect muscle quality.
Enhanced eIF4E3 expression marginally suppresses eIF4E1-driven translation but exhibits a unique translatome that unveils a novel role for eIF4E3 in translation initiation.
Enhanced FOXO activity , at least in model organism contributes to extended lifespan and acts as a tumor suppressive mechanism.
Enhanced knowledge and healthy attitudes toward aging sexuality can help promote the perception that full sexual expression is part of the entire extent of adulthood.
Enhanced mTORC1 activity drives characteristic phenotypes of senescence , although the underlying mechanisms responsible for increased activity are not well understood.
Enhanced NO production increases the activities of the transcription factors p53 and nuclear factor κB ( NF-κB ) in several models of disease-associated inflammation.
Enhanced p16 ( INK4A ) expression was only related to a significantly shorter DFS.
Enhanced P3 and N1 amplitudes and a decreased P3 latency were observed in the higher physical activity group.
Enhanced recovery after surgery ( E.R.A.S. ) has been proven to be beneficial for patients.
Enhanced resistance to oxidative stress was associated primarily with compounds that target receptors for biogenic amines , such as dopamine or serotonin.
Enhanced study of the role of IIS pathway and epigenetic mechanisms that regulate aging may facilitate progressive prevention and treatment of human age-related diseases.
Enhanced tidal volume increment response to 6%CO ( @number@ ) was present at 16-20 , and 75-90 postnatal days , implying the trait's stability.
Enhanced understanding of modifiable risk factors may yield opportunities for prevention.
Enhancement of these features made UV passing best for capturing photodamage.
Enhancing behavioral activation and decreasing anxiety were not found to mediate improvements in functional disability.
Enhancing neighborhood cohesion may enhance elder self-neglect prevention and intervention.
Enhancing p53 function in the lens could contribute to the prevention of steroid- and radiation-induced posterior subcapsular cataracts.
Enhancing the functional properties of these cells may be important as they provide an antigen-specific defense against chronic infections.
Enhancing the mobility of geriatric patients through suitably tailored kinesitherapeutic methods during their hospital stay may mitigate the burden endured by FCs.
Enjoying taste should be one of the greatest pleasures in human life.
Enjoyment of life was assessed by questionnaire.
Enlarged ascending thoracic aorta and descending thoracic aorta were not significantly associated with CVD events.
Enlargement of this structure , together with certain morphological features , may indicate a predisposition to the formation of thrombi and subsequent cardioembolic stroke.
Enobosarm ( GTx-024 , S-22 ) is a recently developed SARM , developed by GTx , Inc.
Enriched terms include various functional categories related to glutathione and antioxidant activity , ion transport and metabolic processes.
Enriching for subjective memory complaints reduced sample sizes and numbers needed to enroll more than age enrichment , but increased the number needed to screen.
Enrichment analyses have identified several biological processes related to immune system responses and aging in the control group.
Enrichment analysis showed that the pathways overrepresented in the senile rats matched those of an exacerbated inflammatory environment , reinforcing our morphologic findings.
Enrichment for developmental and extracellular matrix maintenance pathways indicated possible reactivation of endochondral ossification.
Enrichment-pathway analyses revealed canonical pathways mainly involved in neuronal functions , for example , axonal guidance signaling.
Enrolled patients were divided into two study groups of patients affected by hyperparathyroidism with or without a concomitant thyroid disease.
Enrolled patients will be randomized to either CTA or ICA ( n = @number@ per group ) as the first test to define coronary anatomy.
Enrolled subjects were classified according to H. pylori infection status and intake of nonsteroidal anti-inflammatory drugs.
Enrolled subjects were taking no medications and had no disorders that altered bone metabolism.
Enrollment in the TTrials began @date@ ; the final participant completed treatment and assessment in @date@ .
Enrollment of twins and higher-order multiples of all ages and their family members started on @date@ .
Enrollment was higher among single parents ( OR = @number@ @percent@ CI = @number@ @number@ ) .
Enrollment will begin @date@ and continue for @number@ years.
Ensuring accommodations and accessibility will benefit patients with impaired mobility and clinical staff.
Ensuring adequate prevention and treatment strategies for osteoporosis is vitally important with our diabetic patients as the population ages.
Ensuring that practitioners are confident in their knowledge of direct payments , and have the communication skills to impart that knowledge , is essential.
Ensuring that these actions address the specific concerns of individuals with disabilities , such as physical accessibility and provider cultural competency , is essential.
( ENT1A ) , general Bacteroides ( GB3 ) , and human-associated Bacteroides ( HF183 ) in freshwater sediments was evaluated.
Enteral nutrition in dementia has traditionally been discouraged , although further understanding of physical , nutritional and quality of life outcomes are required.
Enteric glia were twice as abundant in mutant mice compared with those in control animals , while myenteric neuron number was normal.
Entering cognitive abilities to these models did not substantially attenuate effect sizes.
Enterovirus @number@ ( EV71 ) infection has become an important endemic disease in Southeast Asia and China.
Enthesopathies are frequently found in rheumatic inflammatory diseases , but can be observed also in absence of systemic inflammation.
Entorhinal tau was associated with frontal hypometabolism , but this dysfunction was not associated with memory loss.
Entry of sildenafil citrate in the mouse cochlea was confirmed by qRT-PCR analysis of a downstream target of the cGMP-PKG cascade.
E ( @number@ ) and tamoxifen did not influence cell proliferation , cell morphology , and β-galactosidase staining in chondrogenic cells.
E ( @number@ ) treatment did not affect the telomere-associated proteins TRF1 and TRF2.
E ( @number@ ) treatment increased pyruvate dehydrogenase kinase @number@ mRNA expression in myotubes from female donors.
Enumeration of SIRT3 and SIRT5 targets via advanced proteomic techniques promises to dramatically enhance insight into functions of these proteins.
Environ.
Environ Health Perspect 124 : 1715-1721 ; @url@
Environ Health Perspect 124 : 1744-1750 ; @url@
Environmental and genetic factors determine this asymmetry during brain development and modulate its interaction with brain disorders.
Environmental barriers and facilitators outdoors were self-reported.
Environmental barriers at entrances and in exterior surroundings were objectively registered ( Housing Enabler screening tool ) and divided into tertiles.
Environmental challenges such as a high fat diet during pregnancy can induce changes in offspring growth , metabolism and cardiovascular function.
Environmental conditions in early life can profoundly affect individual development and have consequences for reproductive success.
Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health.
Environmental context is widely recognized as a critical influence on older adults ' well-being.
Environmental exposures likely have an impact on this observation , but remain largely unidentified.
Environmental factors are key triggers in timing endocrine aging with implications for eventual disease.
Environmental , genetic , and accidental factors have influenced the human life span.
Environmental , genetic , and stochastic factors all affect longevity.
Environmental influences on AUD can have long-lasting effects , and the effects of preventive efforts may be enduring.
Environmental influences on the @number@ disorders were correlated in middle , but not in young adulthood.
Environmental lithium exposure and concurrent nutritional intake vary considerably in different regions.
Environmental measures at different spatial levels have seldom been compared.
Environmental mediators of these associations were also examined.
Environmental or social challenges can stimulate a cascade of coordinated physiological changes in stress response systems.
Environmental physical factors also play a role.
Environmental Risk Factors in Multiple Sclerosis ( the ' EnvIMS-Q' ) is a 6-page self-administered questionnaire for case control studies.
Environmental stimulation increases brain reserve.
Environmental toxins , especially heavy metals , may prove to be a previously neglected part of the puzzle.
Environmental variables , consultation characteristics , socio-demographic and health need characteristics were collected.
Environment influences seem to be largely transient.
Enzalutamide was generally well tolerated in chemotherapy-naïve men with metastatic CRPC.
Enzalutamide ( Xtandi ( ® ) ) is an androgen receptor inhibitor that blocks several steps in the androgen receptor signalling pathway.
Enzymatically raised palmitoylation levels restored the surface expression of the p.G257R variant γ2 subunit.
Enzymatic assay is the preferred technique.
Enzymatic crosslinks initially form via immature divalent crosslinking , and a portion of them convert into mature trivalent forms such as pyridinoline and pyrrole crosslinks.
Enzyme activity is reduced in neonates but the maturation of sufentanil clearance is not described.
Enzyme-linked immunosorbent assay confirmed a 2-fold increase in IFNα in APP / PS1 brains compared with control brains.
Enzyme-linked immunosorbent assays and chemotaxis assays were used to confirm proinflammatory chemokine secretion between depots.
Enzymes and antioxidants , which are one of the body's defenses , can prevent oxidative processes.
Enzymes metabolising dicarbonyls , glyoxalase @number@ and aldoketo reductases , provide an efficient and stress-response enzyme defence against dicarbonyl stress.
Enzymic assays showed that SHP-1 activity was upregulated in T cells of aged donors , in contrast to young subjects.
EOAD patients showed greater executive and linguistic deficits , while LOAD patients showed greater semantic memory impairment.
EOD is associated with greater disturbances in cortical thickness than LOD , even when duration of illness and other factors are controlled.
EO-FTD patients had lower memory and frontal / executive scores and more prominent frontal / behavioral symptoms than LO-FTD patients.
Eosinophils are almost absent in dermis independently on age.
Eosinophils are rarely observed in human dermis.
Eosinophils were increased in asthma , especially when associated with rhinitis.
EP67 , induced the release of the pro-inflammatory cytokines IL-6 , TNFα , and INFγ from splenic APCs obtained from both aged and young mice.
EPC-TA was reduced in PCAD patients , but was statistically significant only after adjustment for confounding factors ( @number@ Vs.
EphA2 oxidation interfered with ephrin A1-stimulated receptor auto-phosphorylation , activation of Src family kinases , and caveolin-1-mediated internalization of the receptor.
Epidemiological analyses reported that ARBs reduced the progression of Alzheimer's disease , and clinical studies suggested amelioration of cognitive loss following stroke and aging.
Epidemiological and cellular biological studies indicate the influence of impaired circadian biological rhythmicity on atherosclerosis.
Epidemiological and experimental studies indicate that early vascular dysfunction occurs in low-birth-weight subjects , especially preterm ( PT ) infants.
Epidemiological and pathological data suggest that DM contributes to mild cognitive impairment ( MCI ) and dementia.
Epidemiological data is strengthened by experimental evidence of aluminum exposure leading to excess inflammatory activity within the brain.
Epidemiological data testifies the increasing incidence of Alzheimer's disease ( AD ) and type @number@ diabetes mellitus ( T2DM ) .
Epidemiological evidence has shown an association between tea consumption and the prevention of bone loss in the elderly population.
Epidemiological evidence supports the hypothesis that modifiable lifestyle-related factors are associated with cognitive decline , opening new avenues for prevention.
Epidemiological findings suggest influences operating across the life course may be important.
Epidemiologically , studies need to move from association studies to develop ORT into appropriate screening and predictive tests.
Epidemiological , neuropathological , and functional neuroimaging evidence implicates global and regional disruptions in brain metabolism and energetics in the pathogenesis of cognitive impairment.
Epidemiological research , however , has provided evidence of specifically modifiable risk and protective factors.
Epidemiological research of telomeres investigates the role that these genetic structures have in disease risk and mortality in human populations.
Epidemiological studies have demonstrated that prevalence of hypogonadism in old males increases with every additional decade of life.
Epidemiological studies have indicated that estrogen therapy reduces the risk of developing AD in women.
Epidemiological studies have provided evidence of a protective role of healthy diets in the prevention of cardiovascular diseases.
Epidemiological studies have shown a relation between antioxidants and the prevention of several chronic diseases.
Epidemiological studies have shown that alcoholism is closely associated with impaired memory and judgment.
Epidemiological studies have shown that low vitamin D status results in impaired immune function and is associated with the prevalence of autoimmune and inflammatory conditions.
Epidemiological studies raise a possibility that the relationship of IGF-1 and perhaps also GH levels with human healthy aging and longevity may be biphasic.
Epidemiological studies show a close relationship between physical activity and cognition.
Epidemiological studies suggest a protective role of omega-3 poly-unsaturated fatty acids ( n-3 PUFA ) against Alzheimer's disease ( AD ) .
Epidemiological studies suggest that a delayed natural menopause confers longevity and decelerates the appearance of many of the debilitating morbidities associated with the menopause.
Epidemiological studies suggest that cytogenetic biomarkers such as micronuclei in peripheral blood lymphocytes may predict cancer risk because they indicate genomic instability in target tissues.
Epidemiological studies suggest that dysglycemia is a risk factor for cognitive impairment but the underlying pathophysiological mechanisms remain unclear.
Epidemiological studies suggest that plant polyphenol resveratrol ( REV ) is associated with reduced risk of cardiovascular diseases.
Epidemiologic data and outcomes were also analyzed between cohorts on admission , Day @number@ and Day @number@
Epidemiologic data suggest that people who develop neurodegenerative diseases of aging have a decreased risk of cancer.
Epidemiologic evidence indicates a trend toward association between severity of light exposure and AMD.
Epidemiologic studies have documented an increasing frequency of anaemia in individuals @number@ yrs and older.
Epidemiologic studies have documented the rising burden of DHF , and experimental data are revealing the unique mechanisms distinguishing it from systolic heart failure.
Epidemiologic studies show a higher incidence of malignant melanoma in persons with a history of sunburns during childhood and adolescence.
Epidemiologic studies suggest a diet high in vitamin K is associated with a lower risk of hip fractures in aging men and women.
Epidemiology , clinical characteristics , diagnostic procedures , therapeutic management and final outcome were recorded and analysed with SPSS @date@ .
Epidemiology has indicated that metabolic biomarkers are prospectively associated with cancer incidence and prognosis.
Epidermal differentiation markers loricrin , filaggrin , involucrin and transglutaminase , also strongly decreased.
Epidermal injury was demonstrated with acute up-regulation of keratin @number@
Epidermal Langerhans cells ( LCs ) act as sentinels of the immune system , recognizing , processing and presenting antigen and inducing T-cell responses.
Epidermal Sod2 loss induced cellular senescence , which irreversibly arrested proliferation in a fraction of keratinocytes.
Epidermal thinning and the decrease in collagen cause skin to lose its elasticity.
Epidermal thinning , declining dermal collagen content , diminished skin moisture , decreased laxity , and impaired wound healing have been reported in postmenopausal women.
Epidermis in children was thin ; it had a low content of Ki-67- and p53-positive cells and small thickness of involucrin-positive cell layer.
Epigenetic age acceleration at age @number@ was used as a predictor of longitudinal change in fitness.
Epigenetic age ( DNAmage ) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks.
Epigenetically changed hematopoietic stem cells may be involved in immunological aging as specific DNA regions become hypermethylated.
Epigenetically , modifications in hematopoietic stem cells may underlie uremia-associated immunological ageing , which is not reversed by kidney transplantation.
Epigenetic alterations and consequent changes in the neuronal transcriptome are now begun to be extensively studied in various neurodegenerative diseases.
Epigenetic and other unknown mechanisms underlying these developmental events are yet to be elucidated.
Epigenetic changes may alter the expression of genes involved in BP regulation and explain part of the missing heritability.
Epigenetic changes to chromatin are thought to be essential to cell senescence , which is key to tumorigenesis and aging.
Epigenetic clocks provide powerful tools to evaluate nutritional , hormonal , and genetic effects on aging.
Epigenetic drift and age-related methylation have both been used in the literature to describe changes in DNA methylation that occurs with aging.
Epigenetic drift-induced abnormal changes during aging are scantily repaired by epigenetic modulators.
Epigenetic drift is also influenced by genetic factors.
Epigenetic dysregulation , therefore , seems to also occur independently of the genetic background.
Epigenetic factors control gene expression and activity in response to environmental perturbations.
Epigenetic influences mediating brain iron deposition , oxidative mitochondrial injury , and macroautophagy in Parkinson disease and related conditions remain enigmatic.
Epigenetic inheritance refers to changes in gene expression that are heritable across generations but are not caused by changes in the DNA sequence.
Epigenetic machineries that include DNA and histone modifying enzymes and various non-coding RNAs have been identified as important contributors to nutrition-related longevity and aging control.
Epigenetic mechanisms encompass a complex regulatory network of modifications with considerable impact on health and disease risk.
Epigenetic mechanisms in Alzheimer's disease.
Epigenetic mechanisms in the brain are a series of post-translational chromatin and DNA modifications driven by external input.
Epigenetic mechanisms of this phenomenon are assumed.
Epigenetic mechanisms play a pivotal role in the expression of genes and can be influenced by both the quality and quantity of diet.
Epigenetic mechanisms refer to the complex and interrelated molecular processes that dynamically modulate gene expression and function within every cell in the body.
Epigenetic mechanisms such as DNA methylation and histone acetylation have been shown to be important for memory processes in the adult brain.
Epigenetic modifications and mitochondrial DNA haplogroups modulate ageing.
Epigenetic modifications help orchestrate sweeping developmental , aging , and disease-causing changes in phenotype by altering transcriptional activity in multiple genes spanning multiple biologic pathways.
Epigenetic modifications include DNA methylation , histone modifications , and small and long noncoding RNAs.
Epigenetic modifications of cytosine residues in the DNA play a critical role for cellular differentiation and potentially also for aging.
Epigenetic modifications such as DNA methylation are one potential mechanism through which such long-lasting impairments / consequences can be explained.
Epigenetic modifications to cytosine are known to alter transcriptional states and deregulate gene expression in cancer , embryonic development , and most recently in neurodegeneration.
Epigenetic nutritional research has substantial potential for AD and may represent a window of opportunity to complement other interventions.
Epigenetic processes are also considered important mechanisms through which environmental and stochastic stressors promote numerous pathologies in humans.
Epigenetic processes are central regulators of genome-environment interactions.
Epigenetic programs regulate the development and maintenance of organisms over a lifetime.
Epigenetic regulation of gene expression is well known mechanism that regulates cellular senescence of cancer cells.
Epigenetics can be defined as inheritable and reversible phenomena that affect gene expression without altering the underlying base pair sequence.
Epigenetics has recently emerged as another possible determinant of aging.
Epigenetics , in turn , can cause and is associated with several neurodegenerative and aging-dependent human diseases.
Epigenetics is an emerging field in ophthalmology and has opened a new avenue for understanding ocular development and ocular diseases related to aging and environment.
Epigenetics is defined as processes that induce heritable changes in gene expression without a change in the DNA nucleotide sequence.
Epigenetics is quickly emerging as a critical aspect of aging and longevity.
Epigenetics is the emergence of a new branch of genetics.
Epigenetics is , therefore , of considerable translational significance to the field of neuroprotection.
Epigenetics is the study of biochemical modifications carrying information independent of DNA sequence , which are heritable through cell division.
Epigenetics is the study of heritable and non-heritable genetic coding that is additive to information contained within classical DNA base pair sequences.
Epigenetics may provide the biologic link between these environmental factors and the transgenerational disparities that are observed.
Epigenetics provides an important layer of information on top of the DNA sequence and is essential for establishing gene expression profiles.
Epigenetics refers to the study of mechanisms able to influence gene expression in a stable and potentially heritable manner without altering the DNA sequence.
Epigenetics , transcending genetics , genomics , and molecular biology , is now poised to be the avant-garde beacon of biological science.
Epigenetic variations have been widely described to occur during the aging process.
Epigenetic variation with age is one of the most important hallmarks of aging.
Epigenomes allow to introduce additional mechanism of gene activation or silencing without affecting the DNA genome itself.
Epigenome-wide association studies ( EWASs ) were conducted on the four fitness measures.
Epigenome-wide DNA methylation patterns were compared between the two groups using the Illumina Infinium Human Methylation @number@ BeadChip microarray.
Epigenome-wide mapping studies in homogenous cell populations will inform our understanding of normal variation in the methylome that is not associated with disease or aging.
Epigenomics is the study of genome-wide epigenetic modifications.
Epilepsy genes deliver critical insights into the molecular control of brain synchronization and are revolutionizing our understanding and treatment of the disease.
Epilepsy in the elderly is a frequently occurring pathology , differing in etiology , clinical presentation and prognosis from those of young people.
Epilepsy type and medication status were not predictive of outcome.
Epilepsy variables , including history of olfactory hallucinations , were not predictive of olfactory ability.
Epilepsy was diagnosed in @percent@ ( 375 / 1014 ) of the study participants.
Epileptic EEG discharges occurred in @percent@ ( 870 / 1014 ) of the patients.
Epileptic pseudodementia is a pure disturbance of verbal episodic memory , stable over time.
Epileptic spasms may occur in the context of a variety of syndromes.
Epileptic spasms occurred predominantly during wakefulness ( p < @number@ ) and during daytime ( p < @number@ ) .
Episodic and semantic ABM impairment represent an important AD prodrome.
Episodic heavy drinking-even when average consumption remains moderate-is a significant public health concern.
Episodic increases in InhB occurred in 17 / 20 cycles prior to the LH surge.
Episodic memory enables the detailed and vivid recall of past events , including target and wider contextual information.
Episodic memory , executive function , semantic processing , and estimated verbal intelligence were assessed.
Episodic memory is a complex memory system which allows recall and mental re-experience of previous episodes from one's own life.
Episodic memory is a core feature of Alzheimer's disease ( AD ) and mild cognitive impairment ( MCI ) .
Episodic memory regressed positively on leisure-time PA ( LPA ) and cognitive activity.
Episodic memory tasks appear to have predictive power for indicating early AD.
Episodic memory was affected by such agents , wheras semantic memory was spared.
Episodic memory was assessed using the old-new face recognition paradigm in which memory for younger and older faces was tested.
Episodic memory was associated with hippocampal volume and MD of the cingulum and fornix.
Epistatic and biochemical experiments show that this inhibition occurs at the cell membrane level through regulation of LRP6.
Epithelial cancers of the elderly are caused by a combination of telomere dysfunction and the mutational invalidation of major tumor suppressors including p53.
Epithelial cells turnover rapidly and mutations naturally accumulate throughout life.
Epithelial expression of S100A8 / 9 is partly regulated by the IL-6 trans-signaling pathway.
Epithelial-mesenchymal transition ( EMT ) is an important developmental process hijacked by cancer cells for their dissemination.
Epithelial stem cells exhibit increased mitochondrial mutation in aging that affects their progeny in the mucosal epithelium.
Epithelial-to-mesenchymal transition ( EMT ) plays a significant role in tubulointerstitial fibrosis , which is a hallmark of diabetic nephropathy.
Epitope-mapping studies revealed evidence of intra-molecular cross-reactivity.
EPO levels in the AUE group were increased relative to controls but were inappropriately low for the degree of anaemia.
Epstein-Barr virus ( EBV ) is detected in @percent@ to @percent@ of sporadic Burkitt lymphoma ( sBL ) .
Epub @date@ . doi : 10.2519 / jospt.2016.6597.
Epub @date@ . doi : 10.2519 / jospt.2017.7229.
EQ-5D index and EQ-VAS scores were significantly lower in patients with cognitive impairment.
Equally , non-expert graders recorded the SS formulation superior to its placebo.
Equally notable , we observed numerous pinocytic vesicles within engrafted cells.
Equal proportions of participants were recruited at low , medium and high nutrition risk based on their SCREEN II score @number@ months prior.
Equations were fit to the data to give torque-angle ( Tθ ) and torque-angular velocity ( Tω ) relations.
Equatorial and sagittal cortex thickness increased linearly with age at @number@ mm per year.
Equatorial lens diameter increased ( @number@ ± @number@ mm ) with no change in the posterior lens surface radius of curvature.
Equipercentile equating identified Sweet @number@ cut points that correlated with widely used MMSE cut points.
Equivalent scores and cut-off scores were then determined for UDs and CSs.
Equivalent translated instruments help researchers from different cultures to find a common language and undertake comparative research.
Equivocal results were found for executive function.
ER22 / 23EK polymorphism of the GC-R gene has a low prevalence in our population.
ER22 / 23EK was found in @percent@ of the subjects and carriers had a lower prevalence of hypertension.
Eradicating specifically these hypoxic cells is one of the many goals of anticancer therapies.
Eradication therapy consisted of @number@ mg lansoprazole plus @number@ mg amoxicillin and @number@ mg clarithromycin twice daily for @number@ d.
ERAS pathway has been proven to be beneficial for patients , which results in a reduction of postoperative morbidity.
ERAS program applied to colorectal laparoscopic surgery is well known to reduce hospitalization improving short terms outcomes and minimizing the Surgical Stress Response.
ERCC1-XPF is a structure-specific endonuclease required for nucleotide excision repair , interstrand crosslink repair , and the repair of some double-strand breaks.
Erectile dysfunction and low sexual desire are multifactorial diseases.
Erectile dysfunction ( ED ) and low testosterone levels are common in men with type @number@ diabetes ( T2D ) .
Erectile dysfunction ( ED ) is a common condition in aging men , with a prevalence of @percent@ in men aged @number@ to @number@ years.
Erectile dysfunction ( ED ) is a common disorder among aging males.
Erectile dysfunction ( ED ) is one of the most common disorders in male and is often associated with other age-related comorbidities.
Erectile dysfunction is a problem in men increasing with age.
Erectile dysfunction is closely linked to the general state of both physical and psychological wellness.
Erectile dysfunction , premature ejaculation and prostate disorders are also prevalent.
Erectile function domain , orgasmic function domain , sexual desire domain , intercourse satisfaction domain , and overall satisfaction domain improved.
Erectile functions of the patients were evaluated by International Index of Erectile Function ( IIEF ) .
Erectile function was measured with one question from the FACT-P similar to that used by the Massachusetts Male Aging Study.
ERG comparisons showed that older DJ-1 KO mice had reduced sensitivity under dark- and light-adapted conditions compared to age-matched control.
Erik H. Erikson published his groundbreaking theory of @number@ stages of lifelong psychosocial development in @number@
Eroded endocortical perimeter ( E.Pm / Ec.Pm ) correlated positively with superior cortical width.
Er of GA groups remained stable over time at the hybrid layer and underlying dentin.
Er of the adhesive , hybrid layer and underlying dentin was evaluated after 24h and @number@ months in artificial saliva.
ERP analyses were used to measure the P3b component as an electrophysiological correlate of context updating.
ERP indices were unrelated to participants ' intellectual functioning , but did correlate with age and caregiver-reported lethargy / withdrawal behaviors.
ERP low-resolution electromagnetic tomography revealed that modafinil improved information processing speed and increased energetic resources in prefrontal cortical areas.
ER positive tumors scored by Citizen Scientists were associated with survival in a similar way to that scored by trained pathologists.
ERP results indicated that only compounds evoked an early frontal old / new effect in older adults.
ERPs locked to the preparatory cues in the test phases indicated that participants did not establish retrieval mode on switch trials in Experiment @number@
ERPs of older adults did not show such increases , suggesting reduced memory functioning.
ERP studies with a focus on normal aging are specifically analyzed because they contribute to a deeper understanding of inhibition.
ERPs were recorded from healthy young and old adults of either high or average EC based on neuropsychological testing.
ERPs were recorded in response to unfamiliar urban and nature scenes , with some images presented once and others repeated multiple times.
ERPs were recorded using the auditory \ "odd-ball \ " paradigm.
ERP were recorded at @number@ healthy subjects from @number@ to @number@ ages and @number@ subjects from @number@ to @number@ ages.
Errands and eating were the most common purposes for transportation trips.
Erratic eating patterns can disrupt the temporal coordination of metabolism and physiology leading to chronic diseases that are also characteristic of aging.
Erroneous categorization may result if variants affect genes that are in fact dispensable.
Error analysis and the comparison to the literature reveal that the OLSa could be a useful tool to assess IM.
Error commission rates on executive functioning tests are significantly associated with both age and education.
Errorless learning ( EL ) is a principle used to teach new information or skills to people with cognitive impairment.
Error patterns indicated that navigational sequences were increasingly retained as global paths across development , in contrast to separately stored reaching locations.
Errors in chromosome segregation in mammalian oocytes increase in number with advancing maternal age , and are a major cause of pregnancy loss.
Errors in chromosome segregation in oocytes and early embryos lead to embryo aneuploidy , which contributes to early pregnancy loss.
Errors in the direction of the initial weight transfer ( APA errors ) and the step execution times were measured from the vertical force data.
Error , temporal and kinematic variables were used to assess the matching performance.
ER stress enhances the susceptibility of structural cells , in most cases the epithelium , to pro-fibrotic stimuli.
Eruca sativa Mill. , commonly known as rocket , is a leafy vegetable that has anti-inflammatory activity.
ER visits and hospitalization were higher among depressed subjects.
Er : YAG laser-etching may be an alternative enamel etching method to acid-etching for ACP-containing FS.
Eryptosis eliminates infected or defective erythrocytes thus counteracting parasitemia in malaria and preventing detrimental hemolysis of defective cells.
Eryptosis is triggered by a wide variety of xenobiotics.
Erythema and pigmentation were measured using a Mexameter.
Erythrocyte creatine levels ranged from @number@ to @number@.36μmol / g hemoglobin.
Erythrocyte hyperaggregation , a cardiovascular risk factor , is considered to be caused by an increase in plasma adhesion proteins , particularly fibrinogen.
Erythrocyte membrane fluidity was assessed by fluorescence spectroscopy.
Erythrocyte rheological and central / peripheral hemodynamic characteristics were determined by slit-flow ektacytometer and bioreactance-based device / near infrared spectrometer , respectively.
Erythrocytes and platelets are anucleate blood cells that are indispensable for oxygen delivery and hemostasis , respectively.
Erythrocytes are the most numerous cells in human body and their function of oxygen transport is pivotal to human physiology.
Erythrocytes have been extensively studied both experimentally and by mathematical modeling in recent years.
Erythrocytes ( RBC ) were selected as the model system since , lacking protein synthesis apparatus , they are unable to replace damaged proteins.
Erythrocytes were incubated with PTX in the presence and absence of NAR.
Erythromycin-resistant strains ( @percent@ ) were also clindamycin-resistant and positive for erm ( B ) .
Erythropoietin levels were determined at age @number@
ER-β , encoded by ESR2 , is the ER predominantly expressed in vascular smooth muscle.
ERβ genetic polymorphisms have been associated with cognitive impairment and increased risk for AD predominantly in women.
ESBL-E are known to colonize different body sites and cause bloodstream infections ( BSI ) , pneumonia , intra-abdominal infections and urinary tract infections.
Escitalopram ( n = 3298 ) was administered at doses between @number@ and 20mg / day.
Escitalopram-placebo differences in mean changes in ECG values were not clinically meaningful.
Escitalopram was significantly superior to placebo for improving sleep disturbance over the 24-w treatment period.
Esculetin not only increased protein levels of type I procollagen but also increased mRNA levels of COL1A1 but not COL1A2.
ESFTs are genetically related to NCSC , permissive for EWS-FLI1 expression and susceptible to oncogene-induced immortalization.
ESI > 3.7 g / day was associated with larger left atrial and left ventricular dimensions ( p < @number@ ) .
Es lo que han hecho Martínez Carrión y cols. , con el trabajo que aparece en este número de Nutrición Hospitalaria.
Esophageal cancer represents one of the most aggressive digestive tumors , with a survival rate at @number@ years of only @percent@.
Esophageal small-cell carcinoma expressed higher levels of glandular markers and lower levels of squamous-basal markers than poorly differentiated squamous cell carcinoma.
Esophageal ulcer might be a rare but unique lesion.
Especially , atrial wall movement by high-frequency fibrillation had a large impact on the stagnation of blood flow.
Especially , BMPs are well known to be the main inducers of bone formation , by facilitating both proliferation and differentiation of bone stem cells.
Especially , certain aspects of cardiac electrophysiology of the zebrafish such as action potential or heart rate are similar to that of humans.
Especially , cytokines , and growth factors are useful candidates and markers for the determination of wound vitality or age.
Especially , elderly diabetic patients who are started to liraglutide treatment should be monitored closely for the formation of cholelithiasis.
Especially , future strategies of prediction and prevention , and the evaluation of antipsychotics from a safety perspective , are presented.
Especially girls crouch over the toilet seat and train to empty the bladder without relaxation of the pelvic floor.
Especially important roles in cell signaling and gene regulatory mechanisms make tocopherols crucial as therapeutic agents.
Especially in elderly patients , donor-site comorbidities are fewer due to the redundant aging skin and the missing tooth.
Especially in women using a seeking social support strategy , there was a lower risk of depression.
Especially , it is important to examine the cardiovascular and respiratory functions in the elderly patient.
Especially marked are the changes during the first year of life.
Especially older adults were not able to overcome the cost of the dual-task situation.
Especially regarding precursor lesions , the therapeutic options are numerous and should be adapted to the individual patient.
Especially , safety margin for the amount of acceptable mechanical stress is narrow in the elderly due to preexisting musculoskeletal problems.
Especially , social influence had the strongest mediating effect.
Especially , the increased stent height compared with the XT and the newly added polyethylene terephthalate cuff is of potential concern in ViV interventions.
Especially the older participants benefited from knowing the future target position in advance , indicated by reduced response times after informative cues.
Especially T lymphocytes are functioning insufficiently : their reactivity towards their antigen diminishes and alterations take place in the proportions of their functional subgroups.
Especially , we appreciate recent advances in molecular function of the complex assembled by these transcription factors and epigenetic regulation of them.
Especially with Genome Alterations and Proteonomics.
Especially with increasing age most of the everyday ways in urban areas are covered by foot.
ESR2 variants were not significantly associated with brain measures , but women with the ESR1 rs2234693 C allele had significantly smaller WML.
ESR2 was not related to age or menopause.
Essence of Chicken ( EC ) is a nutritional supplement that is traditionally made by extracting water soluble substances derived from cooking the whole chicken.
Essential for MsrA action in the lens and other tissues is the availability of a reducing system sufficient to catalytically regenerate active MsrA.
Essentially , PrxII depletion hampers the PARP-dependent Axin1 degradation through tankyrase inactivation.
Essentially , the disease replaces functional lung tissue with spreading scar tissue over a period of just @number@ years.
Essential polyunsaturated fatty acids ( PUFAs ) have profound effects on brain development and function.
Essential to the thesis is that small , electron dense , non-vesiculated L-forms are the central ( core ) element in bacterial persistence.
Essential tremor ( ET ) is among the most common neurological disorders.
Established and developing antiplatelet therapies for the treatment of thrombotic and inflammatory disorders are also discussed in light of these data.
Established entities include progressive supranuclear palsy , corticobasal degeneration , Pick's disease , and argyrophilic grain disease.
Established in @number@ the Center is a clinical laboratory for testing the validity and utility of a health-focused rather than disease-focused care setting.
Established techniques of geriatric evaluation and management allow systematic assessment and intervention on multiple components by multidisciplinary teams and deliver the best outcomes.
Establishing clinical norms using the one selected method to verify reliability within and across clinicians is suggested before examination with a disordered population.
Establishing differential conversational profiles could help the timely differential diagnosis of memory complaints.
Establishing in vivo platforms to modulate age-associated epigenetic marks may provide further insights into the biology of aging.
Establishing methods for ascertainment of dementia and cognitive impairment that are accurate and also cost-effective is a challenging enterprise.
Establishing national minimum standards of nursing care to be delivered towards older people admitted in Italian medical units is recommended.
Establishing proper epigenetic modifications during oogenesis and early embryo development is an important aspect in reproduction.
Establishing the most frequent allergens responsible for allergic contact dermatitis in the elderly is a hard task.
Establishment of pathogenic relevance of predictive biomarkers such as ours may not only facilitate early diagnosis , but may also help identify new therapeutic avenues.
Estimated 10- and 15-year risks of clinically manifest colorectal cancer were @percent@ and @percent@ or lower , respectively , in all groups assessed.
Estimated age of peak was around age of @number@ for trabecular vBMD and microarchitecture and Ct.Po and age of @number@ for cortical vBMD and microarchitecture.
Estimated bone mineral density ( eBMD ) was derived as a function of the QUS parameters speed of sound and broadband ultrasound attenuation.
Estimated counts of the US HIV-infected and AIDS populations were obtained from Centers for Disease Control and Prevention surveillance data.
Estimated declines were greatest in participants who did not wear a hearing aid.
Estimated dietary TFA was not significantly associated with DM.
Estimated ED visit incidence rate for persons aged 85 + years old was twice as high as for persons aged 65-84 years.
Estimated energy and nutrient intakes at the centers and at home were assessed and related to Recommended Nutrient Intakes ( RNI ) .
Estimated free IGF-1 did not increase with age in transgenic mice , as it did in wild-type mice.
Estimated GFRCYSC classified a larger proportion of HIV-infected men with CKD compared with eGFRSCR.
Estimated GFR ( eGFR ) was calculated with three chronic kidney disease epidemiology collaboration ( CKD-EPI ) formulas involving cystatin C , creatinine or both.
Estimated glomerular filtration rate ( eGFR ) was calculated according to the Chinese simplified MDRD equation.
Estimated glomerular filtration rate ( eGFR ) was calculated by the Modification of Diet in Renal Disease ( MDRD ) study equation.
Estimated glomerular filtration rate ( eGFR ) was calculated using serum creatinine level , age and sex.
Estimated glomerular filtration rate ( eGFR ) was estimated using the Modification of Diet in Renal Disease equation ( Chinese version ) .
Estimated glomerular filtration rate was calculated using the Modification of Diet in Renal Disease formula.
Estimated incidence of chronic otitis media in Pacific Island nations is 3-5 times greater than other Australasian countries in children under @number@ years old.
Estimated incidence rates were validated with observed incidence rates obtained from the Umbria regional cancer registry.
Estimated median IELTs were @number@ minutes for DE vs @number@ minutes for no DE ( P < @number@ ) .
Estimated median MELTs were @number@ minutes for DE vs @number@ minutes for no DE ( P < @number@ ) .
Estimated NEAP and PRAL were not associated with BMD at any site among Original cohort women or Offspring cohort men and women.
Estimated postural VC difference and percentage also decreased ( P < @number@ P = @number@ respectively ) .
Estimated probabilities of 2-year transitions among disability states and mortality are presented for adults aged @number@ and older.
Estimated stiffness and failure load peaked at mid-30s at the distal radius and at age @number@ at distal tibia.
Estimated values of the BBS and the COVS can be calculated from the equation.
Estimates are lower than reported using single estimates of GFR , emphasizing the importance of confirming estimates of reduced GFR in studies of CKD.
Estimates decreased after adjustment for fine particles ( PM2.5 ) or nitrogen dioxide ( NO2 ) .
Estimates did not change after controlling for environmental variables.
Estimates in women were @number@ years and @number@ years , respectively.
Estimates of DAT loss per decade were obtained using the values from the regression slopes.
Estimates of hospitalizations and deaths associated with domestically acquired Salmonella ( accounting for under-reporting ) were also calculated.
Estimates of inequity remain unchanged when we incorporate information on unmet need in the analysis.
Estimates of lens opacification , however , generally rely on subjective rather than objective measures in clinical practice.
Estimates of main and interactive effects are derived from logistic regression models.
Estimates of @number@ day postoperative mortality were calculated according to projected demographic data.
Estimates of phosphocreatine ( PCr ) and adenosine triphosphate ( ATP ) in homogeneous gray and white matter were obtained by tissue regression analysis.
Estimates of prostate cancer cases are often based solely on changes in the age distribution of the population or on historical trends.
Estimates of recollection , but not familiarity , showed a significant negative correlation with chronological age.
Estimates of the economic cost of lost productivity varied widely , from $ 1.8 to $ 194 billion in the United States.
Estimates of the size of older-age populations and their attributable disease burden should be reconsidered.
Estimates of working memory ( WM ) capacity increase in children , peak in young adulthood , and decline thereafter.
Estimates put the genetic effect from @number@ to @percent@ approximately , suggesting that even genetic effects are dependent on environmental conditions.
Estimates were pooled using a random-effect model ( DerSimonian and Laird method ) .
Estimating the age of a human from the captured images of his / her face is a challenging problem.
Estimation of age at death from adult skeletal remains is highly problematic , due in great part to interpopulation variability in skeletal age changes.
Estimation of the SACE using a sensitivity analysis approach should be considered when conducting epidemiological research within elderly populations.
Estimation results reveal that online and conventional health services are complementary for enhancing health status in an aging society.
Estimations of binding potential in the caudate , putamen , substantia nigra , and thalamus were individually regressed according to age using simple regression analysis.
Estimations of the age at which children learn the words revealed significantly lower ratings of AoA.
Estradiol activated estrogen receptor ( ER ) α to recruit repressor of estrogen receptor activity ( REA ) and form the ERα / REA complex.
Estradiol ( E2 ) may also be associated with MetS , but few studies have investigated this.
Estradiol effects on memory depend on hormone levels and the interaction of different estrogen receptors within neural circuits.
Estradiol has been shown to inhibit Th17 differentiation and production of antifungal IL-17 cytokines.
Estradiol induced Rea mRNA and protein expression in mouse splenocytes.
Estradiol was significantly higher in BPH ( p = @number@ ) .
Estrogen actions on serum lipids mostly occur through its binding to intracellular Estrogen Receptor alpha ( ERalpha ) isoform , expressed in most of tissues.
Estrogen also modulates osteoblast / osteocyte and T-cell regulation of osteoclasts.
Estrogen and progesterone levels play the biggest part in menopause.
Estrogen appears to protect most women against hypertension , with incidence increasing after menopause.
Estrogen-based hormone replacement therapy ( HRT ) may be associated with deceleration of cellular aging.
Estrogen-based therapies have long been the treatment of choice for women suffering from VMS.
Estrogen concentration in women may have limited effects on symptoms associated with muscle damage , but further research in this area is warranted.
Estrogen coordinates brain and body metabolism , such that peripheral metabolic state can indicate bioenergetic status of the brain.
Estrogen deficiency is detrimental to many wound-healing processes , notably inflammation and re-granulation , while exogenous estrogen treatment widely reverses these effects.
Estrogen deficiency or over-activity may cause ovarian tissue aging or tumorigenesis , respectively , through estrogen regulation of telomere remodeling.
Estrogen exerts profound effects on human physiology including articular cartilage and MSCs.
Estrogen has a plethora of effects in the cardiovascular system.
Estrogen is a fundamental regulator of the metabolic system of the female brain and body.
Estrogen is an important regulatory hormone of BBB permeability.
Estrogen is effective for the treatment of dyspareunia associated with genitourinary syndrome of menopause.
Estrogen is the major hormonal regulator of bone metabolism in women and men.
Estrogen modulates adrenergic reactivity of macrovessels , resulting in weaker α-adrenergic vasoconstriction in females than males.
Estrogen receptor α ( Erα ) immunoreactivity was more intense in the epithelium in the PC and HGPIN groups.
Estrogen receptor-α ( ER-α ) may mediate estrogen's beneficial actions via its effects on the cerebral microvasculature.
Estrogen receptor β ( ERβ ) immunoreactivity was weak in the epithelium of the HGPIN and PC groups.
Estrogens and androgens influence the growth and maintenance of the mammalian skeleton and are responsible for its sexual dimorphism.
Estrogens enhance cell proliferation and progression of the tumor.
Estrogen sensitive , specific circulating microRNAs could be potential , early biomarkers for age-associated physiological deteriorations.
Estrogens have been shown to be protective agents against neurodegeneration and associated cognitive decline in aging females.
Estrogens have been shown to have protective effects on a wide range of cell types and animal models for many neurodegenerative diseases.
Estrogens play an important role in the regulation of normal physiology , aging and many disease states.
Estrogens , progestins and androgens have all been shown to have effects on nerve growth and function in vitro.
Estrogen therapy increases osmotic sensitivity for mechanisms to retain body water so may help menopausal women control body fluids and avoid dehydration.
Estrogen treatment in eugonadal men diminishes libido , whereas libido is preserved by estrogens in orchidectomized transsexuals as well as in cases of aromatase deficiency.
Estrogen was higher ( p < @number@ ) in the luteal group.
Estrone , total and free estradiol , and total and free testosterone levels were measured at time of the first testing.
Estrone , total and free estradiol , and total and free testosterone levels were measured at time of the first testing.
ET-1 exerts its biological actions through the activation of two receptors : ETA and ETB.
ET-1 overexpression may induce vascular injury by inducing changes in gene expression.
ET-1 upregulation with aging was also seen in ≈70-year old ( vs. ≈30-year old ) human heart sections.
ET also increased skeletal muscle content of the mitochondrial deacetylase SIRT3 in both groups.
Etanercept seems to be well tolerated , possibly because of its lower immunosuppressive characteristics compared with other biologics.
ETC-1002 has a unique mechanism of action ( adenosine triphosphate-citrate lyase inhibition ) .
Etched ceramic surfaces were treated with a silane agent.
ET does however increase muscle and mitochondrial antioxidant capacity in older individuals , which provides increased buffering from the acute oxidative effects of exercise.
Etheno ( ε ) DNA base adducts are highly mutagenic lesions produced endogenously via reactions with lipid peroxidation ( LPO ) products.
Ethical and health risk taking reduce relatively smoothly with age.
Ethical approval was granted for an online survey.
ETHICAL CONSIDERATIONS : The ethical principles of informed consent , confidentiality and non-identification were respected.
ETHICAL , SCOPE AND CONTEXT : The definition of a geriatric patient is reviewed.
ETHICS AND DISSEMINATION : The Ethics Committee of Nordwest-und Zentralschweiz approved this study ( EKNZ 2014-209 ) .
ETHICS AND DISSEMINATION : The protocol is approved by the host institution's ethics committee under the number @number@
ETHICS AND DISSEMINATION : The study has been conducted according to the SPIRIT statement.
ETHICS AND DISSEMINATION : This systematic review is exempt from ethics approval because the work is carried out on published documents.
Ethiology of nocturia might be polyuria , nocturnal polyuria or reduced bladder capacity.
Ethnic and genetic differences modify skin structure and function.
Ethnic difference in telomere length might primarily be explained by genetic factors.
Ethnic differences in disease prevalence and mortality must be understood to better care for the oldest old.
Ethnic differences in skin characteristics are widely accepted , but poorly described.
Ethnic differences were found in SBP and DBP levels ( p < 0 , 001 ) .
Ethnic disparities in survival were evaluated using Kaplan-Meier and multivariate Cox proportional hazards models.
Ethnic disparities persisted among individuals who , based on income and assets , are considered appropriate for purchasing private LTCI coverage.
Ethnic inequalities persisted or even increased from earlier periods to 2006-2009.
Ethnicity and cultural experience can affect neuropsychological performance , but they are rarely assessed in historical context.
Ethnicity and sex by sleep interactions were also entered into the models.
Ethnicity did not significantly interact with any covariates in determining telomere length , including psychosocial characteristics.
Ethnicity , gender and age had no significant impact on the quantity of RSSC recovered from the skin surface.
Ethnicity was related to social networks and health but this was largely accounted for by other contextual variables measuring socioeconomic status.
Ethnographic content analysis was used to identify themes and categories.
ETHNOPHARMACOLOGICAL RELEVANCE : Achyranthes L.
ETHNOPHARMACOLOGICAL RELEVANCE : Anemarrhena asphodeloides Bunge.
ETHNO-PHARMACOLOGICAL RELEVANCE : Cyperus rotundus L.
ETHNOPHARMACOLOGICAL RELEVANCE : Cyperus rotundus L.
ETHNOPHARMACOLOGICAL RELEVANCE : Eucommia ulmoides Oliv.
ETHNOPHARMACOLOGICAL RELEVANCE : Heshouwu , the root of Polygonum multiflorum , is an anti-aging Chinese traditional medicine.
ETHNOPHARMACOLOGICAL RELEVANCE : Perilla frutescens ( L. )
ETHNOPHARMACOLOGICAL RELEVANCE : Polygonum multiflorum Thunb. , which is known as Heshouwu ( in Chinese ) in China.
ETHNOPHARMACOLOGICAL RELEVANCE : Postmenopausal osteoporosis is the most common bone disease worldwide.
ETHNOPHARMACOLOGICAL RELEVANCE : Several species from the genus Hippocampus have been widely used as a traditional medicine or invigorant with long history in China.
ETHNOPHARMACOLOGY RELEVANCE : Oldenlandia diffusa ( OD ) has long been known as an apoptotic inducer in breast tumors in ethnomedicine.
ET however , increased the activity of the endogenous antioxidants in older participants.
Etiologic fractions were calculated to obtain the nursing home costs attributable to diabetes and its clinical and functional complications.
Etiologies of stroke affecting the retina , optic nerve , optic radiation , and visual cortex overlap with other types of ischemic strokes.
Etiology distribution was different between severe AP and mild AP ( P < @number@ ) .
Etiology of otitis media with effusion ( OME ) is still unclear and often described as multi-factorial.
E-type cyclins ( cyclins E1 and E2 ) are components of the cell cycle machinery that has been conserved from yeast to humans.
Eubacterium rectale and Dorea longicatena were less abundant in the gut microbiota of HF patients than in that of HC subjects.
Eucalyptus globulus is an evergreen tree that is widely used in cosmetics because of its antimicrobial activity.
Eucalyptus globulus was also found to regulate TGF-β / Smad signaling by reversing the activity of negative Smad regulators.
Euclidean geometry was used to calculate the distance between projected electrode entry and target with increasing age.
EUDRA-CT 2010-020941-29. ) .
EudraCT 2014-005121-13.
Eukaryotic cells have two main routes for clearing misfolded or toxic proteins : the ubiquitin-proteasome and autophagy-lysosome pathways.
Eukaryotic cells possess several organelle-specific stress responses to cope with this challenge.
Eukaryotic cells use autophagy and the ubiquitin-proteasome system as their major protein degradation pathways.
Eukaryotic gene expression is tightly regulated post-transcriptionally by RNA-binding proteins ( RBPs ) and microRNAs.
Eukaryotic gene expression is tightly regulated transcriptionally and post-transcriptionally by a host of noncoding ( nc ) RNAs.
Eukaryotic genomic DNA is highly packaged into chromatin by histones to fit inside the nucleus.
Eukaryotic mRNA decay is tightly modulated by RNA-binding proteins ( RBPs ) and microRNAs ( miRNAs ) .
EULAR good or moderate responses were achieved in @percent@ of patients.
Eur.
Euro-Canadian children showed larger reverse telescoping than Chinese children.
EUROCARE-5 assesses their effect on cancer survival in @number@ European countries.
European comparisons suggest , however , that our system could be made more efficient without undermining public health.
European Journal of Cognitive Psychology , @number@ 415-436 ] .
European welfare states were based on a balanced combination of three values : freedom , equality , and solidarity.
EuroSCORE II was confirmed to be the only independent predictor of MACE after RA.
EUR was strongly associated with a high caregiver burden ( OR @number@ @percent@ CI @date@ @number@ ) .
EUS can be regarded as a safe and effective procedure in ≥ @number@ years old population.
Euthymia and mood elevation decreased with progressing female reproductive stage.
Evaluating fracture risk on the basis of a sound understanding of the various etiologies of osteoporosis is important when treating osteoporosis.
Evaluating the accuracy and robustness of developed methods is difficult due to the lack of a biologically realistic ground truth.
Evaluating the predictive ability of mortality forecasts is important yet difficult.
Evaluating working memory and attention in schizophrenia patients is usually based on traditional tasks and the interviewer's judgment.
Evaluation and data collection methodologies based on existing experience with MAST and MEDAL methodologies ; and @number@
Evaluation and treatment of microvascular and macrovascular complications of diabetes in elderly must also be individualized.
Evaluation at day @number@ included standardized photographs and patient and investigator assessments.
Evaluation by HR-SEM , micro-Raman , circular dichroism , in combination with molecular modeling of individual domains and whole OC90.
Evaluation : Facilitators and barriers to order sets use at the two sites were evaluated.
Evaluation of arterial compliance is significant in cardiovascular diagnosis for early detection of coronary heart disease.
Evaluation of cell reactions is the first step in the diagnostic procedure.
Evaluation of changes in laryngeal cancer incidence in the population of Kazakhstan was performed using component analysis.
Evaluation of diastolic function can also be performed by CMRI.
Evaluation of effectiveness of intervention and cost-benefit analyses will be important to ensure cancer control in the future.
Evaluation of explosive grip force generation using RGFD may be used as an assessment tool , providing more detailed information on the grip function.
EVALUATION : Offered is a literature review and definitions of the four different generational groups evident in the current nursing workforce.
Evaluation of FOXP1 expression in clinical samples indicated that the decreased expression of FOXP1 is another prognostic factor of prostate cancer.
Evaluation of gene expression changes in different neurons suggests specific transcriptomic signature of single neurons during aging.
Evaluation of GHD in pediatrics and after transition was conducted following consensus guidelines.
Evaluation of independent and combined interrelations of bronchial obstruction and autonomic regulation of cardiac rhythm in elderly patients with bronchial asthma was carried out.
Evaluation of magnitude-based inferences indicated the progressive resistance training intervention to be likely beneficial for improving static balance performance.
Evaluation of model performance using the test set showed a comparable result ( MAD @number@ years , RMSE @number@ years ) .
Evaluation of mtDNA quantification and the measurement of ooplasmic and blastomere volume may be useful for selection of high quality embryo and pregnancy outcome.
Evaluation of PABPN1 mRNA polysomes indicated that PABPN1 translation was modulated positively by HuR and hence negatively by CircPABPN1.
Evaluation of patients was based on pre and postoperative CT-scans associated with clinical follow-up with a minimum of @number@ months.
Evaluation of platelet aggregation is essential to monitor therapeutic effects of sarpogrelate.
Evaluation of potential candidates for testosterone replacement therapy ( TRT ) includes a complete medical history , physical examination , and hormonal screening.
Evaluation of the modules by users has been strongly positive.
Evaluation of the proposed methods was carried out using the cardiovascular heart study ( CHS ) dataset.
Evaluation of this organization has revealed that large-scale brain networks consist of multiple segregated subnetworks of interacting brain areas.
Evaluation questionnaires revealed that participants had favorable reactions to the workshops with respect to utility and interest.
Evaluations indicated caregivers and referring providers found the appointment helpful in managing behavioral symptoms and caregiver stress.
Evaluations of candidate interventions should control for other related factors that are not modifiable.
Evaluations of the effectiveness of these models tend to focus on process measures rather than outcomes for the older person.
Evaluations of the seminar suggest that it is feasible to develop educational programs targeting healthcare professionals and community health practitioners.
Evaluations were done for up to @number@ months.
Evaluations were performed @number@ days and @number@ months after treatment by both patients and clinicians.
Evaluations were performed pre and post-intervention , for isokinetic muscular strength of the elbow flexors and extensors and functionality of the upper limbs.
Evaluations were positive and sustained.
Evaluations were repeated on days @number@ and @number@
EVALUATION : This review considers evidence-based research as well as reports , case studies and literature reviews related to transitional care.
Evaluation times involve inclusion ( randomization ) and follow-up ( @number@ months ) .
Evaluators invited to participate were part of the following categories : elderly people , caregivers and speech-language therapists.
Even after adjustments for these confounding variables , age did not play any significant role as drop-out predictor.
Even after cognitive enhancers were prescribed , some respondents continued to believe that the dementia symptoms were ' normal'.
Even after controlling for CPD , e-cigarette expenditures or use was associated with greater odds of wheezing and shortness of breath.
Even after the failure of @number@ eradication therapies , a fourth empirical rescue therapy ( with rifabutin ) can be effective.
Even a minor level of apathy without major depression would have a significant impact on activities of daily living and quality of life.
Even among those who previously participated to a self-questionnaire based study , the response rate was only @percent@.
Even a more subtle weight change than suggested previously was associated with lower old age cognition.
Even as little as three years of schooling was found to be a significant protective factor against the incidence of dementia only for women.
Even at 16years MCTs were higher than that for adults ( independent t-tests , p < 0.05 ) .
Even at Cbl levels ⩾800 pg / ml , MMA values were increased in @percent@ of elderly subjects with at least one oxidant risk.
Even being a safe procedure , the dermal filling needs to be done by trained professionals because some complications may occur.
Even dyads who agree about participation may need additional support for successful engagement.
Even fewer studies have addressed the treatment strategies used to support these institutionalized patients , who are mostly in advanced stages of the disease.
Even for those who are competent in using inhalers , the evidence for their efficacy in older patients is not certain.
Even high-risk older adults can be successful in an HCE exercise program and experience no adverse physical or emotional changes.
Even if adults preferred cups with coloured contents in multi-dental treatment sessions , children regularly preferred water ( p < 0.001 ) .
Even if it is true , we do not know the clinical significances of pancreatic fat accumulation.
Even if less pronounced also for the other parameters computed these differences emerged.
Even if patients with CKD or ESRD could be given the least expensive therapies , costs would decrease only marginally.
Even if pelvic floor dysfunction is more common after vaginal delivery compared to cesarean section , the differences are less clear after long-term follow up.
Even if the physician cannot serve as the planning facilitator , the physician should ensure that this task is done well.
Even individuals with mild cognitive impairment ( MCI ) offer a great opportunity to test them.
Even in healthy individuals , renal function gradually declines during aging.
Even in healthy subjects , the heart ages along with other organs of the body.
Even in integrated health systems , repeat ED visits are frequent and expensive , despite minimal social causes of acute care.
Even in preclinical models , testing interventions to extend healthspan in old age are lengthy and therefore costly.
Even in recurrent disease , @number@ % of surgeries resulted in sustained correction of the lid malposition.
Even in the developed world , an increasing number of people consume nutrient-poor food on a regular basis.
Even in young survivors with normal menstrual cycles , hormone and ultrasound measures of ovarian reserve suggest decreased underlying ovarian reserve than age-matched healthy women.
Even lay persons know that a sedentary lifestyle is unhealthy.
Even longer term monitoring of @number@ months to @number@ year with external and implantable loop recorders improves rates of diagnosing AF.
Even loss of ejaculated spermatozoa does not necessarily exclude paternity since testicular sperm extraction has been established in men with obstructive or non-obstructive azoospermia.
Even mildly depressed LVEF is independently associated with cognitive impairment.
Even more , beta-carotene , vitamin A , and vitamin E may increase mortality.
Even more concerning is the increase in vascular risk factors among Canada's youth , and ethnically diverse populations.
Even more pronounced effects were seen in @number@.7-3.2-year-old mice exposed to @percent@ caloric restriction starting at @number@ years of age.
Even more serious implications lie in the capacity to make treatment choices.
Even nowadays a large proportion of the population in this area still follows the traditional diet based on cereal-derived foods and dairy products.
Even nowadays , in the medical field , more and more studies prove its efficiency as complementary therapy with no known side-effects.
Even nowadays the treatment of bladder cancer bears the highest lifetime treatment costs per patient among all forms of cancer.
Even older adults who lived in very walkable neighbourhoods walked to @number@ per cent fewer destinations in snow.
Even rarer are data from multiethnic populations.
Even recently , there have been no changes in the mortality of patients with severe gastric ulcers.
Even so , existing studies of callosal development tend to use parcellation schemes that may not capture the complex spatial profile of anatomical changes.
Even so , gender differences in the limit to frailty have not been reported.
Even so , higher levels of MQ were associated with higher physical function scores.
Even so , how deficits might scale up from the subcellular level to give rise to clinically evident age-related changes can be investigated.
Even so , little is known about the origin of deficit accumulation.
Even so , @number@.5T Brain Atrophy and Lesion Index scores are similar to those obtained by use of 3T images.
Even so , our finding that @number@ of our @number@ subjects developed PVT is sobering.
Even so , the FI did not exceed @number@ in any individual.
Even so , the international diagnosis criteria , based on clinical aspects , can establish a certain , probable or a possible diagnosis.
Even so , they want to initiate projects , are optimistic about the future and take an interest in clinical epidemiology research.
Even so , to be useful , mathematical modelling must be clinically coherent in addition to mathematically sound.
Even the definition is still unclear.
Even the regeneration of these organs with the help of stem cells could lead to a breach of the necessary interactions in complex systems.
Even the same mutation may be associated with varying disease progression.
Even the seemingly simple task of transporting a cup of coffee without spilling creates complex interaction forces that humans need to compensate for.
Even those who do not experience dementia or mild cognitive impairment may experience subtle cognitive changes associated with aging.
Even though anti-Gal-8 antibodies are not specific for MS , our results suggest that they could be a potential early severity biomarker in RRMS.
Even though broader concepts of frailty include psychological characteristics , frailty is largely neglected in mental health care.
Even though cellular senescence is a barrier for cancer it can , paradoxically , stimulate development of cancer via proinflammatory cytokines.
Even though declines in sensorimotor performance during healthy aging have been documented extensively , its underlying neural mechanisms remain unclear.
Even though ocular adverse effects are not very frequent , some of them can lead to permanent ocular dysfunction and visual impairment.
Even though particular WM regions did exhibit significant differences , these differences were on the same order as test-retest errors.
Even though strong connections have been highlighted between glycation and age-related pathogenesis , causal links still need to be validated.
Even though studies on the potential effects of bone on muscle metabolism are sparse , few osteokines have been identified.
Even though the factors that affect elderly suicide are complicated , there has been little research into these influencing factors.
Even though the impact is multi-faceted , a common theme of cost emerges.
Even though these sleep disturbances increase with advancing age , there are nevertheless inherent differences in sleep disturbances between males and females.
Even though the US population is aging , outcomes of VHR in the elderly and oldest-old ( ≥80 years ) are not well documented.
Even though , this group also reduced their stereotype score.
Event memory depends in part on segmenting ongoing activity into meaningful units.
Event rates adjusted for competing risks were obtained by microsimulation.
Even treatment that should remove soluble oligomers has not consistently reduced the load.
Event-related brain potentials ( ERPs ) were used to examine age differences in the neural correlates of proactive and reactive control for task-switching.
Event-related potentials ( ERPs ) elicited by identifiable novels were augmented compared to ERPs elicited by non-identifiable novels around 200ms after stimulus onset.
Event-related potentials ( ERPs ) were recorded to investigate age-related differences in the processes underlying AV speech perception.
Event-related potentials ( ERP ) were recorded while participants performed a word-stem cued-recall task.
Events often include novel combinations of items.
Events that were typical included tenderness , redness , and slight edema.
Eventually , @number@ participants in the intervention group and @number@ in the control group were included for data analysis.
Eventually , therapeutic implications for facial aging treatment will be addressed.
Eventually , this may contribute to the development of tailored prevention programs.
Eventually , this state of compensated failure cannot be sustained , and the ovary becomes unable to produce functioning follicles.
Eventually , VSMC plasticity and signaling in both conductance and resistance arteries are highly relevant to the physiology of normal and early vascular aging.
Even using histological techniques it is difficult to delineate with certainty from surrounding structures.
Even when AMH levels are very low , a spontaneous pregnancy may still occur.
Even when clinical sites had accessible equipment , this equipment was sometimes unavailable for the appointment.
Even when larger muscles are treated with higher doses of BoNT-A , the duration of effect is still shorter than that for smaller muscles.
Even when mtDNA haplogroups defined by C150T and gender were taken into account , there was no significant association with longevity.
Even when pregnancy termination is not elected , infants diagnosed prenatally receive less intense care.
Even when the delegation had expired , administration of medication continued , placing the statutes of regulation in a subordinate position.
Even with advancements in pre- and post-harvest food safety , Shiga toxin-producing Escherichia coli ( STEC ) still present challenges to human health.
Even with a pre / post survey design , our study could be subject to reverse causation and confounding bias.
Even with optimal care , the risk of mortality and morbidity remains high.
Even without significant aortic valve stenosis , aortic sclerosis is associated with a @percent@ increased risk of myocardial infarction and death from cardiovascular causes.
Even with RPA bound stoichiometrically to this gap , WRN efficiently catalyzed regression of the fork substrate.
Even with these age-related changes in abdominal fat distribution , women retained the subcutaneous-dominant type of fat distribution up to @number@ years.
Even with this pathogenic mutation , the proband lived to over @number@ years.
Everolimus-induced apoptosis of vascular ECs in response to radiation was also followed by thrombus formation that leads to tumor necrosis.
Everolimus with FR markedly reduced SAS and SAS-R tumor volumes.
Ever since , energy-based devices have been deployed to treat pelvic pathologies and improve fertility.
Ever since we developed mitochondria to generate ATP , eukaryotes required intimate mito-nuclear communication.
Ever smoking , hypertension , and an increased LDL-C / HDL-C ratio were significantly associated with an increased likelihood of increased cIMT.
Every 90minutes REM sleep recurs , with muscle atonia and rapid eye movements.
Every additional year of experience by the top executive was associated with a @percent@ increase in the odds of having a succession plan.
Every aerobic organism is inevitably exposed to a permanent flux of free radicals and oxidants.
Every anatomic component of the midface is affected.
Every cycle of treatment was followed by one month of wash-out.
Everyday activities break down into parts and subparts , and appreciating this hierarchical structure is an important component of understanding.
Everyday consumer choices frequently involve memory , as when we retrieve information about consumer products when making purchasing decisions.
Everyday life benefits from cochlear implantation were also evaluated.
Everyday PM was assessed in young and older adults using a diary approach.
Everyday walking is often interrupted by obstacles and changes in the environment that make gait a highly non-stationary process.
Every day we use our eyes to perform activities of daily living and work.
Every disturbance of this balance constitutes a clear and present danger to the macromolecular integrity of the body.
Every effort should thus be made to support smoking cessation.
Every facet of neurotransmission , from dendritic spine to exocytotic machinery , is in play , and defects of synaptic inhibition are over-represented.
Every general practitioner ( GP ) will have patients who have had refugee-like experiences.
Every hip fracture begins with a microscopic crack , which enlarges explosively over microseconds.
Every @number@ days more or less the earth rotates , revolves , wobbles , and precesses along an elliptical path around the sun.
Every @number@ days , subjects completed a cycling TTE at @percent@ VO2max , and TWC was calculated.
Every @number@ months , participants completed the American Alliance for Health , Physical Education , Recreation and Dance standardized tests.
Every @number@ steps taken was associated with lower rate of MMD ( @percent@ ) and PMMD ( @percent@ ) .
Every @number@ years , the EHC circulates a survey to its national member organizations to assess the state of haemophilia care.
Everyone is bacteriuric.
Every participant was under monitoring for the morbidity of HDP and the high-risk factors were investigated in HDP cases in each group.
Every second person was unmarried.
Every study was evaluated using the Jadad scale.
Every validated fresh fracture patient with DTT , DOT , and outcome is reported.
Every woman had a face-to-face interview.
Every year , an estimated 30-40% of patients over the age of @number@ will fall at least once.
Every year , more and more patients fall into rare or extreme categories of breast cancer-young , elderly , pregnant , or male.
Evidence about phase @number@ ( performance in real world ) and phase @number@ ( quantify impact and costs ) is yet to come.
Evidence about the association of educational attainment and the onset of terminal decline is scarce.
EVIDENCE ACQUISITION : Cancer mortality data were derived from global vital registries.
EVIDENCE ACQUISITION : Medline was searched for the period ending @date@ and included studies on human and animal tissues and animal models.
EVIDENCE ACQUISITION : The mechanisms discussed in this review are based on a PubMed search and knowledge of the authors in the field.
EVIDENCE ACQUISITION : The medical literature from @number@ to @date@ was reviewed for key articles.
EVIDENCE ACQUISITION : We conducted a systematic review of the published literature for elderly patients that underwent spinal fusion surgery with the use of rhBMP-2.
EVIDENCE ACQUISITION : We performed a critical review of the published abstract and presentation literature on combined modality therapy for muscle-invasive bladder cancer.
EVIDENCE ACQUISITION : We searched PubMed for English-language articles in peer-reviewed journals and the Cochrane Library database from inception through @date@ .
Evidence also indicates deficits in working and prospective memory , with inconsistent evidence about impairments of the former.
Evidence also points to a biological role for BACE1 in axonal outgrowth and synapse formation during development.
Evidence-based approaches to the recruitment and retention of diverse elders are explored.
Evidence-based data for the management of anticoagulation in elderly patients with severe renal impairment , in particular , are limited.
Evidence-based interventions targeted to these health determinants are suggested.
Evidence based management strategies for treatment of age-related hair changes are also reviewed.
Evidence based on the cognitive aging literature supports a number of factors associated with cognitive functioning.
Evidence-based practice for the elderly patient is difficult because elderly patients , especially the frail , are often excluded from clinical trials.
Evidence based recommendations are available to assist GPs in the diagnosis and ongoing management of people with dementia.
Evidence-based recommendations for interventions to reduce fall risk in older adults with visual impairment are lacking.
Evidence-based results on physiological and hormonal changes will also be reviewed.
Evidence-based strategies to prevent diabetes in midlife women are highlighted.
Evidence-based therapies ( EBTs ) for the prevention of cardiovascular disease ( CVD ) are reportedly underutilized in older people.
Evidence demonstrates that when these principles are adhered to , muscle maintenance or hypertrophy over prolonged periods can be further augmented in active older persons.
Evidence for a benefit of vitamin D supplementation alone on reducing fracture risk is varied.
Evidence for a maternally inherited , maternal age-related mechanism provides further insight on risk factors and genetic transmission in late-onset AD.
Evidence for amyloid alone is not sufficient to indicate risk of rapid cognitive decline in healthy elderly.
Evidence for cholinergic dysfunction in very early stages of neurodegeneration like mild cognitive impairment ( MCI ) is inconclusive.
Evidence for divergent and convergent validity is provided.
Evidence for FOF , FSe , and BC predicting AL was tentative as was evidence to suggest FOF predicted coping.
Evidence for health system interventions on ageing populations is very limited , particularly for low- and middle-income settings.
Evidence for its psychometric properties may support GAS as goal-setting instrument and additional outcome measure.
Evidence for spared musical memories in aging and AD is reviewed here.
Evidence for the beneficial effects of consuming a walnut-rich diet is reviewed in this article.
Evidence for the construct validity of CANE was found in terms of significant associations between CANE and other instruments or scores.
Evidence for the effect of cataract on frailty and frailty outcomes after restoring vision by cataract surgery remains limited.
Evidence for the health-promoting effects of food rich in n-3 polyunsaturated fatty acids ( n-3 PUFA ) is reviewed.
Evidence for the use of adjuvant chemotherapy and trastuzumab for high-risk disease in the elderly is more limited.
Evidence for this hypothesis is mixed though different methodologies have made these findings difficult to interpret.
EVIDENCE FOR VACCINE EFFECTIVENESS WAS SOUGHT FROM : ( @number@ ) Studies of regions with increasing vaccination rates.
Evidence from animal models and preliminary studies in humans indicates that calorie restriction ( CR ) delays cardiac aging and can prevent cardiovascular disease.
Evidence from animal studies and human famines suggests that starvation may affect the health of the progeny of famished individuals.
Evidence from animal studies suggests that these two neurotransmitters may interact in influencing memory performance.
Evidence from ASCOT shows that antihypertensive and vascular effects of amlodipine with and without perindopril have translated into real-life clinical benefits.
Evidence from both epidemiological and biological studies support the concept of metabolic osteoarthritis , defined as a broad clinical phenotype that includes obesity-related osteoarthritis.
Evidence from five observational cohort studies of @number@ patients ( @percent@ male ) with CV disease indicates that CRF significantly alters the obesity paradox.
Evidence from large randomized controlled trials will be needed before conclusions can be drawn.
Evidence from neuroimaging studies suggests a critical role of hippocampus and inferior frontal gyrus ( IFG ) in associative relative to item encoding.
Evidence from @number@ studies were synthesized in @number@ different intervention categories : multi-component , exercise , medication and other interventions.
Evidence from perceptually based implicit memory tasks demonstrates greater priming from distracting information among older compared with younger adults.
Evidence from randomized controlled trials and large systematic reviews and meta-analyses suggested that the healthcare setting may modify the effectiveness of CGA programs.
Evidence from these studies is considered against study design , methodological issues and in the context of the current understanding of frailty.
Evidence grows that the syndrome is linked to several important health outcomes.
Evidence has been adduced for a variety of physiological effects , including anti-aging , anti-cancer , anti-gastritis , and anti-metabolic disease properties.
Evidence has been developed for oxidative and nitrative damage to key cellular components in the PD substantia nigra.
Evidence has begun to emerge for microRNAs as regulators of synaptic signaling , specifically acting to control postsynaptic responsiveness during synaptic transmission.
Evidence has emerged that antidiabetic biguanides and rapamycin are promising candidates for pharmacological interventions leading to both life span extension and prevention of cancer.
Evidence has emerged that antidiabetic drugs are promising candidates for both life span extension and prevention of cancer.
Evidence has suggested that APE1 missense mutants , as well as altered expression or localization of the protein , can contribute to disease manifestation.
Evidence indicates that HNE modified lipoic acid is cleaved from KGDH , potentially the first step of a repair process.
Evidence indicates that only the amyloidogenic pathway generates AICD capable of nuclear signaling , due to the subcellular compartmentalization of APP processing.
Evidence indicates that the pathophysiologic mechanisms associated with insulin resistance may contribute to cognitive aging and Alzheimer's diseases.
Evidence in support of the cognitive effects of epigenetics-diet , and nutraceuticals is reviewed.
Evidence is accumulating on the effects of subjective aging-that is , how individuals perceive their own aging process-on health and survival in later life.
Evidence is also emerging about the negative impact of these chemical exposures on mental health , including depression , suicide , and other risks.
Evidence is also mounting that dietary advanced glycation end products ( AGEs ) are important risk factors for AD.
Evidence is available on simplification strategies with boosted protease inhibitor monotherapy aiming to avoid or reduce potential or demonstrated toxicity.
Evidence is conflicting with regard to occult stress urinary incontinence.
Evidence is emerging that autophagy plays a key role in the degradation of damaged cellular components and thereby affects aging and lifespan control.
Evidence is emerging that lncRNAs influence the molecular processes that underlie age-associated phenotypes.
Evidence is given to the daytime predictors of early symptoms of SDB , important indicators for the proper time to initiate mechanical ventilation.
Evidence is growing linking precursors of amyloid deposition in the brain and pancreas to the pathogenesis of AD and T2DM , respectively.
Evidence is lacking about the effect of thyroid hormone treatment.
Evidence is mounting to indicate that the dose response curve is shifted according to the relative expression of ERα and ERβ.
Evidence is outlined supporting the concept of aluminum's involvement in hastening brain aging.
Evidence is presented suggesting that antioxidants and anti-inflammatories can reduce the pace of shortening of telomere length during aging.
Evidence , largely accrued from small-scale studies involving select populations , suggests that stress may promote non-clinical reactivation of this virus.
Evidence Level II studies show longevity of @number@ months or more after nasolabial fold implantation.
Evidence of an increasing rate of intracerebral hemorrhage among the elderly with acute ischemic stroke , following alteplase treatment , has not been reported.
Evidence of convergent , discriminant and known groups validity for the DEMMI were obtained.
Evidence of directional pleiotropy averaged across all variants was sought using MR-Egger regression.
Evidence of disordered thresholds and poor model fit were found both in the MAL and LF-MAL.
Evidence of efficacy for deprescribing is emerging from randomized trials and observational studies.
Evidence of immune stimulation has been noted in opiate dependent patients for many decades.
Evidence of immunodeficiency ( Evans syndrome and selective IgA deficiency ) was observed in a single case.
Evidence of increased inflammation was demonstrated by an increase in CRP and ESR ( P ≤ @number@ THR and TKR ) .
Evidence of inner-retinal lesions and damage have been documented ophthalmoscopically , however their long term structural effect has not been investigated.
Evidence of low quality demonstrates that QoL is worse with IFN alone and that severe AEs are increased with IFN alone or in combination.
Evidence of perinatal programming of adult mortality raises the question of what mechanisms embed this long-term effect.
Evidence of powerful individual differences in cognitive aging has sharpened focus on identifying biological factors underlying relative preservation versus vulnerability to decline.
Evidence of region-specific rates of microstructural development was observed.
Evidence of the accuracy of influenza morbidity and mortality estimates was sought from : ( @number@ ) Studies comparing statistical models.
Evidence of the benefits of BP telemonitoring on these secondary outcomes is less robust.
Evidence of third molars in the elders is limited.
Evidence on its association with mortality in general population is scarce and conflicting.
Evidence on the mediating role of cognitive function was limited.
Evidence on the pharmacotherapy of late-life major depressive disorder ( LLD ) is scant.
Evidence on the positive role of moderate alcohol consumption on heart and metabolic diseases as well on reducing steatosis have been looked up.
Evidence points to the need to increase the level of consultation and inclusivity of older people on this topic.
Evidence presented here shows DHA acts to oppose this , exerting a plethora of pleiotropic activities to protect against the pathogenesis of Alzheimer's disease.
EVIDENCE : PubMed , the bibliography from the Evidence-Based PCOS Workshop , and the reference lists from identified manuscripts were reviewed.
Evidence regarding pneumonia was limited , although did not impact on mortality.
Evidence Review : A literature search of PubMed , Embase , the Cochrane Library , CINAHL , and Scopus was conducted in @date@ .
EVIDENCE REVIEW : A Medline search of scientific literature was conducted , with an emphasis on @number@ to the present.
EVIDENCE REVIEW : MEDLINE was searched from @number@ to @number@
Evidences are mounting that both SIRT1 and AMPK play important roles in cell fate determination of MSCs.
Evidences are sparse and quite controversial with only a few studies performed in older subjects.
Evidence shows a consistent trend toward footwear interventions markedly improving lateral stability measures , which are predictors of falls in the elderly.
Evidence shows population ageing to be historically a product of economic development , closely associated with high living standards and national affluence.
Evidence shows that aging is closely related to mitochondrial decay and redox imbalance.
Evidence shows that both HIV infection per se and HIV-related chronic immune activation despite antiretroviral therapy are critical factors linking MetS and cardiovascular complications.
Evidence shows that loss of myofibers may be , in part , due to apoptosis.
Evidence shows that physical activity and physical exercise positively influence cortical activities related to cognitive functions , as indicated by P300 , in elderly people.
Evidence suggests circulating uncarboxylated MGP ( ucMGP ) is elevated in persons with disease characterized by vascular calcification.
Evidence suggests many tools do not have cutoff scores linked with on-road outcomes , although some had stronger evidence than others.
Evidence suggests that AD evolves through distinct patterns of WM disruption , in which retrogenesis or , alternatively , the Wallerian degeneration may prevail.
Evidence suggests that Allium extracts have anti-cancer properties.
Evidence suggests that anthocyanins inhibit EGFR and Akt activity.
Evidence suggests that brief mitochondrial permeability transition pore ( mPTP ) openings play an important physiological role maintaining healthy mitochondria homeostasis.
Evidence suggests that , despite clear guidelines , symptoms of osteoarthritis generally remain poorly managed.
Evidence suggests that good support can improve caregiver psychological outcomes.
Evidence suggests that healthy adults with elevated cortical Aβ show differences in neural activity associated with memory encoding-specifically encoding of face stimuli.
Evidence suggests that it can be reactivated in several cancers worsening the prognosis.
Evidence suggests that mitochondria undergo functional and morphological changes with age.
Evidence suggests that multiple pathways may play a role.
Evidence suggests that musicians , compared to non-musicians , experience less age-related decline in auditory processing abilities.
Evidence suggests that poor muscle mass is associated with greater arterial stiffness and cardiovascular risk.
Evidence suggests that psychological and behavioral factors , including depressive symptoms and sleep , can alter endogenous pain facilitatory processes.
Evidence suggests that PTSD in the elderly does not follow a simple clinical trajectory.
Evidence suggests that the body uses autoantibodies to prevent disease and to self-treat diseases once started.
Evidence suggests that there are aging-related changes in corticospinal stimulus-response curve characteristics in later life.
Evidence suggests that the relationship between blood pressure and dementia risk varies between younger and older samples within the elderly population.
Evidence suggests that these age-associated perturbations in chromatin structure contribute to the age-associated increase in incidence of cancer.
Evidence suggest that in-home CGA might be most effective in elderly that have a relatively high level of functioning.
Evidence supporting an association between higher protein and / or thiamine intakes and better cognitive function is weak.
Evidence supporting germline mediated epigenetic inheritance of environmentally induced traits has increasingly emerged over the past several years.
Evidence supporting this hypothesis is presented in this review.
Evidence supports the use of gait as a biomarker of disease and to complement diagnosis and inform disease management.
Evidence supports treatment of social communication problems in a group format.
EVIDENCE SYNTHESIS : In @number@ @number@ million kidney , bladder , and prostate cancers cases occurred worldwide , increasing @number@.5-fold since @number@
EVIDENCE SYNTHESIS : The current data suggest that daughters of women with PCOS have a greater follicle complement and mild metabolic abnormalities from infancy.
Evidence Synthesis : The results are presented in systematic tables.
EVIDENCE SYNTHESIS : Twenty-five papers were identified that met our inclusion criteria.
Evidence that aerobic fitness is associated with accelerated cognitive decline emphasizes the possible importance of behavioral interventions to optimize cognitive aging over time.
Evidence that depressive symptoms are inversely related to n-3 ( ω-3 ) fatty acids is growing among United States adults.
Evidence that these changes correlate with poorer cognitive and functional outcomes corroborates this progressive characterization of chronic TBI.
Evidence that these interventions reduce total costs is inconclusive.
Evidence that the use of memantine in a patient already on cholinesterase inhibitor therapy can provide a clinically significant benefit is limited.
Evidence that this mechanism can also lead to protein-protein crosslinks within cells is provided where five crosslinked peptides were detected in a human cataractous lens.
Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene expression.
Evidence was found that chronic endurance exercise training programs can attenuate systemic inflammation in patients with chronic heart failure and type @number@ diabetes mellitus.
Evidently population studied differed on concentration of genes responsible for significant LS and SR differences.
Evidently , the implementation of spiritual-care education must continue apace and careful consideration be given to optimizing its acceptance by the establishment.
Evocative of its ancestor , yeast Sir2 , SIRT6 has the ability to increase lifespan in mice.
Evoking the framework of the ( TWIN ) model , an explicit expression for optimal window width is obtained.
Evol.
Evolutionarily conserved responses and maintenance mechanisms such as FOXO are impaired in AD.
Evolutionary Algorithms constitute a family of search algorithms which base their operation on an analogy from the evolution of species in nature.
Evolutionary biology should become a foundational science for the medical education of the future.
Evolutionary , molecular , cellular and systemic theories have been postulated to explain the primary disease independent age-related changes and adaptive responses.
Evolutionary opportunities include adjustments of individual functions , multitasking , connection between various components of an organism , and interaction between organisms.
Evolutionary origins of CGIs are also highly heterogeneous.
Evolutionary processes of natural selection may be expected to leave their mark on age patterns of survival and reproduction.
Evolutionary reasoning first articulated by G. Williams suggests that multiple , redundant clocks might influence organismal aging.
Evolutionary reasoning first articulated by G. Williams suggests that multiple , redundant clocks might influence organismal aging.
Evolutionary theories of aging posit that greater reproductive effort causes somatic decline given a fundamental trade-off between investing energy in reproduction and repair.
Evolutionary theories of aging predict a trade-off between fertility and lifespan , where increased lifespan comes at the cost of reduced fertility.
Evolutionary theory predicts that aging-related fertility declines result from tradeoffs between reproduction and somatic maintenance.
Evolutionary theory predicts that early-life investment in reproduction should be favoured by selection at the cost of reduced survival and faster reproductive senescence.
Evolutionary theory suggests that optimal virulence might increase if the mortality of the host ( from unrelated causes ) increases.
Evolution favors early and efficient reproduction , but does not care for longevity.
Evolution has fine-tuned proteins to accomplish a variety of tasks.
Evolution , phylogeny and ontogeny include spontaneous and non-spontaneous processes.
EVs are also increasingly recognized as having a direct role in pathologies such as cancer and neurodegeneration.
EVs transport cellular materials in many physiologic processes , including differentiation , stem cell homeostasis , immune responses , and neuronal signaling.
EWAS studies should investigate the role of this interindividual variation in DNA methylation , in the age-associated diseases of sarcopenia and dementia.
E wave and e ' were higher in younger subjects and decreased progressively in the older ones.
EWSAT1 over-expression facilitated , while EWSAT1 silencing impaired cell growth in NPC.
Exacerbating factors include volume and sodium indiscretion , arrhythmias , ischemia , and comorbidities.
Exacerbations are marked by an increase from baseline in dyspnoea , sputum volume and sputum purulence.
Exacerbations of COPD increase rates of hospitalization and mortality and decrease quality of life.
Exact ages were used for calculations of maximum length of life.
Exact epileptic spasm time , EEG localization , and the presence or absence of magnetic resonance imaging lesion were also recorded.
Exact etiology of these benefits should be determined for quality improvement in care of the injured geriatric patient.
Exactly how rapamycin works to extend lifespan is under increasingly intense investigation.
Exactly how the contractile function of the detrusor muscle changes with ageing is unclear.
Examination algorithm was developed that allows selective estimation of acoustic density of different lens zones and biometric measurements including volumetric.
Examination included echocardiography , triplex ultrasound of brachiocephalic arteries , bifunctional 24-hour blood pressure ( BP ) monitoring with assessment of arterial stiffness.
Examination of control human donor specimens and mice demonstrated an age-related increase in autophagosome numbers and expression of autophagy proteins.
Examination of cyclin-dependent kinase inhibitors revealed the involvement of p15 ( INK4b ) and p27 ( KIP1 ) .
Examination of interaction terms indicated some sex differences in the association between cultural factors and caregiving in the Northern Plains but not in the Southwest.
Examination of predicted amino acid changes revealed a skew towards pathogenic SNVs in the coding region driven by mutation bias.
Examination of scale dimensions using older and new items was completed using a forward-entry stepwise regression.
Examination of splicing patterns at specific loci was examined in a second cohort , the Exeter @number@ study.
Examination of these mechanisms is a critical need to direct appropriate treatment.
Examination of turning behavior showed that all participants veered to the right.
Examinations consisted of ocular examination with lens photography and grading ; medical history ; and measurements of blood pressure , height , and weight.
Examination surveys were conducted every @number@ years in @number@ and @number@
Examinations were made by light and electron microscopy using special stains.
Examine body composition changes across the lifespan of HIV-infected compared to uninfected adults.
Examining a population's unique DNA methylation pattern allows us to differentiate hallmarks of longevity from individual stochastic variation.
Examining multiple life factors across long time periods uncovers important pathways through which personality relates to premature mortality or longevity.
Examples are illustrated in each case , while open issues and challenges for further research and development are pinpointed.
Examples are osteoporosis , osteomalacia , osteogenesis imperfecta ( OI ) , and osteopetrosis in both humans and animal models.
Examples from multiple ischemic lesions caused by different disease processes affecting the cerebral arteries are presented for comparison.
Examples from our work in the aging rodent brain as well as other aging models are provided.
Examples of changes in DNA methylation and histone modification occurring in synovial fibroblasts during the disease process are reviewed in this chapter.
Examples of conditions and diseases that are highlighted in this review include the metabolic syndrome with its co-morbidities , immune-related diseases and HIV.
Examples of current research showing the utility of these markers are reviewed.
Examples of each challenge are described with strategies that we used to manage the challenge.
Examples of interventions directed by advanced practice nurses are described.
Examples of potential arrestive therapies include gene-related treatment modalities to inhibit intraocular neovascularization and to block retinal cell apoptosis.
Examples of practice efforts actualized using this research are also presented.
Examples of research from Brazil and Portugal are reviewed and discussed.
Examples of specific types of dementia include Alzheimer disease , vascular dementia , frontotemporal dementia and dementia with Lewy bodies.
Examples of the possible functional role of some of these genes ( e.g. transthyretin , quinone reductase @number@ ) and gene products are discussed.
Examples supporting the validity of these conclusions are provided.
Excellent anatomical detail can be observed with @number@.0-Tesla MRI.
Excellent correlations were obtained for inhibition kinetics in vitro of mouse brain enzymes vs. hen brain and human recombinant enzymes.
Except B-Cd , all toxic elements showed exceeded blood levels.
Except for age , both groups had comparable demographic features , disease characteristics , and prognostic factors.
Except for calcium intake , no positive intervention effect was observed for any of the other outcomes.
Except for cardiac diseases , the effect of the analyzed comorbidities on ADL performance was not significant.
Except for causes correlated with heredity , aging and life habits , environmental role is worth taking into consideration as well.
Except for end-stage renal disease ( ESRD ) , Whites tended to have the highest rates of prevalent diabetic complications.
Except for extrinsically activated clot strength and lysis , parameters for ROTEM assays were significantly different among all age groups.
Except for female HC , all the other anthropometric indices were significantly correlated with BPS.
Except for hemoglobin status , no significant differences between genders were detected.
Except for higher ASCA IgG in subjects < 18 years , antibody levels were not age-dependent.
Except for methods of inducing hypotension , TEVAR was performed according to the same protocol in each group.
Except for RPS , these volumes were also significantly lower than HPSV during slow injections.
Except for SB , E values did not change after water-storage , but they increased after storage in oil.
Except for smoking , the causative contribution of these variables to mortality was deemed inconclusive.
Except for uCTX , the BTM reference value determined using a curve-fitting valley was significantly lower than the reference values for premenopausal women.
Except for volume , characteristics of semen such as motility , concentration , and morphology did not decrease with age.
Except for waist circumference in women , no other traditional cardiovascular risk factors predicted longitudinal PWV increase.
Except for working memory , no significant interactions were found between the age groups and the study group ( depressed / healthy ) .
Except in people with Down syndrome , primary ageing occurs at a normal age in this population.
Exceptional aging was also associated with obesity rates and median income.
\ "Exceptional aging \ " without ADP may be possible with a greater number of protective factors across the lifespan but warrants further investigation.
Exceptionally long-lived people may be enriched for genes that contribute to their longevity , some of which may bear on immune function.
Exceptions may be for those individuals with impaired renal function.
Exceptions with higher survival in Germany were cancers of the stomach , pancreas and kidney and Hodgkin's lymphoma.
Excess activity of antioxidant enzymes and an insufficient amount of low molecular weight antioxidants indicate new pharmacological strategies for patients suffering from the aforementioned diseases.
Excess body fat , accumulated through aging and / or a calorie-rich diet , is associated with many chronic metabolic and inflammatory diseases.
Excess cortisol levels are linked with brain atrophy and cognitive decline in older people.
Excess health costs in the @number@ years around diagnosing and treating TB were € @number@
Excess intracellular accumulation of this adduct in RPE cells in vitro leads to a significant loss of cell viability and caused membrane damage.
Excessive accumulation of its precursor prelamin A or the mutant form called ' progerin ' causes premature aging syndromes.
Excessive accumulation of reactive oxygen species was not observed in the cytosol or mitochondria of untreated LB25.
Excessive eryptosis , however , may lead to anemia and may interfere with microcirculation.
Excessive erythrocytosis results in severely increased blood viscosity that may compromise the vascular endothelium.
Excessive inflammation is a major cause of organ damage during sepsis.
Excessive intake of almost all the micromutrients , particularly for a long period of time , produces adverse effects.
Excessive intracranial pulsatility is thought to damage the cerebral microcirculation , causing cognitive decline in elderly individuals.
Excessively elevated resting metabolic rate ( RMR ) for persons of a certain age , sex , and body composition is a mortality risk factor.
Excessive muscular coactivation reduces the performance of agonist muscles.
Excessive nitrosative and oxidative stress is thought to trigger cellular signaling pathways leading to neurodegenerative conditions.
Excessive reactive oxygen species ( ROS ) induce apoptosis and are associated with various diseases and with aging.
Excessive RELN promoter methylation and / or decreased RELN gene expression have been described in schizophrenia and autism.
Excessive wall circumferential stress in arteries caused by luminal pressure leads to endothelial damage and clinical consequences.
Excessive weight gain in adulthood might be particularly detrimental to the health of old individuals with low birth weight.
Excessive workload , aging and discouragement of staff and patients ' social problems have negative effects.
Excess medical costs resulting from HI ranged from $ 3.3 to $ 12.8 billion in the United States.
Excess of advantageous gene variants seems to be of more importance for longevity than absence of known disease-sus-ceptibility genes.
Excess of bone remodeling is still the major pathogenic factor in involutional osteoporosis.
Excess of glucocorticoids ( GCs ) has been reported to lead to skin atrophy and impaired wound healing.
Excess or insufficient glucocorticoids cause myriad abnormalities from development to ageing.
Excised orbital fat was then grafted under the released tear trough ligament to correct the tear trough deformity.
Excision of the mass with dural repair , craniofacial reconstruction , and medial canthopexy were done for all patients.
Excitability indices measured in the sensory axons of both nerves were not overtly different.
Excitatory and inhibitory balance of neuronal network activity is essential for normal brain function and may be of particular importance to memory.
Exciting new work on autophagy-modulating proteins that are enriched at the synapse has begun to link autophagy to synapses and synaptic dysfunction in disease.
Exciting recent evidence indicates that calretinin-expressing interneurons are added to the adult human striatum at a substantial rate.
Excluded were postoperative , critical care , and nursing home studies.
Excluded were subjects with facial spastic disorders , injection after upper face lifting , and aberrant regeneration of facial nerves.
Excluded were those admitted directly to the intensive care unit ; obstetric , psychiatry , or palliative wards ; or medical day units.
Excluding health and job stresses , the impact generally decreased with aging.
Excluding @number@ patients who died at @date@ @percent@ of patients had a recurrence over the study period.
Excluding patients with prevalent cardiovascular disease revealed very similar results.
Excluding tumor size and grade , no statictically significant difference was found between the two groups according to histopathological characteristics.
Exclusion criteria comprised factors potentially influencing spinal mobility.
Exclusion criteria consisted of a prior severe adverse event from AChEIs.
Exclusion criteria included glaucoma , retinal diseases , diabetes , history of prior intraocular surgery or laser treatment.
Exclusion criteria included physical illness , medication use , obesity , alcohol or substance abuse , and pregnancy.
Exclusion criteria included prior surgery , plucked eyebrows , and botulinum toxin.
EXCLUSION CRITERIA : psychiatric disorders.
Exclusion criteria were any special diet , diabetes mellitus , any known gastrointestinal disease or prior gastrointestinal surgery.
Exclusion criteria were a performance status of @number@ or @number@ and the ability to urinate after standard placement of the stent.
Exclusion criteria were decompensated CHF , malignancy and end-stage renal disease.
Exclusion criteria were hip surgery , fracture , infection , tumor , or inadequate image quality.
Exclusion criteria were lack of focus on an intervention and focus on informal caregivers.
Exclusion criteria were suspected or evident pregnancy , no cellulite , no informed consent or age under @number@ years or above @number@ years.
Exclusion : Nursing home residents and patients with terminal illnesses or cognitive impairment.
Exclusion of anemic participants did not affect the overall findings.
Exclusion of deaths during the first year and cancer deaths had minimal effects on these results.
EXCLUSIONS : known cardiovascular disease or therapy or acute exposure to alcohol , amphetamine , heroin or methadone.
Executive cognitive functions play a critical role in falls risk a pressing health care issue in seniors.
Executive directors supported interprofessional practice of nurses working with dental hygienists to optimize oral health care of residents.
Executive dysfunction can be assessed with cognitive tests and subjective report of difficulties with executive skills.
Executive dysfunction is also considered a predictor of adverse health events in the elderly.
Executive dysfunction is frequently associated with episodic memory decline in amnestic mild cognitive impairment ( aMCI ) patients.
Executive function , depressive symptoms , and symptoms of GAD were assessed using established measures and scoring procedures.
Executive function ( EF ) and cognitive processing speed ( CPS ) are two cognitive performance domains that decline with advanced age.
Executive function ( EF ) deficits are a core symptom of PDD.
Executive function impairment was present regardless of age and education.
Executive functioning accounted for additional variance in a broad range of daily living skills after controlling for IQ decline.
Executive functioning and global cognitive functioning also deteriorated.
Executive functioning correlated with magnitude of increases in right primary motor cortex ( BA4 ) during the motor imagery task.
Executive functions also change in normal elderly.
Executive functions , episodic memory , visuospatial function , word fluency , processing speed and global cognitive function were examined for exercise- and sex-dependent effects.
Executive functions regressed positively on LPA and Cognitive activity , but negatively on job-related PA ( JPA ) .
Executive functions showed the strongest and persistent differences between the most recent and other three cohorts.
Executive functions were also evaluated by the Wisconsin Card Sorting Test.
Executive function was assessed with Trail-Making Test ( TMT ) A and B before and after passive leg cycling.
Executive function was measured separately from the stress tasks by using five neuropsychological tests.
Executive function was measured with the TMT-B and Stroop-Interference measures.
Executive impairment is prominent in schizophrenia , in conditions such as Parkinson's disease and dementia and in healthy aging.
Exemplarily , we monitored induction of DNA damage and repair processes in human induced pluripotent stem cells and isogenic fibroblasts.
Exemplar photos and reflections are provided.
Exemplars were identified to provide a representation of the attributes in context , and a model of disability and aging was created.
Exemplary scientific methods describe concepts and provide theories for further testing.
Exenatide decreased p-NF-κB and increased p-AMPKα levels in human CVSMCs @number@ h after treatment.
Exenatide decreased the expression of RANKL in a dose-dependent manner.
Exercise above this threshold stimulates adaptations towards maximising athletic performance , but is unlikely to have further beneficial effects on health.
Exercise alone or as part of physical therapy management is often recommended as a non-pharmacological intervention.
Exercise also exerts its protective effects against cardiac aging and cardiac metabolic derangement.
Exercise and hypoxia paradoxically modulate vascular thrombotic risks.
Exercise and sports activities can afford mechanical stimuli to the bone and joint tissues which are required to maintain the tissue properties.
Exercise and the APOE genotype were also assessed at baseline.
Exercise-associated DNA methylation change was stronger among older people ( ie , age accounted for @percent@ of the variation ) .
Exercise-associated DNA methylation modification could rewind the ' epigenetic clock ' as we age.
Exercise-associated effect sizes were calculated by gene.
Exercise attendance rate was high ( @percent@ ) .
Exercise at this intensity was not harmful and did not increase risk factors for diseases associated with oxidative stress in the participants of the study.
Exercise before protein-rich meals improves skeletal muscle protein anabolism.
Exercise beliefs are one of the key predictors of exercise behavior.
Exercise bouts were separated by @number@ min of recovery.
Exercise can alter the balance of oxidative and anti-oxidative species within the human body and may cause oxidative damage to lipoproteins.
Exercise can effectively and efficiently reduce falls.
Exercise causes hypertrophy of NMJs and improves recovery from peripheral nerve injuries , whereas decreased physical activity causes degenerative changes in NMJs.
Exercise consisted of intermittent walking to near maximal claudication pain for @number@ months.
Exercise decreases fat and maintains muscle mass ; however , older people fail to exercise at doses sufficient to affect musculoskeletal and cardiometabolic risk factors.
Exercise differentially modulated respiratory complexes.
Exercise dose was computed using Vo2 / heart-rate derived linear regression equations.
Exercise habit in middle age was associated with low prevalence of sarcopenia in older age.
Exercise has been shown to counter weight gain ; however , it might increase circulating androgens.
Exercise has been shown to improve physical function , though response to exercise is variable.
Exercise has beneficial effects on the nervous system , including at the neuromuscular junction ( NMJ ) .
Exercise improves blood sugar regulation , and resistance exercise increases or maintains muscle mass and is associated with improved cognitive function.
Exercise including muscle strength and spinal ROM may be able to influence these primary factors related to QOL.
Exercise-induced increases in reactive oxygen and nitrogen species promote an acute redox-regulated stress response that manifests as increased heat shock protein and antioxidant enzyme content.
Exercise-induced skeletal muscle hypertrophy occurred independent of age , whereas the improvement in VO2peak was more pronounced in young men.
Exercise induces changes in the immune system depending on its intensity and duration.
Exercise in humans , on the contrary , is the key event to countermeasure sarcopenia.
Exercise in the elderly needs to be carefully tailored and individualized with the specific objectives of the person or group in mind.
Exercise is an effective non-pharmacological intervention that can reduce pain and improve physical and psychological functions.
Exercise is a non-pharmacological strategy to mitigate the deleterious effects of aging on brain health.
Exercise is a nonpharmacological treatment shown to benefit all patients with hypertension.
Exercise is a self-management approach that can promote health for people aging with HIV.
Exercise is a uniquely effective and pluripotent medicine against several noncommunicable diseases of westernised lifestyles , including protection against neurodegenerative disorders.
Exercise is considered to be a safe medicine to attenuate inflammation and cellular senescence.
Exercise is linked with the type / intensity-dependent adaptive immune responses , whereas hypoxic stress facilitates the programmed death of CD4 lymphocytes.
Exercise is universally recognized as a key feature for maintaining good health.
Exercise may be considered a safe and beneficial for enhancing the health of medically stable adults aging with HIV.
Exercise may possibly stimulate mitochondrial biogenesis and phase II antioxidant defense system to regulate mitochondrial function and balance of redox system.
Exercise may reduce stress and agitation.
Exercise mode and intensity / duration are important factors for influencing muscle morphology and function as well as bone.
Exercise of intensity greater than @number@ MET-min / week was significantly associated with higher lean and bone masses and lower fat mass.
Exercise ( past or current ) also influenced BMD.
Exercise performance falls with age , with a small decrease in arterial oxygenation that stabilizes over the age of @number@ years.
Exercise prescriptions for older adults should account for the individual's health status and functional capacity.
Exercise prescription started at @number@ min ( @number@ min / week up to @number@ min ) based on participant's maximal aerobic power.
Exercise programs can be evaluated on a second radiographic study 3-4 weeks later.
Exercise programs may be helpful , but their immediate effects cannot be examined during the initial modified barium swallow.
Exercise programs that are structured , individualized , higher intensity , longer duration , and multicomponent show promise for preserving cognitive performance in older adults.
Exercise resulted in reductions in HRV such that multiple measures of HRV were not significantly different between age groups during the afternoon and evening periods.
Exercise seems to improve insulin resistance through mitochondrial function by activating AMP-activated protein kinase ( AMPK ) and PPARgamma coactivator-1alpha ( PGC-1alpha ) .
Exercise self-efficacy improved among those adhering more to circuit training or support group meetings.
Exercise sessions were supervised by a certified exercise trainer three times per week.
Exercise , the best way to recover muscle mass , is not always applicable.
Exercise tolerance was assessed by knee extensor exercise ( KE ) time to fatigue.
Exercise training alone is not always effective to improve PWV and lean mass ( LM ) in older women.
Exercise training also improved resting HR and recovery HR in YG and EMG ( P < 0.05 ) , but not in LMG and OG.
Exercise training consisted of @number@ session / week of resistance training on pulley machines.
Exercise training has become part of the standard care for patients with cardiovascular disease.
Exercise training improved CRF and muscle strength in all age groups ( P < 0.05 ) , and no significant differences were observed between groups.
Exercise training , in addition to improving muscle function , reduces these circulating pro-inflammatory cytokines.
Exercise training increased hippocampal volume by @percent@ , effectively reversing age-related loss in volume by @number@ to @number@ y.
Exercise training programs primarily consisted in lower limb endurance training interventions ( mean duration = @number@ weeks ) .
Exercise volumes were multiplied by metabolic equivalent of task ( MET ) scores to calculate MET-minutes per week.
Exercise was associated with a lower risk of cognitive impairment at 10-year follow-up but was not significant at 5-year follow-up.
Exercising at levels below the set point will result in ageing being contaminated by the unpredictable and pathological effects of inactivity.
Exercising in mid- and late life had an additive synergistic interaction in reducing the risk of MCI.
Exercising , shopping , socializing , and social activities were especially likely to take place outside of residential tracts.
Exercising the mechanisms responsible for dynamic stability control in old adults affects their ability to regain balance after forward falls.
Exergames appear to be an effective way to train postural control in older adults.
Exergaming has shown to be a potentially effective and more enjoyable form of exercise delivery.
Exergaming may be an effective strategy to increase physical activity participation among rural older adults.
Exertional dyspnea was defined as moderate to severe ( modified Borg index ) immediately after a 400-meter walk test ( 400MWT ) .
Exertional leg symptoms were established by the San Diego Claudication Questionnaire.
Ex Fr. )
Exhaled nitric oxide ( F PURPOSE : Pattern onset VEPs do not always show distinct C1-C2-C3 peaks and troughs.
Exhaustion and slowness were the only individual frailty criteria significantly associated with UTP tertiles.
Existence of cognitive impairment ( Short Portable Mental Status of Pfeiffer ) and comorbidity ( abbreviated Charlson index ) were considered to be confounding variables.
Existent literature has reinforced that physical activity participation influences development of positive affect for the elderly.
Existing country-specific heart failure costs analyses were expressed as a proportion of gross domestic product and total healthcare spend.
Existing cross-sectional research demonstrates an association between reminiscence functions and well-being in later life.
Existing data about perioral aging has not yet been transformed into a consistent therapeutic concept.
Existing data on the association between being overweight and cardiovascular morbidity and mortality risk in adults are inconsistent.
Existing ethical frameworks may provide a helpful starting point for education about dementia care.
Existing evidence on these nutritional compounds , as they relate to the sirtuin system , is reviewed.
Existing evidence suggests that both ablative laser resurfacing and fractional laser treatments are effective in reducing AKs and photodamage.
Existing examples suggest that lncRNAs have fulfilled a wide variety of regulatory roles at almost every stage of gene expression.
Existing explanatory models describe some but not all of these , and modelling of entire curves has hitherto necessitated an assumption of multiple distributions.
Existing fluctuations in demand for ICU care offer an opportunity to explore such relationships.
Existing genomic microarray data were compared between cohorts using Ingenuity Pathways Analysis.
Existing guidelines for testing developmental neurotoxicity ( DNT ) propose investigations in rodents , which are ethically questionable as well as time and cost intensive.
Existing literature has reported on the suboptimal treatment of pain in this orthogeriatric cohort.
Existing literature indicates that elderly Korean immigrants may experience higher levels of depression than other racial ethnic group elders.
Existing literature on the experiences of men with LUTS is scarce given that only a few studies explored medical care-seeking behaviors and coping strategies.
Existing liver volume models based on body surface area ( BSA ) and body weight and height were implemented for comparison.
Existing methods for measuring such diversity are qualitative , expensive , and / or of uncertain accuracy.
Existing neurocognitive theories of aging have argued that such changes are either beneficial or detrimental.
Existing parametric models for estimating dynamic variance components suffer from various drawbacks such as limitation of predefined functions.
Existing preoperative risk assessment strategies are not adequate to meet the needs of the aging population.
Existing public health systems were perceived as overburdened and insensitive towards the elderly.
Existing reports on the frequencies of neurodegenerative diseases are typically based on clinical diagnoses.
Existing research on the health care utilization patterns of older Canadians suggests that income does not usually restrict an individual's access to care.
Existing reviews focused on web-based interventions for caregivers have been limited to single illness populations and have mostly focused on the efficacy of the interventions.
Existing reviews were also considered.
Existing strategies create this partition based on the predicted response probabilities , or propensity scores , from the fitted model.
Existing studies of patient tolerability , however , are limited.
Existing therapies for SDB such as continuous positive airway pressure could delay the onset to mild cognitive impairment or dementia in normal elderly individuals.
Existing treatments for OA provide pain relief and some anti-inflammatory effects , but no truly disease-modifying treatments are available for this disease.
Exogenous administration of D-serine in rodents has demonstrated pro-cognitive effects in several brain functions , including memory and executive function.
Exogenous application of CGRP inhibited Ang II-induced EPCs senescence by down-regulating the expression of NADPH oxidase and reactive oxygen species production.
Exogenous crystals , in combination with joint motion , result in substantial joint inflammation.
Exogenous NADH and NAD ( + ) may aggravate and attenuate the aging phenotypes induced by NaDC3 , respectively.
Exogenous short-term glucocorticoid administration may elicit a hypomanic syndrome with mood , sleep and cognitive disruptions.
Exogenous sources of AGEs are diet and smoking.
Exogenous synthetic inhibitors , which may augment their inhibitory potential , are considered as possible therapeutic tools for the treatment of neurological disorders.
Exogenous T administration is now used widely to elevate serum T levels in hypogonadal men and thus to treat symptoms of hypogonadism.
Exome sequencing revealed mutations in OPTN , SPG11 , DJ1 , PLEKHG5 , SYNE1 , TRPM7 , and SQSTM1 genes , many of them novel.
Exome-wide gene-based association tests also identified the MPHOSPH10 , TAS2R19 , and SERPINA1 genes in the discovery data set ( p < @number@.5E-6 ) .
Exonic indels in poly glycine tracts were also observed with similar frequencies.
Exon @number@ encodes the CD33 IgV domain that typically mediates sialic acid binding in SIGLEC family members.
Exon @number@ splicing tested with minigene constructs.
Exoribonuclease knockdown experiments followed by small-RNA sequencing suggested that PARN degrades miR-21 in the @number@'-to-5 ' direction.
Exoskeletons that assist walking have the potential to restore walking capacity by reducing the metabolic cost of walking.
Exosomes are extracelluar membrane vesicles that facilitate communication between glia , and have significant potential for biomarker discovery and drug delivery.
Exosomes from prostate and other cancer cells are increasingly proposed to play fundamental roles in modulating the tumor microenvironment and in metastasis.
Exosomes or microvesicles that are secreted from cells are considered to play important roles in tumor microenvironment.
Exosomes were also isolated by immunocapture and separated by size exclusion chromatography and density gradient centrifugation.
Expanding our knowledge of the history of dementia may be beneficial for its holistic understanding.
Expanding scopes of practice and clinical decision-making protocols for nurses , pharmacists , dietitians , and physiotherapists have the potential to further improve hypertension care.
Expanding upon previous research , older adults demonstrate activation across a frontal-parietal attentional control network.
Expansion of HSCs and thus HSC self-renewal ex vivo would greatly improve transplantation therapy in the clinic.
Expansion of lateral cerebral ventricles is an indirect marker of adjacent brain tissue volume.
Expansion of mesenchymal stromal / stem cells ( MSCs ) used in clinical practices may be associated with accumulation of genetic instability.
Expansion of neoplastic lesions generates the initial signal that instigates the creation of a tumor niche.
Expansion of the lateral ventricles occurs with normal aging , but dementia accelerates this process.
Expansion of these cells stands in contrast with their senescent phenotype described by several studies.
Expansion rates did not differ according to ICH location.
Expansions of treatments into earlier stages of maturation will offer opportunity to significantly improve ovarian stimulation protocols , especially in women with DOR.
Expectation and aging effects were assessed via response times ( RT ) to detect motion and electroencephalography ( EEG ) .
Expectations for application in human patients , however , suffer from a lack of sufficient clinical evidence in support of these beneficial effects.
Expectations for fitness during aging should be more robust , especially because higher fitness could bolster quality of life.
Expected growth for @number@ is @number@ percent , with an average projected growth of @number@ percent per year thereafter.
EXPECTED RESULTS : Our study aims to demonstrate that fit elderly patients can benefit from concomitant radiochemotherapy.
Expecting motion in some particular direction biases sensitivity to that direction , which speeds detection of motion.
Expeditious surgery is advised.
Expenditure is highest for renal replacement therapy ( RRT ) , especially in-hospital haemodialysis.
Expenditures were estimated with a generalized linear model ( log-link and gamma distribution ) .
Experienced barriers were concentration , work pace problems and mobility ; facilitators were support from colleagues , informal relations at work and supervisors.
Experience-dependent alterations in the human brain's white-matter microstructure occur in early adulthood , but it is unknown whether such plasticity extends throughout life.
Experience-dependent characteristics of auditory function , especially with regard to speech-evoked auditory neurophysiology , have garnered increasing attention in recent years.
Experienced general internists ( N = @number@ ) judged each interaction in the matrix in terms of likely resource utilization needed to manage the interaction.
Experienced nurses in particular should be made aware of the benefits of utilizing communication tools.
Experienced nurses used the tool significantly less than inexperienced nurses , and training had a significant positive impact on tool use.
Experience has shown that there is a lack of understanding concerning the relationship of analysis methods suitable for such data sets and their appropriate application.
Experience-related changes induced by modification of environment , physical exercise , or cognitive training affect brain structure and function.
Experiences and concerns expressed across groups were related to care recipient symptoms commonly associated with dementia , including severe memory loss and behavioral changes.
Experiences of discrimination were assessed with the 9-item everyday discrimination scale and CRP was assayed from blood samples.
Experiences of falls and fractures were also assessed.
Experiences of loneliness and social participation were collected by postintervention questionnaires from the participants.
Experiences related to aging merit investigation as etiologic influences on development of TMD.
Experience with ablation did not increase at higher levels of training ( U3-61% , U4-66% , and U5-63% ) .
Experience with my mother over the past @number@ years led me reflect on how we care for older adults.
Experiencing a low socioeconomic status ( SES ) throughout the life course has been reported to be correlated with poor health outcomes.
Experiencing higher levels of mental illness and physical dysfunction predicted high resilience scores especially for the social support resilience scale in the older adults.
Experiment 3 : pTRE-E4orf1 or -null cells were similarly treated with MCP1 or TNFα followed by doxycycline to induce E4orf1.
Experimental and clinical studies in postmenopausal conditions indicate that estrogen deprivation is associated with dryness , atrophy , fine wrinkling , and poor wound healing.
Experimental and clinical studies showed that sex and age play an important role in deciding the outcome after stroke.
Experimental and theoretical aspects will be considered , with a focus on normal ageing and cataract formation.
Experimental animal models improve our understanding of technical problems in peritoneal dialysis PD , and such studies contribute to solving crucial clinical problems.
EXPERIMENTAL APPROACH : The various biological functions of AM251 were measured in CB ( @number@ ) R-negative human cancer cells.
Experimental assays were performed in vascular smooth muscle cells ( VSMCs ) .
Experimental CMV-based vaccine vectors expressing a single MHC class I-restricted high-avidity epitope provided strong , T cell-dependent protection against viruses or tumors.
Experimental conditions included one-back tasks for auditory localization and pitch identification , and a simple sound-detection task.
Experimental data were collected while twelve young and twelve older male and female participants performed maximal effort isometric and isovelocity contractions on a dynamometer.
EXPERIMENTAL DESIGN : Forty-eight human lens nucleus samples with hardness grades III , IV were obtained during cataract surgery by extracapsular cataract extraction.
EXPERIMENTAL DESIGN : Forty-four cognitively healthy middle-age adults underwent baseline DTI and longitudinal T1-weighted magnetic resonance imaging.
Experimental design studies that examined physical activity or dietary intervention effects on weight loss or body composition changes in postmenopausal women were selected for review.
EXPERIMENTAL DESIGN : We retrospectively identified @number@ consecutive patients with incompletely resected \ "clinically relevant \ " PLGA.
Experimental evidence shows that telomere shortening induces mitochondrial damage but so far studies in humans are scarce.
Experimental evidences now indicate that memory formation relies on the capacity of neuronal networks to manage long-term changes in synaptic communication.
Experimental evidence suggests that this is partially attributable to changes in gene expression.
Experimental FRC could be a solution for facial prostheses supported by light-activated aliphatic urethane acrylate , orthodontic acrylic resin , or commercially available FRCs.
Experimental groups performed one RES involving eight exercises.
Experimentally reducing WAVE1 in N2a cells decreased the budding of APP-containing vesicles and reduced cell-surface APP , thereby reducing the production of Aβ.
Experimentally the results suggest that any investigation of visual processing in older adults must control for early changes in P1 morphology.
Experimental model organisms point to the existence of core survival and anti-ageing pathways that have been conserved throughout evolution.
Experimental models of rodent stroke have replicated this clinical epidemiology , with exacerbated injury in older compared with young female rodents.
Experimental models showed correlation between the loss of expression of desmosomal protein plakophilin-2 ( PKP2 ) and reduced INa.
Experimental pain was induced on @number@ young and healthy participants using capsaicin cream , applied on the middle volar part of the left forearm.
EXPERIMENTAL PROCEDURES : We analysed genome-wide DNA methylation and gene expression in human liver samples using Illumina 450K and HumanHT12 expression BeadChip arrays.
Experimental results covering the gestational period of 20-30 gestational weeks demonstrate segmentation accuracy achievable with minimal annotation , and precision of morphological age estimation.
Experimental results on 2-week-old to 9-month-old infant brain images show the effectiveness of the proposed method , especially compared to the state-of-the-art counterpart methods.
Experimental results show this method could facilitate the early detection of pathological brain change.
Experimental sleep restriction of younger adults has suggested that cortisol may be on the pathway between sleep restriction and cardiometabolic disease.
Experimental stroke investigators are therefore under increased pressure to resolve this problem.
Experimental studies , however , rely mostly on transgenic animal models , preferentially using mice.
Experimental studies indicate a correlation between the relative thrombus age and the strength of the thrombus-covered wall.
Experimental studies indicate that insulin signaling in the brain is related to cognitive performance.
Experimental studies of pacing in dogs have shown contractile dyssynchrony leading to diffuse alterations in extracellular matrix.
Experimental studies show NKRs on aged αβT cells may function either as independent receptors , and / or as costimulatory receptors to the TCR.
Experimental studies to evaluate the predictions of the amyloid cascade model are being continually retuned to accommodate conflicts of the predictions with empirical data.
Experimental therapies are being developed and tested with limited results.
Experimental verification of several of the predicted associations in mice confirmed our findings.
Experiment @number@ alleviated time constraints during the initial bouts of practice with full instructions.
Experiment @number@ assessed the effects of self- and other-referencing on memory for visually detailed pictures of objects in thirty-two young and thirty-two older adults.
Experiment @number@ confirmed that age-related changes in retinal illuminance did not account for delayed attentional narrowing in older adults.
Experiment @number@ demonstrated unique patterns of activation correlated with spatial , temporal , and decision-making components of causality perception.
Experiment @number@ examined natural auditory category learning , and found an age-related performance deficit.
Experiment @number@ examined whether supportive instructions would influence older adults ' use of verbal information when learning maps.
Experiment @number@ examined whether the age-related increase in distractibility can be simulated in younger adults by reducing their visual acuity.
Experiment @number@ extended these findings to irrelevant color singleton cues.
Experiment @number@ extended these findings to source memory , with young and older adults encoding verbal information in self-referent , semantic , and structural conditions.
Experiment @number@ followed the same procedure using a choice between @number@ hospitals for minor surgery.
Experiment @number@ further revealed that facial displays led to memory distortions that were age-congruent in nature.
Experiment @number@ investigated whether the age differences in distractibility disappear if visual acuity is equated across all participants in both age groups.
Experiment @number@ replicated these results in young adults using a different control induction.
Experiment @number@ revealed an age-related intra-item binding deficit for surface features under no concurrent load but not when articulatory suppression was required.
Experiment @number@ showed that , despite an age-related memory deficit , arousal manipulation produced a similar effect in both age groups.
Experiment @number@ showed that older adults can narrow their attention to one stream when given more time ( @number@ ms ) .
Experiment @number@ showed that stimulus spacing influenced the classification of auditory , but not visual , stimuli.
Experiment @number@ showed that the age-related difference in dual-task cost was not amplified by a variation in difficulty.
Experiment @number@ tested @number@ YNH on the same sound-scene pairings lowpass-filtered at @number@ kHz ( YNH-4k ) .
Experiment @number@ used a subset of retinal size and support ratio levels in children and adults.
Experiment @number@ used emotion words and Experiment @number@ used nonemotion words.
Experiment @number@ verified that conceptual integration training improved immediate recall among older readers as a consequence of engendering allocation to conceptual processing.
Experiment @number@ which included @number@ Chinese 4-year-olds ( @number@ boys ) , identified @number@ sociocognitive factors related to children's ability to tell strategic lies.
Experiments are performed on the hippocampal shapes of @number@ normal subjects across the whole life span ( 18-94years ) .
Experiments conducted inrecent years unraveled its structure and enabled the recognition of basic cellular functions.
Experiments @number@ and @number@ demonstrated that this age difference was found at various stimulus durations and sizes.
Experiments @number@ and @number@ showed that the aging condition yielded greater T2 accuracy at longer lags than did the nonaging condition.
Experiments @number@ through @number@ demonstrate that both age groups can suppress words that are emotional ( positive or negative valence ) or neutral.
Experiments on the results show a sensitivity and specificity of @number@ on the test image set.
Experiments were carried out by spiking four diverse soils with single , binary or ternary mixtures of As , Cd and Pb.
Experiments were performed in vitro using @number@ rat tracheal ASM strips supramaximally stimulated with methacholine.
Experiments were performed with Escherichia coli , strain HVH-U47.
Experiments with cutoff nits , however , showed that the product also kills larval stages inside nits.
Experiments with human medulloblastoma cell lines.
Expert commentary : There is limited evidence-based data on ART drug interactions , pharmacokinetics and pharmacodynamics in the older HIV-infected population.
Expert commentary : The underlying mechanism of UAB is not clear yet.
Expert commentary : We summarize the risks and the possible mechanisms of DM-induced brain injury and recommend strategies for neuroprotection and neurorestoration.
Expert-developed search strategies were applied in nine electronic databases.
Expertise and new devices are now opening the way to intermediate risk population.
Expertise did not interact with practice or interval.
Expertise in processing faces is a cornerstone of human social interaction.
Expertise was beneficial to pilots across the age range studied ; however , expertise did not show evidence of reducing the effect of age.
Expert NIA staff reviewed and validated projects.
EXPERT OPINION : Adipocytolysis of SMF by ATX-101 is an important step forward to the development of approved drugs for reduction of localized fat pads.
Expert opinion : Aging NHPs are not complete phenocopies of human AD.
EXPERT OPINION : An alternative approach to develop individualized therapy for each conformational disease is to modulate the global PN.
Expert opinion : Antidepressant drugs increase synaptic concentrations of biogenic amines.
EXPERT OPINION : A substantial amount of work has been conducted to address whether advancing age significantly affects drug disposition in humans.
Expert opinion : ETC-1002 is a novel oral lipid-lowering therapy.
Expert opinion : Even though diabetes is an important risk factor for osteoporosis , assessing bone health in diabetic patients is often overlooked.
Expert opinion : Humanity's lasting dream is to reverse or , at least , postpone aging.
EXPERT OPINION : In the last decade , over @number@ patents concerning dammarane derivatives for pharmaceutical have been published.
Expert opinion : In the previous IFN era , the sustained virological response ( SVR ) rate of the elderly was lower.
EXPERT OPINION : Live attenuated zoster vaccine is safe and efficacious in preventing HZ and decreasing the morbidity associated with postherpetic neuralgia.
EXPERT OPINION : Several challenges must still be overcome in the development of 3D supramolecular assemblies to efficiently fight oxidative stress.
EXPERT OPINION : Several reports have highlighted that mitochondria are a key factor in the progression of aging and neurodegenerative illnesses.
Expert opinion : The number of AMD patients is predicted to increase to ~30 million worldwide by @number@
Expert opinion : There are several outstanding goals that need to be met for the proper and safe use of immunotherapeutic drugs.
Expert opinion : tNSAIDs and coxibs may increase the chance of a heart attack or stroke.
EXPERT OPINION : Tolterodine provides a reasonable starting point when treating patients with OAB and UUI.
Experts agreed ' current standard practice ' in Scotland was best described as an average across five plausible treatment pathways.
Experts in these @number@ arenas need to be cognizant of the overlap in constructs , diagnosis , and treatment of frailty and malnutrition.
Explained variance for each of these regression models was @percent@ , @percent@ and @percent@ , respectively.
Explanation of how DNP-prepared faculty can help fill the nursing faculty shortage and strategies are explored in this article.
Explanations are directed toward traditional and nontraditional vascular factors , which may also explain or mediate the association between CKD and type of cognitive impairment.
Explanations for null findings are explored.
Explanations for the findings are discussed.
Explanations for this change are discussed.
Explanations of results for the two types of QOL measures in terms of psychotic symptomatology and adjustment variables ( PANSS and REHAB ) are discussed.
Explanations of why the association between stroke and falls was protective in areas of high social disorder are unclear , but may warrant additional research.
Explanations regarding the link between physical activity and cognitive health were provided in @percent@ of articles.
Explanatory factor analysis was used to create a shorter version of the BBS.
Explanatory multivariate models were constructed ( ) .
Explanatory variables included personal demographics , visual disability , and experiences related to participants ' hearing ability and hearing aids.
Explants were assessed by light , confocal , and scanning electron microscopy.
Explicitation interviews were conducted for the conflicting recommendations.
Explicit criteria such as the Beers criteria provide a valid instrument for describing the rate of inappropriate medication ( IM ) prescriptions among older adults.
Explicit health promotion interventions were limited and included enabling healthy lifestyles by increasing health literacy and empowerment.
Exploitation of this approach may enable the identification of molecular signatures associated with granule aging and unravel possible alterations of granule turnover in diabetic β-cells.
Exploratory analyses comparing lower- and higher-performing MCI patients showed that only higher-performing MCI patients had the characteristic scene memory pattern observed in healthy older adults.
Exploratory analyses of body mass suggested that adiposity may be a source of the inflammation linking brain morphology to cognition.
Exploratory analyses of the effects of gender on item endorsement were examined and significant differences were found for several items.
Exploratory analyses showed that these associations were generally stronger in low SES individuals.
Exploratory analysis of the impact of tamoxifen suggests that this pattern of results may be due to a combination of chemotherapy and tamoxifen.
Exploratory analysis showed that there were 0-9 strengths per patient , with unique strengths profiles for @number@ of @number@ patients.
Exploratory effect sizes ( Cohen's d , means adjusted for differences of baseline values ) were calculated to analyze group differences.
Exploratory endpoints included fine motor , visuospatial , and memory performance ; structural and diffusion MRI ; and selected blood markers.
Exploratory factor analyses conducted in both studies clearly revealed two underlying factors : emotion self-efficacy and action self-efficacy.
Exploratory factor analyses were conducted on a random half of the staff data.
Exploratory factor analysis on @number@ items identified three filial concepts : Responsibility , Respect , and Care.
Exploratory factor analysis replicated the two-factor structure reported by Ryder et al.
Exploratory factor analysis revealed six interpretable factors , which formed the basis for construction of six subscales.
Exploratory factor analysis ( SAS PROC VARCLUS ) and confirmatory factor analysis evaluated factor structure and eliminated poorly fitting items.
Exploratory factor analysis was conducted to assess two domains from cognitive leisure activities : literacy and visuospatial activities.
Exploratory factor analysis was performed to examine psychometric properties of the BSRI.
Exploratory factor analysis was used to assess construct validity.
Exploratory factor analysis was used to derive the underlying factor structure.
Exploratory qualitative analysis was conducted using ATLAS.ti to explore mechanisms behind quantitative results.
Exploratory qualitative interviews were carried out with purposive sample of @number@ nursing staff members.
Exploratory structural equation modeling ( E-SEM ) analyses examined model fit of eHEALS scores with 1- , 2- , and 3-factor structures.
Explored objects may contact multiple digits simultaneously so information about motion must be integrated across digits , a process about which little is known.
Exploring new cellular targets and new functions of Msrs is also warranted.
Exploring this interface can improve the supply and usage of health care , especially for marginalized populations.
Explosive isometric knee extension and plantar flexion maximal voluntary contractions ( MVCs ) were performed.
Explosive lower body muscle power was assessed as vertical jump height.
Explosive-type strength training led to enhanced stair-climbing performance at maximal and self-chosen speed , reflecting an improved functional ability.
Explosive-type strength training may alter kinetics and neuromuscular activity during stair ascent in elderly women.
Exponential growth in competency requirements also challenges staff's ability to provide quality patient care.
Exponential models provided a suitable fit and were used to estimate the relevant parameters.
Exponential rates are more characteristic for more severe health dimensions.
Exponential regression function ( y = b0e ( b1x ) ) can be used for the proper description of age-specific mortality change.
Exposed females had higher bile acid , globulin , and molybdenum levels , and males , higher corticosterone.
Exposing skin to @number@ nm UVA radiation oxidized roGFP localized in keratinocyte mitochondria , but not when roGFP was localized in the cytosol.
EXPOSURE Alzheimer disease risk genes.
Exposure biomarkers ( dietary intake ) , biomarkers of effects and biomarkers of disease status can be determined from these samples.
EXPOSURE : Colonoscopy within @number@ years or less.
EXPOSURE Computed tomographic scans of the chest.
Exposure measures were morning ( serum and salivary ) and evening ( salivary ) cortisol.
Exposure of human cerebral cortical slices to kynurenine also inhibited α7 nAChRs.
Exposure of human skin to solar ultraviolet ( UV ) irradiation induces matrix metalloproteinase-1 ( MMP-1 ) activity , which degrades type I collagen fibrils.
Exposure of students to didactic and clinical setting appears to be a critical element towards positive knowledge and attitude of the elderly.
Exposure periods were assessed using 4- , 24- , 48- , 72-hour moving average pre-visit.
EXPOSURES : Autopsy and 11C-PiB positron emission tomography.
Exposures : Birth year and age.
Exposures : Change in population size , population aging , disease prevalence or incidence , service utilization , or service price and intensity.
Exposures : Concentration of plasma total tau.
EXPOSURES : Depressive symptoms were measured using the Psychological subscale of the Malaise Inventory ; frequency of physical activity , by questionnaire.
EXPOSURES : Dietary sodium intake at baseline was assessed by a food frequency questionnaire.
EXPOSURES : DNA methylation levels at individual CpG sites generated from dorsolateral prefrontal cortex tissue using a bead assay.
EXPOSURE Self-reported sleep variables.
EXPOSURES : Frequency of consumption of milk and other foods during ages @number@ to @number@ years and attained height were reported at baseline.
EXPOSURES : Genome-wide SNP data and information on regular use of aspirin and / or NSAIDs and other risk factors.
Exposures included @number@ common genetic variants occurring throughout the genome.
Exposures , including medications and diagnostic testing , are contributors to acute kidney injury.
Exposures : Maternal residential PM2.5 ( particles with an aerodynamic diameter ≤2.5 μm ) exposure during pregnancy.
Exposures : N-terminal pro-brain natriuretic peptide ( NT-proBNP ) and high-sensitivity cardiac troponin T ( hs-cTnT ) concentrations were measured by electrochemiluminescence immunoassays.
EXPOSURES Serum CML and risk factors for AMD.
Exposures : The presence , number , and location of L-PVSs.
EXPOSURES : Thyroid function as expressed by serum thyrotropin levels at baseline.
Exposures to various DNA damaging agents can deregulate a wide array of critical mechanisms that maintain genome integrity.
Exposures : Usual aging process.
Exposures : Wealth quintile , based on total net worth in @number@
Exposures : Weight change from early to middle adulthood ( age of @number@ or @number@ years to age of @number@ years ) .
EXPOSURES : We used up to @number@ days of actigraphic recording to quantify the degree of sleep consolidation and ascertained APOE genotype.
EXPOSURE : The TAC of the diet was estimated using a database of foods analyzed with the oxygen radical absorbance capacity assay.
Exposure to and the clinical outcomes of these measures in robust versus frail older inpatients are not known.
Exposure to artificial gravity ( AG ) in a short-arm centrifuge has potential benefits for maintaining human performance during long-term space missions.
Exposure to a variety of exogenous toxicants also promotes ROS production directly or through indirect means to cause toxicity.
Exposure to black carbon , a tracer of traffic emissions , was estimated by a spatiotemporal land use regression model.
Exposure to childhood trauma was also associated with short LTL.
Exposure to chronic stressors is associated with accelerated biological aging as indicated by reduced leukocyte telomere length ( LTL ) .
Exposure to cigarette smoke and products of fossil fuel combustion aggravates AAT deficiency and COPD according to mechanisms that are not fully understood.
Exposure to cold , dehydration , and aging are known to contribute to the development of decompression sickness ( DCS ) in divers.
Exposure to constant light on the studied parameters was evaluated at different ages antenatal , early and late postnatal period.
Exposure to DHEAS significantly increased testosterone levels and cell proliferative response in ACSL3-overexpressing cells when compared to that in control cells.
Exposure to genotoxic agents has in general not been found to stimulate repair.
Exposure to internally deposited radionuclides is known to induce malignant tumors of various histological types.
Exposure to lifetime SLEs was ascertained by self-completion questionnaire , and beat-to-beat orthostatic BP measurement was carried out.
Exposure to more numerous potential sensitizers and for greater durations influences the rate of allergic contact dermatitis in this population.
Exposure to NSC @number@ sensitized cancer cells to the G-quadruplex-binding compound telomestatin or a poly ( ADP ribose ) polymerase ( PARP ) inhibitor.
Exposure to @number@ nm illumination bands induced a loss in cell viability with a dose dependence upon A2E concentrations.
Exposure to ovarian sex steroids during different life phases has long-term effects on women's health and wellbeing.
Exposure to oxidants results in cellular alterations that are implicated in aging and age-associated diseases.
Exposure to pesticides that inhibit ALDH may therefore increase PD risk via DOPAL buildup.
Exposure to PM2.5 contributed to more than @percent@ of the predicted harm.
Exposure to primary and aged wood combustion particles caused adverse effects to airway epithelia , apparently induced by several interacting components.
Exposure to reactive oxygen or nitrogen species is causatively linked to the disease pathologies associated with redox imbalance.
Exposure to rockets , PTLEs , global distress , and post-traumatic symptomatology were assessed.
Exposure to stress during this period can cause enduring neural and behavioral alterations.
Exposure to sun with living in an oxygen-rich atmosphere causes unwanted photodemage.
Exposure to synthetic glucocorticoids during development can result in later cardiovascular and renal disease in sheep and rats.
Exposure to tHcy , gene status and other variables of interest were obtained from assessments 4-7 years earlier.
Exposure to the nerve agent soman is difficult to treat due to the rapid dealkylation of the ( AChE ) conjugate known as aging.
Exposure to these compounds poses major risk to human health because of the potential to cause endocrine disruption.
Exposure to tobacco smoke during the first years of life appears to be a key risk factor for development of childhood overweight.
Exposure to ultraviolet radiation has been associated with extrinsic skin aging and skin cancers.
Exposure to ultraviolet ( UV ) radiation from sunlight accounts for @percent@ of the symptoms of premature skin aging and skin cancer.
Exposure to ultraviolet ( UV ) radiation induces various pathological changes , such as thickened skin and wrinkle formation.
Exposure to unfavorable stereotypes adversely affects the attitudes , cognitions , and behavior of older adults.
Exposure to UV-B irradiation ( 280-320 nm ) causes these changes by inducing matrix metalloproteinase @number@ and suppressing type I collagen synthesis.
Exposure to ZnO NPs significantly induced cytotoxicity to Caco-2 and HepG2 cells , associated with increased intracellular Zn ions but not superoxide.
EXPOSURE : Treatment with antioxidant vitamins and minerals.
EXPOSURE : Use of statin therapy for more than @number@ days.
Exposure variable data were collected from baseline study visits and medical records.
ExprEssence is available at @url@
Expressing these data as Purkinje cells / layer length allows one to adjust for the inherent curved nature of the cerebellar folia.
Expression analysis revealed an association between ABCG1 methylation and lipid levels that might be partly mediated by ABCG1 expression.
Expression and activation of CD36 is closely related to dyslipidemia secondary to diabetes.
Expression levels among genes were compared by using fragments per kilobase of exon per million fragments mapped.
Expression levels measured by the @number@ laboratories were within ±2 fold interval from the corresponding pre-encapsulation reference value.
Expression levels of cAMP and cGMP were assessed , and related signaling pathways were detected by western blot , immunohistochemistry and RT-PCR.
Expression levels of four miRNAs were studied using real-time PCR.
Expression levels of genes encoding specific transcription factors and other functionally important proteins vary upon aging of pancreatic and bronchial epithelium cell cultures.
Expression of 8-OHdG and p16 increased with the deterioration of mesangial hypercellularity and segmental glomerulosclerosis.
Expression of adiponectin receptors on B cells and adiponectin-induced PEPITEM secretion wanes with age , implying immune senescence of the pathway.
Expression of a FANCJ C-terminal fragment that interacts with BLM exerted a dominant negative effect on hydroxyurea resistance by interfering with the FANCJ-BLM interaction.
Expression of all aging biomarkers , including pro-collagen I and VII , elastin , fibrillin-1 , and SIRT1 and SIRT6 , were down-regulated by passaging.
Expression of an inactive ARG2 mutant ( H160F ) had the same effect.
Expression of Atg8a within muscle is sufficient to increase lifespan.
Expression of a truncated XRCC4 decoy or XRCC4 knock-down reduced NHEJ by more than half suggesting that repair is primarily canonical NHEJ.
Expression of Beclin1 reduced telomerase activity for about @number@ fold compared with the control while it did not affect TERT expression level.
Expression of BTLA inversely correlated with age and appears to be linked to shifting the nature of the response from IgM to IgG.
Expression of C1q , C3 , C4 , C5 and factor B mRNA increased with age in control C57BL / 6 mice.
Expression of CAXII is regulated by hypoxia and estrogen receptors.
Expression of CFTR was determined by RT-PCR , western blot , and immunofluorescence staining.
Expression of chemokine receptor @number@ ( CCR4 ) by Tregs has been shown to characterize antigen-primed activated Tregs with immediate suppressive function.
Expression of CPE-QQ in Neuro2a cells demonstrated that it was not secreted , but accumulated in the endoplasmic reticulum and was subsequently degraded by proteasomes.
Expression of CPE-QQ in rat hippocampal neurons resulted in cell death , through increased ER stress and decreased expression of pro-survival protein , BCL-2.
Expression of ER-α in microvessels of RS rats ( @number@ ± @number@ ) was unaffected by CE treatment ( @number@ ± @number@ ) .
Expression of Grx5 and Ycp4 in each of the mutants rescued the reduction rate of oxidized hPTEN.
Expression of IL-6 , TGF-β1 , OPG , and RANKL was investigated using real-time PCR and three carefully selected housekeeping genes.
Expression of LIS1 ( platelet-activating factor acetylhydrolase isoform 1b ) was assessed in CCA specimens and CCA cell lines by q-PCR and western blot.
Expression of miR-124 in A431 , a human cutaneous squamous cell carcinoma ( SCC ) cell line , decreased significantly compared to that in NHEKs.
Expression of molecules involved in IR signaling , such as IR or Akt , remained unchanged after gene transfer.
Expression of MTFP1 is coupled to pro-fission phosphorylation and mitochondrial recruitment of the fission GTPase dynamin-related protein @number@ ( DRP1 ) .
Expression of Osbpl2 in the mouse cochlea was determined by immunohistochemistry.
Expression of oxidative stress markers increased in HBE from all donors.
Expression of PDE4B protein examination showed marked degenerative changes in the epithelial lining of the seminiferous tubules.
Expression of PDE4 enzymes have been studied in testes of cryptorchid rats.
Expression of progerin alters the nuclear architecture and heterochromatin , affecting cell cycle progression and genomic stability.
Expression of selected miRNAs was further confirmed in CCA tissues and CCA cell lines by q-PCR.
Expression of senescence-associated β-galactosidase and p16 suggested induction of senescence mechanisms in glia.
Expression of several chromatin remodeler and transcriptional modifier genes strongly correlated with expression of oxidative phosphorylation and ribosomal protein synthesis genes.
Expression of SIRT1 was evaluated in @number@ cases of hepatocellular carcinoma ( HCC ) and five HCC cell lines.
Expression of SIRT1 was significantly elevated in the HCC tissues when compared to that of non-tumor tissues ( p < 0.001 ) .
Expression of the constitutively inactive RAB6 T27N mutant led to an increased solubilization of COH1 from lipid membrane preparations.
Expression of the gene encoding CS glycosyltransferase was evaluated using a real-time quantitative polymerase chain reaction ( qPCR ) assay.
Expression of the pathogenic mutants stimulated ROS production and increased mitochondrial membrane potential.
Expression of TLR7 and TLR9 in the brain was strongly regulated during different embryonic , postnatal , and adult stages.
Expression of TSLP therefore may be a useful prognostic marker , and its targeting could have therapeutic potential.
Expression of two Zn ( 2 + ) influx transporters , ZIP2 and ZIP4 , is reduced as a function of RPE age.
Expression of Vash2 mRNA was significantly increased in gastric tumor tissues compared with normal stomach tissues.
Expression profiles of miRNAs in these two groups were determined by the method of microarray assay.
Expression profiling analysis showed that high activation of the JAK-STAT and NF-κB pathways was induced by EBV infection into DLBCL cell lines.
Expression profiling showed an upregulation of genes implicated in neuronal growth , neuroprotection , and learning.
Expressions of MUC2 and MUC6 did not change significantly by H. pylori status.
Expression studies have confirmed the coregulation of p15 / CDKN2B , p16 / CDKN2A , p14 / ARF , and ANRIL.
Expression variability increased in springtime and there was an association of the probe list with immune system functioning.
Expression was correlated with a range of clinical parameters , including overall survival.
Expression was significantly stronger in somatomotor nuclei ( hypoglossal , oculomotor , facial ) than visceromotor or sensory nuclei.
Extant GSMM-based methods aim at identifying drug targets that would kill the target cell , focusing on antibiotics or cancer treatments.
Extant research on age differences in attachment orientation has yielded conflicting results and interpretations.
Extended independent living can improve quality of life for elders and their families and reduce costs associated with health and aged care.
Extended practice and appealing to prior knowledge improved explicit awareness for the stimulus contingencies for each age-group.
Extended-release metformin has contributed to adherence and improved gastrointestinal tolerability.
Extended tumor necrosis factor-A and IL-12B genotypes were also likely relevant to longevity.
Extending anesthesia consultation to functional status provides useful information for preoperative counseling and planning of postoperative care.
Extending healthy lifespan ( healthspan ) is a key translational challenge in this context.
Extending influenza vaccination of the elderly may be a cost-effective way to reduce the burden of influenza in CEE.
Extending previous findings to a social task , valence-based reversals were present in dorsal and ventral mPFC , and posterior cingulate cortex.
Extending prior work on intra-couple care , this study contrasts frail cohabitors ' patterns of care receipt from a partner to that of frail spouses.
Extending these results , we observed evidence for compensation in connectivity between vmPFC and the dorsolateral PFC during memory-dependent choice.
Extension for Community Healthcare Outcomes-Care Transitions ( ECHO-CT ) facilitates interdisciplinary communication between hospital and postacute care providers , who normally have minimal interaction.
Extension of maximal life span is currently possible in animal models with measures such as genetic manipulations and caloric restriction ( CR ) .
Extensive animal studies have shown that targeting such a fundamental mechanism can benefit highly complex diseases that share a common pathogenesis of bioenergetics failure.
Extensive association studies have been carried out in both diseases creating a large knowledge database , however , reproducible risk factors remain rare.
Extensive calcification of the vascular system is a key characteristic of aging.
Extensive culture expansion is necessary to obtain clinically relevant cell numbers , although the impact on MSCs stability and function is unclear.
Extensive exchange of lipids and their precursors occurs between the ER and mitochondria as well as between mitochondrial membranes.
Extensive laboratory data show that anthracyclines can induce the production of reactive oxygen species ( ROS ) .
Extensive literatures on help-seeking show how much social influences affect both undertreatment and inappropriate high utilization of health care.
Extensive lysosomal accumulation of lipofuscin-like autofluorescence and osmiophilic material occurred in UVA-exposed fibroblasts as detected by confocal fluorescence microscopy and transmission electron microscopy , respectively.
Extensive mitral annular calcification may undergo liquefaction.
Extensive pathophysiologic studies have provided mechanistic evidence for the dichotomous effects of estrogen on coronary artery vasculature.
Extensive predictors are entered including demographic attributes , social and economic status , health conditions , and behaviours.
Extensive pulmonary function testing was performed in all subjects.
Extensive research is being performed in order to elucidate the biology of aging , especially with the advent of newer molecular and genetic methodologies.
Extensive research on the specific needs and concerns of lesbian , gay , bisexual , and transgender ( LGBT ) older adults is lacking.
Extensive residual stress and wall thickness differences were evidenced among quadrants , with the more pre-stressed being also the thicker quadrants.
Extensive studies have revealed critical roles of activated MAPKs in the processes of cardiac injury and heart failure and many other cardiovascular diseases.
Extensive studies have shown that nuclear DNA methylation and histone modifications influence nuclear gene expression.
Extensive studies scientifically validated the beneficial effect of natural products against neurodegenerative diseases using suitable animal models.
Extensive translational medicine research is necessary to obtain a definitive mechanistic demonstration of the platelet-mediated hypothesis of colon tumourigenesis.
Extensive WMH , but not AD , was associated with higher serum concentrations of 8-isoprostane and LPH.
Extensive WMHIV was associated with higher scores on the LM-related errors factor.
Extent and amplitude of activity in the angular gyrus changed depending on semantic association strength that varied between conditions.
External experts positively evaluated the usefulness , comprehensiveness , and quality of the DONE framework.
External factors such as healthcare were least commonly endorsed across all domains.
External locus of control also had a stronger negative association with reasoning training gain for African Americans than for Whites.
External monitoring instruments included the Brief Medication Questionnaire ( BMQ ) and the visual remaining pill count.
External validation was performed in another group of patients with cognitive impairment using multinomial logistic regression analysis.
Extinction is a rare and transient phenomenon in patients with minor stroke.
Extra BP information was collected at @number@ h , @number@ days , and @number@ month after CAS.
Extracellular cysteine is involved in aging , cancer and cardiovascular disease.
Extracellular deposition of amyloid fibrils causes disease in affected animals.
Extracellular glucose and lactate concentrations , total antioxidant power , as well as reduced and oxidised intracellular glutathione levels were quantified.
Extracellular hydrogen peroxide ( H₂O₂ ) accumulated in a time- and concentration-dependent manner in HT22 cells during prolonged exposure to glutamate.
Extracellular matrix changes related to natural aging generate a stiffer extracellular environment throughout the body.
Extracellular nucleotides acting through P2 receptors facilitate natriuresis.
Extracellular single-unit recordings were conducted in the superior colliculus of anesthetized Sprague-Dawley adult ( @number@ months ) and aged ( @number@ months ) rats.
Extracellular TG2 and EGGL are therefore therapeutic targets both for specific and more generalized diseases of aging.
Extracellular thiol / disulfide redox environments are highly regulated in healthy individuals.
Extracellular vesicles are involved in numerous physiological processes , and vesicles from both non-immune and immune cells have important roles in immune regulation.
Extracellular vesicles , including exosomes , are small membrane vesicles derived from multivesicular bodies or from the plasma membrane.
Extracorporeal membrane oxygenation ( ECMO ) provides temporary support if respiratory and cardiac function is threatened.
Extracted data were divided in hand grip strength or muscle mass and stratified by elective or acute admission.
Extracted data were evaluated based on importance of determinants , strength of evidence , and methodological quality.
Extracted RNA was hybridized on Affymetrix Human Expression chips.
EXTRACTION METHODS : Data were extracted from computerized HMO files.
Extraction of articles and quality assessment of included articles were performed independently by @number@ authors.
Extraction of data was undertaken independently by two reviewers.
Extract of the mycelium of Tricholoma matsutake ( T. matsutake ) , or pine mushroom , is widely distributed in Asian countries.
Extracts and pure compounds from Fabaceae , Asperaceae and Zingiberaceae families have shown particular interest and appear most promising in the development of anti-aging products.
Extracts of CB waste have detrimental effects on the fecundity and longevity of its offspring , while being attractive to its gravid females.
Extra-mammary lesions included lymph nodes , thyroidal nodules , soft tissue lesions , ( subcutaneous and sub-scars ) , salivary glands and deep located masses.
Extraordinary survivors ( ESs ) were defined to include approximately @percent@ of the longest survivors in their sex group.
Extrapolating to system-level measures in humans , we proposed and tested the hypothesis that greater activity in OAs compensates for impaired white-matter connectivity.
Extrapolation of animal data to humans turned DHEA into a ' superhormone ' and an ' anti-aging ' panacea.
Extrapulmonary comorbidities significantly complicate the management and influence the prognosis of patients with COPD.
Extrapulmonary involvement and liver cirrhosis were also factors contributing to TB-related death.
Extra resources also will be required for intermediate , palliative care , and mental health liaison services for people with dementia.
Extraversion and Conscientiousness were related to more positive life stories , and Neuroticism was related to more negative life stories.
Extraversion decreased as people aged , with the most pronounced declines occurring in young adulthood , and then again in old age.
Extraversion , representing a blend of dominance and warmth , demonstrated an intermediate degree of relationship to both executive / verbal and emotional functions.
Extreme caution should , therefore , be used in defining \ "resistance \ " to aspirin on the basis of the results of these tests.
Extremes of low as well as high androgen levels have been associated with increased CVD risk in both men and women.
Extrinsic aging of the hands involves alterations in pigmentation , wrinkling , and texture as a result of chronic ultraviolet and environmental exposures.
Extrinsically aged skin shows signs of photodamage which include appearance of wrinkles , pigmented lesions , actinic keratoses and patchy hypopigmentations.
Extrinsic factors reflect systemic or environmental changes which alter EC and SMC homeostasis compromising vascular function.
Extrinsic factors that affect skin aging such as UV radiation can also cause malignant melanoma.
Extrinsic ( photo ) aging accelerates chronologically aging in the skin due to cumulative UV irradiation.
Extrinsic pressure by the pelvic floor muscles further raises intracavernosal pressure above maximum inflow pressure to achieve full penile rigidity.
Extrinsic stimuli such as cell culture stress can also trigger this growth arrest.
Ex vivo data from human fibroblasts identifies increased mitophagy as an early pathological change that precedes apoptosis.
Ex vivo reproduction of the conditions of the natural stem cell niche , when necessary , would provide success to tissue engineering.
Ex vivo , the prosenescent effect of circulating MPs from ACS patients was evidenced only under conditions of low shear stress.
Ex vivo work investigating neuroplasticity has been done on hippocampal slices using high frequency stimulation.
Eyebrows serve a key role in eye protection , communication , and self-expression.
Eye care planning must focus on corneal blindness as well as cataract.
Eye contact was measured using a refined eye contact scale in NDEPT.
Eye diseases were classified according to international classifications.
Eye-field transcription factors and those related to the early development of the retina have distinct expression patterns in the two layers.
Eye-gaze direction plays a fundamental role in the perception of facial features and particularly the processing of emotional facial expressions.
Eyeglass remake rate was @percent@.
Eyelid blepharoplasty is a common plastic surgical procedure in patients between the age of @number@ and @number@ and is performed by different specialists.
Eyelid care , and cosmetic dermatology in general , intends to restore balance and symmetry.
Eyelid surgery and an endoscopic forehead lift each contributed a 2-year reduction in apparent age ( p < @number@ ) .
Eye movements were recorded with the Eyeseecam system.
Eyes-closed resting electroencephalographic ( EEG ) data of @number@ patients with CHF were recorded by @number@ electrodes positioned according the international 10-20 system.
Eyes that received the @number@ μg dose were indistinguishable from controls.
Eyes with a monofocal IOL served as controls.
Eyes with existing NV that received @number@ μg VEGF Trap at P22 exhibited substantial resolution of OIR pathology at P45.
Eyes with geographic atrophy had significantly thinner choroids than age-matched controls or early AMD eyes.
Eyes with glaucoma were correlated closely with CCT using each instrument.
Eyes with posterior vitreous detachment had significantly decreased central foveal thickness ( P < @number@ ) .
Eye-tracking results revealed no significant age differences in detection or viewing time of emotional targets as a function of valence.
Eythrocytosis is the most common adverse effect of testosterone therapy in older men , while long-term risks in the prostate and cardiovascular system remain unclear.
F0 differences , decreases in the degree of spectral overlap between the markers , and shallower envelope shape all contributed to increases in gap-detection thresholds.
F0 was analyzed using the software Praat ( Version @date@ . ) .
F2-isoprostane response to IRX was significantly lower compared to IRC in young ( P < @number@ ) but not different in the older group.
F2RL3 methylation was recently identified as a biomarker closely reflecting both current and past smoking exposure.
F2 slope variations can be traced to higher level lexical differences.
F6H8 treatment led to significant reduction of corneal staining and significant increase of Schirmer I and TFBUT.
FA and diffusivity indices were correlated as function of age using Pearson correlation test.
FA and RD evidenced a less consistent pattern of change.
FABP4 and NEFA were measured on specimens collected between @number@ and @number@
Face and content validity was confirmed through the translation process.
Face and content validity were based on expert opinion.
Face cognition is considered a specific human ability , clearly differentiable from general cognitive functioning.
Face cognition thus remains a specific human ability compared with general cognition , even until old age.
Faced with ever-growing health challenges , some impoverished rural elders with poor physical health and functional limitations may lack sufficient access to basic health-care services.
Faced with funding shortage , new professional dynamics and economic models may emerge through coordinated , flexible research networks.
Faced with this possibility , it seems appropriate to give thought to the public policies that should be adopted.
Face is one of the human features which is unique and also dependent on his gen.
Facelift is the cornerstone procedure for the rejuvenation of the aging face.
Facelift , laser resurfacing , blepharoplasty , and endoscopic forehead lift all significantly contribute to a reduction in apparent age.
Face perception is characterized by configural processing , which depends on visual information in the low spatial frequency ( LSF ) ranges.
Face recognition performance worsened with age.
Faces are inherently dynamic stimuli.
Facet analyses suggest an important role for the N components of depression and hostility.
Facet degeneration was more severe at the L4 / 5 level and progressed along with IVD degeneration with age.
Facet joint width was independently influenced by age ( p < @number@ ) .
Face-to-face contact with community residents and partnerships with CBOs were most effective in enrolling caregivers into the studies.
Face-to-face interviews were conducted and data collected includes sociodemographic information , blood pressure measurements , medical history , health services utilisation , and cognitive status.
Face-to-face interviews were conducted to collect data using structured questionnaires from a sample of full-time employees ( N = @number@ ) .
Face-to-face questionnaire survey was adopted , and quota sampling was chosen to select the respondents.
Facetogenic or sacroiliac joint pain is more likely in older patients.
Face-to-to-face counseling was also more cost-effective than usual care.
Face verification , though an easy task for humans , is a long-standing open research area.
Facial aesthetics and rejuvenation techniques have been evolving , with the most commonly applied techniques being the use of hyaluronic acid fillers and botulinum neurotoxins.
Facial aging can create an appearance of volume loss and responds to volume enhancement in certain clinical scenarios.
Facial aging is a complex biological process that affects the skin and superficial musculoaponeurotic system ( SMAS ) .
Facial aging is a dynamic process involving the aging of soft tissue and bony structures.
Facial aging is a major indication for minimal invasive esthetic procedures.
Facial aging was once thought to be the result of the relentless downward pull of gravity on skin and underlying fat.
Facial augmentation using implants represents a straightforward , simple procedure with minimal risks and long-lasting benefits.
Facial defects have a significant impact on patient quality of life that has been well demonstrated.
Facial expression has been recognized as providing the most specific and sensitive nonverbal cues for pain.
Facial expressions convey emotions that form the foundation of interpersonal relationships , and many of these emotions promote and regulate our social linkages.
Facial expressions of pain and happiness were more prominent when a family member was present.
Facial fillers can be helpful in minimizing these changes by restoring youthful fullness to periocular areas that have undergone volume loss or loss of support.
Facial involvement represents a characteristic feature of a wide range of genodermatoses.
Facial perception questions were answered on a visual analog scale from @number@ to @number@ with higher scores corresponding to more positive responses.
Facial photographs were collected from @number@ Chinese women , aged 25-70 years in Shanghai , China.
Facial pigmented spots are a common skin aging feature , but genetic predisposition has yet to be thoroughly investigated.
Facial rejuvenation is a significant process involved in restoring youthfulness.
Facial rejuvenation , particularly lip augmentation , has gained widespread popularity.
Facial resurfacing procedures are becoming increasingly popular.
Facial size reduction and facial retraction are key features that distinguish modern humans from archaic Homo.
Facial skin ageing is caused by intrinsic and extrinsic mechanisms.
Facial skin characteristics were objectively evaluated at baseline and at the end of the treatment and maintenance periods using a three-dimensional imaging system.
Facial skin conditions were assessed using a Skin XP Pro system and skin microcirculation by laser Doppler flowmetry ( LDF ) .
Facial skin laxity is a bothersome sign of aging.
Facial volume loss has become widely accepted as one of the contributing factors in global facial aging.
Facial wrinkling is one of the most notable signs of skin aging.
Facilitating and maintaining excellent communication among community partners was imperative to troubleshoot implementation issues.
Facilitating multiple reuse are repositories like NeuroMorpho.Org , which ease the sharing of reconstructions.
Facilitating or inhibiting eryptosis may be a therapeutic option in those disorders.
Facilitating social activities among older adults is a promising direction for programs intended to promote mental health and successful aging among older adults in Taiwan.
Facilitation decreased as distortion increased.
Facilitation effects at short cue-target stimulus onset asynchronies ( SOAs ) were prolonged in duration for the two older groups relative to the young adults.
Facilitators included technology , a generalist role , strong sense of community , and slower pace of life.
Facilitators included the motivation to maintain physical and mental health and access to affordable , convenient , and stimulating PA options.
Facilitators to implementation included continued management support and observing the benefits to implementation.
Facilities that employed a dietitian were more likely to use a validated nutrition screening tool ( p < @number@ ) .
Facility discharge rates were adjusted using Empirical Bayes estimation.
FACILITY : Fractional lasers can be used in the dermatologist's minor procedure room for the above indications.
Facility-level factors were assessed using standardized administrator interviews.
Facing the high complication rate of actual techniques , an increasingly migrant population and the growing desire to respect the environment , alternatives are needed.
Facing the physical and psychological loud of their job , many nurses aspire to get retired before the legal age.
FACIT is a collection of HRQOL questionnaires that assess multidimensional health status in people with various chronic illnesses.
FACS analysis with JC-1 fluorescent dye established significant escalation of mitochondrial membrane potential by the extract in AMA-treated cells.
Factor analyses did not reveal a model for disease-clusters with good fit.
Factor analyses revealed four AL components corresponding to the bodily systems of interest.
Factor analysis and multivariate regression were performed for scaling food preferences and screening prognostic factors , respectively.
Factor analysis identified @number@ gait domains , of which only the pace factor predicted falls ( HR @number@ p = @number@ ) .
Factor analysis indicated that dorsal and ventral muscle groups were involved in the COP shift.
Factor analysis reduced these variables into a smaller number of components , and proportional hazards models assessed risk of major disability for the components identified.
Factor analysis resulted in a unidimensional scale consisting of @number@ items with an α of @number@ and an Eigen value of @number@
Factor analysis resulted in two-factor solution consistent with the original masculine and feminine items with high loadings and good reliability.
Factor analysis revealed that three factors ( S , QoL1 and QoL2 ) explained @percent@ of the variance.
Factor analysis showed a good model fit for two factors in the RISE : group involvement and interaction with others.
Factor analysis was adopted to examine the factor structure.
Factor analysis was applied to the whole questionnaire.
Factor analysis was performed on each questionnaire to clarify the LOH-related factors.
Factor analysis was used to aggregate the individual items into composite variables that were included as need variables.
Factor analysis was used to create @number@ factors : flexibility , fine motor skills , and balance.
Factor analysis was used to determine a four-factor structure that included dimensions of frequency-social ties , frequency-social activities , satisfaction-social ties , and satisfaction-social activities.
Factorial analysis and discriminant analysis were used.
Factorial invariance across gender was also examined.
Factorial invariance testing included systematic addition of constraints and comparisons of nested models.
Factor I correlated best with quality of life , factor II with activities of daily living , and factor III with subjective cognitive function.
Factor loadings ranged from @number@ to @number@ and item-test correlations ranged from @number@ to @number@
Factor @number@ consisted of nine items and factor @number@ of four items of the BBS.
Factors affecting caregiver burden in the Han group were the presence of private rooms for the elderly , their life satisfaction and family economic conditions.
Factors affecting exercise adherence were related to the SDT-based motivational strategies.
Factors affecting the education-disability relationship could include parental education , employment status and socio-economic characteristics.
Factors and reasons associated with Internet adoption and withdrawal were examined using both quantitative and qualitative data.
Factors associated with an increase in BMI in midlife were not associated with an increase in BMI after the age of @number@ years.
Factors associated with antibiotic use related to patients , families , physicians , and the healthcare context.
Factors associated with depression were analyzed by means of multivariate logistic regression.
Factors associated with different ART regimens were analysed using multivariable multinomial logistic regression analyses with multi-tablet three-drug regimens as the reference.
Factors associated with emergency-room visits and hospitalization were analyzed using logistic regression models.
Factors associated with excessive polypharmacy ( ≥10 different drugs ) and PIMs according to the Laroche list were studied using multilevel regression models.
Factors associated with NOAC prescribing in atrial fibrillation ( AF ) were also analysed.
Factors associated with non-adherence varied widely across studies.
Factors associated with nutritional risk were examined with restricted and full logistic models.
Factors associated with OAC prescription were analyzed in a multivariate logistic regression model with backward elimination of variables least associated with OAC use.
Factors associated with PDR include age and comorbid conditions , but not KPS.
Factors associated with self-rated health were similar between those with or without a stroke in older individuals.
Factors associated with service use among at-risk were female gender and younger age of death.
Factors associated with shorter maternal and infant TL included smoking and the use of drugs of addiction in pregnancy.
Factors associated with surgery failure were poor performance status , diffuse carcinomatosis , previous radiotherapy , and obstruction of small bowel.
Factors associated with the progression were assessed using logistic regression models while simultaneously adjusting for other significant risk factors.
Factors associated with UI were investigated using logistic regression and the impact of UI on SF-36 scores was determined using linear regression.
Factors associated with ΔCAVI ( @number@ ) and ΔCAVI ( @number@ ) were determined by multivariable regression analyses.
Factors beyond classical CV risk factors may have an important unrecognized value.
Factors contributing to meaning-in-life were associated with fewer SMCs ( p < @number@ ) .
Factors contributing to the dysregulation of age-related retinal parainflammation include genetic predisposition , environmental risk factors , and old age.
Factor scores and t values of each neuropsychological test measure were compared between FTLD and AD patients.
Factor scores derived from neuropsychological tests represented processing speed , executive function , and episodic memory.
Factor scores were retained and used as dependent variables in regression analysis.
Factors determining who develops PTSD following trauma are not well understood.
Factors identified as influencing intention to undertake these interventions may be useful in promoting or targeting these interventions.
Factors identified that may deter implementation included operating costs , impractical length , and workforce requirements.
Factors important for declining cancer treatment included concerns about the discomfort of the treatments , fear of side effects and transportation difficulties.
Factors influencing the trajectory of implementation success will be monitored on implementation wards.
Factors inherent to screening in primary care likely contributed to its low reliability and validity.
Factors in the eye that maintain low oxygen partial pressure around the lens are , therefore , important in protecting the lens from nuclear cataract.
Factors leading to primary or secondary resistance to BT injections were numerous.
Factors of risk are advanced age , cardiopathy , asthma , mastocytosis.
Factors other than education are likely responsible for the cohort effects in cognitive decline.
Factors other than protein intake explain lower muscle protein synthesis rates with advanced age.
Factors other than vascular stiffening may mediate the relationship between disordered mineral metabolism and CVD events in community-living elders.
Factors predicting renal recovery were the presence of fever , rash , and gastro-intestinal disturbance at the onset of AKI.
Factors promoting well-being at work need to be identified , which would enable targeting interventions and development in nursing work in an appropriate manner.
Factors related to BP , such as body mass index ( BMI ) , may differently affect particular aspects of 24-hour ABPM profiles.
Factors related to discussing sex included age , education , having a chronic condition , and consuming alcohol.
Factors related to laminar depth were determined with mixed-effects modeling.
Factors segregating IL-10 versus IFN-γ were predicted by active blistering or remission , and TGF-β or IL-10 versus IFN-γ by age.
Factors such as comorbidity , functional status , polypharmacy , and age-related changes in physical reserve and drug metabolism may affect therapeutic decision making.
Factors such as lifetime discrimination and internalized stigma may deter sexual minority individuals from seeking health services.
Factors such as pulmonary function , hypoxemia , hypercapnia or exacerbations contribute to the decline of cognitive functions.
Factors such as relational context , interpersonal power , and silencing can affect self-esteem and may be contributing to HIV risk in this group.
Factors such as working memory and transmission between brain hemispheres also influence joint matching task outcomes.
Factors that affect attentional control at this stage include cognitive load , task practice , perceptual training , and aging.
Factors that distinguish persons with a high concern about falling from those with low concern have not been systematically studied.
Factors that had impact on HHIE-S were analysed.
Factors that have limited the clinical translation of protection will be considered specifically in terms of signalling and structural defects.
Factors that increase the risk are foreign bodies , stones , obstruction , neurogenic bladder , kidney transplantation , immunosuppression , and pregnancy.
Factors that lead to increased dependence ( such as poor health ) also lead to an impairment in chemosensory performance.
Factors that may increase or decrease successful cognitive aging are of critical importance , particularly if they are modifiable.
Factors that may increase risk of a major disease but attenuate manifestation of physical senescence are also discussed.
Factors that might motivate at-risk drinkers to reduce drinking were asked about , and frequencies were calculated for these responses.
Factors that modified this association included preinjury intelligence , volume of brain tissue lost , and brain region injured.
Factors that modify or mediate the association between neuropathology and cognition are also discussed.
Factors that predispose to heat stroke collapse include pre-existing illness , cardiovascular disease , drug use , and poor fitness level.
Factors that were examined included cognitive reserve , neuropsychological functioning , depression as well as a lifestyle ( cognitive training ) intervention.
Factors underlying respondents ' current PHR-related activities were derived using principal component analysis ( PCA ) .
Factor VIII-positive capillaries were present but few in number , and CD3- or IgM-positive lymphocytes were absent in the synovial tissue.
Faculty mentor assessments also showed significant improvement in most competencies.
Faculty to teach and mentor doctoral nursing students are and will continue to be in short supply.
Faecal research highlighted a very scarce presence of E. coli , resulting in @number@ UFC / g of stool.
Faecal samples of @number@ healthy Japanese subjects between the ages of @number@ and @number@ years were analysed using real-time PCR with species-specific primers.
FAI , FT , BioT and estradiol levels were higher , and SHBG and adiponectin were lower in PCa than in Controls.
Failure mode analysis showed adhesive failures to be predominant.
Failure modes were predominantly cohesive after silica-coating , while application yielded more adhesive failure.
Failure of medical treatments leads to surgery in patients with persistent symptoms and radiographic signs of CRS.
Failure of response suppression to familiar information may be a sensitive marker of MTL dysfunction and memory impairment in aging and prodromal AD.
Failure of the microglia barrier and the accumulation of neurotoxic protofibrillar Aβ hotspots may constitute novel therapeutic and clinical imaging targets for AD.
Failure or malfunction of these leads to disease or social upheaval , respectively.
Failure-resistant mice showed an opposite expression pattern for both the ECM proteins and the microRNAs.
Failures of selective attention may contribute to older adults ' context memory impairments.
Failure to account for the correlation between the subgrouping variables can result in misleading ( confounded ) interpretations of subgroup effects.
Failure to achieve a result was more frequent with the direct sequencing method than with the three other methods.
Failure to appropriately respond to stress can have severe consequences for health and survival.
Failure to do better for these individuals and communities could undermine the HIV response.
Failure to maintain mitochondrial health leads to numerous maladies that include late-onset neurodegenerative diseases and cardiovascular disorders.
Failure to perform STS movements efficiently and smoothly may lead to falls.
Failure to properly control cell division mode may result in premature depletion of the stem / progenitor cell pool or abnormal growth and impaired differentiation.
Failure to recall an item from memory can be accompanied by the subjective experience that the item is known but currently unavailable for report.
Failure to recognize the potential occurrence of iatrogenic SCI might endanger patients ' lives.
Failure to respond to leptin will lead to obesity.
Failure to select and dose medications carefully in these patients may increase the risk of hypoglycemia and other adverse effects.
Failure to significantly improve cognition has frequently been attributed to failure of the amyloid hypothesis or to irreversible alteration in the brain.
Failure types of the specimens were identified after debonding.
Failure types were almost adhesive and mixed types.
Failure types were then assessed.
FA images were related to measures of successful picture naming and to word finding failures using voxel-based linear regression analyses.
Fair / poor childhood health similarly impacts midlife morbidity for both races.
FA is considered to be a measure of white matter organization / integrity.
Faith community nurses participated in an education program and completed a posttest to measure knowledge of content.
Faithful chromosome segregation in meiosis requires crossover ( CO ) recombination , which is regulated to ensure at least one CO per homolog pair.
Fall assessment usually includes a focused history and a targeted examination.
Fallers had greater stepping knee co-contraction than non-fallers.
Fallers tended to have altered consciousness prior to falling ( @percent@ versus @percent@ , OR = 2.8 ; @percent@ CI : @number@.3-5.8 ) .
Fallers with remarkable injuries had a higher incidence of hospitalization and a greater fear of falling.
Fall history did not moderate the relationship between self-efficacy and neighborhood walking.
Fall history was the strongest predictor in the three sub-cohorts.
Fall incidents in last @number@ months , the use of walking aids , fear of falling , comorbidities , and polypharmacy were recorded.
Falling is also associated with increased morbidity , mortality , nursing home admission , and medical costs.
Falling is a major health-related risk among older adults due to injuries , disability , and even death.
Falling is one of the most serious medical and social problems in aging population.
Fall is generally the main cause of fractures.
Fall prediction in geriatric patients remains challenging because the increased fall risk involves multiple , interrelated factors caused by natural aging and / or pathology.
Fall prevention deserves serious attention.
Fall prevention methods include exercise intervention , interventions other than exercise , and multifaceted interventions.
Fall prevention programs should be adjusted for difference in place of residence.
Fall rates for the two subgroups were similar at @number@ and @percent@ , respectively.
Fall rates on high doses were increased compared to medium doses ( Odds Ratio @date@ % CI : @date@ @number@ ) .
Fall rates were significantly associated with reach distance but not with reach judgment error.
Fall-related deaths among the older adult segment of the population constitute a growing public health concern that is largely preventable.
Fall-related fitness was determined from strength , balance , agility , aerobic endurance , muscle mass , and fat mass measures.
Fall-related hip injuries are a concern for the growing population of older adults.
Fall-related psychological factors included fear of falling and falls efficacy.
Fall risk was determined with the Physiological Profile Assessment.
Falls account for @number@ % of all fractures in the elderly.
Falls among community-dwelling older adults are common and dangerous , often leading to traumatic brain injury , cervical fractures , and spinal cord injury.
Falls among hospitalized older adults are a growing concern.
Falls and activities of daily living were assessed in two studies with opposite results.
Falls and associated injury and mortality are of increasing concern among aging Americans.
Falls and fall-related injuries were measured over a 12-month follow-up period using monthly postal surveys.
Falls and fear of falling were noted.
Falls and fragility fractures are common , dangerous , and important public health challenges.
Falls are a common problem among older adults that may be exacerbated by the addition of psychotropic medications.
Falls are a common problem in the elderly.
Falls are a leading cause of morbidity , healthcare use and mortality.
Falls are a major public health problem in the elderly population.
Falls are a serious health problem in the aging population.
Falls are detected when they occur and alerts are sent immediately to healthcare providers , so time to rescue may be reduced.
Falls are one of the major causes of mortality and morbidity in older adults.
Falls are one of the major health problems affecting the quality of life among older adults.
Falls are one of the most serious problems in the elderly.
Falls are strongly associated with benzodiazepines , neuroleptics , antidepressants and antihypertensives.
Falls are the leading cause of emergency department ( ED ) visits for fatal and non-fatal injuries among adults @number@ years old and older.
Falls can trigger a downward spiral in activities of daily living , independence , and overall health outcomes.
Falls during walking are a major health issue in the elderly population.
FALLS included group training , modules , teleconferences , academic detailing , and audit and feedback.
Falls in older adults are the result of several risk factors across biological and behavioral aspects of the person , along with environmental factors.
Falls in the elderly are common and often serious.
Falls in the elderly constitute a growing public health problem.
Falls lead to moderate to severe injuries , fear of falling , loss of independence and death in a third of those patients.
Falls led to a total healthcare cost of €474.4 million , which represents @percent@ of total healthcare expenses due to injuries.
Falls occurred most often while walking ( @percent@ ) .
Falls , often with serious consequences , can be the result.
Falls of the participants during the @number@ months follow-up period were recorded.
Falls on sidewalks and streets were more likely to result in an injury than were falls in recreational areas.
Falls over @number@ months were determined by tracking annual reported incidence of falls.
Falls ( @percent@ ) accounted for the most common cause of injury.
Falls prevention is important for older individuals to maintain healthy lifestyles and is an essential challenge in sustaining the socioeconomic structure of many advanced nations.
Falls represent a significant health risk in the elderly and often result in injuries that require medical attention.
Falls represent @number@ per cent of hospital accidents , and consequences range from none to serious injuries.
Falls-risk should be considered when prescribing medications that can cause orthostatic hypotension.
Falls risk was determined using the valid and reliable Physiological Profile Assessment ( PPA ) .
Falls risk was measured using the Physiological Profile Assessment , fractures were self-reported and mortality was ascertained from the death registry.
Falls were assessed retrospectively at each study visit.
Falls were assessed using monthly fall calendars , and rate of falls was estimated using negative binomial generalized estimating equation models.
Falls were associated with an increased frequency of mind-wandering.
Falls were categorized into a binary variable , comparing zero falls with one or more falls.
Falls were monitored with calendars.
Falls were recorded in a period of @number@ months before the follow-up assessment.
Falls were recorded prospectively during @number@ months through biweekly phone contacts.
Falls were recorded prospectively ( in hospital ) and retrospectively ( in the @number@ days prior to admission ) .
Falls were recorded prospectively over @number@ months.
Falls were registered prospectively ( mean follow-up @number@ months ) and one year retrospectively.
Falls were reported by participants using a validated questionnaire at two time points.
Falls were reported in @percent@ of cases , indicating PNP as a risk factor in this group of patients.
Falls were the most common complaint ( @number@ @percent@ ) .
Fall training did not sufficiently improve fear of falling , balance , or gait performance under single- or dual-task conditions in healthy older adults.
False-alarm rates indicated that participants had a response bias to No Match pairs as the SNR decreased.
False alarms were also regarded as a sign that the ambient intelligence technology is functioning.
False-positive or false-negative results were not observed among @number@ strains ( @number@ Salmonella and @number@ non-Salmonella ) used to evaluate assay specificity.
False-positives obtained with RCM in photodamaged skin are due to the presence of basal melanocyte hyperplasia and intraepidermal Langerhans cells.
Familial Alzheimer's disease provides the opportunity to investigate brain changes even before the symptoms onset.
Familial amyloidosis patients require more add-power than control individuals of similar age , and need to use reading glasses at earlier ages.
Familial and sporadic essential tremor ( ET ) cases differ in several respects.
Familial and sporadic ET had similar postmortem changes , with few exceptions , regardless of the definition criteria.
Familial CJD had overlapping MRI features with sCJD.
Familial ET was defined using both liberal criteria ( n = @number@ ) and conservative criteria ( n = @number@ ) .
Familial form shows an autosomal dominant pattern of inheritance with incomplete penetrance and variable clinical expression.
Familiarity and recollection are two independent cognitive processes involved in recognition memory.
Familiarity appears to mature relatively early in development and is maintained with aging , whereas recollection shows protracted development and deteriorates with aging.
Familiarity judgment includes knowing previously encoded data as well as completing original patterns from partial information , which are fundamental functions of recognition memory.
Familiarity may also contribute to associative recognition when stimuli are perceived as a ' unitized ' representation.
Familiarity with the treatment of these rare complications is essential for achieving the best possible outcome.
Familiar music evokes personal autobiographical memories for healthy younger and older adults as well and for those with mild to moderate AD.
Families acknowledged the health benefits but were equally concerned about social isolation.
Families and caregivers younger than @number@ and those who did not speak Portuguese were excluded.
Families are increasingly dispersed across national borders.
Families were re-interviewed every @number@ to @number@ years.
Familistic culture and public pension spending have a weak but statistically significant moderating effect on the relationship between intergenerational family ties and health.
Family attitudes towards SDM could be both.
Family-based support has been the traditional care arrangement for the elderly in China.
Family caregivers are an integral and increasingly overburdened part of the health care system.
Family caregivers experience poorer physical and mental health than their non-caregiving counterparts.
Family caregivers ( N = @number@ ) of IWD who were using ADS were interviewed daily by telephone at home.
Family caregivers ' unmet needs and the negative health outcomes they may experience demand effective , sustained clinical engagement.
Family caregivers were followed-up every @number@ months for a total of @number@ months.
Family caregiving is nonroutine help that is provided to a relative in need.
Family caregiving towards the end-of-life entails considerable emotional , social , financial and physical costs for caregivers.
Family carers ' affective responses may be related to their attributions.
Family cohesion and life satisfaction showed significant negative associations with emotional autonomy and these associations became more pronounced as participants moved from adolescence into adulthood.
Family functioning is affected by cancer diagnosis and treatment.
Family history and possession of the APOE ε4 allele were most prevalent in the amnestic group.
Family history is notable for joint hypermobility.
Family history is thus an important factor to take into account in dental health care.
Family history of CAD , aging , time to re-perfusion , and diabetes are independent predictors of MD reversibility.
Family history of prolapse was found in @percent@ of patients , whereas familial positive history of urinary incontinence was @percent@.
Family history was defined separately for affected mother or sister considering their diagnostic ages.
Family history was positive in @percent@ of all patients.
Family history was strongly associated with an increased risk of gout ( OR @number@ 95%CI @date@ @number@ ) .
Family members and staff members may see different parts of the total picture.
Family members caring for aging parents experience both negative and positive outcomes from providing care.
Family members comprised almost half of participants ' social networks , and friends comprised less than one-third.
Family members of nursing home ( NH ) residents with advanced dementia report difficulty making decisions about care toward the end of life.
Family members play an important role in both illness and old age.
Family members should be involved in the weaning process and adoption of new life habits.
Family members who reported trust described a positive end-of-life experience and less need for prescribed goals of care discussions.
Family network was directly associated with QOL and indirectly associated with it through the variable \ "years in ADHC. \ "
Family physicians are well positioned , with proper training , to effectively conduct DMCAs.
Family physicians who care for patients with HIV infection have a key role in identifying and managing many of these chronic complications.
Family ratings of treatment consistent with preferences , symptom management , and quality of care did not differ.
Family reported feeding assistance of moderate quality ; @percent@ felt the resident received less assistance than needed.
Family studies of exceptional longevity can potentially identify genetic and other factors contributing to long life and healthy aging.
Family support and health status were the most significant protective factors for depression in Chinese older adults.
Family support variables include living arrangement , family size , financial support , instrumental support , and filial piety.
Family was the primary context to how participants engaged with services , and their decisions about care were shaped by parenthood at different life stages.
Famous and unknown faces were presented in a familiarity categorization task.
FANCJ and BLM synergistically unwound a DNA duplex substrate with sugar phosphate backbone discontinuity , but not an ' undamaged ' duplex.
FANCJ-deficient cells display increased sister chromatid exchange and sensitivity to replication stress.
FarDVA declined at the faster speed ( p < @number@ ) with no effect of HTcoupling or age-group.
Far from retiring , engagement with life and society should be the norm for ageing populations.
Farmers identified with the stories and began to think and talk about the impact that aging exerts on their health and safety.
Farmers ' stories provided the foundation for the scripts.
Farm vehicles and machinery were responsible for almost two thirds of the fatal cases.
Farnesoid X receptor ( FXR ) is a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors.
Fascicular hypoechogenicity of high-resolution ultrasound is the correlate of nerve-T2-signal lesions , but contrast is inferior and difficult to quantify.
Fas-ligand was analysed since it functions in both apoptosis and inflammation.
Fast adjustments were found both during stepping and gait.
Faster-acting insulin aspart ( faster aspart ) is insulin aspart ( IAsp ) in a new formulation with faster absorption.
Faster decline in global cognition was associated with total cerebral , hippocampal and gray matter volume losses over time.
Faster head growth from @number@ to @number@ mo was associated with less internalizing problems ; otherwise we found no consistent associations with mental health outcomes.
Faster scans may reduce study costs and patient attrition by accommodating people who cannot tolerate long scan sessions.
Faster total cerebral atrophy and white matter atrophy ( frontal and parietal regions ) was associated with faster decline in verbal memory.
Fasting and postprandial C-peptide levels were statistically higher ( p < @number@ ) in the LADA subgroup vs. T1D.
Fasting blood and 24-h urine samples are processed on the day of collection and stored at @number@ °C in a fully automated storage facility.
Fasting blood glucose and lipids , circumference of hip and waist , and body mass index ( BMI ) were measured.
Fasting blood glucose and the lipid profile were determined by enzymatic methods using Envoy® @number@ reagents ( Vital Diagnostics , USA ) .
Fasting blood glutathione , plasma amino acids , and sulfate were unchanged.
Fasting blood samples for glucose , cholesterol , triglycerides , leptin , adiponectin , and total ghrelin were analyzed.
Fasting blood samples were collected to measure blood glucose , triglycerides , high- and low-density lipoprotein-cholesterols , and albumin.
Fasting blood samples were collected to measure plasma lipids , adiponectin , and HbA1c levels.
Fasting blood samples were obtained to measure HbA1c , plasma glucose , serum GA , insulin , and measures of kidney and liver function.
Fasting fullness decreased across the menopausal transition ( P < 0.05 ) .
Fasting glucose and insulin are intermediate traits for type @number@ diabetes.
Fasting glucose and lipids , and potential confounders were measured.
Fasting glucose , insulin , leptin , inflammatory profile , and blood lipid profile were also measured.
Fasting or dietary restriction ( DR ) can help prevent these via anti-ageing effects ; however , these effects in neurons are less well characterized.
Fasting PINP and OC were measured using a morning blood sample.
Fasting plasma concentrations of vitamin C were assessed by photometric detection in a cross-sectional study of @number@ women and eighty-nine men aged 62-92 years.
Fasting plasma glucose and insulin were obtained to calculate QUICKI as an index of insulin sensitivity.
Fasting plasma glucose and serum creatinine were measured at baseline and at 10-year follow-up.
Fasting plasma glucose concentration was significantly increased with ageing in the @percent@ group in the F3 generation and in the @percent@ group in both generations.
Fasting reactive hyperemia index improved with resveratrol ( @number@ ± @number@ vs @number@ ± @number@ p = @number@ ) .
Fasting serum electrolytes , creatinine , bicarbonate , glycated hemoglobin , plasma glucose and lactate levels were determined.
Fasting therapy might contribute to the prevention and treatment of chronic diseases and should be further evaluated in controlled clinical trials and observational studies.
Fasting venous blood samples were also obtained.
Fasting venous blood samples were collected in the morning , and serum DHA and EPA levels were measured.
Fasting venous blood was collected at 7 : 00 on the morning of surgery and a serum sample bank was created for analysis.
Fasting venous blood was drawn for biochemical analysis.
FAST is recruiting in the UK and Denmark.
Fast type II fibers predominated and no pure type IIB or IIB ' containing fibers were detected.
Fatal wounds were observed mainly in the head ( @percent@ ) and thorax ( @percent@ ) .
Fat augmentation was performed in all patients.
Fat content increases with age ; fat distribution may be heterogeneous when associated with cardiovascular disease.
Fat content of the pancreas ( head , body , and tail ) was examined.
Fat-free mass values , determined by bioelectrical impedance analysis , were normalized by height to obtain FFMI.
Fat free mass was calculated by subtracting fat mass from body weight.
Fat GSLs were less reliable ( ICC = @number@ @date@ ) than muscle and increased with age and body size.
Fathers are at lower risk for depressive disorder than mothers , and the graph was U-shaped.
Fatigue , ADL and QOL were assessed before and after the intervention in both groups.
Fatigue and performance , although similarly influenced by age and body mass excess , are affected by different metabolic factors.
Fatigue index was not associated with PSLL or mortality.
Fatigue is a notable clinical problem in cancer survivors , and understanding its pathophysiology is important.
Fatigue is a symptom that older persons , especially by those with chronic diseases , frequently experience.
Fatigue is the most-prevalent symptom and may interfere with recovery.
Fatigue was assessed at baseline and defined as a subjective feeling of fatigue when transferring or walking indoors.
Fatigue was measured using the Fatigue Impact and Severity Self-Assessment ( FISSA ) questionnaire.
Fatigue was measured with the Multidimensional Fatigue Inventory ( MFI-20 ) scale , Swedish version.
Fatigue was not related to treatment or disease variables including treatment type , cancer stage , time since diagnosis , and time since treatment.
Fatiguing exercises consisted of sustaining a plantarflexor isometric contraction at the target intensity until task failure.
Fat is harvested with liposuction and after centrifugation it is injected into the target areas in the face using small blunt cannulas.
Fat is redistributed from the subcutaneous to the visceral depot and increased inflammation participates in adipocyte dysfunction.
Fat mass decreased @percent@ at @number@ months and @percent@ at @number@ months.
Fat mass index was calculated as fat mass / height² ( kg / m² ) , with fat mass estimated using bioimpedance.
Fat mass may confer advantages to the developing cortical and trabecular bone compartments , provided that gains in fat mass are not excessive.
Fat mass measures significantly improved during ST + placebo , ST + TT , and TT vs. placebo.
Fat preservation lower lid blepharoplasty is the authors ' preferred technique for surgical rejuvenation of the aging lower lid.
Fat quantification is often based on computed tomography ( CT ) because fat density is distinct from other tissue densities in the abdomen.
Fat transfer for the aging face is an increasingly popular method for facial rejuvenation.
Fatty acid composition was not related to APOE genotype , age , gender or post-mortem delay.
Fatty acid concentrations in total phospholipid did not differ from control.
Fatty acid content and composition of English beef , lamb , and pork at retail.
Fatty acid-induced inflammation will increase activity of nuclear factor NF-κB , the well-known stimulator of age-related pathologies.
Fatty acids vary dramatically in their susceptibility to peroxidation and the products of lipid peroxidation are very powerful reactive molecules that damage other cellular molecules.
Fatty acids were measured using gas chromatography and incident HF was self-reported on annual questionnaires and validation in a subsample using medical records.
Fatty streak lesions and expression of IL-6 and MCP-1 in descending aortas were quantified.
Faulty Aβ clearance from the brain across the choroid plexus epithelium by megalin appears to mediate focal Aβ accumulation in AD.
Faulty inhibition is implicated in age-related working memory decline.
FA values in the PPN were significantly lower than in the surrounding white matter region and higher than in areas with predominantly gray matter.
FA values of the volunteers were obtained from PPN , inferior colliculus , cerebellar crossing fibers and medial lemniscus using histological data and atlas information.
FA values were calculated with diffusion tensor imaging ( DTI ) studio software.
Favorable mortality trends were predicted for all cancers except skin melanoma and lung cancer in women.
Favorable overall response was achieved in @number@ ( @percent@ ) patients by week @number@
FBB SUVR increased @number@.2% / year in FBB + with no change in FBB-.
FC and certain aspects of attentional dysfunction in DLB may , in part , depend upon both distributed motor and non-motor networks.
FC decrease in addition to gray matter atrophy within the Str may provide a substrate for the declining motor control in elderly.
FCP at a concentration of @number@ μg mL ( @number@ ) significantly improved the life span and tolerance against thermally induced stress in C. elegans.
FC's gender , role , individual needs , PWD behavioural problems and need for assistance played an important role.
FCs responded to the CRAWS-CV in interviews with trained research assistants.
FCT underwent a 12-wk exercise program.
FD and brain volume decrease significantly from age @number@ to @number@ years.
FD correlated significantly with revised ALS functional rating scale ( ALSFRS-R ) score a clinical measure of function.
FDCT and LDCT were significantly correlated with MPR.
FDG and PIB uptake was compared between groups on a voxel-wise basis and in regions of interest.
FDG uptake results showed hypometabolism in AD and MCI patients compared with controls.
FDH present a challenge due to the more lateral trajectory needed for their excision and thereby more muscle dissection and possibly facet resection.
FDMS training provides an alternative to traditional exercise and offers an effective strategy to increase functional ability in the elderly.
FDP decreased the number of desmosomes , whereas it increased collagen fibres in skin equivalents ( SEs ) .
FD values were estimated for brain WM skeleton , surface and general structure in both controls and ALS patients using our previously published algorithm.
Fear and shame before the examination are present and are barriers to the DRE.
Fear of both Labelling and Discrimination were associated with intentions to seek help from no-one.
Fear of falling and mobility restrictions have a significant negative impact on the quality of life of older adults.
Fear of falling and quality of life scores were assessed at baseline and 12-month periods.
Fear of falling ( FOF ) is expected to have effects on functional decline in the elderly.
Fear of falling is known to affect more than half of community-dwelling older adults over @number@ years of age.
Fear of hypoglycemia , however , did not differ significantly ( @number@.3±2.8 vs. @number@.1±3.1 ; p = 0.11 ) .
Fear of Labelling was also associated with an intention to delay proxy help-seeking.
Feasibility data collected from participants and interventionists were encouraging.
Feasibility outcomes included recruitment , compliance and safety.
Feasibility was determined by participants ' tolerance of the prescribed training dose.
Feasibility was inconsistently reported in studies.
Feasible and effective interventions are needed to reduce this burden of depression.
Feasible protective effects of PPARA gene allele G and C allele of UCP2 genes are briefly discussed.
Feature similarity between objects in the attended and unattended hemifields as well as motion speed and the number of to-be-tracked objects were parametrically manipulated.
Features of importance to old age include increased prevalence of COPD in non-smokers and rise in the rate of systemic comorbidities.
Features of self-generated thoughts were assessed using thought sampling while participants performed cognitive tasks following a stress induction or in a baseline condition.
Features of the aging kidney include macroscopic and microscopic changes and important functional adaptations , none of which is pathognomonic of aging.
Features of the TCRs indicated potentially enhanced cross-reactivity in all older donors.
Features seen on neuroimaging include recent small subcortical infarcts , lacunes , white matter hyperintensities , perivascular spaces , microbleeds , and brain atrophy.
Features significantly associated with reduced survival at @number@ and @number@ years were being older , male , and having vascular or severe dementia.
Febrile seizures affect 2-4% of all children and have a strong genetic component.
Febuxostat is the first new xanthine oxidase inhibitor since allopurinol and was licensed for use in @number@
Fecal elastase-1 concentration was measured from stool samples with an ELISA that uses two monoclonal antibodies against different epitopes of human elastase-1.
Fecal elastase-1 is a good marker of pancreatic exocrine secretion.
Fecal immunochemical tests ( FITs ) detect the majority of CRCs and some proportion of adenomas also in the proximal colon.
Fecal immunochemical tests ( FITs ) for hemoglobin are increasingly recommended and used in colorectal cancer ( CRC ) screening.
Fecal incontinence is a devastating condition that has a severe impact on quality of life.
Fecal incontinence leads to a high economic burden to the healthcare system and is an important cause of institutionalization.
Fecal incontinence should be questioned in detail and evaluated using FISI in elderly outpatients.
Fecal samples were analyzed for total lipid content.
Fecal samples were processed and analyzed using 16S rRNA gene amplicon sequencing.
Federally mandated ADs policies were followed in > 93% of all agencies.
Fed-state sarcoplasmic protein FSR was reduced similarly in ER and ER + RT compared with EB ( P < @number@ ) in both groups.
Feedback-based learning declines with age.
Feedback from practice staff and pharmacists was explored qualitatively to evaluate the acceptability of the program.
Feedback from the participants showed that the e-screening system was well accepted and more easily accessible than the original.
Feedback on the measures in relation to ease of completion and preference was obtained using a semi-structured interview.
Feedback on the usability and acceptability questionnaire was positive.
Feedback-related negativity is an event-related brain potential elicited by negative feedback.
Feedback was obtained during and after training.
Feedback was obtained from intergenerational participants who could discuss their needs and preferences for a smart nightstand.
Feeding and climbing activity , lifespan , and morphostructural changes in fly eyes also were evaluated.
Feeding-fasting patterns are an external cue that profoundly influence the robustness of daily biological rhythms.
Feeding functional foods did not alter body weight , but increased ( P < 0.001 ) serum protein concentration ( @percent@ ) .
Feeding of glucosamine to aged mice increases their life expectancy.
Feeding of larvae and adults with AR increased the fecundity while the same with RS had opposite effect.
Feeding on AR or RS supplemented food improved fecundity differently.
Feeding procedures related significantly to total scores for the four parameters , indicating its usefulness in deciding oral food intake.
Feeling constrained reveals the feelings brought on by the ageing body which are emphasised by hospitalisation but often neglected by hospital staff.
Feeling older was associated with an increased likelihood of major sleeping difficulties at follow-up in the three samples.
Feelings of guilt are associated with widespread self and social cognitions , e.g. , empathy , moral reasoning , and punishment.
Feelings of separation and yearning were the most prominent grief symptoms.
Feeling tired , sad , or worried or having insomnia at @number@ month post-HSCT was negatively correlated to HRQoL.
FEF50 and FVC significantly increased and DR decreased ( p < @number@ ) post-puberty for both sexes.
Felix Platter Hospital , University Center for Medicine of Aging , Basel , Switzerland ; There is a strong association between cognition and mobility.
Fellows ' knowledge of QI improved ( p = @number@ ) , but behavior did not change significantly across a short-term improvement project.
Female and male children mostly preferred water as a rinsing solution.
Female and older age groups were significant risk factors of visual disabilities.
Female and rural residents reported greater economic satisfaction compared to male and urban residents.
Female astronauts are more susceptible to orthostatic intolerance after space flight ; the visual impairment intracranial pressure syndrome predominates slightly in males.
Female C57BL / 6 F0 mice were fed diets containing @percent@ or @percent@ fat ( w / w ) throughout pregnancy and lactation.
Female carers of adults with an intellectual disability are increasing in our communities as those with intellectual disability live into middle and old age.
Female dentists were found more at risk of neckache , discomfort and pain in shoulder and hand than males.
Female doctors in surgical specialties had longer resting time.
Female fertility declines with age.
Female gender and older age were associated with lower likelihood of RSA-only and both-SA relative to non-SA , but with greater likelihood of SSA-only.
Female gender , diabetes and the season ( winter / spring ) were the important parameters that predicted this status.
Female gender , inverse or palmoplantar involvement and more severe psoriasis were likely associated with higher expectations.
Female gender ( p = @number@ ) was a significant predictor of subsequent lower self-rated driving ability.
Female genital cutting affects over @number@ million women worldwide.
Female had higher frequency of keratosis acitinca @number@ ( @percent@ ) and fibroma @number@ ( @percent@ ) , and that difference was statistically significant.
Female offspring were fed the same diet as their dams until the F3 generation.
Female participants having higher levels of education were more likely to identify their physician as a source of support.
Female patients had a longer survival than men over the age of @number@ ( @number@ vs. @number@ months , P < @number@ ) .
Female patients were characterized by higher age and lower PCI rate.
Female patients were more satisfied than male patients.
Female pelvic floor is a complex functional unit involved in multiple functions that extend beyond the sole support of pelvic organs.
Female prevalence increased over each time point ; male prevalence increased between @number@ and @number@ but was unchanged thereafter.
Female reproductive hormones exert important non-reproductive influences on autonomic regulation of body temperature and blood pressure.
Females aged between @number@ years and @number@ years showed longer CRRTs than males in some directions of the hand.
Females and 45-64 years old were more likely to receive antidepressants.
Females and males displayed comparable small to non-significant changes with age in pore size.
Females and males had mean MPTs of @number@ ( SE = 0.92 ) and @time@ = 0.96 ) seconds , respectively.
Females and older males tended to be more positive about dialysis experiences.
Females and those highly educated , particularly at the post graduate level , reported greater use of Web @number@ for health information.
Females and those least educated are most likely to belong to the early-onset group.
Females are found to outlive males but are more likely to live a greater part of their remaining life with disability.
Females are more likely to engage in social and performing-arts activities whereas males are more likely to engage in detachment-recovery and aesthetic activities.
Females are more susceptible than males to many autoimmune diseases.
Females are particularly at risk of age-associated pathology , spending more of their lives in a post-menopausal state.
Females are relatively protected from PD as compared with males and linkage studies suggested a PD susceptibility locus on the X chromosome.
Females consistently demonstrated the highest lifetime risk of THR at both time points.
Females diagnosed with HF showed higher rates of preserved LVEF.
Females displayed greater age-related changes in porosity and pore number than males.
Female sex , age below @number@ years , and low starting dose were risk factors.
Female sex and widowhood were significantly associated with depression.
Female sex , a younger age and a higher educational level were significantly associated with more willingness to pay.
Females exhibited higher LZC values than males , with significant differences in the anterior , central and posterior regions ( p < 0.05 ) .
Female sex , increased comorbid complexity , and increased number of medications were all significantly associated with an increased risk of an ADR.
Female sex is associated with increased paracetamol concentrations but ABCG2 genotype does not seem to affect paracetamol pharmacokinetics.
Female sexual disorders were reported by @percent@ women and dyspareunia was found in @percent@ of responders.
Female sexual dysfunction ( FSD ) affects ~50% of postmenopausal women.
Female sexual dysfunctions ( FSDs ) range from short-term aggravations to major emotional disturbances adversely affecting family and workplace.
Female sex , younger age , and higher education , wealth and physical activity were consistently associated with more favourable trajectories.
Females generally have strokes at older ages than males and , therefore , have a worse stroke outcome.
Females had higher odds of having both a mental illness and substance use disorder.
Females had higher scores on somatic symptoms , anxiety and insomnia ; they also reported higher scores on neuroticism and externality.
Females have generally more robust immune responses than males for reasons that are not well-understood.
Females have lower GMV but higher GMD than males throughout the brain.
Females have significantly higher results than males even in early childhood and throughout old age.
Females made up @percent@ of the population.
Females ( @percent@ ) were more likely to report abstinence than males ( @percent@ ) .
Females received more home healthcare services than males in all age groups.
Females tended to prefer microcosms containing CBs for egg deposition than those with water only.
Females tolerated hyponatremia better than males with mortality of @percent@ in females and @percent@ in males ( p = @number@ ) .
Female subjects had higher caudate nucleus binding compared with males with a similar near-significant difference in the right putamen.
Females used home healthcare services more frequently than males and the majority of skilled nursing services were tube replacements.
Females were at a significantly higher risk of nausea / vomiting after CD and CF.
Females were kept and fed individually and records of blood-feeding , egg-laying and survival were done daily.
Females were more likely to engage in screaming ( p < @number@ ) and oppositional behavior ( p < @number@ ) .
Females were more likely to experience balance problems than males ( @percent@ vs. @percent@ , P = @number@ ) .
Females with strong early horn growth attained primiparity at an earlier age than those with weak early growth.
Female-to-male ratio was 82 / 83 in Group I , while 32 / 25 in Group II.
Female values rose progressively with age.
Femoral artery mean blood velocity was measured by Doppler ultrasound , and LBF was calculated from femoral artery diameter and mean blood velocity.
Femoral BMD was also associated with scores indicating fear of falling , fear of fracture , and pain.
Femoral cartilage evaluations were performed using a linear array US probe ( 7-12 MHz ) .
Femoral component fracture is a rarely reported complication in cemented total knee arthroplasty.
Femoral neck ( FN ) and total hip ( TH ) BMD were highly correlated with muscle mass in both genders.
Femorotibial and patella cartilage was defined as weight-bearing cartilage ( WB-C ) and non-weight-bearing cartilage ( NWB-C ) , respectively.
Femur fracture is an emerging public health concern in aging societies , owing to the substantially high morbidity and mortality.
Femur length , midlife change in cortical bone thickness , and midlife values of CD8 T memory cells each added significant power for longevity prediction.
Fermented papaya preparation ( FPP ) ( a product of yeast fermentation of Carica papaya Linn ) is a food supplement.
Ferritin is the main intracellular protein of iron storage with a central role in the regulation of iron metabolism and detoxification.
Ferritin less than 70ng / ml is the best cutoff for identifying possible iron deficiency in RLS patients with inflammatory conditions.
Ferritin level over the range ( > 145 mcg / dl ) was detected in either cohort ( due to inflammation ) .
Ferritin levels were determined by means of chemiluminescence of blood samples obtained from subjects under control conditions.
Ferritin values > 1000 μg / l were found in @number@ patients.
Fertility is the first biological process to break down during aging , thereby making it a useful tool to understand fundamental processes of aging.
Fertilization rate was higher in oocytes with a visible spindle ( P = @number@ ) .
Ferulic acid ( FA ) belongs to the family of phenolic acids and is very abundant in fruits and vegetables.
FES-I ( p = @number@ ) and postural sway did not significantly change ( @number@ < p < @number@ ) .
Fetal calf serum is used as an antigen source in anti-CarP ELISA , and the precise target antigens have not been found.
Fetal environmental factors may influence the unborn child differently depending on timing of exposure.
Fetal growth was assessed with serial ultrasound measurements.
Fetal RPE cells were then cultured on these explants for @number@ @number@ or @number@ days.
FeTMPyP , a peroxynitrite decomposition catalyst , was used as positive control.
Fetuses and small children are more vulnerable to the neurotoxic effects of methylmercury from the consumption of contaminated fish.
FEV1 and FVC were genetically and environmentally correlated.
Fever may be the only clinical symptom at the onset of infection in neutropenic cancer patients undergoing myelosuppressive chemotherapy.
FEV ( @number@ ) % predicted was correlated with the intensity of staining for AGEs in the airways and alveoli.
Few age-related trends in consequences were seen with a slight predominance of women reporting consequences.
Few associations were observed with self-reported sedentary behavior measures.
Few attempts have been made to develop an olfactory test that captures episodic retention of olfactory information.
Few clinical studies have evaluated diagnostic performance of gFOBT through validation by colonoscopy in all participants.
Few complications were observed.
Few data are available for estimating the risks and benefits of prophylactic repair among those with such an advanced age.
Few data are available on the impact of nutraceuticals ( macronutrients , vitamins , and cofactors ) on primary inherited OXPHOS diseases.
Few data are available on the impact of short-term disuse ( < 10 days ) on muscle protein turnover in humans.
Few details about the subcellular distribution of AF organelles in AMD are available.
Few developmental studies examine both stimulus-locked as well as response-locked components.
Few differences in any environmental influences were observed.
Few differences were found between positive and negative memories , which on average had @date@ details and dated to the age of @date@ @number@ years.
Few double homozygous mutants survived weaning and died before the age of six months.
Few epidemiological studies have been conducted in this field , particularly in Europe.
Few epidemiologic investigations have evaluated the potential health effects of these foods in Asian populations.
Few epidemiologic studies have considered the impact of extreme heat events on hospitalization rates in the Pacific Northwest region.
Fewer diagnostic tests were performed in PC and diagnostic time was shorter.
Fewer individuals in Iceland were admitted to a hospital and Iceland had higher admission rate to rehabilitation compared with the overall group.
Fewer sexually active men had incontinence ( p < @number@ ) .
Fewer than half ( @percent@ ) correctly recalled the number of drugs they were taking.
Fewer US patients endorsed depression as a normal part of aging ( @percent@ vs. Korea at @percent@ and Russia at @percent@ ) .
Few findings indicate that lack of functions of E3 ubiquitin ligases can be a causative factor of neurodevelopmental disorders , neurodegeneration , cancer and ageing.
Few genome-wide association studies ( GWAS ) of complex diseases have been published from non-European populations.
Few , if any , therapies exist that target age-related laryngeal muscle dysfunction.
Few individuals consistently monitored other aspects of their cardiovascular health.
Few instruments were available to measure cultural aspects of care , structure and process of care , and continuity of care.
Few jurisdictions , however , offer a clear legislative basis for LAR identification.
Few large-scale studies measured the activity rhythm objectively in the general population.
Few large-scale surveys on dementia have been conducted in China and little was known about the magnitude of dysfunction and disability caused by dementia.
Few longitudinal studies have examined how visual impairment affects mobility as people age.
Few longitudinal studies have examined the relationship between grip strength and cognition , especially where specific cognitive abilities have been targeted.
Few methods of estimating age using the skeleton , especially cranial suture , have been tested on Thais.
Few neuroimaging studies have investigated associations between hippocampal measures and depressive symptoms in nondemented older adults.
Few of the tested associations were significant , and of those that were , most suggested a positive relationship between cortisol and cognitive ability.
Few older Aboriginal people accessed prevention programs , suggesting there is an important need for targeted Aboriginal-specific programs.
Few organs seem unaffected by the disease.
Few participants experienced cardiovascular events ( @number@ in the discontinuation group vs @number@ in the continuation group ) .
Few participants in remission exhibited marked cognitive impairment compared to age-matched peers.
Few patients had more than one dermatoses which constitute < @percent@ .Photodermatitis was found to be statistically significant.
Few predictors of uptake or adherence to online interventions have been consistently identified , particularly in individuals with cancer.
Few previous studies have used patients with non-TBI trauma ( NTT ) as controls to investigate the influence of age and TBI severity.
Few prospective studies have used fatty acid biomarkers to assess associations with type @number@ diabetes.
Few published reports examine the development of holistic face processing across the lifespan such that face-specific processes are adequately differentiated from general developmental effects.
Few rejuvenation and antiaging markers are used to evaluate food supplements.
Few reports exist describing their function and concentrations in serum.
Few reports investigate incidence rates in large family-based studies in which the participants were selected for family history of LOAD.
Few researchers have examined the effects of multiple risk factors of cardiovascular disease ( CVD ) mortality simultaneously.
Few research papers in economics have examined the extent , causes or consequences of physical stature decline in aging populations.
Few residents left these settings because of behavioral problems.
Few respondents reported attending educational sessions.
Few scattered studies show the role of collective situations , of subjects ' prior knowledge and of objects in solving the selection task.
Few sexual symptoms and diseases such as hypertension , diabetes , and obesity show testosterone dependence only at older ages.
Few specific genetic determinants of ANM have been identified.
Few specific trials have been carried out for immunotherapy in elderly people , with most patients considered to be fit.
Few students mentioned non-medical or well-being initiatives as measures to prolong parenthood.
Few studies address this group's emerging needs.
Few studies ascertained the reasons for changing driving behaviour.
Few studies assessed and explicitly reported harms.
Few studies concerning their expression , distribution and role in normal and pathological human thymus are available in the literature.
Few studies considered whether the relationship between anticipated support and health depends on the source of such support.
Few studies evaluate the effect of age on asthma.
Few studies evaluate the risk of interaction with anticancer drugs in elderly patients suffering from cancer.
Few studies examined VDR genetic variants in large-scale Asian patients with PD.
Few studies exist concerning drinking motives among treatment-seeking patients.
Few studies have addressed the possible antioxidant effects of R-SFN , which could protect cells from the free radical damage that strongly contribute to aging.
Few studies have analyzed the role of specific correlates of perceived well-being in the obese and overweight Italian older population.
Few studies have assessed the prevalence of atopy and allergic diseases in elderly persons with objective measures.
Few studies have assessed whether SCH plays a role in the increase in age-related dyslipidemia.
Few studies have compared fractional CO Cells change gene expression when they differentiate into different cell lineages.
Few studies have compared the phenomenological properties of younger and older adults ' memories for emotional events.
Few studies have detailed the associations between the G8 screening tool , ECOG-PS , and overall survival ( OS ) in such patients.
Few studies have directly compared the ability of the most commonly used models of frailty to predict mortality among community-dwelling individuals.
Few studies have directly compared the clinical and anatomical characteristics of patients with progressive aphasia to those of patients with aphasia caused by stroke.
Few studies have evaluated the effectiveness of CDSMP when offered by multiple agencies , as a collaborative effort , in community-based settings.
Few studies have evaluated whether greater losses of muscle and increases in fat are associated with more rapid decline in respiratory function in aging.
Few studies have examined cancer-related risk factors in relation to SES across the lifecourse in low to middle income countries.
Few studies have examined functional adrenal zonation throughout human life.
Few studies have examined potential ways of improving swallowing function in this fragile patient group.
Few studies have examined social engagement in long-term care facilities in non-Western countries.
Few studies have examined the association between LS in the oldest-old and not only health-related , but also psychological and socio-economical factors.
Few studies have examined the association between specific symptom dimensions of depression and brain volumes.
Few studies have examined the health-related consequences of gardening among older adults.
Few studies have examined the predictive ability of physical performance measures exclusively within populations of the very old.
Few studies have examined the relationship between CSF and structural biomarkers , and cognitive function in MCI.
Few studies have examined the relationship between self-efficacy for dementia-related tasks and symptoms of burden and depression in caregivers.
Few studies have examined working memory ( WM ) training-related gains and their transfer and maintenance effects in older adults.
Few studies have explored nonlinear relationships or considered interactions with other biomarker measures.
Few studies have explored older people's expected future quality of life ( QoL ) , despite evidence that perceptions of one's future influence healthy aging.
Few studies have focused on modifications over time of the cognitive function in the healthy elderly.
Few studies have focused on perceptions of healthcare among Vietnamese who came to the United States ( US ) as refugees.
Few studies have focused on the cognitive functioning in older adults.
Few studies have focused on the effects of aging on allografts in the state of tolerance.
Few studies have focused on the presence of healthcare discrimination and its effects on older adults.
Few studies have focused on the trends of pre-hypertension and hypertension specifically for the aging population in China.
Few studies have investigated back muscle fatigue in older people.
Few studies have investigated bone microarchitecture and biomechanical properties in men.
Few studies have investigated the association between lifetime SES and mortality among elderly adults.
Few studies have investigated the association with CRC by molecular tumor features , which could provide relevant information on associated molecular pathways.
Few studies have investigated their association with subclinical coronary heart disease.
Few studies have investigated what factors influence different levels of prescribing of these agents.
Few studies have investigated whether age modifies the association of physical work demands with health.
Few studies have presented a detailed example of a humanistic endeavor organized by medical students to facilitate student interactions with healthy older adults.
Few studies have provided detailed evaluations of the diet of childhood cancer survivors.
Few studies have related dietary patterns with cognitive impairment in Chinese population.
Few studies have reported BDNF serum levels in elderly depressed subjects and their relationship with antidepressant therapy.
Few studies have systematically documented whether or how selectivity into retirement shapes the relationship between retirement and cognitive aging.
Few studies have used acceptable designs for testing treatment effects , sample sizes or primary outcomes that could provide interpretable findings or effects across studies.
Few studies , however , have assessed multiple components of memory in a single sample.
Few studies , however , have compared the AFI with the BMI as a measure of obesity.
Few studies , however , have described the trends for SCC , as population-based data with a long follow-up are limited.
Few studies , however , have examined long-term , longitudinal , anatomical brain changes comparing healthy ɛ4 + and ɛ4- individuals.
Few studies , however , have focused on what helps residents to find a home in long-term care settings.
Few studies , however , have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan.
Few studies , however , have investigated the associations of air pollution on hemoglobin levels and anemia.
Few studies investigated reliability ( n = @number@ ) and sensitivity to change ( n = @number@ ) .
Few studies investigated these changes with age.
Few studies of cognitive ability have tested the same individuals in youth and old age.
Few studies reported age-specific outcomes.
Few such tools exist in German.
Few tests were non-susceptible to practice or limited by ceiling effects.
Few to moderate densities of neuritic plaques but widespread phospho-TDP-43 pathology was observed in five patients.
Few village characteristics were associated with PA ; however , villages located in more walkable neighbourhoods increased participants ' odds of transport walking.
Few women received counseling about sexual concerns or the safety of returning to sex.
FFA and glycerol increased with reduced activity ( p < @number@ ) , but reverted with training.
FFA concentration was measured in duplicate by the Wako enzymatic method.
FFAs were correlated with established serum markers of cardiovascular risk and strongly related to secondary cardiovascular events and all-cause mortality in age- and gender-adjusted analysis.
FFM remained stable up to @number@ years of age and was lower first among the @number@ years of age.
FFM was derived from Dual-energy X-ray absorptiometry analyses.
FFQ significantly underestimates dietary intake and should not be used to assess the absolute intake of foods and nutrients in childhood cancer survivors.
FFRs were elicited by tonal sweeps in six conditions.
FFT amplitude of the consonant-vowel FFR fundamental frequency did not significantly decline with increasing age.
FGD5 promotes apoptosis-induced vaso-obliteration via induction of the hey1-p53 pathway by direct binding and activation of cdc42.
FGF21 also controls stress responses and metabolism by modulating the functions of somatotropic axis and ( HPA ) pathway.
FGF21 is a potent longevity factor coordinating interactions between energy metabolism and stress responses.
FGF-23 is a bone-derived hormone that suppresses phosphate reabsorption and @number@ dihydroxyvitamin D ( @number@ ) ( vitamin D ) synthesis in the kidney.
FGF23 is a circulating factor produced by osteocytes that inhibits renal phosphate reabsorption and 1-alpha-hydroxylase activity.
FGF23 is an early biomarker of renal injury and increased FGF23 predicts adverse clinical outcomes , in particular cardiovascular disease.
FGF23 may have both direct and indirect effects on the cardiovascular system.
FG that has spread to the male genital organs presents therapeutic challenges.
FHyC was often associated with E atrophy.
FI assessment was based on the Fecal Incontinence Severity Index ( FISI ) .
Fibrate therapy had no effect on TBV compared with placebo.
Fibre intake was assessed by means of a validated 136-items semiquantitative food-frequency questionnaire.
Fibrillar protein aggregates are the major pathological hallmark of several incurable , age-related , neurodegenerative disorders.
Fibril morphology was analyzed by transmission electron microscope ( TEM ) .
Fibrinogen adsorption initiates platelet activation , and causes a rapid increase in pressure across microchannel networks , rendering them useless for long term applications.
Fibrinogen , LDL-cholesterol , oxidized-LDL and sVCAM correlated negatively to endothelial function but not to microcirculatory parameters.
Fibrinogen , LDL-cholesterol , oxLDL correlated negatively to %Hyper while sVCAM correlated negatively to %Hyper and RBCVmax / RBCVbaseline.
Fibroblast growth factor ( FGF ) @number@ and Klotho are two factors associated with several metabolic disorders.
Fibroblast growth factor @number@ ( FGF21 ) is an endocrine factor that regulates glucose and lipid metabolism.
Fibroblast growth factor @number@ ( FGF21 ) is increasingly recognized as an important metabolic regulator of glucose homeostasis.
Fibroblast period length was measured via cyclical expression of a lentivirally delivered circadian reporter.
Fibroblast primary cultures were carried out , seeding cells on a layer of Gluc or PDRN alone or in combination for @number@ h.
Fibroblasts activated by bryostatin-1 protected the structural integrity of HSEs.
Fibroblasts and adipose-derived stromal vascular fraction cells can be clinically used as injectable tissue-engineered soft tissue at present.
Fibroblasts and non-follicular skin derived precursors were identified as main source for periostin expression in human skin.
Fibroblasts are cells of mesenchymal origin.
Fibroblasts from newborns and older patients differed namely in terms of nestin expression and also in the production of extracellular matrix components.
Fibroblasts participate in the wound repair process through proliferation and migration as well as the synthesis of factors growth and extracellular matrix molecules.
Fibroblasts were also exposed to a subtoxic dose of UVA combined with a red light-emitting diode ( LED ) for five continuous days.
Fibroblasts were incorporated in collagen lattice disks.
Fibroblasts were treated with WJ-MSC-conditioned medium ( WJ-MSC-CM ) or nonconditioned medium.
Fibromyalgia is associated with physical disabilities in daily activities.
Fibromyalgia syndrome ( FS ) frequently co-occurs with regional pain disorders.
Fibronectin was also increased by @percent@ after treatment.
Fibrotic disorders account for an increasing burden of disease-associated morbidity and mortality worldwide.
Fibrotic kidneys induced by unilateral ureteral occlusion ( UUO ) displayed marked Klotho suppression and the promoter hypermethylation.
Fidelity , dose , adherence , safety , cost , and health care utilization will also be examined in the implementation component of this study.
Fidelity of coaching practices with respect to workshop curriculum was confirmed.
Fidelity of this process is the basis of mitochondrial homeostasis , which is disrupted in pathological conditions and aging.
Field-based measurements of age , height , weight , body mass index ( BMI ) , and handgrip strength were recorded on an individual basis.
Field hockey players displayed a larger range of flexion , side bending and rotation to the right.
Fields receiving high dose radiation are evaluated in terms of adverse effects , therapeutic efficacy and secondary malignancies in radiotherapy applications.
Field studies on age-shift work interaction effects on sleep , fatigue , performance , accidents and health were reviewed.
Fieldworkers blinded to assignment assessed socio-demographic , dietary and anthropometric data during follow-up at ages @number@ @number@ and @number@ years.
Fifteen articles met our review criteria.
Fifteen articles were eligible for inclusion.
Fifteen CIDP patients ( @percent@ ) were IgG4 anti-human NF155 antibody-positive , which were confirmed by western blot , cell-based assay and immunohistochemical study.
Fifteen cross-sectional and seven longitudinal studies examining arterial stiffness and cognition were identified.
Fifteen discontinued treatment ( @number@ assigned to placebo ) ; all were followed for the entire study period.
Fifteen drugs studied to date exerted no clinically significant effects in vivo.
Fifteen female volunteers were enrolled ; they applied creams once daily for @number@ days.
Fifteen healthy volunteers participated per group.
Fifteen individuals ( @number@ men , @number@ women ; mean age ± SD , @time@ ± @number@ years ) participated.
Fifteen items were identified as being potentially useful , and the preferred instrument design was identified.
Fifteen male , age-matched former professional non-contact sport athletes ( mean age @number@ [ SD @number@ ] years ) served as controls.
Fifteen men ( @number@ endurance-trained , @number@ weight-trained , and @number@ sedentary ) provided muscle samples from their vastus lateralis muscle.
Fifteen-month old female Hairless mice underwent @number@ h of paradoxical sleep deprivation or @number@ days of chronic sleep restriction.
Fifteen of eighteen MNA items show a significant correlation to the total MNA score ( p < @number@ ) .
Fifteen of these Rhox5-regulated genes were chosen for further analysis.
Fifteen pairs of adjective ratings were extracted through factor analysis.
Fifteen participants had biomarkers indicating increased risk of AD , two of which were CDR = @number@
Fifteen patients completed the study and were analyzed.
Fifteen patients had documented optic atrophy.
Fifteen patients ( @percent@ ) met diagnostic criteria for ES , @number@ ( @percent@ ) of whom received systemic steroids.
Fifteen patients received PRF of the articular branches of the femoral and obturator nerves , and @number@ patients received conservative treatment.
Fifteen patients were not administered unfractionated heparin in the perioperative period ( no-heparin group ) .
Fifteen patients with dilated facial pores underwent three laser treatments at 3-week intervals.
Fifteen percent of all participants had a non-exponential MPOD spatial profile.
Fifteen per cent of clinics stated that their therapies posed no risk.
Fifteen research teams participated with a total of @number@ algorithms.
Fifteen residents from nursing homes were recruited among the participants in a larger quantitative study who reported having pain.
Fifteen residents were recruited to participate in the longitudinal prospective cohort feasibility study , four of whom died during the data collection period.
Fifteen self-reported disease symptoms were included as outcome variables.
Fifteen SNPs were chosen in order to cover the known common variation in FOXO3A.
Fifteen studies analyzed the association between malnutrition and frailty , which was significant in @number@ of these.
Fifteen studies out of @number@ investigated what was rather associated with an unfavourable self-rated health.
Fifteen subjects were studied for @number@ consecutive weekdays before , and one month after , their cataract surgery.
Fifteen treated with double PPH-01 staplers and @number@ treated using new CCS @number@ contour.
Fifteen trials of three steps were performed for both stair ascent and descent.
Fifteen unmedicated MDD inpatients and @number@ age- and sex-matched healthy controls participated in this study.
Fifteen unsupplemented , age / gender-matched healthy subjects served as controls.
Fifteen volunteers SBRN cross sectional area was measured by ultrasonography ( US ) .
Fifteen young adults and @number@ older adults participated in this study.
Fifteen young and @number@ old adults responded only to the last event in a series of discrete 3-event sequences or triplets.
Fifth , abundance of target sequences present in the genome will likely dictate the effectiveness and efficiency of targeted insertions.
Fifth , how do functional interactions change with aging ?
Fifthly , repeat the iteration until all the deviation candidates are involved and get the optimal deviation with maximum fitness values.
Fifty-eight Chinese , Malay , and Indian Singaporean women participated in interviews that were audiorecorded , transcribed verbatim , and analyzed using thematic analysis.
Fifty-eight participants ( @number@ females ) judged whether pairs of photographs were of the same or different identity.
Fifty-eight percent of the variance in the observers ' perceived distance ratios could thus be accounted for by variations in the actual stimulus ratios.
Fifty-eight percent were women ( n = @number@ @number@ ) , and @percent@ were non-Hispanic white ( n = @number@ @number@ ) .
Fifty-five men ( @percent@ ) were identified as having LOH ( @number@ moderate and @number@ severe ) .
Fifty-five participants demonstrated new-onset of mild parkinsonian signs.
Fifty-five participants of increasing age ( 20-30 , 40-50 , 60-70 , 75-85years old ) were recruited.
Fifty-five patients were enrolled ( @number@ RLA and @number@ TLA ) .
Fifty-five patients were excluded predominantly because of insufficient clinical information.
Fifty-five percent of the total group declined in ADL , @number@ % in IADL , and @number@ % in mobility.
Fifty-five subjects with DSM-IV MDD were included in the study.
Fifty-five VTEs occurred during follow-up.
Fifty-four APNs completed a questionnaire developed by the author based on the aging literature , advanced practice nursing competencies , and UI guidelines.
Fifty-four male professional soccer players from @number@ different teams of @number@ European countries ( Italy and Germany ) participated in the study.
Fifty-four mRNAs and @number@ miRNAs were DE by gender.
Fifty-four patients ( @percent@ ) had experienced falls in the past year.
Fifty-four percent respondents stated that his / her pharmacy helped patients obtain financial assistance while patients were in the Donut hole.
Fifty healthy volunteers were enrolled in this study , consisting of @number@ males and @number@ females with median age of @number@ years.
Fifty inpatients , @number@ women and @number@ men ( mean age @number@ years ) were included.
Fifty liver biopsies of HCV-infected patients were examined.
Fifty-nine healthy adults , @number@ young and @number@ older adults , were randomly assigned to either training or no-contact control groups.
Fifty-nine patients ( @number@ females ) were octogenarians.
Fifty-nine percent ( n = @number@ ) preserved their AEE and @percent@ ( n = @number@ ) declined.
Fifty-nine percent of patients who went on to rhytidectomy did not report regret over this cost expenditure.
Fifty-nine subjects , consisting of a young , middle and old group , were studied using functional MRI and a motor activation paradigm.
Fifty-one HBeAg negative patients were enrolled.
Fifty-one older adults from the surrounding community participated in the study's groups.
Fifty-one older adults wore an accelerometer on the hip for @number@ days and completed the CPM and TS tests.
Fifty-one participants witnessed an unexpected live event , and @number@ hours later were interviewed using one of three aforementioned techniques.
Fifty-one patients received medication for agitated behaviour.
Fifty-one percent of all of the treated participants reported treatment-related adverse reactions.
Fifty-one ( @percent@ ) subjects died during the @number@ months of follow-up.
Fifty-one subjects completed the study , doenjang ( n = 26 ) and placebo ( n = 25 ) groups.
Fifty patients were included in a one-year follow-up study , assessing fall events and scoring average physical activity at home in telephone interviews.
Fifty patients with focal epilepsy aged @number@ years and older and @number@ patients aged between @number@ and @number@ years were included.
Fifty percent of non-white survivors were deceased @number@ years post diagnosis , compared to @number@ years in white survivors.
Fifty sedentary healthy men ( @number@ ± @number@ years , @number@ ± @number@ m , @number@ ± @number@ kg ) volunteered for the present study.
Fifty sedentary males were randomly divided into five groups.
Fifty sessions were held in @number@ cities across all @number@ regions of the province.
Fifty-seven men and @number@ women aged @number@ to @number@ yr were randomly assigned to @number@ mg DHEA or placebo once daily.
Fifty-seven of the healthy subjects also completed a food-frequency dietary questionnaire.
Fifty-seven out of @number@ ( @percent@ ) women were infected postpartum as assessed by qPCR , whereas prevalence by optical microscopy was only @percent@.
Fifty-seven percent of families and caregivers classified delirium as an extremely distressing experience.
Fifty-six community-dwelling older adults aged 60-80 years old were randomly assigned to an intervention or control group.
Fifty-six huddles occurred over a 12-week period ; two to seven direct-care staff participated in each huddle.
Fifty-six participants [ age : 70 ( @number@ ) years ; @percent@ female ] were included in this study.
Fifty-six patients ( demented and nondemented ) had late-onset seizures.
Fifty-six percent of participants reported difficulty with grocery shopping.
Fifty-six proximal tibias from @number@ Japanese men and women ( 57-98 years of age ) were used in this study.
Fifty-six specimens were selected for this study and distributed into the following four age groups ( n.
Fifty-three per cent of clinics requested access to patients ' medical records , and @percent@ recommended patients discuss the proposed therapy with their doctor.
Fifty-three percent underwent omentectomy.
Fifty-three studies were included totalling @number@ seniors aged @number@ years and over.
Fifty to sixty percent of hearing loss is thought to have a genetic cause.
Fifty-two centenarians ( @number@ % ) survived ≥360 days.
Fifty-two healthy children ( @number@ boys and @number@ girls ) , aged 6-14 years , were enrolled in this cross-sectional investigation study.
Fifty-two healthy older participants underwent PIB-PET and structural MRI scanning and detailed neuropsychological tests.
Fifty-two of them demonstrated degenerative endplate marrow changes.
Fifty-two patients died in the period from hospital admission to three months after discharge ( survival rate @percent@ ) .
Fifty-two patients entered in the EADB-100 group and @number@ in the EADB-200 group.
Fifty-two percent of the respondents indicated that their courses included some form of on-line learning component.
Fifty-two percent were women , and @percent@ were white.
Fifty-two publications from @date@ , to @date@ , were identified for inclusion.
Fifty-two subjects had a current major depressive disorder , and @number@ age- and sex-matched controls had no history of depression or any mental illness.
Filaments showed ∼2-fold enlargement in width and displayed numerous protrusions and splayed ends consistent with unfolding of tau and diminished structural stability.
Filipino caregivers more often emphasized positive aspects of caregiving , whereas Whites often expressed that others do not understand the daily experiences of caregiving.
Filipinos also exhibited the greatest number of chronic diseases , including the highest rates of asthma , high blood pressure , and heart disease.
Filipinos more commonly described caregivers as a ' good person ' or ' saint ' and emphasized that caregiving made them stronger.
Filler characteristics such as longevity and reaction within the tissue and complications such as migration and granulomas could be visualized.
Fillers are known to be associated with a number of side effects , one of the most severe being skin necrosis.
Fillers , botulinic toxin injections , transpalpebral , endoscopic or bicoronal brow lift must be usual techniques for every plastic surgeon in overall facial rejuvenation.
Filling was assessed from time-resolved LV volume curves.
Film , dance , and music were the most popular arts for this sample prior to hospital stay.
Filter substances like those used in sunscreens for skin protection in the ultraviolet region are not available for the visible and infrared spectral regions.
FIM has been shown to predict discharge outcomes and those at high risk for falls.
Final detention outcomes were significantly different between the consultant and non-consultant groups.
Final diagnosis was clear cell endometrial adenocarcinoma arising from endometriosis foci within the caesarean section scar.
Final functional independence measure ( FIM ) scores and length of in-hospital stay were the outcome measures.
Finally , 12-15LO-dependent alteration of tau metabolism was independent from an effect on Aβ.
Finally , a basic approach to implanted devices ( which often accompany pacemaker devices ) is presented.
Finally , a brief overview of clinical applications of MSCs in bone regeneration and repair is presented.
Finally , a compartmental model suggests intracellular , rather than extracellular , assembly of Lp ( a ) .
Finally , activation in the ventromedial prefrontal cortex during outcome was not affected by age.
Finally , administration with baicalein significantly decreased the incidence of tumor formation with inflammation.
Finally , a factor analytic strategy was used to identify HC-QIs that cluster together and thus are candidates for summary scales.
Finally , aged MSCs are unable to rescue age-associated impairments in cutaneous wound healing.
Finally , age-related brain complexity changes must be considered when investigating pathological brain because typical brain complexity is not constant across generations.
Finally , age-related changes of endocrine signals have been proposed to exacerbate the loss of brown adipose tissue.
Finally , age-related differences in strategy performance were found.
Finally , a high number of probes showed significant season-specific expression variability within subjects.
Finally , ALA significantly ameliorated vitamin D ( @number@ ) -induced aortic calcification and mitochondrial damage in mice.
Finally , all healthcare providers should be made aware of frequently occurring precipitating factors for hypoglycaemia , so that they can take timely precautionary action.
Finally , although each unit of RBCs is probably unique , a metabolic signature of RSL across storage variables might exist.
Finally , AM251 displaced diethylstilbestrol prebound to the ligand-binding domain of ERRα.
Finally , a measure of executive function predicted the impact of accent on SRT.
Finally , a model for integrating individual geriatric interventions into a broader system is proposed.
Finally , anabolic stimuli such as feeding and exercise may help highlight any discrepancies in protein turnover between men and women.
Finally , analysis of the rating scale structure confirmed the functioning of the 0- to 5-point rating scale used.
Finally , and most importantly , do the technologies and methodologies exist to facilitate an unbiased search for gene-environment interactions ?
Finally , androgen therapy improves endothelial dysfunction.
Finally , an innovative approach on investigating human aging process is suggested , which involves the base composition of genes.
Finally , an inverse correlation between DNMT1 and miR-217 expression was observed in skin tissues and different-aged fibroblasts.
Finally , apart from two items , the MAPDAQ-G is understood by nurses and can be interpreted consistently.
Finally , apoptotic signals including processed caspase-8 , caspase-7 , poly ADP-ribose polymerase , Bax and Bcl-2 were examined.
Finally , approaches in which the three agencies support CER involving the aging population are set forth and opportunities for future CER research outlined.
Finally , a reduction in connective tissue elasticity and changes of the axial skeleton lead to various modifications of the swallowing pattern with advanced age.
Finally , as a signature for long life we identified @number@ microbial genes that significantly correlated with ageing.
Finally , as the poorly educated age , the negative health effects of their parents ' low educational attainment get worse.
Finally , as Treasury debt securities ( trust fund assets ) are redeemed in the future , they will just be replaced with public debt.
Finally , a total of @number@ participants who completed all the sessions and the three measurements entered the final analysis.
Finally , atrophy was found to accelerate with increasing age , and this was especially prominent in areas vulnerable to AD.
Finally , authors discuss potential targets and strategies of aging research in China.
Finally , a WNT luciferase reporter assay was performed and showed no activation of the β-catenin dependent pathway by Wnt16.
Finally , BAI did not accurately predict fat% in people with a fat% below @percent@.
Finally , BAI is not accurate in people with extremely low or high body fat percentages.
Finally , based on this literature review , a number of key challenges have been outlined for data mining methods in health monitoring systems.
Finally , because of the similarities of the vascular pathomechanisms activated , obesity can be considered to cause accelerated , ' premature ' vascular aging.
Finally , before hypometabolism , a hypermetabolic phase was identified for some cortical regions , including the precuneus and posterior cingulate.
Finally , BNIP3 and NIX are implicated in mitochondrial quality control , which is important in aging and degenerative disease.
Finally , both compounds inhibited cell growth via cell cycle arrest.
Finally , both microarrays and ELISA revealed different expression of several genes and soluble factors in UC-MSCs as compared with other MSCs.
Finally , botulinum toxin acts by reducing certain muscle contractions to smooth out expression lines and folds induced by facial dynamics.
Finally , BrainAGE predicted both patient status as well as negative and disorganized symptoms.
Finally , butein also suppressed the RANKL-induced differentiation of macrophages to osteoclasts in a dose-dependent and time-dependent manner.
Finally , Ca2 + oscillations induced by low dose of bradykinin in old cells exhibited lower spike frequency , but higher overall levels.
Finally , CA3 neuron loss was detected @number@ months post-injection of AD-Tau but not CBD-Tau.
Finally , calcium imaging was performed and we identified small amplitude , diastolic and systolic calcium transients confirming a deficiency in calcium handling.
Finally , cancer survivors often experience significant health issues for many years after the treatment has subsided.
Finally , caregivers needing higher levels of familial and / or social support had also higher levels of distress.
Finally , caspase-8 is involved in glucocortocoid-induced thymocyte apoptosis through an activation loop with the protein GILZ.
Finally , CBD-tau- and PSP-tau-injected mice showed spatiotemporal transmission of glial tau pathology , suggesting glial tau transmission contributes to the progression of tauopathies.
Finally , CC tissue loss was also associated with impairment of motor function.
Finally , CGIs associated with distinctive biological processes , such as diseases , aging , and imprinting , occur disproportionately across CGI clusters.
Finally , challenges to the implementation of an individualized therapy approach in the context of precision medicine are discussed.
Finally , changes in the fidelity and efficiency of mitochondrial DNA repair are likely to be involved in DNA damage accumulation , disease and aging.
Finally , CMV-seropositivity is associated with decreased percentages of individuals responding to the vaccine in both young and elderly individuals.
Finally , co-expression of mHtt blocks Rhes-induced autophagy activation.
Finally , collaborative efforts with international medical institutions are recommended.
Finally , comparison of FCD1 and FCD2 exponential models suggested that the FCD1 phenotype is significantly more severe ( P = @number@ ) .
Finally , comparisons of epigenomes from monozygotic twins help dissect genetic and environmental influences on human phenotypes and longitudinal comparisons reveal aging-associated epigenomic drift.
Finally , comparisons with previous AoA and MB-CDI norms support the validity of the present estimations.
Finally , complex regional and topological patterns of associations between changes in surface area and thickness were observed.
Finally , compromised proteasome function blocks lifespan extension in both strains.
Finally , contactin-2 levels were decreased in Alzheimer's disease brain samples correlating inversely with elevated BACE1 levels in the same samples.
Finally , cortical vBMD was unrelated to vascular calcification and valvular calcification in women and men.
Finally , CSB knockdown resulted in reduced incision of 8-hydroxyguanine in a DNA bubble structure using whole cell extracts.
Finally , CSF apoE levels , but not plasma apoE levels , correlated with CSF β-amyloid levels.
Finally , current vascular measurements are still crude and may not be sufficient to cover the different aspects of EVA in obesity.
Finally , data were weighted for non-response to see if this improved generalizability.
Finally , deep sensation of vibration and proprioception is decreased with age as well as superficial sensation ( touch , temperature , pain ) .
Finally , defects in chondrogenesis are partially reversed by periodic incubation with ROS-scavenger agent that mimics MnSODM effect.
Finally , diffusion-weighted imaging ( DWI ) has been used to compare structural connectivity.
Finally , Drosophila in vivo studies show that Hrp38 deficiency produces locomotive defects and life span shortening in TDP-43 with and without animals.
Finally , due to the significant impact on patient progress and medical costs , special emphasis is given to the low therapeutic adherence levels observed.
Finally , during human senescence , the incidence declines for all cancers.
Finally , educational programs for CNAs that include empathy-inducing scenarios could potentially improve the care provided by CNAs when dealing with residents ' pain.
Finally , effective interventions to enhance wisdom need to be developed and tested.
Finally , elderly show the impaired ability of memory B cells to differentiate into plasma cells.
Finally , epistasis analysis mapped these Spartan functions to the RAD6-RAD18 DNA damage tolerance pathway.
Finally , ERK1 / 2 was inhibited , but tau phosphorylation was not altered in Mek1- / - mice.
Finally , examples reported here highlight the importance of suspending publication of meta-analyses based on unstandardized 25 ( OH ) D results.
Finally , exercise intervention confirmed that S subjects are able to recover MitoVd , ATPmax , and specific transcription factors.
Finally , exercise in the water was more effective in restoring HRV during recovery , with greater effects in the untreated hypertensive group.
Finally , experimentally altered PU.1 levels affected the expression of mouse orthologs of many AD risk genes and the phagocytic activity of mouse microglial cells.
Finally , experimental subjects were tested throughout development and aging at 2- , 8- and 18-months for behavioral phenotype.
Finally , exploiting the TCL1-AKT interaction , peptide-based TCL1-interphase mimics were potent in steric AKT antagonization and in reducing CLL cell survival.
Finally , exploratory analyses of sex differences in the relationships between regional cerebellar volume , age , and cognition were investigated.
Finally , factors known to affect PF , such as sleep , depression , fatigue , and self-efficacy , are discussed.
Finally , favorable health-related quality of life was inversely associated with mortality ( HR @number@ 95%CI @number@ @number@ P < @number@ ) .
Finally , flanker congruency produced earlier modulation of ERPs amplitude with age.
Finally , flow cytometry revealed that IFN-γ arrested the cells in the G1 / S phase.
Finally , for young adults only , strategy combination was larger following problems violating rules than after problems respecting rules.
Finally , frequent snoring was significantly more common in males than females.
Finally , future directions for policy , research , and practice are proposed in order to increase Chinese elders ' civic engagement.
Finally , future directions in practice and research are presented to develop additional methods of support for older adults with SMI and their families.
Finally , future directions in using a C. elegans-based model for discovering bioactive compounds for health promotion are discussed.
Finally , future perspectives of this research are discussed.
Finally , gender differences are discussed in terms of the patriarchal culture of Korean society.
Finally , gender-related differences were significant in the response time of the subjects , finding males response faster.
Finally , genetic instability is investigated in CD34 + cells of a patient with acute myeloid leukemia by immunofluorescence microscopy of γH2AX and 53BP1.
Finally , given the importance of sagittal alignment and the role of osteotomies in treatment for deformity , the need for future research becomes apparent.
Finally , goal disengagement buffered the association of functional disability with increases in depressive symptoms.
Finally , growth-related AR patterns independently predicted well-being beyond the effects of traits and demographic factors.
Finally , guidelines for nurses working with older adults who are facing this developmental stage of life are provided.
Finally , HDAC7 was involved in the formation of other hippocampal-dependent memories , including the Morris water maze and object location test.
Finally , hierarchical regression modelling substantiated this double dissociation.
Finally , hierarchies of knowledge contributed to systemic exclusions and the perception that \ "careworkers ' don't have a voice. \ "
Finally , higher AWT is associated with a lower level of pulmonary function , even in this population of healthy subjects.
Finally , high-volume centers and hospitals without palliative care units reported greater-than-average rates of chemotherapy near the end of life.
Finally , hippocampal activity , correlated with individual memory scores , suggesting a compensatory mechanism in patients with preserved memory.
Finally , HIV + IRP + individuals had a significantly shorter mean lymphocyte telomere length than their non-IRP counterparts ( p = @number@ ) .
Finally , HS-1793 inhibited hypoxia-induced PC-3 cell migration.
Finally , I characterize the @number@ CpG sites that together form an aging clock in terms of chromatin states and tissue variance.
Finally , improvement of endogenous defenses induced in RSV-pretreated reconstructed skin ensured protection against the toxic oxidative effects of cumene hydroperoxide ( CHP ) .
Finally , improvements in relational integration performance were associated with greater modulatory and weaker fixed PFC connectivity.
Finally , in both prefrontal and MTL regions , white-matter decline and success-related activations occurred in close proximity and were negatively correlated.
Finally , in both studies there were no significant relationships with regard to Agreeableness and Conscientiousness.
Finally , incubation of cells with PD-L1-neutralizing antibodies significantly decreased apoptosis of Aβ-specific CD4 ( + ) T lymphocytes.
Finally , individuals with high serum levels of NE had similar elevated gene expressions observed in vitro compared to the low NE group.
Finally , in half of the countries , one-fifth or more of chronically ill adults were caregivers themselves.
Finally , inhibition of TRPC6 , either pharmacologically or genetically , attenuates HPV , hypoxia-enhanced SOCE , and the development of HPH.
Finally , in murine models , Eruca sativa Mill. aqueous extract showed significant antithrombotic activity and a slight effect on bleeding time.
Finally , in older sedentary men , the rapid vasodilation appears not to involve the sympathetic system.
Finally , in simulated populations where menopause had already evolved , we found that reduced post-reproductive lifespan lead to reduced children's fertility and grandchildren's survival.
Finally , institutions and agencies must adapt and become inclusive of the spectrum of diverse individuals found across the changing social landscape.
Finally , interesting drug targets for the prevention and treatment of osteoporosis were revealed.
Finally , interviewees described the dynamics of stigma as all-consuming , relegating them to the ' quagmire of an HIV ghetto'.
Finally , in the third time window , inhibition has primarily been associated with the N400 and N450 ERP components.
Finally , in this article a new definition of aging is put forward.
Finally , investigation of the underlying mechanisms may be clinicall helpful in individualizing the appropriate intervention.
Finally , it appears that the mutation bias in V genes indeed relates to their long-term survival in actual human repertoires.
Finally , it is often associated with increased alcohol consumption.
Finally , it is remarked that all properties of HDPE / HA is dependent on the irradiation dose and accelerated aging.
Finally , it offers practical implications for the healthcare industry.
Finally , it offers suggestions for expanding inquiry into this underinvestigated corner of aging research.
Finally , it would be useful to know the extent to which these predictors can worsen or aggravate existing Alzheimer's disease.
Finally , I will discuss the functional significance of the default system and consider the possibility of internal thought processes in the monkey.
Finally , klotho inhibited IGF-1 pathway activation and inhibited transcriptional activity of the estrogen receptor.
Finally , lonelier individuals reported more positive affective experiences when they were with their spouses than when they were not.
Finally , longitudinal series of X-rays of @number@ Japanese children are used to derive the precision of the measurements.
Finally , loss of DBC1 in mice leads to higher susceptibility to experimental autoimmune myasthenia gravis.
Finally , lower executive function was associated with weaker PLS in men ( OR = @number@ p = @number@ ) .
Finally , M1-specific CD8 ( + ) T cells that underwent more expansions had significantly longer telomeres than cells with fewer divisions.
Finally , MAF14001 decreased the tau phosphorylation ( Ser-202 ) induced by Aβ.
Finally , management of cardiac dysfunction in the trauma patient includes an appreciation of the inherent effects of trauma on cardiac function.
Finally , many aged patients suffer from unintentional poor compliance.
Finally , MCI participants took significantly longer to complete the task and adhered less to their formulated plans during task completion.
Finally , mediation analysis was performed to investigate whether DNA methylation of cg21325723 mediates this gene-environment interaction on the risk of developing of ACPA-positive RA.
Finally , meta-analysis included population-based epidemiological studies.
Finally , methodological issues involved in this type of research and potential applications to applied settings are discussed.
Finally , methods in the construction of the PET networks revealed reasonable robustness.
Finally , miR-339-5p levels were found to be significantly reduced in brain specimens isolated from AD patients as compared with age-matched controls.
Finally , mitophagy has been linked to aging , as impaired macroautophagy over time promotes mitochondrial dysfunction associated with the aging process.
Finally , molecular biologists have found new age-associated genes by showing changes in longevity of genetically manipulated mice.
Finally , molecular modeling of PI3K-FK228 analogs and analyses of the binding affinities identified the structure that defines potency for PI3K inhibitory activity.
Finally , more recent studies suggest that neuronal death in Alzheimer's disease may also be associated with TNAP function on certain brain-specific phosphoproteins.
Finally , morphological changes and membrane fluctuations were recorded using label-free digital holographic microscopy.
Finally , most psychological determinants should be considered within a larger framework of other multi-level determinants that may interact or mediate some of the effects.
Finally , mouse embryonic fibroblasts lacking a functional Wrn helicase inhibited the immortalization of Safb1-null cells.
Finally , mTOR signalling has also been linked to human ageing , and crosstalk between Wnt and mTOR signalling may influence colonic tumourigenesis.
Finally , multilocular thymic cyst manifests as a cystic anterior mediastinal mass.
Finally , multiple group comparison performed through structural equation modelling also provided support for the negative association between perceived discrimination and active aging proposed.
Finally , mutation of hypersuccinylated residues K83 and K310 on HMGCS2 to glutamic acid strongly inhibits enzymatic activity.
Finally , neurodegeneration was not specific to layer V cortical neurons perfectly in line with the current model of disease spreading in ALS.
Finally , no additional effect of age on the diminished task performance in participants with chronic pain was observed.
Finally , none of the FTD patients harbored this genetic variant.
Finally , none of these parameters showed a significant association with voxelwise [ ( @number@ ) I ] FP-CIT uptake.
Finally , nothing in our recommendations replaces meticulous attention to US FDA guidelines in the package insert of each drug.
Finally , novel aspects of adipose tissue biology and their involvement in the ageing process are discussed.
Finally , @number@ placebo-controlled studies demonstrated the efficacy of incobotulinumtoxinA for treating GFLs and upper facial lines.
Finally , @number@ studies identified factors associated with the presence of potential DIs.
Finally , @number@ subjects with complete information for components of MetS in the three years were included in the study.
Finally , only half of the GP group agreed that vascular surgeons treat patients with abdominal aortic aneurysms.
Finally , only @number@ articles fulfilled the inclusion criteria and were included in this review.
Finally , our analysis of the tubular network structure provides valuable data to improve current numerical models.
Finally , our analysis of α asymmetry revealed greater relative right frontal activity.
Finally , our data showed that exercise had a stronger influence on scale invariance than the effect of age.
Finally , our data showed that SirT1 modulated the enrichment of H3K9 tri-methylation around the SMC gene-promoter regions.
Finally , our data suggest that the well-documented age-related decline in peripheral reading ability is not due to age-related changes in visual crowding.
Finally , our results also show that EndoPAT may be a useful noninvasive tool to assess the vascular reactivity.
Finally , our results indicated that the palatability of sake was influenced by the dish eaten just before drinking.
Finally , outstanding questions concerning retinal blood flow in health and disease are discussed.
Finally , oxidant injury of brain endothelial cells in culture , resulting in expression of inflammatory proteins , is mitigated by sunitinib.
Finally , p53 mutations correlated with alterations in ETC subunit composition and activity in primary glioma-initiating neural stem cells.
Finally , participants were requested to inhibit overflow with , and then without visual feedback , or vice versa.
Finally , pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum.
Finally , patients with MCI also showed a generalized problem solving deficit that affected even BADL.
Finally , people with multimorbidity lived @percent@ of their remaining years of life with disability ( median @number@ years ) .
Finally , perseverations were associated with nonmemory indexes , thereby underscoring the nonverbal nature of this error in OAs and individuals with AD.
Finally , pharmacological effects of dammarane triterpenoids should be further studied.
Finally , Phase II field testing of the intervention was carried out.
Finally , polypharmacy is associated with an increased risk for CKD in the elderly.
Finally potential mechanism-based adverse effects of these treatments and the strategies to tackle these problems will be discussed.
Finally , practice effects , which were influenced by age , were found between administration times.
Finally , preexisting dermatoses may be exacerbated by irradiation from the sun , as in systemic lupus erythematosus or Darier disease.
Finally pre-existing strain-specific NAb decreased the boosting of CD4 T cell responses.
Finally , protein and calcium intake should be considered in the prevention or treatment of the chronic diseases osteoporosis and sarcopenia.
Finally , proteinuria-induced BiP induction in PTCs was diminished in kidney specimens from elderly patients.
Finally , public health approaches to minimize falls risk and consequent demand on health care resources are suggested.
Finally , putative neural pathways are discussed.
Finally , RalGAP suppression caused mTORC1-dependent pancreatic tumor cell invasion.
Finally , rating of perceived exertion during eccentric exercise was often significantly lower than during traditional resistance exercise.
Finally , recent insights point toward an important role of autophagy in the paracrine regulation of vasoactive substances from the endothelium.
Finally , reduction or deletion of IFNα receptor @number@ inhibited IFN signaling and increased the life-span of SOD1 ( G93A ) mice.
Finally , relations reflected individual differences over and above chronological age.
Finally , requiring an employer's recommendation to obtain permanent residency may constrain foreign workers from registering complaints or leaving suboptimal employment situations.
Finally , results from the one Norwegian study suggest significantly decreased mortality risks among foreign-born , to be explored in further research.
Finally , results of mediated moderation analyses showed that leader-member exchange quality mediated these moderating effects.
Finally , results of the content analysis also suggest that implicit ageism is indeed reflected in interpersonal communication between frail elders and caregivers.
Finally , RGFP963 , but not RGFP966 , rescued memory in a mouse model of Alzheimer's Disease.
Finally , RNA immunoprecipitation demonstrates that ANRIL binds to SUZ12 in vivo.
Finally , rs6656401 and rs3818361 were strongly associated with CR1 length polymorphism ( p < @number@ ) .
Finally , several adhesion molecules and gangliosides are key determinants of axon survival , probably by mediating axon-glia interactions.
Finally , severity of overall WMHs was independently associated with LOS , which was similar to the results of DWMHs.
Finally , significant modulation correlations were found between ERD% and hemodynamic measures despite the absence of significant amplitude correlations.
Finally , SIRT6 mRNA and protein levels are reduced in patients with Alzheimer's disease.
Finally , six older persons participated in three pilot studies and thirty older persons participated in the preliminary study to identify construct validity evidence.
Finally , SNP regulated the expression of proteins related to the cellular cycle ; the NO donor decreased bcl-2 , mcl-1 and procaspase-3 protein expression.
Finally , some positive experiences are reported in the prevention of falls in elderly and of sexually-transmitted diseases.
Finally , special considerations for pediatric studies are provided.
Finally , sputum production , articulation and phonation , and voluntary saliva swallowing were strongly associated with swallowing function test results.
Finally , strawberry intake significant decrease ( P < .05 ) the number of activated platelets , compared to both baseline and washout values.
Finally , streptozotocin-induced diabetes showed more senescent cells in the aortic endothelium of aged rats compared with age-matched control and insulin-treated animals.
Finally , studies are presented linking BubR1 dysfunction or misregulation to aging and human disease , particularly cancer.
Finally , Study @number@ showed that simply expecting to take a memory test subjectively aged older adults.
Finally , superoxide dismutase ( SOD ) and SIRT1 activity assays showed that phloridzin notably increased the activity of SOD and SIRT1.
Finally , susceptibility of bmMSCs and ucMSCs to NK-cell lysis remained stable.
Finally , T21-derived neurons show significantly higher number of DNA double-strand breaks than isogenic D21 controls.
Finally , Tat and / or Nef decreased the MSC potential of osteoblastic differentiation.
Finally , the accomplishments and initiatives reported by state respondents related to supporting informal caregivers are also explained.
Finally , the age-related loss of trabecular elements appeared to result in a compensatory hypertrophy of vertical trabeculae in women , but not in men.
Finally , the alarmins S100A8 and @number@ have long been considered as markers of inflammatory joint destruction , but now appear to be catabolic mediators.
Finally , the area under the curve shows a potential that is @percent@ ( men ) to @percent@ ( women ) larger for the no.
Finally , the association between care receiver cognitive functioning and caregiver role strain was influenced by the level of mutuality between caregiver and care receiver.
Finally , the authors also evaluated the relationship between nasal bone height and maxillary bone thickness in the lacrimal sac fossa.
Finally , the average telomerase activity was @percent@ higher in the subjects taking this food supplement.
Finally , the bioactivity of His-tagged hLA was examined using STAT3 phosphorylation and receptivity of human endometrial ECC-1 cells.
Finally , the calpain-induced fragment can be observed both in Alzheimer's disease brains and in control normal human brains.
Finally , the contribution of peroxisomal dysfunctions to the alterations of brain functions during aging and to the development of Alzheimer's disease is considered.
Finally , the COURAGE-SNI score was obtained as the sum of weighted information calculated by the item response theory procedure for every aforementioned component.
Finally , the cumulative growth curve and senescence of the hMSCs were evaluated in order to assess the aging process.
Finally , the current methodologies utilized for measuring O2 ( -• ) / H2O2 in isolated mitochondria , cell culture and in vivo are reviewed.
Finally , the cytotoxicity assay was simplified by measuring luciferase activity using lineage-specific luciferase reporter iPSC lines which were generated from the parental iPSC line.
Finally , the data were fitted to three polynomial models.
Finally , the details of the @number@ revision of \ "Labour Standards for Women \ " are described.
Finally , the development of small-molecule mitochondrial-targeted therapeutic approaches is reviewed.
Finally , the diagnostic and prognostic utility of measuring urinary glcUMOD concentration was examined.
Finally , the differential item functioning ( DIF ) was examined to measure group equivalence associated with age and disease's severity.
Finally , the early Pe showed a reduction in amplitude and an increase in latency for middle-aged compared to young adults.
Finally , the effect of AG11 on tubulin polymerization in vitro and microtubule distribution across the cells was investigated.
Finally , the effect of predictability in reading times on the target word was larger for older adults than for young adults.
Finally , the importance of treating anorexia to achieve health benefits in frail elders is highlighted.
Finally , the incidence of abnormal neurological outcomes ranged from @number@ to @percent@ in DCTA and from @number@ to @percent@ in MCTA triplets.
Finally the inhibition of Aβ neurotoxicity with domain V is synergistic with inhibitors of αv integrin and β1 integrin.
Finally , the interaction of masculine gender scripts within these themes was considered.
Finally , the lifelong evolution of IGF-1 serum levels showed significant differences throughout life until aging in mice.
Finally , the limitations of this technology from the standpoint of reprogramming efficiency and therapeutic safety are discussed.
Finally , the mechanisms that are putatively responsible for the procognitive effects of 5-HT6 receptor ligands are briefly discussed.
Finally , the obtained results are in accordance with the hypothesis that circumferential-to-axial stiffness ratio is the quantity relatively constant within this cycle.
Finally , the OHDHA concentrations used here did not produce relevant toxicity in zebrafish embryos in vivo.
Finally , the onset of an authentic PPS is possible.
Finally , the overall quality of the AMW was noted to be better predicted by PLSR than PCR.
Finally , the paradigm shift needed to fully institute tailored treatments for people and families dealing with these symptoms in the community is discussed.
Finally , the penetration of the active substance from creams and ointments may also change with age.
Finally , the physical health of the spousal caregiver is related to depressive symptoms at follow-up.
Finally , the possibility of targeting miRNAs as a therapeutic approach for the treatment of IPF is discussed.
Finally , the potential therapeutic strategies of pharmacological PARP activity inhibition for the treatment of cancer-induced cachexia are also being described in this review.
Finally , the practical importance of studying and assessing awareness from both theoretical and clinical angles is emphasized.
Finally the recently described roles of these pathways in cancer stem cells , cellular senescence and aging will be evaluated.
Finally , the reduction of melatonin observed with aging , may indicate the presence of an \ "age clock \ ".
Finally , there is a need for greater methodological uniformity and the use of measures that are validated for an older population.
Finally , there is evidence to suggest that wife sanctification influences how men refer to their new women friends.
Finally , there is little evidence that testosterone adds to existing erythropoietin agents in the treatment of anemia in ESRD.
Finally , the relationship between AD and susceptibility to or exacerbation of postoperative cognitive dysfunction ( POCD ) is not well understood.
Finally , the relative increase of memTreg cells in elderly individuals was associated with poor responses to influenza vaccination.
Finally , the residual reserve variable moderated the negative impact of memory variance explained by brain pathology on language decline.
Finally , the results may have implications for potential clinical interventions in addressing late-life depression.
Finally , there was an inverse association between care recipients ' cognitive functioning and family members ' satisfaction.
Finally , there were @number@ trials that met the inclusion standard.
Finally , the risk of early erlotinib discontinuation was increased by @number@ in older pts.
Finally , the role of ERα / ERβ on rapid E2 signaling and synaptogenesis as it relates to hippocampal aging is discussed.
Finally , the route of NPs administration and the future prospects will be discussed.
Finally , the scale appears to be sensitive to cognitive differences within the normal spectrum.
Finally , these sex differences in aging trajectories were robust to choice of preprocessing strategy , such as global signal regression.
Finally , the study's findings suggest that memory and attention contribute to older adults ' story processing performance.
Finally , the subjects were categorized into two groups according to having CD or not.
Finally , the thickness of the epidermis was significantly increased in actinic keratoses compared with the control.
Finally , the training also significantly ameliorated AD-like tau and amyloid pathologies.
Finally , the translated instrument was revised and improved using discussions , consultations , and pilot study.
Finally , the treatment of heat-related illnesses and their prevention are explained.
Finally , the use of the pinch gauge to assess long-term change in upper limb ability seems preferable to the three other measurements.
Finally , this paper proposes a concerted and robust mobilization of forces in order to move from evidence-based agenda setting into active policy implementation.
Finally this review concludes with possible strategies to improve the ability of the senescent immune system to respond to vaccination.
Finally , this review discusses some of the challenges and opportunities of translating research findings from animals to humans.
Finally , this review examines new perspectives for regeneration , rejuvenation , and treatment of age-related decline of stem cell function.
Finally , this review will focus on some specific EEG features such as the electrical epileptoid activity observed under sevoflurane anesthesia.
Finally , to investigate operator-dependent causes , sections were cut by different operators blinded to aim.
Finally , tomato products may be used as a functional ingredient adding antiplatelet activities to processed foods.
Finally , training adaptations and health implications are briefly discussed.
Finally , training gains generalized to group and individual level benefits in aspects of working memory and sustained attention.
Finally , transgenic disruptions in GH signaling pathways affect neuron and astrocyte cell numbers during development and during adulthood.
Finally , transgenic mice that overexpress human TRX80 specifically in macrophages of apoE CONCLUSIONS : TRX80 showed an age-dependent increase in human plasma.
Finally , treatment of mice with ALA enhanced fasting-induced up-regulation of CREBH and FGF21 in the liver and inhibited feeding-induced suppression of their expression.
Finally , TRUS may reveal prostate and SV echo-texture abnormalities suggestive of inflammation or SV stasis.
Finally , understanding the role of highlights and shadows on the impact of aging is addressed.
Finally , visual deteriorations might also , secondarily , induce strained postures and musculoskeletal symptoms , pain and injury.
Finally , volume density of the FS cell significantly correlated with LH cells area and nucleocytoplasmic ratio.
Finally , VZV-RCF was higher in depressed patients treated with antidepressant medications as compared to untreated depressed patients.
Finally , we address the option of applying exercise mimetics as an alternative for disabled old people.
Finally , we also found low rms ( 5±2% ) when comparing simulated pressure in the proximal aortic location against tonometric carotid pressure curves.
Finally , we also obtained twelve bone samples from cadavers ' skulls.
Finally , we also review the current data on CD200-CD200R interaction in AD , as well as , in the aging brain.
Finally , we analyzed repeatability of the answers within a @number@ weeks interval.
Finally , we analyzed the findings in terms of all the memories recalled versus the first memory from each life-period only.
Finally , we ask : can scientific inquiry preserve its integrity and objectivity under social pressure ?
Finally , we assessed laterality and age-related WM changes in @number@ normal subjects aged @number@ to @number@ years using these tractography-derived tract segmentations.
Finally , we assessed @number@ studies involving @number@ cases and @number@ controls.
Finally , we assessed whether brain-penetrant compounds could stabilize mouse CNS MTs.
Finally , we attempt to put into perspective the necessary balance between the expected benefits and risks , especially in the adjuvant setting.
Finally , we comment on the screening and management , cost and side effects of therapy as it applies to an aging population.
Finally , we compared path coefficients of the dataset imputed by ipsative imputation with those by multiple imputation.
Finally , we conclude by discussing the future of animal models in aging research.
Finally , we conclude that four or five oncogenic mutations are sufficient for the formation of glioma.
Finally , we conclude with some suggestions for future research in the area of retirement that would be particularly relevant for psychologists to consider.
Finally , we confirmed a significant up-regulation of IgE responses to BP180 in the patients with pemphigoid.
Finally , we confirm the finding by showing a positive correlation between miR-155 and thiamine level in @number@ triple negative breast tumors.
Finally , we consider the potential medical implications , and future potential in the application of lncRNAs as therapeutic targets and diagnostic markers.
Finally , we consider the significance of the situational as cultural in relation to holistic interpretation of narrative.
Finally , we define the specific morphological process as the remainder of the observed anatomy after the removal of the estimated normal aging process.
Finally , we demonstrated that miR-125b action requires the ' seed ' sequence in @number@'UTR of CCL4.
Finally , we demonstrated that older adults with greater overall WM microstructure were those showing more LI-PA and MV-PA and greater SDBOLD.
Finally , we demonstrated that phosphorylation of Hsp27 is irrelevant to SFN-induced proteasome activation.
Finally , we demonstrated that resveratrol can delay degeneration of crushed nerves in vivo.
Finally , we demonstrated that the infusion of adenovirus encoding RORα into arteries suppressed neointima formation after balloon injury in rats.
Finally , we demonstrate that Rheb levels are down-regulated in the AD brain , which is consistent with an increased BACE1 expression.
Finally , we demonstrate that the proposed algorithm is able to detect differential effects of AD on the brainstem structures.
Finally , we demonstrate the validity of these latent variables as biomarkers by using them for classification of ADHD in @number@ patients.
Finally , we describe further risk factors and donor-recipient selection under the scope of old donor organs and include our institutional experience and policy.
Finally , we describe human studies associating variants on pancreatic-expressed PAX genes with pancreatic diseases.
Finally , we describe the connection between premature aging syndromes and the nuclear lamina , a filamentous protein network which underlies the nuclear envelope.
Finally , we describe the patterns of Barx gene expression in vivo and the phenotypes of various Barx gene perturbation models including null mice.
Finally , we detail the potential involvement of the SC niche in tissue degeneration , with a particular emphasis on aging and cancer.
Finally , we determined by von Kossa staining that TREML4 colocalizes with areas of microcalcification within coronary plaques.
Finally , we develop a fluorescence-activated cell-sorting strategy to isolate interneuron progenitors from SFEBs to allow development of a purified population of these cells.
Finally we developed readily applicable score charts for the calculation of outcome probabilities.
Finally , we direct researchers to additional data resources for understanding aging in Sweden in greater depth.
Finally , we discuss aging interventions that have been observed to impact cardiac health outcomes.
Finally , we discuss current developments that can be applied to control and prevent bacterial food contamination.
Finally , we discuss factors that are hypothesized to cause or modify the disease.
Finally , we discuss future studies that will hopefully lead to a comprehensive understanding of the miRNA pathway in stem cells.
Finally , we discuss how dietary carbohydrates influence health and aging in humans.
Finally , we discuss how new technological advances could further progress the research field.
Finally , we discuss key molecular pathways of interest with a focus on therapeutic targets that warrant further investigation.
Finally , we discuss possible therapeutic interventions to improve proteostasis and prevent pathological brain aging.
Finally , we discuss progress in designing therapeutic strategies that manipulate the cellular redox environment to restrict age-associated pathology.
Finally , we discuss recent findings that broaden therapeutic options for targeting this important mechanical signaling pathway in vascular pathogenesis.
Finally , we discuss recent progress in utilizing protein prenylation for site-specific protein labeling for various biotechnology applications.
Finally , we discuss schizophrenia and look into abnormalities in circuit function and neurotransmitter systems that contribute to memory impairment in this illness.
Finally , we discuss some of the issues relating neurogenesis to pathophysiology and aging.
Finally , we discuss some recent insights from interventions in NSC aging that could eventually translate into therapies for healthy brain aging.
Finally , we discuss special issues affecting pain management in older adults , including dementia , polypharmacy , and barriers to accessing adequate pain care.
Finally , we discuss the feasibility of a model with fewer assumptions.
Finally , we discuss the future challenges related to the continued expansion of ambulatory surgery practice in this growing segment of our surgical population.
Finally , we discuss the future directions and applications of bioinformatics that can provide greater insight into the relationship between these two diseases.
Finally , we discuss the implications of this model for understanding basic mechanisms of brain aging and for the future investigation of therapeutic approaches.
Finally , we discuss the possible implications for HIV-infected persons , with particular reference to ageing.
Finally , we discuss the possible role of positive technologies for healthy living and active ageing by presenting different practical applications of this approach.
Finally , we discuss the potential benefits that understanding EMT may bring to the field of chronic respiratory disease.
Finally , we discuss the potential of boosting the PQC system as an innovative therapeutic target to treat cardiac disease in the elderly.
Finally , we discuss the relationship between systems consolidation and memory precision.
Finally , we discuss the relevance of this work in light of ongoing clinical trials that study the effectiveness of complement inhibitors against AMD.
Finally , we discuss the therapeutic and biomarker potential of lncRNAs.
Finally , we discuss whether liquid biopsies are ready to be used in routine clinical practice.
Finally , we evaluated EIF2AK3 coding variants that influence PERK activation.
Finally , we examined how personality style may interact with cognitive variables and age in decision making.
Finally , we examined possible mechanisms of neuroselection.
Finally , we examined protein-protein interactions using a protein microarray method to screen proteins with a high affinity for hLRG.
Finally , we examined the relation of telomere length to extensiveness of CAC.
Finally , we examined the status of such priming in aging.
Finally , we examined the temporal property of the primary submovement and its age-related changes.
Finally , we examine the covariation of the two over the full range of mineralization stages.
Finally , we examine the existing state of monitoring for metformin efficacy and side effects and discuss prospective future clinical uses.
Finally , we explore how the already stressed aged brain psychologically and physiologically responds to external stressors.
Finally , we explore the potential promise of these findings for future therapeutic applications.
Finally , we exposed SH-SY5Y cells to β-amyloid ( Aβ ) 42 which triggered elevation of both AChE and PS1 levels.
Finally , we find increasing mortality-related expenditures over time.
Finally , we find that SIRT3 overexpression represses glycolysis and proliferation in breast cancer cells , providing a metabolic mechanism for tumor suppression.
Finally , we focus on the need to characterize AD-specific retinal Aβ to differentiate Aβ found in some eye diseases.
Finally , we formulate a \ "metabolic state hypothesis \ " linking mitochondrial state and cellular metabolism to the stage of differentiation.
Finally , we found no association between our measures of attention across groups , suggesting negligible overlap between INT , NP , and IOR.
Finally , we found several studies including cognitive measures in the operational definitions of frailty.
Finally , we found that deoxygenation-mediated ATP release from isolated erythrocytes was essentially nonexistent in older adults.
Finally , we found that KLF4 regulates autophagy flux through transcriptional regulation of a broad array of autophagy genes in cardiomyocytes.
Finally , we found that the level of p16INK4A expression significantly increased supporting cellular senescence process associated to our model.
Finally , we have considered whether interfering in chondrocyte apoptosis or promoting autophagy could constitute therapeutic strategies to impede OA progression.
Finally , we have evaluated the effect of the different drug combinations on this cellular model.
Finally , we have provided a synthesis of the differential iron accumulation and toxicity in glia and neurons from reported iron loading paradigms.
Finally , we highlight several challenging issues and areas for future research in this rapidly growing field.
Finally , we identified marked changes to the elastic fibre , fibrillin-rich niche and the pericellular matrix.
Finally , we identified @number@ dmCpG sites that perform well in discriminating young from old samples.
Finally , we identify a number of areas where existing cognitive aging research can inform studies on cognitive performance following cancer treatment.
Finally , we identify functional MafG response elements in bile acid metabolism genes using ChIP-seq analysis.
Finally , we look at the future of CRT and how its indications can be expanded to benefit more patients in the future.
Finally , we make recommendations for designing future studies.
Finally , we measured white-matter integrity using diffusion tensor imaging.
Finally , we observed age-associated alterations in the regional characterization in terms of their intra / inter-module connectivity.
Finally , we observed no differences in the amount of HLA antigens expressed among cord blood ECFC , adult ECFC and mesenchymal cells.
Finally , we observed @number@ and @number@ genes for which methylation and expression , respectively , were additionally affected by genetic variation.
Finally , we observed that putative causal genes and down-regulated genes were affected by a loss of genetic control between time points.
Finally , we offer two vital challenges to scientists of today.
Finally , we outline the current evidence for the efficacy of available anti-osteoporotic and proposed antisarcopenic interventions in older persons.
Finally , we passed the specifications to the Information System Unit at the Hospital to develop and integrate the system into the hospital one.
Finally , we performed a cost analysis that estimated savings to be $ 30 , 000-45 , 000 per induction with FLAG.
Finally , we performed a Phase I trial , SAVER-I , to evaluate feasibility and safety of administration in the human condition.
Finally , we point out primary mechanisms of microglia activation , which may comprise therapeutic targets to control neuro-inflammatory and neurodegenerative activity.
Finally , we postulate that FGF21 resistance , similarly to insulin resistance , jeopardizes human healthspan and accelerates the aging process.
Finally , we present a case report of a 65-year-old Caucasian woman suffering from insomnia associated with depression who was successfully treated with sleep deprivation.
Finally , we present a hypothesis for the pathogenesis of early AMD and consider the implications of this model on the development of new therapies.
Finally , we present a summary of recent studies of orexin in neurodegenerative disease.
Finally , we present current data on the use of choroid plexus cells to repair the damaged brain.
Finally , we present nonhuman primates as an important model for translation of mechanisms of delayed aging identified in studies of shorter-lived animals.
Finally , we present some promising anti-AGE strategies that are currently being studied.
Finally , we present the details of our planned drug discovery pipeline.
Finally , we propose a framework to integrate these molecular and physiological data into a composite score that measures biological aging in humans.
Finally , we propose a mechanistic model of lipofuscine formation that can account for the etiopathogenesis of human neuroferritinopathy.
Finally , we propose an age-invariant face recognition algorithm that incorporates the knowledge learned from these observations.
Finally , we propose an agenda both for science and for practice to advance and apply the evidence base for culture-sensitive health communication.
Finally , we propose a novel generative label fusion model that can overcome these drawbacks.
Finally , we propose a scheme for clearly naming the underlying technology associated with any cutaneous energy device.
Finally , we propose , in the context of human evolution , that epigenetic drift may represent a case of epigenetic thrift , or bet-hedging.
Finally , we propose p62 / SQSTM1 as a novel target for aging studies and age-extending interventions.
Finally , we propose pharmacological inhibition of excessive BACE1 activity as an option to mitigate early axonal pathology occurring in AD and other neurological disorders.
Finally , we propose two indexes of MI ability to identify the potential of persons to engage in MI training programs.
Finally , we provide evidence that HIF1 mediates CEACAM6 expression and that CEACAM6 is necessary to recruit ULK1 in a bacteria-containing signaling hub.
Finally , we report a meta-analysis of the result.
Finally , we report an inverse correlation between SIRT6 and TRF2 protein expression levels in a cohort of colon rectal cancer patients.
Finally , we review brain plasticity based on physiologic mechanisms that could underlie mechanisms of neural compensation.
Finally , we review studies that have shown the impact of weight loss , focusing on calorie restriction , iron homeostasis , and immunity.
Finally , we review therapeutic opportunities targeting the RAGE axis as a means to mitigate chronic diseases.
Finally , we show an increase in β3 levels in a subset of tissues during aging.
Finally , we showed that deletion of the intronic enhancer eliminates the ability of Mbnl1 to promote exon inclusion.
Finally , we showed that TNF-α time-dependently induced p300 / c-Fos / c-Jun / ATF2 complex formation in HPAEpiCs.
Finally , we show that early life stress and psychopathology are each associated with these markers of cellular aging.
Finally , we show that human RTEL1 interacts with the shelterin protein TRF1 , providing a potential recruitment mechanism of RTEL1 to telomeres.
Finally , we show that the allele of C3 encoding Gln155 results in resistance to proteolytic inactivation by CFH and CFI.
Finally , we show that these missense mutations abolished the interaction of TRIAD3A with Arc , disrupting Arc ubiquitination , and consequently Arc degradation.
Finally , Western blotting showed that γ-H2AX level significantly increased in CNE1 cells after EBV infection.
Finally , we strongly recommend continuing treatment until complete response demonstrated on imaging and permanent reversal of predisposing factors.
Finally , we suggest that synesthesia is a consequence of global hyperconnectivity.
Finally , we suggest that the clinical applications of Stroop take this factor into account.
Finally , we suggest that U6 snRNA copies can serve as markers of L1 retrotransposition dynamics in mammalian genomes.
Finally , we summarize recent efforts toward the development of targeted therapies for PD and related synucleinopathies.
Finally , we summarize the attempts to prevent PTE in experimental models.
Finally we tested the reliability of our newly developed questionnaire using the best performing set of sedentary activities.
Finally , we touch on cochlear pathologies including noise damage and aging , with an emphasis on where the field might go in the future.
Finally , we urge for collaboration between centers to establish proper clinical standards and to promote better trial results comparison.
Finally , we used functional MRI to acquire resting functional connectivity measures for both groups.
Finally , we used twin methods to create the first map of cortical ROIs based entirely on genetically informative data.
Finally , we will briefly address whether there are problems in the approach.
Finally , we will comment on new approaches that may expand our knowledge of these two molecules in their control of skeletal muscle function.
Finally , we will discuss a potential impact of the human 3D human neural cell culture models on the AD drug-development process.
Finally , we will discuss how similar mechanisms operate in cancer stem cells ( CSCs ) and can mediate resistance to chemo- and radiotherapy.
Finally , we will discuss the implication of aging-related somatopause in relation to the general context of Immunosenescence.
Finally , we will identify the gaps in our knowledge and propose future research avenues.
Finally , we will meta-analyse changes per decade across cohorts , and repeat all analysis stratified by sex , education and APOE genotype.
Finally , we will review the functional connection between polyphenols and mitophagy and provide insight into the underlying mechanisms that potentially govern polyphenol-induced mitophagy.
Finally , we will summarize recent findings that associate MMPs with the development of age-related diseases , such as neurodegenerative disorders.
Finally , we will summarize the current evidence showing that dysfunction of macroautophagy and / or CMA contributes to neuronal diseases.
Finally , when evaluated as summative disability scores , there was little difference in predictive accuracy between the 5-category scale and three alternative scales.
Finally , when the follicle ages and becomes empty of oocyte H ( @number@ ) O ( @number@ ) levels drops significantly.
Finally , xenograft analysis confirmed the deleterious tumor growth effect of MCT1 / MCT4 ablation , an action enhanced by phenformin treatment.
Final sample size for these analyses was @number@ adults.
Final sample size was @number@
Final specimens were observed with the microscope Delta Optical Evolution @number@ at 10× and 40× magnifications.
Final sulfur amino acid intake reached @number@ mg / kg / day.
Financial background can be improved by new theoretical bases of criteria of the palliative treatments.
Financial concerns , aging , and nostalgia for relatives and the motherland were the primary causes of socio-emotional instability.
Financial concerns and low interest among residents / families were identified as major barriers to accessing care.
FINANCIAL DISCLOSURE : Dr. Bissen-Miyajima has received lecture fees from Abbott Medical Optics , Inc.
FINANCIAL DISCLOSURE : No author has a financial or proprietary interest in any material or method mentioned.
FINANCIAL DISCLOSURE : No author has a financial or proprietary interest in any material or method mentioned.
FINANCIAL DISCLOSURE : No author has a financial or proprietary interest in any material or method mentioned.
FINANCIAL DISCLOSURE ( S ) : Proprietary or commercial disclosure may be found after the references.
FINANCIAL DISCLOSURE ( S ) : The author ( s ) have no proprietary or commercial interest in any materials discussed in this article.
FINANCIAL DISCLOSURE ( S ) : The author ( s ) have no proprietary or commercial interest in any materials discussed in this article.
Financial estimates were calculated according to current cost and adjusted according to projected inflation.
Financial insecurity and concurrent substance use were predictors of consistently hazardous alcohol use , and may be modifiable targets for intervention.
Financial planning for retirement is a lifelong process constrained by financial literacy , resources , and competing demands for resources across the life course.
Financial strain and oxidative stress are each predictors of morbidity and mortality , but little research has investigated their relationship.
Financial stress index value was found to be a significant predictor of satisfaction with family relationships.
Finasteride + doxazosin improves scores versus finasteride alone at both short and long term , with mean differences ∼2.0 points for both time points.
Finasteride + doxazosin improves symptoms equally - and clinically - to doxazosin alone.
Finasteride significantly lowers the risk of asthenia , dizziness , ejaculation disorder , and postural hypotension , versus finasteride + terazosin.
Finasteride significantly reduces asthenia , postural hypotension , and dizziness versus terazosin.
Finding additional families with this phenotype will be important to identify the genetic lesion underlying disease.
Finding effective therapeutic agents should be a high priority for medical research.
' Finding Home ' was conceptualised as the core category.
Finding key age markers in normal tissues could help to provide reliable aging predictions in human.
Finding meaning involves looking backwards to sustain continuity with the past and looking forwards to maintain momentum and keep going.
Finding new and effective non-pharmacological treatments for fibromyalgia patients is urgently needed.
Finding possible interventions to age-associated disorders therefore have wide ranging implications.
FINDINGS : 5-year relative survival generally increased steadily over time for all European regions.
Findings alert clinicians to the importance of recognizing red flags and intervening early to interrupt adversarial caregiving.
Findings also indicated an adverse smoking dose / duration response ( i.e. , pack-years ) with total hippocampal and select subfield volumes.
Findings also indicate that the majority of participants want to be economically independent and to keep working until they are unable to do so.
Findings also reveal that the experiences of a subculture in society-African-American elderly women religious-add to theories and definitions of generativity.
Findings also suggest that altered PPARγ signaling may lead to acinar atrophy and development of an age-related hyposecretory MGD.
Findings also suggest that older adults use a range of methods for calculating PA frequency and duration.
Findings also support a relationship between frequency of SCE and increasing age , presence of high-risk factors and co-existing serous cancers.
Findings also underscore the need for wayfinding research in diverse environments.
Findings and Conclusions : Medicare beneficiaries needing LTSS rely predominantly on unpaid care.
Findings are discussed in light of socioemotional selectivity theory and theories on culture and self-construal.
Findings are discussed in relation to the concept of ' responsibilization'.
Findings are discussed in terms of the benefits and limits of teaching older people a strategy in combination with an adaptive WM training.
Findings are discussed in terms of the individual's embeddedness in cultural and life phase contexts when remembering.
Findings are discussed in the context of gendered expectations and the women's bodies.
Findings are discussed in the context of risk for the development of psychiatric disorders , where increased emotional reactivity is particularly apparent.
Findings are discussed in the theoretical context of socioemotional selectivity theory.
Findings are discussed regarding life course and family life cycle perspectives.
Findings are discussed regarding the hypothesised relation between postural synchrony and larger perspective-taking competence.
Findings are evaluated with respect to the relationship between cognitive and functional impairments.
Findings are integrated to explain similarities and differences in older residents ' lived experience of rural and urban settings with regard to age-friendly foci.
Findings based on remember and know judgments suggest that familiarity but not recollection is involved in mediating the repetition effect.
FINDINGS : Better registration of sensory input and greater sensory seeking were related to greater occupational engagement.
FINDINGS : Both absolute and relative accuracy decreased over time during 2MT.
FINDINGS : Care of older adults in SA is in many ways different from and similar to that in the USA.
Findings carry implications for best practices to retain and promote service use among elder victims of abuse.
FINDINGS : Centenarians elected to talk about living as independently as possible , their continuing growth and development and their ongoing close relationships.
FINDINGS : Compared with diabetes mellitus drugs , there is a lack of quantitative surrogate end points among AD drugs.
Findings confirm prior reports of associations between amino acids , lean mass , and fat mass in addition to associations not previously reported.
Findings confirm the effectiveness of adaptation in terms of reduced reactivity to functional losses across increasing level of chronic impairment.
FINDINGS : Data from the project helped to articulate the special and often hidden acts that make up compassionate care.
Findings demonstrated a significant interaction , F ( @number@ @number@ ) = @number@ p < @number@
Findings demonstrated that the OPACS-US is a valid and reliable survey instrument that measures practice experiences and general opinion.
Findings demonstrate how a multicomponent program can have positive benefits for family caregivers.
Findings demonstrate how behavioral and cultural factors-family experiences , religiosity , and denial of retirement-explain the lack of savings and preparedness for retirement.
Findings demonstrate the importance of a soft ( < 700 Pa ) , laminin-containing ECM in regulating healthy , immature NP cells.
FINDINGS : Despite the different legal outcomes , all three court rulings reflect a disregard of known and relevant social gerontology theories of intergenerational relationships.
Findings did not vary by surgical indication for the oophorectomy.
FINDINGS : Different conceptual approaches to providing efficiency of services whilst improving quality of patient care in the context of an ageing population are presented.
FINDINGS : EEE participants enrolled and attended VA appointments at higher rates and within fewer days than those who received AO.
FINDINGS : explanations for deliberative reduction or ceasing of activities reflected a desire to prevent pain exacerbation , thereby avoiding medical intervention.
FINDINGS : Expression of the human Aβ42 in the Drosophila nervous system leads to a drastically shortened life span.
Findings extend the literature demonstrating the negative long-term effects of PTE to include a cellular marker of aging linked to multiple negative health outcomes.
FINDINGS : For-profit / nonchain ownership and Medicaid occupancy were negatively associated with NA benefits.
Findings for race and age and race and education interactions indicated that the effects of education and age on typology membership varied by race.
Findings for the somatosensory system ( mechanoreception , warming and cooling thermoreception and pain ) are less conclusive.
FINDINGS : Friction of the digit pads was significantly lower in older adults.
Findings from a nationwide survey provide support for the key relationships described above.
Findings from a recently completed 18-month trial of patients with mild Alzheimer's disease will be reported soon.
Findings from comprehensive QOL assessments will guide nurses in providing relevant interventions and evaluating their outcomes.
FINDINGS : From @date@ to @date@ , a total of @number@ unique veterans received health care services through the Elko Clinic.
Findings from focus group and key informant interviews highlight features of LGBTQ senior center experiences that can significantly improve members ' quality of life.
Findings from four of the five studies showed non-significant changes in overall dementia occurrence.
Findings from functional magnetic resonance imaging ( fMRI ) studies that lend further support for the observed age differences in performance monitoring are also reviewed.
Findings from multilevel random-intercept regression models provide support for intergenerational continuity when substance use occurs in emerging adulthood but not when limited to adolescence.
Findings from original research articles using proteomics technologies for the discovery of biomarkers for cardiovascular disease in human are summarized in this review.
Findings from previous studies are generally inconsistent.
Findings from previous studies might have been biased because of either employer self-selection or social desirability , yielding non-representative or artificially positive conclusions.
Findings from primary studies were synthesized using techniques of taxonomic analysis , constant comparison , and importing concepts.
Findings from the current investigation are discussed in relation to studies examining consolidation of nonspeech motor learning.
Findings from the current study may be used to inform the development of user-centered lifestyle interventions.
Findings from the study may be used to plan the provision of accessible end-of-life hospital and home-based services.
Findings from this review identify a wide range of spatiotemporal and dynamic characteristics ; however , their suitability differs according to the aim of measurement.
Findings from this study highlight patterns of decline often associated with abnormal aging.
Findings from this study indicate that older adults have multiple pain-associated conditions that likely reflect multiple physiological mechanisms for pain.
Findings have implications for conceptualizing age-related emotion regulation across relationships and cultures.
Findings have implications for geriatric mental health competencies of students in the health professions.
Findings have implications for improving long-term care and supportive service systems to meet the current and future needs of community-dwelling older adults.
Findings have implications for other interagency partnerships formed to deliver services to vulnerable Veterans.
Findings have implications for prevention research and for the conceptualization of the etiology of AD.
Findings have implications for quality and length of life among older adults with chronic health conditions.
Findings have implications for social workers involved in local service coordination , training , and policy.
Findings have potential implications for the promotion of successful aging.
Findings highlight potentially modifiable contributors to inflammation.
Findings highlight the growing need and demand for hospice within the VHA to provide end-of-life services.
Findings highlight the importance of considering attachment style when assessing how people cope with the daily challenges of arthritis.
Findings highlight the importance of considering older persons households when assessing material well-being and chances of living in poverty in poor regions of the world.
Findings highlight the importance of health and body functionality in influencing the cognitive , emotional , and behavioral management of the aging body.
Findings highlight the important consideration of the caregivers ' characteristics to better determine the quality of their daily experiences in midlife and late adulthood.
Findings highlight the need for better understanding of variation in treatment and symptom burden between younger and older adults with cancer.
Findings highlight the need to target physical activity interventions to specific age cohorts and particular biopsychosocial symptomologies.
Findings in adults indicated that BC-TEOAEs can be measured with properties similar to AC-TEOAEs.
Findings include the Centers for Disease Control Healthy Aging Research Network Audit Tool assessment for environmental walkability factors.
FINDINGS : Indexing of articles was inconsistent , with no term for \ "multimorbidity , \ " and rare use of \ "comorbidity \ ".
Findings indicate a positive relationship between pain severity and AL.
Findings indicated telomere shortening over time for both Cases and Controls.
Findings indicated that annual direct service worker turnover did not significantly vary by provider type ( mean = @percent@ ) .
Findings indicated that the prevalence of self-reported depression and the feeling of reduced interest in most things were respectively @percent@ and @percent@.
Findings indicated that the women held misconceptions and limited knowledge regarding health and aging.
Findings indicate indirect effects of religious attendance on mattering through divine control beliefs and the frequency of social contact.
Findings indicate that both groups had similar issues albeit that they were looking at different phases of the disaster cycle and from different cultural perspectives.
Findings indicate that estimated quality of education is a better predictor of memory performance than ethnicity and years of total education.
Findings indicate that respondents were least satisfied with the environmental and physical domains of QoL.
Findings indicate that satisfaction with aging and constraints were associated with a reduced likelihood of participating in breast cancer screening.
FINDINGS : In @number@ adolescents , BMI and serum UA had relationships with several cardiometabolic measures.
FINDINGS : In @number@ approximately @number@ million people aged ≥ @number@ years were living with HIV in sub-Saharan Africa.
Findings : In @number@ there were @number@ million cancer cases worldwide and @number@ million deaths.
Findings in the last decade have placed the mTOR pathway in a new context as an important , conserved mediator of the aging process.
Findings It was concluded that their implementation in modern general practice was unsuitable and an alternative solution should be sort.
Findings may be interpreted as first evidence for a rather resilient PTSD group of older adults that is available for assessment @number@ years after displacement.
Findings may inform the design of more targeted interventions for alcohol problems in different populations.
FINDINGS : Men were more likely than women to be smokers.
FINDINGS : @number@ @number@ men and women were followed up for a mean of @number@ years ( SD @number@ ) .
FINDINGS : @number@ of the submissions were from consumers of maternity services ( @percent@ ) .
FINDINGS : @number@ records were analysed.
Findings of restored rhythmicity following cancer treatment may have relevance for cancer control and symptom management.
FINDINGS : Of the adults in our sample , @percent@ were non-daily smokers at baseline.
Findings of the baseline and follow-up studies were compared with each other.
FINDINGS : Of the @number@ participants , @number@ ( @percent@ ) had experienced nocturia ( at least two voids per night ) .
Findings of these trials included the following major points.
Findings of the two studies offer initial validity evidence for a sport-specific tool to measure psychobiosocial states.
Findings of this study contribute to our understanding of the underlying mechanism of age variations in emotional experiences.
Findings of this study may have implications for the development of Drp1 based therapeutics for patients with AD and other tauopathies.
FINDINGS : Older people exerted lower peak forces ( anteroposterior and vertical ) than young adults , but not necessarily lower peak power.
Findings on cognitive trajectories and domains affected contribute to better understanding of the clinical nature of cognitive impairment after delirium.
Findings on the relative contribution of purely prospective memory and retrospective memory processes within prospective memory to this trajectory are scarce and inconclusive.
Findings on the testosterone response in women are equivocal with both increases and no changes observed in response to a bout of heavy resistance exercise.
FINDINGS : Our findings revealed that our chosen approach was well accepted by the stakeholders.
FINDINGS : Overall , MHV participants were younger and included more men than SN participants.
FINDINGS : Participants described assessing client and family needs and capacity.
FINDINGS : @percent@ of children had EED.
Findings point to a system of coupled changes in memory and health in late life that is related to underlying beliefs about control over lifestyle.
Findings portray sexuality as an important aspect of old age , with sexual intercourse being construed as having physical and spiritual consequences.
FINDINGS : Positive , statistically significant associations were found between the education level of administrators and all five quality indicators.
Findings provide a potential solution for improving the category learning abilities of older adults.
Findings provide evidence that cumulative experienced stress adversely affects cognitive aging.
Findings provide implications for developing computer training and education programs for the target population.
Findings provide insight into , and factors that facilitate older adults ' physical activity.
Findings regarding a short QT interval were inconsistent across cohorts.
Findings reinforce the importance of landmarks and legible , systematic , and consistently available signage , as well as trustworthy person-to-person information sources.
Findings reinforce the need to incorporate nutrition into cancer care to improve diet quality and to reduce morbidities.
Findings remained significant after controlling for sociodemographics , health , and cognitive functioning.
FINDINGS : Results reported here are from @number@ participants in each group due to missing force place data.
Findings revealed how disability is shaped for older adults with ARVL when they encounter environmental features that are embedded within an ageist and disablist society.
Findings revealed past and current trauma and stress , consequences and / or correlates , and internal and external coping resources among aging offenders.
Findings revealed PFD during childhood to be significantly associated with CRP ( OR = @number@ @percent@ CI [ @number@ @number@ ] ) .
Findings revealed statistically significant improvement in numerous aspects of providers ' knowledge , attitudes , and behavioral intentions subsequent to the training sessions.
Findings revealed striking and asymmetric age-related differences.
Findings revealed that clock drawing was significantly correlated with the driving score on the road test for each of the scoring systems.
Findings revealed that older adults adapted less and more slowly to split-belt walking and showed fewer aftereffects than young adults.
Findings revealed that older adults showed lower performance levels than younger adults but similar learning capability.
Findings reveal greater use of health information technology among older sexual minority adults when compared to their heterosexual counterparts.
Findings reveal many common characteristics for both groups of research participants.
Findings reveal that accumulated childhood misfortune and child maltreatment increased AMI risk , net of several adult covariates , including family history of AMI.
Findings reveal that cumulative experiences over earlier developmental years resulted in resolutions to appreciate their ethnic identity at midlife.
Findings serve to enhance both functional performance assessment and floor rise interventions.
FINDINGS : Seventeen measures met the inclusion criteria.
Findings should be confirmed in a larger population.
Findings should be verified in culturally diverse populations in different ages and settings using biobehavioral approaches.
Findings show consistent evidence only for the individual response , which was in turn associated with well-being.
Findings showed a significant interaction effect of retirement transition and age on daily stressors.
Findings showed poor destination recall in older participants.
Findings showed that CDSMP is an effective program at improving self-efficacy , increasing physical activity , and decreasing limitations.
Findings showed that environmental influences account for the association between parental criticism and adolescent somatic symptoms.
Findings showed that physical exercise programme is so beneficial for increasing older adults ' happiness.
Findings showed that the publication and establishment of the NB resulted in changes in the operating procedures of AARP , ACSM , and AoA.
Findings showed that use of hospice and discussions about particular life-sustaining treatments each had significant associations with having less aggressive medical orders in place.
Findings show that during @number@ years there were @number@ deaths.
Findings show that German policy-makers stress the contribution of volunteering to older people's well-being and have introduced policies for older volunteers.
Findings show that men had lower mortality risk with increasing BMI and that cardiovascular disease was associated with high mortality in the low-BMI category.
Findings show that smoker-nondrinkers are the most disadvantaged group in terms of sociodemographic and health characteristics , while drinker-nonsmokers are the most advantaged group.
FINDINGS : SRH worsened with increasing age in all cohorts.
Findings suggest a link between reminiscence functions and psychological well-being , and indirectly between reminiscence and well-being @number@ months thereafter.
Findings suggest an age-dependent role of gene-environment interactions on ADHD symptoms across adolescence.
Findings suggest a need for intervention to increase understanding within families.
Findings suggest an opportunity to improve access to primary health care , particularly for older women.
Findings suggest a potential moderational role of ghrelin in pathological cognitive decline.
Findings suggest differential effects of personal network characteristics on survival , with only small gender differences.
Findings suggested that elderly people without concurrent cognitive stimulation could benefit from a memory-training program in the form of improved initiation and memory functioning.
Findings suggested that the loss of bodily autonomy is gendered in the sense that men and women experience it in dissimilar ways.
Findings suggested that Western diagnostic categories of mental illness were alien to participants.
Findings suggested various trajectories for MetS components.
Findings suggest increased access to treatment and some improvement in certain areas of care.
Findings suggest MetS , and in particular blood pressure , may represent markers of vascular or neurodegenerative damage in aging populations.
Findings suggest retirement planning education may be particularly important for workers without defined pensions , especially in times of economic volatility.
Findings suggest significant decrease in Z-scores of BMI and an improvement in the ability to perform sport activities ( P < 0·05 ) .
Findings suggest social work educators utilize a combination of classroom-based and experiential learning to maximize student development.
Findings suggest that age differences in emotional experiences vary based on whether questions ask about short versus longer time periods.
Findings suggest that among community-dwelling Mexican American older adults , loneliness has multiple determinants.
Findings suggest that a multi-system score , like allostatic load , may assist in the early identification of adults at increased risk for cognitive impairment.
Findings suggest that APNs generally have positive attitudes , perceptions , and knowledge of UI in women.
Findings suggest that APOEε4 is associated with a reduction in the ability of the brain to dynamically modulate in response to cognitive challenge.
Findings suggest that a somewhat different pattern of everyday functional difficulties can be seen across dementia types.
Findings suggest that a well-designed , one-time continuing education intervention can enhance health professional confidence and clinical practice concerning driver fitness evaluation and mobility planning.
Findings suggest that being female or younger is associated with a higher likelihood of using CAM.
Findings suggest that certain aspects of this measure and previously established cutoff scores may not be well-suited for some populations.
Findings suggest that emotional valence may have an influence on mnemonic processes at encoding rather than modifying cue detection in aging.
Findings suggest that experiences of HIV stigma were intensified for older Black women due to multiple stigmatized social positions.
Findings suggest that further study of anemia as a risk factor for dementia and a target for intervention for cognitive health is warranted.
Findings suggest that gender plays an important role in the relationship between caregiving and labour force participation.
Findings suggest that improving falls efficacy in older African American adults may be beneficial to their mobility and overall health and well-being.
Findings suggest that late-life satisfaction is linked with how emotion-processing regions are engaged and connected during processing of valenced information.
Findings suggest that life review prior to PTSD group therapy has clinical benefits for reducing symptoms of depression and increasing self-assessed wisdom.
Findings suggest that marital and parental status intersections are not uniformly positive , neutral , or negative regarding implications for extra-household social support.
Findings suggest that novel dual modality spatial testing may lead to adoption of postural strategies that deviate from posture first , particularly in older people.
Findings suggest that optimization of body composition and muscle strength is more likely to modify risk of SUI than of UUI in older women.
Findings suggest that performance indicators can be objectively collected and integrated into evaluation designs of community-based , activity-rich lifestyle programs.
Findings suggest that personal views about aging among immigrant elderly populations can be enhanced by promoting physical health , social connectedness , and acculturation.
Findings suggest that racial / ethnic disparities are partially explained by socioeconomic status.
Findings suggest that self-referencing provides an age-equivalent boost in general memory and specific memory for specific source details.
Findings suggest that some tailoring of physical activity promotion strategies targeting the environment may be required for urban and rural midolder aged adults.
Findings suggest that specificity of chronic conditions will be important in developing strategies for disability reduction.
Findings suggest that the aging pyramid shrinks and narrows at the age of @number@ or even before in the present study.
Findings suggest that transitional living programs services were appreciated for the relationships and safety net they fostered.
Findings suggest the importance for outcomes research on NORC programs and related models to consider subgroup differences by involvement.
Findings suggest the importance of considering \ "old age \ " attributions in the context of cardiovascular health events.
Findings suggest the importance of social workers helping older AL residents recognize social support as a means of promoting their positive self-regard.
Findings suggest the potential importance of preventing , detecting , and lowering depressive symptoms to prevent hypertension among women and older adults.
Findings support an advance care planning model with conversations occurring at key points across a person's lifespan.
Findings support a relationship between serous neoplasia and increased secretory to ciliated cell ratios.
Findings support Cloninger's theory about differences between men and women , but not regarding the intercorrelations between temperament dimensions.
Findings support the need for interventions that address the needs of caregivers who have not typically been defined as high risk.
Findings support the notion that observations of SLP appear to significantly influence students ' career choices.
Findings support the utility of our novel method for staging preclinical AD.
FINDINGS : The airway mechanical characteristics decreased with aging , specifically a @percent@ pressure drop was observed for the 80-year-old as compared to the 50-year-old.
FINDINGS : The assistance eases daily life with regard to practical matters and increases adherence to a medicine regimen.
FINDINGS : The core meaning was a deeper sense of vulnerability as you grow old.
FINDINGS : The discovery phase consisted of @number@ case and @number@ @number@ control samples , with genotyped and imputed data at @number@ @number@ @number@ SNPs.
Findings : The initial literature search yielded @number@ total references.
FINDINGS : The @number@ participants identified issues with inaccessible equipment , including mammography machines , examining tables , and weight scales.
FINDINGS : The qualitative data revealed challenges in balancing professional obligations and personal concerns.
FINDINGS : There are well documented differences in preferences for end-of-life care and utilization of services between non-Hispanic Whites and African Americans.
FINDINGS : There were many similarities between the seven organisations with regard to the proposed practice improvements.
FINDINGS : There were significant differences in the joint displacement and muscular activity among the different phases.
FINDINGS : Thirteen participants satisfactorily completed the protocol.
FINDINGS : Thirty-eight studies ( @number@ participants ; @number@ cases of hepatotoxicity ) met the selection criteria.
FINDINGS : This concept was discussed in three ways : as an intervention , in reference to everyday behaviors , and as an outcome.
Findings : Three broad categories of technology are leading non-energy-based rejuvenation technology : lasers , light therapy , and non-laser-based thermal tightening devices.
FINDINGS : TLE at age @number@ years was approximately @number@ years longer for women than men.
FINDINGS : Twenty one publications covering @number@ studies were included.
Findings uncover that using specific pain order sets seems to improve the detection of pain , which should be a routine part of nursing assessment.
Findings underscore that there are positive aspects of spousal caregiving for older wives that offset the innately unpleasant nature of household tasks.
Findings underscore the developmental nature of the moral identity construct and suggest that moral motivation becomes more self-integrated with age.
Findings underscore the distinct neural processing of the auditory spatial cues in sound localization and their selective deterioration with advancing age.
Findings underscore the emotional and practical challenges that older people may encounter vis-à-vis policy discourses that encourage family responsibility for care.
Findings underscore the importance of socio-ecological influences on disability.
Findings underscore the need for attention to the physical health of those with MHD including support in smoking cessation.
Findings underscore the significance of the decline in ovarian estradiol production in midlife and its role in shaping memory function.
Findings warrant replication from a long-term , adequately powered , RCT.
FINDINGS : We analysed @number@ @number@ cases.
FINDINGS : We enrolled @number@ elderly subjects in the PST group and @number@ elderly subjects in the social contact comparison group.
FINDINGS : We identified five themes and generated a hypothetical framework for in-depth understanding of vaccination behaviour among older people.
FINDINGS : We identified @number@ cases of incident lung cancer in @number@ @number@ participants with HIV.
FINDINGS : We obtained samples from @number@ patients with ALS and @number@ control individuals.
Findings were analyzed in the light of our previous available data on levodopa-treated PD patients.
Findings were broadly consistent across subgroups.
Findings were compared by sex.
Findings were compared with previous research in the Netherlands.
Findings were confirmed in Hypertension Insulin-Resistance Study premenopausal women.
Findings were consistent in sex and race subgroups and for heart failure with preserved or reduced ejection fraction.
Findings were consistent in subsets according to ADL status , grip strength , and comorbidity.
Findings were generally similar for satisfaction , but not positive affect.
Findings were integrated and presented in a convergence code matrix.
Findings were maintained after adjusting for baseline health status and depression.
Findings were mixed on death of a loved one , which was related to abstinence in some and relapse in others.
Findings were not explained by health and demographic covariates.
Findings were replicated in an independent sample of @number@ SORL1 variants detected in @number@ AD cases and controls.
Findings were replicated in the Women's Genome Health Study ( n = 22 @number@ ) .
Findings were reviewed , thoroughly examined and , finally , summarized herein.
Findings were similar among HIV-seropositive participants.
Findings were similar for both the anterior and posterior.
Findings were similar for elderly living in institutions and in the community.
Findings were similar for trajectories of isolated systolic BP trajectories but were attenuated for diastolic BP trajectories.
Findings were statistically significant ( p < @number@ ) for the years @number@ @number@ and @number@
Findings were synthesized and key factors identified.
Findings will be disseminated through scientific articles / presentations and public events.
FINDINGS : Women coped with functional decline , such as difficulty getting up from the floor , in many different ways.
Finding that a participant did not have a MUAC < 25th percentile on physical examination had a @percent@ negative predictive value for presarcopenia.
Finding ways to curtail costs is urgently needed.
Fine motor control was assessed using @number@ subtests of the Purdue Pegboard ( unimanual , bimanual , sequencing ) .
Fine PM ( PM2.5 ) , black carbon , organic carbon , and sulfates were measured at a stationary ambient monitoring site.
Finger cold tests supported more superior local cold tolerance for older haenyeos than for older non-diving females.
Finger force vectors were measured using six-component force / torque sensors.
Finger thickness , especially in nondominant hands , should be taken into account while evaluating FDT scores because of its negative effect on dexterity.
Fingertips wrinkle due to long exposure to water.
Finite-element analysis ( FEA ) of quantitative computed tomography ( QCT ) scans can estimate site-specific whole-bone strength.
Finite element analysis revealed that due to its higher elastic modulus , old apical dentine has a higher stress level than young dentine.
Firearm use was a statistically significant risk factor for all outcome measures.
Firm conclusions about whether mid-life or long-term statin use has an impact on cognitive decline and dementia remain elusive.
First , a clear description was made on the identification , quantification , and scoring of PLMS and their associated events.
First , active aging was defined as high reported health , life satisfaction and self-perception of aging.
First , age at onset , disease duration , and glycemic dysregulation were delineated for their association with cognitive changes.
First , a general increase of NA across a larger period preceding death potentially mirrors basic processes of degradation of the human system.
First , a general needs assessment was conducted by reviewing the literature and medical societies ' publications and by consulting experts.
First , all the sound primes were presented.
First and foremost , the world is rapidly getting old.
First- and second-order Confirmatory Factor Analysis ( CFA ) were conducted to identify the most adequate model.
First , an improvement of the assemblies ' properties and stability in biological conditions has to be addressed.
First , APOE ε4 + carriers had poorer EF performance and steeper 9-year decline.
First , a Swedish 10-year birth cohort ( N = 1 @number@ @number@ ) was established.
First , bilingual older adults experience changes in word-level processing that are language-non-specific , potentially because lexical accessibility decreases with age.
First , by classifying aging-related genes as pro- or anti-longevity , we define distinct pathways and genes that modulate aging in different ways.
First , by using specific dyes , we found deposits of polymers of GlcNAc in sporadic but not in familial AD.
First-choice treatment for invasive carcinomas is complete surgical excision.
First , cluster analyses examined potential Meaning in Life-profiles.
First described by Hayflick and Moorhead in @number@ it has since become a popular model to study cellular aging.
First , descriptive analyses of alternative retirement options , based on Social Security retirement benefit rules , are provided.
First fixation durations showed an interaction between age and literacy skill , decreasing with age among more skilled readers but increasing among less skilled readers.
First , FK-A11 is an ATP competitive PI3K inhibitor.
First follow up is being prepared for @date@ .
First generation antipsychotics were associated with elevated enzyme activity in both groups.
First , genes progressively gain new splice variants with time.
First group aims at answering the question \ "why do we age ? \ " and determining a biological purpose of this process.
First , how do astrocytes respond to and alter the biomechanical environment of the ONH and the physiologic stresses created therein ?
First , how do interactions among morphology and tissue quality traits relate to functional adaptation ?
First , how many times did the expansion occur throughout human history ?
First , increasing evidence from both experimental and clinical studies supports the concept that \ "a man is as old as his arteries \ ".
First , interaction terms were used to test differences in rate of decline across subgroups.
First intervention at time of diagnosis of AD is too late , when by definition , final conversion to AD has already occurred.
First , I provide an overview of the advances in understanding of the structures and functions of human telomeres.
First , is it likely that gene-environment interactions actually exist ?
First , I sketch the rationale , logic , expectation and evidence that long-term couples might develop and display unique advantages in everyday competence.
First , is there a buildup of undigested waste that can be removed by stimulation of autophagy ?
First , it examines barriers to healthy aging , including health behaviors and access to health screenings and services.
First , it is not immediately clear from the definition what particular element ( s ) of the work situation constitute ( s ) SE.
First , its incorporation into chromatin is replication independent unlike the replication-coupled deposition of its canonical counterparts H3. @date@ .
First-line treatment for TDS should be testosterone replacement therapy ( TRT ) , which is reported to improve several TDS symptoms.
First , low-executive OAs showed greater success-related activity in the PFC , whereas low-memory OAs showed greater success-related activity in the MTLs.
Firstly , a maximum variation sample of @number@ students completed a worksheet , giving brief written answers on questions regarding their geriatric medicine clerkships.
Firstly , apigenin exhibited a potent antioxidant activity in vitro.
Firstly , HS-1793 inhibited phosphorylation of PI3K and Akt in PC-3 cells.
Firstly , set the search range of the deviation as the deviation candidates according to the prior knowledge.
Firstly , there are conceptual ambiguities in distinguishing trust from related concepts , such as confidence or dependence.
Firstly , we compared these HILIC columns for the non-targeted metabolic assay using pooled plasma.
Firstly , we conducted qualitative interviews with @number@ elderly respondents , generating @number@ main subjective components of successful aging.
Firstly , we showed that PPARγ specifically bound to 15d-PGJ₂-immobilized beads.
Firstly , we show that the method clearly discriminates between segments of electrocardiogram records characterized by normal sinus rhythm , ventricular tachycardia and ventricular fibrillation.
First , many older adults with HIV in our study expressed a variety of cognitive complaints that interfered with daily function.
First mechanistic insights into the dysregulation of DNA methylation by recurrent mutations have already been gained.
First , molecular interaction of disease protein network generates @number@ proteins with @number@ interactions , which determines the common genes / proteins between diseases.
First morning void urine samples were collected to measure melatonin's major urinary metabolite , 6-sulfatoxymelatonin ( aMT6s ) .
First , most mental disorders are heterogeneous in their clinical feature or intrinsic pathological mechanisms.
First , none of the U.S.-based studies examine the association at the national level.
First observations of morphology and morphometry of actinic keratoses are reported.
First of all , the participants were tested for their tactile sensitivity and perception.
First of all , we established gemcitabine-resistant T24 cells ( T24GR ) from T24 bladder cancer cells and performed gene expression profiling.
First of these challenges must take into account demography changes.
First one-on-one interviews of the residents were conducted by two researchers from our group.
First-onset TMD developed in @percent@ of participants per annum , typically producing mild to moderate levels of pain and disability in cases.
First-order partial correlations between regional body fat and cognitive executive function were computed partialling out the effects of whole body fat.
First , participants were asked to recall knowledge from different life periods.
First , populations with delayed effects could experience unchanging or increasing adult mortality even when background mortality has been declining for long periods of time.
First reported in animal models , it remains uncertain if peripheral inflammatory and / or infectious conditions in humans can promote Aβ brain accumulation.
First research shows that the different approaches are applicable to study populations with intellectual disabilities as well.
First , response amplitude during difficult , endogenous relative to exogenous decisions increased with age.
First , responses to incongruent trials were faster following incongruent trials than following congruent trials , but only for adults and adolescents.
First , restricted by the diameter of the drainage tube , the PCCLC should be used only for small gallstones in high-risk surgical patients.
First , SE is seen as a multidimensional construct.
First , senescent MSCs are so heterogeneous that not all of them express the same phenotypic markers.
First , sleep-wake disorders ( SWDs ) are very common and may be the first / main manifestation of underlying neurological and psychiatric disorders.
First , some widowers do sanctify their late wives.
First step in prevention is to identify patients at risk of functional decline.
First , that the evolution of increased human longevity was driven by increased late-life reproduction by men in polygynous primordial societies.
First , the association between social activity and all @number@ domains of cognitive function was significantly mediated by cognitive activity at the within-person level.
First , the authors summarize some recent insights into the function of STAT3.
First , the cause of pain is often a condition that is typically not reversible.
First , the dimension of the quality scores is reduced to two principal components.
First , the effect of age on quality of life was studied with a meta-analysis.
First , the effects of the number of MS components on CAVI are stronger in females than in males.
First , the frequency of involuntary and voluntary memories and future thoughts are similarly related to general measures of emotional distress.
First , the imposition of a licence restriction was usually associated with a reduction in absolute crash rates.
First , the influence of age on ANP and BNP levels was examined.
First , the labrum should be preserved or reconstructed when possible.
First , the neural substrates of connectivity and techniques used in the study of connectivity are described with a focus on neuroimaging methodologies.
First , the physiological roles of NTFs in aging dopaminergic neurons must be comprehensively understood.
First , the prediction accuracy of MTA is comprehensively validated using data sets of known perturbations.
First , the prior information of LGN was used to create a prior mask.
First , there is virtually no winter in Okinawa.
First , the relative prevalence of mutations in sperm correlates weakly with their in vitro activating properties and occurrence in cancers.
First , there were no consistent , statistically significant differences between the pilot and control groups in crash risk in the two years following screening.
First , the scope of the study was expanded by collecting data from coresident spouses or romantic partners.
First , the T2D group performed more slowly than the controls.
First , the term FACE-LIFT has never been adequately defined.
First , the total cellular cholesterol content increase was 2-3-fold and 3-5-fold in TT1 and TT2 cells , respectively.
First , the variability might have resulted from irregular fine movement motor control in older adults.
First , the very nature of hormesis using toxins as a treatment regimen harbors the inherent danger of detrimental consequences.
First , they had a formal cognitive evaluation by The Mayo Clinic Study of Aging.
First , they require the knowledge of the social and cultural context in which they occur.
First time p53 was found in the complex with viral large T-antigene in the cells transformed by small DNA virus SV40.
First-time users ( FTUs ) showed similar gait parameter improvement patterns as frequent WW users ( FUs ) .
First , to test for a causal link between polyamines and α-synuclein toxicity , we investigated a yeast model expressing α-synuclein.
First , two experiments were devised to further investigate secondary distinctiveness-based effects in relation to aging.
First , two independent dermatologists assessed cosmetic results using a 5-point wrinkle assessment scale.
First type of glomeruli was predominant in younger cases , while second type of glomeruli was predominant in cases older than @number@ years.
First , using an unprecedentedly large @number@ , 430-person sample , we modeled age-related differences with substantially greater precision than have prior efforts.
First , we aimed to establish whether human non-synaesthetes systematically map tactile and visual dimensions - a combination that has rarely been studied.
First , we chose the age-related miRNAs by polynomial regression models.
First we compared the InM volume and number of Gal-Ir neurons of @number@ males and @number@ females in the course of aging.
First , we confirmed the uptake time course in ASC-depleted gulo ( - / - ) mice , which cannot synthesize ASC.
First , we crossed ataxin-2 knockout mice with TDP-43 ( also known as TARDBP ) transgenic mice.
First , we describe a signalling network signature that overrides bioenergetics stress- and oncogene-induced senescence ( OIS ) phenomena in CSCs residing at pre-invasive lesions.
First , we describe canonical changes in human sleep quantity and quality in cognitively normal older adults.
First we establish the socio-economic categories for which members are most financially vulnerable.
First , we estimate a set of options related to the duration of marriage required to receive divorced spouse and survivor benefits.
First we evaluated @number@ SNPs in a case-control study combining nine genome wide association studies ( GWAS ) .
First , we evaluate whether criterion placement in episodic memory differs for older and younger adults.
First , we examine aging in Sweden along demography , economy , and housing.
First , we examined parametric increases and decreases in activation to increasing WM load ( positive modulation effect and negative modulation effect ) .
First , we examined the role that the type of expansion ( systematic vs. nonsystematic ) has in producing a benefit of expanded retrieval.
First , we examine the relationship between major depression and nonsuicide mortality among U.S. adults aged @number@ and older.
First , we find evidence supporting older adults ' capacity to upregulate dopamine synthesis.
First , we find that the L1 ORF2 protein tolerates the addition of protein domains both at the amino- and carboxy-terminus.
First , we focused on mechanical stress and developed a loading device for applying consecutive mechanical flexion-extension stress to the mouse LF.
First , we found an age effect with better face matching performance in younger than in older adults.
First , we identified all visible small ( ⩽ @number@ mm ) intracortical and juxtacortical lesions on postmortem MRI.
First we introduce the concept of flow in bone and the three calibers of porosity through which fluid flows.
First , we investigate whether the near-elderly who face higher health risks save more.
First , we leveraged the social and physical infrastructure of an existing program to recruit participants through community sites where older adults gather.
First , we performed a combined analysis of pooled individual patient data.
First , we performed single marker linear regression analysis relating the individual single nucleotide polymorphisms ( SNPs ) with plasma Aβ40 and Aβ42 levels.
First , we rendered a segmentation algorithm that uses outlier detection based on model checking techniques within a Bayesian mixture model.
First , we review emerging evidence that changes in peroxisome activity can be linked to the epigenetic regulation of cell function.
First , we review how sex / gender moderates autism-related brain changes and how this informs general models of autism etiology.
First , we screened previously reported mutational hotspots ( exons 2-6 , @number@ @number@ @number@ @number@ and @number@ ) .
First , we should suspect the disease processes commonly associated with aging.
First , we showed that homozygous loss of MCT4 dramatically sensitized cells to the MCT1 inhibitor AZD3965.
First , we use a broad perspective for the definition of health behaviors to capture all relevant aspects of health-behavior change in older adults.
First , we will describe the role of FGF21 in interorgan energy metabolism and explain how its functions as a stress hormone can improve healthspan.
First , we will discuss the regulation of caspase activation and activity.
First , we will give an overview of age-associated epigenetic signatures , focusing on DNA methylation.
First , we will provide a brief background of PDE4 , and the rationale for its extensive study in cognition.
First , what is the relative strength of socioeconomic versus behavioral risk factors in explaining race differences in CRP levels ?
First , when time constraints ( CL ) were matched for the two groups , no aging effect was observed.
First , with age , caudate head connectivity increased with a large region of ventromedial prefrontal / medial orbitofrontal cortex.
First , young children exhibited less movement-related activity in task-relevant motor areas compared with adults ( movement-related cortical potentials ) .
FIS and VIS triggered similar lower thoracoabdominal synchrony in the elderly subjects , whereas in the healthy adults FIS induced lower synchrony than did VIS.
FI scores ≥ @number@ were also associated with higher risk of delirium ( adjusted OR , @number@ @percent@ CI , @number@.39-9.92 ) .
Fisetin is a small , orally active molecule which can act on many of the target pathways implicated in AD.
Fish consumption may decrease CRC risk by @percent@ whereas garlic intake is not significantly associated with reduced CRC risk.
Fish consumption was negatively associated with dementia and cognitive performance positively associated with non-refined cereal consumption.
Fish decreased the risk of poor nutrition.
Fisher exact test was performed in our two combined study samples.
Fisher's exact test and two-sample t-test were used to compare Most Stressful Events between caregivers.
Fisher's exact tests were used to compare , by frailty status , percentages of those with morbidity.
Fish Hg MIF anomalies are 10-fold lower than those published for fish species from midlatitude lakes.
Fish-oil consumption was assessed by using validated questionnaires as never ( referent ) , less than daily , or daily.
Fish oil / omega-3 fatty acid consumption was associated with lower AA / DHA ratios even among ε4 carriers.
Fish oil patients had shorter duration episodes of AT / AF with no difference in frequency compared to controls.
Fish oils and vitamin D supplementation may generally be recommended , while thunder god vine should be avoided.
FIS required more muscle activity in the elderly subjects to create an increase in chest wall volume.
Fission protein @number@ was instead up-regulated in CC patients relative to the other groups.
FIs were calculated across six waves and the distribution at each wave was evaluated.
Fitness improvement correlated with changes in hippocampal perfusion and hippocampal head volume.
Fitness interventions may enhance cognitive functioning.
Fitness was assessed and exercise prescribed according to the Step Test and Exercise Prescription protocol.
Fit of latent structural models varied between good and poor.
Fitted time-intensity curves ( fTICs ) were generated and evaluated for curve pattern.
Fitting motifs in a minimalistic protein-protein network allowed to probe for connectivity to distinct stress sensors.
Fitting the parameters of this model is a challenging problem which we approach using an alternating least squares optimization algorithm.
Fitzpatrick skin type and Glogau's photoaging type were assessed.
Five AD biomarkers are sufficiently validated to have been incorporated into clinical diagnostic criteria and commonly used in therapeutic trials.
Five affected and @number@ unaffected participants from a 3-generation family with pure adult-onset autosomal dominant HSP of unknown genetic origin were included.
Five anatomical liver measurements were determined using CT scans of @number@ normal livers.
Five- and 10-year age-standardized net survival increased throughout the whole period across age groups and reached @percent@ and @percent@ , respectively.
Five articles reported information on functional limitation and one on disability.
Five cat personality axes were identified by Principal Component Analysis ( PCA ) based on observer-rated items and on coded behaviours.
Five children had a considerable reduction of FEV ( @number@ ) .
Five connectivity networks are constructed , one from each frequency sub-band.
Five defining attributes were identified : multidimensional process , personal development , active individuals , symptom response , and symptom control.
Five different drinking patterns were determined using data over two consecutive survey periods.
Five distinct developmental trajectory groups for nutritional risk score were identified.
Five experts and @number@ subjects participated in the experiment.
Five genes associated with resilience were included in the model.
Five heterogeneous trajectories were identified : stable high , stable moderate , stable low , high-to-moderate , and moderate-to-low.
Five hundred and eighteen subjects were included in analysis.
Five hundred and forty-nine ( @percent@ ) had a syncopal event and / or an unexplained fall in past @number@ months.
Five hundred and ninety-four older adults ( mean age @number@ years , SD = 5.8 ) were involved in this cross-sectional study.
Five hundred elderly people were randomly selected for the study.
Five hundred eleven brain MRI scans from elderly nondemented participants of a prospective population-based imaging study were used.
Five hundred ninety-eight participants reported that they were diagnosed with cancer or malignant tumours.
Five hundred participants , averaging @number@ years of age at first measurement , were measured three times over @number@ years.
Five hundred thirty women had delivered one child , @number@ women had delivered @number@ to @number@ children , and @number@ women had delivered ≥4 children.
Five hundred twenty-three patients were included.
Five loci demonstrate clear evidence of several independent association signals , and many loci have significant effects on other metabolic phenotypes.
Five logistic regression models ( for CHA RESULTS : New-onset AF occurred in @number@ patients ( @percent@ ) .
Five main lifespan indicators and the Human Development Index ( HDI ) were calculated.
Five measures were considered in round three.
Five milliliters of venous blood was collected from participants ' cubital vein and blood glutamate , glucose , GOT and GPT levels were determined.
Five million Americans require admission to ICUs annually owing to life-threatening illnesses.
Five months after start of drug administration , his AMS score improved to @number@ but IIEF-5 score showed little change.
Five months after the first treatment administration , she developed extensive purpuric lesions on her lower limbs , abdomen face and neck.
Five OAwD along with their caregivers participated in this study which took place in a simulated-home setting.
Five observational studies showed a significant positive association , whereas three studies did not.
Five of fifty-four samples were processed for tyrosine hydroxylase immunostaining.
Five of @number@ individuals had longitudinal extension , even with correction for skeletal growth.
Five of @number@ probands screened showed APP duplication , a similar prevalence to APP missense mutation.
Five of the factor-derived subscales showed good or excellent internal consistency.
Five of the @number@ interventions that directly targeted balance confidence showed benefits.
Five of the @number@ patients with PU and five of @number@ patients without PU underwent amino acid profiling.
Five of these CpGs at @percent@ FDR could explain @percent@ of BMD variation.
Five of these targets showed differential expression in late onset AD / Intermediate AD pathology brains.
Five of the trials in older patients incorporated a geriatric assessment ( @number@ % ) .
Five of those companies subsequently participated in in-person site visits.
Five out of six included studies were cross-sectional and one was a prospective cohort study.
Five out of the seven studies investigating daily functioning showed an association between comorbidity burden and decreased daily functioning.
Five papers described a single screening question for cognitive impairment with each using a different question.
Five patients died in the first year after operations.
Five patients had a clinical relevant laboratory abnormality.
Five patients had diabetes.
Five patients ( @percent@ ) had minimal benefit with continued pain , swelling , and tenderness over the Achilles and functional deficits.
Five patients received targeted narrowband UVB for depigmentation with good clinical results.
Five patients were classified as type @date@ as type @date@ as type III , and @number@ as type IV.
Five percent of the advertisements featured at least one older character.
Five plants and five animals were graded according to size.
Five positive and negative recommendations were approved via individual member vote.
Five principal component coefficients , extracted from PSD signals , were retained for analysis according to the Mahalanobis distance classifier.
Five professionals ( dietitian , personal trainer , occupational therapist , and two physicians ) had similar responses.
Five progressive stages of aging have been identified and matched with recommended courses of face-lifting , blepharoplasty , volume augmentation , and skin resurfacing techniques.
Five random determinations for each ST and each parameter were performed.
Five samples contained coliforms ; two of those contained E. coli at less than 10 ( @number@ ) cfu / g.
Five samples were fabricated for each group ; therefore , a total of @number@ resin disks for each testing method was prepared.
Five self-rated Instrumental Activities of Daily Living ( IADL ) were dichotomized into no impairment vs any impairment.
Five separate models with varying input variables were estimated for each response variable.
Five sites were treated with @number@ U of onabotulinumtoxinA.
Five smaller scale sensors of natural parameters ( air temperature , moistness , carbon monoxide , carbon dioxide , and glow ) were utilized.
Five species of them have been recorded in Chinese pharmacopoeia with name Hippocampus ( Chinese name Haima [ symbol : see text ] ) .
Five specimen-specific femur models were developed from in vitro experiments under a simulated stance loading condition.
Five stages of acceptance emerged from the data from preinstallation to @number@ years postinstallation.
Five studies analyzed changes in LC according to age.
Five studies delivered an individual music intervention ; in the others , the intervention was delivered to groups of participants.
Five studies examined measures of physical function and performance.
Five studies found significant changes in participant depression symptoms after doing yoga.
Five subjects had serial cognitive testing available , permitting descriptive analysis of change.
Five subjects ( @percent@ ) presented with unusual anatomy.
Five swallows each of @number@ mL liquid ( L ) and viscous ( V ) bolus were analyzed.
Five themes emerged : self-growth , self-determination , structure , balance , and sense of purpose.
Five times more drugs were initiated for a new diagnosis than for correction of under-treatment.
Five-Times-Sit-to-Stand and TUG were strongly correlated with each other , r = @number@ @number@ P < @number@ for VU- and VU + , respectively.
Five to ten per cent of fall accidents of elderly people result in trauma.
Five valid ARFI elastographic measurements were obtained in all \ "normal \ " patients in both kidneys.
Five variants reached nominal significance ( P < 0.05 ) in the pooled GWAS data compared to @number@ expected under the null hypothesis.
Five were associated with other or related pathological conditions.
Five-year cumulative incidence of NRM was @percent@ with ES versus @percent@ without ( P = @number@ ) .
Five-year cumulative incidence of relapse was @percent@ with ES and @percent@ without ( P = @number@ ) .
Five-year delay in the full retirement age decreases federal spending by @percent@ , while 2-year delay in the early entitlement age increases it by @percent@.
Five-year female rates were always higher than males.
Five-year incidence of dementia was negligible except for APOE-e4 / e4 individuals and those over @number@ y.
Five-year-olds ' clear speech words also had more final stop releases and initial sibilants with higher spectral energy than did their casual speech words.
Five-year OS was @percent@ with ES versus @percent@ without ( P = @number@ ) .
Five-year PFS was @percent@ in patients with ES versus @percent@ in those without ( P = @number@ ) .
Five-year PFS was @percent@ ± @percent@ and @percent@ for patients with B-K fused and γH2AX-expressing PLGA versus negative tumors ( P = @number@ ) .
Five-year PFS was @percent@ ± @percent@ and @percent@ ± @percent@ for fusion positive and negative patients , respectively ( P = @number@ ) .
Five-year progression-free and overall survival ( PFS , OS ) was @percent@ and @percent@ , respectively.
Five-year rates for 1975-79 , 1980-84 , 1985-89 , 1990-94 , 1995-99 , @date@ , @date@ were : @number@ @number@ @number@ @number@ @number@ @number@ @number@
Five-year relative survival increased in Germany from 2002-2004 to 2008-2010 for most cancer sites.
Five-year relative survival was calculated by major age group.
Five years later , @number@ participants remained in the community and had no missing data.
Five years later , @number@ participants returned for follow-up assessments.
Five-year survival estimates were @percent@ , @percent@ , and @percent@ , respectively , for patients with Medicaid , no insurance , and other insurance.
FI was verified through the Minimum Data Set ( MDS ) @number@ which was also used to assess toileting programs.
Fixation , central , subfield , and mean retinal thickness were acquired together with macular sensitivity function.
Fixed effect logistic regression models were used to estimate the risk of ER visits following the SSO event.
Fixed-effect model was chosen for homogeneous studies ; otherwise , a random-effect model was used.
Fixed effects models assessed whether social capital and perceived control were related to changes in problem drinking.
Fixed effects regressions were used to estimate the predictors of functional health.
Fixed thresholds were set at @number@ nmol / L for SM and @time@ / ml for MPF.
FK-A11 showed in vivo antitumor activity by both i.v. and i.p. administration in a dose-dependent manner.
Flare-up pain was commonly experienced , and immobility and suffering led older adults to adopt several strategies to live with their pain.
Flavin-containing monooxygenases ( FMOs ) are primarily studied as xenobiotic metabolizing enzymes with a prominent role in drug metabolism.
Flavonoid redox chemistry depends more on the chemical milieu , specifically on pH.
Flavonoids , a group of secondary metabolites widely distributed in the plant kingdom , have been acknowledged for their interesting medicinal properties.
Flavonoids are known for their healthy effects and limited toxicity.
Flavonoids have been demonstrated to provide health benefits in humans.
Flavonoids , including apigenin , were recently shown to reduce the SASP of a human fibroblast strain induced to senesce by bleomycin.
Flavonoids reduce Aβ production , inhibit neuroinflammation , increase cerebrovascular function , and improve cognitive performance.
Flavour intensity was the biggest discriminant between the three age groups and declined with an increase in age.
FLDK restored antioxidant enzyme activities , as well as reduced the lipid peroxidation product , malondialdehyde , and inflammatory mediators.
Fleiss ' kappa was used to assess the level of agreement between the four raters.
F ( - ) levels were a major factor associated with DF.
Flexible bronchoscopy is safe and useful for early diagnosis and effective management.
Flexible nonlinear growth curves indicated a hierarchical pattern of WM development.
Flexible spatial navigation , e.g. the ability to take novel shortcuts , is contingent upon accurate mental representations of environments-cognitive maps.
Flicker-induced dilatation was unchanged within the groups and throughout the study period.
Flies lacking dMRP4 have a shortened lifespan under both oxidative and normal conditions.
Flies were supplemented with cranberry on three dietary conditions : standard , high sugar-low protein , and low sugar-high protein diets.
Flight simulator performance and cognition were tested yearly ; there were an average of @number@ ( ± @number@ range 1-13 ) data points per participant.
Floaters and flashes are most commonly symptoms of age-related degenerative changes in the vitreous body and posterior vitreous detachment.
Floor-sitting is culturally relevant to the Indian context.
FLoSS-based selection yields families with exceptional longevity , satisfactory sibship sizes and numbers of living siblings , and high ages.
Flourishing older adults exhibit a sense of personal growth in that they are still evolving and changing.
Flow cytometric analyses were performed for hematopoietic and immune reconstitution.
Flow cytometric analysis revealed that HS-1793 induced G2 / M arrest in the cell cycle progression in both types of cells.
Flow cytometric analysis revealed that HS-1793 induced G2 / M arrest in the cell cycle progression in HCT116 cells.
Flow cytometric analysis revealed that rutin induced G2 / M arrest in the cell cycle progression and induced cell apoptosis.
Flow cytometry for apoptosis assay was also conducted to determine the fate of the photo-aged fibroblasts.
Flow cytometry revealed no effect of IFN-γ on apoptosis of cell lines and no effect on cell aging as assessed by β-gal staining.
Flow cytometry showed that a @number@.6-fold increased proportion of the wrinkled-skin fibroblasts were in their cell cycle S-phase , indicating increased proliferation.
Flow cytometry was used to assess apoptosis and autophagy levels in the spheroids under nutrient restriction.
Flow-mediated dilation ( FMD ) is a noninvasive technique used to measure conduit artery vascular function.
Flow response among women was significantly larger than in the men.
Flow sensitivity to a mild hypercapnic challenge was also examined.
Flow sorting confirmed reduced germ cell populations at the leptotene / zygotene stages of meiosis in mutant group.
Flows were measured in the major intracranial and extracranial vessels.
Flow through the 360° circumference of TM structures may be non-uniform , divided into high and low flow regions , termed as segmental.
Flow waveforms and their frequency composition , transfer functions from blood to CSF flows and cross-correlations were analyzed.
Fluctuations in the proportion of centenarians are much higher than for nonagenarians , both in relation to towns and to years.
Fluid-attenuated inversion recovery images were acquired using a high-resolution 3-dimensional ( 3-D ) sequence that reduced partial volume effects seen with slice-based techniques.
Fluid intelligence scores were lower and WMH scores were higher in the older samples.
Fluorescein angiograms shows raised number of ischemic retinal capillaries in patients with ARMD ( p = @number@ ) .
Fluorescein staining is highly prevalent in subjects with pterygium.
Fluorescence-activated cell sorting ( FACS ) -purified Tbx18-expressing cells behaved as MSCs in vitro.
Fluorescence-activated cell sorting ( FACS ) strategies to purify distinct cell types from the pool of fetal human myofiber-associated ( hMFA ) cells were developed.
Fluorescence intensity measurement performed using a spectrofluorophotometer , before and after storage in cola , orange juice , red wine , and distilled water.
Fluorescence measurements were carried out by a fluorescence spectrophotometer before and after thermocycling ( @number@ cycles , 5°C and 55°C ) .
Fluorescence microscopy and flow cytometry were performed to detect the internalization of EGFR.
Fluorescent imaging in vivo and ex vivo revealed @number@ iodide-labeled hADSCs in peripheral organs and brain after TBI.
Fluorescent-labeled liposomes were prepared to evaluate cellular uptake and skin permeation efficiency.
Fluorescent light-up probes with aggregation-induced emission ( AIE ) characteristics have been focused on recently.
Fluorine-18-FDG uptake in aortic segments in @number@ subjects ( @number@ men , @number@ women ; ages 5-82 years ) was evaluated in this study.
Fluorodeoxyglucose PET demonstrated hypometabolism in bilateral frontal and temporoparietal cortices.
Fluoroscopy and echocardiography confirmed an adequate position and function without any paravalvular or transvalvular leakage or elevated transvalvular gradients in any case.
Fluparoxan ( 1mg / kg / day ) was administered to TASTPM and wild type mice from @number@ to @number@ months of age.
Fluparoxan treatment prevented age-related spatial working memory deficits in the spontaneous alternation task but not spatial reference memory deficits in the Morris water maze.
Flupirtine-MR is an oral modified-release formulation with a @number@ mg fast-input and a @number@ mg portion with slow protracted release.
FMD returned to baseline levels within @number@ min in young sedentary and endurance-trained subjects but remained depressed in middle-aged sedentary and endurance-trained subjects.
FMDTs were also measured in the presence of an interfering AM to discourage the use of temporal-envelope cues.
FMDTs with and without interfering AM were significantly correlated with each other.
FMD was significantly greater in EX ( @time@ ± @percent@ ) versus CON ( @number@ ± @percent@ ) ( P < @number@ ) .
FMR1 genotypes offer a possible explanation for differences in IVF outcomes between races / ethnicities.
FM was directly calculated as body weight minus FFM.
FN also increased PKG-I in another type of contractile cell , rat vascular smooth muscle cells ( RVSMC ) .
FNBMD was higher in NHANES 2005-2008 than in NHANES III , but between-survey differences varied by age , sex , and race / ethnicity.
FNC , in a correct setting , is a reliable and effective method for the follow-up management of BC patients.
FNIH threshold for aLM ( < @time@ kg ) emerges as a useful tool to capture women with damage of the muscle-bone unit.
F ( @number@ ) -IPs predicted loss of total adiposity over time among women.
F ( @number@ ) -IPs were associated with higher levels of adiponectin , leptin , and tumor necrosis factor-α ( TNF-α ) .
F ( @number@ ) measures and receiver operating characteristic curves were used to identify specific ( ≥98% ) features.
Focal cerebral ischemia was induced in C57BL / 6J mice and endothelial nitric oxide synthase knockout ( eNOS KO ) mice by photothrombotic cortical occlusion.
Focal embolic stroke was performed by middle cerebral artery occlusion with fibrin clot followed by reperfusion with i.v. human recombinant tissue plasminogen activator.
Focal microvascular cerebral amyloid angiopathy was also observed in the deep cortices and the white matter of the dogs and a woodpecker.
Focal MRCP activity in response to repetitive grasping resulted in minimal changes ( i.e. Block @number@ versus Block @number@ ) in older adults.
Focus depends on survival and sequelae , determined after years of follow-up.
Focused cold therapy seems to be an effective , safe nontoxic alternative to popular wrinkle-reducing treatments.
Focused efforts at cognitive training / rehabilitation also appear potentially helpful but are best established for those with acquired brain injury.
Focused individual and focus group interviews of physicians , nurses and respiratory therapists from the participating hospitals were conducted and analysed to identify common themes.
Focused research is needed to promote efforts in providing adequate and fair access to HPC for all people in Berlin.
Focused strategies to increase the liver donor pool are warranted.
Focus group and interview findings highlight variations in the level of support provided by GPs and access to dietetic , podiatry and retinal screening services.
Focus group discussions were audio-recorded , transcribed , and analyzed using an inductive thematic approach and a social-ecological framework.
Focus groups and interviews were conducted with @number@ staff.
Focus groups ( eight groups with @number@ participants ) and a quantitative national survey ( N = @number@ ) using MTurk were conducted.
Focus groups indicated improved staff collaboration , teamwork , support , and communication when discussing specific responsive behaviours.
Focus groups revealed a need for more training and effective interventions to balance resident safety and autonomy.
Focus groups were also conducted , and transcripts were analyzed using thematic content analysis.
Focus groups were audio taped , transcribed , and coded independently by two researchers.
Focus groups were conducted at @number@ retirement communities.
Focus groups were conducted to explore changes in organizational learning.
Focus groups were conducted to explore student attitudes.
Focus groups were conducted to gain a comprehensive insight on the implementation domain.
Focus groups were digitally recorded , transcribed , and translated using a software coding system.
Focus groups were reconvened to assess progress and health needs over time.
Focus groups were transcribed , coded , and analyzed for emergent themes.
Focus groups were transcribed , coded , and analyzed for emergent themes.
Focus has been placed on characterizing the body's structural changes associated with age and gender.
Focus has therefore been directed towards the role of estrogen in cataract formation.
Focusing on management strategies that address early losses in executive function may be effective in reducing costly services.
Focusing on rare variants , we identified additional association signals for LRRK2 , STBD1 , and SPATA19.
Focusing on respite activities that match caregivers ' unique needs is likely to result in improved well-being.
Focusing on the variety of exposures may be a simple and effective strategy to predict PTSD in FRs.
Focusing on this more tractable deficit of AMD may lead to more effective remediation and technological assistance.
Focusing on what function remains can allow survival predictions to guide decisions on treatment options.
Focus on adequate medical treatment , in particular for cardiovascular disease , is needed.
Focus on operative mortality , symptoms and survival.
Focus on this form of change may aid the search for genetic pathways involved in normal and pre-morbid cognitive ageing.
Focus should be given on correcting misconceptions about adverse events.
FOF is an important health problem that deserves attention in its own right.
FOK judgements were made at each stage for all unrecalled responses , providing a measure of predictive accuracy for semantic and episodic knowledge.
Folate acts through one-carbon metabolism to support the methylation of multiple substrates including DNA.
Folate and the other B-vitamins involved in one-carbon metabolism are associated with cognition in ageing but the evidence is not entirely clear.
Folate deficiency can cause age-related disease.
Folate insufficiency promotes developmental as well as age-related disorders of the nervous system.
Folate insufficiency remained associated with cataract in older men who had adequate vitamin B2 , B6 and B12 status.
Folate intake was estimated by a food frequency questionnaire.
Folate is a vitamin that plays a role as a cofactor and coenzyme in many essential reactions.
Folate metabolism is essential for cellular functioning.
Fold change in atrogin-1 and MuRF-1 @number@ hours postexercise revealed no significant differences between younger and older men.
FoldFx describes how general proteostasis control ( GPC ) enables the polypeptide chain sequence to achieve functional balance in the context of the cellular proteome.
Folding rates follow from a topologically driven rate distortion argument , a model that can , in principle , be extended to intrinsically disordered proteins.
Folic acid can downregulate tau protein phosphorylation by inhibiting the demethylation reactions of PP2A.
Folic acid ( FA ) has been used in studies aiming at disease prevention.
Folic acid is also no longer recommended due to lack of benefit.
Folic acid plays an important role in the maintenance of genomic stability in mammals.
Folic acid up-regulated DNA methylation levels in N2a-APP cells and AD transgenic mouse brains.
Follicle-stimulating hormone ( FSH ) is critical for ovarian folliculogenesis and essential for female fertility.
Follicular fluid ( FF ) lipid peroxidation levels were determined through the quantification of malondialdehyde.
Follicular unit transplantation provides a means of restoring eyebrow fullness and architecture.
Follicular waves have now been described in every species in which this approach has been used , including humans.
Following 6-day dosing , a 26-hour euglycaemic glucose clamp procedure was conducted to evaluate the steady-state pharmacodynamic effects of IDeg.
Following a 90-minute retention interval filled with quiet wakefulness or a nap opportunity , they were asked to free recall and recognize those words.
Following a bleach , which was localised to the stimuli , recovery of sensitivity was measured using a modified method of adjustment technique.
Following a cross-sectional design , scotopic electroretinographic ( ERG ) responses to full-field stimuli were recorded from @number@ subjects with a history of preterm birth.
Following activation , these transcription factors induce transcription of delayed response genes.
Following acute oxidant insult p21 was up-regulated prior to returning to initial levels.
Following adoption of early and non-CD4-guided treatment initiation , their long-term clinical outcome is expected to improve.
Following a familiar life course arc , older people should hypothetically release the possessions that equipped the daily lives that they no longer have.
Following allostasis theory , allostatic load represents accumulated physiological and somatic damage secondary to stressors and senescent processes experienced over the lifespan.
Following an increase in length and width during childhood and adolescence , skeletal growth is generally assumed to stop.
Following an initial 6-week interval , all men were treated with 3-month injections of parenteral testosterone undecanoate for up to @number@ years.
Following an introduction to worm biology , the Review provides examples of current research with C. elegans that is chemically relevant.
Following an overnight fast , patients swallowed the SB-VCE with a glass of water.
Following an unsuccessful attempt at self-report from a nonverbal older adult , the potential causes of pain should be explored.
Following a phenomenological design , data were coded and analysed for experiences.
Following a review of the titles , abstracts and reference lists , @number@ articles remained and were assessed for eligibility.
Following a trip , older adults take longer than younger adults to recover steady-state walking.
Following audiometric evaluations , participants underwent MRI while performing a speech perception task at different intelligibility levels.
Following Aβ oligomers , we detected synaptic alteration , tau hyperphosphorylation and glial activation.
Following both SMT sessions , they repeatedly practiced a 5-elements sequential finger-tapping task ( FTT ) .
Following ChEI treatment , perfusion increased in temporal and parieto-occipital cortex , and cognitive performance improved on a verbal fluency task.
Following cognitive debriefing interviews , the FLSQ-Baseline version included @number@ items and the Follow-up version included @number@ items.
Following conversion to dementia / MCI , higher education predicted steeper declines in cognitive function ( p < @number@ ) .
Following critical illness , physical functioning ( PF ) may be impaired for up to @number@ years.
Following detailed analysis key processes emerged as being central to delivery of compassionate care.
Following differentiation during fetal development , β cells further adapt to their postnatal role through functional maturation.
Following DNA replication , nucleosomes are then reassembled onto replicated DNA using both parental and newly synthesized histones.
Following each play participants completed a reaction form and participated in a short discussion about the play's content.
Following each presentation , a focus group discussion took place.
Following elevation of the skin flap in the temporal area , the lateral portion of the orbicularis oculi muscle was partially elevated and splayed.
Following embryo transfer , a healthy baby was delivered.
Following embryo transfer , one patient became pregnant and delivered a healthy baby boy , with three other embryos under cryopreservation.
Following endotracheal intubation and inflation of the cuff with the head and neck in a neutral position , the intracuff pressure was measured.
Following exposure to H2O2 , ALC1- / - cells showed compromised chromatin relaxation.
Following exposure to MMS and to H2O2 , the ALC1- / - TK6 cell line showed a delay in single-strand-break repair.
Following focal cerebral ischemia , brain capillary cells are enabled to sprout.
Following heat acclimation relative decreases and increases in Tr and Msw , respectively , were similar in both subject groups.
Following HIT in older adults , MiD49 and Mfn2 levels were not different in whole muscle and Mfn2 content decreased in type II fibres.
Following immunohistochemistry , CYP11B2-expressing area and areas of abnormal foci of CYP11B2-expressing cells , called aldosterone-producing cell clusters , were analyzed.
Following improvement in liver function , the urea , nitric oxide , methionine , and polyamine cycles were accelerated.
Following intervention , SCM thickness measurement in the CCF group showed no significant changes.
Following inverse normal transformation of the residuals , seqMeta was used to conduct race-specific single-variant and gene-based association tests while adjusting for population structure.
Following ischemic insult , HEPM induced a significant reduction in infarct volume and subsequent neurological deficits , compared with EAEPM and MEPM.
Following KD , soluble Klotho reversed the effects of Klotho deficiency.
Following LTx , biventricular dilatation reduced and biventricular systolic strain improved.
Following menopause , the vulva and vagina atrophy.
Following mRNA extraction beta-actin real-time PCR was carried out using a set of @number@ different primer / probes to assess mRNA quality and quantity.
Following @number@ months of estradiol administration , bilateral posterior hippocampal voxel-based gray-matter volume was increased in women who received 2-mg estradiol.
Following @number@ months of post-surgical growth , we assessed variation in facial form using linear measurements and principal components analysis of Procrustes scaled landmarks.
Following @number@ weeks of pharmacotherapy , GAD participants had greater connectivity between the dlPFC and several prefrontal regions during worry reappraisal.
Following overnight fasting , basal serum levels of mBDNF and tBDNF were assessed ( human ELISA kits ) at baseline and post-intervention.
Following peripheral exposure , many prions replicate within the lymphoid tissues before infecting the central nervous system.
Following practice , all participants were then posttested under the ID = @number@ Fitts conditions.
Following pre-treatment with the Src inhibitor , PP2 , both HA production and HAS2 expression were attenuated.
Following RNAi-mediated knockdown , @number@ of the genes modulated mitochondrial dynamics in human neuronal cultures and four candidates enhanced α-synuclein-induced neurodegeneration in Drosophila.
Following scanning , samples were stained for sGAG with toluidine blue.
Following spine surgery , complication rates are higher in patients with PD than in those without the disease.
Following standardized exposure to doxorubicin to induce experimental cardiomyopathy , cardiac function and survival was significantly improved in the transgenic mice.
Following successful pharmacologic treatment , we observed greater connectivity in the prefrontal nodes of the Executive Control Network during reappraisal of worry.
Following surgery BuChE activity was lower in the delirium group but this difference disappeared after controlling for preoperative values.
Following the 5-week intervention , AIT exhibited higher enhancement of V̇O2max than did MCT.
Following the 5-week intervention , HET exhibited higher enhancements of peak work-rate and cardiopulmonary fitness than NET did.
Following the baseline audit , an intervention comprising prescriber feedback , group education and individual case-conferences with prescribers , and patient education mail-outs was implemented.
Following the common practice , we predict if a subject has the apnea-hypopnea index greater then @number@ or not as well as @number@ or not.
Following the diagnosis of CLL in an elderly individual , careful risk assessment is essential when treatment options are evaluated.
Following the diagnosis of PES , patients ' survival was up to , and beyond , @number@ years.
Following the enactment of Medicare in @number@ access to health care for older adults in the United States improved.
Following the exclusion of L'Aquila due to @number@ earthquake , final analyses included @number@ subjects.
Following the exclusion of neuropsychiatric diagnoses from comorbidity adjustment , between-category differences tended to revert to greater differences.
Following the initial review , @number@ articles did not meet the inclusion criteria for association of frailty and cognition.
Following the introduction of health care targets for cancer , and with an ever-aging population the need for rapid cancer detection has never been greater.
Following their activation , CREB and CRTCs mediate the effects of fasting and feeding signals on the expression of metabolic programmes in insulin-sensitive tissues.
Following the lifelong treatment of fruit flies with CSOL , lifespan was examined.
Following these facts , the modulation of connexin mediated intercellular coupling is suggested as a new antiarrhythmic approach.
Following these symptoms , she showed other changes of character such as lethargy and apathy.
Following the weight loss phase , both groups transitioned to self-selected diet and exercise behavior during a 5-month follow-up.
Following this , a fundamental strategy for manipulating bioenergetics was defined , potential implications studied , and the approach extended to the clinical arena.
Following this , AMH may in the future play a role beyond the scope of female reproduction.
Following this first step , a molecular rearrangement occurs , rearrangement of Amadori resulting to the formation of Maillard products.
Following this information , face recognition accuracy for a set of previously studied faces was measured using a remember-know memory paradigm.
Following this , tendon and muscle shortening / lengthening was computed , and muscle-tendon work was estimated and compared between groups.
Following this , the article considers studies of dementia and social class that focus on lay understandings and biographical accounts.
Following training , acute exercise reduced total wake time by @percent@ and REM onset latency by @percent@ ( P < 0.05 ) .
Following transfection in human embryonic kidney cells ( HEK 293T ) , progeny plasmids were recovered and sequenced.
Following tumor surgery , urinary incontinence challenges prostate cancer patients ' functional health.
Following uric acid administration , there was an accentuated increase in IL-6 during the oral lipid tolerance test ( P < 0.001 ) .
Following viral clearance , the RSV-specific memory CD8 T cells were similar in total number and phenotype in young and aged mice.
Follow-up analyses did not support an association with risk of ischemic stroke and its subtypes.
Follow-up analyses suggested that better mobility was protective against decline in well-being in men but was generally unrelated to changes in well-being in women.
Follow-up analysis indicated that the MCI group had significantly slower dual-task gait speed but did not differ in simple-gait speed.
Follow-up analysis showed those with both NCI and IADL Dependence had lower moderate PA than those with neither ( p = @number@ ) .
Follow-up assessments occurred @number@ weeks later ( after treatment ) and @number@ months posttreatment.
Follow-up assessments were conducted after @number@ @number@ @number@ and @number@ months.
Follow-up averaged @number@ ± @number@ years ( @number@ patient-years ) and was @percent@ complete.
Follow-up averaged @number@ y.
Follow-up began after @number@ years of therapy.
Follow-up control experiments in aged rats suggested that intrusions in older animals reflected general interference , independent of context manipulations.
Follow-up data , including survival status , were collected after @number@ @number@ and @number@ years.
Follow-up data were obtained up to @number@ year after the baseline examination.
Follow-up duration : @number@ ± @number@ months.
Follow up duration ranged from @number@ to @number@ years.
Follow-up echocardiography was performed in @number@ patients following LTx and in @number@ patients who did not undergo LTx.
Follow-up examinations ( identical to baseline ) will be performed after @number@ and @number@ years , and in 10-year intervals thereafter.
Follow-up examinations were performed three times with 7-year intervals.
Follow-up ( FU ) visits were @number@ and @number@ months following the final treatment.
Follow-up health status , number of supporters and social activities , and self-rated active ageing also significantly predicted QoL at follow-up.
Follow-up included assessment of therapy details , recurrence , vital status , and cause of death.
Follow-up included @number@ of the baseline sample.
Follow-up interviews , including instruments for ADLs , were conducted @number@ month after ICU discharge.
Follow-up longitudinal assessments on this cohort will provide insight as to how these polymorphisms may affect the risk of cognitive decline over time.
Follow-up losses were only observed for the variable age group ( p = @number@ ) , and predominantly for those aged @number@ years or more.
Follow-up-measurements were carried out after @number@ @number@ and @number@ months to assess potential immediate and maintained effects of the intervention.
FOLLOW-UP : @number@ weeks.
Follow-up occurred in either secondary schools or individuals homes.
Follow up of adult patients with phenylketonuria is performed in internal medicine centers specialized in metabolic diseases.
Follow-up of the patients of this group for one year revealed that results obtained by EMFs treatment are still remaining.
Follow-up of this cohort over longer periods will elucidate robust predictors of future cognitive decline.
Follow-ups are conducted every five years when the new cohort is initiated.
Follow-up showed improvement in lipid profile and bone mineral density in severely persistent GHD patients under GH therapy.
Follow-up studies included chain reaction ( RT-PCR ) , immunohistochemical staining and enzyme-linked immunosorbent assay ( ELISA ) .
Follow-up studies in humans revealed that auditory measures varied as serum aldosterone levels shifted within the normal range , in otherwise healthy older subjects.
Follow-ups using the same procedure were conducted in @number@ and @number@
Follow-ups were conducted in 1974-1975 , 1980-1981 , 1992-1993 , and 2000-2001.
Follow-ups were conducted in @number@ ( n = @number@ ) , @number@ ( n = @number@ ) and @number@ ( n = @number@ ) .
Follow-up time and age were used as proxy variables for aging and gait speed as frailty marker.
Follow-up time was @number@ years ; the endpoint was mortality.
Follow-up visits are scheduled every @number@ years , and in between participants receive follow-up questionnaires.
Follow-up visits to all the patients kept in the following @number@ to @number@ months.
Follow-up visits were completed at @number@ @number@ and @number@ weeks @number@ and @number@ months.
Follow-up visits were done at second , third , and sixth months.
Follow-up was at least @number@ months.
Follow-up was at three days , one week , @number@ weeks , and one month , three months , and six months after treatment.
Follow-up was available at @number@ months and @number@ and @number@ years after treatment.
Follow-up was complete until @date@ .
Follow-up was monthly for up to @number@ months.
Follow-up was @number@ ± @number@ years.
Follow-up was obtained in @number@ ( @percent@ ) patients ; of them @number@ patients were deaths with a survival time of @number@ ± @time@ .
Follow-up was performed at 7-15 days and 1-3 months after surgery.
Follow up were lost in two patients after operations.
Follow-up within group comparisons revealed significant age-related thinning in the autism spectrum disorders group but not in the typically developing group.
Follow-up work is needed to examine if these effects contribute to reduced stability in aging.
Food addiction ( FA ) diagnosis was found to be higher in adults aged > 35 years , females , and overweight / obese participants.
Food bioactives are known to prevent aging , cancer , and other diseases for an overall improved health of the consumer.
Food contamination by pathogenic microorganisms has been a serious public health problem and a cause of huge economic losses worldwide.
Food diversity may be a potential indicator to measure nutritional status in women.
Food groups were determined by 24-hour recall using the validated USDA Automated Multiple-Pass Method.
Food insecure participants showed comparable ( re ) fill adherence to food secure participants.
Food insecurity is a nutrition-related factor that coexists with obesity among low-income individuals.
Food insecurity is a pressing issue in the United States where one in six people suffer from hunger.
Food insecurity is associated with peripheral arterial disease among older adults ( adults adjusted odds ratio , @number@ [ @percent@ CI @number@ @date@ ) .
Food insecurity refers to the condition in which individuals do not have access at all times to enough food for an active , healthful life.
Food insecurity status was determined by ≥3 affirmative responses on the 10-item US Department of Agriculture Food Security Scale ( FSS ) .
Food insecurity was assessed using a six-item validated standard measure.
Food insecurity was not independently associated with low CD4 counts.
Food intake was also measured at those time points.
Food intake was recorded by means of a validated food frequency questionnaire.
Food is an important part of any living arrangement and an essential component for quality of life.
Food must be energy and protein enriched , because dilution is needed for preparation , and several meals like bread can be removed.
Food patterns were derived from principal component analysis.
Food preferences may influence food intake.
Food restriction causes a set of physiological changes that reduce the rate of aging.
Food security was assessed using the US Household Food Security Survey Module.
Foods may offer a mechanism for intervention complementary to drugs , devices , biologicals and vaccines.
Foods tested were Japanese soy sauce , coffee , cola , and red wine , all of which showed fluorescence characteristics of AGE.
Food supplement intake did not change serum IGF1 levels significantly.
Foot clearance may be related to physical fitness , which differs between active and sedentary participants , and be acutely affected by exercise.
Foot clearances were compared before and after exercise and between the groups.
Foot function was categorized as normal , pronated , or supinated using the center of pressure excursion index from dynamic pressure measurements.
Foot function was categorized as normal , pronated or supinated using the centre of pressure excursion index derived from dynamic foot pressure measurements.
Foot pain is highly prevalent in older people and has a significant detrimental impact on mobility and quality of life.
Foot pain , particularly related to shoes , footwear and rheumatic disorders , may be an important modifiable factor.
Foot posture was categorized as normal , planus , or cavus using static pressure measurements of the arch index.
Foot posture was categorized as normal , planus or cavus using static weight-bearing measurements of the arch index.
Foot pressure increased in lesser toe ( LT ) right after crossing the obstacle ( p < 0.05 ) .
Footwear interventions , including shoe insoles and foot orthoses , have the capacity to enhance balance control and gait in older people.
For 54 / 190 items ( @percent@ ) , a unanimous response was achieved as to the original author-based FORTA label choice.
For a 3m walking speed we used the cut-off point of the EWGSOP definition.
For a better understanding of the curative strategies of face aging , the authors have put into perspective the three-dimensional data acquired up to date.
For a better understanding of these age-associated modifications , animal models as close as possible to humans are needed.
For a causal hypothesis to be considered \ "likely \ " pathogenic to AD , support from all three postulates is a requisite.
For access to other quizzes , go to www.asrt.org / store.
For access to other quizzes , go to www.asrt.org / store.
For a center of pressure ( COP ) time series , the complexity measure represents the stability of postural control.
For a century , nephrosclerosis was ascribed to nonmalignant hypertension and aging.
For a convincing substantiation of such mechanism it is necessary to show , how attenuation of bioenergetics causes the basic nocuous processes accompanying aging.
For additional information , see Resources for Nurses.
For a definitive recommendation for one of these approaches , further studies with appropriate sample size are necessary.
For adherence , drop-out rates and session attendance were compared.
For AD , higher HOMA-IR predicted lower FDG in all ROIs.
For adolescents , for example , affective well-being in the morning was worse the shorter participants had slept the previous night.
For adults aged over @number@ years , however , affective well-being was worse following nights with shorter or longer than average sleep duration.
For adults , no significant associations of network components or correlations with impulsivity were found.
For adults , VirtualDose was compared against ImPACT and CT-Expo.
For a gait speed of < 0.8 m / s , the sensitivity = @number@ and specificity = @number@
For aged crowns with d = @number@ mm wall thickness , load to failure was significantly lower than for the others.
For aggregate scores a repeated-measures analysis of variance was used.
For a given eye , BL thickness was averaged across four central locations by two independent observers.
For a high proportion of reports ( @percent@ ) , prospectively measured health changes in SAH do not concur with retrospectively reported health changes.
For all conditions , RTs were higher for elderly adults.
For all demographic groups baby boomers had higher odds of death due to accidental poisoning than the cohorts that came before and after them.
For all experiments the serum blood of healthy people was used as a control group.
For all four parameters , the PCAs revealed a single general factor explaining approximately @percent@ of the individual differences across all eight tracts.
For all groups , loss modulus E \ " was smaller than storage modulus E'.
For all measures and most time points , the 24-mg / mL cohesive gel treatment groups experienced greater improvements than onabotulinumtoxinA alone.
For all metrics , classification accuracy within @number@ quartile was > 90%.
For all mortality outcomes , there were significant linear tests for trend.
For allocation of participants , a 1 : 1 ratio randomization was performed using opaque envelopes for the concealment of allocation.
For all of them , the observed ADR was lower than expected , and together they accounted for @percent@ of all included colonoscopies.
For all outcomes , the implicit intervention's impact was greater than the explicit intervention's impact.
For all patients , AEs rapidly decreased to low steady levels after 4-5 weeks of treatment.
For all patients , the creatinine level increased from @number@ to @number@ mg / dL and the BUN increased from @time@ @time@ mg / dL.
For all pre-test , post-test comparisons on Likert scale , Wilcoxon Signed Rank Test was used.
For all studies , either individual patient data and / or published data ( aggregate data ) were available.
For all subjects , contrast thresholds were assessed in Maxwellian-view.
For all subjects the a posteriori probability to develop dementia was estimated using the classifier in a cross-validation experiment.
For all the impulses ( n = @number@ @number@ rightward and @number@ leftward ) , VOR gain decreased as head impulse velocity increased.
For all the patients a uniform questionnaire was fulfilled on admission.
For all the quantification methods , the concentration of cf-DNA was significantly higher ( p < 0.05 ) in nonagenarians as compared to controls.
For all women , AMH was found to decrease by @percent@ per year.
For a major osteoporotic fracture , the median probability was lower by @percent@ at age @number@ years and the difference increased with age.
Foram calculadas as frequências dos códigos CoDe das causas do óbito em cada categoria de classificação.
For a minority of patients , a risk of sudden death was associated with more severe neurological impairment.
For an adequate definition of SE , it is essential to disentangle these relationships between causes ( employment ) and effects ( employability ) .
For analyses , all markers were grouped by quartiles.
For analyses it was used Square-Qui Test considering the level of significance of @percent@.
For analysis of age distributions , patient samples were split into four age categories from ' 20-29 years ' to ' @number@ years and over'.
For a national measure , a weighted average of the estimated prevalence was used.
For an illustrated summary of this Primer , visit : @url@
For an overall description of gait , spatio-temporal parameters were also obtained.
For a particular fasting glucose level HbA ( 1c ) level was higher in older age groups ( p < 0.001 for linearity ) .
For a reach-to-grasp reaction to prevent a fall , it must be executed very rapidly , but with sufficient accuracy to achieve a functional grip.
For ASEAN countries , UHC should be explicitly considered to mitigate deleterious effects of economic integration.
For Asian populations , HPV vaccines enhance the level of HPV16- and HPV18-specific antibodies for both uninfected and infected individuals.
For a similar fracture risk , participants with DM had a higher T score than participants without DM.
For assessing the level of physical fitness , a test was performed to measure the indirect maximum oxygen consumption.
For a subset ( n = @number@ ) we included immune activation markers to examine mediator effects.
For athletes and coaches , an increase in participation and a continuous improvement in performance can be expected in these age group athletes.
For atorvastatin , an association was found in users with a starting dose of more than @number@ mg.
For atorvastatin users no significant association was found.
For balance , there was no significant difference regarding sex , but there was a difference regarding age ( P < @number@ ) .
For ' becoming less healthy ' trajectories , dietary quality appeared to worsen from @number@ years of age in both cohorts.
For beneficiaries with cancer , supplemental insurance effects were similar in magnitude yet negative , suggesting little net effect of supplemental insurance for cancer patients.
For between-day reproducibility there were no significant differences between days for free Achilles tendon mechanical properties.
For bioelectrical impedance analysis , the range was from @percent@ to @percent@ in men and @percent@ to @percent@ in women.
For biopsies of cancerous lesions , high-grade cancer , bilateral disease , and perineural invasion decreased the rate of ordering in both groups.
For both , appearance reasons for tanning and sociocultural influences on tanning were positively associated with appearance orientation.
For both ART-naïve and ART-treated HIV-1-infected adults , a renewable pool of thymic emigrants is necessary to maintain CD4 ( + ) T-cell homeostasis.
For both delta and theta , the proportion of energy in the first NREMP declined significantly across ages @number@ to @number@ years.
For both diseases , vector control is the only tool for preventing epidemics since no vaccine or specific treatment is available.
For both ERα and SFRP1 , percentage methylation was significantly higher in the rectum than in the right colon ( P = @number@ ) .
For both genders the most important prerequisite for parenthood was having a partner to share responsibility with.
For both gender , the frequency of PTPN22 T1858 carriers does not differ significantly in nona / centenarians and in octogenarians respect to young group.
For both groups , INT increased and IOR decreased with task demand ; while NP remained stable.
For both hands and feet , mean RT and its variation increased with age.
For both infection groups , increases over time were attenuated after age-standardisation , indicating that these rises were largely due to population aging.
For both knee angles , young men produced peak power at @number@.3±9.0% MVC , whereas the old men produced peak power at @number@.8±7.9% MVC.
For both methods , fractional anisotropy , along with the mean , radial , and axial diffusivity parameters , was computed.
For both models adjustments were made for age , gender , lifestyle factors , depressive symptoms , and socioeconomic factors.
For both muscles , an optimal tendon compliance ( tendon strains of approximately @percent@ with maximum isometric force ) existed that minimized metabolic energy consumption.
For both older patients and patients with chronic renal insufficiency , the most important drug-related adverse effect to avoid is hypoglycemia.
For both parties , this dual positioning shaped their investment in the project and valuing of its possible outcomes.
For both scoring systems , higher scores connote greater adherence.
For both sexes , individuals who experienced more cumulative abuse have a greater risk of developing MetS.
For both subjective and partially occluded contours , interpolation was affected more by support ratio than absolute size.
For both substrates , significantly greater collagen exposure was observed after @number@ months in water.
For both techniques results were consistent for all facial sites.
For both the intertubular and peritubular components , the capacity for dampening was significantly lower in the old group.
For both traits , optimism fully explained the associations with FSRH.
For both tune and fact recognition , three presentations were beneficial.
For both types of surfaces ( large and small ) , the participants were able to judge surface shape reliably.
For both women and men BV / TV decreased significantly with age , Tb.Th was independent of age , while SMI increased significantly with age.
For both young and elderly participants , the sit-to-stand duration and the shear forces were greater in the far condition.
For both younger and older listeners , spatial separation increased the costs associated with performing both tasks together.
For bread , there was insignificant difference in willingness rating to consume low-sodium option ( p = 0.375 ) .
For breast cancer patients , the corresponding pooled estimates were @number@ ( @number@.49-0.78 ) and @number@ ( @number@.38-0.84 ) , respectively.
For California , this represents an @number@ percent relative decline in elderly nursing home utilization.
For cancer and diseases of the circulatory system , increase in life expectancy was associated with relatively younger age at the time of death.
For cases in which teeth are unavailable , analyzing AAR in purified elastin has been shown to be an alternative method.
Forced differentiation of human glioma spheres reduced SPP1 expression.
Forced expression of active HSF1 in cells resulted in an increase in c-Jun expression and activation of c-Jun target genes.
Forced expression of CDC25C affected cell-cycle progression but did not affect sensitivity to cellular stress.
Forced oscillation is easy to perform and provides information complementary to spirometry.
Forced overexpression of Sirt1 partially rescued the PCa cells from melatonin's antiproliferative effects , suggesting that Sirt1 is a direct target of melatonin.
For cells that were inherently resistant to apoptosis , cell death distinct from apoptosis was induced.
Force measures showed reduced peak forces in AP accompanied by less loss of force between conditions compared to YP.
Forces in various parts of the spine were then calculated and correlated to deformity progression and growth modulation ( GM ) changes.
Force to distance analysis demonstrated a dependence on age.
Force was computed from Young's modulus and longitudinal aortic strain ; work was the integrated product of force and annulus displacement during systole.
For children ≥7 years , significantly more goals were identified on activity and participation ( A & P ) domains ( @percent@ ) .
For children born to cohabiting or noncoresident parents , we find little evidence that subsequent family structure experiences are associated with socioemotional development.
For children born to married parents , we find associations between family instability and poorer socioemotional development.
For children receiving combination MTX-biologic therapy , @percent@ of respondents preferred stopping MTX first.
For children with ADHD , poorer working memory performance predicted parent report of child learning problems.
For China's future health system , efforts should be made to improve community capacity to provide integrated services to senior citizens.
For colorectal , lung and stomach cancer and skin melanoma , all the indicators were higher in men than women.
For color stability testing , provisional resin disk specimens of the above mentioned materials were fabricated.
For common variants , we used linear regression to test for association between genotype and cognitive performance with adjustment for important covariates.
For comparability , each vertebra was treated bilaterally with pedicle screws , augmented and non-augmented.
For comparison between the two age groups , over age @number@ and under age @number@ seizure times were transformed into circular variables.
For comparison , frailty was also assessed using the same method based on grip strength and manual TUG time.
For comparison , @number@ matched control subjects were included.
For comparison purpose , data from a population based survey in Germany were used.
For comparisons between clusters , multivariate analyses of covariance were used to test the differences in lifestyle behaviors.
For comparison , the conventional method of collecting aerosols into dichlorofluorescin ( DCFH ) aqueous solution was used as a reference.
For comparison , the young biceps brachii was examined.
For comparison , vitamin E was also tested.
For comparison , we further included @number@ patients with probable AD.
For comparison with current practice , ROC curves relying solely on percent weight loss were also calculated.
For complete cycles , repeat SET could produce more live births per egg retrieval than repeat DET.
For composition , collagen content , mineralization , carbonate substitution and mineral crystallinity were evaluated.
For controllability of MI , older adults showed alterations in imagining body postures.
For control purposes , voluntary steps , in response to vibration cues on the forehead or occiput were also recorded.
For correction of the aging face , surgeons are devising more procedures with fewer incisions and shorter postoperative recovery periods.
For cost-effective screening for tau pathologies in neuropathologic practice , examination of the hippocampus , amygdala , and basal ganglia is recommended.
For CPS , the OR for UI from \ "borderline intact \ " to \ "very severe impairment \ " was @number@ - @number@
For crow's feet , the members recommended three injections per side ( @number@ U / side ) at the lateral part of the orbicularis oculi.
For DAFS , change from baseline immediately postintervention was @number@ ( P < 0.001 ) , although retention was not as strong.
For data analysis , grounded theory was employed by utilizing MAX QDA2.
For daughters , change in caloric intake was related to change in waist circumference ( β = @number@ p = @number@ ) .
For decades , angiotensin converting enzyme inhibitors and beta blockers have been the mainstay of HFrEF therapy.
For decades , cyclosporin A ( CsA ) has proved to be safe and effective for use in transplantation.
For decades , electroencephalography ( EEG ) has been a useful tool for investigating the neural mechanisms underlying human psychological processes.
For decades mitochondria have been considered static round-shaped organelles in charge of energy production.
For decades , several axioms have prevailed with respect to the relationships between the CNS and circulating immune cells.
For decades the magnitude of the hyperthermic response in heat stroke patients was considered the primary determinant of morbidity and mortality.
For dentin , higher demineralization was observed around the aged composite restorations regardless of the dentifrice type used.
For depressive symptoms , a reduction in mean score of @number@ was found for each year of increase in age.
For depressive symptoms , clinically significant improvement was found for @percent@ of PEP vs @percent@ of IS participants.
For depressive symptoms , wives ' scores predicted subsequent depression increase and memory decline among husbands.
For disability benefit and unemployment , absolute risks were lowest in Southern European welfare state regimes.
For discriminant validity , the discriminant power of the AAQ in terms of gender and education levels was evaluated.
For discrimination of musical excerpts , MCI and AD patients surprisingly performed significantly better than the healthy comparison subjects.
For downward support from parents to children , the results differed depending on the type of support.
For DT walking the differences between preferred and fixed gait speed have to be controlled to assign the DT effects.
For DY only , @number@ distributions significantly ( P > .99 ) improved the description of individual treatment data.
For each activity , sizeable proportions ( 18-34% ) disagreed about participation.
For each age group , we defined patients with a baPWV above the mean + SD baPWV for the group as the high-baPWV cohort.
For each age , the BVL / year was derived from the age-volume curves.
For each case , four age- and sex-matched controls were selected using incidence density sampling.
For each case , GBM thicknesses at 10-15 evenly distributed points per glomerular loop were directly measured and the arithmetic mean ± SD was calculated.
For each class , the total population was divided into two subgroups according to the presence or absence of the corresponding class.
For each condition , participants rated the experienced listening effort and estimated their performance level.
For each dataset , our experiments demonstrated that both classification algorithms performed considerably better when preceded by the training set modification step.
For each DB , we first identified secondary sources of literature , namely , clinical summaries , clinical practice guidelines , and systematic reviews.
For each decade of aging , ESR and CRP levels became @number@ and @number@ times higher , respectively.
For each diagnostic group , Kemp Quality of Life Scale responses were divided into low , average , and high QOL subgroups.
For each dimension also influencing factors , effective interventions and knowledge gaps were inventoried.
For each disease , the appropriate algorithm was used to classify participants ' disease status ( positive or negative for disease ) .
For each femur , DXA / aBMD was assessed and a QCT / FEA model was developed to estimate femoral stiffness and strength.
For each frequency , the resulting torque response of the ankles was decomposed into elastic and viscous components of the total stiffness.
For each groups , the cases were divided according to the age ( 19-40 , 6-40 years , over @number@ years ) .
For each group , the MBI consisted of weekly 90-min sessions for @number@ consecutive wk , directed by a psychologist.
For each HRQoL domain , significantly higher scores were observed for the control group compared with the stroke survivors , at P < 0.05.
For each hypothesis , we discuss the potential implications.
For each IAT , the authors examined their technological type , application , target population , model of development , and evidence of clinical validation.
For each imaging modality , brain regions associated with each cognitive domain were generated by adaptive regional clustering.
For each individual , a single summary daytime cortisol level was estimated by fitting a marginal longitudinal model for the @number@ time-stamped cortisol samples.
For each landmark the mean , standard deviation , P value , and lower and higher @percent@ confidence intervals were calculated.
For each measurement , we calculated the mean value from the @number@ observers and evaluated interobserver agreement.
For each medicine used , the cheapest equivalent available was also identified.
For each model , normal as well as mutant , FBC yielded remarkable inhibition constant values , with exothermic free binding energies.
For each of them , some factors are more influential than others.
For each of these variables , the significant associations remained after controlling for other potential confounding variables.
For each outcome , prevalence was estimated in relation to annual household income ( @number@ categories ) .
For each outcome , trends were also stratified by age categories because the risk of infection and associated mortality increases with age.
For each outcome variable of interest , we developed separate regression models.
For each patient , APACHE II score , time of hospitalization and mortality , blood levels of lactate were collected.
For each patient , FCRP score was calculated.
For each patient , three controls were randomly recruited from the background population matched for age , sex , and residency.
For each player , we describe a biphasic performance course.
For each problem , they were cued to execute a better versus a poorer strategy.
For each response , participants indicated their level of confidence.
For each Sardinian-specific haplogroup ( SSH ) , we also identified the upstream node in the phylogeny , from which non-Sardinian mitogenomes radiate.
For each scanning session , three or four individual T1-weighted MRI scans were obtained.
For each session , subjects were evaluated pre-and postintervention.
For each session , the subjects were evaluated before and after intervention.
For each speed , participants were instructed to match the self-motion speed described by the moving corridor.
For each stimulus pair , observers were asked to select the facial photograph that they considered to be more youthful in appearance.
For each subject , a linear regression line was estimated through the segmental PreS and SS values.
For each subject , cortical and subcortical grey matter volumes were generated using a parcellation of the volumetric T1-weighted magnetic resonance imaging brain scan.
For each subject , we calculated 10-year cardiovascular risks with and without each risk marker.
For each test condition , the Elderly consistently demonstrated longer step latencies while exhibiting higher head angular velocities.
For each tooth , linear measurements of the neonatal line width were performed on its labial surface at the three levels from the cemento-enamel junction.
For each topic , a brief overview is presented which summarizes the major points discussed by the group participants.
For each trait , the meta-analysis pooled results from up to @number@ prospective studies to examine personality and change in global cognition.
For each trait , we selected all significant SNPs produced from GxE GWAS , and conducted anew the GCTA to estimate the variance they contributed.
For each walking trial , subjects performed a single laterally-directed step to a target on a force plate.
For each , we detail the rationale for its development and explain how to score , analyze , and interpret results.
For each woman , a questionnaire was completed , and 25-hydroxyvitamin D levels were determined by chemiluminescence's immunoassay.
Forearm and leg blood flow were measured by venous occlusion plethysmography.
Forearm / buttock ratios of each molecule were compared for determination of photoaging-dependent changes.
Forearm hyperaemia was matched across all vasodilatating conditions.
For edentulism , age and socioeconomic related disparities decreased over time due to more decline among older and low-income participants.
Forefoot pes cavus is a cardinal sign of Charcot-Marie-Tooth disease ( CMT ) .
Forehead aesthetics described include the aging process , with its contributing factors and consequences , and the ideal brow position in women and men.
Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals.
Forehead lifting serves to restore a more youthful appearance as well as a more functional and aesthetically pleasing brow position.
Forehead taps and lateral accelerations produce more symmetrical effects and showed no significant decline with age.
Forehead taps and lateral pulses evoked oVEMPs in @percent@ and @percent@ of cases.
Foreign body reactions that are seen as inflammatory , sometimes disfiguring , nodules may develop years later at the injection sites.
Foremost among them was Cys5 in βA4 crystallin.
For end-of-life situations , we reviewed cessation of inappropriate drug use.
Forensic age inference was initially based on morphological inspection or radiography and only later began to adopt molecular approaches.
Forensic psychiatrists who perform these evaluations should understand the conceptualization of Neurocognitive Disorders as presented in DSM-5 and how it differs from prior diagnostic systems.
Foreseeable trends in the demand for and the supply of help suggest further evolution in patterns of elders ' receipt of help with care needs.
Forest plot is a popular graphical approach for displaying the results of subgroup analysis.
For estrada singers these differences were @number@ yrs for men and @number@ yrs. for women.
For evaluation , a previously unseen test set was used consisting of @number@ T1-weighted MRI scans with the diagnoses blinded.
For every diopter change towards hyperopia , the average RNFL thickness increased by @number@ μm.
For every ED delirium duration day , the 6-month IQCODE increased @number@ points ( @percent@ CI : @number@ @date@ ) indicating poorer cognition.
For every year they get older get older , men push up when they think people enter later life by @number@.24years , women by @number@.16years.
For evidence-based clinical practice , these high-level risk factors should be taken into account in the prevention of DVT in orthopedic patients.
For example , a basal level of FoxO factors is necessary for cellular homeostasis and these proteins are required for adaptation to exercise.
For example , ablation of several key antioxidant systems has often failed to result in lifespan shortening in C. elegans.
For example , age-related diseases and premature aging syndromes are frequently associated with telomere shortening.
For example , aging-associated disturbances in circadian rhythm are linked to diminished SIRT1 activity , and loss of hematopoietic stem cell function to reduced SIRT3.
For example , amyloid deposition and reduced metabolism is seen early in Alzheimer's disease.
For example , ATP appears to become a more prominent cotransmitter in inflammatory and stress conditions.
For example , caloric restriction is a very strong environmental effector capable of delaying aging.
For example , caveolin-1 deficiency prevents reactive oxygen species-induced cellular senescence despite mitochondrial dysfunction , which leads to senescence.
For example , cross-polar images of picrosirius stained skin reveal exquisite structure , allowing changes in the basketweave conformation of healthy collagen to be assessed.
For example , DNA methylation modifies gene expression without altering the nucleotide sequence.
For example , doses of TRT administered by im injection are typically higher than those administered transdermally , which results in greater musculoskeletal benefits.
For example , elevated plasma concentrations of some sulfonylureas may increase the risk of hypoglycemia.
For example , evidence is mixed as to whether changes in cognitive performance associated with normal aging are exacerbated by cancer survivorship status.
For example , face perception of frontal views remains relatively constant from adolescence through age @number@ with a modest decline thereafter.
For example , females are at greater risk of developing Alzheimer disease dementia , whereas males are at greater risk of developing vascular dementia.
For example , functional limitation levels in one spouse were associated with depressive symptom levels in the other spouse.
For example , fundamental discoveries in skin biology and the advancement of scientific methodologies are enabling step changes in technology in PC.
For example , gene expression is sexually dimorphic during brain development , adult life , and aging.
For example , herbal polysaccharides with considerable anti-oxidant and anti-inflammation capacities have been shown to be beneficial in aging and age-related neurodegenerative diseases.
For example , herein a case was made that bioenergetics is a valid Alzheimer's disease therapeutic target.
For example , hexanucleotide repeat expansions located in a noncoding region of C9ORF72 are the most common cause of ALS.
For example , home remedies were used on @number@ ( @percent@ ) of the @number@ person days for which joint pain was reported.
For example , if 70-year-old respondents perceived themselves as being in better health than others of the same age , it improved their PLO.
For example , in Canada , several provinces have launched age-friendly initiatives.
For example , in hearing loss studies , we expect hearing to deteriorate with time.
For example , in SKBr3 breast cancer cells , PMA hyper-activates the MEK / MAPK pathway , thus inducing p21 and cell cycle arrest.
For example , misfolded Amyloid-ß ( Aß ) and tau proteins are two neuropathogenic hallmarks of Alzheimer's disease.
For example , neutrophil apoptosis is central to the resolution of acute inflammation , whereas autoreactive and virus-infected cells are similarly deleted.
For example , older adults exhibit less segregated resting-state subnetworks relative to younger adults ( Chan et al. , @number@ ) .
For example , one study ( @number@ ) reported hearing loss in rats after long-term and high-dose exposure to sildenafil citrate.
For example , ongoing trials are assessing potential new indications for BoNT-A , including acne and psoriasis.
For example , PDMS undergoes aging easily even in room temperature conditions.
For example , @percent@ of the normative sample obtained one or more scores at or below the 10th percentile.
For example , PGRN mRNA and protein expression are significantly upregulated in brain specimens with HIVE , and in HIV infected microglia in vitro.
For example , recent work from our laboratory showed that perforin-granzyme exocytosis mediates NK-cell killing of senescent cells.
For example , semantically related information is remembered as being closer in space than semantically unrelated information ( Hirtle & Mascolo , @number@ ) .
For example , several long-lived genetic mouse models show attenuation in age-related cognitive decline , adiposity , cancer and glucose intolerance.
For example , simply preventing myocilin glycosylation is sufficient to promote its abnormal accretion.
For example , since anti-aging interventions should be aimed at normal postmitotic cells , no selection for resistance is expected.
For example , smoking rates have dropped and treatment rates for cardiovascular disease have increased-factors that have made the disease less fatal.
For example , some have shown potentially detrimental effects , while others have found improvements on physical function in elders.
For example , structural and functional graph theory features related to default mode subnetworks clustered with the ADHD-Inattentive diagnosis.
For example , the adjusted mean difference ( @percent@ confidence interval ) for @number@ SD increase in WC was @number@ ( @number@ @number@ ) .
For example , the anti-apoptotic function of free radical scavenging proteins supports the pro-apoptotic function of Reactive Oxygen Species ( ROS ) .
For example , the California Verbal Learning Test-Children's Version ( CVLT-C ) and Rey Auditory Verbal Learning Test provide important information about different processes.
For example , the failure / longevity relationship was numerically stronger among people whose causes of death appeared to be preventable rather than non-preventable.
For example the frequency of occurrence of age-related macular degeneration will increase significantly with the ageing population.
For example , the hippocampus is negatively impacted in both OSA and AD.
For example , the lifespan of erythrocytes is about @number@ days and adults make about two million new erythrocytes every second.
For example , the statistically defined distribution of normal ageing brain tissue volumes may be used as a reference to assess patient volumes.
For example , this function is particularly important for elderly people to remember taking medication at the appropriate time.
For example , VEGF accelerates the development of neurons and neural dendritic and axon growth.
For example , when RNA polymerase II transcribes a GAGAG motif it synthesizes at low frequency RNA with a two-base deletion.
For example , with age , all NHPs analyzed to date , develop β-amyloid ( Aβ ) plaques as seen in humans.
For example , women live longer than men yet have more Alzheimer's disease and osteoporosis , whereas men have more cancer and Parkinson's disease.
For example , women performed better than men on the episodic memory test , but there were no gender differences in subjective memory.
For experienced well-being , individual resources were most important at midlife and for groups with lower education.
For faithful cell division , the genome must be replicated and chromosomes and sister chromatids physically segregated from one another.
For family members , awareness was intrinsically linked to their emotional connection with the person with dementia.
For females aged @number@ years and older , the CRC incidence increased by @percent@ annually ( P = @number@ ) during 2000-2004.
For females mated to large males , this reduction became evident for females that mated fifth in sequence.
For females , the increase was from @number@ ( @number@ ) to @number@ ( @number@ ) .
For females the number will increase by @percent@ , from @number@ to 20359 / year in 2015-2019.
For females , the probability of having LVEF < 45% was higher in @number@ ( odds ratio = @number@ ) .
For FEV1 , FVC , and PEF , the corresponding estimates were 65%-67% for additive genetic and 33%-35% for unique environmental factors.
For flexibility , results indicated significant sex differences in mean change trajectories but no sex differences in components of variance.
For follow-up , national register data were reviewed for all diagnosis codes of ischaemic stroke , survival data and causes of death.
For four of the novel variants , the minor allele frequency was low ( < 5% ) .
For four out of ten of these , no reason for PPI use can be identified.
For four studies Poisson and ARIMA models produced higher estimates than Serfling , and Serfling higher than GLM.
For fractional anisotropy , the complementary results of multiple components and variability in component loadings across tracts suggest regional variation.
For frail individuals ( FI > @number@ ) , the estimation of mortality risk may depend more so on intrinsic factors related to their health.
For frailty assessment , @number@ of the @number@ studies focused on the physical frailty phenotype , of which @number@ followed the original Fried phenotype.
For functional independence , there was a difference regarding sex ( P = @number@ ) , but not regarding age.
For future studies , improvement in the following aspects is needed : more rigorous study design and inclusion of multiple factors and their interaction.
For FW and BW shifts , older adults undershot more under dual-task conditions.
For Garvan fracture , risk values were @number@ ± @percent@ and @time@ ± @percent@.
For genotype-phenotype correlations , patients with CF were divided into those homozygous for the DeltaF508 mutation and those with other genotypes.
Forgetting increased across exposures in most cases and older adults experienced more forgetting than did younger adults.
For GH treatment to be considered for anti-aging , improved longevity , organ-specific function , or quality of life should be demonstrable.
For girls , physical activity levels showed positive associations with changes in QUS measures ( p < @number@ ) .
For glabellar lines , the members recommended three injection points ( a total of @number@ U ) .
For global photoaging and ne lines and wrinkles , positive responses were slightly greater in the NFL than in the SSR facial sides.
For GP , nurse and psychiatric care , two-part regressions are used to model separately the probability and the volume of HCU.
For grip strength , the corresponding values were @percent@ and @percent@ in men ; and @percent@ and @percent@ in women.
For group comparisons , we therefore selected CSF samples absent of , or containing only low numbers of blood cells.
For GWAS assumed to be uncorrelated , we adopted the binomial distribution to approximate the statistical significance of the Pleiotropy Index.
For half of them , a visual abstract mask was presented simultaneously.
For half of the participants correct responding led to gains.
For hazard RT , the combined effects of high-density traffic and navigational challenge were more deleterious in good visibility conditions than in fog.
For hCC , this includes cerebral amyloid angiopathy , as well as a disorder resulting in reduced male fertility.
For healthcare practitioners , developing cost-effective strategies that can mobilize social network support remains a critical undertaking in health intervention.
For high risk inducing drugs , monitoring was prescribed in @percent@ ( prior ) and @percent@ ( after ) .
For histology , specimens of common and remarkable types of the EM obtained from @number@ patients were examined.
For historical reasons , senescence is often studied with fibroblast models.
For historical reasons , we suggest naming the entity Fontaine syndrome.
For horizontal forehead lines , the members recommended nine injections in two rows into the frontalis with @number@ U / point.
For hospital nights , the numbers were @number@ and @number@ respectively ( P = @number@ ) .
For how long and in what way should they be followed ?
For HRR and RECQ , only one gene contributed to the significance , whereas for BER several genes contributed.
For human subjects : aging- ( I IV ) and early OArelated ( V VI ) changes in cancellous bone properties were assessed.
For husbands , neither own nor spousal health problems were associated with their marital satisfaction.
For IADL disability , only underweight persons with hypertension were significantly associated ( OR = 1.65 , @percent@ CI = 1. @date@ ) .
For ICU patients , a β-lactam with either a macrolide or a fluoroquinolone should be given.
For IGVoA , the indirect intervention effect on change in activity via change in attitudes towards older adults was reliable.
For IL-6 , clinically significant improvement was observed in @percent@ of PEP participants and @percent@ of IS participants.
For illustration , we apply the model to the data of the Belgian Health Interview Surveys.
For IMS which is non-responsive to standard therapy , supportive therapy specifically artificial respiration followed by recovery is indicated.
For incident disability , FP showed sensitivity = @number@ specificity = @number@ PPV = @number@ and NPV = @number@
For inclusion , reports must report frequency of cardiovascular and bleeding events.
For incomplete AFFs , prophylactic surgical intervention is potentially beneficial.
For individual food groups and nutrients , survivors had a particularly poor adherence to green vegetables and beans , total vegetables , and whole fruits.
For individual links decrease rates up to @number@ per decade are found , in particular for intra-brain links in non-REM sleep.
For individuals exposed to oxidative stress , micronutritional supplementations rich in vitamins and minerals can be also an alternative strategy.
For individuals , work provides meaning , financial security as well as social contacts.
For infants born very preterm ( ≤ @number@ weeks completed gestation ) , there is a high instance of developmental disability.
For instance , a crucial developmental change has been related to cognitive speed in terms of reaction time ( RT ) .
For instance , DDX41 mutations are observed in germline cells long before MDS presentation.
For instance , early-onset \ "geriatric syndromes , \ " such as frailty , have been recognized in these patients.
For instance , health-economic data is used only for pricing in Japan , although it is also used for reimbursement in the UK.
For instance , in entorhinal and prefrontal cortices astrocytes do not mount gliotic response to emerging β-amyloid deposits.
For instance , it is still unknown whether insulin is involved in auditory aging.
For instance , little is known about the working conditions of vulnerable groups such as young and aging fishermen.
For instance , microglia can develop a primed or pro-inflammatory mRNA , protein and morphological profile with aging , traumatic brain injury and neurodegenerative disease.
For instance , S-nitrosylation regulates enzymatic activity of target proteins via inhibition of active site cysteine residues or via allosteric regulation of protein structure.
For instance , the association has an inverted J shape for respiratory causes but is monotonically increasing for diabetes deaths.
For instance , the Pearson correlation between the X-ray images and the height and weight were @number@ and @number@ respectively.
For instance , the sparse visual environment does not map well onto conditions in which a visuomotor transformation would normally be required in everyday life.
For instance , variability in cortical MD may reflect morphological variability more commonly measured by cortical thickness.
For instance , we expect inexperienced surgeons to improve their skills with practice.
For instance , why BRCA1 mutations preferentially lead to breast cancer whereas mutations compromising mismatch repair drive colon cancer is still not understood.
For intellectually disabled individuals , receiving services involuntarily due to severe behavioural problems was a strong predictor of the amount of care received.
For inter-rater reliability of the FMAP , two raters analyzed the performance of a random sample of @number@ participants.
For intra-articular femoral neck fracture , internal fixation or artificial arthroplasty is applied depending on displacement of fracture site.
For intra-hemispheric SC , performance correlated with structural integrity of SLF in young adults and with integrity of UF in older adults.
For in vitro studies , we evaluated protective effects of CA on primary neurons exposed to oligomeric Aβ.
For in vivo study a biofilm infection rat model was performed.
For ISIs longer than @number@ s , older subjects performed less accurately than younger subjects across a wide range of spatial displacements.
For isometric contractions , surface electromyography ( EMG ) activity of the elbow extensors plateaus at near maximal torques ( Le Bozec et al.
Fork activation and histone H4 acetylation , additional early events involved in DNA replication , are not affected by JARID1C downregulation.
For key domains , test-retest reliability was very good , and construct validity was good for all domains.
Forkhead box class O family member proteins ( FoxOs ) are highly conserved transcription factors with important roles in cellular homeostasis.
Forkhead-box class O ( FoxO ) transcription factors regulate mechanisms of cellular aging , including protein quality control , autophagy and defenses against oxidative stress.
Forkhead box O1 ( FOXO1 ) protein has been reported as the link between oxidative stress and AD.
Forkhead box O-class ( FOXO ) proteins are evolutionally conserved transcription factors.
Forkhead box-O ( FoxO ) family transcriptional factors control the expression of many genes involved in a variety of cellular processes.
Fork head box O ( FOXO ) transcription factor is a key player in an evolutionarily conserved pathway.
Forkhead box O ( FoxO ) transcription factors are downstream targets of the serine / threonine protein kinase B ( PKB ) / Akt.
Forkhead box O regulation is principally achieved by two distinct mechanisms : post-translational modifications and protein-protein interactions.
Forkhead transcription factors ( FOXOs ) alter a diverse array of cellular processes including the cell cycle , oxidative stress resistance , and aging.
For Korean women , childhood SES was a significant predictor of functional limitations after controlling for attained SES.
For large-city residents , mediation effects for all mediators were significant and complete.
For leg muscle assessment in young and older women , DTI scanning protocols should consider the amount of time spent in a recumbent position.
For leisure satisfaction , differences were still significant at @number@ months poststroke.
For less educated grandmothers , child care did not have either immediate or lagged effects on cognition.
For life satisfaction , growth mixture modeling identified three distinctly growing subgroups.
For liquidators the type of reaction in the form of increase in LP values at the majority of stimulus in both experimental situations.
For listeners with normal hearing , increasing age was associated with poorer TRTs and slower processing speed but with larger word vocabulary.
For longitudinal analyses , measurements were repeated in blood samples obtained at 8-year follow-up from @number@ participants.
For long term care , medical costs for Zaitaku care was @percent@ less than for hospitalization at the end of life.
For long-term widows , there were no differences compared to married women in daily and general well-being , and a few differences in time use.
Formal care service use is lower and informal care higher in Southern Europe compared to Western and Northern Europe.
Formal case management and collaborative care interventions are likely to provide some benefits.
Formaldehyde ( FA ) , which is said to be a carcinogenic agent , is commonly used in anatomy laboratories.
Formaldehyde , one of the most toxic organic compounds , is produced and processed in human cells.
For male C57BL / 6 mice , age-related decline in muscle force generating capacity seems to occur only at higher relative age than in men.
For males , it was @number@ and @number@ respectively.
For males older than @number@ years , erectile dysfunction ( ED ) is the most common sexual disorder.
For males , the increase was from a mean ( sd ) probability of @number@ ( @number@ ) to @number@ ( @number@ ) .
Formal GEMC curriculum should be considered in training EM residents for the demands of an aging population.
Formalin-free fixatives show improved but varying abilities to preserve nucleic acids and face validation as well as cost barriers in replacing FFPE specimens.
Formal mediation tests suggested that markers of cerebrovascular and degenerative pathology significantly mediated the associations of diabetes with processing speed and executive function.
Formal programs to teach these competencies are lacking.
Formal social support did not mediate the relationship between caregiver burden and QOL.
Formal testing of @number@ patients was carried out.
Formant frequency measures showed no style-dependent differences in vowel production at any age nor any differences in initial stop voice onset times.
For many of these comorbid pathologies , the extent of synapse loss is imperfectly understood but could be substantial.
For many other cognitive abilities , self- and informant-rated methods of assessment are routinely used to guide clinical decision-making.
For many patients , sun damage , trauma , prior cutaneous carcinomas , and aging have created a less than optimal skin appearance.
For many people with type @number@ diabetes , aiming for 20-30% of total energy intake as protein is the goal.
For many species , these new approaches will produce age estimates where this was previously impractical.
For many , this was a time in their lives when they were experiencing renewed sexual desire and enjoyment.
For many women , the group's exclusivity to older lesbians and bisexual women was deeply significant and influenced their decision to attend.
For many years , ageing was considered a process of slow deterioration triggered by accidental environmental factors.
For many years aging research was confined to statistics , psychology , and socioeconomic aspects of old age.
For many years , it has been widely believed that androgen plays an unfavorable role in the development of atherosclerosis.
For many years , there were relatively few research efforts that bridged the fields of developmental biology and cancer genetics.
For many years , those who studied renal disease recognized a strong correlation between diet and disease progression.
For many years , toxicological investigations have shown that the sensitivity of kidney to xenobiotics evolves depending on the stage of life.
Formation and accumulation of AGEs is related with the aging process and is accelerated in diabetes.
Formation of AGEs is increased in response to hyperglycaemia , reactive oxygen species and ageing.
Formation of an oocyte involves a specialized cell division termed meiosis.
Formation of BT antibodies can occur but has previously been reported in cosmetic indications in two cases only.
Formation of cross links with molecular weight of @number@ kDa was observed.
Formation of iisoA2E was found in reaction mixtures of all-trans-retinal and ethanolamine.
Formation of soluble Aβ assemblies is stimulated by monomeric Aβ accumulation in the brain , which has been related to its faulty cerebral clearance.
Formation of such foci was neither accompanied by increased DNA double strand breaks , nor decreased cell viability , nor telomere shortening.
Formation of these protein aggregates leads to AD-like neurodegeneration.
For MCI-progressors , higher HOMA-IR predicted higher FDG in the MTL and hippocampus.
For MDD , there was full overlap between genetic influences at T1 and T2.
For MD , U-shaped paths showing similar patterns were observed , but with fewer maturational effects in some regions.
For measurements in infants , miniaturized probes without loudspeakers were constructed to allow a complete insertion of the probe in the infant's ear canal.
Formed bubbles interfere with the production of nitric oxide which modulates vascular tone resulting in vasoconstriction.
For melanoma , however , results have been fairly consistent showing that longer telomeres are associated with an increased risk.
For men and women , a greater proportion of time was spent being sedentary during later hours of the day than earlier.
For men , intrinsic religiousness mediated the relationship between education and mental component ( β = @number@ p < @number@ ) .
For men , lower T2 cortisol at 45y predicted greater depressive symptoms at 50y and the association strengthened when adjusted for lifetime psychological health.
For men , marital status , mean arterial pressure , physical activity at work and having a chronic disorder were of importance.
For men , none of the motor factors were related to mortality.
For men , only BMI and the combined indicators were associated with hypertension.
For men , the best QOL was associated with high socioeconomic conditions and good physical and psychosocial health.
For men , the most common cancer globally was prostate cancer ( @number@ million cases ) .
For men , there was a significant reduction in depression and anxiety , and an increased sense of social identification with others.
Former athletes who sustained their last sports concussion > 3 decades prior to testing were compared with those with no history of traumatic brain injury.
Former foster youth are at increased risk of housing instability and sexually transmitted infections ( STIs ) during the transitional period following foster care.
Formerly , this was partly due to the low precision of manual counts.
Former smokers who had quit for more than @number@ years scored @number@ points higher ( @number@ % CI @number@ to @number@ ) than current smokers.
For methodological reasons , these differences are not generalizable , but of value for study hypotheses in larger samples.
For mice with acute radiation dermatitis , topical HOCl inhibited the expression of NF-κB-dependent genes , decreased disease severity , and prevented skin ulceration.
For missing teeth , there was less decrement among older and low-income participants , resulting in increased age and socioeconomic related disparities.
For moderate to severe OSAS and severe OSAS , we found waist circumference and both postmenopause stages to be the main factors.
For moderate values of heterogeneity variance model with heterogeneity produces more accurate results in comparison with the model without heterogeneity.
For more dramatic results , ablative fractional lasers can be safely used , although longer healing times and potential adverse effects are to be expected.
For more severe forms of the disease , serum tears and scleral contact lenses are employed.
For more than half a century , scientific research has documented widespread avoidance and even denial of aging.
For more than @number@ years , the free radical theory served as the paradigm guiding most investigations of ageing.
For more than @number@ years , zinc is known to be an essential trace element , having a regulatory role in the immune system.
For more than thirty years , the dog has been used as a model for human diseases.
For most activities , black participants had significantly greater limitations than white participants.
For most characters , hearing loss developed suddenly and was restored by the end of the episode , with only four characters using hearing aids.
For most features of auditory verbal hallucinations , older adults had similar rates to younger persons.
For most health outcomes , more benefits occur with physical activity performed at higher intensity , greater frequency , or longer duration.
For most individuals , moderate exercise is of significant benefit.
For most neuropsychological tests , the dementia classification accuracy of raw and demographically corrected scores was equivalent.
For most of these members , holding social health insurance is mandatory.
For most of these molecules , little or no work has been conducted to determine their biological activity or possible therapeutic effects.
For most parameters investigated linear regressions on age were steeper than described by the ECCS reference values.
For most ( @percent@ ) ADR-related admissions the ADR resolved and the patient recovered.
For MS , increased NfH ( SMI35 ) levels reflect the superimposed presence of further neurodegenerative processes.
Form-space principal component analysis of the morphometric data was used to produce a single metric variable that best explains mandibular-form variation.
For Mt5178A genotypic men , coffee consumption possibly reduced the risk of anemia ( P for trend = @number@ ) .
[ Formula : see text ] peak and CI max were related to exercise cerebral oxygenation-perfusion and cognitive function ( P < 0.005 ) .
Formulating those extracts into dermal gels protected the skin against UV-induced erythema.
For multifactorial interventions , adherence ranged from @percent@ for attending 60 + / 88 of exercise classes to @percent@ for use / repairs of aids.
For musculoskeletal , cardiovascular ( negative association ) , and gastrointestinal disorders this association no longer held when comorbidities were controlled.
For MVPA , questionnaire data in men suggested no further benefit for adiposity markers past @number@ hour / week of activity.
Formyl peptide receptor @number@ ( FPR1 ) is an emerging therapeutic target for the discovery of drugs to treat neutrophilic inflammatory diseases.
For nasal flare , one injection point in the middle of each ala nasi was recommended ( a total of @number@ U ) .
For NC-MCI-AD , the average improvement was @number@ ( @percent@ ) .
For new dentists , student loan debt was the primary barrier to teaching.
Fornix degeneration is a feature of aging and Alzheimer's disease.
For none of the parameters , high-dose vitamin D resulted in a better performance than conventional dosing.
For non-locomotive light activity , however , there was no significant difference between women over @number@ years and younger women.
For non-Māori , the path diagram showed the association between vision loss , and cognitive function was mediated by functional status.
For nonsmoking-related mortality , rectangularization among men did not accelerate around @number@
For @number@ admissions , differences in LOS were greater in older patients and patients with a higher diagnosis-related group ( DRG ) weight.
For @number@ alerts ( @percent@ ) , the pharmacist retrieved a renal function above the threshold for intervention.
For @number@ AS the results from clinical studies were available.
For @number@ g / kg FFM this was @percent@ vs @percent@ ( p = @number@ ) .
For @number@ high-risk patients with other underling pulmonary diseases on general poor conditions , a surgical intervention was performed in awake condition.
For ( @number@ ) H-magnetic resonance spectroscopy , the center of a voxel was positioned in the right parietal lobe.
For @number@ loci , schizophrenia risk alleles were associated with poorer cognitive performance.
For @number@ measures , rho was lower for Blacks.
For @number@ @number@ individuals ( @percent@ ) with such treatment , no underlying rationale was found.
For @number@ of @number@ cancer sites , 5-year relative survival was lower in the most deprived districts than in all other districts combined.
For @number@ ( @percent@ ) of the @number@ Memorial Symptom Assessment Scale symptoms , no age-related differences were found in symptom occurrence rates.
For @number@ week after surgery , the hemoglobin and platelet counts were reviewed.
For @number@ weeks , treated groups received personal training in their respective programs.
For @number@ wk , subjects took daily at @number@ h a capsule of either @number@ mg of progesterone or placebo.
For OA , executive function was correlated with recognition of sad expressions and with scanning patterns for fearful , sad , and surprised expressions.
For older adults , in contrast , the correlation between phasic arousal and incentive sensitivity held for gain incentives only.
For older adults , overall , there was no significant association between visual attention and emotional reactivity.
For older adults , the expected increase in dual-task costs could be confirmed.
For older adults , the impact of increased task demand was greater , and adopting a cautious strategy could help to complete the task safely.
For older adults , the P3 peak amplitude at the Fz site was significantly correlated with the RT of proactive inhibitory control.
For older adults , trajectories are stable over time and predictable , in part , from individual characteristics.
For older adults , treadmill walking was accompanied by significantly more rapid response times and reductions in local- and mixed-switch costs.
For older Americans , accessing high-quality care can be a challenge.
For older compared with younger listeners , acoustic detail had a stronger impact on task performance and alpha power modulation.
For older men and women , the mean ratios were @number@ and @number@ respectively.
For older persons , everyday mobility is an important aspect of living an independent and self-determined life.
For one site in its N-terminal domain , namely K52 , we reported earlier that acetylation completely switches off RhoGDIα function.
For OPIDN which has a different target ( NTE ) than AChE , standard therapy is ineffective.
For optimal life-style campaigns , knowledge of motivators and barriers for physical activity is mandatory.
For optimal patient care and management , the diagnosis of tinea pedis should be verified by microbiological analysis.
For optimal preservation of muscle energy stores , air drying cryosections or cycles of freezing-thawing need to be avoided.
For organs outside scan range or distributed organs , a five times ' difference can occur.
For Otago delivered to persons aged @number@ and older , the net benefit was $ 429.18 and the ROI was @percent@.
For OT , hazards in the home environment was the most powerful predictor of future service provision.
For other ECG parameters ; mean PQ duration , QTc across UCP2 genotypes was not significant ( p = NS ) .
For other relevant care facilities , no firm conclusions could be drawn.
For other smoking-related cancers , the risk was lower.
For others , symptoms interfered with everyday activities , such as exercising , toileting , or sleeping.
For other vitamin-K antagonists regionally used in Europe , the lack of evidence should challenge current practice.
For our analysis we use high quality administrative data from Sweden.
For our sample , cognitive impairment was associated with an increase of morbidity and mortality in the elderly population.
For our study , we defined patients ≥70 years of age as elderly.
For over four decades , the Program of All-Inclusive Care for the Elderly ( PACE ) has been operated by nonprofit organizations.
For paramedics the conflict is between identifying as a rescuer and acting largely as a care giver.
For paramedics the problem is compounded by the newness of its place in the tertiary landscape.
For part @number@ the dentists were classified according to their age ( < ∕≥40 years ) .
For part @number@ the dentists were grouped according to their natural visual acuity.
For patients diagnosed @date@ , we calculated 5-year relative survival for @number@ cancers weighted by age and country.
For patients , relative time to peak was positively correlated with percent stenosis ( P < 0.050 ) , independent of age.
For patients with acute illnesses MIP increased the odds ( OR = @number@ ) that they would use health services.
For patients with a-MCI , negative associations between CR and FA were found in several major tracts , being more robust than in AD group.
For patients with colorectal metastatic liver cancer , the mortality of the young patients was @number@ times lower than that of elderly patients.
For patients with diabetes mellitus the target blood pressure is < 140 / 85 mmHg.
For patients with hallucinations , particularly auditory hallucinations , antipsychotic discontinuation should be approached cautiously because of high relapse risk.
For patients with higher EQ-5D utility , the additional years lived without complications contribute more to longer life expectancy than years lived with complications.
For patients with low and moderate risk , sunscreen only is recommended.
For patients with mild dementia , caregivers provided more assistance in transportation and housekeeping.
For patients with moderate to severe symptoms and a large prostate , combination therapy with α-blockers and 5-ARIs can further improve clinical efficacy of treatment.
For patients with poor performance status , chemotherapy ( temozolomide ) has been shown to be associated with prolonged duration of response.
For patients with severe dementia , family caregivers provided more assistance with personal care , mobility and protection , transportation , and housekeeping.
For patients with very mild Alzheimer's disease ( AD ) , susceptibility to the imagination inflation effect could have significant functional consequences in daily life.
For pCR rates , the ypT0 / is ypN0 definition was used as a primary end point.
For pediatric patients , @number@ cm scan range change can lead to a five times dose difference in partially scanned organs.
For pediatric patients , VirtualDose was compared to CT-Expo and compared to size-based methods from literature.
For people aged @number@ and above , their distribution may be more influenced by the economical factor , decreasing from east to west.
For people at low risk of stroke , anticoagulation is not indicated.
For peripheral quantitative computed tomography ( pQCT ) , single and repeated measurements are particularly adversely affected by movement and positional variation.
For peritumor ( normal ) skin , age , solar elastosis , and adjacent malignancy correlated with greater dilation of lymphatics.
For PGC domains , attitude toward aging and lonely dissatisfaction trended together , while agitation did not.
For photoageing messages , efficacy information was associated with greater message acceptance only amongst self-affirmed participants , but the opposite occurred for skin cancer messages.
For photograph @number@ ( evaluated by only @number@ evaluators ) , the difference was @number@ years ( P = @number@ ) .
For photograph @number@ the difference was @number@ years ( P = @number@ ) .
For physical activity , they were @percent@ and @percent@ in men ; and @percent@ and @percent@ in women.
For physically fit patients , chemoimmunotherapy with fludarabine , cyclophosphamide , and rituximab remains the current standard therapy.
For PM , LMF and GMF , the impact of obesity appeared more pronounced in women , whereas that of underweight more pronounced in men.
For PM steaks , those aged @number@ d had lower WBSF than those aged 2d.
For Position @number@ YA-but not MA-performed significantly better in babble than in quiet.
For postmenopausal breast cancer we report evidence for effect modification by HT use.
For postural control evaluation , strategy scores and approximate entropy ( ApEn ) were computed.
For postural transitions , lower BMI was the unique contributor , explaining @percent@ of total variance.
For potential new therapies it is important to identify patients at risk as early as possible.
For practical reasons , several animal studies use young rodents kept in social isolation.
For preclinical testing of new TKR systems standardized wear tests are required.
For Premium and Silasto @number@ Shore A hardness ranged from @number@ to @number@ and @number@ to @number@ respectively.
For prescribing optimization , results of educational intervention strategies were inconsistent.
For prevalence and incidence rates of depression , odds risk and relative risk ( RR ) were calculated , respectively.
For prevalence and incidence rates of depression , odds risk ( OR ) and relative risk ( RR ) were calculated , respectively.
For prevention of pneumonia in older adults the additional benefit of a concurrent application of influenza vaccine and pneumococcal vaccine should be considered.
For primary care physicians , recognition of frailty might help them provide appropriate counseling to patients and family members about the risks of medical interventions.
For private facilities no notable difference was observed between the groups.
For proper DNA replication , the chromatin surrounding origins needs to be remodeled.
For prospective validation , 3D-CAM assessments were administered by trained research assistants.
For prostate cancer and male lung cancer , the incidence rates increased , reaching a peak , and then decreased.
For PSS-14 , all items ' loadings exceeded @number@ for one of the two factors except item @number@
For purposes of analysis , subjects were divided by age deciles.
For purposes of a replacement therapy based on longer-lasting melatonergic actions , melatonin prolonged release and synthetic agonists have been developed.
For purposes of validity , only peer-reviewed literature was included.
For QoL results showed a significant but slighter improvement.
For RA only , OR ( @percent@ CI ) was @number@ ( @number@ @date@ ) .
For rats of the normal control group , subcutaneous injection of same dose of normal saline was gi-ven.
For realizing the function , we placed RFID readers in the iMec and the recipient's house.
For recurrent cases , selective neck dissection is a safe and effective surgical procedure.
For repetitive trials , this \ "U-shaped \ " relationship was also reflected in the BOLD response in the caudate nuclei and ventrolateral prefrontal cortex.
For replication , we used a more heterogeneous case-control sample from Milano with early and late AD.
For reports of depressive symptoms , but not positive affect , mode effects were more pronounced with age and time.
For reproductive rate , the intersexual correlation and the correlation with fitness were weaker but again similar between the sexes.
For research purposes we believe it necessary to describe the severity of each incontinence subtype separately in subjects with MUI.
For routine uses , AAR is analyzed in dentine.
For safety reasons , the electrode impedance is monitored during stimulation.
For salvage treatment we strongly recommend posaconazole 4×200 mg / day.
For SC patients , additional imaging testing was also performed ( fluorescein angiography and spectral domain optical coherence tomography ) .
For selected comorbidities we also adjust HIV status a priori for age , smoking and body mass index.
For selected skin shade , pores affected the resultant color of prosthesis ( color reproducibility ) .
For self-perceptions of physical change , both groups self-enhanced on being self-sufficient and being part of a larger social group.
For semantically incongruent stimuli , discrimination accuracy was significantly improved during distributed relative to focused attention.
For several cartilage regions , this increase was greater for WB-C than for LWB-C ( p < 0.05 ) .
For sigmoid colon cancer , dissection of lymph node and anastomosis were completed with much difficulty because the pelvic space was occupied with small intestine.
For similar heating durations , aerosol NNR increased from @number@ at @number@ days to @number@ after @number@ days.
For slow gait speed , the cutpoints based on @number@ and @number@ m / s were evaluated.
For small-city residents , only physical and general health were significant mediators , and these effects were partial.
For soleus , no significant differences in thickness were found among the age groups in either sex.
For some caspases ( CASP1 , CASP6 and CASP7 ) these correlations could be related to brain aging.
For some dyads , participation in the study prompted additional communication , resulting in a better shared understanding of ACP engagement.
For some genes , the change in methylation was observed only at specific locations within the promoter region.
For some glutathione transferase genes there is also a correlation between polymorphisms and onset / outcome of neurodegenerative diseases.
For some it facilitates caregiving in the traditional , expected manner.
For some monoclonal antibodies , REE was a better predictor than BW to estimate CL in pediatric subjects.
For some nutrients , the recommended nutrient intakes were already accounted for by the food consumed from the institutional fare.
For some of these participants , uncertainty impacting mental health centred on unexpected survival ; interpretation of one's symptoms ; and medical uncertainty.
For some participants , symptoms primarily affected their ability to have and enjoy sex , as well as be responsive to their partners.
For some patients , phosphodiesterase-5 inhibitors ( PDE5-Is ) or antimuscarinic agents may be added.
For some preterm infants , particularly those with bronchopulmonary dysplasia , obstructive lung disease persists into adulthood.
For some years , policy makers and medical scientists have both begun to focus more on chronic noncommunicable diseases.
For some years there has been evidence at population level that prevention of end-stage kidney disease is feasible.
For specific ability components , the direction and magnitude of age differences depended on the specific ability in question.
For specific health measures there was a consistent linear association with depression , pulmonary disorders , renal disorders , and sensory impairment.
For specificity , the whisper test was highest , followed by the finger rub , indirect , and direct.
For split-face study , HA IDF plus was injected to one side of NLF , and HA IDF was injected to the other side.
For S ( ROD ) , the deficit from normal for age varied significantly with ROP severity but not with age group.
For statistical analyses , independent proportions were compared by Pearson's chi-squared test.
For statistical analyses the mean value was calculated.
For statistical analysis intraclass correlation , paired-samples t-test , Spearman-correlation and Welch-test were used.
For statistical analysis , Student's RESULTS : The elongated styloid process was seen in @number@ of the @number@ patients.
For statistical analysis the assessment of correlation Spearman's rank order and nonparametric ANOVA rank Kruskal-Wallis were used.
For statistical analysis we used Stata @number@ software.
For stomach and cervical cancers , the incidence rates showed a constant decrease.
For studies involving serious risks with potentially greater personal benefits , older adults and informal caregivers were less comfortable with proxy consent.
For studies on healthy individuals , a major concern is that the treatment periods may have been too short.
For study of the directions and ways of tumor spreading in the anterior commissure served @number@ larynx with macroscopic infiltration of anterior commissure.
For subcortical regions this number is between @number@ and @number@ subjects , depending on the region.
For subsequently remembered words , young adults had greater activity at the left and anterior electrode sites , whereas old adults had greater posterior activity.
For successful drug development : @number@ ) appropriate animal models of human age-related diseases need to be devised.
For successful treatment , the practitioner must adopt a humanitarian approach and develop a better understanding of the feelings and attitudes of the elderly.
For such a car without brakes ( and actually without a driver ) , aging from rusting never occurs.
For surgery especially the multidrug-resistant Gram-negative organisms represent an important hygienic and therapeutic problem.
For surgical treatment , bulking agents are a minimally invasive option with adequate short term cure rates.
For SW shifts , larger errors were found for older adults , dual tasking and the most difficult ARD.
For symptom distress , age-related trends were found for lack of energy , shortness of breath , feeling bloated , and difficulty swallowing.
For symptom frequency , age-related trends were found for feeling irritable and diarrhea , with both decreasing in frequency as age increased.
For symptom severity ratings , an age-related trend was found for difficulty swallowing.
For ten years , the nematode Caenorhabditis elegans has emerged as a powerful model to analyze autophagy in physiological or pathological contexts.
For tests that measured attention , reaction time during RVP and CRT was slower ( P ≤ @number@ ) in the older group.
For that , we have resorted to a high-throughput proteomic approach based on isobaric labeling , liquid chromatography and mass spectrometry.
For the activation condition , volunteers viewed sexually arousing visual stimulation.
For the AD and pathology free comparison , results indicated that that AD was associated with poorer performance on the memory and language domains.
For the adult and aging population with preserved cognitive ability , cognitive functioning does not predict decline in speech perception.
For the adult population , ' transition to university ' and ' pregnancy / having a child ' showed probable negative associations.
For the African Americans , there was a similar but non-significant relationship between higher homocysteine levels and dementia risk.
For the amended ISAR-HP sensitivity , specificity , positive and negative predictive values were @number@ @number@ @number@ and @percent@ , respectively.
For the analyses , cross tabulations , logistic regression , and fixed effects logistic regression techniques are used.
For the analysis , the sample was separated into urban and rural groups to account for geographical differences in wait list location.
For the analysis , we propose a practical and very fast trivariate spline smoother to estimate covariate-dependent covariances and their spectra.
For the ankle reflex all four reflex methods examined produced similar results in only @number@ patients ( @percent@ ) .
For the assessment of hip geometry , DXA-based hip structure analysis ( HSA ) and CT-based HSA have been developed.
For the assessment of larynx anterior commissure microscopic status @number@ larynx preparations with macroscopic free anterior commissure were used.
For the association analysis of whole-genome sequencing ( WGS ) studies , we propose an efficient and fast spatial-clustering algorithm.
For the Barthel index , only age and sex were significant.
For the brain nuclei , the age-related changes of susceptibility were in good agreement with the findings from R2 measurement.
For the chroma and lightness , mainly large-scale inhomogeneities in the @number@.8-2 cm ( @number@ ) range are taken into account by the consumer.
For the clinical trials , about @percent@ of the variability of retained restorations could be explained by the adhesive system.
For the cochlear implant recipients , no relationship between the size of the temporal asynchrony window and speech perception performance was observed.
For the combination of FDG-PET and TMT-B , the AUC was @percent@ ( sensitivity = @percent@ , specificity = @percent@ ) .
For the consensus participants , current onabotulinumtoxin A use is a global preventive and corrective treatment.
For the consensus participants , current onabotulinum use is a global , both preventive and corrective treatment.
For the consonant-vowel FFRs , transient onset and offset response amplitudes were smaller , and offset responses were delayed with age.
For the corpus callosum , the effect of age on genu fractional anisotropy was significantly weaker than the relationship between age and splenium fractional anisotropy.
For the covariates sex and independency status , the difference in relative risk of death between groups decreased with advancing age.
For the cross-sectional microhardness test , standardized Class V cavities were prepared and filled with the different restorative systems.
For the current generation , the peak performance tends toward a younger age than the first generation.
For the current study , we included answers from adults aged @number@ years and older.
For the cyclic synthesis of malignancies that are metastasized , a means of xenogeneic bone marrow transplantation is proposed as an alternative therapeutic approach.
For the depression and neuropsychiatric outcome measures , participants with high symptom burden at baseline showed improvement at 1-month postintervention.
For the diagnosis of POCD , pscychometric tests are applied.
For the diagnosis of vascular dementia , at least three zones or strategic areas had to be affected by infarcts , lacunae , or microinfarcts.
For the effective treatment of AD , it would be important to identify MCI patients at high risk for conversion to AD.
For the elderly , parameters which include measures of body composition , fat and fat-free mass are of greater importance than BMI.
For the elderly , the measured values are deduced by extrapolation beyond the range of reference equations which had been obtained in a different population.
For the emergency physician , these agents are used with the explicit goal of preserving vital organ perfusion during acute and severe illness.
For the enrichment of synaptosomes and neuromelanin granules from the same tissue sample density gradient centrifugations using Percoll® and Iodixanol were performed.
For the entire population , the number of shunt revisions in each year of life was determined.
For the entire sample , child care had instantaneous effects on grandmothers ' cognition , although there were no longitudinal effects.
For the entire sample , LARS initiation dimension was related to IGT disadvantageous decision-making profile.
For the equilibrium bleach data , the time constant of recovery increased with age at a rate of @number@ seconds per decade.
For the experimental condition , all participants were faced with a time limit that induced significant stress.
For the experiment was taken a homogeneous group of people which separate populations differ in geographical and climatic parameters of their living conditions.
For the expression and regulation of LIF , reverse transcription polymerase chain reaction ( RT-PCR ) and western blotting were performed in CR-stimulated Ishikawa cells.
For the feedback approach , the perception was assessed with a visual analog scale.
For the females , only the middle cranial fossa and anterior cranial fossa were found to change significantly in shape.
For the field of relative age effects ( RAEs ) in sport , the scientific method appears to be limited to description.
For the final positions ( Positions @number@ and @number@ ) , no age differences or effects of listening condition were found.
For the first @number@ weeks , all participants received the same psychoeducation program via telephone.
For the first time , a 15-year-old boy was found to have a slight degree of proteinuria and microscopic hematuria during annual school urinalysis screening.
For the first time in history , four generations are working together-traditionalists , baby boomers , generation Xers ( Gen Xers ) , and millennials.
For the first time in humans , we demonstrate an interrelationship among AD pathology , small vessel cerebrovascular disease , and cerebral autoregulation.
For the first time in literature , polypharmacy appeared as an associated factor for FI for female older adults.
For the first time , regional anatomical connectivity maps related to processing speed and visuospatial and executive functions in the elderly are identified.
For the first time the present study examines how SOC competencies and depressive symptoms are associated.
For the first time , we show a conclusive contribution of V-LH to the natural variance in male serum LH levels.
For the first time , we show that structure and function of mechanosensory cilia are crucial in maintaining proper cellular proliferation.
For the future acceptance of vascular medicine as a separate subject area under delimitation of cardiology and radiology is important.
For the galactosylated glycoforms the incidence of bisecting GlcNAc increased as a function of age.
For the GPS-iv , a cutoff score of ≥3 maximized the sensitivity ( @number@ ) and specificity ( @number@ ) .
For the group @number@ we recruited @number@ male prisoners aged @number@ and over in @number@ French prisons.
For the identification of expression trends , five regression models were compared and the quadratic model was found as the most suitable for this study.
For the improvement of skin texture , pore size , and sebum secretion , similar efficiency from laser and IPL was observed.
For the increasing aging population worldwide , strategies for the prevention and treatment of SA and concomitant control of comorbidities are very important.
For the independent predictors identified by multivariate analysis , receiver operating characteristic ( ROC ) analysis was performed.
For the intervention phase @number@ other games will be used : Coincident Timing , Motor Skill Analyser , Labyrinth , and Fitts.
For the in vivo part , @number@ patients received @number@ direct resin composite restorations of the same materials in a prospective clinical trial.
For the language comprehension network , we found a more focal activation with age in the bilateral superior temporal gyri.
For the last ten years , new biomarkers of iron physiology lead to better understand physiology and pathophysiology of iron metabolism particularly in iron deficiency.
For the latter , we also evaluated validity by examining correlations with measures of capacity and demographic characteristics ( N = @number@ ) .
For the left hippocampus MD values , there were significant differences between the AD and NC groups and between the AD and aMCI groups.
For the left hippocampus , poor sleep efficiency and greater than five years untreated depressive illness remained significant predictors.
For the maintenance of cognitive health , older adults may be advised to avoid very low sodium diets.
For the majority of cancers , German survival estimates were close to or below those in the United States.
For the majority of older breast cancer survivors , cancer-specific well-being and general emotional health do not change substantially after a breast cancer diagnosis.
For the majority of patients , especially the elderly , the aim of therapy should therefore be a long progression-free survival.
For the males , all anatomic regions reveal significant changes in shape with age except for the posterior cranial fossa.
For the management of sexually transmitted infections in this population , basic epidemiological data need to be established.
For the manual dexterity task no effect was found.
For the men in this study loss of bodily autonomy was a very dramatic experience as it contravened masculine norms.
For the men , the percentage of sarcopenia increase with aging from @number@ @number@ @number@ @number@ to @number@ % , respectively.
For the MIC to exceed the MDC at least @number@ patients are needed.
For the middle positions ( Positions @number@ and @number@ ) , MA performed significantly more poorly than the YA irrespective of listening condition.
For the most natural-looking results , deep volumetric injections at strategic sites are therefore preferred.
For the most part , these processes are controlled by elements in the @number@'-UTR of labile , proinflammatory transcripts.
For the MRT , males scored higher than females , but only in emerging adulthood.
For the MT2A polymorphism , mean ages were estimated as @number@.18± @time@ for G- carriers and @number@.59± @time@ for G + carriers.
For them , the limited but available opportunities for social activities and interpersonal contacts within the facility seem to bring substantial psychological benefits.
For the @number@ detentions , subjects were Caucasian , male ( @percent@ ) and @percent@ were aged @number@ years or older.
For the @number@ most prevalent diseases in the elderly , clustering and comorbidity of chronic diseases in patients @number@ years and older were analysed.
For the @number@ participants with dementia , @percent@ of transitions to nursing facilities were transfers from hospitals.
For the @number@ participants with normal blood pressure at baseline , @number@ had developed hypertension during follow-up.
For the @number@ years and older group , DepE scores significantly increased the risk of poorer CAMCOG-R scores ( odds ratio = @number@ ) .
For the older adults , all EFs significantly correlated with all measures of fine motor control.
For the older patients included in the study , the essential meaning of hospitalisation can be described as feeling an outsider left in uncertainty.
For the old-old , perceived neighborhood quality and outdoor place attachment were more important than for the young-old.
For the other age groups , these effects have yet to be investigated.
For the parameters considered , increasing the reciprocating speed had the most significant effect on cutting rate.
For the parameters that show a significant decrease in performance , the agonist and antagonist systems were affected similarly.
For the past few years , the potential of transcranial direct current stimulation ( tDCS ) for the treatment of several pathologies has been investigated.
For the past several decades , research in understanding the molecular basis of human aging has progressed significantly with the analysis of premature aging syndromes.
For the past several years , there has been much talk and published about \ "The Conversation Project. \ "
For the patients with residual septum , they can be cured by using gastroscopic electrocauterization.
For the PD-mutants , but not for wild-type LRRK2 , endocytic defects were also observed.
For the perceptual evaluation , significant differences in grade of dysphonia , breathiness , and strained vocal quality were found.
For the period 2000-14 , @number@ countries had a very low seroprevalence profile , compared with five in 1975-89.
For the physical domain in WHOQOL , a difference was observed between baseline and visit @number@ ( p = @number@ ) .
For the physician , it is important to choose which drugs or medical devices can be used and in what protocols.
For the PRISMA @number@ the sensitivity = @number@ and specificity = @number@
For the productive network , however , we could confirm an increase with age both in focus and lateralization.
For the professionals of the support social networks , the project should look for intersectoral performance , once it intends to reach a complete attendance.
For the psychoeducation only ( PsyED only ) group , participants received eight biweekly sessions of general discussion of psychoeducation and related information.
For the purpose of normal differentiation of malignant modified daughter cells , it is necessary to block tyrosinase.
For the purpose of this study , @number@ elderly individuals were randomly selected.
For the purpose of this study , only participants @number@ years or older were analyzed.
For the purpose of this study , two separate analyses were carried out.
For the randomised controlled trial , the plan is to recruit at least @number@ community-dwelling persons @number@ years or older from the target group.
For the recipient site , the VIs of the anterior area of the femoral condyle were significantly smaller than those of the posterior area.
For the remaining attribute , coarse wrinkling , approximately @percent@ of the panel showed improvement.
For the remaining \ "Big Five \ " personality traits the results were less consistent across studies.
For the remaining participants incorrect responding / forgetting led to losses.
For the right eye , the aspect ratio had a mean of @number@ ± @number@ in these @number@ subjects.
For the right FI cortex , temporal discounting was negatively associated with functional connectivity to a right cerebellar region.
For the right hippocampus , diabetes and low diastolic blood pressure significant predictors.
For the right hippocampus MD values , there was a significant difference between the NC and AD groups.
For the right versus left task the number of informative lexical features was too small to support any specific inferences.
For the rs16835198 SNP , the variant T-allele tended to show higher luciferase activity compared with the G-allele ( P = @number@ ) .
For the sample as a whole , the failure rates of the Adams desaturated D-15 and the Farnsworth D-15 were @percent@ and @percent@ , respectively.
For these cohorts , the longest part of their additionally gained lifetime will be spent at ages @number@ and older.
For the secondary efficacy endpoint analyses , no significant differences were observed between the two groups for any variable at any point in time.
For the second , a sinusoidal load was applied with an appropriate range of deformation for each material.
For the second point , we refined the data assessment procedures , for each coexpressed gene list and for the total performance of a platform.
For these eight follow-up calls , participants were randomized into either one of the two following groups with different conditions.
For these four \ "roles \ " , we asked : Does membership in a long-lived family protect against disease ?
For these individuals , each standard deviation increase in SPC predicted a @percent@ higher risk of death.
For these individuals , larger GM volumes within regions outside of the infarcted vascular territory may help preserve locomotor control.
For these measurements , there are currently sufficient clinical data showing their association with cardiovascular risk.
For these micronutrients , no disadvantage ( though potential advantage ) was inferred for the water-soluble components presented in a softgel formulation.
For the seniors , the project is quite valid and needs to be consolidated in the district.
For these older adults , engagement in social activities was related to participation in everyday cognitive activities and in turn to better cognitive performance.
For these participants in endurance events , matching energy intake and expenditure is critical to maintain health and performance.
For these patients , our findings argue for the development of therapeutic strategies including the addition of new lymphocyte activation inhibitors to current treatments.
For these reasons , correct diagnosis and well-conduct preoperative plan are necessary to improve stability of fractures and support bone healing.
For these reasons , dementia in Japan has become common , and more than half of all cases are Alzheimer disease.
For these reasons , latent variables are often considered optimal for describing individual differences in cognitive abilities.
For these reasons , studying early retirement is highly relevant.
For these reasons , the therapeutic potential of carnosine supplementation has been tested in numerous diseases in which ischemic or oxidative stress are involved.
For these reasons , VDAC has become a potential therapeutic target to fight cancer but also other diseases in which mitochondrial metabolism is modified.
For these shifts , ARD affected the age groups differentially.
For these studies we will rely heavily on our models and those of others to reconcile some of the apparent inconsistencies in the literature.
For these valuation chronological age alone is not sufficient.
For the shared-housing arrangements ( SHA ) setting , we used baseline data from the WGQual Study.
For the short-term outcome , race / ethnicity and marital status showed a positive cumulative effect on the risk for readmission.
For the simpler task , no time differences due to attentional focus emerged.
For the SSR facial sides subjects followed two morning-evening regimens.
For the statistical analysis , the χ2 test was used ( p < 0.05 ) .
For the T2WI , there was no correlation with either the postnatal age or the gestational age at examination.
For the thermocycled and non-thermocycled groups , Ra ( µm ) was @number@.69±0.16 and @number@.12±0.52 , respectively.
For the timed get-up-and-go test of @number@ s , the sensitivity = @number@ and specificity = @number@
For the treating physician it is therefore important to diagnose CKD early to slow its progression.
For the treatment of mold infections , it is referred to the AWMF guidelines for diagnosis and treatment of invasive Aspergillus infections.
For the UEF test , each participant performed a 20-s elbow flexion , within which they repetitively and rapidly flexed and extended their dominant elbow.
For the United States alone , persons aged ≥65 years are projected to comprise over @percent@ of the population by the year @number@
For the univariate analysis , the preoperative factors for postoperative complications were gender , AG , and smoking ( P < @number@ ) .
For the VAN nodes ( TPJ and VFC ) , adults showed greater functional connectivity with regions within the network compared with children.
For the vast majority of evaluations , the strength of evidence between covariates and bleeding was low.
For the verbal task , the weight-bearing distribution produced was assessed with force plates.
For the visual stimulus , we used a constant-speed antero-posterior ( A-P ) stimulus BTT and a constant-speed lateral BTT.
For the WB technique , smaller reductions after @number@ year were observed without oxalate treatment for SB and after oxalate treatment for PBNT.
For the whole sample , older age and a high level of personal mastery were the most important predictors.
For the younger adults , there were no significant correlations between measures of EF and fine motor control.
For this analysis , baseline was defined as the 1991-1993 examination ( n = @number@ ) when men were aged 71-93 years old.
For this analysis , @number@ participants were studied.
For this analysis , we analyzed @number@ @number@ people with available BP data from VACS VC , who were free of cardiovascular disease at baseline.
For this analysis , we included @number@ participants with a creatinine clearance of at least @number@ mL / min.
For this approach , an understanding of the mechanisms of swallow initiation and identification of factors that facilitate or suppress swallow initiation are important.
For this DMTS task , a shape was displayed on the center one of three press-plates.
For this evolutionary reason , mitochondria have maintained their own genome.
For this , extra focus needs to be given to improving service and manpower development both during and after formal training.
For this , measurement invariance ( MI ) framework was used.
For this , @number@ participants aged between @number@ and @number@ were recruited.
For this purpose , a commercially available enzyme-linked immunosorbent assay ( ELISA ) test for all SFGR was used.
For this purpose atrophy markers have been explored and their effectiveness has been evaluated both cross-sectionally and longitudinally.
For this purpose , DCs were generated with the use of peripheral blood monocytes from healthy young and aged subjects.
For this purpose , GFR assessed with the GFR ( MAYO ) formula appears to better stratify NT-proBNP in older adult subjects.
For this purpose , mainly older participants were involved in user studies to continuously evaluate and support the development strictly following a user-centred design process.
For this purpose metabolomic blood test is available which is of non-targeted ( review ) nature.
For this purpose , muscle samples were divided into @number@ groups ( n = 8 ) .
For this purpose , @number@ elderly and @number@ young women were included in this study.
For this purpose , @number@ IVDs from @number@ adult patients with DDD and @number@ IVDs from @number@ adolescent patients with AIS were obtained at surgery.
For this purpose regional perfusion values obtained with ASL MR imaging were evaluated as a function of postmenstrual age.
For this purpose , serum samples were collected from @number@ local volunteers and @number@ Tibetan pigs from @date@ to @date@ .
For this purpose , we used data from in-depth interviews with @number@ residents across @number@ NORC programs in New York City.
For this purpose , women , rather than men , were studied to minimize the effect of smoking.
For this reason , a complete and global examination of patient characteristics is mandatory in the drug prescribing process.
For this reason , aging is a major concern worldwide.
For this reason , air filtration in hematooncology units has been recommended.
For this reason , an important focus of the study of centenarians is their relative resilience to age-related cognitive decline or dementia.
For this reason , a simple , reliable , and inexpensive method of early AD detection is urgently required.
For this reason , as supported by the most recent sociological literature and evidence from studies conducted in Italy and abroad ( cf.
For this reason , different preventative measures should be adopted to delay or reverse cognitive impairment among community-dwelling older men and women.
For this reason , functional telomeres are vital to genome stability.
For this reason , it serves as a model both of irreversible acute kidney injury and of events taking place during human chronic kidney disease.
For this reason , pharmacological research is now focused on the possible use of antiosteoporotic drugs to promote bone healing in frail patients.
For this reasons , the evaluation of the atopic condition also in the geriatric patient is recommended.
For this reason , surgery is often postponed until patients develop very late complications.
For this reason , the benefit of using whole-body cryotherapy in these persons is debatable.
For this reason , the causal link between size and composition of the social networks and satisfaction with life is yet to be explored.
For this reason , the evaluation of the atopic condition in the geriatric patient is recommended.
For this reason , theory , and theory-based evaluations are critical to health equity.
For this reason there has been a resurgent interest in investigating the role of inflammation during tissue repair and regeneration.
For this reason , treatment for osteoarthritis , the costliest condition in the elderly population , has drawn great scrutiny from insurers and the government.
For this reason we decided to compare the PTA values of individuals aged @number@ or older.
For this reason , we investigated right thoracic curvature in the normal spine.
For this reason within the German Society for Epidemiology we founded the working group ' Epidemiology of Ageing ' in @number@
For this , statistical analysis using linear mixed-effects ( LME ) models are used to account for correlated observations from individuals measured over time.
For this study , factorial validity of responses to this instrument is examined relative to a representative English Canadian sample of caregivers.
For this study , in each village , male and female older persons aged @number@ and over participated in the focus group discussions.
For this study , we asked : What is the experience of spousal caregivers to persons with multiple chronic conditions ?
For this study , we selected @number@ case children born small-for-gestational age ( SGA , birth weight < -2SDS ) and @number@ control children.
For this study we used an in vivo wrinkle-induced mouse model.
For this , subjective social risk ratings were used for a parametric modulation analysis on fMRI data from the social risk task.
For this systematic review , data extraction and quality assessment were performed by @number@ independent reviewers.
For this validation we stored encapsulated samples either at ambient temperature or at several elevated temperatures to accelerate aging.
For this , we first represent the brain functional network by a symmetric positive matrix computed using sparse inverse covariance estimation.
For those aged 60-69 , high personal mastery was the only independent predictor of a younger SAP.
For those aged 70-79 years , only health - good mental and physical health - independently predicted a younger SAP.
For those experiencing an outcome , we estimated effects of clinical features on the amount of the outcome.
For those in rural communities , it's even harder.
For those nursing older people in a variety of settings , knowledge of VTE prevention , diagnosis and treatment is essential.
For those patients who do not improve with conservative care , surgery is considered an appropriate treatment alternative.
For those receiving care , poorer function was associated with more caregiving.
For those residents who died during the study period , data were also collected within @number@ days of death.
For those studies with quantitative health outcomes , more than half ( @percent@ ) reported postintervention improvements in outcomes.
For those widowed for a longer period , the corresponding estimate was @number@ ( @percent@ CI @number@ @date@ ) .
For those with at-risk drinking or MALD , integrated stepped care starts with a one session brief intervention and follow-up 2-week telephone booster.
For those with AUD , integrated stepped care begins with APM.
For those with dementia , behavioral problems predicted caregiver emotional strain ( P < .001 ) and depressive symptoms ( P = .01 ) .
For those with lower HR reactivity , engaging frequently in MSA produced compensatory benefits for executive function.
For those with MCI alone , the only significant predictor of memory complaints was poor psychological well-being.
For those with medical expenditures , higher cognition and poorer function were associated with more spending.
For those with NH expenditures , no clinical feature predicted the amount.
For those with PU on Arginaid Water supplementation , plasma arginine concentration and PU status were monitored every month.
For those with surgical contraindications , SRS and observation are treatment alternatives.
For TML , percentages of gap-free margins dropped to 87-90% in enamel and to 58-66% in dentin ( p < 0.05 ) .
For tomography , sensitivity was @percent@ , specificity @percent@ , positive predictive value @percent@ and negative predictive value @percent@.
For total protein expression , principal component analysis revealed a large overlap between changes with overall aging and between APOE genotypes.
For training and evaluation independent of age and gender , a subset of @number@ cases and @number@ matched controls was selected.
For trials reporting at least one death ( n = @number@ ) , a summary estimate was calculated using the Mantel-Haenszel method.
Fortschr Röntgenstr @number@ 190 : @number@ - @number@
Fortunately , as noted in the geriatric literature , cognitive training strategies have been shown to improve targeted neurocognitive domains and everyday functioning.
Fortunately , basic and translational studies have been pivotal in providing us with a mechanistic understanding of the cellular and molecular pathophysiology of this condition.
Fortunately both OA symptoms and obesity can be ameliorated through lifestyle modifications.
Fortunately , cells contain a hierarchical system of pathways coping protein damage.
Fortunately , in parallel our understanding of this malady has also grown substantially in recent years.
Fortunately , neuroinflammation also provides an opportunity for therapeutic interventions.
Fortunately , the cell's DNA synthesis apparatus can bypass certain DNA obstructions , but the mechanism ( s ) are still poorly understood.
Fortunately , the faces at close ages look quite similar since aging is a slow and smooth process.
Fortunately , the majority of the respondents ( @number@ % ) found their existing financial schemes helpful in reducing the necessary out-of-pocket expenses.
Fortunately , these chronic insulin-related conditions are amenable to pharmacological intervention.
Fortunately , the strain of HPV infecting these women is not associated with cervical cancer.
Fortunately , we succeeded in identifying human skin fibroblast-derived elastase as a previously known enzyme , neprilysin or neutral endopeptidase ( NEP ) .
For two patients showing no spontaneous follicle growth , human menopausal gonadotropin treatment induced follicle growth at 6-8 months after grafting.
For two trials CGA was done pre-operatively and postoperatively for the remaining.
Forty assisted-living older adults ( @number@ males ) aged @number@ ± @number@ years participated in the study.
Forty community-dwelling older adults were categorized based on Montreal Cognitive Assessment ( MoCA ) performance.
Forty community providers were trained and then performed community screenings.
Forty-eight aMCI patients who underwent Pittsburgh compound B ( PiB ) positron emission tomography were recruited.
Forty-eight community-dwelling elderly were randomized into true or placebo acupuncture , and intervention consisted of ten sessions.
Forty-eight HetAT and @number@ non-HetAT individuals had cancer , among them @number@ HetAT and @number@ non-HetAT were diagnosed after blood sample collection.
Forty-eight of @number@ nonagenarians ( @percent@ ) with combined impairment died during the same follow-up period.
Forty-eight patient samples ( @number@ young , @number@ aged , and @number@ with AD ) underwent histological analysis.
Forty-eight percent had prior dementia.
Forty-eight percent of the variance in rise time ( p < @number@ ) was attributed to TUG velocity.
Forty-eight percent presented with hemorrhage.
Forty-eight samples were produced by adding different amounts of ZnO into a commercial maxillofacial silicone ( EPISIL-E ) .
Forty-eight subjects ( @percent@ ) demonstrated an initial roll with asymmetrical squat sequence when rising to stand.
Forty-eight subjects were recruited who had moderate to deep wrinkles , according to the Modified Fitzpatrick Wrinkle Scale ( MFWS ) .
Forty eight three syllable words were selected , being @number@ real words and @number@ that were manipulated in order to obtain non-words.
Forty-eight three-unit FPDs were adhesively bonded ( AB ) or conventionally cemented ( CC ) .
Forty-eight well functioning older adults ( @number@.5±5.3years old ; @number@ men , @number@ women ) were included in this study.
Forty-eight women and @number@ men , aged 55-74 years and living in upper Hudson River communities completed a questionnaire and provided blood specimens.
Forty elderly participants completed a STR task under four different conditions which were thought to differentially involve LTM representations.
Forty female subjects were randomly divided into two groups : BoNTA group and control group.
Forty-five drivers also agreed to undergo further testing at our lab.
Forty-five healthy subjects recruited on the basis of tri-allelic 5-HTTLPR genotype , with inferred high or low 5-HTT-expression , were included in a double-blind study.
Forty-five herniated IVDs were harvested and immunostained to determine the distribution and type of ADAMTS-5 expressing cells.
Forty-five ( @number@ ) subjects stood on a compliant surface with their eyes closed and were instructed to maintain a stable upright stance.
Forty-five percent of retired senior surgeons performed within the range of the younger surgeons on all tasks.
Forty-five skin samples were excised from the anterior thoracic region of cadavers of caucasian origin in the age range 33-82 years.
Forty-five subjects with symptomatic non-inflammatory Achilles enthesopathy were compared to @number@ asymptomatic controls.
Forty-four percent focused on components of comprehensive care and @percent@ on active involvement of older adults.
Forty-four percent of dementia caregivers exhibited depressive symptoms , compared with @percent@ of CIND caregivers ( P = .03 ) .
Forty-four percent of the sample met criteria for neuropathological diagnosis.
Forty-four premenopausal women with leiomyoma were recruited for another study , and @number@ of those women were treated with a GnRH agonist.
Forty-four relevant articles were included , involving a total of @number@ subjects.
Forty-four studies met eligibility criteria ( N = 2122 BD participants ) .
Forty-four women were scanned using a computerized ultrasonic scanner developed in our laboratory.
Forty individual semi-structured interviews were conducted , tape-recorded , and transcribed verbatim.
Forty mice were classified into four groups according to age and degree of hearing loss.
Forty million inpatient surgical procedures were performed in the United States in @number@ followed closely by @number@ million outpatient surgeries.
Forty-nine healthy young ( mean @number@ years ) and @number@ elderly ( mean @number@ years ) individuals were included.
Forty-nine percent of older adults had two or more cardiometabolic risk factors ; @percent@ had three or more.
Forty-nine percent of patients had not received any AVK treatment before admission.
Forty-nine shoulders ( @percent@ ) exhibited scapular notching.
Forty-nine subjects ( mean age @number@ years [ SD : @number@ ] , @number@ females [ @percent@ ] ) completed the study without adverse effects.
Forty-nine video segments were extracted to create @number@ clips each of @number@ min.
Forty-one baseline predictors were assessed using a tree-based regression method ( Random forest ) to rank the relative importance of risk factors.
Forty-one IRB members representing five committees in Botswana participated in discussions groups in @date@ .
Forty-one lumbar disk patients were evaluated imaging for degenerative changes and their disk specimens immunohistochemical expression of MMP-1 and TIMP-1.
Forty-one of these patients also had shoulder radiographs.
Forty-one percent of procedures were for lead malfunction.
Forty-one percent of the GP group received a score of less than @number@
Forty owner-cat dyads were visited in their homes , on four occasions , during which their behaviours and interactions were video-taped.
Forty participants aged @number@ years and over trialled the NANA toolkit in their homes for three 7-day periods at four-week intervals.
Forty patients had an XI score of @number@ or less ( Group @number@ ) and between @number@ and @number@ ( Group @number@ ) .
Forty patients , @number@ women and @number@ men with a mean age ± standard deviation of @number@ ± @number@ years , underwent MIS for FDH.
Forty patients ( @percent@ ) had previously been treated with one or more chemotherapeutic regimens.
Forty patients scored ≥5 , which corresponded to being frail.
Forty patients were randomized for minoxidil on the eyebrow on one side of the face and placebo on the other.
Forty percent of the respondents demonstrated adequate knowledge of stroke.
Forty predictors of higher involvement were studied.
Forty-seven complications ( @percent@ ) were recorded , with @number@ cases ( @percent@ ) occurring after @number@ years.
Forty-seven ( @number@ percent ) legs had critical limb ischemia , and @number@ ( @number@ percent ) had at least two-vessel distal runoff.
Forty-seven older drivers completed an on-road evaluation where directions were provided by an in-vehicle GPS navigation system and their behaviour was recorded using video technology.
Forty-seven percent of participants identified themselves as Black / African American , and @percent@ as White / Caucasian.
Forty-seven right-handed subjects participated : @number@ young ( @number@ ± @number@ years ) and @number@ old ( @number@ ± @number@ years ) .
Forty-seven volunteers were interviewed for recruitment into the study.
Forty-seven women aged 18-34 took part in the intervention : @number@ women in individual sessions , and @number@ in four focus groups.
Forty-six healthy older adults ( @number@.0±7.5 years ) and @number@ healthy young adults ( @number@.1±2.3 years ) participated.
Forty-six ( @number@ % ) HIV-positive subjects were reactive for HBsAg and positive for HBV-DNA.
Forty- six % of participants had 25OHD levels ≥20 ng / ml.
Forty-six older adults ( age 45-68 ) and @number@ younger adults ( age 18-25 ) met criteria for BPD.
Forty-six participants enrolled and completed questionnaires.
Forty-six volunteers were tested ranging in age from @number@ to @number@ years.
Forty-six women aged 40-80 years old participated in either the MBE program or maintained normal daily activity.
Forty subjects required a second retreatment for optimum NLF correction.
Forty subjects who also had OP comprised Group I and the remaining @number@ OA subjects comprised Group II.
Forty subjects who did not meet both of these criteria comprised the stable group , and the remaining @number@ subjects comprised the unstable group.
Forty-three inpatients agreed to participate in the @number@ survey and @number@ in the @number@ survey.
Forty-three newspaper articles dealing with hope and cancer were collected and analyzed to explore how hope is socially constructed by print media.
Forty-three of @number@ patients ( @percent@ ) received analgesics.
Forty-three rare polymorphisms were detected in this cohort.
Forty-two amnestic mild cognitive impairment patients were consecutively recruited.
Forty-two articles met the inclusion criteria for quantitative evaluation.
Forty two full text papers were checked for inclusion and thirty six studies were finally included in this review.
Forty-two patients became pregnant ( @percent@ ) .
Forty-two patients younger than @number@ years of age had @number@ seizures and nine patients older than @number@ years had @number@ seizures.
Forty-two percent had HIV-associated neurocognitive disorder , and all were receiving highly active antiretroviral therapy.
Forty-two per cent of those≥60 years of age vs. 20% < 60 years of age experienced amnesia post-induced syncope ( P = 0.003 ) .
Forty-two scales were evaluated for their test-retest or interrater reliability.
Forty-two subjects participated in each experiment : @number@ young adults and @number@ older adults.
Forty variants were observed : @number@ were rare ( minor allele frequency < 2% ) ; @number@ were nonsynonymous.
Forty years after the war ended , war veterans still seek out VA or Vet Center counselors to assist with traumatic stress symptoms.
Forty young-old and @number@ old-old adults took part in the study.
Forty young participants learned a route through a virtual environment before either resting wakefully or engaging in an unrelated perceptual task for @number@ min.
For UGT1A6 , activity matured at @number@ months ( @number@ nmol · min · ( @number@ ) mg protein ( @number@ ) ) .
For unipolar depression only elderly with a current episode shows association with suicide risk.
For unpartnered participants , greater life satisfaction and was associated with more physical tenderness.
For various therapeutic approaches , such as bone and cartilage repair , MSCs are expected to replace the damaged tissues by direct differentiation.
For vitamin D and iron , @percent@ and @percent@ , respectively , had intakes below the Lower intake level.
For voxelwise analysis , two-sample t-test for group comparison between HC and PD was computed in both image modalities.
For walking speed , the sensitivity and specificity were @percent@ and @percent@ in men and @percent@ and @percent@ in women respectively.
Forward- and backward-digit span tests were also conducted to measure the participants ' working memory.
Forward and backward translation procedures were used to obtain semantic equivalence of the original English version of the RS.
Forward loss of balance was achieved by releasing participants from a static forward lean angle.
Forward loss of balance was achieved by releasing participants from a static forward lean angle.
Forward loss of balance was induced by releasing participants ( n = 117 community-dwelling older adults ) from a static forward lean angle.
For ward patients , a β-lactam with a macrolide or a respiratory fluoroquinolone alone should be given to cover typical and atypical pathogens.
Forward planning is essential to put systems in place that can deal with the increasing demand.
Forward reaching is an integral part of many essential daily activities.
Forward serial clustering was also negatively correlated with age.
Forward stepwise logistic regression was used to determine associations of baseline CKD and functional decline.
FoR was assessed using the short form of the Fear of Progression Questionnaire.
For women aged 57-74 , however , behavioral risk factors explain @percent@ of the relationship between race and CRP.
For women aged @number@ years , the OG-led service was the most cost-effective at £22 , 709 / QALY.
For women , a negative association between the T2 value of bone marrow water and PDFF was found.
For women close to an intervention cut-off reclassification , rates ranged from @percent@ to @percent@ and were < 1% otherwise.
For women diagnosed with osteoporosis , some form of pharmacologic therapy should be initiated.
For women , ever drinking alcohol in the past year was associated with a decreased risk of having tinnitus ( OR = @number@ ) .
For women , in addition to age , social support and marital status were significantly related.
For women , mean salt intake decreased @number@ g / year among 70- to 79-year-olds ( P = @number@ ) .
For women only , an early transition to parenthood partially explained the association between childhood disadvantage and onset of heart problems.
For women , stunting was associated with a lower age at first birth and higher number of pregnancies and children.
For women , the adjusted IQ difference was @number@ points , and for men it was @number@ points.
For women , the most common cancer was breast cancer ( @number@ million cases ) .
For women , there was evidence of maintained well-being and identification over time.
For women , the risk factors were lower level of educational and lack of religious attendance.
For words , older participants performed worse than young participants on item and associative tests but to a greater extent on the latter.
For WPM , having a partner for social support was not associated with naming a health-care proxy.
For wrinkles , the experimental group had better results on weeks @number@ @number@ @number@ @number@ and @number@
For Y cells , reduced collagen synthesis was observed at @number@ h.
For years our efforts have been focused on vaccination during childhood.
For years , telomeres were assumed to be transcriptionally silent , because of their heterochromatic state.
For young adults there was no significant difference between these conditions.
For younger adults , conversations with same-age acquaintances were most enjoyable and conversations with children and older adults were least enjoyable.
For younger adults , however , this pattern was reversed.
For younger adults , this marker correlated with the effect of both gain and loss incentives on performance.
For young learners , memory was superior in the honor condition , but older learners actually revealed numerically higher performance in the dishonor condition.
For young subjects , the mean muscle / bone ratios were @number@ and @number@ for men and women , respectively.
For youthful eyebrows , attenuation of the depressor muscle may restore the muscle balance in treatments for eyebrow rejuvenation.
For youth , probable positive evidence emerged for ' previous PA ' and ' independent mobility and active transport ' among children and adolescents.
Fossil evidence for longitudinal arches in the foot is frequently used to constrain the origins of terrestrial bipedality in human ancestors.
Fostering of interest in rural may help to address nursing workforce shortages in rural settings.
Found that people with accelerated aging of the respiratory system decreased pulmonary gas exchange response to breathing resistance expiration.
Four age groups ( 7th to 10th decades ) were evaluated.
Four ARC classes were identified.
Four articles examined the relation of PA with general SS , @number@ with SS specific to PA ( SSPA ) , and six with loneliness.
Four articles on the biological properties of this new @number@ mg / ml HA dermal filler were suitable for inclusion in this review.
Four categories emerged : valuing aging nurse faculty , enduring environmental challenges , recognizing stakeholder incongruence , and readjusting.
Four categories of change in activity engagement were considered : subjects who remained active ; remained inactive ; became inactive and became active.
Four children younger than @number@ years presented with a short symptom interval , vomiting , and Parinaud's syndrome.
Four clusters of informativeness were found but no socio-demographic features appeared significant.
Four coexpression modules were identified as potentially causal based on genetic inference because expression-related SNPs for their corresponding genes demonstrated enrichment for BP GWAS signals.
Four cognitive domains were evaluated using z scores of memory , language , executive function , and visuospatial reasoning.
Four cognitive stages were studied : cognitively healthy individuals , mild cognitive impaired patients , mild dementia patients and advanced dementia patients.
Four compounds have been isolated and purified by rigorous column chromatography.
Four compounds ( valinomycin , , deltamethrin , and triphenyl phosphate ) were cytotoxic in all four cell types.
Four controls were matched to each case by sex , age and place of residence.
Four-day ATRA treatment increases β-secretase @number@ ( BACE1 ) level , Aβ1-42 production , and receptor for advanced glycation end-products ( RAGE ) expression.
Four-degree vergence responses were modified using a double-step protocol.
Four designs were tested : lingual , mesiolingual , buccal , and inlay retainers.
Four dimensions of psychosocial mediators were assessed : control expectancy , self-efficacy , social influence , and social support.
Four diseases not strongly linked to mortality ( arthritis , cataract , osteoporosis , glaucoma ) were significantly more common for LLFS probands.
Four DNA extraction methods were also compared using produce enrichment broths.
Four drugs are used : latanoprost , timolol , brimonidine and dorzolamide.
Four elements are identified as indicators.
Four experimental groups were used : Control-wild , Al-wild , Control-Tg , and Al-Tg mice.
Four factors accounted for @percent@ of the variance for temperament subscale.
Four FBB- developed non-AD dementia.
Four-field stereo retinal color photography was done , and diabetic retinopathy ( DR ) was classified according to the Early Treatment DR Study grading system.
Four-fifths of the interviewed patients ( @percent@ ) were not afraid of death.
Four focus group discussions and @number@ individual interviews were undertaken.
Four focus group interviews were conducted between April and June of @number@ at community halls in Fujisawa City.
Four focus groups were conducted with @number@ older adult clients and volunteers at a national LGBT social service and advocacy organization.
Four formulations of AL were investigated.
Four further databases were searched for systematic reviews and guidance from @number@ to @number@
Four genes were identified within the top @number@ associations with airway responsiveness.
Four groups of @number@ were formed with mean ages of @number@ @number@ @number@ and @number@ years.
Four healthy behaviors were measured : not smoking , moderate alcohol consumption , regular exercise , and sleeping @number@ to @number@ hours per day.
Four homoplasmic and six heteroplasmic alterations were found to be novel.
Four hundred age- and sex-matched controls were enrolled for comparison.
Four hundred and eighty postmenopausal women representing Bengali-speaking Hindu ethnic group of West Bengal , India were interviewed about their attitude toward menopause and aging.
Four hundred and seventy ( @percent@ ) of the submissions mentioned homebirth.
Four hundred and seventy-seven men had body weight measured during the last @number@ years prior to death.
Four hundred and twelve elderly participants who completed evaluations of cognitive function and metabolic parameters in 2005-2006 and 2010-2011 were analysed.
Four hundred Danish emerging adults ages 17-29 were surveyed regarding their conceptions of adulthood and their self-assessments of their adult status.
Four hundred older adults responded at @number@ time points , @number@ months apart.
Four hundred reports were randomly selected and manually reviewed for acute fractures to establish a gold standard.
Four hundred seventeen patients had had a CSF shunt for the treatment of hydrocephalus and thus are included in this analysis.
Four hundred twenty-five teeth from @number@ subjects were analyzed.
Four hundred two adults in South Korea responded to survey questions designed to capture the above constructs.
Fourier Fractal dimension is computed on these preprocessed images and does not require any segmentation of the vessels.
Fourier velocity encoded M-mode allowed to measure global and regional PWV in the descending aorta.
Four implants were done in aortic , one in mitral , and one in tricuspid position.
Four IMUs were attached to the subjects , one on each thigh and shank.
Four individual items : weight loss , decrease in food intake , recent stress and BMI were independent predictors of mortality.
Four large clinical Phase III trials demonstrated efficacy of ATX-101 in reduction of SMF measured by validated scales and objective measurements.
Four latent groups were extracted based on three assessments for the components of MetS , together with their transition patterns.
Four levels of evidence were used when evaluating the literature : good , moderate , tentative , and none.
Four levels of severity were identified for neck pain with and without arm pain , each with their own disability weights.
Four long-term care institutions with different types and sizes located near Fong-Yuan Hospital in downtown Fong-Yuan were investigated.
Four LSA variables were obtained according to the maximum life space achieved and the level of independence.
Four main genes ( CONCLUSIONS : There is a lack of consensus among clinicians as to the definition of FALS.
Four main longevity indicators were calculated.
Four major themes impacting device use / disuse were identified : knowledge gaps , relationships with health care providers , environment , and personal experience.
Four major themes were identified.
Four members of the PAX family , PAX2 , PAX4 , PAX6 and PAX8 are known to be expressed in the pancreas.
Four metabolites associated with an increased risk of PD were identified , including S-methylcysteine , linolenic acid , eicosapentaenoic acid , and linoleic acid.
Four months after the onset , she entered a state of an akinetic mutism.
Four mutations in the CISD2 gene have been reported.
Four new biospecimens yielded @number@ novel measures.
Fournier gangrene ( FG ) is an infectious condition with fulminant evolution and is sometimes life-threatening.
Four notional groups were created , depending on the level of interest at entry and at exit.
Four of @number@ ( @number@ % ) levodopa-naïve PD patients were diagnosed with neuropathy.
Four of the loci were also associated with adult human stature , but these remained associated with intracranial volume after adjusting for height.
Four of them are non-chemotherapeutic and generally well tolerated.
Four older and @number@ younger participants met the definition of frailty.
Four open-ended questions were included at the end of the survey , relating to means of promoting career longevity.
Four or more conditions were prevalent in @percent@ and associated with age , severe / profound ID and Down syndrome.
Four out of these five loci were confirmed in independent replication samples.
Four partially concordant symptom clusters emerged in both groups ( i.e. , mood / cognitive , malaise , body image , and genitourinary ) .
Four patient had insulin dependant diabetes while ten of them had diabetes regulated with oral antidiabetics.
Four patients came to autopsy.
Four patients died ( @percent@ ) .
Four patients discontinued F6H8 and @number@ patient did not present for follow-up.
Four patients exhibited pretherapy seizures and no patients experienced recurrent or new-onset seizures.
Four patients had esophageal ulcers in the BD group but no case in controls.
Four patients had long-term hemodialysis.
Four patients received early immunosuppressive treatment in terms of corticosteroids , only slight relief of neurological symptoms was seen in @number@ patients.
Four patients underwent autopsy-pathological lesions revealed striking similarity to sporadic Creutzfeldt-Jakob disease but also involvement of the white matter.
Four patients with a mismatch had an acute infarction in more than one coronary artery territory on CMR.
Four patients with probable DLB had normal imaging.
Four percent of centenarians die from cancer.
Four percent of residents voted ( national turnout : @percent@ ) , by proxy ( @percent@ ) or at polling places ( @percent@ ) .
Four percent were frail.
Four potential gene-environment interactions were identified as noteworthy ( BFDP < @number@ ) when assuming a true prior interaction probability of @number@
Four processes are identified , which illustrate how access to financial and social resources may lead to opportunities and constraints in experiences of care.
Four randomized or matched trials reduced delirium incidence by @percent@ ( OR , @number@ @percent@ CI , @number@.42-0.76 ) .
Four raters scored each event using the traditional definition and , two weeks later , using the new definition.
Four relatively unexplored compounds also scored well with rapamycin.
Four reviewers screened the titles , abstracts , and full texts of the articles for inclusion.
Four rounds of screening of articles in these databases resulted in a final sample of @number@ articles.
Four significant associations with the proposed method were found.
Four single-nucleotide polymorphisms ( rs1207568 , rs564481 , rs9527025 , and rs9536314 ) of the klotho gene were genotyped using the ABI SNaPshot method.
Four single nucleotide polymorphisms ( SNPs ) in the VDR gene , Bsm1 , Taq1 , Apa1 , and Fok1 , were genotyped.
Four southern African medicinal plants ; Clerodendrum glabrum , Schotia brachypetala , Psychotria capensis and Peltophorum africanum , were investigated to assess their anti-aging properties.
Four studies showed a significant effect on muscle strength , while this effect was not observed in three others studies.
Four studies were graded low risk of bias and recruited a representative patient sample.
Four tag Single nucleotide polymorphisms ( SNPs ) in regions of interest were genotyped.
Fourteen children active in sports participated in a laboratory biomechanical evaluation.
Fourteen cognitively normal elderly subjects were also selected from a pool of elderly volunteers.
Fourteen cohort studies participate in CHANCES with @number@ elderly ( and @number@ deaths ) , from @number@ European and three non-European countries.
Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups.
Fourteen healthy volunteers ( mean age @number@ years ) participated in this study after providing written informed consent.
Fourteen healthy young men performed four to six constant-power-output trials on a cycle ergometer to the limit of tolerance.
Fourteen hospital-based observational studies exploring ADRs in the elderly in the acute care setting were eligible for inclusion in this review.
Fourteen hundred and thirty-six respondents provided olfaction data in both waves.
Fourteen in-depth interviews were conducted with Filipino health care aides and long-term-care policy stakeholders in Winnipeg , Manitoba.
Fourteen of @number@ specific cancer sites showed a reduction in risk associated with increased adherence.
Fourteen of them received the closure of broken ends of pancreatic head , pancreaticojejunostomy ( mono-anastomosis ) and the rest one received dipl-anastomosis.
Fourteen of the @number@ questionnaire items were not answered by more than @percent@ of the participants.
Fourteen old ( 59-73 yrs ) and fourteen young ( 22-31 yrs ) males walked on a walkway which included one covered element.
Fourteen out of the sixteen included articles did not use an existing technology acceptance framework or model.
Fourteen participants ( 63-74 years ) searched for a target item ( coloured , oriented rectangular bar ) among a display set of distractors.
Fourteen participants ( HC = @number@ MCI = @number@ ) underwent one imaging modality.
Fourteen participants representing nine community and health service organisations located in the Melbourne metropolitan area took part in semi-structured interviews.
Fourteen patients developed seizures during that period and @number@ did not.
Fourteen patients with mild AD , @number@ healthy older participants ( NC ) , and @number@ younger adults ( YA ) performed two tasks.
Fourteen peer-reviewed articles were selected for this review.
Fourteen percent reported arthritis , and @percent@ had vitamin D insufficiency.
Fourteen studies mostly controlled one confounder ( one controlled comorbidities ) , and limited control of confounders limits accuracy.
Fourteen young lean and @number@ older obese subjects completed an 8-week Bikram yoga intervention in which classes were completed @number@ times per week.
Fourteen young men ( age : @number@.4±1.0years ) and @number@ elderly men ( age : @number@.8±5.9years ) performed the stair ascent and descent.
Fourth Age adults ( age 80 + ) reported greater reductions in AI than Third Age adults ( age 64-79 ) .
Four themes from the research ( physical challenges , a magnitude of loss , internal changes , & stigma ) are discussed.
Fourth , EM was affected by higher PP but differentially less so for carriers of the ApoE ε2 allele than the ε3 or ε4 alleles.
Fourth , policy briefs were developed and presented to the Ghana Health Services.
Fourth , potentially atheroprotective LXR-dependent SREBP1c signaling was normal in TT1 , but was rather suppressed in TT2 cells.
Fourth , the anterior tip of the MFS predicts the location of a face-selective region , mFus-faces / FFA-2.
Fourth , the definition by van der Klink et al ( @number@ ) suggests that SE only applies to individuals who are employed.
Fourth , the more components needed to assemble into a complex to drive targeted retrotransposition , the less likely the strategy will increase targeted insertions.
Fourth , we found that introspection processes were related to age differences in decisions.
Fourth , we observed similar longitudinal change patterns for IM and ISD.
Fourth , what are the emergent patterns of functionally adapted trait sets in corticocancellous structures ?
Four trajectories of social activity were identified and used as predictors of late-life disability.
Four types of circulating IGFBP complexes were examined in this study by immuno- and ligand-binding assays in adults of different age.
Four types of interventions were tested in the @number@ research reports.
Four variants were observed in non-coding regions.
Four-week-old male Wistar rats were fed a modified AIN-93 diet containing @percent@ casein as the reference group or CH as the treatment group.
Four weeks after introduction of the customized GE diet , there was distinct clustering of GE-fed mice as compared to the control-fed group.
Four weeks following the first completion , another KAOP form was given.
Four WM regions of interests ( WM-ROI ) , relevant to the study of aging and neuroinflammatory diseases , were examined.
Four years of annual radiographic and clinical assessments from the Osteoarthritis Initiative were analyzed.
FOXM1 activity correlated with expression of the enzyme Pin1 , which we found to be indicative of a poor prognosis.
FOXO1 acetylation inhibited its transcriptional activity on target genes , that is , SIRT1 and the ROS scavengers , catalase and manganese superoxide dismutase.
FoxO1 and FoxO3 are key factors of muscle energy homeostasis through the control of glycolytic and lipolytic flux , and mitochondrial metabolism.
FOXO1 and FOXO3 phosphorylation was increased by IL-1β , PDGF , bFGF , IGF-1 , and the oxidant t-BHP.
FOXO1 and FOXO3 were more strongly expressed the superficial and mid zone as compared to the deep zone and were mainly localized in nuclei.
FoxO1 entered into the field of skeletal biology by a property that is unique among its functions in other organs.
FoxO1 mRNA was higher in patients , whereas FoxO3 , atrogin1 and myostatin mRNAs and MuRF1 protein were lower compared with controls.
FOXO3a also displayed strong purifying selection.
FOXO factors are therefore bona fide tumor suppressors , and their potential use as therapeutic targets in cancer has been a matter of debate.
FoxO metabolic functions are relevant to glucose metabolism , tumor suppression , hematopoiesis , angiogenesis , and antioxidant defense.
FoxO proteins have also been implicated in the regulation of the cell cycle , apoptosis , and muscle regeneration.
FOXO transcription factors control proliferation , apoptosis , differentiation and metabolic processes.
FOXO transcription factors have emerged as rheostats that coordinate the activities of Akt and targets of rapamycin complexes ( TORCs ) .
FoxO transcription factors mediate anti-proliferative and pro-apoptotic signals and act as tumor suppressors in cancer.
FoxO transcription factors ( TFs ) extend lifespan in invertebrates and may participate in the control of human longevity.
FOX proteins have undergone diversification in terms of their sequence , regulation and function.
FPA diameter , wall thickness , circumferential , and longitudinal opening angles increased with age , while longitudinal pre-stretch decreased.
FPA is an uncommon complication , but a very significant one , that can have serious consequences.
FP conversion was defined as the onset of FP over two consecutive study visits.
FPG did not modify or mediate these associations.
FPG-sensitive sites , total antioxidant capacity and lipid peroxidation ( MDA ) were not statistically different between groups.
FP has been demonstrated in early case reports and case series to produce significant improvement in hypopigmentation of acne and surgical scars.
FPP caused a normalization of redox markers ( p < 0.01 vs. placebo ) .
FPP modulated the H₂O₂-induced ERK , Akt and p38 activation with the reduction of p38 phosphorylation induced by H₂O₂.
FPP supplementation brought about a significant reduction of Trx with levels comparable to the ones of healthy controls.
Fractal analysis has been used to determine the authenticity of major works of art.
Fractional ablative CO2 laser remains an excellent alternative to traditional blepharoplasty.
Fractional anisotropy ( FA ) , axial diffusivity , and radial diffusivity ( RD ) represented microstructural properties of normal-appearing WM within @number@ regions.
Fractional anisotropy ( FA ) is the most commonly used parameter as it is the best estimate of fibre integrity.
Fractional anisotropy is the most important parameter.
Fractional brain flow was also inversely correlated with cerebral white matter lesion grade , although this effect was not significant when adjusted for age.
Fractional calcium absorption was measured using a triple stable calcium isotope method based on isotope recovery in a 28-h urine collection.
Fractional filling every 3-4 months is continued until the desired level of volume correction is attained.
Fractional laser is effective on skin wrinkles and textural irregularities , but can induce postinflammatory hyperpigmentation ( PIH ) , especially in Asians.
Fractional laser technologies-first nonablative and more recently ablative-represent the most recent attempt to match the results seen in fully ablative procedures with less patient downtime.
Fractional non-ablative laser is a method which , in comparison to other methods , has the greatest impact on skin viscoelasticity.
Fractional photothermolysis has been reported in the literature to improve both the pigmentary and textural changes associated with photoaging.
Fractionated irradiation also reduces neurogenesis.
Fractographic analysis revealed that both fused and luted specimens had cohesive and adhesive fracture patterns which resulted in partial delamination of the veneer.
Fracture data were collected at 4-monthly phone calls and verified radiographically.
Fracture displacement in the elderly , however , does not necessarily result in functional impairment.
Fractured specimens were analyzed using scanning electron microscopy ( SEM ) .
Fracture liaison services ( FLSs ) with varying models of care are in place to take responsibility for this investigative and treatment process.
Fracture prevention with the use of hip protectors is effective in nursing facility dwellers , but not in elderly people living at home.
Fracture probability was analyzed by maximum likelihood attribution of individual measurements to @number@ or @number@ Weibull distributions , each with @number@ free parameters.
Fracture repair progresses through different pathways , striking a balance between bone formation and bone remodeling mechanisms.
Fracture resistances were determined for all the samples that survived aging.
Fracture resistance was determined after aging.
Fractures are more common in women than in men and , apart from the menopause , the reasons for this difference remain poorly understood.
Fractures occurring after the baseline visit were validated.
Fractures of the anterior pelvic ring also need special attention.
Fractures of the proximal femur are the most devastating outcome of osteoporosis.
Fractures of the pubic body and instabilities of the pubic symphysis need bridging plate osteosynthesis.
Fractures to the shoulder girdle are common injuries in an aging population.
Fractures were analyzed.
Fragile sites are conserved loci predisposed to form breaks in metaphase chromosomes.
Fragile X syndrome ( FXS ) is the most common monogenic form of autism spectrum disorder ( ASD ) .
Fragile X syndrome is caused by CGG trinucleotide repeat expansion within the fragile X mental retardation @number@ gene , when repeat number exceeds @number@
Fragility fracture can lead to long lasting painful and disabling condition.
Fragility fractures and their care are a major burden on individuals , health systems , and social care systems in industrialized countries.
Fragility fractures are associated with substantial pain and suffering , disability and even death for affected patients and substantial costs to society.
Fragility fractures are associated with substantial pain and suffering , disability and even death for the affected patients and substantial costs to society.
Fragility fractures commonly involve metaphyses.
Fragility fractures of the pelvis are the consequence of a low-energy trauma which occurs in a patient with an important decrease of bone mineral density.
Fragmentation ( fission ) of mitochondria , occurring in response to oxidative challenge , leads to heterogeneity in the mitochondrial population.
Fragmentation is seen to cause differences in benefit levels even within a single city.
Fragments of skin have been collected from subjects of both sexes and of different ages , totaling @number@ samples from different body regions.
Fragments of skin were removed before and @number@ months after each treatment and analyzed by optical and electron microscopy.
Frail and vulnerable patients , who are a minority of geriatric patients , should be included whenever it is relevant.
Frail CCS were more likely than nonfrail survivors to have a chronic condition ( @percent@ @date@ @percent@ ) .
Frail elderly exhibited poor sleep quality , when compared with non-frail individuals ( P = @number@ ) .
Frail elderly people are at risk for fall accidents due to intrinsic and extrinsic factors.
Frail elderly people were not represented in NOAC-investigating trials because of various exclusion criteria , and only one-third of patients were aged > 75 years.
Frail elders account for the highest health care costs in industrialized nations.
Frail health and poor physical functioning are prevalent among HR NBL survivors and suggest premature aging.
Frail individuals noncomorbid or nondisable were @percent@ and @percent@ , respectively , confirming an overlap but not concordance in the co-occurrence among these conditions.
Frail older adults are increasingly encouraged to be in control of their health care , in Western societies.
Frail participants had lower baseline DASI , SF-12 PCS , SF-12 MCS , physical well-being , and quality of life scores than non-frail participants.
Frail patients were markedly more likely to have gait speeds < 0.8 m / s ( OR @number@ @percent@ CI @number@.79-33.3 ) .
Frail subjects were considered when they had at least two conditions.
Frailty accompanies many age-related diseases but can also occur without overt evidence of end-organ disease.
Frailty according to FI-32 significantly predicted self-rated health and IADL dependency beyond the effect of age and gender.
Frailty , a clinical syndrome characterized by multisystem dysregulation and increased vulnerability to stressors , occurs prematurely in HIV-infected persons especially those with advanced disease.
Frailty , a clinical syndrome that typically occurs in older adults , implies a reduced ability to tolerate biological stressors.
Frailty and comorbidity were the most important factors associated with the use of hospital healthcare resources.
Frailty and depressive symptoms are common issues facing older adults and may be associated.
Frailty and its management represent an emerging area of clinical care in older adults.
Frailty and psychosocial resources were assessed at T1 ( 2005 / 2006 ) .
Frailty and sarcopenia are important concepts in the quest to prevent physical dependence , as geriatrics are shifting towards identifications of early stages of disability.
Frailty appears to be secondary to multiple conditions using multiple pathways leading to a vulnerability to a stressor.
Frailty , a state of increased risk due to accelerated deficit accumulation , is robustly a risk factor for cognitive impairment.
Frailty categories ( robust , pre-frail , and frail ) were based on @number@ baseline illness and function items.
Frailty classification also showed a very wide range of agreement ( Cohen's κ = @number@ @date@ ) .
Frailty contributes valuable prognostic insights incremental to existing risk models and assists clinicians in defining optimal care pathways for their patients.
Frailty could be considered in the development of dosing guidelines for drugs that undergo significant excretion through glomerular filtration.
Frailty definitions , gait protocols and parameters were inconsistent , which made comparison of outcomes difficult.
Frailty development was related only in men with testosterone levels at the beginning of the study ( p = @number@ ) .
Frailty , geriatric conditions , cardiovascular diseases and WBC count have also been associated with low grade inflammation.
Frailty has become one of the ' hot spots ' in geriatric research.
Frailty has been defined as a geriatric syndrome that results in high vulnerability to health adverse outcomes.
Frailty has been implicated as a causative and prognostic factor in patients with CVD.
Frailty has been shown to be associated with CKD and poorer outcomes , such as death or dialysis.
Frailty has emerged as one of the most relevant clinical syndromes in older patients.
Frailty has recently been recognized as an important priority.
Frailty index ≥0.25 was used as cut-off criteria for the diagnosis of frailty.
\ "Frailty index \ " is based on \ "deficits in health , \ " but it is still not available in Italian version.
Frailty index might facilitate the identification of older adults at high risk of dementia for the application of the most effective , targeted prevention strategies.
Frailty indices could be useful for treatment decision-making and care planning with older patients.
Frailty indices should be systematically used by health professionals to evaluate health and future risks for adverse events.
Frailty in older adults : evidence for a phenotype.
Frailty in older people is associated with a vulnerability to adverse events.
Frailty instruments were subdivided into frailty concepts , so as to make comprehensive comparisons.
Frailty in the elderly develops under the combined action of physiological aging , chronic diseases and life context.
Frailty involves the confluence of reduced strength , speed , physical activity , and endurance and is associated with adverse health outcomes.
Frailty is a biological syndrome that reflects a state of decreased physiological reserve and vulnerability to stressors.
Frailty is a clinical syndrome that is increasingly prevalent during aging.
Frailty is a common negative consequence of ageing.
Frailty is a complex and heterogeneous clinical syndrome.
Frailty is a condition associated with ageing , co-morbidity and disability.
Frailty is a condition frequently associated with low serum 25 [ OH ] D levels.
Frailty is a condition of vulnerability that carries an increased risk of poor outcome in elder adults.
Frailty is a geriatric syndrome associated with physical decline with aging.
Frailty is a geriatric syndrome that predicts disability , morbidity and mortality in the elderly.
Frailty is an emerging and immediate public health concern given the growing aging population.
Frailty is an important clinical syndrome of old age.
Frailty is an important concept in aging research and care.
Frailty is an important geriatric syndrome characterized by multisystem dysregulation.
Frailty is an increased risk of adverse health outcomes and dependency.
Frailty is an increasingly recognized syndrome resulting in age-related decline in function and reserve across multiple physiologic systems.
Frailty is a public health crisis for an aging society.
Frailty is associated with the likelihood of SCA in people living with HIV.
Frailty is a state of vulnerability that involves an increased risk of adverse events and disability in older adults.
Frailty is a still-evolving concept of a complex phenomenon.
Frailty is characterized by multisystem decline and vulnerability to adverse health outcomes.
Frailty is closely associated with PEW , muscle wasting and cachexia.
Frailty is common in HIV-infected patients , but its causes are elusive.
Frailty is considered a state of high vulnerability for adverse health outcomes for people of the same age.
Frailty is distinct from disability and disease states ; however , there is a strong relationship between frailty and heart failure and the pathophysiology's overlap.
Frailty is emerging as a syndrome of pre-disability that can identify persons at risk for negative outcomes.
Frailty is generally considered to be a degenerative but normal age-related condition in elder people.
Frailty is highly prevalent in the elderly , increasing the risk of poor outcomes that include falls , incident disability , hospitalization , and mortality.
Frailty is increasingly relevant for clinicians to improve care for vulnerable older adults.
Frailty is more prevalent at advanced ages , among women , and persons with low education.
Frailty occurred more frequently in women than in men ( @number@ versus @percent@ ) .
Frailty odds were estimated according to neighborhood using logistic regression , with the suburban neighborhood as the reference category.
Frailty predicts a range of poor health and social outcomes and is associated with increased risk of hospital admission.
Frailty prevalence and clinical characteristics are similar in affected older adults and HIV-infected persons.
Frailty prevalence estimates ranged from @percent@ ( SHARE-FRAIL ) to @percent@ ( SHARE-Groningen ) .
Frailty prevalences were compared using chi-square statistic.
Frailty prevalence was assessed with a modified version of the FFI and FRAIL scale.
Frailty refers to a physiological state of vulnerability that increases the risk of adverse health-related outcomes.
Frailty reflects a nonspecific state of vulnerability and a multi-system physiological change with increased risk for adverse health outcomes in older age.
Frailty represents a state of heightened vulnerability.
Frailty represents proximity to complex system failure , with higher-order disturbance , such as mobility and balance disturbance , as a consequence.
Frailty results from reaching a threshold of decline across multiple organ systems.
Frailty risk factors for each patient were collected at three different times over the period of a year.
Frailty , sarcopenia and immunesenescence are commonly described in older adults but are not ubiquitous to ageing.
Frailty scores on admission allow for a more complete assessment of elderly patients and can be used to establish benchmark models for burn injury outcomes.
Frailty scores were assessed from admission data and calculated using the Canadian Study of Health and Aging clinical frailty scale.
Frailty scores were obtained based on the number of frailty items present and used to evaluate the levels of frailty.
Frailty shares a number of characteristics with sleep disorders and leads to similar results.
Frailty simulations were used to assess whether causal associations were affected by mortality selection.
Frailty status ( frailty index , FI ) was measured by an index ( Rockwood index ) of accumulated deficits.
Frailty status of patients showed a trend towards significance ( P = 0.068 ) , whereas diabetes duration , age , or polypharmacy did not.
Frailty status of the participants was assessed using the Cardiovascular Health Study criteria.
Frailty status was associated with activities of daily living decline among women only.
Frailty status was classified according to the Fried criteria in @number@ visits @number@ years apart.
Frailty status was determined from physical performance testing and self reported dependency in activities of daily living.
Frailty syndrome is defined as extreme stress vulnerability and decreased potential to adapt.
Frailty syndrome was a short-term predictor of disability in nondemented older subjects and short- and long-term predictor of all-cause mortality in nondemented and demented patients.
Frailty syndrome was diagnosed in @percent@ of the AF patients who had a score of @number@ ± @number@
Frailty , the clinical manifestation of sarcopenia and physical infirmity , is associated with significant morbidity and mortality in the elderly population.
Frailty was an elusive concept earlier despite efforts at consensus.
Frailty was ascertained on the basis of weight loss , exhaustion , weakness , slowness , and low physical activity.
Frailty was assessed using both the phenotypic ( FP ) and frailty index ( FI ) models.
Frailty was assessed using standard criteria.
Frailty was assessed using the criteria of Fried's phenotype.
Frailty was assessed using the FRAIL Scale and a 32-item Frailty Index.
Frailty was assessed using the Frailty Trait Scale ( FTS ) .
Frailty was assessed using the modified frailty index ( mFI ) derived from the Canadian Study of Health and Aging ( CSHA ) .
Frailty was assessed with the frailty phenotype criteria.
Frailty was associated with age , sex , income , education , number of chronic diseases , ADL disability , and IADL disability.
Frailty was categorized according to the present of slow gait speed , weakness , weight loss , energy expenditure and exhaustion.
Frailty was classified using the Fried criteria.
Frailty was defined according the Fried et al. scale criteria and the body fat distribution was determined by multidetector computed tomography and by BIA.
Frailty was defined according to five standard criteria at the 1996-1997 visit.
Frailty was defined according to the criteria of Fried and colleagues.
Frailty was defined according to the Fried criteria.
Frailty was defined as ⩾3 of the following conditions : low muscle mass , low energy expenditure , slow running and weakness.
Frailty was defined as a FI ≥0.15.
Frailty was defined as a score of ≥3 using Fried's 5-point scale.
Frailty was defined based on an adaptation of Fried's phenotype criteria and a frailty index ( FI ) was constructed.
Frailty was defined based on frailty-defining diagnosis clusters from the Johns Hopkins Adjusted Clinical Groups frailty-defining diagnosis indicator.
Frailty was defined using Fried's criteria.
Frailty was determined by the Survey of Health , Ageing and Retirement in Europe ( SHARE ) frailty index.
Frailty was determined using the Reported Edmonton Frail Scale.
Frailty was determined using validated screening criteria.
Frailty was determined using validated screening criteria.
Frailty was diagnosed using a modified Fried's frailty criteria.
Frailty was graded based on functional loss , cognition , and urinary incontinence.
Frailty was identified by the validated physical frailty phenotype ( PFP ) scale.
Frailty was independently associated with death ( adjusted hazard ratio : @number@ @percent@ CI : @number@ @date@ ) after adjusting for known risk factors.
Frailty was measured by the frailty phenotype.
Frailty was measured using an index of accumulated deficits.
Frailty was measured using both tools in old ( ~24 months ; n = @number@ ) C57BL / 6 male mice.
Frailty was measured using the PLFI's five-item frailty index ( wasting , weakness , slowness , falls , and fatigue ) .
Frailty was measured with a frailty index.
Frailty was measured with an adapted version of the frailty index , consisting of @number@ health and age related deficits.
Frailty was operationalized using a 41-item frailty index ( FI ) .
Frailty was quantified using a 31-item frailty index.
Frailty was reversible : @number@ frail patients returned for reassessment and only @number@ were frail.
Frailty was the accumulation of health deficits.
Frail versus nonfrail persons had higher prevalence of comorbidities , falls , disability , and functional limitation.
Framework analysis was employed to identify themes arising from participants ' discussions of the causes of falls.
Framework analysis was used to explore carers ' experiences and perceptions of care with a focus on access enablers and barriers.
Frameworks were divided into four homogeneous groups with ten specimens each.
Framingham 10-year cardiovascular risks were low ( ~14% ) , did not worsen and improved by week @number@ ( P = 0·0002 ) .
Framingham risk equation was used to evaluate cardiovascular risk factors and generate FRS.
Frank J.M. Broekmans is a member of the external advisory board for Merck Serono ( The Netherlands ) , outside the submitted work.
Frank's sign was described as a predictor of future coronary heart disease and peripheral vascular diseases.
Frank's sign was present in @number@ patients ( @percent@ ) .
Frank's sign was tested in both ears.
FRAX correctly estimated fracture risk in people without mental disorders and those not taking psychotropic medications.
FRAX is a tool used to assess fracture risk in the general population.
FRAX significantly underestimated the 10-year risk of MOF by @percent@ and of hip fracture by @percent@ for those with depression.
FRAX® tool was not used in any case.
FRAX® with BMD underestimated MOF risk in the largest hip area quintile and underestimated hip fracture risk in the three largest hip area quintiles.
FRDA iPSC- cardiomyocytes retained low levels of FRATAXIN ( FXN ) mRNA and protein.
Freak-Poli R , Kirkman M , De Castro Lima G , et al.
Free androgen index and BMI were positively associated with HOMA-IR in all age quartiles.
Freedman's CDT was completed by all subjects , and the influences of disease and aging on performance in the CDT were examined.
Free DOX and liposomes without functionalization with AS1411 ( plain liposomes ) were used as controls.
Free fatty acid levels were lower in DM2 + Met than in DM2 ( AUC @number@ ± @percent@ ) .
Free flap reconstruction of complex defects has revolutionized cancer and trauma treatment and offers a reliable and efficient method for reconstructing tissue defects.
' Free from OA ' was defined as no hip or knee OA and less than three hand joints with OA.
Free ( labile or chelatable ) iron is extremely redox-active and only represents a small fraction of the total mitochondrial iron population.
Free radical derivatives from these compounds are presumed to be the prominent mediators of tumor promotion.
Free radical injury is an important effector of molecular and cellular stress in the aging brain that derives from multiple sources.
Free radical mediated pathologies occupy a special place in medical semiology and in mechanistic interpretation of diseases.
Free radicals and oxidative stress have been recognized as important factors in the biology of aging and in many age-associated degenerative diseases.
Free radicals are atoms , molecules or ions with unpaired electrons.
Free radicals are required for normal cellular metabolism , but they lead to cellular degeneration if overproduced.
Free radicals are unstable chemical species , highly reactive , being formed by cellular entities of different tissues.
Free radicals generated within subcellular compartments damage macromolecules which lead to severe structural changes and functional alterations of cellular organelles.
Free radicals serve as the main cause for premature skin aging.
Free-ranging dogs are mostly scavengers , indirectly depending on humans for their sustenance.
Free recall of relations or conjunctions was assessed.
Freesurfer , a semiautomated parcellation program , was used to analyze @number@.5T MRI scans.
FreeSurfer is a tool to quantify cortical and subcortical brain anatomy automatically and noninvasively.
FreeSurfer @number@ derived mean cortical thickness in medial temporal lobe and prefrontal regions of interest.
FreeSurfer was applied to scans collected from @number@ participants with very mild AD and @number@ cognitively normal individuals.
FreeSurfer was used for performing medial temporal lobes ( MTLs ) and brain cortical parcellation of 3T magnetic resonance images.
FreeSurfer yielded higher volume estimates than manual segmentation , particularly in the younger age group.
Free testosterone ( cFT ) was calculated.
Free testosterone concentration was calculated using concentrations of total testosterone and sex hormone-binding globulin.
Free-text responses demonstrated that residents thought that this program would change their practice.
Free-text responses showed that the program helped them understand their health concerns.
Free TFPI and PWV were positively correlated , even after adjustment for age and PP and other confounding parameters.
Free thiol β2GPI levels were significantly decreased in patients with late AMD compared with early AMD and healthy controls.
Free tissue transfer may be performed in aging patients with a high degree of technical success and low operative mortality.
Freezing or cooling procedure is the best way to decrease pain.
Freezing was not seen in naïve observers or in experienced observers that observed a subject who was spared footshock.
French prisons are experiencing the same phenomenon observed across western societies , that of an ageing population.
French subjects were significantly different from American NHANES subjects with respect to age , weight and FM.
Frequencies , distribution , interaction of genes , and correlation with infertility and IVF outcome of clinical pregnancy were analyzed.
Frequencies of peripheral T-follicular helper ( pTfh ) cells correlated with memory B-cell function and influenza A ( H1N1 ) antibody titers.
Frequencies of the GDF5 and ASPN alleles distributed differently between the early- and late-onset patients ( P < @number@ ) .
Frequencies were used to describe nutritional care , and Chi2-test to identify differences in nutritional care by NH size.
Frequency analysis of heart rate variability showed a gender-related inverse association of increased low-to-high-frequency power ratio with CBF and fractional brain flow.
Frequency and condition specific EEG-fMRI correlations proved robust for multiple brain regions.
Frequency and power differences were found between the sexes.
Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure.
Frequency based analysis to characterize walking in the test set yielded results of @percent@ area under the receiver operating characteristic curve ( AUC ) .
Frequency discrimination difference limens ( FDLs ) were obtained at @number@ and @number@ Hz using a two-interval , two-alternative forced choice procedure.
Frequency-following responses ( FFRs ) were elicited by @number@ and @number@ Hz tonebursts , as well as at frequencies within and outside those FDLs.
Frequency of apoptotic cells was higher in aged ADSC.
Frequency of BZD use varies according to various studies from @number@ to @percent@ in this age group.
Frequency of clinical strokes , headaches , and seizures was reduced from pretrial rates.
Frequency of cognitive decline was assessed using regression-based change scores.
Frequency of CV adverse events did not differ between placebo ( @percent@ ) and DMAb ( @percent@ ) groups ( p = @number@ ) .
Frequency of depressive symptoms was reported using a modified version of the Health and Daily Living form.
Frequency of preneoplastic changes increases with age.
Frequency of prescribing was adjusted for total discharges.
Frequency of unawareness was significantly higher in the unawareness variable based on performance in India.
Frequency of use is positively related to clinical outcome.
Frequent attenders were defined as patients with four or more visits during the study period.
Frequent contact with Anglos was significantly associated with a reduced likelihood of becoming frail ( relative risk = @number@ p < @number@ ) .
Frequent emotional support related to reduced feelings of loneliness and better cognitive functioning.
Frequent hospitalisation and high prevalence of nosocomial infections with the ageing is also well documented.
Frequent leg movement during sleep in patients with restless legs syndrome is associated with progression of atrial fibrillation to persistent and permanent forms.
Frequently attributed to the multi-hit hypothesis and the time required to accumulate genomic mutations , this question is a matter of ongoing debate.
Frequently , basic science results turn out to be irreproducible.
Frequently , no information is available to allow the significance of a change to be evaluated.
Frequently , the progression of cancers is also slower in aged individuals.
Frequently , these deficits are not identified during a typical \ "hearing aid evaluation. \ "
Frequently , the society considers aging as a \ "problem \ " , creating stereotypes that could result in the exclusion of the aged.
Frequent upper body bending is associated with low back pain ( LBP ) .
Fresh human FPAs ( n = 744 ) were obtained from 13-82-year-old donors.
Fresh ( raw ) Heshouwu is commonly converted to processed Heshouwu by specialized heating to alleviate its side effects of diarrhea presumably caused by anthraquinones.
Fresh samples of lateral , preparotid SMAS were then harvested and evaluated ex vivo for bursting strength , stress relaxation , and creep.
FRIDs were defined according to meta-analyses as antidepressants , neuroleptics , benzodiazepines , antiepileptic drugs , digoxin , type IA anti-arrhythmics , and diuretics.
Friedelin ( @number@ ) , epifriedelanol ( @number@ ) , and catechin-7-O- β-apiofuranoside ( @number@ ) were active in HUVECs.
Friedewald LDL-C estimation was calculated as well.
Fried's phenotype and frailty index were measured to evaluate criterion validity.
Friends , family members , and medical caretakers notice that sometimes we have good days and sometimes we have bad days.
From 3DR technique , MR pattern thought to be a superordinate concept to rete ridges.
From 5-10% of elderly residents of long-term care facilities require chronic indwelling catheters for management of urine voiding.
From a clinical perspective , allergic reactions in older adults can have the same or even worse manifestations compared to young people.
From a clinical perspective , interventions that selectively target the aging brain have the potential to prevent stroke and associated neurovascular diseases.
From a clinical perspective it is more important to consider the individual intake of energy , nutrients and water.
From a clinical point of view , hydrogel is gradually absorbed into the injection site without migration issues.
From a clinical standpoint , it is noteworthy that the respective interventions can be easily implemented in everyday care routine.
From a clinical standpoint , this may be construed as a potentially useful coping strategy.
From a clinical viewpoint , drug cessation seems most warranted in four situations , i.e. , falls , delirium , cognitive impairment and end-of-life situations.
From admission to discharge , @percent@ remained well-nourished , @percent@ remained malnourished ( SGA B or C ) , @percent@ deteriorated and @percent@ improved.
From a frequency-domain analysis , we uncovered network hyper-synchronicity as early as @number@ months , when intracellular accumulation of amyloid beta was also observable.
From age @number@ to @number@ senescence rates were comparable when calculated with or without a model.
From age @number@ years , A-T-N- prevalence declined and A + T + N + and A-T + N + prevalence increased.
From age @number@ years onward , APOE ε4 carriers had significantly greater median amyloid PET than noncarriers.
From all above cited , we concluded that in men , density and size of the FS cells increase with age.
From ancient times , garlic ( Allium sativum ) has been used to treat several diseases.
From an early age , autobiographical memory models our feeling of identity and continuity.
From an evolutionary perspective , the idea of an under developed brain which is not fit for purpose until adulthood is illogical.
From an evolutionary perspective , these longevity-associated polymorphisms do not affect the carriers ' Darwinian fitness.
From an evolutionary viewpoint , readiness to engage in appropriate behavior toward a recognized person seems to be inherent in the human brain.
From an initial model , @number@ physicians ( @percent@ ) were identified as potential outliers.
From a pathophysiological point of view , the function of the genes highlights the central role of alveolar epithelium and aging in fibrogenesis.
From a practical standpoint , adaptable interventions to enhance savoring and boost positive emotions in older adults may improve well-being and resilience to life's stressors.
From a State perspective in the short term , the advantage of these care arrangements is clear , compared to the cost of residential care.
From a theoretical point of view , it supports the relation between ToM and metamemory.
From a therapeutic perspective , we emphasize that in the fields of TBI- and aging-related neurodegeneration protective strategies should include preservation of neurovascular function.
From available evidence , it is not clear if benefits of in-hospital emergency care outweigh potential adverse complications of transfer.
From circulation to digestion to excretion , a circadian clock synchronizes most aspects of mammalian physiology with the solar day.
From conference summaries and data from a questionnaire , consensual recommendations were developed.
From cosmology , microprocessors , structural engineering , and DNA sequencing our lives are continually affected by science-based technology.
From data gathered during six regional conferences and from a questionnaire , consensual recommendations were developed.
From @date@ - @date@ , data were collected through interviews , clinical examinations , and laboratory tests.
From @date@ , the patient developed a progressively marked dorsal kyphosis with significant hypophosphataemia.
From @date@ to @date@ , he presented three episodes of disease progression.
From @date@ to @date@ , @number@ patients were recorded to have stroke within 1-year , yielding an incidence rate of @number@.81 / 1 , 000.
From @date@ to @date@ , @number@ patients were treated for deep glabellar wrinkles with ADM augmentation by the senior author.
From @date@ to @date@ , we prospectively followed @number@ pregnancies in which the foetal renal pelvis measured @number@ mm or greater.
From discussions in scientific fora within each discipline , there is now a shift towards cross-disciplinary scientific approaches.
From each subculture at passages @number@ @number@ and @number@ ( n = 4 ) , we compared gene expression profiles using mRNA sequencing.
From evolutionary perspective , high accidental death rate in young males is compatible with fast aging.
From full-volume data sets , LV endocardial and epicardial borders were semiautomatically traced using quantitative software.
From gender sensitive medicine aspect , sex hormones play most important roles in men and women's health.
From generalized additive models , the positive relationships between BMI and BMD were weaker at high BMI , particularly at the spine and in males.
From histological standpoint appears : narrowing and alteration of gingival epithelium , modification of epithelial-connective interface and decreasing of keratinization.
From interviews , the perceived benefits identified were less pain , more social contacts , fewer health concerns and fewer demands from family and friends.
From item-person maps , gaps of location of item corresponded to patient's ability were identified.
From January to @date@ , we examined treatment policies for colon cancer at our hospital.
From language to motor control , efficient integration of information from different sensory modalities is necessary for maintaining a coherent interaction with the environment.
From March to May of @number@ participants in the intervention group underwent a 2-month mutual recovery program intervention.
From microarrays studies , now it is accepted that 10-30% of the human genome is under the control of circadian molecular clocks.
From @number@ hospitalizations among @number@ hospitals from @number@ to @number@ median risk-standardized readmission rates was @percent@ ( interquartile range , @date@ @number@ ) .
From @number@ Hz onwards the thresholds increased ; this increase being more pronounced with increasing frequency and age.
From @number@ individuals who used dentures , @number@ ( @percent@ ) wore the same first denture for over @number@ years , without being examined.
From @number@ µM , MAF14001 protected SK-N-SH cells against Aβ toxicity by preventing oxidative stress , mitochondrial dysfunction and apoptosis.
From @number@ records initially screened , @number@ were included.
From @number@ the men have been regularly sent mailed questionnaires and mortality has been retrieved from national registers.
From @number@ to @number@ mean age at death increased by @number@ years , from @number@ to @number@ years.
From @number@ to @number@ @number@ HIV-infected and @number@ uninfected patients were followed for @number@ person-years.
From @number@ to @number@ @number@ incident adiposity-related cancers , including @number@ breast , @number@ prostate and sixty-eight colorectal cancers , were identified.
From @number@ to @number@ @number@ incident doctor-diagnosed obesity-related cancers were identified.
From @number@ to @number@ @number@ participants died during @number@ person-years of follow-up.
From @number@ to @number@ the mean annual changes in respiratory function were within the normal range , even though the severity of dyspnea worsened.
From @number@ to @number@ the number of cancer survivors in the United States increased from @number@ million to @number@ million.
From @number@ to @number@ tooth loss declined in the United States.
From @number@ to @number@ weeks , MCP-1 levels increased during TT versus placebo and MCP-1 levels decreased during ST + placebo versus placebo.
From @number@ to @number@ weeks , MIF and SAT decreased during ST + placebo versus placebo , whereas BioT and LBM were unchanged.
From @number@ to @number@ years of age , the myocyte compartment is replaced @number@ times in women and @number@ times in men.
From @number@ years , age should be considered as an additional risk of dying over the severity of organ failures.
From obesity policy analysis to treating malnutrition and tracking growth trajectories , the model can address diverse policy questions.
From open-loop experiments ( single-cycle analysis ) , the presence of stagnant zones and back mixing were observed.
From our historical analysis , we hypothesize several mechanisms through which artistic creativity could influence the ageing process and life expectancy.
From our literature review and experience , we recommend that the posterior capsule should remain intact.
From our perspective , level of cognitive functioning achieved by a group of elderly is largely determined by the health of individuals within this group.
From pregnancy until @number@ months postpartum , IL28B-CC allele women had a significant viral decline ( P = @number@ ) .
From six weeks on , intraneuronal Aβ could be detected which was much more abundant in homozygous mice.
From studies in New Zealand White rabbits , we found that reepithelialization and granulation tissue fill were delayed or decreased overall with aging.
From such a perspective , cancer is viewed as a tissue-based disease.
From test information plots , the lowest precision in each dataset was @number@
From that aspect , laser treatment with fractional photothermolysis may be considered to be one of the effective treatment methods for syringoma.
From the 1990s to 2000s mortality dropped , but generally more so in the upper part of the income distribution than in the lower part.
From the analysis of cell growth patterns , it is inferred that the cell aging rate is similar for each of the different considered populations.
From the approximately @number@ participants , stratified random samples were selected for detailed clinical evaluation.
From the articles , @number@ ( @percent@ ) mentioned aging or included older adults in their sample.
From the bioinformatics analysis a p. ( Arg119Trp ) variant in the SPRY2 gene was identified as the probable disease-causing mutation.
From the CCE , AH enters a deep scleral plexus ( DSP ) of vessels that typically run parallel to SC.
FROM THE CLINICAL EDITOR : Many skin disorders are characterized by an absence of a specific protein due to underlying gene mutation.
FROM THE CLINICAL EDITOR : Osteoporosis poses a significant problem in the society.
FROM THE CLINICAL EDITOR : With the aging population , osteoarthritis now poses a significant problem worldwide.
From the current research results , acupuncture plus herbal medicine may have advantages over western drugs for treating AD.
From the day we are born , our skin is exposed to an unknown environment.
From the derived linear equation , a correction grid for raw scores was built.
From the discriminative variables it was derived the HUGE formula.
From the DTFs , the ITDs , ILDs , and spectral shape cues were computed.
From the ED , @percent@ were admitted to the hospital.
From the estimated linear mixed model , we observed a significant effect of the presence of the flap ( p-value < @number@ ) .
From the evidence found , it is possible to formulate a profile of fragile older people.
From the evidence to date , there is likely a therapeutic age window relevant to the development of disease and therefore vitamin D therapy.
From the first manifestation of schizophrenic psychosis onwards numerous psychopathological symptoms and cognitive impairments occur , which are affected by age and the aging process.
From the fourth decade in both sexes lower urinary tract symptoms start to develop.
From the fourth life decade on , there was a trend for a reversed , positive association.
From the health and functional factors investigated , amongst the strongest factors associated with depressed mood was poor vision.
From their perspective , eight broad features have been identified as so-called ' Hallmarks of Cancer'.
From the landmarks , @number@ linear distances were calculated , and averaged for age and sex.
From the MNA , three scores exploring the domains of the nutritional status were calculated : body composition , energy intake and body functionality scores.
From the model , a decision rule was derived by which an overweight score could be calculated.
From the moment of birth , the human body plays host to a rich diversity of microbes.
From the @number@ articles identified originally , @number@ studies were included in this review.
From the @number@ eligible studies , @number@ were classified into part I , and @number@ studies were included in part II.
From the @number@ species identified , @number@ were distinguished in the FL20 , @number@ in OL20 , @number@ in FL82 and @number@ in OL82.
From the pattern analysis , the abnormal activity which is different from the usual patterns may be differentiated and warned.
From the perspective of preventive medicine , it is important that mold damages cannot be tolerated in indoor environments.
From the perspective of systems biology , melatonin is relevant to aging in multiple ways.
From the point of view of regenerative potential , the most important cells are pluripotent stem cells ( PSCs ) .
From the present observations , the author speculated that pathological laughing and crying may be a comparatively frequent observation in V180I CJD patients.
From the results an exemplary approach for the analysis and management of demography-related challenges for hospital employees has been deduced.
From the results of this study , we should not hesitate to offer the definitive surgery for the elderly with aSAH.
From there , the idea arose to interfere with autophagy or manipulate its regulatory signalling to help restore muscle homeostasis and attenuate disease progression.
From the same region , @number@ healthy individuals were recruited as a control group.
From these data , GSK-3β seems to regulate centrosome function.
From the segmentation , the volume was determined and a statistical shape model was constructed.
From these groups , urologic surgeons were isolated for analysis.
From the selected studies , @number@ needs of PWD were identified.
From these measures , estimated metabolic equivalent units ( METs ) were calculated.
From these men , @number@ were undergone to prostate biopsy.
From these men @number@ were undergone to prostate biopsy.
From these reports , @number@ different indices of mixed emotions were derived.
From these results , S @number@ is expected to treat memory deficits associated with early cerebral aging and neurological diseases in elderly people.
From these results , we propose the targeting of human VASH2 with neutralizing mAb as a new strategy for cancer treatment.
From these results we suggest that tumor-shed ganglioside is a secretory factor regulating the phenotype of macrophages and consequently enhancing angiogenesis.
From the therapeutic standpoint it is crucial to get an early diagnosis and start with an adequate treatment.
From the total @number@ articles retrieved , review of titles and key words were conducted.
From the trajectory file of MD simulations and a structure file , users can generate several images and statistics of ion conduction processes.
From the unique hue settings we derived the cone weightings associated with the colour mechanisms that are at equilibrium for the four unique hues.
From the viewpoint of prevention of falls , it is important to evaluate the stability of the gait in the elderly people.
From this analysis constituting factors of perceived control emerged , providing elements of a conceptual model.
From this , a subsample of @number@ individuals was selected based on age , center , and cognitive ability to undergo a detailed cognitive assessment.
From this binary graph , a thickness network is computed using nodal degree , betweenness , and clustering coefficient measures.
From this cohort , 770-790 participants were included in Cox proportional hazards regression models of survival.
From this database there were @number@ patients with MS , and @number@ patients were diagnosed with AF.
From this emerge both protective and disease-associated states in conditions such as proliferative diabetic retinopathy , macular edema , and age-related macular degeneration.
From this group of senescence-associated miRNAs , we confirmed the ability of miR-143 to induce growth arrest after ectopic expression in young fibroblasts.
From this high-dimensional DTI atlas , and using robust FT protocols , we reconstructed a large number of WM tracts.
From this , implications for practice and research are provided.
From this it would follow that longer term treatment with estrogens to maintain cognitive function is not indicated for older women.
From this perspective , most people who are treated for a \ "UTI \ " would probably be better off without treatment.
From this point of view , ageing represents the main risk for cancer acquisition.
From this point of view , the present results convey a message of hope for patients suffering from BD.
From this review , we can conclude that ADRs constitute a significant health issue for the elderly in the acute care setting.
From those @number@ trials we selected @number@ trials in each of @number@ movement end-point categories ( fast , accurate , and slow ) .
From total , @number@ ( @percent@ ) had vision problems.
Frontal and parieto-occipital hypoperfusion was observed in both DLB and AD but was more pronounced in DLB.
Frontal cortex TREM2 upregulation is a late event and may not play a major role early in the pathogenesis of the disease.
Frontal cortical thickness was measured using FreeSurfer while VBM was undertaken using the DARTEL algorithm in SPM8.
Frontal deep WMH volume was greater in hypertensive participants , whereas lower education was associated with greater posterior deep WMH volume.
Frontal-executive dysfunction , memory impairments , and dementia have been associated with essential tremor ( ET ) .
Frontal hair loss was reported by @percent@ of women.
Frontalis muscle activity was highest with maximal frowning but not with maximal eye opening.
Frontal lobe hypoperfusion combined with increased BAI scores exacerbated poorer MMSE performance.
Frontal pole ODI mediated the negative relationship of age with executive function , whereas hippocampal ODI mediated the positive relationship of age with executive function.
Frontal , temporal , and occipital FBLs explained a significant portion of variance in CPS.
Frontal theta ERS culmination peak decreased in a task-independent manner in older compared with younger cases.
Frontal theta measures of top-down engagement with distractors were selectively restrained in trained humans.
Frontal TREM2 mRNA and protein level patterns were similar but not significantly different.
Frontoparietal fMRI activation related to target detection was constant as a function of age , as was the reduction in activation associated with salient targets.
Frontoparietal regions of interest ( ROIs ) were defined from resting-state scans obtained prior to task-related fMRI.
Frontotemporal cortical and widespread white matter involvement are likely to be an effect of the disease evolution rather than a C9orf72 marker.
Frontotemporal dementia ( FTD ) is a clinically and genetically heterogeneous disorder.
Frontotemporal dementia ( FTD ) is a heterogeneous disorder with distinct clinical phenotypes associated with multiple neuropathologic entities.
Frontotemporal dementia ( FTD ) is a neurodegenerative behavioral disorder that selectively affects the salience network , including the ventral striatum and insula.
Frontotemporal dementia ( FTD ) is a progressive neurologic syndrome with diverse clinical presentations and attendant underlying pathologies.
Frontotemporal dementia ( FTD ) symptoms cause more pronounced stress and burden on caregivers than those associated with Alzheimer dementia.
Frontotemporal dementia is a heterogeneous neurodegenerative disorder with around a third of cases having autosomal dominant inheritance.
Frontotemporal dementia is associated with profound changes in behavior , personality , emotions , and cognition.
Frontotemporal dementia was documented over a century ago.
Frontotemporal lobar degeneration ( FTLD ) has two pathological types : tau-positive and tau-negative.
Frontotemporal lobar degeneration ( FTLD ) is a common cause of dementia especially in patients under the age of @number@
Frontotemporal lobar degeneration ( FTLD ) is a group of neurodegenerative diseases displaying high clinical , pathologic , and genetic heterogeneity.
Frontotemporal lobar degeneration is a highly familial disease and the most common known genetic cause is the repeat expansion mutation in the gene C9orf72.
Front passenger seats had the highest risk to elderly occupants , while the driver seat was statistically insignificant.
FrPC are associated with negative consequences including physical , psychological , and social.
FR to ICA distance was very small in some patients ( minimum @number@ mm ) .
Fructose is a hexose sugar that is being increasingly consumed in its monosaccharide form.
Fructose , like other reducing sugars can react with proteins , which may account for aging and myocardial infarction.
Fructose malabsorption appears to be partially modulated by the amount of glucose ingested.
Fructose participates in glycation ( fructation ) and AGE formation some @number@ times faster than glucose.
Fruit and vegetable consumption had a strong effect on self-rated health among women , but not men.
Fruit and vegetable ( FV ) intake is associated with reduced risk of a number of non-communicable diseases.
Fruit and vegetable intake was assessed using short questions.
Fruits and tannin-rich extracts of fruits have shown antidiabetic , antimicrobial , anti-inflammatory , and immune-regulating activities in vitro and in animal studies.
Fruits of emblic leafflower have been used as food and traditional medicine in Asia.
FSD encompasses both physical and emotional components , all of which are often intermingled.
FSH binds to FSH receptors ( FSHRs ) and regulates estrogen production in ovarian granulosa cells to orchestrate female reproductive physiology.
FSH was observed to be a later predictor of biological age than AMH and AFC.
FS showed widely differing degrees of agreement with the mean of all scores and between each pair of scores.
FS was assessed using a Trauma-Specific Frailty Index ( TSFI ) .
FS was diagnosed in @percent@ of the study subjects.
FT3 , FT4 , and TSH levels from @number@ sera samples taken from patients age @number@ year or greater were included.
FT4 declines to a lesser extent , also more among females than among males.
FT4 only was associated with any and nonvertebral fractures.
FT4 was assessed as study-specific standard deviation increase , because assays varied between cohorts.
FT and FLT participants undertook a 15-min training session involving @number@ step repetitions.
FTD needs to be differentiated from other forms of dementia and from psychiatric conditions such as schizophrenia.
FTH was used to estimate the body density , from which fat mass and fat-free mass ( FFM ) was calculated by using Brozek equation.
FTIR and DSC showed no interaction between EGCG and the selected excipients.
FTLD has a high incidence of heritability with as many as @percent@ of patients reporting a family history of disease.
FTSS could be used as a tool in primary care medicine to exclude moderate cognitive decline.
FTS showed similar predictive value to the Frailty Index.
Fuelled by new sequencing technologies , epigenome mapping projects are revealing epigenomic variation at all levels of biological complexity , from species to cells.
Fuji II LC cement was used as control.
[ Full article available at @url@
[ Full article available at @url@
Full blood count was measured on each occasion.
Full-contour zirconia FDPs caused concern about the wear of antagonist enamel , because the hardness of Y-TZP was over double that of porcelain.
Full data were available for @number@ participants.
Full English text available from : www.revespcardiol.org.
Full-face laser resurfacing was performed in @percent@ of patients , with @percent@ receiving their treatment under local anesthesia without sedation.
Full-field electroretinogram ( ERG ) evaluates the function of the entire retina evoked by a flash light.
Full history taking , general and local examinations as well as nail biopsies were performed from selected cases with age-related nail changes and disorders.
Full recovery is the main goal in the treatment of depressive episodes.
Full text was retrieved and screened against inclusion / exclusion criteria.
Full-thickness macular hole is primary if caused by vitreous traction or secondary if directly the result of pathologic characteristics other than VMT.
Full-thickness macular hole is subclassified by size of the hole as determined by OCT and the presence or absence of VMT.
Full validation will require follow-up assessments ( currently under way ) .
Fully adjusted models included income quintile , marital status and education.
Fully adjusted models included terms for depression , vascular diseases and risk factors , body mass index , social networks , and self-reported physical activity.
Fully educating residents in emergency geriatric care can demand large amounts of limited conference time.
Functional Activities Questionnaire was used to determine activities of daily living.
Functional analysis identified p53 as the most overrepresented pathway that is specifically enhanced and prolonged in 6-month-old mice.
Functional analysis in NSC34 cells showed that the overexpression of the mutant form of SOD1 ( V31A ) induced aggregates and decreased cell viability.
Functional analysis of differentially expressed miRNAs via the miR-path indicated that miR-455-3p was associated in the regulation of several biological pathways.
Functional analysis showed that fibroblasts from both patients have a dramatic reduction in BAF protein levels , indicating that the p.Ala12Thr mutation impairs protein stability.
Functional analysis using in silico approaches indicated associated SNP rs3024498 \ "C \ " allele being the local expression quantitative trait locus.
Functional and cognitive deficits were associated with higher risks of for some ACS but not all admissions.
Functional and cognitive deficits were significantly associated with higher risks for hospitalizations , hospital LOS , and Medicare expenditures.
Functional and cognitive status were evaluated at baseline and after treatment.
Functional and part / whole relations develop at an early age , whereas the superordinate relations develop later.
Functional and pharmacological control of these dynamic relationships may result in treatments that are more effective with fewer side-effects.
Functional and structural magnetic resonance imaging ( using 3T MRI ) was performed in @number@ subjects with social anxiety disorder on @number@ occasions over 1year.
Functional and structural neuroimaging data were acquired at baseline and @number@ weeks after treatment initiation.
Functional annotation showed enrichment for genes expressed in immune and kidney cells , as well as in heart and vascular cells / tissues.
Functional approaches to working memory ( WM ) have been proposed recently to better investigate \ "maintenance \ " and \ "processing \ " mechanisms.
Functional assays revealed that NK cell killing activity and degranulation ( CD107 expression ) were unchanged in the three groups.
Functional assays using ex vivo liver tissue sections demonstrate that Klf11- / - mice display increased insulin sensitivity.
Functional assessment included Barthel Index of Activities of Daily Living ( Barthel Index ) , Instrumental Activities of Daily Living Scale and Mini-Mental State Examination.
Functional assessment in RMA values shows the better results in women ( @number@ ± @number@ ) than men ( @number@ ± @number@ ) .
Functional assessment methods are an important element in multidimensional neuropsychological evaluations , particularly in older adults.
Functional assessment parameters may be least well correlated with nutrition status in older individuals.
Functional assessment showed reduced surface expression of p.G257R and decreased GABA-evoked currents for p.R323Q.
Functional autonomy was assessed by the Barthel Index.
Functional balance impairment is present in early COPD , although more evident at advanced grades.
Functional balance impairment was defined as a TUG score exceeding the upper limit of the confidence intervals of normative values for healthy older adults.
Functional balance impairment was present in @percent@ of the participants and was significantly more frequent in severe to very severe COPD ( @percent@ ) .
Functional blocking of c-Jun significantly reduced CCN1 promoter and gene expression and thus prevented ROS-induced loss of type I collagen.
Functional brain alterations at rest or during task performance have been captured with functional and arterial spin labeling perfusion MRI.
Functional brain imaging studies of normal aging typically show age-related under- and overactivations during episodic memory tasks.
Functional brain imaging techniques appear ideally suited to explore the pathophysiology of freezing of gait ( FOG ) .
Functional brain organization was tested in postmenopausal women using either estrogen therapy or combined estrogen plus gestagen therapy.
Functional capacities of organisms most likely emerged in a chain of modifications and combinations of more simple ancestral functions.
Functional capacity and body composition showed significant improvements with eccentric endurance protocols , especially in older , frail or sedentary cohorts.
Functional capacity improved for the CG and the HG.
Functional capacity is tested using objective measures of lower body strength , balance , and walking speed.
Functional capacity was assessed by the instrumental activities of daily living scale.
Functional capacity was measured with the @number@ min walk test , the timed \ "up and go \ " test and a stair climbing test.
Functional cardiac abnormalities have been reported in patients with NAFLD.
Functional characterization of the disease-causing mutations in BHD syndrome may guide further research for the development of novel diagnostic and therapeutic strategies.
Functional component weights were calculated and compared with mixed model repeated measures ANOVAs.
Functional connectivity analysis further showed gaze-dependent engagement of a large-scale network connected to bilateral amygdala during the recognition of angry expressions.
Functional connectivity , a very common approach in resting-state fMRI analysis , is scaled for variance.
Functional connectivity between @number@ cortical and subcortical regions was estimated by wavelet correlation analysis in the frequency interval of @number@ @date@ Hz.
Functional connectivity encompassing these regions , within default and salience networks , was reduced , while between network connectivity was increased.
Functional connectivity estimates correlations in the time course of low-frequency activity.
Functional connectivity ( FC ) of the default mode network ( DMN ) is a plausible candidate for such a biomarker.
Functional connectivity in young and older participants was assessed during resting-state fMRI.
Functional consequences were investigated by RNA studies and on the cellular level using immunofluorescence and microscopy.
Functional data from a zebrafish model further demonstrated that mutant Mdm2 was unable to rescue a p53-induced apoptotic phenotype.
Functional decline and mortality were assessed at T2 ( 2008 / 2009 ) .
Functional decline in older people is associated with age , gender , depression , up and go test and manual dexterity.
Functional decline is experienced by 30-60% of the older hospitalized patients , resulting in decreased independence and other adverse health outcomes.
Functional decline was defined as a decline of at least one point on the Katz ADL Index at follow-up compared with preadmission status.
Functional defects of telomerase gene mutations were investigated in primary human fibroblasts and patient-derived lymphocytes.
Functional dependence and social isolation contributed most to worse HRQoL.
Functional dependence was defined as being dependent in at least one activity in the personal or instrumental activities of daily living.
Functional dependence was worse among females.
Functional differences and distinct responsiveness to TNF-a were observed according to patient's age.
Functional disability in IADL also decreased between the cohorts ( @number@ versus @percent@ , P < @number@ ) .
Functional disability was assessed by the Katz Index of Independence in activities of daily living.
Functional disability was defined as the dependence for two or more ADLs or IADLs.
Functional disability was measured using activity of daily living ( ADL ) and instrumental activity of daily living ( IADL ) .
Functional efficiency is the ability to be independent in fulfilling the basic needs of everyday life.
Functional experiments revealed defective checkpoint signaling and escape of DNA replication intermediates into mitosis and the next generation of XPC-depleted cells exposed to RS.
Functional fitness was assessed using the Senior Fitness Test.
Functional grouping indicated that genes involved in inflammatory / immune signaling were the most enriched class of genes induced by miR-132 knockdown.
Functional health status was significantly higher for urban older adults than their rural counterparts.
Functional health tapped mobility and disability.
Functional health was assessed with SF-36 physical health summary scale and Patient Reported Outcomes Measurement Information System short form subscales for depression and anxiety.
Functional health was quantified by the subscale ' physical functioning ' of the 36-Item Short Form Health Survey ( SF-36 ) .
Functional hypothalamic amenorrhea , a phenotypically recognizable form of stress , is due to stress-induced suppression of endogenous gonadotropin-releasing hormone secretion.
Functional images were collected using a gradient spin-echo sequence sensitive to BOLD contrast ( T2 weighting ) .
Functional imaging has revealed both distinct characteristics of LLD and overlap of some cognitive symptoms with other dementias.
Functional imaging studies indicate that hippocampal and medial temporal lobe cortices are the sites of early pathology underlying the initial memory impairments.
Functional impairment due to ALS was evaluated using the ALS-Functional Rating Scale-Revised ( ALS-FRS ) and the ALS severity scale ( ALSSS ) .
Functional impairment was defined as self-reported impairment in self-care , mobility or household tasks.
Functional impairment was measured using a Back Pain Functional Scale.
Functional improvement was not found to mediate the intervention's effect on depressive symptoms.
Functional independence is significantly influenced by age , educational attainment , place of residence after admission , housing adaptation and formal support.
Functional Independence Measure ( FIM ) scores were measured both at admission and discharge to calculate FIM gain and efficiency.
Functional investigation demonstrated that VEGF shows several important effects on the neuronal development and physiological function.
Functionality was assessed by @number@ m walk test , Timed up and Go ( TUG ) performance and endurance capacity ( Shuttle Walk ) .
Functionalized multi-walled carbon nanotube ( fMWCNT ) development has been intensified to improve their surface activity for numerous applications , and potentially reduce toxic effects.
Functional levels , depression , and social interactions were assessed.
Functional limitation and stressor exposure are also associated with declines in stigma in the context of greater mastery and self-esteem.
Functional limitations included difficulties with basic activities of daily living tasks , instrumental activities of daily living tasks , and mobility.
Functional limitations were significantly associated with older age , skeletal muscle mass and total body fat.
Functionally , an individual miRNA can regulate the expression of multiple target genes.
Functionally , experiments in HeLa cells demonstrate that TDP-43 is necessary for the inhibitory activity of Hrp38 on splicing.
Functionally independent older people at baseline ( The nucleolus is the subnuclear membrane-less organelle where rRNA is transcribed and processed and ribosomal assembly occurs.
Functionally , REGγ is crucial for the migration of HUVECs.
Functionally relevant motor dysfunction was assessed via self-report of falls within the past year.
Functional magnetic resonance imagery indicates that the brain is more active in persons with MCI than in normal people.
Functional magnetic resonance imaging data indicated significant effects of age as well as interactive effects with metabolic syndrome and hunger condition.
Functional Magnetic Resonance Imaging ( fMRI ) is a powerful neuroimaging tool , which is often hampered by significant noise confounds.
Functional magnetic resonance imaging ( fMRI ) is a valuable tool for monitoring disease progression in selectively vulnerable brain regions associated with AD neuropathology.
Functional magnetic resonance imaging ( fMRI ) provides a unique view of the working human mind.
Functional magnetic resonance imaging was used to measure the BOLD-response in @number@ old and @number@ young healthy adults while performing tasks separately , or combined.
Functional mobility was assessed with three endpoints : normal and fast walking speed and the Timed Up and Go ( TUG ) test.
Functional mobility was determined using the Timed Up and Go test ( TUG ) and muscle strength with the handgrip strength test.
Functional motor declines that often occur with advancing age-including reduced efficacy to learn new skills-can have a substantial impact on the quality of life.
Functional MRI and PET studies have indicated the decline in working memory performance in older adults.
Functional MRI ( fMRI ) has been used to compare auditory and visual system pathways , as well as resting-state networks of connectivity.
Functional MRI studies found evidence of premature or accelerated aging processes in the brains of HIV subjects.
Functional MRI was acquired at rest ; the PCC / precuneus was used as a seed for correlated brain activity maps.
Functional Near-Infrared Spectroscopy ( fNIRS ) is a novel neuroimaging tool that can detect brain activities during dynamic movement condition.
Functional neuroimaging studies have shown age-related differences in brain activation and connectivity patterns for emotional memory.
Functional neuroimaging techniques have allowed for investigations into the mechanisms of age-related deterioration in motor control.
Functional ontology terms and transcriptional profiles co-vary with CGI clusters , indicating that the regulatory functions of CGIs are tightly linked to their heterogeneity.
Functional OR ( FOR ) depends on size of the follicle pool at menarche and the follicle recruitment rate.
Functional outcomes were very similar to those of @number@ patients with early IV-tPA recanalization.
Functional outcome was assessed using the Enneking Scoring system.
Functional outcome was evaluated at 6-month using the modified Rankin scale ( m-Rankin ) .
Functional p53 utilizes a plethora of mechanisms to protect cell from deleterious repercussions of genotoxic insults , where senescence deserves special attention.
Functional parameters declined and age-related morphological changes increased in late generation Terc ( - / - ) mice and with further age.
Functional performance increased through childhood and adolescence , plateaued during adulthood , and declined in older adulthood.
Functional performance of lower urinary tract ( LUT ) at enrollment and at the end of the treatment was evaluated using ICIQ-SF questionnaires.
Functional performance was assessed using a @number@ repetition and 30s chair rise test and 900m gait speed test.
Functional performance was measured with De Morton Mobility Index ( DEMMI ) test and a 30-second chair stand test ( 30-s CST ) .
Functional properties of the chaperome were assessed by perturbation in C. elegans and human cell models expressing Aβ , polyglutamine , and Huntingtin.
Functional recovery occurs with sustained sobriety , but the neural mechanisms enabling recovery are only now emerging.
Functional resting-state networks usually display the characteristics of small-world networks and their statistical properties have been observed to change due to pathological conditions or aging.
Functional state of the red blood system is being studied in patients with adenoma and carcinoma of thyroid gland.
Functional state of the red blood system is being studied in patients with adenoma and carcinoma of thyroid gland.
Functional status and survival status was followed for @number@ years.
Functional status benchmarks for age were developed with curves plotting activity difficulty percentiles versus age for the general U.S. population.
Functional status is measured using an index of activities of daily living ( ADL ) and instrumental activities of daily living ( IADL ) .
Functional status was assessed using the modified Rankin scale ( RS ) and the Barthel index ( BI ) .
Functional status was assessed using the Older Americans Resource Survey , which was dichotomized into no / mild disability versus moderate / severe disability.
Functional status was assessed with the evaluation of activities of daily living ( ADL ) and instrumental activities of daily living ( IADL ) scales.
Functional status was categorized into no dependence , dependence only in instrumental ADL and dependence in basic ADL.
Functional status was determined once at the 10-year follow-up by the Older Americans Resources and Services activities of daily living scale.
Functional status was evaluated using the Disabilities of Arm , Shoulder and Hand ( DASH ) instrument.
Functional studies are needed to clarify the possible mechanisms by which rs2229901 influences MDD risk.
Functional studies in fibroblasts from affected subjects showed both an apparently complete loss of MDH2 levels and MDH2 enzymatic activity close to null.
Functional studies revealed that miR-96 and miR-182 interacted with human IGF-1R mRNA , and that miR-145 and miR-132 interacted with human FOXO1 mRNA.
Functional studies showed that Neph3 homodimerization and Neph3-Nephrin heterodimerization are disturbed by variant 353M.
Functional task performance was assessed using multiple chair rise and stair climb tests.
Functional tests were based on a battery adapted from the Functional Fitness Test.
Functional variants in these loci are still unknown.
Functional voice testing was performed using the Kay Elemetrics-Computer Speech Lab to determine voice frequency , volume , and harmonics.
Function and cognition were measured using the Katz Index , the Tinetti Balance and Gait , lower extremity function tests and the Mini-Mental test.
Function and frailty measures best predict perioperative morbidity.
Function , cognition , depression and pain were assessed using interRAI LTCF with selected items completed by researchers with care staff.
Functioning in the memory domain was significantly lower in older subjects ( P = @number@ ) .
Functioning of the axis is altered in aging , and the pathway may represent a plausible target to slow the process of aging.
Function in the average 50-year old HIV-infected subject was equivalent to the average @number@.5-year-old uninfected subject.
Function of one such lead compound was confirmed by its activity in suppressing influenza virus replication.
Function of the binding activity was confirmed using TP53- , AP-1- and NF-κB-specific REs or p21 , SERPINE1 and IL-6 promoter luciferase reporter activities.
Function of Trx1 has been implicated in regulating cell proliferation , differentiation , and apoptosis.
Function parameters were estimated using a nonlinear least squares procedure.
Functions of MVBs in neurons have been much neglected , and major gaps in knowledge currently exist.
Functions of Toll-like receptors @number@ and @number@ and the natural killer activity were significantly downregulated in patients with oral candidiasis compared with healthy volunteers.
Functions were assess within the main structural components as spouse , parents , children , grandchildren , other relatives , friends , coworkers and neighbours.
Function was assessed by questions measuring four physical abilities and five instrumental activities of daily living.
Function was assessed from gait speed and knee extensor strength.
Function was evaluated as the number of functional limitations ( 0-10 ) .
Fundamental changes are needed to improve health outcomes and reduce costs.
Fundamental studies of genetic influence on the brain will help inform gene discovery initiatives in both clinical and normative samples.
( Funded by Amgen and UCB Pharma ; FRAME ClinicalTrials.gov number , NCT01575834 . ) .
( Funded by Daiichi Sankyo ; Hokusai VTE Cancer ClinicalTrials.gov number , NCT02073682 . ) .
( Funded by Eli Lilly ; EXPEDITION3 ClinicalTrials.gov number , NCT01900665 . ) .
( Funded by European Union FP7 and others ; TRUST ClinicalTrials.gov number , NCT01660126 . ) .
( Funded by F. Hoffmann-La Roche ; ClinicalTrials.gov number , NCT01010061. ) .
( Funded by Merck ; MODIFY I and MODIFY II ClinicalTrials.gov numbers , NCT01241552 and NCT01513239 . ) .
( Funded by the Bill and Melinda Gates Foundation and others. ) .
( Funded by the Italian Foundation for Multiple Sclerosis and others. ) .
( Funded by the National Institute on Aging. ) .
( Funded by the National Institute on Aging. ) .
( Funded by the National Institute on Aging. ) .
( Funded by the National Institute on Aging. ) .
( Funded by the National Institute on Aging and others. ) .
( Funded by the National Institute on Aging and others. ) .
( Funded by the National Natural Science Foundation of China and others ; Chinese Clinical Trial Registry number , @number@ . ) .
Funders granting money to research institutions increasingly express interest into how their financial resources are used and look for successful translation in clinical practice.
FUNDING : AstraZeneca Pharmaceuticals.
FUNDING : British Heart Foundation , UK Medical Research Council , and Academy of Finland.
FUNDING : Centres of Excellence in Neurodegeneration.
FUNDING : Compagnia di San Paolo , Fondazione Cariplo , European Commission , and Italian Ministry of Health.
FUNDING : European Community's Seventh Framework Programme.
Funding interruption led to @percent@ working additional hours over and above an increased clinical workload to continue their GACA-related research and scholarship.
Funding issues were the most prevalent reported factors adversely affecting long-term care development.
FUNDING : Italian Ministry of Health , European Commission , Compagnia di San Paolo Foundation , Cariplo Foundation.
FUNDING : National Institute on Aging , National Institute of Neurological Disorders and Stroke , and the Michael J Fox Foundation.
FUNDING : National Institutes of Health and Cancer Center Support.
Funding reform of long-term care would prioritize home care and optimize the functioning of integrated care to improve support for frail older people.
FUNDING : TauRx Therapeutics.
FUNDING : The Alzheimer's Society and the Lewy Body Society.
FUNDING : The National Institutes of Health , the National Multiple Sclerosis Society , and the Mayo Clinic Robert and Arlene Kogod Center on Aging.
FUNDING : US National Institute on Aging and UK Medical Research Council.
FUNDING : US National Institute on Aging ( National Institutes of Health ) .
FUNDING : US National Institutes of Health.
FUNDING : US National Institutes of Health ( National Institute on Aging and National Institute of Neurological Disorders and Stroke ) .
FUNDING : Wellcome Trust , National Institute on Aging , and US Department of Defense.
Fundus autofluorescence mostly originates from bisretinoid fluorophores in lipofuscin granules , which accumulate in cells with age.
Funduscopically there were pigment epithelial changes.
Fundus photographs were graded for the presence or absence of AMD.
Fungal infections are both difficult to prevent and difficult to treat.
Fungal isolates included Rhizopus spp.
Fungi are major causes of infections among immunocompromised or hospitalized patients with serious underlying diseases and comorbidities.
Funnel plots and Egger's tests were utilized to evaluate for the presence of publication bias.
Funnel plots were carried out to evaluate publication bias.
Further , about @percent@ of the family caregivers reported a high level of financial stress as a result of caregiving for their elderly relative.
Further abstract screening yielded @number@ articles , out of which @number@ were found potentially appropriate to be included.
Further adjusting for physical activity , smoking status and use of alcohol increased the variation explained by an additional @percent@.
Further adjustment for body mass index ( BMI ) attenuated these associations , but the associations with adipokines remained significant.
Further adjustment for bone mineral density ( BMD ) resulted in an attenuated but still significant association between serum IGF-1 and fracture risk.
Further adjustment for family history of diabetes , lifestyle , and other confounding factors did not appreciably change the magnitude of these associations.
Further adjustment for midlife dietary patterns slightly attenuated these associations.
Further adjustment for ozone and fine particulate matter ( PM2.5 ) did not materially alter the results.
Further adjustment for physical activity , smoking , education , and body mass index attenuated the association slightly.
Further , a gap remains between investigational treatments and our evolving theories of brain function.
Further , aged adult valve tissue had decreased stiffness in both the cusp and annulus.
Further , age-related declines in object processing effects in extrastriate regions correlated with poorer source accuracy for objects.
Further , age-related differences in brain activity were mostly observed in early ERP components.
Further aging of the cohort and extension of the follow-up period will enhance the statistical power of this study in the future.
Further aging times decreased the sensorial quality of Albariño wine and modified its volatile profile and mannoprotein concentration.
Further , a higher value on the relationships index ( sum of all variables ) was associated with reduced risk of all-cause dementia and AD.
Further , all clinical trials using neuroprotective or anti-inflammatory drugs for treatment of HIV-associated neurocognitive disorders have been unsuccessful.
Further , all subjects in the GrHu group showed a significant reduction in the energy used during a 4-min walk.
Further , a longitudinal perspective was added by carrying out a spatial analysis including the territorial patterns of past mortality.
Further , amygdala response in adolescents was negatively correlated with the personality trait impulsivity.
Further analyses indicated that age was a significant mediator of the relation between each component and perceptual-motor speed.
Further analyses indicated that @percent@ of the differentially expressed genes are influenced by genetic variants in cis.
Further analyses revealed lack of correlation among females , and variable association among males , depending on the subject age and season of measurements.
Further analyses revealed that different psychosocial and health-related factors such as pain , loneliness and personality accounted for scores in the different components.
Further analyses revealed that ethnicity differences could not be explained by differences in linkage disequilibrium , lipid lowering drugs , diabetes , or gender.
Further analyses revealed that when controlling for performance effects older age was associated with greater activation of left temporal and right frontal cortex.
Further analyses showed three components of this score reached significance : constructional praxis , delayed recall of a word list , and category verbal fluency.
Further analyses suggest that hyperphosphorylated tau or oligomeric tau is involved in synaptic loss , whereas granular tau oligomers are responsible for neuronal loss.
Further analyses will be required to gain more information about the SEM in different age groups or ID-level groups.
Further analysis demonstrated that correlations between tau and a weighted executive function composite were significant only in the old-old group.
Further analysis did not show the dosage effect of ε4 pertinent to AAO , though the AAO of ε4ε4 patients decreased by @number@ years.
Further analysis following the time course revealed that right-side parietal TMS had almost no effect on the frontal cortex in the elderly participants.
Further analysis in a large stroke cohort showed that these education effects were fully mediated by age , even in relatively young stroke patients.
Further analysis of data from prospective cohort studies is warranted , especially regarding the role of pork.
Further , analysis of estimates of discriminability provides substantial-to-strong evidence against this suggestion.
Further analysis of family members of the proband with the p.R1441G mutation revealed that her mother and first cousin shared the same mutation and parkinsonism.
Further analysis of human B lymphocyte subpopulations is required that could be regarded as an important biomarker of human life span.
Further analysis of individual age groups revealed that kinesthetic sensitivity was worse in DCD than TD children for age groups beyond six years of age.
Further analysis of @number@ randomly selected patients identified @number@ previously unknown problems ( @number@ per patient ) .
Further analysis of the data identified a relationship between alcohol intake and CSF [ NAD ( H ) ] and markers of inflammation.
Further analysis of versican indicates that four major core protein species are present in human skin at all ages examined from fetal to adult.
Further analysis revealed distinct , but overlapping , disease-associated loci for early- and late-onset forms of myasthenia gravis.
Further analysis revealed that HuR did not influence CircPABPN1 abundance ; interestingly , however , high levels of CircPABPN1 suppressed HuR binding to PABPN1 mRNA.
Further analysis revealed there were a greater number of cerebral infarcts associated with frontal DWMH ( p = @number@ ) but not with frontal PVWMH.
Further analysis showed a dose-response association between alcohol ( p-trend = @number@ ) or wine ( p-trend = @number@ ) and TBV.
Further analysis showed a tendency of activating WASP mutants to localize in the nucleus compared with WT or the Y291F mutant of WASP.
Further analysis showed IGF1R antibody-induced hypophosphorylation of BAD and activation of downstream BAX.
Further analysis showed that RPA could be displaced from both substrates by WRN.
Further analysis showed that the beneficial effect of social activity on mental health was particularly strong among those with lower levels of acculturation.
Further analysis showed that the prevalence of HPV infection significantly increased from @number@ to @number@
Further analysis suggested that BMI trajectories were more predictive of mortality risk than was static BMI status.
Further analysis using a haplotype-based approach showed similar findings.
Further analysis will examine the impact on the quality of life and the relationship with existing classificatory systems.
Further , animal studies report contradictory data.
Further , an increase in mitochondrial oxidative stress in MCI is associated with MMSE score , vitamin E components , and β-carotene.
Further , anti-thrombotic treatment seems to work less in the elderly population.
Further , an update on the current advancements in technologies to improve longevity and efficiency of these compounds for field applications has been provided.
Further , a positive relationship between caudate BOLD activation and updating performance among non-A1 carriers indicated that caudate activation was behaviorally relevant.
Further arguments based on stability and heat loss suggest that p should be close to @date@ .
Further assessment of frailty in patients experiencing OI is a potential opportunity for early intervention to delay functional decline.
Further assessment of the tool's validity with larger and varied samples is necessary.
Further associations included maximal exercise capacity , blood pressure , heart rate and the rehabilitation centre attended.
Further astroglial markers include connexin-43 , excitatory amino acid transporters , aquaporin-4 , heat shock protein Hsp27 , and α-B-crystallin.
Further , BACE1 is a downstream target of p53 and overexpression of p53 decreases BACE1 level.
Further basic and clinical studies investigating the role for androgen on metabolic parameters and atherosclerosis are needed.
Further , BD and control subjects did not differ with respect to total gray and hippocampal volumes.
Further , because aging especially disrupts frontal functioning , the above noted prospective memory tasks would thus be expected to display the greatest age-related decline.
Further bioinformatics predicted that one target of miR-107 may be Cacna2d1 , a calcium channel protein.
Further , body composition will be analysed using a bioelectrical impedance analysis system.
Further , both fetal corneal epithelial cultures and limbal stem cell cultures from adult human tissues were positive for lens crystallin immunofluorescence or immunohistochemistry staining.
Further candidate genes were detected from long-range regulatory chromatin interactions in heart tissue ( SCD , SLF2 and MAPK8 ) .
Further , changes in the intestinal microbiota most likely influence mucosal immunity.
Further characterisation of this intricate viral-host signalling may provide new prognostic biomarkers and therapeutic targets for HCC treatment.
Further characterization of the glymphatic system in humans may lead to new therapies and methods of prevention of neurodegenerative diseases.
Further characterization of their functionality and assessment of sustenance in HIV infection will help to understand the HIV pathogenesis and to develop immune therapies.
Further characterization of these molecules may have important ramifications for drug discovery , especially in the area of CNS diseases.
Further characterizing this genetic risk will influence clinical practice in terms of categorization , diagnosis , and screening of individuals for this disease.
Further , CH , CRF , and CCT were significantly related.
Further , chondroprotective effects of lubricin normalized bone remodeling in subchondral bone underneath.
Further , chromatin immunoprecipitation with Tip60 localizes the protein to the same 110bp stretch of the cdc2 promoter pulled down by MRG15.
Further clinical evaluations at @number@ and @number@ months will therefore be needed to identify a suitably convenient interval between two consecutive procedures.
Further clinical studies are needed to confirm the pharmacokinetic parameters of digoxin in elderly patients with heart failure and / or atrial fibrillation.
Further clinical studies are needed to determine other essential parameters for the design of prosthesis to the Chinese populations.
Further clinical studies with larger sample sizes and longer follow-up periods are required to investigate the possible influencing factors of technical failures.
Further , clinical trials must be conducted in the ED in order to improve the evidence base and drive optimal initial therapy for AHF.
Further , CMRglc in orbitofrontal cortex , DLPFC , and ACC was shown to be early modulated by the level of DA impairment in CN.
Further , cognitive function mediated through the dorsolateral prefrontal cortex ( DLPFC ) also declines with age.
Further comparative genotyping of C. trachomatis in ocular and genital specimens might give more detailed epidemiological information about the aetiology of the disease.
Further comparative research is needed.
Further comparative research on the relative importance of explanatory pathways assessed over time is needed.
Further confounding problems include an insufficient transferability of animal to human physiology , as well as intersubject group variability , for example , sexual dimorphisms.
Further connections between the SUMO pathway and the aging process remain to be elucidated.
Further consideration of art galleries and museums , as non-clinical community resources for dementia care , is warranted.
Further consideration of genotype effects indicates preclinical effects of APOE ε4 may be observable in memory and executive functioning.
Further consideration should be given to using IM fixation in the management of AFFs in older people.
Further , contemporary octogenarians in the later sample performed like septuagenarians in the former sample.
Further controlled studies are needed to clarify the benefits and risks of stimulants , both in bipolar depression and mania.
Further , correlations between ADMI and BMeHg were compared between Asians and other racial / ethnic groups.
Further CT follow-up after response at day @number@ was of low additional value.
Further , data are scant on the effect of age on the rate of muscle relaxation when the muscle is contracting voluntarily.
Further decline in mortality hazard was observed after adjustment for other measured factors.
Further , decreased amygdala activation to sad faces predicts lower internalizing symptoms.
Further definition of the mechanisms leading to their formation in the human brain will provide insights into the cellular causes of AD.
Further development of predictive biomarkers will be useful in the selection of patients who will benefit from inhibition of the mechanistic target of rapamycin pathway.
Further development of such beneficial programs is warranted.
Further development of trial methods is required to accelerate progress in this important area of medicine for older people.
Further development of vision screening in the workplace is supported.
Further development work and testing is needed to explore whether this type of data modelling and visualisation might improve patient care.
Further , diagnosing skin diseases , for example , malignant melanoma , also can present challenges.
Further , differential age-related effects of verbalization were also obtained.
Further , discharge destination was documented.
Further efforts should be made to confirm these findings and clarify the underlying biological mechanisms.
Further elucidating the estrogen gene cascade is critical for advancements in the diagnosis and treatment of breast cancer.
Further elucidation of the genetic architecture of this disease will help clarify the role of genetic variation in ALS populations.
Further elucidation of the underlying mechanisms is needed to enable the development of new and effective treatment approaches.
Further empirical research is needed that explicitly focuses on caregivers ' experiences of security and insecurity in the domains identified in this article.
Further empirical research is needed to assess the validity of our complexity framework in the health-care environment.
Further epidemiological studies of SPs are needed to aid in risk stratification and screening , and etiological research.
Further evaluation is needed to confirm the predictive power of these models on larger cohorts of samples.
Further evaluation is warranted.
Further evaluation needs to be undertaken to assess the effectiveness of START.
Further evaluation of Alu hypomethylation may clarify the epigenetic regulation of osteoporosis in post-menopausal women.
Further evaluation of genetic data from different populations is needed to understand the genetic role of TMEM230 in PD etiology.
Further evaluation of strategies to address H. pylori infection is warranted.
Further evaluation of the reasons for this disparity and implementation of comprehensive coverage for medical care are urgently needed.
Further evaluations of integrated intervention programs to limit functional decline are therefore required.
Further evaluation using more complex driving environments is needed to assess the real-world implication of this interaction.
Further evidence is needed to assess the efficacy and safety of reduction behavioural support and bupropion.
Further examination adding a category for \ "family of choice \ " is warranted and supported by the originator of the tool.
Further examination of how generational patterns of stress are passed down is warranted.
Further examination showed that Celergen enhanced expression of the p21 ( CIPl1WAF1 ) , GADD153 genes and downregulated the c-myc gene.
Further examinations were made at age @number@ @number@ and @number@
Further experimental and clinical studies are ongoing to confirm the central role of platelets in the development of inflammation and cancer.
Further experiments demonstrated that this effect is caused by a thermolabile factor present in serum of older individuals.
Further experiments showed that 6-OHDA-induced decrease in Ndfip1 levels might be related to proteasomal and lysosomal activations and oxidative stress caused by 6-OHDA.
Further experiments showed that cocaine-induced JNK activation induced up-regulation of cyclin A2 , leading to enhanced proliferation of human astrocytes.
Further exploration about upstream signals indicated the contribution of Akt hypo-activity and FOXO3 to hSKP senescence.
Further exploration involving a larger sample size is recommended to confirm these findings.
Further exploration of GREI and its effects on other psychological variables related to perceived exercise behaviors may substantiate its effectiveness.
Further exploration of the interaction of protein intake and weight loss as related to falls is needed.
Further exploratory analyses indicated significant adverse associations between speed of processing and attention and IL-6 reactivity in the group with low but not high fatigability.
Further , expression of this FR-related encoding-phase network made the largest independent contribution to predicting vulnerability to overall SD-related impairment.
Further extensive longitudinal studies are needed to understand the timing and the possible degenerative characteristics of structural impairment associated with schizophrenia.
Further , failure of these pathways may lead to human disease.
Further , female-specific guidelines have been developed to prevent and reduce CVD in women.
Further , food- or smoking-derived AGE have also been shown to promote the aging-associated organ damage in humans.
Further gender-based subgroup analyses did not find any significant results ( p > 0.05 ) .
Further , gender was examined as a moderator of this association to determine if perceived burdensomeness exerted a greater influence on suicide ideation in males.
Further genetic analyses and functional studies of novel variants are warranted.
Further genetic analysis of subdued mutant and thermo-TRP mutants show that they interact functionally in thermal nociception.
Further genetic analysis showed a novel mutation in the WRN gene which has not previously been reported.
Further , given patient variability in response to initial treatments , stepped care approaches may be beneficial.
Further GLaz-dependent improvement is concealed.
Further , grandmothers with a more individualistic cultural orientation were more intrusive toward their grandchildren.
Further , graphical theoretical analysis using rCMRglcs was applied to examine differences in the functional network properties of the brain.
Further , greater arterial compliance in frontoparietal regions was associated with younger age and higher eCRF.
Further , greater white matter hyperintensity volume was associated with increased activation of a frontal network node independent of chronological age.
Further harmonization of assessment approaches for vascular pathologies is required.
Further , HDAC3 physically interacts with ataxin-7.
Further , health systems must improve integration between primary care and specialist clinicians to ensure the burden is shared efficiently across the system.
Further high-quality RCTs are needed to validate this result.
Further human studies are required to strengthen these observations , and provide novel therapeutic approaches.
Further , ideally large-scale multicentre and register-based studies are needed to clarify the role of key risk factors for the development of ARM.
Further ideas about how social workers can participate in these interprofessional social marketing campaigns are provided.
Further implementation of falls prevention strategies is needed to control the burden of fall-related injuries in the aging population.
Further implications are discussed.
Further improvement can be expected from higher resolution if the loss in SNR is accounted for.
Further improvement in the outcome of patients with mantle cell lymphoma is expected.
Further improvements may be possible because skeletal size and maturity-related biases in agreement were detected.
Further improvements will depend on international , multispecialty efforts to standardize terminology and analyze large numbers of these infrequent adverse events.
Further , in analogy to many other membrane proteins that are subject to RIP , AICD can translocate to the nucleus to regulate transcription.
Further , in both girls and boys alike , children with higher puberty scores were more likely to name children than adults.
Further , increased activation in precentral regions in all older adults indicated a stronger involvement of the task positive network ( TPN ) with age.
Further , increased autophagy and high levels of intracellular amino acids may act to support mTORC1 activity in starvation conditions.
Further , increased connectivity was correlated with poorer performance on a neurocognitive task independently of age.
Further , increased plasma yields of the proinflammatory enzyme myeloperoxidase were also observed.
Further , increasing our understanding of the degenerative process is essential to the development of new therapeutic interventions and the optimization of existing treatment protocols.
Further in-depth investigation into how Runx family genes are involved in stem cell regulation is warranted.
Further , individuals who showed greater coupling between positive and negative modulation performed better on a fluid reasoning task.
Further information and enquiries can be made to [ sagesurvey@who.int ] or the corresponding author.
Further information was collected from respondents in order to analyse the potential effect of a number of variables on cognition.
Further insight into GCH1-associated pathogenetic mechanisms will shed light on the role of dopamine metabolism in nigral degeneration and Parkinson's disease.
Further in support of this regulatory link , depletion of p21 reversed this SETD8-mediated cellular senescence.
Further interrogation with Pathway Analysis placed gait speed as a polygenic complex trait in five major networks.
Further intervention study is required to improve the cognitive health of older adults living in the veterans ' retirement communities.
Further , intracranial tumor growth was inhibited by hUCBSC in athymic nude mice.
Further investigation indicated that Numb depletion impaired autophagic degradation through inhibiting the activities of lysosomal enzymes ( Cathepsin D , β-glucuronidase and β-glucosidase ) .
Further investigation indicated that PI3K and the Gβγ subunit were likely to play an essential role in HCA2-induced Akt activation.
Further investigation in different memory tasks , times , and amnesia models together with more complex control groups might provide further clues.
Further investigation into these associations could aid in understanding the biological pathways underlying both T2DM and depressive symptoms.
Further investigation into yoga as an exercise activity for older adults is warranted.
Further investigation is needed in terms of understanding the risk factors , mechanisms and the most adequate therapy.
Further investigation is needed to clarify the prognostic impact of MetS in older adults.
Further investigation is needed to clarify this potential association.
Further investigation is needed to determine if there is a specific AL signature for pain that differs from other health conditions.
Further investigation is needed to elucidate causes and ways to prevent recurrent falls.
Further investigation is needed to examine the reasons for the disparities between the two sources of information.
Further investigation is required to determine the etiology of these relationships.
Further investigation is required to examine whether not engaging in partnerships will deem an organisation unsustainable in the longer term.
Further investigation is warranted to explore changes in valve morphology in the pediatric population in health and with disease.
Further investigation may lead to improved understanding of underlying mechanisms and could contribute to the identification of treatments for age-related cognitive deficits.
Further investigation of the association between syncope burden , unexplained falls and cognitive decline is required to establish a relationship between these disorders.
Further investigation of the mechanism of RER1 and downstream effectors on αSyn may yield novel therapeutic targets for modulation in Parkinson disease and related synucleinopathies.
Further investigation of these regions may yield other potential biomarkers and help to explain detrimental cellular processes associated with tendon ageing and tendinopathy.
Further investigation of this intervention is warranted to evaluate its preventive potential and mechanisms of action in the context of early neurodegeneration.
Further investigation of this possible locus and other suggestive loci may reveal novel biological pathways that influence healthy aging.
Further investigation revealed that EGb-mediated c-Jun degradation was preceded by ubiquitination of c-Jun and could be prevented by the proteosome inhibitor MG-132.
Further investigation revealed that the observed αsyn accumulation is a result of lysosome dysfunction caused by extracellular ATP-induced elevation of lysosomal pH.
Further investigation revealed that transcription of WWP1 is stimulated by DNA damage in these cells.
Further investigation revealed that TSA can induce the activation of ERK1 / 2 in the three non-cancer cells but not in the cancer cells.
Further investigations are also warranted to fully explore the amniotic cells ' potential for adult human disorders.
Further investigations are needed to ascertain whether better otolith function in blacks might contribute to a lower risk of mobility disability and falls.
Further investigations are needed to clarify the long-term benefits of outpatient GEM services.
Further investigations are needed to corroborate these preliminary findings and determine whether MQC pathways may become target for future interventions.
Further investigations are needed to estimate the relationship between As and bone metabolism.
Further investigations are needed to examine the relationship of oxidative stress as an endogenous bioactive agent to bone loss in post-menopausal women.
Further investigations are required to confirm these findings.
Further investigation should be conducted for such models.
Further investigation should focus on potential roles of endogenous hormones.
Further investigations , including randomized control trials in nondiabetic individuals , are required to demonstrate the nonglycemic effects of metformin.
Further investigations of the biological basis for these associations including randomized trials of T supplementation are needed.
Further investigations using longitudinal data are needed to clarify our findings.
Further investigation will permit a better understanding ofthe mechanisms governing the processes o f aging andthe emergence of variouspathologies associated with oxidative stress.
Further investigation with a larger sample is warranted to verify our initial findings and identify other loci contributing to circulating phylloquinone.
Further in vitro , we established the antiproliferative actions of CNP and the participation of the clearance receptor using adult human cardiac fibroblasts.
Further issues relate to the identification of the genetics determinants of protein energy wasting in elderly.
Further , it assists in the identification of specific technologies that promote active engagement in later life for women and men.
Further , it can be used to study every other neurological and psychiatric disorder.
Further , it enables us to generate new labels that are not present in any delineation protocol by defining intersections on the underling labels.
Further , it has been shown that small , but significant , reductions in postural sway are possible with various balance exercise interventions.
Further , it is found that AGE-α-synuclein induced conformational changes in scDNA from B-form to B-C-A mixed conformation.
Further , it is imperative that leaders engage stakeholders to commit to support the agreed strategies designed to provide efficient and comprehensive healthcare services.
Further , it is possible to find Asc of SBRN by non-invasive US study and calculate the fascicular and non-fascicular area using our histological findings.
Further , it is unclear if adhering to the DASH target nutrients has similar BP impact as adhering to the recommended DASH food groups.
Further , it is unclear why synapses in AD cerebellum are protected from degeneration.
Further large clinical trials are necessary to better identify the clinical role of DHEA supplementation in this population.
Further large multicenter studies sharing the same imaging protocols are needed to develop objective models for risk assessment in these fetuses.
Further , large-scale clinical trials are warranted to confirm these results.
Further , large-scale studies including other races are required to confirm these findings.
Further , late-passage MSCs showed increased expression of p21 ( Cip1 / Waf1 ) ( p21 ) , an inhibitor of the cyclin-dependent kinase.
Further , leveraging key partnerships and existing communication channels can maximize success and facilitate timely translation of research findings into public health practice.
Further longevity studies of long-lived organisms may provide important breakthroughs with human health applications.
Further longitudinal research should explore the development and determinants of perceived control across the full life span.
Further , longitudinal studies are also necessary to understand the predictors and outcomes of social engagement levels among Chinese older adults.
Further longitudinal studies are needed and can inform future interventions to improve metabolic status in older adults.
Further longitudinal studies are needed to confirm this finding.
Further longitudinal studies are needed to confirm this finding.
Further longitudinal studies are warranted.
Further longitudinal studies are warranted to assess inflammation as a potential treatment target for a subgroup of schizophrenia.
Further longitudinal studies should be conducted to better understand risk factors and outcomes associated with anxiety among U.S. Chinese older adults.
Further longitudinal studies should be conducted to explore the risk and protective factors associated with suicidal ideation.
Further longitudinal studies with a range of other strength measures are warranted.
Further measurement of relevant markers in the genome could be a tool in routine screening to predict age of forensic biological samples.
Further mechanism studies using neutralizing antibodies against each growth factor may clarify the role of soluble factors of SHEDs in wound-healing process.
Further , mid-diaphyseal periosteal measures including cambium and fibrous layer thickness and cellularity do not correlate significantly with age or body mass.
Further , mI was higher in C allele carriers of the SCN1A variant rs10930201.
Further , moderation analyses showed that the relationships between cognitive functioning and everyday PM were different for young and older adults.
Further molecular characterisation revealed that SIRT1 interacts in an insulin-independent manner with the PI3K adapter subunit p85.
Furthermore , 11-norbetaenone ( @number@ ) displayed significant anti-angiogenic effect by suppressing tube formation.
Furthermore , 8-Bromo-cGMP reduced TGFβ-dependent collagen release.
Furthermore , a 14-day LED irradiation moderately increased keratinocyte proliferation.
Furthermore , a balance-training program , such as Tai Chi , can improve postural stability and Quality of Life.
Furthermore , a Bayesian statistical framework of analysis provides more useful age estimates.
Furthermore , abnormalities in mitochondrial quality control or defects in mitochondrial dynamics have also been linked to senescence.
Furthermore , about @percent@ of people showed more pronounced fold increase ( 2-fold ) in telomerase activity after the MBT.
Furthermore , a characteristic of aging is the progressive deterioration of immune function known as immunosenescence.
Furthermore , ACHD patients may develop an increasingly negative perception of their illness as they age.
Furthermore , a chemical compound targeting PrxII inhibits the expansion of APC-mutant colorectal cancer cells in vitro and in vivo tumor xenografts.
Furthermore , a comprehensive neuropsychological battery and detailed behavioural assessment , with measures of empathy and awareness , were included.
Furthermore , activated MMP-2 and MMP-1 were increased by NE treatment in a dose-dependent manner.
Furthermore , ADAR1 negatively regulates interaction of Ctn RNA with RNA-destabilizing proteins.
Furthermore , addition of P-NCP to fibroblasts inhibited cell death induced by UVA ( 400-315 nm ) irradiation in a dose-dependent manner.
Furthermore , a decline in mitochondrial health is prevalent with aging.
Furthermore , a decrease in c / a was found to be associated with atherosclerosis-based conditions , such as hypertension , diabetes mellitus and hyperlipidemia.
Furthermore , AD has provided the most positive indication to support the fact that inflammation contributes to neurodegenerative disease.
Furthermore , adiponectin inhibited the mRNA and protein expression of mTOR in β-GP-treated VSMCs in a time- and concentration-dependent manner.
Furthermore , adipose tissue dysfunction indicated by dysregulation of leptin , tumor necrosis factor-α , and adiponectin is associated with poor prognosis in centenarians.
Furthermore , administration time is short and requires no special training or skills.
Furthermore , a dose-response association was observed between the amount and frequency of passive cigarette smoking and the control rate of hypertension.
Furthermore , AD patients showed lower FA in the posterior part of the brain with relatively early-myelinating fiber bundles.
Furthermore , AD patients with low flexibility showed higher similarity of past and future thinking than those with high flexibility.
Furthermore , a dramatic reduction of BACE1 at mRNA and protein levels was observed after galangin treatment.
Furthermore , advanced age is one of the most important risk factors for the development of idiopathic pulmonary fibrosis ( IPF ) .
Furthermore , advances in structural imaging allow for earlier detection of even subtle glaucomatous nerve damage.
Furthermore , aerobic metabolism may continue into adulthood to supply biomolecules for activity-related changes at the synapse and turnover of constituent structural components of neurons.
Furthermore , a fear of falling also contributes to the gait disorder.
Furthermore , affinity histochemistry of pericellular HA was performed.
Furthermore , a formal cost-effectiveness analysis of dabigatran compared to VKAs for DVT treatment was performed , using these estimates.
Furthermore , a freely accessible web server for NOA has been developed at @url@
Furthermore , African American veterans were substantially more likely than Caucasian veterans to have been incarcerated and showed less decline as the cohort aged.
Furthermore , age-dependent decrease of STUB1 correlates with increased NQO1 accumulation.
Furthermore , age differences in TOT incidence occurred only for words with low-frequency first syllables.
Furthermore , aged PDCs were observed to be impaired in their capacity to induce perforin and granzyme in CD8 T cells.
Furthermore , age-induced differences are shown in the topographic maps and the neural activation for both emotional stimuli.
Furthermore , ageing drivers experience more crashes at unchannelized intersections compared to channelized intersections.
Furthermore , ageing reduces the increase in cutaneous endothelial activity in response to LH.
Furthermore , age in itself should not be a contraindication to breast-conserving surgery ( BCS ) because QOL appears somewhat better after conservative surgical treatment.
Furthermore , AGER1 provides protection against AGE-induced ROS generation via NADPH.
Furthermore , age-related changes were identified for indices taken from the photographs.
Furthermore , age-related LV dysfunction has been shown to be one of the main risk factors for future heart failure.
Furthermore , aggressiveness towards people and dogs in different contexts interacted with sex and age.
Furthermore , aging interacts with these factors to influence cognition and dementia risk in late life.
Furthermore , aging is also found to be related to the reduction in mitochondrial function , insulin resistance , and dysregulated intracellular lipid metabolism.
Furthermore , aging is associated with advance shifting of the TSH rhythm , which is a phenomenon also observed in other biological rhythms.
Furthermore , aging may alter T cell-induced MPC function.
Furthermore , aging vastly alters the transcriptional profile and specifically downregulates cell cycling pathways in alveolar macrophages.
Furthermore , a higher body mass index was observed in older patients.
Furthermore , a higher percentage of dropouts was found in the venlafaxine group compared to the sertraline group.
Furthermore , AHI values correlated significantly with neck circumference , GPx activity , and MDA , hs-CRP , and TNF-α concentrations in OSA patients.
Furthermore , aldosterone in the highest tertile correlated with lower NP levels and increased mortality.
Furthermore , all patient groups showed lower posterior alpha @number@ source activities.
Furthermore , a low amount of visual feedback minimizes age-associated differences in variability.
Furthermore , aMCI subjects who employed emotion-focused coping had higher SSL scores ( p = @number@ ) .
Furthermore , a mitochondrially targeted catalase transgene suppresses Bak expression in the cochlea , reduces cochlear cell death , and prevents AHL.
Furthermore , among PD patients , H1 homozygotes have an accelerated progression to dementia.
Furthermore , a mutant of BMI1 with an altered βTrCP recognition motif is much more stable than wild-type BMI1.
Furthermore , amygdala sensitivity was greater for fearful than for happy or sad faces.
Furthermore , an age-related decline of this GP has been reported.
Furthermore , an antibody against PATE1 assay was used to test whether PATE1 participated in sperm motility and penetration of zona-free hamster egg.
Furthermore , an estimated hip strength below @number@ N may represent a critical level of systemic skeletal fragility in both sexes that warrants further investigation.
Furthermore , an increase in stiffness of collagen ( ani ) at high physiological pressure was found.
Furthermore , an increase in TRPV5-mediated Ca ( 2 + ) uptake was detected after galectin-3 treatment.
Furthermore , an induced pluripotent stem cell-derived ARVC / D cardiomyocyte model was used to investigate the effects of sex hormones.
Furthermore , an intraindividual aging effect of @percent@ per year was observed.
Furthermore , an inverse relationship between miR-1 and API-5 expression was observed in human liver cancer tissues and adjacent normal liver tissues.
Furthermore , an inverse relationship between PRL levels and stressful life events or depressive symptoms was observed.
Furthermore , an in vitro assay revealed that the human Grx5 / GSH system efficiently catalyzed the reduction of oxidized hPTEN.
Furthermore , ankle plantar flexion ROM and knee extension strength were significant explanatory variables for the @number@ m gait test and TUGT.
Furthermore , an older age was found to be related to a decreased sensitivity for impulsive buying.
Furthermore , an organic anion transporting polypeptide 2B1 inhibitor suppressed latanoprost acid-mediated klotho shedding ex vivo , whereas an FP receptor antagonist did not.
Furthermore , a novel composite task probed participants ' abilities to infer both cognitive and affective mental states in an interpersonal context.
Furthermore , a novel neuropreservation effect of AGE was detected in that pre-treatment with AGE alone protected ∼ @percent@ neuronal cells from ROS-mediated damage.
Furthermore , anterior SMA responses in the elder group may only have a positive correlation with the VFT performance.
Furthermore , anti-cancer drugs aimed at some of these targets have been already developed.
Furthermore , an updated meta-analysis should include eleven new randomised trials on treadmill training after @number@
Furthermore , APO10LA suppressed Akt activation , cyclin D1 gene , and protein expression and promoted PARP protein cleavage in transformed cells within liver tumors.
Furthermore , apoE4 expression increased whereas apoE3 reduced amyloid-related gliosis in the mouse brains.
Furthermore , APOE ε4 carriers who did not exercise had a higher risk of incident MCI than noncarriers who reported physical activity.
Furthermore , a potentially modifiable variable , late-life social engagement is associated with a decreased mortality risk in all of the population sub-groups.
Furthermore , a profound body of evidence revealed that the cooperative function of RECQLs and PARP1 represents an important factor for maintaining genome integrity.
Furthermore , a recent clinical trial has validated the feasibility of targeting GSK-3 with small molecule inhibitors for human diseases.
Furthermore , a recent epidemiological study reported that iron reduction by phlebotomy was associated with decreased cancer risks in a general population.
Furthermore , a recent review suggesting that short-term paracetamol use is ineffective for osteoarthritis has added to the confusion.
Furthermore , a reduction in the frequency of abnormal nuclear morphology and DNA double-strand breaks was observed along with decreased ROS levels.
Furthermore , a relationship between crowding and other physical characteristics of the environment was found.
Furthermore , arrhythmias indicative of arrhythmogenic right ventricular dysplasia were not observed in the study group.
Furthermore , ART sensitized breast cancer cells to the chemotherapeutic agent epirubicin through an autophagy-dependent cascade.
Furthermore , a safe deduction is that treatments that extend lifespan do so by reducing age-related pathology , both florid and subtle.
Furthermore , ASCs displayed more pronounced adipogenic differentiation capability relative to BMSC based on Oil Red staining ( 7-fold vs. @number@.85-fold induction ) .
Furthermore , a selection of common textbooks was used to fill in gaps in physiology data or understanding not covered by the journal articles found.
Furthermore , as hESCs differentiated a progressive decrease in the accuracy of NHEJ was observed.
Furthermore , a significant correlation was observed between LTC and TTC in both groups , regardless of the condition or obstacle height.
Furthermore , as muscle weakness may reflect a global effect of aging , we further investigated whether tongue strength is correlated with handgrip strength.
Furthermore , as observed in PMCA , plasminogen and kringles promoted PrP ( Sc ) propagation in ScN2a and Elk 21 ( + ) cells.
Furthermore , aspirin combined with TMZ enhanced chemosensitivity and GLI1-induced chemoprotection was partly blocked by aspirin
Furthermore , assessment of hippocampal connections may help in understanding the cerebral organization and remodeling associated with treatment response.
Furthermore , as the regulation of emotions changes during the life span , age may affect pain catastrophizing , as well.
Furthermore , a tendency for increased jump power ( @percent@ , p = @number@ ) was observed.
Furthermore , athletes with larger arm spans and shorter legs were particularly adept at finding energetic savings.
Furthermore , a TIME × GROUP interaction analysis revealed time-dependent gray matter changes in the right cerebellum.
Furthermore , at low difficulty levels , decreases in BOLD response were found after WM training.
Furthermore , atomic force microscopy revealed that Lamin A / C knockdown decreased cellular stiffness in the lamellar region.
Furthermore , ATO promoted adipogenic differentiation , but inhibited osteogenic differentiation in MSCs.
Furthermore , at the molecular level , this depletion was associated with reduced levels of the postsynaptic protein PSD-95 but not the presynaptic protein synaptophysin.
Furthermore , augmentation occurs almost exclusively during treatment with dopaminergic drugs.
Furthermore , average resorption pit area , resorption pit density , and percent resorption area were found to decrease significantly with age.
Furthermore , axin @number@ and β-catenin mRNA were significantly higher in older females than older males ( p < @number@ ) .
Furthermore , Aβ-O caused intraneuronal dislocation of β-catenin protein and a reduction in its levels , and these alterations were partially reversed upon Aβ-O withdrawal.
Furthermore , baseline exercise self-efficacy was correlated with exercise volume executed by subjects at home.
Furthermore , baseline startle decreased over the course of puberty.
Furthermore , because our recent knowledge on hormonal action expanded significantly , downstream pathways and genetic determinants currently prevail in aging research.
Furthermore , before and after the treatment , clinical evaluations and self-assessment questionnaire were done.
Furthermore , besides p53 , PUMA transactivation was also regulated by forkhead box O3a through p53-independent manner following Aβ treatment.
Furthermore , BET was able to increase significantly both SOD2 gene expression and protein content.
Furthermore , between @percent@ and @percent@ of daily nutrients were provided at home.
Furthermore , blink reflex characteristics such as habituation did not differ between patients and controls.
Furthermore , BMI change is not significantly associated with HF risk after adjusting for CRF changes.
Furthermore , BNP and ANP levels were reduced to normal , suggesting the absence of cardiac dysfunction.
Furthermore , body composition and muscle strength was measured.
Furthermore , both hTERT and hTERT K626A interacted with NF-κB p65 and increased NF-κB p65 nuclear accumulation and DNA binding.
Furthermore , both master athletes and young athletes displayed a thicker patellar tendon.
Furthermore , both the R. rosea extract and salidroside treatment of UMUC3 cells caused a significant percentage of cells undergoing autophagy.
Furthermore , both tumor DNA and DNA from a metastasis are analyzed regarding this mutation.
Furthermore , brief tests of VSM that are appropriate for screening have not been standardized.
Furthermore , broad-spectrum antibiotic therapies are sometimes given until microbiological results are available and de-escalation cannot be performed quickly.
Furthermore , by combining computational modeling and the BiLC reporter assay , we identified several novel small-molecule compounds that selectively inhibited PB1-PB2 interaction.
Furthermore , by disrupting the CD47-SHPS-1 association , we found that osteoclastogenesis was markedly impaired.
Furthermore , caregivers ' trajectories of functional limitation were associated with their extent of ADS use at baseline and their relatives ' placement.
Furthermore , caveolin-1 expression levels inversely correlate with the abundance of GATA-6 in BSM hypertrophy in mice and human beings.
Furthermore , CAVI was associated with SMI even after adjustments ( OR @number@ @percent@ CI @number@ @date@ , P = @number@ ) .
Furthermore , CB1R activation impedes insulin-stimulated IR autophosphorylation on β-cells in a Gα ( i ) -dependent manner.
Furthermore , CD2AP gene expression in peripheral blood lymphocytes ( PBL ) from @number@ SAD patients and @number@ controls was determined.
Furthermore , central injection of PP in mice induced c-Fos immunoreactivity in somatostatin-containing cells in the hippocampus compared with PBS-injected mice.
Furthermore , changes during normal aging were studied.
Furthermore , children as old as age @number@ years old showed slower rates of adaptation and de-adaptation of spatial parameters of walking.
Furthermore , clinical trials to treat aging are impractical.
Furthermore , cognitive functioning predicts performance in the young , but not in the older adults.
Furthermore , cognitively normal individuals especially from ADNI and AIBL are not representative of the general population.
Furthermore , cognitive performance was positively associated with contrast sensitivity.
Furthermore , collagen fiber types also demonstrated a statistically significant alteration with age ; increases in age resulted in decreases in larger collagen fibers.
Furthermore , co-localization experiments by fluorescent confocal microscopy revealed that FAM96B colocalized with prelamin A in HEK-293 cells.
Furthermore , combination treatment with the autophagy inhibitor bafilomycin A1 enhanced the induction of apoptosis by KY17.
Furthermore , comorbidity , in particular that measured by the LCRI , is an important independent indicator of cancer survival.
Furthermore , comparative data on reproductive senescence from other primates , or indeed other mammals , remains relatively rare.
Furthermore , compromised autophagy also leads to muscle atrophy.
Furthermore , concern about ED increased with age , peaking in the 50-59 years age band , but decreased thereafter.
Furthermore , conducting studies in highly selected , younger , healthier individuals to provide ' proof of concept ' information is now common.
Furthermore , considerable rate of newly-diagnosed diabetes signifies the importance of the screening programme.
Furthermore , considering the principles of hifz-al-sehah can help secure long and healthy lives for the elderly.
Furthermore , constituents of functional assemblies can aggregate and become non-functional during aging.
Furthermore , correlation between increases in serum IL-6 and MMP-9 concentrations may suggest that IL-6 could exert modulatory effects on MMP-9 release during maximal exercise.
Furthermore , cortical thickness in the brain regions defined by these networks was reduced in MCI.
Furthermore , countries adopt vastly different policies.
Furthermore , CR improved the number of implantation sites in pregnant mice despite RU injection.
Furthermore , cultivation of middle passage normal human skin fibroblasts in the presence of CS ameliorated the physiological state of cells during replicative senescence.
Furthermore , culture medium containing @percent@ of such serum both increased osteoblastogenesis and reduced adipogenesis in human MSC from bone marrow.
Furthermore , cytokine profiles might be modified with aging , with some investigators suggesting a trend toward T ( H ) 2 cytokine expression.
Furthermore , cytokine secretion ( IL-1β , IL-6 , IL-8 ) appears to be maintained for an extended period of infection.
Furthermore , cytological dysplasia and molecular alterations were more frequently detected in elderly patients with SSAs than in non-elderly patients.
Furthermore , cytosolic and mitochondrial Ca ( 2 + ) levels were simultaneously measured in TRPC1-silenced Huh7 hepatocellular carcinoma cells.
Furthermore , DAC treatment induced cellular senescence and autophagy as shown by β-galactosidase staining and by autophagosome formation , respectively.
Furthermore , data on sales of osteoporosis treatments and the population at high risk of fracture were used to estimate treatment uptake and treatment gap.
Furthermore , data revealed that the cognitive abilities predicting one's task performance varied according to the complexity of the task.
Furthermore , D-dimer , troponin T , and high-sensitive troponin T levels had limited predictive value for PE in the very elderly.
Furthermore , decreased IL-1 receptor antagonist ( IL-1RA ) levels and a lower IL-1RA / IL-1α ratio were found following repeated exposure to the irritants.
Furthermore , delphinidins decrease platelet activity and may contribute to thrombosis prevention.
Furthermore , delphinidins increase endothelial nitric oxide synthase expression and decreases expression of vaso-constrictory endothelin-1.
Furthermore , depletion of DDX39 induced DNA-damage response foci at internal genome as well as telomeres as evidenced by telomere dysfunction-induced foci.
Furthermore , depression , behavioral changes , and cognitive impairment commonly complicate therapy and make assessment more difficult.
Furthermore , despite maintaining the ability to bind and phagocytose bacteria , MDMs from these individuals have a reduced capacity to kill S. pneumoniae.
Furthermore , developmental aging plays a crucial role in the progression of these abnormal cellular phenotypes.
Furthermore DHJST also showed a trend towards promoting the same effects in the same system.
Furthermore , dietary restriction ( DR ) that leads to antagonistic changes in growth and lifespan , also mediates this change by inhibiting protein synthesis.
Furthermore , dietary total and cereal fibre were significantly inversely associated with knee pain worsening in OAI ( p trend < 0.02 ) .
Furthermore , differences in the amount of hydrogen peroxide ( H2O2 ) produced by S. sanguinis isolated from both groups were assessed.
Furthermore , digitized morphologies enable computational modeling of biophysically realistic neuronal dynamics.
Furthermore , disruption in melatonin production and circadian rhythmicity has been associated with aging.
Furthermore , distances during these phases correlated inversely with OLS time.
Furthermore , disturbances in peroxisomal redox balance , although not necessarily correlated with the age of the organelle , may trigger its degradation.
Furthermore , during ageing , Notch activity decreases which results in decreased muscle regeneration.
Furthermore , early intensive monitoring , aggressive resuscitation , and time of surgical intervention are of upmost importance to reduce mortality.
Furthermore , EC facilitated re-entrainment of behavioral rhythm in mice when phase of the light-dark cycle was suddenly advanced.
Furthermore , ED and low testosterone are markers of poor health which impact on an individual's self-perception of their health status.
Furthermore , education , marital status , and number of children were significantly associated with chronic smoking behavior.
Furthermore , education modified the relationship of lacunar infarcts with cognitive abilities ( p = @number@ ) .
Furthermore , elevated sodium promoted lipid accumulation in cultured adipocytes , suggesting direct causative effects on lipid metabolism.
Furthermore , end-of-life decisions are complicated by consideration of device deactivation in patients who may not die immediately from an otherwise lethal pathophysiology.
Furthermore , entorhinal and hippocampal hemispheric asymmetry could be modified by pathology during Alzheimer's disease development.
Furthermore , epidemiological studies suggest that IGFBP-3 and the molar IGF-I to IGFBP-3 ratio are associated with clinical end points like cancer or cardiovascular disease.
Furthermore , Eruca sativa Mill. aqueous extract inhibited NF-κB activation.
Furthermore , event-related neural processing showed intact crossmodal integration in higher performing older adults similar to younger adults.
Furthermore , excessively short telomeres are prone to create telomeric fusions , causing genomic instability and malignant transformation.
Furthermore , excess sFRP1 in elderly patients causes CSC aging.
Furthermore , Exo70 influences the splicing of a model substrate as well as of its own pre-mRNA in vivo.
Furthermore , experimental studies have demonstrated the direct action of androgen on the vasculature.
Furthermore , expression array analysis reveals that many loci , including noncoding RNAs , may be regulated by telomere length.
Furthermore , expression of MSC markers and markers associated with stress or aging remained unchanged.
Furthermore , family socioeconomic status ( SES ) predicted change in rule-guided behavior , such that higher SES predicted better performance with development.
Furthermore , fat mass and extracellular water levels were significantly higher in the patients compared to the controls ( p < @number@ ) .
Furthermore , fibroblast to myofibroblast transformation could be enhanced by ECM glycation.
Furthermore , findings on the mechanism of radical genesis , proteasomal inhibition and the required components of lipofuscin formation were resumed.
Furthermore , five-year olds performed better than three- and four-year olds in the task.
Furthermore , foods that are often high in sugar , such as processed foods , are typically lacking in nutrient quality.
Furthermore , for any task pairing , behavioral and topographic similarities of underlying activation patterns are strongly linked.
Furthermore , forced overexpression of wild-type TFAM in RKO cells carrying a TFAM truncating mutation suppressed cell proliferation and inhibited RKO cell-induced xenograft tumor growth.
Furthermore , for some domains , variability was larger for older participants ; this was attributable to increases in environmental components.
Furthermore , free radicals exposure reduced ACO2 activity more in individuals with AD than in OCN subjects.
Furthermore , FS intake of the U18s was significantly lower than the U13 / 14s and U15 / 16s ( P < @number@ ) .
Furthermore , fusion of these modalities provides the most plentiful information and the highest predictive accuracy of @percent@.
Furthermore , FXR promotes liver repair after injury and activation of FXR is able to alleviate age-related defective liver regeneration.
Furthermore , gain of MKP-7 function mimicked the effect of rosiglitazone on LPS-induced destabilization and ubiquitination of SIRT1.
Furthermore , gastroenterology training programs do not routinely incorporate elderly concerns when dealing with common gastrointestinal issues.
Furthermore , GDR was significantly correlated with the mean age of death of the parents.
Furthermore , gelsolin enhanced cofilin dephosphorylation in neuregulin-stimulated cells.
Furthermore , gene silence of klotho markedly attenuated the anti-senescence effect of CGRP on EPCs.
Furthermore , genome sequencing of mortalin from Parkinson disease patients identified two missense mutants , R126W and P509S.
Furthermore , gephyrin pamitoylation potentiated GABAergic synaptic transmission , as evidenced by an increased amplitude of miniature inhibitory postsynaptic currents.
Furthermore , germ cell epigenetic changes might be inherited by the next generations.
Furthermore , ghrelin is associated with metabolic and cardiovascular health , and may have anti-aging effects , but these effects may be attenuated in obesity.
Furthermore , global changes in chromatin conformation and nuclear organization have also been proposed as potential contributors to aberrant DNA methylation.
Furthermore , greater activity in the left anterior hippocampus and left IFG was observed during intentional associative compared with item encoding.
Furthermore , greater arterial stiffness is a common characteristic of women who develop hypertensive complications of pregnancy.
Furthermore grip strength varied widely between healthcare settings independent of known major influences.
Furthermore , grouping together diseases that share similar age patterns in mice resulted in clusters that mirror actual biomedical knowledge.
Furthermore , growth parameters of subjective organization turned out to be reliable predictors of verbal learning.
Furthermore , GVI was associated with mobility function , including walking speed and performance on the Berg Balance Scale.
Furthermore , hADSCs showed reduced efficacy in aged rats , which may in part result from decreased homing of the cells to the spleen.
Furthermore , hand searches were conducted.
Furthermore , having a pain-related diagnosis was associated with use of psychotropics in persons with dementia.
Furthermore , HCH6-1 prevented pulmonary neutrophil infiltration and edema along with alveolar damage in LPS-induced ALI in mice.
Furthermore , HCM pathology is independent of protein domain disruption in both MYBPC3 and MYH7.
Furthermore , HCMV infection might be considered as the most important factor for driving immune senescence in the elderly.
Furthermore , HDAC6-selective inhibition or HDAC6 knockdown induced ribosomal protein acetylation.
Furthermore , health care cost increases are caused by unnecessary operational inefficiency associated with the direct medical service delivery process.
Furthermore , healthy dietary patterns , such as the Mediterranean diet , have been linked to the frailty prevention.
Furthermore , hemispheric asymmetries and potential age-related changes in regional thalamocortical connections were assessed.
Furthermore , hemodynamic responses assessed using non-invasive NIRS could be a useful biological marker of these characteristics.
Furthermore , he recovered from hematochezia , and his hypersensitive C reactive protein decreased.
Furthermore , HET effectively suppresses procoagulant MDMP formation and monocyte-mediated TG under severe hypoxic stress , compared with NET.
Furthermore , heterochromatin formation in senescence appears to contrast with loss of heterochromatin in Hutchinson-Gilford progeria.
Furthermore , higher GluR2 immunoreactivity was associated with milder cognitive impairment and lower concentrations of Aβ42 peptide and phosphorylated tau.
Furthermore , high-quality randomized control trials are required.
Furthermore , high-risk older adults were unable to generate adjustments with the same magnitude and consistency as low-risk older adults and young adults.
Furthermore , histologically , flies expressing hTDP-43 M337V showed global , robust neuronal staining for phospho-TDP.
Furthermore , HIV-associated neurocognitive disorders represent important consequences of the infection.
Furthermore , H₂O₂ accumulation was also suppressed by U0126 , a MEK / ERK inhibitor , in a concentration-dependent manner.
Furthermore , how older adults communicate about and cope with these challenges was examined.
Furthermore , HPLs from older donors increased activity of senescence-associated beta-galactosidase ( SA-βgal ) .
Furthermore , HS-1793 showed more potent anticancer effects in several aspects compared to resveratrol in MCF-7 and MDA-MB-231 cells.
Furthermore , HS-1793 showed more potent anticancer effects in several aspects than resveratrol in HCT116 cells.
Furthermore , HS-1793 substantially induced HIF-1α protein degradation through the proteasome pathway.
Furthermore , human and mouse neuroblastoma cells treated with the amyloid-β ( 1-42 ) peptide also showed a similarly higher expression of miR-455-3p.
Furthermore , human CCO activity was decreased gradually with aging.
Furthermore , Hu-Yi-Neng dose-dependently suppressed the elevation of intracellular reactive oxygen species ( ROS ) level.
Furthermore , hybrid training decreased fasting blood glucose and serum IL-6 levels in elderly people.
Furthermore , hyperglycemia per se does not affect renal Klotho production.
Furthermore , hypoxia initiates a shift of ROR1-positive melanomas to a more invasive , ROR2-positive phenotype.
Furthermore , if incentive disappears , one's intention hardly arises and toilet activities further collapse.
Furthermore I hypothesize that both conditions are restricted to the glabrous palmar skin because of unique anatomical characteristics.
Furthermore , impaired corneal epithelial wound healing may also imply more widespread disease.
Furthermore , inactivating mutations in the miRNA coding regions could be associated with the pathogenesis of osteoporosis.
Furthermore , in an analysis for interaction circulating oxLDL amplified the effect of GGT on all-cause mortality ( P = @number@ ) .
Furthermore , in both young and old participants the assumed light source direction and the lateralized bias in a line bisection task were correlated.
Furthermore , in cardiac patients , plasma CoQ10 has been found to be an independent predictor of mortality.
Furthermore , incidences when registration rates varied between @number@ and @percent@ were calculated.
Furthermore , increased TH homo-specific activity leading to an increase in DA may cause toxic reactive oxygen species in the neurons to promote neurodegeneration.
Furthermore , increase in IL-6 correlated with the increase in MMP-9 concentrations ( P < @number@ R = @number@ ) .
Furthermore , increases in motivation to perform the prospective task seem to help remedy prospective memory deficits in young adults in the naturalistic setting.
Furthermore , increases in the amount of TMEM106B resulted in increases in abnormal lysosomal phenotypes and cell toxicity in both immortalized cell lines and neurons.
Furthermore , increasing satisfaction with the training program over time led to greater job satisfaction and a desire for additional education.
Furthermore , incubation with recombinant CatS significantly reduced the synaptic activity of the cortical neurons.
Furthermore , in-depth proteomic profile of human glomerular sclerosis remains limited.
Furthermore , individualized approaches to care appear to be essential , because concrete ideas about informal caregiving differ strongly despite shared values.
Furthermore , individuals characterized by insecure attachment show more behavioral and psychological problems in dementia.
Furthermore , individuals with higher WM performance showed greater change in connectivity between left dorsolateral prefrontal cortex and left premotor cortex across load.
Furthermore , induction of ISGs in cultured astrocytes was highly sensitive to IFN , especially Type I IFN.
Furthermore , in elder participants one brain region emerged in both contrasts , namely the left ventromedial prefrontal cortex.
Furthermore , information about protection against ultraviolet A radiation , associated with early aging and skin cancer , was to be clarified.
Furthermore , in healthy controls , there was a significant correlation of memory performance and the activation of the left medial and lateral temporal lobe.
Furthermore , in heterozygous AD subjects , relative expression of the protective allele of V4-MS4A6A transcripts was lower ( p < @number@ ) .
Furthermore , inhibition of cofilin phosphorylation in response to CF was prevented by α ( v ) β ( @number@ ) -blocking antibodies.
Furthermore , inhibition of cyclin D1 / Cdk4 by Cdk4-I was sufficient for abolishing radioresistance.
Furthermore , inhibition of glycation products at all the stages of glycation was also studied.
Furthermore , inhibition of the PKA and MAPK pathways , but not inhibition of the PI3K pathway , significantly attenuated the OXM neuroprotective actions.
Furthermore , in human blood cells , IL-10 was slightly elevated indicating polarisation towards a regulatory T cell phenotype.
Furthermore , in inflammation-induced neurodegeneration the cathepsins expressed in activated microglia play a pivotal role in neuronal death.
Furthermore , in LASA-I , these individuals had lower BMD at the hip and lumbar spine.
Furthermore ; iNOS and HO-1 expression and cytokines plasma levels were significantly higher in patients with ACHF as compared to controls group.
Furthermore , in response to ND , YAP increased the autolysosome degradation , thereby enhancing the cellular autophagic flux in breast cancer cells.
Furthermore , in response to the visual interference of the flanker task , speed instructions in particular increased APA errors more than other instructions.
Furthermore , insulin and HbA1c levels were significantly more reduced in the intervention group compared to controls ( both P < .05 ) .
Furthermore , insulin resistance and the prevalence of type @number@ diabetes are known to increase with aging.
Furthermore , intelligibility of dual-rate gated sentences was higher than single-rate gated sentences with the same proportion of retained speech.
Furthermore , interfering this signaling pathway by knocking down RFX1 significantly improved Aβ uptake in BV2 cells.
Furthermore , interventions aimed at preventing hypertension may want to focus on intrapersonal level factors.
Furthermore , in the temporal domain , the minimal silent gap thresholds to Gaussian noises were significantly longer in aged rats.
Furthermore , intra- and interobserver variability were calculated using data from a large volunteer group.
Furthermore , investigators have found adequate repletion and increased intakes of vitamin D to be associated with reduced all-cause mortality rates.
Furthermore , in vitro and in vivo studies report elevated expression and activation of CASP3 in models of AD.
Furthermore , in vitro studies showed that preincubation of recombinant α-syn with 1H7 and 5C1 prevented CT cleavage of α-syn.
Furthermore , in vivo protective effects of GN against hepatic steatosis were assessed in high-fat diet ( HFD ) -induced obese mice.
Furthermore , in vivo study using a mifepristone-induced implantation failure model showed that BA definitely improves the numbers of implantation embryos.
Furthermore , irradiation induces hippocampal neuronal loss in CA1 and CA3 areas , neuroinflammation and reduces gliogenesis.
Furthermore , issues related to organisational difficulties and overcoming language barriers in the intervention impacted on the potential of involving professionals with ethnic minority backgrounds.
Furthermore , it can lead to decreased efficacy of vaccination.
Furthermore , it causes significant emotional trauma to the patients and their families.
Furthermore , it demonstrates the potential of such automated robotic tools as a rapid and quantitative assessment to be used in research and clinical settings.
Furthermore , it discusses the use of theory to help organize reviews of complex interventions.
Furthermore , it had a significantly lower 1-year institutionalization rate.
Furthermore , it has also been suggested that endocytic pathway abnormality of neurons is involved in the formation of the ganglioside clusters.
Furthermore , it has been demonstrated that increased muscle mass due to creatine supplementation can result in increased local bone density.
Furthermore , it has been established that E6AP has a role in numerous diseases including cancers and neurological syndromes.
Furthermore , it has been increasingly demonstrated that a long preclinical course precedes AD.
Furthermore , it is clarified that the protective effect of IL-4 @number@ is independent from APOE protective genotypes.
Furthermore , it is evident that Msrs are involved in methionine metabolism and regulation of the trans-sulfuration pathway.
Furthermore , it is important to document the participation of Black older adults in our earliest and continuing research efforts.
Furthermore , it is known that epigenetic mechanisms are involved in the development of cancer.
Furthermore , it is readjusted by deubiquitination via deubiquitinating enzymes ( DUBs ) that can eliminate ubiquitin from p53.
Furthermore , it is well known that aging is a relevant risk variable for infectious diseases.
Furthermore , it might help to initiate their contact to the modern technology.
Furthermore , it seems that not all of the rules known from basic motor tasks can be generalized to activities of daily living.
Furthermore , its specificity is increased using several markers simultaneously.
Furthermore , it suggests that RPIA can be a good prognosis biomarker and a potential target for HCC therapy.
Furthermore , it was found that the cultured cells recovered their ability to grow when the substrate was reused every passage.
Furthermore , it was observed that the AoA effect is much greater for G.J. than for age-matched control participants.
Furthermore , K36 elevated collagen synthesis in skin fibroblasts by inhibiting UVB-induced Smad7 overexpression.
Furthermore , knockdown of CCN1 significantly reduces induction of IL-1β by UV irradiation , and thereby partially prevents collagen loss.
Furthermore , knockdown of MLL1 downregulated the hypoxia-induced HOTAIR expression , indicating key roles of MLL1 in hypoxia-induced HOTAIR expression.
Furthermore , knowledge being related to attitude and behavior should also be measured complementing the OPACS-US.
Furthermore , large-scale studies are warranted to explore the social and structural barriers which constrain community participation among the elderly population.
Furthermore , LBPs protect against neuronal injury and loss induced by β-amyloid peptide , glutamate excitotoxicity , ischemic / reperfusion , and other neurotoxic insults.
Furthermore , leukotriene modifiers provide additional benefit when added to regular maintenance therapy , not differently from young asthmatics.
Furthermore , LF / HF was significantly decreased in long-term care elderly compared with control elderly after adjustment for covariates.
Furthermore , liraglutide treatment discontinued and ursodeoxycholic acid ( UDCA ) was started to treat cholelithiasis.
Furthermore , little is known about biomarkers of aging and BA score ( BAS ) for healthy people in China.
Furthermore , longitudinal studies are recommended to deepen insight into the development of care dependency and nursing care problems in dementia residents.
Furthermore , long-standing rotator cuff tears did not appear to influence the deltoid shape , i.e. did not lead to muscle atrophy.
Furthermore , long-term outcome remains poor and there is much debate on whether to operate or not in elderly patients.
Furthermore , lower performance in working memory ( WM ) was associated with higher RSFC in the left frontoparietal RS network.
Furthermore , LPS-induced beta1 integrin expression and cellular attachment through an NF-kappaB-dependent mechanism.
Furthermore , macrophages from aged mice and normal human elderly volunteers displayed heightened TNF and IL-6 production upon in vitro stimulation.
Furthermore , MAF14001 might directly interact with Aβ to prevent its aggregation process , a key process on Aβ-induced oxidative stress.
Furthermore , manipulation of metabolic pathways through key signaling components extends lifespan , bolsters proteostasis networks , and delays the onset of proteotoxicity.
Furthermore , many aging-related disorders are associated with inflammation.
Furthermore , many articles report intrahemispheric alteration in functional networks.
Furthermore , many cellular and animal models have proven their value to decipher pathways involved in PD development.
Furthermore , many subjects showed heteroplasmy due to mutations different from the C150T transition.
Furthermore , married grandmothers experienced less caregiving strain , and their age did not insulate them from the strain associated with the level of care.
Furthermore , maximal step-up height correlated to training intensity at follow-up.
Furthermore , MDMX ablation leads to significant retardation of xenograft tumor growth , concomitant with RB accumulation.
Furthermore , MD was significantly associated with hippocampal volume , indicating that white matter pathology is not completely independent of gray matter pathology.
Furthermore , mean connectivity of this network correlated positively with performance across both the multi-domain and the visuomotor group.
Furthermore , measurement and statistically accounting for drift may prove important for better characterizing the effects of tDCS on the human brain and behavior.
Furthermore , mechanical cushioning properties of shoes were evaluated before and after in-vivo aging.
Furthermore , mechanically mixed pigmented specimens showed lower ΔE ( p < @number@ ) .
Furthermore , mediation analysis revealed that connectivity strength regulates the effects of APOE genotype and age on cognitive function in amnestic mild cognitive impairment patients.
Furthermore , medication interference upon telomere length was not controlled.
Furthermore , memory declines during the preclinical stage of AD , when it is clinically indistinguishable from normal aging.
Furthermore , metabolic flux switching via glutamine stimulation induces SIRT4 lipoamidase activity to inhibit PDH , highlighting SIRT4 as a guardian of cellular metabolism.
Furthermore , metabolic risk was associated with the relative amount of time allocated to @number@ of these profiles.
Furthermore metformin seems to decrease cancer risk in diabetic patients.
Furthermore , methodological and linguistic problems in DA research are considered.
Furthermore , MHY2013 markedly increased serum levels of insulin-sensitizing hormones including fibroblast growth factor @number@ ( FGF21 ) and adiponectin.
Furthermore , MHY336 treatment induced similar levels of cytotoxicity compared to doxorubicin treatment ( IC ( @number@ ) = 1.55 μM ) in LNCap cells.
Furthermore , mice treated with anthocyanins-supplemented showed better balance of redox systems ( SOD , GSH-PX , and MDA ) in all age tests.
Furthermore , microbial diversity did not change significantly with advancing age.
Furthermore , migration in response to a chemokine ligand , CCL19 , was equivalent in both age groups.
Furthermore , miR-34a downregulates 53BP1 and inhibits its recruitment to the sites of DNA double-strand breaks.
Furthermore , miR-34a ectopic expression induced pro-inflammatory senescence-associated secretory phenotype molecules.
Furthermore , mitogen-activated protein kinase and C-Jun N-terminal kinase inhibitors inhibited SBGE-induced cell death.
Furthermore , moderate and positive correlations were observed between resilience and self-esteem , because as one increased , the other also increased.
Furthermore , modifications of the body oscillations were observed after OMS.
Furthermore , more evaluation is required to obtain evidence to support financial feasibility and sustainability.
Furthermore , more severe symptoms on arrival and worse functional outcomes were observed with increasing age.
Furthermore , more than @percent@ of all cases ( @number@ cases ) , were record just in one year in @number@
Furthermore , most of these same neurons contain CGRP , the release of which is inhibited by oxytocin.
Furthermore , movement velocity is also a critical component of functional task performance with aging and may contribute to functional deficits.
Furthermore , mRNA expression of lipases was significantly decreased in the SCAAT of FDR subjects.
Furthermore , mRNA expression of selected genes was measured in muscle biopsies ( @number@ h and @number@ days post-exercise ) by real-time reverse transcriptase PCR.
Furthermore , multigroup analyses tested the convergence of the mediational models in the community-dwelling elderly individuals and the residential elderly individuals.
Furthermore , multiple LPO biomarkers are elevated in readily accessible biological fluids throughout disease progression.
Furthermore , multiple variants in PON influence serum paraoxonase activity and their effects may be synergistic.
Furthermore , muscle cells were shown to take up and actively synthesize hormones.
Furthermore , mutant but not normal Atxn1 impaired the dynamics of RpA1 in the nucleus after DNA damage.
Furthermore , mutation at Arg-96 abrogated the cofilin-phosphatase activity of SSH1 in the presence of F-actin.
Furthermore , natural variants within these genes turned out to have an influence on bone mineral density in the general population.
Furthermore , NBP upregulated the vesicular monoamine transporter @number@ gene expression in vitro and in vivo.
Furthermore , neurodegeneration associated with these combined genetic and environmental risk factors could be attenuated by systemic treatment with the bioavailable antioxidant compound EUK-189.
Furthermore , neutrophils from aged TNF-deficient mice expressed CD11b similar to young counterparts.
Furthermore , new developments in treatment devices enhance efficacy while decreasing patient discomfort.
Furthermore , new perspectives recently appeared with the genomic approach.
Furthermore , NMDARs also interact with amyloid beta peptide / amyloid precursor protein and tau protein , whose production represents the main manifestations of AD.
Furthermore , NOACs , especially dabigatran , are not as well tolerated as warfarin in patients with gastrointestinal diseases.
Furthermore , no comprehensive analysis of socioeconomic differences in cancer survival in Germany has been conducted.
Furthermore , no comprehensive analysis on the critical components of this methodology has been previously conducted.
Furthermore , no differences between normal and patient-derived cells were observed regarding their sensitivity to a supra-physiological cortisol concentration.
Furthermore , no differences were found between the two groups regarding the magnitude of the effects , although control participants responded significantly faster than patients.
Furthermore , non-statin therapies have been de-emphasized in recent clinical practice guidelines and remain understudied in the older adult population.
Furthermore , no participants mentioned depression as a reason for attempted or completed suicide among older people despite depression being a well-known suicide-risk factor.
Furthermore , normalization of the fatigue results to the first contraction yielded a similar result ( P < @number@ ) .
Furthermore , no significant main effects of age on the mean accuracy rate under condition of restricted visual feedback were found.
Furthermore , @number@ increased the expression of heat shock protein @number@ ( HSP70 ) , a downstream molecular chaperone of HSF-1.
Furthermore , @number@ increased the expressions of COL1A1 , COL3A1 , and TGF-β1 in vivo and in a cell culture system.
Furthermore , @number@ neuroasymptomatic patients were analyzed before and after treatment initiation.
Furthermore , @number@ of them were rated as top priority for research.
Furthermore , @number@ respondents aged ≥60 years completed the questionnaire , of which @percent@ reported good SRH.
Furthermore , @number@ weeks of hMSC treatment significantly reduced cerebral Aβ plaques and neuroinflammation in APPPS1 mice , without increasing cerebral amyloid angiopathy or microhemorrhages.
Furthermore , @number@ wk resistance training in older adults reduced the age-associated elevation in serum C1q levels.
Furthermore , numerous studies showed that total serum testosterone levels were inversely related to the atherosclerosis disease incidence in postmenopausal women.
Furthermore , O2C measurement was performed to assess improved microcirculation.
Furthermore , OHDHA enhanced the survival of neuron-like differentiated cells exposed to different insults , such as oligomeric Aβ and NMDA-mediated neurotoxicity.
Furthermore , older adults active in personal leisure activities are more drawn to be potential volunteers.
Furthermore , older adults appeared to be less likely than younger adults to perceive substance use as problematic or to use treatment services.
Furthermore , older adults demonstrated asymmetrical motor coordination between left and right task directions , while younger adults remained consistent regardless of task direction.
Furthermore , older adults do not show emotion recognition deficits when evaluating global emotions from dynamic images of faces.
Furthermore , older adults generated a larger N170 to letter than nonletter stimuli over the left , but not right hemisphere.
Furthermore , older adults in the workforce are working until later ages.
Furthermore , older adults showed learning impairments compared to younger adults.
Furthermore , older adults who displayed higher activity in prefrontal regions at pretest demonstrated larger training-induced performance gains.
Furthermore , older adults with better source memory were less biased than those with poorer source memory.
Furthermore , older adults with larger size in these callosal areas performed better on assessments of working memory and processing speed.
Furthermore , older characters were most often depicted within intergenerational and nonfamily contexts.
Furthermore , one group of aged naïve subjects was challenged with two herbicides ( Paraquat and Maneb ) known to cause oxidative damage.
Furthermore , ongoing research has sought reliable biomarkers of ageing that will accelerate the development of such therapeutics.
Furthermore , only in YA , increased encoding activity in ventrolateral PFC , and increased retrieval activity in occipital cortex , predicted increased retrieval accuracy.
Furthermore , only stem bark extract ( @number@ µg / mL ) was able to inhibit the depletion of glutathione ( @percent@ ) .
Furthermore , our data confirm the well-known positive association between age and glaucoma.
Furthermore , our data show disparities in brain neurotrophic factor levels may be exacerbated in HIV patients over @number@ years of age.
Furthermore , our data showed that expression of TET1 , but not TET2 and TET3 , was downregulated in HCC.
Furthermore , our findings indicate that neuroimaging-based measurements of cerebral variability are sensitive to genetic mediation.
Furthermore , our nuclear magnetic resonance spectroscopic studies identified the binding sites of Aβ with the amyloidogenic proteins.
Furthermore , our probe indicated that gefitinib was more efficient against HCC827 cells than against the other two NSCLC cell lines.
Furthermore , our results suggest a possibility of mediation of DNA methylation in the association between the genetic variants and SGA.
Furthermore , our studies found that MVs have the capacity to generate oxidative stress and consume nitric oxide.
Furthermore , overexpression of Parkin ameliorates the functional decline in aged hearts , and is accompanied by decreased senescence-associated β-galactosidase activity and proinflammatory phenotypes.
Furthermore , overexpression of α-syn A53T mutation significantly increased the CN-dependent nuclear import of NFATc3 in the mDA neurons of transgenic mice.
Furthermore , oxidative stress increased levels of ARP reactive RNA in cultured cells.
Furthermore , p16 expression was negatively correlated with liver regeneration in older patients ( R = @number@ P < @number@ ) .
Furthermore , p75NTR re-expression occurs in larger alpha motor neurons that express cleaved caspsase-3 and are destined to die.
Furthermore , pallidum , posterior putamen and VTA / SN connectivity to other TPN regions , such as somatomotor cortex , decreased with age.
Furthermore , partial knockdown of Pten rescues the toxicity observed in the NSC34 ( G4C2 ) 102 cellular gain-of-toxic function model of C9ORF72-ALS.
Furthermore , participants remembered more items than associations , regardless of encoding instruction.
Furthermore , participants were asked if they have ever received a previous diagnosis of depression.
Furthermore , participation in drumming did not result in acute hypotension in normotensive individuals.
Furthermore , patients in the PD-MCI group had significantly more nontremor features.
Furthermore , patients with dementia feel that the medication that will allow them to continue their lifestyle at home for long periods is limited.
Furthermore , patients with MCI showed significant discrepancies in the estimation of sleep onset latency when compared with HE subjects.
Furthermore , patients with stable MCI could be separated from patients with progressing MCI.
Furthermore , pch-2 overexpression in C. elegans extends worm lifespan , and enhances worm survival in response to various stressors.
Furthermore , peak flow as a function of respiratory muscle force was assessed.
Furthermore , people living in colder houses had worse physical performance.
Furthermore , people with a low education will multiply the relative risk of MetS compared with people with high education by almost @number@
Furthermore , @percent@ of the seafarers ( significantly more often Caucasians ) used sunscreens during sunlight exposure at sea.
Furthermore , @percent@ ( standard error @percent@ ) of liability of HPV-associated cervical pre-cancer and cancer is determined by common genetic variants.
Furthermore , performance at the @number@ follow-up sessions was better ( i.e. , reduced Stroop ratio interference score ) than baseline level.
Furthermore , persistent platelet activation despite antiplatelet therapy has been reported in this setting.
Furthermore , PFKFB3 expression also demonstrated an increase in these mice , although at a later age ( @number@ months ) than GFAP and Aβ.
Furthermore , PicroSirius Red and hematoxylin stainings were performed to visualize the collagen network and the cells.
Furthermore , Pld2 ablation rescues memory deficits and confers synaptic protection in SwAPP mice despite a significant Aβ load.
Furthermore , PLE promoted type I procollagen production irrespective of UV irradiation.
Furthermore , PlGF significantly accelerated hair follicle growth and markedly prolonged anagen hair growth in an in vivo model of depilation-induced hair regeneration.
Furthermore , PLSR identified @number@ aroma compounds which were mainly responsible for the olfactory notes of the AMW.
Furthermore , Polβ transcriptional expression was significantly lower in transgenic @number@ months old mice than in wt.
Furthermore , potential disease phenotypes associated with telomerase dysregulation in a specific stem cell population is also discussed in this review.
Furthermore , potential effects of age or gender are robust against the language background as no differences were observed between Polish and German subjects.
Furthermore , PPARγ overexpression in hADSC at passage @number@ improved the differentiation potential to insulin-producing cells.
Furthermore , practitioners must be fluent with the operation and expected complications of these new technologies.
Furthermore , pretreatment with proteasome inhibitor MG132 completely blunted oxidant-induced p21 degradation , indicating a proteasome-dependent action.
Furthermore , PRGF-Endoret stimulated global improvements in anxiety , learning , and memory behaviors.
Furthermore , products with \ "natural \ " matches between carriers and ingredients have the highest level of acceptance among consumers.
Furthermore , progenitor-like cells with long telomeres may be recruited to the most damaged areas of the cartilage.
Furthermore , progeroid fibroblasts display profound abnormalities in the nuclear lamina , including blebs and abnormal distribution of emerin , an interaction partner of BAF.
Furthermore , protein expression of this three-gene panel in biopsy samples distinguished Gleason @number@ patients who failed surveillance over a 10-year period.
Furthermore , proteomic analysis also demonstrates remarkable increases of complement factor B in GS and TGF-ß1 in both GS and i-GS.
Furthermore , PSMB5 overexpression retained the pluripotency of late-stage hBMSCs by facilitating their neural differentiation both in vitro and in vivo.
Furthermore , PYP1-5 upregulated transcription factor specificity protein @number@ ( Sp1 ) expression , which is reportedly involved in type @number@ collagen expression.
Furthermore , Q3GA increased the protein secretion of BDNF and its blockade using anti-BDNF antibody reversed Q3GA-induced proliferation.
Furthermore , qRT-PCR analysis of the AD postmortem brains with different Braak stages also showed upregulation of miR-455-3p ( P = @number@ ) .
Furthermore , rapid-acting ( RA ) insulins may have superior therapeutic effects compared with regular insulin types.
Furthermore , RBC membrane cis-vaccenic acid was inversely related to CHD.
Furthermore , recent studies point out changes in immune response related to use or cessation of hormone replacement at menopause.
Furthermore , recognition memory tests using emotional stimuli may be better able than neutral stimuli to differentiate people with aMCI from cognitively normal older adults.
Furthermore , recovery was not seen in all cognitive domains.
Furthermore , reduced activation was observed in the premotor cortex of the MCI patients.
Furthermore , reduced myofibroblast differentiation in LP fibroblasts was restored by a sialidase inhibitor.
Furthermore , regressions revealed that functional health decreased with increasing age in the total sample and in both sexes.
Furthermore , related and cross-referencing publications were reviewed.
Furthermore , researchers have identified several significant and suggestive genomic quantitative trait loci associated with physical activity.
Furthermore , research has demonstrated that testing individuals for apolipoprotein E can be valuable and safe in certain contexts.
Furthermore , results from the THA cohort echoed physiological justification and indicated significant improvements in muscle quality in both legs following surgery.
Furthermore , resveratrol in combination with genistein and quercetin synergistically decreased adipogenesis in murine and human adipocytes.
Furthermore , Retinol @number@.2% / LR2412 @percent@ cream is better tolerated and better perceived by women used to rejuvenation procedures.
Furthermore , RGFP963 increased hippocampal spine density , while HDAC3 inhibition was ineffective.
Furthermore , ROS generation induced by the blue-light irradiation was detected in mitochondria of HGFs using fluorimetry.
Furthermore , RPH3A expression is selectively downregulated in cultured neurons treated with Aβ25-35 peptides.
Furthermore , RTT was associated with difficulties in @number@ fundamental factors influencing sustained attention : engagement , distractibility , and reengagement.
Furthermore , salt- and detergent-soluble AChE activity was significantly decreased only in adult mice.
Furthermore , SBP reductions @number@ h post-CAS may predict the SBP reductions @number@ year post-CAS.
Furthermore , scopoletin enhances the level of transcription factors such as Nrf-2and p-FoxO1 related to anti-aging.
Furthermore , selective inhibition of MiDAS may comprise a potential therapeutic strategy to sensitize cancer cells undergoing replicative stress.
Furthermore , senescence decreases the ability of cells to transmit circadian signals to their clocks.
Furthermore , senescence-enhanced ultrastructural and functional alterations were revealed in the rodent studies.
Furthermore , separate analyses of herbal medicines , dietary supplements , or non-prescribed drugs did not correlate with adherence to prescriptions.
Furthermore , serial MRI may be required to monitor adverse side effects associated with such drugs.
Furthermore , several skin care companies have released new small RNA products in cosmetic market.
Furthermore S-FPC predicted death and hospitalization at shorter times than FPC ( P < @number@ ) .
Furthermore , significant activation in the left motor , somatosensory cortices and somatosensory association cortices was demonstrated.
Furthermore , significant activation of pro-mitotic pathways is consistent with dedifferentiation and cell proliferation events , which occur early in the pathogenesis of AMD.
Furthermore , significant age by CVRi interactions revealed that elevated CVRi in the thalamus was inversely related to verbal fluency performance in the very-old group.
Furthermore , significant age-related LPC repetition differences were revealed only with one intervening word lag for nonliving words.
Furthermore , significant increase in iron uptake as a function of age was found past the age of @number@
Furthermore , significant increases in skin water content were detected in E-AP-SM2001- treated mouse skin , as compared with vehicle-treated control skin.
Furthermore , significant interactions were observed between BMI and age , pointing to accelerated ageing of white matter structure in obese.
Furthermore , since D-β-Asp is a non-native amino acid , D-β-Asp-containing proteins may be recognized as allogeneic antigens.
Furthermore , since oral health and general health are inextricably linked , the integration of services may improve outcomes and lower costs.
Furthermore , SIRT1 overexpression by using adenoviral vector protected neuronal cells against PrP ( 106-126 ) .
Furthermore , SIRT6 knockout mice exhibit an accelerated aging phenotype and die prematurely.
Furthermore , some drugs like I-f channel antagonists and stress tests testing cardiac reserves could support such a study.
Furthermore , some studies have even suggested that FGF23 may have a protective role against vascular calcifications and CV disease.
Furthermore , some studies indicated an increase in gastric acid secretion in the old people compared with young people.
Furthermore , spacing thresholds did not change with age and approximated Bouma's law ( half eccentricity ) .
Furthermore , specifically selecting participants based on age , genetic loading or subclinical psychotic symptoms did not alter these findings.
Furthermore , specific treatment and format preferences varied by age group.
Furthermore , strength has a higher association with STW than turning duration.
Furthermore , strengths of crowding and surround suppression did not correlate with each other nor could they be predicted by efficiency of visual search.
Furthermore , stress had direct and indirect effects on each construct of mental health ( e.g. , fatigue , loneliness , and depression ) .
Furthermore , stride length is a good indicator to differentiate fallers from non-fallers in older men from the general population.
Furthermore , structure-based interaction analyses revealed an unprecedented mechanism involving CAMP's WK motif.
Furthermore , students were given the opportunity to explore the effect of aging on the elasticity of blood vessels.
Furthermore , studies have validated the ability of extracellular heat stress cognate @number@ to regulate cancer cell proliferation and sperm storage.
Furthermore , studies of mouse models and clinical samples demonstrated the importance of Hippo pathway dysregulation in human cancer development.
Furthermore , studies reporting associations have often utilized differing definitions of both COPD and periodontitis.
Furthermore , study @number@ implicated behavioral factors.
Furthermore , subcutaneous transplantation of these cells into immunodeficient mice resulted in teratoma formation in @number@ to @number@ weeks.
Furthermore , subjects with NAFLD had higher prevalence of diabetes , pathological waist-circumference , insulin-resistance and positive ATP-III criteria.
Furthermore , such emotional processes are thought to be aberrant in a range of clinical disorders , including psychosis and depression.
Furthermore , such trajectories were associated with the elders ' living condition.
Furthermore , sunitinib improves cognitive function , as assessed by several behavioral paradigms , in both AD animal models.
Furthermore , target-evoked sensory components were enhanced for attended relative to unattended targets in both younger and older groups.
Furthermore , task difficulty affected the pointing durations of middle-aged adults moreso than those of young adults.
Furthermore , telomere elongation during somatic cell reprogramming is of great importance in the acquisition of authentic pluripotency.
Furthermore , telomere length and integrity are regulated by a number of epigenetic modifications , thus pointing to higher order control of telomere function.
Furthermore , telomere loss and genomic instability were observed at a higher frequency in embryonic fibroblasts from Neil2-null mice than from the WT.
Furthermore , telomeres were shorter in cancer than in PanIN-1 and @number@
Furthermore , tendon stiffness increased in the GH group.
Furthermore , TG mice showed an attenuated fall in urine aldosterone with HSD.
Furthermore , the 13-valent pneumococcal conjugate vaccine is also available for administration in adults and is recommended by the STIKO for particular indications.
Furthermore , the 20GPPD-enhanced ERK and Akt signaling decreased following treatment with PP2.
Furthermore , the ability of simple measures of variability to predict mortality has not been compared with more complex measures.
Furthermore , the ability of the VACS Index to also reflect transitions in frailty status over time is unknown.
Furthermore , the advances in laboratory test methods have made the measurement of various sensitive markers for inflammation possible.
Furthermore , the age-dependent increases in visceral adipose tissue might lead to loss of skeletal muscle mass.
Furthermore , the age range covered was assessed.
Furthermore , the age-specific effects of syllable frequency provide insight into the progression of age-linked changes to phonological processes.
Furthermore , the angiotensin II component of the VC response appears to occur primarily through a ROCK-mediated mechanism.
Furthermore , the anti-aging effects of allicin were abolished by the Sirt1 inhibitor nicotinamide ( NAM ) .
Furthermore , the anti-oxidative stress index , SOD / MDA was dramatically elevated on LY333531 application.
Furthermore , the approaches performed here do not further support the hypothesis that LTL variation contributes to the genetic propensity for longevity.
Furthermore , the assay was extended to include prediction of beer tendency to sensory aging from freshly bottled beer.
Furthermore , the association between ADHD severity and depression was stronger in those who experienced serious conflicts and those who experienced more adverse life events.
Furthermore , the association between sgp130 and MS disappeared after adjustment for HOMA.
Furthermore , the association of high amyloid burden and loneliness was stronger in APOEε4 carriers than in noncarriers.
Furthermore , the association of TXNIP ( thioredoxin-interacting protein ) with NLRP3 induced by ROS promoted NLRP3 inflammasome activation in senescent endothelial cells.
Furthermore , the CCCTC-binding factor-dependent mechanism of homocysteine-reduced hTERT expression via DNA demethylation was confirmed in aortic endothelia of mice with hyperhomocysteine levels.
Furthermore , the change in priming across delays they displayed was not related to level of alerting or orienting.
Furthermore , the chapter proposes a research agenda for scholars interested in exploring the relationship between financial well-being and ageing.
Furthermore , the chronic CpG-island binding of p53 conferred distinct expression patterns between senescent and pro-apoptotic conditions.
Furthermore , the compound possesses anti-inflammatory activity and positively regulates glucose level and metabolism of adipose tissue.
Furthermore , the CONER nanoprobe was used to detect hydroxyl radicals in vitro using viable breast cancer cells exposed to oxidative stress.
Furthermore , the converse effects of ageing on the rsMEG variability were not mediated by vascular factors.
Furthermore , the Cox proportional hazards model was used to analyze which factors influenced the post-MI outcome and which influenced the appearance of VT.
Furthermore , the CR composite had a higher correlation ( r = @number@ ) and accounted for more variance than any of the independent proxies.
Furthermore , the cuticle becomes gradually less resistant to daily grooming stress.
Furthermore , the decline of arterial compliance and increase in arterial stiffness develops with age.
Furthermore , the decrease in ASMI with age is more striking than that of BMI.
Furthermore , the definition of CKD is a nosographic simplification that includes diseases with different causes and pathogenetic mechanisms.
Furthermore , the degree of individual-level protection conferred by elevated responses to these antigens has not yet been explored.
Furthermore , the development and repair of neural tissue depend on the proper intake of essential structural nutrients , minerals , and vitamins.
Furthermore , the difference between both attentional conditions for happy faces was larger in adolescents than adults.
Furthermore , the difference between times to complete the TMT-B and TMT-A significantly decreased from precycling to postcycling.
Furthermore , the difference in the P3 amplitude evoked by positive and negative feedback was significantly correlated with age.
Furthermore , the direct interaction between @number@'-THIF and endogenous PKCα was confirmed using the pull-down assay.
Furthermore , the discriminative capacity of the instrument has been rarely investigated.
Furthermore , the Drosophila Hippo pathway target bantam functionally mimics miR-130a by repressing the VGLL4 homolog SdBP / Tgi.
Furthermore , the ECQ data showed a significant positive correlation between individual physical activity and everyday competence.
Furthermore , the educational gap in depression diverges with age among individuals originating from a well-off family background.
Furthermore , the effect of LiCl is different on LPS and PAM3CSK4 responses.
Furthermore , the effect of reasons on attitudes toward own aging was mediated by negative views on aging.
Furthermore , the effect of resveratrol on Wallerian degeneration was lost when SIRT1 was pharmacologically inhibited.
Furthermore , the effects of commonly consumed orange juice flavanones on cognitive function remain unexplored.
Furthermore , the elderly people are sensitive to adverse events of AEDs , as for example , to cognitive disturbances , osteoporosis.
Furthermore , the EMT polysaccharides support the loading and release of the chondroinduction factor transforming growth factor β3 ( TGF-β3 ) .
Furthermore , the evaluation of iris freckles could also be helpful in understanding the role of sunlight in several ophthalmologic diseases.
Furthermore , the expression of both human-specific collagen type I and tenascin-C was significantly higher in the cell group than in the other @number@ groups.
Furthermore , the expression of Sox @number@ and type II collagen were higher in p53 normal control than p53 knockdown NP cells.
Furthermore , the expression of the protein isoform smLRP1 ( @number@ kDa ) was confirmed in human tumour cell lines.
Furthermore , the extent of changes in these variables during CO₂ challenge was correlated with the EEG coherence , as a reflection of neurovascular coupling.
Furthermore , the factors that exerted a positive impact on the success of therapy were registered.
Furthermore , the fall group significantly overestimated their OLS , TUG , and MSL.
Furthermore , the figures can be exported as commonly used image file formats or demonstration video for further use.
Furthermore , the findings emphasize a strong link between the individual cortisol response to stress and memory functioning among postmenopausal women.
Furthermore , the fluorescence lifetime was reduced in the in vitro models of reduced collagen crosslinking.
Furthermore , the fracture risk in patients with T2D is increased.
Furthermore , the free radical theory fails to explain why exercise causes higher levels of oxyradical damage , but generally promotes healthy aging.
Furthermore , the functional capacity of all three groups improved after the intervention.
Furthermore , the functional interaction is evolutionarily conserved , as mouse Ankmy2 interacts with guanylyl cyclase GC1 from ciliary photoreceptors.
Furthermore , the generally advanced age and frequent comorbid conditions present in OA patients limit safety of many available drugs.
Furthermore , the genetic amenability of Drosophila makes it an advantageous model species.
Furthermore , the government should acknowledge the inadequate health management capacity and invest to improve human resource management capacity at all levels.
Furthermore , the group-by-task interaction was significant in @number@ channels with young participants showing greater WWT-related increase in HbO2 levels compared with the old participants.
Furthermore , the highest levels of renal hydrogen peroxide , protein carbonylation and nitration were observed in aged WT mice.
Furthermore , the impact of oxidative stress on ARPE-19 cells was assessed by HO-1 and PARP-1 Western blotting and by the protection of antioxidant EGCG.
Furthermore , the impact of some relaxation interventions remained in effect for between @number@ and @number@ weeks after the interventions.
Furthermore , the increase in blood viscosity was similar in males and females and in subjects with CHD risk profile worsening or not.
Furthermore , the increase in these variables did not differ when a cold pressor test and lower body negative pressure were superimposed upon heating.
Furthermore , the inflammation secondary to obesity and aging introduces an increased risk of developing OA following meniscal injury.
Furthermore , the influence of interaural time differences ( ITD ) and aging effects on IM are considered.
Furthermore , their therapeutic limitations may be augmented when combination therapy is pursued instead of using a single agent.
Furthermore , the KOP-Q is suitable to make comparisons between the Netherlands and the USA using latent variable models.
Furthermore , the KOP-Q measures a second unidimensional construct , certainty of hospital nurses about their knowledge.
Furthermore , the L435F mutation impairs hippocampal synaptic plasticity and memory and causes age-dependent neurodegeneration in the aging cerebral cortex.
Furthermore , the lack of change in the choline-containing compounds concentration can be useful for differentiating Pelizaeus-Merzbacher disease from other white matter disorders.
Furthermore , the lack of consistent use of evidence-based , age-specific screening instruments to identify those at risk is another significant obstacle to successful treatment.
Furthermore , the LF thicknesses at L5-S1 bilaterally were significantly greater than on the corresponding sides at L4-L5 ( P < @number@ ) .
Furthermore , the longitudinal changes in attentional shift and memory were positively correlated with the prefrontal volumetric changes.
Furthermore , the long-term trend throughout the maintenance treatment period was evaluated separately using linear regression models.
Furthermore , the magnitude of increased apparent brain aging related to cognitive deficits.
Furthermore , the main receptorial targets , mechanisms and interactions are described in order to highlight the possible therapeutical potentials.
Furthermore , the maintenance of aerobic and anaerobic exercise capacities allowed this Olympic athlete to compete at the highest level for almost two decades.
Furthermore , the majority of the CD45RA⁻ CD27⁻ and CD45RA + CD27⁻ CD4 + T cells in CMV-seropositive donors are specific for this virus.
Furthermore , the marginal adaptation of iCEM in enamel deteriorated by simulated aging ( p = @number@ ANOVA ) .
Furthermore , the MAT detected normative decreases in executive ability in later life.
Furthermore , the Matrigel migration assay showed that SSeo effectively reduced TNF-α-induced HASMC migration compared with that in the control group.
Furthermore , the mean mRNA levels of TNF-α and IL-1β in microglia after treatment with the conditioned medium from P.g.
Furthermore , the median time for return to pretreatment rhytides was @number@ weeks longer in the combination therapy side.
Furthermore , the method is of general interest for the study of membrane traffic and aging.
Furthermore , the MF and MPF slopes were significantly lower in elderly men than young men but similar in the two women groups.
Furthermore , the modulation of its expression in physiological or pathological conditions may be of interest in different context , such as aging and cancer.
Furthermore , the modulation of spinal reflex excitability was analyzed at different torque levels ( 10-50% MVC ) .
Furthermore , the nature of this relationship , and how their interaction determines the presence of functional impairments are unknown.
Furthermore , the negative / positive rGMV correlates of empathizing and positive / negative rGMV correlates of systemizing overlapped substantially.
Furthermore , the neural model demonstrates that head orientation bandwidth increases can arise from decreased cortical inhibition.
Furthermore , the NLRP1 / Casp1 / Casp6 pathway increased amyloid beta peptide @number@ ratio in serum-deprived neurons.
Furthermore , the norepinephrine transporter ( NET ) is an important target for frequently prescribed medication in ADHD.
Furthermore , the number is growing as the elderly population increases.
Furthermore , the @number@ studies that involved an economic analysis indicated that outpatient arthroplasty is financially advantageous.
Furthermore , the @number@ year period prevalence of diabetes in monozygotic twins is compared with that in dizygotic twins.
Furthermore , the obese diabetic patients had higher mortality than did the obese nondiabetic patients with the same number of cancers.
Furthermore , the occurrence of neuropathic symptoms , which add to the overall neurologic disability of patients , has been described in all disease entities.
Furthermore , the overall endopeptidase activity of cysteine cathepsins in epidermis lysates decreased with age.
Furthermore , the overexpression of MT-I in SOD1 ( G93A ) mice reduced the number of spheroid-shaped astrocytes cleaved by active caspase-3.
Furthermore , the overexpression of Pin1 promotes Rb hyperphosphorylation upon S-phase DNA damage.
Furthermore , the parameters used for prediction are measurable with an unobtrusive sensor device during normal activities of daily living.
Furthermore , the participants rated the creams with respect to the acceptance , the subjective skin feeling after application and performed paired-comparison tests.
Furthermore , the patient cells were more sensitive to double-strand DNA breaks.
Furthermore , the phase of the oscillatory response to TMS becomes less consistent with age.
Furthermore , the phosphorylated form of AKT was increased in glycitin-treated cells after @number@ h and remained higher for @number@ h.
Furthermore , the positive association between the gait and cognitive tasks suggest that dual-task performance was not influenced by task prioritization strategies in this sample.
Furthermore , the positivity of domain-specific age stereotypes of a person predicted individual life satisfaction for the respective life domain.
Furthermore , the potential of physical activity and social integration to moderate the relation between diabetes and cognitive impairment is assessed.
Furthermore , the potential role of ROS in the activation of proteolytic systems in skeletal muscles is also discussed.
Furthermore , the prediction of falls on the outcomes was analyzed using a multivariate linear regression model adjusted for multiple confounding factors.
Furthermore , the prospective association of unforgiveness with self-reported health was mediated by a latent positive psychological traits variable.
Furthermore , the quality of breakfast is thought to affect the cognitive functioning of well-nourished children.
Furthermore , the quantitative data collected on the course of sCJD will be useful for future trials.
Furthermore , therapies that are indicated for WHO group @number@ PAH may be harmful in patients with WHO group @number@ PH.
Furthermore , the ratio and choroidal vascular diameter were compared between children and adults.
Furthermore , there are disagreements on determinant factors and associated comorbidities of RLS.
Furthermore there are no differences in distribution of gene variants , or response to treatment in the two groups.
Furthermore , there has been an unprecedented increase in average lifespan over the past century without corresponding extensions of fertile and healthy age spans.
Furthermore , there is a genuine gap of knowledge regarding miRNA expression and function in pancreatic alpha cells.
Furthermore , there is a need for outcome studies allowing for identifying successful implementation concepts.
Furthermore , there is a need to incorporate a cost-benefit analysis in future studies.
Furthermore , there is an increasing interest in better understanding the pathophysiologic correlations between hearing loss and dementia.
Furthermore , there is limited research investigating how deficiencies can be ameliorated with exogenous support ( auditory cues ) .
Furthermore , there is no evidence for an accumulation of previously described variants promoting longevity in the @number@ octogenarians.
Furthermore , the relationship between psychosis and cognition has not been adequately explored to this point.
Furthermore , the relationship between sensory acuity and L-span performance varied as a function of age and presentation level.
Furthermore , the relative importance of various polysomnographic , demographic and clinical characteristics in predicting subjective sleep quality is not known.
Furthermore , the reliability and accuracy of MMSE-MoCA conversion tables has not been properly evaluated.
Furthermore , the reported nonlinear response of cervical ligaments has been modeled with a combination of the previously reported hyperelastic and damage model.
Furthermore , the response to endogenous GnRH showed no significant differences either.
Furthermore , the response to lipopolysaccharide was defective in these @number@ groups , which showed weak induction of pro-inflammatory cytokines and reduced NFκB transcriptional activation.
Furthermore , the results indicate a gender-specific vulnerability of T2DM on cognition , especially in MCI subtypes.
Furthermore , the results obtained after lentiviral expression of α-syn suggest that antibodies might be blocking the extracellular truncation of α-syn by calpain-1.
Furthermore , the results pointed to an increased oxidative damage in the vicinity of the glycated residues.
Furthermore , the results suggest that hippocampal shape provides additional predictive value over hippocampal volume and that combining shape and volume leads to better prediction.
Furthermore , there was a moderate exposure-response relationship between the number of medicines and prevalent as well as incident frailty.
Furthermore , there was a trend for depressive symptom severity to be associated with lower ELISPOT counts.
Furthermore , there was no association between changes in circulating Irisin with body mass index , body fat , fat-free mass and muscle strength.
Furthermore , there was no difference between males and females with regard to sjTREC levels.
Furthermore , there was no statistically significant increase for chromosomal aberration and DNA damage to the study groups.
Furthermore , there was reduced modulation of activity within rIFG ( p < 0.02 ) on stimulus change.
Furthermore , there was some evidence for gene-environment interactions , including physical activity attenuating the effects on triglycerides.
Furthermore , there were significant aberrations in islet morphology in the VHL-knockout mice , likely due to increased islet vasculature.
Furthermore , the RGCs from tau P301L mice increased in size with age , and the RGCs from control mice decreased in size with age.
Furthermore , the risk of cortical cataract increased @percent@ ( @percent@ CI @number@.1%-2.0% ) when cumulative UV-B exposure time increased every one year.
Furthermore , the role of epigenetic changes in aging , especially changes in promoter methylation , was reported.
Furthermore , these cells may require expansion in vitro before use as well as for future research.
Furthermore , these data indicate that serum 25 ( OH ) D concentrations may affect PTH elevation in postmenopausal women with low calcium intakes.
Furthermore , these data suggest that basal ganglia dysfunction associated with PD may affect the later stages of speech motor learning.
Furthermore , these disorders are usually refractory to BZP hypnotics.
Furthermore , these effects were significantly coupled in that greater upmodulation was associated with lesser downmodulation.
Furthermore , these findings highlight the importance of considering individual differences in social anxiety when examining the neural response to social stimuli in adolescents.
Furthermore , these findings suggest that the associations between creativity and resting state brain connectivity patterns are different between males and females.
Furthermore , these marginal benefits come at a very high price of €110'@number@ per treatment.
Furthermore , these multi-functional cells had intermediate telomere lengths compared with cells producing only one or two cytokines after activation.
Furthermore , these nanoparticles promote bone accretion in young mice in vivo.
Furthermore , these pathogenic mechanisms appear to be closely interlinked to the cascade of events leading to cellular death.
Furthermore , these patients usually exhibit a multiple sleep-wake rhythm , and an advanced sleep phase.
Furthermore , these processes are likely to vary spatially and temporally for animal populations.
Furthermore , these products are not transferred from the cytosol to the membrane and must , therefore , be formed on the membrane.
Furthermore , these results allude to potential gene-gene interactions between APOE and either androgen receptor polymorphisms or genes associated with testosterone production.
Furthermore , these senescent cells promoted the growth of human tumor cells.
Furthermore , these signaling modules are likely to cooperate with other pathways involved in stem cell maintenance and differentiation.
Furthermore , these symptoms were also affected at different serum testosterone thresholds.
Furthermore , these underlying derangements are independently associated with an increased incidence of critical illness , resulting in a progressive downward spiral.
Furthermore , the significance of lipid rafts in Aβ aggregation and neurotoxicity is briefly summarized.
Furthermore , the simultaneous addition of rIGFBP4 / 7 increased senescence and induced apoptosis in young MSC.
Furthermore , the small molecule GPER blocker ( GRB ) G36 reduces blood pressure and vascular ROS production by selectively down-regulating Nox1 expression.
Furthermore , the steady-state cytosolic calcium concentration in these mutant cells remained markedly higher than the wild-type after SERCA inhibition by thapsigargin.
Furthermore , the steroidogenesis-related enzymes such as 3β-hydroxysteroid dehydrogenase ( HSD ) , 17β-HSD , and 5α-reductase expressions were significantly restored by resistance training.
Furthermore , the strong dose-dependent activation of TRPA1 currents by [ @number@ ] -shogaol was abolished by A-967079 ( a selective TRPA1 inhibitor ) .
Furthermore , the study population differs significantly from those seen in clinical practice.
Furthermore , the study supports that twinning per se is not a risk factor of cancer.
Furthermore the system architecture and possible applications for ARTs will be presented.
Furthermore , the telomere length and its rate of shortening did not relate to clinical and lung function parameters changes over @number@ years of follow-up.
Furthermore , the telomeres in UVA-treated cells were shortened compared to those of cells in the red light groups.
Furthermore , the two exercise regimens significantly decreased TF-rich / PS-exposed NDMP formation and depressed neutrophil / NDMP-mediated dynamic TG at rest and following HE.
Furthermore , the use of unicellular organisms like yeast Saccharomyces cerevisiae to explain the aging processes of multicellular organisms runs the risk of oversimplification.
Furthermore , the VACS Index predicted concurrent NCI beyond nadir CD4 and estimated duration of infection.
Furthermore , the vascular effects of androgens remain poorly understood and have been controversial for a long time.
Furthermore , the vegetable peptone-induced increase in cell proliferation and type I collagen production decreased upon treatment with the ERK inhibitor PD98059.
Furthermore , the vibro-ultrasound system has a potential to become a powerful tool for investigating the elderly's muscle diseases.
Furthermore , the weight bearing profile is dependent on the armrest height.
Furthermore , they did not change RCT or plasma lipid levels in mice.
Furthermore , they do not have a negative effect on cognitive function in older adults with or without AD.
Furthermore , they had greater functional synchronicity of activity between the precuneus and the rest of the default mode network at rest.
Furthermore , they had very low employment rates , and those in employment had a lower income level than employed control subjects.
Furthermore , they implicate dysregulation in these pathways as pathological mechanisms in HD.
Furthermore , they should be extensively investigated through randomized clinical trials.
Furthermore they should promote further clinical research focusing on controversial issues in the treatment of early-stage breast carcinoma.
Furthermore , they suggested RHAMM loss-of-function and spindle misorientation as an initiating event underlying both hypofertility and TGCT initiation.
Furthermore , they suggest that n-3 PUFA deficiency disrupts adolescent behaviors through enhanced dorsal striatal dopamine availability.
Furthermore , TH-immunoreactive neurons decreased significantly with aging , which was associated with accumulation of NM and α-synuclein.
Furthermore , this amount of motor decline per year was associated with about a @percent@ increased risk of death.
Furthermore this association was modified by HT use.
Furthermore , this damage response is shown to be independent of progerin farnesylation , implying that unprocessed lamin A alone causes replication stress.
Furthermore , this finding suggests that efforts to preserve or increase brain GABA levels could be fruitful in remediating WM-related deficits associated with neuropsychiatric conditions.
Furthermore , this knowledge is essential for identifying pathways and molecular targets for therapeutic intervention.
Furthermore , this leads to a natural look without a significant downtime.
Furthermore , this mechanism may be a common aging process that occurs in long-lived proteins of other tissues leading to protein aggregation diseases.
Furthermore , this nascent examination of the I-SSST suggests a possible alternative for inducing stress in the laboratory. © @number@ Wiley Periodicals , Inc.
Furthermore , this patient group was compared to the patients < @number@ years.
Furthermore , this procedure provides different parameters that have been related to underlying cognitive processes in the literature.
Furthermore , this process was triggered via increase ubiquitination by the E3 ligase , Mule , rather than via de-ubiquitination by USP9X.
Furthermore , this study confirmed TUG1 could been in combination with miR-421 , and TUG1 and caspase-3 were both a directly target of miR-421.
Furthermore , this study integrates a semiconductor sensor with a microfluidic chip.
Furthermore , this study's focus on race addresses a notable gap in the growing literature on older prisoner health.
Furthermore , this study sheds light on other gaps in diabetes care quality among patients with diagnosed diabetes and corresponding poorly controlled diabetes.
Furthermore , this tool may be a useful instrument for assessing older ethnic Korean residents who reside in nursing homes that are located outside Korea.
Furthermore , though well accepted as a marker for vaccine response , assigning thresholds with HI has limitations.
Furthermore , through meta-analysis of cell cycle and chronological aging-associated transcriptome datasets , we constructed coexpression networks and identified coexpressed gene clusters.
Furthermore , Tif1g deletion induced the age-dependent appearance of a cell-autonomous myeloproliferative disorder in mice that recapitulated essential characteristics of human CMML.
Furthermore , TNF-α-induced cPLA2 promoter activity was abrogated by transfection with the point-mutated AP-1 cPLA2 construct.
Furthermore , to detect DNA damage and telomere dysfunction , γH2AX foci and telomere dysfunction-induced foci ( TIFs ) were examined using immunofluorescence microscopy.
Furthermore , to evaluate its role in ethnic Chinese population , a meta-analysis was performed on Pro755Leu in population of Chinese ancestry throughout Asia.
Furthermore , topical application of EG showed significant reductions in skin dryness , thickness , and fragmented collagen fibers in UVB-exposed hairless mice.
Furthermore , topical application of PTD-EGF and FGF1 contained ampoules which were considered to improve the wrinkle parameters of human skin.
Furthermore , topical application of triolein ( @percent@ ) significantly prevented UV-induced MMP-13 , COX-2 , and IL-1beta expression in hairless mice.
Furthermore , to project the number of individuals likely to have HF in the future.
Furthermore , torsinA targeted mutant SOD1 for degradation via the proteasome , representing mechanistic insight on the activity that torsinA has on aggregate-prone proteins.
Furthermore , transfection of miR-630 mimics into cell lines overexpressing circRNA 100269 blocked the function of circRNA 100269 ( p < 0.05 ) .
Furthermore , treatments that promote myelination contribute to the recovery of neuronal function and improve cognition.
Furthermore , treatment with 4-hexyl-1 , 3-phenylenediol resulted in a twofold greater clinical improvement in overall photodamage compared with the vehicle group.
Furthermore , treatment with GH or IGF-I reduced circulating humanin levels in both mice and human subjects.
Furthermore , treatment with MK-801 , an antagonist of NMDA receptors , significantly alleviated abnormal EEG recordings induced by miR-219 antagomir.
Furthermore , treatment with mTOR inhibitors reduced colony size and proliferation of a PTEN negative endometrial cancer cell line in 3D culture.
Furthermore , TRT led to a significant increase in IIEF-5 score and a significant decrease in IPSS score.
Furthermore , truncated PrP ( C ) species were detected in sCJD and control samples without discernible differences.
Furthermore , TRX80 was found to colocalize with tumor necrosis factor-α , a macrophage M1 marker , in human atherosclerotic plaque.
Furthermore , T-SCE-driven premature cellular senescence may be a factor contributing to accelerated aging in Werner and Bloom syndromes , but not XFE progeroid syndrome.
Furthermore , tumors may become more aggressive and drug-resistant with advanced age , leading to poor patient prognosis.
Furthermore , TV viewing may be particularly detrimental to cognitive performance later in life.
Furthermore , TβRII physically interacted with the constitutively active MEK1 , but not with wild-type MEK1 , indicating involvement of active MEK1 in stabilizing TβRII.
Furthermore , ubiquitination and proteasomal degradation are not completely congruent , since ubiquitination confers also functions different from targeting proteins for degradation.
Furthermore , understanding of these inflammatory mechanisms should lead to new therapeutic approaches for cholestatic liver diseases.
Furthermore , understanding why and how a fall occurred is a challenge.
Furthermore , upon alcohol exposure murine embryonic fibroblasts exhibited increased Plk4 hypermethylation and downregulation along with increased centrosome numbers and multinucleation.
Furthermore , upon discontinuing treatment , any gain that has been achieved is quickly lost.
Furthermore , upon knocking down Sirt1 , the effect of Rb1 on HUVEC senescence was blunted.
Furthermore , upper cervical levels showed a higher frequency of central disc herniation than lower cervical levels in the elderly.
Furthermore , using small-molecule high-throughput screening , we identify the MEF2C-PGC1α pathway as a therapeutic target to combat PD.
Furthermore , using the Wolbachia strain WMel reduces the mosquito lifespan by at most @percent@ and allows them to persist in competition with non-Wolbachia-carrying mosquitoes.
Furthermore , ( v ) antithrombotic activity ( @number@ mg / kg ) and ( vi ) bleeding time in murine models were evaluated.
Furthermore , VDAC1-ΔC was detected in tissues of @number@ % of @number@ patients with lung cancer.
Furthermore , viscolin pre-treatment significantly reduced neointimal hyperplasia of an endothelial-denuded femoral artery in vivo.
Furthermore , walking speed and TUG time correlated most strongly with many of the outcomes highlighting their importance as global indicators of physical capacity.
Furthermore , WBC iNOS activity in elderly patients was significantly decreased compared to the adult group.
Furthermore , we additionally demonstrated that rs2908007 is strongly associated with BMD at several sites in the young , elderly and complete OAS population.
Furthermore , we administered to explore its reliability and validity in the present population.
Furthermore , we also conducted a case-control study between the controls and essential hypertensive cases.
Furthermore , we also present lexical frequency data derived internet search hits.
Furthermore , we analyzed bimanual behavior and hand dominance in the task using different conditions of execution.
Furthermore , we analyzed the GWAS of eight phenotypes with three observations on each individual in the Korean Association Resource ( KARE ) .
Furthermore , we analyzed the senescence related β-galactosidase activity and CD146 and found that miR-495 induced the senescence of MSCs.
Furthermore , we appraise the differences between those pacemakers currently released to market.
Furthermore , we assessed whether hippocampal shape provides additional predictive value independent of hippocampal volume.
Furthermore , we calculated the index value of influenza in crude and age adjusted rates to evaluate the incidence of influenza by Mosaic segmentation.
Furthermore , we correlate the individual alpha-to-gamma difference in relative visual-area power ( ΔRV ) with cognitive scores for the older adults.
Furthermore , we demonstrated that age-related loss of SirT1 was associated with the induction of VSMC senescence.
Furthermore , we demonstrated that respiration scoring according to AASM @number@ results in higher AHIs , and challenge the use of age-independent respiratory cutoff values.
Furthermore , we demonstrated that the neuronal connectome , but not the tau strain , determines which brain regions develop tau pathology.
Furthermore , we demonstrate that age-related IFN-I milieu downregulates microglial myocyte-specific enhancer factor 2C ( Mef2C ) .
Furthermore , we demonstrate that miR-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth.
Furthermore , we demonstrate that PTX3 participates in the attenuation of macrophage-mediated phagocytosis of damaged neuron cells.
Furthermore , we describe the current state of induced pluripotent stem cell technology and applications for disease modelling and cell replacement therapy.
Furthermore , we detected the presence of functionally active half-palindromic estrogen responsive elements upstream the coding region of the seladin-1 gene.
Furthermore , we determined the sensitivity and specificity of Southern blotting of the C9orf72 hexanucleotide repeat in DNA derived from lymphoblastoid cell lines.
Furthermore , we determined whether this matrix has a potential inhibitory or enhancing effect on the PCR genotyping reactions.
Furthermore , we discuss emerging roles for mitochondrial sirtuins in suppressing and / or promoting tumorigenesis , depending on the cellular and molecular context.
Furthermore , we discuss potential functions of neuronal and glial MVBs in development , in dystrophic neuritic syndromes , injury , disease , and aging.
Furthermore , we discuss the potential impacts of leptin resistance on the decline of brown adipose tissue thermogenesis observed in elderly individuals.
Furthermore , we discuss the potential of a wide array of DAMPs as therapeutic targets in sepsis.
Furthermore , we discuss the role of skeletal muscle transverse tubules as potential modulators of tissue insulin responsiveness.
Furthermore we evaluated fluorescent advanced glycation end products ( Ex = 370nm , Em = 440nm ) and the activity of HDL-paraoxonase.
Furthermore , we evaluated the effects of several other known secretase modulators on η-processing of APP.
Furthermore , we evidenced that Edaglitazone increases intraplatelet cAMP levels and prevents PPARγ secretion , explaining its greater antiplatelet activity.
Furthermore , we examined the association between this neuronal activity metric and glucose metabolism from 18F FDG-PET.
Furthermore , we examined the role of ACSL3 in the androgen metabolism of prostate cancer.
Furthermore we examined the steroid receptor expression among untreated women in each period of life.
Furthermore , we examined whether patients classified as AAPR-secure reported better adjustment to medical burden in terms of higher life satisfaction than did insecure patients.
Furthermore , we examined whether sensory-related cognitive decline depends on cognitive demands and on the sensory modality used for assessment.
Furthermore , we explored this association within the context of vascular factors.
Furthermore , we explore the emerging concepts that peroxisomes and mitochondria share an intricate redox-sensitive relationship and cooperate in cell fate decisions.
Furthermore , we extended our analysis of DNA methylation across the entire X-chromosome which revealed no methylation-specific differences between PD females and healthy controls.
Furthermore , we find high levels of confounding between age-related variability and cellular composition at the CpG level.
Furthermore , we find some evidence for a protective effect of schooling on cognitive decline in terms of verbal fluency.
Furthermore , we found a negative interaction effect between physical disability and cognitive impairment for elderly home care users.
Furthermore , we found a robust positive correlation between source attribution ability and recognition accuracy.
Furthermore , we found a task-dependent change in connectivity during the encoding task between cerebellum-occipital areas and the TMS-targeted left inferior frontal region.
Furthermore , we found no evidence for age variations in the SES-BMI linkage as predicted by prior investigators.
Furthermore , we found that a receptor tyrosin kinase ( RTK ) was involved in ECCM-induced β-catenin-dependent transcription.
Furthermore , we found that Cav-1 coimmunoprecipitated with DISC1 in brain tissue.
Furthermore , we found that CLDN8 regulates intracellular signal transduction and stabilizes the cytoskeleton.
Furthermore , we found that common deletion mutation in mtDNA was more prevalent in distal sural nerves compared to dorsal root ganglia.
Furthermore , we found that E-cadherin expression decreased with the overexpression of GSN in H9c2 , but β-catenin expression increased.
Furthermore , we found that eupatilin subsequently suppressed IκBα phosphorylation , blocked NF-κB p65 nuclear translocation and down-regulated MAPK / AP-1 signaling via PPARα activation.
Furthermore , we found that image features for efficient discrimination reside in cellular components.
Furthermore , we found that knockout of RecQL4 destabilized PINK1.
Furthermore , we found that Neuropep-1-injected 3xTg-AD mice exhibit dramatically reduced Aβ plaque deposition and Aβ levels without affecting tau pathology.
Furthermore , we found that prednisolone at 1-4 mg / day was associated with serious infections in biologics-treated patients , but not non-biologic DMARD-treated patients.
Furthermore , we found that thinner RNFL and GCL were associated with worse white-matter microstructure.
Furthermore , we found that this occurs in an UCP2-dependent manner.
Furthermore , we found that TPP1 could homodimerize through its OB-fold , a process that was dependent on the Akt kinase.
Furthermore , we have determined the passage number at which primary myoblasts from adult and aged people undergo senescence in an in vitro culture.
Furthermore , we have developed a method for selectively labeling and visualizing active cathepsin X in vitro and in vivo.
Furthermore , we have performed a serious of network analyses , such as the PPI network , cross-tissue networks and pathway interaction networks.
Furthermore , we have shown that even slight DNA degradation ( modeled by sonication of genomic DNA ) leads to false rTL shortening.
Furthermore , we hypothesized that there would be larger volume differences in the parahippocampal gyrus than in the hippocampus.
Furthermore , we identified GDF-5 as the direct target of miR-21 during the regulation of chondrogenesis.
Furthermore , we identified loss-of-function OTUD3 mutations in human cancers , which either abolish OTUD3 catalytic activity or attenuate the interaction with PTEN.
Furthermore , we identified no significant association between ADHD symptom severity and regional NET availability.
Furthermore , we identified @number@ regions of the genome that display significantly high heritability estimates.
Furthermore , we identified S-allyl-L-cysteine ( SAC ) as one of the most active chemicals responsible for the AGE-mediated effect ( s ) .
Furthermore , we identify Osterix ( Osx , a transcription factor that is indispensible for bone formation ) as a target gene of XBP1.
Furthermore , we identify significant differences in age-acceleration dependent on the lipid content of the diet.
Furthermore , we intended to replicate the previous association of the SOD2 SNP rs4880 with longevity observed in a Danish cohort.
Furthermore , we investigated if total GS levels in CSF could differentiate AD from frontotemperal dementia and dementia with Lewy bodies patients.
Furthermore , we investigated the inhibitory mechanism of EGCG on heat-induced MMP-1 expression.
Furthermore , we investigated the mitochondrial network during differentiation processes of keratinocytes within the epidermis of volunteers.
Furthermore , we investigated threats to effectiveness , such as participant adherence , group reached , and program fidelity.
Furthermore , we investigated whether the nature of the attentional demands or task difficulty predicted the age at which stable levels of performance were reached.
Furthermore , we noted an increase in the concentrations of insulin-like growth factor-1 and dehydroepiandrosterone in the long-term training group.
Furthermore , we observe an increase in expenditures for the 0-year-olds.
Furthermore , we observed a large number of binucleated and apoptotic cells-signs of failed cytokinesis that we also observed in experimentally KIF14-depleted cells.
Furthermore , we observed a total absence of saccades with express latency.
Furthermore , we observed neutrophilic infiltration was slightly increased in anti-CD47 treated tumors compared to IgG control.
Furthermore , we observed that NHEJ efficiency declined with age.
Furthermore , we observed that proteasomal inhibition caused accumulation of SQSTM1 / p62 bound irreversibly to perinuclear protein aggregates.
Furthermore , we performed double staining of each GVD marker with pTDP43 to verify the co-localization.
Furthermore , we pooled individual data of six of these randomized double-blind placebo-controlled trials.
Furthermore , we propose a conceptual link between primary FTLD-tauopathy and ARTAG-related astrocytic tau pathologies.
Furthermore , we provide a hypothetical model for the heterogeneity described among individuals during ageing.
Furthermore , we review specific molecular mechanisms through which neuronal hyperactivity affects Aβ production and degradation.
Furthermore , we saw strong volumetric degeneration of functionally defined cerebellar regions associated with cerebral somatomotor function in both groups.
Furthermore , we separated gray and white matter brain sections to identify the cellular origin of the altered miRNA expression.
Furthermore , we show STAT1 / 3 activation is necessary for cytokine and ROS production during TNFα-induced senescence.
Furthermore , we show that AIEC remained within single-membrane LC3-II-positive vesicles and that they were unable to induce the phosphorylation of ULK1.
Furthermore , we show that CSB accumulates at sites of DNA double-strand breaks ( DSBs ) in a transcription-dependent manner.
Furthermore , we show that DBC1 itself is a substrate for SIRT1.
Furthermore , we show that increasing age in mice and humans is associated with increased methylation of the SRD5A2 promoter and concomitantly decreased protein expression.
Furthermore , we show that this occurs also in areas implicated in the molecular disturbances and in vivo neuronal networks related to heroin abuse.
Furthermore , we significantly reduce the size of the PARK10 region.
Furthermore , western blot analyses demonstrated that spermine modulates the expression of proteins related to autophagy and apoptosis.
Furthermore , we studied the dose-response effect of increase in physical activity on metabolic outcome within the intervention group.
Furthermore , we study education effects on cognitive decline.
Furthermore , we used MRI data from @number@ different scanner sites.
Furthermore , we used surgeons ' unique identifiers to examine how their practice preferences have changed over time.
Furthermore , we used the same task as a window to observe the involvement of motor imagery through the same age groups.
Furthermore , we utilized the network to predict candidate genes for mitochondrial diseases using prioritization algorithms.
Furthermore , we will compare ginsenoside and gintonin based on the modern view of molecular pharmacology in terms of ion channels and GPCRs.
Furthermore , we will discuss autophagy as a potential therapeutic target to mitigate the adverse effects of aging and age-related diseases on brain function.
Furthermore , we will discuss the potential impact of novel tracers that are currently under development or testing in preclinical models.
Furthermore , we wished to determine if A-LOC is an age-dependent phenomenon in VVS and whether haemodynamic parameters on tilting can predict for A-LOC.
Furthermore , WIF1 expression inhibited cell proliferation in vitro , reduced anchorage-independent growth in soft agar , and completely abolished tumorigenicity in vivo.
Furthermore , Wip1 could be an important factor that contributes to tumor heterogeneity , suggesting that its inhibition may decrease the rate of cancer evolution.
Furthermore , wives continuing as caregivers have more follow-up depressive symptoms than wives who do not provide care.
Furthermore , working memory weaknesses may underlie the academic problems often seen in children with ADHD.
Furthermore , XN treatment triggered p38 mitogen activated protein kinase and its specific inhibitor inhibited the paraptosis of HL-60 leukemia cells by XN.
Furthermore , yCAR-T contained higher proportions of CD4 and CD8 effector memory ( EM ) cells , which are known to have enhanced cytolytic capabilities.
Furthermore , younger adults outperformed the elderly regardless of type of encoding.
Furthermore , younger and older adults maintain the ability to use new knowledge to guide their associative judgments.
Furthermore , young women's tissues differ slightly from older women's tissues.
Further , mortality was noted in half of the @number@ skin disease categories.
Further motivation could be in finding answers to why hair follicle and epidermal pigmentary units remain broadly distinct ?
Further , much progress has been done in the improvement of therapeutic strategies , including lifestyle interventions , pharmacological , and mitochondria-targeted therapeutic approaches.
Further , negative age stereotypes and negative self-perceptions of aging were weakened.
Further new user design studies are required for cardiovascular outcomes and to compare the predictive value of different PIM criteria for mortality.
Further , new work suggests that Mn exposures correlating to optimal cognitive scores in children are associated with cognitive decline in adults.
Further , no association was found between ageism and sexism and sexual prejudice in the multivariate analyses.
Further , no change in proliferation rates of cultured ASCs was found , and expanded cells from all patients were capable of tri-lineage differentiation.
Further , non-carrier relatives of such heterozygous individuals had somewhat shorter leukocyte telomere lengths than expected ; this difference was most profound for granulocytes.
Further , no significant differences in postoperative IPSS , quality of life , or bladder neck contracture ( P = 0.23 ) were observed.
Further , no studies have evaluated these associations in US populations or investigated whether associations differ in diabetic as compared to non-diabetic populations.
Further , @number@ groups were created based on CVD risk and cognitive function.
Further , @number@ nM BPA and E2 possessed equimolar membrane-initiated signaling with robust induction of p-Akt and p-Erk at @number@ minutes.
Further , @number@ participants accepted to undergo blood withdrawal.
Further observational and interventional studies should explore short-term dynamic and bidirectional associations and the effects of frailty reversal on depression risk.
Further , older adults who live alone are @percent@ more likely to suffer an unintentional injury than the rest of the population.
Further , older age was related to greater daily alpha-amylase output and attenuated wake-evening slopes.
Further , only @percent@ always or often discussed potential side effects / interactions of these supplements with their patients.
Further , our data indicate that macrophage Eng deletion is insufficient and that endothelial Eng homozygous deletion is required for HHT1 brain AVM development.
Further , our findings suggest that AD pathology and WMHs appear to be linked with ineffective increases in frontal response in CN older adults.
Further PA domain specific studies using longitudinal design and clear measures of SES and PA assessment are required.
Further , pain has been related to the neuropsychiatric symptoms of agitation , aggression , mood syndrome and sleep problems.
Further , participants must monitor motor output to make adjustments in the absence of visual feedback.
Further , @percent@ of graduates reported success in gaining age-related employment shortly after graduation.
Further , physical activity promotion should be integrated into multidimensional health promotion to meet the diverse health needs of patients.
Further PK explorations of ATV in the extremely aged population are warranted.
Further population-based studies are needed to refine the population incidence and risk factors for paralyses in the aging population.
Further , pressure across coated microchannel networks took over @number@ times longer to double than the uncoated controls.
Further , prevalence estimates of Alzheimer's disease ranged from @percent@ to @percent@ , and vascular dementia from @percent@ to @percent@.
Further , previous studies show that the mitogen-activated protein kinase pathway can induce cardiac hypertrophy.
Further primary research involving theory as a central component of intervention development is required.
Further programs and studies must be developed to address the refractive errors needs of the adult Puerto Rican population.
Further progressed @number@ dimensional femoral neck strength analysis using CT scanning are now under development.
Further prospective investigations are mandatory in order to correctly address this question.
Further prospectively randomized studies are needed to definitively evaluate the safety and feasibility of MIS in early-stage type II endometrial cancer.
Further prospective research is required to determine best practices and multidisciplinary protocols to further reduce rehospitalization rates in this population.
Further prospective studies are necessary to strengthen the predictive power of the index.
Further prospective studies are needed to confirm the present association.
Further prospective studies are needed to confirm these findings.
Further prospective studies are warranted.
Further qPCR verification showed that the expression of miR-1915-3p , miR-1207 , miR-3665 , and miR-762 correlated with the expansion time at passage @number@
Further qualitative research describing self-care experiences of home-dwelling elders from different cultures , education levels , and social backgrounds is needed.
Further quantitative analyses revealed linear decreases in modularity and inverted-U shaped trajectories of local efficiency and rich club architecture.
Further , racial differences in telomere length are found in a range of different peripheral tissues.
Further randomized controlled trials are needed to support these results.
Further , rather than causing depression , hypercortisolemia could represent a homeostatic attempt to overcome glucocorticoid resistance.
Further RCTs are warranted to establish their long-term efficacy and safety.
Further , recognition of predisposing factors and the salience of differential ages of onset have led to more pragmatic diagnostic systems.
Further , RE is an effective intervention for improving all measures of body composition and functionality.
Further replication in other countries or other populations is highly expected.
Further research aimed at understanding the specific mechanisms by which TCM affects health outcomes is warranted.
Further research based on controlled clinical trials is necessary to reach consistent conclusions.
Further research can examine the effects of specific branches of yoga on a designated clinical population.
Further research comparing the muscle coordination and mechanics of falls and recoveries within subjects is necessary to establish the neuromuscular causation of falls.
Further research emphasis on rodent telencephalic neurocircuitry could be relevant to more valid and reliable preclinical research on these most devastating brain disorders.
Further research , especially trials , is necessary to estimate the public health impact of such interventions.
Further researches should be focused on the mechanism of these associations.
Further research including longitudinal studies and large scale , multi-site samples would add to the existing knowledge.
Further research , including on natural history and genetics , is crucial to expand the understanding of GA pathophysiology and identify effective therapeutic targets.
Further research including the objective measure of MM is needed to determine the accuracy of these specific cut-off points.
Further research in female twins and larger cohorts is warranted.
Further research in protective genetic factors is needed.
Further research in this area comparing different interventions and timing is needed.
Further research in this field is warranted.
Further research into the acceptability of screening tools focusing on the outcomes of nutrition screening and appropriate nutrition intervention are required.
Further research into the best treatment options for rare malignancies is needed to further improve survival.
Further research into the links between the processes of placentation and the morphology of the placenta at birth is now required.
Further research into these issues is required.
Further research investigating the basis of this connection as well as the pathomechanism of the two diseases will further our ability to treat dementia.
Further research is critical in evaluating the potential use of probiotics in respiratory infections and vaccination in the ageing population.
Further research is encouraged in populations of diverse religiosity.
Further research is expected to clarify the mechanism of visual function or the impact of restored vision on frailty.
Further research is , however , necessary using other approaches.
Further research is necessary in order to discern the most effective types of both intervention models.
Further research is necessary to assess the effect of early interventions in case of cognitive dysfunction.
Further research is necessary to investigate whether epimutations can be found on other nonimprinted gene promoters as well.
Further research is necessary to more fully understand the impact of multiple forms of social supports on the diet quality of older adults.
Further research is necessary to understand the basis of this association and whether these pathways might be amenable to hearing rehabilitation.
Further research is necessary to understand the relationship of MRI variables and ligament degeneration.
Further research is needed addressing gender differences , and clinical trials should routinely control for gender bias.
Further research is needed , given the salience of physical frailty and burden.
Further research is needed on effective methods to deliver multifaceted fall interventions to older adults who are already being served by community health promotion programs.
Further research is needed on staff knowledge about the assessment and treatment of urinary incontinence.
Further research is needed regarding the relationship between living alone and health outcomes in older men.
Further research is needed to better understand how multidisciplinary teams influence care of hospitalized older adults.
Further research is needed to better understand the causal mechanisms that drive these associations.
Further research is needed to clarify in greater detail positive and negative effects of muscle coactivation on postural control.
Further research is needed to clarify negative and positive effects of muscular coactivation during walking in fearful subjects.
Further research is needed to determine how health services can support , identity and promote health for older Indigenous Australians.
Further research is needed to determine mechanisms and early intervention strategies to slow functional decline.
Further research is needed to determine the direction of association between plasma TGF-β and the risk of CKD and CKD-associated morbidities in older adults.
Further research is needed to determine the mechanisms and clinical implications of these findings.
Further research is needed to determine whether muscle mechanography can predict outcomes such as falls , fractures , and mortality.
Further research is needed to develop an overall dietary assessment tool in relation to bone health for postmenopausal women.
Further research is needed to develop the COPE Index to more precisely measure positive value of the caregiving process.
Further research is needed to develop understanding of how identity and mental well-being are maintained , despite changes in everyday activities like cooking and eating.
Further research is needed to distinguish between alterations that are secondary to AD and those that contribute to the disease process.
Further research is needed to elucidate the underlying mechanism.
Further research is needed to elucidate the underlying mechanism of the association between uric acid and BMD.
Further research is needed to enhance the Omaha System to formally represent strengths-based as well as a problem-focused perspectives.
Further research is needed to establish exactly how UI has an impact on seniors ' feelings of loneliness.
Further research is needed to establish how the causes and consequences of CVD are related to nutrition risk.
Further research is needed to establish the optimum intervention period and to assess the possibility of nationwide implementation of the HCSMP-NHR.
Further research is needed to establish the utility of CGA in predicting toxicity and to evaluate the quality of survival in older adults undergoing HCT.
Further research is needed to establish valid and reliable predictors of mortality risk , to develop effective preventive strategies in those vulnerable populations.
Further research is needed to explain the differential effect of n-3 PUFA on AD according to ApoE genotype.
Further research is needed to explore the effects of advancing age and disability on choice step reaction in a speed or accuracy strategy.
Further research is needed to gain a better understanding of the mechanisms that contribute to deprivation-related horizontal inequities in DMP enrolment among women.
Further research is needed to gain insight into aging perceptions and their health and sociodemographic correlates in this population.
Further research is needed to identify additional sites of age-related methylation and allow accurate age prediction in dogs.
Further research is needed to identify factors that influence decline rates and to develop interventions that slow cognitive aging.
Further research is needed to identify other potential mechanisms of sarcopenia as well as effective interventions for the prevention and treatment of sarcopenia.
Further research is needed to identify the determinants of age group differences.
Further research is needed to include culturally acceptable activities for the frequency sub-scale.
Further research is needed to investigate causes responsible for differences between German and USA cancer survival rates.
Further research is needed to investigate ethnic differences in levels and determinants of loneliness.
Further research is needed to reach more definite conclusions.
Further research is needed to replicate these findings and to determine how prevention education can reduce these risks for older adults.
Further research is needed to shed light on the intriguing link between depression and associated factors in geriatric population.
Further research is needed to study the responsiveness and beneficial effects of these self-tests on self-management of mobility and fall risk.
Further research is needed to understand short-term and long-term cognitive effects of estrogen exposures closer to the age of menopause.
Further research is needed to understand the adverse physiologic effects of discrimination to create effective interventions.
Further research is needed to understand the natural history of incidental thrombosis in order to develop adequate management guidelines.
Further research is needed to understand the paradoxical pattern of discrepant subjective well-being versus objective health in age.
Further research is needed to understand the physiologic foundations of this association.
Further research is needed to validate the reduction in falls from this type of intervention.
Further research is needed to validate these findings in other T2D patient populations.
Further research is needed with different cohorts as well as with additional variants in the FNDC5 gene or in other genes involved in irisin signaling.
Further research is now required to evaluate the feasibility of implementing the intervention in a range of clinical practice settings.
Further research is recommended on symptom progression in PLWH.
Further research is recommended to explore the amenability to change of characteristics that hamper people from taking control over their lives.
Further research is required to address questions pertaining to the presence , nature , and impact of patient-centred audiological rehabilitation.
Further research is required to ascertain whether grip strength may help identify people at risk of adverse health outcomes within these settings.
Further research is required to assess the clinical outcomes of supplement use.
Further research is required to clarify how the indicators already identified may provide cognitive reserve and offer a protective effect against dementia.
Further research is required to determine the clinical utility and if it will improve the safety of medication use.
Further research is required to determine whether activated macrophages can serve as therapeutic targets in nvAMD.
Further research is required to elicit the potential mechanisms whereby whole- and refined-grain foods may influence body fat distribution.
Further research is required to establish if this is a causal relationship , or due to residual confounding by age , IOP , or CCT.
Further research is required to explore associations between different measures of anticholinergic exposure and clinically relevant outcomes in older people on a population level.
Further research is required to investigate if the subtle gait changes observed in this population become more apparent with aging and increased cannabis use.
Further research is required to produce an evidence base for the use of such aids in this group of people.
Further research is required to verify these results and to examine the effect of preclinical AD in genetic association studies of cognitive decline.
Further research is still needed with more rigorously designed studies , confirming effectiveness , feasible implementation , and scaling up of efficacious interventions.
Further research is suggested to investigate the causes and treatment of participation restriction.
Further research is to integrate MRI tests for a clinical tool to aid the diagnosis and intervention of brain aging.
Further research is warranted on an expanded concept of self-efficacy as well as controlled experimental studies on eating behavior in older adults.
Further research is warranted on the impact of environmental cadmium on breast cancer risk in specific populations and on identifying the underlying molecular mechanisms.
Further research is warranted on these important topics , as human population is continuously aging and becoming more obese.
Further research is warranted to consider the factors that might influence the perceptions of mental health across the life span.
Further research is warranted to determine its effects on other psychosocial outcomes and health care utilization in aging populations.
Further research is warranted to evaluate the relation between this MFS measurement and physical functional performance in those at high risk for falling.
Further research is warranted to identify barriers to and strategies for adequate mental health care for Korean immigrant elders.
Further research may explore the distinctive effects of JPA.
Further research might assess the LTL of elite athletes of varying ages compared with both age-matched active and inactive individuals.
Further research must integrate their studies with the biological , psychological , and social changes already associated with the aging process.
Further research of this role using longer sampling , in multiple sites and with economic analysis is recommended.
Further research on aetiological factors is needed.
Further research on explanations for the methodological differences is required.
Further research on how huddles affect resident care outcomes is needed.
Further research remains a prerequisite in order to further elucidate a possible common mechanism for ovarian and cardiovascular decline.
Further research should address more-detailed data collection and an explanation of the spatial patterns.
Further research should address the potential benefit of reducing of inappropriate polypharmacy and better pharmacotherapeutic management for preventing medication-associated frailty.
Further research should be conducted to examine the influence of body compartments on TSH levels through measuring total body water.
Further research should be directed at identifying feasible and effective ways to appropriately assess and manage these vulnerable patients at the primary care level.
Further research should confirm these changes in subjects over @number@ years.
Further research should elucidate reasons for geographic disparities in mental health care among racial / ethnic minority adults to reduce disparities.
Further research should explore the efficacy of recommended interventions.
Further research should focus on determining subgroups of caregivers who could benefit the most from case management.
Further research should focus on the high estrogen content of coffee as a plausible alternative explanation.
Further research to explore the relevance of left atrial structure and function in HF-pEF is warranted.
Further research using a more comprehensive cognitive test battery is needed to confirm the lack of association between high-frequency hearing and cognition.
Further research which develops specific methods for Thais might give better results for age estimation.
Further research will be necessary to establish whether LTL will ultimately be used in clinical settings as an index of healthy aging.
Further research will elucidate the role of stressors and help develop biomarkers to guide early management of AF.
Further research will help to understand how best practices are spread externally to other organizations.
Further research will ideally investigate longitudinal changes in telomeres and both these hormonal axes.
Further research with improved personal-level exposure assessment ( vs. residential exposure assessment only ) and phenotypic characterization is needed.
Further research with more recent data is needed to assess whether these results are statistical artifacts caused by data weaknesses in the NSFG.
Further research with this promising measure should focus on cross-national comparisons.
Further research would reveal the actual behavior involving OFE use and use's relationship to the physical activity of seniors.
Further results of our study will show if these circulating markers are related to the progression of AD.
Further review of COX inhibitors is required , especially toward the selectivity of coxibs and whether it directly inhibits prostacyclin synthase activity.
Further rigorous research is needed that includes adequately powered studies examining the critical components of the intervention and the dosage needed to have an effect.
Further , risk factors such as lack of exercise , stroke , arthritis , obesity , and malignancy differentially affect early retirement by gender.
Further , ROI and functional connectivity results suggest that these posterior regions function similarly during search and elaboration.
Further , Sadness may manifest in age-specific ways.
Further screening of unexplained cases for POGLUT1 identified six additional mutations , as well as two of the above described mutations.
Further , significant correlations were detected between hippocampal-dependent memory decline in AD participants and their ability to relive past and future events.
Further similar studies are needed to replicate our findings.
Further simulations evaluated the reliability of different constant stimuli protocols , varying both the range of dilutions and number of stimuli ( 6-16 ) .
Further , social structure shapes the availability of options for funding retirement.
Further , some age-related increases and decreases were observed for between-network correlations.
Further , specific markers for tendon cell differentiation declined and normal tendon architecture was disturbed , whereas pro-inflammatory molecules were upregulated.
Further , statistical analysis revealed the existence of a significant interaction between hopping frequency and age group on leg stiffness.
Further stratified analysis revealed a more significant association with MI risk among younger subjects ( ≤ @number@ years old ) .
Further strengthening the links between cell polarity and aging is a large number of common genes associated with both polarity and longevity.
Further structural optimization of @number@ is ongoing.
Further studies are necessary to evaluate the usefulness of the IlluminOss™ system in the in vivo augmentation of pedicle screws in the future.
Further studies are necessary to evaluate whether targeting microRNA-92a as microRNA mimics could be one of the therapeutic strategies in improving vaccine response in elderly.
Further studies are necessary to improve the implementation of the non drug strategies for the management of BPSDs.
Further studies are necessary to test the relationship with physical performance.
Further studies are needed for data of elderly trauma patients.
Further studies are needed in order to differentiate between the two illnesses.
Further studies are needed in representative populations that examine actual food intake on appearance , using validated tools in well-designed high-quality randomized control trials.
Further studies are needed on the frequency of these @number@ mutations in other sub-Saharan African populations.
Further studies are needed that examine the role of episodic memory in other executive function tasks in aging.
Further studies are needed to ascertain the benefits of statins on fatal MI , stroke and all-cause mortality.
Further studies are needed to assess current indicator , PP value , and the underlying mechanism of pain caused by sedentary lifestyle.
Further studies are needed to better understand the role of the hippocampus in the development and experience of depression in older adults.
Further studies are needed to characterize differences in metabolic response following ET among persons with diabetes.
Further studies are needed to clarify the active ingredients of these formulae and their target endogenous molecules implicated in the anti-dementia drug-like actions.
Further studies are needed to clarify the cause-effect relationship between lack of physical activity and malnutrition.
Further studies are needed to clarify the implications of altered HPA axis activity in older patients suffering from depression.
Further studies are needed to clarify the pathophysiology of digital ischemia in primary RP.
Further studies are needed to clarify the role of CMIs in AD.
Further studies are needed to clarify the temporal relationship between the emotional and nutritional domains in this vulnerable population.
Further studies are needed to clarify the utility of BTM reference intervals in the management of aging men at risk of osteoporosis.
Further studies are needed to confirm the association between NLR and delirium.
Further studies are needed to confirm these findings and to explore the underlying mechanisms and long-term cardiovascular consequences.
Further studies are needed to confirm these observations.
Further studies are needed to confirm whether hearing loss could be a non-motor feature of Parkinson's disease.
Further studies are needed to depict this major public health challenge.
Further studies are needed to determine if accumulated and continuous exercise have different chronic effects on insulin sensitivity.
Further studies are needed to determine the direction of causality.
Further studies are needed to determine the impact of TST on cardiovascular health.
Further studies are needed to determine the optimal antifungal strategy during remission-induction chemotherapy of ALL.
Further studies are needed to determine whether erythrocyte lifespan could provide a practical means of detecting subtle pre-clinical thrombosis.
Further studies are needed to determine which of these criteria is superior in predicting the risks of long-term vascular complications of diabetes.
Further studies are needed to differentiate and characterize functional subsets of local pulmonary and circulating T-cell populations in HIV-associated pulmonary dysfunction.
Further studies are needed to disentangle the mechanism behind the effects of each measurement of psychiatric conditions and how these are affected by educational level.
Further studies are needed to elucidate the cause of this relationship.
Further studies are needed to elucidate the complex relation between IGF-1 and late-life depression.
Further studies are needed to elucidate the pathogenic significance of identified variants in sporadic and familial ALS.
Further studies are needed to elucidate the potential biological mechanisms by which circulating klotho could affect longevity in humans.
Further studies are needed to elucidate this complex relation to improve the outcomes of frailty.
Further studies are needed to establish cut-points and treatment options with anti-inflammatory medications.
Further studies are needed to evaluate the clinical significance of this treatment modality.
Further studies are needed to evaluate whether the timely correction of MD using adequate dentures can increase the survival of older adults.
Further studies are needed to examine a wider range of coping resources among older adults.
Further studies are needed to examine in depth whether increasing levels of Sirt1 may serve as a potential therapeutic approach to treat or prevent retinopathy.
Further studies are needed to examine the effects of physical activity promotion and weight control interventions on preventing menopause symptoms in Korean women.
Further studies are needed to examine whether this effect would be mediated by the phenolics identified in this study.
Further studies are needed to explore alternate care pathways and promote more efficient use of health services.
Further studies are needed to fully interpret these findings and how to remedy disparities.
Further studies are needed to identify patients who may benefit from postoperative medication.
Further studies are needed to identify risk factors for anosmia and to investigate racial disparities in this sensory deficit.
Further studies are needed to investigate the future occurrence of metabolic diseases post-ADT.
Further studies are needed to investigate whether these changes explain the increased susceptibility to femoral neck fractures.
Further studies are needed to measure the impact of TREAT on re-admission rates , patient outcomes and satisfaction.
Further studies are needed to study the influence of pathologies on the studied parameters.
Further studies are needed to support these recommendations with the best possible evidence. < p > < em > J Drugs Dermatol.
Further studies are needed to understand the predictors and mechanisms of cognitive decline in DLB.
Further studies are needed to understand the underlying mechanisms of these findings.
Further studies are needed to validate and facilitate the application in clinic.
Further studies are needed to validate its diagnostic accuracy.
Further studies are needed to validate these preliminary data.
Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations.
Further studies are required to compare these models where risk stratification is different.
Further studies are required to determine if limbal changes affect stem cell viability.
Further studies are required to establish the therapeutic implications of inflammatory dysregulation in the pathophysiology of Parkinson's disease.
Further studies are required to evaluate the cardiovascular protective effects of lercanidipine / enalapril.
Further studies are required to examine different forms of health lifestyle in later life in relation to forms of cultural and economic capital.
Further studies are required to examine whether opportunities exist to intervene and improve outcome in this patient population.
Further studies are required with standardized protocols for ultrafine particle data collection in multiple European cities over extended study periods.
Further studies are still needed to investigate appropriate diagnostic criterion of sarcopenia for Chinese population.
Further studies are vital and should include care-recipient impairments and the quality of life of the person with dementia as additional outcomes.
Further studies are warranted to confirm these findings in a larger cohort of patients.
Further studies are warranted to elucidate whether the miRNA binding site SNPs are the causative variants for the observed risk effects.
Further studies are warranted to explore the possible gender-related association and to extend them to different populations.
Further studies are warranted to prove long-term outcomes.
Further studies are warranted to study the role of LTL dynamics in the pathogenesis of atherosclerosis.
Further studies are warranted to verify the role of ACO2 in AD pathogenesis and its importance as a marker of AD progression.
Further studies demonstrate that RecQL4 physically interacts with a major survival factor-survivin and its protein level affects survivin expression.
Further studies examining associations between dietary intakes of B-vitamins , biomarkers of B-vitamin status and cognitive endpoints are warranted.
Further studies for establishing of normal values of anorectal HRM in larger group of healthy controls are badly needed.
Further studies found that L-PHP was expressed in pancreas.
Further studies have described the distribution and etiology of neurodegenerative disease in the population , and determined pathological correlates of cognitive impairment and dementia.
Further studies have to investigate , whether BC-TEOAEs are more robust than AC-TEOAEs against small conductive hearing loss.
Further studies , however , are needed to confirm these associations , optimally in a clinical trial to confirm causality.
Further studies identifying the factors mediating the relationship between vision loss and mobility are needed to better understand how to improve mobility among AMD patients.
Further studies including a larger number of patients should be carried out to confirm these findings.
Further studies in diverse populations are needed to confirm this association and pinpoint mechanisms that may explain these results.
Further studies in ethnically distinct populations of patients with ET are necessary to understand whether genetic variability in SLC1A2 affects disease risk for ET.
Further studies in HEK293 / tau cells showed that Golgi-disturbing agents , brefeldin A and nocodazole induced tau hyperphosphorylation.
Further studies in this field are needed.
Further studies investigating protective alleles in populations with low AMD prevalence may lead to this goal.
Further studies investigating the mechanistic basis of the observed associations are needed.
Further studies need to elucidate a possible protective role and interplay between adiposity and skeletal muscle in older adults.
Further studies need to replicate these findings and examine mechanisms of these effects.
Further studies of rigorous design on HCC are recommended.
Further studies of the effect of cyclic stress on oxidation of remelted HXLPE are needed.
Further studies of VDR and its interaction with serum vitamin D levels are warranted to clarify the potential role of vitamin D in PD pathogenesis.
Further studies of αS in cerebrospinal fluid and blood would lead to establishment of the significance of αS as a biomarker for α-synucleinopathies including PD.
Further studies on cross-adaptation between chronic cold stress and heat tolerance are needed.
Further studies on laser toning are needed with the view to optimizing efficacy and minimizing side-effects.
Further studies on optimal risk prediction of future end-stage renal disease and effectiveness of any screening program are warranted.
Further studies on potential mechanisms of the correlates and optimal strategies to improve vitamin D status in this vulnerable subpopulation are warranted.
Further studies on the Aβ-dependent AD pathologies may contribute to determining novel mechanisms of AD development and new therapeutic targets in AD.
Further studies related to botulinum toxin resistance are needed.
Further studies revealed that ANRIL transcript EU741058.1 expression levels of rs10965215 and rs10738605 risk genotypes were borderline lower than those of protective genotypes.
Further studies should address the barriers encountered in improving quality of care in osteoporosis management.
Further studies should be completed to delineate the exact amount of cost-savings that can be obtained by proper implementation of glycemic control in the ICU.
Further studies should be conducted to determine whether improvements in prosthetic status can increase OHRQoL.
Further studies should compare indwelling time in different anatomical sites with phlebitis rate.
Further studies should confirm our results using prospective methods of collecting data.
Further studies should evaluate whether pre-operative physical training can improve post-operative outcome.
Further studies should examine optimal application amount and time to allow safe multipass facial rejuvenation without the need for invasive nerve blocks.
Further studies should help to better delineate SIAscopy as a prognostic tool.
Further studies should include traditional exercise as a control group to identify these potential , additional benefits.
Further studies suggested that HP may play a role as a complement to the defective endogenous antioxidant system to exert such lifespan elongation effects.
Further studies that are adequately powered and well-designed are warranted in an attempt to establish a causal relationship between vitamin D and frailty.
Further studies that include populations with low health literacy are needed before decisive claims can be made.
Further studies that include progressive strength and flexibility training are necessary to validate which FA exercise programs are most effective at preventing falls.
Further studies that meet the demanding criteria of a randomized clinical trial are urgently needed.
Further studies to detect the actual pathogenic variant / s are necessary.
Further studies to optimize therapy and to explore CARG GA as a toxicity predictor are vital.
Further studies using Drosophila should aid in the identification of factors that influence the frequency of somatic mtDNA mutations.
Further studies using large , representative samples and exploring decision-making incorporating health literacy and comorbidity are needed.
Further studies using more representative samples are needed to examine in detail the association between depressive symptoms and age in older cancer patients.
Further studies validating the cutpoints are warranted before using them in clinical settings.
Further studies will be conducted to identify more proteins and to demonstrate the interest of this method for cosmetic evaluations.
Further studies will be necessary to determine the validity and potential thrombotic and clinical implications of these findings.
Further studies will be needed for re-defining cut-off values in heart failure and maybe in the other chronic illnesses.
Further studies will be required to determine the detailed and specific molecular effects of these BMD-associated non-synonymous variants.
Further studies with a bigger sample size and longer follow up period are required to establish this association.
Further studies with larger numbers of participants , as well as validation of normal values , are needed for more definitive conclusions.
Further studies with larger samples are needed to confirm our results.
Further studies with population-based and longitudinal design should be conducted to confirm this finding.
Further studies with sufficient statistical power are needed to substantiate these inconclusive results.
Further studies would benefit from an expanded selection of diseases.
Further study demonstrated that glycolysis regulates H3T11 phosphorylation by fueling the substrate , phosphoenonylpyruvate and the coactivator , FBP to Pyk1.
Further study found that enhanced intracellular NAD ( + ) level could attenuate the aging phenotypes induced by NaDC3.
Further study is necessary to investigate whether BP is a potential modifiable risk factor for prevention of age-associated decline in muscle strength.
Further study is needed to better characterize the joint contribution of CRF and obesity on mortality in diverse populations.
Further study is needed to clarify whether estrogens plays a role in melanoma.
Further study is needed to determine the best model of orthogeriatric collaboration and if these partnerships improve functional outcomes.
Further study is needed to determine the role of pre-treatment identification of sexual function concerns in improving sexual outcomes associated with cancer diagnosis and treatment.
Further study is needed to establish the role of FIM as part of trauma scoring systems.
Further study is needed to evaluate effects of handrail cueing in a wide range of populations and real-life settings.
Further study is needed to identify effective strategies to improve dynamic muscle function in this population.
Further study is needed to validate this observation.
Further study is needed to verify the association between CAVI≥9 and MetS components.
Further study is required to determine whether there is any relationship between the age-related ASOCT findings of the TM interface shadow area and physiologic function.
Further study is required to evaluate the validity of these testosterone thresholds for CVD risk.
Further study is warranted to define the relationships between temperature , metabolism and circulation.
Further study is warranted to verify the effects of iron on bone metabolism.
Further study may elucidate mechanisms that explain these findings.
Further study might add easy items for assessing the performance of activity in real-life situations for patients with stroke.
Further study of determinants of these disparities is important.
Further study of interventions for reducing geriatric syndromes to maintain life satisfaction is required.
Further study of longitudinal interactions between vision and cognition is warranted.
Further study of the PLIÉ program in individuals with dementia is warranted.
Further study of the TERT-HCECs may be valuable in studying the function of the cells in vivo.
Further study of this aging population of Vietnamese Americans might help shed light on concerns faced by other refugee populations who have arrived more recently.
Further study of this relationship may help elucidate etiological factors in depression and targets for treatment.
Further study on the role of p66Shc will facilitate the research of novel disease-targetted drugs and slow down or cure age-related pathologies.
Further study should be conducted to validate these assessments with the goal of developing a comprehensive scale for measuring potential functional complications and risks.
Further study should be focused on screening and functional evaluation of the special species in the long-life residents.
Further study shows that DNA damage reduces steady-state mRNA level of ΔNp63α , but has little effect on its protein stability.
Further study will determine whether these factors can be used to identify patients at risk and to prevent prescribing and transcribing medication errors.
Further study will investigate genetic build up for the difference between chronological and biological aging.
Further study will need to verify the optimal practice trials in different populations with movement disorders.
Further study with well-defined entry criteria and uniform reporting of outcomes is needed to investigate the subject.
Further , supplementation with @number@ IU vitamin D3 per day does not appear to affect intramuscular IL-6 or TNFα gene expression after @number@ weeks.
Further support of weak ( \ "metric \ " ) measurement invariance was found across time.
Further , surface-based morphometry cortical volume was calculated in a subsample ( n = @number@ ) with structural MRI data.
Further surveillance , research , and intervention are needed to identify the causes of these changes and to reduce the incidence and mortality of CRC.
Further targeted proteomic and longitudinal studies would be required to validate these findings with more generalisability.
Further , TBI can act as a conduit to longer term neurodegenerative disorders.
Further testing in a more diverse and large sample is warranted.
Further testing is needed in a broader age range.
Further , TGFbeta @number@ and osteoprotegerin expression were enhanced in mandibuloacral dysplasia type A osteoblasts while the RANKL / osteoprotegerin ratio was diminished.
Further , the age-related differences in left FEF activation were a consequence of decreasing resting-state functional connectivity in visual sensory regions.
Further the Aging Male Symptoms ' scale ( AMS ) and the International Index of Erectile Function ( IIEF-5 and @number@ ) were scored.
Further , the antihip fracture efficacy shown in clinical trials is absent in real-life studies.
Further , the authors demonstrated age- and nonword-specific within- and between-session gains in speech motor performance.
Further , the bereaved group had a significantly higher cortisol : DHEAS ratio compared to controls ( p = 0.03 ) .
Further , the CC genotype moderated the relationship between the hippocampal cingulum and processing speed , though this did not survive multiple test correction.
Further , the change in basal MPS is positively associated ( r = @number@ p = @number@ ) with the change in muscle thickness.
Further , the ciPSCs required leukemia inhibitory factor and basic fibroblast growth factor to survive , proliferate , and maintain pluripotency.
Further , the deposition partitioning in the sub-regions of interest is different among the four models.
Further , the detection of oxidized-collagen peptides seems to be a promising approach for the diagnosis and the prognosis of inflammatory diseases.
Further , the differential age-related involvement of transcallosal pathways reported here raises new questions about the role of the CC in bimanual control.
Further , the dominant contributor to cortical volume reductions during adolescence was thinning.
Further , the external limiting membrane was continuous in the Ctrp5 + / - ; rd8 / rd8 and Wtrd8 / rd8 mice.
Further , the HCT-CI has been consolidated with various disease-specific and patient-specific risk factors to refine assignments of patients to the appropriate HCT setting.
Further , the IIV indices provided predictive utility above and beyond the TSS indices.
Further , the impact of the care structure on engagement and retention outcomes for YLHIV is ill defined.
Further , the majority of persons living alone with CI relied on adult children and paid professionals as the primary care providers.
Further , the MA-MCI groups showed lower baseline cognitive and functional performance and steeper cognitive decline compared with Control and SA-MCI group.
Further , the mechanical properties change differently in men and woman over lifetime.
Further , the neuropathological mechanism of risk appears to primarily involve amyloidogenic pathways.
Further theoretical conceptualizations and empirical studies are needed to determine how subjective aging contributes to health and survival.
Further , the overall quality of the results was achieved by a series of statistical methods , to avoid insignificant data in biological networks.
Further , the performance enhancement was related to an increase in the rate of hip moment generation.
Further , the proportion of NACT raised from @number@ to @number@ % irrespective of tumor subtype.
Further , the racial disparity in disability will disappear should the observed pattern of declining cohort-based ADL and IADL disparities persist.
Further , the rate of cognitive decline with aging is also different between the sexes.
Further , there appears to be sexual dimorphism with advancing age in the response of MPS to amino acid / insulin provision.
Further , there are linkages between the two diseases.
Further , the reflex SSNA response to a non-thermoregulatory stimulus was preserved in older adults during cooling.
Further , there is a growing body of evidence indicating a possible link between the logopenic phenotype and specific pathological and genetic correlates.
Further , there is an association between multiple medication usage and poor HRQOL , as well as a negative impact of cognitive impairment on HRQOL.
Further , there is consensus among geriatric clinicians and researchers that a group format for psychotherapy is likely especially helpful for the elderly.
Further , there is emerging evidence that various muscles may be affected differently by age-related changes in physical activity and movement patterns.
Further , there is increasing evidence that therapeutic radiation treatments can cause cardiovascular complications.
Further , the residents ' frames prove to be relativistic , which can be linked to their multitude of life experiences and complex emotional skills.
Further , the residents ' frames prove to be relativistic , which can be linked to their multitude of life experiences and complex emotional skills.
Further , the results confirm U.S. and European evidence that employer-provided pensions and health are significant determinants of retirement.
Further , the results of attribution-dissections in E1 indicated that @number@ factors ( rewarding and informational ) contributed to the palatability.
Further , there was no difference in the frequency of the disease-associated alleles , or cytokine levels between subjective memory complainers and noncomplainer participants.
Further , the salience of negative feedback seems reduced with age.
Further , these DRs have been hypothesized to put a constraint on the lifespan of mammals and are under a negative selection pressure.
Further , these patterns of functional connectivity have been shown to be altered in healthy controls under various physiological challenges.
Further , these studies demonstrate the ability of GRP78 to suppress oncogenic PI3K / AKT signaling.
Further , these training regimens are able to reduce the rate of sustaining injuries and falls in these age groups.
Further , these two defects may be related , as enforcing autophagy in CCM3-deficient late passage cells increases C / EBPβ cytokine expression.
Further , the valid agreement between kinematic models shows that such differences can be assessed by using just four body markers.
Further , the value of the γH2AX foci as a biomarker is depicted in x-ray irradiated lymphocytes of a healthy individual.
Further , the vast majority of HD patients reported at least one medical condition.
Further , the water diffusion in biological tissues appears biexponential , although this also has not been explored with aging.
Further , they appeared to be much adaptive as they had managed to overcome adversity and adapt successfully to major life changes.
Further , they validate its use on forensic cases , given the low error overall.
Further they were morphometrically and statistically analyzed with ImageJ and NCSS-PASS software.
Further , this fraction significantly reduced AGE-dependent monocyte chemoattractant protein-1 ( MCP-1 ) secretion from murine peritoneal macrophages.
Further , this methodology addresses essential gaps in understanding activity patterns and trends in more sedentary sectors of the population.
Further to animal studies , our group has observed an agerelated decrease in D-serine in the blood of healthy adults and elderly.
Further to examine whether any associations were similar by sex and health status.
Further to this finding , here we describe the functional effect of this mutation.
Further toxicity and clinical studies are warranted to establish more detailed data on crude extracts and pure compounds , enabling more convenient preparations for patients.
Further , trace amounts of CdCl2 inhibit mtDNA replication but suppresses MMS-induced mutagenesis.
Further treatment should consider chronobiological aspects to diagnose obesity and effectiveness of treatments.
Further , treatment with a sublethal dose of H₂O₂ was associated with an upregulation in the levels of VEGF and MMP-9.
Further , treatment with synthetic ET-1 enhanced fibronectin and collagen expression in P3 cardiac fibroblasts.
Further understanding of the causes of racial differences in capacity after stroke is needed to reduce activity limitations after stroke and decrease racial disparities.
Further understanding of the implications for long-term services and supports is needed.
Further understanding of these processes will help in the development of therapeutic strategies to increase healthspan and reduced the burden of age-associated diseases.
Further , urea stimulates oxidative stress and dysfunction in adipocytes , leading to insulin resistance.
Further useful information about correlation among the spinal features is acquired through factor analysis.
Further , using reverse regression we showed that the effects were present only in subjects with higher scores on the PAI-BOR.
Further validation in other cohorts is necessary.
Further validation in trials and clinical programmes is needed.
Further validation is required.
Further validations are crucial for the remaining suggestive loci including the emerged variant near OR10R3P / SPTA1.
Further , we acquired functional CBF and BOLD images simultaneously to examine their relationship during sensory stimulation.
Further , we assessed whether these graph metrics were affected in cognitively normal participants with cerebrospinal fluid evidence of preclinical AD.
Further , we decomposed the cohort-based disparity trends using Fairlie's decomposition method for nonlinear outcomes.
Further , we examined the interaction effect of social capital and social support.
Further , we examined the role that age of acquisition plays in modulating such responses.
Further , we focused on genetic screening of the TGFBR2 gene.
Further , we found that an aging-associated deficiency in response termination also is evident following TLR stimulation.
Further , we found that the degree to which older adults expressed decreased fusiform activity was related to worse performance on tasks of processing speed.
Further , we have proposed that the frailty index represents the biological age of the individual , and suggested an algorithm for its estimation.
Further , well-designed clinical studies are needed to confirm effectiveness and mode of action of HMB , particularly in pathological conditions.
Further well designed trials are justified.
Further , we observed a decrease in global CpG methylation.
Further , we show that DNA quality has an impact on TS ratios.
Further we show that mitochondrial DNA copy number was unchanged suggesting no change in steady-state numbers of mitochondria.
Further , we show that the aging lung is a relatively oxidized environment.
Further , we tested associations between cortical thickness and number of years since last cigarette , while controlling for lifetime smoking.
Further , we tested the role of cognitive functioning and social support in the association between arthritis pain and depressive symptoms.
Further , we use cross-sectional data to explore factors associated with activity profiles and prospective data to explore activity profiles and well-being outcomes.
Further , while all PHLPP proteins could be observed in the cytosolic fraction , only PHLPP1α could be localized to the nucleus.
Further work investigating mechanisms is needed.
Further work is also required to optimize the management of patients with minimal symptoms.
Further work is necessary to determine if these differences arise from differences in peripheral auditory function or in more central function.
Further work is needed to assess the generalisability of this Rasch score to other populations and to determine a clinically meaningful change score.
Further work is needed to better define the mechanisms by which ER stress facilitates progressive tissue fibrosis.
Further work is needed to determine whether domains become more or less distinct in severely cognitively compromised individuals.
Further work is needed to determine which older individuals will benefit from statins as primary prevention.
Further work is needed to establish what kinds of research are considered to be low risk.
Further work is needed to identify which patients may benefit from metformin for the prevention of dementia.
Further work is needed to refine the approach to smokers with normal lung age.
Further work is needed to study their role in AAA destabilization and weakening.
Further work is needed to test the scale in diversified samples.
Further work is needed to understand CML's value as a risk stratifier , biomarker , or target for interventions that promote healthy aging.
Further work is required for measurement generalization.
Further work is required , however , to determine the significance of PD-MCI and also to validate the diagnostic criteria.
Further work is required to corroborate our findings on other samples and investigate the underlying mechanisms of brain iron accumulation.
Further work is required to establish which is the most suitable scales for this application.
Further work is required to understand what impact sleep disturbance has on frailty levels and poor outcomes in older critically ill patients.
Further work should address possible mechanistic interpretations in humans.
Further work should investigate whether addressing home hazards is an effective intervention for preventing falls in this high-risk group.
Fused in sarcoma ( FUS ) and splicing factor , proline- and glutamine-rich ( SFPQ ) are RNA binding proteins that regulate RNA metabolism.
FUS exposure with microbubbles was delivered to open the BBB of nude mice that were either normal or implanted with U87 human glioma cells.
Fusiform FA and temporal lobe MD were significantly related to total MoCA score after accounting for age and education.
Fusing multivariate statistical approaches with network science presents the best path to develop these methods.
Fusion explained a statistically significant but small proportion of the total variance.
Fusion of acromial primary and secondary ossification centers began at age @number@ and was generally complete after age @number@
Fusobacterium nucleatum is an important periodontal pathogen involved in the development of bacterial complexity in dental plaque biofilms.
Future ACP interventions should consider incorporating these additional ACP activities.
Future adequately powered RCTs are required to confirm / refute these findings.
Future analyses of these data are needed to elucidate the sense of smell's role in physical , social , and mental health with aging.
Future analyses will evaluate whether SDBOLD is modifiable with interventions aimed to increase PA and CRF in older adults.
Future animal work needs to investigate sex differences in rodent mutants modeling autism-relevant genes and environmental exposures.
Future challenges are related to the intelligence of the systems and making the technologies even more unobtrusive and intuitive.
Future characterization of interleukin-6 regulation networks may facilitate the identification of additional potential targets for treating inflammation-related diseases.
Future clinical applications will focus on monitoring response to cancer therapy , whereas tumor detection will be limited to organs with high physiologic 18F-FDG uptake.
Future cohort studies are warranted to clarify the causal correlation.
Future collaborations will collect prospective data to identify relationships between each of these syndromes and specific biomarkers for a more detailed understanding of clinicopathologic correlations.
Future confirmatory studies are needed.
Future controlled trials are indicated to examine the effects of incorporating these foods into multimodal weight loss interventions.
Future days of desired life were related to prospective health condition , fear of death , negative affect , and trust in prison health care.
Future declines in smoking may be driven even more by the aging of the population and increasing racial and ethnic diversity.
FUTURE DIRECTIONS : A better understanding of Ca ( 2 + ) signaling and molecular aging alterations is important for preventing apoptosis in age-related diseases.
FUTURE DIRECTIONS : A deeper understanding of the roles of Msrs in redox signaling , the aging process , and metabolism will be achieved.
FUTURE DIRECTIONS : Currently , hundreds of potential SIRT3 and SIRT5 molecular targets have been identified in proteomic experiments.
FUTURE DIRECTIONS : Elucidation of additional transnitrosylation cascades will further our understanding of the enzymes that catalyze nitrosation , thereby contributing to NO-mediated signaling pathways.
Future directions for research on perceptions of aging are suggested.
Future directions for testing hypotheses generated from this model are presented.
Future directions for the extraction and purification of beneficial constituents are also discussed.
FUTURE DIRECTIONS : Here , we review evolving functions of Nox enzymes in normal lung physiology and emerging pathophysiologic roles in lung disease.
Future directions include longitudinal studies to determine if circulating microRNAs are predictive of response to behavioral interventions.
Future directions in the study of health behavior among older adults are discussed.
FUTURE DIRECTIONS : Mitochondria and their functions can be targeted with the aim of improving skeletal muscle insulin sensitivity and cardiac function.
Future economic evaluations of falls prevention interventions remain necessary and should consider the NBRF so that regression tools can facilitate cost-effectiveness analysis.
Future efforts to more completely characterize patient health status before transplantation will allow better application of HCT in older adults.
Future efforts to understand asthma in the elderly must include geriatric-specific methodology to diagnose , characterize , monitor , and treat their disease.
Future focused survey of sequence elements containing mainly functional and regulatory variants may yield additional findings.
Future functional studies would be needed to evaluate the pathogenicity of this mutation in AD.
Future ( human ) studies are needed which take the concept suggested here of the MediterrAsian diet into account.
Future human studies should address the appropriate dose range and low bioavailability of resveratrol.
Future implications include further investigation into strictly older cancer patient populations , as outcomes related to exercise might differ between older and middle-aged adults.
Future incidence rates are estimated to increase within aging societies.
Future initiatives should address remaining challenges in ensuring access to care for all children in underserved communities.
Future initiatives should prioritize improved provider engagement and accurate information dissemination in Web-based venues.
Future integration of psychiatric and general medical healthcare , especially outpatient care , might further optimize health outcomes for older adults with schizophrenia.
Future interdisciplinary work such as this may enhance our capabilities to understand more about the processes involved in influencing change in attitudes and behaviors.
Future interventional research should investigate the combination of both physical and cognitive training to prevent decline of physical function in older adults.
Future intervention research with African Americans should test whether explicitly targeting external locus of control leads to greater cognitive improvement following cognitive training.
Future interventions may be warranted , and research should focus on optimal serum TC , HDL-C : TC ratio and TC change trajectories.
Future interventions should nevertheless target older individuals who stop physical activity and those who remain inactive to lessen the risk of depression.
Future intervention studies could attempt to challenge negative SPA to support effective strategy use in older adults with serious illnesses.
Future investigation into response phenotypes is warranted using pathway analyses , or newer genetic technologies such as metabolomics.
Future investigation of the effect of current ABT policies on crash rates and the potential to use other scientifically designed ABT strategies is therefore needed.
Future investigation of the metabolic and structural properties of these fat compartments will help us understand the different patterns of volumetric facial aging.
Future investigations are required to determine the relationship of these changes in adrenal function to symptoms and health outcomes of mid-aged women.
Future investigations are warranted to determine the physiological mechanisms linking strength gains and cognitive benefits.
Future investigations are warranted to evaluate the potential impact of prevention and treatment of unfavorable arterial hemodynamics on neurocognitive outcomes.
Future investigations are warranted to optimize TMS methodologies for this purpose.
Future investigations targeting the long-term effects of insulin and leptin treatment may reveal evidence to reduce risk of cognitive decline and Alzheimer disease.
Future investigations will be necessary to address possible confounding factors and confirm these results.
Future investigations will primarily be large , phase @number@ studies that will assess the utility of amyloid PET imaging in routine clinical practice.
Future in vivo validation of these results awaits comprehensive biomarkers of these @number@ brain diseases.
Future knowledge of the impacts of multiple comorbidities on post-HCT toxicities might guide new prophylactic and therapeutic interventions to lessen the procedure's mortality.
Future larger studies will be needed to examine associations between epigenetic age acceleration and cumulative hormone exposure.
Future large-scale and rigorously designed trials are needed to confirm our findings.
Future large-scale longitudinal studies are necessary to confirm these findings and assist in the development of preventive interventions in vulnerable individuals.
Future large well-designed clinical trials are needed in order to further investigate the potential of these agents as dermatological therapies.
Future lifestyle interventions should be of a longer duration and include a nutrition component.
Future longer-term studies with objective sleep measures are needed to corroborate these results.
Future longitudinal analyses are needed to explain the temporal relationship between these conditions and how they relate to other aspects of impairment and physical function.
Future longitudinal and experimental studies are needed to reveal the mechanism and clinical consequences of these associations.
Future longitudinal and histological investigations are necessary to improve the accuracy of models of reproductive aging.
Future longitudinal research is needed to elucidate the mechanisms that underlie the association between CVH and LTL.
Future longitudinal research is needed to understand risk / protective factors associated with health literacy level in Chinese older adults.
Future longitudinal research is required to confirm / refute these findings.
Future longitudinal research should confirm the current findings.
Future longitudinal studies are deemed necessary in order to obtain consistent results.
Future longitudinal studies are needed to confirm these associations.
Future longitudinal studies are needed to explore the causal relationship between social support and cancer screening use.
Future longitudinal studies are needed to improve our understanding of the risk factors and outcomes associated with discrimination among U.S. Chinese older adults.
Future longitudinal studies are needed to quantify the risk and protective factors associated with EM in Chinese aging populations.
Future longitudinal studies are needed to quantify the temporal association between filial piety and suicidal ideation.
Future longitudinal studies are needed to validate the findings of the present cross-sectional study and to better understand the nature of this relationship.
Future longitudinal studies of large numbers of professional football players are needed to support the findings from this study.
Future longitudinal studies should be conducted.
Future longitudinal studies should be conducted to better understand the risk and protective factors associated with medical conditions.
Future longitudinal studies should examine other potential neuroprogressive pathways such as inflammation , mitochondrial dysfunction , serum anticholinergic burden , and altered neurogenesis.
Future longitudinal studies should examine the pathophysiologic significance of the shift from MTL hyper- to hypometabolism associated with IR.
Future management will likely focus on intervening earlier to prevent accelerated vascular aging and irreversible arterial damage.
Future needs in dementia research and healthcare research are presented.
Future network-based research might enable indentification of different stages of disorders , subtypes for cognitive impairment , and connectivity profiles associated with different clinical outcomes.
Future patient-centered and multidisciplinary interventions should be developed and tested using evidence-based principles to improve medication adherence and health outcomes in older adults.
Future placebo-controlled research is required to confirm our results.
Future plans were positive , but vague , and worries about the future were prevalent.
Future projects will examine this model using simplified screening procedures.
Future projects will need both front-level staff commitment and prolonged high-level leadership involvement to thrive.
Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery.
Future psychometric studies of the AMS scale should report important characteristics of the participants , details of item scores , and test-retest reliability.
Future public health efforts may be able to leverage social support to reduce health disparities and improve mental and physical functioning.
Future quantitative gait studies may help distinguish dementia subtypes in early stages of the diseases.
Future randomized controlled trials are warranted to investigate whether screening and managing masked hypertension could reduce cardiovascular events in diabetic patients.
Future randomized control trials are required to support that the diagnosis and monitoring of vascular aging-related hypertension is best managed with the central BP strategy.
Future research can assist in developing recommendations which can minimize these risks in the elderly patient demographic.
Future research could also seek the opinions of staff about the impact of the environment on them as well as residents.
Future research could determine the relationship between activity levels and patient outcomes.
Future research could focus on developing personalised treatment programs for older adults with sleep complaints.
Future research directions for the use of androgens in the treatment of frailty are suggested.
Future research directions include treatment studies for perceived burdensomeness as a way to reduce suicide ideation.
Future research efforts are likely to focus on nutrient and energy sensing molecular pathways which include mTOR , IGF-1 , AMPK and the sirtuins.
Future researches need to address the exact dynamics of detrusor contraction and the muscular and neurological contributors to UAB.
Future research exploring neurobiologic evidence for neurodegenerative processes in BD will pave the way for potential therapeutic interventions.
Future research exploring strategies to increase the promotion of these services to older samples may further improve their perceptions and use.
Future research , however , is needed to further examine the importance of these social processes and their effects on depression.
Future research is needed to address factors that stabilize health and reduce stress among a racially diverse , aging prison population.
Future research is needed to better promote shared decision-making among persons with dementia and their family carers.
Future research is needed to better understand patient-centred outcomes of transfer and to explore alternative models of emergency healthcare.
Future research is needed to clarify the prognostic role of ferritin.
Future research is needed to clarify which patients benefit most from each treatment modality.
Future research is needed to confirm our results in other populations and to explore potential mechanism underlying the observed association.
Future research is needed to confirm these findings.
Future research is needed to determine whether these novel interventions will be successful in preventing sarcopenia and improving muscle strength and function in older adults.
Future research is needed to establish whether gender reliably moderates this association.
Future research is needed to examine risk and protective factors associated with elder self-neglect.
Future research is needed to examine whether interventions focused on maintaining or enhancing psychological well-being could minimize later life declines in sleep quality.
Future research is needed to explore model application for informing treatment approaches during early intervention.
Future research is needed to identify modifiable environmental exposures that amplify or mitigate genetic risk for elevated BMI.
Future research is needed to identify the psychological and sociocultural profiles of individuals who show stress resilience and those who are vulnerable.
Future research is needed to improve access to CHCs and promote their use in urbanised populations with low to modest education.
Future research is needed to investigate the basis of this association and whether hearing rehabilitative interventions could affect physical activity in older adults.
Future research is needed to investigate the physiological mechanisms responsible for the variability in pain qualities endorsed by older adults.
Future research is needed to understand how obesity differentially alters serum and RBC folate status because they are associated with a variety of medical complications.
Future research is needed , with a focused approach to understand the molecular targets , cellular effectors , and receptors.
Future research is now needed to examine these associations with respect to objective sleep measures and overnight memory consolidation.
Future research is required to investigate VOL predictors and the potential changes toward the end of the life span.
Future research is still needed to improve the understanding and management of ACOS.
Future research may examine the moderating effects of baseline depression severity and identify other clinical or demographic moderators.
Future research may facilitate safer living in space by reducing the adverse effects of oxidative stress.
Future research may have important implications for the survival of prostate cancer patients and the identification of new and safe hot flash treatments.
Future research must further elucidate the correlation between noncognitive changes and distinct dementia subtypes.
Future research must target community-dwelling dementia patients and take a holistic approach to medicines management.
Future research needs in the field are also highlighted.
Future research needs to focus on the generation of \ "safe \ " as well as viable hiPS-derived somatic cells.
Future research on Delphinol® and delphinidins may be expected to identify further health benefits.
Future research on lipid-lowering drugs and cognition is needed ; careful study design and analysis will be critical.
Future research on need for LTSS should focus on projections of need , geographic variations , equity , and unmet needs of consumers and caregivers.
Future research on pharmaceutical therapies for counteracting sarcopenia should consider non-pharmaceutical therapies and also the causes of sarcopenia.
Future research on the optimal tools to characterize physiologic age and appropriate interventions in the context of transplant are needed.
Future research regarding the role of androgens in the development of CVD and potential modulatory effects of BMI is required.
Future research should address the appropriate introduction , teaching , and support required for people living with dementia or MCI to use the motion-based technology.
Future research should address the causality of associations between low grade inflammatory processes and cognitive functioning.
Future research should address the potential link between fertility knowledge and planning of parenthood.
Future research should aim to inform the development and use of maximally effective and valid proxy measures of functional ability.
Future research should aim to select and / or adapt existing scales to identify the ' best ' to improve clinical research and practice.
Future research should attempt to ascertain a person's degree of interest in stimuli prior to developing an intervention.
Future research should characterize the lipoprotein particle size in this population.
Future research should consider the inclusion of everyday cognitive measures in functional assessment batteries.
Future research should consider the role psychotropic medications have in coping with social isolation and loneliness among older adults.
Future research should continue to focus on developing better predictive models.
Future research should employ theoretically grounded concepts , use multivariate analysis and longitudinal designs.
Future research should evaluate survival and differences in metabolic profile in patients with diabetes and different dementia disorders.
Future research should examine changes in serum uric acid at earlier periods in the lifespan and their relationships with later cognitive declines.
Future research should examine other motives for drinking in older adulthood.
Future research should examine possible pathways and routes of intervention to improve mental health among older adults.
Future research should examine the association between hospice enrollment and the quality of end-of-life care.
Future research should examine the behavioural mechanisms by which these risks are mediated to optimize cardiovascular health.
Future research should examine the efficacy of PEP for improving other CVD biomarkers and seek to sustain the intervention's effects.
Future research should examine the generalization of these findings to rural male older adults.
Future research should examine the inter-relationships of allostatic load , psychological stress , and late-life depressive symptoms.
Future research should examine the necessity of including gait speed in algorithms and the validity of cut-off values.
Future research should examine the relationship between perceived financial preparedness and actual savings.
Future research should examine whether ethnic differences in β-cell physiology contribute to disparities in T2D risk.
Future research should examine whether the significance of social engagement among poor elders applies in less-developed and developed countries.
Future research should explore the association between incarceration status and markers of aging including mortality , morbidity and physical appearance.
Future research should focus on determinants of long term health effects of ANM , and efforts to improve women's postmenopausal health and quality of life.
Future research should focus on interventions designed to assure timely access to those bereaved family caregivers who are most in need.
Future research should focus on the interaction between ( disturbed ) cholesterol homeostasis and ApoE e4 status with respect to dementia.
Future research should focus on the mechanisms by which healthcare discrimination influences disability in older adults to promote better health outcomes for an aging population.
Future research should further evaluate whether the aforementioned characteristics are associated with longevity beyond the average life expectancy.
Future research should further examine whether the underlying reason for this age difference is rooted in age-related improvements in emotion regulation.
Future research should identify the precise neurophysiological impairments that contribute to declines in neuromuscular activation rate and mobility function with aging.
Future research should include different conditions for gait to determine adaptive potentials of older adults.
Future research should include longitudinal studies to consider variable risk factors , such as military service , smoking , and so on.
Future research should incorporate additional factors that may better model the relationships between health literacy , knowledge , self-efficacy , and self-care.
Future research should investigate if SOPT transfers to improvements in the everyday functioning of those with MCI.
Future research should investigate other potential resilience mechanisms among African Americans to explain their relatively positive mental health outcomes.
Future research should investigate potential pathways through which these specific SES indicators influence dietary adherence.
Future research should investigate the mechanisms behind transfer effects to real-world activities , such as driving.
Future research should investigate the reasons behind the motives of low socio-economic position and obese older adults.
Future research should prospectively examine frailty's causal connection with anorexia of aging.
Future research should provide insight about specific aspects of coping and other personal characteristics that facilitate and limit the effect of coping on hypertension.
Future research should replicate findings with objective activity measures.
Future research should replicate the current findings with an increased sample size and the development of tailored interventions for each body composition category.
Future research should target the role that SHS exposure may have in nicotine dependence , cessation outcomes and other health impacts among smokers.
Future research should test the proposed causal sequence using longitudinal data with at least @number@ waves.
Future research should use these memory trajectory phenotypes to determine whether dementia risk and protective factors differ for individuals following different memory trajectories.
Future research should validate this index in other ICU settings , assess its predictive validity , and evaluate different methods for maximizing response rate.
Future research targeting inflammation should examine these pathways.
Future research will explore possible validity of this etiological model for SCH and BD.
Future research will focus on how the tool influences discharge decision-making and how its accuracy can be improved in specific settings.
Future research will focus on identifying the underlying biomolecular mechanisms , with the aim to promote health in old age.
Future research will focus on the identification of markers for the diagnosis of preclinical auditory aging and the development of effective interventions.
Future research would benefit from repeating these analyses in a larger sample and also including a younger comparison group.
Future research would benefit from using CCA to understand how various psychobiological constructs predict fall-related outcomes.
Future sequencing efforts with larger sample sizes and more comprehensive genome coverage are anticipated to identify additional AF-related variants.
Future studies aimed at combining cohorts with echocardiographic phenotypes need to be conducted to identify genetic variants associated with valvular calcification.
Future studies applying UCM analysis should examine if experimental set-ups limit movement exploration , leaving possible age differences undetected.
Future studies approaching the NF1 cognitive profile might benefit from looking at the mechanisms linked to the age-related aspects of cognitive decline.
Future studies are necessary , utilizing a standard self-medication criterion to facilitate comparison and elucidate the factors associated with this behaviour.
Future studies are necessary with an aim to improve and optimize care of frail older people.
Future studies are needed in order to prevent the origin and reduce the incidence and consequences of developmental programmed diseases.
Future studies are needed to assess the individual associations of lutein and zeaxanthin in eye health.
Future studies are needed to assess the longer-term consequences of such training and the impact on affect and wellbeing in more vulnerable groups.
Future studies are needed to clarify mechanisms underlying vitamin Ks role in OA.
Future studies are needed to clarify the clinical significance of the complications encountered in elderly patients treated with rhBMP-2.
Future studies are needed to confirm our findings and to elucidate a plausible biological mechanism.
Future studies are needed to determine optimal pharmacologic treatment of hyperglycemia in this population.
Future studies are needed to determine the factors contributing to differences in the associations observed.
Future studies are needed to determine whether factors such as socioeconomic status explain associations between reproductive events and longevity.
Future studies are needed to distinguish everyday life conflict from acculturation-related conflict in this population.
Future studies are needed to effectively answer this question for the better care of HIV-infected elderly patients.
Future studies are needed to elucidate the causal mechanisms linking limitations in physical function with dementia risk.
Future studies are needed to elucidate the pathogenesis of T1DM-related cognitive impairments or dementia.
Future studies are needed to examine intervention effectiveness , scalability , and durability of observed outcome effects.
Future studies are needed to examine the effects of anatabine on naturally-occurring inflammation that is common with aging or obesity.
Future studies are needed to examine the temporality of these associations.
Future studies are needed to further understand whether successful pain management may significantly improve both brain health and mobility.
Future studies are needed to help confirm these findings.
Future studies are needed to identify possible race-related protective factors against clinical expression of TDP-43 proteinopathies.
Future studies are needed to investigate possible reasons for the racial / ethnic group differences.
Future studies are needed to study implementation of this intervention into routine clinical care within ADHC.
Future studies are needed to validate these findings in appropriate animal models so new therapeutic targets can be identified for treatment of dry AMD.
Future studies are warranted to establish the validity of these proteins as prognostic factors for cognitive decline.
Future studies are warranted to explore the predictors of LVDD and HFpEF in the community elderly.
Future studies are warranted to investigate the role of exercise in risk factor reduction for primary and secondary prevention of stroke in people with DS.
Future studies are warranted to test the significance of our findings.
Future studies can explore the role of MnSOD in age-related illness using this new mechanism of enzymatic regulation.
Future studies confirming the present findings are required to further demonstrate the beneficial effects of memantine on the DMN in Alzheimer's disease.
Future studies could aim to discover the particular set of genes that underlie the significant heritability of white matter microstructure.
Future studies could focus on protective factors that promote caregivers ' resilience.
Future studies elucidating the impacts of long-term or successful treatment history of sleep apnea on the maintenance of LTL are warranted.
Future studies examining all antioxidants in the diet in relation to age-related cataract are needed to confirm or refute our findings.
Future studies in older adults with diabetes are warranted to examine the neuroprotective effect of PA in these networks.
Future studies into the pathophysiological mechanisms may guide the development of new treatment opportunities for these vulnerable patients.
Future studies , looking at the effect of several / consecutive TENS and tDCS sessions should be conducted.
Future studies may address the role of drugs for specific elements of delirium.
Future studies may identify the concomitant roles genetics and exercise play in neuroprotection.
Future studies may report antibiotic use by infection type and stage of dementia , and compare cross-nationally.
Future studies may use these measures to investigate within-person and between-medication differences in adherence.
Future studies need to assess whether increasing the frequency or the number of CR sessions leads to significant improvement in cognition.
Future studies need to follow these interactions longitudinally to understand potential causal relationships.
Future studies need to tailor interventions for hypertension management in old age.
Future studies need to understand how structural reorganization enables long-term recovery even when the brain is shrinking.
Future studies of gene-environment interplay in depression may benefit from focus on genetics discovered for putative protective factors.
Future studies of RCTs for non-pharmacological interventions targeting MCI related to AD may benefit by addressing design limitations.
Future studies on genetic modifiers in FTD are warranted.
Future studies on obesity-related functional and structural brain changes should therefore account for sex-related differences.
Future studies recruiting a larger number of women are needed to replicate the findings.
Future studies should address whether dogs with asymptomatic valve disease are at higher risk for subsequent morbidity or early death.
Future studies should aim to assess these exposures in relation to subtypes of male breast cancer.
Future studies should aim to compare predictive strengths of markers between early-stage and late-stage MCI patients.
Future studies should also examine the duration of effects in relation to the overall duration of treatment and the number of sessions.
Future studies should assess the benefits and feasibility of power- and velocity-oriented training in patients with osteoarthritis.
Future studies should assess the longitudinal associations between falls and physical activity.
Future studies should assess whether other biomarkers show similar trends and potential mechanisms for unanticipated sCD14 and D-dimer findings.
Future studies should attempt to replicate our findings in a larger cohort.
Future studies should be aimed at determining if this biological variation is predictive of developmental adversity.
Future studies should be aimed at testing the possible benefits produced by multidomain interventions on frailty.
Future studies should confirm these effects over a more prolonged training period.
Future studies should confirm these results.
Future studies should consider how specific gardening interventions help older adults meet physical activity guidelines.
Future studies should consider whether these metabolites are relevant for metabolic disease processes.
Future studies should determine whether measurement of IL-6 and CRP could enhance current methods of monitoring respiratory diseases beyond that provided by pulmonary function measures.
Future studies should evaluate reasons for these differences in the prognostic importance of individual kidney injury markers.
Future studies should evaluate strategies to maintain or improve cognitive function.
Future studies should evaluate the applicability of this approach to other teams / tools.
Future studies should evaluate whether Medicaid HCBS waiver programs are effective in promoting community-living among low-care residents and mitigating the growth in long-term care expenditures.
Future studies should examine genetic risk prediction in assessing the risk of cervical neoplasia further , in combination with other screening methods.
Future studies should examine these trends across the entire lifespan.
Future studies should examine what degree of ABPV is harmful and if control of ABPV reduces adverse outcome.
Future studies should examine whether HIV-infected adults over @number@ evidence accelerated aging in downstream neurocognitive domains and subsequent everyday functioning outcomes.
Future studies should examine whether low 24-hour DBP and lack of nighttime systolic dipping predict future cognitive impairment.
Future studies should examine whether maintaining higher RBC EPA + DHA levels slows the rate of hippocampal or overall brain atrophy.
Future studies should explore associations between changes in HRQOL before and after cancer diagnosis and OS.
Future studies should explore if better glycemic control can preserve muscle function in diabetes.
Future studies should explore mechanisms to explain this relationship.
Future studies should explore routine screening for clinical frailty in critically ill patients of all ages.
Future studies should focus on MPH specifically to adequately asses its benefits in relation to the risks specific to this drug.
Future studies should focus on the development of evidence-based guidelines for diagnosis and the pharmacological therapy of asthma in the elderly , including late-onset asthma.
Future studies should focus on these aspects.
Future studies should focus on understanding the mechanical properties of joint crystals and developing methods to understand how crystals affect chondrocyte mechanotransduction.
Future studies should include a larger sample size to detect any differences between ROC training and conventional therapy.
Future studies should include larger examinations of these associations and consider the potential usefulness of these glycoproteins as biomarkers for frailty.
Future studies should include tests of alternative service delivery models and development of participation-level outcome measures.
Future studies should incorporate bootstrap-derived metrics to provide more comprehensive analysis.
Future studies should investigate a variety of cognitive tasks to determine the degree of postural improvement that can be observed in older adults.
Future studies should investigate how aging modifies genotypes ' contributions on PD risk and sequelae.
Future studies should investigate mechanisms through which klotho may affect domain-specific cognitive changes.
Future studies should investigate the impact of patterns of sedentary time on healthy aging , disease , and mortality.
Future studies should investigate the neural substrates of learning deficits in SCZ and BD , particularly focusing on hippocampus function and glutamatergic transmission.
Future studies should investigate the role of nonvascular mechanisms linking DS and cognitive decline.
Future studies should investigate whether the MCR subtypes predict different subtypes of dementia.
Future studies should investigate whether these two groups of individuals share the views of the patient and the designated proxy on anticipated HRQoL.
Future studies should investigate why resilience moderates associations between community belonging and social participation , and how to enhance resilience among older adults.
Future studies should investigate why these differences exist and ways to reduce them.
Future studies should prospectively investigate whether HIV interacts with BP to further increase AMI risk.
Future studies should seek to elucidate contributing factors of adherence among older individuals with HIV.
Future studies should take this into account.
Future studies should test whether therapies that attenuate cardiovascular risk in HIV favorably impact bone health.
Future studies should thus be designed to specifically explore the properties of primate-specific genes.
Future studies should use longitudinal fMRI to examine the developmental trajectory of the neural circuitry mediating response flexibility in BD.
Future studies that include QOL measurements should also provide details on the data collection and quality control methodologies used.
Future studies that may test some of these potential mechanisms of bilingual CR effects are proposed.
Future studies to elucidate how these proteins function in telomere protection might benefit patients suffering aging or cancer who are not sensitive to telomerase mediation.
Future studies using standardized techniques and larger patient numbers are awaited to realise the full potential of αS as a more definitive diagnostic biomarker.
Future studies using this animal model should further our understanding of the role of the hippocampus in memory maintenance and updating during normal aging.
Future studies , which include hormonal assessments , are needed to confirm these preliminary findings.
Future studies will help to determine if the Klotho protein regulates cell-surface expression of other transport proteins and is affecting underlying mechanisms.
Future studies will need to determine if follow-up booster sessions increase long-term efficacy.
Future studies will need to determine whether this is representative of the normal aging process or an early indicator of neurodegeneration.
Future studies will need to validate the major targets of these enzymes , and elucidate how acetylation and / or acylation modulate their functionality.
Future studies with greater sample size should be completed to replicate and extend these findings.
Future studies with larger samples are needed to confirm these preliminary findings.
Future studies with larger sample sizes are needed to confirm these findings.
Future studies with larger samples will be needed for further validation and to allow the analysis of other psychometric properties.
Future studies would require the analysis of larger , relatively inbred data sets that might reveal novel recessive AD genes.
Future study design concerning CIMT in separation groups of men and women , so as Lt and Rt is highly recommended.
Future study is needed to evaluate the difference in the risk of adverse outcomes associated with various levels of anticholinergic burden.
Future suicide-prevention programs should emphasize the role of depression in suicide among older people.
Future systematic studies addressing these issues will greatly expand our knowledge of neural connections and dynamics related to mental disorders.
Future therapeutic efforts may benefit from the development of models that enable basic investigation of early disease pathology.
Future training protocols for VTF should take into consideration the effect of aging.
Future trials need to assess vascular and molecular changes in women with OAB.
Future work aimed at improving physical capacity , reducing depressive and anxiety symptoms , and improving aphasia / dysarthria has potential to enhance participation.
Future work includes further improvements of the model.
Future work is needed to determine whether a decrease in postural sway complexity could predict future decline in physical function in these women.
Future work is needed to determine whether modifications in physical activity levels can improve or preserve physical performance in later life.
Future work is needed to further examine the peripheral and central mechanisms underlying this relationship and to test whether enhancing coordination alters mobility limitations.
Future work on larger APOE e4 allele carrying samples is required to determine the nature of the association in this population.
Future work should address complexities of these relationships in order to better understand rapidly changing family structures.
Future work should evaluate the interaction between VEGF expression in vitro and pathologic burden to address potential mechanisms.
Future work should examine how cerebral amyloid angiopathy interacts with neurodegenerative processes , such as Alzheimer's disease.
Future work should examine individual or neighborhood predictors of MOVES and its relationship to broader health outcomes.
Future work should examine interventions aimed at preventing declines in strength in older adults with impaired nerve function.
Future work should examine the responsiveness of these measures when individuals with balance disorders participate in rehabilitation.
Future work should explore whether dual-task training under visual challenge could reduce cognitive-motor interference and reduce fall risks in older adults.
Future work should focus on more inclusive models of that better define \ "normal \ " vs \ "pathological \ " aging.
Future work understanding the determinants of these differences has the potential to improve the overall efficiency and equity of national health systems.
Future work will assess the validity of these models using medical record data.
Future work would benefit from strategies specifically designed to reduce and prevent acute hospitalizations in persons with dementia.
FVC% , FEV1% , PEF% values was decrease.
FV over limb muscles modulates neurophysiological oscillations enhancing excitability of contralateral S1-M1 in healthy volunteers.
G1 attended educational lectures once a week , whereas G2 walked three times a week.
G3BP2 induces both cell cycle progression and blocks apoptosis.
G3BP2 knockdown results in reduced tumor growth and increased nuclear p53 accumulation in mouse xenograft models of prostate cancer with or without long-term androgen deprivation.
G4 DNA has been implicated in several biological processes , but tools to study G4 DNA structures in cells are limited.
G6PD deficiency has been the most pervasive inherited disorder in the world since having been discovered.
G6PD has an antioxidant role by functioning as a major nicotinamide adenine dinucleotide phosphate ( NADPH ) provider to reduce excessive oxidative stress.
G6PD may play an important role in embryogenesis as G6PD-knockdown mouse cannot produce offspring and G6PD-deficient C. elegans with defective egg production and hatching.
G8 is a screening tool composed of @number@ questions that explore functional , cognitive and nutritional status.
GA and ventilation or Apgar were independent factors for raised peak Scr.
GABA also increased Klotho in the islet of Langerhans of normal mice , as well as the islets and kidneys of STZ-treated mice.
GABA and nAchR beta @number@ expressions were unchanged throughout in all the decades.
Gabapentin , levetiracetam , lamotrigine , topiramate , oxcarbazepine , lacosamide , and perampanel were defined as new-generation AEDs.
Gabapentin was shown to be opioid sparing , with lower doses for the intervention group versus the control group.
GABA transporter may contribute to improving S / N , provided that its reversal potential is close to the resting potential.
GACA's singular contribution to the mission of geriatric medicine must prompt vigorous efforts to restore it as a distinct funding opportunity.
GAD67 mRNA labeling was examined and quantified on X-ray films and emulsion radioautographs.
Gadd45a deficiency leads to DNA damage accumulation and impairment in apoptosis after exposure to IR , which increases the susceptibility of leukemogenesis.
Gadd45a has been involved in DNA damage response and in many malignancies , including leukemia.
GAD has clinical relevance for control of systolic BPV in elderly participants.
GAG composition was determined by disaccharide analysis.
GAG content in the cartilage explants was measured by using the dimethylmethylene blue method and Safranin O staining.
Gain- and loss-of-function experiments in mammalian cell lines and Xenopus embryos demonstrate that SDC4 and FN inhibit Wnt / β-catenin signaling.
GA incorporates measures of comorbidity , function , nutrition , social support , and other health-related domains to better describe physiologic age.
Gaining access to social participation was harmful for SRH for women ( OR @number@ 95%CI = @number@ @date@ ) .
Gaining further insight in spine plasticity regulation , its homeostatic nature and how to maintain spine health will be important future research topics in Neuroscience.
Gaining insights into genetic predisposition to age-related diseases and lifespan is a challenging task complicated by the elusive role of evolution in these phenotypes.
Gain-of-function genomic lesions of PI3K-AKT-mTOR pathway components are usually absent in CLL.
Gains and losses in DNA methylation are prominent features of mammalian cell types.
Gains in functional performance measures and retention effects , @number@ month later , were also observed.
Gains in lean mass were significantly greater in the ActRIIB.Fc group than in the placebo group ( P < @number@ ) .
Gains made in VO2max were maintained at @number@ months ( P < @number@ ) .
Gait analysis with walking as a single-task condition alone is often insufficient to reveal underlying gait disorders present during normal , everyday activities.
Gait and cognitive impairments in older adults can reflect the simultaneous existence of two syndromes that affect certain brain substrates and pathologies.
Gait , balance and cognition were assessed.
Gait balance is maintained by regulating the interactions between the center of mass ( CoM ) and base of support ( BoS ) .
Gait characteristics are \ "fit for purpose \ " when selected according to a clear rationale and in accordance with their clinimetric properties.
Gait decline is common among older adults and is a risk factor for adverse outcomes.
Gait disturbances in patients with chronic obstructive pulmonary disease ( COPD ) may lead to disability and falls.
Gait domains in WWT should be further studied to improve current fall risk assessments and to develop new interventions.
Gait during single and dual tasks was recorded in @number@ OSA patients at baseline and after @number@ weeks of CPAP therapy.
Gait has been presented as a relevant ( bio ) marker in ageing and pathological studies , with objective assessment achievable by inertial-based wearables.
Gait impairments are one of the biggest risk factors for falls.
Gait initiation involves a complex sequence of anticipatory postural adjustments ( APAs ) during the transition from steady state standing to forward locomotion.
Gait is a complex motor task , initiated and governed by different areas of the brain.
Gait outcomes worsened for the two PD participants who reported discomfort to cued walking and had high New Freezing of Gait scores.
Gait parameters and the number of correct responses were measured.
Gait parameters like step length , step width , gait line , maximum forces and gait variability were compared.
Gait patterns differ between healthy elders and those with Parkinson's disease ( PD ) .
Gait patterns in adults with cerebral palsy have , to our knowledge , never been assessed.
Gait performance exhibits patterns within the stride-to-stride variability that can be indexed using detrended fluctuation analysis ( DFA ) .
Gait performance was assessed by 4- and 400-m walking speed.
Gait performance was measured with a gait analysis system ( GAITRite Self-care and self-management programs are touted as a means to age successfully.
Gait slowing was calculated by bayesian slopes corrected for intercepts , with higher values indicating faster decline.
Gait speed and step length ( SL ) both significantly decreased with each age category at each of the first four steps.
Gait speed and stride length were normalized to the right leg length.
Gait speed and stride time variability were recorded at usual walking pace with the GAITRite system.
Gait speed , cognition , depressive symptoms , cardiovascular and pulmonary diseases , hypertension , stroke , and diabetes were measured at both time points.
Gait speed decreased in the narrow-based walking condition , with larger decrease in the elderly ( by @percent@ ) .
Gait speed decreased more in YA than OA during WT.
Gait speed did not vary significantly by menopausal status.
Gait speed , grip strength and appendicular skeletal muscle mass were assessed to determine sarcopenia.
Gait speed , hand grip strength , get-up-and-go and lean body mass ( LBM ) were evaluated before and after exercise training and detraining.
Gait speed increased after training.
Gait speed increased with GVS with normal vision but not BV.
Gait speed is a recommended geriatric assessment of physical performance , but may not be regularly examined in clinical settings.
Gait speed is a useful predictor of adverse outcomes , including incident mobility disability and mortality in older adults.
Gait speed is typically reduced when individuals simultaneously perform other tasks.
Gait speed is useful as a global characteristic of performance but may not capture the nature of underlying pathology.
Gait speed shows the highest effect size to discriminate between frailty subgroups , in particular during habitual walking ( d = @number@.76-6.17 ) .
Gait speed , step-time asymmetry , step and stride regularity related significantly ( p < 0.05 ) with several functional outcomes.
Gait speed , stride length , and stride time are calculated daily , and automatically assess for increasing fall risk.
Gait speeds were calculated from a fast-paced @number@ m walk test.
Gait speed was assessed using an instrumented walkway during single- and dual-task conditions.
Gait speed was measured as the time taken to complete a @number@ or 4m distance at normal walking speed.
Gait speed was measured at Visit @number@ ( \ "late-life \ " , aged ≥65 years , n = @number@ ) .
Gait speed was not considered , because of the recent hip fracture.
Gait speed was significantly or marginally associated with FEV1 and FVC in participants @number@ years or older , regardless of sex.
Gait speed was similar for either WMH or one of the OC ( p range : .07-.9 ) , except for BMI.
Gait stability was assessed using the margin of stability ( MoS ) .
Gait stability was evaluated using the short- and longer-term response to perturbation.
Gait symmetry and regularity were evaluated on the basis of autocorrelation functions of trunk accelerations of vertical and anteroposterior axes.
Gait symmetry was distinct from gait steadiness , and unaffected by cue symmetry or a diagnosis of PD , but associated with aging.
Gait variability also discriminates between different frailty status groups in particular during fast walking.
Gait variability may serve as a sensitive and clinically relevant parameter to quantify adjustments in walking and the changes with aging and neurological disease.
Gait velocity in both task conditions was associated with similar functional connectivity in sensorimotor , visual , vestibular , and left fronto-parietal cortical areas.
Gait velocity predicted persistence of mild parkinsonian signs , even after adjustments ( OR : @number@ @percent@ CI : @number@.94-0.98 ) .
Gait velocity was recorded under single-task and @number@ separate dual-task conditions using an electronic walkway.
Gait was assessed using the GAITRite electronic walkway system.
Gal-3 did not identify patients who responded to phosphodiesterase type @number@ ( PDE-5 ) inhibitors ( interaction p = @number@ ) .
Gal-3 was measured using ELISA and we used conditional logistic regression to compute adjusted odds ratios.
Galactocerebrosidase loss leads to the accumulation of psychosine and subsequent oligodendrocyte cell death , demyelination , macrophage recruitment , and astroglial activation and proliferation.
Galactorrhea and amenorrhea were less frequent in patients with NFPAH than in patients with PRS and PRDA.
Galangin is a flavonoid that exhibits anti-inflammatory and antioxidative potential.
Galanin ( GAL ) plays an integral role in consummatory behavior.
Galectin-3 ( Gal-3 ) , indicating cardiac fibrosis , is a documented biomarker of prognosis in HF.
Galectin @number@ modulates surface protein expression of a diverse set of glycoproteins including CD44 by regulating endocytosis of these proteins.
Galilean loupe , @number@.5× , @number@ mm ; and @number@
Gallbladder disease was defined as physician-diagnosed gallbladder disease.
Gallstones were the predominant etiological factor.
GAM analyses assessing the concurrence of thymoma and hyperplasia both showed reversed U-shapes , with peaks in the 50s and 20s-40s , respectively.
GAM analysis of the ocular form showed a U-shaped curve , with a dip in the 20s.
Game engagement and experience questionnaires were completed after each task , followed by a semistructured interview at the end of the testing session.
Games in a virtual reality ( VR ) environment stimulate the practice of communicative and cognitive skills and might also bring benefits to older adults.
Gamma-aminobutyric acid ( GABA ) is thought to play a major role in the neurobiology of depression.
Gamma irradiation accentuates these differences as the age of blood increases , indicating that at the biochemical level irradiation accelerates metabolic aging of stored RBCs.
Gamma power was increased during wake EEG in PSP ( p < @number@ ) .
Gamma-secretase catalyzes the final cleavage of APP to generate Abeta peptides.
Ganglion cell complex thickness was not associated with sex , intraocular pressure , or diabetes.
Ganglion cells number was lower in the older group , but plexus area was unchanged.
Gan mice spontaneously develop gastric tumors by activation of Wnt and prostaglandin E2 signaling pathways in gastric mucosa after @number@ weeks of age.
Ganoderma lucidum has now become recognized as an alternative adjuvant in the treatment of leukemia , carcinoma , hepatitis and diabetes.
Ganoderma lucidum is a well-known representative of mushrooms that have been used in traditional Chinese medicine for centuries.
Gaps between enamel and resin composite did not play a major role.
Gaps in practice have identified that care processes for these patients can be improved.
Gaps in this research are summarized with suggestions for future research.
Gas exchange was analysed breath-by-breath and muscle deoxygenation ( ∆ [ HHb ] ) was measured with NIRS.
Gastric biopsies were obtained from @number@ cancer-free subjects including @number@ chronic NSAID users and @number@ nonusers.
Gastric mucosal lesions were evaluated histologically.
Gastric mucosal visibility was normal in most patients either in F2 or F8 ( @percent@ vs. @percent@ ; P = @number@ ) .
Gastrin-stimulated gastric acid secretion was estimated with the endoscopic gastrin test.
Gastrointestinal adverse effects are one of the most often reported.
Gastrointestinal AEs were infrequent among patients treated with DSG and similar to incidence rates with vehicle in both age groups.
Gastrointestinal and urinary effects were the most common adverse events with both high doses of LMTM , and the most common causes for discontinuation.
Gastrointestinal behaviour was studied in vitro by looking at gastric coagulation and cumulative intestinal protein digestion over time.
Gastrointestinal disorders are a major cause of morbidity in the elderly population.
Gastrointestinal ( GI ) and bladder diagnoses were included up to @number@ months after diagnosis.
Gastrointestinal microbiota of the elderly is characterized by decreased butyrate production capacity , reflecting increased risk of degenerative diseases.
Gastrointestinal motility disorders often pose a debilitating problem , especially in elderly patients.
Gastrostomy tube ( GT ) feedings are commonly recommended to manage these co-morbidities.
Gates method underestimation of GFR was more pronounced in stage I patients treated with RAS inhibitors ( mean @number@ ml / min ) .
GATS is a nationally representative household survey.
GATS provided data on a representative sample of @number@ adult individuals @number@ male and @number@ female ever smokers.
Gaussian Graphical Models of metabolites found that @number@ lipid metabolites clustered into a single network.
Gaussian noise simultaneous maskers yield higher masked thresholds for pure tones than low-fluctuation noise simultaneous maskers for listeners with normal hearing.
GA was conducted before ( @percent@ ) , during ( @percent@ ) , or after ( @percent@ ) treatment.
Gay men more commonly indicated that the beginning of a relationship and HIV / AIDS related experiences were turning points.
GBA ( glucocerebrosidase ) is another accountable factor.
GBD @number@ did not report data for VTE as a cause of death and disability.
GBE effect on OXPHOS was even preserved in mitochondria after isolation from treated cells.
GBM cases were identified by searching the 1965-1998 databases using International Classification of Diseases ( ICD-9 ) codes.
GBM is rare in young adulthood , comprising @number@.1-3.6% of our patients.
GBMs contain rare cells that express stem cell markers and display ability to self-renew.
GCF and TBV did significantly differ in their associations across alcohol categories ( p interaction < @number@ ) .
GCF is a composite score derived from a battery of cognitive tests.
GCN analyses showed differences in topology and module composition between CT and PD networks for each anatomic region.
GCs in FI-3 oscillations were significantly higher in young subjects compared to older participants in the HUT state.
GCs were identified as corpuscular endings consisting of highly branched and coiled axons with many varicosities , which were immunoreactive for protein gene product @number@
GC treatment of HDF caused upregulation of 11β-HSD1 mRNA levels independent of donor age or site.
GDF11 impaired the recovery of skeletal muscle function in older rats after injury.
GDF11 inhibits the activity of the peroxisome proliferator-activated receptor γ ( PPAR-γ ) by promoting its SUMOylation.
GDF11 level is significantly decreased in the plasma and bone marrow of aging mice and mice with osteoporosis.
GDF15 levels were significantly elevated when comparing AUE with controls and were markedly elevated in patients with renal disease.
GDM-UC-MSCs also displayed significantly lower osteogenic and adipogenic differentiation potentials than N-UC-MSCs.
GEB increased procollagen type @number@ ( PC1 ) production and inhibited matrix metalloproteinase-1 ( MMP-1 ) production and elastase-1 activity in UVA-irradiated HDF.
GEE models were used to investigate changes in satisfaction within each of the five domains.
GEE negative binomial and logistic regression models were used.
Gefitinib treatment was discontinued owing to adverse events of liver dysfunction in @number@ patients , drug-induced pneumonitis in @number@ and diarrhea in @number@
Gelatinase inhibitors are thereby designated as chemotherapeutics or as mechanistic probe to figure out the unrecognized functions of MMP members.
Gelatin was injected into the subcutaneous tissues of @number@ heads.
Gelhorn HL , Roberts LJ , Khandelwal N , et al.
Gel loaded with ALA cubosomes provided a significantly lower release rate than the gel loaded with the un-encapsulated ALA.
Gelsolin ( GSN ) is a member of the actin-binding proteins , which regulate dynamic actin filament organization by severing and capping.
Gelsolin promoted solubilization of actin filaments and SSH1 in cell-free assays and in cultured cells.
Gemcitabine chemotherapy appears to be safe and the same treatment effect was seen even in older patients with pancreatic or biliary tract cancer.
GEN3VA is an open-source web-based system that is freely available at : @url@ .
Gender affected sacrum orientation in standing and in flexion as well as the L / P ratio.
Gender , age , and education essentially differentiate the preferences for base product ( carrier ) .
Gender , age , and education were covariates.
Gender , age and number of school years were explored as variables.
Gender , age and oily skin are risk factors , and sun protection and anti-aging cosmetic are protective factors with related to pore widening.
Gender , age , smoking status , and systolic blood pressure ( SBP ) were considered.
Gender also affected performance , with men having higher temporal frequency thresholds than women , independently of the number of targets.
Gender also affected the SBR , and there was a significant difference between males and females ( p = @number@ ) .
Gender also modified the effect of SNPs in SIRT3 , SIRT5 and AKT1 on lifespan.
Gender and Age affected most of the MCQ subscales but not the Level of Education ( LE ) .
Gender and age effects on the CRT method are unknown and may confound the results.
Gender- and age-related differences in the determinants of LTC needs were observed.
Gender and age were also significant variables in the model.
Gender and education only partially accounted for observed cohort trends.
Gender and functional health appear to be particularly important for physical activity participation , which may be useful in guiding future research.
Gender and genetic factors could possibly modulate this association.
Gender and heredity did not induce any significant difference in SOD activity between younger and older subgroups.
Gender did not moderate the association.
Gender did not significantly contribute to the onset of AA amyloidosis ( p = 0.569 ) .
Gender did not significantly moderate the associations between retirement transition and daily experiences.
Gender differences between leukocyte telomere lengths were observed for all cell subsets studied ; interestingly , this trend could already be detected at birth.
Gender differences , differences between persons from different age groups and persons reporting the environment as facilitating , hindering or neutral were calculated.
Gender differences exist in cardiovascular risk factors , co-morbidities , and also in therapy.
Gender differences in age-specific patterns of mental health were evident using the exact age of participants rather than the traditional decade groupings.
Gender differences in intra-day sedentary time were observed during morning hours with women accumulating less sedentary time overall and having more 1 + minute bouts.
Gender differences in J point height exist.
Gender differences in patients ' attitudes after disease diagnosis and their management of the disease have been identified.
Gender differences in performance times were analyzed between @number@ and @number@ years of age.
Gender differences in performance times were analyzed for the top @number@ male and female runners between @number@ and @number@ years of age.
Gender differences in running times decreased over the last three decades but remained relatively stable across the ages during the last decade.
Gender differences in sexual function were observed.
Gender differences in symptom profile , living conditions , coping style and response might affect the outcome of psychosocial interventions ( PSIs ) .
Gender differences in these associations were also observed.
Gender differences should be considered in planning and implementing programs.
Gender differences suggest that interventions to improve body satisfaction must be gender specific , particularly those relating to body functioning.
Gender differences were dominant on sexual desire and pleasure in old age.
Gender differences were observed in religious beliefs and religious coping , favoring women.
Gender difference was highest among patients @number@ years and older.
Gender difference was marginally significant ( p = @number@ log-rank test ) .
Gender differentiation in support transfers depends on the type of support examined and the living arrangements of parents and children.
Gender disparities in ADL disability were explained by chronic-disease risk factors and health conditions ( OR = @number@ @percent@ CI = @number@.94-2.25 ) .
Gender , educational level , and the number of chronic conditions were not associated with a change in SRTn over time.
Gender , education level , and economic status may have an important role in the etiology of MCI.
Gender effects are significant , with men demonstrating greater health benefit than women.
Gender effects suggest that the program effects on exercise are due mainly to improvements among women.
Gender effect was appeared more clearly in elderly than young participants.
Gender , genetic , LDL-C-related genotypes and aging-related changes should also be considered.
Gender had no significant effect on MEP magnitude and on submental activity during saliva swallowing.
Gender had no significant effect on the isoform frequencies.
Gender , height and age each had significant effects on certain values.
Gender imbalance should be taken into account when elaboration effective demographic , social and economic policies.
Gender is one such factor of this ' social location ' that must be acknowledged.
Gender modified this main effect.
Gender , occupation , resident area , experience with BLS training and knowledge about AED use were other independent factors.
Gender , race , and age were recorded and analyzed.
Gender , race / ethnicity , physical outcomes , physical function , and disease burden were not significantly different.
Gender-related differences were investigated across three age categories : 50-64 ; 65-79 and 80 + .
Gender-sensitive counseling and medical services for aging Iranian women can improve the quality of women's sexual lives.
Gender should be considered when planning fall prevention strategies.
Gender specific analyses revealed that this was true for women only.
Gender-specific approaches may be required to effectively control hypertension among older adults.
Gender-specific associations between fatigue and IADL-limitations and mobility were estimated by multivariable logistic and linear regression models.
Gender-specific differences in the perception of quality of life were reported for disabilities in specific IADL tasks.
Gender was registered as determinant only of MUNO probability.
Gene analysis revealed a homozygous V203I mutation in the PRNP.
Gene and protein expression changes related to apoptosis were investigated by semi-quantitative RT-PCR and western blotting , respectively.
Gene and protein expressions related to fibrosis , inflammation , and chondrogenesis were analyzed by quantitative reverse transcription-polymerase chain reaction and immunohistochemistry.
Gene and protein expression was measured by RTqPCR on RNA and by western blotting on protein extracts from muscle biopsies , respectively.
Gene and protein expression were analyzed by qRT-PCR and Western blot respectively.
Gene-based meta-analysis identified genome-wide significant associations ( ANGPT4 and FAM110A , q-value = @number@ GRM7-AS3 and LRFN5 , q-value = @number@ ) .
Gene-based testing revealed significant associations of FOXO3A variation with ADL ( P = @number@ ) and bone fracture ( P = @number@ ) .
Gene-centric CNV analysis of @number@ cases identified a list of @number@ genes most significantly targeted by tumor-associated alterations.
Gene deletion mutations of the @date@ transporter were shown to decrease overall lifespan of the worms and increase oxidative damage.
Gene-diet interactions for triglycerides were analyzed at baseline ( n = @number@ ) and after a 3-y intervention ( n = @number@ ) .
Gene-environment interactions are vital to consider in the search for specific genetic polymorphisms that affect brain integrity and connectivity.
Gene expression analyses were subsequently performed for identified genetic loci.
Gene expression and pathway analysis was performed on endothelial cell-enriched RNA and validated by immunohistochemistry.
Gene expression and release of cytokines analysed were significantly increased in ELF-EMF-exposed cells.
Gene expression changes , including the increased expression of MMP1 and MMP3 , were observed using Affymetrix GeneChip arrays and confirmed by qRT-PCR.
Gene expression changes in the brain affect cognition during normal and pathological aging.
Gene expression data of the @number@ genes that were detected in at least @number@ samples were analyzed.
Gene expression in skin samples was assessed by real-time polymerase chain reaction.
Gene expression in whole blood was measured using the Affymetrix Human Exon @number@ ST Array.
Gene expression is dependent on genetic and environmental factors.
Gene expression is known to be a stochastic phenomenon.
Gene expression is known to change in characteristic ways with age , and in particular DNA methylation changes in age-related ways.
Gene expression is known to change in characteristic ways with age , and in particular DNA methylation changes in age-related ways.
Gene expression of ActRIIB , myostatin , and TGF-β1 were higher in older adults compared to younger adults ( all p < @number@ ) .
Gene expression of IL6 and TNFα was not different between groups , while IL1-receptor and TNFα-receptor1 levels were lower with age.
Gene expression of key soluble factors was compared between CDCs derived from young and elderly patients.
Gene expression of receptor activator of nuclear factor-κB ligand ( RANKL ) was silenced by small interference RNA ( siRNA ) .
Gene expression of taste signaling molecules was analyzed in the tongue epithelium.
Gene expression patterns change dramatically in aging and age-related events.
Gene expression profiles were measured , analyzed , and entered into a newly generated database referred to as the GiSAO database.
Gene expression profiling revealed the JNK MAP kinase pathway as a driver of cell proliferation affected by cocaine in human astrocytes.
Gene expression showed that aging delayed differentiation of both bone and cartilage tissues during fracture healing.
Gene expression studies of ALS only rarely identify the same gene pathways as gene association studies.
Gene expression was analyzed using custom-designed low-density PCR arrays.
Gene identifications have revealed relevant pathways and mechanisms both in the bone-resorbing osteoclasts and bone-forming osteoblasts.
Gene methylation profiles were determined by methylated DNA immunoprecipitation-DNA microarray ( MeDIP-chip ) .
Gene mutations did not correlate with immunophenotype.
Gene mutations influence the outcome of age-related neuronal degeneration to cause early onset familial AD ( EO-FAD ) .
Gene mutations in several PD-related genes may affect up to @percent@ of the PD cases.
Gene mutations of RECQL2 , RECQL3 , and RECQL4 are associated with genetic disorders and induce early aging and carcinogenesis.
Gene ontology analysis revealed enrichment of smoking-related genes for activation of platelets and lymphocytes , immune response , and apoptosis.
Gene Ontology analysis revealed that @percent@ of the carbonylated proteins originated from organelles , @percent@ enrichment of which was demonstrated for the nucleus.
Gene ontology and KEGG pathway analysis were carried out using DAVID.
Gene ontology enrichment analysis indicates that robust disease-genes execute essential function in comparison with sensitive disease-genes.
Gene ontology ( GO ) analysis of the differentiated proteins showed that many were involved in inflammatory responses and implicated in fibrosis.
Gene polymorphisms of melatonin receptors and circadian oscillator proteins bear risks for several of the diseases mentioned.
Gene polymorphisms of the Annexin A gene may predict AVN in SCD.
General barriers were : competition with existing care and welfare organizations and scarce funding.
General cognitive ability , walking speed , lung function and grip strength were measured concurrently.
General cognitive functioning and , in particular , executive functioning showed significant overlap with social vulnerability after controlling for memory and age.
General cognitive function is substantially heritable across the human life course from adolescence to old age.
General cognitive function was assessed by the g-factor , which was derived from principal component analysis and captured @number@ % of all variance in cognition.
General cognitive status was assessed by ten questions via personal interviews.
General estimating equations will be used to determine differences between groups and over time.
General health of TKA recipients only improved relative to controls on @number@ of the @number@ study general health measures.
General health perception and a number of other self-reported disease-related and psychosocial factors improved , while exercise self-efficacy declined.
General health related quality of life ( HRQoL ) was measured with a 15D instrument.
General interest in health , food-neophobia and perceived self-efficacy seem also to contribute shaping the acceptance for functional dairy products.
General Internal Medicine research evolves in response to the needs of the patients to whom we provide care.
Generalised Estimating Equation ( GEE ) models , adjusted for age , waist circumference , physical activity , smoking and alcohol consumption were specified.
Generalised estimating equations were applied in multivariable regression models.
Generalised linear mixed model and multiple linear regression were used to analyse the data.
Generalizability of the pattern of findings was also investigated in @number@ samples from the general adult population.
Generalization to long times produces diffusion models of protein folding disorders in which epigenetic or life history factors determine the rate of onset of dysfunction.
Generalized additive models and Bland-Altman analyses supported the use of normalizing equations for transformation between cohort-specific and CDC values.
Generalized EEG seizures occurred more frequently than focal EEG seizures ( p < @number@ ) .
Generalized Estimating Equation ( GEE ) models were estimated for each country.
Generalized estimating equation ( GEE ) models were used to estimate the effect of a reduction in air pollution on respiratory symptoms and diseases.
Generalized estimating equation logistic regression was used to estimate associations.
Generalized estimating equation models were used for repeated analysis.
Generalized estimating equation models were used to examine the associations of CH with HRT and GDxVCC parameters , adjusted for disc area.
Generalized estimating equation models were used to test the time trend in ADL disability and its association with cardiometabolic diseases.
Generalized estimating equation models which controlled for demographics measures were employed.
Generalized estimating equations adjusted for individual- and neighborhood-level characteristics estimated mean differences and @percent@ confidence intervals ( CIs ) in mobility by social capital tertiles.
Generalized Estimating Equations analyses were performed to test the longitudinal effects of migraines on cognition.
Generalized estimating equations and generalized linear mixed-effects models were used to identify factors responsible for changes in physical functioning across different waves of data.
Generalized estimating equations ( GEEs ) were used to find associations between electroclinical features.
Generalized estimating equations time-lag models were used to examine the longitudinal associations between repeated measurements of hemoglobin and frailty.
Generalized estimating equations were used to account for repeated measures.
Generalized estimating equations were used to analyze differences between participants with and without OA , unadjusted as well as adjusted for confounders.
Generalized estimating equations were used to identify which of the need domains were perceived as most important by the participants.
Generalized linear mixed models were used to examine longitudinal trajectories of everyday functional limitations by diagnostic stability / progression.
Generalized linear mixed models were used to test predictors of mortality at subsequent 6-month intervals.
Generalized linear models assessed the association between GAD and depression with BPV over an 8year period.
Generalized linear models determined the mean adjusted difference ( MAD ) ( @percent@ confidence interval ) between groups during follow-up.
Generalized linear models estimated direct effects of emotional support on emotional well-being and indirect effects through fatalism and acceptance.
Generalized linear models examined effects of dementia severity , comorbidities , and their interactions on Medicare expenditures ( 1999-2010 ) .
Generalized linear models ( GLMs ) tolerate without bias only values missing completely at random and assume that all observations contribute equally.
Generalized linear models stratified by sex were used to compare the prevalence of reported fractures between survivors and siblings.
Generalized Linear Models were applied to estimate the impact of frailty and comorbidity on the healthcare costs.
Generalized linear models were used to estimate odds ratios for associations , accounting for clustering by facility.
Generalized linear models were used to estimate the effect of initiating medication modifications on subsequent 3-month medical use and costs.
Generalized ordered probit models were applied ; possible synergism was examined by testing for nonlinearity of the association.
Generalized tonic-clonic seizure ( GTCS ) is the commonest seizure type associated with sudden unexpected death in epilepsy ( SUDEP ) .
General linear ( for testosterone ) and a generalized negative-binomial model ( for depressive symptoms ) for repeated measures were used for analysis.
General linear model analysis was used as a statistical approach.
General linear models showed that choosing exercise predicted higher exercise self-regulation scores postprogram and @number@ months later.
General linear models were fit and multiple linear regression was performed.
General linear models were used to test for group differences.
General linear regression models evaluated the cross-sectional relations of GDS to HV or FDG in separate backward elimination models.
General linear regression was used to assess correlates of serum 25 ( OH ) D levels.
General longevity has continued to increase and , therefore , the age at which cochlear implants are placed has concomitantly increased.
General loss of mitochondrial biogenesis and function has repeatedly been linked to age-related perturbation of metabolic processes.
Generally , a wide variety of dance styles have been investigated in older adults , while a more limited subset has been evaluated in PD.
Generally , binary logistic regression models disclosed females with high SUA were twice likely to suffer from MS than males.
Generally , consequences due to LBP were more frequently reported than those due to NP or MBP.
Generally , cyclins and CKIs promote and inhibit CDK activation , respectively.
Generally , knowledge about aging was the strongest correlate of knowledge about sexuality.
Generally , more promising results were seen for combinations of multiple autoantibody markers.
Generally , older patients with diverticulitis may be regarded as too risky to undergo surgery.
Generally , subjects learn this task in a seated condition offering a stable postural platform.
Generally , the amount of produced sperm cells as well as their motility decreases with age , as testicular histological architecture deteriorates.
Generally , the full MNA confirmed the diagnosis for persons identified at risk by the MNA-SF , and planning was needed for nutritional interventions.
Generally , the validation of brain atrophy by P300 and WMS-III could lead to cost-effective methods utilizable in primary care medicine following further confirmation.
Generally , young people have a larger lip area and thickness than aged ones and men had larger lips than women.
General medicine and geriatric medicine groups had similar outcomes.
General neurotoxic Al effects were evaluated using a functional observational battery and a novel object recognition task.
General PA programs are common as health promotion initiatives.
General practices provided lists of individuals to be contacted and were asked to exclude those who had died or might die over the next month.
General practitioners are often the first point of contact for people with dementia , and their families.
General practitioners ( GPs ) will also need to adapt to the changing expectations of , and from , older patients across the upcoming generations.
General practitioners need to be aware of these risks and benefits in order to tailor the most appropriate treatment regimen to each individual patient.
General practitioners should be better trained regarding geriatric psychosocial issues and offer alternatives to prescribe psychotropic drugs such as cognitive behavior therapy for insomnia.
GENERAL PURPOSE : To provide an overview of the assessment and management of risk factors for falls in older adults.
GENERAL SIGNIFICANCE : Available studies on Pin1 suggest that cancer and AD may share biological pathways that are deregulated in different directions.
GENERAL SIGNIFICANCE : By administering resveratrol to healthy humans and utilizing primary immune cells we were able to detect TNF-α enhancing properties of the agent.
GENERAL SIGNIFICANCE : Estrogen-containing hormone therapy should not be initiated after age @number@ to prevent dementia or remediate cognitive aging.
GENERAL SIGNIFICANCE : Hydrogen is a novel antioxidant with great potential for actual medical applications.
GENERAL SIGNIFICANCE : Investigation of S-nitrosylation in the nervous system has elucidated new molecular and cellular mechanisms for neuronal development.
GENERAL SIGNIFICANCE : O-mannosyl glycan has a novel , unique structure that is important for the maintenance of brain and muscle functions.
GENERAL SIGNIFICANCE : We propose here a novel mechanism , by which jasmonate derivatives may elicit biological activities in mammals.
General supportive treatment is emphasised and is directed at maintaining homeostasis and the treatment of complications.
General WM capacity declines with age , but little is known of how cognitive aging affects WM function in deaf signers.
Generating a representative repertoire for each healthy cohort allowed agent-based modeling of the aging process.
Generating clinical data in these patients poses ethical and operational challenges , yielding results that may not be generalizable to the overall population.
Generating evidence regarding best practices that can prepare social work professionals for collaborative practice is essential.
Generating the investment in bridging aging and disability research across stakeholder group , including researchers and funders , is vital for these efforts.
Generational Dermatology is well suited to be a model for prevention as our patient's age and we can intervene at any decade.
Generational health improvements have mitigated the effects of population ageing , meaning that the population rate of sickness fell between @number@ and @number@
Generationally older C. neoformans cells are more resistant to hydrogen peroxide stress , macrophage intracellular killing , and antifungal agents.
Generation of linear estimates increased with age but decreased with numerical scale.
Generation shifts were examined graphically and by using logistic random effect models for men and women.
Generation shifts were studied between 10-year generations ( age range : 20-100 years ) .
Generativity has been argued to be an important indicator of successful aging.
Generativity is an adult's concern for and commitment to promoting the well-being of future generations.
Gene reconstruction revealed standard selenoprotein sequences except for GPx1 , which had an early stop codon , and SelP , which had low selenocysteine content.
Generic and recurring foundational pillars include integrated care models , team functioning and communication , leadership , change management and lean thinking.
Genes affect fiber integrity , but their effects vary with age , sex , SES and IQ.
Genes annotated to CpG sites showed enrichment in annotation clusters relating to phospho-metabolism and proteins with pleckstrin domains.
Genes associated with these pathways were found to have a crucial role in AD pathogenesis.
Genes dysregulated in human leukemias are enriched for canyon-associated genes.
Gene set analysis was performed using Genomica open-access software.
Gene set enrichment analysis identified enriched molecular signatures chosen from the Molecular Signatures Database.
Gene set enrichment analysis suggested that the BP-related global gene expression changes include genes involved in inflammatory response and apoptosis pathways.
Gene set enrichment showed significant associations for downregulated spontaneously hypertensive stroke-prone rat genes with WMH in humans.
Genes from the four modules were further projected onto predefined molecular interaction networks , revealing key drivers.
Genes have been recognized underlying memory disorders and longevity.
Gene silencing by small interfering RNA reduced the expression of AQP1 , and suppressed HG and HM-stimulated VCAM-1 expression.
Genes involved in lipid metabolism have dominated genetic studies of PPL TG response.
Genes may also play a significant role in acquired hearing loss due to aging , noise exposure , or ototoxic medications.
Gene-specific promoter methylation of several genes occurs in aging normal tissues and may predispose to tumorigenesis.
Genes regulating aging in C. elegans are evolutionarily conserved and their deregulation is often involved in the development of age-associated diseases in humans.
Genes related to the normal signature were enriched for aging-related gene ontology terms including metabolic processes , immune system processes , and cell proliferation.
Genes significantly regulated by age were compared with expression profiles in @number@ brain regions from @number@ postmortem brains aged @number@ to @number@ years.
Genes , the environment and stochastic factors such as lifestyle are major contributors to the universally shared phenomenon of ageing.
Gene subnetworks entailing molecular interactions between key drivers and BP-related genes were uncovered.
Genes underlying the signal at rs72838923 and mechanisms for the association warrant further investigation.
Genes up-regulated in aged bone are enriched for carbohydrate metabolism , TNFα and TGFβ superfamily components.
Genes which confer a relative longevity advantage may be regulated at the level of transcription or translation.
Gene targeting reveals that SMAP2-deficient male mice are healthy and survive to adulthood but are infertile and exhibit globozoospermia.
Gene therapy applications that target HSCs offer a great potential for the treatment of hematologic and immunologic diseases.
Gene therapy is a rapidly growing approach for the treatment of various diseases.
Gene therapy with nerve growth factor aimed at the NBM showed metabolic activation of various brain regions.
Genetic ablation of mPGES-1 resulted in markedly reduced tumor growth in PyMT mice.
Genetically determined senile wasting is thought to be associated with the necessity to renovate the population to ensure its adaptation and survival.
Genetically induced MT-I normalized copper dyshomeostasis in the spinal cord without influencing SOD1 enzymatic activity.
Genetically informative longitudinal studies on attachment relationship dimensions can help to illuminate the role of relationship-based risk factors in healthy aging.
Genetic alterations in this pathway via mutations and / or amplifications are often encountered in endometrial cancers.
Genetic analyses prioritized rs11263763 and four other SNPs in high-to-moderate linkage disequilibrium as the most likely causal SNPs.
Genetic analyses were based on structural equation models.
Genetic analyses were performed at the Center for Familial Breast and Ovarian Cancer in Cologne , Germany ; data analysis , @date@ through @date@ .
Genetic analysis did not report the presence of rapid or poor metabolizers.
Genetic analysis for APOE was conducted in @number@ patients and @number@ controls.
Genetic analysis revealed shorter abnormal expansion of CAG repeats ( less than @number@ ) .
Genetic analysis showed an increased burden of Parkinson disease-related risk factors and the disease-predisposing H1 / H1 microtubule-associated protein tau haplotype.
Genetic analysis with deletion and the RNAi-mediated reduction of subdued show that subdued is required for thermal nociception in nociceptors.
Genetic , anatomic and environmental factors influence the development of GO.
Genetic and acquired lipodystrophies are disorders of adipose tissue distribution.
Genetic and biochemical studies have identified transcription factors critical and specific for bone and cartilage development.
Genetic and early-life environmental factors may contribute to the midlife high adiposity-dementia association.
Genetic and environmental factors play an etiological role.
Genetic and environmental factors responsible for numerous neurodegenerative diseases vary between disorders , yet age remains a universal risk factor.
Genetic and epigenetic factors interact with environmental factors and contribute to the development of primary osteoarthritis.
Genetic and molecular evidence strongly suggest that dp53 is directly involved in the development of the cardiomyopathy induced by scox deficiency.
Genetic and non-genetic factors were tested for association with serum sclerostin.
Genetic and / or familial factors do not explain these associations.
Genetic and pharmacologic inhibition of PTP1B and PTEN abrogated O2∙ induced IGF-1 resistance and rescued the ageing skin phenotype.
Genetic and previous results support a model for the regulation of cadmium-inducible mtl-1 transcription based on the derepression of the constitutively active transcription factor ELT-2.
Genetic associations , however , rarely lead to direct identification of the relevant functional allele.
Genetic association studies in LOAD have successfully identified a large number of genetic variants involved in the development of the disease.
Genetic associations were tested using linear regression under additive model and results were combined in meta-analysis.
Genetic association was calculated using Fisher exact test.
Genetic-based classification also has limitations as mutations in the same gene are sometimes associated with different clinically based diagnoses.
Genetic causes of hydrocephalus are poorly understood in humans , but animal models suggest a broad genetic program underlying the regulation of CSF balance.
Genetic data were obtained from the Alzheimer's Disease Genetics Consortium , linked to autopsy-derived neuropathological outcomes from the National Alzheimer's Coordinating Center.
Genetic defects in these mechanisms that have clear harmful effects in the exposed skin are found in several human syndromes.
Genetic deficiency , and the pharmacologic ablation of B-lymphocytes using an anti-CD20 antibody , prevents the appearance of delayed cognitive deficits.
Genetic deletion of miR-1000 led to elevated apoptosis in the brain as a result of glutamatergic excitotoxicity.
Genetic determinants of ucMGP were also explored.
Genetic effects and nonshared environmental effects are primary sources of stability of late life depressive symptoms without evidence of underlying rGE processes.
Genetic engineering of HK represents a promising technique to improve engraftment and survival of transplants.
Genetic , environmental and stochastic factors have been shown to influence telomere attrition.
Genetic , epigenetic , hormonal and environmental factors can regulate telomerase function.
Genetic epistasis analysis reveals that hsp-16 is essential for the lifespan extension by bmk-1.
Genetic factors are also important , with genes important in lung development and early wheezing also being implicated in COPD.
Genetic factors could explain @percent@ , @percent@ and @percent@ of the variation in Hcy concentration among children , male adults and female adults , respectively.
Genetic factors have been estimated to account for about @percent@ of the variation in an adult's life span.
Genetic factors impact both the risk for hypertension and the therapeutic effect of antihypertensive drugs.
Genetic factors influencing prognosis should be taken into account to include homogeneous groups in future clinical trials and to monitor efficacy of future interventions.
Genetic factors may account , in part , for GWG / ΔBMI association.
Genetic factors play an important role in the Alzheimer's disease ( AD ) development and memory impairment is a cardinal clinical feature of AD.
Genetic factors primarily contribute to stability , while change reflects the influence of nonshared environmental influences.
Genetic inactivation of DLP1 completely blocks MPP ( + ) -induced mitochondrial fragmentation.
Genetic influences were greater in adolescence versus adulthood , and greater in males than in females.
Genetic influences were higher in men and on the left hemisphere compared with the right.
Genetic inhibition of AEL function results in decreased Aβ1-42 accumulation.
Genetic inhibition of PARP activity attenuated the deleterious effects seen on depleted muscles in mouse models of oncologic cachexia.
Geneticists have had for many years a protocol to identify Mendelian disease.
Genetic loci with multiple trait associations have also provided novel biological insights.
Genetic manipulation of sirtuin @number@ levels in vitro and in vivo modulates the levels of α-synuclein acetylation , its aggregation , and autophagy.
Genetic modeling was performed with MPlus statistical software.
Genetic mutations in APP , PSEN1 or PSEN2 can lead to early onset of familial AD ( FAD ) .
Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder ( BD ) .
Genetic or pharmacologic inhibition of RON kinase blocked cancer-mediated bone destruction and osteoporosis in several mouse models.
Genetic polymorphisms independently appeared to explain @percent@ and @percent@ of the variation in levels of vitamin D-binding protein and total 25-hydroxyvitamin D , respectively.
Genetic polymorphisms may affect human male fertility.
Genetic polymorphisms of ethanol metabolizing enzymes and cytochrome p450 ( CYP ) 2E1 activation may change the severity of ASH and NASH.
Genetic predisposition , such as point mutations and copy number variants of the SNCA gene locus can cause very similar PD-like neurodegeneration.
Genetic predisposition to advanced biological ageing may be one factor driving previously reported associations ( or lack of associations ) between shorter TL and MDD.
Genetic programs involved in T-cell signaling and DNA repair are of high interest in the search for underlying molecular defects.
Genetic reduction of p16 ( INK4a ) levels reverses the pathology of Bmi1-deficient hearts.
Genetic research aims to understand the underlying mechanisms of ALS and identify potential therapeutic targets.
Genetic risk factors for MDD were related to AUD , but their association with AUD did not increase over time.
Genetic risk score , older age , and female sex independently correlated with each outcome.
Genetic risk scores were computed based on published genome-wide association study discoveries for obesity.
Genetics and epigenetics are reported to play large roles in accelerating and / or delaying the onset of age-related diseases.
Genetics and lifestyle independently determine dementia risk , but the interaction is unclear.
Genetic screening did not reveal any variation in the TGFBR2 gene in the patients.
Genetic screening of healthy controls and in silico analysis provide support for the potential pathogenicity of this variant.
Genetics has proven to be a powerful approach in neurodegenerative diseases research , resulting in the identification of numerous causal and risk variants.
Genetic studies have also pointed out the close relationships between ageing , inflammatory processes , lipodystrophy , and IR.
Genetic studies indicate that protein homeostasis is a major contributor to metazoan longevity.
Genetic studies later revealed that endogenous RA promotes forelimb initiation by repressing fibroblast growth factor @number@ ( Fgf8 ) .
Genetic studies of AMD patients confirmed that genetic variants affecting the alternative complement pathway have a major influence on AMD risk.
Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years.
Genetic studies of complex traits have mainly identified associations with noncoding variants.
Genetic studies of these two diseases share common features and face similar problems , although their current statuses are very different.
Genetic susceptibility is likely to play a role in response to air pollution.
Genetic testing of the proband revealed an N135Y missense mutation in PSEN1.
GENETIC TOXICOLOGY : beta-myrcene did not show evidence of genotoxicity in assays conducted by the NTP.
Genetic toxicology studies were conducted in Salmonella typhimurium , Escherichia coli , and mouse peripheral blood erythrocytes.
Genetic variants at PTK2B-CLU locus pose as high-risk factors for many age-related disorders.
Genetic variants in SREBF1 , PHOSPHO1 , ABCG1 and CPT1A were also associated with lipid profile.
Genetic variants in the growth pathway gene showed an association with prostate cancer risk.
Genetic variants in the IGF2 / H19 locus were associated with IGF2DMR DNA methylation ( P-value < 0.05 ) , but not with H19 methylation.
Genetic variants of whole mitochondrial DNA ( mtDNA ) that predispose to exceptional longevity need to be systematically identified and appraised.
Genetic variation alone may not account for common chronic disease susceptibility.
Genetic variation in circadian rhythm genes provides a tool to investigate such associations.
Genetic variation in FOXO3A has previously been associated with human longevity.
Genetic variation in klotho has been reported to be a risk factor for coronary artery disease and ischemic stroke.
Genetic variation in this pathway may also affect human longevity.
Genetic variation is associated with differences in the function of the brain as well as its susceptibility to disease.
Genetic variation may modulate corresponding protein levels and point to the role of these variants in disease pathophysiology.
Genetic variations in the estrogen receptor ( ER ) are associated with cardiovascular disease.
Genital regions with Isl1 expression included the peri-cloacal mesenchyme and the urorectal septum.
Genital warts are common and associated with HPV types @number@ and @number@
Genitourinary pathologists ordered significantly fewer IHC tests per case and per biopsy than non-GU pathologists.
Genome and epigenome editing technologies can be applied to many aspects of aging research and offer the potential to develop novel therapeutics against age-related diseases.
Genome instability has been implicated in neurodegenerative processes in aging and disease.
Genome instability has long been implicated as a salient causal factor in aging and age-related diseases such as cancer and neurodegeneration.
Genome instability represents a primary hallmark of aging and cancer.
Genome maintenance ( GM ) is an essential defense system against aging and cancer , as both are characterized by increased genome instability.
Genome maintenance is beneficial early in life by swiftly eliminating DNA damage or damaged cells , facilitating rapid cell proliferation.
Genomes are inherently unstable because of the need for DNA sequence variation as a substrate for evolution through natural selection.
Genomes are transmitted faithfully from dividing cells to their offspring.
Genome sequencing efforts have identified virtually all of the important mutations in adult myeloid malignancies.
Genome-wide analyses of common single-nucleotide polymorphisms indicate that they jointly tag between a quarter and a half of the variance in intelligence.
Genome-wide association analysis was used to investigate gene expression and , separately , DNA methylation for signals associated with the R2 measure.
Genome wide association studies and candidate gene screens have identified members of the complement pathway as contributing to the risk of AMD.
Genome-wide association studies are identifying novel Alzheimer's disease ( AD ) risk factors.
Genome-wide association studies ( GWAS ) have been shown to be a powerful approach to identify risk loci for neurodegenerative diseases.
Genome-wide association studies ( GWAS ) have been successful in uncovering genetic determinants of age at menarche and age at natural menopause.
Genome-wide association studies ( GWAS ) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations.
Genome-wide association studies ( GWAS ) have identified numerous loci associated with blood pressure ( BP ) .
Genome-wide association studies ( GWAS ) have identified over @number@ single nucleotide polymorphisms ( SNPs ) associated with prostate cancer.
Genome-wide association studies ( GWAS ) have identified several risk variants for late-onset Alzheimer's disease ( LOAD ) .
Genome-wide association studies ( GWAS ) have implicated a series of single nucleotide polymorphisms ( SNPs ) in Alzheimer's disease ( AD ) risk.
Genome-wide association studies ( GWAS ) have revealed @number@ single nucleotide polymorphisms ( SNPs ) associated with high-density lipoprotein cholesterol ( HDL ) blood levels.
Genome-wide association studies ( GWAS ) have shown its revolutionary power in seeking the influenced loci on complex diseases genetically.
Genome-wide association studies ( GWAS ) have successfully identified a number of common single-nucleotide polymorphisms ( SNPs ) associated with CRC risk.
Genome-wide association studies ( GWAS ) have uncovered numerous genetic variants ( SNPs ) that are associated with blood pressure ( BP ) .
Genome-wide association studies ( GWAS ) play a key role in discovering genetic variations that may contribute towards disease vulnerability.
Genome-wide association studies ( GWASs ) have identified loci for erythrocyte traits in primarily European ancestry populations.
Genome-wide association studies ( GWASs ) have identified many genetic variants underlying complex traits.
Genome-wide association studies ( GWASs ) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry.
Genome-wide association studies have identified > 50 common variants associated with kidney function , but these variants do not fully explain the variation in eGFR.
Genome-wide association studies have identified multiple additional risk factors , but to date none have yielded an effective alternate therapeutic target.
Genome-wide association studies have identified novel risk variants for Alzheimer's disease ( AD ) .
Genome-wide association studies have identified @number@ risk variants for prostate cancer , which can explain approximately @percent@ of the familial risk of the disease.
Genome-wide association studies have revealed numerous risk loci associated with diverse diseases.
Genome-wide association studies identified numerous disease risk loci.
Genome-wide association study of ADM expression and MR-pro-ADM levels both identified a single locus encompassing the ADM gene.
Genome-wide complex trait analysis estimates that common genetic variants account for about @percent@ of the variation contributing to liability for AD.
Genome-wide complex trait analysis revealed that known risk loci explain disease risk in @percent@ of Greek PD patients.
Genome-wide data were obtained using the Affymetrix @number@ and Illumina HumanOmni chips.
Genome-wide epigenetic modification dynamics , including DNA methylation and chromatin modification , are involved in biological processes such as development , aging , and disease.
Genome-wide expression analyses revealed that several genes encoding components of SUMOylation pathway and ubiquitin-proteasome system were upregulated in SUMO-overexpressing nematodes.
Genome-wide expression analysis of fat-3 mutants revealed hundreds of changes.
Genome-wide gene expression analysis by RNA sequencing indicated that RGFP963 and RGFP966 induce largely distinct transcriptional profiles in the dorsal hippocampus of mature mice.
Genome-wide gene expressions in bone biopsies from patients with postmenopausal osteoporosis and healthy controls were profiled , to identify osteoporosis candidate genes.
Genome-wide interaction analyses were performed separately in each study for about @number@ million single nucleotide polymorphisms ( SNPs ) across the @number@ autosomal chromosomes.
Genome-wide linkage analysis revealed that EEM was linked to the 6q24 region ( maximum logarithm of odds score , @number@ ) .
Genome-wide mapping reveals @number@ NADs in proliferating cells , which cover about @percent@ of the annotated human genome.
Genome-wide scan in the Atherosclerosis Risk in Communities ( ARIC ) Study ( N = @number@ ) was used to pre-select promising loci.
Genome-wide screening of androgen target genes provides useful information to understand a global view of AR-mediated gene network in PCa.
Genome-wide significant association was identified at two loci.
Genome-wide SNP genotyping of Gordon Setters identified a @number@ MB region with an identical haplotype to affected Old English Sheepdogs.
Genome-wide studies are underway to systematically expand methylation classifier panels and find the best combinations of biomarkers.
Genome-wide studies of aging have identified subsets of genes that show age-related changes in expression.
Genome-wide transcriptional profiling of TSCs following Lsd1 inhibition shows gene set enrichment of aging and metabolic pathways.
Genomic and proteomic expression of various junctional proteins was determined using Affymetrix and common Western blotting techniques.
Genomic convergence is a method that combines multiple types of functional genomic information such as transcriptional profiling , expression quantitative trait mapping and gene association.
Genomic data are available including genome-wide genetic data of @number@ @number@ participants.
Genomic DNA is damaged at an extremely high frequency by both endogenous and environmental factors.
Genomic DNA was extracted and subjects were genotyped for the 45-bp I / D polymorphism in the @number@'-untranslated region of UCP2.
Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction.
Genomic DNA was extracted from peripheral blood leukocytes.
Genomic DNA was extracted from peripheral blood leukocytes.
Genomic imprinting is the allele-specific expression of a gene based on parental origin.
Genomic instability , deregulated nutrient sensing and mitochondrial dysfunction are established hallmark of aging.
Genomic instability due to telomere shortening plays an important role in carcinoma development.
Genomic instability is recognized as one of the primary mechanisms that lead to organismal aging.
Genomic profiling completed by NGS allowed us to classify pRCC2 in several groups and to identify novel mutations.
Genomics and genetics have invaded all aspects of biology and medicine , opening uncharted territory for scientific exploration.
Genomic sequencing provides a powerful diagnostic modality for patients who manifest symptoms of monogenic disease and an opportunity to detect health conditions before their development.
Genotoxicity of the experimentally generated AGEs was confirmed by comet-assay.
Genotoxic perturbation holds a central place in cancer formation and aging , but also is key to cancer therapy by irradiation or chemotherapeutic drugs.
Genotype analyses , including the APOE polymorphism , were made in blinded fashion.
Genotype-endophenotype associations were determined by linear regression analyses.
Genotype imputation is now routinely applied in genome-wide association studies ( GWAS ) and meta-analyses.
Genotype-phenotype analyses may help to target pathways that are important in AMD.
Genotype-phenotype correlations and long-term follow-up description in BM remain scarce.
Genotype-phenotype relationships in infants and children must take into account the role that ontogeny plays in producing variability in both pharmacokinetics and pharmacodynamics.
Genotypes A ( @number@ % ) , F ( @number@ % ) and D ( @number@ % ) were identified.
Genotypes for MnSOD Ala-9-Val gene polymorphism were identified by using polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFPL ) .
Genotypes for @number@ variants were measured or imputed from HapMap.
Genotypes were analysed by commercially available microarray assays and results were confirmed by real-time polymerase chain reaction analysis.
Genotypes were validated using direct sequencing in a smaller sample.
Genotypic and clinical factors were investigated for associations with PIPN.
Genotypic frequencies were @percent@ for TT and @percent@ for TC.
Genotypic imputation was performed using reference @number@ Genomes Project data.
Genotypic information about asthma risk was independent of and additive to information derived from cohort members ' family histories of asthma.
Genotyping arrays are a cost effective approach when typing previously-identified genetic polymorphisms in large numbers of samples.
Genotyping , however , was not obtained until Wave @number@
Genotyping of APOE was determined by multiplex amplification refractory mutation system polymerase chain reaction.
Genotyping of six additional breeds of dogs affected with hereditary ataxia identified the same polymorphism in affected Gordon Setters that segregated perfectly with phenotype.
Genotyping of the ER-α polymorphism was performed using a polymerase chain reaction and restriction enzymes ( PCR-RFLP ) .
Genotyping of the MTHFR C677T polymorphism was performed by TaqMan probe technique.
Genotyping revealed genetic diversity within the German ARAF isolates and no clustering with resistant isolates from the Netherlands , India and France.
Genotypings of klotho in terms of G395A in the promoter region , C1818T in exon @number@ and KL-VS was performed.
Genotyping the mice for the rd8 ( del C at nt3481 in Crb1 ) and Ctrp5 S163R mutations was performed with allelic PCR or sequencing.
Genotyping was carried out on Affymetrix or Illumina platforms followed by imputation of genotypes in most studies.
Genotyping was done by polymerase chain reaction and restriction fragment length polymorphism.
Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism.
Genotyping was performed in @number@ long-lived individuals ( LLIs ) and @number@ ethnically matched control subjects.
Genotyping was performed using polymerase chain reaction-based restriction fragment length polymorphism ( PCR-RFLP ) method.
Gently inhibiting the mitotic Cdk1 or add-back of p21 rescues segregation defect in HCT116 p21- / - cells.
Geocoded data were used to calculate proximity of a child's residence to food and physical activity outlets.
Geographical information on the study participants was also obtained.
Geographical micro-heterogeneity of survival predictors emerged , such as functional and physical status being more important in Southern than in Central and Northern Italy.
Geographic information systems ( GIS ) analyses were performed using ArcGIS software through its module Spatial Autocorrelation.
Geographic Information Systems were used to objectively measure BE attributes.
Geometric average diffusion measures can be useful to minimize the intrinsic local magnetic susceptibility variations in brain tissue.
Geometric features associated with presence of ACD were determined by using the nondiseased contralateral carotid artery as an intrinsic control.
Geometric parameters , such as Lumbar Lordosis Angle , Index of Lumbar Lordosis , Whitmann-Ferguson Angle and Anterior Pelvic Tilt , were also measured.
Geometry can be classified into LV hypertrophy ( LVH ) , concentric remodelling ( CR ) or normal geometry ( NG ) .
George's social antecedent model of psychopathology was used to examine @number@ predictor variables of auditory hallucinations.
GEPCI quantitative metrics characterizing tissue cellular integrity in the hippocampus demonstrated much stronger correlations with psychometric tests than the hippocampal atrophy.
Gephyrin accumulations in AD overlapped with β-amyloid plaques and , more rarely , neurofibrillary tangles.
Gephyrin is a postsynaptic scaffolding protein , essential for the clustering of glycine and γ-aminobutyric acid type-A receptors ( GABAARs ) at inhibitory synapses.
Geriatr Gerontol Int 2017 : @number@ ( Suppl.
Geriatr Gerontol Int 2017 : @number@ ( Suppl.
Geriatr Gerontol Int 2017 : @number@ ( Suppl.
Geriatr Gerontol Int 2017 : @number@ ( Suppl.
Geriatr Gerontol Int 2017 : @number@ ( Suppl.
Geriatr Gerontol Int 2017 : @number@ ( Suppl.
Geriatr Gerontol Int 2017 : @number@ ( Suppl.
Geriatr Gerontol Int @number@ 15 : 1242-1248.
Geriatr Gerontol Int @number@ 16 : 810-820.
Geriatr Gerontol Int @number@ 16 : 856-864.
Geriatr Gerontol Int @number@ 16 : 873-879.
Geriatr Gerontol Int @number@ 16 : 911-919.
Geriatr Gerontol Int @number@ 16 : 934-941.
Geriatr Gerontol Int @number@ @number@ ( Suppl.
Geriatr Gerontol Int @number@ @number@ ( Suppl.
Geriatric anaesthesia is emerging as a new subspecialty.
Geriatric assessment and co-morbidities can affect the prognosis modifying surveillance , life expectancy and compliance to therapies.
Geriatric assessment ( GA ) used in the field of geriatric medicine is reported to be useful for risk assessment of chemotherapy.
Geriatric assessment helps to identify frail patients according to their functional and cognitive status.
Geriatric assessment is an increasingly important area of outpatient medicine , given the unprecedented aging of the US population.
Geriatric care principles best embody this approach.
Geriatric chronic hepatitis C ( CHC ) patients would be viewed as a special population and have an urgent need for viral eradication.
Geriatric conditions were assessed and the burden scored as a composite of geriatric conditions present in an individual ( total score = @number@ ) .
Geriatric depression exacerbates the symptoms of comorbid disorders.
Geriatric depression is a general definition of a multidimensional disorder with multiple risk factors.
Geriatric depression is discussed taking into consideration some data from translational research.
Geriatric depression occurs in the context of illnesses in which inflammatory processes are part of the pathogenesis.
Geriatric depression often occurs in persons exposed to chronic stress , a state precipitating geriatric depression and triggering proinflammatory responses.
Geriatric Depression Scale scores , Activities of Daily Living scores , and QOL scores significantly improved after treatment.
Geriatric dermatology in India is gaining steady momentum , because the aging population is dramatically increasing.
Geriatric diabetes care guidelines have refocused from risk factor control to geriatric syndromes.
Geriatric dogs consuming all three foods increased ( P < 0.001 ) GFR over time ; group averages ranged from @date@ @percent@.
Geriatric dogs were compared before and after the feeding trial with mature adult dogs.
Geriatric fall assessment was conducted by self-report questionnaires.
Geriatric health care has become a major issue worldwide.
Geriatric health is an ignored and under-explored area worldwide.
Geriatric horses defined as horses above the age of @number@ exhibit a decline in body condition , muscle tone and general well-being.
Geriatricians also recorded recommendations for referrals and variations for medication management and judgment regarding prognosis at discharge and after @number@ months.
Geriatricians and hospitalists differ in their approach to older adults.
Geriatricians and other primary care providers should be encouraged to refer patients with chronic conditions to such self-management programs.
Geriatricians have long recognized a syndrome of multiple comorbid conditions , immobility , weakness , and poor tolerance of physiologic stressors in older adults.
Geriatricians reported more routine medication reviews , functional and cognitive assessments , and fall evaluations.
Geriatric oncology is a rapidly expanding domain because of the deep epidemiological changes of the last decades related to the ageing of the population.
Geriatric patients are at an increased risk for renal dysfunction from many causes.
Geriatric patients are not defined by their age but by their general profile.
Geriatric patients often experience insomnia because of physiological and neurological changes that occur during the aging process.
Geriatric patients presenting for psychiatric treatment may also be misdiagnosed or under-diagnosed as a result of these visual problems.
Geriatric pharmacotherapy represents one of the biggest achievements of modern medical interventions.
Geriatrics is a complex patient population and basic nursing care is essential to prevent unnecessary complications if our health care system is to survive.
Geriatrics students also reported more positive attitudes toward older adults.
Geriatrics students performed just as well on the NBME exam as their internal medicine colleagues , but reported greater comfort with elder care.
Geriatric syndrome and higher prevalence of co-morbidities amongst older inmates result in heightened vulnerability in prison environments.
Geriatric syndromes , such as underweight , functional disability , and depressive condition , contributed to the risk of mortality.
Geriatric years are characterized by increased susceptibility to infections and a reduced antibody response to vaccination as a result of changes in the immune system.
German and USA survival rates were compared utilizing the Surveillance , Epidemiology and End Results @number@ database.
German Clinical Trials Register : DRKS00005450.
German women had higher CD concentrations in the neck skin than Japanese women.
Germ cell and embryonic stem cells are inextricably linked in many aspects.
Germ cells function as a kind of \ "transgenerational stem cells , \ " transmitting genetic information from one generation to the next.
Germ-free mice on a GE diet showed differences in microbial composition as compared to mice on control diet.
Germline mutations in BRAF cause CFC syndrome , which is characterized by heart defects , distinctive facial features and ectodermal abnormalities.
Geroconversion is driven by growth-promoting , mitogen- / nutrient-sensing pathways such as mTOR.
Geroconversion leads to hyper-secretory , hypertrophic and pro-inflammatory cellular phenotypes , hyperfunctions and malfunctions.
Geroconversion was associated with active mTOR and S6 kinase ( S6K ) .
Geroconvesrion is a form of growth , a futile growth during cell cycle arrest.
Gerontechnologies in vulnerable and frail elderly people can compensate impaired orientation and memory , widen the possibility to communicate , exchange information , and move.
Gerontological nurses , as members of the global community , are encouraged to become partners in promoting active and healthy aging.
Gerontology and geriatrics are interdisciplinary professions.
Gerontome is available free at @url@
Geroprotective action of vilon and epitalon probably realizes in suppression of these genes.
Geroscience is an interdisciplinary field that aims to understand the relationship between the biology of aging and the biology of age-related diseases.
Gestational age acceleration prediction from DNA methylation array data may provide insight into the molecular mechanisms of pregnancy disorders.
Gestational age and timing of growth were not associated with future vertebral CSA.
Gestational diabetes mellitus ( GDM ) is the most frequent metabolic disorder in pregnancy.
Gestures are the first forms of conventional communication that young children develop in order to intentionally convey a specific message.
Getis-Ord G , Gravity modeling , and Pearson's
Getting at least @number@ hours of sleep at night may either protect telomeres from damage or restore them on a nightly basis.
Getting up @number@ or more times at night to urinate was coded as nocturia.
GFAPδ-immunopositive astrocytes were observed in subgranular zone , hilus , and
GFAPδ-positive cells also stained for GFAPα.
GFR and extracellular fluid volume ( ECV ) were measured using Cr-51-EDTA.
GFR was estimated and defined as decreased when < 60 mL / min / 1.73m2.
GFR was estimated using the modification of diet in renal disease equation.
GFR was measured using iohexol clearance at baseline and follow-up.
GG combined better redispersion with minimal changes in viscosity on storage compared to Na-CMC and HPMC as suspending agent.
G-GR was well tolerated , and the incidence of the most common AEs did not appear to be age related.
GGsTop has been widely used in academic and medicinal research , and also as an active ingredient ( Nahlsgen ) in commercial anti-aging cosmetics.
GGT activity was measured using a fluorescent probe , γ-glutamyl hydroxymethyl rhodamine green ( gGlu-HMRG ) .
GGT correlated with GPx , and with age , across all subjects ( p < @number@ ) .
Ghana has a shorter life expectancy than middle- and high-income countries and its current age of retirement is @number@ years.
Ghana has introduced a National Health Insurance Scheme ( NHIS ) .
GH and IGF-1 affect the genesis of neurons , astrocytes , endothelial cells and oligodendrocytes.
GH and melatonin may be potential agents for counteracting oxidative stress , apoptosis and inflammation in the aging heart.
GHB efficiently and dose-dependently rescued native and genetically modified cells from H2O2-induced death.
GH can counteract the deleterious immunosuppressive effects of stress-induced steroids.
GH had a significant effect on several bone metabolism biomarkers.
GH / IGF1 is likely to play an important role in the regulation of tendon and muscle collagen.
GH / IGF-I axis is involved in the regulation of brain growth , development , and metabolism.
GH or melatonin treatment prevented the age-dependent cardiac alterations observed in the senescence-accelerated prone group.
Ghrelin and adiponectin increased @percent@ and @percent@ , respectively , in exercise group participants following exercise training.
Ghrelin and cortisol responses were correlated , r ( @number@ ) = 0.558 , p = .016.
Ghrelin improves the survival prognosis of myocardial infarction by reducing sympathetic nerve activity.
Ghrelin is famously known as the ' hunger hormone'.
Ghrelin is the strongest GH secretagogue known to date , but the role of endogenous ghrelin in the regulation of circulating GH levels remains controversial.
Ghrelin prevents muscle atrophy by inducing muscle differentiation and fusion.
Ghrelin regulates bone formation and metabolism by modulating proliferation and differentiation of osteoblasts.
Ghrelin regulates homeostatic food intake , hedonic eating , and is a mediator in the stress response.
Ghrelin's hallmark functions are its stimulatory effects on growth hormone release , food intake and fat deposition.
Ghrelin signalling decreases thermogenesis to regulate energy expenditure.
Ghrelin , the natural ligand for the growth hormone ( GH ) -secretagogue receptor ( GHS-R ) , is produced in the stomach.
Ghrelin was measured in an in-house , two-site sandwich ELISA specific for full-length acyl-ghrelin.
GH replacement increases IGF-I levels and reduces CRP and large-artery stiffness.
GHSR null mice exhibited significantly reduced taste responsivity to sour ( citric acid ) and salty ( sodium chloride ) tastants.
GH was measured in a sensitive assay ( Immulite @number@ ) , and GH peaks were determined by deconvolution analysis.
GI and GL for each patient's diet were calculated from a previously validated , semi-quantitative , 137-item food frequency questionnaire.
GI and GL were not associated with risk of adiposity-related cancers or any of the site-specific cancers.
Giant somatosensory evoked potentials were observed in @number@ of the @number@ patients.
GI diseases refer to diseases of the esophagus , stomach , small intestine , colon , and rectum.
GI disorders ( @percent@ ) and seizure disorders ( @percent@ ) were common , and @percent@ of the sample had a BMI > 30.
GILZ activates caspase-8 , promoting GILZ sumoylation and its protection from proteasomal degradation.
Ginger extract is used as an analeptic in herbal medicine and has been reported to exert antioxidant effects.
Gingival fibroblasts were isolated from six patients ( 3Y ; and 3E ) and seeded in complete culture medium ( DMEM ) .
Gingival recession is the main causal factor of root caries and dentine hypersensitivity.
Gingival wound healing comprises a series of sequential responses that allow the closure of breaches in the masticatory mucosa.
Gingival wound healing is one of the impaired processes found in old rats.
Ginkgo aglucone flavone is a kind of effective natural antioxidant.
Ginkgo biloba extract ( GBE ) could be an effective mean to improve gait stability.
Ginseng , an oriental gift to the world of healthcare and preventive medicine , is among the top ten medicinal herbs globally.
Ginseng has shown potential antidepressant effects in some animal studies and in patients with stress-related somatic symptoms.
Ginseng , the root of Panax ginseng , has been used in traditional Chinese medicine as a tonic herb that provides many beneficial effects.
Ginsenoside F1 suppresses the SASP from astrocytes induced by d-galactose via suppressing p38MAPK-dependent NF-κB activity.
Ginsenoside F2 , an active component of EG , increased procollagen type I production and decreased MMP-1 secretion in UV-irradiated human dermal fibroblasts.
Gintonin is a complex of glycosylated ginseng proteins containing lysophosphatidic acids ( LPAs ) that are the intracellular lipid mitogenic mediator.
Gintonin specifically and potently activates the G protein-coupled receptors ( GPCRs ) for LPA.
Girls also expressed less concern than boys that tanning caused immediate skin damage or premature aging.
Girls believed more strongly than boys that tanning improved their general appearance and that friends influenced their decision to tan.
Girls had a significantly lower vertebral BMF than mothers and fathers with both methods ( for all , p < @number@ ) .
Girls had higher pain tolerance and threshold at all temperatures.
Girls tend to have shorter eyes compared with boys.
GIS analysis revealed a stable longevity zone located in the center of the research region.
GI symptoms were present in @number@ patients with active ulcer ( s ) , while @number@ patients with smaller ulcer were asymptomatic.
Given age-related declines in physiologic reserve , the influence of POPs on thyroid hormones in aging populations may have clinical implications and merits further investigation.
Given are the rational combinations of medical drugs to be used when single-drug therapy is not effective enough.
Given a rodent's short gestational and developmental period , the effects of developmental exposure can also be readily addressed.
Given a series of risk-benefit profiles , respondents indicated whether they were comfortable with proxy consent to research for each scenario.
Given current trends of sharply increasing chronic disease incidence , economic disaster from the impending silver tsunami may be ahead.
Given evidence that psychological trauma adversely affects the brain , we hypothesized that the apoE genotype moderates effects of psychological trauma on PTSD pathogenesis.
Given its extensive use in clinical genetic screening , multiplex genetic testing is a promising tool in clinical cancer surveillance.
Given its high diagnostic relevance , the neuroautonomic evaluation should be routinely performed in older patients with unexplained falls.
Given its impact , a comprehensive multi-pronged approach to care , treatment and prevention is required to reverse the increasing trend that is observed worldwide.
Given its importance in memory and dementia , the ability to selectively modulate gene expression or neuronal function in the EC is of widespread interest.
Given longer survival on highly active antiretroviral therapy , further studies of these markers are needed to determine their prognostic value.
Given short , easy-to-use screening tools , risk groups can be identified in the primary care and referred to a specialised team for further treatment.
Given significant gender interactions between physical function and quality of life , separate analyses were conducted for men and women.
Given similar reliability and validity , the Quick EXIT is recommended clinically as it is briefer and less burdensome than the full EXIT.
Given that cardiovascular disease is the leading cause of death in postmenopausal women , the importance of weight management in midlife cannot be overemphasized.
Given that exercise programs help prevent frailty , promoting exercise in elderly may improve the prognosis of hip fracture.
Given that familiarity remains intact during healthy aging , this may be one route to reducing age-related associative deficits.
Given that most individuals are not at genetic risk , physical exercise may be an effective strategy for preventing dementia.
Given that MTL atrophy is a neuropathological hallmark of AD , retinal integrity may be an early marker of ongoing AD-related brain health.
Given that only three patients in this large cohort had evidence of prior surgery , it seems that most people adapt to trapeziometacarpal arthrosis.
Given that patients with this disease exhibit osteoporosis , the present study aimed to determine whether the WRN gene contributes to the etiology of osteoporosis.
Given that socioemotional functioning underlies appropriate behavior , socioemotional impairments may contribute to the appearance of behavioral disorders.
Given that stromal remodeling actively promotes BPH / PCa development , there is considerable interest in developing stromal-targeted therapies.
Given the aging of the U.S. population , the incidence of atrial fibrillation is expected to double within the next @number@ years.
Given the aging of the US workforce , keeping older workers healthy and productive will be crucial to remaining competitive in the global economy.
Given the aging population and the complex needs of older adults , there is considerable need for additional gerontological nurses.
Given the aging population in Australia , it is inevitable that paramedic attendance to this demographic of patients will also rise.
Given the aging population , polyneuropathy in general and CAP in particular will pose a growing health care problem.
Given the aging population , the prevalence of the disease is expected to increase substantially.
Given the beneficial role of such factors in periodontal disease , whether coffee intake is associated with periodontal disease in adult males was explored.
Given the biochemical versatility of RNA , lncRNAs may be used for various tasks , including posttranscriptional processing.
Given the broad impact of lncRNAs on gene regulation , there is escalating interest in elucidating the mechanisms that govern the steady-state levels of lncRNAs.
Given the central role of the thymus in tolerance , these facts have stimulated the interest in the biology of the thymus in humans.
Given the complexity of sepsis , biomarkers and mathematical models offer potential guidance once they have been carefully validated.
Given the current paucity of eligible APMs , this article will focus on MIPS while providing a brief overview of APMs.
Given the design characteristics of this trial , the present findings should be taken cautiously.
Given the detrimental effect of these metabolic abnormalities , a change in the lifestyle must be the cornerstone in the treatment of sarcopenia.
Given the effect of aging on functional capacity , self-management may be especially challenging for older patients.
Given the efficacy signal , a phase III trial is warranted.
Given the excess stress and hypertension experienced by African Americans , coping may be a particularly salient factor in longevity.
Given the functional proximity between these @number@ genes , we investigated the genetic variation of TYROBP in a Turkish cohort of @number@ dementia patients.
Given the growing number of older adults at risk for stroke , it is increasingly important to identify health behaviors that can produce significant change.
Given the growing number of older people in western society and the growing need for care , action to prevent functional decline cannot be withheld.
Given the health status of older adults with HD , interventions should target the prevention and management of medical conditions.
Given the heterogeneity of the included samples and interventions , in addition to the short-term follow-up , no firm conclusions can be drawn.
Given the heterogeneity within the older population , providing individualized care is pivotal to preventing ADRs.
Given the high association of liver transplantation with the metabolic syndrome , we hypothesized that liver transplant recipients may exhibit premature and accelerated aging.
Given the high economic and social pressure , anaesthetists will be requested to treat an increasing number of elderly as outpatients.
Given the high frequency of these disorders , the current results suggest that most older adults can benefit from an active lifestyle.
Given the high levels of inflammatory parameters found in depressed elderly patients , the \ "inflammaging \ " hypothesis is gaining strength.
Given the highly variable phenotype , diagnosis is challenging and particularly late-onset forms with predominantly neuropsychiatric presentations are likely underdiagnosed.
Given the high prevalence of comorbidities in these patients , interdisciplinary and interprofessional approaches are required.
Given the high proportion of persons recommended for treatment , NOF Guidelines may need to be re-evaluated with respect to budget impact.
Given the high proportion of persons recommended for treatment , NOF Guidelines may need to be re-evaluated with respect to budget impact.
Given the high rate of recurrent cardiovascular events in older adults , there is substantial potential for statin treatment to provide benefits in this population.
Given the high rate of smoking among HIV-infected patients , chronic obstructive pulmonary disease is another important cause of morbidity and mortality.
Given the high transplant-related morbidity , these treatment strategies were initially restricted to younger patients , but are increasingly being used in older adults.
Given the impact of ageing on arterial wall structure , the pressure-dependence of PWV may vary with age.
Given the importance of driving to mobility , quality of life , and public safety , more research is needed.
Given the importance of gamma oscillations in normal and disturbed cognition , there has been growing interest in their developmental trajectory.
Given the importance of hippocampal atrophy in Alzheimer's disease , it is imperative that techniques are developed for detection of TDP-43 in vivo.
Given the increased numbers of TJAs performed , additional research on prevention and management is critical.
Given the increasing levels of air pollution and its detrimental effects on the skin , it is advisable to use strategies to decrease air pollution.
Given the increasing rates of stroke and our aging population , it is critical that we continue to foster innovation in stroke rehabilitation.
Given the interpersonal nature of caregiving , the relationship between caregivers and care recipients may impact caregiver responses.
Given their specific needs , it is conceivable that these would be different for the oldest old compared to younger subjects.
Given the late onset of ND , smoking dependence may be a progressive disorder.
Given the limitations of conventional treatments , non-pharmacological treatments such as mindfulness-based interventions ( MBIs ) are gaining popularity for sleep ailments.
Given the limited evidence drawn mostly from cross-sectional studies , longitudinal studies are needed to further explore these associations.
Given the limited sample size , our approach uncovered genes and disease pathways associated with chronic alcohol consumption at the epigenetic level.
Given the nature of motor performance , the decline in the planning stage of motor execution may be associated with an expression of FoF.
Given the phenotypic changes associated with nutrient restriction , we hypothesized significant protein expression alterations must be associated with caloric restriction.
Given the potential advantages of early intervention for attention difficulties , the findings are of clinical as well as theoretical interest.
Given the primacy of the consumer in health care , their views must be central in the development of any deprescribing process.
Given the profound impact on public health , much research has focused on the age-specific risk of developing dementia and the impact on survival.
Given the profound interdependency of arterial stiffness and blood pressure , this question seems intrinsically challenging , or probably naïve.
Given the rapidly expanding therapeutic armamentarium for anti-aging modalities in dermatology , reports of KA secondary to invasive cosmetic procedures are on the rise.
Given the relative ease of PLM implementation , these data have important positive implications for PLM as a clinical vascular health assessment.
Given the rise in the average age , it is reasonable to hypothesize that the number of older prisoners is growing.
Given the rising rate of survival into advanced old age in the United States , achieving longevity and healthy aging is becoming increasingly important.
Given the roles of astrocytes in energy storage and brain immunity , we sought to characterize the transcriptome of AD PC astrocytes.
Given these aspects , individualized therapy for each elderly patient is needed to achieve acceptable risk-benefit ratio.
Given these circumstances , we conducted questionnaire surveys in @number@ to examine concerns in this age-group.
Given these findings , class II PI3Ks ( α and β isoforms ) were examined as potential positive regulators of autophagy.
Given these findings , it was quite reasonable to suppose that LRRK2 Pro755Leu variant rarely increased risk for PD in ethnic Chinese population in Asia.
Given these findings , strategies to locally regulate hormone bioavailability by altering pre-receptor metabolism may offer greater therapeutic potential in the fight against age-related disease.
Given these observations , there is much to be gained through the promotion of healthy lifestyles.
Given these results , health professionals and researchers should consider phenotype and gender differently when planning health services or future studies.
Given the serious nature of PJI , prevention efforts remain essential.
Given these risks , recent guidelines for the management of chronic pain in the elderly recommend using NSAIDs rarely and only in carefully selected patients.
Given the severity of these phenotypes we explored their functional impact in Drosophila.
Given the significant association of age with this trend , both diseases can be expected to increase for decades to come.
Given the similarity between monkeys and humans , hippocampal neurogenesis likely plays a similar role in the treatment of clinical depression.
Given the small number and poor quality of RCTs included in the meta-analysis , these results are inconclusive.
Given the strength of the empirical evidence , physicians should be confident in offering these products to their patients.
Given the strikingly low levels of social support , intervention strategies for CG should include components addressing social support.
Given the strong rationale for prevention , most adult immunisation guidelines include HZ vaccine , yet it remains underused.
Given the systemic nature of enzyme deficiency , we hypothesized that the stem cell compartment of GD and FD patients might be also affected.
Given the trend toward safer , less invasive treatments preferred by those patients reticent to undergo more invasive procedures , viable alternatives have been sought.
Given the worldwide aging demographics , this is a major contributor to morbidity , escalating socio-economic costs and ultimately mortality.
Given the worldwide incidence and prevalence of cancer , there is increasing interest in physical activity as a nonpharmacological intervention and prevention method.
Given the worldwide interest in natural antiphotoaging products , we investigated the protective effects of myrcene in UVB-irradiated human dermal fibroblasts ( NHDFs ) .
Given the worldwide public health impact of AD , novel interventions to reduce suffering experienced by AD patients need to be developed.
Given this , anti-inflammatory therapies may prove beneficial in improving neutrophil functionality in the elderly.
Given this confirmed finding , it is conceivable that polymorphisms in the other FOXO genes might have a similar effect on human longevity.
Given this effect of NRTI therapy on mtDNA replication , it is plausible that NRTI treatment may also lead to increased mtDNA mutations.
Given this , it is likely that reverberant energy interferes with selective auditory attention.
Given this pattern of economic productivity , delays in menopause would produce net economic deficits within families.
Given this , technologies to measure cardiac mitochondrial function are in demand.
Given this , the FFM domains and facets as embodied in the NEO PI-3 do not reflect aetiologically coherent traits.
Glabellar lines , crow's feet lines , and nasolabial folds showed the greatest change with age.
Glabellar line severity was evaluated by investigators and subjects at least every @number@ weeks , for at least @number@ weeks.
Glands preliminary have been stained by a solution @percent@ methylene dark blue with Sinelnicov's method and by hematoxilin and eozin.
Glasgow Coma Scale , revised trauma score , gender , and pretrauma FIM expression scores were predictive of survival in the geriatric trauma patient.
Glass-ionomer cement was bonded to the surfaces either with or without polyalkenoic acid conditioning.
Glass polyalkenoate cements ( GPCs ) containing aluminum-free borate glasses having the general composition were evaluated in this work.
Glaucoma affects millions of people around the world.
Glaucoma diagnostic codes were identified in the records linkage system of the Rochester Epidemiology Project.
Glaucoma is a complex disorder of aging defined by the death of retinal ganglion cells and remodeling of connective tissues at the optic nerve head.
Glaucoma is a progressive and chronic neurodegenerative disorder characterized by damage to the inner layers of the retina and deformation of the optic nerve head.
Glaucoma is one of the leading causes of blindness worldwide.
Glaucoma is the most common cause of irreversible blindness worldwide.
Glaucoma suspects had normal visual fields bilaterally.
Glaucoma was defined by specific criteria for optic disc damage and visual field loss in ≥1 eye.
GLaz beneficial effects persist throughout aging , and appears when expressed by degenerating neurons or by retinal support and glial cells.
GLaz modulates key autophagy genes and lipid-peroxide clearance responsive genes.
GlcNAc polymer-driven neurotoxicity offers novel pathogenic insights in sporadic AD and new therapeutic options.
GlcN and BAY alone had a negligible effect on the methylation status of the IL1B promoter.
GlcN dramatically ameliorated the cytokine-induced expression by 4-fold.
GLI1 and @date@ are known regulators of stem cell pluripotency.
GLI1 knockdown reduced SPP1 mRNA and protein levels in glioma cells.
Glial activation results in the sustained production of proinflammatory cytokines and reactive oxygen species , giving rise to a chronic inflammatory process.
Glial cells in their plurality pervade the human brain and impact on brain structure and function.
Glial cells play a critical role in neuronal support which includes the production and release of the neurotrophin brain-derived neurotrophic factor ( BDNF ) .
Glial HO-1 expression may also impact neuroplasticity and cell survival by modulating brain sterol metabolism and the proteasomal degradation of neurotoxic proteins.
Glial HO-1 suppression may attenuate bioenergetic failure and slow disease progression in AD and other neurodegenerative conditions featuring accelerated accumulation of CA.
GLIA @number@ ; 65 : 431-446.
GLIA @number@ ; 65 : 851-863.
Glia of the central nervous system ( CNS ) help to maintain homeostasis in the brain and support efficient neuronal function.
Glicentin is a proglucagon-derived peptide mainly produced in the L-intestinal cells.
Glides and gaps could be separated in 150ms , 250ms , 650ms or longer and the task was gap detection while ignoring glides.
Glioblastoma ( GBM ) is rare in early adulthood and little information is available on this subgroup.
Glioblastoma multiforme ( GBM ) is one of the most common and most aggressive types of primary brain tumors in humans.
Glioblastoma multiforme ( GBM ) is the most common adult primary malignant brain tumor.
Glioblastoma multiforme ( GBM ) is the most malignant primary brain tumor and more resistant to radiotherapy.
Glioblastoma multiforme remains one of the most intractable human malignancies.
Glioblastoma stem cells ( GSC ) are a significant cell model for explaining brain tumor recurrence.
Glioma is the most common form of primary brain tumor.
Gliomas are the most frequent brain tumors.
Gliomas are the most frequent primary brain tumors in adults.
Gln170 , which is located in another unstructured part of γS crystallin , showed a similar deamidation profile to that of Gln92.
Gln deprivation decreased cell proliferation as expected , but did not induce remarkable cell death.
Global AD likelihood index and surface-based likelihood maps were also generated.
Global analyses revealed an increase in the average non-linearity from fractional anisotropy to radial diffusivity , axial diffusivity , and mean diffusivity.
Global and local correspondence of Aβ and iFC were assessed within the posterior default mode network ( pDMN ) by within-subject voxel-wise correlations.
Global and local protein sequence alignments of over @number@ genes across at least @number@ mammalian species were examined to identify LAGs.
Global and medial temporal lobe ( MTL ) GM was also assessed.
Global and regional haemodynamic parameters were continuously recorded during the study.
Global appearance scores improved by @number@ and @number@ percent , respectively.
Global Assessment of Functioning ( GAF ) , psychotic symptoms , and mood symptoms were rated at each assessment.
Global burden measurements among autosomal chromosomes were investigated in cases vs controls.
Global changes in miRNA expression in skeletal muscle in response to endurance exercise training have been reported.
Global cognition , short term memory , speed of processing , executive function and sustained attention were measured by a detailed battery of neuropsychological tests.
Global cognition was measured at those visits with the Comprehensive Assessment and Referral Evaluation ( CARE ) .
Global cognition was tested by the Mini-Mental State Examinaton.
Global cognition was the best predictor of conversion to AD in low CR patients.
Global cognitive decline was defined as a reduction of ≥5 points on the Mini-Mental State Examination ( MMSE ) .
Global cognitive function and executive function were measured with standardized instruments , and saliva samples were collected for salivary estradiol and testosterone.
Global cognitive function , as measured by the MMSE , did not deteriorate in the two treatment groups.
Global cognitive function was evaluated with the Mini-Mental State Examination ( MMSE ) .
Global cognitive function was measured by the Mini-Mental State Examination ( MMSE ) .
Global cognitive function was measured with the cognitive ability screening instrument ( CASI ) , at four examinations spanning an 8-year interval.
Global cognitive performance , BPS , and ADL were assessed using validated clinical methods at baseline and at two-year follow-up.
Global connectivity of networks has been found impaired in clinical Alzheimer's disease ( AD ) compared to cognitively healthy aging.
Global estimates on aging predict an increased burden of asthma in the older population.
Global glomerulosclerosis with loss of podocytes in humans is typical of end-stage renal pathology.
Global hypomethylation occurs during SMC proliferation in culture and in vivo during neointimal formation.
Global hypomethylation of proliferating aortic SMCs and concomitant decrease of DNMT1 expression were identified in culture during passage.
Global inference generation requires the integration of textual information and world knowledge and can be expressed as a gist or lesson.
Global levels of 5mC and 5hmC positively correlated with each other and with markers of AD including amyloid beta , tau , and ubiquitin loads.
Global LV longitudinal , circumferential , and radial strain was compared between the two modalities.
Globally and in the Gulf Region , pneumococcal disease is an increasingly important public health burden in the elderly.
Globally , cardiovascular diseases ( CVDs ) are the number one cause of all mortalities.
Globally , during the last three decades , there has been an increasing incidence of the esophageal cancer , approx.
Globally , iron levels proved to be age-related.
Globally millions of people are suffering from this disease.
Globally , pneumonia is a serious public health concern and a major cause of mortality and morbidity.
Globally , results suggest an early and accelerated normal ageing process.
Globally , the 5-year range had an accuracy of @percent@ , increasing to @percent@ with the 10-year range.
Globally , the activity in obstetrics and gynecology will remain constant with an insignificant augmentation of @number@ acts ( @percent@ ) .
Globally , the attitudes of professional caregivers to ageing were more positive compared to the attitudes of older people living in institutions.
Globally , transversal studies showed a significant association between atrial fibrillation , cognitive decline and dementia.
Global measures of trunk sway are traditionally used even though the trunk comprises a multiple number of segments.
Global miRNA ( @number@ miRNAs ) measurements were performed as a screening to identify detectable miRNAs in plasma.
Global NMR metabolomics was used to elucidate differences in the metabolome between untreated and ( R , R' ) -MNF-treated cells.
Global peak systolic strain values were lowest in the youngest and oldest age groups.
Global task switching was found to add @number@ or more stages to processing and resulted in a marked age deficit.
Globoid cell leukodystrophy is a lysosomal storage disease characterized by the loss of galactocerebrosidase.
Glomerular diseases are common in elderly patients and are a major cause of kidney failure.
Glomerular diseases lead to a progressive decline in renal function and account for the vast majority of end-stage kidney diseases.
Glomerular epithelial stem cells generate podocytes during kidney growth and regenerate podocytes after injury , thus explaining why various glomerular disorders undergo remission occasionally.
Glomerular filtration rate ( GFR ) was estimated from age , sex and serum creatinine of the patient.
Glomerular filtration rate ( GFR ) was estimated on the basis of the age , sex and serum creatinine concentration of the patient.
Glomerular filtration rates were not available.
Glomerular kidney diseases are a major cause of end-stage renal disease ( ESRD ) .
GLP-1 analogues may be potential agents for the treatment of cardiovascular diseases.
GLP-1 level increased dramatically at @number@ @number@ and @number@ months , normalizing by @number@ and @number@ months.
GLP-1R and GCGR antagonists , and inhibitors of various signaling pathways were used in cell culture to characterize the mechanisms of action of OXM.
GLP-1R gene expression was silenced by siRNA.
Glucagon- and catecholamine-induced increases in plasma glucose level contribute to increase energy production.
Glucagon levels are classically suppressed after glucose challenge.
Glucagon levels were measured during OGTT in a total of @number@ individuals without diabetes in three large European cohorts.
Glucagon-like peptide-1 ( GLP-1 ) exerts multiple cardioprotective actions beyond insulinotropic effects through GLP-1 receptor ( GLP-1R ) .
Glucagon-like peptide-1 ( GLP-1 ) was infused during the last hour of the H-clamp.
Glucocerbrosidase mutation carriers were excluded.
Glucocerebrosidase ( GBA ) mutation carriers were excluded.
Glucocerebrosidase @number@ ( Although ERα activation properties have been intensively studied , this is not the case for their repressive properties.
Glucocorticoid Receptor ( GR ) is present in virtually every human cell type.
Glucocorticoid receptor ( GR ) transduces the glucocorticoid ( GC ) signal that could lead to metabolic derangements depending on the tissue responsiveness to GC.
Glucocorticoids ( GC ) in excess cause muscle weakness and atrophy.
Glucocorticoids have profound effects on brain development and adult CNS function.
Glucocorticoids play an important role in cognitive function and act on glucocorticoid receptors and mineralocorticoid receptors ( MRs ) in the brain.
Glucoregulatory hormones and metabolites were measured throughout the study.
Glucosamine ( Gluc ) is a drug used as an anti-inflammatory in moderate forms of knee arthrosis.
Glucose intolerance in the elderly is associated both with impaired insulin secretion and insulin resistance.
Glucose levels , particularly hyperglycemia , are associated with the premature onset of age-related diseases including CVD.
Glucose levels were not different with both interventions.
Glucose-lowering agents do not always blunt these changes , as these changes may be progressive leading to the end stage of renal disease.
Glucose lowering has not been shown to be associated with improved prognosis.
Glucose-mediated energy production in central nervous system ( CNS ) reduces in the elderly.
Glucose metabolism produces , by oxidative phosphorylation , more than @number@ times the amount of energy generated by aerobic glycolysis.
Glucose metabolism was evaluated by measuring HbA1c , fasting plasma glucose ( FPG ) , insulin levels , and HOMA-IR.
Glucose-stimulated insulin secretion was impaired following partial mtDNA depletion , but was normalised following treatment with glibenclamide.
Glucose tolerance declines with age , resulting in a high prevalence of type @number@ diabetes and impaired glucose tolerance in the elderly population.
Glucose tolerance was assessed using a @number@ g oral glucose tolerance test.
Glucose tolerance was impaired in both PGKBP3 and PGKmutBP3 mice.
Glucose tolerant test performance was also improved.
Glucose uptake was stimulated , and production suppressed similarly.
Glut1 and Glut3 are the principal transporters of glucose in osteoblasts , although Glut4 has also been implicated.
Glutamate dehydrogenase @number@ ( GLUD1 ) is a mitochondrial enzyme expressed in all tissues , including brain.
Glutamatergic AMPA receptors are of clinical significance in dementia because of their roles in mediating fast excitatory neurotransmission and other synaptic events relevant to cognition.
Glutamine-fructose @number@ phosphate aminotransferase ( GFAT-1 ) , the HP's key enzyme , is a target of the unfolded protein response ( UPR ) .
Glutathione depletion increased the rate of hemoglobin glycation in erythrocytes incubated with high glucose concentrations.
Glutathione ( GSH ) plays an important role in maintaining redox homeostasis inside cells.
Glutathione peroxidase activity was decreased in patients compared with controls ( P = @number@ ) and siblings ( P = @number@ ) .
Glutathionylation appears to be enzymatically catalysed or require a unique microenvironment.
Gluteus medius , gluteus minimus , tensor fascia lata , and iliopsoas muscle atrophy was scored using a standard scale.
Glx / NAA and Glx / Cr correlated with MSSS and fatigue score , and Glx / Cr with depressive score of MS patients.
Glycated haemoglobin ( HbA1c ) levels , fasting glucose and other biological and behavioural risk factors were also assessed at baseline.
Glycated haemoglobin was assessed using the Cation Exchange resin method.
Glycation , a non-enzymatic glycosylation of proteins , induces tissue damage in association with various diseases and aging phenomena.
Glycation can cause the clouding of the lens by inducing reactions crosslinking proteins.
Glycation dose dependently reduced HPDL attachment and cell spreading , indicating that the novel glycated gelatine substrate affects cell behaviour.
Glycation is an inevitable nonenzymatic covalent reaction between proteins and endogenous reducing sugars or dicarbonyls ( methylglyoxal , glyoxal ) that results in protein inactivation.
Glycation is a process closely related to the aging and pathogenesis of diabetic complications.
Glycation is one of the major processes responsible for skin aging through induction of the detrimental formation of advanced glycation end-products ( AGEs ) .
Glycation is the non-enzymatic glycosylation of proteins , nucleotides and lipids by saccharide derivatives.
Glycation is the process whereby sugars bind to the free amine residues of proteins.
Glycation may be a major mechanism behind age-related diseases.
Glycation of GST by methylglyoxal , fructose , and glucose in vitro was studied.
Glycation reaction is a recognized mechanism related to chronological aging.
Glycation refers to a nonenzymatic post-translational modification formed by the reaction of amino groups and reducing sugars.
Glycemic control ( HbA1c ) and insulin dose were monitored.
Glycemic measures included fasting plasma glucose ( FPG ) , 2-hour post-prandial plasmic glucose ( 2hPPG ) , GA and HbA1c.
Glycine and lysine levels increased significantly ( p < 0.05 ) with aging , regardless of gender difference.
Glycitin is a soy isoflavone that exhibits antioxidant , antiallergic , and anti-osteoporosis activities.
Glycogen synthase kinase-3 ( GSK-3 ) is increasingly implicated as playing a pivotal role in this amyloid cascade.
Glycogen synthase kinase-3 ( GSK-3 ) is one of the few signaling molecules that regulate a truly astonishing number of critical intracellular signaling pathways.
Glycogen synthase kinase-3β ( GSK3B ) and cyclin-dependent kinase @number@ ( CDK5 ) are the @number@ major protein kinases involved in abnormal phosphorylation of tau.
Glycogen synthesis is a major component of the insulin response , and defective glycogen synthesis is a major portion of insulin resistance.
Glycosaminoglycan composition , concentration and anticoagulant activity were determined.
Glycosaminoglycan content declines faster with age in septal cartilage than auricular cartilage.
Glycosaminoglycans ( GAGs ) and proteoglycans ( PGs ) are involved in various structural functions and physiological regulations in the skin.
Glycosaminoglycans ( GAGs ) are related to multiple biological functions and diseases.
Glycosylated hemoglobin ( HbA1c ) was the outcome.
Glycosylation is the posttranslational coupling of sugar chains to proteins or lipids.
Glycosylation patterns of AAT enriched fractions were found to be associated with chronological ( calendar ) age and they differed between females and males.
Glycyrrhizic acid ( GA ) and glycyrrhetinic acid ( GTA ) are specific chemical compounds that may be isolated from the licorice plant.
Glymphatic dysfunction may pay a hitherto unsuspected role in the pathogenesis of neurodegenerative diseases as well as maintenance of cognition.
GM3 lies in the same glycosphingolipid metabolic pathway as GlcCer , a substrate of the enzyme glucocerebrosidase , which has been associated with PD.
Gmed / min IMAT was related to stride width variability ( r = 0.30 , p < 0.05 ) .
GM genes appeared to be strongly conserved , with copy number variation in only four genes.
GM highlighted @number@ organoleptic attributes responsible for the sensorial profile of the AMW.
GM showed disease-specific alterations , when comparing bvFTD with AD patients , and these alterations were associated with cognitive deficits.
GM structural covariance networks were constructed by 3D T1-magnetic resonance imaging and seed-based analysis.
GMV , CBF and fALFF additionally showed components accounting for 3-5% of variability with significant age associations.
Gnaq is a member of G protein family and is rich in brain tissue.
GNE harbors two enzymatic activities required for biosynthesis of sialic acid in mammalian cells.
GN stimulated the phosphorylation of AMPK , acetyl-CoA carboxylase ( ACC ) , and sterol regulatory element-binding protein 1c ( SREBP1c ) in HepG2 cells.
Goal-directed behavior is well-known to show declines in elderly individuals , possibly because of alterations in dopaminergic neural transmission.
Goal-directed behavior requires that cognitive operations can be protected from emotional distraction induced by task-irrelevant emotional stimuli.
Goal @number@ of the National Plan to Address Alzheimer's Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease-related dementias by @number@
Goal setting in older patients may be complicated by communication difficulties related to hearing , cognition , expectation , and culture.
Goals of new treatment modalities are reduction of perioperative and postoperative comorbidities , better pathological work-up of the specimens and increased recurrence-free survival.
Goals , time , and resources should dictate the combination of which methods and databases are used.
GO annotation and IPA pathway analysis agree to these results.
GOLD Stages II and III remained independently associated with higher PAI-1 levels in a final regression analysis.
GOLD stages were independently correlated with body composition and body functionality scores ( model r2 = 0.073 ) .
Gold standard of treatment of acetabular fractures remains the open reduction and internal fixation.
Gold standard was the clinical diagnosis established after @number@ years of clinical follow-up.
Golf is a very popular activity , and estimates of hip torques during the golf swing have not been reported.
GOLT1A was overexpressed in breast cancer specimens and GOLT1A-specific siRNAs inhibited the growth of TamR cells.
GOLT1A was selected as one of the miR-378a-3p candidate target genes by in silico analysis.
Gomes et al. report that age-associated oxidative phosphorylation ( OXPHOS ) defects in murine skeletal muscle are biphasic.
Gomisin N ( GN ) is a phytochemical derived from Schisandra chinensis.
Gompertz growth curves show that Caspian seals achieve an asymptotic standard body length of 126-129 cm ( n = @number@ ) .
Gompertz's work played an important role in shaping the emerging statistical science that underpins the pricing of life insurance and annuities.
Gonadal hormones are crucial to optimal brain function during maturity and even senescence.
Gonadal hormones may influence cognitive function.
Gonadal hormones may influence cognitive function.
Gonadal hypofunction is significantly related with in-hospital mortality.
Gonadal steroids affect a variety of brain processes.
Gonadotrophins , but not sex steroid hormone levels , are associated with musculoskeletal pain in men.
Gonadotrophins , steroids , AMH , and inhibin B levels were measured during the follicular phase.
Gonadotropin administration to prepubertal rats stimulated ovarian follicular development associated with increased expression of the mitochondrial protein quality control system.
Gonarthrosis is one of the most serious diseases the highly developed modern medicine must face.
Gonial measurements were not as indicative as symphyseal distances.
Go / NoGo-P3 amplitude reductions in elderly were not related to an increased delta latency jitter.
Good acute pain control can be provided with multimodal analgesia , including regional anesthesia techniques.
Good adherence , defined as a medication possession ratio of ≥80% , was modeled using log-binomial regression.
Good agreement was found between repeated magnetic resonance measurements and between magnetic resonance PWVs and the gold-standard.
Good and moderate evidence was found for activity avoidance / restriction ( AA / AR ) being predicted by FOF and FSe respectively.
Good and moderate evidence was found for quality of life ( QoL ) being predicted by FOF and BC respectively.
Good clinical outcomes ( modified Rankin score = @date@ ) were achieved in @number@ of @number@ ( @percent@ ) patients.
Good control of changes in L-BMD in the postmenopausal phase might be associated with regression of CVD.
Good evidence also exists that physical activity may benefit people with long-term neurologic conditions.
Good evidence was found for depression predicting FSe.
Good / excellent results were found in @percent@ ( CASSEBAUM ) and @percent@ ( JUPITER ) .
Good functional outcome ( modified Rankin Scale , mRS < 2 ) was achieved in @number@ % after a median follow-up of @number@ years.
Good functional outcome was defined as discharge modified Rankin Scale score ≤2 and investigated in multivariable logistic regression.
Good health is important , but more in the sense of being pain-free than of being disease-free.
Good health is the most important factor to live independently in old age.
Good mobility was associated with higher initial score in the group with accelerating change but not with rate of decline.
Good mood improved after 6-9 weeks.
Good-quality , long-term , large longitudinal trials are needed to validate the role of ABPM for Chinese CKD patients.
Good repeatability was confirmed through test-retest measurements on @number@ subjects.
Good results were obtained during the study in skin hydration.
Good socioeconomic conditions and social networks were associated with greater likelihood of SSA-only and both-SA relative to non-SA or RSA-only.
Good therapeutic approaches are still in need to cure age related disorders.
Good to moderate correlation was revealed ( ICC = @number@ p < @number@ ) .
Good usability ratings were given to the cognitive exercises.
Go to the publisher's online edition of Traffic Injury Prevention to view the supplemental file.
Go to the Villanova website listed above to register for contact hour credit.
Gough's Weight of Evidence Framework and the Cochrane Collaboration's tool for assessing risk of bias were used.
Gout-free patients with no gout diagnosis within history were matched ( up to 5 : 1 ) to each patient with gout.
Gout is common in the elderly , affecting an estimated @number@ million people aged > @number@ years in the USA alone.
Governed by macrophages , the pathogenesis of DC may begin with subclinical inflammation leading to elastolysis and secondary lymphostasis.
Government funding increased from @percent@ in @number@ to @percent@ in @number@
Government initiatives on ' timely diagnosis ' aim to improve the rate and quality of diagnosis for those with dementia.
Government programs need to be developed to assist the Chinese oldest old ( especially widowed ) to live independently.
Governments globally are developing strategies to promote digital inclusion and indeed Internet uptake is increasing steadily , including amongst older people.
Governments have an enormous economic and political stake in the health of their populations.
GO-Y030 also induced cell death comparable to that induced by curcumin but at a 10-fold lower concentration.
GO-Y030 is a good lead compound for the development of useful compounds for practical cancer chemotherapy.
GO-Y030 was a much stronger inducer of apoptosis compared with curcumin.
GO-Y078 inhibits NF-κB transactivation , as well as expression of TP53 and DR5 more effectively than curcumin.
GP antibiotic prescribing rates were high for LRTI but lower for CAP ( mostly due to immediate hospitalisation ) .
GPER-selective ligands , as well as GPER knockout mice , have greatly aided our understanding of the physiological roles of GPER.
GPHN Δ2-3 causes a frameshift resulting in a premature stop codon ( p.V22Gfs 7 ) leading to haplo-insufficiency of the gene.
GP intervention managed to change dietary habits in elderly population , which is encouraging since elderly population is very resistant regarding lifestyle habit changes.
GP-LR models can be interpreted as a Bayesian probabilistic analogue to kernel SVM classifiers.
GPR44 was found to be necessary for the decrease in hair growth by PGD2 .
GPR55 internalization and signaling mediated by O-1602 was blocked by MNF in GPR55-expressing HEK293 cells.
GPRC5C mRNA expression and protein level were reduced in the islets from type-2 diabetic donors.
G protein-coupled receptor @number@ ( GPR40 ) is believed to be an attractive target to enhance insulin secretion in patients with type @number@ diabetes.
GPs and their co-workers should be also aware of the changing needs of the elderly regarding non-medical attributes of GP care.
GPs ' awareness of the mental and social facts of ageing was poorer compared to that of physical facts.
GPs perceived dementia as a stigma which was gradually being overcome but that stigma still hindered timely diagnosis.
GPs ' perceptions of dementia mapped onto current conceptualizations of stigma.
GPs were better at detecting MCI when memory or two and more MCI-domains were impaired.
GPx-1 ablation increased adhesion of leukocytes to cultured endothelial cells and CD68 and F4 / 80 staining in cardiac tissue.
GPx ( P = @number@ ) and MDA ( P = @number@ ) levels were increased in patients with PMO after the treatment.
G-quadruplexes are known to affect expression on the level of DNA , therefore whether they form on the expanded-repeat DNA constitutes an important biological question.
GR activity was lower in MCI and AD patients than in healthy aged subjects.
Grade 3-5 neutropenia and infection were observed in @percent@ and @percent@ of patients , respectively.
Grade A recommendation usually depends on consistent level @number@ evidence.
Grade B recommendation usually depends on consistent level @number@ and / or @number@ studies , or \ "majority evidence \ " from RCTs.
Grade C recommendation usually depends on level @number@ studies or \ "majority evidence \ " from level @date@ studies or Delphi processed expert opinion.
Graded concentrations of EACA were added to aliquots of the plasma pool before activating fibrinolysis with tissue-type plasminogen activator.
Grade D was observed primarily in elderly patients.
Grade III showed bony fusion.
Grade II showed prominent calcification or ossification on the outer margin of the joint without fusion.
Grade I showed fibrocartilage without degenerative change in the marginal region of the joint.
Grade @number@ neutropenia was the most common haematological toxicity and occurred in @percent@ of @number@ treatment courses.
Grade @number@ non-haematological toxicities included anorexia ( @percent@ ) and diarrhoea ( @percent@ ) .
Grade @number@ or more neutropenia and febrile neutropenia were observed in @percent@ and @percent@ of all patients , respectively.
Grade repetition was not associated with either behavior.
Gradient-echo echo planar images were acquired after bolus injection of gadolinium-based contrast agent ( CA ) .
Gradient echo MRI scans were available on @number@ non-demented participants ( mean age : @number@ ± @number@ years ) .
Gradual loss of tissue function ( or homeostasis ) is a natural process of aging and is believed to cause many age-associated diseases.
Gradually , as healing progressed , the wound impedance increased and finally reached the impedance of the undamaged skin.
Gradual modifications in the axial skeletal structures over time result in pathological disorders that generally occur later in an individual's lifespan.
Graft-vs.-host disease ( GvHD ) is a major complication of allogenic hematopoietic stem-cell ( HSC ) transplantation.
Grain distributions and densities were evaluated semiquantitatively using Gallyas-Braak stains and immunohistochemistry with AT8 and RD4 antibodies.
Grain production of rice ( Oryza sativa L. ) is a top priority in ensuring food security for human beings.
Gram-stained specimens were evaluated for BV using the Nugent score as well as presence of Candida.
Grandchildren and nieces / nephews provided care for older care recipients.
Grandparenting and parenting an adult child were motivational for sustaining abstinence and reduced drinking.
Grandparenting is an increasingly popular form of childcare that provides social activity for older adults.
Grandparents separated geographically from their grandchildren develop new means of communication with them and new kinds of relationships.
Granger causality ( GC ) was used for analyzing the causal relationships between the LFOs observed in ABP , oxy-hemoglobin , and HR.
Granular deposits were seen over the surface of Biodentine and MTA Plus.
Granules do not appear to have an astrocytic origin , since although some Aβ clusters are associated with astrocyte processes , most clusters are not.
Granuloma after gels containing microparticles were treated using an 808-nm diode laser using intralesional laser technique.
Granuloma formation has never been reported in patients with GNE myopathy.
Granzyme B expression and cytokine production ( TNFα , IFNγ ) were increased in aMCI but not in mAD.
Grape juice has long been used worldwide for its potent medicinal values including ocular promotion.
Graph-based analysis has been used to estimate functional brain network efficiency and effects of normal aging on small-worldness have been reported.
Graphed perineometer sessions demonstrated high compliance and improvement in exercise technique.
Graph models may allow us to distinguish previously indistinguishable effects related to HIV and age on FC.
Graph theory models can produce simple , biologically informative metrics of the topology of resting-state functional connectivity ( FC ) networks.
Graph theory provides a powerful method to quantitatively describe the topological organisation of brain connectivity.
Grasping is a complex action which requires high-level motor control.
Gravidity , amenorrhea , and nadir total lymphocyte counts associated with higher AMH ; hormonal contraceptive use and past weight loss associated with lower AMH.
Gray and white matter volumes decrease markedly by the 7th decade of life when cognitive decreases first become readily detectable.
Gray divorced and never-married women face considerable economic insecurity.
Graying is the process in which distinct mechanisms lead to deterioration of the hair follicle melanocyte population.
Graying of hair is usually progressive and permanent , but there are occasional reports of spontaneous repigmentation of gray hair.
Gray matter density ( GMD ) , a measure often assumed to be highly related to volume , has not been systematically investigated in development.
Gray matter loss in cortical regions is a normal ageing process for the healthy brain.
Gray matter volume in left RLPFC , which decreased with age , partly accounted for changes in fixed PFC connectivity.
Gray matter volume of regions related to autonomic function was measured.
Gray matter volumes in these regions mediated the effects of age on semantic clustering.
Gray scale levels ( GSLs ) of muscle and subcutaneous fat were then measured by @number@ analysts : a trained research assistant and a radiologist.
Great advances have been made in both basic and clinical research.
Great effort has been dedicated to mapping the functional architecture of the brain in health and disease.
Great efforts have been made in studying biological correlates of dementia.
Greater adherence to the WHO guidelines is associated with greater longevity in elderly men and women in Europe and the United States.
Greater age , once-daily dosing , and lower renal function ( estimated glomerular filtration rate ) were independently associated with a lower lithium dose-concentration ratio.
Greater age-related degradation was evident in the anterior than posterior limb and in the superior than inferior division of the internal capsule.
Greater anatomic understanding of the pathogenesis of aging changes in the lower eyelid has led to more anatomically conservative and appropriate cosmetic surgical treatments.
Greater android adiposity stores were robustly associated with IR or diabetes in all adults , independent of SB and activity.
Greater anterior cingulate cortical thickness was also predictive of greater apathy , suggesting an underlying reactive process.
Greater attention should be paid to the construction of the pension system and the replenishment of the village doctors with qualified medical graduates.
Greater average reported frequency of social exchanges characterized by strain or conflict was negatively associated with executive function but not episodic memory.
Greater awareness that UI is a treatable condition and not a normal part of ageing is needed in the population and among health professionals.
Greater baseline CIMT was also independently associated with the development of MCI in the subjects whose baseline cognitive function was normal.
Greater baseline IIV was consistently associated with increased risk of adverse outcomes including cognitive decline or impairment , and mortality.
Greater cervical VEMP latency was associated with slower usual , rapid , and narrow gait speed in women but faster rapid gait speed in men.
Greater changes occurred in the female profile than the male profile.
Greater cumulative reproductive burden may lower calcaneal BMD individually and jointly with other lifestyle and heritable factors.
Greater @date@ Phi1 , and Phi ( TOT ) among AA were independent of S ( I ) .
Greater disparities were observed by race and nativity demonstrating some of the ways that TB incidence is socially patterned.
Greater diurnal decline of the HPA axis is associated with better physical performance in later life.
Greater dual-task costs in velocity ( p < @number@ ) were observed in WWC compared to WWR.
Greater efforts are needed to promote the benefits of these technologies and to support their use among older people with hearing loss.
Greater efforts are needed to understand barriers to effective pain management and self-management in the older population.
Greater efforts are required to improve awareness of VTE and improve standards of VTE prevention in healthcare organizations.
Greater efforts must be made to encourage and support PA participation in this population.
Greater focus on integrated , concurrent treatment for MDD and chronic physical diseases in the middle-aged and elderly is also required.
Greater height and weight , and smaller waist circumference are independently associated with greater HGS in females but not males.
Greater HI also influenced consultation and adoption of hearing aids.
Greater impairment was associated with higher percentage of work missed.
Greater improvement was significantly related to a higher level of baseline social support.
Greater incidence of dementia was found with more-rural residence and poorer economic status.
Greater increases were observed in the oldest age group ( ≥85 years ) .
Greater initial control predicted weaker declines in health and stronger increases in support.
Greater insight was found to be associated with depressed mood and anxiety.
Greater involvement of community-based palliative care may improve the dying experience for this complex population.
Greater local sweat rate and cutaneous vascular conductance were observed with fan use in aged adults.
Greater loss in grey matter volumes in ɛ4 + participants were accompanied by greater increases in lateral , third , and fourth ventricular volumes.
Greater marital satisfaction was associated with greater interpersonal enjoyment.
Greater mean iEMG was seen in CPA , with heavy ball , and for posterior trunk muscles ( p < .05 ) .
Greater muscular strength was observed in younger compared to older men and women on all tasks ( P < 0.05 ) .
Greater need for cognitive compensation was related to lower cognitive ability only for older wives.
Greater neuropathologic concordance was found for β-amyloid than tau pathology within the pairs.
Greater numbers of inmates are aging and dying in prison , creating a demand for enhanced end-of-life ( EOL ) care.
Greater optimism and satisfaction were also associated with educational achievement across generations.
Greater pain frequency in knee was found in more experienced and older age dentists ( P = @number@ ) .
Greater precaution , therefore , is needed when comparing sEMG patterns of less than @number@ years of age patient and TD children.
Greater predicted vs measured REE was noted after the intervention ( P = @number@ ) .
Greater preoperative ECD and larger donor tissue size are associated with higher ECD at @number@ years.
Greater psychosocial adversity in childhood is associated with poorer physical capability , independently of social disadvantage in childhood.
Greater Purkinje cell axonal remodeling ( torpedoes ) was found in individuals who had the most Purkinje cell drop out.
Greater range of motion ( ROM ) favoring the cable machine was also evident ( p < @number@ ) .
Greater self-neglect severity was associated with a greater increase in the rate of emergency department utilization.
Greater SH severity is associated with a decrement in overall dual-tasking ability in AD.
Greater social support was associated with better performance in the same domain ; this relationship was diminished by the presence of the ε4 allele.
Greater success with these agents clinically is expected when combining the agents with inhibitors of other cell signaling pathways in which cross-resistance has been observed.
Greater tactile experience was associated with the provision of richer descriptions of textured materials manipulated with the digits.
Greater total sleep time and sleep stage transitions were also significant objective correlates of subjective sleep quality.
Greater treatment intensity did not correlate with longer survival ( r = -0.04 ; P = 0.66 ) .
Greater trochanteric bursitis was graded none , mild , moderate , or severe.
Greater understanding of cell and molecular responses to estrogens can provide further insights into the findings of clinical studies.
Greater understanding of their impact on age patterns of suicide can result in potential preventive solutions.
Greater US acculturation , however , was associated with a slightly decreased diabetes rate.
Greater use of self-blame and denial coping was associated with lower positive affect for older adults and higher negative affect across the age range.
Greater variability in GVC5 was associated with longer DM duration and more depression.
Greater WMH volume was associated with poorer brain integrity measured from diffusion tensor imaging ( DTI ) in the corpus callosum and sagittal stratum.
Greatest hysteresis was observed in formulation containing HPMC.
Great progress has been made in understanding potential mediators between major depressive disorder and CVD both health behaviors and shared biological risks such as inflammation.
Great strides have been achieved in understanding the pathogenesis and potential therapeutics of ED over the past two decades.
Greece resides in the Mediterranean basin , and older generations traditionally adhere to a MeDi.
Greek-born widows displayed higher levels of mourning rituals , continuing bonds and religiosity than the British.
Greek widows also reported worse self-rated health , and increased symptoms of depression and loneliness compared to the British.
Green tea , among many health benefits , demonstrated protection from ultraviolet-induced events , such as photoimmunosuppression and skin cancer growth.
Green tea consumption is known to slow down the progress of aging.
Grey matter ( GM ) concentrations were determined using VBM.
Grey matter volumes of patients with Lesch-Nyhan variant disease were invariably between those of patients with classic Lesch-Nyhan disease and healthy controls.
\ "Grey zone \ " values falling within a ±20% interval around this limit need further clarification.
GR / GPx activity ratio was calculated to better assess antioxidant defenses.
Grief among older adults is most strongly predicted by perceived stigma around HIV and AIDS and worries about providing the care.
Grief was more intense when staff-patient relationships were closer , care was provided for longer , and staff felt emotionally unprepared for the death.
Grinding and polishing methods may result in changes in the surface characteristics of zirconia.
Grip strength also increased weakly with increasing WC.
Grip strength and pinch strength as well as gross dexterity and fine dexterity were assessed.
Grip strength , as measured by a handheld digital dynamometer , was used as an indicator of muscle strength.
Grip strength assessment by hydraulic dynamometry is useful in patients with poor collaboration.
Grip strength increased in both the left ( @percent@ ) and right ( @percent@ ) hands ( P < @number@ for each ) .
Grip strength is often considered an indicator of general vitality and , as such , may predict cognitive functioning.
Grip strength is recommended as a good simple measure of muscle strength when ' measured in standard conditions'.
Grip strength performance was associated with change in the @number@ cognitive abilities after age @number@ years.
Grip strength performance was followed in @number@ participants who were 50-88 years of age at baseline.
Grip strength was assessed by hydraulic dynamometer.
Grip strength was measured using a hand dynamometer with the dominant hand.
Grip strength was measured using the standard protocol applied in the Groningen Elderly Tests.
Grip strength was not associated with TMIG-IC score decline.
Grip strength was not predictive of 2-year mortality in this group.
GRK dysfunction also promotes a deleterious cycle that further increases β-amyloid accumulation and exaggerates tau hyperphosphorylation in the hippocampus.
GRM7 , ANGPT4 , and LRFN5 have been previously implicated in psychiatric disorders , including the GRM7 region displaying association with major depressive disorder.
GRN + / A152T + and GRN + / A152T- patients shared similar clinical and neuropsychological features and plasma progranulin levels.
GRN expression was upregulated in rs1990622 ( AA / AG ) carriers , and was associated with more advanced TDP-43 pathology.
Grocery purchasing was measured using a sixteen-item index of compliance of food purchasing with dietary guidelines.
Groin hernias are very common , and surgical treatment is usually recommended.
Gross and microscopic cerebral infarcts and hippocampal sclerosis were also identified.
Gross infarcts were associated with T ( @number@ ) prolongation in white matter of all lobes , and in the thalamus and basal ganglia.
Gross morphologic changes in comorbid Aβ and stroke rats were enlargement of the lateral ventricles with concomitant shrinkage of the hippocampus.
Gross morphologic differences may exist between these fat depots , but this has never been established at the cellular level.
Gross total removal of the lesions was achieved in @percent@ of the cases using this approach.
Grounded theory methods guided our data collection and analysis.
Ground-reaction force ( GRF ) and EMG quantified kinetics and neuromuscular activity.
Ground reaction forces ( GRFs ) ( mediolateral ( ML ) , anteroposterior ( AP ) components , vertical ( V ) ) were recorded.
Ground reaction forces were measured during sit-to-stand and counter-movement jump.
Group 3 : a @percent@ CH solution was applied before bonding with Panavia F2.0.
Group 4 : after CH application , the primed dentin was coated with a resin layer before cementation with Panavia F2.0.
Group 5 : ( control ) after applying Optibond Solo Plus , the inlays were cemented with Nexus @number@
Group 6 : after etching , CH was applied , and cementation was performed similarly to group @number@
Group A : 18-20 years , group B : 30-35 years , group C : 45-50 years.
Group × Age significantly interacted on cortical , but not subcortical gray matter volumes.
Group × Age significantly interacted on span accuracy ; advanced age related to diminished performance in typical adults , but not in adults with SBM.
Group allocation was not actively disclosed to participants and outcome assessors were masked to group allocation.
Group analyses of cortical thickness were performed using voxel-based statistics.
Group A patients then underwent full ablative laser treatment , and group B received fractionated ablative laser treatment.
Group A patients were pretreated with the full ablative laser and group B patients with a fractional ablative laser to the full face.
Group A performed conventional physiotherapy , while Group B performed sling training exercises.
Group A showed significant improvement in IPSS and OABSS with a significant increase of FT level , whereas group B showed no significant change.
Group A was treated using hyaluronic acid gel ( Restylane ; Q-Med , Uppsala , Sweden ) and a reinforced 25-gauge Pix'l + micro cannula.
Group-based trajectory modeling ( GBTM ) identified patterns of change in PA and body composition variables.
Group-based trajectory modelling was used to identify clusters of individuals with a similar pattern of psychological distress over time.
Group B streptococcus ( GBS ) is a major pathogen.
Group comparison results showed opposite profiles of SM activation for the two groups ; novices showed activation and the experts showed deactivation of the SM.
Group comparisons were performed on hippocampal volume , morphology , hippocampal seed-based functional connectivity , memory and executive function and self-ratings of memory proficiency.
Group differences also interacted with age differentially across the auditory pathway ; brainstem responses became larger and cortical ERPs smaller with advancing age.
Group differences and gains were maintained across time.
Group differences between combat and non-combat men were examined.
Group differences in change from baseline to 1-year follow-up were non-significant for all outcomes.
Group differences in cortical thickness and GM volumes were assessed using ANCOVA.
Group differences in deep gray matter volumetry and cortical thickness were studied.
Group differences in ( @number@ ) C-PBR28 binding were compared using @number@ methods.
Group differences on the 3MS were driven by language / executive and language / praxis factors.
Group differences were assessed using an analysis of covariance , controlling for adult height , weight , sex , and physical activity levels.
Group differences were more apparent for AC than WC conditions.
Group differences were not statistically significant after adjusting for comorbidities.
Grouped and ungrouped type I myofibers were evaluated for phenotypic differences.
Group functional connectivity magnetic resonance imaging ( fcMRI ) studies have documented reliable changes in human functional brain maturity over development.
Group I consisted of @number@ patients , ≥ @number@ years old ; Group II consisted of @number@ controls , < 65 years old.
Group I had @number@ cases of atypical meningiomas ( @percent@ vs @percent@ , ns ) .
Group II-VI semiconductor quantum dots ( Q-dots ) have found various applications in biomedical field during last decade.
Group II was stimulated according to the international standard protocol via rhTSH injections for two consecutive days.
Group-mean Dm / Vc was greater after vs. before exercise in the YNG and OLD subjects.
Group meetings which included protein-rich snacks strengthened the nutritional message by enabling discussions and socialising.
Group NOP had normal bone mineral density ( BMD ) and group OP low BMD.
Group @number@ and DED presented DC density significantly higher compared with group @number@ ( P < @number@ ) .
Group @number@ consisted of @number@ healthy elderly subjects ( M = @number@ SD = @number@ years ) .
Group @number@ consisted of @number@ healthy younger subjects ( M = @number@ SD = @number@ years ) .
Group @number@ ducts were larger at baseline than in the other groups ( P < @number@ ) .
Group @number@ exercised these mechanisms of dynamic stability and muscle strength.
Group @number@ is characterized primarily by soft tissue ptosis of the upper eyelid , which requires surgical excision.
Group @number@ ( n = @number@ ) received combined treatment with the above modalities in the same doses and duration.
Group @number@ ( n = @number@ ) received @number@ intramuscular injection of testosterone undecanoate.
Group @number@ ( n = @number@ ) received on-demand monotherapy with vardenafil for @number@ weeks.
Group PA correlated with MNA-SF score ( P = @number@ ) .
Groups based on total cholesterol ( TC ; ≥200 vs. < 200 mg / dl ) were compared with regard to NPS.
Groups conditioned using silica coating and silanization showed higher bond strengths both in dry and aged conditions.
Groups consisted of language-variant AD , visual-variant AD and AD patients with amnestic and dysexecutive deficits.
Groups did not differ on ADAS-Cog difference scores.
Groups differed in age , and both employed groups more frequently reported MSDs in all body areas.
Groups @number@ and @number@ simulated a situation with a compromised implant position that required an angulated ( 15-degree ) abutment.
Groups of data for cross-media color matching with different age were established to investigate the response of photoreceptor cells.
Groups of five amino acids , three plasmalogens , and two carnitines were also observed.
Groups of offspring and controls were similar with regard to sex distribution , age , and body mass index.
Group status was not associated with HSA or unmet needs.
Group study is required to formally test these findings.
Groups were comparable for clinical and neuropsychological measures.
Groups were compared by one-way ANOVA.
Groups were defined as patients aged @number@ years or older and patients younger than @number@ years.
Groups were matched on a critical confounding variable , alcohol use , to a far greater degree than in previously published studies.
Groups were otherwise comparable for clinical measures and distribution of APOE4 genotype.
Groups with participants who were aged 18-24 , 25-34 , 35-44 , 45-54 , 55-64 , and > @number@ years were compared.
Group-wise comparisons were made with regard to demographic characteristics , motor symptoms , neuropsychological performances and 18F-fluorodeoxyglucose positron emission tomography.
Groupwise comparisons were used to examine differences between patients and the comparison group and adult and geriatric BD cohorts.
Growing attention and comprehensive countermeasures involving psycho-social and personal activities might alleviate the sleep problem in the elderly.
Growing attention on oxidative stress and epigenetics will provide more important clues for the better understanding of the age-related OA.
Growing disparities in adult mortality across U.S. states point to the importance of assessing disparities in other domains of health.
Growing evidence implicates aberrant lipid signaling in Alzheimer's disease ( AD ) .
Growing evidence indicates that L-PHP expression in the pancreas may play a pivotal role for pancreatic development in the early prenatal period.
Growing evidence indicates that the global aging process is more malleable than used to be thought.
Growing evidence in vitro suggests a role for polyamines in enhancing differentiation in both adult stem cells and differentiated chondrocytes.
Growing evidence reveals that basal autophagy is an essential in vivo process mediating proper vascular function.
Growing evidence shows that AD targets cortical neuronal networks related to cognitive functions including episodic memory and visuospatial attention.
Growing evidence shows that leucine regulates protein and lipid metabolism in animals.
Growing evidence suggests that cognitive training programs may have the potential to counteract this decline.
Growing evidence suggests that Filipino Americans have higher rates of diabetes than non-Hispanic whites.
Growing evidence supports the existence of sensory-dependent knowledge in young individuals , but this question remains unexplored in elderly individuals.
Growing healthcare costs have caused home-care providers to look for more efficient use of healthcare resources.
Growing old as a woman.
Growing scientific evidence of reproductive physiology supports the role of melatonin in human reproduction.
Growth and somatic maintenance are thought to be antagonistic piciotropic traits , but the molecular basis for this tradeoff is poorly understood.
Growth as observed in DTI-derived scalar invariants is modeled with a parametric function , its parameters being input to NLME population modeling.
Growth-curve analyses were used to examine longitudinal change in perceived goal status.
Growth curve modeling was performed to examine trajectories of a global physical performance score across time as conditioned by cognition and depression.
Growth curve modeling was used to determine the effect of age and cohort on depression trajectory.
Growth curve modeling was used to examine the overall linear trajectories of sleep quality.
Growth-curve models revealed that distance to death was more predictive of declines in life satisfaction than chronological age.
Growth factors are a new category of ingredient found in modern cosmeceutical formulations.
Growth hormone levels were significantly higher in juvenile than in senescent rats , suggesting that growth hormone might promote host liver repopulation.
Growth hormone peak was > 3 µg / L in @percent@ , and cortisol peak was > 18 µg / dL in @percent@ of patients.
Growth inhibition of the small intestinal mucosa by fasting in mice was associated with increased CELF1 / Myc mRNA association and decreased MYC expression.
Growth in the demand for health workers will be highest among upper middle-income countries , driven by economic and population growth and aging.
Growth in turn depends on metabolism as it requires energy.
Growth kinetics , telomere lengths , and expression of cell cycle regulators showed significant variation between hCPC isolated from multiple patients.
Growth , maturation and body composition : the Fels longitudinal study 1929-1991.
Growth of cancer cells was inhibited by either direct interaction with Spalax fibroblasts or with soluble factors released into culture media and soft agar.
Growth of the axial length is mainly caused by increasing axial length of vitreous cavity.
Growth parameters have been assessed annually until the completion of growth.
Growth rates more than @percent@ per year correlated with surgery , without statistical significance in this small population ( P = 0.14 ) .
Growth was assessed at EDD , and at @number@ @number@ and @number@ months corrected age.
GRP78 is a major endoplasmic reticulum chaperone as well as a master regulator of the unfolded protein response.
GR promiscuity and crosstalk with other signaling pathways is discussed , alongside novel roles for GR that include mood disorder and addiction.
GR resulted in an increased expression of SIRT1 , a NAD-dependent histone deacetylase , which has positive correlation with CR-induced longevity.
GRSrate was linearly related to SUArate only among men.
GRSs were constructed on the basis of @number@ single-nucleotide polymorphisms previously associated with Alzheimer's disease ( AD ) .
GRSs were constructed with @number@ single-nucleotide polymorphisms implicated in stroke and @number@ risk factors.
GS alone could be used routinely as a marker of early death to adapt oncologic therapeutics.
GS alone < @number@ m / s is at least as efficacious as the SPPB in predicting this outcome.
GSH and collagenases were analyzed , and the expression of inducible Nrf2 , HO-1 , and NQO1 was measured.
GSH synthetase and CRYAB expression levels in the nuclear cataract decreased with age.
GSIs and GSMs reduce Aβ levels through very different mechanisms.
GSIS scores significantly differentiated between participants with as compared to those without a history of suicide behavior.
GSR is a measure of the degree of adaptation an individual makes to increase stability during gait derived from a ratio of cadence / velocity.
( GSS ) is an autosomal dominant neurodegenerative disease due to mutations within prion protein ( PRNP ) gene.
G-tail telomere HPA may be applicable for clinical diagnostics as well as drug target screening.
GTP cyclohydrolase @number@ encoded by the GCH1 gene , is an essential enzyme for dopamine production in nigrostriatal cells.
GTP-independent membrane tethering through L-OPA1 and CL primes the subsequent GTP-hydrolysis-dependent fusion , which can be modulated by the presence of S-OPA1.
Guardians for @number@ patients in the steroid group withdrew their consent , and @number@ patient in the propranolol group did not complete the efficacy test.
Guided by a community-based participatory research approach , a total of @number@ Chinese older adults aged @number@ and above were surveyed.
Guided by a community-based participatory research approach , a total of @number@ Chinese older adults aged @number@ and above were surveyed.
Guided by case study methodology , we gathered data through semi-structured interviews and patient logs.
Guided with this atlas , we then developed a fully automated method for WMSA detection and quantification using T2-weighted images.
Guidelines for an \ "exercise prescription \ " for frail older adults are briefly outlined.
Guidelines for clinical assessment will be presented in this scoping review.
Guidelines for prevention of catheter-acquired urinary infection should be followed.
Guidelines for the prevention of falls were first developed by the Korean Association of Internal Medicine and the Korean Geriatrics Society.
Guidelines for VHD management recommend interval monitoring with echocardiography.
Guidelines from scientific societies mainly address the quantitative aspects of protein and energy nutrition in elderly.
Guidelines meeting inclusion criteria were evaluated using the Appraisal of Guidelines for Research and Evaluation II instrument.
Guidelines that will assist the home healthcare provider in promoting a safe and comfortable environment are discussed.
Guidelines to define when IHC workup is necessary and not necessary may be helpful to guide workups.
Guides are also available to help clinicians discuss stopping screening with older women with less than a 10-year life expectancy.
Guiding principles to help ensure that resources such as kidneys are justly allocated across the life span are proposed.
Guilt increased from adolescence into old age , reaching a plateau at about age @number@ years.
Gustation was normal in all subjects , and there was no significant difference between younger and older groups.
Gut permeability was assessed by the dual-sugar absorption test.
GV1001 is a 16-amino-acid vaccine peptide derived from the human telomerase reverse transcriptase sequence.
GV1001 protected NSCs against the Aβ₂₅₋₃₅ oligomer in a concentration-dependent manner.
GvHD is associated with loss of endothelial thrombomodulin , but the relevance of this for the adaptive immune response to transplanted HSCs remains unknown.
GVS resulted in both age-groups to reduce head movement.
GWAS and candidate gene studies conducted in women of European ancestry have identified @number@ loci associated with age at menopause.
GWAS data will be used for exploratory analyses to identify any genes associated with stress and CVD.
GWIR was not able to differentiate between normal aging , MCI , and AD.
Gynaecological and obstetric complications worsen with age.
Gynecologic symptoms more likely have multiple contributing factors than one etiology.
H2 can be monitored with an H2-specific electrode or by gas chromatography.
H2O2 markedly induced BLVRA activity in young HDFs , but not in senescent HDFs.
H2O2 transport across membranes is facilitated by aquaporins , denoted as peroxiporins.
H2O2 treatment decreased Gnaq expression but increased NF-κB and p-Erk1 / 2 expressions in Gnaq-SY5Y cells.
H2 rapidly diffuses into tissues and cells to exhibit efficient effects.
H2S also shows a potent regularizing effect against fatal arrhythmia in a rat model of myocardial infarction.
H2S broke the disulfide bridge between a pair of oxidized cysteine residues ; however , it did not modify single cysteine residues.
H2S extended action potential duration in epicardial myocytes and regularized fatal arrhythmia in a rat model of myocardial infarction.
H2S is a gas easily identified by its distinctive odor.
H2 S is produced by cystathionine γ-lyase ( CSE ) , cystathionine β-synthase ( CBS ) and 3-mercaptopyruvate sulfurtransferase ( 3-MST ) .
H3 histone modifications were declined in P66SHc gene regulating region.
H3K27me3 loss is correlated with up-regulation of key senescence genes , indicating a link between global chromatin changes and local gene expression regulation.
H4 lysine @number@ was acetylated at @number@ h post-serum stimulation while there was no change in acetylation of lysine @number@
H67D-HFE mice also had a greater reduction in brain volume and poorer recognition and spatial memory than WT-HFE mice , symptoms associated with AD.
HA5 LS was also well-tolerated and highly-rated by subjects throughout the study duration.
HAART administration in the ICU can be challenging due to limited delivery routes , concern for viral resistance and medication toxicities.
HAART reduced AIDS-defined-malignancies ( ADM ) , but incidence of several non-ADM is increasing.
Habitual aerobic exercise is an effective lifestyle strategy to reduce central arterial stiffness and is related to lower risk of cognitive impairment.
Habitual coffee consumption in large epidemiological studies is associated with reduced mortality , both for all-cause and cardiovascular deaths.
Habitual consumption of dairy products has been shown to play an important role in the prevention of several chronic diseases.
Habitual endurance exercise may provide partial protection to the endothelium against this form of I / R injury with advancing age.
Habitual energy intake ( HEI ) was also determined.
Habitual exercise is associated with improved VEF and reduced CVD risk.
Habitual physical activity and sedentary time were measured using accelerometry.
had any history of coronary artery disease and all underwent detailed transthoracic echocardiography , including speckle tracking derived strains.
had cardiac diseases or experienced cardiac events during 1-year follow-up.
had WDR45 mutations.
Haematopoietic tissue expression validates using zebrafish for MLL haematopoiesis and leukaemia models.
Haemoglobin concentration may need a different cut-off in heart failure for a reason other than paradox.
Haemoglobin content was not associated to immunosuppression.
Haemoglobin modification was not different between both RBC groups.
Haemoglobins are iron-containing proteins that transport oxygen in the blood of most vertebrates.
Haemolysis rate on day + 42 was higher in RTH-RBCs than in RC-RBCs ( 0·52 ± 0·13 vs. 0·37 ± 0·12% ) .
Haemophilic arthropathy is common in elderly PWH.
HA fillers are considered to be safe , although some complications can occur.
HA fillers are longer lasting , less immunogenic and can be broken down by hyaluronidase.
H Aging is a natural process of declining organ function and reserve.
Hair and pigmentary disorders are common , and aging-related damage is most visible in the periorbital area.
Hair As level has a median @number@ ( min : @number@ and max : @number@ ) .
Hair As levels were detected by a hair analysis ( Varian AA240Z Zeeman Atomic Absorption Spectrometer , USA ) .
Hair cortisol concentrations were determined from the scalp-nearest @number@ cm hair segment , and height , weight , and waist circumference were objectively measured.
Hair density declined with age , especially at the peak between the top and back.
Hair density , thickness and the white hair percentage were measured via phototrichogram.
Hair follicles played a significant role as a pathway for transport of coumarin according to the examination of follicular accumulation.
Hair follicle stem cells also participate in recurrent , long-lasting cycles of regeneration : the hair growth cycles.
Hair graying , recession of hair from the forehead and lip height were influenced mainly by genetic factors whereas environmental factors influenced hair thinning.
Hairless SKH1 mouse skin responded similarly , but without any induction of TNF-α mRNA or chondroitin sulfate.
Hairlines change shape with age , starting at birth.
Hair loss , or alopecia and hair graying are commonly associated with advancing age and are frequently a source for emotional distress and anxiety.
Hair regrowth started @number@ ± @number@ months after chemotherapy ceased and lasted for @number@ ± @number@ months.
Hair thickness changed little with age.
HA levels in skin decline with age resulting in decrease in skin moisture , which may contribute to loss of firmness.
Half of all tasks were perceived as less dentist-centered as a result of the intervention.
Half of LVOTO patients and no MVO patients showed high erythrocyte creatine levels.
Half of the cemented restorations were subjected to an artificial aging program ( n = @number@ ) .
Half of the ceramic-tooth assemblies were cemented with Panavia , the rest with Clearfil.
Half of the examined patients performed only physical exercises while the second half of the group participated in WBC before performing the same exercises.
Half of the films were presented without sound ( context-poor condition ) and the other half was presented with sound ( context-rich condition ) .
Half of the forehead in each patient was randomized to receive the treatment and the other half served as control.
Half of the incidental VTE occurred in the first 3-6 months of chemotherapy with a relatively higher incidence in gynecological and lung cancers.
Half of the participants completed these examinations under stereotype threat about their cognitive abilities.
Half of the participants found the game interesting.
Half of the participants had normal hearing and vision , @percent@ impaired hearing , @percent@ impaired vision , and @percent@ had dual-sensory impairment.
Half of the participants studied a target country alone and the other half studied a target country along with eight distractor countries.
Half of the patients had evidence of the full range of D-O-M delirium symptoms.
Half of the pictures had a human context , and the other half did not.
Half of the specimens of each subgroup were subjected to thermo-dynamic loading in a chewing simulator with @number@ cycles at 10kg load.
Half of the specimens were then loaded until failure without artificial aging ; the other half underwent artificial aging before assessment of the ultimate load.
Half of the words had a high NOF and the other half had a low NOF.
Half of the world's population , aged @number@ and older , suffers from OA.
Half of those with clinical frailty ( i.e. , Clinical Frailty Scale score ≥5 ) were younger than @number@ years old.
Half or more of hospitalised HZ patients have post-herpetic neuralgia , secondary infections , or inflammatory sequelae that are occasionally fatal.
Half the specimens in each group were intrinsically pigmented , and the other half remained unpigmented.
Half-times of emptying tended to be longer for women than for men ( not statistically significant ) .
Hallmarks of aged cells include compromised nuclear envelope integrity , impaired nucleocytoplasmic transport , and accumulation of DNA double-strand breaks.
Hallmarks of aging and carcinogenesis are changes in telomere length and telomerase activity.
Hallucinations , particularly well-formed visual hallucinations , favour DLB.
Hallux and toe flexor strength values were strongly correlated with the size of the intrinsic toe flexor muscles.
Hallux valgus ( HV ) related pain and disability remains a medical challenge to date.
Haloperidol is known to have high affinity interactions with the S1R , yet it was unable to facilitate BDNF release.
HAMR can identify these modifications transcriptome-wide with single nucleotide resolution , and also differentiate between different types of modifications to predict modification identity.
Hamster SCN contains less cholinergic neurons , whereas the mouse SCN is devoid of such cells.
Handbags are also significant to making personal or private space within care settings.
Handbags may also be adapted or discarded due to changing bodies , lifestyles and the progression of dementia.
Handgrip data were recorded as force-time curves , peak force , and explosive force parameters.
Handgrip strength can be used as a universal marker of ageing.
Handgrip strength , gait speed , leg weight bearing index , and nutritional intake improved after exercise training in patients both with and without sarcopenia.
Handgrip strength may not be an appropriate surrogate for lower body strength , power , or balance.
Handgrip strength was assessed using a Jamar hand dynamometer.
Handgrip strength was measured using the Jamar Dynamometer.
Handgrip strength was measured with a handgrip strength dynamometer.
Handgrip-strength was significantly correlated with forearm-ulna MT in both men and women.
Handheld technology or that integrated into housing can improve the standard of living , help elders improve their functioning , and even monitor medication.
Handrail use was associated throughout follow-up with a consistent pattern of negative demographic , functional and medical parameters.
Hand searches were conducted in selected journals and their supplements.
Hand searching through citations and references of relevant articles was also undertaken.
Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate.
HA ( @number@ ) -Col and CHA-Col composites with various ratios were prepared and examined.
Haplogroup H showed a @percent@ higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max.
Haplogroups K and T , which share a common maternal ancestor , are shown as protective in TBI.
Haplo-insufficiency of the bHLH ( basic helix-loop-helix ) transcription factor single-minded @number@ ( SIM1 ) causes severe obesity in mice and humans.
Haploinsufficiency was revealed by both quantitative real-time PCR of the gene and protein analyses.
Haplotype analyses showed the existence of only two common haplotypes , together comprising @percent@.
Haplotype analysis and conditional analyses provide no evidence of further independent endometrial cancer risk variants at this locus.
Haplotype analysis confirmed that the \ "GA \ " haplotype derived from single-nucleotide polymorphisms in rs67327804 and rs1060743 showed a @number@.4-fold increased risk of LOAD.
Haplotype analysis of PSEN2 and APOE genotyping were performed in @number@ Alzheimer's disease patients , as defined by clinical diagnosis and Aβ42 levels.
Haplotype analysis revealed a different haplotype from that of the original Spanish families.
Haplotype analysis revealed significant differences in haplotype frequency distribution between these groups.
Haplotype analysis suggests at least @number@ independent origins for mutated alleles that cause p.Pro285Leu.
Haplotypes including SNPs spanning the PON genes were generally more significant than haplotypes comprising SNPs from @number@ gene.
Haplotypes were constructed , and two-point LOD scores were calculated.
Happiness and sadness were key outcomes of good and poor quality of life , respectively.
Happiness decoding is the only ability that was found well-preserved with advancing age.
Happiness was defined as a dichotomous variable.
Happy , fearful and sad faces specifically activated the amygdala , whereas angry or disgusted faces had no effect on this brain region.
HAPR was defined as LTA-AA in the upper quartile of the enrolled population.
HAP spherules were also found outside the sub-RPE deposits , ready to bind proteins at the RPE / choroid interface.
Haptoglobin did not differ by frailty status ( p = @number@ ) .
Harmane concentration was assessed using high performance liquid chromatography.
Harman's free radical theory of aging posits that oxidized macromolecules accumulate with age to decrease function and shorten life-span.
Harmonicity provides an important cue for auditory scene analysis.
Harmonised individual participant data from all seven cohorts were analysed separately and alternatively for each anthropometric indicator using multivariable Cox proportional hazards models.
Harms , mortality , and cholecystectomy rates were evaluated.
Harnessing the beneficial properties of microglia cells by modulating their polarization states provides great potential for the treatment of Parkinson's disease ( PD ) .
HARP has moderate diagnostic accuracy ( @percent@ ) for downstream decreased scores in activities of daily living.
HARP scores were derived from a formula that summed scores assigned to age , activities of daily living , and mental state categories.
Harris-Benedict or WHO equations are potential alternatives if information on FFM is unavailable , although their accuracy on an individual level is limited.
Harvests yielded the same number of nucleated cells but increased numbers of CD34 + cells and CFU-GM compared with single aspirates.
HAS-1 has been previously associated with multiple diseases , and an enhancer was recently mapped and experimentally validated within the site.
HAS-2 is a previously uncharacterized site possessing genomic features suggestive of enhancer activity.
HAS-3 contains features associated with Polycomb repression.
has palpable nodules.
Has the considerable contribution of female writers to the debate played a role ?
HA treatment was shown to be safe.
have yet been reported in varicella-zoster virus ( VZV ; also known as human herpesvirus @number@ [ HHV-3 ] ) .
Having a chronic health condition was also a strong predictor of vaccine receipt.
Having a diagnosis of dementia was associated with a lower remission rate and less improvement in the MADRS score during the treatment.
Having a higher well-being polygenic score buffered against increased depressive symptoms following a spouse's death.
Having a history of prior military service significantly predicted lower depressive symptomatology and higher psychological HRQOL.
Having an older partner and depression showed stronger negative associations in the 1970s.
Having an older partner , diabetes mellitus , coronary heart disease , higher physical health-sum score , and depression were related to less sexual activity.
Having a partner mitigated the adverse effects of multimorbidity on role functioning , but only in individuals who shared a home with their partner.
Having a permeability coefficient of @number@ × 10 ( @number@ ) cm s ( @number@ ) , it was classified as discrete BBB-permeable compound.
Having been advised to communicate wishes was a strong predictor of the likelihood of having done so.
Having children contributes to the well-being of older men with a partner.
Having concomitant surgery ( OR @number@ @percent@ CI @number@ @date@ ) was predictive of subjective failure only rather than objective failure.
Having culturally and linguistically competent research staff with excellent interpersonal skills facilitated implementation.
Having depressive symptoms was positively associated with the use of inpatient services , outpatient physician services , and public health centers.
Having diabetes was associated with @percent@ lower chance of improvement in women.
Having ever committed a violent offense and having received mental health services ( in and out patient ) are statistically associated with self-reported stress.
Having examined qualitative and quantitative data , we suggest that any community can foster changes to improve the health and well-being of its aging population.
Having experienced previous episode ( s ) of depression was associated with a lower remission rate.
Having incurable cancer often implies suffering.
Having introduced the epidemiologic , diagnostic data and forms of palliative therapies he concentrates on the hitherto unsolved problems of patients and caregivers.
Having lifetime prevalence of depression was defined as having a score ≥5 on the Geriatric Depression Scale-15 or a history of depression.
Having MetS , especially during middle-age , increases the risk for dementia in later life.
Having more Geographically Distant Male Youth in one's network was associated with health limitations , whereas more Close Family was associated with no health limitations.
Having more kits available worldwide by different companies could help bring the technology to different forensic laboratories and the justice system as a whole.
Having poor health substantially increases the likelihood of entering retirement , by up to @number@ percentage points.
Having positive attitudes to aging may contribute to healthier mental and physical outcomes in older adults.
HA was never posterior to the GL.
Hayflick ( PLoS Genet 3 ( @number@ ) : 2351-2354 , @number@ ) described six universal characteristics of aging that focus upon post-reproductive molecular entropy.
Hazard estimates were compared across both samples to cross-validate the results.
Hazardous anterior balance loss due to tripping can be attributed to the mid-swing phase event , minimum foot clearance ( MFC ) .
Hazardous organic wastes from industrial , military , and commercial activities represent one of the greatest challenges to human beings.
Hazard ratios and @percent@ CIs for cataract incidence were estimated with a multivariable Cox proportional hazards model.
Hazard ratios and @percent@ confidence intervals were computed from Cox proportional hazards regression models.
Hazard ratios for incident hypertension according to alcohol consumption were estimated using a Cox proportional hazards model adjusted for possible confounding variables.
Hazard ratios ( HR ) for incident diabetes were calculated using Cox proportional hazard models , adjusting for relevant confounders.
Hazard ratios ( HR ) for mortality were estimated in multivariate analyses with follow-up ending in @number@
Hazard ratios ( HRs ) and @percent@ CIs were estimated by Cox proportional hazards regression adjusted for demographics and diabetes-related risk factors.
Hazard ratios ( HRs ) and @percent@ confidence intervals ( CIs ) were estimated by Cox proportional hazards regression.
Hazard ratios ( HRs ) for CR were @number@ ( @percent@ CI @number@.54-1.58 ) for all-cause and @number@ ( @number@.48-2.65 ) for cardiovascular mortality.
Hazard ratios ( HRs ) were calculated during a median follow-up of @number@ years.
Hazard ratios ( HRs ) were estimated using Cox proportional hazards adjusted for covariates.
Hazard ratios ( HR ) with their @percent@ confidence intervals ( @percent@ CI ) were reported.
Hazard ratios of repeat self-harm and suicide were estimated by Cox proportional hazard models.
Hazard ratios were estimated by Cox regression , with adjustment for age and education ( further adjustment did not materially change the associations ) .
Hazard ratios were estimated with weighted Cox regression models using Barlow weights to account for the case-cohort design.
HbA1c at baseline predicted a target setting such that higher the HbA1c , more aggressive was the target ( P < 0.001 ) .
HbA1c , dyslipidemia , hypertension , PD and duration of the procedure were predictive of infection complications ( p < @number@ ) .
HbA ( 1c ) increased in both genders with age ( p < 0.001 ) .
HbA1c is negligible negatively related to increased PP levels ( multiple linear regression ) .
HbA1c is not sufficient for hypoglycemia risk detection ; capillary blood glucose monitoring is warranted for nursing homes residents with diabetes.
HbA1c is unsuitable for diagnosing diabetes in elderly individuals because of their physiologically decreased RBC count.
HbA1c showed a carryover effect and its reduction was similar with detemir and glargine in the first arm.
HbA1c showed a nonlinear association with cognitive functioning , with a peak of cognitive performance in the central quintile of HbA1c.
HbA1c was adjusted for age , sex , centers , @number@ principal components , without and with BMI.
HbA1c was higher ( @percent@ ) in [ SLF & / or SLM ] ( p @number@ ) .
HbA ( 1c ) was measured on a National Glycohemoglobin Standardization Program-certified Bio-Rad D-10 system and the data were available for @number@ subjects.
HbA₁ ( c ) , duration of DM and microvascular complications of DM were reviewed.
Hb concentration was measured on a daily basis before the surgery.
HBF in normal volunteers averaged @number@ ± @number@ mL / ( @number@ g min ) .
HB-treated rats showed a minor degree of inflammation , both at cytokine and TEM analyses.
HBx and ROS maintained a positive regulatory loop , which aggravated carcinogenesis.
HCAR1 could serve to ameliorate these conditions and might also act through downstream mechanisms other than cAMP.
HCAR1 may contribute to optimizing the cAMP concentration.
HCC developed in @number@ patients : one with SVR versus @number@ with non-SVR ( P = @number@ ) .
HCC showed significant moderating on the relationship between perceived stress and job well-being in expected directions.
HCC was assessed by alfa-fetoprotein and ultrasound every @number@ months.
HCE exercise also resulted in greater positive change in exercise enjoyment ( p = @number@ ) , which was mediated by weight change.
HCH6-1 inhibited superoxide anion generation , elastase release , and chemotaxis in human neutrophils specifically activated by ( fMLF ) , an FPR1 agonist.
HCH6-1 produced right shifts in the concentration-response curves of fMLF , suggesting that HCH6-1 was a competitive antagonist of FPR1.
HCMV genome contains a number of accessory genes.
HCO3 was determined using the Henderson-Hasselbalch equation.
HCPs of residents in hospice reported fewer unmet needs in all domains during the last @number@ days of the residents ' life.
HC-related parameters showed significant age dependency.
HCT1026 provides a novel promising approach towards the development of effective pharmacological neuroprotective strategies against PD.
HCT increased caspase-3 and caspase-8 mRNA , protein levels , and caspase activities in a concentration- and time-dependent manner.
HCT induced MAPK phosphorylation in a time-dependent fashion.
HCV impairs the Nrf2 / ARE-dependent induction of ROS-detoxifying enzymes by a so far unprecedented mechanism.
HCV infection was negatively associated with hypercholesterolaemia.
HCV peptide-stimulated CD4 + and CD8 + T cells of chronic HCV ( CHC ) patients showed significant increase of CTLA-4.
HCW involvement is required in program implementation in order to avoid rejection of top-down information.
Hcy-associated differentially methylated positions and regions were identified using meta-analysis.
Hcy is sensed by a constitutive protein complex composed of leucyl-tRNA-synthetase and folliculin , which regulates mTOR tethering to lysosomal membranes.
Hcy levels significantly affected suboptimal response to ASA , but not to ADP-mediated aggregation.
HCys values were also higher in both age groups when at least two oxidant risks were present.
HDAC1 and @number@ were decreased at this promoter during cell cycle progression.
HDAC expression was down-regulated at multiple levels.
HDACs activities in SH-SY5Y cells were inhibited by gamma-hydroxybutyrate which did not affect amyloid peptide precursor intracellular domain.
HDFs treated with DA-CM exhibited higher collagen types I and III secretion and significantly lower MMP-1 and MMP-3 secretion.
HD is a devastating autosomal dominant disease with no disease-modifying treatments.
HDL2 and HDL3 from the AF group showed decreased antioxidant ability and an approximately @percent@ lower expression of apoA-I compared to the control group.
HDL cholesterol was increased in all the hormone treated groups except the estrous cycle-mimicking group.
HDL concentration in the plasma from AD Plus patients was significantly lower compared to AD or control subject HDL levels.
HDL concentration is lower in AD Plus patients ' plasma and thus capacity for RCT is compromised.
HDL-C was a major determinant of HDL size and volume , which were differently modulated in females and in males.
HDL efflux capacity was directly associated with large ( β = @number@ Matrix Gla protein ( MGP ) is a potent inhibitor of vascular calcification.
HDL functionality is regulated by various proteins and lipids making up HDL particles.
HDL subclasses differ in physical-chemical properties , protein and lipid composition , metabolism , physiological functions and pathophysiological significance.
HD patients eventually manifest parkinsonian-like symptoms , which underlie defects in the dopaminergic system.
HD patients exhibit a high incidence of cardiovascular events , presumably as a result of accumulation of toxic amyloid-like inclusions.
HDPCs were serially subcultured until spontaneously arrested for in vitro aging , and the replication deficiency adenovirus was introduced for PPARγ overexpression.
Headache frequency ( per month ) , severity , and duration ( hours ) were the primary measurement parameters employed for data analysis.
Headache prevalence and frequency were reduced.
Headache was present in nearly all documented cases.
Head circumferences were plotted from the charts and z-scores were calculated and compared with that of family members.
Head-fixed young , middle-aged , and elderly listeners localized band-passed targets using visually guided manual laser pointing in a darkened room.
Head haematomas and soft tissues contusions were the most common consequences of falls.
Head immobilization during blast exposure prevented blast-induced learning and memory deficits.
Head injury was retrospectively asked , and genotyping was performed mainly as part of a previous GWAS.
Head magnetic resonance imaging revealed severe frontotemporal lobe atrophy with severe lateral ventricular dilatation and frontal white matter degeneration.
Head motion reduces data quality of neuroimaging data.
Head pitch increased , whereas head-roll velocity decreased in narrow-base walking.
Head roll significantly decreased with GVS regardless of age.
Head-roll velocity decreased in the blurred-vision condition and marginally increased with GVS in older but not in young participants.
Head trauma was defined as a self-reported brain injury with at least momentary loss of consciousness or memory.
Head trauma was the most common cause in mortality.
Head tremor is not reported to occur in patients with enhanced physiological tremor.
Head-turn gait speed best predicted BTL.
Healing of the injured endothelial monolayer is impaired in senescent cells.
He also believed that the elderly should consider special schemes in order to maintain their health.
Health and cognitive benefits to playing walking football were not found.
Health and functional limitations posed the greatest challenge to socialization relative to characteristics of the facility itself.
Health and mental health professionals can work toward reducing mental health disparities by accounting for older Asian Americans ' help-seeking patterns when designing evidence-based interventions.
Health and psychological factors accounted for @percent@ of dizziness.
Health and social care settings worldwide need to sustainably improve the quality of relationships across communities or ' whole systems'.
Health and social factors that shape eating behaviours place older people at increased nutrition risk.
Health and well-being of younger allotment gardeners did not differ from younger neighbors.
Health and wellbeing were perceived as multidimensional concepts by participants , which did not always match available services primarily developed for non-Indigenous populations.
Health and work characteristics positively influenced work ability.
Health anxiety disorders ( e.g. , hypochondriasis ) are prevalent but understudied in older adults.
Health behaviors and obesity did not mediate the examined associations.
Health behaviors of smoking cessation , oral hygiene , and exercise promote pulmonary health even in older adults.
Health behaviors reduce the hazard ratio by @percent@ for all nonsuicide mortality , @percent@ for cardiovascular disease mortality , and @percent@ for cancer mortality.
Health behaviours considered were self-reported cigarette smoking , physical activity level , and frequency of alcohol consumption.
Health care and education are free.
Healthcare costs for treating fractures and subsequent complications will increase to $ 25 billion by @number@
Health care costs have increased due to population ageing.
Healthcare costs included nine conditions , and mortality was estimated for four perinatal and three adult conditions.
Health care decision makers are required to make planning decisions over a medium to long term planning horizon.
Health care disparities are inequities occurring during the provision of and in access to health care that are experienced by socially disadvantaged populations.
Health care expenditures rose from @percent@ of the GDP in @number@ to @percent@ in @number@
Health care expenses in the United States are increasing inexorably.
Healthcare for MCC was experienced as piecemeal and fragmented with little focus on the person and family as a whole.
Health care interventions that use quality of life or health scores often provide data which are skewed and bounded.
Health care in the United States includes a vast array of complex interrelationships among those who receive , provide , and finance care.
Healthcare is also a source of a million jobs.
Healthcare organizations are challenged with constrained resources and increasing service demands by an aging population with complex care needs.
Health care practitioners must assess risks vs benefits of therapeutic diets , especially for older adults.
Health care practitioners often lack the expertise or time to adequately assess behavioral symptoms or counsel caregivers about interventions.
Health care professionals and patients may lack a common \ "first language. \ "
Health care professionals are suggested to be aware of the depressive symptoms of U.S. Chinese older adults with high filial expectations and low receipt.
Health care professionals caring for older emergency department ( ED ) patients miss delirium in approximately @percent@ of cases.
Health care professionals encounter elder abuse in the community and in medical offices , emergency rooms , hospitals , and long-term care facilities.
Healthcare professionals have vital roles in supporting them to continue living in the community.
Health care professionals must understand the many factors involved in the anorexia of aging to help older adults prevent unintentional weight loss.
Health care professionals need to be aware of the different effects of communication difficulty on the pain experiences of older adults.
Healthcare professionals play a crucial role in the management of factors associated with poor compliance and persistence with osteoporosis therapies.
Healthcare professionals should educate and encourage influenza vaccination among people with diabetes.
Healthcare professionals should provide and demonstrate the importance of assistive devices to ensure management of fatigue in persons living with late effects of polio.
Healthcare professionals were trusted sources of information but direct payment advisers appeared less so.
Health care providers can educate women about proven best practices and how to evaluate products ' claims of benefits.
Health care providers can further reduce sickness absence and health care costs by providing the proper treatment and by reducing waiting times.
Health care providers may consider supplementing traditional medical approaches with a more contextually sensitive recognition of rural elders ' desired health goals and outcomes.
Health care providers must be aware of factors that may impact sexual health in older adults.
Healthcare providers represented various disciplines and settings.
Healthcare providers should consider carefully the risks and benefits of nonsteroidal anti-inflammatory drugs , opioids , and adjuvants before initiating an analgesic trial.
Healthcare reform has led to an increased emphasis on interprofessional healthcare models for older adults.
Healthcare research has identified scientific methods helpful in providing sound evidence for decision makers in health policy.
Health care resource use and costs were estimated from enrollment through one year follow-up.
Health care staff indicated that the protocol resulted in more careful evaluation of residents ' pain and greater appropriateness of prescriptions including reductions in polypharmacy.
Health care stakeholders wish older adults to take more control of their health to delay the onset of age-related disabilities and chronic diseases.
Health care systems in Western societies are faced with two major challenges : aging populations and the growing burden of chronic conditions.
Health care transitions are often dangerous for older patients.
Healthcare utilisation decreases with age , and in old age , fewer people with ID use healthcare compared with the general population.
Healthcare utilization data will be available for a subsample of participants.
Healthcare workers will be individually trained how to assess , intervene and evaluate acute and chronic pain.
Health challenges associated with ageing , changing social networks and limited public health infrastructure are issues faced by the elderly and caregivers.
Health congruence and functional well-being of @number@ older adults were assessed via two interviews conducted @number@ years apart.
Health consequences of rising obesity rates in the United States underscore that efforts to reduce obesity may be beneficial to maternal and perinatal health.
Health disparities among Native Hawaiian kupuna ( elders ) continues to be a major health issue.
Health disparities among sexual minority adults ages @number@ and older have been documented.
Health disparities exist among sexual minority older adults.
Health dynamic projections suggest the effects of health care investment are large and growth stimulating.
Health education should be carried out according to the related characteristics of age and sex.
Health effects of in utero exposure to ionizing radiation , especially among adults , are still unclear.
Health-enabling technologies for pervasive healthcare and sensor-enhanced health information systems offer new opportunities for care.
HealtheSteps™ participants are provided with in-person lifestyle coaching and access to eHealth technologies delivered in community-based primary care clinics and health care organizations.
Health examination data from @number@ to @number@ were provided by the Taipei Databank for Public Health Analysis.
Health expenditures did not correlate with life expectancy and mortality , and health expenditures did not mediate links between inequality and health.
Healthier low-GI carbohydrate foods may prevent adiposity-related cancers among women , but these findings require confirmation in a larger sample.
Health indicators are not dependent on enterprise structures , but on age and gender - on age partly non-linearly.
Health indicators were significant and in the expected direction ( p < @number@ ) .
Health issues that may impede both gynecologic care and self-sufficiency include sensory deficits , physical disability , and cognitive impairment.
Health knowledge gained through research that ignores the socio-political context may be limited in terms of generalization.
Health knowledge ( β = @number@ p < @number@ ) emerged as a positive predictor of PHR collecting skills.
Health lifestyles are collective patterns of health risk behaviour that develop within a social habitus.
Health literacy and numeracy were assessed.
Health literacy attenuated the relationship between black race and decline in physical function by @percent@.
Health literacy did not add to the predictive power of our model ( P values range .43-.92 ) .
Health literacy had a negative relationship with self-care management ( Rs = @number@ P = @number@ ) .
Health literacy is known to affect vulnerable communities such as persons living with HIV / AIDS.
Health literacy , participation in the national CRC screening programme , and covariates were interview-assessed in @date@ .
Health literacy was independently associated with knowledge ( P < @number@ ) .
Health literacy was measured at baseline ( 2004-2005 ) and at follow-up ( 2010-2011 ) using a reading comprehension test of a fictitious medicine label.
Health literacy was not related to self-care.
Health literacy was positively associated with education , marriage status , and number of people living with.
Health literary was not associated with self-reported health status or quality of life.
Health management programs should provide holistic approaches to maximize health outcomes and to promote successful aging.
Health optimism and pessimism have different psychosocial contributors and health correlates , validating the health congruence approach to later life well-being , health and survival.
Health outcomes included physical function , self-rated health , cognitive function , and depressive symptoms.
Health outcomes included self-reported health ( SRH ) , physical inactivity , and hypertension.
Health perception mediated attitudes toward personal aging.
Health phenotype , circulating cytokines and biomarkers of microbial translocation ( MT ) were measured ( n = 26-44 ) .
Health policy analysts are encouraged to target the dissemination of productivity enhancing interventions to employers with high losses rather than all employers.
Health practitioners must be able to recognize limited health literacy to ensure that clinical demands match the literacy skills of diverse patients.
Health problems and functional limitations hampered food management , and some families had inveterate eating habits.
Health problems become socio / economic threats.
Health problems tend to be frequent and increasing with age within this cohort.
Health problems were modeled as a latent factor of functional disability , the number of chronic diseases , and self-rated health.
Health professionals caring for older people with dementia are central to the safe management of this practice.
Health professionals should encourage activities that preserve muscle strength , thereby preventing the incidence of diabetes in older Mexican Americans.
Health professionals supervising students reported more frequent use of appraise research reports than the non-supervising group.
Health promoters and investigators must adopt flexibility and participatory mentality to develop cost-effective interventions.
Health promoters can use the proposed framework to promote PA and decrease falls risk.
Health promotion for older persons who have experienced migration is thus an area of public health importance.
Health promotion initiatives meant to combat depression may wish to consider gender differences in the design and implementation of neighbourhood or peer-based programs.
Health promotion through physical activity is being increasingly emphasized.
Health promotion to improve QoL should focus on prevention of obesity and central fat accumulation.
Health-related constraints and disabilities as well as lower control beliefs and higher loneliness were each associated with lower self-esteem late in life.
Health-related effects from extreme heat are more common in elderly populations.
Health-related factors ( pain , comorbidities , polypharmacy ) as well as age and gender were also measured.
Health-related factors were in general stronger associated with sickness absence than with low performance at work.
Health-related problems are known to cause lower QOL.
Health-related quality of life ( HRQoL ) and oral health-related quality of life ( OHRQoL ) were measured with the EQ-5D and OHIP-14 questionnaires.
Health-related quality of life ( HRQoL ) was assessed with the Medical Outcomes Study Short Form-12 ( SF-12 ) .
Health-related quality of life was assessed by short-form @number@ questionnaires.
Health-related quality of life was assessed using the Short Form @number@ questionnaire.
Health-related quality of life was assessed with the Health Utilities Index Mark @number@ ( HUI3 ) .
Health-related variables controlled for socio-demographic background were the independent variables.
Health represents the organisms ' ability to sustain homeostasis and return to it after action of external disturbances.
Health research on an increasingly aging population calls for careful consideration of aging-associated phenomena , such as dementia.
Health resource consumption for subdural hematoma is increasing without clear evidence that management practices are leading to improved outcomes.
Health-risk communications frequently target self-efficacy in order to encourage adaptive responses.
Health risk factors , except hypertension , did not differ between groups.
Health risks associated with subclinical hypothyroidism in older adults are unclear.
Health selection is likely to influence nondrinking across the life course.
Health services use and deaths have been obtained by record linkage and confirmed , where necessary , by telephone interview.
Health service use was measured by a questionnaire for a 3-month period.
Health-spending increases were associated with greater life expectancy improvements for men than for women in nearly every OECD country.
Health spending is also increased unnecessarily by bureaucratisation of healthcare spending and the transfer of professionals to posts for which they are not qualified.
Health status across six domains ( cognition , interpersonal activities , sleep / energy , self-care , mobility , pain / discomfort ) was assessed.
Health status and depressive symptoms were compared between patients with and without cognitive impairment.
Health status included comorbidities , activities of daily living ( ADL ) , instrumental ADL , and depressed mood.
Health status is a significant predictor of self-reported stress in univariate and multivariate analyses.
Health status was assessed using measures of vigilance , depression , perceived stress , coronary artery disease , diabetes , blood pressure , and inflammation.
Health status was lower for survivors , and was significantly different by racial / ethnic group.
Health status was related to men's evaluation of the experience.
Health supporting amenities were mapped , focus groups were conducted , and demographic information was obtained.
Health system and hospital reforms have led to important and on-going legislative , structural and organizational changes.
Health system costs over the same time period are estimated to increase from $ AU355 million to $ AU784 million.
Health systems , as well as individual practitioners , are only just becoming aware of the extent of this problem.
Health systems will have to rapidly change practice to manage the number of people dying in the coming years , many with complex multimorbid conditions.
Health systems worldwide are grappling with the need to control costs to maintain system viability.
Health teams need to interfere in this concept , providing care to older people during their recovery and until the end of life.
Health was evaluated by self-report instruments.
Healthy adult men ( N = @number@ ) and women ( N = @number@ ) participated in the study.
Healthy aged tissue showed similar regional elasticity but with both unimodal and bimodal distributions that included higher elastic moduli.
Healthy aged women presented dilated capillaries with sustained perfusion and endothelial dysfunction with preserved vascular smooth muscle reactivity.
Healthy aging can delay onset of all age-related diseases.
Healthy aging depends on a combination of individual genetic factors and external environmental factors.
Healthy aging has been associated with decreased specialization in brain function.
Healthy aging is accompanied by a decrease in cognitive and motor capacities.
Healthy aging is accompanied by neurobiological changes that affect the brain's functional organization and the individual's cognitive abilities.
Healthy aging is associated with a progressive decline across a range of cognitive functions.
Healthy aging is associated with cognitive declines typically accompanied by increased task-related brain activity in comparison to younger counterparts.
Healthy aging is associated with declines in episodic memory.
Healthy aging is usually marked by low probability of age related disorders.
Healthy aging requires an optimal balance between pro-inflammatory and anti-inflammatory immune responses.
Healthy Aβ + individuals acknowledged progressive memory change , suggesting they are aware of memory changes not yet detectable via neuropsychological measures.
Healthy brain aging is characterized by neuronal loss and decline of cognitive function.
Healthy brain development involves changes in brain structure and function that are believed to support cognitive maturation.
Healthy , but also diseased , elderly people are increasing.
Healthy cartilage is exposed by hydrostatic pressure and tensile strain , when cartilage degeneration develops , abnormal cartilage is exposed by shear stress.
' Healthy Class ' ( @percent@ ) : metformin reduced likelihoods of all ARCs ( from @percent@ in dementia to @percent@ in CVD ) .
Healthy community-dwelling volunteers ( @number@ young and @number@ elderly subjects ) were studied with the 20-item Toronto Alexithymia Scale.
Healthy-controls reached a peak compensation of @number@ ± @number@ cents , and demonstrated a sustained compensation at @number@ ± @number@ cents.
Healthy diet and physical exercise are very important for the prevention and treatment of both entities.
Healthy , elderly individuals of Chinese ethnical background were recruited under the aegis of SLAS-II.
Healthy elderly participants performed accurate isometric force production tasks in five directions by individual fingers and by all four fingers acting together.
Healthy elderly subjects ( n = @number@ ) divided into three different age groups were assessed using a semantic memory test of famous people.
Healthy elders did not demonstrate any significant connectivity changes.
Healthy erupted third molars were extracted from individuals from two Spanish populations , aged 20-70.
Healthy food availability was determined in thirty-four census tracts of varying racial and SES composition using the Nutrition Environment Measures Survey-Stores in @number@
Healthy habits may slow the process of health deterioration , but research investigating relationships between health and various health behaviors is lacking.
Healthy individuals showed a broad range in average telomere length in granulocytes and lymphocytes at any given age.
Healthy life expectancy is a composite measure of length and quality of life and an important indicator of health in aging populations.
Healthy lifestyle in elderly seemed partially account for the declined BMI.
Healthy longevity has been an unremitting pursuit of human , but its genetic and the environment causes are still unclear.
Healthy longevity is associated with environmental conditions , but its significance is still unclear.
Healthy men ( n = @number@ ) and women ( n = @number@ ) aged 40-79 years participated in the present study.
Healthy neurons may also chronically acquire iron from the extracellular space as another principle mechanism for oxidative stress-mediated damage.
Healthy old and young adults ( n = @number@ each ) participated in this study.
Healthy older participants and Alzheimer's disease ( AD ) patients show better memory for faces with positive expressions.
Healthy older people showed low serum levels of CRP and pro-inflammatory cytokines , but higher than in younger population.
Healthy older women were assigned to low-volume ( LV ) or high-volume ( HV ) training groups.
Healthy ovaries from @number@ organ donor cadavers served as controls.
Healthy participants were presented with the eye-gaze shift ( EG ) and self-propelling motion ( SP ) under both implicit and explicit task conditions.
Healthy , right-handed participant groups were comprised of @number@ sedentary older adults , @number@ physically active older adults , and @number@ young adults.
Healthy subjects @number@ to @number@ years old received the 2010-2011 trivalent inactivated influenza vaccine.
Healthy survivorship or other TL-damaging factors such as somatic health problems seem to dominate a potential effect of psychosocial stress on TL in older adults.
Healthy volunteers were supplemented daily with @number@ g of strawberries for @number@ month.
Healthy walking is characterized by pronounced arm swing and axial rotation.
Healthy younger and older adults were tested on a simple go / nogo task with visually presented numbers.
Healthy young participants learned two routes to a @percent@ criterion.
He and members of his family had a history of recurrent pneumothorax during the last few decades.
Hearing ability was measured by a digit triplet speech-in-noise test ( SNT ) yielding a speech reception threshold in noise ( SRTn ) .
Hearing aid owners were more likely to report adequate hearing aid self-efficacy if they had had a positive hearing aid experience and no visual disability.
Hearing aid troubleshooting tips can help you overcome @number@ common patient objections.
Hearing and vision loss typically increase with older age.
Hearing disorders become an increasingly important issue that influences quality of life and many other economic factors.
Hearing impairment affects a patient's learning.
Hearing impairment ( HI ) is prevalent , is modifiable , and has been associated with cognitive decline.
Hearing impairment is on the rise with the aging population.
Hearing impairment seems to be the main factor underlying speech perception problems in background noises that cause energetic masking.
Hearing impairment was defined as a pure-tone average ( @number@ @number@ @number@ and @number@ kHz ) greater than @number@ db hearing level in either ear.
Hearing loss in older adults , in fact , is associated independently with poorer cognitive functioning , incident dementia , and falls.
Hearing loss is common in all age groups , even in young adults and adolescents.
Hearing loss is the most common sensory deficit in the elderly , and is becoming a severe social and health problem.
Hearing loss is usually measured as an elevation of a person's hearing thresholds , expressed in decibel ( dB ) .
Hearing loss is widespread and persistent because mature mammalian auditory hair cells ( HCs ) are nonregenerative.
Hearing loss , presbycusis , is one of the most common sensory declines in the ageing population.
Hearing loss was depicted as comical , embarrassing , lonely , and threatening to one's work.
Hearing loss was determined with screening audiometry ( n = @number@ ) .
Hearing loss was greatest at high frequencies.
Hearing loss was not significantly associated with social isolation in other age and gender groups.
Hearing status has often been a confounding factor in older individuals.
Hearing thresholds for pure tone frequencies of @number@.5-4 kHz were averaged to obtain a pure tone average in the better-hearing ear.
Hearing was measured by self-report and by a speech-in-noise test.
Hearing was measured with pure-tone audiometry.
Hearing was not associated with use of the other health services studied , except presenting for a hearing test.
Heart attack knowledge , self-efficacy for recognizing and responding to heart attack symptoms , and perceived risk for a future heart attack were measured.
Heart attack , massive stroke , or intracranial bleed were ruled out , and an electroencephalogram showed no epileptiform activity.
Heart disease , cancer , and other chronic illnesses are either more common or more severe in aging patients.
Heart disease , certain cancers and obesity persist at epidemic rates in the US and Western Europe.
Heart disease remains the number one cause of death in developed countries.
Heart disease was the most costly condition for both women ( $ 701.7 million ) and men ( $ 180.6 million ) .
Heart failure can be regarded as a systemic syndrome of aging-related phenotypes.
Heart failure exacerbations and hospitalizations likely accelerate the cycle of frailty.
Heart failure ( HF ) increases significantly in relation to advancing age , yet management for HF in very old adults remains ambiguous.
Heart failure ( HF ) in the elderly is a major public health problem , and its prevalence is rising.
Heart failure ( HF ) is a common and potentially deadly condition , which frequently develops as a consequence of various diseases of the heart.
Heart failure ( HF ) is a common clinical syndrome with frequent exacerbations requiring hospitalization.
Heart failure ( HF ) is a common problem in older adults.
Heart failure ( HF ) remains an important heath care problem in the United States.
Heart failure in Drosophila , as in humans , can be classified into dilated cardiomyopathies and hypertrophic cardiomyopathies.
Heart failure is a chronic progressive disorder in which frequent and recurrent hospitalizations are associated with high mortality and morbidity.
Heart failure is a common and disabling condition with morbidity and mortality that increase dramatically with advancing age.
Heart failure is a common pathology sometimes considered as a \ "new epidemic \ ".
Heart failure is a complex syndrome with a host of pathophysiological mechanisms in action.
Heart failure is a disease of poor prognosis marked by frequent hospitalizations , premature death , and impaired quality of life.
Heart failure is a global disease with increasing prevalence due to an aging worldwide population with increasing co-morbidities.
Heart failure is a leading cause of death in industrialized nations especially in an aging population.
Heart failure is an increasingly common disease associated with significant morbidity and mortality in the aging population.
Heart failure places an enormous burden on health and economic systems worldwide.
Heart failure related admissions , clinic visits , cardiovascular drugs , laboratory tests and diagnostic tests were documented.
Heart failure should be confirmed by the patient's cardiologist according to the European Society of Cardiology guidelines criteria.
Heart failure spending varied widely between high-income and middle and low-income countries.
Heart failure was superior to multimorbidity patterns in explaining emergency-room visits.
Heart failure with preserved ejection fraction ( HFpEF ) is the most common form of heart failure ( HF ) in older adults.
Heart lesions were classified as \ "severe \ " and \ "other. \ "
Heart rate and behavioral measures ( number of mistakes , reaction time ) were also investigated.
Heart rate , blood pressure and BL were obtained during each increment of exercise intensity.
Heart rate changes during a sevoflurane induction appear to be age-dependent.
Heart rate did not change significantly during propofol administration between groups or within groups.
Heart rate variability ( HRV ) analysis was performed.
Heart rate variability ( HRV ) has been increasingly used to monitor team sports athletes.
Heart rate variability ( HRV ) is widely used to evaluate autonomic nervous activity in humans.
Heart rate variability ( HRV ) may be used to assess autonomic imbalances , diseases and mortality.
Hearts of transgenic mice displayed increased mitochondrial energy metabolism and induced stress defense mechanisms , while overall oxidative stress was decreased.
Heart weights of the DEX fetuses also tended to be smaller at E14.5 , but not different at E17.5.
Heat is the most abundant byproduct of cellular metabolism.
Heat shock factor @number@ ( HSF1 ) is an evolutionarily highly conserved transcription factor that coordinates stress-induced transcription and directs versatile physiological processes in eukaryotes.
Heat shock factor @number@ ( HSF1 ) is critical for defending cells from both acute and chronic stresses.
Heat shock increases skin temperature during sun exposure and some evidence indicates that it may be involved in skin aging.
Heat shock induced the downregulation of Nrf2 in both the cytosol and nucleus and reduced the expression of HO-1 , GSH , and NQO1.
Heat shock protein inducers share metabolic pathways associated with exercise with activation of AMPK , PGC1-a , and sirtuins.
Heat shock protein @number@ ( HSP70 ) protects cells from accumulating damaged proteins and age-related functional decline.
Heat shock proteins ( Hsps ) are expressed in mammalian embryonic , adult and aging lens , cornea and retina.
Heat stress had no effect ( P ≥ @number@ ) on RVP or CRT accuracy in either group.
Heat waves result in significant excess mortality , particularly amongst elderly people.
Heavier patients have an increased aorta-sacral promontory distance.
Heavy / binge drinking was defined as the consumption of 4 + drinks for men and 3 + drinks for women per drinking day.
Heavy drinking in adults ages @number@ and over is strongly correlated with depression , anxiety , decreased social support , and poor health.
Heavy metals ( Pb , Cd , Hg and W ) may contribute to a lower concentration of DHEAS.
Heavy resistance exercise bouts ( @number@ × @number@ RM leg presses ) were performed before and after the training period.
He belongs to the experts identifying the Alzheimer diseases as a forced aging process.
Heberden nodes develop in the distal interphalangeal joints and typically present as a deformed and enlarged joint and can cause pain.
He establishes that the occurrence of degenerative processes connecting the aging must be limited by preventive interventions far more efficient than the present possibilities.
He first experienced insidious-onset hand muscle weakness and atrophy at the age of @number@
He had received adjuvant radiotherapy ( @number@ times ) and was transferred to the plastic surgery department for dealing with oronasal fistula.
He had undergone a cardiological investigation some months before his death , enabling him to participate in competitive sports.
HE has been used in traditional folk medicine and medicinal cuisine in China , Korea and Japan.
Height adjustment of BMD Z score was performed using height-for-age Z score.
Height and weight at midlife ( mean age @number@ ) were available in the Registry.
Height and weight were measured at clinic visits.
Height and weight were measured , BMI was calculated.
Height and weight were measured in all subjects.
Height , body weight , and BMI did not change.
Height correlated with neck-shaft angle , hip-knee shift , femoral and tibial torsion only.
Height increased with age only at L4 and L5.
Height is a highly heritable , classic polygenic trait with approximately @number@ common associated variants identified through genome-wide association studies so far.
Height loss was also associated with a low SES in men and women.
Height loss was calculated as the difference between the subject's self-reported maximum adult height and their measured current height.
Heights were adjusted for estimated loss with age using two protocols ; height at @number@ years of age was also estimated.
Height was measured with a digital height measurer.
Height was shortest at L5 ( @number@.2±2.7 mm ) .
Height was the most consistent correlate of functional performance in children , while lower limb muscle strength was a major determinant in adolescents and adults.
Height , weight and body fat percentage were measured.
Height , weight and measures of the five nutritional risk factors were collected at interviews @number@ months apart.
Height , weight , and refraction were recorded.
Heire , effect of carnosine in cell cultures was studied.
HEI score is a good assessment for diet quality , but further investigation of influence on other sociodemographic and health characteristics is required.
HeLa cells and Mock clones , which express endogenous wild-type CDC42 and show normal activity , are more resistant to UV radiation.
Hela cells with stable expression of the MT-ATP6 gene with B5-defining variant m.8584G > A also showed a significantly decreased mitochondrial function.
Helical conformation is observed from residue K3-M11.
Helicases are molecular motors that convert the energy of nucleoside triphosphate hydrolysis to unwinding of structured polynucleic acids.
Helicases must unwind DNA at the right place and time to maintain genomic integrity or gene expression.
Helicobacter pylori is one of the most common pathogens affecting humankind , infecting approximately @percent@ of the world's population.
HELP can assist in monitoring lifestyle risk factors and measuring the outcome of services aimed at promoting healthy lifestyles among older adults.
' Help-seeking behavior for sleep problems ' and ' diagnosis with sleep disorders ' were defined as yes / no questions.
Help seeking was delayed up to four years , even with significant dementia symptoms.
Hematocrit and prostate-specific antigen levels increased more in testosterone group.
Hematocrit levels increased but remained within safe margins.
Hematological deficiencies increase with aging leading to anemias , reduced hematopoietic stress responses and myelodysplasias.
Hematological malignancies are typical diseases of the elderly.
Hematological parameters were assessed using the Sysmex xs-800i hematology analyzer.
Hematologic malignancies comprise a set of prevalent yet clinically diverse diseases that can affect every organ system.
Hematol Oncol Clin North Am @number@ 21 : 1115-40 ) underlined that cytogenetic assessment might also be useful for evaluating MM prognosis.
Hematoma and edema volumes were calculated from non-contrast CT.
Hematoma PS was lower than that in the contralateral regions ( p < @number@ ) .
Hematoma volume and MLS can be the most useful parameters for evaluating the ISH severity in the present experimental model.
Hematopoiesis has provided insight into the molecular basis of tissue homeostasis and malignancy.
Hematopoietic cell transplantation ( HCT ) is believed to halt progression of neurovasculopathy.
Hematopoietic cell transplantation ( HCT ) provides a life-prolonging or potentially curative treatment option for patients with hematologic malignancies.
Hematopoietic cell transplantation ( HCT ) remains a cornerstone of treatment of many hematologic malignancies but transplant-associated morbidity and mortality limit application to older patients.
Hematopoietic data show a significant increase in eosinophil and decrease in monocyte count in either sex.
Hematopoietic-specific microRNA-142 is a critical regulator of various blood cell lineages , but its role in erythrocytes is unexplored.
Hematopoietic stem and progenitor cells exhibited changes in frequencies with age that differed between blood and bone marrow.
Hematopoietic stem cells ( HSCs ) are responsible for the continuous regeneration of all types of blood cells , including themselves.
Hematopoietic stem cells ( HSCs ) replenish progenitor and precursor cells of multiple lineages , which normally differentiate into short-lived mature circulating cells.
Hematopoietic stem cells ( HSCs ) reside in specialized microenvironments known as niches.
Hematopoietic stem cells ( HSCs ) undergo a profound functional decline during normal aging.
Hematoproliferative change was characterized as exuberant proliferation of hematopoietic cells within the spleen that distorted but did not displace normal splenic morphologic features.
Heme ( iron protoporphyrin IX ) is an essential protein prosthetic group and signaling molecule required for most life on Earth.
Heme oxygenase-1 ( HO-1 ) has been recognized as a critical modulator of granuloma formation and programmed cell death in mycobacterial infections.
Heme oxygenase-1 ( HO-1 ) is a @number@ kDa protein which catalyzes the breakdown of heme to free iron , carbon monoxide and biliverdin.
Hemiarthroplasty has been the treatment of choice in patients with bone quality and fracture patterns not amenable to open reduction and internal fixation.
Hemichorea-hemiballism associated with non-ketotic hyperglycaemia is a rare dyskinetic syndrome during uncontrolled or undiagnosed diabetes.
Hemicraniectomy increases the chance to survive completely independent more than fivefold and doubles the chance to survive at least partly independent.
Hemispheres underwent neuropathologic examination for identification of AD pathology and other common age-related neuropathologies.
Hemispheric lateralization of movement control diminishes with age ; whether this is compensatory or maladaptive is debated.
Hemodialysis patients in Japan are aging and thus more patients need support for attending hemodialysis facilities.
Hemodynamic indices were measured using a brachial cuff-based oscillometric method.
Hemodynamic metrics ( that is , relative time to peak and amplitude ) were calculated with a γ-variate model.
Hemodynamic shear stress is the frictional force of blood on the arterial wall.
Hemodynamic variables also were recorded serially.
Hemodynamic variables , postoperative inotrope requirement , and outcome variables showed no differences between the groups.
Hemoglobin A1C ( A1C ) was measured from a finger-stick blood sample to assess blood glucose control.
Hemoglobin A1c , blood gases , and fasting c-peptide level were evaluated in all children.
Hemoglobin adducts have been recognized as a suitable biomarker for monitoring chemical exposure.
Hemoglobin and hematocrit are important determinants of blood viscosity and arterial oxygen content and may therefore influence cerebral blood flow ( CBF ) .
Hemoglobin concentration was positively associated with the energy and nutrient dietary intake , and negatively with age , BMI and functional status.
Hemoglobin was inversely correlated with Mg levels in the anemic group ( p < @number@ ) .
Hemophilia is caused by a functional deficiency of one of the coagulation proteins.
Hemophilia is caused by a functional deficiency of one of the coagulation proteins.
Hemorrhage occurred in @number@ ( @percent@ ) patients and vascular obstruction in @number@ ( @percent@ ) patients during the 2-year follow up.
Hemorrhagic scores were independently associated with non-use of VKA whereas thromboembolic scores were not associated with VKA use.
Hemostasis is an active process regulating the formation and dissolution of fibrin clot to preserve vascular integrity.
Hemostatic tools for liver surgery were used to control bleeding.
Hence , aberrant epigenetic patterns may be linked to circadian alterations in AD.
Hence , a better understanding of this type of memory is a priority in the field of public health.
Hence , a biopsychosocial approach may be more appropriate for a more lasting resolution to sexual dysfunctions in men.
Hence , a combined morpho-constitutional ( M-C ) classification has been proposed.
Hence , acupuncture may act as a stimulator activating peripheral nerves at specific acupoints and inducing the expression of various NTFs in the brain.
Hence , age-matched norms have to be considered while interpreting the results of cVEMP , especially in individuals above @number@ years of age.
Hence , agents are needed to improve glycemic control despite the inflammation.
Hence an accurate and reliable diagnosis of MCI can be very effective and helpful for early diagnosis of AD.
Hence , a negative association between sarcopenia severity and adiposity / metabolic biochemical markers was highlighted.
Hence an understanding of B cell immunosenescence in particular is vital in designing strategies to combat the effects of age on immune function.
Hence , appropriate assessment and management of the risk of falls in older adult patients are key elements of patient-centered care.
Hence , at the molecular level , SSc fibroblasts exhibit intrinsic characteristics of fibroblasts from aged skin.
Hence , a valid and reliable measurement of Sense of Coherence is pivotal.
Hence , cardiac dysfunction should be targeted as a potentially modifiable factor to prevent CMI-related brain injury.
Hence , cataract prevention is a big and true challenge , but a very difficult task to be accomplished.
Hence , changes in nAChR regulatory proteins such as Lynx proteins could underlie the dysregulation of nAChRs in AD.
Hence , changes in the network behavior are visualized at the same time.
Hence , changing the narrative about living long and well is the void addressed here.Life is ultimately terminal.
Hence , characterizing the prevalence and clinical accompaniments of these other tremors is of value.
Hence , conditions that induce HIPK2 deregulation would result in a dysfunctional response to stressors by affecting p53 activity.
Hence , contrary to our hypothesis , masseter spindles do not undergo major morphological changes between young age and adulthood.
Hence , CT imaging spans a wide range of applications in aortic valve disease , from basic research to diagnosis and treatment planning.
Hence , developing reliable in vivo measurements of brain iron content via magnetic resonance imaging ( MRI ) is of significant interest in human neuroscience.
Hence , effective systolic pressure lowering is particularly important in Asians yet blood pressure control remains inadequate despite the availability of numerous antihypertensive medications.
Hence , elder participants seem to routinely recruit this brain region in demanding tasks , irrespective of whether filtering or storing is challenged.
Hence FI-OutRef could be a biomarker of advancement of aging within the acute care setting.
Hence , fluctuations in the balance between lysine acetylation and deacetylation contribute to the final shape and performance of the brain.
Hence further studies are required to determine if sMRI can become an aid to current diagnostic practice in young adults with ASD.
Hence , future studies should investigate the long-term effectiveness of CMI in terms of fall prevention in older adults.
Hence , G6PD also has a pro-oxidant role.
Hence , genetic variants in DNA repair pathways could modulate treatment response.
Hence , gyrification may be what underlies the SA-GCA relationship.
Hence , HE is an attractive target resource for developing not only medicines , but also functional foods.
Hence , identifying lifestyle approaches that may prevent , delay , or treat cognitive impairment and dementia in older adults is becoming increasingly important.
Hence , in addition to specific serum tTG IgA , screening tests frequently include total IgA levels.
Hence , in a last part we will discuss the possible interventions susceptible to combat both T2DM and AD.
Hence , in elderly patients , a decrease in the levels of BMI , HDL , TC and LDL accompanies aging.
Hence , inhibition of translational machinery was the foremost reason for the early mortality in C. elegans.
Hence , innovative therapeutic strategies focused at controlling the circadian clock and the nutrient sensing pathways might beneficially influence the negative effects of aging.
Hence , interventions that would specifically target these PTMs are warranted to reverse myosin dysfunction in old age.
Hence , in this paper an attempt was made to summarize recent findings.
Hence , it appears as a structural component of autophagic flux.
Hence , it is important to develop an autonomous robotic system to perform remote ultrasound scans.
Hence , it is important to identify the protective factors.
Hence , it is impossible to detect an \ "initial insult \ " at an epidemiological level.
Hence , it is inadequate to rely on a single index to facilitate the classification of nasolabial folds.
Hence , it is not surprising that dysregulation in any protease function that affects ECM homeostasis may contribute to the aging process.
Hence , it is yet unclear whether BRCA1 / 2 mutation carriers may indeed be at risk of a reduced reproductive lifespan.
Hence , it might be a clinically useful predictor of non-AIDS-defining conditions.
Hence , it would be critical to further understand the molecular mechanisms involved in the communication between mitochondria and the rest of the cell.
Hence L1HS insertion polymorphisms are connected to samples , individuals , families and clinical conditions.
Hence , measuring saccadic eye movements should be considered as a tool for screening the fitness to drive.
Hence , miR-21 can be a potential therapeutic target for HTN.
Hence , mitophagy is a viable target to promote longevity and prevent age-related pathologies.
Hence , more attention should be paid to the paternal health , given its equivalently important role in affecting neurobehaviors of descendants.
Hence , more large-scale prospective data from multicenters will continually be required to aid in patient selection , reduce complications , and improve long-term outcomes.
Hence most of the frailty scales assess the physical , mental and social dimensions as well.
Hence , most patients with mitochondrial disease produced by defects in the oxidative phosphorylation ( OXPHOS ) system are susceptible to cardiac involvement.
Hence multidisciplinary approach to management of PD in older patients should be emphasized.
Hence naturally occurring anti-oxidant rich-herbs play a vital role in combating these conditions.
Hence , new therapeutic effects can be achieved , such as reduction of exudation secondary to age-related macular degeneration or diabetic maculopathy.
Hence , @number@ years is the usual limit , but between @number@ and @number@ is ART useful ?
Hence , OA should be considered a specific process and not simply an inevitable feature of ageing.
Hence older age , but not knee OA , was related to lowered muscle NKA content in older adults.
Hence , older men ( 70-77 years old ) displayed a poorer performance in comparison with the other age groups.
Hence our data support the concept that pathogenesis is affected by the generational age distribution of the infecting C. glabrata population in a host.
Hence , peak power was @percent@ lower in the old ( P < @number@ ) .
Hence , peripheral nerve blocks , epidural analgesia and regional anaesthesia have emerged as options in the delivery of adequate pain relief in hip fractures.
Hence pharmaceutical care discussions at home might improve treatment adherence.
Hence , pharmaceutical innovation is estimated to have increased mean age at death in Turkey by @number@ years during the period 1999-2008.
Hence , programmed cell death mechanisms , apoptosis and autophagy , play a vital role in the aging process.
Hence , quantitative MRI may compliment other imaging techniques in detecting early changes in DLB and in understanding neurobiological changes associated with the disorder.
Hence , severe test conditions are in demand for a better reproduction of the in vivo situation of TKR.
Hence , SIRT6 has been recently categorized as a tumor suppressor.
Hence , strength training can engender a stabilization of the muscular phenotype i.e. different isoforms of MHC.
Hence , the administration of general anesthesia to the elderly can be a very challenging task.
Hence , the aim of the present study was to examine possible age differences in the content of everyday PM intentions and their performance.
Hence , the calculation of the oVEMP 500 / 1000 Hz amplitude ratio may be a valuable diagnostic tool for Menière's disease.
Hence , the ' contract of endosymbiosis ' represents a compromise between the possibilities and perils of multicellular life.
Hence , the current findings can foster understanding of how expertise is positively associated with brain functioning during aging.
Hence , the decrease in polyethylene wear particle generation from the articulating surfaces is aimed at improving implant design and material.
Hence , the effects of age on modulation sensitivity remain unclear.
Hence , the fullerene nanoemulsion may assist in protecting collagen from breakdown with cosmeceutical benefit.
Hence , the goal is to explore the barriers to govern the scaling-up of the long-term care innovations.
Hence , the heart rate dynamics were closer to a 1 / f power law and most complex between @number@ and @number@ years.
Hence , the inability of standard treatment procedures to counteract the effects of soman poisoning resulted in the search for alternative strategies.
Hence , the management of older patients with HF is challenging and treatment should be modified in the light of the above-mentioned conditions.
Hence the need for renal replacement therapy is continually expanding.
Hence , the novel R1673P allele produces neurodegenerative phenotypes in flies and human , likely due to a toxic gain of function.
Hence , the observed differences between the two cueing types may be associated with the natural dependence of gait on visual information.
Hence , the potential involvement of nesprins in disease has expanded immensely on what we already know.
Hence , the predictive value of CWS may be expected to increase when assessed for walking in more realistic ( visually guided ) conditions.
Hence , the quality of life seemed to be independent of someone's age.
Hence , there has been some skepticism as to whether telomere length may be helpful in estimating cancer risk.
Hence , there is a need for the field to look at alternative approaches to therapy.
Hence there is demand for non-invasive tests for the early detection of CRC with high acceptance in population-wide screening.
Hence , the results of the present study suggest that AAC in these patients is strongly associated with oxidative stress.
Hence , thermogenesis-induced metabolic costs can be reduced during cold exposure , and hyperthermia associated to dehydration can be avoided during heat exposure.
Hence , the role for rehabilitation in the context of HIV , aging and comorbidities is emerging.
Hence , these results highlight that spectral and temporal auditory processing in the superior colliculus are impaired during aging.
Hence , these strains could become targets to develop disease-modifying therapies for CBD and AD.
Hence , the surgeon is the most important non-TMN prognostic factor in gastric cancer.
Hence , the temporal gradient in Korsakoff patients is not an artefact of either the AMI or the AI method.
Hence , the understanding of these expressions is essential for daily communication.
Hence , they have complex health and social service needs.
Hence , this might be pathophysiologically relevant in conditions of raised adenosine concentrations , such as hyperactive bladder contractility.
Hence , this research tests the hypothesis that humans learn strategies that make interactions predictable and robust to inaccuracies in neural representations of object dynamics.
Hence , this study can serve as a framework for developing tailored and differential intervention methods for these families.
Hence , this study supports the notion that co-expression of synphilin-1 promotes formation of autophagic-susceptible aggresomes and consecutively the degradation of human A30P alpha-synuclein.
Hence , this technique may prevent any contour irregularities.
Hence , TID reduction might be suggested as an early marker for subtle cognitive decline in aging.
Hence , transportation engineers and road safety professionals should consider appropriate countermeasures to reduce the risks of crashes involving ageing drivers at intersections.
Hence , treatment of these patients needs to be individualized.
Hence , understanding mechanisms of brain aging and identifying associated modulators may have profound consequences for the prevention and treatment of age-related impairments and diseases.
Hence , understanding the circumstances and reflections that influence the decision is greatly needed and little is known about potential gender difference influencing the choice.
Hence , understanding the factors required for optimal vaccine responsiveness is critical.
Hence , we classify them as \ "caloric restriction mimetics \ " ( CRM ) .
Hence , we conclude that AIT is superior to MCT for enhancing aerobic capacity.
Hence , we conclude that HET is superior to NET for enhancing aerobic capacity.
Hence , we examined the responsiveness of these two measures among individuals at risk of mobility impairment among adults aged ≥70 years.
Hence , we investigated the chronology of whole body , tissue , and cellular events that occur during the evolution of diet-induced NASH.
Hence , we propose that precise and early detection of aggresome-pathology can allow the timely assessment of disease severity in COPD-emphysema subjects for prognosis-based intervention.
Hence , we propose the use of a multifunctional dendrimer to solve the solubility and stability issues of resveratrol.
Hence , we provide first evidence for a relationship between PT connectivity , musicianship , and phonetic categorization.
Hence , we suggest sleep as a key mediator at the connection between stress and BDNF.
Hence , we tested whether body mass index ( BMI ) modified the genetic association of the apolipoprotein E ε4 allele with cognitive decline.
Hence we undertook an effort to design both inhibitors and activators using structure-based drug design techniques and report here the biological proof of concept.
Hence , we used themes from lay definitions of successful aging to quantify the prevalence of primary and secondary control beliefs over time.
Hence , we verified the mechanism by which SIRT1 regulates doxorubicin induced cardiomyocyte injury in vivo and in vitro.
Hence , we wondered to what extent specific BPS are associated with cognitive decline in participants with MCI or AD.
Hence , when designing technology for this population , developmental changes , such as attention and / or perception , should be considered.
Hence , with a focus on ortholog urinary peptides mouse ageing can be translated to human ageing.
Hence , xenogenic stem cell therapy was used in this study.
Hepatic and renal markers of damage were not modified.
Hepatic anti-inflammatory macrophage markers correlated positively with hepatic IS.
Hepatic expression of aquaporin @number@ ( AQP8 ) protein was @number@.5-fold higher in iH-HIFKO mice than in control mice.
Hepatic progenitor cells ( HPC ) appear in a variety of liver diseases.
Hepatic steatosis and its related inflammatory state ( steatohepatitis ) are the main hepatic complications of obesity and metabolic diseases.
Hepatic steatosis prevails each year.
Hepatitis B virus ( HBV ) infection is one of the main causes of HCC.
Hepatitis C , cirrhosis , autoimmune hepatitis , and inflammatory bowel disease are more prevalent than ever among older adults.
Hepatitis C virus ( HCV ) -specific CD4 + and CD8 + T cells are key to successful viral clearance in HCV disease.
Hepatitis C virus is a leading problem in PWH.
Hepatitis E ( HE ) is a zoonotic viral disease caused by hepatitis E virus ( HEV ) .
Hepatitis E virus ( HEV ) , the causative agent of hepatitis E , is an important public health problem throughout the world.
Hepatobiliary ultrasonography in sixth month follow-up showed entirely regression of cholelithiasis.
Hepatocellular carcinoma ( HCC ) is a common cancer with very poor survival due to lack of reliable biomarker for early diagnosis.
Hepatocellular carcinoma ( HCC ) is the third most common cause of cancer-related deaths worldwide.
Hepatocyte senescence induced a @number@.6-fold increase in total secreted protein ( P = @number@ ) without major alterations in the protein profile.
Hepatocyte transplantation is an alternative to whole liver transplantation.
( Hepatology @number@ ; 65 : 1237-1248 ) .
( Hepatology @number@ ; 65 : 694-709 ) .
( Hepatology @number@ ; 66 : 124-135 ) .
( Hepatology @number@ ; 66 : 1286-1295 ) .
( Hepatology @number@ ; 66 : 528-541 ) .
( Hepatology @number@ ; 66 : 616-630 ) .
( Hepatology @number@ ; 67 : 123-133 ) .
( Hepatology @number@ ; 67 : 188-203 ) .
Hepcidin antimicrobial peptide has taken center stage in recent years as a potent modulator of iron availability.
Hepcidin , a peptide hormone that regulates cellular iron export , is essential for the maintenance of iron homeostasis.
Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis.
He performed well on tests that are highly sensitive to acquired brain dysfunction.
He presented with memory problems , personality changes , and disorientation.
Her-2 / neu showed association with ER in the all the age groups while PR only showed association in the peri-menopausal and postmenopausal women.
HER-2 positive tumors are among the most aggressive subtypes of breast cancer and are frequently associated with metastasis and poor outcome.
Her blood pressure , serum electrolytes , and the hormonal states remained normalized for more than a year thereafter.
Her depressed mental state also improved after spironolactone.
Here , a 3D-printed anthropomorphic brain phantom with attachable striata in three sizes was designed to enable controlled volumetric changes.
Hereafter , home medical care will play an important role in order to build the integrated community care system by cooperating with long-term care services.
Here , age differences in this discrimination process were assessed by manipulating the overlap between cues present at encoding and retrieval orthogonally with cue-target distinctiveness.
Here , a group of @number@ healthy older adults and a comparison group of @number@ young adults completed a multidomain assessment of SA.
Here , a high-throughput screen was developed using an siRNA library for kinases that mediate NKX3.1 degradation.
Here , an association was found with a region of approximately 220kb on chromosome 5q11.1.
Here , an evolutionary hypothesis is presented that could answer all three questions , based on the following suppositions.
Here , a number of concepts are discussed that focus on this goal and its implications for the cancer patient and society at large.
Here , a refined scheme covering all potential biomarker constellations is proposed.
Here are tips for hiring and keeping staff.
Here a short description about telomere length variations and its association with human aging and age-related diseases is reviewed.
Here , associations between postural performance and corticosubcortical brain regions were examined in young and older adults using multiple structural imaging and linear mixed models.
Here , based on recent literature data , we investigate the possible link between telomere dysfunction associated cellular senescence and tumorigenesis.
Here cDNA clones encoding wild-type hUbb and the frame-shifted version hUbb ( @number@ ) were expressed in transgenic Drosophila using the doxycycline-regulated system.
He received treatment with thiamazole ( MMI ) for GD and desmopressin acetate ( DDAVP ) for CDI.
Here , comprehensively analyze of multidisciplinary fields highlights the contribution of TREMs locus to AD development.
Here , covariate-stratified reference intervals were determined for a number of special assays not previously reported.
Here , current global gene expression profiling studies on normal aging and age-related genetic / environmental interventions in widely-used model organisms are briefly reviewed.
Hereditary amyloidosis type IV also presents with a bulbar neuropathy that mimics motor neuron disease.
Hereditary amyloidosis type IV presents with bulbar motor neuropathy and not with peripheral neuropathy as occurs with common forms of amyloidosis.
Hereditary diffuse leukoencephalopathy with spheroids ( HDLS ) is a familial neurodegenerative disease clinically characterized by progressive cognitive and motor dysfunction.
Hereditary motor and sensory neuropathy with proximal predominance ( HMSN-P ) is a rare disease so far identified only in individuals of Far East ancestry.
Here , fibroblast , epithelial and neuronal cell lines were exposed to Aβ 1-40 or Aβ 1-42 and challenged with HSV-1.
Here , for the first time , we studied the impact of these practices on the spinal neural activity of experts and novices.
Here he talks about art , old age and the passing of time.
Here , I discuss a mechanistic basis for hormesis and its implications for cancer prevention and healthy aging.
Here , I discuss several possible explanations , such as intrinsic limitations in longevity association studies and the complex genetic architecture of longevity.
Here , I discuss the origins , prevalence and implications of somatic mosaicism in healthy human tissues.
Here I discuss why the link between arrest and senescence is semi-coincidental and how senescence is related to aging and cancer.
Here I examine the relationship between the awareness of the phenomenal qualities of subjective experience ( qualia and free will ) and general cognitive tendencies.
Here , I have characterized the Drosophila ortholog of the human TGF-β Inducible Early Gene @number@ ( dTIEG ) .
Hereinafter , the category system that has been derived from the theoretical considerations will be presented and an outlook will be given.
Herein , a practical radiosynthesis of [ ( @number@ ) F ] CABS13 was achieved by radiofluorination followed by deprotection of an O-benzyloxymethyl group.
Herein , a variety of cosmeceuticals are discussed , including retinoids , niacinamide , and glycolic acid.
Here , inhibition of Bruton's tyrosine kinase and phosphatidylinositol 3-kinase delta currently offer the most promising targeted approaches.
Here , in parallel auditory experiments with older rats and humans , we evaluated a targeted cognitive training approach that adaptively manipulated distractor challenge.
Herein , research findings over the past @number@ yr will be reviewed.
Herein the authors examined the methylation levels of @number@ CpG sites in @number@ samples from adult peripheral blood.
Herein , the entire RIC3 gene was sequenced in a French-Canadian and French sample series of @number@ PD patients and @number@ unaffected controls.
Herein , the neuroprotective potential of curcumin , with emphasis on Alzheimer's disease , as well as its limitations will be discussed in detail.
Here , in this brief review , we will focus the discussion on this ambiguous role of autophagy in the development and progression of cancer.
Here in this study , we examined age-related changes in the quality of memory reactivation on subsequent memory.
Herein , we address the impact of proteostasis defined by the FoldFx model on our understanding of protein folding and function in biology.
Herein , we address the importance of genes involved in epigenetic mechanisms during senescence and how their effects might determine senescence bypass and immortalisation.
Herein we aimed to determine at which points geriatric assessment of the cases with acromegaly differs from that of general elderly population.
Herein , we aimed to evaluate the associations between bipolar course of illness parameters and WML measured with volumetric analysis.
Herein , we argue that social agents have the largest influence on RAEs.
Herein , we assessed the prevalence and association of dysphagia with potential risk factors in 50- to 79-year-old adults dwelling in a community in Japan.
Herein , we characterize the impact of microRNA-142 on erythrocyte physiology and molecular cell biology , using a mouse loss-of-function allele.
Herein , we clarify the molecular aspect of the FOXO family in skin wound healing.
Herein we compare morphologic and functional characteristics , and disease evolution , in a transgenic mouse and a single family with a MHC mutation.
Herein , we demonstrate that eIF2αP guards cells from intracellular reactive oxygen species ( ROS ) via the inhibition of senescence.
Herein , we describe \ "prevention and management \ " of diabetes mellitus , focusing on the lifestyles of elderly diabetics.
Herein , we discuss the information gap for older individuals and the need for a better understanding of the effect of aging on drug responses.
Herein , we discuss the mechanisms of action and potential benefits of metformin.
Herein , we evaluate a radiofrequency treatment that provides novel real-time subdermal and epidermal temperature monitoring.
Herein , we examined the phosphorylation profile of sMyBP-C in mouse and human fast-twitch skeletal muscles.
Herein we examine separately the water-soluble ( WS ) and water-insoluble ( WI ) crystallin fractions and identify sites of isomerization and epimerization.
Herein , we first observed that human olfactory peduncle and cortex are enriched in SOM cells and fibers , in aged postmortem brains.
Herein , we found that L1 and L5 subfractions of LDL and VLDL , but not HDL , enhanced breast cancer cell viability.
Herein , we further found that overexpression of CUTA increases intracellular copper level , whereas copper treatments promote CUTA expression.
Herein , we hypothesize that pyrroloquinoline quinone ( PQQ ) can act as a Sirt1 / Sirt3 activator.
Herein , we hypothesize that rigorously quantifying entire radiodensitometric distributions elicits more muscle quality information than average values reported in extant methods.
Herein we identify predictors for viral decline in a cohort of HCV-infected postpartum women.
Herein , we illustrate the case of an 80-year-old man who presented with a slowly growing papule of the lower eyelid.
Herein , we intend to sum up our understanding about the role of SIRT1 and AMPK in osteogenic and adipogenic potential of MSCs.
Herein we investigated whether progranulin ( PGRN ) , a chondroprotective growth factor , is associated with IVD degeneration.
Herein , we present a case report of a 29-year-old female with Kienbock's disease in whom the X-ray was negative and MRI incorrect.
Herein , we present a multicenter prospective analysis between @number@ and @number@ investigating current trends in the prevalence and characteristics of IPUs in Japan.
Herein , we present an elderly male patient with anti-Ro-positive SLE associated with prolonged QTc interval and AV blocks that significantly improved after corticosteroid treatment.
Herein , we present a synopsis of the UPS components and of their functional alterations during cellular senescence or in vivo aging.
Herein , we primarily focus on the in vivo pharmacological effects of RSV reported over the past @number@ years ( 2009-2014 ) .
Herein , we propose ginsenoside F1 as a potential therapeutic strategy for reducing the deleterious contribution of senescent astrocytes in aged brain and related diseases.
Herein , we propose that there exists a time point at which the degenerative process is accelerated , leading to the appearance of clinical symptoms.
Herein , we provide a review on how the brain barriers change during aging and in AD and how these processes impact on brain function.
Herein , we reconstructed human epidermis from UVB-irradiated keratinocytes ( UVB-RHE ) .
Herein , we report an Argentinean family , of Basque ancestry , with an extensive family history of behavioral variant of FTD.
Herein , we report for the first time an increase in MDA concentrations determined by HPLC in human tears based on age.
Herein we report novel chroman-4-one and chromone-based SIRT2 inhibitors containing various heterofunctionalities to improve pharmacokinetic properties.
Herein , we report six cases of ViV procedures with the Edwards Sapien @number@ THV with a focus on technical considerations.
Herein , we report that Sam68 regulates isoform expression of the ribosomal S6 kinase gene ( Rps6kb1 ) .
Herein , we report that X-box binding protein @number@ ( XBP1 ) may be one of the earliest proteins engaged in response to ER stress.
Herein , we review select topics that shed light on these processes and suggest new treatment strategies.
Herein , we review the molecular pathways that underlie cellular senescence and how it contributes towards tumour suppression.
Herein , we review these hypotheses as well as potential therapeutic approaches.
Herein , we showed that secondary metabolites of marine Pseudomonas sp.
Herein we show that K52-acetylated RhoGDIα is specifically deacetylated by the sirtuin deacetylase Sirt2.
Herein , we show that telomere length regulation in murine and bovine blastocysts differed between trophectodermal and inner cell mass cells in a species-specific manner.
Herein , we update our knowledge on the main pharmacological activities and possible molecular targets of LBPs.
Herein , we use auxiliary data to adjust for informative loss to follow-up.
Here , I present the recent findings in our laboratory on the disruption of the neural network in human.
Here , I provide an overview of these studies and discuss their implications for tumourigenesis.
Here , I review recent studies of telomere length dynamics with particular relevance to immune function.
Here , Isl1 expression was detected in the genital region within the critical time frame for human CBE development.
Here is reported the characterization of the antioxidant properties of an aqueous poplar bud ( Populus nigra ) extract.
Here , I summarize our current understanding of epigenetics and it affects gene expression , with impacts on health and aging.
Here I will review about the effective and problem with bisphosphonate for the lifestyle-related disease with arteriosclerosis.
Here , key findings leading to our current view of DDR are discussed as well as potential areas of importance for future studies.
Here , key product-use related aging and transformation processes affecting ENPs are reviewed.
Here , levels of a small number of microRNAs implicated in normal neuronal function and / or plasticity were examined in an AD model.
Here , loneliness serves as a motive for performing volunteer work.
Here , long-term analyses based on @number@ years of follow-up of survival and of change in functional competence between intervention and control group are presented.
Here , mechanisms through which melatonin exerts its protective role against mitochondrial dysfunction associated with aging and age-associated disorders are discussed.
Here mild zinc deficiency is a common condition , documented by a decline of serum or plasma zinc levels with age.
Here , Montagne et al.
Here , @number@ celebrity pictures are employed to evoke moral discussions , with a focus on adultery and homosexuality.
Here , @number@ celebrity pictures are employed to evoke moral discussions , with a focus on adultery and homosexuality.
Here @number@ younger adults and @number@ older adults performed four tasks that measured strategic and binding aspects of memory.
Here , one aspect of metamemory function belief in strategy efficacy-was tested for a role in the effective use of encoding strategies.
Here , our review describes supporting evidence that the acute inflammatory response also guides the generation of healing and regenerative mediators after cardiac damage.
He reported no previous history of endocrinopathy and no known hypercoagulability risk factors.
Here , proteomic screening of synaptosomes from HIV / gp120 transgenic mice was conducted to determine potential neuronal markers and drug targets associated with HAND.
Here recent studies concerning the use of PRP in the treatment of chronic ulcers and soft tissue defect are reviewed.
Here , recent studies examining the role of cellular senescence and of oxidative stress in SSc pathogenesis will be reviewed.
Here , SIRT5 was observed to bind to cardiolipin via an amphipathic helix on its N terminus.
Here , sleep alterations in AD and its pre-dementia stage , mild cognitive impairment , and their complex interactions are reviewed.
Here , the aim was to review the knowledge of miRNA expression and action in the islet of Langerhans.
Here the authors report the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.
Here the authors show that in response to muscle injury , macrophages secrete Adamts1 , which induces satellite cell activation by modulating Notch1 signaling.
Here the authors summarise the literature of a re-discovered , current clinical phenomena , frailty syndrome , focusing on the practical issues in primary care.
Here , the basement membrane of human retinal microaneurysms has been analyzed during aging.
Here the complexity of E2's widespread effects comes into play and makes interpretation of findings more challenging.
Here , the contribution of astrocytes and their ability to influence DAergic neurodegeneration , neuroprotection and neurorepair will be discussed.
Here , the effects of various doses and molecular weights of CH from silver carp skin on photoaging in mice were investigated.
Here , the formation and growth of crystals were closely related to collagen fibrils , which served as guide rails for the expansion of mineralization.
Here , the impact of vascular degradation in the absence of disease was investigated within @number@ groups of healthy younger and older adults.
Here , their effects on cutaneous aging by means of objective instrumental measurements were elucidated.
Here , the mechanisms of redox regulation in normal stem cells , cancer cells , and cancer stem cells are reviewed.
Here the Mm.
Here , the molecular mechanism of the inhibition of Sirt3 by SRT1720 is described.
Here , the possible modulatory effect of physical similarity between the observer and the agent was investigated in three studies.
Here the potential use of binary systems to enhance in vitro and in vivo activity of trans-resveratrol was investigated.
Here , the prediction accuracy was @number@
Here , the role of CONTEXT : Fragmentation in geriatric hip fracture care is a growing concern because of the aging population.
Here the wave speed actually diminishes as the degree of tethering increases.
Here , this framework is extended to the focused attention task where subjects are asked to respond to signals from a target modality only.
Here , this paradox is traced to the decline of multiple protective mechanisms at many length scales from nanometres to that of the whole femur.
Here , this review will describe the changing behavior of microglia from development and birth through to the aged brain.
Here , through genetic fine-mapping , we define a set of tightly linked variants likely to contain the causal allele ( s ) .
Heretofore , access to RRT in developing countries has been limited due to economic limitations.
Heretofore , the effects of aging upon ROS and RNS formation were not investigated in humans , which is the focus of the current study.
Hereto , in @number@ healthy subjects , segmental PreS and SS were measured on tissue Doppler images of six left ventricle walls.
Here , using cortical thickness , we investigated the modular organization of the cortical structural networks in @number@ young and @number@ normal aging adults.
Here , using data generated by eleven groups worldwide , the authors show that SWATH-MS is capable of generating highly reproducible data across different laboratories.
Here , using genetic knockdown , we uncover the role of Numb , an endocytic adaptor protein , in regulating the late steps of autophagy.
Here , we address a methodology that utilizes a modified stretched exponential survival function where a stretched exponent is relevant to heterogeneity in human populations.
Here , we address downstream targets of mTOR signalling and their possible links to ageing.
Here , we addressed the basis for this genetic association using Trem2 ( - / - ) mice.
Here , we addressed the pathogenicity of these mutations in transgenic mice expressing human ADAM10 in brain.
Here , we addressed the potential role of hyper-binding in paired-associate learning.
Here we addressed this gap in knowledge by determining the levels of ALF components in the aging lung that are important in controlling infection.
Here we addressed this problem by examining whether human 3D facial imaging features could be used as reliable aging markers.
Here we addressed whether fibroblast ageing analysedex vivo entails genome instability.
Here , we address the hypothesis that disruption of the intestinal barrier is associated with aging.
Here we address this mechanism , focusing on the contribution of two mitotic motors , Kid and CENP-E.
Here , we address this question by validating the method on @number@ common clinical biomarkers from three longitudinal cohort studies and one cross-sectional survey.
Here we address this question in the framework of the emergence of shared linguistic categories in a population of individuals interacting through language games.
Here , we address this question using a mouse model expressing the entire human tau gene with an FTD-associated mutation ( V337M ) .
Here we address two reasons conventional spectral analyses may have led to inconsistent results.
Here , we aimed at identifying the genetic basis for autosomal dominant non-syndromic hearing loss ( ADNSHL ) in a large German family.
Here , we aimed to assess whether cognitive impairment in PD could drive these differences.
Here we aimed to clarify the differences in clinical features between suspected familial colorectal cancer type X and Lynch syndrome in Japanese patients.
Here , we aimed to confirm whether masticatory dysfunction by ageing is inevitable.
Here , we aimed to evaluate the nature of these relationships with respect to causality.
Here we aimed to investigate the influence of SIRT1 polymorphisms on individual susceptibility to MI.
Here we aimed to investigate the topographical distribution of age-related cortical atrophy and to compare it with that associated with prodromal and estabilished AD.
Here , we aimed to investigate whether a similar Reelin-associated neuropathology is observed in the aged human hippocampus and whether it correlated with dementia status.
Here , we aimed to quantify the extent of lesion volume change and brain atrophy in the chronic poststroke brain using magnetic resonance imaging.
Here we aimed to systematically assess effects of grapes on regional cerebral metabolism.
Here , we aim to analyse the different ageing mechanisms with regard to HIV infection.
Here , we aim to characterize the contribution of HIF1 in xenophagy , a specialized form of autophagy involved in the degradation of intracellular bacteria.
Here , we aim to determine whether this sequence is a risk factor in Eastern Chinese ALS patients.
Here we analysed @number@ mutations from @number@ cancers and extracted more than @number@ distinct mutational signatures.
Here , we analyzed ABCA7 expression in a set of human brain samples as a function of AD-associated SNPs and AD status.
Here , we analyzed fibroblasts from healthy subjects and HGPS patients using SILAC ( stable isotope labeling with amino acids in cell culture ) .
Here , we analyzed gene expression profiles of monocytes from symptomatic ACHF patients ( NYHA Class III-IV ) before and after pharmacological treatment with CD.
Here we analyzed next-generation sequencing ( NGS ) data for small RNAs in VZV-infected fibroblasts and human embryonic stem cell-derived ( hESC ) neurons.
Here , we analyzed physiological changes in sodium channel metabolism in BACE1-null mice.
Here , we analyzed the plasma concentration of collagen-derived peptides after ingestion of high tripeptide containing collagen hydrolysate in humans.
Here we analyze the more recent findings in telomerase activation as a potential key modulator for human healthspan and longevity.
Here we applied a machine learning approach to identify immune signatures predictive of individual-level protection against clinical disease.
Here , we applied high-throughput mass spectrometric analyses of mouse organs to define the repertoire of cyclin E protein partners in vivo.
Here , we apply hypergraph analysis , a method from dynamic network theory , to quantify individual differences in brain functional dynamics.
Here , we apply the method to a large set of healthy controls spanning six decades of age.
Here , we apply the same analytic approaches to a pathological case-control series and show a predictive AUC of @percent@.
Here , we are going to review the immunological changes associated with the aging process relevant for transplantation.
Here we are providing a concise overview on current mass-spectrometry-based methodologies to detect reversible cysteine oxidation and irreversible protein carbonyl formation in proteomes.
Here , we are the first to investigate whether the expression of Jagged1 in endothelial cells ( ECs ) may regulate apoptosis of VSMCs.
Here we argue that studies have overlooked evidence for variation in male reproductive ageing across human populations.
Here we argue that this primitive pattern is also characterized by sexual dimorphism in the pelvic canal shape , implying complicated deliveries.
Here we argue that trade-off-like and conditional effects of genes can play central role in this phenomenon and in determining longevity.
Here , we asked , to what extent is motor adaptation to novel dynamics maintained in older adults ( ≥65 yr ) ?
Here we assay @number@ million CpGs in each of @number@ brain samples representing different individuals and brain regions.
Here , we assessed glucose tolerance and body composition in mice carrying the human polymorphism.
Here , we assessed the contribution of MATR3 variants in a cohort of @number@ Italian ALS patients.
Here , we assessed the effect of aging on implicit vs. explicit learning within the same task.
Here we assessed the effects of cell density on AβPP processing in neuronal and non-neuronal cell lines , as well as mouse primary cortical neurons.
Here , we assessed the hypothesis that mtSNPs may confer a risk for atherosclerosis , the most important intermediate phenotype of ischemic cardiovascular events.
Here we assessed the prevalence and distribution of HPV genotypes in Fujian population.
Here we assessed this regional reliability.
Here , we assessed vinyl sulfone small molecule peptide caspase inhibitors for potential use in vivo.
Here , we assessed whether overall malnutrition and / or specific nutrient deficiencies were associated with HAI via alterations in immune parameters.
Here , we assessed whether these differences change over time and the relation with dysglycemia.
Here we assess the contribution of ageing and related factors to hospitalisation days in Hong Kong.
Here , we assess the extent to which norms for these tasks must take into account ageing , sex , and testing country.
Here we attempt to provide a comprehensive overview of the consequences of genomic instability in the nervous system.
Here , we briefly describe the relationships between mitochondrial O ( @number@ ) ( - ) and aging phenomena in mev-1 animal models.
Here , we briefly discuss the intimate relationship between the autophagic preservation of intracellular and organismal fitness and healthy aging.
Here , we briefly review research on the genetic and environmental causes of PD.
Here , we briefly review the biological , social and behavioural factors that may contribute to women's greater longevity.
Here , we briefly summarize current technologies and then elaborate on emerging novel concepts that may further propel the field.
Here , we carried out whole-exome sequencing ( WES ) on @number@ Finnish patients with early-onset PD.
Here , we challenged our hypothesis that melatonin will impart antiproliferative response against PCa via inhibiting Sirt1.
Here , we challenge this concept by presenting evidence that skin-specific deletion of SIRT6 in the mouse inhibits skin tumorigenesis.
Here , we characterize a novel histone modification , the methylation of histone H4 at aspartate @number@ ( H4D24me ) .
Here , we characterize SPRTN as a specialized DNA-dependent and DNA replication-coupled metalloprotease for DPC repair.
Here , we characterize the SIRT6 interactome and identify 80 + novel SIRT6-interacting proteins.
Here , we combined computational modeling with quantitative mouse and patient data to investigate whether substrate competition affects pathway robustness in mFAO disorders.
Here , we combined several approaches to investigate GHB capacity to protect human neuroblastoma SH-SY5Y cells against hydrogen peroxide ( H2O2 ) -induced death.
Here we comment on three points in Chappell and Hollander's lead article.
Here , we compared the impact of CR and RM on cellular metabolic status.
Here , we compared the turnover dynamics of endogenous ubiquitinated proteins by proteasomes and autophagy by assessing the effect of their inhibitors.
Here we compare the existing DEB-based modelling approaches and , then , discuss how new biological evidence could be incorporated within a DEB framework.
Here we conduct an in-depth analysis of epigenetic drift in blood tissue.
Here , we conducted a large-scale RNA-sequencing-based expression quantitative trait loci study ( eQTL ) with subsequent heritability analysis.
Here , we conducted an exome-chip association analysis by genotyping @number@ Chinese individuals from a community-based cohort and two clinic-based cohorts.
Here we conducted three experiments to investigate whether the survival advantage also occurs for healthy older adults.
Here , we confirm that human tau increases Aβ levels.
Here we confirm that silencing of PERK extends autophagy-dependent survival , whereas the IRE-1-controlled apoptosis inducer is downregulated during ER stress.
Here , we consider a simplified model to extract the properties of this approach.
Here , we consider the power of studying ' endophenotypes ' in the context of ageing.
Here , we constructed a firefly luciferase reporter driven by the human telomerase reverse trancriptase ( hTERT ) gene promoter to screen for inhibitory compounds.
Here , we constructed a single-mutant transgenic ( Tg ) model harboring the PS1V97L mutation and used Non-Tg littermates as a control group.
Here , we correlated the Alu methylation level of blood cells with bone density in @number@ postmenopausal women.
Here , we could demonstrate the expression of MDH1 in neurons as well as in the neuropil.
Here , we created transgenic wild type and mutant genomic rescue constructs with the two noted conserved point mutations.
Here , we critically review the current evidence regarding autophagy in the kidney , in particular as assessed with tissue- or cell lineage-specific autophagy-deficient mice.
Here , we criticize the value of these features based on the numerous intrinsic inconsistencies in the data and in the rationale behind SMT.
Here , we demonstrate analysis of early infant brain maturation from longitudinal DTI with up to three time points.
Here , we demonstrate a positive correlation between the progression of AD histopathology and the activation of IRE1 in human brain tissue.
Here we demonstrate contrasting aftereffects of adaptation to facial age.
Here , we demonstrate correlations between the signal complexity of brain and cardiac activity.
Here , we demonstrated a method for fabricating an all-glass microfluidic cell culturing device having filters structure.
Here , we demonstrated normal human oral keratinocytes transcriptional signature profiling to senescence and differentiation.
Here , we demonstrated that As Hypertension is among the leading risk factors for cardiovascular disease and accounts for @percent@ of adult deaths worldwide.
Here , we demonstrate for the first time that the replicative age of the fungal pathogen Cryptococcus neoformans contributes to persistence during chronic meningoencephalitis.
Here , we demonstrate in detail the power of DNA / RNA chimera / AgNC probes in detecting two human miRNAs , let-7a and miR-200c.
Here , we demonstrate that a direct interaction of Arg1 with NOS2 is necessary for its S-nitrosation.
Here , we demonstrate that c-ABL tyrosine kinase regulates p53-dependent induction of p21.
Here , we demonstrate that caveolin potently enhances insulin receptor ( IR ) signaling when overexpressed in the liver in vivo.
Here , we demonstrate that Gal4-tagged and untagged C-terminally truncated ORF2p fragments possess residual potential to drive Alu retrotransposition.
Here , we demonstrate that in addition to its anti-apoptotic function , sAPPα has effects on neuronal proteostasis under conditions of proteasomal stress.
Here , we demonstrate that insulin increases the excitability of these neurons in control mice.
Here , we demonstrate that insulin signalling protects LAN5 cells by amyloid-β42 ( Aβ ) -induced toxicity.
Here we demonstrate that not only cortical cells are affected by this repetitive stimulation but also transmission at the corticomotoneuronal synapse at the spinal level.
Here , we demonstrate that PSC-CMs mature into adult CMs when transplanted into neonatal hearts.
Here we demonstrate that Sirt1 , Sirt2 , and Sirt3 are expressed in enucleate platelets.
Here , we demonstrate that SMN protein is significantly reduced in the spinal cords of patients with sporadic ALS.
Here , we demonstrate that subjects ' sensitivity to observed movement speeds is dependent upon how quickly they themselves executed the observed action.
Here we demonstrate that tau acetylation inhibits tau function via impaired tau-microtubule interactions and promotes pathological tau aggregation.
Here , we demonstrate that T-cell receptor ( TCR ) activation down-regulates distal Runx1 transcription , resulting in a significant reduction of Runx1 protein.
Here we demonstrate that treatment of aging cells with cytochalasin B substantially decreases cell size.
Here , we demonstrate the potential of these data to predict future depression status.
Here , we demonstrate whole-body quantitative SPECT imaging of preneoplastic breast cancer tissue using ( @number@ ) In-labeled cCPE.
Here , we derive a probabilistic extinction model that predicts the extinction risk of mammals at any body mass without invoking selective human harvest.
Here , we describe a 2-year-old patient with a previously undescribed phenotype including right ventricular cardiomyopathy , progeroid features , and premature death.
Here , we describe a Drosophila melanogaster open reading frame ( ORF ) that shares sequence and functional similarities with vertebrate Aven genes.
Here , we describe a general approach for immunopurification and MS-based identification of acetylated proteins in biological samples.
Here we describe age-related change in abdominal tissues observable in computed tomography ( CT ) scans.
Here , we describe a memory task designed to assess the accuracy of discrimination ability for the locations of objects.
Here we describe a model of HT1080 fibrosarcoma cells with an inducible senescence phenotype.
Here , we describe and characterize an Snx27-deleted mouse model for the ependymal layer defects of deciliation and hydrocephalus.
Here , we describe a new interaction partner for CSB , the DNA glycosylase NEIL2.
Here , we describe a new phenotype , which overlaps with other known CL syndromes.
Here , we describe a novel assay using a mutant telomerase that adds a well-tolerated variant telomeric repeat sequence to telomere ends.
Here , we describe a novel method to measure the relative telomere DNA content by dot blot analysis.
Here , we describe a novel platform that exploits microfabrication techniques to pattern cells in a fixed microarray.
Here we describe a novel RNA amplification approach that allows for high fidelity gene profiling of individual cells.
Here we describe a number of different patients presenting in a CMHT who have been assessed and investigated for Parkinson's disease.
Here we describe a peptide microarray system displaying @number@ human acetylation sites for the parallel characterisation of their modification by deacetylases.
Here we describe a phased mass spectrometry-based approach for the discovery , screening , and validation of circulating protein biomarkers with diagnostic value.
Here we describe approaches to capturing biological data , representing data in terms of networks and interpreting their meaning in relation to the human population.
Here , we describe approaches used to study CMA in different experimental models.
Here we describe a procedure for digital image analysis of cells stained by the SABG staining technique at pH @number@ or at pH @number@
Here , we describe a protocol for inducing cellular senescence by oncogenic RAS in primary human fibroblast.
Here we describe a sensitive method that uses ( @number@ ) P-labeled NAD and thin-layer chromatography to detect sirtuin-catalyzed deacylation reactions.
Here we describe a simple and improved protocol designed for a search of direct PPI inhibitors.
Here , we describe a stepwise approach towards this , moving from traditional two-dimensional non-contact co-cultures to new three-dimensional models utilising fibrin matrices.
Here , we describe basic science work carried out within the VETSA MRI study that provides meaningful contributions toward the study of neuropsychiatric disorders.
Here we described the methods using this assay to study the substrate utilization and mitochondrial function in a human hepatocellular carcinoma cell line , Huh7.
Here , we describe EpiDiff ( @url@ , an integrated software platform that supports quantification of epigenetic difference and identification of DEMRs by Shannon entropy.
Here we describe how telomere length regulates gene expression long before telomeres become short enough to produce a DNA damage response ( senescence ) .
Here we describe how the process of aging affects pathways that control the processing and degradation of abnormal proteins including amyloid-β ( Aβ ) .
Here we describe our search for effective drugs for primary refractory lymphoma cells with MYC rearrangement.
Here we describe performance on the Spanish version.
Here we describe protein expression abnormalities in brain regions of 12-month-old male Ts65Dn mice.
Here , we describe recent observations that link these important cellular processes.
Here we describe reduced chemotaxis but preserved chemokinesis toward a range of inflammatory stimuli in migrating neutrophils isolated from healthy older subjects.
Here we describe representations of time in Pormpuraaw , a remote Australian Aboriginal community.
Here , we describe some of the outstanding research questions concerning the NPC , its assembly and functions.
Here , we describe the case of a postmenopausal woman who took oral alendronate for > 3 years for osteoporosis.
Here we describe the characterization of DDX39 DEAD-box RNA helicase as a novel TRF2-interacting protein.
Here we describe the collection of RNAs regulated by AUF1 ( AU-binding factor @number@ ) , an RBP linked to cancer , inflammation and aging.
Here we describe the development of sleep and wake across the zebrafish lifespan and how it compares to humans.
Here , we describe the first reported case of a patient with the complication of pulmonary eosinophilia in the course of invasive mucormycosis.
Here , we describe the identification of protein clusters differentially expressed in high-grade versus low-grade gliomas.
Here , we describe the KR-TEL ( KillerRed induced DNA damage at telomeres ) system that induces site-specific oxidative damage at telomeres.
Here , we describe the main molecular features of the pathway , its regulation , cross-talk with other degradation pathways and importance in disease.
Here , we describe the modification of sealed PDMS microchannels using an oxygen plasma pretreatment and poly ( ethylene glycol ) grafting approach.
Here we describe the production of a secreted , soluble recombinant gp41 in @number@ cells.
Here we describe the profile of and factors associated with HRQoL among stroke survivors in Ghana.
Here , we describe the proteomic identification of novel UVA-targets in human dermal fibroblasts following a ( 2D-DIGE ) approach.
Here , we describe the protocol , its feasibility and the characteristics of the patients enrolled in the study.
Here we describe the relative contributions of infections and NCDs to hospital admissions and mortality , according to age , in Malawi's largest hospital.
Here we describe the results when an age-based estimate of the peripheral value is used , thus avoiding the peripheral setting.
Here , we describe the transitions in the gene expression profiles of @number@ KCNJ genes from healthy or dilated cardiomyopathic human hearts.
Here we describe the two cohorts that provide the data and biospecimens being exploited for our pipeline and describe the available unique datasets.
Here we describe the unprecedented role of SMPD3.
Here , we describe the whole genome sequences of @number@ female octogenarians.
Here , we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes in SVD.
Here , we describe this method using Hela carcinoma cells as an example.
Here , we describe this method using HeLa carcinoma cells as an example.
Here , we describe two illuminating patients with frontotemporal dementia due to the C9orf72 repeat expansion.
Here , we describe use of quantitative in vivo stable isotope labeling in mammals to accurately compare serum proteomes of wild-type and dystrophin-deficient mdx mice.
Here we detail how one can expand on this success and systematically identify genetic risks that lead or predispose to disease using next-generation sequencing.
Here we determined how age is associated with resting state sensorimotor functional connectivity , and whether connectivity strength is associated with motor performance.
Here , we determined if and how aging affects the ratio between Treg and Teff cells.
Here , we determined the crystal structure of human SerRS in complex with Ser-SA , an aminoacylation reaction intermediate analog , at @number@ Å resolution.
Here we determine how several aspects of the SC's mechanical properties are dramatically degraded with age.
Here we develop an analytic strategy to answer this question.
Here , we develop a new mathematical model of the population dynamics of erythrocytes that quantitatively describes ribavirin-induced anemia in HCV patients.
Here we develop a Tool for Ig Genotype Elucidation via Rep-Seq ( TIgGER ) .
Here , we developed a computational model that reproduced available experimental oxygen distributions for intact and degraded human vitreous in physiologic and environmentally perturbed conditions.
Here , we developed a continuous probabilistic pulsatility model for importance-weighted blood pulse waveform extraction.
Here , we developed a genetic risk score ( GRS ) for AMD based on @number@ risk variants from eight gene loci.
Here , we developed a method to measure serum levels of RNase-L and analyzed the relationship between RNase-L and metabolic syndrome ( MetS ) .
Here , we developed a mouse model of n-3 PUFA deficiency lasting from adolescence into adulthood.
Here , we developed a new Timeline procedure to directly compare the early memories reported by children , adolescents , and adults.
Here , we developed viral-based methods for the in vivo detection and manipulation of the activity-dependent microRNA , miR-132 , in the mouse hippocampus.
Here , we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebrates , using the naturally short-lived African turquoise killifish.
Here , we directly ask whether DNA methylation is altered following skin aging and / or chronic sun exposure in humans.
Here , we discovered that nuclear receptor Nur77 expression is lower in the hypothalamus of obese mice compared with normal mice.
Here , we discover poly ( ADP-ribose ) polymerase @number@ ( PARP1 ) as a novel KLF4-interacting partner.
Here we discuss another aspect of SirT1 biology , its function as a stem cell pluripotency and differentiation regulator.
Here we discuss current research findings focusing on the role of fibrosis , in arrhythmogenesis.
Here we discuss homeostatic causes for B lineage immunosenescence , and the potential for its rejuvenation.
Here , we discuss how ageing responds to natural selection on traits that arise as a consequence of sexuality.
Here , we discuss how the approach to midface rejuvenation has evolved over time owing to our increased understanding of the aging process.
Here we discuss HP activation and cellular protein quality control mechanisms that result in stress resistance and suppression of age-related proteotoxicity.
Here we discuss new findings related to COX-2 inflammatory and anti-inflammatory responses.
Here we discuss one aspect of drug development rodent models and propose an alternative approach to discovery research rooted in evolutionary experimentation.
Here , we discuss options available for senescent cells to maintain chromatin structure and the relative contribution of histone variants and chaperones in this process.
Here we discuss patterns of aging-related ovarian decline in diverse female vertebrates , and place human ovarian aging in comparative context.
Here , we discuss recent developments in small molecules targeting anti-apoptotic proteins and alternative approaches to targeting BCL-2 family interactions.
Here we discuss recent developments in three areas that are fundamental to pathological hypertrophic growth of cardiac myocytes.
Here , we discuss recent findings showing that splicing is misregulated with age.
Here , we discuss related questions on the molecular , cellular , and population level.
Here we discuss some key features of senescence effectors and attempt to functionally link them when it is possible.
Here , we discuss some of the implications of these observations.
Here we discuss that the mTOR pathway can cause cellular pseudo-hypoxic state , manifested by HIF-1 expression and lactate production under normoxia.
Here , we discuss the biology of DNMT3A and its role in controlling hematopoietic stem cell fate decisions.
Here , we discuss the cardioprotective effects of Sirt1 and possible underlying mechanisms.
Here , we discuss the current pharmacotherapy of BPH.
Here we discuss the current state of biomarker discovery for platforms relevant to PDBP.
Here , we discuss the current understanding of the mechanisms of mitochondrial dynamics and their role in cellular and organismal metabolism.
Here , we discuss the data supporting the effects of caffeine in AD , focusing on adenosine A2A receptors and epigenetic modulation of gene expression.
Here we discuss the different microscopy-based , biochemical and genetic methods currently available to study autophagy in various tissues of the popular model Drosophila.
Here , we discuss the effects of space radiation , microgravity , and a combination of these two factors on oxidative stress.
Here , we discuss the emerging roles of senescent cells in renal development , homeostasis , and pathology.
Here , we discuss the genesis of the trans-NIH group and the most salient activities that have occurred in the last @number@ years.
Here we discuss the implications and remaining questions in light of our published findings and new observations.
Here we discuss the interplay between the circadian clock and metabolism , the importance of the microbiome , and how they relate to aging.
Here we discuss the key role of a leaky blood-brain barrier ( BBB ) that accompanies the development of brain metastases.
Here we discuss the mechanisms by which long-lasting elevations in pro-inflammatory cytokines in the hippocampus produce memory impairments.
Here we discuss the potential involvement of Nox4 in mitochondrial oxidative stress and aging in the heart.
Here we discuss the role played by the immune system in preventing and controlling cancer and how aging may retard these anti-cancer mechanisms.
Here , we discuss the strategies to translate discoveries from aging research into drugs.
Here we discuss the various components of the cellular response to DNA damage.
Here we discuss whether the discrepancies in different studies are merely methodological or inherently related to individual differences in responsiveness to the drug.
Here we dissect this theory by comparing changes occurring to B-cells during healthy aging to the ones occurring during chronic immune activation in younger individuals.
Here , we elucidated if SIRT1 regulates TERT expression via transcriptional , epigenetic and post-transcriptional mechanisms.
Here , we employed metabolomics to determine the serum metabolites in the baseline associated with an increased risk of PD.
Here , we employed PARL-based proteomics to define its substrate spectrum.
Here , we employed targeted proteomic profiling of @number@ glycoprotein biomarker candidates across plasma samples of a well-annotated patient cohort with comprehensive CRC characteristics.
Here , we engineered murine MSCs to express sFlt1 and examined the anti-tumor effect of MSC- sFlt1 in combination with continues low-dose doxorubicin treatment.
Here , we established that elevated miR-520c-3p represses global translation , cell proliferation and initiates premature senescence in HeLa and DLBCL cells.
Here we established the role of the developmental transcription factor SOX17 in regulating the bilineage conversion of fibroblasts by the generation of intermediate progenitors.
Here , we establish SIRT4 as a cellular lipoamidase that regulates the pyruvate dehydrogenase complex ( PDH ) .
Here , we evaluated renal function , complications , and physical and mental performance of living kidney donors.
Here , we evaluated the effects of early-life IQ on mental and physical health outcomes at age @number@ in the context of effects of SES.
Here , we evaluated the effects of GSIs and GSMs on a number of neuronal phenotypes possibly relevant to their use in treatment of AD.
Here we evaluated the feasibility , safety and potential efficacy of autologous transplantation of mesenchymal stem cells in subjects with chronic complete SCI.
Here , we evaluated the hypothesis that amplitude of these occipital sources is related to neurodegeneration in occipital lobe as measured by magnetic resonance imaging.
Here , we evaluated the relation between emotional state and asymmetry in PFC activity at rest by using near-infrared spectroscopy ( NIRS ) .
Here , we evaluated the role of Beclin-1 in human osteosarcoma cell lines in vivo and in vitro.
Here we evaluated these data in Japanese community-dwelling elderly.
Here we evaluated whether insulin-related variables contribute to the variance in cognitive performance among individuals with type @number@ diabetes.
Here , we evaluated whether the in-situ environment would affect the angiogenic potential of MSCs.
Here we evaluate sociodemographic predictors of TMD incidence in a community-based prospective cohort study of U.S. adults.
Here we evaluate the anti-tumor efficacy of a human monoclonal antibody against PAUF , PMAb83 , to provide a therapeutic intervention to treat the disease.
Here we evaluate the association between anemia and falls in community-dwelling people aged @number@ years and older.
Here we evaluate the association between DBI and functional outcomes in Health , Aging and Body Composition study participants over @number@ years.
Here , we evaluate the effect of Adipo on Tcad protein expression.
Here we evaluate the trafficking capability of SAP97 in Alzheimer disease ( AD ) patients ' brain.
Here we evaluate whether the difficulty of the walking task matters as well.
Here we examine associations of these traits with @number@ gene regions encoding known antihypertensive drug targets.
Here , we examine changes in resting-state brain function in humans from the Baltimore Longitudinal Study of Aging.
Here , we examined age-related differences in spatial attention by comparing healthy older and younger adults.
Here we examined basic sensorimotor and postural control under different sensory and attentional dual-task demands.
Here , we examined both feedback-based associative learning and generalization in younger , middle-aged , and older adults using a computerized acquired equivalence task.
Here we examined how influenza virus vaccination boosted CD4 T cell responses in younger versus aged humans.
Here , we examined if Aβ deposition in clinically normal adults was related to differences in neural activity in ventral visual cortex during face viewing.
Here , we examined phenotypes of Drosophila melanogaster homologues genes of the human Gaucher's disease gene by using Minos insertion.
Here , we examined structural connectivity based on diffusion tensor imaging ( DTI ) in @number@ participants between @number@ and @number@ years of age.
Here , we examined the 1-year WMI changes in @number@ subjects to clarify long-term effects on the WMI.
Here , we examined the attentional demands of reactive stepping using a well-validated measure of choice stepping reaction time under dual-task interference.
Here , we examined the changes in gene expressions and promoter activities of WRN helicase and telomerase after Rsv treatment.
Here , we examined the clinical course of pediatric and adult PAs with progression at a single institution.
Here , we examined the cross-sectional interrelationships of mitochondrial DNA copy number ( mtDNACN ) and inflammation and their interaction with physical functioning.
Here , we examined the effect of cueing foreign vocabulary during sleep on oscillatory activity during subsequent recognition testing after sleep.
Here , we examined the functional correlation of HSP72 , CHIP , and BAG2 , employing human primary fibroblasts.
Here , we examined the generalization across time within individuals and across different individuals.
Here , we examined the relationship among cerebral autoregulation , small vessel cerebrovascular disease , and amyloid deposition in @number@ non-demented older adults.
Here , we examined whether and how quercetin or Q3GA regulates neural stem cells ( NSCs ) in vivo and in vitro.
Here , we examined whether functional connectivity amongst MTL and cortical regions might better explain differences in subsequent recognition success.
Here we examined whether nuclear lamins are important for a cellular antioxidant mechanism , and whether progerin compromises it.
Here we examined whether VASH1 plays any role in cancer metastasis.
Here , we examine how β-cell [ Ca
Here , we examine RC survival by insurance type.
Here we examine some of the current literature , identify knowledge gaps , and suggest potential research questions regarding acute kidney injury in older adults.
Here , we examine survival for patients with CLL and CML in the United States ( US ) and England.
Here , we examine the association of midlife PA to late-life cognitive function and dementia.
Here we examine the contrast requirement for letter recognition and its relationship with retinal thickness in the macular region.
Here , we examine the contribution of HR factors in promoting MiDAS in human cells.
Here we examine the emergence of object-related responses to an @percent@ harmonic mistuning in infants between @number@ and @number@ months of age.
Here , we examine the evidence that PART has a pathogenic mechanism and a prognosis which differ from those of AD.
Here we examine the neuroprotective effects of Neuropep-1 on several in vitro neurotoxic insults , and triple-transgenic AD mouse model ( 3xTg-AD ) .
Here , we examine the potential of this -980C / G polymorphism to affect APH-1A transcription and confer a risk of AD.
Here we examine the role of inflammation in mediating the relationship between multimorbidity and disability.
Here we examine this association in an adolescent population sample of Australian twins and siblings ( N = @number@ ) aged @number@ to @number@ years.
Here , we examine to what degree this factor is also responsible for age differences in working memory.
Here we examine whether the perceptual system is preferentially tuned to differences among young adult faces.
Here we examine whether this pattern is detectable in 5-year-old children from the healthy population.
Here , we exploit high quality RNA from frozen sIBM muscle biopsies for transcriptomic studies on TDP43-proteinopathy patient tissue.
Here we explored age-related differences when spatial selection is not possible and feature-selective attention must be deployed.
Here we explored patterns of age-related frontal brain activations under multiple task performance conditions and their relationship to white matter ( WM ) microstructure.
Here , we explored phenotypes at birth that are associated with Alu methylation levels in young people.
Here we explored the consequences of specific HDAC5 inhibition in cancer cells.
Here we explored the role of DNMT1 in human skin fibroblasts senescence and its related regulatory mechanisms.
Here , we explored the role of high circulating FSH in physiological endometrial atrophy.
Here we explored the role of one of its homologs , the sortilin-related VPS10 domain containing receptor @number@ ( SORCS1 ) , in AD.
Here we explored the role of oxidative stress in the pathogenesis of this rare cutaneous disease.
Here , we explored the role of the conserved Hippo signaling pathway that serves to maintain optimal size across organs and species.
Here we explored the roles of LRP5 in interleukin 1β ( IL-1β ) - or Wnt-mediated osteoarthritic ( OA ) cartilage destruction in mice.
Here we explored whether expression of NFκB and susceptibility to inhibitor-induced eryptosis is sensitive to erythrocyte age.
Here , we explored whether subcutaneous administration of FGF2 could have therapeutic effects in the APP @number@ transgenic mouse , a model of amyloid pathology.
Here , we explore in particular how this controversy is structured around the founding principles of the sciences of aging.
Here we explore mcDESPOT performance under different experimental conditions to better understand the method's sensitivity and reliability.
Here we explore the potential use of a new method for assessment of protein requirements based on changes in appendicular muscle mass during weight loss.
Here , we explore whether modulation of sRAGE N-glycoform impacts its bioactivity and augments its therapeutic efficacy.
Here , we extended these findings and evaluated MMP-9 expression in postmortem brain tissues of human CAA cases.
Here , we extensively characterized aging-altered gene expression changes across ten human brain regions from @number@ individuals ranging in age from @number@ to @number@ years.
Here , we find that central application of IL-6 in mice suppresses feeding and improves glucose tolerance.
Here we find that Subdued , a calcium-activated chloride channel of the Drosophila anoctamin family , functions in conjunction with the thermo-TRPs in thermal nociception.
Here , we first describe and define the concept of neuroadaptation according to emerging theories based on the growing literature in aging-related cognitive functioning.
Here , we first describe the functions of Mgs1 in DNA transaction.
Here , we focused on Claudin @number@ ( CLDN8 ) , a protein constituting tight junctions in cell membranes.
Here , we focused on the effects of CR at the functional network level.
Here , we focus on and discuss the functional and regulatory network of SASPs toward opening up new possibilities for controlling aging and aging-associated diseases.
Here , we focus on damage associated molecular patterns or DAMPs as a potentially important nexus in the context of this lethal alliance.
Here we focus on preferences for patients ' characteristics ( medical aspects , lifestyle and socio-economic status ) as possible criteria for prioritizing medical services.
Here , we focus on recent progress in the use of small molecules in stem cell biology and regenerative medicine.
Here , we focus on the involvement of chaperone-mediated autophagy ( CMA ) , a selective form of autophagy in the clearance of Htt.
Here we focus on the redox-sensitive signaling components that control the expression of MMP-1 , which is largely responsible for maintaining ECM homeostasis.
Here , we focus on the sirtuins , the mammalian homologs of the yeast life-span-extending molecule , Sir2.
Here we followed telomere length dynamics over a 12-month interval , in divers exposed to intense hyperbaric oxygen in comparison with an age-matched control group.
Here , we found that after separation from their physiological microenvironment , human foreskin-derived SKPs ( hSKPs ) quickly senesced and lost their self-renewal ability.
Here , we found that SIRT6 was predominantly expressed in neuronal cells throughout the entire brain.
Here , we found that the endogenous p53 isoforms Δ133p53 and p53β are physiological regulators of proliferation and senescence in human T lymphocytes in vivo.
Here , we found that the level of microRNA-188 ( miR-188 ) is markedly higher in BMSCs from aged compared with young mice and humans.
Here , we further confirm the association of TREM2 mutations with FTD-like phenotypes by reporting the first compound heterozygous mutation in a Turkish family.
Here , we further demonstrate that depletion of AUF1 abolishes the global interaction of miRNAs and AGO2.
Here , we further examined the effects of FDP on skin.
Here we further investigated η-secretase processing of APP using well-characterized cell models of AD.
Here , we generated a genome-scale shRNA library targeting long intergenic noncoding RNAs ( lincRNAs ) in the mouse.
Here , we generated a transgenic marmoset model of the polyQ diseases , showing progressive neurological symptoms including motor impairment.
Here , we generated Psen1 knockin ( KI ) mice carrying the FAD mutation L435F or C410Y.
Here we generated two mouse models of Atm- and Trp53-deficient CLL.
Here , we genotyped the repeat at C9ORF72 in a large Irish psychosis case-control sample ( n = @number@ ) .
Here , we give an outline of this disease and introduce its diagnosis and treatment.
Here , we give an overview of ageing-related changes in neurogenesis in the brain of humans and rodents.
Here we give an overview of the importance of autophagy in brain aging and in age-related neurodegeneration.
Here we give an overview of the past and ongoing research in the biology of ageing in Spain.
Here we have analyzed the effect of age on LPS-treated monocyte-derived DCs ( MDDCs ) .
Here we have determined the structures of human MAD2L2 in complex with a CAMP fragment in two crystal forms.
Here we have examined the role of GPRC5C in the regulation of insulin secretion and β-cell survival and proliferation using human and mouse pancreatic islets.
Here , we have further investigated this phenomenon by analyzing respiratory chain complex subunits individually.
Here , we have identified an antiterminating homozygous germline mutation in MDM2 in a patient affected by a segmental progeroid syndrome.
Here , we have identified a novel tau aggregation inhibitor , PE859.
Here , we have identified a previously unknown RPE lipofuscin component.
Here , we have identified differentially expressed miRNAs in skeletal muscle from young and old rhesus monkeys using RNA sequencing.
Here , we have identified en masse circRNAs binding HuR in human cervical carcinoma HeLa cells.
Here we have investigated the FVB / N mouse strain , which displays premature thymic involution.
Here , we have investigated the role of the p33ING1 tumor suppressor in the regulation of cellular senescence in human primary fibroblasts.
Here , we have investigated the transcriptional regulation of a cancer associated long non-coding RNA ( lncRNA ) , HOTAIR , under hypoxic conditions.
Here we have performed biochemical investigations to determine the potential regulation of the human Suv3 ( hSuv3 ) helicase function by inorganic cofactors.
Here we have probed the function of fahd-1 , the nematode homolog of FAHD1 , in the context of an intact organism.
Here , we have reviewed microRNA molecules related to the ageing of bones and studies that investigated age-related bone tissue gene expression.
Here , we have reviewed some of the most recent findings on ghrelin and its signalling in animals and humans.
Here we have selected icariin to draw a prototypic network of icariin activities.
Here we have shown that TIF1γ was a tumor suppressor in mouse and human chronic myelomonocytic leukemia ( CMML ) .
Here we have undertaken an attempt to replicate the association of these loci in FTLD cohorts of British origin.
Here , we highlight examples of S-nitrosylated proteins that regulate misfolded protein accumulation and mitochondrial dynamics.
Here we highlight some of the important connections between developmental neurobiology and cancer biology in retinoblastoma.
Here , we highlight the accumulating evidence suggesting that autophagy plays a critical role in the homeostasis of podocytes during glomerular disease and aging.
Here , we hypothesized that RER1 might also play an important role in retention / retrieval of αSyn and mediate levels.
Here , we identified ACOT7 mRNA as a novel target of human WIG1.
Here , we identified a critical role of long intergenic non-protein coding RNA @number@ ( LINC00858 ) in NSCLC.
Here , we identified a known miRNA , miR-339-5p , as a key contributor to this regulatory network.
Here we identified and characterized Drosophila Ataxin-7 and found that reduction of Ataxin-7 protein results in loss of components from the SAGA complex.
Here , we identified androgen-responsive miRNAs by the short RNA sequencing analysis in LNCaP prostate cancer cells.
Here , we identified an HT4 epitope on LRR13 located close to the TLR4 dimerization interface that plays a role in NFκB activation.
Here we identified HMGB1 as a novel metformin-binding protein by affinity purification using a biotinylated metformin analogue.
Here we identified mutations located deep in introns of POLR3A to be a frequent cause of hereditary spastic paraplegia and cerebellar ataxia.
Here we identified @number@ predicted truncation and @number@ missense mutations in @number@ children with rolandic epilepsy ( @number@ of @number@ ) .
Here , we identified palmitoylation of gephyrin as an important mechanism of strengthening GABAergic synaptic transmission , which is regulated by GABAAR activity.
Here we identify a G-rich sequence within the proximal promoter region of vegfr-2 , able to form an antiparallel G-quadruplex ( G4 ) structure.
Here , we identify a new substrate of TRIM32 and propose a mechanism through which TRIM32 might regulate apoptosis.
Here , we identify FOXO4 as a pivot in senescent cell viability.
Here we identify GDF11 as a potent regulator of bone homeostasis.
Here , we identify lysine acetylation as a novel post-translational modification controlling TDP-43 function and aggregation.
Here , we identify MEF2 transcription factors as crucial regulators of sprouting angiogenesis directly downstream from VEGFA.
Here , we identify PLK1 as a physical MTORC1 interactor in human cancer cells.
Here , we identify RNF126 as a ubiquitin ligase that is recruited to DSBs and ubiquitylates Ku80 , with UBE2D3 serving as an E2 enzyme.
Here , we identify the BEN domain-containing protein @number@ ( BEND3 ) as an interaction partner of PICH in human cells in mitosis.
Here we identify the deleted in breast cancer @number@ ( DBC1 ) protein as a key regulator of fat storage capacity of adipocytes.
Here we identify the metalloprotease SPRTN as the DPC protease acting in metazoans.
Here , we identify WRAP53β as an essential regulator of DNA double-strand break ( DSB ) repair.
Here we illustrate those capabilities utilizing a dataset on heart disease , including diagnostic parameters routinely available to physicians.
Here , we initiate an effort to identify nutraceuticals-safer , naturally-occurring compounds-that mimic the anti-aging effects of metformin and rapamycin without adverse effects.
Here , we introduce a hybrid approach to model blood flow at larger scale in the brain microcirculation , based on its multiscale architecture.
Here we introduce a multivariate framework for characterising longitudinal changes in structural MRI using dynamical systems.
Here , we introduce a view of integrative physiology to understand pro-inflammatory cytokines in the control of energy expenditure.
Here , we introduce the Everyday Competence Questionnaire ( ECQ ) , designed to assess healthy older adults ' everyday competence.
Here , we investigated age effects on different mechanisms of saccadic plasticity.
Here we investigated BACE1-mediated cleavage of human contactin-2 , a GPI-anchored cell adhesion molecule.
Here , we investigated changes in glucose and lipid homeostasis with age in PGKBP3 and PGKmutBP3 mice compared with wild-type mice.
Here , we investigated differences in these regions during adolescence and young adulthood.
Here , we investigated effects of feature-based interference from distractor objects that appear in unattended regions of the visual field with a hemifield-tracking task.
Here we investigated face recognition as an ability that may mature late relative to other abilities.
Here , we investigated functional and structural changes in lipoproteins after consumption of policosanol.
Here , we investigated how wounding and intercellular junction formation control successful viral entry.
Here we investigated local structural differences in the hippocampi and amygdalae of elderly schizophrenia patients compared with healthy elderly subjects.
Here , we investigated regulation of CCN1 expression by retinoids in skin equivalent cultures and chronologically aged and photoaged human skin in vivo.
Here , we investigated sex-specific determinants for facial wrinkles.
Here , we investigated similarities and differences in functional brain correlates for associative and item memory as a function of encoding instruction.
Here we investigated the aspirin's antineoplastic molecular route by targeting SHH / GLI1 pathway and examined the feasibility of aspirin combined with TMZ therapy.
Here , we investigated the association between common genetic variants at the 7p21 locus and risk of the neurodegenerative disease frontotemporal lobar degeneration.
Here , we investigated the autophagic function and response to chronic oxidative stress in TM cells isolated from glaucomatous and age-matched donor eyes.
Here we investigated the behavioral and neural determinants of bimanual coordination in aging.
Here , we investigated the combined effect of APOE and BDNF on hippocampal activation ( N = 151 ) .
Here , we investigated the effect of ALA on hepatic FGF21 expression.
Here , we investigated the effect of ApoE ε4 allele on survival in a sample of the healthiest and long-lived Danes.
Here , we investigated the effect of H2 on mitochondria in cultured human neuroblastoma SH-SY5Y cells.
Here we investigated the effects of age on patterns of emotional dominance during binocular rivalry.
Here , we investigated the effects of factors secreted from senescent fibroblasts on stem cells.
Here , we investigated the effects of the MR agonist fludrocortisone on memory in young and elderly healthy individuals.
Here , we investigated the gut compositional changes of Bifidobacterium species over a wide range of ages.
Here , we investigated the impact of ischemic SVD on rapid-onset cortical plasticity , as induced with a paired-associative stimulation protocol.
Here , we investigated the long-term consequences of abnormal ureagenesis in female mice heterozygous ( Het ) for a null mutation in the OTC gene.
Here we investigated the molecular mechanisms that underlie acquired resistance to BRAFi and to the combined therapy.
Here , we investigated the ocular surfaces and lacrimal glands of aged mice of both sexes.
Here , we investigated the protective effect of SR against oxidative stress in dermal fibroblasts.
Here , we investigated the relationship between structural and functional brain senescence and speech perception skills in aging.
Here , we investigated the relationship between the autophagy and hedgehog ( HH ) signaling pathways in gastric adenocarcinoma.
Here , we investigated the role of age in encoding and perceptual processing of stimulus onset visually evoked potentials ( SO-VEPs ) .
Here , we investigated these components contributing to the observed variability in force control in groups of participants differing in age and expertise level.
Here , we investigated the signaling pathways underlying the regulatory functions of telomerase in osteoblastic cells.
Here , we investigated the significance and molecular mechanisms of microRNA-22 ( miR-22 ) governing EPC senescence.
Here , we investigated whether aging alters inflammatory responses during systemic viral infection and thereby contributes to virus-induced death.
Here , we investigated whether changes in glycosylation during the process to senescence may have functional effects on fibroblasts.
Here , we investigated whether Lithium is effective in reducing the inflammatory responses in DCs from the elderly.
Here , we investigated whether LLFS families with EC may also exhibit more favorable profiles of other age-related biomarkers.
Here , we investigated whether speech cues indicating a subsequent change in target speaker reduce the costs of switching in younger and older adults.
Here we investigated whether this effect is similar in two groups of younger and older listeners with normal hearing.
Here , we investigate genetic-determinants in HBsAg correlated with HBV-induced hepatocellular carcinoma ( HCC ) , and their impact on HBsAg-secretion and cell-proliferation.
Here , we investigate heterozygous With rapid aging , many of the elderly suffer from poverty and high healthcare needs.
Here we investigate the cellular processes involved in this response.
Here we investigate the developmental and physiological functions of Ing2 through targeted germline disruption.
Here we investigate the epigenetic mechanism of Klotho deficiency and its functional relevance in renal fibrogenesis.
Here , we investigate the mechanistic connection between SIRT3 and energy homeostasis.
Here , we investigate the possible involvement of BRI2 in human AD pathogenesis.
Here we investigate the relationship between chemical properties of primary and atmospherically aged wood combustion particles and acute toxicity in human airway epithelial cells.
Here , we investigate the role of Notch signaling in HPV and hypoxia-induced enhancement of SOCE.
Here we investigate the transcriptional regulation of the human Lsh promoter.
Here we investigate transcriptomic changes associated with this impaired adaptive response.
Here we investigate two types of interactions between expression and threat contexts.
Here we investigate whether cognitive decline is affected by interaction between these two risk factors.
Here we investigate whether glycans derived from the total glycoprotein pool in plasma mark familial longevity and distinguish healthy from unhealthy aging.
Here we investigate whether N-linked glycans reflect early features of human longevity.
Here , we investigate whether this pathway overall associates to longevity , and whether specific sub-processes are more strongly associated with longevity than others.
Here we isolated habitual attention from context processing in young and older adults.
Here we look at the use of sensory information in young and middle-aged participants using a locomotor-driven interceptive task.
Here , we measure the biomarker potential of circulatory miRNAs in aging and various aging-related pathologies.
Here , we observe that NK cells are less activated following DC vaccination.
Here , we offer evidence that stereotype threat consumes working memory resources in older adults.
Here , we optimized the episodic face-name paired-associates task in order to test the functioning of the hippocampus in normal aging.
Here we outline strategies on the generation of an AAV vector expressing the mitochondria-targeted catalase gene ( AV.RSV.MCAT ) .
Here we outline the current guidelines for AAA management and discuss modern scientific techniques currently employed to identify improved diagnostic and prognostic markers.
Here we outline the project's goals , history , and main findings since its inception in @number@
Here we performed a high-throughput chemical screen for agents that could alleviate the cellular sensitivity of NER-deficient cells to UV-induced DNA damage.
Here we postulated that calcium may enable or accelerate the aggregation of Aβ.
Here , we present a case of an 82-year-old female Caucasian patient with wet age-related macular degeneration.
Here , we present a combined probe head for simultaneous , time-saving NIR spectroscopy and skin impedance measurements.
Here we present a concept that considers organism aging as an additional facultative function promoting evolution , but counterproductive for an individual.
Here we present a database MitProNet which provides a comprehensive knowledgebase for mitochondrial proteome , interactome and human diseases.
Here , we present a detailed protocol to establish and validate the assay.
Here we present a generic metabolic transformation algorithm ( MTA ) addressing this issue.
Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to @number@ adult samples from @number@ cohorts.
Here , we present a method for cataloging mutations in individual human ASCs without the necessity of using error-prone whole-genome amplification.
Here , we present a method that allows testing excitability of different fractions of the corticospinal transmission.
Here we present a method to distinguish between error and telomere elongation in longitudinal datasets , which is easy to apply and has few assumptions.
Here , we present a model linking genome-wide changes and their age-related phenotypic consequences via the alteration of macromolecular complexes and cellular networks.
Here we present an age-prediction tool for whole blood based on massive parallel sequencing ( MPS ) and a random forest machine learning algorithm.
Here , we present and validate a fully automatic technique for segmentation and volumetric quantification of WMHs in aging and AD.
Here , we present an easy-to-use computational toolkit for ion-binding state analysis , called IBiSA tools.
Here , we present a new application for testing human cerebellum-dependent motor learning using prism adaptation.
Here , we present a new way to precisely quantify and identify senescent cells in tissues on a single-cell basis.
Here , we present an optimized approach for the isolation of pure myenteric plexus ( MP ) from adult mouse and human.
Here we present a novel computational model to reproduce the probability of glioma incidence across the lifespan.
Here , we present an overview on the molecular mechanisms by which these interventions mediate lifespan extension in yeast.
Here we present a promising alternative therapeutic strategy for ALS that involves targeting ataxin-2.
Here , we present a relatively novel approach of examining the relationship between memory performance and glutamate-glutamine levels using short echo time magnetic resonance spectroscopy.
Here , we present a summary of data obtained on DNA damage and its implication in muscle homeostasis , myogenic differentiation and neuromuscular disorders.
Here , we present convergent evidence from @number@ online participants and a comprehensive analysis of normative data from standardized IQ and memory tests.
Here , we present correlations between peripheral T-cell phenotypes and 8-year survival in individuals from the population-based prospective Leiden 85-plus Study.
Here , we present data suggesting a negative regulatory function in mitochondrial transcription or transcript stability.
Here , we present data supporting the competition of Nogo- and MHCI-mediated inhibition where they coexist.
Here , we present DrugAge ( @url@ , a curated database of lifespan-extending drugs and compounds.
Here , we present evidence demonstrating that fibrin deposition increases in the AD brain and correlates with the degree of pathology.
Here , we present evidence for the hypothesis that corneal epithelial cells function as glial cells to support the ICNs.
Here we present for the first time a minimally invasive surgical technique for a simultaneous mid-face and eyebrow lift using one small temporal incision.
Here we present gene expression profiles of purified microglia isolated at autopsy from the parietal cortex of @number@ human subjects with intact cognition.
Here we present how data derived from a sensor-based in-home monitoring system may be able to be used to provide a measure of neurological health.
Here , we present its updated version , named NeuroChip.
Here we present new evidence showing that sustained stress granule formation triggers RBP aggregation.
Here , we present novel meta-analyses of freely-accessible molecular network and gene ontology annotation information resources for S. aureus omics data interpretation.
Here we present @number@ Italian family with MSA and prion disease.
Here , we present @number@ new cases and review the literature.
Here , we present @number@ studies.
Here we present our analysis plan and our reservations concerning GWIS.
Here we present regulation of mitochondrial translation by the Mitochondrial Translation Optimization Factor @number@ MTO1 , as a novel player in this scenario.
Here we present results of two integrated studies.
Here we present simple , accurate and cost-efficient techniques for estimation of human biological age , Male and Female Arterial Indices.
Here , we present the case of an immunocompromised 59-year-old male with surgical history of a pancreatic pseudocyst stented endoscopically.
Here we present the case of RG3487 , a molecule which induced FAH and , later on , tumors in rats.
Here , we present the crystal structure of human TopIIIα complexed to the first oligonucleotide-binding domain ( OB fold ) of RMI1.
Here we present the current mechanistic understanding of this process and the evidence for profound changes in chromatin dynamics during aging.
Here we present the current status of polysaccharides in anti-aging and anti-neurodegenerative studies.
Here , we present the first empirical investigation of vigilant attention to verbal stimuli in healthy normal aging.
Here , we present the result of phosphoproteomic analyses of cow and rat glomeruli to allow cross-species comparisons.
Here , we present the results of a large-scale proteome analysis to determine protein partners of WRN.
Here we present the results of a longitudinal , combined fMRI-DTI study in cognitive normal ( CN ) older adults.
Here , we present these mechanisms providing , also , the necessary background related to the morphology and various characteristics of the BBB.
Here , we present transcriptional regulatory networks ( TRNs ) that control cellular processes related to the SSC-to-mSSC reprogramming.
Here we present Zmpste24 mosaic mice that lack these limitations.
Here we propose a chemiluminescence ( CL ) -based method for the sensitive detection of telomere DNA in human cells.
Here we propose a method based on non-linear image registration to estimate and analyze from observed brain morphologies the relative contributions from aging and pathology.
Here , we propose a new definition of approximate and sample entropy based on the inhomogeneous point-process theory.
Here , we propose a novel Network Ontology Analysis ( NOA ) method to perform gene ontology enrichment analysis on biological networks.
Here , we propose a selective multi-hit model of photoaging.
Here we propose , for the first time , vascular activation as a relevant mechanism in AD pathogenesis.
Here we propose , in a hypothesis piece , that aging can influence the physiopathology of CRS and its subsequent management in an elderly population.
Here we propose that evolutionary forces can help explain this paradox.
Here , we propose that immunosurveillance is a key regulator of tissue homeostasis.
Here , we propose that the life span extension produced by caloric restriction can be duplicated by the metabolic changes induced by ketosis.
Here , we propose that the normal decline in oxidative metabolism during aging constitutes an early and important \ "hit \ " that drives tumorigenesis.
Here , we propose the self-reporting Functional Ability Index ( FA index ) suitable to screen functional competence in senior citizens in the community setting.
Here we provide a background to this project , discussing the history of the comet assay and practical issues that can critically affect its performance.
Here , we provide a brief overview of how flies can be used to analyze molecular mechanisms underlying human neurodegenerative diseases.
Here , we provide a brief overview of the main mechanisms involved in AD , some of which may be epigenetically modulated by bioactive food.
Here , we provide a brief overview on the relevance of anorexia in the context of sarcopenia and frailty.
Here , we provide a description of the existing databases and computational tools on ageing that are available for researchers.
Here , we provide a direct quantitative comparison of amyloid plaque burdens and plaque sizes in four lines of AβPP transgenic mice.
Here , we provide a historical background and highlight the combined clinical , pathologic and morphometric evidence related to ASYMAD.
Here , we provide an evolutionary perspective on fibrosis aimed at elucidating its etiopathogenesis.
Here we provide an overview about effect of these aggregates on the proteasomal system , followed by transcription factor activation and loss of cell viability.
Here , we provide an overview of the roles of apoptosis and cellular senescence in cancer and aging.
Here , we provide a perspective by defining the problem and analyzing the possible causes and consequences.
Here , we provide a review of normal skeletal muscle vasculature with details of the ultrastructure of vessel walls.
Here , we provide a snapshot of some of the main findings in @number@
Here we provide evidence for the involvement of p53-CBP axis in apoptosis through Puma / Noxa induction , in response to β-adrenoceptor activation.
Here we provide evidence of an analogous layered immune system in humans.
Here we provide evidence that BCAA catabolism is involved in human breast cancer.
Here , we provide evidence that CALM also influences the cell surface level of the AMPA receptor subunit GluR2.
Here , we provide evidence that Lamin A / C is silenced via this mechanism in a subset of neuroblastoma cells.
Here we provide evidence that neural computations in the right temporoparietal junction ( rTPJ ) and interconnected structures are causally involved in this process.
Here we provide general methods to purify lipid microdomain proteins and to discriminate cell surface lipid microdomains-associated glycohydrolases from those not exposed on cell surface.
Here , we provide insights into S100A9 specific mechanisms of action in Alzheimer's disease ( AD ) .
Here , we provide practical tips , and review techniques and outcomes of TM bypass and ablation MIGS.
Here , we provide snapshots of the evolving microbial-host associations and relations during distinct milestones across the lifespan of a human being.
Here , we pursue a targeted analysis of the TREM locus in relation to cognitive decline and pathological features of AD.
Here , we quantified daily physical activities in a large cohort of PD patients and another large cohort of matched controls.
Here , we quantified the cortical pattern and age-related changes of thalamocortical connections by using probabilistic tractography in children and adolescents.
Here , we quested for the answer particularly focusing on mitochondrial homeostasis and O-GlcNAcylation in rat retina.
Here , we questioned whether T cell responses directed against the highly conserved HLA-A2-restricted M158-66 peptide of IAV evolves with increasing age.
Here we recorded saccade performance in @number@ patients with PD and @number@ age-matched controls , and studied how the abnormality changed with disease progression.
Here we related 15-year changes in episodic memory to 4-year changes in cortical and subcortical gray matter volume and in white-matter connectivity and lesions.
Here , we report a 33-year-old Greek female with phenotype suggestive of NHD.
Here , we report a 5-year follow-up to determine the magnitude of within-person olfactory decline.
Here we report a biomarker validation study of the identified miRNA pairs using larger independent sets of age- and gender- matched plasma samples.
Here , we report a computational study to describe the ligand binding and the experimental antiplatelet profiles of Edaglitazone and Ciglitazone.
Here , we report additional mechanisms for Mieap-regulated MQC.
Here , we report a differential impact of ET on protein quality in young and older participants.
Here , we report a function of SNX27 in regulating β-amyloid ( Aβ ) generation by modulating γ-secretase activity.
Here we report a genome-wide transcriptome analysis of the fungal aging model Podospora anserina.
Here we report a mechanistic link between chronic inflammation and aging microglia and a causal role of aging microglia in neurodegenerative cognitive deficits.
Here we report a mitochondrial metabolic profile assessing short-term ( up to six hours ) and longer-term ( 12-24h ) durations of low-glucose stress.
Here we report an in-depth analysis of pol ν-defective mice and human cells.
Here we report a novel function of JunD in the regulation of microRNA expression in intestinal epithelial cells ( IECs ) .
Here we report a novel pathway by which DRAM1 regulates apoptosis involving BAX and lysosomes.
Here , we report a novel protein involved in kinetochore-microtubule attachment , chromosome alignment-maintaining phosphoprotein ( CAMP ) ( C13orf8 , ZNF828 ) .
Here we report a novel role of miR-155 in cancer metabolism through the up-regulation of thiamine in breast cancer cells.
Here we report a novel-screening assay , for the identification of compounds that block different types of senescence response.
Here we report a phenomenon in the AOPs : induced effects , which is a common property of combustion reaction.
Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis.
Here , we report a proteomic analysis of proteins modified by SUMO2 in response to DNA replication stress in S phase in human cells.
Here we report a role for elevated IL30 in supporting the breast cancer cell viability and invasive migration.
Here we report a spatial-temporal map of plaque load in 5xFAD mouse spinal cord.
Here we report a synergistic cooperation between CDC-48 and ATX-3 ( the Caenorhabditis elegans orthologue of ataxin-3 ) in ubiquitin-mediated proteolysis and ageing regulation.
Here we report a thiol-dependent process that may account for impaired autophagy during aging.
Here , we report a widespread increase in protein turnover in HGPS-derived cells compared to normal cells.
Here we report diagnostic and cognitive findings at the first ( 18-month ) follow-up of the cohort.
Here , we reported that Gadd45a-deficient ( Gadd45a ( - / - ) ) mice showed a normal hematologic phenotype under homeostatic conditions.
Here , we reported that histone H3K27me3 demethylase Jumonji domain containing @number@ ( Jmjd3 ) was essential for M2 microglia polarization.
Here , we reported that level of @number@ hmC was decreased in HCC tissues , as compared with non-tumor tissues.
Here , we report evidence that is consistent with findings from the animal studies.
Here we report evidence to show that AR is a key mediator of inflammatory signals in ESCC cancer progression.
Here , we report FGF overexpression curtails gp120-induced neurotoxicity in a double transgenic mouse model.
Here , we report for the first time the anti-PAK1 activity of compounds derived from three distinct Okinawa plants.
Here we report on a key role of Klotho ( Kl ) , an aging-suppressor gene , in retinal health and RPE physiology.
Here , we report on a new nanotechnology platform capable of rapid and sensitive MV detection in packed red blood cell ( pRBC ) units.
Here , we report on a whole genome analysis of gene expression during dopaminergic differentiation of human ESC / iPSC using Illumina bead microarrays.
Here , we report on data that specifically address macrophage biology / physiology in obesity-induced inflammation and insulin resistance.
Here , we report on the consistent and strong upregulation of CST1 expression during cellular senescence , independent of the initial trigger.
Here we report on the identification of a conserved transcriptomic signature of ageing based on gene expression data from four vertebrate species across four tissues.
Here we report on the training-related effects on neuromuscular function of the plantar flexors.
Here , we report OTUD3 as a deubiquitylase of PTEN.
Here , we report that ADAR1 coordinates with ADAR2 to regulate editing and stability of Ctn RNA.
Here we report that a nonsynonymous single nucleotide polymorphism in SLC29A1 ( rs45458701 ) is responsible for the At ( a- ) blood type.
Here we report that a PINK1-binding mitochondrial protein , PGAM5 , modulates the PINK1 pathway.
Here , we report that brain-specific SIRT6-deficient mice survive but present behavioral defects with major learning impairments by @number@ months of age.
Here we report that BubR1 expression is significantly reduced with natural aging in the mouse brain.
Here , we report that GABA markedly increased circulating levels of Klotho in streptozotocin ( STZ ) -induced diabetes.
Here we report that heterozygous mutant BiP mice revealed motor disabilities in aging.
Here , we report that human ribose-5-phosphate isomerase A ( RPIA ) plays a role in human hepatocellular carcinoma ( HCC ) .
Here , we report that JUN is a target of heat shock transcription factor HSF1.
Here , we report that LC3 is phosphorylated at threonine @number@ ( Thr ( @number@ ) ) by the mammalian Sterile-20 kinases STK3 and STK4.
Here we report that long-term ampakine treatment markedly slows the progression of striatal neuropathology and locomotor dysfunction in the R6 / 2 HD mouse model.
Here , we report that MBS is a negative regulation element and B-MYB binds to this site in vivo.
Here we report that monoamine oxidase A ( MAO-A ) plays pathogenic roles in the comorbidity.
Here we report that NCEH-1 protects dopaminergic neurons from α-synuclein-dependent neurotoxicity in C. elegans via a mechanism that is independent of lifespan extension.
Here we report that one of the translation initiation factors , eIF4E , is phosphorylated by Mammalian Ste20-like kinase ( MST1 ) .
Here we report that over @percent@ of palAPP is dimerized while only ~20% of total APP forms dimers.
Here we report that p53 is translocated to the cytoplasm by androgen-mediated induction of G3BP2 , a newly described direct target gene of AR.
Here , we report that plasminogen stimulates propagation of the protease-resistant scrapie PrP ( PrP ( Sc ) ) .
Here we report that progranulin deficiency leads to increased TMEM106B protein levels in the mouse cortex with aging.
Here , we report that ROCK1 knockdown increased endogenous human Aβ production , whereas ROCK2 knockdown decreased Aβ levels.
Here , we report that runt-related transcription factor ( RUNX1 ) could be a key molecule for the androgen-dependence of prostate cancer.
Here , we report that SFN activates heat shock transcription factor 1-mediated heat shock response.
Here we report that Sir2 was under expressed in human glioma tissues and cell lines.
Here we report that SIRT1 levels rise in prometaphase leading to SIRT1 global association with mitotic chromatin until telophase.
Here , we report that SIRT6 deacetylates lysine @number@ of p53 in short synthetic peptide sequence and in full length p53.
Here , we report that the actions of CCN1 are mediated by induction of interleukin 1β ( IL-1β ) .
Here we report that the central player in HR , RAD51 , is ubiquitylated by the SCF ( FBH1 ) complex.
Here we report that the KCNE2 potassium channel transmembrane regulatory subunit is expressed in human and mouse pancreatic β cells.
Here , we report that the level of CENP-A , a protein required for cell division , declines precipitously with age in an islet-specific manner.
Here , we report that the mitochondrial Sirtuin Sirt4 regulates mitochondrial ATP homeostasis.
Here , we report that THSer ( P ) -31 co-distributes with the Golgi complex and synaptic-like vesicles in rat and human dopaminergic cells.
Here , we report the crystal structure of the TRF1-binding motif of human TERB1 in complex with the TRFH domain of TRF1.
Here , we report the crystal structures of the POMK catalytic domain in the absence and presence of an ATP analogue and O-mannosylated glycopeptide.
Here we report the development of novel murine monoclonal antibodies specific for different G4 DNA structures.
Here we report the extensive molecular characterization of @number@ primary cervical cancers , one of the largest comprehensive genomic studies of cervical cancer to date.
Here we report the first proteome-wide study of carbonylated proteins including modification sites in HeLa cells for mild oxidative stress conditions.
Here we report the first study using base editor ( BE ) system to correct disease mutant in human embryos.
Here we report the formative evaluation of this project.
Here , we report the generation and characterization of mice lacking Neil2 ( Nei-like @number@ ) .
Here we report the generation of a human CSB-knockout cell line.
Here we report the generation of induced pluripotent stem cells ( iPSCs ) from fibroblasts obtained from patients with HGPS.
Here we report the identification of mutations in STX1B , encoding syntaxin-1B , that are associated with both febrile seizures and epilepsy.
Here , we report the identification of @number@ pedigrees of Southern Italian extraction in whom FTD segregates with autosomal dominant inheritance patterns.
Here we report the mechanistic involvement of a unique and previously undescribed subset of regulatory B cells.
Here we report the novel finding that hTDP-43 mice develop deficits in cognition , motor performance , and coordination.
Here we report the novel mechanisms how ALK5 inhibitors exert a therapeutic effect on a mouse B16 melanoma model.
Here we report the novel role of NKAP in splicing.
Here , we report the presence of an enhancer element in surrounding region of rs2279590.
Here we report the results of those experiments.
Here we report the role of Nampt in regulating osteoblast differentiation in primary mouse BM-MSCs.
Here , we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations.
Here , we report the successful generation of human iPSCs in a feeder-independent culture system with defined factors.
Here , we report the synthesis and evaluation of AG11 , a new flavanone derivative obtained through cyclization of its chalcone precursor CB11.
Here we report the transglycation activity of hydralazine using a newly developed MALDI-TOF-MS based assay.
Here , we report the updates of the database , mainly focusing on the following two points.
Here we report two experiments with toddlers exploring whether they can use statistical evidence to infer the subjective nature of preferences.
Here , we report tyrosine phosphorylation of the Hippo pathway tumor suppressor LATS1 as a mechanism underlying its regulation by cell adhesion.
Here , we respond to their main criticisms , concluding that they are not sufficiently supported by the data presented.
Here we reveal a fundamental regularity.
Here , we reveal the role of human Spartan in facilitating replication of DNA-protein crosslink-containing DNA.
Here , we review accumulating evidence supporting a role for epigenetics in the regulation of cartilage homeostasis and OA pathogenesis.
Here we review and compare age-associated changes in murine and human B cell pools and humoral immune responses.
Here , we review a number of recent studies and make suggestions in two critical future research directions.
Here we review brain changes that have been studied with DTI over the human lifespan and findings in a variety of neuropsychiatric disorders.
Here we review brain rejuvenation studies in the broader context of systemic rejuvenation research.
Here we review clinical trials of cognitive training , published during the last five years , and summarized some important characteristics of training tasks design.
Here , we review common patterns of reproduction , focusing on the relationships between reproductive performance , survival and parity in females.
Here we review current knowledge about SIRT1 and ocular aging.
Here we review current understanding of the mechanism by which cells sense damaged and foreign DNA.
Here , we review data that have aided in our understanding of the role of age , sex and steroid sex hormones in radiation cataractogenesis.
Here , we reviewed the current literature on the various interconnected functions of gingival and mucoperiosteal fibroblasts during the repair of oral wounds.
Here we reviewed the recent literature on blood-based biomarkers in AD to provide a current state of the art.
Here we review epigenetic effects of chromosomal aneuploidies , focusing on findings in Down syndrome ( DS , trisomy @number@ ) .
Here we review evidence suggesting that this pathway contributes essential molecules to the biomass of the brain.
Here , we review evidence that intrinsic plasticity is an important and evolutionarily conserved neural correlate of learning.
Here , we review how age-related leptin resistance triggers metabolic disturbances and affects the longevity of obese patients.
Here , we review how C. elegans has been utilized to model Alzheimer's disease.
Here , we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology.
Here we review how sleep is altered in the ICU , with particular attention to older patients , especially those aged ≥80 years.
Here , we review how sterols act through evolutionarily ancient mechanisms to control these processes.
Here , we review known biological theories of aging and how ROS mechanistically control senescence and the aging process.
Here we review mechanisms of redox signaling with an emphasis on redox-active signaling endosomes.
Here , we review mitochondrial protein quality control with a focus on organelle biogenesis and aging.
Here , we review notable findings and the consensus understanding on the biomechanics and microstructure of the posterior eye.
Here , we review @number@ different plant-derived natural compounds , phytochemicals , which have been investigated in experimental animal models of TBI.
Here , we review our current understanding of lncRNAs that control the development of aging traits.
Here we review published studies and present new ideas related to the question of the specificity of synapse loss in AD.
Here we review rapid advances in the genetic understanding of clonal hematopoiesis and nascent evidence implicating clonal hematopoiesis in malignant and non-malignant age-related disease.
Here , we review recent advances in our understanding of mTOR function , regulation , and importance in mammalian physiology.
Here , we review recent data concerning the modern treatment of older HIV-infected adults.
Here , we review recent developments in understanding the pathophysiological implications of peroxisomal dysfunctions outside the context of inherited peroxisomal disorders.
Here , we review recent studies that shed light on the nature and regulation of this evolutionarily conserved secretory program.
Here we review recent studies that support the existence of this link and discuss their implications for understanding mammalian physiology and pathology.
Here , we review several candidate hypotheses and critically review supporting and contesting scientific evidence for the underlying theories.
Here , we review similarities and differences in mechanisms and pathways between RTG genes in yeast and NF-κB as seen in more complex organisms.
Here we review some history of the hypothesis , recent findings , and questions for ongoing research.
Here , we review some of the epigenetic pathways that contribute to cellular senescence and age-associated phenotypes.
Here we review some of the major physiological , psychological , and behavioral changes after @number@ months of CR in overweight otherwise healthy volunteers.
Here , we review some of the mechanisms and signaling pathways involved in the development of the hippocampus , as well as in adult neurogenesis.
Here , we review some of the mitochondrial signaling pathways that participate in establishing cellular senescence.
Here , we review some promising developments that are contributing toward this goal.
Here , we review such recent advances that have widened and , in some cases , deepened our knowledge of DDR signaling.
Here , we review the available assays for measuring somatic mutations , with a focus on recent single-cell , whole genome sequencing methods.
Here we review the available data on endophenotypes of humans and rodents with TBI associated with epilepsy.
Here , we review the biochemistry of the prenyltransferase enzymes and numerous isoprenoid analogs synthesized to investigate various aspects of prenylation and prenyltransferases.
Here , we review the biological and socio-behavioral factors that may contribute to this sex-frailty paradox.
Here we review the cellular and molecular features of an aged immune system and discuss the trade-offs inherent to these adaptive mechanisms.
Here , we review the characteristics of elderly PCNSL patients with a particular focus on advances in the optimization of treatment regimens.
Here we review the circuitry , distinctive functions , and neurotrophin-dependence of the EC that are relevant to its vulnerability.
Here , we review the clinical aspects of AMD and summarize the genes which have been reported to have a positive association with the disease.
Here we review the clinical development of ghrelin and ghrelin mimetics ( also known as growth hormone secretagogues or GHS ) for cancer cachexia treatment.
Here , we review the contribution of mitochondrial DAMPs to inflammation and discuss some of the mechanisms at the basis of their generation.
Here , we review the course and impact of senescence-associated inflammatory responses in aging and cancer.
Here , we review the current evidence regarding neuro-immune interactions in the regulation of neurogenesis under distinct conditions , including aging.
Here , we review the current knowledge on how acute inflammation is intertwined with axonal regeneration , an important component of CNS repair.
Here we review the current knowledge on the mechanism of hepatocytes polyploidization during postnatal growth , aging , and liver diseases.
Here we review the current knowledge on the regulation of mammalian NAD biosynthesis , with focus on the relevant rate-limiting enzymes.
Here we review the current state of knowledge about the red cell storage lesion from a proteomic perspective.
Here we review the current understanding and progression in these areas.
Here , we review the emerging concepts highlighting the putative aging-associated abnormalities involved in some human ILDs.
Here , we review the emerging picture of how nutrient-sensing pathways affect stem cell behavior , providing a mechanism to influence life span.
Here , we review the emerging roles of ubiquitin at mitochondria.
Here we review the evidence for EMT in COPD as well as the current progress being made on understanding the drivers and mechanisms involved.
Here , we review the evidence which indicates that loss of B-MYB expression has an important role in causing senescence growth arrest.
Here we review the evolutionary conservation of the IIS pathway and discuss this in relation to recent findings on the molecular basis of ageing.
Here , we review the evolution of the diagnosis of osteoporosis.
Here , we review the extant literature on this topic.
Here we review the history and medical applications of MB , with emphasis on recent developments.
Here we review the impact of CMV on \ "immune senescence \ " in humans.
Here , we review the implications of these discoveries for understanding emphysema biology as well as for patient care.
Here , we review the importance of chromatin regulation in adult stem cell compartments.
Here , we review the key factors associated with cell cycle and chromatin remodeling to accelerate or delay the MSC aging process.
Here , we review the latest research on the development of Aβ modulators for neuroprotection in AD.
Here we review the limited literature on homeostatic innate immune cell trafficking in ageing in the absence of chronic inflammation.
Here , we review the link between alterations in mitochondrial dynamics , aging , and age-related impairment.
Here , we review the literature on how temperature affects longevity , ageing and life history traits.
Here we review the molecular mechanisms underlying telomere-driven diseases and highlight recent advances in the preclinical development of telomere-targeted therapies using mouse models.
Here , we review the molecular pathways linking aging and reprogramming along with the unanswered questions in the field.
Here , we review the need for an animal model and discuss the suitability of the mouse as an ARHL model.
Here , we review the neural correlates of cognitive control associated with bilingualism.
Here , we review the properties , function , and formation of these compartments.
Here we review the published evidence with respect to the involvement of inflammation and infection in prostate cancer.
Here we review the recent findings to elucidate the important role of p53 in cell metabolism.
Here , we review the recent studies on the soluble oligomers , especially low-n oligomers in Alzheimer's disease.
Here , we review the representative environmental factors known to affect human intellectual development during each developmental stage.
Here , we review the RNA-binding activities of nucleolin , its influence on gene expression patterns , and its impact upon diseases.
Here , we review the role of the nematode in renal research and discuss future perspectives for its use in molecular nephrology.
Here , we review these advances , providing an overview of mTOR signaling and its role in murine and human stem and progenitor cells.
Here , we review these novel studies and discuss the potential of ageing alteration as a therapeutic approach for the treatment of late onset neurodegeneration.
Here we review these recent developments and consider what has been learned about the causes of chromosome missegregation in early development.
Here , we review these recent findings and discuss their implications in the context of stem cell biology , aging research , and regenerative medicine.
Here we review this topic to identify how such changes may improve health at perimenopause and beyond.
Here , we review what is known about the nuclear adaptive compensatory mechanisms induced in response to mitochondrial malfunction.
Here we review what is known about the roles of eIF4G in molecular , cellular , and organismal contexts.
Here , we sequenced exon2 of TREM2 in the northern Han Chinese population consisting of @number@ patients with LOAD and @number@ control subjects.
Here , we shed light on the most important developments in tau radiopharmaceuticals , highlighting challenges , possibilities and future directions.
Here , we show a brain-specific reduction in beclin1 expression in postmortem hippocampus of schizophrenia patients , not detected in peripheral lymphocytes.
Here we show a novel inhibition of PMCA activity by tau which is concentration-dependent.
Here , we show an overall significant reduction in PER2 expression in oral mucosa with aging in the morning , noon , and afternoon.
Here , we show a role for FOXO4 in mediating senescence by the human BRAF ( V600E ) oncogene , which arises commonly in melanoma.
Here , we showed that IGF1R antibody led to rapid cell death and tumor regression in some rhabdomyosarcoma ( RMS ) cells.
Here , we showed that L-OPA1 and cardiolipin ( CL ) cooperate in heterotypic mitochondrial IM fusion.
Here we showed that PMA-induced arrest was followed by conversion to cellular senescence ( geroconversion ) .
Here , we showed that the lack of functional CSB does not represent a barrier to genetic reprogramming.
Here , we show evidence in support of that hypothesis.
Here , we show how the derived factors summarizing pathway expression can be used to analyze the relationships between expression , heritability , and aging.
Here we show that ageing microglial phenotype is largely imposed by interferon type I ( IFN-I ) chronically present in aged brain milieu.
Here we show that aging murine and human beige progenitor cells display a cellular aging , senescence-like phenotype that accounts for their age-dependent failure.
Here we show that a loss of fine-grained visual information associated with age can affect the perception of surface undulations in patterned surfaces.
Here , we show that amino acid uptake by dynamin-dependent endocytosis plays a critical role in mTORC1 activation.
Here we show that antibodies capable to bind α7 ( 1-208 ) are present in the blood of both healthy humans and AD patients.
Here we show that APP / PS1 / AI triple Tg mice have a 2-fold increase of plasma HDL cholesterol levels.
Here , we show that association of COH1 with the Golgi complex depends on the small GTPase RAB6.
Here , we show that astrocytic LRP1 plays a critical role in brain Aβ clearance.
Here , we show that atherogenic response is among the most regulated processes in PPI-treated HCAECs.
Here we show that ATM affects proper bipolar mitotic spindle structure independently of DNA damage.
Here we show that axon regeneration in aging C. elegans motor neurons is inhibited by the conserved insulin / IGF1 receptor DAF-2.
Here , we show that Aβ and gramicidin form aggregates enriched in β-sheet structures using electron microscopy , and Thioflavin and Congo Red staining techniques.
Here we show that both AMPK and calcineurin modulate longevity exclusively through post-translational modification of CRTC-1 , the sole C. elegans CRTC.
Here we show that C1q protein levels dramatically increase in the normal aging mouse and human brain , by as much as 300-fold.
Here , we show that C. elegans RACK-1 has been vital in determining the survival of worms under specific pathogenic infection.
Here we show that chronic damage signals , probably caused by telomere processing , affect expression of histones and lead to their depletion.
Here , we show that ciliary function ( polycystins ) and structure ( polaris ) are required for proper cellular division.
Here , we show that COL17 plays a central role in regulating interfollicular epidermis ( IFE ) proliferation.
Here we show that cytosolic p53 impairs autophagic degradation of damaged mitochondria and facilitates mitochondrial dysfunction and heart failure in mice.
Here we show that deletion of several UPR target genes significantly increases replicative lifespan in yeast.
Here we show that deletion or enzymatic inactivation of lysine-specific demethylase @number@ ( Lsd1 ) triggers senescence in trophoblast stem cells ( TSCs ) .
Here , we show that DLA-M absorbs free fatty acids ( FFA ) and endotoxins in vitro and in vivo.
Here , we show that DRAM is an important gene for the enhancement of p53-dependent apoptosis.
Here , we show that elevated calpain , but not caspase-3 , activity is a prominent feature of AD brain.
Here we show that epigenetic regulator and central transcriptional instructor in adult stem cells , Bmi1 , protects against DCM by repressing cardiac senescence.
Here we show that Escherichia coli cells secret AGEs by the energy-dependent efflux pump systems.
Here , we show that expression of p66Shc , p52Shc , and p46Shc is regulated at the post-transcriptional level by the microRNA let-7a.
Here , we show that GeneOptimizer software program-assisted , reengineered sRAGE cDNA enhances the recombinant protein expression in CHO cells.
Here we show that haploinsufficiency of Akt1 leads to an increase of the lifespan in mice.
Here we show that HIF-1α protects against drug-induced apoptosis by antagonizing the function of the tumor suppressor p53.
Here , we show that higher levels of Caspase-6 activity in the CA1 region of aged human hippocampi correlate with lower cognitive performance.
Here , we show that human ATSCs in which Ago2 was downregulated underwent apoptosis.
Here we show that human cord plasma treatment revitalizes the hippocampus and improves cognitive function in aged mice.
Here , we show that human mismatch recognizing proteins MutS homolog @number@ ( MSH2 ) and MSH6 copurify and interact with replicative Pol α.
Here , we show that , in addition , α-catenin forms complexes with nesprin-2 that include β-catenin and emerin.
Here , we show that individual dermal fibroblasts also exhibit a significant increase in stiffness during aging in vivo.
Here we show that inhibition of the Tie2 ligand angiopoietin-2 ( Ang2 ) effectively blocks metastatic growth in preclinical mouse models of postsurgical adjuvant therapy.
Here , we show that in p21 @number@'UTR , NSUN2 catalyzes m5C modification and METTL3 / METTL14 catalyzes m6A modification.
Here , we show that klotho is a key factor underlying the neuroprotective effect of latanoprost during post-axotomy retinal ganglion cell ( RGC ) degeneration.
Here , we show that LRP1 interacts with and regulates the cellular distribution and turnover of GluA1.
Here we show that macrophages at sites of muscle injury induce activation of satellite cells via expression of Adamts1.
Here , we show that maintenance of continuous presynaptic SNARE-complex assembly required a nonclassical chaperone activity mediated by synucleins.
Here , we show that MCPH1 interacts with and promotes the E3 ligase βTrCP2 to degrade Cdc25A independent of DNA damage.
Here , we show that MDMX binds to and promotes RB degradation in an MDM2-dependent manner.
Here we show that microglia constitute a barrier with profound impact on plaque composition and toxicity.
Here , we show that Mieap , a novel p53-inducible protein , induces intramitochondrial lysosome-like organella that plays a critical role in mitochondrial quality control.
Here we show that miR-27 , a somatic-enriched miRNA , is activated upon RNAi-mediated suppression of @date@ function in human embryonic stem cells.
Here , we show that mouse microRNA miR-196b can specifically target the @number@'UTR of the long insulin2 splice isoform.
Here we show that mTORC1 controls ketogenesis in mice in response to fasting.
Here , we show that muscle aging is characterized in Drosophila by the progressive accumulation of protein aggregates that associate with impaired muscle function.
Here we show that normal human dermal fibroblasts display a complex response to Platelet derived growth factor B ( PDGFB ) expression.
Here we show that Notch signaling interacts with the HIF-1α pathway in the process of ischemic neuronal death.
Here we show that over-expression of macroH2A1.1 , but not of macroH2A1.2 , is able to protect hepatocytes against lipid accumulation.
Here we show that over-expression of TRIP13 in human fibroblasts confers resistance to environmental stressors such as UV radiation and oxidative stress.
Here , we show that partitioning defective @number@ ( Par3 ) facilitates BACE1 retrograde trafficking from endosomes to the TGN.
Here we show that protein deacetylase SIRT7 is significantly downregulated in breast cancer lung metastases in human and mice , and predicts metastasis-free survival.
Here we show that protein oxidative and glycoxidative damage significantly increases during human brain aging , with a breakpoint at @number@ years old.
Here , we show that PrP ( C ) regulates the cleavage of neuregulin-1 proteins ( NRG1 ) .
Here , we show that reduced levels of the conserved RNA methyltransferase NSUN5 increase the lifespan and stress resistance in yeast , worms and flies.
Here , we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells.
Here , we show that S100A4 is a novel biomarker of GSCs.
Here , we show that SADS provides a unifying event in both progeria and normal senescence.
Here we show that scopoletin induces autophagy.
Here , we show that sTREM2 promotes microglial survival in a PI3K / Akt-dependent manner and stimulates the production of inflammatory cytokines depending on NF-κB.
Here we show that telomere length and telomerase activity are impaired in primary lymphocyte subsets from patients with CHH.
Here , we show that the abundance of phosphatidylethanolamine ( PE ) positively regulates autophagy.
Here we show that the bmk-1 gene is an important lifespan regulator in worms.
Here , we show that the CDK inhibitor p21 ( CDKN1A ) maintains the viability of DNA damage-induced senescent cells.
Here we show that the embeddedness in a professional environment imparts a temporal structure to sleep duration.
Here we show that the high-order processes of astrocytes in the mediobasal hypothalamus displayed shortening in fasting and elongation in fed status.
Here , we show that the histone demethylase KDM5C / JARID1C is required for proper DNA replication at early origins.
Here , we show that the lack of regeneration of these populations began ca.
Here , we show that the mitochondrial NAD-dependent deacetylase SIRT3 is a crucial regulator of the Warburg effect.
Here we show that the natural process of brain aging also accompanies a chronic and late-onset deterioration of neuronal autophagy-lysosomal system.
Here , we show that the novel hydroxyl-derivative of DHA ( 2-hydroxydocosahexaenoic acid - OHDHA ) has a strong therapeutic potential to treat AD.
Here , we show that the pro-proliferative transcription factor FOXM1 is elevated and activated in malignant melanoma.
Here , we show that these DNA transactions are promoted by RECQ5 DNA helicase in a manner dependent on its Ser727 phosphorylation by CDK1.
Here we show that the specialization for relative disparity is highly immature in 4- to 6-month-old infants but is adult-like in 4- to 7-year-old children.
Here , we show that the therian X started to accumulate new retroduplicate genes with overall sex-biased expression upon therian sex chromosome differentiation.
Here , we show that the transcription factor JUNB / AP-1 limits prostate cancer progression.
Here , we show that the transcription factor Tbx18 selectively marks pericytes and vascular smooth muscle cells in multiple organs of adult mouse.
Here we show that TNF-induced activation of MK2 results in global RIPK1 phosphorylation.
Here , we show that Top3β is also the most abundant mRNA-binding topoisomerase in cells.
Here , we show that TRF2 directly binds SIRT6 in a DNA independent manner and that this interaction is increased upon replication stress.
Here we show that UCP2 is a metabolite transporter that regulates substrate oxidation in mitochondria.
Here , we show that YAP knockdown sensitized MCF7 breast cancer cells to nutrient deprivation-induced apoptosis.
Here we show that young cycling HGPS fibroblasts exhibit chronic DNA damage , primarily in S phase , as well as delayed replication fork progression.
Here we show that κ opioid receptor ( KOR ) agonists act as anti-angiogenic factors in tumors.
Here we show the bioenergetics profile of human stem cells of embryonic origin differentiating along the hepatic lineage.
Here , we show the step-by-step methods currently used in our lab to handling the oligonucleotide microarray and miRNA microarray.
Here we show via a split-Cre technology that coincident activity of the hGFAP and prominin1 promoters is a hallmark of aNSCs in vivo.
Here , we sought to clarify such trends in Iran and compare them to trends reported for similar developing countries.
Here , we sought to identify SAD-associated genes and their potential mechanisms involved in SAD pathogenesis.
Here , we sought to investigate the concurrent and dynamic , lead-lag relationships among frontoparietal SC , FC , and reasoning ability in humans.
Here , we studied brain oscillatory activity in healthy young and old adults during visual information maintenance in a delayed match-to-sample task.
Here , we studied CD200R expression and its regulation in MDMs from @number@ PD cases , @number@ age-matched old controls , and @number@ young controls.
Here we studied CSB's DNA-binding and nucleosome-remodeling activities at the single molecule level in real time.
Here , we studied polyploidy-associated senescence induced by BMS-777607 in breast cancer cells and its prevention by mTOR inhibitor AZD8055 , leading to increased chemosensitivity.
Here , we studied the association of hippocampal volume with primacy recall in individuals with amnestic mild cognitive impairment ( aMCI ) .
Here , we studied whether a difference in temporal agonist and antagonist muscle activation exists between young and older persons during an RT-test.
Here , we studied whether DNA methylation in this sequence context may contribute to population- and age-specific effects of MCHR1 alleles in obesity.
Here we suggest that if the antioxidant treatment occurs before the physiological function-ROS dose-response curve reaches peak level , the antioxidants can attenuate function.
Here we summarize and discuss the current insights into placebo mechanisms and discuss the potentially widespread implications for research and clinical practice.
Here , we summarized the current knowledge about epigenetic regulatory mechanisms in ocular development and diseases.
Here we summarize how exercise impacts the major hallmarks of aging.
Here , we summarize how lipids function in myelin biogenesis , axon-glia communication and in supporting long-term maintenance of myelin.
Here , we summarize knowledge of SERMs ' impacts on metabolic , homeostasis , obesity and diabetes in rodent models and postmenopausal women.
Here , we summarize new findings characterizing the impact of aneuploidy on protein quality control.
Here , we summarize recent findings to address this question.
Here we summarize recent work and suggest a conceptual model in which hypothalamic microinflammation is a common mediator of metabolic syndrome and aging.
Here , we summarize the current advances in our knowledge of the mechanisms underlying specific immune-mediated elimination of senescent cells.
Here we summarize the current knowledge on glicentin biogenesis and physiological roles.
Here , we summarize the current understanding of lipid trafficking at the mitochondria and discuss emerging models for the mechanisms of lipid transfer.
Here , we summarize various aspects of immune system physiology and pathology in which epigenetic pathways have been implicated.
Here we summarize what is known about brain α-Klotho before focusing on the outstanding scientific questions related to its function.
Here , we synthesize increasing evidence on \ "antioxidative stress-induced \ " beneficial versus harmful roles on health , disease , and aging processes.
Here , we systematically explore these correlations.
Here , we systematically investigated age-related changes in homotopic RSFC in @number@ healthy individuals ranging in age from @number@ to @number@ years.
Here , we tested a network of @number@ genes in the postsynaptic density and associated complexes for an enriched association with intelligence.
Here , we tested both measures of the rate of senescence in a population of patients with end-stage renal disease.
Here , we tested the effects of skin stimulation on the postural control of elderly while standing barefoot.
Here , we tested the hypothesis that high-dose intravenous immunoglobulin ( IVIG ) could exert immunomodulatory effect in rat pups subjected to HI injury.
Here , we tested the hypothesis that these sources in amnesic MCI subjects further deteriorate over @number@ year.
Here we tested the hypothesis that these two variables could be related.
Here we tested the in vivo ability of synthetic lethal RNAi responses to treat glioblastoma.
Here , we tested this hypothesis in a well-defined AD group.
Here we tested this prediction.
Here , we tested whether age was associated with the activity elicited by durable memories.
Here , we tested whether BMP antagonists have an effect on the prevention of wrinkle formation.
Here we tested whether end-stage renal disease ( ESRD ) -related T-cell alterations are compatible with the concept of premature immunological aging.
Here we test for performance tradeoffs in human athletes.
Here we test if the same factors that lead to poor credit scores also lead to poor health.
Here we test segmental bioelectrical impedance spectroscopy ( S-BIS ) to assess muscle intracellular mass and composition.
Here , we test the hypothesis that free water is elevated in the substantia nigra for Parkinson's disease compared with control subjects.
Here we test two overlooked sources of variation in @number@ European ancestry women : low-frequency protein-coding variants and X-chromosome variants.
Here we took a phylogenomic approach to identify the genetic targets of natural selection for elongated life span in mammals.
Here , we undertook a developmental transcription factor expression study , focusing on markers associated with specific classes of Layer V projection neurons.
Here , we use a family-based study of longevity to study heritability of LTL in @number@ individuals.
Here , we use a label-free quantitative proteomic approach to characterize the lysine succinylome in liver mitochondria and its regulation by the desuccinylase SIRT5.
Here , we use a model of closed-loop sensorimotor control to examine the functional causes of motor control deficits during aging.
Here , we use a surface plasmon resonance method to confirm that both peptides show the desired binding specificities.
Here we used a dual-regression approach to investigate age-related alterations in resting-state networks.
Here we used a modified Triplets Learning Task to investigate if an age deficit occurs even when sequentially-presented predictive events remain in view simultaneously.
Here we used a tailor-made design to study indirect transmission experimentally , using two different zoonotic bacteria in broilers.
Here we use diffusion tensor imaging to test whether changes in white matter are involved in VPL for older adults.
Here we used structural MRI to measure cortical thickness.
Here we use fluorescence live imaging of peripheral nerve and central nervous system tissue explants to investigate vesicular and mitochondrial axonal transport.
Here , we use highly variable tasks , which overlap in targeted processing demands ( \ "overlapping variability \ " framework ) .
Here , we use nucleolus genomics and single-cell experiments to address these questions in human embryonic fibroblasts during replicative senescence.
Here , we use our model of chronological aging in primary human ASCs to examine genome-wide transcriptional networks.
Here , we use Xenopus laevis as a model organism to study spinal cord repair.
Here , we utilized EFAD carriers [ 5xFAD Trigonella foenum-graecum seed extract has demonstrated hormone modulatory activity , providing biological plausibility for relieving menopausal symptoms.
Here we utilize single cell transcriptional analysis to determine the effect of aging on MSC population dynamics.
Here , we will attempt to review new molecular approaches , which are currently being exploited in order to ameliorate the diagnosis of thyroid nodules.
Here , we will describe the recent findings about the role of these structures in the regulation of gene expression.
Here , we will discuss the role that the caspases play in neuronal function , dysfunction , and death.
Here we will focus on chemical approaches for generating induced pluripotent stem cells , neurons , cardiomyocytes , hepatocytes and pancreatic β cells.
Here , we will review data in support of PAPP-A as a therapeutic target to promote healthy longevity.
Here , we will review how the Journal of Neurochemistry can contribute to increasing the value of preclinical and translational research.
Here we will review our current knowledge on the role of adult hippocampal neurogenesis in memory and in the pathophysiology of memory.
Here , we will review the contribution of the NR4A orphan NRs to integration of cytokine signalling in inflammatory disorders.
Here , while we confirm that TAp73 expression enhances anabolism , we also substantiate its role in inhibiting proliferation and promoting cell death.
Here , young and older adults stood upright and executed or imagined manual reaching movements.
Hericium erinaceum is an edible and medicinal mushroom widely used in Korea , Japan , and China.
Hericium erinaceus ( Bull. )
Hericium erinaceus ( HE ) is a fungus inhabiting the mountainous areas of the northeast territories in Asia.
Heritabilities were comparable to AD , suggesting MCI as an appropriate phenotype for genetic association studies.
Heritability analyses were conducted in @number@ twins ( @number@ monozygous and @number@ dizygous pairs ) .
Heritability analyses were conducted using maximum likelihood structural equation twin modeling.
Heritability estimates for any MCI and amnestic MCI averaged .40-.48.
Heritability estimates for cross-sectional hip and spine BMD were high ( ranging between @percent@ and @percent@ ) at different ages.
Heritability estimates were little influenced by shared environment , most likely due to the homogeneity of lifestyle and environmental factors in our study population.
Heritability estimates were @percent@ for mean reaction and @percent@ for range in reaction.
Heritability explained @number@ % of IGF-1 variation adjusted for age and in unadjusted sample was independent of age.
Heritability for identifying odors was low , in contrast to that for cognition.
Heritability of age-dependent LTL attrition rate was estimated at @percent@ ( @percent@ CI @percent@ to @percent@ ) .
Heritability of longitudinal change was found in @number@ of the @number@ tests , ranging from @number@ to @percent@.
Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified.
Heritability of these phenotypes and their association with candidate single-nucleotide polymorphisms ( SNPs ) , and SNP data from genome- and exome-wide arrays were explored.
Heritability was moderate for FEV1 , handgrip , and FTSST ( 55-60% ) but insignificant for FVC.
Hermeneutic methods and phenomenological reflection were used to analyse the data.
Hermeneutic phenomenology underpinned the study's interpretive research approach.
Hernial disease being systemic , a similar ECM should be present throughout the body.
Herpes simplex virus @number@ has to overcome skin or mucosa barriers to infect its human host.
Herpes simplex virus @number@ ( HSV-1 ) has been implicated as a risk factor for AD and found to co-localize within amyloid plaques.
Herpes zoster ( HZ ) results from the reactivation of the varicella zoster virus latent in the sensory ganglia when cell-mediated immunity is altered.
Herpes zoster , recurrent infection of VZV occurs when the cell-mediated immunity to VZV declines.
HERRA yields over @percent@ increase in heritability estimate compared to GCTA or LDAK.
Her story illustrates the complex interplay between age , life phase , and sociocultural and historical contexts.
Her younger sister , @number@ years old , exhibited hypertension , hyperfiltration , and microalbuminuria.
Heshouwuyin significantly improved sperm function and serum testosterone levels , and improved testicular morphology.
H-E staining was used to observe infiltration of inflammatory cells in periodontal lesions.
Heterogeneity across studies was assessed with the Cochran Q test.
Heterogeneity between studies was assessed by the Cochran's chi-square test and quantified through an estimation of the I².
Heterogeneity between studies was investigated using sub-group analysis and meta-regression.
Heterogeneity in health status was evaluated ( n = 1260 ) by determining their Frailty Index ( FI ) .
Heterogeneity of the included studies precluded meta-analysis.
Heterogeneity , publication bias , subgroup and meta-regression analyses were performed.
Heterogeneity was explored through meta-regression and subgroup analysis.
Heterogeneity was high ( I ( @number@ ) = 89.65% ) .
Heterogeneity was moderate but significant.
Heteroplasmic G1576A ( MT-RNR1 ) and G2975A ( MT-RNR2 ) alterations are expected to make the stem structure of mitochondrial ribosomal RNAs unstable.
Heteroplasmy occurred in a total of @number@ different positions within HVS-I , and was the most frequent at fast-mutated positions @number@ @number@ and @number@
Heterosexual couples face prostatectomy-related sexual side-effects having experienced developmental sexual losses.
Heterosexual couples ( N = @number@ ) participated.
Heterosexuals , fewer of whom have non-kin-based networks , place a stronger value on access to a social network via CMPs.
Heterozygosis of rs113938200 ( p.Asn368Asp in MAp44 ) was associated with a reduced MAp44 concentration of @percent@ ( P = 0.005 ) .
Heterozygosity for the KI mutation decreased production of Aβ40 and Aβ42 , increased the Aβ42 / Aβ40 ratio , and exacerbated Aβ deposition.
Heterozygous and homozygous genotypes recruit fewer follicles at younger ages , thus preserving OR into advanced age.
Heterozygous deletion of Synj1 protected neurons from Aβ-induced synaptic loss and restored learning and memory in a mouse model of AD.
Heterozygous lymphoblastoid cell lines show the same pattern of allele-specific DNA methylation.
Heterozygous TREM2 mutations modulate the risk of FTD in addition to increasing susceptibility to AD.
Heterozygous triggering receptor expressed on myeloid cells ( TREM2 ) mutations are an Alzheimer's disease ( AD ) risk factor.
Hetil. , @number@ 157 ( @number@ ) , 2019-2027.
Het mice only showed a clear degradation in their fiber structure in fast-twitch muscles from the adult to the presenescent age bin.
He trepanned himself in @number@
HE was defined as an ICH volume increase > 33% or > 6 mL from baseline within @number@ hours.
He was diagnosed as having intermittent sinus bradycardia and sinus arrest , induced by topical β-blocker therapy.
He was diagnosed with clinical Alzheimer's disease ( AD ) , with additional features consistent with behavioral variant frontotemporal dementia.
He was diagnosed with Graves ' disease ( GD ) and central diabetes insipidus ( CDI ) .
He was finally found to have an aortic arch aneurysm.
HE was not significantly different between groups during the recovery periods.
He was treated with hydration , zoledronic acid , cinacalcet and high-dose unfractionated heparin.
He was treated with therapeutic anticoagulation resulting in improvement.
HF acid etching is a crucial step in resin / ceramic bonding.
HF can be seen in up to @number@ % of adults aged @number@ years or older.
HF-diagnoses were established by review of hospital records and adjudicated according to prespecified criteria.
HF is an acute stress that triggers a state of inflammation which may affect immune responses and physical recovery.
HF medication was intensified to a larger extent in the NT-proBNP-guided group.
HF overlaps in symptoms and signs and has a common comorbidity with COPD , so that diagnosis of COPD is difficult in patients with HF.
HF patients experience decreased libido and erectile dysfunction ( ED ) .
HFpEF prevalence was @percent@ ( 35 / 1274 ) , and increased with aging in the whole cohort.
HF , TP , and time domain parameters of HRV and SC increased significantly following yogic practice.
HF with preserved EF was more common in participants without vascular disease ( @percent@ vs. @percent@ , P = @number@ ) .
HgbA1C , fasting insulin and glucose levels , and HOMA calculations were ascertained.
HG decreases eNOS activation and induces total VCAM-1 expression in HAEC through a hyperosmolar mechanism.
HGMVC wasn't related to leg extension torque or power , or balance ( r = 0. @date@ ; p > 0.05 ) .
HGPS affects mesenchymal lineages , including the skeletal system , dermis , and vascular smooth muscle ( VSMC ) .
HGPS generates a more prominent adventitial fibrosis than typical CVD.
HGPS has distinct cutaneous manifestations during the first @number@ years of life that may be the first signs of disease.
HGPS-iPSCs show absence of progerin , and more importantly , lack the nuclear envelope and epigenetic alterations normally associated with premature ageing.
HGS among Singapore older adults were relatively low compared to Western and other Asian countries.
HGS did not predict subsequent cognitive decline.
HGS was obtained using a Jamar Plus + digital hand dynamometer.
HHCW routinely perform physical tasks with increased risk for occupational musculoskeletal injuries.
Hhcy has been attributed to deficiency of B vitamins which can adversely affect the brain and result in memory loss and poor attention power.
HHH has a panethnic distribution , with a major prevalence in Canada , Italy and Japan.
HHH syndrome enters in the differential diagnosis with other inherited or acquired conditions presenting with hyperammonemia.
HHT1 patients have a higher prevalence of brain arteriovenous malformation ( AVM ) than the general population and patients with other HHT subtypes.
HHV-6 showed a @percent@ positivity in PBL samples from AD and @percent@ from controls ( p = @number@ ) .
Hibernation is a state of reduced metabolic activity used by some animals to survive in harsh environmental conditions.
Hidden barriers to visit a medical facility especially for young busy workers have been neglected in the aging society.
Hidden Markov modeling was used to characterize states of ALM , strength , and performance and model transitions leading to sarcopenia and death.
Hierarchal linear regression was used for final analysis.
Hierarchical classifications had acceptable reliability and levels demonstrated hierarchical properties.
Hierarchical cluster analysis was applied to evaluate patterns of multimorbidity with gender stratification.
Hierarchical cluster analysis was conducted to identify network types.
Hierarchical linear modeling was used.
Hierarchical linear modeling was used to analyze the intrapersonal and interpersonal differences in BMI.
Hierarchical linear modeling was used to explore LTL dynamics using LTL data from S1 , S2 , and S3.
Hierarchical linear modelling was used to examine the effect of the interaction between intention to leave , job change and time on cynicism.
Hierarchical linear models were employed in depicting variations in self-rated health across White , Black , and Hispanic Americans.
Hierarchical linear regressions were conducted to determine the associations between social capital variables and HRQOL.
Hierarchical linear regressions were used for data analysis.
Hierarchical logistic regression analyses were conducted for bereaved dementia caregivers ( N = @number@ ) .
Hierarchical logistic regression models were used to assess the odds of breast cancer screening participation.
Hierarchical logistic regression models were used to model the dependent variables of OT and PT service use within @number@ d of the initial assessment.
Hierarchical logistic regression was conducted to identify risk factors of depressive symptoms.
Hierarchical models were then used to calculate risk-standardized complication rates to account for differences in case mix and procedural volume.
Hierarchical , multiple-regression analyses were conducted on the Canadian Community Health Survey ( Cycle @number@ 2009-2010 , N = @number@ ) .
Hierarchical multiple regression was conducted to examine whether ERA would predict physical activity by controlling other factors.
Hierarchical processing is frequently investigated using Navon figures ( large letters made up of smaller ones ) .
Hierarchical regression analyses assessed the relationship between psychosocial factors and alcohol use in a 50- to 59-year-old group , and a 60-years-and-older age group.
Hierarchical regression analyses were conducted to determine whether discounting preferences and response consistency accounted for variance in functional ability over and above relevant demographic characteristics.
Hierarchical regression analyses were used to examine predictors of cognitive performance for each cognitive measure.
Hierarchical regression analyses were used to explore the hypothesis that different facets of perceived social support influence performance on measures of executive functioning.
Hierarchical regression and structural equation models ( SEM ) were used to analyze the data.
Hierarchical regression revealed that apathy significantly predicted PI but depression did not significantly add to the prediction.
Hierarchical regressions showed that baseline participation in social activities moderated cognitive status differences in EF.
Hierarchical relationships between areas of distinctive pathologic deposits were then studied.
Hierarchical thermodynamics forms the design diversity of culture and art.
Hierarchical thermodynamics is the mirror of Darwin-Wallace's-theory.
HIF-1a promotes an hypoxic-like ( Warburg effect ) state in the cell.
HIF1A was knocked down in Hepa1-6 cells with small interfering RNAs.
HIF-1 controls oxygen delivery , by regulating angiogenesis and vascular remodeling , and oxygen utilization , by regulating glucose metabolism and redox homeostasis.
HIF1α knockdown results in decreased HOTAIR expression under hypoxia.
HIF-1α upregulation induced proteasomal degradation of homeodomain-interacting protein kinase-2 ( HIPK2 ) , the p53 apoptotic activator.
HIF is a transcription complex that responds to decrease oxygen in the cellular environment.
High activeness in health and security dimensions should also be promoted to keep the elderly healthy and protect from abusive behavior.
High adherence to a Mediterranean-style diet is associated with a slower decline of mobility over time in community-dwelling older persons.
High adherence to the green food pattern was positively related to high adult SES in both sexes.
High adherers to the full intervention had better emotion regulation and quality of life than low adherers.
High-affinity Na ( + ) -dependent dicarboxylate cotransporter ( NaDC3 ) can transport Krebs cycle intermediates into cells.
High-affinity sodium-dependent dicarboxylate cotransporter @number@ ( NaDC3 ) is a key metabolism-regulating membrane protein responsible for transport of Krebs cycle intermediates.
High age-11 IQ tended to buffer effects of adverse environments on physical and mental problems in old age.
High air velocity reduced the number of males surpassing the @number@.0°C Tre threshold from @percent@ ( Low ) to @percent@ ( High ) .
High and low emotional trade-off difficulty were manipulated between participants through different attribute labels of available cars.
HIGH and LOW + resulted in greater improvements in 1RM strength than LOW ( p < 0.05 ) .
High and low total and LDL cholesterol may confer both risk and benefit for suboptimal cognitive function at different ages.
High AR expression was associated with poor overall survival in tobacco-using ESCC patients but not in ESCC patients not using tobacco.
High-association lists resulted in higher recognition of both studied items and critical lures.
High attrition and poor compliance are two difficulties frequently encountered in such programs.
High baseline intermittent knee pain predicted poor KOOS-FSR at year @number@ ( B = @number@ p = @number@ ) .
High blood pressure contributes to cerebral small and large vessel disease resulting in brain damage and dementia.
High blood pressure ( HBP ) is an important risk factor for cardiovascular morbidity and mortality , particularly in the elderly.
High blood pressure is a major cardiovascular risk factor.
High body mass index was significantly associated with uncontrolled hypertension only in men.
High BP was defined as BP at least 140 / 90 mmHg and / or taking antihypertensive drugs or following a specific diet.
High BTLA expression on mature B cells was linked to higher IgG responses to the H1N1 virus.
High burden was most often ( @percent@ ) due to one highly anticholinergic medication rather than a cumulative effect.
High business and living costs coupled with low reimbursement for health services makes it difficult to be competitive when recruiting physicians to Hawaii.
High CHD4 and 8-OHdG levels plus low expression of TSGs strongly correlates with early disease recurrence and decreased overall survival.
High coherence ( > threshold ) was observed between the two signals suggesting a strong relationship.
High concurrent , content and predictive validity and inter-rater reliability were found for GAS.
High-contrast ( @percent@ ) visual acuity , @percent@ low-contrast letter acuity and @percent@ low-contrast letter acuity were assessed in @number@ MS patients.
High correlation ( r ( @number@ ) > 0.5 ) was found for @number@ diseases.
High cortisol ( Cor ) was associated with higher Err , while high DHEA / S was associated with shorter RT.
High cortisol has been associated with deleterious effects on cognition.
High CXCL10 correlates with the presence of clinical risk factors but not with clinical symptoms and quality of life.
High-density lipoprotein cholesterol and surprisingly small dense LDL-C levels were significantly ( P < @number@ ) higher in Fukuoka than in Framingham.
High-density lipoprotein ( HDL ) is a strong antioxidant , anti-inflammatory , and antisenescence molecule.
High-density lipoprotein was under the normal criteria ( @number@ mg / dL ) in women.
High dietary acid load is more likely to result in diabetes and systemic hypertension and may increase the cardiovascular risk.
High dietary acid load may be detrimental to bone mineral density ( BMD ) , although sufficient calcium intake might neutralize this effect.
High-dose Methotrexate ( MTX ) is the most useful cytotoxic drug used in the treatment of primary central nervous system lymphoma ( PCNSL ) .
High doses of SUAs increased ABCG1 expression in RAW264.7 cells , promoting HDL-mediated cholesterol efflux in an ABCG1-independent manner.
High education was associated with the most favourable cognitive trajectory , and after adjusting for cognitive decline , with an increased mortality risk.
Higher 8-OHdG in older subjects with T2DM suggests that both aging process and diabetes could contribute to the development of DNA damage.
Higher absolute muscle mass measures and not being malnourished at admission were significantly associated with the likelihood of survival.
Higher ACTH levels before treatment predicted a recurrence of CD.
Higher age was also associated with lower degree of biochemical thyrotoxicosis in nodular toxic goiter.
Higher ALM was associated with a lower risk of mortality.
Higher amounts of weight gain were associated with greater risks of major chronic diseases and lower likelihood of healthy aging.
Higher amounts of β-galactosidase are also detectable in UVB-RHE.
Higher antibody levels were not associated with a history of colitis.
Higher anxiety score predicted worse memory performance and decreased frontal perfusion.
Higher anxiety was associated with greater declines in processing speed over the duration of @number@ years and worsening attention over a span of @number@ years.
Higher apnea , microarousal , and body mass indexes were correlated to increased rCBF in the basal ganglia , insula , and limbic system.
Higher arterial stiffness is associated with increased risk of atherosclerotic events.
Higher ASA-status and ACE-score were significantly associated with postoperative medical and surgical complications and a higher severity of the complications.
Higher AWT Pi10 was associated with a lower FEV CONCLUSIONS : AWT decreases with higher age , possibly reflecting structural changes of the airways.
Higher baseline estradiol levels and rapid declines in estradiol over time were associated with rapid increases in LUTS and rapid decreases in maximum flow rate.
Higher BDNF methylation was independently associated with the prevalence and incidence of depression and severe depressive symptoms.
Higher BMI , WC , and WHR were associated with larger WMHV and WC with brain infarcts , before adjusting for vascular risk factors only.
Higher body satisfaction , less psychosocial discomfort , and a greater degree of sexual symptom discomfort predicted life satisfaction.
Higher BPH scores were associated with more CI ( p < 0.001 ) .
Higher brachial systolic pressure and brachial pulse pressure were both associated with poorer Stroop processing.
Higher brain creatine is associated with improved neuropsychological performance , and recently , creatine supplementation has been shown to increase brain creatine and phosphocreatine.
Higher breastfeeding frequency was observed among mothers who spent more time in the temascal.
Higher catecholamine levels were nearly-significant with shorter LTL ( p = 0.055 ) .
Higher cerebrospinal fluid pressure may lead to higher retinal vein pressure and subsequently higher retinal capillary blood pressure increasing fluid and blood extravasation.
Higher childhood household SES was associated with increased odds of high BMI latent class membership relative to the poorest households.
Higher childhood SES was associated with better semantic memory.
Higher cholesterol and BMI related to increased cortical thinning.
Higher CIRS scores were associated with a lower treatment adherence ( p < @number@ ) and greater cognitive impairment ( p < @number@ ) .
Higher cognitive functioning , symptoms of depression , and living alone increased the willingness to obtain nursing care.
Higher concentrations of arachidonic acid were associated with smaller muscle size ( P-trend : @number@ ) .
Higher concentrations of CRP appear to be associated with greater skeletal muscle AT infiltration , lower subcutaneous AT , hyperinsulinemia , and insulin resistance.
Higher concentrations of HDL-C subfractions in the large and medium particle size ranges were associated with poorer embryo quality.
Higher Confusion Assessment Method for the ICU-7 scores were also associated with increased length of ICU stay ( p = @number@ ) .
Higher Conscientiousness and lower Extraversion were associated with better cognitive status and less decline.
Higher Conscientiousness might also predict lower risk for severe cognitive decline , especially for individuals with mild cognitive deficits.
Higher consumption of lamb was also associated with increased risk of CRC ( RR = @number@ @percent@ CI = @number@ to @number@ ) .
Higher creatinine-adjusted urinary total arsenic concentrations were associated with a higher prevalence of proteinuria.
Higher DASH and Mediterranean diet scores were associated with higher average 3MS scores.
Higher depressed mood and somatic symptoms subscale scores were associated with greater increases in WML volume over time at older ages.
Higher DHA incorporation coefficients were observed in several brain regions , particularly in the entorhinal subregion , an area affected early in AD pathogenesis.
Higher diet quality and HALex scores , and overweight status , were associated with reduced all-cause mortality in a cohort of advanced age.
Higher EC was also linked to stronger early selection of target letter-forms , but did not modulate the seemingly less demanding task of color selection.
Higher education and lower age were associated with better performance.
Higher education , better family functioning and fewer diseases contributed directly to improved performance in physical and mental components , regardless of religiousness.
Higher education could be a risk factor for these conflicts.
Higher education has also been associated with risk of SSAs , while an inverse association between NSAID use and SSAs has been reported.
Higher education helps to overcome the negative consequences of a poor family background.
Higher education level and increased age were associated with better knowledge of PFD and ED.
Higher education level was shown to be the protective factor for these transitions ( @number@ and @number@ ) .
Higher education , Mini-Mental State Exam ( MMSE ) , better health , and younger age related to higher baseline performance.
Higher education predicted lower BMI levels and was not associated with the rate of change.
Higher education was associated with higher self-efficacy and better performance on all cognitive tests.
Higher education was associated with transition to a healthy diet ; lower education was associated with stability in an unhealthy pattern.
Higher education was significantly associated with a decreased risk of multimorbidity in the all-region analyses.
Higher empathy scores were related to the ASD subscale attitude of acceptability of aging and to greater exposure to older adults outside of clinical practice.
Higher evening cortisol level was associated with slower reaction time and lower verbal memory.
Higher expression of CAXII in breast cancer is indicative of lower grade disease.
Higher family income and greater satisfaction with access to MS-focused care were associated with lower risk of nursing home admission.
Higher financial satisfaction and social participation were protective factors from frailty for the developing frailty group and high risk of frailty group , respectively.
Higher flavonoid intake may attenuate these effects , possibly by decreasing TLR2 methylation.
Higher FoR was associated with higher depression and lower QoL.
Higher frequency of MVPA was associated with better scores in @number@ QOL domains.
Higher FT4 was associated with atrial fibrillation ( P < @number@ ) and heart failure ( P = @number@ ) .
Higher general intelligence attenuates age-associated cognitive decline and the risk of dementia.
Higher Hcy is directly related with serum creatinine and uric acid ( P < @number@ ) .
Higher Hcy levels have been associated with global DNA hypomethylation.
Higher heart rate at rest ( p < @number@ ) was the only variable significantly associated with the risk of syncope.
Higher HOMA-IR predicted hypermetabolism in MCI-progressors and hypometabolism in AD in medial temporal regions.
Higher IgG levels were associated with exposure to ETS ( P < @number@ ) , while lower levels were associated to having atopy.
Higher immunoglobulin G antibody levels among those seropositive to CMV were also associated with shorter LTL at follow-up.
Higher impulsivity , however , predicted exaggerated responses to angry faces in fronto-opercular and dorsomedial prefrontal cortex ( pcorr < 0.05 ) .
Higher income was associated with better cognition at baseline and reduced rates of decline in working memory.
Higher insulin-like growth factor binding protein-3 ( BP3 ) was associated with longer DSpan.
Higher intakes of α-tocopherol ( p = 0.050 ) and vitamin C ( p = 0.017 ) were associated with increased dermal intensity.
Higher job demand was associated with increased injury risk.
Higher lability of mental processes , sympathetic activity , and personal anxiety are associated with choleric temperament.
Higher level and severity of injury were associated with higher levels of social disconnectedness.
Higher-level functional capacity was assessed using a validated questionnaire scale.
Higher level of frailty among elderly patients can be considered as a determinant of lower adherence.
Higher levels of both IGFBP-3 and IGF-I were associated with higher eBMD.
Higher levels of catecholamines and low frequency ( LF ) power of HRV was noted with advancement of age.
Higher levels of CD were detected in neck skin than in buttock skin in both German and Japanese women.
Higher levels of cognitive complaints were associated with increased activity in insular , lingual and cerebellar areas during memory tasks.
Higher levels of docosahexaenoic acid , vitamin D , and physical activity related to cortical sparing.
Higher levels of education and income have a positive association with survival expectations , and these associations persist even when conditioning on self-reported health.
Higher levels of education and wealth significantly reduced the odds of an undiagnosed condition and untreated morbidity.
Higher levels of erythrocyte creatine were associated with higher IVPG ( r = 0.437 , p < 0.001 ) .
Higher levels of estradiol are associated with smaller carotid diameters in both the sexes.
Higher levels of functional abilities were predicted by prior measures of and improvements in maternal depressive symptoms.
Higher levels of GPS predicted amplified NA responses to daily stress , and controlling for GPS eliminated age differences in NA responses to stressors.
Higher levels of moderate PA were associated with lower odds of NCI ( p = @number@ ) , even when covariates were modeled.
Higher levels of oxHDLlipids are additionally associated with higher oxLDLlipid levels.
Higher levels of physical activity and physical fitness were correlated with higher self-reported HRQOL.
Higher levels of psychological distress among spouses are explained mostly but not completely by higher levels of care provision.
Higher levels of social engagement are associated with better physical and cognitive functioning in American Indian and Alaska Native elders.
Higher levels of social integration were significantly associated with lower odds for depression.
Higher levels of Sokolow-Lyon index indicate higher degrees of LVH.
Higher levels of task difficulty were associated with slower speed in both groups.
Higher levels of well-being are associated with longer life expectancies and better physical health.
Higher link strengths are found in men consistently in cardio-cerebral links in N2 , but not significant.
Higher LV mass / volume ratios in older women might be a contributor to the preferential development of diastolic heart failure in this population.
Higher magnitudes of the BOLD signal in older adults may represent a compensatory pattern to counter age related deterioration in motor control systems.
Higher male incidence and greatest incidence occurring at approximately the age of @number@ is similar to data from other developed countries.
Higher masked thresholds were obtained for forward maskers with greater inherent envelope fluctuations for younger adults with normal hearing.
Higher minimum SpO₂ during REM sleep was associated with less gliosis and neuronal loss in the locus ceruleus.
Higher MMSE was related to larger training effects , larger linear slopes , and smaller booster effects.
Higher mobility and physical ability are desired for maintaining EFs capability.
Higher MPI values were significantly associated with higher 1-year mortality in older patients with CKD.
Higher neighborhood income was associated with slower deterioration in HbA1c value among White teens , but not among Hispanic or Black teens.
Higher NLR was associated with aging and established CV risk factors , previous percutaneous coronary revascularization , acute presentation , and more complex pharmacological therapy.
Higher order control processes are discussed as an explanation of the relation between executive functions and motor skills.
Higher-order moments of the wavelet coefficient distribution may provide a more diagnostic index of wavelet distribution abnormality than its variance.
Higher order skills can be very powerful in helping geriatric cancer patients find meaning and dignity at the end of life.
Higher pain-related fear and pain unpleasantness occurred with the electric-cooled apparatus.
Higher perceived mastery scores were not consistently associated with decreased risk.
Higher performance occurs among older swimmers only in @number@ m butterfly ( female @number@ 1st≠2nd quarter , p = 0.003 ) .
Higher PFOA was associated with better performance in tasks of the California Verbal Learning Test and the Wisconsin Card Sorting Test.
Higher PFOS was associated with improved performance in a Wechsler Memory Scale subtest and Block Design Subtest ( BDT ) total scores.
Higher phase across all frequency ranges was associated with greater FA and lower MD ( P < 0.005 ) .
Higher physical activity levels were protective in both genders , and higher household income was protective in women.
Higher PIB uptake in ApoE4- patients was particularly significant in right lateral frontotemporal regions.
Higher PI was associated with greater WMH ( P < 0.005 ) .
Higher plasma 25OHD concentration was associated with greater insulin sensitivity and lower insulin secretion.
Higher plasma DHA in older adults could be a sign that their fish or DHA intake is higher.
Higher postural oscillations were observed in the anteroposterior direction while mediolateral sway was reduced in the third trimester of pregnancy.
Higher PPARβ / δ expression is also correlated with increased senescence observed in human benign neurofibromas and colon adenoma lesions in vivo.
Higher predation significantly decreased the total population size , enlarged the shared resource pool , and redistributed energy reserves for mature individuals.
Higher presentation levels may not always lead to better performance when the task involves recall of words previously heard.
Higher pretreatment AMH was associated with lower bone mineral density at both lumbar spine and hip at @number@ yr ( P < @number@ ) .
Higher prevalence of certain skin diseases was related to the severity of disability or major systemic diseases of the residents.
Higher prevalence of neuropathy has been described in patients with Parkinson's disease ( PD ) in comparison with age and gender-matched controls.
Higher prevalence of tobacco and alcohol use , co-infection with viral hepatitis and traditional cardiovascular risk factors such as hypertension and hyperlipidemia contribute as well.
Higher PTLE levels attenuated the association between age and PTS symptoms.
Higher pulse pressure in older people is associated with smaller aortic lumen area and greater aortic wall stiffness and thickness and left ventricular volume.
Higher Q10 levels in plasma are related to lower lipoperoxidation and oxidized LDL levels in elderly people.
Higher QOL was not significantly associated with neighborhood walkability.
Higher quality of life scores were associated with higher MMSE ( p = @number@ ) and self-efficacy scores ( p = @number@ ) at admission.
Higher rates of bleeding have been also reported with the twice daily versus once daily dosing of darexaban in a phase II study in ACS.
Higher RDW values were strongly associated with an increased risk of death.
Higher risk drinkers were most common in the extreme VACS index group , and were absent in the low index group.
Higher risk was seen among rectal cancer patients and among patients aged ≤50 years old at the time of cancer diagnosis.
Higher scores indicated closer adherence to dietary guidelines.
Higher self-efficacy was associated with better set-switching and attention / inhibition.
Higher serum albumin levels and angiotensin-converting enzyme inhibitor / angiotensin receptor blocker use were associated with lower eGFRSCR.
Higher SES was associated with greater total brain volume-a putative global indicator of brain health and predictor of mortality-in whites.
Higher S-FSH concentration in menopausal transition was associated with increased SWS ( B @number@ 95%CI @number@ to @number@ ) after controlling for confounding factors.
Higher SL and SW variability may reflect more errors in foot placement and / or decreased center of mass control in the older groups.
Higher social capital indicators were positively associated with the mental and physical dimensions of HRQOL.
Higher socioeconomic status was protective.
Higher spatial resolution of strain imaging resulted in the detection of significantly higher local peak strains ( p ≤ @number@ ) .
Higher spiral scores were associated with poorer motor hand function as assessed using the Purdue Pegboard test.
Higher SSB intake was also associated with a greater increase in HOMA-IR ( P-trend = @number@ ) .
Higher steps , AEE and duration , but not intensity , were significantly associated with higher FA.
Higher strain from friends was significantly associated with higher executive function ( β = @number@ SE = @number@ p < @number@ ) .
Higher stretch-related work was associated with greater early diastolic filling in men only.
Higher syncope burden was also associated with lower performance ; however , this was largely explained by confounders.
Higher territorial roots were associated with a lower perception of social community resource availability ( r = @number@ p < @number@ ) .
Higher TSH was negatively associated ( P = @number@ ) and higher FT4 was positively associated ( P = @number@ ) with mortality.
Higher urate levels were significantly associated with lower allopurinol dose , male sex , increased BMI , increased alcohol intake and diuretic use.
Higher urinary epinephrine levels may reflect the importance of epinephrine in maintaining EE during fasting.
Higher urine PIIINP level was also associated with incident ESRD , but results were not significant in fully adjusted models.
Higher values of BMI and glucose were found in subjects with symptomatic enthesopathy.
Higher values on the FI indicate worse health status.
Higher whole-brain GM MD was associated with poorer RBANS performance in the 60-69 age group.
High erythropoietin levels have been shown to predict the risk of death among patients with chronic heart failure.
Highest AUDIT-C and AUDIT-C trajectory were correlated r = @number@
Highest genetic risk was found at @number@ to @number@ y , onset slightly below average age at onset ( AAO ) .
Highest quintile of CML-AGE was not associated with an increased risk of colorectal cancer ( multivariate RR = @number@ @percent@ CI , @number@.64-2.26 ) .
Highest-ranked discriminative SCPs reflect increases in long-range connectivity in adults between the frontal areas and posterior cingulate regions.
Highest versus lowest neighborhood quartile was associated with lower HbA1c ( @percent@ , p = 0.02 ) in unadjusted models.
High expression of ALDHs is a marker for stem cells of many organs including the lungs.
High expression of NaDC3 caused a prominent increase in intracellular levels of Krebs cycle intermediates and NADH.
High expression of p53 was localized in the cytoplasm , not in the nucleus.
High-fat feeding rescued the metabolic , transcriptomic , and behavioral phenotypes of Csb ( m / m ) mice.
High-fat / high-sucrose diets have shown both beneficial and detrimental influences on bone metabolism.
High ferritin levels in men with no major chronic diseases were also independently associated with an increased risk of cardiovascular mortality.
High fidelity of genome duplication is ensured by cooperation of polymerase proofreading and mismatch repair ( MMR ) activities.
High financial strain may be associated with increased oxidative stress , suggesting that oxidative stress could mediate associations between financial strain and poor health.
High-fit OA performed as well as YA on executive function measures.
High-flow mediated BA dilation was unchanged ( @number@.3±9.4% to @number@.5±7.2% , p = 0.2 ) .
High folic acid concentrations ( @number@ and @number@ μmol / L ) increased SAM : SAH ratios and cell viability.
High for age carotid-femoral PWV was identified in the reference normogram.
High for age PWV was found in @percent@ of patients.
High-frequency hearing loss is consistent with an accelerated aging ( presbycusis ) ; low-frequency hearing loss in middle age is unexpected.
High-frequency severe atherosclerosis / calcinosis is observed in aging , diabetes mellitus and chronic dialysis , which leads to cardiovascular events.
High-frequency ultrasound ( 20-100 MHz ) is a non-invasive technique that has been used to evaluate age-related dermal changes.
High-functioning status defined as the absence of dementia or disability with normal gait diagnosed by study clinicians.
High glucose alone did not result in greater production of ROS or telomere shortening.
High glucose induced premature senescence and EMT in PTCs in vitro , which was accompanied by down-regulation of AMPK / mTOR signaling.
High glucose ( @number@ and @number@ mM ) did not alter Klotho expression in TECs.
High glucose was used to induce premature senescence and EMT in human primary proximal tubular cells ( PTCs ) in vitro.
High high-density lipoprotein is associated with positive remodeling and high low-density lipoprotein with negative remodeling.
High homocysteine was associated with greater decline with a Cohen's d effect size of approximately @number@ compared to low homocysteine.
High IGFBP-1 and low IGF-1 / IGFBP-1 ratio are associated with all-cause mortality in older population.
High-impact weight-bearing exercise during youth may provide lifelong benefits in terms of bone mineral content , structure and strength , and consequently reduce fracture risk.
High income countries face the highest incidence and death rates ; however , obesity-attributed kidney cancer deaths are increasing in developing countries.
High-income countries have witnessed marked reductions in cardiovascular disease ( CVD ) in recent years.
High-income countries spend a greater proportion on direct costs : a pattern reversed for middle and low-income countries.
High-income groups will be the most affected because they are most likely to have financial assets and to be invested in the stock market.
High individual variability in the content of human rDNA suggests that this genomic region remained relatively unstable throughout evolution.
High-intensity exercise and longer duration of sleep were associated with higher concentrations of T and BioT.
High-intensity exercise produces transient hyperammoniemia , presumably due to AMP catabolism.
High-intensity interval exercise training ( HIT ) is emerging as an effective alternative to current health-related exercise guidelines.
High-intensity interval training ( HIIT ) may improve muscle power , but remains largely unstudied in ageing participants.
High-intensity resistance exercise ( REX ) training increases physical capacity , in part , by improving muscle cell size and function.
High inter-rater reliability was noted for EFAT2 ( ICC3 , @number@ = @number@ ) and the agreement between scores was confirmed by Bland-Altman analysis.
High iron intake may influence important brain health outcomes in later life.
High levels of adiponectin may mark or mediate age-related processes that lead to HF in older adults.
High levels of ALP are often encountered during routine blood investigation in elderly patients.
High levels of ANS fluorescence are associated with the endoplasmic reticulum ( ER ) , Golgi , and lysosomes-regions of protein folding and degradation.
High levels of cardiovascular fitness ( CRF ) and physical activity ( PA ) are associated with decreased mortality and risk to develop metabolic diseases.
High levels of PDGF , VEGF , IL-6R were detected in blood serum from young subjects when compared to middle-aged and aged donors.
High levels of physical activity seem to positively influence health and cognition across the lifespan.
High levels of plasma amyloid beta-42 ( Aβ42 ) were found in prestages of AD and also in depressed patients in cross-sectional studies.
High levels of PPIA were found in the CSF of SOD1 Advancing age is an independent risk factor for cardiovascular disease.
High levels of therapeutic self-care ability can be a protective factor against the occurrence of adverse events among home care clients.
Highlighted are the major efforts of a number of research teams , funding situations and outstanding examples of recent major research achievements.
Highlighted genes implicate cellular energy homeostasis , post-transcriptional gene silencing and fatty-acid amide signalling.
Highlighting is based on a simple formula inspired by the law of mass action.
Highlights from the 15th International Congress of Twin Studies are presented.
Highlights Walking football is a lower impact but authentic form of football that enables older players to extend their active participation.
Highly active antiretroviral therapy ( HAART ) changed the natural history of pediatric HIV infection.
Highly active antiretroviral therapy ( HAART ) has considerably improved the prognosis of HIV-infected patients.
Highly conserved insulin / IGF-1 , TOR , and sirtuin signaling pathways in turn control these critical cellular responses.
Highly consistent themes emerged for the two types of programs.
Highly crosslinked UHMWPE has become the bearing surface of choice in total hip arthroplasty.
Highly damaged platelets in pediatric flows are primarily found far downstream of the valve , as there is less flow recirculation in pediatric flows.
Highly educated Europeans can expect to live longer and spend more years in better health than those with lower education.
Highly educated subjects revealed focal hypermetabolism in the right hemisphere and lower recruitment of glucose metabolism in memory tasks.
Highly effective in removing menopausal symptoms is hormone replacement therapy.
Highly efficient dual-task processing is demonstrated when reaction time to each of two tasks does not differ between the dual-task situation and the single-task situation.
Highly frequent shopping may favour men more than women.
Highly rated needs were family information , assistance with caregiver burden , and behavioral symptoms.
' Highly satisfied older people ' reported proactive strategies , contrasted with lack of planning by ' dissatisfied older people'.
Highly selective α1A-receptor antagonists such as silodosin were developed specifically for the treatment of LUTS because non-selective antagonists were associated with cardiovascular adverse effects.
Highly significant correlations were observed in spring-winter , while association was absent during summer-autumn.
High MeDi adherence results in lower meat and dairy intake , which possess high AGE content.
High- , medium- and low-GI foods were not associated with risk of adiposity-related cancers or prostate and colorectal cancers.
High miR-31 expression , MLH1 methylation and MSI-high status were more frequently detected in SSAs from elderly patients than in those from non-elderly patients.
High molar ratios of peptide-to-crystallin were favourable for aggregation and precipitation.
High-molecular-weight DNA was isolated from blood mononuclear cells.
High-molecular-weight DNA was isolated from full fresh blood ( Newcastle ) and peripheral blood mononuclear cells samples ( Leiden ) .
High mortality , low reproductive performance , and widespread malnourishment are the systems ' main constraints.
High mutation frequencies and nuclear DNA fragmentation were observed in nth1Δ rad16Δ stationary-phase cells concurrent with apoptotic-like cell death.
High perceived exertion was associated with tiredness , weakness , and reported and observed mobility deficits.
High performance liquid chromatography , UV-visible spectroscopy and circular dichroism analytical methods provide reliable techniques for evaluating AGE formation of HSA adducts.
High-performing older adults differed in increased allocation of attention and inhibitory control ( indicated by a stronger P2-N2 complex ) from their low-performing counterparts.
High-performing older adults showed a similar interference effect as younger adults , whereas low-performing adults showed poor tracking performance overall.
High plasma AA / DHA ratios were observed in E4FAD compared to EFAD mice with other isoforms.
High plasma levels of apolipoprotein A-I ( apoA-I ) correlate with cardiovascular health , whereas dysfunctional apoA-I is a cause of atherosclerosis.
High plasma vitamin E levels were repeatedly associated with better cognitive performance.
High prevalence of co-occurring neuropathologies among older adults with dementia has implications for accurate diagnosis of dementia etiologies and development of disease-modifying strategies.
High prevalence of inadequacies for vitamins A , D , E , B2 , B3 ( especially among females ) , and B9 was observed.
High prevalence of long-term hospitalization.
High prevalence of small heart was noted in the study population , especially in women ( > 60% ) .
High prevalence rates of EVA and noteworthy large artery damage in young ages were found.
High PTH also predicted cognitive decline within a five-year follow-up ( OR @number@ ) , but the association disappeared at ten years.
High PTH levels have been reported in patients with chronic heart failure ( CHF ) .
High-quality clinical trials are needed to investigate if ARHL can be delayed or prevented in humans.
High-quality images of the conjunctiva , cornea , limbus , meibomian glands , and lymphoid structures during therapy can be obtained.
High-quality randomized , controlled trials examining empiric antibiotic therapy are needed.
High-quality spectra were obtained , which allowed a reliable quantification of @number@ metabolites including glutamate and glutamine.
High rank-order stability was observed in both cohorts.
High rates of psychiatric disorders may interfere with smoking cessation.
High reliability for all 1RM assessments was observed.
High-resolution echocardiography and magnetic resonance imaging have emerged as useful tools for testing the efficacy of pharmacological and genetic interventions in vivo.
High-resolution images at @number@ Tesla depict details of the internal structure of the hippocampus allowing for in vivo volumetry of different subfields.
High resolution MRI T1-weighted images were acquired in controls ( n = @number@ ) , and ALS patients ( n = @number@ ) .
High-resolution phase-contrast magnetic resonance imaging can now assess flow in proximal and distal cerebral arteries.
High-resolution separation of multiply phosphorylated peptides was primarily achieved using elution ranges greater than pH @number@
High-resolution structural MRI was performed ; cortical thickness and surface area were analyzed separately.
High resolution T1-weighted volume scans were acquired from @number@ healthy adults aged 25-64years.
High resolution ultrasound was used to measure common carotid CIMT.
High resveratrol popularity is a consequence of wide biological properties.
High risk APOL1 status was defined by @number@ copies of high-risk variants ; low risk if @number@ or @number@ copy.
High-risk APOL1 was not significantly associated with reduced eGFR ( aOR @number@ @percent@ CI @number@.9-2.5 ) .
High-risk human papillomaviruses ( HPV ) are the main etiologic factor for the development of cervical cancer.
High-risk patients should have appropriate non-pharmacological and pharmacological treatment to decrease the risk of subsequent fracture.
High rTL variability was observed between different organs from one individual.
High SAAG may be an independent predictor of mortality and is associated with higher cardiovascular and infection related mortality in the elderly.
High satisfaction was noted among the patients treated with this technique.
High satisfaction with the device operation , ease of treatments , safety , and wrinkle reduction was reported.
High scores at baseline posed a more than fourfold risk of being diagnosed with dementia.
High scores on thought suppression were correlated with task switching deficits.
High sensitive cardiac troponin T ( hs-cTnT ) was detected before and after the procedure.
High-sensitivity assays based on specific biomarkers ( e.g. cardiac troponins ) enabling earlier AMI diagnosis have recently become available in clinical practice.
High-sensitivity C-reactive protein correlated with all metabolic syndrome components in all age groups ( p < 0.001 for all ) .
High-sensitivity C-reactive protein ( CRP ) was assessed at both time points.
High-sensitivity C-reactive protein ( hs-CRP ) levels were measured using a chemiluminescent immunometric assay.
High-sensitivity C-reactive protein was also negatively correlated with Treg / Teff ratio ( r = -0.22 , P < 0.05 ) .
High sensitivity C-reactive protein was used as a marker of inflammation.
High-sensitivity-modified Glasgow prognostic score ≥1 was seen in @number@ patients ( @percent@ ) .
High sensitivity was found.
High-serum low-density lipoprotein levels were also observed in AhR ( - / - ) mice.
High SHBG is associated with bone loss and vertebral fractures.
High smoking rates , occupational risk factors , air pollution , and a differential health system may be related to this finding.
High-speed yoga may be an effective alternative program for those targeting cardiometabolic markers.
High-strain jobs and low job control were not associated with IMT independent of SEP.
HIGH tended to improve PT ( dyn240°s ) ( @number@ ) more than LOW or LOW + ( p = 0.064 ) .
High-throughput deep sequencing revealed @number@ known and @number@ candidate novel miRNAs that were differentially expressed among groups.
High-throughput genomic and proteomic technologies have generated a wealth of publicly available data on ageing.
High-throughput protein glycomics : Combined use of chemoselective glycoblotting and MALDI-TOF / TOF mass spectrometry.
High-throughput sequencing in the four remaining families identified germline mutations in noncoding sequences surrounding ACTRT1.
High-throughput techniques allow high-resolution , genome-wide investigation of genetic variants , epigenetic modifications , and associated gene expression profiles.
High total cholesterol and low vitamin B12 and folate levels increased the adverse effect of Hcy on egocentric and mixed navigation.
High total cholesterol prevalence in women was twice that observed for men ( @number@ vs. @percent@ ) .
High urinary output secondary to polydipsia was associated with proximal tubule dysfunction.
High vancomycin MICs were seen only if using Etest but not confirmed using standard reference BMD.
High volume physical activity reduced the total number of circulating leukocytes , neutrophils , and lymphocytes.
High VS negatively influenced the rate of global cognitive decline over time.
High VS was the only neuroticism trait significantly associated with cognitive functioning.
High white matter hyperintensity ( WMH ) burden was associated with increased central PWV , systolic BP , and MAP.
High workloads associated with curricula , lack of recognition of a scholar's achievements , and securing research funding were seen as barriers to scholarship.
HIIT increased VO ( 2peak ) more than CON ( between-group difference , p < @number@ ) .
HIIT reversed many age-related differences in the proteome , particularly of mitochondrial proteins in concert with increased mitochondrial protein synthesis.
Hikosaka et al.
HILAQ was successfully applied to the HT22 oxytosis model.
Hip and vertebral fractures are particularly relevant , being associated with significant mortality and disability.
Hip and vertebral fractures have important functional consequences and reductions in quality of life.
Hip , back , and heart surgery in the last year were associated with frailty.
Hip BMD was measured by dual X-ray absorptiometry ( DXA ) at all three time-points.
Hip cases presented with pain and immobility.
Hip , clinical vertebral ( spine ) , forearm and other fractures were estimated to increase by @number@ @number@ @number@ and @number@ respectively.
Hip extensors peak torque was the only significant neuromuscular parameter included in the linear regression analysis ( p < @number@ ) .
Hip fracture is a common occurrence in the elderly.
Hip fracture is one of the most common orthopedic conditions and is associated with significant morbidity and mortality.
Hip fracture patients ( > 60 years ) were included in our study and were followed up for @number@ year.
Hip fracture remains a major health problem for the elderly.
Hip fracture risk increases dramatically with age , and @percent@ of fractures are due to falls.
Hip fractures are becoming a prototype condition in the study of frailty.
Hip fractures are the most common ones and are usually correlated to a greater morbidity and mortality.
Hip fractures are the most serious fragile fractures , considering that controlling their risk factors will successfully prevent these fractures.
Hip fractures in the elderly are associated with impaired mobility , and increased morbidity and mortality.
Hip fracture sites involve trabecular bone , whose strength is determined by volume fraction and orientation , known as fabric.
Hip fractures were ascertained through telephone interviews / questionnaires or through record linkage with registries.
Hip fractures were not significantly associated with UA.
Hip instability and femoro-acetabular impingement cause damage to the rim of the acetabulum.
Hip OA like OA in other joints is heterogeneous and may manifest in early or late adult life.
Hip OA was defined as minimum JSW of < or = 2mm or < or = 2.5mm.
Hip pain is common in all age groups , and osteoarthritis of this joint is an increasingly recognized problem particularly in aging populations.
Hippocampal and ventricular volumes were also compared.
Hippocampal and ventricular volumes were manually delineated , whereas total gray matter ( GM ) volume was measured by automatic segmentation.
Hippocampal and white matter volume as well as the corpus callosum area were not significantly different across groups.
Hippocampal atrophy and ventricular expansion were both associated with greater decline in verbal memory and executive function.
Hippocampal atrophy and ε4 status did not add further predictive value.
Hippocampal atrophy correlated with increased auditory memory and gender , especially in males ( p = 0.0087 ) .
Hippocampal atrophy is associated with memory impairment and dementia and serves as a key biomarker in the preclinical stages of Alzheimer's disease.
Hippocampal atrophy was found in Tg mice compared with WT.
Hippocampal circuits are among the best described networks in the mammalian brain , particularly with regard to the alterations that arise during normal aging.
Hippocampal data included MRI-derived volume data normalized to midsagittal area and MRS-derived N-acetylaspartate to creatine ratios ( NAA / Cr ) .
Hippocampal data included volume data normalized to midsagittal area and N-acetylaspartate to creatine ratios ( NAA / Cr ) .
Hippocampal , entorhinal and perihinal cortices volumes were automatically segmented and then manually corrected to ensure validity of the volumetric assessment.
Hippocampal ( HC ) and amygdala ( AG ) variability throughout asymptomatic adulthood have not been often characterized.
Hippocampal long-term potentiation was also suppressed in an age-dependent manner , where significant deficits were observed after @number@ months of age.
Hippocampal magnetic resonance spectroscopy revealed lower glutamate levels in both Tg mice and a selective myo-inositol increase in TASTPM.
Hippocampal RNA-sequencing showed that @number@ genes are differentially expressed in the senile rats , most of them being downregulated.
Hippocampal sclerosis may also be comorbid with frontotemporal lobar degeneration , Alzheimer disease , and Lewy body disease.
Hippocampal sclerosis of ageing is a prevalent brain disease that afflicts older persons and has been linked with cerebrovascular pathology.
Hippocampal sclerosis of aging ( HS-Aging ) is a causative factor in a large proportion of elderly dementia cases.
Hippocampal sclerosis of aging ( HS-Aging ) is a common high-morbidity neurodegenerative condition in elderly persons.
Hippocampal sclerosis of aging ( HS-Aging ) is a common neurodegenerative condition associated with dementia.
Hippocampal sclerosis of aging ( HS-Aging ) neuropathology was observed in more than @percent@ of aged individuals in prior studies.
Hippocampal sclerosis was associated with T ( @number@ ) prolongation in the hippocampus and white matter of the temporal lobe.
Hippocampal shape and regional cortical thickness were compared with @number@ subjects with normal cognition ( NC ) .
Hippocampal shape differed between the two case groups for the left ( p < 0.04 ) but not right ( p < 0.21 ) hippocampus.
Hippocampal structural integrity is commonly quantified using volumetric measurements derived from brain magnetic resonance imaging ( MRI ) .
Hippocampal subfields and subregions were manually segmented using reliable volumetric protocols.
Hippocampal volume change was expressed in μL , and as a percentage of baseline volume.
Hippocampal volume declined in the control group , but higher preintervention fitness partially attenuated the decline , suggesting that fitness protects against volume loss.
Hippocampal volume has been linked to clinical outcomes , such as depression , dementia , and Alzheimer's Disease.
Hippocampal volume has been suggested as the primary neuronal correlate of delayed primacy recall in cognitively normal elderly individuals.
Hippocampal volume reduction was variably related to Aβ deposition.
Hippocampal volumes were assessed by high-resolution @number@ Tesla MRI.
Hippocampal volumes were automatically determined from structural MRI scans.
Hippocampal volumes were derived using image segmentation as implemented by FMRIB Software Library.
Hippocampal volumes were processed using FreeSurfer.
Hippocampal volume was determined using previously established segmentation protocols.
Hippocampal volume was not significant as a predictor of decline but was significantly associated with fornix volume and diffusivity ( P = @number@ ) .
Hippocampal volume was obtained from the Freesurfer and manually edited.
Hippocampal Zn²⁺ signaling may participate in synaptic plasticity such as long-term potentiation and cognitive function.
Hippocampus and entorhinal cortex volume were manually outlined on three-dimensional T1-weighted magnetic resonance images.
Hippocampus and ventricle sizes were measured.
Hippo pathway deregulation occurs in many human cancers , but the underlying mechanisms are not fully understood.
Hip protectors provide some benefit in reducing hip fractures in elderly patients in residential facilities.
HIP rats have brain microhemorrhages , white matter injury , and neurologic deficits.
His aging males ' symptoms ( AMS ) and international index of erectile function ( IIEF-5 ) scores were @number@ and @number@ respectively.
His family history of dementia was probably negative , since no family member with dementia was found or mentioned.
His hormonal examination revealed extremely low free testosterone values.
His injury severity score was high ( @number@ ) , but no severe brain injury was sustained.
His kidney function had already severely deteriorated.
His lumbar spine radiography revealed enlargement and sclerosis of the spinous processes which was confirmed by computed tomography , suggesting Baastrup's disease.
His main scientific interests include migration and invasion of glioma cells , biomarkers and radiosensitization.
His medical records showed his serum creatinine level to be @number@ mg / dL two years ago , which was abnormally high considering his age.
Hispanic respondents appeared more often to live with uncertainty about the cause of their symptoms and an accompanying concern about a future health consequence.
Hispanics are the largest minority group in the United States , approximately @percent@ of the population older than @number@
Hispanics have the greatest intraindividual variability but there is no age-based pattern.
Hispanic women had the thinnest and black men the thickest aortas.
Hispidin , a metabolite of DK , strongly inhibited PAK1 with the IC50 = @number@ μM.
His sister carried the same gene defect and showed a similar type of TDP-43 / p62 pathology in her brain.
His symptoms improved after administration of adrenal and thyroid hormones and androgen.
His-tagged hLA was expressed in E. coli , and simple purification methods without any endopeptidase cleavage were designed.
Histamine dihydrochloride and IL-2 therapy had an acceptable tolerability profile in patients in the phase III trial.
Histamine dihydrochloride ( Ceplene® ) is a synthetic derivative of the biogenic amine histamine.
Histamine dihydrochloride inhibits the formation of reactive oxygen species that suppress the activation of T cells and natural killer ( NK ) cells.
Histaminergic neurons enhance cognition and memory , suggesting that their degeneration may contribute to the cognitive decline of AD.
Histiocytosis is rare but does occur in prevalent locations.
Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment.
Histological analyses revealed that vessels of the footpad tumor in VASH1 ( - / - ) mice were more immature , having fewer mural cells.
Histological analysis demonstrated increased dermal collagen ΙΙΙ.
Histological analysis demonstrates that , while tumour cell proliferation and vessel stabilisation are impaired , vessel permeability is increased in mice that produce mbKitL-targeting antibodies.
Histological analysis revealed corneal layer diminution , epidermal thickness increase , and elastosis reduction.
Histological analysis revealed multiple heart defects , including cardiomegaly , enlarged cardiac valves , ventricular noncompaction and ventricular septal defects.
Histological analysis revealed that porcine samples were composed of more elastin and less collagen fibers than the respective human samples.
Histological analysis showed focal damage that extended about @number@ μm deep to the surface.
Histological analysis suggested a broader effect , alongside sparing of the outermost epidermal layer with the SST versus NAFL treatment.
Histological and functional analyses showed that larvae at pre-metamorphic stages restore anatomical continuity of the spinal cord and recover swimming after complete spinal cord transection.
Histological and functional outcomes were measured at @number@ h after middle cerebral artery occlusion with fibrin clot.
Histological changes of mouse skin were analyzed by H & E staining.
Histological examination has also revealed profound microglial activation in diseased brains often in association with these fibrillar peptide aggregates.
Histological examination obtained from biopsy of the pituitary revealed lymphocytic
Histological examination on surgical preparations showed that in two cases it was a GIST and in one case , it was a leiomyoma.
Histological examination revealed increased epidermal thickening and decreased solar elastosis @number@ months after the final laser treatments.
Histological examination showed signs of granulation tissue in only @percent@ of cases , but no differences between the groups.
Histological examination showed three patterns of collagen arrangement ; parallel arrangement was found in over @number@ percent of specimens.
Histological examination was performed using biopsy samples taken at baseline ( pretreatment ) and @number@ months after the last treatment.
Histological findings showed @number@ pT2 and @number@ pT3 cancers.
Histological grade was determined according to the Mankin score.
Histological improvement was seen using stains for collagen , elastic tissue , and perifollicular fibrosis after MAL plus red light therapy.
Histologically , all cases displayed predominantly microcystic patterns , often a mixture of follicular and papillary-cystic structures.
Histologically , CA increased dendritic and synaptic markers , and decreased astrogliosis , Aβ plaque number , and phospho-tau staining in the hippocampus.
Histologically , severe neuronal loss and gliosis were evident in the spinal anterior horns.
Histologically , there was less evidence of photodamage in ETR than in TP , which had wispy collagen and solar elastosis surrounding blood vessels.
Histologically , the RPE contained prominent vacuoles in young DJ-1 KO group with the appearance of enlarged irregularly shaped RPE cells in the older group.
Histologically , they are epidermal tumors.
Histological samples were analyzed by light and electron microscopy and renal injury was graded.
Histological staining permitted quantification of microglial and astrocytic activity.
Histological studies indicate : decreasing of keratinization , regressive changes in epithelium and fibrosis in underlying connective tissue.
Histologic BPH was observed in a similar proportion of Asian and Caucasian men ( p = 0.94 ) .
Histologic evaluation confirmed the ligamentous features of the orbicularis retaining ligament.
Histologic findings corresponded to clinical improvement.
Histologic structures of the skin were evaluated by 3D images obtained using the 3DR technique.
Histology after tumor nephrectomy showed a mixed kidney cancer consisting of elements of a chromophobe renal cell carcinoma and dedifferentiated small cell carcinoma component.
Histology improved in patients with paired biopsy , but tissue HBsAg was present in all but one patient after @number@ months of therapy.
Histology is essential to precisely characterize the glomerular diseases underlying nonspecific clinical pictures and to direct the best therapeutic strategies.
Histology showed that single fibrin fibers or smaller protein clots within the ILT generate smooth dissected surfaces during the peeling.
Histology was assessed before and @number@ months after the third treatment.
Histology was available for @number@ patients and data of liver stiffness ( LS ) for @number@ patients at baseline.
Histology was done to test for amyloid plaque association and activation of the complement cascade.
Histomorphometric aging methods report varying degrees of precision , measured through Standard Error of the Estimate ( SEE ) .
Histomorphometric analysis revealed statistically significant thinning of the cutis , thickening of the subcutis and a degeneration of elastic and collagen fibers.
Histomorphometric studies led to sorting out the lesions due to aging from those stemming from hypertension.
Histomorphometry revealed reduced bone-formation and mineral apposition rates , accompanied by decreased osteoblast numbers.
Histone acetylation is an epigenetic modification that plays a critical role in chromatin remodelling and transcriptional regulation.
Histone deacetylase inhibitor MS-275 dose- and time-dependently increased Rorγt expression and subsequently enhanced Th17 differentiation.
Histone deacetylases ( HDACs ) catalyze the removal of acetyl-groups from lysine residues within nucelosomal histone tails and thousands of non-histone proteins.
Histone modifications have the ability to dictate chromatin structure and direct gene expression.
Histone modifications influence chromatin compaction and gene expression and undergo many changes during aging.
Histone modifications play crucial roles in modulating chromatin function and transcriptional activity.
Histone protein levels also decline during aging , dramatically affecting chromatin structure.
Histones are evolutionarily conserved DNA-binding proteins.
Histone ubiquitination plays major roles in chromatin regulation and DNA repair.
Histopathological changes in CE were further identified in paraffin tissue sections , whole-mount immunostaining , and scanning electron and transmission electron microscopy.
Histopathological evaluation demonstrated a foreign body reaction resembling the reaction against semi-permanent or permanent fillers such as poly-L-lactic acid or polymethylmethacralate.
Histopathological evaluation of the specimens with H & E staining all resulted in a definitive diagnosis of cemental / cementodentinal tears.
Histopathological examination of the biopsy specimens revealed septate hyphae with dichotomous branching small circular blastospores.
Histopathologically , most specimens revealed only bland scattered proliferation of atypical melanocytes without marked cellular atypia or dermal invasion.
Histopathologically , the adenomatous tumor was composed of large monomorphic cells with eosinophilic granular cytoplasm.
Histopathological studies in Alzheimer's disease ( AD ) suggest severe and region-specific neurodegeneration of the basal forebrain cholinergic system ( BFCS ) .
Histopathologic features of these lesions sometimes are not enough for a definite diagnosis and immunohistochemical studies may be required.
Histopathologic findings were nonspecific.
Histopathologic picture can enhance the accuracy of clinical diagnosis of various nail changes and disorders.
Histopathologic studies have revealed that inflammation , disorder of calcium and phosphorus metabolism and dyslipidemia are involved in the process of CAVD.
Histopathology analyses showed that mild osteoarthritic changes had occurred.
Histopathology classified @number@ lesions as CMIs , all of which were located intracortically.
Histopathology is the gold standard for classification and grading of brain tumors.
Histopathology revealed non-inflammatory actinic purpura.
Historical backgrounds of major dementia diseases are also addressed.
Historical , environmental , and cultural contexts intersect with aging , sexuality , and gender across communities and generations.
Historical events and personal experiences have the potential to alter the way people age.
Historical human mortality curves display five phases , differing in dimensions with population , time and circumstance.
Historically , nitrogen balance has been the dominating technique.
Historically , regulatory agencies started to promote the inclusion of older participants in clinical trials in the late 1980s.
Historically , the ageing process and its consequences were thought to be intractable.
Historically , the definition included symptom resolution within @number@ hours.
Historically , the patient call bell has been the mechanism by which patients can alert a health-care worker to provide help.
History of bladder , breast , endometrial / uterine , or prostate cancer was associated with higher prevalence of UI.
History of cardiovascular disease was a significant predictor of poor function , but the effect was similar across groups.
History of depression was associated with a @percent@ faster annual HcV loss in women ( @percent@ CI @number@ @date@ % ) .
History of disease , medication use , smoking status and alcohol use were recorded.
History of falling can be used to identify individuals at risk of MVC involvement and to begin a dialogue about driver safety.
History of falls was assessed via questions derived from the National Health and Nutrition Examination Survey questionnaire.
History of past depression and age of onset of symptoms were obtained from direct questioning and from electronic health record linkage.
History of postpartum and perimenstrual mood exacerbation and current hormone therapy were evaluated as potential mood predictors.
History of psychiatric hospitalization was associated with moderate or greater illicit drug symptoms ( adjusted odds ratio [ AOR ] = @number@ @number@.0-3.6 ) .
History of severe plegic / dystonic attacks was not found to be an aggravating factor for deceased patients.
History of systemic and ocular diseases was collected via standard questionnaire.
History of VTE , obesity , and / or poor strength independently predicted new VTE events.
HI titers at Days @number@ @number@ and @number@ populate @number@ biologically plausible profiles.
HIT perceived usefulness was related to establishing trends in health status , detecting early signs of infection and potential to self-manage.
Hitting one HDAC member could yield clinical benefit but this required a complete understanding of the functions of the different HDAC members.
HIV-1-infected adults over the age of @number@ years progress to AIDS more rapidly than adults in their twenties or thirties.
HIV-1-infected monocyte-macrophages traverse the BBB and enter the CNS throughout the course of HIV-1 disease.
HIV and Meth use had an interactive effects on depressive symptoms , but did not show additive or interactive effects on oxidative stress.
HIV and reduced physical performance have independent and joint effects on mortality.
HIV-associated heart failure remains a common cardiac diagnosis in people living with heart failure , yet a unifying set of diagnostic criteria is lacking.
HIV-associated immune activation and inflammation , promoting tumorigenesis , can only partially be reduced by HAART.
HIV-associated inflammation and immunosenescence have been implicated as causally related to the premature onset of other end-organ diseases.
HIV-associated mortality risk was calculated using the Veterans Aging Cohort Study ( VACS ) Index.
HIV-Associated Neurocognitive Disorder ( HAND ) is a prevalent condition among persons with HIV resulting in cognitive impairments that may impact daily functioning.
HIV-associated neurocognitive disorder remains prevalent in HIV-infected individuals despite effective antiretroviral therapy.
HIV-associated neurocognitive disorders ( HANDs ) are common , often go undetected , and can impact treatment outcomes.
HIV-associated neurologic complications encompass a wide spectrum of pathophysiology and symptomatology.
HIV-associated non-AIDS conditions were more prevalent in patients with longer HIV duration , whereas nT represented a protective factor for cancer and COPD.
HIV chronicity has resulted in increased life expectancy for many African American women who acquired the disease during the epidemic's peak years.
HIV clinical care now involves prevention and treatment of age-associated comorbidity.
HIV disease severity was ascertained using the VACS index , a validated measure of morbidity and all-cause mortality.
HIV duration and nT were simultaneously predictors of multimorbidity.
HIV has no known cure , but it can be controlled and sometimes prevented with proper medical care.
HIV / HCV coinfection appears to be protective against hypercholesterolaemia.
HIV-infected adolescents were @percent@ more likely to report illness than HIV-infected young adults.
HIV-infected adults ( ≥18 years ) who initiated ART were observed for first NCD occurrence between @date@ and @date@ .
HIV-infected adults had a greater risk of all @number@ outcomes compared with uninfected adults after accounting for important confounders.
HIV-infected adults have excess risk of cardiovascular , liver , kidney , bone , and neurologic diseases.
HIV-infected individuals have an increased risk of age-related morbidity despite antiretroviral treatment ( ART ) .
HIV-infected individuals have excess congestive heart failure ( CHF ) risk compared with uninfected people.
HIV-infected individuals suffer from accelerated aging , which manifests as premature cardiovascular and bone disease.
HIV-infected participants scored significantly lower than the HIV-negative group on all measures of NP testing and also reported receiving SSR at a higher rate.
HIV-infected patients are known to be at increased risk for persistent genital and anal high-risk HPV infections and intraepithelial neoplasm.
HIV-infected patients present lower BMD than non-HIV infected individuals and a higher prevalence of osteopenia / osteoporosis.
HIV-infected women were similar to control women at both time points.
HIV infection has also direct effects on mitochondria.
HIV infection has become a chronic condition with a life-long treatment.
HIV infection has gone from a death sentence to a manageable chronic disease which develops several decades.
HIV infection increases incidence and prevalence of all HPV-associated diseases.
HIV infection , itself , as well as multiple physiologic and psychosocial factors can contribute to cognitive impairment and neurologic complications.
HIV infection may also be associated with accelerated biological aging.
HIV infection may potentiate specific biomarkers that influence the development of premature clinical indices commonly associated with aging.
HIV infection , once considered a unique deadly infectious disease , has now become a chronic disease with efficacious highly active antiretroviral therapy.
HIV infection was associated with lower odds of outside hospitalization ( OR = @number@ [ @percent@ CI : @number@ @number@ ] ) .
HIV might play a role in HPV-associated pathogenesis by exhorting oncogenic stimuli via tat and rev or visa versa.
HIV-positive patients have impaired color vision and contrast sensitivity , which worsens with age.
HIV programmes are likely to reach older South Africans in home-based interventions where testing is not always feasible.
HIV providers may lack experience managing multimorbidity or the functional consequences of aging.
HIV-related and liver-related deaths were higher among older OUD compared to same-age peers without OUD.
HIV retinae also have increased macular retinal thickness that may be caused by inner retinal edema secondary to retinovascular disease in HIV.
HIV retinopathy is the most common non-infectious complication in the eyes of HIV-positive individuals.
HIV services need to be better targeted to respond to the growing needs of older adults living with HIV.
HIV stigma in older Black women may be compounded by preexisting social inequities based on gender , age , and race.
HIV testing and screening programmes and safer sex initiatives often exclude older sexually active WLHIV.
HIV viral load , hepatitis C coinfection , and serum alkaline phosphatase were inversely associated with eGFRCYSC.
HIV was an underlying factor in the majority of adults with infections and was also present in @percent@ of those with NCDs.
HIV was primarily associated with differences in measures of centrality , and age was primarily associated with differences in diversity.
HI was defined as pure-tone average > 25 dB HL in the better ear.
HLA antigen expression was evaluated by flow-cytometry.
HLCs derived from hESCs and human iPSCs exhibited broad similarities but as well meaningful differences.
HLCs derived from hESCs and human iPSCs showed significant functional similarities , similar expression of genes important for liver physiology and common pathways.
HLE65 calculated according to ADL and mobility limitations increased more rapidly than LE65 for both men and women ( p < 0.05 ) .
HL is a broader concept than HE.
HME was linked to better memory function ( p = @number@ ) , mediated by larger hippocampal volume ( p = @number@ ) .
HMGB1 causes activation of nicotinamide adenine dinucleotide phosphate oxidase and increased reactive oxygen species production in neutrophils.
H / M-ratio was measured at @percent@ of maximal M-wave ( H / M20% ) @number@ @number@ and @number@ ms after perturbations.
HNE can react covalently with Cys , His , or Lys residues on proteins , altering structure and function of the latter.
HNE-treatment also reduced the LADH activity in mice brain.
HNE was increased in the chronically sunlight-exposed skin but not in the sunlight-protected skin.
H ( @number@ ) O ( @number@ ) alone or in combination with LPS also moderately enhanced TF expression.
HO-1 and HO- @date@ have different mechanisms to protect neurons from oxidative stress.
HO-1 can be induced mainly in microglia and astrocytes by oxidative stimulus rapidly.
HO-1 is normally barely detectable in the brain.
HO-1 might function as an emerging molecule to protect neurons against acute insults mediated by facilitating iron efflux from cells under stress conditions.
HO-1 mRNA expression was detected by real-time PCR.
HO-2 could protect neurons through bilirubin pathway.
HO-2 might also promote neuronal survival through the CO-cGMP-MAPK pathway.
HO-2 predominantly expressed in neurons.
HOA decreased from childhood to early adulthood and then increased with age , as modeled by a second-order polynomial regression.
Hoarding interventions with older adults require significant resources from multiple public agencies , yet recidivism occurs frequently.
Hoarding severity significantly predicted the total number of medical conditions.
Hoarding symptoms and the resulting clutter may exacerbate health conditions and lead to improper management of medical illnesses.
HO- @date@ confer neuroprotection or neurotoxic effect because of the balance between beneficial and toxic effects of heme and heme products.
Hoechst @number@ staining was conducted to confirm the detection of cell apoptosis.
Hoffmann reflexes ( H-reflexes ) and compound muscle action potentials ( M-waves ) were also evoked via electrical stimulation of the peroneal nerve.
HO is known to abate apoptosis and necrosis , and improves cell vitality , which in turn , may enhance tissue regeneration.
Holistic care culture ( HCC ) was proposed as an organizational culture of holistic caring.
Holistic memory training seems to be impactful for older adults.
Holocaust survivors are at increased risk of osteoporosis , cardiometabolic disease due to axis dysfunction , cancer , and sequelae of Nazi medical experiments.
Holocaust survivors did not differ in the level of resilience from comparisons ( mean : @number@ ± @number@ vs. @number@ ± @number@ respectively ) .
HOMA-IR did not mediate the association between ox-LDL and MS components.
HOMA-IR seems to have a stronger influence than SBP on arterial stiffness.
Home-based nursing pulmonary rehabilitation can be an effective , inexpensive and accessible programme for decreasing fatigue and improving ADL and QOL for patients with COPD.
Home-based providers documented visits with participants , contacts to and responses from primary care personnel.
Homebound older adults constitute a \ "hardly reached \ " population with respect to health communication.
Homebound prevalence rates of @date@ @percent@ were found.
Home-care assistants have practical administration skills , but lack formal medical knowledge.
Home care for dementia is said to be more difficult than palliative care at home for patients with terminal cancer.
Home CGA programs and CGA performed in the hospital were shown to be consistently beneficial for several health outcomes.
Home healthcare clinicians are in a position to promote patient safety by educating these patients about the devices available for those with decreased vision.
Home healthcare clinicians may find understanding Veteran's health benefits intimidating and may falsely assume that a Veteran is aware of his or her benefits.
Homeless individuals have a higher prevalence of substance use disorders than the general population.
Homemakers may be more active than employed women ( EW ) .
Home modifications , when delivered by occupational therapists , can reduce falls among high-risk community-dwelling older adults by @percent@.
Homeobox transcription factors are key intrinsic regulators of myogenesis.
Homeostasis is a key feature of cellular lifespan.
Homeostasis is one of cardinal properties of the organism , which arises in evolution basing on mechanisms maintaining stationarity.
Homeostasis model assessment for insulin resistance was calculated and used as a marker of insulin resistance.
Homeostasis model assessment of insulin resistance ( HOMA-IR ) was calculated.
Homeostasis model assessment of insulin resistance was used in Asians.
Homeostasis model assessment of IR ( HOMA-IR ) was used as an IR index.
Homeostasis of the skin is maintained because these stem cells collaborate with each other to form new cells.
Homeostatic disinhibition may be the major mechanism that activates cognitive reserve.
Homeostatic model assessment was used to quantify insulin resistance.
Home repair service users were less likely to perceive the need for relocation.
Home size and physical function were primary predictors of the number of steps taken at home , as found using a general linear regression analysis.
Home visit capacity should be explored as a possible source of heterogeneity and potential bias in genetic studies.
Home visits by the nutritionist were convenient and participants felt that someone cares.
Home was experienced as the place the older adult could not imagine living without but also as the place one might be forced to leave.
Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models.
Homocysteine , cysteine and glutathione total levels were determined by using HPLC with electrochemical detection.
Homocysteine elevation has emerged as a prothrombotic factor , influencing coagulative status and endothelial function and potentially modulating platelet aggregation.
Homocysteine elevation was associated with faster decline in executive function.
Homocysteine levels were divided into quartiles for each site.
Homocysteine was independently associated with the observed effect of diabetes on executive function.
Homodimers are abundant , although it is possible that complexes consisting of Col28a2a and Col28a1a or -a2b occur.
Homogeneity of the associations was also assessed.
Homogeneity of the cohort sample ( intelligent , mostly White ) limits generality but provides natural control of common confounds.
Homogeneous vitreous degeneration ( liquefaction ) , but not partial posterior vitreous detachment , greatly increases oxygen exposure to the lens.
Homogenous criteria have been addressed in reviews of other Alzheimer's disease biomarkers.
Homologous recombination ( HR ) is necessary to counteract DNA replication stress.
Homologous recombination is a universal process , conserved from bacteriophage to human , which is important for the repair of double-strand DNA breaks.
Homologue DTI-derived FA maps were only partially overlapping with GFA maps.
Homonymous visual field disorders ( HVFD ) are frequent and disabling consequences of acquired brain injury , particularly in older age.
Homozygosity for the common nonsense polymorphism R577X in the α-actinin-3 gene ( ACTN3 ) causes complete α-actinin-3 deficiency in fast-twitch skeletal muscle fibers.
Homozygotes for the H1 haplotype showed about twice the risk of metabolic syndrome in both males and females ( p < @number@ ) .
Homozygous mutations in exon @number@ of TREM2 , a gene involved in Nasu-Hakola disease , can cause frontotemporal dementia ( FTD ) .
Homozygous SMN1 loss causes spinal muscular atrophy ( SMA ) , the most common lethal genetic childhood motor neuron disease.
Honesty-humility showed a pronounced and consistent increase across the adult life span.
Honey-based cosmetic products include lip ointments , cleansing milks , hydrating creams , after sun , tonic lotions , shampoos , and conditioners.
Honey is a broad spectrum antimicrobial agent which can enhance wound healing.
Honey's unique antibacterial , anti-inflammatory , and antioxidant properties were shown to contribute to wound healing , especially in ulcers and burns.
Hopefully this will open new opportunities for the prevention and management of dementia and AD.
Hopefully , this will provide a practical and clinically useful approach to a large and diverse assortment of genetic skin conditions.
Hopelessness and anxiety remained significant in combined model ( p < @number@ p < @number@ respectively ) even when motor score was included.
Hopelessness and anxiety showed a particularly strong association with SI.
Hopelessness did not act as a mediator.
Horizontal cleavage tears ( HCT ) commonly occur in the posterior horn of the medial meniscus due to aging and degeneration.
Horizontal hemifield defects or other optic nerve-field defects were associated with thinner NFL.
Horizontal relative disparity thresholds for 4- to 7-year-old children were comparable with those of adults at ∼0.5 arcmin.
Hormesis ( exemplified in ischemic preconditioning ; IPC ) and expression of proteins influencing signaling / stress-resistance were also assessed in mice.
Hormonal abnormalities , anovulation , and hyperandrogenic signs were predominant during the early years of PCOS and fade away with the years.
Hormonal and hematologic responses were similar in anemic participants.
Hormonal changes and other physiological changes associated with aging affect sexual interest.
Hormonal , genetic and inflammatory mechanisms are known to increase the risk of hand OA and influence the course of the disease.
Hormonal levels were categorized into quartiles , and ratio of IGF-1 to IGF-binding protein ( IGFBP ) -1 was calculated.
Hormonal shifts at menopause alter vascular function putting women at risk for both hypertension and WMH.
Hormone activity may change with age as a result of reduced hormone secretion or decreased tissue responsiveness.
Hormone concentrations were not significantly related to mood.
Hormone decline is common to all women during aging and , associated with other factors , leads to cognitive impairment.
Hormone receptor-positive disease is best treated with adjuvant endocrine treatment ; aromatase inhibitors and tamoxifen are both options.
Hormone replacement therapy ( oral and nonoral ) and transdermal estrogen therapy represent possible specific managements for women engaged in the climacteric phase.
Hormone therapy begun in this older postmenopausal group does not ameliorate cognitive aging.
Hormone therapy has adverse effects on the brain as manifested by higher risks of stroke and dementia.
Hormone therapy has been approached in several clinical trials.
Hormone therapy ( HT ) reduces frequency and severity of hot flashes , prevents bone loss and osteoporotic fractures , and relieves vaginal atrophy.
Hormone therapy is no longer recommended due to an increase in adverse events ( most consistently seen as increased ischemic stroke risk ) .
Horn length did not affect hunter selection , but we found a strong hunter preference for nonlactating females.
Horn length , however , may also be a criterion used by hunters in selecting animals to harvest , possibly leading to artificial selection.
Hosmer-Lemeshow test was performed.
Hospice is a major expansion area within the Veterans Health Administration ( VHA ) .
Hospice patients with transitions accrue higher costs.
Hospice programs have emerged over the last @number@ years as both an effective and humane practice for responding to terminal illnesses in the free society.
Hospice referral , frequency of pain and dyspnea , and treatment of these symptoms was ascertained.
Hospices ' bereavement services could potentially address needs of many at risk , but little is known about their service use.
Hospices were surveyed about availability and sources of internal funds and referral to obtain basic social supports for patients.
Hospital admission records and cause of death registries ( ICD-9 and ICD-10 codes ) were available until @date@ .
Hospital admissions are too brief for patients to regain necessary function.
Hospital and SNF ratings of potential avoidability agreed for @percent@ ( @number@ of the @number@ readmissions ) , but readmission factors varied between settings.
Hospital billing data were used to compare inpatient costs , transfusion rate , and rate of advanced imaging utilization.
Hospital characteristics were obtained from the American Hospital Association database.
Hospital death was least likely in the Netherlands compared with other countries.
Hospital discharge and the planning of follow-up visits are critical for therapeutic recommendations.
Hospital functions should be redesigned to account for the large and growing role of surrogates , supporting them as they make health care decisions.
Hospital inpatient costs contributed @percent@ of total costs for prevalent dementia and accounted for differences between CN and both prevalent and newly discovered dementia.
Hospitalisations in this population are often by acute admission and through the emergency department.
Hospitalists face the challenge of balancing the aforementioned risks ; the optimal management of these patients requires knowledge of the relevant literature and expertise.
Hospitalization and Medicare expenditures data ( 1999-2010 ) were obtained from Medicare claims.
Hospitalization and mortality rates were evaluated during an 11-year follow-up.
Hospitalization can lead to loss of independence and also need for long-term care at discharge.
Hospitalization data were obtained from Part A Medicare beneficiary records.
Hospitalization expenditure was significantly associated with length of stay , operation , etc.
Hospitalization experience and lifestyle factors are associated with skin hydration.
Hospitalization rate calculations and descriptive analyses were performed on variables associated with the burden of hospitalization and compared with the adult age group.
Hospitalization rates among United States Veterans were calculated and stratified by HIV serostatus and principal diagnosis disease category.
Hospitalizations for hip fractures were comparatively stable ( @percent@ in women and @percent@ in men ) .
Hospitalizations , older age , previous stroke , lower cognition , and osteoarthritis were risk factors for decline among prefrail participants.
Hospitalizations , older age , previous stroke , lower cognitive function , diabetes , and osteoarthritis were associated with worsening or less improvement.
Hospitalizations that included ICD-9-Clinical Modification codes for a fall and an injury were identified.
Hospitalization was also less common among residents for whom recommendations were followed.
Hospitalization was assessed with logistic regressions ; cumulative length of stay , with zero-truncated negative binomial regressions.
Hospitalization was associated with strength declines in men ( @number@ Nm , P = @number@ ) but not in women.
Hospitalization was determined via linkage with the provincial Inpatient Discharge Abstract Database.
Hospital managers have a leading role in creating system-wide falls prevention programs and reducing hospital costs.
Hospital mortality for sepsis admissions was @percent@ and overall , @percent@ of the included patients died while hospitalized for sepsis.
Hospital mortality was @percent@ ( @number@ patient ) .
Hospital readmissions accounted for @percent@ of costs.
Hospital readmissions represented @percent@ of total inpatient costs , and having Medicare or Medicaid before ALI was associated with increased costs.
Hospitals are using non-slip socks as an alternative footwear to help prevent falls , however there is limited evidence to support their use.
Hospitals , health professionals and users may feel torn within a system that tends to simplify and minimize what is becoming increasingly complex and global.
Hospitals should follow this example because the competition for qualified staff members is increasing rapidly.
Hospital staff ascertain and enroll patients discharged home with a clinical diagnosis of stroke or transient ischemic attack.
Hospital staff , including management , needs to work towards optimizing nutrition care in hospitals to improve the prevention , detection and treatment of malnutrition.
Hospitals were ranked based on risk-adjusted excess readmission ratios.
Hospital volumes rose slightly for aortic-valve replacement but fell for coronary-artery bypass grafting and carotid endarterectomy.
Host factors and duration of HIV infection are associated with increased risk of MM compared to the general population.
Host predisposing conditions are immunosuppression , intravenous drug use , a variety of chronic underlying diseases and prior surgical interventions.
HOTAIR levels are highly upregulated in senescent cells , causing rapid decay of targets Ataxin-1 and Snurportin-1 , and preventing premature senescence.
HOTAIR transcription is regulated by HIF1α which binds to the hypoxia response elements ( HRE ) present in the HOTAIR promoter under hypoxia.
Hot flashes decreased slowly after menopause and did not return to premenopausal levels until @number@ years after the FMP.
Hot flashes were detected objectively through sternal skin conductance and by patients via electronic event marking.
Hot flushes / sweating were the only symptoms specifically assigned to the menopausal period.
Hot flushes were evaluated at 9-month to 12-month intervals through in-person interviews.
Hourly rounding is supported by the literature as an effective strategy for falls prevention and patient safety.
Hourly temperature data were obtained from the Boston Logan Airport weather station ( located approximately 12km from the clinical site ) .
Hourly temperature , windchill , humidity , and snowfall accumulation were obtained from meteorological records and time locked to hourly accelerometer PA values.
Hours of unpaid care are not substantially lower when paid care is also received.
Household chores load was assessed by hours spent on such chores.
Household composition was flexible and responsive to changing needs of multiple generations but family finances were stretched.
Household disorder and street disorder partially accounted for educational disparities in physical capacity.
Household income and education level did not have any significant association with the likelihood of a hardcore smoker.
Household income-to-poverty threshold ratio was also associated with LTL ( b = 0.05 , SE = 0.02 , p < 0.01 ) .
Households consequently contribute more to their DC plans than they would absent the borrowing option.
Household surveys were performed and water samples were collected from community water sources.
Housework was negatively associated with Latinas ' emotional health and Caucasians ' cognitive functioning.
Housing and social support are important determinants of health.
Housing satisfaction was discussed as potential indicators of quality of life.
How accurate are children when dating very long-term memories ?
How aging influences this relationship is a matter of great interest.
How a model is assembled and the different theoretical frameworks that can be used to build a model are also discussed.
How and the extent to which they change due to natural aging is not fully understood.
How are longitudinal measurements affected by aging ?
How best should OCT be used alongside visual fields , and how often should OCT be performed ?
How best to design , integrate and deliver these programs are unknown.
How best to manage the multiple comorbidities and polypharmacy that are common in individuals wtih HIV has not been studied.
How can changes resulting from aging be differentiated from true progression ?
How can this apparent disconnect be explained , and what can be done about it ?
How can we approach their health promotion ?
How CFTR deficiency predisposes to diabetes is unknown.
How deficits are expressed differs between the sexes , with important implications for interventions strategies.
How did our ancestors grow ?
How did single-celled organisms coalesce to produce many-celled forms that evolved and diversified into the varied multicellular organisms in existence today ?
How disk degeneration and lumbar spine motion relate to SNs is poorly understood.
How do acoustic challenges influence this allocation of attention , and to what extent is this ability preserved in normally aging listeners ?
How do aging and prior knowledge affect memory and metamemory ?
How do elevated levels of lamin B1 cause disease and why is the CNS particularly susceptible to lamin B1 fluctuations ?
How does aging impact search processes in such disparate situations ?
How does cognitive control change with age , and what are the processes underlying these changes ?
How does neuroplasticity science inform us about optimal therapeutic program designs ?
How does one relate to it ? '
How does the brain assign responsibility to each of these potential actors ?
How does the brain support these age-related improvements ?
How does this prescription relate to concurrent medication ?
How does understanding the decimal system change with age and experience ?
How do mammalian tissues and organs develop , maintain their architecture , become subverted in disease , and decline with age ?
How do older workers keep up and adapt to a changing workplace after age @number@ ?
How do other people around the world grow ?
How do people think about time ?
How do species avoid accumulating damage when composed of individuals that do ?
How do such cognitive heterogeneities occur ?
How do such individuals experience and make sense of their multilingualism ?
How do they want to be remembered ?
How do we choose which technology is best for our patients ?
How do you handle peels in advanced Fitzpatrick skin types III , IV , V ?
How do younger and older adults remember reputational trait information about other people ?
However , 18F-florbetapir retention values in the posterior cingulate gyrus inversely correlated with verbal memory performance.
However , 24-h measurements may be variable due to critical illness related factors and a circadian rhythm could be present.
However , 30-day and 1-year mortality continued to be high.
However , 7KCh formed in situ , usually associated with lipoprotein deposits , can adversely affect surrounding tissues by causing inflammation and cytotoxicity.
However , A50 : P50 MTH ratio was not significantly correlated with aLM and aLM index in both sexes.
However , ABCA7 expression is increased in AD individuals.
However , aberrant up-regulation of this metabolic pathway contributes to the progression of glucose intolerance in individuals with diabetes.
However , abnormalities in the pharyngeal phase in SCA6 were indistinguishable from those in SCA3 , with no explainable reason.
However , abnormalities in visual function have been reported in HIV-infected individuals despite effective viral suppression and the absence of retinal OIs.
However , abnormal midbrain / pons values suggestive of PSP have also been reported in elderly individuals and in patients with PD.
However , about @percent@ of patients experienced profound changes in vital signs of > 20% above baseline during LEMG.
However , absent is evidence from larger studies , which allow better statistical adjustment for confounding and mediating factors , in more representative samples.
However , a causal link between telomere shortening and diabetes risk has not been established.
However , accepting and celebrating the autumn of life means firstly understanding old age for what it is : the sign of our human condition.
However , access to treatment has declined or remained largely unchanged in some countries.
However , according to recent studies , there may be dissociations among different types of implicit memory.
However , accounting for observed selection biases , significant associations were found linking longer retirement with more rapid cognitive decline.
However , accruing epidemiological and clinical trial evidence in older humans suggests that this is not the case.
However , accumulating evidence has implicated the pathogenesis of several human diseases including neurodegenerative disorders related to increased oxidative stress.
However , accumulating evidence indicates that telomerase reverse transcriptase may have fundamental biological functions independent of its enzymatic activity in telomere maintenance.
However , accumulating evidence indicates that TERT may also have some fundamental functions that are independent of its enzymatic activity.
However , accumulating recent evidences show that there are conflicting data regarding beneficial effects of statins on progression of cardiovascular calcification.
However , accumulation of senescent cells in tissues during aging contributes to age-related pathologies.
However , accuracy of recall was slightly better on a list compared to the others.
However , achieving ≥20 min / day in MPA bouts resulted in improved FMD%.
However , a clear distinction between AD-specific gene expression changes and those resulting from nonspecific responses to toxic aggregating proteins has not been made.
However , a clinical phenotype of aging exists that is experienced by all living individuals and is pervasive across multiple physiologic systems.
However , a closer look at components of stress vulnerabilities and depression is required to allow for the development and testing of appropriate interventions.
However , a comorbid condition of VHD and CAD has not been precisely examined.
However a comparatively limited amount of data is available to verify whether these processes also contribute to normal aging within the brain.
However , a compensatory increase in sympathetic outflow was seen in young patients.
However , a comprehensive analysis of multidomain cognitive associations with hippocampal deformations among a large group of cognitively normal older adults is currently lacking.
However , a contribution of renal dysfunction to psychosis associated with cognitive decline remains to be investigated.
However , ACS and other diagnoses should be considered in patients with a negative CWT test.
However , activated astrocytes also appear to be capable of generating ROS.
However , activation of cytoprotective autophagy overcomes antiproliferative effect of the inhibitors and develops drug resistance.
However , actual occurrence of excessive intraorbital fat herniation is still controversial.
However , adaptability in growth hormone response was associated with larger training-induced gains independent of age.
However , \ "adaptive decoupling \ " of the life stages during metamorphosis may resolve ontogenetic conflict and facilitate independent adaptation to both environments.
However , additional research is necessary to clarify the roles of individual HDACs in memory.
However , additional studies are necessary to further investigate the role of exercise intensity in these results.
However , addition of TNF-R1 to the previously validated Health ABC HF risk model did not demonstrate material improvement in net discrimination or reclassification.
However , a debate exists for their upper age limit.
However , a debate still exists on the positive role of androgens on human health , especially in women.
However , a decline in corpus callosum function cannot be excluded.
However , a definitive conclusion cannot be drawn from the available data.
However , adequate levels of fluidity are essential for the proper functioning of biological membranes.
However , a detailed analysis of disease-related geometric adaptations of the metacarpal shaft is missing.
However , a detailed neuromuscular assessment appears feasible only in a subset of participants.
However , a detailed quantification of human aortic root structural compliance , particularly in different regions , has been incomplete.
However , AD group exhibited worse Everyday Memory and Everyday Visuospatial abilities than the FTD group.
However , a difference in the direction of the %bilateral deficit occurred between the two age groups.
However , a different perspective has to be brought in when dealing with spirituality issues of ageing Muslims.
However , adipokine dysregulation is paradoxically associated with lipodystrophy and lipoatrophy with aging.
However , adiponectin and its receptors are expressed by different cell types of the male gonad , including Leydig cells , spermatozoa , and epididymis.
However , adiponectin was positively correlated with endothelin-1 ( p = @number@ r = @number@ ) .
However , a direct comparison of efficacy of IPDE @number@ and alpha-blockers or 5-alpha-reductase inhibitors is not yet available.
However , a direct proof of DNA replication in these cells has been missing.
However , adjusting for BMI attenuated this association [ HR : @number@ ( @percent@ CI : @number@ @number@ ) ] .
However , adjustment for education and income levels reduced most differences between groups.
However , adjustment for influential factors and exclusion of L supplement users removed differences of mean MPOD between ARM stages.
However , a dose-dependent increase in stem cell numbers was independent of both age and the nature of the insult.
However , a dysregulated vascular regeneration appears to play a key role.
However , a forced 3-factor structure explained @percent@ of the variance.
However , AF recurrence after CA remains a relevant clinical issue.
However , after additional adjusting for puberty , results were not different from controls.
However , after adjusting for confounders , sKlotho was not independently associated with the presence of CVD or the AACscore.
However , after adjustment for aBMD , all microarchitectural parameters became nonsignificant.
However , after adjustment for race and ethnicity , no states had ARRs that varied significantly from @number@
However , after correcting for multiple comparisons , no results remained significant.
However , after excluding participants with possible cognitive impairment , all of the dedifferentiation effects were attenuated to nonsignificance.
However , after many years of research , the debate over the exact pathways by which FGF23 may lead to increased CVD still continues.
However , after mutual adjustment for these factors , the difference in grip strength between settings remained significant.
However , after @number@ years , the separate and joint exposures did not predict MSDs.
However after stratifying by median homocysteine levels , this relationship remained only in the higher homocysteine stratum.
However , after the aforementioned adjustment , the statistical significance disappeared ( P for trend = @number@ ) .
However , after therapy was increased the CRP and fibrinogen may mean that anti-VEGF contribute an alteration of endothelial homeostasis in exudative AMD.
However , after treatment , orchidectomy had caused significant elevation of CTX compared to normal control rats.
However , after treatments a signi cant temperature elevation over @number@ hours with manageable erythema was noted with the fractional optic.
However , a full understanding of the etiology and pathogenesis of the disease has remained elusive.
However , a gap exists in translating this knowledge to bedside decision making.
However , age acceleration does not associate with decline in these measures , at least over a relatively short follow-up.
However , age alleviated the protective effects of rinse.
However , age and comorbidities might substantially moderate the pattern of differences.
However , age and gender patterns often differed for sleep characteristics that were both asked and measured , such as sleep duration.
However , age at diagnoses does not predict progression in LRRK2 parkinsonism.
However , age at interview , ethnicity , parent education , and depressive symptoms did not predict the pattern of onset of drinking.
However , age attenuates the effects of obesity on hypertension as the senior adults continue to age.
However , age-dependent changes in muscle mass and the visceral fat area have not been well documented in Asian populations.
However , age-dependent reference values for distinct B cell populations have rarely been reported.
However , age differences in choice behavior may be reduced if older adults can recruit additional neural resources that support task performance.
However , aged patients had more comorbidities.
However , aged rats displayed long-term changes in affective behavior and had increased microgliosis in the CA1 hippocampal region following surgery.
However , age effects on brain function and cognition differ across individuals.
However , age , female gender , emergent status , and prolonged cardiopulmonary bypass time were independently associated with death despite risk-adjustment.
However , age impacted on several leptin-cardiovascular risk relations ( interaction P < @number@ ) .
However , ageism and negative attitudes toward old age still need to be addressed.
However , age is the main risk factor for neurodegenerative disorders such as Alzheimer's disease ( AD ) that impact on cognition.
However , age is the only patient characteristic currently recognized to be predictive of long-term ovarian function after chemotherapy.
However , age modified the effect of glucose status such that differences between the groups diminished with advancing age.
However , a general model that accounts for the formation and evolution of these various surface-instability patterns still does not exist.
However , age of first bilingual exposure does matter.
However , age-related changes are likely multifactorial , and the relationship between neural changes and cognitive measures is not well-understood.
However , age-related changes in functional networks constructed via positron emission tomography ( PET ) data are still barely understood.
However , age-related changes in offset analgesia ( offset ) , a form of temporal pain inhibition , remain poorly characterized.
However , age-related changes in symptom presentation raise questions about the clinical significance of these symptom clusters in later life.
However , age-related changes to immunity are not completely understood.
However , age-related deficits were distinct between children and older adults.
However , age-related differences in this study could also reflect a compensatory strategy by older adults to ensure stability while performing this task.
However , age-related disparities persist , despite clinical trial evidence that treatment in older adults with chronic leukemia can be safe and effective.
However , age-related immune deficits in elderly people , known as immunosenescence , might contribute to increased disease burden.
However , age-related pulmonary changes may negatively influence the delivery of inhaled medications to the small airways.
However , age should no longer be considered as the sole determining factor in diagnostic and therapeutic decisions.
However , age was associated with reduced WE ( @number@ P < @number@ ) .
However age was negatively correlated with the levels of FT and AR.
However , aging and spontaneous differentiation of MSCs during culture expansion dampen their effectiveness.
However , aging has been repeatedly shown to be associated with resistance of muscle to the anabolic effects of feeding.
However , aging-in-place is not always a choice.
However , aging is also associated with heart disorders such as diastolic dysfunction that are not necessarily linked to the risk factors for cardiovascular diseases.
However , aging is also associated with increased between-subject variability.
However , aging is also linked to the pathogenesis of a number of complex diseases.
However , aging is associated with alterations in several key pathways and genes in humans that may contribute to the observed impairment in bone formation.
However , aging is sometimes associated with decreased taste sensitivity , also known as hypogeusia.
However , aging itself is categorized as one of the alarm symptoms in the diagnosis of IBS that may warrant further investigation.
However , aging per se does not alter the pharmacokinetics of commercially available insulin and its analogues.
However , a higher self-reported use of ADHD medication in the exposed group could suggest a difference in attention not revealed by the applied test.
However , akin to the former study we evidenced a significant relationship between a power increase in the β-bands and tinnitus-related distress.
However , a lack of accuracy or technical problems hampered the introduction of these DNA-based methodologies in casework analysis.
However , a lack of trials investigating outcomes in older populations ( ≥ @number@ years ) was noted in this review.
However , a large amount of variation exists in its efficacy.
However , a large degree of individual variation was found and arterial stiffness adaptations appeared positively related to the initial stiffness values.
However , a large part of the mechanisms for MQC remains unknown.
However , a large prospective randomized study is needed to confirm the conclusion.
However , a larger field of anhidrotic effects was found for DYS.
However , Al did not alter the recognition memory and β-amyloid plaque loads of Tg2576 mice.
However , aligning these morphological changes with chronological age has proven problematic , often resulting in biased age estimates.
However a link between these abnormalities and an increased acid oesophageal exposure has not yet been demonstrated in the elderly.
However , alleviation of bothersome symptoms is possible with the understanding of its patho-physiology and individual-based approach to treatment and expected outcome.
However , all fatiguing exercises induced similar alterations in postural stability , which was unexpected considering previous literature.
However , all IPL-ALA-PDT-treated sides showed adverse effects such as erythema and pain.
However , all measurements remained higher ( @date@ @percent@ ; p < 0.05 ) than in pre-training levels.
However , all the Masters age-group records improved significantly over time.
However , all the senescent features occurred at the earlier passages in elderly compared with younger patients.
However , all these three notions can be disputed.
However , all these trials have demonstrated either no benefit or even deleterious effects.
However , almost @percent@ were at risk of malnutrition , especially women and participants over the age of @number@ y.
However , almost the same amount of time was spent in the community for both studies.
However , a long-term structured PA intervention did not completely eliminate overall declines in total daily activity experienced by mobility-impaired older adults.
However , altered phosphorylation of TDP-43 may be more highly associated with aging than the levels of TDP-43 expression.
However , although convenient in its simplicity , the resting state is essentially an unconstrained paradigm with minimal experimental control.
However , although @percent@ would decide to do it again , the majority ( @percent@ ) would prefer to do it at a younger age.
However , although the efficiency of repair systems is assumed to be rather high , it is less than @percent@.
However , although the phosphorylation of tau by ERK1 / 2 has been demonstrated in cell-free system , it remains controversial in vivo.
However , although the study intervention included strength training , only a few selected studies assessed the improvement of muscle strength.
However , although Wolbachia shortens the lifespan , it also gives a breeding advantage which results in complex population dynamics.
However , a means of measuring community confidence in these measures has not been established.
However , a mechanistic or an observational connection between them has never been investigated in the disease.
However , a meta-analysis of published studies suggests a need for reappraisal.
However , AML is a leading cause of childhood cancer mortality.
However , among institutionalized elderly , the associations between use of AEDs and psychotropics showed a mixed pattern.
However , among institutionalized seniors , men are at higher risk for hip fracture.
However , among persons with AD a lower proportion of perceived access to the technology was described , as well as for persons with MCI.
However , among the identified regions of interest , we did not observe significant between-group differences in the hemispheric asymmetry of phonetic-MMNm.
However , among these older populations , little is known about what factors influence their eHealth literacy and use of Web @number@ for health information.
However , among the sub-group with activity limitations , loneliness was higher in @number@ compared with @number@
However , among those with higher dispositional cognitive reappraisal , older age was related to smaller pupil dilation for the negative image.
However , among wild Ache cancer is virtually unknown in non-elderly subjects , and only among older individuals are there deaths attributable to oncological diseases.
However , a more acute role of IGF-1 in current depression , as indicated by the cross-sectional results , may be possible.
However , ample recent literature indicates that the functions of ghrelin go well beyond its role as an orexigenic signal.
However , AM₂ receptors reportedly play an important role in maintaining a normal body weight in old age and may be involved in immune function.
However , amyloid peptides accumulation is currently seen as a key step in the pathogenesis of AD.
However , an age-related alteration of antioxidant ( AO ) system in radiation response in humans is poorly investigated.
However , an age-related difference in acquisition strategy is visible.
However , analysis of stem-completion times showed that explicit contamination during the task was unlikely.
However , analytical techniques used for measurement of muscle mass in young subjects may not be valid for use in the elderly.
However , an appropriate combination of different tools could lead to integrative analyses that would furnish new insights not accessible through one-dimensional datasets.
However , an association of the PGC-1α rs8192678 GG variant with longevity was seen in control subjects ( p = 0.019 ) .
However , anatomic pathology biorepositories store mostly frozen tissue rather than nucleic acids.
However , anemic comorbidity attenuates the adaptations of cerebral / muscular hemodynamic responses to exercise following this regimen.
However , an enzyme responsible for such a role has not been identified.
However , an exclusively pathological role for Aβ is being challenged by new evidence for an essential function of Aβ at the synapse.
However , an expanding and aging population contributed to continued high numbers of incident cancers in the HIV population.
However , an increase in new vertebral compression fractures at non-treated levels following augmentation is of concern.
However , an indirect effect of an emotion-centred coping strategy was not shown.
However , an isolated chronic CRP elevation could predict a decrease in aerobic fitness and insulin resistance installation in elderly individuals.
However , ankle dorsiflexion ROM was a significant explanatory variable for FRT alone.
However , an observed variation in the rate of this decline has raised the possibility of slowing or delaying age-related kidney disease.
However , another approach based on stimulation of endogenous antioxidant defense pathways is more original.
However , another kind of tradeoff may exist with PUFAs , at least for men.
However , a novel rare heterozygous sequence variant ( p.Q140H ) of uncertain significance was identified in FUS in both siblings.
However , an overload of free iron is toxic , inducing oxidative stress and cell death.
However , antigenic targets of inhibitory antibodies were not stable and changed substantially over time in most individuals , independent of age.
However , antioxidant therapy could be harmful if the improper compound or dose is employed.
However , a number of challenges remained to be solved in the future.
However , a number of hurdles still need to be overcome before immunosuppressive drugs can be safely withdrawn in solid organ transplant recipients.
However , a number of recent studies have demonstrated that UVA can also cause burning , elastosis , and skin cancer.
However , a number of studies in the past few years have documented important functions for lncRNAs in human diseases.
However , any benefit from such procedures has not been objectively evaluated and validated.
However , any model which does not take into account the effects of activity will not adequately describe the inherent ageing process.
However , any such treatment must be started early in the disease.
However , APACHE II performs better than ATN-ISI.
However , a paradoxical change in the fast pathway ERP was noted.
However , apathetic , depressed older adults adopted an advantageous strategy and selected cards from the conservative decks compared with non-apathetic , depressed older adults.
However , ApoE4-driven functional differences within olfactory processing regions have yet to be examined.
However , APOE-ε4 was associated with higher fertility in women exposed to high pathogen levels.
However , Appalachia did not converge toward the US average , and the Mississippi Delta worsened relative to the United States.
However , application of ASL in older populations is hampered by partial volume effects ( PVE ) and tissue dependent changes in CBF.
However , appreciation is growing for the importance of H2S produced endogenously by the evolutionary conserved transsulfuration pathway ( TSP ) in health and longevity.
However , a question remains as to whether Aβ is generated locally from amyloid precursor protein ( APP ) within mitochondria.
However , a regression analysis showed that age accounted for an insignificant amount of variation in our signals.
However , a review of the data shows convincing anti-fracture efficacy already by @number@ months.
However , ARF6 PodKO mice exhibited distinct phenotypes in two in vivo glomerular injury models.
However , a ROS scavenger , N-acetyl-L-cysteine , notably attenuated sulforaphane-mediated apoptosis as well as mitotic arrest.
However arrays optimised for adult brain measurements are suboptimal for research with the significantly smaller heads of young children.
However , ART is unable to completely restore normal health , given the persistence of chronic immune activation.
However , ascribing the motion to the patient rather than caregivers or visitors would require supplemental sensors.
However , as DD levels increase physiologically with age , this testing has less specificity in older patients.
However , as DNA synthesis begins , the SCF complexes are degraded and APC / C complexes are activated.
However , a series of investigations on ancient mummies by autopsy and CT scan concluded that atherosclerosis was commonly seen in ancient times.
However , a serious impediment of chronic NSAID therapy , particularly in the elderly , is gastric , renal and cardiac toxicity.
However , as global populace ages , there is a trend to MBC increasing.
However , Asian aging populations are often underrepresented in studies of patient trust in physicians.
However , Asia-Pacific countries generally lack data on HZ vaccine safety , efficacy and cost-effectiveness.
However , a significant association was observed only for studies with retrospective diet data , not for studies with diet prospectively assessed before cancer diagnosis.
However , a significant decrease in blastocyst embryo formation was associated with increased paternal age , probably reflecting male genomic activation within the embryo.
However , a significant positive correlation was observed between expression levels of SOCS genes.
However , a significant proportion of men with androgen deficiency will be identified when they present for unrelated concerns.
However , a significant reduction of As was observed for immersion combined with human footfall ( wiping by shoes ) .
However , a significant within-individual correlation between the urinary biomarkers was observed ( Spearman r = @number@ p < @number@ n = @number@ ) .
However , a simple model of bigger structure → greater brain response → better cognitive performance might not be accurate.
However , a small change in DS was observed in participants who completed all rounds ( slope = @number@ p = @number@ ) .
However , assessing disease status in these animals has required time-consuming behavioral assessments or postmortem neuropathological analysis.
However , associations among various aspects of brain aging are unclear.
However , associations between SNPs in the gene and other ageing phenotypes such as cognitive and physical capability have not been reported.
However , as SOD1 mutations account for only around 2-5% of ALS cases , additional therapeutic strategies are needed.
However , as the lifespan extends , unseen problems due to the body deterioration emerge.
However , asthenia and bleeding were more frequent in the elderly.
However , as these serum measures are related , it is unclear whether their associations with skin aging occur independently from each other.
However , as the understanding of mitochondria in disease is ever expanding , so is their additional function for a healthy organism.
However , a subgroup of patients with IBS showed a sustained therapy response and benefits from a mesalazine therapy.
However , a subset of lipids is synthesized within mitochondria , and this aspect has become a focus of recent lipid research.
However , a subset of patients with BPD continue to meet criteria for the disorder in older adulthood.
However , a substantial proportion reported age-related concerns.
However , as with prior analyses , this was only observed in those not carrying an APOE e4 allele.
However , as women age , they are disproportionately affected by stroke , coincident with the loss of estrogen with menopause.
However at 9months the connectivity strength decreases within local networks and increases between more distant networks.
However , at a high dose , curcumin suppressed development of steatohepatosis , reduced fibrotic tissue , and preserved glycogen levels in liver.
However , at first , infants rarely communicate successfully with their gestures , prompting caregivers to interpret them.
However , at follow-up 1-month after training ended , only the participants in the active tDCS groups maintained significant improvement.
However , at higher levels of reasonable alcohol consumption , there may be factors leading to reduced brain volume.
However , at higher nucleotide concentrations , only ATP was able to elicit the helicase activity of hSuv3.
However at present cognitive trainings seem to be the most effective in the prevention of dementias.
However , at present it seems that the data obtained in such models cannot be automatically applied to the situation in the whole organism.
However , atrial fibrillation increases in prevalence and atrial arrhythmias progressively become permanent as the population ages.
However , attempts to fully reprogram differentiated cells in adult animals have failed in part because reprogramming leads to the formation of teratomas.
However , attempts to mimic the effects of CR pharmacologically have been limited by our poor understanding of the mechanisms involved.
However , a t test revealed that choice-reaction times were not significantly associated with inattentional blindness.
However , at the same time , compared age groups had significant differences in the number of oocytes and embryos obtained.
However , A-type lamins are also found in the nuclear interior.
However , a unifying molecular mechanism linking these phenomena remains unknown.
However , auto-HCT remains a feasible , safe , and effective therapy for selected older adults with multiple myeloma and lymphoma.
However , autologous stem cells are limited in both quantity and quality in aging individuals.
However , available formulas result in faint staining , discouraging their routine use in donors with assumed difficult preparation.
However , a validated link between the behaviors of such biomarkers and DR effects is lacking at present time.
However , averting human-induced species extinctions within AZE sites requires enhanced planning tools to increase the chances of success [ @number@ ] .
However , a very recent study has shown a significant reduction of pneumonias and death due to pneumococcal disease in nursing-home residents.
However , Avns had no effect on COX-2 expression and PGE ( @number@ ) production in Caco-2 and HT29 colon cancer cells.
However , a weakness of many previous empirical studies is that they use cross-sectional evidence to make inferences on a development over time.
However , a well-functioning repair systems ( i.a. homologous recombination ) remove the damage and prevent harmful changes in the cells.
However , Aβ peptides ' functions are not fully understood and seem to be highly pleiotropic.
However , AβPP can also be cleaved by a non-amyloidogenic pathway , involving an α-secretase , and in this case the Aβ formation is precluded.
However , balance and neurological parameters did not significantly differ between the groups.
However , based on all available data , compounds from these classes appear to act on MTs in a potentially unique manner.
However , based on available evidence , no ocular biomarkers for neurodegeneration which could be integrated in routine clinical diagnostics have been identified.
However , based on its varying molecular size , skin penetration of HA may be limited.
However , baseline contrast energy thresholds in the noncrowded condition were four times that of the controls.
However , BD patients did not differ from controls in the mean trajectory of cognitive changes during the @number@ years follow-up.
However , because ALP includes various isoenzymes from other tissues , an accurate diagnosis is usually not possible on the basis of elevated ALP alone.
However , because cancer cells have incredible heterogeneity and adaptability , it is difficult to target them therapeutically.
However , because it is the outermost layer of the retina , this extracellular matrix is difficult to analyze in vivo with current technology.
However , because of dearth of biomarkers , it is difficult to quantify the neonatal biological age.
However , because of its low bioavailability , the use of curcumin in in vivo trials has been limited.
However , because of the extreme rarity of A673T in non-Nordic populations , the association with Alzheimer's disease has not yet been formally replicated.
However , because of the lack of proper senescence models , exploration of the underlying molecular mechanisms has been hindered.
However , because of the lack of research about the underlying molecular and signaling mechanisms , its efficiency had not been accepted universally.
However , before being recognized as a co-carrier of MCTs , BASIGIN was described as an inducer of extracellular matrix metalloproteases ( MMPs ) .
However , before it can be used national-widely , further research should be conducted in other areas of China.
However , behavioral adjustments are available for species to lower the autonomic work , and thus reduce the energy costs of thermoregulatory responses.
However , behavioral studies suggest the existence of a critical time period for callosal functional development starting around the age of @number@ years.
However , being Black did remain statistically significant and positively associated with life-threatening conditions , even after controlling for SES.
However , being enucleated , they are often referred to as a sac of molecules and their cellularity is challenged.
However , being younger and menopausal increases the risk of progression.
However , benign skin lesions have not yet been investigated.
However , benzodiazepines were commonly used and actions to improve medication safety should target reducing their use.
However , better documentation of the indications for transfusion is needed to confirm these observations.
However , between-visit genetic correlations are significantly lower than @number@ indicating emergence of new genetic effects on CRP levels with age.
However , BFR exercise can overcome this impairment.
However , bilingualism was not independently associated with rates of cognitive decline or dementia conversion.
However , biochemical and survival responses were heterogeneous across CLL and showed only incomplete overlap across inhibitors.
However , biochemical validation of the consecutive alterations of the resulting protein is especially important in these cases.
However , biological mechanisms potentially linking antidepressant exposure to dementia have been described , so an etiological effect of antidepressants is possible.
However , blockage of caspase activation inhibited apoptosis and abrogated growth inhibition in sulforaphane-treated @number@ cells.
However , blood is a heterogeneous collection of different cell types , each with a very different DNA methylation profile.
However , body composition may not be predictive of the progression of knee OA.
However , bone fabric cannot be reliably assessed in clinical QCT images of proximal femur.
However , bootstrap-derived metrics are not independent of the underlying diffusion profile.
However , both age and vascular anatomy can affect flow rates independent of disease.
However , both AMH and AFC can be assessed independently of the menstrual cycle.
However , both between and within samples from industrialized societies , later age at menarche is associated with taller adult stature.
However , both cultures showed increased production of NO and CCL5 in the presence of TNF-a.
However , both diseases are rarely managed together.
However , both groups made significant ( p < @number@ ) and similar gains ( p > @number@ ) in total function scores.
However , both groups were able to adjust and improve task accuracy and efficiency from formulation to task execution.
However , both have their limitations.
However , both HCT modalities have been associated with organ toxicities and graft-versus-host disease , resulting in substantial non-relapse mortality.
However , both in clinical trials and in daily clinical practice , elderly multiple myeloma patients have shown lesser benefit.
However , both local clustering and path length were lower in ε4 + compared to ε4-.
However , both LONG and SHORT translations elicited a similar change in EMG latencies and amplitudes between the older and young adults.
However , both PiB groups performed significantly worse than did the young on cognitive testing.
However , both sexes show marked interindividual variability across age groups with significant overlap seen.
However , both the EXIT and the Quick EXIT also reflect non-ECF domains.
However , both the key factors and biological networks underlying this reprogramming remain elusive.
However , both types of EPHA2 coding variants were present at comparable levels in individuals with or without age-related cataract making simple genotype-phenotype correlations inconclusive.
However , boundaries between the two disorders are blurred by the introduction of broader conceptualisations of BD.
However , boys exhibited larger changes during adolescence than girls for all absolute power measures except alpha.
However , BP ( ND ) in HC was positively linked to executive performance as well as to speed and knowledge.
However , brain banks have evolved to accommodate the banking of biofluids as well as DNA and RNA samples.
However , brain exposure to high cortisol concentrations may also accelerate disease progression and cognitive decline.
However , brain tumor heterogeneity is remarkable and histopathology procedures for glioma classification remain unsatisfactory for predicting disease course as well as response to treatment.
However , by @number@ months of age , as language-specific phonemic maps are established , infants respond preferentially to their native language.
However , by the same assumption , the model fit indexes were worse in the dataset that was missing @percent@ of data or less.
However , caffeine at high doses can increase anxiety , insomnia , calcium loss and possibly the risk of fractures.
However , C-allele and C-genotype ( TC and CC ) were significantly more frequent in the females of non-LG than were LG after sex stratification.
However , caloric intake was associated with ferritin , an iron storage protein ( p = 0.01 ) .
However , CANTAB tests did not consistently load onto the cognitive domain factors derived from traditional measures of the same function.
However , cardiometabolic factors are related to both conditions and may confound and / or mediate the vitamin D-frailty association.
However , cardiovascular disease is more prevalence in men than women.
However , caregivers ' complaints of poor physical health might be construed as somatic expressions of strain.
However , caregivers currently recommend such dental plaque control products to patients suffering from xerostomia in order to reduce the risk of caries and periodontitis.
However , caregivers differ in their readiness to use strategies.
However , caregiving is not always associated with health morbidity.
However , carotenoid utilization failed to decrease major cardiovascular and cerebrovascular events in randomized control double blind trials.
However , cataract surgery was not significantly related to mortality.
However , causality cannot be inferred from these findings.
However , causality remains tenuous because of the strong possibility of reverse causation ( healthy individuals selectively participate in social activities ) .
However , Ca ( v ) β oligomerization occurs independently on the association with α ( 1C ) .
However , CDUS is useful in assessing venous reflux , when palpation is unreliable and / or in detecting recurrence / persistence after surgery.
However , cell aging and the individual himself can lead to reduction of cell functions and consequently , the ability of tissue repair.
However cell proliferation was not changed.
However , cell-related causes in human alveolar bone remain unclear.
However , cells overexpressing mutant PMCA4 protein demonstrated significantly higher level of calcium surge when compared with wild-type.
However , cellular characteristics change during in vitro passaging.
However cellular fibroma may show a greater mitotic activity and therefore they should be referred as mitotically active cellular fibromas.
However , central anorexigenic action of leptin is clearly diminished in aging , most likely due to the impaired leptin signal transduction.
However , central SBP did not significantly increase for any age group after exercise.
However , certain athletic activities and training regimens may place the athlete at increased risk for stress fractures in the spine.
However , certain contexts related to aggressiveness towards people ( but not dogs ) shared significant residual relationships unaccounted for by latent levels of aggressiveness.
However , CHA found little or no mention of the needs of the elderly and their family caregivers.
However , challenges that are sustained over several generations can induce progressive compensatory metabolic adjustments in young adults.
However , change from an individual reference range may indicate important warning signs and thus may require additional evaluation to understand potential underlying pathological processes.
However , change in diet quality was not associated with weight-related outcomes in daughters.
However , changes in immune function associated with stress-related telomere shortening are not well understood.
However , changes in sleep patterns can ultimately affect the quality of life of many older adults.
However , changes in the processing of sounds may be an early , and possibly preclinical , feature of AD and other neurodegenerative diseases.
However , check-ups cannot be omitted as the 5-yearly population study for cervical cancer is not suitable for detecting clear cell adenocarcinoma.
However , ChEIs have also been associated with reductions in behavioural symptoms in Alzheimer's disease patients.
However , children exhibiting a decrease in isthmus thickness revealed an increase in information transfer.
However , children with diabetes had slower total gray and white matter growth than control subjects.
However , children younger than @number@ years old were unable to learn the new spatial coordination.
However , chronic conditions were more strongly associated with poor health status than cancer.
However , chronic metabolic and stress-related disorders involving inflammatory responses can provoke FGF21 resistance and thus disturb healthy aging process.
However , chronic use of lithium is often limited by the development of nephrogenic diabetes insipidus ( NDI ) , a debilitating condition.
However , CIMT-CB could predict stable CAD only in patients over @number@ years of age.
However , circadian rhythms wane with age.
However , claims included in our model regarding dyskinesia and improved medication adherence should be further supported by data from daily practice.
However , clear differences in induction of cytokine production by T cells were seen.
However , clinical and biochemical data regarding growth , puberty , and metabolic outcome , as well as features of female carriers , are scarce.
However , clinical data have been equivocal as to the benefits to the brain and cognition of estrogen therapy in postmenopausal women.
However , clinical data on the safety and efficacy of any of these treatments is lacking.
However , clinical situations are emulated by a GC intervention initiated in the midst of rampant inflammatory responses.
However , clinical studies and insights from model organisms have identified major roadblocks that normal aging processes impose on tissue regeneration.
However , clinical studies have found that these drugs fail to prevent the disease progression.
However clinical trials showed ineffectiveness of the standard therapy regimen.
However , clinicians are hesitant to use lithium in older adults for fear of its medical effects , particularly kidney disease.
However , C ( max ) and T ( max ) were not statistically different between the groups.
However , CMs reported that only about 10%-20% of potentially eligible older adults gave oral consent for PST.
However , cocooning remained incomplete in @percent@ of families and in most families < 50% of close contacts received pertussis vaccination.
However , co-expression of UNC-45 dramatically suppressed PolyQ-72 induced aggregation and partially suppressed myofibrillar disorganization.
However , cognitive control also affects the events after a conflict.
However , cognitive functioning , in particular new learning , was significantly related to SVT performance.
However , collagent expression was not affected.
However , combat-exposed men reported economic advantages , including higher personal earnings at follow-up.
However , combined loss of RB and activation of c-MYC led to an increase in polyploidy in mature hepatocytes before the development of tumors.
However , combining distinct trials and a descending format proved no more beneficial than administering the descending format alone.
However , combining the two measurements does not improve their individual prognostic abilities.
However , communities overlap and share many edges and nodes.
However , community-dwelling older adults within this cluster reported similar levels of depressive symptoms as the High Presence Low Search group.
However , comorbidity and family studies appear to show that the two disorders occur together and aggregate in families at higher than expected rates.
However , comparable data from early developmental stages is crucially lacking.
However , comparison of pretreatment and posttreatment maximum phonation times , acoustic measures , and laryngeal images did not reveal significant changes.
However , compensation fails when it comes to maintaining long-term stability of myelin.
However , compliance had no effect on balancing abilities.
However , comprehensive analysis of specific steps in BER levels in mitochondrial extracts of AD patient brains is not available.
However , comprehensive immunogenicity and safety information for Asian populations is lacking.
However , COMT may further influence posterior cortical regions implicated in language perception.
However , concerns about possible adverse effects , including neurocognitive disorders , were issued by the Food and Drug Administration ( FDA ) .
However , concerns arise about the possible role of these molecules in tumorigenesis and tumor growth promotion.
However , conditioning , shipping and long lasting storage of nucleic acid controls remain problematic.
However , conducting longitudinal studies is recognized as challenging , especially among older adults.
However , confirmation of complete cancer removal following ablation is difficult.
However , conflicting data has been recently published that casts doubt on these assertions.
However , considerable differences exist between these published data sets , both qualitatively and quantitatively.
However , considerable heterogeneity remains in residual decline ( i.e. , person-specific trajectories of cognitive decline adjusted for these common neuropathologic conditions ) .
However , considerable variations in median levels of TT and CFT were observed during the study.
However , considering that aging-induced thymic involution is multifactorial , the thymic reestablishment achieved with treatments that target isolated pathways is incomplete and transitory.
However , considering their nutrition and health status elderly people are a very heterogeneous group.
However , constipation is not a physiological consequence of normal ageing.
However , constitutive NF-kappaB activity is an equally important aspect of NF-kappaB function that is particularly relevant to chronic inflammation and cancer.
However , contradictory opinions exist about whether the lens thickness continues to increase after @number@ years of age.
However , contradictory results are reported about the existence of a cross-modal priming effect in normal aging.
However , contrasting results have been reported in different populations on the value of LTL heritability and on how biology of telomeres influences longevity.
However , conventional axillary surgery has little effect on long-term QOL in older women.
However , conversations were associated with greater trust in one's physician and higher rates of completion of FACP.
However , coronary atherosclerosis and osteoporosis may be aggravated in the presence of hyperthyroidism or hypothyroidism.
However , correlation between mutation-associated reductions in sialic acid production and disease severity is imperfect.
However , correlation is not causation and , sadly , many intervention trials of supposed antioxidants have failed to extend healthspan and to prevent diseases.
However , correlations between telomere length in peripheral blood leukocytes and patients ' physical ability are not known.
However , cross-sectional data cannot distinguish causal direction or whether cortisol and sleep disruption have a common cause.
However , CRP + presented a reduction of physical fitness , increased abdominal fat mass and post-prandial insulin resistance.
However , crucial aspects including the association between OCT- and MRI-based atrophy measures or the impact of MS-related parameters on OCT parameters are still unclear.
However , CSF t-tau was significantly increased ( p < @number@ ) .
However , Cu did not affect reproduction of fish during this period.
However , culture and public policy impact care options.
However , cumulative and over time effects of these medical illnesses have not been systematically examined.
However , current antiplatelet treatments appear less effective in T2DM patients vs nondiabetics at similar risk.
However , current consensus guideline-recommended pharmacotherapy may not represent an optimal treatment strategy in all heart failure patients.
However , current evidence suggests that for most adults , cancer does not have to be an inevitable consequence of growing older.
However , currently available aortic valve devices are inapt for the mitral position.
However , currently available data on the potential benefits of regular physical exercises for HIV-infected individuals are limited.
However , currently the majority of studies are cross-sectional and thus not appropriate for evaluating causality.
However , current precision genomic imaging methods are hampered by the lack of fluorescent probes with high specificity and signal-to-noise contrast.
However , current protocols for identifying senescent cells in vitro and in vivo have several drawbacks.
However , current results are conflicting in Asian population.
However , current status and clinical significance of frailty have not been evaluated for the Korean elderly population.
However , current studies show that late-onset schizophrenia is basically comparable to its early-onset counterpart.
However , current trivalent influenza vaccines ( TIVs ) contain only one of the two influenza B lineages that circulate each year.
However , cytotoxicity and the anti-proliferative effect of Allium atroviolaceum remain unclear.
However , data are lacking regarding the effectiveness of increasing Pennsylvania's cigarette tax to reduce smoking and / or adverse health effects of smoking.
However , data collected so far are inconsistent and does not support this assumption.
However , data concerning this issue have never been examined with a focus on the older population.
However , data demonstrating the independent association between the VACS Index and baseline frailty status is lacking.
However , data derived from clinical trials have reached conflicting conclusions.
However , data from our population show that a significant proportion of the population reaches in the wild @number@ and @number@ years of age.
However , data from population-based studies in Asia are lacking.
However , data from population studies do not indicate that the distribution of TSH is altered owing to inclusion of such individuals.
However , data from primary human immune cells and in vivo studies are limited.
However , data from randomized controlled trials do not show a consistent effect.
However , data on factors that may influence training gains including sociodemographic variables such as sex or age is rare.
However , data on muscle components in relation to subjective and objective indicators of disability is limited.
However , data on reference ranges for ROTEM parameters in children are scarce.
However , data presented herein is not sufficient to support the role of any of these variants in PD pathology.
However , data regarding the nature and determinants of predominant trajectories of memory changes in preclinical AD are lacking.
However , data suggest that , conversely , PF may be a determinant of weight change.
However , data validating Cdc42 activity and expression as biomarker for aging in humans are still missing.
However , data with longer follow-up in this age group are scarce.
However , @date@ ( @percent@ ) incident amyloid-positive subjects had evidence of neurodegeneration prior to incident amyloid positivity.
However , DDAVP administration could be discontinued as GD was gradually improved.
However , debate exists as to the role age plays relative to co-morbidity in terms of health services utilization.
However , deciding the timing of the next visit for these patients and their families is not straightforward.
However , decreased muscle strength and oxidative capacity are related to WE.
However , decreased self-perceived economic satisfaction was not significantly associated with increased hazard of mortality.
However , decreased SOD activity was found in neuroleptic naïve , first episode schizophrenic patients , in chronic-medicated patients and in chronic-unmedicated patients.
However , deeper studies are needed from a suitable animal model.
However , deficits in mitochondrial function have yet to be clearly assessed in tissues outside the central nervous system ( CNS ) .
However , definitive biomarkers for this devastating disease in living people are still lacking.
However , definitive disease-modifying therapy is still lacking.
However , degenerated string capillaries were elevated in AD , potentially suggesting greater microvascular \ "dysfunction \ " compared to ND groups.
However , deletion of Trp53 alone increased the number of fiber cells that failed to withdraw from the cell cycle.
However , deliberative capacities were not associated with performance on the IGT for either older or younger adults.
However , deliberative limitation of activity has the potential to compromise autonomy by increasing social isolation and de-conditioning.
However , demand for institutional care is increasing.
However , depending on the domain , genetic and environmental contributions to the variance differed.
However , deposition studies have typically focused on adult subjects , results of which may not be readily extrapolated to children.
However , deposits of human-sequence Aβ in amyloid precursor protein transgenic mice and non-human primates bind very little PIB.
However , depression in older people remains under-recognized.
However , depressive feelings remained quite stable.
However , despite a number of functional imaging studies on creativity , how creativity relates to brain activity during WM has never been investigated.
However , despite a successful endovascular procedure , some patients do not experience symptomatic improvement and satisfaction with their care.
However , despite being central to contemporary nursing practice , this review suggests that the reality is not matched by the rhetoric.
However , despite decreased basal autophagic activity in senescent cells , autophagy inducers could induce autophagy in senescent cells.
However , despite intense research , so far there is no reliable aging marker.
However , despite its potential utility , concerns still remain for using FRAX in DM patients.
However , despite recent improvements in the application of these markers , they remain under-utilized in clinical practice.
However , despite the close links between hepatic pathology and impaired bone health , the association of liver enzymes with osteoporosis has hardly been investigated.
However , despite the elevated Δψm , the Mpv17-deficient mitochondria showed signs of accelerated fission.
However , despite their importance , factors affecting the transcription of expanded-repeat RNA are not well known.
However , despite the many results obtained , there are still gaps in practically applying a personalized diet design to specific genotypes.
However , despite these ongoing developments , the aetiopathogenesis of IBM remains uncertain.
However , despite the vast amount of literature , brain structural development associated with the amount of parent-child interaction has never been investigated.
However , despite this across-ages accord , we obtained age-related differences on three affective dimensions for a great number of words.
However , DET-L resulted in higher values of blood pressure and BL at workloads beyond AT.
However , detrimental effects of aging on muscle energy metabolism are not universally accepted , particularly when physical inactivity is accounted for.
However , DEVD-TPE exhibited significant fluorescence when it was cleaved by caspase-3 , as well as when the reporter group TPE underwent aggregation.
However , development of FPR1 antagonists for clinical use is still inadequate.
However , development of liraglutide-dependent cholelithiasis has not been reported in the literature.
However , DFA α ( @number@ ) and α ( @number@ ) increased with progressing age similar to measures reflecting linear properties.
However , diagnosis and management of pneumonia in long-term care residents is challenging.
However , dietary intake and weight loss are often overlooked as potential factors.
However , differences between crowns with d = @number@ mm and d = @number@ mm wall thickness were not significant.
However , differences between the species often result in mice being unreliable as preclinical models for human disease.
However , differences in disease presentation and outcomes between older and younger IMN patients remain controversial.
However , differences in experimental protocols used may produce variation that outweighs biological differences.
However , differences in gait may not be salient enough in the early stages of dementia to be detected by actigraphy.
However , differences in tolerability profile are most recognizable in the elderly.
However , differences persisted in patients ≤80 years of age ( OR @number@ @percent@ CI @number@.36-0.94 ) .
However , differences with trainees elsewhere in the world emerge when evaluating additional factors influencing trainees pursuing careers in the clinical neurosciences.
However , different findings were obtained after the scores were standardized.
However , different from the single-gene disorders , high heterogeneity of many of the complex diseases prevents scientists from the exact understanding of the etiology.
However , direct evidence for age differences in brain functional activation and connectivity during emotional processing and concomitant behavioral implications is lacking.
However , directly assessing interactions between these brain regions and networks has proved to be more challenging.
However , direct measurements of muscle forces in vivo are not feasible.
However , direct measures of spontaneous neuronal activity and functional integrity of these impacted neural networks in primary progressive aphasia are lacking.
However , discontinuation of drugs is not standard practice , and prescriptions are usually not adapted to changes in the course of advanced diseases.
However , discovery of methods to more precisely repair the epigenome is the most likely avenue to the development of powerful new antiaging agents.
However , disparities in ambulatory care service intensity and hospital use were observed.
However , disparities still exist , particularly in the context of mechanistic studies investigating estrogen receptor signalling and its potential cellular effects.
However , DKO cells were not protected against death , but high rates of cell death occurred by detachment.
However , DNA co-methylation cluster has not been examined in depth , and co-methylation in multiple cancer types has never been studied previously.
However , DNA methylation patterns are susceptible to change in response to environmental factors and aging.
However , docosahexaenoic acid ( DHA , 22 : 6n-3 ) was reduced in ethanolamine glycerophospholipid and choline glycerophospholipid , but increased in phosphatidylinositol.
However , dose-related safety and efficacy of intramuscular injections of a widely used , locally produced BTX-A in China has not been established.
However , downstream signaling pathways linking TNFα-related inflammation to senescence are not fully characterized.
However , dPGAM5 inactivation fails to modulate the phenotypes of parkin mutant flies.
However , DT training should include task-managing strategies like task switching or task prioritization to be beneficial to improve gait performance under DT conditions.
However , due to changes in facial skin , musculature , fat and bone , anti-aging treatment requires a multifaceted approach.
However , due to concomitant changes in the prefrontal system with age , there are limits to compensation in the aging brain.
However , due to its downregulated expression with aging , RGN is also known as senescence marker protein-30.
However , due to its paper-and-pencil nature it is difficult to adapt for functional brain imaging.
However , due to neutral pH foaming , this method was not suitable for determinations in plasma or red blood cells with high protein content.
However , due to population aging , human diseases with impaired bone regeneration are on the rise.
However , due to respective technical idiosyncrasies they might produce dissimilar modular decompositions of a given network.
However , due to safety and standardization issues , this approach never entered extensive clinical trials.
However , due to the concerns of adverse reactions , drug interactions , and addiction , clinicians frequently hesitate to prescribe opioids.
However , due to the conflicting results , the genetics of VaD is still behind the shadow.
However , due to the cross-sectional design , it is not possible to disentangle the directionality of the relationships observed.
However , due to their limited statistical sizes , some discrepancies were discovered in these studies.
However , due to the nature of the task , our results do not allow a direct transfer to situations involving whole body balance.
However , due to the observational nature of the study , it was impossible to infer causality among the variables surveyed.
However , due to variability of baseline T2 values in volunteers , reference values need to be defined.
However , during aging , little is known about the role of macrophages in the differentiation and function of MSC and HSC.
However , during aging the mechanisms that protect normal cell function begin to fail.
However , during storage , modifications or degradation of those components may occur , and are known as storage lesions.
However , during the last years a few postmortem verified Mendelian pedigrees have been reported consistent with monogenic disease in rare cases of MSA.
However , during the later elaboration phase , the same posterior regions were associated with age-related increases in activation.
However , dyskinesia control still represents a major challenge.
However , each 5-dB decrement in the better-eye MD was associated with @percent@ less time away ( @percent@ CI , @number@ to @percent@ ) .
However , each faces issues with approval for off-label , prophylactic use due to adverse effects.
However , each has toxicities that can negatively impact patients , particularly the elderly.
However , earlier studies have been conducted in small sample sizes.
However , earlier work on brainstem development was limited by sparse sampling across the lifespan and / or averaging across children and adults.
However , early and delayed complications , ranging from minor to severe , can occur following HA-filler injection.
However , early detection of atherosclerosis remains a challenging area of research and development.
However , early physical exercise and PT-based interventions had a positive effect on long-term PF.
However , eastern European survival was lower than that for other regions.
However , effective communication is a key criterion for successful outcomes.
However , effectiveness was shown on three of the secondary outcome measures , i.e. work attitude , self-efficacy and skill discretion.
However , effects did not vary either across different operationalizations of subjective aging or by study quality.
However , effect sizes-when statistically significant-were small in magnitude.
However , effects of lncRNAs on photo-aging remain to be elucidated.
However efficacy is not absolutely compulsory in Medicine.
However , efficacy of these various measures to reduce hip fractures is at most @percent@ and may need months or years before becoming effective.
However , efforts are hindered by the lack of comprehensive understanding of the human immune system function.
However , efforts to date have met with limited success.
However , EGDT and BGDT were not significantly different in either group.
However , eIF2αP-deficient human tumor cells are highly susceptible to extrinsic ROS generated by the pro-oxidant drug doxorubicin by undergoing premature senescence.
However , either a little dose of them or an excess can be harmful for health maintenance at any age.
However , elderly individuals do show a reduced enzyme induction capability and are less able to tolerate overdoses.
However , elderly individuals had significantly lower IgG levels to PcsB and PsaA compared to those of younger donors.
However , embryo quality and pregnancy rate was not significantly different between early and late cleavage embryos in the GnRH antagonist group.
However , emerging data indicates that high velocity PRT ( fast concentric muscle contractions ) is more effective for improving functional outcomes than traditional PRT.
However , emerging data suggest that physical activity may reduce the risk of cognitive impairment , mainly VaD , in older people living independently.
However , emotion regulation , but not cognitive control , was found to mediate the relationship between mindfulness and perceived stress in both groups.
However , emotion work in response to physical health problems is a largely unexplored , yet likely important , aspect of the marital experience.
However , entheseal changes are highly correlated with increased age and the age distributions of the samples analysed could not be compared.
However , environmental and lifestyle-related factors , such as cigarette smoking , may contribute to brain structure changes.
However , enzymatically active AGK is required to maintain mitochondrial cristae morphogenesis and the apoptotic resistance of cells.
However , EPA has not yet provided specific guidance on how to use these age-dependent factors.
However , epigenetic dysregulation is frequently seen with ageing.
However , epigenetic mechanisms involved in defining such cellular traits are largely unknown.
However , epilepsy in the elderly may be underdiagnosed and undertreated because of diagnostic difficulties.
However , equations for estimating appendicular skeletal muscle mass are population-specific , and few have been developed for older Japanese adults.
However , estimates of the prevalence of multimorbidity ( prevMM ) vary widely across studies , impeding valid comparisons and interpretation of differences.
However , estrogen-derived benefit may be attenuated in aged , reproductively senescent ( RS ) rats.
However , ethnic differences in age-related facial skeletal changes have not yet been fully established.
However , even acute bouts of activity can restore the sensitivity of older muscle to dietary protein.
However , even among existing frailty definitions , components require rigorous and consistent standardization.
However , even at lower viral loads , chronic HIV infection appears to have consequences on aging processes , including the development of frailty.
However , even the oldest children were unable to sustain fear-prioritization when the onset of the target was delayed.
However , even though AAL technologies are on the rise , the acceptance of them among the elderly population is still low.
However , even using practical , clinically relevant variables , it is not possible to accurately predict exercise capacity from a regression equation.
However , even when controlling for overall brain size , male patients showed smaller HV compared to female patients.
However , evidence based on prospective study is very limited.
However , evidence is currently lacking regarding how to achieve this in this patient population.
However , evidence is inconclusive regarding the influence of this polymorphism on older adults ' functional responses to exercise.
However , evidence is lacking regarding the role of intermittent fasting.
However , evidence on the association between SUA and arterial stiffness is limited to contradicting cross-sectional studies.
However , evidence that MetS itself is related to cognitive performance has been inconsistent.
However , evidence to support the use of such home-based rehabilitation is limited.
However , exacerbated activation may occur in the course of several diseases , resulting in metabolic disorders and atrophy.
However , exactly how simultaneous tasks affect the kinematics of walking remains unclear.
However , exact mechanisms to explain the associations remain unclear.
However , examination of individual trajectories suggested substantial heterogeneity.
However , examining the functional consequences of those variants has created an analytic bottleneck.
However , except insulin and insulin-like growth factor receptors , the functions of membrane receptors in animal lifespan modulation have not been well appreciated.
However , excessive bone resorption has also been found to occur in the early stages of OA.
However , exercise-induced improvements in the HR recovery response to exercise may be impaired in late middle-aged and older women.
However , existing LGN segmentation methods are non-automatic , inefficient and prone to experimenters ' bias.
However , existing prospective evidence is limited and controversial.
However , exocrine cells retain CENP-A expression.
However , experience can have both behaviorally beneficial and detrimental effects.
However expert consensus is that molecular alterations in different cells are involved in the development and progression of the disease.
However , expertise seems to counteract some of the age effects.
However , exploiting such a cumbersome tumor microenvironment for cancer treatment could provide tumor-specific therapeutic approaches.
However , exponent @number@ will underpredict drug clearance in children older than @number@ months.
However , exposure to the very intense ambient radiation can pose a hazard particularly if the recipient is over @number@ years of age.
However , expression of this truncated sortilin redistributes BACE1 from the trans-Golgi network to the endosomes and substantially reduces the retrograde trafficking of BACE1.
However , extensive studies examining pathogenic mechanisms are needed ( Tab.
However , external support kept production costs lower than they would have been without PEPFAR.
However , extracellular hemolytic activity depended on the population growth phase.
However , facilitation develops slowly over the first year after birth.
However , factors that influence participant satisfaction have not been well studied in dermatology-specific behavioral health interventions.
However , factors that underlie Aβ deposition are incompletely understood.
However , female inmates use higher volumes of care , and the volume of GP consultations increases with age.
However , female sex and aging with typical prevalence of hypertension and diabetes were accompanied by increased myocardial T2 values.
However , females receiving ceramide had increased plaque burden ( number , area , and size ) compared to controls.
However , few clinical studies have evaluated the efficacy of combination therapy with both testosterone replacement and chronic PDE5Is.
However , few data about peanut allergy in developing countries are available.
However , few data are available on patient-reported outcomes after fractional ablative skin-resurfacing.
However , few data compare the simultaneous effects of elevated serum glucose and aging on AD.
However , few epidemiologic studies have examined mechanisms through which ambient temperature may influence cardiovascular function.
However , fewer studies have comparatively studied the angiogenic efficacy of MSCs derived from different tissues sources.
However , few have examined the contribution of low-frequency coding variants on a genome-wide level.
However , few have had advance care planning discussions or completed documentation to ensure future care preferences are acted upon.
However , few have investigated coagulation and fibrinolysis in FAP.
However , few have studied WM changes over time , and none evaluated individual differences in change across a wide age range.
However , few investigations have examined their relative predictive power , or probed for possible indirect effects and age-moderated effects.
However , few models of three-repeat Tau are available.
However , few older adults engage in routine PA , and even fewer take advantage of programs designed to enhance PA participation.
However , few people are exactly symmetric in terms of morphology or movement patterns and effects of symmetric cueing on gait steadiness are inconclusive.
However , few reports about the relationship of allicin and Sirt1 have been published.
However , few specific recommendations on second-line agents are provided.
However , few studies account for the possible influence of comorbid medications when conducting tDCS research.
However , few studies consider the adoption of mobile health services with regard to older and middle-aged users.
However , few studies examined the anticipation of peer interactions , a key component in the etiology and maintenance of anxiety disorders.
However , few studies exist concerning the essential meaning crucial for the overall understanding of sexuality in later life.
However , few studies focused the relationships among the very old.
However , few studies have assessed the effect of caffeine ingestion on performance , particularly functional performance in older adults.
However , few studies have been conducted in elderly non-institutionalized subjects.
However , few studies have been performed to assess the utility of this scale in an older population with cognitive impairment.
However , few studies have dealt specifically with the assessment of body composition of undernourished older subjects by different methodologies.
However , few studies have empirically examined beneficial effects of allotment gardening.
However , few studies have evaluated the associations between air pollution and glycosylated hemoglobin ( HbA1c ) levels.
However , few studies have examined the benefits of exercise on SRF in adolescents with ID.
However , few studies have examined the relationship between simultaneous turning tasks and the severity of PD.
However , few studies have examined the relative importance of various specific diagnoses in population-based samples.
However , few studies have examined the typical order in which items recover on PTA scales.
However , few studies have explored the effects of aging on diffusion imaging measures with higher b values.
However , few studies have investigated behavioral and neural responses to both gains and losses in pre-pubertal child populations.
However , few studies have investigated how healthy aging influences these cognitive processes.
However , few studies have investigated the epidemiology and progression time from transient to permanent psychiatric disorders for AIPD and SIPD patients.
However , few studies have investigated the relationship between site-specific muscle loss assessed using computed tomography ( CT ) and metabolic syndrome.
However , few studies have investigated the relationship between the Aging Males ' Symptoms ( AMS ) scores and metabolic abnormalities.
However , few studies have reported the development of VR tasks.
However , few studies have specifically examined the efficacy of such procedures among men.
However , few studies to date have investigated the safety and durability of anti-tumor necrosis factor ( TNF ) therapy in this subgroup.
However , few studies use data to support this model , and it has yet to be examined in the U.S. Chinese community.
However , few studies were conducted to examine their functions , especially in composite diet supplements.
However , few such trials have been carried out and their overall quality was poor.
However , few tools have been developed for use with caregivers.
However , few validated surrogate endpoints of chronic disease risk exist.
However , findings from this investigation are compelling for the care of patients of all ages.
However , findings regarding their relationships are inconsistent.
However , fitness-associated advantages in cognitive functioning were already present in childhood.
However , FM distribution has received very little attention.
However , food insecurity and obesity coexist among low-income , older women.
However , for females , no equivalence was found between the real age and the estimated age.
However , forget-cued postmenopausal women showed reduced list @number@ forgetting but enhanced list @number@ retention.
However , for older adults , the visual system displayed reduced activity when the probe appeared over angry facial expressions.
However , for older adults who did not use positive reappraisal , decreases in attention to negative information were associated with less negative emotions.
However , for people aged @number@ and above , they may be more influenced by the environmental factors.
However , for some specific factors and items , caution is required when comparing the depressive symptoms between Chinese and Dutch elderly groups.
However , for the further development of dysphagia diets , new attempts based on new concepts are needed.
However , for the large proportion of risk that remains unexplained , population specificity of pathogenic variants could interfere with the detection of disease-associated loci.
However , for the same parity rates , the estimation of infective life expectation is very different between Ae. aegypti and Anopheles gambiae mosquitoes.
However , for those LAT partners already confronted with illness in their current relationship , all provided care to the partner in need.
However for very rare variants ( MAF ≤ @percent@ ) , only 0-1% of the variants were well imputed.
However , forward serial clustering was not significantly positively correlated with gray matter volumes in any region of lateral prefrontal cortex.
However , for women with incontinence , poor glycemic control ( HbA1c ≥9% ) is associated with more limitations in daily activities due to incontinence.
However , free APC2 is decreased , inhibiting cell proliferation.
However , from early childhood to late adolescence , the location on the scalp showing maximal SWA underwent a shift from posterior to anterior regions.
However , from the second disease onward , each additional co-occurring disease caused cumulative declines in SRH.
However , functional changes associated with telomere shortening are poorly understood.
However , functional connectivity among regions involved in emotion perception has not been studied so far.
However , functional knowledge of PARIS is limited , and no other studies have been performed to elucidate its function.
However , further along the disease progression scale , CVLT delayed recall and visual memory changed more rapidly than CVLT immediate recall.
However , further analyses suggested that the age differences were mainly manifested in sleep-based declarative memory consolidation but not in procedural memory consolidation.
However , further assessment of NPC disease genes in age-related neurodegeneration is warranted.
However , further experiments with specific animal models for brain injuries are needed before clinical trials can be started.
However , further high quality trials are needed to confirm this evidence , especially beyond weight loss.
However , further increases in IIV over and above those found in normal ageing may be a risk factor for future cognitive impairment or mortality.
However , further investigation on the mechanism of TRF in reversing the myoblast aging is needed.
However , further longitudinal studies might be needed to confirm these findings.
However , further more confirmatory researches are needed to elaborate these findings at the translation level.
However , further prospective investigations are warranted.
However , further research and characterization of molecules is necessary to establish a strong connection between T2D and AD.
However , further research is needed to clarify factors that may be directly causal as opposed to confounding relationships.
However , further research is needed to create new , more standardized guidelines.
However , further research is needed to demonstrate the efficacy of these alternative treatment strategies in clinical trials using controlled and prospective studies.
However , further research is required to determine if the proposed patient-centred deprescribing process will result in improved patient outcomes.
However , further research is required to validate our observations , and establish clinical utility.
However , further research is still needed with respect to greater understanding of the pathophysiology underlying the development of VMT and IMH.
However , further research should be done to identify the causal effect of health insurance on health-related behavior.
However , further studies are needed to examine approaches that facilitate maintenance of the improved outcomes by combined exercise training and nutritional intervention.
However , further studies are required to define causality.
However , further studies are required to determine the active component ( s ) responsible for these effects.
However , further studies are warranted to fully understand the relationship between the early environment and long-term effects on metabolism.
However , further study is required to determine whether , and to what extent , a causative relationship exists.
However , further targeted studies are needed to better define the efficacy as well as safety profile in frail and older patients with comorbid diseases.
However , FUs with higher levels of gait impairment improved more in velocity , stride length and toe off angle compared to the FTUs.
However , future studies need to prospectively address what are biomechanical age-related risk factors in runners.
However , future studies using additional cardiac markers should be completed to confirm these findings.
However , future validation with longitudinal data is still needed.
However , future validation with longitudinal data is still needed.
However , future validation with longitudinal data is still needed.
However , G5 Terc- / - mice with short telomeres had increased metastatic tumor burden similar to wild type mice.
However , galectin-3 , but not galectin-1 , was expressed in the DCT.
However , gaps remain in our understanding of several fundamental and applied questions , particularly related to the design of interactive , personalized decision aids.
However , GAS muscle-tendon mechanics and energetics were significantly more sensitive to changes in tendon compliance than were those for SOL.
However , GDF15 was increased also in a wide range of nonmitochondrial conditions.
However , GDM-exposed ECFCs exhibited decreased network-forming ability in Matrigel.
However gender does not play a role.
However , gender was the only determinant of muscle strength in the young.
However , generalizability of results is limited by small sample sizes.
However , genetic damage in XP is the decisive factor and not merely ultraviolet exposure.
However , genetic factors associated with lung function in individuals with exceptional longevity have not been identified.
However , genetic factors cannot be ruled out , since consistent evidence has implicated genetic factors in smoking behaviour.
However , genetic influences on neuroanatomic structure in sporadic FTLD have not been assessed.
However , genetic mechanisms responsible for these associations are not known.
However , genetic screening of prion protein gene becomes relevant in familial degenerative dementia , particularly in geographical areas with high IPD prevalence.
However , genetic studies of rare familial forms have led to the identification of mutations in causative genes such as VHL and FLCN.
However , genetic studies of the role of rare TREM2 variants in FTD have generated conflicting results possibly because of difficulties on diagnostic accuracy.
However , genome instability can be enhanced by exposure to external genotoxic agents or as the result of cellular pathologies.
However , genome-wide information about p53-target gene regulation has been derived mostly from acute genotoxic conditions.
However , genotype-phenotype correlations using the @number@ missense mutations within the LMNA gene are unclear : partially due to the limited availability of three-dimensional structure.
However , ginger extract and its pungent constituents had no effect on TRPM7 currents.
However , given an increased prevalence of IgA deficiency among coeliac patients there is a risk of false negative results.
However , given our limited sample size , generalizability was restricted and studies with larger cohorts are required to further validate our findings.
However , given the huge complexity of this methodology , toolboxes for graph-based network visualization are still lacking.
However , given the inverse association between CRF and obesity , the independent contributions of BMI toward HF risk are not fully understood.
However , given the limitations of both sample size and genome-wide metrics , this hypothesis has not been comprehensively tested in human populations.
However , global regulatory mechanisms of AR signaling mediated by such factors have not been well investigated.
However , glycemia was negatively associated with visuoconstructional abilities and processing speed.
However , good medical assessment and careful patient selection are necessary.
However , GP-LR methods confer a number of benefits over kernel SVMs.
However , GPs indicated that they were substantially more likely to prescribe pharmacological options than other forms of therapy.
However , graduates from nursing programs are failing the NCLEX-RN on the first attempt.
However , greater caution needs to be considered before treating with drugs because of the altered risk-benefit profile in the elderly.
However , group comparisons revealed lower tongue protrusion and lateralization strength in the oldest participants.
However , group differences remained significant after controlling for the influence of other cognitive factors.
However , GSIs , but not GSMs , markedly increase the levels of APP CTFs that are increasingly viewed as disrupting neuronal function.
However , guidelines for non-cognitive psychiatric disorders typically do not mention screening older adults for B12 deficiency.
However , H2S did not change the function of other ion channels , including IK1 and INa.
However , habitual coffee intake has not been linked conclusively to long-term increases in basal BP , and findings are inconsistent by sex.
However , half of the @number@ recessive single gene causes of disease are still unknown.
However , having both alleles with CGG repeats outside the normal range might still adversely affect ovarian aging.
However , having hyperlipidemia increased the probability of catheterization ( RR @number@ @percent@ CI @number@.86-6.98 ) .
However , HBV vaccine responses in HCV-infected individuals are often blunted compared with uninfected populations.
However , HC volumes did not predict context retrieval performance in older adults.
However , HDLs possess several other attributes that contribute to their protective effect against cardiovascular diseases.
However , health effects of long-term exposure to constituents of PM on total CVD mortality have been explored in a single study only.
However , healthy obesity is not explained through differences in leisure-time sedentary behaviour.
However , hepatic glycogen synthesis was markedly increased with a decrease in phosphoenolpyruvate carboxykinase protein expression.
However , hetero-radiosensitivity occurs in different patients.
However , high concentrations of palmitoyl-CoA would induce a decline in flux and an accumulation of intermediate metabolites.
However , higher BMI was related to higher LINE-1 methylation , and height was positively associated with Alu methylation.
However , higher CR scores were associated with faster cognitive decline after symptom onset of MCI.
However , higher estradiol was significantly correlated with better global cognitive function in men , suggesting gender-specific differences.
However , higher IMT values were observed among men and women sequentially exposed to low SEP in more than one period of life.
However , higher levels of IL-6 and CRP predicted depressive symptoms at 5-year follow-up.
However , higher protein intakes in the context of mixed-nutrient ingestion also confer anabolic benefits by reducing protein breakdown.
However , highest hysteresis area was verified when comparing the system in the presence and in the absence of RP.
However , high quality supervisor-subordinate relationships did moderate the effects of age dissimilarity on supervisory ratings.
However , high variability in measurement methods used to assess both SS and PA in included studies made it difficult to compare studies.
However , high-volume training appears to be more efficient for lower-body muscles after @number@ weeks of training.
However , hippocampal levels of androgen and estrogen are much higher than those of plasma.
However , histological investigations of the underlying structural changes , which might predispose to fracture , have been largely limited to the cancellous bone.
However , histological studies of amyloid plaque bearing APP transgenic mice provided only evidence for an activation of the early parts of the complement cascade.
However , HIV remains complex , presenting unique characteristics distinguishing it from other long-term conditions ( LTCs ) .
However , home-modification implementation is not standard practice in the United States.
However , homeostatic forces that dictate such changes remain incompletely understood.
However , homozygous knockin mice did display intriguing age-dependent changes in axonal transport of mitochondria , and increased spontaneous locomotor activity in old age.
However , hormones at age-specific levels may regulate not only age-associated mechanisms but also tumor suppressor pathways that influence carcinogenesis.
However , how ALS pathology spreads progressively during disease evolution is still unknown.
However , how and when the established genetic risk locus BIN1 rs744373 confers risk to late-onset AD has yet to be determined.
However , how human telomere transcription is regulated is still largely unknown.
However , how inflammatory gene signatures and cREL / p63 / p73 targets are comodulated genome wide is unclear.
However , how intracortical myelin content evolves during development , decays in aging , and links with cognition remain poorly understood.
However , how PINK1 and Parkin regulate mitochondrial activity is largely unknown.
However , how progranulin and TMEM106B interact to regulate lysosomal function and frontotemporal lobar degeneration ( FTLD ) disease progression is still unclear.
However , how robust YAP activation is achieved during organ size control remains elusive.
However , how stem cells contribute to homeostasis in the dermis has not been elucidated.
However , how such increases coordinately regulate induction or repression of hypoxia-responsive genes is largely unknown.
However , how the amount and quality of sleep affects Aβ aggregation is not yet well understood.
However , how the cell integrates RNA-processing programs with post-translational protein quality control systems is unknown.
However , how the chromatin is reorganized during SAHF formation is poorly understood.
However , how the extracellular amino acids reach the lysosomal lumen and activate mTORC1 remains unclear.
However , how their experiences can shed light on elderly learning theory has not been examined much in the literature.
However , how these cellular events are orchestrated in the aging progress is not fully understood.
However , how these families make the decision to institutionalize remains unclear.
However , how these mechanisms affect cortical and subcortical activity during semantic and phonological processing has not been extensively explored.
However , how these two major cancer genes functionally interact during tumorigenesis is still unclear.
However , how this dynamics plays a role in the progression of diseases is largely unclear.
However , how TIF1γ regulates the development of different blood cell lineages and whether TIF1γ is involved in human hematological malignancies remain to be determined.
However , how to maintain these capabilities is not fully understood.
However , H. pylori was discovered and the infection was indicated to be the main cause for the atrophic change of gastric mucosa.
However , HS / MTS was associated with increasing age and memory impairment in the AD group but not in the FTLD group.
However , Hsp90 binding to hTERT was not affected by CHIP overexpression.
However , human APP expressing adults developed age-dependent defects in both climbing and flying.
However , human arsenic exposure is typically in the parts per billion ( ppb ) range.
However , human cells have complex systems to avoid the deleterious effects of the reactive species produced by sunlight.
However , human clinical intervention studies are needed to fully substantiate the potential of mitochondria as a target to prevent cardiometabolic disease.
However , human cortex was affected by severe membrane protein oxidation , while exhibiting lower than average cytoplasmic protein oxidation.
However humans live much longer than other apes do.
However , hypertension was not associated with poor physical and functional capacity.
However , hypertrophy is different from thickness.
However , IADLs are often less effective in younger cohorts or in healthy community-dwelling samples , presenting with large ceiling effects.
However , ICS are widely used in up to @percent@ of COPD patients , including those at low risk of exacerbations.
However , identification of disease-causing variants within association loci remains a major challenge.
However , IDF definition presented a stronger correlation with arteriogenic ED.
However , if autophagy is not resolved properly , clearance of toxic proteins or aggregates cannot occur effectively.
However , if calcification is to be targeted , ensure that bone health is not compromised by the treatments.
However , if divergent thinking declines steadily in aging still has to be clarified.
However , if ER stress reaches critically high levels , the UPR activates destructive outputs to trigger programmed cell death.
However IFN-α did not affect the translocation of hTERT from the cytoplasm to the nucleus.
However , if weight gain or onset of obesity occurs after @number@ years of age , an adverse impact on adult lung function is noted.
However , IGF-I has been consistently shown to be a potent neuroprotective factor in mammals , and as such , a deterrent of brain aging.
However , IL- @date@ upregulate CD95 on A-T lymphocytes.
However , illnesses frequently associated with aging in the absence of HIV / AIDS appear to occur prematurely in HIV / AIDS patients.
However , immigration biography played a role when patients ' and their parents ' birthplace were taken into account.
However , immunosuppressive properties of MSCs are reduced.
However , impaired insight was associated with higher levels of apathy.
However , impaired priming in patients with AD does not appear to be due to disruption of this neuromodulatory system.
However , implant affected ( P < @number@ ) overall liking , flavor , juiciness , and tenderness for USDA Select steaks aged @number@ d.
However , implementation created challenges , because the professional identity of the pharmacists reduced their options for serving as peers with the same ethnic background.
However , implementation factors were rarely considered in intervention development , which may contribute to limited uptake and reach in real-world settings.
However , important differences were observed between early-exposed and later-exposed bilinguals in their earliest-exposed language.
However , importantly , NAMPT-induced epithelial-to-mesenchymal transition was found to be independent of NAMPT enzymatic activity and of the NAMPT product nicotinamide mononucleotide.
However , important methodological limitations challenge this suggestion.
However , improvement in cognition over the course of treatment was more prominent in the Young Old group than in the Older group.
However , improvement in depressive symptoms was significantly associated with improvement in global cognitive function in Young Old participants but not in Older participants.
However , improvement in nuclear morphology in tissues after treatment of animals has not been demonstrated.
However , inaccessibility of inner ear tissue in humans severely restricts possibilities for experimental manipulation to develop therapies to ameliorate this loss.
However , in addition , non-Hispanic white populations are simply more widely studied.
However , in AD MAOA-uVNTR S-allele carriers a steeper increase of HAMD and STAI1 sum scores ( P < @number@ ) was observed.
However , in adults ≥55 years , NCDs were the commonest diagnoses.
However , in aMCI , lower anterior DMN-DAN anti-correlation was associated with lower memory performance.
However , in an earlier pilot study , we showed evidence of a positive association between cerebral glutathione and dairy intake.
However , in Asians , there have been several unusual case reports that have shown only subtle melanocytic proliferation despite clinically malignant manifestations.
However , in a subgroup of @number@ individuals aged @number@ and above , the network properties were significantly correlated to WAIS-R.
However , in both groups the peak was not aligned with the optimum of efficiency.
However , in both sexes , children with early rebound have significantly greater increases in FM velocity from @number@ years of age.
However , in case of severe local inflammation , there is a greater risk for massive hemorrhage.
However , in children cortical growth may be impaired with oversized body growth.
However , in cholangiocarcinoma ( CCA ) the correlation between miRNAs and their potential roles in CCA remains unclear.
However , in clinical practice , genetic investigations are not helpful due to the small effect size.
However , in clinical settings , physicians and surgeons who treat such patients have few available options.
However , including families and dementia residents in decision-making can be challenging for care staff working in nursing homes.
However , in comparison with premenopausal women , they showed a lower habitual F0 in continuous speech.
However , in conditions that induce top-down restoration , a robust compensation was observed.
However , incongruent results largely due to high false positive rates indicate the need for standardization of quality criteria and software tools.
However , inconsistent results were also reported in some studies of Non-European descents.
However , in contrast to adults , children do not always show a sleep-related improvement in implicit learning.
However , in contrast , we found that maternal grandparents who experienced conflict in their relationship with their daughter were also at risk for estrangement.
However , in Cox regression analysis adjusted for age , gender , comorbidity and MNA score , dentition status no longer predicted mortality.
However , increased caspase-2 and @number@ expression in certain types of tumor has also been linked to promoting tumorigenesis.
However , increased expression of CD33 mRNA was associated with increasing AD pathology in temporal cortex brain samples.
However , increased ILB height was associated with increased age.
However , increased life expectancy with HIV introduces the added complication of age-related cognitive decline.
However , increased or prolonged exposure to estrogen is the most important risk factor.
However , increases in health care spending are not usually linked to corresponding increases in need for care within populations.
However , increases in healthy life expectancy may not keep pace.
However , increases in MAP were similar between groups , indicating that the pressor response at the onset of handgrip exercise is preserved with aging.
However , increases in overall physical activity levels are mainly due to increases in walking , gardening , and home exercise.
However , increases in staff comfort level providing care to PLHIV were comparable between both groups.
However , increasing age imposes changes in neural progenitor cells and their microenvironment that lead to a reduction of neurogenesis.
However , increasing evidence indicates multiple functions of caspases outside apoptosis.
However , incubation of rHu-sRAGE with purified IgGs from HD patients had no effect on sRAGE quantification.
However , in demented adults with DS , ApoE4 was associated with higher Aβ40 but not Aβ42.
However , independence in social activities was decreased , suggesting the need for comprehensive social support.
However , independent of the definition used , depression prevalence varies greatly by dementia status , physical functioning , and marital status.
However , indicators of functional disability among adults living with HIV is still not well understood and is likely multifactorial in nature.
However , individual differences in phonological capacities explain variability among individual older adults.
However , individual subjects responded differently.
However , individuals who are at an extreme SES disadvantage are the most vulnerable to have relatively low BMD in the study population.
However , individuals who are not currently working can still be highly employable and even sustainably so , but just be between jobs.
However , individuals with low LINE-1 methylation ( < median ) had a @number@.2-fold ( @percent@ CI @number@.4-7.5 ) higher prevalence of lung cancer.
However , individuals with low testosterone and epsilon4-negative status had significantly larger hippocampal volumes relative to all other groups.
However , individuals with PD often have difficulty with exercise.
However , in elderly persons there was a lower percentage of PBMC samples producing more than one cytokine upon antigenic stimulation.
However , in fat-3 mutants lacking delta-6-desaturase , the trans-isomer caused modest decreases in lifespan and progeny after three generations.
However , in forensic practise , teeth are not always available.
However , information about potentials for low-cost and low-risk interventions is limited.
However , information about TCR repertoires to defined viral antigens is limited.
However , information from population-based studies conducted in representative age groups is so far limited.
However , information in patients with symptomatic peripheral arterial disease ( PAD ) is sparse.
However , information on clinical and biomarker correlates of Apo-E proteins is scarce.
However , information on the cellular sites of OS and antioxidant responses in aging human retina remains limited.
However , information on the impacts of caring for relatives with COPD on carers ' psychological health is limited.
However , information on the mechanistic basis for some associations is limited.
However , information regarding the function and structure-activity relationship of apoE in lower vertebrates is rather limited.
However , in Ghana there is paucity of data exploring the epidemiological , etiological and health associations of medical conditions with SD.
However , in hardly any of these studies , depression was systematically and adequately assessed.
However , in HFD this increase was abolished.
However , inhibition of PUMA may be beneficial for curbing excessive apoptosis associated with neurodegenerative disorders.
However , in humans as well in AD mouse models , identification of early biomarkers of network dysfunction is still at its beginning.
However , in humans , turning preference is inconsistent across studies , and its neural correlates are unclear.
However , in individuals without MCI at baseline , there was a trend for a neuroprotective effect of statins on cognitive decline.
However , injury of the aging lung may result in emphysema.
However , in many LMICs , infectious diseases are still prevalent resulting in a \ "double burden \ " of disease.
However , in many states that have compassionate release policies , few patients are actually granted release.
However , in men , there was no significant difference in prevalence of these habits between subjects with and without osteoporotic fracture.
However , in metastasis caused by cancer cell clusters , EMT may not be necessary.
However , in most tissue types the capillary network has an anisotropic micro-architecture.
However , in multivariate analysis , older age was the only significant predictor for higher atazanavir concentrations.
However , in noncanonical UPP , proteins can be degraded by the 26S or the 20S proteasome without being ubiquitinated.
However , in older adults , higher expression of fronto-visual fC was linked with lower levels of clinically silent AD pathology.
However , in order to more comprehensively assess aging sexual stigma , future research may benefit from measuring explicit and implicit aging sexual stigma beliefs.
However , in other conditions abnormalities in the region are clearly linked to disease.
However , in our current clinical practice , these medical conditions are generally evaluated and treated in isolation.
However in our study , FOXO3a activation appeared earlier than that of SIRT1.
However , in participants with a Mediterranean background , low DGI-2013 scores were not generally associated with poorer health.
However , in patients with age-related macular degeneration , this parainflammatory response becomes dysregulated and contributes to macular damage.
However , in patients with significant motor fluctuations , dopaminergic agents may be added with caution , as they are notorious for several adverse reactions.
However , in recent years , it has emerged that T3 and its metabolites can also act through non-genomic mechanisms , including cytosolic signaling.
However , in recent years , there has been an increase in the amount of research on this subject.
However , in several national health systems , primary care is not directly managed by the regions but is in charge of smaller territorial entities.
However , in situations where postural control requires more central processing , cognitive resources may be exceeded by the addition of an attentionally demanding task.
However , in somatic cells lacking the Piwi-piRNA pathway , gradual chromatin decondensation increasingly allows the mobilisation of TEs as the organism ages.
However , in some parts of Africa , it still continues to be a challenge.
However , in some patients , PA exhibits an aggressive clinical course.
However , in some specific conditions ( e.g. during exercise ) , change in CBF does not synchronize with that of cerebral metabolism.
However , in spite of severe cardiac and respiratory events of central origin , autonomic dysfunction potentially induced by this virus is poorly understood.
However , in spite of these advantages , genome-wide association studies ( GWAS ) with longitudinal data have rarely been analyzed taking this into account.
However , instruments measuring the person-environment interaction are lacking.
However , insular sensitivity was greater for disgusted than for angry faces.
However , insulin sensitivity is not generally reduced with age , when groups are carefully matched for physical activity and body fatness.
However , intake above the recommended dietary levels may be detrimental , and uncertainty exists on the potential health benefits of supplementation in this population.
However , intensive cognitive training can improve important cognitive functions , such as attention and working memory.
However , intentional non-adherence is regularly observed and results in negative outcomes for patients along with increased healthcare provision costs.
However , interactions between stimulus spacing and stimulus modality have not been examined systematically.
However , interference with the tumor-suppressor role of wild-type EZH2 must be avoided.
However , in terms of gerontological education , they seem to share great commonalities.
However , interstrand crosslinks ( ICLs ) , which preclude DNA unwinding , are considered absolute blocks to replication.
However , interventions on moral norms related to the use of DA should be treated with caution.
However , in the context of increasingly aging trend in China , the prevalence of etiological agents among elderly diarrheal patients was undetermined.
However , in the course of time , with the increase in their use , more and more side effects have been reported.
However , in the elderly , the etiology of anaemia is often multifactorial.
However , in the following months , a restenosis was observed that required new interventions to reestablish a satisfactory vascular access function.
However , in the later measurements when BMI increased into the obese category , a drop in lung function was observed.
However , in the majority of older adults who have normal kidney function , lithium use appears to be safe.
However , in the medial-temporal structures , volume and iron content exhibited different age trajectories.
However , in the music group , there were no statistically significant improvements of quality of life in each sub-score over the @number@ weeks.
However , in the past decade , we have witnessed a dramatic shift and now these two fields are intertwined.
However , in the remaining ≈29% with poor antibiotic responsiveness , a deterioration of all variables is observed.
However , in the same circumstances , some people see solitude as an experience of maturity.
However , in the six studies ( @percent@ ) reporting significant gender differences in outcome , gender distribution was in accordance with prevalence rates.
However , in the subsequent genotyping , none showed a significant association with LOAD risk after Bonferroni correction.
However , in the triple-task context with its maximum resource demands , older adults prioritized postural control over both force control and memory.
However , in the United Kingdom , the National Health Service has no routine delirium prevention care systems.
However , in the young , no significant association between respective variability and TA activity was found.
However , in the young-old cohort , neither the short-term nor the long-term mortality rate was increased.
However , in this paper , we adjusted the bone Pb values for the uncertainty level.
However , in today's obesogenic environment , this fine-tuned immunometabolic interface is perturbed.
However , intragenerational support from spouse and siblings was not significant.
However , intraindividual variability in response time ( RT ) was strongly related to ERN amplitude.
However , intrinsic evidence for such a link between healthy aging and development in brain structure remains elusive.
However , investigations are lacking regarding the risk factors for CVDs specific to BD patients.
However , in vitro expansion was inescapably accompanied with cell senescence , characterized by inhibited proliferation and compromised pluripotency.
However , in vivo determination and monitoring of neurodegeneration remain difficult.
However , in vivo neuroplasticity in humans has been difficult to demonstrate.
However , in women , it may often be caused by cystitis in clinical settings.
However , in women , only the old-old age group showed significant positive correlations between knee extension strength and leg and appendicular muscle mass.
However , in women , the correlation between muscle strength and muscle mass differed according to age.
However , in women , this correlation was not significant in the lumbar spine ( LS ) .
However , iPSCs derived from CSB patient's fibroblasts exhibited elevated cell death rate and higher reactive oxygen species ( ROS ) production.
However , IPSS , QOL index , and endocrinological and uroflowmetric data showed no significant difference between the groups.
However , iron levels should be maintained within a narrow range.
However , isomerization in structured domains , although less common , often yields more dramatic effects on solubility.
However , it appears difficult to use and time-consuming.
However , it appears that relatively low circulating levels of IGF-1 in humans are associated with aging-related diseases and diminished longevity.
However , it begins to recede in size and function , from early in life.
However , it can be seen that the Chi Linh population is undergoing a strong \ "aging \ " trend.
However , it can induce cardiac side effects such as bradyarrhythmia and should be used with caution in elderly patients or patients with cardiac disease.
However , it cannot be detected significant histological alterations in size , shape or arrangement of epithelial cells that could be endorsed to aging process.
However , it did not affect TNF-α and IL-6 production.
However , it did show a modestly favorable effect on age-associated LV stiffening.
However , it does have an advantage of being a predominantly reflection emission.
However , it does not affect the level of nuclear hTERT and has no effect on telomerase activity and telomere length.
However , it had no significant effect on the Ca ( 2 + ) level.
However , it has been found that even healthy adults are not always able to learn how to regulate their brain activity during EEG-IC.
However it has been observed that most patients believe that PCI will reduce their risk for death and myocardial infarction.
However , it has been rarely validated in older adults and sporadically used in aging and health studies.
However , it has been shown repeatedly that vehicle approach speed has a substantial influence on the size of chosen gaps.
However , it has been suggested that compared to younger subjects , elderly AMI patients are less likely to receive evidence-based treatment.
However , it has not been elucidated whether long-term postoperative medical treatment is crucial to all patients until menopause.
However , it has not been explored sufficiently how such a regulatory response could be exploited for anti-inflammation.
However , it has not been shown whether the above relationship could be extended to healthy populations.
However , it has only partially been exploited to shed light on these fundamental biological processes.
However , it has poorly been investigated.
However , it has recently been reported that the epidermally expressed transient receptor potential vanilloid @number@ channel is involved in heat- and UV-induced skin aging.
However , it has recently been suggested that possession of the ɛ4 allele may benefit cognition in early adulthood.
However , it has yet to be demonstrated that the inclusive fitness benefits associated with grandmothering are large enough to warrant this explanation.
However , it impacted on the differentiation potential toward the adipogenic or osteogenic lineage.
However , it improved after treatment intervention.
However , it is 15-20% of all smokers who develop COPD.
However , it is a deep-seated brainstem nucleus without clear imaging or electrophysiological markers.
However , it is also believed to contribute to cancer progression.
However , it is also important to identify tumor specific mutations that may determine response to treatment and prognosis for the disease.
However , it is also overexpressed in many cancers and regulates tumour progression by increasing migration , invasion and cancer stem cell self-renewal.
However , it is also present in some cognitively normal elderly adults and may represent a preclinical disease state.
However it is believed that chronological age is not enough to guide management in elderly cancer patients.
However , it is certain that AD is a kind of diseases resulting from multi-causes.
However , it is clearly necessary to continuously observe variation in cancer incidences.
However , it is commonly believed that epigenetics , and specifically DNA methylation alterations , likely play a role.
However , it is commonly described using polynomial models , which may not necessarily be optimal.
However , it is currently unknown if proteolysis through the E3 ubiquitin ligases and the autophagic lysosomal pathway is dysregulated in inactive frail older women.
However , it is currently unknown whether the decline in endothelial vasodilatation with advancing age is due to elevated ET-1 vasoconstrictor activity.
However , it is DM that drives changes in perceived health and functional ability.
However , it is evident based on our results that combining MRI data with cognitive test results improved the accuracy of the MCI-to-AD conversion prediction.
However , it is far from clear what optimal nutrition is for the general population or specific individuals.
However , it is important to note that freshness of VOOs is not necessarily related to its sensory quality.
However , it is less clear whether APOE E4 status may also be involved in non-pathological cognitive ageing.
However , it is likely that the absence of an emotional response following stressful events may also be problematic.
However , it is more difficult to assess RA activity in the elderly.
However , it is most likely that alterations in both the joint microenvironment and the central nervous system ( CNS ) contribute to chronic pain.
However , it is not clear by which process these targeted agents induce cancer cell death and how to predict such tumor responses.
However , it is not clear how alcohol abuse impacts intracortical bone remodeling.
However , it is not clear how lamins are organized in vivo and how the disease mutations affect lamin organization and functions.
However , it is not clear how reduction of apoE levels after birth would affect amyloid deposition.
However , it is not clear how SIRT1 activity is regulated by intracellular kinases in cells.
However , it is not clear if long-term tactile training might prevent this age-dependent decline.
However , it is not clear if the normal sensibility of the hand is also age-dependent , as the existing studies have major limitations.
However , it is not clear if this association is causal.
However , it is not clearly understood which features change and which remain stable over time.
However , it is not clear what happens among older people with no such ties.
However , it is not clear whether different symptom dimensions of depression have distinct associations with WMLs.
However , it is not clear whether the effect of obesity on the incidence of hypertension varies by sex or age.
However , it is not clear whether the up-regulated miR-495 is related to the pathogenesis of PE.
However , it is not clear yet if there is any clinical benefit from banking cells at a younger age.
However , it is not known whether baPWV predicts cognitive decline ( CD ) in later life.
However , it is not known whether combining caloric restriction ( CR ) with exercise training is better in reducing sLOX-1 levels than CR alone.
However , it is not known whether higher body weight is maintained in the very old and in the years prior to death.
However , it is not known whether LCn-3PUFAs elicit similar anabolic effects in healthy individuals.
However , it is not known whether NHERF-1 plays a role in dopamine-mediated NKA regulation in animal models of hypertension.
However , it is not known whether olfactory and motor function are independently related in late life.
However , it is not known whether or how different ( lifelong ) levels of exposure to dietary iodine influences brain health and cognitive functions.
However , it is not known whether telomere length is related to polycystic ovary syndrome ( PCOS ) .
However , it is not known whether there is a direct association between the two.
However , it is not known whether these changes are causative or a consequence of an underlying ageing process.
However , it is not known whether this represents a global attentional deficit or relates to a specific attentional network.
However , it is not well known how cardiac energy metabolism is altered in diabetic hearts in humans.
However , it is now clear that stem cells suffer the consequences of aging as well.
However , it is now clear that the full range of altered offspring phenotypes includes impaired reproductive function.
However , it is only recently that the ability of autophagy to mobilize intracellular lipid stores as an additional source of energy has been described.
However , it is still controversial how the infections play a role in neurological diseases progression.
However , it is still unclear how the functional connectivity between brain regions causes the decline of visuospatial attention.
However , it is still unclear whether gait speed is associated with the movement velocity of the lower limbs or the movement velocity itself.
However , it is still unclear whether they are also involved in Aβ clearance.
However , it is still unknown whether HF is associated with dysbiosis in gut microbiota.
However , it is still unknown whether reactivation during sleep also enhances subsequent retrieval-related neural oscillations.
However , it is still unknown whether the inhibitory effect of anthocyanins on Akt is associated with the anti-EGFR effect.
However , it is uncertain how tendon fibroblasts are involved in tendon aging and how aging cells respond to IGF-I.
However , it is unclear how far such associations are due to incipient neurodegenerative pathology in the samples investigated.
However , it is unclear if changes in its activity affect platelet activation in vivo.
However , it is unclear if current exoskeletons can reduce energy cost in elderly.
However , it is unclear if increased BG iron content contributes to age differences in hand grasp performance.
However , it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss.
However it is unclear what approach is the most cost-effective intervention in changing long-term physical activity behaviour in older adults.
However , it is unclear what functionally relevant electrocortical processes underlie developmental differences in motor planning and control during multijoint , goal-directed movements.
However , it is unclear whether an association exists in developing countries where living to older age is more selective.
However , it is unclear whether a strategy of exercise combined with alagebrium would improve LV stiffness in sedentary older humans.
However , it is unclear whether A-type lamins interact with chromatin in vivo and whether aberrant chromatin-lamin interactions contribute to disease.
However , it is unclear whether chocolate consumption is associated with risk of DM.
However , it is unclear whether differences in age-related changes in TS are associated with general health.
However , it is unclear , whether extrapituitary FSHβ affects BMP9-induced osteogenesis in MEFs.
However , it is unclear whether folic acid improves vasodilation in other vascular beds during conditions of increased metabolism ( i.e. , exercise ) .
However , it is unclear whether gender differences exist in hypertension management among older adults.
However , it is unclear whether LSF content is equally important for face memory.
However , it is unclear whether neurodegenerative changes in the hippocampus are associated with neuropsychiatric behaviours such as aggression.
However , it is unclear whether prefrontal cortex activation is involved in DTW in older adults with mild cognitive impairment.
However , it is unclear whether such changes occur uniformly along the length of the aorta or vary by region.
However , it is unclear whether there is an effect on GABA neuronal subpopulations in an elderly depressed cohort.
However , it is unclear which demographic , psychosocial , behavioral and health factors are associated with self-perceived uselessness.
However , it is unclear which neurofunctional mechanisms may underlie this aging-related cognitive decline.
However , it is unclear which of the many gait outcomes is most appropriate for each of these purposes.
However , it is unclear which regions of the cerebellum are associated with gait speed and information-processing ability in older adults without overt brain damage.
However , it is unknown how changes to the representation of corticospinal output in the primary motor cortex ( M1 ) relate to such weakness.
However , it is unknown how neural development of these regions relates to the development of face-perception abilities.
However , it is unknown if also bone micro-architecture and strength at the contralateral side are unaffected.
However , it is unknown if mTOR inhibition affects aging or its consequences in humans.
However , it is unknown what developmental changes in the brain lead to improved performance.
However , it is unknown whether aerobic exercise at submaximal intensity has detrimental effects on balance in older sedentary adults.
However , it is unknown whether and to what extent changes in perceived uselessness are associated with mortality risk.
However , it is unknown whether chronic therapeutic doses of ASA are anti-inflammatory in the brain.
However , it is unknown whether exercise training started later in life can reverse the effects of sedentary behavior on the heart.
However , it is unknown whether most of the protein is important for retrotransposition.
However , it is unknown whether protein conformation of skeletal muscle and spinal cord is equally or differentially affected by mSOD1-induced toxicity.
However , it is unknown whether the improvements in survival have extended equally in all ethnic groups.
However , it is unknown whether the increase in life expectancy is simultaneously accompanied by an increase in disability-free life expectancy ( DFLE ) .
However , it is unknown whether the up-regulation of αBC is causative or protective for these pathological conditions.
However , it is yet unknown to what extent AET also improves cognitive and procedural learning capacities , which ensure an optimal daily functioning.
However , it offers the major advantage of allowing multiple samples within a single session and this may be useful under specific circumstances.
However , it often remains unrecognized in most clinical settings.
However , it questions the applicability of LTL dynamics as a predictor of mortality.
However , it remains an open question as to why this link with longevity occurs.
However , it remains an under-researched area particularly within the social sciences.
However , it remains controversial and has not been documented in nonpathologic states.
However , it remains controversial to what extent exercise training ( ExT ) enhances RBCV.
However , it remains to be checked if such a relationship is present in the elderly individuals as well.
However , it remains to be demonstrated whether preventing the accumulation of AGEs and their effects is an important therapeutic option for successful ageing.
However , it remains to be determined whether this extends to the cerebrovasculature.
However , it remains to be determined which skin parameter is associated with atherosclerosis.
However , it remains to be elucidated as to whether lycopene or its metabolites apolycopenoids have protective effects against obesity-related complications including inflammation and tumorigenesis.
However , it remains uncertain whether the prior warfarin use actually increases their risk of bleeding in patients treated with thrombolysis.
However , it remains unclear at what level of heat stress these differences occur.
However , it remains unclear how much of this drift is functional or caused by underlying changes in cell subtype composition.
However , it remains unclear precisely how tumors recruit Tregs to support metastatic growth.
However , it remains unclear whether cilostazol enhances anti-atherogenic properties by promoting reverse cholesterol transport ( RCT ) , a major anti-atherogenic function of HDL.
However , it remains unclear whether genetic effects on gene expression remain stable over time.
However , it remains unclear whether mitochondrial DNA ( mtDNA ) undergoes similar epigenetic changes to regulate mitochondrial gene expression.
However , it remains unclear whether optimism is also correlated to less feelings of loneliness over time.
However , it remains unclear whether oxidised LDL concentrations differ with the physical activity status in older adults.
However , it remains unclear whether physiological aging affects the functional integrity of pre-attentive phonological discrimination.
However , it remains unclear whether resistance training can restore impaired steroidogenic enzyme expressions in older individuals.
However , it remains unclear whether white matter microstructure in these regions is associated with age-related decline in EF and / or CPS.
However , it remains unknown whether a causal relationship exists between ataxin-7 proteolysis and in vivo SCA7 disease progression.
However , it remains unknown whether baseline arterial stiffness is independently associated with improvement in functional abilities after exercise training.
However , it remains unknown whether purpose in life protects against the risk of cerebral infarcts among community-dwelling older people.
However , it remains unknown whether such short periods of disuse also induce impairments in metabolic function within skeletal muscle.
However , it remains unknown whether these sleep parameters could serve as markers of cognitive decline in PD.
However , its activity needs additional study to confirm its functional application in foods and cosmetics for protecting skin.
However , its antiplatelet and antithrombotic activities have not been described.
However , its application in Asian skin has not been widely reported.
However , its biochemical and physiological function is still under debate.
However , its biological determinants remain largely unknown.
However , its biological effect on tau protein is unknown.
However , its clinical impact is not well understood and its protean symptoms make it difficult to diagnose.
However , its clinical significance and biological function in nasopharyngeal carcinoma ( NPC ) remain unknown up to now.
However , its contribution to breast cancer remains controversial.
However , its contribution to other aspects of cutaneous biology is currently unclear.
However , its contribution to the pathophysiology of Alzheimer disease is unclear.
However , its detrimental effects on human skin cell remain unclear.
However , it seems that cataract could be a multifactor disease because of its individual , familiar , racial and gender expression differences.
However , it seems that targeting several cell-death pathways is better than targeting the only oxidative stress pathway.
However , it seems that these diseases have a different genetic background.
However , its effect has not been explored in middle-aged smokers with a longer history of smoking.
However its effectiveness in elderly population is yet to be demonstrated.
However , its effect on cerebrospinal fluid ( CSF ) AD-biomarkers has not been investigated.
However , its effect on platelet aggregation , a critical factor in arterial thrombosis , remains unclear.
However , its effect on the anti-inflammatory activity in human dermal fibroblasts ( HDFs ) and the mechanism underlying this effect are unknown.
However , its functional components and boundaries have not been precisely defined.
However , its high prevalence of ~5%in the Caucasian population might be related to an unknown evolutionary advantage.
However , it should be emphasized that during the 3-Tier pilot the screening tools were applied to drivers of all ages.
However , it should be mentioned that IR has both beneficial and harmful effects in biological systems.
However , it should be recognized that the number of studies on benefits of T supplementation is too limited to draw final conclusions.
However , its impact upon disability is unknown.
However , its imperfect sensitivity and specificity have highlighted the need to improve the analysis of MRI data.
However , its inclusion in the model did not increase the amount of outcome variation explained beyond that already explained by the effect of time.
However , its influence diminishes as the size of the public health sector on GDP expands , reaching a maximum around the @number@ %.
However , its longitudinal effects on cognition and brain volumes , both global and regional , in late life are unclear.
However , its low bioavailability upon oral ingestion and lack of specificity may hamper the translation of the encouraging experimental data into human health benefits.
However , its mechanism has never been clearly described.
However , its mechanism of action and whether it regulates telomere length in human remained unknown.
However , its mechanism of action on improving cartilage repair remains to be determined.
However , its multiple anti-photoaging effects remain to be elucidated.
However , its neurobiological origin is poorly understood.
However , its neuroprotective mechanisms against cerebral ischemia injury are poorly understood.
However , its pars facialis , mandibularis , and modiolaris have been underappreciated.
However , its pathogenesis remains largely to be determined.
However , its precise effect on visual attention is difficult to discern from behavioural studies alone.
However , its presence may also be an indicator of a degenerative state of neuritic compartments.
However , its protective role against extracellular amyloids was largely unknown as its presence outside the cells is very limited.
However , its relationship with neuroendocrine activation and endothelial dysfunction in CHF has not been previously studied.
However , its role in hematological malignancies is complex.
However , its role in hip fracture prevention is not established and high consumption may adversely influence risk by increasing height.
However , its role in prostate cancer remains elusive.
However , its severity is often out of proportion to changes in cardiac output.
However , it suffers from a lack of standardization and often produces subjective / vague diagnoses.
However , its utility is impeded by the large number of genetic variants detected.
However , its value in laparoscopic colorectal surgery is unclear.
However , it's worth noting that arrhythmia is a common complication during the perioperative period.
However , it took ~25 years for complete cortical recovery in affected areas for those at the mean pack-years value in this sample.
However , it uncovered an unexpected large region of GM atrophy in the posterior tertiary cortices.
However , it was associated with the development of a secretory phenotype , indicating incipient cell senescence.
However , it was found that lower fluid intelligence scores were related to higher hearing thresholds.
However , it was intuitively perceived that hypertension may follow rather than explain this nephrovasculopathy.
However , it was not possible to recruit the study population for a smoking cessation course.
However , it was the state of not living well that reflected the most substantial vulnerability for mortality , not chronic disease.
However , it was unclear how SNX27-dependent γ-secretase inhibition could contribute to brain development and pathophysiology.
However , Japan is at great risk for future natural disasters because of its Pacific Rim location.
However , kbWF does not eliminate slow components of artifacts whose duration is comparable to the total recording time.
However , key issues such as implantation techniques , immune rejection , and xeno-free techniques are still needed to be further investigated.
However , knowledge of evidence-based health care in this group is still poor.
However , knowledge of the contribution of elders ' social participation and intergenerational solidarity to wellness is scattered and needs to be synthesised.
However , knowledge of the intrinsic effects of ageing on cellular calcium handling in the human heart is sparse.
However , knowledge regarding whether distance travelled from home to the injury site or road environmental / socioeconomic factors affect injury severity remains limited.
However , knowledge translation tools need further development to be used in low-income countries and in the field of ageing.
However , lack of a validated wandering measure in Taiwan has limited scientific investigation and clinical practice.
However , larger proximal joint rotation in elderly group induced larger COM sway envelop and therefore loss of the compensatory strategy of posture recovery.
However , larger studies are required to confirm these findings.
However , larger studies in other ethnic populations are warranted to determine the role of these gene variants in the etiology of metabolic syndrome.
However , large studies are needed to disclose or exclude potential weak associations of these SNPs with CAG risk.
However , lasers and LEDs may offer some disadvantages because of dot-shaped ( punctiform ) emission characteristics and their narrow spectral bandwidths.
However , Latinas are a heterogeneous group with individuals having different proportions of European , Indigenous American , and African genetic ancestry.
However , leave-one-out cross-validation reduced sensitivity in both models and particularly reduced specificity for NCRA.
However , legitimate data based on nc886's correct identity for its functional cellular roles as a tumor suppressor have not been provided yet.
However , leptin levels were sensitive to a depletion of catecholamine stores in both remitted bulimia nervosa and controls.
However , less attention is paid to counseling patients on options for mitigating extrinsic factors related to aging.
However , less is known about age-related change in the secondary somatosensory cortex ( SII ) .
However , less is known about age-related changes in motor planning.
However , less is known about male sex steroids and brain damage.
However , less is known about the antecedents of subjective age and the mechanisms underlying the relationship between feeling younger and positive developmental outcomes.
However , less is known about the efficacy of this strategy in the treatment of schizophrenia-like cognitive disturbances.
However , less is known about the functional correlates of cortical control of gait.
However , less is known about the influence of age on the reactivity of the prefrontal cortex ( PFC ) to acute stressors.
However , less is known about the longitudinal association of leptin and adiponectin with fracture.
However , less is known about the relationship between occupational PA and disability in old age.
However , less is known about the role of sports clubs and physical activity in preventing and managing frailty in older adults.
However , less is known regarding how external force altered the way functionally connected brain structures of the episodic memory system interact.
However , less is understood regarding the influence of neighborhood conditions on health and well-being , particularly in older African-American adults.
However , less than half of the examined seniors met the Global Recommendations on Physical Activity for Health.
However , less work examines within-person SOC variation.
However , level of education , employment status , and place of residence failed to predict psychological well-being.
However , levels of sex hormones change with age.
However , lifelong dynamics of H3 variant replacement and the impact of this process on chromatin organization remain largely undefined.
However , lifestyle factors which cause age-related decline in UFOV remain poorly understood.
However , limitations of existing cognitive screening tests are present and cognitive screening tests should not be used as a replacement for comprehensive neuropsychological testing.
However , limited and conflicting data hamper the conclusive opinion regarding this relationship.
However , limited available information concerning the biological activities of its leaves has been reported.
However , limited bioavailability of curcumin prevents its clinical application.
However , limited data are available on the association between nut intake and all-cause mortality.
However , limited data are available on the pharmacokinetics of this drug in children.
However , limited data exist investigating ethnic disparities in stage-specific GC incidence and survival in the USA.
However , limited data exist regarding mitochondrial dynamics in aging human skeletal muscle and the influence of exercise.
However , limited data exists for these associations among older adults especially in terms of relationship quality in partnerships.
However , limited epidemiological studies have attempted to describe the spatial variation of the geo-referenced data on hypertension disease over an urban area of China.
However , limited information is available about whether chronic illness is already present prior to retirement , or has developed subsequently.
However , limited information is available for elderly nursing home populations , particularly about specific cause of death.
However , limited information is known about the neuropsychological functioning of adults with CHD.
However , limited research has been conducted to understand health literacy levels among Chinese American older adults.
However , limited research has evaluated patterns ( across specific timed intervals ) of performance on tasks of language fluency in different forms of dementia.
However , limited specificity implies many false-positive results which means that these instruments cannot be used as accurate single tests to identify frailty.
However , links between NF-L and TDP-43 expressions are unclear.
However , literature on neuromuscular activation and associated spine and hip kinematics in older individuals is sparse.
However , literature on operative outcomes after CRC procedures in the oldest old is focused primarily on operative mortality.
However , little attention has been given specifically to balance training in older adults with very poor balance.
However , little attention has been given to the potential impact of this nonphysiologic positioning on patients , specifically intraocular pressure ( IOP ) .
However , little attention has been paid to personality variables that are associated with the capacity to effectively utilize social support.
However , little attention has been paid to this need in the biogerontological field.
However , little attention has been paid to whether and how their usage can be sustained over time.
However , little basic research has been performed to address their effect on dermal skin fibroblasts.
However , little data exists on ambulatory blood pressure ( ABP ) and measures of vascular stiffness in the black African HIV infected population.
However , little data is available.
However , little information exists about the clinical relevance of such changes.
However , little information is available on age-related changes in dynamic motor capacity of individual fingers.
However , little information is available on the incidence and clinical outcome of CIN for the elderly patients in Japan.
However , little investigated aspects are the perceptions and experiences of older adults regarding the use of these facilities.
However , little is currently known regarding the combined effects of aging and cancer on DC and T cell inhibitory molecules / pathways.
However , little is known about age- and gender-related changes in circulating MAIT cell level and function in healthy population.
However , little is known about age-related changes within the Ventral Attention Network ( VAN ) , which underlies selective attention.
However , little is known about a possible direct effect of glycation upon cell differentiation.
However little is known about clinical outcomes of AFFs.
However , little is known about comorbid depression and tuberculosis in the general population.
However , little is known about compliance in the NH population.
However , little is known about elimination of the ubiquitination signal after repair is completed.
However , little is known about habitual PM , which involves remembering to carry out intended actions that are regular and repeated.
However , little is known about how age might affect sensitivity to motion during pursuit.
However , little is known about how information pertaining to age-associated diseases is disseminated on popular social media platforms.
However , little is known about how KLF4 regulates TERT expression.
However , little is known about how much coffee and polyphenol consumption influences skin health.
However , little is known about how scan acceleration affects the power to detect longitudinal brain change.
However , little is known about how the daily oxidative stress of the skin is related to skin aging-related alterations in vivo.
However , little is known about how these changes reflect upon the dynamics of the underlying biological system.
However , little is known about how they themselves perceive control in health care.
However , little is known about how this ability changes with age.
However , little is known about its exact prevalence among elderly adults , and often albuminuria is not included in the definition of CKD.
However , little is known about its genome-wide patterns and potential role in AD.
However , little is known about its neurobiology.
However , little is known about multimorbidity patterns and other issues surrounding chronic diseases.
However , little is known about oxidative stress in mild cognitive impairment ( MCI ) patients who present a high risk for developing AD.
However , little is known about predisposing factors for the development of new VESC.
However , little is known about proGDNF expression and secretion under physiological as well as pathological states in vivo or in vitro.
However , little is known about secondary informal caregivers , who often share caregiving responsibilities.
However , little is known about substance use in older homeless adults.
However , little is known about systematic changes in these biomarkers across the adult lifespan.
However , little is known about the age-related molecular changes in lipid accumulation and the mechanisms underlying them.
However , little is known about the association between cognitive functioning and sexual behavior.
However , little is known about the association between systemic inflammation and preclinical AD pathophysiology.
However , little is known about the association between these conditions and risk of ADRs.
However , little is known about the barriers to palliative care provision for older people within acute hospitals.
However , little is known about the behavioral phenotype of these mice.
However , little is known about the BMI change close to or after AD onset.
However , little is known about the context within which such prescriptions occur.
However , little is known about the effect of testosterone aromatization to estradiol on GH pulsatility and its impact on IGF-1 in older men.
However , little is known about the effects of PA , CRF , and exercise on the brain in the oldest-old.
However , little is known about the effects of this pathology on perceptual processes.
However , little is known about the factors associated with participation in PA in community dwelling adults with dementia.
However , little is known about the factors connected with PLO in home-dwelling older people , even though it is an important topic.
However , little is known about the factors influencing GCC thickness in the general population.
However , little is known about the factors that influence residents ' ability to age in place when experiencing cognitive decline.
However , little is known about the functional variant underlying the latter association or its relationship with the p.R47H.
However , little is known about the genetic and non-genetic sources of inter-individual variation in serum sclerostin levels.
However , little is known about the impact of age or obstacles on the attentional demands of a blind navigation task.
However , little is known about the impact of glaucomatous macular damage on central pattern vision.
However , little is known about the implications of chronic pain and analgesic treatment on multimorbid patients.
However , little is known about the independent effect of circulating factors in modulating key molecular pathways.
However , little is known about the influence of aging on grip strength and bimanual coordination control between hands.
However , little is known about the influence of asymptomatic i.e. latent Toxoplasmosis on cognitive functions in humans.
However , little is known about the involvement of purine metabolism in AD.
However , little is known about their employment and related risk factors.
However , little is known about their impact on social inequalities.
However , little is known about their prevalence and topographic distribution in the general elderly population.
However , little is known about the longitudinal outcome of incident MCI as predicted by late-life ( aged ≥70 years ) mentally stimulating activities.
However , little is known about the long-term outcome in these children.
However , little is known about the mechanisms.
However , little is known about the needs and views of this unique group as they age.
However , little is known about the neuroanatomical distribution and expression of Pen-2 in the central nervous system ( CNS ) of AD model mice.
However , little is known about the physical capacities associated with functional autonomy in older women and men.
However , little is known about the predictors of this initial setting.
However , little is known about the quality of life ( QoL ) of older people living alone in Mainland China.
However , little is known about the quantitative relationship between the levels of sjTREC and age.
However , little is known about the rapidly growing population of women aging with disability.
However , little is known about the rate at which balance declines with age.
However , little is known about the relation between serum PTH levels within the normal range and cardiovascular diseases ( CVD ) .
However , little is known about the relationship between driving cessation and change in cognitive functioning in late life.
However , little is known about the relationship between global or regional brain volumes and cognitive test performance in American Indians.
However , little is known about the relationship between insight , cognitive decline , and other psychiatric or behavioral problems associated with AD.
However , little is known about the relative contribution of genetic and environmental effects on different diffusivity indices among late middle-aged adults.
However , little is known about the role of the amino-terminal inserts and how the 0N , 1N and 2N tau species differ.
However , little is known about these changes in the early stage of gestation.
However , little is known about the specific challenges older adults face maintaining CKD self-management regimens.
However , little is known about the transcription factors that epigenetically regulate keratinocyte response to UVB.
However , little is known about the underlying neuronal integrity of the semantic network in normal aging.
However , little is known about the validity ( and consequently the clinical utility ) of subjective reports of prospective memory difficulties.
However , little is known about whether aging affects human Th17 cells.
However , little is known about whether or how much offenders ' risk diminishes as a result of aging.
However , little is known about whether polymorphisms in genes that process microRNAs influence response to pollutant exposure.
However , little is known about whether poor oral health is associated with the progression of lacunar infarction.
However , little is known about whether this source memory decline is associated with neural activity changes.
However , little is known of how BOLD variability and task performance may relate.
However , little is known of the association of these two disorders in the HIV population.
However , little is known of the genetic features of the parasite in humans.
However , little is known on the correlates of SCD in mild cognitive impairment ( MCI ) .
However , little is known regarding health effects in humans.
However , little is known regarding the association between diet quality and asthma.
However , little is known regarding the influence of nephrotoxicants , such as Hg , on aged kidneys.
However , little is known regarding the significance of different EM definitions with respect to health outcome.
However , little is known whether repeated measurement of risk factors can provide better explanation of socioeconomic inequalities in health.
However , little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation.
However , little research has been conducted to compare use versus nonuse of these medications in terms of health-related outcomes in routine practice.
However , little research has been conducted to evaluate the prescription status of drugs for such diseases in Japan.
However , little research has been conducted to gain insight into how these new care models influence healthcare staff's work environment.
However , little research has examined what factors of administrators are associated with how they influence care.
However , little research has focused on skin cancer prevention among the rapidly growing Hispanic population.
However , little research has outlined to what extent relevant and irrelevant emotional stimuli bias the imbalance between affective processing and cognitive control.
However , little was known about the quantitative relationship of ERCC1 and XPF expression levels with age.
However , living with children was positively associated with elders ' mental health after controlling for demographic variables.
However , local data on incidence and risk factors for stroke amongst women are scarce.
However , longevity is not necessarily an indication of disability-free aging.
However , longitudinal and experimental studies are needed to strengthen causal inferences.
However , longitudinal changes in aortic stiffness have not been characterized in CTD patients.
However , longitudinal data on the association between CSVD and depressive symptoms are scarce.
However , longitudinal decline in global cognition over time was primarily associated with older age and poorer everyday function at baseline.
However , longitudinal patterns of weight change during and after treatment , and associated factors , are less well elucidated.
However , longitudinal studies of depression in nursing home residents are scarce and the sample sizes are small.
However , longitudinal studies reported that many adults display LTL lengthening.
However , long-lasting over-activity of the SNS and immuno-metabolic alterations usually lead to an irreversible stage of cardiovascular disease.
However , long-term changes in respiratory function and symptoms in individuals who were exposed to air pollution in the 1960s have not been well studied.
However , long-term cycling does not preserve femoral neck aBMD.
However , long-term expansion is difficult for hSKPs in vitro.
However , long-term in vitro culture is associated with reduced stem cell characteristics and differentiation capability.
However , long-term risks of PUVA are premature skin aging and development of nonmelanoma skin cancer.
However , long-term survival of a subset of skeletal myofibers also occurs.
However , loss of A20 in B cells lowers their activation threshold and enhances proliferation and survival in a gene-dose-dependent fashion.
However , loss of dentin-bonded interface integrity and bond strength is commonly seen after aging both in vitro and in vivo.
However , loss of muscle mass or function can also occur , which is associated with poor prognosis and termed ' sarcopenic obesity'.
However , lots of medicines were chemosynthetic , and they would do a bad side-effect on human body.
However , low back pain is much more common and occurs in approximately @number@ % of people sometime during their lifetime.
However , low WAZ is not a suitable indicator for commencing an extra feeding program , because it reflects stunting instead of wasting.
However , LUTS are not related to depression.
However , LysM-Cre-mediated Eng deletion in the embryo did not cause AVM in the postnatal brain even after VEGF stimulation.
However , M30 has both neuroprotective and neurorestorative activities for nigrostriatal dopamine neurons in post-lesion MPTP , lactacystin and 6-hydroxydopamine animal models of PD.
However , maintaining a self-regulated life at old age involves a high degree of risk , and the elderly often fail at this goal.
However , males were more likely than females to be ' average R / S. '
However , mammals lack fRMsr and are characterized by deficiency in the reduction of free methionine-R-sulfoxide.
However , many additional factors affect the repertoire such as homeostatic turnover and antigen-dependent expansion in response to infection.
However , many aspects regarding the regulation and interplay of these pathways are insufficiently understood.
However , many aspects related to mtDNA methylation are still unclear.
However , many basic questions concerning their mechanisms of action after systemic infusion remain unanswered.
However many clinical and biomarker studies report cases with a single neurodegenerative disease.
However , many dentists believe that their dental education did not adequately prepare them to treat an older adult population.
However , many do not seek treatment and may suffer from the stigma of the illness , which may vary across cultures.
However , many key players were not involved , and ongoing data collection to assess teen pregnancy and prevention efforts was limited.
However , many medications for relief of dry mouth , such as parasympathomimetic ( cholinomimetic ) drugs , have serious adverse effects.
However , many of the associations were relatively weak and further replication of overall and sex-specific associations is warranted.
However , many of the long-term outcomes of childhood obesity have yet to be studied.
However , many of them continue to smoke.
However , many of these changes have been reported at molecular concentrations higher than physiologically achievable levels.
However , many of these morbidities go unreported and are not diagnosed early ; therefore , opportunities for early intervention are missed.
However , many older people accepted these risks and continued eating raw fish , as they know effective drug treatment is available.
However , many older people face a lack of motivation in addition to other strong barriers to exercise.
However , many people fail to meet PA recommendations.
However , many physicians continue to prescribe benzodiazepines and patients wishing to withdraw receive little advice or support.
However , many previous studies on this topic used insensitive oral indicators or did not include certain essential covariates.
However , many properties of TIL are not fully understood.
However , many questions about how a controlled caloric restriction intervention affects aging-related processes are still unanswered.
However , many studies draw conclusions about this relationship without explicitly examining the empirical evidence.
However , many studies have shown that delay screenings still use text-based screening survey questionnaires.
However , many studies of aging do not examine the cases to exclude demented people.
However , many studies record infant EEG only during one baseline condition.
However , many technical , clinical , ethical , and societal challenges should be addressed before such technology is widely deployed in pediatric practice.
However , markers for extrathymic T cell maturation in the mucosa were not different between controls and IBD patients.
However , maximal dynamic strength ratios appear to be less sensitive to differences in site-specific MTH ratios.
However , mean BC-TEOAE levels were reduced by @number@.8-3.7 dB depending on frequency.
However , mean GSR increased on inclines , @number@ ( @number@ ) steps / m , P @number@
However , mean regression analyses may not capture associations that occur primarily in the tails of the outcome distribution.
However , mean SNAP amplitude of UN from fifth finger was higher in females.
However , measurement is not always feasible in clinical settings.
However , measurement of SMI is difficult for general physicians because it requires special equipment for bioelectrical impedance assay or dual-energy X-ray absorptiometry.
However , measures of absolute risk difference indicated a less favourable safety profile of prolonged DAPT for older rather than younger patients.
However , measures of response time produced significantly larger effects of age than measures of accuracy on spatial performance.
However , mechanisms by which aging exerts its negative effect on outcome have been only partially clarified.
However , mechanisms for cosmetic improvement have not yet been completely determined.
However , mechanisms mediating EC barrier regulation in the context of aging remain unclear.
However , mechanisms regulating the endosome-to-trans-Golgi network ( TGN ) retrieval of BACE1 remain unclear.
However , mechanisms underlying their radiochemoresistance remain obscure.
However , mechanistic details delineating how DJ-1 regulates PTEN activity remain unknown.
However , medial temporal tangles were related to age independent of neuritic plaques.
However medical costs of physician-led home visits care have not been well studied.
However , men and women demonstrated different cortisol responses ; men showed a robust response to both tasks , and women displayed a lesser response.
However , men and women exercised for different reasons.
However , men and women handle the problem variedly showing gender differences in coping strategies with better coping mechanisms in women.
However , men with more pronounced symptoms indicating mental disorder did not have lower testosterone levels.
However , metabolites that impact neutrophil inflammasome remain unknown.
However , methodological issues and sample size must be considered when designing and evaluating these studies.
However , methodological weaknesses including population and intervention heterogeneity do not allow for comprehensive meta-analyses to determine the clinical value of individual approaches.
However , MetS subjects were less likely to die during study period ( @percent@ vs. @percent@ , P = 0.059 ) .
However , MHY-449 did not show any significant effects on the growth inhibition and apoptotic cell death in androgen-dependent and p53-wt LNCaP cells.
However , middle-aged to old Neil2-null mice show the accumulation of oxidative genomic damage , mostly in the transcribed regions.
However , MI NF protocols have been largely optimized only in younger healthy adults , although strokes occur more frequently in older adults.
However , minority aging populations are often underrepresented in most studies on cardiovascular and pulmonary symptoms.
However , miRNAs showing common effects across tissue types may represent those associated with core , rather than tissue-specific senescence processes.
However , mitochondria go through a series of morphological and functional alterations during carcinogenesis.
However , mobility limitations can restrict opportunities to perform these occupations , which may affect quality of life.
However , moderators of change differed somewhat for those in the engagement and training interventions.
However , modern lifestyle and advances in technology have increased the percentage of individuals working in phases misaligned with natural circadian activity rhythms.
However , modulation of P-glycoprotein , rather than antioxidant and anti-inflammatory effects , could be the major mechanism of polyphenolic compounds , including flavonoids.
However , molecular details of the selective mitochondrial fusion are less well understood.
However , M. oleifera from Cambodia has never determined.
However , morbidity and mortality figures indicate that current anti-platelet strategies are far from a panacea.
However , more and more older adults adopt different kinds of ICTs in order to fit in with the society.
However more complex FDM , such as making decisions in accordance with specific rules , becomes more difficult with advancing age.
However , more complex interventions have also been developed and tested to achieve more sustained improvement in balance confidence.
However , more conclusive data are needed to verify or disprove these hypotheses.
However , more controversy exists regarding higher exercise loads such as those imposed by elite-sport participation.
However , more evidence is needed to determine its effectiveness as an alternative exercise to promote fitness in older adults.
However , more general anisotropy models like Q-ball imaging ( QBI ) may provide more sensitive WM descriptors in single patients.
However , more high-quality RCTs would be useful to clarify the effect of n-3 fatty acid supplements on cognition.
However , more intensive and / or supervised exercise intervention may be needed for those with MetS.
However , more investment has been made into research into interventions to prevent mental illness than into those designed to improve mental wellbeing.
However , more often than not , administration of antioxidants is ineffective , suggesting that our current understanding of the underlying regulatory processes is incomplete.
However , more outgrowths were derived from SCNT blastocysts developed in the presence of a p53 inhibitor , indicating a beneficial effect on trophectoderm function.
However , more pronounced reduction was found in bone mass than in muscle mass in the subjects with lower bone mineral density.
However , more psychometric analysis are needed to guarantee the usage of tests for assessing cognitive reserve.
However , more research about prevalence of peanut allergy is warranted in developing countries.
However , more research is needed to identify men's unmet health-care needs and to develop optimal strategies for addressing them.
However , more research is needed to inform best practice guidelines to meet the needs of this growing TBI population.
However , more research is required in order to evaluate GAS , as research conducted in other health care settings may provide important additional findings.
However , more research seems mandatory.
However , more studies are needed to better understand whether DM treatments affect this relationship.
However , more studies controlling for potential confounders are necessary.
However , more work is needed to clarify the nature and mechanisms of these deficits.
However , morphologic , molecular , and genetic studies indicate that this subdivision is a misleading oversimplification.
However , mortality beyond that age was predicted neither by functional status nor biomedical measurements , indicating alternative trajectories of mortality at the highest ages.
However , mortality due to non-AIDS conditions and particularly cardiovascular events seems to be on the rise in this population.
However , MoS increased ( p < 0.05 ) in both groups within the disturbed trials , indicating feedback adaptive improvements.
However , most aging males refuse to seek medical help and believe that ED is an irreversible event in the aging process.
However , most community-dwelling persons with dementia are cared for in primary care settings where a more in depth pain assessment is unlikely.
However , most conventional groupwise registration methods do not explore the data distribution during the image registration.
However , most evidence for dysfunctional neural plasticity in depression has been indirect.
However , most falls remain unwitnessed events.
However , most hearing-impaired adults delay obtaining treatment.
However , most initiatives aimed at reducing the use of these medications have overlooked assisted living ( AL ) settings.
However , most intervention studies of supplementation with n-3 PUFA have yielded disappointing results.
However , most literature is based on self-reported PA which is limited by recall bias.
However , most lymphocytes reside in tissues.
However , most of the lifetime risk estimation came from the studies based on western population.
However , most of the miRNA expression variability that correlated with the presence of early AD-related pathology was seen in GM.
However , most of the NKG2D + cells belonged to the CD28 ( null ) compartment and shared their phenotypical properties.
However , most of these proxy markers are not or insufficiently representative of maximum force.
However , most of these theories do not consider plants , and the specific traits involved in their ageing mechanisms.
However , most of the studies have focused on adolescence and adulthood.
However , most patients will need two or more drugs to reach the recommended goals.
However , most people with a chronic disease feel healthy , have no disabilities and participate fully in society.
However , most recommendations are based on extrapolation from findings in younger patients.
However , most research focuses on industrialized populations with widespread access to formal schooling , high testosterone , and low parasite and pathogen load.
However , most research has focused on reach adjustments following changes in target location.
However , most studies do not account for the changes in body weight expected to occur as women age.
However , most studies examining the effect of somnolence on brain function focus on acute sleep restriction in young adults.
However , most studies exclude those with undiagnosed dementia.
However , most studies had a high risk of bias and small sample sizes.
However , most studies have been constrained by cross-sectional designs that limit causal inference due to failing to establish temporal order of exposure and disease.
However , most studies have been done using self-reported PA.
However , most studies investigate age effects by comparing young and elderly subjects and do not provide a model within a target age range.
However , most studies use just one marker at a time , sometimes leading to conflicting results due to complex interactions among the markers.
However motility , morphology and DNA fragmentation are not affected by male age.
However , motor learning has not been quantitatively evaluated clinically.
However , MRI provides an indirect measurement of the biological signals we aim to investigate.
However MS patients remain disadvantaged relative to the general population and changes in age at death are not reflected in decreased mortality rates.
However , MTL volumetry revealed that anterolateral entorhinal cortex ( alERC ) volume-the same region in which Alzheimer's pathology originates-was strongly associated with MoCA performance.
However , much evidence is still needed as Asian countries have great diversity in culture , societal values and men's needs.
However , much less is known about the longitudinal association between direct measures of cardiorespiratory fitness and cognitive function across the life span.
However , much less recognized has been the aging associated pathogenesis of this disorder.
However , much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes.
However , much of the research has focused on the general older population , with no research to date focusing on minority populations.
However , much of the work to date suffers from four limitations.
However , much of this evidence is cross-sectional with little known about longitudinal associations.
However , MUDs also achieve acceptable outcomes and long-term disease control.
However , multimorbidity and serious DDIs are usually not addressed in these.
However , multiple strategies can maximize this value.
However , multiyear mean HbA1c is not always available in the clinical setting.
However , muscle co-activation of the lower extremity showed a significant negative correlation with gait speed based on age.
However , muscle strength is not restored.
However , mutations in centriole biogenesis genes have been reported in primary microcephaly and Seckel syndrome , disorders without the hallmark clinical features of ciliopathies.
However , navigational skills are not typically measured in most test batteries assessing cognitive aging.
However , navigation in a virtual maze relies on spatial or response strategies known to depend on the hippocampus and caudate nucleus , respectively.
However , nearly two-thirds ( @percent@ ) of treated hypertensives had suboptimal control.
However , negative correlations between miR-20b-5p and the protein levels of its predicted target , acyl-CoA synthetase long-chain family member @number@ were observed.
However , negative emotion symptoms were not the mediators between CPAP adherence and the intimate relationship.
However , negative tumor markers do not exclude the possibility of malignancy.
However , neither abnormal C9orf72 expansion nor pathogenic MAPT or GRN mutation was found.
However , neither age nor operating time had influence on the complication rate.
However , neither lymphocyte subpopulations nor BDNF levels changed following the intervention.
However , neither the gender nor the age effect was present regarding the CRT index.
However , neither ε2ε2 nor ε2ε4 affected AD risk.
However , nematodes diverged from other animals between @number@ and @number@ million years ago.
However , nesprin genes are complex and generate many variants , which occupy various sub-cellular compartments suggesting additional functions.
However , neurological disorders span across a wide spectrum and individual variations exist in within populations of the same disease.
However neuroprotective drugs such as corticosteroids proved partially effective.
However , new epidemiologic and clinical data have shown that high level of fat mass might be a risk factor for osteoporosis and fragility fractures.
However , newer fractional CO ( @number@ ) laser technology has reduced the recovery time and led to decreases in postprocedural hypo- and hyperpigmentation.
However , newly generated preOLs fail to differentiate and initiate myelination along their normal developmental trajectory despite the presence of numerous intact-appearing axons.
However , new products with interesting features are being introduced into the market.
However , new studies are starting to uncover the possible beneficial effects of lipids working as signaling molecules on health and longevity.
However , no AD models have fully validated this hypothesis.
However , no animal model of AS has yet been available.
However , no association could be confirmed between longevity and these SNPs or haplotypes inferred from them.
However , no associations were observed with measures of cognitive and physical capability.
However , no consensus exists as to how to best quantify muscle function in older adults.
However , no consistent change in the EEG-BOLD correlations was identified that would correspond to the neuronal maturation captured by the EEG.
However , no correlation between these tests and a retention loss or marginal integrity was shown.
However , no correlation was found between serum T level and kidney stones.
However , no current tools can distinguish erroneous barcodes from PCR or sequencing errors in a data preprocessing step.
However , no data are available on its effects on behavior and tau metabolism.
However , no data are available on the use of different reference frames within topographical space in aging.
However , no data exist concerning the importance of Tregs for a successful outcome following assisted reproduction technologies.
However , no definitive candidate causes have been identified.
However , no difference in ARMA-ARI was found between the groups.
However , no difference in EBV viral load among the frailty status subgroups was found.
However , no difference in slow wave sleep was observed ( @percent@ ; not significant ) and no correlation was found with performance.
However , no differences between groups were apparent after 48h of recovery.
However , no differences in patient survival were observed among different regions of residence.
However , no differences were found in other diffusion tensor imaging indexes.
However , no differences were observed after consuming either S or SS milk in the C allele carriers.
However , no difference was observed between velocity of wheelchair propulsion between groups ( @number@ m / s versus @number@ m / s ) .
However , no directed adipogenic differentiation of this line has been found.
However , no drug is available in the market at present.
However , no firm conclusions can be drawn in respect to the most effective initiatives.
However , no further olfactory impairment was evidenced in THY-Tau22 mice until @number@ months although tau pathology early affected olfactory cortical structures.
However , no further widening of these gradients was found during follow-up.
However , no genotype-related difference in ACVR1B mRNA expression in quadriceps muscle was observed.
However , no glial cells are seen to contain tau in their cytoplasm.
However , no group-related differences ( P = @number@.160-0.573 ) were observed for PT nor absolute and relative RTD at 100-200 ms.
However , no increased structural interference was found for the elderly during performance of the dual-task.
However , no medications against delirium have yet been approved.
However , no mTOR inhibitor has yet been marketed to treat AD.
However , nonadaptive explanations are also plausible , especially for the positive association observed in industrialized societies.
However , none of the approaches utilized have defined the exact cause of the disease or an ultimate treatment for AD.
However , none of the associated SNPs and haplotype remained significant after Bonferroni correction.
However , none of the independent SNPs in these genes predicted mortality.
However , none of the observed symptoms can predict the presence of a reduced rate with cold stimuli in a statistically significant way.
However none of these approaches to date has proven particularly amenable to quantitative analysis of SABG activity in situ.
However , none of these case subjects were linked to a molecular genetic cause.
However , none of these factors can independently predict disease with significant precision.
However , none of these have been universally accepted.
However , none of these is completely effective.
However , none of these parameters responded significantly different between the three age groups.
However , none of the widowers had remarried and of those who described themselves as repartnered only one was cohabiting.
However , no normative values have been established for circulating AMH in healthy women.
However , no PD-related trend in the cellular component was present.
However , no previous prospective study has focused on perioperative MACE in this population.
However , no prior longitudinal research has quantified the incidence of EA , which is critical to understand risk factors and future prevention strategies.
However , no publication to date has summarised the overall epidemiological evidence.
However , no randomized clinical trial was found to confirm this suggestion.
However , no reactivation was observed after mipafox inhibition with 2-PAM or the more potent oximes used.
However , no references to the preferred combination ART ( cART ) for these patients have been described.
However , no relationships were discovered between mir-146a or mir-149 polymorphism and lung cancer risk.
However , no relationship was observed between the MEDAS and GDS.
However , no relationship with delayed memory was observed.
However , no relevant sex- or age-dependence of cartilage T2 was observed between age 45-78 years.
However , no research has comprehensively examined the effects of overweight or obesity on the feet of individuals older than @number@ years of age.
However , no research has yet focused on the mechanisms through which a youthful subjective age could be related to higher life satisfaction.
However , no research on the effect of study habits at home on the brain structure of children has been conducted thus far.
However , no reviews on the physical benefits of dancing for healthy older adults have been published in the scientific literature.
However , normal human metabolism is altered in many diseases and the therapeutic goal is fundamentally different to retrieve the healthy state.
However , normal S-FGF21 does not exclude structural respiratory chain complex or assembly factor defects , important to acknowledge in diagnostics.
However , normal values of IVC diameter in relation to age have not been investigated.
However , no sex differences were found for the assessed impulsivity dimensions.
However , no significant association was observed between the DDX39B @number@ G / C polymorphism in the cases and controls.
However , no significant changes in MDA and MPO concentrations were detected.
However , no significant changes were found in parvalbumin or calretinin immunostaining in the any other layer of the DLPFC in elderly depressed patients.
However , no significant changes were observed in HRQoL among these residents.
However , no significant correlations were found between the other factors above and BMD for continuous and discrete variables.
However , no significant correlation was detected between the densities of conjunctival basal epithelium or Langerhans cell density and age.
However , no significant correlation was found between the changes in OABSS scores and those in other neuropsychological parameters.
However , no significant differences were found between vitamin and other groups for P3 latency.
However , no significant differences were observed between the age groups.
However , no significant difference was detected after adjusting with BMI as confounder.
However , no significant difference was found when comparing the various correlations with age.
However , no significant difference was observed between LA group and control group in rs9951307.
However , no significant difference was observed in plasma PIPC levels between the @number@ groups.
However , no significant difference was observed in the distribution of each genotype among PCa patients , with respect to tumor grade.
However , no significant effects of DHA supplementation on cognitive functioning were found.
However , no significant effect was observed in the spasticity of the wrist joints.
However , no significant findings could be noted in the ODO group.
However , no significant main effects of group ( fallers vs. non-fallers ) and no significant interaction effects between group and walking condition were observed.
However , no single polymorphism has been reliably associated with variation in intelligence.
However , no studies evaluate the comparative strength of these predictors and the amount of the variance in development they explain.
However , no studies have assessed if HRQOL before diagnosis is predictive for OS.
However , no studies have determined the characteristics of the large population of elderly patients with colorectal tumors.
However , no studies have directly tested the relationship between physical activity behavior and pain modulatory function in older adults.
However , no studies have evaluated the associations between body composition and plasma levels of BNP.
However , no studies have examined these relationships among older adults.
However , no studies have explored the psychometrics of this scale when administered to older adults over the telephone.
However , no studies have investigated the possible relationship between headache severity parameters and lipid serum levels.
However , no studies have reported associations between personality traits and VEGF levels.
However , no studies have reported on a possible association between height and risk of anemia in relation to drinking status.
However , no studies have tracked IL-8 over several shifts or used it for monitoring short-term residual stress.
However , no studies of age-related differences in gait have quantified the percentage of strength and ROM used during gait.
However , no studies to date have examined the impact of HIT on the cerebrovasculature and corresponding implications for cognitive function.
However , no study has demonstrated its relationship with age-related cataract ( ARC ) .
However , no study has examined dynamic aspects of emotion in relation to mortality.
However , no study has examined the influence of age on cognitive improvements after bariatric surgery.
However , no study has focused on early or \ "pretear \ " rotator cuff disease states.
However , no study has reported changes in back muscle fatigue with aging in healthy men and women.
However , no study has used WBC cutoff values to predict MetS in the elderly.
However , no study on the protective effects of sarsaparilla root ( SR ) on human dermal fibroblasts has been reported previously.
However , no such association was found in women.
However , no systematic review of factors that influence an older cancer patient's decision to accept or decline cancer treatment has been conducted.
However , not all MetS components were associated with the same changes in arterial properties.
However , not all people under stress have distinctly short telomeres , and we examined whether exercise can serve a stress-buffering function.
However , not all the clusters of MetS components render the same burden on arterial structure and function.
However , not always can ancestry be ascertained , for example , in the case of badly preserved corpses.
However , nothing is known about the role of the PinX1-TRF1 interaction in the regulation of telomere maintenance.
However , nothing is known regarding the long-term effects of calorie restriction ( CR ) with adequate nutrition on body temperature in humans.
However , nothing is yet known about the impact of MBIs on sleep in older adults with prodromal sleep disturbances.
However , nothing is yet known about the specifics of how PD changes with age and affects health.
However , not much is known about this bias in the field of cancer ( pharmaco- ) epidemiology.
However , no tools have been validated in the Japanese context to evaluate healthcare professionals ' attitudes towards , or readiness for , IPE.
However , noun-cued recall of verbs initiated more new subsequent learning during the first restudy , compared to verb-cued recall of nouns.
However , no universal criteria have been agreed upon to readily identify patients who are likely to benefit from CGA.
However , novel aspects of the participant role were the source of most ethical challenges.
However , now that extensive home care collaboration networks have been formed , provision of end-of-life care at hospitals may be showing a declining trend.
However , no zebrafish models bearing human premature senescence currently exist.
However , @number@ m walking speed was faster in PA versus HE group ( overall P = < .001 ) .
However , @number@ ( @number@ % ) patients were not treated with any anti-dementia drug.
However , @number@ of @number@ analyzed parameters showed CVs > @percent@.
However , number of SPT sessions did affect driving mobility outcomes.
However , @number@ ( @percent@ ) patients were hospitalized because of infection.
However , @number@ serious cases of thromboembolism developed after surgery.
However , numbers of regulatory T cells are dramatically different between the @number@ models of obesity.
However , numerous questions remain unanswered regarding the nature of these age differences and the role of attentional control abilities in dual-tasking.
However , nutritional and genetic interventions to boost anti-oxidants have generally failed to increase life-span.
However , nutritional biomarkers of such decline have not been identified.
However , nutritional knowledge was very minimal in these guidelines.
However , O2 ( -• ) / H2O2 are only dangerous in large quantities.
However , OA knees showed larger lateral bowing with OA grade , which might reduce the condylar-shaft angle and subsequently shifted the mechanical axis medially.
However , obese cohort members exhibited no excess decline in IQ.
However , obese subjects are usually eucapnic , indicating that hypoventilation is not a common cause of their hypoxemia.
However , observational and experimental studies testing neuroprotective effects of physical fitness should consider confounding by neuroselection.
However , observational studies and randomised controlled trials in humans have resulted in inconclusive findings within this domain.
However , observational studies have suggested that storage duration might be associated with increased morbidity and mortality.
However , observational studies on the course of DLL are scarce.
However , observed differences were of small magnitude and further studies are needed to confirm this finding.
However , oenothein B induced IFNγ production by T cells from adult humans and cattle.
However , of special interest was the highly significant and previously not reported independent correlation with fat free mass ( p < 0.001 ) .
However , older adults are not physically active enough.
However , older adults did not break gaze anchoring for either condition.
However , older adults did not show changes in RSFC in the default mode network ( DMN ) .
However , older adults did not vary their grammatical complexity as a function of monetary incentives.
However , older adults exhibited increased reliance on processing in right inferior parietal lobe associated with successful forgetting.
However , older adults generated more external details for episodic future and counterfactual thinking than younger adults.
However , older adults improved their memory performance substantially by two means : self-paced encoding and practice.
However , older adults often lack sufficient eHealth literacy to maximize their benefit from these resources.
However , older adults rarely perform exercise to fatigue.
However , older adults showed decreased memory if the other pair received a contrastive accent ( Experiment @number@ ) .
However , older adults showed evidence of hyper-binding between attended and unattended context features while the young adults did not.
However , older adults were less likely to recognize the critical side effects on a later recognition test , relative to younger adults.
However , older adults were much more impaired by the distractor material than younger adults with reduced visual acuity ( Experiment @number@ ) .
However , older adults were not differentially vulnerable to the inflating effects of imagination.
However , older adults were willing to travel substantially farther than younger adults to meet the right partner.
However , older adults with ID are also at risk of polypharmacy , and older age is a risk factor for development of side effects.
However , older adults with lower proprioceptive error had significantly higher mini-BESTest scores of dynamic balance abilities ( P = .005 ) .
However , older depressed adults may be at increased risk for antidepressant adverse effects.
However , older diabetes mellitus patients are very heterogeneous in their clinical characteristics , diabetes mellitus-related complications and age at disease onset.
However , older individuals may be unaware of what specific physical abilities compromise independent functioning.
However , older methadone patients , just as any other patients , should be accorded treatment appropriate to their medical condition and needs.
However , older patients are more compliant to antiretroviral treatment ; they experience a better virologic response , and treatment represents a positive clinical impact.
However , older patients did not retain this flexibility and were biased toward using only highly skewed V genes at all stages of their response.
However , older patients were more likely to develop infection when using immunosuppressants.
However , older people can be devalued in society through attitudes , practices and beliefs engendered in discourse.
However older women may be reluctant to sacrifice an often recently-gained lifestyle free of caregiving obligations.
However , on a population level , the effects on overall reclassification of CKD status are modest.
However , one of the most fundamental questions remains unanswered : How is load transmitted through the tendon ?
However , one study has demonstrated that older adults are unable to use a retrocue to inhibit irrelevant items from memory.
However , one-third of patients have poor outcome as death , functional decline or quality of life ( QoL ) decline.
However , only a few quantitative studies have been performed to compare upper and lower extremity weight bearing.
However , only a few single nucleotide polymorphisms ( SNPs ) have been reported to be consistently associated with aging.
However , only a few studies have evaluated this problem in elderly Brazilians.
However , only a few studies have examined the association between frequency of breakfast consumption and muscular function.
However , only a few studies of EBV-positive ( EBV ) sBL have been reported , and its characteristics still remain controversial.
However , only age at baseline uniquely predicted longitudinal changes in SDM , such that declines accelerated with greater age.
However , only a minority of cirrhotic patients develop HCC.
However , only a small subset of patients benefits while @percent@ encounter side effects.
However , only atorvastatin increased the glycated albumin levels from baseline ( @percent@ for atorvastatin vs @percent@ for rosuvastatin , p = @number@ ) .
However , only between-groups differences in IOR remained after correcting for age-related slowing in response times.
However , only few of these studies reported on the same risk factors.
However , only few studies have addressed sleep in early childhood.
However , only for the past @number@ years have histones demonstrated that their influence extends far beyond packaging DNA.
However , only guided training tended to reduce falls.
However , only impaired ventricular relaxation could reproduce the increased reliance on active emptying we observed in these patients.
However , only in children the identifiability effect continued for short novels after 300ms.
However , only limited number of studies has been conducted so far focusing the ocular promoting activity of grape polyphenols.
However , only little information is available on the role of ZNF804A regarding the cognitive phenotype of psychosis.
However , only little is known about the individual components controlling autophagy in this aging model.
However , only minor deteriorations in most parameters were observed in obese subjects older than @number@ years of age compared with normal-weight , age-matched patients.
However , only one study has investigated the association between twitch contractile properties and skeletal muscle mass.
However , only partial scalar and uniqueness invariance of the CES-D items was supported.
However , only @percent@ of workplaces were implementing THP programs according to a survey conducted in @number@
However , only PhoRTE demonstrated a significant reduction in PPE , as suggested by the study's causal model.
However , only recently have scientists started to pay special attention to G. lucidum spores.
However , only serial position scores predicted those participants with longer time to conversion.
However , only the breathing group showed improved cognitive function ( abstraction , mental flexibility ) .
However , only the cross-lagged path from youth CUD to adult AUD was significant.
However , only the negative correlations in the overall sample ( i.e. , males and females combined ) remained significant when controlling for multiple comparisons.
However , only the second association retained statistical significance after adjusting for age.
However , only the young adults showed intermediate transfer to two complex working memory tasks.
However , only traditional medicine was considered beneficial in addressing sexual dysfunctions that had spiritual dimensions.
However , only VLDL reduced anchorage-dependent cell death and promoted lung metastasis in nude mice.
However , only younger adults revealed inhibitory mechanisms to compensate for attentional capture.
However , on negatively worded items , participants in a negative mood exhibited lower MSE than participants in a positive mood.
However , on the individual level , the more morningness the chronotype , the more persistent it remains with aging.
However , opportunities to improve health through re-employment or extending working lives are limited as later-life exits from employment are often unwanted and permanent.
However , optimism , perceived stress , and anxiety were correlated in the expected directions with antibody responses to influenza vaccine.
However , organizational alterations of the structural brain network at the system level in aging are still poorly understood.
However , other changes associated with terminal T cell differentiation could not be readily detected.
However , other cyclic AMP ( cAMP ) -elevating agents did not increase ABCA1 gene expression in THP-1 macrophages.
However , other E3 ligases have been identified , such as the chaperone-associated ligase CHIP , although their precise function regarding p53 degradation remains elusive.
However , other evidence suggests that the region is highly heterogeneous and may play a direct role in regulating the focus of attention.
However , other pathogenic post-translational tau modifications have not been well characterized.
However , other pathways exist , such as the p53 pathway.
However , other potential drug risks remain to be further analyzed and more samples should be surveyed.
However , other SNPs , including IL-6 gene SNPs , didn't correlate with age in the Han Chinese population.
However , other studies showed that the frequency of OSAHS-related symptoms in patients with obstructive airway diseases decreases after the age of @number@ and older.
However , other studies yield conflicting findings.
However , other tremors may also occur in ET patients , creating considerable diagnostic confusion amongst treating physicians.
However , our current understanding of molecular and cellular signaling that controls human dopaminergic development and function is limited.
However , our efforts to replicate this experiment were confounded because spontaneous regression of tumors occurred in several of the mice.
However , our findings derived from accelerometer-based measurements suggest that increasing light-intensity activity and reducing sedentary time are also important , particularly for inactive adults.
However , our findings do not confirm previous findings that the SMMSE is a more accurate screening instrument for dementia than the original MMSE.
However , our findings do not provide evidence to indicate that social resources protect against terminal decline in well-being.
However , our knowledge of p-MAPT neuropathology in the fornix is limited.
However , our patients had a typical ALS , without evidence of FTD , cerebellar or extrapyramidal signs , or sensorineural deficits.
However , our results differed in that we found no evidence of premutation-associated executive dysfunction.
However , our results obtained from mouse models and seminoma patients demonstrated the opposite.
However , our results point to associations between the genetic AR polymorphism and vulnerability to depressive symptomatology.
However , our results require confirmation in further studies.
However , our results suggest a weak but negative relationship between TAS and BMD.
However , our simulations suggest that the protective ability of retrograde signalling depends on the efficiency of fusion-fission process.
However , our transition probabilities were estimated from longitudinal , linked administrative health and social care datasets , rather than from survey data.
However , our understanding of educational differences in the control of diabetes and its impact on survival is limited.
However , our understanding of factors that influence the physical activity of residents in the long-term care ( LTC ) setting is limited.
However , our understanding of retinal development in humans remains undeveloped.
However , our understanding of the molecular mechanisms underlying PD pathogenesis is still incomplete , hampering progress in those areas.
However our understanding of the skeletal muscle proteins regulated through acetylation and ubiquitination during muscle atrophy is limited.
However , our understanding of the specific molecular , cellular , and network level processes responsible for mediating sex differences in epilepsy remains limited.
However , our understanding of what causes ALS is not complete , and further genetic research will provide additional detail about its causes.
However , out-migration of adult children is common in these countries.
However , overall , the trend indicates no remarkable increase in the number of publications relative to all areas.
However , over the last years several studies demonstrated that TERT belongs to the group of dual-targeted proteins.
However , over this time , the family's ability to support its older members has been considerably altered and arguably weakened.
However , overweight or obese women were more likely to have a breast self-exam and a Pap smear.
However , oxidation levels almost doubled in near-surface regions when remelted HXLPE samples underwent consecutive cyclic loading , artificial aging , and cyclic loading steps.
However , p53 can also promote aging if constitutively activated.
However , p53-null and p21-null cells were more resistant to the antiproliferative and apoptotic effects of MHY336 than p53-wt cells.
However , pain ( proxy-measured ) and wellbeing level did not reveal any interaction effects between the groups over time.
However , parameter values for the tibial tuberosity-trochlear groove ( TT-TG ) distance in the young patient have not been defined.
However , parietal morphometry remains difficult to assess in vivo.
However , participants had difficulty in applying this knowledge to the clinical setting : assessing , diagnosing , treating , and managing UI.
However , participants self-reported @number@ hr per day more sedentary time on weekdays compared with weekend days.
However , participants stated that this involvement , especially at higher levels , had a negative impact on their social life.
However , participants who received organizational support had a @number@ points of increase on the 15-item Geriatric Depression Scale ( GDS-15 ) .
However , participants with airflow limitation were less likely to report breathing pauses , frequent snoring , EDS , and obesity.
However , participation in a chronic exercise program did reduce the oxidative stress induced by an acute bout of exercise.
However , partner dance involves physical contact between the dancers , and older adults would need to be accepting of partner dancing with a robot.
However , part of this increase could be explained by other factors.
However , past research has focused on assessing overall adherence or adherence to a single index medication only.
However , pathobiological mechanisms of olfactory loss in the elderly are poorly understood.
However , pathophysiological mechanisms underlying knowlesi malaria , and of the age-related increase in risk of severe malaria in general , are poorly understood.
However , patient hemodynamic stability , during these procedures , has not been reported.
However , patient satisfaction levels were high ( @percent@ satisfied or very satisfied ) .
However , patients most in need of such therapies are often of advanced age.
However , patients older than 60-years represent about @percent@ of all patients with malignant middle cerebral artery infarcts.
However , patients with a low sKlotho level ( < 460 pg / mL ) did show CAD and LV dysfunction more frequently.
However , patients with dementia walk too fast for their level of frailty , creating an ethical dimension to rehabilitation and risk.
However , patients with PAD have lower circulating VEGF-A than the control group and higher circulating inflammatory parameters of TNF-α and IL-8.
However , patients with synkinesis have better disease-related quality of life than do those without synkinesis.
However , patterns of costs among component tasks differed across studies and reasons for participants ' resource allocation strategies remained elusive.
However , PDMS is also a chemically and physically unstable material.
However , people in remote areas face difficulties to be scanned due to aging society and physician's shortage.
However , people who were more elderly presented a high risk of falling.
However , perceived loss of control did not significantly mediate the relationship between the receipt of care and depressive symptoms.
However , perceived risk did not differ among the groups.
However , @percent@ of food insecure participants were nonadherent to oral hypoglycemics.
However , @percent@ , @percent@ and @percent@ of persons exhibited > @number@ effect size increase or decrease , or no change , respectively.
However , perception of old age induces mainly strong negative social biases.
However , perceptions of specific factors needed to maintain and promote good health differed between healthy and less healthy participants.
However , performance capacities can be maintained through systematic physical training.
However , persisting senescent cell accumulation and excessive SASP might induce sustained low-grade inflammation and disruption of normal tissue microenvironments in aged tissue.
However , photoaged photography did not alter other teenagers ' intention to tan.
However , physical activity also decreases with age in older persons , and is affected by adverse climatic periods.
However , physical activity as an important health resource lacks dissemination in persons of older age in Switzerland.
However , physical activity significantly differed by genotype.
However , physically active older adults have more compliant large arteries and left ventricles and lower inflammation than sedentary older adults.
However , physician resistance to FPA and PA presents barriers to implementation.
However , plans for treatment of individuals with peanut allergy could be incorporated into these formulated food supplementation programs.
However , plasma and genetic factors relating to cholesterol transport were associated with Aβ deposition in the brain.
However , PLM has yet to be compared with the established noninvasive assessment of vascular health , flow-mediated dilation ( FMD ) .
However , pol ν-disrupted mice have a modestly reduced crossover frequency at a meiotic recombination hot spot harboring insertion / deletion polymorphisms.
However , poorer functional status and occurrence of lower respiratory tract infections were significant predictive factors for all-cause mortality.
However , poor SNRs affected accuracy and reaction time of Match and No Match word pairs differently.
However population data are scarce , and no studies have controlled for neuroticism.
However , population level survival has been lower , especially in older patients.
However , populations with peculiar genetic features , such as the Turkish population , are still absent in publically available datasets.
However , post-hoc analyses indicated that reduced recollective processing was confined to poor-performing older adults.
However , postmigration losses of emotional , instrumental , and financial support do not account for the gap in depression between migrants and nonmigrants.
However , potential meaningful clinical gait parameters beyond speed have received little attention in frailty research.
However , power is greatly reduced for β estimates smaller than ±0.10 , such as those for variants at the TERC locus.
However , PP were more episodic , engaged a higher state of autonoetic consciousness and mental visual images were clearer and more numerous than FP.
However , pQCT revealed distinct abnormalities in both novel measures of bone structural geometry and skeletal strength at the radius compared with healthy controls.
However , precise attentional mechanisms gating encoding and maintenance in VSTM and across development remain less well understood.
However , predictors might be more or less powerful depending on the characteristics of the MCI sample.
However , preincubation with compound C , an AMPK inhibitor , prevented GN-mediated effects.
However , preoperative right ventricular ( RV ) echocardiography parameters that predict adverse events in these patients are poorly understood.
However , prescribers should be aware of such potential drug-related side effects.
However , prescribing behaviour is likely to depend on changing clinical guidelines.
However , presentation time was also manipulated for letter matching.
However , present methods to measure telomere length are fraught with shortcomings that limit their use.
However , pretreatment of young or old DCs with LPS or probiotics failed to enhance the proliferation of T-cells derived from older donors.
However , pretreatment with curcumin ( @date@ μmol / L ) dose-dependently attenuated all above-mentioned pathological changes in appoptosin-transfected SH-SY5Y cells.
However , pretreatment with curcumin ( @date@ μmol / L ) dose-dependently attenuated all above-mentioned pathological changes in appoptosin-transfected SH-SY5Y cells.
However , pre-treatment with SIRT1 inhibitor ( EX527 , or sirtinol ) did not affect the levels of MITF and tyrosinase.
However , previous measurements have been complex , operator-dependent or invasive.
However , previous research does not highlight examples of long-term care innovations that scaled-up.
However , previous studies indicate that micronutrient fortification can alter food sensory attributes and , potentially , consumer liking.
However , previous studies on grey matter abnormalities in relatives have produced inconsistent results.
However , previous work has only examined CBF while supine , although an upright posture common to daily living may lead to further reductions.
However , prior in vivo depletion of macrophages in aged mice resulted in lesser cytokine levels , increased survival , and decreased liver histopathology.
However , prior knowledge was strongly related to error correction for both younger and older adults.
However , prior studies suggest that screening mammography patterns are dependent on age rather than health status or mortality risk of women.
However , problems such as mosaicism and low mutagenesis efficiency continue to pose challenges to clinical application of such approaches.
However , processes and circumstances associated with ageing can lead to risk of social isolation and / or increased alcohol consumption.
However , processing speed and IIV may influence these effects , even among high-functioning adults.
However , programs appeared to attract different types of volunteers and different degrees of volunteer commitment.
However , progress in treating human ailments , especially age-related conditions such as cancer and Alzheimer's disease , moves at a relative snail's pace.
However , promoter hypermethylation increased significantly with age ( p < 0.001 using regression analysis ) and this was gender independent.
However , proper end-of-life care needs to be ensured in hospitals , should this be the most appropriate end-of-life care setting.
However , proper perioperative management is essential to achieving the desired effects.
However , prospective longitudinal data from middle-aged populations are scarce.
However , proteasome inhibition may not necessarily be the initiating event.
However , protein chains can adopt a multitude of conformational states , and their biologically active conformation is often only marginally stable.
However , protein effects are not significant for short-term changes in bone density.
However , protein-enriched supplements did not increase effects of WB-EMS alone.
However , protein expression within different thymic subsets , stromal and / or lymphoid , has not been characterized due a lack of specific reagents.
However , proteins function by interacting with other proteins , and this is exactly what biological networks ( BNs ) model.
However , protein supplementation did not enhance resistance exercise-induced increases in myofiber hypertrophy , satellite cell content , or myonuclear addition in young healthy men.
However , protonation of nitrite under acidic conditions facilitates the formation of s-nitrosothiols.
However , providing both hints caused a significant increase in solution rates.
However , providing frailty assessments can be difficult because many factors must be taken into account.
However , providing n-3 FA can restore levels of brain DHA in E4 animals and in other models of n-3 FA deficiency.
However , PRT carries some risk , particularly when participants are older adults with a certain degree of muscle weakness.
However , PSC-derived cells exhibit fetal-like characteristics and remain immature in a dish.
However , psychological well-being was lower for those with more negative family interactions.
However , psychometrics have never been assessed.
However , publications on blood telomere length ( BTL ) and cancer are inconsistent.
However , published accuracy studies on AHRS are mostly limited to a single task measured on a limited number of segments and participants.
However , p-values do not reach the preset Bonferroni correction of the p-values.
However , pyramidal signs ( @number@ patients ) and mild cognitive problems ( @number@ patients ) were occasionally present.
However , QCT / FEA predictions of stiffness and strength showed sex was insignificant ( p ≥ @number@ ) .
However , Qe has extremely low water solubility , which is a major challenge in drug absorption.
However , quality of parameter maps may be affected by artifacts of motion , susceptibility , and eddy current-induced distortions.
However , quercetin decreased the viability of human embryonic NSCs in culture , accompanied by decreased Akt phosphorylation and increased cleavage of caspase-3 and PARP.
However , R² and ETA² < @number@ as well as discrete standardized beta coefficients indicated reduced effect.
However , randomized controlled trials of testosterone supplementation have been underpowered for the outcome of cardiovascular events.
However , randomized controlled trials of vitamin K1 or K2 supplementation in white populations did not increase bone mineral density at major skeletal sites.
However , rapamycin also exhibits a number of harmful adverse effects.
However , rapid action of dietary vitamin D3 on the postprandial glucose profile has not been analyzed.
However , rapid social changes are reshaping Taiwanese family values and structures.
However , rates of arterial recanalization vary widely , depending upon the clot burden , its location , and stroke subtype.
However , ratings for Choice and Select samples were unaffected ( > @number@ ) when brand was disclosed.
However , ratio did not demonstrate a significant change between the two groups.
However , raw Heshouwu has been noted to be better than processed Heshouwu regarding anti-aging effects.
However , RCTs that manipulate free thyroxine levels within the normal range are lacking and would be challenging to perform.
However , readmission was high.
However , recent advances suggest that if senescent tumour cells are not cleared from the tumours , they may promote tumour progression and metastasis.
However , recent animal studies have unraveled a type of permanent cochlear damage , without an elevation of hearing thresholds.
However , recent clinical trials in mild-to-moderately affected patients have been inconclusive regarding the real efficacy of DHA in halting this disease.
However , recent data do identify MIF as a key player in the immune privilege of hair follicles.
However recent data have challenged this opinion.
However , recent discoveries point toward a critical role for adipocytes in endocrine function as well as immune regulation.
However , recent epidemiological and retrospective studies suggest that it might be a disease predominantly of older women.
However , recent epidemiologic , genetic and molecular studies support a major role for oxidative stress in both dry AMD and XFS development.
However , recent evidence suggests that men who take exogenous T may face increased risk of stroke , heart attack , and prostate tumorigenesis.
However , recent evidence suggests that the quality of muscle tissue may be more functionally relevant than its quantity.
However , recent findings have revealed an alternate side to the story , the HIF-independent tumour suppressor functions of pVHL.
However , recent findings raise the possibility that SIRT3 may regulate some mitochondrial functions indirectly , rather than by direct deacetylation of specific mitochondrial substrates.
However , recent findings show that PI increases linearly throughout the lifespan due to morphological changes of the pelvis.
However , recent findings suggest that the assembly of disease proteins into tightly ordered aggregates can significantly delay proteotoxic onset.
However , recent investigations have also suggested that free radicals can act as modulators of several signaling pathways such as those related to sirtuins.
However , recently E2 was shown to be synthesized by muscle and its systemic and intramuscular hormone levels are unequal.
However , recently it has been discovered that certain sirtuins with weak deacetylase activity also hydrolyze novel acyl lysine modifications.
However , recent molecular biology discoveries have revealed that microRNAs ( miRNAs ) are potential sensors of aging and cellular senescence.
However , recent molecular network analysis reveals that the same list of genes with different interactions may perform different functions.
However , recent reports indicate that VASH1 is expressed not only in ECs but also in other cell types including haematopoietic cells.
However , recent scientific studies have advanced the notion of oxidative stress and inflammation as the two major risk factors underlying aging and age-related diseases.
However , recent studies demonstrated that indices of intraindividual variability ( IIV ) yielded unique information complementing TSS.
However , recent studies from specific regions in South Africa have found conflicting evidence.
However , recent studies have demonstrated that resistance training lead also to substantial increases in mitochondrial function in skeletal muscle.
However , recent studies have documented measurable oxidation in remelted HXLPE retrievals.
However , recent studies have revealed a molecular circuit that directly links DNA damage to compromised mitochondrial biogenesis and function via p53.
However , recent studies have revealed that vitamin E has dual effects on the aging process.
However , recent studies have suggested that epigenetic mechanisms may also influence the onset of ageing-associated diseases and longevity.
However , recent studies in a variety of organisms have identified conceptual and practical limitations to this theory.
However , recent studies suggest higher pulse pressure is instead associated with smaller aortic diameter.
However , recent trends have yet to be been reported.
However , recent work has shown that nuclear factor erythroid-2-related factor-2 ( Nrf2 ) confers protection against oxidative stress.
However , records did not suggest systematic dementia management.
However , recurrent reactions and hypopigmentation at the injection sites were noted.
However , reduced collagen production induced by short-term unloading may only marginally affect tendon mechanical properties in elderly individuals.
However , reductions in anterior and posterior cortical regions were exacerbated in older adults with SBM compared with typical peers.
However , regression analysis did not show age to be an independent predictor for A-LOC.
However , regression-based normative formulae that simultaneously correct for all demographic variables may be more sensitive for detecting late life cognitive decline.
However , related statistical methods for testing SNP-SNP interactions are underdeveloped.
However , relationships between inflammatory biomarkers , chronic viral infections , clinical factors , and behavioral factors remain poorly understood.
However , relationships between longitudinal changes in brain function , brain structure , and cognitive performance in older adults are less well understood.
However , relationships between LRP5 polymorphisms and micro- and macro architectural bone characteristics assessed by pQCT have not been studied.
However , relative age-related disparities persisted.
However , relative incidence of stroke between the genders appears to normalize at advanced ages.
However , relatively few older people with UI seek treatment.
However , relatively few population-level data are available for rare haematologic malignancies.
However , relatively little is known about factors that help some spouses become resilient.
However , relatively little is known about how non-health factors affect HRQOL.
However , relatively little is known about the attitudes of older widowers to new romantic relationships and remarriage or repartnering.
However , relative refractory period had a smaller coefficient of repeatability in relation to the changes previously described during ischemia.
However , relative to the baseline the effect is larger for men ( @percent@ vs. @percent@ , respectively ) .
However , remarkably little is known on which epigenetic changes are required to allow the firing of replication origins.
However , remarriage did not increase grandchild production because it compromised the success of motherless first-marriage offspring.
However , replication has been low.
However , reports about the effects of ATO on MSCs are limited.
However , reports of declines have not been a consistent finding across the sensory systems.
However , reports testing for an association of schizophrenia with the resulting proline elevation have been conflicting.
However , research among older adults being clinically evaluated for cognitive concerns , a defining feature of MCI , is lacking.
However , researchers in the social identity tradition argue that developing social group memberships can counteract the effects of isolation.
However , researches on anatomic and morphologic features of the knee in Chinese populations of both sexes have never been conducted.
However , researches on effect of ginkgo aglucone flavone to immune function are rare so far.
However , research exploring the psychosocial needs of aging women with HIV is limited.
However , research focused on obesity , aging , and Metabolic Syndrome has demonstrated merits of increased dietary protein and reduced amounts of carbohydrates.
However , research into this association has predominantly focused on negative factors such as depression.
However , research on the health status of individuals with HD is limited.
However , research to date has not elucidated the factors that mediate the relationship between low literacy and poor health outcomes.
However , research typically tests memory only once , shortly after encoding.
However , resources are limited and health-care budgets are finite.
However , results from animal studies are often inconsistent.
However , results from ROC curve analyses indicated that only TMT-A and -B total time had moderate discriminative abilities.
However , results from these studies failed to replicate the age-related RM impairment observed in aging.
However , results obtained in vitro may not easily be transferred to in vivo systems.
However , results of fine-mapping studies did not implicate any specific candidate genes within this region of interest.
However , results on the effect of hormonal supplementation to treat or prevent sarcopenia are contradictory.
However , results show that a major IL-12p70 inflammatory response remains prevalent.
However , results were conflicting.
However , results were often contradictory and inconclusive.
However , resveratrol-fed mice demonstrated increases in GSK3-β phosphorylation , a @number@.8-fold increase in protein levels of transthyretin , and a @number@.2-fold increase in drebrin.
However , resveratrol has numerous other targets that could contribute to its health benefits.
However , resveratrol is insoluble in water and has stability issues.
However , reviews have yet to illustrate and compare the four methods systematically.
However , rigorous preoperative planning is necessary in order to avoid complications.
However , risk of colorectal cancer was increased if smoking was continued into higher adult age.
However , RK did not affect the inhibition of early-stage adipocyte differentiation.
However , robust conclusions cannot be drawn because of significant heterogeneity in measurements and potential risk for biases.
However , robust patients who do not present in-hospital complications may not need geriatric liaison.
However , ROS-mediated therapeutic mechanisms of MSCs still remain largely unknown.
However , rs11600875 minor allele was associated with significantly increased levels of exon-2 skipping , but only in frontal cortex.
However , rTL differences for working at least full-time were greater in women with higher stress and epinephrine levels.
However , sagittal balance has not been studied widely and most studies have focused on postmenopausal patients with osteoporosis.
However , salivary 17β-estradiol correlated with item recall in remember-cued postmenopausal women.
However , sample sizes were often limited and only few studies were able to adjust for relevant molecular features associated with CIMP.
However , sarcopenia was not associated with cardiometabolic risk or carotid intima media thickness in the present study.
However , SBGE had no effect on the expression levels of Fas , FasL or TNF-α.
However , SBP , DBP and PP did not change progressively with age.
However , scant attention has been paid to investigating the joint effect of functional limitations and organizational volunteering on mortality.
However , scant data are available for Italian EDs.
However , scarce literature has assessed the impact of microbiological air quality on the occurrence of fungal infections in this population.
However , scientific evidence defining the protective effects and mechanisms of Polygonum multiflorum against ischemic stroke is incomplete.
However , scientific evidence to support the most appropriate treatment for diabetes in the elderly is scarce.
However , scope-of-practice laws are restrictive and their modification remains a source of controversy.
However , scores were normal one year following testing.
However , Scrib has also been shown to be mislocalized to the cytoplasm in breast and prostate cancer.
However , self-affirmation moderated the effect of efficacy information.
However , self-reported cognitive failures are biased by variation in depressive symptomatology.
However , self-reported hearing difficulty is associated with experiencing unmet health care needs.
However , self-transcendence was the strongest predictor of overall personality change.
However , senescence also contributes to the decline associated to aging and the development of several diseases.
However , senescent ECs demonstrated deficient Nox4 ubiquitination , resulting in sustained expression of Nox4 and alterations in cellular redox homeostasis.
However , sensitivity and specificity of cut-off values were generally moderate.
However , sensor data often have to be manually classified and segmented before they can be processed into clinical metrics.
However , separated participants who self-reported traumatic experiences had shorter LTL.
However , sequential changes of Bifidobacterium species ranging from newborns to centenarians remain unresolved.
However , serial breast biopsy analysis in nonpregnant premenopausal women suggested relatively stable baseline levels of COX-2 expression , which persisted independent of menstrual cycling.
However , serial vital sign assessments may have increased sensitivity , especially when viewed in the context of individualized reference ranges.
However , serious medical complications remain a concern , correlating strongly with high ASA and ACE-score.
However , serious metabolic complications including bone loss and fractures are becoming common.
However , seroconversions to all four serotypes were achieved only after three doses.
However , serum T levels did not significantly differ among the groups.
However , several are supported with only limited literature findings.
However , several clinical trials with androgen replacement therapy have failed to show clinical benefit.
However , several experimental studies suggest that the direct action of glucocorticoids on tendons is detrimental.
However , several histological studies on human alcoholic chronic pancreatitis did not prove the presence of fatty pancreas in such cases.
However , several lines of evidence suggest that multiple pathologies are necessary for clinical manifestation of the disease.
However , several others proteins showed altered phosphorylation levels in AD suggesting that deregulated phosphorylation may contribute to AD pathogenesis.
However , several pathophysiological mechanisms in OSA are reversible with appropriate therapy.
However , several problems still have not been solved satisfactorily.
However , several single-predictor models showed a predictive accuracy of MCI conversion comparable to that of any multipredictor model.
However , several studies have shown that there may be a large variability in the gene expression levels of HKGs in various cell types.
However , several unanswered questions remain about the underlying mechanism ( s ) involved.
However , several unexplained discrepancies in the results weaken this literature.
However , severe and broad pleural adhesion due to the pleural interventional procedures sometimes cause serious bleeding when the patients undergo lung transplantation.
However , sex differences in the aging process have not been explored so far for these genes.
However , side effects and drug interactions are difficult to control in elderly individuals.
However , significant associations with ESR2 polymorphisms were identified.
However , significant differences between the maternal and paternal BITSEA ratings were not found among the infants of either sex.
However , similar results were obtained with the other formulae.
However , similar to other adult stem cell niches , the hematopoietic system is vulnerable to the detrimental effects of aging.
However , similar to progerin , klotho variants associated with lifespan differences may repress butyrate-mediated Wnt hyperactivation , and thus increase the risk of CRC.
However , simple and quick assays to detect such damaging agents have not been developed using human cells.
However , simulations suggest that the critical nucleus size might be on the order of @number@ chains under physiological conditions.
However , simultaneous bilateral femoral neck fractures among the geriatric population ( those aged ≥65 years ) are rarely reported in the literature.
However since CBP is a co-factor for multiple transcription factors , BH-3 only proteins other than Bim could also contribute to this apoptosis pathway.
However , since its discovery , RSV has not infrequently been detected in adults.
However , since the latter evolve corticofugally in time , this suggests that NP-related NFT do so as well.
However , single-nephron GFR remains relatively constant with healthy aging as does glomerular volume.
However , Sirt1 gain of function does not increase mitochondrial function , which raises a question about the central role of Sirt1 in SRT1720 action.
However , sitting time was only positively associated with incident diabetes in obese women.
However , size invariance was found for observers of 13-17 years and for adults in this task.
However , sleep duration decreases with age and this may affect the relationship of sleep duration with mortality.
However , slightly higher body mass index and waist circumference were the only metabolic differences.
However , smiling can potentially change the way a person is perceived along different facial dimensions , including perceived age.
However , smokers with normal spirometry but low KCO had lower ASMMI values compared to those with normal KCO.
However , smoking cessation courses may not be appropriate for this age group : none of the recruits agreed to take a cessation course.
However , social and / or physical environment interventions could be more effective if they were rural-grounded , not urban-translated.
However , social disparities were evident with lower rehabilitation utilization among blacks and those with less education.
However , social exchange theory suggests that social interaction entails both rewards and costs.
However , social or behavioral causes for this trend cannot be excluded.
However , social support and knowledge about complications of untreated hypertension are the most important independent determinants of adherence to pharmacological treatment.
However , socioeconomic disparities may affect survival for some patient populations.
However , so far CR significantly increased average lifespan only in the Wisconsin , but not in the NIA monkey study.
However , so far the effect of age on sleep microstructure has been mostly addressed in small samples.
However , so far the processes underlying increased RT variability are poorly understood.
However , so far there is no direct evidence that this is true for older adults.
However , so far there is no evidence directly linking the FTO gene to functional cognitive processes.
However , so far , there is no evidence whether sodium currents also presented the developmental changes in postnatal human atrial cells.
However , somatic mtDNA mutations have historically been difficult to study because of technical limitations in accurately quantifying rare mtDNA mutations.
However , some behavioral modifications related to abstinence of binge eating following a fasting period are crucial in maintaining the desired favorable outcomes.
However , some cognitively normal older individuals harbor neural injury similar to patients with AD , without concurrent Aβ burden.
However , some degree of stasis dermatitis is generally common in aged individuals.
However , some factors were not related to adherence and agreement-perceptions were inaccurate overall , potentially contributing to the poor accuracy of adherence-predictions.
However , some felt constrained by slow recuperation and overwhelmed by unexpected comorbidities , medication-related side effects , and health decline.
However , some generalizations can be made.
However , some individuals arrive to advanced ages without any major health problems , referred to as healthy aging.
However , some initial correlations were not significant after controlling for a wide range of demographic and psychosocial risk factors thought to influence loneliness.
However , some investigations have reported intact binding with aging , and specific deficits arising only in Alzheimer's disease.
However , some of its parts need reassessment and focusing.
However , some of the associations were age-dependent.
However , some of the lesions were suspected to progress to the invasive stage , into the papillary dermis after a long period of time.
However , some of these conditions occur at increased rates , with increasing severity , or pose special problems in older persons with HIV infection.
However , some progestogens can increase cardiovascular risks.
However , some recent findings support the hypothesis that the long-term effects of diet also involve epigenetic mechanisms.
However , some risks like a gradual loss of privacy should not be underestimated.
However , some toxicities are concerned in the elderly such as arterial thromboembolism associated with the use of bevacizumab and cardiotoxicity with trastuzumab.
However , some treatment modalities seem promising even in symptomatic patients with large haematomas.
However , some variants retained functioning similar to the wild type.
However , some visible minorities are less likely than their majority counterparts to seek and receive services and treatment for dementia.
However , source recall performance was poor at both ages , suggesting that this ability continues to develop beyond middle childhood.
However , sparse research has been conducted on potential psychosocial benefits.
However , spatial working memory integrity seems to affect strategic learning decline even after controlling for aging.
However , specialized care or rehabilitation programs for DSL are scarce.
However , specific differences between the @number@ cell types could be observed.
However , specific outcome measures to assess social health and social participation are needed.
However , specific studies on physical activity in PD are scarce , and results are conflicting.
However , speech language understanding and higher brain function were less affected by aging.
However , spontaneous extracellular ROS production increased continuously with age.
However , spousal support does not have to be unanimously positive.
However , sputum fractionation itself had a relatively minor effect on the levels of these proteins.
However , SS-31 treatment reduced markers of parietal epithelial cell activation ( Collagen IV , pERK1 / 2 , and α-smooth muscle actin ) .
However , staff-to-resident communication becomes more important over time.
However , stage I-III young patients had a similar disease-free survival period as the older patients.
However , standard conditions remain to be defined.
However , standardization of practices seems to contribute to institutional exclusion and foster nonrecognition.
However , statistical methods for modeling and comparing groups of networks have lagged behind.
However , ST had no effect on memory and attention performance.
However , strategies to encourage elderly compliance may prevent falling.
However , strategies to treat aging in humans , such as hormone replacement , have mostly failed to achieve their desired response.
However , stratified analysis showed that AD group had higher B2B2 genotype frequency than control group in Asian populations with APOE4 + in Taq1B.
However , strength values of auto-polymerized and dual-cured specimens did not generally correlate.
However , stroke outcome is also dependent on the brain's capacity to restore cellular functions impaired by ischemia , and this capacity declines with age.
However , stroke resulting from carotid stenosis is expected to increase with the aging population.
However , strong induction of autophagy accompanied by robust upregulation of Beclin1 could cause autophagic cell death , thereby proving to be detrimental.
However , structural studies in this field are still missing.
However , structural topological configuration of the human brain during this specific development period is not well understood.
However , studies addressing this tack at the molecular , cellular and behavioral level are limited.
However , studies based on mutual body odor aversion are rather inconclusive.
However , studies comparing LDP with ODP in elderly patients are limited.
However , studies comparing LLR with ORL in elderly patients are limited.
However , studies comparing monolinguals and bilinguals on such metrics have produced inconsistent results complicated by confounding variables and methodological concerns.
However , studies demonstrating systemic transport of nitrogen oxide species and release of NO prompt the question of whether IPC could also exert nonlocal effects.
However , studies evaluating the gender-specific association between muscularity and mortality among older adults are lacking.
However , studies examining the effects of T replacement on cognition , emotion and fine motor function in older men have not provided consistent results.
However , studies exploring the relation between microRNAs dysregulation in AD and synaptic plasticity are scarce despite the well-known involvement of microRNAs in synaptic plasticity.
However , studies have long focused on pre- or post-menopausal women , and its presence in men has been underestimated.
However , studies have not yet explored the causal relationship between stress and telomere length , or the molecular mechanisms underlying that relationship.
However , studies have shown that the environment could modulate certain lifestyle habits which , in turn , can influence cognition.
However , studies investigating the consequence of pickiness on subsequent changes in diet intake and weight are limited.
However , studies investigating the effects of providing autonomy support during the learning process of older adults remain scarce.
However , studies of multimorbidity patterns over long time periods are scarce.
However , studies of the prognostic implications of DAPs remain scarce.
However , studies on cholesterol measured in late-life and cognitive function have been inconsistent.
However , studies reporting on AF in patients with CHD are scarce.
However , studies to date have been relatively small and have produced heterogeneous results.
However , studies to investigate the rehabilitation intervention for lumbar decompression surgery during hospitalization are scarce.
However , studies using stable Ca isotopes have found that dietary protein increases Ca absorption without increasing bone resorption.
However , studies were limited by their cross-sectional design , reliance on blood-based measures of Aβ , and potential sample bias.
However , studies with a large population of patients and a long-term follow-up should be conducted to validate our findings.
However , studies with larger sample sizes are needed to confirm its safety.
However , study partners ' appraisals of functional and behavioral symptoms were linked to increased distress even in this very mildly affected community cohort.
However , study-specific measures indicated that many participants had positive gains.
However , subgroup analysis showed problem-solving as a potential effective approach for positively affecting emotional status.
However , subgroup analysis suggested an increased risk of sICH in patients taking both SSRI and OAC.
However , subjective contours were less precisely interpolated and their interpolation was affected more by support ratio than was the case for partial occlusion.
However , subsequent analyses reported conflict results to replicate the role of RAB39B mutations in patients with early-onset Parkinsonism.
However , substantial variability characterizes age-related effects on the brain so that some older individuals evince clear neurocognitive declines whereas others are spared.
However , subtype determination is not possible during lifetime.
However , successful insertion may not be sufficient to achieve specific modification of function.
However , successful oxime treatment in soman poisoning is limited due to rapid aging of phosphylated acetylcholinesterase ( AChE ) .
However , successful treatment can substantially improve quality of life.
However , such an approach has not been supported by evidence in the literature.
However , such an approach is limited by a narrow therapeutic focus that fails to address the progressive and multimodal nature of OA.
However , such a pleiotrophic effect has not been fully studied in a new statin ( pitavastatin ) .
However , such a shift towards successful treatment has not been achieved for osteoarthritis.
However , such choices may not always be obvious.
However , such compensatory effects decline during ageing.
However , such evidence comes from population studies carried out mainly in the USA.
However , such intake of supplements is often compromised by the lack of adherence among the elderly.
However , such models have limitations and underlying assumptions.
However , such proteins did still not crystallize and allowed only partial peak assignment in NMR.
However , such studies on the other parts of this medicinally important plant are still quest to be investigate.
However , such substitutes are still in early stages of development and will therefore probably not alleviate this problem within the next few years.
However , suicide ideation is not always present when an older adult is depressed and is sometimes present when an older adult is not depressed.
However , survival of the nth1Δ rad16Δ double mutant was significantly reduced after entry into the stationary phase.
However , surviving partnerships tend to be emotionally and physically satisfying and are marked by relatively frequent sex.
However , survivors were independently associated with a significantly lower FS ( B = @number@ ) .
However , sustainability remains a major issue that could limit the appeal of RT as a therapeutic approach without well-defined dosing requirements to maintain gains.
However , sustainability requires continuous review to enable improvement and must be integrated into routine business.
However , sustained AChE inhibition failed to exert long-term effect on PS1.
However , systematic analysis and understanding of the actual differences in OATP expression between liver tissue and commonly used cellular systems is lacking.
However , systematic differences may exist between referred populations.
However , systematic investigations of differences in judgments of passage of time between young and elderly people are very rare and contradictory.
However , T4 and fT4 partially mediated the protective effect of PFOS on BDT total scores.
However , targeted screening of individuals at high risk could increase its cost effectiveness.
However , tau has also been found in the extracellular medium.
However , tau pathology is also intimately associated with neurodegeneration and amyloid pathology.
However , TB is assumed to have a dose-dependent toxic effect on the corneal endothelium.
However , team sport training motivated the participants more by intrinsic factors than resistance training.
However , technological innovations may also have unintended consequences.
However , telephone interview data were unable to reliably distinguish MCI from normal cognition.
However , telomere length was significantly inversely correlated with lifetime depression exposure , even after controlling for age ( p < 0.05 ) .
However , temporal order memory for fixed sequences is comparable between older adults and young adults when temporal interference is minimized.
However , TE showed larger improvements in handgrip than HE.
However , testicular growth started at a normal age and attained macro-orchid size in all evaluable adults.
However , testing the durability of the implants in vivo is time-consuming and expensive.
However , test measures did not discriminate between FTLD-tau and FTLD-ubiquitin.
However , TGF-β1 has also been reported to decrease expression of Klotho protein.
However , thalamic connectivity of some other cortical regions ( right sensorimotor , left inferior temporal ) showed a decrease with age.
However , that the levels of effective postsynaptic depolarization for LTD and LTP inductions are concomitantly shifted in opposite directions put constraints on them.
However , that was not statistically different from the liner or the Rocatec group without ultrasonic cleaning ( p < @number@ ) .
However , the 1-year prevalence of use , dose , and duration of use of other PPMs remain high and potentially inadequate.
However , the ABC-6 was more sensitive in detecting subtle differences in balance confidence in older adults with diabetes without diagnosed DPN than the ABC-16.
However , the ability of community providers to administer screens is not known.
However , the ability to make step adjustments may be compromised when the walker's attentional capacity is limited.
However , the ability to predict the degree of improvement of functional capacity after comprehensive examination of elderly inpatients is still lacking.
However , the absolute number of years with cognitive impairment remained relatively constant with age.
However , the accuracy of measurement by BIA is questionable.
However , the accurate mechanisms , especially at the cellular level , for CR-induced aging delay are still under intense investigation.
However , the actual factors responsible and the extent of their contribution to individual health status are not known.
However , the addition of alum adjuvant to a split or subunit influenza vaccine has induced only marginal improvements.
However , the adequate volume of strength training volume adequate to promote improvements , mainly during the initial period of training , still remains controversial.
However , the adjustments can also be explicit and intentional.
However , the administration of remifentanil can prevent intubation-induced QTc interval prolongation.
However , the administration of these drugs carries the risk of inducing injection site reaction ( ISR ) .
However , the advent of glycoproteomics has produced major strides in glycoprotein identification and glycosylation site mapping.
However , the aged care sector is still in the early stages of adopting ICT.
However , the ageing process starts much earlier.
However , the age-related alterations of the topological organization of the brain connectome in aMCI patients remained largely unknown.
However , the age-related changes in grip force-generating capacity are not clear.
However , the age-related effect of knee joint angle on the torque-angular velocity relationship and power production of this functionally important muscle group is unknown.
However the alternative explanation by an increasing proclivity to search for meaning has not been ruled out to date.
However , the amount of collagen extracted was limited to the contact surface.
However , the amount of time needed to gather EEG data means that most laboratory studies use relatively small sample sizes.
However , the anatomy of this region is not fully understood.
However , the anesthesia was injected on areas of scar tissue.
However , the anticancer activity of CA on human colorectal cancer cells and the underlying mechanisms remain to be elucidated.
However , the apparent increase was largely related to the relative decreasing rate of H. pylori infection , which profoundly inhibited gastric acid secretion.
However , the application of these measures in clinical practice requires more detailed examination in older individuals.
However , the application of this method in the elderly has its own peculiarities because of age-related changes of organism.
However , the approach to studying and understanding these effects differs between children and adults.
However , the approach to treatment is similar , regardless of the age of the patient.
However , the ASA24 interface was not intuitive for some participants , particularly young children and older adults.
However , the assessment of donor diabetes was imprecise and based on historical data only.
However , the assessment of these geriatric conditions is rarely incorporated into clinical trials and treatment guidelines.
However , the association between anticholinergic drug use and functional status is still poorly investigated , particularly among subjects with initial cognitive impairment.
However the association between changes in nutritional status and relevant functional outcomes remains under-researched.
However , the association between community social capital and life satisfaction was statistically non-significant among the high family capital group.
However , the association between heart rate and endothelium-dependent vasodilation remains highly controversial.
However , the association between insulin and bone mass in adults remains unclear.
However , the association between LAN exposure and atherosclerosis has never been explored in humans.
However , the association between leptin and GFR has never been demonstrated.
However , the association between other characteristics of social networks and obesity is unclear.
However , the association between preference for solitude ( PfS ) , SI , and SH is unknown.
However , the association between purpose in life and objective physical function has not been examined.
However , the association between RASSF1A promoter methylation and lung cancer risk remains unclear.
However , the association between RIT2 polymorphism and PD risk has not been positively replicated in Asian population yet.
However , the association between serum C1q level and muscle mass and strength remains unclear in humans.
However , the association between the autonomic nervous activity and the SDPTG indices has not yet been elucidated.
However , the association between the MBL2 profile and the HBV mutation and quasispecies complexity has not yet been reported.
However , the association of the APOE ε4 allele before and after stroke is not well understood.
However , the associations between adverse childhood experiences and depressive symptoms were not explained by social support and coping.
However , the associations between age and subfield volumes across the entire lifespan are unknown.
However , the associations of carbonyl stress with aging process and biochemical alteration of erythrocyte are still poorly understood.
However , the associations of foot posture and foot function to specific foot disorders at the population level remain poorly understood.
However , the associations of its metabolites , dihydrotestosterone ( DHT ) and estradiol ( E2 ) , with mortality are poorly defined.
However , the associations of specific FOXO3A polymorphisms with longevity remain inconclusive.
However , the association was not significant after adjusting for covariates.
However , the asymmetry indexes observed suggest that the elderly are exposed to repetitive asymmetric loading during locomotion.
However , the Atg7 deficient cells additionally showed drastic DNA damage- and cell cycle arrest signaling.
However , the authors found no differences between the speech motor coordinative patterns of young and elderly adults.
However , the availability of effective disease-modifying drugs for AD is currently limited.
However , the availability of ICU beds is limited.
However , the average number of cancer hospitalizations for radiologists showed an annual decline from @number@ to @number@
However , the average rate for diabetes fell @percent@ for women , @percent@ for men.
However , the B2B2 genotype of Taq1B was associated with increased risk of AD in the Asian populations with APOE4 + .
However , the basic biology underlying chronic wounds and the influence of age-associated changes on wound healing are poorly understood.
However , the basic mechanisms underlying exercise-brain connections are not well understood.
However , the beneficial effect for the female sex is lost upon menopause , a time corresponding to the onset of fall in estrogen levels.
However , the beneficial effects of hDSPCs on aged skin remain to be elucidated.
However , the benefits of treatment of normal elderly subjects with GH appear to be marginal and counterbalanced by worrisome side effects.
However , the bidirectional association between tooth loss and severe cognitive impairment cannot be ruled out.
However , the biochemical and mechanistic events leading to band @number@ cluster formation have yet to be fully defined.
However , the biological activity of resveratrol is limited by its photosensitivity and metabolic instability.
However , the biological and clinical significance of this age-associated epigenetic drift is unclear.
However , the biological effects of major pregnancy complications on the cellular properties of hUC-MSCs remain to be studied.
However , the biological mechanisms through which this link occurs require more study.
However , the biological mechanisms underlying these associations remain unclear.
However , the biological relevance of paracrine GLP-1 for β cell function remains unclear.
However , the biological significance of the variants on ANRIL promoter and exons is still unknown.
However , the biological underpinnings of frailty remain unclear and the interaction with HF is complex.
However , the biomolecular mechanisms underlying the photorejuvenation of IPL treatment remain largely unknown.
However , the blood-oxygenation level-dependent ( BOLD ) signal is a composite of both neural and vascular activity.
However , the bone and vascular impact of lifetime GHD on the aging process remains unknown.
However , the brain dysfunction that leads some individuals to develop delirium in response to stressors is unclear.
However , the brain structural development associated with TV viewing has never been investigated.
However , the brunt of the degenerative process involves the striatum.
However , the BTS trunk angle and STS ratio were more linked to functional capacities.
However , the cancer signature comprised only @number@ age-hypomethylated loci , none on the X chromosome , and with no overlap with the normal signature.
However , the cardiac transplantation remains epidemiologically insignificant because of donor pool limitations.
However , the causal relationship between low levels of lamin B1 and cellular senescence and its relevance in vivo remain unclear.
However , the cause for the particularly high incidence of injury in this age group is not well understood.
However , the causes of inflammaging and the origin of the associated inflammatory mediators have remained enigmatic.
However , the causes of these alterations on NK cells in old donors are not fully understood.
However , the CCN1-treated MPCs did express a senescence marker ( SA-βgal ) .
However , the cell fate plasticity of endogenous pericytes in vivo remains unclear.
However , the cells on which the CB1Rs are expressed and their function in islets have not been firmly established.
However , the cellular and molecular basis of this phenotype remains to be clarified.
However , the cellular and molecular changes underlying this predisposition are not entirely understood.
However , the cellular mechanisms eliciting these responses remain unknown.
However , the cellular roles of AIRAPL in this process are not known.
However , the Center for Disease Control and Prevention's Advisory Committee for Immunization Practices recommends the vaccine in individuals aged 60-years or older.
However , the change in CAVI that occurs following long-term CPAP treatment for OSA remains unclear.
However , the change in lens absorption did not exceed the magnitude of the change in response amplitude and latency.
However , the change in serum hormones over time was associated with cognitive decline.
However , the change of @number@ hmC level in hepatocellular carcinoma ( HCC ) and association with clinical outcome were not well defined.
However , the characteristics of the cortical network in Mild Cognitive Impairment ( MCI ) are still largely unexplored.
However , the characteristics of the equol isomers on dermal gene / protein expression and human skin percutaneous absorption remain unknown.
However , the characteristics of the skin friction coefficient in different genders and age groups have not yet been well established.
However , the circumstances associated with DPC without family are unclear.
However , the clinical benefit seems to be limited to patients with moderate to severe depression.
However , the clinical features of the disease will change with a decrease in the number of persons with Helicobacter pylori infection.
However , the clinical relevance and respective underlying pathogenesis , varies greatly among the different NF types.
However , the clinical significance of MBs in subjects without cerebrovascular disease is still unclear.
However , the clinical significance of this genetic alteration is yet to be determined.
However , the clinical success has been limited by many factors.
However , the clinical usefulness of myocardial TG measurements in Japanese subjects has not been fully investigated.
However , the cochlear orientation does not significantly change during postnatal development.
However , the cognitive correlates of these measures , particularly in the context of clinical diagnoses like major depression , are still poorly understood.
However , the cognitive skills addressed by the MMSE require an education and language skills.
However , the combined effect of both protein supplementation and exercise has not been investigated among sarcopenic elderly in the Asian population.
However , the combined effects of these compounds on skin aging are yet to be investigated.
However , the common factors associated with hair graying and systemic diseases have not been elucidated.
However , the comparative value of these parameters is unknown and no studies have evaluated the clinical optimal cut-off values of DSCSA and SCCSA.
However , the complete CaRFAX model has not been tested in nonclinical populations.
However , the complexity of resultant enriched samples is often still high , suggesting that further separation of enriched phosphopeptides is required.
However , the component of body composition that is associated with adiponectin concentrations in older adults remains unclear.
However , the compositions of these herb mixtures are complex and their mechanisms are often unknown.
However , the concept of inducing in vivo synthetic lethal RNAi responses has not yet been addressed.
However , the concept that asthma can affect older individuals has been largely denied in the past.
However , the condition had an effect on age differences in happiness recognition : Age-related deficits were only evident in the context-poor condition.
However the conformational pattern of ligand receptor binding is unclear.
However , the connection between aging and development is not clear.
However , the consumption of whole-fat dairy products may be associated with cognitive decline in the elderly.
However , the consumption of whole-fat dairy products may be associated with cognitive decline in the elderly.
However , the continued presence of autophagy is essential for cell survival and dysfunctional autophagy is thought to speed up the progression of neurodegeneration.
However , the contribution of apoptosis and autophagic cell death to p53-dependent cell death is unclear.
However the contribution of commonly observed life-long sub-optimal intakes of trace elements to the development and severity of age-related chronic diseases is less appreciated.
However , the contribution of hTRG to sensory neuropathy in HIV has not been carefully evaluated.
However , the contribution of IL-17 to age-related prostate tumorigenesis remains unclear.
However , the contribution of LINE1 to genomic variability during normal aging and in age-related neurodegenerative diseases is poorly understood.
However , the contribution of these non-glycolytic functions in tumor progression remains poorly defined.
However , the contribution of this marker to long-term outcome has not been assessed in patients with chronic coronary heart disease.
However , the co-occurrence of HS-Aging pathology and AD neuropathology ( AD-NP ) did not indicate any pattern of correlation between the two pathologies.
However , the correlation coefficients became weak.
However , the cortex is only one of several targets of anesthesia.
However , the cost-effectiveness of the CKD-EPI creatinine-cystatin C equation for clinical use should be considered.
However , the cross-seeding effects of other protein aggregates on Aβ aggregation pathways are not completely clear.
However , the current evidence came predominantly from Caucasians and the role of genomic ancestry has not been investigated.
However , the current methods are not sufficiently flexible to address all of these constraints.
However , the current paradigms for IBD management might not be directly translatable to older patients with IBD.
However , the current therapeutic approach to the prevention of minimal trauma fracture is unilateral and focuses solely on bone.
However , the cutoff point of the MNA should be modulated for this population.
However , the decision concerning a ( radio ) chemotherapy should be made individually in each patient.
However , the decline in their purchasing power limits the demand for oral health care services.
However , the decrease in hospitalization rates slowed over the last half of the study , settling at @percent@ in the last @number@ study years.
However , the deep layer showed no significant change with aging.
However , the defined procedures for the measurement of arterial stiffness are time consuming and not practical in daily practice.
However , the defined role of lipid rafts in the autophagic flux is still unknown.
However , the definition of cognitive leisure activities often has been inconsistent and diverse.
However , the degradation of the exposed collagen was decelerated in the presence of chlorhexidine.
However , the degree of the increase was much higher in LB25 than in N2.
However , the degree to which HIV influences age-related innate immune changes , and the biomarkers which best reflect them , remains unclear.
However , the detailed mapping of frontal connections remains incomplete , albeit crucial to an increased understanding of these cognitive functions.
However , the detailed mechanism by which GN inhibits hepatic steatosis remains to be elucidated.
However , the detailed mechanism of PPARα / γ's role in photoageing has not yet been elucidated.
However , the detailed mechanism of PPARα / γ's role in skin aging has not yet been elucidated.
However , the detailed molecular pathomechanism implying E3 ubiquitin ligases in cellular functions in multifactorial disease conditions are not well understood.
However , the detailed molecular pathomechanism of MGRN1 in cellular functions and diseases is not well known.
However , the details of Aβ effects on the other AD pathologies remain poorly understood.
However , the details of clinical symptoms of osteoporotic vertebral fractures with intravertebral cleft are poorly understood.
However , the details of the cognitive dysfunction that occur in late-life SSD are still unknown.
However , the developmental course of many key brain regions supporting face preferential processing in the human brain remains undefined.
However , the developmental nature of this phenomenon remains largely unexplored.
However , the development and pattern of disease-related cortical changes have not yet been demonstrated in PD with qMRI methods.
However , the development of new medicines for elderly people will face a number of challenges that are not seen for other patient populations.
However , the development of resistance to cisplatin is a major obstacle in clinical therapy.
However , the development until early adulthood is not well understood and , in particular , not the individual tracking pattern.
However , the diagnostic protocol for syncope is difficult to apply to patients with dementia.
However , the difference between elderly and young adults did not vary over conditions.
However , the difference between groups was not statistically significant.
However , the difference in blood pressure ( BP ) based on clinic and ambulatory monitoring in CKD patients of different ages is not known.
However , the differences between the pediatric and adult cases are not such that development of pediatric sized valves is untenable.
However , the differential genetic associations of 3DGI and SA with GCA are still unclear.
However , the diploidy rate was significantly increased with patient's age.
However , the direct role of mtDNA methylation on gene expression remains elusive.
However , the direct targets that mediate their effects on longevity remain unclear.
However , the dissection of these experiments of Nature has also led to major immunological advances.
However , the distribution and localization of Gal-3 and AGEs has never been performed in human chronic skin wound tissue.
However , the diverse , multiple and dynamic nature of demand for long-term care complicates the movement towards demand-based care provision.
However , the dose and the intensity of PA producing the most benefit are still debated.
However , the durability of responses to primary chemotherapy is significantly shorter than in young patients.
However , the duration of in vivo studies and the huge number of possible variations in vaccination protocols have discouraged their optimization.
However , the dynamic response profile and kinetics of cerebrovascular function have not been determined to date.
However , the effectiveness of these alternative approaches is still a topic of debate.
However , the effectiveness of these treatments are limited or controversial and they do not modify disease progression.
However , the effect of age on default mode subnetworks has not been documented well , and age-related changes in many resting-state networks remain debatable.
However , the effect of age on FFR has not been well-studied.
However , the effect of auditory attention on MOC inhibition in children was not robust and was significantly lower compared to that observed for adults.
However , the effect of BA on embryo implantation remains unknown.
However , the effect of chromatin structure on BER protein recruitment to DNA damage sites in living cells is poorly understood.
However , the effect of chronic aspirin on the incidence of AF has not been evaluated in a prospective cohort followed for an extended period.
However , the effect of endocrine therapies on serum DKK-1 and sclerostin levels in patients with primary breast cancer remains elusive.
However , the effect of forehead cooling on coronary blood flow velocity ( CBV ) is not well understood.
However , the effect of lifelong exercise dose on metabolic and hemodynamic response during exercise has not been previously examined.
However , the effect of MGO on the cell systems responsible for repairing or degrading damaged proteins is still unclear.
However , the effect of mitogenic growth factor on cellular senescence is so far largely unknown.
However , the effect of NSAID intake , and thus blockade of PGE ( @number@ ) production , on the tendon tissue adaptation is unknown.
However , the effect of omega-3 fatty acids on human protein metabolism is unknown.
However , the effect of Perilla frutescens on skin has not been characterized well.
However , the effect of pharmacological treatment is not satisfying.
However , the effect of resveratrol on axonal degeneration is still controversial.
However , the effect of senescence on maceration has not been fully elucidated.
However , the effect of testosterone on brain function is not well understood.
However , the effect of the coexistence of multiple cardiovascular diseases on the prognosis of hospitalized patients with CHF remains unclear.
However , the effect of the spinal component ageing on the fracture risk of the cortical shell remains poorly understood.
However , the effect of transient and persistent geriatric AKI on short-term mortality is unclear.
However , the effect of widowhood on depressive symptoms and psychological difficulties did not differ significantly across time points.
However , the effect of WMH on statistical analysis of DTI estimates has not been thoroughly studied.
However , the effect size of gender was smaller than that of age , and it was not significant for gait regularity.
However , the effects of aging and task demands on the functional integration of neural networks contributing to speech production abilities remain largely unexplored.
However , the effects of aging on cardiac extracellular matrix ( ECM ) components in individuals free of cardiovascular disease are incompletely understood.
However , the effects of aging on memory reconsolidation and its neural substrate remain largely unknown , and an animal model is lacking.
However , the effects of altered inflammatory response on the metabolic status of tissues or organs are not well documented.
However , the effects of cell-free extract of ATSCs ( ATSC-Ex ) containing secretome on wound healing process have not been investigated.
However , the effects of ginseng are not fully explained by ginsenosides.
However , the effects of levodopa only appear contributory and are surpassed by age and lower folate levels.
However , the effects of miR-34a on the processes of DNA damage and repair are not entirely understood.
However , the effects of MT-training on neural mechanisms beyond MT-related functions are not known.
However , the effects of nutrient \ "top-ups \ " in humans , and particularly older adults where deficits exist , have not been explored.
However , the effects of phlorizin against ultraviolet B ( UVB ) irradiation and its molecular mechanism are still unknown.
However , the effects of progesterone administration on sleep are not well characterized.
However , the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown.
However , the effects of tenuigenin on Parkinson's disease remain unclear.
However , the effects of these products on balance recovery mechanisms following an externally induced perturbation have yet to be quantified.
However , the effects on the PCS and MCS were small and likely not clinically relevant.
However , the efficacy and precise mechanism of Nitraria alkaloids remain largely unknown.
However , the efficacy of current protective vaccines is highly variable , particularly in aging populations.
However , the efficacy of influenza vaccines that are licensed for use in the elderly is relatively low ( 17-53% ) .
However , the efficacy of testosterone replacement in this setting remains unclear.
However , the efficiency of human iPS cell generation is extremely low and therefore elucidating the mechanisms underlying cellular reprogramming is of prime importance.
However , the elderly as the young subjects produced shorter latencies in the gap condition than in the overlap condition.
However , the elderly group did not show significant changes.
However , the emotion-focused orientation did not affect older adults ' emotional memory.
However , the epigenetic mechanism that regulates microglia polarization remains elusive.
However , the estimated recruitment rate among eligible patients was @percent@.
However , the etiology of OA is multifactorial involving genetic , mechanical and environmental factors.
However , the events which lead to the induction of chronoinflammaging in AD are yet to be clarified.
However , the evidence also suggests a complexity of metabolic influences , both systemically and within muscle , which has not been elucidated to date.
However , the evidence base concerning which factors predict better outcomes and who receives the greatest benefit in reablement is lacking.
However , the evidence base for the use of such aids is very limited , and there is some evidence that they are used inappropriately.
However , the evidence for their effectiveness is contradictory and weakened by reliance on single-group designs and / or small samples.
However , the evidence from in vivo investigations in healthy people is mixed , and there are no quantitative estimates of the association strength.
However , the evidence is still inconclusive , mostly based on CVD mortality and studies with single 25 ( OH ) D measurements.
However , the evidence of the impact of pharmacists ' interventions on health outcomes , quality of life or cost effectiveness of care is mixed.
However , the evidence on the adverse effects of iron deficiency remains controversial.
However , the evidence remains weak.
However , the evolutionary growth of these parameters may be nonmonotonic and may fluctuate significantly.
However , the exact contribution of mTOR signaling and uterine aging to endometrial pathologies is currently unclear.
However , the exact effects and molecular mechanisms of Beclin-1-mediated autophagy in osteosarcoma are still unknown up to now.
However , the exact form of DMN-HC alterations in aging and concomitant memory deficits is largely unknown.
However , the exact mechanism is unknown.
However , the exact mechanism of the effect of memantine in Alzheimer's disease patients is poorly understood.
However , the exact mechanisms driving insulin resistance have not been completely elucidated.
However , the exact molecular function of p53 remains to be clearly defined.
However , the exact molecular mechanisms linking these PD risk factors to neuronal dysfunction are still unclear.
However , the exact neurofunctional maps underlying emotional facial processing are not well defined.
However , the exact role of these characteristics in the disablement process remains uncertain.
However , the experience of MCC has not been explored with a broad sample of community-living older adults , family caregivers and healthcare providers.
However , the expression levels of IGFBP2 in insulin resistance disorders have not been evaluated.
However , the expression of many individual gene families was much more strongly correlated after injury in mice and humans.
However , the expression of MMP-1 mRNA was reduced by bakuchiol and E2.
However , the extensive functional effects of those drugs remain essentially unexplored.
However , the extensive quantitative data on this phenomenon have never been systematically reviewed.
However , the extent of agreement in nondemented older adults remains unclear.
However , the extent of the mechanistic overlap between RM and CR remains incompletely understood.
However , the extent to which CPs and CN interact during earlier stages of disease progression remains unknown.
However , the extent to which factors of arousal and contextual information influence the positivity bias in older adults remains to be determined.
However , the extent to which planning occurs within prison settings is unknown.
However , the extent to which prospective memory failures may influence quality of life in typically aging older adults is not well understood.
However , the extent to which SBP fluctuations affect BP classification as well as the potential effect of age are unknown.
However , the extent to which they are related to health care expenditures has not been examined.
However , the extent to which this difficulty is attributable to impaired eye-movement control is uncertain.
However , the factors contributing to these differences are not well understood.
However , the factors linking muscle strength with mobility disability are unknown.
However , the factors that are associated with frailty are poorly understood.
However , the factors that govern the decline of HA synthesis during the course of actinic aging are largely unknown.
However , the factor structure using the abbreviated version was supported.
However , the FAS-670 GG genotype may increase the risk of AD in the younger population ( age , ≤65 years ) .
However , the feasibility and safety of SDD in more complex patients and lesions has received limited study.
However , the feasibility and utility of ultrasound examination have been poorly investigated.
However , the feasibility of using EFAT2 needs to be explored and larger studies are required to confirm its reliability.
However , the few investigations quantifying cortical thickness have yielded inconsistent results , probably due to variable ages and / or small sample sizes.
However , the field must adapt to remain relevant.
However , the field remains conflicted over the relative importance of each process , while key spatiotemporal features of BOLD response remain unexplained.
However , the findings did not support the hypothesis that klotho mediates the relation of 25 ( OH ) D with physical performance.
However , the findings in the general adult population are unclear.
However , the findings may be limited by self selection and additional research is needed to confirm and extend the current findings.
However , the findings provided evidence of an additional effect of substance abuse on further risk of falls in older adults with dementia.
However , the findings suggest several other possible benefits , which may be available only to online communities.
However , the fractional optic produces a localized area of epidermal necrosis which results in a significant clinical and a delayed thermal effect.
However , the frequency of causative mutations in EOAD could be variable depending on studies.
However , the frontal positivity was again associated with poorer performance.
However , the frontal-subcortical network was not associated with change in executive functioning.
However , the full potential of stem cell science will only be reached if all possible avenues can be explored and on a worldwide scale.
However , the functional relevance of the structural connectivity between left and right mid-dlPFC is yet unknown.
However , the functional role of CEBPD in astrocytes remains largely unclear.
However , the functional role of TH phosphorylation at the Ser-31 site ( THSer ( P ) -31 ) remains unclear.
However , the functional roles of these bone marrow-derived macrophages ( BMDMs ) in aging are unclear.
However , the functional significance of these progeria-associated blebs remains unknown.
However , the function and phenotype of these Aβ plaque-associated microglia are not well understood.
However , the function of AR target genes has not been fully elucidated.
However , the function of Gadd45a in hematopoietic stem cells ( HSCs ) remains unknown.
However , the function of GDF11 in the bone is barely understood.
However , the function of klotho in eyes including retina is still poorly understood.
However , the function of LRG in the brain during aging and neurodegenerative diseases has not been investigated.
However , the function of MSCs is known to decline with age , a process that is called senescence.
However , the functions and contributions of lncRNAs remain largely unknown.
However , the fungal culture examination of the BAL fluid revealed mucormycetes , which were later identified as Cunninghamella bertholletiae by PCR and DNA sequencing.
However , the general molecular mechanisms by which this occurs remain unclear.
However , the genetic frequency , neuropathology and downstream consequences of riboflavin transporter mutations are unclear.
However , the genetic loci identified so far account for only a small fraction of the overall heritability.
However , the genetic mechanisms underlying adult neurogenesis in AD have been underexplored.
However , the genetic underpinnings of complex relational processing have not been investigated.
However , the genotypic effects in genetic and in vitro approaches were divergent.
However , the geometric and component changes of aging hearts because of chronic hypertension remain unknown.
However , the global and regional brain %SUV values between AD patients and age matched controls are not different from each other.
However , the group-reference benefit is limited , emerging as smaller than the benefit from self-referencing.
However , the hallmark of almost all closely related species is a differing chromosome complement and therefore chromosomal rearrangements seem to be crucial for speciation.
However , the heart has intrinsic oxygen demands that must be met to maintain effective contractility.
However , the heterogeneity of subjects identified as having MCI and variability in interventions and outcomes continued to limit generalizability.
However , the high cost of purified protein can be a limitation for many laboratories around the world.
However , the high drop-out rate suggests that flexibility is required in community-based healthy ageing programs.
However , the histomorphological features and clinical significance of the EM in the cervical spine based on operative findings have never been reported.
However , the homo-specific activity ( activity / enzyme protein ) of TH is increased.
However , the HR for males failed significance in the validation group.
However , the HRV is superior to annual health examinations for predicting the longevity of very elderly residents of long-term care facilities is unknown.
However , the HTA is the solution of rising national burden of medical costs.
However , the ideal dose of exercise for improving longevity is uncertain.
However , the idea that EID ≥ @number@ % bodyweight ( BW ) impairs endurance performance is well ingrained.
However , the identities of specific factors mediating memory-enhancing effects of young blood and their mechanisms of action are enigmatic.
However , the identity of specific forms of ROS that promote longevity remains unclear.
However , the identity of the Nox enzyme ( s ) involved in prostate carcinogenesis remains largely unknown.
However , the impact of aging on the development of CRS has been long overlooked.
However , the impact of ApoE4 on amyloid burden and glucose metabolism across different clinical AD syndromes is not well understood.
However , the impact of DON leadership across all measured areas of DON jurisdiction has not been tested using comprehensive domains of quality deficiencies.
However , the impact of DT training on the incidence of falls in the elderly remains unclear.
However , the impact of dual tasking on kinetic and kinematic gait parameters is unclear because these vary with gait speed.
However , the impact of experienced stress on the human aging process has remained an under-researched possibility.
However , the impact of high sodium intake , an important risk factor of age-related diseases , on telomere shortening remains unknown.
However , the impact of non-malignant factors on CRP levels in patients with cancer remains unknown.
However , the impact of Nordic walking training on sarcopenia-related parameters in women with low bone mass remains unknown.
However , the impact of OBT-A in clinical practice remains to be defined.
However , the impact of preceding weight change on blood glycemia levels in late-life is less well understood.
However , the impact of several variables was moderated by age.
However , the impact of sex on pulse pressure , an index of vascular aging , in unindustrialized populations has not been addressed.
However , the impact of shortened telomeres and telomerase dysfunction on the ability of lung cells to respond to significant challenge is still largely unknown.
However , the impact of the mode of exercise on cardiovascular ( CV ) risk factors in type @number@ diabetes is unclear.
However , the impact of these factors on the genome-wide DNA methylation pattern in human adipose tissue remains unknown.
However , the impact of this intervention on survival has not yet been studied.
However , the implantation and the long stay of CVC are associated with many complications.
However , the implications of these findings are unclear.
However , the importance of miRNAs in regulating OS in the context of aging and cellular senescence is largely unknown.
However , the improvement also may reflect some brain changes that are beneficial for the course of schizophrenia along with neuroplasticity of aging.
However , the improvement in clinical risk prediction was found to be small.
However ; the improvement score decreased with time.
However , the inappropriate use of psychoactive drugs in patients with dementia in nursing homes is still prevalent.
However , the incidence of intraoperative blood transfusion was higher in the cAPT group ( P = @number@ ) .
However , the incidence of thin reticulated collagen and the number of dermal papillae were statistically higher on the sun-protected posterior aspect of ear lobule.
However , the incidence rate reached a plateau during the disease course.
However , the inclusion of AD biomarkers in clinical criteria poses socioethical challenges.
However , the increased content of melanin is associated with myriad dyschromias including melasma and postinflammatory hyperpigmentation ( PIH ) .
However , the increased fear-like behavior exhibited by the 60-day-old HFB rats may elicit performance deficits in conditioned and unconditioned fear tests.
However , the increased risk of mortality in urban areas was not significant after taking into account health behaviors and baseline health status.
However , the induction of CD200R expression in MDMs under various conditions is impaired in the old groups , especially in PD patients.
However , the influence of age on the genetic factors determining IGF-1 levels is not clear.
However , the influence of antipsychotics ( and dopamine ) on ERP measures are poorly understood and medication confounding remains a possibility.
However , the influence of healthy adult aging on multisensory integration of emotional stimuli remains poorly explored.
However , the influence of iron overload on bone health in the general population is uncertain.
However , the influence of other types of discrimination on health has been understudied.
However , the influence of reactivation on subsequent memories was reduced in older adults.
However , the influence of subjective loneliness among elderly persons is poorly documented.
However , the influence of the stimulus frequency at the tissue level has remained elusive.
However , the inherent limitations of mobile devices make them less effective in computation- or data-intensive tasks such as medical monitoring.
However , the in-hospital mortality remains relatively higher in female than in male patients ( @percent@ vs @percent@ in @number@ ) .
However , the injured elderly had a significantly higher oxidative burst at time period @number@ than the NIE controls.
However , the intake of vitamin B6 and Zn from dietary supplements exceeded the recommended daily intake for almost a quarter of the supplement users.
However , the intensity of staining for endostatin in dermal blood vessels was increased during aging.
However , the interaction between MB and anticholinergic cognitive burden ( AB ) on neuropsychological performance is unknown.
However the interaction explained only @percent@ of the observed variance.
However , the interaction showed that cultural differences were reduced once health status , gender and age were taken into account.
However , the interactions indicate that this association lessened in strength for both the objective and subjective cognitive outcome measures as social network resources increased.
However , the interactions of multi-targets targeted by effective ingredients of kidney-tonifying Chinese herbal medicines are unknown.
However , the intraspecific rate of aging was shown to vary over of a wide range depending on living conditions.
However , the intrinsic circadian rhythmicity in this species remains to be fully characterized.
However , the intrinsic link between Golgi impairment and tau pathology is missing.
However , the invasive nature of blood draws severely limits sample collection , particularly with children.
However , the in vitro lifespan and senescence mechanisms of human NPCs remain unclear.
However , the involvement of MA in skin-pigmentation has not been reported.
However , the involvement of neuronal loss to the epileptogenic process has yet to be fully determined.
However , their activity may be restricted by multiple inhibitory influences in situ.
However , their aggregate effect on risk is uncertain.
However , their antigen specificity especially in humans is largely unknown.
However , their application among elderly people rendered very different results.
However , their association with bone turnover markers in native Chinese women remains unknown.
However , their broader pathophysiology remains ill-understood.
However , their clinical use is limited by the lack of validated reference intervals.
However , their combined impact on mortality in adults ≥65 years with heart failure ( HF ) is not well understood.
However , their desire remained strong to emulate the media promoted image of bronzed youth being popular individuals.
However , their different efficacy and safety have not been systematically compared.
However , their discriminatory power for the differential diagnosis of dementia is suboptimal.
However , their durability in liquids has been questioned.
However , their exact mechanism of formation remains unclear.
However , their functional interplay has been unclear.
However , their major biochemical and physiological function does not appear to depend on their redox ( reduction and oxidation ) activity.
However , their mechanism of action is poorly understood.
However , their optimal use ( in terms of combination , sequence , and duration ) remains unknown.
However , their overall cold-adaptive traits have disappeared since they began to wear wetsuits and research has waned since the 1980s.
However , their possible role in pancreatic β-cells remains unknown.
However , their regenerative capacity decreases with aging , limiting efficacy in old patients.
However , their relationship in residents of long-stay institutions remains unclear.
However , their reported prevalence varies between studies and their co-occurrence is unknown.
However , their risk stratification abilities in the broad community remain uncertain.
However , their role in age-related cardiac remodeling and heart failure is unknown.
However , their role in clinical practice is undefined.
However , their roles in glioma remain unclear.
However , their short lifespan and serious cell-intrinsic and cell-extrinsic alterations restrict the application and interpretation of carcinogenesis protocols.
However , their underlying pathomechanisms and regulation of RAN translation remain unknown.
However , the issue of whether glycolytic metabolism influences metastasis in HCC remains unclear.
However , the key constituents in RJ responsible for improvement of cognitive function are unknown.
However , the key question is whether men are expected to respond differently to osteoporosis therapies than women.
However , the key upstream pathological mediators and the molecular cascade leading to epigenetic Klotho suppression are not exclusively established.
However the kinase responsible for this phosphorylation or the biological significance of this finding is not yet established.
However , the knowledge about the exact mechanisms of AOPs is still incomplete.
However , the KSR2-rs7973260 A allele exhibited pleiotropic effects on some metabolic phenotypes in Chinese elders.
However , the lack of appropriate measures available to neuropsychologists poses a challenge for the direct assessment of these skills.
However , the lack of consensus concerning the willingness-to-pay per quitter impedes drawing firm conclusions.
However , the lack of evidence should not be considered , as absence of effect and practitioners should continue to be creative in developing solutions.
However , the lack of standard criteria for measuring speed of aging makes such claims highly questionable.
However , the large number of skills that humans acquire during ontogeny militates against plasticity as a perpetual process of volume growth.
However , the latter finds no support from recent genetic studies.
However , the level of these proteins has not been examined during ageing or in young individuals with short smoking histories.
However , the levels of expression were not identical ; NRXN1 increased with age and NRXN2 levels were consistently higher than for NRXN3.
However , the limited life span significantly restricts their usefulness.
However , the link between elevated AOPP levels and elderly mortality risk has not yet been investigated.
However , the link between elevated GA / HbA1c levels and the risk of cognitive impairment in nondiabetic individuals is unclear.
However , the link between metabolic rate and longevity is imperfect.
However , the link between the microbiome and frailty is as yet mostly unexplored.
However , the link between TRF1 and inhibition of telomerase elongation of telomeres remains elusive because TRF1 has no direct effect on telomerase activity.
However , the links between conversation enjoyment and empathy were stronger for older adults.
However , the link with cognitive impairment remains unclear.
However , the literature is mostly deficient of evidence provided by Italian Mediterranean islands that more closely adhered to the originally described lifestyles.
However , the literature is scarce regarding PE in patients above the age of @number@ years.
However , the literature on the specific mechanisms whereby ACE affects suicidality in later life has not been well identified.
However , the local flap failed and the fistula persisted.
However , the locomotor behavior is more conservative compared to the young ones , leading to disadvantages in the reactive adaptation during disturbed walking.
However , the long-lived individuals maintained values similar to those in adults.
However , the long term effect of reducing the PVR by bosentan treatment on exercise capacity in Fontan patients is still unknown.
However , the long-term effect of WOC on zest for work is poorly understood.
However , the long-term effects on WMI remained unclear.
However , the long treatment duration is a major drawback.
However , the low aqueous solubility rendered them undesirable drug candidates.
However , the low EF group only showed a beneficial effect under low levels of effort.
However , the lower outcome scores documented in older patients do not take in consideration the decreasing requirements of an aging joint.
However , the magnitude of CBF response above baseline was comparable between groups.
However , the magnitude of effects was significantly influenced by the amount of postural sway demonstrated by individuals prior to Geri-Fit training.
However , the magnitude of the decrease in serum T was strikingly small ( < 10% ) .
However , the magnitude of the relationship between compassion and volunteering is fairly modest.
However , the magnitude of this role is usually modest.
However , the main compounds currently used to treat early AD , acetylcholinesterase inhibitors ( AChEIs ) , are unsatisfactory in efficacy and safety.
However the main function of EGT and the reasons for its active accumulation in the body remain obscure.
However , the main phosphorylation sites and functional importance of the phosphorylation of WRN has remained unclear.
However , the major causes of the age-dependent decline of islet function are still disputed.
However the majority of DS cases are born to young couples.
However , the majority of ' low ' tapes were also found to be ' high ' in PC.
However , the majority of participants highlighted issues unique to dementia care that warranted additional consideration.
However , the majority of patients with severe MR do not undergo surgery because of high perceived perioperative risk.
However , the majority of preclinical mouse tumor models assessing potential efficacy and toxicities of therapeutics use young mice.
However , the majority of studies showed a high risk of specific forms of bias.
However , the major mechanism underlying the super p53-dependent apoptosis remains unclear.
However , the major risk factors include hypertension , diabetes , pain , and polypharmacy.
However , the malfunctions of these mechanisms damage the genetic apparatus , accelerate the aging and bring to a number of illnesses.
However , the management of post-operative period should be more careful in fragile patients.
However , the manner of the H-reflex modulation during dynamic muscle movements in relation to ageing is less stated in the literature.
However , the material is susceptible to aging or hydrothermal degradation and to chipping of the feldspathic veneer.
However , the maximum percentage of inhibition achieved against hydrogen peroxide was @percent@.
However , the meaning of ' place ' for adults experiencing homelessness has been largely overlooked.
However , the mechanism by which DM increases the risk of AD has not been elucidated.
However , the mechanism by which ER stress affects immunity remains poorly understood.
However , the mechanism by which mitochondrial quality is regulated remains unclear.
However , the mechanism by which USP14 regulates inflammation remains unclear.
However , the mechanism directly involved in neuroprotection is still poorly understood.
However , the mechanism for this inhibition is not clear.
However , the mechanism of its contribution remains to be established.
However , the mechanism responsible for the up-regulation of its expression is still unclear.
However , the mechanisms behind these changes remain unclear.
However , the mechanisms by how aging affects the recruitment of trunk muscles during walking remain unclear.
However , the mechanisms by which aging impacts immunity to influenza lung infection remain unclear.
However , the mechanisms by which DAC induces antiproliferation via these processes and how they are interconnected remain unclear.
However , the mechanisms by which perceptions of parental bonding translate into vulnerability are unclear and remain sparsely investigated in healthy populations.
However , the mechanisms by which PON1 exerts these effects remain to be elucidated.
However , the mechanisms by which TDP-43 mutations induce neurodegeneration remain unclear at present.
However , the mechanisms by which these processes are linked remain largely elusive.
However , the mechanisms by which this occurs are not fully understood.
However , the mechanism ( s ) for increased susceptibility in this subpopulation are not well understood.
However , the mechanisms for their beneficial effects have not yet been definitely established.
However , the mechanisms governing this important sex-specific difference are not well understood.
However , the mechanisms involved have only been partially discovered.
However , the mechanisms linking abnormal lipoprotein levels to breast cancer progression , especially metastasis , remain unclear.
However , the mechanisms linking cardiovascular dysfunction with the core behavioral features of mood disorder remain poorly understood.
However , the mechanisms linking them are not clear.
However , the mechanisms of the anti-cancer activity of A. cepa Linn are not fully elucidated in human cancer cells.
However , the mechanisms of this fundamental process are poorly understood so far.
However , the mechanisms that control cellular IGF2R abundance are poorly known.
However , the mechanisms that influence the frequency of somatic mtDNA mutations are poorly understood.
However , the mechanisms that regulate survival or death of CD8 ( + ) CD28 ( - ) T cells remain incompletely understood.
However , the mechanisms that shape the composition and function of the human memory T-cell pool remain incompletely understood.
However , the mechanisms that underlie HFD pathophysiology have yet to be elucidated fully.
However , the mechanisms underlying age-related changes in hormone efficacy have not been determined.
However , the mechanisms underlying cellular damage and senescence and accelerated aging in HGPS are incompletely understood.
However , the mechanisms underlying increased AHO resistance are poorly understood.
However , the mechanisms underlying pathological alterations in the brain transcriptome are incompletely understood.
However , the mechanisms underlying synaptic degeneration in Alzheimer's disease are not well known.
However , the mechanisms underlying the age-dependent accrual of Treg remain unclear.
However , the mechanisms underlying this process remain unclear.
However , the mechanisms underlying TNF-α-induced cPLA2 expression in human lung epithelial cells ( HPAEpiCs ) were not completely understood.
However , the mechanisms which are critical in determining the direction of age effects remain poorly delineated.
However , the mechanism underlying autophagy associated with ovarian carcinoma remains elusive , the precise role of autophagy in ovarian carcinoma also remains undetermined.
However , the mechanism underlying MHY908-mediated amelioration of renal inflammation with insulin resistance during aging remains unknown.
However , the mechanism underlying these effects of CR is still not clear.
However , the mechanistic relationship between age-related meniscal degeneration and osteoarthritis ( OA ) development is not yet fully understood.
However , the medial temporal lobes were more severely affected in typical AD and FTLD compared to atypical AD.
However , the median ECT course duration in repeated DTM appeared longer.
However , the mere absence of symptoms does not necessarily guarantee experiences of well-being.
However , the method can be adapted for telomere length measurements in other cells whose telomere lengths are within its detection boundaries.
However , the methods used to evaluate these consequences are often discussed.
However , the MFR device showed better improvement at @number@ weeks.
However , the mitochondrial genome is essential for normal integrity of the mitochondrial electron transfer system ( or respiratory chain ) .
However the mitochondrial population is quite heterogeneous , and can form small individual organelles or extended reticula throughout muscle.
However , the moderating role of APOE on the effects of a physical activity intervention on cognitive performance has not been examined.
However , the modest increased odds of persistent pelvic girdle pain among these users could be a result of unmeasured confounding.
However , the molecular and biochemical mechanisms of MG neurotoxicity are not completely understood.
However , the molecular and cellular mechanisms of relaxin in regulating both myogenic cell differentiation and muscle healing process are still unclear.
However , the molecular basis for its biological function remains unclear , in part due to the lack of efficient enzymatic activity in vitro.
However , the molecular basis of immune dys-regulation and the source of inflammatory markers remain unclear.
However , the molecular events occurring during brain aging are extremely complex and still largely unknown.
However , the molecular events related to satellite cell dysfunction during aging are not completely understood.
However , the molecular links between proangiogenic signals and downstream gene expression remain unclear.
However , the molecular mechanism of ART's effects on S. japonicum remains unclear.
However , the molecular mechanism of osteoblast differentiation by curcumin has not yet been reported.
However , the molecular mechanisms and factors controlling TERRA levels are still largely unknown.
How-ever , the molecular mechanisms and their causal relationships are largely unknown.
However , the molecular mechanisms associated with genome instability remain unclear.
However , the molecular mechanisms by which DRAM1 regulates apoptosis are not clearly defined.
However , the molecular mechanisms by which HCMV establishes and maintains latency and reactivates remain poorly understood.
However , the molecular mechanisms controlling hMSC aging in the context of prelamin A accumulation are not completely understood.
However , the molecular mechanisms coupling ectopic fat accumulation with aging remain obscure.
However , the molecular mechanisms involved in the neuroprotective function of IGF-1 remain largely unknown.
However , the molecular mechanisms leading to this phenotype are not yet well understood.
However , the molecular mechanisms mediating tau truncation and aggregation during aging remain elusive.
However , the molecular mechanisms mediating these effects remain poorly understood.
However , the molecular mechanisms of its activity remain poorly understood and warrant further investigation.
However , the molecular mechanisms of its activity remain poorly understood and warrant further investigation.
However , the molecular mechanisms of resveratrol action in cells are not completely understood.
However , the molecular mechanisms of the mitochondrial pathology remain enigmatic.
However , the molecular mechanisms that govern loss of Lsh expression during cellular senescence have yet to be elucidated.
However , the molecular mechanisms that maintain homeostatic properties of endothelial cells along the pathways are not well understood.
However , the molecular mechanisms that underlie htt proteotoxicity have been somewhat elusive , and the muscle phenotypes have not been well studied.
However , the molecular mechanisms that underpin these differences have not been fully elucidated.
However , the molecular mechanisms underlying aging-associated proinflammation are poorly defined.
However , the molecular mechanisms underlying aging-related Ca ( 2 + ) dysregulation are not well understood.
However , the molecular mechanisms underlying CR-induced SIRT1 upregulation in mammals remain unclear.
However , the molecular mechanisms underlying the distinct roles of CLU in a variety of conditions remain unclear.
However , the molecular mechanisms underlying the effects of gangliosides shed from tumors on macrophage phenotype remain unknown.
However , the molecular mechanisms underlying the remarkable effect of a small amount of H2 remain unclear.
However , the molecular mechanism underlying Tax-induced IKK activation is controversial and not fully understood.
However , the molecular mechanism underlying the harm in phosphate overload remains unclear.
However , the molecular mechanism underlying the involvement of ZIP4 in the pathogenesis of this condition has yet to be established.
However , the molecular targets of these species are unknown.
However , the molecules and mechanisms that mediate heme transport and trafficking , and the dynamics of these processes , are poorly understood.
However , the most robust approaches to extending healthy lifespan are frequently linked with reduced energy intake or with lowering of mitochondrial activity.
However , the motivation for a specialized mechanism at telomeres is not well understood.
However , the MR / IR ratio of prostate cancer is the lowest among cancers.
However , the multivariate regression analysis indicated that performance in the six-minute walk test was the only factor associated with hypertension.
However , the mutagenic effects of aged ZnO NPs are still unexplored.
However , the myocardial uptakes of FFAs were not significantly increased in the diabetics as compared to the non-diabetics.
However , the narrow therapeutic dose-range of quercetin has been a point of concern since previous studies have demonstrated that quercetin induces cytotoxicity in vitro.
However , the national advantage remained even when all measured risk factors are statistically controlled.
However , the natural history of C-peptide decline after diagnosis can vary considerably dependent upon several variables.
However , the nature of asymptomatic HIV-associated minor neurocognitive disorder ( HAND ) remains unclear.
However , the nature of mutant SOD1-mediated motor neuron degeneration is poorly understood.
However , the nature of their associations varied.
However , the nature of their potential interactions , mainly in the brain and immune cells , and their key involvement in aging remain unclear.
However , the nature of the relationship among the very old ( > 75 years ) is unclear.
However , the necessary intense minimum training intervals compromise patient compliance , and the impaired functional status of many PAD patients limits active exercise training.
However , the neural activity evoked during VWM retrieval yielded results that helped clarify the age-related differences.
However , the neural alterations associated with these executive deficits are still not fully understood.
However , the neural and physiological mechanisms underlying this impairment are entirely unknown.
However , the neural basis for consumers ' perception of social risk remains undiscovered , and this novel study clarifies the relevant neural processes.
However , the neural mechanisms by which this occurs remain largely unknown.
However , the neural mechanisms underlying individual differences in QOL measured by questionnaire ( QOLMQ ) in young healthy subjects are unknown.
However the neural mechanisms underlying this lifespan asymmetry were previously unexplored.
However , the neural mechanisms underlying this process are still poorly understood.
However , the neural processes underlying this effect remain underexplored , especially in the context of normal aging.
However , the neuroanatomic basis of executive impairment in patients with aMCI remains unclear.
However , the neurobiological basis of ASD in adults is poorly understood.
However , the neurobiological mechanisms underlying the learning-improved memory capacity are poorly understood.
However , the neurobiology of this secreted glycoprotein remains unclear.
However , the normal values of HRM have not been widely evaluated.
However , the number of available donor HSCs is often too low for successful transplantation.
However , the number of cones remained unchanged.
However , the number of frail women was low.
However the number of overall cases has steadily increased over time due to the rise in population.
However , the number of patients that required reduced insulin dose was significantly higher in the sitagliptin group ( p = 0.01 ) .
However , the number of people receiving renal replacement therapy is still rising as a consequence of population ageing.
However , the numbers in elderly groups are small and more investigation is needed , with specific clinical trials for elderly cancer patients.
However , the numbers of M cells are reduced in aged mice.
However , the observational nature of cohort studies precludes a definitive assessment of cause and effect because residual confounding or reverse causation cannot be excluded.
However , the observations of an association between cystatin C level and inflammation stem from large cohort studies.
However , the observation that 2-AG hydrolysis blockade alters learning and memory performance , suggests that such drugs may have limited value as therapeutic agents.
However , the obtained TH01 allele frequencies were consistent with published data.
However , the odds ratios of periodontal health did not significantly differ across 5-year interval age groups.
However , the O + group's performance was comparable to the O- group on all other neurocognitive tests ( ps > @number@ ) .
However , the older adults used different muscle strategies and sequence of muscle recruitment than that reported in young adults.
However , the old men experienced greater changes in MROM ( P < @number@ ) and passive resistance ( P = @number@ @date@ ) .
However , the only data available that can be correlated directly with national component data are the size of the total population.
However , the opposite pattern has also been observed , with MCI participants showing larger PEs than controls.
However , the optimal speed to trigger osteogenesis is still under debate because the exact loading during different speeds is poorly characterized.
However , theoretical arguments and behavioral observations in populations with disordered speech indicate that different oral motor behaviors may be governed by distinct mechanisms.
However , the organelle-specific functions are not completely understood.
However , the origin and influence of demographic characteristics ( e.g. , age or sex ) on these proteins are unknown.
However , the originating signals that trigger these mechanisms remain unclear.
However , the origin of these mutations remains controversial.
However , the origins of ROS have not been fully elucidated.
However , the other chimeric H-1 viruses ( CH4 and CH5 ) expressing a partial KRV VP2 domain induced cytolysis.
However , the other four subjects never looked directly at the rail , indicating a complete reliance on peripheral vision.
However , the outcome of training was associated with a reduced QoL.
However , the overall decrease in bout length suggests increased fragmentation and disruption in sleep consolidation that may be relevant to human sleep.
However , the overall economic impact of HI is not well described.
However , the oxidative / anti-oxidative balance has not been fully characterized in NAFLD.
However , the pan-caspases inhibitor significantly blocked the SCRT-induced apoptosis , suggesting that it is a caspase-dependent pathway.
However , the particular clinical , biochemical , and functional characteristics of the osteosarcopenic ( OS ) patients remain unknown.
However , the particular mechanisms by which memory impairment occurs in LLD are currently unknown.
However , the particular nutritional status of the sarco-osteoporotic ( SOP ) patients remains unknown.
However , the particular role of ankle muscle co-contractions in the elderly during quiet standing remains unclear.
However , the pathobiology of the disease is still poorly understood and there is no effective pharmacotherapy for treating those at risk for clinical progression.
However , the pathogenic effect of GRK5 dysfunction through targeting tau hyperphosphorylation remains unclear.
However , the pathological and clinical significance of NRF2 has remained largely unknown in breast cancer patients.
However , the pathology of HD is characterized by early and dramatic destruction selectively of the striatum.
However , the pathophysiological mechanisms remain to be further elucidated.
However , the patient died following cardiac tamponade.
However , the patient's consciousness gradually deteriorated and he died on day @number@ of admission.
However , the patients showing Klotho expression in the resected specimens in p-stage I and II , may have benefited from perioperative chemotherapy.
However , the pattern of consumption was different for antianxiety and psychiatric drugs.
However , the pattern of diffusivity differences in AD and MCI implies a more complex pathology than simply Wallerian degeneration.
However , the pattern was attenuated when using 5-year mortality from baseline.
However , the pediatric BV mechanical properties are unknown.
However the penetrance of GBA mutations is low for these diseases in heterozygous carriers.
However , the perception of the quality of the program by participants and service providers has not yet been reported.
However , the persistent differences in survival across Europe suggest variations in the quality of care and availability of the new treatments.
However , the perspectives of people with dementia and their family caregivers concerning their sleep are under-researched.
However , the photo-protective effects of aaptamine have not been elucidated.
However , the physiological and pathological functions of sTREM2 remain unknown.
However , the physiological , biochemical and molecular mechanism underlying such effects remain elusive.
However , the physiological function of ABCA7 and its transport substrates remain unclear.
However , the physiological function of Casp12 presented in cancer cells is still unclear.
However , the physiological relevance of this newly discovered catalytic activity of SIRT6 remains to be determined in vivo.
However , the physiological roles and substrates of most cyclophilins remain unknown.
However , the physiologic mechanisms of alcohol effects and the reasons for individual differences in the cardiac response remain unknown.
However , the pons , an important structure of the brain , is associated with many neurodegenerative diseases and is often damaged by brain trauma.
However , the poorer comprehension performance of older individuals indicates that their slower online processing reflects inefficient processing even at these points.
However , the poor phenotype of SIRT1 null mice has thus far precluded a more definitive test.
However , the positive effects of DR on health appear to be highly conserved across the vast majority of species , including human subjects.
However , the positive influence of physical activity on the immune system has not been elucidated.
However , the positive relationship between network size and life satisfaction is consistent across countries.
However , the possible association between inflammatory parameters and sarcopenia is poorly understood.
However , the postoperative course was uneventful despite impaired lung function in all cases.
However , the postsurgical prevalence of nodal implants does not exceed @percent@ , leading to questions concerning the clinical appropriateness of any post-endoscopy surgery.
However , the potential as a tool to support exercise-based prevention activities is not well understood.
However , the potential benefit of milk on hip fracture prevention is not well established.
However , the potential disadvantages are that blue light filtering could negatively affect scotopic vision and circadian rhythms in older patients.
However , the potential endothelial cell-derived factors that mediate this effect are still unknown.
However , the potential mechanisms underlying this association remain unclear.
However , the potential molecular mechanism by which microglial Aβ uptake is regulated remains unclear.
However , the potential role of superficial white matter ( SWM ) in aging and , by extension , cognitive-aging , is less clear.
However , the potential therapeutic effect of CR on endometrial receptivity for successful embryo implantation to treat female infertility has not been fully studied.
However , the potential to form cold-induced beige adipocytes declines with age.
However , the pre- and postoperational gallbladder ejection fraction was not significantly different.
However , the precise degree of the regional decline is not yet clear.
However , the precise etiology of persistent low-grade increases in inflammation remains unclear.
However , the precise long-term carcinogenic effects of mustard gas are unclear.
However , the precise mechanism of SVBP-dependent UPS is poorly understood.
However , the precise mechanisms by which aging promotes these mitochondrial alterations and the role of the latter in aging are still not fully understood.
However , the precise mechanisms linking nuclear envelope abnormalities to lipodystrophies remain largely unknown.
However , the precise mechanisms regulating senescence are not well characterized.
However , the precise mechanisms underlying coronary spasm are unclear.
However , the precise mechanistic correlation between inflammation and AD pathogenesis remains unclear.
However , the precise molecular mechanisms involved remain unclear.
However , the precise nutritional factors involved are unknown.
However , the precise role of AMH in the process of human follicular aging has still to be determined.
However , the precise role of cordycepin on chondrocytes is not clear.
However , the precise role of microglia during the course of AD is still under discussion.
However , the precise temporal and spatial dynamics of the microglial population are unknown.
However , the preclinical prediction accuracy for low CSF Aβ42 levels , a surrogate for brain Aβ42 deposits , is not high.
However , the predictive validity of these tools is questionable.
However , the predictive value of SRH in the presence of SMC is unclear.
However , the predictive value of this assessment model was low.
However , the presence and extent of whole-brain connectivity disturbances is largely unknown in aMCI patients.
However , the presence of comorbidity did not affect racial-ethnic disparities in mental health service use.
However , the presence of intestinal food residues with densities similar to fat may reduce fat quantification accuracy.
However , the presence of untreated obstructive sleep apnea is associated with an aging-related cognitive deficit , otherwise not present in individuals without OSA.
However , the present results suggest that many individuals might not benefit from such general recommendations.
However , the prespecified subgroup analysis suggested a possible age-dependent association between ICD implantation and mortality with survival benefit seen only in the youngest patients.
However , the prevalence of supraventricular arrhythmias in unselected AMA-M2-positive patients and the impact of AMA-M2 on supraventricular arrhythmias have yet to be fully investigated.
However , the prevalence of undermet needs remained high ; @percent@ or more for both rural and urban residents.
However , the previous view of significant cholinergic cell loss during aging has been challenged.
However , the primary spine-related reason for physician office visits is pain.
However , the principal basis for the variation of human LTL has not been established , although various studies have reported heritability.
However , the probability of becoming caries-positive did not correlate with age at the baseline visit.
However , the processes underlying the refinement of language comprehension are less clear.
However , the process leading to the formation of cancer stem cells is still not clear and thus requires further research.
However , the process of taking experimental observations between model systems and human subjects can be extraordinarily frustrating.
However , the prognosis of PML is still worse in patients receiving monoclonal antibody therapy.
However , the prognostic and biological significance of RelA / p65 is equivocal in the field.
However , the prognostic significance of advanced age itself is not clear.
However , the prognostic significance of GFR might be different according to the formula used to estimate it.
However , the program now faces many challenges in terms of sustainability.
However , the progression of athletic performance over time has not been well investigated in Masters athletes.
However , the proliferation and osteogenic differentiation capacity of PDLSC decreased while donor aging.
However , the proportion of people globally who are active enough to gain these health benefits is low and decreases with age.
However , the pro-proliferative effect of NPY on old bone marrow cells was weaker than other cell groups due to lower Y5R expression.
However , the protective effect of vitamin D on motoneuron and the influence of its levels on disease course remains elusive.
However , the quality of oocytes from older females is compromised and the pregnancy rate of older women is lower.
However , the quality of the mRNA in archived FFPE samples did significantly decline with increasing sample age.
However , therapeutic attempts to target the general state of oxidative stress in clinical trials have failed to demonstrate an impact on disease progression.
However , the rates of vaccinated HCWs are still low in France.
However , the ratios were less than @number@ in the skeleton for animals that were sacrificed @number@ and @number@ d post injection.
However , the ratio was not different between the @number@ groups ( P = @number@ ) .
However , the reader should not conclude that drug-induced QTc interval prolongation is highly predictive of PVT or its TdP subtype.
However , there also may be supply-side causes.
However , there appeared to be a compensatory increase in mitochondrial mass.
However , there are a few roadblocks in the way of this promising agent regarding its translation from the bench to the bedside.
However , there are also remarkable similarities across employers and employees.
However , there are also studies showing a negative influence of the EEG on MRI data quality.
However , there are a number of indications that AGEs have protective effects as well.
However , there are a number of resources to support this activity in relation to training , communication support and Medicare item funding.
However , there are certain pitfalls that need to be considered.
However , there are changes that occur within the HSC pool during aging.
However , there are cohorts of patients that remain symptomatic despite use of all nonoperative measures that eventually require surgical intervention.
However , there are considerable variations between Asian countries because of great disparity in socioeconomic status.
However , there are differences in the results depending on the parameter used to define OA.
However , there are few data on citrulline action on immune function in aged populations.
However , there are few data on the structural abnormalities of Achilles tendons in asymptomatic diabetic patients.
However , there are few published and validated bleeding risk schema available for AF patients.
However , there are few studies examining the effects of blue-light irradiation on oral tissue.
However , there are few studies of umbilical cord extracts.
However , there are few studies using psychophysiological methods published that describe the effects of krill oil on brain function.
However , there are few validated outcome measures that are suitable for measuring functional performance in this population.
However , there are lacks of data resources and analytical tools that can be used to examine disease associations of ARS / AIMPs.
However , there are limited data for evaluating the potential association of biomarkers with functional disability in an extremely longevous ( 95 + ) population.
However , there are limited data on influence of serum 25 ( OH ) D on risk and prognosis of malignant melanoma.
However there are limited reports regarding the effectiveness and side effects of this treatment in Asians ' skin.
However , there are little approaches to reinforce the function of circadian clock for prevention of these diseases.
However , there are little data describing the effect of fecal sample collection methods on metabolomic measures.
However , there are little data regarding the pathologic mechanisms that link vascular risk factors to the factors associated with dementia onset.
However , there are little published data on long-term pain patterns or predictors over the life course.
However , there are many day-to-day functions which require little to no control and others which even benefit from reduced control.
However , there are minimal data about the quality of POLST decisions , including whether they reflect the current preferences of well-informed patients.
However , there are no accepted pharmacologic therapies to improve impaired skeletal muscle function.
However , there are no clinical data regarding the association of Prx @number@ and prognosis in lung cancer.
However , there are no common measures or protocols to guide citizen science research at the local community setting.
However , there are no effective therapies for this pathological alteration.
However , there are no key therapeutics for OA and medical treatment is based on managing the symptoms and slowing down progression of the disease.
However , there are no previous studies that have determined whether any soft-tissue technique is effective for achieving lasting malar augmentation.
However , there are no studies of PiB binding across the lifespan in DS.
However , there are no therapies to prevent ATL development in high-risk asymptomatic carriers.
However , there are other considerations regarding the use of NOACs that must be taken into account during management of therapy.
However , there are relatively few publications on the use of mental health legislation in the detention of older adults.
However , there are reports in favor of and against cell-based therapies.
However , there are several cognitive processes ( attention , spatial and recognition memory , strategy , and associative learning ) involved in PAL.
However , there are some structures for which signal intensity changes cannot be accounted for by myelination alone.
However , there are species that may suit this role much better.
However , there are still many unanswered questions that remain.
However , the reason of the differential age effect on cognitive control efficiency is still unclear.
However , the reason that severe hypoalbuminemia has an influence on the treatment outcome of VCM remains unknown.
However , the recommendations of the preclinical AD workgroup are intended purely for research purposes.
However , there continues to be a paucity of research examining long-term health , functional activities , and participatory outcomes over their life-course.
However there continues to be room for improvement.
However , the refinement of linguistic proficiency is an ongoing process , extending well into childhood and adolescence.
However , the regions showing differences between EH and YH did not overlap between static and dynamic FC.
However , the regulatory mechanisms and functional significance of high Runx1 protein expression in resting peripheral CD4 + T cells is not well understood.
However , there has been a surge of recent research focusing on different mechanisms that underlie both physiological and pathophysiological aspects of lymphatic contractile function.
However , there has been lack of comparison with demographics of each fracture.
However , there has been limited attention to whether these living circumstances affect adherence to medicines in the ≥65 year olds.
However , there has been little investigation into the relationship between muscular strength and economy of movement during aerobic exercise in elderly subjects.
However , there has been no adequate ultrasound based method for quantifying the mechanical properties of the free human Achilles tendon.
However , there has been no genome-wide assessment of the prevalence of this phenomenon.
However , there has been no study that examined whether Japanese food in itself is effective for health maintenance.
However , there has previously been no physiological means of monitoring cholinergic activity in vivo.
However , there have been discrepancies between results reported from clinical trials and population-based studies.
However , there have been few studies examining insulin interactions with Ca ( 2 + ) regulation in aging animals.
However , there have been mixed results regarding associations between either circulating BDNF or the BDNF Val66Met polymorphism with hippocampal volume and memory in humans.
However , there have been no epidemiological studies investigating help-seeking status in individuals with PLEs and elevated risk of suicide.
However , there have been no studies on the association of intellectual development with longevity.
However , there is accumulating evidence that HSCs are themselves subject to quantitative and qualitative exhaustion.
However , there is a complexity in providing care in this context.
However , there is a concern that inhibiting BACE1 could also affect several physiological functions.
However , there is a conflicting relationship between the microvascular density and prognosis in clear-cell renal cell carcinoma ( ccRCC ) patients.
However , there is a gap in the literature concerning any mentoring programs for novice NPs.
However , there is a gap in understanding the interconnections between these pathomolecular events that prevent us from discovering therapeutic targets.
However , there is a huge scarcity of behavioral neurologists in Japan , and more of them are needed urgently.
However , there is a lack of data regarding the exercise intensities of various gardening tasks across different types of gardening and different populations.
However , there is a lack of evidence-based public health messaging to support this position.
However , there is a lack of information on the uniformity of plantar pressure patterns in the elderly.
However , there is a lack of information regarding the effect of increasing age on the level and function of ALF components in the lung.
However , there is a lack of research regarding personality disorders and suicide ideation in older adults.
However , there is a lack of specific measures and well-defined procedures for these evaluations.
However , there is a large but conflicting literature on its association with enteric infection and host nutritional status.
However , there is a lot of controversy about the role of GDF-11 and β2-MG in ageing and cognitive regulation.
However , there is also evidence that T cell immunity can be rejuvenated via activated dendritic cells and / or macrophages.
However , there is also limited evidence that these changes may only be evident in postmenopausal women and not in men.
However , there is an alternative view that androgen deficiency in the aging man may constitute a valid and underdiagnosed disorder.
However , there is a need for a framework that explains these findings in relation to masculinities.
However , there is a need for an alternative to surgical aortic valve replacement to increase the acceptance of valve implantation in an aging population.
However , there is a need for robust data concerning both the effectiveness and the cost of dispensing in-home telerehabilitation.
However , there is a need to be cautious while prescribing atypical and typical antipsychotics in older adults for long periods of time.
However , there is a paucity of data on the nature of frailty in Africa.
However , there is a paucity of data regarding the role of DC vaccines in shaping natural killer ( NK ) cell responses.
However , there is a paucity of detailed longitudinal studies to support the cross-sectional findings.
However , there is a paucity of literature characterizing foot muscle strength and morphology , and any relationship between these @number@ in older people.
However , there is a paucity of scientific investigations examining the role of older adults ' attitudes toward aging on their spouses ' psychological well-being.
However , there is a paucity of studies assessing genetic determinants of CHD in African Americans.
However , there is a significant association of the D allele with severity of WML in noncarriers of the APOE ε4 allele.
However , there is , as yet , little evidence to support claims regarding long-term benefits.
However , there is considerable intrafamilial variability.
However , there is considerable variation in how it is used and studies often provide insufficient information on the protocol followed making comparisons difficult.
However , there is controversy on the role of the stroke itself or the associated subcortical damage in post-stroke cognitive decline.
However , there is controversy regarding what constitutes low testosterone level in the aging population and at what level replacement therapy with testosterone is indicated.
However , there is currently a dearth of investigations on the impact of different educational methodologies for teaching in this area early in medical courses.
However , there is currently no consensus regarding how to assess or measure cognitive reserve.
However , there is currently no neuroimaging evidence to suggest that lifelong bilinguals can retain normal cognitive functioning in the face of age-related neurodegeneration.
However , there is currently no research establishing gap detection threshold using the N1-P2 response.
However , there is debate about independent or interactive effects of ɛ4 on Aβ-related memory decline in healthy older adults.
However , there is evidence that cognitively stimulating activities protect against the adverse effects of cognitive decline.
However , there is evidence that creatine ingestion may reverse these changes , and subsequently improve activities of daily living.
However , there is evidence that errors are not always beneficial for younger adults , nor always harmful for older adults.
However , there is evidence that PCOS can be identified from early infancy to puberty based on predisposing environmental influences.
However , there is great interindividual variability in cognitive ability among people of the same age.
However , there is growing evidence that inherited genetic variation might affect the disease prognosis and response to treatment.
However , there is growing evidence that mammalian mitochondria can also import cytosolic noncoding RNA via poorly understood processes.
However , there is growing excitement among researchers in this field that developments may yield new treatments for muscle wasting in the future.
However , there is inconsistent information with respect to selenium levels in the Alzheimer's disease brain.
However , there is insufficient information regarding their long-term outcomes.
However , there is limited data on the impact of Pilates on falls.
However , there is limited empirical evidence on the probability that overweight progresses to obesity in contemporary children.
However , there is limited evidence about how nursing homes use this publicly disseminated performance information.
However , there is limited information about the factors that influence trochanteric soft tissue thickness.
However , there is limited rigorous research on the process of spread , factors influencing spread , and models of spread.
However , there is limited understanding of the role of sleep loss on age-related differences in immune responses.
However , there is little empirical evidence about how best to undertake this involvement , particularly for specific populations of users such as vulnerable populations.
However , there is little evidence about the relationship between physical performance measures and LS.
However , there is little evidence for effective treatments.
However , there is little evidence in the behavioral literature reliably demonstrating memory deficits.
However , there is little evidence to suggest that working conditions shape observed health disparities between occupations in the years leading up to retirement.
However , there is little information about sex differences in the effect of aging on DED.
However , there is little information on physician assistant ( PA ) students ' attitudes towards older adults.
However , there is little information or evidence of this complication.
However , there is little or no evidence for a direct association between dietary nutrients and brain biomarkers of AD.
However , there is more consistent evidence for the effectiveness of ST in reducing triglyceride levels.
However , there is no accepted effective modality for correction of these disturbances ( chronotherapy , certain classes of antihypertensive drugs ) .
However , there is no clear definition of PLT so far.
However , there is no consistent evidence of an increased protection against metabolic disorders and other ailments when comparing studies in laboratory animals and humans.
However , there is no convincing evidence that the relative risk of infection with anti-tumor necrosis factor ( TNF ) -α therapy increases with age.
However , there is no direct evidence whether lead exposure has effects on bone metabolism in middle-aged male subjects.
However , there is no established intervention for obesity in older individuals.
However , there is no evaluation of the PDQ-8 in the mainland of China.
However , there is no evidence addressing the relationship between the earliest stage of CVD ( endothelial dysfunction ) and frailty.
However , there is no evidence that those hiPS-derived RPE possess specific RPE functions that fully distinguish them from other types of cells.
However , there is no information about the effectiveness of azithromycin ( AZM ) for the treatment of aspiration pneumonia.
However , there is no information on whether this group would be receptive to weight control programs.
However , there is no overall accepted definition of efficacy for aesthetic uses of botulinumtoxinA ( BoNT-A ) .
However , there is no report demonstrating experimental evidence on anti-tumor action of A. rivularis.
However , there is no scientifically established protocol available for forensic practice in such cases.
However , there is no solid prevalence data in Taiwan even with the rapid growth of the elderly population.
However , there is no study comparing minoxidil lotion with placebo for eyebrow enhancement.
However , there is now substantial theoretical and empirical support for the existence of programmed aging in mammals.
However , there is only a limited number of clinical studies supporting these claims.
However , there is potential for serious functional and aesthetic complications , including dry eyes , scleral show , and ectropion.
However , there is relatively few data evaluating the effect of age on RV diastolic filling velocities during rest or exercise in healthy subjects.
However , there is sparse epidemiologic evidence for rhinitis in the elderly population.
However , there is still a lack of information on mortality and loss of independence in extremely elderly people with a hip fracture.
However , there is still debate over whether the major impact on aging is secondary to caloric intake , protein intake or specific amino acids.
However , there is still no consensus regarding the definition and consequences of SO.
However , the relation between cognitive function and brain volume is unclear.
However , the relation between EF and adaptive ability differed by group , suggesting unique patterns of abilities in these children.
However , the relation between MnBP and HOMA was not found.
However , the relation of CB1 receptors to cognitive function in AD is at present unclear.
However , the relation remains unclear between T1DM and dementia as an aging-related disease.
However , the relationship between age of donors and the efficacy of FMT has not been examined to date.
However the relationship between Aβ burden and basal forebrain degeneration has not been extensively studied.
However , the relationship between bilingualism and cognition is complex , with costs as well as benefits to language functions.
However , the relationship between cholesterol and dementia at the population level is less clear and may vary over the lifespan.
However , the relationship between coronary spasm and atherosclerosis is not well known.
However , the relationship between cortisol output and buccal telomere length became non-significant when adjusting for medication use.
However , the relationship between CVD , amyloid burden , and cognition are largely unknown.
However , the relationship between dysfunction of the MDM2 / p53 axis and human aging remains elusive.
However , the relationship between endorphins and dopaminergic transmission has not been fully explored.
However , the relationship between FRS and Ccr was lost after controlling for age and other confounding variables.
However , the relationship between inclusion formation and an individual cell's fate has been difficult to study with conventional techniques.
However , the relationship between loss of fat and fat free mass might change in an unfavourable direction.
However , the relationship between low thyroid function and mortality in CKD patients is unclear.
However , the relationship between objectively measured SB and frailty incidence and mortality rates remains unclear and deserves further research.
However , the relationship between oxidative DNA damage and age in humans is unclear.
However , the relationship between resting heart rate and NT-proBNP is unclear.
However , the relationship between savoring and psychological well-being is stronger for people with lower resilience.
However , the relationship between sensory-processing abilities and occupational engagement among older persons in daily life is unknown.
However , the relationship between serum vitamin D and combined indices of adverse body composition is largely unknown.
However , the relationship between sex hormones and age-related alterations in older men is not clear.
However , the relationship between these two pathways and their correlation to cognitive performance needs to be scrutinized.
However , the relationship between WM and RT components is rarely examined in healthy aging.
However , the relationship is not always clear.
However , the relationship of CCL5 with vascular endothelial growth factor ( VEGF ) expression and angiogenesis in human chondrosarcoma is mostly unknown.
However , the relationship of pruritus with skin ageing and / or neuronal ageing and / or immune ageing is poorly understood.
However , the relationship remains unclear and lacks quantitative evidence in China.
However , the relationships between ACE polymorphisms and frailty are poorly understood.
However , the relationships between material composition and viscoelastic properties of bone , and their changes during aging have not yet been elucidated.
However , the relationships between several personality traits and cognitive abilities in older adults remain unclear.
However , the relationships between these entities are unclear and no quantitative meta- analysis exists.
However , the relationship was nonlinear , and β was markedly greater in patients ≥ @number@ years.
However , the relative contribution of apoptosis per se in OA pathogenesis appears complex to evaluate.
However , the relative importance of cultural preferences and economic constraints as determinants of living arrangements among the elderly depends on marital status.
However , the relative importance of these two mechanisms to drive fingertip wrinkling also remains unclear.
However , the relative prognostic value of information contained in clinical profiles of nonfrail older adults is often unclear.
However , the relevance of these peripheral measures for brain indices that are presumably more directly related to MDD pathophysiology is unknown.
However , the relevant literature is clearly deficient for most Mediterranean countries that more closely adhere to the originally described MeDi.
However , the reliability of fMRI data in longitudinal studies of older adults with aMCI is largely unexplored.
However , the reliability of these new indices and the ability of HRV to differentiate between soccer competitive levels are unknown.
However , the remaining @number@ items were statistically significant.
However , there may also be an inherent preference for temporal information.
However , there may be a role for vaginal DHEA.
However , there may be a slight risk among those surviving to an age at risk for dementia.
However , the replacement or regeneration of lost bone is not always successful and becomes more difficult the wider the bone defect.
However , the reported advantage of women as compared to men may stimulate future work on sex dimorphism of synaptic microcircuitry in the olfactory bulb.
However , the reported prevalence of resistance exercise participation among US adults aged > 50 years is very low.
However , there remains a lack of knowledge in how volunteering is impacted by other activities in the lives of older adults.
However , there remains a lack of percentile-based normative reference values for these clinically important parameters.
However , there remains limited evidence about causality from intervention studies.
However , the residue interactions between MAD2L2 and CAMP were strikingly different from those in the MAD2L2-REV3 complex.
However , the results also suggest that attention was not likely to be a factor in the age-related differences in multisensory integration.
However , the results also suggest that older adults develop greater fatigue during dynamic contractions , particularly when the decline in power is assessed.
However the results are inconsistent.
However , the results are still controversial.
However , the results have been inconclusive with some studies suggesting a preventive effect and others no effect or even an increased risk.
However , the results need to be further verified.
However , the results of different studies are often inconsistent.
However , the results of existing studies are inconsistent , possibly because of the confounding influence of variable exposure to cardiovascular risk factors.
However , the results remain controversial.
However , the results were imprecise and / or heterogeneous.
However , the revised MAL and LF-MAL both showed floor effect.
However , there was a lack of significant sex differences in BA 44 / 45 asymmetry.
However , there was a large difference in driving lane variability within the older group.
However , there was a limited association with global cognitive impairment despite a strong influence upon Pfeffer Functional Activities Questionnaire based daily function.
However , there was an age-related shift in the impetus for FNC change.
However , there was an interesting relationship between IL-6 and IL-8 concentrations , when the IL-6 was higher than IL-8.
However , there was a scarcity of studies concerning survival of colorectal cancer patients as well as its predictors.
However , there was a significant Age by Expertise interaction.
However , there was a significant decrease in macular thickness with age ( P < @number@ ) .
However , there was a significant difference in the mean grades between visits.
However , there was a significant interaction between sodium intake and obesity status ( P = 0.049 ) .
However , there was a significant reduction in the loss modulus and tanδ components ( i.e. viscous behavior ) of the hybrid layers with aging.
However , there was no association between deaths and AF ( p = @number@ ) .
However , there was no change in six of eight health status measures or anxiety level.
However , there was no correlation between APOE genotypes and serum levels of glucose or total triglycerides.
However , there was no correlation between peripheral E2 levels and any of the lipid parameters examined.
However , there was no correlation between the BBT and chair sit-and-reach test , back scratch test ( p > 0.05 ) .
However , there was no effect of sex or race on SIF420 [ kx0.5 , km0.5 ] in subjects without diabetes.
However , there was no evidence that PWS + S promoted greater overall training adaptations compared to the PWS group.
However , there was no group difference in the pinch force of any finger.
However , there was no linear correlation between the mean ALFF signal values in brain regions and clinical manifestations in MB patients.
However there was no relationship between clopidogrel responses and either PGE1 or NP responsiveness in patients with loss of function mutations.
However , there was no significant association between Candida-specific IgE antibody level and either age or birth cohort.
However , there was no significant association between plasma CRP at baseline and subsequent cognitive decline as assessed by longitudinal changes in MMSE score.
However , there was no significant association of SDF-1 with hip fractures ( p = @number@ ) .
However , there was no significant change in either isokinetic concentric or eccentric torque of the knee extensors.
However , there was no significant correlation between renal corticomedullary contrast ratio and age ( r = @number@ P = @number@ ) .
However , there was no significant difference between combined adduction-extension and quiet standing.
However , there was no significant difference between the two age groups when IgA antibody was removed.
However , there was no significant difference in AF recurrence events at follow-up comparing ALA with placebo group.
However , there was no significant difference in telomere length between different BD subtypes.
However , there was no significant difference in the control subgroups.
However , there was no significant difference of the activation voltage for peak sodium currents between two kinds of atrial myocytes.
However , there was no significant effect of their interaction.
However , there was no statistically significant difference in benefit across obesity categories.
However , there was no study in men.
However , there was substantial heterogeneity in format and application of single-item screens , and several studies were of poor methodological quality.
However , there were no age or sex differences or interaction for muscle FSR ( p > 0.05 ) .
However , there were no associations for global cognitive functioning , learning / memory , sequencing , verbal fluency , or visuoconstruction.
However , there were no changes in the expressions of epidermal differentiation maker proteins.
However , there were no differences within the group of postoperative medical treatment.
However , there were no effects of age for either MoS or LDS.
However , there were no significant correlations between sRAGE levels and patient outcome in these critically ill patients.
However , there were no significant correlations between these features of the wall vibrations and systolic / diastolic blood pressure and sex.
However , the risk allele for tremor in this gene has been associated with reduced RLS risk.
However , the risk-benefit ratio of ADT remains poorly defined and the relationship between androgen depletion and dementia is not clear.
However , the risk for injuries appears to be higher for testing than for training itself.
However , the risk of developing an allergic reaction and xenogenic transmission of bovine spongiform encephalopathy remain among its disadvantages.
However , the risk of dysphagia increases with advanced age.
However , the risk of hypoglycemia from some treatments may present the greatest significant barrier to optimal glycemic control for the very old.
However , the risks for adults and pensioners still lie below the risks for Germans in the same age groups.
However , the risks of freezer failure as well as space , cost , and environmental concerns of frozen biospecimens are substantial.
However , thermal perception in cold reflected aging effects rather than local cold acclimatization.
However , the role of AQP4 in plaque formation is not currently clear.
However , the role of associative learning , which is a cornerstone of human cognition mainly relying on hippocampus , has been under-investigated.
However , the role of autonomic nervous activity on AF termination has not been elucidated.
However , the role of BLVRA in the aging process remains unclear.
However , the role of caveolin in regulating insulin signals remains controversial.
However , the role of CD8 T cells in the CNS during acute HIV infection ( AHI ) is unknown.
However , the role of circRNAs in collagen expression during photoaging is still unclear.
However , the role of diet quality ( DQ ) in MS maintenance is still unknown.
However , the role of each nutritional component in the regulation of lifespan is not well established.
However , the role of exercise on the prevention or treatment of immunosenescence is virtually unknown.
However , the role of heparanase in sun-exposed skin remains unknown.
However , the role of hMSCs in the pathogenesis of osteoporosis is still unclear.
However , the role of individual UPR pathways in skeletal muscle has just begun to be investigated.
However , the role of intrinsic and / or extrinsic factors cannot be ruled out.
However , the role of job stress in explaining the life course social gradient in subclinical atherosclerosis is unknown.
However , the role of longer-term consumption patterns in the progression of arterial stiffness over time remains unclear.
However , the role of L-PHP in adult pancreas still needs to be explored.
However , the role of resilience as a buffer against the adverse mental health effects of SLEs in late life has not been convincingly demonstrated.
However , the role of semantic elaboration in mediating valence effects in the aging brain has not yet been explicitly tested.
However , the role of sex hormones , specifically estrogens , on the onset of sarcopenia is controversial.
However , the role of SIRT1 in skin cancer remains unclear.
However , the role of SIRT6 in cellular senescence has not been fully understood.
However , the role of SIRT6 in chondrocytes has not been fully explored.
However , the role of the oncologist remains determinant in the final choice , especially for chemotherapy.
However , the role of the REGγ-proteasome in degrading oxidative proteins remains unclear.
However , the role of these variants in disease progression is less characterized.
However the role of this gene in the colonic mucosa is not understood and whether methylation occurs in subjects without colon cancer.
However , the role of Wnt modulators in this process is unknown.
However , the role of Wnt signalling in male germ cells remains poorly understood.
However , the roles and mechanisms of DNMT1 in skin aging are incompletely understood.
However , the roles of adipocytes in cutaneous biology and disease are not well understood.
However , the roles of AMPK in the pathogenesis of Alzheimer's disease ( AD ) are unclear.
However , the roles of astrocytic Gs-coupled receptors in cognitive function are not known.
However , the role that income plays in influencing access to health services by older adults living in rural areas is relatively unknown.
However , the SA-GCA correlation remained significant after controlling for 3DGI , but not the other way around.
However , the scientific evidence for whether fall prevention prevents fractures is poor.
However , the scientific literature shows mainly the theoretical information about their mutual connections.
However , the scores in the PWS + S treatment did not exceed PLA or PWS responses at any data point.
However , these age-related fMRI increases were differentially associated with task performance.
However , these approaches also suggest that immune activation , blood-brain barrier dysfunction , altered cell metabolic pathways and glial cell injury contribute to pathogenesis.
However , these approaches have yet to be validated outside specialized memory clinic populations.
However , these approaches may be suitable for limited populations and might not be applicable once the HIV reservoir has been established in the brain.
However , the search for a discrete threshold may be futile given emerging evidence.
However , the search for a recurrent cancer-associated gene alteration that causes PTEN degradation has remained futile.
However , these are also potential sources of high-energy toxic byproducts.
However , these associations were lost after full adjustment.
However , these cells show rapid telomere shortening , DNA chromosomal damage , and increased p21 expression that cause cell growth arrest.
However , these changes could be offset by increasing the Medicare eligibility age and the normal retirement age for Social Security.
However , these changes have rarely been studied in relation to each other.
However , these changes in the ability of dual-tasking posture from childhood to old age have not yet been systematically reviewed.
However , these comparisons could suffer from biases arising from vascular and metabolic subject- or time-dependent differences.
However , these complications differ in nature and depend on the filler type used.
However , these correlations do not appear to be unique in individuals with presbycusis as compared with those with normal hearing.
However , these data do not contain information about patient choices of medication or patient commitment to particular medication regimens.
However , these data suggest the possibility for naMCI to have a propensity for increased LBs and aMCI for increased NFTs in select anatomic regions.
However , these defense mechanisms have not been evaluated in elderly women.
However , these dietary behaviors may have a different consequence among adults ( 18-60 years ) experiencing psychosocial stress as measured by food insecurity.
However , these differences were not practically significant , as seen by the resulting profiles of the casework samples ( p = 0.601 ) .
However , these drugs show only modest effects on AD patients.
However , these effects appear to be small in a normal healthy aging population.
However , these effects could be significantly rescued by regulating DNMT1 expression in fibroblasts.
However , these effects disappeared after controlling for comorbidities and physical limitations.
However , these effects have never been compared among MSCs isolated from multiple tissue sources in the same , healthy donor.
However , these effects were similar to PLA responses after 8-weeks of supplementation and inclusion of synephrine did not promote additive benefits.
However , these end-stage cells do not have the shortest telomeres , implicating additional non-telomere-related mechanisms in inducing their senescence.
However , these extracts can also lead to hepatotoxicity , nephrotoxicity and embryonic toxicity.
However , these factors did not exert an opposing effect on VHD and CAD , and the inverse association defied explanation.
However , these findings are based on young healthy individuals , and require validation in elderly individuals and persons suffering from PD.
However , these findings have been questioned because of several possible biases.
However , these findings may not be causal because caregiving and health outcomes were observed simultaneously in our data.
However , these findings suggest that rs-fc may not be sensitive as a marker of HAND among individuals with suppressed plasma viral loads.
However , these guidelines do not specify which intervention activities might be performed.
However , these have been based on the genetic analysis of clinical case-control series.
However , these healthcare professionals must continually update their knowledge as the science of gerontology and geriatrics is always expanding.
However , these impairments may be further impacted by impoverished item representations in material-specific processing regions.
However , these improvements were not accompanied by significant neural adaptations.
However , these innate mechanisms are not @percent@ efficient.
However , these measurements do not always agree and may represent partly different aspects of the underlying Alzheimer's disease pathology.
However , these methodologies are still inefficient and their mechanisms poorly understood.
However , these methods are not feasible in humans and surrogate assays are required.
However , these methods have some disadvantages including high computational cost and slow convergence rate.
However , these methods ignore that there is a deviation between the real age and the brain age due to the accelerated brain aging.
However , these methods require invasive surgical procedures.
However , these minimal differences did not survive corrected thresholds.
However , these negative associations maybe counteracted by BMI > 30 kg / m2 and physical activity.
However , these neurons become vulnerable to the stress of excessive metabolic loads associated with spells of ischemia , trauma progressing to neuronal degeneration.
However , these newly identified AD susceptibility loci exert only very small risk effects and cannot fully explain the underlying AD genetic risk.
However the seniors ' need for telemedical services was more limited and did not exceed the @percent@.
However , the sensitivity and specificity of the SRT was greatly influenced by the level of education of the subjects.
However , the sensitivity of DM to details of the calculation method has not yet been systematically assessed.
However , the sensitivity of the technique is low , particularly for the detection of light-intensity helminth infections.
However , the sentences used in that study were difficult to process and scanpath effects accordingly strong.
However , these pathways do not mature simultaneously.
However , these patients often exhibit adverse effects such as daytime somnolence , poor motor coordination , and an increased risk of falls.
However , these patterns seem to be sex-specific and are not observed in women.
However , these patterns were relatively spatially independent , with small-to-moderate overlap between modalities.
However , these personal narratives are situated in the context of broader cultural narratives.
However , these proteins may all be regulated both developmentally and functionally , restricting their utility.
However , these repositories currently do not provide simple interfaces to systematically analyze collections of related studies.
However , these results could not be correlated since they were ranked using different methodologies.
However , these results were mediated by normal variability in memory function and brain volumes.
However , these results were not relevant to young age group.
However , these results were specific to subjects with low education , suggesting a modifying effect of cognitive reserve.
However , the serum kinetics of sulfatide in kidney disease patients and the function of endogenous serum sulfatide are still unclear.
However , these scores do not predict the clinical response to reperfusion.
However , these significant associations disappeared after further adjustment for energy-adjusted calcium and vitamin D intakes.
However , these significant associations were not observed in women.
However , these studies are observational or cross-sectional and not focused exclusively on the elderly patient.
However , these studies are particularly sensitive to various biases.
However , these studies have been largely observational and provided inconsistent results.
However , these studies include a high percentage of hemophiliacs , which may be a confounding variable.
However , these studies mainly assessed adults in the general population and did not focus specifically on elderly adults.
However , these studies tended to be time-consuming and fairly difficult to implement.
However , these studies used linear models of age correlation , which are not well equipped to model abrupt changes associated with particular ages.
However , these studies utilized six different GWAS arrays making it difficult to conduct analyses of secondary phenotypes or share controls across studies.
However , these studies were of low quality , leading to a grade C level of evidence.
However , these therapies are expensive and require IV infusions @number@ to @number@ times each week.
However , these therapies are expensive and require IV infusions @number@ to @number@ times each week.
However , these treatments adversely affect germ cell survival , and ovarian failure is thus a probable side effect of these anticancer therapies.
However , these trials were heterogeneous in intensity and duration of follow-up.
However , the severity of clinical symptoms of AD is weakly correlated with the plaque load.
However , the sharp-needle technique requires a high level of skill and a good knowledge of facial anatomy.
However , the signaling cascades that modulate the presence of ribonucleoprotein ( RNP ) complexes in SGs are poorly understood.
However , the signaling pathways governing NFκB regulation and function in the brain are poorly understood.
However , the signal sensitivity and the influence of physiological conditions may question the normalization methods.
However , the significance of differences between items and the order of recovery of categories depended on the criterion adopted.
However , the significance of telomere shortening in age-associated decline of immune function is unknown.
However , the significance of two insertions also specific to higher eukaryotic SerRS remains elusive.
However , the simultaneous inhibition of COX-2 in the vasculature translates into a prothrombotic phenotype and promotes hypertension and heart failure.
However , the situation is somewhat different when looking at the amount of the increase.
However , the slope of age-related increase in pentosidine levels was markedly steeper in patients with asthma than in normal controls.
However , the SOF index could not predict subsequent functional decline.
However , the software needs improvement before it is incorporated into research or daily use.
However , the sophistication of medical care and the expansion of the aging society , leads to continuous increase in health-care costs.
However , the source of AA and supplement timing require further investigation.
However , the source of these declines is still uncertain.
However , the source regulator of time-lapse gene expression control still remains unknown.
However , the spatial extent of crowding is a better index of crowding effects and remains unknown.
However , the specific AGEs , sources , and pathways involved remain undefined.
However , the specific contribution of impaired visual spatial attention in falls remains unclear.
However , the specific effect of neuroanatomical aging on the efficiency of economic decision-making is poorly understood.
However the specific gene expression patterns elicited by Rorβ are unknown.
However the specificity for GA for detecting diabetes was @percent@ , while for HbA1c it was higher at @percent@.
However , the stability of these oxidation-induced modifications of hemoglobin remains unknown and whether they can be formed artifactually during storage of DBS.
However , the strategy change may actually be correlated with memory ability as this usually increases with age.
However , the strength of the salivary-serum T relationship may be affected by measurement method and binding capacity with salivary proteins.
However , the strength of this association appears to be overestimated due to the selection bias.
However , the studies were heterogeneous.
However , the study of the kidney response to urinary tract obstruction is only one of several advantages of this model.
However , the study reflects that older adults might feel depressed by not being able to control the result of their reviews.
However , the study was not conducted with a new user design.
However , the study will attempt to modulate immune function using a nutritional supplement and determine the effects on training outcomes.
However , the suboptimum effect on functional parameters should be addressed by increased voluntary activation during WB-EMS application.
However , the success rates of IVF and intra-uterine insemination ( IUI ) in this group remain low.
However , the survival of injected cells in host tissue is limited due to immunoresponse.
However , the symptoms , eosinophilia and imaging findings deteriorated.
However , the synergy indexes were significantly lower than those observed in the earlier study of young subjects.
However , the synergy indices were significantly lower than those of the young subjects during preparation for making a step.
However , the target genes and their functional significance in the senescence and differentiation in normal human oral keratinocytes have been poorly defined.
However , the target ( s ) and mechanism of action of pridopidine remain to be fully elucidated.
However , the temporal relationship between atherosclerosis and telomere length is unclear.
However , the Th17 immune response in the aging process is still not clear.
However , the TH17 / Treg ratio decreased age-dependently after stimulation and was accompanied by elevated Foxp3 mRNA and IL-10 protein expressions.
However , the therapeutic effect of Hsps has not been tested in a relevant setting.
However , the therapeutic use of stromal progenitors holds critical safety concerns due to their potential MM-supporting activity in vivo.
However , the thresholding method was more observer dependent in identifying microbleeds and IDs boundaries than the multispectral approach.
However , the time course for iron accumulation is currently unclear.
However , the timing and appropriate cell number of transplantation to achieve better outcome after an episode of stroke remain further to be optimized.
However , the training needs of the staff who support them has not been subject of extensive examination.
However , the trajectories of PWV and PP diverge with advancing age.
However , the treatment of the primary condition often results in the improvement of the immune compromise.
However , the tubulin acetylation and polymerization state affects the localization of the aggregation.
However , the Turkish biogerontology science needs more manpower , economical and infrastructural and other resources for the promising studies in the future.
However , the two groups did not differ significantly in terms of their performance on the recognition memory test.
However , the two groups had similar execution time for blocks more related to syntactic comprehension.
However , the unavailability of reliable diagnostic tool or gold standard test makes screening difficult to carry out.
However , the underlining molecular mechanisms are not well understood.
However , the underlying anticancer mechanisms have not previously been identified.
However , the underlying biological mechanisms are still not completely clear.
However , the underlying biological mechanisms are still unclear.
However , the underlying cellular and molecular mechanisms remain unclear.
However , the underlying intracellular signalling transduction pathways of α-syn-mediated mDA neurodegeneration remain elusive.
However , the underlying mechanism is not fully understood.
However , the underlying mechanism is not yet clear.
However , the underlying mechanism is unclear.
However , the underlying mechanism of how prelamin A promotes cellular senescence is still poorly understood.
However , the underlying mechanism of this phenomenon is still lacking.
However , the underlying mechanisms and consequences of this phenomenon remain a matter of conjecture.
However , the underlying mechanisms are yet to be determined.
However , the underlying mechanisms of PCD are largely unknown.
However , the underlying mechanisms of stereotype threat in older adults or other stigmatized groups remain poorly understood.
However , the underlying mechanisms remain elusive.
However , the underlying mechanisms remain to be established.
However , the underlying mechanisms remain unclear.
However , the underlying mechanisms remain unclear.
However , the underlying mechanisms still need elucidation.
However , the underlying mechanisms still remain obscure and effective therapeutic strategy is urgently in need.
However , the underlying mechanisms that regulate the internalization and desensitization of GPR40 remain to be elucidated.
However , the underlying molecular mechanism of SIRT1-dependent TERT expression remains uncharacterized.
However , the underlying molecular mechanism remains unclear.
However , the underlying molecular mechanisms are not completely understood.
However , the underlying molecular mechanisms of NAMPT in these physiological and pathological processes are not fully understood.
However , the underlying neural correlates of UFOV performance have not been identified.
However , the underlying neurobiology of this association is unknown.
However , the underlying processes in the development of hand OA are not well understood , and there is no known disease-modifying drug.
However , the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability.
However , the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability.
However , the use of different methods for examining atrophy may be a reason why differences exist.
However , the use of Medicaid financing for services in residential care settings has gradually increased in recent years ( @number@ ) .
However , the use of testosterone replacement therapy ( TRT ) in men with erectile dysfunction ( ED ) has generated an unprecedented debate.
However , the use of VKAs is limited because of the risk of bleeding and the necessity of frequent and long-term laboratory monitoring.
However , the utility of the Japanese equation for estimating glomerular filtration rate ( eGFR ) in cancer patients has not yet been evaluated.
However , the Val393Ala variant was not detected in the above @number@ patients.
However , the validity of EMA data is contingent upon compliance rates.
However , the variant was not associated with plasma NO ( x ) levels in subjects aged≤40 years ( p = 0.799 ) .
However , the vast majority of studies examining preprocessing pipelines in fMRI have focused on young adults.
However , the velocity rate of the increasing was slower in old subjects than in young group.
However , the vital roles of age and MetS-associated risk factors in sex-specific arterial stiffness remain unclear.
However , the volumetric bone mineral density decrease associated with OVX in WT is absent in FLNA-KO-OVX groups.
However , the vulnerability of these cortico-striatal inputs is unclear in these diseases.
However , the widened pulse pressure may be indicative of altered vascular compliance.
However , the withdrawal of FRIDs reduced medication costs with a mean of €38 per participant.
However , they all affect supramolecular assembly of OXPHOS complexes and OXPHOS protein stability.
However , they also might be more expensive , complex and more difficult to use by elderly patients.
However , they are less often malnourished than in French home care settings.
However , they are not always applied by nurses.
However , they are recommended in the recently published German guidelines for the diagnosis and treatment of dementia.
However , they can also cause cardiac complications such as heart failure , arterial hypertension , QT interval prolongation and arrhythmias.
However , they can be unstable and re-release 7KCh.
However , they can lead to incorrect flagging when using automated hematology analyzers for complete blood counts and white blood cell differentials.
However , they differed in composition of other fibre types.
However , they do not interfere in the overall expected dynamics of the populations.
However , they feel that the current level of service does not provide reassurance.
However , they intended to seek assistance in meeting their caregiving roles and responsibilities.
However , they may be disruptive innovations.
However , they observed no significant associations between distant caregiver negative health perceptions and usage of the two integrative strategies.
However they only account for about @percent@ of PD cases , most of the cases likely involving environmental contributions.
However , they reach different conclusions on whether they should introduce policies for older volunteers , and on what policy would be the most suitable.
However , they report a range of challenges in reaching and maintaining this situation.
However , they represent only a small fraction of genes known to be expressed in this region.
However , they were more likely to undergo biopsy and less likely to receive combined radiation and chemotherapy than patients < 70.
However , the γ-aminobutyric acid concentration in the Pelizaeus-Merzbacher disease patient was normalized at @number@ and @number@ months.
However , thickened Bowman's capsule and increased glomerular size appeared specific for the experimental diabetes.
However , this ability often becomes impaired with increasing age.
However , this acute effect appears to dissipate after a few repeated step trials.
However , this AGE-RAGE aging pathway has been under-explored in IPF.
However , this age-related difference was present only for sustained and intermittent isometric contractions , whereas this age-related advantage was lost for dynamic tasks.
However , this approach may need to address different sets of specific factors related to the dizziness categories.
However , this arrest can also curtail the proliferation of stem or progenitor cells and thus hamper tissue repair and regeneration.
However , this article shows that older and younger patients with metastatic colorectal cancer appeared to derive similar survival benefit from bevacizumab treatment.
However , this association did not appear in bedtime glucose.
However , this association is not likely to be causal , with the relevant confounders contributing to this relationship.
However , this association was non significant after controlling for cognitive variables.
However , this association was seen only in men in the US subjects.
However , this attempt of the brain to repair itself was able to only partially rescue cognitive impairment.
However , this basic unit of life is dependent on the proper function of many intracellular organelles to thrive.
However , this benefit was manifested as an increase in recollection in the controls , but an increase in familiarity in the PD patients.
However , this case is an exception as at the age of @number@ years , his power of accommodation has returned to normal.
However , this conclusion is based on a very small sample , selective initials , and a flawed statistical test.
However , this conclusion lacks empirical confirmation.
However , this did not prevent a drop in the ATP content of progeria fibroblasts.
However , this difference disappeared when correcting for height.
However , this effect diminished when including self-rated health and physical activity.
However , this effect is reduced by the presence of peritubular dentin surrounding the tubules.
However , this effect only becomes significant as the PTT value reaches @number@ and above.
However , this element has been detected in neuritic plaques and neurofibrillary tangles in patients with Alzheimer disease.
However this entity seems heterogeneous.
However , this feeling has received less attention than other emotional effects of caring.
However , this formula had no effect on tyrosinase expression in melanocytes.
However , this gene has never been implicated in aging or lifespan regulation.
However , this generalization may not apply to older adults with human immunodeficiency virus ( HIV ) .
However this general paradigm presents with exceptions.
However , this gratifying longevity rise is accompanied by growing incidences of devastating age-related pathologies.
However , this has not been confirmed in Asians with ethnicity-specific variants of MAPT and LRRK2.
However , this has not been demonstrated so far.
However , this has not been studied.
However , this has not led to a corresponding increase in the analysis of large and complex proteins.
However , this has only a minor impact upon MT attachment , indicating that cohesion loss is not the primary cause of aneuploidy in meiosis-I.
However , this has resulted in greater awareness of age-associated diseases such as chronic obstructive pulmonary disease ( COPD ) .
However , this hypothesis does not fully explain all of the molecular abnormalities and is therefore heavily criticized.
However , this idea is negated by experiments on animal models and an observational study on a twin cohort published recently by Karvinen et al.
However , this idealization cannot be reduced only to questions of power and paternalism.
However , this impact on home SHS did not persist after @number@ and the effect of protection was unequal across gender and SES groups.
However , this increase was not observed in elderly subjects who were treated for hypertension.
However , this instrument seems less reliable and valuable compared to the reference instruments used to measure elbow range of motion in gerontology.
However , this intervening period could be a good opportunity for doing further research into personality disorders in older adults.
However , this inverse relationship has recently been challenged , and the neural mechanisms underlying the effects of APOE genotype on Alzheimer's disease remain unclear.
However , this is less the case in community services and can work in focused private practice.
However , this is not always true.
However , this is not only a financial issue.
However , this issue and its corresponding age effects have not been examined directly.
However , this may be complicated by persistent symptomatic vitreomacular adhesions that exert tractional forces on the macula ( vitreomacular traction ; VMT ) .
However , this may be due to a healthy worker effect and / or selection bias.
However , this may not be the entire story , because mTOR is also implicated in a large number of diseases not linked to aging.
However , this may reflect existing co-morbidities rather than an isolated cause.
However , this measure was not changed during preclinical or prodromal Alzheimer's disease and was not associated with amyloid positron emission tomography or APOE genotype.
However , this method has a high specificity ( @percent@ ) and is accurate when it is present.
However , this method of delivery has yet to be evaluated.
However , this model has remained hypothetical since a direct link between BASIGIN and MMPs production has not yet been clearly established.
However , this model remains to be fully investigated.
However , this must not necessarily be true , especially if one notices that cervical joints have a tendency for rapid fusion after surgery.
However , this network correlated with hit rate only for controls.
However , this notion has not been rigorously tested in relation to cortisol-mediated negative feedback.
However , this observation was not superior to age as defined by date of birth.
However , this population tends to suffer difficulties with swallowing.
However , this procedure conflicts with infection control measures and predisposes the patient to further skin breakdown.
However , this procedure has a high potential for increased blood loss , with allogeneic blood transfusions commonly used.
However , this process is time-consuming , and requires specialized equipment and a certain degree of dexterity.
However , this process may be impeded by issues like lack of trust in physician ( TIP ) .
However , this prolonged gaze fixation was minimized when a hand termination was not required.
However , this protection of gender diminishes rapidly after menopause and with advancing age , particularly in obese women.
However , this protection was not substantiated by the analysis of the proliferation of keratinocytes and apoptosis of fibroblasts.
However , this question has been poorly investigated along long-term treatment.
However , this reduced anabolic response can largely be overcome when physical activity is performed in close temporal proximity to protein consumption.
However , this regimen is laborious , requiring trained personnel to open / close the chest tube @number@ times daily for @number@ days.
However , this relationship is not well explored in men with prostate cancer.
However , this relationship remains unclear in children and adolescents.
However , this response could not be explained by the augmented wave reflection.
However , this result has not been obtained with every screening tool , and comparative trials are ongoing.
However , this result has to be investigated in vivo to understand its clinical relevance.
However , this result may not be valid in the long term , and other trials are needed.
However , this review demonstrates that highly polished zirconia yielded lower antagonist wear compared with porcelains.
However , this score dropped to a mean of @number@ ( SD = @number@ ) upon hospital arrival ( P < @number@ ) .
However , this selection advantage diminishes the shorter is the replication time of wt mtDNA in relation to its half-life.
However , this signal did not appear to be independent of APOE.
However , this specific disease is not associated with traditional causes of CKD , such as aging , diabetes , or hypertension.
However , this study finds that the expression and activation levels of Akt in the mice skin increased with age.
However , this study shows that gap detection thresholds can be measured using evoked potential recordings and yield results similar to a behavioral measure.
However , this subgroup of patients is under-represented in clinical trials.
However , this systematic review found a single replicated finding.
However , this topic has scarcely been studied in Latin-America which has particular characteristics regarding aging and urban development.
However , this trend reverses in older ages particularly when females reach menopause.
However , this type of measurement ( timed performance ) will be easy to implement in the clinic.
However , this type of non-parametric inference has yet to be thoroughly compared with traditional parametric inference in VBM studies of brain structure.
However , this underlying aging process remains an abstraction.
However , this variable presents a skewed distribution that difficult data analysis.
However , this view lacks scientific evidence.
However , this was independent of DNA DSBs.
However , this was not the case for the control group , which remained at the same level as pretest performance.
However this was not the case with rhinomanometry values as no significant differences between groups were found.
However , this was partly explained by depressive symptoms.
However , those effects could not be mimicked by increasing the ADMA concentration.
However , those who are immune-suppressed ( e.g. , immunoglobulin deficiencies ) may be at increased risk of recurrent pneumonia.
However , those who cared for a confidant experienced fewer depressive symptoms , independent of the relationship type.
However , those who perceive support from their organizations are also the ones reporting lower life and work stress.
However , those with ≥ @number@ VRFs had greater decrease in FA within multiple WM regions including the splenium of the corpus callosum.
However , those with the susceptibility allele appear unable to decrease expression sufficiently , which may explain their increased risk for developing AD.
However , three-dimensional IMF distribution is not well understood.
However , three out of the four patients undergoing pre- and post-RES neuropsychological testing showed decline in memory function.
However , thus far neuropsychological data about this group are scarce.
However , TMT-A speed and WS are both independent predictors of death after seven years of follow-up.
However , TNF-α is inhibitory at high concentrations.
However , to date and to our knowledge , a direct comparison of non-government vs. government-supported funding models for tele-homecare is particularly lacking in Japan.
However , to date it is still under debate if age-related increases in reaction times are merely an artifact of general slowing.
However , to date it is unclear whether this benefit is different for individuals with strong versus weak executive functioning ( EF ) .
However to date it remains controversial whether persons with MCI can really benefit from cognitive intervention.
However , to date little research has focused on the practice or promotion of health self-management among current and former incarcerated populations.
However , to date most of the knowledge comes from experimental and animal data , which cannot be easily transferred to human situations.
However , to date , most studies focused on arterial CBF ( inflow ) with little attention paid to the age differences in venous outflow.
However , to date , no age-related pathogenic mechanism has been implicated in their formation.
However , to date , no algorithms based on CGA is validated to guide therapeutic decision in geriatric oncology.
However , to date no clear data on the levels of plasma Q during aging are available.
However , to date , no single disease model has serially linked these two pathological events using human neuronal cells.
However , to date , no studies have assessed the effects of age on different structural magnetic resonance parameters in the specific hippocampal subfields.
However , to date no studies have examined visual behaviors during completion of naturalistic tasks in MCI.
However , to date similar strategies have not been successful in human AD patients.
However , to date , the data available on SGK-1 and aging , are sparse , controversial , and only from C. elegans experimental models.
However , to date , therapies based on this knowledge have not been forthcoming.
However , to date this effect has not been identified in human transfusion recipients.
However , to date , underlying neuronal mechanisms of these WM load-dependent activation changes in aging remain poorly understood.
However , today the study of aging is one of the most attractive and prosperous fields in biology.
However , to efficiently implement control of mosquitoes vectors , a reliable estimation of the transmission risks is necessary.
However , to issue a public recommendation of physical activity in aging is not an easy task.
However , too few studies have been conducted.
However , too little attention has been paid to young adult health promotion.
However , to our knowledge , no studies have investigated whether specific genes modify this association.
However , to prevent overdiagnosis and overtreatment , indication for TRT should include both low testosterone levels and symptoms and signs of hypogonadism.
However , to study to what extent such patterns capture meaningful differences in consumption of foods is of interest.
However , to successfully implement AMS programs , there are unique challenges pertaining to this resource-limited setting that need to be addressed.
However , total ankle replacement failures with age often result from talar subsidence , suggesting age-related bone loss in the talus.
However , total body mass includes fat and muscle , which have different metabolic effects.
However , total ( p = 0.04 ) and appendicular ( p = 0.02 ) LBM decreased in the HP group only.
However , to the best of our knowledge , no study has investigated the specific relationship between the caudate nucleus and consumer financial extravagance.
However , to the extent individual fracture sites have differing risk factor profiles , model discrimination is impaired.
However , to what extent the telomere length in peripheral leukocytes reflects telomere length in different organ tissues is still unclear.
However , TP53INP2 is naturally repressed in human insulin resistance and in murine models of diabetes.
However , trabecular number ( Tb.N ) decreased by @percent@ between the middle-aged and elderly groups in women and nearly double that in men.
However , traditional adaptation tasks suffer a number of inherent limitations that may , in part , give rise to this variability.
However , traditional genetic association studies have not found a clear relationship between BDNF and AD.
However , traditional injection techniques have not proven entirely satisfactory in correcting the problem without resulting irregularities.
However , transcutaneous radiofrequency is unable to deliver consistent and measurable temperatures to the hypodermal layers.
However , transgenic overexpression is not suitable for a clinical application.
However , translation of the evidence linking polymorphisms , dietary requirements , and pathology risk proves to be challenging for nutrition and dietetic practitioners.
However , translocation into the ER of a subset of ERAD- and non-ERAD-secreted proteins are regulated by AIRAPL.
However , treatment failures and relapses are common and new markers are needed to identify patients with poor prognosis in prospective trials.
However , treatment with ROS scavenger N-acetyl cysteine can reverse PTEN to a reduced form.
However Treg proportions rose significantly with increasing infection in the younger age group.
However , trends are shown to support early mobilization , less rigid bracing and pharmaceutical secondary prevention.
However , TUG was significantly worse only in the moderate AD group compared with the NC , aMCI , and mild AD group.
However , tumor progression in adult PAs followed a more aggressive clinical course than those in pediatric PAs.
However , tumors rely on residual DNA repair capacities to survive the damage induced by genotoxic stress.
However , two important findings emerged.
However , two other important cholesterol domains are the exofacial and cytofacial leaflets of the plasma membrane.
However , two standard options are available for elderly patients with advanced NSCLC.
However , two-thirds of women continue to experience discrimination , nearly @number@ times the rate in men.
However , type @number@ diabetes mellitus is also advancing in preadolescent children.
However , UI can have significant negative effects on self-esteem and has been associated with increased rates of depression.
However , ultimately , only markers reflecting the function of the vital organs were included in the BA formula.
However , under conditions of chronic oxidative stress , PARP-1 inhibition did not show accelerated telomere shortening.
However , underlying molecular mechanism of PAUF functioning in pancreatic cancer are not fully understood yet.
However , understanding developmental changes of the different cytochrome c oxidase isoforms may have implications for other mitochondrial diseases.
However , understanding how structural changes such as grey matter thinning relate to functional changes is challenging.
However , understanding of how aggregation and deformability are regulated is limited.
However , understanding the biology of autophagy regulation requires pharmacologically active compounds which modulate the autophagy process.
However , understanding the process of MSC aging is crucial for selecting donors for cellular therapies , which is necessary for successful treatment.
However , undertaking a life review requires training and supervision.
However , undifferentiated S-ASCs displayed a faster doubling time coupled to greater proliferation and colony-forming ability than DPSCs.
However , unexpected anatomical variations could also be encountered within the SOV for which the surgeon should be prepared.
However , uniquely , not only overweight but also obesity is protective , which has relevant nutritional goal implications in this population / setting.
However , unique to this study was a significant three-way interaction between age group , evaluative perspective , and domain within bilateral ventral striatum.
However , unlike Drp1 , loss of Marf leads to NMJ morphology defects and extended larval lifespan.
However , unlike EGFR inhibition , depletion of α5 led to substantial suppression of AKT activity.
However , unlike other rapidly evolving functional systems such as sperm-egg interactions and immune defense , the genetic basis of rapid behavioral change remains elusive.
However , unlike the LMWHs , clinical surveillance of the new anticoagulants is challenging.
However , unlike younger individuals , older adults failed to both disengage from the interruption and reestablish functional connections associated with the disrupted memory network.
However , unnecessary automatic eye movements that appear to influence older adults ' NP task performance cannot be identified by strategy reports alone.
However , until now there has been only one attempt to define SE in the international literature ( @number@ ) .
However , until now this approach has not been deployed to study large cohorts of unrelated participants.
However , until the VACS Index is validated in Australia this data may suggest the VACS Index overestimates predicted mortality risk in this country.
However , upon aging and metabolic stress , glucose tolerance is impaired.
However , up to now the molecular interplay between cofilin and drebrin has not been elucidated.
However , urinary incontinence was associated with recurrent falls , but not single falls.
However , usability barriers may differentially affect older adults.
However , usability issues may prevent older adults from easily accessing such information.
However , usage of the interventions was sporadic and declined over time , indicating that future interventions should address stage-specific needs across the caregiving trajectory.
However US- and PO-derived TV are closely related , making PO-derived TV informative enough in the work-up of the infertile man in everyday clinical practice.
However , use and acceptance of the patient controller is relatively low.
However , use of antithrombotic therapy in this population is not well known in the People's Republic of China.
However , use of HRT in the short term did not result in any conclusive trends in skin condition in the majority of users.
However , use of standardised culturally sensitive attitude , and specific symptom , measures are recommended in future prospective studies.
However , use of the vertical bar while lateral stepping over an object in elderly people may need low utilized friction to prevent slipping.
However , using the ecchymosis / hematoma score , no significant difference between Betesil® and aescin @percent@ cream groups was observed.
However , vaccine- preventable diseases still remain a considerable burden and this is particularly true among aging and aged populations in industrialized countries.
However , variability exists in seniors ' responsiveness to training.
However , variance between individuals was large in this dataset which decreases the reliability of the results.
However , variants in the GCKR and PPARG genes had no association with cognitive aging in our study.
However , variation in serum levels of IGF-1 and risk of AD in humans has yet to be determined.
However , variations in normal in vivo anatomy and function according to age and gender remain largely unknown.
However , various mechanisms have been implicated to play a role.
However , vascular risk factor control is frequently poor among stroke survivors , particularly among socio-economically disadvantaged blacks , Latinos and other people of color.
However , very few genetic loci have been identified , and the underlying mechanisms of AFB and NEB are poorly understood.
However , very few research studies have directly examined such correlation in the ageing spine.
However , very few studies are available that have addressed this issue.
However , very few studies have examined the impact of psychological distress on coagulation factors in coronary artery disease patients.
However , very interestingly , we have found a different tendency between Q10 levels and physical activity depending on the age of individuals.
However , very little information is available about the dermatological needs of male skin.
However , very little is known about radiation-induced bystander effect in hSC.
However , very little is known about the function of PICH or how it is recruited to UFBs.
However , very little is known about the role of childhood cognition and educational attainment in this relationship.
However , very little research has been carried out on the role of age in acute stress effects on memory.
However , very-old participants exhibited elevated CVRi and reduced CBF compared to young-old participants in regions implicated in AD and cerebral small vessel disease.
However , virtually all sequence learning studies have displayed successive events one at a time.
However , visual inspection of the biplot showed a trend towards group separation in relation to gait velocity and stance time.
However , visual labeling of sleep stages from EEG requires expertise and is very time consuming , prompting the need for an automated procedure.
However , VNA closely matches HI in populating these profiles.
However , vulnerability can silently or suddenly exist.
However , waist circumference ( @number@ vs. @number@.6cm ) and systolic blood pressure ( @number@ vs. 133mmHg ) were significantly higher in older onset T2DM.
However , we also found detectable signatures specific for DS among subdominant GM components , such as the increase of Parasporobacterium and Sutterella.
However , we also observed functional reorganizations in parieto-occipital areas , and with increasing WM demands , an aging-related reversed hemispheric asymmetry of prefrontal activations.
However , we and others have recently shown that its cognate interacting partners are CDK12 and CDK13 in mammalian cells.
However , we argue that the signal still reached the necessary threshold to trigger normal post-error adjustments.
However , Web-based interventions are often characterized by high rates of attrition.
However , we can not exclude that chronic airway inflammation may contribute to sympathetic activation.
However , we could not detect any individual-unique mutations of known genes responsible for major progeroid syndromes.
However , we could not find the meaningful OPTN mutations.
However , we demonstrate how deteriorating health and reductions in height occur simultaneously.
However , we did find reduced grey matter volume on MRI in our HIV-positive participants within the medial and superior frontal gyri.
However , we did not detect any association of rs3818292 and rs4746720 with MI risk.
However , we did not find any rules determining the density of nerves according to muscle fiber type and the mode of muscle activity.
However , we did not find evidence to support a steadily progressive and degenerative course of the disorder when patients were analysed as a group.
However , we did not observe any associations between these smoking indicators and 8-oxodG levels.
However , we do know that these personal and economic costs can be avoided through injury prevention activities.
However , we do not find a strong association between the type of health insurance and health behavior.
However , we do not know what impact driving anxiety has on health and well-being , especially among older drivers.
However , we failed to find sex differences in memory performance.
However , we focused on LCSS only.
However , we found a significant emotional memory advantage for negative words in all @number@ diagnostic groups.
However , we found four relatively new classes that showed significant association with recurrent falls.
However , we found no effect of obesity on the overall survival of patients with HCC.
However , we found no evidence of an association between rare inherited variants of mtDNA or mtDNA heteroplasmy and disease.
However , we found no evidence that FSRP is an early biomarker of MCI.
However , we found no hippocampal volume differences between APOE groups in healthy 14-year-old adolescents.
However , we found no significant differences in IVR between the two groups ( p = @number@ ) .
However , we found significant contraction of nucleus accumbens in CA compared to HCs.
However , we found that activated memory B cells from older people produce higher levels of IL-6 and IL-10 compared to young adults.
However , we found that for temporally correlated data , SE value depends on the sampling rate.
However , we found that the HEI-2005 is not a good measure of healthy eating for optimal bone health.
However , we have not identified any patients with CS who have received metronidazole without serious adverse effects.
However , we have very few clinical-pharmacological data on the use of major tranquilizers including anti-manic drugs for elderly patients.
However , we know little about the impact of Web-based interventions for informal caregivers of community-dwelling adults with chronic conditions.
However , we know little of how parental disease activity before conception influences offspring's asthma and allergy in humans.
However , well-controlled experimental data obtained in human subjects are still in need of further development.
However , we must first understand how the performance develops in children who do not have a disorder.
However , we note that despite being widely used and promoted , the Active Ageing Index remains under-scrutinized.
However , we observed an association between a high level of education / training experience and higher knowledge scores.
However , we observed no relationship between general trust and health outcomes.
However , we observed opposite effects in women and men with respect to cardiovascular and cancer mortality.
However , we observed substantial between-country disparities in RA mortality , although these disparities decreased over time.
However , we predict a @percent@ diminution of the sterilizations by tubal implants.
However , we predicted that the \ "motor \ " circuits would show less variation in connectivity strength across the lifespan.
However , we project that there will be a @percent@ increase in the number of used liver grafts.
However , we provide evidence of protection against severe disease by RSV-matAb during the first 6-7 months.
However , we provide first evidence of an association between global structural brain network properties and general intelligence in advanced elderly.
However , we recommend further testing the long-term effects of this program on a larger population.
However , we should not expect a major decrease or improvement in cardiovascular risk factors with such a short follow-up.
However , western blotting of mitochondrial fractions from PD and control brains indicates significantly less Hb in PD brain mitochondria.
However , We / Us caregivers expressed more positive aspects of caregiving than I / Me caregivers.
However , whatever epigenetic repair is induced by transient reprogramming does not endure and may be due to the induction of key homeostatic regulators instead.
However , what happens in practice falls short of what the Brazilian Constitution sets forth.
However , when adding the knee baseline KL score to the model the AUC increased to @number@
However , when aging is not associated with the word active , it is still represented as losses and disabilities.
However , when analyzed for each gender , epidermal tsGAG , tUA , and tissue water decreased only in females.
However , when analyzed in individual bones , the BMD of the appendicular skeleton in OA-affected joints may decrease , particularly in the upper extremities.
However , when both local motion and global form information were present in the display , older subjects were less accurate then younger subjects.
However , when cellular damage exceeds certain threshold levels apoptosis is initiated.
However , when chronically altered , these responses become conserved causes of aging and cancer.
However , when considered together , combinations of these constructs more strongly predicted adverse health outcomes.
However , when controlling for age , only phonation quotient and F0 during reading were significantly lower in the group of postmenopausal women.
However , when examined together in a multivariate logistic regression , only discordant PiB remained significant ( adjusted p = @number@ ) .
However , when excluding women with menopausal age < 40 years , the association decreased to @number@ months ( @number@ to @number@ ) .
However , when fat mass accumulation reaches excessive levels , unfavorable metabolic changes may impede skeletal development.
However , when fever is present and there are no localizing findings , symptomatic infection is a diagnosis of exclusion.
However , when followed over time , this sample showed reduced frontal recruitment.
However , when follow-up started at old age ( 70-80 years ) there was no significant association between education and dementia related death.
However , when patients with established AD were supplemented with EPA and DHA it appears no benefit was gained.
However , when performing additional adjustment for health covariates , only the domain Health and mobility remained significantly associated with physical frailty.
However , when recalcitrant , such as long-standing onychomycosis , prescription medications may be warranted.
However , when regression analysis included multiple disease-severity measures , independent associations with costs were noted for the different measures.
However , when responding with this strategy , both young and older adults demonstrated few changes immediately following moderate-intensity physical activity compared with before.
However , when ROS generation exceeds endogenous antioxidant capacity , oxidative stress arises.
However , when site-specifically corrected , the uHear application may be used as a screening tool for hearing loss in an elderly population.
However , when SMC was present a reverse association was found for SRH : good SRH increased NH placement.
However , when stratified by age , the GG genotype increased the risk of early-onset AD.
However , when the analysis was done separately for clozapine and olanzapine , a significant difference remained only for olanzapine.
However , when the effect of aging was controlled , the only significant correlation remaining was between the reversal adaptation magnitude and spatial working memory.
However , when the inflammatory insult is intractable , or the cause has not been diagnosed , there are limited options for treatment of AI.
However , when these factors were controlled through a partial correlation , correlations between glutathione concentrations and dairy and milk servings remained significant.
However , when the SNR is high , it can lead to a reduction of signal amplitude.
However , when transiently present , senescent cells promote optimal wound healing.
However , when using non-modeled mortality rates , senescence rates were yielded at young and old ages that remained concealed when using modeled mortality rates.
However , when we controlled for children's memory for the problem , there were no longer significant age-related changes on the item choice measure.
However , where and how this model must be realized is still questionable.
However , whether age-related reductions in asymmetry of hemispheric activations affect the symmetry of motor behavior in older adults remains largely untested.
However , whether and how FOXOs function in OIS have been unclear.
However , whether and how TICs specifically recruit macrophages and the function of these macrophages in tumor initiation remain unknown due to technical difficulties.
However , whether and in which way skin is a target of specific disease alterations in DM1 and DM2 has not been yet clarified.
However , whether and / or how ER stress and the UPR contribute to the pathogenesis of metabolic syndrome and obesity is not entirely clear.
However , whether arthroplasty is associated with lower mortality and complication rates in non-displaced or mildly displaced PFFs is unknown.
However , whether autophagic structures per se regulate cell signaling was not known.
However , whether baicalin can regulate Aβ-induced microglial activation or inhibit inflammatory cytokine secretion has not been confirmed.
However , whether biomaterials are associated with the senescence of cultured cells is not known.
However , whether declined brain function or volume with aging causing metabolic changes is unknown and should be further evaluated.
However , whether fibre extracts provide similar health benefits to the fibre supplied in the constituents of whole grain is largely unexplored.
However , whether GLP-1 regulates osteoblastic differentiation of VSMCs and associated molecular mechanisms has not been clarified.
However , whether Hcy activates 5LO enzymatic pathway by influencing the methylation status of its promoter remains unknown.
However , whether higher muscle mass is associated with higher muscle quality ( muscle strength relative to muscle mass ) remains unknown.
However , whether higher order cognition might in fact lead to a more resilient brain has not been quantitatively demonstrated yet.
However , whether HuR binds to circular RNAs ( circRNAs ) and impacts on their function is unknown.
However , whether inter-individual variability in analogical reasoning ability in a healthy adult population is related to differences in brain architecture is unknown.
However , whether it is a unique interstitial disease needs to be further clinically investigated.
However , whether mammalian microRNAs are methylated is unknown.
However , whether MCL can inhibit neuroinflammation caused by LPS-activated BV2 microglia has not yet been explored.
However , whether MLN4924 has any effect on renal carcinoma cells ( RCC ) remains unexplored.
However , whether musical sensorimotor and cognitive abilities transfer to nonmusical cognitive abilities that are maintained throughout the life span is unclear.
However , whether Notch4 is also involved in brain AVMs in humans remains unclear.
However , whether older people have more traffic accidents than other age groups is unclear.
However , whether or not aMCI also alters the effective connectivity ( EC ) of the DMN remains unknown.
However , whether or not NBP confers neuroprotection in parkinsonian models is still unknown.
However , whether overall or abdominal obesity better explains senior adults ' hypertension has not been studied.
However , whether PPI deprescribing translates into better clinical outcomes remains unclear.
However , whether reversible disulfides can be predicted based on structural information remains largely unknown.
However , whether serum FGF21 is independently associated with atherosclerotic diseases remains unclear.
However , whether testosterone supplementation could be useful in the treatment of testosterone-deficient elderly men is still controversial.
However , whether the aberrant expression of EWSAT1 in NPC is corrected with malignancy or prognosis has not been expounded.
However , whether the aberrant expression of LOC100129148 in NPC is corrected with tumorigenesis or prognosis has not been investigated.
However , whether the accumulation of DNA damage with age is a result of decreased repair capacity , remains to be determined.
However , whether the DNA damage and repair capacity can be a biomarker of aging remains controversial.
However , whether their combination may lead to a worsening status in those patients remains unclear.
However , whether the mortality benefit persists in elderly patients is not clear.
However , whether the pathophysiology of MCI extends to speech processing before conscious awareness ( brainstem ) is unknown.
However , whether these findings can be extended to kinematic variables associated with motor coordination remains largely unknown.
However , whether the SSAO increase constitutes a cause or it is a consequence of the pathologic process has not been elucidated so far.
However , whether this ingestive behavior influences meal size in older adults is unknown.
However , whether this process is reversible through smoking cessation is not known.
However , whether this sleep-based memory consolidation changes as a function of age remains controversial.
However , whether Tint reflects Trec during prolonged , intense and continuous exercise when cold fluids are consumed is unknown.
However , whether visfatin is a friend or a foe in these diseases remains uncertain.
However , which genes underlie this relationship is unknown.
However , which of these encode proteins suitable for drug targeting is unknown.
However , while aging may facilitate evolvability , it need not result from a program specifically selected for that purpose.
However , while some studies of apoE levels in plasma have presented correlations with AD pathology , others have not.
However , while the effects of age are easy to recognize , identification of the processes involved has proved to be much more difficult.
However , while the public rank it second in implementation priority , following timely access , the majority of professionals rank it only fourth.
However , while these factors tend to increase the degree of sensitization in the elderly , waning immunity can actually decrease such a propensity.
However , widely-used metrics developed to quantify its extent are unable to distinguish between uniaxial and multidirectional flows.
However , wider implementation of fall prevention activities in routine care has yielded mixed results.
However , wider implementation of such ideas is compromised because of little advances in modification of the metabolic rate.
However , with age , mutant testes showed defective spermatogenesis , progressive germ cell loss , and flawed meiotic entry of spermatogonial cells.
However , within recent years , it has become increasingly evident that a fraction of lamins also resides throughout the nuclear interior.
However , within the most disadvantaged @percent@ of neighborhoods , rehospitalization rates increased from @percent@ to @percent@ with worsening ADI.
However , within the older population , individuals who demonstrated face-expectation memory benefits also exhibited expectation-period FFA activity modulation equivalent to younger adults.
However , with modifications to the IMUs selection , we were able to detect these activities with @percent@ accuracy.
However , with new technological advances , the benefits of identifying genomic profiles became apparent.
However , with @number@ permutations there were approximately @percent@ more statistically significant voxels ( N = 7117voxels ) than with ≥10000 permutations.
However , without a specific designated clinic follow up , these patients often fail to get the appropriate care required.
However , with recent advances , their role as a rheostat that fine-tunes stem cell self-renewal has begun to emerge.
However , with the addition of WT during GVS , OA also stiffened their trunk.
However , with the aging of these patients , many late complications have been reported , and this notion must be reevaluated.
However , with the exception of dual tasking , the key components of EF that predict differences in gait performance have not been determined.
However , with the industrialization of the world , activities that disrupt endogenous homeostasis with external circadian cues have increased.
However , with the repetition of injections , a new concern has emerged : clinical resistance and loss of effectiveness of the treatment.
However , WMH did not correlate with neuropsychological performance in BD subjects.
However , women had poorer mental health , worse physical function , more pain , and lower quality of life compared with men.
However , women have smaller muscles throughout the adult life.
However , women's errors remained leftward biased , and did not significantly change with age.
However , women with higher ELF experienced faster senescence in offspring survival.
However , wood treated with CCA has been restricted from residential uses in the EU from @date@ , due to its potential toxicity.
However , word finding failure rates correlated negatively with a more restricted region in the posterior aspect of superior longitudinal fasciculus.
However , wrinkled-skin fi broblast lattices failed to show appreciable contractions ( to @percent@ after three days ) .
However , younger adults used a flexible encoding strategy to remember the social interaction partners.
However , young women are at risk of experiencing SMW.
However , ZNF216 overexpression has been reported in medulloblastomas and metastatic nasopharyngeal carcinomas.
However , βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases ( HDACs ) .
However , Δ leptin and ΔPYY were not significant predictors of the differences between postintervention measurement and predicted REE.
However , Δ leptin and ΔPYY were not significant predictors of the differences between predicted and measured REE after the intervention.
How exactly these two pathways cross talk to each other is unclear.
How faces change across lengthy time periods and whether the changing appearance of a face functions as an identity category was investigated in two experiments.
How factors associated with aging contribute to the development of CTS remains to be determined.
How HAART affects this condition is an open question.
How has your approach to or technique in chemical peels evolved over the past several years ?
How have they been treated by those who have received them ?
How is being hungry prolonging the life span ?
How lamins interact with other nucleoskeletal components , and even the identities of these other components , are open questions.
How Lebanon manages these challenges is likely to foreshadow the future aging experience for much of the Arab region.
How mammalian oocytes successfully navigate their exceptional meiotic journey has long been a question of immense interest.
How metaproteomics will affect next-generation diagnostics and preventive medicine ?
How mitochondrial dysfunction causes cell degeneration is not well understood.
How nutrient- and insulin-sensing mammalian target of rapamycin ( mTOR ) pathway can drive insulin resistance and diabetic complications.
How older people spend their time in different occupations could contribute to our understanding of everyday life in healthy ageing.
How old is too old to be a father ?
How old one feels-one's subjective age-has been shown to predict important psychological and health outcomes.
How optimistically individuals view their future and what they expect from it has often been studied in younger adults.
How p53 is activated in response to progerin production is unknown.
How p73 is able to participate in such a broad spectrum of different biological processes is still largely unknown.
How people spend their \ "young old age \ " has become increasingly important.
How PGRN prevents lysosomal dysfunction with aging remains to be elucidated.
How PSEN1 mutations cause FAD is unclear , and pathogenic mechanisms based on gain or loss of function have been proposed.
How service users conceptualise their personal support services is under researched , even though this understanding is important for responsive policy development and service implementation.
How sex steroids modulate glucocorticoid feedback on the ( HPC ) unit is controversial in humans.
How should it respond ?
How sociocultural contexts shape individual functioning is of prime interest for psychological inquiry.
How stem cells maintain metabolic homeostasis remains elusive.
How such regeneration is terminated is uncertain.
How the epidermal microenvironment controls melanomagenesis remains poorly understood.
How the grade of microbial virulence is controlled at the community level ?
How the polycomb is recruited to repress this gene cluster is unclear.
How these associations evolve from young adulthood forward is unknown.
How these cell surface proteins regulate satellite cell self-renewal is incompletely understood.
How these diverse cells and how these different organelles communicate with each other in time and space are scientific questions that intrigue me.
How these innovations may impact and be leveraged into the development of new products in PC is also discussed.
How these molecular events change during aging and in glaucoma pathology remain unresolved.
How these multi-factorial risks interact in individual patients remain poorly understood.
How these mutations impact upon telomere function is unknown.
How these plastic changes affect the ability to integrate combined auditory ( A ) and visual ( V ) information is not yet well understood.
How these risk factors interact to drive disease onset is currently unknown.
How they experience their aging process in terms of their singlehood and vice versa.
How they experience their aging process in terms of their singlehood and vice versa.
How this growth will continue in the next years is uncertain.
How this normative variation relates to older-adult value-based decision making is unclear.
How this OVP effect changes with age is unknown but may differ for older adults due to visual declines in later life.
How to disentangle its effect from that of the antidepressants is the methodological challenge to be overcome in future studies.
How to inhibit osteoclast activity is the key issue for osteoporosis treatment.
How to warm these patients and maintain a desirable temperature throughout the examination is vitally important.
How TREM2 deficiency mediates demyelination and disease is unknown.
How XRCC1 responds to SSBs after pAR degradation and how this affects repair progression are not well understood.
HOXA4 was chosen for further study , since it had decreased expression in the abdominal compared to the thoracic aorta.
HP 1F / S subtyping was also performed to check the possible existence for a preferential advantage of HP 1F or HP 1S allele.
HPAA activity was assessed by quantifying cortisol levels in first morning urinary specimens collected every other day for seven weeks in @number@
HPA axis activity did not explain these differences.
( HPA ) axis dysregulation associated with major depressive disorder ( MDD ) was previously reported to be higher in the elderly.
HPA axis regulation was assessed by four morning saliva samples , two evening samples , and one awakening sample after @number@ mg dexamethasone.
HPA axis responses were measured at age @number@ by randomly assigning children to one of two laboratory stress tasks ( frustration vs. fear ) .
( HPB ) surgery encompasses major hepatic resection and pancreatic surgery , both procedures of high complexity with a potentially high complication rate.
HPC activation in CHC is a common but diverse phenomenon closely related to patient age and hepatitis stage.
HPD and SFN may therefore represent promising antiphotoaging candidates.
HPF cells were treated with @number@ pmol / L H2 O2 four times to build oxidative-stress inducing premature senescenct model.
HPI was categorised into three groups by the score of 0-2 , 3-4 and 5-6.
HPSV was determined by abolishing RPS with pharyngeal anesthesia.
HPV32 seems to be much more prevalent in asymptomatic HPV infections and warts among those infected with HIV than among those in the general population.
HPV positives were further tested for high-risk HPV16 , @number@ @number@ and low-risk @number@ using real-time PCR.
HPV-related cancers seem to have better prognoses and different risk factors than do HPV-negative ones.
HP was defined as a condition with thickening of the cranial or spinal dura mater with inflammation , evidenced by MRI or histology.
Hp with antral predominant gastritis is responsible for an increased gastric acid secretion and thus promotes GORD.
H. pylori eradication improves the symptoms of functional dyspepsia , but only in a minority of patients.
H. pylori infection status , histological severity of gastritis , and serum pepsinogens ( PGs ) were also investigated.
H. pylori is the main cause of \ "aging \ " of the human stomach.
H. pylori status was assessed by histology plus the rapid urease test or 13C-UBT.
Hradec Kralove.
HR and high frequency HRV ( HF HRV normalized units ; @number@ @date@ Hz ) were measured during resting state and stress.
HR and SNS index decreased and PNS index increased in all intervention groups but reached significance only in CREX.
HR and SNS index increased and PNS index decreased in response to the meal in all intervention groups.
HR , BP , DoP , RPP , and TC decreased significantly following yogic practice.
HR , core ( Tcore ) and mean skin ( Tsk ) temperatures were measured continuously.
HR corrected RV IVA ( RV IVAc ) is independent of age , BSA , gender , and HR.
H reflexes were evoked in the ECR by stimulating the radial nerve above the elbow.
HRF measures were taken before and after a 16-week TC program that offered seven sessions per week.
HR in the EXP group compared with the TAU group was @number@ ( p = @number@ ) .
HRM was performed using solid-state manometric assembly with @number@ circumferential pressure sensors ( MMS , Netherlands ) .
HR occurred in @percent@ of patients , and mortality was @percent@.
HR-pQCT scans were downscaled to a voxel size of 250μm.
HRQoL and psychological adjustment data were measured by standardised , parent- and self-reported questionnaires.
HRQoL and several indicators of cardio-metabolic status and fitness were assessed.
HRQOL expectations were recorded by applying the EQ-5D descriptive system for @number@ months ahead and for future ages of @number@ @number@ @number@ and @number@ respectively.
HRQoL was assessed using EuroQol-5 dimension ( EQ-5D ) and EuroQol-visual analog scale ( EQ-VAS ) at baseline and after a 3-month follow up.
HRQoL was assessed using the EuroQol visual analogue scale.
HRQOL was assessed using the Minnesota Living with Heart Failure questionnaire.
HRQoL was assessed using the SF-36 questionnaire.
HRQoL was assessed with the EuroQoL-5D.
HRQoL was measured at baseline and at @number@ months follow-up using the EuroQol-5D and Short Form-12 version @number@
HRQOL was measured by the SF-36 Taiwan version at @number@ @number@ @number@ and @number@ months after discharge.
HRQoL was measured by the specific Parkinson's disease questionnaire ( PDQ-39 ) .
HRQoL was measured with the SF-12 and LS with the life satisfaction index A ( LSI-A ) .
HRQoL was significantly and independently associated with poor mobility and pain and remained significant after adjusting for variations in clinical characteristics.
HRs for LVH were @number@ ( @number@ @date@ ) for all-cause and @number@ ( @number@.89-6.67 ) for cardiovascular mortality.
HRS women completed six interviews ( one every other year ) from @number@ to @number@
HRT also tended to increase the OGA mRNA level compared to the controls.
HRT must be individualized and tailored according to symptoms and each woman's individual risk profile , her preferences and expectations.
HRT use for at least @number@ years , when administered within a 5-year perimenopausal window , was associated with decreased decline in global cognition.
HRT users and non-users did not differ in LTL or mean or minimum SMTL.
HRV allows simultaneous assessment of both sympathetic and parasympathetic activity and the interplay between them.
HRV analysis provides insights into mechanisms of autonomic regulation and is extensively used to clarify relationships between depression and cardiovascular disease.
HRV assessment was performed through linear and non-linear analysis of cardiac interval variability.
HRV has been found useful in the study of cardiological illness in adults and elders , as well as in monitoring prenatal health.
HRV indices were divided into quintiles for comparison of values and cognitive performance was defined using the Montreal cognitive assessment ( MOCA ) score.
HRV is defined as fluctuations in interbeat interval length which reflect the heart's response to extracardiac factors that affect heart rate.
HR , V˙O2max , ventilation , and running economy were measured in @number@ @number@ and @number@
HRV triangular index ( HRVi ) was lower ( P = 0·012 ) in RLS group.
HR was diminished in the Nonsmoker Group in comparison with the Ex-smoker Group ( p = @number@ ) between the first and last evaluation.
HS-1793 also inhibited VEGF level.
HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent fashion.
HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent manner.
HS68 cells were transfected with small interfering RNA against Nrf2.
HS-Aging is also strongly associated with TDP-43 pathology.
HS-Aging pathology appears to be most prevalent in the oldest-old : autopsy series indicate that 5-30 % of nonagenarians have HS-Aging pathology.
HSA parameters are reported for three standard regions of the proximal femur ( narrow neck , intertrochanteric , and shaft ) .
HS cases commonly coexisted with TDP-43 pathology ( @percent@ ) , which was more severe ( p < @number@ ) in HS cases.
HSCs and myofibroblasts were also noted to express collagen IV , which may contribute to production of basal lamina-like structures.
HSCs exist in very low frequencies within specific \ "niches \ " where they interact with the surrounding environment through molecular associations.
HSCs from AhR ( - / - ) knockout ( KO ) mice are hyperproliferative and have an altered cell cycle.
HSCs make a choice of either self-renewal or committing to differentiation.
Hs-cTnT was measured during a visit to the emergency or outpatient department.
HSC was computed as a standardized function of HMO costs for each individual.
HSOA participants had less hospital care when matched for falls status.
HSP27 content was upregulated in all groups studied postexercise.
HSP72 content was upregulated to a greater extent in muscle of trained compared with untrained subjects postexercise , irrespective of age.
HsPDA resulted in a significantly lower PSS in the LV free wall as of day @number@ ( P < @number@ ) .
Hsps are molecular chaperones characterized by their protective activity against different types of stress.
HSVL was underestimated when using only current data in each interval.
HS was defined as severe neuronal loss and gliosis in the hippocampal CA1 and / or subiculum.
HT4 and HT52 mutually enhanced TLR4 inhibition.
HTA implementation in Japan has been criticized , saying that it might prohibit patients ' access to medical treatments.
HT-associated reductions in hippocampal volumes were greatest in women with baseline 3MS scores < or = @number@
HTN results from a complex interplay of genetic and environmental factors.
HTR2A and HTR2A gene variations are implicated in depression , schizophrenia , anxiety and obsessive-compulsive disorder.
HTR2A mRNA levels were assessed using quantitative real-time RT-PCR and HTR2A protein levels - with Western blot.
HT showed an increased M / L ( P < 0.001 ) versus control.
HT suppressed age-associated increase in mitochondrial ROS levels.
HT users outperformed never users and men in visual divided attention.
HT users outperformed never users in updating.
Huddles provided LTC staff with the opportunity to collaborate and discuss strategies to optimize resident care.
Hu et al. show that disruption of the epidermal barrier increases serum cytokine levels partly because of increased cytokine production by the skin.
Huge contributions of basic and clinical studies have established clinical evidence supporting these markers.
Huge costs are placed upon sufferers and health providers , aggravated as serious and disabling complications develop.
Huge number of subordinates who have no right to take part in reproduction and hence in evolution serves the small queen's family.
Human abdominal subcutaneous fat tissues were obtained by simple liposuction from donors , and ASCs were isolated from the fat stromal vascular fraction.
Human activity , life span , and quality of life are enhanced by innovations in science and technology.
Human adipose tissue is a great source of autologous mesenchymal stem cells ( hASCs ) , which are recognized for their vast therapeutic applications.
Human adult aging is associated with a loss of strength , contractile velocity and hence , power.
Human age , as an important personal trait , can be directly inferred by distinct patterns emerging from the facial appearance.
Human ageing affects the immune system resulting in an overall decline in immunocompetence.
Human aging is accompanied by both vascular and cognitive changes.
Human aging is a complex process that includes chronological and biological aging.
Human aging is a multifactorial process.
Human aging is associated with a loss of skeletal muscle and an increase in circulating inflammatory markers.
Human aging is associated with a reduction in appetite and food intake.
Human aging is associated with bone loss leading to bone fragility and increased risk of fractures.
Human aging is associated with increasing frailty and morbidity which can result in significant disability.
Human aging is associated with the deterioration of long-lived proteins.
Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system.
Human aging is characterized by changes in the immune system which have a profound impact on the T-cell compartment.
Human aging is characterized by declines in cognition and fine motor function as well as improved emotional regulation.
Human aging is commonly accompanied by low-grade inflammation in both the immune and central nervous systems , thought to contribute to many age-related diseases.
Human allogeneic mesenchymal stem cells ( allo-hMSCs ) exert immunomodulatory effects and promote tissue repair.
Human alpha-1 antitrypsin ( AAT ) is an abundant serum protein present at a concentration of @number@.0-1.5 g L ( @number@ ) .
Human amniotic fluid cells ( AFCs ) are routinely obtained for prenatal diagnostics procedures.
Human and AD mouse model microvessel images were quantified with HAMAMATSU imaging software.
Human and animal models have identified numerous links between DNA methylation and inflammatory biomarkers.
Human and mouse alkaline phosphatases ( AP ) are encoded by a multigene family expressed ubiquitously in multiple tissues.
Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging.
Human and murine anti-Hb monoclonal antibodies were generated , some of which were preferentially reactive toward disease-associated methemoglobin.
Human aortic tissue samples were used to develop the code.
Human arteries exposed to d-flow had similar increases TSP-1 and collagen gene expression as seen in our model.
Human arteries from regions of d-flow and stable flow were tested ex vivo to validate critical results from the animal model.
Human ASCs were transplanted in the ALS mice at @number@ postnatal days before the appearance of clinical symptoms.
Human atrial myocytes were acutely isolated and the whole-cell patch clamp technique was used to record sodium currents isolated from pediatric and adult atrial cardiomocytes.
Human AβPP was not only expressed within the brain of these mice but also in gut tissue.
Human behaviour is made up of many repeated patterns and habitual behaviours.
Human beings have been recently reviewed as ' metaorganisms ' as a result of a close symbiotic relationship with the intestinal microbiota.
Human blood plasma is a complex biological fluid containing soluble proteins , sugars , hormones , electrolytes , and dissolved gasses.
Human body has evolved an effective defense system including superoxide dismutase ( SOD ) and catalase against the toxicity of these free radicals.
Human bone marrow-derived multipotent stromal cells ( MSCs ) have been applied in the treatment of fracture nonunion.
Human brain development has been studied intensively with neuroimaging.
Human brain function undergoes complex transformations across the lifespan.
Human brain imaging has seen many advances in the quantification of white matter in vivo.
Human Brain Mapping 31 : 835-837 , @number@ ) .
Human brain maturation is characterized by the prolonged development of structural and functional properties of large-scale networks that extends into adulthood.
Human bursa was obtained from patients undergoing rotator cuff surgery and cells within were isolated using collagenase and dispase digestion.
Human butyrylcholinesterase ( BChE ; EC @number@ ) and human acetylcholinesterase ( AChE ; EC @number@ ) are irreversibly inhibited by CBDP.
Human butyrylcholinesterase ( BChE ) functions as a bioscavenger , protecting the cholinergic system against OPs.
Human cardiac progenitor cells ( hCPC ) improve heart function after autologous transfer in heart failure patients.
Human-cat dyads may be similar in interaction structure to human dyads because many humans regard their cats as being social companions.
Human CDCs were isolated from heart failure patients of various ages ( 2-83 years old ) .
Human cells utilize a variety of complex DNA repair mechanisms in order to combat constant mutagenic and cytotoxic threats from both exogenous and endogenous sources.
Human chromosome ends associate with shelterin , a six-protein complex that protects telomeric DNA from being recognized as sites of DNA damage.
Human cognitive aging differs between and is malleable within individuals.
Human cognitive processing limits can lead to difficulties in performing two tasks simultaneously.
Human cutaneous photodamage is a major medical problem that includes premature aging and fragility of the skin.
Human cyclic AMP response modulator proteins ( CREMs ) are encoded by the CREM gene , which generates @number@ or more different CREM protein isoforms.
Human cystatin C ( hCC ) is a small protein belonging to the cystatin family of papain-like cysteine proteinase inhibitors.
Human cytomegalovirus ( HCMV ) is a ubiquitous beta human herpesvirus type @number@
Human dental pulp stem cells ( hDPSCs ) has a remarkable rejuvenated capacity that relies on its resident stem cells.
Human DNA is the main unit that shapes human characteristics and features such as behavior.
Human endogenous retroviruses ( HERVs ) have been implicated in human physiology and in human pathology.
Human endothelial cells were cultured in conditioned media of mesangial cells exposed to @number@ mM high glucose ( HG-HRMC-CM ) .
Human epithelial cells undergo morphological and molecular changes leading to terminal differentiation and replicative senescence after a finite number of cell divisions during serial subculture.
Human erythrocytes are highly specialized enucleate cells that are involved in providing efficient gas transport.
Human evolution suggests that the default position for health is to be physically active.
Human exome sequencing has dramatically increased the rate of identification of disease-associated polymorphisms.
Human exposure to arsenic in drinking water is known to be associated with the development of bladder , lung , kidney , and skin cancers.
Human female reproductive aging consists of multiple processes and interacts with other physiological systems in unique ways.
Human fibroblasts nuclear extracts from @number@ donors of different ages were characterized in their ability to simultaneously excise the different lesions.
Human flourishing represents a state of mental health in which an individual is actively striving to live well rather than merely feeling good.
Human foreskin fibroblasts , Hs68 cells , at an initial passage of @number@ were serially cultured for several months until they reached cellular senescence.
Human genes without orthologs in distant species ( 'young ' genes ) tend to be tissue-specific in their expression.
Human genetic factors predispose to tuberculosis ( TB ) .
Human genetic mosaicism is the presence of two or more cellular populations with distinct genotypes in an individual who developed from a single fertilized ovum.
Human genetics is a powerful tool for discovering causal mediators of human disease and physiology.
Human genetic studies are rarely conducted for immunological purposes.
Human hair follicles ( hHF ) contain keratinocytes having the property of stem cells such as clonogenic potential.
Human height variation is determined by genetic and environmental factors , but it remains unclear whether their influences differ across birth-year cohorts.
Human imaging was performed in the hamstring muscles of @number@ volunteers.
Human Immunodeficiency Virus- ( HIV- ) infected persons have a higher risk for acute myocardial infarction ( AMI ) than HIV-uninfected persons.
Human immunodeficiency virus ( HIV ) infection has become a chronic disease and @percent@ of patients will soon be older than @number@ years.
Human immunodeficiency virus ( HIV ) infection leads to reduced CD4T-cell counts and immune dysfunction.
Human induced pluripotent stem cell cardiomyocytes from a patient with a PKP2 deficit showed drastically reduced INa.
Human induced-pluripotent stem cells have become of interest due to their ability to supplement tissue engineered scaffolds.
Human-induced pluripotent stem cells ( iPSCs ) generated from human adult somatic cells through reprogramming hold great promises for future regenerative medicine.
Human intervention / clinical studies are needed to investigate the bioavailability and metabolism of the tannins and to substantiate the health benefits in humans.
Humanities research also will benefit from expanded understandings of aging and old age.
Human kinesin-like protein KIF14 , a microtubule motor protein , localizes at the midbody to finalize cytokinesis by interacting with CRIK.
Human leukocyte DNA telomere length ( LTL ) has been shown to shorten during aging.
Human lifespan has been increasing steadily during modern times , mainly due to medical advancements that combat infant mortality and various life-threatening diseases.
Human lifespan is determined greatly by genetic factors and some investigations have identified putative genes implicated in human longevity.
Human life span is mainly dependent on environmental and genetic factors.
Human life span , with or without modern medicine is around 85-95 years.
Human longevity is a complex phenotype influenced by genetic and environmental components.
Human longevity is a complex trait in which genetics , epigenetics , environmental and stochasticity differently contribute.
Human longevity is a multifactorial phenotype influenced by both genetic and environmental factors.
Human longevity is in part genetically determined , and the insulin / IGF-1 signal transduction ( IIS ) pathway has consistently been implicated.
Human lung tumor-associated CD8 + T lymphocytes also harbored senescent cells.
Human malignant mesothelioma ( MM ) is an aggressive cancer linked to asbestos and erionite exposure.
Human maximal lifespan is already substantially greater compared to that of closely related primate species.
Human memory is a highly heritable polygenic trait with complex inheritance patterns.
Human mesenchymal stem cell ( hMSC ) aging may lead to a reduced tissue regeneration capacity and a decline in physiological functions.
Human mesenchymal stem cells were obtained from bone marrow and differentiated into chondrocyte-like phenotype by three-dimensional culture , embedded in the same scaffold.
Human metabolic studies indicate that GI is related to patho-physiological responses after meals.
Human metapneumovirus ( hMPV ) is a common respiratory tract infection in children.
Human milk intakes were estimated by a model based on assumptions regarding satisfaction of weight-based daily energy needs by the combined diet.
Human mitochondrial DNA is small , about @number@.5kbp in length , and encodes only two rRNAs , @number@ tRNAs , and @number@ proteins.
Human molecular processes are influenced by physiological pathways as well as exogenous factors , which include the diet.
Human motor activity has a robust , intrinsic fractal structure with similar patterns from minutes to hours.
Human multiple myeloma B cell lines also lack Aldh1a1 expression ; however , ectopic Aldh1a1 expression rescued Rara and Znf423 expressions in these cells.
Human neurodegenerative maladies share two common key features : a mechanistic link to the accumulation and deposition of aberrantly aggregated proteins and late onset.
Human neurons are functional throughout a healthy adult lifespan , yet the mechanisms that maintain function and protect against neurodegenerative processes during aging are unknown.
Human neurophysiological studies have revealed that these changes are accompanied by a diminished ability to suppress visual cortical activity associated with task-irrelevant information.
Human NF155-based ELISA clearly distinguished between anti-NF155 antibody-positive and -negative sera.
Human non-hairy ( glabrous ) skin of the fingers , palms and soles wrinkles after prolonged exposure to water.
Human-nucleotide-excision repair ( NER ) deficiency leads to different developmental and segmental progeroid symptoms of which the pathogenesis is only partially understood.
Human obesity is associated with altered incretin secretion and elevated endocannabinoid levels.
Human Oc was found to circulate in over a dozen truncated forms with each of these displaying anywhere from 0-3 Gla residues.
Human organs obviously have color , but the underlying biologic processes that dictate the specific colors of organs and tissues are not completely understood.
Human ovarian cortex cubes were also treated with mTOR or / and PI3K stimulators in vitro.
Human oxoguanine glycosylase ( hOGG1 ) shows base excision activity for 8-oxo-dG in duplex DNA.
Human papillomavirus ( HPV ) can infect oral mucosa , causing asymptomatic infection or warty lesions.
Human plasma samples were from the Leiden Longevity Study comprising @number@ participants of different chronological and biological ages.
Human pluripotent stem cells ( hPSCs ) provide a model to study early neural development , model pathological processes , and develop therapeutics.
Human postmortem brain samples challenges neuroscientists because of the high level of autofluorescence caused by accumulation of lipofuscin pigment during aging , hindering systematic analyses.
Human premature ageing diseases are powerful model systems to identify and characterize cellular mechanisms that underpin physiological ageing.
Human primary myoblasts were treated with increasing concentrations of @number@ , 25 ( OH ) 2D3 for @number@ h.
Human prion diseases can be caused by mutations in the prion protein gene PRNP.
Human psoas major muscle undergoes normal aging changes with the atrophy of all three fibre types , whereas atrophy most profoundly affects type IIA fibres.
Human psychometric intelligence can predict a number of important social and academic outcomes.
Human relationships are crucial to our health and wellbeing - caring and support promote significantly better health outcomes.
Human reproductive fitness depends upon telomere chemistry.
Humans and horses share many of these age-related changes , with only a few differences.
Humans and other primates are distinct among placental mammals in having exceptionally slow rates of growth , reproduction , and aging.
Humans and several non-human primates possess cortical regions that are most sensitive to vocalizations produced by their own kind ( conspecifics ) .
Humans are exceptionally long-lived for mammals of their size.
Humans are living longer but morbidity has also increased ; threatening to create a serious global burden.
Humans are on average getting fatter with age , and obesity and aging interact each other to shorten lifetime and decrease life quality.
Humans are the longest living and slowest growing of all primates.
Humans are unique among primates in that women regularly outlive their reproductive period by decades.
Humans carrying the prevalent rs9939609 A allele of the fat mass and obesity-associated ( FTO ) gene are more susceptible to developing obesity than noncarries.
Human SEMAPHORIN 5A ( SEMA5A ) is an autism susceptibility gene ; however , its function in brain development is unknown.
Human senescence has been delayed by a decade , and people are reaching old age in better health.
Human senescence patterns-late onset of mortality increase , slow mortality acceleration , and exceptional longevity-are often described as unique in the animal world.
Human serum albumin ( HSA ) , transporting protein , is exposed during its life to numerous factors that cause its functions become impaired.
Human services were overall more available than health services.
Humans ' experience of emotion and comprehension of affective cues varies substantially across the lifespan.
Human sexual behavior also interacts with other pleasures , most notably social interaction and high arousal states.
Humans have a complex diet , which illustrates the need to elucidate the mechanisms of interaction between these bioactive compounds in combination.
Humans have a tendency to perceive motion even in static images that simply \ "imply \ " movement.
Humans have unique abilities in using tools.
Humans in modern societies typically consume food at least three times daily , while laboratory animals are fed ad libitum.
Human sirtuin @number@ is a member of the histone deacetylase family and is involved in cellular aging , tumourigenesis and cellular metabolism.
Human skin fibroblasts were cultured and irradiated with different doses of UVA , thus creating a photoaging model.
Human skin is a primary target of oxidative stress from reactive oxygen species ( ROS ) generated from both extrinsic and intrinsic sources.
Human skin is continuously exposed to UV light.
Human skin is largely composed of a collagen-rich connective tissue , which provides structural and functional support.
Human skin structures stained positively for angiomotin or endostatin were studied by indirect immunohistochemical method.
Humans share implicit preferences for cross-modal mappings ( e.g. , low pitch sounds are preferentially paired with darker colours ) .
Humans spend approximately one-third of their lives asleep.
Human studies are reviewed concerning whether \ "aging \ "-related mechanisms contribute to Alzheimer's disease ( AD ) pathogenesis.
Human studies have revealed only a weak link between ω-3 PUFA status and cognitive aging , whereas interventional studies have yet to confirm it.
Human studies have shown that some oral antidiabetic medications can improve cognition in patients with MCI and AD.
Human studies investigating the suggested associations while controlling for potential confounding factors are lacking.
Human studies on how aging effects wound healing will always be the gold standard , but studies have ethical and practical hurdles.
Human studies using non-invasive magnetic resonance imaging ( MRI ) have shown inconsistencies in volume changes , and have also shown an age effect.
Human studies varied considerably in design , quality , and findings ; none investigated the effects of high iron intake in neonates / infants.
Humans used an alternative , \ "democratic \ " pathway , namely technical progress facilitating adaptation to the changing environmental conditions.
Humans utilize facial appearance , gender , expression , aging pattern , and other ancillary information to recognize individuals.
Humans with germline SHP-2 mutations develop Noonan syndrome or LEOPARD syndrome , which are characterized by cardiovascular , neurological and skeletal abnormalities.
Human TDP-43 represents the main component of neuronal inclusions found in patients with neurodegenerative diseases , especially frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Human telomerase is constituted by two components : the telomerase reverse transcriptase ( TERT ) and the telomerase RNA component ( TERC ) .
Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure , known as the G-quadruplex.
Human tendon mechanical properties are modified with loading.
Human TH has several isoforms produced by alternative mRNA splicing , which may affect activation by phosphorylation of serine residues in the N-terminus of TH.
Human traffic in general caused slightly reduced and more evenly distributed As concentrations on the wood surfaces.
Human umbilical cord mesenchymal stromal cells ( hUC-MSCs ) of Wharton's jelly origin undergo adipogenic , osteogenic , and chondrogenic differentiation in vitro.
Human values and social issues shape visions on dwelling and care for older people , a growing number of whom live in residential care facilities.
Human ventral temporal cortex ( VTC ) plays a pivotal role in high-level vision.
Human vision , however , develops well beyond the first few years.
Human vision quality is influenced by ocular aberrations , including astigmatism and higher-order aberrations ( HOAs ) , in combination with other optical factors.
Human VSMC ( HuVSMC ) from donors ranging in age from @number@ to @number@ ( n = @number@ ) were isolated and cultured.
Human walking is highly adaptable , which allows us to walk under different circumstances.
Human γ-crystallin ( HGC ) , a water soluble protein present in the lens is known to aggregate with aging.
Hum Brain Mapp.
Hum Brain Mapp 38 : 1588-1603 , @number@ © @number@ Wiley Periodicals , Inc.
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Humoral autoreactivity to human Hb was demonstrated in the sera of systemic lupus erythematosus ( SLE ) , leishmania and malaria patients.
Huntchinson-Gilford Syndrome ( Progeria ) is a rare autosomal dominant disease characterized by premature aging.
Huntington disease ( HD ) is an inherited neurodegenerative disease caused by a CAG expansion in the HTT gene.
Huntington disease ( HD ) prevalence shows geographic variability and has been recently updated by taking into account the mutation diagnostic test.
Huntington's disease ( HD ) is the most common inherited neurodegenerative disease and is characterized by uncontrolled excessive motor movements and cognitive and emotional deficits.
HuR influences gene expression programs and hence cellular phenotypes by binding to hundreds of coding and noncoding linear RNAs.
HuR interacted with the same Myc @number@'-UTR element , and increasing the levels of HuR decreased CELF1 binding to Myc mRNA.
HuR promotes myogenesis by stabilizing the MyoD , myogenin and p21 mRNAs during the fusion of muscle cells to form myotubes.
Hurricane Sandy stressors predicted increased odds of depression , including storm injury , post-storm crime , and the total count of stressors.
Husbands ' and wives ' own reports of their attitudes toward aging were significantly correlated with their own and their spouses ' psychological well-being.
Husbands had increased blood pressure when wives reported greater stress , and this link was exacerbated by negative spousal relationship quality.
Husbands were more likely to describe partners ' suffering as interpersonal.
Husbands who gave more support to their living parent ( s ) than their wives reported lower marital satisfaction.
Hutchinson-Gilford progeria syndrome ( HGPS ) constitutes a genetic disease wherein an aging phenotype manifests in childhood.
Hutchinson-Gilford progeria syndrome ( HGPS ) is a genetic disease in which children develop pathologies associated with old age.
Hutchinson-Gilford progeria syndrome ( HGPS ) is a rare , deadly laminopathy.
Hutchinson-Gilford progeria syndrome ( HGPS ) is a rare segmental premature aging disorder that affects bone and body composition , among other tissues.
Hutchinson-Gilford progeria syndrome ( HGPS ) is a rare , uniformly fatal , premature aging disease with distinct dermatologic features.
Hutchinson-Gilford progeria syndrome ( HGPS ) is caused by a mutation in LMNA that produces an aberrant lamin A protein , progerin.
Hutchinson-Gilford progeria syndrome ( HGPS , OMIM @number@ ) is a rare multisystem childhood premature aging disorder linked to mutations in the LMNA gene.
Hutchinson-Gilford progeria syndrome ( HGPS ) was the first premature aging syndrome linked to LMNA mutation and its molecular bases have been deeply investigated.
Hutchinson-Gilford progeria syndrome is a rare congenital disease characterized by premature aging in children.
Hutchinson-Gilford progeria syndrome is a rare genetic disorder characterized by premature aging of the skin , bones , heart , and blood vessels.
HUVECs were cultured and stimulated by TNF-α with or without DTD serum ( @number@ @number@ and @percent@ ) .
HUVEC were stimulated with interleukin 1-β and VEGF , respectively.
Hu-Yi-Neng protected SH-SY5Y cells from oxidative stress may via the increase in mRNA expression of heme oxygenase-1 ( HO-1 ) , an antioxidant enzyme.
HVI may be more effective in improving outcomes of chronic AT than PRP in the short term.
HVLT total recall score was consistently the strongest predictor of each functional outcome.
HVs were obtained using automated segmentation software.
Hyaluronan , as most macromolecules of the extracellular matrix , are produced by the differentiated mesenchymal cells.
Hyaluronan ( HA ) , an abundant polysaccharide found in human bodies , plays a role in the mesenchymal stem cells ( MSCs ) maintenance.
Hyaluronic acid filler can be used for attenuating the nasojugal sulcus but irregular lumpness and overcorrection are common adverse reactions.
Hyaluronic acid ( HA ) , a major component of the dermal matrix , decreases after chronic UVB exposure.
Hyaluronic acid ( HA ) fillers have become the material of choice for soft-tissue augmentation.
Hyaluronic acid ( HA ) is biocompatible , easy to use and reversible.
Hyaluronic acid has a predominant and unchallenged place among fillers , well ahead of poly-L-lactic acid or calcium hydroxyapatite.
Hyaluronic acid is currently the most widely used dermal filler for the treatment of facial wrinkles.
Hybrid fibers containing IIB / IIB ' MHC decreased in the old vervets.
Hybrid multilevel models are used to analyze the change in parent-adult child contact over two waves of the National Survey of Families and Households.
Hybrid repair of a thoracoabdominal aortic aneurysm is a good option for elderly , high-risk patients because the early and late results are acceptable.
Hybrid TEVAR was performed in @number@ cases of aortic aneurysm and chronic dissection of the thoracoabdominal field between @number@ and @number@
Hybrid training was performed on @number@ elderly subjects.
Hydration , physical activity and exercise are key factors for enhancing human health.
Hydration status was assessed in the morning , before and immediately after practice.
Hydrocephalus is a neurological disorder whose clinical symptoms and treatment outcome are correlated with patient age.
Hydrogen peroxide ( H2O2 ) and paraquat were used to mimic the effects of damage caused by acute oxidative stress.
Hydrogen peroxide ( H2O2 ) was used to mimic oxidative stress damage to fruit flies and the survival time was recorded.
Hydrogen peroxide may cause methemoglobinemia in patients with catalase deficiency.
Hydrogen peroxide , the nonradical 2-electron reduction product of oxygen , is a normal aerobic metabolite occurring at about @number@ nm intracellular concentration.
Hydrogen peroxide was - and is still - considered toxic for a wide range of living organisms.
Hydrolyzable tannins are among the major bioactive components of the fruits.
Hydrophilic fillers were echo visible , whereas tissue-generating fillers , permanent and resorbable , could be detected according to their tissue-generating reaction within the tissue.
Hydrophobic environmental neurotoxicants , such as @number@ , 3-dinitrobenzene and α-chlorohydrin , cause regionally specific spongiform lesions mimicking energy deprivation syndromes.
Hydroxylamine derivatives act as co-inducers of heat-shock proteins ( HSPs ) and can enhance HSP expression in diseased cells , without significant adverse effects.
Hydroxyl radical is a short-lived radical which is considered very aggressive due to its high reactivity toward biological molecules.
Hydroxyproline assay was performed on each group's supernatant to quantify the collagen extraction amounts of each group per time period.
Hyoid fractures are variably reported to occur in manual strangulation and during hanging.
Hyoid variants were also documented.
Hyperactive Ras signaling has strong oncogenic effects causing several different forms of cancer.
Hyperactivity and its compensatory mechanisms may causally contribute to synaptic and cognitive deficits in Alzheimer's disease ( AD ) .
Hyperactivity is frequently induced by mutations within Ras itself , which account for up to @percent@ of all human cancers.
Hyperactivity symptoms were associated with combination therapy of this type ( OR @number@ @percent@ Cl @number@.36-2.34 ) .
Hyperacusis and tinnitus are potentially devastating conditions that are still incurable.
Hyperaminoacidemia during a simulated fed steady-state clamp compensates for this resistance.
Hyper- and normotensive subjects did not differ in their CSF biomarkers , hippocampal volumes ( HipVs ) , or memory scores at baseline.
Hyperbaric oxygen is supported with marginal strength only.
Hypercapnia increased oxy-haemoglobin and decreased deoxy-haemoglobin concentrations in both groups.
Hypercapnia was induced by a breath-hold , hypocapnia by hyperventilation.
Hypercholesterolaemia was defined as low-density lipoprotein cholesterol ( LDL-C ) in excess of the recommended CVD risk category target and / or on lipid-lowering medication.
Hypercholesterolemia was defined by total cholesterol of > 200mg / dl or current use of lipid-lowering drugs.
Hypercholesterolemia , which is well known one of the important risk factor for cardiovascular disease , is more prevalence in women than men.
Hyperconnectivity could be an adaptive ( compensatory ) mechanism by recruiting additional resources to maintain normal cognitive performance.
Hyperfiltration , infections and Type @number@ diabetes cause glomerular and tubular fibrosis , leading to further reductions in nephron number.
Hyperglycaemia induces increased peripheral utilization of insulin , resulting in reduced insulin transport into the brain.
Hyperglycemia and hyperinsulinemia accelerate both aging and cancer.
Hyperglycemia and hypertriglyceridemia cause cognitive impairment.
Hyperglycemia in diabetes results in the glycation of long-lived proteins.
Hyperglycemia is a cause of cognitive deterioration , low intelligent quotient , neurodegeneration , brain aging , brain atrophy and dementia.
Hyperglycemic clamps confirmed an increase in insulin sensitivity with normal β-cell function in 12- and 18-week-old ΔF508 mutants.
Hyperglycemic crises include diabetic ketoacidosis ( DKA ) , hyperosmolar hyperglycemic syndrome ( HHS ) , and lactic acidosis ( LA ) .
[ Hypericaceae ( Clusiaceae ) ] is an Amazonian plant traditionally used by indigenous population to treat dermatosis and inflammatory processes of the skin.
Hyperinsulinaemia as well as complete lack of insulin result in increased τ phosphorylation , leading to an imbalance of insulin-regulated τ kinases and phosphatates.
Hyperleptinemia , on the other hand , may promote the development of age-related abnormalities.
Hyperlipidemia , diabetes , hypertension , smoking and aging are important risk factors for the dysfunction of endothelial cells ( EC ) .
Hypermethylated DMRs were more likely to overlap with CpG islands and shores.
Hypermobility decreased from @number@ to @percent@ and pes planus decreased from @number@ to @percent@.
Hypernatremia in the geriatric population is a common disorder associated with significant morbidity and mortality.
Hyper @number@ ; 42 : 1206. ] .
Hyperopia was more common in females than males although the difference was not statistically significant.
HyperPATH cohort analyses revealed risk allele carriers vs noncarriers had increased aldosterone / renin ratios.
Hyperphosphatemia , and the homeostatic mechanisms controlling phosphate metabolism , have received particular attention over the past decade.
Hyperphosphatemia is pivotal in some complications secondary to kidney dysfunction.
Hyperphosphorylation of tau is a key factor in the generation of NFTs.
Hyperpigmentation ( @percent@ ) , milia ( @percent@ ) , acne breakout ( @percent@ ) , and transient ectropion ( @percent@ ) were less common.
Hyperpigmentation was seen in two subjects.
Hyperprolinemic patients have a significantly later age of first psychiatric hospitalization , suggestive of later onset , and hospital stays @percent@ longer than non-hyperprolinemic subjects.
Hyperprolinemic patients were significantly older at their first hospitalization ( p = 0.015 following correction for multiple testing ) .
Hypertension and aging are characterized by vascular remodelling and stiffness as well as endothelial dysfunction.
Hypertension and benign prostatic hyperplasia ( BPH ) are common disorders of aging men.
Hypertension and CVD deaths were positively associated with higher particulate matter levels.
Hypertension and diabetes become more prevalent with age and should be timely diagnosed and treated.
Hypertension and diabetes mellitus were the most common comorbidities.
Hypertension and increased vascular stiffness are viewed as inevitable parts of aging.
Hypertension and ischemic cardiomyopathy are the most frequent aetiologies , but diabetes plays an increasing role.
Hypertension and nicotine usage have also been suggested as risk factors.
Hypertension and smoking are related with oxidative stress ( OS ) , which in turn reports on cellular aging.
Hypertension , a significant factor in the development of cerebrovascular disorders , heart disease and renal failure , is a common disorder worldwide.
Hypertension , based on the doctor's diagnosis , was obtained through face-to-face interview.
Hypertension can potentially damage the hippocampus through ischaemia caused by atherosclerosis and cerebral amyloid angiopathy.
Hypertension control in diabetic patients is a challenge.
Hypertension grade @number@ @number@ and @number@ was observed in @percent@ , @percent@ , and @percent@ of patients , respectively.
Hypertension has a direct negative effect on the cerebrovascular circulation independent of white matter hyperintensities and stroke that is comparable to that seen with stroke.
Hypertension ( history or systolic blood pressure > 140 mm Hg ) was associated with slower decline in memory.
Hypertension ( HTN ) is a chronic medical condition that commonly affects the aging population worldwide.
Hypertension ( HTN ) is the most common disease found in patients in primary care [ JNC-7 Guidelines.
Hypertension , hypercholesterolemia , or aging did not exert a further impairment of endothelial relaxation among ED patients.
Hypertension , hyperglycemia and hyperlipidemia remained as risk factors of overweight and obesity.
Hypertension , hyperlipidemia and metabolic syndrome are highly prevalent.
Hypertension , hyperlipidemia and obesity were more frequent in women , COPD , ischemic heart disease and renal failure in men.
Hypertension ( i.e. , outcome ) was identified by self-report.
Hypertension increased the rate of all fractures by @percent@ after adjustment for covariates [ aIRR : @number@ ( @number@ @number@ ) ] .
Hypertension in pregnancy is a frequent disorder that includes a spectrum of conditions.
Hypertension in pregnancy is associated with an increased risk of future microalbuminuria.
Hypertension in the elderly can be attributed to numerous structural and functional changes to the vasculature that develop with advancing age.
Hypertension in the elderly patients represents a management dilemma to geriatric and cardiovascular specialists and other practitioners.
Hypertension is a common problem in the elderly.
Hypertension is a leading cause of global disease , mortality , and disability.
Hypertension is a major health problem with great consequences for public health.
Hypertension is a major risk factor for cardiovascular disease.
Hypertension is a major risk factor for cardiovascular events , including ischemic stroke and hemorrhagic stroke.
Hypertension is a major risk factor for CV disease and mortality.
Hypertension is a risk factor for WM lesion formation.
Hypertension is a significant risk factor for cardiovascular morbidity and mortality in people older than @number@ years.
Hypertension is associated with development of white matter hyperintensities ( WMH ) in the brain , which are risk factors for mild cognitive impairment.
Hypertension is associated with microvascular and macrovascular brain injury but its direct influence on the cerebral circulation is not fully clear.
Hypertension is common in the elderly , and isolated systolic hypertension is responsible for the majority of hypertension in this population.
Hypertension is common in the older populations of IMIAS.
Hypertension is influenced by traditional risk factors and duration of HIV infection but not antiretroviral treatment.
Hypertension is often presented as an accelerated aging of the heart and arteries.
Hypertension is one of the most prevalent chronic diseases among older adults , but rates of blood pressure control are low.
Hypertension is the leading risk factor for cardiovascular disease and one of the major health concerns worldwide.
Hypertension is the most common condition that leads to multiple organ complications , disability , and premature death.
Hypertension is the most common disease , followed by coronary artery disease , diabetes and chronic obstructive pulmonary disease.
Hypertension ( @number@ % ) and diabetes mellitus ( @number@ % ) were the two most common underlying diseases.
Hypertension ( OR = @number@ ) was positively associated with overweight.
Hypertension , osteoporosis and vascular calcification are major diseases in the recent aging society and may share the same backgrounds genetically and environmentally.
Hypertension patients were more likely to suffer from obesity , diabetes , dyslipidemia , and risk factors for cardiovascular diseases , but not osteoporosis.
Hypertension prevalence ranged from @percent@ in Saint-Hyacinthe to @percent@ in Tirana.
Hypertension prevalence was @percent@ in @number@ to @number@ and @percent@ in @number@ to @number@
Hypertension prevalence was @percent@ in older adults ( 50-plus years ) and @percent@ in younger adults ( 18-49 years ) .
Hypertension was BP ≥ 140 / 90mmHg , awareness and / or use of antihypertensive treatment.
Hypertension was defined as a systolic blood pressure ≥140 mm Hg , or a diastolic blood pressure ≥90 mm Hg , or receiving antihypertensive medications.
Hypertension was diagnosed in 8 / 78 ELBW and 2 / 38 of the control children ( p = @number@ ) .
Hypertension was evaluated through both office and ambulatory blood pressure ( BP ) measurements.
Hypertension was independently associated with risk of cardiac death ( RR , @number@ @percent@ CI , @number@ to @number@ ) .
Hypertension was insignificant and did not change the direction or size of the effect of the multi-morbidity measure substantially.
Hypertension was lower in the mentally ill group ( p < 0.0001 ) .
Hypertension was present in @number@ subjects and absent in @number@ subjects.
Hypertension was the cardiovascular risk factor ( CVRF ) more prevalent in both ischemic and hemorrhagic strokes , followed by dyslipidemia and diabetes mellitus.
Hypertension was the most common chronic condition.
Hypertension was the most common risk factor ( @percent@ ) among the stroke survivors , followed by diabetes ( @percent@ ) .
Hypertension was the most frequently reported comorbidity ( @percent@ ) .
Hypertension was the most prevalent comorbidity.
Hypertensive disorder can cause cardiac deformities.
Hypertensive donors were more likely to have an abnormal number of globally sclerotic glomeruli ( OR = @number@ P = @number@ ) .
Hypertensive nephrosclerosis is mildly symptomatic , but the prognosis is never benign , due to cardiovascular and renal burden.
Hypertensive nephrosclerosis was long considered a major cause of end-stage renal failure ( ESRD ) .
Hypertensive participants in both samples had more WMH than normotensive participants.
Hypertensives and normotensives showed negligible differences in plasma concentrations of steroids.
Hypertensives with cardio-cerebral vascular diseases exerted further influence on active life expectancy , particularly among population of virile senility.
Hypertriglyceridaemia was associated with protease inhibitor-based highly active antiretroviral therapy.
Hypertriglyceridemia ( HTG ) is a risk factor for atherosclerotic cardiovascular disease ( CVD ) .
Hypertriglyceridemic AP increased at a faster rate than alcoholic AP.
Hypertrophy of the ligamentum flavum ( LF ) can reduce the diameter of the spinal canal posteriorly.
Hyperuricemia was defined as serum uric acid ( SUA ) > 420 μmol / L for men , > 360 μmol / L for women.
Hypnotic drugs should be used carefully to avoid causing delirium , amnesia , and falls.
Hypnotics and opiates , have also subcortical primary targets , and the EEG performances in the evaluation or prediction of nociception are poor.
Hypoalbuminaemia may be a reasonable predictor of shorter-term mortality in this patient subgroup.
Hypo- and hypernatremia can be life threatening and should be diagnosed and treated promptly , following current practice guidelines.
Hypo- and hyperpigmentation were observed over areas of sclerodermoid change.
Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis.
Hypocitraturia and hypercalciuria are risk factors for calcium stone disease.
Hypocontractility was more likely in women @number@ years old or older ( OR @number@ @percent@ CI @number@ @number@ ) .
Hypofractionation is often preferred because of shorter procedure.
Hypoglossal motoneurons ( HMs ) innervate tongue muscles and are critical in maintaining patency of the upper airway during respiration.
Hypoglycaemia was reported as ' frequent ' in @percent@ of NHs.
Hypoglycemia and it's consequences are important considerations when planning the treatment of diabetes.
Hypoglycemia episodes were identified by medical or biological records.
Hypoglycemia was noticed in 42 / 236 ( @percent@ ) , in all categories of glycemic control.
Hypogonadal patients in whom PDE5 inhibitor failed could be rescued by the administration of testosterone.
Hypogonadism alone is a not risk factor for severe ED.
Hypogonadism and / or hyperestrogenism could act as a third hit , favoring the maintenance of this inflammatory state.
Hypogonadism and symptomatic androgen deficiency were negatively and significantly related to diabetes , monthly income and age ( P value < 0.005 ) .
Hypogonadism in males is associated with increased atherosclerotic disease.
Hypogonadism is estimated to affect about @number@ million American men , including both aged and young.
Hypogonadism is frequently observed in subjects with type @number@ DM ( T2DM ) and especially those complaining of ED.
Hypogonadism may arise from testicular disease ( primary hypogonadism ) or dysfunction of the hypothalamic-pituitary unit ( secondary hypogonadism ) .
Hypogonadism was defined as total testosterone < 3 ng / ml and calculated free testosterone < 5 ng / dl.
Hypogonadism was defined by the presence of serum testosterone levels lower than @number@ ng / dl.
Hypogonadism was seen more prevalent in patients with MetS ( @percent@ vs. @percent@ , p = @number@ ) .
Hypohydration level , TT time and fluid intake were @number@ ± @percent@ BW , @number@ ± @number@ min and @number@ ± @number@ ml , respectively.
Hypokalaemia and creatinine increase were significantly more frequent with L-AMB.
Hypometabolic volumes were similar in the @number@ groups.
Hypomobility under the influence of external factors is one of the leading syndromes potentiating aggravation processes senile asthenia.
Hyponatraemia , hypokalaemia , hypomagnesemia lead to heart rhythm disturbances and risk of glycoside intoxication.
Hyponatremia is the most common electrolyte disturbance.
Hyponatremia is underdiagnosed and , more seriously , undertreated , despite numerous studies demonstrating its devastating effects on hospital admissions.
Hypoperfusion in the anterior cingulate cortex during REM sleep allowed better classification than hypoperfusion found in wakefulness ( @number@ vs @percent@ ) .
Hypoperfusion occurs early in Alzheimer's disease , inducing white matter lesions and correlating with dementia.
Hypophysectomized patients may represent a good model to assess both pharmacodynamics and effective dose of LH and hCG in the male.
Hypo-responsiveness to growth factors is a fundamental feature of cellular senescence.
Hyposalivation ( HS ) affects aging individuals by causing pain and discomfort in the oral cavity.
Hypothalamic corticotropin-releasing factor ( CRF ) lays downstream to catabolic melanocortins and at least partly mediates their catabolic effects.
Hypothalamic functions that affect feeding behavior , endocrine function , and circadian rhythmicity are all regulated by SIRT1.
Hypothalamic hypogonadism can be caused by stress , depression , anorexia or excessive exercise.
Hypothalamic hypogonadism is less clinically evident in men and the diagnosis is difficult to establish.
Hypothalamic releasing and inhibiting hormones are major neuroendocrine regulators of human body metabolism being driven directly to the anterior pituitary gland via hypothalamic-hypophyseal portal veins.
Hypothalami of @number@ control female subjects were categorised into three periods : infant / prepubertal , adult and elderly.
Hypothermia avoidance consists in a concomitant decrease in heat dissipation and increase in heat production.
Hypotheses for these unexpected results are suggested.
Hypotheses seeking to explain ontogenescence include those based on kin selection , the acquisition of robustness , heterogeneous frailties and life-history optimization.
Hypotheses testing procedures that incorporate the constraints are developed.
Hypotheses were supported.
HYPOTHESIS : Arthroplasty and internal fixation produce similar outcomes in non-displaced fractures of patients older than @number@ years with PFFs.
HYPOTHESIS : Cardiac resynchronization therapy improves libido and ED.
HYPOTHESIS : Most golfers successfully return to sport after lumbar fusion surgery.
( Hypothesis @number@ ) In addition , baseline depressive symptoms as predictors for longitudinal change in lipid profile trajectory were tested.
( Hypothesis @number@ ) Mixed-effects regression analyses stratified by sex was used.
HYPOTHESIS / PURPOSE : Reportedly , these effects can be delayed by mild genetic or pharmacological activation of the main modules of the proteostasis network.
HYPOTHESIS / PURPOSE : We aimed to measure overall and disease-specific mortality of French female and male Olympians compared with the French general population.
HYPOTHESIS : Risk of stroke in hyperthyroidism-related AF is the same as nonhyperthyroid counterparts.
HYPOTHESIS : Sleep disturbance is prevalent in patients with a symptomatic rotator cuff tear , and sleep disturbance improves after arthroscopic rotator cuff repair.
HYPOTHESIS : The coexistence of multiple cardiovascular diseases is an independent predictor of the 30-day mortality of hospitalized patients with CHF.
HYPOTHESIS : There are important differences in the clinical characteristics and outcome between elderly MI patients selected for invasive or conservative treatment strategy.
Hypothetical production costs were estimated to illustrate differences had PEPFAR support not been available.
Hypothyroidism , normal pressure hydrocephalus , and depression also impair cognitive functions , and therefore these pathological conditions are easily mistaken for dementia.
Hypotonicity-induced cytosolic Ca²⁺ ( [ Ca²⁺ ] ( i ) ) rise in iPSC-ECs was measured by confocal microscopy.
Hypovitaminosis D was considered as < @number@ ng / ml and deficiency < @number@ ng / ml.
Hypoxemia is common is obesity and correlates well with FRC , as well as with measures of abdominal obesity.
Hypoxia and extracellular acidosis are pathophysiological hallmarks of aggressive solid tumors.
Hypoxia can affect the expression of transcription factors , classical receptor tyrosine kinase factors , non-classical G-protein coupled factors , catecholamines , and purines.
Hypoxia can induce functional and structural vascular remodeling by changing the expression of trophic factors to promote homeostasis.
Hypoxia caused by microvascular changes and disturbed capillary flows could stimulate this build-up of AD-specific proteins in the brain.
Hypoxia increases both active and repressive histone methylation levels via decreased activity of histone demethylases.
Hypoxia-inducible factor-1 directly regulated TrkB expression , and , in turn , TrkB activated Akt signaling in metastatic lung cancer cells.
Hypoxia-inducible factor @number@ ( HIF-1 ) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species.
Hypoxia in the nervous tissue induces oxidative stress.
Hypoxia may also activate mitophagy to selectively remove damaged or unwanted mitochondria for both mitochondrial quantity and quality control.
Hypoxia undoubtedly induces reduced energy production via decreased mitochondrial metabolic activity or altered hypoxia-inducible factor-1- and peroxisome proliferator-activated receptor gamma coactivator 1-dependent mitochondrial biogenesis.
Hypoxic condition induced HIF-1α protein level in PC-3 cells in a time-dependent manner , and treatment with HS-1793 markedly decreased HIF-1α expression levels.
Hypoxic conditioning was investigated as a form of angiogenic stimulation.
Hypoxic injury and aging affected the interaction between the EPO and ET systems.
Hypoxic pulmonary vasoconstriction ( HPV ) is an important physiological response that optimizes the ventilation / perfusion ratio.
HyQue identified @number@ novel but well-supported candidate aging-related genes for further experimental validation.
Hysterectomy is not required in most patients with procidentia.
Hysteroscopic septoplasty was performed in the early follicular phase.
HZ almost always causes pain , and post-herpetic neuralgia is its most common complication.
HZ epidemiology in Asia-Pacific is similar to elsewhere ; incidence rises with age and peaks at around @number@ years - lifetime risk is approximately one-third.
I405V and Taq1B polymorphisms were not associated with the risk of carotid atherosclerosis and longevity.
IA caused by azole-resistant A. fumigatus ( ARAF ) shows an exceedingly high mortality.
I also indicate how new insights into skin biology , disease , and aging may come from unexpected sources.
I appeal to the house of Dermatology to embrace this concept of Generational Dermatology as preventive medicine for the evolving aging patient.
I argue for a framework that theorizes the intersections of relations of gender inequality with those of age.
I argue that overpopulation is highly unlikely to result from technologies that slow ageing.
I argue that phenomenological studies of existential responses to illness are necessary in order to understand cultural sources of unmet expectations resulting from chronic conditions.
I argue that these two lines of transformation , kinship and citizenship , result in new forms of gender and intergenerational inequalities.
I argue that this causes higher rates of turnover within their personal social networks.
I assessed perceptions and fears around aging , preparation for later life , and end-of-life as well as numerous demographic and psycho-social variables.
Iatrogenic disease can have a great psychomotor impact and important social consequences.
Iba1 immunopositive microglia counts increased significantly in frontal cortex containing plaques in sAD.
IBD is a chronic disorder with disease onset ranging from early childhood to beyond the sixth decade of life.
I believe that case studies are an instructional tool that offers essential points for acquiring practical knowledge.
I believe that there is no \ "one-size-fits-all \ " solution in this area , but two ideas come to my mind.
I believe that the restriction of cell proliferation in an aging multicellular organism is not a consequence of implementing a special program.
I believe the specialty will increasingly focus on how the skin can optimally perform for a longer period.
Ibogaine also increased SOD1 activity in erythrocytes at both doses applied here.
Ibrutinib is generally well tolerated , although current follow-up remains short and patients of advanced age are more likely to discontinue treatment for toxicity.
IBS clusters in families but it is unknown whether this is explained by a common environment , genes , or both.
IBS is characterized by abdominal pain and altered bowel habits in the absence of specific organic pathology.
IBS patients had a higher risk of developing ED compared with non-IBS subjects.
IBS patients with a history of ED before the index date or with incomplete demographic information were excluded.
Ibuprofen pediatric suspension ( @number@ mg / 5 mL ) was formulated with grewia gum ( @percent@ w / v ) as the suspending agent.
IC aims to promote timely discharge from hospital , prevent unnecessary hospital admissions and reduce the need for long-term residential care by optimizing functional independence.
ICAM-1 positively correlated with these AD pathology measures.
ICAM-1 , VCAM-1 and E-selectin were significantly reduced at crossover and further decreased at study end.
IC A strategy for the preservation of intrarenal vasculature conditions remains obscure in middle-aged and older individuals without the renal disease.
ICC size was only affected in the myenteric plexus in the colon.
ICC-type measurements from G-Theory of both the IMF and the fatigue slopes ranged from @number@ to @number@
ICC values were > or = @number@ and SEM values ( expressed as percentage of the mean ) were < or = @percent@.
ICER negatively transcriptional regulators of cAMP activators such as CREM and CREB.
Ichthyosis is also common in several types of CDG.
ICH volume was measured by ABC / 2 or a semiautomated planimetric method.
I close the paper by discussing the implications for aging research.
ICL predisposes patients to severe opportunistic infections and frequently leads to poor vaccination effectiveness.
IC may also be utilized in the diagnosis of other ocular diseases , such as keratoconus and thyroid orbitopathy.
ICNs project for several millimeters within the corneal epithelium without Schwann cell support.
I conclude by considering the utility of cognitive support work as a concept within dementia caregiving.
I conclude with implications for practice in the helping professions and recommendations for future research.
I conducted face-to-face , semistructured interviews with @number@ dyads of matched elders and their children ( N = @number@ ) .
ICRs were compared among groups to analyze age-related changes and the relation between degenerative changes and ICR location.
ICT access was positively associated with all types of women's social engagement , but only with men's informal social participation.
ICT offers a variety of opportunities for the treatment and prevention of frailty and functional decline.
ICTs should encourage active ageing and , in the case of health technologies , new models of care.
ICT use was unrelated to depressive symptoms or well-being.
ICU elderly patients at malnutrition risk will have higher complication and infection rates , longer duration of ICU stay , and increased mortality.
ICURs for 60- to 69-year-old LDASA users were €13 , 264 / QALY and €64 , 121 / QALY for patients @number@ years and older.
ICV showed homogeneous variances across scanners except for Siemens scanners at @number@ Tesla ( p = @number@ ) .
IDA includes mRNA expression , somatic mutation , copy number variation and phosphorylation data of ARS / AIMPs and their interacting proteins in various cancers.
ID and aneurysms of the PCoA were found in 6 / 267 or @percent@ and 3 / 267 or @percent@ of adults , respectively.
IDD , deemed to be a kind of autoimmune diseases , may involve IL23A in the pathogenesis.
Ideal BMI was less frequent at ages @number@ to @number@ years than at ages @number@ to @number@ years ( @percent@ versus @percent@ ) .
Ideal free distribution theory predicts that individuals distribute themselves so fitness is equal among patches.
Ideally , all healthcare providers involved in family planning , pregnancy and child birth should recommend cocooning.
Ideally , screening decisions would consider an older woman's life expectancy , breast cancer risk , and her values and preferences.
Ideally , technology will make the task easier , more efficient , safer , or perhaps more pleasurable.
Ideally , the full adult age spectrum should be included to assess brain imaging findings associated with typical aging.
Ideal oncology drugs would be curative after a short treatment course if they could eliminate epithelium-originated carcinomas at their non-invasive , pre-malignant stages.
\ "Ideal UHC \ " is to ensure that all people could obtain the health services they need without suffering any financial hardship.
Ideas of loss of self and loss of life feature strongly in dementia and have the potential to profoundly affect a person's spirituality.
Identification and treatment of vulnerable elderly patients with OAB is important , because intervention may limit functional deterioration.
Identification for dementia was based on consensus manuals.
Identification of anatomical variation of the caudate tail may prevent potential diagnostic pitfalls , especially with respect to subependymal heterotopia.
Identification of cognitive and brain markers associated with long-term growth of children's basic numerical computation abilities is therefore of utmost importance.
Identification of comorbid inflammatory diseases that synergistically might heighten this risk would provide further insight into therapeutic approaches to prevent frailty.
Identification of conserved pathways regulating longevity holds out the eventual possibility of pharmacologic health- and lifespan extension in humans.
Identification of decision-making impairment in suicidal elders may help with designing effective interventions.
Identification of dementia is particularly difficult in its early phases when family members and physicians often incorrectly attribute the patient's symptoms to normal aging.
Identification of factors associated with poor self-rated health in stroke survivors has received little attention compared to that in other older individuals.
Identification of factors that are independently associated with food intake will help to develop effective interventions that support food intake.
Identification of family members at risk for postloss grief during the preloss period may help guide interventions aimed at lessening postloss grief.
Identification of functional variant ( s ) in this region likely awaits deep sequencing.
Identification of genes associated with brain aging should markedly improve our understanding of the biological processes that govern normal age-related decline.
Identification of GPER as a third ER has introduced further complexity to the system.
Identification of imaging biomarkers for schizophrenia is an important but still challenging problem.
Identification of individuals at high fracture risk to provide early treatment in developing countries with limited resources remains a challenge.
Identification of inflammatory markers and their association with characteristics of depression is essential with the aim to improve diagnosis and therapeutic approaches.
Identification of mechanisms that influence a healthy lifespan is of economic , medical and social importance in our ' ageing ' world.
Identification of modifiable risk factors for MCR will improve identification of high-risk individuals and help develop interventions to prevent cognitive decline in aging.
Identification of more metabolically stable ( @number@ ) F-hydroxyquinolines that can be readily accessed by the radiochemical strategy presented herein is underway.
Identification of oxidized and reduced phosphatase and tensin homolog ( PTEN ) was analyzed through N-ethylmaleimide alkylation , nonreducing electrophoresis.
Identification of pain and need for pain relief was ill defined and poorly understood.
Identification of patient profiles may lead to more personalized healthcare , with more targeted treatment for osteoarthritis.
Identification of predictors of dizziness may provide new leads for the management of dizziness in older patients.
Identification of risk factors in patients with CHF is important.
Identification of significant CpG markers may potentially have practical implications for disease prevention and treatment.
Identification of strategies contributing to healthy ageing is thus one of the major challenges of the coming years.
Identification of strategies mimicking key CR mechanisms - increased mitochondrial respiration and reduced production of oxygen radicals - is a hot topic in gerontology.
Identification of such patients offers the possibility of commencing or escalating treatment at an earlier stage.
Identification of the REGγ-PKA-FoxO1 pathway in endothelial cells ( ECs ) provides another potential target for therapeutic intervention in vascular diseases.
Identification of these genes has led to a number of animal models that have been useful to study the pathogenesis underlying AD.
Identification of the shock state related to cardiac dysfunction and targeted assessment of perfusion and resuscitation are important when managing elderly patients.
Identification of this critical neuronal cell type within iPSC-derived SFEBs is an important and novel step in describing cortical development in this iPSC preparation.
Identification of this mechanism may help in the diagnosis or treatment of disorders associated with oxidative stress , innate immune activation , and endothelial dysfunction.
Identification of this relationship may be useful to elucidate the origin and the pathogenesis of CSDH.
Identification of variables associated with menopausal cardiovascular consequences may be used to improve women's health after menopause.
Identification of very old persons at high risk of recurrent CVD is difficult , since traditional risk markers loose predictive value with age.
identified addressed discontinuation.
Identified brain regions and SNPs may help provide an in vivo screen for underlying pathology in FTLD and contribute to our understanding of sporadic FTLD.
Identified GABRG2 variants were functionally assessed for protein stability , trafficking , postsynaptic clustering , and receptor function.
Identified proteins are involved in processes including tissue and organ development , cell proliferation regulation and angiogenesis.
Identified the distinctive features of the metabolic reactions in children at different ages.
Identified themes , stages of acceptance , and design and development considerations are discussed.
Identifiers and triage , clinical and social data were collected.
Identify and treat complications after face-lift surgery.
Identifying and intervening with older drivers at increased crash risk is an important aspect of preventive medicine.
Identifying and managing sleep problems in childhood may improve health , including emotional well-being , in adolescence and adulthood.
Identifying and treating underlying sleep disorders along with therapeutic approach to circadian mechanism is effective.
Identifying appropriate candidates for menopausal hormone therapy ( HT ) is challenging given the complex profile of risks and benefits associated with treatment.
Identifying biomarkers predictive of clinical benefits of treatment is one of the primary goals of precision medicine.
Identifying changes in brains of aged individuals undergoing cardiac surgery may improve strategies for preventing cerebral dysfunction.
Identifying conserved and divergent response patterns in gene networks is becoming increasingly important.
Identifying factors associated with being physically active will allow for targeted interventions to improve the health of young adults.
Identifying factors associated with FrPC could inform interventions to reduce these concerns.
Identifying factors related to LTL among African Americans may yield insights into mechanisms underlying racial disparities in health.
Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation.
Identifying groups at risk for aging sexual stigma will help to focus interventions to reduce it.
Identifying how senescent cells avoid apoptosis allows for the prospective design of anti-senescence compounds to address whether homeostasis can also be restored.
Identifying intermittent and constant pain in early symptomatic OA may allow patients to adopt strategies to prevent worsening pain and future declines in physical function.
Identifying mechanisms that underlie hematopoietic aging is vital for understanding hematopoietic-related diseases.
Identifying mechanisms which influence the processes regulating skeletal muscle function is a key priority.
Identifying modifiable determinants of heart failure may help in prevention.
Identifying modifiable factors that confer susceptibility is essential for intervention.
Identifying muscle endurance capabilities in the older adult may provide an avenue to improve functional capabilities , despite a clearly established decrement in peak torque.
Identifying older adults with a mismatch between actual and perceived function has utility in clinical settings and in the design of interventions.
Identifying patients likely to experience recurrence after radical prostatectomy would lead to improved clinical outcomes , as these patients could receive adjuvant radiotherapy.
Identifying people with a poor prognosis admitted from NHs is essential to inform appropriate clinical decision making.
Identifying perceptions associated with end-of-life treatment preferences may improve interventions that facilitate quality care through patient autonomy.
Identifying processes that critically constrain executive function can advance investigation of their biological basis and treatment planning.
Identifying risk factors may help to improve patient outcomes.
Identifying sensitive diagnostic biomarkers of responsiveness to RT may inform the design of a more efficient exercise regimen to improve muscle strength in older adults.
Identifying sex-specific risk factors will inform more targeted intervention / prevention efforts.
Identifying the brain sources of neural activation during processing of emotional information remains a very challenging task.
Identifying the downstream effects of disease-associated SNPs is challenging.
Identifying the genes will help in understanding the biological basis of memory performance and allow interventions for enhancement of cognitive function.
Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders.
Identifying the key reasoning skills to develop in Algo users has led to three recommendations to enhance standardization with seniors.
Identifying these differences is essential in addressing them and preventing future traffic injuries.
Identifying these imbalances might help harness novel immune-based treatment of MM in selected elderly patients.
Identifying the significance of the changes in gene expression may help advance our understanding of the senescence biology.
Identifying those at risk of FOF can help target interventions to both prevent falls and reduce FOF.
Identify key aspects of facial aging.
Identify strategies and barriers for the recruitment and retention of older adults of racial and ethnic minorities in cognitive aging research.
Identify the essential anatomy of the face as it relates to facelift surgery.
I describe these changes on a structural and clinical basis and summarise possible solutions for a rejuvenation surgeon.
IDHAS was predominant in sexual transmit.
Idiopathic CD4 lymphopenia ( ICL ) is a rare heterogeneous immunological syndrome of unclear etiology.
Idiopathic ERM was significantly associated with age , but not with gender , best-corrected visual acuity after cataract surgery or diabetes.
Idiopathic immune myopathies ( IIM ) are an heterogeneous group of autoimmune muscle disorders characterized by progressive muscle involvement.
Idiopathic normal pressure hydrocephalus ( iNPH ) is an elderly dementia caused by abnormal metabolism in the cerebrospinal fluid ( CSF ) .
Idiopathic Parkinson disease patients with younger age at diagnosis have slower disease progression.
Idiopathic pulmonary fibrosis ( IPF ) , a heterogeneous disease with respect to clinical presentation and rates of progression , disproportionately affects older adults.
Idiopathic pulmonary fibrosis ( IPF ) is a chronic age-related lung disease with high mortality that is characterized by abnormal scarring of the lung parenchyma.
Idiopathic pulmonary fibrosis ( IPF ) is a disease of unknown origin and progression that primarily affects older adults.
Idiopathic pulmonary fibrosis ( IPF ) is an age-related multifactorial disease featuring non-uniform lung fibrosis.
Idiopathic pulmonary fibrosis ( IPF ) is a progressive fibrotic lung disease with high mortality.
Idiopathic pulmonary fibrosis is a well-known age-related disease.
Idiopathic restrictive cardiomyopathy ( RCMP ) has not been fully understood because this disease is difficult to diagnose.
I discuss the possibility that IVF for older women could raise increase the problems associated with egg procurement.
I discuss under what circumstances data from different countries can be used for inference about policy effects.
IDplex Plus gave higher peak heights in sensitivity test and tolerated inhibitors better , but had slightly worse inter-locus balances and stutter ratios.
IDS scores indicate an earlier step for conversion of SMC to MCI.
IDTS staff members add newly licensed dentists to the system as practice locations become available.
IELT and MELT were compared between men self-reporting DE and men without DE.
I employ this theoretical approach to argue that the loose criteria by which we authorize surrogates ' generally unchallenged power should be reconsidered.
I examine a number of possible explanations for differential activation in terms of task performance , neuronal computation , neuronal energetics , and network organization.
I expect that a better understanding of these ' structure-function ' relationships would lead to future diagnostic and / or therapeutic potential.
If action of a stimulating factor is quite strong , proliferation of malignant cells begins at a stage of melanocyte , and a melanoma occurs.
If action of factors is long and not strong , more remote descendants of daughter cells proliferate , and a cancer appears.
If adequate clinical response is not achieved , only then they should be supplemented with a further antidepressant.
If aging results from oxidative stress , it may be corrected by environmental , nutritional and pharmacological strategies.
If an aging male is diagnosed as late-start hypogonadism , the urologist should discuss with the patient potential benefits and risks of testosterone therapy.
If an artifact , an association would likely also have been observed in women with surgical menopause.
If and how HIV impacts the ageing process is an important and related question.
If any error was made on this test , the Farnsworth D-15 was administered under identical conditions.
If anything , there was a trend for the CR to decrease melatonin levels in the young adult females.
If a target moves slowly in the fronto-parallel plane , tracking eye movements occur that consist primarily of smooth-pursuit interspersed with corrective saccades.
If at least two participants gave answers not matching concept map definitions , items were revised and re-tested with new target group participants.
If cataract surgery was included in the model , no significant change in IOP over time was found.
If causal , the pathophysiologic mechanisms underlying this putative association remain unknown.
If causal , these associations could indicate that chronic air pollution exposure is an important risk factor for anemia in older adults.
If children lifted up the cup , the contents would be spilled and evidence of their transgression would be left behind.
If confirmed in a longitudinal study this frontal grey matter change could represent an important biomarker for trials in HIV disease.
If confirmed in a pharmacogenetic trial , ACE-Is may be found to have additional cognitive protection in a select group of elderly individuals.
If confirmed in broader populations , this finding might have both clinical and epidemiological implications.
If confirmed , this would suggest a novel mechanism leading to heightened financial exploitation risk in older adults.
If confirmed , this would suggest opportunities for quality improvement in the ED to prevent overutilization of urinary catheters.
If correct , decreasing the formation or removing amyloid should be therapeutic.
If correct , early-life risk factors likely play a key role in the development of IBS.
If culture results are positive , it is considered as evidence of the presence of bacteria in pocket in operation of PPM implantation.
If current trends continue , cancer will become the leading cause of death by @number@
If deemed appropriate , a full paper was then obtained and read.
If despite suggestive infiltrates BAL does not yield the diagnosis , CT-guided biopsy follows as soon as platelet counts allow.
If detected at an early stage , prognosis is good.
If early-life factors are important , IBS might be expected to demonstrate a birth cohort phenomenon.
If efficacy is confirmed , we will still need more information regarding the risks of TRT in older men.
If endoleak was found , CTA was performed again at @number@ months.
If energy becomes deficient , adaptive behaviors develop to conserve energy.
If EPT testing is to be applied to detect subclinical changes within a dermatome , establishment of age- and gender-specific somatotopic normograms is a prerequisite.
If erythrocyte creatine levels are high ( ≥1.8μmol / g hemoglobin ) , subclinical hemolysis is considered to be present.
If even one company succeeds , however , the impact will be huge.
If feasible , the effectiveness data will be synthesised using appropriate statistical techniques.
If further research shows EGGL does accumulate with age , removing it could be of therapeutic benefit.
If Hcrt mediates the disease process , narcoleptics should be protected against AD.
IFIH1 has been linked to a number of autoimmune disorders , including Aicardi-Goutières syndrome.
IFi has been expressed as a ratio of deficits present / deficits considered after a comprehensive geriatric assessment.
I find that models corresponding to delayed cellular senescence have younger populations that live longer.
I find that wives tend to delay retirement only until they become eligible for social security.
I first met Rosario as a research fellow in Harry Quigley's laboratory between @number@ and @number@
I fit the model to the United Kingdom's death distribution , which the original Penna model cannot do.
IFi was stratified in light , moderate and severe frailty.
If juveniles are the first to disappear when predation pressure is high , this amplifies the population's risk of extinction.
If L is a negative number the individual does not have CRI ; if L is a positive number , CRI is present.
If malnutrition could be prevented health care costs should be reduced.
If muscle mass loss has positive effects in the short term , a sustained / uncontrolled muscle mass loss is deleterious for health.
If necessary , a trial of oral or inhaled corticosteroid might be necessary.
If necessary , study teams were contacted for information.
If necessary , we contacted trial authors to ask for additional data , including relevant subscales , or for other missing information.
IFNG-inducible KYN / pteridines inflammation cascade is impacted by IFNG ( @number@ ) T / A genotypes , encoding cytokine production.
If nonoperative treatment is chosen , follow-up colonoscopy is mandatory to exclude malignancy.
If no posaconazole prophylaxis was given , voriconazole is the treatment of choice for IPA.
If no preventive / corrective measures are taken , the socio-economnic situation will get worse with economic and social damages.
If not detoxified by the endogenous glyoxalase system , it exerts its detrimental effects primarily by reacting with biopolymers such as DNA and proteins.
If not previously performed , ERCP should be offered as an alternative when surgery is contraindicated or refused.
If not properly repaired , rDNA damage may contribute to premature disease onset and aging.
If not repaired , DPCs cause stalling of DNA replication forks that consequently leads to DNA double-strand breaks , the most cytotoxic DNA lesion.
IFN-stimulated genes ( ISGs ) increased in the spinal cord of SOD1 ( G93A ) mice at a presymptomatic age.
IFN-α also inhibits AKT kinase activation but increases p38 MAPK activity , and both of these events have been shown previously to inhibit telomerase activity.
IFNβ therapy has demonstrated greater benefits in RRMS than in secondary progressive multiple sclerosis ( SPMS ) .
IFN-γ may slow proliferation of some gastric cancer cells by affecting the cell cycle to play a negative role in the development of gastric cancer.
IFN-γ plays an indirect anti-cancer role through the immune system but may have direct negative effects on cancer cells.
If obtaining a specific diagnosis is deemed crucial , then routine CT is more cost-effective in patients over @number@ years compared to younger patients.
If older people are to be more pro-active in the management of their bone health , that needs to change.
If one of the assessments presented provides abnormal results , patients should be referred to a gait specialist for an in-depth quantitative gait analysis.
If only a single anti-oxidant is used to treat a disease , it may disturb subsequent steps the oxidative / anti-oxidative chain reaction.
If oxidative processes are prevalent , it will result in oxidative stress.
If oxidative stress persists , cellular senescence is a likely outcome and an important hallmark of aging.
If pain relief was not adequate , @number@ mg kg ( @number@ ) bolus doses were allowed in @number@ min.
If participant characteristics are related to missing data , analyses should control for these factors , or they should be targeted in EMA training sessions.
If possible , these are best implemented in the form of multifactorial intervention.
If potential treatments are to be developed to treat insulin resistance , then it is important to fully understand insulin signaling and glucose metabolism.
If properly recognized and treated , lives can be saved , as well as long-term disabilities prevented.
If reflexes are incorrectly thought to be absent , important diagnostic errors may be made.
If repair is faulty or the cell is overwhelmed by damage , chances are that the cell will despair and be removed by apoptosis.
If replicated further , they suggest a multifactorial nature for WMH and argue for more consideration of vascular contributions to dementia.
If replicated in future studies , findings indicate that policies that ameliorate the impact of recessions on labour market outcomes may promote later-life cognitive function.
If replicated in other datasets , these findings may have important implications regarding the role of PGC-1α in PD and longevity.
If replicated , this observation is highly relevant in terms of public health.
If self-evaluation is lost , time sense fades , future goals based on the present time cannot exist , and behavior loses directivity.
If senescence traits can be detected with ageing in the skin , the senescent phenotype varies among the various skin cell types.
If so , how does age of first bilingual exposure impact neural activation for language ?
If so , oxidative stress-related genotypes may modify the oxidative response defenses to pollution exposure.
If so , these RBCs are quickly removed from circulation , but if the RBC levels reduce extremely fast , this results in hemolytic anemia.
If so , the underlying reasons may be more readily disclosed during private discussions with patients.
If so , what are the critical factors at play in this attention-perception-WM interaction.
If so , what does it look like , under what circumstances does it blossom , and how does it improve the aging experience ?
If so , what do they believe they are transmitting or have transmitted to their children and grandchildren ?
If so , what might prevent or mitigate it ?
If statins had no effect on functional limitation or cognitive impairment , all primary prevention strategies would prevent MIs and CHD deaths and be cost-effective.
If such misfolded proteins are allowed to linger , they may form insoluble aggregates and pose a serious threat to the cell.
If surgery was associated with physical disability , @percent@ of the people wished no surgery.
If telomeres are an aging clock , then telomerase makes an attractive target for medical technologies that seek to expand the human life- and health-spans.
If the associated dementia challenge is not adequately tackled , longevity may no longer remain desirable for aged societies.
If the AWGS ( Aisa Working Group on Sarcopenia ) standard was applied , the prevalence was @percent@ in men and @percent@ in women.
If the copper in water is too high , a simple device can be put on the tap to remove copper.
If the current trend of increasing human life expectancy persists , women will soon spend half their life postmenopause.
If the deletion occurs in a coding region , translation will result in production of misframed proteins.
If the diagnosis of IPA is not established , mucormycosis is a valid concern.
If the disease is left untreated , survival in symptomatic patients averages only @number@ to @number@ years.
If the effect is significant , we aim to clarify the age at which prognosis worsens.
If the elderly patients show these symptoms with psychosis , mania and depression , the organic or drug induced mental disorder should be excluded.
If the healthcare sky is falling , it is because we have not yet grasped the opportunity to do better.
If the infertility is only due to age the question is raised.
If the model can also identify individuals with prodromal or preclinical Parkinson's disease in prospective cohorts , it could facilitate identification of biomarkers and interventions.
If the neurotoxicity of anaesthetics in human remains debatable , perioperative period is certainly a high-risk factor for cognitive impairment , especially in elderly population.
If the operation is tolerable for the elderly patient , curative resection should be performed.
If theory of mind is lost , awareness of one's desire and intention becomes vague , and toilet activities begin to collapse.
If the pathophysiology is not clearly defined , they are also called idiopathic.
If the patient continued to have diarrhea on follow-up , @percent@ contacted the patient's physician.
If the QT interval is more than half the RR interval , QTc interval prolongation is likely to be present.
If there is an association between SUA and hypertrophy in these patients , it is unknown whether the association is different between men and women.
If there is an explanation to infertility ( male or tubal infertility ) ART is better than abstention.
If the results from mice were confirmed in human studies , an irisin-based therapy could be developed for physically disabled or bedridden patients.
If there was no medication review at baseline , the impact of polypharmacy on depression was subsided.
If these are ruled out , pharmacological agents in combination with psychosocial interventions are important treatments for older patients with schizophrenia and depressive symptoms.
If these changes are so severe that their compensation is no longer possible , presbydysphagia occurs.
If these oscillations persist , then someone we know well may suggest consulting a physician because our bad days are interfering with our daily activities.
If these repair processes fail , oxidized proteins may become cytotoxic.
If these results are replicated , leukocyte telomere length may prove to be a useful predictor of age at menopause.
If these trends continue , we predict this rising to @number@ in @number@ @number@ in @number@
If the TM is damaged , aqueous outflow is impaired , IOP increases and glaucoma can manifest.
If they answered ' yes' , further questions were asked regarding clinical characteristics.
If this balance becomes destroyed the free zinc level might increase and cause toxic effects.
If this is correct , detection of this process has substantial implications for physiological organization more generally.
If this is not possible , then the chest wall closure should be reinforced with either mesh , soft tissue , or both.
If this is so , we would expect to see a similar prevalence of SVH in younger women.
If this is the case , a mitochondria-targeted antioxidant might be an inhibitor of the aging program.
If those assessments provide pathological results , then consider patient referral for an in-depth gait analysis.
If treatments are tailored to the skin of the chest , the incidence of adverse events is lower , and patients can be safely treated.
If true , this suggests that a life course approach to preventing cognitive impairment is desirable.
If trust fund assets are exhausted without reform , benefits will necessarily be lowered with no effect on budget deficits.
If unaccounted for , this high degree of homology can cause serious genotyping or sequencing errors.
If unchecked , ROS production and oxidative stress mediate tissue and cell damage that can spiral in a cycle of inflammation and more oxidative stress.
If untreated , ischaemic complications can be catastrophic for the patient , including blindness.
If validated , this mechanism would present a challenging but not impossible target for medical intervention.
If validated , this mechanism would present a challenging target for medical intervention.
If validated through clinical trial the treatment protocol for wet AMD can be more precise and tailored to individual patients.
If we aim for healthy ageing across the life course , we need to clarify the meaning of health at different ages.
If we find a new treatment for microcirculatory disorders , maybe we can treat both sensory impairments in earlier stage.
If we refer to the Western Europe countries and North America , we notice an increase of esophageal adenocarcinoma rate versus squamous cancer.
If you have incorrect answers , return to the article for further study.
IgA nephritis remains the most common GN.
IgA nephropathy ( IgAN ) represents the most common primary glomerulonephritis worldwide with a prevalence of 25-50% among patients with primary glomerulopathies.
IgAN was proven by biopsy.
IgA PRIG activity varies significantly more than IgG PRIG activity and , besides , IgA PRIG significantly less depends on age than IgG PRIG.
IgA was lower in patients than in controls , but other parameters did not differ.
IGF-1 accounted for about @percent@ of the inter-individual variation in LTL over and above the effect of age.
IGF-1 , a mediator of growth hormone ( GH ) , was subsequently shown to induce interleukin-7 secretion in cultured primary human thymic epithelial cells.
IGF1Ea and IGF1Ec mRNA expression in muscle was higher in ACRO patients versus GHD patients ( P < 0.01 ) .
IGF1 / IGFBP3 molar ratio is an indicator of IGF1 bioavailability.
IGF1-induced osteoblast differentiation was also impaired in Terc ( - / - ) MSC.
IGF1 is an important mediator of muscle growth and regeneration affecting muscle function.
IGF1 is a sensitive tool for the diagnosis of acromegaly and efficacy of therapies.
IGF1 is involved in growth and development and is successfully used in tissue-engineering for cartilage repair.
IGF-1 is predominantly associated with perceived age by skin wrinkling , whereas cortisol and glucose also by other skin aging features.
IGF1 level was < -2 SDS in @percent@ of treated patients at transfer and in @percent@ of them after @number@ years of treatment.
IGF-1 mediates effects of physical exercise on the brain , and cognition has a common pathophysiology with physical function , particularly with gait.
IGF-1R and FOXO3A mRNA and protein were more abundantly expressed in muscle samples of HRT users than nonusers.
IGF-1R ( + ) hCSCs improved cardiomyogenesis and vasculogenesis.
IGF1 was associated with two , IGFBP1 with four and IGFBP3 with all five components of the metabolic syndrome.
IGF1 was statistically significantly higher in males with p < 0.0001 ( Wilcoxon test ) but decreased faster ( p = 0.0121 ) .
IGF2R gene expression was in positive correlation with PDL.
IGF-binding protein @number@ ( IGFBP2 ) is secreted by white adipocytes and contributes to the prevention of diet-induced obesity and age-related insulin resistance in mice.
IGFBP-1 in second-third quartiles was negatively associated and that in the fourth quartiles was positively associated with risk of death.
IGFBP-1 was associated with bone health , though the effect could be explained by other factors.
IGFBP2 mRNA levels were also decreased in visceral WAT of @number@ and @number@ months old mice compared with those of their @number@ months old counterparts.
IGFBP-3 and IGF-I were independent determinants of bone health in middle-aged and elderly European men.
IGFBP-3 concentrations increase until the age of @number@ years , with a plateau being visible between @number@ and @number@ years.
IGFBP-3 is internalized through a dynamin-dependent pathway , traffics through endocytic compartments and is finally delivered into the nucleus.
IGFBP3 is the most abundant of the carrier proteins for IGF1 in the blood.
IGFBP3 was statistically significantly higher in females with p = 0.0004 ( Wilcoxon test ) but decreased faster ( p < 0.0001 ) .
IGFBP complexes did not bind Human telomeres and promoter regions of genes fulfill a significant role in cellular aging and cancer.
IgG4 / MFS-related HP cases showed a marked male predominance ; all had cranial HP while none had isolated spinal HP or decreased sensation.
IgG in none of the @number@ CSF samples from patients with multiple sclerosis bound to KIR4.1-transfected cells.
IgG in none of the @number@ serum samples from clinic-based patients immunoprecipitated KIR4.1 , but a commercial KIR4.1-specific control IgG did.
IgG subclass specific glycosylation patterns were obtained from @number@ participants in the LLS by MALDI-TOF-MS analysis of tryptic IgG Fc glycopeptides.
IGH monoclonality could be demonstrated in @number@ of @number@ investigated cases.
Ignatz Nascher's Geriatrics the first American medical textbook on aging turns @number@ this year.
Ignoring the competing mortality risk may overestimate long-term care needs and costs.
Ignoring the impact of death yielded a @percent@ smaller estimate of the effect of baseline diabetes on cognitive decline.
IG volume was defined as the difference between final infarct volume and baseline diffusion-weighted imaging volume.
IHC may be an alternative to molecular biology approaches for the routine detection of this mutation in PTC patients.
IHD , Af and vasospastic angina ( VSA ) were complicated in @number@ @number@ and @number@ patients , respectively.
I identify the motivations driving cognitive support work and discuss the role of lay health knowledge in dementia caregiving.
I identify three stages through which such support takes shape and then gradually declines in usage.
IIEF5 scores of depression patients were significantly lower than those of non-depression patients.
IIEF scores , however , did not differ significantly by age category.
IIEF scores of ED groups were between @number@ and @number@ and 6-16 in turn.
I.I. Mechnikov's hypothesis that the key to prolongation of life lies in the introduction of useful microflora to the gut was not proved.
I investigated the association between depression and percent body fat , two major global problems.
IIV shares significant genetic variance with fluid ability in late adulthood , over and above and genetic variance shared with mean reaction time.
IKDC subjective score improved from @number@ ± @number@ to @number@ ± @number@ at @number@ years.
IL-15 could play a role enhancing the effector response of CD4 + CD28 ( null ) T cells against their specific chronic antigens.
IL-15 induced an activated phenotype in CD4 + CD28 ( null ) T cells.
IL-17 and ANGPT2 were estimated in both the groups.
IL-17 is known to be involved in a number of chronic disorders although the mechanisms regulating its production in inflammatory disease are still unclear.
IL-18 and IL- @date@ play important roles in the pathogenesis of comorbidity in COPD patients.
IL-1β treatment resulted in increased accumulation of NO , increased expression of ADAMTS-5 and iNOS , whereas the accumulation of proteoglycan in alginate beads decreased.
IL-21 is secreted by activated CD4 T cells and natural killer T cells.
IL-21R-Fc treated mice also decreased the production of IgG , STAT3 phosphorylation , and plasma cell transcription factor ( Blimp1 ) .
IL-22 stimulates the production of acute phase reactants and promotes the antimicrobial defense.
IL-27Receptor ( R ) expression was assessed in lung tissues from @number@ NSCLC patients.
IL-27's effects were tested on Adenocarcinoma ( AC ) and Squamous Cell Carcinoma ( SCC ) cell lines and xenograft models.
IL-2-activated NK cells of the oldest seniors showed the highest increase of telomerase activity as compared to the other age groups.
IL-30 regulation of hPCa cell viability and expression of selected gene clusters was tested by flow cytometry and PCR array.
IL30 was absent in normal mammary ducts , ductules , and acini of histologically normal breast and scanty in the few stromal infiltrating leukocytes.
IL-6 and MT2A polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) method.
IL-6 genotypes displayed no difference at baseline.
IL-6 , hepcidin , GDF15 , EPO and testosterone levels were compared.
IL6 level at the highest quartile showed an independent association with ADL disability ( SRH = 1.32 ; @percent@ CI : @number@ @number@ ) .
IL-6 levels in the Enhanced group returned to pre operative level @number@ days after surgery.
IL-6 levels were lower in the EG on @number@ @number@ and @number@ days post-operatively ( p @number@ ) .
IL-6 levels were measured using ELISA.
IL-6 levels were significantly correlated with body mass index and within schizophrenia patients , with worse mental and physical well-being.
IL-6 suppresses feeding in the absence of neuronal IL-6-receptor ( IL-6R ) expression in hypothalamic or all forebrain neurons of mice.
IL arteriolae showed focal areas of degeneration with a wide individual and inter-individual range of intensity and extension , but not related with age.
Ileocolonoscopic examinations were done at baseline and week @number@
Illness attributes may influence depression under-treatment by shaping help-seeking and physician recognition in older and minority men.
Illnesses were ascertained from medical records.
Illness perception was generally correct.
Illumina HumanMethylation450 BeadChip was used to measure methylation.
IlluminOss™ is an innovative technology featuring cement with similar biochemical characteristics to aluminum-free glass-polyalkenoate cement ( GPC ) .
Illusory correlations were implicitly measured via a multinomial model.
Illustrative in this respect is the insulin / IGF-1 signaling pathway acting through PI3K / PKB and FOXO.
ILM was associated with lower percept scores and higher activations in ACC relative to real motion , but no differences in shape-selective areas emerged.
I look at risks to women and offspring , and also consider questions of efficacy and cost-effectiveness.
IL septae had changes with extremely variable intensity , dispersed mainly in L periphery , without significant spread and without extensive trend with ageing.
Image-analysis algorithms have been effective at characterizing fibrous constructs using various microscopy modalities.
Image analyzing software was used to measure distances and areas of interest of midsagittal and midaxial spine images.
Image colors were then rendered from the adapted channels ' outputs.
Image-guided radiofrequency ablation is a new emerging modality of treatment which may be applicable in this high-risk group of patients.
Imagery cognitive bias modification significantly increased the vividness of positive prospective imagery post-training , compared with the control training.
Images from volunteers were compared to those obtained in the post-mortem study.
Images of CMs mitoses were seen in the 17-day newborns.
Images of five males and five females at young and middle ages were morphed in @percent@ increments to create aged face images across the lifespan.
Images of the central endothelium were obtained preoperatively and at intervals for @number@ years postoperatively.
Images of the histological slices were analyzed and captured under 400x magnification with digital camera.
Images of women's sexuality beyond the age of forty are lacking in popular culture.
Images were acquired and measured with a specialized software.
Images were analyzed and LT measured assuming a refractive index of @number@
Images were analyzed by a central image analysis reading center to determine endothelial cell density ( ECD ) .
Images were re-evaluated with HRT III and ONHs graded as normal , borderline or glaucomatous with the Moorfield Regression Analysis ( MRA ) .
Imagination at home.
Imagined gait protocols overcome this limitation.
Imagined walking time ( IWT ) was measured as a control of behavioral performance during fMRI.
Imaging analyses with magnetic resonance scan showed diffuse atrophy in the frontoparietal regions.
Imaging analysis revealed that patients who exhibited disgusting behaviors had significantly less gray matter volume bilaterally in the ventral anterior insula.
Imaging and limited neuropathological data suggest possible abnormalities in myelination and / or glial function.
Imaging and proteomics approaches were used to identify and quantify Aβ deposits in AD heart and brain specimens compared with controls.
Imaging and quantification of collagen density were carried out using multiphoton laser scanning microscopy ( MPLSM ) .
Imaging biomarkers related to memory performance included the orbito-frontal and medial temporal cortical regions with LTM showing stronger correlation with the temporal lobe than STM.
Imaging detection of fascicular lesions allows for more accurate localization , because fascicular lesion types represent a specific pitfall for examinations.
Imaging diagnostics ( ultrasound or CT ) , when considered alone , are also of little use for the purpose of clarifying thyroid gland function.
Imaging is strongly recommended to determine the extent of disease.
Imaging is the optimal method to follow the effect of treatments since changes in MRI scans are seen prior to those in cognition.
Imaging metabolic characteristics of tumors by MRI and ( @number@ ) C-nuclear magnetic resonance was described.
IMAGING @number@ ; 45 : 1684-1692.
IMAGING @number@ ; 46 : 61-70.
Imaging remains the preferred method for evaluating patients with dysphagia , and dysphagia is an increasingly encountered indication for radiologic evaluation.
Imaging studies in healthy individuals show that dynamic brain activation changes with practice.
Imaging studies of ancient human mummies have demonstrated the presence of vascular calcification that is consistent with the presence of atherosclerosis.
Imaging was performed a mean of @number@ months ( range , @number@ to @number@ months ) before death.
IMA might be a new useful biomarker correlated with mild cognitive impairment of the patients.
Imbalance in the 3R-tau / 4R-tau ratio causes neurofibrillary degeneration and dementia.
Imbalance of oxidative stress biomarkers together with abnormalities in the mitochondrial network and function are consistent with a pro-oxidant state.
IM characterizes masking effects caused by irrelevant information from competing speakers.
IMF-EMG was overall higher in elders , with significant differences at the L5 recordings sites.
Imitation style varied depending on the prompt given , with certain actions showing a side bias regardless of prompt viewed.
Immediate adjuvant treatment was carried out in @number@ patients.
Immediately after brain activation , the rate of glycolysis exceeds oxidation , leading to net production of lactate.
Immediately after treatment , vaporization was produced by stacked pulses , with clear ablation and collateral heat coagulation.
Immediate postoperative adjuvant treatment was carried out in @number@ patients.
Immediate referral to specialists was more common in the recent study.
Immense research is being carried out to identify potential plants with potent anti-oxidant activity against skin ageing.
Immersion for @number@ week in hot @number@ vol% acetic acid weakened all @number@ zirconia materials by @number@ to @number@ MPa.
Immersive tendencies and absorption scales were administered before the session.
Immigrants ' cumulated length of hospital stay tended to be shorter than or similar to that of Canadian-born seniors.
Immigrants make up over @percent@ of the population in Germany , yet the majority receive inadequate medical care.
Immigrants performed more poorly than nonimmigrants , but an identical correlation between participant age and naming scores was found in both groups.
Immigrants were categorised according to country of origin , reason for migration and length of stay in Norway.
Immmunostaining for CD66b was performed in @number@ sections as described.
Immobilized metal affinity chromatography and titanium dioxide chromatography can greatly assist selective phosphopeptide enrichment.
Immonohistochemical identification of a fibromyxosarcoma in rats.
Immune activation and persistent inflammation characterizes both HIV infection and physiological aging , and both conditions share common detrimental pathways that lead to early immunosenescence.
Immune activation was measured via cytokines in cerebrospinal fluid ( CSF ) .
Immune aging in RA T cells is also associated with metabolic reprogramming ; specifically , with reduced glycolytic flux and diminished ATP production.
Immune aging occurs in the elderly and in autoimmune diseases.
Immune challenge in mice lacking Mef2C in microglia results in an exaggerated microglial response and has an adverse effect on mice behaviour.
Immune checkpoint inhibition is a novel treatment modality that has brought a new hope to patients with advanced NSCLC.
Immune-competent adults submitted to complete thymectomy early in life provide a unique model to address this question.
Immune decline with ageing accounts for the increased risk of infections , inflammatory chronic disease , autoimmunity and cancer in humans.
Immune dysfunctions in the elderly result in increased susceptibility to infectious diseases , cancer , and autoimmune diseases.
Immune enhancement is desirable in situations where decreased immunity results in increased morbidity.
Immune impairment and high circulating level of pro-inflammatory cytokines are landmarks of human aging.
Immune-mediated inflammatory processes are regulated by neuroendocrine hormones , including glucocorticoids , dehydroepiandrosterone , and the catecholamines , epinephrine , and norepinephrine.
Immune parameters , including neutralizing and binding antibodies and RhCMV-specific T cell responses , were assessed in longitudinally collected blood samples.
Immune profiles are modulated by thymic output , cell migration , shedding of markers , proliferation , survival and in-situ evolution of regulatory cells.
Immune profiling of non-obese diabetic ( NOD ) is a widely employed tool to assess the mechanisms of inflammatory insulitis.
Immune reconstitution inflammatory response syndrome and toxicities related to HAART may also result in ICU admission.
Immune reconstitution inflammatory syndrome is a direct complication of ART whose manifestations vary with the underlying disease.
Immune response is a critical factor in determining the progress of neurodegeneration after stroke and is fundamentally different for males and females.
Immune risk phenotypes were distinctly demonstrated between survivors and non-survivors.
\ "Immune senescence \ " is a descriptive term for the deleterious age-associated changes to immunity observed in all mammals studied so far.
Immune system aging functions as an accelerator for other age-related pathologies.
Immune system function declines with age.
Immune system function is altered by many conditions , such as aging , malnutrition and mycobacterial infections.
Immune tolerant cancer cells gains more nutrients during the inflammation.
Immunity to pneumococcal infections is impaired in older people , and current vaccines are poorly protective against pneumococcal disease in this population.
Immunoblot analysis with a panel of amyloid-β antibodies confirmed accumulation of high concentration of amyloid-β in basal forebrain early in adult life.
Immunoblots of affinity-purified DAF from erythrocytes of patients with diabetes showed pentosidine , glyoxal-AGEs , carboxymethyllysine , and argpyrimidine.
Immunoblotting and immunofluorescence cytochemical studies further suggest that CST1 accumulates intracellularly , within vesicular structures.
Immunoblotting was used to determine phosphorylation of cyclin-dependent kinase-2 and protein expression of p27 ( Kip1 ) and cyclin D1.
Immunoblotting with affinity-purified rabbit polyclonal anti-HPV @number@ E7 antisera and q-RT-PCR analysis suggest that these cells do probably not express HPV-16 E7.
Immunochromatography ( IC ) and restriction fragment length polymorphism polymerase chain reaction ( PCR-RFLP ) were performed on the conjunctival swabs obtained from each eye.
Immunochromatography tests were positive for adenovirus in @number@ ( @percent@ ) out of @number@ eyes.
Immunocytochemical analyses revealed that Aβ-O induced aberrant phosphorylation and caspase-mediated cleavage of tau , both of which were mostly reversed by Aβ-O removal.
Immunocytochemical analysis revealed that SVBP colocalized with VASH1 in ECs.
Immunocytochemistry analysis showed that @date@ is expressed in the nuclei of LNCaP cells. siRNA-mediated silencing of @date@ expression inhibited LNCaP cell proliferation.
Immunodeficiency has the characteristics of premature ageing across multiple cellular and molecular immune parameters.
Immuno-electron microscopy determined that both tau and 14-3-3ζ are present in these ultrastructures and that they are formed in an incubation time-dependent manner.
Immunofluorescence analysis identified a colocalization of the WT protein with the endoplasmic reticulum and a notable aggregating pattern for the truncated protein.
Immunofluorescence analysis revealed reduced full-length mutant APP and soluble / insoluble Aβ levels in the SS31-treated APP mice.
Immuno-fluorescence analysis showed that Akt phosphorylation found in the epidermal cells ( with increased levels of NF-κB activation ) were also found.
Immunofluorescence and confocal microscopy analyses revealed that SR3677 alters BACE1 endocytic distribution and promotes amyloid precursor protein ( APP ) traffic to lysosomes.
Immunofluorescence and flow cytometry revealed that EGFR was internalized in H. pylori-infected cells after EGFR phosphorylation in a p38-dependent manner.
Immunofluorescence microscopy showed that γH2AX foci and TIFs were increased by SIRT6 inhibition.
Immunofluorescence showed that the proportion of OGG1-positive cells decreased significantly in ARC cortex in comparison with the control.
Immunofluorescence staining revealed localization of ABCA1 on both sides of polarized RPE cells.
Immunofluorescence study revealed Tie1 expression in the endothelium of samples of all experimental groups.
Immunofluorescent staining showed increases in the levels of IL-8 and CXCL10 proteins in neurons and glial cells.
Immunogenic capacity was investigated by evaluating the activation of allogeneic lymphocytes and monocytes in co-cultures with ECFC.
Immunogenicity of native and MG-Lys-Cu ( 2 + ) -DNA was probed in female rabbits.
Immunohistochemical analyses of human brain sections from AD and non-AD subjects revealed that ABCA7 is expressed in neuron and microglia cells in the cerebral cortex.
Immunohistochemical analysis and polymerase chain reaction technology were utilized to measure key biomarkers.
Immunohistochemical analysis confirmed similar tissue MMP-1 expression with or without TNF-α with epidermis being the major source of MMP-1.
Immunohistochemical analysis of tissues was performed using anti-GGT1 antibody.
Immunohistochemical data correlated with improvements in skin elasticity and pliability evaluated by cutometry , and with ultrasound-assessed increases in dermal thickness.
Immunohistochemical expression of TTF-1 , p63 , chromogranin , synaptophysin , CD56 and bcl-2 was assessed.
Immunohistochemical findings revealed significant epidermal p53 reduction and dermal collagen @number@ increase.
Immunohistochemical localization of D-β-Asp-containing proteins was investigated in surgical specimens of pterygium from @number@ patients and control specimens from @number@ patients.
Immunohistochemical markers are widely used in neuropathologic diagnostic practice and help to understand the pathogenesis of diseases.
Immunohistochemical neuropathological examinations were performed following the universally accepted guidelines.
Immunohistochemical periostin expression was determined in kidney tissues from overt diabetic nephropathy.
Immunohistochemical results also demonstrated that LYC significantly restored the expression of glial cells inflammatory makers Iba-1 and GFAP.
Immunohistochemical staining for HOXA4 showed nuclear and perinuclear staining in endothelial and smooth muscle cells in aorta.
Immunohistochemical staining for SMP-30 was performed in biopsy specimen after living donor liver transplantation ( LDLT ) .
Immunohistochemical staining in human PCa tissue microarrays revealed ATM expression is highly correlated with TR4 expression.
Immunohistochemical staining of ( 8-OHdG ) and APE1 was performed.
Immunohistochemical staining of amygdalae for Aβ , Tau , α-synuclein , and TDP-43 highlight the often-coexisting pathologies.
Immunohistochemical staining was used to analyze the variation of BDNF expressions in different brain regions of the aging rats with different treatments.
Immunohistochemical studies revealed that while CD34 and UEA-I were colocalized in young eyes , there was variable loss of CD34 immunoreactivity in older donor eyes.
Immunohistochemical studies showed high expression of IL-8 , coinciding with a marked infiltration of polymorphonuclears and CD68 + cells in the synovium.
Immunohistochemistry analysis revealed hiPSC-smooth muscle tissue with robust , well-organized cells and elastic fibers and the supporting microfibril proteins necessary for elastic fiber assembly.
Immunohistochemistry and immunoblotting of the patient's brain revealed tau deposits composed mostly of 3Rtau isoforms with a predominance of the shorter 3Rtau isoforms.
Immunohistochemistry and non-isotopic in situ hybridization showed that apo D is synthesised in both neurons and glial cells.
Immunohistochemistry confirmed localization of SGCD protein to airway smooth muscle and vessels and MYH15 to airway epithelium , vascular endothelium , and inflammatory cells.
Immunohistochemistry defined the relationship between amyloid and Iba1 profiles.
Immunohistochemistry demonstrated the localization of MDA5 in all affected target tissues.
Immunohistochemistry expressed positive EBER-ISH.
Immunohistochemistry for each NRXN also revealed different expression patterns at this stage of development.
Immunohistochemistry ( IHC ) and in situ hybridization ( ISH ) were carried out to semi-quantitatively detect the expression level of CyPA and CD147.
Immunohistochemistry of macrophages has also been performed.
Immunohistochemistry revealed a prominent gender effect in young adults.
Immunohistochemistry revealed ubiquitin-positive , TAR DNA-binding @number@ kDa-positive , TFG-positive inclusions in the remaining LMNs.
Immunohistochemistry showed BRI2 deposits associated with amyloid-β plaques in early pathologic stages ( Braak-III ; Thal- @date@ ) .
Immunohistochemistry studies demonstrated that the selected proteins were found to be less abundant in aged group explants vs. young group except for decorin.
Immunohistochemistry was applied to assess skeletal muscle fiber type-specific composition , size , and satellite cell content.
Immunohistochemistry was done using antibodies against neurofilament , synaptophysin , S-100 , and collagen IV.
Immunohistochemistry was employed to identify neuronal and glial TDP-43 pathology in the central nervous system ( CNS ) in patients and COs.
Immunohistochemistry was performed for PAOs using a conformation-specific antibody , as well as for candidate proteins identified previously in isolated atrial amyloidosis.
Immunohistochemistry was performed to evaluate TF protein expression.
Immunohistochemistry , western blotting and unbiased proteome-wide meta-analysis revealed altered expression of this glioblastoma control module in human glioma samples as compared with normal controls.
Immunohistological analyses revealed that active Caspase-6 was abundant in goblet cells and epithelial cells sloughing off the intestinal lining of the adult colon.
Immunohistological evaluation revealed a significant decrease in vascular areas and endothelial surface in CC with aging , despite no differences found in vessel number.
Immunological impairment is also implicated as a part of the pathogenesis in Alzheimer's disease ( AD ) .
Immunological status is largely determined by age and comorbidities , but is also affected by other less well known factors.
Immunological variation can impact defense mechanisms , however.
Immunologic memory is a critical feature of the adaptive immune system to fight recurrent infections.
Immunophenotyping has become the most important diagnostic method after @number@
Immunophenotyping was performed in @number@ ALL patients by flow cytometry using a panel of monoclonal antibodies and CD45 / SSC gating.
Immunoprecipitation and pulldown analyses revealed that Plk3 physically interacted with HIF-1α under hypoxia.
Immunoprecipitation experiments demonstrate that FBG1 and APC2 interact directly.
Immunoprecipitation of TDP-43 showed that flies with hTDP-43 mutations had increased levels of ubiquitination and phosphorylation of the hTDP-43 protein.
Immunoprecipitation was used to detect Prom1 interacting proteins.
Immunoquantum dots have been widely employed for single molecule imaging.
Immunosenescence affects both innate and adaptive immune reactions.
Immunosenescence , concomitantly with inflamm-aging , is considered as the leading cause of age-related diseases including cardiovascular , neurodegenerative and metabolic diseases , and cancer.
Immunosenescence defines the decline in immune function that occurs with aging.
Immunosenescence enhances the susceptibility to viral infections and renders vaccination less effective.
Immunosenescence is a hallmark of the aging immune system and is considered the main cause of a reduced vaccine efficacy in the elderly.
Immunosenescence is an age-related reduction of immune system activity that can be associated with frailty.
Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions.
Immunosenescence is a series of age-related changes that affect the immune system and , with time , lead to increased vulnerability to infectious diseases.
Immunosenescence is characterized by a decreased ability of immune cells to mount a productive response upon exposure to new antigens.
Immunosenescence is characterized by a decrease in innate and adaptive cell-mediated immune function in the peripheral blood and the bone marrow.
Immunosenescence is defined as changes in the innate and adaptive immune response associated with increased age.
Immunosenescence is the functional deterioration of the immune system during natural aging.
Immunosenescence is thought to result from cellular aging and to reflect exposure to environmental stressors and antigens , including cytomegalovirus ( CMV ) .
Immunosenescence , multiple comorbid diseases , and grouped quarter living all coalesce in nursing home residents to increase the risk for infectious disease.
Immunosenescence plays a crucial role in aging and leads to the shrinkage of T cell repertoire and the propensity to apoptosis.
Immunosenescence refers to age-associated changes in the immune system , which may be associated with susceptibility to infections and their clinical complications.
Immunostaining detected intracellular PAOs in a majority of atrial samples , with a heterogeneous distribution throughout the myocardium.
Immunostaining established that CD33 is expressed in microglia in human brain.
Immunostaining for AGEs and RAGE was performed and the intensity of staining measured.
Immunostaining of clinical samples indicated that NOX5 was overexpressed in @percent@ of breast ductal carcinoma samples.
Immunostaining was performed to determine change in type I and III collagen levels and stem and other cell counts in skin layers.
Immunostaining was strongest in the neuronal perinuclear region and absent in the nucleus.
Immunosuppression resulted in lower rates of end-stage renal disease at @number@ year and lower mortality at @number@ years.
Immunotherapy has become a crucial modality for non-small-cell lung cancer treatment.
IMPACT : Dietary recommendations for cancer prevention are applicable to the elderly.
IMPACT : Further investigation of interventions that impact depression and telomere length may be warranted in patients with cancer.
IMPACT : Future epidemiologic studies should collect feces using @percent@ ethanol or FOBT if interested in studying fecal metabolomics.
IMPACT : Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.
IMPACT : Larger studies , preferably with repeated measures over time , will be required to establish associations between specific probes and exposures.
Impact of each N-of-1 trial was measured on the clinician's intention to treat and confidence.
Impact of frailty on HF risk is not known.
Impact of race / ethnicity ( Caucasian , black , Asian , Hispanic ) on severity of each feature was assessed.
IMPACT ON INDUSTRY : Future research on the ability of driving self-restrictions to reduce actual crash risk and prevent injuries is needed.
IMPACT ON INDUSTRY : None.
IMPACT : Our results suggest no interaction between NAT2 genotype and red meat intake in mediating risk of colorectal cancer.
IMPACT : Promoting Internet use among older adults from all backgrounds could contribute to improving cancer outcomes and reducing inequalities.
IMPACT : Results suggest no evidence of strong gene-environment interactions involving the recently identified @number@ susceptibility loci for colorectal cancer taken one at a time.
Impact scores for equivalent levels of symptom frequency ( mild , moderate and severe symptoms ) were compared in women of different ages.
Impacts of radio- and chemotherapy increased and impact of surgery decreased with more advanced cancer stages.
Impacts of sex and reproductive stage on performance were tested.
Impact statement Somatic mutations cause cancer , possibly other diseases and aging.
IMPACT survey participants were recruited via the Internet in equal numbers from @number@ European countries-France , Germany , Italy , Spain and the United Kingdom.
IMPACT : The causal association between BMI SNPs and endometrial cancer has possible implications for endometrial cancer risk modeling.
IMPACT : There was no association observed between genetic markers of circulating 25 ( OH ) D and colorectal cancer.
IMPACT : These methylation changes could inform the development of early detection biomarkers and potential treatments of inflammation-related carcinogenesis.
IMPACT : The strong protective effect of lower gastrointestinal endoscopy may be compromised by continued smoking.
IMPACT : This is the first epidemiologic study to implicate the receptor for AGEs in colorectal cancer development.
IMPACT : This may offer an alternative cost-efficient way to study TL in extracted DNA samples.
IMPACT : This study shows that one measurement can reliably assess methylation of differentially methylated CpG loci.
IMPACT : Tobacco and alcohol do not appear to be carcinogenic for male breast cancer.
Impaired ability to modulate activity was associated with increasing age , greater amyloid burden , and worse memory performance.
Impaired activity and reduced expression of antioxidant proteins have been reported as common events in several aging-associated disorders.
Impaired autophagy function and enhanced ARG2 ( arginase @number@ ) -MTOR ( mechanistic target of rapamycin ) crosstalk are implicated in vascular aging and atherosclerosis.
Impaired axonal transport has been linked to the pathogenic processes of Alzheimer's disease ( AD ) in which axonal swelling and degeneration are prevalent.
Impaired brain iron homeostasis has been recognized as an important mechanism underlying the pathogenesis of this disease.
Impaired CD4⁺ T-cell composition persisted in patients who initiated cART at < 350 CD4⁺ T cells per microliter.
Impaired circadian rhythmicity is related to a decrease of NO production with aging , suggesting the important role of NO for age-associated diseases.
Impaired cognition is a recognized characteristic of the frail older adult.
Impaired cognitive function is increasingly recognized in COPD.
Impaired cognitive functions as well as problems affecting hand joints make using inhaled medications less reliable which leads to further deterioration of outcome of care.
Impaired decision-makers displayed higher prediction error ( difference between their prediction and actual outcome ) .
Impaired diastolic recovery of energy stored by systolic proximal aortic stretch may contribute to increased susceptibility to diastolic dysfunction in women.
Impaired DNA damage response , even modest one , could thus lead to premature neuron aging and mortality.
Impaired emotion recognition in aMCI was independent of patient mood and cognitive deficits.
Impaired epidermal barrier function and delayed cutaneous recovery after insult enhances susceptibility to both irritants and allergens.
Impaired episodic memory in AD results from the dysfunction of an integrated network and involves both gray and white matter pathologies.
Impaired excitatory afferent feedback with ageing may , therefore , alter motor control.
Impaired growth factor function is thought to drive many of the alterations observed in Alzheimer's disease ( AD ) patients.
Impaired hippocampal Wnt signaling is implicated in several of these conditions , however , little is known about how Wnt signaling mediates hippocampal memory formation.
Impaired insight into illness is a common but poorly understood phenomenon in schizophrenia.
Impaired insulin signaling and insulin resistance in brain have been found to play an important role in the pathogenesis of AD.
Impaired learning and memory performance is often found in aging as an early sign of dementia.
Impaired liver regeneration has been reported in aged animals.
Impaired maternal folate intake and status increases the risk of neural tube defects.
Impaired microcirculation caused by age effect , when coupled with sedentary lifestyle , was found to be more likely to evoke ischemia shoulder pain.
Impaired mobility and falls associated with gait disorders significantly contribute to a reduced quality of life in the elderly.
Impaired mobility is a precursor to disability , which has notable clinical significance and importance to older adults.
Impaired motor skill acquisition is a feature of older age.
Impaired NK cell maturation in aged mice correlated with a reduced capacity to eliminate allogeneic and B16 tumor targets in vivo.
Impaired olfaction has been described as an early symptom in Alzheimer's disease ( AD ) .
Impaired olfaction is another hallmark of AD tightly related to tau pathology in the olfactory pathways.
Impaired physical function is a major indicator of frailty , and functional performance tests are useful for the identification of frailty.
Impaired physical growth and dental development seem to have common risk factors.
Impaired PMN functions prior to surgery were related to alterations in PI3K and NF-κB signaling pathways.
Impaired proliferation of either PERK or eIF2αP-deficient primary cells is caused by increased ROS and restored by anti-oxidant treatment.
Impaired proteasome activity may also enhance accumulation of other proteins associated with this variant.
Impaired response flexibility may contribute to reduced ability to modify goal-directed behavior in BD appropriately.
Impaired skeletal muscle efficiency potentially contributes to the age-related decline in exercise capacity and may explain the altered haemodynamic response to exercise in the elderly.
Impaired sleep may be a risk factor for developing disease and be a risk marker for underlying illness or sleep disorders.
Impaired stair negotiation could be an acute response to exercise.
Impaired synaptic plasticity is implicated in the functional decline of the nervous system associated with ageing.
Impaired trabecular corticalization during growth , and cortical and trabecular fragmentation during aging , may contribute to the fragility of the distal radius.
Impaired verticality perception can cause falls , or even the inability to stand , due to lateropulsion or retropulsion.
Impaired Work-Mem and structural and functional abnormalities of the ACC are reported in schizophrenia.
Impairment increases rapidly with age but differs considerably between countries.
Impairment in schizophrenia is more severe in patients with negative symptoms-especially flat affect-who also show deficits in measures of social cognition.
Impairment in verbal working memory in contrast may reflect mechanisms specific to schizophrenia.
Impairment of autophagy might disrupt the antioxidant defense system which renders melanocytes to oxidative insults.
Impairment of hippocampus-dependent cognitive processes has been proposed to underlie age-related deficits in navigation.
Impairment of mitochondrial energy production and increased mitochondrial oxidative damage are considered early pathological events that lead to neurodegeneration.
Impairment of mitochondrial metabolism results in damage to existing proteins and DNA.
Impairment of PQC plays a prominent role in the pathophysiology of ageing-related neurodegenerative disorders such as Parkinson's , Huntington׳s , and Alzheimer׳s disease.
Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing.
Impairment of the orienting network was found to be insignificant.
Impairments accumulated over multiple physiologic systems may make older adults more vulnerable to slow gait speed.
Impairments in both gait and cognition are prevalent in older adults.
Impairments in insulin-mediated microvascular perfusion in muscle can directly cause insulin resistance , and this event can occur early in the aetiology of this condition.
Impairments in learning and recall have been well established in amnestic mild cognitive impairment ( aMCI ) .
Impairments in microvascular structure and / or function with aging and type @number@ diabetes have been associated with the progressive loss of skeletal muscle mass.
Impairments in protein quality control ( PQC ) may lead to degenerative processes , such as aging and various disorders and diseases.
Impairments in the medial temporal gyrus and hippocampus may serve as important markers distinguishing MCI from healthy aging.
Impairments in the @number@ domains increased subsequent disability with hypertension ( P < 0.0001 ) .
Impairments in these fish arise in the skin , muscle and adipose tissue , and sometimes in the cartilage.
Impairments in this pathway are implicated also in synaptic dysfunction in Alzheimer's disease , Down syndrome , epilepsy , and normal aging.
Impairments of taste and smell perception in elderly people can lead to reduced enjoyment of food and contribute to the anorexia of aging.
Impairments of the vestibular-ocular reflex ( VOR ) lead to a decline in visual acuity during head movements.
Impedance change was greatest at frequencies < 10 Hz , and smallest at frequencies @number@ kHz and above.
Implantable CGM systems may provide additional benefits.
Implantable implantation has become established as an effective secondary prevention for SCD , and numbers have been increasing annually worldwide.
Implant arthroplasty typically can improve pain but does not reliably improve range of motion , and complication and revision rates are substantial.
Implantation rate decreases and miscarriage rate increases with advancing maternal age.
Implanted matrigel plugs containing VEGF in REGγ ( - / - ) mice induced fewer capillaries than in REGγ ( + / + ) littermates.
Implant placement was preperitoneal in @number@ patients and retromuscular sublay in five.
Implementation assistance should be targeted to nonadopters , particularly those who never or infrequently work alongside physicians and those in rural hospitals.
Implementation at a larger scale is warranted.
Implementation costs were low.
Implementation of guidelines and restriction of filler use by trained physicians can improve safety for patients.
Implementation of novel rehabilitation models is critical to help patients manage their illness.
Implementation of RBC microparticles as biomarkers in the laboratory routine needs to overcome technical barriers involved in their analysis.
Implementation of stereotactic radiosurgery and increased brachytherapy treatments explain much of the increased workload.
Implementation of such tests may facilitate early and potentially more effective therapeutic and preventative strategies for AD.
Implementation of the Affordable Care Act ( @number@ ) enabled more than @number@ million people to have new access to primary care services.
Implementation of the results of the study is recommended in management of anti-cancer activities for laryngeal cancer.
Implementation of the US Resident Assessment Instrument reduced dehydration prevalence from @percent@ to @percent@ , P = @number@
Implementation proved to be difficult in terms of study recruitment and intervention acceptance and adherence.
Implementing evidence-based behavioral interventions ( EBIs ) to prevent and manage chronic disease and disability in community settings could help ameliorate disparities.
Implementing quantitative ADL measurements could enable more appropriate and individual care for the elderly.
Implementing this strategy requires a better understanding of genetic and non-genetic connections among aging , health , and longevity.
Implementing vaccination recommendations for the elderly by STIKO can reduce burden of infectious diseases by prevention of infection or reduction of severity of infection.
Implicated factors may include demographic and socioeconomic aspects , tumor biological characteristics , and access to medical care.
Implicating lipid genes in exceptional longevity may lead to drug therapies that prevent several age-related diseases , with such efforts already on the way.
Implication of this study for organizational practice was discussed.
Implications.
IMPLICATIONS : According to social capital theory , social networks provide a vehicle for social resources that can be beneficial for successful aging and well-being.
IMPLICATIONS : Accurate PA assessment during the winter months must account for the ambient daytime high temperatures , humidity , and time of day.
IMPLICATIONS : A life-course perspective , and qualitative and quantitative data facilitate understanding the care journeys-health and service trajectories of older women with dementia.
IMPLICATIONS : Although a health disparate population , good health among LGBT older adults appears to be attained via multiple resilience and risk pathways.
IMPLICATIONS : Among older adults who experienced a fall and hospitalization , odds of mortality appear influenced by factors beyond injury severity related to falling.
Implications and recommendations for future HIV / AIDS research and intervention targeting midlife and older women are presented.
Implications and suggestions for structuring learning opportunities that combine community health promotion practice and interprofessional learning are discussed.
IMPLICATIONS : An imbalance between activation and inhibition of the complement system has been implicated in the etiologies of numerous common diseases.
Implications : Approaches that combine participatory geospatial and qualitative methods are beginning to emerge in the aging literature.
Implications are discussed.
Implications are discussed.
Implications are discussed for building capacity within ethnic communities to address living arrangement preferences and their repercussions for caregiving in ethnic families and in communities.
Implications are discussed , in particular , regarding the interdependency of subjective organization and verbal learning in old age.
Implications are discussed regarding the well-being paradox and the yet unclear mechanisms that link evaluative indicators to the dying process.
Implications are provided for enhanced assessment and intervention of the elderly high in neuroticism , depression , hopelessness , and with negative self-other perception.
IMPLICATIONS : Because of population aging and social service organizational contraction , humanitarian service organizations may rely more on older volunteers to fulfill their goals.
IMPLICATIONS : Combination therapy with AS101 and paclitaxel has novel therapeutic potential targeting deregulated active pathways in lymphoma , overcoming endogenous resistance to apoptosis.
IMPLICATIONS : Definitions of a good old age provided by the oldest old themselves give new insights into the concept of successful aging.
IMPLICATIONS : Depression diagnosis and symptomatology are jointly associated with health care engagement among LGBT older adults.
IMPLICATIONS : Despite the potential benefits of planning for DRC , families are unsure about how best to approach this topic.
IMPLICATIONS : Despite the significant cultural and linguistic barriers , Chinese Americans can be successfully recruited into longitudinal studies of aging and cognitive impairment.
Implications drawn from theory and application are discussed.
IMPLICATIONS : DYRK1B is a promising and novel kinase target for prostate cancer treatment mediated by enhancing NKX3.1 levels.
IMPLICATIONS : End-of-life care for the burgeoning inmate population is costly , and active life-sustaining treatments may not be desired under certain conditions.
IMPLICATIONS : Engagement in a varied range of activities benefits mental health among elders more than participation in any single type of activity among elders.
IMPLICATIONS : Findings highlight that research gains from a phenomenological understanding of how religious faith promotes generative cognitions and emotions.
IMPLICATIONS : Findings suggest older parents ' perceptions of supporting their offspring may condition how generativity affects their mental health.
Implications for assessment , access to care , and group-specific services delivery are discussed.
Implications for assessment and treatment are discussed.
Implications for best practice include attention to culturally responsive outreach , motivating with social support and incentives , and developing community-based culturally compatible programming.
Implications for clinical nursing forensic practitioners operating within different service frameworks are discussed.
Implications for clinicians and future studies are discussed.
Implications for creation of normative data are discussed.
Implications for developing more complex models of the relationship between stress , social support and psychological distress are discussed.
Implications for employee selection and adverse impact on older job candidates are discussed.
Implications for facial rejuvenation surgery are discussed.
Implications for future research and practice are considered.
Implications for future research and prevention efforts are discussed.
Implications for future use of both scales are discussed.
Implications for health professionals , local community centres and other potential service providers are discussed.
Implications for improving the success rates of MRI with older adults are discussed.
Implications for individual- and country-level strategies for successful aging are discussed.
Implications for long-distance caregiving communication are discussed.
Implications for mobilizing community action to promote aging with dignity and independence are discussed.
Implications for models of self-regulated learning are discussed.
IMPLICATIONS FOR NURSING MANAGEMENT : Nurse Managers must participate in design efforts and advocate designs that support aging nurses.
IMPLICATIONS FOR NURSING MANAGEMENT : The HEALE curriculum sets a standard for best practices in nursing management and for LGBT cultural competency in geriatric education.
Implications for nursing practice are provided.
Implications for nursing research and practice are posited.
Implications for organismal aging are discussed.
Implications for patient health outcomes and healthcare costs are discussed.
Implications for policy and practice and recommendations for future research are also discussed.
Implications for policy and practice are discussed.
Implications for practice and research are provided.
Implications for practice are discussed.
Implications for practice are discussed.
IMPLICATIONS FOR PRACTICE : Early screening has the potential to identify either nutritional risk or nutritional decline in older adults.
IMPLICATIONS FOR PRACTICE : Graduates identified a need for more educational content and clinical experiences specific to the care of older adults.
IMPLICATIONS FOR PRACTICE : Nurses can play a vital role in minimising social isolation through a variety of educational , prevention and political lobbying activities.
IMPLICATIONS FOR PRACTICE : Nurses need to be encouraged to share their important perspective about older adult care.
IMPLICATIONS FOR PRACTICE : The Theory of Finding Home gives insight into what matters to older people living in long-term care settings.
Implications for preventing homebound status and mitigating its impact with regards to the Israeli context are discussed.
IMPLICATIONS FOR REHABILITATION : Fall-related behaviors should be addressed in the assessment of community-dwelling seniors ' fall risks.
IMPLICATIONS FOR REHABILITATION : Identity and social engagement are important social factors that play a role in community mobility.
Implications for research and clinical work are discussed.
Implications for research and practice are discussed.
Implications for research and the design of instructional materials to increase people's knowledge about normative changes in adult cognition are discussed.
Implications for research methods and practise of health stabilisation are discussed.
Implications for research on psychological resilience , pain catastrophizing , and positive emotions are discussed.
Implications for senior programs and policies are discussed.
Implications for service delivery and policy are discussed.
Implications for social work practice are discussed.
Implications for social work practice include exploring perceptions of family members regarding patterns and using the concept of ambivalence to normalize sibling relationships.
Implications for stigma and stress research are discussed.
Implications for the broader application of cognitive training interventions are discussed.
Implications for the development of intervention strategies that target preservation of functional independence in older adults are discussed.
Implications for the experience of ambivalence and conflicts as well as well-being of family members from both generations will be discussed.
Implications for the field of volunteerism are discussed.
Implications for theories of long-term memory are discussed.
Implications for theory and practice highlight an inherent limitation in randomized controlled trials insofar as they may compromise participants ' group identification.
Implications for theory , method and practice are discussed.
Implications for these findings are discussed in terms of adult intellectual development and maintenance.
Implications for these findings on nursing practice and research are posited.
Implications for understanding age-related stereotypes and conceptions of wisdom are discussed.
Implications for understanding emotions across the life span are discussed.
Implications for workforce planning and public policy are discussed.
Implications from these model studies on the design of clinical trials are discussed herein.
IMPLICATIONS : Governments are lagging behind sociodemographic and social change.
IMPLICATIONS : Historical and environmental contexts frame normative and non-normative life events.
IMPLICATIONS : In acute anticoagulation use apixaban was found to be cost-saving.
IMPLICATIONS : Individual and structural-environmental characteristics contributed to resilience and mastery.
IMPLICATIONS : In older , community-resident disabled women , baseline levels of social support did not consistently predict diet quality.
IMPLICATIONS : It is premature to recommend caregiver interventions based on our unexpected findings.
IMPLICATIONS : Knowledge about differing network types should make gerontological practitioners more aware of the varying interpersonal milieus in which older people function.
Implications , limitations , and future research directions are discussed.
Implications of a balanced time perspective on mental health over the life course are discussed.
Implications of and recommendations for incorporating a valid depression-screening tool into social service agencies ' existing assessment process are discussed.
Implications of the current analysis on the in vitro-in vivo extrapolation of transporter-mediated drug disposition using physiologically based pharmacokinetic models are discussed.
Implications of the findings for economic socialization are discussed.
Implications of the findings for enhancing resources to more fully support the @percent@ of caregivers that are caring for non-kin are discussed.
Implications of the findings to social work education are discussed.
Implications of the results for interpreting age differences in PI and false memory are discussed.
Implications of these data for current views on memory remediation in cognitively impaired older adults are discussed.
Implications of these findings are discussed.
Implications of these findings are discussed.
Implications of these findings are discussed in further detail.
Implications of these findings , especially for neuropsychological studies on source monitoring , are discussed.
Implications of these findings for the understanding of the well-being paradox are discussed.
Implications of these findings on a theoretical and methodological level are discussed , and potential consequences for applied settings are considered.
Implications of these results are discussed and suggestions are made for future research.
Implications of these results are discussed from a continuity theory and life course perspective.
Implications of these results for models of practiced dual tasks are discussed.
Implications of this research for improving prevention , assessment , and intervention in audiologic practice and for enhancing interprofessional teamwork are highlighted.
Implications of this research include the importance of making provision for our aging population and ensuring that preventative care is available to all.
Implications of this , with respect to the stability of the undifferentiated state and long-term differentiation potential of iPSCs , warrant further studies.
IMPLICATIONS : Our findings indicate that greater cultural identity and engagement in traditional healing practices are related to caregiving in American Indian populations.
IMPLICATIONS : Participants ' explanatory models for osteoporosis are substantively different than clinical models.
IMPLICATIONS : Partnerships with CBOs were critical for reaching the target enrollment for our studies.
IMPLICATIONS : Productive activities-and frequent volunteering in particular-may protect individuals from inflammation that is associated with increased risk of hypertension and cardiovascular disease.
IMPLICATIONS : Racial differences varied by generation ( parent or offspring ) .
IMPLICATIONS : REAL improves skills in everyday problem solving , which may allow AL residents to maintain self-care and extend AL residency.
IMPLICATIONS : Recruiting and retaining minority or poor research participants is challenging but possible.
IMPLICATIONS : Results demonstrate associations between @number@ methods of assessing functional status and suggest proxy reports are generally more accurate than self-report measures.
IMPLICATIONS : Rituximab administered in the form of subcutaneous injection is less costly than its intravenous form.
IMPLICATIONS : Self-reports of relational aggression seem to be better predictors of resident's well-being than nurse-reports of relational aggression.
IMPLICATIONS : Sensory-processing abilities among older persons and their relation to occupational engagement in various life settings should receive attention in research and practice.
IMPLICATIONS : Technology usage in U.S. older adults varied significantly by sociodemographic and health status.
IMPLICATIONS : The development of quantitative surrogate end points remains necessary to improve the development of AD drugs.
IMPLICATIONS : The \ "do-it-yourself \ " approach to retirement planning-with individuals managing a large portion of their retirement finances-is now common among older Americans.
IMPLICATIONS : The evolving American health care system may increase service availability.
IMPLICATIONS : The findings provide direction on how leaders can facilitate function-focused care in the current health-care environment emphasising system efficiency.
IMPLICATIONS : The findings suggest that Medicaid HCBS waiver programs may reduce the prevalence of low-care residents in NHs.
IMPLICATIONS : The GHCC-COAH partnership demonstrates how academic-community partnerships can serve as an engine for social innovation.
IMPLICATIONS : The high level of clinical significance suggests that CGGT participants were effectively treated for CG.
IMPLICATIONS : The NYUCI-AC offered adult child caregivers counseling and support that improved their ability to manage their reactions to disruptive behaviors.
IMPLICATIONS : The prevalence of homophobic attitudes among older people living in RACFs seems to be high.
IMPLICATIONS : The proposed standards provide easy-to-use , previously unavailable methods for evaluating physical capacity in older adults relative to that associated with physical independence.
IMPLICATIONS : The results indicate the significance of the childhood environment for understanding loneliness in later life.
IMPLICATIONS : The results suggest that positive intergenerational interaction leads to generativity development and better well-being in old age.
IMPLICATIONS : The study provides a description of annual care transition patterns across six years.
IMPLICATIONS : This study demonstrates that ethnic differences exist in the ownership of LTCI among elderly Americans.
IMPLICATIONS : This study indicates that retirees experienced a new stage of \ "Redirection \ " and found new meaning through volunteer work during retirement.
IMPLICATIONS : Unique social network types ( diverse / no children and friend-centered / restricted ) emerge among LGBT older adults.
IMPLICATIONS : Unrealistically high or low ERA could negatively influence the quality of care provided to patients and patients ' own age expectations.
IMPLICATIONS : Weekly CST with or without carer training may not be an effective form of delivery.
IMPLICATIONS : WheelSeeU provides an innovative approach for teaching wheelchair skills to an aging population that may improve wheelchair use and decrease clinician burden.
IMPLICATIONS : Women aging with HIV experience social participation as a dynamic process involving social engagement and isolation.
Implicit association tests ( IATs ) are increasingly used to indirectly assess people's traits , attitudes , or other characteristics.
Implicit barriers to sleep were found when participants responded to open-ended questions.
Implicit learning did occur under time constraints that prevented explicit learning.
IMPORTANCE : Additional information is needed about the role of dietary sodium on health outcomes in older adults.
IMPORTANCE Advanced glycation end products have been implicated in the pathogenesis of age-related macular degeneration ( AMD ) .
IMPORTANCE : Age-related hearing loss affects quality of life.
Importance : Alteration of ex vivo magnetic resonance imaging transverse relaxation is associated with late-life cognitive decline even after controlling for common neuropathologic conditions.
IMPORTANCE : Alzheimer disease ( AD ) is a neurodegenerative disorder with no effective therapies.
IMPORTANCE : Associations have been documented between physical activity and depressive symptoms , but the direction of this association is unclear.
Importance : Cancer is the second leading cause of death worldwide.
Importance : Cataract , one of the most frequent causes of blindness in developed countries , is strongly associated with aging.
IMPORTANCE : Cataracts are a main cause of low vision ; with the growing elderly population , the incidence of cataracts is likely to increase.
Importance : Changes in behavior and personality are @number@ criterion for the diagnosis of dementia.
IMPORTANCE : Cognitive decline is a common and feared aspect of aging.
IMPORTANCE : Cognitive decline is a leading cause of disability and death in old age but its neurobiological bases are not well understood.
Importance : Comprehensive and timely monitoring of disease burden in all age groups , including children and adolescents , is essential for improving population health.
IMPORTANCE : Considerable advances have been made in our understanding of the genetics underlying amyotrophic lateral sclerosis ( ALS ) .
IMPORTANCE : Criteria for preclinical Alzheimer disease ( AD ) propose β-amyloid ( Aβ ) plaques to initiate neurodegeneration within AD-affected regions.
Importance : Data describing the effects of weight gain across adulthood on overall health are important for weight control.
IMPORTANCE : Delirium , an acute disorder with high morbidity and mortality , is often preventable through multicomponent nonpharmacological strategies.
Importance : Delirium is defined as an acute disorder of attention and cognition.
IMPORTANCE : Diabetes is associated with an elevated risk of coronary heart disease ( CHD ) .
Importance : Dichotomous dermatologic depictions of heroes and villains in movies have been used since the silent film age.
IMPORTANCE : Epidemiological evidence suggests that physical activity benefits cognition , but results from randomized trials are limited and mixed.
IMPORTANCE : Epidemiologic evidence regarding the importance of traumatic brain injury ( TBI ) as a risk factor for dementia is conflicting.
Importance : Evidence quantifying the influence of face-lift surgery on societal perceptions is lacking.
IMPORTANCE : Facial erythema and telangiectasia are commonly associated with the erythematotelangiectatic subtype of rosacea ( ETR ) .
Importance : Health care spending in the United States increased substantially from @number@ to @number@ and comprised @percent@ of the economy in @number@
Importance : Hearing impairment ( HI ) is highly prevalent in older adults and has been associated with adverse health outcomes.
IMPORTANCE : Hypertension is common among people older than @number@ years , affecting nearly two-thirds of men and three-fourths of women by age @number@ years.
Importance : In advanced dementia , goals of care decisions are challenging and medical care is often more intensive than desired.
IMPORTANCE : Increased pulse pressure associated with age-related arterial stiffening increases risk for Alzheimer dementia but the mechanism responsible for this association remains unclear.
Importance : In one-third of older men with anemia , no recognized cause can be found.
IMPORTANCE : Intellectual lifestyle enrichment throughout life is increasingly viewed as a protective strategy against commonly observed cognitive decline in the older population.
IMPORTANCE : In the coming decades , the population of older adults with type @number@ diabetes mellitus is expected to grow substantially.
IMPORTANCE : In vivo imaging of brain β-amyloid , a hallmark of Alzheimer disease , may assist in the clinical assessment of suspected Alzheimer disease.
IMPORTANCE : In youth , facial aesthetic units flow together without perceptible division.
Importance : Low income has been associated with poor health outcomes.
Importance : Measurement of ganglion cell complex ( GCC ) thickness may be more sensitive than current methods for glaucoma diagnosis and research.
IMPORTANCE : Measures of neuronal loss are likely good surrogates for clinical and radiological disease progression in Alzheimer disease ( AD ) .
IMPORTANCE : Microneedle therapy includes skin puncture with multiple micro-sized needles to promote skin rejuvenation or increase transdermal delivery of topical medications.
IMPORTANCE : Milk consumption during adolescence is recommended to promote peak bone mass and thereby reduce fracture risk in later life.
IMPORTANCE : More than one-third of all US inpatient operations are performed on patients aged @number@ years and older.
IMPORTANCE : Morphometric assessment has emerged as a strong predictor of postoperative morbidity and mortality.
Importance : Most cognitive functions decline with age.
IMPORTANCE : Myasthenia gravis is a chronic , autoimmune , neuromuscular disease characterized by fluctuating weakness of voluntary muscle groups.
IMPORTANCE : Observational studies indicate that lower blood pressure ( BP ) increases risk for cognitive decline in elderly individuals.
IMPORTANCE : Older adults commonly report disturbed sleep , and recent studies in humans and animals suggest links between sleep and Alzheimer disease biomarkers.
Importance : Older patients undergoing abdominal surgery commonly experience preventable delirium , which extends their hospital length of stay ( LOS ) .
Importance : Osteoporotic fractures are a leading cause of disability , costs , and mortality.
IMPORTANCE : Our findings that the generational age of Cryptococcus neoformans cells matters in pathogenesis introduces a novel concept to eukaryotic pathogenesis research.
Importance : Oxidative stress is an established dementia pathway , but it is unknown if the use of antioxidant supplements can prevent dementia.
IMPORTANCE : Parkinsonian motor signs are common in the aging population and are associated with adverse health outcomes.
Importance : Pelvic organ prolapse is a common condition , the prevalence of which is likely to increase with the aging of our population.
IMPORTANCE : Peripheral glucose homeostasis has been implicated in the pathogenesis of Alzheimer disease ( AD ) .
Importance : Photoaging , which is premature skin aging caused by long-term UV exposure , is of aesthetic concern to many patients.
Importance : Pigmented facial macules on photodamaged skin are a clinical , dermoscopic , and histopathologic challenge.
IMPORTANCE : Prevention of atherosclerotic cardiovascular diseases is an important public health priority in Japan due to an aging population.
IMPORTANCE : Recently , a rare variant in the amyloid precursor protein gene ( APP ) was described in a population from Iceland.
Importance : Recent studies have yielded conflicting results as to whether testosterone treatment increases cardiovascular risk.
Importance : Research in facial aging has focused on soft-tissue changes rather than bony changes despite evidence of the importance of underlying bony structural changes.
IMPORTANCE Rib cartilage from the sixth , seventh , and eighth ribs offers a long cartilaginous curvature , making the material reliable for grafting.
Importance : Schizophrenia is associated with widespread cognitive impairments.
IMPORTANCE : Screening for osteoporosis with bone mineral density ( BMD ) is recommended for older adults.
IMPORTANCE : Solar UV irradiation causes photoaging , characterized by fragmentation and reduced production of type I collagen fibrils that provide strength to skin.
Importance : Surgical procedures for the aging face-including face-lift , blepharoplasty , and brow-lift-consistently rank among the most popular cosmetic services sought by patients.
IMPORTANCE : Telomeres protect chromosome ends and are markers of cellular aging and replicative capacity.
IMPORTANCE : Testosterone use in older men is increasing , but its long-term effects on progression of atherosclerosis are unknown.
Importance : The accumulation of aggregated β-amyloid and tau proteins into plaques and tangles is a central feature of Alzheimer disease ( AD ) .
Importance : The effect of childhood epilepsy on later-life cognitive and brain health is an unclear and little-explored issue.
IMPORTANCE : The effect of obesity on late-age survival in women without disease or disability is unknown.
IMPORTANCE : The extended longevity of modern humans is a very recent societal artifact , although it is inherent in human evolution.
Importance : The frequency of cancers with indolent behavior has increased with screening.
IMPORTANCE : The Healthy Brain Initiative 2013-2018 seeks to optimize brain health as we age.
Importance : The issue of the aging physician and when to cease practice has been controversial for many years.
Importance : The market for nonsurgical , energy-based facial rejuvenation techniques has increased exponentially since lasers were first used for skin rejuvenation in @number@
IMPORTANCE : The neurobiologic basis of late-life depressive symptoms is not well understood.
Importance : The prevalence of cerebral cavernous malformation ( CCM ) is unknown.
IMPORTANCE : There are genetic influences on memory ability as we age , but no specific genes have been identified.
IMPORTANCE : The reconstruction of cutaneous defects of the cheek and lip is a foundational topic for facial plastic and reconstructive surgeons.
IMPORTANCE The search for novel Alzheimer disease ( AD ) genes or pathologic mutations within known AD loci is ongoing.
Importance : The utility of plasma total tau level as a prognostic marker for cognitive decline and dementia is not well understood.
IMPORTANCE : This study assesses factors associated with the most common adverse event following lumbar puncture.
IMPORTANCE : To our knowledge , no previous epidemiologic study has investigated the association between all antioxidants in the diet and age-related cataract.
Importance : Trends in dementia incidence rates have important implications for planning and prevention.
IMPORTANCE : Typical cognitive aging may be defined as age-associated changes in cognitive performance in individuals who remain free of dementia.
IMPORTANCE : Use of aspirin and other nonsteroidal anti-inflammatory drugs ( NSAIDs ) is associated with lower risk of colorectal cancer.
IMPORTANCE : With an aging population , preoperative assessment of the frail older adult requires evaluation beyond simply accounting for chronic diseases.
IMPORTANCE : With increasing age , the immune system undergoes drastic changes , and older individuals have declined resistance to infections.
IMPORTANCE : α-Synuclein ( SNCA ) locus duplications are associated with variable clinical features and reduced penetrance but the reasons underlying this variability are unknown.
Important areas not addressed to any major degree were healthcare costs and genetics.
Important comorbidities are psoriatic arthritis , metabolic syndrome , Crohn's disease , depression , and cancer.
Important consequences of osteoporotic fractures include an increased mortality that for hip fractures extends to @number@ years after the fracture.
Important disease-associated factors determine the balance of cytokine responses.
Important ethnic and racial differences are also mentioned.
Important findings in the last decade have revealed that neurogenesis is not the stand-alone consideration in the fight for full functional recovery from stroke.
Important influential factors include the age at which menopause occurs , personal health and wellbeing , and each woman's environment and culture.
Importantly , after controlling for age , diffusion measures predicted cognitive function in a region-specific way that was also influenced by ε4 status.
Importantly , after selecting an item , children were queried about their memory for the problem.
Importantly , aged mice given PspA plus a combination of pFL and CpG ODN showed protective immunity against nasal S. pneumoniae colonization.
Importantly , although progerin was detected at higher rates in the HGPS coronary arteries , it was also present in non-HGPS individuals.
Importantly , among many inflammation-associated factors , the aged rat liver showed chronically increased IL-1β production.
Importantly , analysis of human tumor samples suggests that LKB1 mutational status could be a prognostic risk factor for UV-induced skin cancer.
Importantly analyzing the stretched exponents would help in evaluating the heterogeneity trends in human populations.
Importantly , an LTC system should be established in China as soon as possible.
Importantly , a polymorphism in the XBP1 promoter was suggested as a risk factor to develop AD.
Importantly , APP / AICD increases PGC-1α expression also in the mice brain.
Importantly , a small amount of preformed apoA-I fibrils was able to seed amyloid formation in oxidized apoA-I at pH @number@
Importantly , autophagy was also involved in this process , as supported by the appearance of a punctuate LC3 pattern and autophagic vacuoles.
Importantly , a young uterine environment can restore normal placental as well as embryonic development.
Importantly , being exposed to lifting increased the risk of disability pension.
Importantly , both bioenergetics and redox homeostasis are coupled to neuro-glial central carbon metabolism.
Importantly , both mice displayed an age-related entorhinal cortex thinning and robust striatal atrophy , the latter associated with a significant loss of synaptophysin.
Importantly , both the Pin1 WW domain and isomerase activity are required for its effect on S-phase checkpoint.
Importantly , cell-permeable Pin1-FOXM1-blocking peptides repressed the proliferation of melanoma cells in freshly isolated human metastatic melanoma ex vivo and in patient-derived melanoids.
Importantly , cerebral activity during early learning can differentially predict the amplitude of the training-induced performance benefit between young and older adults.
Importantly , changes in hormone production and signaling have direct effects on brain function and the development of age-related neurologic disorders.
Importantly , clearer conceptual models of activity broadly conceived are required to guide this work.
Importantly , cognitive reserve is not fixed but continues to evolve across the lifespan.
Importantly , conditioning steps may be needed to reverse exposure memory and enable effective regeneration.
Importantly , Cys113-oxidized Pin1 is significantly increased in human AD brain comparing to age-matched controls.
Importantly , deceleration of aging can in turn postpone cancer , which is an age-related disease.
Importantly , embryonic stem cell lines with capacity to differentiate into tissues from all germ layers were derived from SCNT blastocysts obtained from climacteric ooplasts.
Importantly , endpoint mtDNA copy number was significantly correlated with age.
Importantly , environmental conditions are thought to modulate the aging process.
Importantly , ET-1 expression was markedly upregulated in P30 ( vs. P3 ) fibroblasts.
Importantly , even after adjustment for age and BMI , many inflammatory markers continued to be associated to multi-morbidity.
Importantly , exogenous HA was incorporated into fine HA filaments of the pericellular fibroblast matrix.
Importantly , fallers with COPD had significantly worse Rhythm than nonfallers with COPD.
Importantly , fatty liver may be a novel metabolic risk factor in overweight and obese individuals.
Importantly , for heterozygotes , the apoE4 / apoE3 isoform ratio was increased in the CNS , although the reverse was true in the periphery.
Importantly , FOXO factors can also positively regulate cell survival through the activation of several detoxification genes , complicating its putative therapeutic potential.
Importantly , functional improvement and goal attainment did not vary by demographics or diagnoses.
Importantly , genetic mutations that enhance longevity significantly delay the loss of synaptic connectivity and , therefore , the onset of age-related brain disorders.
Importantly , GEPCI-determined changes in the hippocampal tissue cellular integrity were detected even in the hippocampal areas not affected by the atrophy.
Importantly , glycosylated hemoglobin levels were not related to performance on either implicit or explicit memory tasks.
Importantly , histological and immunohistochemical results in the brain showed that PSE supplementation may have a neuroprotective effect that alleviates neuroinflammation in aged rats.
Importantly , however , a divergent pattern was observed subcortically.
Importantly , however , although hippocampal neurogenesis is maintained all throughout life , its levels decrease steadily along with aging.
Importantly , IL-17 neutralization or neutrophil depletion during viral infection reduced liver damage and prevented death of aged mice.
Importantly , in amyloid-negative patients with MCI , SPARE-AD had high predictive power of clinical progression.
Importantly , in control cardiomyocytes , lowering ROS levels emulated this beneficial effect of PGC-1α knockdown and similarly increased the calcium transient amplitude.
Importantly , individual differences showed that the older participants who used a spatial strategy to solve the task had significant activity in the hippocampus.
Importantly , individuals with these conditions have shown improved leg power with training.
Importantly , induced expression of SLP-2 corrected for these mitochondrial alterations caused by reduced Parkin function in these cells.
Importantly , inhibition of Rho activity in senescent ECs significantly reduced cell stiffness and MAC-induced lysis.
Importantly , inhibition of TGFbeta @number@ by a neutralizing antibody abolished the effect of mandibuloacral dysplasia type A conditioned medium on osteoclast differentiation.
Importantly , in some cases , a minor subclone contributed to relapse , suggesting the strategies to assess clonal heterogeneity are needed to optimize therapy.
Importantly , inter-subject differences were extremely large.
Importantly , it has been suggested that lncRNAs can regulate chromatin alteration , messenger RNA stability , microRNA action , and can control transcription factors.
Importantly , it is becoming apparent that these same mechanisms when deregulated also result in the development of age-related disease.
Importantly , it is unknown whether smoking-related brain changes are reversible after smoking cessation.
Importantly , it is well known that when these mechanisms dysregulate it results in the development of age-related disease.
Importantly , its overexpression suppresses insulin / IGF-1 signaling and thus extends the lifespan.
Importantly , kinetic tests indicated that the binding to PIR-B of Nogo and MHCI was competitive.
Importantly , KL increases phagocytosis in cultured RPE by inducing gene expression of MERTK / AXL / TYRO3.
Importantly , knockdown of Notch target gene Hes1 totally blocked the inhibition effect of Jagged1 on cellular senescence.
Importantly , Lamin A / C reintroduction reduced cell growth kinetics and impaired migration , invasion , and anchorage-independent cell growth.
Importantly , level @number@ anticholinergics have been identified as major contributors to the anticholinergic load in people with dementia.
Importantly , loss of p16 ( INK4a ) is one of the most frequent events in human tumors and allows precancerous lesions to bypass senescence.
Importantly , lower positive processing at age @number@ predicted increased symptoms at age @number@
Importantly , market-based trading protected older adults with lower caudate volume to a greater extent from their own poorly calibrated predictions.
Importantly , most of the adaptations to training occurred independent of age.
Importantly , most of these associations remained significant even after excluding subjects with aldosterone levels above the normal range.
Importantly , MultiTEP platform enables development of vaccines targeting pathological molecules involved in various neurodegenerative disorders.
Importantly , NDI is more sensitive to such developmental changes compared to commonly used DTI metrics.
Importantly , neither PFC nor parieto-occipital reorganizations prevented older participants from showing worse WM performance than young volunteers.
Importantly , no approved therapies are available to treat HFpEF.
Importantly , not all wavelengths of light are equally chronodisrupting.
Importantly , older adults remembered more negative information in the choice condition compared with younger adults.
Importantly , older adults who were interviewed with a Modified Cognitive Interview were not susceptible to misinformation effects.
Importantly , older athletes lose their PV advantage , as compared with young athletes.
Importantly , older individuals did not have an impaired response to MSC therapy.
Importantly , oligoclonal expansions of these cells are associated with increased morbidity and mortality risk in elderly humans.
Importantly , OLR1 and PDGFRβ were associated in close proximity in the plasma membrane.
Importantly , our findings suggest that developmental dissociations in these three EF components do not emerge until children transition into adolescence.
Importantly , our results also show that speech skills in aging are affected by changes in cortical thickness and in brain functioning.
Importantly , oxidative protein damage contributes to age-dependent accumulation of dysfunctional mitochondria or protein aggregates.
Importantly , polyubiquitin chains at sites of DNA damage remained for longer periods in USP5-depleted cells.
Importantly , PS1-FAD mutations decreased PS1's ability to enhance PGC-1α mRNA levels.
Importantly , RA significantly reduced CCN1 expression in skin equivalent cultures.
Importantly , recent evidence shows that having an ' older'-appearing brain relates to advanced physiological and cognitive ageing and the risk of mortality.
Importantly , recent studies indicate dietary flavonoids have anti-inflammatory properties and are capable of mitigating microglial cells in the brains of aged mice.
Importantly , relative to young adults , older adults demonstrated better calibration both on item-by-item confidence judgments and on global estimates.
Importantly , respondents with higher distress and greater computer literacy were more likely to consider mental health treatments delivered via the Internet.
Importantly , results from both tasks indicated that higher levels of tau and phosphorylated tau pathologies were associated with block-level overactivations of attentional control areas.
Importantly , Runt-related transcription factors , particularly Runx1 and Runx3 , interplay with these master regulators in various aspects of T cells ' immunity.
Importantly , satisfaction reports also indicate that caregivers overcame the barriers to participation , and had a strong sense of the group's presence.
Importantly , schizophrenia patients failed to display this developmental trend in the same age range and adults had significant deficits compared to the control group.
Importantly , several neurodegenerative diseases are characterized by cytoplasmic \ "solid \ " aggregates formed by mainly nuclear RBPs harboring LC prion-like domains.
Importantly , significantly decreased negative functional connection may be specifically associated with the development of aMCI patients.
Importantly , silencing CircPVT1 promoted cell senescence and reversed the proliferative phenotype observed after let-7 function was impaired.
Importantly , SIRT1 is a regulator of aging , inflammation and metabolism.
Importantly , SIRT4 catalytic efficiency for lipoyl- and biotinyl-lysine modifications is superior to its deacetylation activity.
Importantly , SIRT7 suppresses ER stress and reverts the fatty liver disease in diet-induced obese mice.
Importantly , S-nitrosylation of PTEN decreases its phosphatase activity , thus promoting cell survival.
Importantly , spermidine and resveratrol frequently affect the acetylation pattern in a similar fashion.
Importantly , step number and mean pause duration quantified stair-stepping while measuring different constructs than root mean square error.
Importantly , stroke survivors have more than twice the risk of subsequently developing dementia compared with people who have never had a stroke.
Importantly , studies on DR promise to reveal novel strategies to prolong healthspan and prevent age-related disorders in human beings.
Importantly , subacute treatment with the anti-inflammatory drug ibuprofen suppressed astrocyte activation and restored synaptic plasticity and memory function in advanced-aged mice.
Importantly , TARC-PE38 significantly reduced the PVLs in PBMCs obtained from asymptomatic carriers.
Importantly , Th17 cells were accumulated in the intratumor and peritumor regions.
Importantly , the absolute increase in 10-year actual coronary CS progression was significantly higher than that predicted.
Importantly , the absolute increase in 10-year actual coronary CS was significantly higher than that predicted.
Importantly , the abundance of these cells is directly correlated with increased morbidity and mortality in older persons.
Importantly , the adult neural stem cell niche integrates both local and systemic changes , reflecting the physiological state of the organism.
Importantly , the benefit of rest could not be explained by active rehearsal , but can be attributed to the promotion of consolidation-related activity.
Importantly , the conjugates display no cytotoxicity at a high concentration.
Importantly , the described protocol may be easily applied to cardiac and skeletal tissue of various animal models and human samples.
Importantly , the differential presence of DPP4 allowed flow cytometry-mediated isolation of senescent cells using anti-DPP4 antibodies.
Importantly , the effect of the AA-genotype on dementia / AD risk seems to act mostly through the interaction with APOE ϵ4.
Importantly , the effects of cognitive abilities and quad processes on IAT scores were not significantly moderated by participants ' age.
Importantly , the effects of sex and CMV were in part explained by age and infection with other herpesviruses.
Importantly , the effects of SORL1 variation on both white matter microstructure and gene expression were observed during neurodevelopmental phases of the human lifespan.
Importantly , the familial domain , which has not been explored in many existing SA models , emerged as a notable predictor.
Importantly , the influence of BN on CD was greater for individuals with the APOE epsilon4 allele compared to those without the allele.
Importantly , the left carotid adventitial VV directly correlated with age.
Importantly , the mesonephros and endolymphatic sac of human embryos also show evidence of senescence.
Importantly , the molecular mechanisms of arterial aging are also relevant to the pathogenesis of hypertension and atherosclerosis.
Importantly , the overall N1 amplitude , but not frequency-specific neural adaptation was correlated with the pass-band of the auditory filter.
Importantly , the pharmaceutical investigations of anti-aging and AD relevant medications have also been highlighted.
Importantly , there have been publications showing increased numbers of myeloid-derived suppressor cells in aged mice and humans.
Importantly , there is extensive interindividual variability in sympathetic vasoconstrictor nerve activity , even among healthy , young , normotensive people.
Importantly , the relationship between HRV and cancer-related fatigue was sizeable.
Importantly , there was no decrease in enzyme levels in the cortex , putamen , or cerebellum of AD.
Importantly , the risks of undiagnosed and uncontrolled hypertension are lower among those with larger social networks-if they discuss health issues with their network members.
Importantly , these age-related changes show higher inter-individual variability in older subjects.
Importantly , these alterations could reverse with regular physical activity.
Importantly , these BACE1-labeled dystrophic axons resided near to or in direct contact with blood vessels.
Importantly , these decompositions achieve dimensionality reduction via highly interpretable ways and generalize well to new data as shown via split-sample experiments.
Importantly , these effects were strongest for midlife individuals ( those in their 30s-50s ) as compared with individuals who were younger or older.
Importantly , these patterns of emotional dominance and slower rivalry rates for emotional-face / house pairs disappeared when the stimuli were inverted.
Importantly , the sequences of key proteins involved in AD pathogenesis are highly conserved between sheep and human.
Importantly , these regions show high levels of amyloid deposition in AD , and are both structurally and functionally vulnerable early in the disease.
Importantly , the specificity of this finding was underscored by the observation that there was no general decline in activation during anticipation.
Importantly , the study was carried out in conditions optimal for dual-task performance and task automatization.
Importantly , they were equally reduced in diabetic patients with and without complications ( P < 0.001 ) compared with CTRs.
Importantly , this coupling was significantly higher in elderly brains than in young brains , both for high and low MEPs.
Importantly , this cycling pathway is under stringent regulation by the cell redox state.
Importantly , this effect occurred for correct source decisions only.
Importantly , this effect was strongest at high performance monitoring demands and independent of motor response execution as well as theta power.
Importantly , this finding was qualified by revealing that the benefit only held true for specific types of intentions such as health and social intentions.
Importantly , this leverage is specific to higher eukaryotes and not seen in bacterial , archaeal , and lower eukaryotic SerRSs.
Importantly , this method allows to capture training-induced change in 1-RM , thus making possible assessing training's effectiveness and allowing its modification if necessary.
Importantly , this pattern was also present in younger adults with a history of remote mTBI.
Importantly , this pattern was observed for both trained and transfer tasks.
Importantly , this study shows that double-blinded , placebo-controlled , randomized treatment trials are possible in prion disease.
Importantly , those that also engage in physical activity have the highest lean mass across body mass index categories.
Importantly , TNF blockade in tumor-bearing , aged mice receiving IT displayed significant anti-tumor effects.
Importantly , transfected synthetic RNA oligonucleotides antagonistic to the miRNA candidate significantly enhanced VZV plaque growth rates.
Importantly , TRT does not increase the risk of prostate cancer.
Importantly , VDSP developed protocols for standardizing 25 ( OH ) D values from prior research based on availability of stored serum samples.
Importantly , we demonstrate that epigenetic biomarkers in blood can mirror age-related epigenetic signatures in target tissues for metabolic diseases such as adipose tissue.
Importantly , we detected a worst performance , in terms of reaction times , for older than young participants in the allocentric frames.
Importantly , we detected elevated levels of active EphA4 in human AD brains , where EphA4 activation is inversely correlated with SORLA / EphA4 association.
Importantly , we discovered that endocannabinoid / mGlu BACKGROUND AND PURPOSE : Ultrasound markers of carotid atherosclerosis may be related to cognitive status.
Importantly , we found BBR-induced activation of Nrf2 is AMPK-dependent , as either pharmacologically or genetically inactivating AMPK blocked the activation of Nrf2.
Importantly , we found that NAP1L1 promotes CSB-mediated remodeling by accelerating both activation and translocation.
Importantly , we have identified SirT1 as a transcriptional activator in the regulation of SMC gene programme.
Importantly , we identified attrition of ribosomal DNA repeats as a molecular marker for human aging.
Importantly , we observed the prediction of cognitive decline was improved by considering both high and low levels of Aβ42.
Importantly , we provide a conceptual framework for the cerebellum influencing age differences in performance , centered on the notion of degraded internal models.
Importantly , we try to characterize and compare the distinct features in different ethanol ( EtOH ) -induced neurodegenerative disease ( NDD ) models.
Importantly , WIPI-1 , an autophagy-relevant PI3P probe , still formed some puncta upon starvation-induced autophagy in Vps34 knockout MEFs.
Important physiologic factors that affect brain volume measures are also considered.
Important policy documents were also collected from key informants during the interviews.
Important potential outcomes are emerging across other domains including research-informed policy development and the generation of health benefits.
Important practical implications for emergency officials responding to vulnerable older adults in disaster situations are also provided.
Important risk factors for a complicated course were increasing age , poor medical condition and delirium risk VMS Frailty score.
Important sex-specific factors associated with each of these procedures should be considered to best serve the male cosmetic patient.
Important steps must be taken to address the sustainability of LTC.
Important though this principle is , there is debate on how to interpret the core concept of autonomy.
Important variations were observed in both the importance and achievement of criteria for adulthood according to gender and adult status.
Imposed rationing is characteristic of wartime governments , who seek to prevent the rich from gobbling up the resources left by the army.
Imposing spatial structure reduces , but does not eliminate , the advantage of asymmetric division over symmetric division.
IMP participants were significantly less lonely and more likely to be married , but had lower well-being.
Imprecise eye movement , or later noise introduced at the combination stage , could not explain the results.
Impression cytology was performed and samples stained with HLA-DR and IL6.
Improper folding leads to the deposition of misfolded proteins in cells.
Improved accuracy in the clinical diagnosis of AD is anticipated with the addition of molecular and structural biomarkers in the next generation of epidemiological studies.
Improved approaches are needed to assess bioavailability of hydrophobic organic compounds in contaminated soils.
Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future.
Improved communication has the potential to reduce symptom burden and improve quality of life.
Improved comparability between major laboratories would speed the development of better RBC storage systems.
Improved correlations have been developed for the four age groups by implementing this in vivo-based diffusion parameter as well as the Cunningham correction factor.
Improved data on the potential benefits and harms of statins are needed to inform decision making.
Improved education on appropriate photoprotection in children is vital.
Improved emotion regulation has been suggested to underlie these high levels of well-being.
Improved executive function after passive cycling may be a result of increases in cerebral blood flow.
Improved functional outcomes when compared with hemiarthroplasty must be balanced against the increased cost and limited life expectancy of patients with this injury.
Improved function was associated with longer duration of rehabilitation.
Improved health behaviours could strengthen hypertension control.
Improved identification , monitoring , and treatment of pain are urgent priorities to improve the health and quality-of-life for people with dementia.
Improved imaging techniques with higher resolution and new sequences with increased sensitivity to certain tissues lead to correlations.
Improved knowledge of perinatal cardiac changes in normal fetuses could facilitate better understanding of cardiac adaptation in normal and pathological pregnancies.
Improved means of assessing neuroplasticity in humans , including biomarkers for predicting and monitoring treatment response , are needed.
Improved medical , economic and socio-cultural conditions have increased life expectancy , especially for women.
Improved medical management , while decreasing mortality , has increased morbidity and cost , with a majority of expense related to preventable hospitalizations.
Improved methods to evaluate blood use patterns in sub-Saharan Africa may help set realistic national blood collection goals.
Improved outcomes were demonstrated in the Level I center treating a higher proportion of elderly patients.
Improved quality of prognostic studies may identify modifiable peri-operative factors to improve quality of care for vascular surgical patients.
Improved recognition of UI risk among cancer survivors will help clinicians better anticipate and mediate the effect of UI on individuals ' HRQOL.
Improved scientific understanding will in the future hopefully provide the basis for the development of specific and even curative therapies for our patients.
Improved scores were associated with a one-point lower urinary tract symptoms ( LUTS ) score , p < @number@
Improved selective attention and conflict resolution was significantly associated with functional capacity at @number@ months ( r = @number@ P = @number@ ) .
Improved sleep quality accounted for the reduced sleepiness during days off , but reduced stress was a second factor.
Improved stability of blood glucose is a favorable outcome , which enhances the safety of intensive insulin therapy.
Improved TIP over @number@ years was associated with @percent@ decreased risk of having any depressive symptoms at Wave @number@ ( OR @number@ @number@.63-0.89 ) .
Improved tools to distinguish lethal from indolent disease are critical.
Improved tumor progression and animal survival were found at different TMZ doses ( up to @percent@ and @percent@ , respectively ) .
Improved understanding of depression attributes may help to close gaps in care for older men.
Improved understanding of the relationship between functional limitations and co-occurring chronic diseases ( multimorbidity ) is an emerging area of interest.
Improvement.
Improvement after treatment of the face represented a full wrinkle class reduction.
Improvement by masked assessment at day @number@ was @percent@.
Improvement can be seen as early as @number@ month and as long as @number@ months after treatment.
Improvement from baseline was signi - cant in both treatment programs for each skin attribute.
Improvement from sub- or supratherapeutically dosed patients to correctly dosed patients was simulated , assuming that genotyping would prevent under- or overdosing of patients.
Improvement in 10-year AF prediction was assessed by C-statistic , category-based net reclassification improvement , and relative integrated discrimination improvement.
Improvement in cognitive function was not statistically significant.
Improvement in collagen content at two weeks of daily treatments was assessed.
Improvement in depressive and psychotic symptoms from baseline to treatment end was similar in both the Young Old and Older groups.
Improvement in diagnosis , notification quality , a rapidly aging population , and a great demographic dynamism could in part explain this fact.
Improvement in jowling was common but less significant than the improvement of the midface structures.
Improvement in nutritional status was associated with greater improvement in mobility scores.
Improvement in perioral rhytides was evaluated by using the Glogau classification system ( range , @number@ to @number@ ) .
Improvement in surgical outcomes may be achieved through better understanding of radiographic spino-pelvic parameters and their association with deformity.
Improvement in the SUI condition was evaluated by applying the International Consultation on Incontinence Questionnaire - Urinary Incontinence Short Form ( ICIQ-UI SF ) .
Improvement in time spent walking was primarily observed in the group able to perform the Timed Up & Go task at admission.
Improvement of immune functions and stress response systems occurs in elderly after physiological zinc supplementation.
Improvement of prevention strategies and caring for people with dementia should be undertaken.
Improvement of the OXPHOS efficiency was stronger in APP cells than in control cells.
Improvements both in early and long-term follow-up care of cancer survivors seem warranted.
Improvements in acne scars were noted but not graded.
Improvements in blood pressure ( BP ) control and related health outcomes require innovative approaches that reach beyond the clinical environment.
Improvements in chronic care aim to better integrate care through Disease Management Programs , the electronic health card , and voluntary primary care schemes.
Improvements in cognition were identified along with significant CBF correlates of the cognitive gains.
Improvements in continence status can help to enhance overall and health-related quality of life.
Improvements in endothelial function are observed with endurance exercise in older men , but are diminished or absent in older women.
Improvements in executive function reached their peak at @number@ months after surgery.
Improvements in far acuity in younger adults and in near acuity in older adults were also found.
Improvements in functional and immunologic status suggest that ongoing clinical development of cell-based therapy is warranted for frailty.
Improvements in HbA1c ( p = @number@ ) , but not SBP or LDL , mediated the effect of the intervention on cognitive decline.
Improvements in health and longevity in countries such as the UK and USA have radically destabilised notions of ageing and old age.
Improvements in health care have greatly increased life span in the United States.
Improvements in health care have increased human life expectancy in recent decades , and the elderly population is thus increasing in most developed countries.
Improvements in leg spring stiffness and maximum power would be beneficial for both aging and athletic populations.
Improvements in material composition have reduced the risk of material failure.
Improvements in mood and disability are more consistent than changes in cognition , which are little studied after CBTs.
Improvements in OHS were significantly greater in the PRF group at @number@ week , @number@ weeks , and @number@ weeks.
Improvements in psychotropic prescribing were observed ; however , the interventions had limited effects on other outcomes such as wellbeing , falls and dementia severity.
Improvements in skin texture , tone , and smoothness were reported in all patients.
Improvements in stem design , cement technique , and the additional use of locking screws have minimized the risk of aseptic loosening.
Improvements in the quality and implementation of medical care for individuals with cystic fibrosis ( CF ) have resulted in a dramatic improvement in survival.
Improvements in these determinants may contribute to increasing exceptional aging.
Improvements in treatment and survival of sepsis could influence population mortality , and sepsis should receive greater attention in official death statistics in the future.
Improvements of typing methods already in use have to be achieved to facilitate S. maltophilia infection control at any level.
Improvements transferred to performance for an untrained stimulus orientation and were not associated with changes in retinal illuminance.
Improvements were determined by blind evaluation of photographs before , at @number@ weeks , and at @number@ weeks following treatments.
Improvements were greater in team versus net sports ( P < 0·05 ) .
Improvements were made in the collection protocol for Wave @number@ and assays were performed by a different lab.
Improvements were maintained or continued ( eg , mental well-being ) overtime.
Improvements were noted in endothelial function , systolic blood pressure , and markers of oxidative stress and inflammation in several studies.
Improvements with other novel risk markers were limited.
Improvement was quantified as 76-100% by two subjects , 50-75% by three subjects , and 25-49% by nine subjects.
Improvement was seen in Boston Diagnostic Aphasia Examination tests of verbal and non-verbal agility @number@ weeks post-treatment.
Improve visual function by increasing rhodopsin regeneration and ocular health is the earliest reported bioactivities of anthocyanin.
Improving activity may reduce the risk of stroke in this segment of the population.
Improving care in this population will require management of both index conditions as well as comorbid ones.
Improving cognitive skills may help AL residents maintain their functional abilities , enabling them to \ "age in place \ " in AL.
Improving CVH may be instrumental in the prevention of poor physical function in older adults.
Improving immunization rates across multiple LTC facilities remains an elusive challenge.
Improving knowledge and understanding about the pathogenesis of depression will have important public health implications.
Improving mobility performance in older adults with visual impairment may minimize the perception of mobility disability.
Improving our understanding of the cellular basis of obesity could set the stage for the development of new therapeutic strategies.
Improving paramedic education as it pertains to geriatrics is a critical next step.
Improving quality of life , assuring patient safety and avoiding the adverse effects of antidiabetic treatment should be prioritized.
Improving rates of diagnosis has become a key part of current dementia guidelines.
Improving regulations will likely improve not only the well-being of foreign home attendants but also the care they provide.
Improving reporting and estimation of whole-grain intake will enable easier comparison between different studies and lead to stronger meta-analyses in the future.
Improving the safety of walking environments in areas where older adults shop and do other errands of necessity is an important component of fall prevention.
Improving the taste of low-sodium food may help to promote reduction in dietary sodium intake.
Improving working conditions amongst the lowest social groups may help to reduce social inequalities in mortality.
Imprudent administration of antioxidants may therefore have a negative impact on the organism.
Impulsivity , assessed in a subgroup of subjects , was also associated with SI ( p = @number@ ) .
Impulsivity was assessed with the Social Problem Solving Inventory Impulsivity / Carelessness Style subscale and Barratt Impulsiveness Scale.
Impulsivity was measured with the Barratt Impulsiveness Scale Version @number@ ( BIS-11 ) .
Imputation methods using the probabilistic model are common , but they cannot impute individual data and require special software.
Imputed estimates of frailty prevalence were @percent@ to @percent@ higher than those derived from the observed data.
IMTG accumulate in form of lipid droplets decorated by proteins such as Perilipins ( Plins ) .
IMT in plaque-free site and atherosclerotic plaques in the extracranial carotid arteries were determined using a standardized protocol.
IMT > @number@ mm was found in @percent@ of cases and arterial calcifications at US in @percent@.
IMT of the common carotid artery was determined using ultrasonography.
In 10%-28% of cases , PPOI causes primary and in 4%-18% secondary amenorrhea.
In 12-month-old offspring DEX exposure caused an increase in basal blood pressure of ~3 mmHg.
In 13-year-old girls , all PT were erupted regardless of their nutritional status indicating a catch-up.
In 15 / 26 ( @percent@ ) , incident amyloid positivity occurred prior to abnormalities in FDG-PET and hippocampal volume.
In 18-month-old AβPP23 mice , plaque formation and gliosis in cortex and hippocampus were accompanied by decreased GLT-1 expression.
In 1970s , dementia was delineated from normal aging , and the present concept of dementia was established.
In 1985-1994 , @number@ women aged 55-years took part in the baseline investigation.
In 2001-2002 the same subjects were invited for a follow-up examination ( SAPALDIA @number@ ) .
In 2004-2011 , @number@ AMI patients were registered.
In 2005-2008 , all participants underwent neuropsychological examination.
In 2006-2007 two groups simultaneously reported the existence of a special pathway for maintaining epithelial polarity in the face of environmental stressors.
In 2007-2011 , the second assessment was done of @number@ study subjects aged ≥65 years who were still alive.
In 2008 / 2009 , respondents were asked about social functioning and participation.
In 2009-2010 , @number@ patients diagnosed with the coronary heart disease , but without the expressed metabolic violations , decompensated conditions and diseases were surveyed.
In 2010 / 11 , a random subgroup men was clinically investigated and survivors with healthy and nonhealthy aging were compared.
In 2010 / 11 , @percent@ of the municipalities had such services , which filled @percent@ of the beds in nursing homes.
In 2010-2011 , data were collected through interviews , clinical examinations , and laboratory tests.
In ~5-10% of the patients the disease segregates with an autosomal dominant ( AD ) pattern.
In 5- and 7-year-olds there were no differences in the repeatability of stability indices between the left and right foot.
In 66- to 76-year-old participants , the absolute risks of mortality and disability were higher , but risk gradients across wealth quintiles were similar.
In 8-month-old animals , we could not observe plaque formation or gliosis.
Inability to repair the damage or exposure to prolonged stress may contribute to aging.
In a bivariate analysis , no significant differences were observed.
In a blinded study of @number@ samples we show very high sensitivity and specificity are achievable using either Ion Torrent or MiSeq sequencing platforms.
In about two thirds of elderly subjects , the age-related decline of renal function was associated with coexisting cardiovascular diseases and other risk factors.
In abroad , several routes are available for the administration of testosterone , such as injection , patch , oral administration , etc.
In absence of a low FMR1 allele , OR of clinical pregnancy ( vs. chemical or no pregnancy ) was @number@ in middle-aged infertility patients.
In absence of family history , they mimicked sporadic Creutzfeldt-Jakob disease ( CJD ) .
In absolute terms , readers were sensitive to predictability , regardless of age or literacy , in both early and later measures.
In accordance , a decrease of the functional connectivity inside the default mode network was observed in the decliners.
In accordance , complement anaphylotoxin C5a led to a significant down-regulation of Klotho in TEC in vitro that was NF-kB mediated.
In accordance with findings in postmortem PD brains , small oligomeric species occurred and the autophagic flux was impaired in our model.
In accordance with most gerontologists ' assertions it starts in the fourth decade of life and leads to death.
In accordance with previous findings , we observed association preferentially in females ( p = @number@ ) .
In accordance with this model , microarray expression profiling demonstrated that PAPD5 knockdown results in a down-regulation of miR-21 target mRNAs.
In accordance with this observation , IL-17A was able to markedly increase TNFα-induced neutrophil adherence to HDMEC monolayers in an in vitro adhesion assay.
In accord with previous studies , our results showed that the DTI parameters were more related to IIV than to mean performance.
In accord with prior work , we show that several chemotherapeutic drugs induce senescence of primary murine and human cells.
Inaccuracy and bias were measured to gauge the magnitude and direction of difference between estimated ages and chronological ages among the five observers.
Inaccuracy showed that absolute errors of estimated ages against known ages are substantial.
Inaccuracy was the lowest for individuals younger than @number@ and the greatest for individuals over @number@
In a cell-free system , MHY336 exhibited a potent activity on scavenging of reactive oxygen species against 3-morpholinosydnonimine hydrochloride ( SIN-1 ) -induced oxidative stress.
In ACHF ; left ventricular ejection fraction ( LVEF ) percent was reduced.
In achieving this goal the choice of an appropriate study models is fundamental.
In a clinical study that evaluated the efficacy of sitafloxacin , @number@ patients with CAP had been previously enrolled.
In a clustered RCT , the effects of the different intervention conditions were compared to each other and to a control group.
In a concentration-dependent manner , it thereby interferes not only with endothelium-dependent , NO-mediated vasodilation , but also with other biological functions exerted by NO.
In a control group , a standard formula without prebiotics was given.
In a control study , we removed the competing perceptual information to decrease perceptual load.
In a Cox multivariate analysis model , none of the relevant characteristics was shown to be a critical prognostic feature for OS.
In a cross-sectional analysis , IOP also showed a negative correlation in all age groups ( respectively , P < 0.001 ) .
In a cross-sectional analysis on CSHA-1 subjects , any association between stroke history and cognitive function was studied.
In a cross-sectional study of @number@ Puerto Ricans aged 47-79 y , we modified the AHA-DLS to test associations with bone health.
In a cross-sectional study of older females , the present study examines whether a history of rape is associated with current psychological and health problems.
In a cross-sectional study , persons with SCI ( N = @number@ time since injury of ≥10 years ) were tested.
In a cross-sectional study , we found that brachial shear rate patterns and brachial artery intima-media thickness ( IMT ) correlated with age.
In activated cells , NR4A receptors are rapidly and potently induced , suggesting that these receptors may act as important transcriptional mediators of inflammatory signals.
Inactivated virus particles and recombinant gp41 have been reported to inhibit lymphocyte proliferation , as well as to alter cytokine release and gene expression.
Inactivation of insulin / insulin-like signaling increases lifespan in nematodes , fruit flies , and mice.
Inactivation of MOAG-4 suppresses the formation of compact polyglutamine aggregation intermediates that are required for aggregate formation.
Inactivation of Poln in mouse embryonic fibroblasts did not alter cellular sensitivity to mitomycin C , cisplatin , or aldehydes.
Inactivation of the Hippo pathway or activation of its downstream effector , the Yes-associated protein transcription coactivator , improves cardiac regeneration.
Inactivation of the innate immune system observed in COPD smokers is remarkably similar to the immunosenescence phenotype associated with aging.
Inactivation of the proteasome appeared to be a likely contributor to the accumulation of such damaged proteins.
Inactivation of the RB tumor suppressor and activation of the MYC family of oncogenes are frequent events in a large spectrum of human cancers.
Inactivation of the retinoblastoma protein ( Rb ) has a key role in tumorigenesis.
Inactivation of the retinoblastoma protein ( RB ) has a major role in the development of human malignancies.
In active women , TP ( g / kg / BW ) was positively associated with LS BMD and FN BMC changes.
Inactivity , by contrast , has serious negative effects on health across the lifespan.
Inactivity has contributed considerably to the pervasiveness of lifestyle diseases.
In acute rejection after renal transplant , glomerulitis is characterized by mononuclear cells in glomerular capillaries and endothelial cell enlargement.
In AD , both CLU and CR1 genes were implicated in the late-onset form of the disease.
In AD brains , BACE1 is abnormally accumulated in endocytic compartments , where the acidic pH is optimal for its activity.
In AD , but not DLB , patients , NSD was associated with more advanced disease.
In AD cases , on average , 49%-64% of microglia had discontinuous and / or punctate Iba1 labeled processes instead of continuous Iba1 distribution.
In addition , aberrant epigenetic marks have been found in several hematological malignancies , consistent with clinical findings that mutations targeting epigenetic regulators promote leukemogenesis.
In addition , a brief assessment that nurses could use to assess for impaired sleep and nonpharmacologic interventions to improve sleep are discussed.
In addition , accelerated expression profiles associated with AD and FTLD suggest some common mechanisms underlying the risk of developing these diseases.
In addition , a close relative of each participant completed the Initiative Interest Scale , a new questionnaire assessing apathetic manifestations in aging.
In addition , a combination of Allium atroviolaceum and doxorubicin led to a significant synergistic effect.
In addition , a comparison with the natural decrease in exercise capacity in healthy subjects ( in both children and adults ) is lacking.
In addition , actions of adiponectin at the testicular level have been shown to promote spermatogenesis and sperm maturation.
In addition , activation of NF-κB up-regulates the expression of matrix metalloprotease-1 ( MMP-1 ) and consequently collagen in dermis is degraded.
In addition , acute hippocampal slices treated with GlcNAc / UDP-GlcNAc showed a clear reduction of long-term potentiation of excitatory synapses.
In addition , adapting the supermatrix of ANP to the calculation of the house of quality ( HoQ ) will reduce subjective judgments.
In addition , adducts of LPO products to proteins was reported during aging and age-related diseases.
In addition , adiponectin is decreased in the patients with obesity and T2DM.
In addition , a discussion was provided on the practice , policy and research implications for promoting the development of protective factors and resilient ageing.
In addition , administration of ursolic acid attenuated the hepatic malondialdehyde levels and reduced the plasma aspartate aminotransferase and alanine aminotransferase levels after trauma-hemorrhagic shock.
In addition , adoptive transfer of STAT3-deficient macrophages into eyes of old mice significantly reduces the amount of CNV.
In addition , a double-labeling experiment with TUNEL staining and immunofluorescence revealed the co-localization of nuclear AIF-positive and TUNEL-labeled cells.
In addition , a dramatic increase of secretory cells was observed in high-risk and PSC patients.
In addition , after a longer period of time , treatment may confer risk , especially in older women.
In addition , after @number@ years of treatment , it showed a reduction in vertebral and non-vertebral fracture risk.
In addition , aged WM becomes more susceptible to neurological disorders , such as stroke , traumatic brain injury ( TBI ) , and neurodegeneration.
In addition , a gene×gene interaction effect on Conscientiousness was revealed : the TPH2 genotype effect was evident only in the 5-HTTLPR S-allele carriers.
In addition , agents that scavenge ROS or reverse the Warburg effect prevent the transformation and malignant phenotype observed in cells lacking Sirt3.
In addition , age-related decreases in the connection strength of the edges between peripheral nodes were observed in aMCI patients.
In addition , aging and aging-related co-morbidities affect the paracrine activity of stem cells and the efficiency of their transplantation.
In addition , aging induces oxidative stress in lymphatic vessels and facilitates the spread of pathogens from these vessels into perilymphatic tissues.
In addition , aging is accompanied by a progressive decline in stem cell function , resulting in less effective tissue homeostasis and repair.
In addition , aging was associated with decreased proliferative responses to mitogens in both sexes.
In addition , agreement metrics were better than those returned using existing kinematically derived event detection algorithms developed for overground gait.
In addition , a higher absolute but similar relative IB was observed in young vs. older cyclists , despite a higher VO₂max in the former.
In addition , a higher adherence to the MeDiet pattern strengthens the prevention of telomere shortening among Ala carriers.
In addition , a higher degree of clinical anticipation was associated with maternal transmission than with paternal transmission.
In addition , a high level of p190 mRNA expression was observed in majority of surgically obtained tissue from lung adenocarcinoma patients.
In additional analyses restricting the follow-up to @number@ months , plasma total tau did not predict decline among CN participants.
In addition , alcohol exposure during adolescence facilitated spatial memory impairments to acute ethanol challenges later in life.
In addition , a linear regression model was fitted to all three DTI parameters in each part of the fornix.
In addition , alizarin red-S , sudan III , toluidine blue , and cresyl violet staining were performed to evaluate the multi-lineage differentiation of hADSCs.
In addition , all patients completed Symptom Check List-90 ( SCL-90 ) .
In addition , all the skin aging parameters on the knee were significantly correlated with Crow's feet ( P < @number@ ) .
In addition , almost one out of five treated men had baseline serum testosterone values above the threshold defined as normal by the Endocrine Society.
In addition , ALP activity and mineralization was found to be increased by curcumin treatment.
In addition , also decreases of temperature or increasing the ATP concentration result in reduced inhibition.
In addition , alterations of immune cells in corneas suggest an inflammatory component in diabetic complications.
In addition , altered expression of A-type lamins is emerging as a contributing factor to tumorigenesis.
In addition , although women received more years of personal assistance than men , women experienced more unmet care assistance needs.
In addition , a Mediterranean dietary intervention may mitigate potential deleterious effects of elevated plasma ceramide concentrations on CVD.
In addition , a method for counting glomeruli in developing kidneys is described.
In addition , a myriad of factors make determining their intake and status and investigating their discrete contributions to health particularly challenging.
In addition an age-by-task interaction was observed within a distributed network , including DLPFC and ACC , with greater activity during interference in the old.
In addition , an age-related reduction in VZV-RCF was observed in the depressed patients , but not in the controls.
In addition , analysis of variance or unpaired Student t tests are frequently used to compare mean performance times across age groups.
In addition , and where feasible , a multidisciplinary team approach has demonstrated the most durable results.
In addition , an equivalent number of primary rhytidectomy patients were selected randomly.
In addition , an extended cylinder of hydration is thought to be responsible for collagen fiber assembly.
In addition , an interaction between the presence of atherosclerotic disease and ADMA on the odds of frailty ( p = 0.045 ) was detected.
In addition , an inverse association of joint score with BMD and failure load suggests the negative role of hemophilic arthropathy in bone density loss.
In addition , an inverse relationship between miR-125b and p53 expression was seen in age-related cataract tissue.
In addition , an in vitro kinase assay showed that DYRK1B phosphorylated NKX3.1 at serine @number@ a residue critical for NKX3.1 steady-state turnover.
In addition , a non-demented ( ND ) group ( average age @number@ years ) with no amyloid plaques was included for comparison.
In addition , a normal ion intensity buffer can be used without dilution for the proposed method.
In addition , a novel miRNA was predicted and submitted to the miRBase database as bta-mir-10020.
In addition , an overview is provided of major discoveries made in mitochondrial biology in each of these four model systems.
In addition , antiglycation activity of SMFE was confirmed in a human skin explants model.
In addition , anti-miR-574-3p reversed tamoxifen-mediated suppression of MCF-7 cell growth.
In addition , antioxidant enzyme activities of superoxide dismutase ( SOD ) , glutathione peroxidase ( GSH-Px ) and catalase ( CAT ) were analysed.
In addition , a pilot study was conducted to investigate motivations and expectations of participants in immunotherapy RCTs.
In addition , APOE ε4 carriers have lower CSF Aβ ( @number@ ) levels than non-carriers.
In addition , a positive family history for psychiatric and / or neurodegenerative diseases was present.
In addition , a randomized clinical trial of B vitamins demonstrated a beneficial effect for AMD with the vitamin B complex.
In addition , areas of future research are addressed , including concerns related to the dissemination of exercise interventions on a widespread scale.
In addition , ARE suppressed the in vitro tumor growth through mitochondria-mediated apoptosis.
In addition a RRI > 0.74 can predict the onset of AKI in septic patients.
In addition , ART stimulated the aggregation of LC3 , which is considered to be a marker of autophagosome formation.
In addition , as age increased , physical symptoms intensified and psychosocial symptoms tapered ( physical unstd.
In addition , Asians had the highest survival of all race groups ( 3-year survival : @percent@ , p < @number@ ) .
In addition , a significant decrease of glutathione transferase activity in selected areas of brain and in ventricular cerebrospinal fluid was found.
In addition , a significant increase in collagen density and skin firmness was observed after @number@ weeks.
In addition , a significant number of neoplastic lesions are likely being missed in PLWHA who have not been screened for CRC.
In addition , a significant reduction of cortical bone thickness and histopathological alterations in the testicles were found in Hz mice when compared to controls.
In addition , associations of @number@ loci are directionally consistent with previous reports.
In addition , a strong correlation was found between the monocyte / macrophage content in fat and age only in older women.
In addition , a substantial percentage of people ( about @percent@ ) exhibited increased stem cell counts after the MBT.
In addition , a synthesis related to other lines of supporting evidence for the role of adipose hormones in dementia will be provided.
In addition , a T2 correction was performed to obtain the PDFF and the T2 value of water ( T2w ) was calculated.
In addition , autophagic activity appears to be reduced with aging , and the final stages of autophagy in neurodegenerative process appear to be impaired.
In addition , a weighted genetic risk score was associated with linear rate of change in episodic memory and information processing speed.
In addition , Aβ-induced production of proinflammatory chemokines / cytokines was decreased in mouse organotypic hippocampal slice cultures expressing human apoA-I.
In addition , Aβ positive cerebral amyloid angiopathy ( CAA ) , neuritic plaques and various ubiquitin positive structures were also observed.
In addition , behavior was best predicted by the 70-dB signal / 5-dB SNR CAEP condition.
In addition , beta-amyloid ( Aβ ) expression and its correlation with SOM cells have been quantified under confocal microscopy.
In addition , beta blocker subgroup , site , and stage-specific analyses were performed.
In addition , betaine inhibited insulin-induced PI3K / AKT and FOXO1 activation.
In addition , bicarbonate was not significantly associated with change in gait speed.
In addition biomarkers have emerged which will allow the identification of patients with a high risk of cardiovascular hepatic and gastrointestinal side effects.
In addition , biopsies were obtained from @number@ control subjects.
In addition , Bland and Altman analysis tested the bias.
In addition , blood glucose levels decreased in an age-dependent fashion.
In addition , blood samples were collected to determine biochemical and oxidative stress.
In addition , BLT produced continuing improvement in mood and an attenuation of cortisol hyperexcretion after discontinuation of treatment.
In addition , BN prediction generated stochastic variability in the FM% expressed in terms of BMI.
In addition , body composition was assessed by bioelectrical impedance analysis ( BIA ) .
In addition , BoNTA-naïve participants demonstrate greater improvements in QOL and self-esteem than participants previously exposed to BoNTA.
In addition , both age and BMI modified the chocolate-DM relation ( P < @number@ each ) .
In addition , both DHJST and L. chuanxiong delayed the hMSCs aging process by decreasing cell senescence.
In addition , both groups showed increased connectivity with the left postcentral gyrus.
In addition , both prevalence and incidence figures of adhesive capsulitis are increasing.
In addition , boys with high zFMI had also a lower CRAE to CRVE ratio ( β = -0.26 , P = 0.03 ) .
In addition , brain aging mechanisms are especially critical for disease vulnerability , given the aging-related prevalence of pathologies that include neurodegenerative diseases.
In addition , BSN involvement was positively associated with independence in basic and advanced ADL.
In addition , by phosphorylating and inactivating PP1 , Cdk5 promotes tau phosphorylation at Ser ( @number@ ) indirectly.
In addition , by the Bland-Altman plot , HR confirmed good agreement between the methods with biases between @number@ and @number@ beats per minute.
In addition , calf muscle density increased by @percent@ ( P < @number@ ) .
In addition , CaN and NF-κB inhibition attenuated isoflurane-induced neuroinflammation and subsequent cognitive impairment.
In addition , cancer itself may expose old patients to infections , including opportunistic infections , i.e. Pseudomonas aeruginosa , Aspergillus fumigatus and Cytomegalovirus infection.
In addition , care is needed when interpreting our results , as we do not have semen measures on our sample of fertile men.
In addition , carrier diagnosis and genetic counseling for the proband family are of great significance.
In addition , CD45RA + CD27⁻ CD4 + T cells have cytotoxic potential as they express high levels of granzyme B and perforin.
In addition , CD56 + monocytes spontaneously produced more reactive oxygen intermediates than CD56- monocytes.
In addition , CDR1 expression has been detected in neuroblastoma , renal carcinoma cell lines , and other cancer cell lines.
In addition , cell culture experiments revealed that they had good biocompatibility compared to the scaffolds without KDIOP.
In addition , cells expressing low levels of WRN responded favorably to cisplatin , whereas cells expressing high levels responded poorly to cisplatin.
In addition , cells showed a marked increase in cell size in both cell lines and a more adhesive cell profile for MEG-01.
In addition , cellular proliferation and cytokine secretion properties were determined.
In addition cellular senescence drastically increased in older cells compared with Young cells both in presence and in the absence of oxidative stress.
In addition , central corneal thickness was measured by time-domain optical coherence tomography.
In addition , certain cutaneous and systemic diseases that are associated with pruritus are more prevalent in the elderly.
In addition , changes in marital and employment status were significantly associated with changes in functional health in men , but not in women.
In addition , chemical and genetic inhibitions of Chk1 elongated lifespan and recovered eye degeneration.
In addition , chlorogenic acid had a significantly lower effect on mouse bleeding time when compared to the same dose of aspirin.
In addition , chondrogenesis and proteoglycan synthesis may have critical roles in the pathogenesis of the ligamentum flavum hypertrophy.
In addition , chronic wounds associated with the patient's conditions may also increase his / her falls risk.
In addition , circulating AMH strongly correlates with antral follicle count ( AFC ) , visualized by ultrasound in the follicular phase of the cycle.
In addition , classical staining techniques often require lengthy protocols and do not offer objective quantification.
In addition , clinical and pharmacological studies have helped to increase the comprehension of the adrenergic signaling pathway.
In addition , clinical practice guidelines recommend use of oral nonsteroidal anti-inflammatory drugs with extreme caution and for defined , limited periods.
In addition clock gene polymorphisms and aging may have also chronodisruptive effects.
In addition , CMA contributes to cellular quality control through the removal of damaged or malfunctioning proteins.
In addition , co-administration of recombinant sFRP1 could abrogate the accelerated CDC proliferation induced by Wnt3A.
In addition , coexpression of calcineurin A , a target of RCAN1 , could rescue RCAN1-suppressed vascular branching.
In addition , coffee intake is associated with risks of heart failure , stroke , diabetes mellitus and some cancers in an inverse dose-dependent fashion.
In addition , cognitive failures directly and indirectly predict suicide ideation in this sample of older adults with BD.
In addition , cognitive performance did not differ significantly between groups and was not significantly associated with SH in this cohort.
In addition , cognitive reserve was investigated by testing whether education affected the onset or rate of decline across these domains.
In addition , cognitive task effects on step width variability differed between two age groups.
In addition , comet assay protocols in use in different laboratories vary significantly.
In addition , coming from the Indian or Asian African population group was associated with short sleep.
In addition. common long-term cancer-related symptoms and late effects of cancer treatments provide challenges to nurses and other health professionals caring for older cancer survivors.
In addition , community contexts that are supportive of pedestrian travel significantly increase this mode of mobility.
In addition , community-level recreational and social opportunities to combat isolation are identified.
In addition , comorbidity and polypharmacy are highly prevalent in the elderly.
In addition , comparisons of USE-PAP responses with direct observations of PAP-related tasks and objectively measured PAP adherence are needed to fully evaluate the questionnaire.
In addition , computerized measures of cognitive control assessing working memory , inhibitory control , and set-shifting were also administered.
In addition , conditional activation of neuronal autophagy in young animals is protective while late activation is deleterious for survival.
In addition , conventional surgical management appears to be limited in its ability to reconstruct tracheal defects.
In addition , conversion of L- to D-aspartyl residues is accelerated by ultraviolet ( UV ) irradiation.
In addition , cord blood pDCs efficiently cross-presented antigen to CD8 ( + ) T cells.
In addition , cordycepin inhibited IL-1β-induced COX-2 and iNOS expression at the transcript level as well as blocked NO production.
In addition , cost-effectiveness will be determined.
In addition , co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo.
In addition , CR enhanced adhesion of JAr cells onto Ishikawa cells by inducing the expression of LIF-dependent integrins αVβ3 and αVβ5.
In addition , cryptotanshinone significantly increases the lifespan of SOD2-deleted mutants.
In addition , CSRT reduces the normal age-related decline of somatotropic hormones in middle-age men.
In addition , CST does not include any formal carer training.
In addition , CT scans of the head from @number@ young adults ( 20-40 years old ) were retrieved from a medical records database.
In addition , culture proliferation was inhibited and morphological changes characteristic of differentiation and cell aging developed.
In addition , current osteoporosis therapies also appear to be safe in the elderly.
In addition , cutoff scores were recommended based on sensitivity and specificity of scores.
In addition , damage levels are well below expected thresholds for platelet activation.
In addition , d-amino acid substitutions in crystallin-mimic peptides showed altered structural formation and function.
In addition , DAPI-defined SAHF were detected on paraffin sections of Ras-transformed cultured fibroblasts , but not human lesions at various stages of tumorigenesis.
In addition data about the process of doing appreciative action research helped to realise its application and relevance in the health care setting.
In addition , data addressing the potential value of amyloid PET imaging in the clinical setting are highlighted.
In addition , data regarding the role of testosterone replacement therapy ( TRT ) for glycometabolic control and CV risk remains contradictory.
In addition , @date@ is capable of enhancing promoter activity of a lactase promoter-reporter construct harboring the 13915 G SNP sequence in cell culture.
In addition , DDE diminished both basal and TNFα-induced lipolysis.
In addition , DDIs are often difficult to treat or are life-threatening.
In addition , decades of low income and labour market exclusion prohibit many Canadian immigrants from building adequate private pension savings throughout their working life.
In addition , declined osteoblastogenesis by Nampt deficiency or addition of FK866 was related to lower intracellular NAD concentration and decreased Sirt1 activity.
In addition , decreased OFC volume was induced by failing to extinct conditioned fear soon after the traumatic event.
In addition , decrease in LF / HF was an independent risk factor for mortality.
In addition , deletion of p75NTR attenuated microgliosis but increased the microhemorrhage profiles in the brain.
In addition , demographic parameters such as age , sex , chronic diseases , permanent medications , level of dependency and cognitive state were recorded.
In addition , depending on region of interest , both increases and decreases in structure and function were associated with behavioural performance.
In addition , derivatives of resveratrol , including glucosylated molecules as polydatin have been linked to similar beneficial effects.
In addition , derivatives of resveratrol , including glucosylated molecules , have been linked to similar beneficial effects.
In addition , DEX exposed mice had a widened pulse pressure compared to SAL.
In addition , discrete values of lower limbs ' peak net moment and ROM were also evaluated.
In addition , disk degeneration was quantitatively evaluated by Pfirrmann score on T2-weighted magnetic resonance images in patients with retrolisthesis.
In addition , DNA damage induces Rb dephosphorylation in a PP2A-dependent manner , and this process is inhibited by Pin1.
In addition , doxorubicin treatment induced the expression of retinoblastoma protein in a p53-dependent manner.
In addition , dual-task costs ( DTCs ) were calculated.
In addition , during the return movement phase , only older participants showed a context-dependent increase in COP path deviations after grasping compared to pointing.
In addition , dysregulation of cerebral insulin sensitivities and signaling activities have been implicated in AD.
In addition , dystrophin-negative and dystrophin-positive isolated cardiomyocytes show augmented calcium response to mechanical stress , similar to mdx cells.
In addition , efferent innervations undergo plasticity during pathological conditions such as noise-trauma or aging.
In addition elderly participants showed increased latencies for P1 and N1 components.
In addition , elderly people appeared unable to resolve their inflammatory response to severe injury effectively.
In addition , emerging evidence links autophagy to a wide array of vascular processes ranging from angiogenesis to calcification of the vessel wall.
In addition , emotional dimensions of negative and positive pictures were divided into high-arousal and low-arousal.
In addition , enactive encoding led to a better memory performance than verbal encoding in both age groups.
In addition , endurance athletes must include adequate vitamins and minerals in their diets to maintain healthy immune function.
In addition , enrichment of LON and AFG3L2 is evident in StAR-expressing ovarian cells examined by confocal microscopy.
In addition , ensuring vision problems are corrected where possible may lead to improvements in well-being.
In addition , enzalutamide significantly delayed the need for chemotherapy and the decline in health-related quality of life versus placebo.
In addition , ER stress inducers can augment ATF4 expression.
In addition , estrogens may also influence cognitive function indirectly , via the modulation of other systems that impact cognition.
In addition , ethanol and 17β-estradiol separately and pre- and post-ethanol 17β-estradiol treatment increased iNOS expression.
In addition , Eucalyptus globulus inhibited activation of the AP-1 transcription factor , an inducer of MMPs.
In addition , Euro Qual five Dimensions assessments were performed and patients were screened for UTI symptoms.
In addition , exercise is effective for the improvement of bone mineral density in the elderly.
In addition , exercise training induces peripheral vascular adaptations within the cutaneous microvasculature indicative of enhanced endothelium-dependent vasomotor function.
In addition , exploration of the theoretical and conceptual frameworks used to establish national and organizational initiatives is reviewed.
In addition , expression of proteins involved in cytoskeletal structure and EIF2 signaling was reduced.
In addition , factors associated with poor response to treatment at @number@ months , despite normalization of objective measures , were examined.
In addition , family members who care for patients with medical diagnoses often suffer from depression.
In addition , fat mass displayed a significant reduction ( p < @number@ ) following the training period only for the obese group.
In addition , favorable SRH is indicated not only by the absence of loneliness at both measurement points , but also by decreased loneliness.
In addition , fecal incontinence is associated with shame , social isolation and reduced quality of life.
In addition , female gender is the effect modifier rather than the risk factor.
In addition , females and young adults with more severe drug problems may be more amenable to behavior change.
In addition , female sex was a risk factor for both the utilization of home-help services and nursing home placement.
In addition , females produced more conditioned eyeblink responses than males among both children and adults.
In addition , FGF21 acts as a stress hormone induced by endoplasmic reticulum stress and dysfunctions of mitochondria and autophagy in several tissues.
In addition , FGF21 also acts directly through its coreceptor β-klotho in the brain to alter light-dark cycle activity.
In addition , fixed effects meta-analyses for these interactions were performed.
In addition , four cross-cutting themes were identified : biomarkers , bioinformatics , comparative effectiveness research , and dissemination and implementation science.
In addition , fracture incidence over @number@ years was assessed.
In addition FS can be used as a research tool to improve outcomes for elderly burn injured patients.
In addition , full length WRN with the mutation expressed in 293T cells was not phosphorylated in response to DSBs produced by bleomycin.
In addition , functional balance was evaluated by means of the Balance Evaluation - Systems Test ( BESTest ) .
In addition , funding organizations nowadays stress the importance of participation of older adults in research studies and the usability of research findings to society.
In addition , future investigation about the detailed molecular mechanisms how statins affect calcification process in vascular cells is necessary.
In addition , Galectin @number@ binding to receptor kinases such as CD45 and the T cell receptor is critical in the regulation of their function.
In addition , GAL in the hypothalamus stimulates the opioid , enkephalin , throughout the brain , which also promotes overconsumption.
In addition , gender-specific models suggested several socio-economic and health factors had significantly different effects by gender in both countries.
In addition , gender-specific models suggested several socio-economic and health factors had significantly different effects by gender in both countries.
In addition , genetics and epigenetics also play large roles in accelerating and / or delaying the onset of aging and aging-related diseases.
In addition , genome-wide association studies indicate that α-synuclein and Tau protein synergistically increase disease susceptibility in the human population.
In addition , GHK possesses a plethora of other regenerative and protective actions including antioxidant , anti-inflammatory , and wound healing properties.
In addition , ghrelin and GHSR co-localize in the same taste cells , suggesting that ghrelin works in an autocrine manner in taste cells.
In addition , ghrelin has metabolic , cardiovascular , and anti-aging effects.
In addition , GH secretagogues ( GHS ) also have neuroprotective and cell regenerative effects per se in the brain.
In addition , ginsenoside-Rg5 induced significant concentration-dependent increases in the level of DNA damage compared with the negative control.
In addition , global and regional trends in blood pressure levels and management of hypertension are reviewed.
In addition , glucuronidated androgen metabolites were associated with less subcutaneous fat ( r = @number@ to @number@ P < @number@ ) .
In addition , good health was common among those who never felt lonely.
In addition , gp41 expressed on target cells inhibited the antigen-specific response of murine CD8 + T cells by drastically impairing their IFNγ production.
In addition , GPx1 mRNA was present in lower levels in MR liver than in mouse liver.
In addition , greater concentricity was associated with decreased global longitudinal strain and greater torsion in multivariable models ( all P < 0.001 ) .
In addition , greater involvement of the afferent terminals may occur , particularly the calyx units contacting type I vestibular HCs.
In addition , H2O2 caused the elevation of ( SA-β-gal ) activity and formation of senescence-associated heterochromatin foci ( SAHF ) .
In addition , habitual attention was strongly viewer-centered in both young and older adults.
In addition , hair growth was compared between the VC ( - ) and VC ( + ) groups after shaving.
In addition , having anxiety / depression was a predictor of poorer COPM-P outcomes.
In addition , having hypertension significantly increased the risk of ADL disability in obese individuals and IADL disability in underweight individuals.
In addition , healthy elderly subjects presented a higher plasma total antioxidant capacity.
In addition , heat-exposed Nrf2-knockdown cells showed significantly increased levels of collagenase protein and decreased levels of procollagen.
In addition , hepatic resections for hepatocellular carcinoma or colorectal liver metastases have been reported as safe in the elderly as in the younger population.
In addition , HIF-2α suppresses chondrocyte autophagy , herein promoting chondrocyte apoptosis.
In addition , higher functional connectivity correlated with greater structural damage to network-specific white matter tracts.
In addition , high risk grouping was classified if subjects exhibited @number@ or more biomarkers in the abnormal laboratory range.
In addition , hippocampal structural connectivity maps expressing the probability of connectivity between the hippocampus and cortex were generated using a pipeline based on FSL-probtrackX.
In addition , HIV-infected children may undergo accelerated immune senescence that favors cancer development.
In addition , HS-1793 suppressed Akt and the phosphatidylinositol-3 kinase / Akt inhibitor LY294002 was found to enhance its induction of apoptosis.
In addition , hSGSCs were differentiated into amylase-expressing cells by using a two-step differentiation method.
In addition , HUVECs secrete bFGF in a density-dependent manner.
In addition , Hu-Yi-Neng inhibited H2O2-induced phosphorylation of Akt kinase but further increased the phosphorylation of Erk @date@ .
In addition , hydrogen has no cytotoxic effects to cells so that it provides a near ideal therapy to eliminate toxic free radicals.
In addition , hydroperoxides of polyunsaturated fatty acids formation leads to necrosis and apoptosis.
In addition , hypertension predisposes to atherosclerosis and cardiac diseases ( notably atrial fibrillation ) , thereby promoting cerebral embolism.
In addition , IGF-1 inhibited the translocation of Bax to the mitochondria induced by Aβ.
In addition , Ig isotypes in tonsils preferentially switch from IgM to IgA as individuals age.
In addition , immunocytochemistry staining and flow cytometric analysis were performed to investigate the cell-surface markers.
In addition , impaired long-term potentiation has been demonstrated in OXYS rats by the age of @number@ months.
In addition , improved lipid profiles were observed , with significant decrease in total- and LDL-cholesterol in the treatment group.
In addition , improvement in erectile function is associated with self-reported absence of hypogonadism.
In addition , improvements in clinical and virological measures suggestive of the clinical usefulness were also observed.
In addition , IMT was associated with sleeping hours and hours of watching television ( TV ) by using stepwise regression analysis.
In addition , inadequate muscle fiber vascularization may be a crucial factor underlying impaired regulation of satellite cells in older adults.
In addition , in both groups the occipital , parietal and temporal nodes appear to have the strongest influence on information flow within the network.
In addition , in cognitively intact patients there was a moderate ( about @number@ ) but significant correlation between NOPPAIN ratings and pain self-reports.
In addition , incorporating a wide variety of students ' values and beliefs , designing instructional strategies and including varied assessments adds to the difficulty.
In addition , independent of age , the neuromuscular control of goal-directed movements is different for the upper and lower limbs.
In addition , individual differences in future self-views were reinforced by life events that were consistent with these self-views.
In addition , individuals , specifically , with CDR @number@ have multiple regions with lower volumes than individuals with a CDR @number@
In addition , in elderly patients , comorbidities and drugs therapies may also affect fracture healing.
In addition , in elderly subjects , the pharmacokinetics and pharmacodynamics of antiplatelet and anticoagulant agents often have a quite peculiar connotation.
In addition , infections were required to be of sufficient severity to require inpatient hospitalization and treatment with parenteral antibiotics for at least @number@ h.
In addition , inflammation was associated with increases in neopterin and nitrite levels and in phenylalanine concentrations at the expense of tyrosine.
In addition , information regarding fall risk assessment , dose-response-relations , detraining effects , and supervision of training will be provided.
In addition , information regarding the point of rupture is also very limited.
In addition , in insulin-treated cells , MHY908 prevented the FoxO1 inactivation and increased the expression of MnSOD and catalase by inactivating IRS and Akt.
In addition , in population-based studies , cannabinoids reduced dementia-related symptoms ( e.g. , behavioral disturbances ) .
In addition , insulin appears to act as ' neuromodulator' , influencing release and reuptake of neurotransmitters , and improving learning and memory.
In addition , interaction models were used to examine whether education modified the relation between neuropathologic indices and cognition.
In addition , interleukin-1β , tumor necrosis factor-α , glial fibrillary acidic protein and CD11b were increased.
In addition , international guidelines and recommendations for pain management have been collated , and important developing research areas are highlighted.
In addition , intervention approaches that have demonstrated efficacy are summarized along with ways to coordinate services across multiple service delivery sectors.
In addition , Intervention group participants received eight cookies daily ( @number@ g protein ; @number@ kcal ) for @number@ weeks ( w0-w6 ) .
In addition , intrusion effects in the deletion condition were larger in older than in younger adults.
In addition , in vitro cultures showed that the effect of AGEs on cell viability was different for AECs and fibrotic fibroblasts.
In addition , IOP was positively associated with systolic blood pressure and heart rate.
In addition , irradiated hMSC were labeled with a vital CMRA dye and co-cultured with non-irradiated bystander hMSC.
In addition , it has been shown that the levels of intracellular Aβ depend on neuronal activity.
In addition , it is advisable to confirm the placement of distinct visual markers on the way to the bathroom.
In addition , it is considered that vitamin D is involved in all of its etiologies , and attention to vitamin D is necessary.
In addition , it is known that Wnt signaling is antagonized by the protein klotho.
In addition , it is necessary to improve H. pylori eradication therapy in younger patients.
In addition , it is not known whether the effects of PA on brain function differ or overlap with those of CRF.
In addition , it is recognized that TGF-β1 plays a central role in the development of renal fibrosis.
In addition , it is recommended that the diverse needs of these specific end-users be considered in the design and development of this technology.
In addition , it is still unclear which stages of neural processing are altered by rTMS.
In addition , it remains to be seen whether targeting ER stress and the UPR could have therapeutic benefit.
In addition , its activity varies with arousal state and its interactions with other brain networks may be important for conscious awareness.
In addition , its expression was inversely correlated with LA size.
In addition , its lack of integrity can cause overproduction of reactive oxygen species.
In addition , its reliability was assessed in terms of internal consistency and stability.
In addition , its short lifespan and importance in the field of aging make it an ideal organism for modeling age-related neurodegenerative disease.
In addition , it underscores the importance of measurement considerations.
In addition , it was significantly correlated with the severity of elastic fragmentation , hypertension , and smoking , and particularly with advancing age.
In addition , Japanese men reported events related to work and retirement as the most important life events.
In addition , Kangen-karyu showed neuroprotective effects by attenuating the spatial memory impairment and neuronal death induced by diabetes.
In addition , knockdown of the AICD-binding partner Fe65 reduced PGC-1α mRNA levels.
In addition , knockout of CSB impairs the ATM- and Chk2-mediated DNA damage responses , promoting a premature entry into mitosis.
In addition , lactate carries signals as a volume transmitter.
In addition , larger switch costs reflected a binding effect with facial emotion as compared to age.
In addition , LDL , total cholesterol and self-management outcomes significantly improved.
In addition , leaflet tissues from hypertensive individuals also exhibited a higher stiffness and low areal strain than normotensive individuals.
In addition , LGN asymmetry as well as LGN atrophy along with age is observed in normal controls.
In addition , Li-ESWT was applied to cultured Schwann cells and endothelial cells to study the molecular mechanism involved in cell proliferation.
In addition , life-span studies in mice are not well suited to testing drug combinations that target multiple factors involved in aging.
In addition , lipid and glycogen content was increased in Ngb-overexpressing HT-22 cells.
In addition , lipogenic gene expression is higher in human colorectal tumor tissue compared with control colorectal tissue.
In addition , little information is available on appropriate dosage for intravenous usage.
In addition , losartan significantly reduced telomere shortening and cell senescence.
In addition , loss of CD62L , a marker of PMN activation , was reduced in PMN of older adults stimulated through multiple pathways.
In addition , low drug responsiveness and intolerable side effects are major challenges in the prevention and treatment of senile diseases.
In addition , lower affect balance was associated with more frequent contact with children.
In addition , lowering the transfusion threshold is another method used to decrease the rates of allogeneic blood transfusion.
In addition , low / medium use of disinfectants was associated with remittent asthma ( OR @number@ @percent@ CI @number@ to @number@ ) .
In addition , M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases.
In addition , major variation was seen between regions and countries , with overall prevalence varying between @number@ and @percent@.
In addition , male aging results in decreasing sperm morphology.
In addition , males are more prone to this disease than females ( @percent@ and @percent@ respectively ) .
In addition , males were likely to have a later age of onset than females.
In addition , many men start a second family later in life.
In addition , many more Dutch than Turkish elders were single / widowed / divorced.
In addition , many natural compounds have the potential to target numerous different components of the secondary injury.
In addition , many patients find it difficult to raise sexual issues with their doctor.
In addition , many phytochemicals can extend longevity in heterotrophic organisms across phyla via evolutionarily conserved mechanisms.
In addition , many sleep conditions are associated with an increase in morbidity and mortality.
In addition , many surgeons perceive a steep learning curve and difficulty of reliably obtaining excellent cosmetic results.
In addition , many ubiquitin-dependent mechanisms have been shown to regulate innate immune responses and xenophagy.
In addition , mast cells participate in lipid retention and vascular cell remodeling , and are mediators of innate and adaptive immunity during atherosclerosis.
In addition maximum expiratory and inspiratory pressure , mobility of the diaphragm and diaphragmatic thickness were evaluated by ultrasound.
In addition , measurements of pupil diameter indicated that changes in orientation discrimination were not associated with changes in retinal illuminance.
In addition , mechanisms leading to thymic atrophy during ageing as well as during various stress conditions are reviewed.
In addition , melatonin improves colonic transit time in constipation-predominant IBS patients.
In addition , memory for target information was unrelated to factors of episodic cognition.
In addition , men seem to benefit more from leisure-time physical activity than women.
In addition , metabolic memory determines a durable effect of hypoglycemic treatment that is much longer than the period of therapy.
In addition , MHY-449 induced increase of late apoptosis and sub-G1 DNA which were observed by flow cytometry analysis.
In addition , mice with their circadian rhythm chronically impaired by alteration of the light-dark cycle also develop such diseases.
In addition , microcirculatory changes have been suggested , however remain largely unknown in a controlled clinical setting.
In addition , microfluidic systems offer other advantages such as the possibility to create in vivo-like microenvironments.
In addition , microglia seems to develop characteristics that could be related to cellular senescence post-HIV-1 infection and after exposure to HIV-1 viral proteins.
In addition , micro-perfusion alteration in the patellar fat pad , femur and tibia subchondral bone will be assessed via dynamic contrast-enhanced MRI.
In addition , microvascular rarefaction is related to increased inflammatory signals that may negatively regulate the stem cell population.
In addition , miR-29b silencing prevented JunD-induced repression of IEC proliferation.
In addition , mitochondrial superoxide generation has been shown to play an important role in the formation and accumulation of AGEs under diabetic conditions.
In addition , mitochondria sense the status of metabolism and change their functions to regulate energy production , cell death , and thermogenesis.
In addition , modified and impaired proteins can cross-link and form the bases of many senescence-associated alterations and also of neurodegenerative diseases.
In addition , more dammarane triterpenoids with good biological activity , especially the aglycones possessing novel side chain , should be prepared using chemical modification.
In addition , more MHV participants found that participating in the original study was helpful for changing health behaviors.
In addition , more mitochondrial heteroplasmic mutations were detected in eyes with AMD.
In addition , more patients are requiring critical care services and physician numbers are not keeping with this growing need.
In addition , more pronounced glycation in vivo would be driven by elevated oxidation processes.
In addition , more women were nursing home residents , with a higher rate of voiding with diapers and antithrombotic use than men.
In addition , most of the NC members ( @percent@ ) were satisfied with Herbalife NC membership for themselves and their families.
In addition , motor neuron counts and soma sizes were recorded.
In addition , mounting evidence suggests that most mtDNA mutations may be generated by replication errors and not by accumulated damage.
In addition , MTs as free radical scavengers inhibit Charnoly body ( CB ) formation to provide mitochondrial neuroprotection in the aging brain.
In addition , multigroup LCA was conducted based on gender and age categories.
In addition , multiple signal transduction pathways need to be affected to result in AD instead of physiological aging.
In addition , multivariable analysis disclosed that cTnI hs-ARCH is influenced by the level of renal function at the minimum among the @number@ methods.
In addition , muscle volume and PCSA correlated with BMI , body mass and fat mass.
In addition , mutant FUS expression can alter the dynamics and morphology of stress granules.
In addition , MWT allows quantifying distinct low- and high-frequency oscillators in the human retina , which complement traditional OP analysis methods.
In addition , NAM attenuated the expression of the assessed senescence phenotypes , excluding irreversible growth arrest.
In addition , negative content produced a larger number of errors than positive content across groups.
In addition , neither young nor older adults were more likely to confuse self with close others than with unknown others.
In addition , neuronal loss and lipofuscinosis in the VPM / VPL and disrupted myelination in the cerebral cortex were observed in aged PGRN-deficient mice.
In addition , neuropsychological functions , self-focused attention , and depressive symptomatology were also assessed.
In addition , new anticancer therapies have substantially improved the prognosis of cancer patients.
In addition , newborn neurons in the hippocampus may play an important role in E2-mediated antidepressant like effect after ischemic stroke.
In addition , new breakthroughs for the management of hormone-receptor-positive disease in the metastatic setting have recently been reported.
In addition , new nonclinical bone age applications are evolving , particularly pertaining to immigration and children's rights to asylum.
In addition , new photograph-based grading criteria of sagging severity at the lower eyelid were established and used.
In addition , new therapies to treat and slow CKD progression are needed for all age groups.
In addition , NHs should consider a person-centered approach to pain that is culturally competent given the cultural influences of both residents and staff.
In addition , nitric oxide modulates BBB permeability.
In addition , nitrite derived from nitrate in the diet has been shown to decrease blood pressure and improve exercise performance.
In addition , no gray matter asymmetry differences were found between cognitively stable participants and participants who showed cognitive decline.
In addition , no information is available on the natural history of adenomyosis and no study has systematically evaluated its existence in adolescents.
In addition , nonconventional model organisms will be useful in answering the question how relevant the OSTA could be for life history evolution.
In addition , none needed discontinuation of the drug.
In addition , no significant correlation was detected between the NI-BUT and age ( @number@ p = @number@ ) .
In addition no statistically significant difference was demonstrated in both questionnaires scoring between younger and older subjects.
In addition , novel technologies and ultraviolet filters are improving the aesthetics and efficacy of modern products.
In addition , Nox5 silencing increased apoptosis of PC-3 cells.
In addition , NR4A receptors are components of DNA repair machinery and promote DNA repair.
In addition @number@ adults with DS and their parents / caregivers from a cross-sectional study were included.
In addition , @number@ CpGs in close vicinity of these SNPs constitute a weak CpG island.
In addition , @number@ datasets of different cancer types from The Cancer Genome Atlas were considered.
In addition , @number@ healthy male volunteers ( 20-70 years , body mass index ≤ @number@ ) were enrolled.
In addition , ( @number@ ) H-α-tocopherol half-lives were correlated with lipids ( r = @number@ P = @number@ ) .
In addition , @number@ intrapetrous ICAs ( @percent@ ) showed strong enhancement.
In addition , @number@ missense variants within the CR1 gene were selected to be genotyped in a total of @number@ individuals.
In addition , @number@ of the @number@ CpGs with age-related methylation in normal breast were significantly differentially methylated between normal and breast tumor tissues.
In addition , @number@ participants ( @percent@ ) had a misunderstanding in indication , dose , or frequency in a cardiac medication.
In addition , @number@ patients with acute myocardial infarction and chronic myocardial infarction were analyzed in a cross-sectional study ( Cohort B ) .
In addition , @number@ ( @percent@ ) were rated by physicians as important for patients ' medical care.
In addition , @number@ prevented downregulation of PPARβ / δ activity in aged rat skin and UVB-induced fibroblasts.
In addition , @number@ relatively rare , additional genes known to cause familial FTLD are examined in brief.
In addition , nutrient restriction is implicated in decreasing cancer initiation and progression.
In addition , occlusal disharmony impairs hippocampal memory processes via chronic stress , and induces similar hippocampal pathology.
In addition , oenothein B induced GM-CSF production by human adult T cells , but not cord blood T cells.
In addition , old adults drifted forward while SIP without any imposed visual stimulation.
In addition , older adults exhibit greater EMG burst and lower EMG burst variability as well as lower coactivation of the antagonistic muscles.
In addition , older adults had smaller anterior CC size and poorer white matter integrity in the callosal midbody than their younger counterparts.
In addition , older adults may rely more extensively on proprioceptive feedback to guide upper limb movement compared with younger adults.
In addition , older adults will manifest very different signs and symptoms related to development of an infection in the body.
In addition , older age , female sex , hypertension , and more severe ACS status were associated with certain aspects of sleep disturbance.
In addition , omeprazole reduced tyrosinase protein abundance in the presence of cycloheximide , suggestive of increased degradation.
In addition , online databases will be checked for observational studies published outside the time frames of previous reviews.
In addition , only in psychotic AD patients , all BPSD and types of agitation were more severe compared to non-psychotic AD patients.
In addition , only @percent@ ( @percent@ CI @percent@ to @percent@ ) of the existing cell population turns over from middle age and onward.
In addition , OP patients also had lower TAS levels than controls , which represent the oxidative imbalance.
In addition , OSDI score dropped significantly from a mean of @number@ ( ± @number@ ) to @number@ ( ± @number@ ) .
In addition , osteoblast-specific Smad1 overexpression had beneficial effect on bone formation during aging , which could be counteracted after overexpressing Plekho1 within osteoblasts.
In addition , other features of immunosenescence may result from the chronic immune stimulation that occurs in RA and lead to worsening of the disease.
In addition , other widespread Achyranthes species like A. japonica and A. rubrofusca ought to be studied.
In addition , our analysis identified unique social network types related to religious activities.
In addition , our colocalization study showed that within the same nuclei , 5mC and 5hmC mostly do not coexist.
In addition , our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height.
In addition , our functional analyses by overexpression and knockdown of CLDN8 mRNA indicate that CLDN8 promotes prostate cancer cell proliferation and migration.
In addition , our model provides a unique tool for identifying new targeted molecules intended at improving the appearance of aging skin.
In addition , our model suggests that the experimentally observed high interindividual variance in HSC numbers originates in a variance of histone methyltransferase activity.
In addition , our previous study demonstrated that relaxin is beneficial to skeletal muscle healing by both promoting muscle regeneration and preventing fibrosis formation.
In addition , our research indicated the limited research on ageing in low-and-middle income countries.
In addition , our studies revealed that the suboptimal maternal diet amplifies the age-associated epigenetic silencing of this locus.
In addition , our study suggests that reproductive aging contributes to QOL in the setting of irregular menses and likely profound impairment of ovarian function.
In addition , overweight / obesity was assessed by body mass index.
In addition owing to BBB disruption dendritic cells and T cells also penetrate into the brain where they take up a perivascular position.
In addition , p16 increased but Klotho decreased with progression of tubular atrophy / interstitial fibrosis.
In addition , p53 regulates autophagy to provide cell metabolites for surviving through damage regulated autophagy modulator ( DRAM1 ) .
In addition , pain-related transcripts such as TRPV1 , ASIC3 and CGRP were significantly up-regulated in sensitive skin , compared with non-sensitive skin.
In addition , participants felt that a single-user , smaller , portable device would be more useful than a non-portable multi-user device.
In addition , participants reported self-rated clarity of their MI in both tests after each trial.
In addition , participants were asked about their need for assistance with everyday household tasks and personal care.
In addition , partnered individuals reported lower levels of attachment anxiety and avoidance compared to single individuals , particularly in younger and older adulthood.
In addition , partners of patients in the case group were matched with partners in the corresponding control group.
In addition , path analysis was used to establish the influence of personality traits on somatization and social inhibition.
In addition , patients reported good satisfaction after a full-face approach.
In addition , patients with CI showed enhanced intracortical facilitation relative to controls , in the absence of changes in intracortical inhibitory measures.
In addition , patients with epilepsy received an annual mean excess social transfer income of €4 , 194.
In addition , patterns of cell death pathways activated following cerebral ischemia are distinct between males and females , but independent of steroid hormones.
In addition , PAX7 mRNA expression was lower in older subjects ( P < @number@ ) .
In addition , PD risk increased cumulatively with the increasing number of variants ( odds ratio for carrying @number@ variants , @number@ ) .
In addition , PEAL induces caspase-dependent apoptosis at least in part through the inhibition of phosphatidylinositol 3-kinase ( PI3K ) / Akt signaling pathway.
In addition , PEAL suppressed Akt activity and the PEAL-induced apoptosis was significantly attenuated in Akt-overexpressing U937 cells.
In addition , pentosidine levels in patients with asthma were closely correlated with each of these variables.
In addition , perceived family's life satisfaction was more related to self-life satisfaction for Chinese than for Americans.
In addition , perceived stress moderated the sleep-CD8 + telomere association.
In addition , @percent@ of intervention group participants and @percent@ of control group participants were lost to follow-up at @number@ months.
In addition , @percent@ scored below the age- and education-specific cutoff values for probable dementia based on the MMSE-KC.
In addition , @percent@ was attributable to sex difference , but we found no detectable contribution of genetic factors to inter-individual variation in ICT age.
In addition , performance-related functional connectivity of lower- and higher-order motor networks differed between patients and controls.
In addition , pharmacokinetics and pharmacodynamics unique to the geriatric population make this group vulnerable to adverse medication effects.
In addition , pharyngeal clearing during swallow is reduced with aging.
In addition , physical training enhances the levels of insulinlike growth factor , which has a very positive effect on bone formation.
In addition , pioglitazone treatment resulted in a decrease in fasting plasma insulin levels , indicating enhanced insulin sensitivity.
In addition , plasma BDNF was not significantly associated with either hippocampal volume or memory in either cohort.
In addition Poly Herbal formulation @number@ also had better anti-cancer activity in human malignant melanoma cells.
In addition , polypharmacy-an issue more common in older adults-increases the complexity of prescribing and risk of adverse events.
In addition , PolδD515V does not increase the mutation frequency in MMR-proficient cells.
In addition , poorer performance on the sustained attention task was associated with more falls over @number@ months.
In addition , positive attitudes toward aging were found to reduce computer anxiety.
In addition , possible associations between MeDi's eight dietary features and cognitive functioning and brain volumes were investigated.
In addition , potential differences in host-gene-microbial interactions according to age are highlighted.
In addition , PPARγ activated strong mitochondrial activity and cell viability in aging cells.
In addition , practitioners should avoid prescribing multiple-drug therapies that have overlapping pharmacodynamics or that may have an adverse pharmacokinetic interaction.
In addition , prion protein in the CSF was slowly amplified by the RT-QUIC assay.
In addition , procollagen type I protein and mRNA expression increased , which accounts for the increased dermal collagen density.
In addition , proteins shown to be differentially regulated by both glucose and serum restriction were similarly regulated.
In addition , psychosocially chronically stressed mice exhibited a shortened life span and accelerated cognitive dysfunction.
In addition , PT , NA , RTD , and EMD can be assessed with ballistic contraction in older adults.
In addition , PTX-3 decreased as the number of metabolic factors increased , whereas hs-CRP increased as the number of metabolic factors increased.
In addition , published databases of mouse and human retinal pigment epithelium-choroid were evaluated and CD34 expression compared between young and old eyes.
In addition , quality of life in children following heart transplantation was compared with previously reported values in children with congenital heart disease.
In addition , quantitative monitoring was performed by extracting the relevant photothermal parameters from the PT response.
In addition , race differences in pain sensitivity observed in younger adults were also found in our older sample.
In addition , radiographic severity was classified according to Kellgren-Lawrence's criteria.
In addition , Raman features sensitive to the elasticity and the fatigability of the SC were highlighted.
In addition , randomized controlled trials show that protein's positive effect on bone health is augmented by increased calcium intake.
In addition , range and cause of diseases varies considerably within age groups.
In addition , Ras protein levels were increased in PBMCs from old donors.
In addition , reaction time was assessed after both @number@ and @number@ weeks of intervention.
In addition , receiver operating characteristic curve analysis revealed higher diagnostic accuracy for recognition test with emotional stimuli than with neutral stimuli.
In addition , recent clinical intervention studies performed with resveratrol are summarized.
In addition , recent research has noted an increased incidence of dementia in veterans with PTSD.
In addition , recent studies have indicated that senescence is a multi-step evolving process related to important complex biological processes.
In addition , RecQL4 knockout cells were more susceptible to apoptosis under mitochondrial stress than the control cells.
In addition , redox signaling mechanisms that control O2 ( -• ) / H2O2 genesis from these sites are discussed.
In addition , reduced affect complexity seems more likely from a theoretical point of view.
In addition , reduction of PVR is shown early and late after the Fontan procedure on treatment with exogenous NO , another advanced PAH therapy.
In addition , residents with a diagnosed mental disorder and no dementia incurred relatively high expenditures for ACS hospitalizations.
In addition , results driven by single erroneous probes are removed.
In addition , retardation was significantly reduced in abdominal aortas with AAA at the level of the inferior mesenteric artery.
In addition , Rev-erbα levels decrease in the first hours of fasting.
In addition , RIPK1 was shown to exhibit kinase activity-independent functions that are essential for preventing cell death , maintaining tissue architecture and inhibiting inflammation.
In addition , RT-PCR array-based evaluation of the expression of genes related to DNA damage signaling pathways was performed.
In addition , rural males and older females with higher level of education were more likely to consume alcohol.
In addition , rural newspapers were more likely than urban newspapers to publish stories about aging , specifically arthritis and heart disease.
In addition , sandy wind pollution may also contribute to it.
In addition , satisfaction with interactions was significantly positively related to task-tracking devices and negatively related to rapport-building devices by older adults.
In addition , scopoletin modulates the reprogramming proteins.
In addition , searches were carried out with Google.
In addition , self-assessment scores of spatial domain in the SSQ questionnaire were significantly improved after the operation.
In addition , senescent cells with critically short telomeres produce pro-inflammatory factors.
In addition , several lines of evidence indicate the impact of mitochondria in lifespan determination and ageing.
In addition , several mitochondrial chaperone proteins have been shown to be substrates of the PINK1 kinase.
In addition , several ongoing studies that were designed to address these limitations are reviewed.
In addition , several peer-reviewed , refereed medical and dental journals were consulted.
In addition , several trials with the exercise intervention indicated improvement in motor function , suggesting exercises could prevent the locomotive syndrome.
In addition , sexual function ( using the Female Sexual Function Index ) and quality of life ( using the Cervantes Scale ) were assessed.
In addition , short-interval intracortical inhibition ( SICI ) is reduced in old but not young adults , but only after visuomotor practice.
In addition , Shyness and Sociability were positively related to activity in the periaqueductal gray region during humor processing.
In addition , sialidase modified the N-glycan of transferrin , a model glycoprotein , differently from klotho.
In addition , similarities and dissimilarities are presented.
In addition , similar to BMP2 , curcumin induced the phosphorylation of Smad @date@ .
In addition , since reactive oxygen species are a cost of mitochondrial oxidative phosphorylation , this demands safeguards as protection from these harmful byproducts.
In addition , single-items : general health , satisfaction with life , tiredness , low-spiritedness , worries / anxiety and sleeping were used.
In addition , Sirt2 overexpression induced cellular apoptosis via up-regulating cleaved caspase @number@ and Bax , and down-regulating anti-apoptotic protein Bcl-2.
In addition , SIRT6 activators are attractive candidates for Alzheimer's disease ( AD ) due to the protection effect of SIRT6 overexpression from DNA damage.
In addition , site- and stage-specific analyses were performed.
In addition , SKI-II reduced cigarette smoke mediated oxidative stress , macrophages and neutrophil infiltration and markers of inflammation in mice.
In addition , sleep-deprived individuals looked sadder than after normal sleep , and sadness was related to looking fatigued ( P < @number@ ) .
In addition , Snail1 was identified as a direct target of miR-30c by Ago2 co-immunoprecipitation , luciferase reporter , and Western blot assays.
In addition , social closeness and geographical proximity mattered.
In addition , social factors affect the progression of frailty ; thus a more comprehensive approach is needed , including social participation.
In addition , social support from friends / co-workers had greater influence on successful aging than social support from family.
In addition social support , physical functioning and the presence of chronic diseases were assessed.
In addition , some athletes have an underlying susceptibility to fracture due to either systemic or focal abnormalities.
In addition , some drugs commonly prescribed for the treatment of depression may worsen insomnia and impair full recovery from the illness.
In addition , some EMs had interesting histological features , such as harboring many small arteries , calcified debris , and metaplastic bone fragments.
In addition , some of the microRNA patterns may have prognostic significance.
In addition , some patients had long survival with a good response.
In addition , some possible mechanisms of the age-related defects will be discussed.
In addition , SorCS1 influenced APP processing.
In addition , spatial scan statistics and spatial analysis were utilized to identify the spatial pattern and to map the clusters.
In addition , SSAO enhances Aβ1-40 D and Aβ1-42 deposition on vascular cells by both activity-dependent and -independent mechanisms.
In addition , SSRIs users had significantly higher dementia risk than non-users with severe depression ( HR = 2.26 , P = 0.0005 ) .
In addition , SSTR1 knockdown specifically resulted in reduced neuronal apoptosis in PC12 cells.
In addition , standard time and frequency domain measures were also computed.
In addition , states should increase home and community-based services , particularly in markets with low community discharge rates.
In addition , stiffness effects due to sex exist in the occipital and temporal lobes.
In addition , stressful dilemmas arise for physicians encountering DDIs because of difficult treatment decisions.
In addition , stronger learning of rewarded associations over unrewarded associations was significantly correlated with smaller skin-conductance responses for HCs but not PD patients.
In addition , structured assessments of depressive symptomatology , fatigue , and general behavioral / neurovegetative symptoms were performed.
In addition , studies comparing long-term health conditions between patients with childhood- and adult-onset craniopharyngioma report conflicting results.
In addition , studies of tissue-specific SIRT3 knockouts suggest non-tissue-autonomous roles for SIRT3.
In addition , subjects who were actively engaged in NLTPA had a lower mortality risk especially in subjects without performing LTPA.
In addition , subjects with disability had a worse self-reported health status.
In addition , subtle changes in HPA axis activity are associated with cardiovascular risk factors.
In addition , support was found for two potential explanations.
In addition , surgery itself is of growing importance in lung cancer treatment.
In addition , sustainable and efficient methods for fostering long-term partnerships will be identified between community and academia.
In addition , T1-weighted MRI data were acquired to determine muscle cross-sectional areas ( CSA ) and to assess fat infiltration into muscle tissue.
In addition , tangible support significantly predicted WCST performance.
In addition , TDP-43 demonstrated an unusually high tendency to aggregate , a property intrinsic to the WT protein.
In addition , telomere repeat binding factors TRF1 and TRF2 do not impair OGG1 incision activity.
In addition , telomeres are sensitive to inflammation and oxidative stress , which can further promote telomere shortening.
In addition , tenuigenin protected mitochondrial membrane potential ( MMP ) against 6-OHDA damage and significantly increased glutathione and superoxide dismutase expression.
In addition , testosterone was correlated with MD in these pubertally significant regions.
In addition , text-based screening tools lose users ' attention easily.
In addition , TGF-β levels are associated with increased risk of CV events and mortality.
In addition , TG males showed higher expression of mTOR in the liver.
In addition , the accuracy of CTA for detecting coronary anatomy and obstruction will be assessed in patients who subsequently undergo both CTA and ICA.
In addition , the ACOVE QIs depend on patient and caretaker interviews to assess the quality of care.
In addition , the actions by which glucocorticoids , CRH and VP can affect the aging process will be discussed.
In addition , the advantages of using an interactive system and animation have been shown to lead to positive effects on learning in medical research.
In addition , the aMCI group had less day-to-day variability in these measures than the intact and naMCI volunteers.
In addition , the AMPK-mediated inhibition of p-tau396 expression was attenuated by okadaic acid , a protein phosphatase 2A ( PP2A ) inhibitor.
In addition , the ANL did not predict hours or pattern of hearing aid use.
In addition , the application of statins as a local drug delivery system in the treatment of periodontitis was described.
In addition , the association between state educational and training requirements and quality of nursing home care is examined.
In addition , the association of neocortical Lewy bodies with terminal cognitive decline was attenuated in those with higher conscientiousness.
In addition , the associations between changes in loneliness with health are less well known , especially in the case of aging people.
In addition , the associations of OGT and OGA gene expressions with muscle phenotype were analyzed.
In addition , the astrocyte marker , glial fibrillary acidic protein ( GFAP ) , was studied in association with AQP4.
In addition , the ATR will address twin-specific questions.
In addition , the average Pfirrmann disk score was @number@ at levels with retrolisthesis indicating that the disks were not severely degenerated.
In addition , the brainstem mediated the effect of age on postural control , underscoring the brainstem's fundamental role in aging.
In addition , the C677T-MTHFR association adds further support to existing findings underscoring the potential role of folate in depression.
In addition , the causality hypothesis assumes that there is a critical telomere length at which senescence is induced.
In addition , the C-G-C haplotype at SNPs @number@ through @number@ was associated with AD risk ( P < @number@ ) .
In addition , the changes of co-regulated microRNA expression were validated by quantitative real-time PCR.
In addition , the cholesterol content in Lp ( a ) is not a significant predictor of CHD risk.
In addition , the clinical changes achieved with tretinoin are accompanied by histologic evidence of benefit.
In addition , the conditioned medium leads to a decrease in the expression of RORα and its target genes.
In addition , the control group consisted of @number@ patients.
In addition , the coordination of the agonist and antagonist muscles ( TA and SOL ) was different between the two age groups.
In addition , the correlation between serum HA level and the degree of knee pain was analyzed in each group.
In addition , the cumulative frequency distributions of raw score changes were examined to describe the base rates of test score changes.
In addition , the data indicate that older people with high hostility scores help others less often and are less grateful.
In addition , the data revealed that perception and expression of depressive feelings was different between male and female elderly people.
In addition , the decreased number of JSTB members has returned to increase significantly.
In addition , the direction of the activation with problem size within the IPS was associated with differences in accuracies for small subtraction problems.
In addition , the disappearance of anti-Dsg3 B-cell clones in two patients during long-term rituximab-induced remission supports the therapeutic potential of rituximab.
In addition , the discourse of Research reports on older people's health was found , although less significant compared to the two major discourses.
In addition , the drug alters learning performance in several assays related to episodic , working and spatial memory.
In addition the drug has symptomatic effects on some aging traits , such as age-related cognitive impairments.
In addition , the effect of carrying an ε4 allele on individual cognitive domains was assessed in separate meta-analyses.
In addition , the effects of melatonin supplementation on the production of endogenous melatonin and its precursor serotonin are suppressed.
In addition , the effects of the lens and curvatures of the human eye on focusing are analyzed.
In addition , the empirical literature related to Tai Chi Chuan and cognition is reviewed.
In addition , the enhanced ROS production and its associated pathophysiological pathways will be discussed along with the MSC senescence process.
In addition , the ERK inhibitor PD98059 reduced HAS2 expression.
In addition , the existing scientific knowledge needs to be updated , but also critically evaluated and simplified for newcomers and wine industry partners.
In addition , the expanded cells are shown to be useful for therapeutic vasculogenesis.
In addition , the experimental group received three cycles of @number@ active MT sessions each , three times a week.
In addition , the expression of the ( G4C2 ) 102 repeat shows cellular toxicity.
In addition , the expression pattern of miR-526b and MMP1 mRNA showed reverse relation between adult dermal and neonatal fibroblasts.
In addition , the expressions of Nrf2 downstream gene targets , including HO-1 and NQO1 , were also promoted by apigenin administration.
In addition , the expressions of α-kl mRNA and α-Kl protein were severely reduced in these patients.
In addition the F-actin content was increased keeping the total actin content unaltered.
In addition , the fecal lipopolysaccharides ( LPS ) content was significantly higher in UTC than in LVC.
In addition , the findings provide support for action observation as a more effective technique for movement reproduction in comparison to imagery.
In addition , the first CpG island of the ATXN3 promoter served as the main regulation region of DNA methylation.
In addition , the fit of different life course models ( sensitive periods / accumulation ) were compared using partial F-tests.
In addition , the fMRI activation increase in the left VLPFC was associated with longitudinal increases in response latencies.
In addition , the focus groups highlighted key design considerations of visualizations important towards supporting decision-making and evaluation assessments within integrated health displays.
In addition , the frequency of falls among women is much higher than in men.
In addition , the frequency of use of the different strategies varied with participants ' age.
In addition , the genes and signaling pathways which regulate this process in MSCs are still unknown.
In addition , the genome-wide response to blood neutrophils ( rather than total WBC ) was also not well correlated between humans and mice.
In addition , the guardian ad litem should be an attorney or a registered nurse.
In addition , the heart rate ( HR ) and the Borg rating of perceived exertion scale value are recorded per minute.
In addition , the Hippo pathway contributes to progenitor cell and stem cell self-renewal and is thus involved in tissue regeneration.
In addition , the hydrophilic nature of adhesive systems creates problems that lead to suboptimal hybrid layers.
In addition , the impact of simulated cataract was significantly greater in this older cohort than in a younger cohort previously investigated.
In addition , the implications of these different measurement tools on study results were evaluated and discussed.
In addition , the importance of sugar to provide palatability to the diet is also revised and attempted.
In addition , the improvement was significantly higher in the I group than the NI group.
In addition , the increasing use of new immune modulating drugs in cancer therapy has opened an entirely new spectrum of at risk periods.
In addition , the influence of aging time ( up to @number@ days ) on potential interactions was also investigated.
In addition , the influence of support from fellow church members on health behaviors is greater for study participants who closely identify with their congregations.
In addition , the influence of these manipulations on groups aged under and over @number@ years was explored.
In addition , the inhibition of mitochondrial fission leads to increased lipofuscin formation.
In addition , the innate immune response will always be present after transplanting cells into the brain.
In addition , the insulin receptor inhibitor , S961 , decreases the amount of insulin transported throughout the brain after intranasal injection.
In addition , the intervention included regular musical exercises at home.
In addition , the intraclass correlation coefficient ( ICC ) and standard errors of the measurement ( SEM ) were calculated for test-retest reliability.
In addition , the introduction of lamin Δ50 , known as Progerin , caused senescence in these neuroblastoma cells.
In addition , their potential to suppress lymphocyte proliferation and susceptibility to natural killer cell lysis was examined.
In addition , their results are frequently published only incompletely or some time after the end of the clinical study.
In addition , the isocapnic buffering ( IB ) phase was calculated together with the hypocapnic hyperventilation.
In addition , the known pressure dependency of arterial stiffness results in a curvilinear relationship between blood pressure variability and mean pressure.
In addition , the lack of maturity in the immune system in newborns and infants also results in more severe disease outcomes.
In addition , the latency of P13 and N23 was prolonged , while the thresholds worsened with increasing age also after @number@ years.
In addition , the length of myelinated axons is greatly reduced , up to almost @percent@.
In addition , the length of telomeric G-tails decreases in DNA-PKcs knockdown cells , and this phenotype is reversed by overexpression of WRN helicase.
In addition , the less positivity for MUM1 ( P = 0.020 ) of EBV sBL was highlighted.
In addition , the likelihood of interactions between diseases ( disease-disease interactions , DDI ) and the complexity increases overproportionately with each additional disease.
In addition , the longer the husbands ( but not wives ) were retired , the worse was their SRH.
In addition , the low-memory believers performed more poorly at feature binding and ( at trend ) manipulating visuospatial information in working memory.
In addition , the main reasons which motivate participation in these musical activities are to broaden the social network and to acquire new knowledge.
In addition , the majority of psychiatric and mental disorders are polygenic , and many have onsets during childhood and adolescence.
In addition , the masseter and biceps differed in age-related changes of composition and distribution of fibre types between young age and adulthood.
In addition , the mass media is considered to have a crucial influence in shaping general perceptions of older people.
In addition , the mediational analyses revealed that changes in VA fully mediated the effects of exercise on TMT-Part A performance.
In addition , the medications used to treat systemic conditions may also themselves cause oral symptoms.
In addition , the mortality hazard rate among farmers decreases more as FEL increases than it does for non-farmers.
In addition , the Na content increased significantly in the left coronary arteries of both men and women with aging.
In addition , the NET BPND was evaluated in thalamic subnuclei ( @number@ atlas-based regions of interest ) .
In addition , the non-selective NADP ( H ) oxidase inhibitor apocynin improved the eNOS-H₂O₂ pathway only in 12-m / o ATX mice.
In addition , the novel putative HKGs identified in this study can preferentially be used for normalization of gene expression data obtained from differentiating hPSCs.
In addition , the nuclear translocation of FoxO3a from the nucleus to the cytoplasm was induced by SEA stimulation.
In addition , the number of abnormal scores at each of the seven cutoffs was also examined.
In addition , the number of general practitioners ( GPs ) has declined in the past years.
In addition , the older controls then identified the expression on the test face.
In addition , the older population usually experiences age-related muscle changes that affect muscle mass , muscular strength , and functional abilities.
In addition , the olfactory identification score did not differ between aMCI participants who were PiB-positive and those who were PiB-negative.
In addition , the overall appearance of the lower face and neck was evaluated by the Investigators and Subjects Global Aesthetic Improvement Score.
In addition , the participants of the experimental group evaluated their own pictures.
In addition , the pattern of CBF associations with age displays an interesting similarity with the default-mode network.
In addition , the peroxisomal volume density was increased in the soma of neurons in gyrus frontalis at advanced AD stages.
In addition , the personal subscale would benefit from additional research using IRT.
In addition , the possibility of using DRC as a simple screening tool for BC risk is explored.
In addition , the possibility of variable brain-cognition relationships in the CAE compared to the control group was investigated.
In addition , the potential application of miRNAs to clinical practice for the diagnosis and treatment of cardiovascular diseases will also be discussed.
In addition , the presence of age-associated dnNT in the normal brain remains unexplored.
In addition , the presence of multiple chronic conditions negatively impacts mortality rates in this vulnerable population.
In addition , the presence of this increased connectivity is seen to eventually weaken with disease progression.
In addition , the prevalence in each geographic area were estimated and mapped , which showed a large imbalance in the map.
In addition , the pro-inflammatory cytokines MCP-1 and TNF were increased in the serum of aged donors.
In addition , the proposed method is expected to be sensitive enough to detect smaller , previously undetected birth cohort effects.
In addition , the proteasome is directly associated with a thioredoxin and other cofactors that may adjust the particle's response during an oxidative challenge.
In addition , the psychological well-being of family members was repeatedly assessed with questionnaires.
In addition , the public health applications are potentially of tremendous impact in our ageing societies and raise important ethical questions.
In addition , the question has to be addressed whether meibomian gland loss could serve as a predictor for the development of ocular GvHD.
In addition , the randomized interventional trial will explore the relevance of the implementation of a supportive intervention by a social worker to help caregivers.
In addition , there are changes in the expression and plasma levels of important endothelial components related to endothelial-mediated modulation in hemostasis.
In addition , there are issues with the adverse effects of asthma medications , use of proper inhaler technique and compliance.
In addition there are potential synergies to support a neurorestorative role via glial derived neurotrophic factor expression.
In addition , there are several other examples where communication between the brain and immune system involves neuroinflammatory processes that are beneficial and adaptive.
In addition there are those cases where many alterations are seen in a sparse extent , but jointly they lead to a clinical syndrome.
In addition , there exist intricate associations among hormonal and lifestyle factors , %BF and age.
In addition , there have also been continued new HIV diagnoses ( and new HIV infections ) in those aged more than @number@ years.
In addition , there is an early presence of neurodegenerative changes in the late life stages.
In addition , there is a reduction in a RyR2 splice variant , associated with an antiapoptotic function , in MCI and AD brains.
In addition , there is increasing evidence that mitochondrial dysfunction plays an important role in OA pathogenesis.
In addition , the renal functional defects of acid-base homeostasis and electrolyte disturbances in elderly and the physiological basis of such disorders are also discussed.
In addition , the resulting three age-dependent models were validated by simulating cadaveric tests of blunt and sled impacts.
In addition , the results indicate an age-related decline in conflict adaptation.
In addition , the results of pyrosequencing in ejaculate samples were compared with that of DNA sequencing in tissue samples from the same patients.
In addition , the results show that there were also dysregulations in normal autophagy and apoptosis , mechanisms related to βA formation.
In addition , there was also a significant effect of the factor age.
In addition , there was a significant decrease ( P < @number@ ) in the CSA for the sartorius , quadriceps and rectus femoris muscles.
In addition , there was evidence of a similar factor structure for family history and APOE status groups.
In addition , there was good test-retest reliability of the PDQ-8.
In addition , there was no significant association between vitamin D supplementation and an improvement of the sit-to-stand test results in @percent@ of the studies.
In addition , there was relationship between expression of MMP-2 and MMP-1 , MMP-3 , MMP-9.
In addition , there was under-consumption of protein per mealtime , especially at breakfast and dinner.
In addition , there were no interactive effects of CVD and PiB retention ratio on cognition.
In addition , there were significantly higher IgE levels in later birth cohorts ( p < @number@ ) .
In addition , the risk of bleeding associated with anti-thrombotic therapy also needs to be considered during the anti-thrombotic therapy decision-making process.
In addition , the risk of cortical cataract increased @percent@ ( @percent@ CI @number@.1%-2.0% ) when cumulative UV-B exposure time increased every one year.
In addition , the role of other determinants , such as metabolic syndrome or prostate inflammation , is emerging.
In addition , the scholarly works of Michel Foucault were examined.
In addition , the Schwann cell origin of DFTD may enable tumours to respond to sex hormones , as occurs in similar cancers in humans.
In addition , these data can be used to help identify older women with functional losses , thereby assisting in the diagnosis of early disability.
In addition , these effects were sustained after @number@ weeks of detraining.
In addition , the selected miRNAs represent new potential therapeutic targets.
In addition , these mature men and women showed a significant impaired immune cell function , which is especially remarkable in the winter.
In addition , the SEM images suggested that the predominant failure type was not necessarily the same as for the failure propagation.
In addition , these molecules significantly increased the expression of seladin-1 and the amount of cell cholesterol.
In addition , these properties change with the balance between electrostatic and hydrophobic interactions and the intrinsic disorder of the system.
In addition , these results support the hypothesis that age-related increases in metabolic economy may decrease MIF.
In addition , the single earliest memory reported by children and adolescents was at a younger age than that reported by adults.
In addition , the specificity and accuracy obtained after the selection of @number@ sputum samples as the analyzed specimen reached @percent@ and @percent@ , respectively.
In addition , the spontaneous repair capacity of articular cartilage is limited ; thus , investigation into new cartilage replacement and regeneration techniques are warranted.
In addition , the strategies available to manipulate memory cells in Rhesus macaques to understand their trafficking and function will be discussed.
In addition , the stress accumulation in the AMC head was restricted at a quite low level throughout the aging simulation.
In addition , the strongest association overall was between the percentage decline in LH and non-SHBG estradiol concentrations ( r = @number@ ) .
In addition , the study explored the prognostic relevance of cTnThs in patients with cardiac and noncardiac syncope.
In addition , the study investigated relationships between mechanical directionality and ' skin sagging , ' which may be caused by gravity.
In addition , the study investigates the moderating influences of two variables : parents ' gender and stress from negative parenting experience.
In addition , the study tested the relevant contributions of the cognitive and emotional mechanisms to age differences in processing strategies.
In addition , the subjects recruited in this study underwent observational assessments through self-assessment questionnaires.
In addition , the subjects ' working memory and attentional abilities were measured.
In addition , the TEA domain ( TEAD ) family of growth-promoting transcription factors was indispensable for YAP-mediated regulation of autophagy.
In addition , the time-warp parameters provide useful information of underlying anatomical changes as demonstrated for the analysis of corpora callosa and rat calvariae.
In addition , the transcriptional levels of HERV-H , HERV-K , and HERV-W change significantly during the life span , albeit with distinct patterns.
In addition , the transfer to an untrained orientation and noise levels were examined.
In addition , the tumor volumes in subcutaneous nude mouse models in Beclin-1-deleted HOS cells were significantly smaller than those of control group.
In addition , the uncertainty of health care reform poses a challenge for public health leadership.
In addition , the usefulness of visceral abdominal fat area ( VFA ) to predict MetS in the elderly has not been studied yet.
In addition , the vascular ECs isolated from miR-34a knockout mice were resistant to HIV and antiretroviral agents-mediated senescence.
In addition , the views from a discussion with the participants of a session in the NHPR Conference @number@ are integrated.
In addition , the well-being of older care recipients and foreign home care workers was directly associated with their satisfaction with this arrangement.
In addition , they are associated with other clinical , functional and cognitive problems.
In addition , they are frequently occurring co-morbidities in dementia.
In addition , they can guide the development of new materials tunable to diabetic and non-diabetic arteries.
In addition , they change the tissue expression of RAAS components.
In addition , they completed a thought suppression questionnaire.
In addition , they contain more than @number@ unique polyphenols , avenanthramides , which have shown strong antioxidant activity in vitro and in vivo.
In addition , they discuss preprocedural and postprocedural considerations , potential complications , and their management to maximize patient outcomes and minimize risk.
In addition , they often did not look surprised in the trick condition.
In addition , the younger participants showed significant regions of task-induced deactivation , while no deactivation occurred in the elderly adults.
In addition , they point to the possibility of developing aging and cancer therapies based on telomere length manipulation.
In addition , they were less likely to report consumption of significant larger portion sizes.
In addition , this ability seems to share unique variance with reasoning.
In addition , this finding suggests that an abnormally high EBR may be a potential biomarker of the transition from healthy aging to dementia.
In addition , this individual shows signs of lumbar kyphotic deformity , spondylolisthesis , and Baastrup disease.
In addition , this pilot study should allow for the exploration of potential interactions between QoL , socioeconomic , health and oral health variables.
In addition , this positive correlation was stronger in the FN or TH than in the LS and was stronger in men than in women.
In addition , this predictive power has never been evaluated using subjective SES , which is an important measure of SES in elderly adults.
In addition , this program can be utilized to effectively provide diversified healthcare service benefitting society as a whole.
In addition , this protocol can be used to determine the effects of culture conditions or mutagen exposure on mutation accumulation in ASCs in vitro.
In addition , this ratio method allows smaller sample sizes for comparable statistical significance because of the relatively low variability of the ratio values.
In addition , this review provides the latest advances in the identification of gene variants affecting arterial stiffening.
In addition , this statin accelerated the production of cartilage matrix proteoglycan in chondrocytes.
In addition , this study presents the benefits of associating different active antioxidants substances in a single cosmetic formulation to prevent skin aging.
In addition , those PSWs perceiving support from their supervisor report lower work stress.
In addition , thresholds may vary between young and old men.
In addition , time domain features were primarily selected over frequency domain features.
In addition , TLRs are implicated in the regulation of behaviors including learning , memory and anxiety.
In addition , TNF-α also stimulated c-Jun and ATF2 phosphorylation which were inhibited by pretreatment with SP600125 and SB202190 , respectively , but not PD98059.
In addition to A2E , there are numerous components in RPE lipofuscin that are unidentified.
In addition to acute treatment , the organization of secondary fracture prevention is a crucial pillar of treatment.
In addition to AD cases , iAβ in pyramidal neurons was readily and reproducibly demonstrated in the majority of control cases.
In addition to age and stage , tumor grade and hormone receptor status were independent predictors of 5-year relative survival.
In addition to age , a significant gender effect was observed on gait symmetry.
In addition to age , developmental history and sex may provide further predictors in older individuals of decline on measures of motion discrimination.
In addition to age , genetic and environmental risk factors have also been associated with disease development.
In addition to age , HOA is known to be influenced by several factors , including pupil diameter , accommodation , and pupil shift.
In addition to a genetic predisposition , prenatal and early-life environmental exposures have a persistent impact on respiratory health.
In addition to age , ocular and corneal HOAs were mainly affected by corneal indexes.
In addition to alterations in the sleep architecture and sleep-wake rhythm , several sleep disorders become more prevalent in the elderly.
In addition to assessing several established predictors of residential mobility , data on objective living situations were collected.
In addition to Aβ , many proteins aggregate into the amyloid state , in which they form elongated fibers with spines comprising stranded β-sheets.
In addition to Aβ pathology , various lines of research have implicated neuroinflammation as an important participant in AD pathophysiology.
In addition to being highly prevalent in elderly population , frailty also exerts a substantial impact on quality of life.
In addition to calcium and vitamin D supplementation , previous studies have demonstrated a beneficial effect of dietary silicon on bone health.
In addition to cardiovascular disease , enhanced platelet activation has been detected in inflammatory disease and intestinal tumourigenesis.
In addition to circumferential stress , arterial wall contains residual stress with compressive and tensile components on intima and adventitia sides.
In addition to conspicuous local structural and vascular changes after stroke , there are many less obvious challenges in the imaging of stroke populations.
In addition to controlling disease risks , improvement of social connections may offer new insights to the reduction of mortality among older adults.
In addition to conventional cardiac surgery , surgical ventricular restoration was reported as a promising surgical therapy in 1990s.
In addition to conventional endpoints as response , quality of life should be carefully evaluated during each therapeutic phase.
In addition to dedicated roles , evidence suggests that Forkhead factors have retained some functional redundancy.
In addition to direct myocardial actions , central opioid receptor signalling may also enhance the ability of the heart to withstand I-R injury.
In addition to excretion of metabolic waste products , organic ionic transporters facilitate uptake of specific compounds of physiological importance.
In addition to exhibiting low levels of sialylation , GNE-deficient cells produced distinct
In addition to extending the period covered by @number@ years , this study estimated the effect of design changes by model year and vehicle type.
In addition to genital health complications , the medical community must confront an understudied concern of what happens as this population ages.
In addition to genuine hearing deficits , age-related declines in attentional and inhibitory control are assumed to contribute to these difficulties.
In addition to gray matter dysfunction , the plasticity and repair capacity of white matter also decrease with aging and contribute to neurodegenerative diseases.
In addition to group differences in material-independent regions , age-related crossover interactions for material-dependent source memory effects were observed in regions selectively engaged by objects.
In addition to growing evidence obtained by model animal experiments , extensive clinical examinations were performed or are under way.
In addition to IGF-1 , IGF-1R ( + ) hCSCs secreted IGF-2 that promoted myocyte differentiation.
In addition to illustrating the extent of dietary regulation of reproduction , findings from these studies have implications for fertility during aging or disease states.
In addition to items derived from existing measures , the investigators generated items thought to be particularly relevant for older adults.
In addition to its activity as an energetic metabolite , BHB is increasingly understood to have cellular signaling functions.
In addition to its function as a tumour suppressor , p53 is also involved in an increasing number of pathology associated with aging.
In addition to its genetic importance in human disease , ChlR1 is implicated in papillomavirus genome maintenance and cancer.
In addition to its high constitutive expression , recent studies have demonstrated that it is also inducible.
In addition to its high mortality ( 35-40% ) , survivors are left with cognitive , behavioral , and communicative disabilities.
In addition to its hypoglycemic effect , metformin has an anti-inflammatory function , but the precise mechanism promoting this activity remains unclear.
In addition to its special organization , the mitochondrial network of cardiac myocytes exhibits substrate-sensitive coupling constants and clustering coefficients.
In addition to its vascular fibrinolytic action , tPA exerts various effects within the brain , ranging from synaptic plasticity to control of cell fate.
In addition to its well-established role in tumorigenesis , p53 has also been associated with aging in mice.
In addition to LNFAT , LTPA , diabetes , CVD , walking speed , and other covariates were measured biannually over an 8-year period.
In addition to low muscle mass measurements , recent research has recognized the importance of muscle strength and physical performance.
In addition to mature miRNAs , we also examined the expression of precursors ( pri-miRNAs ) .
In addition to mediating locomotion , skeletal muscle is a secretory organ that contributes to metabolic homeostasis.
In addition to midface volumetric rejuvenation , alloplastic chin implantation can help strengthen and further define a retrusive chin and weak jawline.
In addition to mitochondria , lysosomes may also be involved in BAX-initiated apoptosis.
In addition to morphological changes different functional MRI techniques can help in the early diagnosis of dementia and the precursor stages.
In addition to negligible clinical signs of the aging eye , there are clinically relevant changes which can develop into pathological ophthalmological diseases.
In addition to neuro-cognitive dysfunction , it has also been associated with declining physical performance possibly due to sarcopenia.
In addition to obesity and insulin resistance , inflammation is emerging as a potential etiologic factor of the syndrome.
In addition , tools and models for recognition of end of life in frailty and considerations for symptom management are introduced.
In addition to osteoporosis-related disorders , vitamin D deficiency may influence several medical conditions conferring an increased mortality risk.
In addition to parkinsonian symptoms , older patients with PD may need to undergo surgery for several conditions.
In addition to PD , defects in mitochondrial function are associated with normal aging and with many diseases of aging.
In addition to persistent viral infection , psychological stress as well as oxidative stress can also contribute to the generation of senescent dysfunctional T lymphocytes.
In addition to population aspects , identification of potentially targetable cellular defects is receiving renewed interest.
In addition to positive and negative symptoms , cognitive deficits are increasingly being recognized as a core feature of schizophrenia.
In addition to preventive efforts , healthcare systems must emphasize training of a urologic oncology workforce.
In addition to progressive dementia , Alzheimer's disease ( AD ) is characterized by increased incidence of seizure activity.
In addition to replication errors , DNA replication fidelity and inefficient DNA repair machinery in the spermatogonia also contribute to the mutagenic load.
In addition to rs8752 and rs2612656 , HPGD tagSNPs rs9312555 , rs17360144 and rs7349744 were genotyped for haplotype analyses.
In addition to structural brain mechanisms , we demonstrated that attention modulates the direction and degree of ear asymmetry in dichotic listening.
In addition to supplying cellular energy , mitochondria are involved in signaling , cellular differentiation , cell death , and the aging process.
In addition to suppressing tumorigenesis , cellular senescence might also promote tissue repair and fuel inflammation associated with aging and cancer progression.
In addition , total leg blood flow as recorded by femoral artery Doppler-flow.
In addition to that , BDNF levels had association with level of physical activity.
In addition to the ADHD diagnosis , the associations between the number of ADHD symptoms , depressive symptoms and adverse life events were examined.
In addition to the age-related reduction in resorption , there is a negative correlation between AGEs and resorption independent of age.
In addition to the basic science and clinical discussions , there were educationally-focused talks related to practical aspects of management at home and in school.
In addition to the cartilage itself , OA also involves the surrounding tissues , including the synovium and the subchondral bone.
In addition to the copper-2 hypothesis , this review covers dietary changes that enhance the epidemic.
In addition to the CR theory , the free radical theory is another important hypothesis , which is believed to be involved in aging.
In addition to the detected diseases , particular functional shifts in neuropsychological and vegetative status of the liquidators were observed.
In addition to the deterioration of family support , the worsening of health status is another significant factor.
In addition to the detrimental effect on insulin sensitivity , pro-inflammatory cytokines also stimulate energy expenditure and facilitate adipose tissue remodeling.
In addition to the disease state , arterial stiffness increases from the proximal to the distal arterial compartments.
In addition to the effect size , power to detect associations is largely driven by sample size.
In addition to the genetic approaches , dietary supplement with Sirt1 activators , resveratrol or SRT1720 , were fed to wild type mice with OIR.
In addition to the increased risk of occurrence of cancer among older patients , they are more predisposed to poor outcomes after definitive treatment.
In addition to their antioxidant properties , soy products also have the ability to affect cognition via interaction with estrogen receptors.
In addition to their epidemiologic and clinical association , mounting recent evidence indicates shared mechanisms of pathogenesis between metabolic disorders and AD.
In addition to their structural collapses , COPD and IPF might increase the vulnerability to pathogen insults through SASP.
In addition to the licensed indications , other special populations were considered for discussion.
In addition to the original data , we searched the literature ( 2008-2016 ) for the latest publication on the described subjects.
In addition to the reduction in the volume of pulp chamber , changes to the dental pulp also include dental pulp calcifications.
In addition to the reflection characteristics , skin hydration , the melanin index , and the hemoglobin index were also measured.
In addition to the role in maintaining HSC homeostasis , the niche has also been implicated in the pathogenesis of blood disorders including hematological malignancies.
In addition to the schwannoma , six tumors were resected based on results of MRI screening , all of which were meningiomas on histologic review.
In addition to these genome-wide mutational signatures , hypermutation localized to small genomic regions , ' kataegis' , is found in many cancer types.
In addition to these objective driving measures , subjective measures of workload and driving performance were also included.
In addition to these two activities , family caregivers of patients with moderate dementia provided more assistance with mobility and protection.
In addition to the use of complementary medical procedures , integration of hyperthermia in the treatment process is a useful option.
In addition to the well-described implications of estrogen deficiency in postmenopausal osteoporosis ( PMO ) , free radicals are also effective on bone metabolism.
In addition to the widely known economic benefits associated with competition , these findings suggest that significant negative welfare externalities exist as well.
In addition to this , the electrical chart specific for the proximal femoral fracture was made which enables to eliminate in-hospital reference letters.
In addition to thousands of research papers related to resveratrol ( RSV ) , approximately @number@ review articles have been published.
In addition to traditional risk factors , lymphopenia , a surrogate indicator for immunosenescence , was a significant risk factor for LTCF-acquired infections.
In addition to translating the DJGLS for these ethnic groups , several statistical analyses were performed to assess the scale's reliability and validity.
In addition to variability in efficacy , several patients developed graft-induced dyskinesia.
In addition to vitamin D , calcium supplementation has shown to enhance the effect of vitamin D on bone.
In addition to Zn ( 2 + ) homeostasis , antioxidant role of MTs is routed through -SH moieties on cysteine residues.
In addition to αT , although to a lower amount , also γT is phosphorylated.
In addition , TQ Green can be conveniently applied in fluorescence activated cell sorting ( FACS ) to measure GSH level changes.
In addition , training based on reactivation of autobiographical memories is shown to produce a long-lasting effect on memory performance.
In addition , transgenic mice overexpressing FGF21 have an extended lifespan.
In addition , treating Hutchinson-Gilford progeria syndrome ( HGPS ) cells with the mTOR inhibitor rapamycin improves their fate.
In addition , treatment-induced premature senescence could compensate for resistance to apoptosis via alternative signaling pathways.
In addition , treatment of HEK293T cells with Rc resulted in cAMP-response element-binding protein ( CREB ) -binding protein ( CBP ) regulated FoxO1 acetylation.
In addition , treatment with protein farnesyltransferase inhibitors improves whole animal phenotypes in mouse models of HGPS.
In addition , triglycerides were negatively associated with LTL in female participants ( p < @number@ ) .
In addition , TRIM partially inhibited both 5-HT-induced contractions and cytosolic Ca ( 2 + ) levels without affecting CPA and PE responses.
In addition , trisomies have been shown to disrupt normal epigenetic marks across the genome , perhaps in response to changes in gene dosage.
In addition , TTR cleaves Aβ peptide in vitro.
In addition , TTR was positively correlated with systolic and diastolic blood pressure and postprandial triglyceride ( TG ) .
In addition , two different types of other prebiotics , galacto-oligosaccharide and bifidogenic growth stimulator , were also given.
In addition , two interaction terms - neuroticism by hopelessness and neuroticism by acculturation - were both significant predictor variables with strong explanatory power.
In addition , two maintenance treatments were conducted @number@ and @number@ months following treatment end.
In addition , two overarching themes were identified : ( @number@ ) fairness considerations and ( @number@ ) unavailability of systematic empirical evidence.
In addition , ultrasonographic femoral cartilage grading was also performed for each knee.
In addition , undesired outcomes of facelift surgery and common risks of facelift surgery are circumvented.
In addition , up to 75-80% of deaths in diabetic patients are associated with major cardiovascular events including stroke.
In addition , up to now the tools used to measure hydration are controversial.
In addition , UR-13756 is an effective p38 inhibitor at @number@ μm in Werner syndrome cells , as shown by immunoblot.
In addition , users can cluster and group brains according in multiple ways for subsequent comparison using graphical data mining tools.
In addition , using both P / M and T / M blocked the increase of cell media temperature induced by IR lamp.
In addition , using next-generation sequencing ( NGS ) , we identified several variant genes.
In addition , using Western blot , we investigated whether the inhibition was due to the interference on activation of NF-κB.
In addition , valproic acid worked synergistically with Mg132 in elevating ubiquitin load and causing cell death.
In addition , vasorelaxation experiments were performed using 10-week- and 24-month-old thoracic aortic ring segments in organ chamber baths.
In addition , VBM revealed significant hippocampal volume reduction bilaterally in all postmenopausal women compared with all premenopausal women.
In addition , vertebral instability may be the predominant cause of delayed neurologic deficit.
In addition , vessels exhibited prominent adventitial fibrosis , a previously undescribed feature of HGPS.
In addition , vitamin D has recently been proposed to play a role in the pathophysiology of many chronic diseases.
In addition , we address the role of TET proteins in gliomas.
In addition , we aimed to associate presence of these SNPs to development of BC along @number@ years period.
In addition , we also examined age-related differences in such dual-task effects.
In addition , we also test the association between loss of cognition ( exposure ) and tooth loss ( outcome ) .
In addition , we analyzed CRC samples ( n = @number@ ) from patients recruited in a clinical setting ( DACHSplus study ) .
In addition , we analyzed heart rate data in children undergoing sevoflurane inductions , looking for age-related differences.
In addition , we assessed perceived participation restrictions.
In addition we assessed quality of life ( QoL ) and appetite.
In addition , we assume that maybe other oxidation reactions also have induced effects , such as corrosion , aging and passivation.
In addition , we calculated the frequency spectrum of trunk sway using the marker locus from @number@ to @number@ Hz by fast Fourier transform.
In addition , we comment on the regulatory role that lipid molecules and their modifying enzymes play on different steps of the autophagic process.
In addition , we compared the expression levels with the local load of tau and amyloid-beta deposits , evaluated using morphometry.
In addition , we conducted three focus groups and four interviews.
In addition , we confirmed the previously reported association between the APOE ε4 allele and earlier disease onset.
In addition , we consider related mechanisms in other organisms and discuss their similarities and idiosyncratic features in a comparative manner.
In addition , we could discriminate changes in gene expression due to quiescence during cellular senescence from those that were specific to senescence.
In addition , we demonstrated age-related significantly increased WT TTR deposits , but not variant TTR deposits , in cardiac tissues of male patients.
In addition , we demonstrated that overexpression of Ndfip1 caused DMT1 + IRE downregulation , resulting in the decreased iron influx and iron-induced neurotoxicity.
In addition , we demonstrate that mild chronic stress during aging promotes mislocalization of nuclear RBPs.
In addition , we demonstrate that part of this regulation occurs at the level of DNA binding.
In addition , we detected that two NHEJ genes ( LIG4 and XRCC6 ) presented age-dependent promoter methylation changes.
In addition , we determined mechanical properties and microstructure of the patellar tendon.
In addition , we determined the optimal temperature conditions for enhancing the production of soluble hLA.
In addition , we discuss how changes in the cellular microenvironment can modulate peroxisome biogenesis and function.
In addition , we discuss possible application of these information in regeneration of bone and cartilage.
In addition , we discuss several new applications of proteomic analysis to the investigation of mitochondrial activity.
In addition , we discuss specific techniques that we use that have helped us achieve more natural and lasting results.
In addition , we discuss the evidence tying sphingosine kinase-mediated stress responses to the process of aging.
In addition , we discuss the possible role of muscle load in aging and propose new directions for future studies of the musculoskeletal system.
In addition , we discuss the role of rheumatoid arthritis synovial fibroblasts in autoimmunity.
In addition , we evaluated differences based on age and gender.
In addition , we evaluated the association between clinical variables and poor functioning in the patient group.
In addition , we evaluated the clinical course between CMV-DNA- cases and CMV-DNA + cases with low viral load.
In addition , we examined age-related differences in the observed associations among mindfulness , stress , and controlled regulatory behavior.
In addition we examined DNA methylation at the APP gene itself , to see whether there were changes in DNA methylation in this population.
In addition , we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups.
In addition , we examined how coping strategies are utilized by African-American elders who choose not to seek professional mental health services.
In addition , we examined metacognitive processes associated with each VSWM component.
In addition , we examined self-management abilities ( SMAs ) as determinants of loneliness among the visually impaired elderly.
In addition , we examined the extent to which ABPV was predicted by demographics , cardiovascular risk factors , and medication.
In addition , we examined the reliability and factorial structures of the Dutch BRIEF.
In addition , we explored the relationship between the identified cognitive subtypes , and their demographical and neurobiological characteristics.
In addition , we explored whether the effect of attentional focus on motor learning was influenced by children's age and verbal working memory capacity.
In addition , we find evidence for an association between relative cognitive impairment and psychosis.
In addition , we find that γ-secretase / Notch modulation may be a candidate drug target in SNX27-associated hydrocephalus such as that observed in DS.
In addition , we found that cyclin K is highly expressed in human testicular cancers.
In addition , we found that DAF-18 / PTEN inhibits regeneration independently of age and FOXO signaling via the TOR pathway.
In addition , we found that early AD is distinct from late AD with respect to the inflammatory profiles expressed in the brain.
In addition , we found that Exo70 is alternatively spliced in a cell-type- and cell-age- dependent way.
In addition , we found that externally administered uric acid aided termite survival under highly oxidative conditions.
In addition , we found that logical reasoning predicted individual differences and age-related differences in sadness and anger recognition but not in happiness recognition.
In addition , we found that pan-O-GlcNAcylation was remarkably stronger with lower OGA expression in aged retina.
In addition , we found that the circadian rhythm-related gene PER2 decreased as consequence of menopause.
In addition , we found that the functions of LRP5 in arthritic cartilage were subject to transcriptional activation by β-catenin.
In addition , we have also provided a comprehensive summary for the top ranked genes in AlzBase.
In addition , we have examined whether prodromal dementia affects the study outcome.
In addition , we have identified a number of tools which could be applied in community-based intervention studies designed to enhance healthy ageing.
In addition , we have identified non-coding RNA genes and differentially expressed transcript isoforms of known matrix components with ageing which require further investigation.
In addition , we have started to include new ageing-related information.
In addition , we highlight epigenetic approaches for stroke therapy , including the inhibition of DNA methyltransferase and histone deacetylase enzyme activities.
In addition , we hypothesized increased difficulties in emotion regulation and lower cognitive control to mediate this relationship.
In addition , we identified an effect of blood contamination on the CSF levels of miR-16 , miR-24 , and miR-146a.
In addition , we identified changes in various enzymes , as well as the mechanisms behind the PYP1-5-induced collagen synthesis.
In addition , we identified @number@ families with unclassified focal childhood epilepsies carrying predicted truncating DEPDC5 mutations ( @number@ of @number@ ) .
In addition , we identified @number@ genes differentially expressed across time points that we linked with aging within and across studies.
In addition , we identified @number@ SUMOylation sites in target proteins , of which @number@ are located in the proximity of phosphorylated residues.
In addition , we identify gene gain and loss involving genes associated with DNA repair , cell-cycle regulation , cancer , and aging.
In addition , weight changes , oral health , constipation , obesity , implementing nutritional care are highlighted.
In addition , weight gain in midlife contributes to other health risks including cancer , arthritis , mood disorders , and sexual dysfunction.
In addition , we implement models that allow for age-specific TTD effects on LTC utilization as well as sex-specific effects.
In addition , we included interactions with sex to investigate the difference between men and women.
In addition , we interpreted the reassessment radiographs of @number@ of the patients.
In addition we investigated age-related changes in the ability to categorize faces at basic , subordinate , and individual levels.
In addition , we investigated differences between the anterior , middle , and posterior parts of both structures.
In addition , we investigated the associations between certain gait parameters and a history of falls in study participants.
In addition , we investigated the presence or absence of PIMs for patients transferred to our hospital with ADEs and unexpected illnesses.
In addition , we investigated the roles of these genes in the well-studied α-synuclein-induced Drosophila model of Parkinson's disease.
In addition , we investigated whether deficits in semantic clustering were related to progression from healthy aging to aMCI and from aMCI to AD.
In addition , we investigated whether S-ASC osteogenic commitment was enhanced by adenosine A1 receptor ( A1R ) stimulation , as previously shown for DPSCs.
In addition , we measured endothelium-dependent and endothelium-independent vasodilation in @number@ healthy subjects divided into four age groups.
In addition , we noticed an age as well as hearing sensitivity related effect on the listening effort.
In addition , we observe a senescence-specific spatial clustering of heterochromatic regions , suggesting a unique second step required for SAHF formation.
In addition , we observed a clear female-specific risk trend for the effect of rs6265 on AD endophenotypes.
In addition , we observed age-related decline in functional connectivity in @number@ visual and @number@ motor / visuospatial networks.
In addition , we observed a novel association between this locus and serum levels of IGF-1 in women ( P = 0.005 ) .
In addition , we observed changes in fecal microbiota composition along with age.
In addition , we observed greater choice stepping reaction time dual-task costs above the breakpoint of @number@ CGG repeats relative to below this CGG range.
In addition , we obtained data on adherence of the participants to the exercise program.
In addition we performed a systematic review of the literature on the subject based on PubMed , Medline and Google Scholar searches till year-end @number@
In addition , we performed stratified analyses by region : urban or rural.
In addition , we point out the importance of reducing cardiovascular risk factors.
In addition , we predict several phenomena related to aging and differentiation based on this model.
In addition , we provide insight into whether and how state policies directed at guiding research practices can shape output.
In addition , we quantified the relationships between age and a variety of cognitive assessments and found relationships between regional cerebellar volumes and performance.
In addition , we re-analyzed longitudinal LTL data collected from four study populations to test the hypothesis that LTL attrition depends on baseline LTL.
In addition , we recommend a set of technical and empirical readings for each technique.
In addition , we report on AMH levels in women according to BMI , smoking status and reproductive history.
In addition , we reviewed the comorbidities between the two groups as well as complication rates between less than @number@ and more than @number@ group.
In addition , we review how mutant DNMT3A may contribute to leukemogenesis and the clinical relevance of DNMT3A mutations in hematologic cancers.
In addition , we review the biological properties of peroxisome-derived signaling messengers and discuss how these molecules may mediate various biological responses.
In addition , we showed evidence of HDAC / PI3K dual inhibition accompanying antitumor efficacy in xenograft tumor tissues by immunohistochemistry.
In addition , we showed that truncation is associated with increased resistance to drug-induced apoptosis and is indicative of increased patient chemoresistance.
In addition , we show reproducibility complications of accelerated aging tests by the use of different autoclaves and possible implications for standardized procedures.
In addition , we show that Abeta inhibits the angiogenesis stimulated by glioma cells when cocultured with human brain microvascular cells on a Matrigel layer.
In addition , we show that both deferiprone and the derivatives modulate several distinct signaling pathways associated with neuroprotection.
In addition , we show that corpus word frequency and prevalence are complementary measures of word occurrence covering a broad range of language experiences.
In addition , we show that manipulation of SIRT1 levels by either over-expression or siRNA-mediated knockdown resulted in delayed and accelerated cellular senescence , respectively.
In addition , we show that MS patients generate function-blocking anti-Gal-8 antibodies with pathogenic potential.
In addition , we show that the DNA damage response in HGPS cells does not originate from eroded telomeres.
In addition , we show that the level of instability is highly heritable , implying a role for individual-specific trans-acting genetic modifiers.
In addition , we show that these genes synergize topologically with disease and longevity genes , forming unexpectedly large network communities.
In addition , we studied persons with other musculoskeletal pain than fibromyalgia and persons who did not have any musculoskeletal pain.
In addition , we suggest that CANTAB may be useful to detect subtle cognitive changes in healthy aging.
In addition , we suggest that chronic eHSP72 exposure may mediate β-cell failure.
In addition we used an aging model and Lon protease deficient HeLa cells to investigate the influence of mitochondrial degradation processes on lipofuscin formation.
In addition , we used neuropsychological tests to study executive functions and cognitive control , sustained by the prefrontal cortex.
In addition , we used tract-based spatial statistics for voxel-wise analysis of the DTI-derived parameter fractional anisotropy in the white matter tracts.
In addition , we validated differential methylation of NOD2 / CARD15 by bisulfite sequencing in DS versus control T-cells.
In addition , we validated that purified MI061 significantly interferes ligand binding to EGFR and blocks EGFR's phosphorylation.
In addition , we were interested in determining potential molecular mechanisms responsible for altering post-training muscle protein turnover.
In addition , we will discuss the complexity of ACh actions in memory function to better understand the physiological role of ACh in memory.
In addition , wheat germ agglutinin-staining indicated that the average size of cardiomyocytes increased with age.
In addition , whereas CHIP silencing has no effect on p53 stability in young cells , a considerable p53 accumulation occurs in their senescent counterparts.
In addition , whether causal ALS mutations represent gain or loss-of-function alleles remains unknown.
In addition , while MMSE scores did not change over the 4-year period , NINL scores did.
In addition , while not approved for this indication , armodafinil has been found to improve excessive sleepiness associated with jet-lag disorder.
In addition , within the overall anabolic or catabolic effects , the feeding and metabolic actions of certain peptides may not change simultaneously.
In addition , women completed a visual tracking task during which heart rate variability and attentional capacity were assessed.
In addition , women from low childhood SES backgrounds took longer to fall asleep than women from high SES backgrounds.
In addition , women with hyperandrogenism have higher risk for cardiovascular disease and insulin resistance.
In addition , Yes-associated protein has been shown to regulate cardiomyocyte fate through multiple transcriptional mechanisms.
In addition , young adult ApoE2 female mice showed improved hippocampal progenitor cell proliferation.
In addition , younger adults were more likely to underestimate the distance between semantically related landmarks than were older adults.
In addition , Z-FY ( t-Bu ) - DMK modulated the Bcl-2 family levels , and suppressed caspase-3 activation.
In AD donors , astrocytes near plaques displayed increased staining of both GFAPα and GFAPδ.
Inadequate and restless sleep , along with pain , is often a driving symptom for patients to proceed with rotator cuff repair.
Inadequate nutritional intakes and physical activity , together with endocrine disturbances are associated with of sarcopenia and frailty.
Inadequate pancreatic β cell function underlies type @number@ and type @number@ diabetes mellitus.
Inadequate vitamin D status is highly prevalent in the Korean population , especially among young adults.
Inadequate work break and sleep , family care-giving responsibility and aging may challenge work recovery.
In a dialogue task , young and older adults described transitive verb target pictures after hearing active or passive sentences.
In AD , in addition to brain , a number of peripheral tissues and cells are affected , including erythrocytes.
In adipose-derived human MSCs , MSDK induced osteoblastogenesis.
In a direct kinase assay , CA was revealed to directly inhibit IRAK1 and IRAK4.
In a discriminant analysis with ROIs having effect size larger than @number@ both pipelines yielded no significant differences in the AUC.
In adjusted analyses , the largest LHDs were @number@ times more likely to have a succession plan than the smallest.
In adjusted Bayesian-Weibull modeling , point estimates indicate ICD efficacy persists but is attenuated with increasing age.
In adjusted models , LDCW performance variables were associated mainly with mortality.
In adjusted models , ND was not associated with hypertension awareness or treatment.
In adjusted models , physical and cognitive capacity measures were most important in predicting accommodations and accommodations most important in predicting unmet need.
In adjusted models , the association between MeDi adherence and MRI infarcts remained essentially unchanged.
In adjusted multi-level analyses , greater memory decline and lower general perceived control were associated with more everyday memory problems.
In ADNI-GO / 2 participants , white matter integrity provided independent information about current executive function , but was not sensitive to future cognitive change.
In adolescent group , Cobb angle in left was @number@ in neutral was @number@ and in right was @number@
In adolescents , a traffic accident as an unbelted rear seat passenger was the most frequent etiology.
In a double-blind , placebo-controlled within-subject design , subjects were measured after levodopa ( @number@ mg ) or placebo administration.
In AD patients , the brain regions with hypometabolism can trigger overexpression of amyloid precursor protein and decrease the clearance of Aβ.
In AD patients , β-amyloid peptide ( Aβ ) plaques and neurofibrillary tangles are common features observed in the CNS.
In AD , semantic memory processes are preserved longer than processes related to episodic memory.
In AD , significant receptor losses were registered in entorhinal cortex and lacunosum moleculare ( @percent@ and @percent@ , respectively ) .
In AD , the UPR was extensively activated in the hippocampus.
In AD , this protective program may be overridden by genetic and other risk factors , or its maintenance may become dysregulated during aging.
In adult group , Cobb angle in left was @number@ in neutral was @number@ and in right was @number@
In adult males , it is induced by endogenous testosterone decline through aging and other modifiable factors.
In adult men the lower limit for the normal reference range is around @number@ nmol / L , but this figure can vary among laboratories.
In adult organisms , age-dependent loss-of-function of tissue-specific stem cells is causally related with a decline in regenerative potential.
In adults < 55 years @percent@ of deaths were due to infections whereas in adults ≥55 years @percent@ of deaths were due to NCDs.
In adults , but not adolescents , not only sleeping less but also sleeping more than one's average can be associated with lower affective well-being.
In adults , dehydroepiandrosterone ( DHEA ) is the most abundant steroid found in serum and its levels fall with age.
In adults , EEG after SD is usually performed in the morning after SD.
In adults , exposed birds had higher vanadium , and , following the final exposure , higher bicarbonate.
In adults , HSCs reside in marrow cavity of long bones where they self-renew and differentiate to replenish short-lived mature blood cells.
In adults , it had long been considered to be absent or at least of no relevance.
In adults , it is notable that an age of onset ≥ @number@ years is associated with the worst control.
In adults , jaw muscles also differ markedly from limb and trunk muscles in composition and distribution of fibre types.
In adults , the dose was normalized ( TI , toxic Index ) by dividing the supposed ingested dose by the maximal recommended dose.
In adults , the greatest TIs in nordiazepam and oxazepam overdoses were @number@ and @number@ respectively.
In adults , there was either no relationship with age , or a slow reduction in thickness in older age.
In adults , the values were @number@ ± @number@ and @number@ ± @number@ μm , respectively.
In adults , valvular operations were the most common type of surgical operations , increasing from @percent@ to @percent@ of all procedures over time.
In adults , while females statistically significantly preferred water , males chose cups with coloured contents ( p < 0.01 ) .
In adult teeth , this condition is described as an ' old odontoblast ' stage.
In adult testes , cyclin K can be detected in spermatogonial stem cells but is absent in differentiating spermatogonia , spermatids and spermatozoa.
In adult , the early return ( during systole ) of the reflected pressure wave means disadvantage to cardiac blood supply-workload balance.
In adult tissues , MuSCs are retained in a quiescent state until they are primed to regenerate damaged muscle through cycles of self-renewal divisions.
In advanced age , physical activity is also effective at mitigating sarcopenia , restoring robustness , and preventing / delaying the development of disability.
In advanced age this multisensory activation was most prominent during standing , less during walking , and least during running.
In advanced phases , the clinical hallmark of the disease is a striking inflammatory syndrome.
In advanced-stage OA , the concentration-dependent frictional response of articular cartilage was observed with γ-globulin , but not with HA.
In a few cases the decision ( @percent@ ) or even action ( @percent@ ) was taken to make alterations.
In a first step , we extracted a set of eight representative meta-measures from the data.
In age- and gender-adjusted linear regression analyses , we did not find association of rs13043313 with any of the traits.
In age- and sex-stratified analyses , no significant associations between anemia or hemoglobin levels and falls could be found.
In aged adult valves , there was proteoglycan infiltration of the annulus hinge , consistent with the observed mechanical differences over time.
In aged arteries , SIRT1 expression and activity is blunted , which contributes to the development of atherosclerosis and abnormal vascular responses.
In aged bone , osteocyte lacunae showed an increased amount of hypermineralized calcium phosphate occlusions in comparison with younger cases.
In AGEd cultures , polarity of secretion was impaired despite maintenance of physiological barrier properties of the monolayer.
In aged HDPCs , autophagy and intercellular adhesion molecule @number@ and vascular cell adhesion molecule @number@ were increased , while PPARγ and HO-1 were decreased.
In aged human skin , wound healing rates decrease and cellular damage by reactive oxygen species ( ROS ) accumulates.
In aged human , the number of muscle fibers and motor units decreases.
In aged individuals , senescence is found in cells that have exhausted their replication potential.
In aged iPSCs we have also found an altered expression of genes relevant to mitochondria biogenesis.
In aged mice , accumulation of RanGAP1 together with polyglutamine is shifted to perinuclear and cytoplasmic areas.
In aged mice , prevention of ectopic beats as well as echocardiographic amelioration was also demonstrated with improved exercise performance.
In aged mice , topical HOCl attenuated age-dependent production of p16INK4a and expression of the DNA repair gene Rad50.
In aged mice , we assessed how intensive exercise affects brain bioenergetics , inflammation , and neurogenesis-relevant parameters.
In aged rats , there was no difference between conditions in the level of falsely recalled Set @number@ items ( intrusions ) .
In aged skin there are fewer LC and migration is impaired compared with young skin.
In aged tissues , increased but also decreased expression of autophagy-specific proteins , Beclin @number@ LC3 , Atg5 and Atg7 has been reported.
In age groups 75-79 and 85-89 years , however , race times were similar for both women and men.
In ageing , microglia coverage is reduced leading to enlarged protofibrillar Aβ42 hotspots and more severe neuritic dystrophy.
In ageing populations many patients have multiple diseases characterised by acceleration of the normal ageing process.
In a genetic screen , we identified TRIM25 as a novel regulator of p53 and Mdm2.
In a genome-wide association study of @number@ adults , we discovered five previously unknown loci for intracranial volume and confirmed two known signals.
In age @number@ to @number@ @percent@ showed a smaller I / 4 isopter area than that of the grade @number@ criteria.
In age @number@ to @number@ @percent@ showed a smaller I / 4 isopter area than that of the grade @number@ criteria.
In age-related muscle atrophy , a decrease in muscle fiber size and number , and a preferential loss of type II fibers have been reported.
In aggregate , our results suggested that miR-33b-3p modulated the cisplatin sensitivity of cancer cells might probably through impairing the DNA damage response.
In aggregate , our study reveals that palmitoylation of gephyrin by DHHC-12 contributes to dynamic and functional modulation of GABAergic synapses.
In aging cells , the DNA binding activity of HSF1 deteriorates correlating with the onset of pathological events including neurodegeneration and heart disease.
In aging fibroblasts , pro-inflammatory conditioning aggravates the shortening of telomeres , an effect which was only in part driven by increased cell turnover.
In aging , immune responses are dramatically impaired , specifically the ability to produce protective antibodies.
In aging , microglia tend to transition to the M1 pro-inflammatory state and become hypersensitive to messages emerging from immune-to-brain signaling pathways.
In aging populations , hypoglycemia has the potential for catastrophic consequences.
In aging societies increasing cases of neurodegenerative protein deposit diseases urge for the identification of the underlying mechanisms.
In agreement , EAA supplements in healthy older adults are more effective than supplements with the composition of complete proteins.
In agreement , they featured severe naïve CD4 T-cell depletion and contraction of T-cell receptor diversity.
In agreement with demographic evidence , almost all SSHs coalesce in the post-Nuragic , Nuragic and Neolithic-Copper Age periods.
In agreement with previous literature , we observed an FA increase with age , which was mainly due to the decrease of perpendicular diffusivity.
In agreement with these results , VO ( 2max ) and mtOD were positively correlated ( P = 0.01 ) .
In a group of @number@ healthy subjects , the repeated distensibility measurements demonstrated a significant correlation ( R = @number@ p = @number@ ) .
In a humanized mouse model of pseudoxanthoma elasticum , we investigated whether 4-PBA treatments could rescue the calcification inhibition potential of selected ABCC6 mutants.
In a large population-based cohort study , F2RL3 methylation was measured in baseline blood samples of @number@ participants by MassARRAY.
In a list-method directed forgetting paradigm , subjects have to learn two word lists.
In all , 86 / 225 ( @percent@ ) had any history of AF.
In all age groups an increase in surface rotation and lateral deviation of the spine with increasing LLIs was found.
In all age groups , except 6-10 years old , females had significantly higher UBT results than males.
In all age groups , FeNO levels were positively associated with eosinophil counts , and with testing in the morning.
In all age groups in both women and men , absolute 10-year risk of IHD and MI increased with increasing number of visible age-related signs.
In all age groups , mild hearing loss was the most common form of hearing loss.
In all ages , the leaning forward posture was more frequent than sitting.
In all analysed series , the neonatal line width was diversified depending on the child's age at death.
In all analyses , the cytotoxicity was significantly higher after LED irradiation compared with cytotoxicity after QTH irradiation.
In all analyses , we used antibody threshold levels shown to correlate with presence of moderate-severe periodontitis.
In all analyzed CC fragments , a @number@ kDa band , Tie1 , was detected.
In all ARAF isolates the cyp51A gene was sequenced and the genotype was determined by microsatellite typing using nine short tandem repeats.
In all but one sensitivity analysis , the association between leukocyte telomere length and age at menopause became stronger.
In all care settings for older and oldest old patients , a gap exists between best-practice recommendations and current clinical practice.
In all cases , IgG binding was quenched by absorption with liver powder or lysates from non-transfected cells.
In all cases , improvement was seen in soft-tissue sagging of the midface and lower face.
In all cases , local resection was performed without a pancreaticoduodenectomy.
In all cases , miR-200c was higher versus control and its targets , that is , SIRT1 , eNOS , and FOXO1 , were downmodulated.
In all cases , secondary causes of MN , including infections , autoimmune diseases , and others , were ruled out.
In all cases , specimens for histological and immunohistochemical analyses were removed from the IVD space.
In all cases , the 3D images proved that arteriosclerotic changes in large proximal interlobular arteries did not directly induce distal arterial change or glomerulosclerosis.
In all cases , the disease was at an advanced clinical stage ( III / IV ) .
In all cases , ultrasonographic analysis of the hyoid bone was confirmed to have a similar trajectory , as determined with videofluoroscopy.
In all cases , UV photographic images demonstrated facial mottled depigmentation.
In all , clinical routine laboratory parameters and lymphocyte telomere length as T / S ratio were measured.
In all countries , health status is significantly associated with socio-demographic variables.
In all countries , multimorbidity increased significantly with age.
In all disorders , depression improved and manic symptoms remained low across the @number@ years.
In all examined groups , physical activity resulted in decrease of these oxidative stress markers and simultaneously caused adaptive increase in the erythrocyte SOD activity.
In all four scenarios , the proportion of respondents willing to perform BLS was lowest in the elderly group.
In all FP / CIT , SPECT was performed in the acute phase.
In all groups , comfort depended far more on the risk-benefit profile associated with the research scenario than with type of proxy.
In all groups , eLBM / weight correlated inversely with weight.
In all groups : no edema and thickness changes at ultrasounds in muscle and subcutis.
In all LCs , a majority of fibres had preferential orientation horizontally across the nasal-temporal axis.
In all measures , essential tremor cases demonstrated significant reductions in dendritic complexity compared with controls.
In all nine horizontal lines , CT showed a rough trend of being thickest at a particular point and decreasing thereafter.
In all , @number@ articles were identified and @number@ met the inclusion criteria.
In all , @number@ CHW were evaluated.
In all , @number@ clinical trials consisting of @number@ participants were included in the analysis.
In all , @number@ CpGs in the top @number@ genes most significantly associated with BMD were analyzed.
In all , @number@ data points corresponding to @number@ different runners over @number@ race editions ( 1999-2011 ) were retrieved.
In all , @number@ of @number@ patients aged @number@ and above , from @number@ different Saxon general practices took part.
In all , @number@ participants ( @percent@ ) were included in this multicenter prospective investigation.
In all , @number@ ( @percent@ ) patients experienced permanent CIA.
In all , @number@ ( @percent@ ) pregnancies were terminated.
In all , @number@ women were premenopausal , and @number@ postmenopausal , at the time of mammography.
In all other variables , no statistically significant differences were found.
In all participants , adverse reactions improved.
In all patients , and in @number@ age-matched healthy controls , four FOXP2 polymorphisms were evaluated , namely rs2396753 , rs1456031 , rs17137124 and rs1852469.
In all patients , modifiable risk factors for recurrent falls were assessed.
In all patients with primary osteolysis , a potential for pathologic fracture must be considered and careful intraoperative positioning is warranted.
In all , @percent@ of participants demonstrated screening skill proficiency at their first onsite screening.
In all , @percent@ reported current smoker status and @percent@ were classified as heavy alcohol drinkers.
In all , @percent@ scored below the MoCA cutoff and @percent@ scored below the IHDS cutoff.
In all racial / ethnic groups , most men did not regularly engage in basic , antiaging preventive behaviors , such as use of sunscreen.
In all specimens , we could sharply locate the PFO / D4-GFP signal to BrM.
In all strains of generated MDTG ; neu mice , tumor development was significantly delayed with decreased tumor weight.
In all studies , higher cardiovascular disease risk scores were associated with cognitive changes or risk of dementia.
In all subjects 60-minute dynamic ( R ) - [ ( @number@ ) C ] PK11195 scans were acquired.
In all subjects , age , HOMA-IR , LTL , and SBP predicted @percent@ of the variance in c-f PWV.
In all subjects , an association emerged between Schadenfreude and the ventral striatum , and between envy and the anterior cingulate cortex.
In all subjects anthropometrical measurements , 24-hr blood pressure monitoring , echocardiographic examination , and carotid ultrasound were performed.
In all subjects , AS performance correlated with neuropsychological measures of executive function , even after controlling for disease severity.
In all subjects , body composition was assessed by bioimpedance analysis , and ALM index was calculated.
In all subjects , high-frequency ultrasound ( @number@ MHz ) was performed to evaluate SLEB echogenicity changes during treatment.
In all subjects , HOMA-IR , age , sex , and SBP predicted @percent@ of the variance in LTL.
In all the cases , EndoPAT assessments were done at pre- and post-BR immobilization as well as following @number@ days of ambulatory recovery.
In all the @number@ groups , the multivariate-adjusted eGFRs in men were lower than the corresponding eGFRs in women.
In all the studies , there was a highly significantly improved net reclassification index ( P < 10 ( @number@ ) ) .
In all three experiments , H.M. detected reliably fewer errors than carefully matched memory-normal controls.
In all three parts of the fornix , the FA value and tract number decreased , whereas ADC value increased with aging.
In all three patients , speech discrimination ability and vestibular function markedly declined with aging.
In all three subgroups , there was a reduction in the number of PC with advancing age.
In all vertebrates , they are composed of TTAGGG repeats coated with specific protecting proteins.
In a longer-term driving simulator study , the effects of an intersection assistant on driving were evaluated.
In a longitudinal analysis , better physical function was significantly associated with survival advantage until the age of @number@
In a longitudinal study , participants trained with this belt for seven weeks in natural environment.
In ALS , an alteration of large-scale functional brain networks associated with cognition does occur , even in the absence of overt dementia.
In Alzheimer's brain , we found an increased cellular expression of CREM in dentate gyrus neurons as compared to controls.
In Alzheimer's disease ( AD ) , amyloid-β ( Aβ ) pathology and intrinsic functional connectivity ( iFC ) interact.
In Alzheimer's disease ( AD ) cerebrovascular function is at risk.
In Alzheimer's disease ( AD ) -like APPPS1 mice Aβ-deposition is paralleled by iP upregulation , most likely mediated through type I interferon induction.
In Alzheimer's disease ( AD ) , lipid alterations are present early during disease progression.
In Alzheimer's disease ( AD ) misfolded tau accumulates intraneuronally and leads to axonal degeneration.
In Alzheimer's disease ( AD ) patients , depression is not rare.
In Alzheimer's disease ( AD ) , persistent microglial activation as sign of chronic neuroinflammation contributes to disease progression.
In Alzheimer's disease ( AD ) , the cerebral pathological changes begin many years before the clinical manifestation of the disease.
In Alzheimer's disease , autobiographical memory deficit , characterized by a Ribot's temporal gradient , is connected to different regions according to memory remoteness.
In Alzheimer's disease , this protein is responsive to amyloid-β and proinflammatory cytokines in astrocytes.
In a magnetic resonance imaging substudy of @number@ participants , structural brain volumes , cerebral microbleeds , infarcts , and white matter hyperintensities were measured.
In AMC , we found increased CTh and volume in temporoparietal regions and in precuneus-posterior cingulate compared with controls at baseline.
In AMD , imbalances in the M1 and M2 populations together with activation of retinal microglia are observed and potentially contribute to tissue degeneration.
In AMD , many of these changes are exacerbated in addition to the development of disease-specific factors such as soft macular drusen.
In AMD , polymorphisms in CFH , CFB and C2 were similarly implicated.
In AMD , we identified a graded activation of pathways related to wound response , complement cascade , and cell survival.
In a mechanistic proof-of-concept intervention over @number@ months , we investigated whether healthy older adults ( 60-77 years ) also show such plasticity.
In a mediation analysis , controlling for amyloid pathology strongly attenuated the effect of the CR1 locus on cognitive decline.
In a memetic fashion , MS-CAP combines two components with complementary algorithm logics.
In American society , the sexually desirable woman is young and thin.
In AMI-induced mice , prior proton irradiation improved cardiac function restoration and enhanced cardiac remodeling.
In a model including only endocrine factors , hot flush severity was significantly associated with higher FSH and lower estrone levels.
In a mouse model , GO-Y078 presented @number@ fold more survival elongation that was not achieved by curcumin and GO-Y030.
In a mouse with thickened BM ( ApoEnull ) , the effect of laser treatment was quantified using electron microscopy and quantitative PCR.
In a multiple regression analysis , adiponectin ( p = @number@ ) and VFA ( p = @number@ ) were significant predictors of PTX-3 levels.
In a multivariable analysis , the associations between T , E1 , and calculated free T and self-rated health remained statistically significant.
In a multivariable model for health status , having @number@ or more chronic conditions was more strongly associated with poorer health status than cancer survivorship.
In a multivariable model the mean CAC score did also not differ between the GFR tertiles.
In a multivariate analysis , AG proved to be an independent factor.
In a multivariate analysis , the LVESV was found to be an independent factor of the myocardial TG content.
In a multivariate linear regression model , age and plaque score remained independently associated with the increased rate of reduced salivary flow.
In a multivariate logistic regression analyses and after performing a backward regression analysis , only age and education were significant determinants of the MetS.
In a multivariate model , poor appetite and reporting difficulties walking stairs ( participants aged < @number@ years ) remained early determinants.
In amyloid positive subjects with normal cognition , slowing of oscillatory brain activity is related to clinical progression.
In amyotrophic lateral sclerosis ( ALS ) , objective biomarkers are needed for early diagnosis and progression monitoring.
In an adjusted model , age ≥ @number@ years ( N = @number@ ) was associated with increased PGE-M ( P = @number@ ) .
In an age-heterogeneous ( 18-82 years ) sample of @number@ adults , we found no factorial dedifferentiation between face cognition and general cognition.
In an aging population , however , increasing numbers of patients have comorbidities that make surgical intervention a high-risk procedure.
In an aging population in western countries they present an important cause of morbidity and mortality.
In an aging society , research involving neurodegenerative disorders is of paramount importance.
In an aging society , social demands for home-based rehabilitation and assistive technologies by healthcare and welfare services are globally increasing.
In an aging society , the incidence of brain ischemia increases dramatically.
In an aging society , the number of people with dementia has increased.
In an aging society this way of patient selection seems to be questionable.
In an aging world , maintaining good health and independence for as long as possible is essential.
In analogy , sAPPα was able to inhibit MG132-induced BAG3 expression in primary hippocampal neurons.
In an alternative estimation , cancer incidences have been analyzed by age-period-cohort ( APC ) models , allowing future prediction of cancer incidences in @number@
In analyses adjusted for baseline age and other potential confounders , this difference remained robust.
In analyses of AKI and related outcomes , results were mostly consistent between the previously published and the MDCR replication analyses.
In analyses of cognitive ability , the three CAMB cohorts can be combined provided the relevant demographic variables are included as covariates.
In analyses of monozygotic twin-pairs , heavy drinking shortened time to stroke by @number@ years ( P = 0.04 ) .
In analyses stratified by APOE genotype , our results were only significant in the group without the ε4 allele.
In analysis the data were stratified by sex , age , educational attainment , household income , language preference and previous exposure to dementia.
In an apoptosis assay , ASC converted necrotic or late apoptotic cells to early apoptotic cells.
In an attempt to describe the nature of ageing in diverse organisms , the intimate links between the origins of life and ageing are examined.
In an autochthonous lung adenocarcinoma model driven by activated oncogenic Kras and p53 loss , TrkB deficiency significantly reduced metastasis.
In androgen-dependent cancer , loss of RUNX1 impairs AR-dependent transcription and cell growth.
In an effort to bridge this knowledge gap , a systematic review of peer-reviewed journal articles was conducted.
In an era of ever-increasing healthcare costs , new treatments must not only improve outcomes and quality of care but also be cost-effective.
In an era of increasing use of supplements to better life , the benefits of DHEA in the aging female population are controversial.
In a network analysis of the candidate genes , lipid and cholesterol metabolism was a common theme.
In a new report in Nature , Ho et al.
In an execution condition , participants were forced to repeat the same strategy or to switch to another strategy.
In an exploratory study , we measured @number@ cytokines and chemokines by multiplex analysis.
In an fMRI experiment , white noise selectively enhances stimulus-driven phasic activity in the SN / VTA and auditory cortex.
In animal models , catalase deficient tissues show much slower rates of removal of extracellular hydrogen peroxide.
In animal models , dopamine depletion induces compensatory overactivation of the local renin-angiotensin system , which primes microglial responses and neuron vulnerability by activating NADPH-oxidase.
In animal models of the AD reactive astrogliosis develops in some ( e.g. in the hippocampus ) but not in all regions of the brain.
In animal models , single-gene mutations in genes involved in insulin / IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent.
In animal models , telomere dysfunction causes alveolar epithelial stem cell senescence , which is sufficient to drive lung remodeling and recruit inflammation.
In animals and humans , RAAS intrinsic to tissues modulates food intake , metabolic rate , adiposity , insulin sensitivity , and insulin secretion.
In animals , estrogenic regulation of cerebral glucose metabolism ( CMRglc ) falters during perimenopause.
In animals , klotho overexpression extends life span , and defective klotho results in rapid aging and early death.
In animal studies , bone adaptation has been initiated successfully without the transient force spike associated with high impact exercises.
In animal studies , their low levels have been associated with age-related involuntary changes , including reduced lifespan.
In an incidental study phase , pictures of familiar objects were presented centrally.
In an increasingly aging society , age has become a foundational dimension of social grouping broadly targeted by advertising and governmental policies.
In an independent study of @number@ individuals , four of five modules consistently associated with chronological age , underpinning the robustness of the approach.
In an interventional study , @number@ middle-aged and older subjects were divided into @number@ groups : control and exercise.
In an intra-splenic xenograft experiment using MIA PaCa-2 cells , tumors expressing the nestin double mutant formed fewer liver metastases than tumors expressing wild-type nestin.
In an iterative dialog with the experimenter , the stick was moved until it was at the furthest distance they estimated to be reached successfully.
In an older patient population with multiple comorbidities , whether intravenous antibiotics alone or in combination with surgery lead to superior outcomes remains unknown.
In another analysis , energy deficit percentage needed to reduce BMI by one unit is found to be relatively constant across ages.
In another ongoing study , this methodology has been applied to patients with Lewy body dementia.
In antiretroviral treatment ( ART ) -naive patients , encoded HIV proteins represent pathogenic candidates.
In antiretroviral treatment-controlled patients , epigenetic clock appears to be advanced , and some haplogroups are associated with HIV infection severity.
In a number of cases , anemia remain unexplained.
In a number of cases remain unexplained anaemia.
In an unblinded study , it induced remission in the majority of patients with inflammatory bowel disease.
In any age group , subjects with MetS presented thicker , stiffer or less distensible , and wider large arteries than controls.
In any case , steroid cell tumor should be suspected in postmenopausal women who present with rapid progressive androgen excess symptoms.
In a passive auditory oddball paradigm identifiability and duration of task-irrelevant novel sounds ( novels ) were varied in children aged 7-8 and in adults.
In a pilot experiment , the influence of bacterial lipopolysaccharide on human MP was analyzed using 2-dimensional gel electrophoresis.
In a placebo-controlled cross-over design , participants listened to hypnotic suggestions or a control tape before a midday nap while high density electroencephalography was recorded.
In ApoE e4 carriers , the negative association between the ratio of campesterol to cholesterol and memory reached borderline significance.
In APOE ε3 / ε4 heterozygote carriers , apoE4 levels decrease , indicating that apoE3 levels increase with disease.
In a pooled analysis of three clinical trials , ≤2 % of avanafil and placebo recipients discontinued treatment because of adverse events.
In apoptotic cells , Smac is released into the cytosol and promotes caspase activity by inhibiting inhibitors of apoptosis ( IAPs ) .
In a population-based cohort study of older adults in Saarland , Germany , a detailed lifetime history of smoking was obtained using standardised questionnaires.
In a population-based study on @number@ nondemented individuals aged @number@ years and above , we investigated the relationship between cerebellar volume and cognitive function.
In a post-hoc analysis we examined heterogeneity of temporal trends by age through mixed-effects models for the log-transformed PFAS compounds.
In apparently healthy men , over a wide dose range , testosterone did not adversely affect atherogenic biomarkers.
In applied contexts , they suggest ways of thinking that could enhance well-being in the very old.
In APP / PS2 / Tau the effect was age-dependent , whereas in TASTPM it was detectable from the first investigated time point.
Inappropriate aldosterone levels on a liberal salt diet may mediate the SSBP.
Inappropriate drug use is an important health problem in elderly persons.
Inappropriate entrainment of the circadian clock by light is considered to contribute to the alteration of sleep structure and circadian rhythms in the elderly.
Inappropriate interleukin-6 production is thought to play a role in the development of several age-related conditions including atherosclerosis.
Inappropriate medicine use in older people leads to adverse clinical outcomes.
Inappropriate prescribing can be reduced by adherence to prescribing guidelines , suitable monitoring and regular medication review.
Inappropriate prescribing of medicines may lead to a significant risk of an adverse drug-related event.
In a preliminary study , we found that @number@ mo of DHEA replacement improved insulin action in elderly individuals.
In a previous study , these were defined as vascular risk factors.
In a randomized clinical trial with @number@ older adults , findings from log data analysis and questionnaires revealed a good use of the online platform.
In a randomized cross-over design , participants performed control and exercise conditions with at least @number@ days separating conditions.
In a range of cognition from normal to dementia , factor structures and factor loadings will vary little.
In a RCT , @number@ caregivers , of whom six were lost at baseline , were randomly assigned to two groups.
In a recent issue of Cell , Tawo et al.
In a recent issue of Nature Medicine , Furman et al.
In a recent paper of J. A. Enríquez and coworkers ( Latorre-Pellicer , A. , et al.
In a recent study , we demonstrated that sleep-dependent consolidation of declarative memories is preserved in older adults.
In a recessionary environment with reduced revenue , state Medicaid programs operate under a fixed or shrinking budget.
In a regression analysis , less education and no usual source of care are the strongest predictors of low activation levels in Medicare beneficiaries.
In a regression analysis , s-free T4-index and age remained as the only determinants of the 24h and the @number@ h RAIU.
In a retrospective study conducted in two university hospitals , data were collected on all stroke cases admitted in @number@ and @number@
In a sample of @number@ adult human subjects with a broad IQ range , we investigated the relationship between sleep spindle parameters and intelligence.
In a secondary analysis , results were consistent for cardiovascular disease mortality but only suggestive and non-statistically significant for coronary artery disease and cancer mortality.
In a second case study , we collected @number@ signatures from treatment of human cells with dexamethasone , a glucocorticoid receptor ( GR ) agonist.
In a second experiment , the role of attention was assessed using a go / no-go paradigm.
In a second step we defined seven body types by clustering the meta-measures of all participants.
In a second step , we determined intra- and inter-reader reliability of the LLAC measure.
In a second step , we determined participants ' motion coherence thresholds for vertical and horizontal coarse motion direction discrimination.
In a second step , we tested the hypothesis that microdamage induced through lithotripsy treatment increases bone apposition in aged rats.
In a separate sample of young and old participants , we replicated the age related effect in the assumed light source direction.
In a separate session , older adults ( N = @number@ ) underwent a structural MRI.
In a series of multivariate logistical regression models , we found cognitive restraint to be consistently and robustly associated with both measures of obesity.
In a series of @number@ patients with clinically diagnosed PSP , we found @number@ patient with an intermediate repeat length.
In a series of studies using in transgenic Alzheimer's disease model , we have shown that chronically elevated levels of allopregnanolone accelerated AD development.
In a sex- and age-matched control group ( n = 15 ) , the same questions were answered.
In a sex-stratified analysis , LTL was not associated with handgrip strength in either men or women.
In Asian nations , family ties are considered important.
In a significant proportion symptoms disappear as the child grows , but others have persistent and troublesome asthma which can be life-long.
In a similar manner , there was an age-dependent decrease of serum TGF-β1 levels in CABG patients ( p = 0.0195 ) .
In a slightly alkaline solution , the DEVD-TPE probe displayed almost no fluorescence owing to the dynamic rotation of the phenyl rings in solution.
In a small survey , physicians who have used the GRS report that it has changed the way that patients are assessed and treated.
In a source monitoring test , participants were required to remember whether an animal was associated with poisonousness or nonpoisonousness.
In a Spanish sample with @number@ individuals , subjects aged 20-59 years were selected , whose zinc intake levels fell within the recommended limits.
In a spinal fusion model , aged autografts treated with L-WNT3A demonstrate superior bone forming capacity compared to the standard of care.
In association , during studies on many candidate genes SNPs , positively or negatively correlated with longevity have been identified.
In association with C4d deposition in peritubular capillaries , glomerulitis is a feature of acute antibody-mediated rejection.
In association with elevated MMP-9 , macrophage numbers increase in an age-dependent manner to regulate the ECM and angiogenic responses.
In asthma the stimulation of T cells by environmental antigens can decrease naive cells and sustain activated cells.
In a study on ' healthy aging' , we investigated metabolite spectra in a sample of @number@ healthy volunteers and determined their age dependence.
In a subgroup aged 50-64 years , @percent@ ( @percent@ CI @number@.5-74.5% ) were hypercholesterolaemic.
In a subgroup identified as consistently healthy before follow-up , longitudinal drinking patterns were associated with initial HUI3 scores but not rates of change.
In a subgroup of five subjects , we inhibited NO and PG synthesis before AA administration.
In a subgroup of smokers who received varenicline or nicotine replacement therapy ( NRT ) , the differences were also statistically significant.
In a subsample of @number@ individuals , ADM gene expression was assessed as part of a transcriptomic study of circulating monocytes.
In a subsequent ( apparently unrelated ) task , participants were asked to rate the trustworthiness of the speakers.
In a subsequent multiple regression analysis , eGFR , serum folate , and plasma vitamin C were the relevant independent predictors of tHcy.
In a subsequent recognition task , memory performance of participants receiving intentional encoding instructions was higher compared with those receiving incidental encoding instructions.
In a subset of affected subjects , visual evoked potentials and microperimetry were also obtained.
In a subset of nineteen individuals , a more extensive sampling scheme was performed to examine within-placenta variation.
In a subset of @number@ cases with prominent perivascular WMH , no corresponding demyelination was found in @number@ cases.
In a subset of OA patients , clinically available Computed Tomography images were used to assess joint structure.
In a subset of patients , we also evaluated serum lactate levels after exercise and muscle biopsy results for histology and mitochondrial DNA analysis.
In a subset of subjects , lens density index was independently estimated from dark-adapted spectral sensitivities performed psychophysically.
In a subset of subjects , the distribution of telomere lengths in leukocytes at baseline and @number@ months was measured.
In a \ "super-aging \ " society such as Japan , long-term treatment for postmenopausal osteoporosis is a considerable need.
In a tauopathy mouse model , we have detected seeding activity far in advance of histopathological changes.
In a third phase , the quantitative and qualitative study results will be integrated.
Inattention and hyperactivity / impulsivity are the core symptoms of Attention Deficit / Hyperactivity Disorder ( ADHD ) .
In a unique Danish family , inherited FTD is caused by a mutation in the CHMP2B gene located on chromosome @number@ ( FTD-3 ) .
In a univariate regression model , LPO blood level constituted the only independent factor negatively associated with melatonin oral treatment.
In automatic age estimation , privileged information is unavailable to test images.
In a variety of cell types , ribonucleoprotein ( RNP ) complexes play critical roles in regulating RNA metabolism.
In average falls occurred @number@ times.
In a worst-case scenario , ≤6% of simulated data did not fit reliably.
In babies , gender difference seems to be most likely caused by a difference in maturity rate of the bladder.
In bacteria , oxaloacetate is subject to enzymatic decarboxylation ; however , oxaloacetate decarboxylases ( ODx ) were so far not identified in eukaryotes.
In Bangladesh , life expectancy has increased from about @number@ years in @number@ to @number@ years in @number@
In basal cell carcinoma , the expression of MMP-1 and MMP-9 was detected in all investigated samples.
In base models , variability in weight was significant.
In basic and adjusted models , we correlated the measured metabolites to carotid-femoral pulse wave velocity assessed by applanation tonometry.
In beta band , decrease of connectivity upon eyes opening was more pronounced in younger than in older participants.
In beta cells , it increases insulin secretion , prevents apoptosis , and induces regeneration.
In bicuspidy there is a defective smooth muscle cell differentiation possibly linked to lowered lamin A / C expression.
In binary logistic regression analysis , the relative volume of left hippocampus and age entered the final model of volumetric analysis.
In Biodemography , aging is typically measured and compared based on aging rates.
In biological systems , free radicals can have a dual role , being beneficial in some situations and deleterious in others.
In bioprostheses without any fluoroscopic landmarks , a balloon valvuloplasty may be necessary to identify the appropriate deployment position.
In biopsies without rejections and in C4d ( - ) biopsies of group G0 , glomerular endothelial cell area was not significantly different.
In bivariate analyses , the FI predicted mortality risk in both age groups whereas the metabolic syndrome did so only in the younger group.
In bivariate twin modeling , @percent@ of the correlation between early cognitive ability and midlife depressive symptoms was due to shared genetic influences.
In black young adults , genetic risk scores constructed using loci identified in European and African American samples had similar predictive power.
In blood cells , telomere length did not differ.
In blood plasma , the expression levels of CRAMP increases during human aging.
In bone marrow MSCs , FOXP1 expression levels declined with age in an inverse manner with those of the senescence marker p16INK4A.
In both affected individuals , a missense mutation ( p.P301L ; rs63751273 ) in exon @number@ of the MAPT gene ( chr17q21.3 ) was identified.
In both age groups , anti-PPS IgA or IgM antibody levels were much lower than anti-PPS IgG antibody levels.
In both age groups , correct recollections of person and action details were higher in a Modified Cognitive Interview than a control interview.
In both age groups , high T increased watching time of threatening social stimuli in the Social Playbacks.
In both age groups , RTs were fastest when motion was similar to the expected direction of motion.
In both age groups , the learning curves ( latent time vs. trial number ) were qualitatively similar in shape.
In both age groups trunk roll increased under impaired somatosensation in the narrow-based walking condition ( by @percent@ ) but not in normal walking condition.
In both bivariate and multivariable contexts , the number of comorbid conditions was associated with reduced quality of life.
In both blacks and whites , higher anosmia prevalence was associated with older age and male sex.
In both case series , @percent@ of subjects and physicians rated treatment outcomes on GAIS as much or very much improved.
In both cases , linkage studies and genome-wide association studies found strong links with complement regulatory genes and disease risk.
In both cases , Lp-X levels decreased markedly and the xanthomas disappeared completely after the improvement of cholestasis.
In both cases , the general practitioner considered multifactorial dizziness with several treatable contributory factors.
In both cases , transdermal rotigotine ( @number@ mg / day ) was added to the original dopaminergic therapy.
In both clinical and basic research , straylight ( the functional result of light scattering in the eye ) is commonly measured.
In both cohorts , the lipid pattern was less favourable and HR higher in women , chronic pulmonary disease more represented in men.
In both cohorts , we identified groups of subjects homogeneous for their frailty status and characterized by different survival patterns.
In both conditions , the transplanted cells developed into mature interneurons , functionally integrated into the hippocampal circuitry , and restored normal learning and memory.
In both cross-sectional and longitudinal models , the socioeconomic variables showed the strongest association as risk factors for CRLDS.
In both deficiency states there is often dissociation between the neuropsychiatric and the hematologic complications.
In both developed and developing countries , population aging has attained unprecedented levels.
In both diseases , the detrimental intra- and extracellular deposits have many similarities.
In both diseases , tonic inhibition of T cell trafficking across inflamed endothelium is lost.
In both ethnicities , the strongest associations were centered in a region with a high degree of LD near the AHSG locus.
In both experiments , adults had more time to spare than did children.
In both experiments , individuals ' inhibition and shifting capacities were assessed with the Trail Making Test and the Stroop Test.
In both experiments older adults had more false alarms and showed less accurate recognition than younger adults.
In both experiments , older and younger adults read texts in an italic font and were required to ignore distractor words in an upright font.
In both experiments , participants judged causality in billiard-ball style launching events ; a blue ball approaches and contacts a red ball.
In both experiments , younger and older adults segmented movies of everyday activities into large and small meaningful events.
In both genders , elderly patients had significantly higher Lp ( a ) median concentrations.
In both genders , hip BMD and CSA were significant lower in fracture cases compared with controls.
In both genders , serum 25-hydroxyvitamin D levels were significantly lower in moderate and severe sarcopenic states.
In both group of aged mice , scanning laser ophthalmoscopy ( SLO ) showed the presence of a few autofluorescent foci.
In both groups , ADCS ADL scores declined over @number@ months.
In both groups all main central and peripheral changes that occurred at the onset of passive knee extension were transient , lasting only @number@ s.
In both groups gender had no significant effect on the values of the thoracic kyphosis ( p > @number@ ) .
In both groups , lotion fumigation and external washing of the patients ' knees will be administered twice a day for @number@ consecutive days.
In both groups , M / L was directly related to age ( P < 0.0001 ) .
In both groups , MRPI values were not influenced either by aging or by disease status.
In both groups , patients were subdivided into nocturnal polyuria , decreased nocturnal bladder capacity ( NBC ) , or nocturia by both causes subgroups.
In both groups , people with an FI greater than or equal to the @percent@ limit showed close to @percent@ mortality by @number@ years.
In both groups , performance was positively correlated with inter-hemispheric SC.
In both groups , plasma alanine aminotransferase ( ALT ) was measured at baseline and day @number@ and risk factors for raised ALT were recorded.
In both groups significant correlations were found between the score on the CRQ and performance in neuropsychological tests that measure executive functioning.
In both groups , step adjustments were smaller than required.
In both groups , successful memory encoding performance was significantly correlated with the activation of the right frontal cortex.
In both groups , the greatest percentage was @number@ - @number@ incapacities.
In both groups , the impact of the voice changes was higher in the VR-QOL physical than in the socio-emotional domain.
In both groups , the tooth's total area of the upper right central incisor was recorded.
In both groups , the value of add-power was positively correlated with age ( r = 0.91 ; P < 0.005 ) .
In both groups the variables studied were within the limits of normality for the age.
In both groups , walking faster diminished the occurrence of elevation and increased that of leg lowering.
In both jaws , third molar development occurred symmetrically , and sexual dimorphism was observed at some developmental stages.
In both men and women , A-T-N- was the most prevalent until age late 70s.
In both models , Eng-null endothelial cells were detected in the brain AVM lesions , and formed mosaicism with wildtype endothelial cells.
In both models , NAM treatment substantially decreased ROS levels.
In both muscle groups and genders , older adults had decreased concentric force capabilities.
In both older and young women , the CAR correlated positively with the hPER1 gene expression.
In both overdoses , the onset of Emax occurred on an \ "on-off \ " mode.
In both , @percent@ of patients were women.
In both phases , men were encouraged to visit their physician if the screen results indicated possible cognitive impairment.
In both phases , the survival curves showed a significant difference in all-cause mortality between the three polypharmacy groups.
In both rodents and humans , parathyroid hormone provided either intermittently or continuously suppresses sclerostin levels.
In both samples , a significant prolongation of temporal-order threshold was observed in subjects older than @number@ years of age.
In both samples , the parental mean age of death was positively associated with optimism scores of the offspring.
In both samples we found that , in older adults , ApOE ε4 carriers demonstrated worse everyday memory performance than did ε4 noncarriers.
In both scenarios , mitochondria-derived ROS are important players in senescence initiation.
In both screening arms , cytology results of low-grade squamous intraepithelial lesion or worse triggered a referral for colposcopy.
In both sexes , anxiety had the highest population-attributable risk ( men : @percent@ , women : @percent@ ) .
In both sexes , ASMR declined during 1986-1997 , then increased during 1997-2001 and again declined over 2001-2011.
In both sexes , BMI significantly decreased with age ( p < 0.001 ) .
In both sexes , glabellar lines did not clinically manifest before the age of @number@
In both sexes , most individuals undertook a long period of education and postponed family formation.
In both sexes , the effect of cannabis was robust to adjustment and was unrelated to its acute effects.
In both sexes , the pitch range was significantly narrower in the PD group than in the control group.
In both sexes , there are anatomical and behavioral differences in dealing with bladder control , as well as voiding and incontinence.
In both sexes , UR was positively associated with overweight and protein intake and inversely associated with age.
In both situations , we find poor hygienic conditions , which frequently lead to anemia of inflammation.
In both species , aging cannot operate as a mechanism facilitating natural selection because the pressure of this selection is strongly reduced due to
In both species , older subjects displayed a different pattern of results than young subjects.
In both studies , feeling closer to success memories ( and far from failure ) led to enhanced mood.
In both studies , hyperpigmented spots were evaluated at weeks @number@ and @number@ by quantitative image analysis.
In both studies logarithmic Gaussian models fitted the latency and amplitude data best.
In both studies , subjects were randomly allocated to either a protein ( 2×15 g daily ) or a placebo drink.
In both studies , we found that older adults did indeed report lower rates of intentional mind wandering compared with young adults.
In both studies we found that Openness was related to the directive and self functions of overall usage.
In both studies , young and older participants rated personality trait adjectives on age typicality , valence , and self-typicality.
In both systems the metabotropic pathway augments the ionotropic receptor response.
In both the AD patients and the elderly control group , odor identification ability correlated with performance in cognitive tests.
In both the aspirin and no aspirin groups , @number@ fatal events occurred.
In both the cross sectional and the prospective analyses the prevalence ratio was calculated using Generalized Linear Models.
In both the sexes , vitamin D and calcium supplementation significantly increased serum ionized calcium levels and decreased parathyroid hormone levels.
In both young and elderly subjects , impedance modulus was reduced gradually in the frequency range of @number@.78-8 Hz.
In both younger and aged individuals , the time of sample collection also affected relative numbers of some of the B cell subsets in blood.
In boys , larger left amygdala volumes were associated with better emotional control.
In BRAFi-resistant cells , PAKs phosphorylate CRAF and MEK to reactivate ERK.
In brain tumors , an alternatively spliced form of CAXII is expressed.
In Brazil , the study population carried out in São Paulo in the year @number@ and reassessed in @number@ ( COHORT A ) .
In Brazil , this study is evaluating the elderly population ( @number@ years or more ) in São Paulo since @number@
In budding yeast , progression through stationary phase and quiescence constitute an accepted current model to study some of the mechanisms that determine life span.
In CA3 , CRF1 binding was greater in males before puberty but decreased during puberty , abolishing the sex difference.
In CAD patients , additional reductions in cerebral oxygenation may place them at additional risk of cerebral ischaemia.
In CAD patients , at rest and during hypercapnia , cerebral oxygenation was lower ( P < @number@ vs. young ) .
In CAD patients , rs174537T carriers showed a larger LDL particle size than G / G subjects.
In Caenorhabditis elegans , heat shock factor HSF-1 is known to regulate aging and required for the elongation of longevity by dietary restriction.
In Caenorhabditis elegans , lowering of the ambient temperature has a similar effect.
In Canada , dietitians are involved in the assessment of malnutrition and provide specialized dietary counseling.
In Canada , health care is centrally administered , and controlled by the provincial governments of Canada , under the Canada Health Act.
In Canada , hepatitis C virus ( HCV ) infection results in considerable morbidity , mortality and health-related costs.
In Canberra , a baseline survey and an Older Persons Assembly were followed by modest positive ageing plans.
In cancer cachexia , chronic inflammation is elevated by the immune response in the fight against cancer.
In cancer cells , mitochondrial oxidative phosphorylation ( OXPHOS ) dysfunction has been shown to promote migration , invasion , metastization and apoptosis resistance.
In cancer , differences in module activity potentially represent the heterogeneity of phenotypes important in carcinogenesis , progression , or treatment response.
In cancer , intrinsic and acquired resistance , tumor heterogeneity , adaptation , and genetic instability of cancer cells all hinder cancer-directed therapy.
In cancer patients depression and insomnia are frequent and serious comorbid conditions which definitely require a special attention.
In cancers including breast cancer , mechanistic target of rapamycin is frequently upregulated.
In cancer , these responses are upregulated and maintained.
Incarcerated external hernias , however , are often fatal.
Incarceration is justified on @number@ principles : retribution , rehabilitation , deterrence , and incapacitation.
In cardiomyocytes , modulation of miR-18 / 19 changes the levels of ECM proteins CTGF and TSP-1 and collagens type @number@ and @number@
In Cardiovascular Health Study , the association with mortality and accuracy predicting death were determined with Cox proportional hazards analysis and c-statistics , respectively.
In case @number@ a periapical radiograph showed distal bone loss was interrupted , and the tooth also recovered normal mobility.
In case @number@ Mohs ' chemosurgery could prevent rapid tumor growth and control the bleeding , exudation and offensive odor from ulcerated tumors.
In case @number@ remission of the tumor was achieved by concurrent treatment with local radiotherapy and Mohs ' chemosurgery.
In case of a positive gFOBT result , participants are referred to colonoscopy , independent of sex.
In case of cognitive impairment after surgery , @percent@ were against any surgical intervention.
In case of deficiency and / or aging , CoQ10 oral supplementation is warranted.
In case of hospitalization , risks may be further increased , especially in case of suboptimal dietary intake.
In case of insufficient analgesia , the initial daily dose could be increased gradually.
In case of persistent distress , tracheotomy is mandatory.
In case of significant interaction terms , age-stratified results will be presented.
In case of significant publication bias , the Duval and Tweedie's trim and fill algorithm was used.
In case of thermal changes , physiological mechanisms are enhanced , increasing rates of energy expenditure.
In cases of a known photosensitizer , local and systemic phototoxic or photoallergic reactions can be differentiated.
In cases of deep glabellar lines that cannot be corrected by filler injection , this procedure can be recommended as another option.
In cases of hepatocellular carcinoma and miscellaneous liver tumors , the morbidity and mortality rate did not differ significantly between the elderly and young patients.
In cases , the association with early MI risk remained statistically significant after adjustment for triglycerides ( p = @number@ ) .
In catalase knock-out mice , a decreased hydrogen peroxide removing capacity and increased reactive oxygen species formation were reported.
In cataract surgery , considerations such as preexisting AMD , night vision problems or sleep problems may be considered with the choice of IOL.
In Caucasians , TDP-43 proteinopathy independently correlate with cognitive decline.
In CBT-I and TCC , TELiS promoter-based bioinformatics analyses indicated reduced activity of nuclear factor-κB and AP-1.
In CC genotype of rs564481 , serum creatinine was significantly higher in Kazaks compared with Uygurs ( P < 0.05 ) .
In CD106 ( bright ) MSCs , the abundance of a panel of stemness transcription factors remained unchanged.
In CD4 + T-cells , a greater increase in CTLA-4 expressing cells in older persons was the only difference between the age groups.
In cell cultures , SkQ1 and its analog plastoquinonyl decylrhodamine @number@ ( SkQR1 ) arrest H ( @number@ ) O ( @number@ ) -induced apoptosis.
In cell-free systems , neither superoxide anion-scavenging effect nor inhibition of elastase activity was associated with the suppressive effects of N11.
In cell lysates and exosomes , GGT1 expression correlated with GGT activity.
In cells , both newly synthesized and pre-existing proteins are constantly endangered by misfolding and aggregation.
In cells containing a large amount of NM , cells in aged individuals outnumbered those of younger individuals.
In cells defective for BRCA1 , which is required for efficient HR , the balance between promoting and inhibiting HR is thrown towards inhibition.
In cells depleted of Hec1 , which is essential for end-on attachment , chromosomes show partial and transient congression.
In cells lacking p53 , unchecked telomere shortening drives chromosomal end-to-end fusions and cycles of chromosome fusion-bridge-breakage.
In cells , rapamycin and other rapalogs such as everolimus suppress geroconversion from quiescence to senescence.
In cells with induced p53 , re-activation of mTOR by serum stimulation causes senescence , as an equivalent of cellular growth.
In cellular quality control system , E3 ubiquitin ligases are significant employees for defense mechanism against abnormal toxic proteins.
In centenarians , an increase of pro-inflammatory cytokine production balanced by anti-inflammatory immune response that would promote longevity is observed.
In-Ceram Alumina ( IC ) , IPS e.max Press ( EM ) and Katana ( K ) ( n = 40 ) , were selected.
In cerebral amyloid angiopathy patients , microbleeds often cluster , mostly occipital , and are associated with apolipoprotein E ( APOE ) genotype.
In certain cases , utilizing various combinations of mechanical , optic , acoustic , and electrical energies may be necessary to achieve the desired outcomes.
In certain neurological disorders , attempted fixation results in abnormal fixational eye movements with distinctive characteristics.
In CHD trials , APOE4 carriers supplemented with LC omega-3 were categorized as differential responders to the treatment with regards to CHD risk markers.
In child-care centres , the influence of caregivers on the development of peer interactions seems ambivalent and mixed results are reported in the literature.
In childhood and adolescence , bone formation and resorption were increased , but formation rate was exceeded resorption rate.
In childhood and old age also other rightward spatial biases were observed in linguistic as well as in non-linguistic stimulus conditions.
In childhood frontal lobe epilepsy ( FLE ) , cognitive impairment and educational underachievement are serious , well-known co-morbidities.
In childhood , the peak years of an organ system's increase in size correlate with peak years of cancer incidence.
In children and adolescents , during the development of osteoporosis or after bone fracture , OCN level increases significantly.
In children , bone markers may be useful in diagnostics and treatment management of skeletal diseases but there could be difficulties with interpretation of results.
In children , congenital surgical operations remained constant , accounting for @percent@ of all surgical operations.
In children , early diastolic LV untwisting appears to be less important than in adults.
In children , PH usually presents with a typical phenotype of disturbed body composition , accelerated biological maturity , and subtle immunological and metabolic abnormalities.
In children , T2 relaxation times increase as a result of cartilage microstructure changes in early inflammatory arthritis.
In children , the mean ratio was @number@ ± @number@ and the mean choroidal vascular diameter was @number@ ± @number@ μm.
In China , different age groups of old people may be influenced by different factors.
In China , however , social security old-age benefits are provided in a highly fragmented manner.
In China , where the population is aging rapidly , COPD has become one of the leading causes of disability and a large economic burden.
In CHIP-depleted cells , SirT6 K170 mutation increases SirT6 half-life and prevents proteasome-mediated degradation.
In chronic hyperglycemia , diet and treatment should be reevaluated in order to reduce glucose variability.
Incidence and pathogeny in this specific population remain to be assessed.
Incidence and severity of most psychiatric comorbidities were lower in older subjects.
Incidence , clinical characteristics , and outcome of fungemia were analyzed.
Incidence data from cancer registries were transformed to mortality estimates using separately estimated mortality incidence ratios.
Incidence , in-patient mortality , and hospital costs were calculated.
Incidence is higher in men than women and strongly increases with age ; median age at diagnosis is about @number@ years in developed countries.
Incidence of AC was @number@.0‰ in familiar parkinsonism , @number@.2‰ in genetic parkinsonisms.
Incidence of decompensated cirrhosis will increase @percent@ to @number@ cases by @number@ while incidence of HCC will increase by @percent@ to @number@ cases.
Incidence of dementia / CIND was ascertained by using standard diagnostic criteria.
Incidence of dementia was identified from participant or informant reported physician diagnosed dementia or overall score of informant-completed IQCODE questionnaire.
Incidence of dementia was obtained from health insurance records.
Incidence of generalized anxiety disorder increased with age in the fragile X syndrome group.
Incidence of hypoglycaemia and weight gain was lower with detemir than with glargine in both arms.
Incidence of mobility disability was determined in participants able to walk @number@ m at baseline.
Incidence of NAFLD was based on historical and projected changes in adult prevalence of obesity and type @number@ diabetes mellitus ( DM ) .
Incidence of nocturia newly diagnosed in a pregnancy drops down by @percent@ in @number@ month after the child birth.
Incidence of nocturia rises significantly with age.
Incidence of prostate hyperplasia and occult prostate cancer in elderly are both high.
Incidence of VI increased strongly with older age , and independently with being diabetic.
Incidence rate and confidence interval of each event were estimated using quasipoisson model.
Incidence rate of CIND was @number@ per @number@ person-years.
Incidence rate ratios were calculated using Poisson regressions while adjusting for sociodemographic characteristics and the presence of mental and physical disorders.
Incidence rates of all the risk factors of interest increased with advancing age.
Incidence rates of ED visits and length of ED stay were calculated.
Incidence rates of specific adverse events were generally similar between the two groups , with the exception of hypoglycemia.
Incidence rates were estimated to increase constantly for female breast cancer , colorectal cancer in men and melanoma in both sexes.
Incidence strongly varies globally and is closely linked to elements of a so-called western lifestyle.
Incidence was also higher among women.
Incidence was calculated using published data and Japan's population statistics.
Incidence was higher in the rural cohort as compared with the urban cohort ( P < @number@ ) .
Incident AF was ascertained through yearly follow-up questionnaires.
Incident AF was identified by electrocardiograms during CHS visits , hospital discharge diagnoses , and Medicare files , including outpatient and physician claims diagnoses.
Incidentally , in some studies it was noted that high-dose salicylate treatment reduced blood glucose concentrations.
Incidental VTE included @number@ pulmonary embolism , @number@ deep venous thrombosis of the extremities , and @number@ thromboses of the cava or splanchnic veins.
Incidental white matter lesions ( WML ) are a common neuroradiological finding in elderly people and have been linked to dementia and depression.
Incident breast cancer cases diagnosed in @number@ of residents in the southern region of Portugal were included.
Incident cases included individuals with no RVO claims in @number@ but with RVO claims in the years @number@ through @number@
Incident cases of diabetes were identified annually by self-reported initiation of using oral medications or insulin for diabetes > @number@ years follow-up.
Incident cases of mild NCD were ascertained at follow up after an average of @number@ moths ( range : 10-62 ) .
Incident cases of probable dementia and mild cognitive impairment were centrally adjudicated.
Incident cognitive impairment was defined as either new onset of adjudicated diagnosis of mild cognitive impairment or dementia.
Incident CVD event was defined as any adjudicated CVD event.
Incident delirium was significantly reduced ( 'before ' = @percent@ ; ' after ' = @percent@ ; P = @number@ ) .
Incident dementia and less severe cognitive impairment were also highly prevalent.
Incident dementia was assessed according to the international guidelines.
Incident depressive symptoms were defined by a score ≥6 on the 15-item Geriatric Depression Scale and / or use of antidepressant medication.
Incident diabetes was based on self-report , use of antihyperglycemic medicines , or HbA1c ≥6.5% during @number@ years of follow-up.
Incident disability and requirement for nursing care were assessed semiannually through self-report.
Incident disability in ≥1 ADL defined the outcome of interest.
Incident DM was ascertained via annual follow-up questionnaires and validated in a subsample by a review of medical records.
Incident DM was defined through @number@ by medication use or blood glucose levels.
Incident eGFR < 60 ml / min per @number@ m ( @number@ ) developed in @percent@ .
Incident falls were prospectively assessed over a 50-month study period.
Incident falls were recorded over study follow-up.
Incident fractures ( @number@ men ) were X-ray verified.
Incident fractures occurring after the initial medication assessment until @date@ were confirmed by radiographic reports.
Incident fractures represented @number@ % of this cost , long-term fracture care @number@ % and pharmacological prevention @number@ %.
Incident fractures represented @number@ % of this cost , long-term fracture care @number@ % and pharmacological prevention @number@ %.
Incident heart failure rates were higher in those with SBP less than @number@ mmHg than in the reference group.
Incident HF was validated by a centralized Events Committee.
Incident hospitalizations were determined from claims data.
Incident hypertension was defined with the 24-hour , day-time and night-time ambulatory blood pressure measurements and antihypertensive treatment use , at two-years of follow-up.
Incident mobility and ADL disability was followed-up on median @number@ years ( range @number@.6-7.8 years ) .
Incident mobility disability was defined as having much difficulty or unable to walk @number@ m or climb-up @number@ steps.
Incidents of physical aggression were assessed using staff report.
Incident stroke does not affect this association , suggesting that a lower cerebral vasomotor reactivity reflects a generally impaired vascular system.
Incident T2D was self-reported and validated primarily through the collection of supplementary information from participants.
Incident VH could be predictive of concomitant AD / PD pathology even when criteria are not met for a second diagnosis.
Incident visually significant cataract was significantly greater for the rural cohort between @number@ and @number@ years old.
Incident vocal fold paralyses and directed interventions were identified.
Incident wave amplitude ( IWA ) and reflected wave amplitude ( RWA ) were obtained by the wave separation analysis.
In CI or dementia , some associations were found in primary motor cortex , hippocampus , prefrontal cortex and basal ganglia.
Incipient cancer cells confronting these telomere barriers must disable p53 signaling to avoid senescence and eventually up-regulate telomerase to achieve cellular immortality.
Incisions at donor sites healed by first intention.
In CKD , dysexecutive mild cognitive impairment and vascular dementia are also more prominent than other subtypes.
In CKD , early onset of Klotho deficiency contributes to renal FGF23 resistance and a maladaptive increase in circulating FGF23.
In Clarke's nucleus , neuronal loss and gliosis were found.
In clinical medicine , angiogenesis inhibitors that target VEGF signalling such as bevacizumab are used as anti-cancer drugs.
In clinical Parkinson's disease , levels of LRRK2 negatively correlated to disease duration and were comparable with controls.
In clinical practice , asthma that occurs in the most advanced ages is often diagnosed as COPD , thus leading to undertreatment or improper treatment.
In clinical practice comprehensive assessments to identify those at risk of malnutrition including associated factors are needed.
In clinical practice , identifying positive and negative attitudes toward older patients is very important to improve quality of care provided to them.
In clinical practice , it is important to weigh costs and benefits of screening given the rather low-predictive power of screening instruments.
In clinical practice it would be recommended to add regular physical activity to balanced diet and drugs to achieve better therapeutic results.
In clinical practice , plain X-ray and , in selected cases , computed tomography or magnetic resonance imaging , are performed.
In clinical practice , the reticulocyte count is the most useful method to estimate red cell life span and red cell production.
In clinical prostate cancer samples , the RUNX1 expression level is negatively associated with EZH2 and that RUNX1 loss correlated with poor prognosis.
In clinical research usually several parameters are subsequently measured in the same skin areas.
In clinical setting , magnetic resonance imaging provides the most important information in the diagnosis of PML.
In clinical settings , the differentiation of ET and dystonia may also be very challenging.
Included articles were compared between research teams and assessed for quality and risk of bias.
Included in this feasibility report are physicians ' answers to the Sequential Questions and Answers pre- and posttests and their brief questionnaire replies.
Included in this population estimate is the relative growth in the number of older adults of racial and ethnic minority descent.
Included participants from the REasons for Geographic And Racial Differences in Stroke ( REGARDS ) study were aged 47-93 years.
Included patients were between the ages of @number@ and @number@ and were continuously enrolled for @number@ months pre- and post-index.
Included studies were critically assessed regarding their risk of bias , and methodological shortcomings.
Included studies were grouped according to treatment type.
Included subjects had normal cognitive and movement disorder assessments at study entry.
Included were a total of @number@ CHD cases and @number@ CHD-negative controls , all with type @number@ diabetes.
Included were English language randomized controlled trials of case management for community dwelling dementia patients and their caregivers evaluating costs , institutionalization and hospitalization.
Included were neurology consultants and residents , a medical librarian , clinical epidemiologists , and content experts in the field of behavioral neurology.
Included were @number@ AL residents from @number@ facilities.
Included were @number@ patients , suffering of a rotator cuff tear with shoulder mobility ranging from pseudoparalysis to free mobility.
Included were @number@ persons @number@ yrs or older with one or more activity of daily living or instrumental activity of daily living-only activity limitations.
Including all covariates and all leisure activities simultaneously , only mid-life political and mental activities remained significantly related to later life cognition.
Including both the age groups , the overall circadian variation of the AMH levels did not reach statistical significance ( P = @number@ ) .
Including criteria consisted of IPSS more than @number@ PSA lower than @number@ RT carcinoma excluded and prostate size more than @number@ cm3.
Including HAL in the risk assessment compensates for this confounding by skeletal size and provides for more accurate assessment of fracture risk.
Including HZ vaccination in its citizens ' lifetime immunization calendar can reinforce Europe's commitment toward active , healthy aging.
Including older individuals in decisions about food can increase the desire to eat and improve quality of life.
Including older individuals in decisions about food can increase the desire to eat and improve quality of life.
Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.
Including those with borderline values , the proportion of children vulnerable to VAD threats reached @percent@.
Inclusion and exclusion criteria were used to screen identified study abstracts.
INCLUSION CRITERIA : a negative and successively positive ( > six months ) HIV antibody test.
INCLUSION CRITERIA : consecutive cardiac surgery patients , aged ≥65.
Inclusion criteria for our literature review required antipsychotic and / or antidepressant drug-induced QTc interval prolongation.
Inclusion criteria for this analysis were body mass index ≥ @number@ kg / m and biomarker measurement.
Inclusion criteria included : aging adults or those with ambulatory problems , intervention or targeted training , and clinical trial.
Inclusion criteria included all English language publications in the databases PubMed and Scopus , through to the end of @date@ .
Inclusion criteria included articles classified as randomized controlled trials ( RCT ) , controlled trials ( CT ) and uncontrolled trials ( UT ) .
Inclusion criteria included at least @number@ months ' follow-up , standardized photos with no makeup or jewelry , and no subsequent cosmetic procedures.
Inclusion criteria included : biologically born female ; aged @number@ years or older ; diagnosis of HIV / AIDS ; and English speaking.
Inclusion criteria included the following outcomes : mortality , aspiration pneumonia , pressure sores , nutritional parameters and quality of life.
Inclusion criteria included were having ECG parameters such as QRS duration measures and a DNA sample within the same subject.
Inclusion criteria involved those listed in ISO 389-1 ( @number@ ) and the @date@ ( @number@ ) .
Inclusion criteria : minimum age of @number@ years , individual in good health conditions according to a pre-established protocol published by the health care service.
INCLUSION CRITERIA TYPES OF PARTICIPANTS : The current review included studies of adult women who had experienced UI.
Inclusion criteria were age over @number@ years , normal status and competence.
Inclusion criteria were biopsy-proven sarcoidosis , disease duration greater than @number@ year , documented smoking status on chart review and documentation of sarcoid-related eye disease.
Inclusion criteria were minimal to include a sample of older adults with a wide range of sensory and cognitive abilities.
Inclusion criteria were : no clinical evidence of cardiovascular , renal or diabetic diseases.
Inclusion criteria were the absence of cardiovascular risk factors or presence of not more than one.
Inclusion of additional MRI tests increased lesion differentiation.
Inclusion of age and accuracy accounted for almost all of the unexplained variance in location of interference-related activation within MFC.
Inclusion of aging genes set showed @number@ neurological and @number@ psychiatric diseases have the strong association with aging.
Inclusion of AI in the overall model reduced the gender difference in E / A by @percent@ and rendered it nonsignificant.
Inclusion of biomarkers or other risk factors may further enhance the models.
Inclusion of failed automated segmentations led to worsening of reproducibility of both automated methods for 1-year raw and percentage volume change.
Inclusion of relevant older publications was assured by cross-checking references.
Inclusion of subjective cognitive decline or mild functional impairment did not improve dementia prediction accuracy.
Inclusion of the new CMF into the regression models provided significant additional predictive power beyond FI-32 on self-rated health , but not IADL dependency.
Inclusion of this group is important as having Down's syndrome is a significant risk factor for early-onset dementia.
In CMV seropositives , this subgroup had lower proportions of late-differentiated CD4 + and CD8 + T cells and weaker anti-CMV immunoglobulin G reactivity.
IncobotulinumtoxinA , also known as NT @number@ is a new botulinum toxin type A ( @number@ kDa ) that is free from complexing proteins.
IncobotulinumtoxinA ( @number@ U ) was administered to each band.
IncobotulinumtoxinA was well tolerated and improved patients ' self-perception.
In cognitively intact elderly subjects , 25OHD levels below @number@ nmol / L are already predictive of global cognitive dysfunction at @number@ years.
In cognitively normal individuals , neurodegeneration biomarkers did not differ between Aβ-N + and Aβ + N + cases.
In collaboration with a local Aging in Place program , we conducted a three-month study with sixteen participants from an independent living facility.
In collecting data we used the Barthel Index and MOS SF-36.
In combination with gemcitabine , PMAb83 conferred enhanced survival of xenografted mice by about twofold compared to gemcitabine alone.
In combination with GFAP , AQP4 differentiated plaques into three progression stages under light microscopy.
In combination with nuclear / nucleolar proteins , NS has been demonstrated to be involved in cell-cycle regulation and telomere maintenance.
Income and sexual decision-making power were statistically significant in predicting the use of condoms.
Income did not affect anxiolytic use , but antidepressant and alternative medicine use was associated with higher income.
Income effects do not dominate substitution effects , even at the high level of compensation found here.
Income groups were dichotomized as < $ 14 , 000 / year ( lowest income group ) or ≥ $ 14 , 000 / year.
Income was logarithmically associated with brain surface area.
Income was not significantly associated with elevated ACR ( aOR @number@ @percent@ CI @number@.7-4.5 ) .
In common with other targeted kinase inhibitors , tumours are likely to adapt and acquire resistance to mTOR inhibitors.
In community-dwelling elderly , AED use was associated with an increased probability of use of all types of psychotropics.
In community-dwelling older adults , low hemoglobin concentrations and anemia were independently associated with increased frailty risk.
In community surveys , older adults with this genotype have been found to have lower scores on neuropsychological tests than those who do not.
In comparison , antimicrobial peptide LL-37 prevented HSV-1 infection independently of its sequence of addition.
In comparison , data-driven methods of physiological noise correction show comparable benefits for both young and old cohorts.
In comparison , how changes in growth signaling pathways impact telomeres and telomere-binding proteins remains largely unexplored.
In comparison , labeling of N-terminus ( Alz50 ) was enhanced.
In comparison , @number@ HIES subjects expressed negative to low antibody levels to all of these antigens ; none had colitis.
In comparisons between sexes , males are found to have more brain metabolism than females in bilateral visual cortices and cerebellum.
In comparisons with other ethnic groups , Korean subjects had thicker cortices than their American , European , and African counterparts.
In comparison to alpha-blocker monotherapy , finasteride was less effective than either doxazosin or terazosin , but equally effective compared to tamsulosin.
In comparison to commercial and technical fields , physic and psychological complaints are lower and work pleasure is much higher.
In comparison to consecutive , fixed-window approaches , our approach is likely to group nearby variants together.
In comparison to inpatient , outpatient setting seems to reduce the risk of postoperative cognitive disorders after surgery.
In comparison to NP patients , the total peripheral vascular resistance was @percent@ higher in PE women and @percent@ higher in CH patients.
In comparison to other environmental allergens , the sensitizing potential of molds is estimated to be low.
In comparison to parallel Cu / Zn superoxide dismutase worm models , transgenic full-length TDP-43 , including the WT protein , was highly neurotoxic.
In comparison to participants without mild parkinsonian signs , presence of cardiovascular but not cerebrovascular disease at baseline was associated with new-onset mild parkinsonian signs.
In comparison to the English-speaking stream , the Mandarin-speaking stream achieved fewer improvements in outcomes and goals.
In comparison with baseline , a significant decline of reported pain / discomfort ( P = 0.047 ) was found.
In comparison with clinical data , this value is much smaller than that seen from blood vessel hardening.
In comparison with immunosuppressive therapy , chemotherapy , radiation or surgical removal of the tumor could provide better remission of the neurological symptoms.
In comparison with its human βAR counterpart , zebrafish β2aAR expressed in HEK293 cells appeared to exhibit a unique binding affinity profile for adrenergic ligands.
In comparison with many other organs , estimation of the total cell numbers in the testes is particularly sensitive to methodological problems.
In comparison with micellized lutein , PLGA-NP lutein improved the Cmax in rat plasma by @number@.6-fold and in selected tissues by ⩾ @number@.8-fold.
In comparison with normal ducts , telomere length was decreased in PanIN-1 , @number@ and @number@ and cancer.
In comparison with other modalities , the recognition of emotion in music has received little attention.
In comparison with other organs , kidney has an unusually wide range of oxidative status , ranging from the well-perfused cortex to near-anoxic medulla.
In comparison with other primate species , humans have an extended juvenile period during which the brain is more plastic.
In comparison with WT mice , the urinary excretion of carnosine-propanols was decreased in AR-null mice.
Incomplete suppression by low-dose aspirin treatment of thromboxane ( TX ) metabolite excretion ( urinary 11-dehydro-TXB2 ) is predictive of vascular events in high-risk patients.
In concert , several human Smrt gene polymorphisms are found to nominally associate with type @number@ diabetes and adiponectin levels.
In concert with the previous studies , our data suggest a role of the MR in memory function.
In conclusion , 18F-FDG uptake in aortic segments increases with age irrespective of genders.
In conclusion , AA efficiently protected human chondrocytes against damage induced by H2O2 by regulating multiple regulatory pathways.
In conclusion , a combination of the latter two factors seems to underlie the age-related changes in manual aiming behaviour.
In conclusion , acute RE results in UPR activation , irrespective of age.
In conclusion , adhering to the DASH diet is beneficial for long term BP control and reduction of stroke risk in this Chinese population.
In conclusion , advanced age should no longer be considered as an exclusion criterion for PT.
In conclusion , advancing age is associated with a greater magnitude and delayed recovery from endothelial I / R injury in humans.
In conclusion , AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE ( @number@ ) generation also in the presence of plasma proteins.
In conclusion , age did not influence the response of specific mitochondrial transcripts , proteins , and DNA to a bout of RE.
In conclusion , ageing is associated with decoupling of QT variability from heart rate variability.
In conclusion , age-related decrease of SIRT1 expression in PBMC might in part result from overexpression of miR-34a and miR-9.
In conclusion , age-related intrinsic alterations in signaling responses to osteoanabolic agents like PTH may contribute to cellular and tissue aging of the human skeleton.
In conclusion , age-related rise in adiponectin levels observed in Africans may not be due to renal impairment.
In conclusion , aging induces alterations of the γδ T cell response that might have negative implications for vaccination efficacy.
In conclusion , aging is associated with longer PWD and PA-TDI duration along with a decrease in LA reservoir function.
In conclusion , A-IGF1R / Asp-IRS2 / Val-UCP2 allele combination is associated with a decreased all-cause mortality risk and with an increased chance of longevity.
In conclusion , ALA therapy reduces serum levels of common markers of inflammation in ablated patients.
In conclusion , almost @percent@ of healthy male subjects displayed abnormal AMS scores.
In conclusion , although metabolic and inflammatory symptoms of obesity are displayed in juveniles , their vitD levels are unaffected.
In conclusion , ambulatory BP monitoring improves the detection of hypertension by @percent@ in PD , compared with office evaluation.
In conclusion , among various testosterone values , TT is the most reliable indicator of MetS in middle-aged Japanese men.
In conclusion , an 18-month intensified GP's intervention had limited effect on lifestyle habits.
In conclusion , an unbiased screen across species uncovered several so far unrecognized molecular pathways for cellular aging that are conserved in evolution.
In conclusion , aPWA is independently associated with AF in the general population.
In conclusion , ARA and DHA may be beneficial in preventing and / or improving age-related declines in brain and cardiovascular system function.
In conclusion , ASCVD risk factors are prevalent in adults with CHD.
In conclusion , a specific class of mutations in PDGFRB causes a clinically recognizable syndromic form of skeletal overgrowth.
In conclusion , autoantibody signatures may become a promising approach to noninvasive CRC screening.
In conclusion , autophagy appears to be better maintained in members of families with extended longevity and positively correlates with improved T-cell function.
In conclusion average CNR in Group1 represents the range of healthy subjects.
In conclusion , bicarbonate supplementation does not appear to improve insulin sensitivity or glucose control in non-diabetic older adults.
In conclusion , black soy peptide supplementation may be beneficial for controlling fasting blood glucose levels and 2-hour PG levels.
In conclusion , BMS-777607-induced chemoresistance is associated with cell polyploidy and senescence.
In conclusion , body composition changes were related to nutrient intakes in elderly ( @number@ years or older ) men but not elderly women.
In conclusion , both team training and resistance training improved physical function , psychological well-being , and quality of life.
In conclusion , both the ultrasonic speed of sound and the attenuation coefficient of breast tissue are age related.
In conclusion , brain atrophy of aging in the absence of dementia is related to vascular disease but not hippocampal atrophy.
In conclusion , brain regions with more lesions in connecting WM had lower glucose metabolism and lower Aß deposition.
In conclusion , by @number@ cardiovascular deaths attributed to reduced GFR outnumbered ESRD deaths throughout the world.
In conclusion , by repression of Sirt4 , Lsd1 directs the epigenetic control of TSC immortality via maintenance of metabolic flexibility.
In conclusion , caring for elderly diabetic patients poses unique challenges.
In conclusion , CBF and CVR were successfully investigated using a protocol that causes minimal or no discomfort for the participants.
In conclusion , CCTA is an effective method for measuring age-related differences in the burden of individual coronary plaque subtypes.
In conclusion , CD4 : CD8 ratio normalization occurs rarely , even after several years of ART.
In conclusion , CD4 + NKG2D + represent a subset of highly differentiated T cells which characterizes the senescence of the immune system.
In conclusion , CD5 may be a useful marker to identify memory T-cell subsets with distinct responsiveness to the homeostatic cytokine IL-15.
In conclusion , C. digitatus extract may serve as a new source of antiplatelet agents for food and nutraceutical applications.
In conclusion , cholinesterase-based analytical methods should be avoided for DSM titration in skin penetration studies.
In conclusion , circulating AGEs induce NADPH-dependent ROS generation in vascular aging in both in vitro and in vivo models.
In conclusion , circulating IL-6 levels may be interactively influenced by age and menopause.
In conclusion , CMV infection did not explain poor responsiveness to influenza vaccination in residents of long-term care facilities.
In conclusion , cognition was not clearly associated with attendance in the @number@ participants starting the MI-WP , and average attendance was good.
In conclusion , core stability training added to SB did not result in STS reps improvement.
In conclusion , CR interacts with both patients ' cognitive features and WMLs in modulating the impact of AD pathology.
In conclusion , criteria are identified for the creation of a revised and potentially more effective instrument to measure gerotranscendence.
In conclusion , CT provides a robust exercise regimen to improve muscle mitochondrial outcomes and physical characteristics independent of age.
In conclusion , culture appears to influence positively caregivers ' beliefs and perceptions of caregiving in Belize.
In conclusion , currently , about half of the patients with pyogenic spondylitis demonstrate atypical MRI findings in the university hospitals in Japan.
In conclusion , decline in estrogen production is a major cause of bone mineral decrease.
In conclusion , decrease in muscle strength and muscle mass in older patients is dependent on the type of admission.
In conclusion , delivery of lutein with polymeric NP may be an approach to improve the bioavailability of lutein in vivo.
In conclusion , different component clusters of MetS showed varying associations with arterial stiffness ( PWV ) .
In conclusion , DMAb treatment had no effect on progression of AC or incidence of CV adverse events compared to placebo.
In conclusion , eggshell calcium was more effective in increasing bone mass than calcium carbonate in postmenopausal Vietnamese women.
In conclusion , EG sufficiently suppressed eye wrinkle formation by decreasing various roughness measures on the basis of assessment with non-invasive devices.
In conclusion , E-HDL and gA-I-rHDL share similar physiologic properties in macrophages and human dermal fibroblasts.
In conclusion , elevated markers of endothelial dysfunction are associated with lower CBF in older adults at risk for cardiovascular disease.
In conclusion , endometriosis is associated with increased FF oxidative stress ( OS ) in patients undergoing in vitro fertilization ( IVF ) .
In conclusion , endurance training per se increases PFO in moderately overweight men.
In conclusion , environmental factors that affect children's intellectual development lead to three patterns of brain structural change.
In conclusion , enzalutamide is a convenient , effective and well tolerated treatment for chemotherapy-naïve men with metastatic CRPC who are asymptomatic or mildly symptomatic.
In conclusion , exposure to CS , induced SRB1 post-translational modifications in sebocytes and this might affect sebocytes / skin functionality.
In conclusion , extra care should be taken when anticoagulants are administered to elderly patients with renal impairment.
In conclusion , falls predict a long-term reduction in the physical component of HRQoL in the general elderly population.
In conclusion , fibroblasts isolated from intrinsically aged skin exhibit some , but not all , molecular hallmarks of cellular senescence.
In conclusion , for the first time , we demonstrated prognostic impact of epigenetic biomarkers that reverses with advancing age.
In conclusion , for the older adult , the SMBT appears to be highly reliable test of upper body power.
In conclusion , further epidemiological and pathophysiological insight is warranted.
In conclusion , Gadd45a plays a significant role in HSC stress responses.
In conclusion , glycoform analysis has diagnostic potential in neurological diseases.
In conclusion , gynaecologists are more knowledgeable about fertility and assisted reproduction , while more restrictive towards social oocyte freezing.
In conclusion , HAIE and NNHCA-IE have important epidemiological and prognostic implications.
In conclusion , high- and low-resistance exercises ending with muscle failure may be similarly effective for hypertrophy.
In conclusion , higher endothelial cell adiponectin levels are associated with higher vascular endothelial function , independent of circulating adiponectin levels in older adults.
In conclusion , higher levels of SkM HSP70 protect against insulin resistance development during healthy aging.
In conclusion , higher midlife 25 ( OH ) D concentrations were linked to better outcomes concerning short-term and working memory.
In conclusion , higher serum IGF-1 levels in middle age are associated with risk of AD disease in older age , independent of APOE genotype.
In conclusion , HIPRT was effective at increasing muscle mass and strength without promoting changes in cardiovascular function or autonomic neural regulation.
In conclusion , histopathologic study remains as the gold standard technique to identify the responsible filler.
In conclusion , HIV-positive GBM have significantly increased odds for key self-reported comorbidities.
In conclusion , HMB appears to be effective for enhancing muscle mass and strength in the elderly.
In conclusion , hOBs from elderly individuals express more IL-6 mRNA and less OPG and TGF-β1 mRNA than hOBs from young individuals.
In conclusion , hypertension and dyslipidemia , but not fasting plasma glucose , dissociate from central obesity with advancing age.
In conclusion , IL-6 genotype affects CK and IL-6 in response to ERE.
In conclusion , IMT increased with aging , and it was linked to some clinical parameters of atherosclerosis and lifestyles in children.
In conclusion , increased bone mass in Lrp5-HBM patients seems to be caused primarily by changes in trabecular and cortical bone mass and structure.
In conclusion , in non-demented persons of @number@ years and older , general cognition deteriorates with aging.
In conclusion , in normal elderly CSF tau markers were associated predominantly with lower GM estimates in structures typically affected early in the AD process.
In conclusion , in patients with CHD and depression , SSRI medication decreases depression symptoms and may improve CHD prognosis.
In conclusion , intentional weight loss in obese / overweight people is associated with improvements in performance across various cognitive domains.
In conclusion , in this study , we show that mtDNA content decreases with age and that low mtDNA content is associated with familial longevity.
In conclusion , intradermal BoNTA injection can be considered as an effective method for facial rejuvenation.
In conclusion , ITB led to spurious beneficial associations of beta-blocker use among cancer patients.
In conclusion , it is generally accepted that vitamin D in combination with Ca reduces the risk of non-vertebral fractures particularly those in institutional care.
In conclusion , latent toxoplasmosis is widespread in older adults and may primarily affect immediate rather than delayed memory , particularly in White Americans.
In conclusion , life events stress may have a negative impact on the cortisol : DHEA ratio in older adults.
In conclusion , local IGF-I stimulated tendon protein synthesis in both young and old men , despite lower systemic IGF-I levels in the old group.
In conclusion , long sleep duration was associated with a greater burden of white matter lesions in this stroke-free urban sample.
In conclusion , long-term use of HRT was associated with subtle , but significant , differences in muscle transcript profiles.
In conclusion , lower DAN-DMN cross-talk is associated with lower memory in aMCI , where such effects are buffered by higher CR.
In conclusion , low vitamin D status was common in the elderly of subtropical rural areas.
In conclusion , major cardiovascular-related comorbidities are prevalent among HIV-positive adults in the Bronx , especially older and obese individuals.
In conclusion , major diagnostic limitations and the systematic bias of hysterectomy make it difficult to draw firm conclusions from existing evidence.
In conclusion , many modifiable lifestyle and dietary factors were associated with low serum 25 ( OH ) D levels in Korean young adults.
In conclusion , masters runners demonstrated sustained CK-MB elevation , which may suggest greater cardiac stress.
In conclusion , Med + CoQ diet improves oxidative DNA damage in elderly subjects and reduces processes of cellular oxidation.
In conclusion , medial temporal and-parietal FDG-PET and executive function show a clinically acceptable accuracy for predicting clinical progression in elderly HC subjects.
In conclusion , melatonin may be a promising candidate for future research of agents that modulate smooth muscle motility.
In conclusion , melatonin secretion was significantly and inversely associated with WBC and PLT counts in the general elderly population.
In conclusion , meta-analyses confirmed the efficacy and good tolerability of Ginkgo biloba extract EGb @number@ in patients with dementia.
In conclusion , MHY908 improved the hyperinsulinemia-induced pro-inflammatory response through NF-κB inactivation and FoxO1 activation in aged rat kidneys.
In conclusion , mitochondrial topoisomerase I dampens mitochondrial transcription and thereby alters respiratory capacity.
In conclusion , mPGES-1 inhibition elevates CD80 expression by tumor-associated phagocytes to restrict tumor growth.
In conclusion , mtDNA levels in CSF show a high interindividual variability , with great overlap within phenotypes and presents low sensitivity for AD.
In conclusion , net vestibular-evoked muscle responses led to smaller short and larger medium latency peak amplitudes in anteroposterior forces for the old.
In conclusion , notwithstanding comparable WM performance , the two groups showed consistencies and differences in the WM activated networks.
In conclusion , Nrf2 could influence UVA-mediated MMP-1 upregulation through the MAPK / AP-1 signaling cascades.
In conclusion , obesity is associated with larger LV mass , worse symptoms , lower exercise tolerance , and labile obstructive hemodynamics in HC.
In conclusion , obesity is associated with worse motor performances , a higher risk of disability , and faster motor decline.
In conclusion , offspring from long-lived siblings are marked by enhanced peripheral glucose disposal.
In conclusion , older adults with a poor appetite may have specific food preferences.
In conclusion , one year of exercise training significantly improved physical fitness and lifetime risk for cardiovascular disease without affecting endothelial function or arterial stiffness.
In conclusion , only vitamin C plasma levels appear to be selectively associated with the risk of increasing C-IMT.
In conclusion , orexins are widely distributed and involved in a large variety of biological activities.
In conclusion , our data provides genetic evidence that APC / C activity in the adult forebrain is required for cognitive function.
In conclusion , our data showed a positive association between RBC membrane cis-palmitoleic acid and CHD risk in male physicians.
In conclusion , our data suggested that PEAL induced caspase-dependent apoptosis in several human leukemic cells including U937 cells.
In conclusion , our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.
In conclusion , our findings demonstrate a localization-dependent adaptation to immobilization in glycogen and mitochondria content of skeletal muscles of both young and old individuals.
In conclusion , our findings demonstrate that rs515071 in ANK1 is a novel genetic risk for LOAD susceptibility in Han Chinese.
In conclusion , our findings identify a novel physiological role for monomeric Aβ1-42 and RAGE in neuronal differentiation.
In conclusion , our findings indicate a non-canonical ( nutrient- and energy-independent ) mechanism underlying the pro-autophagic bioactivity of decorin via PEG3 and TFEB.
In conclusion , our findings indicated a novel role of RecQL4 in the regulation of autophagy / mitophagy in U2OS cells.
In conclusion , our knowledge of the conservative treatment modalities for cSDH is sparse and based on small case series and low grade evidence.
In conclusion , our novel data demonstrates that higher lycopene consumption / circulating concentration is associated with a lower risk of PCa.
In conclusion , our observations suggest that the pathology of HDLS may initially be characterized by multifocal lesions in subcortical white matter regions.
In conclusion , our results demonstrate that immunosuppressive therapy following kidney transplantation is effective in patients older than @number@ years.
In conclusion , our results demonstrate that total loss of PINK1 leads to an increased sensitivity to alpha-synuclein-induced neuropathology and cell death in vivo.
In conclusion , our results give preliminary evidence for stronger cognitive training improvements of female compared to male MCI patients.
In conclusion , our results indicate that SIH is a superior hyperhydrating technique than , and proves to be a worthwhile alternative to , GIH.
In conclusion , our results provide further evidence regarding the relation between diet and SCFA concentration in the elderly.
In conclusion , our results suggest that BMP2 overexpression in NPC enhances proliferation , invasion and EMT of tumor cells through the mTORC1 signaling pathway.
In conclusion , our results suggest that caveolin is an important regulator of glucose metabolism that can enhance insulin signals.
In conclusion , our study showed a later age of puberty in this population correlated with PFC concentrations.
In conclusion , our study supports suggestions that epigenetic alterations could play a role in smoking-associated disproportionate aging as reflected by TL.
In conclusion , papillary and follicular thyroid cancers with bone metastasis have a high rate of mortality.
In conclusion , parental longevity was positively associated with optimism in adult offspring , suggesting a partial linked heritability of longevity and optimism.
In conclusion , partial mtDNA depletion to a degree comparable to that seen in aged human islets impaired mitochondrial function and directly decreased insulin secretion.
In conclusion , pathogenic bacteria cause a significant proportion of acute exacerbations of COPD.
In conclusion , pathogenic variants in TBK1 are rare but could be responsible for sALS in a small number of Korean patients.
In conclusion , patients visiting outpatient GEM services in Taiwan are old and well-educated , and they possessed various functional impairments.
In conclusion , patients with HACO bacteremia had different host factors compared with those with CA bacteremia.
In conclusion , patients with mild ED should be closely evaluated for cardiovascular comorbidities.
In conclusion , poor levels of agreement existed between saliva and serum measurements of T in response to exercise amongst aging men.
In conclusion , postural tasks are associated with center of pressure spatial patterns and are similar in young and elderly healthy volunteers.
In conclusion , presepsin concentrations increase with age and kidney dysfunction.
In conclusion , primary school children's motor learning is enhanced by external focus instructions compared to internal focus instructions.
In conclusion , prolongevity genes are activated by CAMKIV , the levels of which are influenced by rs10491334 , a SNP associated with human longevity.
In conclusion , proteomic analysis of subcutaneous adipose tissue reveals differences in the abundance of proteins in adipocytes isolated from young vs. old individuals.
In conclusion , PTX-3 and adiponectin showed similar associations with metabolic factors , whereas PTX-3 and hs-CRP showed opposite trends.
In conclusion , Rab1B and MMP9 are potential prognostic biomarkers and their combination significantly improves predictive power for survival and chemotherapy response in CRC patients.
In conclusion , recovery responses from rhythmic IHG appear independent of contraction and / or rest period frequency-duration relationships.
In conclusion , refractory acne can be the first sign of systemic illness including polycystic ovary syndrome.
In conclusion , regardless of the anatomical variants of the left-sided pulmonary veins , the mitral isthmus area is quite uniform in size.
In conclusion , resting state EEG makers are promising for large-scale , low-cost , fully noninvasive screening of elderly subjects at risk of AD.
In conclusion , results provided by the present study suggest the need to develop novel culture protocols able to preserve stem cell plasticity.
In conclusion , rosuvastatin is effective and safe for younger or elderly Chinese patients.
In conclusion , RPI at the femoral neck discriminated fracture cases from controls independent of BMD and traditional risk factors but dependent on location.
In conclusion , sarcopenia showed an association with insulin resistance , diabetes , and MS , in the non-obese population.
In conclusion , SEE-SV has good item-to-total correlation , satisfactory internal consistence and substantial test retest reliability.
In conclusion , several knowledge gaps exist on the relationship between drug use and vitamin D blood levels.
In conclusion , sex and exercise intensity influence the FMD response to acute aerobic exercise in older adults.
In conclusion , sex steroids modulate selective gender-related hypothalamic-pituitary adrenal-axis adaptations to cortisol feedback in unstressed humans.
In conclusion , SH-HCCs are considered to occur more frequently in metabolic syndrome patients.
In conclusion , short-term conversion to AD is predicted by single marker models to a comparable degree as by multimarker models in amnestic MCI subjects.
In conclusion , sleep problems are associated with subsequent disability retirement.
In conclusion , socioeconomic position is important for the development of adult food intake patterns.
In conclusion , spatial navigation , a known cognitive marker of early AD , may be distinguished from other cognitive functions.
In conclusion , statin treatment appears to have a negative effect on tendon matrix quality as seen by a reduced strength of the tendon constructs.
In conclusions , the age-adjusted CCI could predict mortality and had a good discriminative performance for predicting longer term outcomes in patients who underwent TMVr.
In conclusion , storage alters similarly the optical properties of the resin cements and feldspathic porcelain was more susceptible to cement color change after aging.
In conclusion subjects with a high amount of PA have more positive metabolic health parameters independent of CRF.
In conclusion , sufficient data exist to support the use of these pharmacological agents in men with primary osteoporosis.
In conclusion , suggestions are offered for the clinical application and for further developing the model.
In conclusion , sulcal width measures are better markers than the HV for identifying prodromal AD in patients aged < 65 years.
In conclusion , surgery rates were affected by changes in the population structure , but by other factors as well.
In conclusion , sustained epigenetic differences arise from early adulthood to old age and contribute to an increasing discordance of MZ twins during aging.
In conclusion , SWB , with high cognitive and emotional facets , was associated with EL in the healthy Rugao population.
In conclusion , THC appeared to be safe and well tolerated by healthy older individuals.
In conclusion , the A673T variant is rarer in Danes than other Nordic countries , thus precluding assessment of association with longevity or cognitive functioning.
In conclusion , the adrenal cortex consists of homogeneous zG-topped columns from birth to adolescence.
In conclusion , the aged bladder was associated with ischaemic and inflammatory alterations in comparison to the control group.
In conclusion , the age-dependent cerebral endothelial dysfunction is precocious in dyslipidemia and involves TXA₂ production that limits eNOS activity.
In conclusion , the age-level difference in hand grip power using relative loads depends more greatly on MVC than velocity in females.
In conclusion , the Coach2Move strategy can be considered acceptable in PT practice and showed potential benefits.
In conclusion , the cognitive status of ALS subjects is associated with different patterns of cortical atrophy.
In conclusion , the contemporary understanding of the aetiology and pathophysiology of DUA is limited.
In conclusion , the contribution of SV to cPP decreases with age.
In conclusion , the current prevalence of AF and AFL is high and is projected to increase considerably by @number@
In conclusion , the data suggest that endothelial cells regulate β-catenin activity in adrenocortical cells also via secretion of basic fibroblast growth factor.
In conclusion , the decline in SIRT7 in lung fibroblasts has a profibrotic effect , which is mediated by changes in Smad3 levels.
In conclusion , the development of memory CD4 differed in acute AdV and persistent CMV infections.
In conclusion , the DRANWS is a reliable and valid scale to measure well-being at work of ageing hospital nurses focusing on dignity and respect.
In conclusion , the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women , but not in men.
In conclusion , the ETOC enables characterizing the prevalence of olfactory impairment in young subjects and in normal and pathological aging.
In conclusion , the expressions of MMP-1 and @number@ are increased with aging.
In conclusion , the findings provide guidelines about the normal variation of functional fitness in older women from the southern region of Brazil.
In conclusion , the hearing thresholds of younger firefighters and rescuers were worse than expected by normal aging alone.
In conclusion , the increased iFC might be the initial manifestation of altered brain function preceding cognitive deficits.
In conclusion , the intima-media thickness is greater in diabetics , but the annual increase in the thickness is greater in hypertensive patients.
In conclusion , the mean percentage of total ventricle volume within the total brain volume was found to be @percent@.
In conclusion , the measurements confirm the high protein density and RI of some MLB interiors compared to adjacent cytoplasm.
In conclusion , the mtDNA C150T polymorphism could not present an accumulation in an elderly Han Chinese population.
In conclusion , the NA is systematically asymmetrical and dynamic in shape along the thoracic and lumbar spine.
In conclusion , the number of cases of SE in elderly patients in Thailand has been increasing annually.
In conclusion , the period prevalence of LTCF-acquired infections was higher in Taiwan than previous reports , but the incidence was similar.
In conclusion , the present data demonstrated that the E. coli genotoxin colibactin induces cellular senescence and subsequently propel bystander genotoxic and oncogenic effects.
In conclusion , the present method made it possible , for the first time , to study steroid profiling directly in tear fluid.
In conclusion , the present study demonstrates a correlation between mtDNACD4977 in the human hair shaft and the severity of hearing loss in presbycusis.
In conclusion , the present study provides compelling evidences that carbocysteine may contribute to control the inflammatory and senescence processes present in smokers.
In conclusion , the present study shows that aging is associated with a reduction of the IB phase recorded during an incremental exercise test.
In conclusion , the present study shows that young apoE4 targeted replacement mice are impaired in numerous hippocampus-related learning and memory tasks.
In conclusion , the present work demonstrates higher levels of DNA damage in untreated breast cancer patients than in healthy women.
In conclusion , the rate and onset of terminal decline varied somewhat across cognitive domains.
In conclusion , the rate of morbidity and mortality in elderly patients were similar to those observed in younger patients.
In conclusion , there are positive correlations between Alu hypomethylation in blood cells and several age-related phenotypes in bone and body fat.
In conclusion , there is consistency that SB is negatively associated with physical performance.
In conclusion , there was no decline in dynamic cerebral autoregulation and cerebrovascular CO2 reactivity with increasing age up to @number@ years.
In conclusion , the risk scores and HbA1c are useful to identify subjects with undiagnosed IPH , with better performance than IFG.
In conclusion , thermoresponsive nanogels are promising topical delivery systems for biomacromolecules.
In conclusion , these data support that the IL-6 @number@ C + carriers and MT2A @number@ G- carriers may be more advantageous for longevity.
In conclusion , these results demonstrate that ET-1 vasoconstrictor activity contributes , at least in part , to diminished endothelium-dependent vasodilatation in older men.
In conclusion , these results do not support the involvement of ERK1 / 2 in tau phosphorylation under physiological conditions.
In conclusion , these results indicate that after exposure to hypoxia , RBCs display a modification of their actin and cytoskeleton instability.
In conclusion , these results revealed a role for folic acid in the JAK-STAT and LTD signaling pathways which may be relevant to AD pathogenesis.
In conclusion , these results suggested that LAN exposure in home settings is significantly associated with subclinical carotid atherosclerosis in the general elderly population.
In conclusion these results suggest that DNA SB damage increases with age but not FPG-sensitive sites.
In conclusion , these SIRT1 gene polymorphisms are associated with high body fat and blood pressure in Japanese , especially in men.
In conclusion , the sRAGE levels decrease with age.
In conclusion , the steeper longitudinal increase of PWV in men than women led to the sex difference that expanded with advancing age.
In conclusion , the telomerase activity and telomere length can be used as a diagnostic as well as a predictive marker in RCC.
In conclusion , the use of many types of dietary supplements has increased over time , but the use of antioxidant supplements has declined.
In conclusion , the use of memantine was associated with improved cognitive performance after @number@ months of treatment in the presence of VDD at M6.
In conclusion , the various GFAP isoforms show differential transcript levels and are upregulated in a concerted manner in AD.
In conclusion , the visiting doctors should bear in mind that the background factor of the occurrence of DPC without family is patient's malignant tumors.
In conclusion , the WHO aging classification reflects the LC values age ranges and can be used to estimate age-related alterations of this parameter.
In conclusion , the Wii BB is shown to be a valid and reliable method to quantify CoP displacement in older adults.
In conclusion , this is the first study to demonstrate the ability of two amino acids ( leucine and citrulline ) to modulate muscle function.
In conclusion , this naturalistic study showed that adherence to quetiapine treatment was high , and treatment was effective in schizophrenia patients during long-term treatment.
In conclusion , this study does not support that the FTO SNP is associated with all-cause mortality independently of the adiposity phenotypes.
In conclusion , this study extends previous knowledge of the effects of adiposity by providing sex- and age-specific causal estimates on cardiovascular risk factors.
In conclusion , this study provides evidence that LAMA5 rs659822 regulates anthropometric and metabolic traits in elderly people.
In conclusion , this study suggested that epigenetic alterations could play a role in smoking-associated development of frailty.
In conclusion , this study suggests that smoking-related epigenetic alterations are closely correlated with smoking-induced OS.
In conclusion , this system is effective in improving lung transplantation opportunities and outcomes.
In conclusion , this work provides critical targets for therapeutic research on geriatric heart failure , infectious diseases and hip fracture.
In conclusion , transfer of high-quality embryos does not overcome the negative effect of active smoking on pregnancy rate in IVF treatment.
In conclusion , two-thirds R-CHOP chemotherapy is a promising treatment for elderly patients with B-cell NHL in terms of its efficacy and toxicity.
In conclusion , type @number@ diabetes was associated with cognitive dysfunction , especially in young adults.
In conclusion , undertreatment of allergic rhinitis in the elderly is a reality.
In conclusion , UR is prevalent in French adults and is associated with several different characteristics.
In conclusion , variability in the attentional response to coffee may be partly explained by genetic polymorphisms of adenosine and adrenergic receptors.
In conclusion , variability of handwriting can be sensitive in predicting the aging process.
In conclusion , we clearly demonstrate that pharmacologic or genetic inhibition of autophagy fails to elevate ubiquitinated proteins unless the proteasome is affected.
In conclusion , we confirmed that BIN1 and PICALM are genetic determinants of AD , whereas the potential involvement of EXOC3L2 requires further investigation.
In conclusion , we consider the role of some psychological factors in the regulation of the aging program.
In conclusion , we demonstrated a positive correlation between 25 ( OH ) D and testosterone , which showed similar seasonal variation in Korean men.
In conclusion , we demonstrate structural WM changes related to an elevated body weight , but with differences between men and women.
In conclusion , we demonstrate that age affects the inflammatory response to both influenza vaccination and infection.
In conclusion , we demonstrate that modulation of proteostasis is a distinct biological function of sAPPα and does not require surface-bound holo-APP.
In conclusion , we developed a novel neurophysiological strategy for effect evaluation of BoNT-A in glabellar muscles.
In conclusion , we did not find significant associations between GWAS SNPs of pigmentation or melanoma and the risk for PD.
In conclusion , we discovered the SOX2-LIN28 / let-7 pathway as a unique molecular mechanism governing NPC proliferation and neurogenic potential.
In conclusion , we established hKlotho overexpression and Tet-inducible hKlotho overexpression cell lines and porcine embryos cloned from these cell lines.
In conclusion we find little evidence that telomere length is a significant biomarker of normal aging in important cognitive and physical domains.
In conclusion , we for the first time demonstrated that XN treatment can induce paraptosis of leukemia cells through activation of p38 MAPK signaling.
In conclusion , we found SPAD and MBL deficiency in many elderly , and conjecture that at least the latter arises with age.
In conclusion , we have demonstrated a positive correlation between eHSP72 and IR.
In conclusion , we have shown that it is important to establish PTH reference values in a local reference population taking 25OHD status into account.
In conclusion , we highlight the therapeutic potential of targeting brain IR in AD and the main strategies to pursue this goal.
In conclusion , we identified an epigenetic signature of DS that sustains a link between developmental defects and disease phenotype , including segmental premature aging.
In conclusion , we identify the main collaborative partnership conditions and factors in AFC-QC.
In conclusion , we provide novel data on dietary sugar , fibre , and micronutrient intake within elite youth soccer players.
In conclusion , we suggest that aaptamine represents a novel and effective strategy for treatment and prevention of photoaging.
In conclusion , we suggest that inhibition of glycolysis may be a potentially effective strategy to target BCSCs.
In conclusion , we utilized a novel method that demonstrates the importance of genome-wide GxE interactions in explaining the variance of diabetes-related traits.
In conclusion , WHt ratio is the best anthropometric predictor of both TT and cFT in this group of healthy but symptomatic ageing men.
In conclusion , widespread changes in methylation patterns were found in ALS-affected co-twins , consistent with an epigenetic contribution to disease.
In conclusion , with increasing age , the magnitude of LV longitudinal strain at the basal level declines while the apical LV longitudinal strain increases.
In conclusion , β-actin , GAPDH , and α-tubulin may not be used for normalization in studies that include subjects with a large age difference.
Inconclusive results have been reported in clinical trials of rosiglitazone , an insulin sensitizer that also increases cardiovascular mortality risks.
In concordance , plasma CTx was lower ( @number@.5±0.3ng / ml versus @number@.7±0.1ng / ml , p = 0.028 ) in the alcohol group.
In conjunction analyses , bilateral BOLD signal in the dorsolateral PFC ( Brodmann's areas @number@ @number@ ) was present only in the KPT.
In conjunction , the previous findings suggest that LPS and R848 elicit changes in the expression of costimulatory molecules via triggering differential intracellular signaling pathways.
In conjunction with higher comorbidity rates among older patients urologists are facing new challenges in the treatment and care of patients with bladder cancer.
In CON , relationships between Glx / Cr and age , and Glx / NAA and fatigue score were inverse.
In consequence , aluminum-containing agents been used in many food processing steps and also in removal by flocculation of particulate organic matter from water.
In consequence , approaching the problem of frailty as one of the scaling of subcellular deficits has implications for understanding aging.
In consequence the participation of healthy osteocytes in crack-impeding mechanisms is impaired.
In consequence , understanding their interaction and co-occurrence can offer insight into pathophysiology , prevention , and management.
In consequence , we observed the vast reduction in expression of nucleo-cytoplasmic trafficking genes in senescent cells , when compared with those in young cells.
In consideration of the burden of premature death , closer monitoring of weight loss in mid-life is warranted.
In consideration of the heterogeneity of affected patients is presumable that there are different pathogenic mechanisms.
In consideration of the small effect sizes replication studies are needed to validate these results.
In consideration of the wishes of the patient and his family , he was allowed to go home.
In considering evaluations of two programs from opposite ends of the country , inferences can differ depending on the observer.
Inconsistencies in training options have led to fragmentation of how critical care services are provided to the US adult population.
Inconsistency was quantified by using the @date@ statistic , which tests the proportion of heterogeneity across studies.
Inconsistent application , reporting , and interpretation of gait outcomes currently preclude a prescriptive approach.
Inconsistent associations were reported for the majority of reviewed determinants in adults.
Inconsistent data are present about SOD activity in patients with schizophrenia.
Inconsistent with predictions , there was a significant interaction between stress and race such that increased stressful events predicted CD in Caucasians but not African-Americans.
Inconsistent with previous findings , the estimation method did not moderate the relationship between age and estimates of recollection and familiarity.
In contextual cuing , faster responses are made to repeated displays containing context-target associations than to novel displays without such covariances.
Incontinence control measures were applied only to @percent@ of the residents.
Incontinence is a particularly complex issue , but invariably includes bladder diary assessment and pelvic floor muscle training.
In contrary , PAI-1 expression increases during aging or Aβ deposition with its clusters surrounding amyloid plaques.
In contrast , activated CSF CD8 T cells during chronic HIV infection were associated with markers of neurological injury and microglial activation.
In contrast , activation in the ventrolateral prefrontal cortex increased with age.
In contrast , activation of the Wnt / β-catenin pathway was enhanced when klotho was silenced by inhibitory RNAs.
In contrast , acute myeloid leukemia ( AML ) has far greater mortality rate than the ALL and is most commonly affecting older adults.
In contrast , addressing heart disease and cancer separately would yield diminishing improvements in health and longevity by @number@ mainly due to competing risks.
In contrast , AdipoR2 appears to play a minor role in this pathological process.
In contrast , adult BMMSCs do not express SkM-associated genes after in vitro SkM differentiation nor engraft in vivo.
In contrast , African American race was significantly associated with the risk for several selected disorders and outcomes.
In contrast , age-BP associations became attenuated or negative after adjusting for baPWV.
In contrast , aged animals spent more time in front of the mirror.
In contrast , age exerts only a slight effect on the mechanical properties of both muscles during transition from lying to sitting position.
In contrast , age-independent individual differences in filtering were reflected primarily later in the retention interval.
In contrast , ageing did not affect spontaneous sarcoplasmic reticulum calcium release.
In contrast , aGENs were associated with the PRC2 signature independently of the directionality of gene expression changes.
In contrast , age-related decline did not differ between the three locomotion modes for off-road triathlon.
In contrast , age-related decreases in posterior activity manifest during operations involved in stimulus categorization , post-decision monitoring , and preparation for an upcoming event.
In contrast , age-related differences in working memory , processing speed , and vocabulary were not modulated by time of the day.
In contrast , aging is a purposeless quasi-program or , figuratively , a shadow of actual programs.
In contrast , a growing body of evidence suggests that lifelong bilingualism may delay the onset of clinical AD symptoms by several years.
In contrast , albuminuria strongly associated with all-cause mortality and CVD.
In contrast , all cognitive performances showed moderate to high influences by the unique environmental factors.
In contrast , all measures of pulmonary function and muscle strength showed modest influences from the unique environment ( 40-50% ) .
In contrast , all young mice survived infection , displaying weaker IL-17 induction and neutrophil activation.
In contrast , a lower plasma total antioxidant capacity presented a relation with the presence of diabetes and arterial hypertension.
In contrast , aMCI showed increased connectivity in ventral lateral and anterior prefrontal cortex , bilaterally.
In contrast , among First Nations people , women had a higher lifetime risk than men across all index ages.
In contrast , among individuals with CKD , interleukin-6 ( IL-6 ) was independently associated with IR.
In contrast , among older adults , neither Koreans nor Americans showed significant influences of context in their face emotion ratings.
In contrast , among younger ( aged 35-54 ) and middle-aged ( aged 55-64 ) participants , vagal recovery was not associated with EF.
In contrast , amyloid burden was associated with less cortical ( p = @number@ ) or hippocampal ( p = @number@ ) atrophy.
In contrast , angiotensin receptor blockers ( OR @number@ @percent@ CI : @number@ @date@ ) appeared to be protective factors against OH.
In contrast , antigen-specific T cell responses were not or only weakly associated with antibody concentrations.
In contrast , a perceived performance climate was related to external regulation and amotivation through the mediation of unpleasant / dysfunctional psychobiosocial states.
In contrast , APOE ε4 is associated with greater amyloid PET ( from age @number@ years onward ) , while sex is not.
In contrast , a positive correlation between t-Hcy and TPx in OP patients was demonstrated significantly , r = 0.52 , p < 0.029.
In contrast , AS101 treatment did not affect the peripheral populations of CD11b ( + ) monocytes and macrophages.
In contrast , at older ages , Sod2 deficiency delayed wound closure and reduced epidermal thickness , accompanied by epidermal stem cell exhaustion.
In contrast , at the peak of the response , old and adult T cells exhibited superimposable peptide sensitivity.
In contrast , average EC subjects exhaustively selected all features of a stimulus.
In contrast , a wide variety of functional classes of genes are downregulated with age , often including tissue-specific genes.
In contrast , axial diffusion ( AD ) and grey matter ( GM ) densities did not show any significant correlation with IIV.
In contrast , Aβ 1-40 and Aβ 1-42 did not prevent replication of the non-enveloped human adenovirus.
In contrast , baseline synaptic connectivity strengths were consistently strong over the decades.
In contrast , blocking forward trafficking by brefeldin A prevented the effect with mKL but not with sKL.
In contrast , blood pressure and telomere length were not related to subjective age.
In contrast , Bmi1 overexpression in the heart protects from hypertrophic stimuli.
In contrast , both age groups were sensitive to the size of the neighborhood of similar-sounding words.
In contrast , both tau and p-tau interacted with CR , indicating that CR was more protective at lower levels of tau and p-tau.
In contrast , by visual assessment there was no white matter abnormality either on T2-weighted or diffusion-weighted images.
In contrast , cancer cells and senescent cells are resistant to PCD , enabling them to increase in abundance during aging.
In contrast , cardiac function was significantly declined in ( @number@ ) Fe ion-irradiated mice at @number@ and @number@ months but recovered at @number@ months.
In contrast , cardiac regeneration is very limited in adult humans.
In contrast , carotid intima-media thickness ( CIMT ) scanning protocols can detect atherosclerotic disease in early and asymptomatic stages.
In contrast , cells bearing the long isoform had significantly less BLIMP1 and XBP1 mRNA and , for human pre-B cells , remained CD138 negative.
In contrast , changes in these factors did not influence UUI.
In contrast , children aged @number@ and @number@ years remembered fewer than @percent@ of the early-life events.
In contrast , CH ingestion did not influence on MMP9 activity.
In contrast , combined FSS magnitude and frequency abnormalities essentially maintained valvular homeostasis.
In contrast , commitment did not emerge as a statistically significant predictor of caregiver depression.
In contrast , connectivity between the bilateral parahippocampal gyri was decreased in adults compared to children.
In contrast , constant rise was observed in rural women.
In contrast , control groups displayed volume decrements consistent with longitudinal estimates of age-related decline.
In contrast , cortical surface is larger in more intelligent children at the age of @number@
In contrast , CRP was not associated with LTL.
In contrast , CR rats were found to have significantly higher FoxO6 activities and maintained redox balance.
In contrast , CT nasal to the fovea in relationship to SFCT decreased with older age.
In contrast , decreased insulin signaling and / or mild insulin resistance paradoxically extends maximal lifespan in various genetic animal models of longevity.
In contrast , degenerated OA tissue showed the broadest distribution without prominent peaks indicative of substantially increased mechanical heterogeneity in the ECM.
In contrast , deletion of mIndy completely prevented the stimulating effect of IL-6 on citrate uptake and reduced hepatic lipogenesis.
In contrast , delta oscillations were present at higher levels than theta in both age groups.
In contrast , detoxification of reactive oxygen species and reactive nitrogen species can protect neurons.
In contrast , distal bone geometry appeared largely to be conserved in both tibia and fibula.
In contrast , during the no-vision trials , age-associated differences in movement error and variability were ameliorated.
In contrast , EC senescence was exacerbated by miR-34a overexpression.
In contrast , EFA yielded a 3-factor solution and test items cross-loaded onto a number of factors with no clear pattern of underlying cognitive domains.
In contrast , effector CD4 + T-cell subsets in older adults share similar phenotypic and functional characteristics with those from young adults.
In contrast , elderly adults showed significantly lower trunk co-activation than the young and middle-aged adults ( p < @number@ ) .
In contrast , elderly women who participated in household chores and family care activities expressed a negative life satisfaction.
In contrast , emerging evidence suggests that aging and disease-linked environmental risk factors exacerbate nitrosative stress via excessive production of NO.
In contrast , emotion does not improve their performances in the binding condition.
In contrast , endogenous functions and substrates of FMOs are less well understood.
In contrast , environmental influences were of substantial importance ( 55%-88% ) for rate of change of the hearing threshold over the 18-year period.
In contrast , excessive NO production has been related to global haemodynamic instability.
In contrast , executive functions were not affected.
In contrast , experimental and clinical data on the effect of ventricular fibrotic processes in the pathogenesis of AF and its complications are controversial.
In contrast , expression of the CD95 receptor was increased in aMCI and mAD.
In contrast , expression of TLR1-6 , TLR8 , MyD88 , and TRIF mRNA displayed no significant changes in the different phases of brain development.
In contrast , EZP in adults varied with several factors , including absorbed zinc , and was statistically smaller in zinc-deprived individuals.
In contrast , fat depot changes were only observed in severe COPD.
In contrast , FBF responses to ACh were not significantly altered by ET ( A ) blockade in the young men.
In contrast , fertility was associated with mortality.
In contrast , few VENs expressed markers associated with callosal or corticothalamic projections.
In contrast , for cutaneous squamous cell carcinomas , the relationship is reversed with higher risk in individuals with shorter telomeres.
In contrast , for nonwords , older participants performed equally worse than young participants on item and associative tests.
In contrast , for older adults who learned via map study there were no significant differences between forward and reverse directions.
In contrast , for sexual symptoms , there was a significant difference in the impact in older women for all grades of severity.
In contrast , for the ALC group , this relation was specific to the nonverbal EF measures.
In contrast , frailty by SOF index was not related to mortality.
In contrast , frailty by the SOF index was not correlated with hospitalization ( OR = @number@ @percent@ CI @number@.68-3.01 ) .
In contrast , GAGs did not induce aggregation of wildtype Fas1-4 , suggesting that the finding might be specific for lattice corneal dystrophy mutants.
In contrast , gait speed was unaffected in both cross-sectional and longitudinal comparisons.
In contrast , gay / bisexual men displayed lower overall cortisol concentrations throughout testing compared with heterosexual men.
In contrast , GBA-PD patients had a significantly younger age at onset and higher Unified Parkinson's Disease Rating Scale scores than LRRK2-PD and IPD patients.
In contrast , GDM-exposed ECFCs showed no change in p38MAPK activation under equivalent conditions.
In contrast , generalization was spared in all but the oldest adult group , likely reflecting preserved medial temporal lobe function until advanced old age.
In contrast , handgrip did not provide increments in the explained variance.
In contrast , HDAC1 inhibits HSF1 in a deacetylase-independent manner.
In contrast , HDL from patients with AD-only was not different in concentration , modifications , or function from HDL of healthy age-matched donors.
In contrast , heavy eye syndrome , also called myopic strabismus fixus , is characterized by profound esotropia and hypotropia with the eyeball fixed nasally.
In contrast , hemoglobin A1c levels were not significantly improved by the dietary intervention.
In contrast , high active APOE-e4 non-carriers had fewer depressive symptoms than low active APOE-e4 non-carriers.
In contrast , higher household income at baseline was associated with a higher level of BMI but similar rates of decline over time.
In contrast , higher levels of total cholesterol corresponded with increased accuracy in verbal working memory.
In contrast , high levels of CRP were not accompanied by short LTL in this cohort of older adults.
In contrast , high mean QOL was associated with higher social interaction ( P < @number@ ) .
In contrast , hippocampal activity in both older and younger adults was greater in higher- relative to lower-association trials.
In contrast I consider the positive role of epigenetic mechanisms in evolution because they provide organisms with opportunities for rapid adaptive change.
In contrast , I discuss that men age faster.
In contrast , if estrogens are administered during a critical period near the time of cessation of ovarian function , they will exert beneficial effects.
In contrast , in aged DCs , LiCl reduced the secretion of TNF-α and IL-6 in LPS stimulated DCs but did not increase IL-10.
In contrast , in children there was only feeble evidence for a trend towards enlarged dual-task costs.
In contrast , in children these processes dissociated.
In contrast , increases of ovary cancer in rural areas appeared in virtually all age groups.
In contrast , increasing the concentrations of CELF1 inhibited formation of the [ HuR / Myc mRNA ] complex.
In contrast , increasing white-matter incoherence with age appears to be nongenetic.
In contrast , independent of CL , a homotypic trans-OPA1 interaction mediates membrane tethering , thereby supporting the cristae structure.
In contrast , individuals who regressed from prediabetes to NGT increased both insulin resistance and beta cell function ( p < @number@ ) .
In contrast , in Experiment @number@ the participants explored the shape of small ( @number@ cm diameter ) surfaces with a single finger.
In contrast , in Experiments @number@ and @number@ we observed an age-related item-context binding deficit regardless of the level of concurrent load.
In contrast , inferior / superior visual hemifield asymmetries , with a direct ecological meaning , were found for both spatiotemporal frequency channels.
In contrast , in-firm training significantly raises the participants ' likelihood of finding regular jobs and of being independent of unemployment benefit receipt.
In contrast , in individuals with AD , selective associations were found between hippocampal volume and tissue contrast in temporal and limbic tissue.
In contrast , in myofibroblastic HSCs in fibrotic liver , many MMP genes are silenced into an epigenetically nonpermissive state.
In contrast , in old age this balance is poorly efficient compromising cellular homeostasis.
In contrast , in older adults , P3b amplitudes were more evenly distributed across the scalp and did not differ between context conditions.
In contrast , in older patients , the risk of over-diagnosis from using only sulcal enlargement is important.
In contrast , insulin resistance in lean individuals associated with higher risk of total and CVD mortality.
In contrast , insulin signaling in Drosophila and Caenorhabditis elegans directly regulates oocyte growth and maturation.
In contrast , in the elderly group , real stimulation improved performance compared to sham but bihemispheric tDCS was more efficient than unilateral stimulation.
In contrast , in the healthy aging , processing speed was negatively correlated with an increased oxygen desaturation index and the arousal index.
In contrast , in the read encoding condition , there was no group difference in recollection , but familiarity was impaired in the PD group.
In contrast , in young adults no difference was observed between high- and low-span individuals , whether in terms of their means or IIV.
In contrast , it decreased to < 0.30 , the lowest , at 1-2 years old.
In contrast , it reduced the activity of β-secretase and the level of secreted Aβ.
In contrast , its association with waist circumference markedly decreased.
In contrast , JH2O2 increased during complex-I supported leak respiration with insulin after exercise compared with resting conditions ( P < 0.05 ) .
In contrast , knockdown of Cbln4 gene in cultured neurons was followed by a large reduction of GABAergic connections.
In contrast , knockdown of endogenous CHIP results in the stabilization of cytoplasmic hTERT.
In contrast , knowledge of the pathological processes involved in ARHL remains very limited.
In contrast , large centromeric and pericentromeric satellite repeat clusters extensively dissociate from nucleoli in senescent cells.
In contrast , large target location shifts can lead to slow , voluntary adjustments.
In contrast , latent change score analyses showed longitudinal declines in axial diffusivity in association and projection fibers and increases in anterior commissural fibers.
In contrast , latent CMV infection triggered a shift from early to late differentiated CD4⁺ and CD8⁺ T cells in patients and controls.
In contrast , layer-specific LV longitudinal strain remains unchanged with aging.
In contrast , left frontal cognitive ERP patterns differentiated subjects with aMCI from NC.
In contrast , levels of 5fC and 5caC were significantly ( p < @number@ ) decreased in the HPG of PCAD and LAD subjects.
In contrast , life satisfaction appears to remain consistent , or perhaps decline across midlife before rebounding in old age.
In contrast , lipofuscin deposition was observed in neurons of the dentate nucleus.
In contrast , long-term culture associated changes were very consistent in fibroblasts and MSC.
In contrast , long-term FR had no effect on the mitochondrial activity in NSCs.
In contrast , low cortical metabolic activity in bilateral medial frontal cortex was associated with poor insight.
In contrast , low-dose irradiation resulted in residual γН2АХ foci still present at @number@ h.
In contrast , low-performing older adults benefited more from directed instruction of the strategy.
In contrast , low PRKCB levels were found in CA2 pyramidal neurons , and MAPK1 levels were elevated in controls and intermediate AD stages.
In contrast , lung triacylglycerol content was reduced while there was no change in lung fatty acid synthesis.
In contrast , making a tool following demonstration was easy for even the youngest children.
In contrast , many endogenous damage-associated molecular patterns ( DAMPs ) accumulate during ageing.
In contrast , Masters athletes showed younger Modelflow aortic ages than their chronological ages.
In contrast , men working in @number@ were less likely to be caregiving in @number@ whereas caregiving was not related to subsequent employment status.
In contrast , metformin improves reproductive function when started at any age.
In contrast , MiDAS is RAD52 dependent , and RAD52 is required for the timely recruitment of MUS81 and POLD3 to CFSs in early mitosis.
In contrast , middle-aged adaptors induced no aftereffects.
In contrast , mild DAT significantly affects predecisional information sampling.
In contrast , more negative age stereotypes were associated with a @percent@ greater likelihood of experiencing a hospitalization.
In contrast , mortality-related models provide limited support for positive cohort differences.
In contrast , muscle protein synthesis , DNA , and phospholipid synthesis were significantly higher in the older exercise groups than the younger sedentary group.
In contrast , nDNA-encoded bioenergetic genes have a low mutation rate.
In contrast , near visual acuity and cognition may positively share part of the unique environmental factors.
In contrast , Nefl ( N98S / + ) mice had a noticeable tremor , and most animals showed a hindlimb clasping phenotype.
In contrast , neither AChE activity nor concentration show a consistent , significant decrease during ageing in vitro.
In contrast , neither CortAUC nor Cortpeak correlated with HOMA-R in controls.
In contrast , neither increasing morbidity level nor higher individual health care costs influenced WTP significantly.
In contrast , neither markers of neurodegeneration nor WM integrity were altered in preclinical AD subjects.
In contrast , neoadjuvant treatment was more frequently applied in group @number@ ( p = 0.003 ) .
In contrast , NF-κB signaling pathway decreased with MHY908 treatment in insulin-treated cells.
In contrast , Ng was associated with regional brain atrophy only in individuals with Aβ pathology.
In contrast , no age-related functional connectivity changes were detected in somatosensory networks or during the motor paradigm.
In contrast , no association was found in oCIND.
In contrast , no association was found with GH-secreting pituitary tumors alone or with the sporadic counterpart of MEN2-component neoplasias.
In contrast , no between-group difference was observed for TL ( p = @number@ ) .
In contrast , no changes in Lypd6 levels were detected.
In contrast , no difference between groups was found in terms of the ability to access semantic knowledge about famous people.
In contrast , no difference between the stem cell types was detected for osteogenic differentiation based on Alizarin Red staining.
In contrast , no differences in HE or ∆Hb were observed during recovery ( p > 0.05 ) .
In contrast , no difference was observed in the intensity of the surface reflection or in the evenness of the subsurface reflection.
In contrast , no gender differences were found in cognitive or visuomotor functioning.
In contrast , no immunoreactivity to D-β-Asp-containing proteins was seen in pterygium-free specimens.
In contrast , no meaningful relationship was observed between the level of Prx @number@ expression and DFS in the adenocarcinoma subgroup.
In contrast , no measures were significant for subjects who received NSAIDs.
In contrast , no significant differences were found between younger and older healthy subjects.
In contrast , no significant effect was found for cortical excitability ( p = @number@ ) .
In contrast , no significant relationship was found between PTA ( high ) and cognition in any of the cohorts.
In contrast , NOS-induced reductions in retrograde shear rate were similar between groups.
In contrast , obesity is positively associated with RBC folate.
In contrast , older adults and children showed composite effects for both faces and watches , although the effects for faces were larger.
In contrast , older adults failed to show facilitation effects from either colorized-texturized or scene-primed items.
In contrast , older adults showed a relative increase in accuracy for competitors relative to young adults.
In contrast , older adults showed faster responses in cued conditions but exhibited more errors.
In contrast , older age was associated with less of a decrease in PA when exposed to recent stressors or with more severe recent stressors.
In contrast , older individuals with Aβ deposition showed no such increased task-related network connectivity , but did display increased regional activity unassociated with performance.
In contrast , older Mexican Americans who believe that it is important to suffer in silence tend to rate their health less favorably.
In contrast , older runners did not present a distal-to-proximal lower extremity joint moment redistribution.
In contrast , old Tg2576 mice showed decreased leptin receptors levels.
In contrast , only about @percent@ of participants were consistent TMS extremes at two or more visits.
In contrast , only high-sensitive C-reactive protein level was associated with the FTO risk allele in the obese subjects.
In contrast , only @percent@ described that they would have strongly agreed or agreed to this statement upon first arriving to the US.
In contrast , orienting improved over the course of the ANT and alerting showed a trend , though insignificant , that was consistent with learning.
In contrast , others have found an elevation of iron in SN in pre-clinical stages.
In contrast , other synaptically connected elements of the MTL did not exhibit size correlations.
In contrast , other traditional measures of CVD severity ( LVEF and angina pectoris ) were not independently predictive of subsequent functional status.
In contrast , overexpression of hTERT suppressed some of the defects caused by hStn1 knockdown suggesting that telomerase can partially compensate for hStn1 loss.
In contrast , [ oxyHb ] only continued to increase in the adult group.
In contrast , p75 ( NTR ) protein cortical levels were stable but increased in the hippocampus of aged 3xTg-AD mice.
In contrast , PA dynamics refer to short-term changes in PA that unfold over time.
In contrast , pain tolerance thresholds did not show substantial age-related changes.
In contrast , patients who did not undergo LTx experienced a further increase in LV mass.
In contrast , peak relaxation rate was markedly faster in men than women and slowed with age in men but not women.
In contrast , pepsinogen I , a known serologic marker of gastric atrophy , was not associated with NCGA in this population.
In contrast , perception of control was found to mediate the relationship between optimism and psychological well-being , but not subjective wellbeing.
In contrast , perceptual discriminability is not correlated with the amplitude of response in face-selective regions or of responses of object-selective regions.
In contrast , peri / postmenopausal subjects had ORs around unity for the same exposures.
In contrast , Pin1 is down-regulated or inactivated by multiple mechanisms in AD brains.
In contrast , place of residence did not increase the consumption of psychotropic drugs.
In contrast , positive affect and life satisfaction only gained in importance with advancing age for higher educated individuals.
In contrast , positivity emerged regardless of health status for decisions that were unrelated to health.
In contrast , postural adaptation to visual search was similar between groups in the AP direction.
In contrast , pretreatment with gefitinib and anti-HB-EGF antibody did not block both the phosphorylation and internalization of EGFR.
In contrast , prior selection of HFB and LFB did not affect the performance of 30-day-old animals in the EPM and novelty-induced USVs.
In contrast , pyramidal somal and nuclear volume were both negatively correlated and linearly associated with age in regression analyses.
In contrast , Q3GA increased BrdU-positive cell proliferation , Akt phosphorylation , and cyclin D1 expression.
In contrast , Rawson and Touron ( @number@ ) demonstrated a relatively rapid shift to memory-based processing in the context of a reading task.
In contrast , RBC folate increased incrementally with BMI.
In contrast , recruitment of FEN1 was highly enriched at sites of DNA damage within active chromatin in a PCNA- and transcription activation-dependent manner.
In contrast , reduced expression of aromatase was not reversed by estradiol.
In contrast , reduced glutathione / oxidized glutathione ratio and glucose-6-phosphate dehydrogenase activity were decreased upon PTX treatment.
In contrast , reduction of FKBP51 renders cells more sensitive to mTORC2 inhibition.
In contrast , regular aerobic exercise protects against the development of large elastic artery stiffness and vascular endothelial dysfunction with advancing age.
In contrast , results for monkeys compared with humans show significant interspecies differences in cortical thickness patterns in the frontal and the inferior temporal regions.
In contrast , results supported a shared prediction from the Grandmother Hypothesis and the Embodied Capital Model.
In contrast , retirement confidence is positively associated with both parents being deceased.
In contrast , RG chromatic sensitivity improves with higher levels of MPOD.
In contrast , RNAi suppression of sortilin results in decreased BACE1-mediated cleavage of APP.
In contrast , rs1344706 was not related to alerting and orienting.
In contrast , satellite cells and myonuclei may undergo apoptosis during muscle atrophy , although it is debated whether myonuclear loss occurs in atrophying muscle.
In contrast , SCE frequencies were significantly elevated in BLM-deficient cells irrespective of genome location.
In contrast , secretion of NGFβ was significantly lower and elongation of C-fibers was not observed in the Iso group.
In contrast , sequences-specific knowledge decreased in the elderly group independently of the delay.
In contrast , sex-related memory differences may be a better proxy.
In contrast , shorter LTL was weakly associated with decreased mortality hazard in AfAm.
In contrast , significant negative correlations of some ROS and HSP70 characteriscics were found for neutrophils from young people and nonagenarians.
In contrast , single-turnover rates of DNA unwinding by DDX11 and UvrD helicases were only modestly affected by the cPu lesion in the translocating strand.
In contrast , slower RT speed was associated with poorer episodic memory in general , but unrelated to the amount of forgetting.
In contrast , social network diversity was not independently related to future subjective well-being.
In contrast , SOD levels were decreased when compared to the initial levels ( P = @number@ ) .
In contrast , static face processing is poorer and more image-dependent in older adults.
In contrast , stereological analysis showed a gradual increase of the collagen and elastic system fibers relative frequencies , proportionally to SAHS seriousness.
In contrast , strong cardiac knockdown of ilk or ILK-associated genes can severely compromise cardiac integrity , including cardiomyocyte adhesion and overall heart function.
In contrast , studies of FTLD have shown a limited performance of first-generation PET probes in capturing non-AD-type tau lesions.
In contrast , studies on plasma Aβ40 and Aβ42 concentrations have yielded contradictory results.
In contrast , super-induction of the inflammation activity leads to weight loss and malnutrition in cancer cachexia.
In contrast sustained juiciness increased with increased age.
In contrast , sway area and medial-lateral sway velocity did not change between the two instructed focus sessions.
In contrast , tau-targeted drugs have been developed and have entered clinical trials.
In contrast , TBS values were rather different.
In contrast , TEs are effectively silenced in the germ line by the Piwi-piRNA system.
In contrast , the absorption of tetra / pentapeptides was not affected by aging.
In contrast , the Agility test revealed a poor concurrent validity.
In contrast , the annual cost of brain disease in the U.S. is $ 600 billion , more than cardiovascular disease and cancer combined.
In contrast , the APOE-MAP interaction had no effect on the rate of decline in any of these domains of cognitive performance.
In contrast , the application process was significantly difficult for community rehabilitation users ( OR , @number@ : @percent@ CI , @number@ @date@ ) .
In contrast , the association between LTL and mortality weakens considerably ( by @percent@ ) after adjustment for inflammatory markers and homocysteine.
In contrast , the associations between age and volumes of CA3-DG and the entorhinal cortex were negative in mid-childhood and attenuated in later adulthood.
In contrast , the associations of own education and adult occupation with physical performance were generally not maintained after adjustment.
In contrast , the ATFP usually contained abundant elastic fibers and smooth muscle.
In contrast , the authors could not find α-synuclein pathology in two SCA2 cases without Parkinsonism.
In contrast , the balance between aging and tumorigenesis at a higher level ( homeostatic-balance ) may benefit the organism with tumor-free longevity.
In contrast , the Behavioral Dyscontrol factor did not show specific neurobiologic correlates.
In contrast , the bone mass differences in the radial shaft between girls and mothers and mothers and grandmothers were relatively uniform.
In contrast , the breadth of the pertussis-directed CD4 ( + ) T cell response seemed dependent on age and closeness to infection.
In contrast , the Ca and P contents in the 70s were significantly higher in women than in men.
In contrast , the catabolic fragments of decorin are present in adult skin , but are virtually absent from fetal skin.
In contrast , the CG showed progressive decline.
In contrast , the color-shape task exhibited an aging-related increase in costs only in mixing errors.
In contrast , the constantly increasing subpopulation of aged patients causes a clinical need for effective and safe ( dermatological ) treatment.
In contrast , the consumption of meat and freshwater fish were less related to longevity.
In contrast , the corresponding aHRs were relatively homogeneous for women ( @number@ and @number@ ) .
In contrast , the curvature variability was significantly greater in the young than in the aged subjects.
In contrast , the CV effects are largely COX-2-dependent effects , unrelated to COX-2 selectivity but are dose dependent.
In contrast , the daf-16 / FOXO transcription factor is only partially required for the effects on dauer formation and not required for increased longevity.
In contrast , the data are conflicting for posthospital discharge CGA programs , outpatient CGA consultation , and CGA-based inpatient geriatric consultation services.
In contrast , the density of type II Dnmt3a immunoreactive cells showed an age-related reduction , without significant effects of both CR and SOD.
In contrast , the eye fissure frames of classical artists ' mothers ' portraits were significantly wider than those of beautiful younger women.
In contrast , the gastrointestinal tract was less frequently affected in EBV sBL ( P = 0.024 ) .
In contrast , the hippocampus showed increased activity during both encoding and retrieval , which was not related to these variables.
In contrast , the H reflex amplitude did not change with the cognitive load.
In contrast , the incidence of cataract surgery was considerably lower in this Chinese population.
In contrast , the indicators of the AMS showed incomplete conformity to the subgroups of the JAMQ.
In contrast , the intensity of immunostaining of Cu / Zn-SOD , Mn-SOD and catalase was not different between the two areas.
In contrast , the lowest dose tested effectively blocked NV and caused regression of existing NV , without appreciably affecting vasculogenesis or retinal revascularization.
In contrast , the lumbosacral spine compensates in such a manner so as to maintain the sagittal balance.
In contrast , the Lyme disease-negative control group had only @percent@ of samples seropositive for B. microti.
In contrast , the mean and sum of entropy were significantly decreased in the younger group compared with the middle-aged and elderly groups.
In contrast , the mechanisms by which prolonged caloric restriction confers cardioprotection seem more complicated.
In contrast , the most common trajectory among the living was a flat low HSC.
In contrast , the multigenerational living arrangements were related to greater social support from extended family and higher extended family satisfaction.
In contrast , the mutation did not remove GMQ antagonism but only changed the guanidine compound's potency within the human GABA-A ρ1 receptor.
In contrast , the N15D mutant displays all the detrimental effects related to deamidation.
In contrast , the NIRS oxyhaemoglobin , deoxyhaemoglobin and microvascular oxygenation indices were not significantly different between the groups ( P > 0.05 ) .
In contrast , the non-carriers demonstrated a gradual increase in activation over the 5-year period.
In contrast , the Nrf2 activator CDDO-Im restored complement gene expression in RPE cells exposed to CSE.
In contrast , the @number@ other missense variants of uncertain significance showed normal mRNA expression and no abnormalities in protein function.
In contrast , the older adults needed a much longer surface point lifetime of approximately @number@ views in order to reliably perform the same task.
In contrast , the older adults showed a more specific and shorter-lived slowing.
In contrast , the older group showed a nonsignificant difference in the position of the midbrow and the lateral brow.
In contrast , the overall analyses with the total sample did not reveal any significant within-subject effects Time.
In contrast , the physical activity environment was positively associated with leisure activity among only urban adults.
In contrast , the p.R1664Q variant exhibited loss of function and failed to develop a neurodegenerative phenotype.
In contrast , the presence of these objects might also lead to distraction in dementia and MCI.
In contrast , the prevalence of overweight and obesity did not differ between the two groups.
In contrast , the proportion suffering from faecal incontinence remained stable at @percent@ in @number@ and @percent@ in @number@
In contrast , the protective effects of using cell phones persisted among women , even net of all controls.
In contrast , there is evidence that cortisol can act as a negative transcriptional regulator of RACK1 expression.
In contrast , there is no association between sympathetic nerve activity and peripheral resistance in women before menopause , yet a positive association after menopause.
In contrast , the resonance characteristics of oscillatory activity are dependent on the integrity and structure of long range cortical connections.
In contrast , there was a positive impact of the intervention on specific aspects of cognitive function.
In contrast , there was a sharp decline in saturated and trans fat content of large French fries per @number@ kcal.
In contrast , there was no association between total daily energy expenditure and FI34.
In contrast , there was no significant effect of age on DA synthesis capacity.
In contrast , there was no significant trend of either of these cell populations with age in the blood.
In contrast , there was not a significant age-related decline when the two tasks were presented sequentially.
In contrast , there was up regulation of the same gene ( s ) in MCI subjects compared to AD and ND cases.
In contrast , there were decreases in all-cause mortality rates across each age group.
In contrast , there were fewer significant associations between episodic memory and FA.
In contrast , there were no age differences in empathic accuracy for positive feelings and for thoughts accompanying experiences of positive affect.
In contrast , there were no interaction effects of parenting status , age , and negative parenting experience among fathers.
In contrast , there were no significant performance gains in the left hand for the older group ( P = @number@ ) .
In contrast , there were only small areas of cortical thinning inversely associated with DWMH , which were distributed in medial frontal and lingual gyrus.
In contrast , the RPs may not be affected in studies that include muscle wasting and differences in muscle fiber type.
In contrast , these cells showed a delayed and very limited response in non-regenerative froglets.
In contrast , the sepsis mortality among neonates and the elderly ( ≥75 years ) was obviously higher than national averages.
In contrast , the standard AVP assay was unaffected ( @percent@ interpretable ) and urine acidity predicted specimens with low OT concentrations.
In contrast , the truncated form , called TRX80 , produced by macrophages induces upregulation of proinflammatory cytokines.
In contrast , the two groups did not differ with regard to either paroxysmal or chronic atrial fibrillation.
In contrast , the variance explained by WAT was higher for verbal fluency and the Trail-Making Test in areas with high SES.
In contrast , the visceral fat area showed an age-dependent increase in both sexes.
In contrast , this subjective skin feeling after application in participants at age @number@ and older did not differ much.
In contrast , this transport was enhanced in SMAP2 ( - / - ) cells characterized by increased levels of the activated form of Arf.
In contrast , thromboxane A₂ ( TXA₂ ) , a potent pro-oxidant and pro-inflammatory endogenous vasoconstrictor , is associated with eNOS dysfunction.
In contrast , time intervals reflecting systolic function showed less circadian variation and less worsening with age.
In contrast , tissues that express higher telomerase activity such as umbilical cord blood and placenta appear comparatively more affected by ART.
In contrast to age-related formulas , however , the ultrasonographically determined MTDSA was not significantly different from the correct ETT.
In contrast to childhood ALL , survival for adults with ALL is poor.
In contrast to clear cell RCC , there is no consensual protocol using targeted therapy for metastatic pRCC.
In contrast to common perceptions , none of the participants felt that aging had negatively impacted their own sexuality.
In contrast to current approaches , caring for elderly individuals in their homes based on a digital technology infrastructure could be effective and cost-saving.
In contrast to every other group , old untrained subjects failed to upregulate CAT postexercise.
In contrast to higher estimates of prevalence based solely on numeric values , the syndromic prevalence of LOH is only @percent@.
In contrast to human and mouse , the zebrafish genome contains four collagen XXVIII genes , col28a1a and -b , and col28a2a and -b.
In contrast to IGFBP-1 , IGFBP-2 was present in significantly greater quantities in complexes with α2M dimer than α2M monomer in older individuals.
In contrast to leptin , whose action is attenuated in obesity , the ability of IL-6 to suppress feeding is enhanced in obese mice.
In contrast to men , triglycerides were stable in ageing women.
In contrast to middle-aged ( 40-64 years ) HF patients , multiple cardiac , non-cardiac and geriatric syndrome co-morbidities are seen in elderly HF patients.
In contrast to most structures of the adult central nervous system , the hippocampus can rely on a form of plasticity known as neurogenesis.
In contrast to murine collagen XXVIII , the zebrafish orthologs are widely expressed and not only present in the nervous system.
In contrast to normal aging , the presence of amyloid increased apoE3 , whereas apoE4 was unchanged or decreased.
In contrast to other conditions linked to clonal haematopoiesis , the clonal signature of AA reflects its immune pathophysiology.
In contrast to other datasets and due to the continuous nature of the regression there is no need for data sub-categorization.
In contrast to p53 , Rb was not expressed in any senescence lesion.
In contrast to PMMA , no relevant heat is generated during the hardening process and there is no risk of embolism.
In contrast to postmitotic or short-lived somatic cells , tissue-specific stem cells must persist and function throughout life to ensure tissue homeostasis and repair.
In contrast to previous short-term effects , altered BOLD activations to self-referential criticism did not separate responder groups at follow-up.
In contrast to previous studies , accuracy did not differ between the preferred and non-preferred arms in either group.
In contrast to previous studies showing ptosis in PAP , relative upper eyelid retraction was seen in most of our treated eyes.
In contrast to results from investigations of younger workers , job strain was unrelated to alcohol misuse.
In contrast to sex , nonsexual intimacy is highly prevalent at older ages , especially among women.
In contrast , total brain volume correlated significantly with total score on the RBANS.
In contrast to the -13907 G and -13910 T SNPs , the -13915 G SNP was previously believed not to interact with Oct-1.
In contrast to the CT group and controls , the CRT group showed a steep decline of FA with age at assessment.
In contrast to the HC and nvMCI groups , svMCI patients did not show improvement in the executive network from the valid visual cue.
In contrast to the high number of available scales there is limited evidence supporting their measurement properties.
In contrast to the intra-species observation , this analysis revealed a significant negative correlation of plasma IGF-1 with body mass.
In contrast to their younger counterparts , elderly patients experience significantly higher mortality rates and complications after major trauma.
In contrast to the ossifying human thyroid cartilage , predominantly cartilage mineralization was observed in minipig and domestic pig thyroid cartilages.
In contrast to the other complexes , complex I was almost exclusively found assembled in supercomplexes in muscle mitochondria.
In contrast to the performance measures , differences in tactile experience were associated with differences in the subjective response to touch.
In contrast to the tree-based metrics , classical metrics were highly influenced by age-related changes in network density.
In contrast to the well-characterized starvation-induced autophagy , the regulation of selective autophagy is largely unknown.
In contrast to the young adults , learning was not superior in older adults who received full instructions compared with those who did not.
In contrast to this result , NET formation was slowly and gradually increased by SME liposomes , within 4h.
In contrast , trabecular bone volume is not altered in these mice.
In contrast , trabecular vBMD and microarchitecture showed linear association with age with significant deterioration observed throughout adulthood.
In contrast , transfection with nestin mutated at both phosphorylation sites ( Thr315 and Thr1299 ) did not enhance cell migration or invasion.
In contrast , treatment with a novel class of GSMs had no significant effect on these measures.
In contrast , treatment with exogenous Pot1a protein prevented telomeric DDR , which decreased stem cell activity and partially rejuvenated HSC activity.
In contrast Treg were negatively correlated to infection intensity in the older age group.
In contrast , tricarboxylic acid cycle enzyme transcript levels were unchanged and their metabolites were depleted.
In contrast , TSH declines until age @number@ and then increases slightly in both sexes.
In contrast , under non-diabetic conditions , DJ-1 expression increases in mouse and human islets during aging.
In contrast , unspecified PM tasks do not require responding in a particular order.
In contrast , use of NSAIDs was not substantially associated with the reductions in hallmark lesions of AD.
In contrast , using meta-analysis of human data , I find no such decline.
In contrast , variability in most other large-scale networks decreased linearly over the lifespan.
In contrast , very few DMRs distinguished regions of the cortex , limbic system and brain stem.
In contrast , VOR gain was not associated with any physical performance measure.
In contrast , we developed a paradigm which much more closely approximates real-life situations of information encoding.
In contrast , we did not observe any regulation of forkhead transcription factor ( FoxO ) target genes.
In contrast , we did not observe a significant effect of APOE ε4 on PHF-τ levels by disease stage in any region.
In contrast , we found a positive association of long-term beta blocker use and risk of stage IV CRC.
In contrast , we found decreased connectivity between the precuneus and other task-negative default regions and visual cortices.
In contrast , we found no evidence for age differences in value-related processing or age-related compensation for choices without delayed retrieval.
In contrast , well-being in older adults was unrelated to performance across a range of standardised memory tasks.
In contrast , we observed a reduction in the amount of mtDNA copy in both AD and CJD.
In contrast , when co-expressed with Tau , these PD-associated mutants destabilize microtubules with significantly higher potency than WT.
In contrast , whereas younger subjects recalled PMs as often as they recalled AMs , older subjects experienced PM twice as frequently.
In contrast , wild allele combination increases lung cancer risk for individuals over the age of @number@
In contrast , wild-type lamin A and lamin A mutants causing atypical Werner syndrome were able to bind to these molecules.
In contrast with decreasingly methylated ageCGs , increasingly methylated ageCGs are also generally further from CTCF binding sites and enriched within lamina associated domains.
In contrast with most developed countries , mortality due to ischemic heart disease ( IHD ) continues to rise in China.
In contrast with previous literature , the present program evaluation setup accounts for non-random selection bias and heterogeneous treatment effects.
In contrast , with the sharp needle technique , material was placed in multiple anatomic layers , from the periosteum to more superficial skin layers.
In contrast with young , elderly subjects failed to suppress irrelevant letters when attending faces.
In contrast , XN treatment resulted in LC3-II accumulation through blocking of autophagosome maturation.
In contrast , young adults ' AP sway increased during imagery relative to their baseline.
In contrast , young adults ' memory errors did not differ for the warning versus no-warning groups.
In contrast , young adults ' vividness ratings were more related , relative to older adults , to category representations in parietal cortex.
In contrast , young-old and old-old adults produced a larger N170 over the left hemisphere.
In contrast , young rats showed insulin-mediated TrkB / BDNF response , which paralleled with improved memory performance.
In contrast , youth with nonsevere disabilities had lower odds of regaining insurance and experienced longer durations of uninsurance compared to peers without disabilities.
In contrast , ΔDBP increased very slowly until @number@ years of age and then decreased similarly for those with and without the MetS.
In controls , aging was associated with a decline of @number@.6%-4.6% per decade in striatal binding.
In controls , neither NBV nor WMH was associated with CBF.
In controls , the posterior IFC showed more activity for syntactically complex sentences than simpler ones , as expected.
In control subjects , higher WMH was related to lower global cognitive function ( ρ = @number@ n = @number@ p = @number@ ) .
In COPD , this integrated approach has been effective in reducing exacerbations , improving quality of life , and even reducing costs.
In coping with these challenges , older adults focused on positive evaluations , reframing , acceptance , and adaptation.
Incorporate risk-reduction strategies during preoperative assessment.
Incorporate use of valid patient outcomes assessment tools in their practice to facilitate standardized outcomes reporting in the face-lift literature.
Incorporating contemporary obesity rates and population estimates , we calculated the number of persons living with symptomatic knee OA.
Incorporating its framework into the current medical education may enhance cross-cultural clinical encounters.
Incorporating pharmacoeconomic studies in phase III clinical trials for Alzheimer's disease presents a number of challenges.
Incorporating the caregiver's preferences and values into clinical decisions may improve outcomes among stroke survivors.
Incorporating these properties into a computational model leads to quantitatively similar results to the fMRI data.
Incorporation of cetyltrimethylammonium bromide or soyaethyl morpholinium ethosulfate , the cationic surfactant , converted zeta potential from a negative to a positive charge.
Incorporation of impaired cognitive function into routine preoperative risk assessment and decision making could be an important addition to traditional risk assessment strategies.
Incorporation of these criteria into computer-assisted order entry systems would increase their utilization in daily practice.
In cortex samples of the SAMP8 mice , decreased levels of protein carbonyl and protein-bound HNE were measured , indicating decreased oxidative stress.
In cosmetic and reconstructive procedures , maintenance of the anatomical relations of these landmarks ensures a pleasing postoperative appearance.
In cosmetic practices , various cosmeceuticals are applied before microneedling to enhance the therapeutic effects.
In countries dominated by Western philosophical thought , the cognitive domain has been privileged over other mental domains.
In countries such as the USA , China , and India , there may easily be over @number@ million repairs every year.
In courses where topics are sensitive or even considered taboo for discussion , it can be difficult to assess students ' deeper learning.
In Cox proportional hazards models , DM also predicted incident dementia in older age groups at baseline.
In cranial MRI scans of @number@ women aged 20-35 and @number@ women aged 65-80 relevant anatomical dimensions were measured.
Increased accumulation of NRF2 in cancers is strongly associated with the poor prognoses of cancer patients , including those with lung and breast cancers.
Increased activation of the inferior parietal region may offer a pathway through which CV risk increases risk for cognitive impairment.
Increased activity of the satiety hormone , cholecystokinin ( CCK ) , may be partly responsible.
Increased age and a pathologic electrocardiogram were predictors of carotid sinus syndrome.
Increased age , being married / partnered , and female sex were associated with high social support in the final model.
Increased age , BMI and HbA1c levels are risk factors for several non-communicable diseases.
Increased age detrimentally affects control of movement and stability , although the neural mechanisms underlying these deficits are not entirely understood.
Increased age , dialysis and late onset ( ≥ @number@ days from admission ) VAP were associated with increased incidence of resistance.
Increased age is a major risk factor for stroke incidence and post-ischemic mortality.
Increased age is closely related with aforementioned alterations.
Increased Akt ( Ser473 ) phosphorylation and induction of ROS by αTP occur in a wortmannin-sensitive manner , indicating the involvement of phosphatidylinositol kinases.
Increased amounts of 8-oxoguanine in the RNA , and decreased expression of MTH1 were also observed in the hippocampi of patients suffering from Alzheimer's disease.
Increased and decreased joint range of motion ( ROM ) are modifiable risk factors for musculoskeletal soft-tissue injuries.
Increased ankle strength in summer may be influenced by increased levels of outdoors activity over the summer months.
Increased arterial stiffness is closely associated with the progression of cardiovascular disease.
Increased attention to psychological measurement of personality and of cognitive ability using adaptive testing structures has also been shared across the studies.
Increased attention to suicidal ideation and risk assessment might be warranted during the diagnosis and treatment of these disorders.
Increased awareness of the available options to aid in determining cognitive function of the older adults is paramount when obtaining informed consent.
Increased Beclin-1 expression was significantly correlated with increased Gli2.
Increased bone fracture rates and reduced bone density are commonly observed in patients with AD , suggesting one or more common denominators between both disorders.
Increased brain iron content has been linked to neural degeneration and to age-related decline of cognitive and motor functions.
Increased brain iron levels may be a risk factor for age-related neurologic disorders.
Increased calcium intake is associated with increased bone mineral accretion rate up to a threshold level in all ethnic groups.
Increased capacity for early detection and treatment of HIV-associated cancer needs to be a new priority for programs in Africa.
Increased cell death and inflammatory responses could not be assigned to a single chemical fraction of the particles.
Increased central sympathetic nerve activity induced by local airway inflammation may be one possible mechanism.
Increased CHD risk does not appear to be a reason for lowering the upper thyrotropin reference limit.
Increased circulating white blood cell ( WBC ) count has been associated with cardiovascular ( CV ) diseases and frailty but there are discrepancies.
Increased cognitive task complexity resulted in greater slowing of gait : gait DTCs were least for the simplest conditions and greatest for the complex conditions.
Increased combined efforts from all levels of care and wider ranged multidisciplinary nutritional support need to be implemented.
Increased comfort and management ability was attributed to previous real-world experience and support from content experts in dealing with acutely ill children.
Increased connectivity showed no clinical correlation with migraine frequency or sensory sensitivity.
Increased constant pain was related to decreased chair stand test performance over @number@ years in women ( B = @number@ p = @number@ ) .
Increased C-reactive protein and interleukin-6 , coronary artery disease , body mass index , and alcohol consumption have also been associated with SBI.
Increased depressive symptomatology in carers was associated with being married , having offspring and caring for a patient with dementia and a co-morbid cardiovascular disease.
Increased DNA and chromosomal damage are linked to aging and age-related diseases like cardiovascular diseases , diabetes or cancer.
Increased dosage of genes located within the duplicated region probably cannot increase disease risk and disease severity without the contribution of additional risk factors.
Increased DTI rates in the thalamus correlated with progressive decline in global cognition in PD.
Increased erythrocyte DHA levels were associated with reduced telomere shortening ( r = @number@ P = @number@ ) in the DHA group.
Increased ESR , MPV and low HRVi indicate elevated sympathetic activity in RLS group.
Increased exposure to air pollution may also have played a role in driving the period effect.
Increased expression and activity of cathepsins , lysosomal cysteine proteases , during degeneration of the central nervous system is frequently reported.
Increased expression of cell cycle-related gene sets was associated with poor prognosis , and B-cell immunity-related gene sets were associated with good prognosis.
Increased expression of MMPs affected IVDD positively.
Increased expression of sirtuins lowers the risk of age-related diseases , while their role in the regulation of longevity is not firmly established.
Increased expression of type I and type III procollagen was demonstrated.
Increased fat mass and fat redistribution are commonly observed in aging populations worldwide.
Increased focus on specific domains of cognitive function is needed to improve our understanding of how benzodiazepine use influences cognition.
Increased frontal cortex activation during cognitive task performance is common in aging but remains poorly understood.
Increased gait variability might reflect a multisystem reduction and may be useful in identifying frailty.
Increased genetic knowledge will also identify potential therapeutic targets and could lead to the development of individualised medicine for patients with ALS.
Increased GLB1 stratifies better PSA-free survival in intermediate grade PCa ( @number@ ) .
Increased global amyloid-β was related to decline in verbal episodic memory , visual episodic memory , executive functioning , and fine motor processing speed.
Increased glutamate has also been found in depression , a disorder associated with increased inflammation.
Increased GM atrophy rates ( approximately @percent@ per year ) were observed in patients compared with controls.
Increased health optimism corresponded with enhanced functioning ; increased pessimism corresponded with decreased functioning.
Increased infections also occurred when older participants did not feel they had religious support from their congregations.
Increased inflammation was related to reduced tryptophan concentrations and increased kynurenine levels , suggestive of IDO-induced increased tryptophan catabolism.
Increased intellectual activities between waves did not substantially affect any domain of depressive symptoms.
Increased interference was found behaviorally in older volunteers.
Increased intermanual transfer was demonstrated in older subjects during feedforward learning , with no difference between groups during feedback learning.
Increased intima-media thickness is associated with the presence of other cardiovascular , cerebrovascular disease and the development of atherosclerosis in both adults and pediatric populations.
Increased intracellular potassium causes depolarization , and calcium influx through the voltage-dependent calcium channels occurs.
Increased investments in the health care of this population are needed regarding musculoskeletal and cardiorespiratory capacity.
Increased iron has been seen in the cerebral cortex in postmortem studies of neurodegenerative diseases and healthy aging.
Increased knowledge of how community-based services can better accommodate the care needs of solitary-living individuals with AD is essential.
Increased length and syntactic complexity negatively affected performance in both groups of speakers.
Increased levels of acyl-carnitines indicated an increased turnover of storage and membrane lipids for energy production.
Increased levels of advanced glycation end products ( AGEs ) in skeletal muscle tissue are observed with advancing age and in diabetes.
Increased levels of aquaporin-4 , indicative of edema , observed in regions of periventricular gliosis in human tissue were also replicated in our mouse model.
Increased levels of flavivirus activity were detected in western and northern Australia , which prompted public health action.
Increased levels of IL-1β were caused by the upregulation of caspase-1 activity and inflammasome activation.
Increased levels of pro-inflammatory markers and decreased levels of anti-inflammatory markers in the breast tissue can result in local inflammation.
Increased levels of protein oxidation have been associated with various biological consequences , including diseases and aging , in humans and other animal species.
Increased levels of TMEM106B alter lysosomal morphology and interfere with lysosomal degradation.
Increased levels of β2-MG were observed in the dementia group compared with the healthy advanced age group.
Increased life expectancy , ageing and the accumulation of chronic pathologies leads to a certain functional dependence.
Increased lipids and a \ "low \ " grade inflammation may contribute to TL shortening and consequently to premature ageing and increased morbidity in CS.
Increased local production of TGFβ1 is considered the inducing stimulus.
Increased lycopene intake may reduce prostate cancer progression , with a potential role for carotenoids at other cancer sites.
Increased MAO-B expression in astroglia has been observed adjacent to amyloid plaques in AD patient brains.
Increased mastery over @number@ weeks was also associated with greater reductions in depressive symptoms at follow-up , controlling for antidepressant strength and adherence.
Increased MDA and PC levels strongly support the increased oxidative damage in elderly subject than young subjects.
Increased methylation is associated with decreased semen quality , and sperm selected by density gradient centrifugation have less methylation.
Increased miR-181 was not detected in pre-pathological 3xTg-AD mice.
Increased morbidity and mortality have been associated with extreme heat events , particularly in temperate climates.
Increased mortality is seen in dialysis patients who are elderly , have significant comorbidities , and have poor functional status.
Increased mortality risk also extends to major and minor fractures , especially , in those over @number@ years.
Increased motivation and compliance proved to be beneficial for task performance , thereby potentially increasing the validity of the results.
Increased motor simulation may contribute to the amelioration in social functioning documented in adolescence and adulthood.
Increased mTORC1 activity caused decreased rate of degradation of internalized POS in the RPE.
Increased mTORC1 inhibits POS degradation and may further exacerbate lysosome dysfunction of aged RPE.
Increased muscle coactivation could be a necessary change to compensate for a deterioration in postural control accompanying healthy aging.
Increased muscle strength improves daily function and quality of life.
Increased neural variability may be related to the performance declines and increased behavioral variability that occur with aging.
Increased numtogenesis was observed with higher mortality.
Increased oral intake of iron in the neonatal period leads to a progressive age-related enhancement of dopaminergic neurodegeneration associated with paraquat neurotoxicity.
Increased OSA severity without obesity in very old patients needs to be confirmed and further studied.
Increased osmolarity induces ocular surface inflammation leading to disruption of both the quality and quantity of tears.
Increased outreach and education regarding early detection of lung cancer and smoking cessation are needed for this vulnerable and high-risk population.
Increased oxidative stress and misfolded protein formations , combined with impaired compensatory mechanisms , may promote neurodegenerative disorders with age.
Increased oxidative stress is a hallmark of every major neurodegenerative disease that has been studied.
Increased oxidative stress is one of the potential contributing factors to aging.
Increased oxidized low density lipoprotein ( ox-LDL ) in the sub-endothelium is the characteristic origin of atherogenesis.
Increased oxidized PTEN activated the mitogenic pathway through over-activated Akt.
Increased p16 ( INK4a ) expression , in the absence of telomere shortening , indicates that premature PT-ECFC aging results from stress-induced senescence.
Increased parental longevity was also associated with lower risk of physician-diagnosed memory disorder.
Increased patient age was found to accentuate these processes.
Increased patient safety requires interprofessional collaboration , now critical given rising healthcare costs and an aging population with complex and chronic conditions.
Increased PCr , increased beta NTP ( reflecting ATP ) and reduced pH may reflect altered energy production with healthy aging.
Increased physical activity and perceived health were the most reported perceived positive changes.
Increased physical activity levels have been shown to reduce the occurrence of many chronic diseases leading to reductions in the burden on the healthcare system.
Increased physical activity limited lean tissue loss in men but not in women.
Increased pineal calcifications and decreased pineal melatonin biosynthesis , both age related , support the notion of a pineal bio-organic timing mechanism.
Increased PK activity in AD is likely to contribute to increased BK release and may thereby influence cerebral blood flow and vascular permeability.
Increased plasma Aβ1-40 was associated with lower baseline hippocampal volume.
Increased plasma levels of inflammatory mediators increase the catabolic stimuli of the musculature , thereby causing a decrease in mass and muscular function.
Increased power in post stimulus gamma in the double peak group may be indicative of compensatory neural processing.
Increased prevalence of non-alcoholic fatty liver disease ( NAFLD ) is one of the consequences of the current obesity epidemic.
Increased proportion of non-contractile elements can be observed during aging by enhanced skeletal muscle echo intensity ( EI ) .
Increased proteolytic activity is a hallmark of several pathological processes , including neurodegeneration.
Increased public education about risk factors for the disease is also required.
Increased rates of amniocytes with SAHFs were observed among the trisomy samples compared to the control group.
Increased resistance in the trabecular meshwork ( TM ) , a filter-like structure essential to regulate AH outflow , may result in the impaired outflow.
Increased risks in people from Central and Eastern Europe can also be found.
Increased ROS levels have been observed in several hematopoietic malignancies including acute and chronic myeloid leukemias.
Increased ROS production was blocked by inhibition of PI3K or protein kinase C ( PKC ) or by NADPH oxidase activating in replicative senescent cells.
Increased ROS were detected by HBx.
Increased senescent cell burden in various tissues is a major contributor to aging and age-related diseases.
Increased severity of cognitive impairment was associated with greater motor impairment.
Increased sexual activity was associated with positive physical , social , and emotional health indicators.
Increased social activities between waves predicted higher positive affect and lower interpersonal difficulties scores at follow-up.
Increased specificity is reflected in studies of relationships between specific neuropsychological deficits , specific brain abnormalities , and antidepressant responsiveness.
Increased SSAO activity and expression have been detected in cerebrovascular tissue and plasma of AD patients , colocalizing with cerebrovascular amyloid-beta ( Aβ ) deposits.
Increased stratum corneum hydration and reduced TEWL may improve skin quality.
Increased surgical risk and paucity of symptoms in these patients sometimes result in a delay in surgical treatment.
Increased surveillance for diabetes has contributed to increased diabetes prevalence in higher-income countries.
Increased survivin accumulated both in the nucleus and cytoplasm and dissociated with condensed DNA and mitotic spindle at the metaphase.
Increased susceptibility to apoptosis may contribute to the numerical and functional impairments observed in EPCs with aging.
Increased susceptibility to infection and reduced response to vaccination are due to immunosenscence in combination with medical history and lifestyle factors.
Increased susceptibility to infections , particularly respiratory viral infections , is a hallmark of advancing age.
Increased symptoms of depression are also associated with greater cognitive impairment and risk of dementia in old age.
Increased synthesis of glutathione , humanin , and mitochondrial chaperone proteins are other additional consequences of increased mitogenesis and which would help ensure proteostasis.
Increased systolic blood pressure is associated with adverse outcomes , including stroke , cardiovascular disease , and death.
Increased TA activation was observed in @percent@ of MVC for older people.
Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers.
Increased tendon compliance enlarged GAS and SOL tendon excursions , shortened fiber operation lengths and affected muscle excitation patterns.
Increased thoracic kyphosis angle and weak back muscle strength were also determined as risk factors for limited shoulder abduction ( p < @number@ ) .
Increased tissue-derived collagenolytic activity with TNF-α exposure was blocked by neutralizing MMP-1 monoclonal antibody and was not due to down-regulation of tissue inhibitor of metalloproteinase-1.
Increased trabecular resorbing surfaces , perforated or disconnected trabeculae and microcallus formations were observed with age.
Increased translation of WNT16 can thus lead to an increased inhibitory action of WNT16 on canonical WNT signaling.
Increased understanding of oxidative stress and protein alterations in easily obtainable peripheral tissues will be helpful in developing biomarkers to combat this devastating disorder.
Increased use of elective single embryo transfer ( eSET ) can reduce this twin rate.
Increased use of gastroprotective medication might be justified in this context.
Increased utilization of external memory strategies was significantly associated with better PM performance.
Increased variability in older adults could not be attributed to differences in head movements between the groups.
Increased vascular calcification and endothelial dysfunction are also characteristic of arterial aging.
Increased vascularization and formation of microcracks in joints during OA have suggested the facilitation of molecules from cartilage to bone and vice versa.
Increased warm temperature and decreased cold temperature may increase the risk of ventricular arrhythmias.
Increased α-syn levels can occur in brains of aging human and neurotoxin-treated mice.
Increase in air pollutants concentrations was significantly associated with F3 , ICAM-1 , and TLR-2 hypomethylation , and IFN-γ and IL-6 hypermethylation.
Increase in all indicators of pro-oxidant system of blood plasma with age was determined.
Increase in fat mass over five years was associated with concurrent FEV1 and FVC decline.
Increase in △HRV was observed in hemodialysis patients without stroke but not in stroke patients.
Increase in human life expectancy has resulted in the rapid growth of the elderly population with minimal or no intellectual deterioration.
Increase in instrumental support did not buffer cognitive decline , instead there were indications for faster decline.
Increase in level of impairment resulted in a decrease in Spatial Span Total Score.
Increase in life expectancy was associated with relatively old age at the time of death for five of seven diseases.
Increase in muscle mass and strength through resistance exercise ( RE ) has been highly recommended for healthy aging.
Increase in opportunistic pathogen invasion in the gut like Clostridium difficile leading to C. difficile infection is more common in the elderly population.
Increase in p16 ( INK4a ) , a robust in vivo marker for fibroblast aging , may contribute to the observed phenotype.
Increase in serum levels were together with just only a slightly increase in intra-erythrocyte measurements and the relationship was very weak.
Increase in sleep duration was greatest in those who were short sleepers , heavy drinkers , or had sleep difficulties.
Increase in stress exposure and shifts in signaling pathways with age change the biology of cardiomyocytes.
Increase in tumor necrosis factor alpha ( TNFα ) was partially blocked by CHIA.
Increase of orbital fat volume contributed to lower eyelid prominence.
Increases are likely associated with increases in care costs for chronic conditions , attributable in part to the aging of the population.
Increases in BC measures were evaluated as a function of increased calorie intake or change in physical activity , using linear regression.
Increases in BDNF levels imply neurogenesis may be a component of the mechanism underpinning the cognitive improvements associated with multimodal exercise.
Increases in BMD and P1NP levels were observed both overall and in most individual patients.
Increases in dyspnea intensity ratings with the addition of DS were similar at standardized submaximal work rates in older and younger groups.
Increases in emotional support also directly enhanced cognitive performance.
Increases in graygray matter along with increases in amygdala and frontal cortex activation were evident after a yoga intervention.
Increases in life expectancy and the aging of a large segment of the population have made age-related disability and morbidity increasingly important issues.
Increases in overall self-esteem and appearance- , social- , and performance-related self-esteem were observed in participants treated with BoNTA.
Increases in plasma insulin and exercise / muscle contraction lead to recruitment of additional MVUs.
Increases in positive marital quality were also linked with declines in functional limitations for middle-aged and older adults.
Increases in QRS or QT intervals were transient , and there was no increased incidence of ventricular arrhythmia observed with vernakalant compared with placebo.
Increases in ROS intermediates were accompanied by an aberrant , nonproductive reorganization of actin filaments.
Increases in self-esteem , by contrast , can ameliorate older adults ' cortisol regulation in stressful circumstances.
Increases in the life expectancy of people with Intellectual Disability have followed similar trends to those found in the general population.
Increases in these @number@ activities in particular compensate for declines in engagement levels over time in most other activities.
Increases in visual noise were also positively correlated with increases in movement error during a reach and hold task.
Increases in weight are maintained throughout treatment and beyond.
Increases of just @number@ cm / s are associated with lower mortality.
Increases or decreases in the contractile response of smooth muscle underlie important pathological conditions such as hypertension , incontinence and altered gastrointestinal transit.
Increases were associated with the number of apolipoprotein E ε4 alleles.
Increasing age and comorbid medical conditions also impact PrU development as important risk factors for PrU development.
Increasing age and lower global cognition were not consistently associated with PA participation.
Increasing age and presence of an APOE ε4 allele were associated with higher composite 18F-florbetapir binding.
Increasing age compounds the poor prognosis of GBM , as elderly patients have markedly worse outcomes than younger patients.
Increasing age correlated positively with coexisting arterial aneurysms ( P = 0.044 ) .
Increasing age correlated with SSS , and the @number@ patients with isolated L5-root compression were significantly younger than patients with multi-root involvement.
Increasing age had no influence on levels of synaptic protection.
Increasing age has an impact on each stage of deglutition.
Increasing age is accompanied by decreasing segregation of brain systems.
Increasing age is a risk factor for many varieties of cancer , including most non-AIDS-defining malignancies.
Increasing age is associated with a reduction in overall heart rate variability as well as changes in complexity of physiologic dynamics.
Increasing age is associated with deficits in a wide range of cognitive domains as well as with structural brain changes.
Increasing age is associated with reduced bone mineral content and increased risk of fractures.
Increasing age is associated with the occurrence of surgical site infections.
Increasing age is certainly the most essential age-related cataract risk factor.
Increasing age is the most significant risk factor for neurodegenerative diseases associated with amyloid plaques.
Increasing age seems to be associated with lower prescription rates.
Increasing age , smoking , gender , and hypertension are the factors positively associated with vulnerable nutritional status.
Increasing age was accompanied by less differentiated network topology and a corresponding reduction in activation selectivity ( or differentiation ) across relevant network nodes.
Increasing age was also significantly associated with a lower PCT in both ED and AD participants.
Increasing age was associated with generally slowed performance.
Increasing age was associated with greater rates of physical and health problems and poorer function , and showed curvilinear relationships with pain and psychosocial difficulties.
Increasing age was associated with poor outcome in admitted elderly SE patients.
Increasing age was clearly accompanied by a stiffening of the investigated cells.
Increasing age was independently associated with PDR in both sub-groups.
Increasing age was independently associated with postoperative mortality ( p = @number@ ) .
Increasing age was not associated with a higher reporting of sick-leave but the duration of the sick-leave increased somewhat with age.
Increasing appreciation of the heterogeneity of Alzheimer disease may lead to novel treatment approaches.
Increasing attention has been directed toward the potential role of vascular abnormalities in MTS.
Increasing availability of device therapies for patients with heart failure make prerisk assessment an important management strategy.
Increasing axial length demonstrated a negative correlation with CT , decreasing @number@ µm for each mm of axial length.
Increasing blood pressure factor scores were associated with numerous regions of reduced thickness.
Increasing chain length , loading , grafting ratio significantly enhanced antibacterial activity but reduced the initial CS.
Increasing cholesterol scores , in contrast , were associated with thicker cortex across the whole brain.
Increasing clinical frailty index scores were correlated with low serum alanine aminotransferase , as well as decreased heart rate , and reduced heart rate variance.
Increasing data link myelin impairments with amyloid-β ( Aβ ) plaques and tau hyperphosphorylation , which are both present in patients with AD.
Increasing data now provide evidence for the close association between the IIS and the PN pathways.
Increasing dependence on the descending control system with aging may play a role in falls in elderly people.
Increasing DHA intake from marine sources may be recommended for reducing dementia risk.
Increasing DHEA utilization and publication of a first prospectively randomized trial now warrants a systematic review.
Increasing discussion about late-life potential may alter the stigma associated with aging.
Increasing effort is expended towards dissecting and deciphering the molecular and genetic mechanisms of neurobiological and pathological functions of these brain-enriched miRNAs.
Increasing elders ' social participation and intergenerational solidarity might foster community development and benefit young people , families , communities and the elders themselves.
Increasing evidence demonstrates that long-term aerobic exercise could prevent age-related diseases and improve life quality of aged people.
Increasing evidence demonstrates that LRP1 regulates synaptic integrity and function at the post synapses , at least partially by regulating glutamate receptors.
Increasing evidence from cross-sectional and longitudinal molecular-genetic studies suggests that effects of common genetic variations on cognitive functioning increase with aging.
Increasing evidence from research on motor and cognitive tasks has shown that aging is associated with an expansion of brain activation and an increased BOLD-signal.
Increasing evidence indicates strong opioids as a valid option for chronic pain management in geriatrics.
Increasing evidence indicates that Alzheimer's disease , one of the most diffused aging pathologies , and diabetes may be related.
Increasing evidence indicates that telomerase plays a significant role in maintenance of skin function and proliferation.
Increasing evidence indicates that testosterone may play a significant role in the development of AD.
Increasing evidence links the disruption of the clock genes expression with multiple diseases and aging.
Increasing evidence points to a role of altered microbiota on inflammation , obesity , and other chronic conditions.
Increasing evidence shows physical activity to be associated with improved colorectal cancer ( CRC ) prognosis.
Increasing evidence suggests a role of the immune system in modulation of cognition , but details on affected memory systems are largely lacking.
Increasing evidence suggests that free radical-mediated oxidation of biological substrates is a key feature of Alzheimer's disease ( AD ) pathogenesis.
Increasing evidence suggests that IR can carry out photostimulation and photobiomodulation effects particularly benefiting neural stimulation , wound healing , and cancer treatment.
Increasing evidence suggests that life events play a significant role in many of these changes.
Increasing evidence suggests that periodontal disease might be associated with several systemic diseases ( diabetes , immunosuppression , obesity , hormonal changes ) .
Increasing evidence suggests that pro-inflammatory cytokines are at play in lowering peripheral thyroid hormone levels during critical illness.
Increasing evidence suggests that satellite cells represent a heterogeneous population of cells with distinct embryological origin and multiple levels of biochemical and functional diversity.
Increasing evidence suggests that subjective cognitive decline ( SCD ) is a potential predictor of future cognitive decline or dementia.
Increasing evidence suggests that the cognitive impairment associated with CKD may be related to cerebral small vessel disease and overall impairment in white matter integrity.
Increasing evidence suggest that Phospholipase C γ plays a key role in cell migration and invasion.
Increasing evidence supports the concept that CVD is initiated through developmental in utero processes beginning before birth.
Increasing evidence supports the notion that , like in bacteriophages , mtDNA inheritance is a coordinated interplay between recombination , repair , and replication.
Increasing evidence underscores the health benefits of Tai Chi ( TC ) , although there is limited evidence of benefits among racial and ethnic minorities.
Increasing expenditures on medical care in Japan have been attributed to the aging of the population.
Increasing frequency and severity of heat waves coupled with a rapidly growing at-risk population dramatically increase the extent of future untoward health outcomes.
Increasing frequency of exercise was associated with decreasing risk of developing olfactory impairment ( P value for trend = @number@ ) .
Increasing GDS score levels were associated with increasing risk of hospitalization ( p for trend = @number@ ) .
Increasing glucose scores were modestly associated with areas of regionally decreased thickness.
Increasing health care costs in the US are due in a large part to the increasing prevalence of chronic diseases in an aging population.
Increasing health costs and an aging population will make this issue even more crucial in the future.
Increasing human health and longevity is of global interest.
Increasing insight on these mechanisms is a critical step in the development of age-specific interventions in ASD.
Increasing klotho levels prevented depletion of NMDA receptor ( NMDAR ) subunits in the hippocampus and enhanced spatial learning and memory in hAPP mice.
Increasing labor migration and simultaneous aging of societies are two important demographic developments many poor countries face.
Increasing life expectancy in industrialized societies has resulted in a huge population of older adults with cardiovascular disease.
Increasing lines of evidence support that testosterone may have neuroprotective effects.
Increasing LMMS magnitude from @number@ to @number@ g had no significant influence on outcomes.
Increasingly complex pathophysiological mechanisms have been discovered in recent years with evidence of new molecules involved in the development of CKD - MBD.
Increasingly , interprofessional teams are responsible for providing integrated health care services.
Increasingly latent variable models are used to generate composites of cognitive reserve based on multiple proxies.
Increasingly , older adults are unmarried , which could mean a larger share is at risk of economic disadvantage.
Increasingly , primary care collaborative memory clinics ( PCCMCs ) are being established to build capacity for person-centred dementia care.
Increasingly , research is showing how brain disease or poor physical health negatively impacts brain age.
Increasingly , these models are demonstrating improved outcomes , including admission avoidance or reduced death and dependence.
Increasingly , TOD is seen as important for interpreting and reproducing neuroimaging results.
Increasing mFI was associated with higher prevalence of postoperative morbidity ( p < @number@ ) and 30-days mortality ( p < @number@ ) .
Increasing MIP benefits , particularly for patients with chronic illnesses , should receive priority attention if universal coverage objectives are to be achieved.
Increasing muscle mass is important when attempting to maximize sports performance and achieve physique augmentation.
Increasing nitrite levels via dietary intake of nitrate appears to have similarly beneficial effects in many of the same physiological and clinical settings.
Increasing number of criteria were negatively ( P < @number@ ) related to short-term mortality.
Increasing number of interventions was associated with shorter length of stay , lower rate of restraint use , and lower variable direct costs.
Increasing numbers of adults with intellectual disabilities ( ID ) are living into old age.
Increasing numbers of older people and decreasing rates of edentulism highlight the importance of dental education that focuses on oral health and ageing.
Increasing our understanding of the mechanism for this association could lead to better diagnosis and treatment approaches for osteoporosis.
Increasing participant age was shown to result in a lengthening of the recovery time constant , of a magnitude comparable to previously published psychophysical data.
Increasing physical activity limits fat-free mass loss in men but not women.
Increasing polar surface groups and a water contact angle shift from 60° to 40° are further indications of altered surface properties.
Increasing proteasome activity also resulted in partial relocation of Mig1 from the nucleus to the mitochondria.
Increasing rapidly available hip strength in patients with neuropathic ankle sensory impairment may decrease risk of falls and related injuries.
Increasing rates of infertility and complications are not matched by the marvels in the laboratory.
Increasing rates of organ dysfunction in hospitalized individuals drove the increase in severe sepsis incidence , with an additional small contribution from population aging.
Increasing SBP was associated with higher HF risk in women than in men ; no race-SBP interaction was seen.
Increasing social , economic , and political pressures to reform the U.S. approach to medical care makes change likely.
Increasing storage time or gender difference did not affect the antioxidant activities.
Increasing the frequency of blood donation may thus significantly contribute to both individual and social wellbeing.
Increasing the incidence and prevalence of MS during the recent decades in the low prevalence area such as Iran is explained better by environment factors.
Increasing the salience of the social context , and presumably activating socioemotional goals , did not alter this pattern of performance.
Increasing vascular diameter and attenuated vascular elasticity may be reliable markers for atherosclerotic risk assessment.
Incremental changes of three mandibular measurements from articulare and three from condylion were compared to statural growth changes separately.
Incremental cost-effectiveness ratios ( ICERs ) were calculated.
Incremental cost-effectiveness ratios per quitter and cost-utility ratios per QALY were calculated and presented in acceptability curves.
Incremental cost-utility ratios ( ICURs ) were calculated as cost per quality-adjusted life-year ( QALY ) gained per age category.
Incremental doses of PGI ( @number@ ) and sodium nitroprusside ( SNP ) were administered to the brachial artery during separate trials.
Incremental short-term cost-effectiveness ratios varied greatly when treatments were compared for patient subgroups.
In cross-sectional analyses , we found striking health disparities in olfactory function among older U.S. adults.
In cross-sectional analysis , homebound status was related to depressed affect even after controlling for demographics , health , and function.
In CR , peroxisome proliferator-activated receptors ( PPARs ) seem to contribute to age-retardation partly by regulating mitochondrial function.
In CSF , out of @number@ selected miRNAs only miR-16 and miR-146a could be reliably detected.
Incubation ( 2-7 h ) of rat hippocampal slices with kynurenine ( @number@ μM ) resulted in continuous de novo synthesis of KYNA.
Incubation of endothelial cells with low doses of carbonylated albumin caused a significant increase in intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 mRNA levels.
Incubation of erythrocytes with PTX resulted in increased protein carbonyl content and malondialdehyde and hemolysis percentage compared with control.
Incubation of muscle cells with resveratrol reverted the insulin-resistant state induced by prolonged TNFα or insulin treatment.
Incubation of slices from postweaned rats with kynurenine inhibited α7 nAChRs and extrasynaptic N-methyl-D-aspartate receptors ( NMDARs ) on CA1 stratum radiatum interneurons.
Incubation with ( S ) -nicotine increased d-Ser levels , which were attenuated by the α7-nAChR antagonist methyllycaconitine ( MLA ) .
In Cuba , various factors have led to nearly zero population growth and a rapidly aging society.
In cultured chondrocytes , IL-1β and TNF-α suppressed FOXO1 , while TGF-β and PDGF increased FOXO1 and FOXO3 expression.
In cultured ECs , miR-34a expression was significantly increased by HIV-Tat protein and by the antiretroviral agents , lopinavir / ritonavir.
In cultured ECs , Vash1 mRNA was induced by VEGF , and Svbp mRNA was expressed constitutively.
In cultured HuVSMC the levels of endogenous SirT1 were examined by Western blot analysis.
In cultured keratinocytes , HIF-1alpha was found to be down-regulated shortly after UVB exposure and to be involved in UVB-induced proliferation.
In culture-positive cases , in vitro susceptibility testing should always be performed if antifungal therapy is intended.
In cultures of both groups there was a maximal bacterial growth.
In cultures of SSCs and their progeny , inhibition of SHP2 activity reduced growth factor-mediated intracellular signaling that regulates SSC proliferation and cell fate.
In culture , the patient's skin fibroblasts entered prematurely into senescence , and some nuclei showed a lamina honeycomb pattern.
In current literature , only case reports and small case series touch this topic.
In CV trials , subjects fixated on the handhold throughout the trial.
In daily settings , patients using SAP can achieve a better control than patients using conventional insulin pump.
In @date@ cases , there were multiple infarcts noted on CMR.
In @date@ , CMS released the first of what stakeholders anticipate will be a number of ( annual ) rules related to implementation of MACRA.
In @date@ - @date@ , data were collected through an interview , clinical examinations , and laboratory tests.
In @date@ , male suicide rates in Australia and US were represented by upward-sloping graphs , whereas in Japan the pattern was bimodal.
In @date@ the FDA approved for the first time ever an injectable dermal filler for the augmentation of age-related volume loss.
In @date@ , we searched multiple databases to identify relevant studies including both cohort studies and randomized controlled trials ( RCTs ) .
In DCM ventricles , the levels of Kir2.1 and Kir2.3 were upregulated , but those of Kir2.2 channels were downregulated.
In decedents , regression models were used to examine if UI proximate to death was related to postmortem indices of neuropathologies.
In decision tree analyses , we found that APOE best differentiated cases from controls only in AmnAD but not AtAD.
Indeed , aberrant activation of JNK has been implicated in the pathogenesis of Alzheimer's disease.
Indeed , a form of reverse antagonistic pleiotropy or adaptive senectitude might be occurring.
Indeed , age is the single best predictor of reproductive outcome in women , and the oocyte is the locus of reproductive aging in women.
Indeed , a large number of drugs with differing targets and mechanisms of action were investigated with only a few of them being clinically available.
Indeed , anxiety sensitivity may play an important contributory role in exacerbating impairment through increases in obsessive-compulsive symptom severity.
Indeed , a recently established field within biological ageing research , ' geroscience' , is focused on healthspan extension.
Indeed , a regular exercise exerts a great influence on several parameters and biological pathways , both at genomic and post-genomic levels.
Indeed , as their upper limb strength and dexterity differed , even if their decline was similar , the phenotypes should not be pooled.
Indeed , a strict regulation of blood serum glucose by the use of insulin promotes a better outcome for TBI patients.
Indeed , a surprising protective effect of the ApoE3 genotype was observed in aged females.
Indeed , being a relative of centenarians qualified as an independent correlate of thyroid parameters.
Indeed , both age and gender-associated RBPs in liver were found to show significantly higher clustering coefficients and network centrality measures compared to non-associated RBPs.
Indeed , centenarians display lower plasma cytochrome C levels , higher mitochondrial membrane potential and also less cellular damage accumulation than septuagenarians.
Indeed , clinical studies have supported its use as an alternative to surgery in certain patient populations.
Indeed , clonal hematopoiesis is associated not only with increased risk of hematologic malignancy , but also with cardiovascular disease and overall mortality.
Indeed , comparisons of wild and captive primate populations indicate similar levels of energy expenditure.
Indeed , COPD has been considered a condition of accelerated lung aging.
Indeed , DHA is selectively concentrated in the synaptic and retinal membranes.
Indeed , diseases such as cancer can occur in the offspring due to epigenetically-inherited gene expression profiles induced by stress experienced by the parent.
Indeed disrupted neuronal insulin action may underlie the link between diabetes and neurodegenerative disorders.
Indeed , DNA fragmentation and -oxidation were strongly increased in the stressed Atg7 deficient cells upon PQ stress but also after oxidizing ultraviolet A irradiation.
Indeed , during the last decades , obesity and osteoporosis have become a major health threat around the world.
Indeed , experiments using Drosophila have shown that AMPK may exert protective effects with regard to life span and neurodegeneration.
Indeed , factors in the circulation have been shown to modulate ageing and to rejuvenate numerous organs , including the brain.
Indeed , FGD5 correlates with apoptosis in endothelial cells during vascular remodeling and was linked to rising p21 ( CIP1 ) levels in aging mice.
Indeed , generative concern has been found to be associated with meaning in life.
Indeed , germinal FOX gene mutations cause diseases ranging from infertility to language and / or speech disorders and immunological defects.
Indeed , HCH6-1 bound to FPR1 in human neutrophils and neutrophil-like THP-1 as well as hFPR1-transfected HEK293 cells.
Indeed , higher brain signal variability has been associated with better cognitive performance in young adults compared to children and elderly adults.
Indeed , hyperpolarized mitochondria are known to induce oxidative stress.
Indeed , hypoxia , hypertension , hypoperfusion , endothelial dysfunction , inflammation , and oxidative stress noted in OSA patients also occur in AD patients.
Indeed , ICAM-1 mediates generation of acto-myosin contractility downstream of the Src kinases in stromal fibroblasts.
Indeed , impaired brain plasticity may be one of the pathophysiological mechanisms that underlies both cognitive decline and major depression.
Indeed , in certain situations , reduced autophagosome induction may actually provide benefits to ageing cells.
Indeed , increased gene dosage of Arf / p53 displays elongated longevity and delayed aging.
Indeed indoor air quality might be distinctively contrasted with what is normal for a quality living environment.
Indeed , infections in the elderly are often associated with higher morbidity and mortality , and may present atypically.
Indeed , inhibition of ribosomal DNA transcription leads to mitochondrial dysfunction in a number of cell lines.
Indeed , in the presence of MAF14001 , Aβ was less susceptible to fibrillation.
Indeed , isoform specificity and toxicity represents a big hurdle in the development of Phospholipase C γ small molecule inhibitors.
Indeed , it acts independently of growth factors and leads to enhanced cap-dependent mRNA translation initiation and increased protein synthesis.
Indeed , it appears that some accelerated aging disorders that show neurodegeneration also have mitochondrial dysfunction.
Indeed , it has been suggested that there is no human ' ageing process' , only distinct , disease-specific mechanisms of pathology.
Indeed , it is apparent that cadherins participate in a range of morphogenetic events that range from support of tissue integrity to dynamic cellular rearrangements.
Indeed it is generally accepted that short wavelength light effects is one cause for loss of photoreceptor function in age-related macular degeneration.
Indeed , it is one of the most popular supplements in the US.
Indeed , it is valuable as a means of increasing understanding of ovarian pathophysiology and for guiding clinical management across a broad range of conditions.
Indeed , it is well documented that in vitro expansion reduces replicative potential and some multi-potency and promotes cell senescence.
Indeed , leukocyte telomere shortening predicts early mortality and medical illnesses in non-depressed populations.
Indeed , loss of autophagy gene function significantly influences longevity.
Indeed , manipulation of arousal , such as by muscle tension , can influence memory even when it occurs shortly after learning.
Indeed , many aspects involved in the control of lifespan appear to be well conserved among species.
Indeed , many DNA-damaging agents act through enhancing topoisomerase DNA cleavage.
Indeed , many opportunities exist to apply multilevel selection models employed in evolutionary biology and biodemography to improving human health at all hierarchical levels.
Indeed , many single-nucleotide polymorphisms ( SNPs ) associated with longevity were identified in genes encoding proteins that take part in this metabolic pathway.
Indeed , membrane proteins are significantly less palmitoylated in CLL cells compared with normal B cells.
Indeed , MF-mediated NANOG delivery increased proliferation and enhanced the differentiation of hHF-MSCs into smooth muscle cells ( SMCs ) .
Indeed , multiple studies have described how molecular information about parent tumors can be extracted from these components.
Indeed , mutations of the enzymes and cofactors responsible for these processes are often associated with neurodevelopmental and psychiatric disorders.
Indeed , no change in the expression of the typical senescence-associated premalignant cell markers in the DOX-induced senescent K562 cells was found.
Indeed , normative data for the SDMT that are representative of a national population have not previously been published.
Indeed , observational studies have shown that high uric acid is associated with high level of pro-inflammatory cytokines in the blood.
Indeed , older adults with impaired cognitive control networks tend to demonstrate poor response to a majority of existing depression interventions.
Indeed , older children showed better upper limb movements.
Indeed , OSA and hypertension trigger hypoperfusion and hypometabolism of brain regions , including cortex and hippocampus.
Indeed , PDGFB expression induces , in the same cell population , both senescence and cellular transformation.
Indeed , PlGF-deficient RA-FLSs showed a decrease in cell proliferation , migration , and invasion , but an increase in apoptotic death in vitro.
Indeed , recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of Aβ accumulation.
Indeed , recent studies have shown discrepancies in cytokine mRNA and protein expression between the peripheral blood and bronchoalveolar lavage immune cells.
Indeed , severe morbidities ( e.g. : cardiovascular disease , hypertension ) are still too often associated with diabetes.
Indeed , Shh signaling in Mdm2-deficient GNPs is attenuated , concomitant with decreased expression of the Shh transducers , Gli1 and Gli2.
Indeed , some older individuals seem to use compensatory mechanisms to maintain a high level of performance when submitted to lexical tasks.
Indeed , some studies have identified senescent cells as potential therapeutic targets in the treatment of aging and age-related diseases.
Indeed , successful implementation of these paradigm shifts in ophthalmology may provide useful guidance for similar developments in all of healthcare.
Indeed , such measures have already been used successfully in a number of trials aimed at preventing disability in older adults.
Indeed , the adaptation of the conventional technique of the female facelift would lead to an unnatural result , not satisfactory for the patient.
Indeed , the Clopidogrel and the Optimization of GI Events Trial , which would have had such characteristics , was stopped prematurely.
Indeed , the fastest growth is found in those over the age of @number@ years or octogenarians.
Indeed , the identification of the roles of the Lamin A / C in cardiomyocytes function is a key area of exploration.
Indeed , the optimization of standard of care of elderly glioblastoma patients in an aging population in Western countries becomes crucial.
Indeed the principles of managing type @number@ diabetes are similar to younger patients.
Indeed , there has been little research into the content of any balance training classes.
Indeed , there is an urgent need to understand the mechanisms linking unhealthy diet and mental disorders.
Indeed there is much debate about how to enhance the caring cultures within which health care is provided.
Indeed , these agents even appear to orchestrate sophisticated cognitive functions , including learning and memory.
Indeed , these two new drugs afford appreciable assistance in daily care practice , helping to prevent bone loss in patients with osteoporosis.
Indeed , the slowing down of metabolism with age may result in lower uraemic toxin concentrations , hence reducing their toxic effects.
Indeed , the social benefits of being considered attractive to their peers became an attitudinal barrier to the teenagers ' adoption of skin-protective behaviours.
Indeed , the usual single-specialist model of care is gradually being abandoned worldwide.
Indeed , those defects are considered major contributors to the aging process.
Indeed , topical agents are the first-line treatment for limited disease.
Indeed , TOR signaling regulates cell energy homeostasis by coordinating anabolic and catabolic processes for survival.
Indeed , two third of cancers newly diagnosed occur over @number@ years.
Indeed , various descriptive studies have indicated that histone modifications occur at promoters of clock-controlled genes ( CCGs ) in a circadian manner.
Indeed , we demonstrate that DAF-25 is required for proper DAF-11 ciliary localization.
Indeed , we found that ectopic expression of RBM24 decreased , whereas knockdown of RBM24 increased , the levels of p63 transcript and protein.
Indeed , we found that extensive post-reproductive lifespan allows resource reallocation to increase fertility of the children and survival of the grandchildren.
Indeed , with advancing age there is a modification of immune cell circadian function especially in lymphocytes.
Indeed , with the increasing aging of the population , and poor therapeutic observance , there is an increased risk of hemorragic adverse effects.
In delivering CBT-I to older adults , modifications are sometimes necessary to accommodate for medical problems , lifestyle , social factors , and patient preferences.
In demented PD patients , lower sleep spindle amplitude in parietal and occipital areas was associated with poorer visuospatial abilities.
In dementia patients having more diseases also related to a significantly faster decline in daily functioning.
In demonstrating this , our findings suggest a novel regulatory role for Nav1.5 in cellular biological processes in addition to its electrophysiologic function.
In dentin bonding , contemporary dental adhesive systems rely on formation of the hybrid layer , a biocomposite containing dentin collagen and polymerized resin adhesive.
In dentin , the demineralization affected the superficial and sub-surface areas.
Independence in ADL was improved by @number@ standard units ( @percent@ CI : @number@ @date@ ; P = @number@ ) .
Independence in meeting these needs is important to maintain a good quality of life ( QoL ) .
Independence in physical functioning was related to unchanged LS , stratified for age and gender during a 3-year follow-up.
Independent and paired t-tests , chi-squared tests and covariance analysis were used to analysing data.
Independent associations of key factors including shifts , stress , and age with IL-8 levels were further assessed in a multivariable generalized estimating equations model.
Independent baseline variables with a p-value of < 0.15 in the univariate analyses were included in the multivariate analyses.
Independent blinded assessment and investigator assessment were performed , using the Fitzpatrick Wrinkle and Elastosis Scale ( 0-9 ) and the Global Aesthetic Improvement scale.
Independent component analysis of fMRI data identified task-related brain networks.
Independent control of RF polarity through each one of the @number@ electrodes allows significant reduction of energy flow through the epidermis with increased dermal penetration.
Independent effects of sex , HIV status , and aging on immune activation may contribute to cardiovascular disease in this population.
Independent factors associated with new development of CKD were analyzed by using the Kaplan-Meyer method and the Cox proportional hazards model.
Independent factors predicting toe flexor and handgrip strength were also determined.
Independently associated psychological variables were : poor self-perceived health , cognitive impairment and depression.
Independently of their age , individuals produce weak logical responses when they solve the Wason selection task.
Independently of these characteristics , frailty prevalence varies substantially across geographic regions.
Independently , the two intervention types have been found to improve functional performance in people with dementia.
Independently , three researchers watched all movies , scored symptoms , capacities , and behaviors.
Independent of age and muscle strength , old and young adults similarly prioritized stability of the ground reaction force vector during sit-to-stand.
Independent of age , belief ratings identified two factors : \ "deep \ " and \ "shallow \ " encoding strategies.
Independent of age or natural vision , visual acuity can be significantly improved by using magnification devices.
Independent of chronological age , high circulating levels of proinflammatory markers are associated with a high risk of multiple adverse health outcomes in older persons.
Independent of cognitive decline , initial psychosis was associated with worse subsequent increases in dependence.
Independent of covariates , δ is associated significantly with @number@ serum biomarkers.
Independent of deep white matter-FA , right frontal and right occipital SWM-FA-mediated age effects on motor-speed and visuomotor-attention / processing speed , respectively.
Independent of nutritional status , after @number@ months @percent@ of participants had not regained their prefracture level of independence in ADL.
Independent of subfield volumes , advanced age was associated with poorer performance across all trials , even after reaching the asymptote.
Independent post-market authorization clinical studies need to be completed in order to ensure a need-oriented and efficient treatment with new oncologic substances.
Independent predictors of antibody responses were determined using multivariate Tobit regression models.
Independent predictors of in-hospital mortality in IE were hemodialysis and congestive heart failure.
Independent predictors of perceived age were identified by multivariate modelling.
Independent predictors of poor CS in the HIV-infected group were positive frailty status and current HIV viral load > 2 log copies / ml.
Independent prognostic factors of group C in the multivariate analysis were pancreatic cancer and reoperation.
Independent raters assessed comprehensiveness of reporting of included studies.
Independent replications with larger , more diverse samples , longer treatment durations and more rigorous study designs are required to validate these preliminary findings.
Independent risk factors for severe malaria included parasitemia and angiopoietin-2 in knowlesi malaria , and HRP2 , angiopoietin-2 , and microvascular dysfunction in falciparum malaria.
Independent risk factors were sought by multivariate analysis.
Independent samples t-tests determined mean differences between the above or below RDA protein groups.
Independent sample t-test and chi-square tests were performed for analyses.
Independent t-test and two-way analysis of variance ( anova ) were performed.
Independent t test , Mann-Whitney and χ tests were used to determine the association between parametric and nonparametric variables and DLSS.
Independent t-tests were applied for post-hoc analyses.
Independent validation of our automated WMSA detection algorithm and school age follow-up are important next steps.
Independent variables included both self-reported and performance-based PF measurements.
Independent variables regarding time since baseline , in addition to various time-dependent and time-independent covariates , were obtained in @number@ @number@ @number@ and @number@
Independent variables were expectations and receipt of filial piety from the older adult's perspective.
In depressed patients , suACC ReHo scores positively correlated with PFC thickness and with FC strength.
In-depth interview data were collected from a theoretical sample of @number@ family caregivers , older home care recipients , and home care providers.
In-depth interviews were conducted among @number@ subjects , including subjects classified as adherent and as non-adherent.
In-depth interviews were conducted to collect data and an adapted grounded theory approach was used for data analysis.
In-depth interviews were conducted with @number@ disabled Victorians , aged between @number@ and @number@ years , and an inductive thematic analysis undertaken.
In-depth interviews were conducted with @number@ women with mild-to-moderate intellectual disability.
In-depth interviews with @number@ women aged @number@ to @number@ years were conducted to examine their personal and collective narratives regarding sexuality in later life.
In-depth interviews with the older adults and written feedback and focus group discussions with the CMs provided the data.
In-depth investigation of neurophysiologic responses to footwear interventions is necessary to help confirm any sensorimotor adaptations.
In-depth qualitative interviews were conducted with @number@ gardeners aged between @number@ and @number@ who had tended their garden over an extended period.
In-depth , semistructured interviews were conducted in two sessions with nine postmenopausal women.
In-depth semi-structured interviews were conducted with @number@ key informants and triangulated with document research and observation.
In-depth semi-structured interviews were conducted with @number@ participants aged @number@ to @number@
In-depth semi-structured interviews were conducted with @number@ participants aged @number@ to @number@
In-depth semistructured interviews were conducted with @number@ participants from five service disciplines.
In dermatology , honey , green tea , and vitamin C have been used as topical treatments for a variety of diseases.
In describing decisions , participants referred to concepts such as expertise , practice ideals and approaches to care.
In detecting FTLD with visual rating , sensitivity / specificity was 81 / 94% compared to AD and 81 / 64% compared to MCI.
In developed countries , bacterial pneumonia has become more common than Pneumocystis pneumonia.
In developed countries , economic and financial well-being is playing a crucial positive role in ageing and inclusion processes.
In developed countries , the prevalence of H. pylori infection has decreased but continues to be considerable.
In developing countries , adult children are primarily responsible for the care of their elderly parents.
In developing countries , ESRD incidence will increase to the extent that economic development allows.
In developing countries , the population dynamics are similar , if not more dramatic.
In developing countries with low institutional support , such as Mexico , social integration can be particularly consequential for widowed older adults ' psychological well-being.
In development , the lens grows through massive elongation of epithelial cells possibly recapitulating the evolutionary origins of the lens.
Indexation of left ventricular mass differentiates the diagnostic ability of ECG criteria , especially in older patients.
Index cases included a clinic-referred sample of @number@ @number@ men who underwent SA and had adequate familial and follow-up data in the UPDB.
Indexed LV mass did not vary with age.
Indexes for arterial stiffness are , by their nature , influenced by the ambient blood pressure due to the curvilinear nature of arterial compliance.
Indexes increased at the last follow-up , showing no statistically difference.
Indexes of mitochondrial density were similar across the groups and intervention.
Indexing sodium intake for caloric intake and body mass index did not materially affect the results.
Indexing vessel flows to TCBF neutralized the age effect , but anatomic variations continued to impact indexed flow in the BA and internal carotid artery.
India , along with the rest of the world , is aging rapidly , but more so.
In diabetic patients , the conditions needed to promote AGE formation are all present , and are further accentuated by accompanying renal failure.
India crossed the United Nations definition of an aging country when the population of persons aged older than @number@ years exceeded @percent@.
In dialysis patients , vascular calcifications are widespread and are connected to bone health.
India , South East Asia , China , and United States lead the world in air pollution.
Indications and methods , as well as the results of plastic surgical treatment , seem varied.
INDICATIONS : Common indications include resurfacing for acne , chickenpox and surgical scars , periorbital and perioral wrinkles , photoageing changes , facial dyschromias.
Indications of mitral surgery , the only current approved treatment of MR , are disputed.
Indications were osteoporotic fractures , metastasis or fractures on ankylosing spine.
Indicators can be followed over time in an individual clinic.
Indicators of adverse consequences of unmet need could be used to monitor the quality and adequacy of such care systems.
Indicators of poor health status such as disability and loneliness were associated with greater RRR of high or moderate frequency of self-perceived uselessness.
Indicators of social isolation were combined into scales assessing social disconnectedness and perceived isolation.
Indicator values are used to obtain population health profiles and to compare different LHUs ' profiles within the same region or between different regions.
Indices for spatial heterogeneity and systolic dyssynchrony were determined for healthy abdominal aortas and abdominal aneurysms.
Indices of acinar ( Sacin ) and conducting ( Scond ) airway ventilation heterogeneity were calculated from the multiple breath nitrogen washout.
Indices of extracellular ( noncontractile ) and cellular ( contractile ) compartments in skeletal muscle tissues were determined using the Cole-Cole plot from S-BIS measures.
Indices of heart rate variability were not associated with hypertension onset.
Indices of pain ( threshold , tolerance , intensity , unpleasantness , facial expressions ) and facial expressions of emotion were analyzed.
Indices of social isolation are risk factors for incident dementia in this population.
In dietary analyses , @number@ DM cases occurred during @number@ person-years.
In different ages , the prevalence were ranged from @number@ to @percent@.
In different ages , the prevalence were ranged from @percent@ to @percent@.
In different modes of speaking and paralinguistic signs almost @percent@ older people spoke normally , about @percent@ kept silent , while they rarely quarrelled.
In different regions , the prevalence were ranged from @percent@ to @percent@.
In different working groups the experts developed solutions and recommendations with regards to political need , health care and future research priorities.
In differing societies its descent and thinning with time have made it an important benchmark of the aging process.
In difficult listening conditions , these factors may induce cognitive overload relatively early or they may be associated with relatively shallow speech processing.
Indigenous Australians have @number@ @number@ fewer nephrons than non-Indigenous Australians.
Indirect ceramic , direct restorative composite , and preformed composite veneers showed comparable failure rates and satisfying longevity.
Indirect composite inlays were fabricated.
Indirect connectivity analyses revealed that tract-specific functional connectivity is affected by lesions in several tracts simultaneously.
Indirect costs included labor supply-based income data , and all social transfer payments obtained from the Coherent Social Statistics.
Indirect costs included the effect on labor supply.
Indirect costs ( reduced and lost work productivity ) outnumbered direct costs three times.
Indirect costs were excluded.
Indirect costs , which included labor supply and social transfer payments , were based on income data derived from the Coherent Social Statistics.
Indirect effects involving sexual identity factors , social resources , and SES explained the association between bisexual identity and poorer health.
Indirect effects of SES through the mediators were evaluated by using a multiple mediator model.
Indirect effects were also found for street disorder with SPPB scores ( β = @number@ p < @number@ ) .
Indirect evidences of decrease in level of lymphocytes activation in women of young and middle age at pneumonia development were received.
Indirect ophthalmoscopy with scleral indentation is needed in order to find possible retinal break ( s ) , on-time treatment and prevention of retinal detachment.
Indirect path from education to cognition , mediated by current SEP , was small.
In direct practice settings , when assessing caregiver stress and burden , the history of childhood maltreatment needs to be taken into account.
In dissected aortas , the true lumen volume was correlated to age ( r = 0.72 ) .
In distinction , E2 reduced LBD binding to HDAC3 , whereas Tmx had no effect.
In distinction , only HDAC3 knock-down led to increased activity in the presence of Tmx.
Individual age at death was related to military height measurement at age @number@
Individual agreement had to be met to continue working life.
Individual alpha frequency peak ( IAF ) determined the delta , theta , alpha @number@ alpha @number@ and alpha @number@ frequency bands.
Individual- and institution-level implications are discussed.
Individual and societal positive views of ageing should be encouraged.
Individual and work-related factors were assessed through questionnaires and work logs.
Individual assessment and treatment are important for older people at high risk of falls and injury.
Individual assessments of uncontrollable threats to health may be an important determinant of smoking and physical activity.
Individual association analyses were conducted in each stratum and meta-analyzed across all @number@ discovery data sets.
Individual BAS were significantly correlated with CA ( r = @number@ p < @number@ ) .
Individual BOLD activation maps for the n-back task were correlated with TCD measures and network-level averages were associated with TCD and preferred walking speed.
Individual care plans can assist all involved.
Individual differences in brain functional networks may be related to complex personal identifiers , including health , age , and ability.
Individual differences in contrast sensitivity better predicted cognitive test performance than did visual acuity.
Individual differences in local and global efficiency during resting-state sessions were not significant predictors of working memory performance.
Individual differences in single-task performance accounted for more than half of the variance in dual-task performance.
Individual differences in subjective effort could present a major and pervasive confound in behavioral and neuroscience assessments , by conflating cognitive ability with cognitive motivation.
Individual differences in views on aging were mainly due to individual-specific environmental and genetic effects.
Individual differences in working memory ( WM ) performance have rarely been related to individual differences in the functional responsivity of the WM brain network.
Individual differences were seen in these developmental trajectories.
Individual evaluations were rated as good , fair , or poor using methods consistent with those recommended by the Agency for Healthcare Research and Quality.
Individual FAS showed high longitudinal stability for age-related changes.
Individual FAS was predicted from these five fitness markers using a principal component model.
Individual food companies must adapt to changing nutrition knowledge , dietary guidelines , and consumer priorities.
Individual foods consumed simultaneously , like coffee with milk , are given codes to identify these combinations.
Individual fractional anisotropy and mean diffusivity maps were generated using FSL-DTIfit.
Individual images were spatially warped to a common anatomical frame of reference.
Individual interviews collected information on SRH , perceived social support , social network , and other covariates.
Individual interviews were conducted with @number@ community-dwelling New Zealand elders : four Maori aged 71-93 years and @number@ non-Maori aged 80-97 years.
Individual interviews were transcribed verbatim using a constant comparative analysis.
Individualised care was seen as an overarching theme linking each of these dimensions.
Individualization of protein intake is warranted.
Individualized activities resulted in a significantly greater beneficial effect than standard care ( SMD : @number@ @percent@ CI : @number@ to @number@ ) .
Individualized assessment and interventions targeted to stage of behavior change for each component of ACP may be an effective strategy to increase participation in ACP.
Individualized care has been promoted by long-term care insurance policies , but further advances will require efforts to obtain the understanding of the insured.
Individualized exercise strategies and regimens make it possible , however , for every elderly adult to benefit from physical activity.
Individualized progress reports were mailed quarterly.
Individually , PIB-PET generated the best sensitivity , and fluorodeoxyglucose PET had the lowest.
Individually such alleles have little predictive values , therefore they were usually excluded from further analyses.
Individual MD and FA images were coregistered to T1-weighted volumes using FLIRT of FSL.
Individual medical histories were reconstructed using information on diagnoses coded in MFSU , dates of medical services / procedures , and Medicare enrollment / disenrollment.
Individual MMP species were separated by gelatin-substrate zymography and the levels were quantified by densitometric techniques.
Individual MMSE items demonstrated poor construct validity.
Individual neurons in addition show reduced size of dendritic and axonal arborization.
Individual NINL scores over this period were highly correlated.
Individual participant data were harmonized and pooled.
Individual participant position errors correlated poorly with respective thresholds , indicating a lack of concurrent validity.
Individual preference of music is preserved throughout the process of dementia.
Individual rates of decline on five cognitive domains were calculated for each patient.
Individual rights and freedom of choice are important components of the assessment process.
Individual RS-ECN maps were estimated using a seed-based cross-correlation method.
Individuals ' 10-yr CVD risk was determined using the Framingham risk model.
Individuals achieving seroprotective levels of influenza antibody ≥160 units had higher optimism , less anxiety , and lower perceived stress than the nonresponders.
Individuals age > 65 years old are the fastest expanding population demographic throughout the developed world.
Individuals aged 70-89 years with complete datasets for the three components were included ( N = @number@ of @number@ @percent@ ) .
Individuals aged and transitioned through different life history stages asynchronously without migration.
Individuals aged between @number@ and @number@ years were included in group I , those aged @number@ years or greater in group II.
Individuals aged @number@ and older have especially high mortality after renal , cardiovascular , and pulmonary complications.
Individuals aged @number@ or older had poorer performances than those aged @number@ to @number@
Individuals aged @number@ to @number@ participated as controls.
Individuals and societies are , respectively , confederations of cells and individuals.
Individuals are embedded in social networks in which they communicate with others in their daily lives.
Individuals assigned to EVO demonstrated @percent@ adherence.
Individuals at risk of functional decline cannot be targeted based on supine CT thoracic curvature measures alone.
Individuals born small for gestational age ( SGA ) are at a higher risk of developing the metabolic syndrome later in life.
Individuals carrying rs11614913 GC or CC genotypes showed @number@.2-fold higher expression compared to GG genotype carriers ( P < 0.05 ) .
Individuals concurrently kept a sleep diary.
Individuals either had seven upper extremity or seven lower extremity muscles measured.
Individuals employed fixed strategies of cooperation or defection towards all neighbours in a basic Prisoner's Dilemma paradigm.
Individuals engaging in exercise using body weight and lifestyle activity ( ≥ @number@ days / week ) were more likely to have knee pain.
Individual sensitivity spectra were derived from measures of melatonin suppression.
Individual sessions highlighted the needs of urban , rural , and suburban communities.
Individuals experiencing pain at @number@ h were more likely not to be recovered ( O.R. = 1.62 , p < 0.001 ) .
Individuals homozygous for inactivating mutations in TREM2 exhibit demyelination of subcortical white matter and a lethal early onset dementia known as Nasu-Hakola disease.
Individuals infected with HIV are living longer due to effective treatment with combination antiretroviral therapy ( cART ) .
Individuals infected with HIV have chronically elevated inflammatory markers despite viral suppression following effective antiretroviral therapy ( ART ) , as well as age-related inflammation.
Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group.
Individuals in the intervention group were also observed to exhibit higher levels of coping.
Individuals in their 30s showed a mixed pattern of under- and over-estimation among observers.
Individuals in the study were administered three capsules per day for @number@ months.
Individuals living with HIV who are optimally treated with combination antiretroviral therapy ( cART ) can now lead an extended life.
Individuals ' moral identity motivation was coded and categorized as external , internal , or relationship-oriented.
Individual SOC components were also negatively correlated with depression.
Individual socio-demographic and health characteristics were explanatory factors for variation in loneliness over time , whereas municipal characteristics were not.
Individuals of all ages reported engaging in AM approximately @percent@ of the time.
Individuals of the same age differ greatly with respect to their health status and life span.
Individuals over the age of @number@ were included in the study , while those hospitalized or in terminal phase were excluded.
Individual-specific slope of the longitudinal trajectory of each biomarker was first estimated.
Individual specimens were classified as control or diseased according to clinical evaluation and neuropathological examination.
Individuals receiving a booster were more likely to be seropositive than those at the same age who did not.
Individuals reported complex medical needs in addition to their HIV and noted difficulty discerning whether symptoms were associated with HIV or aging.
Individuals selected as normal controls for ( @number@ ) H-magnetic resonance spectroscopy consisted of healthy age-matched children.
Individuals spent on average @percent@ of daytime at home , @percent@ at work , and @percent@ at school.
Individuals suffering from Werner syndrome ( WS ) exhibit many clinical signs of accelerated aging.
Individuals treated with TST require monitoring for adverse effects.
Individual , structural , and environmental factors affected the quantity and quality of physical activity accessed by residents.
Individual studies have been small , and limited to a narrow age range.
Individuals under chronic psychological stress can be difficult to identify clinically.
Individual sun exposure history and other factors influencing skin aging were collected by a questionnaire.
Individuals were assessed cross-sectionally using Wechsler Adult Intelligence Scale-Revised ( WAIS-R ) and diffusion-tensor imaging.
Individuals were classified by their BMI using the classification adjusted by age.
Individuals were classified into four groups according to their ages as 20-40 , 41-60 , 61-80 , > 80.
Individuals were cognitively classified as normal ( CN ) , MCI , AD , vascular dementia , or unclassifiable.
Individuals were divided by tertiles of temporal gait variability into categories of high , medium , and low variability.
Individuals were followed from age 70-100 years.
Individuals were instructed to wear the actiwatches for @number@ hr.
Individuals were recruited from @number@ to @number@
Individuals were stratified by age ( ≤80 years , > 80 years ) .
Individuals who are currently receiving antihypertensives are eligible to participate if the participants and the primary care providers are willing to taper their antihypertensives.
Individuals who failed to recover at least @percent@ of their baseline BP by @number@ s post stand were characterized as having impaired orthostatic BP recovery.
Individuals who had a stroke or other diseases that could directly cause dysphagia were excluded.
Individuals who held stronger beliefs ( at baseline ) about the organic nature of pain provided more positive evaluations.
Individuals who lack awareness of their olfactory dysfunction have poor cognitive outcomes and should receive additional clinical scrutiny.
Individuals who underwent LF treatments were more likely to pursue future treatments.
Individuals who were from families with male-to-male transmission or who carried pathogenic hexanucleotide repeat expansions in C9orf72 were excluded.
Individuals who were slow to initiate early selection appeared to be less successful at executing late selection.
Individuals who were underweight or died in the first @number@ years of follow-up were excluded to remove frail elders from the sample.
Individuals with a BMI < 25 had higher scores on the self-absorbed subscale compared to persons with a BMI between @number@ and @number@
Individuals with AD showed a loss of synapses very similar to the aMCI cohort.
Individuals with Alzheimer's disease ( AD ) may be at higher risk of adverse drug events associated with PIMs ( such as falls ) .
Individuals with aMCI had significantly fewer synapses ( @percent@ ) compared to individuals with no cognitive impairment.
Individuals with and without MCR were separated into those with and without MCI.
Individuals with an educational level under the primary school and with the lower family average income were more likely to suffer pedestrian-related injuries.
Individuals with aneuploidy tend to develop malignancies.
Individuals with an ε4 allele had more regional atrophy in the frontal cortex compared to ε4 noncarriers.
Individuals with autism spectrum disorder ( ASD ) and their relatives process faces differently from typically developed ( TD ) individuals.
Individuals with BRD are less likely to consult medical services and be dispensed an antidepressant , compared to NBRD.
Individuals with CKD have a far greater likelihood of cardiovascular death than progression to end-stage renal disease.
Individuals with cognitive impairment received @number@ hours of informal care / month , @number@ times more than people with no / slight impairment.
Individuals with COPD have increased susceptibility to respiratory infections , resulting in exacerbations of the disease.
Individuals with dementia were M = 82.8 ( SD = 6.46 ) years old ; @percent@ were men and @percent@ were women.
Individuals with depression adaptive behavior are most vulnerable to stress and pathological aging.
Individuals with developmental disabilities also expressed feelings of self-efficacy in learning to cook healthy food.
Individuals with disability reported a worse self-perceived health status and a greater number of comorbid conditions.
Individuals with Down syndrome ( DS ) are more likely to experience earlier onset of multiple facets of physiological aging.
Individuals with DS develop Alzheimer's disease ( AD ) neuropathology and have elevated risk for dementia starting in their 30s and 40s.
Individuals with DS often exhibit working memory deficits coupled with degeneration of the locus coeruleus ( LC ) norepinephrine ( NE ) neurons.
Individuals with Dupuytren disease ( DD ) are commonly seen by physicians and surgeons across multiple specialties.
Individuals with ET and cognitive impairment overestimated their performance in all domains of functioning.
Individuals with greater engagement in literacy activities were less likely to have dementia compared to CIND.
Individuals with HFpEF have severe symptoms of effort intolerance , poor quality of life , frequent hospitalizations , and greater likelihood of death.
Individuals with high ametropia mostly had WTR astigmatism although the percentage of ATR astigmatism was high in those with low ametropia.
Individuals with higher apathy levels demonstrated a stronger association between age and processing speed performance.
Individuals with higher education seem to benefit more by engaging in literacy activities , as evidenced by decreased odds of having dementia.
Individuals with high levels of isolation and loneliness initially showed a smaller decrease in evaluative well-being.
Individuals with hippocampal sclerosis of ageing pathology did not show increased rates of clinically documented hypertension , diabetes , or other cardiac risk factors.
Individuals with HIV infection are living substantially longer on antiretroviral therapy , but hospitalization rates continue to be relatively high.
Individuals with hypertension and high lipid levels showed higher PON1 activity.
Individuals with improving trajectory were younger and in poorer mental health at baseline compared to the upper middle-stable trajectory group.
Individuals with intellectual disability ( ID ) are now living longer with the majority of individuals reaching middle and even \ "old age. \ "
Individuals with late-life depression exhibit impairments in cognition and brain structural integrity , alongside mood dysfunction.
Individuals with LBD had a higher risk of respiratory death than those with AD.
Individuals with LLDs have the same goals of health and wellness as those without disabilities.
Individuals with lower baseline ability to abstract gist showed the greatest gain in the target domain trained.
Individuals with lower SRHs-age compared to SRH-global tended to be more vulnerable to depressive symptoms.
Individuals with lower VO2max demonstrated accelerated trajectories of cognitive decline over time.
Individuals with low PAL had higher prevalence of MS as compared to their counterparts.
Individuals with MCI , like Alzheimer patients , had a diminished primacy effect in recalling words from a list.
Individuals with MCI scored worse than cognitively normal participants on the HCD factor but similarly on the LCD factor.
Individuals with md-aMCI are found to exhibit higher risk of conversion to AD.
Individuals with more chronic health problems reported more negative affective experiences when they were with their spouses than not.
Individuals with multiple adverse alleles had @percent@ higher mortality rate than those with none.
Individuals with NER-defective xeroderma pigmentosum ( XP ) , in which bulky DNA lesions are not efficiently removed , are cancer-prone and suffer neurodegeneration.
Individuals with neurological disorders such as dementia are susceptible patient groups in which pain is frequently under-recognised , underestimated , and undertreated.
Individuals with normal-hearing and cochlear implant recipients were asked to make judgments about the synchrony of AV speech.
Individuals without MetS had higher exercise self-efficacy at baseline and performed greater exercise volume compared with individuals with MetS during the intervention.
Individuals with Parkinson's disease ( PD ) often experience cognitive declines.
Individuals with PD exhibited offline losses , marked by an increase in sequence duration between sessions.
Individuals with poor renal function should be assessed for cognitive impairment.
Individuals with predominant negative symptoms and higher BE concentrations are most able to identify negative odors.
Individuals with previous atrial fibrillation , ischemic heart disease , stroke , and peripheral artery disease were excluded.
Individuals with primary progressive aphasia ( PPA ) suffer a gradual decline in communication ability as a result of neurodegenerative disease.
Individuals with SCI showed reduced functional connectivity in cortical midline structures.
Individuals with single and especially multiple chronic morbidity had impaired role functioning.
Individuals with StD , regardless of age , may share common neural characteristics.
Individuals with stronger SOC were less prone to catastrophizing and more often declared that they were coping with and could control and reduce pain.
Individuals with subjective memory complaints show differential brain activation during memory encoding ; however , whether such differences contribute to successful memory formation remains unclear.
Individuals with synaesthesia experience cross-modal mappings to a conscious degree ( e.g. , they may see colours when they hear sounds ) .
Individuals with the highest concentrations of both types of FAs had lower risk of diabetes.
Individuals with the long allelic variant of TOMM40 , which is linked to APOE E4 , showed similar results.
Individuals with uniparental disomy revealed higher spine BMD compared with deletion subclass ; however , the differences were not significant.
Individuals with worse functional status had significantly higher levels of NK cells and fewer B cells.
Individuals ' WTP was elicited based on a contingent valuation method with a payment card.
Individual test scores were combined using factor analysis into executive function and episodic memory scores.
Individual tracts showed no associations beyond what the common integrity factor explained.
Individual trajectories were estimated using mixed-effects models , and differences in trajectories by socioeconomic position ( measured by maternal education ) were investigated.
Individual unique environment is likely to play a major role in determining the levels of cognitive performance.
Individual variation in AM conjunction error vulnerability was attributable to inhibitory capacity.
Individual variations were present in initial WMH volume but not in WMH volume progression.
Individual windows were quantified by Gaussian curve fitting.
In DM , the frequency of previous fracture was higher than in control subjects ( @percent@ versus @time@ % , p < @number@ ) .
In doing so , continuities and divergences that exist between existing literature on midlife transitions and women's own perspectives are highlighted.
In doing so , effective therapeutic strategies can be applied.
In doing so , it inspires researchers to reach out to new populations.
In doing so , particular emphasis should be placed on assessing consciousness.
In doing so the etiology of chronic disease progression will be further understood.
In doing so , the method described herein is a useful tool for accurately quantifying WAT development , growth , and remodeling.
In doing so we hoped to shed new light upon the virtually uncharted area of older men's primary and secondary control beliefs over time.
Indoor environments are characterized by several pollutant sources.
Indoor tripping hazards were associated with falls among stroke survivors and matched controls.
Indoor tripping hazards were associated with falls ( PR : @number@ @percent@ CI : @number@ @date@ ) .
In double-labeling preparations , BACE1 IR colocalized with immunolabeling for Aβ but not for phosphorylated tau.
In double staining experiments , all GVD markers colocalized with pTDP43 in RVs.
In double staining using an anti-neurofilament antibody and Gallyas-Braak staining , Gallyas-Braak-positive structures were located in the neurite.
Indoxyl sulfate may be involved in reduced renal expression of Klotho in CKD.
In Drosophila , a process termed cell competition eliminates slow proliferating cells from growing epithelia.
In Drosophila , Huntingtin genetically interacts with autophagy pathway components.
In Drosophila melanogaster , mitochondrial Hsp22 ( DmHsp22 ) , is localized in the mitochondrial matrix and is preferentially up-regulated during aging.
Induced deletion of SHP-2 resulted in impaired hematopoiesis , weight loss and lethality.
Induced erythroblasts expressed erythroid surface markers and formed erythroid colonies.
Induced pluripotent stem cells ( iPSC ) and their differentiated derivatives offer a unique source of human primary cells for toxicity screens.
Induced pluripotent stem cells ( iPSCs ) were derived from three FRDA individuals with characterized GAA repeats.
Induced sputum was collected @number@ h after exposure.
Inducible deletion of the ciliary protein IFT88 in aNSCs validates the role of ciliary function in aNSCs.
Inducible microRNAs ( miRNAs ) perform critical regulatory roles in central nervous system ( CNS ) development , aging , health , and disease.
Induction of BIM is driven by the transcriptional co-activator CBP ( CREB Binding Protein ) together with the proto-oncogene c-Myc.
Induction of Eng deletion in adult mice using R26CreER plus local VEGF stimulation induced the brain AVM phenotype.
Induction of expression and secretion of NGFβ and elongation of C-fibers into the epidermis were found in the Hypo group.
Induction of HSPs has been shown to decrease oxidative stress , inhibit inflammatory pathways , and enhance metabolic characteristics in skeletal muscle.
Induction of premature senescence in HDFs was accompanied by upregulation of p16INK4a , an important downstream target of BMI1 and a major regulator of senescence.
Induction of senescence either by oncogene activation or inactivation of tumor suppressors is considered a critical feature of mammalian cells by which to suppress tumorigenesis.
Induction of tolerance , defined as permanent acceptance of the transplant in the absence of continuous immunosuppression , is an achievable goal.
Induction VAD chemotherapy was comparable between the elderly ( @percent@ ) and younger ( @percent@ ) group.
Inductive content analysis was performed to analyse the transcripts.
Inductively coupled plasma mass spectrometry was used to measure inorganic arsenic concentration in drinking water.
Industrialized nations face the common challenge of caring for aging populations , with rising rates of chronic disease and disability.
Industry profit data from Euromonitor was obtained to identify the top cosmeceutical brands by retail value in South Korea.
In dyadic interaction , infants engaged with a stranger in face-to-face play interrupted by a still-face episode.
In dyadic interviews , two participants interact in response to open-ended research questions.
In each age group of CAP and NHAP , mortality increased with pneumonia severity.
In each brain area , CRF receptor binding was sexually dimorphic , but no two areas were alike in the way the sexes differed.
In each case , a percutaneous osteosynthesis using cemented screws was performed.
In each case , filler selection was based upon patient characteristics , anatomical considerations and inherent filler properties.
In each case , the results of sensitivity analyses demonstrated stability.
In each cluster , @number@ people over @number@ years of age were chosen systematically and were invited to participate in the study.
In each condition , the subjects wore a small , light-weight sensor ( i.e. , a @number@ dimensional accelerometer ) on their lower back.
In each group , AP and AIX increased even more significantly in females ( P < @number@ ) .
In each group , the similarity of past and future thinking was predicted by flexibility.
In each of these conditions , the predominant mechanism contributing to the loss of skeletal muscle mass is increased protein turnover.
In each participant , average MEP amplitude ( size ) ratios were quantified.
In each round , we calculated statistics describing each standard's validity and feasibility.
In each sample , subjective age , sleep difficulties , depressive symptoms , anxiety and chronic conditions were assessed at baseline.
In each screening stage , the selection criteria were applied to eliminate records where at least one of the exclusion criteria was verified.
In each session , participants selected stimuli , taken from standardized sets , based on their emotional valence.
In each session , subjects performed a visual-spatial interference task based on a Stroop / Simon-like paradigm.
In each study , adjusted mortality ratios ( hazard ratios , HRs ) in relation to SRH were calculated and subsequently combined with random-effect meta-analyses.
In each subject , body mass index ( BMI ) , glucose , total , and HDL cholesterol were also evaluated.
In each subject , the proximal segment of a coronary artery was imaged for the cross-sectional area measurements using cine spiral MRI.
In each task and each phase , variations in MEP characteristics were analysed for age and muscle-dependent effects.
In earlier centuries , the shaven forehead and almost absent brow were seen as a symbol of sexual purity.
In earlier studies , it was found that autophagy in the aging model Podospora anserina acts as a longevity assurance mechanism.
In earlier studies it was shown that the Ne can be explained by a single independent component.
In early onset patients , we found bilateral posterior demyelination spreading to the temporal areas in the left hemisphere.
In early or \ "incipiens \ " ovarian failure , the decrease in serum AMH is far ahead of the increase in FSH.
In EEGs recorded from @number@ patients , SWI was not significantly different between infancy / childhood and adolescence / adulthood.
Ineffective esophageal motility was more prevalent in Groups A and C than in Group B , although the difference was not statistically significant.
Ineffective reminders showed no change across learning trials for octogenarians , while centenarians improved only between Trials @number@ and @number@
In effect , OCC concentrations have dispersed from dense urban cores to suburban neighbourhoods in recent decades.
In EG the BBS-70 % showed @number@ % of cases compared to @number@ % of the CG.
In EG the BI-70 % showed @number@ % of cases , while the BI-70 % of CG showed @number@ % of cases.
In eight of ten cases the methylation change was reverted between obese and lean individuals.
In elderly CKD patients the high prevalence of comorbidities and the often aberrant metabolism of medications have to be considered in individually tailored treatment strategies.
In elderly controls , this went hand-in-hand with a stronger activation of striatal areas.
In elderly inpatients with bipolar disorder , the mean prevalence of late-onset mania was @percent@.
In elderly men , metabolic syndrome had a significant negative association with the total OABSS.
In elderly patients , all SSAs were located in the proximal colon ( particularly the cecum to ascending colon ) .
In elderly patients , bacterial infection often causes severe complications and sepsis.
In elderly patients cognitive dysfunction and other adverse events ( AEs ) can impair the outcome of surgical procedures.
In elderly patients ( > @number@ years ) , the C3-C4 level became the predominant level affected by myelopathy.
In elderly patients the aorta potentially elongates and the vertebral body height decreases.
In elderly patients the atherosclerotic plaques tend to be larger with increased vascular stenosis.
In elderly people , the prevalence of insomnia and depressive symptoms is increased.
In elderly populations , frailty is associated with higher mortality risk.
In elderly risk for development of skin cancer is increased.
In elderly , urinary incontinence is only associated with a higher mortality in men , and elderly men seek more often professional help.
In elderly women , only TGF-βRΙ expression correlated negatively with miRNA-21 expression in PBMCs ( ρ = -0.315 ; p = 0.004 ) .
In enamel and dentin , both , G3 showed significantly more gap formation than G1 and G2.
In enamel , seT showed significantly higher marginal integrity than iCEM after water storage and TCML ( post hoc ; p = @number@ ) .
In endothelial cells , downregulation of SIRT1 evokes cellular senescence.
In endothelial cell-specific SREBP2 transgenic mice , locked nucleic acid-modified antisense miR-92a attenuates inflammasome , improves vasodilation , and ameliorates angiotensin II-induced and aging-related atherogenesis.
In EOAD and LOAD , hypometabolism involved the bilateral temporoparietal junction and the posterior cingulate cortex.
In EOAD , atrophy was widespread , including frontotemporoparietal areas , whereas it was limited to temporal regions in LOAD.
In EPCs isolated from both human peripheral blood and mouse bone marrow , treatment with adiponectin prevented high glucose-induced premature senescence.
Inequalities generally persisted after adjustment for adult SEP.
Inequalities in all-cause mortality were largely explained by the differences in functioning.
Inequalities persisted after adjustment for stage.
Inequities were apparent in the proportion of unmet restorative and prosthetics needs.
In ERCC1-XPF-deficient cells , neither T- nor G-SCE frequencies differed from controls.
Inertial sensor-equipped shoes measured heel strike and toe off angles , and foot clearance.
In essence , the Reproductive-Cell Cycle Theory can explain aging in all sexually reproductive life forms.
In Europeans and Asians , erythrocytic variants in aggregate had only modest effects on the diagnostic accuracy of HbA1c.
In euthyroid participants , we additionally examined the association between fT4 levels and incident AF.
In everyday prospective remembering , individuals must often delay the execution of a retrieved intention until they are in the appropriate setting.
In every other test persons experienced cardiovascular disease.
In examining sex differences , male participants reported higher pain tolerance and female participants displayed more prominent facial expressions of pain.
In experienced hands , PNL can be safely and reliably performed in the treatment of renal stones in elderly patients.
In Experiment 1a , 2- and 3-year olds showed gaze-cued orienting of attention in response to unmanipulated and blurred faces , but not line-drawn faces.
In experimental models , it has been shown that EVOO with high concentrations of polyphenols has anti-inflammatory and anti-oxidant properties.
In experimental models of MI , erythropoietin reduces infarct size and improves left ventricular ( LV ) function.
In Experiment @number@ 3- to 5-year-olds consistently failed to innovate a simple hook tool.
In Experiment @number@ after assessing which informant was ( not ) very good at answering , even 4-year-olds selected the previously correct informant.
In Experiment @number@ age-group differences in associative memory were left to vary and retrieval efficiency was assessed through accuracy.
In Experiment @number@ attentional control skills were measured by instructing participants to deliberately vary attentional priority between the two tasks.
In Experiment @number@ children's performance did not improve given the opportunity to manipulate the objects in a warm-up phase.
In Experiment @number@ coherent motion and relative motion displacement thresholds were obtained.
In Experiment @number@ coherent motion thresholds were obtained for stimuli containing either @number@ or @number@ dots.
In experiment @number@ crash occurrence increased with visual distraction and was negatively related to attention capacity.
In Experiment @number@ goals were set using the same schedule as in Experiment @number@ but no monetary consequences were provided for meeting them.
In Experiment @number@ in the absence of external demands to evaluate the informants , 7-year-olds and adults still selected the previously correct informant.
In Experiment @number@ lower amount of visual feedback minimized the age-associated differences in movement variability for both the index finger and ankle movements.
In Experiment @number@ @number@ cognitively-healthy older adults ( M = 73.03 ) iW , iT , and iWWT during functional magnetic resonance imaging.
In Experiment @number@ older adults completed a lexical-decision task where prime and target words were related either integratively or semantically.
In Experiment @number@ older and younger adults learned maps depicting semantically categorizable landmarks.
In Experiment @number@ older participants were unable to vary their performance according to task instructions compared with younger adults.
In Experiment @number@ participants completed a lexical decision task that presented words in the fovea and parafovea in both visual fields.
In Experiment @number@ participants evaluated each voice on various acoustical dimensions and speaker characteristics.
In Experiment @number@ participants found it easier to use temporal pattern information than statistical information provided as a result of interventions.
In Experiment @number@ participants had to alternate between the episodic memory task and a semantic task requiring a natural / artificial decision.
In Experiment @number@ participants read two types of sentences , one of which contained a doubly center embedded relative clause.
In Experiment @number@ participants received monetary consequences for meeting an increasing series of step goals on at least @number@ days during consecutive 5-day blocks.
In Experiment @number@ participants received the specificity induction or a control induction prior to the memory , imagination , and description tasks.
In Experiment @number@ reducing study time in younger adults decreased associative recognition performance , but did not produce a discrimination advantage for CW pairs.
In experiment @number@ SOL exhibited the highest shear modulus ( @number@ ± @number@ kPa ) .
In Experiment @number@ source decisions following old / new judgments were more accurate for repeated relative to non-repeated visually and auditorily learned names.
In Experiment @number@ subjects had to discriminate the walking direction of upright and inverted point-light walkers in a cloud of randomly moving dots.
In Experiment @number@ temporal correspondence was disrupted by limiting the lifetimes of the moving surface points.
In Experiment @number@ TGW recognition was assessed in quiet and in noise among adults of various ages with normal hearing to moderate hearing loss.
In Experiment @number@ the contrast between the isolated item and background items was increased by isolating numbers in a list of words.
In Experiment @number@ the cue remained present upon target onset.
In Experiment @number@ the cue was presented briefly and removed prior to target onset.
In Experiment @number@ the movement error and variability were greater for older adults during the visual feedback trials when compared with young adults.
In Experiment @number@ the negative effect of age upon 3-D shape discrimination from motion was replicated.
In Experiment @number@ the participants haptically judged the shape of large ( @number@ cm diameter ) surfaces with an entire hand.
In Experiment @number@ the task was a font discrimination task ( nonlexical ) with foveal and parafoveal presentation in both visual fields.
In Experiment @number@ the two tasks were instead performed in separate blocks.
In Experiment @number@ we applied an RMS contrast of @number@ corresponding to the mean contrast of HSF scenes in natural conditions.
In Experiment @number@ we confirm age-related differences in haptic 2D shape recognition , and we show the typical age × complexity interaction.
In Experiment @number@ we confirmed that 4- to 7-year-olds chose a hook tool to retrieve a bucket from a tube.
In Experiment @number@ we found that new association priming is age invariant , regardless of spatial contiguity.
In Experiment @number@ we induced simultaneous opposite age aftereffects for female and male faces.
In Experiment @number@ we manipulated four levels of linearly-increasing RMS contrasts ( @number@ @number@ @number@ and @number@ ) for HSF scenes only.
In Experiment @number@ we observed less head motion during a memory encoding task than during the resting-state condition.
In Experiment @number@ we omitted the old / new decision to more directly test fast-acting fluency effects on source memory.
In Experiment @number@ we provide additional evidence that pictorial association priming is perceptually based.
In Experiment @number@ we replicated the pseudohomophone effect in beginning readers and we tested how orthographic knowledge may modulate this effect.
In Experiment @number@ we replicated this age-related deficit in sensitivity to positive emotion , as well as evaluated possible explanations for it.
In Experiment @number@ we target the last step in the model ( matching and naming ) for complex stimuli.
In Experiment @number@ we used a more sensitive response time measure to show faster T2 discrimination at shorter lags in the nonaging condition.
In Experiment @number@ when younger adults ' encoding time was reduced , age differences were largely absent.
In Experiment @number@ with distractors presented as abrupt onsets , we replicated Maylor and Lavie's ( @number@ ) effect.
In Experiment @number@ young adults showed both early and late isolation effects , while older adults showed only a late isolation effect.
In Experiment @number@ young and older adults completed a cued recall task with integrative , semantic , and unrelated word pairs.
In Experiment @number@ young and older adults ' JOLs were sensitive to negative words ( higher JOLs for negative than neutral words ) .
In Experiment @number@ young , middle-aged , and older adults read sentences for delayed recall using a moving-window method.
In Experiments @number@ and @number@ older adults had greater implicit memory for irrelevant information than younger adults did.
In Experiments @number@ and @number@ participants observed a series of interventions on the system , which in these experiments operated deterministically.
In Experiments @number@ and @number@ when participants were able to rely on semantic knowledge , age-related differences in memory performance were eliminated.
In experiments with fragmented images , we found an improvement in image recognition with observers ' age , increasing up to 13-14 years.
In exploratory analyses , associations with three site-specific cancers : breast , prostate and colorectal cancers were also examined.
In exploratory analyses , we examined the effect of hormone replacement therapy ( HRT ) .
In exudative AMD , PPARγ agonists downregulate inflammation and the WNT / β-catenin pathway.
In eyes with age-related cataract , lens thickness increased with an increase in cortical opacity , whereas the ACD and ACV values decreased.
In face- and neck-lifting , such marks extend vertically to the neck.
In fact after RSV pretreatment , in response to CHP stress , glutathione content did not decrease as in unprotected samples.
In fact , age has always represented an exclusion criterion for eligibility to clinical trials.
In fact , Alzheimer's disease is a complex multifactorial disease.
In fact , a mutant mouse model of retinal degeneration shows an abnormal subcellular localization of SIRT1 protein and accelerated retinal cell apoptosis.
In fact , as discoveries are being made it is becoming clear that the findings across studies that appear contradictory are not contradictory at all.
In fact , aspirin does not inhibit isoprostane formation.
In fact , bone derives its fracture resistance with a multitude of deformation and toughening mechanisms that are active at most of these dimensions.
In fact , both LH and non-SHBG testosterone levels were lower ( P < @number@ ) in older men receiving testosterone treatment.
In fact , chronic wound patients frequently suffer from \ "highly branded \ " diseases such as diabetes and obesity.
In fact , CMA activation seems to be a common mechanism of cellular defense against proteotoxicity.
In fact , destruction of mitochondria , by oxidation of a dynamic-like transporter protein , may cause synapse loss in AD.
In fact , elevated saturated fatty acids could have negative effects on age-related cognitive decline and mild cognitive impairment ( MCI ) .
In fact , ER stress is a common feature of most neurodegenerative diseases.
In fact , erythroid lineage cells comprise the largest cell population in the fetal liver , and hepatocytes are distributed among the erythroid cell clusters.
In fact , hernia repair is the most common surgical procedure performed worldwide.
In fact , HIV infection is believed to hasten the aging process.
In fact , human clock properties measured in peripheral cells such as fibroblasts closely mimic those measured physiologically and behaviorally in the same subjects.
In fact it has been suggested that chronic CMV infection is a driving force in age-related T cell immunosenescence.
In fact , local resection has lower morbidity and mortality , with a comparable outcome.
In fact , many of the adverse outcomes of frailty are probably mediated by sarcopenia.
In fact , many older individuals increasingly expect to maintain reasonably high activity levels throughout their lifespan as well as after musculoskeletal injury.
In fact , neither expression rate nor activity of this protein was changed.
In fact , overall phosphorylation of tau was reduced , perhaps due to reduced microtubule binding.
In fact , patient satisfaction scores varied widely across the surveyed groups.
In fact , preclinical studies and clinical observations in humans have demonstrated age-associated alterations in antitumor immunity.
In facts , this pathway is implicated from the early steps of somitogenesis and the development of skeletal muscles in the embryo.
In fact , swollen , disrupted mitochondria and intracellular protein aggregates accumulate within affected motor neurons.
In fact , the cardiovascular disease mortality rate among women exceeds the rate in men.
In fact , the carriers of rs1800849 T allele showed higher hand grip than the remaining of the population.
In fact , the influence of snacking likely varies with different target populations.
In fact the intersection of aging and disability has been largely underexplored in both social gerontology and disability studies.
In fact , the number of diabetic patients in China is estimated to rise to @number@ million in @number@ from @number@ million in @number@
In fact , the one-third maintenance dose led to additional myofiber hypertrophy in the young.
In fact , the problem persists even beyond the simple Gompertz mortality law.
In fact , the prognosis is not certain , due to the possible recurrence , especially if not completely excised.
In fact , the rebound was significant only for working memory.
In fact , the risk of hip fractures in the elderly is associated with numerous bone features that degrade bone strength.
In fact , the underlying mechanisms are poorly understood.
In fact , this pathway is one of the major protein degradation mechanisms in eukaryotic cells.
In fact , this process could explain approximately @percent@ of the cases of low back pain in humans.
In fact , very little is known about covariations in spousal affect and aches as couples engage in their daily routines and environments.
In fact , vessel wall stiffening , and microcirculatory endothelial dysfunction , precedes hypertension and thus underlies the development of vascular disease.
In fact , whey protein has been found to stimulate muscle protein synthesis to a greater degree than other proteins such as casein and soy.
In falciparum malaria , angiopoietin-2 increased with age , independent of parasite biomass ( histidine-rich protein @number@ [ HRP2 ] ) .
In familial cases with more than @number@ years of onset age , dementia was most prominent ( @percent@ ) .
Infant crying data were obtained from validated behaviour diaries ; sleep-waking data from standard parental questionnaires.
Infantile amnesia , the inability of adults to recollect early episodic memories , is associated with the rapid forgetting that occurs in childhood.
Infantile-onset MG ( 0-4 years ) accounted for @percent@ in @number@ and was still as high as @percent@ in @number@
Infant length , weight , and head circumference were measured and z scores were calculated.
Infant leukaemia is an embryonal disease in which the underlying MLL translocations initiate in utero.
Infant relative disparity thresholds , unlike those of adults , were equal for vertical and horizontal disparities.
Infants ' age was found to affect the developmental curve of grandmothers' , but not mothers' , imitative behavior.
Infants and adults differ in the maturity level of their immune system and this results in distinct reactions to Gram-negative bacteria.
Infants born to Ob mothers did not have statistically significantly higher measures of inflammation or oxidative stress.
Infants receiving the HP formula had significantly higher serum urea and urea to creatinine ratios than did LP formula and BF infants.
Infants who developed BPD had significantly lower RV free wall PSS on days @number@ and @number@ ( P < @number@ and < 0.05 ) .
Infants with a right and left hand preference for object acquisition develop a right and left ( respectively ) hand preference for unimanual manipulation.
Infants with mild postnatal renal dilatation but without vesicoureteral reflux pose a challenge.
Infant TL was assessed in buccal cells at approximately @number@ months of age.
Infant weight was assessed at three and six months.
Infarction volume and neurological behavioral tests were performed after ischemia.
Infarct macrophages exhibit a proinflammatory M1 phenotype early and become polarized toward an anti-inflammatory M2 phenotype later post-MI.
In Fast , Young showed a trend for faster recovery ( @percent@ ; P = @number@ ) after anterior perturbations.
In fatty faces , a strip of fat is removed along the axial line to avoid bulging that can be seen through the skin.
Infected wounds with exposure of the tendons , bones , or points of articulation cannot heal in spite of bridging and local debridement.
Infection foci varied with different onset settings.
Infection-induced modifications of plasma acute phase proteins concentrations were not higher in low-grade inflamed than non-inflamed rats.
Infection is a devastating complication.
Infection is considered to be one of the most serious complications of CIEDs and carries a significant risk of morbidity and mortality.
Infection rate of tinea pedis is high in the elderly , wherein treatment by a dermatologist should be considered to prevent infecting their family members.
Infection-related diagnoses contributed to @percent@ of deaths.
Infections and bleeding could complicate course of illness and lead to rapid deterioration.
Infections and inflammatory conditions during pregnancy can dysregulate neural development and increase the risk for developing autism and schizophrenia.
Infections by these viruses have been detected in virtually all cervical cancers.
Infections in central nervous system may lead multiple damages in infected and neighboring cells.
Infection was present in @number@ patients ( @percent@ ) .
Infection with demodex happens through direct contact with infected bed linen , towels , creams and other cosmetics.
Infection with WNV is dependent on many factors including climate , mosquito habitats and immunologically naïve bird populations.
Infectious diseases are a global health burden and remain associated with high social and economic impact.
Infectious diseases are more prevalent in older people than in younger adults , and represent a major healthcare issue in older populations.
Infectious , musculoskeletal , nervous and circulatory diseases actively mobilize GP and nursing staff.
Infectious proteins ( prions ) are , ironically , defined by their resistance to proteolytic digestion.
In ( female ) adolescence , sensitivity to configural LSF cues is developed , which aids not only configural face perception but also face memorization.
In female bovids , annual horn growth increments may provide a record of age-specific reproduction and body growth.
In female CKD patients , SUA levels were associated with LVMI and LVH , whereas there was no association in male patients.
In female donors from all age groups the effect of beta-endorphin on neutrophil phagocyte activity was not observed.
In female mammals , bivalents are formed during fetal life and remain intact until shortly before ovulation.
In females , AMH is secreted by granulosa cells of small follicles in the ovary.
In females , IR dominant side strength was greater compared with IR on the nondominant side ( P < @number@ ) .
In females , loss of ovarian function results in decreased circulating estradiol.
In females LTL was furthermore associated with Vitamin D levels.
In females , no significant modification with aging was identified in LM and LMI.
In females , perceived activation demands increased the likelihood to work for pay a year later.
In females , the 5XFAD mice also showed @percent@ less total sleep than WT ( p < 0.01 ) .
In females , the association was not statistically significant.
In females with normal fertility , pre-antral ovarian theca cells respond to stimulation by inhibin B to provide androgen-based support for the developing follicle.
In female Tg mice , significant weight loss was observed at @number@ weeks and beyond , when compared with control wild-type ( WT ) mice.
Inferences were consistent with associations between these construct variables and the full SCREEN-II.
Inferential cut-off scores were estimated using a non-parametric technique and equivalent scores ( ES ) were computed.
Inferior parietal and supramarginal gyri were also affected bilaterally in AD as compared to controls.
Inferior turbinate tissues were discarded from patients undergoing partial turbinectomy.
Inferior vena cava filters could be used as alternatives to anticoagulant therapy for the prevention of pulmonary embolism when anticoagulation is either contraindicated or ineffective.
Inferring the causal involvement of telomeres in aging from current knowledge is therefore speculative and could hinder scientific progress.
Infertility is a major , multifaceted issue worldwide whose prevalence is increasing in both high- and low-income countries.
Infertility often has profound long-term or short-term impacts on the people involved and puts them at risk of familial and social pressures.
Infertility treatments have in the past almost exclusively only centered on the last two weeks of folliculogenesis , the gonadotropin-sensitive phase.
In fibrotic livers , the sinusoidal lining showed variable immunostaining for collagen IV.
Infiltrating ductal carcinoma is the most frequent histological type.
Infiltrating ductal carcinoma was the pre-dominant subtype in all the age groups.
In Finland , CERAD-nb was introduced in @number@ and has been proposed to be used in primary health care.
In fishes , as in other vertebrate species , the DNA component of the telomeres consists of the tandemly repeated TTAGGG motif.
In five mice each ( SAH and ADAMTS-13 groups ) , bleeding time was assessed @number@ h after SAH.
In five of these seven cases , the tumor involved the parotid gland.
In five patients with nephritic syndrome , the biopsies also showed several diagnoses.
Inflammaging , a state of chronic , low-level systemic inflammation , is a pervasive feature of human aging.
Inflamm-aging , i.e. chronic low-grade inflammation during aging , is commonly characterized by pro-inflammatory biomarkers.
Inflammaging is associated with many detrimental effects that combine to increase morbidity and mortality.
Inflammaging is both local and systemic , and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong.
\ "Inflammaging \ " refers to low-grade inflammation that occurs during physiological aging.
Inflammation and immune alterations have been linked to AD , suggesting that the peripheral immune system plays a role during the asymptomatic period of AD.
Inflammation , an integral component of homeostasis , is a complex tissue response to stressors that attempts to mitigate their effect and initiate healing.
Inflammation arising from various etiologies , including infection , autoimmune disorders , chronic diseases , and aging , can promote anemia.
Inflammation associated with any acute illness can lead to poor appetite and low food intake in older people.
Inflammation decreases after bariatric surgery , implicating it as a possible mechanism for cognitive improvement.
Inflammation has been associated with Alzheimer's disease ( AD ) and dementia.
Inflammation , in contrast , does seem linked to increase in physiological risk-but only among men , not women.
Inflammation-induced alterations in central nervous system ( CNS ) metabolism have focused on glutamate.
Inflammation interacts with processing and deposit of β-amyloid.
Inflammation in the aging brain increases risk for neurodegenerative disease.
Inflammation is a double-edged sword that can promote or suppress cancer progression.
Inflammation is a double-edged sword with both detrimental and beneficial consequences.
Inflammation is an adaptive response of the immune system to noxious insults to maintain homeostasis and restore functionality.
Inflammation is an essential protective part of the body's response to infection , yet many diseases are the product of inflammation.
Inflammation is a normal host defense reaction to infections and tissue injury.
Inflammation is an underlying basis for the molecular alterations that link aging and age-related pathological processes.
Inflammation is a prominent pathological feature of small vessel disease.
Inflammation is one mechanism that may link myosteatosis with increased T2DM risk , but studies examining the relationship between inflammation and myosteatosis are lacking.
Inflammation , kidney function , and frailty also seemed to be determinants of survival and recovery after an ischemic stroke.
Inflammation-mediated oncogenesis has been implicated in a variety of cancer types.
Inflammation occurs after HIV infection and persists , despite highly active antiretroviral therapy ( HAART ) .
Inflammation plays a critical role in the development , course , severity and outcomes of HF.
Inflammation plays a pivotal role in pathophysiological processes of kidney diseases.
Inflammation , regeneration and fibrosis are observed at the whole organ level , both in dystrophin-negative and dystrophin-positive portions of the chimeric tissues.
Inflammation regulates energy metabolism in both physiological and pathological conditions.
Inflammation was assessed as hsCRP and interleukin-6 levels.
Inflammation was assessed by the serum levels of high-sensitivity C-reactive protein ( hsCRP ) and interleukin ( IL ) @number@ and @number@
Inflammation was indicated by C-reactive protein and depression by the CES-D scale.
Inflammation was lower in the Canadian cities than in Manizales and Natal.
Inflammatory abnormalities were significantly associated with age in years , male gender , diabetes and the presence of knee joint symptoms.
Inflammatory bowel disease among the elderly is common , with growing incident and prevalence rates.
Inflammatory cells multitask at the wound site by facilitating wound debridement and producing chemokines , metabolites , and growth factors.
Inflammatory cytokines have been shown to prompt muscle wasting , ultimately stimulating protein catabolism and suppressing muscle synthesis.
Inflammatory cytokines may contribute to lower physical function in elderly.
Inflammatory cytokines , such IL-6 , TNF-α , IL-5 play the roles Muscle protein breakdown is up regulated through ubiquitin-dependent proteolysis.
Inflammatory cytokines were markedly increased in old control mice ( P < @number@ ) , but reduced to levels of young controls with nitrite supplementation.
Inflammatory lesions include erythematous and erythematous scaling , eczematous and urticarial lesions , vesicular and bullous lesions , and granulomatous lesions.
Inflammatory markers and plasma apolipoprotein levels were associated with poorer performance in the attention / processing speed domain.
Inflammatory markers ( CRP , tumor necrosis factor-α [ TNF-α ] , and interleukin-6 ) were obtained by enzyme-linked immunosorbent assay.
Inflammatory markers remained significantly associated with mortality.
Inflammatory markers were not altered.
Inflammatory mechanisms are activated in aging and late-onset neurodegenerative diseases , such as Parkinson's disease ( PD ) .
Inflammatory mechanisms play a central role in the pathogenesis and progression of atherosclerosis , plaque rupture , thrombosis , and stroke.
Inflammatory mediators and adhesion molecules were measured by multiplex analysis and gene expression was quantified by RT-PCR.
Inflammatory processes are dysregulated in sleep disturbance and also contribute to pain sensitivity.
Inflammatory processes are likely to play a causal role in geriatric depression.
Inflammatory response has been strongly implicated in the pathogenesis of numerous diseases , including Alzheimer's disease ( AD ) .
Inflammatory responses that are centralized within the brain and spinal cord are generally referred to as ' neuroinflammatory'.
Inflammatory signaling driven by the angiotensin II cascade perpetrates adverse age-associated arterial structural and functional remodeling.
Inflammatory signaling not only causes peripheral insulin resistance , but also promotes neuronal insulin and leptin resistance , which further propagates a positive energy balance.
Inflammatory signals generated within the brain and peripheral nervous system direct diverse biological processes.
Inflammatory ultraviolet-induced dermatoses have a confusing nomenclature and classification that often leads to difficulties in the differential diagnosis.
In flies , the male accessory glands make many major seminal fluid components.
Influenced by a special local environment , the proportion of centenarians is particularly high in some places , known as \ "blue zones \ ".
Influenced by processes , such as aging , the identification of an ' asthma microbiome ' presents a further challenge.
Influence of age , arterial hypertension , body mass index ( BMI ) and retinal microvascular abnormalities on the WLR was examined.
Influence of aging processes should be also taken into account.
Influence of confounding variables ( age , IQ , personality ) was minor.
Influence of sun exposure and physical activity on cognition has not been evaluated simultaneously.
Influencing factors were performed using multiple stepwise regression analysis.
Influencing some age-related conditions , such as frailty , may have an impact on the prevention of late-life cognitive disorders.
Influenza affects 5-15% of the population during an epidemic.
Influenza and its complications disproportionately affect the elderly , leading to high morbidity and mortality in this ever-increasing population.
Influenza A virus ( IAV ) causes an acute infection in humans that is normally eliminated by CD8
Influenza campaigns should be strengthened to increase vaccination coverage , especially in the group more reticent to vaccination.
Influenza exacts a heavy burden on the elderly , a segment of the population that is estimated to experience rapid growth in the near future.
Influenza infection is associated with high rates of complicated illness including pneumonia , heart attacks and strokes in the 65 + population.
Influenza infections are responsible for significant morbidity and mortality each year , with the highest infection rates found in the elderly population.
Influenza is a major cause of death in the over 65s.
Influenza is an important cause of morbidity and mortality in the elderly population each year.
Influenza is one of the most common infectious diseases afflicting humans , particularly the elderly.
Influenza vaccine remains the mainstay of prevention in transplant recipients , although immunogenicity of current vaccines is suboptimal.
Influenza-vaccines are effective , while vaccines with an adjuvance seem more immunogenic , in particular in older persons.
Influenza vaccine was inoculated at week @number@
Influenza virus and Streptococcus pneumoniae are two major pathogens that lead to significant morbidity and mortality in the elderly.
Influenza virus RNA-dependent RNA polymerase consists of three viral protein subunits : PA , PB1 , and PB2.
In following this knowledge production process , we explore how scientists \ "deliver \ " on their research proposal goals.
In follow-up analysis , TP ( g / kg / BW ) was inversely associated with LS BMD and LS BMC.
In followup , dependency incidence was @number@ per @number@ person-years ( CI @date@ @number@ ) and mortality was @number@ per @number@ person-years.
In food quality , increase of LFLP not only affects the appearance but also causes loss of nutritional value.
In forget-cued follicular women , salivary progesterone correlated positively with recalled list @number@ items.
Informal caregivers at risk remain , also in the future , women , spouses , migrants , and younger carers.
Informal caregivers play an increasingly important role in caring for aging Americans.
Informal caregivers reported higher rates and a higher level of severity of delusions and hallucinations than formal caregivers.
Informal care has frequently been neglected in health economic analyses , while in recent years its coverage has increased considerably in the international scientific literature.
Informal care is more frequent in small municipalities than urban areas and for those with than without cognitive impairment.
Informal care is non-financed care outside the realm of formal healthcare , which represents an increasing challenge for aging societies.
Informal filial care plays an important role for elderly parents facing health challenges.
In formal organisational settings , person-centred approaches place particular responsibility on ' empowered ' direct-care staff to translate these principles into practice.
Informant-based unawareness measures may be more subjective and less sensitive than variables taking into account actual performance on cognitive tests.
Informant-related memory questions were associated with global cognitive and functional decline and with diagnostic conversion over @number@ years.
Informant reports may challenge the finding that personality and PDs tend to \ "improve \ " over time.
Informants completed the MusEQ , and the OA group also completed the self-report version of the MusEQ.
Informants for these subjects reported whether or not they had ever received a clinical cognitive evaluation outside of the context of ADAMS.
Informants provided assessments of participants ' social functioning , personality , and social vulnerability.
Informants were asked whether the participant had ever received a doctor's diagnosis of dementia.
Information about activities and other variables were collected by structured interviews at baseline in the participants ' home.
Information about dose , route , and timing of administration of the opioid was frequently missing.
Information about duration of any and exclusive breastfeeding was obtained retrospectively by means of a parental questionnaire.
Information about interactions of chronic diseases can help to facilitate diagnosis , amend prevention and enhance the patients ' quality of life.
Information about molecular pathological subtypes of CRC was available for @number@ patients.
Information about mortality was obtained for @number@ patients aged @number@ and above.
Information about neurobehavioral and psychological symptoms , employment , education , and disability were also collected from the patient and a family member.
Information about osteoporotic fractures during the previous @number@ years was obtained from the Swedish National Patient Register.
Information about the QIs , the study sample , and specific setting was extracted.
Information about these driving behaviors should be given to drivers and their stakeholders and used to caution participants when implementing educational programs for older drivers.
Information and communication technologies are widely and rapidly spreading in people's daily lives.
Information and communication technologies ( ICT ) are promising for the long-term care of older and frequently frail people.
Information and communication technology ( ICT ) is needed for the implementation of integrated care in a medical systems approach.
Information collected included basic sociodemographics , cognitive status , urinary incontinence , and self-reported ability to do activities of daily living.
Information collected included exercise habits in middle age.
Information collected in survivors was based on history , physical examination of the cardiovascular system and Minnesota coding of resting electrocardiograms.
Information collected on socio-demographic , health behaviour and doctor diagnosed health conditions.
Information concerning maternal time spent in various interactive caregiving activities was collected when infants were @number@ months old.
Information concerning the effects of herbal medicines on mesenchymal cell osteogenesis and senescence remains lacking.
Information for the present study was obtained from the members of the @number@ British birth cohort ( n @number@ ) .
Information from about @number@ standardised questions and about @number@ analysed biomarkers needed to be documented per individual.
Information from @number@ patients who lived either at home or in geriatric health service facilities was collected for this trial.
Information from three observer-measured and three self-reported health indicators was combined , using a latent variable modeling approach.
Information highlighted by these scores is pertinent to the effort of Guide Dogs to ensure partnerships are lasting.
Information in the columns of the review matrix was used to compare the studies.
Information obtained from the parents was compared with World Health Organization standards.
Information on antidepressant use and incident dementia during follow-up was retrieved from electronic medical records.
Information on biomechanical exposures and job strain was collected by questionnaire at baseline.
Information on birth outcomes was retrieved from medical records.
Information on birth weight and ≥1 tests of intelligence was available for @number@ members of the cohort.
Information on cataract diagnosis and extraction was obtained through linkage to registers.
Information on childhood cognitive ability , educational attainment , vitamin D-related behaviours and other covariates was collected prospectively from participants throughout their life.
Information on clinical predictors was used to estimate the 10-year probability of hip and major osteoporotic fracture by FRAX ( version @number@ ) .
Information on comorbidities and permanent NH placement came from registries.
Information on co-morbidities , lifestyle factors , measured lipid parameters , and medications were collected during triennial visits.
Information on comorbidities , symptoms , screening tests , procedural outcomes , and follow up was obtained.
Information on consumer preferences will help in technology development to assist older adults to age in place.
Information on deaths until the end of @number@ was retrieved , providing a follow-up period of @number@ to @number@ years.
Information on demographic , health , and lifestyles factors was obtained by standardized questionnaire.
Information on demographics , comorbidities , and healthcare utilization was taken from an electronic medical record system.
Information on diagnosis-related grouping and length of stay ( LOS ) was obtained.
Information on diet was collected through an interviewer-administered , reproducible and validated food-frequency questionnaire.
Information on education and marital status was harmonized across cohorts.
Information on education was gathered using a questionnaire at age @number@ or @number@
Information on efficacy ( stool frequency and consistency ) was collected as a secondary outcome measure.
Information on hospitalizations was obtained from self- or proxy-report.
Information on ikigai was collected by self-reported questionnaire.
Information on incident heart failure was obtained during follow-up.
Information on lifestyle factors was not available.
Information on lifestyle habits , including physical activity , smoking and alcohol consumption , were obtained by a questionnaire.
Information on measured height and weight available in the two datasets was used to calculate Body Mass Index ( BMI ) .
Information on medical conditions and demographic factors was obtained from an institution-wide electronic medical record system.
Information on medication use was not available.
Information on memory function might better stratify mortality risk among persons with fast gait speed.
Information on mental disorders was obtained from Danish hospital registers with a mean follow-up interval of @number@.1years.
Information on mortality and cause of death was retrieved from registers for the period between @number@ and @number@
Information on nutritional knowledge was obtained from an interview based questionnaire for older subjects and caregiver and through self administered questionnaire from the health professionals.
Information on omega-3 and fish intakes was obtained by using a validated food-frequency questionnaire.
Information on pickiness was obtained from a parental questionnaire.
Information on psychosocial factors and other individual- and community-level factors was collected in the second half of @number@ using a baseline questionnaire.
Information on risk factors of colorectal cancer was obtained in standardized interviews.
Information on school performance , formal education , and occupational attainment was collected prospectively from elementary school archives and population censuses.
Information on smoking , drinking , and various covariates was obtained using self-administered , structured questionnaires.
Information on smoking habits , iris colour , diabetic status , and ethnicity were recorded.
Information on sociodemographic and reproductive characteristics and menopausal symptoms were also collected.
Information on sociodemographics and social relationships were assessed using standard questions.
Information on suicide as a cause of death was obtained from the National Death Index.
Information on tea consumption and HRQOL assessed by the European Quality of Life-5 dimensions ( EQ-5D ) were collected by questionnaires.
Information on the incidence of these lesions and association with cognition and dementia from longitudinal population studies is scarce.
Information on the influence of gender in motor performance is less well-established.
Information on their HbA ( 1c ) levels was collected at onset and every year thereafter.
Information on the subjects ' lifestyles and disease histories were obtained using a structured questionnaire and confirmed by clinical records.
Information on the use of concurrent OTC medications ( herbal medicines , dietary supplements , or non-prescribed drugs ) was elicited during home visit interviews.
Information on transcriptional regulation of the klotho gene and posttranslational modifications of the protein resulting in multiple forms of Klotho is reviewed.
Information on type of HT was only available from 1995-1998 ( Prescription Register ) .
Information on whether human retinal Müller cells suffer from oxidative stress with normal aging is lacking.
Information processing speed and decision making were assessed with the Trail Making Test and the Object Alternation task , respectively.
Information regarding age , duration of FA exposure and smoking habits was obtained by a questionnaire.
Information regarding any taken medications including psychiatric and antianxiety drugs was collected.
Information regarding deaths was available for the whole sample.
Information regarding demographics , comorbidities , and health-related behaviors was obtained via interview.
Information regarding demographics , nutritional status , medical history and medication usage was obtained.
Information regarding possible risk factors was collected using standardized telephone interviews.
Information regarding ubiquitin proteasome systems ( UPSs ) , specifically of K6 in ubiquitin , is undeveloped.
Information related to neural networks has elucidated the nonlinear dynamical complexity in brain signals over a range of temporal scales.
Information seeking was assessed with the use of an item asking caregivers if they ever looked for caregiving-related information.
Information technology ( IT ) and serious games allow older population to remain independent for longer.
Information technology ( IT ) use for health matters was positively associated with formal social participation for women and with informal social participation for men.
Information technology solutions may ease the burden placed on LDCs by providing remote monitoring , easier access to information and enhanced communication.
Information was also obtained from International Plant Names Index , Chinese Pharmacopoeia , Chinese herbal classic books , PhD and MSc dissertations , etc.
Information was also retrieved from medical records.
Information was collected about their participation in strenuous and moderate activities between high school and menopause.
Information was collected from resident questionnaires , housing managers data , and medical information.
Information was collected on lifestyle , medical history , medication use , and a non-fasting blood sample was drawn.
Information was collected on lifestyle , past and current diseases , medical history and medication use.
Information was collected over the course of the SAH program every @number@ months from @date@ through @date@ .
Information was extracted on study design ; population ; therapy ; comparison groups ; outcome ( s ) ; main findings.
Information was gathered on sociodemographic characteristics ; disability , dependency and frailty ; use of health services ; and characteristics of care and caregiver burden.
Information was obtained from computerized clinical records and by telephone survey.
Information was obtained on demographic characteristics , social resources , health conditions and behaviors , health service use , and physical inactivity.
Information was obtained on socio-demographic and clinical characteristics through face-to-face interviews using a structured questionnaire , and anthropometric and biochemical measurements were performed.
Informative cues resulted in increased performance after a spatial change in target talker compared to uninformative cues , not indicating the future target position.
Informative loss to follow-up may bias the results of these studies.
Informed consent and Human Subjects Committee approval were obtained.
Informed patient decision making about treatment options , adverse effects and outcomes can have a beneficial impact on medication-taking behaviour.
In forward reach ( FR ) , reaching was performed during quiet standing.
In four of seven primate species we found that reproductive senescence occurred before death only in a small minority of individuals.
In frail elderly or individuals with a short life expectancy , it may be reasonable to maintain HbA1c between @number@.6%-8.5%.
In frail elders there was also a higher prevalence of underdiagnosed dementia.
In frail older men with low testosterone levels , testosterone therapy appears to improve QOL and physical function.
In Framingham Offspring Study participants most CHD cases had LDL-C levels above the recommended target.
In France and the UK , pictorial warning labels were implemented on the back of cigarette packages between the two survey waves.
In France , the reimbursement by the society of a technique with very low results is discussed.
Infrared ( IR ) radiation is electromagnetic radiation with wavelengths between 760nm and @number@ , 000nm.
Infrared spectrum analysis indicated that there were C-H , C = O and -CH2 bonds in MPS and MZPS.
In free recall but not forced-choice recognition , the emotion-focused orientation increased young adults ' positivity bias and thus wiped out their superior negativity bias.
In frontotemporal dementia ( FTD ) , the stereotypical behaviors may be associated with time.
In FTD , cognitive medication use was associated with elevated NPI elation scores and psychiatric medication use was associated with history of prior psychiatric disease.
In fully adjusted analyses , LS with health , housing , and recreation predicted death.
In fully adjusted models , current smokers with 21-40 pack-years scored @number@ points lower ( @number@ % CI @number@ to @number@ ) than never-smokers.
In fully adjusted models OI remained related to slowness and low muscle strength and to higher FI scores.
In functional experiments , Pin1 proved to be a main regulator of FOXM1 activity through MEK-dependent physical regulation during the cell cycle.
In functionally declined , community-dwelling , older persons a complex intervention for reducing fall risks was effective compared with usual care.
In functional magnetic resonance imaging ( fMRI ) research one is typically interested in neural activity.
In functional studies , miR-9 interacted with the @number@'UTR of SIRT1 mRNA.
In further approaches , whole mitochondria have been transferred into recipient cells.
In further contrast , previous datasets have been presented in tabulated form , which is impractical for spatially-dense data.
Infusion of MBG seems to directly contribute to increased nitrative stress and cardiac fibrosis.
Infusion of neuronal exosomes into brains of APP transgenic mice decreased Aβ and amyloid depositions , similarly to what reported previously on neuroblastoma-derived exosomes.
Infusion-related reactions and neutropenia were more common with obinutuzumab-chlorambucil than with rituximab-chlorambucil , but the risk of infection was not increased.
In future , dental professionals must have a proper understanding of the magnitude of the services to be provided to the elderly.
In future , metabolic phenotyping should focus on the EE-FFM relationship rather than on EE-values alone.
In future , prevalence of exercise habits may lead to decrease the prevalence of locomotive syndrome , resulting in elongation of the healthy life span.
In future research , both the sources ( cues ) and behavioral effects of age-related differences in the discrimination of positive expressions should be investigated.
In future research , cost-effectiveness analyses should be considered for evaluating novel cardiovascular risk assessment strategies.
In future research , investigators should further examine the subgroup effects observed.
In future studies a combined analysis of PF and IFB may help to specify deviations in developmental disorders.
In future studies , the mode of MNA application in nursing home residents should be clearly stated to facilitate comparability of results.
In future , treatment of these patients might take their potential for pro-active cooperation more strongly into account than it is currently the case.
In future vaccine trials , timing of vaccination and sample collection should be recorded carefully to allow for its use as a study covariant.
In GBS patients , the γ-tocopherol concentration correlated positively with concentrations of δ-tocopherol , α-tocopherol , lutein , Q10 , and γ-CEHC , respectively.
In GD , patients diagnosed in the area with more severe iodine deficiency had lower levels of T3 and T4.
In general across the SABE cities , the elderly with the most missing teeth were less educated or less likely to be a professional.
In general , actinomycosis responds well to antibiotic therapy , but long-term follow-up after treatment is needed because of frequent relapses.
In general , activities of cytochrome P450 enzymes are preserved in normal ageing and the genetic influence is much more striking than age effects.
In general , aging is associated with a decline of cognitive functions.
In general , aging was associated with decreased force steadiness and force complexity with a concomitant increase in bilateral PFC activity.
In general , based on the work described here we propose a model in which ROS function as stem cell rheostat.
In general , bone histomorphometric analyses indicated significantly lowered osteoblasts and osteoclasts numbers and surfaces on vertebrae of EE2-fed medaka.
In general , common genetic variants associated with telomere length homeostasis have been difficult to detect.
In general , development and aging are conventionally studied separately , which may not completely address the physiological mechanism over the entire lifespan.
In general , food shopping was perceived to be a manageable but mundane part of life.
In general , gender difference in help seeking and receiving treatment increases with younger age.
In general , gender differences in relation to stroke are increasingly being recognized and evaluated.
In general , gingival margins showed more microleakage than occlusal margins.
In general , highly cognitively and physically functioning hip fracture patients demonstrated higher vitamin E concentrations.
In general , individuals with disability did not experience an age-related decrease in pain and pain impact in contrast to those in the normative sample.
In general , it is important to separate episodic memory during social interaction from episodic memory during the self-generation of action events.
In general , liposomal cytarabine was well tolerated , with relevant but manageable toxicities.
In general , local norms were more stringent than published norms.
In general , nurses from the outset were positive regarding pain assessments.
In general older adults , even the oldest old are community dwelling and vital.
In general , older patients have a higher risk of postoperative adverse outcomes , and frailty is a very important risk factor.
In general , older subjects performed less accurately and showed an increased inversion effect.
In general , outcomes of GT placement in patients with progressive diseases that develop during childhood are not well characterized.
In general , patterns of atrophy in the pseudolongitudinal analysis largely recapitulated Braak staging of NFTs within the MTL.
In general population , its prevalence is 1 : 600-1 : 800 live births.
In general , postural control was impaired , indicated by an increase in parameters quantifying body sway , when using psychotropic FRIDs.
In general , prevalences of most chronic conditions increased with age.
In general , senescence can be divided into replicative senescence and premature senescence.
In general , some evidence exists suggesting that a biological mechanism extending from the sex hormones influences activity in humans.
In general , sonography revealed that facet joints had a clear and smooth border.
In general , steps / day tended to decrease within each quintile-defined category as age increased.
In general , studies have focused on their presence in the upper limb , which is used in the majority of daily activities.
In general , temperature measurement is an insensitive method to identify geriatric patients with infection.
In general , testosterone concentration is elevated directly following heavy resistance exercise in men.
In general , the apical and basal twist increases during the aging process , leading to an increased LV twist value.
In general , the causes of nocturia fall into three categories : diurnal polyuria , nocturnal polyuria , and low bladder capacity.
In general , the existing approaches to this problem use appearance features only.
In general , the failure pattern appeared at the resin / bracket interface or within the resin.
In general , the hypothesis of dementia prevention by risk factor control at a population level needs to be established.
In general , the indexes showed poor to fair discrimination accuracy.
In general , the naMCI volunteers showed a level of disturbed sleep that was intermediate to that of aMCI and intact volunteers.
In general , the @number@ groups followed parallel trajectories and were differentiated mainly by differences in AFQT performance level at the time of military induction.
In general , the obtained results prove that the ageist assumption that the geriatric patients are troublesome is not arguable.
In general , the plantarflexors had a stronger predictive role than the dorsiflexors.
In general , there is an association between glutathione depletion and Parkinson's or Alzheimer's disease.
In general , the relations are weak , and not all subjects with SVD become demented or get parkinsonism.
In general , the relationship between PEP and mastery does not vary whether PEP relative to peers or PEP relative to American families is examined.
In general , the reported motivations for BS use were not supported by clinical evidence.
In general , there was an efficient and tumor-selective abrogation of cell survival in suspension or protective stromal-cell cultures.
In general , there was no significant difference between estimates of perceptual and body motion thresholds.
In general , there were decreases in SOS over increasing age groupings.
In general , these changes in warning label responses did not differ by education.
In general , these values are widely distributed for smaller samples and the distribution narrows as n increases a pattern expected from sampling theory.
In general , the total length of life also increased the probability of the evolution of cooperation.
In general , the treatment of IBS in the elderly is not different from the younger populations.
In general , they were not satisfied with the financial and working conditions of the recent Hungarian healthcare system.
In general , those who performed worse on the UFOV and TIADL at baseline demonstrated significantly more training gains.
In general , thyroglobulin serum concentrations higher than @number@ microg / l should be an indicator for determining urinary iodine.
In general , unexpected and rare AEs could be attributed to incorrect treatment technique or classified as unrelated to MFU-V treatment.
In general we observe a large number of instances of positive selection acting on telomere genes.
In general , women suffered from higher rates of multimorbidity and poorer results in quality of life and disability.
In general , women survived longer than men did regardless of whether they were ADL disabled or not.
In genetic studies of complex behavior , which require particularly large samples , such trait measures can serve as endophenotypes.
In genotype @date@ patients , grazoprevir / elbasvir is least favorable as @percent@ of the patients must alter their cART.
Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
In geriatric patients this improvement was relevant for HRQoL only.
In German men and women , absolute SMM and FFM were higher than in their Japanese and Brazilians counterparts.
In Germany and the Netherlands , the text warning labels did not change.
In Germany , approximately @number@ TAVI procedures were performed in @number@ and even more are expected in @number@
In Germany there are @number@ million people with a migration background , one in five of the total population.
In Germany transcatheter aortic-valve implantations ( TAVI ) procedures are reimbursed according to a DRG number.
Ingested , injected , inhaled and decompartmentalized iron contributes not only to disease , but also to aging and mortality.
Ingested RESULTS : Leucinemia was higher with Leu treatment than with placebo treatment ( P < @number@ ) .
Ingestion of ACPs significantly alleviated UV-induced abnormal alterations of skin components and antioxidative indicators in both serum and skin ( p < @number@ ) .
Ingestion of EAAs ( or protein ) shortly after resistance exercise enhances MPS and mTORC1 signaling compared with resistance exercise or EAAs alone.
In GG-homozygotes , severe working memory dysfunction occurred already in middle age.
In girls , smaller left amygdala volumes were associated with better emotional control.
In girls , the same is seen only for T starting from BA @number@ to @number@ whereas W and L grow at a declining rate.
In Gironde ( France ) , where a specialized registry has been established , the annual incidence of glioblastoma is @number@.96 / 100 , 000.
In glaucoma patients , lamina cribrosa depth changes are detected with similar frequency as neuroretinal parameter changes.
In glucocorticoid-induced osteoporosis , there is no significant difference between Zol and risedronate for new fractures.
In Gombak district and Guangzhou , emmetropia was a minor category at all ages , with myopia increasing as mild hyperopia decreased.
In good-quality embryos , CKB expression was higher in the cumulus cells acquired from both older and younger age groups than in poor-quality embryos.
In grades 1-2 , children's ability to judge the relative magnitude of numerical symbols was most predictive of early arithmetic skills.
In Group A , OC and ucOC decreased by @percent@ and @percent@ , respectively ( P < 0.001 ) .
In Group M , OC and ucOC decreased from baseline by @percent@ and @percent@ , respectively ( P < 0.001 ) .
In Group @number@ age , Charlson comorbidity index score , and number of patients with poor / very poor appetite were significantly higher.
In group @number@ DC density was higher in patients taking preserved drugs than in those taking preservative-free drugs ( P < @number@ ) .
In group @number@ @number@ of @number@ patients completely lost the ability to frown and @number@ patients ( @percent@ ) suffered permanent sensory loss.
In Group @number@ @percent@ were deceased during follow-up period.
In group @number@ serum OSI levels were significantly correlated with age ( r = @number@ p = @number@ ) .
In group @number@ the changes were weaker but significant ( p = @number@ ) .
In groups of subjects over @number@ years of age , numerous Aβ diffuse plaques were scattered throughout the cerebellar cortex.
In Groups T and U , failures occurred due to bending of the implant neck.
In growing rodents , RES increased longitudinal bone growth , but had no other effects on bone.
In habitual exercisers , these effects of aerobic exercise on sleep , although modest , might counteract those resulting from aging.
In haemodialysis patients , acid ( CMPF ) levels were markedly higher and BUN and uric acid borderline lower in the older age-group.
Inhalation of molecular hydrogen ( H2 ) gas ameliorates oxidative stress-induced acute injuries in the brain.
Inhalation of recombinant STC1 shows the same effects as the injection of MSCs.
Inhalation of the isoflurane anesthetic leads to opening of the mitochondrial permeability transition pore and loss of mitochondrial membrane potential.
Inhaled corticosteroids in combination with long-acting bronchodilators can reduce the frequency of exacerbations , and supported self-management aims to facilitate timely treatment of deterioration.
Inhaled long-acting bronchodilators including beta2-agonists and anticholinergics for COPD would not worsen HF.
In half the trials , the path was obstructed with hanging obstacles.
In harsh conditions , Caenorhabditis elegans arrests development to enter a non-aging , resistant diapause state called the dauer larva.
In HA-treated patients , erythema and inflammation , swelling , and pain were most frequent.
InhB concentrations are highest in the follicular phase of the cycle.
In HD , boundaries of motor age-at-onset based on diagnostic confidence or derived from the TMS data cut-off in controls were similar.
In HD patients , IDL apoB levels were elevated , but LDL apoB levels remained within the normal range.
In HD patients , large HDL subfractions are more abundant while small HDL fraction is more frequent in healthy persons.
In head-to-head comparison studies , TPF50 showed the best efficacy in reducing all of the three molecular markers.
In health care settings , incontinence-associated skin maceration is highly prevalent in the elderly.
In health individuals , acute increase in uric acid results in an increased IL-6 response when challenged with lipid load.
In healthy cell , inappropriate accumulation of poor or damaged proteins is prevented by cellular quality control system.
In healthy Chinese subjects , gustation was normal and did not vary with age.
In healthy controls , aging was negatively correlated with midsagittal area of the midbrain and midbrain / pons values.
In healthy controls , no sensitization to components of hazelnut , hazel pollen or birch pollen was demonstrable.
In healthy controls , reach variability increased as the probability of reward decreased.
In healthy elderly , high body mass index and waist-hip ratio predicted increased Qalb @number@ years later.
In healthy humans , lymphocyte populations are maintained at a relatively constant size throughout life , reflecting a balance between lymphocyte production and loss.
In healthy males plasma alpha-synuclein levels correlated strongly with age , revealing much lower concentrations in older ( avg.
In healthy older adults , MPOD was only related to visual-spatial and constructional abilities ( p = @number@ ) .
In healthy organisms the metabolism of the trace element zinc is well balanced.
In healthy subjects , hemodynamic changes in either organ may affect hemodynamics of the other organ.
In healthy subjects , it appears that overall PA is beneficial , rather than detrimental , to knee joint health.
In healthy subjects or in individuals with the MetS , the results are too heterogeneous and scarce to be able to set any specific recommendations.
In healthy volunteers the percentage of multistep saccades and the mean saccade latency increase significantly after the age of @number@
In heat-shocked cells , c-Jun-mediated gene expression was induced slowly following accumulation of c-Jun protein.
In HEK293 cells HP produced nuclear translocation of β-catenin , together with a reduction in Klotho.
In HEK293 cells , protein levels were determined by western blotting.
In HEK-293 cells , α-synuclein and its all PD-associated mutants destabilize the microtubule cytoskeleton in a similar extent.
In HEK-APP cells , DHA significantly increased membrane fluidity and non-amyloidogenic processing of APP , leading to enhanced secretion of sAPPα.
In HeLa cells , JUN transcription was rapidly induced by heat treatment.
Inherent color instability of nonpigmented facial silicone elastomers primarily contributes to the color degradation of extraoral facial prostheses.
Inherent in these two domains are mutable factors suitable for targeted efforts to promote older adult health and well-being.
Inherent node-strength was related to local iron ( F ( @number@ ) = @number@ p < @number@ ) .
In hERG-HEK293 cells , urocortin2 reduced rapidly activating delayed rectifier potassium current density which may contribute to action potential duration prolongation.
In her inaugural speech Alice de Boer discussed social inequality as possible determinant and outcome of informal care.
Inherited mutations in genes related to BER can give rise to disorders involving cancer , immunodeficiency and neurodegeneration.
In HGPS ( but not atypical Werner syndrome ) , extensive loss of vascular smooth muscle cells leads to myocardial infarction with premature death.
Inhibited AChE can be reactivated by cleavage of the Ser-phosphorus bond either spontaneously or through a reaction with nucleophilic agents , such as oximes.
Inhibiting expression of eukaryotic translation initiation factor 4G ( eIF4G ) arrests normal development but extends lifespan when suppressed during adulthood.
Inhibiting JAK in omental preadipocytes decreased chemokine secretion and macrophage / monocyte chemoattraction to levels closer to that observed in subcutaneous preadipocytes.
Inhibiting MS4A6A may therefore promote a more neuroprotective phenotype , although further work is needed to establish whether this is the case.
Inhibiting nestin phosphorylation at these two sites may represent a novel therapeutic strategy for pancreatic cancer.
Inhibiting p27 protein degradation is an actively developing cancer therapy strategy.
Inhibiting the B-cell receptor pathway seems of particular importance in effective targeted therapies of CLL.
Inhibiting the cAMP effector protein Epac prevents SRT1720 from activating AMPK or Sirt1 in myotubes.
Inhibiting the PPP in neuronal cell models causes cell death.
Inhibiting β-secretase activity is believed to be one of the most promising strategies for AD treatment.
Inhibition of 11βHSD1 may have therapeutic potential in sarcopenia.
Inhibition of AEP may be therapeutically useful for treating tau-mediated neurodegenerative diseases.
Inhibition of Akt-1 led to a decrease of ribosomal gene expression and the mitochondrial DNA content in both human cells and nematodes.
Inhibition of Akt-mTOR signaling protects from obesity and extends life span in animals.
Inhibition of amyloid-β generation with β- or γ-secretase inhibitors not only decreased amyloid-β pathology , but also attenuated tauopathy.
Inhibition of CaMKII by KN-93 ( CaMKII-specific inhibitor ) , reduced HR without significant changes in other parameters.
Inhibition of CS glycosyltransferase gene expression may reduce CS chain length , which may contribute to OA progression.
Inhibition of DDR restored satellite cell differentiation ability.
Inhibition of either one of these enzymes ablates 7KCh-fatty acid ester ( 7KFAE ) formation.
Inhibition of endogenous dentin matrix metalloproteinases ( MMPs ) within incompletely infiltrated hybrid layers can contribute to the preservation of resin-dentin bonds.
Inhibition of GGTase-I in vitro modeled the effects of aging we observed in vivo.
Inhibition of glucocorticoid receptor-associated Src kinase also produced a decrease in cortisol-induced RNS.
Inhibition of hepatic BACE1 activity in middle-aged humans would produce effects not detectable in mice.
Inhibition of HIF-1α by siRNA , HIF-1α-dominant negative or by zinc re-established the HIPK2 levels and the p53-mediated chemosensitivity in tumor cells.
Inhibition of HO-1 by tin protoporphyrin IX exacerbated autophagy and mitochondrial activity as well as cell viability in young cells.
Inhibition of hypothalamic Cbp results in profound obesity and impaired glucose homeostasis , increased food intake , and decreased body temperature.
Inhibition of miR-130a reversed liver size enlargement induced by Hippo pathway inactivation and blocked YAP-induced tumorigenesis.
Inhibition of MMP- @date@ present a preventive strategy for CAA-associated hemorrhage.
Inhibition of mTORC1 by rapamycin could still enhance activation-induced autophagy.
Inhibition of mTOR expression was established by small interfering RNA ( siRNA ) and mTOR inhibitors.
Inhibition of mTOR signaling by AZD8055 prevents BMS-777607-induced polyploidy / senescence and increases breast cancer cell chemosensitivity.
Inhibition of mTOR through rapamycin and caloric restriction promotes longevity.
Inhibition of NF-κB , or its downstream target Phospholipase A2 , in myofibers rescued muscle regenerative potential in aged muscle.
Inhibition of NOS reduced antegrade shear in the young such that age-related differences were abolished.
Inhibition of Notch signaling with a γ-secretase inhibitor attenuates hypoxia-enhanced SOCE in PASMCs and hypoxia-induced increase in pulmonary arterial pressure.
Inhibition of nutrient-induced expression of CAPER arrests nutrient-dependent cell proliferation and ATP generation and induces autophagy-mediated vacuolization.
Inhibition of PCSK9 also results in reductions of plasma lipoprotein ( a ) levels.
Inhibition of PIM-1 alleviated both replicative and oncogene-induced senescence.
Inhibition of Pin1 in animal models has profound anti-tumor effects.
Inhibition of prenylation has been extensively investigated to suppress the activity of oncogenic Ras proteins to achieve antitumor activity.
Inhibition of Rac1 activity significantly inhibited CEC transmigration without affecting PI-3K activity.
Inhibition of rapamycin-insensitive functions of mTOR further contributed to anti-hypertrophic and cytostatic effects.
Inhibition of return ( IOR ) is a phenomenon of attentional orienting that is indexed by slower responses to targets presented at previously attended locations.
Inhibition of RhoA , a Rho GTPase family member , is proposed to curb Aβ production.
Inhibition of RIPK3-MLKL-dependent necroptosis by FADD and caspase-8 was identified as a key mechanism preventing inflammation in epithelial barriers.
Inhibition of SHP2 also decreased the number of SSCs present in culture and caused SSCs to detach from supporting cells.
Inhibition of SIRT1 could be useful for cancer treatment while activators can be useful for longevity and treating metabolic disorders.
Inhibition of SIRT1 reduced deacetylation and promoted activation of p53 and p65 , leading to apoptosis and increased expression of proinflammatory genes.
Inhibition of SIRT7 with siRNA in cultured lung fibroblasts resulted in an increase in collagen and α-smooth muscle actin ( α-SMA ) .
Inhibition of SRD5A2 by finasteride is used commonly for the management of urinary obstruction caused by benign prostatic hyperplasia.
Inhibition of the AGE-RAGE axis by n-butanol extracts of noni may be a novel nutraceutical strategy for the treatment of cardiovascular disease.
Inhibition of these enzymes elevates biogenic amine levels in the synaptic cleft.
Inhibition of TRAF6 also blocks the expression of the components of the ubiquitin-proteasome system ( UPS ) and autophagosome formation in atrophying skeletal muscle.
Inhibitors of ABAD-Aβ interaction may hold promise as targets for the prevention and treatment of Alzheimer's disease.
Inhibitors of hFVIII were detected in four treated animals , further establishing the preclinical value of this model.
Inhibitors of histone deacetylase ( HDAC ) exhibit neuroprotective and neuroregenerative properties in animal models of various brain diseases.
Inhibitors of microsomal prostaglandin ( PG ) E synthase-1 ( mPGES-1 ) are being developed for the relief of pain.
Inhibitors of mTOR , including clinically available rapalogs such as rapamycin ( Sirolimus ) and Everolimus , are gerosuppressants , which suppress cellular senescence.
Inhibitors of oligomer formation , therefore , could be valuable therapeutics for patients with AD.
Inhibitors of oligomer formation , therefore , could be valuable therapeutics for patients with AD and LBD.
Inhibitors of this pathway might be developed for treatment of patients with NAFLD.
Inhibitors targeting these pathways have many potential uses from suppression of cancer , proliferative diseases as well as aging.
Inhibitory complexin-I explained @percent@ of the variance in global cognition in Braak @date@ , while excitatory complexin-II explained @percent@ of the variance in Braak V-VI.
Inhibitory processes and postural stability both deteriorate with age.
In high-income countries , avoidable male mortality has fallen since @number@ because of decreases in avoidable cardiovascular deaths.
In high-income countries , life expectancy at age @number@ years has increased in recent decades.
In highly proliferative tissues , replicative and premature senescence participate in determining senescent cell accumulation.
In hippocampus of 8-month-old AβPP23 mice , we observed increased EAAC1 expression besides the decrease in GLAST and GLT-1.
In HIV-infected individuals without CKD , eGFRSCR was higher than eGFRCYSC , whereas it was lower than eGFRCYSC in persons with CKD.
In HIV-infected men , older age , proteinuria , and prior clinical AIDS were inversely associated with both GFR estimates.
In HIV-infected patients a low CD4 : CD8 ratio can persist despite CD4 recovery with long-term antiretroviral treatment ( ART ) .
In HIV-infected patients , the level of inflammation and innate immunity activation is enhanced and related to most comorbidities and to mortality.
In HIV-infected persons , age is negatively associated with optimal CD4 recovery following antiretroviral therapy.
In HIV infection , patients aged ≥50 years have a poorer immunological response to HAART and a poorer survival.
In HIV interventions where testing is not possible , self-reported status should be considered as a routine first step to establish HIV status.
In HIV-positive patients , early cross-sectional imaging is warranted to detect uncommon disorders and complications , with the aim to preserve renal function.
In home medical care settings , triadic communications among the doctor , patient and the family are common.
In Hong Kong , suicide rates of young men have increased.
In-hospital and total survival times , number of deaths , and all-cause and CV mortality were registered until the census date on @date@ .
In-hospital complications included pressure ulcers and delirium , in @number@ and @percent@ of residents , respectively ; and up to @percent@ experienced potentially invasive interventions.
In hospitalized elderly patients with COPD , LV diastolic dysfunction should be taken into account together with right ventricular function.
In-hospital mortality rates were not significantly different between groups , even after adjusting for possible confounders.
In-hospital mortality was @percent@ and transfer to ICU @percent@.
In-hospital outcomes were investigated during a mean ± SD follow-up period of @number@ ± @number@ days.
In hospitals and in settings without on-site physicians , EHR use lagged in rural areas.
In H. pylori-negative subjects , NSAID users presented significantly shorter telomere length than nonusers ( p = @number@ ) .
In htau mice CSPalpha expression was found to be elevated at times when neuronal loss did not occur.
In HT , collagen deposition was already evident in youngest , with a further enhancement in the aged group.
In HT , nitric oxide availability is early reduced , but the progression rate with age is similar.
In HT-p21 cells , cell cycle arrest was caused by IPTG-inducible p21 and was spontaneously followed by mTOR-dependent geroconversion.
In human aging , the alterations depend on muscles and the habitual activity of each muscle.
In human aortic smooth muscle cells , low extracellular pH prevented osteogenic signaling.
In human cells , SUMO2 is predominantly conjugated to target proteins in response to cellular stress.
In human cells , there are four SUMO proteins , SUMO1-4 , with SUMO2 and SUMO3 forming a closely related subfamily.
In human cirrhotic liver , activated HSCs express high levels of class IIa HDACs but little CtsH.
In human colorectal cancer cells with APC mutations , PrxII depletion consistently reduces the β-catenin levels and the expression of β-catenin target genes.
In human cortex there was an increase of 5hmC of @percent@ , in white matter we found an increase of even @percent@ during ageing.
In human dermal fibroblasts , MβCD treatment induced up-regulated COL I and down-regulated Cav-1 , supporting the results of mouse experiments.
In human embryonic lung fibroblast cells , B-MYB downregulated p16 ( INK4α ) expression , whereas knocking down of B-MYB upregulated it.
In human epidemiology studies , the low-grade and chronic systemic inflammation in elderly has been correlated with the development of aging related pathologies.
In human islet cells soluble Klotho protected against cell death , and stimulated proliferation and insulin secretion.
In human lens proteins , advanced glycation endproducts ( AGEs ) originate from the reaction of glycating agents , e.g. , vitamin C and glucose.
In humans , aberrant expression of eIF4G is associated with certain forms of cancer and neurodegeneration.
In humans , aging is associated with telomere shortening and increased susceptibility to acute kidney injury.
In humans , Aß deposition in Alzheimer's disease overlaps with cortical regions highly active earlier in life.
In humans , BM plasma cells and their functions are less well characterized.
In humans , chemosensation mediates safety , nutrition , sensation of pleasure , and general well-being.
In humans , DNA methylation at specific CpG sites can be used to estimate the ' epigenetic clock' , a biomarker of aging and health.
In humans , empathy for others is facilitated by having had a similar prior experience.
In humans , frailty can be quantified using a frailty index ( FI ) based on the principle of deficit accumulation.
In humans , growth hormone ( GH ) is secreted from the anterior pituitary in a pulsatile pattern.
In humans , high dietary spermidine intake correlates with reduced blood pressure and decreased risk of cardiovascular disease and related death.
In humans , high homocysteine concentrations are an important predictor of age related disease.
In humans , however , the effects of CR or other life-extending agents have not yet been investigated systematically.
In human SH-SY5Y cells expressing MAO-A but not MAO-B , hypoxia significantly increased the MAO-A expression , which was blocked by M30 or clorgyline.
In humans , hypomethylation of IL-1β is strongly associated with chronological age and with elevated IL-1β transcription.
In humans , it is important to also consider differences in age-related decline that occur within and among tissues.
In human skin its expression is increased in wounds.
In humans , loss of RecQ gene function is associated with cancer predisposition and / or premature aging.
In humans , measurement of BER variation has been imperfect to this point , yet tools to assess BER in epidemiological surveys are steadily evolving.
In humans , myostatin and β-galactosidase increase with aging while follistatin , MyoD and myogenin decrease.
In humans , obesity has been associated with reduced testosterone production and subfertility.
In humans , presence of an A1 allele of the DRD2 / ANKK1-TaqIA polymorphism is related to reduced density of striatal DA D2 receptors.
In humans , rest promotes the consolidation of specific experiences , but the effect of rest on the wider integration of memories remained unknown.
In humans , seven sirtuin isoforms ( Sirt1 to Sirt7 ) have been identified.
In humans , telomerase mutations have been associated with familial diseases leading to bone marrow failure or lung fibrosis.
In humans , the developmental origins of interneurons in the third trimester of pregnancy and the timing of completion of interneuron neurogenesis have remained unknown.
In humans , the @number@ reported cases of Cr deficiency developed peripheral neuropathy , weight loss , and hyperglycemia.
In humans , the regulator of G-protein signaling-10 ( RGS10 ) locus has been associated with age-related maculopathy.
In humans , these findings have come almost solely from cross-sectional studies.
In humans , this sequence is TTAGGG , which is repeated over @number@ times.
In human teeth , odontoblasts are post-mitotic cells responsible for sensory function and dentin preservation.
In human trials , it improves both the signs and symptoms of moderate to severe dry eye with effects lasting beyond the treatment period.
In human tumors , down-regulation of E-cadherin is frequently associated with poor prognosis.
In human umbilical vein endothelium delphinidins concentration-dependently decrease intracellular oxygen radicals.
In human uveal melanoma however , a high density of macrophages is associated with a poor prognosis for the patient.
In Hutchinson-Gilford progeria syndrome ( HGPS ) , a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins.
In hypertensive participants significantly greater iron content was noted in all examined regions.
In hypertensive participants ( systolic blood pressure = SBP > or = 160 mmHg ) , the respective values were @percent@ and @percent@.
In hyponatremia with normal extracellular volume , there is free water retention due to a series of stimuli.
In hysterectomized women treated with estrogen only , a reduction in breast cancer risk was noted in all age groups.
In ignored repetition trials , the prime distractor was repeated as the probe target , whereas there was no stimulus repetition in control trials.
In iH-HIFKO mice , the biliary lipid concentration was reduced by @percent@ , compared with control mice , and bile flow was increased by @percent@.
In immature human brains , CREM multiple neuroblasts and radial glia cells expressed CREM.
In immunosuppressed individuals , CMV can reactivate and cause serious clinical complications , but the effect of the latent state on healthy people remains elusive.
In inactive lesions , the density of microglia / macrophages was significantly reduced and microglia in part converted to a P2RY12 + phenotype.
In individuals from these groups , brain lateral ventricular volume was positively associated with fat , energy and protein intake.
In individuals who are positive for amyloid-β pathology with symptomatic Alzheimer disease who usually have tau pathology , ε4-carriers demonstrate greater rates of disease progression.
In individuals with a sporadic primary tauopathy , the presence of an ε4 allele is associated with more severe regional neurodegeneration.
In individuals with obesity , differences in fat distribution and AT cellular composition may contribute to obesity related metabolic diseases.
In individuals without CKD , IR was associated with lower high-density lipoprotein and current nonsmoking status in multivariate analysis.
In individuals without T2D , fasting insulin correlated significantly with body mass index.
In industrialized countries , this is usually done with ultrasound ( phacoemulsification ) , followed by the implantation of an IOL.
In infancy and early childhood there is a measurable association between IS and preterm birth.
In interaction models with PM2.5 , both sICAM-1 and sVCAM-1 levels were lower in rs1062923 homozygous carriers.
In international age-adjusted comparisons , the HAALSI sample had lower physical performance outcomes than most comparison populations.
In interviews , all developers highlighted the importance , value and challenges of involving potential users.
In interviews in a variety of studies , participants talked of the importance of both inner and outer resources for empowerment.
In intrinsically aged buttock , epidermal HA and dermal tsGAG and tUA decreased.
In in vitro cell studies , silencing STXBP5 decreased the release of tPA from vascular endothelial cells , whereas silencing STX2 increased the tPA release.
In in vitro experiments , LPS-induced NF-κB and inflammatory-related cytokines were inhibited by betaine treatment in RAW @number@ murine macrophage cells.
In in vitro studies , P.g.
In in vitro studies , the combinations of fosfomycin with rifampicin and tigecycline were both synergistic.
In IPD population , some studies reported similar SWM and OWM deficits ; others reported a greater SWM than OWM impairment.
In Ireland , 83%-90% of cases are currently unexplained.
In ischemic mouse congestive heart failure model skeletal muscle wasting and attenuated muscle regeneration are Ang II dependent.
In isolated islets from these mice , glucose-stimulated insulin secretion was heavily impaired and exogenous GLP-1 or glucagon rescued insulin secretion.
In isolated renal proximal tubules , both NBC1 activity and the rate of bicarbonate absorption were markedly reduced.
In Israel , affectual solidarity was more strongly associated with amount of help.
In Italy , as in the rest of the world , several validation studies of MoCA have been carried out.
In Italy , by the year @number@ @percent@ of the population will be aged more than @number@ years.
In Italy , the last epidemiological estimation was reported well before the HTT gene discovery and the availability of the corresponding genetic test.
In Italy , there are different registers of dialysis and transplantation , providing an excellent means of monitoring patients in substitution treatment.
Initial assessment requires appropriate use and interpretation of imaging modalities such as x-rays and computed tomography.
Initial assistance to use the technologies , and the need for monitoring exertion , aggravation of musculoskeletal symptoms and falls risk were reported.
Initial BMI did not predict later outcomes.
Initial bypass patency was @percent@ in patients above the age of @number@ years and @percent@ in the younger group ( p = @number@ ) .
Initial conditionsmay in some cases determine the genetic composition and pattern of population size dynamics.
Initial covariates included age , gender , body mass index and all anatomic variables not directly related to the dissected segment.
Initial criterion validity was demonstrated by sensitivity to sex differences and the effects of age , education and parental education.
Initial endoscopic control offers an opportunity for selecting high-risk ulcers for potential early preemptive surgery.
Initial enrollment took place in childhood in @number@
Initial hemorrhage may be associated with a history of hypertension , AVM size and exclusively deep venous drainage.
Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly.
Initial images of cone beam computed tomography revealed a sequestrum at the extracted socket.
Initial impression of juiciness decreased with increased age of the animal and cooking losses increased nonlinearly with age , irrespective of the muscle.
Initial learning and memory retrieval were particularly vulnerable , whereas memory consolidation and storage were preserved.
Initial limited excisions gradually progressed to skin undermining and eventually to a variety of methods for contouring the subcutaneous facial tissue.
Initially and after aging , marginal qualities in enamel and dentin were evaluated using replicas at 200× magnification ( SEM ) .
Initially , DMF increased p21 protein stability through an enhancement in Nrf2 activity without an increase in p21 mRNA.
Initially , HNE-IR was present in few macular cone outer segments ( COS , sixth decade ) .
Initially , IFs were assumed to provide only structural reinforcement for the cell.
Initially performed in @number@ for eyelid reconstruction , blepharoplasty has evolved to become a cosmetic or functional operation.
Initially the aim of this article was to discuss and define aging at the intersection point between biology and sociology.
Initially , the cortical labels of each subject are partitioned into small patches ( graph nodes ) by spatial k-means clustering.
Initially , the presence of cross bridges was confirmed in cadaveric human discs aged @number@ and @number@ years.
Initially , there was a steep decline in the mirror-movement ratio during childhood and adolescence , followed by a gradual rise during adulthood.
Initially , we established NHE1-ko LS174 cells with inducible CA9 knockdown.
Initially , we illustrate well known modifications of cholinergic transmission during physiological ( normal aging ) and pathological neurodegeneration.
Initially , we profiled human primary tumor tissue epithelia and characterized about @number@ secreted and cell surface candidate glycoproteins.
Initial MoNNET-HA study participants ( n = @number@ ) were recruited for telephone interviews in the summer of @number@
Initial MRCP was the most cost-effective option with the highest monetary net benefit , and this result was not sensitive to model parameters.
Initial mRS score ≥2 , eloquent location and higher S-M grade may be associated with worsening functional status.
Initial neuroinflammation and / or accumulation of amyloid species followed by neurodegeneration , or congenital morphometric differences , may explain the observed features.
Initial poor function did not differ significantly between the groups ( @percent@ vs. @percent@ ; P = @number@ ) .
Initial print-based participants predominantly used print-based materials , whereas initial Web-based participants used both print- and Web-based materials.
Initial results from sequencing studies suggest that there are relatively few low-frequency ( < 5% ) variants associated with large effects on common phenotypes.
Initial results of both synergistic approaches indicate their potential to enhance broad cognitive abilities and prevent dementia.
Initial review of abstracts identified @number@ potentially eligible studies.
Initial search returned @number@ items with PubMed.
Initial soil Cu concentrations in Equus , SRB , and AGLR microcosms were @number@ @number@ and @number@ mg / kg dw , respectively.
Initial studies of the ovaries were based on postmortem anatomic descriptions , followed by histologic and endocrine approaches.
Initial studies using next generation sequencing are beginning to establish lower boundaries of T cell receptor diversity.
Initial swelling and bruising were seen as well as two cases of wound-healing disorders , but no surgical intervention or revision was needed.
Initial treatment with topical and oral corticosteroids was ineffective.
Initiating disease factors , as well as common mechanistic pathways , are detailed and potential immunological therapeutic targets are identified.
Initiating early breastfeeding within @number@ hour postpartum was the sole infant feeding practice positively associated with exclusive breastfeeding and WAZ.
Initiating prevention of additional conditions and treating disease constellations earlier to decrease BADL limitations may improve aging outcomes in this population.
Initiation of a prescribing cascade , whereby antimuscarinic agents or β3-agonists are added to treat symptoms of urinary urgency and incontinence , is best avoided.
Initiatives are warranted to address such disparities and promote greater diversity in NIH funding among diagnostic radiology investigators.
Initiatives by professional nursing organizations to improve the gerontological nursing workforce are also reviewed.
Initiatives to decrease the burden of stroke have largely focused on prevention and acute care strategies.
Initiatives to provide alternative care options on a user-pay model should be encouraged to ensure a sustainable health care system.
Initiatives with merit include those that encourage social interaction.
Initiators of joint pain are discussed in the context of clinical challenges including the diagnosis and treatment of pain.
In its absence , Müllerian ducts develop into female inner reproductive organs.
In its monomeric form , Aβ aggregates to produce fibrils and a range of oligomers , the latter being the most neurotoxic.
In its pioneering days , this association focused mostly on trauma / burn care and also influenced policymaking.
In its short history , anti-aging medicine has taken root as a medical practice that questions how to address biological aging.
In its simplest form , circadian clocks are composed of a set of proteins that generate self-sustained circadian oscillations.
In its simplest form , the LD regulates the storage and hydrolysis of neutral lipids , including triacylglycerol and / or cholesterol esters.
In Japan , cardiovascular diseases are frequent complications in cancer patients owing to the rapidly aging population and changes in the overall lifestyle.
In Japan , intramuscular injection of testosterone enanthate every @number@ to @number@ weeks is widely indicated for treatment of LOH.
In Japan , ' locomotion training ' consisting of one-leg standing and squatting exercise is recommended to prevent locomotive syndrome.
In Japan , LOH was treated not only with testosterone enanthate injections or testosterone ointment but also with Kampo medicine.
In Japan , @number@ million people are reported to have diabetes , and @percent@ of those are over the age of @number@
In Japan , number of elderly people with type @number@ diabetes mellitus are increasing.
In Japan , the elderly patients generally account for high percentages of both inpatients and outpatients.
In Japan , the number of elderly recipients who take medicines regularly has been increasing due to population aging.
In Japan , there are no detailed data regarding the incidence , biology , treatment , prognosis , and long-term outcomes of ML in AYA.
In Japan , where an aging society is to continue in the future , we need urgent countermeasure.
In Japan , which is becoming a super-aging society , the method of performing minimally invasive operations remains a major issue.
Injectable fillers may be combined with neurotoxins to resolve superficial wrinkles and restore facial volume.
Injectable fillers nowadays represent a pillar in facial rejuvenation and make a significant contribution to the success of the treatment.
Injectable poly-l-lactic acid-treated subjects maintained improvements for up to @number@ months after treatment.
Injectable poly-L-lactic acid-treated subjects were followed for @number@ months.
Injectable substances known as fillers are used to palliate age-related atrophy and ptosis , and for their so-called \ "pseudo-lifting \ " action.
Injected volume was aimed at achieving optimum correction ; top-up treatment was given at @number@ weeks if needed.
Injection into @number@ NLF was made via Artiste , and injection into the other NLF was made via manual delivery.
Injection of botulinum toxin type A ( BoNTA ) is the most common nonsurgical aesthetic procedure undertaken in the United States ( U.S. ) .
Injection of Cat316 into the perirhinal cortex normalized object recognition at @number@ hours in P301S mice.
Injection of mice with an SHP2 inhibitor blocked the production of germ cells from SSCs.
Injection-related adverse events occurred at similar frequencies with both products.
Injections are performed commonly with either needles or cannulas , but quantitative comparative data on precise implantation are still elusive.
Injections with BTX are the most effective nonoperative therapy for hyperhidrosis.
Injection with touch-up after @number@ month.
Injectors should be aware of this potential adverse event and counsel their patients appropriately.
Injured men and women were more likely to report arthritis , hypertension , ulcers , depression , and back problems than the comparator sample.
Injured women were also more likely to report migraine headaches and asthma.
Injuries among those with multiple recent falls were more likely to be head injuries with an open wound.
Injuries are a leading cause of hospitalization for children , young adults and seniors and a major cause of disability and death.
Injuries caused by accidental falls range from relatively innocent bruises to major fractures or head trauma.
Injuries caused by falls and injuries resulting in high-level tetraplegia and ventilator dependency are increasing , while neurologically complete injuries are decreasing.
Injuries were classified as \ "none \ " or minor in @percent@ , moderate in @percent@ , and major in @percent@.
Injuries were significantly more likely to be caused by a fall in elderly patients than in younger patients ( P < @number@ ) .
Injury and loss of glomerular podocytes are common determining factors of glomerular disease progression and renal failure.
Injury episodes began with the first index injury claim identified and ended when no further injury claims were found within @number@ days.
Injury , illness , and holidaying were the main reasons for ceasing participation.
Injury in Canada is a serious public health concern.
Injury incidence , discharge rates , healthcare costs , and quality of life measures were calculated.
Injury status ( preinjury , injury episode , postinjury ) was identified from Medicare claims and specified as a set of dummy variables.
In keeping with the hypothesis of reduced age-related NA influences , older adults showed attenuated induced PD responses to negative emotional events.
In keeping with the latter observation , we noted that compared to non-senescent keratinocytes , senescent cells lacked SIRT1.
In keeping with this , when using autophagy inhibitors or suppressing autophagy promoting genes , motor symptoms and motor neuron death are accelerated.
In KHQ , only the category of general health perceptions was significantly higher in depression patients than non-depression patients.
In kidney cortex , however , only one age-position was identified correlating with a late age-position.
In kl / kl mice , ACM reversed tissue calcification despite continued hyperphosphatemia.
In knockout mice , paralogues , such as BACE2 or cathepsin D , could partially compensate.
In Korea , the proportion of the pediatric population is decreasing due to low fertility rates and aging of the society.
In Korea , there is a means-tested and non-contributory public assistance , the National Basic Livelihood Security System ( NBLSS ) .
In landmark analysis , there was no regression to the mean after cessation of the NT-proBNP-guided strategy.
In LASA-II , no associations with BUA were observed.
In late adulthood in comparison to early adulthood there is the decline in openness to experiences.
In late modern circumstances , aging individuals are confronted with the task of creating a meaningful individual life trajectory.
In later childhood and adulthood the strength of this association reduces , and current body composition becomes the variable most strongly associated with IS.
In later life , optimistic health appraisals promote well-being and survival , whereas pessimistic appraisals can be harmful.
In later stages , the microglia and macrophages in active lesions changed to a phenotype that was intermediate between pro- and anti-inflammatory activation.
In Latin America , most cases occur in Brazil.
In Latvia , only limited research targeting the health and home situation of very old people is available.
In LA , we recruited English and Spanish speakers ; in SF the DCE was conducted in English only.
In layered osteoblasts , MSDK also decreased expression of the metabolic proteins PPARγ ( PPARG ) and GLUT4 ( SLC2A4 ) .
Inlays and onlays are often the minimal invasive solution in such cases , but the efficacy of the composite and ceramic materials used is unknown.
In LDL ( - / - ) mice , both apoA-I- and apoE-containing HDL looked normal.
In less developed countries , liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death.
In less frail men , however , effects of testosterone therapy in the ageing male are small and / or inconsistent.
In light of the age and sex differences in stroke outcomes , this review highlights how aging and gonadal hormones influence these responses.
In light of these ambiguities the present experiments were designed to answer the question in a more definitive fashion.
In light of these results , possible mechanisms that could reconcile the opposing findings on fibril continuity are discussed.
In light of these results , we recommend that measurement of bone mineral status should be part of the longitudinal clinical investigation of MFS children.
In light of this important role , the vascular endothelium is expected to have a self-defense system.
In linear discriminant analysis , the LVEF cutoff level that best predicted cognitive impairment was ≤51 %.
In linear regression analysis , age , gender and body mass index explained @percent@ of the variation in maximal walking speed.
In linear regression models , adipocytokines mediated associations among women.
In line , five days of disuse did not lower citrate synthase , β-HAD or cytochrome C oxidase activity in skeletal muscle tissue.
In line , skeletal muscle capillary contacts were much lower in the older and older type @number@ diabetic patients when compared with the young.
In line with a history of myofibre repair , a greater number of fibres with centrally located myonuclei were detected in O-Tr.
In line with a social expertise framework , middle-aged and older adults were more sensitive to trait-diagnostic behavioral information than were younger adults.
In line with muscle contraction , we also identified proteins related to calcium signal transduction ( calsequestrin-1 , sarcalumenin , myozenin-1 , annexins ) .
In line with previously published data , we observed higher proportions of Tregs in the elderly.
In line with previous resting state fMRI results , we showed distinct developmental effects on the strength of long-range frontoparietal versus frontoinsular short-range fixed connections.
In line with previous studies , we found improvements in measured stereoacuity in childhood and declines in late adulthood.
In line with theoretical models , we argue that this reflects an age-related bias towards pattern completion.
In line with these changes , high-resolution immunohistochemistry demonstrated decreased numbers of oligodendrocytes and of neuronal subpopulations in the aging brain cortex.
In line with these data , low PRL was associated with a lower level of physical activity and feeling unhealthier.
In line with this , it has been shown that the epigenetic machinery is essential for cognitive function.
In line with this , it is tempting to speculate whether HCV-dependent elevated ROS levels induce autophagy to support exosome-mediated release of viral particles.
In literature , an increasing number of papers indeed report on the bonding effectiveness of different luting techniques to zirconia.
In literature , many authors suggest that mortality rate in patients with FFP is similar to those with hip fracture.
In LOAD , HV provided the best discrimination power from age-matched controls.
In logistic regression analyses adjusted for site , pedunculated shape was statistically significantly associated with test sensitivity ( P = 0.04 ) .
In logistic regression analyses , unsuccessful scan outcome was predicted by prior MRI completion and ASI Mental Concerns subscale scores , but not clinical status.
In longitudinal analyses , persons with lower LINE-1 methylation were at higher risk for incident ischemic heart disease and stroke , and for total mortality.
In longitudinal analysis , negative trend was shown in the slope of tendency in total subjects.
In longitudinal case analysis , sleep and activity patterns were found to be associated with local weather variables.
In longitudinal mixed effects models , training and maternity leave were associated with lower 2-year aging-related cognitive decline.
In longitudinal observation studies we mainly observe inverse relations between fish intake or serum concentrations of DHA and cognitive impairment.
In longitudinal studies , physical frailty was found to predict the incidence of cognitive impairment and dementia.
In Long Life Family Study , heritability was determined with a variance component-based family analysis using a polygenic model.
In long-lived mammals , females that experience poor environmental conditions early in life may delay primiparity.
In looking to discover treatment , this review will endeavor to sight and state some central discrepancies between laboratory models and clinical scenarios.
In low- and middle-income countries , @number@ large observational studies have recently reported clinical characteristics and outcomes in these patients.
In lower eukaryotes , chronic fasting extends longevity , in part , by reprogramming metabolic and stress resistance pathways.
In low-resource settings , evidence of sleep problems and their potential association with mortality is lacking.
In LPS-stimulated monocytes , AF3442 caused a concentration-dependent reduction of PGE ( @number@ ) biosynthesis with an IC ( @number@ ) of @number@.41microM.
In LPS-stimulated whole blood , AF3442 inhibited in a concentration-dependent fashion inducible PGE ( @number@ ) biosynthesis with an IC ( @number@ ) of 29microM.
In LQT1 , after the age of @number@ years , male patients had a significantly shorter QTc interval than female patients.
In LQT2 male patients , this was preceded by a progressive QTc interval prolongation.
In LTC facilities where external educators were provided , a larger proportion of staff watched the videos.
In lung infiltrates not suggestive for IPA mycological confirmation is pursued.
In lymphoblastoid cell lines belonging to haplogroup B5a , we observed significantly increased reactive oxygen species and decreased mitochondrial mass.
In MA , increased retrieval activity in anterior PFC predicted increased retrieval accuracy.
In making this shift , government will harvest short-term gain that can only result in long-term pain for people in need of such services.
In Malaysia , the main causes of death in men are non-communicable diseases and injuries.
In male and female yaks , the prevalence was @percent@ and @percent@ , respectively.
In male patients , psychotic symptoms were associated with an increased number of leukocytes in blood.
In male rats , the incidences of focal suppurative inflammation were significantly increased in the @number@ and @number@ g / kg groups.
In males , a borderline statistically significant association with ADL level was found for UQCRFS1 gene.
In males , a negative association between intelligence and fast spindle density in posterior regions was found.
In males , however , isoflavones may protect the prostate to make them less prone to develop cancer.
In males , these prevalence values were @percent@ for grip strength and @percent@ for SPPB.
In mammalian cells , DNA-bound Fe ( II ) reacts with H₂O₂ producing the highly reactive hydroxyl radical ( OH ) in situ.
In mammalian cells , the nuclear lamina is composed of a complex fibrillar network associated with the inner membrane of the nuclear envelope.
In mammalian systems , however , hormonal contribution to longevity is less well understood.
In mammals and invertebrates , neurogenic genes harbor larger protein-coding regions and possess a richer regulatory repertoire of miRNA targets and transcription factor binding sites.
In mammals , caloric restriction consistently results in extended lifespan.
In mammals , however , PRCs are quiescent and exhibit very little activity and thus have low capacity for retinal regeneration.
In mammals , insulin-like growth factor-1 ( IGF-1 ) is positively correlated with adult body mass , in comparisons made within a given species.
In mammals , nearly all cells hold self-sustained circadian clocks meanwhile couple the intrinsic rhythms to systemic changes in a hierarchical manner.
In mammals , @number@ Sirtuin isoforms control various functions in metabolism , stress responses and aging processes.
In mammals seven sirtuin genes - SIRT1 to SIRT7 - have been identified.
In mammals seven sirtuin genes - SIRT1 to SIRT7 - have been identified.
In mammals , seven sirtuin homologs ( SIRT1-7 ) have been identified , with varied cellular locations and molecular functions.
In mammals , the obligate costs of reproduction are higher for females , making reproductive timing and rate especially liable to conflict between the sexes.
In mammals , there are seven homologs of the yeast Sir2 , Sirt1-7.
In mammals , thermoregulation is a key feature in the maintenance of homeostasis.
In mammals , the small Arf GTPase-activating protein ( SMAP ) subfamily of Arf GTPase-activating proteins consists of closely related members , SMAP1 and SMAP2.
In mammals , whether metabolic-sensing neurons govern aging in a cell-non-autonomous fashion is unknown.
In many cases , competitive interactions have been shown to guide such cell selection events.
In many cases , disparities were only evident or more pronounced among women.
In many cases , MCI represents an early stage of developing cognitive impairment.
In many cases , researchers are also interested in comparisons across species ( or conditions ) .
In many cases , the use of neuromodulators and fillers has replaced surgical procedures.
In many cases , this likely influences the quality of life and quality of care of residents.
In many cases , this parainflammatory response can maintain homeostasis in the healthy aging eye.
In many chronic diseases , the patient's health status is followed up by quantitative markers.
In many circumstances including CNS injury , there is a balance of inflammatory and intrinsic repair processes that influences functional recovery.
In many countries , they act as bridges between ambulatory / continuity of care systems and hospital-based intensive care and sophisticated therapies.
In many cultures , a youthful look is strictly linked to strong and healthy hair.
In many facilities , LOH treatment effectiveness was assessed after a 3-month period.
In many less developed countries , unfortunately , diagnosis of this disorder is delayed.
In many of these medication for Parkinson's disease was started.
In many others , it is considered only to contribute to the overall pathology.
In many regions , however , such knowledge is underutilized due to its often-fragmented record in disparate sources.
In many studies , resveratrol has been shown to have a chemopreventive effect in various types of cancer cells.
In many studies , the effects of placental size and shape on later disease have been examined within different categories of mother's body size.
In many tissues , including the brain , stem cells and progenitor cells undergo asymmetric cell division through the establishment of cell polarity.
In marked contrast is the lack of a better understanding of attempted suicide in the elderly.
In May-December births were below average.
In MCI and in a subset of normal aged persons , RL impairment may herald incipient dementia.
In MCI , increasing FSRP correlated with worse longitudinal delayed memory ( p = @number@ ) .
In MCI patients , recognition variability was best explained by the engagement of an additional network including BA @number@
In MCI , processing speed was negatively correlated with greater sleep time spent below @percent@ oxygen saturation and a higher apnoea-hypopnea index.
In MDS , mutations of genes such as NRAS and FLT3 , designated as Type-1 genes , may be significantly associated with leukemic evolution.
In medical studies , endpoints are often measured for each patient longitudinally.
In Melbourne , state political leadership established Positive Ageing plans that have reinforced local government actions.
In men , adult SES was inversely associated with adherence to the traditional-western food pattern.
In men aged 40-79 years the incidence of biochemical deficiency and symptomatic hypogonadism is @number@.1-5.7%.
In men aged over @number@ years , only MCW was significantly associated ( r = @number@ p < @number@ ) .
In men and postmenopausal women , there was no significant correlation between fat and bone parameters after adjusting for age and body weight.
In men and women , strength improves through neuromuscular adaptation , muscle fiber hypertrophy , and increased muscle oxidative capacity.
In men and women with the MetS , DBP remained nearly constant , but in those without the MetS , DBP increased.
In men , Asians and Caucasians had similar porosity and trabecular density.
In men , both forearm-radius and forearm-ulna MT were significantly correlated with TMM and TMM index.
In men , declining levels of testosterone ( T ) with age have been implicated in the development of these age-related changes.
In men , depressed mood and somatic symptoms were associated with larger WML volume at baseline.
In men , DQI-I scores were not associated with the number of body composition abnormalities.
In men , estrogens do not exhibit age-related reduction and are not significantly associated with AD risk.
In men , growth was not associated with the risk of pharmacotherapy for osteoporosis.
In men , hand-grip strength cut points for mobility increased with BMI , whereas in women , only one hand-grip strength threshold was identified.
In men , higher insulin levels are also associated with lower oxHDLlipid levels.
In men , highest levels of telomerase activity were found in the lowest education group.
In men , however , these relative values ( SMM index and SMM : FFM ratio ) were still higher in Germans.
In men , knee extension strength showed significant positive correlations with leg and appendicular muscle mass in both young-old and old-old age groups.
In men , lifespan is hypothesized to evolve from benefits of reproduction throughout adult life.
In men , lower cortisol predicts subsequent symptoms , independent of depressive history.
In men , midlife migrants had longer life expectancies and had more disability-free years than U.S.-born men.
In men , no physical function measure was consistently associated with quality of life in the fully-adjusted models.
In men , one SD increase in thigh muscle was associated with a decreased likelihood of dementia ( @number@ @number@.61-0.92 ) .
In menopausal conditions , however , estrogen deficiency allows HIF1α protein to accumulate in osteoclasts , leading to osteoclast activation and bone loss.
In men , oxHDLlipids were also associated inversely with insulin ( partial R ( @number@ ) = 1.1% ) .
In men , @percent@ violinists , @percent@ of conductors and @percent@ of cello-players survived 90 + years.
In men , perirenal fat volume and thickness showed a positive correlation with waist circumference and no correlation with subcutaneous fat thickness.
In men ReTm populations were small and random while in women they were large and sector-specific.
In men , several of the tested variables ( except muscle mass measures ) reported significant results.
In men , the association was found to be influenced by cardiovascular risk factors.
In men , the risk of hip fractures was nonlinearly associated with childhood growth.
In men , the strength of this association was @number@ to @number@ times stronger with the accelerometer than with questionnaire data.
In men , this association may partly be explained by calcifications of the abdominal aorta.
In men , VAT was related to MetS only among the overweight ( OR = @number@ P < @number@ ) .
In men with prostate cancer , the BPAQ was not an independent predictor of BMD.
In men with prostate cancer , the BPAQ was not significantly associated with BMD.
In men , wrinkles manifested earlier and were more severe than in women.
In mesenchymal stromal cells ( MSC ) from human bone marrow we have previously demonstrated age-associated methylation changes at specific CpG-sites of developmental genes.
In metazoa , adhesion receptors of the classical cadherin family play important roles in establishing and maintaining such tissue organization.
In Mexico glucose intolerance is present in 15-20% of the population older than @number@ years and increases the risk for developing diabetes and cardiovascular disease.
In mice , ablation of CAP2 leads to development of cardiomyopathy.
In mice and humans , a decrease in urinary excretion of fibrillar collagens and an increase of uromodulin fragments was observed with advanced age.
In mice , deficiency for the Sir2 family member SIRT6 leads to genomic instability , metabolic defects and degenerative pathologies associated with aging.
In mice , IGF-1 deficiency is associated with dwarfism , whereas IGF-1 overproduction in transgenic animals causes gigantism.
In mice older than @number@ months , induction of Ezh2 was unable to repress Ink4a.
In mice , Osbpl2 was prominently expressed in stereocilia of cochlear outer and inner hair cells.
In mice repeatedly treated with UVB , the epidermis became hyperplasic and keratinocytes lacked HIF-1alpha in nuclei.
In mice , Smchd1 regulates chromatin repression at different loci , having a role in CpG methylation establishment and / or maintenance.
In mice , the ability to regenerate HCs from surrounding supporting cells ( SCs ) declines abruptly after postnatal maturation.
In mice , the overexpression of the KL gene extends the life span , whereas mutations to the KL gene shorten the life span.
In mice , this mechanism mediated adaptation to food availability after starvation and physical exercise and played an important role in cancer growth.
In microvascular endothelial cells exposed to ACEI , Akt / eNOS pathway-dependent FGF-2 was necessary for gene transcription of TERT.
In middle-aged and elderly Asian populations , depression can lead to weight loss rather than obesity , and underweight may develop depressive symptoms.
In middle-aged , but not in elderly , women the presence of early pre-arousal low delta power was associated with shorter arousals.
In middle-aged lenses , the absorption at 360nm is mostly provided by UV filters contained in the MET fraction.
In middle-aged men , metabolic syndrome had a significant negative association with OAB rate.
In middle-aged participants , no SWB indicator predicted mortality when controlling for covariates.
In middle age Native Americans ( SHS ) , H1 carriers showed higher fasting insulin and HOMA in males , and higher BMI in females.
In-migrants swelled urban cohorts of reproductive age and delayed the urban fertility transition.
In military operations , declined physical capacity can endanger the life of soldiers.
In mitochondrial disorders , short stature is a common symptom , but its underlying lesion , growth hormone deficiency , is rarely investigated.
In MLR and PCA , CA is treated as the selection criterion and an independent index.
In MMD and CAD , cortical and central CBF decreased significantly with age , whereas CVRC and hemodynamic stress distribution are relatively unaffected by age.
In MoCA the cutoff score between healthy and MCI persons was @number@ out of @number@
In Model @number@ subjects with all four domain scores above the 50th percentile were classified as \ "successful agers. \ "
In model organisms , over @number@ genes have been shown to modulate aging , the collection of which we call the ' gerontome'.
In model organisms such interventions must also increase lifespan to be considered significant , but this is not a requirement for use in humans.
In models that control for patient characteristics , we observe statistically significant declines in 1-year hip fracture readmission and mortality rates.
In model systems , decorin binds to and protects type I collagen fibrils from proteolytic degradation by enzymes such as MMP-1.
In moderately or severely degenerated segments , the ICR location change reached statistical significance ( P < @number@ ) .
In modern societies , the proportion of women who delay childbearing beyond the age of @number@ years has greatly increased in recent decades.
In modern society , aging and chronic disease is becoming common phenomenon due to the increasing numbers of elderly patients.
In modern studies , researchers have explored the accuracy of bone age across various ethnicities in the United States.
In modern times it is therefore often used to treat diabetes , pre-diabetes , fatigue and people with metabolic syndrome.
In monkey , neural oscillations are involved in either intrahemispheric or interhemispheric integrative brain function.
In monocyte TNF-alpha-stimulated there is a down-regulation of the phosphatase SHP-1 which induces a significant activation of TAK-1 / IKK / NF-kB signaling.
In monopolar configurations , RF will penetrate deeply and return via a grounding electrode.
In more complex disorders , where aetiology remains controversial , interactions with the clockwork are only now starting to be appreciated.
In more detail , there were regional differences between both arterial spin-labeling sequences.
In more problematic cases children benefit from a sleep programme.
In more progressed osteoarthritis , the final ability was lower , but the improvement gained was greater.
In more severe cases , a dermofat graft harvested from the intergluteal crease was used.
In Moscow men and women , the delayed variant of development of age involution changes is the most widespread.
In most animal species female germ cells are the source of mitochondrial genome for the whole body of individuals.
In most cases , 10-week intervals appear to be sufficient.
In most cases , a surgical approach with subsequent rehabilitative treatment is required.
In most cases , debonding occurred at the adhesive / bracket interface or within the adhesive.
In most cases metal extractability increased with decreasing size of particles , in particular , lead exchangeability was highest for channeled emissions.
In most cases , MRI showed a mixed pattern of increased / decreased T1 signal ( fine trabecular or coarse ) of the vertebral bodies.
In most cases , promising results were found for immersive technologies to challenge age-related declines , especially through the increase of morale.
In most cases the clinical examination can identify the type of pathology.
In most cases , the kinematic features of children are closer to those of adult men than adult women.
In most cases , the patient can be discharged within @number@ to @number@ days after the PPCI , provided that careful triage is applied.
In most cases , there is overwhelming evidence that impaired mitochondrial function is a causative factor in these diseases.
In most cases , they are simultaneously present in the same individual and commonly lead to bone fracture or cardiovascular disease ( CVD ) .
In most cases , topical cooling and numbing using icepacks is sufficient , even in an apprehensive patient.
In most cases , young women are affected , and an association of AWP with cystic fibrosis ( CF ) has been surmised.
In most cells , NF-kappaB function is induced upon activation of cells by various stimuli.
In most countries , clarithromycin and metronidazole resistance rates are markedly high.
In most countries HIV prevalence in adults aged @number@ years and above is higher than in the total population.
In most experiments , older adults benefitted more from positive than negative feedback , but only with large feedback magnitudes.
In most modern societies , the relationship that many individuals have with food has fundamentally changed from previous generations.
In most of the elderly people prevail an insufficient intake of one or more micronutruients.
In most organisms , genome haploidization requires reciprocal DNA exchanges ( crossovers ) between replicated parental homologs to form bivalent chromosomes.
In most other countries , rates are far lower.
In most patients receiving PN at home or after surgery , 60-100 mcg / day will meet their requirements.
In most people of our cohort , hip fracture was caused by a fall that occurred on the side during the morning.
In most tissues , there is an age-related decline in stem cell functionality but not a depletion of stem cells.
In mouse brain , ablation of α-synuclein function significantly suppresses Tau phosphorylation at Ser ( @number@ ) .
In mouse ESCs , p53 can also be functionally activated , but the precise biological consequences are not well characterized.
In mouse HSCs , Pot1a knockdown increases DNA damage response ( DDR ) and inhibits self-renewal.
In mouse islets , we show that DJ-1 prevents an increase in reactive oxygen species levels as the mice age.
In mouse models , TRX80 was associated with a proinflammatory status and increased atherosclerosis.
In mouse oocytes , cohesin becomes depleted from chromosomes during female aging.
In mouse skin , we found that adiponectin was present and decreased markedly with aging.
In MPN patients , CXCL10 is highly expressed in JAK2V617F but not JAK2WT MPN or healthy donor controls.
In MSCs from elderly donors , however , osteoblastogenesis was greatly diminished in an inflammatory environment whereas adipogenic differentiation remained unchanged.
In multicellular organisms , mTOR regulates cell growth and metabolism in response to nutrients , growth factors and cellular energy conditions.
In multicellular organisms , the PN is regulated at the cellular , tissue , and systemic level to ensure organismal health and longevity.
In multicellular organisms the proper system functionality is ensured by the balance between cell division , differentiation , senescence and death.
In multilinear regression analysis , apnea-hypopnea index was independently associated with IR after adjustment for several confounding factors.
In multinomial logistic regression analysis , increasing age , less education status , lower Barthel Index score and depression were positively associated with physical frailty.
In multiple linear regression , only age predicted total IGF1 , whereas age and IGFBP1 predicted bioactive IGF1.
In multiple regression analyses of the relative predictive ability of each approach , only the psychological approach ( perceived self-efficacy and optimism ) retained significance.
In multiple regression analyses , severity but not rotavirus infection had significant negative impacts on the utility of both the children and their caregivers.
In multiple regression modeling examining predictors of SPSA in each group , there was a tendency toward lower associations in the O-O group overall.
In multiple regression models the presence of baseline MetS was not associated with cognitive decline over time ( p > @number@ ) .
In multiple studies DNA methylation has proven to be an accurate biomarker of age.
In multivariable-adjusted Cox analysis , ESR1 rs2234693 and rs9340799 were not significantly associated with the risk of decline on any of the cognitive tasks.
In multivariable-adjusted generalized linear mixed models , baseline DM diagnosis was associated with decline on immediate and delayed word recall and the Clock Drawing Test.
In multivariable-adjusted models , higher SDF-1 levels were associated with lower total hip BMD ( p = @number@ ) .
In multivariable analyses , glycaemic status was not independently associated with four-frequency or high-frequency average hearing loss.
In multivariable analyses , inadequate health literacy was associated with worse physical health and more depressive symptoms.
In multivariable analyses , older age and less education independently predicted worsening YEM and distensibility coefficient.
In multivariable analyses , there were no significant associations between examined dietary exposures and AF risk.
In multivariable analysis , prefrailty / frailty was independently associated with a higher VACS Index score ( odds ratio @number@ p = 0.019 ) .
In multivariable analysis , the association between alcohol use and VACS index trajectory membership remained significant ( P = @number@ ) .
In multivariable Cox models only diagnosis ( myeloid disease ) impaired OS and PFS.
In multivariable logistic regression analysis , psychological or sedative drug use predicted recurrent falls , ED revisits , subsequent hospitalizations , and adverse events.
In multivariable models , an abnormal 18F-florbetapir scan by expert rating was not associated with a diagnosis of mild cognitive impairment.
In multivariable models , attitude toward life was not an independent predictor.
In multivariable models , emotional support was associated with emotional well-being ( b = @number@ @percent@ CI : @number@ @number@ ) .
In multivariable models , no change was observed in the number of potentially interacting prescriptions.
In multivariable regression analyses , high age ( β = @number@ 95%CI = @number@ to @number@ p = @number@ ) predicted decrease in cognitive performance.
In multivariate analyses , a history of incarceration was associated with a higher VACS Index score ( β @number@ @percent@ CI @number@.52-4.43 ) .
In multivariate analyses , different domains of cognitive functioning predicted distinct facets of driver safety on road.
In multivariate analyses , menopausal status remained statistically significant only for grip strength.
In multivariate analyses , the following elements remained associated with frailty : timed walk , pulse pressure , cognition deficits and hearing deficits.
In multivariate analyses , the significant association could not be reproduced ( p > @number@ ) .
In multivariate analyses , the two BMI measures similarly predicted disease prevalence across a number of chronic conditions.
In multivariate analysis , 48-hour MMP-2 levels were independently associated with WMHv ( β = .12 , P = .04 ) .
In multivariate analysis , adjusting for demographic characteristics , previous diagnosis of depression was negatively associated with resilience.
In multivariate analysis , a higher level of education and the area of work were associated with better test scores.
In multivariate analysis , BLM mRNA and BLM protein levels independently influenced BCSS.
In multivariate analysis , Grids and Distance were mainly affected by age.
In multivariate analysis , Lp ( a ) cholesterol was not significantly associated with CHD risk in men.
In multivariate analysis , only hip abductor strength predicted both TUG and WS ( both P = @number@ ) .
In multivariate analysis , preoperative albumin , hip surgery , and APACHE II score were independent predictors of HR.
In multivariate analysis , the associated pituitary deficits seemed stronger determinant factors of metabolic and bone status than GHD.
In multivariate Cox regression analysis , both high-risk category and mean stent ( s ) length were identified as independent predictors of MACCE.
In multivariate logistic regression analyses , relations between asthma and rhinitis were significant.
In multivariate logistic regression analyses , smoking , asthma and allergic rhinitis were found to be risk factors for cough in the elderly.
In multivariate logistic regression models , MCP-1 and TNF-α remained significant after adjustment for traditional cardiovascular ( CVD ) risk factors.
In multivariate models , common genetic factors were observed for global and lobar total and gray matter volumes.
In multivariate models , higher age , impaired cognition , and lower grip strength were independently associated with nonadoption.
In multivariate models , only FA has an age-independent effect on IIV.
In multivariate regression analyses , SUA resulted to be significantly associated to hypertension and metabolic syndrome prevalence , and IMT.
In muscle and liver , accumulation of lipids impairs insulin signaling.
In muscle cells and HEK293 cells , downregulation of SIRT1 reduced , while overexpression increased , insulin-induced PKB activatory phosphorylation.
In muscle there are significant differences between Hba levels in old and young mitochondria.
In mutant mated females , reproduction was decreased compared to controls , indicating a lack of tradeoff between this trait and lifespan.
In mutant unmated females , increased lifespan was associated with elevated locomotion at older ages , indicating slowed aging.
In myosin heavy chain IIA fibers , single-fiber isometric tension and molecular level mechanical and kinetic indexes were correlated with whole muscle isokinetic power output.
Innate and adaptive immune function was assessed by ex vivo whole blood stimulation with lipopolysaccharide ( LPS ) and phytohemagglutinin , respectively.
Innate IgM memory B cells , the largest pool in infants , are generated in the spleen by a germinal center-independent mechanism.
Innate immune system cells such as dendritic cells ( DCs ) from the elderly display a pro-inflammatory phenotype associated with increased reactivity to self.
In National Social life Health and Aging Project Wave @number@ the MoCA-SA had good internal reliability ( Cronbach α = 0.76 ) .
In nearly every major disaster , elderly populations have suffered disproportionate morbidity and mortality.
In neonates , @percent@ of the blocks reached a cranial level of ≥Th12 vs @percent@ and @percent@ in infants and toddlers , respectively.
Inner ear OPG may enter the bony otic capsule through the lacuno-canalicular porosity ( LCP ) .
In neural development , LCPUFA deficiency can lead to severe disorders like schizophrenia and attention deficit hyperactivity disorder.
In neural systems , information processing can be facilitated by adding an optimal level of white noise.
In neurodegenerative diseases activation of immune cells is thought to play a major role.
In neurodegenerative diseases , where aberrant neuronal death is an outstanding feature , there is an increase in caspase activity.
In NF-κB reporter mice , topical HOCl reduced LPS-induced NF-κB signaling in skin.
In NHAP but not CAP , the proportion of highly severe pneumonia ( CURB-65 score ≥ @number@ ) was lower in older patients.
In nine studies , shift and day workers were compared and interactions with age were addressed.
In Nissl-stained histologic sections , the PPN extended for more than @number@ mm in the rostro-caudal axis being closely attached to the lateral parabrachial nucleus.
in noise ( SRTn ) scores were calculated , corresponding to @percent@ speech intelligibility.
In nonagenarians , the quality of cf-DNA appeared similar in the original and follow-up samples.
In nondemented controls , lower hippocampal volume was associated with decreased gray / white matter tissue contrast globally across the cortical mantle.
In nondemented participants , there was a trend for lower baseline fitness to be related to cognitive decline.
In nondiabetics , grading of DDF by E-E'norm correlated with grading by filling pressure E / E'.
In none of the good quality studies was evidence found for savings in health care expenditures or reduction in hospitalization recourse.
In non-Hodgkin lymphoma , the common malignancies affecting AYA include diffuse large B-cell lymphoma , Burkitt lymphoma , and anaplastic large cell lymphoma.
In non-Hodgkin's lymphoma , attempts have been made to determine the treatment method by stratifying the risk using the results of GA.
In non-human and human primates , CR with adequate nutrition protects against abdominal obesity , diabetes , hypertension and cardiovascular diseases.
In nonhuman primates , a 2-year high-fat , high-sucrose diet increased hepatic mIndy expression.
In non-involved dermis , Gal-3 was detected strongly in the epidermis and in the vasculature.
In non-loaded aged bones , down-regulated genes are enriched for MAPK , Wnt and cell cycle components , including E2F1.
In non-NM cells , the α-synuclein expression profile was similar across age groups.
In nonobese participants , changes in weight had no effect on changes in multimorbidity over time.
In non-O group , the vWF plasma level in A1381T gene polymorphism with AG mutant is significantly higher than that with AA mutant.
In nonphotosynthetic eukaryotic cells , mitochondria are well-investigated major sites of ROS generation and related signal initiation.
In nonviral preclinical models , the angiogenic cytokine VEGF-A has been identified as a critical regulator of NMSC.
In normal ageing , there is increasing MTA score.
In normal aging , greater muscle co-activation is induced during gait in elderly adults.
In normal aging , people are often able to self-regulate driving behavior with respect to their medical conditions.
In normal aging , the effect of LCPUFA on prevention of cognitive impairment will be discussed.
In normal cells , telomeres shorten each time a cell divides ultimately resulting in cell senescence.
In normal healthy Japanese people who ate normally and lived an independent life , there are significant age- and gender-related differences.
In normal rats , the infusion of rat recombinant FGF23 enhanced phosphaturia and increased renal FGFR1 expression ; however , Klotho expression was reduced.
In normal RPE cells arrested by serum withdrawal , the mTOR / pS6 pathway was inhibited and cells remained quiescent.
In normal subjects , the retinal layers ' optical intensities were affected by image quality.
INNOVATION : 6BIO exerts the unique property of increasing stress tolerance and in parallel partially suppressing the nutrient-sensing pathway signaling.
INNOVATION AND CONCLUSION : H2S targets the Cys320 / Cys529 motif in Kv4.2 to regulate the Ito potassium channels.
Innovation and Conclusion : miR-200c disrupts SIRT1 / FOXO1 / eNOS regulatory loop.
INNOVATION : Currently , no molecular mechanisms linked to metabolic ARHL have been identified.
INNOVATION : Here , we describe the challenges discussed and offer clinical recommendations for practices who are working to meet them.
Innovative measures and exercise programs may need to be developed before efficacious screening and treatment strategies can be used in clinical settings.
Innovative models of care are emerging to improve quality of care and enhance cost savings for the geriatric patient.
Innovative use of bioactive ceramics with genetic control of in situ tissue responses offers the potential to achieve both tissue regeneration and prevention.
In NSCLC patients , high expression of LINC00858 closely correlated with tumor progression.
In NT , intravascular superoxide emerged in the oldest subgroup , whereas it appeared earlier among HT.
In NT , tempol enhanced endothelial function in the oldest subgroup ; in HT , the potentiating effect started earlier.
In nude mice , HFS pretreatment restored the osteogenic ability of senescent hAMSC.
In @number@.3-52.9 % of patients with AD dementia , a typical CSF profile for AD was detected.
In @number@ acute rejection biopsies , glomerulitis was present in @number@ cases ( group G ) and absent in @number@ ( group G0 ) .
In @number@ adults , aged 38-87 years , CSF klotho measurements were made at baseline and every 6h up to 18-30 h later.
In @number@ age stereotypes switched from being positive to being negative.
In @number@ Alois Alzheimer first characterized the disease that bears his name.
In @number@ an Australian collaboration ( Ozcandrive ) joined the project funded by an Australian Research Council ( ARC ) Linkage Grant.
In @number@ and during few years , elderly people produced their own work of creation.
In @number@ and @number@ patients , a paired histology and LS were available at the end of LAM-ADV treatment , respectively.
In @number@ an estimated @number@ ED visits , @number@ hospitalizations , and @number@ deaths listed AF as primary.
In @number@ a new recessive cohesinopathy disorder , designated Warsaw breakage syndrome ( WABS ) , was described.
In @number@ approximately @number@ million US adults reported sleeping ≤ @number@ h.
In @number@ approximately @number@ million women were receiving hormone replacement therapy ( HRT ) for alleviation of menopausal symptoms.
In @number@ approximately one in five of all HIV-infected Americans was among the @number@ million who left a correctional facility that year.
In @number@ a random sample of @number@ men were clinically investigated , @number@ of them with AHA.
In @number@ aspirin-treated patients , serum thromboxane B ( @number@ ) levels were also measured.
In @number@ a study was conducted to evaluate how PACE operates under for-profit versus nonprofit status.
In @number@ a third follow-up of this population was performed to assess cardiovascular risk and mortality rate between @number@ and @number@
In @number@ cases , primary fascial closure was achieved ; in @number@ cases , PADM was used as a bridge.
In @number@ cases , the drug dose far exceeded the @number@ mg necessary to produce an antipsychotic effect.
In @number@ Charles Winick proposed that addiction was a self-limiting process , whereby individuals stopped using substances once the stresses of life transitions ceased.
In @number@ clinically normal individuals , the relationship was comparatively linear.
In @number@ C. Miller Fisher described late-life migraine accompaniments as transient neurological episodes in older individuals that mimic transient ischemic attacks.
In @number@ cognitive performance in 19-y-old male conscripts was reported not to have been affected by exposure to the famine before birth.
In @number@ cognitive testing was performed in @number@ participants aged @number@ to @number@ years.
In @number@ Dr Yanagisawa's group identified endothelin-1 ( ET-1 ) as the first endothelium-derived contracting factor.
In @number@ experiments , the authors examined whether a single act of testimony can inform children's subsequent information seeking.
In @number@ experiments , we evaluated this possibility by having young and older adults study negative , positive , and neutral words.
In @number@ families , autosomal dominant pattern of inheritance was present in @percent@ of cases.
In @number@ first described the diagnostic criteria.
In @number@ Fonseca and San Miguel ( Prognostic factors and staging in multiple myeloma.
In @number@ fresh male and female cadavers , three full-thickness lip resections were investigated in a blinded fashion for specific histologic features.
In @number@ HFPG accounted for @percent@ ( @percent@ UI : @number@.4-5.3 ) of DALYs from all causes.
In @number@ higher age and comorbidities was associated with VMFO-use.
In @number@ higher education was associated with VMFO-use while age and comorbidities was not.
In @number@ h testing , only Deflex was more toxic according to the Control group ( p < @number@ ) .
In @number@ in Quebec City , three professional painters have created a none lucrative organization called Les Pinceaux d'Or ( The Golden Brushes ) .
In @number@ it classifies children under developmental risk degrees.
In @number@ it was estimated that @number@ % of the adult population ( @number@ million ) have diabetes.
In @number@ Laura lost her voice and was diagnosed with spasmodic dysphonia.
In @number@ lifetime risk of THR was as high as @number@ in @number@ women in Norway , and @number@ in @number@ men in Finland.
In @number@ long-livers a quantity CD4 + and CD8 + corresponded to standard , @number@ of them demonstrated actT exceeded standard.
In @number@ MCs were better embedded with other regional care and were delivering services for dementia with less emphasis on university-based research.
In @number@ Medicare beneficiaries began receiving prescription coverage benefits through Part D of the Medicare benefit.
In @number@ men with multiple peripheral fractures , trabecular spacing and distribution remained increased after adjustment for aBMD.
In @number@ mo hearts , in vivo angiogenesis was functional , sustained and comparable to neovascularization observed in @number@ mo hearts.
In @number@ monozygotic twins , we investigated the association of DNAmAge , difference between DNAmAge and chronological age and age acceleration with cognition.
In @number@ months after colostomy , the indicators estimating physical well-being were above in the control group , the indicators estimating mental well-being were comparable.
In @number@ months , we collected @number@ brains.
In @number@ mother-neonate pairs , we evaluated the associations between DNAm GA and a number of maternal and offspring characteristics.
In @number@ M. Raymond described a progressive muscle wasting and weakness in @number@ individuals survivors of childhood acute poliomyelitis.
In @number@ news from research has clearly shown that dermatology is bound to occupy a more important place in fundamental research.
In @number@ @number@ new cancer cases and @number@ cancer deaths occurred in Korea.
In @number@ @number@ of them repeated these assessments with additional determination of Barthel index , Mini Mental State Examination and Geriatric Depression Score.
In @number@ @number@ of the original runners participated : three passed away between @number@ and @number@ and one declined to participate.
In @number@ @number@ of these were located and re-interviewed.
In @number@ @number@ patients died ; @number@ were excluded ( stillborn infants ) .
In @number@ @number@ ( @percent@ ) individuals aged 65-79 years were re-examined ( average follow-up @number@ years ) .
In @number@ @number@ women aged @number@ to @number@ years in the NHS and @number@ men aged @number@ to @number@ years in the HPFS were included.
In @number@ observers , a comparison was made between this and values obtained with the centre and periphery method.
In @number@ of @number@ general aviation accidents , @percent@ were fatal compared with @number@ of @number@ airline mishaps in the United States.
In @number@ of @number@ patients ( @percent@ ) , @number@ mutations and @number@ novel variants of unknown significance ( VUS ) were identified.
In @number@ of @number@ patients ( @percent@ ) , the serum lactate level after exercise was elevated.
In @number@ of @number@ sibships with a histologic or ultrasonographic diagnosis of nephronophthisis-related ciliopathy , we detect the causative gene.
In @number@ of these subjects , dark adapted visual threshold was also measured.
In @number@ participants , follow-up occurred at @number@ years and @number@ years.
In @number@ participants , HbA1c was available at these two times.
In @number@ participants , postprandial triglycerides and apoB48 levels were measured.
In @number@ participants who returned for follow-up , 5-year changes in depressive symptoms and exercise capacity were associated with 5-year changes in functional status.
In @number@ patients , affected by Parkinson disease or Lewy body dementia , the crisis was categorized as AC.
In @number@ patients , anti-tumor necrosis factor ( TNF ) therapy was initiated , and the CD56 + monocyte frequency was monitored longitudinally.
In @number@ patients , concomitant allergies to D. pteronyssinus and Alternaria were observed.
In @number@ patients , erythema lasted longer than @number@ weeks.
In @number@ patients follow-up data were obtained after @number@ ± @number@ years.
In @number@ patients ( @percent@ ) AEs were recorded.
In @number@ patients ( @percent@ ) we found previously unrecognized COPD.
In @number@ patients , RBCLS was measured once , while in @number@ patients , up to @number@ repeated RBCLS measurements were available.
In @number@ patients , the definitive diagnosis remained unclear because the patients did not undergo surgery or follow-up colonoscopy after nonoperative treatment.
In @number@ patients , we assessed glucose kinetics with an infusion of @number@ , 6- [ 2H2 ] glucose.
In @number@ patients with heart failure , plasma concentrations of miR-126 were up-regulated with improvement of the NYHA class from IV to III.
In @number@ patients with @number@ , XX karyotype we performed interphase FISH using X alpha-satellite probe in order to identify X chromosome mosaicism rate.
In @number@ patients with Q max less than @number@ ml / s bipolar TURP was the treatment.
In @number@ patients with Q max more than @number@ ml / s alfa blockers were introduced.
In @number@ patients with Q max more than @number@ ml / s treatment was watchfull waiting.
In @number@ PCa and @number@ controls , C-reactive protein ( hs-CRP ) , adiponectin and insulin were determined.
In @number@ people aged more than @number@ years old accounted for @percent@ of Japan's entire population.
In @number@ @percent@ of all IEP candidates who completed the UBC program passed the written component , and @percent@ passed the clinical component.
In @number@ @percent@ of the population in Asia were aged @number@ years and over.
In @number@ @percent@ of the total population in Japan was @number@ years old and over.
In @number@ persons with microbleeds , we labeled microbleeds on baseline and follow-up magnetic resonance images.
In @number@ she found her voice again.
In @number@ states , at least one party , Republican or Democrat , hosted a state party platform process.
In @number@ studies , we investigated age effects in the ability to recognize dynamic posed and spontaneous smiles.
In @number@ studies with independent samples , we tested the idea that older adults ' performance will be enhanced in multimodal emotion recognition tasks.
In @number@ subjects , a comprehensive medical examination including a structural @number@.0-tesla magnetic resonance imaging scan was administered , as well as extensive neuropsychological tests.
In @number@ × Tg-AD mice , training decreased the neuropathologies with transient amelioration of memory decline.
In @number@ the ability to perform activities of daily living was assessed among @number@ respondents ( @percent@ of the survivors ) .
In @number@ the American Association of Colleges of Nursing ( AACN ) adopted a position statement concerning the future of advanced practice nursing education.
In @number@ the authors traced as many of these participants as possible and invited them to take part in a follow-up study.
In @number@ the average number of drinks per day for HRS women in the increasing drinker and consistent drinker trajectories was @number@ and @number@ respectively.
In @number@ the cost of hospitalization for each stroke was estimated at €3 , 047.
In @number@ the FDA publicized a set of new requirements for marketing over-the-counter sunscreens in the United States.
In @number@ the first cases of atypical femoral fractures ( AFF ) , occurring in the shaft of the femur , were reported.
In @number@ the government built emergency medical service centers ( the ICU-type model ) and reorganized all emergency medical facilities into three levels.
In @number@ the HSE @number@ focussed on older people.
In @number@ the majority of residential care communities had 4 25 beds , yet @percent@ of residents lived in communities with more than @number@ beds.
In @number@ the mean age was @number@
In @number@ the number of incident dialysis patients in this group was projected to increase by @percent@ in men and @percent@ in women.
In @number@ the number of NEXus schools reached @number@ with @number@ schools offering both doctor of philosophy and doctor of nursing practice courses.
In @number@ the OOSR is likely to be closer to @number@ to @number@ !
In @number@ the percentage of first-time donors ranged from @percent@ to @percent@.
In @number@ there were about @number@ @number@ @number@ new cancer cases and @number@ @number@ @number@ cancer deaths in China.
In @number@ there will be more than @number@ million older Americans.
In @number@ these values for NLS women were @number@ and @number@ respectively.
In @number@ the world health organization published the first global recommendation for physical activity and health.
In @number@ those surveyed had a mean age of @number@
In @number@ we conducted a case study aiming to describe the characteristics of the patients and the reasons for consultation.
In @number@ we identified LMNA mutations among a subset of AWS cases using a candidate gene approach.
In @number@ years , @number@ participants ( 13·9 % ) developed undernutrition.
In @number@ years of Spalax research , spontaneous tumors have never been recorded among thousands of individuals.
In nursing homes PEM prevalence of mild hyponatremia was @percent@ ( 95%CI @date@ @number@ ) .
In nursing , there should be more focus on developing knowledge of inner health resources , including positive life orientation and meaningfulness in life.
In OA cartilage , chondrocyte clusters showed strong FOXO phosphorylation and cytoplasmic localization.
In OA , changes in chondrocytes lead to the autolytic destruction of cartilage.
In obese animals , reduced APPL1 expression contributes to both insulin resistance and defective insulin secretion.
In obesity , chronic inflammation is derived from energy surplus that induces adipose tissue expansion and adipose tissue hypoxia.
In OCT images , some changes were evident at the transparent dentin in attrited teeth.
In OK cells , dopamine decreases NHERF-1 association with NKA α1 but increases its association with D1R.
In old age , 5-10% percent of all falls result in a fracture , and up to @percent@ of all fractures result from a fall.
In old age , B cell development may progressively be diverted into a preBCR-compromised pathway.
In old age , both sets of mechanisms decline , reflecting senescent change in both networks.
In old age , osteoporosis is associated with a substantial burden in terms of morbidity and mortality.
In old age , quality of life depends mainly on avoidance and management of age-associated diseases rather than chronological parameters.
In old age , the capacity to generate an unopposed proinflammatory innate immune response is predictive of long-term survival.
In older ( 8-9-month-old ) O-GlcNAcase transgenic mice glucose tolerance is no longer impaired.
In older adults , age , lower limb strength , and joint flexibility explained up to @percent@ of the variance in functional measures.
In older adults , an effect of the nature of the categorical relations to be used was revealed.
In older adults , BMI and PA influenced HRQL.
In older adults , chronic CMV infection is conventionally diagnosed by positive IgG serology which does not distinguish between past and persistent infections.
In older adults , gait variability may be associated with areas important for sensorimotor integration and coordination.
In older adults , however , offset-related processing was dominated by an N2 that could reflect enhanced cognitive control activities.
In older adults , it was related to higher life satisfaction among nonworking individuals and to fewer depressive symptoms among those without a steady partner.
In older adults , it was related to higher life satisfaction only among working individuals , although the difference from nonworking individuals was not significant.
In older adults , movement adjustments are generally slower and of smaller magnitude , consistent with a greater risk of falling.
In older adults , several environmental challenges can potentially trigger the onset of an episode of major depression.
In older adults , sleep did not enhance memory consolidation significantly compared to wakefulness.
In older adults , Stroop performance was associated with early as well as late adaptation whereas was not associated with adaptation.
In older adults , temporal gait variability was associated with structural differences in medial areas important for lower limb coordination and balance.
In older adults , the ability of the skeletal muscle to respond to anabolic stimuli is impaired.
In older adults , the goal of vaccination is more realistically targeted to providing clinical protection against disease rather sterilizing immunity.
In older adults , the impact of psychosocial stress on TL may be different due to the lifetime exposure to competing causes of TL-shortening.
In older adults there are few data that inform about normal ranges and the change in blood cell counts with ageing.
In older adults we found increased recruitment of areas in the fronto-parietal control network ( FPCN ) during target detection.
In older adults , when standing , compression leggings maintained MAP by elevating TPR.
In older adults with compromised function , PT leads to similar increases in strength and larger increases in power than ST.
Inolder African-American and European American subjects ( Health ABC ) H1 carriers showed a higher incidence of metabolic syndrome.
In older age , higher striatal iron was related to poorer memory.
In older and particularly frail patients , dose reduction of therapeutic paracetamol is recommended due to concerns of an increased risk of hepatotoxicity.
In older cancer patients , polypharmacy is at least as common as it is in individuals of the same age without cancer.
In older community-dwelling men , pain was robustly associated with worry about health , highlighting the potential importance of subthreshold anxiety-related psychological factors.
In older individuals , however , the reflected wave occurs earlier , reaching the heart during systole.
In older individuals , immunosenescence upregulates the innate response and , by this way , may hypothetically favor the presence of this association.
In older men , bioavailable oestradiol may play a role in the maintenance of cortical and trabecular bone mineral density ( BMD ) .
In older men bioE ( @number@ ) may maintain cortical and trabecular BMD.
In older men , however , this relationship was not observed.
In older men , interventions should consider neighborhood sidewalk design and crime.
In older men , lower serum SHBG , FSH , and LH and higher E1 levels protected against loss of BMD without increasing fracture rate.
In older men , most studies reported higher bioavailable testosterone levels to be associated with better cognitive function.
In older men the size of the sebaceous glands was increased.
In older octogenarians , the increase in hemostatic markers indicated an increase in 5-year CV mortality at follow-up.
In older participants , @number@ trials were needed to obtain a reliable FRN.
In older patients , the role of atrial fibrillation is more significant.
In older people the risks from bariatric surgery outweigh benefits.
In older people with asthma , AHR is associated with increased acinar ventilation heterogeneity , but it is unknown if this association exists in COPD.
In older persons , arterial stiffening is associated with skeletal muscle mass decline differently for race and gender.
In older persons with and without cardiovascular disease , muscular strength and endurance contribute to functional independence and quality of life , while reducing disability.
In older populations , the proportion of documented SA visits by specialists rose , and that of primary care providers decreased.
In older women , SVH without endplate fracture identified on baseline assessment may be long standing and unrelated to VF.
In older women , therefore , SVH may be largely long standing and not indicative of osteoporotic fracture.
In older women , this association ( of testosterone with cognition ) is less clear.
In old , myosin content decreased more ( p < 0.05 ) in MHC 2a vs @number@ fibers.
In old participants , serum albumin was not associated with any of the muscle measures.
In old people it may lead to orthostatic hypotension , in youth - to dizziness.
In old rat wound there is an increased of staining for TNF compared to young wound.
In one family , a proline residue within the C2B Ca2 + -binding pocket of synaptotagmin is replaced by a leucine.
In one patient overactive detrusor activity was in the same time presented with urge incontinence and treated in the same way.
In one patient the creation of a vesicovaginal fistula resolved the pyocystis completely.
In one resistant isolate no cyp51A mutation was detected.
In one study , SPT was compared with two other interventions ; in the other two studies , it was compared with three other interventions.
In only @number@ persons with microbleeds at baseline , fewer microbleeds were present at the follow-up examination.
In only one case was a heart murmur detected by auscultation.
In Ontario , CHCs refer to these activities as Community Initiatives ( CIs ) ; yet , little is known about how CIs operate.
In OO men , the HRs was @number@ for developing future MetS.
In open-ended responses , participants reported work-related changes they anticipated making in response to the training.
Inoperable cases such as dead-on-arrival and the cases with both pupils dilated were excluded.
In order to achieve these aims , care organizations might need to evaluate the use of their financial means.
In order to achieve this goal , a clear definition of the concept of elderly health is essential.
In order to address fundamental questions about adduct distribution and replication fork encounters , we combined laser localization with two other technologies.
In order to address the challenges of clear design and a user-friendly graphical user interface ( GUI ) , ViSiBooL implements visual representations of BNs.
In order to address this issue , we screened for plasma membrane-associated proteins that are preferentially expressed in senescent cells.
In order to alleviate pain and other symptoms , early countermeasures must be taken against this adverse event.
In order to analyse drug changes , medication records were collected @number@ months after the medication review or index date in the waiting-list group.
In order to analyze parameters referred to @number@ mm skin thickness , we also used @number@ MHz sonography ( DUB @number@ ) .
In order to assess the effectiveness of the application @number@ subjects , older than @number@ years old , took part in this study.
In order to avoid practice effects , the assessment of alternate forms is suggested.
In order to better evaluate the cancer burden in the two regions , it would be important to implement cancer registration.
In order to better recognise frail subjects in this specific population , four independent correlates of frailty were identified.
In order to better understand their physiological role , age-related changes of salivary amino acids were investigated.
In order to better understand this group , a large study of patients from multiple tertiary centers in the Beijing area was designed.
In order to carry out antioxidant therapy , one needs to know the contents of antioxidants in food products.
In order to characterize the endogenous expression of Beclin-1 in osteosarcoma cell lines , we performed real-time PCR and Western blot analysis.
In order to collect the data , we used the validated Orofacial Myofunctional Evaluation with Scores for Aged Protocol.
In order to correct the influence of female age-related fertility , a different analysis was performed considering only women under @number@ years of age.
In order to determine the content and face validity of the questionnaire , judgments of experts were used.
In order to develop effective rehabilitation strategies , it is indispensable to know how these different degrading factors act upon speech perception.
In order to do this adequately prescribers need to be aware of the significant differences between men and women in response to antipsychotic treatment.
In order to efficiently modify cholesterol through the life span , it is important to take into account APOE allele status.
In order to elaborate acceptance criteria , the state of the art on opinions and perceptions of elderly people about AAL technologies , is summarized.
In order to elucidate pathways downstream of PSEN1 , we characterized neural progenitor cells ( NPCs ) derived from FAD mutant PSEN1 subjects.
In order to elucidate the underlying mechanism for the senescence-associated hypo-responsiveness , we carried out the comparison study for gene expression profiles through microarray analysis.
In order to enable and enhance older persons ' self-determination , extensive knowledge of older persons ' self-determination is needed.
In order to encourage more widespread screening , the MNA-SF may be able to replace the full MNA.
In order to ensure proper cell functioning a continous communication between cell nucleus and mitochondria must be maintained.
In order to examine the longer-term effects of hazard perception training , we recruited @number@ drivers aged @number@ and over.
In order to find inhibiting agents of SASP formation , @number@ plant constituents were incubated with BJ fibroblasts for @number@ days after treatment with bleomycin.
In order to further confirm our findings , we incubated human myoblasts in exogenous CRP.
In order to help determine between the two possibilities , we analyzed the relationship between age and gait features among @number@ individuals aged 20-69.
In order to implement appropriate interventions , it is important to understand the symptoms in more detail.
In order to improve specialists ' understanding of ageing , the comparative study on personality among people at different age was designed.
In order to increase between-listeners variability in peripheral coding , participants with a wide range of age ( 20-70 years ) were included.
In order to increase HIT acceptance among older people , equipment design and organisational factors need to be considered.
In order to increase the specificity of glycogen stain , an antibody against glycogen is used.
In order to induce acidosis , acetazolamide was added to drinking water ( @number@ g / l ) of kl / kl and wild-type mice.
In order to interpret these signs , practitioners must know what is normal for a particular age.
In order to keep both processes in balance , the activity , differentiation and apoptosis of both cell types have to be tightly regulated.
In order to maintain resting energy levels , aerobic glycolysis is upregulated by redox-sensitive transcription factors.
In order to make the concepts realizable in terms of cost , it will be necessary to standardize and modularize these concepts for industrial fabrication.
In order to meet this and other challenges Bulgarian dentists have started changing their traditional solo-practice to group-practice.
In order to obtain the updated data we used the usual engines ( Pub Med and Google Scholar ) .
In order to offer a more complete training , resistance exercises have been added to HIIT ( HIIRT ) .
In order to optimize outcome in people with psychosis , prescribers should ensure that gender differences are taken into account.
In order to plan and evaluate the effectiveness of targeted interventions , valid assessments are critically needed.
In order to reduce the rate of revision surgeries , it is important to perform complete decompression and select an adequate surgical technique.
In order to remove redundant information , a novel feature selection technique was employed to single out optimized features.
In order to respond , we compared our experiences to a review of the professional and scientific literature from @number@ to @number@
In order to reveal the effect of aging on the skin maceration , we compared these parameters between young and aged rats.
In order to safely avoid obstacles , humans must rely on visual information regarding the position and shape of the object obtained in advance.
In order to support our claims , we draw parallels between technological progress and biological growth.
In order to support these needs for training about TB , JSTB began the Certification System for TB and NTM in @number@
In order to target a population as close aspossible to healthy subjects , echocardiograms reporting abnormal contraction , valvulopathy or extreme data were excluded.
In order to test the intersection assistance , eight intersections were depicted for further analyses.
In order to test this hypothesis , participants of a variety of ages were recruited into two groups.
In order to understand activity engagement in later life , insights into the extent to which activities compete with or complement each other are necessary.
In order to understand current and changing patterns of population health , there is a clear need for high-quality health indicators.
Inorganic arsenic is a known neurotoxin that has both neurodevelopmental and neurocognitive consequences.
Inorganic nitrate is converted into NO via a 2-step reduction process and may be an effective nutritional intervention to modify vascular and metabolic functions.
Inorganic nitrate supplementation did not improve BP or endothelial function.
Inorganic nitrite is a promising precursor molecule for augmenting circulating and tissue NO bioavailability because it requires only a one-step reduction to NO.
Inorganic sunscreens reflect and scatter UV and visible radiation , while organic sunscreens absorb UV radiation and then re-emit energy as heat or light.
In organ-specific amyloidoses , soluble protein oligomers are the primary cytotoxic species in the process of protein aggregation.
Inosine is a naturally occurring nucleoside degraded from adenosine.
In osteoarthritic cartilage , degenerating or necrotic chondrocytes were found.
In osteoporosis fracture group , osteoporosis with AD was more common than osteoporosis with normal cognition function.
In osteoporosis , the risk of fracture is influenced by decrease of bone mineral density and deterioration of bone quality.
In osteoporosis , the risk of fracture is influenced by decrease of bone mineral density and deterioration of bone quality.
In other networks , such as the fronto-parietal network , males and females showed divergent connectivity trajectories with age.
In otherwise healthy adults , moderate aerobic exercise extends life span and likely health span by 2-6 years.
In other words , the diagnostic test may lead to a false negative diagnosis.
In other words , they failed to inhibit the source information.
In other words , VIQ increases tended to be greatest when reading ability was high relative to VIQ.
In our aging population the incidence of cancer is increasing in the elderly.
In our case no hip abnormalites were detected.
In our conclusion , we draw attention to inequalities and the need for a life course perspective to ground future thinking.
In our criteria , we considered @number@ or more abnormal variables indicative of a high likelihood of MCI due to AD.
In our earlier research , we designed tangible tabletop games to help the elderly remember and talk about the past.
In our editorial , we put these findings in perspective and discuss implications for research and practice.
In our environment , the dietary changes and sedentariness that have led to the spectacular rise in obesity have increased the prevalence of diabetes.
In our experience , drop-out rate after @number@ months was similar in adults ( @percent@ ) and in older patients ( @percent@ ) .
In our experience , @percent@ of elderly patients had pre-operative complications.
In our experimental setting loss of APC2 form principle forebrain neurons did not affect the course of pathology in an Alzheimer's disease mouse model.
In our first experiment , we elicited adaptation by a double-step paradigm , which is designed to trigger primarily low-level , gradual motor adaptation.
In our future work , we will refine the ambient and interactive presentation and implement and evaluate this technology in residential homes.
In our model , 25-OH induced not only caspases-dependent apoptosis associated to granzyme B release but also P2X7 receptor-dependent pyroptosis in skin cells.
In our mouse model , MTO1-related OXPHOS deficiency can be bypassed by feeding a ketogenic diet.
In our murine model , addition of TNF-α at @number@ ng / mL at the fracture site accelerated healing.
In our opinion , these approaches may avoid potential negative effects of pro-senescence therapies and may also enhance the efficacy of cur-rently available immunotherapies.
In our paradigm , the participant wearing prism-equipped goggles touches their index finger to the target presented on a touchscreen in every trial.
In our patient population , the percentage of patients with group B blood declines with age.
In our population , CH decreased with aging , and men demonstrated a higher CH and CRF than women did.
In our practice we often address midface cheek hollowness or atrophy with the placement of submalar implants at the time of rhytidectomy.
In our previous study , we demonstrated a significant relationship between social functioning and prefrontal cortex ( PFC ) activity in patients with depression.
In our previous work , we demonstrated the considerable potential of this new technology.
In our review we try to find the environmental influence on the disease.
In our sample education could represent a protective factor and a marker of an enriched environment or a better developmental cognitive differentiation.
In our sample of @number@ patients , the median age was @number@ and @percent@ were robust , @percent@ were pre-frail , and @percent@ were frail.
In our sample , @percent@ of subjects had ≥ one grade 3-5 hematologic toxicity ; @percent@ had ≥ one grade 3-5 nonhematologic toxicity.
In our secondary analysis , @number@ independent dermatologists graded these photographs using @number@ validated photonumeric scales.
In our second experiment , adaptation was induced by a perceptual task that emphasizes high-level , fast processes.
In our second @number@ years of development and dissemination , we have focused on adapting EPEC to different specialties.
In our setting , not all the Vasc-MCI patients have a multiple domain profile.
In our studies these modifications were evaluated in subjects occupationally exposed to low levels of benzene and in the general population.
In our study , all functional mast cells that underwent activation and were co-localized with deposits of calcium did not contain chymase.
In our study , CaGene @number@ was more sensitive than CaGene @number@ although the latter showed a higher specificity.
In our study cohort , median ( interquartile range ) MBG was @number@ ( 383-812 ) pM.
In our study , endothelial dysfunction , assessed by ADMA levels , is associated with frailty.
In our study female sex , older age , unmarried status , living in a rural area and self-reported poverty were independent correlates of malnutrition.
In our study , @number@ of @number@ and @number@ of @number@ subjects were responsive for the 1-2- and 0-30-Hz stimulus signals , respectively.
In our study , @number@ patients with pneumococcal pneumonia were identified among these @number@ CAP patients.
In our study , @number@ subjects stood on a compliant surface with their eyes closed.
In our study serum prohepcidin levels do not correlate with any iron parameters or inflammation markers.
In our study , the administration of Goishi tea and Flos Lonicerae in animal models of disease demonstrated high functionality.
In our study , the contribution of @date@ to prostate cancer development was examined.
In our study , the occurrence of the susceptible HLA-DRB1 03 and HLA-DRB1 04 alleles in T1D patients is higher than in LADA.
In our study , we enrolled @number@ elderly patients with depressive symptoms compared to @number@ age-matched healthy controls.
In our study , we identified a reduced frequency of γ / δ T cells but not α / β T cells with aging.
In our technique , by gentle suction in anterior mediastinum , necrotic tissue resection was possible without any osteotomy need.
In ovariectomized rats , estradiol replacement attenuated Iba1 , Cd11b , Fcgr1a , C3 , increased mannose receptor Mrc1 , Cd163 and reversed Sema3a expression.
In overweight and obese survey respondents there was no significant effect of ADMP rank on interest in program participation ( p = @number@ ) .
In overweight children , oropharyngeal leak pressure was significantly greater when the laryngeal mask was sized by the patient's actual weight.
In oxygen-treated animals , all eyes injected with VEGF Trap exhibited markedly less intravitreal NV than that of hFc-injected fellow eyes , irrespective of dose.
In p53-independent cell protective pathway , we found that FOXO1 , FOXO3a , and FOXO4 were involved in SOD2's upregulation by resveratrol.
In paid home care in Chicago , older adults and their workers regularly participate in exchanges of money , time , and material goods.
In pancreatic and thyroid cancer cells , the growth-inhibitory effect of GO-Y030 was 4- and 15-fold greater , respectively , than that of curcumin.
In parabiosis assays , the paracrine senescence response underlying the DCM phenotype does not transmit to healthy mice.
In parallel , antioxidants that stimulate the antioxidant defense systems and interact with the monoaminergic system show an antidepressant-like activity.
In parallel , a number of effector mechanisms of senescence have been identified and characterized.
In parallel , ASC proliferation and efficiency of tri-lineage differentiation were evaluated.
In parallel , a significant increase in glutathione content , assessed by LC / MS analysis , was observed in both models.
In parallel , dementia and cognitive disorders also represent major healthcare and social priorities.
In parallel effort , several classes of pharmacological agents that induce fetal hemoglobin expression through molecular and cell signaling mechanisms have been identified.
In parallel , improvements in the quality control of breast cancer care have been established in specialized breast care units.
In parallel , in humans , a loss-of-function mutation of the osteocalcin receptor was associated with hypergonadotropic hypogonadism.
In parallel , in HUVECs OB-plasma increased GRP78 and activated PERK , eIF2α , IkBα and ATF6 ( all ER stress markers ) .
In parallel , integrative multi-omics investigations have generated high-resolution molecular maps of putative relevance for understanding disease initiation and progression.
In parallel , polygenic risk scores for SCZ were associated with lower general cognitive ability.
In parallel , the activity of mitochondrial Aβ-degrading enzyme PreP ( presequence peptidase ) was enhanced in Tg mAPP mitochondria expressing the ABAD decoy peptide.
In parallel , there are increasing numbers of elderly patients presenting with chronic kidney disease ( CKD ) , particularly in the more advanced stages.
In parallel , we developed an interactive website to disseminate the CNGS taxonomy to researchers and engage them in its continued refinement.
In parallel , we found enhanced alternative NF-κB activation.
In parallel , we have examined the ability of JAD to promote growth factor activities and improve skin wound healing.
In parallel , we incorporate different available data sources , such as Gene Ontology and ProteinProtein Interactions , to deliver biologically consistent results.
In parallel , we investigated DNA lesion processing by quantitative immunofluorescence microscopy of histone H2AX phosphorylated on Ser139 focus after radiomimetic treatment.
In parallel , we showed that JAD promoted FGF-7 and improved skin healing by accelerating epithelial repair in vivo.
In Parkinson disease ( PD ) brain , a progressive loss of dopaminergic neurons leads to dopamine depletion in the striatum and reduced motor function.
In part , functional polymorphisms of the SERT gene might determine the differences.
In participants at least @number@ years of age , a decrease in GFR was associated with increased CAC.
In participants who initiated statin therapy , lipophilic statins tended to reduce dementia risk more than nonlipophilic agents.
In participants with high homocysteine levels , no significant association between cholesterol and cognition was found.
In participants with low ALM / height ( @number@ ) , no associations with physical limitations were found.
In participants without dementia , only for DHI ( p < @number@ ) a significant improvement was observed.
In particular , activities geared more toward self-development , such as postretirement employment and lifelong learning , are strongly associated with lower levels of mortality.
In particular , affected women show a lower probability of being overweight , but also a higher probability of having ever smoked.
In particular , African Americans had high rates of respiratory impairment that were associated with mortality but not respiratory symptoms.
In particular , a large proportion of depressive disorders in the organic substrate is observed in people over @number@ years of age.
In particular , almost @percent@ of respondents advocated ablation for SRMs in a comorbid 75-year-old patient.
In particular , alterations in plasma AA and DHA containing PL species were also observed in the brains of E4FAD mice compared to E3FAD mice.
In particular , an imbalance between levels of acetylcholine and monoamine ( such as dopamine ) may cause delirium.
In particular , antibody levels and function are reduced in older people.
In particular a significant overall weakening of the network with age is found for wakefulness and non-REM sleep stages.
In particular , asthma and chronic obstructive pulmonary disease ( COPD ) both overlap and converge in older people.
In particular , a thinner layer between internal and external limiting membrane showed strong associations with ring-like structures.
In particular , being SRWL a memory test , both immediate recall and delayed recall were evaluated.
In particular , cancers and precursor cancer lesions exhibit aggravated age DNAm signatures.
In particular , changes in cortical thickness may index maturational progressions from an overabundance of neuropil toward efficiently pruned neural networks.
In particular , changes in target speaker usually result in declined speech perception.
In particular , cognitive impairments are frequently reported.
In particular , combining resistance exercise with essential amino acid supplementation restores the muscle protein anabolic response in older men.
In particular , complexity must be represented within research design and embraced as an important aspect of review panel critiques.
In particular , conversational turn-takings usually result in switch costs , as indicated by declined speech perception after changes in the relevant target talker.
In particular , disabilities in some specific IADL tasks seem to be especially perceived by women as undermining their quality of life.
In particular , DNA aneuploidy strongly associated with age in non-smoker OPMDs / OSCCs patients.
In particular , DPAA tends to persist in the brain for a long time , resulting in long-term impacts on the brain.
In particular , during aging , the stemness property can decrease because of enhanced apoptotic cell death and senescence.
In particular , during the aging process , hyaluronic acid , collagen , and elastin fibers undergo structural and functional changes.
In particular , early dementia patients struggle with finance tasks ; a deficit linked to impaired working memory.
In particular , epifriedelanol ( @number@ ) suppressed adriamycin-induced cellular senescence as well as replicative senescence in HDFs and HUVECs.
In particular , FA in her genu corpus callosum was higher than any FA value observed in the reference sample.
In particular , females are generally more prone to autoimmunity , but experience lower rates of infections and chronic inflammatory disease.
In particular , focus will be placed on studies evaluating the ABO phenotype in centenarians , the best human model of longevity.
In particular , G allele carriers showed increased circulating pro-inflammatory cytokines and zinc.
In particular , GC-IPL thinning was primarily associated with grey matter volume , whereas no association was found with white matter changes.
In particular , HA concentration seems to be inversely correlated to elastin gene activation.
In particular , herpesviruses have been linked with IPF.
In particular , highly conserved pathways modulate germline stem cell lineages according to nutrient availability.
In particular , H Oxidative stress alters physiological function in most biological tissues and can lead to cell death.
In particular , hypothalamic GAL has a positive , reciprocal relationship with dietary fat and alcohol.
In particular , increased expression of Polo-like kinase @number@ within neurons of older animals could contribute to phospho-Ser @number@ α-synuclein production.
In particular , increased protein intake during negative caloric balance maintains lean body mass and blood glucose production.
In particular , increased visceral and ectopic fat deposition play a major role in the development of insulin resistance and MetS.
In particular , in patient fibroblasts carrying the p.A203V mutation in SUN1 , the alterations were aggravated.
In particular , insight's association with attention and executive function observed in younger patients is attenuated by age-related changes in cognition.
In particular , intact attentional processing is integral for safe mobility and navigation.
In particular , it grows higher with increasing age , and is always higher in men than in women.
In particular , it has been shown that the CDP-choline improves the cognitive and mental performance in Alzheimer's dementia and vascular dementia.
In particular , it is not known whether inhibition of PCSK9 has any effects on very low-density lipoprotein or intermediate-density lipoprotein ( IDL ) metabolism.
In particular , it is unknown to what extent these problems may be related to changes in configural face processing.
In particular , it is unresolved how HPV-infected keratinocytes escape cell-cycle control and whether their cross-talk with immune cells is critical for tumorigenesis.
In particular , its involvement in adipose tissue tumors has never been investigated.
In particular , its over-expression seems to be able to suppress insulin / IGF-1 signaling extending life span.
In particular , language and short memory skills , frontal lobe functions , visuo-spatial abilities and adaptive behaviour appear to be the more affected domains.
In particular , LB pathology exhibited a unique distribution with extremely severe cortical involvement.
In particular , levels of adiponectin and adiponectin / resistin index significantly increased following LD-1227 administration.
In particular , LHFP appears to be a strong predictor for suicidality in males with depression.
In particular , low FT₃ levels are significantly related to all-cause and CV mortality.
In particular , MAPT mutations give rise to the subgroup of tauopathies.
In particular , Markov Chain Monte Carlo methods were used to simulate posterior distributions.
In particular , metaphorical representations in the discourses of frailty convey key cultural and clinical assumptions concerning both older bodies and old age more generally.
In particular , most studies in model organisms are conducted in strains of limited genetic diversity which are then not applicable to human populations.
In particular neurons of the spinal cord and peripheral ganglia play a key role in regulating micturition and defaecation reflexes as well as promoting continence.
In particular , nocturia is most well-controlled by @number@ mg qd.
In particular , no study has investigated the relation between strength training and cerebral perfusion.
In particular , [ @number@ ] -shogaol markedly and dose-dependently inhibited TRPC5 currents with an IC50 of value of ~18.3 µM.
In particular , nutrition , mental and physical activity impact the molecular and functional mechanisms whose alterations cause the major age-related diseases.
In particular , older adults had more difficulty and may have needed more attention to stand quietly , compared with young adults.
In particular , older adults with cognitive impairment exhibit shorter minimum distances from the marker and asymmetrical trajectories during the TUG test.
In particular , older age , being employed , and having higher SCIM scores were positively associated with health preference.
In particular , older children committed fewer errors and corrected their errors more frequently than younger children.
In particular , older drivers were five times more likely to suffer a severe injury without a seatbelt.
In particular , other than the Cys motif , the C terminus of the protein has not been intensely examined in the context of retrotransposition.
In particular , our data revealed that miR-23a could directly target the @number@ untranslated region ( @number@'UTR ) of TRF2.
In particular oxidative stress has been reported to play an important role on the process.
In particular , PA clearly reduces the risk of obesity-related diseases.
In particular , @percent@ of compressed sentences revealed a clear differentiation between moderate hearing loss and moderate-to-severe hearing loss.
In particular , phytoestrogens have been shown to reduce Alzheimer's Disease ( AD ) related pathology , potentially alleviating risk of AD progression.
In particular , PIPs mainly concern drugs acting at the central nervous system level , mostly benzodiazepines and antipsychotics.
In particular , poor perceived general health and mobility constraints contributed independently to the difference between high and low concern of falling.
In particular , population-based data are lacking regarding the factors associated with advance directive completion.
In particular , posttest data indicated new adoption of in-office screening techniques , chart documentation of driver safety concerns , and transportation alternative planning strategies.
In particular , potential state or trait effects of SOC competencies are considered.
In particular , promoting health and mobility , optimising sleep-wake cycles and increasing social support may reduce levels of psychological distress and improve QOL.
In particular , proteinuria , not decreased eGFR , is more significantly associated with DR or VTDR.
In particular , rates of cognitive disorders and late-life affective disorders are expected to increase.
In particular , recommendations that included the words \ "could \ " and \ "consider \ " were less likely to be implemented.
In particular , regarding coronary artery calcification , which is shown to can predict coronary events , it still remains unclear and controversial.
In particular , risk assessment studies suggest that type @number@ diabetes mellitus is a risk factor of Alzheimer's disease.
In particular , SAMP8 and SAMP10 show age-related impairment of learning and memory.
In particular , severity and prevalence both increase with aging.
In particular , skull thickness is thought be a very important factor governing deformation of the skull and its propensity for fracture.
In particular , soldiers often operate in a negative energy balance in stressful and demanding conditions with little opportunity for rest or recovery.
In particular , stroke and arrhythmias were more frequent in PA patients.
In particular , studies in C. elegans have pioneered the fundamental role of cilia for cystic kidney diseases.
In particular , such devices should be accepted by elderly people so that they are willing to wear it all the time.
In particular , synchrotron μCT ( SR-CT ) provides a more detailed view of trabecular structure at the nano-level.
In particular , technologies that \ "unload \ " the joint may reverse the structural damage , which is the cardinal feature of this disease.
In particular , the accumulation of conditions or agents due to inflammatory states or tissue ischemia is important.
In particular the aged brain seems to be characterized by increased levels of pro-inflammatory cytokines.
In particular , the analyses of trajectories of muscle parameters may help identify cutoffs for the estimation of risk of adverse events.
In particular , the attribution of WMLs to chronic ischemia secondary to venous collagenosis and cerebral blood flow autoregulation disruption seems reasonable.
In particular , the authors consider the relevance of this hypothesis to the ageing population.
In particular , the Brooks ' Spatial Memory task led to significantly larger step width variability only among older adults.
In particular , the cardiac interbeat interval series was quantified with respect to complexity and fractal scaling properties.
In particular , the decisions lead to the choice of the adopted instruments , and the reasons for setting the relevant thresholds are explained.
In particular , the differentiation of osteoblasts and osteoclasts is accompanied by profound changes in gene expression.
In particular , the early diagnosis and treatment of a transient post-operative thyrotoxicosis could improve recovery.
In particular , the effects of thermal stress on this film were evaluated.
In particular , the field must ensure that public health importance drives research questions , while seizing the opportunities presented by new technologies.
In particular , the frailty syndrome is increasingly being considered as a key risk indicator of adverse health outcomes.
In particular , the frequency of rs972936 GG genotype was significantly greater in AD patients than in control subjects ( @percent@ vs. @percent@ ) .
In particular , the genes and pathways demonstrating association with depressive symptoms may be potential therapeutic targets for these symptoms in older adults.
In particular , the genetic interaction of aging and age-related pathologies remain a subject of debate.
In particular , the homeostatic physiological dysregulation ( PD ) hypothesis contends that aging is caused by the progressive breakdown of key regulatory processes.
In particular , the interpretation of exploratory factor solution improved.
In particular , the inverted T CD4 : CD8 ratio has been correlated with increased morbidity and mortality across different age groups.
In particular , their roles in stem cell differentiation have been well documented.
In particular , the linkage between increasing white matter hyperintensities and LUT dysfunction during aging is recognized but not understood.
In particular , the memory-spared MOD-VISP cluster was associated with younger age , APOE e4 negative genotype and prominent atrophy of the posterior cortex.
In particular , the old group showed a notable decrease in the connector ratio and the intermodule connections.
In particular , the place of informal caregivers needs to be reevaluated.
In particular , the Ppp1r1b gene is associated with the inhibition of dopamine releases , which decreases the motivation for learning.
In particular , the prediction of clearance or dose in an individual patient remains highly erratic.
In particular , the presence of pre-S2 deletion mutants is an important risk factor associated with cirrhosis and HCC.
In particular , the proportions of smaller lung cancers , lung adenocarcinomas with ground-glass opacity , and lung cancers in older patients are increasing.
In particular , there is an emerging literature regarding the questionable efficacy of vitamin K supplementation in reducing age-related bone loss.
In particular , the review focuses on research exploring age , culture , gender , and special populations.
In particular , there was extremely limited evidence on use and efficacy of these devices within this population.
In particular the roles of redox signalling and HSPs in regulation of inflammatory pathways appears important in their impact on organismal ageing.
In particular , these patients have more diseases including dementia and medications that put them specifically at higher risk of delirium.
In particular , the treatment benefits of lower dyskinesia rates and improved adherence influenced the cost-effectiveness outcome.
In particular the vulnerable subgroup of older workers with chronic disease and low psychosocial resources at work is more likely to quit working.
In particular , this age group is more vulnerable to adverse drug events because of the physiological changes that occur due to senescence.
In particular , this can facilitate the identification and treatment of associated extracutaneous disease.
In particular , this manuscript will focus on Alzheimer's disease ( AD ) and considerations when dealing with new treatment options.
In particular , this pathway has been implicated in cell fate determination , proliferation and cell polarity establishment.
In particular , this present study shows that a support group can reduce depressive symptoms for participants.
In particular , this study sought to assess the impact of an ' Enhanced ' Program intended to facilitate aging in place.
In particular , thyroid hormones affect the reproductive function both directly and indirectly through several actions.
In particular , transcriptional silencing at rDNA was restored , extrachromosomal rDNA circles formation was repressed and histone acetylation at H3K9 and H4K16 decreased.
In particular , TREM2 Q33X , R47H , T66M , and S116C mutations were found in FTD and were absent in HCs.
In particular , two clusters of hairpins ( near the D-loop @number@'-terminus and the L-strand origin of replication ) are hotspots for mtDNA breakage.
In particular two groups were enrolled : @number@ patients > or = 65 years old and @number@ patients < 65 years old.
In particular , UVB irradiation increases matrix metalloproteinase ( MMP ) -1 production and collagen degradation , leading to premature aging , termed photoaging.
In particular , UVB radiation causes formation of specific DNA damage photoproducts between pyrimidine bases.
In particular , very old MCI patients were more frequently classified as having multiple-domain amnestic MCI.
In particular , vitamin D is important for a range of vital cellular processes including cellular differentiation , proliferation and apoptosis.
In particular , voiding domain was more affected than storage domain.
In particular , we aimed to examine whether Scandinavian data support the theory that mortality reaches a plateau at particularly old ages.
In particular , we asked whether participants can use patterns arising from differential distributions of intertarget lags across trials to predict the arrival of T2.
In particular , we assume that increased transcallosal PT connectivity might promote functional specialization and asymmetry of homotopic brain regions.
In particular , we describe that deregulation ofDNA methylation and histone modifications can occur in the immune system and lead to rheumatoid arthritis.
In particular , we employed various behavioral memory paradigms that allow the disentanglement of hippocampus-dependent and -independent memory.
In particular , we explored postural sway on a ship at sea when older adults looked at the horizon or at nearby targets.
In particular , we focused on lncRNAs regulated by androgen receptor and expressed in castration-resistant prostate cancer.
In particular , we focus on mechanisms by which inflammation , oxidative stress , and oncogenic stress accelerate cellular senescence.
In particular , weight loss can lead to numerous adverse health outcomes affecting daily activities , loss of functional status , and increased mortality.
In particular , we model volumetric changes in @number@ bilateral ROIs , which cover large portions of cortical and subcortical gray matter.
In particular , we reviewed existing literature , reanalyzed some of our data , and combined results graphically.
In particular , we show that FUST-1 and PAB-1 co-localize in aberrant cytoplasmic accumulations.
In particular , we show that the model of heterogeneous population fits mortality data better than other commonly used mortality models.
In particular , we try to dissect these pathways and also examine cross-talk between different signalling pathways.
In particular , we unravel novel putative mechanisms to link circadian clocks to healthy aging.
In particular , we wanted to determine a more effective method of ASC application and the fate of the photo-aged fibroblasts.
In particular , we were interested to see if the limit was exceeded.
In particular , when Trp was next to an Asp residue on the C-terminal side of the peptide , the racemization reaction was accelerated.
In particular , women did not want to die in a hospital.
In particular , women who lived alone showed high adjusted OR ( @number@ @percent@ CI @number@ @date@ ) .
In particular , young adults demonstrated implicit biases favouring general , as compared to sexual , activities and young adults as compared to older adults.
In part @number@ the influence of the magnification devices was investigated for all dentists.
In pathological condition the affection of C3-C4 and C4-C5 intervertebral foramina was more due to narrower surface area.
In-patient bed-day use increased slightly , as did the mean length of stay.
Inpatient care for patients with active GCA will total about US $ 1 billion.
Inpatient costs accounted for @percent@ of the total.
Inpatient geriatric rehabilitation appeared to have a positive effect on physical performance and the experience of pain in elderly people.
Inpatient length of stay was comparable between groups.
Inpatient medical units in a teaching , acute care hospital.
In-patient mortality was @percent@.
In patients aged 30-39 , 40-49 , 50-59 , 60-69 and 70-79 years , E ' was similar in both genders.
In patients aged > 75 years , the incidence of overall cognitive decline @number@ months postoperatively was @percent@ ( @percent@ CI : @date@ ) .
In patients aged between @number@ and @number@ or more than @number@ years there was an increased incidence ( P < 0.001 for both ) .
In patients at risk for this complication , it is recommended to obtain a bone density evaluation and to start appropriate treatment.
In patients , CMI number tended to be related to microbleed number ( p = @number@ ) .
In patients older than @number@ years , old test results increased moderately ( P < 0·003 ) .
In patients reaching CCR after chemotherapy , telomere shortening was less pronounced than in persistence or relapse but still significantly shortened compared to controls.
In patients receiving permanent cardiac electrical stimulation , a high burden of apical right ventricular pacing is associated with an increased incidence of heart failure.
In patients taking antidepressants , nocturnal SOREMPs occurred much less frequently ( @percent@ vs. @percent@ , p < @number@ ) .
In patients taking vitamin D supplements , using different cutoffs for 25-hydroxyvitamin D or competing risk models did not materially change the results.
In patients undergoing coronary angiography , the NLR is independently associated with the prevalence and severity of CAD.
In patients undergoing major procedures ( n = @number@ @number@ @number@ studies ) , @number@ frailty instruments were evaluated.
In patients undergoing minimally invasive procedures ( n = @number@ @number@ studies ) , @number@ frailty instruments were evaluated.
Inpatients were separated into @number@ groups based on the occurrence or not of death during the hospital stay.
In patients who died , neuropathologically determined neuritic plaque levels were used to confirm scan interpretations and determine sensitivity and specificity.
In patients who undergo endoscopic resection of early gastric cancer , H. pylori eradication reduces the incidence of metachronous tumors.
In patients with a congenitally weak skeletal structure , the skeleton may be the primary cause for the manifestations of premature aging.
In patients with AD , this plasticity is impaired such that a \ "seizures beget seizures \ " situation does not occur.
In patients with Alzheimer's disease , seizures can hasten cognitive decline , highlighting the clinical relevance of early recognition and treatment.
In patients with AMD , nanosecond laser treatment reduced drusen load at @number@ yr.
In patients with arterial disease , HPA axis activity showed reduced variability with older age , independent of cardiovascular risk factors.
In patients with atrial fibrillation , these rates ranged from @percent@ ( @percent@ CI 32-77 ) to @percent@ ( @percent@ CI 39-91% ) .
In patients with breakthrough IPA during posaconazole prophylaxis liposomal amphotericin B is the drug of choice.
In patients with cardiovascular disease , frailty is about three times more prevalent than among elderly persons without.
In patients with CD4⁺ T cells ≥ @number@ per microliter , alterations were less pronounced and were reversible with cART.
In patients with chronic HF , prevalence of DM is @percent@ compared with @percent@ in those hospitalized with worsening HF.
In patients with chronic kidney disease ( CKD ) , circulating FGF23 levels are markedly elevated , while Klotho production is decreased.
In patients with chronic kidney disease ( CKD ) , phosphate retention is seen universally and has been associated with increased mortality risk.
In patients with chronic neurodegenerative disorders , symptoms , such as depression and apathy , are often treated with drugs that elevate biogenic amine levels.
In patients with CKD , paroxysmal AF was independently associated with higher mortality after adjustment but not persistent or permanent AF.
In patients with cognitive complaints and participation restrictions , cognitive rehabilitation was proposed.
In patients with dementia , they have an opposite effect to inhibitors of acetylcholinesterase.
In patients with dementia , vocalizations , facial expressions and body movements may be the only valid expressions of pain.
In patients with divergent IGF1 / GH levels , fasting glucose and GH were both strongly associated with IGF1.
In patients with DM , ED can be considered as a useful sign of silent myocardial ischemia.
In patients with ethnic skin ( ie , skin of color ) , energy devices are used more cautiously to avoid adverse events.
In patients with hemiparkinsonism , L-dopa is likely to facilitate a compensation of functional abnormalities possibly through an increased thalamic FC.
In patients with hydronephrosis , TREM1 positive cells were observed in renal tissue.
In patients with left MTLE , a downsized network of frontal and temporal regions centered on the right amygdala was present.
In patients with malaria , parasitaemia is usually estimated by assuming @number@ white cell counts ( WCC ) per microlitre of blood.
In patients with melanoma treated with the BRAF inhibitor vemurafenib , Wnt5A expression correlates with clinical response and therapy resistance.
In patients with morgagnian cataract cortex liquefies and lens core hardens and becomes cloudy.
In patients with multiple infarcts on CMR , acuity was determined with T2-weighted imaging and / or evidence of microvascular obstruction.
In patients with non-thymoma-related MG , thymectomy prevented the antibody titer elevation.
In patients with OSA , the elderly group had a poorer sleep quality and more severe nocturnal oxygen desaturation than the younger group.
In patients without AS , AD decreased with age in all aortic regions ( P < @number@ ) .
In patients without large hematomas , coiling of the ruptured aneurysm represents the procedure with high effectiveness.
In patients without posaconazole prophylaxis empiric caspofungin will be considered.
In patients with RA , calcification in all vascular beds significantly increased over @number@ years and was independently associated with age and SBP.
In patients with sAD , regulation was stage- and region-dependent and not merely acceleration and exacerbation of mRNA regulation with aging.
In patients with spinal cord injury , the level of injury significantly correlates with the extent of reduced caloric energy expenditure.
In patients with stably restored immunity , KS remained significantly more frequent than in the general population.
In patients with the @number@ bp deletion , the deletion level decreased as the cancer stage advanced ( p = @number@ ) .
In patients with these attributes , conservative treatment might be a reasonable alternative.
In patients with uncontrolled or untreated hypertension , alfuzosin @number@ mg alone or combined with antihypertensive therapy significantly decreased systolic and diastolic BP.
In PBMCs , the levels of cytokines were detectable but did not either show any correlation with cognitive scores.
In PC12 cells , deletion of endogenous Rhes decreases autophagy , whereas Rhes overexpression activates autophagy.
In PD however , increased NADPH production was only seen in the affected areas of late-stage cases.
In PD patients , 5-HT ( 1B ) -receptor availability in the right orbitofrontal cortex was lower than in control subjects.
In PD studies with comparators , peritonitis risks and technique survival rates were similar across home care assisted patients and comparators.
In pediatric patients , musculoskeletal overuse injuries are common clinical complaints.
In people with stable or declining trajectories , a higher number of depressive symptoms and the presence of cardiovascular diseases were associated with worse memory.
In @percent@ at least one-sided limited visibility was observed.
In @percent@ of all cases the area between the right and left mitral isthmus lines was completely smooth.
In @percent@ of cases fluticasone was discontinued at the time of diagnosis of adrenal insufficiency / Cushing syndrome.
In @percent@ of golfers , preoperative back and / or leg pain significantly affected their ability to play golf.
In @percent@ of liquidators the main disease was primarily detected after working on CNPP.
In @percent@ of patients , the malignant disease was confined to the primitive organ of origin without secondary dissemination.
In @percent@ of the cases , good to excellent aesthetic results were achieved.
In @percent@ of the cases , the IDS layer left adhered on the tooth surface after fracture tests.
In @percent@ of the documented cases , the perpetrator was known to the victim , and a family member in @percent@.
In @percent@ of the respondents with early-onset disability fatigue , pain and depressive feelings co-occurred.
In @percent@ of the study population major therapeutic conflicts , in @percent@ of the patients minor therapeutic conflicts occurred.
In @percent@ of the trials , the subjects experienced a mechanical perturbation on the lower lip.
In @percent@ of those patient-days , at least one alert was judged to be clinically relevant.
In @percent@ partial or total thyroidectomy was conducted simultaneously.
In @percent@ , WHtR was ≥0.6.
In period @number@ ( 2005-2012 ) , this association remained stable for functional and severe ADL impairment and decreased for moderate-to-severe ADL impairment.
In periods of significant changes in the hormonal milieu ( puberty and menopause ) , sex differences may become more evident.
In-person interviews focus on neighborhood characteristics , physical and cognitive function , depression , and walking.
In-person interviews were conducted in @number@ adults ages ≥65 years.
In-person license renewal requirements were associated with reduced risk for fatal crashes.
In persons 65-75 years old , the incidence of memory complaints was @percent@.
In persons not exposed to As , As does not contribute late-onset hypogonadism.
In persons using antihypertensive medication , elevated BP is associated with a paradoxical slower GFR decline.
In persons without dementia , no significant decline in ADLs over time was present , nor was multimorbidity related to the decline rate.
In persons without dementia , preexisting cerebral WMHs , general and hippocampal atrophy may not predispose to postoperative delirium or worsen its severity.
In phase @number@ anosmics , hyposmics and controls were tested with the 16-items version of the ETOC.
In Phase @number@ antidepressant treatment is continued with the addition of randomized , double-blind treatment with donepezil or placebo.
In phase @number@ a short version of the ETOC was developed : patients with and controls without olfactory impairment were tested on a 6-items ETOC.
In Phase @number@ DEP-CI patients receive optimized antidepressant treatment for @number@ weeks.
In phase @number@ group A underwent the intervention with group B as the control.
In phase @number@ group B underwent the intervention with group A as the control.
In phase @number@ LDA provided @number@ % correct classification.
In phase @number@ linear discriminant analysis ( LDA ) of ETOC scores classified patients and controls with @number@ % accuracy.
In phase @number@ @number@ individuals consumed a low-sodium diet for @number@ wk. Participants were provided all foods , snacks , and calorie-containing drinks.
In phase @number@ older participants adopted several strategies , such as \ "letting sleeping dogs lie \ " and \ "cutting corners. \ "
In phase @number@ only the practical feasibility has been addressed for visual rating of MTA.
In phase @number@ we identified three program inputs : formative research , a community best-practices model , and an evidence-based intervention tested in non-Latinas.
In phase @number@ we implemented and monitored the program and trial.
In phase two , staff undertook the ' Getting to Know Me ' training programme ( n = 71 ) .
In photo-aged murine skin , K6EAA-L12 increased stratum corneum integrity by increasing corneodesmosome density and improved the barrier recovery rate.
In photodamaged skin , a decrease of the mature collagen crosslink was reported.
In piriform cortex , CRF1 binding increased in females and decreased in males , again becoming sexually dimorphic.
In placental tissue , methylation patterns of most targets on the mitochondrial-telomere axis were not strongly influenced by sample location.
In plants , the cytotoxic properties of quinones serve in their defensive roles against invading bacteria , fungi and parasites.
In PN , a positive correlation between CBF and neuromotor outcome was demonstrated in this area.
In podocyte-specific Arf6 ( ARF6 PodKO ) knockout mice , ARF6 deficiency did not result in a spontaneous kidney developmental phenotype or proteinuria after aging.
In polarized epithelial cells , SVBP accumulated on the apical side , whereas VASH1 was present throughout the cells and partially colocalized with SVBP.
In POLG1 and PINK1 carriers , the syndrome was recurrent and was fatal in three.
In pooled analyses of ER-negative cancers , @number@ gene sets were associated with prognosis and @number@ were associated with response.
In population terms , patients with CD have increased risk of fracture compared with the general population.
In post hoc analyses , personal control was inversely related to dichotomized medication adherence and necessity-concern differential was directly related to dichotomized medication adherence.
In post-menopausal women , behaviors that reflect active coping strategies were related to better autonomic regulation.
In postmenopausal women , manually modified contours led to generally higher cortical bone properties when compared to the automated method.
In practice , a protein biomarker in a urinary bladder cancer patient's urine was successfully measured using this technique.
In practice , there are often missing values in multivariate data.
In practice , the regulating statute is made subordinate and consequently patient safety can be threatened.
In preclinical studies , the agent has antitumor activity in a variety of docetaxel-refractory in vitro and in vivo models.
In Predicting age-specific metabolism is important for evaluating age-related drug and chemical sensitivity.
In predicting these adverse outcomes over time , gait speed was at least as sensible as composite tools.
In preimplantation mammalian embryos , telomerase activity is present from the morula stage onward and is associated with an increase in telomere length in blastocysts.
In preliminary studies , antioxidant vitamins and amino acids with antioxidant or anti-inflammatory properties show potential to restore the anabolic response associated with protein ingestion.
In premenopausal women , age is related to WE and MIF.
In prenatal and early postnatal development , plasticity allows for the formation of organized nervous system circuitry and the establishment of functional networks.
In presence of intense sleep complaints in inadequacy with somatic examination , and not documented by sleep recordings , depression must be evoked.
In present study , the in vitro and in vivo antioxidant activity of Bifidobacterium animalis @number@ was investigated.
In present study , we examine a hypothesis whether the conditioned medium from senescent cells ( CM-old ) may promote premature senescence of young MESCs.
In pretest and posttest , we assessed cognitive performance and variability of minimum foot clearance , stride time , and stride length while walking.
In previous studies , extract from Artocarpus incisus's heartwood ( breadfruit tree ) had antioxidant and antimelanogenic activities.
In previous studies , neurogenesis was stimulated by 1-methyl-4-phenyl-1 , 2 , 3 , 6-tetrahydropyridine hydrochloride ( MPTP ) in young animals.
In previous studies , we have identified global AR binding sites and AR target genes in prostate cancer cells.
In primary human aortic smooth muscle cells , acidotic environment prevented phosphate-induced alkaline phosphatase mRNA expression.
In primary human dermal fibroblasts ( HDF ) from both photoprotected and photoexposed sites , 11β-HSD1 also increased with donor age.
In primary human keratinocytes , we found that hypochlorite ( HOCl ) reversibly inhibited the expression of CCL2 and SOD2 , two NF-κB-dependent genes.
In primary mesencephalic cultures , pesticide-induced apoptosis was prevented by inhibition of nitric oxide synthase ( NOS ) .
In primary progressive aphasia ( PPA ) , speech and language difficulties are caused by neurodegeneration of specific brain networks.
In primary rat hippocampal cultures , CP-dependent proteolysis and activation of CN was stimulated by application of oligomeric Aβ ( ( 1-42 ) ) peptides.
In principle , the activity of any pathological process can be studied , as long as an appropriate radiotracer can be developed.
In prison , older prisoners cost approximately three times as much as younger prisoners to incarcerate , largely because of healthcare costs.
In proliferating cells chromatin is maintained in conjunction with DNA replication , but how non-proliferating cells maintain chromatin structure is poorly understood.
In proliferating cells DNA double strand breaks ( DSBs ) are a common occurrence during DNA replication.
In proliferating compartments , cyclin E-Cdk2 phosphorylates Lin proteins within the DREAM complex.
In proliferating normal cells , etoposide caused senescence ( cells could not resume proliferation after removal of etoposide ) .
In proportional regression analysis , knee pain severity increased with BML severity in any compartment and in the medial compartment.
In protecting from α-synuclein neurotoxicity , NCEH-1 also stimulates cholesterol-derived neurosteroid formation and lowers cellular reactive oxygen species in mitochondria.
In protocol @number@ global and regional strain and twist and torsion were measured in @number@ healthy subjects using 3D STE.
In PSP , the UPR was primarily activated in the pons and medulla and to a much lesser extent in the hippocampus.
In PSP versus others , a proposed \ "best \ " cut-off of TrMP = @number@ resulted in @percent@ sensitivity and @percent@ specificity.
In psychosis , multisensory therapy , reminiscence and virtual cognitive stimulation showed some benefits.
In pull-down experiments , we identified RNA-binding proteins , RNA helicases and splicing factors as interaction partners of NKAP , among them FUS / TLS.
Input to and output from the endoneurial microenvironment occurs via blood-nerve exchange and convective endoneurial fluid flow driven by a proximo-distal hydrostatic pressure gradient.
In quiescence caused by serum starvation , mTOR is deactivated.
In rabbit aortas , transWSS patterns were again different from patterns of traditional metrics.
In race and gender comparisons , more males than females experienced alcohol problems.
In radiological OA analysis , the Lane scale was employed in the lumbar region and the Kellgren-Lawrence scale in the knee joint.
In rapidly dividing cells , telomere length is maintained by the activity of telomerase.
In rare cases , a hereditary factor has been described : Lynch's syndrome.
In rare cases , probably because of additional mutational events , selfish spermatogonial selection may lead to spermatocytic seminoma.
In rats , sheep and nonhuman primates , reproductive capacity is altered by challenges experienced during critical periods of development.
In reality , contraction of the lower layers of the skin and swelling of the upper layers will happen simultaneously.
In reality , however , there are many situations that require binding multiple features together simultaneously.
In receiver operating characteristics analyses , BFCS volume provided significantly more accurate classification into amyloid-negative and -positive categories than hippocampus volume.
In recent decades , the concept of LOH in ageing men has become familiar in European countries and the United States.
In recent decades the population of both elderly men and women has grown substantially worldwide.
In recently menopausal women not using hormone therapy ( HT ) , significant racial differences in skin wrinkling and rigidity exist.
In recent times , several medical societies have discredited its use.
In recent years , a constant growth of knowledge and clinical applications of stem cells have been observed.
In recent years , an increasing number of new drugs with targeted action have been designed.
In recent years , a ' silent ' chronic kidney disease ( CKD ) epidemic has been proposed by many authors.
In recent years complexity of the brain structure in healthy and disordered subjects has been studied increasingly.
In recent years considerable efforts have been undertaken in order to develop new therapies for ICH and to assess them in randomized controlled trials.
In recent years , evidence has accumulated that incriminates AGEs in pathogenic processes associated with both chronic hyperglycaemia and age-related diseases.
In recent years , evidence has emerged for a bidirectional relationship between sleep and neurological and psychiatric disorders.
In recent years , H2S has been reported to exhibit a diverse range of pharmacological effects in biological systems.
In recent years immunohistological studies had become very popular in all fields of medicine including orthodontics , too.
In recent years , important progress has been made in uncovering the regulatory elements and transcriptional factors that guide the expression of these genes.
In recent years , increasing attention has been devoted to anti-aging therapies.
In recent years , increasing evidence suggests that the disulfide proteome is made up of structural disulfides and reversible disulfides.
In recent years , injections with filler agents are often used for wrinkle-treatment and soft tissue augmentation by dermatologists and plastic surgeons.
In recent years , it has become clear that fibroblasts from different tissues have various distinct traits.
In recent years , it has been found that many other drugs besides diazepam , can be classified as drugs which exhibit vertical allometry.
In recent years , it has been shown that RCNA is carefully orchestrated by a series of histone modifications , histone chaperones and histone-modifying enzymes.
In recent years , many efforts have been spent to identify sensitive biomarkers able to improve the accuracy of Alzheimer's disease ( AD ) diagnosis.
In recent years , many genetic variants have been identified in association with AM and ANM in genome-wide association studies among European populations.
In recent years , miRNA-based gene therapy through gene regulation has been considered a potential therapeutic method.
In recent years , mirtazapine has gained attention not only for its antidepressant effects , but also for its potential benefits in underweight patients.
In recent years , molecular mechanisms of MM have been revealed by microarrays ( Gene Expression Profiles ) and whole genome sequencing using next-generation sequencers.
In recent years , neurogenetic workup has provided valuable insights with numerous genes characterized and yet more new genes on the threshold.
In recent years new drugs have been licensed to treat patients with VTE called direct oral anticoagulants.
In recent years , new percutaneous therapies have been developed to complement current established treatments for acute / decompensated and chronic HF and minimize risks.
In recent years , novel clinical , biochemical , and imaging tools have been developed to improve the assessment of fracture risk.
In recent years , novel model systems have made significant contributions to our understanding of the processes that control the ageing of whole organisms.
In recent years , peroxisomes have emerged as important intracellular hubs for redox- , lipid- , inflammatory- , and nucleic acid-mediated signaling pathways.
In recent years , pioneering spiritual-care training programs and services have been developed in Israel.
In recent years , radiofrequency catheter ablation has been widely performed as an effective treatment for recurrent , drug-refractory AF.
In recent years , residential care has become an alternative option for elder care in Beijing , China.
In recent years , resistance to triazoles , the mainstay of IA therapy , has emerged in different countries worldwide.
In recent years , secreted extracellular vesicles ( EVs ) have been identified as a particularly novel vector by which cell-to-cell communications are enacted.
In recent years , several genetic pathways and biochemical processes controlling the rate of aging have been identified and proposed as aging hallmarks.
In recent years , several guidelines and standards have been developed to facilitate the transfer of this scientific knowledge into practice.
In recent years , several studies have shown that OSA potentially contributes to functional decline , mainly prompted by chronic intermittent hypoxia and sleep fragmentation.
In recent years , the aging population has been growing , and the operative techniques and anesthetic methods have advanced.
In recent years , the complex relationship between frailty and cognitive functioning has been increasingly investigated.
In recent years , the dual task paradigm has been widely used as an experimental method to explore the interplay between gait and cognition.
In recent years , the placebo effect has been a topic of considerable interest both in the scientific and the clinical community.
In recent years , the prevalence of cardiac hypertrophy has increased due to obesity and an aging population.
In recent years , the progression made in genetics has considerably contributed to our knowledge , by identifying several novel PD genes.
In recent years there has been an exponential increase of fillers use in aesthetic medicine.
In recent years , there has been considerable research focused on effective dietary interventions that may prevent or ameliorate ARCD and dementia.
In recent years , there has been increasing concern over the possibility of a radiological or nuclear incident occurring somewhere in the world.
In recent years there has been much interest in the use of optical diagnostics in cancer detection.
In recent years , the role of acetylation has gained ground as an essential modulator of intermediary metabolism in skeletal muscle.
In recent years , the role of autophagy in hypoxic myocardial injury has attracted much attention.
In recent years , the role of mTORC1 in regulating aging is gradually recognized.
In recent years the vital role of post-translational modifications of DNA repair proteins , including ubiquitylation and phosphorylation , has been uncovered.
In recent years , two major factors have greatly contributed to improve the outcomes of treatment for esophageal cancer in Japan.
In recent years , uncontrolled manifold ( UCM ) analysis has emerged as an important method to study variability of human movements.
In recent years , we have witnessed a rapid surge in assisted living technologies due to a rapidly aging society.
In recent years with the age pyramid inversion , there has been a high prevalence of SCI in the elderly.
In recognition of this deficit in total fibre intake , food manufacturing processes increasingly utilise fibre extracts and concentrates as food additives.
In recurrencies , a successful result was obtained in @number@ lids ( @number@ % ) .
In regions with environmental resistance rates of ≥10% , a voriconazole-echinocandin combination or L-AmB were favoured as initial therapy.
In regression models , job tenure was a primary driver of CO musculoskeletal outcomes.
In relation to dementia , the roles of astrocytes in Aβ deposition and clearance are unclear.
In relation with health challenges , chronic disease and disability are the two most important problems.
In remote Aboriginal communities , high prevalence rates of dementia at relatively young ages have been reported.
In renal failure , hyperphosphatemia occurs despite a marked elevation in serum fibroblast growth factor ( FGF ) -23.
In research settings , mild neurocognitive disorder ( MND ) and so-called asymptomatic neurocognitive impairment ( ANI ) are now more common than HIV-associated dementia.
In ' resilient older people ' adaptive strategies can lead to achievement of life satisfaction despite repeated depressive episodes.
In response , many European governments started to reform healthcare during the 1990s , replacing the traditional logic of medical professionalism with business-like logics.
In response , the unfolded protein response ( UPR ) attempts to restore ER function by attenuating protein synthesis and inducing chaperone expression.
In response to 7-HC , NRF2 protein translocates from cytosol to the nuclei.
In response to a balance disturbance , older individuals often require multiple steps to prevent a fall.
In response to acute genotoxic stress , p53-mediated repression of myogenin reduces post-mitotic nuclear abnormalities in terminally differentiated cells.
In response to a thermal stress , skin blood flow ( BF ) increases to protect the skin from damage.
In response to a variety of stresses , mammalian cells undergo a persistent proliferative arrest known as cellular senescence.
In response to bed rest , SCAAT glucose uptake significantly increased in CON subjects but not in FDR subjects.
In response to cold stress , a reflex increase in sympathetic nervous system activity mediates reductions in skin blood flow.
In response to DNA damage , a cell can be forced to permanently exit the cell cycle and become senescent.
In response to GLP-1 infusion , insulin levels fell progressively throughout the @number@ months.
In response to hyperglycemia , control ECFCs activated p38MAPK , which was required for hyperglycemia-induced senescence.
In response to hypoxia or mitochondrial oxidative stress , receptor-mediated mitophagy was found to be activated via both transcriptional and post-translational modification.
In response to lipopolysaccharide ( LPS ) challenge , senescent ECs demonstrate exacerbated permeability responses compared with control \ "young \ " ECs.
In response to myocardial infarction ( MI ) , time-dependent leukocyte infiltration is critical to program the acute inflammatory response.
In response to oxidative attack , cells have developed an antioxidant defense system to maintain cellular redox homeostasis and to protect cells from damage.
In response to oxidative challenge , progeric cells showed increased mRNA levels for mitochondrial superoxide dismutase ( SOD ) and SOD protein content.
In response to paraquat stress , young individuals generated more ROS and activated signaling pathways including p-ERK , p-AKT and p-AMPKα / β.
In response to Scenario @number@ Personal Avoidance and Fear of Labelling were associated with intentions to delay help-seeking.
In response to surgery , frail participants exhibited greater improvement in these patient-centered outcomes than non-frail peers.
In response to this enormous unmet clinical need , new promising therapies are being developed and evaluated in clinical trials.
In response to this evidence , key organizations and stakeholders have published guidance and framework to ensure that best practice in FLSs is delivered.
In response to UVB irradiation , LKB1 together with NUAK1 phosphorylates CDKN1A regulating the DNA damage response.
In response , we proposed an integrated information system solution.
In results , all FTLD-TDP patients displayed marked depletion of VGLUT-1-positive axon terminals in the caudate head and putamen.
In reverse , Tcad protein is visibly reduced from cardiac tissue in Adipo-KO mice , suggesting interdependent regulation of the @number@ proteins.
In rhesus monkeys long-term CR reduces the incidence of type @number@ diabetes , cardiovascular disease and cancer , and protects against age-associated sarcopenia and neurodegeneration.
In rheumatoid arthritis , the subpopulation of CD14bright / CD16 + monocyte is expanded and prone towards generation of Th17 cells.
In road runners , the age-related performance decline has been well investigated for marathoners , but little is known for half-marathoners.
In ROC analysis , the area under the curve was @number@ and @number@ for 1- and 2-year mortality , respectively.
In ROC , with a higher urban-rural socio-economic gradient , peripheral artery disease is more frequent in the urban areas.
In rodents , caloric restriction ( CR ) extends lifespan by up to @percent@.
In rodents , exercise-induced muscle injury is a hallmark for sequential events leading to muscle fiber necrosis and sarcopenia.
In rodents , immature calyces of Held appear in MNTB during the first few days of postnatal life.
In rodents , inhibition of this pathway causes selective dopaminergic cell death leading to motor deficits resembling parkinsonism.
In rodents , place cells replay recently travelled routes , especially during periods of behavioural inactivity ( sleep / wakeful rest ) .
In rodents , renin-angiotensin system blockade ( RAS blockade ) increases survival and prevents age-associated changes.
In rodents , the muscle anabolic resistance observed during ageing and sarcopenia has been ascribed to the development of the LGI.
In rodent vestibular epithelia , extrusion of live HCs from the sensory epithelium may be the predominant form of cell demise during chronic ototoxicity.
In round @number@ key areas of spasticity assessment and associated outcome measures were identified.
In routine screening application , gFOBTs are expected to miss more than @number@ out of @number@ advanced adenomas and @number@ out of @number@ cancers.
In R-square analysis , age had a homogeneous influence on sensory axon excitability but heterogeneous influence on motor axon excitability.
In rural areas , the unhealthy weight burden was largely underweight at all ages.
In rural Ghana , IL-10 gene variants associated with different production capacities of IL-10 and TNF-α are enriched compared with Caucasian populations.
In rural residents , subjective well-being significantly increased with the positive effect of the social network.
In Saccharomyces cerevisiae , the HSF binds to the @number@ upstream region of YGR146C and activates its transcription.
In salt-sensitive rats , spermidine supplementation also delays the development of hypertensive heart disease , coinciding with reduced arterial blood pressure.
In samples from younger individuals , the correlation of age and D-aspartic acid content was closer than in samples from older individuals.
In schizophrenia , the age effect was similarly linear in younger patients but a decline did not occur in older patients.
In search for a possible mechanism , we found that enzymatic cleavage of Tcad with phospholipase C increases plasma Adipo while decreasing tissue-bound levels.
In secondary analyses , GDS total score was replaced with the three factor scores in repeated models.
In secondary analyses , vaccenic acid was inversely associated with diabetes ( HR : @number@ @percent@ CI : @number@ @number@ P-trend = @number@ ) .
In secondary analyses , we evaluated associations of nut consumption with cause-specific mortality.
In secondary analyses , we examined associations with additional quantitative motor traits and postmortem indices , including substantia nigra Lewy bodies and neuronal loss.
In secondary analyses , we explored the relation with vascular risk factors and cardiovascular disease.
In secondary analyses , we stratified participants by age-decade and tested for linear trend across age groups.
In second phase , @number@ volunteers were evaluated , representing the four quartiles of fat percentage.
In seeking to ameliorate ageing and age-related diseases , the search for anti-ageing drugs has been of much interest.
In seeking to answer these questions the authors position the perspectives and experiences of people with dementia as central to their analysis.
In seemingly healthy , motivated individuals , fatigue and fatigability were common and may affect socially meaningful mobility behaviors.
In selecting a treatment option for AK , dermatologists should consider post-treatment cosmesis , because cosmetic outcomes differ across AK treatments.
In senescent cells , this selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis.
In separate experiments , the effects of anesthesia and the cytokine response ( IL-6 ) following surgery were evaluated.
In separate models , GBTM identified eight discrete total weight change groups , five fat mass change groups , and six LM change groups.
In septal cartilage , glycosaminoglycans decreased @percent@ per year ( P < @number@ ) .
In September and @date@ , @number@ semi-structured interviews were held with the division heads and other workers with a minimum age of @number@ years.
Insertion of a prosthesis inside the native valve is appearing more and more a valuable option rather than a bail out procedure.
Insertion site of tendinopathy and location of muscle atrophy were assessed.
In serum , the expected increase of the water-soluble vitamins folate and vitamin B12 was observed with a concomitant decrease in homocysteine.
In session-1 , single trials covered a broad range of force-moment combinations.
In session-2 , four force-moment combinations were used with multiple trials at each.
In several cases , this resulted in a significant increase in the intracuff pressure.
In several cellular systems , ARF6 was shown to regulate actin dynamics in coordination with Rac1 , a Rho small GTPase.
In several elderly patients ( > 65 yr ) , we failed to locate the USCOM signal.
In several kindreds , mutations in the insulator led to impaired ankyrin expression and congenital hemolytic anemia.
In several neurodegenerative and metabolic diseases the dynamic balance of fission and fusion is disturbed.
In several species caloric restriction ( CR ) extends life span.
In severe AR , rheumatic fever was the most common etiology in patients below @number@ in those above @number@ etiology was mostly degenerative.
In severe cases , alarm systems comprising of a fire alarm and indicator of doorbell and telephone ringing may be necessary.
In severe cases , a surgical treatment should be considered.
In severe primary MR , mitral valve prolapse was the most common cause.
In sex-specific analyses no significant association with total cancer incidence was observed among men or women.
In sex-stratified analyses , the association between higher PiB-PET SUVR across all ROIs and measures of gait was only present among women.
In sheer number , the tally of genes linked to seizures will likely match that of cancer and exceed it in biological diversity.
In short , our study , employing ethnolinguistic vitality theory to analyze television advertisements , demonstrates how East Asian societies greatly marginalize older people.
In short , the price of more optimal physiological functioning during youth is a lower threshold for system failure in old age.
In Shunyi district , emmetropia was the most prevalent category over the ages 11-14.
Inside cells the glycerolphospholipids can be transferred to various intracellular membranes by lipid globules , liposomes , membrane-membrane contact or by lipid carrier transfer.
\ "Inside every old person is a young person wondering what happened. \ "
Insight in the predictors of disability is needed to target preventive strategies for people at increased risk.
Insight into remaining modifying factors is needed to assist and optimise fall prevention programmes.
Insight into the molecular mechanism of complex diseases is an important topic in the current bio-medical research.
Insights are often productive outcomes of human thinking.
Insights from biogerontology may be instrumental for developing new therapies for cancer.
Insights from these studies provide a paradigm for the function of miRNAs in facilitating cellular transitions during differentiation.
Insights gained by Granger connectivity analysis inform us about the causal binding of individual regions activated during religious belief processing.
Insights into associated determinants are essential to prevent sedentary behavior and limit health risks.
Insights into genetic origin of diseases and related traits could substantially impact strategies for improving human health.
Insights into RA function in the limb serve as a paradigm for understanding how RA regulates other developmental processes.
Insights into stem cell biology have identified the repair potential of stem cells.
In silico analysis indicates that rs490460 may be a potential splicing site , which affects protein structure.
In silico analysis predicted structural changes in the N-terminus of CAPZα1 , which may interfere with CAPZα : CAPZβ dimerization.
In silico modeling predicted that ( @number@ ) F-PBR111 would have a moderate to high specific-to-nonspecific ratio in the normal human brain.
In silico predictions of functional effects demonstrated a good correlation.
In silico studies play a major role in finding non-evident patterns of gene expression and gene network connectivity.
In silico , the C allele of LSP1-rs3817198 was predicted to increase expression of the tumor suppressor cyclin-dependent kinase inhibitor 1C ( CDKN1C ) .
In similar analyses , only walking was associated with bradykinesia and sway with tremor.
In SIPS , Aurora-B signaling is deprioritized , and the synthetic branches of cholesterol metabolism are upregulated , rather than downregulated.
In SIRT1-depleted cells , the acetylation levels of these regions were already higher than those in control cells in the pre-senescent stage.
In Situ Activation of Penile Progenitor Cells With Low-Intensity Extracorporeal Shockwave Therapy.
In situations of disease or in aging , it has proven to be more problematic.
In situations of longer term steady states , it serves a purpose.
In skeletal muscle and tendon the extracellular matrix confers important tensile properties and is crucially important for tissue regeneration after injury.
In skeletal muscle from men with mitochondrial haplogroup H , an increased intrinsic mitochondrial function is present.
In skeletal muscle of experimental animals , prolonged increase in O-GlcNAcylation associates with age and muscle atrophy.
In skeletal muscle the most abundant are Plin2 and Plin5.
In SKEW myofibrillar FSR remained lower than EB ( P = @number@ ) and lower than BAL ( P = @number@ ) .
In skin areas regularly exposed to sun , UV-damage is superimposed to tissue degeneration resulting from chronological aging.
In skin , the relationship between intrinsic changes and keratinocyte function is not clearly understood.
In Slavic folklore , Koschei the Immortal was bony , thin and lean.
In Slow , Elderly exhibited larger peak center-of-pressure ( COP ) displacement ( @percent@ ; P < @number@ ) during anterior perturbations.
In small arteries , ageing shows a eutrophic vascular remodeling and a reduced nitric oxide availability.
In smn-1 mutants we detected a reduced expression of U1 and U5 snRNAs and an increased expression of U2 , U4 and U6 snRNAs.
In smokers , greater pack-years were associated with smaller volumes of the total hippocampus , presubiculum , and subiculum.
In SNAC-K , @percent@ had ≥2 of these @number@ disease categories , @percent@ had ≥3 , and @percent@ had ≥4.
In so doing , all medicine is questioned.
In so doing , we provide a concise mechanistic discussion of some of the major tissue-specific roles of estrogens signaling through ERα.
Insoluble Aβ42 increased progressively with age.
Insoluble Aβ and 4-hydroxynonenal ( 4-HNE ) levels tended to be reduced in SAMP8 mice-fed the rice Aβ vaccine.
In somatic cells , it is well documented that p53 is rapidly activated upon DNA damage to arrest the cell cycle and induce apoptosis.
In some analysis study groups were chosen depending on sex.
In some areas , however , dengue fever has not emerged despite established Ae. aegypti populations.
In some but not all studies , lower levels of T predict increased incidence of cardiovascular events and mortality.
In some cases elastosis was so severe that it had affected the subcutaneous cellular tissue or venous or arteriolar walls.
In some cases , measures of event segmentation discriminated between those older adults with better and worse memory.
In some cases , micromanipulation is combined with the comet assay , a technique , which allows a direct view on DNA damages.
In some cases , only a long fibrous tract surrounded by a moderate mononucleate infiltrate was observed.
In some cases , pain circuitry is permanently changed , which may be a potential mechanism for sustained joint pain.
In some cases the response to low level environmental insults may not be obvious until adult or old age.
In some cases , these values depend on the gender and age as well.
In some cognitive abilities individual differences were evident in the relation of prior test experience and the magnitude of longitudinal change.
In some contexts , they delay the onset of age-related diseases and promote a healthy lifespan.
In some instances AD mitochondrial and bioenergetic changes are reminiscent of those observed with advancing age but are greater in magnitude.
In some instances , this mobilization benefits the organism , but in others it can be detrimental.
In some instances , VS women are worse than NVS women , reinforcing the need for novel adjunctive therapies to attenuate cognitive problems.
In some locations the risk of disease was @number@ times greater than the relative risk for the state.
In some networks , such as the default-mode network , males and females both showed decreases in connectivity with age , albeit at different rates.
In some patients , multiple timed behaviors occupy a considerable part of the patient's daily life.
In some patients , skin biopsy followed by histologic examination was performed.
In some persons very high levels of anti-ox LDL were stated , most frequently in the oldest persons , particularly in men.
In some populations , elevated plasma levels of tPA have been associated with myocardial infarction and other cardiovascular diseases.
In some regions ( PFC , VC , Cd , and Pt ) age-related differences in iron and volume followed similar patterns.
In some reports elderly patients don't seem to bring greater toxicity than younger.
In some settings , the improvement may be substantial.
In some subjects ( @percent@ ) , language comprehension and language production were lateralized to opposite hemispheres.
In some subjects , post-treatment edema was detected and resolved within @number@ h.
In some , there is overwhelming evidence that complement self-attack causes the disease.
Insomnia disorder is associated with both subjective and objective daytime impairments.
Insomnia , in particular , may occur in 60%-80% of depressed patients.
Insomnia interventions may improve functioning and quality of life among elders.
Insomnia is a common problem among older adults.
Insomnia is a serious worldwide health threat , affecting nearly one third of the general population.
Insomnia severity was associated with increased stress experience affecting serum BDNF levels.
Insomnia symptoms were prevalent but significantly decreased across the four waves ( ranging from @percent@ to @percent@ ) .
In South Africa , this may have been due to the exceptionally high prevalence of class III obesity.
In Southern / Eastern Europe , frailty index scores did not differ between groups ( p = 0.2 ) .
In Spain , as showing several studies , we are far from optimal control of CVRF , especially in secondary prevention of stroke.
In Spain , cerebrovascular disease ( CVD ) is a very common cause of morbidity and hospitalization.
In Spain , elder women are the largest group in need of long-term care.
In Spain , these experiences are scarce.
Inspiratory muscle training is emerging as a possible intervention to attenuate the decline of respiratory muscles in the elderly.
Inspired by the Nature , scientists have designed metal-based mimics of the superoxide dismutase.
In spite of advances in diagnostic imaging techniques , the incidence of septic arthritis and spondylitis appears to have been increased.
In spite of a greater intensity of treatment in most patients with CKD , BP control was similar to patients without CKD.
In spite of continuing study on the pathophysiology of disease , there remain no medical therapies to prevent the progression of CAVD.
In spite of intensive study , there is still controversy about the free radical or oxidative stress theory of aging , particularly in mammals.
In spite of its prevalence , the etiology of the disease is still poorly understood , and effective therapy is all but unavailable.
In spite of knowledge of these problems for a number of years many reserves are still available for the care of critical patients.
In spite of many interesting medical and surgical procedures , treating this area is sometimes difficult and results are not always up to our expectations.
In spite of such thematic diversity , several common threads are clear.
In spite of the basic role of noncoding RNAs in the regulation of gene expression , few studies have analyzed their role in human oocytes.
In spite of the consistent benefits for HIV-1 infected patients undergoing antiretroviral therapy , a complete immune reconstitution is usually not achieved.
In spite of the pivotal role of p53 during aging process , the knowledge of miR-194's contribution to cellular senescence is limited.
In spite of the potential benefits , some concerns have been raised.
In spite of the significant advances in conventional therapeutic approaches to CRC , most patients ultimately die of their disease.
In spite of this , older adults experience less negative affect than their younger counterparts.
In SPRINTT , the concept of physical frailty is translated with a Short Physical Performance Battery score of ≥3 and ≤9.
INSR is a direct target of CHIP , which triggers receptor monoubiquitylation and endocytic-lysosomal turnover to promote longevity.
In Srpski arhivza celokupno lekarstvo , there was registered only one article on the topic of the elderly , and @number@ on children.
Instability in the M / L direction has been reported to be closely related with the risk of falling in the elderly.
In stably transfected HEK-293 cells , GPR40 receptors underwent rapid agonist-induced internalization and constitutive ligand-independent internalization.
In stage @number@ meta-analysis , the significant association at UMOD was replicated.
In stage @number@ @number@ phosSNPs were meta-analyzed in @number@ individuals of various ancestries.
In stage @number@ @number@ SNPs were genotyped and tested for association in an independent set of @number@ Alzheimer's disease cases and @number@ controls.
In stage @number@ of the study , the Mini-Mental State Examination and the Montreal Cognitive Assessment were administered for screening purposes.
In stage @number@ the subjects who screened positive were further examined by neurologists.
In stage @number@ we genotyped @number@ samples using a whole-exome microarray.
In stage @number@ we intervened based on drawbacks discovered in stage @number@ implementing a dementia initiative program.
In stage @number@ we reinvestigated the outpatients to determine the effects of intervention.
Instances of Alzheimer's disease and other forms of dementia are becoming ever more frequent.
Instantaneous heart rate ( HR ) was recorded at 5-s intervals during representative 8-h shifts in @number@ merchant seamen.
Instead a closing / opening osteotomy may be preferable , but will require an additional anterior column support.
Instead , age-related spatial modifications occur in various regions of the craniofacial skeleton.
Instead , aging is a continuation of developmental growth , driven by genetic pathways such as mTOR.
Instead an increase in S100-IR was observed in senescent mice.
Instead an interactive tool was built to visualize the regression model in an accessible way for CFR practitioners as well as anatomists.
Instead a statistical approach was used on a large volume of fibrils in shorter image stacks.
Instead , BBB impairment may be associated with diabetes and brain microvascular damage.
Instead , children with better cognitive functioning are selecting healthier lives.
Instead , complex multi-factorial diseases require multi-pathway understanding and multi-targeting approaches which will often result in compound combinations.
Instead , computational modeling of the data indicated that older adults utilized fewer conceptual clusters of items in memory than did young adults.
Instead , conventional risk factors were found stronger predictors , most evidently education differentials were associated with CVD mortality.
Instead , diffuse increases in cellularity were present in HIV + individuals.
Instead , dread-sensitive choices were associated with higher conscientiousness.
Instead , employability is a characteristic of the individual alone.
Instead , here it is proposed that telomere length is primarily limited by energetic constraints.
Instead , hypoxemia results from ventilation-perfusion mismatch caused by closure of dependent airways at FRC.
Instead , immature and mature filamentous NIs were found only in the NIHID cases.
Instead , in apoE-KO mice FC deficits were mirrored by strongly reduced brain perfusion since adulthood.
Instead , in elderly patients , there are numerous physiological conditions that determine a bone metabolism alteration.
Instead , in monopodalic conditions , we found a significant reduction in the ESA of both feet with EO and EC.
Instead , in this paper we look at the actual mortality experienced by cohorts in a population , using cohort life tables.
Instead , it appears that caregivers relied on context in making the pain determinations.
Instead , it combines all age-related diseases and their preclinical forms , in addition to other pathological changes.
Instead , it was mediated by secreted NAMPT through its ability to activate the TGFβ signaling pathway via increased TGFβ1 production.
Instead , low WC is associated with an increased risk of developing ADL disability in nonagenarian women.
Instead , medical advances have actually facilitated such studies , by making it possible for children with life-threatening infections to survive.
Instead , neurodegeneration in hTDP-43 and hTDP-43-ΔNLS-expressing neurons was accompanied by a dramatic downregulation of the endogenous mouse TDP-43.
Instead , nutrient restriction was associated with reduced activity of the mTOR / S6 Kinase cascade.
Instead of being randomly dispersed in agarose in the traditional assay , cells are captured into an agarose microwell array by gravity.
Instead our data favor a late developing feedback or top-down cognitive process to explain the origin of facilitation.
Instead , p53 and p73 were fully responsible for apoptosis. p53 and p73 were also required for differentiation-induced apoptosis in mouse ESCs.
Instead , participants placed their survival in retirement \ "in God's hands. \ "
Instead , populations were predominantly mildly hyperopic or substantial amounts of myopia appeared in them.
Instead , reduction of gray matter density in ventrolateral prefrontal cortex correlates tightly with irrational behavior.
Instead , Runx family genes employ multiple spatiotemporal mechanisms in regulating individual tissue stem cell populations.
Instead , self-efficacy influenced self-care adherence.
Instead , Serbia is forced to start reforms to provide a more efficient health system.
Instead the effects of atDCS were state-dependent ( i.e. related to task performance at baseline ) .
Instead , the hypermetabolism may reflect a neuronal compensatory mechanism.
Instead , the older subjects showed a P3b , reflecting controlled processing of information.
Instead , these cohort members had lower IQ scores since childhood.
Instead , these results indicate that oral feeding is better regarding some nutritional biochemical parameters.
Instead , they provoke interpretation within the reader as witness and expand the ways in which research on aging and physical activity has been represented.
Instead they remain wrinkled and rigid while their non-polymerised counterparts resume their spherical floppy shapes.
Instead , tissue size , torque and ground reaction force have been used as proxy markers of intrinsic muscle force.
Instead , TRF2 binds and transactivates the promoter of the angiogenic tyrosine kinase platelet-derived growth factor receptor β ( PDGFRβ ) .
Instead , trial failures may be because of failure to significantly reduce load of toxic Aβ oligomers.
Instead , we found that Treg from aged mice are more resistant to apoptosis than Treg from young mice.
Instead , white matter in these regions appears to remain vulnerable to normal aging processes through the 10th decade of life.
InSTEP is a feasible model for addressing fall risk reduction in community-dwelling older adults.
Instituting measures to rapidly recognize this population in a crowd during an evacuation will reduce their risk.
Institutionalization further aggravates cognitive decline , probably due to the impoverished environment of nursing homes.
Institutionalization is generally a consequence of functional decline driven by physical limitations , cognitive impairments , and / or loss of social supports.
Institutionalization per se showed a strong effect on loneliness.
Institutionalization was independently associated with polypharmacy near the end of life ( odds ratio @number@ @percent@ confidence interval @number@.42-2.39 ) .
Institutionalization was strongly associated with AED use ( OR ( adjusted ) = @number@ @percent@ CI @number@.86-4.10 ) .
In stratified analyses , moreover , subjects with low personal income tended to have higher aging scores across different anthropometric groups.
In stratified analyses , these associations generally did not vary with health status.
In striking contrast , old participants generated a P3b to target letters with no reliable differences between conditions.
Instructing healthcare providers to recommend vaccine uptake is an important piece of this puzzle.
Instruction on how to use e-cigarettes was on @percent@ of the websites.
Instructors may evaluate the functional ability of their attendees through BBS to easily obtain more information and better plan ballroom dance classes.
Instrumental Activities of Daily Living score and residence were unrelated to Apo E ε4 or ε2.
Instrumental reminiscence is based on recalling times one coped with stressful circumstances , and analyzing what it took to adapt in those situations.
Instrumental variable analysis failed to show associations between sPLA2 enzyme activity and MVE.
Instrument domains correspond to those of the SF-12.
INSTRUMENT : Health-related quality of life was evaluated using the SF36v2 survey instrument.
Instrument language was developed a priori to pertain to non-demented functionally independent older adults.
Instruments included the Neurobehavioral Rating Scale , the Apathy Evaluation Scale , and the mini mental state exam.
Instruments predicting morale were then tested against PGC domains.
In studies conducted on acute stroke patients , risk factors and time course were not evaluated.
In studies of immune aging , naive T cells frequently take center stage.
In studies that provided EPA and DHA to adults with mild cognitive impairment or age-related cognitive impairment the data seem to be positive.
In Study @number@ all age groups demonstrated RIF in conditions where output interference was promoted.
In study @number@ healthy elderly persons ( n = 16 ) and healthy young persons ( n = 16 ) volunteered.
In Study @number@ lung function , respiratory resistance and eNO level were measured in age- and height-limited groups.
In Study @number@ ( N = @number@ ) , reward and threat perceptions were experimentally manipulated followed by measurement of investment model constructs.
In Study @number@ @number@ older people completed the scales , and data were submitted to a principal components analysis.
In Study @number@ participants rated the positivity of their own positive , negative and neutral memories as well as those of a same-aged peer.
In Study @number@ participants read mock news articles reporting evidence in favor of either the entity or incremental theory.
In Study @number@ participants with AD , younger , and older adults were tested on an adaptation of the ACE Paradigm.
In Study @number@ state self-esteem was experimentally manipulated.
In Study @number@ the authors found that the vast majority of participants are willing to consider the use of a smart nightstand.
In Study @number@ the choice task involved real outcomes and the sample consisted of younger and older adults.
In Study @number@ the choice task was hypothetical and the sample was an adult life span sample.
In Study @number@ the new scales were administered to @number@ older people.
In Study @number@ the same measures and a new scale to measure perceived respect from younger people were administered in a longitudinal survey.
In Study @number@ the same paradigm was modified to include an arm movement that participants had to perform prior to sentence exposure on screen.
In Study @number@ volunteers , aged 50-90 years , participated in a two-phased task.
In Study @number@ we administer this measure to @number@ older and @number@ younger adults.
In Study @number@ we found that older adults ' broader retrieval initiation generalized when they were given twice the encoding time compared with Study @number@
In Study @number@ we replicated these age differences in a dual-list paradigm with semantically associated lists.
In subanalyses stratified for selected covariates , ΔWC point estimates were consistently higher in DS users.
In subgroup analyses , results did not change according to age group at baseline ( 70-76 or > 76 years ) or functional status.
In subgroup analyses , the inverse association between leptin and AMD was significant in women , Indian ethnicity , and ex-smokers.
In subgroup analysis , the Juvederm™ family achieved the best efficacy , while their adverse event incidence was significantly higher than other HA products.
In subgroups , we analyzed TL in isolated small and large adipocytes and SVF cells.
In subject group significantly more patients are on the verge of poverty.
In subjects over @number@ years old , object categorization was greatly slowed down when compared to young and middle-aged subjects.
In subjects with hypertension @percent@ , @percent@ and @percent@ also had metabolic syndrome.
In subjects with long-term SCI , sclerostin levels were positively associated with lower extremity bone density and bone mineral content.
In subjects without the APOE ε4 allele , CAA severity was associated with lower cognition proximal to death , factoring in other pathologies.
In such a milieu , heart and vessels develop a functional impairment leading to atherosclerosis , ischemia , heart insufficiency and failure.
In such areas , mosquito control programmes should be conducted only after the vaccination programme with a high coverage has been initiated.
In such a study , standard operating procedures ( SOPs ) are an essential task , which are binding for all MARK-AGE Beneficiaries.
In such cases , a cardiology colleague interested in QTc interval issues and TdP should be asked to review the ECG.
In such cases , an extension of public services could give rise to a better outcome from the overall health investment.
In such cases , use of other therapeutic alternatives should be considered.
In such cells , mitochondria are organelles critical for bioenergetic supply , whose turnover is mediated by an autophagic-lysosomal pathway.
In such meetings , they received the applications and they were encouraged to use it.
In such open environments , their body movements become complicated by various external factors and may follow unstable and nonuniform patterns.
In such patients , conservative therapy should be taken into consideration.
In such patients , intensifying pancreatic enzyme supplementation may be useful.
In such patients , the difficulties to treat pain and to clearly identify its causes may lead to treatment discontinuation.
In such scenario , focal prostate cancer therapy currently relies on the index lesion concept as the dominant lesion that drives the disease natural history.
In such scenarios , search performance is likely not impaired beyond what is found with distracters ( visual clutter ) in the environment.
Insufficient assistance at mealtimes can contribute to this and therefore trained volunteer mealtime assistants may be of benefit.
Insufficient autophagy may be an underlying mechanism of accelerated epithelial cell senescence and myofibroblast differentiation in IPF.
Insufficient evidence is available to test the efficacy of reduction behavioural support in promoting long-term cessation among this population.
Insufficient levels of iodide can lead to increased expression or activity of several pathways , including vascular endothelial growth factor ( VEGF ) .
Insufficient pain education and inaccurate beliefs about the nature of pain and aging have been identified as possible contributors.
Insufficient proof of causal mechanisms currently precludes the recommendation of coffee consumption as a public health measure.
Insufficient protective autophagy could cause damaged cellular components to accumulate over many years until they affect normal function in the cell.
Insufficient time and emphasis on the relational dimensions of care made it difficult to \ "treat residents as human beings. \ "
Insufficient time was a commonly endorsed barrier to enrolling in other Center-approved studies , particularly among younger participants.
Insular activation was selectively reported during processing of disgusted and angry faces.
Insulin also increases arteriolar vasomotion.
Insulin and estradiol were not correlated with cortisol or androgens.
Insulin and metformin were used by @number@ and @number@ participants , respectively.
Insulin , a vasoactive modulator regulating peripheral and cerebral blood flow , has been consistently linked to aging and longevity.
Insulin cascade protects against mitochondrial damage caused by Aβ treatment , restoring the mitochondrial membrane potential.
Insulin-glucose dynamics were determined by an intravenous glucose tolerance test , and vitamin D metabolites were measured.
Insulin / IGF-1 signaling emerged one common pathway targeted by these miRNAs.
Insulin / IGF-1 signalling regulates ageing in worms , flies and mammals.
Insulin / IGF-like signaling ( IIS ) and nutrient sensing are among the most potent regulators of health status and aging.
Insulin increased memory performance in young rats , but not in aged rats.
Insulin insufficiency and insulin resistance may contribute disproportionately to abnormal glucose tolerance in people of different age.
Insulin / insulin-like growth factor-1 ( IGF-1 ) signalling ( IIS ) pathway was the first nutrient sensing pathway discovered to affect the aging process.
Insulin is stored within the secretory granules of pancreatic β-cells , and impairment of its release is the hallmark of type @number@ diabetes.
Insulin itself positively regulates β-cell proliferation in an autocrine manner through the insulin receptor ( IR ) signaling pathway.
Insulin-like growth factor-I ( IGF-I ) is known to be an anabolic factor in tendon , and the systemic levels are reduced with aging.
Insulin-like growth factor @number@ ( IGF-1 ) has been reported to attenuate Aβ toxicity in neuronal cells.
Insulin-like growth factors ( IGFs ) are important modulators of organismal life-span all along phylogeny.
Insulin-like growth factors were discovered more than @number@ years ago as mediators of growth hormone that effect growth and differentiation of bone and skeletal muscle.
Insulin lispro may be considered a safe and efficacious therapeutic option for the management of T2DM in geriatric patients.
Insulin-mediated suppression of glucose production was modest prior to bed rest and was further reduced ( > 15% ± @percent@ ) by bed rest.
Insulin receptors are expressed in the brain and physiological roles for insulin in the CNS are starting to be delineated.
Insulin regulates glycogen synthase ( GS ) through incompletely defined pathways that activate the enzyme through dephosphorylation and , more potently , allosteric activation.
Insulin resistance and type @number@ diabetes are associated with cognitive decline and increased risk for Alzheimer's disease ( AD ) .
Insulin resistance based on fasting insulin levels and homeostasis model assessment of insulin resistance ( HOMA-IR ) was assessed in all groups.
Insulin resistance ( HOMA-IR ) and glomerular filtration rate ( GFR ) were similar between control smokers and COPD patients.
Insulin resistance , inflammation , microvascular disease , and a tendency to thrombosis are common in these patients.
Insulin resistance ( IR ) is a phenomenon related to inflammatory and oxidative stress.
Insulin resistance ( IR ) was associated with CI in the early cART era , when antiretroviral medications had greater mitochondrial and metabolic toxicity.
Insulin resistance is a risk factor for various age-related diseases.
Insulin resistance is characterised by impaired insulin-mediated glucose disposal in skeletal muscle.
Insulin resistance is present at the muscle mitochondrial level , and is not affected by reducing circulating NEFAs in type @number@ diabetes.
Insulin resistance may be multifaceted and conventional approaches to regard insulin resistance itself as a pathological condition may be reconsidered in this light.
Insulin resistance may further contribute to regional perfusion deficit in T2DM.
Insulin resistance occurs independently of age mostly due to unhealthy lifestyle on top of genetic predisposition.
Insulin resistance plays a key role in the development of type @number@ diabetes.
Insulin resistance predicts frailty , and DM accelerates muscle strength loss.
Insulin resistance-related general unwellness might be reflected by AMS values.
Insulin resistance was assessed by HOMA-IR , NAFLD by UltraSound Brigh-Liver-Score ( BLS ) .
Insulin resistance was associated with shorter time to FMP independent of the biomarkers.
Insulin resistance was considered to be present with a homeostatic model assessment index > 2.8.
Insulin resistance was highly correlated , however , with increases in BMI between birth and @number@ years of age.
Insulin resistance was measured with homeostasis model assessment ( HOMA-IR ) .
Insulin resistance was modeled as fasting insulin , HOMA and QUICKI.
Insulin secretion and cell viability were determined by RIA and MTS assays , respectively.
Insulin sensitivity ( clamp ) and intramyocellular triacylglycerol content did not change with the intervention in either group.
Insulin sensitivity index increased in the EXE group compared with the CON group ( P < @number@ ) .
Insulin sensitivity ( M of E-clamp ) increased progressively at 3-12 months as fat mass decreased.
Insulin sensitivity was determined with the clamp technique.
Insulin sensitivity was estimated by Matsuda's insulin sensitivity index ( Matsuda ISI ) , and insulin secretion was measured by the insulinogenic index.
Insulin sensitivity was increased after caveolin gene transfer as determined by decreased blood glucose levels in response to insulin injection and fasting blood glucose levels.
Insulin should be used with caution and with careful measures to avoid hypoglycemia.
Insulin showed a similar association pattern , although the associations were less strong than for leptin.
Insulin signaling plays an important role in the regulation of myocardial fuel metabolism , mitochondrial function and cellular growth.
Insulin signaling regulates various aspects of physiology , such as glucose homeostasis and aging , and is a key determinant of female reproduction in metazoans.
Insulin-stimulated CENP-A / PLK1 protein expression is blunted in islets from patients with type @number@ diabetes.
Insulin-stimulated glucose disposal ( Rd ) and substrate oxidation were assessed by euglycemic hyperinsulinemic clamps combined with indirect calorimetry.
Insulin therapy in older adults is complicated by psychosocial and physiological changes of aging.
Insulin therapy is the preferred method for achieving glycemic control in hospitalized patients with T2D and fractures.
Insulin use had a greater association with a more negative quality of life compared with other antidiabetic agents.
In sum , cortisol increased the deactivation of several brain areas , although the location of the affected areas in the brain was age-dependent.
In sum , during middle childhood , putative measures of UWM , inhibition , and shifting may rely on similar underlying cognitive processes.
In sum , laypeople's conceptions of wisdom vary along similar lines as those of wisdom psychologists.
In summary , among individuals with equivalent diet quality , the magnitude and characteristics of the diet-cognition relationship depended on their socioeconomic circumstances.
In summary , among those who survive an episode of pneumonia , recurrence is not uncommon , particularly in the elderly.
In summary , a small but significant improvement in MOF and HF risk assessment was found by using lumbar spine TBS to adjust FRAX probability.
In summary , atherogenic indices were directly linked to faster increase in depressive symptoms among women only.
In summary , BBB permeability is increased in major dementia disorders but does not relate to amyloid pathology or APOE genotype.
In summary both older and younger adults recruit highly organized activation patterns in response to changing external moments.
In summary , both water- and land-based activities were beneficial in maintaining strength and in improving lower-body flexibility.
In summary , c-ABL appears to promote senescence or inhibit apoptosis , depending on the extent of DNA damage.
In summary , CAC was independently associated with low femoral BMD in HIV-infected patients.
In summary , Canadians are at a healthcare crossroads.
In summary , central pressures and amplification were sensitive indicators of cognitive aging , predicting aspects of cognitive performance not predicted by brachial blood pressure.
In summary , distal skin temperature pattern can be used as a robust variable to discern between different ages throughout the life.
In summary , distinct personality traits were associated with stable individual differences in GM volumes.
In summary , endurance runners obtained their best performance in the marathon at @number@ years in men and @number@ in women.
In summary , ERα differentially interacts with HDACs @number@ and @number@ to regulate transcriptional activity.
In summary , hypomethylation of COL15A1 occurs during SMC proliferation and the consequent increased gene expression may impact SMC phenotype and atherosclerosis formation.
In summary , incidental VTE is a relative common finding in patients with solid tumours , especially in the first months of chemotherapy.
In summary , in diabetic patients , concurrent masked hypertension increases the odds of having CVD.
In summary , inflammation is a critical component in the maintenance of energy balance in the body.
In summary , inherited catalase deficiency is associated with clinical features , pathologic laboratory test results , age and oxidative stress related disorders.
In summary , long time cancer survivors represent a subgroup of patients at great risk of developing CVD in any form.
In summary , males and low-BMI individuals exhibited more concentrated loading over the greater trochanter.
In summary , MCI patients present difficulties in advantageous decision making that resemble those reported for patients with mild dementia.
In summary , novel detergent-insoluble proteins , with evidence of proteinaceous deposits , were found in amygdalae of elderly , cognitively impaired subjects.
In summary , older adults have larger IMCL droplets , fewer mitochondria , and a lower proportion of IMCL in contact with mitochondria.
In summary , our data suggested that chronic cigarette smoking could induce synaptic changes and other neuropathological alterations.
In summary , our data suggests that LiCl reduces inflammation in aged and young DCs via different mechanisms.
In summary , our findings establish the pathway by which this tumor suppressor protein is delivered from extracellular space to the nucleus.
In summary , our findings provided novel aspects of OPRK1 and OPRM1 methylation in Xinjiang Uygur and Han populations.
In summary , our findings suggest that βTrCP regulates turnover of BMI1 and its function relevant to oncogenesis , cellular senescence and aging.
In summary , our results highlight the significance of Wnt signalling in male germ cells.
In summary , our results indicate that FXR and TGR5 may play an important role in modulation of age-related kidney disease.
In summary , our results suggest that Sirt1 suppresses acute lung inflammation during sepsis by controlling inflammasome activation pathway.
In summary , our results suggest that the placental extract in the food supplement might contribute to rejuvenation and antiaging.
In summary , our study demonstrated that Wnt / β-catenin signaling may play a vital role in the age-dependent neural differentiation of DSCs.
In summary , our study found VDR gene expression increases following treatment with @number@ , 25OH2D3 in human myoblasts.
In summary , our study identifies a disease mechanism in BCC involving mutations in regulatory noncoding elements and uncovers the tumor-suppressor properties of ACTRT1.
In summary , our study indicated that an increment of MetS component is strongly associated with shorter LTL , especially in the female population.
In summary , oxylipins are an important group of molecules amenable to dietary manipulation to target cardiovascular disease and age-related degeneration.
In summary , P2X7R stimulation raises lysosomal pH and impedes lysosomal function , suggesting a possible role for overstimulation in diseases of accumulation.
In summary , patients affected by highly proliferative tumors with decreased p400 expression exhibit a poor prognosis by multiple Cox regression.
In summary , people are the most vulnerable to temperature variations in the early morning around @time@ and the night time around @time@ .
In summary , @percent@ patients work on a daily basis.
In summary , plasma Aβ can help predict cognitive function in adults with DS independently of the presence or absence of dementia.
In summary , PLK1 inhibits MTORC1 and thereby positively contributes to autophagy.
In summary , positive associations between age and levels of oxidatively damaged DNA appeared mediated by age-related increases in metabolic risk factors.
In summary , septal fat content is representative of mean fat percentage.
In summary , Sirt2 is critical in human glioma via NF-κB-miR-21 pathway and Sirt2 activator may serve as candidate drug for glioma therapy.
In summary , T cell repertoire analysis in older individuals may be useful as one of the predictors of protection after vaccination.
In summary , telomere length undergoes shortening in early stage gastric carcinoma and lengthening in advanced gastric carcinoma.
In summary , the ACE I / D polymorphism is not significantly associated with extreme longevity in the Spanish population.
In summary , the ACEt R package offers a useful tool for the exploration of age-dependent heritability and model comparison in twin studies.
In summary , the body sodium ( Na + ) balance is regulated by a complex interplay of environmental and individual factors.
In summary , there is marked hemispheric asymmetry in auditory cortical metabolites following pure tone stimulation in young , but not older adults.
In summary , the role of melatonin in the GI tract is coming of age.
In summary , these data suggest that human rePON1 protects against sarin and soman exposure in guinea pigs.
In summary , these findings add to the general notion that there is a decline in the ability to mentally represent action with advanced age.
In summary , these results highlight the need to calibrate arterial spin-labeling sequences.
In summary , these results suggest a novel model wherein SNP-modulated RNA splicing modulates CD33 function and , thereby , AD risk.
In summary , these results suggested that cardiovascular and cortical reactivity to stress tasks are a function of age.
In summary , this analysis showed apparent differences in stratified activity patterns even when traditional regression analyses on volumetric accelerometer data yielded null results.
In summary , urea is a re-emerging Dark Force in CKD pathophysiology.
In summary , we could demonstrate particular changes in the peripheral blood B cell compartment during ontogeny.
In summary , we demonstrate that brain microstructural abnormalities are associated with abnormal glucose metabolism in the caudate and hippocampus of HIV-infected individuals.
In summary , we describe multiple defects in inflammatory pathways in which LRRK2 appears to be critically involved.
In summary , we developed a comprehensive social network typology for older Korean adults.
In summary , we document a high incidence of ES after syngeneic HSCT.
In summary , we found that movement variability is partially a form of exploration driven by the recent history of rewards.
In summary , we observed consistent inverse associations between six circulating biomarkers and objective measures of physical performance.
In summary , we provide novel evidence that products of age-related inflammation modulate neutrophil phenotype in vivo.
In summary , we provide strong evidence that BA plateaus @number@ to @number@ years earlier than BMC.
In summary , we used molecular modeling to improve the potency of CYGAK , while creating CYGAK-oleic acid heterodimers to improve efficacy in cells.
In summary , we validated known and identified additional determinants for wrinkling.
In summary , women's gait is characterized by greater ankle ROM than men while men tend to have greater hip ROM than women.
In summary , working memory emerges as a primary impairment in children with ADHD who have no comorbid disorders.
In summary , α1-takusan protects synapses from Aβ-induced insult via interaction with PSD-95 and tau.
In sum , motivational valence and salience effects differentially modulated the temporal stages of context processing in younger and older adults.
In sum , our findings link let-7a abundance to the expression of p66Shc , which in turn controls the replicative lifespan of HDFs.
In sum , our findings suggest that fluency affects person-related source memory via within-modality repetition priming in both younger and older adults.
In sum , our results identify PP as a pivotal modulator of somatostatin secretion.
In sum , our study provided novel insight into the relationship between connectivity and syntactic performance in young and older adults.
In sum , sex-diet , sex-gene and gene-diet interactions were detected in determining SUA.
In sum , the French national health insurance system has become less and less efficient over the years.
In sum , the present performance-based evidence speaks for multidirectional age differences in empathy.
In sum , the proposed ESM constitutes a promising framework to clarify intra-brain region to region transference mechanisms associated with aging and neurodegenerative disorders.
In sum , the selective expression of DPP4 on the surface of senescent cells enables their preferential elimination.
In sum , this set of ecologically valid stimuli provides a useful tool for scientists engaged in cognitive and neuroscience-based research.
In support , a growing number of studies are showing specific posttranscriptional regulation of miRNAs.
In support , a growing number of studies are showing specific posttranscriptional regulation of miRNAs.
In support of our hypothesis , MEAMs were more vivid than autobiographical memories evoked by faces.
In support of our hypothesis , we also observed that lower WM integrity was associated with poorer cognitive-motor performance.
In support of the hypothesis , none of these arm reactions was guided by concurrent visual fixation of the handrail.
In support of this finding , immunohistochemical analysis showed increased GGT1 expression in PC tissues compared with BPH tissues.
In support of this mechanism is the observation that rhodamine123 , the cationic probe targeting mitochondrial electron chain , also suppressed rpS6 phosphorylation.
In support of this , we have found decreased mitochondrial bioenergetics with increased age in Sprague-Dawley rats.
In survey-based health services research , investigators should not stratify by census-defined immigration status , but rather by cultural background.
In Switzerland , the MAPDAQ has been translated into a German Version ( MAPDAQ-G ) , but not yet tested for its validity and reliability.
In Sydney , a State Ageing Strategy developed a whole-of-government plan that has yet to be incorporated into budget processes.
In synaptic spines and in adipocytes , HCAR1 immunoreactivity is also located on subplasmalemmal vesicular organelles , suggesting trafficking to and from the plasma membrane.
In systemic lupus erythematosus , DHEA is steroid-sparing.
Int.
In T2DM , impairment of resting regional perfusion is closely related to worse cognitive and mobility performance.
Intact epidermal barrier function is crucial for survival and is associated with the presence of gradients of both calcium ion concentration and electric potential.
In Taiwan , daughters may have been more beneficial than sons in reducing mortality in recent years.
Intake of antioxidant products may help to retain bone-mass density.
Intake of cholesterol , glucose and sodium were positively associated with increasing medication use.
Intake of fat-soluble vitamins , B vitamins , carotenoids and minerals was lower in those with increasing number of medications.
Intake of methyl-donor micronutrients was not associated with DNA methylation.
Intake of pancreatic enzymes induced a slow increase in protein digestibility in CF until @percent@ of values obtained by healthy subjects.
Intake of vitamins and minerals from dietary supplements was estimated from interviews.
Intakes of energy and macronutrients carbohydrate , fat and protein declined significantly over the @number@ months.
Intakes of magnesium and vitamins A , C , and E were the most inadequate compared with Estimated Average Requirements.
Intakes of most nutrients were greater from the complementary feeding component of the diet.
Intakes of vitamins and minerals all declined with age and subjects had suboptimal intakes of folate , vitamin E and calcium at all time points.
Intangible costs were assessed using the 12-item Zarit burden interview ( ZBI ) tool and the financial cost dimension of the cost of care index.
In tauopathies , a neural microtubule-associated protein tau ( MAPT ) is abnormally aggregated and forms neurofibrillary tangle.
In tauopathy diseases , tau protein deposition in the posterior lobe is advanced compared to that in non-tauopathy diseases.
In Tcad-KO mice , binding of endogenous and exogenously administered Adipo to cardiovascular tissues was dramatically reduced.
In T-cells , autophagy has an essential role in modulating protein and organelle homeostasis and in the regulation of activation-induced responses.
In T cells from human cord blood and bovine calves , oenothein B was unable to induce IFNγ production.
Integral components of these pathways , Ras , B-Raf , PI3K , and PTEN are also activated / inactivated by mutations.
Integral to the framework is the concept of complexity of care.
Integratability of stimuli is therefore a new factor that reduces associative deficits in older adults , most likely by supporting encoding and retrieval mechanisms.
Integrated albunemia increases and accelerates with age in all populations , and predicts mortality and frailty but not chronic disease even after controlling for age.
Integrated assessment of SDB is necessary to characterize its effects on arterial stiffness.
Integrated demineralization was determined by cross-sectional microhardness at both margins of the restoration : enamel and dentin.
Integrated discriminant improvement analysis showed that the TYM-MCI added value to the conventional memory assessment.
Integrated intensities in digital electron micrographs were related directly to protein density , which is linearly related to RI for a given substance.
Integrated self-management interventions have been developed to address both general medical and psychiatric illnesses.
Integrating all dietary features into the total MeDi score explained less variance in cognitive functioning and brain volumes than its single dietary component meat intake.
Integrating the Carer Support Needs Assessment Tool in existing practice is fundamental to achieving better caregiver outcomes.
Integrating the salutogenesis in educational sciences further expands the concepts of HE and HL into healthy learning.
Integrating these sections , OCT can reconstruct three-dimensional tissue anatomy.
Integrating these three theories , we propose a model that explains RAEs through these various social agents.
Integrating the visualizations into a wellness framework helped reduce the complexity of raw smart home data.
Integration of Illumina 450k with appropriate ENCODE data may represent a fruitful approach to identify transcription factors with key roles in aging and disease.
Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies.
Integrative clustering of @number@ samples identified keratin-low squamous , keratin-high squamous and adenocarcinoma-rich subgroups.
Integrative relations facilitated older adults ' memory to a similar extent as semantic relations despite having few preexisting associations in memory.
Integrative relations occur when two dissimilar and unassociated words are linked together to form a coherent phrase ( e.g. , horse-doctor ) .
Integrin-associated protein ( IAP / CD47 ) has been implicated in macrophage-macrophage fusion.
Integrin mRNA levels were determined by real-time polymerase chain reaction studies.
Intellect at age @number@ was weakly associated with contemporaneous verbal fluency but had no significant effects on fluency at age @number@
Intellectual functioning remained stable.
Intelligence agencies frequently report that terrorist groups and rogue nations are seeking to obtain radiological or nuclear weapons of mass destruction.
Intelligence might be affected by age-associated network deterioration only if a certain threshold of structural degeneration is exceeded.
Intelligence Quotient ( IQ ) is regularly used in both education and employment as a measure of cognitive ability.
Intelligence quotient ( IQ ) was measured in childhood and adulthood.
Intelligent icons of normalized activity transition prevalence , a visual representation of time-series data , were examined among those who self-reported mobility difficulty.
Intelligibility of the distorted words was equated across age groups for each presentation level.
In telomerase-negative WRN-deficient cells , T-SCE-but not G-SCE-frequencies were significantly increased compared with controls.
Intense MMP-1 and MMP-9 expression was detected in malignant skin epithelial neoplasms as different clinicomorphological types of basal cell carcinoma.
Intense nuclear staining of DNA damage foci was observed in nuclei within the central endothelium of older donors.
Intensified efforts are required to improve lifestyle , awareness of the condition , and use of appropriate and well tolerated combination therapy.
Intensity , assessed using percentage of heart-rate reserve and the Borg scale , equaled intended intensity for both programs.
Intensity changes are consistent with possible altered myelination or glial function.
Intensity increased across repetitions plateauing earlier for the vasti than RF during CS.
Intensity of immunohistochemical staining to von Willebrand factor is enhanced during age.
Intensity of staining for AGEs was greater in the airways ( p = @number@ ) and alveolar walls ( p = @number@ ) in COPD.
Intensity of staining for RAGE was also significantly increased in alveolar walls ( p = @number@ ) but not the airways.
Intensity of staining to CD31 is not changed with age.
Intensity of these changes in the hemostatic system is enhanced in the presence of IGT.
Intensive BP control was associated with greater decline in TBV at @number@ months relative to standard therapy.
Intensive care unit ( ICU ) -acquired weakness is common and characterized by muscle loss , weakness , and paralysis.
Intensive treatment decelerated volume loss , particularly in regions adjacent to those cross-sectionally associated with diabetes duration.
Intensive treatment for very sick people will not decrease SES mortality differences.
Intensive volunteering was defined as service done on a 24-hr a day basis at a location away from home.
In ten studies , additional secondary ossification centers were identified in the inferior two-thirds of the glenoid.
Intent did not vary with race , but mean scores of the predictors of intent varied for African American and White women.
Intentionally , groups were matched by age , aerobic capacity and in addition the control and post-obese groups also by BMI.
Intentional weight loss was not associated with mortality.
Intentions and attitudes towards parenthood and awareness regarding female fertility were assessed using the Swedish Fertility Awareness Questionnaire.
Intentions to use these services were also low , at @percent@ ; however , this increased with level of familiarity.
Intention-to-treat analyses were performed from @date@ through @date@ .
Intention-to-treat analysis was in concordance with the complete cases analyses.
Intention-to-treat analysis will be used.
Intention-to-treat ( ITT ) and per-protocol ( PP ) analyses were carried out.
Intention-to-treat ORR was @percent@.
Intent-to-treat analysis using mixed-effects growth models of within-person change over time tested if caloric restriction slowed increase in measures of biological aging across follow-up.
Interacting with older adults is a daily practice for pharmacists.
Interaction among the group identified work modifications which empowered the farmers to make positive changes in their own work behavior.
Interaction analyses revealed that the effect of self-regulation on exercise capacity was stronger among women who chose to work on exercise.
Interaction analysis showed that depression significantly amplifies the association between TB and difficulties in self-care but not in other health domains.
Interaction analysis showed that obese individuals in high-income countries were more likely to have ADL limitations than those in low-income or middle-income countries.
Interaction between Aβ and Drp1 is reduced in DDQ-treated AD neurons.
Interaction between gene sets and survival and treatment response by breast cancer subtype was assessed in individual datasets and also in pooled datasets.
Interaction effects ( language × age ) were observed for AF.
Interaction effects of As , Cd and Pb on their respective bioaccessibility in co-contaminated soils were reported.
Interaction effects of coping and health on work ability were weak.
Interaction effects revealed that the SNR effect varies as a function of noise type and is most systematic for continuous noise.
Interaction estimates were meta-analysed using a fixed-effects model.
Interaction models describe the change of SES mortality differences with age or health , days in hospital being a proxy for the latter.
Interaction p27 with cyclin E-Cdk2 complex can have two consequences.
Interactions among environmental factors , multiple susceptibility genes and aging , contribute to AD.
Interactions between age and cytokines were further analyzed in multiple regressions.
Interactions between age , and PC's of opiate and inhaled intoxicant dose and duration of exposure were highly significant ( p < 0.01 ) .
Interactions between age , sex , and ancestry were also identified.
Interactions between APOE / FOXO3 , APOE / CRYL1 , and LPA / CRYL1 did not remain significant after multiple testing correction.
Interactions between cancer and type of insurance allowed testing for differential effects of a cancer diagnosis.
Interactions between dietary intake and genetic risk levels were assessed.
Interactions between environmental , therapeutic , and genetic factors are being explored.
Interactions between neighborhood and individual-level characteristics should be considered in research on mobility.
Interactions between neural and muscle cells that contain dysfunctional mitochondria exacerbate sarcopenia.
Interactions between PA and age on the BMI and HRQL relationship were assessed using general linear models and logistic regression.
Interactions between polypharmacy ( an average use of ≥5 prescription drugs daily ) and comorbidities or potentially inappropriate medications ( PIMs ) were tested.
Interactions between quality of life for group of elderly people and social-medical care contribution to it have been discussed.
Interactions between sex and age as independent variables were analyzed by two-way analysis of variances.
Interactions between the immune and endocrine systems are not well studied in marsupials and monotremes.
Interactions by self-rated health , living arrangement , and race were tested.
Interactions were checked to assess whether the factors associated with IR were different in those with and without CKD.
Interactions were tested by including the term \ "fall history change in BMD \ " in the models.
Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.
Interaction terms were also significant ( p < @number@ ) ( Dunnett-T3 ) .
Interaction terms were also significant ( p < @number@ ) ( Tukey's test ) .
Interaction was assessed using multiplicative interaction terms in multivariate-adjusted models.
Interaction was evaluated using a fixed effects meta-analysis of an efficient Empirical Bayes estimator , and permutation was used to account for multiple comparisons.
Interaction with an adaptor protein MOB is also important for LATS1 / 2 activation.
Interactive video dance games can increase activity in young persons but have not been designed for use with older adults.
Inter and intra division obstacles were discussed.
Inter- and intramuscular coordination strategies differed between YP and AP reflected in changes in CCF and peak EMG values.
Inter- and intraobserver final scores showed high agreement.
Inter- and intra-rater reliability was calculated using Cohen's kappa coefficient.
Interatrial conduction disturbances play a crucial role in the initiation of atrial fibrosis and in its associated complications.
Interbody fusion was completed using the XLIF technique with supplemental posterior instrumentation.
INTERcheck ( ® ) is a Computerized Prescription Support System ( CPSS ) developed in order to optimize drug prescription for elderly people with multimorbidity.
Intercoder reliability was moderately high for both percent agreement and Cronbach's kappa.
Intercommunication is marked between the level of social adaptation , quality of life and rate aging combatants.
Interconnectivity and feedback control are hallmarks of biological systems.
Intercytex provided financial support for this study.
Inter-day reliability was adequate for all muscles ( coefficient of variation < @percent@ ) , except for TP.
Interday %RSD was ≤7.13% , @percent@ , and @percent@.
Interdependent self-construal is identified to be an important moderator of this phenomenon.
Interdisciplinary and community-based efforts are needed to devise effective strategies to detect , treat , and prevent elder abuse in our increasingly diverse aging populations.
Interdisciplinary approaches combining genetics , molecular and cell biology , and laboratory animal science have revealed some of its potential molecular mechanisms.
Interdisciplinary methods from longitudinal observational studies should be leveraged to enable translational interventions to promote brain longevity.
Interdisciplinary research projects on ICT in ageing societies are needed and recommended.
Inter-discipline communication among neurology , dermatology and geriatrics / gerontology is required to tailor specific managements for elderly patients with pruritus and neurodegenerative diseases.
Interest in and interventions for photodamaged skin have dramatically increased over the last few years.
Interesting data was noticed that @number@ patients with more serious ARMD on one side of head had greater hearing loss on the same side.
Interesting differences were demonstrated between the Polish and Swedish populations.
Interesting issues on longevity and interventions on aging ( including caloric restriction ) and on aging brain are quoted.
Interestingly , activation of JNK signaling was also clearly present in lungs of SPC-TNF-α mice and patients with COPD.
Interestingly , acute irradiation of aged brain with a certain amount of radiation has also been reported to induce brain hormesis or neurogenesis.
Interestingly , adaptation of HDAC5-depleted cells to oxidative stress passes through reprogramming of metabolic pathways towards glucose and glutamine.
Interestingly , a decreased production of the pineal melatonin has been shown to deregulate the circadian rhythm machinery and increase cancer risk.
Interestingly , a gain of the identified markers accompanied by a transient gain of proliferation was observed following chemically induced pancreatitis.
Interestingly , AGE-induced p16 expression and premature senescence were successfully attenuated by ER stress inhibitor and ATF4 gene silencing.
Interestingly , age ≥ @number@ years is associated with MRSA VAP.
Interestingly , age-related decrease in NO production partially results from endothelial insensitivity to shear stress.
Interestingly , Ala carriers showed lower telomere shortening after @number@ years compared with the Pro / Pro genotype ( P = 0.031 ) .
Interestingly , a large number of differentially expressed proteins were found to be of platelet origin.
Interestingly , all components were found to be preserved after declining.
Interestingly , all these diseases are associated with defects in the maintenance of our genome.
Interestingly , alterations of A-type lamins lead to defects in DNA replication and repair as well as gene transcription and silencing.
Interestingly , although blind individuals showed on average the same fibroblast clock properties as sighted ones , their physiological periods were significantly longer.
Interestingly , among comorbidities , constipation and uncontrolled diabetes mellitus ( HbA1c ≥ @percent@ ) were also found to have positive associations with elderly cough.
Interestingly , among these factors are numerous components of the inflammatory pathways.
Interestingly , and as previously described , the severity of the changes differed among donors.
Interestingly , an inflammatory response , oxidative stress and activation of apoptotic pathways are common features in all these diseases.
Interestingly , a novel olive-pomace physical treatment to generate olive oil also yields by-products rich in functional antioxidants.
Interestingly , an unusual association seems to exist between the occurrence of these two pathological states , called \ "inverse comorbidity \ ".
Interestingly , a path analysis revealed that safeness and treatment function as mediators in linking loneliness to satisfaction.
Interestingly , a significantly greater number of hypotensive events were recorded during anesthesia.
Interestingly , at least some of the regulatory mechanisms are shared by functional membrane-less organelles and assemblies of terminally aggregated proteins.
Interestingly , autophagy , a catabolic pathway whose efficiency declines with age is importantly impaired in the affected tissues.
Interestingly , Avns had no effect on cell viability of confluence-induced differentiated Caco-2 cells , which display the characteristics of normal colonic epithelial cells.
Interestingly , BMI1 also acts as a repressor of miR-31 transcription , suggesting a cross-negative feedback loop between the expression of miR-31 and BMI1.
Interestingly , both neurological diseases are characterized by neurovascular damage.
Interestingly , both POGLUT1 and POFUT1 are essential regulators of Notch activity.
Interestingly , CA1-SRLM and ERC were the only MTL structures to atrophy in older controls relative to a younger comparison group.
Interestingly , Ca ( 2 + ) handling is modulated by age to a lesser degree in females.
Interestingly , cabazitaxel bears substantial structural similiarity to docetaxel but appears to be mechanistically distinct.
Interestingly , CAP1 was upregulated in knockout unwounded skin and in wounds which might partially compensate for the loss of CAP2.
Interestingly , caveolin-1 ( Cav-1 ) , a cholesterol binding and scaffolding protein , regulates neuronal signal transduction and promotes neuroplasticity.
Interestingly , dietary interventions can modulate this pathway.
Interestingly , differences may exist in the non-genomic pathways utilized by thyroid hormone metabolites and T3.
Interestingly , disease severity of virus-infected patients is wide-ranging.
Interestingly , EMS maintained IκB content without inhibiting the phosphorylation of MAPKs , which are well-established upstream kinases of NF-κB.
Interestingly , EMT and senescence seem to cross paths , with several factors playing dominant roles in both settings.
Interestingly , epigenetic mechanisms , such as DNA methylation and sirtuin1 ( SIRT1 ) are necessary for both circadian rhythms and memory.
Interestingly , exogenous administration of GD3 ganglioside was capable of reactivating the autophagic process inhibited by fumonisin B1.
Interestingly , FDP diminished the amplitude of Ca ( 2 + ) fluxes through down-regulation of SERCA2.
Interestingly , females were found to be higher functioning than males in all domains , including Communication , Daily Living Skills and Socialization.
Interestingly , few studies examined the association between frailty and specific cognitive functions and domains , reporting a significant impairment of attention and executive functions.
Interestingly , FGF23 has very low affinity for its receptor and requires the activity of Klotho , an anti-aging gene , to become active.
Interestingly , FIM scores were significantly lower in patients with both cerebrovascular disease and a loss of posterior occlusion.
Interestingly , genes with these DMRs were enriched in age-related diseases , including type-2 diabetes , cardiovascular disease , stroke and Alzheimer's disease.
Interestingly , GM1-stimulated macrophages secreted monocyte chemoattractant protein-1 ( MCP-1 / CCL2 ) through a CD206 / γc / STAT6-mediated signaling pathway and induced angiogenesis.
Interestingly , heparan sulfate was found to be degraded in sun-exposed skin , but not in sun-protected skin.
Interestingly , high spousal support was both associated with reduced overall NA means but also with an increased covariation in NA between partners.
Interestingly , homocysteine-stimulated but not angiotensin II-stimulated ECs senescence could be reversed by hypermethylation induced by folic acid or s-adenosylmethionine supplementation.
Interestingly , however , out-migration of adult children was independently associated with higher utilization of health services.
Interestingly , HSPBP1 protein levels were down-regulated during aging.
Interestingly , human Mitofusin-2 rescues the loss of LD but both Mitofusin-1 and Mitofusin-2 are required for steroid-hormone synthesis.
Interestingly , IGF-1 is negatively correlated with longevity , and suppression of IGF-1 signalling in worms , flies and mice increases lifespan.
Interestingly , IL-8 , the main mediator regulating glioblastoma cell invasion , was suppressed in both transcriptional and protein level.
Interestingly , imbalance between mitochondrial proliferation and degradation process results in progressive development of numerous pathologic conditions.
Interestingly , improvements in the inflammatory profile were found to be largely independent of obesity.
Interestingly , inactivation of Lats kinase is observed after EGCG treatment , which is responsible for the production of dephosphorylated TAZ.
Interestingly , in all the mouse models , A2E distribution and lipofuscin fluorescence correlate well.
Interestingly , increased autophagy is positively correlated with increased interferon-γ production.
Interestingly , increased tryptophan catabolism was associated with the depressive symptoms of lassitude , reduced motivation , anorexia , and pessimism.
Interestingly , inhibition of ã-secretase activity with Compound-E ( @number@ ìM ) prevented Cofilin1 phosphorylation / inactivation through an increase of SSH1 activity in PCNs.
Interestingly , in long-lived Ames dwarf mice , renal FXR and TGR5 expression levels were also increased.
Interestingly , in our mouse model , AD increased RAGE expression , and DM worsened CAA.
Interestingly , in skin stem cells , BMPs repress their proliferation but are indispensable for the proper differentiation into several lineages of skin cells.
Interestingly , levels of Na ( v ) 1.2 and Na ( v ) 1.6 α-subunits also decreased in 1-month-old BACE1-null mice.
Interestingly , long-term resistance exercise training is effective as a therapeutic intervention to augment skeletal muscle mass , and improves functional performance in the elderly.
Interestingly , loss and gain of miR-574-3p function in MCF-7 cells causes CLTC to be upregulated and downregulated , respectively.
Interestingly , low baseline motor status , but not cognitive status , predicted positive training response.
Interestingly , macrophages were also found to enrich in small foci of altered hepatocytes containing liver tumor-initiating cells ( TICs ) .
Interestingly , many features of RCNA are also found in processes involving DNA replication-independent nucleosome assembly like histone exchange and gene transcription.
Interestingly , many organs house both slow-cycling and fast-cycling SC populations , which rely on the coexistence of quiescent and inductive niches for proper regulation.
Interestingly , metagenome functions associated with circulating and brain iron stores are involved in bacterial generation of siderophores.
Interestingly , methylation at m6A by METTL3 / METTL14 facilitates the methylation of m5C by NSUN2 , and vice versa.
Interestingly , mice deficient in p21 have defects in embryonic senescence , AER maintenance , and patterning.
Interestingly , most of these proteins had been reported in some sulfur mustard-related studies in late and acute phases separately.
Interestingly , most of these stresses activate autophagy , a self-protective mechanism by which dysfunctional protein and organelles are degraded.
Interestingly , muscular mitochondrial complex I deficiency occurred in the skeletal muscle of mice exposed to D-gal.
Interestingly , muscular overexpression of SUMO-1 or @number@ resulted in morphological changes of the posterior part of the nematode.
Interestingly , NANOG worked together with transforming growth factor-beta1 to further enhance the contractility of senescent microtissues.
Interestingly , no difference in body mass index was observed.
Interestingly , no lipofuscin granules were found in CMs of human newborns and children.
Interestingly , @number@ of these variants were previously reported in Chinese Niemann-Pick disease patients.
Interestingly , offset analgesia was nonexistent on the palm for all subjects.
Interestingly , older age was also associated with a sharper rise and fall of negative affect.
Interestingly , one study suggested that dual-task walking speed can be used to predict prospective frailty development.
Interestingly , only minute changes in nucleolar association are observed upon senescence.
Interestingly , only @number@ fALS patient had the FUS mutation , whereas @number@ sALS patients had mutations in this gene.
Interestingly , only specific disulfide bonds are reversible while others are not.
Interestingly , OSA severity , sleep fragmentation , and obesity correlated with increased perfusion in subcortical and medial cortical regions.
Interestingly , P2X1 receptor appears to mediate the cells ' response to extracellular ATP.
Interestingly , patients with AD showed a decreased proportion of CMV-specific CD8 cells but no difference in general CD8 differentiation.
Interestingly , patients with poor quality of life were less often anticoagulated.
Interestingly , PKA and EPAC act synergistically to induce neuronal differentiation in N1E-115.
Interestingly , post exercise f was negatively associated with fat infiltration with the latter being significantly higher in late-middle-aged subjects.
Interestingly , protein levels of RBPs change across the aging spectrum and may be linked to other age-related disorders , such as type @number@ diabetes.
Interestingly , proteins related to oxidative stress , PON1 , haptoglobin , α ( @number@ ) -microglobulin , and clusterin , were altered in SSCs.
Interestingly , PTX-3 did not correlate with hs-CRP , but was positively correlated with adiponectin.
Interestingly , recent studies also show that there is a sensory influence on lifespan that requires the modulation of hormonal signaling activities.
Interestingly , reduction in NLRP3-mediated inflammation prevents age-related insulin resistance , bone loss , cognitive decline , and frailty.
Interestingly , research indicates a key role of this pathway in regulation of cardiomyocyte proliferation and heart size.
Interestingly , ROCK-mediated carbachol-induced contractions were positively correlated to the age of patients ( r = o.52 , P < 0.05 ) .
Interestingly , rs4073366 C variant carrier status was associated with OHSS risk.
Interestingly , sarcopenia has been associated to a deficit of sex hormones which decrease upon aging.
Interestingly , satisfied women exercised more than dissatisfied women , and weight and shape still played a primary role in their self-evaluation.
Interestingly , similar labelling patterns were evident in diabetic and non-diabetic patients.
Interestingly , simple senescence of middle-aged repertoires is insufficient to describe the older clonotype distribution.
Interestingly , Sirt1 physically interacts with HNF-1αin vitro but does so in vivo only in nutrient-restricting conditions.
Interestingly , some methods have the potential to attenuate the loss of muscle mass and strength such as exercise , and supplement intake.
Interestingly , some of the identified recruiting steps take place in the nucleus.
Interestingly , some of these molecules display anti-proliferative activity and sensitize cells to therapeutically relevant genotoxins.
Interestingly , SQ22536 ( an adenylate cyclase inhibitor ) and ZM241385 ( a potent A2A receptor antagonist ) attenuated the antiplatelet effect of chlorogenic acid.
Interestingly , the abnormal muscle and lipodystrophic phenotypes were common in both cases.
Interestingly , the age-associated DNAm increases or decreases of the normal signature were aberrantly accelerated in cancer samples.
Interestingly , the effect on ubiquitination was conserved in human cells , suggesting a novel mechanism regulating histone deubiquitination in higher organisms.
Interestingly , the fibrillar seeds of all amyloidogenic proteins functioned as seeds.
Interestingly , the group of older adults with a lower educational level showed an increased semantic interference effect during face naming.
Interestingly , the identified proteins are mainly involved in processes aimed at fine tuning embryo implantation and development.
Interestingly , the immediate early gene product Arc may also be the downstream signaling molecule of several receptors in the synaptic activity-modulated Aβ levels.
Interestingly , the increased expression of involucrin after UV exposure was suppressed by treatment with the MAAs mycosporine-Gly and shinorine , but not porphyra-334.
Interestingly , their programmed death stands a testimony to their cell-hood.
Interestingly , the levels of both total and phosphorylated biliverdin reductase-A were unchanged as well as its enzymatic activity in the cerebella.
Interestingly , the levels of KDM5B and its SUMOylated forms are regulated during the cell cycle.
Interestingly , the levels of PEN formation differed pronouncedly between glucosylation and ribosylation.
Interestingly , the modules were collapsed with AD progression , specifically in the EC region.
Interestingly , the neurobiological relevance of the relevant parameter at the individual level describes specific differences associated with aging.
Interestingly , the Nox4 gene is variably associated with specific DNA methyltransferases and methyl binding proteins in these two cell populations.
Interestingly , the @number@ kDa and @number@ kDa SMP30 forms appeared initially in the cytosol and shifted to the particulate fraction.
Interestingly , the patient carried the c.1639 C > T variant in the GRN gene , resulting in a R547C substitution.
Interestingly , the polycomb repressive complex @number@ ( PCRC2 ) target genes Kiss1r , Nav2 and Hsf4 were hypermethylated with age.
Interestingly , the presence , severity , and 10-year incidence of DR were additionally correlated with higher estimated cerebrospinal fluid pressure and shorter ocular length.
Interestingly , the protein regions of TDP-43 and Hrp38 responsible for reciprocal interactions are conserved through evolution.
Interestingly , there are an increasing number of genes that encode for various regulatory or structural cellular components that have been linked to hereditary bradyarrhythmias.
Interestingly , the regulation of senescence-related molecules by salidroside involved ROS-irrelevant mechanisms in both models.
Interestingly , there is a significant overlap between brain areas characterized by metal ion dyshomeostasis and those where BDNF exerts its biological activity.
Interestingly , the response to stress conditions and quality control mechanisms is impaired in PD , as well as in other neurodegenerative disorders.
Interestingly , there was also a significant increase in plasma GLP-1 in these aged mice.
Interestingly , these are also geographic regions with very heavy pollution.
Interestingly , these cells exhibit an impaired mitochondrial function and morphology under baseline conditions.
Interestingly , these functional beverages may be used differently between men and women , reflecting the \ "yin-yang \ " philosophy of Chinese medicine.
Interestingly , the selective activation of IL-1β transcription by SIRT1 deficiency is likely mediated through hypomethylating the specific CpG sites on IL-1β proximal promoter.
Interestingly , these mice exhibited spongiform neurodegeneration in motor cortex , hippocampus , and brainstem , accompanied by gliosis.
Interestingly these regions are known to be sensitive to normal and neuropathological aging processes.
Interestingly , these same animals are characterised by an outstanding ability to maintain correct proteostasis during their entire life.
Interestingly , the single base deletion on FUS was observed in an homozygous state , suggesting a recessive pattern of inheritance.
Interestingly , the spatial patterns of Aβ deposition in the brain might correlate with increased aerobic glycolysis in those regions.
Interestingly , the strongest expression of cyclin K is detected in primary spermatocytes.
Interestingly , the transgenic rats did not show neuronal loss either in the cortex or in the hippocampus.
Interestingly , the ubiquitination of HSP72 was strongly reduced during aging , which revealed that BAG2 functionally counteracted the increased levels of CHIP.
Interestingly , they also presented with reduced myocardial ( @number@ ) I-metaiodobenzylguanidine uptake.
Interestingly , they exhibited strong competitive inhibition of hMTH1 in the hydrolysis of 8-oxo-dGTP.
Interestingly , this binding depends on the presence of Lys274 that is C-terminal to RRM3 and binding to equivalent DNA sequences occurs with similar affinity.
Interestingly , this differential methylation was often associated with altered mitochondrial gene expression.
Interestingly , this interplay between autophagy and lipid metabolism is bidirectional , as changes in the intracellular lipid content also contribute to modulating autophagic activity.
Interestingly , this process was mediated by the mitochondrial replisome independent of canonical DSB repair.
Interestingly , this Pro-Hyp enrichment in the skin was derived from Gly-Pro-Hyp hydrolysis , as the administration of pure Gly-Pro-Hyp peptide led to similar results.
Interestingly , this variation results in the creation of a new phosphorylation site that could cause reduced microtubule binding.
Interestingly , tPA protects murine and human OLs from apoptosis through an unexpected cytokine-like effect by the virtue of its epidermal growth factor-like domain.
Interestingly , TV viewing was negatively associated with episodic memory in older adults but not younger adults.
Interestingly ubiquitin depletion , histone de-ubiquitination and impaired DNA damage response are not restricted to PolyQ aggregates and are associated with artificial aggregating luciferase mutants.
Interestingly , volunteers´ age was significantly correlated to T2 time while that was not the case for other coincident cardiovascular risk factors.
Interestingly , walking bout duration variability was the most sensitive PA parameter for discriminating between three frailty levels ( AUC = 0.818 ) .
Interestingly , we discovered that most differentially expressed genes were affected by a subset of @number@ putative causal genes.
Interestingly , we found an increased Cofilin1 phosphorylation / inactivation with age and AD pathology , both in vivo and in vitro.
Interestingly , we found that the expression of both Fbx2 and PGC-1α was significantly decreased in the brains of aging Tg2576 mice.
Interestingly , we found that the family member NFIX is robustly induced when NS cells enter quiescence.
Interestingly , weight loss induced by SRT1720 is not sufficient to improve glucose tolerance.
Interestingly , we observed that the immune alteration in astrocytes was relatively more pronounced than in microglia.
Interestingly , we show that divalent cations and nucleotide concentration have a direct effect on helicase substrate stability.
Interestingly , when compared to calorie restriction which has been repeatedly shown to increase healthspan , these polyphenols activate similar molecular targets such as Sirt1.
Interestingly , whereas a significant part of the age influence was mediated by cognitive inhibition , age also directly impacted the SNARC effect.
Interestingly , WIF1 overexpression in glioblastoma cells induced a senescence-like phenotype that was dose dependent.
Interestingly , young Gadd45a ( - / - ) HSCs showed enhanced reconstitution ability in serial transplantation.
Interestingly , αTP and EPC-K1 also reduced the neutral lipid content of THP-1 cells and the phagocytosis of fluorescent Staphylococcus aureus bioparticles.
Interest in lamins increased after mutations in the LMNA gene were found to be associated with a variety of human disorders termed laminopathies.
Interest in mind wandering ( MW ) has grown in recent years , but few studies have assessed this phenomenon in older adults.
Interest in -synuclein has increased markedly following the discovery of a relationship between its dysfunction and several neurodegenerative diseases , including Parkinson's disease.
Interest in the practice of narrative care with older adults is continuing to grow ( Kenyon & Randall , @number@ ) .
Interest in yoga is growing , especially among older adults.
Interest is rapidly growing around the role of the human gut microbiota in facilitating beneficial health effects associated with consumption of dietary fiber.
Inter-ethnic differences will be explored.
Interference is believed to be caused by limitations in central processing , i.e. structural interference between the neural activation patterns associated with each task.
Interference with FLT3ITD signaling is therefore pursued as a promising therapeutic strategy.
Interferon signature genes were upregulated in SMS individuals ' blood and dental cells.
Intergenerational caregiving for frail older people has become a challenge for policies aimed at keeping the aging population in the community.
Intergenerational links are examined , along with differences between chronological and functional age , chronic health impairments and disabilities in daily living.
Intergenerational service learning is frequently used in gerontology courses.
Intergenerational transmission of risk factors from parents to offspring may play an important role , especially for tobacco-related cancers.
Interhemispheric-frontal pathways ( genu of the corpus callosum ) were associated with both types of mnemonic function.
Interhemispheric genetic correlations were high and significant ; in only two subcortical regions ( pallidum and accumbens ) did the estimate statistically differ from @number@
Interhemispheric interactions play a key role during such bimanual movements to prevent interference from the opposite hemisphere.
Interictal memory disturbances consist of autobiographic memory disorders and long term forgetting.
Interim analysis was used for member checking and triangulated data from other recent studies were used to increase the trustworthiness of findings.
Interim partial dentures are used often to temporarily restore a patient's dentition to create a satisfactory phonetic , esthetic , and occlusal relationship.
Inter-individual differences exist in the rate at which a person ages ( biological age ) .
Inter-individual DMRs were readily detectable in these regions.
Inter-individual heterogeneity is evident in aging ; education level is known to contribute for this heterogeneity.
Inter-individual quantitative variations of active families of aL1 repeats in the genome were observed.
Interindividual variability in sympathetic nerve activity ( SNA ) has provided insight into integrative mechanisms contributing to blood pressure ( BP ) regulation in humans.
Interindividual variability in the disposition and action associated with similar doses of a given medication is an inherent characteristic of both adult and pediatric populations.
Interindividual variability of telomere length may partly explain differences in reproductive aging rates.
Interindividual variation in intraindividual change patterns was considerable in most domains.
Inter-item correlations were moderate to high within domain and low to nil across domains , indicating construct validity.
Interleukin-17A ( IL-17A ) is an important pro-inflammatory cytokine that regulates leukocyte mobilization and recruitment.
Interleukin-1 receptor type @number@ ( IL1R2 ) gene expression was significantly increased in aged , but not young skin , after cytokine treatment.
Interleukin-1β ( IL-1β ) is considered to have a role in age-related cognitive decline.
Interleukin-1β treatment restored LC migration in aged epidermis whereas TNF-α was without effect.
Interleukin-21 ( IL-21 ) is a T cell-derived cytokine modulating T cell , B cell , and natural killer cell responses.
Interleukin-6 ( IL-6 ) produced by irradiated keratinocytes is proposed to have a role in metalloproteinases ( MMPs ) expression activation in dermal fibroblasts.
Interleukin-6 ( IL-6 ) was identified as a regulator of mIndy by binding to its cognate receptor.
Interleukin-6 , soluble interleukin-6 receptor ( sIL-6r ) , and soluble glycoprotein @number@ ( sgp130 ) were measured on plasma by ELISA.
Interleukin-6 was measured at baseline and @number@ years earlier.
Interleukin-7 ( IL-7 ) plays a central , critical role in the homeostasis of the immune system.
Interleukin-8 and monocyte chemoattractant protein-1 levels were higher in HAND compared with NC at baseline ( P = @number@ and P < @number@ ) .
Interleukin-8 ( IL-8 ) is postulated to be a chronic stress biomarker.
Interleukin ( IL ) -1β reportedly leads to accumulation of amyloid β via nitric oxide stress in vitro.
Interleukin ( IL ) -2 , tumor-necrosis factor , interferon-γ , and perforin production were analyzed using enzyme-linked immunosorbent assay.
Interleukin ( IL ) -4 responses were slightly stronger for six peptides , and significantly stronger for Nc16a , in patients than in controls.
Interleukin @number@ ( IL-15 ) controls both the homeostasis and the peripheral activation of natural killer ( NK ) cells.
Interleukins ( IL ) IL-6 , IL-18 , IL-10 , and high sensitivity C-reactive protein were measured using bead-based multiplex assay.
Intermediate and generalized atherosclerosis was identified in @percent@.
Intermediate filament ( IF ) proteins comprise a large family with more than @number@ members.
Intermediate filaments ( IFs ) , together with actin filaments and microtubules , form the cytoskeleton - a critical structural element of every cell.
Intermediate half-life and long half-life benzodiazepine use were each associated with two measures.
Intermediate-length polyglutamine expansions in ataxin @number@ are a risk factor for amyotrophic lateral sclerosis ( ALS ) .
Intermediate-moisture , dried , and chemically modified honeys are also used.
Inter-method agreement between clinic BP and ABPM in different age groups was assessed using the Kappa ( κ ) coefficient.
Intermittent and constant knee pain were independent factors in self-perceived physical function and were important predictors of future limitations in physical function.
Intermittent claudication is a form of exercise intolerance characterized by muscle pain during walking in patients with peripheral artery disease ( PAD ) .
Intermittent claudication , rest pain , intractable foot ulcer and gangrene are the manifestations of PAD patients.
Intermittent fasting may also be useful as an accompanying treatment during chemotherapy of cancer.
Intermittent GVS decreased the excessive postural sway induced by the concurrent visual and proprioceptive perturbation in young but not in elderly participants.
Intermittent parathyroid hormone ( PTH ) increases the volume of bone formed by existing BMUs and those generated by PTH administration.
In terms of adaptation to the residence , participation in recreational activities exhibited this mediational sequence : leisure motivation for leisure→adjustment to nursing homes.
In terms of age differences , older adults had shorter and stiffer feet.
In terms of anti-tumor activity , @number@ mg / kg of clone @number@ was equivalent to @number@ mg / kg of bevacizmab.
In terms of catabolism the ubiquitin proteasome system , apoptosis , autophagy , inflammation , oxidation and insulin resistance are among the major mechanisms proposed.
In terms of conceptual implications , present findings underline the importance of cue detection for prospective remembering and reveal different developmental trajectories for cue detection.
In terms of cutoffs of each parameter , using the lowest quintile showed better predictive values in mortality than using the FNIH-recommended values.
In terms of decision style , personality characteristics were not related to performance.
In terms of falls prevention , high-challenging balance training programs appear to be most effective.
In terms of gender , employed men reported higher BMI than their unemployed counterparts , whereas employed women reported lower BMI than did unemployed women.
In terms of gender , the majority of the participants ( @percent@ ) were male.
In terms of health status , NP-only patients are similar to PCMD-only patients.
In terms of health status , patients utilizing only NPs in their primary care were not statistically different from patients utilizing only PCMDs.
In terms of its validity , the MoCA is better in the detection of AD than aMCI in Cantonese-speaking Chinese persons.
In terms of lifestyle intervention opportunities , this study also highlights the significance and feasibility of such interventions for BMI as a modifiable risk factor.
In terms of ministry standards , participants reported barriers to complying with rotation and portion standards.
In terms of mortality among men and in terms of hospitalizations for most age groups , the respondents represented the population fairly well.
In terms of movement adaptations , we have shown that children , like adults , spatially and temporally tailor their movements to aperture size.
In terms of personal care assistance , women received more years of assistance than men.
In terms of priority to actually implement enhanced patient-centred care options , timely access was universally dominant among all stakeholders.
In terms of senescence , distinct differences are found among organs in a patient with Cockayne syndrome.
In terms of social support , decreased social interaction , and instrumental social support predicted decline in cognitive performance.
Internal carotid artery flows were significantly higher with a fetal PCA and decreased with a hypoplastic anterior cerebral artery.
Internal carotid artery stenosis accounts for about 7-10 % of ischemic strokes.
Internal consistencies were @number@ and @number@ for the Mainstream and Heritage subscales respectively , and they were orthogonal.
Internal consistency / agreement and correlations between the SIB and SIB-8 and other clinical end points were evaluated.
Internal consistency / agreement between the full SIB and SIB-8 was good ( Cronbach's alphas : @number@.77-0.95 ) .
Internal consistency and reliability were assessed by means of inter-item and test-halves correlations and Cronbach's alpha.
Internal consistency and test-retest reliability were assessed using Cronbach α and correlation coefficients , respectively.
Internal consistency coefficients were satisfactory for the full scale of PSS-13 and PSS-10 but not for PSS-4.
Internal consistency ( Cronbach's alpha ) was acceptable for most of the DQoL scales.
Internal consistency estimates of reliability of the MBI-HSS were determined using Cronbach's alpha.
Internal consistency of the derived scale scores was assessed with Cronbach's α.
Internal consistency of the different scales reached from α = @number@ to α = @number@
Internal consistency was assessed using Cronbach alpha.
Internal consistency was calculated using Cronbach's alpha.
Internal consistency was good ( Cronbach α @number@ and @number@ ) , and test-retest reliability was fair ( ICCs @number@ and @number@ ) .
Internal consistency was investigated by calculating Cronbach's alpha.
Internal fixation of intracapsular fractures have demonstrated satisfactory early outcome in the immediate period.
Internal fixation with locked plating is the current mainstay of treatment for functionally active patients who desire minimal loss of function.
Internal HOAs , supposedly generated from cataract progression , may be associated with systemic factors , including serum creatinine levels and blood pressure.
Internalization of Pt into the whole body and mitochondria was similar between these two strains.
Internal medicine physicians are in a pivotal position in this regard.
International articles are included.
Internationally , the direct costs of stroke constitute @percent@ of national health spending , this being similar amount in different countries around us.
Internationally , there is a lack of studies focusing on older women , who comprise the majority of the ageing population.
International study groups have recently proposed separate definitions and diagnostic criteria for sarcopenia.
Internet based health information has influenced patient knowledge and expectations regarding healthcare.
Internet-based programs that promote healthy practices have also shown promise and , therefore , should be especially appropriate for workers aged @number@ years and older.
Internet mediated interventions hold great potential in implementing effective lifestyle programs , capable of reaching large populations of older persons at very low costs.
Internet searches retrieved additional HZ immunisation guidelines.
Internet use was higher in younger , male , White , wealthier , more educated respondents , and those without physical limitations.
Internet use was recorded at each wave.
Internists are on call an average of @number@ times a month and perform @number@ discharges , @number@ outpatient visits and @number@ consultations in a year.
Interobserver agreement in readings was also assessed by the Bland-Altman Method.
Inter-observer and intra-observer variability and the agreement of LAV measurements between RT3DE and 2DE were assessed in a subset of subjects.
Inter observer reliability of an ADR classification system by different healthcare providers is vital to establish the validity of the reaction.
Interobserver reliability was good for each measurement ( r = 0.569 to @number@ P < 0.01 ) .
Inter-observer reliability was rated very good ( kappa values between @number@ and @number@ ) and perfect for intra-observer reliability ( @number@ ) .
Interobserver reproducibility coefficients ranged from @number@ ( TM length ) to @number@ ( TM area ) .
Inter-organelle membrane contact sites ( MCSs ) serve as unique microenvironments for the sensing and exchange of cellular metabolites and lipids.
Interpersonal sensitivity , excessive sensitivity to the behavior and feelings of others , is one of the vulnerable factors to depression.
Interpersonal sensitivity was assessed by the Japanese version of the Interpersonal Sensitivity Measure ( IPSM ) .
Interphase FISH for IG and PAX5 gene rearrangements was performed on @number@ cases of DLBCL.
Interpolated age- and gender-specific estimates of sarcopenia prevalence were then applied to population projections until @number@
INTERPRETATION : Absolute and relative accuracy of AHRS are affected by environmental magnetic perturbations and conditions of motions.
INTERPRETATION : Age had minimal effects and fall history had no effects on joint kinetics of steps to similar distances.
INTERPRETATION : Age-related BTL attrition was faster in cancer cases but their age-adjusted BTL attrition began decelerating as diagnosis approached.
INTERPRETATION : Age-related changes in muscle geometry and posture may partly account for the deterioration in muscle function in the elderly.
INTERPRETATION : Aβ deposition increases slowly from cognitive normality to moderate severity DAT.
INTERPRETATION : CAA pathology is very common in older community-dwelling persons and is associated with AD pathology.
INTERPRETATION : Cognitive performance over the adult life course was remarkably higher in the high reserve groups.
INTERPRETATION : Crowdsourcing of the general public to classify cancer pathology data for research is viable , engages the public and provides accurate ER data.
INTERPRETATION : CSF NfL is elevated in symptomatic FTD and correlates with disease severity.
INTERPRETATION : Diabetes is associated with poor performance on cognitive tests of information-processing speed and executive function.
INTERPRETATION : Disease duration , clinical course , age , and gender contribute to the dynamic nature of white matter MS pathology.
INTERPRETATION : Each PPA clinical variant is associated with a typical and most frequent cognitive , neuroimaging , and neuropathological profile.
INTERPRETATION : Effective age-appropriate care requires sensitivity to the unique needs of older people newly diagnosed with cancer.
INTERPRETATION : Endogenous Aβ₄₂ is a critical player in synaptic plasticity and memory within the normal central nervous system.
INTERPRETATION : Expansion of ART in Botswana was associated with decreased age-specific cancer risk.
INTERPRETATION : Health care providers should consider the importance of weight management and physical activity to prevent and treat fatigue in this population.
INTERPRETATION : Higher adherence to the MeDi is associated with reduced cerebrovascular disease burden.
INTERPRETATION : Higher SFA intake was associated with worse global cognitive and verbal memory trajectories , whereas higher MUFA intake was related to better trajectories.
INTERPRETATION : Hip fracture can lead to a substantial loss of healthy life-years in elderly people.
INTERPRETATION : Immigrant seniors , especially recent arrivals , had lower odds of hospitalization and similar time in hospital , compared with Canadian-born seniors.
INTERPRETATION : Increased plasma concentrations of 25 ( OH ) D might reduce the risk of hypertension.
INTERPRETATION : Information on how and why trends vary by cancer can inform resource allocation planning.
Interpretation is supported by calculated parameters such as the Reticulocyte Production Index.
INTERPRETATION : Nutritional risk is common among seniors living in private households in Canada.
Interpretation of cognitive change has been complicated because different influences on change are not easily distinguished.
Interpretation of MR images of the spine in the absence of prior imaging is not uncommon.
Interpretation of these measurements relies on the availability of appropriate reference equations.
Interpretation of verbal fluency performances need to be tailored according to which verbal fluency variant and age group are used.
INTERPRETATION : Older participants appeared to control the detrimental effects of fatigue associated with repetitive lifting and limit lumbar spine range of motion.
INTERPRETATION : Our analysis revealed that patients older than @number@ had significantly more risk of hepatotoxicity.
INTERPRETATION : Our findings confirm that GWAS discoveries for asthma are associated with a childhood-onset phenotype.
INTERPRETATION : Our model provides a potential new approach to distinguish participants with Parkinson's disease from controls.
INTERPRETATION : Our results indicate that PLXNA4 has a role in AD pathogenesis through isoform-specific effects on tau phosphorylation.
INTERPRETATION : Perceived poor work ability in midlife was associated with accelerated deterioration in health and functioning and remains evident after @number@ years of follow-up.
INTERPRETATION : Preclinical Alzheimer's disease is common in cognitively normal elderly people and is associated with future cognitive decline and mortality.
INTERPRETATION : Quantitative mobility subtask measures vary in their associations with parkinsonian gait scores and other parkinsonian signs in older adults.
INTERPRETATION : Reduced HRV is significantly associated with lower cognitive performance at a population level in people aged @number@ and older.
INTERPRETATIONS : Older adults generate propulsive forces slowly and reach lower magnitudes , mainly during step preparation.
INTERPRETATIONS : Persons with mild-to-moderate Parkinson disease display disparities in rate of force development , even without deficits in maximal force.
INTERPRETATIONS : The decreased friction and damping ratio present challenges for the control of everyday prehensile tasks.
INTERPRETATIONS : These data suggest that inherited or acquired changes in SORCS1 expression or function may play a role in the pathogenesis of AD.
INTERPRETATION : Subtle memory impairment with a positive β-amyloid scan identifies healthy individuals at high risk for MCI or AD.
INTERPRETATION : TBI patients ' brains were estimated to be older than their chronological age.
INTERPRETATION : TDP-43 should be considered as a potential factor related to increased rates of hippocampal atrophy in patients with Alzheimer's disease.
INTERPRETATION : The chromosome 9p21 locus is a major cause of familial ALS in the Finnish population.
INTERPRETATION : The combined roles of HS and TDP-43 pathology are significant factors underlying global cognitive impairment and probable AD in older subjects.
INTERPRETATION : The major advances in cancer management that occurred up to @number@ seem to have resulted in improved survival in Europe.
INTERPRETATION : These categories can be used in future work on cognitive functioning based on the CCHS Healthy Aging.
INTERPRETATION : These findings highlight that older adults were unable to exert the same vertical-axis control during single-support as young subjects did.
INTERPRETATION : These findings reveal an interplay between mitochondrial DNA , pathophysiology of TBI , and aging.
INTERPRETATION : These trends are encouraging.
INTERPRETATION : The statistical association and the functional evidence suggest that mutations of the GABRG2 gene may increase the risk of RE / ARE.
INTERPRETATION : The use of each grab bar while performing a lateral step over an obstacle may help maintaining balance in lateral and vertical directions.
INTERPRETATION : This is an observational study , so causal conclusions cannot be drawn.
INTERPRETATION : This study , for the first time , presents an ultrasonography based in vivo method for measurement of free AT mechanical properties.
INTERPRETATION : Transmissibility of whole body vibration while standing is not markedly different between children and adults.
INTERPRETATION : We found no evidence for a neuroprotective effect of cardiorespiratory fitness as of midlife.
INTERPRETATION : We noted regional abnormalities associated with known neurological and behavioural deficits in patients with classic Lesch-Nyhan disease.
INTERPRETATION : We observed age-related reduced strength and flexibility concomitant with alterations in running biomechanics , but a lack of correlation between these variables.
INTERPRETATION : We provide evidence that @number@ common variants within the TREM locus are associated with pathological features of AD and aging-related cognitive decline.
INTERPRETATION : With the aging of the baby boomer generation , an increasing number of people with mobility impairments will be seeking healthcare services.
Interpreted from a life course perspective , financial supports were deemed sufficient , despite overall limited financial means.
Interpreting individual results relies on accurate reference intervals and decision limits.
Interpreting patient descriptions of signs and symptoms may be the first cues prior to diagnosis.
Interprofessional education ( IPE ) for healthcare professionals is important in Japan because of its rapidly aging population and increasingly complex healthcare needs.
Interprosthetic femoral fracture is a rare and challenging fragility fracture issue.
Interrater agreement ranged between @percent@ and @percent@.
Inter-rater and inter-method reliability was accomplished both globally and regionally.
Inter-rater and intra-rater reliabilities were also excellent with ICC correlations of @number@ and @number@ respectively.
Interrater and intrarater reliability was assessed using intraclass correlation coefficients ( ICCs ) .
Interrater reliability for the high-definition videos was @number@ ( @percent@ confidence interval , .94-.97 ) .
Inter-rater reliability of EFAT2 was examined using a sample of four participants recruited from a cancer care ward.
Inter-rater reliability using an ICC was significant and acceptable except for GLI.
Interrater reliability was measured with the Kappa statistics and interclass correlation coefficients.
Interrater weighted kappa scores were @number@ for the IRP and @number@ for investigators.
Interregional correlations of binding potential ( BP ) values were high for areas within DA pathways in younger and elderly adults alike.
Interrelationships among different correlates of OD can offer insights into the underlying mechanisms , but to date remain understudied.
Interrogation and clinical examination usually allow understanding its mechanism , but some additional explorations may be necessary.
Interruption of antiplatelet or anticoagulant oral agents in the perioperative period may increase the risk of coronary or cerebral events.
Inter-scanner variability was considerably higher than intra-scanner precision , even in cases where the mean inter-scanner difference was statistically insignificant.
Inter-species correlations were found among each species , exception for B. animalis ssp. lactis.
Interstate migration in the United States has decreased steadily since the 1980s , but little is known about the causes of this decline.
Interstitial concentration of amyloid beta ( Aß ) is positively related to synaptic activity in animal experiments.
Interstitial fluid alterations may account for some WMH reversibility , offering potential intervention targets.
Inter-subject heterogeneity of responses was particularly noticeable in the combined training group.
Interuser and intrauser variability was measured.
Interuser and intrauser variability were acceptable.
Intervening hospitalizations and MMD , defined as the inability to walk @number@ m , were assessed every @number@ months for up to @number@ years.
Intervening in this aging process thus protects against the totality of age-related diseases.
Intervening with high-risk older veterans after an ED visit may reduce unscheduled healthcare use.
Intervention adherence was measured using a Video Status Report embedded into electronic medical record systems.
INTERVENTION : After a 1-week analgesic washout , patients applied @number@ g of DSG or vehicle four times daily to one knee.
INTERVENTION : After lifelong supplement of riboflavin , the lifespan and the reproduction of fruit flies were observed.
INTERVENTION : A health- and diet-related questionnaire was applied to participants house-to-house by trained health professionals.
Interventional efforts may require different strategies , as groups with different characteristics were at risk.
INTERVENTION : All existing dental conditions were treated before enrollment.
INTERVENTION : All men underwent open RP.
Intervention : All participants received collaborative care for dementia.
INTERVENTION : All participants received the standard institutional diet.
INTERVENTION : All patients discharged to eight postacute care sites were discussed in a weekly videoconference.
INTERVENTION : All patients received either a unilateral or bilateral multichannel cochlear implant.
\ "Interventional medicine \ " certainly puts lifestyle modification as the first therapeutic step , including a healthy diet and physical activity.
Interventional studies are needed to establish causality and determine therapeutic implications.
Interventional studies are required to assess whether thromboembolism can be prevented in this high-risk population.
INTERVENTION : A multifaceted intervention design was used.
INTERVENTION : A national preventive care program including individualized actions.
Intervention and control participants both participated in physical activity sessions.
INTERVENTION : A new intervention group began the program every @number@ mo , with a maximum of @number@ individuals per group.
INTERVENTION : Arterialized venous blood was obtained at the year @number@ study visit and analyzed for pH and pCO2.
INTERVENTION : Articles that examined the effect of trained volunteer mealtime assistants on nutritional outcomes or satisfaction with mealtime care were included.
Intervention associations varied by race-ethnicity , BMI , diabetes , and HT and remained significant after adjustment for physical activity.
INTERVENTION : A surgical intervention into the body politic.
Intervention at @date@ was associated with a lower probability of recurrence ( HR @number@ CI [ @number@ @date@ ] ) .
INTERVENTION : Blood samples were taken for determination of serum parameters of thyroid function.
INTERVENTION : Blue light administration.
Intervention by telephone consultations may also prevent readmission , but only among participants who receive the full intervention.
INTERVENTION : Changes over time in ED geriatric services , observed naturalistically.
Intervention consisted of an 8-week training comprising @number@ half-hour sessions.
Intervention consisted of four individual sessions of Life Review , structured along @number@ questions aimed at prompting autobiographical memory specificity.
INTERVENTION : Daily capsule containing cholecalciferol @number@ IU daily or placebo for @number@ months.
INTERVENTION : Daily multivitamin or placebo.
INTERVENTION : Daily multivitamin or placebo.
INTERVENTION : Each individual underwent a standardized neuropsychological test session , magnetic resonance imaging , and positron emission tomography scanning.
Intervention effectiveness was based on randomized controlled trial results.
Intervention effect sizes were equal ( @number@.47-0.59 ) .
INTERVENTION : Eight-week muscle strength exercise intervention focused on lower limb strength exercises of light to moderate intensity.
INTERVENTION : Five of the patients with PU received Arginaid Water supplementation.
Intervention for stroke caregivers should recognize both the strains faced by caregivers and their capacity for successful coping over time.
Intervention group caregivers had significant improvements in outcomes representing unmet needs , three types of caregiver strains , depression , and two support resources.
Intervention group received calcium @number@ mg / d and cholecalciferol @number@ IU for @number@ years.
Intervention groups did not differ at baseline.
Intervention : Histology and immunohistochemical analysis on paraffin-embedded ovarian sections.
INTERVENTION : Human oocytes were analyzed with the use of NanoString or immunoblotting.
Intervention ( if any ) : On the intervention day nutritional supplement drinks were provided three times.
INTERVENTION : In study @number@ and study @number@ the tongue training lasted @number@ and @number@ minutes , respectively.
INTERVENTION : Intervention group participated in an individualized , one-on-one safe-transportation program adapted from the Knowledge Enhances Your Safety curriculum.
INTERVENTION : Intervention participants received a multicomponent curriculum including scripture readings , prayer , goal-setting , a community resource guide , and walking competitions.
INTERVENTION : Interventions included a 6-month caloric restriction diet alone or caloric restriction diet + resistance training.
INTERVENTION : Long-term care sites presented challenging cases regarding residents with dementia and / or delirium related behavioral issues to specialists via video-conferencing.
Intervention material use during the remainder of the intervention was compared for initial print- or Web-based participants.
INTERVENTION : NHs received FALLS alone ( control ) or CONNECT followed by FALLS ( intervention ) , each delivered over @number@ months.
INTERVENTION : None.
INTERVENTION : None.
INTERVENTION : None.
INTERVENTION : Once-daily trospium chloride @number@ mg XR or placebo.
INTERVENTION & OUTCOMES : Relative cost-effectiveness was assessed using cost-minimization analysis or incremental cost-effectiveness ratios.
Intervention participants averaged @number@ steps per week at baseline , compared with @number@ steps in controls.
INTERVENTION : Participants received @number@ mg / d DHEA or placebo for @number@ months ; all received calcium and cholecalciferol.
Intervention participants were also provided with pedometers.
Intervention participants were highly satisfied with the program.
INTERVENTION : Participants were randomized into treatment or control groups ( daily probiotics or placebo for @number@ consecutive days , respectively ) .
INTERVENTION : Participants were randomized to losartan , omega-3 fish oil ( ω-3 ) , combined losartan and ω-3 , or placebo.
INTERVENTION : Participants were randomized to one of three AChEIs in a 1 : 1 : 1 ratio and followed for @number@ weeks.
Intervention : Participants were randomly assigned to a 90-minute nap opportunity or an equal interval of quiet wakefulness.
INTERVENTION : Participants were randomly assigned to treatment with intravenous epoetin alfa or matching saline placebo administered within @number@ hours of reperfusion.
Intervention Participants were tested for AWP using @number@ minutes of water immersion with room-temperature tap water.
Intervention participants were then given the opportunity to interact with the ECA in a kiosk in their clinic waiting room for the following @number@ months.
INTERVENTION : PATH is a home-delivered intervention designed to reduce depression and disability in depressed , cognitively impaired , disabled elders.
INTERVENTION : Patients had access for @number@ months to a depression clinical specialist who coordinated depression care with their primary care physician.
Intervention : Patients underwent attended polysomnography while sleeping with therapeutic CPAP , or after CPAP withdrawal , in random order.
Intervention patients were immediately commenced on a malnutrition care plan ( MCP ) .
INTERVENTION : Patients were randomized to Um-PEA @number@ mg or placebo twice daily.
INTERVENTION : Patients were treated with poly-L-lactic acid.
INTERVENTION : Patients with IDA underwent gastroscopy and colonoscopy plus ileoscopy.
INTERVENTION : PBBT involved @number@ sessions a week for @number@ weeks.
INTERVENTION : Progressive resistance and balance training under the guidance of a physiotherapist for @number@ months , then facility-guided maintenance training for @number@ months.
INTERVENTION : PRT and cognitive training ( CT ) , @number@ to @number@ days per week for @number@ months.
INTERVENTION : Radial arterial pulse wave tonometry ( AtCor , SphygmoCor , Sydney ) performed opportunistically and sequentially on patients between @number@ and @number@
INTERVENTION : Research staff provided an 8-hour training curriculum to nonnursing staff.
INTERVENTION : Research staff provided cognitively stimulating activities daily for up to @number@ days.
INTERVENTION : Residents from four nursing homes were randomly selected for a nutrition education program coordinated by Nutrition Coordinators.
INTERVENTION : Retrospective review of medical records.
INTERVENTIONS : A 5-month , home-based , person-directed , structured program delivered by an interprofessional team : occupational therapist , registered nurse , and handyman.
INTERVENTIONS : A 72-hour continuous infusion of either glucagon-like peptide-1 ( @number@ pmol / kg / min ) or normal saline plus intensive insulin therapy.
Interventions addressing social interaction need to be sensitive to gender and age differences.
INTERVENTION ( S ) : AFC was measured by transvaginal ultrasound examination.
Interventions aimed at causative factors may help prevent conversion of frailty into disability.
Interventions aimed at changing age-related stereotypes in population may have more impact on reducing loneliness than individually based services.
Interventions aimed at improving HIV prevention , care , and treatment outcomes should incorporate HIV stigma reduction strategies as core elements.
Interventions aimed at improving the appropriateness and safety of antimicrobial prescriptions have been proposed.
Interventions aimed at increasing social support among this population might be beneficial in reducing cardiovascular disease risk.
Interventions aimed at maintaining muscle strength and area in old age might delay functional decline.
Interventions aimed at reducing chronic inflammation and immune activation in aging , HIV-infected patients may improve their response to vaccines.
Interventions aimed at reversing foot muscle atrophy in older people require further investigation.
Interventions aiming to promote health care engagement among this population should simultaneously consider both depression diagnosis and symptomatology.
Interventions and policies aiming to support aging in place should consider addressing household-level and street-level disorder.
INTERVENTIONS : Any DPP-4 inhibitor ( vildagliptin , sitagliptin , saxagliptin , linagliptin or alogliptin ) .
Interventions are crucial as they offer simple and inexpensive public health solutions that will be useful over the long term use.
Interventions are needed to increase PA in older adults in the years leading to and after the transition to retirement.
Interventions are needed to minimize the coverage gaps among subgroups and to improve overall vaccination rates.
Interventions are needed to support high-quality POLST decisions that are informed and concordant with current preferences.
INTERVENTIONS : A single 15-minute session of leg cycling and a 4-week cycling regimen.
INTERVENTIONS : A urethane foam insole with the piezoelectric actuators delivering subsensory vibratory noise stimulation to the soles of the feet.
Interventions based on workload reductions should help to keep workers on the job for as long as allowed by law.
INTERVENTION ( S ) : Baseline transvaginal ultrasound examination between days @number@ and @number@ of the menstrual cycle.
INTERVENTION ( S ) : Blood sampling for AMH level.
INTERVENTIONS : Canaloplasty.
INTERVENTIONS : Centiles were developed using quantile regression analysis , with cubic B-splines to model the centiles.
INTERVENTION ( S ) : Cervical and ocular vestibular evoked myogenic potentials ( VEMPs ) were used to assess saccular and utricular function , respectively.
INTERVENTIONS : Cochlear implantation.
INTERVENTION ( S ) : Collection of @number@ supernumerary oocytes that were not used during the IVF cycle from the above cited consenting patients.
Interventions comprised intramuscular injection of either placebo or @number@ mg testosterone undecanoate , given at weeks @number@ @number@ @number@ @number@ and @number@
Interventions consisted of a comprehensive medication review , improved discharge planning , post-discharge telephone follow-up , and liaison with the patient's general practitioner.
INTERVENTION : Screening colonoscopy.
INTERVENTION ( S ) : Cytogenetic analysis and molecular testing ( fluorescence in situ hybridization , microarray , whole-genome sequencing ) .
INTERVENTIONS : Depot GnRHa ( leuprolide @number@.75-mg ) .
Interventions designed to decrease depression-related mortality in later life may need to focus on ameliorating frailty in addition to treating depression.
Interventions designed to help caregivers become more attentive to specific pain cues might be important to pursue.
Interventions designed to improve oral health for older adults , particularly those with low levels of income , need special attention.
Interventions designed to improve outcomes in frail elders with CVD such as multidisciplinary cardiac rehabilitation are being actively tested.
Interventions designed to mitigate psychological distress and physical difficulties , and to promote social connectedness may help mitigate suicidality risk in this population.
Interventions designed to prevent sarcopenia and improve muscle strength may help reduce the burden of cognitive and physical impairments of functionality in community-dwelling seniors.
INTERVENTION ( S ) : Determining ovarian NGF counts with systematic random sampling rules and a validated fractionator / optical disector technique.
INTERVENTIONS : Diagnostic.
INTERVENTIONS : Dietary patterns that described themselves as using a ' Mediterranean ' dietary pattern.
Intervention ( s ) : Diet counseling was provided to all subjects.
INTERVENTIONS : Each patient received @number@ U of abobotulinumtoxinA on one side of the forehead and @number@ U of onabotulinumtoxinA on the other side.
INTERVENTION : Self-administered questionnaires collected data on patient characteristics , fracture risk factors , and previous fractures.
Interventions for older adults with balance problems should consider incorporating activities that involve the interaction with objects of various properties in the environment.
INTERVENTION : Shortly before discharge , patients in the intervention group received an individually-tailored nutrition plan.
INTERVENTION : Simple balancing exercise was performed at home every day and was recorded in the booklet.
INTERVENTIONS : Implementation of daily paired spontaneous awakening trials ( daily sedation vacation plus spontaneous breathing trials ) as a quality improvement project.
Interventions improving adherence and persistence to AChEIs may improve AD management.
Interventions , including organizational changes in CRC screening should be considered to reduce this variation.
Interventions in vitro , in vivo , and in humans will continue to contribute for a better understanding of these pathologies.
Interventions involving weight management and improvement of physical fitness may contribute to better sleep quality in older women.
Intervention : Skeletal muscle biopsies obtained during a primed-continuous infusion of l- [ ring-13C6 ] -phenylalanine.
Interventions may incorporate the environmental aspect to reduce cognitive and common mental disorders.
Intervention ( s ) - Measurement ACTH , cortisol and their ratio ( ACR ) .
INTERVENTIONS : Measurement of aortic pulse wave velocity ( PWV ) by arterial tonometry.
INTERVENTIONS : Mice underwent one of two severity polytrauma models of injury.
INTERVENTIONS : Moderate PA including walking , resistance and balance training compared with HE consisting of topics relevant to older adults.
INTERVENTIONS : Morning blood samples were collected at the study visit.
Interventions : Mutational status was determined by pyrosequencing method , allelic discrimination , or Sanger sequencing.
INTERVENTIONS : N / A. MEASUREMENTS AND RESULTS : All subjects underwent one full-night polysomnography.
INTERVENTIONS : N / A. MEASUREMENTS AND RESULTS : At approximately 5-yr intervals , respondents self-reported trouble initiating and maintaining sleep.
INTERVENTIONS : N / A. MEASUREMENTS AND RESULTS : In-home PSG was performed which included bilateral measurement of leg movements.
Intervention ( s ) : None.
Interventions : None.
INTERVENTION ( S ) : None.
INTERVENTION ( S ) : None.
INTERVENTION ( S ) : None.
INTERVENTION ( S ) : None.
INTERVENTION ( S ) : None.
INTERVENTION ( S ) : None.
INTERVENTION ( S ) : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : None.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTIONS : Not applicable.
INTERVENTION ( S ) : @number@ sides were reviewed in @number@ CT scans.
Interventions occurred at four 1-week intervals.
INTERVENTIONS : Oral DHEA supplement with or without concomitant exercise.
INTERVENTIONS : Participants received @number@ hours of constraint-induced movement therapy ( CIMT ) , robot-assisted therapy , or mirror therapy ( MT ) .
Interventions : Participants were randomized in a 1 : 1 ratio to receive either @number@ daily dietary supplementation capsules or placebo for @number@ months.
Interventions : Participants were randomized to either placebo or testosterone gel for @number@ weeks ( TAP ) or @number@ months ( TEAAM ) .
Interventions : Participants were randomized to vitamin E , selenium , vitamin E and selenium , or placebo.
INTERVENTIONS : Patients were randomized 1 : 1 to enteric-coated aspirin @number@ mg / d or no aspirin in addition to ongoing medications.
INTERVENTIONS : Prior to IVA treatment , all patients received routine hormonal treatments with no follicle development.
INTERVENTIONS : RA.
INTERVENTIONS : Random assignment to maintenance antidepressant pharmacotherapy and donepezil or to maintenance antidepressant pharmacotherapy and placebo.
INTERVENTIONS : Screening colonoscopy with the removal of advanced colorectal neoplasms.
INTERVENTIONS : Self-reported use of calcium supplements.
INTERVENTION ( S ) : Serum AMH measurement.
INTERVENTIONS : Seventeen hours of group and individual training.
Interventions should address fear of falling among the frail seniors.
Interventions should address maintenance of preferred activities and adoption of new , fulfilling activities.
Interventions should aim to create a balance among activities in everyday life.
Interventions should aim to increase the proportion of testosterone recipients who have a valid indication.
Interventions should be developed to optimize prescribing for residents at increased risk of receiving medications with anticholinergic properties.
Interventions should include appropriate design of information materials , provision of alternative support , and increased one-on-one interaction with health care professionals.
INTERVENTION ( S ) : Skin wrinkles were assessed at @number@ locations on the face and neck using the Lemperle wrinkle scale.
INTERVENTIONS : Sleep deprivation.
INTERVENTIONS : Sleep exposure outcomes were measured using the Berlin Questionnaire to quantify sleep apnea and the Epworth Sleepiness Scale to measure daytime sleepiness.
INTERVENTIONS : Standardized IVF protocols.
INTERVENTION ( S ) : Standard stimulation protocol with gonadotropins and gonadotropin releasing hormone ( GnRH ) antagonist.
INTERVENTIONS : Statin therapy was withdrawn from eligible patients who were randomized to the discontinuation group.
Interventions studied included printed information or structured family conferences , with or without additional family support.
INTERVENTION ( S ) : Subjects underwent a pelvic ultrasound documenting ovarian volume and maximum follicle number in a single plane.
Interventions such as home safety assessment and preventive measures should be implemented to improve older adult's functional capacity and quality of life to prevent injury.
Interventions suggested by stakeholders included health service outreach , lifestyle counseling , community monitoring of healthcare and engagement activities.
INTERVENTIONS : Sun-Salutation B was performed , for eight minutes , at a high speed versus and a standard-speed separately while oxygen consumption was recorded.
Interventions : Supervised exercise consisted of treadmill exercise @number@ times weekly for @number@ months.
Interventions taking into account older bisexuals ' unique risk and protective factors may be helpful in reducing health inequities.
Interventions targeted toward the SORL1 amyloid risk pathway may be of greatest value during early phases of the lifespan.
Interventions targeting cognitive maintenance may benefit from increased focus on factors associated with continued social engagement.
Interventions targeting early stages of atherosclerosis may modify cognitive aging.
Interventions targeting multiple CRFs in younger-old people may help in maintaining mobility function.
Interventions targeting PAD in persons free of manifest cardiovascular and cerebrovascular disease may reduce the incidence of cognitive impairment and dementia.
Interventions targeting psychosocial mechanisms such as social and mental engagement and self-esteem offer potentially valuable opportunities to improve health outcomes and promote successful ageing.
Interventions targeting smoking and insulin resistance could curtail the undue advancement of reproductive aging.
Interventions targeting social participation should consider the potential impact of resilience on improving community belonging.
Interventions targeting these pathways should be evaluated to determine the impact on prevention or reversal of frailty among HIV-infected men.
Interventions : Testosterone gel , adjusted to maintain the testosterone level within the normal range for young men , or placebo gel for @number@ year.
Interventions : Testosterone gel ( adjusted to maintain the testosterone level within the normal range for young men ) or placebo gel for @number@ year.
Interventions : Testosterone gel , the dose adjusted to maintain the testosterone levels normal for young men , or placebo gel for @number@ months.
Interventions that bolster mitochondrial health and / or stimulate mitophagy may therefore forestall the neurodegenerative process in AD.
Interventions that build personal capacity , coping skills , and social support may contribute to better management of HIV / AIDS and increase HRQoL.
Interventions that either delay the onset of frailty or attenuate its severity potentially have cascading benefits for older people , their families and society.
Interventions that have been used across different scenarios to reduce the extent of thymic atrophy and enhance its output are discussed.
Interventions that include family units should be considered when possible.
Interventions that modify abnormal foot posture and function may therefore have a role in the prevention and treatment of foot pain.
Interventions that modify foot function , such as orthoses , may therefore have a role in the prevention and treatment of low back pain.
Interventions that reduce malaria during pregnancy may translate into a lower risk of postpartum infection.
Interventions that targeted elderly persons reporting poor balance confidence and / or those at risk for falls seemed more likely to be beneficial.
Interventions that target modifiable risk factors have the potential to improve risk profiles for periodontitis as well as for other common chronic diseases.
INTERVENTIONS : The 6-month intervention , the Home-based Post-Hip Fracture Rehabilitation , is a functionally oriented , home-based exercise program.
INTERVENTIONS : The anesthesia protocol was standardized for all study patients.
INTERVENTION ( S ) : The CpG methyaltion pattern of the promoter of CREM was examined using pyrosequencing.
INTERVENTIONS : The @number@ interventions included a task-oriented motor learning and a standard exercise program ; both interventions included strength training.
Interventions : The participants were randomly assigned to either the propranolol group or the steroid group.
INTERVENTIONS : There were no interventions.
INTERVENTIONS : The young patient was treated with continuous subcutaneous insulin infusion and blood glucose monitoring , and then transferred to oral acarbose therapy.
Interventions to address causes of cognitive dysfunction in this population may decrease demand for social services.
Interventions to be evaluated could include household crowding reduction and eradication therapy for asymptomatic infected persons to reduce their risk of noncardia stomach cancer.
Interventions to correct these phenotypes restore sensitivity to the mTORC1 signaling pathway and cause death , indicating that persistent signaling supports senescent cell survival.
Interventions to decrease unhealthy alcohol consumption may improve depressive symptoms.
Interventions to improve body composition in late life are crucial to maintaining independence.
Interventions to improve interactive health literacy focus on training consumers / patients in question preparation and asking.
Interventions to improve mitochondrial function have been shown to correct insulin metabolic signaling and other metabolic and cardiovascular abnormalities.
Interventions to improve self-management abilities may help older people age healthfully and prevent losses as they age further.
Interventions to improve sexual outcomes in women are limited.
Interventions to improve the cognitive health of older adults are of critical importance.
Interventions to increase potassium intakes alongside sodium reduction initiatives may be warranted.
Interventions to increase the social involvement of lonely individuals may improve well-being and lengthen life.
Interventions to manage chronic conditions associated with aging may have a significant impact on quality of life in older persons with HIV infection.
Interventions to prevent or alleviate depression should incorporate these differences.
Interventions to prevent or delay frailty in this population are highly recommended and can focus on health characteristics of the least frail group.
Interventions to reduce depressive symptoms in these populations should include strategies to change some of these modifiable risk factors.
Interventions to reduce literacy disparities in health care should minimize the cognitive burden in behaviors patients must adopt to manage personal health.
Interventions to reduce mortality and disability among patients with heightened vulnerability should be developed and tested.
Interventions to reduce sedentary behavior and increase activity are highly desirable and should take into consideration the temporality of homemakers and EW activity patterns.
Interventions to selectively target changes associated with the senescence process seem promising therapeutic strategies to improve transplantation outcome.
Interventions to support survivors should be a high priority.
Intervention strategies included staff training , resources , incentives , follow-up support , and performance monitoring and feedback.
Intervention studies have relied on cognitive training programs to promote adaptation and compensatory plasticity processes.
Intervention studies need a panel of measures which capture key features of healthy ageing.
Intervention study is needed to reduce recurrent falls through management of urinary incontinence.
INTERVENTION : Subjects were asked to incorporate either a 45-g whey protein or isocaloric maltodextrin supplement into their usual diet for @number@ months.
INTERVENTION ( S ) : Urinary triclosan concentrations quantified by online solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry.
INTERVENTION ( S ) : Video head impulse testing was performed , and compensatory saccades and horizontal vestibulo-ocular reflex ( VOR ) gain were measured.
INTERVENTIONS : We collected blood samples and performed HR-pQCT at the distal radius and distal tibia.
Interventions were classified as those directly aimed at increasing balance confidence or not , and further stratified into those using monofactorial or multifactorial approaches.
Interventions were conducted in 90-minute sessions twice weekly for @number@ weeks.
Interventions were identified and compared among different studies to explore the possibility of performing a meta-analysis , using complete ulcer healing as the outcome measure.
Interventions were personalized and delivered in home for a minimum of @number@ weeks.
Interventions will be ranked according to their effectiveness using surface under the cumulative ranking curve ( SUCRA ) .
Interventions with a longer duration and follow-up are needed to assess the timing and sustainability of the intervention effect.
INTERVENTION : Task-oriented visual feedback balance training.
INTERVENTION : The 6-weeks programme consisted of @number@ group sessions , with each session lasting for @number@ hours.
INTERVENTION : The Illumina HumanHap 650Y chip for genotyping.
INTERVENTION : The intervention group was stroke survivors using self-financed short-term residential care for stroke rehabilitation.
INTERVENTION : The intervention program was structured with the aim of simultaneously promoting better balance and frontal cognitive capacity.
INTERVENTION : The intervention strategy was the assignment of a LGIMD or a control diet.
INTERVENTION : The introduction of volunteer mealtime assistants to one ward to help patients during weekday lunchtimes in the intervention year.
INTERVENTION : The non-dominant arm was immobilised in a sling for a period of nine waking hours a day over two continuous weeks.
INTERVENTION : The non-dominant arm was immobilised in a sling for a period of nine waking hours a day over two continuous weeks.
INTERVENTION : The participants were randomly assigned to guar gum ( semi-fluid food with @number@ gram ) or placebo intervention during the first treatment phase.
INTERVENTION : The treatment group completed a 10-week twice-daily hip flexor stretching program that was supervised twice weekly by a rehabilitation clinician.
INTERVENTION : The treatment group completed a 10-week , twice-daily hip flexor stretching program , which was supervised twice weekly by a rehabilitation clinician.
INTERVENTION : Thirty-four young and @number@ older adults were randomly assigned to @number@ weeks of ET , RT , and control / CT.
INTERVENTION : This organizational form of care is characterized by a structured , systematic interdisciplinary CGA-based care at an acute elderly care unit.
INTERVENTION : Three-month daily meal service consisting of dinner and snacks ( intervention ) .
INTERVENTION : Three-weekly progressive ergometer-cycling sessions for @number@ weeks.
Intervention training and implementation were initiated on @date@ using corporate infrastructures for new program roll-out guided by standardized training elements designed by the research team.
INTERVENTION : Twelve-week LBPP-supported low-load treadmill walking regimen.
INTERVENTION : Twenty-four weeks of a twice-weekly community-based MTS program in combination with a standardized multicomponent exercise program.
INTERVENTION : V and EV groups were received vitamin E at a dose of @number@ IU / day P.O. for @number@ months.
INTERVENTION : Video head impulse test in the lateral semicircular canal plane.
Intervention wards will be supported to develop and implement locally tailored strategies to enhance early mobility , nutrition , and meaningful activities.
Intervention with glatiramer acetate is appropriate for RRMS.
Intervertebral disc degeneration was graded on a 0-5 scale according to the Pfirrmann classification.
Intervertebral disc ( IVD ) degeneration is a common degenerative disease , yet much is unknown about the mechanisms during its pathogenesis.
Intervertebral disc ( IVD ) disorders are a major contributor to disability and societal health care costs.
Intervertebral disk ( IVD ) degeneration is a natural progression of the aging process.
Interview coding using grounded theory led to two overarching categories from which motivation for mutual caregiving could be understood.
Interview data was gathered on sociodemographic , health-related and lifestyle factors referring to the last year.
Interviewees were asked about their beliefs and experiences related to osteoporosis and osteoporosis treatment.
Interviewer-administered surveys were conducted to collect data on walking and sociodemographics.
Interviews also assessed beliefs about obligation to support parents and grown children and rewards from helping.
Interviews and naturalistic observations were used over the course of 6months.
Interviews continued until saturation of content was reached.
Interviews elicited perspectives on ethical priorities and ethical challenges.
Interviews elicited the @number@ domains of men's explanatory model ( Kleinman , @number@ ) and open-ended information regarding men's experiences living with this disorder.
Interviews explored their journeys to and through mental health , aged care , primary care and social care services.
Interviews found that all participants encountered adults who are incapacitated and without surrogates.
Interviews provided consumer and counselor perspectives on the components of successful case closure ( employed ) and the impact of aging and disability on employment.
Interviews were analyzed to investigate \ "SOC talk , \ " that is , older people's talk about SOC behaviors in everyday life.
Interviews were analyzed using constant comparisons within and across interviews.
Interviews were analyzed using quantitative and qualitative methods.
Interviews were audio- and video-recorded and then transcribed.
Interviews were audiotaped and subsequently transcribed.
Interviews were conducted between @date@ and @date@ .
Interviews were conducted with @number@ pre- , peri- , and post-menopausal women aged @number@ to @number@
Interviews were conducted with @number@ senior plastic surgeons to determine why plastic surgeons choose not to retire.
Interviews were conducted with @number@ Western Australians aged @number@ + years to discuss food shopping in the context of their day-to-day lives.
Interviews were digitally recorded , transcribed verbatim and subjected to qualitative content analysis.
Interviews were enriched through the use of stimulus materials that included the demonstration of a prototype LDC health management web / mobile app.
Interviews were held with a wide range of informants , including company leadership , supervisors , and older workers.
Interviews were recorded and transcribed ; key themes were identified using qualitative analysis.
Interviews were transcribed and analysed by a coding team , applying the concept of illness coherence from the Common Sense Model of Self-Regulation.
Interviews were transcribed and analyzed using qualitative content analysis.
Interviews were transcribed and coded , then charted according to emergent themes.
Interviews were transcribed , coded , and analyzed for themes according to race or ethnic background.
Interviews were transcribed , coded , and a thematic analysis was conducted using a qualitative software package.
Interviews were transcribed verbatim while key points and quotes were taken from FGs.
Interviews with @number@ cat owners were performed to generate items.
Interviews with @number@ self-identifying sufferers explore the physical , emotional , behavioral and spatial manifestations of their condition.
Interviews with program staff were guided by the Diffusion of Innovations theory.
Interviews with three elderly people , from @number@ to @number@ years-old , were held from @date@ to July'@number@
Interview transcripts , back translated , were analyzed using N6.
Interview transcripts were analyzed through directed and summative content analysis employing the Ecological Model framework.
Interview transcripts were analyzed using Thorne's interpretive description approach.
Interview transcripts were coded and analyzed to identify key themes.
Intestinal changes were seen independent of dietary influences and aging within a consistent environment appears to avoid major microbiome shifts.
Intestinal injury is more difficult to diagnose and treat than upper GI damage , and symptoms correlate poorly with the severity of tissue injury.
Intestinal temperature ( T in ) and heart rate were recorded every @number@ km.
Intestinal tissues from patients with ulcerative colitis expressed significantly lower levels of SIRT1 mRNA than controls.
In TG mice decreased IL-6 in serum and lower p66shc in the liver were observed.
In that , different dimensions of material and social well-being , and abuse of people of the age @number@ and above , are assessed.
In that element , a MYB-binding site ( MBS ) was uncovered by transcription analysis.
In that regard the ICD is simultaneously a technology of life extension and dying.
In that sense , both protagonists experience aging as a time in which they are increasingly freed from social and family constraints.
In that study , @number@ participants were observed beginning in @number@ through @number@ when they were in their mid-20s , and continuing through @number@
In the 1960s , legislation was passed in Japan that implemented emergency medical services , and emergency hospitals were designated by the government.
In the 1990s , estrogens were thought to protect the aging brain.
In the 1990s , however , mortality rates decreased for these countries , an outcome related to early detection of the disease.
In the 2000s the mortality rates declined for all cancers except skin melanoma and female lung cancer , for which the mortality was almost stable.
In the 2050s , the ARR for the general population is @percent@ , based on temperature projections under RCP @number@
In the 3rd decade , there was a dramatic increase in focal sclerosing glomerulosclerosis.
In the 3xTgAD brain , utilization of ketone bodies as an alternative fuel was evident at the earliest age investigated and declined thereafter.
In the 8 ( th ) and 10 ( th ) passage , the cell activity increased.
In the abdomen , about @time@ ridges were distributed in a plateau.
In the abdominal wall , CaHA diluted 1 : 4 with saline solution was injected subdermally using a linear-threading technique.
In the absence of a criterion standard , predictive value could not be calculated.
In the absence of active HIV replication , ongoing inflammation or other stressors suppress PGRN production from macrophages / microglia contributing to neurocognitive dysfunction.
In the absence of a cure for Parkinson's disease , development of preventive medications for this devastating disease is particularly encouraged.
In the absence of a functional UPP , small aggregate prone , cataractous lenses are formed.
In the absence of any recommendations , individual screening should be proposed to LTRs.
In the absence of any specific cause , a diagnosis of senile pruritus is proposed , suggesting that itch is secondary to ageing.
In the absence of careful preparation , electrodes can drift from their original location over the course of a tDCS session.
In the absence of catalase , neither the Japanese , or Hungarian acatalasemics nor acatalasemic mice had significantly increased blood glutathione peroxidase activity.
In the absence of changes in social support as manifested by marital status and community living , there was no decline in wellbeing.
In the absence of dexamethasone , DHJST did activate SMAD @date@ and ERK signaling and hence increased RUNX2 protein expression in hMSCs.
In the absence of direct non-invasive biomarkers of brain oxidative stress , iron accumulation estimated in vivo may serve as its proxy indicator.
In the absence of human clinical trials , evidence for a role of RES on bone heath relies on evidence generated by animal studies.
In the absence of neurodegeneration , GLaz loss-of-function increases Atg8a / LC3 mRNA and p62 protein levels without altering p62 mRNA levels.
In the absence of Pin1 , APP is processed into toxic beta-amyloid and tau becomes misshapen to form tangles.
In the absence of regulation , there has been significant variation in the interpretation and implementation of these provisions among States.
In the absence of retrieval mode , neither type of studied item elicited ERP correlates of familiarity-based retrieval ( FN400 ) .
In the absence of senescence , juveniles would be the most susceptible age class.
In the absence of tBregs , 4T1 tumors cannot metastasize into the lungs efficiently due to poor Treg conversion.
In the absence of trust , family members reported that goals of care discussions were ignored by staff or created confusion.
In the access trials , flankers were either ahead of the current target or unrelated.
In the ACS cohorts , both the genetic instrumental variable and observational ORs showed a null association with MVE.
In the acute form , cervicofacial disease can manifest with soft-tissue swelling , a painful pyogenic abscess , or a mass lesion.
In the AD group , women were less likely to initiate PIMs than men.
In the adjusted Cox regression analysis , FT₃ was a significant predictor of CV mortality ( @number@ @number@.63-0.91 ; P = @number@ ) .
In the adult brain , neurogenesis under physiological conditions occurs in the subventricular zone and in the dentate gyrus.
In the adult cerebral cortex IGF-1 only affects oligodendrogenesis.
In the adult mouse brain , newly born Sema5A- / - GCs show an increase in dendritic spine density and increased AMPA-type synaptic responses.
In the adult population , liver measurements varied with gender.
In the age composition of advanced schistosomiasis patients , the greatest number of cases was in the 60-70 years age group ( @percent@ ) .
In the aged group , @number@ genes were modulated , whose @number@ were also modulated in the young group.
In the aged skeletal muscle tissue , the number of satellite cells or motor neurons decrease and the function of the neuro-muscular junction declines.
In the ageing men , TLB and LELB T-scores were @number@ ( @number@ ) and @number@ ( @number@ ) .
In the aging brain , then one of the two enzymes involved in degrading synaptic amines , catechol-O-methyl transferase , increasingly catalyzes methylation processes.
In the aging heart , the shift in macrophage phenotype to a proinflammatory subtype leads to inflammaging.
In the aging lung , the lung capacity decreases even in the absence of diseases.
In the aging patient however a defunctionalized bladder can be discussed.
In the aging process , the distributions of patterns ( SE ) remain similar to young subjects.
In the aging process , upper periorbits can be divided broadly into two groups.
In the aging retina , inflammation plays a major role and causes adverse effects.
In the aging testing , the MIC-Key devices had a lifespan of @number@ ± @number@ h and the MINI survived for @number@ ± @number@ h.
In the aging , these recommendations are irregularly followed.
In the aligned condition , no visual preference was found at any group age.
In the all sample , cognitive functions correlated with [ Formula : see text ] peak , CI max and cerebral oxygenation-perfusion.
In the aMCI group , higher scores on MMSE , verbal and non-verbal memory and visuospatial tests were significantly related to better olfactory identification ability.
In the a-MCI group , only DHA concentrations and the ratio of n3 / n6 were significantly lower.
In the analysis , participants were classified into poor , moderate , or good functional vision groups.
In the analysis , supply and demand of medical care have to be distinguished.
In the analyzed samples , the association between TH01 and longevity was not replicated.
In the Anglo-Saxon scientific literature , successful aging has been consolidated during the last four decades.
In the animal study , the Rejuran® group showed similar durability and inflammatory response to the Yvoire® group.
In the ANOVA and regression models , age and gender were predictors ( p < @number@ ) .
In the arterial system , endothelial cells are both the source and target of factors contributing to atherosclerosis.
In the arterial wall nitric oxide ( NO ) is the key transmitter for endothelium-dependent regulation of vascular tone.
In the article , algorithm for maintenance of autonomy in older persons made by the authors is presented.
In the atherosclerotic plaques , amyloid deposition increases with aging.
In the base case , this improvement was assumed to be @percent@.
In the baseline investigations in the Danube Hospital , @number@ individuals took part and were examined completely at baseline.
In the baseline unrestricted life-space group , @percent@ ( n = @number@ ) had restricted life-space at 90-day follow-up.
In the beginning , the sequence of GPS data is segmented in time frame , and represented in vector form for data reduction.
In the best fitting model , the heritability estimates are @number@ for the MEQ and @number@ for the CES-D.
In the birth cohort , autism risk increased monotonically with increasing paternal age.
In the body , estrogen protects against adiposity , insulin resistance , and type II diabetes , and regulates energy intake and expenditure.
In the brain , 11βHSD1 is a potential therapeutic target implicated in age-associated cognitive dysfunction.
In the brain , 11β-hydroxysteroid dehydrogenase type @number@ ( 11β-HSD1 ) amplifies intracellular glucocorticoid levels.
In the brain , intracellular iron is essential for cellular metabolism.
In the brain , it contributes to synapse formation , axonal remodeling , dendrite outgrowth , synaptic activity , neurogenesis and behavioral plasticity.
In the brains of people with AD , Pin1 is absent or inactivated and cis tau is accumulated at early stages of AD.
In the brain , they are involved in development and synaptic plasticity.
In the broadest context , biological markers , or biomarkers , are molecules that characterize a biological system or process.
In the C57BL / 6 background , both the expression of the mutant ferritin and the iron levels were lower than in the FVB strain.
In the cadence and stride length conditions , only @percent@ and @percent@ of positive linear or quadratic relationships were R ( @number@ ) ≥0.90.
In the CAGI PGP challenge , researchers were asked to predict whether an individual had a particular trait or profile based on their whole genome.
In the canonical UPP , both ubiquitin and the 26S proteasome are involved.
In the cardiovascular system , the macrocirculation and microcirculation two subsystems can be affected by aging.
In the CART analysis , age was the major discriminator at the first level ( at age @number@ ) .
In the case of alkaline phosphatase , it is rarely considered that reference values change over life periods.
In the case of antagonistic pleioptropy , an increase in one of these parameters usually leads to a predictable decrease in the other.
In the case of atherosclerotic plaques , oxy-lipids trigger release of the pro-inflammatory cytokines and inflammation that activate calcification processes in aorta intimae.
In the case of excess use of antihypertension medications there is a big risk of developing arterial hypotension.
In the case of fasting glucose , lower cognitive functioning was only observed in the highest quintile.
In the case of incontinence due to prostatic disease anticholinergic drugs usually worsen the problem.
In the case of indoor moisture / mold damages , everyone can be affected by odor effects and / or impairment of well-being.
In the case of mUPD , almost all individuals with histories of psychopathology suffered from psychotic symptoms ( @percent@ ) with or without affective component.
In the case of ( @number@ ) F-FDG , dosimetry calculations of reference paediatric patients from various dose regimens were also calculated.
In the case of resorbable / semi-permanent fillers , more studies are needed before recommending antibiotic therapy.
In the case of the skin the differential targeting of estrogen receptors to promote healing in aged subjects is a real therapeutic possibility.
In the CASTEL cohort , systolic BP was higher in women.
In the central nervous system , cholinergic and dopaminergic ( DA ) neurons are among the cells most susceptible to the deleterious effects of age.
In the central nervous system ( CNS ) , microglial cells are likely the main source of ROS production.
In the central nervous system , senescence and neurodegeneration occur as a consequence of mitochondrial oxidative insults and impaired electron transfer.
In the centrum semiovale ( CS ) , reduced FA correlated with visual memory ( p = 0.0622 ) .
In the cerebellum both internal granular cell layer and molecular cell layer showed a significant increase of 5hmC till adulthood.
In the cerebellum CSPalpha expression is upregulated to young , healthy levels and this may protect cerebellar synapses and neurons to survive.
In the cerebral cortex , synaptic-type , Kuru plaque-like , and coarse plaque-type PrP depositions were mainly observed , along with some perivacuolar-type PrP depositions.
In the cerebral cortices , neuronal and glial inclusions consist of abnormally aggregated proteins , such as tau or TDP-43 , which are disease-specific.
In the cervical segment of the spinal cord , SPP1 was principally expressed in choline motor neurons in lamina IX.
In the circumferential direction , the LS regions were the stiffest in the LCS and RCS , whereas NCS had relatively uniform stiffness.
In the Cisd2 knockout mice , Cisd2 deficiency shortens lifespan and drives a panel of premature aging phenotypes.
In the clinical pattern of disease in the first @number@ hours , symptoms of heart failure prevailed.
In the CNS , rapamycin shows beneficial effects in neuronal survival and plasticity , thus contributing to memory improvement.
In the coarse range , accuracy decreased slightly with disparity and there were no differences as a function of age.
In the combined Asian data sets , SNPs @number@ and @number@ through @number@ were associated with AD risk ( P < @number@ ) .
In the combined database , the \ "at risk \ " group had a prevalence of @percent@.
In the combined study group , increasing weight was associated with less skin wrinkling.
In the coming decades , hospitalizations and deaths associated with Salmonella in seniors could represent a challenge due to an aging population in Canada.
In the community-based Vietnam Era Twin Study of Aging , @number@ male twins completed two days of cortisol saliva sampling in their natural environments.
In the community-dwelling elderly , serum Hsp70 and IL-10 concentrations were significantly lower and IL-6 was significantly higher when compared to healthy young control subjects.
In the company studied , only @percent@ of workstations met the noise standards and @percent@ of workstations met the lighting standards.
In the comparison of the kinds of institutions , immigrants are less likely to access outpatient hospice services compared to PC.
In the CONCLUSIONS : Self-reported frequent sleep disturbance in middle-aged men may relate to the development of dementia in later life.
In the CON group , performance on EF tasks did not predict adaptive scores over the influence of age.
In the context of aging , this theory raises interesting questions , given that the motivations of older adults differ from those of younger adults.
In the context of blood pressure regulation , both central and peripheral hormonal influences are important as well.
In the context of plaque progression , platelet hyperactivity associated with hyperlipidemia contributes to the development of a pro-thrombotic state.
In the context of previous work , our findings suggest that the aging brain may also be characterized by additional measures besides chronological age.
In the context of social construction , sexuality is a subject that should be examined in greater depth.
In the contingent condition , attentional capture appeared independent of age and persisted over the stimulus-onset asynchronies but was markedly pronounced for elderly people.
In the control cases , small but significant amounts of ubiquitin- and p62-positive intranuclear structures were found.
In the control condition , older and younger adults ' memories were comparably episodic , but older adults recalled more semantic details.
In the control conditions participants were either instructed to focus on visual information or not provided any specific orientation instruction.
In the control group , 174537T carriers had significantly lower levels of total- and LDL-cholesterol , malondialdehyde , and ox-LDL.
In the control group , an age-related decline in glucose uptake was found only in the cingulate cortex.
In the control group , conventional semen parameters as well as DNA fragmentation and chromosomal abnormalities did not show a statistically significant with age.
In the control group , five subjects were treated with HA filler alone.
In the control group , prediabetes was diagnosed in @percent@ of patients.
In the control group , serum free T4 and TSH levels were not associated with any of the assessed cognitive domains.
In the control group , two patients presented minimal ecchymosis and three slight hematoma.
In the conventional view , aging of the brain is associated with atrophy vascular abnormalities and loss of volume in hippocampus and amygdala.
In the COPD and dementia groups , @percent@ and @percent@ , respectively , were above the cut-off point for psychiatric caseness on the GHQ.
In the course of the transformation of a normal cell to a cancerous cell , senescence is frequently induced to suppress tumor development.
In the covariate analysis , linear functions , power functions , and a power function with a bodyweight-dependent exponent were tested.
In the crosslink sites of the collagen molecules , the main ratio of fluorescence is found.
In the cross sectional analyses ( based on @number@ individuals ) , we identified @number@ twins with PD and @number@ twins with parkinsonism.
In the cross-sectional analysis the correlations between the knee extension strength and BMD of the two regions were examined , using Pearson's correlation coefficient.
In the cross-sectional analysis we calculated the level of physical activity and the prevalence of poor or moderate work ability as reported by the participants.
In the cross-sectional study , plasma Klotho concentrations positively correlated with carotid artery compliance and VT and negatively correlated with the β-stiffness index.
In the cross-sectional study , serum C1q level increased with aging and was negatively correlated with muscle mass and strength.
In the Cuban elderly , the final design shows that , with the exception of WHR , all indicators were associated with hypertension.
In the current article we provide an overview of the design of the frailty index and its relation with adverse health outcomes.
In the current era of aging workforce and skill shortages , implicit measures may be necessary to illuminate hidden workplace ageism.
In the current precision medicine era , more and more samples get genotyped and sequenced.
In the current research , we tested whether stereotype threat can also benefit memory.
In the current review of the rodent literature , we present arguments that question the robustness of the paradigm to increase lifespan and healthspan.
In the current review , the specific modifications induced by carbonylation in protein structure and function in muscles have been described.
In the current series of studies , we investigated the influence of feedback valence on reinforcement learning in young and older adults.
In the current study , fecal samples were collected prior to bowel preparation from participants of screening colonoscopy in the German BliTz study.
In the current study information about normal sex- and age-related linear distances is provided.
In the current study , miR-107 was revealed to be downregulated in chronic myeloid leukemia cells.
In the current study , older adults simultaneously performed a verbal working memory and a cardiovascular training to improve cognitive and motor-cognitive dual task performance.
In the current study participants retrieved autobiographical memories during presentation of musical clips.
In the current study , the aim has been to investigate discourse macrolinguistic variability.
In the current study , the authors assessed the use of thyroidectomy and RAI among elderly patients with DTC and the effects on survival.
In the current study , we collected observational data to investigate predictors of the quality of grandmother-grandchild interactions in Zambia.
In the current study , we demonstrate that mitochondria were a major ROS source in EV71-infected cells.
In the current study , we examined the relationship between age-related changes in white matter and language production.
In the current study , we examined whether older adults show this same memory effect.
In the current study , we explore the effect of this polymorphism on EM-related activity and cognitive performance across the adult life span using fMRI.
In the current study , we investigated whether a partial reduction of Drp1 protect neurons from phosphorylated Tau-induced mitochondrial and synaptic toxicities in AD progression.
In the current study , we investigated whether the COMT Val158Met polymorphism predicts treatment response to VPA + add-on DM and to VPA + placebo.
In the current study , we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.
In the current study , we provide a better understanding of the chimpanzee immune system with regard to age and sex.
In the current study , we reviewed epidemiological findings regarding geriatric mental health in Korea.
In the current study , we show a new role of miR-17-92 in inhibiting oncogenic ras-induced senescence.
In the current study , we show that application of secreted AS alters membrane fluidity and increases calcium ( Ca2 + ) entry.
In the current study we sought to examine gene expression in the cerebral cortex during development in the context of this adaptive plasticity.
In the current study , we sought to understand the role sexual attitudes have on sexual well-being among middle-aged and young-old adults.
In the current study , we sought to understand the role sexual attitudes have on sexual well-being among middle-aged and young-old adults.
In the current study , we targeted plasminogen using PLL and assessed its anti-prion efficacy.
In the current study , we tested this hypothesis by having younger and older adults complete a verbal Sternberg task without interference manipulations.
In the current study , we used an LDL genetic risk score ( GRS ) to overcome this problem.
In the current study , we used electrointestinography ( EIG ) to measure intestinal activity of healthy humans at rest.
In the current study , we used microarray analysis to identify hepatic genes that changed with age.
In the deletion trials , flankers were previous target items.
In the derivation set , age and aspartate aminotransferase ( AST ) were independent clinical predictors of advanced fibrosis.
In the dermis , hTERT expression was present in some skin appendages.
In the developed countries , people are living longer and the number of aged persons is growing.
In the developed world , age-related macular degeneration ( AMD ) is one of the major causes of irreversible blindness in the elderly.
In the developing cochlea , electrical coupling , probed by dual patch-clamp recordings , was normal.
In the developing world , robust epidemiological estimates of fracture incidence are required to inform policy development.
In the diseased states , TDP-43 proteins exhibit characteristic alterations , including truncation , abnormal phosphorylation , and altered subcellular distribution.
In the DLB group , we found increased connectivity between the precuneus and regions in the dorsal attention network and the putamen.
In the DL-PDT group ( experimental group ) , @number@ treatments of the entire face are conducted over the course of @number@ months.
In the donor sites , the contours of the articular surface of the medial and lateral femoral trochleae were determined.
In the dual task condition , the association between WMHs and CSRT was mediated through slowed cognitive processing and not through reduced sensorimotor functioning.
In the early onset group , @number@ patient carrying homozygous APOEε4 had a novel heterozygous missense mutation in the PSEN2 gene ( p.T421M ) .
In the early stages of the disease , the patient exhibited gait disturbance with ataxia and dysarthria as well as gradual appearance of cognitive dysfunction.
In the early transition , estradiol was similar across tertiles of fat ; postmenopause , estradiol was positively associated with visceral fat.
In the elder group , filtering was associated with the bilateral insulae , right precuneus , and bilateral ventromedial prefrontal cortex.
In the elderly a large interindividual variability in drug disposition is particularly prominent.
In the elderly and in adults below the age of @number@ several studies have established a close association between vitamin D levels and neuromuscular coordination.
In the elderly assessment of renal function by glomerular filtration rate estimation is crucial for diagnostic , therapeutic and prognostic purposes.
In the elderly , asthma remains a clinical challenge.
In the elderly , both changes occur concurrently and it remains unclear the relative contribution on CHD risk.
In the elderly , degenerative changes in the lumbar spine are common , contributing to falsely elevated bone mineral density ( BMD ) values.
In the elderly endothelial dysfunction occurs as altered endothelial ability to regulate hemostasis , vascular tone and cell permeability.
In the elderly group functional activation was generally increased for all tasks with comparable motor performance for ipsilateral primary and secondary motor areas.
In the elderly head roll increased with perturbed vestibular information in impaired somatosensory condition ( by @percent@ ) .
In the elderly , it may reflect the neuronal loss caused by aging.
In the elderly , major complaints include dizziness and an increasing number of falls , possibly related to an altered processing of vestibular sensory input.
In the elderly , poor self-reported health status appears to be more strongly associated with depression than the presence of chronic disease.
In the elderly , systolic blood pressure increases because of arterial stiffness produced by structural alterations of arterial wall occurring with aging.
In the elderly , the increased cardiovascular demand during heat waves is often fatal because of increased strain on an already compromised left ventricle.
In the elderly , the main alteration in voiding is due to a higher prevalence of DO.
In the elderly , the rise in postprandial plasma triglyceride ( TG ) concentrations is increased , contributing to their increased risk of cardiovascular disease.
In the end , camouflage techniques using hair colorants are outlined.
In the end , only @number@ patient thought she was worsened after the treatment.
In the entire cohort , adjusting for relevant covariates , LM and FM were significant predictors of all BMD measures in both genders.
In the entire series , average volume of cement injected was @number@ cc / screw.
In the entire study population , FT3 under normal limits is effective in discriminating frail / prefrail subjects from nonfrail subjects.
In the era of personalized treatment , surgery is still one of the most important treatment modalities to combat lung cancer.
In the era of the development of systems biology , integrative approach is expected allowing a better understanding of the overall effects of RAGE system.
In the European Union , active ageing is monitored and promoted chiefly by the Active Ageing Index , a policy tool in use since @number@
In the event of a gait and / or balance disorders , it is recommended to prescribe physiotherapy.
In the event of death or reported hospitalization , hospitalizations were adjudicated according to medical record review.
In the experimental conditions with healthy young controls , @number@ trials were sufficient to measure the optimal FRN amplitude.
In the experimental group ( n = @number@ ) , microplates were affixed bilaterally across the zygomaticomaxillary and frontonasomaxillary sutures at @number@ months of age.
In the experimental group , the other five subjects were treated with intradermal RF prior to HA filler.
In the experimental group , the picture after therapy of the upper lip was more frequently chosen to be the younger-looking one by the panel.
In the experiment , surface electromyography ( sEMG ) was also measured as a reference to estimate muscle activity for comparison.
In the explants cultures from older babies this population was missing.
In the extreme case , even step adjustments appear to be further modifiable online , e.g. , when avoiding obstacles during tripping.
In the eye , choroidal neovascularization ( CNV ) causes blindness in patients with age-related macular degeneration ( AMD ) .
In the fall of @number@ she was the on-site psychologist for the reality show Survivor : The Australian Outback.
In the fall of @number@ the Government of Quebec set up a Public Consultation on Living Conditions of Seniors.
In the femoral shaft , cortical BMD decreased significantly ( @number@ ± @number@.188% / year , p < @number@ ) .
In the field of ADRs , drug-nutrient interactions ( DNIs ) are a relatively unexplored area.
In the field of frailty , there is an underlying hypothesis that chronic low-grade inflammation contributes to bad outcomes in response to a stressor.
In the fifty years since Békésy was awarded the Nobel Prize , cochlear physiology has blossomed.
In the final analytical phase , the critical attributes of old people with chronic diseases were investigated.
In the final mixed-effects models , arteriolosclerosis , myelin pallor , and Braak score remained significantly associated with increased WMH accumulation over time.
In the final model , age , male sex , and long-term-care facility admission were significant factors.
In the final model , comorbidity , diabetes mellitus with complications , depressive symptoms , and cognitive impairment were significant independent risk factors for mortality.
In the final model , the parameter values were standardized for a body weight of @number@ kg using an allometric model.
In the final multivariate model , after adjusting for covariates , Alzheimer's medication use ( p = @number@ ) was associated with hazard of fall.
In the final sample ( @number@ articles ) a total of @number@ biomarkers were detected.
In the fine range , accuracy was constant across all disparities in adults and increased with disparity in children of all ages.
In the first condition , participants were not made aware of their motor overflow.
In the first experiment , performance with the game controller was associated with fewer tracking errors.
In the first experiment ( sex identification ) adults were asked to categorise the voice as either male or female.
In the first experiment the isolated item was the word \ "table \ " in a list of fish names.
In the first experiment , the synchrony judgments were recorded for varying intermodal time differences in audiovisual sentence recordings.
In the first extract the audio-recorded transcript was examined for events of institutional talk and rephrasing of questionnaire questions.
In the first family , a nonsense mutation , c.2313T > A , leading to a truncated protein ( p.Y771X ) was identified.
In the first group , we obtained the discriminative patterns using a t-test filter and sparse representation step.
In the first months of life , the EEG of anaesthesia is less differentiated , but it is still useful in patient monitoring during anaesthesia.
In the first @number@ ms , ERP inhibition research has primarily focused on N1 and P1 as the ERP components associated with inhibition.
In the first @number@ years of cell culture , the development of new cell lines was mainly based on trial and error.
In the first of two studies , we examined the sexual and violent recidivism of @number@ sex offenders who were over age @number@ on release.
In the first part of this introduction the basic biology of fracture healing is presented.
In the first phase , each cognitive task was defined at three difficulty levels , and perceived difficulty was compared across tasks.
In the first phase , OXPHOS is decreased because of reduced expression of mitochondrially encoded genes.
In the first round , blind testing , consumers were served @number@ sample from each treatment , with no product information provided.
In the first stage , we estimate diffeomorphic shape trajectories for each individual that minimize inconsistencies in segmented shapes across time.
In the first study , data from the group of patients were used to determine the frailty state of a new incoming patient.
In the first study , we used dyadic interviews and photovoice techniques to examine experiences of people with early-stage dementia.
In the first task ( steady state F0 ) , the fundamental frequency difference limen ( F0DL ) was measured adaptively for synthetic vowel stimuli.
In the first two cases , teeth with cemental tear were extracted due to poor prognosis.
In the first volunteer , one of the disks was analyzed using a scanning electronic microscope.
In the first week , women were asked to monitor their daily steps ( baseline steps ) .
In the first years of his life , clinical features included delayed psychomotor development and ataxia.
In the foci of actinic keratosis , the expression of MMP-1 was observed in @percent@ of cases and that of MMP-9 was seen in @percent@.
In the follow-up of up to @number@ days , @percent@ of patients were free of MACCE and @percent@ were free of MACE.
In the follow-up study in 2005-2008 ( CRISPS-3 ) , @number@ out of the @number@ subjects had developed hypertension.
In the forearm , two MTs ( forearm-radius and forearm-ulna MT ) were measured.
In the forebrain CSPalpha expression is reduced early in the disease and this may contribute to the initial stages of synaptic degeneration.
In the foreseeable future , proteomic studies might predictably help identify novel associations between putative biomarkers and functional decline.
In the forestomach , there were significantly increased incidences of inflammation and epithelial hyperplasia in @number@ g / kg females.
In the former assay , sesquiterpenoids were more potent than diterpenoids.
In the fourth section the participants were asked about gender , age , and education.
In the frame of autologous MSC therapy , it is important to detect donor's parameters affecting MSC potency.
In the frontal white matter , increase in iron level was also associated with a decrease in MD and an increase in FA.
In the full model adjusting for socioeconomic and lifestyle factors , the association between generation ( but not acculturation ) and diabetes remained significant.
In the full sample , the intervention had no effect ( P = @number@ for intervention × time interaction ) .
In the full sample the strongest predictors of SMC were poor psychological well-being , depressive symptoms ( including those taking antidepressants ) and hearing impairment.
In the full-vision condition , visual feedback was available for the duration of the trial.
In the fully adjusted model , all conventionally significant ( p < @number@ ) effects were removed.
In the fully adjusted model , cognitive restraint , consumption of sweets , anxiety , and lack of depression were associated with OB-WC.
In the FungiScope registry , we identified @number@ children with disseminated fusariosis between @number@ and @number@
In the future , larger genetic studies specifically examining LLD , including non-hypothesis-driven GWAS , are required to further identify genetic determinants of LLD.
In the future measurements with the method should be extended to concern hard-to-heal wounds.
In the future , miRNAs may greatly contribute to stem cell clinical therapy and have potential applications in regenerative medicine.
In the future , more children will be exposed to cosmeceuticals and may experience side effects such as contact dermatitis and skin irritation.
In the future , more individually-tailored interventions are needed to overcome the factors that prevent exercise initiation.
In the future , sleep SWA assessments may be used as a clinical tool to detect aberrations in cortical maturation.
In the future , such advances will likely continue , although the pace of technological breakthroughs is difficult to predict.
In the future , the development of telematic communication systems will extend indications.
In the future the lack of data in the migrant population will again rise due to unregistered remigration.
In the future , there will be less caretaking , which is necessary to support the aging population.
In the future , these cells may be applied in cell therapy to replace or regenerate tissues by autologous transplantation.
In the future this may be relevant to genetic testing and counselling of patients with PD and their families.
In the future , this test could be utilized to evaluate the contributions of sensory deficits to motor recovery following stroke.
In the future vascular medicine will still have a great impact on health of people.
In the gastrocnemius , there were no significant changes to muscle thickness or pennation angle over @number@ or @number@ days.
In the general population , @number@ men aged ≥ @number@ years died of prostate cancer , and aging was associated with increased risk.
In the general population , the number of comorbidities increases with aging.
In the general population , the prevalence of undernutrition was @percent@.
In the GMFCS level IV-V group , there was an annual increase of @number@.4° in the scoliosis Cobb angle ( p = @number@ ) .
In the group above @number@ years , non-significantly higher neutrophils and eosinophils counts and CD4 / CD8 ratio were observed.
In the group of men , there were significant positive associations between alcohol intake , HbA1c and FPG-sensitive sites in multivariate analysis.
In the group of participants with AD , the Aβ1-42 levels were significantly lower in the APOEε4 carriers compared to the non-carriers.
In the group with DKA , c-peptide level was significantly lower than in the group without DKA ( p = @number@ )
In the gut microbiome of GE-treated humanized mice , there was an increase in abundance of genera Lactococcus and Eubacterium.
In the GWG model , a significant substantial @percent@ decrease in the coefficient was observed.
In the HDL fraction , paraoxonase activity was elevated by @percent@ along with elevation of apoA-I and cholesterol contents.
In the healthy controls , we found more head motion in men than in women and more motion with increasing age.
In the heart , mitophagy is an essential housekeeping process and required for cardiac homeostasis.
In the hierarchical regression analyses , education and computer knowledge significantly increased the explanatory power of the models.
In the highest slope ( PH , @percent@ ) , older adults reduced speed and step length and both groups increased cadence.
In the hippocampus , mGluR5 was more abundant in the CA3 region and co-localized with alpha-syn aggregates.
In the hippocampus of BACE1-null mice , we found a robust @percent@ decrease of Na ( v ) 1.1 levels.
In the hippocampus , there was a dramatic reduction in neurogenesis , whereas reactive microglial infiltrates revealed an inflammatory hippocampal state in the senile rats.
In the Hippo pathway , MST1 / 2 kinases together with the adaptor protein SAV phosphorylate LATS1 / 2 kinases.
In the Hold condition , the cue was either consistent or inconsistent with task instructions.
In the human body , it is estimated that cell division and metabolism occurs exuberantly until about @number@ years of age.
In the human lens , some sites were more prone to forming non-disulfide covalent cross-links than others.
In the human retina , a 32-fold increase of TF mRNA expression was detected in AMD macular lesions compared with normal maculae.
In the human study , rate of MP visualization by pCLE was evaluated as the primary outcome.
In the hypoxanthine-xanthine oxidase system , electron spin resonance showed that aged garlic extract scavenged superoxide radicals in a dose-dependent manner up to @percent@.
In the identification of levels of dependency results indicate us that @percent@ are independent and @percent@ are dependents , minimum being @percent@ total-dependent.
In the IFN-free DAA era , data showing similar SVR rates and safety profiles between the elderly and their counterparts have been demonstrated.
In the iliopsoas muscle , islands of isolated muscle fibres can be seen against a background of fatty tissue.
In the indirect tensile strength test differences in auto-polymerized and dual-cured specimens were only detected for RXU and DCM.
In the informal settlements of Mombasa , Kenya , the management of stress-associated with economic precariousness-plays a significant role in self-care practices and ideologies.
In the information search task , older adults performed worse than younger adults ( F ( @number@ ) = @number@ P < @number@ ) .
In the infra-umbilical region , CA was performed on the right and RF was performed on the left side.
In the interactions that followed among the support group participants , those positions were mainly affirmed.
In the interim , the process of catching old by living different is the ultimate , life enhancing skill.
In the intervening years , the average number of diagnoses per @number@ liquidator increased from @number@ in @number@ to 7-8 in the recent time.
In the interventional study , aerobic exercise training increased plasma Klotho concentrations and carotid artery compliance and decreased the β-stiffness index.
In the intervention homes , education for caregivers was provided and ultrasound baths for denture cleaning were implemented.
In the interviews the respondents were asked to give their opinions about a good old age and its constituents.
In the intestine , RIPK1 acts as a scaffold to prevent epithelial cell apoptosis and preserve tissue integrity.
In the intrinsically aged murine skin , K6EAA-L12 showed anti-ageing effects by activating collagen synthesis , eventually causing dermal thickening.
In the IPDGC analysis , none of the @number@ SNPs , including rs4911414 , were associated with PD risk after adjusting for multiple comparisons.
In their narratives , all parties shifted between these different relational positions as they managed hopes and expectations for the research project.
In their natural environments , cells are regularly exposed to oxidizing conditions that may lead to protein misfolding.
In the IV group , no cases of pregnancy were recorded.
In the language task , aging increased language-switching costs in both response times and errors , and language-mixing costs only in response times.
In the largest study to date , we established associations between CMV-IgG levels and multiple indicators of psychological stress.
In the last 10-15 years , strategies and modalities of lung cancer treatment have changed dramatically.
In the last decade , a large body of research has significantly improved our understanding of the genetic architecture of gene expression.
In the last decade evidence from different laboratories shows that memory T cells may share self-renewal pathways with bone marrow hematopoietic stem cells.
In the last decade , evidence has accumulated to support the association between cerebral vascular diseases ( CVD ) and AD.
In the last decade , PPVI has evolved as an alternative treatment option with much less morbidity compared to repeated surgery.
In the last decades , important progress has been made in understanding molecular mechanisms of photoaging.
In the last decades , the participation of elderly trained people in endurance events such as marathon running has dramatically increased.
In the last few decades , an increasing percentage of the population has become immunosuppressed.
In the last @number@ participants recruited , we made additional assessments of fatigue and ESAS both at baseline and @number@ month after discharge.
In the last @number@ years , amniotic fluid-derived stem ( AFS ) cells have been shown to express embryonic and adult stem cell markers.
In the last @number@ years the resident population of Portugal has increased @percent@ , along with a progressive ageing.
In the lasts years it has emerged a possible linkage between androgen deficiency and CVD.
In the last twenty years most developed countries face dramatic demographic changes , and predominantly the rapid aging of their population.
In the last year , attention has been focused on translating federally sponsored health research into better health for Americans.
In the last years , a significant improvement in life expectancy of HIV + patients has been observed in Western countries.
In the last years dramatic changes in clinical and epidemiological characteristics of patients admitted to cardiac intensive care units have been observed.
In the last years , there has been a rising interest to find an objective method to estimate listening effort.
In the lateral BTT , subjects @number@ to @number@ years of age exhibited tracking along the X-axis , with no observable tilt.
In the later course of the experiment modulations in frontal theta power became larger for older , compared to younger adults.
In the late seventies , a small tribal population of Paraguay , the Ache , living under natural conditions , was studied.
In the late stages of the disease , surgical interventions are often necessary to partially restore joint function.
In the latter case , adapted prescribing criteria should be developed and evaluated in those patients.
In the latter case , PCF was significantly associated only with MIP.
In the latter , our method is able to identify a minimal set of @number@ markers that accurately predict Behçet's disease and sarcoidosis.
In the latter , scarcity of hallucinations , especially if there are not well formed and detailed , should prompt 123I-FP-CIT SPECT.
In the left amygdala and hippocampus , local tissue volumes were significantly correlated with negative symptoms.
In the left coronary arteries of women , the Ca and P contents increased significantly and progressively with aging.
In the Leiden Longevity Study , middle-aged offspring of non-agenarian siblings and their partners as environmentally matched controls were included.
In the Leiden Longevity study , we recruited long-lived siblings and their offspring.
In the lens , the most abundant cross-link involved Cys5 of βA4 crystallin attached via a thioether bond to glutathione.
In the light of new perspectives , storage time is not the touchstone to rule on the quality of a packed RBC unit.
In the light of our results , MetS seems to play an important role in the etiopathogenesis of ED in patients with BPH.
In the limelight of clinical studies investigating glicentin variation in human , we discuss future directions for potential applications in clinical practice.
In the literature , non-ablative fractionated photothermolysis ( nFP ) is accredited with improvement of wrinkles and scars combined with a reduced downtime.
In the logistic models , U-shaped associations remained for SBP , DBP , and MAP but not PP.
In the logistic regression analyses , younger age , ADL dysfunction , and previous depression were significantly associated with higher CSDD scores.
In the logistic regression analysis , a significant odds ratio was obtained for the same items , excluding age.
In the longitudinal analyses ( based on @number@ individuals ) , we identified @number@ twins with PD and @number@ twins with Parkinsonism.
In the longitudinal analysis , cognitive decline became more rapid with increasing age.
In the longitudinal analysis , higher levels of VWF were associated with a steeper decline in CBF ( p = @number@ ) .
In the longitudinal analysis , none of our inflammatory biomarkers were associated with either depressive symptoms or cognitive decline.
In the longitudinal data , the only significant relationship was that between E1 and self-rated health.
In the longitudinal direction , the human AA regions were more compliant than all sinuses.
In the longitudinal study of CSF klotho , no significant circadian fluctuations were found in CSF klotho levels.
In the long-term , Mex elderly may be at greater risk for sarcopenic obesity compared to other ethnic groups.
In the low-emotion condition , on the other hand , both younger and older adults preferred to use alternative-based processing strategies.
In the lower level of the face , atrophy or osseous rotation may contribute to the signs and symptoms of facial aging.
In the lower limb , we determined the pennation angle to derive the fascicle length.
In the luteal phase , InhB decreased or became undetectable and did not demonstrate episodic secretion.
In the macula region of RPE / choroid segments from human eyes , the level of cystatin C protein was reduced with increasing donor age.
In the main study , @number@ subjects applied either a stabilized retinol formulation or its vehicle to the full face.
In the majority of cases , HS occurs in the setting of other degenerative changes , usually Alzheimer's disease ( AD ) .
In the majority of cases , strong risk factors are not identifiable.
In the majority of cases the site of ligature was below the hyoid bone and in only one on the hyoid body.
In the majority of subjects , the level of daily activities was high , which proves an independent functioning.
In the majority of the studies , development of neutralizing antibodies to botulinum toxin was considered responsible of the induced clinical resistance.
In the mammalian brain , p53 plays critical functions in normal development , tumor suppression , neurodegenerative diseases , and aging.
In them , apathy contributed to the perception of a diminished quality of life in various aspects of daily life.
In the mature group , MMP-1 expression was minimal compared to the newborn group.
In the MCI subjects , the follow-up EEG recordings showed a decreased power of posterior alpha1 and alpha2 sources.
In the meantime , doubts have arisen about the value of these questionnaires.
In the meantime , the MYCN mRNA level and the secretion of TNF- α were inhibited.
In the medial half it was less distinct due to the deposition of iron and the interdigitation of white matter and the substantia nigra.
In the medial side of the forearm , @time@ ridges were distributed in a plateau , on average.
In the microtopography the glands have been proximal-distal changes ; the quantity of glands increase from the proximal to distal portion.
In the midbrain , white matter volume was observed to decrease with increasing fatigue duration.
In the middle-aged cohort a developing pattern was more likely for women than men.
In the middle-aged participants motor chunks as well as explicit sequence knowledge appeared to be less developed than in the young adults.
In the middle-age men , the metabolic syndrome had a significant negative correlation with storage symptoms ( odds ratio @number@.258-0.426 ) .
In the ML direction , MS2 had a higher MoS than HC ( p < 0.001 ) at heel strike only.
In the ML direction , older adults took up to 30s to regain balance.
In the ML direction , slow walking causes lower MoS at midstance , so PwMS increase their MoS by taking wider steps.
In the models including both functional ability and mobility factors , the importance of functional ability remained for mental but not for physical HRQoL.
In the modern medical era , more diverse and effective treatment options have translated to increased life expectancy.
In the more intelligent young adults , this relationship reverses so that by the age of @number@ a thicker cortex is associated with higher intelligence.
In the mouse , Crim1 is a growth-factor-binding protein with pleiotropic roles in the development of multiple organs , including the eye.
In the mouse hindlimb ischemia model , anti-miR-200c treatment rescued these targets and improved limb perfusion.
In the mouse liver , we observed increased age-associated localization of mH2A to regions of pericentromeric heterochromatin.
In the mouse model of carrageenan-induced paw arthritis , PEP-1-FK506BP12 suppressed both carrageenan-induced MMP-13 production and paw inflammation.
In the multiple correspondence analysis the main discriminant item was outside versus inside falls.
In the multiple regression analysis , most cases exhibited increasing ORs for dementia with increasing polypharmacy levels.
In the multiple regression analysis , the only factor associated with poor sexual function was being @number@ years of age or more.
In the multivariable model , engaging in a @number@ hS , self-reported stress , and age were independently associated with higher IL-8 levels.
In the multivariable regression model accelerometry was the only consistent independent predictor of VO ( 2peak ) ( p = @number@ ) .
In the multivariate analysis adjusted for potential confounders , no significant association was noted between the highest B2M quartile and incident frailty.
In the multivariate analysis , only COPD infectious exacerbation was independently associated with prolonged hospitalization ( P = 0.003 ) .
In the multivariate analysis , only two instruments indicated a significant association between anticholinergic load and all four outcomes.
In the multivariate analysis , sad and fear symptoms were significantly and independently associated with a higher risk of attempted suicide in the elderly.
In the multivariate analysis , TNM stage and G8 score were independent prognostic factors for OS.
In the multivariate analysis , wealth was significantly associated with depressive symptoms in men , whereas education and income was so in women.
In the multivariate meta-regression model , baseline HbA1c , fasting glucose , and type of DPP-4 inhibitor explained @number@ % of total variance.
In the multivariate models , the significant predictors among men related to physical fitness , whereas among women they pertained to social activities and morbidity.
In the near future , an aging and physically changing workforce risks reduced work ability.
In the near future , new approaches should decrease the high morbidity and mortality associated to these types of patients.
In the neck flexion position , an anterior shift of the cervical cord was evident.
In the nephrotoxic serum nephritis model , which induced immune-complex mediated injury , ARF6 PodKO mice exhibited aggravated proteinuria.
In the Netherlands , a team specialised in elderly care accomplishes home-based assessments.
In the Netherlands , rates of institutional LTC use are falling , whereas homecare use is growing.
In the Netherlands the average age in healthcare facilities is on increase.
In the neuron , Pin1 promotes cellular health by restoring phosphorylated tau and amyloid precursor protein to a functional state.
In the new approach , DNA fibers from cells carrying laser localized ICLs are spread onto microscope slides.
In the new approaches stable population size is a dynamic equilibrium between different mortality and fecundity factors instead of an arbitrary fixed carrying capacity.
In the next few years , the figure of the expert patient will undoubtedly be highly useful.
In the next section , we focus on clinical importance of orexin in human obesity , sleep , and aging.
In the next step , the effect of BMI on the incidence of hypertension stratified by sex was evaluated.
In the NHANES cohort , elevated B12 was associated with RKF after full covariate adjustment ( OR @number@ @percent@ CI @number@ @date@ ) .
In the No Dairy condition , brachial flow-mediated dilation was reduced ( @number@ ± @percent@ , P < @number@ vs. baseline ) .
In the non-institutionalized group , people aged @number@ years or more reported a significantly lower well-being ( PWI ) than younger counterparts.
In the nonsocial condition , infants view objects on computer screens.
In the normal brain , age is associated with changes in gene expression.
In the normal sample , mean estimates generally underestimated differences in brain volume at percentile ranks below the mean.
In the normal state of a cell , endogenous antioxidant enzyme systems maintain the level of reactive oxygen species generated by the mitochondrial respiratory chain.
In the Norwegian sample , the prevalence of consumption of alcohol were @percent@ and @percent@ for women and men , respectively.
In the no vision condition , visual feedback was removed for the last @number@ s of each trial.
In the nucleus accumbens and olfactory tubercle , CRF1 binding was initially the same in juveniles , but became greater in adult females.
In the @number@ months after initiating treatment , @percent@ received a serum testosterone test and @percent@ received a PSA test.
In the @number@ NHAMCS dataset , no cases of elder abuse were recorded for the @number@ older adult ED visits.
In the @number@ ( @percent@ ) persons with cognitive impairment only , apathy was correlated to a lower score on the EQ-5D thermometer.
In the @number@ studies ( @percent@ ) reporting analyses of gender differences , women were underrepresented in both intervention and control groups.
In the @number@ survey , all responded except Nicaragua , for which information was provided by national society presidents in adjacent countries.
In the @number@ survey , @percent@ of patients reported that they never felt lonely in a single room.
In the Old-Ad group , the correlation between the RE score in FL and TMT B-A / A suggests an impairment in mental flexibility.
In the older adult group alone , step width in the occlusion at T-2 steps condition increased relative to that in full visibility conditions.
In the older adult , prudent , personalized therapy , with less rigid targets for patients at higher risk of hypoglycemia , is essential.
In the older adult sample , significant positive associations were found between recollection estimates and normalized hippocampal volumes.
In the older group , men's loneliness was related to having been bullied , and conflicts between parents.
In the older group , smaller striated muscle cells dominated over the larger ones.
In the older groups , the distribution of superficial corneocytes was more regular.
In the older patient with cancer , there can be problems of dietary intake next to the effects of ageing per se.
In the oldest but not the younger age groups , abstainers reported significantly higher psychological distress relative to light / moderate drinkers.
In the oldest group , arm swing decreased during dual task and increased during the fast walking condition ( p < 0.0001 ) .
In the oldest-old ( 80-97 y , n = @number@ ) , higher LIBRA scores did not increase the risk for dementia.
In the open-label period , sustained effects on lipid parameters were observed with anacetrapib and the treatment was generally well tolerated.
In theory , RNAi responses can selectively target intersecting oncogenic pathways to induce a tumor cell specific RNAi synthetic lethal response.
In theory , such molecules could prevent dozens of diseases simultaneously , potentially extending healthy years of life.
In theory , the aforementioned age-related changes in the pulmonary circulation may conspire to make elderly individuals more susceptible to gas exchange abnormalities during exercise.
In the other cases , the surgical results were satisfactory at the 6-month follow-up.
In the other three group comparisons , the impact was minimal ( d ≤ @number@ ) .
In the other three subgroups covering @percent@ of the participants , vitamin E did not affect mortality.
In the overall and non-AF populations , aging and female gender were associated with longer BSA-indexed LAAs.
In the overall group , sex by cortical Aβ interaction was significant for delayed recall only.
In the overall population , median PFS was @number@ weeks and median OS was @number@ weeks.
In the overall population , @percent@ of subjects were still on therapy after @number@ months.
In the papillary dermis a significant reduction of the capillary area was seen in the 7th , 8th and 9th decennium.
In the paracentral zone extending to 6-mm diameter , correlation analysis suggested that CET was inversely associated with age ( P < @number@ ) .
In the parietal cortex , such a DLB-associated instability of rDNA was not accompanied by any major changes of methylation of the rDNA promoter.
In the past , antioxidants were used primarily to control oxidation and retard spoilage , but today many are used because of putative health benefits.
In the past decade , a significant improvement has been done in the management of pulmonary arterial hypertension , a devastating disease.
In the past decade most developed and several developing countries have recommended influenza vaccination for those > @number@ years of age.
In the past decade our understanding of SIRT6 significantly increased in many different aspects.
In the past decades , numerous efforts have been made to uncover the gene regulatory mechanisms of cellular senescence.
In the past decades , the idea of a bone-muscle unit has emerged.
In the past few years , iPSCs have been the subject of intensive research towards their application in disease modeling and drug screening.
In the past few years , there has been an increasing awareness of the regional vulnerability of the hippocampus to age-related processes.
In the past , however , production was higher in Okinawa.
In the past , it has been assumed that all the biological and medical changes that occur in old age are deleterious.
In the past , long-term care ( LTC ) facilities played an essential role in the livelihood of this population.
In the past , many researches pointed out that these patients can improve their balance sensation by exercise.
In the past @number@ years , five new agents have been approved for metastatic , castration-resistant prostate cancer.
In the past @number@ years , mtDNA has made significant contribution to molecular ecology and phylogeography.
In the past @number@ years , this agent has shown neuroprotective effects in animal models of traumatic brain injury ( TBI ) .
In the past , revascularization required surgical bypass or endarterectomy , accompanied by the morbidity and mortality associated with a major surgical procedure.
In the past several decades , some risk factors for cardiovascular disease have improved , while others have worsened.
In the past , the only option for treating laxity was surgery.
In the past two decades researchers have devoted their effort to study and explain the mechanisms involved in the pathology of this devastating disease.
In the past two decades , there has been an exponential increase in the use of medicinal herbal products around the world.
In the past year , type @number@ diabetes has been described in two meta-analyzes as an independent risk factor for OA.
In the patient fibroblasts , we observed higher levels of TAZ and YAP.
In the patient group , ≥ @number@ of the same risk factors as in the whole group analysis showed a statistically significant influence.
In the pediatric population the liver area and volume continuously increased with age.
In the perinatal period , fetal hemoglobin is synthesized at high levels followed by a decline to adult levels by one year of age.
In the pharmacokinetic parameters for PIPC , total clearance was slightly lower in the nephrotoxicity group than in the non-nephrotoxicity group.
In the pharmacological manipulation group , subjects demonstrated no increase in autonomic or endocrine stress response , after exposure to psychosocial stress.
In the PNF group was found significantly higher postoperative independence ( SAP ) and shorter length of stay in hospital compared to conventional physiotherapy group.
In the post menopause total testosterone levels were significantly higher in African Americans compared to Caucasians ( p = 0.012 ) .
In the postoperative period , three patients required prolonged mechanical ventilation due to airway swelling , respiratory failure , and infection.
In the practitioners ' opinion , @percent@ of these problems , particularly physiological and mental ones , could lead to immediate consequences.
In the precentral gyrus , mild loss of Betz cells and gliosis together with neurophagia were observed.
In the precision grip task , however , training effects as found for the control group seem to be blocked in the experimental group.
In the preintervention , the blood pressure ( BP ) and FVR were measured after @number@ min of rest.
In the presence of active viral replication , PGRN expression is increased functioning as an anti-viral factor as well as a neuroprotectant.
In the presence of a stimulus , the amount of saliva secreted from the parotid gland increases to @percent@.
In the presence of a stranger , pain was reported as less unpleasant and facial expressions of fear were more frequent.
In the presence of BAY , IL-1β induced IL1B mRNA levels were decreased by 6-fold.
In the presence of multiple other risk factors for disability , gait speed significantly increased the area under the receiver operator characteristic curve.
In the presence of recombinant Klotho ( rKlotho ) , we show that Wnt5A internalization and signaling is decreased in high Wnt5A-expressing cells.
In the presence of TBAD , true and total artery lumen morphology were assessed.
In the present article an overview of different experimental wear test scenarios considering clinically relevant polyethylene wear situations using severe test conditions is presented.
In the present article we examine the physiology of secretion of pineal hormone melatonin and its role in the vital processes of the body.
In the present article , we summarize the current therapeutic tools and their combination partner drugs.
In the present case-control study , PCNT gene expression was increased by @percent@ in @number@ out @number@ DS samples compared with normal subjects.
In the present chapter we review the potential benefits of EE in aged rodents and in animal models of Alzheimer Disease ( AD ) .
In the present context of migration , these resources interact at a transnational level , challenging family and State migratory regimes.
In the present context , particular attention is given to Emissions and Furnace PM.
In the present contribution , the data are quantitatively analyzed based on the theoretical model of the electrokinetics of soft particles.
In the presented model , information read from the introduced epigenome may alter gene expression that may be stopped or re-activated.
In the present longitudinal study , performance on the MMSE and the NINL tests were compared over a 4-year period.
In the present minireview the mechanisms whereby PARP activity inhibition may improve muscle mass and performance in models of cancer-induced cachexia are discussed.
In the present narrative review , we critically evaluate cross-sectional , prospective and intervention studies examining the relationship between diet and frailty development and prevention.
In the present paper , the authors sought to determine whether destination memory can be improved in older adults using emotional stimuli.
In the present paper , the genetic and clinical features of CH caused by defects in the peroxide generator system will be revised.
In the present paper we discuss the main issues that are still limiting the clinical and research implementation of the cognitive frailty construct.
In the present paper we have reviewed the available evidence and based our discussion on data derived from a specific clinical case.
In the present population-based sample , alcohol intake was low and the frequency of moderate alcohol consumption increased over the years.
In the present report , we extend previous findings in the 5XFAD mouse model with regard to a characterization of behavioral deficits and neuropathological alterations.
In the present review , I would like to narrow the discussion to the more classical roles of autophagy in supporting viability under nutrient limitation.
In the present review , we discuss several methodological problems that limit the conclusions of many studies.
In the present review , we evaluate the pharmacology of ginseng with the traditional viewpoint of Yin and Yang components.
In the present review , we highlight emerging evidence that supports the notion that extracellular DAMPs act as crucial proinflammatory danger signals.
In the present review , we overview the pathomechanism of vascular calcification and the involvement of posttranslational modification of epigenetic regulators.
In the present review , we provide a background regarding why iPSCs represent a paradigm shift for central nervous system ( CNS ) disease modeling.
In the present review we summarize the most important results of experiments about nicotinic neuroprotection and neurotoxicity in humans and animals.
In the present short communication , we would like to suggest a possible mechanism for the healing effects exerted by the Er : YAG laser.
In the present studies we assessed the impact of GSPE exposure on the ultrastructure of PHFs isolated from Alzheimer's disease brain.
In the present study , affects of meal ingestion for SDPTG in young and elderly subjects are examined.
In the present study , a group of younger and a group of older adults performed a cognitive task for 3h.
In the present study , a new C-geranylated flavone , paucatalinone C ( @number@ ) and five known C-geranylated flavanones ( 2-6 ) were isolated.
In the present study , gait kinematic properties of older fallers and non-fallers were compared under cognitive and motor dual-task conditions.
In the present study , however , @date@ is shown to interact with the -13915 G SNP region DNA sequence by EMSAs and gel supershift.
In the present study population , the magnitude of LLD ranged from @number@ to @number@ cm.
In the present study population , the power model was a superior fit to the observed data compared with the double Gaussian model.
In the present study , SH-SY5Y cells were treated with MG to induce cell death.
In the present study , SH-SY5Y cells were utilized to determine the effects of tenuigenin on 6-hydroxydopamine ( 6-OHDA ) -induced injury.
In the present study , Silybum marianum flower extract ( SMFE ) was demonstrated to possess antiglycation activity.
In the present study , single- and dual-task effects were addressed in the context of aging.
In the present study , SMAP2 is detected on the TGN in the pachytene spermatocyte to the round spermatid stages of spermatogenesis.
In the present study , TCR-Vβ repertoires of cancer patients were primarily analyzed by flow cytometry.
In the present study , the cross-species effects of Hsp22 expression were tested.
In the present study , the effects of AST against collagen reduction in UV-induced skin aging in human skin fibroblasts were investigated.
In the present study , the effects of LYC on oxidative stress-induced cognitive defects and the underlying mechanisms were determined.
In the present study , the interaction of free radicals and carotenoid antioxidants in the human skin under in vivo conditions was investigated and summarized.
In the present study , the prevalence , the potential risk , and the protective factors of depression in the Chinese older population were investigated.
In the present study , the same analysis was performed in aged skin in order to better understand the defects which occur with aging.
In the present study , the variables with significant correlations were assessed using the multivariate logistic regression model.
In the present study , this relationship is argued to be partly explained through generative goals.
In the present study , trustworthy-looking and untrustworthy-looking faces were paired with cooperation or cheating in a cooperation game.
In the present study , ursolic acid inhibited the superoxide anion generation and elastase release in human neutrophils.
In the present study , VSMC response to curcumin treatment was evaluated.
In the present study we address this in two ways.
In the present study , we aimed for a quantitative interpretation of the observed changes in wall behavior with age using a constitutive modeling approach.
In the present study , we aimed to evaluate the frequency of mtDNA @number@ bp deletion in CRC tissues and its association with clinical factors.
In the present study , we also evaluated the age-related changes of DMT1 and FPN1 by using Western blot and qPCR.
In the present study , we analysed how age affected social desirability and acquiescence , and how this effect impacted the age-aggression relationship.
In the present study , we analyzed the evolutionary implications of this STR across species.
In the present study , we analyzed the relationship between SDB severity , cerebrospinal fluid ( CSF ) Alzheimer's disease-biomarkers , and the ApoE alleles.
In the present study , we assessed the spatial distribution of cortical damage in amyotrophic lateral sclerosis by using a cortical thickness measurement approach.
In the present study , we assessed whether changes in CRRT vary with age , body sites and gender in a normal Chinese population.
In the present study , we assess the skin friction coefficient in a larger Chinese population.
In the present study , we assess the stratum corneum ( SC ) hydration in sun-exposed males and females.
In the present study , we characterized the behavioral phenotype of male UBB ( @number@ ) transgenic mice at different ages.
In the present study , we compared the transcriptional levels of various miRNAs in TECs from young and aged mice using microarray analysis.
In the present study , we created an RM display depicting a pattern of implied ( clockwise ) rotation of a rectangle.
In the present study , we demonstrated that continuous irradiation with a 633±3-nm LED exerted anti-aging effects in both in vitro and ex vivo experiments.
In the present study , we demonstrated that MafB protein stability is regulated by JNK and identified a phosphorylation site , Thr62.
In the present study , we evaluated changes in the strength of associations between T2DM and birth size and maternal weight with age.
In the present study , we evaluated relationships between cognitive performance deficits and resting cerebral metabolism in euthymic older adults with bipolar disorder.
In the present study , we evaluated the progression of comorbidity in our COPD model.
In the present study , we examined immunoexpression of proteins participating in the above-mentioned mechanisms , in the brain of patients with viral meningoencephalitis.
In the present study , we examined memory for events and memory for locations in the context of elicited imitation.
In the present study , we examined the association between salivary cortisol in older age and cognitive ability across the life course.
In the present study , we examined the contribution of ARFGAP3 to prostate cancer cell biology.
In the present study , we examined the effect of interpersonal sensitivity on telomere length in healthy subjects.
In the present study , we examined the expression and roles of phosphorylated nestin in pancreatic cancer cells.
In the present study , we examined the hypothesis that cognitive map formation is supported by rest-related integration of new spatial memories.
In the present study , we examined whether EGCG may inhibit expression of MMP-1 in heat-stimulated human dermal fibroblasts.
In the present study , we examined whether perceptual learning methods can be used to improve performance of older individuals.
In the present study , we examined whether the capacity to learn deteriorates with aging.
In the present study , we examined whether this SNP is associated with cognitive function in a non-clinical population.
In the present study , we explored miRNAs associated with endocrine therapy resistance in breast cancer.
In the present study , we filled this gap in two ways.
In the present study , we focused on the relationship between Alzheimer's disease ( AD ) and O-glycan , another type of glycan.
In the present study , we for the first time demonstrated that IGF-1 protects against Aβ-induced neurotoxicity via inhibition of PUMA expression and Bax activation.
In the present study , we found longitudinal observational evidence that suggested that increases in systemic inflammation are associated with declines in lung function.
In the present study , we generated BRINP1-deficient ( KO ) mice to clarify the physiological functions of BRINP1 in the nervous system.
In the present study we have addressed the potential impact of oxidatively modified proteins on the altered metabolism of senescent human satellite cells.
In the present study we have reviewed these mechanisms and some new mechanisms are also proposed.
In the present study , we investigated age-related changes in palatine tonsillar B cell subsets and immunoglobulin ( Ig ) isotypes.
In the present study , we investigated cognitive dysfunction , locomotor activity , and mitochondrial dysfunction involved in D-gal exposure in mice.
In the present study , we investigated life span development of item-specific PI.
In the present study , we investigated the cerebrovascular protective effects of Polygonum multiflorum against ischemic brain injury using an in vivo photothrombotic mouse model.
In the present study , we investigated the effect of habitual exercise on Klotho , with a particular focus on arterial stiffness.
In the present study , we investigated the effect of testing for these two recall types , using verbally encoded action phrases as learning materials.
In the present study , we investigated the impact of common FOXP2 polymorphisms with regard to frontotemporal lobar degeneration ( FTLD ) .
In the present study , we investigated the localization of D-β-Asp-containing proteins in cases of pterygium , one of the most prominent age-related ocular conditions.
In the present study , we investigated the significance of these mutations in survival , proliferation , and oxidative stress tolerance in human cells.
In the present study , we investigated the usage of DNA vaccines as an alternative to MK2-23 mAb immunization.
In the present study , we investigated whether this socially relevant form of orienting is reflexive and whether it is influenced by age.
In the present study , we isolated a novel hemagglutinin from an edible legume and explored its growth-inhibitory effect on osteocarcinoma and liver cancer cells.
In the present study we isolated ASC from the heterogeneous stromal vascular fraction of subcutaneous abdominal fat pats of adult women.
In the present study , we isolated tissue-specific stem cells from the human submandibular salivary gland ( hSGSCs ) .
In the present study we measured the levels of the HNE-modified lipoic acid in brain of subjects with AD and age-matched controls.
In the present study , we propose that mindfulness may be an important mediator of this association.
In the present study , we recorded the event-related potentials ( ERPs ) of younger and older adults during VWM maintenance and retrieval.
In the present study , we show that cognitive function in later life does seem affected by prenatal undernutrition.
In the present study , we synthesized a series of organoselenium compounds and evaluated their possible chemopreventive properties in human prostate cancer LNCaP cells.
In the present study , we tested this hypothesis in young and older participants using a perceptual landmark task.
In the present study we used gas chromatography-mass spectrometry ( GC-MS ) technology coupled with multivariate statistical analysis to study profiles of FFA in AD.
In the present study , we used mouse splenocytes and found that estradiol inhibited Th17 differentiation through downregulation of Rorγt mRNA and protein expression.
In the present study , we used the ReHo index to explore whole brain spontaneous activity pattern in MCI.
In the present study , we utilized a well-characterized AD-relevant transgenic mouse strain to assess mitochondrial respiratory deficits in both brain and muscle.
In the present work , 3xTgAD and wild type 129 / C57BL6 male and female non- and environmentally enriched mice were used.
In the present work , we employ reverse-engineering approach to construct the most detailed computational model of p16-mediated pathway in higher eukaryotes.
In the present work we investigated the effects of c-Myc knockdown in endothelial cell functions essential for angiogenesis to define its role in the vasculature.
In the previous @number@ years , a variety of experimental paradigms and methods have been employed to study inhibition.
In the previous study , we designed a minimally invasive cholecystolithotomy based on percutaneous cholecystostomy combined with a choledochoscope ( PCCLC ) under local anesthesia.
In the principal components analysis does not saturate all dimensions in its theoretical factor.
In the problem total scale , boys were scored higher than girls by mothers , but not by fathers , in both age groups.
In the process , entrepreneurship is being stimulated , yet little is known about intra-hospital dynamics leading to entrepreneurial behavior.
In the process of atherosclerosis , vascular effects of androgen remain poorly understood and have been controversial for a long time.
In the process of development of gastritis , ulceration and cancer , several cellular and molecular steps follow each other.
In the process , we also show how involvement in religion may help promote interests.
In the progression group , baseline serum TSH levels were lower than those in nonprogression group.
In the prospective analysis we calculated different levels of physical activity and the prevalence of positive changes in WAI-category from baseline to follow-up.
In the prospective and validation studies , stroke incidence was affected by neither executive nor memory scores.
In the prostate , AIM : Pancreaticoduodenectomy ( PD ) is still the only curative treatment for periampullary cancer.
In the protamine sulfate perfusion model , which induced acute podocyte effacement , ARF6 PodKO mice were protected from podocyte effacement.
In the proximal tubule , increased CMA results from protein or calorie starvation and from oxidative stress.
In the rat model , we have shown that the sympathetic nervous system participates in regulating the follicular development during ovarian ageing.
In the realm of aesthetic cutaneous medicine , the evolution and creativity in the use of botulinum toxins has been swift and ever changing.
In the recipient sites , the contours of the articular surface of the medial and lateral femoral condyles were assessed.
In the recovery group , the values of this panel significantly improved at @number@ and @number@ months.
In the redundant target effect , participants respond faster with two ( redundant ) targets.
In the regression model analysis , aging and ADL impairment were the principal clinical predictors that differentiated drivers from ex-drivers.
In the remaining documents , the right to leisure is mostly referred to indirectly or in a narrow legal construction.
In the remaining eight ulcers , the median healing time was @number@ weeks ( interquartile range , 4-29 weeks ) .
In the remaining @number@ patients , the prevalence and clinical features of de novo NAFLD after PD were examined.
In the remaining @number@ ( @percent@ ) patients , non-AR was diagnosed.
In the replication stage , we performed genotyping of significant and suggestive results from the discovery stage.
In the restraint trials , the flanker cues ( XXXX ) prompted the participants to withhold responses occasionally.
In the reticular dermis the capillary bed remained unchanged.
In the retina , messenger ribonucleic acid ( mRNA ) coding for trypsin-2 , @number@ and @number@ was present.
In the retina , these pathways can result in an irreversible tissue scar , which is related to malfunction and loss of function.
In the reversal cohort , @number@ ( @percent@ ) had eGFRs < @number@ mL / min / 1.73 m ( @number@ ) .
In the review , delirium etiologies , prediction , diagnosis , prevention , and treatment are outlined.
In the revised version of the FD2 test , a white background is used instead of a backlit background.
In the RJ group , tear volume significantly increased after intervention ( p = @number@ ) .
In the ROC curve analysis , the areas under the curve for REMS , RAPS , and MEWS were @number@ @number@ and @number@ respectively.
In the ROVIGO cohort , diabetes , left ventricular hypertrophy , coronary and cerebrovascular diseases were more represented in men.
In the RTOG evaluation , we analyzed all eligible GBM cases from @number@ RTOG studies from @number@ to @number@
In the RTS model , C statistics were @number@ and @number@
In the Russian sample , past drinking was also assessed.
In the sALS cohort , there were no significant differences in these disease characteristics between the C9orf72 repeat expansion carriers and the noncarriers.
In the same cohort , we investigated whether impairment in specific cognitive domains was associated with CC tissue loss.
In the same patients , shopping and transportation were reported as the most frequent IADL functions lost.
In the same period , most adults continued to report good general health ( 93%-86% ; P = .148 ) .
In the same way , @number@ patients had PSA > @number@ ng / mL.
In the SAP-abnormal hemifield , the rate of change was significantly negative for both tests ( P < 0.001 ) .
In the school-age children , self- and proxy-reported HRQoL was well within or even above the norms , while increased total behavioural problems were found.
In the SD versus control classification task , both algorithms achieved accuracies of greater than @percent@.
In these cases , a direct surgical cut down on to the superior ophthalmic vein ( SOV ) is necessary.
In these cases , age assessment must be performed without the corrections suggested by the literature for different ethnic groups.
In these cases heteroplasmy was correlated within sibpairs in Finnish and northern Italian samples , but not in southern Italians.
In these cases , if mild nuclear atypia is present , they are best addressed as cellular fibroma.
In these cases , it is classified as combined HS.
In these circumstances , countries in transition , like Serbia , face difficult challenges in financing their health systems.
In these clinical trials , calcitriol was used as a monotherapy and in combination with other therapeutic bone agents.
In these cohorts , individual differences in personality traits continued to be stable even in very old age , mean-level changes accelerated.
In the second and third weeks , they were asked to increase their steps by @percent@ from the previous week.
In the second experiment older adults , as well as young adults , showed an early isolation effect.
In the second family , a splice mutation , IVS 9 + 2T > G , was found.
In the second half of this review article , we introduce the foodborne outbreak cases caused by E. coli in natural foods and food products.
In these conditions , inflammation coordinates energy distribution and energy demand between tissues.
In the second part , a number of prospective aging indicators that take account of remaining life expectancy , will be studied.
In the second part of the paper we describe neuroprotective and neurotoxic effects of nicotine also mentioning the underlying molecular mechanisms.
In the second part of the study , groups A and C were treated for @number@ months with L-thyroxine.
In the second part of this study these regression formulae were applied blind to teeth from two individuals with known medical histories.
In the second part , treatment of focal hyperhidrosis with emphasis on axillary hyperhidrosis is addressed.
In the second phase , four testing conditions were defined , corresponding to a baseline and the three equally difficult cognitive tasks.
In the second phase , survivors ( aged > or = 80 years , n = 339 ) were followed from @number@ to @number@
In the second phase , the association between excessive polypharmacy and mortality ( HR @number@ @percent@ CI @number@ @number@ ) remained significant after adjustments.
In the second round , consumers were informed of the brand or quality grade prior to sampling.
In the second session , all student and older adult participants created a painting to represent their partner.
In the second stage , a Bayesian inference method is used to select attributes from which a predictive model is built.
In the second stage of the protocol , @number@ consecutive unselected CWC patients with lower extremity wounds underwent home sleep studies.
In the second stage these problems were classified by the health team members by epidemiological criteria ( size , vulnerability , and transcendence ) .
In the second study , more than @number@ men aged @number@ to @number@ years responded to a postal survey on health behaviors and masculinity.
In the second study @number@ undergraduate students produced life scripts for the same @number@ events.
In the second study , we explored the experiences of staff who provided services to elderly housing residents.
In the second substudy , the OR was @number@ ( @percent@ CI , @number@ @number@ P = 0.053 ) for this group.
In the second task ( time-varying F0 ) , listeners relied on variations in F0 to judge intonation of synthetic diphthongs.
In the second wave , @number@ participants were interviewed ( response rate of @percent@ ) .
In these elderly subjects , HPSV was exceeded and laryngeal penetration of the water was seen.
In these focus group sessions , problematic activities threatening the independence of elderly people were discussed.
In the segmented regression , there was no significant guideline effect on overall ICS prescription rate.
In these homogeneous groups , tonometry methods were independent of CCT and CC.
In these last years , growing attention ( even beyond the traditional boundaries of geriatric medicine ) has been given to physical performance measures.
In these latter countries age-related increases of disability , though , were steeper than in the US , especially in Eastern and Southern Europe.
In the self-selected speed condition @percent@ of participants had a positive linear or quadratic relationship of R ( @number@ ) ≥0.90.
In these mice , the tumor suppressor isoform of CUGBP1 is protected from Gank-mediated degradation.
In these new criteria , progress in biomarker identification and amyloid imaging studies in the past @number@ years have added critical information.
In the senile lung , both Wnt4 and Wnt5a levels increase and both Wnt-s increase myofibroblast-like differentiation.
In the sensitivity analysis of @number@ hip fracture patients ( mean age @number@ years , @percent@ women ) , this pattern remained largely unchanged.
In the sensitivity analysis , the associations were similar but attenuated when physical activity was measured using the subjective physical activity questionnaire.
In these papers we looked up the words : geriatrics , asthma , aging , immunosenescence , and we chose those papers with clinical relevance.
In these patients , a program of lung function monitoring and pulmonary prophylaxis by means of elimination of specific risk factors in adulthood is advisable.
In these patients , osteoclasts play leading roles in bone loss and fracture.
In these patients PASP decreased < @number@ mmHg after @number@ and @number@ year in seven , nine and in all but one patient , respectively.
In these patients , repeatability of serial readings was good with CVs < 5% and precision of less than ±10%.
In these patients , the CV was > 5-10%.
In these plaques there is a progressive accumulation of both lipids and collagen and a decrease of inflammation.
In these regions , healthy controls showed decreases and patients showed increases in activity with practice.
In the series of experiments reported here , I describe an unintuitive and robust effect in the opposite direction.
In the seropositive-only sample , there was an inverse relationship between anti-T. gondii titer and performance on the selective reminding test.
In these slices , kynurenine-derived KYNA also failed to inhibit extrasynaptic NMDARs , which could , however , be inhibited by exogenously applied KYNA.
In these studies , females were underrepresented in the control groups.
In these studies , @percent@ to @percent@ of exercises were assessed as providing a moderate or high challenge to balance.
In these subjects , p53 protein was detected in the cytoplasm or in the nucleus of the cerebellar nerve cells.
In these , the growth-rate constant represents the relative growth rate instead of merely an unspecified growth coefficient.
In these trials , patients were treated with @number@ mg or @number@ mg per day of the defined extract EGb @number@ or placebo.
In the setting of cardiovascular disease , a number of biomarkers have become an integral part of diagnostic and risk stratification strategies.
In the short-form @number@ questionnaire analyses , rhinitis was independently related to a decrease in the physical aspects of quality of life.
In the Short Form @number@ scores , chronic persistent cough was independently related to impairment of quality of life , predominantly in the mental component.
In the short-term , there was a small , but statistically significant @number@ beats per minute decrease in heart rate with escitalopram compared with placebo.
In the simulated data approach , we determined a false positive rate < 1%.
In the skeletal muscle , we found two populations of cells with either low or high mH2A levels.
In the skin , activation of LXR induces keratinocyte differentiation and improves epidermal permeability barrier homeostasis.
In the skin , RIPK1 functions via its RHIM to counteract ZBP1 / DAI-dependent activation of RIPK3-MLKL-dependent necroptosis and inflammation.
In the skin this is associated with an increased incidence of epidermal malignancies and infections.
In the socio-medical assessment age-related normative values should be used to determine residual capacity.
In the spinal cord , marked atrophy of anterior and posterior roots was found.
In the sporadic form of CJD the only known risk factor is the codon @number@ polymorphism.
In the steady-state heart , resident cardiac macrophages remove senescent and dying cells and facilitate electrical conduction.
In the studied groups also body mass index ( BMI ) and body fat content were analyzed.
In the studies that were included in our analysis , changes of adiponectin levels ( when present ) were also evaluated.
In the study group , @number@ subjects were normotensive , @number@ had untreated hypertension , and @number@ had treated hypertension.
In the study presented here , we hypothesize that DNAmAge in blood is associated with cross-sectional and longitudinal cognitive abilities in middle-aged individuals.
In the study reported in this article , we tested whether Notch activation could be used to prevent or delay sheet culture-induced cell aging.
In the study we report here that we used a multistage genome-wide association study to identify genetic determinants of telomere length.
In the subacute to chronic form , a painless indurated mass can spread to the skin , leading to draining sinus tracts.
In the subgroup analyses , we found the age limit and traditional risk factors of IgAN may be the sources of heterogeneity between studies.
In the subgroup analysis , only the problem-solving approach showed a positive effect on emotional status.
In the subgroup analysis , these higher depression score effects were largely limited to parents with high school graduate offspring.
In the subgroup with a fall history , fall rates were @percent@ on low dose , @percent@ on medium doses and @percent@ on higher doses.
In the subgroup with intermediate BMI and stable weight , there was no association between protein intake ( E% ) and percent body fat.
In the subjects with MCI but not in NE , cortical thickness in frontoparietal AD signature regions correlated with AS performance.
In the sub-population with no visual problems , median Frisby stereoacuity was similar at @number@ @number@ and @number@ arcsec respectively.
In the sub-sample including age and BMI matched women the difference of regional fat parameters among menopausal status was no more statistically significant.
In the sub-scale analysis , higher scores of timidity were significantly ( β = @number@ p = @number@ ) associated with shorter telomere length.
In the supernatant collected from @number@ healthy subjects , no correlation was seen between salivary DJ-1 or α-syn with age.
In the Swedish samples , @number@ controls were heterozygous for A673T and all AD cases were homozygous for the A673 allele.
In the target-locked ERPs , there was an increased frontal focus of the P3b in older adults.
In the TBI group , choline ( membrane degeneration / inflammation ) was elevated for both ROIs at the post-acute but not chronic period.
In the temporal analysis , participants with low education had longer execution time for commands on the first four blocks related to working memory.
In the testes , cyclin E-Cdk2 phosphorylates Mybl1 and Dmrtc2 , two meiotic transcription factors that represent key regulators of spermatogenesis.
In the test group , the accuracy was @percent@ and the AUC was @number@
In the test-retest reliability assessment , the intraclass correlation coefficient ( ICC ) was @number@ ( P < @number@ ) .
In the test without the visual control both groups showed statistically significant deterioration in most indicators of stability.
In the third experiment , the just-noticeable differences of pitch contour discrimination were measured for both groups.
In the third phase , attributes of empowerment were extracted from the first and second phases.
In the third study , we examined barriers and facilitators to substance abuse treatment among Asian Americans and Pacific Islanders in Hawaii.
In the third version , visually distinct trials were presented in a reverse order of presentation ( longest set size first ) .
In the three groups , the calcified arteries showed no significant differences between T0 and T12 while significant differences were observed for the non-calcified arteries.
In the three Italian \ "pilot \ " regions , a greater decrease of HZ-related hospitalization rates occurred in comparison to other regions.
In the tinted IOL group , the green : blue ratio was linearly related to IOL dioptric power.
In the total sample , none of the EEG spectral measures were significant predictors.
In the training groups , the subjects engaged in @number@ min of training twice a week for @number@ weeks.
In the treated PD cohort , motor performance measures changed gradually in contrast to a steady decline in striatal FDOPA uptake.
In the treatment of depression in AD , non-pharmacological and pharmacological therapies are applied.
In the treatment of old people polypharmacy is widely used.
In the two groups , the absence of vision implies an increase of AP , ML and V impulsions and GRF variability.
In the UK , and abroad there has been a recent rise in platelet component demand.
In the UK , these strains are considered to be rare and mainly severe.
In the unadjusted model , five-year weight loss was not associated with dietary pattern.
In the unique microenvironment of the dental pulp , the triad of tissue engineering would require infection control , biomaterials , and stem cells.
In the United States alone , chronic wounds affect @number@ million patients.
In the United States , these care needs are often not met , and addressing them is an urgent priority.
In the United States ( US ) , cardiovascular ( CV ) disease accounts for nearly @percent@ of national health care expenses.
In the United States , West Nile virus ( WNV ) causes annual seasonal outbreaks that fluctuate in size and scope.
In the univariate and probabilistic sensitivity analyses ( PSAs ) the robustness of the results was tested , and various additional scenario analyses were conducted.
In the univariate sensitivity analysis the model appeared to be robust.
In the untrained limb , VT improved in young for both sham and anodal-tDCS conditions , but only following anodal-tDCS for the older adults.
In the US alone , the estimated annual cost of HZ-related cases in the ≥65 age cohort is approximately @number@ Billion US $ in @number@
In the U.S. , aminolevulinic acid ( ALA ) has been used in an off-label manner with photodynamic therapy for the treatment of chronic photodamage.
In the U.S. , Asian populations are of particular concern because of their seafood consumption behaviors.
In the U.S. , cancer is a disease of aging.
In the U.S. , cancer is a disease of aging.
In the US cohort , age > @number@ male sex , and cirrhosis were associated with HCC on multivariable analysis.
In the US , diet represents amount 30-35% of death causes related to cancer.
In the U.S. , they represent the 4th-6th leading cause of death and have an estimated cost of @number@ billion dollars.
In the U.S. where filial norms are relatively weak , anticipated support from others is no less important for health than anticipated support from children.
In the UV-irradiated animal model , PLE significantly reduced epidermal skin thickness and MMP-13 expression induced by UV.
In the validation sample , the accuracy of the new and the published BIA equations was tested by pure error.
In the Variolink II group , zirconia surfaces were silanized ( Monobond-S ) , and adhesive resin ( Heliobond ) was applied and photopolymerized.
In the vascular system , ageing is accompanied by the accrual of senescent cells and is associated with an increased risk of vascular disease.
In the vast majority of cases , codeine was used in combination with other drugs by drug-dependent individuals or with a suicidal intent.
In the ventral striatum , decreased NMDAR-mediated transmission reduced striatal neuron firing.
In the very elderly , the decline in such functions appears to relate to a reduced expression of certain co-stimulatory molecules expressed by T lymphocytes.
In the VInt the ( post-occlusive hyperemia ) post-exercise peaks in MBV and MBF were significantly lower in MA vs. YG.
In the W0-form a starting-point parameter , meaning birth or hatching value ( W0 ) , replaces the inflection-time parameter ( Ti ) .
In the WHO , active ageing configures individual lifestyle in order to expand the plasticity of ageing , based on epidemiological and public health conventions.
In the whole cohorts , @percent@ of participants were edentate and @percent@ had retained @number@ or more teeth.
In the whole population , the main mineral constituent was whewellite ( @percent@ ) , mainly organized as type Ia ( @percent@ ) .
In the whole population , the median stereoacuity on the Frisby test was @number@ @number@ and @number@ arcsec in the three age-groups.
In the whole study population , DVT was strongly associated with FMD ( risk factors adjusted β = @number@ p < @number@ ) .
In the women , the amplitude significantly increased at Fz , Fcz , Cz , Cpz , and Pz.
In the women , there was no significant group difference in change in serum sclerostin levels either before or after the above-mentioned adjustments.
In the young , activity within the medial prefrontal cortex supports this source memory benefit at study.
In the young adult population , both methods balanced covariates effectively , but only optimal full matching created representative populations.
In the young and elderly groups , @number@ ( @percent@ ) and @number@ ( @percent@ ) patients were treated with triple antiplatelet therapy.
In the younger and older men , LUTS was observed equally in those with and without the metabolic syndrome.
In the younger comparison group , no decreases in prescription rates for those drugs were observed.
In the younger group , filtering involved the bilateral insulae , the right occipital cortex , the right brainstem , and the right cerebellum.
In the younger group , majority of the striated muscle cells were mid-sized.
In the younger group , the lateral brow position was significantly higher than the midbrow ( p < @number@ ) .
In the younger group , women had higher coherence thresholds than men with presentation of @number@ but not @number@ dots.
In the young men , resting FBF was not significantly altered by BQ-123 , whereas , in the older men , FBF increased approx.
In thirty-nine ( @percent@ ) of the @number@ prescriptions studied all tablets were safe to crush and all capsules were safe to open.
In this area , Information and Communication Technologies ( ICT ) are of particular interest.
In this article , an age-dependent formula to predict the dielectric properties of biological tissues was derived.
In this article , animal and human cerebral ischemic preconditioning , its age-related difference , and its potential therapeutical applications are discussed.
In this article , dietary modifications that could play an important role in ischemic stroke prevention for the Chinese population are reviewed.
In this article , I argue that deceleration patterns may reveal surprisingly little about the heterogeneity that putatively produces them.
In this article I revisit the results of research completed in the mid-1990s and recently reviewed with women's updated input.
In this article , I summarize some examples illustrating the importance of such work and propose additional theoretical possibilities.
In this article , mechanisms through which melatonin exerts its protective role in mitochondrial dysfunction and related disorders are reviewed.
In this article , monthly stratified analysis modeling for mortality is conducted for the total population as well as the stratified elderly and younger subgroups.
In this article , multiple facets of late-life depression are reviewed , including its clinical presentation , epidemiology , and biopsychosocial causes.
In this article , @number@ more questions are presented as follows.
In this article , several approaches to ascertainment are evaluated for validity , reliability , and cost.
In this article , several policy initiatives are discussed that address the shortage of health professionals prepared to care for older adults.
In this article , the authors discuss the clinical presentation , diagnostic criteria , neuropathology , genetics , and treatments of these disorders.
In this article , the authors explored Cantonese-speaking older Chinese migrants knowledge , attitudes and expectations regarding mental illness.
In this article , the authors explore this phenomenon while reviewing some notable people and AD.
In this article , the authors focus on bipolar and multipolar RF modalities.
In this article , the authors present personal perspectives on how they became involved in the discovery and / or advancement of GPER research.
In this article , the authors present the views of Jewish law and thought regarding sexuality among older couples.
In this article , the dental and craniofacial characteristics of a 9-year-old girl with HGPS are presented.
In this article , the evidence behind these associations is described.
In this article the function of the immune system during aging is explored.
In this article , the main findings of this research are summarized , with a focus on attachment and dementia.
In this article , the potential problems associated with the manipulation of authorized solid oral dosage forms are discussed.
In this article , the role of mitochondrial homeostasis in ageing and age-dependent fat accumulation is revised.
In this article various compounds that can modify the course of the disease are discussed.
In this article , we argue for a reorientation of palliative care to explicitly integrate the premises of health equity.
In this article , we argue that in several model systems , hydrogen peroxide plays a crucial role in the induction of hormesis.
In this article , we characterize survivorship after medical treatment completion during the periods of reentry , early survivorship , and long-term survivorship.
In this article , we compare and contrast the attitudes and opinions of these populations in an attempt to define specific themes.
In this article , we consider variable selection for correlated high dimensional DNA methylation markers as multivariate outcomes.
In this article , we critically review the literature available on the relationship between TL , age and fitness.
In this article , we describe a detailed method for automatically generating tetrahedral meshes from 3D images having multiple region labels.
In this article , we describe our approach to the patient with aging of the periorbita.
In this article we describe the new technique in detail , together with practical recommendations and precautions.
In this article , we describe the recent research trends on the field of humanoid robotics.
In this article , we discuss our forthcoming plans to spread these ideas of empowerment among pharmacists.
In this article we discuss technique , indications , and benefits of performing alloplastic augmentation as an adjunct to rhytidectomy.
In this article , we examine relationships between prior military service , identity stigma , and mental health among transgender older adults.
In this article we examine the key factors that facilitate physical activity in highly active community-dwelling older adults.
In this article , we examine the particular processes and relationships involved in doing qualitative research about care with older people in rural places.
In this article , we examine to what extent the family situation of older people creates vulnerability with respect to their quality of life.
In this article , we examine varied attitudes and practices toward volunteering in later life , as shared by a group of @number@ retired women.
In this article , we introduce a quantile regression with a change-point model for longitudinal data of cognitive function in persons bound to develop AD.
In this article , we introduce the concept of cognitive reserve and explicate its potential cognitive and neural implementation.
In this article , we outline several issues related to cognitive performance and potential implications associated with aging.
In this article , we outline the different technologies and highlight the differences to help guide us in selecting the right treatment.
In this article , we outline the mechanisms governing vascular calcification and highlight its association with cellular senescence.
In this article , we outline why now is the time for social scientists to bring genetics into their research programs.
In this article we present findings from @number@ qualitative interviews with Australian women aged 55-81 who were single at the time of interview.
In this article we present our views regarding cell signaling via miRNAs.
In this article , we present research design , study findings , and important implications for researchers , community gatekeepers , and health care professionals.
In this article , we propose a method of combining multiple diagnostic tests in the absence of a GS.
In this article , we propose several multiple imputation methods for multivariate one-sided testing problem with missing data.
In this article , we provide an overview of the clinical and genetic features of AD.
In this article , we reflect on the serendipitous development of this program of research methodologically and conceptually.
In this article , we review and apply ethnobiological knowledge to biodiversity conservation in the Eastern Himalayas.
In this article , we review a set of cutting-edge statistical methods that life-course researchers can use to rigorously address their research questions.
In this article , we review both theoretical and empirical advancements in retirement adjustment research.
In this article , we review changes of psychological function in aging.
In this article , we review current understanding of the characteristics , origins , and functions of these cells.
In this article , we review different aspects of mitochondrial dysfunction and discuss potential therapeutic strategies to improve mitochondrial function.
In this article , we reviewed and updated the classification and diagnostic algorithms for identifications of autoantibodies against the coagulation factors in clotting cascade.
In this article , we review most of the efficacy and safety data on non-hormonal treatments for VMS published over the past @number@ years.
In this article , we review recent advances in understanding the mechanisms of SIRT6 action and their implications for human biology and disease.
In this article we review the age-related genetic and genomic changes that occur in the male germ line.
In this article , we review the anomalies of the amyloid model and the theoretical and empirical support for the entropic selection theory.
In this article , we review the barriers to critical care training opportunities and expanding the intensivist workforce and propose reasonable and practical solutions.
In this article we review the diverse epidemiologic evidence for the link between fertility potential , age of menopause , and women's lifespan.
In this article , we review the epidemiology , detection , risk factors , clinical significance , and pathogenesis of CMHs.
In this article we review the evidence linking deficiencies in the DNA repair pathways with neurodegeneration.
In this article , we review the evidence on inflammatory biomarkers and their potential role in prognosis and therapeutic decisions for patients with HF.
In this article , we review the history of tissue engineering as it pertains to bioengineered grafts and vessels for hemodialysis access.
In this article we review the role of AGEs in type @number@ diabetes , beyond their involvement in vascular complications.
In this article , we review the surgical anatomy , imaging modalities , and molecular biology of the lumbar IVD.
In this article , we summarize the basic knowledge involving skin aging and its biomarkers.
In this article , we summarize the current evidence base regarding the use of device therapy in elderly heart failure patients.
In this article , we summarize the various types of stem cells and their differentiation potential in vivo and in vitro.
In this article , we systematically examine the mechanisms of endothelium protection of hydroxycinnamic acids.
In this article , we systematically introduce the concepts and amelioration mechanisms of the nanomedical techniques for drug- and natural compound-loaded SLNs.
In this article , we undertake a comprehensive critical analysis of the Active Ageing Index.
In this article we use multiple imputation to fit multi-state models for survival data with interval censoring and left truncation.
In this article we will provide an overview of the epidemiology of the cardiovascular risk factors in CKD.
In this article , we will review the current models of hemostasis and the maturation of the hemostatic system.
In this aspect , GI appears to be useful as a practical guideline to help diabetic people choose foods.
In this baseline cross-sectional population-based sample , high levels of sUA were associated with a decreased risk of cognitive impairment.
In this capacity , the retrograde response may cooperate with other , related mitochondria to nucleus signaling pathways.
In this case , age equivalence arose in FOK resolution except at the lowest levels of recognition in the single-presentation condition.
In this case , multi-detector computed tomography was useful for clarifying the etiology and the abnormal anastomosis and facilitated effective angiographic embolization.
In this case , not only was there superior-to-chance performance after @number@ years but memory was also configural at both ages.
In this case , service-enriched housing for elders in high-rise buildings would appear to be beneficial.
In this case , standard testing procedures based on complete data may not be applicable or may perform poorly if the missing data are discarded.
In this case , there are several options available today in the therapeutic armamentarium.
In this case , therefore , they can be employed interchangeably , with SDMS being simpler to implement and taking less computational resources.
In this case , we assume that SMS factors , containing in CM-old are capable to trigger senescence mechanism in a paracrine manner.
In this case , we cannot know if any item is labeled fully and correctly.
In this chapter , basic diagnosis , different treatment modalities in patients with PAD are described.
In this chapter , bone quality evaluation using quantitative computed tomography is discussed among evaluation methods of various fracture risk.
In this chapter , development of HEL ELISA and its applications are reported.
In this chapter , the molecular mechanisms by which protein synthesis-promoting longevity pathways and protein degradation pathways interact with each other are discussed.
In this chapter , we describe a semiautomated method of quantitatively analyzing the histomorphometry of WAT using common laboratory equipment.
In this chapter we describe the generation and characterization of iPSC from blood or fibroblast on a routine base and focus on the integration-free methodologies.
In this chapter , we discuss the current understanding of the possible epigenetics changes that occur in rheumatoid arthritis.
In this chapter , we examine how age-related changes to cells within the central nervous system interact with comorbidities.
In this chapter we present Excess Entropy Production for human aging system as the sum of their respective subsystems and electrophysiological status.
In this chapter , we review recent development on the effects and mechanisms of acupuncture on Alzheimer's disease.
In this chapter , we review recent progress on understanding the role of noncoding RNA in Alzheimer's disease ( AD ) .
In this chapter we review the different technologies that can be applied in the analysis of protein homeostasis and metabolism in aging research.
In this chapter , we review the identification of sirtuins and their biological targets.
In this chapter , we review the structure , functions , and regulation of BubR1 in these \ "classical roles \ " at the kinetochore.
In this chapter we summarize knowledge on the role of drebrin in cell-cell communications.
In this chapter , we will discuss some of the basic laboratory procedures for cell senescence culturing methods.
In this chapter , we will review the challenge of polypharmacy and suggest ways of minimizing drug-drug interactions.
In this cohort , about half the findings above the 99th percentile were false positives.
In this cohort of Caucasian American adults , associations between carbohydrate nutrition and cancer varied by cancer site.
In this cohort study , we investigated whether these changes emerge during delirium or whether they are present before its onset.
In this commentary I provide a further opinion that we could do better within the current system using the current resources.
In this commentary , we discuss radiobiological issues arising from low-dose radiation exposure , from the cell-based to the population level.
In this commentary we discuss the goals for this protocol and the associated key challenges involved in its development.
In this Commentary , we focus on miRNAs and their roles in mammalian stem cells.
In this comparative cohort study , ABM and DTM showed equal outcome for depression and cognition.
In this context , a constant negotiation takes place between the actors.
In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence.
In this context , cardiovascular and respiratory conditions have been indicated as playing prominent roles in the determination of frailty.
In this context , computer simulations are important tools for gaining insights into the self-assembly of amyloid peptides and the molecular mechanism of inhibitors.
In this context , education modules should be developed to help couples perceive menopause in a more positive way.
In this context , epigenetic changes , both global and gene specific , are now an emerging alternate mechanism in disease initiation and progression.
In this context , evaluating the specific physiological impact of mutations that compromise genome integrity has become crucial for a better dimensioning of our knowledge.
In this context , further investigations need to be carried out.
In this context , health care policies aim to increase life span cost-effectively while maintaining quality of life and functional ability.
In this context , it is crucial to obtain ratings of modern day older adults ' everyday competence by means of appropriate assessments.
In this context , lowered expression of Atg6 or Pi3K59F in Ddc-Gal4-expressing neurons results in decreased longevity and associated age-dependent loss of locomotor ability.
In this context , neurodegenerative pathologies such as Alzheimer's disease ( AD ) account for a major part of these protein misfolding diseases.
In this context , neurotrophic factors that can prevent or delay the decline in cognitive function and central DA activity are of clinical interest.
In this context , new antioxidants preventing such effects may have a relevant role as modulators of cell homeostasis and as therapeutic agents.
In this context , new research from our lab has established SIRT6 as a key regulator of glucose homeostasis.
In this context , notably the classifier includes a sub-population of patients with minimal cognitive impairment into the pathological domain.
In this context , numerous studies have documented reduction in the functionality of synapses in various models.
In this context , nutrition is one factor that is believed to be influential.
In this context of uncertainty , the apparent clarity and certainty of a \ "dementia care pathway \ " may be attractive.
In this context , p53 reduces tissue regeneration , which correlates with premature exhaustion of stem cells.
In this context , palliative care programs are needed more frequently.
In this context , physicians might include PET as a tool for exercise prescriptions for the elderly.
In this context , poor memory may affect decision quality , particularly in individuals with memory decline , such as older adults.
In this context , principles of regenerative science are increasingly integrated in rehabilitation practices as illustrated in the present Supplement.
In this context , recent longitudinal studies of higher level of evidence have been conducted to assess the link between AF and dementia.
In this context , TGFbeta @number@ appears as a major player in the osteolytic process that affects mandibuloacral dysplasia type A patients.
In this context , the causes of gender differences in stroke prevalence and outcome and the obesity-stroke paradox should be further investigated in future studies.
In this context , the development of single multitargeted therapeutics directed against two or more disease mechanisms could be advantageous.
In this context , the FA index presented here provides answers to two questions.
In this context , the main risk factor in elderly patients , ie , frailty syndrome , gains special importance.
In this context , the mechanisms of action of adaptogens are specifically related to stress-protective activity and increased adaptability of the organism.
In this context , the present work provides an overview of the most recent advances in the field of synthetic bone grafts.
In this context , the research of naturally occurring anti-aging agents is greatly expanding and in recent years numerous plant-derived products have been investigated.
In this context , these diseases can be considered as metabolic retinal diseases.
In this context , we review new literature supporting the original aging framework , and its extrapolation to chronic TBI.
In this contribution , a new concept for an activity recorder and transceiver ( ART ) is presented.
In this contribution , we aimed to analyze how alternative modular descriptions could condition the outcome of follow-up network biology analysis.
In this contribution , we report the first fluorescent probe-ThiolQuant Green ( TQ Green ) -for quantitative imaging of GSH in live cells.
In this cross-sectional analysis , directionality cannot be determined.
In this cross-sectional study , @number@ healthy females ( aged 18-50 years ) were included.
In this cross-sectional study , we estimated the age-related change in toe flexor strength and compared it with that of handgrip strength.
In this descriptive cross-sectional study patients who were visited in Sina Hospital in Tabriz and had confirmed tinea corporis with direct fungal smear were selected.
In this discourse focus was on depicting volunteers and enhancing the importance of volunteer work.
In this document vital demands on such systems will be defined and systematically analyzed.
In this document we will review the state of knowledge on this topic and discuss the challenges of multidisciplinary asthma management in the elderly.
In this elderly cohort , short and long telomeres were associated with increased risk of aMCI.
In this evaluator-blind , placebo-controlled study , microinjections of stabilized hyaluronic acid ( HA ) gel for rejuvenation of aging hands were evaluated.
In this experiment , however , the participants ' abilities to discriminate grating orientation and speed were also assessed.
In this exploratory study , we examined the neural correlates of affective and cognitive empathy in older adults.
In this Extra View article , we extend our analysis to other members of the heat shock protein family.
In this eye-tracking study , we tested age differences in visual attention and emotional reactivity , using standardized emotionally negative stimuli.
In this far-reaching review , we examine what is currently known about ALS genetics and how these genes were initially identified.
In this framework , an overview of the main technological axes and challenges around connected health technologies in chronic disease management are presented and discussed.
In this framework , findings inferred from the performance literature suggest that increased protein intake may be beneficial.
In this group carotid ultrasound examination ( B-Mode imaging ) was performed and mean max IMT was calculated.
In this group of HIV + individuals over @number@ WMH burden was associated with cardiovascular risk and both worse diffusion MRI and cognition.
In this group of participants , there was an increase in sleep disturbances following retirement.
In this group of patients medication may play a role.
In this group , the age ranged from @number@ to @number@ years , with a mean age of @number@ years ( SD± @number@ ) .
In this group , the predictive positive value of biopsy was @percent@ ( 32 / 100 ) .
In this hypothesis , integration with a larger network system would be necessary.
In this introduction , we outline current goals and approaches that will be described in more detail elsewhere in this issue.
In this investigation , knee injury was induced in mice by compressive loading.
In this investigation the effect of education differs with group.
In this investigation , the healthy life expectancy in adult older population with social security in Mexico is estimated.
In this investigation , we examined whether the same neural regions support this memory benefit in both age groups.
In this issue , Hammers et al. report the first longitudinal study of B-cell responses in pemphigus vulgaris.
In this issue of Cell Metabolism , Park et al.
In this issue of Cell Metabolism , Scheibye-Knudsen et al.
In this issue of Cell Stem Cell , Crews et al.
In this issue of Cell Stem Cell , Saini et al.
In this issue of Immunity , Krasemann et al.
In this issue of Molecular Cell , Kim et al.
In this issue of Neurobiology of Aging , Ryu et al. uncover the impact of autophagy on the potential toxicity of mutant FUS-positive stress granules.
In this issue of Neuron , Gasset-Rosa et al.
In this issue of Neuron , Tufail et al. present an underlying mechanism for microglia-mediated elimination of virally transduced cells in the central nervous system.
In this issue , Yamashita et al.
In this large autopsy study LVD was associated with cortical and hippocampal atrophy.
In this large study , we show that PD patients are about one-third less active compared to controls.
In this latter case , multimorbidity had more prognostic capability in men than in women.
In this latter context , the current state of research in the AD area is reviewed together with necessary priorities in moving forward.
In this light historical demographic data may be very useful for identifying lineages in human populations that are worth investigating further by geneticists.
In this line , administration of spermidine rescued α-synuclein-induced loss of dopaminergic neurons , a hallmark of PD , in nematodes.
In this line , digital electroencephalography ( EEG ) allows noninvasive analysis of cortical neuronal synchronization , as revealed by resting state brain rhythms.
In this literature review , we aim to answer whether this is effective.
In this literature , this obesity subphenotype is therefore referred to as metabolically healthy obesity ( MHO ) .
In this manner , oncology nurses can assist their patients to maximize QOL while living with this challenging illness.
In this manner , WRAP53β controls proper ubiquitylation at DNA damage sites and the downstream assembly of 53BP1 , BRCA1 , and RAD51.
In this manual , intramuscular injection of testosterone enanthate or human chorionic gonadotropin and the testosterone gel ' Glowmin ' were recommended as TRT.
In this manuscript laser resurfacing and laser therapy of vascular and pigmented lesions of aging skin will be overviewed.
In this manuscript , the senior author reviews his experience with the endoscopic forehead lift and delineates a stepwise approach to this technically challenging operation.
In this method , rats either received NTF4 either systemically via osmotic pump or by direct injection through the vocal folds.
In this mini-review , we characterize the changing epidemiology of HIV-related chronic kidney disease in Western nations and in sub-Saharan Africa.
In this mini-review , we discuss recent progress in the use of antioxidants , anti-inflammatories and apoptosis inhibitors to enhance hair cell survival.
In this minireview , we focus on five major epigenetic regulators and discuss their central role in cardiac fibrogenesis.
In this mode , autophagy suppresses inflammation to protect the kidney.
In this model , compromised protein degradation caused by Mg132 lead to elevated histone labelling.
In this model , deficits in hippocampal synaptic transmission and long-term potentiation ( LTP ) were observed.
In this modelled age range , an increase of flow rate per volume was observed , albeit at very slow rate.
In this model , MDD is characterized by a surfeit of potentially destructive mediators and an insufficiency of protective or restorative ones.
In this model , NHEJ repair of DSBs generated by the site-specific endonuclease , I-SceI , reconstitutes a functional GFP gene.
In this model , @percent@ of females aged 71 + years did not meet the estimated average requirement for protein.
In this model , somatic signals are considered to reflect both intra-individual processes and individual-environment interactions.
In this model , testosterone worsened and estradiol improved ARVC / D-related pathologies such as cardiomyocyte apoptosis and lipogenesis , strongly supporting our clinical findings.
In this model , the eye fissure represents a painting , and the most peripheral shadows around it represent the frame of this painting.
In this model , tumor killing required CD80 expression by tumor-associated phagocytes to trigger cytotoxic T cell activation.
In this monkey , the cell cycle of fibroblasts at early passage was significantly extended as compared to a normal control.
In this month's Editorial , Guest Editors Carol Brayne and Bruce Miller discuss research and commentary published in March and future directions for dementia research.
In this network , task-related connectivity was increased compared with young subjects , and the degree of connectivity was related to memory performance.
In this note we explain by an example what we understand by a balance situation and by a balance equation in terms of measures.
In this observational study , 24-hr accelerometer data ( ActivPal ) were collected from inclusion to discharge in @number@ patients at an acute geriatric ward.
In this observational study , @number@ consecutive patients with lung cancer underwent CPET with completed data over a 9-yr period ( 2001-2009 ) .
In this online study , we examined whether autobiographical memories from adolescence and early adulthood are recollected more than memories from other lifetime periods.
In this opinion piece , we attempt to answer three key questions concerning C9ORF72.
In this opinion piece , we critically discuss gene-environment interactions and attempt to answer three key questions.
In this Opinion we propose a novel framework where middle-age is accompanied by increased mitochondrial activity that subsequently declines at advanced ages.
In this paper , a first sensing strategy for protein glycation is proposed , based on protein electroactivity measurement.
In this paper , an inventory of activities was made that threaten independent living of elderly when becoming problematic.
In this paper , a recording and analysis system is designed and developed for outdoor activity patterns characterization.
In this paper a review of this research is first presented.
In this paper experimental gerontology in Italy is reviewed on the basis of research developed in Academic and non Academic Centres.
In this paper , for the first time we analyze the variations of human DNA and face simultaneously.
In this paper , I review the epidemiology of elder abuse as well as key practical issues in dealing with the cases of elder abuse.
In this paper , I review work examining the cognitive underpinnings of behavioral distraction by deviant sounds and highlight some of its key determinants.
In this paper , it is argued that frailty is a chronic condition and thus requires a chronic disease management approach.
In this paper , I will argue that there is a deep connection between home-based care , technology , and the self.
In this paper , I will present a reading of senior life through the lens of postcolonial theory.
In this paper , @number@ healthy subjects in two age groups have produced rapid handwriting strokes with a direction reversal.
In this paper , our determination of crystal structures of oxidized Pin1 reveals a series of Pin1 oxidative modifications on Cys113 in a sequential fashion.
In this paper the allostasis principle is applied to the oral ecosystem.
In this paper , the authors analyze data from the LEAP Study to illustrate the methods and benefits of inverse intensity weighting in GLMs.
In this paper , the authors present a brief personal account of the senior author's @number@ years of exploration in behavioral gerontology.
In this paper , the authors provide a policy prescription for Canada's aging population.
In this paper , the definitions , criteria , pathologies , subtypes and genetic markers for the most common age-related major NCD subtypes are summarized.
In this paper , the development of hypoxia-selective prodrugs , HIF-1 inhibitors , and modulators of the tumor microenvironment will be discussed.
In this paper the laboratory and clinical reliability of the two active subretinal implants Alpha IMS and Alpha AMS is presented.
In this paper , the moderating effect of resilience in the relationship between SLEs and depressive symptomatology in older Chinese adults is investigated.
In this paper , the most important results of these case studies will be discussed.
In this paper , we are evaluating UWB receivers based on the IEEE @number@ physical layer definitions and capable of detecting differentially encoded modulation.
In this paper , we constructed a new DTI atlas , which contains the complete diffusion tensor information in ICBM152 coordinates.
In this paper we describe a method for the determination of the amount of amino acid left after reaction with well known fingerprint visualization reagents.
In this paper , we describe holistic approaches for prevention and treatment of frailty and sarcopenia.
In this paper , we develop a novel mathematical framework to study the processes of cancer initiation.
In this paper , we developed and tested a material that will enable concurrent measurement of two-dimensional surface electromyograms ( EMGs ) with US images.
In this paper , we discuss the role of AGE-RAGE-oxidative stress and its therapeutic interventions in osteo-vascular disorders.
In this paper , we discuss the various metrics that can be used to understand the process of aging from a complexity science perspective.
In this paper we draw attention to the positive and negative effects of a general imperative to contribute.
In this paper , we examine barriers to the integration of refugee doctors and nurses in Canada and the United Kingdom.
In this paper , we examined the age-related changes in control of preprogramed movement , with emphasis on its accuracy.
In this paper , we explore the potential of the technique to classify transcribed speech samples along clinical dimensions , using vocabulary data alone.
In this paper , we highlight qualitative research on dementia involving people living with dementia as active participants.
In this paper we highlight the role of resource transfers and non-material assistance within and across generations in shaping low human mortality rates.
In this paper , we investigated whether / how encoding intentionality affects the retention of target and contextual episodic information from a novel experience.
In this paper , we investigate how the lithium dose-concentration ratio changes across the lifespan.
In this paper , we investigate the use of Non-Negative Matrix Factorization ( NNMF ) for the analysis of structural neuroimaging data.
In this paper , we'll outline prevention , treatment and control of arteriosclerosis from a perspective of antiinflammation.
In this paper , we model multivariate time-to-event data by composite likelihood of pairwise frailty likelihoods and marginal hazards using natural cubic splines.
In this paper , we present a method of detecting drusen in retinal fundus images.
In this paper , we present a multi-user engagement-based robotic coach system architecture ( ROCARE ) .
In this paper , we present a unified wavelet framework that links Hyper-SPHARM to the diffusion wavelet transform.
In this paper we present how to design and implement a low-cost system for reliable fall detection with very low false alarm ratio.
In this paper , we present key findings from the AIBL study and discuss how they contribute to our understanding of AD pathogenesis and diagnosis.
In this paper we propose a framework for detecting health patterns based on non-wearable sensor sequence similarity and natural language processing ( NLP ) .
In this paper , we propose an adequacy evaluation method by applying fuzzy inference.
In this paper we propose a new methodology that combine advanced techniques of effective connectivity estimation , graph theoretical approach and classification by SVM method.
In this paper , we propose a two-stage method for the statistical analysis of longitudinal shape.
In this paper , we report @number@ successful cases of valvular surgeries in which axillary artery cannulation was used to avoid complications of brain.
In this paper , we report US national incidence rates for dementia and CIND.
In this paper , we reviewed several mechanisms by which insulin may affect pathophysiology in AD.
In this paper , we reviewed the functions of statins in bone metabolism and anti-inflammation in periodontitis.
In this paper , we reviewed this literature using a systematic three-step extraction procedure plus a quality evaluation assessment for each retained article.
In this paper , we review patents in which resveratrol glucosides are specifically involved in immunological activity in humans.
In this paper , we review studies investigating the effects of meditation on age-related cognitive decline.
In this paper , we review the current understanding of the mechanisms leading to tissue-specific adult stem cell dysfunction and reduced regenerative capacity with age.
In this paper we review the effects of aging on sensory systems and their impact on posture , balance and gait.
In this paper , we review the literature on AFB and CVD events and mortality.
In this paper , we review the pathophysiological role of the AGE-RAGE-oxidative stress system and its therapeutic intervention in vascular damage in diabetes.
In this paper , we review the pathophysiology of HFrEF , discuss already established and novel evidenced-based pharmacologic therapies available for these patients.
In this paper , we review the recent advances in understanding the diminished CD8 T cell immune response to influenza virus infection in aged mice.
In this paper , we show that in addition to appearance information , facial dynamics can be leveraged in age estimation.
In this paper we study the prevalence and risk factors for multiple spine surgery and its impact on cost.
In this paper , we summarize the essential role of soluble Aβ oligomers in AD and discuss therapeutic strategies that target soluble Aβ oligomers.
In this paper , we survey the complete state-of-the-art techniques in the face image-based age synthesis and estimation topics.
In this paper we test the ' red herring ' hypothesis for expenditures on long-term care ( LTC ) .
In this paper , we will explore recent findings regarding diverse single nucleotide polymorphisms from GWAS on T2DM , AD and both.
In this paper we will review the unique antioxidant activity of resveratrol including its effects on mitochondrial function.
In this pathogenic condition , we find that FOXO inhibition has protective effects , suggesting that this transcription factor ultimately contributes to neuronal cell death.
In this pathway , pink1 functions upstream of parkin to regulate mitochondrial fission / fusion dynamics and normal mitochondrial function.
In this patient population , obinutuzumab was superior to rituximab when each was combined with chlorambucil.
In this perspective article , the current and potential opportunities for the successful delivery and differentiation of new inhaled drug products are discussed.
In this perspective , it is possible to speculate on the presence of a mirror relationship between depressive and cognitive disorders in late-life.
In this perspective , the health of older PLWHA must be viewed through a lens of power and strength rather than one of deficit.
In this perspective , we critically review these and other findings , leading us to conclude that our original model requires modification but not revision.
In this phenomenological study , @number@ community-dwelling older adults were recruited using purposive and snowball sampling at community locations.
In this pilot study , ablative fractional resurfacing was safe and effective for the treatment of all markers of extrinsic aging of the hands.
In this pilot study , we attempt to determine whether smoking cessation reduces biological age.
In this pilot study we characterized immune changes associated with the IRP in a sample of successfully treated HIV-infected subjects.
In this pilot study , we recruited @number@ elderly adults with or without concurrent cognitive stimulations to attend a memory-training program.
In this population , age and refraction did not affect CCT.
In this population-based sample , individuals with SMC had evidence of impairments on specific neuropsychological testing which might not be apparent on global measures.
In this population , men are more likely to be successful in increasing physical activity.
In this population , @number@ patients were using anti-osteoporotic medication and @number@ patients were using preventive supplements.
In this population , @number@ subjects were identified as having diabetes on @date@ .
In this population , the decline of multiple physiologic processes and diseases collectively influence treatment options.
In this population , training-induced cognitive plasticity has rarely been studied.
In this population , we investigated spatial distribution of microbleeds and whether this is influenced by APOE genotype.
In this preliminary study , we sought to identify structural and functional brain differences associated with financial exploitation in older adults.
In this presentation , we demonstrate the radiological imaging findings of skeletal , oral and craniofacial phenotypes of abnormalities associated with HGPS.
In this presentation , we would like to explain the efficient application of biochemical markers and rapid physiological tests for the pathological diagnosis of atherosclerosis.
In this presymptomatic stage when no cognitive impairment is present , AD biomarkers and HTN have additive effects on gray matter damage.
In this project , a computational model was developed to study the sutural fluid inflow of the aging human lens.
In this project we found that the patient's age determines the frequency of intraperitoneal metastases of ovarian cancer.
In this prospective cohort study @number@ patients older than @number@ years ( @percent@ female , @percent@ male ) who received THR were included.
In this prospective observational study , we aimed to assess the multidimensional aspects of asthma in the elderly.
In this prospective study , it was investigated whether these findings could be confirmed in the oldest old.
In this protocol we describe a method to obtain telomere length parameters using Southern blots of terminal restriction fragments ( TRFs ) .
In this protocol we explain how to use the GeneNetwork web service , a powerful and free online resource for systems genetics.
In this qualitative review , we summarize recent findings on genetic factors linked to longevity across different populations and study designs.
In this randomized trial , a switch to RAL did not significantly affect urinary eicosanoids over @number@ weeks.
In this regard , a neurofeedback training ( NFT ) tool using motor imagery-based BCI , was developed.
In this regard , atopy has rarely been considered in the clinical assessment of the geriatric respiratory patient.
In this regard , cumulative data have demonstrated that polyphenols can display neuroprotective effects through different mechanisms.
In this regard , identifying the molecular mechanisms that modulate adipocyte fat accumulation and fatty acid spillover is imperative.
In this regard , it has been previously reported that relative to young controls , seniors show delays in attention-related sensory facilitation.
In this regard , queuing appears to offer some potential for investigating how deficits originate and accumulate.
In this regard , recent studies have demonstrated that telomeres in iPS cells may be rejuvenated.
In this regard , regular exercise training affords some protection but does not completely override age-related defects.
In this regard , tears could be considered an optimum material obtained by noninvasive procedures.
In this regard , the AABFC immobilizes ARMs from the blood while blood passes through the column.
In this regard , the additional supply with vitamins of children in pre-school and middle-school period is essential.
In this regard , the bulge niche of the mammalian hair follicle offers an excellent model for study.
In this regard , TP53INP2 activates autophagy in skeletal muscle , thus causing a reduction in muscle mass.
In this regard , Turkish immigrants in particular have the poorest utilization of HPC.
In this regard , we investigated the possible impact of the three different human ApoE isoforms on neurogenesis.
In this regard , we postulate that adoptively transferred AMSCs could augment dendritic cell functions in aged mice.
In this regard we will particularly focus on the use of topical antioxidants and the challenges that result from the task of showing their efficacy.
In this region , diagnosis accuracy was better than the HV , especially at prodromal stage.
In this report , a novel role of CEBPD in attenuating macrophage-mediated phagocytosis of damaged neuron cells was found.
In this report , basic evaluation of N170 in presenting numerical images which had different contrasts was performed.
In this report , we describe a novel mechanism by which cells become resistant to TGF-β-mediated growth suppression.
In this report , we describe our clinical results and problems of continuous-flow LVAD and discuss the future strategy for heart failure patients.
In this report , we describe the case of an 83-year-old patient with severe systolic heart failure complicated by aortic valve stenosis and atrial fibrillation.
In this report , we discuss epidemiologic and clinical evidence suggesting that sleep apnea is involved in the pathogenesis of altered glucose metabolism.
In this report , we examined the association between age at puberty and prodromal symptoms of psychosis.
In this report , we have found direct evidence on the higher survival of the HbF rich erythrocytes in SCD.
In this report , we identified miR-127 as a novel regulator of cellular senescence that directly targets BCL6.
In this report , we present the homology and differences in IIS pathway of various organisms including worm , fly , rodent and human.
In this report , we provide an interpretation of our new treatment strategy which involves controlling histone methylation.
In this report , we studied epigenetic mechanisms involving histone modifications that confer apoptosis resistance to senescent human diploid fibroblasts ( HDFs ) .
In this report we studied S1R-mediated BDNF release from human astrocytic glial cells.
In this report , we study glycated histones and its in vitro oxidation.
In this report , we summarize our recent findings in relation to survival.
In this Research Perspective we will explore some of the implications this recent work has for human health.
In this research , the anti-amyloidogenic activity of three carotenoids , cryptocapsin , cryptocapsin-5 , 6-epoxide , and zeaxanthin , was assessed.
In this research , the confounding effect of occupant age in a vehicle in terms of seat position and seatbelt use was investigated.
In this respect , metabolic interventions can be viewed as promising strategies to promote longevity and to prevent or delay age-related disorders including cancer.
In this respect , nanoscience-based systems are expected to provide more efficient mitigation of oxidative stress.
In this respect , neurons in layer II of the entorhinal cortex are selectively vulnerable in aging and Alzheimer's disease ( AD ) .
In this respect , oncological rehabilitation has an important supporting function.
In this respect , work from our group and others suggest that H3.3 plays an important function in age-related processes throughout evolution.
In this review , an attempt is made to summarize the current knowledge on how the immune system is affected by the aging process.
In this review are provided summarized literature data on this matter.
In this review article , some interesting observations are presented , possibly contributing to the future practice of forensic pathologists.
In this review article the effects of aging on the mitochondrion- , receptor- , and p53-mediated apoptotic pathways in skeletal muscle are discussed.
In this review article , we present the novel use of exogenous DNA repair enzymes and describe their role in combating photocarcinogenesis and photoaging.
In this review , criteria for diagnosing diabetes and recommendations for screening are described.
In this review , differences and similarities of AMD and AD are thoroughly discussed.
In this review , efforts have been made to summarize the biomarkers that have been reported in recent studies on patients.
In this review , evidence implying rapamycin and TOR in aging / life span extension and memory improvement will be discussed.
In this review , evidence of resveratrol's anti-tumor effects and molecular mechanisms are recapitulated.
In this review , experimental studies on thymic atrophy in rodents and clinical cases where the thymus atrophies are discussed.
In this review , factors that contribute to chronic inflammation are discussed.
In this review , hospitalization rates for gastroenterological disorders in England are presented by age to demonstrate gradients with age.
In this review , I discuss the fact that microRNAs have the potential to determine significantly the spectrum of phenotypic plasticity by regulating translation rate.
In this review I have discussed various mechanisms , which may be responsible for impaired functions of DCs.
In this review , information on the soft tissue augmentation method using the injectable tissue-engineered soft tissue is provided.
In this review I will examine the various mechanisms how Galectin @number@ supports chemoresistance and metastasis in solid tumors and in leukemia and lymphoma.
In this review , only spontaneous protein modifications such as deamidation , oxidation , nitration glycation and carbamylation are reviewed and discussed.
In this review paper , we specifically focused on multimodal neuroimaging studies on cognition , aging , disease and behavior.
In this review recent data on gastric changes during ageing , focussing especially on histological modifications and motility disorders are summarized.
In this review , recent developments in the characterization of DNMT3A were discussed with special emphasis on the roles of DNMT3A in development and cancer.
In this review , sex and aging are analyzed as phenoptotic phenomena , and the similarities between them are investigated.
In this review special attention was dedicated to diseases related to age as atherosclerosis , cancer and Alzheimer disease.
In this review , the authors describe the epidemiology , pathophysiology and outcome of the different therapies of AF in this specific patient population.
In this review , the authors discuss in detail the clinical implications of the melanopsin system.
In this review , the authors discuss the association of DED with various psychiatric and neurological disorders.
In this review , the current approaches using microRNAs as novel diagnostic and therapeutic strategies for cardiac remodeling and heart failure are highlighted.
In this review , the current knowledge of the cancer-related mechanisms in relation to the modulatory effects of microRNA-34 family were analysed.
In this review , the effect of ESRD on the adaptive cellular immune system is discussed.
In this review , the focus will be placed on the effects of green tea catechins in neuronal mitochondria.
In this review , the human evidence that telomere length is a biomarker of aging is evaluated.
In this review the involvement of the ubiquitin-proteasome pathway in protein degradation at different levels of cellular life is discussed in relation with ageing.
In this review the main topic is to mention new or alternative ways of photoprotection.
In this review , the mechanisms of cell death / survival signaling pathways after ischemia and the potential therapeutic targets will be discussed.
In this review , the nature of the ganglioside clusters and how gangliosides behave in the clusters leading to the GAβ generation are discussed.
In this review , the organ-protective and anti-inflammatory effects of resveratrol in trauma-hemorrhagic injury will be discussed.
In this review , the participation of the BBB in the amyloid cascade and in other mechanisms of AD neurodegeneration will be discussed.
In this review , the possible role of docosahexaenoic acid ( DHA ) in the prevention of age-related disruption of brain function is discussed.
In this review , the prevalence , potential biological mechanisms , and the clinical relevance of MHO are discussed.
In this review , the principles of posterior cardiac restoration therapy will be discussed.
In this review , the RANK / RANKL / OPG pathway is described.
In this review , the relationship between uremic inflammation and a premature aging phenotype , as well as potential causes and consequences , are discussed.
In this review , the results of the selected studies are summarized and compared.
In this review , the retinal functional hyperemia response is described , and the cellular mechanisms that may mediate the response are assessed.
In this review , the role and function of chronic inflammation in aging and aging-related diseases will be summarized.
In this review , the ROS-producing enzymes , as well as the antioxidative defense system in mammalian peroxisomes , are described.
In this review , these observations are re-evaluated in light of contemporary evidence.
In this review , we address age-related muscle loss and the risk factors of mortality , emphasizing the need for early diagnosis and intervention.
In this review , we address microglia functions with respect to determining factors , phenotypic presentations , adaptation to environmental signals and aging.
In this review , we address recent progress towards understanding the putative role and complexities of stem cells in the development of BPH and PCa.
In this review , we aimed to show the relationship between diet , nutrient sensing pathways and microRNAs in the context of aging.
In this review , we aim to describe the link between PD-related genes , which are involved in mitochondrial function , and deleterious neuroinflammation.
In this review , we aim to synthesize the mechanisms that drive hippocampal aging and evaluate critically the potential for rejuvenation.
In this review , we amass and discuss the recent data related to age-associated genes in MSCs.
In this review , we analyze data on the functional effects of signals from the innate immune system on dopaminergic differentiation , survival and proliferation.
In this review , we analyze four microarrays related to three neurodegenerative diseases.
In this review , we analyze in detail the epidemiology , prevention and costs originated by CVD.
In this review , we argue that relevant information can be derived from studying normal , aging animals performing hippocampal-sensitive tasks.
In this review , we assess the existing and potential application of using telomeres for age estimation.
In this review , we attempt to elucidate the role of MMPs in neurodegeneration and their functional mechanism in repairing the CNS.
In this review , we briefly summarise the effects of ageing on oocyte quality.
In this review , we comment on current AD biomarkers in cerebrospinal fluid and in blood.
In this review , we consider changes in architecture , porosity , and composition , including collagen structure , mineral composition , and crystal size.
In this review , we consider methodological advances with particular relevance to the role of WM in age-related changes in processing speed.
In this review we consider the mechanisms of ageing and the associated changes in lipid metabolism according to gender.
In this review , we converged the data of genetic and clinical investigations to identify the clearer role of TREMs in AD.
In this review , we critically discuss the main paths to AD prevention through control of modifiable risk factors and lifestyle changes.
In this review , we demonstrate how ageing affects various mitochondria-associated pathways and their response to a variety of factors.
In this review we describe changes in the ageing liver and discuss mechanisms of senescence at the cellular level.
In this review , we describe current research that links aging to chromatin structure.
In this review , we described clinical characteristics of stroke in elderly people with diabetes.
In this review , we described determinants of bone quality and strength.
In this review we described the main components of the TOR pathway and its upstream effectors and downstream processes in relation to aging.
In this review , we describe NSCs and their niches during tissue homeostasis and how they undergo age-associated remodeling and dysfunction.
In this review , we describe recent studies focused on the regulatory role of each type of nutrient in aging.
In this review , we describe the best characterized aging pathways and highlight the role of epigenetics in diet-mediated longevity.
In this review , we describe the current status in our understanding of these transcriptomes through the use of high-throughput techniques.
In this review , we describe the epidemiology , clinical characteristics , and clinical management of patients with PD in LTC settings.
In this review we describe the fundamental steps of DHEA physiological secretion and its peripheral metabolism.
In this review , we describe the mechanisms of transcriptional regulation for the known AD genes and the misregualtion that leads to AD susceptibility.
In this review , we describe the various possibilities of treatment for localized or metastatic BC in an aging population.
In this review , we discuss clinical features of subclinical hypothyroidism in the elderly.
In this review , we discuss different imaging modalities that are currently being considered or used for screening AMD.
In this review we discuss endogenous protective mechanisms , including angiogenesis and vasculogenesis , and underlying molecular mechanisms.
In this review , we discuss exciting new insights into stem cell aging and proteostasis and the questions raised by these findings.
In this review , we discuss how miRNAs regulate EC function and vascular inflammation in response to a variety of pathophysiologic stimuli.
In this review , we discuss NGS-based genome-wide approaches that can provide deeper insights into retinal development , aging and disease pathogenesis.
In this review , we discuss pharmaceutical BACE1 inhibition as a therapeutic option for axonal pathogenesis , in addition to amyloid pathology.
In this review , we discuss previous studies that describe the estrogen- and testosterone-dependent actions on the mitochondrial processes implicated in aging.
In this review , we discuss progress in these areas and highlight emerging concepts in NTF biology and therapy.
In this review , we discuss recent progress in understanding the contribution of these transcription factors to macroautophagy regulation in the context of aging.
In this review , we discuss some points and techniques that need to be borne in mind to increase the chances of successful USPCB.
In this review , we discuss such mechanisms.
In this review we discuss the biology of C. elegans and mammals in the context of aging and age-dependent diseases.
In this review , we discuss the causes and mechanisms of vascular aging at the tissue and cellular level.
In this review we discuss the current understanding of immune cell function in both diet-induced and age-related obesity.
In this review , we discuss the emergence of many novel , diverse and rapidly expanding classes and subclasses of short and long ncRNAs.
In this review , we discuss the emerging evidence in favor of genetic players in MSA.
In this review , we discuss the epidemiology and risk factors for PJIs among older adults.
In this review we discuss the evidence for ageing-induced neuronal dysfunction that might predispose to neurogenic forms of incontinence in the elderly.
In this review , we discuss the evidence for the roles of HDACs in cognitive function as well as in neurological disorders and disease.
In this review , we discuss the evidence linking arterial stiffness , hypertension and brain structural abnormalities in older adults.
In this review we discuss the evidence of transgenerational epigenetic inheritance of stress exposure in human studies and animal models.
In this review , we discuss the findings of adipose p53 and Rb-two central molecular linkages between aging and obesity-on lipid metabolism and obesity.
In this review , we discuss the influence of these regulators on alternative splicing , mRNA stability and translation.
In this Review , we discuss the literature investigating the association of cardiovascular burden with cognitive decline and dementia over the life-course.
In this review , we discuss the molecular control of autophagy , focusing particularly on the regulation of physiologic vs. defective autophagy.
In this review , we discuss the nature and impact of most relevant confounders.
In this review , we discuss the pathogenesis of age-related neurodegenerative diseases including Alzheimer's disease , Parkinson's disease and cerebrovascular disease.
In this review , we discuss the process of aging and rejuvenation as systemic events.
In this review we discuss the recent development in understanding how Wip1 contributes to tumorigenesis with its relevance to breast cancer.
In this review , we discuss the roles of an evolutionarily conserved histone chaperone known as the HIR / HIRA complex.
In this review , we discuss the specific roles of each HDAC protein and the possible function of distinct histone modifications.
In this review , we discuss type @number@ and type @number@ photochemical damage that occurs in response to UV exposure.
In this review , we draw attention to the fundamental roles played by epigenetic mechanisms in transcriptional and post-transcriptional regulation within the circadian clock system.
In this review , we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations.
In this review , we examined current literature to identify gaps and inform future research priorities on ST and healthy ageing.
In this review , we examined the evidence for effects of music-based interventions as a treatment.
In this review we examine the connections between CR , T ( b ) and mechanisms that influence longevity and ageing.
In this review we examine the data linking epigenetic alterations in the prostate with aging to cancer development.
In this review , we examine the epidemiology , risk factors , etiologies , and potential consequences of multimorbidity in aging HIV-infected persons.
In this review we examine the role of mitochondrial dysfunction and mtDNA mutations in cell aging and senescence.
In this review we examine these diseases , some caused by mutations in the LMNA gene , and their skin disease features.
In this review , we explore common and divergent biological forces tilting the lung homeostatic balance away from health and toward emphysema or pulmonary fibrosis.
In this review , we explore existing and emerging paradigms in the pathogenesis of IPF in light of the recently defined hallmarks of aging.
In this review , we explore recently developed non-viral gene carriers based on reducible systems specialized to target the cytoplasm , nucleus and mitochondria.
In this review , we explore the cellular and molecular basis of these defects and their possible clinical implications.
In this review , we first discuss the cellular hierarchy of the hematopoietic system and the components that make up the surrounding hematopoietic niche.
In this review , we first introduce the method of EEG microstate analysis.
In this review , we first present basic background information on AMPK and fibrogenesis and describe the protective roles of AMPK in three fibrogenic phases.
In this review we focus on demonstrating the TET proteins in DNA demethylation and transcriptional regulation of different target genes.
In this review , we focus on how nature and nurture modulate peroxisome biogenesis and function in mammalian cells.
In this review , we focus on interactions between BS and FA proteins that specifically occur during chromosome segregation in mitosis.
In this review we focus on pre-clinical and clinical studies using polycation-based nanocarriers for RNAi mediated anti-cancer intervention after intratumoural or intravenous administration.
In this review , we focus on preclinical late-life intervention studies , which assess the relationship between physical function , sarcopenia , and body composition.
In this review , we focus on the central role of mitochondria in ARHL.
In this review , we focus on the major age-related changes that occur in the naïve and the antigen-experienced T cell population.
In this review we focus on the pathogenesis of HIV-induced immunosenescence and on the clinical management of older HIV-infected patients.
In this review , we focus on the prospective applications of different stem cell types for disease modeling and drug screening.
In this review , we focus on the relationship between the UPS function and aging as well as Huntington disease.
In this review , we focus on the role of autophagy as an alternative source of cellular energy , particularly important when nutrients are scarce.
In this review , we focus on the role played by oxidative stress and cardiolipin in mitochondrial bioenergetic alterations associated with brain aging.
In this review , we focus on these @number@ areas and investigate the solutions and problems addressed by previous research.
In this review , we have enumerated six distinct functions of microglia and discuss the specific effects of both aging and AD.
In this review , we have summarized the literature related to the concept of early aging in schizophrenia.
In this review , we highlight pathogenic changes that destabilize ocular homeostasis and promote AMD development.
In this review , we highlight relevant pathophysiological aspects and discuss currently used therapeutic strategies for neuropathic pain.
In this review , we highlight resilience factors that appear to have a beneficial relationship with health outcomes.
In this review , we highlight some of the pathophysiological mechanisms that characterize the vascular aging phenotype.
In this review , we highlight some recent advances in vitamin D researches and clinical trails.
In this review , we highlight the emergence of high-throughput aging approaches in the most commonly used model organisms.
In this review , we highlight the recent progress in the development of SLNs for disease treatment.
In this review we highlight the value of the yeast Saccharomyces cerevisiae as a model for PD.
In this review , we illustrate the action of androgen on the cardiovascular system , focusing on the action of testosterone on blood vessels.
In this review we included @number@ cross-sectional and four prospective longitudinal studies.
In this review , we intend to review and discuss the role of three surgical procedures in an office setting.
In this review , we outline the major advantages and limitations of current models and offer suggestions for how to move forward.
In this review , we outline the network perspective on healthy brain aging and discuss recent developments in this field.
In this review we present a general definition of adult SC niches in the most studied mammalian systems.
In this review , we present an overview of the current literature on the application of retinal imaging in the study of dementia and stroke.
In this review , we present an overview of the mechanisms unravelling sensing and transducing oxidative stress.
In this review , we present current opportunities of neuroimaging techniques in the diagnosis and differentiation of neurodegenerative disorders.
In this review we present the clinical , tissular and cellular characteristics of the nuclear envelope-linked lipodystrophies , as well as their hypothetical pathophysiological mechanisms.
In this review , we present the potential applications of nanotechnology toward prevention , identification and treatment of atherosclerosis.
In this review , we primarily focus on the latest signal webs and regulation mechanisms of the UPR.
In this review , we propose a positive feedback loop between CVD and amyloid deposition.
In this review we propose the activation of the co-agonist site of NMDA receptors as a target to remediate features of the age-related cognitive decline.
In this review , we provide a comprehensive discussion of the literature implicating each of the three members of the Gadd45 family in these processes.
In this review , we provide an overview of specialized quality control E3 ligases playing a critical role in the degradation of damaged proteins.
In this review , we provide an overview of the current laboratory and clinical status of CsA neuroprotection.
In this review , we provide an overview of the effects of Aβ in AD brains , especially focusing on synaptic dysfunction and microglia.
In this review , we provide an overview of the roles of CL in mitochondrial function and bioenergetics in health and disease.
In this review , we provide an overview on implications and therapeutic strategies of JNK in neurodegenerative disorders.
In this review , we provide an update on novel pathways and mechanisms regulated by ADP-ribosylation in organisms coming from all kingdoms of life.
In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.
In this review we provide brief overview of telomerase-deficient aging affects in diverse stem cells populations.
In this review we provide up-to-date information on treatment recommendations , and discuss recent case reports on fungal endocarditis and challenges in prophylaxis and treatment.
In this review , we report and discuss the role of micronutrients in cognitive impairment in relation to genomic stability in an aging population.
In this review we report the signs of aging in this particular region and the underlying anatomy.
In this review , we selectively present age-dependent changes in stem / progenitor cells that are vital for tissue homeostasis and repair.
In this review we sought to discuss the possible implication of SGK-1 in mechanisms regulating senescence and age-related diseases.
In this review , we sought to summarize for clinicians what is known about the molecular processes that causes disc degeneration.
In this review , we studied systematically whether there is a relationship between endothelial dysfunction and tendinopathy.
In this review we study age-related susceptibility to HF , as well as the utility and limitations of standard HF strategies.
In this review , we summarise key topics relating to gait measurement.
In this review , we summarise research findings and discuss important future challenges.
In this review , we summarize and interpret the latest basic research findings , as well as clinical observations , in respect of neuropathies.
In this review , we summarize available evidence on herbal medications mostly used in cardiovascular medicine.
In this review , we summarize current evidence for a direct effect of vitamin D on skeletal muscle.
In this review , we summarize current literature that is available on GA in elderly patients with solid malignancies who receive chemotherapy.
In this review we summarize data regarding , cardiovascular risk factors and vascular abnormalities , neuro- and vascular-inflammation , and brain endothelial dysfunction in AD.
In this review , we summarized our current understanding and hypotheses regarding oxidative stress and age-related dysregulation of cell death signalling pathways.
In this review , we summarize information about all genetically encoded redox indicators developed to date.
In this review , we summarize our current knowledge of mitophagy.
In this review , we summarize our current knowledge of the factors and mechanisms that modulate mammalian lncRNA stability.
In this review , we summarize our current understanding on the mechanisms regulating adiponectin multimerization.
In this review , we summarize potential mechanisms through which these hormones regulate satellite cells activation during skeletal muscle regeneration in the elderly.
In this review we summarize recent data showing that full disruption of TTDA expression in a knock-out mouse-model completely inactivates NER.
In this review , we summarize studies on ageing synapses in vertebrates and invertebrates , focusing on changes in morphology and ultrastructure.
In this review , we summarize the available evidence on the beneficial effects of behavioral interventions on sarcopenia.
In this review , we summarize the available literature on how women with diabetes experience ovarian aging , from menarche to menopause.
In this review , we summarize the contribution of epigenetic factors in the telomerase activation and discuss potential avenues to achieve therapeutic intervention in carcinoma.
In this review we summarize the current knowledge about in vivo LSCM of the ocular surface in glaucoma.
In this review , we summarize the current knowledge of lincRNA-p21 , mainly focus on the known biological functions and its underlying mechanisms.
In this Review , we summarize the current knowledge of the roles of lncRNAs in cardiac development and ageing.
In this review we summarize the current state of knowledge regarding age-related changes in autophagy in the heart.
In this review , we summarize the current state of the efforts to design potent and selective inhibitors against APE1 AP site incision activity.
In this review , we summarize the epidemiology of infections in this population and review studies that explore antibiotic use and prescribing patterns.
In this review , we summarize the fundamental role of the mechanistic target of rapamycin pathway in driving breast tumors.
In this review , we summarize the major findings from neuroimaging studies that link genetics with brain development , from infancy to young adulthood.
In this review , we summarize the multiple physiological roles played by sirtuins and their putative mechanisms , especially in cancer.
In this review , we summarize the pathophysiological and clinical evidence of the relationship between these two age-related disorders.
In this review , we summarize the roles of these factors , together with the understanding of the signaling pathways that regulate eye development.
In this review , we summarize these advances and discuss the latest progress in developing small molecule modulators.
In this review we summarize these findings.
In this review , we summarize the structural and functional alterations of WM in natural aging and speculate on the underlying mechanisms.
In this review , we summarize the systems biology data on AD and pay particular attention to the proteomic changes in AD.
In this review , we tried to sum up and discuss recent research achievements of autophagy in ovarian cancer.
In this review , we will address and discuss acute and chronic complications of SCD with a special focus on the older adult.
In this review we will analyze different surgical techniques.
In this review , we will analyze the hormonal causes , clinical relevance , and biologically relevant estrogen-modulated animal models potential for BOO study.
In this review , we will cover technical aspects of CE-MS coupling and highlight the improvements made in the last few years.
In this review , we will describe pathways contributing to the regulation of the age-related decline in mitochondrial function and their impact on longevity.
In this review , we will discuss biological processes of aging that predispose patients to AKI and CKD.
In this review , we will discuss findings regarding the OT effects on bone and fat mass.
In this review , we will discuss how altered ER homeostasis contributes to dysregulation of hepatic lipid metabolism and contributes to liver-associated metabolic diseases.
In this review , we will discuss how common cellular mechanisms that maintain tissue fidelity and organismal lifespan impact somatic stem cell function.
In this review , we will discuss how metal dyshomeostasis occurs in aging and Alzheimer's disease.
In this review , we will discuss literature and bioinformatic data describing the involvement of CNVs on PD pathobiology.
In this review , we will discuss recent findings in endothelial niche-mediated regulation of HSC function during development , aging and regenerative conditions.
In this review , we will discuss the mechanisms underlying the basis for abnormal phenotypes linked to mutations in genes encoding DNA helicases.
In this review we will discuss the mitochondrial dysfunction occurring in aging.
In this review , we will discuss the ways by which lamin genes are involved in the regulation of cell metabolism.
In this review we will emphasize its phenotype , metabolic and genetic particularities.
In this review , we will focus on age-related changes in oxidative capacity and flux measured in vivo in human skeletal muscle.
In this review , we will focus on both normal and malignant hematopoiesis , covering recent findings that illuminate the epigenetic life of HSCs.
In this review , we will focus on cellular senescence and COPD.
In this review , we will focus on the experimental and clinical evidence of PPAR agonists in a battle against the aging kidney.
In this review , we will highlight the recent evidence for neuronal hyperactivity before or during the onset of cognitive defects in mild cognitive impairment.
In this review , we will introduce the characteristic and age-related changes of MSCs.
In this review , we will present the mechanisms involved in autophagy , and those ensuring its tight regulation in skeletal muscle.
In this review , we will summarize findings identifying an emerging role of nucleolar stress for the onset and progression of in particular PD.
In this review , we will summarize the current knowledge of the rejuvenating effect of pregnancy on the mother.
In this review , we will summarize the strategies and the recent progress of research and development for the establishment of organ replacement regenerative therapies.
In this review we will systematically examine the alterations in the hemostatic components that occur during aging.
In this review , we would like to describe the transcriptional and epigenetic regulation during developmental and pathological stages.
In this revision , the target size for peripheral visual field measurements was changed from V / 4 to I / 4.
In this sample , @percent@ of subjects did not cover @percent@ of the dietary reference intake for protein.
In this sample , several indices extracted from the frontal and lateral photographs were closely correlated to their respective indices taken from the living individuals.
In this scenario , aspirin causes a chemopreventive effect by countering platelet activation which seems to play a role in early event in GI tumourigenesis.
In this scenario , mitochondrial function ( or dysfunction ) and mitochondrial DNA have emerged as major players.
In this second of @number@ manuscripts , data are presented on specific health care dimensions that contribute to the overall burden of skin disease.
In this sense , carotenoids are phytochemicals present mainly in fruits and vegetables with reported benefits for human health.
In this sense , it would be interesting to compare MDA concentration in tears from control subjects and from people with meibomian gland dysfunction.
In this sense nidogen-1 is essential to provide an anti-angiogenic environment of differentiated vessels.
In this series of healthy children , the fraction of CD34 + cells , CFU-GM colonies , and nucleated cells decreased with age.
In this setting , we explored the association between these gene variants and muscle strength.
In this situation , it has to be taken into account the germ cell association proposed in the present study to classify the stages.
In this situation , it is important to conduct clinical trials of drugs and use training methods to improve memory capacity.
In this small cohort , one third of individuals at @number@ % risk chose pre-symptomatic testing.
In this stage , the ovaries make less estrogen and progesterone.
In this state , elevated FSH is capable of maintaining relatively regular folliculogenesis and ovulation , but fertility is reduced.
In this study , a brain computer interface-based smart multimedia controller was proposed to select music in different situations according to the user's physiological state.
In this study , a child developmental delays e-screening system was developed.
In this study , ADSCs and BMSCs of the same donor were harvested and divided into two age groups.
In this study , aged human lens proteins were examined using HPLC-tandem mass spectrometry and a blind PTM search strategy.
In this study , all-cause mortality was assessed from baseline through Year @number@
In this study , a model was proposed that removes the increase for recent events from the temporal distribution.
In this study , amplicon sequencing of @number@ blood samples obtained from diseased dogs was used to measure methylation in seven DNA regions.
In this study , a Naïve Bayes-based method was proposed to predict antioxidant proteins using amino acid compositions and dipeptide compositions.
In this study , a new MVPA approach based on sparse representation has been employed to investigate the anatomical covariance patterns of normal aging.
In this study , an in silico modeling approach is taken to investigate the effects of mitochondrial fusion and fission dynamics on mutant mtDNA accumulation.
In this study , an MRI-compatible force platform was developed to simulate active balance control.
In this study , a simple and novel method for detection and distinction of large-scale prenylated peptides using mass spectrometry-cleavable approaches was developed.
In this study , As-MIF and hJAB1 were expressed and purified with high solubility.
In this study , a theoretical model of the transient viscous blood flow across the AS is derived by taking into account the aorta compliance.
In this study , a total of @number@ patients of the Endocrinology outpatient clinic who had undergone thyreopathy treatment of various lengths were investigated.
In this study , ATSC-Ex was topically applied on the cutaneous wound and healing speed was examined.
In this study , a vibro-ultrasound system was set up to achieve a considerably larger measurement range on muscle stiffness estimation.
In this study , BMP2 mRNA was detected by qRT-PCR and data showed that it was upregulated in NPC compared with non-cancerous nasopharynx samples.
In this study , combined TPF and SHG microscopy were used to monitor collagen remodelling in vivo after micro-ablative fractional laser resurfacing.
In this study , crotonaldehyde induced modifications of human DNA were evaluated by various physicochemical techniques.
In this study , dose requirement declined with age in a frail and wasting population as a result of weight-related pharmacokinetic factors.
In this study , DPs were isolated from human hair follicles and serially subcultured.
In this study , dry eye was associated with lower quality of life on a health-related quality-of-life instrument and the vision-specific NEI VFQ-25.
In this study , effect of bilingual proficiency on older adult's cognitive reserve was investigated.
In this study , elderly bilingual and monolingual participants performed a visuospatial interference control task during functional magnetic resonance imaging ( fMRI ) scanning.
In this study , energy-regulated molecules were evaluated in the trophocytes and fat cells of young and old workers.
In this study , extracts generated from five brown algae ( Many factors contribute to palatability.
In this study , fruits of Opuntia ficus-indica were enzymatically hydrolyzed and then fermented with two species of yeast.
In this study , gelatine was incubated for @number@ days with ribose or methylglyoxal ( MG ) .
In this study , healthy right-handed adolescents completed MRI scanning and the Controlled Oral Word Association Test ( COWAT ) .
In this study , high-resolution analytics were applied to better understand the composition of IVIg and product variations.
In this study , hot-water extract from VA ( VAE ) and its active component , rutin , were investigated to determine their antiphotoaging effects.
In this study , housing satisfaction was considered to be an indicator of quality of life.
In this study , HS and GS declined significantly after @number@ years and very dramatically after @number@ years.
In this study , IA due to ARAF isolates in HSCT recipients in Germany was investigated.
In this study , information was gathered from the websites of sixty-two U.S. dental schools in order to understand the types of geriatric courses offered.
In this study , it was discovered that spermine increases the activity of HAT and autophagy.
In this study , it was revealed that cuticle becomes more fragile and the hair surface properties deteriorate in the same age range.
In this study , many elderly people in Japan are concerned about health-care expenditures , health-care systems , and health policies.
In this study , mice with a mutation in the helicase domain of the Wrn gene were crossed to Safb1-null mice.
In this study , miRNA profiles of young , adult , and old rats were obtained to evaluate molecular changes during aging.
In this study , MSCs were isolated from the adipose tissue with enzymatic digestion.
In this study , neurologic signs and symptoms were compared pre- and posttreatment with lonafarnib.
In this study , @number@ 14- to 18-year-old subjects were photographed ( 2006-2007 ) .
In this study , @number@ elderly patients with minor to moderate knee OA combined with supra-patellar bursitis were recruited.
In this study , @number@ fetal specimens ranging from @number@ to @number@ months of age at death were dissected for anatomical and histological examinations.
In this study , @number@ HBV chronic carriers attending in @number@ the viral hepatitis ambulatory of Chapecó , were investigated.
In this study , @number@ healthy subjects underwent MRI investigation and completed a German version of the FFM personality questionnaire.
In this study , @number@ octogenarians and @number@ centenarians from the Georgia Centenarian Study completed the FOME.
In this study , @number@ % of women with hip fracture presented a time to permitted load of ≥ @number@ days.
In this study @number@ participants with AD were categorized into @number@ of @number@ cognitive phenotype classifications : typical , amnestic , language , and posterior.
In this study , @number@ raw milk cheeses were obtained from retail specialty shops , farmers ' markets , and on-line sources.
In this study , @number@ television advertisements from Hong Kong , Japan , and South Korea were analyzed to determine their representations of older people.
In this study of @number@ widowers , more than half spontaneously discussed their attitudes toward , and experiences of , these relationships.
In this study , older-onset ET was associated with MCI.
In this study , our aim was to determine how technical and physiological factors influence the quality of respiratory signals.
In this study oxidative stress , measured by increased NF-κB activity , induces LOI in both cancerous and noncancerous human prostate cells.
In this study , Participants 18-64 years old with a range of literacy competence read simple sentences as their eye movements were monitored.
In this study , participants engaged in a recognition task during a functional magnetic resonance imaging scan.
In this study , particular attention is paid on the description of microstructure changes during the aging process.
In this study , @percent@ of the modifications of the drug form could have been harmful.
In this study , phenytoin , valproic acid , carbamazepine , phenobarbital , clobazam , and clonazepam were defined as old-generation AEDs.
In this study population , an age cutoff for ICD implantation at ≤70 years yielded the highest survival for the population as a whole.
In this study , proteomic results of AD were reviewed and the AD-associated protein-protein interaction network ( PIN ) was analyzed.
In this study , quantitative analysis of inflammatory effectors mast cells and eosinophils in derma of people of different ages is performed.
In this study , spine alignment and torso depth were assessed , because both variables have been shown to affect injury risk.
In this study , the ability of 7-HC to protect human HepG2 cells against MG-induced toxicity and oxidative stress was investigated.
In this study the accumulation of AGEs and the relation between AGEs and incisional hernia were investigated.
In this study , the age-related differences in the timing aspect of lumbopelvic rhythm were investigated using the continuous relative phase method.
In this study , the age-related variations during childhood and adolescence were addressed.
In this study , the aging of culturable FIB and DNA representing genetic markers for Enterococcus spp.
In this study , the anti-aging activities of mussel oligopeptides were evaluated using H2O2-induced prematurely senescent MRC-5 fibroblasts.
In this study , the authors addressed the longitudinal nature of intraindividual variability over @number@ years.
In this study , the authors described the use of fluorescent nanosomes to detect early cartilage damage in a mouse model of osteoarthritis.
In this study , the authors evaluated the reliability of a proposed MR imaging grading system of ISL degeneration ( ISLD ) .
In this study , the authors examined how effective connectivity changed in the DMN between rest and during a memory task.
In this study , the composition of phenolic metabolites in fecal solutions was analyzed by UPLC-ESI-MS / MS in @number@ volunteers.
In this study , the data are prospectively collected using a pre-specified standardized protocol.
In this study the effect of educational intervention based on precede-proceed on quality of life in elders was examined.
In this study , the effects of the above-mentioned two characteristic phenomena of AF on blood flow and hemodynamic parameters were quantitatively investigated.
In this study , the effects of VC deficiency on skin and hair growth were investigated using SMP-30 / GNL-KO mice by RNA sequencing.
In this study , the efficacy of @number@ commercial anti-wrinkle products was evaluated using a direct non-invasive method to measure the skin surface morphology.
In this study , the expression of circRNA 100269 and its potential downstream miRNA targets were investigated.
In this study , the focus was on the mechanisms that may underlie this reduced ability.
In this study , the genetic association between collagen type II alpha @number@ ( COL2A1 ) gene and DLS was investigated.
In this study , the influence of the ageing of the spinal components on cortical shell strain was investigated.
In this study , the influence of the age of an individual who left his DNA on an object is investigated.
In this study , the inverse correlation between EGFR and ZNF216 expression was confirmed in various human cancer cell lines differently expressing EGFR.
In this study , the involvement of mammalian target of rapamycin ( mTOR ) signalling in osteoblastic differentiation of VSMCs is investigated.
In this study , the liver anatomy was quantified in both adult and pediatric populations as a function of gender and age.
In this study , the main and interactive effects of obesity and age on functional performance were assessed during intermittent exertions involving the upper extremity.
In this study , the MC and the CBT were used to assess spatial memory for navigation and for reaching , respectively.
In this study the microcirculatory characteristics and perceived symptoms in neck / shoulder region were compared among office workers with sedentary lifestyle.
In this study , the MNA-SF has a higher sensitivity and is the reference tool for routine screening in this population.
In this study , the neuroprotective effect of OXM was first examined in human neuroblastoma ( SH-SY5Y ) cells and rat primary cortical neurons.
In this study , the physiological effects of altered eIF5B expression were examined in 293T and HepG2 cells.
In this study , the prevalence , genotype frequency , and risk factors for HBV infection in @number@ HIV-infected subjects living in Piauí were determined.
In this study , the proposed system is employed for outdoor activity patterns analysis.
In this study , the rate of telomere shortening in β-thalassemia / HbE patients was compared to the rate of telomere shortening in normal individuals.
In this study , the relationship between depigmenting effect of resveratrol and SIRT1 / forkhead box O ( FOXO ) 3a activation and was investigated.
In this study , the remaining @percent@ of the spectral frequencies were analyzed to gain insight into changes that occur in meibum with age.
In this study , the sequential combination of two different laser wavelengths was evaluated to produce reliably significant clinical improvements optimizing treatment parameters.
In this study , the sleep of @number@ Black and White adults was investigated.
In this study the use of different medications at the Departments of General Medicine and Cardiology ( Tbilisi Republic Hospital ) was analyzed.
In this study , the vertebrobasilar junction showed a larger angle in the patients with DPLI than in the healthy controls.
In this study , three age-related methylation fragments were isolated and identified in blood of @number@ donors.
In this study , three pictorial versions of the Stroop task were administered to investigate inhibitory control development in early school-aged children.
In this study , two palliative care participants were monitored in a sensorized bed.
In this study , typical MD morphological phenotypes were researched in S-TAA cases and control aorta specimens using histopathological and mainly immunohistochemical analyses.
In this study we addressed the subjective benefits of activity interventions that were designed to improve cognitive fitness in old age.
In this study , we address this possible explanation empirically by reporting on data from ∼13 , 000 observers who were surveyed online.
In this study we aim at evaluating the effect of insomnia disorder on visual processing by employing a visual search paradigm.
In this study , we aimed at determining the association between dietary patterns or consumption of specific foods and LTL in Korean adults.
In this study we aimed to compare the relative bioavailability of oral doses of @number@ mg of Zn in two dosing forms.
In this study , we aimed to compare the results of these two methods and investigate age-related effects on the SVV.
In this study , we aimed to determine the effects of photoaging at histopathologic resolution by means of reflectance confocal microscopy.
In this study , we aimed to evaluate the validity of the CREDOS ischemia classification system.
In this study , we aimed to find a potent anti-glycation food material and to verify its health benefits by clinical trial.
In this study , we aimed to identify brain areas normally involved in its control.
In this study , we aimed to investigate the association of ERBB4 rs707284 and BACE1 rs490460 with the risk of SZ in an Iranian population.
In this study we aimed to objectively assess sleep and circadian rhythm in a cohort of patients with BD compared to matched controls.
In this study , we aimed to provide further evidence for these dissociations by using transcranial direct current stimulation ( tDCS ) .
In this study we aimed to systematically review studies that examined associations between childhood cognition and cardiovascular disease ( CVD ) events in adulthood.
In this study we aim to calculate the age-by-age normal values of circulating AMH.
In this study , we analyzed a large sample of local public insurance claim data to investigate medical and LTC expenditures in Japan.
In this study , we analyzed mitochondrial function in dermal fibroblasts derived from biopsies obtained from healthy young , middle-aged , and old donors.
In this study , we analyzed skin samples from @number@ NIHID and @number@ control cases immunohistochemically and electron microscopically.
In this study , we analyzed the clinical applicability of LA for elderly patients with NSCLC.
In this study , we analyzed the implication of NHEJ genes methylation in the increase of translocations with the age.
In this study , we applied hierarchical Bayesian models to explore the spatial heterogeneity of the relative risk for hypertension admissions throughout Shenzhen in @number@
In this study , we applied immunohistochemistry to follow the expression of MTH1 and the amount of 8-oxoguanine in RNA during aging.
In this study , we assessed its interobserver and different-day reproducibility.
In this study , we assessed the association between plasma HSP 70 / 27 levels and cognitive decline.
In this study , we assessed whether brachial PP is associated with the presence of WMLs in the elderly.
In this study , we assessed whether microfat transfer could improve dermal and subcutaneous tissue thickness loss associated with photoaging.
In this study , we assessed whether the neurodegenerative process of AD also affects hypothalamic hypocretin / orexin neurons.
In this study , we assess whether serum UA levels would be altered in the AD Jordanian patients compared to those of the healthy controls.
In this study , we attempted to establish the role of Rab1A in major human lung cancer subtypes.
In this study , we carried out a genome-wide array screen comparing miRNA-21 , miRNA-107 , miRNA-137 and miRNA-29b expression in meningiomas.
In this study , we characterized PHLPP protein expression and target kinases in the adult hippocampus.
In this study , we compared PTH signaling and osteoanabolic effects in hMSCs from young and old subjects.
In this study we compared the clinical outcomes of two groups of orthogeriatric patients in an orthogeriatric care ( OC ) programme.
In this study , we demonstrated positive association between uric acid and lumbar spine bone mineral density in peri- and postmenopausal Japanese women.
In this study , we demonstrated that elderly people show geographic clustering according to above-norm results of anthropometric measurements and blood chemistry.
In this study , we demonstrated that KRIBB11 accelerates the proteasomal degradation of Mcl-1 in the NSCLC cell line , A549.
In this study , we demonstrated that the expression of Ndfip1 decreased in 6-hydroxydopamine ( 6-OHDA ) -induced PD rats and 6-OHDA-treated MES23.5 dopaminergic cells.
In this study , we demonstrate that increased NF-κB activity in aged muscle fibers contributes to diminished myogenic potential of their associated satellite cells.
In this study , we demonstrate the capability of a hybrid material as a long-term filter for blood proteins.
In this study , we describe a new intronic splicing element within intron @number@ that is highly conserved across species.
In this study , we described a simple method for synthesis of Qe / CdSe / ZnS nanoparticles ( QCZ NPs ) .
In this study , we designed and executed an approach to prioritize drugs that may target multiple age related disorders.
In this study we detected the changes in the expression of lysosomal cathepsin L in cellular models of PD.
In this study , we determined that the prevalence of VCI was @percent@.
In this study , we developed cell-based biosensors to efficiently and conveniently monitor NP toxicity.
In this study , we discuss the present conditions and future problems associated with the perioperative management of such patients.
In this study , we employed laser ablation-inductively coupled plasma-mass spectrometry on PFA-fixed brain sections obtained from two adult common marmosets.
In this study , we established an immortalized PDLSC cell line by the introduction of Bmi1 ( PDLSC-Bmi1 ) .
In this study , we establish the RIs for serum HE4 , CA125 and ROMA in healthy Chinese female with ECLIA.
In this study , we evaluated a hypothesis that this principle does not apply to rapid reach-to-grasp movements evoked by sudden unexpected balance perturbations.
In this study , we evaluated FoR reliance for self-motion perception with respect to the ground surface.
In this study , we evaluated in mice bearing medulloblastoma xenografts the effect of age on tumor progression and tumor therapy.
In this study , we evaluated the age-related changes in muscle strength and spinal kyphosis in @number@ males and @number@ females ≥50 years of age.
In this study , we evaluated the application of the 755nm picosecond alexandrite laser with a diffractive lens array for facial photoaging in Chinese.
In this study , we evaluated the effect of precueing characteristics of an impending perturbation to upright stance on reactive responses of distal leg muscles.
In this study , we evaluated the neuroprotective effects of DJS on dopaminergic ( DA ) neurons damaged by 6-hydroxydopamine ( 6-OHDA ) .
In this study , we evaluated the subsequent symptoms of Japanese hypogonadal patients who had received ART , within several years previously by mail-in survey.
In this study we evaluate the influence of erythrocyte aging on the fibrinogen binding.
In this study we evaluate the kinetics of γδ T cells after vaccination with the trivalent 2011 / 2012 northern hemisphere seasonal influenza vaccine.
In this study , we examined how these cultural differences in context processing affect how people interpret facial emotions.
In this study , we examined in detail the VO ( 2max ) differences found among mitochondrial haplogroups.
In this study , we examined over @number@ years the effect of change in FOF on functional decline in community dwelling elderly.
In this study , we examined personality traits of older adults and their emotional experiences associated with engaging in specific leisure activities.
In this study , we examined the age-related differences in the organization of an emotionally goal-directed locomotion task.
In this study , we examined the association between visual spatial attention to task-irrelevant stimuli and falls risk in community-dwelling older adults.
In this study , we examined the association between volume of hippocampal subfields and age differences in virtual spatial navigation.
In this study , we examined the effectiveness of community-based fall assessment compared with hospital-based assessment.
In this study , we examined the effects of xyloketal derivatives on extending lifespan and healthspan of Caenorhabditis elegans.
In this study , we examined the expression of cyclin K in various murine and human tissues.
In this study we examined the physical and functional interaction between WRN and RPA specifically in relation to replication fork blockage.
In this study , we examined the relationship between autophagy and skin aging.
In this study we examined the role of Cav-1 in mediating DISC1 expression in neurons in vitro and the hippocampus in vivo.
In this study , we examined the role of the Wnt signaling inhibitor secreted frizzled-related protein-1 ( sFRP-1 ) in aged wild-type and sFRP-1-deficient mice.
In this study , we examined the toxicity of SDM in cell culture and looked at protection using L-carnosine.
In this study , we examined whether polymorphisms of the IL-1β gene also influence cognitive functions in elderly females.
In this study we examined whether the beneficial effects of HUCB injection were attributable to one of these cell types.
In this study , we examined whether the presence and degree of objective cognitive impairment varied according to the use of published versus local norms.
In this study , we examined whether this interaction is altered by advancing age.
In this study , we examine the association between melatonin levels and sleep among older men.
In this study , we explored host mucosal glycans as a potential age-specific factor for attachment of P [ @number@ ] RVs.
In this study , we explored regional gray matter ( GM ) volumetric associations of the five-factor model of personality.
In this study , we explored some skin texture parameters for evaluating skin aging using digital image processing.
In this study , we explored the anti-oxidative potential of oligomeric proanthocyanidins ( OPCs ) , natural flavonoid compounds.
In this study , we explored the challenges of intergenerational families in caring for frail older people in Taiwan.
In this study we explored the experience of what sexuality implied and meant to older widows using the descriptive phenomenological approach.
In this study , we explore the potential connection ( s ) between H3K9me3 loss and the impaired DDR in HGPS.
In this study , we explore the role of CHIP in regulating p53 in senescence.
In this study , we first confirmed the activity of Wnt signalling in mouse , dog and human testes.
In this study , we first demonstrate that NSC cultures ( NS cells ) exposed to BMP4 acquire cellular and transcriptional characteristics of quiescent cells.
In this study , we focused on patients simultaneously diagnosed with obesity and type @number@ diabetes ( OB / T2D ) .
In this study , we focused on the Klotho gene , which is an anti-aging gene known to be a potential tumor suppressor.
In this study , we focused on the Klotho gene , which is an anti-aging gene known to be a potential tumor suppressor.
In this study , we focused on the unclarified issue of whether the neurotoxicity of Aβ oligomers is a reversible process.
In this study , we found a significant correlation between NRF2 and IL-11 status in breast cancer patients.
In this study , we generated a transgenic mouse that overexpresses AIMP3 and characterized the associated phenotype in vivo and in vitro.
In this study , we have analyzed the impact of HPL-donor age on culture expansion.
In this study , we have characterized the biochemical , biological and structural properties of FK228 analogs as PI3K inhibitors.
In this study , we have demonstrated the role of H. pylori in the activation of EGFR via TAK1-mediated phosphorylation of p38.
In this study , we have evaluated CDKN2 locus transcripts as alternative BoAs in C-HC.
In this study , we have examined the lactate and the progerin production of human normal cutaneous cells issued from subjects of different ages.
In this study , we have explored the consequences of AChE-PS1 interactions.
In this study , we have focused on N170 as a visibility-related signal for quantitative evaluation of cataract.
In this study , we have found that 14-3-3ζ is copurified and co-immunoprecipitates with tau from NFTs of AD brain extract.
In this study , we have generated a refined pharmacophore with an additional twelve quercetin analogs.
In this study we have investigated the impact of aging on DNA methylation in mature human sperm.
In this study we have localized collagen XVII specifically to neuronal lipofuscin granules using electron microscopy in autopsy samples from the human brainstem.
In this study , we have newly developed 15d-PGJ₂-immobilized beads by conjugating 15d-PGJ₂ to the surface of these nanobeads.
In this study , we hypothesized that decreasing levels of nutrients would be associated with decreased hemagglutination inhibition ( HAI ) responses to influenza vaccination.
In this study , we hypothesized that Fyn expression in the brain is influenced by AD status and genetic content.
In this study , we identified PlGF-1 and PlGF-2 as the major PlGF isoforms in RA-FLSs.
In this study , we identified the eukaryotic protein CD98hc as a partner for Brucella T4SS subunit VirB2.
In this study , we identified the glycine-rich domain ( GRD ) of hnRNP proteins as a unifying feature in splice site repression.
In this study , we identify an unexpected non-cell autonomous role of epidermal polarity proteins , molecular determinants of cytoarchitecture , in malignant melanoma.
In this study , we introduce the results and perceptions of previous studies investigating these aberrations.
In this study , we investigate aging men's thoughts about , and beliefs , in a ' male climacteric'.
In this study , we investigated epigenetic differences in BD participants with and without a history of SB.
In this study , we investigated how DATS induces apoptosis in T24 human bladder cancer cells in vitro.
In this study , we investigated its role in dementia using large clinical cohorts.
In this study , we investigated potential mechanisms for epigenetic regulation of Nox4.
In this study we investigated RNA-editing changes during human brain development and maturation , as well as evolutionary conservation of RNA-editing patterns across primates.
In this study , we investigated SIRT1 phosphorylation and protein degradation in response to JNK1 activation in obese mice.
In this study , we investigated sleep alterations , the factors involved , and the role of cortisol in sleep-related problems in institutionalised individuals.
In this study , we investigated the acetylation of K2 in γD-crystallin in aging and cataractous human lenses.
In this study , we investigated the anticancer effects of GSK-3β inhibitors on cancer cell lines and observed centrosome dysregulation which resulted in abnormal mitosis.
In this study , we investigated the association of midlife quality of close relationships with subsequent cognitive decline.
In this study , we investigated the association of nutritional status and habitual dietary intake with skin conditions in community-dwelling older people.
In this study , we investigated the consequences and measurability of the reduced crosslinking.
In this study , we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence.
In this study , we investigated the early consequences of inactivating Rb in the context of cellular reprogramming.
In this study , we investigated the effect of age on the genetic component of bone loss in a large twin-based longitudinal study.
In this study , we investigated the effect of ASC on photo-aged human dermal fibroblasts ( HDF ) based on paracrine function.
In this study , we investigated the effects of CA on cell viability and apoptosis in HCT116 human colon cancer cells.
In this study , we investigated the effects of NBP in rotenone models for Parkinson's diseases.
In this study , we investigated the emotion recognition profile of MCI subgroups.
In this study , we investigated the expression of Rab1B and MMP9 in CRC by qRT-PCR , immunoblot and immunohistochemistry and analyzed the clinical significance.
In this study , we investigated the generalizing effects of an adaptive WM intervention on nontrained measures of WM and visuospatial skills.
In this study we investigated the impact of lenticular opacities on BY- and standard pattern reversal VEPs by examining patients before and after cataract surgery.
In this study , we investigated the mechanisms of action of resveratrol on steroidogenesis in human adrenal H295R cells.
In this study we investigated the possible influence of individual surgeons on clinical voiding parameters and post-operative sexual function after TURP.
In this study , we investigated the protective effect of @percent@ ethanol extracts of Eucalyptus globulus on UV-induced photoaging in vitro and in vivo.
In this study we investigated the relationship between educational level and dementia related deaths for cohorts of people all born during 1915-39.
In this study , we investigated the relationships between mechanical property and aging biomarkers in passaged human dermal fibroblasts ( HDFs ) .
In this study , we investigated the role of FoxO3a , which is a key factor in oxidative stress-related cellular responses in melanogenesis.
In this study , we investigated the role of FSHβ in BMP9-induced osteogenesis in MEFs.
In this study , we investigated these effects in young adult subjects who either underwent WMT or received no intervention for @number@ weeks.
In this study , we investigated the spectrum of NOTCH3 mutations in Korean patients with CADASIL.
In this study , we investigated whether ADSC could be used as an anti-ageing therapy , especially by dermal collagen synthesis and angiogenesis.
In this study , we investigated whether alpha-synuclein pathology is altered in the absence of PINK1 in cell culture and in vivo.
In this study , we investigated whether and why age affects the diagnostic efficiency of HbA1c for diabetes in a community-based Chinese population.
In this study , we investigated whether declined neurogenic differentiation capacity is associated with an altered expression of Wnt signaling-related proteins in vitro.
In this study , we investigated whether RBM24 is capable of regulating p63 expression.
In this study , we investigated whether the distribution of the cement in the vertebral body is related to the occurrence of recompression after surgery.
In this study , we investigated whether this functional polymorphism mediates the brain networks in patients with Alzheimer's disease.
In this study , we investigate the biological functions of a Drosophila homolog of human MRP4 , dMRP4.
In this study , we investigate the validity of a summary measure of weight history.
In this study , we investigate the way in which technological support can assist in the organisation , structuring and remembering of daily activities.
In this study we looked for evidence and for the targets of plasma protein carbonylation in patients on hemodialysis.
In this study , we mainly investigated various components of BER in mitochondrial extracts of AD and matched control postmortem brain samples.
In this study , we manipulated stress levels in 7-8- and 12-14-year-olds and then exposed them to negative , neutral , and positive word lists.
In this study , we measured the effects of tDCS on associative memory performance in healthy adults , using both recognition and recall tests.
In this study we measured the local and systemic inflammatory response after influenza vaccination or infection in neonatal , young adult and aged mice.
In this study , we measured volume of brain regions that vary in their vulnerability to aging and estimated local iron content via T2 relaxometry.
In this study , we observed that the cell number and GAG ( glycosaminoglycan ) formation dramatically decreased with aging.
In this study , we performed genome-wide gene- and pathway-based analyses of depressive symptom burden.
In this study , we present a high-sensitivity long-run real-time PCR technique for DNA-damage quantification ( LORD-Q ) in both the mitochondrial and nuclear genome.
In this study , we present a novel method for the production and purification of an antagonist to human LIF-R ( hLA ) .
In this study , we presented the detailed clinical features of @number@ GSS pedigrees with PRNP p.P102L mutation.
In this study we present evidence based on data from Dutch employers and employees.
In this study , we present evidence that although the truncated LDLR isoforms are translated in vitro , they represent < @percent@ of CSF proteins.
In this study we present evidence that the pathways left by receding blood vessels remain as lamellar cross bridges.
In this study , we propose a mobile vital sign measurement and data collection system for chronic disease management..
In this study , we propose a new hybrid mobile-cloud computational solution to enable more effective personalized medical monitoring.
In this study , we proposed a theoretical definition of the PLT , based on a new method of fall event division.
In this study , we propose that neuroplasticity-based training may facilitate coherent interaction of distant brain regions and consequently enhance cognitive performance in elderly people.
In this study , we provide evidence that the Akt signaling pathway plays an important role in telomere protection.
In this study , we refine the definition of cognitive frailty based on existing reports about frailty and the latest progress in cognition research.
In this study we related these three dietary patterns to incident Alzheimer's disease ( AD ) .
In this study we report both the genotoxicity and immunogenicity of AGEs formed by MG-Lys-Cu ( 2 + ) system.
In this study , we report clinical and pathological features of a series of @number@ UCOGCs , including the whole exome sequencing of eight UCOGCs.
In this study , we report normal reference ranges for Doppler parameters obtained in a large group of healthy volunteers.
In this study , we report our findings regarding a new confrontational naming test , the Memory for Names test.
In this study , we report that age-related changes also occur in the human hematopoietic stem cell compartment.
In this study , we report the role of ZIP4 in human epidermis.
In this study , we retrospectively reviewed the efficacy of this system for lung transplantation opportunities and outcomes.
In this study , we review experimental data on the GABAergic system in the pathobiology of AD and discuss relevant therapeutic implications.
In this study , we set out to determine the prevalence and impact of shoulder symptoms and dysfunction in an older adult veteran population.
In this study , we showed that chronic supplementation of taurine to aged mice significantly ameliorated the age-dependent decline in spatial memory acquisition and retention.
In this study , we showed that xanthohumol ( XN ) induces paraptosis of leukemia cells.
In this study , we showed the safety and good adherence of hybrid training for lower extremities in elderly people.
In this study , we show that DMN functional connectivity ( FC ) during rest is altered with increasing levels of PIB uptake in NC.
In this study , we show that SSH1 binds to gelsolin via actin filaments in the cytosolic fraction.
In this study , we sought to determine the impact of aging and AMD on expression of the endothelial cell glycoprotein CD34.
In this study , we sought to determine the molecular and behavioral consequences of kalirin reduction in APPswe / PSEN1dE9 mice.
In this study we sought to evaluate biochemical differences in human donor eyes between very thin and thick choroids.
In this study , we sought to evaluate prestroke measures of frailty and related factors as markers of vulnerability to poor outcomes after ischemic stroke.
In this study , we sought to examine whether LA is a predictor of outcome after spontaneous ICH.
In this study , we sought to replicate these results in an older population.
In this study , we sought to verify this finding in older men.
In this study , we studied @number@ cases of adult-onset NIID and described their clinical and pathological features.
In this study , we systematically reviewed the available literature on health economic evaluations of switching from TIV to QIV.
In this study , we tested @number@ schizophrenia patients and @number@ healthy volunteers in China.
In this study , we tested whether oocyte's reprogramming ability decreases with aging.
In this study , we tested whether repeated doses of hUCB MNCs would be more beneficial than a single dose of cells.
In this study , we therefore investigate age-related changes induced by processing of vestibular sensory stimulation.
In this study , we therefore projected major cancer incidences based on the earlier results leaving estimated values for the age and cohort effects.
In this study we trained older adults to judge the temporal order of visual and auditory stimuli.
In this study , we tried to identify factors that influence HRQOL in elderly patients hospitalized with chronic heart failure in Serbia.
In this study , we uncovered the way natural selection has completed this task during mammalian evolution.
In this study , we used a mouse TD model to assess the involvement of PKR in neuronal death and the molecular mechanisms of AD.
In this study , we used artificial neural networks to model the emergence and evolution of allocation decisions related to reproduction in simulated populations.
In this study , we used EA.hy926 endothelial-like cells to explore the anti-inflammatory activity of andrographolide.
In this study , we used H9c2 and H9c2-GSN stable clones in an attempt to understand the mechanisms of GSN overexpression in cardiomyocytes.
In this study , we used human fetal pancreatic progenitor cells to identify the forkhead protein FoxO1 as the key regulator for cell differentiation.
In this study , we used K19-Wnt1 / C2mE ( Gan ) mice and examined the role of Vash2 in spontaneous gastric cancer formation.
In this study , we used the human placenta-derived MSCs ( PDMSC ) to investigate the effectiveness of HA in maintaining the PDMSC.
In this study , we use the behavioral economic approach of revealed preferences to quantify subjective effort.
In this study we utilized clinical data , retinal imaging and transcriptomics approaches to comprehensively interrogate non-infectious HIV retinopathy.
In this study , we validate this whole-brain health assessment approach using several clinical MRI examinations.
In this study , young and elderly participants were compared on WM tasks in which the difference in processing speed was controlled by CL manipulations.
In this study , younger and older adults studied word pairs before choosing half of the word pairs for restudy.
In this study , younger and older subjects performed a static postural maintenance task with two types of directional force perturbations.
In this subgroup , the survival curves of vitamin E and no-vitamin E participants diverged at @number@ years.
In this subgroup , use of this medication was associated with the same factors as in the overall study population.
In this symposium , the utility of existing brain imaging technologies to assess the effects of nutritional intervention in humans is described.
In this system , DDE significantly increased lipid accumulation by @percent@ and @percent@ and was associated with an induction of PPARγ2 and adiponectin mRNA expression.
In this system NHEJ efficiency can be compared across tissues of the same mouse and in mice of different age.
In this task there is little test-decay when different objects are used as targets and baseline valance for objects is controlled.
In this trial , we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS.
In this trial , we determined the efficacy and safety of minoxidil @percent@ lotion for eyebrow enhancement compared with placebo.
In this view , cancer is development gone awry.
In this way , spindles can serve as a biological marker for structural brain changes and the related memory deficits in older adults.
In this way , the encoding and retrieval deficit can be reduced in these people.
In this way , the ultrasound scan operator can rely on a simple reference scheme.
In this way , transnational care-motivated mobility affects future security based on kin reciprocity.
In this work RSV-loaded solid lipid nanoparticles ( SLN ) and nanostructured lipid carriers ( NLC ) were prepared using a homogenization / sonication technique.
In this work , the mechanical properties of human coronary arteries have been characterized.
In this work we advocate the use of simulation as a tool to assist the understanding of immune aging phenomena.
In this work we analyse NK cell subsets in the elderly in relation with markers of inflammation and health status.
In this work , we describe the medicinal chemistry optimization of the hit molecule following a quantitative high-throughput screen of > 355 , 000 compounds.
In this work , we discuss this and other aspects of temporal scaling.
In this work we explore health status and medicine consumption among a sample of academic employees over @number@ years of age at a Mexican university.
In this work , we identified the cytoskeleton-associated α-N / E-catenins as novel nesprin-2-binding partners.
In this work , we investigated the participation of reactive oxygen species ( ROS ) in the establishment of this response.
In this work , we investigated the response to different emotional stimuli and the effect of age on the neuronal activation.
In this work , we perform a systematic analysis of the gerontome across species , including human aging-related genes.
In this work we present a supervised regulatory network inference method with aim to identify potential target genes ( mRNAs ) of microRNAs.
In this work , we propose a novel mathematical model of the molecular system that controls the aggregation and deformability of the erythrocyte.
In this work , we provide evidence that DBC1 regulates glucose metabolism and the expression of PEPCK.
In this work we test whether these Lipocalins also protect against poly-Q-triggered deterioration of protein quality control systems.
In those > 65 years of age , the fasting glucose group was no longer a significant predictor of AD.
In those ≥ @number@ years the indication was more often suspected ileus ( @percent@ Vs @percent@ , P = 0.004 ) .
In those participants using insulin , compared with participants without diabetes , the HR was @number@ ( @number@.78-5.07 ) .
In those people , S. sanguinis produces more H2O2ex vivo.
In those people who were classified as having abnormal cortical thickness , degree and topographic specificity of neurodegenerative abnormalities were similar to patients with AD.
In those subjects with both vascular and amyloid pathologies , the effect of both pathologies on cognition was additive and not synergistic.
In those with and without delirium , cognitive decline and dementia will be assessed at one year follow-up.
In those with below-average IQ , however , only around @percent@ FA variability in the same regions was attributable to genetic factors.
In those with incomplete registration no increase in body weight was found.
In those without children , aging was associated with greater upper body girths and reduced lower body girths , in both sexes.
In those with poor spatial acuity , cortical responses contained little information with which to distinguish peripheral locations.
In THP-1 monocytes , γTP inhibits cell proliferation and reduces CD36 scavenger receptor expression more potently than αTP.
In three experiments , we examined identity memory , location memory , and their combination in a visuospatial working memory ( VSWM ) paradigm.
In three experiments , we examined the effects of age and spatial processing on implicit sequence learning.
In three experiments , we used event-related brain potentials ( ERPs ) to examine influences of fluency on source memory for famous names.
In three functional magnetic resonance imaging ( MRI ) experiments we demonstrate that people make less head movements under task than resting-state conditions.
In three review rounds , the QI set was adapted and judged on face and content validity.
In three separate experiments , women and men encoded female and male faces for later recognition in full attention and divided attention conditions.
In Tibetans contacting animals or not was @percent@ and @percent@ respectively , and breeding dogs or not was @percent@ and @percent@ , respectively.
In tight control , the potency of antidiabetic treatment should be reduced.
Intimal area and cellularity showed no statistically significant increases with age ; in contrast , total collagen content showed a significant decrease with advancing age.
Intimal media thickness ( IMT ) and presence of arterial calcifications are well-known risk factors for cardiovascular death in hemodialysis patients.
Intima-media thickness was not related to ADM single nucleotide polymorphisms or expression.
In time , for species with evident aging , some reactions lose their specificity , which affects cell division and differentiation.
( Int J Colorectal Dis @time@ @number@ @number@ ) reported that diverticula and cancer are rarely coincident in the colon , despite aging.
Int J Occup Med Environ Health @number@ ; 29 ( @number@ ) : 903-914.
In today's society , ageing is a phenomenon which is as natural as it is complex.
In today's youth driven society , our observations may serve as a powerful impetus for some to quit smoking.
Into late life , the pattern reverses but shows clear differences from early life.
In total from the 4th till the 9th decennium , the capillary bed in the papillary dermis was diminished by @percent@.
In total , half the TCSs had at least one of three sex hormone levels outside the reference range at SII.
In totality , the results highlight the importance of controlling for g when investigating associations between specific cognitive abilities and neuropsychology variables.
In total , @number@ CRC cases and @number@ controls from the screening setting and @number@ CRC cases from the clinical setting were measured.
In total , @number@ different surface conditioning methods , mainly combinations of air-abrasion protocols and adhesive promoters ( primers or silanes ) , were investigated.
In total , @number@ first impressions were recorded , totaling @number@ individual assessments of first impression.
In total , @number@ individuals were recruited from @number@ to @number@ and followed until @number@
In total , @number@ kinematic variables were extracted to train the classification algorithm and test the generalized performance.
In total @number@ known miRNAs , @number@ miRNA candidates and @number@ targets were identified.
In total , @number@ miRNAs , including one putatively novel miRNA , were identified.
In total , @number@ older non-demented diabetic individuals with an average age of @number@ ± @number@ were recruited.
In total , @number@ older people ( @number@ men and @number@ women ) completed the questionnaire.
In total , @number@ participants from two cities were interviewed.
In total @number@ participants were interviewed and the data analysed thematically using Braun and Clarke's ( @number@ ) approach.
In total , @number@ patient blood spot samples and @number@ control samples were analysed.
In total , @number@ patients diagnosed with Alzheimer's disease were enrolled at baseline.
In total , @number@ patients meeting the age criterion were included.
In total , @number@ patients underwent radical prostatectomy.
In total , @number@ patients were diagnosed with new dementia.
In total , @number@ patients were included in the study , and @number@ ( @percent@ ) of them received a diagnosis of diabetes.
In total , @number@ patients with fALS from @number@ kindreds , @number@ patients with sALS , and @number@ control subjects were included.
In total , @number@ people aged ≥65 years participated.
In total , @number@ subjects comprising @number@ PD patients and @number@ control subjects were genotyped.
In total , @number@ subjects , from an overall population of @number@ were included in this study.
In total , @number@ Turkish respondents returned filled-in questionnaires ( @percent@ response rate ; out of @number@ ) .
In total , @number@ workers of a Dutch division of a multinational organization participated.
In total , our new findings may help to deepen our understanding of the molecular mechanisms involved in AD-related circadian alterations.
In total , @percent@ fish farm household members were infected with FZT.
In total , @percent@ ( N = @number@ ) of the intervention group participated in more than @percent@ the supervised group sessions.
In total , @percent@ ( n = @number@ ) presented with vitamin D deficiency , @percent@ of whom were women.
In total , @percent@ of participants in the active arm and @percent@ in the placebo arm completed @number@ months.
In total , @percent@ of the eyes in group B showed a positive variation of > 10%.
In total , @percent@ patients were treated at designated regional cancer hospitals ( prefectural or local ) .
In total , @percent@ reported living in a shelter for the last @number@ days , while @percent@ were unsheltered.
In total , @percent@ were white , @percent@ were women and their mean age was @number@ years at enrollment.
In total , there were @number@ rounds of interactivity between the participants to arrive at the final version of the construct.
In total , these data indicate that ROS are a key contributor to CAA formation , CAA-induced vessel dysfunction , and CAA-related microhemorrhage.
In total , we demonstrate that aging directly promotes HSC fitness decline and somatic evolution via non-cell-autonomous mechanisms.
Into the early 20th century , erotic age orientation remained bound up with the classification and emancipation of what here was demarcated as Urningsliebe.
Into this breach has developed an innovative and exciting movement in gerontology to provide a deeper and more comprehensive insight into the meaning of ageing.
Intra-abdominal fat distribution , including subcutaneous , preperitoneal and visceral fat thicknesses , was assessed by ultrasonography.
Intra-abdominal fat distributions obtained by ultrasonography may provide clinicians with valuable information needed to determine cardiovascular disease risk factors in obese adolescents.
Intra- and interindividual variability were similar to the human methodology.
Intra- and inter-rater reliability scores were consistent for gain values ; however , poor to fair inter-rater reliability scores were observed for velocity values.
Intra-articular corticosteroids and hyaluronic acid have also shown modest symptomatic efficacy with generally good tolerability.
Intracardiac oscillatory structures can also be seen as \ "tiger stripes \ " on spectral pulsed Doppler echocardiographic recordings.
Intracellular ATP level of a single cell was estimated to be over @number@ mM.
Intracellular Ca²⁺ was measured in isolated urothelial cells with fura-2.
Intracellular delivery and mitochondrial target ability issues pose additional hurdles.
Intracellular events in neurons , which lead to memory loss in MHE by elevated DA , however , remain elusive.
Intracellular inclusions seen by the pathologist may have variable significance.
Intracellular level of ROS was measured with DCFH-DA staining by flow cytometry analysis.
Intracellular miRNAs could modulate mRNA activity through target-specific binding and play a crucial role in intercellular communications.
Intracellular pathways implicating nutrient sensors , such as SIRTs and mTOR complexes , impinge on cellular and epigenetic mechanisms that control the aging process.
Intracellular stress induces changes in the endoplasmic reticulum yielding misfolded proteins that contribute to the underlying pathophysiological changes.
Intracellular Zn²⁺ concentration mainly increases through calcium-permeable channels and serves as Zn²⁺ signal as well as extracellular Zn²⁺ concentration.
Intracerebral administration , compared to peripheral route , requires an invasive procedure to directly implant stem cells into injured brain.
Intracerebral hemorrhage occurred in @number@ of @number@ ( @percent@ ) patients , with no symptomatic hemorrhage.
Intracerebral pressure recordings demonstrated that shock waves traversed the mouse brain with minimal change and without thoracic contributions.
Intracerebroventricular administration of OXM significantly reduced cerebral infarct size and improved locomotor activities in MCAo stroke rats.
Intraclass coefficients ranged from @number@ to @number@
Intraclass correlation coefficient ( ICC ) was calculated for total MAT scores from @number@ patient meals assessed by two raters.
Intraclass correlation coefficients ( ICC ) and trend estimates were summarized by genomic location and probe type.
Intraclass correlation coefficients ( ICCs ) and coefficients of variation ( CoVs ) were calculated for the parameters extracted from the CMAP scan.
Intraclass correlation coefficients ( ICCs ) indicated modest-to-excellent test-retest reliability ( ICC = 0.64-0.85 ) .
Intraclass correlation coefficients ( ICC ) were calculated to determine test-retest reliability of all instrumented standing balance and instrumented TUG measures.
Intraclass correlation coefficients ( ICC ) were used to determine test-retest reliability.
Intracortical ( osteonal ) bone remodeling is the principle mechanism for maintaining cortical bone quality.
Intracortical pore distribution analysis may ultimately provide insight into both mechanisms of pore network expansion and biomechanical consequences of pore distribution.
Intracranial volume ( ICV ) normalization of regional brain volumes ( v ) is common practice in volumetric studies of the aging brain.
Intracranial volume reflects the maximally attained brain size during development , and remains stable with loss of tissue in late life.
Intractable secondary spontaneous pneumothorax ( SSP ) is occasionally lethal.
Intracycle variability of InhB and AMH were assessed after aligning to the LH surge.
Intradermal electroporation ( EP ) vaccination resulted in transfection of different skin layers , as well as mononuclear cells.
Intradermal PRGF infiltration appears to be an effective treatment for the photodamaged skin.
In traditional medicine , a large number of medicinal plants have been used to treat the symptoms of these neurodegenerative diseases.
Intra-erythrocyte Mg levels were not significantly correlated with many laboratory or clinical parameters.
Intra-expert and inter-expert agreements were calculated as F1-scores , Cohen's kappa ( κ ) , and intra-class correlation coefficient ( ICC ) .
Intrafamilial associations of cardiometabolic risk factors are rarely studied and the few existing results are inconsistent.
Intraindividual variability ( IIV ) in reaction time has been related to cognitive decline , but questions remain about the nature of this relationship.
Intraindividual variability increases with age for both Whites and Blacks and such increase is greater for Blacks.
Intraindividual variations in optical coherence tomography results were small in each group.
Intralacunar hypermineralization accompanied by a decrease in total osteocyte lacunar density may contribute to failure or delayed bone repair in aging bone.
Intramembrane cleavage of Smac by PARL generates an amino-terminal IAP-binding motif , which is required for its apoptotic activity.
Intramyocellular lipid content was decreased after EET concomitantly with total body fat.
Intranasal administration of PRGF-Endoret to APP / PS1 mice resulted in an important decrease in brain Aβ deposition and tau phosphorylation.
Intranasal insulin has also been shown to improve memory and cognitive abilities in MCI and AD patients.
Intraneuronal amyloid-β ( iAβ ) accumulation has been demonstrated in Alzheimer disease ( AD ) .
In transgenic mouse models of Alzheimer's disease-like pathology , lesioning the locus coeruleus exacerbates β-amyloid ( Aβ ) pathology , neuroinflammation and memory deficits.
In translational terms , autophagy is undoubtedly an attractive target for developing new renoprotective treatments and identifying markers of kidney injury.
In transplantation , professionals are daily faced with risk assessment of suitable donor offers , whether to accept a liver graft for a specific recipient.
Intraocular center surround contrast suppression was increased in older adults compared to younger adults ; however , interocular suppression was similar in both groups.
Intraocular pressure-induced axonal injury at the optic nerve head leads to apoptosis.
Intraocular pressure ( IOP ) was measured with the Dynamic Contour tonometer and central corneal thickness ( CCT ) was also evaluated.
Intra-oocyte PI3K / mTOR pathways have been indicated to play a central role on the activation of primordial follicles.
Intraoperative complications were absent.
Intraoperative difficulties were compared with normal laparoscopic approach.
Intraoperative drugs and the postoperative sulfentanil requirement of the PNBs group were lower ( all P < 0.001 ) .
Intraoperative fluoroscopy ( IF ) was always performed intraoperatively.
Intraoperative MRI- and fluorescence-guided surgery assist in achieving this goal of supra-maximum resection and have been the subject of an increasing number of reports.
Intraoperative red blood cell transfusion of @number@ U or more was predictive of higher morbidity in the elderly.
Intra-oral examinations were performed by one of six dentists calibrated to W.H.O. standards.
Intra-orbital structures demonstrated specific qMRI measurements and aging patterns , which were different from extra-orbital structures.
Intraparenchymal distribution pattern correlated with younger age , lobular activity , and early fibrosis stage.
Intrapatient randomization determined split-area treatment with a blue or red light source.
Intrapatients group comparison involved type of BD and comorbidities.
Intrarater agreements after repeat testing were @number@ and @number@ respectively.
Intra-rater reliability was determined using Kappa ( K ) statistics and inter-rater reliability was determined using ICC.
Intra / RR and inter / RR were highly significant.
Intrauterine infection occasionally causes microcephaly , sensorineural hearing loss and mental retardation.
Intravascular oxidative generation and collagen deposition were assessed.
Intravenous administration of Ad-SMP30-HA in mice results in the expression of all the three forms of SMP30 in the liver and diaphragm.
Intravenous administration of haloperidol in the critically ill and profoundly agitated elderly warrants particular comment.
Intravenous allogeneic MSC infusion has proven to be safe in a phase-I trial in patients with acute MI.
Intravenous immunoglobulin ( IVIg ) is a complex mixture drug comprising diverse immunoglobulins and non-IgG proteins purified from the plasma of thousands of healthy donors.
Intravenous infusion in AKO rats of human amylin , or combined human amylin and apolipoprotein E4 , showed that amylin binds to plasma apolipoproteins.
Intravenous therapy with either micafungin or L-AmB given as either intermittent or continuous therapy was recommended for chronic pulmonary aspergillosis due to a pan-azole-resistant Aspergillus.
Intravenous-to-oral azithromycin therapy demonstrated excellent clinical and bacteriological effects on moderate-to-severe pneumococcal pneumonia despite a high MIC and resistance gene development.
Intravital and post-mortem degradation of elastin may have a moderate effect on the AAR values.
In triadic interaction , infants interacted with the adult stranger as she coordinated gaze between the infant and object.
Intrigued by these findings , we investigated whether oAβ and oTau share a common mechanism when they impair memory and LTP in mice.
Intriguingly , ALA blocked the Pi-induced VSMC apoptosis and calcification by recovery of mitochondrial function and intracellular redox status.
Intriguingly , apolipoprotein ε4 carriers had significantly higher string vessel counts relative to non-ε4 carriers.
Intriguingly , a portion of the age-related changes in sperm DNA methylation are located at genes previously associated with schizophrenia and bipolar disorder.
Intriguingly , C. elegans and P. pacificus exhibit similar , but not identical , responses to nickel exposure.
Intriguingly , conditional Aβ₁₋₄₂ expression limited to young animals exacerbates the aging process to a greater extent than Aβ₁₋₄₂ expression in old animals.
Intriguingly , high-fat fed S467A mice displayed increased locomotor activity and energy expenditure , which coincided with a reduced body weight gain.
Intriguingly , Kif14 knockout mice also showed primary microcephaly.
Intriguingly , many of these effects seem to be controlled by only a subset of cells implying a systemic regulation in a cell non-autonomous manner.
Intriguingly , overexpression of p16 ( Ink4a ) has also been described in several tumors.
Intriguingly , recent studies demonstrated similar brain function alterations between APOE ϵ2 and ϵ4 alleles , despite their opposite susceptibilities to AD.
Intriguingly , resveratrol treatment of cells growing in nutrient-rich conditions induces autophagy , while acute resveratrol treatment of cells in a serum-deprived state inhibits autophagy.
Intriguingly , several maneuvers that increase the lifespan of model organisms in the laboratory , like caloric restriction , do so in an autophagy-dependent manner.
Intriguingly significant Group Age interactions were observed for both copper and iron , suggesting gradual age-associated decline of these metals in healthy non-cognitively impaired individuals.
Intriguingly , the current trend is to consider regeneration as a prerogative of the youngest organism.
Intriguingly , the intervention-induced changes in the coherence of local spontaneous activity correlated with the improvements in individual cognitive performance.
Intriguingly , the potency of the individual nucleotide as energy source for hSuv3 unwinding differed depending on the included divalent cation and nucleotide concentration.
Intriguingly , the remaining @number@ mutations clustered , had higher surface exposure , and did not affect stability.
Intriguingly , the renal cell carcinoma disease gene product von-Hippel-Lindau protein was shown to regulate lifespan in the nematode.
Intriguingly though , bolus WP offers no trophic advantage over LEAA.
Intriguingly , Tie2 reactivation using a Tie2 agonistic antibody rescued the POAG phenotype in Angpt1 / Angpt2-deficient mice and rejuvenated the SC in aged mice.
Intriguingly , when novel scenes were shown , only the older adults showed an increased tendency to identify these as familiar scenes.
Intrinsic ageing is highly related to chronological age.
Intrinsic ageing of the skin is a subtle process resulting in some degree of skin laxity.
Intrinsic and circadian fluctuations , occurring independently of presynaptic stimulation , demonstrate the native instability of spines.
Intrinsic and extrinsic pathways that might be common to bone marrow hematopoietic stem cells and memory T lymphocytes are discussed and related to self-renewal functions.
Intrinsic and extrinsic stressors are believed to cause electrostructural alterations in the atrial tissue leading to profibrillatory state.
Intrinsic factors are patient-related and extrinsic factors are environment-related.
Intrinsic factors induce EC and SMC transformation resulting in cellular senescence.
Intrinsic functional connectivity MRI has become a widely used tool for measuring integrity in large-scale cortical networks.
Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content ( CS ) .
Intrinsic motivation and social support are important in enabling older people to overcome these challenges.
Intrinsic plasticity acts as a metaplasticity mechanism by lowering the threshold for synaptic changes.
Intrinsic plasticity can result from a change in the number , distribution or activity of various ion channels located throughout the neuron.
Intrinsic T-cell defects were caused by increased expression of dual-specific phosphatase @number@ ( DUSP4 ) .
Introducing juvenile apple snails ( ≤7 d old ) and mosquito fish ( 2-3 cm ) into the microcosm tanks initiated the exposure phase.
INTRODUCTION.
INTRODUCTION : A change in vital capacity ( VC ) from standing to supine can be an index of diaphragm paralysis if it exceeds @percent@.
INTRODUCTION : Activated microglia are associated with the progression of Alzheimer's disease ( AD ) , as well as many other neurodegenerative diseases of aging.
INTRODUCTION : Acute lower gastrointestinal bleeding ( ALGIB ) is a common event , which consumes considerable human and economic resources.
INTRODUCTION : Adaptive responses to exercise training ( ET ) are crucial in maintaining physiologic homeostasis and health span.
INTRODUCTION : A D-dimer ( DD ) test improves the diagnosis of PE ( PE ) when combined with clinical scores.
INTRODUCTION : Addressing chronic disease burden requires the creation of collaborative networks to promote systemic changes and engage stakeholders.
INTRODUCTION : Aesthetic medicine represents an emerging field for many specialties.
INTRODUCTION : Age-disparate sex has long been considered a factor that increases HIV risk for young women in South Africa.
INTRODUCTION : Age-related sarcopenia and dynapenia have negative effects on strength and the ability to perform activities of daily living.
INTRODUCTION : Aging has long been regarded as one of the most critical factors affecting crash injury outcomes.
INTRODUCTION : Aging involves a progressive reduction of respiratory muscle strength as well as muscle strength.
INTRODUCTION : Aging is a recognized risk factor for erectile dysfunction ( ED ) , contributing independently to vascular damage of penile tissue.
INTRODUCTION : Aging is associated with increased levels of circulating inflammatory markers and reduced muscle mass and strength.
INTRODUCTION : All elderly Germans are legally obliged to have health insurance.
INTRODUCTION : Although Latinos have lower hypertension rates than non-Latino whites and African Americans , they have a higher prevalence of undiagnosed and uncontrolled hypertension.
INTRODUCTION : Although testosterone deficiency has a well-known association with increased risk of cardiovascular disease ( CVD ) , the threshold remains to be determined.
INTRODUCTION : Alzheimer's disease ( AD ) is a primary and progressive neurodegenerative disorder , which is marked by cognitive deterioration and memory impairment.
INTRODUCTION : Alzheimer's disease ( AD ) is characterized by the accumulation of β-amyloid ( Aβ ) associated with brain atrophy and cognitive decline.
INTRODUCTION : Alzheimer's disease ( AD ) is the cause of more than two-thirds of all dementia cases.
INTRODUCTION : Alzheimer's Disease and Related Diseases ( ADRD ) are associated with a caregiver burden that increases with the progression of the disease.
INTRODUCTION : Ambient intelligence technologies are a means to support ageing-in-place by monitoring clients in the home.
INTRODUCTION : AMP-activated protein kinase ( AMPK ) maintains cultured chondrocyte matrix homeostasis in response to inflammatory cytokines.
INTRODUCTION AND HYPOTHESIS : Pelvic floor disorders are becoming more prevalent in the elderly population.
INTRODUCTION AND HYPOTHESIS : The aim was to review the economic costs associated with pelvic organ prolapse surgery.
INTRODUCTION AND HYPOTHESIS : The female pelvic floor is a complex network of ligaments and muscles whose mechanical properties have not been completely understood.
INTRODUCTION AND OBJECTIVE : Modern medicine is still searching for the antecedents which will lead to successful aging.
INTRODUCTION AND OBJECTIVE : Physical activity is an important factor in maintaining the health and functional fitness of elderly people.
INTRODUCTION AND OBJECTIVE : Protective antioxidative effects of melatonin have been repeatedly documented in experimental and clinical studies.
INTRODUCTION AND OBJECTIVES : The current and upcoming demographic change in industrial countries is a challenge for our society , economically as well as socially.
INTRODUCTION AND OBJECTIVES : The present study aimed to compare elderly and young female voices in habitual and high intensity.
INTRODUCTION AND OBJECTIVES : There is wide recognition of the importance of healthy eating in cardiovascular health promotion.
INTRODUCTION AND OBJECTIVES : The risk of stroke in atrial fibrillation is heterogeneous and depends upon underlying clinical conditions included in current risk stratification schemes.
INTRODUCTION AND RATIONALE : Influenza and pneumonia remain serious health concerns for long-term care ( LTC ) residents.
INTRODUCTION AND RATIONALE : The number of older cancer patients is increasing with global aging of the population.
INTRODUCTION : Androgen-deprivation therapy ( ADT ) is recognized to be the preferred first-line treatment for advanced prostate cancer.
INTRODUCTION : Approximately , @percent@ of HIV-infected individuals have comorbid diabetes.
INTRODUCTION : Apron controllers ( ACs ) determine the taxiways for aircraft entering the apron area until they reach their parking positions and vice versa.
INTRODUCTION : Around @percent@ of patients with major depression experience residual symptoms.
INTRODUCTION : As a part of aging , hip fractures are becoming more common.
INTRODUCTION : Associated with the increase in the aging population , there is an increase in the incidence of hip fractures worldwide.
INTRODUCTION : As the elderly population in the United States continues to grow , issues related to maintenance of health become increasingly important.
INTRODUCTION : Attendance at emergency departments and unplanned hospital readmissions are common for frail older patients after discharge from hospitals.
INTRODUCTION : Atypical femoral fractures ( AFFs ) are rare but a serious complication associated with prolonged use of bisphosphonates.
INTRODUCTION : Babesiosis is an emerging tick-borne disease ( TBD ) caused by Babesia microti , an intracellular parasite of red blood cells.
INTRODUCTION : Based on previous studies , a preclinical classification for Alzheimer's disease ( AD ) has been proposed.
INTRODUCTION : Behavioral and psychological symptoms in dementia ( BPSD ) are the principal sources of stress in caregivers.
INTRODUCTION : Benign prostatic hyperplasia ( BPH ) is a major health concern for aging men.
INTRODUCTION : Bone is an architecturally adaptive tissue which responds to mechanical loading.
INTRODUCTION : Brain detrimental effects are under-recognised complication of chronic heart failure ( CHF ) .
INTRODUCTION : Calcium silicate-based materials ( CSMs ) are used in various endodontic procedures.
INTRODUCTION : Caregiver support groups effectively reduce stress from caring for someone with dementia.
INTRODUCTION : Changes in personality differ qualitatively and quantitatively among patients with different neurodegenerative diseases , likely due to divergent patterns of regional neurodegeneration.
INTRODUCTION : Changes in the quality of bone material contribute significantly to bone fragility.
INTRODUCTION : Chronic cigarette smoking is associated with increased risk for Alzheimer's disease ( AD ) .
INTRODUCTION : Chronic conditions are the leading causes of death and disability worldwide.
INTRODUCTION : Chronic diseases associated with aging , such as arthritis , frequently cause reduced mobility , pain and diminished quality of life.
INTRODUCTION : Chronic obstructive pulmonary disease ( COPD ) is a progressive disease with a prevalence that increases with the aging of the subject.
INTRODUCTION : Chronic subdural hematoma ( CSDH ) is common and more prevalent in the aged population.
INTRODUCTION : Circadian alterations are prevalent in Alzheimer's disease ( AD ) and may contribute to cognitive impairment , behavioral symptoms , and neurodegeneration.
INTRODUCTION : Circulating inflammatory markers may play an important role in cognitive impairment at older ages.
INTRODUCTION : Cobalamin deficiency is frequent in elderly patients and the main aetiologies are food-cobalamin malabsorption and pernicious anaemia.
INTRODUCTION : Cognitive-communication disorders are common in individuals with traumatic brain injury ( TBI ) and can have a major impact on long-term outcome.
INTRODUCTION : cognitive deterioration and reductions of bone health coincide with increasing age.
INTRODUCTION : Cognitive training ( CT ) has been reported to improve cognition in older adults.
INTRODUCTION : Colon cancer therapy is primarily surgical.
INTRODUCTION : Colorectal cancer ( CRC ) is the third most common cancer in China.
INTRODUCTION : Comorbid obsessive-compulsive personality disorder ( OCPD ) is well-described in obsessive-compulsive disorder ( OCD ) .
INTRODUCTION : Congestive heart failure ( CHF ) , which typically affects older people , is characterized by high short- and mid-term mortality rates.
INTRODUCTION : Contradictory results have been reported on the relationship between orthostatic hypotension ( OH ) and mild cognitive impairment ( MCI ) .
INTRODUCTION : Controlled donation after circulatory death ( DCD ) remains ethically controversial.
INTRODUCTION : Controversial results on the relationship between the left-handedness and neurotic disturbances have been obtained in so far investigations.
INTRODUCTION : Controversies arise with respect to functioning of the middle ear over time.
INTRODUCTION : Co-occurrence with other chronic diseases may influence the progression of dementia , especially in case of multiple chronic diseases.
INTRODUCTION : Currently , ten million Americans are osteoporotic and an additional @number@ million have the precursor condition , osteopenia.
INTRODUCTION : Cushing's syndrome ( CS ) increases cardiovascular risk ( CVR ) and adipocytokine imbalance , associated with an increased inflammatory state.
INTRODUCTION : Dammarane triterpenoids , the main secondary metabolites of Panax ginseng , are very important natural compounds with remarkable biological activity.
INTRODUCTION : Data on the association between exercise capacity and risk for heart failure ( HF ) in older adults are limited.
INTRODUCTION : Deficits of balance or postural control in persons of advanced age are one of the factors that influence the risk of falling.
INTRODUCTION : Degenerative spine disorders are steadily increasing parallel to the aging of the population with considerable impact on cost and productivity.
INTRODUCTION : Delayed graft function ( DGF ) is a common complication in kidney transplantation.
INTRODUCTION : Delirium is common in critically ill patients and impact in-hospital mortality in patients with pneumonia.
INTRODUCTION : Depression is the most common psychiatric comorbidity in Parkinson's disease ( PD ) , but is often under-diagnosed and under-recognized.
INTRODUCTION : Despite high diabetes rates among Canadian First Nations people , little is known about their cardiovascular disease risk.
INTRODUCTION : Diabetes is an increasing problem among old people as well as being a contributing factor in their need for institutional care.
INTRODUCTION : Diabetic men with erectile dysfunction ( ED ) are less responsive to therapy with type @number@ phosphodiesterase ( PDE5 ) inhibitors.
INTRODUCTION : Diabetic urinary bladder disfunction is a common problem.
INTRODUCTION : DNA methylation is a key epigenetic mechanism in brain aging and Alzheimer's disease ( AD ) .
INTRODUCTION : Driving by the elderly is a growing reality , and an activity that helps to maintain a sense of personal freedom.
INTRODUCTION : Dual task ( DT ) training is becoming prominent in fall prevention.
INTRODUCTION : Due to aging of the general population , prevalence of Benign Prostatic Enlargement is increasing.
INTRODUCTION : During rowing , foot positioning on the foot stretcher is critical to optimise muscle force transmission and boat propulsion.
INTRODUCTION : Dysphagia is common in people living with dementia and associated with increased risk of aspiration pneumonia , dehydration , malnutrition , and death.
INTRODUCTION : Elderly men may suffer from late-onset hypogonadism ( LOH ) .
INTRODUCTION : Elderly Veterans enrolled in VA Home Based Primary Care ( HBPC ) programs suffer from many diseases including malnutrition.
INTRODUCTION : Electronic cigarettes ( e-cigs ) generate aerosols that users inhale.
INTRODUCTION : Emergency care of older adults requires specialized knowledge of their unique physiology , atypical presentations , and care transitions.
INTRODUCTION : Erectile dysfunction is highly prevalent in patients with advanced age or cardiovascular disease risk factors ( CVDRFs ) .
INTRODUCTION : Erogenous zones have paradoxical response properties , producing erotic feelings from body surfaces distant from the genitalia.
INTRODUCTION : Excess intakes of energy , sodium , saturated fat , and trans fat are associated with increased risk for cardiometabolic syndrome.
INTRODUCTION : Extensive clinical research has consistently shown statins lower the risk of cardiovascular events and mortality.
INTRODUCTION : Facial esthetics are important for self-esteem.
INTRODUCTION : Falls are a public health problem for the growing population of older adults.
INTRODUCTION : Falls are common among older adults.
INTRODUCTION : Females despairing of restless genital syndrome ( ReGS ) may request clitoridectomy for treatment of unwanted genital sensations.
INTRODUCTION : Fertility in women declines with increasing age.
INTRODUCTION : Fibromyalgia syndrome ( FMS ) is a multi-factorial disease involving physiological as well as psychological factors.
INTRODUCTION : First impressions are lasting , consequential and defined as the immediate judgment made of another from zero acquaintance.
INTRODUCTION : Foot disorders are common among older adults and may lead to outcomes such as falls and functional limitation.
INTRODUCTION : For many rural Canadians nursing care is the primary and often the sole access point to health care.
INTRODUCTION : Fractional laser technology is a new emerging technology to improve scars , fine lines , dyspigmentation , striae and wrinkles.
INTRODUCTION : Frailty is associated with a functional decline of multiple physiological systems , of which they may be a cause or consequence.
INTRODUCTION : Frailty is one of the most important concerns regarding our aging population.
INTRODUCTION : FRAX has been used to estimate osteoporotic fracture risk since @number@
INTRODUCTION : Glucagon-like peptide @number@ receptor ( GLP-1Rx ) agonists might elicit unwelcome side effects and concerns have recently been raised about their safety.
INTRODUCTION : Gout affects @percent@ of the UK's adult population and is now the most common type of inflammatory arthritis.
INTRODUCTION : Hearing impairment ( HI ) affects an estimated @number@ million people worldwide , with @percent@ of these living in developing countries.
INTRODUCTION : Heart disease and cancer are the first and second leading causes of death in the United States.
INTRODUCTION : High blood glucose levels may be responsible for the increased risk for dementia in diabetic patients.
INTRODUCTION : Hip fractures have long been recognized as a major public health concern.
INTRODUCTION : Hip geometry is expected to improve hip fracture risk assessment , which is usually assessed by bone mineral density ( BMD ) alone.
INTRODUCTION : Hydrocephalus is a complex neurological disorder with a pervasive impact on the central nervous system.
INTRODUCTION : Hyperpigmentation is a primary concern for many cosmetic patients because of its high rate of occurrence and significant impact on perceived age.
INTRODUCTION : Hypertension is a leading risk factor for development of heart failure , stroke and renal disease in the elderly.
INTRODUCTION : Hypertension is highly prevalent among the elderly.
INTRODUCTION : Hypertension is the most prevalent modifiable risk factor with a high prevalence among older adults.
INTRODUCTION : Iatrogenic bile duct injury is a serious complication of cholecystectomy.
INTRODUCTION : Immune response probably changes during human life , being influenced by cumulative exposure to environmental factors and individual genetic background.
INTRODUCTION : Improving the access to information on determinants of the smoking epidemic is essential for increasing the effectiveness of tobacco control policies.
INTRODUCTION : impulsivity in older people with cognitive impairment has yet to be examined rigorously as a risk factor for falls.
INTRODUCTION : Inadequacies in pain assessment and management in long-term care have been well documented.
INTRODUCTION : In clinical settings , neuropsychological test performance is traditionally evaluated with total summary scores ( TSS ) .
INTRODUCTION : In critically ill patients , it is uncertain whether exposure to older red blood cells ( RBCs ) may contribute to mortality.
INTRODUCTION : Indigenous elders have traditionally played an important role in maintaining social cohesion within their communities.
INTRODUCTION : Individuals differ in forearm length.
INTRODUCTION : In Europe the population is ageing rapidly.
INTRODUCTION : Infertility affects both women and men in all the countries.
INTRODUCTION : Inflammation and angiogenesis are known to play a role in the development prostate tumors.
INTRODUCTION : Inflammatory mechanisms and decreasing adrenal androgen production are involved in the pathogenesis of numerous age-related diseases.
INTRODUCTION : Information on anticipated survival time after dementia diagnosis among racially / ethnically diverse patients is needed to plan for care and evaluate disparities.
INTRODUCTION : In Italy , @percent@ of the elderly are estimated to have suffered abuse.
INTRODUCTION : Innovation in technology has resulted in the emergence of better , longer-lasting hyaluronic acid implants with fewer side effects.
INTRODUCTION : In South Africa , older adults make up a growing proportion of people living with HIV.
INTRODUCTION : Intakes of sodium , saturated fat , and trans fat remain high despite recommendations to limit these nutrients for cardiometabolic risk reduction.
INTRODUCTION : Internal thoracic artery ( ITA ) is an established arterial graft for the coronary artery by-pass surgery.
INTRODUCTION : In the contemporary U.S. , men and women are living longer and healthier lives.
INTRODUCTION : In the past , elderly patients with upper GI cancers were excluded from surgery or multimodal treatment only due to their advanced age.
INTRODUCTION : In today's aging population , diminished bone quality often affects the outcome of surgical treatment.
INTRODUCTION : It is well known that the prevalence of atrial fibrillation ( AF ) increases with age.
INTRODUCTION : Karachi falls into a low risk region for colorectal cancer ( CRC ) .
INTRODUCTION : Klotho variants ( KL-VS ) have been associated with increased longevity and better cognitive function.
INTRODUCTION : Knowledge about determinants of sexual activity in older adults in the general population is limited.
INTRODUCTION : Late-onset hypogonadism may impair quality of life and contribute to metabolic and cardiovascular comorbidity in aging men.
INTRODUCTION : Lexical fluency tests are frequently used in clinical practice to assess language and executive function.
INTRODUCTION : Limited information is available concerning the general and sexual health status of European men.
INTRODUCTION : Little is known about risperidone metabolism in a clinical sample , where polypharmacy is common.
INTRODUCTION : Little is known about the public health impact of the NOF Guidelines.
INTRODUCTION : Little research has been done on elderly adults from an optimistic perspective.
INTRODUCTION : Longevity is commonly associated with good health and with delayed onset of age-related diseases with usually benign course.
INTRODUCTION : Longitudinal changes in serum 25-hydroxyvitamin D ( 25-OHD ) levels during aging have not been studied extensively.
INTRODUCTION : Loss of lumbar extensor muscle strength and fatigue resistance may contribute to functional disability.
INTRODUCTION : Lower limbs anatomical and biomechanical parameters are essential in several paediatric orthopaedic disease , which makes their exact measurement necessary.
INTRODUCTION : Lung cancer is the highest cause of mortality among tumor pathologies worldwide.
INTRODUCTION : Management of patients with poor bone stock remains difficult due to the risks of mechanical complications such as screws pullouts.
INTRODUCTION : Many human diseases result from a failure of a single protein to achieve the correct folding and tertiary conformation.
INTRODUCTION : Many individuals with Alzheimer's disease ( AD ) live alone , and this figure is expected to increase.
INTRODUCTION : Many older drivers self-restrict or avoid driving under high-risk conditions.
INTRODUCTION : Many relationships in bone metabolism and homeostasis are likely to follow non-linear patterns.
INTRODUCTION : Medical and public health societies advocate that healthcare providers ( HCPs ) counsel at-risk patients to reduce firearm injury risk.
INTRODUCTION : Migraine is a highly prevalent and disabling neurological condition whose personal , social and economic impact is substantial.
INTRODUCTION : Minimally invasive procedures in carotid endarterectomy are currently preferred.
INTRODUCTION : Mobile technology , when included within multicomponent interventions , could contribute to more effective weight loss.
INTRODUCTION : Multiple factors may affect bone mineral density ( BMD ) .
INTRODUCTION : Multiple object tracking ( MOT ) is a powerful paradigm for measuring sustained attention.
INTRODUCTION : Myofiber type grouping is a histological hallmark of age-related motor unit remodeling.
INTRODUCTION : Negative life events and lack of social support are associated with depression in the elderly.
INTRODUCTION : Neonatal hypoxic ischemic encephalopathy ( HIE ) is a devastating neurologic condition with high mortality rates and long-term complications for surviving infants.
INTRODUCTION : No data are available for normative values of cutaneous threshold and spatial discrimination in the feet.
INTRODUCTION : Non-Alcoholic Fatty Liver Disease ( NAFLD ) is related to unhealthy habits , mainly to unfavorable dietary profiles.
INTRODUCTION : Non-pharmacological therapies for common chronic medical conditions in older patients are underused in clinical practice.
INTRODUCTION : no previously published botulinum toxin type A cosmetic trials included both physician and subject measures of onset.
INTRODUCTION : Normative tables for assessment of grip and pinch strength were developed @number@ years ago and are likely outdated.
INTRODUCTION : Obesity is the principal component in the Metabolic Syndrome ( MetS ) that determines the progression of metabolic complications.
INTRODUCTION : OBJECTIVES : Specific diets or lifestyles have an impact on cognitive function in previous studies.
Introduction of geriatric care standards is required to improve health outcomes for older patients.
Introduction of mouthwash instead of water or ethanol solution resulted in a significant reduction in the coefficient of friction.
Introduction of virtual reality tasks makes it possible to easily assess cognitive functions such as spatial memory , a hippocampus-dependent cognitive ability.
INTRODUCTION : Older adults often show declines in phonological aspects of language production , particularly for low-frequency words , but maintain strong semantic systems.
INTRODUCTION : Older men and women with T2DM are at increased risk for fracture despite normal bone mineral density ( BMD ) .
INTRODUCTION : Old people attend emergency departments ( ED´s ) in increasing numbers.
INTRODUCTION : One in ten women over the age of @number@ will develop breast cancer.
INTRODUCTION : One out of three persons aged @number@ and older falls annually and @percent@ to @percent@ of falls result in injury.
INTRODUCTION : Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures.
INTRODUCTION : Osteoarthritis ( OA ) is associated with increased bone formation at a local site.
INTRODUCTION : Osteoporosis , a disease characterized by the progressive loss of bone tissue , is one of the most common complications of aging.
INTRODUCTION : ovarian cancer is deadly and frequently affects older patients.
INTRODUCTION : Ovarian fibroma is a benign stromal tumour composed of spindle / ovoid fibroblastic cells producing collagen.
INTRODUCTION : Overactive bladder ( OAB ) represents a disruption in the storage function of the lower urinary tract.
INTRODUCTION : Oxidative stress has been implicated in the pathogenesis of osteoporosis.
INTRODUCTION : Pain is the primary outcome measurement in osteoarthritis , and its assessment is mostly based on its intensity.
INTRODUCTION : Patients with late onset hypogonadism ( LOH ) also suffered from lower urinary tract symptoms ( LUTS ) and LOH symptoms.
INTRODUCTION : Penile rigidity depends on maximizing inflow while minimizing outflow.
INTRODUCTION : Photodynamic therapy was introduced as an adjuvant to conventional chemo-mechanical debridement during endodontic treatment to overcome the persistence of biofilms.
INTRODUCTION : Physical activity ( PA ) is beneficial for general health.
INTRODUCTION : Physical and cognitive function decline with age , accelerating during the 6th decade.
INTRODUCTION : Physical and mental changes associated with aging commonly lead to a decrease in communication capacity , reducing social interactions and increasing loneliness.
INTRODUCTION : Physical rehabilitation is commonly used in patients with Parkinson's disease ( PD ) to improve their health and alleviate the symptoms.
INTRODUCTION : Polish ageing society still experiences health-related problems and the increasing difficulties in receiving medical care.
INTRODUCTION : Population aging has become a global phenomenon , and HIV infection among older individuals is also increasing.
INTRODUCTION : Population aging is a feature of all countries in the world.
INTRODUCTION : Population aging is a worldwide phenomenon.
INTRODUCTION : Population aging translates into more people with chronic non-communicable diseases , disability , frailty and dependency.
INTRODUCTION : Population-level survival has improved for common haematologic malignancies in the early 21st century.
INTRODUCTION : Postmenopausal women's knowledge about vulvar and vaginal atrophy ( VVA ) and available treatment options has historically been inadequate.
INTRODUCTION : Predictors of functional independence in older adults are in need.
INTRODUCTION : Preliminary evidence suggests that hypercholesterolemia is associated to an increased risk to develop hypertension.
INTRODUCTION : Previous studies have identified common germline variants nominally associated with breast cancer survival.
INTRODUCTION : Previous studies have identified hyperlipidemia as a potential risk factor for dementia and Alzheimer's disease.
INTRODUCTION : Primary care in the United States faces unprecedented challenges from an aging population and the accompanying prevalence of chronic disease.
INTRODUCTION : Prodromal markers of Alzheimer's disease ( AD ) have been derived from wakefulness.
INTRODUCTION : Productivity loss is an increasing problem in an aging working population that is decreasing in numbers.
INTRODUCTION : Progressive bulbar motor neuropathy is primarily caused by bulbar-onset ALS.
INTRODUCTION / PURPOSE : Aging modifies neuromuscular activation of agonist and antagonist muscles during walking.
INTRODUCTION : Quantitative ultrasound can measure skeletal muscle pathology.
INTRODUCTION : Radiofrequency has remained a staple procedure for the treatment of skin laxity as therapeutic heat thresholds effectively promote collagen remodeling.
INTRODUCTION : Recent genome-wide association studies have explored some new loci in association with Parkinson's disease ( PD ) .
INTRODUCTION : Recent literature proposes that amyloid β ( Aβ ) and phosphorylated tau ( p-tau ) synergism accelerates biomarker abnormalities in controls.
INTRODUCTION : Reference values to define cognitive impairment in individuals aged @number@ years and older are lacking.
INTRODUCTION : Renal osteodystrophy leads to increased morbidity and mortality in patients with CKD.
INTRODUCTION : Repeatability and variability of the plantar pressure during walking are important components in the clinical assessment of the elderly.
INTRODUCTION : Resting state networks are proposed to reflect the neuronal connectivity that underlies cognitive processes.
INTRODUCTION : Rugby is one of the most tactically complex sports.
INTRODUCTION : Sarcoidosis is a multi-organ system granulomatous disease of unknown origin with an incidence of 1-40 / 100 , 000.
INTRODUCTION : Sarcopenia is a chronic condition that is associated with aging and characterized by a reduction of muscle mass , strength , and function.
INTRODUCTION : Sarcopenia is characterized by an involuntary loss of skeletal muscle mass , strength , and function.
INTRODUCTION : Sarcopenia is currently best described as an age-related decline in skeletal muscle mass and function.
INTRODUCTION : Sarcopenia is disproportionately present in older women with disability , and optimum treatment is not clear.
INTRODUCTION : Scientific evidence indicates that adherence to the Mediterranean diet protects against the deterioration of cognitive status and depressive symptoms during aging.
INTRODUCTION : Scientific evidence shows that cigarette price increases can significantly reduce smoking prevalence and smoking initiation among adolescents and young adults.
INTRODUCTION : Sclerostin , produced by osteocytes , is a potent inhibitor of Wnt signaling and bone formation.
Introduction SE is a topic of vital importance to individual employees , organizations and society alike.
INTRODUCTION : Self-rated health is an individual and subjective conceptualization involving the intersection of biological , social and psychological factors.
INTRODUCTION : Self-Rated Health is part of the comprehensive concept of Quality of Life and is a valid measurement of health status.
INTRODUCTION : Self-screening by older drivers has shown considerable promise for increasing self-awareness about functional abilities associated with safe driving.
INTRODUCTION : Several studies have documented increased cardiovascular risk factors , particularly hypercholesterolemia , in the migraine population with respect to controls.
INTRODUCTION : Sex differences have been identified in antidepressant treatment ; however , it remains unclear to what extent pharmacokinetics contributes to these differences.
INTRODUCTION : Sex hormones have been implicated in the etiology of a number of diseases.
INTRODUCTION : Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models.
INTRODUCTION : Since the introduction of fractional technology , various systems were launched to the market.
INTRODUCTION : Sirtuins are an evolutionarily conserved family of NAD ( + ) -dependent protein lysine deacylases.
INTRODUCTION : Skin diseases in the aging population vary and are a key concern for clinicians in terms of diagnosis , management and follow-up.
INTRODUCTION : Skin resurfacing is an accepted gold standard for the treatment of skin laxity , photodamage , and appearance of visible lines and wrinkles.
INTRODUCTION : Sleep is a complex phenomenon characterized by important modifications throughout life and by changes of autonomic cardiovascular control.
INTRODUCTION : Social cognition refers to mental processes that operate in situations of social interaction and facilitate adjustment and functioning in such scenarios.
INTRODUCTION : Social representations ( SRs ) contain @number@ dimensions : information , attitude , and field.
INTRODUCTION : Solar elastosis , or basophilic degeneration of collagen , may be a histologic sign of chronic sun damage.
INTRODUCTION : Soluble mesothelin ( SM ) and megakaryocyte potentiating factor ( MPF ) are serum biomarkers of mesothelioma.
INTRODUCTION : Stroke is a chronic condition that necessitates multidimensional and overwhelming care.
INTRODUCTION : Studies analyzing the moderator role of self-efficacy have centered their attention on the relationship between stressors and distress.
INTRODUCTION : Studies designed in northern countries show that most women are still sexually active after the age of @number@
INTRODUCTION : Studies have associated the metabolic syndrome with poor sexual function ; the results , however , are controversial.
INTRODUCTION : Studies have shown that perceived discrimination has an impact on our physical and mental health.
INTRODUCTION : Studies on the associations between cognitive abilities and life satisfaction ( LS ) in the oldest-old are few.
INTRODUCTION : Subjective memory complaints are common with aging.
INTRODUCTION : Suicide rates among middle-aged men and women in the U.S. have been increasing since @number@ with a sharp escalation since @number@
INTRODUCTION : Susceptibility to muscle fatigue during aging could depend on muscle activation patterns.
INTRODUCTION : The adjustment process to visual impairment can be approached by using theoretical models.
INTRODUCTION : The administration of stem cells holds promise as a potential therapy for spinal cord injury ( SCI ) .
INTRODUCTION : The ageing population increases the prevalence of sarcopenia.
INTRODUCTION : The aging population and the growing use of technology are two realities of modern society.
INTRODUCTION : The aging population is growing rapidly in Asia resulting in an increased number of fragility fractures.
INTRODUCTION : The aging population is growing rapidly in Asia resulting in an increased number of hip fractures being managed surgically.
INTRODUCTION : The aging process is accompanied by several changes , such as a decrease in physical fitness.
INTRODUCTION : The aim of our research was to quantify the presence of totally sclerotized glomeruli during the aging process.
INTRODUCTION : The aim of this study is to report our 6-year single-center experience with L5-S1 axial lumbar interbody fusion ( AxiaLIF ) .
INTRODUCTION : The aim of this study was to evaluate the role of oxidative stress in the process of ovarian aging.
INTRODUCTION : The APOE e4 allele has been linked to poorer cognitive aging and enhanced dementia risk.
INTRODUCTION : The bone-specific physical activity questionnaire ( BPAQ ) was developed to account for bone-specific loading.
INTRODUCTION : The burden of diabetes and cardiovascular disease among the Canadian First Nation population is disproportionately high compared with the general Canadian population.
INTRODUCTION : The cerebrospinal fluid ( CSF ) plays a major role in the physiology of the central nervous system.
INTRODUCTION : The cervical vertebrae maturation ( CVM ) method is used to determine the timing of treatment of Class II malocclusion.
INTRODUCTION : The CMAP scan is a surface EMG method based on the successive activation of motor units.
INTRODUCTION : The cognitive reserve theory may contribute to explain cognitive performance differences among individuals with similar cognitive decline and among healthy ones.
INTRODUCTION : The @date@ disaster was unparalleled in the disaster history of Japan.
INTRODUCTION : The demand for long-term care ( LTC ) services is likely to increase as a population ages.
INTRODUCTION : The developed world has an aging population with an increasing neurosurgical demand.
INTRODUCTION : The development of functional limitations among adults aged @number@ or older has profound effects on individual and population resources.
INTRODUCTION : The digital divide affecting elderly patients may compromise the diffusion of telemedicine systems for this age segment.
INTRODUCTION : The economic impact of smoking for California's Hispanic population for @number@ was estimated.
INTRODUCTION : The elderly are subject to natural aging and the health problems caused by the recession of physical and mental functions.
INTRODUCTION : The elderly population is growing and aging in better clinical conditions than in the past.
INTRODUCTION : The European Haemophilia Consortium ( EHC ) is an international non-profit organization representing @number@ national patients ' organizations in Europe.
INTRODUCTION : The evidence on the association between socioeconomic status and hip fracture incidence is limited and inconsistent.
INTRODUCTION : The executive function is a complex set of skills affected during the aging process and translate into subclinical cerebrovascular disease.
INTRODUCTION : The feasibility and validity of brief computerized cognitive batteries at the population-level are unknown.
INTRODUCTION : The feeding behavior establishes a relation of humans with food , includes food habits that could be involved with oxidative stress.
INTRODUCTION : The incidence and treatment of prostate cancer in male renal-transplant patients has not been extensively evaluated.
INTRODUCTION : The incidence of end-stage renal disease is increasing worldwide.
INTRODUCTION : The most common reconstruction materials for orbital floor fractures are PDS ( polydioxanone ) foil and titanium meshes.
INTRODUCTION : The most effective type of social participation against psychological distress in older adults is not well documented.
INTRODUCTION : The number of older patients with cancer is increasing.
INTRODUCTION : The objective of this article was to estimate the age at death in forensic or anthropologic applications based on human skull investigation.
INTRODUCTION : The piriform cortex and cortical amygdala ( PCA ) and the orbitofrontal cortex ( OFC ) are considered olfactory-related brain regions.
INTRODUCTION : The presence of cerebrovascular pathology may increase the risk of clinical diagnosis of Alzheimer's disease ( AD ) .
INTRODUCTION : The prevalence and negative health effects of chronic diseases are disproportionately high among Hispanics , the largest minority group in the United States.
INTRODUCTION : The prevalence of nonhealing wounds is predicted to increase due to the growing aging population.
INTRODUCTION : The progress and determinants of sexual dysfunction in middle-aged and elderly men remain unclear.
INTRODUCTION : The rate of hip fracture varies by age and ethnicity.
INTRODUCTION : There is a lack of data regarding the appropriateness of transperitoneal and retroperitoneal approaches for right-sided laparoscopic adrenalectomy.
INTRODUCTION : There is an age-related conversion of red to yellow bone marrow in the axial skeleton , with a gender-related difference less well established.
INTRODUCTION : There is increasing need to understand patient-centred outcomes in osteoporosis ( OP ) clinical research and management.
INTRODUCTION. The relationship among lifestyle , aging and psychological wellbeing was evaluated in Japanese working men.
INTRODUCTION : The relationship between erectile dysfunction ( ED ) and depressive symptoms is well established.
INTRODUCTION : The relationship between fiber size and myonuclear content is poorly understood.
INTRODUCTION : The relationships between oral health conditions and frailty have rarely been explored.
INTRODUCTION : The risk of tendon injury and disease increases significantly with increasing age.
INTRODUCTION : The role of spirituality in the context of mental health and successful aging is not well understood.
Introduction The search for a reliable neuroimaging biomarker in Alzheimer's disease is a matter of intense research.
INTRODUCTION : The skeletal system has high metabolic activity.
INTRODUCTION : The Social Adaptation Self-evaluation Scale ( SASS ) is used to measure social function and social motivation in depressed patients.
INTRODUCTION : The status of dementia diagnosis and treatment of neurology outpatients in general hospitals in China remains unclear.
INTRODUCTION : The study aimed to determine the effect of group exercise frequency on health related quality of life in institutionalized elderly.
INTRODUCTION : The survival of patients with chronic myelocytic leukemia ( CML ) has improved during the past decades.
INTRODUCTION : The term cognitive reserve describes the capacity of the adult brain to minimise the clinical manifestation of a neurodegenerative process.
INTRODUCTION : The use of antiepileptic drugs ( AEDs ) in older patients with epilepsy is challenged by polypharmacy and decreased drug elimination.
INTRODUCTION : The use of hospital care increases significantly with age.
INTRODUCTION : The value of clinically available free testosterone ( FT ) assays remains controversial.
INTRODUCTION : The western population is ageing.
INTRODUCTION : The worldwide population is aging , and several age-associated physiological and pathophysiological changes can affect drug disposition.
INTRODUCTION : This case study aims to make an assessment of environmental health nuisances in textile industry in the Democratic Republic of Congo.
INTRODUCTION : This consensus article reviews the therapeutic strategies and management options for the treatment of osteoporosis of the oldest old.
INTRODUCTION : This study aimed at assessing the reliability and construct validity of the TCI-140.
INTRODUCTION : This study aimed to evaluate the incidence of complications in elderly patients with a hip fracture following integrated orthogeriatric treatment.
INTRODUCTION : This study aims to evaluate the impact of iron deposition during aging on the measurement of water diffusion in the brain.
INTRODUCTION : This study was conducted to investigate the geographic trends of the incidence of osteoporotic hip fractures through a comprehensive review of literature.
INTRODUCTION : This study was designed to identify predictors of pain and declines in function among elderly patients following a fall-related hip fracture.
INTRODUCTION : Though the clinical significance of testosterone deficiency is becoming increasingly apparent , its prevalence in the general population remains unrecognised.
INTRODUCTION : Tobacco use remains a leading modifiable cause of cancer incidence and premature mortality in the U.S. and globally.
INTRODUCTION : To compare the 12-month choroidal thickness ( CT ) change between Alzheimer disease ( AD ) patients and normal subjects.
INTRODUCTION : To examine the effect of age and sex steroids on bone density and geometry of the radius in two European Caucasian populations.
INTRODUCTION : Translational prostate cancer research is hampered by long intervals from diagnosis to patient progression and difficulty in obtaining cancer tissue for investigation.
INTRODUCTION : Treatment of patients with traumatic brain injury ( TBI ) should be based upon the strongest evidence to achieve optimal patient outcomes.
INTRODUCTION : Ultra-short telomeres caused by stress-induced telomere shortening are suggested to induce chondrocyte senescence in human osteoarthritic knees.
INTRODUCTION : Ultrasonography can detect structural muscle changes caused by neuromuscular disease , but it has not yet been applied to facial nerve diseases.
INTRODUCTION : Ultrasound-acquired internal carotid arterial ( ICA ) pulsatility indices ( PI ) have been demonstrated to be useful measures of cerebrovascular disease.
INTRODUCTION : Ultraviolet irradiation has deleterious effects on human skin , including tanning , sunburn , cancer and connective tissue degradation ( photoaging ) .
INTRODUCTION : Understanding sexual behavior is important when evaluating the health needs of older adults.
INTRODUCTION : U.S. smoking prevalence has been declining over the last several decades.
INTRODUCTION : Vaccination is an effective preventive strategy against influenza.
INTRODUCTION : Value analysis in health care calculates the economic value added ( EVA ) that results from improvements in health and health care.
INTRODUCTION : Various operational definitions have been proposed to assess the frailty condition among older individuals.
INTRODUCTION : Volume restoration is not a new concept in facial rejuvenation.
INTRODUCTION : We compared the region-specific neuromuscular activation and muscle morphology along the rectus femoris ( RF ) muscle between young and elderly.
INTRODUCTION : We determined lower limb neuromuscular capacities associated with falls and fall-related injuries in older people with declining peripheral nerve function.
INTRODUCTION : We evaluated the association between serum sex hormone levels and prostate volume in Taiwanese men.
INTRODUCTION : We examined whether statins are associated with better cerebral white ( WM ) and gray matter ( GM ) indices in community-dwelling elders.
INTRODUCTION : We investigated the clinical differences between familial and sporadic frontotemporal dementia ( FTD ) , screening for mutations in known FTD genes.
INTRODUCTION : While there is consensus on how to treat acute appendicitis , the most suitable treatment for an appendiceal inflammatory mass is still debated.
INTRODUCTION : With a rapidly aging society , geriatric mental health is emerging as an important public health concern.
INTRODUCTION : With the aging of the population , an increasing number of people have dementia , most of whom are receiving home care.
INTRODUCTION : Working memory ( WM ) is a multi-component model that among others involves the two processes of filtering and storage.
INTRODUCTION : Xeroderma pigmentosum ( XP ) is a rare autosomal recessive disease caused by mutations resulting in defective repair of DNA damage.
Intronic MAPT mutations altering exon @number@ splicing lead mainly to an increase of 4Rtau.
In TTC , BNP / NT-Pro-BNP therefore serves as an ancillary diagnostic measure as well as a marker of recovery.
\ "Intuitively , standing seems simpler than walking. \ "
In tumors \ "not ultralow risk , \ " tumor size greater than @number@ cm was the most predictive of outcome.
In turn , AGO2-let-7 triggered target mRNA decay.
In turn , at case level , comorbid symptoms of anxiety are associated with higher levels of depressive symptoms and more functional disability.
In turn , baseline physical impairment was only marginally associated with rate of cognitive decline across various cognitive domains.
In turn , cellular NAD parameters may affect the generation of ATP , a main cellular currency of energy.
In turn , exposure biomarkers can be temporarily categorized into markers of acute , medium term or chronic effects.
In turn , facial fat was believed to be a contiguous sheet of tissue.
In turn , higher serum free triiodothyronine levels were related to higher production capacity of pro-inflammatory cytokines after stimulation with lipopolysaccharide.
In turn , impaired cerebral vasomotor reactivity is a risk factor for stroke in clinical populations.
In turn , increased caregiver depression and decreased caregiver respectful behavior predicted increases in potentially harmful behavior.
In turn , increases in control were predicted by better initial health and more support.
In turn , infections alter nutrient status and can create a deficiency state.
In turn , p63 is essential for the development of stratified epithelia and may also play a part in neuronal survival and aging.
In turns and reversals , although on average there was no consistent direction preference , we observed significant individual biases.
In turn , signaling through phosphorylated extracellular signal-regulated protein kinases is affected along with an age-independent increase in phosphorylated cAMP response element-binding protein.
In turn , SREBF1 expression was directly associated with HDL cholesterol ( P-value = @number@ ) .
In turn , such hemodynamic deficits may adversely affect brain function and clinical course.
In turn , these can allow quantitative assessment and enable imagers to more directly compare the findings of patients at earlier stages of disease.
In turn , these practices affirmed the gendered nature of possession and care work into another generation.
In turn , these proteins - as oligomers or in aggregated forms - cause mitochondrial impairment by apparently following similar mechanisms.
In turn , these provide individuals with meaning in life.
In turn , these scores predicted greater improvements in exercise capacity concurrently and @number@ months later.
In turn this genetic variation may contribute to cortisol-associated degenerative diseases.
In turn , women and older men prefer cereal products as basic functional carriers.
In turn , you and your patients will achieve quick and long-term success.
In two experiments , older adults exhibited comparable specificity reductions across all conditions.
In two experiments , participants read statements that contradicted information stored in memory ; a post-experimental knowledge check confirmed what individual participants knew.
In two experiments recognition of actions of a robbery presented in a video was examined in older and younger adults.
In two experiments , the authors explored whether there are any age differences associated with the ability to process outdated information during news reports comprehension.
In two experiments we compared the effects of aging to the effects of division of attention in younger adults on memory for items and context.
In two experiments , we examined spacing effects on the learning of bird families and metacognitive assessments of such learning.
In two experiments we found age differences in the ability to perceive hierarchical structure in continuous activity.
In two experiments , we investigated age-related changes in how prosodic pitch accents affect memory.
In two experiments , we investigated the underlying cause in further detail.
In two experiments we present a novel paradigm of conceptual associative priming in which subjects make speeded associative judgments about unrelated objects.
In two experiments , we tested competing predictions derived from two theoretical accounts of stereotype threat : executive-control interference and regulatory fit.
In two experiments , younger and older participants studied faces , names , and occupations that were of differing social value.
In two independent samples , locus 12q24 was also associated with coronary heart disease and hypertension.
In two mouse models , treatment with rapamycin abolishes the AD pathology and reverses memory deficits.
In two patients due to acute retention urinary catheter was inserted.
In two studies , older and younger adults ' generative concern was examined following mortality or control primes.
In two studies , older and younger adults ' generative concern was examined following mortality or control primes.
In two studies , we tested whether ApOE genotype affects memory for everyday activities.
In type D , there is no alteration in ADH secretion.
In typical development , imitation plays a key role in sociocognitive competence.
In Uganda , WLHIV reported lower rates of sexual activity and rated sex as less important than men.
In unadjusted analyses , the age effect was statistically significant in long-term cancer survivors only.
In unadjusted analyses , the three EF measures were related to gait speed in single- and dual-task conditions.
In undamaged human dermal fibroblasts ( HDF ) , 53BP1 is a nucleoskeleton protein.
In unfair lineups , ability to discriminate between innocent and guilty suspects was poor in all age groups.
In univariate analyses higher levels of log-transformed MCP-1 and TNF-α were associated with the presence of CAC ( p < 0.05 ) .
In univariate analyses , this condition was associated with female gender , lifetime anxiety disorder and living alone.
In univariate analysis , change in all the studied hormones , except for E2 , was significantly associated with cognitive decline.
In univariate analysis , SFCT increased by @number@ μm ( @percent@ confidence interval : @number@ @number@ ) for each mm Hg increase in CSFP.
In univariate logistic regression analysis and multivariate analysis , overall self reported and comparative satisfaction with life was more satisfactory among the oldest elderly.
In univariate logistic regression analysis , TC diagnosis was associated with inadequate levels of vitamin D ( p = .047 ) .
In up-and-reach ( UR ) , subjects stood up from a seated position and then reached forward.
In urban areas , the unhealthy weight burden was largely underweight in childhood and overweight in adulthood.
In utero exposure during the fetal period induced limb reduction defects of vascular origin.
In UVB-irradiated human dermal fibroblasts treated with EG , MMP-1 production considerably decreased without cell toxicity.
In validation-phase studies , we observed a strong association between plasma ApoE concentration and Aβ burden in the medial temporal lobe.
In vascular dementia , cholinergic reductions are correlated with cognitive impairment , and cholinesterase inhibitors have some benefit.
Invasive aspergillosis ( IA ) is a serious hazard to high-risk haematological patients.
Invasive bacterial diseases such as pyelonephritis and bacteremic bacteriuria are also \ "UTIs. \ "
Invasive pneumococcal disease ( IPD ) carries a high case fatality rate.
Inverse associations of fat with dementia were attenuated by weight change from midlife and were strongest in women with midlife BMI < 25.
Inverse associations were also found between serum ascorbate and nuclear cataract and posterior subcapsular cataract.
Inverse associations were found for consumption of wine and liquor , but not beer.
Inverse correlations between body mass index ( BMI ) and brain volumes suggest that lean bodies may be associated with increased cortical volume.
Inverse dynamic analyses were used to calculate 3-D hip joint torques of the trail and lead limbs.
Inversely , absence of Lsd1 enzymatic activity concomitant with knockdown of Sirt4 reestablishes normal glutamine anaplerosis , redox balance and mitochondrial function.
Inversely , blocking of autophagy led to an accumulation of this oligomeric species and increased cell death.
Inversely , heat exchange is enhanced and body heat production is reduced when avoiding hyperthermia.
Inversely , overall male cancer crude mortality rate showed a @percent@ decrease , mostly due to mortality risk.
Inverse probability weighting suggests the generalizability of these results to nonautopsied cohorts.
Inverse probability weighting was used to account for selective attrition and time-varying confounding of incident diabetes.
Inverse probability weighting was used to adjust for nonparticipation.
Inversion impaired performance on the normality task but not the discrimination task and eliminated the young adult advantage in the normality task.
In vertebrates , skeletal muscle is derived from mesodermal structures called somites.
In very degenerate OA specimens , with significant disruption of the articular surface , staining was distributed throughout most of the cartilage matrix.
In very old people , life expectancy and functionality are the most important factors for guiding potential treatments.
In very old people with good cognitive function , multimorbidity predicts accelerated increase in ADL disability.
Investigated muscle properties included torque amplitudes and muscle contraction timings.
Investigating how Parkin induces these changes may offer insight into the mechanisms that lead to the sequestration and elimination of damaged mitochondria.
Investigating self-presentational concerns in older women may provide novel ways to impact balance-related outcomes in this population.
Investigating the acute impact of light on clock-gene expression may thus help us to better understand the mechanisms underlying disorders rooted in the circadian system.
Investigating the interactions of RNA-binding proteins ( RBPs ) with RNAs is a complex task for molecular and computational biologists.
Investigating the mechanism of brain development during these periods in healthy people is necessary for some clinical purposes.
Investigating the molecular genetic mechanism of CAH can improve recognition and optimize diagnosis of this disease.
Investigating the most likely causal variants identified by fine-mapping analyses may improve the power to detect gene-environment interactions.
Investigating the predictors of age-related cognitive change is a research priority.
Investigation focusing on radiation-induced changes of critical brain development events may reveal many previously unknown adverse effects.
Investigation for novel therapeutic approaches targeting the presumed underlying pathogenic mechanisms is major focus of research.
Investigation of cell-cycle kinetics in mammalian pancreatic β cells has mostly focused on transition from the quiescent ( G0 ) to G1 phase.
Investigation of medical patients ' status relevant to this phenomenon needs to be continued.
Investigation of navigation skills should include measurement of cognitive-executive and motor aspects , which are part of complex tasks.
Investigation of novel penalty functions may prove fruitful in further refining psychiatric phenotypes.
Investigation of processes regulating age-related accumulation of isomerized proteins is a promising avenue to a better understanding of aging at the protein level.
Investigation of rhythmic IHG protocols warrants further examination.
Investigation of spiked beers led us to highlight the key role of pro-oxidants and acetaldehyde.
Investigation of the mechanisms contributing to this apparent age differential in risk could have important mental illness treatment implications in this population.
Investigation of the modulation of fibroblast contraction by these ingredients requires the implementation of three-dimensional in situ imaging methodologies.
Investigation of the relative importance of such mechanisms is an important topic for further study.
Investigations are needed to determine how these effects compare with those elicited from aerobic exercise training and / or standard treatments.
Investigations into the metabolic effects of resveratrol are furthest along and now include a number of clinical trials , which have yielded mixed results.
Investigations using receptor specific agonists suggest that all three receptors rapidly activate kinase-signaling and have complex dose-dependent influences on memory.
Investigator and patient satisfaction was stated in more than @number@ percent of cases as excellent / good.
Investigator and subject assessments both indicated high levels of treatment satisfaction.
Investigator and subject assessments of wrinkle severity at maximum frown and repose using 4-point scales and adverse events were conducted.
Investigator and subject ratings of ' much improved ' or ' excellent ' improvement were reported using 2-D photographs as a visual aid.
Investigator-defined individualized HbA1c targets and the impact of baseline characteristics on individualized treatment targets was evaluated.The average individualized HbA1c target was set at @percent@.
Investigator , independent evaluator and subjects assessed results at four time points.
Investigator questionnaires showed a clear and statistically significant preference for Artiste over manual injection in all parameters ( P < @number@ ) .
Investigators and subjects assessed CFL severity ( maximum smile and rest ) using the 4-grade Facial Wrinkle Scale ( FWS ) .
Investigators collected data from reviews of resident health records and interviews with SDMs at baseline and 3-month follow-up.
Investigators collected @number@ salivary cortisol samples throughout a 2-hour afternoon visit involving exposure to the Trier Social Stress Test modified to maximize between-sex differences.
Investigators extracted data on study characteristics , outcome measures , and methodological quality.
Investigators face many challenges that may greatly affect the outcomes of research on pharmacotherapy in older adults.
Investigators have previously hypothesized that statin antioxidant effects may slow the natural aging process of the lens.
Investigators operating registries may need to offer particular assurances about data security to maximize registry enrollment but also must carefully manage participant expectations.
Investigators used content analysis and quantization to examine the word association data and statistical tests to analyze the mental health subscale ( ERA-MHS ) .
Investing in strategies that address staff attitude and encourage person-centred care could influence sense of competence , and by extension , dementia care.
Investment personality traits are thought to positively affect cognitive performance in old age , even after controlling for prior cognitive ability.
Investments in social connections and healthy behaviors ( religious involvement , alcohol use , and exercise ) also produced positive returns in health stock.
Investments to improve nutrition make a positive contribution to long-term national and global health , economic productivity and stability , and societal resilience.
In Vietnam , raw fish dishes are also traditionally prepared and consumed in private households.
In view of age-related changes in attentional demands of motor control , both elderly and young adults were tested.
In view of an increasingly aging population the prevalence of dementia is also expected to increase rapidly.
In view of a worldwide aging population and the fact that increased incidence rates are associated with higher age , new socioeconomic challenges will appear.
In view of its diverse toxicology , the possibility that cannabis-exposed patients may be ageing more quickly requires investigation.
In view of population aging , better understanding of what drives long-term care expenditure ( LTCE ) is warranted.
In view of significantly different rating scores , a photographic reference for assessment of sun damage is also necessary.
In view of test time , this is compensated by performing binaural recordings.
In view of the complex multifactorial causes of delirium , multicomponent non-pharmacological risk factor approaches are the most effective strategy for prevention.
In view of the limited female reproductive lifespan , oocyte freezing can now offer women some protection against the decline in fertility with aging.
In view of these considerations , we hypothesized a mutual association between triiodothyronine and pro-inflammatory cytokines.
In view of these , it is argued that age-specific aspects should be considered in shift work planning.
In virtually all organisms , life expectancy is profoundly affected by caloric intake.
In virtuo exposure could be employed to improve the efficacy of CBT with exposure sessions in the treatment of late-life anxiety ?
In virtuo exposure has proven to be efficient to treat anxiety in working-age people.
In vitro aging ( IvA ) ( due to extended culture ) may also impair oocyte competence.
In-vitro aging platforms included replicative senescence and an energy restriction model in quiescence ( ERiQ ) , in which ATP was transiently reduced.
In vitro , a knock down CSB results in a reduction of transcription-induced deletions at CAG repeat tract.
In vitro analyses indicate that rs10816625 and rs13294895 have allele-specific effects on enhancer activity and suggest chromatin interactions with the KLF4 gene locus.
In vitro analyses of E145K-lamin A show severe defects in the assembly of protofilaments into higher order lamin structures.
In vitro analysis revealed that Cidea expression was regulated by oxidative stress and DNA methylation.
In vitro and in vivo studies also exhibited a close relationship between senescence and differentiation of primary oral keratinocytes and expression of inflammatory molecules.
In vitro and in vivo studies have demonstrated that renin-angiotensin system ( RAS ) blockade increases soluble Klotho levels.
In vitro and in vivo studies show that 12-15LO modulates tau metabolism specifically via the cdk5 kinase pathway.
In vitro angiogenesis ± rhVEGF-165 ( @number@ and @number@ ng / mL ) was measured in aortic segments in 3D-collagen.
In vitro approaches demonstrated that PRGF-Endoret treatment modulated astrocyte activation , reducing inflammatory responses , and promoted Aβ degradation.
In vitro assays like DPPH , FRAP , ABTS scavenging to evaluate radical quenching potential were performed.
In vitro BBB model is created with HUVEC / C6 ( rat glioma cells ) co-culture.
In vitro , BRAF overexpression resulted in growth arrest associated with DNA damage ( γH2AX expression ) .
In vitro , CA reduced dendritic spine loss in rat neurons exposed to oligomeric Aβ.
In vitro cultured Cap2 deficient keratinocytes showed reduced velocity and a delay in scratch closure.
In vitro , DA-CM clearly mitigated the decreased cell proliferation and delayed the senescence status in HDFs induced by ultraviolet B ( UVB ) .
In vitro , Dbl is known to activate Rho , Rac , and Cdc42 and to induce a transformed phenotype in murine fibroblasts.
In vitro , E4-expressing microglia exhibit higher innate immune reactivity after lipopolysaccharide treatment.
In vitro experiments of gain and loss of function suggest that down-regulation is a direct consequence of miR-128 up-regulation found in AD-related cells.
In vitro , FSH inhibited endometrial proliferation and promoted the apoptosis of primary cultured endometrial cells in a dose-dependent manner.
In vitro functional analysis revealed that the IFIH1 c.2465G > A mutation enhanced MDA5 function in interferon beta induction.
In vitro functional studies revealed that the c.1414delA ( p.Ile472Serfs 8 ) variant was associated with reduced mRNA expression of TBK1.
In vitro , GABA stimulated production and secretion of Klotho by human islet cells.
In vitro gastric coagulation was observed only for the casein protein supplements.
In vitro , IL-27 was ineffective on cancer cell proliferation or apoptosis , but fostered CXCL3 / GROγ / MIP2β expression.
In vitro incubations of phosphopeptides demonstrated that this process can occur spontaneously under physiological conditions.
In vitro , iPSC-CMs from these patients reproduced the histological features and autophagy failure of Danon disease.
In vitro migration / invasion assays after manipulation of the TR4 expression in PCa cells showed that TR4 promoted PCa cells migration / invasion.
In vitro , miR-125b regulates human lens epithelial cell apoptosis at least in part by directly targeting p53.
In vitro , @number@ types of senescence have been described.
In vitro , omega-3 rich oils improved membrane fluidity by @percent@ compared with the control cells.
In vitro reconstitution assay reveals that XIAP is directly ubiquitinated by TRIM32.
In vitro results were checked using primary HNSCC.
In vitro S100A9 forms neurotoxic linear and annular amyloids resembling Aβ protofilaments.
In vitro senescent A549 lung epithelial cells had elevated K10 and LR protein levels and were up to 5-fold more permissive for bacterial adhesion.
In vitro studies employed T lymphocytes from DC subjects with a hTERC mutation and age-matched controls.
In vitro studies in primary neurons demonstrated Aβ-induced type-1 IFN expression preceded that of other classical pro-inflammatory cytokines , IL1-β , and IL-6.
In vitro studies were conducted using rodent islets and clonal rat and human pancreatic β-cell lines ( BRIN-BD11 and @number@.1B4 respectively ) .
In vitro studies with HepG2 cells demonstrated that treatment with IL-1β significantly induced lipid accumulation in hepatocytes through the regulation of PPARα and SREBP1c.
In vitro study using human vascular endothelial cells further confirmed the increased mRNA and protein expressions of VEGFR2 but not VEGF-A by BPC @number@
In vitro , tau binds to both phosphorylated and nonphosphorylated tau.
In vitro testing of signaling pathways was performed under oscillatory and laminar wall shear stress conditions.
In vitro tests continue to be an indispensable method for the initial screening of dental materials.
In vitro , the 352Thr-371Val haplotype impaired SIM1 transcriptional activity by @percent@ ( P < @number@ ) .
In vitro , the effect of DA-CM on stress-induced premature senescence in HDFs was investigated by 5-ethynyl-2'-deoxyuridine ( EdU ) staining and β-galactosidase staining.
In vitro , we found that FPKc induced S180 tumor cells apoptosis and cell cycle arrest , possibly via the mitochondrial pathway.
In vitro , α-synuclein binds to phosphorylated Ser ( @number@ ) of Tau and stimulates PKA-catalyzed Tau phosphorylation at Ser ( @number@ ) .
In vivo administration of adenovirus producing Adipo suppressed plasma levels of GPI phospholipase D , the endogenous cleavage enzyme for GPI-anchored proteins.
In vivo analyses were performed for mechanical properties such as isokinetic performance , isometric torque , and power.
In vivo analysis of the fornix reveals the cone of uncertainty to be a predictor of memory function among older adults.
In vivo and in vitro MDA generations were similarly suppressed by polyphenol-rich beverages ( red wine and coffee ) consumed with the meal.
In vivo , aortic endothelial apoptosis was potently prevented in pioglitazone-treated animals ( hairpin oligonucleotide assay ) .
In vivo ARIH2 mRNA levels significantly decrease from midlife in vastus lateralis muscles and highly correlate with muscle degeneration.
In vivo Aβ deposition has been studied in relation to genotype , structural and functional brain changes , as well as alterations in biomarker levels.
In vivo blockade of LR signaling combined with iNKT stimulation resulted in superior anti-tumor protection.
In vivo bone densitometry , mechanical and histomorphometric analyses revealed a mild osteoporotic phenotype in the FLNA-null 5-month and aging groups.
In vivo brain imaging is a promising tool for the early detection of AD through visualization of abnormalities in brain structure , function and histopathology.
In vivo , CA treatment of hAPP-J20 mice improved learning and memory in the Morris water maze test.
In vivo confocal microscopy evaluated the limbal and central DC density , the DCs morphology and distribution.
In vivo data indicated that FPKc inhibited the solid tumor growth and prolonged the survival time of tumor-bearing mice.
In vivo detection of brain β-amyloid plaque density may increase diagnostic accuracy in cognitively impaired patients.
In vivo , DHTS potently inhibited xenograft tumor growth in a HuR-dependent model without systemic toxicity.
In vivo , EPO + IGF-I treatment prevented gp120-mediated neuronal loss , but did not alter microgliosis or astrocytosis.
In vivo experiments using IκBα mutant mice with continuous NF-κB activation demonstrate increased IGF2 LOI further confirming a central role for canonical NF-κB signaling.
In vivo experiments were used in human and Sprague-Dawley rat teeth obtained from young and adult individuals.
In vivo , gap-free enamel margins were reduced from initially 86-90% to 74-80% after @number@ years of clinical service ( p < 0.05 ) .
In vivo , HSCs expand significantly in the niche , but establishing protocols that result in HSC expansion ex vivo remains challenging.
In vivo imaging using the Pittsburgh compound B ( PiB ) ligand has facilitated studies linking Aβ , cognition , and dementia in DS.
In vivo , induction of IL-1β and OPN were delayed but prolonged in aged mice upon RSV infection compared to young.
In vivo inhibition of AKT activity result in reduced NF-κB activation.
In vivo measurement of BL thickness by IVCM could aid in clinical assessment and planned treatments of the anterior cornea.
In vivo measurements of R An infant's ability to perceive emotional facial expressions is critical for developing social skills.
In vivo measurements showed that the overexpression of PON1 significantly increases the fecal elimination of macrophage-derived cholesterol in PON1-Tg mice.
In vivo microdialysis studies demonstrated that Aβ clearance in brain interstitial fluid is impaired in neuronal Lrp1 knock-out mice.
In vivo models of diabetes corroborated epidemiological studies.
In vivo neuroimaging tools have begun to identify the brain systems and networks potentially responsible for reserve.
In vivo , neutralizing human tau in @number@ human tau transgenic models also reduced Aβ levels.
In vivo radiosensitivity was assessed by growth of human tumors xenografted into nude mice.
In vivo RCM and high-frequency ultrasounds were used to evaluate ECM and EDJ undulation modifications caused by aging.
In vivo RCM measurements indicated a decrease of EDJ undulation depth with age and ECM modifications in the upper part of dermis.
In vivo RCM studies indicated that the peptides improved the ECM structure vs. placebo.
In vivo reflectance confocal microscopy ( in vivo RCM ) and echography were also used.
In vivo , SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain.
In vivo , SIRT1 undergoes an extensive degradation in hepatocytes in obesity as a consequence of persistent activation of JNK1.
In vivo studies also determined that the CPP-conjugated liposomes were more effective in depigmentation and anti-wrinkle studies than typical liposomes.
In vivo studies also require significant resources and infrastructure , and require researchers to work all night.
In vivo studies on ten female subjects were evaluated by using non-invasive skin bioengineering techniques.
In vivo study showed that overexpression of miR-30c suppressed EMT , attenuated renal tubulointerstitial fibrosis and reduced proteinuria , serum creatinine , and BUN levels.
In vivo study , the QCZ NPs could cure inflammation and lesion which caused by E. coli.
In vivo , sunitinib treatment restored LC3-II , p62 , and endophilin B1 ( EndoB1 ) levels in doxycycline-induced Tat transgenic mice.
In vivo transplantation revealed that SkM-differentiated hDE-MSCs can efficiently incorporate into host SkM tissue in a mouse model of SkM injury.
In vivo tumor-bearing animal experiments further verified GCIS / ZnS@PLVs could achieve tumor-targeted MR / fluorescence dual-modal imaging.
In-vivo tumor inhibition and mice survival time were determined.
In vivo , wear phenomena are superimposing marginal quality aspects.
In vivo , we found that subcutaneously injected 10-fold concentrated DA-CM increased the expression of collagen types I and III.
In vivo , we studied the antifibrotic effects of BAY 41-2272 in mice overexpressing a constitutively active TGF-β1 receptor.
In Vojnosanitetskipregled , @number@ articles on the elderly and @number@ on children were registered ( p < @number@ ) .
Involuntary attention switching is suggested as the main factor driving these differences.
Involuntary episodic memories are memories of past events that come to mind with no preceding attempt of retrieval.
Involuntary episodic remembering may provide an adaptive compensation for reductions in strategic retrieval in later adulthood.
Involuntary orienting is traditionally measured with non-predictive peripheral cues and voluntary orienting with predictive central arrows.
In volunteers , men reacted faster than women and their reaction times slowed with age.
Involvement in leisure activities increased between the cohorts.
Involvement of phosphorylated mitogen-activated protein kinases and JNK signaling in regulation of these molecules was characterized by western blotting.
Involvement typically begins in the petrous apex and progresses laterally.
Involvement with computers , crossword puzzles , handicrafts , and formal education courses also were protective factors.
Involving them in SDM is an important way of promoting social health.
In voxel-based analyses , FDG-PET and MRI GM maps were compared between HC converters and HC non-converters.
In VSMC from these patients undergoing abdominal surgery , secretion of TGF-β1 was determined by ELISA of cell-conditioned media.
In vulnerable or frail patients , weekly or biweekly docetaxel regimens are acceptable treatment options.
In Wave @number@ mental health generally was worse at older ages , with women having more symptoms at younger ages than men.
In Wave @number@ the overall weighted mean CCFM score was @number@ ( SE @number@ ) .
In western blot , TNF-α-induced the expression of p53 and was inhibited from @number@ to @percent@ , by DTD serum in a concentration-dependent manner.
In Western countries , the total number of elderly patients with colorectal cancer is expected to increase in the future.
In Western Europe , vaccination of at-risk groups forms the cornerstone of influenza prevention.
In white matter , it was @number@ with an ICC of @number@
In white women , chronological age was significantly correlated with worsening skin wrinkles , but not with rigidity.
In white young adults only , higher genetic risk predicted increased risk of becoming obese during the study period.
In wholemount samples , its strong and stable fluorescence facilitated a semiquantitative evaluation of BrM-EC content over a large area.
In WI38 / hNaDC3 cells treated with the activators of SIRT1 , aging-related phenotypes induced by NaDC3 were obviously improved.
In Wilkie et al.
In women AFs are associated with weight and BMI.
In women , age was an effect modifier for education in the risk of obesity and smoking.
In women , ALA from vegetable oils also tended to be inversely linked to photoaging.
In women , all physical function measures were significantly associated with quality of life measures in unadjusted models ( p-values < 0.05 ) .
In women , ALM / Ht ( @number@ ) did not improve the model when subcutaneous fat was included.
In women , AMH declines with age and data suggest a relationship with remaining reproductive lifespan and age at menopause.
In women , a moderate level of physical activity was related to reduced fracture risk ( HR @number@ @number@ % CI @number@.33-0.99 ) .
In women and older age groups , IOP was less decreased than that of men and young age groups.
In women , an increase in glucose was associated with reduced Cdist ( β ± SEM = @number@ ± @number@ P = @number@ ) .
In women , Asians had @number@ SD lower porosity and @number@ SD higher trabecular density than Caucasians ( p < 0.01 ) .
In women , a significant correlation was only observed between forearm-ulna MT and TMM index.
In women attending urogynaecology clinics with pelvic floor symptoms the impact of most symptoms ( particularly sexual dysfunction ) become less bothersome with age.
In women , BMI-specific hand-grip strength cutoff values was not markedly more accurate than the overall cutoff value.
In women , breast cancer is one of the most common diseases and numerous women succumb to it.
In women , circulating testosterone concentration also gradually declines until menopause , after which a drastic reduction is found.
In women continuing PI / NNRTI , increased visceral adipose tissue correlated with increased PGI-M and PGE-M.
In women , DHEA improves sexual satisfaction , fertility and age-related vaginal atrophy.
In women , FFM was lower from age @number@
In women , however , each component of MetS with the exception of fasting glucose was not associated with renal function.
In women , INSL3 is a paracrine factor within the ovary and probably placenta , in which it may have a fetal gender-specific role.
In women , it was @number@ to @number@ times stronger.
In women , no association between Lp ( a ) and CHD risk was observed.
In women , no associations were found between VO2peak and brain volumes.
In women older than @number@ years , more immediate evaluation and treatment are warranted.
In women older than @number@ years , more immediate evaluation and treatment are warranted.
In women , periorbital lines were the first visible wrinkles , in contrast to the forehead lines in men.
In women , perirenal fat volume and thickness showed a negative correlation with SC-fat thickness and no correlation with waist circumference.
In women , poor hearing sensitivity was associated with high body mass index , high resting heart rate , fast PWV , and low AAI.
In women , rates ranged between @number@ and @number@ per @number@ person-years.
In women , sexual function , hormones and aging are inextricably related.
In women the association between osteoporosis and carotid plaques likely reflects hormonal deprivation , whereas that between osteoporosis and PAD seems multifactorial in origin.
In women the incidence of colorectal and lung cancer stabilized after an initial increase.
In women , the menopause transition also affects test performance and can confound estimates of underlying decline.
In women , the most important symptoms of sexual dysfunction are lack of emotional wellbeing and a sense of intimacy during sexual intercourse.
In women , there was no pattern of association and all confidence intervals crossed @number@
In women , there was no statistically significant correlation between jaw opening force and any of the measurement items.
In women , the stable period was observed until approximately @number@ years.
In women , thigh SAT area was positively associated with mobility limitation risk , whereas VAT density was inversely associated.
In women we also found an association between increasing leptin concentration over time and rapid decline of renal function.
In women who became postmenopausal by year @number@ fat and protein intakes decreased across the menopausal transition ( @number@.05 > P < 0.01 ) .
In women with a high total physical activity score ( > 174 min / day ) , WHR was lower in the lowest IGF-I quartiles.
In yeast , the retrograde response genes ( RTG ) convey these stress responses to the nucleus to change the gene expression adaptively.
In young adult European Americans ( FAMUSS ) , H1 was associated with higher fasting glucose levels in females.
In young adult humans and animals this process is homeostatic with no net gain or loss of bone mass.
In young adult rats , it is neuroprotective ; chronic treatment with 17β-estradiol during aging leads to worsened ischemic brain injury in aged female rats.
In young adults , adenosine triphosphate ( ATP ) has been shown to blunt sympathetic vasoconstrictor responsiveness similar to exercise.
In young adults , high-energy and hyperextension injury was the most frequent cause of upper cervical spine injury.
In young adults , theta-band ( 4-8 Hz ) oscillatory power over medial frontal and anterior frontal cortex predicted learning after errors.
In young adults ( YA ) , a relationship between peak VO2 and cognition was not evident.
In young but not in old adolescents , higher cortisol output was related to stronger deactivation of clusters in the anterior and posterior cingulate cortex.
In younger adults , it had no relation to life satisfaction and depressive symptoms.
In younger adults , suicide has been linked to abnormal decision-making ability.
In younger adults , we observed an early posterior negativity ( 90-120 ms ) that predicted performance accuracy.
In younger control subjects , the values were @number@ ± @number@ µm , @number@ ± @number@ µm , and @number@ ± @number@
In younger individuals , vertebral artery calcifications were more likely than calcification in anterior brain arteries , but this difference attenuated with age.
In younger participants , the TBUT recovered faster than in older patients.
In younger subjects , the late alpha ERS occurred between @number@ and @number@ ms and its amplitude was significantly higher compared with elders.
In younger subjects , TL was significantly shorter in those with high aPWV vs. those with low aPWV ( P = @number@ ) .
In young men there is an inverse relationship between MSNA and cardiac output where high MSNA is compensated for by low cardiac output.
In young mice , Sod2 deficiency accelerated epidermal thinning in response to the tumor promoter , phenocopying the reduced regeneration of older Sod2-deficient skin.
In young mutants , similar to controls , germ cell development was normal.
In young patients , aortic dissection was more frequently caused by a genetically determined disorder in the elastic skeleton in obvious substitutive sclerosis.
In young patients , sRAGE showed no correlation with the number of retrieved oocytes , fertilized oocytes , high-quality embryos or achievement of clinical pregnancy.
In young patients with normal baseline investigations , screening investigations every @number@ or @number@ years seem to be sufficient.
In young people , the influence of high SNA on BP is balanced by lower cardiac output and less adrenergic vasoconstrictor responsiveness.
In young rats , the nocturnal pineal gland MLT content exceeded daytime levels by 19-fold compared to a sevenfold increase in old mice.
In zebrafish , isonitramine alleviated the streptozotocin ( STZ ) -induced postprandial hyperglycemia and protected the pancreatic damages against alloxan-induced oxidative stress in vivo.
In β-myosin heavy chain mutations , transgenic mice and humans have similar progression in morphologic and functional abnormalities.
Iodine deficiency is known to cause brain structural alterations likely to affect cognition.
Ion conduction mechanisms of ion channels are a long-standing conundrum.
Ionic fluxes changes play a key role in several patho-physiological cellular processes , but their relation to human aging is largely unexplored.
Ionizing radiation ( IR ) is a well-known human carcinogen.
Ionizing radiation is one of the most potent genotoxic stimuli and causes various kinds of DNA damage.
Ions were detected in selected reaction monitoring ( SRM ) mode , and transition m / z @number@ → @number@ was used for quantitation.
IOP was evaluated using a noncontact tonometer.
IOP was found to increase with total cholesterol , TG , BMI , and to decrease with only age regardless of sex.
IORF / OF ratio increased with age , and , unlike fat volume , there was no decline after @number@ years of age.
IPA tends to be a multigenerational problem that older women are reluctant to discuss.
IPF is a disease of aging that most commonly affects human subjects older than @number@ years of age.
IPF is a fibrotic disease and , most frequently found in an aged population.
IPF is predominantly a disease of older adults , and the processes underlying normal aging might significantly influence the development of IPF.
IPL achieves similar clinical efficacy.
IPL irradiation was able to upregulate expression of collagen ( types I and III ) at the mRNA and protein level.
IPL treatment is also much more efficient.
IPL was faster , but nonablative @number@ , 064-nm Q-switched laser was more effective in improving skin tone and macula.
IPOD is perivacuolar and predominantly sequesters amyloidogenic proteins.
I propose an alternative approach that avoids the disability objection , and consider its implications for specific proposals for age-based rationing of health care.
I provide a review of these dynamics and illustrate associated vulnerabilities in nonhuman species.
IPSC-derived RPE cells were plated onto RPE-derived ECM under untreated or nitrite-modified conditions.
IPW estimation involves weights for the exposure mechanism , dropout , and mortality ; AIPW estimation additionally involves estimating data-generating models via regression.
IQ data were available from mean age @number@ years.
IQ increases were associated with cessation of antiepileptic medication and changes in MRI-derived gray matter volume.
IQ scores were available from childhood.
IRB approval was granted at Hannover Medical School , Germany on @date@ .
IRB No. : DMR94-IRB-179.
IRE1 is an ER-located kinase and endoribonuclease that operates as a major stress transducer , mediating both adaptive and proapoptotic programs under ER stress.
IRE1 signaling controls the expression of the transcription factor XBP1 , in addition to degrade several RNAs.
I replicate the test with data from England and Wales.
I review telomerase knockout and overexpression studies and find little support that telomeres cause aging.
IR in diagnosis and cancer radiotherapy is well-known.
Iris as a biometric identifier is assumed to be stable over a period of time.
Irisin , a newly described hormone released from skeletal muscles after exercise , may induce CR-like effects by increasing adipose tissue energy expenditure.
Irisin is a hormone-like myokine produced in abundance by skeletal muscle in response to exercise , both in mice and humans.
IR is involved in cardiovascular and metabolic diseases , pathologies which are highly prevalent in older patients.
IR is related to greater amyloid burden post-mortem and increased deposition within areas affected by early AD.
Iron accumulates concentrically in a subset of chronic inactive lesions suggesting that not all iron rims around MS lesions equate with smoldering plaques.
Iron- and neuromelanin-sensitive MRI detect qualitative changes in the substantia nigra.
Iron , calorie or cholesterol intake were not directly associated with brain IDs.
Iron can catalyze damaging free radical reactions.
Iron chelators can reduce oxidative stress by the removal of iron from target tissues.
Iron deficiency anaemia is prevalent in older age , particularly after the age of @number@
Iron-deficiency anemia in infancy is associated with impaired neurodevelopment.
Iron deficiency causes anaemia , whereas excessive iron increases cancer risk , presumably by free radical generation.
Iron deficiency is frequent in elderly population and is responsable for numerous clinical situations.
Iron deficiency seems to be the main cause of anemia , and chronic disease the second cause of anemia.
Ironically , at high doses DNA damaging agents are also used to treat cancer.
Ironically , this is often misunderstood as a sort of programmed aging.
Ironically , though , many people seem to be living longer than expected.
Iron is an essential co-factor for many enzymes that catalyze electron transfer reactions.
Iron is a trace metal , key for the development of living organisms.
Iron is dangerous by catalyzing free radical formation and by serving as an essential nutrient for microbial and neoplasmic cell invaders.
Iron is necessary for proper function of both the innate and adaptive immune system.
Iron is universally abundant and no life can exist without it.
Iron-mediated cellular destruction is mediated primarily via reactive oxygen or / and nitrogen species induced oxidative stress.
Iron mediates electron transfer as an essential component of e.g. myeloperoxidase , hemoglobin , cytochrome C and ribonucleotide reductase.
Iron overload in neurons via the ferroportin block may play a role in Alzheimer's disease.
Iron overload may contribute to the risk of Alzheimer's disease ( AD ) .
Iron's carcinogenicity has been documented in animal experiments.
Iron status and immune response become impaired in situations that involve chronic inflammation , such as obesity or aging.
Iron status indices were measured.
Iron , TIBC , transferrin , C-reactive protein and complete blood count were assayed using standard laboratory methods.
Irradiances and treatment durations varied in all treatment groups.
Irradiated Balb / c mice were the least similar to humans.
Irradiated , vitamin E-diffused , and gamma sterilised UHMWPEs have been in clinical use in hips since @number@ and in knees since @number@
Irradiation shifted metabolic features to those seen in older units.
Irradiation time should be at least @number@ s to yield favorable mechanical properties.
Irregular function of platelets and enhanced interaction with leukocytes and endothelial cells can contribute to pathogenesis of atherosclerotic and thrombotic events.
Irregularities proved minor and easily correctable ; no intravascular complications were noted in this series of patients.
Irregular particulate matter was present in RES but BEL and JUV were largely particle free.
Irreproducibility in odor identification appears to be a non-disease-specific , general feature of olfactory dysfunction that is accelerated or accentuated in neurodegenerative disease.
Irrespective of A2E concentration , the loss of cell viability was maximal for wavelengths from @number@ to @number@ nm.
Irrespective of dementia status , persons with more diseases had significantly worse baseline daily functioning.
Irrespective of sex , the ratio of BPA-to-creatinine level was not predictive of indices of glucose homeostasis.
Irrespective of the age of the donor hepatocytes , large cell clusters appeared in juvenile , but only small clusters in senescent host livers.
Irrespective of the cognitive trajectory , increased social engagement was associated with a decreased mortality risk.
Irreversible morphological lesions appeared during week @number@ where discocytes began to transform into transient echinocytes and finally spherocytes.
Irritable bowel syndrome ( IBS ) is one of the most commonly encountered functional gastrointestinal disorders in the elderly.
Irritant contact dermatitis studies are more consistent , with less reactivity ( to irritants ) in older compared with younger skin.
ISAI consisted of 30- to 60-minute sessions for up to @number@ consecutive days.
Is a slip in memory an expected outcome for a too-busy person or a warning of something else ?
Isavuconazole is a novel broad-spectrum triazole antifungal agent.
Isavuconazole ( ISAV ) is a new mucormycosis treatment.
Ischaemic heart disease and the heart failure that often results , remain the leading causes of death and disability in Europe and worldwide.
Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions.
Ischemic changes , homozygous mutation , and diabetes mellitus as well as aging might have contributed to the observed progressive dysphagia.
Ischemic heart disease is the leading cause of mortality worldwide.
Ischemic heart disease was the main underlying cause for HF in both cohorts.
Ischemic infarction was the prevalent stroke subtype ( @percent@ ) .
Ischemic Injury Scale ( IIS ) operationalized CVD.
Ischemic small vessel disease ( SVD ) may lead to cognitive impairment , but cognitive deficits with a given burden of SVD vary significantly.
Ischemic stroke accounts for approximately @percent@ of all stroke cases in China and will significantly increase the health burden because of the aging population.
Ischemic stroke causes the largest loss of QALY.
Ischemic stroke is a leading cause of death and disability in the United States.
Ischemic stroke is a leading cause of death worldwide.
Ischemic stroke is associated with aging.
Ischemic stroke is emerging as a major health problem for elderly women.
Ischemic stroke is the most common type of stroke.
Ischemic stroke occurred in @number@ patients ( @percent@ ) , and no patient developed hemorrhagic stroke.
Ischemic stroke promotes neurogenesis by several growth factors including FGF-2 , IGF-1 , BDNF , VEGF and chemokines including SDF-1 , MCP-1.
Ischemic strokes were then classified according to a modified TOAST classification.
Ischemic vascular events were more common than recurrent ICHs ( @number@ per @number@ patient-years vs. @number@ per @number@ patient-years ; P = @number@ ) .
ISEL scores were significantly but modestly negatively correlated with grief severity.
Is estimated to affect @number@ to @percent@ of individuals with a history of polio in childhood.
I show the implications of this critique for the prudential life span account and for the special case of age-group justice.
IS is the major risk factor for VaD and AD.
Is it possible that the pronounced demographic changes that have occurred in China have affected influenza transmission ?
Is it possible to age better together intentionally ?
Is it simply a question of inner strength ?
Island Health is addressing this challenge by transforming its traditional education model into an innovative , evidence-based learning and performance support approach.
Islets and fat are important organs involved in energy metabolism.
Islets of type @number@ diabetes patients have been shown to have decreased hypoxia-inducible factor ( HIF ) -1α / β expression.
ISNAs are not benign signs.
Isoaspartate formation is a common type of protein damage normally kept in check by the repair enzyme protein-L-isoaspartyl methyltransferase ( PIMT ) .
Isobaric tag for relative and absolute quantification ( iTRAQ ) was used to identify additional proteins with a potential effect on porcine retinal survival.
Isobaric tags for relative and absolute quantification and liquid chromatography tandem mass spectrometry were used to determine differential protein abundances between the nutrient restriction conditions.
Isocapnic buffering was particularly small in the older untrained volunteers.
Isoflavones have been reported to protect against Aβ-induced neurotoxicity in cultured cell systems , the molecular mechanisms remain unclear.
Isoflavones may hold promise as a treatment option for preventative strategies targeting amyloid formation in Alzheimer's disease.
Isoforms of subunits COX6A and COX7A expressed in heart and skeletal muscle are different from isoforms expressed in the liver , kidney and brain.
ISO for photoaging treatment was reported in non-controlled trials as alternative to RA , which causes skin irritation.
Isokinetic quadriceps strength was measured semiannually over @number@ years.
Isokinetic quadriceps work and fatigue index was determined over @number@ repetitions and compared with isometric quadriceps maximum torque.
Isokinetic strength was also significantly greater in the CT group than in the AT group ( p < @number@ ) .
Isokinetic truncal flexion and extension power were measured.
Isolated alveolar epithelial cells were examined for expression of inflammatory mediators , and chemotaxis assays were used to assess their importance.
Isolated atrial amyloidosis ( IAA ) is a common localized form of amyloid deposition within the atria of the aging heart.
Isolated exosomes were analyzed by western blotting.
Isolated mitral and combined procedures have the highest complications and costs.
Isolated omics analyses usually provide Big Data requiring large data storage , advanced computational resources and complex bioinformatics tools.
Isolated PCO in an ovulatory woman is not an indication for metabolic evaluation.
Isolated populations have advantages for genetic studies of longevity from decreased haplotype diversity and long-range linkage disequilibrium.
Isolated systolic hypertension and widened pulse pressure appear to be more important than diastolic hypertension.
Isolated systolic hypertension is a major health burden that is expanding with the aging of our population.
Isolation of S. typhimurium-containing phagosomes have been widely used to study how S. typhimurium infection alters the process of phagosome maturation to prevent bacterial degradation.
Isomerization levels differ significantly between the WS and the WI fractions from sheep , pig , and cow eye lenses.
Isometric exercise significantly increased both positive and negative affect ratings.
Isometric exercises reduced temporal summation illustrating the potential for exercise as a rehabilitation procedure also targeting the central mechanisms.
Isometric handgrip ( IHG ) remains a well-studied cardiovascular and autonomic stimulus , however the effects of rhythmic IHG protocols remain largely unknown.
Isometric muscle strength at the ankle , knee and hip joints was assessed using a dynamometer.
Isometric skeletal muscle strength was assessed by measuring knee extension strength.
Isometric twitch properties and MVCs were tested at baseline and during and following the fatigue task.
Isoperformance curves were developed from the relationship between BMI and handgrip strength for men and women with the aforementioned clinical phenotype classification criteria.
Isotopic uptake studies in cells demonstrated that BCRP transports allopurinol and genetic variants in ABCG2 affect this transport.
I-squared indicator and Q test were performed to assess heterogeneity.
I-squared indicator and Q test were performed to assess heterogeneity.
ISRCTN31857696.
ISR gives rise to patient stress , nervousness , and a decrease in quality of life ( QoL ) .
Issues and future directions are also discussed.
Issues are discussed in relation to Maori and Pacific development and the importance of prevention and early detection of chronic health conditions.
Issues frequently arise concerning the cognitive and emotional ability of older individuals to make certain legally significant decisions.
Issues involving people with disabilities cut across the overarching domains of education , training , research , and service.
Issues of long-term outcome in elderly hypertensive patients with metabolic syndrome taking into account the peculiarities of left ventricular geometry are highlighted.
Issues regarding the interpretation and reporting of findings are also discussed.
Issues related to the management of these symptoms in the aging population are also considered.
Issues related with molecular testing and Genetic Counseling , as well as recent progresses and perspectives on genetic therapy , are also addressed.
Is the developing bilingual brain fundamentally similar to the monolingual brain ( e.g. , neural resources supporting language and cognition ) ?
Is the functional influence of Selfreference still present when the individual's memory and identity are impaired ?
Is their anti-atherosclerotic effect restricted to primary prevention or can it alter the prognosis of existing cardiovascular and cerebrovascular diseases ?
Is there an accumulation of stress in later working life ?
Is there any basis for these questionings ?
Is there any benefit of using one approach compared to the other ?
Is there a possibility of future intergenerational political conflict over taxes and expenditures for the major old-age benefit programs ?
Is there a reversible stage of brain microangiopathy ?
Is this effect dependent on p21s ability to inhibit p53 ?
Is this enough to bring passion in the younger generation ?
Is this new anti-ageing intervention pointing a way towards new treatments for age-related diseases ?
Is timing of occurrence a random event or is it indicative of different pathophysiological pathways leading to different phenotypes across the age spectrum ?
I studied patients who had received end-of-life care at our clinic and investigated integrated community care based on these experiences.
I suggest that these transformations , albeit subtle , lead to reformulation of the fabric of the family.
I suggest that this effect is due to observer failure to ignore smile-associated wrinkles , mainly along the region of the eyes.
It acts via G protein-coupled receptors expressed in various areas of the central nervous system and in peripheral tissues.
It affects surface lipids and increases skin regeneration ability.
It aims at describing the basic areas of cooperation and introducing its major players.
It aims to develop a demographic and psychographic profile of medical travelers and identify their underlying motives to seek medical care overseas.
It aims to reproduce human intelligence in its learning capacity , knowledge storage and computation.
Italians were less likely to use permanent residential care.
It allows the entry and exit of numerous ions and metabolites between the cytosol and the mitochondrion.
It allows the regulation of multiple cellular processes including protein and lipid synthesis , ribosome biogenesis , autophagy and metabolic processes.
It already showed a good specificity and sensitivity in discriminating normal controls from probable Alzheimer's disease patients.
It also accelerates arterial aging , which plays a role in chronic hypertension.
It also addresses moral-ethical dilemmas that will likely affect mental health nurses caring for this population.
It also aimed at investigating the mediating role of emotion regulation on the relationship between age and emotions.
It also attenuated Aβ-induced impairment of synaptic exocytosis.
It also briefly outlines recent studies on the relationship between bone and fat in the marrow as well as the periphery.
It also coincides with the devolution of welfare programs.
It also comprised two open-ended questions requiring qualitative responses.
It also contributes valuable experiences from field work and interactions with older adults and their families.
It also controls temperature and the inflammatory response.
It also correlates with depression and dementia , and can contribute to considerable caregiver stress and burnout.
It also demonstrates that a 5-year difference in smoking history can cause noticeable differences in facial aging in twins.
It also describes the proportion of variance in residents ' self-care disability that is explained by residents ' geriatric syndromes versus long-term care home characteristics.
It also describes tools-biological , chemical , and physical-that are available to researchers studying the worm.
It also discusses how a VTE forms , the signs and symptoms , and the methods used to diagnose and treat VTE.
It also evaluated the association between obesity and socio-economic status.
It also examined different manifestations of the controversy that arises in scope of practice debates.
It also examines associations between network types and well-being indicators : loneliness , anxiety , and happiness.
It also examines the relationship between use of MBT and depression severity.
It also exhibits the lowest stiffness value , being suitable for uses that require maximum comfort.
It also explores approaches based on the hierarchy of risk controls to reduce fatalities and injuries in this cohort.
It also explores the mechanism ( s ) by which food may enhance memory.
It also finds that some motivations are associated with lower risk of problem gambling.
It also had a relatively long effect on improving skin laxity ; however , it had only a limited ability to improve rhytides and dyschromia.
It also has a good tolerability profile , a pharmacokinetic profile unaffected by age and a low propensity for drug interactions.
It also has been known that , during life , organisms accumulate oxidative damage that negatively affects cell metabolism.
It also has other functions in the adult , for example in bone metabolism , extending its role as a largely gender-specific hormone.
It also has other properties , supporting its use for non-acne indications.
It also has the potential to reduce risk of excessive bleeding in lung transplantation.
It also has to delay the process of aging.
It also highlights areas that are in need of more research.
It also highlights the importance of linking patients to nonmedical programs and services in the community.
It also highlights the mechanisms of diabetes-induced brain injury.
It also highlights the relevance of interventions at the level of the physical and / or social environments surrounding elders in pain.
It also highlights the relevance of using the bio-tribometer as an exploratory tool for the measurement of skin elasticity in vitro.
It also highlights the role of diminished muscle mass and strength in cardiometabolic disease mortality.
It also identified PIM use as a predictor for mortality in this group of individuals.
It also illustrates the need for future studies to develop better social care policies for increasing numbers of single caregivers and single elders.
It also improved lower urinary tract symptoms and prostate-related quality of life.
It also improves bone mineral density at numerous sites and both increases markers of bone formation and decreases markers of bone resorption.
It also includes comprehensive cardiovascular assessment , blood biochemistry , genetics and proteomics.
It also includes how people become closer to each other in a dialogue , involving verbal or bodily communication.
It also inhibited proinflammatory cytokine expression , allostimulatory ability upregulation , mitogen-activated protein ( MAP ) kinases , and NF-κB activation in AGE-albumin-stimulated DCs.
It also introduces similarly novel interventions currently under investigation as alternative means of accelerating exercise-induced cerebrovascular adaptation.
It also investigated the adaptability of mitochondria to @number@ weeks of HIT in older adults.
It also led to the loss of @number@ primary amino groups , which was accompanied by changes in protein mobility during native polyacrylamide gel electrophoresis.
It also lessens with advancing age.
It also mediates basal proton leak and regulates the mitochondrial permeability transition pore.
It also objectively correlates overall BMD with the known higher frequency of C-2 fractures in older patients.
It also occurs as a consequence of disuse and an age-related loss of muscle mass and strength ( sarcopenia ) .
It also outlines mitochondria-targeted therapeutics in neurodegenerative diseases.
It also partly blocks binding of semaphorin 3A to PNNs and attenuates PNN formation.
It also plays an important role in development and adult tissue homeostasis of different tissues , especially the central nervous system.
It also predicts adverse events in later life.
It also presents clinical guidelines on the treatment of glabellar lines , the frontalis muscle , peri-orbital lines , gummy smile and masseter muscle hypertrophy.
It also prevents the effects of metabolic disorders.
It also promoted proliferation of these cells.
It also promotes an evil cycle to further increase Beta-amyloid accumulation and exaggerates brain inflammation , possibly even the basal forebrain cholinergic degeneration.
It also provides preclinical evidence supporting recently described decreases in AD incidence.
It also provides the impetus for isolating mosquito genes that determine EIP.
It also provides useful functions for data analysis and visualization.
It also reflected a desire to safeguard autonomy in the face of pain in older age.
It also regulates the timing of the erectile process as a function of sexual desire , coordinating penile erection with sex.
It also remains to be determined how this parameter contributes to patellar instability in the growing knee joint.
It also remains to be determined if the interaction of ACE genotypes with some other genetic variants exerts a potential effect on longevity.
It also remains unclear whether such state or trait alterations may be evident at any given time-point , or whether they progress over time.
It also reports on interventions that may address these issues and explicitly acknowledges the lack of evidence-based interventions available to healthcare practitioners.
It also reverses bladder damage following ischemia / reperfusion.
It also serves as a central source of regulatory and practice information for administrators and providers.
It also showed to have good sensitivity and specificity for identifying more severe MCI.
It also shows potential in predicting a negative prognosis in those with MCI.
It also shows promise in enhancing their socialization skills.
It also shows the usefulness to learn from policy design and implementation of LTC policy in other countries , within and outside the EU.
It also shrank HTLV-1-associated solid tumors in an infected-cell-engrafted mouse model.
It also significantly blocked UVB-induced ROS generation in fibroblasts.
It also stimulates the mitochondrial apoptotic pathway and inhibits autophagy in a manner.
It also suggests a potential for policy interventions supporting individuals ' opportunities for successful aging.
It also suggests the implementation of knowledge translation strategies to assist in disseminating and integrating existing successful programs across the wider health system.
It also tests whether adding other measures to HARP improves its diagnostic accuracy.
It also underlines that adopting a gender and context sensitive approach into ageism opens up promising avenues for further conceptual development.
It also validated history and comprehensive geriatric assessment as reliable instruments to identify these subjects.
It analyzes changes driven by this law , especially in their impacts on elder women.
It answers some challenging questions.
It appeared that CMV infection did not affect thymic output but reduced RTL of CD8 + T cells in ESRD patients.
It appeared that @number@ Abs recognized hCGβ- , @number@ hCGα- , and @number@ αβ-heterodimer-specific epitopes.
It appears that a common feature of these conditions is impaired insulin signaling , affecting the brain as well as peripheral target tissues.
It appears that both employers and employees , young and old , view hard skills as far more important than soft skills.
It appears that older adults experience anxious types of attachment less frequently than younger adults.
It appears that the control of hypertension is not credited with the expected benefit for slowing the decline of renal function.
It appears that the effect of creatine supplementation is more beneficial in larger muscles and less effective in smaller muscles , however there are exceptions.
It appears that these fundamental questions warrant serious attention if the scientific nature of SD is to be eventually understood.
It appears that , with the exception of egg-donation , ART has no answer yet to age-related decline of female fertility.
It appears to be activated ETA and NADPH ( nicotinamide adenine dinucleotide phosphate ) oxidase in the vasculature.
It ascertains that adverse events occurring early in therapy are recorded.
It assessed clinical , general autopsy data and neuropathology including immunohistochemistry.
It assesses the extent to which those changes can alter the traditional model of care.
It , as well as its metabolites , is differentially effective in scavenging a variety of reactive oxygen and reactive nitrogen species.
It attenuates T helper @number@ allergic inflammation , and reduces eosinophilia and airway hyperreactivity.
It became a matter of federal statute in @number@ and has been adopted by most U.S. prison jurisdictions.
It becomes clinically relevant from @number@ years onwards , especially during intercurrent and neurodegenerative disease , oncological treatments , or after trauma.
It becomes crucial to define the right orientation of the associations between diabetes and cancer in order to identify the modifiable pathogenic mechanisms.
It began with puzzlement about and the flaring of research on the decline of wildlife , particularly avian species.
It begins with the evolutionary theories , explores the molecular-cellular mechanisms , and presents the perspective of the systemic theories.
It belongs to Neurodegeneration with Brain Iron Accumulation , a group of disorders where iron dysregulation is tightly associated with neurodegeneration.
It called for distinct populations to be included within national plans , including adults with intellectual disability ( ID ) .
It can affect food pattern and the risk of malnutrition and mortality of elderly persons.
It can also assess balance by measuring sway of the center of pressure.
It can also be applied to enhance eyebrows.
It can also be argued that these performance profiles mirror and provide an insight into the trajectory of the physiology of the human ageing process.
It can also help in ruling out reversible conditions that may have similar presentation of symptoms typical for Alzheimer's disease and related dementias.
It can also lead to endothelial and vascular dysfunction , accelerate the formation of atherosclerosis and increase the morbidity of cardio-vascular disease.
It can also lead to increased arterial stiffness , which is an accepted cause of increased arterial pulse wave velocity ( APWV ) .
It can also provide the medical unit to create data mold and a body health counselor when services in the society.
It can arise in one eye or both.
It can be applied at any age in order to maintain strong bones and reduce the risk of fracture.
It can be appreciated that such a sensitive biochemical detection system could confer diagnostic benefit in a clinical setting.
It can be argued that at least some of these changes could arise from astrocyte dysfunction.
It can be argued , that still uncovered mechanisms modify A-FABP behavior in elderly people , especially its association with multifactorial diseases.
It can be challenging for the development of new antiarrhythmic drugs.
It can be concluded that ginkgo aglucone flavone have acceleration on immune system function.
It can be concluded that increased antagonist muscle co-activation in elderly persons occurs in an early phase , already before the start of the movement.
It can be concluded that near visual acuity varies highly between individuals and decreases during the lifetime.
It can be concluded that PEP had positive effects on happiness among older adults.
It can be concluded that religiousness did not affect depressive mood or anxiety in the last week of life in the current sample.
It can be congenital or acquired.
It can be converted into androgens and estrogens by peripheral tissues.
It can be expected that inhibition of glycation may prolong the lifespan.
It can be identified by a multi-domain assessment of function.
It can be present in all age groups.
It can be proposed that changes in the content of angiomotin and endostatin yield a negative impact on angiogenesis in human skin during aging.
It can be speculated that this shift towards memory spines contributes to enhanced retention of remote memories typically seen in the elderly.
It can be subdivided into two broad categories , small cell lung cancer and non-small-cell lung cancer , the latter is the most common type.
It can be used in the assessment and monitoring of straw drinking in acquired disorders of swallowing.
It can be useful to understand the roles of those proteins in the testis.
It can cause many psychological , behavioral , biological , economic and social effects.
It can guide people to improve habitus through supports and establish important basis for new area development of folium ginkgo extract.
It can mildly to moderately improve the global photoaging.
It can offer a comprehensive geriatric evaluation and be a key element in decreasing postoperative morbidity and mortality in this unique population group.
It can only be diagnosed on the basis of both suggestive clinical features and clear biochemical evidence of testosterone deficiency.
It can penetrate to deep dermis due to its longer wavelength.
It can prevent the premature destruction of bone and promote its recovery through mechanisms of melatonin-related receptors and receptors of independent action.
It can reduce inflammation that increases with age and accompanies almost all age-related diseases.
It can represented human aging and disease.
It can suggest that dox-induced SIPS does not accelerate the mineralization of vessels.
It can testify about decreasing of attention and memory reserves and to promote disorder of the higher mental functions.
It captures the body size-biased extinction pattern in the late Pleistocene and precisely predicts the percentage of unexpectedly persisting large mammals and extinct small ones.
It carries a prominent role in determination of lifespan.
It causes alterations in the dermal connective tissue and gene expression , inflammation , photoaging , and DNA damage.
It causes conversational problems , whose prevention or solving can be influenced by the physician's own action.
It causes substantial human morbidity resulting in hundreds of thousands of deaths each year.
It centers on the question of how surveys respond to the challenge of diagnosing dementia.
It combats reactive oxygen species ( ROS ) known to be responsible for a variety of human pathological conditions.
It combines unbiased stereology with immunohistochemistry and immunofluorescence , making use of advanced graphics computing for three-dimensional ( 3D ) volume reconstructions.
It comprises only workers who were first employed between @number@ and @number@ and contains information on annual exposures to radon progeny.
It concerned the MAD , aLDFA , aMPTA and angle between the mechanical limb axis and anatomic femoral axis.
It concludes that major medical research organizations cannot afford to ignore programmed aging concepts in assigning research resources and directions.
It concludes that there is little evidence for the ' baby boomers ' as a strategic or distinctive generation.
It considers adverse drug reactions in the elderly and discusses prescribing for the older dental patient.
It considers the importance of the multidisciplinary team in providing an adequate service to the patient and his / her family.
It consisted of warm-up exercises , muscle strengthening , stretching , balancing , and self-administered massage to acupressure points.
It consistently contained fewer elastic and smooth muscle fibers than other levels.
It consists of actions to teach patients to improve and learn bladder control.
It consists of plastoquinone and decyltriphenylphosphonium ( a penetrating cation responsible for electrophoretic accumulation of SkQ1 in mitochondria ) .
It consists of two sections , one centered on disability and health among home-dwellers and the other on patients living in an institution.
It consists today of more than @number@ proteins which must work together like clockwork to distinguish friend from foe.
It contained questions about the provision of services for persons with dementia.
It contains a leucine-rich repeat ( LRR ) structure and easily binds with other molecules.
It contributes to ageing , disease and activity of cytototoxic chemotherapeutic agents.
It converts reversible arrest to irreversible senescence.
It correlated significantly with the original BBS , and had moderate correlations with static and dynamic aspects of balance ( p < 0.001 ) .
It could affect health promotion , policy and education for older adults in Korea.
It could also be due to an inflammatory persistent or be influenced by genetic factors.
It could be demonstrated that premature skin ageing was less in people with a high level of antioxidants in their tissue.
It could be demonstrated that the carotenoid concentration of the skin reflects the lifestyle of individuals.
It could be hypothesized that slower motor responsiveness is the cause of the global cognitive profile of these patients.
It could benefit to sustainable UHC , and therefore , it could ensure patients ' access to essential medicines.
It could be one of the independent predictors for PMI in stable CAD patients.
It could be particularly important for ESKD-related malignancies like native kidney tumors or thyroid cancers.
It could be recommended for diabetic patients with at least one more risk factors and for diabetic patients above @number@ years of age.
It could be shown that robust and valid BC-TEOAEs can be elicited using a nonlinear stimulation protocol.
It could be used to screen for the side effects of steroids.
It could facilitate the work of public health authorities , researchers , and physicians.
It could regulate cell survival and has been shown to be a protective factor in heart function.
It could serve as an efficient tool for stratifying older adults into different risk groups for planning care management programs.
It currently is clear that certain areas of the facial skeleton undergo resorption with aging.
It deals with three non-verbal sorting principles , individually and in pairs.
It decreased the expression of lipogenesis genes , but increased the expression of fatty acid oxidation genes.
It decreases expression of oncogens and interferes with the action of mutagens and clastogens at the genetic level.
It defines high glucose levels below the diabetes \ "cut-offs. \ "
It defines points related to functioning and health that are relevant when evaluating this population , as well as when reevaluating it and monitoring changes.
It demonstrated minimal floor and ceiling effects , which is an improvement over most individual cognitive tests.
It demonstrates special species-nonspecific form of weak external signals negative effect to cells life expectancy reduction caused by program damage of cells populations.
It demonstrates that ageing affects hHF keratinocyte CFE.
It describes the current evidence for each of these aspects and notes the paucity of data validating Leventhal's model in this regard.
It describes the methodological , practical , and philosophical challenges and potential approaches for formulating the questions and scope of systematic reviews of complex interventions.
It detected the retinal function of the central @number@ degrees of the macular by using the MP-1 microperimetry.
It determines the level of coping with various difficult situations , which accompany an old age stage.
It develops a \ "situated biographies \ " model to conceptualize how life course change may influence women's health.
It develops slowly and early signs of dementia are very subtle.
It did not.
It did not alter CYP17 and CYP21 mRNA expression , nor protein degradation.
It did not cause infection , extrusion , migration , or adverse reactions in the patients who have been followed for two years.
It did so by ensuring acquisition of reproductive competence , post-reproductive development of parents to nurture offspring and thereby , to guarantee species survival.
It differs from a mood disorder , but it can often be associated with one.
It discusses a number of methodological issues raised by differential weighting of health gains by age of recipient.
It discusses both why that has occurred and the effects of the fragmentation on participants.
It discusses the additional insights possible when capturing longitudinal consumption patterns in lieu of reliance on recent intake alone.
It discusses the most powerful antioxidant supplementation options as a possible strategy to reduce the cardiovascular toxicity effects of chemotherapy in the elderly.
It discusses the occurrence and role of nuclear amyloid in the diseased as well as the healthy cell.
It displays DS-relevant features of learning / memory deficits and age-related loss of functional markers in basal forebrain cholinergic neurons.
It documents a pattern of variation over time that is distinct from prior research , with no evidence for chronic low-grade inflammation.
It does , however , predict worse lung function.
It does provide some support for using ßDG to identify patients at high risk of IC.
It draws on an original data set of legislation in this area introduced between @number@ and @number@ ( n = @number@ ) .
It efficiently integrates information from care partners so that it can help guide decision-making.
Item analysis and exploratory factor analysis were carried out on data from @number@ self-administered questionnaires collected from @number@ selected home care organizations.
Item consistency was established with acceptable to high Cronbach alpha coefficients.
Item face validity was investigated by means of @number@ semi-structured interviews.
Item-level harmonization enables direct comparison of physical functioning measures across existing and potentially future studies and across levels of function using a nationally representative metric.
Item-person maps were also examined for checking the location of the item's difficulty and person's measures along the same scale.
It employs a probabilistic framework for unified segmentation based correction of R1 maps for B1 ( + ) inhomogeneities ( UNICORT ) .
Item reliability ( value = .92 ) and item separation ( value = @time@ ) estimates indicated that eHEALS responses were reliable and stable.
Item scores were generated from @number@ = least important to @number@ = most important.
Items from two coping scales were factor analyzed , and Pearson's correlations and paired-samples t-tests assessed relative and absolute stability of the resultant coping strategies.
Items in the first factor reflected the concept of TB , whereas items in the second factor were consistent with the concept of PB.
Items scored positive in the CFI-S and subtypes identified by SASS in different individuals provide targets for personalized ( psycho ) therapy.
Items were refined after cognitive interview pretesting and field-tested among symptomatic postmenopausal women enrolled in a multiethnic cohort study in California.
Item-to-total correlation coefficients ranged from @number@ to @number@ and items were excluded with item-to-total correlations coefficients lower than @number@
Item-to-total correlation varied between @number@ and @number@ and Cronbach's Alpha for all items was > 0.92.
It encodes a type-I membrane protein expressed in two forms , membrane and secreted.
It encompasses a series of different biologic and physiologic characteristics.
It encompasses multiple subspecialties of geriatrics , anatomic pathology , molecular pathology , clinical pathology , and gerontology.
It enhances the activity of the GABAergic neurotransmission and affects neuronal activities.
It ensures a good temporal effect but there is nearly no improvement at the mid-pupilla level.
It entrains central and peripheral circadian clocks and is required for some high-amplitude rhythms.
Iterations in the rate and extent of protein synthesis , accuracy , post-translational modifications and turnover are among the main molecular characteristics of aging.
Iterative focus groups provided feedback on paper drafts and online prototypes.
Iterative thematic analysis was used to analyze the data along with the use of a feminist political economy framework.
It establishes that the iCell neurons are a novel tool to investigate cellular and molecular mechanisms for TD-induced neurodegeneration.
It eventually requires medication if lifestyle modifications are not initiated or do not control the blood pressure well enough.
It examines the pros and cons of mentor programs and characteristics of programs that are more or less effective for achieving specific social goals.
It exerts strong antioxidative and anti-inflammatory activities and also exhibits anti-convulsive , anxiolytic , and mild sedative actions.
It exhibits viscoelastic properties that may change during aging.
It explores the political discourse on older volunteers , and how this discourse translates into policies.
It extended the life span of normal fibroblasts , slowing the aging process as evidenced by a lower level of the senescence associated beta-galactosidase.
It failed to show the influence of end-stage disease on LDL subfraction levels.
It focuses on synthetic inert prostheses ( keratoprostheses ) , acellular scaffolds with and without enhancement of endogenous regeneration , and cell-based replacements.
It follows earlier work that identified the importance of transitions from work for women of the baby boomer generation.
It follows that the results of these trials are not applicable in the real world and potentially harmful.
It found that aging and COPD altered the body composition differently , and the effect was most pronounced in leg lean mass.
It found that around three-quarters of those not working have been able to avoid low-income status.
It functions as a dual antioxidant that can neutralize free radicals and increase intrinsic antioxidant capacity.
It generally refers to employees ' capacities to function in work throughout their working life.
It generates a monodimensional nosological risk profile , grounding its roots in the somewhat inadequate framework of disease.
It gives an overview of the problem.
It gradually decreases with age.
It grows throughout lifetime with our experiences and is built up from general self-knowledge and specific memories.
It has a complex phenotype given by genetic heterogeneity.
It has added biomarkers of cardiovascular risk.
It has a direct as well as an indirect ( via psychological empowerment ) effect on the desired retirement age.
It has a great advantage over other forms of RF by being entirely painless.
It has also become clear that abnormalities in mitochondrial division and fusion are linked to the pathophysiology of metabolic diseases such as diabetes and obesity.
It has also been associated with reduced functionality and altered distribution of immune cells , especially T cells.
It has also been observed that an increase in bone mechanical strength is not necessarily reflected in densitometric evaluation.
It has also been postulated to be an important mechanism for functional cellular diversity , including the brain.
It has also been proposed that reforms promoting free choice might increase inequalities in health care use.
It has also been reported to reduce inflammation in DCs.
It has also been suggested that persons with dementia may be at risk for inappropriate treatment of pain with psychotropics.
It has also beneficial effects on neighboring esthetic units.
It has also demonstrated the ability of the Visante AS-OCT to detect small changes in lens thickness with accommodation.
It has also described the benefits , goals and outcomes of a mentoring relationship.
It has also not been shown whether this epigenetic clock is unique to humans or conserved in the more experimentally tractable mouse.
It has also reported that ART using testosterone ointment once or twice a day appeared to improve those LOH symptoms.
It has a moderately positive effect on employment outcomes , which are highest for West German men.
It has an important impact on the individual's physical and mental health and its natural progression can lead to serious pathological situations.
It has an incidence of @number@ in @number@ million and results from a mutation of the LMNA gene causing nuclear instability.
It has a serious effect on the quality of life of elderly individuals and increases their risk of developing physical and mental diseases.
It has a significant impact on exercise tolerance , thus worsening the patients ' quality of life and survival.
It has a significant mortality and is associated with a high incidence of hospitalisation and morbidity.
It has attracted the attention of many researchers in melanoma due to its high ratio of mutation.
It has become a current social trend for women to delay childbearing.
It has become clear that factors other than neurodegeneration affect αS concentrations in these tissue samples , such as genetic and environmental influences.
It has become increasingly important to optimize pre-transplant risk assessment in order to improve HCT decision making and clinical trial assignments.
It has been a decade since the first surprising discovery that longer telomeres in humans are statistically associated with longer life expectancies.
It has been aggressively marketed and sold in large quantities as a dietary supplement.
It has been also implicated in various diseases including cancer and neurodegenerative diseases , reflecting its relevance in fundamental biological processes.
It has been also reported that microglial neuroprotective or neurotoxic effects in adult neurogenesis occur in a context-dependent manner.
It has been analyzed auxological data , systolic and diastolic blood pressure and carotid intima-media thickness.
It has been argued , however , that aging does not cause a decline , but only changes in style and content.
It has been associated with tumor activation , immune suppression and aging , owing to the secretion of proinflammatory mediators.
It has been confirmed that dMSCs can activate or differentiate into FBs to participate in wound healing by producing and expressing TGF-β and other cytokines.
It has been considered that the elderly have clinical manifestations different from the ones observed in middle-age adults during an injury event.
It has been demonstrated that blueberry supplementation can allay age-related behavioral deficits.
It has been demonstrated that epigenetic drift affects most of the genome , suggesting a global deregulation of DNAm patterns with age.
It has been demonstrated that even the slightest degree of metabolic acidosis produces insulin resistance in healthy humans.
It has been demonstrated that post-transplant stressors accelerate aging of the allografts manifested through telomere shortening.
It has been determined that about @percent@ of patients aged @number@ or older with confusion of unknown origin have non-convulsive status epilepticus.
It has been difficult to identify genes affecting drug response to Selective Serotonin Reuptake Inhibitors ( SSRIs ) .
It has been established that normal human diploid fibroblasts can proliferate in culture for only finite periods of time.
It has been estimated that 15-30% of stroke patients become permanently disabled.
It has been estimated that as many as @percent@ of older adults complain about difficulty initiating or maintaining sleep.
It has been firmly established that ageing constitutes a principal risk factor for cardiac disease.
It has been found that synaptic activity facilitates APP internalization and influences APP cleavage.
It has been found to enhance explicit memories in both adults and children.
It has been generally accepted that it occurs due to PA having a direct effect on longevity.
It has been generally accepted that the left hemisphere is more functionally specialized for language than the right hemisphere for right-handed monolinguals.
It has been hypothesised that increased asthma prevalence in westernised countries is associated with changes in lifestyle factors , including a poorer diet.
It has been hypothesized that age-related hearing loss is caused not only by peripheral but also central changes in the auditory system.
It has been hypothesized that alterations in the production and processing of amyloid beta ( Aβ ) may be the principal pathological process in AD.
It has been hypothesized that individual differences in network connectivity impact the recruitment of brain areas during task execution.
It has been hypothesized that physiological doses of testosterone would have a beneficial effect on tissue factor-induced thrombin generation and the development of CVD.
It has been hypothesized that rapid temporal processing deficits may be linked to impaired language development through interference with acoustic information during speech perception.
It has been hypothesized that they may be partially responsible for loss of visual function and visual field.
It has been implicated with dysfunction in primary cilia.
It has been known for over half a century that all organisms have the ability to restore genomic integrity through DNA repair.
It has been modeled by the Langevin and the Fokker-Planck equations.
It has been more recently recognized that ARBs are neuroprotective and have potential therapeutic use in many brain disorders.
It has been observed that male patients develop the disease earlier and present with more severe phenotypes as compared to females.
It has been observed that subjective age ( SA ) often trails chronological age , especially in older adults.
It has been postulated that supraphysiological estrogen levels could promote the progression of moles to melanoma.
It has been postulated that the cytoskeleton controls many aspects of T cell function , including activation , proliferation and apoptosis.
It has been previously demonstrated that bone mineral density decreases with age.
It has been proposed previously that SIRT6 is a tumor suppressor in cancer.
It has been proposed that aging results from the lifelong accumulation of intracellular damage via reactions with reactive oxygen species ( ROS ) .
It has been proposed that an increase in the shortening velocity of airway smooth muscle ( ASM ) could contribute to AHR.
It has been proposed that DNA-protein cross-links formed in cells are subject to proteolytic degradation to the corresponding DNA-peptide cross-links ( DpCs ) .
It has been proposed that guanine-rich DNA forms four-stranded structures in vivo called G-quadruplexes or G4 DNA.
It has been proposed that the DLPFC is dynamically recruited depending on task demands.
It has been proposed that the recognition of endogenous ligands by pathogen recognition receptors ( PRRs ) may be involved in the induction of chronoinflammaging.
It has been proposed that this default activity is concerned with internal thought processes.
It has been proved that the melatonin concentration in human serum could significantly increase after the consumption of melatonin containing food.
It has been recently demonstrated that cognitive reserve , as measured by years of formal schooling , can counteract the ongoing pathological process.
It has been recently reported that HIV-1 Tat transactivation requires menin , suggesting that menin may be involved in HAND pathogenesis.
It has been reported that age differences in cortico-striatal connectivity relate to cognitive declines in aging.
It has been reported that aging , bone loss , coarse osteocyte network , reduced bone remodeling cause accumulation of microdamage in bone.
It has been reported that angiotensin-converting enzyme ( ACE ) gene insertion / deletion ( I / D ) polymorphisms are associated with human performance.
It has been reported that argyrophilic grains are more frequent in patients with corticobasal degeneration ( CBD ) compared with the elderly population in general.
It has been reported that both anti-resorptive agents and anabolic PTH increase bone strength in different manner.
It has been reported that low cell-cholesterol efflux capacity ( CEC ) of HDL is an independent risk factor for CVD.
It has been reported that mitochondrial metabolic and biophysical parameters are associated with degenerative diseases and the aging process.
It has been reported that Mitofusin2 ( Mfn2 ) inhibits cell proliferation when overexpressed.
It has been reported that mutations in optineurin ( OPTN ) can cause ALS.
It has been reported that stem cells can reside in the skin tissues , including the epidermis , dermis , hair follicles and subcutaneous tissues.
It has been reported to exert a protective effect against hepatic steatosis by attenuating endoplasmic reticulum ( ER ) stress.
It has been shown however , that human tau overexpression in amyloid precursor protein transgenic mice increases Aβ plaque deposition.
It has been shown previously that the N-glycosylation pattern of human immunoglobulin G ( IgG ) is age-dependent.
It has been shown that ABL results from mutations in the gene encoding the microsomal triglyceride transfer protein ( MTTP ) .
It has been shown that age-related decline in androgen secretion is associated with cognitive impairment and the risk of dementia.
It has been shown that also has a central role in the prevention of oxidation of plasma lipoproteins.
It has been shown that healthy aging affects the ability to focus attention on a given task and to ignore distractors.
It has been shown that NAbs regulate immune system , and can be changed during the individual's life.
It has been shown that one of the main actions resulting from NO modulation is sirtuin regulation , especially SIRT-1 regulation.
It has been shown that pathogen-specific secretory IgA ( SIgA ) antibody ( Ab ) is the major player at mucosal surfaces for host defense.
It has been shown that the extent and diversity of informal tasks may jeopardize the physical , mental and social wellbeing of caregivers.
It has been shown that Wnt signaling is antagonized by the protein Klotho , which has been implicated in aging.
It has been shown that young and old animals differed in intensity loss and recovery of body weight after three cycles CFR.
It has been shown to be an effective model in terms of reducing both length of stay and avoiding readmission.
It has been shown to exhibit anti-oxidative and anti-inflammation activity , and to reverse the effects of aging.
It has been shown to have anti-tumor and anti-inflammatory properties , but no reports have yet described the effects of n-butylidenephthalide on PD.
It has been suggested previously that BMS is a small-fiber neuropathy.
It has been suggested that accumulation of DNA damage may contribute to breast carcinogenesis.
It has been suggested that age-related alterations of this pattern are associated with changes in neural efficiency and capacity.
It has been suggested that arterial stiffness is one of the most important risk factors for the development of a cardiac infarction or stroke.
It has been suggested that chronic dizziness in older people may constitute a multifactorial geriatric syndrome.
It has been suggested that combination treatments can result in a better overall improvement.
It has been suggested that curcumin can play a beneficial role in the cardiovascular system.
It has been suggested that expert outlining yields poorer reproducibility as compared to automated methods , but this has not been investigated.
It has been suggested that functional and structural alterations of the BFCS mediate cognitive performance in normal aging and AD.
It has been suggested that highly modified proteins and undegradable protein aggregates also affect the intracellular proteolytic systems.
It has been suggested that human mitochondrial variants influence maximal oxygen uptake ( VO2max ) .
It has been suggested that inflammation is involved in Alzheimer disease ( AD ) pathogenesis.
It has been suggested that initial collagen contraction and thermal damage modulate wound healing.
It has been suggested that normal aging might be associated with a decline of the right hemisphere.
It has been suggested that the postprandial increase in circulating insulin modulates the muscle protein synthetic response to feeding.
It has been suggested that this effect is due to inhibition of nitric oxide ( NO ) -mediated vasodilation after transfusion of older RBC units.
It has been thought that for scientific acceptance of a parameter , its psychometric properties such as reliability , validity and responsiveness have critical roles.
It has been unveiled that manipulation of various key pathways may decelerate the aging progression and the triggering of age-related diseases.
It has been validated and is appropriate for use in research or for everyday clinical use for both live and photographic assessment.
It has been well correlated with all-cause mortality among HIV-infected patients.
It has been well established that nuclear factor kappa-B ( NF-κB ) activation is important for tumor cell growth and survival.
It has been well established that the volume of several subcortical structures decreases in relation to age.
It has been widely demonstrated that ageing has a strong impact on the remodelling of the B cell branch of immune system.
It has brought more hope than ever of increasing the size of primordial follicle pool , improving ovarian function and delaying ovarian consenescence.
It has evolved by incorporating a previously untranslated region of the LHβ gene into the reading frame.
It has evolved intricate metabolic networks to fulfill this need and utilizes a variety of substrates to generate ATP , the universal energy currency.
It has excellent patient tolerability , minimal complications , and excellent patient satisfaction.
It has frequently been associated with cystic fibrosis ( CF ) .
It has furthermore been suggested that telomeres may play a role in aging and age-related diseases.
It has gained much attention for its potential anticancer activity against various types of human cancer.
It has gained much attention for its potential anticancer activity against various types of human cancer.
It has high affinity for copper ions and easily forms a copper complex or GHK-Cu.
It has implications for realizing the goal of aging in place.
It has in ageing a more heterogeneous clinical presentation.
It has known that the glycosylation plays an important role in the biological states , such as development , aging , and diseases.
It has long been assumed that people treat cognitive effort as costly , but also that such effort costs may vary greatly across individuals.
It has long been known that human cognitive function improves through young adulthood and then declines across the later life span.
It has mean relative SD @percent@ and precision @percent@.
It has multiple current and emerging indications , and an enormous potential for growth.
It has not been studied in older people with a high prevalence of vitamin D insufficiency.
It has pleiotropic effects on the cardiovascular system : vascular protection , improvement of myocardial ischemic tolerance and retardation of cardiac senescence.
It has previously been reported that the lack of Lamin A / C expression in lymphoma and leukaemia is due to CpG island promoter hypermethylation.
It has previously been shown that hAECs express hepatocyte-related gene and possess intracellular features and functional properties of hepatocytes.
It has recently been reported that sleeping and eating habits change the brain structure of children.
It has recently been shown that RRM3 also contributes to binding , with preferential binding for C-rich sequences.
It has remained unclear , however , whether the age of a grafted liver can be modulated by recipient factors.
It has serious implications for health expenditure , which accounts for nearly @percent@ of overall government expenditure.
It has since long been hypothesized that mutation accumulation in somatic cells of multicellular organisms could causally contribute to age-related cellular degeneration and death.
It has the ability to produce various three-dimensional ( 3D ) images.
It has the possibility of becoming a radical treatment if eligible patients and concurrent treatment are carefully selected.
It has therefore become an important public health matter to evaluate those interventions that might be effective in reducing the risk of falls.
It has therefore been concluded that treatment and prevention of such changes in old age should increase healthspan and delay death.
It has thus become challenging for physicians to identify drugs causing adverse events.
It has yet to be determined whether impaired cellular quality control mechanisms contribute to this process.
It highlights the utility of the 18F-FDG PET / CT scan as a valuable diagnostic modality.
I this Perspective , we further extended the gerosuppression model.
It holds two resident populations of SCs : epidermal stem cells and melanocyte stem cells.
It , however , showed no association with happiness.
It identified a real-life macro level social outcome of a micro level laboratory phenomenon , which can be an important direction for future research.
It illustrates how older transgendered adults carry physical and mental scars from previously encountered transphobia , which affect various aspects of later life.
It impacts postural control and increases the risk of falls.
It impacts quality of life.
It impairs several physiologic patterns related to cerebrovascular hemodynamics and homeostasis.
It implies an operational specification of the classification into Robust , postRobust , preFrail and Frail.
It implies a specific cognitive ability concerning the perception , interpretation , and self-regulation of bodily sensations.
It included a standardized structured questionnaire on staff , hospitalization , outpatients , consultation , research and teaching.
It included multiple self-reported measures of positive psychological functioning ( e.g. , resilience and optimism ) , as well as depression and HRQoL.
It included @number@ patients with PMR , @number@ with GCA , @number@ with EORA , and @number@ age-matched HCs.
It included patients aged ≥65 years , in whom antiplatelet medication was initiated following a TIA diagnosis during the period between @date@ and @date@ .
It includes a review of the relevant literature and pointers to the future.
It includes the notion that older drivers will avoid driving in specific , usually self-identified situations , such as those in which safety is compromised.
It includes tumour types that range from localised papillary carcinomas to lethal anaplastic disease.
It increased gradually from the center to the periphery ( P < @number@ ) .
It increased steeply with increasing age to a maximum of @percent@ for those aged @number@ years or older.
It increases bone formation through osteoblast differentiation , cell adhesion , Wnt signalling and collagen cross-linking.
It increases with age and is accelerated by hypertension and other cardiovascular risk factors.
It increases with age , while the endogenous defense mechanisms that counter them decrease.
It indicated that the scaffolds with KDIOP possess potential application in tissue engineering.
It indicates that the glycation products decreases the polarity microenvironment around the fluorophores.
It induced collagen generation in the dermis and fat layers and was effective and safe in our study population.
It induces several Alzheimer pathomechanisms like oxidative stress , Ca ( + + ) influx , accumulation of hyperphosphorylated tau and β-amyloid.
It informs design of future CPT studies and directs consideration of methodological variability and child age when interpreting study findings.
It inhibits cell proliferation and promotes apoptosis of tumour cells but suppresses it the nervous tissue.
It interacts with several relevant pathways , like PDE , TGF-ß , MAPK , PPAR , NOS , IGF , Sirtuin , and others.
It involved patients aged 65 + years living in Aarhus , Denmark who used five drugs or more without assistance.
It involves multiple changes in many components that play fundamental roles under healthy and pathological conditions.
It involves : ( @number@ ) SCF-expressing cells communicate with neighboring KIT-expressing cells directly or indirectly ( cleaved soluble SCF ) .
It involves numerous endocrine disorders as etiological factors or as complications.
It involves weekly group sessions over @number@ months and one to one sessions.
It is a 365 / @date@ embedded system permitting unobtrusive fall detection as well as preserving privacy of the user.
It is absorbed by chromophores in the skin , such as melanin , DNA , RNA , proteins , lipids and aromatic amino acids.
It is a captivating era to be working in neurology as recent years have engendered fascinating developments.
It is accompanied by circadian rhythm disturbances associated with impaired functioning of the suprachiasmatic nucleus , the biological clock of the brain.
It is acknowledged that the development of the venous system is subject to many variations and that these variations do not necessarily represent pathological findings.
It is a common condition but often underdiagnosed and undertreated.
It is a common , serious , and often fatal condition among older patients.
It is a common site of cancer , and unlike other glands , it typically enlarges in aging men.
It is a complex disease that is profoundly influenced by both genetic and environmental factors.
It is a complex system that consists of a large number of components performing different functions.
It is a computer-guided system that delivers treatment through compressed air molecules of HA to the dermal layer of the skin.
It is a condition with a complex etiology and pathophysiology.
It is active either as response to starvation or molecular damage.
It is affected by internal signals such as posture and constitution of refluxate , aging , and interventions particularly radiation and surgery.
It is a frequent condition in older adults , leading to undesirable adverse outcomes.
It is a lethal and progressive neurodegenerative disease , principally affecting motor neurons ; patient clinical characteristics are muscle weakness , dysphagia and respiratory failure.
It is a limitation of the current study that its cross-sectional nature does not allow for assessment of cause-effect relationships.
It is all in the choosing.
It is also a critical period for brain reorganization and it is vulnerable to exposure to certain environmental factors.
It is also an important etiological factor of consequent cardiometabolic and autoimmune disorders.
It is also a site for their synthesis.
It is also associated with morbidity and mortality.
It is also associated with premature aging and increased mortality.
It is also a topic of interest and debate throughout Korea.
It is also becoming clear that somatic mutations , including those in known oncogenic drivers , are common in tissues starting at a young age.
It is also being seen as one approach that may have a beneficial impact on reducing health care budgets.
It is also demonstrated that depletion of p16INK4A induces senescence in HeLa but not CaSki or MS-751 cervical carcinoma cells.
It is also designated as the lead within NIH for research on Alzheimer's disease.
It is also essential to take the Laotian-specific context into consideration during intervention development and implementation.
It is also estimated that @percent@ of the variance of non-pathological cognitive aging is accounted for by common single nucleotide polymorphisms.
It is also identified that the modulation of p53 by scopoletin are related to the induction of autophagy.
It is also implicated in allergic skin conditions such as atopic dermatitis and eczema.
It is also includes some of the newest references of others on various closely-related aspects of this ageing system.
It is also known to be substantially heritable.
It is also necessary to develop the organic cooperation with other medical and nursing care professionals , such as registered nurses and care workers.
It is also noted that the spatial topography of tau accumulation is markedly distinct to that of amyloid burden in aging and AD.
It is also not known to develop cancer.
It is also now well understood that mitochondrial function declines with age.
It is also of interest to investigate factors related to health and quality of life associated with the age of retirement.
It is , also , one of the most important sources of medical costs.
It is also possible that pre-existing pathology and vascular risk may already be present outweighing any effect related to lipids.
It is also present in a subset of Alzheimer's disease cases.
It is also present in very small amounts in men and non-pregnant women.
It is also reasonable to hypothesize that the mitochondria contain fidelity proteins similar to those found in the nucleus and cytoplasm.
It is also reported that patients with higher CAVI values have a poor prognosis compared with those with lower CAVI values.
It is also suggested that functional mitochondria are essentially antiaging agents , while their dysfunction or inactivity accelerate ROS formation and aging.
It is also the first study presenting the association between SIRT1 expression in older people and rs7895833 in SIRT1 gene.
It is also the first study to demonstrate potential sex-specific profiles among schizophrenia cases with hypovitaminosis.
It is also thought-provoking.
It is also timely to consider the service provision changes that will increasingly be needed to effectively manage the needs of the aging population.
It is also uncertain whether these women differ from their peers in the hormonal or metabolic profile.
It is also unclear if PPIase and chaperone activities reflect distinct cyclophilin properties.
It is also unclear if religious beliefs influence the health attitudes and behaviors of men.
It is also unclear whether ageing modulates any such adjustments.
It is also unclear whether heat shock proteins ( Hsp's ) differentially modulate skeletal muscle and spinal cord protein structure during ALS disease progression.
It is also used as an ingredient of healthy food , wine , tea , biological toothpaste.
It is also useful for detecting cognitive impairment and dementia in the elderly and for assessing disease evolution and treatment effectiveness.
It is also useful in the evaluation of the effects of lifestyle modification.
It is always possible to improve conversation by paying attention to one's own style of communication and constructing of the situation.
It is a major cause of blindness in the aging population.
It is a major inducer of matrix metalloproteinase @number@ and is selectively toxic for motor neurons.
It is a major public health epidemic worldwide , and a known risk factor for the development of cognitive dysfunction and dementia.
It is a multifactorial degeneration characterized by chronic inflammation , oxidative stress and aging components.
It is a multifactorial disease with several overlapping pathways.
It is a multifactorial disorder and identification of risk factors enables individuals to make life style choices that may reduce the risk of disease.
It is a multi-functional protein expressed in the kidneys , brain , pancreatic beta cells , other tissues , and is cell-bound or soluble.
It is a multisystem disorder characterized by symmetric proximal , extensor , inflammatory myopathy , vascular involvement and a characteristic cutaneous eruption.
It is an acknowledged fact that health benefits are derived from fruit- and vegetables-enriched diets.
It is an age-related problem and increases especially in people aged above @number@ years.
It is analyzed in Denmark , Finland , Norway , and Sweden during the period 1994-2011 , and all possible models are screened.
It is an anguishing experience for a professional community to deal with a colleague's impairment.
It is a nation that has experienced enormous economic , social , and demographic changes over the past three and a half decades.
It is a natural and irreversible process which can run as successful aging , typical or pathological.
It is an important area of research , given the growing elderly population.
It is an inappropriate facial expression of sadness or grief that most often motivates the patient to schedule a consultation with the plastic surgeon.
It is an independent mortality predictor of hemodialysis patients and indicator of adverse outcome of transplanted patients.
It is an infinitely more complex disease than it was believed when first described in the mid part of the 20th century.
It is an OCT finding that is almost always the result of normal vitreous aging , which may lead to pathologic conditions.
It is a nonspecific sign developing most commonly among patients with a relatively advanced age at presentation.
It is anticipated that a biomedical \ "big data \ "-based disease prediction model may assist the diagnosis of any disease more correctly.
It is anticipated that a boost in disease-related proteomic data is expected in the very near future.
It is anticipated that hLRG CSF levels will be a useful biomarker for the early diagnosis of PDD and PSP.
It is a phenomenon that increases in prevalence as people age.
It is a popular filler for volume restoration to the face , and also to nonfacial areas such as the dorsum of the hands.
It is apparent that membrane composition is regulated for each species.
It is apparent that SPSA is a multidimensional construct that cannot be defined by physical functioning alone.
It is apparent that with the aging population , more elderly patients are being referred for surgery.
It is appropriate to engage stakeholders from these populations in new governance arrangements.
It is a predominantly plant-based diet , with olive oil being the main type of added fat.
It is a proposal which application in the outpatient and inpatient context is possible and feasible.
It is a proved fact there is a decrease of androgen levels associated with aging.
It is a quite complicated pathophysiologic event which lacks an effective and specific therapeutic method in clinic.
It is a reasonable surmise that these enzymes exhibit similar ambiguity with respect to genome maintenance and gene transcription as their nuclear counterparts.
It is a Reference Site of the EIP on AHA.
It is a reliable technique to improve malar mounds , palpebral bags , or festoons.
It is as an alternative home exercise program for older adults in rehabilitation for PD.
It is as easy to apply to a sample of beta values as beta regression and M-value regression.
It is a social and cultural problem , which is difficult to solve because of incomplete , changing , and contradictory requirements.
It is associated with an inter-operable tablet for physicians and other health care professionals.
It is associated with a pro-inflammatory status.
It is associated with high morbidity and mortality.
It is associated with high sun exposure during leisure or work , and moderate to heavy smoking , and therefore is preventable.
It is associated with increased morbidity , mortality and healthcare costs.
It is associated with low bone density and microstructural deterioration.
It is associated with multi-organ involvement and increased all-cause mortality , resembling a precocious aging process.
It is associated with neuronal loss and reduced functioning of cholinergic networks.
It is associated with severe hypothalamic hypocretin deficiency , especially in patients with cataplexy ( loss of tonus ) .
It is assumed that IL- @date@ involve in the inflammation pathology of surrounding senile plaques in Alzheimer's disease ( AD ) patients.
It is assumed that the number of patients with osteoporosis will increase by @percent@ in every @number@ years in the 21st century.
It is at present unknown whether these correlations are significant in the patient population of primary healthcare.
It is a truth universally acknowledged that although men tend to have better health in old age , women live longer lives.
It is attributed that the developed HDPE / HA nano-composites could be a good alternative material for bone tissue regeneration due to their acceptable properties.
It is a unique tool to investigate the effects of glycation on skin and to screen new molecules that could prevent AGEs formation.
It is available in most laboratories although commonly used methods are not fully satisfactory.
It is based on computational prediction as well as experimental data.
It is based on nine semi-structured interviews of relatively healthy and functional Greek centenarians of both sexes.
It is becoming clear , that a single polyphenol is impacting several cellular pathways.
It is becoming increasingly apparent that female gender is a marker that places them at increased risk of high burden and less support.
It is becoming increasingly apparent that mitochondria in mammalian cells play critical roles in the initiation and propagation of various signaling cascades.
It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes.
It is being used in National Eye Institute / Age-Related Eye Disease Study II to evaluate age-related macular degeneration ( AMD ) geographic atrophy expansion.
It is believed that an increased mechanosensitivity of HGPS cells is a causative factor for vascular cell death and vascular diseases in HGPS patients.
It is believed that cellular senescence accompanies age-related changes in the cardiovascular system.
It is believed that frequency specific information extracted from different spectra may delineate the complex yet subtle variations of BOLD signals more effectively.
It is believed that the mechanisms of aging have a universal character and they are conserved in a wide range of organisms.
It is better to anticipate the various future scenarios than react to a reality which is a fait accompli.
It is better to turn to ultrafiltration profiles , controlled blood volume dialysis and possible long-duration dialysis , preferably nocturnal or daily dialyses.
It is both a randomised controlled trial and an implementation study , containing the collection and analysis of both qualitative and quantitative data.
It is caused by a trisomy of chromosome @number@
It is caused by dengue viruses ( DENV ) and the mosquito Aedes aegypti is its primary vector.
It is certain that advancement in this direction will evolve a new landscape for innovative antiaging cosmeceuticals.
It is challenging to differentiate the mechanical properties of synergist muscles in vivo.
It is characterized as an incompetent detrusor contraction with reduced strength and / or duration to completely empty the bladder.
It is characterized by a decline in auditory function.
It is characterized by a general appearance of premature aging , diabetes mellitus , and atherosclerosis , and an increased risk of malignancies.
It is characterized by a progressive loss of function in multiple tissues , which leads to an increased probability of death.
It is characterized by a strong cell cycle arrest associated with several molecular , metabolic and morphologic changes.
It is characterized by balance impairment , urinary incontinence and dementia development caused by disorders in the cerebrospinal fluid ( CSF ) circulation.
It is characterized by dwarfism and obesity , and is caused by deletion or mutations of the growth hormone receptor ( GH-R ) gene.
It is characterized by memory dysfunction , loss of lexical access , spatial and temporal disorientation and impairment of judgement clinically.
It is characterized by progressive memory loss , confusion , and other behavioral and physiological problems.
It is characterized by reduced bone mass and microarchitectural deterioration of bone tissue , with a consequent increase in the risk of fracture.
It is characterized by reduced hearing thresholds and speech understanding with the well-known negative consequences for communication and quality of social life.
It is classified as primary form with unknown cause and as secondary form with known etiology.
It is classified into several types according to the cerebrovascular amyloid proteins involved.
It is clear that additional research is needed on optimal levels of protection against ultraviolet radiation for people of color.
It is clear that changes in the nature of chronic HIV infection put it in internal medicine.
It is clear that miRNAs regulate pancreatic islet development , maturation , and function in vivo.
It is clear that the spectrotemporal characteristics of signals and noises play an important role in determining the morphology of neural responses.
It is clear that with chronological aging both oocyte quantity ( ultimately leading to menopause ) and quality ( pregnancy potential ) decline.
It is co-expressed with PS1 in specific neuronal cells in mouse brain.
It is commonly assumed that smiling faces are perceived as younger than faces carrying a neutral expression.
It is commonly found that memory for context declines disproportionately with aging , arguably due to a general age-related deficit in associative memory processes.
It is conceivable that stimulating proteasome activity for rapid removal of misfolded and oxidized proteins is a promising strategy to prevent and alleviate aging-related diseases.
It is conceivable that synergistic effects of these two mutations might be responsible for the unusual phenotype.
It is conceivable to anticipate that long , noncoding RNAs will map to many of these \ "gene deserts. \ "
It is concluded that a low-dosed multivitamin and -mineral supplementation have different effects on the redox status in young versus old.
It is concluded that application of adequate ethical platform markedly facilitates recruitment of older persons for participation in research.
It is concluded that at the current time the evidence that these aspects of brain structure are neuroanatomical substrates of age-related cognitive decline is weak.
It is concluded that decreased coupling between large-scale functional network modules is a hallmark for impaired cognition in childhood FLE.
It is concluded that educational opportunities are a significant protective factor for ToM abilities in elderly populations.
It is concluded that health disparities need to be recognized and addressed in all health care service provision and education.
It is concluded that hormone replacement therapy increases longevity.
It is concluded that in mechanisms of skin aging of menopausal women estrogen-depending alterations in redox-balance places important role.
It is concluded that interventions incorporating age-appearance morphing techniques are likely to be effective in helping women to take active steps to quit smoking.
It is concluded that menopausal symptoms referred to in the literature must be questioned to be phase specific.
It is concluded that movement velocity is an increasingly important determinant of maximal power output with advancing age.
It is concluded that negative item effects do not reflect processes necessary for the successful encoding of item-context associations in older subjects.
It is concluded that plasma vWF level unrelated with gender but interrelates with ABO blood groups.
It is concluded that SC number does not reflect a change in regenerative ability by the muscle.
It is concluded that syntactic complexity in spoken discourse remains stable during the years that span early , middle , and later adulthood.
It is concluded that the growth in the older adult population could add to the overall burden of these nonfatal pedestrian injuries.
It is concluded that the rate of progression and severity of chronic glomerulonephritis , even within the same morphological form , is determined by age.
It is considered a robust test on its own as the inclusion of other tests failed to improve its CCR significantly.
It is considered to be the major cause of irreversible blindness in the elderly population in the developed world.
It is controversial whether or not high protein intake accelerates this decline.
It is critical to address the barriers that disproportionately affect participation in clinical research by minorities and the socioeconomically disadvantaged.
It is critical we investigate positive constructs such as resilience and mastery to determine factors associated with psychological well-being.
It is crucial for any living being to respond to these changes by buffering the effects on cellular homeostasis.
It is crucial in systemic skeletal diseases , when deformities affect limbs and the surgeon does not have an intact limb as a reference.
It is crucial that age-specific treatment guidelines are developed to optimize the outcomes for senior trauma patients.
It is crucial to consider the impact of weather in the relationship between neighbourhood walkability and older adult mobility.
It is crucial to investigate age-related body composition changes in geriatric medicine.
It is crucial to understand how specific cognitive deficits underlie functional deficits to develop successful cognitive interventions.
It is currently also unknown whether attentional problems , which are commonly observed in chronic pain , mediate the decline in memory.
It is currently being tested on a larger scale.
It is currently estimated that infections and inflammatory responses are linked to 15-20% of all deaths from cancer worldwide.
It is currently marketed as a health supplement and is well known for its antioxidant capacity.
It is currently not absolutely clear if prevalence or incidence is more important for epidemiology evaluation of nocturia.
It is currently not known whether different types of pain differently shape pain catastrophizing.
It is currently unclear if these same factors or others predict suicide ideation among older adults with BD.
It is currently unknown what role BIN1 plays in AD.
It is currently unknown whether telomerase mutations associate with cirrhosis induced by chronic liver disease.
It is debated whether exercise-induced ROS production is obligatory to cause adaptive response.
It is defined as a relevant disturbance of the internal temporal order of physiological and behavioral circadian rhythms.
It is difficult for these older adults to maintain a physically active lifestyle and to keep a positive outlook on life.
It is difficult if not impossible , therefore , to formulate valid conclusions regarding the utility of fusion for patients with uncomplicated stenosis.
It is difficult to determine whether these variants are disease-causing mutations or single-nucleotide polymorphisms.
It is difficult to devise goal-directed long-term strategies for managing osteoporosis without firm information about residual life expectancy in treated patients.
It is difficult to differentiate between the physiological symptoms of ageing and disorders in the elderly patient.
It is difficult to discriminate between disease-related and age-related alterations.
It is difficult to distinguish unexplained falls ( UFs ) from accidental falls ( AFs ) or syncope in older people.
It is disappointing that these historical and demographic facts have been ignored by the Alzheimer's disease scientific community.
It is due to very frequent and recurrent subtle temporal lobe seizures.
It is easily to be misdiagnosed due to non-specific clinical and imaging manifestations.
It is emphasized that in XX century the theories ' nature has changed abruptly many times.
It is especially important for patients with Alzheimer's disease ( AD ) , when decrease of body mass , resulting in malnutrition.
It is especially important for the elderly patients having polymorbid pathology in association with inflammatory periodontal diseases.
It is especially important to better understand factors involving in cognitive decline for the countries where the older population is growing rapidly.
It is essential for athletes to ensure that they have optimal amounts of muscle mass to ensure peak performance in their given sport.
It is essential for clinicians to recognize sleep changes to lead to appropriate treatment.
It is essential for the proper cellular activity of numerous proteins , including Ras family GTPases and heterotrimeric G-proteins.
It is essential to apply analytic methods to evaluate retrospective data to understand real world patients and medical practice.
It is essential to appreciate the distinction between chronological and physiological age.
It is essential to develop effective interventions aimed at ameliorating age-related cognitive decline.
It is essential to develop psychometrically robust measures for family caregiver burden and gain.
It is essential to optimise health services to meet current needs and prepare for anticipated future demands.
It is essential we first address population and intervention-specific methodological challenges prior to building a larger evidence base.
It is established that a high level of fat mass ( FM ) is related to mobility impairment in older adults.
It is established , that at children sensitivity to acute hypoxia above , than at teenagers , and at teenagers above , than at adults.
It is established that short peptides realize their geroprotective effect by changing gene expression of immune and proinflammatory cytokines and g-interferon.
It is estimated that 10-30 % of patients with breast cancer are diagnosed with BM.
It is estimated that more than @number@ million Americans and @number@ to @number@ million Europeans suffer from OA.
It is estimated that more than one-third of men @number@ years and older have testosterone deficiency.
It is estimated that one in five men will suffer an osteoporotic fracture during their lifetime.
It is estimated that @percent@ of the elderly population will suffer simultaneously from the two conditions.
It is estimated that the incidence of AD diagnosis doubles every @number@ years after the age of @number@
It is estimates that prevalence rates up to @percent@ and pre-frailty rates up to @percent@ qualify for the term \ "epidemic \ ".
It is evident that protein-membrane interactions change significantly with age.
It is evident that the rigidity of nuclear membranes was greater than that of cortical membranes for all age groups.
It is expected that AD , for which aging is a risk factor , will increase in the future.
It is expected that by @number@ more than a quarter of the world's population ( @percent@ ) will be @number@ years or older.
It is expected that CTA will be a more cost-effective strategy for diagnosis : yielding similar outcomes with fewer procedural risks and improved resource utilization.
It is expected that serum protein biomarkers in Duchenne muscular dystrophy ( DMD ) will reflect disease pathogenesis , progression and aid future therapy developments.
It is expressed on all cell types.
It is extremely sensitive to atrophy , wherein loss in cellularity of the thymus and / or disruption of the thymic architecture occur.
It is formulated with a proprietary peptide and offers the potential of a longer acting neurotoxin therapy.
It is found in many plants , but the highest concentration was detected in different grape-derived products , especially in red wine.
It is found that the @number@ clinical groups demonstrate very similar spatial distribution of grey matter ( GM ) loss on cortex.
It is frequently associated with several comorbid conditions , including cardiovascular disease , lower urinary tract symptoms , and testosterone deficiency.
It is frequently detected in a number of sporadic diseases , and it accumulates in many tissues during aging.
It is frequently positive in asymptomatic nasopharyngeal carriers.
It is fundamental to identify patients at risk for AKI.
It is furthermore thought to originate in a HSC and to be associated with the accrual of multiple genetic and epigenetic aberrations.
It is generally accepted that osteons are roughly circular in cross-section and deviations from circularity have been attributed to deviations from longitudinal orientation.
It is generally accepted that the basal ganglia play an important role in interval timing that requires the measurement of temporal durations.
It is generally assumed that a loss in hippocampal volume results in functional deficits that contribute to age-related cognitive decline.
It is generally assumed that type @number@ diabetes increases the risk of cognitive dysfunction in old age.
It is generally considered that Parkinson's disease is induced by specific agents that degenerate a clearly defined population of dopaminergic neurons.
It is generally sporadic.
It is gradually being replaced by the WHO Child Growth Standards in many countries.
It is highly heritable , but the underlying genes remain largely undetermined.
It is highly likely that our treatment approaches will continue to evolve as the results of ongoing clinical trials are released.
It is hoped that such advanced imaging might improve the diagnosis , treatment and outlook for patients with valvular heart disease.
It is however , an interesting alternative tool to use in the field of integrative medicine.
It is , however , an invasive procedure associated with fairly significant morbidities , long downtime , and hence poor patient acceptance.
It is however , not known whether this characteristic of human Purkinje cells is shared with other primates or other mammals.
It is , however , poorly understood how these aggregates are formed during cellular aging.
It is , however , unclear whether cognitive training within a multiple-modality program elicits an additive benefit to executive / cognitive processes.
It is , however , unclear whether these memories are also associated with greater recollection.
It is hypothesised that early prevention or management of inflammation could delay the onset or reduce the symptoms of AD.
It is hypothesised that weakness in the lower limb occurs through loss of force generation via a reduced pennation angle.
It is hypothesized that aerosolized nicotyrine could facilitate nicotine absorption , inhibit the metabolism of nicotine , and reduce a user's urge to smoke.
It is hypothesized that elevations in the level of the acute phase C-reactive protein ( CRP ) negatively affect skeletal muscle mass in elderly.
It is hypothesized that rest allows for superior consolidation of new memories.
It is hypothesized that the concept of resilient aging can serve as a useful entity in understanding mechanisms that underlie healthy aging amidst disease-related pathology.
It is hypothesized that the second pattern of cartilage mineralization may be similar to a maturation of mineralized cartilage after initial matrix vesicles-mediated cartilage mineralization.
It is hypothesized that these effects are reflective of social-comparison processes and self-protective mechanisms.
It is hypothesized that this change in population structure and medical insurance status may affect rates of elective surgeries more significantly than clinical factors.
It is impaired in a number of conditions including acute stroke , though studies so far have not found a decline in CA with age.
It is imperative that a universal definition of sarcopenia is reached soon to facilitate greater progress in research into this debilitating condition.
It is imperative that neurologists and rheumatologists recognize this disorder which may , through clinical and pathological similarities , mimic other myopathies , especially polymyositis.
It is imperative that primary care physicians screen midlife women for overweight / obesity and offer appropriate advice and referral.
It is imperative that treatment decisions are based on patient preferences , unique and likely evolving health status , and longevity.
It is imperative to stop smoking before menopause because the risk of acute myocardial infarction rises sharply thereafter.
It is important for infected persons to get tested for HIV in order to be diagnosed and medically treated.
It is important for intervention studies to be aware of this type of biological vulnerability already present in late midlife.
It is important for neurons as several neurodegenerative diseases involve hyperphosphorylation and aggregation of tau.
It is important that all nurses are cognizant of the consequences of such discourses in practice.
It is important that larger studies are conducted to provide data on upcoming devices.
It is important that suggested interventions be based upon current evidence.
It is important that the clinicians themselves inspect ECGs.
It is important that the elderly should use water soluble and not lipid soluble drugs.
It is important that workers with health complaints receive efficient health care in order to remain fully or at least partly productive.
It is important therefore that future research be undertaken to help clarify this concern.
It is important to analyze late toxicities in population based samples of women with uterine cancer.
It is important to assess less prototypic features of BPD to avoid overlooking borderline personality features in this population.
It is important to assess whether FFR is effective and safe in patients , especially elderly Chinese patients , with NSTEMI.
It is important to carefully administer beta-blocker therapy to elderly patients with heart failure , especially after considering cardiac output.
It is important to compare the trajectories of respiratory diseases with those of other chronic diseases.
It is important to consider different domains of LS when considering the impact of this important emotional indicator on mortality among older adults.
It is important to consider the perspectives of people aging with disabilities in MMC to better serve their needs.
It is important to determine the pathogenesis of central presbycusis in order to explore a feasible and effective intervention method.
It is important to evaluate the patient's condition in order to carry out operations safely.
It is important to explore how the effect of genetic variants associated long-life individuals on lipids metabolism and balance.
It is important to explore the dividing lines between these two aspects and to be aware of the large gray areas in-between.
It is important to find effective treatments that can address this problem.
It is important to focus on prevention of falls to decrease the frequency of trauma in the elderly.
It is important to identify and treat these athletes in order to prevent stress fractures and reduce the risk of osteoporosis in late adulthood.
It is important to identify factors associated with the development of LS.
It is important to identify factors limiting functionality in this population in order to reduce costs and improve both prevention and intervention.
It is important to identify modifiable risk factors to reduce the burden of olfactory impairment in aging populations.
It is important to identify which subgroups need to be targeted specifically in physical activity and fitness interventions and reference values.
It is important to include systematic renal evaluation in the follow-up programs of ELBW infants.
It is important to increase the knowledge of the impact of brain changes on cognitive function during middle age.
It is important to ingest just proportions of minerals to prevent disease , but these minerals are also secreted into the hair.
It is important to investigate the irregularities in aging-associated changes in bone , between men and women for bone strength and osteoporosis.
It is important to know the sources of social support that facilitate and promote physical activity among fulltime working adults.
It is important to look beyond chronologic age to better risk stratify patients when making treatment decisions in older patients with lung cancer.
It is important to measure the effect of service changes on patients ' choices for a more efficient allocation of resources.
It is important to monitor ex-POWs and provide them with appropriate medical and psychological treatment as they age.
It is important to note the diversity of use in reagents , instruments , and methods of analysis.
It is important to put the treatment in the context of the prognosis for patients with brain metastases.
It is important to recognize these conditions , because they may be associated with an increased mortality.
It is important to recognize this source of biological variability when considering the potential clinical utility of sclerostin measurements.
It is important to take account of UR when investigating diet-disease associations in adults.
It is important to try to make a prognosis on how the fracture is going to heal based on the type of fracture encountered.
It is important to understand aspects of performance contributing to this benefit.
It is important to understand how autophagy is regulated to identify ideal therapeutic targets for treating disease.
It is important to understand how medications affect their wellbeing , but there are many other factors that affect quality of life.
It is important to understand student nurses ' motivation for choosing gerontological nursing as a career.
It is important to understand the correlation between the clinical presentation and the individual anatomy to direct an adequate treatment.
It is important to understand the fundamental principles of various MRI techniques and their limitations to know when these techniques can best be applied.
It is important to understand whether AngII accelerates telomere shortening in GMCs and further promotes aging.
It is in complex III and IV where these dysfunctional aspects are manifested.
It is increasingly recognized as an in-hospital complication of sepsis , heart conditions , and surgery ( @number@ ) .
It is increasingly recognized that many patients require pan-facial volume restoration , and that many can benefit from combined treatments.
It is increasingly recognized that the clinical presentation or \ "cognitive phenotype \ " is variable.
It is incumbent on the practitioner to ensure that they are adequately informed , counselled and supported in this decision.
It is indicated that the method of ' replenishing qi and strengthening Shen ' has preferable effects on many diseases.
It is inevitable and time dependent.
It is inhibited by several xenobiotics and endogenous molecules including NO and erythropoietin.
It is inhibited by Trx-1 overexpression , treatment with exogenous Trx-1 , or inhibition of FAK.
It is intended that these objectives foster and focus scientific efforts in these areas in the coming decade and beyond.
It is intended to mitigate bias introduced by study participant loss to follow-up.
It is interesting that individuals with the least complex structures had the highest levels of well-being.
It is interesting to observe how humans perceive facial age.
It is intriguing to correlate aging with the decline of regenerative abilities.
It is involved in the control of apoptosis , cellular damage protection and also in modulation of immune response , all associated to healthy aging.
It is known that Alzheimer's disease ( AD ) presents at an early age in people with Down syndrome ( DS ) .
It is known that changes occur at both the bone and tendon after rotator cuff tears.
It is known that elderly people suffer from cognitive impairment , even without neurodegeneration , as a part of ' normal aging'.
It is known that immunosenescence is highly correlated to the negative effects of aging.
It is known that loss of sex hormones due to aging results in a reduction of immune functions.
It is known that males and females respond differently to stroke.
It is known that microbiota is an inducer of proinflammatory T helper @number@ cells and regulatory T cells in the intestine.
It is known that mutated tau P301L results in aggregation of tau proteins , leading to neuronal loss in the brain.
It is known that standing induces orthostatic stress on the cardiovascular system.
It is known that the chromosomal aberration is associated with the treatment response and prognosis of MM patients , and this information is indispensable.
It is known that the default mode network ( DMN ) may be modulated by a cognitive task and by performance level.
It is known that the precursors for the bone-forming osteoblasts reside in the mesenchymal cell population in bone marrow.
It is known that when the concentration of intermediates in Krebs cycle is increased , NAD ( + ) / NADH ratio will be decreased.
It is known that young female cancer survivors are at higher risk for decreased fertility and early menopause.
It is known to be associated with certain occupational risk factors.
It is likely that different components of EC , such as emotion regulation and attention , differentially interact with the stress context.
It is likely that PSA screening also contributes significantly to the differences in prostate cancer mortality rates.
It is likely that the translation of laboratory studies to humans will improve understanding and stimulate the use of physical activity to benefit cardiovascular patients.
It is likely to be correlated with the aging population and with the growing association with vascular diseases.
It is mainly composed of tight junction ( TJ ) proteins existing between endothelial cells.
It is modulated throughout life by life and reproduction-related events , health , relationships , and sociocultural variables.
It is more important to pay attention to factors that vary according to the individual state of health and life situation of the potential participants.
It is moreover imperative to gather data on subjects ' mental limitations in surveys to better evaluate the validity of answers disclosed by elderly participants.
It is more powerful than existing family-based RV association methods , particularly for the analysis of extended pedigrees and pedigrees with missing data.
It is most likely that additional information about the distribution , structure and function of glial cells will yield novel insight into human brain ageing.
It is mostly asymptomatic.
It is much more visible in individuals with skin types I and II and , less prominent in dark-skinned population.
It is multifactorial in etiology with poorly characterized molecular mechanisms.
It is necessary for the treating physician to recognize these concomitant diseases , known as comorbidities , early as they influence the management options.
It is necessary to consider the skin thickness of different facial regions when choosing the treatment depth.
It is necessary to distinguish between symptoms that are curable by short melatonergic actions and others that require extended actions during night.
It is necessary to focus on both asthma and ageing to help older people achieve good asthma outcomes.
It is necessary to identify molecular mediators of ischemic neuroprotection suitable for translation to human clinical trials.
It is necessary to plan actions that favor participation , thereby contributing to monitor their health conditions.
It is necessary to provide a new questionnaire applicable to the Chinese population to screening LOH.
It is necessary to refine these models with longitudinal clinical research studies.
It is necessary to reveal the genotypic mechanism inferred by affected genes and their interaction underlying the senescence process.
It is necessary to understand the characteristics of elderly people with diabetes and the way for the management of diabetes.
It is necessary to understand the traditional negative perceptions about ageing if we are to alter them.
It is not an essential element for life and has commonly been thought of as a rather inert and insoluble mineral.
It is not clear how representative blood changes are of the total immune status.
It is not clear if forward reach ability is also affected by aging.
It is not clear if MS imposes a greater risk of AF in elderly hypertensive patients.
It is not clear if the depression facilitates the appearance of frailty syndrome or vice versa or these two coexist independently in the same individuals.
It is not clear if the neuronal degeneration in the inner ear was primary or secondary to loss of neuroepithelial cells.
It is not clear to what extent the aging brain is capable of such plasticity.
It is not clear whether combined strategies undertaken simultaneously have a synergistic effect.
It is not clear whether more favorable Medicare reimbursement rates for those certified in geriatric psychiatry would increase the numbers seeking fellowship training.
It is not clear whether the age-related rise in sleep problems is related to aging itself or to health-related quality of life.
It is not clear whether these results generalize to other types of rewards.
It is not clear whether this positive correlation reflects a single association or a cause-effect relationship.
It is not clear why sRAGE levels vary between studies , with controversial results.
It is not easy for older drivers or their relatives to detect early signs of dangerous driving behaviors.
It is noteworthy that , in kidney , mitophagy is active , and damaged lysosomes are removed by autophagy.
It is noteworthy that poly ( ADP-ribosyl ) ation is required for nuclear gene expression of these mitochondrial proteins.
It is noteworthy that SHIP2 has been demonstrated to be a potent negative regulator of insulin signaling and insulin sensitivity.
It is noteworthy that the MUFA diet prevented the age-related increase in levels of mitochondrial DNA deletions in the brain mitochondria from aged animals.
It is noteworthy that the results were quite similar between the comparison of patients with NNHCA-IE and those with CA-IE.
It is not known for certain whether the age-related deficit is a pan-retinal effect or if there are localised regions of impaired rod function.
It is not known , however , whether acute stimulation persists long term or includes muscle cell division.
It is not known how the effects of oral protein ingestion on energy intake , appetite , and gastric emptying are modified by age.
It is not known if low BMD , central to fracture prediction in older adults , identifies fracture risk in patients with DM.
It is not known if postexercise protein feeding has a beneficial effect on protein turnover after low- to moderate-intensity exercise.
It is not known if such effects persist during ageing.
It is not known if this change is consistent over the entire hand or if sensation is affected by changes in skin mechanics.
It is not known to what extent this increased variability results from increased physiological noise versus a decreased ability to regulate walking movements.
It is not known whether Plin2 expression changes with age and if this has consequences on muscle mass and strength.
It is not known whether there are age- and / or gender-related differences in magnitude of motor-evoked potentials ( MEPs ) of the submental muscles.
It is not known whether there is a relationship between plasma levels of secreted klotho protein and longevity in humans.
It is not known whether these changes contribute to decreased immune function or are the result of declining immune function.
It is not known whether this is related to increasing GC activity with age.
It is not known whether this trend has continued.
It is not known whether vascular amylin deposition is a consequence or a trigger of vascular injury.
It is not possible to affirm that tube feeding is harmful for dementia patients.
It is not sustained heat , however , that usually causes burns ; it is a more rapid application of heat.
It is not uncommon in medical practice that multiple diagnostic tests are routinely performed or multiple disease markers are available for the same individuals.
It is not understood how aging affects the IntraMAT content of individual muscles of the thigh.
It is not understood how genetic risk factors for these disorders relate to each other over time and to what degree they are stable.
It is not yet clear how age can influence this relationship.
It is not yet clear if some genetic factors are either risk or protector for progression to dementia.
It is not yet known whether DNA methylation age captures aspects of biological age.
It is not yet possible to accurately predict the onset of menopause , especially early menopause , to give women improved control of their fertility.
It is now acknowledged that physical activity represents one of the most effective preventive agents in chronic degenerative diseases.
It is now becoming clear that resting microglia are not inactive but that they serve house-keeping functions.
It is now clear that these different inputs act through evolutionarily conserved pathways to regulate lifespan in a wide range of animals.
It is now coming to light that cannabinoid @number@ receptor ( CB1R ) agonism / antagonism influences insulin action in insulin-sensitive tissues.
It is now established that attention influences working memory ( WM ) at multiple processing stages.
It is now increasingly recognized that indices of vascular health are more reliable than age per se in predicting adverse cardiovascular outcomes.
It is now possible to estimate an \ "aggregate \ " g-ratio in vivo using MRI.
It is now recognized that ER stress contributes to many pathophysiological conditions.
It is now suspected that herniosis weakens the colonic ECM , allowing the mucosa to form diverticula by herniating alongside the vasa recta.
It is now time for scientists to get involved in leading policy on seniors and in the political arena.
It is now well admitted that intracellular and membrane localized oncogenes can illicit oncogene induced senescence.
It is observed that the @number@ μm pore size Zr-Si scaffolds support the strongest matrix mineralization , as confirmed by calcium deposition.
It is of ancient evolutionary origin , being traced back to horseshoe crabs @number@ million years ago.
It is of critical importance to neurons as it participates in the transmission of the depolarizing signal and contributes to synaptic activity.
It is of note that this inhibition effect was not p53 binding and by increasing caspase8.
It is of public health interest to evaluate whether treatment of vitamin D deficiency prevents premature deaths.
It is often argued that declining health in elderly people makes death more salient and threatening.
It is often linked to mutations in genes coding for centrosomal proteins ; however , their role in brain size regulation is not completely understood.
It is often performed while standing quietly or after standing up from a seated position.
It is often presumed that the stress of IPV may be causing greater morbidity.
It is often suggested that sleep-dependent consolidation of motor learning is impaired in older adults.
It is one of the most common causes of hypopituitarism in underdeveloped or developing countries.
It is only fair for the screening of aMCI.
It is only to be expected that the elderly population manifests a high prevalence of chronic diseases that jeopardize their autonomy.
It is open to adapt existing systems biological methodologies from other research fields and devise new aging-specific systems biological methodologies.
It is our belief that this model has sufficient flexibility to be adapted to new information as it is discovered.
It is our goal to review the importance of nutritional status in elderly patients with HF , as well as tools for assessing it.
It is our impression that future evaluation of vision will go beyond visual acuity to assess ocular health in terms of psychophysical function.
It is our objective to chart the varying prevalence of orthostatic and neurocardiogenic syncope ( NCS ) as a patient ages.
It is over-expressed and / or activated by multiple mechanisms in many common human cancers , and acts on multiple signal pathways to promote tumorigenesis.
It is particularly helpful in younger patients with platysma muscle hyperactivity and retained skin elasticity.
It is particularly important for older adults who lack family support and / or suffer from social isolation and loneliness in local communities.
It is particularly important within the context of aging and dementia , but has wider applicability to all forms of brain damage.
It is particularly relevant to differentiate patients with mild dementia from those subjects with mild cognitive impairment.
It is particularly suitable for studying decision situations that are difficult to assess empirically.
It is particularly true in some epileptic syndromes with onset in childhood.
It is planned that all participants will be re-examined after @number@ years.
It is plausible , therefore , that abnormal regulation of the mechanisms of normal aging may contribute to the pathobiology of both COPD and IPF.
It is possible that alterations in brain function occur beyond the initial anesthetic administration.
It is possible that alterations in the tear lipid layer may lead to an increase in lipid peroxidation.
It is possible that antagonist coactivation also plays a role in age-related weakness , though a definitive link has not been established.
It is possible that bed net use may have maintained this biting profile though this could not be determined unequivocally.
It is possible that better working conditions would result in improved satisfaction with services of all parties involved.
It is possible that cognitive impairment is a clinical feature of frailty and therefore should be included in the frailty definition.
It is possible that combinations of impairments and geriatric characteristics were barriers to the prescription of AVK therapy across the whole of this population.
It is possible that inadequate energy intake is contributing to this condition.
It is possible that in aerobically T subjects , a lower GIP release is partly responsible for a lower postprandial incretin stimulated insulin secretion.
It is possible that long-term caloric restriction partially retards cardiac senescence by attenuating oxidative damage in the aged heart.
It is possible that L / Z status may be more strongly related to cognition when individuals are considered with established onset of cognitive decline.
It is possible that men have more frequently hypertension and glucose intolerance than women.
It is possible that novelty emerged because sophisticated student samples evaluated emotion terms on emotion features.
It is possible that orthopaedic procedures may be among the most cost-effective medical treatments for the aging population.
It is possible that pineal gland can express unidentified signal molecule controlling the expression of AIF and CGRP.
It is possible that strategies to reduce CVD risk may also benefit bone health.
It is possible that such an age-related decrease in stem cells causes impaired regenerative ability and is associated with various skin diseases.
It is possible that the increased cortisol secretion is secondary to peripheral conversion from cortisone.
It is possible that the introduction of exercise in rodents is partly mediated by environmental changes.
It is possible that the life-prolonging effect of caloric restriction is due to decreasing IGF-1 levels.
It is possible that the reduction in HOA is involved in emmetropization.
It is possible that these opposite results are the consequence of using different experimental approaches.
It is possible that these proteins play role in the shared complications of AD and CSMSL including xerosis and itching.
It is possible that the specific multivariate patterns of age-associated changes measured are representative of different types of microstructural pathology.
It is possible that this is the consequence of subclinical changes in cognition in those persons who later develop dementia.
It is possible to establish evidence-based modern stroke treatment within a short time period by a transcontinental on-site and telemedical cooperation.
It is possible to prevent some of the birth injuries by careful obstetric management.
It is predictive of a doubling of the stroke risk.
It is presently unclear as to why older adults take longer than younger adults to recognize visually presented words.
It is presently unclear , however , whether current blood lead levels ( BLLs ) are adversely related to cognitive functioning in older adults.
It is primarily characterized by impairment of memory , associated frequently with mood disorders.
It is principally attributable to dysregulation of the innate immune system.
It is produced in intact endothelial cells by endothelial NO synthase ( eNOS ) as the key enzyme from L-arginine.
It is profoundly accumulated and co-localized with amyloid beta ( Aβ ) plaques in the brain of Alzheimer's disease patients.
It is projected that in the 21st century , the majority of the world's older people will be living in Asia.
It is proposed that ADSCs may improve fibroblast function , but not reverse the age status in vitro.
It is proposed that cationic nanoparticles interact with the cell membrane , triggering membrane disruption and the following Ca ( 2 + ) influx.
It is proposed that these changes produced an unjustified optimism with regard to the prolongation of life.
It is proposed that this set of processes is one plausible candidate for partially mediating the protective effects of cognitive reserve.
It is proposed that γ-PGA incorporation in novel biomaterials has a beneficial impact on future approaches for cartilage regeneration.
It is proposed to concentrate future efforts on elaboration of mathematical models of ontogenetic regulation , on the basis of systems biomedicine.
It is prudent not to offer estrogen therapy to survivors of endometrial stromal sarcoma and women with granulosa cell tumors of the ovaries.
It is questionable whether the view is correct and helpful in the debate on AT use in the care for ( frail ) elderly people.
It is rarely seen in elderly males.
It is reasonable to suspect that the timing of senescence is also influenced by one or more biological clocks.
It is reasonable to use α-Adrenergic Blockers as the treatment of choice for men with hypertension and BPH.
It is recognized that a breadth of product performance tests should be explored to truly identify the effectiveness of antioxidant products for an anti-aging effect.
It is recognized that genetic factors contribute to human longevity.
It is recommended that all randomised controlled trials relating to prolapse surgery include a formal cost analysis.
It is recommended that an assessment of fecal incontinence should be implemented as part of an evaluation of older patients.
It is recommended that future research should test this potentially fruitful hypothesis.
It is recommended that future strategies for redressing age-related associative deficits should take account of the aging brain's increasing reliance on pre-existing semantic associations.
It is recommended that vitamin D supplementation should be implemented in all patients in residential aged care facilities.
It is recommended that , when developing these tools , teams involve people who may ultimately use them.
It is recommended to keep those medications in the lower range of therapeutic doses.
It is recommended to screen individuals with either these comorbid conditions for RLS or the ones with RLS for the accompanying diseases.
It is registered at ClinicalTrials.gov ( NCT02282748 ) .
It is related to biological , functional and psychosocial aging factors.
It is relatively easy to avoid or greatly diminish copper-2 ingestion by not using copper containing supplement pills and testing drinking water for copper levels.
It is reported that approximately @percent@ of residents of aged care facilities fall each year.
It is reported that SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress.
It is reported the case of child whose alopecia started at the age of @number@ months on the occipital region.
It is reported to have various biological actions such as anti-oxidative , anti-inflammatory , and anti-cancer effects.
It is required for the gamma-carboxylation of osteocalcin ( the most abundant noncollagenous protein in bone ) , making osteocalcin functional.
It is revealed that visual impairment may influence the development of mono- and binocular mechanisms of spatial perception and their interaction.
It is sensitive across age groups and is consistent with the subject's overall judgement of the degree to which the environment is facilitating or hindering.
It is shown that component N2 has stability of latency in relation to age and an experimental situation.
It is shown that IGF-1 adsorbs onto the surface of citrate-coated magnetite nanoparticles , and adsorption is confirmed by dot-blot analysis.
It is shown that inclusion heterogeneity in the model is not efficient for large values of heterogeneity variance.
It is shown that incorporating the constraints improves the mean squared error of the estimates and the power of the tests.
It is shown that LIBS could be a promising technique for the analysis of nails and therefore identification of health problems.
It is shown that mitochondria play a critical role in many aspects of life.
It is shown that selectivity can be affected due to the formation or disappearance of endogenous compounds.
It is shown that the crystal structure of apatites depends on changes in the composition of the enamel that happen during a person's life.
It is significantly related to previously defined markers of cardiovascular disease and metabolic syndrome among HIV-infected patients receiving stable antiretroviral therapy.
It is significant that these alterations in the thymus were reduced in FcRγ additionally disrupted Hexb ( - / - ) mice.
It is simple and cheap to administer and requires minimal staff time and training.
It is simple to use and can be adopted as a public health strategy for identifying people with undiagnosed diabetes for early intervention.
It is still a crucial issue to endow Cd-free dual-modal nanoprobes with bright fluorescence as well as high relaxivity.
It is still an open question whether increasing life expectancy as such causes higher health care expenditures ( HCE ) in a population.
It is still not clear as to whether a lack of suppression contributes to hyperglycemia and thus to the development of diabetes.
It is still not clear , however , what the function consequence is of SCN cholinergic neurotransmission.
It is still not commonly used because it is time consuming.
It is still the gold standard , although there are considerable problems related to the underlying assumptions to have reliable readings.
It is still uncertain whether cognitive biases are risk factors for late-life depression.
It is stressed so the importance of a correct clinical diagnosis of the general patient for a better stratification of cardiovascular risk for ophthalmic surgery.
It is striking that all clients , and particularly those with mild-to-moderate cognitive impairment , interact mostly with close relatives and friends.
It is sufficient for the diagnosis of NCSE to be suspected and not strictly confirmed to start preliminary treatment with an antiepileptic drug.
It is suggested by the subanalysis in the existing clinical study with usefulness of bisphosphonates with evidence as an osteoporotic therapeutic drug in life-related disease.
It is suggested here that certain dietary components may either contribute to or ameliorate PD risk.
It is suggested that associative memory tests with multiple trials may be particularly useful for early detection of aMCI.
It is suggested that intervention for frailty requires an interdisciplinary approach.
It is suggested that oxidative processes accompany inflammation and affect their growth.
It is suggested that platelet activation is not derived from aging but from atherosclerosis , although it is difficult to separate aging from coexisting atherosclerosis.
It is suggested that the main pathway used by spermidine to trigger its effects is the MAPK pathway.
It is suggested that this relationship should be further studied in a larger prospective population-based study.
It is suggested that we should pay more attention to increase the coverage rate of HepB among floating children under @number@ years old.
It is supposed that changes in telomere structure eventually expose the chromosome ends to undesired recombination events and thus promote cell senescence.
It is supposed that these characteristics are mostly due to the aging itself.
It is surprising that increasing age and lower global cognition do not appear to influence PA participation.
It is suspected that insufficiency fractures of subtrochanteric femur in patients under long term bisphophonate treatment are caused by severely suppressed bone turnover.
It is suspected that pedestrians are more apt to base their decisions on systematically distorted TTA estimates , rather than physical distance.
It is the case , however , that partial volume effects from free water can bias diffusion measurements.
It is the concept of patient-centred care , including its definition of key components , and efficacy.
It is the current view that the myocardium is an organ permissive of tissue regeneration mediated by exogenous and endogenous progenitor cells.
It is the first demonstration of an age-related neurocognitive improvement in autism.
It is the first report addressing orthodontic tooth movement and microbiological features in a HGPS patient.
It is the first secondary metabolite reported from the species Lecanicillium antillanum.
It is the goal of this study to identify a new set of epigenetic methylation markers for the forensic estimation of human age.
It is the method with an independent future that some earlier writers considered as an aspect of the DCG model.
It is the most common incidental finding on brain scans.
It is the most common symptom in dermatology , and various skin and systemic diseases can be associated with the presence of itching.
It is the most prevalent sensory impairment in the elderly , and may have detrimental effects on their quality of life and psychological well-being.
It is the only declarative memory system that resists so remarkably to the effects of age.
It is the only nationally mandated workforce training program for seniors.
It is the only one of the top ten causes of death in the USA for which prevention strategies have not been developed.
It is therefore a promising tool in the screening for MCI and dementia.
It is therefore biologically plausible that exhaustion / dysfunction of resident lung stem cells contributes to the inability of the immature lung to repair itself.
It is therefore concluded that Gnaq plays a pivotal role in antioxidation in neural cells.
It is therefore concluded that the presentation of tectal plate tumors varies with age.
It is therefore critical to understand how the motor function changes with age.
It is therefore crucial that clinicians can be confident they have obtained a valid estimate of current cognitive functioning.
It is , therefore , crucial to delineate the roles of AD risk factors in cerebrovascular dysfunction.
It is therefore crucial to identify subgroups of patients at risk of pejorative progression in whom prophylactic surgery may be considered.
It is therefore essential to understand the relationship between the ET and the internal carotid artery ( ICA ) from an endoscopic perspective.
It is therefore imperative that undergraduate paramedic attitudes towards elderly patients are investigated , along with pedagogical approaches to maintain or enhance them.
It is therefore important that policymakers and care professionals know how much support this population needs in their daily life.
It is therefore important to consider reduction as a complement to rhytidectomy in selected patients.
It is therefore important to detect and prevent frailty and provide frail elderly people with the adapted care.
It is therefore important to establish priorities for action and individualized therapy , depending on the indications and contraindications for its use.
It is therefore important to evaluate how object recognition performance evolves during the course of adulthood.
It is therefore important to identify factors that influence hematocrit.
It is therefore important to investigate the characteristics of new insulins in this population.
It is therefore important to promote healthy aging in an attempt to favor the preservation of autonomy and functional capacity of the elderly.
It is therefore important to understand the factors associated with sickness absence due to health problems.
It is therefore important to understand which cancers affect them in order to devise better methods to prevent and treat them.
It is therefore likely that any intervention that extends C. elegans lifespan will indicate strategies to positively impact on healthy human longevity.
It is therefore necessary to evaluate preferences at the end of life at an early stage to meet the needs and requests of future patients.
It is therefore necessary to pay particular attention to these clinical issues through appropriate clinical examinations.
It is therefore necessary to understand the mechanism of senescence to design new approaches to combat cancer.
It is therefore not clear whether such molecules have therapeutic potential which highlights the need for further in vivo studies.
It is therefore not required for individuals to be enabled by their employer to be sustainably employable.
It is therefore of great interest to understand the cellular and molecular mechanisms that mediate skeletal muscle development and adaptation.
It is , therefore , possible that differences in age distribution of the samples are one of the reasons for this finding.
It is therefore possible that humans have acquired genetic mutations that mimic the CR effect.
It is therefore recommended that future studies exploring determinants of health and disability in ageing use the COURAGE-derived methodology.
It is therefore recommended that the currently dominating paradigm of \ "aging in place \ " be critically re-evaluated.
It is , therefore , suggested that older adults with childhood food insufficiency might be targeted for programs designed to prevent dementia.
It is therefore surprising that few studies have examined how the related capacity for episodic foresight might also be affected in this age group.
It is the responsibility of the oocyte to continue the BER pathway prior to initiation of S-phase of the first mitotic division.
It is the result of multiple physiologic derangements , ultimately resulting in an insidious functional decline.
It is the second most common cancer among both males and females in Malaysia.
It is the way society moves to understand the value-laden choices on aging that directs the goals of treatment and research.
It is thought that dysfunction of the cortico-basal ganglia circuitry may contribute to age-related sensorimotor impairment , however the underlying mechanisms are poorly characterized.
It is thought that neurotrophins enhance neuromuscular transmission by increasing neurotransmitter release.
It is thought that spine plasticity underlies learning and memory processes , driven by kinases and cytoskeleton protein reorganization.
It is thought that these molecular defects produce a \ "mutator phenotype , \ " which allows incipient cancer cells to accumulate additional cancer-promoting mutations.
It is thought that this transition in cell phenotype causes the shift of the IVD's physical properties , which impede the flow of nutrients.
It is thought to play a role in many cellular processes , including neuroprotection , but may also contribute to Alzheimer's disease and some cancers.
It is thus a good candidate for treatment by pro-apoptotic agents.
It is thus essential to identify the causes of these neuropathies in this group of patients and treat them whenever feasible.
It is thus important that health professionals and others take a holistic approach when dealing with sexual problems in older adults.
It is thus important to gain a better understanding of the most frequent diseases in people living to advanced old age.
It is thus not surprising that mTOR signaling mediates aging and is often deregulated in metabolic disorders , such as obesity , diabetes and cancer.
It is thus potentially a cheap and widely available candidate for prevention programs provided its mechanism may be adequately understood.
It is thus the key to assessment of the level of hypnosis.
It is timely to investigate stability and transition patterns of depressive symptom subtypes.
It is traditionally believed that both familiarity and recollection can support item recognition , whereas only recollection can support associative recognition.
It is traditionally thought to be a disease of young women.
It is traditionally valued and reported for hair-blacking , liver and kidney-tonifying and anti-aging effects as well as low toxicity.
It is true that swaying of telomerase in carcinoma could be facilitated with dedicated set of epigenetic modulators and modifiers players.
It is uncertain how age and residential status affect the accuracy of CURB-65 score in older patients.
It is uncertain whether an age-related PTH increase occurs independent of changes in circulating 25-hydroxyvitamin D , phosphate , renal function , and ionized calcium.
It is uncertain whether the PCSK9 example represents a paradigm or an isolated exception.
It is unclear , however , how well polysomnographic measures of sleep correlate with subjective reports of prior-night sleep quality in elderly men and women.
It is unclear , however , whether a muscle strength ratio can be used to assess age-related , site-specific muscle loss.
It is unclear , however , whether healthy lifestyle behaviors affect the relation between telomere length and CAC.
It is unclear , however , whether such changes begin before the clinical onset of the disease.
It is unclear how GABA mediates these effects.
It is unclear how public health programs can identify the older adults at highest risk of disability related to NCDs within diverse developing country populations.
It is unclear how these processes are impacted by one's age at the time of exposure and the complexity of the DNA lesion.
It is unclear if similar processes occur with healthy aging.
It is unclear if the presence of muscle wasting and fat accumulation in patients with COPD is age or disease-related.
It is unclear if these changes can be prevented or even reversed by systemic therapies administered at advanced age.
It is unclear the contribution of aging on oxidative stress and vascular function in a racially diverse cohort.
It is unclear to what extent these changes are related to alterations in intrinsic LV properties and / or cardiovascular loading conditions.
It is unclear to what extent these degradations exist before symptomatic onset.
It is unclear to what extent these relate to underlying circadian rhythm disturbance ( CRD ) .
It is unclear what the impact is of preoperative therapy with 5-ARI in patients that undergo surgery.
It is unclear whether a graded decrease in cardiac function puts older subjects at risk for brain aging.
It is unclear whether BDNF abnormalities in schizophrenia are specific to gray and / or white matter.
It is unclear whether cancer confers any additional risk for recurrent stroke or cardiovascular mortality after stroke.
It is unclear whether differences are clinically meaningful , although some differences are large.
It is unclear whether interventions can improve depression in those reporting financial strain.
It is unclear whether rare and low-frequency variants in genes implicated by such GWAS confer additional risk of AF.
It is unclear whether repeated exposure to ultra-endurance aerobic exercise is beneficial or detrimental in the long-term and whether it attenuates biological aging.
It is unclear whether repeating a BMD screening test improves fracture risk assessment.
It is unclear whether the decrease in Mito content is consequent to aging per se or to decreased physical activity.
It is unclear whether the risk of stroke after AMI has changed with improvements in treatments and outcomes for AMI in the last decade.
It is unclear whether the same limitation holds in middle income countries , and for both general assessments of health and specific conditions.
It is unclear whether these changes can be generalized to more complex multi-joint movements , where additional sensory feedback may affect performance.
It is unclear whether they modulate dementia risk.
It is unclear whether zirconia crowns require surface treatment to enhance their retention.
It is unclear which component contributes to the decline in PAL performance associated with age effects.
It is unclear which interventions are most appropriate.
It is unclear which of four popular contemporary diet patterns is best for weight maintenance among postmenopausal women.
It is unknown how BP associates with muscle function in oldest old people.
It is unknown however , what leads to a DC for patients fed orally.
It is unknown how frequently PSAVs of this magnitude occur in community men.
It is unknown if habitual attention , involving incidental probabilistic learning , is preserved in older adults.
It is unknown if taxing working memory while walking influences gait performance as assessed by DFA.
It is unknown to what extent cellular immune responses contribute to liver disease and control of viral replication in HDV infection.
It is unknown whether age at diagnosis affects the severity of Rheumatoid Arthritis ( RA ) , we therefore performed the present study.
It is unknown whether age influences the relationship between alcohol intake and the prevalence of metabolic syndrome.
It is unknown whether endurance training ( Tr ) can prevent these changes.
It is unknown whether in addition to their ' core ' cell cycle functions , E-type cyclins also perform unique tissue-specific roles.
It is unknown whether metabolic profiles provide prognostic value better than Gal-3.
It is unknown whether participants in transplant clinical trials-which generate the best evidence for patient care-are representative of the aging population of KTRs.
It is unknown whether patients with MCI and MTL amnesia will be able to use a retrocue to benefit their memory.
It is unknown whether similar changes occur in cardiac muscle.
It is unknown whether such activity also occurs in patients with EGFR gene overexpression , regardless of mutation status.
It is urgent to develop new therapeutic approaches for the treatment of these diseases.
It is urgent to improve integrated strategies to detect , prevent and control HEV infection in dogs and humans exposed to dogs in this area.
It is very important to evaluate the safety aspects and appropriate use of medications in this population.
It is very important to transfer the knowledge and positive habits of proper sun protection to children.
It is very usual finding in cleft palate population.
It is weakly expressed in most adult tissues.
It is well documented that increasing effort during exercise is characterized by an increase in electromyographic activity of the relevant muscles.
It is well established that aging is associated with declines in episodic memory.
It is well established that emotion recognition of facial expressions declines with age , but evidence for age-related differences in vocal emotions is more limited.
It is well established that genotype plays an important role in the ageing process.
It is well established that human brain white matter structure changes with aging , but the timescale and spatial distribution of this change remain uncertain.
It is well established that melatonin ( MLT ) and its metabolites are able to function as endogenous free-radical scavengers and broadspectrum antioxidants.
It is well established that oligodendrocyte generation and the addition of new myelin internodes continue throughout normal adulthood.
It is well established that patients with heart failure are at a greater risk for dementia.
It is well-established that psychological stress plays an integral role in depression and that depression has numerous negative health outcomes.
It is well established that Rb function is largely regulated by a dynamic balance of phosphorylation and dephosphorylation.
It is well established that somatic point mutations accumulate in mtDNA of multiple organs and tissues with increasing age and heteroplasmy is universal in mammals.
It is well established that the cholesterol-transporter apolipoprotein ε ( APOE ) genotype is associated with the risk of developing neurodegenerative diseases.
It is well established that the risk to develop neurodegenerative disorders increases with chronological aging.
It is well established that wound healing slows with age.
It is well known that age modulates cardiac function at the level of the individual cardiomyocyte.
It is well-known that aging is the most risk factor for Alzheimer's disease ( AD ) .
It is well known that ankle joint power generation ( A2 ) is reduced in healthy older adults ( OG ) during gait.
It is well known that biomaterials play an important role in the regulation of adhesion and growth of a variety of cultured cell types.
It is well known that endurance exercise improves mitochondrial function , especially in the elderly.
It is well known that mitochondria regulate aging and lifespan.
It is well known that mutant p53 plays an important role in tumorigenesis and tumor development.
It is well-known that oxidative stress and inflammatory processes are linked to the incidence of atrial fibrillation ( AF ) .
It is well-known that policosanol can improve serum lipid profiles , although the physiological mechanism is still unknown.
It is well known that subcortical nuclei have structural connections to the entire cortex.
It is well known that the number of dividing cells in an organism decreases with age.
It is well known that the onset of essential hypertension occurs earlier in men than women.
It is well known that the quantity and quality of physiological sleep changes across age.
It is well known that the reflected pressure wave in small children returns earlier than that in adolescent.
It is well known that there is a continuous tendency for functional results to improve as the frequency of walking increases.
It is well known that timely treatment of sepsis improves outcome and that septic encephalopathy may precede other signs and symptoms.
It is well protected against ischaemic stroke , and so there is relatively little neuropsychological data about the consequences of focal lesions.
It is well recognized that numerous bioactive dietary components mediate epigenetic modifications associated with the pathophysiology of several diseases.
It is well suited for physicians , particularly medical residents and fellows in-training , who provide care for medically complicated elderly and terminally ill individuals.
It is well tolerated , as effective as NASHA in correction of nasolabial folds , and persistent.
It is widely accepted , however , that differences between normal and POAG TM tissues are presumably a consequence of cellular dysfunction.
It is widely accepted that abnormal accumulation of vascular smooth muscle cells ( VSMCs ) may promote atherosclerosis and post-angioplasty restenosis.
It is widely accepted that age-related changes in lens stiffness are significant for the development of presbyopia.
It is widely accepted that delirium is associated with dementia but the degree of causation within this relationship is unclear.
It is widely accepted that hearing loss increases markedly with age , beginning in the fourth decade ISO @number@ ( @number@ ) .
It is widely accepted that the brain and the immune system continuously interact during normal as well as pathological functioning.
It is widely applied in assessing disease mechanisms and in drug discovery research.
It is widely assumed that older adults suffer a deficit in the psychological processes that underlie remembering of contextual or source information.
It is widely believed that endometrial atrophy in postmenopausal women is due to an age-related reduction in estrogen level.
It is widely believed that language function tends to show little age-related performance decline.
It is widely considered to be a nongenetic disorder , but accumulating evidence suggests that several genes are linked to MSA.
It is widely regarded that chronic inflammation may be a common link in all these age-related diseases.
It is widely used for the treatment of liver diseases in clinical practice.
It is worth mentioning that the therapeutic effects of these drugs are influenced by the apolipoprotein E ( APOE ) -ε4 genotype.
It is worth mentioning that under some physiological circumstances such as normal aging there is a significant decrease in hippocampal neurogenesis.
It later becomes disrupted as a consequence of vascularization.
It leads to damage of many biological structures , resulting in impairment of many processes at the molecular level.
It leads to faster extinction of postmitotic populations which can be a reason for life expectancy reduction of multicellular organisms.
It leads to oxidative changes in human red blood cells ( RBCs ) in vivo and in vitro.
It leads to unspecific symptoms and neurological deficits and is usually treated surgically.
It mainly functions as an oxidative metabolite of choline by suppressing superoxide-induced free radicals by donating methyl groups.
It mainly interacts with RNA via its second and third RNA recognition motifs ( RRMs ) , with specificity for U-rich sequences directed by RRM2.
It makes obvious that the stochastic mechanism of aging is incorrect.
It may also be a significant predictor for men but the sample size is small.
It may also have synergistic effects when combined with pharmacological interventions , again facilitating neurogenesis.
It may also help in providing advice for patients on safety issues.
It may also increase the accuracy of material placement.
It may also reduce the effectiveness of most antihypertensive drugs.
It may attribute to low baseline viral loads and extraordinarily rapid suppression of HCV after treatment day1.
It may be a correlate of the rate of breast tissue aging , as proposed by Pike to explain breast cancer age-incidence.
It may be additionally accelerated by various conditions , including osteoarthritis ( OA ) .
It may be associated with an autoimmune abnormality or be related to aging ( immunosenescence ) .
It may be associated with other rejuvenation techniques such as fillers and botulinum toxin within certain time limits.
It may be concluded that deficits in olfactory identification occur in AD and may be valuable as an indicator of this condition.
It may be concluded that there is a correlation between aging and morphological changes in the mesial root canals of mandibular first molars.
It may be either inherited or may reflect external , environmental factors.
It may be especially important to target those with lower levels of physical activity , poorer physical fitness , and multiple comorbidities.
It may be evaluated with the dichotic listening ( DL ) test , a widely-used experimental paradigm for studying inter-hemispheric interactions and attentional processes.
It may be , however , that modifiable lifestyle factors may indirectly impact sleep by influencing health status.
It may be important to manipulate the level of the speed-accuracy trade-off to improve efficiency and safety.
It may be necessary to assess and manage the sex hormone deficiency in women with age-related macular degeneration.
It may be necessary to search for such tools in large laboratory animals and in human tissue cultures obtained through genetic engineering or cloning.
It may be possible to further investigate the relationship between aging , mutations , and cancer using this approach.
It may be possible to increase the prevalence by intervention directed toward more exercise , non-smoking , and better satisfaction with life.
It may be related to the functional state of the brain.
It may be that the pleiotropic role of biologically active 25 ( OH ) D influences pain and pain processing through peripheral and central mechanisms.
It may be valuable in revealing geriatric problems but current evidence for its usefulness to guide treatment decisions in this setting is limited.
It may develop concomitantly to many aging-related diseases , including arterial hypertension , and exerts detrimental effects on both their outcomes and treatment compliance.
It may explain why larger effects are observed for the shorter durations of exercise while much smaller effects are found after longer periods of exercise.
It may help design future interventional studies , which might be common with other age-related disorders , because of common nutritional factors.
It may help to achieve a better understanding of the disease.
It may help to identify new targets for treatment of diabetes and metabolic syndrome.
It may increase the risk of AMD , but it can also reduce the risk of life-threatening conditions.
It may provide a missing link in the developmental regulation of energy metabolism.
It may reflect a fundamental organizational principle of the olfactory system , which is more \ "error-prone \ " than other sensory systems.
It may represent a potential new therapy for SCI.
It may result from a failure to regulate energy intake and expenditure after periods of underfeeding.
It may result in an impairment of the function and quality of life of these patients.
It may result in erectile dysfunction and decreased libido.
It may take at least three to six weeks to notice any clinical improvement in symptoms.
It meant immense gratitude , but also a sense of dependency on paid caregivers.
It measures transit time between R-ECG and finger or toe pulse signal ( ttf or ttt respectively ) .
It might be important that the evaluation of OH by HUT should be included in daily geriatric practice.
It might be supposed that such a new and original approach could be valuable in cardiovascular prevention.
It might however affect the function of the immune system and , therefore , aging individuals can profit from interventions increasing the level of SIRT1.
It might play a prominent role in the dedifferentiation process occurring when well-differentiated liposarcoma progress to dedifferentiated liposarcoma.
It models the morphological and developmental variability across the population.
It mostly affects aging women and is usually precipitated by emotional or physical stress.
It must centrally value local knowledge and initiatives.
It must therefore avoid the most frequent sequelae , such as the ICC , arrhythmias and hypertensive crises.
It needs to be differentiated from various genetic hypomelanotic hair disorders.
It notes that age , per se , is not a contributory factor in intentionally non-adherent behaviours.
It occurs during aging but is accelerated and pronounced in patients with diabetes mellitus , chronic kidney disease ( CKD ) and established cardiovascular disease.
It occurs in a wide variety of pulmonary diseases and typically originates from the bronchial arteries.
It occurs most commonly in otherwise healthy women during pregnancy or the postpartum period.
It occurs worldwide and affects all ethnic groups.
It offers a summary of key personal characteristics , providing perspective on an individual's life course.
It offers free painting courses to elderly persons referred by local community health centers or community organizations as seniors with psychosocial needs.
It outlines the aging trends in both countries and assesses the level of training for those who provide care in a variety of fields.
It outlines the aims of modern cataract surgery and discusses the main surgical approaches.
It permits cutaneous resurfacing , improving the tone and quality of the skin ( wrinkles and enlarged pores ) , and delicately reshaping facial volumes.
It permits to store excessive calories and to release them if required , using inflammatory cells to remove the debris.
It plays a crucial role in higher cognitive processes and is an endophenotype for several disorders.
It plays an adaptive role in the heart at baseline , thereby maintaining cardiac structure and function and inhibiting age-related cardiac abnormalities.
It plays a role in adipose metabolism and is associated with an increased risk of metabolic diseases in adulthood.
It plays a role in energy homeostasis and promotes growth and survival.
It plays critical roles in tumorigenesis , cellular aging , and stem cell renewal.
It precedes both behavioral abnormalities and structural changes at the neuromuscular junction ( NMJ ) of mortalin-knockdown larvae that exhibit increased mitochondrial fragmentation.
It predicts delayed smoking cessation and an earlier age of lung cancer diagnosis in this meta-analysis.
It presented a high total phenolic content , and moderate antioxidant properties as determined by ORAC assay.
It presents a high prevalence of comorbidities , such as cognitive decline , which is gaining great clinical relevance in recent years.
It presents findings from a qualitative longitudinal study in England.
It produces reliable and predictable results , with optimal outcomes.
It promotes multiple oncogenic phenotypes , including proliferation , motility , and invasion of cancer cells.
It promotes neurodegeneration , impairs neurogenesis , and can be considered a cause of cognitive impairment and sensory and motor deficits in the elderly.
It proposes that genetic variation in APOE may influence the effect of exercise on depressive symptoms.
It protects the BBB before menopause , but may increase BBB permeability with aging.
It protects the germline and stem cells from senescence by preventing telomere attrition.
It provided a reference for clinical and laboratory studies.
It provides additional curricular recommendations to aid in the progressive augmentation of medical school curricula.
It provides an initial , immediate volume replacement for up to @number@ months followed by longer term correction due to biostimulation , resulting in collagenesis.
It provides an initial support for a resource-based explanation of the relation between subjective age and life satisfaction.
It provides an invaluable and unique evaluation of a person's general health status.
It provides a rationale that supports the use of combination techniques / products for soft-tissue augmentation.
It provides a short overview of interactions between platelets and endothelial cells or immune cells via direct cell contact or soluble factors during atherogenesis.
It provides a wide range of quantitative gait measures that appear to help to identify subclinical gait impairments in older adults.
It provides both a continuous subject specific WMH map reflecting different levels of tissue damage and binary segmentations.
It provides important preclinical support to the neurobiological importance of the thromboxane receptor as an active player in the pathogenesis of AD.
It provides information about reinnervation processes , the number of functional motor units and nerve excitability.
It provides the evidences on appropriate management and key nursing points for dependent elderly.
It provides valuable information for physicians and next of kin about the further course of disease.
It rather seems that certain juvenile stress-induced alterations reflect the system's attempts to maintain homeostasis and thus promote stress resilience.
It reacts with deoxyguanosine in DNA to form adducts.
It redirects funding to higher dependency residents.
It refers to deterioration in RBC quality that is characterized by lethal and sub-lethal , reversible and irreversible defects.
It reflected persistent activation of thrombocytopoiesis as confirmed by the studies of hemostasis.
It regulates a variety of important central and peripheral actions related to circadian rhythms and reproduction.
It regulates the viability of gastric cancer cells , so we examined whether it affects their proliferation and how that might be brought about.
It releases hypothalamic-releasing hormones into the portal capillary bed for transport to the anterior pituitary , which provides further signals to target endocrine systems.
It relies on a generic framework for the comparison of diffusion probabilities on the sphere , sampled from the underlying models.
It remained at almost @percent@ in people aged over @number@ years ( @percent@ ) .
It remained to explain why a low dose of a multivitamin and -mineral supplement cause increased oxidative stress.
It remains a serious public health problem not only in Souf oasis , but also in Algeria and all developing countries.
It remains controversial whether APOE E4 polymorphism is related to cognitive function in general population.
It remains possible that these many small effects might be aggregated in networks of functionally linked genes.
It remains to be demonstrated whether improvement in nutritional status may improve the cognitive function or delay progression to dementia in these patients.
It remains to be determined whether this use of bioactive food components can be done safely.
It remains to be investigated whether medical interventions on vascular risk factors have protective effects against the development and progress of dementia.
It remains to be seen whether the latter will receive wide acceptance in practice.
It remains to be seen whether these individual traits are associated with different neurobiological substrates and clinical characteristics of LLD.
It remains uncertain whether this is specifically caused by loss of ovarian function or aging.
It remains unclear however if BZDs play the same role when considering marital status.
It remains unclear to what degree combination antiretroviral therapy ( ART ) protects against HCV-associated liver failure.
It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself.
It remains unclear whether biofeedback procedures , electrostimulation therapy , or magnetic stimulation therapy can enhance pelvic floor training.
It remains unclear whether fiber intake is independently linked to superior physical performance.
It remains unclear whether impaired cerebral vasomotor reactivity also reflects more systemic vascular damage.
It remains unclear whether kidney transplantation favourably impacts VC in the long-term.
It remains unclear whether men show similar life history strategy in shape.
It remains unclear whether postoperative cognitive decline in the elderly is related more to perioperative stress and related medical co-morbidities.
It remains unclear whether this relationship exists for the quadriceps in elderly and young subjects when using single and doublet stimulation.
It remains unclear whether treatment effects persist after discontinuation of the NT-proBNP-guided treatment strategy.
It remains unknown however , whether ESR polymorphisms are associated with the risk of decline in specific domains of cognitive function.
It remains unknown , however , which characteristics should be included in such an assessment instrument aiming to reliably predict adverse anticholinergic outcomes.
It remains unknown if this hormonal abnormality is a cause or an effect of the psychiatric conditions.
It remains unknown whether age determines not only patients ' functional impairments but also the rehabilitation outcome and the required amount of treatment.
It remains unknown whether individuals with AD also develop seeding activity prior to accumulation of phospho-tau.
It remains unknown whether liver fibrosis stage influences the CHF risk or if HIV or hepatitis C virus ( HCV ) infection modifies this association.
It remains unknown whether referral patterns for high-risk surgery have changed as a result and how operative mortality has been affected.
It remains unknown whether SSH1 is activated by soluble ( low-level polymerized ) actin filaments in the cytoplasm.
It reported a prevalence of affected subjects ranging between @number@ and @number@.8 / 100 , 000 in some restricted areas of Northern Italy.
It represents an important example for diversity in BMI-functionality relationship.
It represents a universal evolution in life.
It represents the second leading cause of death and a major cause of disability worldwide.
It requires a static posturography to assess postural control of children with the same handedness and footedness.
It requires prompt and accurate diagnosis.
It restores facial volume , resulting in a more youthful appearance.
It results clear that all the existent knowledge implicates RGN in the control of the main biological processes actually recognized as the hallmarks of cancer.
It results from a forward projection of the gravity due to a sagittal disturbance and a pelvic compensatory backward rotation.
It results in an increased vulnerability to stressors for decreased physiological reserves.
It results in ER homeostasis restoration or in cell death.
It revealed links between the upstream genetic variations and downstream endo-phenotype and suggested several genes with higher priority.
It reveals that the over-expression of alternative and terminal pathway components is significantly involved in human glomerulosclerosis seen in distinct renal diseases.
It reviews the evidence for factors that place older adults at risk for suicide , or protect them from it.
It reviews the pathophysiology , psychiatric manifestations , clinical and imaging correlations of the many causes and types of encephalopathy.
Its aberrant expression has been linked to cancer , neurodegeneration , neuropsychiatric disorders and primary hypogonadism.
Its ability to behave therapeutically as a component of red wine has attracted wide attention.
Its ability to discriminate pain from non-pain-related states was compared with that of preexisting pain assessment tools using archival data.
Its absorption process is complex and highly regulated at the transcriptional , translational and systemic levels.
Its action mechanisms involve the reduction of IκBζ expression and NF-κB p65 activation.
Its adoption would facilitate translation , since it would shift the emphasis to medical practice , particularly the introduction of preventative approaches.
Its advantage of reproducibility , with little disparity among institutions , has opened up the way for multi-center joint studies.
Its adverse associations in affluent modern populations with later onset diseases of aging further characterize APOE-ε4 as an example of antagonistic pleiotropy.
Its adverse effect profile also appears acceptable.
Its adverse-event rate is low and comparable to other statins.
Its age-related characteristics have been studied in women in western countries , but whether these associations apply to women worldwide is not known.
Its agonism by PP decreases somatostatin secretion from human islets.
Its amplitude correlated with short-term memory capacity , but was independent of sensory gating in healthy elderly controls.
Its application may help to evaluate and improve the quality of colonoscopy in population-based colorectal cancer screening programs.
Its assessment by standard questionnaires , which ask participants to reflect on idiosyncratic past painful experiences , is important.
Its awareness has a direct influence on control through drug adherence.
Its beneficial effects in the elderly population , however , are not well-defined.
Its broad relevance and the high connectivity to diverse signaling pathways require a tight control of NF-κB activity.
Its causes are multifactorial but are prominently related to both biologic and social factors.
Its cellular trafficking is tightly controlled as it recycles between endosomes and trans-Golgi network.
Its characteristic appearance is a combination of poor landmark recognition and defective directional guidance.
Its characteristics offer some advantages over them , with potential utility in research and clinical practice.
Its clinical effect is clear.
Its close proximity with the anterior incisors affects one's ability to place immediate implants in ideal position.
Its concordance index ( standard error ) was @number@ ( @number@ ) and @number@ ( @number@ ) in the derivation and validation datasets , respectively.
Its contribution to dysphagia and the effects of healthy ageing require further investigation.
Its correlation with another age-related degenerative process , impaired cognition , remains uncertain.
Its cytotoxic effects , which were observed after treating MSCs with high doses of R-SFN , could be attributed to its HDAC inhibitory activity.
Its deficiency in mice activates cell death programs and premature senescence.
Its development is predominantly based on characteristics which are inherent to the various age phases of life.
Its downstream clinical consequences are still to be learned.
Its downstream p53 was inhibited , and FOXO pathway was activated , indicating that SIRT1 may play a protective role in ARC formation.
Its duration in the time of this study was @number@ + / - @number@ y. ; respectively @number@ + / - @number@ y.
Its economic burden in this context is unclear , too.
It secretes microvesicles called exosomes from the endosomal multivesicular body , which , after mating , fuse with sperm.
It seeks to identify configurations of these homes by seeking shortcomings and / or successful solutions.
It seemed that p38 and JNK MAPK signal pathways are involved in the regulation of the protective function of phlorizin.
It seemed that the extracellular matrix ( ECM ) proteins adsorbed onto the EVAL surface might have a protective role in the cellular aging process.
It seems logical , therefore , to begin by treating these conditions before testosterone replacement therapy is initiated.
It seems possible that compensatory covert saccades could be responsible for improved DVA.
It seems prudent to identify individuals at a high risk of falling and to propose an adequate treatment for them.
It seems that autologous ASCs have great promise for applications in repair of skin , rejuvenation of aging skin and aging-related skin lesions.
It seems that CZr is more reliable parameter than the others to discriminate the physically disabled patients than the healthy persons.
It seems that hyperglycemia is not an important risk factor for future diabetes.
It seems that hypertension of the elderly has a higher occurrence in the case of female patients , due to the lack of hormonal protection.
It seems that in aged people the accommodation capability of the autonomic nervous system is different from that in middle-aged people.
It seems that mild , soluble , Beta-amyloid accumulation can lead to a reduced membrane ( functional ) and an elevated cytosolic GRK2 / 5.
It seems that under chronic stress conditions , however , Lon levels actually decline.
It seems that visfatin / NAMPT plays a role in the pathogenesis of arterial hypertension.
It seems their role as a connector among all pharmacists will be more important.
It seems therefore wise to include them in the decision making processes that lead up to policy changes.
It seems to be particularly important for the weakest to enhance their levels of muscular strength in order to reduce the risk of dying early.
It seems to exert an anti-inflammatory and anti-oxidative stress effect on irradiated keratinocytes that in turn reduces MMP1 expression in dermal fibroblasts.
Its effect on mortality is also assessed.
Its effect on the initial stages of leukoaraiosis is minimal.
Its effects are mainly mediated by stimulating collagen synthesis in dermal fibroblasts and increasing angiogenesis.
Its effects on uptake and adherence of prescribed drugs should be similar across the population , except perhaps in older , less numerate individuals.
Its effects thus reach beyond the housekeeping pathways of protein folding into regulation of a wide range of cellular processes.
It selectively accumulated and rapidly exchanged at a subset of nucleoids distinguished by the presence of newly synthesized RNA and / or mitochondrial RNA polymerase.
Its etiology , biological impact on hematopoiesis , and oncogenic risk is poorly defined at this time.
Its etiology is multifactorial and includes genetic predisposition , obesity and aging.
Its expression appears to decline during aging which could partially explain the build up of damaged proteins in old age.
Its expression is increased expression in neurons and has a specific association with axonal microtubules.
Its expression strongly correlates with aging-associated neurodegenerative and metabolic diseases.
Its feasibility was verified on self-made silicone phantoms by comparing with the mechanical indentation method.
Its findings suggest that active terpenoids from the herb could be used as lead anti-inflammatory agents.
Its formation was followed up from the age of @number@ year till 3-5 years.
Its frequency increases with age.
Its functional role in neuronal migration underlying bilateral symmetry and lateralization of neuronal function further suggests a role in the evolution of human language ability.
Its hallmark feature is kinetic tremor.
Its hallmark is weakness that worsens with activity.
Its hallmark neuropathological features are the presence of amyloid-beta oligomers and neurofibrillary tangles that are composed of hyperphosphorylated tau protein.
It shares these receptors with the closely related TNF family member , B-cell activating factor ( BAFF ) .
Its high incidence in the general population and debilitating symptoms has recently put it at the forefront of mood disorder research.
It should be clarified in the future if autophagy observed is a consequence versus a cause of the degeneration in vivo.
It should be emphasized that several questions related to the details of NVL regime should be specified in further research in the field.
It should be examined in youth with elevated BMI and / or hypertension.
It should be necessary as far as possible to avoid them , especially if treatments are illogical.
It should be noted that the demand for temporal rejuvenation is increasing and precedes the demand of cervicofacial rejuvenation.
It should be noted that this anthropometric measure is a poor instrument since it cannot distinguish between subcutaneous and visceral fat.
It should be recognized that children are not small adults , hence dosing in children should not be a ' small adult dose'.
It should therefore be possible to estimate quantitatively the smoothness of face-to-face communication in social networks through measurement of the synchronization of body movements.
It showed how repartnering in old age changed the family structure , constructing complex stepfamilies , which require further study.
It showed no statistical difference among three remedies ( P > @number@ ) .
It showed that the incidence and mortality of lung cancer in people over @number@ years were increased in the past @number@ years.
It showed very good repeatability.
It shows proto-oncogenic as well as pro-apoptotic properties.
It shows that these meta-analyses on psychotropic drugs have a small impact on prescribing habits.
It shows the importance of the CSFP for the physiology of the eye.
Its imaging appearance depends on the responsible organism , most commonly Streptococcus pneumoniae.
Its imaging patterns vary depending on CD4 count.
Its impact especially on temporal neocortex is associated with impaired neuropsychological function.
Its impairment in many neurodegenerative conditions appears likely to contribute to pathogenesis.
Its importance is demonstrated by large scale to treat kinds of diseases in eastern Asian countries.
Its incidence increases dramatically with the age of women.
Its incidence is 1-4 per @number@ million newborns.
Its incidence is expected to rise because of the age-related incidence of atrial fibrillation and an aging population.
Its incidence is expected to rise in the coming years due to an increasing aging population.
Its incidence is particularly high in people with overt or un ( der ) diagnosed psychiatric disorders.
Its incidence is unknown.
Its incidence may be underestimated.
Its induction of hyperactivity may be the mechanism by which eTau regulates Aβ production.
Its inhibitory activity was confirmed using chromatin immunoprecipitation assay and in situ proximate ligation assay.
Its initiation is defined by a 12-month amenorrhea following the ultimate menstrual period.
Its integration in the context of the continuous improvement cycle is transferable to other contexts in which implementation depth and time are important.
Its levels are lower in sCJD brains than in control brains.
Its localization was confined to neurons.
Its localization within the endostatin domain implicates a functional relevance of endostatin in KS.
Its low levels correlate with increased cardiovascular disease and all-cause mortality.
Its macroscopic as well as microscopic structures change during development , aging , and disease progression as well as following physical or mental training.
Its main constituents are hyaluronic acid ( HA ) and γ-globulin , acting as boundary lubricants for articular cartilage.
Its management will include PDE-5 which are generally well tolerated.
Its mechanism of action gives it a special place among other injectable materials.
Its mechanism of realization is carried out due to hyperactivation of the right hemisphere and it is incorporated on preclinical stage.
Its mechanisms of action are just beginning to be understood.
Its mission is to create a positive experience of painting learning in elderly needing persons.
Its mission is to maximize the cognitive , physical , and psychological recovery of ICU survivors.
Its mission is to reintegrate the patient after surgery back into domestic , social and professional life.
It's more stable than linear RNAs , and would be a useful tool for regulation of gene expression.
Its morphological characteristics and mechanism have been studied in females , but it is unclear whether or not there is a gender difference.
Its most severe stage requires treatment with dialysis.
Its muscularis proper layer consists of muscle cells , connective tissue and myenteric plexus.
It's necessary for us to develop early interventions for middle-aged adults to prevent falls during walking.
Its negative predictive value was high ( ≥79% ) and its positive predictive value was low ( ≤22% ) .
Its objective was to explore how Deaf people's knowledge about dementia and access to services is mediated by their minoritised cultural-linguistic status.
Its occurrence is related to lots of medical and non-medical conditions with uncertain causality.
Its opportunities for the description of risk functions of mortality and life expectancy for the person and animals depending on environment factors are illustrated.
Its paradigms are shifting through time , especially in rapidly developing countries such as China.
Its parameter values and its influence on patellar dislocation are independent of patient age and should therefore be evaluated as in adults.
Its pathogenesis is poorly understood , and therapeutic options are limited.
Its pathogenesis is poorly understood , but both genetic and environmental factors , such as obesity and aging , play a key role.
Its pathogenesis is still undetermined , but may be associated with risk factors such as rheumatoid arthritis ( RA ) .
Its pathogenesis is unknown , may be associated with aging.
Its pathogenesis remains unclear , but mutations in epigenetic modifiers are common and the disease often responds to DNA methylation inhibitors.
Its performance was moderate and comparable with published risk models specifically targeted at new-onset post-isolated CABG AF.
Its persistence in PMW reinforces the important connection between sleep and GnRH secretion.
Its plasma levels were measured in @number@ apparently healthy individuals from @number@ nuclear families.
Its potential benefits in improving social and psychological health suggest the need for a full-scale randomized controlled trial to reveal its empirical effects.
Its predictive ability for all-cause mortality has been sparsely reported , but with conflicting results in different subsets of participants.
Its presence in neuritic plaques in hippocampus is especially relevant , as this is an area closely related to spatial learning and memory.
Its presence is associated with a number of negative outcomes including greater comorbidity and hospitalization.
Its presence places the individual at risk for rapid deterioration when a major event such as myocardial infarction or hospitalization occurs.
Its prevalence increases as person ages.
Its prevalence increases with population aging.
Its prevalence is age dependent , ranging from @percent@ in patients < 50 years of age to @percent@ in those > 70 years of age.
Its prevalence is highly dependent on the setting in which patients are evaluated , ranging from as low as @percent@ to nearly @percent@.
Its prevalence is increasing over the years since the cardiovascular management of patients is improving , and the Western population is aging.
Its prevention is , therefore , critical to impede the transition to overt disability.
Its primary function , to deposit the histone mark H3K27me3 , promotes transcriptional repression.
Its prognostic validity was investigated in the Longitudinal Urban Cohort Ageing Study ( LUCAS ) .
Its properties make it a valuable tool for the assessment of cognitive-affective processes that are involved in feedback and reward processing.
Its protein stability is regulated by ubiquitination and proteasomal degradation , mainly mediated by Mdm2.
Its psychometric properties support it as a sound instrument for measuring reminiscence functions among Chinese older adults.
Its purpose is to improve functional ability in daily occupations ( everyday activities ) perceived as important by the older person.
Its quality , as well as the causes of visual acuity < 20 / 60 and the barriers to accessing surgical treatment were assessed.
Its regulation relies on the delicate balance between activating kinases and suppressing phosphatases and is still not very well understood.
Its relevance with the immediate post-operative phase was made clear.
Its results may give answers to the possible benefits and risks of testosterone replacement in aging males.
Its results may yield public health insights that are actionable and improve the quality of life of older adults.
Its role as a potential biomarker of cognitive function deserves further study.
Its screening is extremely important because within a year in 15-20% of cases dementia can evolve.
Its sensitivity was @percent@ and its specificity was @percent@.
Its severity reduces patient recovery , independence and quality of life.
Its significance lies in its ability to support the retina mechanically and metabolically.
Its specificity is primarily supported by cognitive-experimental and neuroimaging research , but recently also from an individual differences perspective.
Its supplementation increases lifespan and resistance to stress , and decreases the occurrence of age-related pathology and loss of locomotor ability.
Its target site is the inner mitochondrial membrane ( IMM ) of each cell.
It stayed in that area through the 60 + group , offering more ribcage protection.
Its treatment is usually surgical.
It suggests an increase in choroidal volume up to the age of @number@ years.
It suggests that architecture through location and spatial features needs to generate positive associations with the users.
It suggests that more effective treatments of persistent pain and depression would provide the largest HRQOL benefit.
It suggests that there are different mechanisms for memorizing pictures with and without human contexts in older adults.
It suggests the existence of specific telomere stabilizing factors in the cortex cells.
Its ultimate cause ( s ) is ( are ) unknown.
It summarizes gaps in the assessment , outcomes measurement , and treatment of these diseases in this unique population.
It summarizes the latest epidemiological findings with an emphasis on age- and sex-related differences.
It supports multidisciplinary action for prevention , promotion , and treatment of the elderly population's oral functions.
It supports the need for using ultrasound-guided techniques for IJV cannulation following LMA insertion in spontaneously breathing children.
It suppresses the accumulation of mutations in somatic cells and substantially decreases the probability of malignant diseases.
Its usage its not only regulated in a position paper of the German Society of Cardiology giving detailed recommendations for its application and indication.
Its use has grown further since its FDA approval in @number@ for long-lasting correction of moderate to severe wrinkles and folds.
Its use in children is generally not accepted because of nonspecificity at this age.
Its use inclines more towards anti-aging and natural rejuvenation of the face , neck and neckline.
Its use in this group should therefore be discouraged.
Its use may allay concerns about the risk of bradyarrhythmia and facilitate a more widespread use of β-blockers in this context.
Its utility lies in MBI case detection , and monitoring the emergence of MBI symptoms and domains over time.
Its validation requires further research involving the lifetime risk of cancer in patients with and without hernia.
Its validity relative to the maximal force exerted during the EPU is modest.
Its validity was calculated using generalizability theory , which enables different sources of error affecting a behavioral measurement to be analyzed jointly.
Its validity was evaluated by examining associations of physical demands and iso-strain ( combination of high psychosocial demands and low resources ) with health.
Its value was described own for each individual and unchanged during adulthood.
Its volatile signature can be used in search exercises to locate injured or deceased individuals.
It's well known that IL-22 is a pro-inflammatory cytokine produced by activated T lymphocytes and NK cells.
It takes about @number@ minutes to carry out and provides a quick overview of the patient's cognitive profile.
It takes only several minutes to complete , comprising @number@ trials for each subject.
It targets people over @number@ years who require needs assessment for access to long term publicly funded services.
It thereby provides a basis for understanding competent emotion regulation , the well-being paradox , and emotionally critical periods.
It therefore becomes significant to determine whether Rb protein is necessary in HMGA2-induced SAHF formation.
It therefore indicates the importance of an appropriate , contextualized framework to support multiple concomitant quality improvement processes.
It therefore should be provided intravenously to all patients who require parenteral nutrition ( PN ) .
It thickened during childhood and adolescence.
It thus appears as if individual differences in subjective memory assessments hardly reflect individual differences in memory in old age.
It thus maybe , that especially the younger participants ' performance deteriorated due to the monotonous nature of the task itself.
It thus remains unclear how motor learning is influenced by cerebellar diseases or aging , and is related with incoordination.
It took them an average of approximately @number@ minutes to do so.
It typically addresses the issue of normality / abnormality of an individual's performance.
It typically occurs on areas of chronic UV exposure , including the face , ears , and neck.
It undergoes structural change in aging and is sensitive to neurodegenerative and psychiatric diseases.
It underscores the importance of social work inclusion in integrated health care delivery and offers recommendations for practice education.
It upholds the use of previously published histological aging charts for LEHs on anterior teeth.
It used a subsample of the Aging , Demographics , and Memory Study ( N = @number@ ) .
IT use for personal tasks was negatively associated with formal social participation for older adults.
It uses abilities of the different plant cells to dedifferentiation into stem cells and coming back to the pluripotent status.
It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system.
It uses healthcare and media literature to compare their use of realism and assess their likely effect on public awareness.
It usually occurs between the ages of @number@ and @number@ years , and is associated with hormonal , physical , and psychological changes.
It varied in its content , frequency of administration and duration.
It was a cross sectional population study of people aged @number@ years or more where @number@ respondents were interviewed in @number@
It was agreed that BACKGROUND : Oxidative stress is a major aetiological factor driving chronic obstructive pulmonary disease ( COPD ) .
It was already demonstrated earlier that the cytosolic proteasomal system declines dramatically with aging , whereas the nuclear proteasome remains less affected.
It was also an independent prognostic factor of overall survival in patients with TGCT.
It was also evident that 5-aza-induced senescence mirrors natural replicative senescence due to telomere shortening.
It was also examined whether explicit learning in older adults can be promoted by alleviating time constraints during learning.
It was also found a low to little correlation between scapular position and age.
It was also found that expression of tau40 promoted microglial migration and phagocytosis , but not proliferation.
It was also found that patients may not be aware of support services available in the community.
It was also found that PKCβ can phosphorylate FTO on threonine , and this phosphorylation requires both catalytic and regulatory domains of PKCβ.
It was also hypothesized that vitamin E concentrations shortly after hip fracture would be lower than those in nonfracture controls after adjustment for covariates.
It was also identified as a candidate gene that affects lifespan.
It was also inversely correlated to the axial length ( r = @number@ P = @number@ ) .
It was also possible to infer that this improvement occurred regardless of the environment , i.e. aquatic or non-aquatic.
It was also shown that cholesterol was to a large degree excluded from trapped lipid domains in cortical membranes.
It was also significantly associated with cancer-specific and overall survival ( logrank p = @number@ and p = @number@ respectively ) .
It was analyzed to investigate differences between the two groups.
It was an ambispective study of @number@ patients with urological problems unrelated to sexuality.
It was an analytical study.
It was applied the Quality of Life Swallowing protocol.
It was associated with factors from multiple levels of the International Classification of Functioning , Disability and Health.
It was a well tolerated and minimal invasive procedure that allowed a good respiratory ability and a fast clinical resolution of the laryngeal functional impairment.
It was compared to a cohort of @number@ patients < 70 years ( mean = @number@ years , SE @number@ ) .
It was concluded that breathing , meditation , and posture-based yoga increased overall brain wave activity.
It was concluded that early ageing is under the influence of these genes and the environmental and socio-demographic factors.
It was concluded that in this CKD population concentrations of uraemic toxins did not change substantially with calendar age.
It was concluded that the data suggest that there is no significant change in voiding function related to age.
It was concluded that the prevalence of malocclusion in preschoolers was high and it was associated to the age and school type.
It was concluded that the share of elderly people , weakened in Belo Horizonte was represented by less than one with good health.
It was conducted in the municipality of Tromsø , Norway , from @number@ to @number@
It was decreased in persons with higher serum triglycerides.
It was delivered by telephone and e-mail for cost efficiency and the ability to handle caseloads of @number@ to @number@
It was demonstrated that the change in corneal curvature causes this shift.
It was demonstrated that the MMBF in shoulder region were affected by aging effect and towards lower value at higher pain level.
It was determined that @percent@ of the elderly ADL were completely dependent , @percent@ were semi-dependent.
It was determined whether or not the participant experienced forced sexual contact since the age of @number@
It was developed by an interdisciplinary team including indigenous scholars / researchers , knowledge users and key informants.
It was discovered that the Graph Index Complexity of gamma band is discriminative in distinguishing autistic children from non-autistic children.
It was due to the type of rehabilitation hospital , so higher percentage of neurological patients were included.
It was established that the microbiota composition of the human gut is modulated by lifestyle factors , especially diet.
It was estimated that @percent@ of US military veterans reported pain in the previous @number@ months , with @percent@ classified as having severe pain.
It was estimated that the costs of treating proximal femur fragility fractures in @number@ summed up to @number@ billion Euros.
It was evaluated by a written questionnaire sent to participants.
It was evaluated by focus groups with primary care physicians.
It was expected that goal disengagement capacities would prevent an adverse effect of heightened functional disability on increases in depressive symptoms.
It was first described in @number@ by the German physician Alois Alzheimer.
It was followed by a technical feasibility analysis leading to an iterative process of prototype development , sensor integration , and testing.
It was found that among the women of mature age studied , mesoplastic ( @percent@ ) and stenoplastici ( @percent@ ) somatotypes were dominant.
It was found that asymmetry did not differ over the age range of 52-84 years of age.
It was found that BDS users had better diet quality than DS users as well as nonusers of DS.
It was found that girls and boys differed on four of nine subscales measuring reasons for tanning.
It was found that in treatment of elderly population hypotensive drugs , diuretics and cardiac glycosides are used excessively.
It was found that mosquito control alone would have increased incidence of DF and DHF in areas of high mosquito density.
It was found that OABSS had a very high correlation with aging ( r = 0.75 ; p < 0.001 ) .
It was found that @percent@ of men and @percent@ of women ate together less than once a month.
It was found that periodontal recesses mikrobiocenosis of patients with CGP of various ages was mainly presented by conditionally pathogenic bacterial and fungal microflora.
It was found that pitch perception was particularly impaired in older adults , and that it displayed the strongest correlation with prosodic emotion discrimination.
It was found that pretreatment with mussel oligopeptides could significantly attenuate these properties associated with cellular senescence.
It was found that the axes of refractive astigmatism shift from with-the-rule toward against-the-rule with aging.
It was found that the initial location of the COM was significantly more anterior in the older adults.
It was found that the iron distribution in the adult human brain is quite heterogeneous.
It was found that the need for surgical intervention was higher in men.
It was found that the prevalence of self-neglect was @percent@ for mild self-neglect and @percent@ for moderate to severe self-neglect.
It was found that uMSCs transplantation significantly delayed the development of proteinuria , decreased anti-dsDNA , alleviated renal injury , and prolonged the life span.
It was found that up to @percent@ of the elderly suffer from dementia , and @percent@ to @percent@ from depressive disorder.
It was found that with age , external moral identity motivation decreased , whereas internal moral identity motivation increased.
It was found to have strong internal consistency and split-half reliability as well as allowing for a good replication of the original factorial structure.
It was frequently identified through emotional isolation and social isolation.
It was further reported that HOA increase is associated with deterioration of visual function.
It was highest at T10 at @number@ ± @number@ mm and lowest at L4 at @number@ ± @number@ mm for the entire study population.
It was hypothesised that population studies would produce higher atrophy rates than clinical observational studies.
It was hypothesized that the amyloid protein has prion-like properties.
It was hypothesized that the Elderly would demonstrate higher head angular velocities and greater step latencies than the Young.
It was hypothesized that there would be a positive association among perceived stress , depression , and hypertension mediated by social support.
It was identified that ADSCs promoted proliferation of co-cultured HDFs and induced increased expression of type I collagen and decreased expression of MMP-1.
It was identified that SBGE treatment for @number@ h inhibited MCF-7 proliferation and increased the sub-G1 phase ratio.
It was increasing along with aging ( @percent@ among @number@'s and @percent@ in people over @number@ years old ) .
It was initiated in @number@ with @number@ respondents aged @number@ years or older.
It was in the temporal GCC that more changes were found.
It was mainly 4-5 cm from the angle of the mandible.
It was manifested in this study as a disability-neutral experience.
It was noted that younger men selected emergency rooms more often than young women , with the difference cancelling out as they age.
It was noted to be a safe procedure with no significant adverse events such as scarring.
It was not evident that the conjunctions between gray matter and activation were related to task performance.
It was not observed adverse events.
It was observed that as age increased , elongation of the styloid process increased with a male predominance.
It was observed that the apex deriving from the most distal fused spinous process was at the level of S2 in one of two children.
It was observed that the number of interventions decrease with age.
It was observed that those individuals who accrued more LTM from adolescence to adulthood had significantly greater adult bone structural strength at the hip.
It was observed that waist circumference as well as total and low-density lipoprotein cholesterol levels significantly decreased with training ( P < 0.01 ) .
It was only modified when we included cystatin C levels.
It was only partially explained by physician diagnoses of concomitant mental disorders.
It was @percent@ greater at maximum flexion than quiet standing , @percent@ greater at maximum extension , and @percent@ greater during combined adduction-flexion.
It was positively associated with albumin , serum iron and hemoglobin.
It was possible to detect a novel , previously undescribed , variant in the RYR2 gene.
It was possible to identify variables that predict institutionalization during a subsequent 30-year period , but different analyses revealed different effects from the factors evaluated.
It was possible to obtain a high classification accuracy of @number@
It was possibly attributed to reduced daytime sleepiness and increased activity level.
It was predicted that level of control beliefs would influence misinformation susceptibility and overall memory confidence.
It was predicted that long-term training in t'ai chi and meditation plus exercise would produce greater benefits to executive function than aerobic exercise.
It was predicted that @number@ and @number@ new cases of mesothelioma in men and women , respectively , would occur over the next @number@ years.
It was predicted that older adults would provide more differentiated assessments of the two targets than would younger adults.
It was rarely present without simultaneous chronic comorbidities or kidney damage.
It was recently found that a hexanucleotide repeat expansion in C9ORF72 is its most common cause in these populations.
It was recently hypothesized that age-related differences in selective attention depend on sensory modality.
It was recently shown in cultured-cell models , in particular with fibroblasts , that the frequency of the applied stress is a fundamental stimulating parameter.
It was recently shown to participate in adipogenesis in rodents.
It was reported that a polymorphism in the gene of interleukin-6 ( IL-6 ) was associated with OA of knee.
It was reported that the important age when age-related shrinkage of the hippocampus starts was around the mid-40s.
It was reported to have similar positive effects on the human metabolism as caloric restriction.
It was revealed that Cryab was markedly upregulated in the SN of PD brain.
It was revealed that in normal fibroblasts , terpenes induced genes of stress response , apoptosis regulation and tissue regeneration.
It was revealed that widow discrimination does not prevail across the nation.
It was shown that a decrease of IGF-1R expression caused reduction of both PG levels and cell density in the tissue.
It was shown that aging of the composite had a negative effect on biocompatibility , regardless of the storage condition.
It was shown that all the mentioned features were accompanied by a reduction in telomerase activity and telomere shortening.
It was shown that in children with low vision there is no increase in contribution of binocular mechanisms with aging.
It was shown that long-term treatment with SkQ1 increased the lifespan of plants , fungi , invertebrates , fish , and mammals.
It was shown that low-molecular serum subproteome of healthy humans was characterized by significant inter-individual variability.
It was shown that PlGF enhanced hair shaft elongation in ex vivo hair organ culture.
It was shown that the glandular acini contained thin , elongated cells and cuboidal cells between the mucocytes surrounded by the myoepithelial cells.
It was shown that the protein was glycosylated and assembled into trimers.
It was shown that the ratio of 33 / 55 kDa tau forms in cerebrospinal fluid ( CSF ) was specifically reduced in PSP CSF.
It was significantly greater for the task of judging emotion than in the eyes-matching task.
It was significantly lower in males than in females.
It was suggested that glucose metabolism and body fat content depend on serum levels of 25-hydroxyvitamin D [ 25 ( OH ) D ] .
It was suggested that P-NCP can inhibit photo-aging related to ROS owing to its antioxidant effects.
It was suggested that the active cell density of the connective tissue cells might decrease significantly in the LCF in childhood.
It was suggested that this association might be because of an underlying susceptibility in genes responsible for extracellular matrix ( ECM ) remodeling.
It was tentatively suggested that people with MCI can learn specific information , although there was little evidence to suggest that memory training can generalize.
It was unexpected to find that lower health-literate patients performed more self-care management.
It was verified that @percent@ needed help in one or more ADL and @percent@ in AIDL.
It was well accepted among patients ; however , some questions need further review to improve their comprehensibility.
It were considered as statistically significant the data with P < 0.05.
It will also be helpful to guide the strength of treatment recommendations.
It will also discuss whether age-related changes can be attenuated by dietary protein and exercise in the older population.
It will also review the distinct disease courses and MS variants.
It will also shed light on why certain stereotype threat effects \ "fail to replicate \ " across domains or groups.
It will be beneficial to further identify their biological characteristics.
It will become increasingly important to define risk factors , delineate etiologies , and devise new management strategies for patients with symptomatic shoulder disease.
It will become increasingly important to identify factors that contribute to risk and resilience in this growing population.
It will be important for physicians to understand the molecular basis for the pathology and how it translates to developing clinical treatments for disc degeneration.
It will be important to further establish the intra-individual age- and sex-specific changes in each sphingomyelin species in relation to disease onset and progression.
It will be important to test the validity of these findings in other similar populations in the developing world.
It will build up a new foundation for further study on mechanism and development of better therapeutic agent and healthy product from Anemarrhena asphodeloides.
It will build up a new foundation for further study on Polygonum multiflorum.
It will change in future as well.
It will include all patients undergoing surgery by TURP or Open Prostatectomy in a period of @number@ months.
It will lead to in vitro cell aging that could modify cell properties.
It will provide important clinical implications for future preventive approaches for aging and aging-related degeneration diseases in humans.
It will provide valuable information to inform research procedures in this important but challenging area.
It will recruit patients living with HIV who are aged @number@ years or older or have lived with HIV for @number@ years or more.
It would also be a cause of \ "locomotive syndrome \ ".
It would appear possible for many training programmes to be developed and delivered with minimal cost impacts even within rural localities.
It would appear that for such interventions to be effective , they should be flexible enough to address a variety of specific concerns.
It would appear that more than the random processes of aging drive this effect.
It would be necessary to establish different reference cut-offs according to age , considering the analytical methods used.
It would be necessary to reach a consensus on which diagnostic tools to use if one wishes to have comparable data obtained in epidemiological studies.
It would seem wise therefore to investigate the molecular connections between lifestyle and cognitive decline in more detail.
Iutw% increased gradually before @number@ years old , then decreased after that.
IVA may also be useful for treating patients with ovarian dysfunction including aging women and cancer survivors.
IVCM of the conjunctiva may represent an imaging tool to predict the surgical success in glaucoma.
IVT was administered to @number@ ( @percent@ ) patients with dementia and @number@ ( @percent@ ) patients without dementia.
I will also discuss possible therapeutic strategies to target this Galectin for cancer therapy.
I will then briefly discuss models of aging and propose an experiment that would distinguish between those models and provide a basis for organismic rejuvenation.
JAB1 ( C-Jun activation domain-binding protein-1 ) promotes the degradation of the tumor suppressor , p53 , and the cyclin-dependent kinase inhibitor , p27.
Jacobian integration could be useful for measuring GM atrophy rate in Alzheimer's disease as a marker of disease progression and treatment efficacy.
J. Acoust.
J. Acoust.
JAHF grants provided the resources to create a cadre of physicians whose research , teaching and practice leads to substantial contributions in geriatrics.
Jails and prisons continue to be potent targets for public health interventions.
James got out of his car , carrying his cane in his hand , and walked with Manor to the lab.
JAMQ would be useful to separately assess individual aspects of somatic , psychological and sexual symptoms related to LOH among Japanese males.
J and H cybrids have significantly altered expression of eight nuclear genes of the alternative complement , inflammation and apoptosis pathways.
Janus-activated kinase ( JAK1 / 2 ) protein expression , which transduces IL-6 signaling , was higher in omental than subcutaneous preadipocytes and WAT.
\ "Japanese clinical practice guidelines for the management of kidney disease in cancer survivors \ "have been published.
Japanese health system has been evaluated to be the closest to the ideal Universal Health Coverage ( UHC ) in the world.
Japanese subjects exhibited BMD and CT values similar to those reported for US non-Hispanic white women , but had 16-23% smaller SM values.
Japanese women considered events related to marriage , death and grief as the most important life events when compared to Japanese men.
Japan has decided to implement HTA and the provisional phase has started this year.
Japan has laws regulating air pollution levels and providing compensation for victims of pollution-related respiratory disease.
Japan has now become an aging society.
Japan is currently experiencing the most rapid population aging among all OECD countries.
Japan is facing an unprecedented aging society.
Japan leads the global race for solutions to the increasing long-term care demand from an ageing population.
Japan provides a compelling context to test this hypothesis due to its rapidly growing elderly population and the phenomenal health of the population.
Japan's population is aging more rapidly than that of any other country.
Jaques-Dalcroze eurhythmics ( JDE ) is a music-based movement training program that emphasizes multitask coordinated movement.
Jaw opening force was measured three times using a jaw opening force sthenometer ; the mean of these three measurements was used for analysis.
J. Biomech. , @number@ 1119-1126 ) .
J. Cell.
J. Cell.
J. Cell.
J. Cell.
J. Cell.
J. Cell.
J cybrids have altered bioenergetic profiles compared with H cybrids.
J Drugs Dermatol.
J Drugs Dermatol.
J Drugs Dermatol.
J Drugs Dermatol.
Jean Bojko and his TéAtr éPRouvète theatre group go out to meet population.
J. Eng.
J Gerontol A Biol Sci Med Sci.
J Gerontol A Biol Sci Med Sci.
J haplogroup has been associated with high risk for AMD while the H haplogroup is protective.
Jhy is evolutionarily conserved from humans to basal vertebrates , but the predicted JHY protein lacks identifiable functional domains.
Jill turns @number@
\ "Jim \ " Birren , who passed away on @date@ , at the age of @number@
J. Ind.
J. Ind.
( JINS , @number@ @number@ 1005-1015 ) .
( JINS , @number@ @number@ 1-11 ) .
( JINS , @number@ @number@ 1-12 ) .
( JINS , @number@ @number@ 223-238 ) .
( JINS , @number@ @number@ 239-253 ) .
( JINS , @number@ @number@ 332-340 ) .
( JINS , @number@ @number@ 341-351 ) .
( JINS , @number@ @number@ 431-445 ) .
( JINS , @number@ @number@ 481-492 ) .
( JINS , @number@ @number@ 493-501 ) .
( JINS , @number@ @number@ 90-97 ) .
( JINS , @number@ @number@ 978-990 ) .
Jitter was greater for older speakers , and the contact quotient ( Qx ) was significantly lower for older speakers.
J. Med.
( J Neurosci 33 : 12470-12478 , @number@ ) have recently reported that anodal transcranial direct current stimulation ( atDCS ) mitigates age-related cognitive changes.
JNK2 exhibits an opposite activity in the regulation of SIRT1 degradation.
Job characteristics appear to have implications for cognitive ageing independent of relevant confounds.
Job-related stress showed no impact.
Job status and asthma were assessed in biennial ( 1989-2011 ) and asthma-specific questionnaires ( @number@ @number@ ) .
Job strain was unrelated to either moderate or heavy drinking.
Job stress was assessed by the Swedish Demand-Control-Support Questionnaire.
John Cassel's @number@ paper \ "The Contribution of the Social Environment to Host Resistance \ " ( Am J Epidemiol.
John Roberts is an employee of Intercytex.
Johns Hopkins University has been offering medical students a summer experience of mentored research , research training , and clinical shadowing since @number@
Joinpoint regression was performed to obtain estimated annual percentages and Bayesian age-period- cohort modeling was used to predict the incidence rate until the year @number@
Joint assessment of donor-recipient genotype pairs provides more information for prediction of early kidney transplantation outcomes.
Joint associations of smoking and alcohol consumption or BMI with elevated or log-transformed γ-GT were examined by tabulation and multiple adjusted regression models.
Joint coordination was investigated by artificially removing the covariation of each joint's motions with other joints ' motions.
Joint diseases resulting from insufficient or excessive activities are new and major challenging issues with our aging population.
Joint modeling examined relationships among BMI , IIS , and ADNP in the overall sample and stratified by initial visit Clinical Dementia Rating score.
Joint modeling methods have become popular tools to link important features extracted from longitudinal data to a primary event.
Joint morphogenesis involves signaling pathways and growth factors that recur in the adult life with less redundancy to safeguard joint homeostasis.
Joints are susceptible to insufficient or excessive activities , leading to joint degeneration.
Joints on the left and right side of the body were equally affected.
Joints were classified into three grades based on histological observations.
Joints with diarthrodial structure decreased significantly with age relative to all subjects ( P < @number@ ) .
Jorm's mental health literacy framework guided the study theoretically.
J Orthop Sports Phys Ther @number@ ; 46 ( @number@ ) : 1065-1070.
J Orthop Sports Phys Ther @number@ ; 47 ( @number@ ) : 914-922.
Journal entries or response notebooks can highlight reflection upon others ' viewpoints , class readings , and additional materials.
Journaling meshes with transformative learning constructs , allowing for critical self-reflection essential to transformation.
Journal of Aging and Physical Activity , @number@ 127-159 ; Rikli , R. E. , & Jones , C. J. ( 1999a ) .
Journal of Experimental Psychology : Human Perception and Performance , @number@ 1072-1089 , @number@ ] .
[ Journal of Gerontological Nursing , @number@ ( @number@ ) , 23-29. ] .
Journal of Neuroscience Research Published by Wiley Periodicals , Inc.
( Journal of Psychiatric Practice.
( Journal of Psychiatric Practice @number@ @time@ @number@ ) .
[ Journal of Psychosocial Nursing and Mental Health Services , 55 ( @number@ ) , 13-17. ] .
[ Journal of Psychosocial Nursing and Mental Health Services , 55 ( @number@ ) , 27-30. ] .
[ Journal of Psychosocial Nursing and Mental Health Services , 55 ( @number@ ) , 7-10. ] .
J. Parn. & Chantaran.
J. Phys. Anthropol.
J. Phys. Anthropol.
J. Phys. Anthropol.
JPS error was determined by the magnitude of matching errors during vision and no-vision conditions.
J Sex Med @number@ ; 14 : 1046-1058.
J Sex Med @number@ ; 14 : 1104-1115.
J Sex Med @number@ ; 14 : 1116-1124.
J Sex Med @number@ ; 14 : 413-424.
J Sex Med @number@ ; 14 : 425-433.
J Sex Med @number@ ; 14 : 493-501.
J Sex Med @number@ ; 14 : 883-890.
J Sex Med @number@ ; 14 : 918-927.
Judges therefore often call on forensic experts to verify the age of individuals depicted on photographs or videos.
Judgment is widely recognized as an important executive function , and deficits in judgment can lead to health risks , safety concerns , and hospitalizations.
Judicious use of functional neuroimaging tools can advance pathophysiologic models of geriatric depression.
Judicious use of these treatments , alone or in combination , can greatly alter the appearance of the region.
Juglanin also repressed SA-β-gal activity in HDFs under replicative senescence.
Juglanin decreased senescence-associated β-galactosidase activity ( SA-β-gal ) and the level of reactive oxygen species in senescent cells induced by adriamycin treatment.
JunD also enhanced formation of the Drosha microprocessor complex , thus further promoting miR-29b biogenesis.
Jurisdictions interested in attempting their own telehealth program will be interested in the challenges and successes identified during the process.
Just as elders show profound declines in cognitive function , they also show profound declines in choice rationality compared with their younger peers.
Just as in mammals , however , the regulatory realm of AMPK function extends beyond metabolic rates and lipid metabolism.
Just as there are multiple determinants of cancer risk , there are likely multiple solutions.
Just less than half ( @percent@ ) the study population suffered from two or more chronic diseases.
Just like every other part of the organism , the skin ages as a result of the passage of time.
Just more than @percent@ ( @percent@ ; N = @number@ ) of persons with dementia permanently entered a nursing home during the 3-year study period.
Just one study based on a primary care population was described.
Just over half of the group claimed to be in good health , and have no afflictions.
Just over half of the women ( @percent@ ) would not consider the procedure while @percent@ indicated they had no opinion.
Just @percent@ of the GP group agreed with the statement that vascular surgeons treat patients with wounds that do not heal.
Just this has to result in aging because of accumulation of various errors.
Juvederm™ family achieved the best efficacy , while the adverse event incidence for Juvederm™ family was significantly higher than for other HA products.
Juveniles with MetS displayed unchanged levels of vitD as compared to overweight / obese juveniles without MetS.
K2 and SSD significantly decreased with subject's age whereas MTT significantly increased with subject's age.
K36 downregulated the expression of the transcription factor , activator protein-1 ( AP-1 ) .
K6W-Ub is effectively conjugated and deconjugated but the conjugates are not degraded via the ubiquitin proteasome pathways ( UPP ) .
Kaempferol as a flavonoid has antioxidant and anti-tumor properties.
Kaempferol has been shown to induce apoptosis and cell death in cancer cells.
Kangen-karyu counteracted oxidative stress and ameliorated tissue damage possibly associated with aging.
Kangen-karyu showed beneficial effects on type @number@ diabetes and related complications through the suppression of protein expression related to advanced glycation endproducts and oxidative stress.
Kaplan-Meier analyses and Cox proportional hazard models were performed to examine the relationship of frailty with mortality.
Kaplan Meier analyses for survival were @percent@ , @percent@ , and @percent@ at @number@ @number@ and @number@ years , respectively.
Kaplan-Meier analysis showed no significant difference among the study groups ( log-rank test , P = @number@ ) .
Kaplan Meier analysis showed that SDNN and CVRR were useful markers for the longevity of very elderly subjects.
Kaplan-Meier analysis was used to assess survival.
Kaplan-Meier and Cox analyses were conducted to compare the rate of antipsychotic drug use between the rivastigmine and donepezil groups.
Kaplan-Meier and multivariate logistic regression and Cox proportional hazard regression analyses were performed.
Kaplan-Meier and stratified Cox proportional hazard regressions were performed for analyses.
Kaplan-Meier curve demonstrated that the age-adjusted CCI ≥ @number@ had poor prognosis after TMVr.
Kaplan-Meier curves and ROC curves were plotted.
Kaplan-Meier curves showed a cutoff of @number@ mg / dL for IgM and @number@ cells / mm ( @number@ ) for NK cells.
Kaplan-Meier curves were estimated for survival after dementia diagnosis by race / ethnicity.
Kaplan-Meier distributions of discharge differed significantly between participants who had or not the combination of the @number@ criteria ( P < 0.007 ) .
Kaplan-Meier estimated patients with achievement of clinical and biological responses at week @number@ or MH was likely to remain sustained clinical response.
Kaplan-Meier estimates show that the e4 allele carriers live shorter lives than the non-e4 allele carriers ( log rank = @number@ ) .
Kaplan-Meier estimator and Cox proportional hazards model were performed to examine the association between baseline depressive symptoms and future CVD event.
Kaplan-Meier log-rank test was used for survival analysis.
Kaplan-Meier methods were used to calculate the OS and DSS for each age group.
Kaplan-Meier plots and Cox proportional hazards regression models were used.
Kaplan-Meier plots and log rank test also showed the same findings.
Kaplan-Meier plots and log-rank tests were used to compare survival time of subgroups by depression variables and telomere length.
Kaplan-Meier plots and κ coefficients confirmed that the WBC cutoff value could predict development of MetS in women but not in men.
Kaplan-Meier survival estimates indicated that nonelderly patients had better survival than elderly patients ( P < @number@ ) .
Kaplan-Meier survival estimates were used to calculate the probability of remaining on anti-TNF therapy.
Kaplan-Meier survival functions provided estimates of uninsurance spell durations measured in waves , or 4-month intervals.
Kaplan-Meier unadjusted analysis showed reduced survival probability associated with moderate-to-severe cognitive status and physical disability.
Kaplan-Meier was used to assess survival time.
Kappa coefficients showed agreements between the TFI items and corresponding alternative measures.
Kappa statistics assessed inter-observer agreement , and McNemar's exact test assessed response differences.
Kappa statistics were calculated for each of the @number@ MAT items.
Kappa value showed diagnostic consistency.
Karlodinium micrum ( Strain NMBjah047 ) was isolated from the water samples of East China Sea ( ECS ) .
Karst chloroform extract ( FPKc ) on S180 tumor cells in vitro and in vivo and we determined the underlying mechanisms.
Karyotype analysis exhibited normal chromosomal numbers.
Kaufman's work has ongoing relevance to gerontological research on embodiment , chronic illness , and later life social transitions.
Kawasaki disease is a multisystemic vasculitis that can result in coronary artery lesions.
KCND2 is expressed in human skin , but has not been associated with aging.
KCNQ1 / KCNE1 channel activity and KCNQ1 / KCNE1 protein abundance were upregulated by coexpression of Klotho.
KCNQ1 / KCNE1 expressing oocytes were treated with human recombinant Klotho protein ( @number@ ng / mL ) for @number@ h.
KC-specific Par3 loss up-regulates surface P-cadherin that is essential to promote MC proliferation and phenotypic switch toward dedifferentiation.
KCTD17 knockdown in obese mice prevented PHLPP2 degradation and decreased expression of lipogenic genes.
KDM5B is modulated by RNF4 , an E3 ubiquitin ligase that targets SUMO-modified proteins to proteasomal degradation.
KDR , Tie-2 , Akt , and phospho-Akt protein levels were also assessed by Western blotting ( WB ) .
Keeping pace with rising demand for LTC poses a key challenge for health systems and policymakers , who may be slow to scale up capacity.
KEGG pathways were incorporated and links to external databases augment the information in GiSAO.db.
\ "Keller ' rules of fours \ " are introduced to summarize surgical pearls of the endoscopic forehead and brow lift.
Keloids and hypertrophic scars are fibroproliferative disorders ( FPDs ) of the skin that result from abnormal healing of injured or irritated skin.
Kendall's correlation analysis was used to identify the relationship between age and T2 / ADC mean values respectively.
Kentucky AgrAbility is evolving to include a more focused approach to the needs of underresourced and underserved regions and populations of farmers in Kentucky.
Keplerian loupe , @number@.3× , @number@ mm.
Keratinocyte and neutrophil viability did not change following the addition of QPEI to the orthodontic adhesives.
Keratinocyte-derived factors secreted from young and aged primary cells did not restore or inhibit LC migration from aged and young epidermis , respectively.
Keratinocyte overgrowth after UVB exposure is believed to contribute to skin photoageing and cancer development.
Keratinocytes , melanocytes , fibroblasts , and endothelial cells are altered by UV radiation.
Keratoacanthoma ( KA ) is a subtype of squamous cell carcinoma whose development has been linked to excessive sun exposure , immunosuppression , and trauma.
Keratocyte cell locations are then used to eliminate falsely detected microdots.
Keratocyte density significantly reduces with age in each stromal layer ( p < @number@ ) .
Ketogenic diets are high in fat and low in carbohydrates , and have long been used as an anticonvulsant therapy for drug-intractable and pediatric epilepsy.
Ketone bodies therefore are utilized as an energy source partially replacing glucose in the human diabetic heart.
Ketone levels were positively correlated with memory performance ( p = @number@ ) .
Ketones are the main alternative brain fuel to glucose so they represent a potential approach to compensate for the brain glucose reduction.
Key aspects of nursing practice , including involvement in advanced care planning , patient-centered care , and evidence-based practice , are essential for high-quality care.
Key avenues for future research are outlined , especially adapting principles of an epidemiological approach to understanding cognitive aging , broadly defined.
Key brain networks underlying cognition , emotion , and motivation are innervated by major transmitter systems ( e.g. , the catecholamines and acetylcholine ) .
Key characteristics of identified studies were extracted and summarized.
Key components of the extracellular matrix are proteoglycans , which are molecules composed of a core protein and covalently attached glycosaminoglycans.
Key components of the LINC complex are the nesprins ( Nuclear Envelope SPectrin Repeat proteINS ) that were initially described as large integral NE proteins.
Key covariates , including sociodemographic background , functional status , and service utilization , were also considered.
Key elements of these recommendations focus on improving interprofessional communication and improving HF-related knowledge among all LTC stakeholders.
Key Findings and Conclusions : Oncological rehabilitation is anchored in social legislation.
KEY FINDINGS : A significant decrease in the thickness of the INL in tau P301L mice was found when compared with that of control mice.
Key findings of research in progress at the University of Missouri are discussed in this viewpoint article , as well as obstacles to widespread adoption.
KEY FINDINGS : Patients showed slower reaction time to initiate a saccadic response compared to controls but had intact saccade accuracy.
KEY FINDINGS : @percent@ of the fluorescent heme degradation products in hemolysates are found on the membrane.
Key findings remained mixed in supporting specific intervention designs or delivery formats.
KEY FINDINGS : We analyzed @number@ clusters of epileptic spasms in @number@ patients ( @number@ girls ; mean age @number@ ± @number@ years ) .
KEY FINDINGS : We found that SIRT1 knockdown inhibited cell survival , proliferation , and functionality.
Key findings were replicated using long-term data from an independent cohort study.
Key independent variables were race , time ( pre-Part D vs post-Part D ) , and their interaction.
Key informants were interviewed by telephone to obtain qualitative data through standardized open-ended questions.
KEY ISSUES : Hospital design can help address the physical work challenges that older nurses experience.
KEY ISSUE ( S ) : Making the most of the multigenerational workforce and offering recommendations for meeting their unique challenges.
KEY MESSAGE : BPC @number@ promotes angiogenesis in CAM assay and tube formation assay.
KEY MESSAGES : Klotho deficient ( kl / kl ) mice suffer from hyperphosphatemia with dramatic tissue calcification.
Key messages : Mitochondrial DNA ( mtDNA ) copy number is associated with age and sex.
KEY MESSAGES : SMP30-deficient mice induced a shorter lifespan and redox changes.
Key messages Vasoactive factors are involved in the progression of calcific aortic valve disease.
Key methodological details to succeed in the use of this reporter are provided.
Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques - often surrounded by dystrophic neurites - and intracellular neurofibrillary tangles.
Key outcome variables for individuals with comorbid schizophrenia and diabetes were ED visits for diabetes , mental health-related conditions , and other causes.
KEY POINTS : Age significantly modifies the relationship between aortic pulse wave velocity and telomere length.
KEY POINTS Falls are a major health issue for older adults , leading to adverse events and even death.
KEY POINTS : Parotid fat content in healthy adults correlates positively with age and BMI.
KEY POINTS : The reduction in skin blood flow during whole-body cooling is impaired in healthy older adults.
KEY PRACTITIONER MESSAGE : Poor built environments have a negative impact on the level of a person's participation.
KEY PRACTITIONER MESSAGE : The Courage-SNI is a new tool to assess the construct of social network in population studies.
Key preoperative variables included age , comorbidities , and functional status based on the Karnofsky Performance Status score and modified Rankin Scale score.
Key resources are provided.
KEY RESULTS : Among @number@ HIV-infected participants receiving antiretroviral medications , @percent@ reported food insecurity.
KEY RESULTS : In all , @number@ % experienced discrimination infrequently and @number@ % frequently.
Key sources of informational and clinical support included pre-optimisation clinics , surgeons , and physiotherapists.
Key technical refinements are overlaid on a conceptual framework developed over the past @number@ decades by several investigators.
Key topics for informational support included pain , pain management , and recovery trajectories.
KEYWORDS Aging , quality of life , social environment , urban health , housing for the elderly , Cuba.
KEYWORDS Dementia , Alzheimer disease , aging , national health programs , social stigma , primary prevention , health promotion , civil rights , Cuba.
KEYWORDS Dementia , Alzheimer disease , chronic disease , aging , chronic illness , frailty , dependency , cohort studies , Cuba.
Keyword searches included the terms obesity , obese , overweight , menopause , and weight management interventions.
Keyword searches provide a quick way of finding some but not all relevant articles.
Keywords included sexual behavior , sexuality , cognitive functioning , healthy elderly , elderly , aging and dementia.
Keywords , used separately or in combination , were : prehabilitation , functional capacity , postoperative morbidity , physical activity.
KF decline occurred in @percent@ of the population , whereas incident CKD also occurred in @percent@ of those at risk.
KGDH is , however , also susceptible to oxidative damage.
Ki-67-positive nuclei decreased with time in culture.
KIAA0319 is a transmembrane protein associated with dyslexia with a presumed role in neuronal migration.
KIBRA showed evidence of overexpression in the AD temporal cortex ( p = @number@ ) but not cerebellum.
Kidney and brain expressed protein ( KIBRA ) , owing to its connection with human episodic memory , became an interesting candidate gene for AD.
Kidney biomarkers and Mini Mental State Examinations ( MMSEs ) were performed before procedure , at discharge and after @number@ months.
Kidney damage is a common sequela of several chronic pathologic conditions.
Kidney damage was defined as dipstick-positive hematuria or urinary protein : creatinine > @number@ g / g.
Kidney diseases , with some exceptions , are diseases of the elderly.
Kidney outcomes included kidney function ( KF ) decline ( @percent@ decrease in eGFR RESULTS : Two-thousand four-hundred and eighty-nine individuals were included.
Kidney-related pathologies are important contributors ( either directly or indirectly ) to overall human mortality.
Kidneys from diabetic Papp-A KO mice had significantly reduced or no evidence of changes in Bowman's capsule thickening and glomerular size.
Kidney-specific ageCGs are more increasingly methylated compared to other tissues as measured by affiliation with kidney-specific expressed genes.
Kidney tissues showed strong α-Klotho expression , whereas liver did not reveal a detectable signal.
Kidney transplantation can still result in improved life expectancy and quality of life in the elderly , in carefully selected people.
Kidney transplantation from living and deceased donors above age @number@ increased in recent years in response to organ shortage.
Kidney transplantation , haemodialysis and peritoneal dialysis are currently the gold standard of renal replacement therapy.
Kidney transplantation improves kidney function and abnormal mineral metabolism at the same time.
Kinase assay data revealed that DGC inhibited the kinase activity of MKK4 and PI3K and this outcome was due to direct physical binding with DGC.
Kinematic analysis revealed blast-induced head oscillation at accelerations sufficient to cause brain injury.
Kinematic and ground reaction forces were recorded.
Kinematic and kinetic data were recorded using a three-dimensional motion analysis system , and erector spinae activity was recorded by electromyography.
Kinematic differences between the groups remained a year later when all children could build high towers.
Kinematic information of CoM and both toes in addition to simulated impact force due to tripping at MFC were used to estimate ART.
Kinematic measures included : number of segments drawn , performance time , pressure implemented towards the drawing surface , and pen azimuth.
Kinematic measures of children's reaching were found to reflect stable differences in skill level for planning for future actions.
Kinematics was performed using an optoelectronic system , and linear and angular kinematic variables were determined.
Kinematic viscosity was determined with a capillary viscometer ( ViscoClock , Schott-Geräte Mainz , Germany ) equipped with a micro-Ubbelohde capillary.
Kinesthesia accuracy was significantly decreased in older adults compared with mid-aged and younger adults ( P≤.01 ) .
Kinesthesia , active and passive joint repositioning senses were tested at 0° and 10° external rotation.
Kinesthesia was evaluated by the ability to detect passive limb rotation without vision.
Kinetic and kinematic data were recorded.
Kinetic constants for interactions between PolγA-RECQL4 , PolγA-p53 and PolγB-p53 indicate that RECQL4 and p53 are accessory factors for PolγA-PolγB and PolγA-DNA interactions.
Kinetic signals were collected via a force platform under each foot.
Kinetic studies for the @number@ most active compounds indicated that majority of them were mixed-type BChE inhibitors.
Kinetic studies of AGEs and PEN formation in human cortical and cancellous bone matrix confirmed higher accumulation of fluorescent crosslinks for ribosylation.
Kinetic studies were performed at baseline and after each treatment period of @number@ weeks.
Kinetic theory assumes critical phenomenon : failure of adaptation when intensity of ENV impact becomes higher some critical level.
Kinetic theory of aging of living systems is proposed.
Kingsberg S , Krychman M , Graham S , et al.
Kinless-ness , defined both ways , is becoming more common among adults in their 50s and 60s for more recent birth cohorts.
Kinsey developed the scale from models created by his predecessors in human sex research.
Kin who were not moving themselves were also recipients of the gift of moving.
KIR expression was increased only in the CD56 ( bright ) subset.
Kissing , touching and other alternative sexual behaviors may be useful for the improvement of the senile sexual problems.
KL-6 was more prominently expressed in the bronchiolar / alveolar epithelium in COPD than in the control lungs.
Klinefelter syndrome ( KS ) is one of the most common genetic causes of male infertility.
Klingberg ( Trends Cogn Sci 14 : 317-324 , @number@ ) ] , thereby , however , confounding adaptivity and exposure to varying task difficulty.
Klinge et al.
KLO-1 associates with EGL-15 / FGFR , suggesting a role for KLO-1 in the fluid homeostasis phenotype described previously for egl-15 / fgfr mutants.
Klotho also is expressed in the parathyroid gland , where FGF-23 decreases parathyroid hormone expression and secretion , further suppressing vitamin D synthesis in kidney.
Klotho , an anti-aging factor expressed in the vessel walls that participates in the maintenance of vascular homeostasis , can be down-regulated by inflammation.
Klotho , an anti-aging gene , has recently been shown to contribute to human hepatic tumorigenesis.
Klotho , an anti-aging protein , has been reported to protect against atherosclerosis and ameliorate endothelial dysfunction in vivo.
Klotho concentration and TAC were significantly lower in patients as compared to controls.
Klotho concentrations have not been described in the CSF of humans.
Klotho counteracts vascular calcification and diverse age-related disorders.
Klotho deficiency induces resistance to FGF23 and predisposition to Pi retention , which represents a critical feature of pathophysiology of CKD.
Klotho deficiency may further result in hearing loss and cardiac arrhythmia.
Klotho deficiency results in early appearance of multiple age-related disorders and premature death , whereas overexpression of Klotho exerts the opposite effect.
Klotho-deficient mice develop multiple aging phenotypes , including impaired cognition.
Klotho deficient mice exhibit short lifespan and characteristics of aging and malnutrition , including decreased fat and muscle mass , osteopenia , and impaired fertility.
Klotho expression is inhibited by aldosterone.
Klotho F352V and IL-6-174G / C was G homozygous , C370S was T homozygous while IL-6-572G / C MAF less than @percent@.
Klotho-hypomorphic mice ( kl / kl ) suffer from severe vascular calcification and rapid aging.
Klotho induces phosphaturia by inhibiting the proximal tubule Na-coupled phosphate transporter.
Klotho inhibits basal Wnt signalling activity ; thus , the protein may function as a tumour suppressor for CRC.
Klotho is a gene primarily expressed in the kidney that has an important role in calcium-phosphate homeostasis.
Klotho is a key modulator of the aging process and , when overexpressed , extends mammalian lifespan , increases synaptic plasticity , and enhances cognition.
Klotho is a major determinant of aging and life span.Overexpression of Klotho increases and Klotho deficiency decreases life span.
Klotho is an anti-aging and anti-fibrotic protein and its early decline after renal injury is reportedly associated with aberrant DNA methylation.
Klotho is an anti-aging factor mainly produced by renal tubular epithelial cells ( TEC ) with pleiotropic functions.
Klotho is an anti-aging transmembrane protein , which can be shed and function as a hormone.
Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-receptor that makes the fibroblast growth factor ( FGF ) receptor specific for FGF-23.
Klotho is a transmembrane protein expressed primarily in kidney , parathyroid gland , and choroid plexus.
Klotho is down-regulated in acute kidney injury in native kidney ; however , the modulation of Klotho in kidney transplantation has not been investigated.
Klotho is in part effective as β-glucuronidase regulating protein stability in the cell membrane.
Klotho ( KL ) is an age-regulating protein named after the Greek goddess who spins the thread of life.
Klotho knockout mice display accelerated aging , and in humans Klotho circulating levels decline with age , renal disease and diabetes.
Klotho may play an important role in the pathogenesis of MS , at least in part , through the regulation of redox system.
Klotho mRNA expression was quantified in kidneys obtained from long term ( @number@ and @number@ months ) diabetic Ins2Akita mice and normoglycemic control mice.
Klotho protected and stimulated beta cells and lack of Klotho ( KD ) was reversed by soluble Klotho.
Klotho protects against renal and vascular injury.
Klotho reduced EOC cell viability , enhanced cisplatin sensitivity , and reduced expression of mesenchymal markers.
Klotho reduces calciuria by its distal as a sialidase directly on the apical calcium channel.
Klotho values showed a significant negative correlation with expanded disability status scale ( EDSS ) .
Klotho was first discovered as an aging-suppressor gene.
Klotho was found to increase the plasma membrane stability of TRPV5 , via the TRPV5 N-glycan.
Klotho which was originally identified as an anti-aging protein is emerging as a substance with multiple effects on many systems including mineral homeostasis.
KLS and AOSS were significantly higher in the group ≥18 years ( p < @number@ ) .
KL-VS genotyping ( rs9536314 T / G ) followed standard procedures.
Klyflaccisteroid K ( @number@ ) is the unique @number@ , 11-secosteroid with a @number@ , 8-epidioxy-9-ene functional group.
Klyflaccisteroid L ( @number@ ) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources.
K-means cluster analysis was used to classify the participants ' physical activity levels based on parameters of volume and intensity.
Knee adduction moment correlated with structural parameters in the subset of OA patients.
Knee and ankle joint movements differed between the two groups during the backward COP shift.
Knee and hip kinetics and knee co-contraction were calculated.
Knee and hip kinetics ( moments and powers ) are greater for longer steps and for younger subjects , but younger subjects also step farther.
Knee and hip radiographs were classified according to Kellgren and Lawrence ( K / L ) scoring from grade @number@ to grade IV.
Knee , ankle , and hip joint angles and moments were determined.
Knee extension strength was assessed as an indicator of muscle strength , and bioelectrical impedance analysis was used to measure muscle mass.
Knee extension strength was measured by isokinetic dynamometer in Years @number@ @number@ @number@ @number@ and @number@
Knee extensor and flexor isometric muscle strength were measured using Biodex System @number@ Pro™ dynamometers.
Knee extensor muscle cross-sectional area ( CSA ) , knee extension force , running speed and vertical jumping height were measured.
Knee OA was also a significant risk factor for shoulder OA ( OR , @number@ P = @number@ ) .
Knee osteoarthritis ( OA ) , a leading cause of disability , is more prevalent in women than men.
Knee Osteoarthritis Outcome Scores were used to quantify knee pain and functional status between walking sessions.
Knee pain is a frequent complaint in ambulatory practice.
Knee pain is commonly seen in orthopedic and rehabilitation outpatient clinical settings.
Knee pain is commonly seen in orthopedic and rehabilitation outpatient clinical settings , and in the aging population.
Knee pain was most severe in the short leg for @number@ of @number@ participants ( @percent@ ) .
Knee pain worsening was also examined in OAI.
Knee range of motion was lower for knee-OA participants in the fast-walking and usual-walking-after-30 min tasks ( p < 0.030 ) .
Knoblauch and others attempted to localize music function in the brain.
Knockdown ( KD ) of Klotho with siRNA in INS-1E insulinoma cells abrogated the protective effects of GABA against STZ toxicity.
Knockdown of BCAT1 represses the growth rate and colony formation capacity of breast cancer cells , opposing results are observed when BCAT1 is overexpressed.
Knockdown of Beclin-1 or inhibition of autophagy by 3-methyladenine ( an inhibitor of autophagy and PI3K ) rendered them significantly more sensitive to chemotherapy.
Knockdown of CD98hc expression in HeLa cells demonstrated that it is essential for Brucella infection.
Knockdown of cyclin K in a testicular cancer cell line markedly reduces cell proliferation.
Knock-down of either HDAC1 or @number@ led to increased transcriptional activity by both HDACs , presumably by decreased repression.
Knock-down of ERRα by siRNA-based approach led to constitutive induction of EGFR and HB-EGF levels , and eliminated the biological responses of AM251 and XCT790.
Knockdown of KCTD17 with small hairpin RNA in primary hepatocytes increased PHLPP2 protein but not Phlpp2 mRNA , indicating that KCTD17 mediates PHLPP2 degradation.
Knockdown of p21 in MSCs also increased the telomerase activity and telomere length , and did not show chromosomal abnormalities or acquire transformation ability.
Knockdown of P27 as well as overexpression of SKP2 both suppressed the SEA-induced senescence of HSCs.
Knockdown of PARP1 reduces TERT expression and telomerase activity not only in cancer cells , but also in human and mouse ESCs.
Knockdown of PINK1 expression in lung epithelial cells resulted in mitochondria depolarization and expression of profibrotic factors.
Knockdown of PlGF transcripts reduced RA-FLS proliferation in a xenotransplantation model.
Knockdown of Pot1a induced an age-related phenotype , characterized by increased telomeric DDR and reduced long-term reconstitution activity.
Knockdown of RNF126 prevented Ku70 / 80 dissociation from DSBs and inhibited break repair.
Knockdown of SIRT6 up-regulates TRF2 protein levels and counteracts its down-regulation during DNA damage response , leading to cell survival.
Knockdown of SPP1 , GLI1 or CD44 with siRNAs diminished sphere formation.
Knockdown of TrkB in human lung cancer cell lines significantly decreased their migratory and metastatic ability in vitro and in vivo.
Knockdown of UBE2E3 reduces nuclear Nrf2 , decreases Nrf2 target gene expression , and relocalizes the transcription factor to a perinuclear cluster of mitochondria.
Knockdown of Wip1 aggravated the increased permeability and decreased transepithelial electrical resistance , protein expression of ZO-1 , and occludin induced by LPS.
Knock-down of WWP1 abrogates DNA damage-induced down-regulation of ΔNp63αand partially rescues cell apoptosis.
Knockdown of α-synuclein in the SNCA-Tri NPCs by stably expressed short hairpin RNA ( shRNA ) resulted in reversal of the observed phenotypic changes.
Knock-out mice have been used to define the role of the various NOS isoforms on the origin of the abnormal development.
Knockout Synj1 ( - / - ) mice have convulsions and die early in life.
Knowing the biological age of the neonates enables us to evaluate and better understand the health and maturity comprehensively.
Knowing the characteristics of older injured workers may help in developing interventions to reduce the likelihood of work disability.
Knowing their perspective on caregiving is important if health professionals are to help them evolve into a caregiving role.
Knowing these changes may elucidate structural , metabolic , and functional brain processes over the lifespan , as well vulnerability to neurodevelopmental or neurodegenerative diseases.
Knowing which resilient attributes are most effective in facilitating transitioning would be especially useful in the development of preventative holistic patient-centered nursing interventions.
Knowing which types of control beliefs older men emphasize as they age has theoretical and practical implications.
Knowledge about CeAD and IAD has advanced substantially.
Knowledge about fertility issues was similar between genders including poor knowledge about the age-related decline in female fertility.
Knowledge about how visual functions , light and ocular diseases is needed for work design and preventive actions.
Knowledge about optimal values of selected cardiovascular risk factor indicators increased with age , but not the perception of the importance of age itself.
Knowledge and attitudes could influence the quality of information and counselling given to patients.
Knowledge and confidence surveys demonstrated improvements before and after training ( P < .001 ) .
Knowledge and confidence surveys demonstrated improvements pre- and posttraining ( p < @number@ ) .
Knowledge and confidence were assessed with pre- and postsurveys.
Knowledge barriers included lack of information regarding diabetes and the associated risk of complications.
Knowledge changes and pain beliefs were assessed postvideo and at a four-week follow-up.
Knowledge from this study can be used to assist and improve future implementations in primary healthcare centres.
Knowledge of aging and dementia is rapidly evolving with the aim of identifying individuals in the earliest stages of disease processes.
Knowledge of deciduous crown formation times is useful in forensic anthropology and when aging juvenile remains from an archaeological context.
Knowledge of inter- and intra-individual variability of dietary vitamin K intake could be useful to accurately assess usual intake and rank participants in epidemiological studies.
Knowledge of mechanical behaviour of the aorta has been customarily constrained by lack of data on fresh aortic tissue , especially from healthy young individuals.
Knowledge of memory tasks was linked to a significant memory decline.
Knowledge of NP cell-ECM interactions can be used for development of tissue engineering or cell delivery strategies to treat IVD-related disorders.
Knowledge of postmenopausal hair changes is important for clinicians to distinguish between normal physiological change and those that require further medical investigation.
Knowledge of sex differences in typically developing adolescents can provide a basis for interpreting sexual dimorphisms in abilities and actions.
Knowledge of strategies to promote optimal quality of life for PD patients is of paramount importance for caregivers , health providers and patients themselves.
Knowledge of the ageing process , implementation of an evidence-based programme and a multidisciplinary approach is a basic ingredient to prevent functional decline.
Knowledge of the biochemical properties and life cycles of dermal fillers guided the decision to surgically excise the nodules , with cosmetically satisfactory results.
Knowledge of the deterioration rate of CKD may anticipate adjustment of therapies with renal elimination.
Knowledge of the extent and manner in which older adults combine prescription drugs will aid healthcare professionals in appropriately identifying and managing patients at risk.
Knowledge of the imaging spectrum of disease entities that may cause dysphagia and thorough radiologic assessment with a tailored approach may help avoid misdiagnosis.
Knowledge of the least frail group characteristics may provide insight into possibilities to prevent early frailty in older people with intellectual disabilities.
Knowledge of the molecular mechanisms involved in this cellular protection could be critical for developing treatments to prevent and control excessive progression of neurodegenerative disorders.
Knowledge of the relations of exchangeable zinc pool ( EZP ) size to relevant variables is necessary to adequately evaluate its use as a biomarker.
Knowledge of these associations can elucidate various clinical presentations and guide therapeutic choices in the future.
Knowledge of these associations may help in developing interventions to reduce fear of falling and activity avoidance in old age.
Knowledge of these mechanisms may yield new therapeutic targets.
Knowledge of these patterns is important for effective policy and program development.
Knowledge of the US appearance of normal joints by age might aid diagnosis of pathologies.
Knowledge of this infection among the general population continues to be extremely limited.
Knowledge of this is important in investigations of neurophysiological aspects of swallowing.
Knowledge on the effectiveness of rehabilitative procedures is needed and information in physical performance between men and women is scarce.
Knowledge on the variation of F2RL3 methylation by various degrees of smoking exposure is still very sparse.
Knowledge on the ventricular repolarization in very old individuals is limited.
Knowledge scores reflected good knowledge ; however , only @percent@ of the sample felt that they had adequate knowledge of older adult sexuality.
Knowledge scores significantly improved in both study groups.
Knowledge translation should be implemented throughout the development and application of research knowledge to inform HIV clinical practice , programming and policy.
KNOWLEDGE TRANSLATION : The IOM recommendations identify key areas of concern to nurses.
Knowledge users ( n = 3 ) also participated in the consensus meeting.
Knowledge was also better among men and women who had been tested for STIs or reported ' other ' sources of knowledge on STIs.
Knowledge was assessed at baseline and @number@ months.
Known AMD risk factors , including smoking , are significantly associated with the progression to bilateral involvement.
Known-groups validity was demonstrated for all domain scores , subdomain scores , and total score based on the Clinical Global Impression-Severity.
Known-groups validity was evaluated comparing good-health and bad-health participants.
Known groups validity was observed using functional limitations and subjective health as grouping variables.
Known-groups validity was supported by the separation of mechanically ventilated and nonventilated assessments.
Known variants in ANG , OPTN , SETX , and TARDBP were identified in @number@ patients.
Kofam.ch SNCTP000001751.
Korean and Russian participants endorsed the view of depression as a personal weakness more than participants in the USA.
Kosterm. var. paniala ( Roxb. )
KP and KI were significantly correlated with the power ratio of medium frequency.
KRAS , BRAF , and PIK3CA mutational status of tumors was assessed.
Krill oil was also found to protect against oxidative damage , lipid peroxidation and neurodegenerative diseases.
Krippendorff's alpha was used to evaluate interrater reliability and agreement.
Krones et al.
Kruskal-Wallis analysis of variance and Mann-Whitney U tests were performed to test for differences in fracture strength values at a @percent@ significance level.
Kruskal-Wallis and Mann-Whitney tests were performed on delta values at @number@ @number@ and @number@ months.
Kruskal-Wallis test and chi-square statistics were used to identify significant differences by sociodemographic and self-reported health characteristics.
Krychman M , Graham S , Bernick B , et al.
KS patients have also an increased probability of endocrine and / or metabolic disease , especially obesity , metabolic syndrome and type @number@ diabetes mellitus.
KStrength60° , age , and level of physical activity explained @percent@ of MGS variance ( p < @number@ ) in the global model.
Ku also functions to prevent tumorigenesis and senescence since Ku-deficient mice show increased cancer incidence and early onset of aging.
Kuru plaques and coarse plaque-type PrP depositions also were observed in the cerebellar cortex.
KY17-induced autophagy and apoptotic cell death in human colon cancer cells ( HT-29 ) was investigated.
KY17 treatment induced growth inhibition and apoptotic cell death in a concentration-dependent manner.
Kynurenine pathway ( KP ) is the primary path of tryptophan ( Trp ) catabolism in most mammalian cells.
Kyphosis was measured using the Rancho Bernardo Study block method.
Kyphosis was not associated with grip strength in any multivariate analysis.
L1 and AoA effects were more readily overcome in semantic processing ; accented variants regularly created priming effects in the different groups of bilinguals.
L1 , L5 , and VLDL also increased the in vitro tumorigenesis of breast cancer cells in anchorage-independent soft agar assay.
L1 , L5 , and VLDL increased Akt Ser473 phosphorylation and promoted cell migration , which were reversed by the PI3K / Akt inhibitor wortmannin.
L1 was the only level with predominantly concave morphology.
L4 had the highest proportion of convexity ( @percent@ ) .
L5 but not L1 induced human adipocytes to release inflammatory adipocytokines.
Labels were validated as HarP compliant through centralized quality check and correction.
Labial thickness , vermilion area , and volume of the upper and lower lips were measured from the digital reconstructions.
Laboratories solely studying senescence , scientific conferences and organisations dedicated to field of cellular senescence are also on the rise.
Laboratory and endocrinologic testing , including the free testosterone ( FT ) level , was performed with blood samples collected before @number@ : @number@ am.
Laboratory assays of kidney function were also performed.
Laboratory assessments , and EEG and MRI of the brain were in agreement with aging , but all results were within the normal range.
Laboratory data showed a low plasma potassium level.
Laboratory data showed mild elevation of serum amylase in the eT2DM group , although clinical signs and symptoms of pancreatitis were not apparent.
Laboratory data were available in @number@ of the @number@ patients.
Laboratory diagnostics is especially important in the diagnosis of certain diseases.
Laboratory emotion-recognition tasks may therefore underestimate older adults ' empathic competencies.
Laboratory investigation showed no abnormalities.
Laboratory investigations showed positive results of EBV antibody titer and elevated EBV-DNA in the spinal fluid.
Laboratory mice have longer telomeres relative to humans , potentially protecting against age-related disease caused by haploinsufficiency.
Laboratory models of Ccr2-mediated β-amyloid removal and regulation of neurogenesis affecting cognitive function may be applicable in humans.
Laboratory parameters including leptin , IGF-1 , IGFBP-3 , IL-6 , TNF-α were measured.
Laboratory service fees were reduced from $ 300 per participant to $ 5 per participant.
Laboratory studies , abdominal ultrasound , and upper and lower digestive endoscopies were performed to rule out organic issues.
Laboratory studies fail to find a biomarker of senescence.
Laboratory studies on the basic biology of ageing have shed light on numerous genetic pathways that have strong effects on lifespan.
Laboratory tests showed normal ranges for the cohort.
Laboratory tests showed normal sodium levels , and the renal insufficiency had improved.
Lacking convincing evidence , this study examines the presence and associated socio-demographic / clinical characteristics of apathy in older compared to younger depressed persons.
Lacking disconnection of this resting state network is predictive of aging-related short-term memory decline.
Lacking the inhibitory effect on the vitamin K cycle , the consequent side effects can be avoided.
Lack of activity during hospitalization may contribute to functional decline.
Lack of association was not because MetS was predictive of subsequent mortality.
Lack of attention to missing data in research may result in biased results , loss of power and reduced generalizability.
Lack of awareness about the magnitude of the current and future cancer burden among policy makers play a major role as well.
Lack of awareness of eye conditions can result in missed treatment.
Lack of awareness of hypercholesterolaemia was high across the remainder of the population.
Lack of consistency in the definition of SA is a fundamental weakness of SA research.
Lack of dose response and fewer AEs suggest that treatment of hyperdynamic POLs with @number@ U appears adequate for up to @number@ weeks.
Lack of evidence-based data continues to be the major impediment toward delivery of personalized cancer care to elderly breast cancer patients.
Lack of flexibility in work and training programmes continue to provide challenges in creating a diverse surgical workforce.
Lack of funding was identified as a barrier that limited support for employee education / training.
Lack of incentives was identified as a barrier to credentialing or certification.
Lack of insurance may compromise access to care and therefore compromise survival.
Lack of perseverance was positively associated with obsessive-compulsive symptoms and harm avoidance trait , and negatively related to persistence and self-directedness traits.
Lack of teamwork in cancer care can result in serious clinical errors , fragmentation of care , and poor quality of care.
Lack of training was mostly envisaged by physicians with the least number of years in general practice.
Lack of understanding of the disease mechanism hinders the development of efficacious therapeutic approaches.
Lacrimal gland function has been shown to decrease with aging , a known potent risk factor for dry eye.
Lactase gene expression declines with aging ( lactase non-persistence ) in the majority of humans worldwide.
Lactate acts as a ' buffer ' between glycolysis and oxidative metabolism.
Lactate dehydrogenase was higher ( P < 0.05 ) during the anatabine condition.
Lactate exits cells through monocarboxylate transporters in an equilibrating manner and through astrocyte anion channels activated by depolarization.
Lactate production generates VEGF expression and then participates to the initiation of CNV in exudative AMD.
Lactate reduced ABCB1 activity.
Lactate utilization declined in parallel to the decline in glucose transport suggesting lactate did not serve as an alternative fuel.
Lactate was measured at baseline and at @number@ min from exercise onset.
Lactation may have long-term benefits that lower cardiovascular disease risk in women.
Lacunar strokes and white matter ( WM ) injury are consequences of SVD.
LA filling , passive emptying , conduit and active emptying volumes , and fractions were calculated.
Lagged analyses demonstrated that immunological parameters were affected by the number of respiratory infections in the preceding @number@ months.
Lagged dependent variable models were used to examine effects.
Lagged effects indicated lower happiness led to greater subsequent SOC usage.
Lag time , thrombin peak , time to thrombin peak and endogenous thrombin potential ( ETP ) were analyzed.
Laguerre expansions of the Wiener-Volterra autoregressive terms account for the long-term nonlinear information.
LA-ICP-MS can be employed to detect metalloproteins in protein bands or spots separated after gel electrophoresis.
LA intake tended to be associated with FN-BMD loss in women ( P for trend < @number@ ) .
LA is also involved with anti-inflammatory action , independently of its antioxidant activity.
LA-KTTKS and LA-PEG-KTTKS also inhibit UV-induced matrix metalloproteinase-1 expression up to @percent@ and @percent@ at @number@ mM , respectively.
Lambl's excrescences are mobile , thin , filiform structures that occur at sites of valve closure.
( Lamiaceae ) is a traditional herb that is consumed in East Asian countries as a traditional medicine.
Lamin A / C-depleted cells exhibited a flat morphology and accumulated markers of cellular senescence.
Lamin-A / C is a common molecular factor , and methods are presented for its knockdown and measurement.
Lamin A is a nuclear intermediate filament protein with important structural and regulatory roles in most differentiated mammalian cells.
Lamin B1 reduction in proliferating cells triggers senescence and formation of mesas and canyons.
Laminopathies are a group of diseases that share wrong codification of lamins , building proteins of the nuclear lamina.
Laminopathies are reviewed in this article from a molecular , pathogenic and clinical point of view.
Laminopathies include lipodystrophies , muscle and cardiac diseases as well as metabolic or progeroid syndromes.
Lamins A / C have been implicated in DNA damage response pathways.
Lamins A / C regulate 53BP1 levels and consequently lamin A / C-null HDF display a 53BP1 null-like phenotype.
Lamins are important constituents of the nuclear inner membrane and provide a platform for transcription factors and chromatin.
Lamins are intermediate filament proteins that form a scaffold , termed nuclear lamina , at the nuclear periphery.
Lamins are nuclear intermediate filament ( IF ) proteins.
Lamins are nuclear intermediate filaments ( IFs ) with important roles in most nuclear activities , including nuclear organization and cell-cycle progression.
Lamins are required to maintain the nuclear structure and , together with their associated proteins , are involved in most nuclear activities.
Lamins help maintain the shape and stability of the nuclear envelope in addition to regulating DNA replication , DNA transcription , proliferation and differentiation.
Lamtor1 wraps around the other four subunits to stabilize the assembly.
Landmarks on the atlas skull were transformed to each subject and partitioned into the inner and outer cranial vault and the cranial fossae.
Land-use regression models can improve exposure assessment for TRAP.
Langerhans ' cells ( LC ) play pivotal roles in skin immune responses , linking innate and adaptive immunity.
Language abilities are known to deteriorate in aging , possibly related to decreased functional and structural connectivity within specialized brain networks.
Language acquisition has long been discussed as an interaction between biological preconditions and environmental input.
Language-and culture-specific norms are needed for research on emotion-laden stimuli.
Language group differences were most clear in the Stroop task , with bilinguals showing superior performance both behaviourally and electrophysiologically.
Language impairment in Alzheimer's disease primarily occurs because of decline in semantic and pragmatic levels of language processing.
Language is a crucial and complex lifelong faculty , underpinned by dynamic interactions within and between specialized brain networks.
Language performance was assessed by measures of accuracy and reaction time on two tasks of lexical retrieval and two tasks of sentence processing.
Language tests seem to be more efficient than the MMSE to detect early changes in cognitive status.
Language was uniformly affected across levels of vision impairment.
Laninamivir octanoate was inhaled once on day @number@ and oseltamivir ( @number@ mg ) was administered orally twice daily for @number@ days.
Laparoscopic peritoneal lavage was made in urgency in five cases.
Laparoscopic radical cystoprostatectomy ( LRCP ) is still an experimental technique in evaluation.
Laparoscopic sleeve gastrectomy has shown to improve the renal function @number@ months after surgery.
Laparoscopic surgery is minimally-invasive , and performance on severe kyphotic patients may cause difficulty to approach a narrow abdomen.
LA-peptide conjugates stimulate collagen biosynthesis in fibroblasts more efficiently than their parent molecules do.
LAP was compared among the age groups and between women and men.
LAP was lower in women than in men in the younger groups and was higher in women than in men in the oldest group.
LA reservoir function is likely to decrease with age and increasing of body size.
Large artery stiffness was measured with carotid-femoral pulse wave velocity ( PWV ) .
Large blood vessels were also excluded.
Large chronic ulcers with urgent bleeding are less likely to respond to endoscopic retreatment.
Large clinical studies are required to develop new strategies for perioperative management in such patients , including the adjustment of anaesthesia techniques.
Large disadvantages in prevalent and incident CI were observed for all REN minorities respective to US-born non-Hispanic whites.
Large dVRS were detected in @percent@ of participants.
Large effect size associations between clinical variables and the different HRQOL domains were looked for.
Large effect size ( @number@.873-3.362 ) for improvement of pain relief was found in @number@ of the @number@ studies examining the effectiveness of gabapentin.
Large efforts from both academia and industry have been devoted in the last a few decades.
Large healthcare interventions and pharmacological trials are in progress.
Largely because of low life expectancy , Indigenous Australians are considered to be ageing from the age of @number@ years.
Large microaneurysms showed diminution of protein content , as well as disorganization , in their basement membrane.
Large national and international registries have been established to capture those at risk and to follow their development of cognitive changes longitudinally.
Large optimal resection , when achievable , should be preferred to biopsy.
Large phase III trials over long time periods are currently being conducted for Parkinson's disease and Huntington's disease , and will possibly solve this issue.
Large prospective studies with extended follow-up periods and multifaceted cost-outcome analysis are needed to refine the appropriateness of spine surgery.
Large PVSs should be included in assessments of vascular cognitive impairment in the older population and as potential targets for interventions.
Large randomized controlled studies , however , showed that estrogens did not treat dementia symptoms and even increased risk for dementia in older women.
Larger animal models , such as porcine , have been validated as appropriate models of the human disc with respect to biomechanics and biochemistry.
Larger Cornu Ammonis ( CA ) 1-2 volume was associated with faster distance shortening , but not in path complexity reduction.
Larger declines in either IGF-I or II were associated with higher fat mass at 60-64 years.
Larger diagnostic studies are needed to evaluate potential use of miRNA expression in early detection and diagnosis of CRC.
Larger distal cross sections had thinner porous cortices of lower matrix mineral density ( MMD ) , a larger medullary CSA and higher trabecular density.
Larger fat mass was related to significantly greater muscle strength but significantly lower muscle quality at baseline ( p < @number@ ) .
Larger future studies should confirm this association and investigate methods to minimize recurrent falls through management of such medications.
Larger late P2 amplitude to novels was associated with better behavioral performance.
Larger , multicenter trials are needed to confirm these findings and to determine the effect of these assessments on delirium recognition in the ED.
Larger prospective studies are needed to examine the power of this relationship.
Larger randomized , controlled trials are warranted.
Larger RCFs were also more likely than small RCFs to provide social services counseling and case management.
Larger relative side asymmetries in men , younger players and young starters suggest a greater potential for exercise benefits to bone in these groups.
Larger samples and longitudinal studies are needed to further confirm our results in the future.
Larger sample size and low attrition were associated with smaller estimates of effect.
Larger scale research is needed to confirm findings and potentially extend BRIDGE to other client problems , professions , and service sectors.
Larger-sized studies with longer treatment durations are needed to confirm this.
Larger step width variability was observed in both the Brooks ' Spatial Memory and Counting Backward dual-task conditions than in the baseline condition.
Larger studies are needed to better characterize vitamin D status and possible correlations with premature hormonal aging reported in long-term TC survivors.
Larger studies are needed to clarify how these domains change over time and whether or not they improve with treatment.
Larger studies are needed to confirm the benefits of β-1 , @date@ @number@ glucan on URTIs in this older population.
Larger studies are needed to define immune parameters associated with better control of RhCMV in adult compared to young animals.
Larger studies are needed to explain these findings.
Larger studies are needed to understand the clinical implications of this finding.
Larger studies are required to determine age-dependent disease risks for BC and to assess a potential role of FANCM mutations in OC pathogenesis.
Larger studies are underway to study optimal techniques for administering HA and BNT combined in a single syringe.
Larger studies are warranted to elucidate the role of carbonyl content as a biomarker for premature aging in HIV / AIDS patients.
Larger studies of this potentially valuable therapy for glycemic control in the ICU are justified.
Larger studies that focus on fatal PCa are needed to identify more markers that could aid prediction.
Larger studies to determine if frailty independently predicts outcomes are warranted.
Larger studies with robust methodology are required to confirm this.
Larger total WMH volume was correlated with smaller total gray matter volume ( p < @number@ ) .
Larger treatment effects may be observed among BT trials with older participants , more therapeutic contact , and less co-occurring ADHD.
Larger walking speed errors were associated with higher discrimination thresholds.
Larger , well-designed studies are needed to confirm these findings and explore sources of heterogeneity.
Large sample properties of the estimators are established and their small sample behavior is studied using simulations.
Large-scale clinical studies regarding telomere length measurement , including genome wide association analysis introducing relevant genetic factors , are needed for the future.
Large-scale genome-wide association ( GWA ) analyses of adult height in Europeans have identified nearly @number@ genetic loci.
Large-scale initiatives to expand evidence-based practices are often poorly implemented and rarely endure.
Large-scale , prospective studies are necessary to validate this neural mechanism , and develop predictive markers for use in clinical practice.
Large-scale prospective studies in multiethics population are required to provide stronger evidence in the future.
Large-scale randomised controlled trials are needed to fine-tune the indications and optimal dosing protocols before DHEA enters routine clinical practice.
Large-scale studies are needed for the identification and validation of biomarkers , and the analytical techniques required have recently been developed.
Large-scale validation remains nevertheless mandatory to elucidate whether such an approach can improve the early detection of mesothelioma.
Large side asymmetries in bone strength were found in veteran players , which were more pronounced in men , younger players and childhood starters.
Large variability in yoga styles and measurement outcomes make it challenging to interpret results across studies.
Large vessel ischemic stroke represents the most disabling subtype.
Large well-designed trials are needed to compare the efficacies of vitamin K1 and K2 on fractures.
L-Arginine-HCl was continuously infused [ intravenously ( IV ) ] in three stepwise-increasing doses ( @number@ @number@ and @number@ μmol·kg-1·h-1 ) .
Laron syndrome ( LS ) is a unique model of congenital IGF-I deficiency.
Larval and pupal abundance was greater in Nogales , and adult density was only higher in Hermosillo during September.
Laryngeal dysfunction in the elderly is a major cause of disability , from voice disorders to dysphagia and loss of airway protective reflexes.
Laryngeal mask airway placement occurred when the heart rate dropped at least @percent@ from its maximum level or at @number@ min.
Laryngeal muscles were then dissected and used for histological examination of morphology and age-related denervation.
Larynges were obtained from eight embalmed cadavers aged 72-98 years.
Laryngoscope , 126 : 672-677 , @number@
Laryngoscope , 127 : 1257-1262 , @number@
Laryngoscope , 127 : 1885-1889 , @number@
Laryngoscope , 127 : 2572-2577 , @number@
Laryngoscope , 127 : E354-E358 , @number@
Laryngoscope , 127 : E399-E407 , @number@
Laryngoscope , 128 : 102-110 , @number@
Larynx anterior commissure was extracted and divided into @number@ subregions : supraglottic , glottic and subglottic.
Laser blepharoplasty offers the possibility to perform incision and haemostasis with the same device.
Laser Doppler flowmetry was used to measure skin blood oscillations.
Laser-Doppler flux increased in both groups with LH ( both d > 1.8 , p < 0.001 ) .
Laser-induced breakdown spectroscopy ( LIBS ) is applied to analyze human fingernails using nanosecond laser pulses.
Laser light therapy has continued to diversify with the use of ablative and nonablative resurfacing technologies , fractionated lasers , and their combined use.
LASER PARAMETERS : There are different machines based on different technologies available.
Laser resurfacing provided @number@ years of apparent age reduction ( p < @number@ ) .
Lasers and lights determine ablation , contraction and regenerating stimulus in skin tissues.
Laser scanning confocal microscopy was used to observe and measure the upper palpebral conjunctiva and meibomian glands.
Laser skin resurfacing has shifted over the past two decades from standard ablative resurfacing to non-ablative resurfacing and most recently , to fractional laser resurfacing.
Lasers , radiofrequency , botulinum toxins , fillers , and a host of other treatments are used to treat the periorbital region.
Lasers Surg. Med.
Laser toning failed to significantly improve melasma in all five patients.
Laser treatment led to up-regulation of nidogen-1 protein expression in the sclera / choroid of nidogen-2 deficient or WT mice.
Laser treatment was performed using a CO ( @number@ ) fractional resurfacing device.
Laser treatment was performed with a SmartXide DOT Fractional CO2 Laser ( DEKA Laser Technologies , Inc. ) emitting a wavelength of @number@ μm.
LASSI-L merits further studies to evaluate its ability to detect preclinical AD and predict progression to aMCI and early dementia.
LASSI-L raw scores were correlated with age and years of education , but not gender.
LASSI-L sub-scores representing maximum storage capacity , recovery from proactive interference , and delayed recall yielded the highest diagnostic accuracy.
Last , BAL from EPPE mice and patients with HPS1 enhanced migration of RAW267.4 cells , which was attenuated by immunodepletion of SP-D and MCP-1.
Last follow-up radiographs showed a stable hip with no evidence of avascular necrosis of the femoral head.
Last , future challenges in the field are outlined , including perspectives of both chemistry and biology ( @number@ references ) .
Last group of challenges concerns to managers and politicians and must be focussed on the look for resources and educational promotion.
Last , HOMA-IR was not demonstrated in association with peak leg strength.
Lastly , adverse effects from medications prescribed for treatment of COPD may be more pervasive in elderly patients.
Lastly , body mass index and blood pressure were discussed for their relations with the cognitive changes.
Lastly , CA at @percent@ of humerus length and cortical thickness at non-attachment sites decreased with age.
Lastly , enzalutamide also inhibited cell proliferation of HTB5 bladder cancer cells that express AR and possess intrinsic resistance to gemcitabine.
Lastly , fibrinolysis is responsible for clot dissolution once tissue repair and regeneration permit the return of normal blood flow.
Lastly , genetic counseling issues which may be important to the community clinician are discussed.
Lastly , hand and its related interactions were not found significant.
Lastly , home-care nurses , talk about ' promoting choices ' is also investigated.
Lastly , I highlight major research gaps and future policy relevant research directions to advance the field of elder abuse.
Lastly , @number@ genes with age-associated expression were also associated ( FDR ≤ @number@ ) with pulse pressure independent of chronological age.
Lastly , small-molecule inhibitors of DYRK1B prolonged NKX3.1 half-life.
Lastly , substitution of GDF11 residues into GDF8 confers enhanced activity to GDF8.
Lastly , suggestions for pelvic healthcare that focus on women's needs are made.
Lastly , survival tests were applied.
Lastly , the authors consider critical aspects of vascular repair , including autologous transplantation of bone marrow-derived stem cells in elderly patients.
Lastly , the consequences for eating behaviour and nutrition are evoked.
Lastly , the high levels of Caspase-6 in the gastrointestinal system indicate a potential specific function of Caspase-6 in these tissues.
Lastly , the non-fluent group showed no increase in learning disability or non-right-handedness.
Lastly , there is no evidence that prenatal exposure to HAART increases the risk of cancer in childhood , but long-term studies are needed.
Lastly , the role of the immunoproteasome during the development of cardiac hypertrophy was investigated.
Lastly , we conducted an exploratory analysis to test whether having suffered an mTBI might exacerbate age-related cognitive decline.
Lastly , we consider whether the impact of the multi-morbidity on disability varies by socio-demographic characteristics.
Lastly , we demonstrate quantitatively that these DERs associate with a changing neuronal phenotype related to differentiation and maturation.
Lastly , we did a meta-analysis of both stages under a fixed-effects model and used logistic regression to test for association in each stage.
Lastly , we do not know the proportion of female partners with diagnosed infertility.
Lastly , we examined the ability of GAO to cross the blood-brain barrier and determined it to be possible.
Lastly , we examined the associations between sleep quality / duration and verbal / non-verbal memory separately.
Lastly , we explain feed-forward relationship between Runx1 and Foxp3 and discuss roles of Runx1 in regulatory T cells ' suppressive activity.
Lastly , we highlight the numerous studies suggesting that sirtuins are efficacious therapeutic targets in neurodegenerative disease and injury.
Lastly , we highlight the usefulness of the Rhesus macaque model in studies related to the aging of the immune system.
Lastly , we identify aging-specific guidelines and service integration as important areas for future endeavors.
Lastly , we review the effects of healthy aging and recent evidence for a male-female difference with respect to exertional-related dyspnea.
Lastly , we shed light on the impact of aging processes on the regenerative capacity in the CNS of mammals and zebrafish.
Lastly , we used pathway analysis to determine whether relationships between single nucleotide polymorphisms and cognitive decline are mediated through AD pathology.
Lastly , we will close with some of the challenges that network methods face.
Last , menadione-induced superoxide generation was inhibited by AMPK pharmacologic activators and by overexpression of PGC-1α or FoxO3A.
Last , osteotendinous junction proximal displacement on average contributed with @number@ ( SD @number@ ) % of proximal myotendinous junction displacement.
Last , sarcoidosis is associated with autoimmune diseases , pulmonary embolism and malignancy ; however , the underlying mechanisms linking diseases continue to be debated.
Last updated : @date@ ( retrospectively registered ) .
Last , we review recent evidence indicating that targeting neuroinflammation may provide novel therapeutic avenues for AD.
Last , we will focus on the role of LCPUFA in most common neurodegenerative diseases like Alzheimer's disease and Parkinson's disease.
LA supplementation in animal models may prolong life , has neuroprotective effects and presents positive effects against cancer.
Latanoprost was first developed for use in glaucoma therapy as an ocular hypotensive agent targeting the prostaglandin F2α ( FP ) receptor.
LAT describes an intimate relationship wherein partners maintain separate households.
Late adulthood is associated with increased hippocampal atrophy and dysfunction.
Late AMD was detected in @number@ participants.
Late bilinguals , who learned English after age @number@ exhibited larger MMN and P3a responses than early bilinguals , across all deviant conditions.
Late complications can be appropriately treated when diagnosed early.
Late complications were identified in @number@ of @number@ patients who developed small granulomas.
Late development of UGT enzymes may contribute to chemical , drug , and environmental toxicity.
Late effects in normal tissues following radiotherapy vary across the age spectrum.
Late generation telomerase deficient mice exhibit signs of premature aging including reduced function of proliferating cellular compartments.
Late in the process , estrogen causes plaque erosion or rupture with subsequent thrombosis and acute coronary events.
Late-life depression ( LLD ) carries additional risk for suicide , medical comorbidity , disability , and family caregiving burden.
Late-life depression ( LLD ) is thought to be multifactorial in etiology , including a significant genetic component.
Late-life depression thus represents a new therapeutic target for the development of nicotinic agonist drugs.
Late-life depression was established using a Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition-based structured psychiatric interview.
Late-life depressive syndromes often arise in the context of predementia , dementia syndromes , and Alzheimer's disease ( AD ) .
Late-life development of affect may unfold terminal changes that are driven more by end-of-life processes and not so much by time since birth.
Late-life literacy ( reading comprehension and ability , writing ) was operationalized using confirmatory factor analysis.
Late-life performance was more affected by access difficulty than was early-life performance , with children's responses limited by lexicon size.
Lately , epigenetic regulation of gene expression was recognized for its impact on age-related OA pathogenesis.
Lately , many novel pathways , besides AMPK induction , have been revealed , which can explain some of metformin's beneficial effects.
Lately , the occurrence of spontaneous tendon ruptures or tendinosis have suggested a negative influence of statins upon tendon tissue.
Late mesh exposure was significantly more common in sexually active patients ( p = @number@ ) .
Late middle-aged participants demonstrated poorer performance than both other groups for all parameters.
Late middle-aged participants seemed to have focused on improvement of force amplitude , whereas young and early middle-aged focused on timing.
Late midlife physical health appeared to be a particularly salient mediator.
Latencies of the initial postural adjustment and foot liftoff varied depending on the number of postural adjustments made.
Latencies were discernibly longer in the LDT block where the PM targets were expected compared to the block where they were not expected.
Latency for cytomegalovirus is associated with more profound changes and the expansion of a unique pro-inflammatory , cytotoxic subset of CD4-positive CD28null T cells.
Latency served as the dependent measure.
Latent class analyses were conducted to identify the optimal social network typology based on @number@ indicators of interpersonal relationships and activities.
Latent class analysis ( LCA ) was used to place patients into homogeneous clusters.
Latent class analysis was used to identify groups of respondents based on types of professionals visited.
Latent class group analysis was used to identify six distinct trajectory classes of BMI z-score.
Latent class growth analyses revealed a three-class model for attention / executive function , four-class model for memory , and a three-class model for language.
Latent class growth analysis identified cognitive function trajectory groups , and multinomial logistic regression was used to examine the factors associated with group trajectories.
Latent class growth analysis identified @number@ trajectories.
Latent class growth models and logistic regression models were used to identify trajectory groups and their predictors , respectively.
Latent CMV infection , however , accelerates age-related changes in the T cell repertoire in elderly people under immunosuppressive therapy.
Latent content analysis was used.
Latent growth curve analysis was applied to characterize trajectories over the 42-year period.
Latent growth curve modeling was used to assess change in PA.
Latent growth curve modeling was used to estimate the change in HUI3 for each alcohol pattern after adjusting for covariates measured at baseline.
Latent growth curve models estimated VA and DS trajectories and age-adjusted associations between trajectories.
Latent growth curve models evaluated predictors of 10-year cognitive trajectories separately by training group.
Latent growth curve models examined the associations of age , education , and self-rated health with baseline levels and change trajectories in retrieval.
Latent growth curve models incorporated informative covariates ( baseline age , gender , self-rated health , education , and chronic conditions ) .
Latent growth curve models revealed sizeable spousal similarities not only in levels of happiness but also in how happiness changed over time.
Latent growth modelling was used for the longitudinal analyses.
Latent means in the partial invariant model were lower for the Dutch sample , compared to the Chinese sample.
Latent mixture modeling was used to identify trajectories in systolic , diastolic , and mid-BP over time.
Latent path analysis indicated that the bivariate associations between adjustment and wisdom and between generativity and wisdom were mediated by growth.
Latent profile analyses ( LPAs ) were estimated from these GIS-based measures.
Latent profile analyses were conducted to identify clusters of social network ties based on @number@ indicators.
Latent T. gondii infection may be of relevance to goal-directed behavior as it alters dopaminergic neural transmission.
Latent transition analysis was used to calculate the transition probabilities between adjacent visits.
Latent variable for cognition was constructed from word recall , animal naming , and letter search.
Latent variables corresponding to manual dexterity and executive functions were obtained using factor analysis.
Latent viral DNA is extrachromosomal , maintained as a circular episome bound to histones.
Late-onset Alzheimer's disease ( AD ) is an irreversible neurodegenerative disease of the elderly characterized by amyloid β ( Aβ ) plaques and neurofibrillary tangles.
Late-onset Alzheimer's disease ( AD ) is a sporadic disorder with increasing prevalence in aging.
Late-onset Alzheimer's disease ( LOAD ) is the most common cause of late-onset dementia in western societies.
Late-onset Alzheimer's disease ( LOAD ) is the most common form of dementia in the elderly.
Late-onset Alzheimer's disease ( LOAD ) is the most common neurodegenerative disorder in older adults , affecting over @percent@ of those over age @number@
Late-onset asthma is common , associated with poor outcome , underdiagnosed and undertreated , possibly due to the modifying effect of ageing on disease expression.
Late-onset hypogonadism is a clinical and biological syndrome associated with advancing age and characterized by typical symptoms and a deficiency in serum testosterone levels.
Late onset hypogonadism is a common condition in aging males.
Late-onset hypogonadism ( LOH ) is a clinical and biochemical syndrome associated with advancing age and characterized by typical symptoms of serum testosterone deficiency.
Late-onset hypogonadism ( LOH ) is a relatively common conditions affecting the aging male.
Late-onset Hypogonadism ( LOH ) syndrome has been established for a few years.
Late onset is a common hallmark character of numerous disorders including human neurodegenerative maladies such as Huntington's , Parkinson's and Alzheimer's diseases.
Late-onset male hypogonadism ( LOH ) is a clinical and biochemical syndrome associated with advancing age and characterised by low serum testosterone concentrations.
Late-passage , non-proliferating , myoblast cultures showed strong senescence-associated β-galactosidase activity indicating that the observed metabolic defects accompany the induction of a senescent state.
Late passage senescent cells already had higher HO-1 levels , and further induction of HO-1 by curcumin was considerably impaired.
Lateral brow position was significantly higher than the mid brow ( p < @number@ ) .
Lateral center of pressure ( CoP ) displacement from toe-off to MLM was also monitored to assess the risk of medio-lateral balance perturbation.
Laterality , reflected as right-ear preference for dichotic stimuli , was found to be increased in older age ( above @number@ years ) .
Lateralization patterns also differed.
Lateralized brain regions subserve functions such as language and visuospatial processing.
Laterally located center of gravity and higher excitation in the region adjacent to the core in weaker individuals could reflect compensatory recruitment of synergistic muscles.
Laterally , the loops are fixed under tension on the temporal fascia and the periosteum of the lateral orbital rim.
Lateral radiographs of the whole spine were taken for all subjects in the standing position.
Lateral rectus-superior rectus band degeneration with aging is the major cause of sagging eye syndrome , which usually presents with small-angle esotropia or hypotropia.
Lateral spatial interactions among elements of a scene , which either enhance or degrade visual performance , are ubiquitous in vision.
Later born cohorts of 75-year-olds are thus better equipped to maintain a non-age-related identity compared with earlier cohorts.
Later-born siblings have , on average , older parents than do first borns.
Later discovery and preexisting disease perhaps contributed to a shorter estimated survival time for older PLWHA and higher mortality.
Later examination of service levels revealed that profile changes were subsequent to modifications in service operating hours.
Later-exposed bilinguals showed greater recruitment of the prefrontal cortex relative to early-exposed bilinguals and monolinguals.
Later in @number@ resveratrol was reported to activate sirtuins in yeast cells.
Later life is also a period with enhanced exposure to critical life events , and this comes with risks.
Later life offers a unique opportunity for investigators to consider links between personality pathology and consequential outcomes in people's lives.
Later on , DMF stimulated p21 mRNA expression through a process dependent on p53 activity.
Later on , @number@ intervention and @number@ repeated studies were excluded.
Later parenting is considered by many to have advantages , parents-to-be may feel themselves more stable to rear children.
Later , participants were given a cued-recall test.
Later she complicated with cognitive decline and hallucinations.
Later , these patients demonstrated gene expression changes consistent with simultaneous , persistent pro-inflammatory and immunosuppressive states.
Later to mature in adulthood were major corticolimbic association tracts and connections at terminal gray matter sites in cortical and basal ganglia regions.
Later , we interviewed the staff geriatricians to analyse the Integrated Care Programme.
Late shunt failures included those in patients who had to undergo shunt revision more than @number@ years after their initial shunt insertion.
Late-stage age-related macular degeneration ( AMD ) is a common sight-threatening disease of the central retina affecting approximately @number@ in @number@ Caucasians.
Latest data suggest that the alkylating drug chlorambucil rather than fludarabine is a reasonable chemotherapeutic backbone for chemoimmunotherapy in these patients.
Late toxicity , quality of life , global response , time to progression and overall survival will also be estimated.
Lathosterol ( indicating cholesterol synthesis ) and sitosterol ( indicating cholesterol absorption ) also decreased with deteriorating health.
Latino and Caucasian women participate in different patterns of leisure activities.
Latinos did not differ from non-Hispanic Whites in the likelihood or number of falls.
Lattices with nonwrinkled-skin fibroblasts contracted uniformly by @percent@ after a three-day culture and the extract had little effect.
Laura has been featured in five psychotherapy training videos produced by the American Psychological Association.
Laura S. Brown , PhD , is a clinical and forensic psychologist in independent practice in Seattle , Washington.
Laura was also President of the Washington State Psychological Association.
LA uses in CVD and obesity , in humans , are controversial.
Lavender aromatherapy has the potential to ease anxiety in patients undergoing minimally invasive facial cosmetic procedures.
LA was defined with MRI.
LA was mainly tested in cardiovascular diseases ( CVD ) , obesity , pain , inflammatory diseases and aging.
Law enforcement officers suffer higher morbidity and mortality rates from all causes than the general population.
Laws and / or governmental policies regarding personal assistance and assistive devices did not always support participation in activities.
Layers of the SEM representing food and physical activity environments made smaller , but still significant , contributions to predicting children's weight status.
Laypersons and experts believe that wisdom is cultivated through a diverse range of positive and negative life experiences.
LBD , but not VBI , was positively associated with ADNC in both studies.
LB farms grow corn , rice , and tea while also raising pigs , fed with collected and cultivated fodder as well.
LBF was determined second-by-second by Doppler ultrasound , and central hemodynamics were measured by finger photoplethysmography.
L-BMD and baPWV were assessed at baseline and 12-month follow-up.
LBM T-scores were calculated on the basis of LBM in the young participants.
LBM was assessed by dual-energy X-ray absorptiometry ( DXA ) .
LBM was directly estimated ( eLBM ) in adults using an equation based on height and weight.
LBPs ameliorate the symptoms of mice with Alzheimer's disease and enhance neurogenesis in the hippocampus and subventricular zone , improving learning and memory abilities.
LBPs are reported to have antioxidative and antiaging properties in different models.
LBPs exhibit significant hypoglycemic effects and insulin-sensitizing activity by increasing glucose metabolism and insulin secretion and promoting pancreatic β-cell proliferation.
LBPs may potentiate the efficacy of lymphokine activated killer / interleukin-2 combination therapy in cancer patients.
LBPs protect the liver from injuries due to exposure to toxic chemicals or other insults.
LBPs show antitumor activities against various types of cancer cells and inhibit tumor growth in nude mice through induction of apoptosis and cell cycle arrest.
LBs were not significantly associated with number of falls , OR @number@ ( @number@.96-1.57 ) and @number@ ( @number@.82-1.48 ) .
LBs were not significantly associated with time to first fall , HR @number@ ( @number@.85-2.31 ) and HR @number@ ( @number@.72-1.62 ) .
LCA and latent class regression ( LCR ) were applied to identify classes of masticatory function and its potential determinants , respectively.
LCCSS patients had significantly lower DSCSA and SCCSA ( both P < @number@ ) .
LC damage is present in AD , multiple sclerosis , and a large number of other diseases and conditions.
LC did not change between HRT users and non-users in @number@ studies.
LCGM revealed three trajectories.
LC-MS analysis detected a difference in the ginsenoside content between normal white ginseng and enzyme-modified ginseng.
LC / MS analysis was used to quantify intracellular concentrations of β-hydroxybutyrate , carnitine , and l-lactate.
LC-MS / MS results confirmed that the lower molecular weight @number@ kDa and @number@ kDa proteins are related to the @number@ kDa SMP30.
LCPUFA are important for neuronal membrane integrity and function , and also contribute in prevention of brain hypoperfusion.
LCSS patients had significantly higher LFA ( P < @number@ ) and LFT ( P < @number@ ) .
LD-1227 brought about also a more significant downregulation of the tested cytokines cascade.
LD-1227 or placebo ( water-soluble starch ) were given daily at breakfast and dinner for three months.
LDL and HDL subfractions were analysed in serum with the use of Lipoprint system.
LDL-C < 130 mg / dL ( @number@ mmol / L ) was defined as \ "optimal / near optimal \ ".
LDL-C , total cholesterol , systolic blood pressure and waist size were found to decrease during R6 treatment.
LDL-C was controlled to the guideline target in @percent@ of those with CVD and @percent@ of those with diabetes.
LD muscles were aged for @number@ @number@ @number@ and @number@ days and were then evaluated for quality index.
LDS was smaller in UP conditions.
Leaders are critical to motivating clinicians and stakeholders in the review process.
Leading a lonely life is associated with the use of psychotropic drugs among retired people ( OR = 1.7 ) .
Leading research groups provide critical reviews of the current knowledge and propose future directions for this evolving field.
Leading telomere processing remains incomplete until late S / G2 , when the C-terminal nucleotide is specified-referred to as the late phase.
Leading theories implicate peripheral monocyte HIV DNA reservoirs as a mechanism for spread of the virus to the brain.
Lead malfunction is a common problem in implantable cardiac device patients and is expected to increase with the aging of leads.
Lead overshoot progressively increased with advancing age.
Lead variants in four of the novel loci are non-synonymous variants in the genes C10orf71 , DALDR3 , TESK2 and SEC31B.
Leakage of cathepsins from lysosomes , due to their membrane permeability , and activation of pro-apoptotic factors additionally contribute to neurodegeneration.
Leaks around vessels other than the DMCA were more frequent in older transgenics compared with younger ones.
LE , ALE and LE / LE among the hypertensives with cardio-cerebral vascular diseases were shorter than the hypertensives without the disease.
Lean body mass appears to provide the best prediction of subsequent development of osteoporosis.
Lean body mass ( LBM ) is important to maintain physical function during aging.
Lean mass and fat mass were secondary outcomes.
Lean mass at the midthigh region of the trained leg increased by @percent@ ± @percent@ ( P < @number@ ) after the intervention period.
Lean mass correlated positively with 1α , 25 ( OH ) 2D3 ( rho = @number@ p = @number@ ) , in women.
Lean mass decreased , whereas leptin increased with increasing tertile.
Lean mass , vastus lateralis myofiber-type-specific cross-sectional area , satellite cell content , and myonuclear addition were assessed before and after resistance training.
Lean mass was the strongest independent factor associated with BMD at all sites among men and women.
Learner feedback emphasized the importance of enthusiastic and well-prepared faculty , interactive learning experiences , and engagement in relevant work.
Learning about patient experiences may help new physicians appreciate the experiences of transitions on patients.
Learning about the death by walking into a room to find the bed empty or already filled was the most negative experience.
Learning and memory are cognitive processes that are tightly regulated.
Learning and memory processes critically involve the orchestrated regulation of de novo protein synthesis.
Learning and memory task performance were impaired in Arg-61 mice at both old and young ages compared with C57BL / 6J mice.
Learning disability might confer vulnerability of this network to early-onset , focal Alzheimer's pathology.
Learning from repeat testing , or practice effects , can mask the decline in younger cohorts.
Learning gaps , preferences , and potential inequities were identified.
Learning healthcare systems facilitate diffusion of innovation while enabling rigorous evaluation of effects on patient outcomes.
Learning how to gain rewards ( approach learning ) and avoid punishments ( avoidance learning ) is fundamental for everyday life.
LEARNING OBJECTIVES : After studying this article , the participants should be able to : @number@
LEARNING OBJECTIVES / OUTCOMES : After participating in this educational activity , the participant should be better able to : 1.
Learning rates for participants over @number@ were half those of younger participants.
Learning was assessed using an established object-location paired-associative learning paradigm.
Learning was indicated by faster and more accurate responding to these high-probability targets than to low-probability targets.
Leave-one-out experiments result in statistics on differences between actual and predicted observations.
Leaving one's home more frequently predicted an increase in carotenoid levels and attending fewer activities predicted a decrease in carotenoid levels.
Leber hereditary optic neuropathy is a well-known mitochondrial disorder that leads to bilateral subacute visual failure.
Lectin blotting was used to confirm DSA-FACE results.
Lectures based on the GEMC can be a high-yield tool to enhance resident knowledge of geriatric emergency care.
Left and right cerebellar GMv and WMv , and M1v were obtained using FreeSurfer.
Left- and right-lateralized hubs formed two separable networks of mutually lateralized regions.
Left and right sides were analyzed separately.
Left atrial enlargement was defined as iLA > or = 35.7 and > or = 33.7 ml / m in men and women , respectively.
Left atrial ( LA ) structural and functional abnormalities are vital steps on the pathway toward heart failure with preserved ejection fraction in asymptomatic patients.
Left atrial volume was determined by standardized echocardiography at baseline and again after @number@ years.
Left atrial volume was indexed to body height ( iLA ) .
Left frozen hemispheres of @number@ neuropathologically confirmed AD patients were regionally dissected.
Left grip strength / left mid-arm muscle circumference shows a pattern across age similar to strength / mass in both sexes.
Left-handedness has been described as a proxy for atypical brain hemispheric lateralization.
Left hemispheric dominance regarding the FA and diffusivity indices was demonstrated in uncinate fasciculus with no significant gender-related differences.
Left HV correlated with CSF tau ( R = @number@ ) and P-tau ( R = @number@ ) levels.
Left-right SRTs varied over more than @number@ dB , while front-back SRTs varied over more than @number@ dB.
Left , right , total lung and heart dose-volume and dose-mass parameters along with clinical , disease and treatment-related characteristics were analyzed.
Left ventricle s ' wave velocity was higher in men than in women.
Left ventricular assist devices ( LVADs ) are an effective therapy for a growing and aging population in the background of limited donor supply.
Left ventricular ejection fraction ( LVEF ) was assessed by echocardiography.
Left ventricular ejection fraction must be determined to assess prognosis and guide therapy.
Left ventricular ejection fraction must be obtained to classify patients into systolic and diastolic HF and to guide evidence-based therapy.
Left ventricular endocardial action potentials were simulated using a modified Luo Rudy model.
Left ventricular hemodynamics are increasingly recognized as important contributors to risk for sudden death.
Left ventricular hypertrophy due to hypertension represents a major risk factor for adverse cardiovascular events and death.
Left ventricular mass index ( LVMI ) and left ventricular hypertrophy ( LVH ) were assessed using echocardiography.
Left ventricular outflow tract obstruction at rest , use of diuretic and average dose of diuretic were higher in patients over @number@ years old.
Left ventricular structure and function were assessed by 2-dimensional and speckle-tracking echocardiography.
Left ventricular twist was analyzed as apical rotation relative to the base in the 3D coordinates.
Leftward volume asymmetry of the planum temporale and leftward FA asymmetry of the arcuate fasciculus were simultaneously demonstrated.
LEF was assessed by the Short Physical Performance Battery.
Leg extension power increased significantly in both legs ( P < @number@ ) , with no difference observed between legs.
Leg extension power ( watts ) was measured as an index of muscle function.
Leg extensor force ( torque ) , but not maximal contraction velocity , was significantly associated with muscle power in MH.
Legislative and policy changes targeted at requiring this type of cultural competency training for all direct service providers are considered.
Leg lean mass was assessed by dual energy X-ray absorptiometry in Years @number@ @number@ @number@ @number@ @number@ @number@ and @number@
Leg LM index increased ( @number@ ± @percent@ , P < @number@ ) after WBVT + L-citrulline compared with L-citrulline.
Leg press and leg extension of 1RM were measured at baseline and post intervention and before the first training session in weeks @number@ and @number@
Leg strength , serum [ 25 ( OH ) D ] and physical activity levels were measured.
Leg strength was not significantly different between visits ( p > @number@ ) .
Legume consumption was also positively associated with SUArate within the GRStotal's lowest tertile.
Leisure accounted for the significant increase , while health management and social connections activities increased modestly.
Leisure-time physical activity and different types of sedentary behavior were assessed with the Modifiable Activity Questionnaire.
Leisure-time physical activity , predominantly consisting of endurance type exercises , was not related to LBM in this group.
Lemon ( Citrus limon ( L. )
Length / height variables were associated with vertebral size only before including adult height in the models , and became non-significant thereafter.
Length of hospitalisation , mortality and adverse effect data were also analysed.
Length of HT use was not associated with TL or telomerase activity in this study.
Length of stay data were collected from medical records after discharge.
Length of stay decreased @number@ days.
Length of stay , number of diagnoses and of medications , readmission and mortality were assessed.
Length of stay was between @number@ and @number@ days.
Length of the vocal folds and distance from the valleculae to the vocal folds were significantly affected by gender ( P < @number@ ) .
Length of time on HT was the measure used for duration of exogenous estrogen exposure.
Lengths and diameters of each aortic segment as well as width , height and tortuosity of the thoracic aorta were compared between both genders.
Lengths of stay amongst fallers and the malnourished were assessed.
Lens density was assessed using a validated psychophysical technique.
Lens epithelial cell apoptosis is regarded as the common molecular basis of the initiation and subsequent progression of cataract.
Lens evaluations were performed at the second test using the Lens Opacities Classification System III.
Lens opacification or cataract reduces vision in over @number@ million people worldwide and blinds @number@ million.
Lens opacities or cataract ( s ) represent a universally important cause of visual impairment and blindness.
Lens opacities were measured according to the Lens Opacities Classification System III ( LOCS III ) .
Lens thickness decreases with the growth of the eyeball.
Lens transparency might be associated with longer LTL in community-dwelling older adults and should be investigated further as a possible biomarker of aging.
Lens transparency , or the magnitude of cataract severity , is a potential in vivo marker of aging distinguishable from diagnosed cataract.
Lenticular AF intensity correlated well with lens density indices estimated from psychophysical measures.
Lenticular AF was positively correlated with age ; however , there could also be large differences between individuals of similar age.
Lentinus edodes , commercial obtained in daily life , had recently become more attractive in physiological research.
Lentiviral complementation with wild-type MDH2 cDNA restored MDH2 levels and mitochondrial MDH activity.
Leptin , adiponectin , and total ghrelin play important roles in energy homeostasis and are suggested to be biomarkers of metabolic disturbances.
Leptin , an anorexigenic hormone in the hypothalamus , suppresses food intake and increases energy expenditure.
Leptin and the Human Placenta Lactogen were assayed using the Sandwich-ELISA technique.
Leptin , but not adiponectin , was negatively correlated with ferritin ( p = @number@ r = @number@ ) .
Leptin is a circulating hormone / cytokine with central and peripheral effects that is released mainly by subcutaneous white adipose tissue.
Leptin ( LEP ) significantly affects metabolism and numerous functions of the organism.
Leptin levels were similar among nutritional state groups.
Leptin may provide additional mortality discrimination in obese men.
Leptin , progesterone and FBG were significantly increased in those who developed GDM.
LEP was found to be associated with decreased prolonged length of stay ( OR = 0.35 ; P = 0.01 ) .
Lercanidipine / enalapril is a promising example of a fixed-dose combination of these drug classes.
Lesbians more frequently identified the break-up of a relationship and occupational and educational related experiences as turning points.
Lesbians of all ages must raise their awareness of the harm done by ageism and actively combat it.
Lesion growth was calculated as percentage of mismatch tissue that underwent infarction on follow-up ( percentage mismatch lost ) .
Lesion specificity was similar between Original and Condensed Protocols.
Lesion studies link the prefrontal cortex ( PFC ) to executive functions.
Lesions were classified as CMI or nonCMI based on histology , and their MR features were recorded.
Lesions were detected in stage II in posterior mandible with no clear trigger agent.
Lesions were evenly and repeatedly scanned with both wavelengths until light pain or purpura presented.
Lesions were segmented on fluid-attenuated inversion recovery images.
Less activity in the left caudate was associated with semantic integration deficits in PD.
Less attention has been given to system capacity to provide community alternatives to LTC ( supply-side factors ) .
Less attention has been paid to alternative mechanisms , including parental socio-demographic characteristics or the timing of parental death.
Less attention has been paid to future perceptions in older adults whose future is temporally limited.
Less attention has been paid to the fact that several disorders of the skin are linked to alterations of mitochondrial energy metabolism.
Less attention has been paid to the non-immune factors that may maintain the pool of naïve CD8 T cells.
Less attention has been placed on factors associated with long-term maintenance of intact cognition even into very old age.
Less attention is given to the choice of statistical techniques that are used to test the hypotheses associated with the data.
Less certain is the role of HMB supplementation in reducing fat mass and , thus , in the treatment of sarcopenic obesity.
Less commonly , sclerotic PD was also found which is perhaps the most difficult to evaluate given its broad differential.
Less common were notifying a nurse ( @number@ ) or documenting in behavior log ( @number@ ) .
Less consistent are the findings that pertain to the relationship between elevated brain iron content and systemic indices of vascular and metabolic dysfunction.
Less documented are reproductive effects for mercury , manganese , chromium , nickel , and arsenic for the same gender.
Less educated grandparents might be more exposed to and might be less able to cope with stressful aspects of grandparenthood than their better educated counterparts.
Lesser effects are flattening of the normalized stimulus response curve and reduction in threshold change following strong hyperpolarizing currents.
Less evidence exists regarding the effectiveness of such exercises to improve metabolic risk factors for age related conditions.
Less information is available on morphological and functional changes in tissue occurring as a result of NAFT.
Less interest in a surgical career was seen among female ( P = 0.001 ) and older students ( P = 0.017 ) .
Less is known about deficit accumulation in China , the country with the world's largest number of older adults.
Less is known about social determinants , which may have different impacts on quality of life in men and women.
Less is known about the burden of calcified subclinical atherosclerosis and cognition , especially in midlife.
Less is known about the epigenetic role that nutrients have in directly influencing longevity and aging.
Less is known about the influence of age and FMR1 gene expression on executive control and postural stability in females with the PM.
Less is known about their functional organization in short-term memory ( STM ) .
Less is known about their long-term effects on skin rejuvenation and neocollagenesis.
Less is known about the relationship between MetS and cognition.
Less is known about the role of social networks in this relationship.
Less is known about the utility of this approach in populations at different latitudes , and whether it relates to skin cancer risk.
Less is known about this association in patients with HF with preserved ejection fraction ( HFpEF ) .
Less is known , however , about the association between frailty and bone health.
Less is known regarding clinical and subclinical depressive symptoms over time and risk of disability and mortality.
Less is known regarding the burden of cardiovascular disease attributable to reduced GFR.
Less numerate middle-aged and older adults , however , showed less influence of numeric format on willingness to take the medication.
Less often discussed is specifically how end-of-life care can and should be provided , by whom , and with what resources.
Less often studied are the characteristics of trainees that benefit most from training.
Lessons can be gleaned from studying fields related to plasticity , such as development , critical periods , learning and response to disease.
Lessons gleaned can inform the effective use of technology-enabled dietary assessment tools in research.
Lessons learned are applicable to the implementation of other chronic-disease care models aimed at improving the primary care management of complex chronic conditions.
Lessons learned from practice experiences of social workers working in hospice and palliative care can inform educational efforts of all professionals.
Lessons learned from preclinical and clinical therapeutic studies are discussed.
LESSONS LEARNT : The framework can be used to build local capacity on evidence-informed policy-making.
LESSONS : The findings indicate that diabetes mellitus may have an impact on the severity of HNPP.
Less regular exercisers had increased odds of all outcomes , particularly locomotor disability.
Less research has been directed towards non-pharmacological treatments.
Less severity was noted at @number@ months than at baseline.
Less strong correlations between symptoms and metabolites suggest a healthier situation after R6 treatment.
Less than a third of the sample ( @number@ % ) was aware of the existence a judicially appointed guardian for patients affected by dementia.
Less than half felt that economic status and community had great impact.
Less than one in four patients regularly used analgesic medications postsurgery.
Less than one-quarter of studies of physician-elderly patient communication even mention that hearing loss may affect communication.
Less than one quarter of women reported taking calcium supplements and only @percent@ reported taking vitamin D supplements.
Less than @percent@ of anti-PD medication was given within ±1 h of the scheduled time.
Less than @percent@ of HF-related sessions in conference proceedings mentioned palliative care.
Less than @percent@ of men and women reported no metabolic symptoms or symptoms related to the head.
Less than @percent@ of the infrared spectral range was used in the previous studies to demonstrate differences.
Less than @percent@ of the participants had a total free recall score below @percent@ correct.
Less than @percent@ of the patients received some form of training by health professionals.
Less than @percent@ of the tests were not completed.
Less than @percent@ of women < 50 years had values > 100 μg / l.
Less then @percent@ of the cases were diagnosed in adolescents , @percent@ above @number@ years of age and only @percent@ above @number@ years.
LEs with each state by sex and country were calculated using Sullivan's method.
Let-7 family members Let-7b and Let-7e were significantly elevated and further validated in older subjects ( P < @number@ ) .
Lethality rates increased from mean @percent@ to @percent@ , the highest rates registered in those @number@ years or older.
Letter fluency correlated with FBI and cognitive tests.
Leucine coingestion has been reported to stimulate postprandial insulin release and augment postprandial muscle protein accretion.
Leucine modulates muscle protein synthesis ( MPS ) , with potential to facilitate accrual / maintenance of muscle mass.
Leucine-rich repeat kinase @number@ ( LRRK2 ) is a causative gene of autosomal dominant familial Parkinson's disease ( PD ) .
Leucine-rich α2-glycoprotein ( LRG ) is a protein induced by inflammation.
Leucine supplementation has been proposed as a possible strategy because of its regulatory role on protein homeostasis.
Leucine supplementation has grown in popularity due to the discovery of its anabolic effects on cell signaling and protein synthesis in muscle.
Leucocytes were sparsely defined ( @percent@ ) .
Leukemia is a type of malignant hematopoietic tumor in hematopoietic stem cells.
Leukemic transformation is initiated by specific genomic alterations that impair apoptosis of clonal B cells.
Leukocyte chemotaxis and NK cell activity are significantly impaired in septuagenarians compared with young people whereas centenarians maintain them.
Leukocyte counts were measured and the presence of moderate to severe WMLs was determined by brain MRI.
Leukocyte telomere length ( LTL ) and bone mineral density ( BMD ) are associated with health and mortality.
Leukocyte telomere length ( LTL ) has been observed to be hereditable and correlated with longevity.
Leukocyte telomere length ( LTL ) is a marker of replicative ageing.
Leukocyte telomere length ( LTL ) is a predictor of aging and a number of age-related diseases.
Leukocyte telomere length ( LTL ) is considered as the marker of biological aging and may be related to environmental factors.
Leukocyte telomere length ( LTL ) shortens with age.
Leukocyte telomere length ( LTL ) was measured using Southern blot analysis.
Leukocyte telomere length ( LTL ) was measured with the use of quantitative real-time polymerase chain reaction.
Leukocyte telomere length ( TL ) , an aging marker , is associated with age-related and chronic pathologies , including schizophrenia.
Leukocyte telomere length was assayed from DNA specimens.
Leukocyte telomere length was determined by a quantitative real-time PCR method.
Leukocyte telomere length was measured at the time of mental stress testing and @number@ years later.
Leukocyte telomere length was not significantly related to hippocampal volume in either group ( @number@ unmedicated MDD subjects and @number@ healthy controls ) .
Leukocyte TL , expressed in base pairs ( bp ) , was determined in fasting blood samples by performing quantitative polymerase chain reaction.
Level of caregiver distress was also significantly associated with days of nurse visits ( β = -.66 , p = .028 ) .
Level of depressive symptoms was not affected.
Level of distress was measured with the Delirium Experience Questionnaire.
Level of education and cognitive reserve assessment in neuropsychological testing deserve attention , as well as cultural , social , and economic aspects of caregiving.
Level of education , income , and residence in the Western states significantly correlated with higher scores.
Level of education varied from primary school to university , with almost half of them holding a bachelor's degree or higher.
LEVEL OF EVIDENCE : 2b.
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LEVEL OF EVIDENCE : Epidemiologic study , level III.
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LEVEL OF EVIDENCE : III , prospective case-control study.
LEVEL OF EVIDENCE III : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE III : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE I : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE : IV.
LEVEL OF EVIDENCE IV : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE IV : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE IV : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE IV : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE IV : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE IV : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE IV : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE IV : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE IV : This journal requires that authors assign a level of evidence to each article.
LEVEL OF EVIDENCE : Level II , comparative cohort study.
LEVEL OF EVIDENCE : Level III , comparative series.
LEVEL OF EVIDENCE : Level III , prognostic study.
LEVEL OF EVIDENCE : Level II , therapeutic study.
LEVEL OF EVIDENCE : Level IV , prognostic study.
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LEVEL OF EVIDENCE : @number@ Technical Efficacy : Stage @number@ J. MAGN.
LEVEL OF EVIDENCE : @number@ Therapeutic.
LEVEL OF EVIDENCE : Prognostic study , level II.
LEVEL OF EVIDENCE : Prognostic study , level III.
LEVEL OF EVIDENCE : Therapeutic Level IV.
LEVEL OF EVIDENCE : Therapeutic Level IV.
LEVEL OF EVIDENCE : Therapeutic study , level III.
LEVEL OF EVIDENCE V : This journal requires that authors assign a level of evidence to each article.
Level of exercise participation was measured at baseline ( @number@ ) and cognitive impairment status was measured at baseline and 5- and 10-year follow-up.
Level of knowledge about sexuality was not associated with attitudes.
Level of need and cognitive status partially explained the associations.
Level of social engagement was not associated with patterns of decline across time in cognitive or physical health.
Level of social engagement was significantly associated with memory , mental status , and self-reported health.
Level of type I collagen was assessed by enzyme-linked immunosorbent assay.
Levels and the kinds of food intolerance were associated with age , sex and appeared a linear correlation tendency ( P < @number@ ) .
Levels of all apolipoproteins except ApoH were higher in females.
Levels of antibiotic prescribing were also assessed.
Levels of ARIH2 mRNA are regulated by PABPN1 via proximal polyadenylation site usage.
Levels of catecholamines and LF significantly decreased following yogic practice.
Levels of cJun and JunB proteins , components of the transcription factor AP-1 complex , were also elevated.
Levels of depression are similar between nonmigrants and migrants relocated for infrastructure projects , poverty alleviation , or disaster management.
Levels of disability were generally lower in Eastern Europe , followed by England and Southern Europe and lowest in Northern and Western Europe.
Levels of eleven pro- and anti-inflammatory markers were assessed by immunohistochemistry in normal breast tissue obtained from @number@ pre- and postmenopausal breast cancer patients.
Levels of evidence and grades of recommendation were determined according to guidelines of the Oxford Centre for Evidence-Based Medicine.
Levels of evidence - IV.
LEVELS OF EVIDENCE : Therapeutic , Level II.
LEVELS OF EVIDENCE : Therapeutic , Level IV : Case series.
Levels of evidence were assigned to each study using a modified Sackett scale.
Levels of evidence were assigned to the study design using a modified Sackett scale.
Levels of extractable and protein-bound HHE were increased in multiple regions in the progression of Alzheimer's disease ( AD ) .
Levels of Galectin @number@ increase in the MSC of aging mice and perhaps this contributes to the development of cancer in the elderly.
Levels of GP serotonin transporter binding correlated positively with severity of dyskinesias.
Levels of happiness did not vary with age.
Levels of HSP72 , PRX5 , and eNOS were significantly higher in quiescent muscle of older compared with younger subjects , irrespective of training status.
Levels of IFN-γ , IL-17 , IL-10 , IL-1β , and TNF-α were higher in patients with active intestinal BD than those in healthy controls.
Levels of IgA , IgG1 and IgG4 antibodies to beta-lactoglobulin and alpha-casein were measured using ELISA.
Levels of IGF-I are nutritionally regulated and are therefore modifiable.
Levels of inhibitory functioning were negatively associated with intention interference in the older adult group , but not in the younger adult group.
Levels of job control and demands over the whole working life were assessed by a validated matrix.
Levels of melatonin , or circadian rhythms dysregulation might play a crucial role in the above associations.
Levels of miR-146a were significantly decreased in CSF of AD patients.
Levels of mRNAs were determined for p53 , p21 , p53R2 , and mdm2.
Levels of MTs decrease with aging and disease , which may result in zinc release that is potentially cytotoxic.
Levels of NAA , creatine and choline in anterior cingulate cortex , cerebellum , striatum and dorsolateral prefrontal cortex were measured with magnetic resonance spectroscopy.
Levels of overall filial discrepancy divided older adults into four groups based on the medium value of filial expectations and receipt.
Levels of physical activity decreased progressively with age , with greater decline among women.
Levels of physical activity were significantly higher in this group.
Levels of regular / non-regular PA were based on ≥ @number@ h of weekly exercise.
Levels of T and ABP in serum were measured using chemiluminescence immunoassay ( CLIA ) and enzyme-linked immunosorbent assay ( ELISA ) respectively.
Levels of TauΔCasp6 in CSF accurately reflected the levels of active Casp6 and TauΔCasp6 detected using immunohistochemistry in hippocampal sections from the same individuals.
Levels of telomerase activity can be an indicator of the proliferative potential of somatic cells and may serve as a diagnostic biomarker of malignancy.
Levels of TGF-β1 were measured by ELISA in sera from @number@ patients undergoing coronary artery bypass grafting ( CABG ) .
Levels of TGF-β were quantitatively evaluated using computerized image analysis of immunostained sections.
Levels of the collagenases MMP-8 and MMP-13 were insignificant and neither MMP-2 nor MMP-14 were associated with increased collagen degradation.
Levels of the pathogenic m.3243A > G tRNA mutation were also found to increase with age.
Levels of the SPM lipoxin A4 ( LXA4 ) were reduced in AD , both in the CSF and hippocampus.
Level-specific analysis indicated high mortality risk with only markedly anticholinergic ( ADS level @number@ ) medication use ( OR @number@ @percent@ CI @number@.42-1.51 ) .
Levobunolol hydrochloride solution is an effective therapy for ocular hypertension , probably by reducing aqueous fluid production.
Levodopa ( LD ) is the most effective drug to treat the symptoms of Parkinson's disease ( PD ) .
Levofloxacin-based triple therapy is also a promising alternative after failure of \ "sequential \ " and \ "concomitant \ " therapies.
Lewy bodies and macroscopic infarcts were associated with all domains , while microscopic infarcts had more limited associations.
Lewy bodies and neurites are the pathological hallmark of Parkinson's disease.
Lewy bodies , the characteristic neuropathological lesions found in the brain of PD patients , are composed mainly of α-synuclein protein.
Lewy bodies were identified with antibodies to alpha-synuclein and classified as nigral , limbic , or neocortical based on their distribution in @number@ brain regions.
Lexical memory and Bergen dichotic listening tests were performed.
Lexical retrieval in production is a competitive process , requiring activation of a target word from semantic input and its selection from amongst coactivated items.
Leydig cells showed focal hyperplasia without extensive trend related with ageing.
Leydig cell testosterone ( T ) production is reduced with age , resulting in reduced serum T levels ( hypogonadism ) .
LF1 primarily reflected traits from the pulmonary and physical activity domains.
LF-SQ cream enhanced the skin moisture and the anti-wrinkle formation.
LFS responder rates exceeded @percent@ through @number@ year with VYC-15L.
LF thickness at all levels increased significantly with age ( P < @number@ ) .
LGP-HA and LGP-HA + L were generally well tolerated in all Fitzpatrick skin types.
LH elevation seems to be secondary to hyperandrogenemia and is absent in the most obese cases.
LHFPL2 was also positively correlated with age in peripheral blood ( p value = @number@ × 10 ( @number@ ) ) .
LH levels were higher in SA than WE men in age-adjusted and fully adjusted models.
Licence restrictions represent a possible third option for some older drivers , by better managing crash risk while still allowing acceptable levels of mobility.
License prevalence was modeled using a logit model.
LiCl enhanced the production of IL-10 in LPS stimulated young DCs.
LiCl had no significant effect on PAM3CSK4 responses in aged and young DCs.
LiCl treated DCs also displayed differences at the level of CD4 T cell priming and polarization.
Lidocaine and extrusion through a 30-G needle exerted no influence on HA structure.
Lidocaine had no apparent effect on morphology ; extrusion through a 30-G needle had no effect on ultrastructure.
Life and death are exquisitely regulated at the cellular level from development through maturity.
Life and health span can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction.
Life course events and the social construction of sexuality lead older widows to reflect upon their sexuality.
Life course influences are demonstrable , but complex.
Life Course Path Analyses were used to obtain effect estimates of the rates of gain on the offspring's BMI.
Life course SEP was assessed by multiple methods.
Life-course socio-economic disadvantage , as accrued during childhood and adulthood , included measures of paternal education and occupation and participant's education and occupation.
Life expectancies have increased dramatically over the last @number@ years , affording greater opportunities to study the impact of age on adult craniofacial morphology.
Life expectancy at the turn of the 20th century was @number@ years on average worldwide and it is around @number@ years today.
Life expectancy continues to rise.
Life expectancy for people with haemophilia ( PWH ) has improved and is now approaching that of the general population.
Life expectancy has always been associated to several determinants , such as environmental and genetic factors.
Life expectancy has increased considerably throughout the world.
Life expectancy has increased in many countries as a result the world's population is aging.
Life expectancy is rising however with more people living longer there is a concomitant rise in the incidence of dementia.
Life expectancy should be determined by the two standard Gompertz parameters and also by the single parameter in the model c / x.
Life expectancy should therefore be incorporated in decision-making for preventive services.
Life expectancy will continue to increase , but the differences between socioeconomic groups will not become smaller.
Life history theory links human physical and sexual development to longevity.
Life is stressful.
LifeLines contains information on biochemistry , medical history , psychosocial characteristics , lifestyle and more.
Lifelong anorgasmia may suggest the patient is unfamiliar or uncomfortable with self-stimulation or sexual communication with her partner.
Lifelong bilingualism is associated with the delayed diagnosis of dementia , suggesting bilingual experience is relevant to brain health in aging.
Lifelong nutrition may be of importance in the prevention of CHD in older women.
Life-long regular endurance exercise is known to counteract the deterioration of cardiovascular and metabolic function and overall mortality.
Life-long regular endurance runners ( master athletes ) had a @number@ % lower AGE cross-link density compared to old untrained.
Lifelong spontaneous exercise significantly retards frailty.
Life-prolonging effects of caloric restriction are in part due to reduction in IGF-1 , insulin , and glucose levels.
LIFE randomized @number@ sedentary men and women aged @number@ to @number@ years to a moderate-intensity physical activity ( PA ) or health education program.
Life-review therapy is an evidence based treatment of depression in older adults.
Life satisfaction decreased as the frequency of the participants ' visits to Turkey and years of living in Sydney increased.
Life satisfaction increased over the years even though objective health factors decreased.
Life satisfaction was self-reported with Cantril's ladder.
Life-space also contributes separately to fall risk.
Life-space assessment ( LSA ) during the past @number@ weeks was assessed during in-home interview.
Life-space assessment may assist clinicians in identifying older adults at risk of short-term mortality.
Life-space mobility was assessed annually with the Life-Space Assessment ( range 0-120 , higher scores indicate better life-space mobility ) .
Life-space was measured at each interview using the UAB Life-Space Assessment , a validated instrument for assessing community mobility.
Lifespan development and aging do not take place in a vacuum.
Life-span development is inherently linked to the perception of time and associated temporal construals.
Life span extension has been a goal of research for several decades.
Life-span extension was associated with increased reproduction and higher expression of oxidative stress and heat shock response genes.
Lifespan is a complex trait , and longitudinal data for humans are naturally scarce.
Life span is determined by a complex sequence of events leading to organismal senescence , and ultimately death.
Lifespan is influenced by a large number of conserved proteins and gene-regulatory pathways.
Lifespan , longevity and healthy aging are complex phenotypes , and unravelling of the genetic background has been challeng-ing.
Lifespan perspectives and the brain-behavior relationship are integrated and applied to geropsychological models.
Lifespan perspectives have played a crucial role in shaping our understanding of many forms of psychopathology.
Life-span predictions are supported by quantitative and qualitative empirical observations and offer theoretical frameworks for future experimental designs and data analyses.
Life span-prolonging effects have also been observed in yeast cells , nematodes and flies upon the overexpression of Sirtuin-1.
Life spans are increasing and research is showing more and more how important exercise is to successful aging.
Life span showed both positive association and genetic correlation with reproductive history factors.
Lifestyle activities were measured in multiple domains of engagement ( e.g. , cognitive , physical , and social ) .
Lifestyle and behavioral changes may provide benefit in some individuals , but for many cases , pharmacotherapy is the best option.
Lifestyle and dietary factors seem to be related to risk of mortality in middle-aged women.
Lifestyle and health information was collected by questionnaire.
Lifestyle and multivascular imaging data along with clinical covariates were collected from @number@ participants.
Lifestyle and wealth were recognised as staple features of the popular image.
Life-style change is a method that could achieve such a goal with relatively good reproducibility and low cost.
Lifestyle changes including moderately decreased caloric intake and aerobic exercise could prevent proatherogenic changes and weight gain observed with aging.
Lifestyle factors of skin care were evaluated by a self-administered questionnaire.
Lifestyle factors such as smoking , excessive alcohol use , and poor diet modulate susceptibility to dementia in both males and females.
LIFESTYLE FACTORS : The strategies are to encourage regular physical and mental exercise in midlife and in late-life.
Lifestyle habits must be encouraged , including healthy diet and exercise.
Lifestyle has a primary role among non-genetic factors affecting health and lifespan.
Lifestyle information was obtained by a questionnaire at the same time , and genomic DNA was isolated from peripheral leukocytes.
Lifestyle interventions introduced early in cancer care are both safe and feasible.
Lifestyle interventions need to be initiated early in cancer care to prevent the early onset of obesity and cardiovascular disease ( CVD ) .
Lifestyle issues such as sexual dysfunction may be exacerbated by the medical issues and psychological problems associated with haemophilia.
Lifestyle modification is the basis of diabetes treatment.
Lifestyle modifications are a conjunct of daily activities that can be managed to have the lowest interference on the functioning of the urinary tract.
Lifestyle modifications are particularly effective in preventing diabetes in this age group.
Lifestyle patterns may constitute a new research and public health perspective.
Lifestyle-related factor is one of the key preventative measures.
Life table analyses reveal that subjects spent over half of the period after @number@ with serious functional limitations.
Life tables and population data were also obtained for each country.
Life-threatening hemorrhage of the bilateral IMA system occurs even in LeFort I fractures.
Lifetime alcohol consumption negatively correlated with frontal white matter integrity in the AUD group ( rs = @number@ - @number@ ) .
Lifetime and 12-month use of psychotropic medications was @number@ and @percent@ , respectively.
Lifetime blindness and costs were @number@ years and € @number@ ( strategy @number@ ) and @number@ years and € @number@ ( strategy @number@ ) .
Lifetime intellectual enrichment might delay the onset of cognitive impairment and be used as a successful preventive intervention to reduce the impending dementia epidemic.
Lifetime IPV prevalence , types , and duration were calculated.
Lifetime life events and their subjective impact were assessed using a validated questionnaire.
Lifetime occupational noise exposure was a risk factor especially for the low-frequency hearing threshold PTA4.
Lifetime or current subsyndromal symptoms of depression at baseline did not increase the risk of incident MDD.
Lifetime psychological health was identified from child and adult measures.
Lifetime risk of THR was calculated for @number@ and @number@ using registry , life table , and population data.
Lifetime SA was reported by @percent@ of respondents.
Lifetime variability is dominantly driven by associative change in the least well-connected words.
Lifting-years , but not the other mechanical exposures , were associated with risk of disability pension ( HR @number@ @percent@ CI @number@ @date@ ) .
Ligands do not affect binding to the deacetylase activity or to HDAC1.
Light activity was not significantly associated with LTL.
Light and laser therapies are among the most effective treatment options for skin rejuvenation.
Light as impinging on the retina , especially the short wavelength form , affect mitochondrial chromophores and can result in neurone death.
Light-chain amyloidosis is a relatively rare multisystem disorder.
Light intensity physical activity and sedentary behavior are potential determinants , but their relations to these outcomes are poorly understood.
Light irradiances were normalized with respect to the natural sunlight reaching the retina.
Light is blocking the production of melatonin in the pineal gland , darkness is stimulating it.
Light microscope field co-ordinates enabled ReTm mapping and statistical testing relative to i ) sex , ii ) tissue sector and iii ) slicing plane.
Light PA is popular among older adults , but a paucity of objective longitudinal data has considered the relationship between light PA and cognitive ability.
Light scattering controls the periphery from about 1° onwards.
Light scattering from both IOL surfaces was measured using Scheimpflug photography.
Lights were off between @time@ h and 8 : 00 h.
Light therapy has developed for use in combination with other technologies or stand alone.
Lightweight body fixed sensors were placed on each wrist and lower back.
Like ABCA1 , ABCA7 exported choline phospholipids in the presence of apoA-I and apoE ; however , unlike ABCA1 , cholesterol efflux was marginal.
Like adverse oral health conditions , Alzheimer disease and related disorders are also very common among aging populations.
Like all acids , SA can produce somatosensory and visible irritation to the skin and as such may be unsuitable for subjects with sensitive skin.
Like controls , participants with MCI were able to successfully modify their plan online , improving their performance from task formulation to task execution.
Like CVL , HSVL estimates depend on definitions of the clinical population and assumptions about missing data.
Like dementia , late-life depressive disorders are common and are linked to increased disability , high healthcare utilisation , cognitive decline and premature mortality.
Like face perception , face recognition has a protracted maturational course.
Like health care systems in other developed countries , Japan's health care system faces significant challenges due to aging of the population and economic stagnation.
Like humans with AD , aging mice expressing human amyloid precursor protein ( hAPP ) showed increased levels of astrocytic A2A receptors.
Like in the general population , underweight is a risk factor for mortality in old nursing home residents.
Likelihood of treatment was associated with polypharmacy ( ≥5 drugs ) and with higher Cumulative Illness Rating Scale ( CIRS ) score.
Likelihood ratio tests and stratified analysis were used to investigate physical activity and body mass index as potential effect modifiers.
Like livers with activated mTORC1 , livers from aged mice have a defect in ketogenesis , which correlates with an increase in mTORC1 signalling.
Likely explanations given need to be further investigated.
Likely , myeloperoxidase ( MPO ) secreted by activated macrophages in atherosclerotic lesions is the promoter of such apoA-I oxidation.
Like many humans , non-human primates deposit copious misfolded Aβ protein in the brain as they age.
Like many mineralized tissues , bone can resist deformation and fracture from the nature of its hierarchical structure , which spans molecular to macroscopic length-scales.
Like many other neurodegenerative diseases , age is a major risk factor in the development of ALS / FTD.
Like memory T cell populations , innate immune cells may be increased in number but decreased in efficacy on a per-cell basis.
Like men , women committed suicide mainly by hanging themselves , and their suicide was frequently associated with degenerative illnesses and comorbidities.
Like other collagen-rich tissues , it can be affected by internal factors including aging and location.
Like other forms of focal dystonia , spasmodic dystonia does affect the somatosensation of nondystonic muscle systems.
Like other opioids , sufentanil creates a stable hemodynamic environment in cardiovascularly compromised pediatric patients.
Like p21 , p16 did not cause senescence in high cell density.
Like p21 , PD0332991 initiated senescence at any concentration that inhibited cell proliferation.
Like previous studies , we constructed microsimulation models.
Like the original FaB , the French Canadian version of the tool ( FaB-FC ) is valid and reliable for assessing fall-related behaviors.
Like the other small island states in the region , the Seychelles continue to be threatened by arbovirus outbreaks.
Likewise a cell in homeostasis contains many organelles , but none of these organelles work on their own.
Likewise , aging induced effects upon performance correlated only for monolinguals to decreased gray matter in the DLPFC.
Likewise , DDR inhibition could also restore MYOD's ability to activate the myogenic program in human senescent fibroblasts.
Likewise , disturbances in neuroendocrine functioning are emerging as potentially important contributors to HIV-associated neurocognitive alterations.
Likewise , DMF protected endothelial cells from TNF-α-induced apoptosis and the dysfunction characterized by decreased eNOS expression.
Likewise , each @number@ increase in baseline cognitive impairment was associated with a @number@ increase frailty at follow-up ( p < @number@ ) .
Likewise , elevation of MCP- @date@ be related to decreased muscle mass and increased content of adipose tissue in bladder of elderly OAB patients.
Likewise , excessive autophagy induction can cause autophagic stress and neurodegeneration.
Likewise heritability and segregation research have conflated lifespan with longevity.
Likewise , increasing FI-CGA values on admission were significantly associated with a longer length of hospital stay.
Likewise , individuals in the first three quartiles for CRP , TNF-α or IL-10 had similar values of CAC , mean and maximum IMT.
Likewise , it could be shown that the lifespan of yeast , nematodes and flies is prolonged by pharmacologically stimulated autophagy using exogenous administered spermidine.
Likewise , memory , aging , and AD modify 5-HT6 receptors and signaling cascades.
Likewise , most evidence from both human and animal studies supports a suppressive effect of estrogen on sclerostin levels.
Likewise , no difference of aL1 copy number in brain and blood were indicated between AD patients and the aged-matched control group without dementia.
Likewise , of @number@ participants with probable dementia , only @number@ ( @percent@ ) sought treatment from a health care provider.
Likewise , @percent@ of patients who had thyroplasty surgery reported a significant treatment effect compared to @percent@ for injection augmentation.
Likewise , polypharmacy , i.e. , multiple drug use , is common among older adults.
Likewise , positive statistically significant associations were found between state educational requirements and state training requirements and the five quality indicators.
Likewise , surgical interventions for affected hand joints have not proven as successful as joint replacement for the knee or hip.
Likewise , systematic comparative studies of the chemical constituents of medicinal Achyranthes plants resources with the same local name are also needed.
Likewise , tannin analyses have been undertaken in several studies , but explanations of the decline in wine astringency remain to be developed.
Likewise , the autofluorescence of phagocytosed photoreceptor outer segments increased by lysosomal alkalinization was restored @percent@ by a P2X7R antagonist.
Likewise , the category of impaired cognition increased the chances of caregiver burden @number@.34-fold.
Likewise , the CC genotype was significantly associated with higher obesity prevalence in all populations only in the high-saturated fat stratum.
Likewise , the diagnosis should be considered in women presenting with recurrent urinary tract infections.
Likewise , the frequency of central disc herniation increased significantly ( P < @number@ ) with age at all cervical levels.
Likewise , the histological score of synovial damage was also increased significantly.
Likewise , the lower-alpha desynchronization in large problems increased , whereas the theta synchronization in small problems decreased.
Likewise , the PM also displayed a constant morphology.
Likewise , therapy is more difficult because of potential side effects and drug interactions.
Likewise , the relaxing effect of adenosine on precontracted detrusor muscle was also significantly more pronounced in young compared with older detrusor.
Likewise the value of surgical hematoma evacuation remains uncertain.
Likewise , the ways in which older men's discussions on sex may be used as an avenue for \ "doing \ " masculinity remain underexplored.
Likewise , they are often associated with cardiovascular diseases.
Likewise , tumors in old mice were less susceptible to either PLD or RFA monotherapy.
Likewise , use of L / Z-containing supplements raised MPOD.
Likewise , with tinnitus patients , assessment for anxiety / depression should be considered.
Lilly proposed that the problem was not due to LY2886721 anti-BACE1 activity.
Lim3 encodes an RNA polymerase II transcription factor with a key role in neuron specification.
Limbal ET ( LET ) in four quadrants was manually measured from OCT images.
Limb BFR during exercise may need to be more cautiously prescribed to those with compromised cardiac conditions.
Limb kinematic data and upper extremity electromyographic ( EMG ) activity were acquired.
Limb venous compliance decreases with advancing age , even in healthy humans.
LIMITATION : All studies we screened were published online except for unpublished articles.
LIMITATION : A single quality measure was assessed.
LIMITATION : Doses of vitamins may be too low or the population may be too well-nourished to benefit from a multivitamin.
LIMITATION : Due to the small sample size no differentiation was made among the various CVD conditions.
Limitation : Functional status was self-reported.
Limitation : Heterogeneity of frailty assessment , limited generalizability of multicomponent frailty instruments , few validated frailty instruments , and potential publication bias.
Limitation in compatibility was discussed between the results by ICP-SF-MS and that by traditional graphite furnace atomic absorption spectrometry.
LIMITATION : Limited to single-center , cross-sectional , and medical patients only.
LIMITATION : Limited trial evidence targeting primary prevention in adults aged @number@ years or older.
LIMITATION : No direct markers of care quality or access.
LIMITATIONS : A clinical help-seeking sample , with low sociodemographic and geographic variability , may limit the generalizability of the findings.
LIMITATIONS : A limitation of this study is the small number of patients , yet the results show a significant improvement.
LIMITATIONS : A limited number of studies met our inclusion criteria.
LIMITATIONS : Analyses of BIA and frailty were cross-sectional ; BIA was not measured serially and incident frailty during follow-up was not assessed.
LIMITATIONS : Analysis of routine data.
Limitations and future research avenues are discussed.
Limitations and suggestions for future research , including the examining of the developmental pattern of gender differences across the lifespan , are discussed.
LIMITATIONS : A short follow-up period and serum testosterone measured on a single occasion.
LIMITATIONS : Automatic segmentations were not validated by histology.
LIMITATIONS : Broader application of these findings ( eg , across races and Fitzpatrick skin types ) will require further studies.
LIMITATIONS : Costs and outcomes were derived from a short-term randomized controlled trial and were protocol driven.
LIMITATIONS : Cross-sectional design ; only CES-D for evaluating mood ; participants not totally representative of general population.
LIMITATIONS : Cross-sectional study in a single-center is a limitation.
LIMITATIONS : Depression and dementia were not diagnosed according to standardized diagnostic criteria.
LIMITATIONS : Despite being blinded to the name of the app , @number@ control group participants ( @percent@ ) used MyFitnessPal.
LIMITATIONS : Diagnoses of advanced adenomas are based on records from a large number of endoscopists and pathology laboratories.
LIMITATIONS : Different definitions of self-medication were employed in the identified articles , which hindered the comparison between studies and meta-analysis.
LIMITATIONS : Different methodologies of measurement and different reporting methods of SB made synthesis difficult.
LIMITATIONS : Given the cross-sectional nature of the research , no firm conclusions can be made in terms of directions of causality.
LIMITATIONS : GMS-AGECAT is insufficiently equipped with diagnostic procedures to identify specific types of anxiety disorders.
LIMITATIONS : Heterogeneity in type and dosage of antidepressant medication.
Limitations include exclusion of men with serious co-existing conditions and limited sample sizes of men aged ≥75 years.
Limitations include lack of consensus for operationally defining waning as well as for the apparent ceiling.
Limitations include measurement error and nonresponse , with both biases likely favouring the null.
Limitations include the smaller sample sizes for non-European ancestries and the inability to classify approximately one-third of the variants.
LIMITATIONS : Inclusion of two measures in the COS may increase the feasibility of potential uptake , but poses challenges for data synthesis.
Limitations in physical performance were assessed via questionnaire and frailty status was defined according to the Fried criteria.
Limitations in technology-including limited computer availability , documentation complexity , and sluggish sign-in processes-also were identified as barriers to effective and timely communication between practitioners.
LIMITATIONS : It was not possible to collect information about time since diagnosis , which limited conclusions regarding BD chronicity and telomere length.
LIMITATIONS : Limitations include a relatively small sample of early-onset cases , and the fact that age-of-onset was ascertained by retrospective recall.
LIMITATIONS : Limitations include reliance on self-report clinical measures and variability in comorbidity and concurrent pharmacotherapy due to the naturalistic nature of the study.
LIMITATIONS : Limited sample size in the reversal cohort , unavailability of antibiotic use and urine albumin data.
LIMITATIONS : No causal relationships can be drawn due to the cross-sectional design of the study.
LIMITATIONS : Non-English articles were excluded ; therefore , the transferability of findings to other populations is unclear.
LIMITATIONS : Not all patients underwent kidney biopsy , especially those with very old age or ESRD at presentation.
LIMITATIONS : Novel devices yet to be invented may not fit into the designations proposed and may require additional categories.
Limitations of available scientific evidence on the topic are also discussed.
Limitations of imaging modalities , short duration of follow-up in longitudinal studies , and differences among cohorts examined may all contribute to conflicting results.
Limitations of the study and future directions are discussed.
Limitations of the study include the lack of information on chemotherapy in the SEER database and possible heterogeneity of cases.
Limitations : One limitation is the recruited patients , who have relatively high-functioning ability in the LF-MAL.
LIMITATIONS : Only head rotation movements on the horizontal plane were tested.
LIMITATIONS : Only one of the three studies was specific to older people and all studies involved patients in orthopaedic settings.
LIMITATIONS : Our findings are restricted to male former medical students , which may affect study generalizability.
LIMITATIONS : Our sample was small , did not include a placebo arm , and we examined only specific regions of interest.
LIMITATIONS : Owing to the use of questionnaires , the possibility of recall bias exists.
LIMITATIONS : Patients were treated with different antidepressant drugs , depending on individual parameters and disease courses.
LIMITATIONS , REASON FOR CAUTION : Age at menopause was self-reported and assessed retrospectively.
LIMITATIONS , REASON FOR CAUTION : The study population comprised women attending the FAC Clinic.
LIMITATIONS , REASONS FOR CAUTION : Occasionally , germ cells can be absent in some tubular sections.
LIMITATIONS , REASONS FOR CAUTION : Participants were relatively young.
LIMITATIONS , REASONS FOR CAUTION : The body of literature currently available limits these findings.
LIMITATIONS , REASONS FOR CAUTION : The sample size and the recruitment methods may limit the generalizability of these findings.
LIMITATIONS , REASONS FOR CAUTION : The study population is small and in the mid-to-late reproductive age group.
LIMITATIONS : Residual confounding was possible , although many confounding factors were considered.
LIMITATIONS : retrospective study of routinely collected data.
LIMITATIONS : rs13038305 explains only a small proportion of cystatin C variation.
LIMITATIONS : Single baseline measurement of Clcr and 3-year interval between follow-up visits may lead to nondifferential misclassification and attenuation of estimates.
LIMITATIONS : Single-center study.
LIMITATIONS : Single-center study , small sample size , and only Fitzpatrick skin types I and II enrolled were limitations.
LIMITATIONS : The causal direction could not be determined owing to the cross-sectional design and lack of detailed data on smoking addiction and smoking history.
LIMITATIONS : The causal direction could not be fully determined due to the cross-sectional nature of the data.
Limitations : The CCHS data are cross-sectional and self-reported , which prevents determining causality and carries a risk of response bias.
LIMITATIONS : The cross-sectional design limits the examination of causative relationships.
LIMITATIONS : The cross-sectional nature of this study does not allow for inferences of causation.
LIMITATIONS : The data presented are those that resulted from a single treatment session.
LIMITATIONS : The data represent performance of a healthy , young adult cohort.
LIMITATIONS : The generalizability and transferability of results to other settings , populations , or brands of infant formula should be made with caution.
LIMITATIONS : The limitations of the present study were inherent limitation in the LTA model and some small proportion of transitions.
LIMITATIONS : The main limitation was that subdividing the sample resulted in smaller samples for the subanalyses.
LIMITATIONS : The present study consists of small number of participants and body mass index ( BMI ) scores were not obtained.
LIMITATIONS : The principal methodological limitation was the retrospective observational nature.
LIMITATIONS : There are several limitations.
LIMITATIONS : There exists only @number@ RCTs and the number of participants is limited.
LIMITATIONS : The relatively small sample size and lack of functional experiments are the major limitations of this study.
LIMITATIONS : The response rate was @percent@.
LIMITATIONS : The response rate was @percent@ and this may have resulted in an underestimation of depression.
LIMITATIONS : There was limited statistical power , particularly for subgroup analyses.
LIMITATIONS : These were resource-intensive processes to develop and implement the program that need to be compared to less-intensive alternatives.
LIMITATIONS : The smallness of the sample from a single study site limits the generalizability of the findings.
LIMITATIONS : The small number of subjects may have led to reduced power to detect real differences.
LIMITATIONS : The study population may not reflect the general population.
LIMITATIONS : The study was conducted in a single geographic area and included only Mexican American Hispanic individuals.
LIMITATIONS : This is a small case series , and there was no direct control to compare the persistence of small-particle versus large-particle correction.
LIMITATIONS : This population was self-selecting as they chose to continue treatment for @number@ or more years to be eligible.
LIMITATIONS : Uncertainty in effectiveness estimates.
LIMITATIONS : Urinary albumin or longitudinal measures of eGFR were not available.
Limitations Walking performance was characterized by a single parameter ( time ) , whereas other spatiotemporal parameters have been related to dual-task performance.
LIMITATIONS : We lacked data for concentrations of parathyroid hormone , fibroblast growth factor @number@ or vitamin D metabolites.
Limitations were addressed according to the impairment ( s ) perceived to be causing them.
LIMITATIONS : We were unable to access clinical data or electrophysiological studies to correlate with MR image findings.
LIMITATION : The findings may not be generalizable to populations with a larger proportion of high-risk persons and were not validated in an independent cohort.
Limitation : The results of this trial are indeterminate and do not rule out potential clinically important effects of the intervention.
LIMITATION : The study design was cross-sectional and therefore precluded any causal inferences.
Limited available evidence indicates that several botanical agents and vitamins in topical or oral forms may have promising photoprotective effects.
Limited case management services were found.
Limited conclusions can be drawn for unpartnered older adults as their sexual behaviour was infrequent.
Limited consideration of mealtimes in policy and funding documents was identified as a primary barrier in further prioritizing mealtime management and advancing mealtime care.
Limited data are available for domestic-related activity ; therefore , the assessment of the activity levels of homemakers has been sparse.
Limited data are available on Canadians ' current advance planning activities.
Limited data are available to demonstrate the functional and economic impact of upper extremity fragility fractures.
Limited data have related dietary patterns with stroke risk in Chinese population.
Limited data on health care issues of older adults with SCD poses multiple challenges to patients , their families and health care providers.
Limited data provide evidence that effects of phytoestrogens on cognition may be modified by dosage , duration of consumption and cognitive test used.
Limited data suggests that older LGBT adults underutilize health and social services that are important in maintaining independence and quality of life.
Limited data suggest that some anti-inflammatory agents may have antidepressant properties.
Limited desensitization after repeated application and good overall tolerability were observed , although a modest long-term anti-wrinkle effect was shown by both products.
Limited diffusion of orbicularis oculi was detected with CNE.
Limited effects on strength and functional ability might be related to insufficient training intensity and lack of adherence.
Limited evidence suggests women exhibit a dampened response to contraction-induced muscle damage ( CIMD ) .
Limited information is available for rituximab and tocilizumab.
Limited information is available on normative FMD values in healthy children and adolescents.
Limited information is available on the molecular mechanisms regarding the negatively regulated expression of PAI-1 in the vascular system.
Limited information is available regarding compartment-specific changes in bone.
Limited information is available regarding the role of NKT cells in the HIV disease progression especially HIV-1 C infection.
Limited morphological changes were observed in mice lacking inducible NOS ( iNOS ) or neuronal NOS n ( NOS ) .
Limited opportunities for socialization were strongly expressed , particularly among older lesbians.
Limited overlap was observed in microglial genes regulated during aging between mice and humans , indicating that human and mouse microglia age differently.
Limited plantar flexor strength and hip extension range of motion ( ROM ) in older adults are believed to underlie common age-related differences in gait.
Limited research data suggested the effectiveness of treatments , especially for women.
Limited research exists on how these groups maintain family ties from afar including caring for aging parents.
Limited research explores the experience of individuals with dementia in acute care geriatric psychiatry units.
Limited research has been conducted on healthcare-associated infective endocarditis ( HAIE ) , although it is of increasing importance.
Limited research has studied the effects of neighbourhood age-friendliness on elderly health outcomes.
Limited resources should be prioritized for such individuals in terms of preventative , rehabilitative and palliative care.
Limited short-term positive effects ( 2-4 months ) of oestrogen treatment were found in women without ( as well as with ) dementia.
Limited studies exist regarding whether incorporating micronutrient supplements during tuberculosis ( TB ) treatment may improve cell-mediated immune response.
Limited studies have been conducted to compare different interaction style of intergenerational interaction.
Limited studies have investigated the effect of health care services on longevity.
Limited studies suggest that TDP-43 pathology is infrequent in neurologically normal elderly ( @percent@ or less ) .
Limited support of early-career clinician-educators is a major barrier to attaining this goal.
Limited therapies are available for other respiratory viruses.
Limiting exposure to nephrotoxic drugs is critical in decreasing the incidence of acute kidney injury in the elderly patient.
Limits , implications , and future research are discussed.
Limits of agreement for men were from @number@.95cm to @number@.09cm and for women from @number@.58cm to @number@.44cm.
Limits of normality of LV strain by Vsp 3D STE should not be used interchangeably with Vsp 2D STE or with Vin 3D STE software.
Limits of stability get worse with age , namely after the age of 40-50 years.
Limits of the variations of the crystal lattice parameters of the enamel apatites connected with the complicate processes of de- and remineralization have been determined.
LINE-1 and Alu methylation were not significantly associated with cancer prevalence at baseline ( all cancers combined ) .
LINE1 repeats , integrating into different chromosomal loci , affect the activity of genes and cause different genomic mutations.
LINE1 retrotransposons are members of a class of mobile genetic elements capable of retrotransposition in the genome via a process of reverse transcription.
Lineage or cell of origin of cancers is often unknown and thus is not a consideration in therapeutic approaches.
Linear ablation lesions are created within the mitral isthmus for the invasive treatment of left atrial arrhythmias.
Linear age increases were consistently evident in both PATS and ATUS , and replicated across the different indices of mixed emotions.
Linear and logistic regression analyses were used to evaluate renal and cardiovascular parameters.
Linear and logistic regression models were applied.
Linear and logistic regressions were used to model continuous NAB and dichotomized NAB respectively using single proteins as a predictor.
Linear and logistic regression were used to investigate to which extent comorbidities , aging and HIV infection were independently associated with HRQL and depression.
Linear and non-linear curve fitting of R2 ' vs. R2 in phantoms revealed increased slopes with increasing particle size.
Linear combinations of M-modes and their relationship to changes in the COP displacement in the anterior-posterior direction were then determined.
Linear correlation analysis between vBMD and age was performed.
Linear discriminant analysis ( LDA ) and support vector machine ( SVM ) were used as candidates for the classification technique.
Linear equations for each individual were derived from the activity counts and energy expenditure measured during the walking protocol.
Linear gait variability was assessed using the average standard deviation of trunk acceleration between strides ( VAR ) .
Linear measures of amplitude , frequency , and between-limb coupling ( coherence ) were performed.
Linear microcrack density and diffuse damage were measured in @number@ common donors with AGE and resorption measurements.
Linear mixed effects analyses with appropriate covariates were used to model MMSE decline over time.
Linear mixed effects modelling was used to determine the association of age and aortic stenosis on regional AD.
Linear mixed-effects models examined associations between sedentary behavior and outcomes adjusting for demographics and accelerometer physical activity.
Linear mixed-effects models revealed transfer effects on spatial episodic memory and reasoning that were still observed @number@ months after training.
Linear mixed-effects models showed that global cognition at baseline was associated with the rate of declining mobility.
Linear mixed-effects models were applied to test the relationships of clinical variables and cytokine concentrations to each cognitive domain.
Linear mixed effects models were used to analyze the effects of age on phosphorus metabolite concentrations , intracellular magnesium and pH estimates in brain tissue.
Linear mixed-effects models were used to investigate the associations of demographic and intellectual enrichment measures with global cognitive z score trajectories.
Linear mixed effects models with random intercepts were implemented to take into account repeated measurements.
Linear mixed-effects regression modeling of grip strength ( kg ) versus continuous miRNA ' Cq ' values and versus binary miRNA expression was performed.
Linear mixed model analyses were used to regress autotaxin against MRI , FDG-PET , and cognitive outcomes.
Linear mixed model analysis was used to measure the effect of age on RNFL thickness measurements over the @number@ years.
Linear mixed modeling produced a robust model although statistically underpowered.
Linear mixed-models analyses were performed with four measurement time points : baseline , 3-year , 6-year , and 12-year follow-up.
Linear mixed models and joint models , which accounted for competing risks from death , dropout , or kidney transplantation , showed nearly identical results.
Linear mixed-models were fitted for continuous outcome variables and GEE models with logit link function for binary outcome variables.
Linear mixed models were generated to examine associations between genetic factors and cognitive performance.
Linear mixed models were used to account for intra-person and site-level clustering.
Linear mixed models were used to assess the effect of age and premutation status on AMH levels and to determine a modeled AMH value.
Linear mixed models were used to determine differences in reaction time over time and per treatment.
Linear mixed models were used to evaluate the differences in rate of change across diagnosis and genetic groups.
Linear mixed models were used to examine the association of dietary scores to change in cognitive function.
Linear mixed models were used to model longitudinal cognitive change.
Linear mixed models which included a random study effect were calculated for both , the laboratory and the clinical studies.
Linear mixed regression models tested the effect of HIV on hearing after adjustment for age , sex , race , and noise exposure history.
Linear model for categorical data was used to test differences on tobacco consumption between three birth elderly cohorts.
Linear models also revealed an association between lower total cholesterol and accelerated decline in visual memory performance.
Linear models were used to test the relationship between gonadal status and determinants of physical performance.
Linear , multilevel , and logistic models compared individual resources at baseline as independent , cumulative , and binary predictors of outcomes @number@ years later.
Linear multiple regression was used in statistical analysis.
Linear multivariate regression analysis was performed to assess the association of social factors , health variables and grip strength.
Linear , quadratic , and cubic terms were included for BMI ( self-reported ) .
Linear regression analyses investigated the relationship between the built environment features and self-reported physical activity and walking.
Linear regression analyses showed significant declines in FDLs at both frequencies as age increased.
Linear regression analyses were performed and adjusted for sociodemographic , lifestyle and clinical factors.
Linear regression analyses were performed on the trait scores to produce pooled-sample age estimation equations.
Linear regression analyses were performed separately on data from adults and children.
Linear regression analyses were performed to assess the effects of age on the anatomical measures of each subfield.
Linear regression analyses were performed to examine the effects of various ocular and systemic factors on macular thickness.
Linear regression analyses were used to determine intervention effects on urinary sodium excretion.
Linear regression analyses were used to determine the predictors of each domain of quality of life.
Linear regression analyses were used to determine whether HOAs were associated with age or other factors.
Linear regression analyses with generalized estimating equations were used to examine changes in sleep duration around retirement.
Linear regression analyses with QoL and GDS-15 score as dependent variables were performed.
Linear regression analyses with the stepwise method were carried out with the SPSS @number@ package.
Linear regression analysis detected @number@ significant ( Bonferroni threshold p = 2.44×10 ( @number@ ) ) associations between @number@ analytes and @number@ SNPs.
Linear regression analysis determined the significance of relationships between age and width of the pelvis.
Linear regression analysis was performed to assess the effect of various factors on nutritional status.
Linear regression analysis was performed to determine the effect of age on nasal and temporal ciliary muscle morphologic characteristics.
Linear regression analysis was performed to identify significant independent related factors for GDS and PSQI scores.
Linear regression analysis was used to detect age-related differences in single CoP parameters and composite scores - adjusted for gender , height and weight.
Linear regression analysis was used to detect the contribution of social engagement and social support to SOC and its components.
Linear regression analysis was used to estimate the cross-sectional relationship among cortisol levels , brain volumes , and cognitive functioning , adjusting for covariates.
Linear regression analysis yielded a decline in BL thickness of @number@ μm per year.
Linear regression and ANCOVA were used to determine the effect of the premutation on outcome measures adjusting for age and education.
Linear regression and Cox proportional hazards analyses were performed.
Linear regression and mixed effects regression analyses were used to predict mean PV and longitudinal change in PV over time.
Linear regression and multivariate normal regression models were used.
Linear regression and proportional odds models were used to compare groups and covariables in respect to cIMT.
Linear regression and Student t test were used for statistical analysis.
Linear regression confirmed with bootstrapping indicated that thigh muscle size mediated @percent@ of the relationship between normal weight and mortality.
Linear regression , including race as a potentially confounding factor , was used to assess the association between age and mean eyelash characteristics.
Linear regression indicated a positive relationship between EMG and aging for the control group , whereas that relationship was negative for participants with CP.
Linear regression modeling was used to study the associations between cerebellar volumes and cognitive measures , independent of cerebral volumes.
Linear regression models , adjusted for potential confounders , were used to assess effects of particles and SNP-by-pollutant interaction.
Linear regression models of the minimum word duration necessary for correct identification and identification failure rates were developed.
Linear regression models tested the multivariate associations between distress and community participation , and whether this association differed for retired and working people.
Linear regression models were applied to assess the association between PARKIN mutation status and cognitive domain scores and UPDRS-III scores.
Linear regression models were constructed with adjustment for age and sex ; and additionally for vascular risk factors and MRI markers including intracranial volume.
Linear regression models were fit on autosomal variants with minor allele frequencies ( MAF ) ≥1%.
Linear regression models were performed to assess the influence of pickiness on body mass index and diet with adjustments for possible confounders.
Linear regression models were used to assess longitudinal associations between 25 ( OH ) D levels and cognitive function.
Linear regression models were used to assess the association of self-neglect severity and cognitive function.
Linear regression models were used to assess the relationship between frailty and well-being.
Linear regression models were used to examine prospective associations between midlife determinants and sedentary time ( < 100 counts per minute ) in old age.
Linear regression models were used to examine the association between both reports of relational aggression and subjective well-being.
Linear regression models were used to examine the relationship between PLMS as predictors and sleep architecture , arousal index , and sleep efficiency as outcomes.
Linear regression models were used to report the effect of sociodemographic and health variables including age , sex , education on cognitive function.
Linear regression models were used to study the effect of age on association between body fat percentage and maximal walking speed.
Linear regression models with age as independent variable fitted by gender are displayed in Fig. @number@
Linear regression of FFR phase coherence and FFR amplitude at frequencies at and slightly below @number@ Hz showed significant decreases as age increased.
Linear regression revealed a moderate correlation between age and CSID in connected speech.
Linear regression revealed significant age-related decline in associative learning , spatial and recognition memory , and the level of strategy use.
Linear regressions of age revealed a concomitant global age-related reduction in cortical thickness , surface area and volume.
Linear regressions were fitted to study associations between HV and visual tasks.
Linear regression tested associations between cumulative genetic risk and PD age at onset.
Linear regression tested the effects of sexual orientation on the value of CMPs.
Linear regression was implemented to investigate ΔE with time for groups @number@ @number@ and @number@
Linear regression was performed , controlling for age , sex , education , baseline score on cognitive test , diabetes , and hypertension.
Linear regression was performed to assess the adjusted association between HR , IL-6 , and cortisol levels.
Linear regression was run to explore the age - telomere length relationship in each maternal groups.
Linear regression was used to assess the association between calorie-adjusted sodium intake and cognitive test scores with adjustment for demographic , behavioral and health measures.
Linear regression was used to compare cognitive performance according to tertiles of dietary pattern.
Linear regression was used to determine changes in T1ρ with age.
Linear regression was used to develop the equation to predict peak VO ( @number@ ) , based on age.
Linear regression was used to examine associations between health factors and mean Sal-T.
Linear regression was used to examine associations between potential risk factors and rate of long-term cognitive decline over time.
Linear regression was used to identify the number of physician contacts.
Linear regression was used to quantify the relationship between financial strain and oxidative stress.
Linear regression was used to relate carotid artery disease burden to downstream hemodynamics in the circle of Willis.
Linear regression with bootstrapped standard errors was used to adjust for demographic and medical factors.
Linear relationship among muscular mass and strength and with clinical and biochemical parameters , including PhA at uni- and multivariate analysis were performed.
Linear relationships were observed between O2MAX and both MCAv and CVRCO2 ( r = 0.58-0.77 , P < 0.05 ) .
Linear slope contributed significant unique variance for diabetes and dyslipidemia even controlling for age @number@ BMI.
Linear trend was estimated using continuous 25 ( OH ) D concentrations.
Lin G , Reed-Maldonado AB , Wang B , et al.
Linkage analysis was carried out with DNA samples of the proband and her parents by using the Human SNP Array @number@
Linkage and genome-wide association studies on a cohort of related Old English Sheepdogs identified a region on CFA4 strongly associated with the disease phenotype.
Linkage disequilibrium score regression of @number@ cell types implicated the regulation of myeloid gene expression in AD risk.
Linkage is being established with medical registries and environmental data.
Linkage results revealed significant evidence ( log-odds score = @number@ ) for a quantitative trait locus for mortality-optimized HAI in women on chromosome 9p24-p23.
Linkage studies of exceptionally long-lived families now support a longevity locus on chromosome @number@ other putative longevity loci differ between studies.
Linkage studies point to the long arm of chromosome @number@ being a susceptibility region for Alzheimer's disease ( AD ) .
Linkage to the National Patient Register ascertained all autism cases ( N = 883 ) .
Linkage to the Registry of Births , Deaths and Marriages ( Victoria ) was used to calculate survival in months following discharge from inpatient rehabilitation.
LINKED ARTICLES : This article is part of a themed section on Cannabinoids @number@
LINKED ARTICLES : This article is part of a themed section on Fat and Vascular Responsiveness.
LINKED ARTICLES : This article is part of a themed section on Fat and Vascular Responsiveness.
LINKED ARTICLES : This article is part of a themed section on Opioids : New Pathways to Functional Selectivity.
Linked medical records were analyzed until end of study , death , or OHIP ineligibility.
Linked to physical autonomy and / or mental losses , it can be a gateway to regression , increasing or establishing dependency.
Linking household composition of older persons and material well-being is an important step toward understanding quality of life among elders in less developed settings.
Linking pain qualities with other associated pain characteristics serve to develop a multidimensional approach to geriatric pain assessment.
Links between particulate pollution-a well-recognized environmental risk factor-and exceptional aging have not been investigated.
Links between role model features and views on aging suggest that role models may be useful in promoting successful aging.
Links between the most promising gene candidate and AD pathogenesis were explored in silico as well as experimentally in cell-based models and in human brain.
Links of activities and disability also use MRM.
Linseed and / or CLA can be fed to improve the fatty acid profile in beef with minimal impact on consumer liking.
Lip and cheek strength measures were greater for men than women , but tongue strength did not differ between sex groups.
Lipid accumulation product ( LAP ) is an index used for evaluating lipid overaccumulation in adults.
Lipid concentration changes have been reported in different brain regions , but often partially or as a percent of the total concentration.
Lipid disorders act synergistically with other risk factors to increase prevalence of calcific AS.
Lipid droplets ( LDs ) are intracellular organelles that store neutral lipids within cells.
Lipid fractions ( triglycerides , low-density lipoprotein cholesterol , high-density lipoprotein cholesterol ) were studied as continuous variables.
Lipid levels were directly measured and selected percentiles of all lipid parameters were calculated.
Lipid-lowering drugs had a protective effect against WML ( @number@ @number@ @date@ ) .
Lipid-lowering drug use was closely correlated with the clinical profiles , including multimorbidity markers and polypharmacy.
Lipid-lowering treatment is common , e.g. one-third of 75-84-year-old Swedes are treated with statins.
Lipid-mediated signalling regulates a plethora of physiological processes , including crucial aspects of brain function.
Lipid metabolic disturbances are related to many diseases , such as obesity , diabetes , and certain cancers.
Lipid metabolism dysregulation may play a significant role in PD pathogenesis ; however , large plasma lipidomic studies in PD are lacking.
Lipid nanoparticles generally demonstrated a greater response compared to polymeric nanoparticles.
Lipid oxidation can result in degradation of the cell membrane , whereas the oxidation of proteins can result in a change of their properties.
Lipid oxidation products that accumulate in aged tissues may generate protein dysfunction.
Lipid peroxidation in aging human retina has been shown by biochemical means.
Lipid peroxidation products also cause oxidative modification of nucleic acids ( and proteins ) .
Lipid peroxidative byproducts ( i.e. acrolein ) accumulate in aging and may play a role.
Lipid profile , including TCh , LDL , HDL , and TG , was evaluated by spectrophotometric method.
Lipid profile was determined in TP and BF participants.
Lipid rafts and caveolae are examples of cholesterol enriched domains , which have attracted keen interest.
Lipids accumulation in THP-1 cells and expression of aP2 , CD36 and lipid accumulation in peritoneal macrophages were measured.
Lipids and proteins are most sensitive to oxidative stress structures.
Lipids are essential for the structural and functional integrity of membranes.
Lipids are the building blocks of cellular membranes and are synthesized at distinct parts of the cell.
Lipids , but not proteins , extracted from oxLDL were more cytotoxic than oxLDL.
Lipids draw increasing attention of cell biologists because of the wide variety of functions beyond their role as building blocks of cellular membranes.
Lipids , glucose , liver enzymes and haemoglobin A1c analyses were carried out in a commercial laboratory.
Lipids in the skin are the most diverse in the entire human body.
Lipids play an important role in activating the cell signaling leading to AV bone deposition.
Lipids that cannot be stored in the engorged adipocytes become ectopically deposited in organs such as the liver , muscle , and pancreas.
Lipid traits ( total , low-density and high-density lipoprotein cholesterol , and triglycerides ) are risk factors for cardiovascular disease.
Lipoate is the conjugate base of lipoic acid , and the most prevalent form of LA under physiological conditions.
Lipoatrophy may be genetically inherited or acquired as a result of panniculitis , HIV infections or aging.
Lipofuscin , a nondegradable oxidation product of lipids , proteins and metals , is found in senescent cells.
Lipofuscin fluorescence was imaged in the RPE from human donors of various ages and from assorted mouse models.
Lipofuscin includes cell debris with catabolites of lipoperoxic cascade and lipid antioxidants.
Lipofuscin is highly fluorescent material , formed in several tissues but best studied in the eye.
Lipofuscin pigment accumulation is among the most prominent markers of cellular aging in postmitotic cells.
Lipoic acid is a key co-factor for a number of proteins including pyruvate dehydrogenase and α-ketoglutarate dehydrogenase , key complexes for cellular energetics.
Lipoic acid ( LA ) is an antioxidant able to produce its effects in aqueous or lipophilic environments.
Lipoinfiltration for volume contouring is another major advance.
Lipophilic β-blockers are associated with an increased risk of depressive symptoms.
Lipopolysaccharide ( LPS ) -induced activation of Toll-like receptor @number@ ( TLR4 ) elicits the innate immune response and can trigger septic shock if excessive.
Lipopolysaccharide ( LPS ) -induced cytokine production of CD56 + and CD56- monocytes was determined by intracellular staining or cytokine secretion assays.
Liposomes transferring docosanoic acid ( DA ) , the completely saturated form of DHA , to the cell cultures served as controls.
Liposuction-assisted medial thighplasty is the next step in the series of medial thigh contouring refinements to improve complications and outcomes.
Liposuction evacuation volumes ranged from @number@ to @number@ ml per thigh.
Liposuction was performed superior and lateral to the nasolabial fold using an order-made one-hole @number@.5-mm cannula.
Lipotoxicity and adipokines have been focused as key issues for explaining MetS in HIV patients.
Lips and the perioral area are of outstanding importance in youthful appearance , attractiveness , and beauty.
Lip vermilion area to volume , and vermilion height to cutaneous lip height ratios decreased with age in both sexes.
Lip volumization is also briefly covered.
Liquid chromatography tandem mass spectrometry analysis showed that the HMW aggregates derived largely from crystallins also contained filensin , phakinin , and carbonyl reductase @number@
Liquid nanodelivery systems include nanoemulsions , nanoliposomes , and nanopolymersomes.
Liraglutide causes some adverse affects including nausea , vomiting , acute nasopharyngitis and acute pancreatitis.
Liraglutide is a glucagon-like peptide-1 analog and recently started to be using as an incretin-based treatment for diabetes mellitus.
L is also the dominant carotenoid in the brain.
L-isoAsp content was highly increased in RBC membrane proteins from psoriatic patients.
Listeners achieved high levels of performance for all but the shortest stimuli , indicating that they were able to access vowel cues throughout the syllable.
Listeners can selectively attend to a desired target by directing attention to known target source features , such as location or pitch.
Listeners included younger normal-hearing adults and groups of older adults with and without hearing loss.
Listeners included younger normal-hearing adults and two groups of older adults with and without high-frequency sensorineural hearing loss.
Listeners included young normal-hearing adults and older adults with and without hearing loss.
Listeners nearly always reported a digit from one of the three competing streams , showing that reverberation did not render the digits unintelligible.
Listening conditions were adjusted individually to equalize stimulus audibility as well as the overall level of performance across participants.
Listening effort involves the attention and cognitive resources required to understand speech.
Listening to the radio was positively correlated with lower depressive symptom burden for Latinas and better cognitive functioning in Caucasians.
Lists of these words were presented in isolation and in sentence contexts to younger and older normal-hearing listeners and to older hearing-impaired listeners.
Literacy activities and education years had a significant interaction effect.
Literature data on the age-associated changes in arterial stiffness , peripheral resistance and cardiac contractility were gathered and used as an input for the simulations.
Literature from individuals with specific brain lesions has helped to map out these smaller regions of cognitive abilities.
Literature from @number@ to @number@ was reviewed.
Literature is replete with studies showing that stem cell function declines with aging , especially in highly proliferative tissues / organs.
Literature is reviewed in above fields to support this view.
Literature on prevalence , incidence , and time trends for CVD and its risk factors in Arctic Inuit populations was reviewed.
Literature on responsibility of adult children for aging parents reflects lack of conceptual clarity.
Literature on spine surgery in this patient population is limited by small cohort size , the heterogeneous patient population , and variable treatment protocols.
Literature reports cases in the elderly only as incidental findings , making the diagnosis unlikely in older patients.
Literature review identified only two case reports and eight studies with an age range above @number@ years.
Literature review included the @number@ most important studies regarding linkage between allograft function and telomere erosion , including @number@ of our own reports.
Literature says that in this age group as 15-30% of people receiving assistance from family doctors have diagnosed depression.
Literatures on perceived age and developmental issues in middle and later life are joined in analyzing perceived age and its implications for well-being.
LITERATURE SURVEY : Specific terms were identified for the literature research in MEDLINE , Scopus , Bandolier , PEDro , and Web of Science.
Literature was retrieved from EMBASE , MEDLINE , PsycInfo , and CINAHL.
Literature was searched on trials comparing different DAPT durations.
Lithium and valproate have been tested in a single randomized controlled trial and there is data of more limited quality with other compounds.
Lithium disilicate ( IPS e.max press , Ivoclar Vivadent ) three-unit FDPs were fabricated and cemented using self-adhesive resin cement.
Lithium-induced NDI is due to resistance of the kidney to arginine vasopressin ( AVP ) , leading to polyuria , natriuresis and kaliuresis.
Lithium is an important medication in the treatment of mood disorders.
Lithium is a well-established anti-inflammatory agent used in the treatment of bipolar disorders.
Lithium modulates signals impacting on the cytoskeleton , a dynamic system contributing to neural plasticity at multiple levels.
Lithium still retains its critical position in the treatment of bipolar disorder by virtue of its ability to prevent suicidal tendencies.
Little attention has been paid to the energy source in medium , i.e. , glucose , which feeds the cell's power plants : mitochondria.
Little attention was given to psychosocial and behavioural aspects of pharmacotherapy.
Little care was given to non-pharmacological lines of treatment.
Little data is available on other lipid modifying medication in the elderly.
Little evidence has been established pertaining to the time course of recurrent CAA-related microbleeds or larger hemorrhages.
Little evidence was found for the opposite direction that functional limitations predict ensuing changes in memory.
Little has been reported about the transitions between the different frailty states.
Little has been reported on the bonding of fiber reinforced composite ( FRC ) to silicone elastomers.
Little has emerged in terms of tangible benefits for people with dementia to date other than a hugely increased awareness at societal and governmental levels.
Little , however , is known regarding the effects of cognitive decline on driving performance and the means to detect it.
Little information is available on the pattern and determinants of the longitudinal change in PWV with aging.
Little is currently known about the presence or role of MUC1 in human disc degeneration.
Little is currently known regarding the effects of cell density on AβPP processing and Aβ generation.
Little is known about age-related changes.
Little is known about Autism Spectrum Disorder ( ASD ) in persons over age @number@
Little is known about concurrent relationships among chronic pain , sleep , and inflammation.
Little is known about determinants of survival in FTLD.
Little is known about diabetes care of elderly people with frailty , disabilities , or multiple comorbidities.
Little is known about diabetes management among low-income older Americans.
Little is known about factors other than age and sex potentially affecting brain iron concentration.
Little is known about hospices ' provision of such social supports and services.
Little is known about how age , metabolic syndrome , and hunger state interact to influence how the brain processes information about taste.
Little is known about how and where YLHIV receive their care.
Little is known about how and why coping changes over time , nor about stability of coping strategies in persons with osteoarthritis.
Little is known about how immobilization of the right lower limb might affect driving.
Little is known about how lesbians and gay men perceive the turning points that define their life trajectories.
Little is known about how normal cognitive changes in aging affect driving in the wider population of adults who drive regularly.
Little is known about how persons with dementia and their care partners respond to mealtime changes that occur throughout the dementia journey.
Little is known about how these perspectives relate to the individual characteristics of either affected party.
Little is known about how this trajectory compares with natural aging among peers of the same age without cancer.
Little is known about how well APNs were educated regarding UI , especially in older adult women.
Little is known about learning or adaptation with practice.
Little is known about location-specific effects of lesions on functional connectivity.
Little is known about long-term consequences of flight and expulsion during childhood.
Little is known about men's experiences in care work , and the dilemmas and opportunities they face because of their gender.
Little is known about patterns of physical activity or sedentary behavior in this population.
Little is known about postmenopausal health in cut women.
Little is known about potential links between bone and valvular calcification.
Little is known about potential treatments of these cognitive deficits.
Little is known about public attitudes towards age-stoppage policy.
Little is known about the association of magnesium intake and atherosclerotic calcification in humans.
Little is known about the association of serum potassium with atrial fibrillation.
Little is known about the cellular pathogenesis of FRDA in cardiomyocytes.
Little is known about the economic socialization of children and adolescents and the role of parents in this process.
Little is known about the effectiveness of interventions aimed at improving their dietary intake and nutritional status , nor about the determinants of successful implementation.
Little is known about the effectiveness of self-determination theory ( SDT ) , a representative motivational theory , on exercise domain in older adults.
Little is known about the effect of immunosuppressive therapy on the immune system of older patients.
Little is known about the effect of using the Screening Tool of Older People's potentially inappropriate Prescriptions ( STOPP ) in this context.
Little is known about the effects of age on short-term temporal dynamics of functional connectivity.
Little is known about the effects of risk factors on attention-deficit / hyperactivity disorder ( ADHD ) symptom over time.
Little is known about the experiences of older adults with SMI with weight management.
Little is known about the genome of the Okinawans , a potential population isolate , recognized for longevity.
Little is known about the impact of frontotemporal dementia ( FTD ) on sleep.
Little is known about the impact of healthcare exposure on the clinical features and molecular typing of methicillin-susceptible Staphylococcus aureus ( MSSA ) bacteremia.
Little is known about the impact of HIV and aging on cognitive functioning.
Little is known about the implication of the brain's two main fuels , glucose and ketones ( acetoacetate ) , associated with thesebenefits.
Little is known about the initiation of new sexual relationships in later life.
Little is known about their health care costs.
Little is known about the long-term effects of memory training in later life on strategy use.
Little is known about the molecular mechanisms driving their extended longevity particularly at the levels of gene expression and post-transcriptional regulation.
Little is known about the molecular mechanisms whereby treatments working at the epidermal level might alter the dermis.
Little is known about the neural processes associated with the representation of everyday sounds and how these may be affected by aging.
Little is known about the onset of driving self-restrictions or how widespread self-restrictions are among drivers of all ages.
Little is known about the psychosocial factors that might impact the functioning ability of heterosexual men living with HIV.
Little is known about the reaction of the posterior vaginal wall influenced by steroid receptor expression.
Little is known about the role of chromatin accessibility in DNA repair.
Little is known about the role of early life factors on body mass index ( BMI ) gain over the life course.
Little is known about the role of gender in the relationship between social support and health in older adults.
Little is known about the role of genetic influences on hearing when evaluated longitudinally.
Little is known about the variation of testosterone ( T ) levels caused by fluoride exposure.
Little is known about this intriguing cell type , as there are only a few case reports describing rod-shaped microglia in the neuropathological literature.
Little is known about this subset.
Little is known about what social capital inequalities in health represent , and which social factors contribute to such inequalities.
Little is known about whether ACP outside of a trial accomplishes this.
Little is known about whether this impairment arises early or late in the time course between healthy aging and AD.
Little is known about who is mostly likely to show associations between cognitive complaints and preclinical Alzheimer pathology.
Little is known as to how self-rated health predicts death in non-Western settings.
Little is known concerning the behavioral outcome of these patients after discharge.
Little is known for pacing profiles in age groups cross-country skiers.
Little is known how emotional salience of task-irrelevant stimuli may modulate cognitive control of WM performance and neurofunctional activation in MCI and AD individuals.
Little is known , however , about age-related changes in this ability across the life span when there is no opportunity to anticipate task goals.
Little is known , however , about how participation in adapted sports affects the quality of life of people with mobility limitations.
Little is known , however , about the additional burden that obesity may place on the iron status and immune response in the elderly.
Little is known , however , about their diagnostic value within the normative range.
Little is known , however , about their relation with personality development across adulthood.
Little is known , however , about their time-ordered interplay at various phases of adult life.
Little is known , however , about the molecular mechanisms that modulate the aggregation process in the cellular environment.
Little is known regarding age-specific issues that may impact the careers of emergency physicians in the latter stages of their professional lives.
Little is known regarding alterations of decorin in response to UV irradiation.
Little is known regarding how well psychosocial resources that promote well-being continue to correlate with affect into very late life.
Little is known regarding the processes governing typical development of these attention networks in the brain.
Little model of the inverted egg shape is also proposed.
Little potential for immunogenic reactions was identified.
Little research addresses midlife estrogen use after surgical menopause ; limited clinical trial data imply short-term benefit of prompt initiation at the time of oophorectomy.
Little research has addressed the effect of specific health conditions on sexual inactivity in this growing population.
Little research has addressed the heterogeneity and mortality risk in body mass index ( BMI ) trajectories among older populations.
Little research has been conducted , however , on the effectiveness of exercises for facial rejuvenation.
Little research has been published on the management of adverse drug events involving insulin in the outpatient setting.
Little research has examined whether such relationships persist longitudinally.
Little research has studied which of the two precedes the other following the death of a loved one.
Little was known about DPC-specific repair mechanisms until the recent identification of a DPC-processing protease in yeast.
Little work has directly assessed the role of self-regulation in risk of incident CHD.
Live-birth showed a strong negative correlation with female age but no correlation with male age.
Live cell fluorescence imaging revolutionized the field of cell biology and has become an indispensable tool in current biological studies.
Live disenrollment may be driven by factors other than patient preference and may create discontinuities in care , disrupting ongoing patient-provider relationships.
Liver biopsy samples from patients with NAFLD , with or without gallstones , were analyzed by quantitative reverse-transcription polymerase chain reaction.
Liver biopsy was performed in @number@ patients and all showed typical steatohepatitis.
Liver cancer is the fifth most common cancer and the third most common cause of cancer related death in the world.
Liver deaths will increase @percent@ to an estimated @number@ deaths in @number@
Liver failure ( LF ) continues to be a serious problem due to different underlying disorders.
Liver fibrosis was measured using the fibrosis @number@ index ( FIB-4 ) , which is calculated using age , aminotransferases , and platelets.
Liver gluconeogenesis is essential to provide energy to glycolytic tissues during fasting periods.
Liver histology showed age-dependent increase of steatosis and decrease of glycogen storage in both groups and none of the animals developed neoplastic lesions.
Liver injuries can be significant in vehicle crashes.
Liver injuries were more commonly associated with AIS 2 + thoracic injuries in adults than in children.
Liver injury patterns were also assessed in crash occupants.
Liver kinase B1 ( LKB1 ) is one of the upstream activators of AMPK.
Liver microarray analysis showed that high mIndy expression was associated with pathways involved in hepatic lipid metabolism and immunological processes.
Liver neoplasms included hepatocellular adenoma and hepatocellular carcinoma in males and females and hepatoblastoma in males.
Livers and biliary tissues were analyzed by histology , quantitative reverse-transcription polymerase chain reaction , immunohistochemistry , and immunoblots.
Livers from patients with NAFLD and gallstones express higher levels of HIF1A than livers from patients with NAFLD without gallstones.
Liver specimens from @number@ patients who died after liver failure were examined for the presence and distribution of CD68-positive KCs and CD83-positive DCs by immunohistochemistry.
Liver X receptors ( LXRs ) are important sensors and regulators for cholesterol , fatty acid , and glucose.
Liver X receptors ( LXRs ) play a critical role in regulating lipid synthesis and transport in numerous tissues.
Live worms recovered at @number@ weeks PI had a mean body area of about @number@ mm2.
Living alone increased the odds of having low SWB in women , but not in men.
Living arrangements , telephone contacts , providing social support , and receiving instrumental support were not significant.
Living bodies incorporate molecules involved in biological functions with all their potencies , not only those implicated in the respective functions.
Living cells maintain a balance between oxidation and reduction , and perturbations of this redox balance are thought to contribute to various diseases.
Living donors must be fully cognizant of the potential risk both in patient and graft survival prior to making such a life-changing decision to donate.
Living in a personal home or residential setting-aging in place-by contrast , costs an average of $ 23 , 000 per person per year.
Living in a suburban area ( HR = @number@ @percent@ CI : @number@.410-0.921 ) was associated with lower CVD mortality.
Living , not just existing , with a dementing illness involves encouraging the person to continue to be involved in meaningful activities.
Living systems are open , out-of-equilibrium thermodynamic entities , that maintain order by locally reducing their entropy.
Living with advanced dementia could be prevented if a person who cannot feed himself or herself would not be fed by others.
Living with children may indicate a higher level of support , which substitutes some of physician services.
Living with death is part of the daily routine of health professionals resulting in emotional overload.
Living with fewer people and having fewer children were only correlated with any anxiety symptoms and lower income was only correlated with anxiety disorders.
Liz and her co-twin , Ann Hunt , are listed in the @number@ Guinness Book of Records as the longest separated twins in the world.
LJM is frequently observed in young subjects with insulin-dependent diabetes mellitus ( IDDM ) .
LLD group had thinning in the left parahippocampal , fusiform , and inferior-parietal cortex compared with controls.
LLD is associated with cortical thinning , which is associated with age at depression onset , gender , and level of cognitive functioning.
LLE potentially prompted discontinuation ; however , some individuals continued to receive preventive medicines until they died.
LLFS spouses are also relatively healthy.
LLLT did not potentiate RF treatment.
LLTCOPs report the changing LTC environment and additional state mandates as factors influencing resource adequacy.
LM and FM of the total body ( TB ) , arms , legs , and trunk were assessed by dual-energy X-ray absorptiometry.
LM and LMI values continued to increase for boys up to age @number@ compared to girls who plateaued after age @number@
LMIC-born immigrants demonstrated higher levels of frailty in Northern / Western Europe , but not Southern / Eastern Europe.
LMI was calculated as the LM ( kg ) divided by the height in meters squared.
LMNA mutations can lead to laminopathies such as lipodystrophies , premature aging syndromes ( progeria ) and muscular dystrophies.
LMSChartmakerPro was used to create smoothed percentile curves corresponding to the 5th , 25th , 50th , 75th , and 95th percentiles.
LM was positively correlated with BMD at almost site ( all P < @number@ ) in groups , while FM had no association.
LMX1A is a transcription factor involved in the development of dopamine ( DA ) -producing neurons in midbrain.
LNCaP 104-R1 and 104-R2 mimics the AR-positive hormone-refractory relapsed tumors in patients receiving androgen ablation therapy.
LNCaP is a commonly used cell line established from a human lymph node metastatic lesion of prostatic adenocarcinoma.
LncRNAs , therefore , have important roles in healthy and diseased hearts , and might be targets for therapeutic intervention.
LN metastases are the most important prognostic factor in patients that undergo curative resection.
L-NMMA decreased baseline blood flow similarly , and the addition of milrinone increased baseline blood flow similarly in both groups.
L-NMMA during hypoxic exercise only blunted the compensatory vasodilator response in the young group ( P < 0.05 ) .
( LN ) or papaya ( Carica papaya L. )
Loaded skin showed marked changes in morphology and NLRP3 inflammasome protein expression.
Loading did not alter NLRP3 inflammasome proteins expression in aged skin , whereas it significantly increased their levels in young skin.
Loading reduced walking speed , with the shopping cart being the slowest , followed by the stroller and then the shopping bags.
Loading regulates genes involved in similar signalling cascades in both age groups , but these responses are more sustained in the young than aged.
Loading stimulates rapid and sustained transcriptional responses in both age groups.
Loading that can be applied to the bone is limited by bone structure.
Load levels and presentation times were varied within subjects.
Lobar atrophy present in most of the younger patients was prominent in only @percent@ of the elderly subjects.
Lobbying by special interests groups undermines reform and the public interest.
Lobectomy and sub-lobar resection are two main surgical approach for the treatment for this kind of patients.
Lobectomy , sublobectomy were performed for @number@ cases ( @percent@ ) , @number@ cases ( @percent@ ) , respectively.
Local AD was lower at locations of calcified and mixed thoracic plaque when compared to non-calcified thoracic atherosclerosis ( p < 0.04 ) .
Local and systemic protective mechanisms of the retina including antioxidant enzymes and macular pigments are reviewed.
Local anesthetics and NK1R antagonists are candidate drugs that may possess the capability to prevent venous thrombotic disorders in perioperative settings.
Local anti-inflammatory therapy of chronic periodontitis does not restore normal immunity status.
Local atrophy also accounted for age-related overactivation in left lateral parietal cortex.
Local BH4 perfusion augmented reflex vasoconstriction at Tsk ≤ @number@.5°C with placebo treatment only ( P < @number@ ) .
Local control per lesion and dosimetric prognostic factors for local control were assessed by univariate and multivariate Cox proportional hazards regression analyses.
Local control rates at @number@ @number@ and @number@ months were @percent@ , @percent@ , and @percent@ , respectively.
Local culture and the island lifestyle may provide a positive atmosphere for women going through menopause.
Local dry heat loss responses and cardiovascular strain were attenuated during the High condition in YOUNG compared to OLDER ( p < @number@ ) .
Local ethical protocol number : NL16222.094.07.
Local host immunity is essential to control colonising pathogens by preventing overgrowth , spread , and invasion.
Local infiltration , with or without general anesthesia , is commonly used.
Local intra-pocket drug delivery devices can provide an effective concentration of the antimicrobial agent at the site of action with avoidance of undesirable side effects.
Localized elements of stories included local headlines and local data.
Localized protein synthesis is a mechanism by which morphologically polarized cells react in a spatially confined and temporally acute manner to changes in their environment.
Localized scleroderma is a rare inflammatory dermatosis , manifested by atrophic skin and subcutaneous tissue alterations.
Local kyphotic angle was not correlated with delayed neurologic deficit.
Locally administered BH4 increases vasoconstriction through adrenergic mechanisms in aged human skin.
Locally advanced disease may refer to over-staged well-curable tumors as well as to advanced and probably incurable cancers.
Locally obtained plant foods can provide vitamin A and prevent deficiency of vitamin A , a remaining worldwide concern.
Locally , these decreases mostly occurred in the middle part of the lordosis and less towards the lumbo-sacral and thoraco-lumbar transitions.
Local muscle activation increased peak force by @percent@ , contact area by @percent@ , and peripheral hip force by @percent@ compared to relaxed trials.
Local populations formerly gardened the forest by creating scattered openings , which were sufficiently large for the establishment of light-demanding trees.
Local proinflammatory signals are coupled between the heart and arteries due to common mechanical and humoral messengers within a closed circulating system.
Local residents indicated that they established good relationships with village doctors.
Local safety was assessed by reported adverse events.
LOCAL SETTING : Ghana has a well-structured health system that can adapt to meet the health care needs of older people.
Local task-switching costs , on the other hand , showed a multiplicative complexity effect but no specific attention-related age deficits.
Local tolerability was assessed based on subject diary during the first @number@ weeks after injection.
Local wave speed is directly related to the arterial wall properties [ @number@ ] .
Location data were used to evaluate the number of daily excursions away from home as well as daily time spent away from home.
Location of adipose tissue deposit in abdominal region plays an important role in occurrence of hyperlipidemia , diabetes , hypertension and atherosclerosis.
Location-specific age-related changes of intra-orbital structures should be considered in the qMRI assessment of the orbital pathology.
Loci screened included @number@ regions known to drive clonal hematopoiesis when mutated and @number@ novel candidate loci.
Locomotive syndrome is defined as a condition of reduced mobility due to impairment of the locomotive organs.
Locomotive syndrome was defined as a score of @number@ or more on the 25-question Geriatric Locomotive Function Scale.
Locoregional recurrence was found in @number@ patients ( @percent@ ) , and hematogenous metastasis in @number@ patients ( @percent@ ) .
Locus coeruleus degeneration and reduced central noradrenaline content is an early feature of Alzheimer's disease.
Locus of control ( LOC ) measures the extent to which individuals perceive control over their lives.
LOD presented intermediate frequency of CD14 + monocytes expressing IL-1β between controls and AD patients.
LO-FTD ( @percent@ ) was more common than previously thought and the proportions of EO and LO groups differed across FTD subtypes.
Logarithmically transformed , the equation conforms to a straight line , of which the slope has been interpreted as the rate of senescence.
Log-binomial regression explored associations between demographic characteristics , antiretroviral therapy ( ART ) status and sensitivity of self-report.
Log binomial regressions were stratified by gender.
Log binominal regression models were used to calculate the relative risks of the dispensing of medications for various co-morbidities , taking into account potential confounders.
Loge FeNO values were used as dependent variables to test associations of demographic and health related-covariates.
Log-IL-6 levels were not associated with falls.
Logistic and Cox regression were used to examine the association between baseline SRH and treatment toxicity / time to death.
Logistic and linear regression analyses were used to adjust for potential confounders and explore potential mediators.
Logistic and linear regression models were used to assess these longitudinal associations.
Logistic , linear , and censored regression models were used to assess the associations between LTPA / OPA earlier in life and subsequent physical functioning.
Logistic models demonstrated similar findings.
Logistic models were used to analyze the determinants of anticoagulant prescription among age groups.
Logistic multiple regression analysis revealed that age , waist / hip ratio , FSH , SHBG and AR% are potential risk factors for DM.
Logistic multivariate analysis also revealed that high cfPWV , low PPA , high HR , and low ADLs were all determinants of MMSE decline.
Logistic regression analyses examined the odds of TBI as a function of sex , race , poverty status , age quintile and their interactions.
Logistic regression analyses indicated that higher pain and depressive symptoms were consistently associated with an increased likelihood of being classified as a chronic poor sleeper.
Logistic regression analyses indicated that individuals with high levels of either IL-6 or TNF-α had significantly higher odds for short LTL.
Logistic regression analyses revealed a significant moderating effect of exercise.
Logistic regression analyses revealed that volunteering was less observed among Hispanics ( OR = @number@ @percent@ CI @number@ @date@ ) .
Logistic regression analyses were adjusted for age , body mass index ( MMAS only ) , and use of PDE5i.
Logistic regression analyses were adjusted for age , sex , race , site , BMI , smoking , blood pressure , and physical activity.
Logistic regression analyses were applied to identify independent predictors within test measures for the differentiation of FTLD from AD.
Logistic regression analyses were conducted separately for men and women to evaluate the likelihood of being sexually active for each health condition.
Logistic regression analyses were performed.
Logistic regression analyses were performed.
Logistic regression analyses were performed to determine associations between sex-specific s.d. increments in PUFAs with risk of incident mobility disability and gait speed decline.
Logistic regression analyses were performed to identify fall predictors.
Logistic regression analyses were used to derive the results.
Logistic regression analyses were used to investigate associations with absence of OA.
Logistic regression analysis and receiver operating characteristic curves were used to examine the association of each CSF protein with CHC.
Logistic regression analysis did not reveal any male age-related influences on sperm parameters like concentration , motility or morphology.
Logistic regression-analysis identified independent predictors of unadjusted mortality and MACE.
Logistic regression analysis is used to analyze the data.
Logistic regression analysis of baseline and changes in physical activity with cognitive decline was performed.
Logistic regression analysis revealed a significant relation of ED with aging and LUTS ( P < @number@ ) .
Logistic regression analysis revealed that adjustment for smoking does not systematically alter the association between FOXO3A variation and longevity in neither population.
Logistic regression analysis showed that high Klotho gene expression was independently associated with lower risk for CAD.
Logistic regression analysis was carried out to reveal predicting variables for DLSS.
Logistic regression analysis was performed.
Logistic regression analysis was performed and the χ2 test for relevant calculations.
Logistic regression analysis was performed to identify factors associated with moderate-to-severe disability at hospital discharge in teaching and nonteaching hospitals.
Logistic regression analysis was performed to identify individual factors associated with the process of application for LTCI.
Logistic regression analysis was used to analyze the predictors of PA.
Logistic regression analysis was used to assess the impact of socio-demographic , health , and diet-related characteristics on depression.
Logistic regression analysis was used to calculate adjusted odds ratios ( aOR ) and 95%CI for the association with complicated EE.
Logistic regression analysis was used to determine if ALM added to age and sex improved the predictive discrimination of five-year and ten-year mortality.
Logistic regression analysis was used to determine risk factors for psychological distress among older men and women.
Logistic regression analysis was used to determine the predictors of severe symptoms.
Logistic regression analysis was used to estimate the association between the study outcomes and the different definitions of MUI.
Logistic regression analysis was used to examine 2-year mortality in both populations.
Logistic regression analysis was used to examine the association between therapeutic self-care ability and the occurrence of adverse events in home care.
Logistic regression analysis was used to identify factors associated with hearing aid and ALD usage.
Logistic regression analysis was used to identify the factors independently associated with sarcopenia.
Logistic regression analysis was used to seek baseline parameters associated with the natural outcomes of mild SCH.
Logistic regression and bootstrap analysis were used to assess the independent association between CAC and BMD.
Logistic regression and classification and regression tree analysis were performed to identify determinants of long QT syndrome.
Logistic regression and correlation analyses were performed.
Logistic regression and Cox proportional-hazards models were used to estimate the association of SES with CIND.
Logistic regression and multivariate linear regression models were performed.
Logistic regression and two-part models were used to analyze the association between frailty and the use of healthcare resources.
Logistic regression calculated odds ratios and @percent@ confidence intervals for development of low relative ASM , adjusted for covariates.
Logistic regression derived a significant model with @percent@ overall predictive value.
Logistic regression examined the odds of having cognitive impairment by sodium intake.
Logistic regression identified higher age as the strongest factor associated with trapeziometacarpal arthrosis , but sex was also a factor.
Logistic regression identified predictors of low patient engagement.
Logistic regression is utilized to analyze the association.
Logistic regression methods showed that older adults remained an independent predictor of hospital admission ( OR @number@ @percent@ CI @number@ @date@ ) .
Logistic regression modeled prevalent diabetes.
Logistic regression modeling revealed functional disability and cognitive function to be significant independent predictors of the outcome \ "mortality or dependency. \ "
Logistic regression modelling , with bootstrapping and sensitivity analyses , was used to estimate AR at death for dementia for specific pathologies and other factors.
Logistic regression models adjusting for sling type and clinical site were used to predict odds of overall treatment failure after univariable analysis.
Logistic regression models calculated odds ratios ( ORs ) of gait slowing with dementia or mild cognitive impairment with and without adjustment for GMV.
Logistic regression models determined predictors of NHP for total sample and for two different age groups.
Logistic regression models estimated the relationship between CML and prevalent frailty.
Logistic regression models examined odds of weight gain and functional decline by volume and intensity of physical activity.
Logistic regression models examined village and resident characteristics associated with PA.
Logistic regression models highlighted both MoCA test and motor RTs as the best predictors differentiating patients from healthy participants.
Logistic regression models of increasing complexity identified factors associated with FOF.
Logistic regression models were adjusted for age , sex , and % European ancestry.
Logistic regression models were adjusted for demographics.
Logistic regression models were applied to evaluate the effect of the ACCI score on the risk of prolonged POI.
Logistic regression models were applied to investigate gender-specific associations between potential risk factors and falls.
Logistic regression models were applied using the six-item De Jong Gierveld Loneliness Scale as dependent variable.
Logistic-regression models were calculated , sex-stratified , and controlled for age and living status.
Logistic regression models were constructed to test the association between B12 and incident albuminuria and RKF.
Logistic regression models were created to assess the association of neighborhood quartiles to outcomes , adjusting for key covariates.
Logistic regression models were estimated to assess the independent effect of residence on likelihood of psychotropic medication use.
Logistic regression models were fitted to estimate the risk of a specific behaviour associated with APOA2 genotype.
Logistic regression models were used to adjust odds of mortality and readmission to ICU for baseline case mix and illness severity.
Logistic regression models were used to analyze risk factors associated with sarcopenia.
Logistic regression models were used to analyze the survey data.
Logistic regression models were used to assess associations between age and clinically meaningful health related quality of life decreases ( worsening ) .
Logistic regression models were used to evaluate demographic characteristics associated with 25 ( OH ) D deficiency.
Logistic regression models were used to predict the usage of community-based services.
Logistic regression models with severe hypoglycemia as the dependent variable were used to test associations with antidiabetic agents.
Logistic regression model was used in the analyses.
Logistic regression model was used to identify possible associations with tobacco smoking status.
Logistic regression of self-reported discrimination and negative binominal regression of depressive symptoms were conducted.
Logistic regression predicted achieving recommended ≥150 min per week of moderate-vigorous PA ( MVPA ) versus not ( ≤149 min MVPA ) .
Logistic regression procedures estimated associations between variables.
Logistic regression procedures were used to estimate odds ratios ( ORs ) and @percent@ confidence intervals ( CIs ) .
Logistic regression reveals that social worker and physician intervention , not patient-specific variables , are the primary predictors of AMD incidence.
Logistic regressions also showed that highest degree earned is significantly ( p < @number@ ) predictive of longevity.
Logistic regressions computed the association between high CRP levels at baseline with elevated depressive symptoms at follow-up , and vice versa.
Logistic regression showed that older age , cardiovascular disease and hypertension were associated with GFR < 60 mL / min / 1.73m2.
Logistic regression showed those with systolic BP < 130 mm HG had an unadjusted odds ratio of @number@ ( @number@ @date@ ) for incident depression.
Logistic regressions revealed that age , early age at menopause , history of fractures , dysthyroidism and smoking were associated with high and moderate risk.
Logistic regressions were performed using SAS survey procedures to account for the complex survey design.
Logistic regressions were used to analyse the aggregate data to estimate the association between the @number@ smoke-free legislation and SHS exposures in homes and workplaces.
Logistic regressions were used to predict smoking from antagonism , discrimination , and their interaction.
Logistic regression tests failed to find any relationship between microbleeds and the variables.
Logistic regression using dichotomized outcome scales was applied to determine predictors of poor outcome.
Logistic regression was adopted for evaluating the association of HR exceeding the mean value with Il-6 and serum cortisol.
Logistic regression was also used to examine the relationship between functional status , comorbidity and SRH at baseline.
Logistic regression was applied.
Logistic regression was conducted to examine the relationship between alcohol consumption and cognitive impairment among Korean older adults.
Logistic regression was performed to quantify the association between socio-demographic and clinical factors and outcome.
Logistic regression was used to analyse the relationship of potential confounders with fall risk.
Logistic regression was used to assess similarity between the measures in predicting prevalent conditions.
Logistic regression was used to assess the association between sex steroids and incident MetS.
Logistic regression was used to assess the association between sexual activity and function and disease status , adjusting for age.
Logistic regression was used to assess the most sensitive gait , balance , and PA variables for identifying prefrail participants ( vs. nonfrail ) .
Logistic regression was used to determine the association of age with the occurrence of ≥1 PDDI.
Logistic regression was used to determine the effect of age , gender and education on cognitive outcome.
Logistic regression was used to determine whether the variables were associated with diabetes after adjustment for confounders.
Logistic regression was used to estimate odds ratios and @number@ % confidence intervals of CHD according to fish or fish-liver oil exposure.
Logistic regression was used to estimate the odds of cancer incidence with respect to frailty status in multiple models with progressive adjustment for covariates.
Logistic regression was used to estimate the odds ratio ( OR ) and @number@ % confidence intervals of frailty associated with ADMA.
Logistic regression was used to estimate the odds-ratio ( OR ) for being at risk for losing physical independence.
Logistic regression was used to estimate the univariate and multivariate odds of OH for the subgroups of patients based on their diagnosis.
Logistic regression was used to examine the association between dietary patterns and clinically significant cognitive impairment.
Logistic regression was used to identify factors associated with 30-day mortality.
Logistic regression was used to identify socioeconomic and health variables associated with change in dementia prevalence between @number@ and @number@
Logistic regression was used to identify the risk factors for children's anemia.
Logistic regression was used to relate presence of a fall in the previous year with the number and latency of postural adjustments.
Logit regressions were used to assess the impact of diabetes , comorbidities , and functional status on the frequency of nursing home admission.
Log-linear regressions were adjusted for a priori selected covariates to determine differences by frailty and HIV status.
LogMAR analysis highlighted statistical significance between the two acuity sets ( p < @number@ ) to an unanticipated data spread.
LogMAR minimum VA appeared to be significantly related to the tear clearance rates in subjects @number@ years and older ( p < @number@ ) .
Log multinomial regression was used to estimate the relative risk of single and multiple falls associated with gait measures.
Log ( neopterin ) correlated with log ( IL-6 ) ( correlation coefficient = @number@ P < @number@ ) .
Log ( neopterin ) was significantly associated with prevalent frailty , adjusting for log ( IL-6 ) .
Logopedists could be involved in providing these exercises.
Logopenic patients show a unique pattern of spared and impaired language processes that reliably distinguish this syndrome from other variants of progressive aphasia.
Logopenic variant patients showed reduced activation of posterior superior temporal cortex to phonemic spectral structure.
Logopenic variant primary progressive aphasia and developmental dyslexia both manifest with phonological disturbances and posterior temporal involvement.
Log plasma esRAGE was not significantly associated with log IL-1β , log TNF-α , IL-6R , log IL-18 , or CRP.
Log ( SIF ) correlated more with mean HbA1c as the time period increased.
Log-transformed IL-6 , TNF-α , and CRP were analyzed using ANCOVA.
LOH is defined by reduced serum testosterone levels ( either total testosterone or free testosterone ) .
LOH is often comorbid to obesity and several chronic diseases.
LOH was defined as low libido , diminished frequency of morning erections and erectile dysfunctions in men with total testosterone < 12 nmol / l.
LOH was diagnosed in @percent@ prediabetic men and in @percent@ control men.
London : MIT Press , @number@ ] .
London : Routledge ) .
Lone AF was diagnosed in @number@ patients ( @percent@ ) .
Loneliness among older people is an issue that engages the general public and various professions and organizations in contemporary Swedish society.
Loneliness among the elderly is explained by the lack of Gemeinschaft and its characteristics in contemporary society.
Loneliness and feelings of social isolation were prevalent.
Loneliness and SMAs were assessed with the Loneliness Scale of De Jong Gierveld and the SMAS-30 , respectively.
Loneliness is a common experience among older people that is associated with health risks and negative well-being.
Loneliness is a significant public health topic and clinicians should be aware of the various factors that can affect loneliness.
Loneliness is commonly perceived as significantly related to ageing and older people.
Loneliness , isolation from society and neglect of parents by children is a big problem to many people in old age.
Loneliness is seen as an unpleasant experience that occurs when a person's network of relationships is felt to be deficient in some important way.
Loneliness may influence cognitive function , but the exact nature of the association between loneliness and cognitive function is poorly understood.
Loneliness was also found to cross-sectionally predict self-rated health , although this relationship was not present at a longitudinal level.
Loneliness was assessed by means of the three-item UCLA Loneliness Scale.
Loneliness was closely related to living alone , to depression , and to region ( northern Sweden ) .
Loneliness was measured by the short version of the UCLA-Loneliness-Scale in a face-to-face interview.
Loneliness was measured by using a three-item questionnaire.
Loneliness was measured using a three-item loneliness scale based on the University of California at Los Angeles ( UCLA ) Loneliness Scale.
Loneliness was not associated with mortality among the participants aged 70-78 , 78-85 , and 85-90.
Loneliness was reported by @percent@ of respondents at Waves 3-6.
Long-acting testosterone undecanoate significantly improved the mental health component of QoL in men with TDS.
Long- and short-term TC training were positively associated with physical function.
Long ATXN2 polyQ repeats ( ≥33Qs ) were not present in any of the ALS patients or controls.
Long-chain acyl-coenzyme A ( CoA ) synthetase @number@ ( ACSL3 ) is an androgen-responsive gene involved in the generation of fatty acyl-CoA esters.
Longer and larger studies are needed to better clarify the role of TRT in such chronic conditions.
Longer and shorter lifespans were accompanied by increased and decreased investments of energy into somatic maintenance , respectively.
Longer ART duration was associated with thinning of inferior and nasal RNFL quadrants ( p-trend = @number@ and @number@ respectively ) .
Longer disease duration , prior biologics use , and treatment without MTX co-therapy were associated with EULAR no response.
Longer duration of rehabilitation and improved pain management may be necessary for functional improvement and goal attainment.
Longer ED delirium duration is associated with an incremental worsening of 6-month functional and cognitive outcomes.
Longer evaluation is required to evaluate longer-term safety and demonstrate duration of effect beyond @number@ months.
Longer exposure to FOF was associated with an increased risk of functional decline.
Longer exposure to numbers and quantity-related problems may progressively refine numerical skills , similar to what happens to other cognitive abilities like verbal memory.
Longer follow-up generally is considered favorable in such studies , but associations of interest may become attenuated with increasing follow-up.
Longer follow-up is required to examine the impact of protein on bone loss.
Longer follow-up may detect changes over time.
Longer life , lower fertility , and population aging all raise the demand for wealth needed to provide for old-age consumption.
Longer lifespan means dermatologic needs will increase as the skin must perform its basic function longer.
Longer lives and extended retirement have created a ' young old age ' stage of life.
Longer multi-site studies are recommended to explore the risk factors for and the permanence of these longer-term cognitive effects.
Longer postdiagnosis survival among racial / ethnic minorities compared with whites persisted after adjustment for comorbidities.
Longer presentation times were associated with better performance in all age groups , presumably reflecting increasing effects of strategic selection mechanisms on WM performance.
Longer starvation times were positively , but not significantly , associated with higher infection rates , but were negatively associated with feeding and survival.
Longer stride and faster cadence were protective against meaningful decline in usual walking speed.
Longer studies are needed to assess durability and tolerability.
Longer studies in large populations should help to better define indications , treatment modalities and long-term treatment safety.
Longer telomeres at baseline were not predictive for all-cause mortality , cardiovascular mortality , or cancer mortality.
Longer telomeres might increase cancer risk.
Longer term trials with long chain omega-3 supplementation in early stage AD are warranted.
Longer time since diagnosis , but not age at diagnosis , was associated with continued decline in working memory , a common sign of aging.
Longer work experience and greater county occupancy rates were associated with a larger performance gap.
Longevity and age at estimated onset among those receiving and not receiving antidepressants were compared.
Longevity and healthy aging are among the most complex phenotypes studied to date.
Longevity associated genes ( LAGs ) may be operationally defined as genes that confer beneficial effects and are relatively more conserved among long-lived species.
Longevity assurance mechanisms might thus delay DNA damage-driven aging by raising the threshold when accumulating DNA damage becomes detrimental for physiological tissue functioning.
Longevity evaluation indexes are used to analyze the longevity phenomenon in @number@ towns between @number@ and @number@
Longevity factors promote stress resistance and cellular survival.
Longevity increases when FoxO becomes activated in response to reduced insulin / IGF-1 signalling.
Longevity index ( LI% ) and centenarity index ( CI% ) may be as index to evaluate the longevity level.
Longevity in this study population is not compromised by the cumulative effect of this set of risk alleles for common disease.
Longevity is a very complex phenomenon , because many environmental , behavioral , socio-demographic and dietary factors influence the physiological pathways of aging and life-expectancy.
Longevity is different for every animal species as well as their genome , suggesting a correlation between genes and life-span.
Longevity is the ability to cope and repair the damage that results from these changes.
Longevity should be considered physiologically as a new phase of life , characteristic of the well adapted subject.
Longevity , supported by the progress and availability of medical care to the population , has been unveiling this phenomenon during recent decades.
Longevity will become a significant burden for developed countries already within the next 10-20 years.
Long interspersed element @number@ ( L1 ) is an autonomous non-LTR retroelement that is active in mammalian genomes.
Long interspersed element @number@ ( L1 ) is the only currently active autonomous retroelement in the human genome.
Long interspersed elements @number@ ( L1 ) are active mobile elements that constitute almost @percent@ of the human genome.
Longissimus thoracis et lumborum ( LTL ) sections were vacuum packaged and aged for @number@ @number@ @number@ @number@ @number@ and @number@ days.
Longitudinal ( 3-5 yearly ) follow-up is planned.
Longitudinal administration of neuropsychological instruments are often used to assess age-related changes in cognition.
Longitudinal analyses revealed a significant effect of sex , with girls showing stronger fear-potentiation at all pubertal stages.
Longitudinal analyses showed positive associations for α-linolenic acid with increased knee extension strength ( P-trend : @number@ ) .
Longitudinal analysis found no evidence of reverse causality.
Longitudinal analysis indicated that this was in part due to aging , while changes in GFR had a less pronounced effect on serial biomarker measurements.
Longitudinal analysis revealed that RLPFC-IPL SC , but not FC , was a positive predictor of future changes in reasoning ability.
Longitudinal and circumferential strains were computed offline with high spatial resolution using a customized commercial speckle-tracking software and finite element analysis.
Longitudinal associations between FSRP and its components were tested using mixed-effects models , and rates of cognitive change over @number@ years were estimated.
Longitudinal beta-alanine ( BA ) supplementation is suggested to enhance physical capability during exercise ; however , these effects have not been evaluated in MA.
Longitudinal change indicated that individuals with PD with dementia declined significantly more rapidly on visuospatial and verbal memory tasks than AD alone.
Longitudinal change in the epigenetic clock estimates and the fitness variables were assessed via linear mixed models and latent growth curves.
Longitudinal changes in cognitive function were expressed as 1-year decline in CDT performance.
Longitudinal changes in DNAm age are highly variable across individuals after initiation of antiretroviral therapy.
Longitudinal changes in glucagon suppression were investigated in @number@ participants undergoing a lifestyle intervention.
Longitudinal changes in LDCW did not predict subsequent incident HF or mortality.
Longitudinal changes in parameters were analyzed using linear mixed-effects models.
Longitudinal changes in slope of decline in specific cognitive test measures can serve as non-invasive methods for the detection of pAD.
Longitudinal change was assessed by the ( T2 - T1 ) difference between scores on the @number@ occasions.
Longitudinal , circumferential , and radial peak systolic strain values were determined by means of speckle tracking.
Longitudinal community-based studies using diagnostic measures are needed to further clarify relationships among common mental disorders , aging , and sleep.
Longitudinal data analyses were performed using a generalized linear model.
Longitudinal data from those involved on both data collection occasions ( N = @number@ ) was used.
Longitudinal data of age-related traits can be used in association studies to test for polymorphisms that predict how an individual will change over time.
Longitudinal data of skeletal muscle mass were analyzed using a general linear mixed-effect model.
Longitudinal data on @number@ African-American urban adults participating in the Healthy Aging in Neighborhood of Diversity across the Lifespan study were used.
Longitudinal data was acquired from the Alzheimer's Disease Neuroimaging Initiative ( ADNI ) study from phases GO and @number@ ( 2009-2015 ) .
Longitudinal data were analyzed by hierarchical models.
Longitudinal data were analyzed with a multivariate mixed-effects model.
Longitudinal data were obtained from @number@ prospective cohort studies.
Longitudinal data with specific stress measures are needed to further evaluate the impact of work schedule on rTL.
Longitudinal designs are an important tool to understand how neighborhood contexts influence health and health disparities.
Longitudinal epidemiologic studies with irregularly observed categorical outcomes present considerable analytical challenges.
Longitudinal follow-up is needed to evaluate the risk of subsequent hemorrhage in cases of incidentally discovered SS.
Longitudinal follow-up is needed to test whether altered iron homeostasis in the HC is an early marker for age-related cognitive decline.
Longitudinal follow-up of T2DM subjects without overt dementia using both amyloid imaging and magnetic resonance imaging may elucidate these issues.
Longitudinal growth occurs within the long bones at the growth plate.
Longitudinal imaging studies involve tracking changes in individuals by repeated image acquisition over time.
Longitudinal imaging studies offer the possibility to model temporal change trajectories of anatomy across populations of subjects.
Longitudinal increase in hs-CRP was also associated with a higher risk of MI.
Longitudinally assessing how HIV infection and ART initiation affect biomarkers of end organ function / disease could clarify these mechanisms.
Longitudinally , effect sizes were not significantly different in any of the @number@ ROIs tested.
Longitudinally , logistic regressions showed that engagement in physical activities was a significant predictor of stability of cognitive status.
Longitudinally , more variation was observed in the rate of LTL change during the shorter than longer follow-up periods.
Longitudinally , participants with self-reported HF at baseline showed declines in reasoning over time.
Longitudinal models of CD4 cell restoration examined associations with age-group , thymic volume , immune activation , and viral load.
Longitudinal multicohort studies are needed to unequivocally differentiate aging from disease progression.
Longitudinal normative data obtained from a robust elderly sample ( i.e. , believed to be free from neurodegenerative disease ) are sparse.
Longitudinal observations are required to determine if TL is affected by AS.
Longitudinal profiles of cognitive decline in PD and AD differed.
Longitudinal , questionnaire-based data were collected from three age cohorts ( born in 1926-30 , 1936-40 , and 1946-50 ) living in southern Finland.
Longitudinal rates and patterns of change in scores on a standard cognitive battery were compared between these two groups.
Longitudinal regression discontinuity modeling was used to examine performance and decline in episodic memory.
Longitudinal research is needed to confirm these pathways.
Longitudinal research is needed to confirm this finding and to identify potential mediators.
Longitudinal research might enhance the sensitivity of this test to identify preclinical impairment and persons at risk of mild cognitive impairment and dementia.
Longitudinal research should be conducted to explore the mechanisms through which childhood abuse and its subtypes links with elder abuse.
Longitudinal research should be required to determine whether aging and long-term health events can change the nature of resilience.
Longitudinal research with markers of disease severity is needed to investigate loss of physical function with aging , and to develop age-specific HIV care guidelines.
Longitudinal results were parallel.
Longitudinal series of age-standardized mortality rates for overall , breast and prostate cancers were modeled by Joinpoint regression to estimate the annual percent change.
Longitudinal strain ( LS ) normal mean values varied from @number@ to @number@ ( mean , @number@ @percent@ CI , @number@ to @number@ ) .
Longitudinal strain was also inversely related to carotid-femoral pulse wave velocity and other risk factors for higher aortic stiffness including treated hypertension.
Longitudinal structural models revealed that age-20 interaction quantity had a direct , unmediated effect on age-50 social and psychological outcomes.
Longitudinal studies are necessary for validation of data and to further clarify the relevance of TMV.
Longitudinal studies are needed to assess the relation of cognitive activity to change in neurocognitive function in older persons with HIV.
Longitudinal studies are needed to better understand temporal relationships between physical frailty , health and QoL.
Longitudinal studies are needed to confirm our findings and determine whether anxiety treatment improves neurocognitive outcomes in CVD.
Longitudinal studies are needed to determine if olfactory performance predicts future mobility and functional decline.
Longitudinal studies are needed to determine whether Aβ predicts gait decline in both women and men.
Longitudinal studies are needed to determine whether improving glycemic control to HbA1c < 9% leads to fewer limitations in daily activities due to incontinence.
Longitudinal studies are needed to determine whether these findings reflect channeling of short-acting agents to residents at higher risk of sleep disorders.
Longitudinal studies are needed to differentiate between age and birth cohort effects.
Longitudinal studies are needed to evaluate the impact of drug interactions on health-related outcomes.
Longitudinal studies are needed to examine the causal impact of social networks on various domains of health.
Longitudinal studies are needed to explore the mechanisms through which self-neglect links with suicidal ideation.
Longitudinal studies are needed to further evaluate the relationship between inflammation with changes in skeletal muscle AT distribution with aging and the incidence of T2DM.
Longitudinal studies are needed to further investigate the contributions of VR to cognitive decline among older BD patients.
Longitudinal studies are needed to gain more insight into the natural history of psychiatric illness in adults with PWS.
Longitudinal studies are needed to obtain a more comprehensive understanding of the pathways between PF and EM and its subtypes among Chinese aging populations.
Longitudinal studies are needed to study the causality of the findings.
Longitudinal studies are needed to test the potential causal association between food insecurity , lack of virologic suppression , and additional HIV outcomes.
Longitudinal studies are recognized as contributing to understanding the complexity of aging and generating insights that cannot be gained using other research methods.
Longitudinal studies are recommended to further examine the causal relationship of spiritual activity and cognitive function.
Longitudinal studies are required to determine how the different HRQOL domains evolve over time in NH residents.
Longitudinal studies are required to determine the effects of increased and decreased anticholinergic load on cognitive function and other clinical outcomes for people with dementia.
Longitudinal studies are required to establish the causal association of early life adiposity with biological aging.
Longitudinal studies are warranted to clarify the relationship between tau deposition and vascular health.
Longitudinal studies assessing age-related changes using high-resolution peripheral quantitative computed tomography ( HR-pQCT ) provide novel insight compared with cross-sectional analyses.
Longitudinal studies can assess change over time and specific disease endpoints.
Longitudinal studies fail to consistently show developmental trajectories between ADHD and BD.
Longitudinal studies have contributed substantially to understanding of aging and geriatric syndromes.
Longitudinal studies have reported accelerated LTL attrition when baseline LTL is longer.
Longitudinal studies of CSF NfL in FTD are warranted.
Longitudinal studies of objectively measured physical activity are lacking in older adults.
Longitudinal studies on aged healthy and cancer persons and the use of new immunological techniques may be required to clarify these issues.
Longitudinal studies on the change of fiber tract integrity in normal and pathological aging are still rare.
Longitudinal studies should examine whether visible PVS predate WMH progression and whether inflammation modulators can prevent small vessel disease.
Longitudinal studies suggest that leading an intellectually challenging , physically active , and socially engaged life may mitigate losses and consolidate gains.
Longitudinal studies will prove which method better predicts cardiovascular or renal events.
Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers.
Longitudinal studies with repeated assessments are needed to understand the temporal relationship between ANA , aging-associated diseases , and mortality.
Longitudinal study designs are indispensable for investigating age-related functional change.
Longitudinal study designs are necessary to further establish the impact of age.
Longitudinal study of antiretroviral therapy ( ART ) -treated HIV-infected and uninfected participants from the Multicenter AIDS Cohort Study and Women's Interagency HIV Study.
Longitudinal study of the heartbeat in small animals contributes to understanding structural and functional changes during heart development.
Longitudinal systolic strain rate ( LSRs ) was significantly determined by the age and RS by the type of vendor used.
Longitudinal VBM demonstrated that the progression of GM atrophy in PPMS occurs at different rates in different regions across the brain.
Longitudinal work is required to establish the relationship between identified age-associated genes / pathways and aging-related diseases.
Long-lasting type @number@ and type @number@ diabetes mellitus ( DM ) are both associated with impaired cognitive function in humans.
Long lived flies expressing Hsp22 also have an increased resistance to oxidative stress and maintain locomotor activity longer.
Long-lived , GH-deficient Ames mice displayed elevated humanin levels , while short-lived GH-transgenic mice have reduced humanin levels.
Long-lived individuals delay aging and age-related diseases like diabetes , hypertension , and cardiovascular disease.
Long-lived Th1 CD4 ( + ) T cells are essential for protective immunity against pertussis.
Long-living individuals ( LLIs ) are used to study exceptional longevity.
Long-living persons show its decrease that is more marked in men.
Long noncoding RNAs ( lncRNAs ) have emerged as critical epigenetic regulators of gene expression.
Long QT syndrome was defined as corrected QT ≥450 ms.
Longstanding arterial pulsation in the central artery causes elastin fiber fatigue and fracture.
Long-standing serum L levels , and in particular L supplementation , were the strongest determinants of MPOD.
Long-stay residents identified by the algorithm were compared with the NH evidence from MDS-alone and Medicare parts A and B data.
Long-term BACKGROUND : Previous studies have linked both extreme and sub-optimal air temperature to cardiopulmonary morbidity and mortality , especially in older individuals.
Long-term care and survival were determined from two follow-ups.
Long-term care ( LTC ) needs to be reconceptualized.
Long-term care ( LTC ) policy in particular is built on specific assumptions about women and caregiving.
Long-term care of the disabled elderly imposes a substantial burden on families.
Long-term care practitioners can help residents deflect negative stereotypes and improve their own attitudes about aging.
Long-term care residents should be considered at high risk of vitamin D deficiency and therefore vitamin D supplementation is highly recommended in this population.
Long-term challenges are associated with practical and emotional concerns.
Long-term changes in perceived constraints , but not in personal mastery , also predicted SMC.
Long-term combination therapy with alpha blockers ( doxazosin , terazosin ) improves symptoms significantly better than finasteride monotherapy.
Long-term consequences of anesthetic exposure in humans are not well understood.
Long-term consumption of fatty foods is associated with obesity , macrophage activation and inflammation , metabolic imbalance , and a reduced lifespan.
Long-term diabetes prevention is successfully feasible within the narrow financial frame of a legal insurance system without rise of costs.
Long-term economic conclusions cannot be drawn from these data.
Long-term efficacy and safety have not been well documented.
Long-term efficacy appeared good in the few studies that reported it.
Long-term endurance training was associated with reduced leukocyte telomere erosion compared with untrained controls.
Long-term engraftment of uMSCs in the kidney was not observed either.
Long-term ( especially > @number@ years ) TC survivors may have difficulty maintaining optimal vitamin D levels.
Long-term evolution of the PR interval and related factors were obtained during follow-up of this population.
Long-term exposure to air pollution is associated with age-related diseases.
Long-term follow-up consists of examining overall efficacy with attention to associated adverse events.
Long-term follow-up of patients to ascertain fully the value of post-cancer serum AMH in predicting long-term ovarian function is required.
Long-term follow-up studies are warranted to investigate the cardiovascular safety of testosterone treatment in this specific population.
Long-term habitation in space leads to physiological alterations such as bone loss , muscle atrophy , and cardiovascular deconditioning.
Long-term hypertrophy of the LH cells results in their functional decline after the age of @number@
Long-term imaging of inclusion-bearing neurons and neighboring neurons without inclusions demonstrates selective degeneration of inclusion-bearing cells.
Long-term interventions produced superior weight loss ( @number@ kg ) compared to short-term ( @number@ kg ) and intermediate-term ( @number@ kg ) interventions.
Long-term mortality of subjects with ACOS is similar to COPD , and worse than asthma and healthy controls.
Long-term neurological outcomes are generally good.
Long-term nursing home residence was defined using a validated algorithm based on Medicare Part B claims for nursing home-related care.
Long-term or even permanent survival of individuals and societies can be achieved when profound understanding of control mechanisms becomes a reality.
Long-term outcomes of this program have not been described.
Long-term outcomes should be measured to determine the impact of this apparent discrepancy in care.
Long-term paracetamol treatment is common in the elderly , despite a potential cysteine / glutathione deficiency.
Long-term patterns of change in physical activity ( PA ) and their influence on body composition decline during aging has not been characterized.
Long-term physical activity may affect risk of cognitive impairment but few studies have examined later life cognition in relation to intensity of life-long physical activity.
Long-term physiological effects of cigarette smoke are through chronic and not acute exposure.
Long-term PPI treatment is associated with an increased risk of fractures in the general population.
Long-term safety could not be determined.
Long-term safety data were limited.
Long-term smoking exposure could lead to more advanced coronary endothelial dysfunction and atherosclerosis possibly via oxidative stress.
Long-term studies with larger sample sizes are warranted to determine whether testosterone supplementation affects atherosclerosis progression and cardiovascular risk.
Long-term survival shifted the attention towards neurological problems , disability and carcinogenesis of radiotherapy.
Long-term survival was @percent@ , @percent@ , and @percent@ at @number@ @number@ and @number@ years after surgery , respectively.
Long-term tadalafil safety data did not reveal clinically relevant differences between age groups.
Long-term therapeutic trials are important to elucidate this issue.
Long-term training could improve the inflammatory-endocrine imbalance associated with disease , frailty , functional decline , and mortality in elderly men.
Long-term training effects remain to be investigated.
Long-term trajectories in BP may assist in more accurate identification of individuals with subclinical atherosclerosis.
Long-term treatment may be required , but the long-term risks with osteoporosis drugs remain incompletely understood.
Long-term treatment with bisphosphonates has been related to atypical femoral fractures.
Long-term trials are needed to better evaluate the benefit of bariatric surgery in aging obese patients.
Long-term use of melatonin is still open in climacteric syndrome.
Long-term use remained high with @percent@ in @number@ and @percent@ in @number@ of total benzodiazepine use.
Long-term utilisation of broad-spectrum antibiotic therapy is being followed in order to control these infections.
Long-wavelength solar UV radiation is implicated in photodamage to the human eye.
Lon levels also decline with age and with senescence , and senescent cells even lose the ability to induce Lon during acute stress.
Looking beyond the intervertebral disc , we describe the different ways to classify pain in human patients and animal models.
Looking to the future , advances in genome science are opening new opportunities for sociogenomic epidemiology.
Looking towards the future , this review focuses on how nanoscale tissue engineering can be and is being used to influence that local environment.
Loop diuretics , nitrates , digoxin , hydralazine and amiodarone may be used when patients do not respond to initial therapy.
Loop diuretic use may be associated with recurrent falls and needs further study.
Loosely-bound zinc ions in the photoreceptors might play a role in the phototransduction cascade and rhodopsin regeneration.
Losartan , an AT1 receptor antagonist , and inhibitors of either mitogen-activated protein kinases or phosphoinositide 3-kinase prevented the MP-induced endothelial senescence.
Losing older employees to retirement drains knowledge and expertise.
Losses in accuracy and area under ROC curve between maximum and minimum k were limited to @percent@ and @percent@.
Losses of lean tissue with dieting typically tend to be small , raising questions about study design , power and applied measurement method reliability.
Losses to follow-up ( approximately @percent@ ) were excluded from the prevalent population.
Loss of a functional MUTYH protein will result in the accumulation of G : T mismatched DNA caused by oxidative damage.
Loss of astroglial function and astroglial reactivity contributes to the aging of the brain and to neurodegenerative diseases.
Loss of balance was induced by releasing participants from a static forward lean.
Loss of BLBP ( + ) stem / progenitor cells correlates with reduced neurogenesis in aging rodents and postnatal humans.
Loss of bone and muscle with advancing age represent a huge threat to loss of independence in later life.
Loss of bone mineral density occurs in patients with diabetes , but is not always a priority in the practice setting.
Loss of cardiac macroautophagy / autophagy impairs heart function , and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease.
Loss of cardiomyocytes because of injury or diseases leads to heart failure , which is a major cause of human morbidity and mortality.
Loss of chromosome cohesion , which is a feature of oocytes from older females , causes altered kinetochore geometry in meiosis-I.
Loss of cognitive function and hypertension are two common conditions in the elderly and both significantly contribute to loss of personal independency.
Loss of cognitive function is one the most devastating manifestations of ageing and vascular disease.
Loss of coital function is rarely a reason for regret.
Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling.
Loss of collagen is a natural development accompanying aging of the body.
Loss of collagen organization , impaired viability of fibroblasts , depletion of stem cells pool , and reduced mechanical properties have been observed.
Loss of E-cadherin expression is a crucial step of epithelial-mesenchymal transition ( EMT ) and is involved in cancer invasion and metastatization.
Loss of family members and displacement from pre-earthquake residence were significant risk factors for psychological distress in older men.
Loss of fat , coupled with gravity and muscle pull , leads to wrinkling and the formation of dynamic lines.
Loss of fine skin patterning is a sign of both aging and photoaging.
Loss of function mutations in MIP have been identified in human centronuclear myopathy.
Loss of function mutations in RAB39B were recently linked to X-linked recessive early-onset Parkinsonism with variable degrees of intellectual dysfunction.
Loss-of-function mutations in the KATP channel genes KCNJ11 and ABCC8 cause neonatal hyperinsulinism in humans.
Loss-of-function mutations in the PINK1 gene lead to recessive forms of Parkinson's disease.
Loss-of-function mutations in two riboflavin transporter genes , SLC52A2 and SLC52A3 , have recently been linked to Brown-Vialetto-Van Laere syndrome.
Loss of function of a different small GTPase , UNC-108 , on the contrary , leads to the retention of APL-1 in the cell body.
Loss of function of either protein results in the progressive accumulation of unesterified cholesterol in every tissue leading to cell death and organ damage.
Loss of function of this gene in a T-DNA insertion mutant resulted in decreased seed longevity.
Loss-of-function progranulin ( PGRN ) mutations have been identified as the major cause of frontotemporal lobar degeneration with TDP-43 protein inclusions ( FTLD-TDP ) .
Loss-of-function variants were found in TBK1 in @number@ cases and no controls and , separately , in NEK1 in @number@ cases and no controls.
Loss of healthy bone tissue and dysosteogenesis are still common and significant problems in clinics.
Loss of homeostasis is caused by increased expression of sirtuin @number@ ( Sirt4 ) , a Lsd1-repressed direct target gene.
Loss of imprinting ( LOI ) is an epigenetic event that relaxes an allele-specific restriction on gene expression.
Loss of MIP function results in a syndrome which consists of LVNC , DD , seizures , hypotonia , and cataracts.
Loss of MNK protein itself downregulates total eIF4E1 protein level by reducing eIF4E1 mRNA polysomal loading without affecting total mRNA level or stability.
Loss of muscle mass is an unfavourable consequence of aging and many chronic diseases.
Loss of muscle occurs as a consequence of many chronic diseases ( cachexia ) , as well as normal aging ( sarcopenia ) .
Loss of muscle on day @number@ was related to decreases in pennation angle.
Loss of musculoskeletal mass and function is a natural ageing trait , reinforced by an unhealthy life style.
Loss of olfactory function is common in old age , but evidence regarding qualitative olfactory dysfunction in the general older population is scarce.
Loss of OSG-1 gene function was not associated with developmental defects.
Loss of ovarian function induces a reduction in resting metabolic rate , physical energy expenditure , fat-free mass and abdominal adipose tissue accumulation.
Loss of p16INK4A in Foxp1-deficient MSCs partially rescued the defects in replication capacity and bone mass accrual.
Loss of PARL impairs proteolytic maturation of Smac , which fails to bind XIAP.
Loss of PAX2 is the earliest known molecular aberration in the FTE occurring in serous carcinogenesis followed by a mutation in p53.
Loss of P-gp expression or activity may serve as a selective biomarker for ongoing capCAA.
Loss of photoreceptors is a common endpoint in degenerative retinal diseases.
Loss of PKB signaling contributes to diabetes , whereas gain of function of PKB drives cancer.
Loss of PKP2 caused decreased INa and NaV1.5 at the site of cell contact.
Loss of RB function and MYC activation are thought to control both overlapping and distinct cellular processes during cell cycle progression.
Loss of retinal ganglion cells follows a slowly progressive sequence.
Loss of senescence due to the absence of p21 is partially compensated by apoptosis but still results in detectable developmental abnormalities.
Loss of sensory functioning can lead to increased risk of falls in challenging postural tasks , especially in older adults.
Loss of Sirt4 expression leads to decreased cellular ATP levelsin vitro and in vivo while Sirt4 overexpression is associated with increased ATP levels.
Loss of SIRT5 leads to accumulation of medium- and long-chain acylcarnitines and decreased β-hydroxybutyrate production in vivo.
Loss of skeletal muscle mass and function results in loss of mobility for elderly patients.
Loss of skeletal tissue as a consequence of trauma , injury , or disease is a significant cause of morbidity with often wide-ranging socioeconomic impacts.
Loss of spouse and increasing comorbidity did not affect the social support score.
Loss of SPRTN results in failure to repair DPCs and hypersensitivity to DPC-inducing agents.
Loss of STK3 / STK4 impairs autophagy in diverse species , indicating that these kinases are conserved autophagy regulators.
Loss of subcutaneous fat is a hallmark of ageing usually starting in the face.
Loss of such homeostasis due to abnormal signaling networks as in aging could lead to diseases such as osteoarthritis.
Loss of synapses is a hallmark of the neuropathology of early Alzheimer's disease ( AD ) .
Loss of the antioxidative capacity of ascorbate increases oxygen levels 3-fold at the lens surface.
Loss of the integrity and plasticity of neuronal morphology and connectivity comprises an early step in neuronal degeneration and ultimate decline of cognitive function.
Loss of the p53 tumor suppressor , a nuclear transcription factor , is also known to contribute to prostate malignancy.
Loss of Tif1g in mouse HSCs favored the expansion of the granulo-monocytic progenitor compartment.
Loss of trabecular bone was already evident in young adulthood and continued throughout life.
Loss of vascular smooth muscle cell ( VSMC ) function is a hallmark of vascular disease.
Loss of vision in severe retinal degenerations often is a result of photoreceptor cell or retinal pigment epithelial cell death or dysfunction.
Loss of visual function is one of the most important quality of life measures for older adults.
Loss of volume in the soft tissues of the face is considered to be an important cause of facial ageing.
Loss of volume in the temple can result in a gaunt , wasted appearance.
Loss of weight was defined as decrease over time in BMI of at least @number@ kg / m ( @number@ ) per year.
Loss of WRN gives rise to the Werner syndrome , a genetic disease characterised by premature aging and cancer predisposition.
Loss of WRN increased DNA damage in both cell types as measured by COMET assay , but elicited different responses in each cell line.
Loss was observed in the temporoparietal cortex in both typical and atypical AD , and showed significantly greater loss than FTLD.
Lost years of working life expectancy were calculated for demographic and clinical characteristics.
Loupe magnification is used.
Low 25 ( OH ) D levels correlated with high body fat , glucose levels and decreased insulin sensitivity.
Low 5-HTT gene-expression has also been suggested to increase the risk of chronic pain.
Low and high compliance were defined as ≤ @percent@ and ≥ @percent@ of provided ONS actually consumed , respectively.
Low Aβ42 / Aβ40 was related to less GM in the thalami , caudate , and midbrain.
Low back and neck pain were the most common diagnoses both in the general population and as reason for health care utilization.
Low back pain and osteoarthritis affects over two thirds of this group.
Low back pain , in its acute and chronic forms , is one of the most common health problems and is frequently evaluated by rheumatologists.
Low back pain more commonly results in some kind of consequence when compared to NP and MBP.
Low baseline dispositional optimism was strongly associated with loneliness over time , also in the adjusted analysis.
Low birth weight and a high incidence of preterm birth program Indigenous children for early onset renal disease in adult life.
Low birth weight individuals have strong correlations with increased susceptibility to type @number@ diabetes and cardiovascular disease in later-life.
Low birth weight is associated with cardiovascular disease and its risk factors , including heart rate and blood pressure.
Low blood levels of B vitamins have been implicated in age-associated cognitive impairment.
Low BMD at the lumbar spine is associated with a lower incidence of knee OA although it does not arrest the progression of knee OA.
Low BMD ( BMD Z score ≤ @number@ ) was present in @percent@ of cases , but after height adjustment in @percent@ of cases.
Low bone density is a growing concern in aging men with hemophilia and may result in high-morbidity fragility fractures.
Low bone density is a risk factor for hyperkyphosis , and each vertebral fracture adds roughly 4° to forward spine curvature.
Low bone volume and changes in bone quality or microarchitecture may predispose individuals to fragility fractures.
Low calcium intake is a widespread problem across countries and age groups.
Low calcium intake was observed in @percent@.
Low circulating pyridoxal @number@'-phosphate ( PLP ) concentrations have been linked to inflammatory markers and the occurrence of inflammatory diseases.
Low complexity ( LC ) prion-like domains are over-represented among RNA-binding proteins ( RBPs ) and contribute to the dynamic nature of RNA granules.
Low concentrations of DNA-damaging drugs induce p53 at levels that do not inhibit mTOR , thus causing senescence.
Low-contrast acuities stretched from 20 / 25 to 20 / 125.
Low cortical metabolic activity in the right lateral , inferior , and medial temporal cortex was associated with poorer memory.
Low-cost gaming technology offers promising devices for the rehabilitation of stroke patients at home.
Low D.cort and C.Th were associated with higher prevalence of vertebral fractures regardless of aBMD.
Low dopamine levels and death of the dopaminergic neurons are hallmarks of Parkinson's disease ( PD ) , where α-synuclein is also a key player.
Low-dose aspirin acts as an antiplatelet agent by causing an irreversible inactivation of platelet COX-1 activity and the synthesis of thromboxane A2.
Low-dose aspirin use , which increases the likelihood of gastrointestinal bleeding , is common in the target population for colorectal cancer screening.
Low doses ( @number@.1-100 µM ) of SUAs did not affect cholesterol efflux from macrophages despite dose-dependent increases in ABCA1 / G1 expression.
Low educational attainment may be an indicator of long-term SES trajectories , and be associated with accumulated allostatic load resulting in telomere shortening.
Low education , poor financial condition , and lack of physical and leisure activities showed a crude association with risk for malnutrition.
Low energy hip dislocation is rare and usually associated with hip abnormalities.
Lower aerobic fitness was associated with greater RT variability , and this effect increased with age.
Lower age-related CBF rate was unrelated to brain volume and was observed only in val homozygotes of COMTval158met.
Lower amplification was associated with poorer Stroop processing , working memory , and recognition memory.
Lower baseline bioavailable testosterone levels and more rapid declines in bioavailable testosterone were associated with more rapid increases in prostate volume.
Lower baseline CR fitness was associated with progression of dementia severity in AD.
Lower birth weight and body length were associated with higher fasting glucose , insulin , HOMA-IR and HbA1c among old non-diabetic individuals.
Lower-body functioning was assessed using four performance-based measures.
Lower body negative pressure seemed to create comparable hypovolemia measured as total calf volume increase in elderly and young women.
Lower bond strength was obtained for PBNT when a dry-bonding technique was used , regardless of the oxalate treatment ( P < @number@ ) .
Lower clustering values and lower degree values were specifically associated with worse mini-mental state examination scores and lower performance on the neuropsychological tests.
Lower cognitive capacity - as determined by the fluid intelligence measure - was significantly associated with greater hearing loss.
Lower cognitive scores in those with less education were seen at baseline for the first two groups.
Lower consumption of dietary protein was found at breakfast and dinnertime compared with the recommended amount of 25-30 g ( P < @number@ ) .
Lower CO was associated with worse performance in processing speed ( P = 0.015 ) and executive function ( P = 0.003 ) .
Lower CS score was also associated with thin temporal RNFL in HIV-infected individuals ( p = @number@ ) .
Lower demyelination correlated with higher P300 amplitude ( p = 0.0002 ) .
Lower DHEA ( r range : @number@ to @number@ ) and testosterone ( r range : @number@ to @number@ ) concentrations associated with higher fatigue.
Lower doses of BoNTA significantly improved the static and dynamic glabellar lines in the Chinese.
Lower earnings and high medical expenditures caused by current poor health status prevent households from accumulating savings for future health adversities.
Lower E / A was defined as measures under the 25th percentile of sample distribution ( 0·784 ) .
Lowered intake of particular nutrients rather than of overall calories is also key , with protein and specific amino acids playing prominent roles.
Lower-educated day workers demonstrated poorer cognitive ability in early adulthood than lower-educated shift workers , who may have selected jobs entailing higher cognitive demand.
Lower-educated shift workers performed better on cognitive tests than lower-educated day workers at retirement.
Lower educational attainment generally is a strong predictor of coronary heart disease ( CHD ) .
Lower education , income , physical activity levels and smoking were associated with low scores.
Lower education , more adverse psychosocial working conditions and any physical disorder were negatively associated with this intention.
Lower environmental QOL was significantly associated with female gender , impaired PADL , depression and anxiety.
Lower esophageal sphincter pressure ( LESP ) , primary peristalsis ( PP ) , and secondary peristalsis ( SP ) were evaluated.
Lower expression of lymphocitic hTERT mRNA may easily cause cell aging , which is not beneficial to maintaining a durable lymphocyte division.
Lower extremity muscle strength was determined using a manual dynamometer.
Lower-extremity neuropathy symptoms were self-reported.
Lower-extremity physical performance was measured using the Short Physical Performance Battery , a summary score of balance , chair stand ability , and walking speed.
Lower extremity surgical procedures in patients with Werner's syndrome are uncommon , and for this reason they are rarely reported in the literature.
Lower extremity symptoms included numbness or tingling and aching or burning pain.
Lower eyelid blepharoplasty is one of the most common procedures in aesthetic plastic surgery.
Lower eyelid prominence occurs as an aging process.
Lower fan was more common in males.
Lower fertility and mortality are associated with higher human capital investment per child , also raising labor productivity.
Lower flow rates ( @number@ and @number@ mL min ( @number@ ) ) were associated to smaller extent of dispersion.
Lower fluence , longer pulse durations , and careful device selection can mitigate the risk of scarring and pigmentary abnormality.
Lower frequencies of slow oscillations of the posturographic signals can be removed using high-pass filtering.
Lower frequency-elicitation of PGCR , PUCR , and RPS in the elderly can predispose them to the risks of aspiration.
Lower gain was associated with higher FA in the LF range ( P = 0.001 ) .
Lower gastrointestinal endoscopy did not modify the association of smoking and colorectal cancer risk among current smokers and among the more recent quitters.
Lower Hb levels , therefore , were associated with depression in the elderly men.
Lower hemoglobin ( Hb ) levels are a common feature in the elderly.
Lower IgA levels were associated with being atopic ( P < @number@ ) .
Lower income and education were also associated with nutritional risk.
Lower inferior temporal cortical thickness was predictive of greater apathy.
Lowering aspirations and support seeking were not associated with well-being outcomes.
Lowering basal autophagy reduces GABs , whereas increasing autophagy decreases mature autolysosomes.
Lowering of PSL-PSU correlation with increased age was also demonstrated , showing modest interrelation among younger men and no interrelation in older population.
Lowering the magnesium concentration weakens the inhibition.
Lowering the presentation level of the L-span task had a greater detrimental effect on the older adults than on the younger ones.
Lower initial functional ability of nTBI patients on admission and patients ' different clinical profiles have implications for clinical care and resources.
Lower intratumoral levels of EGFR , pyruvate kinase M2 , β-catenin , hexokinase @number@ and p-glycoprotein were also observed.
Lower in vivo caudate volume was also associated with higher prediction error.
Lower IQ scores among children who later developed obesity were present as early as @number@ years of age.
Lower isometric strength was associated with PSLL , but not mortality.
Lower Klotho concentrations were associated with the detection rate of calcifications in the heart valves and large arteries ( the abdominal aorta ) .
Lower LAEF was associated with older age , higher transmitral E / A ratio and higher NT-proBNP.
Lower late-life BMI may be a preclinical indicator of underlying ADNP.
Lower levels of behavior problems were predicted by improvements in maternal depressive symptoms.
Lower levels of eGFR ( SCr ) were not associated with higher risk of prevalent or incident frailty.
Lower levels of FT3 , FT4 and TSH were found in centenarians ' children and nieces / nephews with respect to age-matched controls.
Lower levels of haemoglobin , serum zinc and physical activity were associated with higher nutrition risk.
Lower lid hyperpigmentation in the smoking group fell just short of statistical significance.
Lower limb function was assessed using the Short Physical Performance Battery.
Lower lingual strength in healthy adults may predispose them to aspiration.
Lower LVSV was associated with worse performance in processing speed ( P = 0.043 ) and executive function ( P < 0.001 ) .
Lower memory scores were linked to smaller HC and higher HC iron concentration.
Lower Mini-Mental State Exam and episodic memory scores correlated most strongly with higher concentrations of soluble and insoluble Aβ1-42.
Lower MMSE score at baseline was associated with greater risk of incident stroke.
Lower motor neuron involvement is usually less prominent in types @number@ and @number@ than in type @number@
Lower motor neuron loss and TDP-43-positive skeinlike inclusions were observed in all pathological subtypes.
Lower mtDNA copy number is also associated with prevalent frailty. mtDNA copy number is a significant predictor of all-cause mortality in a multiethnic population.
Lower mtDNA copy number was also significantly associated with prevalent frailty in white participants from CHS ( OR @number@ @percent@ CI @number@.85-0.97 ) .
Lower muscle mass and strength are also associated with lower bone mineral density and greater risk for osteoporotic fractures.
Lower neighborhood SES indicators were associated with more utilitarian walking and higher rates of falls on sidewalks , streets , and curbs.
Lower P1NP / βCTX ( < 100 ) and hypoalbuminemia could be useful simple additive prognostic tools for fracture risk stratification in the elderly.
Lower PAS scores correspond to higher proprioceptive acuity.
Lower physical QOL was observed even in individuals with borderline low ABI ( @number@ to @number@ n = 426 ) .
Lower PON1 activity was related to higher level of inflammation indicators - hsCRP and IL-6.
Lower ponderal index ( PI ) was associated with a higher rate of CHD-related hospital in-patient care during the time period.
Lower processing speed , general cognitive functioning , and delayed memory recall were associated with disagreeing with a remaining need for intimacy when getting older.
Lower proportions of male responders on the Facial Wrinkle Scale / Merz Aesthetics Scales were consistent with results from onabotulinumtoxinA and abobotulinumtoxinA GFL studies.
Lower psychological QOL was significantly associated with impaired PADL , impaired cognition , depression and anxiety.
Lower rates of catheter misplacement have been reported after right IJV puncture , probably for its straight vertical course.
Lower respiratory tract disease is common and may result in respiratory failure ( 8-13% ) or death ( 2-5% ) .
Lower respiratory tract infections ( LRTIs ) are a major cause of morbidity in children.
Lower SBP treatment levels may result in improved cognition in black patients.
Lower SEP in childhood is detrimental to cognitive and physical capability in midlife , at least in part , independently of subsequent SEP in adulthood.
Lower social QOL was significantly associated with depression and anxiety.
Lower socio-economic status , physical inactivity and current smoking were the most robust predictors of non-participation in the health assessment.
Lower SOC was associated with problems in all EQ-5D dimensions and moderate / severe disability as measured by the BI.
Lower step frequency at the maximum pace was also associated with lower normalized-rCMRglc in these regions.
Lower synthesis and absorption of cholesterol , and low serum cholesterol level are associated with deteriorating health and indicate impaired survival in old age.
Lower systemic blood flow may have implications for dementia among older adults.
Lower tertile of FA and upper tertile of MD were significantly associated with faster Mini-Mental State Examination decline.
Lower T levels are associated with aortic , peripheral vascular , and cardiovascular disease in middle-aged and older men.
Lower total Protein S was a consistent marker of non-AIDS death.
Lower urinary tract dysfunction-such as urinary incontinence ( UI ) , detrusor overactivity , and benign prostatic hyperplasia-is prevalent in elderly persons.
Lower urinary tract symptom ( LUTS ) was assessed using OABSS and voiding diary.
Lower values were found in patients with metabolic syndrome.
Lower vasodilatation had a negative impact on exercise capacity , particularly prevalent in patients with sarcopenia.
Lower vitamin D levels were also associated with increased WASO in age-adjusted , but not multivariable adjusted models.
Lower zeaxanthin to lutein ratios were measured in groups at risk for age-related macular degeneration ( eg , older participants , females ) .
Lowest ePiB values were found in MCI of @number@ years and older , who also displayed high cortical PiB binding.
Lowest quartiles of IGF-1 and IGFBP-1 were considered as reference.
Low EZH2 levels reduce H3K27 methylation , prevent MUS81 recruitment at stalled forks and cause fork stabilization.
Low femoral and lumbar spine BMD was defined as < 25th percentile value for the study cohort.
Low folate and raised homocysteine levels are risk factors for dementia , including Alzheimer's disease , and depression.
Low frequencies of hearing and cognition may share similar common and unique environmental factors.
Low-frequency coding variants , not detected by GWAS , are predicted to include functional variants with larger effects on risk.
Low-frequency hearing was up to about @number@ dB poorer in the most recently studied cohort compared to the previously studied cohorts.
Low frequency of going outdoors was also associated with FoF ( OR @number@ @percent@ CI : @number@ @date@ ) .
Low-functioning and sarcopenia states were more likely to lead to death ( @percent@ and @percent@ ) .
Low functioning MAOA genotypes have been reliably linked to increased reactive aggression , yet the psychological mechanisms of this effect remain largely unknown.
Low GOLT1A levels were correlated with better survival in patients with breast cancer.
Low-grade , chronic inflammation has been associated with many diseases of aging , but the mechanisms responsible for producing this inflammation remain unclear.
Low-grade inflammation and endothelial dysfunction accounted for only @percent@ explained variance in cognitive functioning , on top of related vascular risk factors and cardiovascular disease.
Low-grade inflammation and endothelial dysfunction are related to cognitive decline and dementia , in a complex interplay with vascular factors and aging.
Low handgrip strength was significantly associated with all-cause mortality among older men and women from the general population after controlling for significant confounders.
Low health was associated with enhanced fear of death for participants who received only little social support.
Low hemoglobin levels among patients may alert clinicians to the increased risk of frailty.
Low hopelessness scores also predicted greater resilience in both groups.
Low information literacy might be an obstacle of using such systems.
Low-intensity stress will activate p53 in a manner which results in antioxidant response , thus protecting against ageing because of its antioxidant function.
Low-intensity training that emphasizes muscle coordination reduces variability in older adults.
Low Kappa values may have resulted , in part , from a low prevalence of clinical signs and symptoms in the study participants.
Low klotho on admission may be secondary to low IGF-1 levels and may contribute to the clinical manifestations of AN.
Low lathosterol , sitosterol , and cholesterol predicted mortality additively and independently of each other.
Low-level alcohol consumption significantly increased the risk of hyperechoic parenchymal foci , main pancreatic duct ( MPD ) dilatation and wall hyperechogenicity.
Low-level CIM was already detectable in @number@ of the @number@ non-neoplastic mucosa samples of CD patients and in non-CD-associated carcinomas of elderly patients.
Low levels of deletion were found ( mean ΔCt = @number@ ) .
Low levels of DHEAS accompany adrenal suppression.
Low levels of education , insufficient income , depressive symptoms , and low scores of cognitive function were all significantly related to lower LSA scores.
Low levels of mitochondrial DNA multiple deletions were found in all muscle biopsies.
Low levels of physical activity ( PA ) are reported to contribute to the occurrence of non-communicable diseases over the life course.
Low levels of TFAM lead to first-phase OXPHOS dysfunction.
Low levels of vitamin D were associated with cognitive decline.
Low lung function is a feature of several pulmonary disorders , such as uncontrolled asthma and chronic obstructive pulmonary disease.
Low mean ankle strength was associated with increased incidence of falling ( P = @number@ ) .
Low , medium , and high settings are preprogrammed in the device , and they indicate the strength of resurfacing.
Low memory self-efficacy believers activated more brain areas involved in visuospatial operations such as the hippocampus.
Low MetS risk group , BP risk group , BP-HDL risk group , and BP-FPG-TG risk group were found.
Low mitochondrial oxidative capacity causes muscular fat accumulation , which impedes insulin signaling via lipid intermediates , in turn affecting oxidative capacity.
Low molecular weight peptides derived from the breakdown of crystallins have been reported in adult human lenses.
Low muscle function , an essential component of sarcopenia , is associated with negative outcomes , including falls , fractures , and dependency.
Low muscle mass was assessed by two measures : midarm muscle circumference ( MAMC ) and fat-free mass index ( FFMI ) .
Low muscle mass was associated with greater deterioration of bone than in deterioration of glucose or lipid profiles.
Low muscle mass was defined as muscle mass minus two standard deviations below the mean for young healthy adults.
Low muscle mass was determined using specific SMI cut-offs for Japanese individuals.
Low numeracy has been associated with difficulties in understanding risk-benefit information and making health decisions.
Low or high hematocrit levels are associated with increased morbidity and mortality , mediated via anemia or thromboembolic events , respectively.
Low PAFs suggest changes in health-related behaviours in older women would result in only modest reductions in common chronic conditions.
Low perceived social support predicted the probability of poor SRH in women ( OR = @number@ @percent@ CI = @number@ @date@ ) .
Low performing older adults did not receive a benefit of sleep on the visuospatial task.
Low-performing older adults used this network to a lesser extent.
Low PhA moreover predicted 1-year mortality in the Cox proportional hazards regression model , whereas grip strength was no longer significant.
Low physical performance and activity limitations are more prevalent in patients with CKD , regardless of age , compared to older community-dwelling adults.
Low physical performance was defined as the lowest @percent@ of study sample in each sex.
Low PI and disk instability due to degeneration may contribute to the development and progression of retrolisthesis.
Low population frequencies of risk alleles in tissue banks make it impractical to study their function in cells derived from autopsied tissue.
Low prevalence rates in middle-aged adults are also more likely to be valid.
Low priorities , for both the public and professionals , were the actual measurements of patient-centred care delivery and its impact on outcomes.
Low-quality evidence shows no difference for IFN-α plus bevacizumab compared to sunitinib with respect to mortality and severe AEs.
Low rates of virologic failure and no ATV resistance mutations were observed in these clinical trials.
Low regional CBF was most frequent in subjects with daytime STDE.
Low-risk alcohol intake and living with a partner were positively associated with \ "good health \ ".
Low scores for specific photodamage parameters including erythema / telangiectasias , hyperpigmentation , and wrinkling were also significantly associated with vitamin D insufficiency.
Low scores may indicate a younger biologic arterial age associated with a low risk for incident cardiovascular disease.
Low serum 25-hydroxy-vitamin D ( 25 ( OH ) D ) has been suggested as biomarker of frailty in literature.
Low serum klotho was shown to be related to grip strength and disability.
Low serum levels of @number@ hydroxyvitamin D ( 25OHD ) ( hypovitaminosis D ) is common in older adults and associated with several negative outcomes.
Low serum total cholesterol is frequently associated with worse survival in older people , but mechanisms of this association are poorly understood.
Low SMI does not seem to be a prerequisite for low strength or limitations in mobility.
Low socioeconomic status increases difficulties in accessing formal care.
Low socioeconomic status ( SES ) has been associated with higher levels of allostatic load ( AL ) .
Low socioeconomic status ( SES ) may be associated with accelerated biological aging , but findings relating SES with telomere length have been inconsistent.
Low sun exposure and inadequate dietary vitamin D consumption were associated with a low vitamin D status in females and males , respectively.
Low sympathetic index ( @number@ ) of ITA may be associated with fewer incidences of sympathetic nervous systems problems ( vasospasm ) of the ITA.
Low TC ( < 5.5 mmol / l ) is associated with the highest mortality rate in 80 + -year olds.
Low testosterone is a risk factor for impaired glucose tolerance ( IGT ) in men.
Low testosterone is a very weak predictor of a diagnosis of T2D.
Low testosterone is a weak predictor of a diagnosis of T2D.
Low threshold symptom-based definitions resulted in nearly universal diagnosis of MUI.
Low tolerability potentially reduces persistence and adherence , while inducing switching between medications.
Low to subnanogram / ml sensitivity for proteins in plasma was achieved by one-step immunoaffinity depletion of @number@ abundant plasma proteins prior to analysis.
Low urine pH predisposes to uric acid stone formation.
Low-vision aids are described and sources for these products are identified.
Low vitamin D and K status are both associated with an increased cardiovascular risk.
Low vitamin D has also been shown to be associated with decline of muscle strength , sarcopenia , functional limitation , and disability.
Low vitamin E status has been linked to multiple health outcomes , including total mortality.
Low VitD did not predict 12-year cognitive decline.
Low volume SR-WBV exercises over @number@ training sessions with @number@ Hz , Noise @number@ seems a sufficient stimulus to improve ETGUG total time.
Low zinc levels in serum were related with OS and cellular aging and were , in turn , to be a risk factor for hypertension.
L-PHP has recently been discovered to affect a broad array of gene expression in the pancreas including growth factor genes.
L-PHP receptor type-1 has been identified in pancreas which provides a possibility for L-PHP autocrine and paracrine regulation in pancreatic function.
LPL polymorphisms and triglycerides were determined and CVD assessed.
LP mean value was around @number@ μm , also with narrow limits of ranging in AgGr and more extended individual limits.
LPS.
LPS alone.
LPS alone.
LPS induced the secretion of TNF-α and IL-1β from THP-1 human monocyte-like cell line and RAW264.7 mouse macrophages.
LPS-induced TNF-α and IL-1β production by leptomeningeal cells through inhibiting the nuclear factor-κB signaling pathway.
LPS induces posttranslational modifications of TDP-43 ; in particular , TDP-43 ubiquitination provides a driving force for InSAC formation.
LPS / PA treatment also boosted adipogenesis of MSCs and suppressed osteogenesis.
LPS / PA treatment significantly increased NLRP3 expression , decreased SIRT1 expression and promoted caspase-1 activity in MSCs.
LPS-stimulated leptomeningeal cells were significantly higher than those after P.g.
LPS-stimulated RAW264.7 macrophages were significantly higher than those after treatment with P.g.
LPS treatment consistently increased TF transcript and protein expression.
L. rhamnosus was detected in adults ( P < 0·001 ) , but not in any elderly person.
LRP1 is known to be an endocytic receptor for multiple ligands including Aβ.
LRP1 knockdown in primary astrocytes resulted in decreased cellular Aβ uptake and degradation.
LRP5 was upregulated in human and mouse OA cartilage , and Lrp5 deficiency in mice inhibited cartilage destruction.
LRR13 is a novel inhibitory epitope and may be useful for developing anti-TLR4 antibodies.
LRRK2 , a gene relevant to Parkinson's disease , encodes a scaffolding protein with both GTPase and kinase activities.
LRRK2 can function as a protein kinase and mutations lead to increased kinase activity.
LRRK2 G2019S carriers ( n = @number@ ) and non-carriers ( n = @number@ ) were similar in age and age at onset of PD.
LRRK2 is a multidomain protein with kinase and GTPase activities.
LRRK2 parkinsonism patients had slightly less gastrointestinal dysfunction and rapid eye movement sleep disorder.
LRRK2 p.G2019S mutation is a useful aid to diagnosis and modifiers of disease in LRRK2 parkinsonism may aid in developing therapeutic targets.
LRRK2 phosphorylation , however , particularly at serine @number@ was reduced with clinical Parkinson's disease with a @percent@ reduction measured in the substantia nigra.
LSA scores below @number@ correspond to \ "restricted life-space. \ "
LS BA increased significantly from @number@ years from PHV to @number@ years from PHV , whereas LS BMC increased until @number@ from PHV.
LSC score was created by the use of seven social connection measures.
Lsh represses endogenous p16 ( INK4a ) expression by recruiting HDAC to the p16 ( INK4a ) promoter , which in turn delays cell senescence.
LST would be useful for preventing sarcopenia in older individuals.
LS was significantly increased during institutional routines ( mealtimes ) as compared to the rest of the day.
LTC in the occlusion at T-2 steps condition was significantly greater than that in other conditions.
LTC is one of the most pressing fiscal issues for the growing population of elderly people in the European Union ( EU ) Member States.
LTFU was defined as having no primary HIV visits in the year after the 22nd birthday.
LTFU was prevalent at each age transition , with factors associated with LTFU similar to that identified for 21-year-olds.
LTL and CRP were assayed from leukocyte DNA and serum specimens , respectively.
LTL correlated with leukocyte mtDNA content in our studied elderly ( r = @number@ p = @number@ ) .
LTL dynamics are defined by LTL and its age-dependent attrition.
LTL dynamics ( birth LTL and its age-dependent attrition thereafter ) mirror telomere dynamics in hematopoietic stem cells ( HSCs ) .
LTL elongation in longitudinal studies primarily reflects measurement errors of LTL in relation to the duration of follow-up periods.
LTL heritability was estimated to be between @percent@ and @percent@ , suggesting a strong genetic predisposition to interindividual variation of LTL in this population.
LTL shortening has correlated with decreased longevity , dementia , and other age-associated processes.
LTL ( T / S ratio ) was quantified by qPCR.
LTL was analyzed using quantitative polymerase chain reaction.
LTL was assayed from whole blood using the quantitative polymerase chain reaction method relative to standard reference DNA.
LTL was assessed in @number@ adults from the Netherlands Study of Depression and Anxiety.
LTL was assessed using quantitative polymerase chain reaction ( qPCR ) .
LTL was assessed using real-time PCR during the 10-year follow-up period ( @date@ to @date@ ) .
LTL was inversely associated with age in both cohorts.
LTL was inversely associated with HOMA-IR ( p = @number@ ) and age ( p = @number@ ) .
LTL was measured by qPCR and SMTLs by southern blot.
LTL was measured by quantitative polymerase chain reaction.
LTL was measured by Southern blots of the terminal restriction fragments.
LTL was measured using a quantitative PCR method at a mean age of @number@ years.
LTL was measured using the real-time quantitative polymerase chain reaction methodology.
LTL was measured with a quantitative polymerase chain reaction method.
LTL was not associated with number or type of endocrine abnormalities in this study.
LTL was unassociated with clinical cataract outcomes.
LT training decreased percentage body fat and fasting levels of plasma glucose , while increasing high-density lipoprotein cholesterol and lecithin-cholesterol acyltransferase levels.
LT was defined as a single measurement of TT of < 300 ng / dL.
Lubiński and Gólczewski recently presented a piecewise linear model with constants and coefficients claimed to be physiologically interpretable ( Lubiński model ) .
Lucidin-3-O-primeveroside ( LuP ) is an anthraquinone derivative present in madder root , which has been used as a coloring agent and food additive.
Luciferase assay revealed that EMS inhibits the transcriptional activity of NF-κB by stabilizing IκB.
Luciferase experiments indicated BECN1 , but not ATG5 as a direct target of miR-216a.
Luciferase promoter assays demonstrate that FoxO1 directly activates SIRT1 promoter activity and that both the IRS-1 and FKHD-L enable FoxO1-dependent SIRT1 transcription.
Lumbar aBMD is low in both trained and recreational cyclists.
Lumbar degenerative scoliosis is a complex pathology as it often involves the intersection of degenerative spinal stenosis and spinal deformity.
Lumbar disk degeneration was documented according to the Pfirrmann classification system.
Lumbar extensor muscle strength was measured in the upright posture with a load cell.
Lumbar intervertebral discs ( IVDs ) are prone to degeneration upon skeletal maturity.
Lumbar IVD degeneration on MRI of the @number@ IVDs from which surgical specimens had been obtained was classified into five grades using the Pfirrmann classification.
Lumbar lateral radiograph , sagittal balance and spinal mobility determined with SpinalMouse ( ® ) and back muscle strength were measured.
Lumbar postural changes of each patient were examined in the aspects of pattern and excursion , considering those from the healthy subjects as reference.
Lumbar puncture for testing of Alzheimer's disease pathophysiology for diagnostic confirmation is likely to become more common in the coming years.
Lumbar scans identified @number@ trained and @number@ recreational cyclists as osteopenic and @number@ trained cyclists as osteoporotic.
Lumbar spine BMD did not change from baseline to Year @number@
Lumbar spine lordosis was quantified as the angle between the inferior endplate of L1 and superior endplate of S1.
Lumbar spine motion was compared between patients with and without SNs via independent t test among @number@ individuals with qualified kinematic images.
Lumbar stenosis is one of the more common radiographic manifestations of the aging process , leading to narrowing of the spinal canal and foramen.
Luminance contrast of scenes was equalized between stimuli using a root-mean square ( RMS ) contrast normalization.
Lumps were reported in all but one study but received little follow-up.
Lunch was consumed after the @number@.5-h blood draw.
Lung cancer accounts for more cancer deaths than breast , prostate , colorectal and pancreatic cancer combined.
Lung cancer is notorious for its ability to metastasize , but the pathways regulating lung cancer metastasis are largely unknown.
Lung cancer is one of the most common and lethal cancers and tobacco smoking remains its most important etiologic factors.
Lung cancer is the leading cancer site in males , comprising @percent@ of the total new cancer cases and @percent@ of the total cancer deaths.
Lung cancer is the leading cause of cancer deaths in Japan.
Lung cancer is the most common cause of cancer-related mortality in the United States.
Lung cancer patients with cardiovascular complications often require antithrombotic therapy.
Lung cancer remains the leading cause of cancer-related mortality in the United States.
Lung cancer treatment in patients @number@ years and over is a major issue of thoracic oncology.
Lung function decline has not previously been investigated in relation to menopause.
Lung function diminishes as a function of normal aging , and the effects of early lung injury from cancer therapy may compound these changes.
Lung function measures of FEV1 , FVC , FEV1 / FVC , and PEF were derived from spirometry.
Lung function predicts mortality ; whether it is associated with functional status in the general population remains unclear.
Lung tissue remodeling in chronic obstructive pulmonary disease ( COPD ) is characterized by airway wall thickening and / or emphysema.
Lutein and zeaxanthin food contents were separated into lutein and zeaxanthin in the nutrient database.
Lutein is also the predominant carotenoid in human brain tissue and lutein status is associated with cognitive function in adults.
Luteinizing hormone ( LH ) administered in pharmacological amounts downregulates Leydig cell steroidogenesis.
Luteinizing hormone ( LH ) is a pituitary heterodimeric glycoprotein essential in male and female reproduction.
Lutein uptake and secretion was also assessed in Caco-2 cells.
LUTS would represent for ED an independent risk factor.
Luxatemp showed the lowest colour alteration regardless its thickness and Duralay showed the greatest alteration with @number@ mm.
Luxury services ( e.g. heated swimming pools ) were indicated as least likely to encourage relocation.
LV 3D strain parameters were also influenced by LV volumes and mass , image quality , and temporal resolution ( P < @number@ ) .
L values over white background and a values over black background of the enamel dentine complex seem to change with age.
LV compliance was assessed by the slope of the pressure-volume curve.
LV CSF Mean diffusivity was greater in males than females ( ( ~1.2% ; p = 0.03 ) .
LV EF and concentricity increased with greater age in both sexes.
LVEF had no apparent effect on maintenance dose and should not be considered a contraindication to use.
LVEF was lower in males than in females ( @percent@ vs. @percent@ , P = @number@ respectively ) .
LV global longitudinal strain , global circumferential strain , and torsion indices were analyzed using 3-dimensional echocardiography.
LVH was assessed from baseline electrocardiograms by measuring the Sokolow-Lyon index.
LVM and LVF were evaluated in animals and humans by echocardiography and LVM index ( LVMI ) was obtained.
LV mass and dynamic volume were measured using the area-length method.
LV mass and volumes were assessed.
LV mass , supine PCWP , and heart rate were not affected significantly by aging.
LV mass was calculated as ( LV epicardial volume - LV endocardial volume ) × @number@
LV mass was no longer associated with cognition in multiple regression.
LVMI in children was similar in both genders.
LVRR was defined as LV end-diastolic dimension ≤ @number@ mm and fractional shortening ≥ @percent@ at the last echocardiogram.
LV / RV morphology and function were evaluated by steady-state free-procession ( SSFP ) sequence.
LVSIsys remains stable throughout age groups , whereas LVSIdia progressively increases with age.
LV stiffness was assessed by the slope of LV pressure-volume curve.
LV stiffness was calculated from a curve fit of the diastolic portion of the pressure-volume curve.
LV strain was also measured by using Vsp two-dimensional ( 2D ) and vendor-independent 3D speckle-tracking echocardiographic software packages , for comparison.
LV volumes and corresponding long-axis diameter were measured throughout the cardiac cycle.
LV volumes decreased with greater age in both sexes , even after indexation.
LV volumes estimated using both T1-weighted and DTI correlated strongly in males and females ( ICC = 0.99 ; median Dice index ~80% ) .
LXA4 and RvD1 levels in CSF correlated with Mini-Mental State Examination ( MMSE ) scores.
LXA4 receptor ( FPR2 / ALX ) was detected by immunostaining of HCE cells and human corneal tissue using a polyclonal antibody.
LX and ATL exert potent bioactions on leukocytes , vascular and epithelial cells to stop inflammation and promote resolution.
LXRs play essential roles in the development and progression of cardiovascular diseases.
LY379268-induced increase of PPAR-γ levels could be involved in the effect of the agonist on sAPPα release.
Ly-6 / neurotoxin ( Lynx ) proteins have been shown to modulate cognition and neural plasticity by binding to nAChR subtypes and modulating their function.
LYC also significantly elevated antioxidant enzymes activities and reduced levels of inflammatory cytokines in the d-galactose-treated mice serum.
LYC ameliorated histopathological damage and restored brain derived neurotrophic factor ( BDNF ) levels in the hippocampus of mice.
Lycogen™ treatment also prevented the UVA-induced MMP-1 upregulation and intracellular MDA generation in Hs68 cells.
Lycopene has been identified as an antioxidant agent with potential anticancer properties.
Lycopene , lutein , and other carotenoids have anti-oxidant activity that attenuates the inflammatory atherosclerotic process and delays vascular aging.
Lycopene ( LYC ) , a carotenoid pigment , possesses potent antioxidative , anti-inflammatory , and neuroprotective properties.
Lying between adjacent vertebrae , it provides both the primary support and the elasticity required for the spine to move stably.
Lymphangioleiomyomatosis ( LAM ) is a rare , potentially fatal disease primarily affecting young women.
Lymphatic contractile dysfunction is central to a number of pathologies that affect millions of people worldwide.
Lymphatic dysregulation leads to inflammation , scarring , and fibrosis , but inadvertent injection of these vessels can be avoided with anatomical knowledge.
Lymphatics were seen and were orientated differently in the geriatric vocal folds.
Lymphatic vessels , along with the surrounding distinct perilymphatic fat , traveled directly beneath wrinkles and creases.
Lymphatic vessels were identified by positive immunofluorescence as well as histological criteria.
Lymph nodes enlargement was least likely in adenovirus type @number@
Lymphocytes predominantly express two ERM members , ezrin and moesin.
Lymphocyte subpopulations were analyzed in blood samples collected every four hours for @number@ hours.
Lymphocyte subpopulations were phenotyped by flowcytometry before and after culture.
Lymphocyte subsets commonly associated with stress , sleep impairment and immunosenescence were phenotyped by flow cytometry.
Lymphocyte subsets [ T , natural killer ( NK ) and NKT ] were phenotyped by flow cytometry.
Lysine acetylation and deacetylation are posttranslational modifications that are able to link extracellular signals to intracellular responses.
Lysine acetylation / deacetylation has been recognized as an important posttranslational modification regulating numerous cellular processes.
Lysine-directed PTMs including ubiquitylation , acetylation , and methylation play key regulatory roles with respect to the rates of tau turnover and aggregation.
Lysines on ubiquitin ( Ub ) determine fates of Ub-protein substrates.
Lysis indices of < 85% were observed in nearly one-third of all children without increased bleeding tendency.
Lysosomal storage disorders ( LDS ) comprise a group of rare multisystemic diseases resulting from inherited gene mutations that impair lysosomal homeostasis.
Lysosomal-β-galactosidase ( GLB1 ) hydrolyzes β-galactose from glycoconjugates and is the origin of senescence-associated β-gal activity ( SA-β-gal ) .
Lysyl hydroxylases and lysyl oxidases regulate tissue-specific crosslinking patterns and quantities.
M1 anodal tDCS in this population appears to be effective to reduce pain , but not to improve sleep.
M2-like macrophages accumulated in AMD , but not in normal eyes , suggesting that these macrophages may be linked to macular degeneration.
M2PD values were generally lower than S2PD values.
MA-5 facilitates mitochondrial ATP production and reduces ROS independent of ETC by facilitating ATP synthase oligomerization and supercomplex formation with mitofilin / Mic60.
MA-5 has potential as a drug for the treatment of various mitochondrial diseases.
MA-5 reduced mitochondria fragmentation , restores crista shape and dynamics.
MA and YG had similar quadriceps muscle MRT-volume or PT and maximal oxygen uptake as well as a normal cardiovascular risk factors and intima-media-thickness.
MAAS enrollees also received the SF-36 at both time points.
MACE independent risk factors were based on the Andersen-Gill multiplicative intensity model.
Machado-Joseph Disease ( MJD ) , also known as spinocerebellar ataxia type @number@ ( SCA3 ) , represents the most common form of SCA worldwide.
Machine learning dynamic Bayesian graphical models were used to identify and simulate predictors and outcomes.
Machine order was randomized.
MAC-Q score < 15 out of @number@ defined severe cognitive complaint.
Macro- and microvascular complications are currently the principal causes of morbidity and mortality in patients with diabetes mellitus.
Macroautophagy delivers large aggregates and whole organelles to lysosomes by first enveloping them into autophagosomes that then fuse with lysosomes.
Macroautophagy has been shown to protect cells from unfavorable environmental conditions and extend lifespan of various cells and organisms.
Macroautophagy is a cellular process by which cytosolic components and organelles are degraded in double-membrane bound structures upon fusion with lysosomes.
Macroautophagy is a fundamental and evolutionarily conserved catabolic process that eradicates damaged and aging macromolecules and organelles in eukaryotic cells.
Macroautophagy is a lysosomal catabolic process that maintains the homeostasis of eukaryotic cells , tissues , and organisms.
Macroautophagy is a lysosome-dependent degradation pathway which widely exists in eukaryotic cells.
Macroautophagy is a major intracellular degradation process recognized as playing a central role in cell survival and longevity.
Macroautophagy is an evolutionarily conserved lysosomal-dependent pathway of degradation of several cytoplasmic components , such as misfolded proteins or damaged organelles.
Macroautophagy plays important physiological roles during development and aging processes and also contributes to immune responses.
MacroH2A1.1 over-expressing cells display ameliorated glucose metabolism , reduced expression of lipidogenic genes and fatty acids content.
Macronutrient and energy intakes were compared and data such as weight , height , diet type and medical history were obtained from medical records.
Macronutrients and micronutrients deficiencies are associated with frailty.
Macrophage coordinates functioning of immune system , participates in tumor growth progression.
Macrophage depletion or TNF blockade in conjunction with αCD40 / IL-2 prevented cytokine storms in young obese mice and protected from lethality.
Macrophage dysfunction plays a pivotal role during neovascular proliferation in diseases of ageing including cancers , atherosclerosis and blinding eye disease.
Macrophage inhibitory cytokine-1 ( MIC-1 / GDF15 ) is a marker of inflammation that has been associated with atherosclerosis.
Macrophage inhibitory cytokine-1 ( MIC-1 / GDF15 ) is a member of the TGF-b superfamily , previously studied in cancer and inflammation.
Macrophage markers ( CD68 , CD163 , and CD206 ) in SAT , VAT , and the liver from patients with obesity were investigated.
Macrophage ( Mϕ ) phagocytosis of bacteria plays a critical role in the clearance of pathogens and the initiation of immune responses.
Macrophages belong to the innate immune system and as such constitute one of the first barriers against infection.
Macrophages constitute a heterogeneous cell population described by many names , with varying phenotypic characteristics , depending on their tissue location and state of activation.
Macrophages of mPGES-1 ( - / - ) PyMT mice indeed expressed elevated levels of CD80 compared to their wildtype counterparts.
Macrophages were present in greater quantities in DC specimens ( @number@ vs. @number@ macrophages / high power field ; P < 0.05 ) .
Macrophages were previously implicated in the pathogenesis of neovascular age-related macular degeneration ( nvAMD ) .
Macroscale differences in tendon organization were not observed , although cell density and nuclear shape did vary between age groups.
Macroscopic infarcts were found in @number@ ( @percent@ ) people , and microinfarcts were found in @number@ ( @percent@ ) people.
Macroscopic mechanical properties of human skin in vivo cannot be considered independent of adjacent subcutaneous white adipose tissue ( sWAT ) .
Macro vascular-complications were found to be related with decreased levels of NG1 ( @number@ ) A2F.
Macular cysts , ERMs , and FTMHs were associated with visual impairment.
Macular pigment ( MP ) selectively filters short-wave light and may improve visual performance via this mechanism.
Macular sensitivity was examined by a standard grid , a 37-stimuli grid covering the central @number@ degrees of the retina including one centering point.
MAD experienced by illegitimate children was @number@ y ( @percent@ CI : [ @date@ @number@ ] ) shorter than of legitimate children.
MafB is a basic leucine zipper transcription factor that plays important roles in development and differentiation processes.
Magazine content would benefit from including more empirical evidence , culturally sensitive content , and physical activity recommendations that are consistent with U.S. guidelines.
Magnesium appears to play the protective role in the occurrence of metabolic disorders.
Magnesium is essential for metabolism of nitric oxide which helps in penile erection.
Magnetic fields were measured using a 160-channel , whole head MEG.
Magnetic field therapy and physical activity have been proven as beneficial interventions for prevention and treatment of osteoporosis.
Magnetic resonance images of @number@ normal and healthy participants between the ages of 21-45 years were acquired.
Magnetic resonance imaging analyses revealed that rs8070723 ( MAPT ) was associated with gray matter variance in the temporal cortex.
Magnetic resonance imaging and diffusion kurtosis imaging of the hippocampus were performed.
Magnetic resonance imaging is used to assess structure and function in the hippocampal formation.
Magnetic resonance imaging is used to provide anatomical descriptions , but at this time only clinical examination and neuropsychological testing can assess white matter functioning.
Magnetic resonance imaging ( MRI ) and positron emission tomography ( PET ) provide structural and functional information.
Magnetic resonance imaging ( MRI ) has become an important noninvasive method for characterizing hip anatomy and pathology in these patients.
Magnetic resonance imaging ( MRI ) has become an important tool in the early detection of age-related and neuropathological brain changes.
Magnetic resonance imaging ( MRI ) is an important paraclinical tool to diagnose and monitor multiple sclerosis ( MS ) .
Magnetic resonance imaging ( MRI ) of cerebral microbleeds is the most reliable option for clinical diagnosis of suspected CAA.
Magnetic resonance imaging ( MRI ) was rated visually for the presence of MTA and PA.
Magnetic resonance imaging ( MRI ) was used to quantify changes of IMTG , abdominal sub-depots , hepatic and intermuscular fats.
Magnetic resonance imaging of the orbit indicated fat density in continuity with intraorbital fat in the area of protrusion.
Magnetic resonance imaging provides objective biomarkers in the diagnosis of brain injury by detecting brain lesions resulting from trauma.
Magnetic resonance imaging revealed an intrasellar cystic mass with suprasellar extension.
Magnetic resonance imaging revealed the cervical cord compressed by pachymeningeal hypertrophy.
Magnetic resonance imaging revealed the enlarged posterior pituitary with thickened stalk.
Magnetic resonance imaging showed only widespread cortical atrophy.
Magnetic resonance imaging was performed , and regional grey matter ( GM ) volumes were obtained.
Magnetic resonance imaging was used to calculate total ischemic lesion and brain volumes.
Magnetic Resonance Imaging was used to study changes in the crystalline lens and ciliary body with accommodation and aging.
Magnetic resonance imaging with diffusion tensor was performed at years @number@ and @number@
Magnetic resonance ( MR ) -based R2 mapping enables the in vivo detection of iron content in brain tissue.
Magnetoencephalography ( MEG ) provides information on human brain functions with the excellent temporal ( ms ) and spatial ( mm ) resolution.
Magnification of task visual feedback increases force variability in older adults.
MAHTs requested this mixed methods study to understand the progression of cases through the public sector.
Main causes of deaths were obtained from the National registry from @number@ up to @number@
Main challenges that may appear in our country along next decade related with the aging process are discussed.
Main characteristics of cleft palate syndrome and its influence on quality of life are described in the article.
Main damaging mechanisms were related to compression and abrasion leading to tears and holes in the fabric and rupture of stitches.
Main diagnoses , therapeutics interventions , and outcomes : Acute cervical SCI was diagnosed.
Main drinking motives were identified.
Main effects of sex and age were found in many of the same regions showing sex-related differences in aging.
Main effects of SNR were found for both electrophysiology and speech perception measures , while signal level effects were found generally only for speech testing.
Main effects were evident for both walking surface and fall risk for all gait parameters tested.
Main effects were not statistically significant.
Main electroacoustic measures are frequency response , equivalent input noise , total harmonic distortion , and maximum output sound pressure level at @number@ dB.
Main exposure was 4-year time intervals over @number@ decades of observation ; main outcome was mortality from liver disease , HIV , and overdose.
Main focus of research was on adult populations aged @number@ to @number@
Main goal of physiotherapy after that surgery is prevention postoperative complications and reduction of functional limitation.
Mainly moderate to excellent ICC values were found for all tests for the full sample and in all groups ( @number@.59-0.97 ) .
Mainly , mortality differences are explained by differences in functional status.
Mainly oral cobalamin supplementation was used in our study with a significant increase in vitamin B12 levels.
Mainly with secreted growth factors or extracellular matrix proteins , SHEDs contribute to enhanced wound-healing potential of HDFs.
MAIN MEASURES : Changes on untrained , everyday life goals were identified using the Canadian Occupational Performance Measure.
MAIN MEASURES : Conditions and medications associated with testosterone prescription.
MAIN MEASURES : Diabetes mellitus.
MAIN MEASURES : Differences in demographics , hospice diagnoses and length of stay , utilization and costs are presented with descriptive statistics.
MAIN MEASURES : Hazardous , binge drinking , alcohol abuse and alcohol dependence were defined using standard criteria.
MAIN MEASURES : Outcomes measured were readmissions ≤30 days after hospitalizations for pneumonia , heart failure , or acute myocardial infarction.
MAIN MESSAGE : Frailty is common , particularly in elderly persons with complex chronic conditions such as heart failure and chronic obstructive pulmonary disease.
MAIN MESSAGE : One of the most challenging aspects of dementia care is the assessment of driving safety.
MAIN METHODS : Longevity study disclosing the operation of ( TMS ) regulation in rat brain.
MAIN METHODS : Membrane and cytosol were separated by centrifugation and the fluorescence intensity and emission maximum were measured.
MAIN METHODS : The cytotoxicity of curcumin was identified using the 3- ( @number@ , 5-dimethylthiazol-2yl ) -2 , 5-diphenyltetrazolium bromide ( MTT ) assay.
MAIN OBSERVATIONS : In the first two postwar decades increase in life expectancy at age @number@ was concentrated among young people.
MAIN OUTCOME AND MEASURE : Mutation in the neuronal isoform of carnitine palmitoyl-transferase ( CPT1C ) gene.
MAIN OUTCOME AND MEASURES : All-cause mortality data were derived from Australian death records up to @date@ .
MAIN OUTCOME MEASURE : Algorithmically calculated VA.
MAIN OUTCOME MEASURE : Baseline thyroid function was compared according to the development of MCI or dementia during the study period.
MAIN OUTCOME MEASURE : Clinical diagnosis or pathologically confirmed diagnosis of LOAD.
MAIN OUTCOME MEASURE : Electroacoustic results and simulated real-ear measurements.
MAIN OUTCOME MEASURE : Episodic memory scores computed as the mean of the @number@ standardized measures of Logical Memory IA and IIA.
MAIN OUTCOME MEASURE : Erectile quality is the main outcome measure.
MAIN OUTCOME MEASURE : False-positive rates for progression in normal eyes using different definitions.
MAIN OUTCOME MEASURE : Frequency of patient reported alarm symptoms.
MAIN OUTCOME MEASURE : Highly anticholinergic medication use per the @number@ American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults.
MAIN OUTCOME MEASURE : IM prescription at study start , after the 4-month intervention period and at 1-year follow-up.
MAIN OUTCOME MEASURE : Incident cases of all-cause dementia and AD until @date@ .
Main Outcome Measure : Incident CVD.
Main outcome measure : Leukocyte telomere length.
MAIN OUTCOME MEASURE : Medication adherence based on pill-count.
MAIN OUTCOME MEASURE : Medication adherence , hospitalisation and mortality.
MAIN OUTCOME MEASUREMENTS : Demographic data , comorbidities and therapeutical subgroups in patients with a diagnosis of heart failure in their clinical record.
MAIN OUTCOME MEASUREMENTS : Diagnostic yield of conventional endoscopy ; diagnostic yield of VCE versus CT-enteroclysis.
MAIN OUTCOME MEASUREMENTS : Percentages and absolute numbers of CRC deaths prevented and potentially preventable by colonoscopy.
MAIN OUTCOME MEASUREMENTS : Physician-specific ADRs.
MAIN OUTCOME MEASUREMENTS : Subject recall of fall history.
MAIN OUTCOME MEASUREMENTS : The expected numbers of incident colorectal cancers prevented by detection and removal of advanced adenomas.
Main outcome measurements wereunivariate and multivariate analysis between any EUS abnormality and demographic data and habits.
MAIN OUTCOME MEASURE : Predictors of treatment-emergent adverse events ( TEAEs ) identified by multivariate logistic regression analysis.
MAIN OUTCOME MEASURE : Presence or absence of succession planning.
Main outcome measures.
MAIN OUTCOME MEASURES : Activities of daily living and a short version of the Center for Epidemiologic Studies Depression scale were used.
MAIN OUTCOME MEASURES : Activity Measure for Post-Acute Care.
MAIN OUTCOME MEASURES : Age- and gender-standardized prevalence of cataract and @percent@ confidence intervals ( CIs ) .
MAIN OUTCOME MEASURES : All-cause , cardiovascular and cancer mortality.
MAIN OUTCOME MEASURE ( S ) : All-cause , cardiovascular , and cancer-related mortality was measured.
MAIN OUTCOME MEASURES : All-cause mortality and adverse health outcomes.
MAIN OUTCOME MEASURES : All participants were studied yearly for @number@ years.
MAIN OUTCOME MEASURES : All the women completed a neuropsychological test battery.
MAIN OUTCOME MEASURE ( S ) : AMH level.
MAIN OUTCOME MEASURES : Anemia was defined as a blood hemoglobin concentration of < 12.0 g / dL ( @number@ g / L ) .
MAIN OUTCOME MEASURES : A nerve function ancillary study was performed @number@.6±0.4 years after baseline.
Main Outcome Measures : Anthropometrics , insulin resistance , inflammatory markers , habitual diet , physical activity , MyoPS rates , and fiber-type characteristics.
MAIN OUTCOME MEASURES : AT , KL , and LB were compared between the initial plank and maximal roll positions.
MAIN OUTCOME MEASURE ( S ) : Average AMH , AFC , and AMH / AFC were compared between infertile and control women by age.
MAIN OUTCOME MEASURES : Average macular and peripapillary choroidal thickness measured using SD-OCT.
MAIN OUTCOME MEASURES : Balance , gait , and timed Up and Go ( TUG ) test.
MAIN OUTCOME MEASURES : Basic and Advanced Lower Extremity Function as measured by the Late Life Function and Disability Instrument.
MAIN OUTCOME MEASURES : Blood levels of otolin-1 in relation to age.
MAIN OUTCOME MEASURES : BMI.
MAIN OUTCOME MEASURES : BMI.
MAIN OUTCOME MEASURES : Centile charts were compared with previous studies by concurrently plotting the estimates.
MAIN OUTCOME MEASURES : Central corneal thickness.
MAIN OUTCOME MEASURES : Changes in dual-energy X-ray absorptiometry-assessed body composition and lower-limb muscle function were measured.
MAIN OUTCOME MEASURES : Clinical , audiological , and radiological features and management strategies of PDTB.
MAIN OUTCOME MEASURES : Cognition was assessed at baseline and @number@ and @number@ months.
MAIN OUTCOME MEASURES : Cognitive measures included the modified Mini-Mental State Exam and composite scores of memory and language derived from a standardized neuropsychological battery.
MAIN OUTCOME MEASURE ( S ) : Compensatory saccade amplitude and latency , VOR gain , and SPPB performance.
MAIN OUTCOME MEASURES : Concentrations of IGFBP-3 and the IGF-I to IGFBP-3 ratio as determined by the IDS iSYS IGF-I and IGFBP-3 assays were measured.
MAIN OUTCOME MEASURES : Corneal thickness distribution and the difference between assumed and actual PA.
MAIN OUTCOME MEASURE ( S ) : Correlation between age and different percentiles of antral follicle count.
MAIN OUTCOME MEASURES : Correlations between clinical factors and each choroidal structure and ratio of luminal / stromal areas were determined.
MAIN OUTCOME MEASURES : Detection of glaucoma progression and survival probability of macular and RNFL parameters.
MAIN OUTCOME MEASURES : Detection of ITPR1 copy number alterations.
MAIN OUTCOME MEASURE ( S ) : Determination of single-year median and mean AMH values with SDs.
MAIN OUTCOME MEASURES : Difference in energy expenditure ( kcal ) of HSY and SSY.
MAIN OUTCOME MEASURES : Difference in normalized muscle activation between high-speed yoga and standard-speed yoga.
MAIN OUTCOME MEASURES : dyspnea measured on 5-grades scale , mortality measured over @number@ years of follow-up.
MAIN OUTCOME MEASURE : Self-reported fall within the last @number@ months.
MAIN OUTCOME MEASURE : Self-reported incident fractures , which were verified by radiology reports.
MAIN OUTCOME MEASURE : Self-reported medication adherence , clinical biomarkers : BP , lipid profile , glycaemia.
MAIN OUTCOME MEASURES : Endothelial cell density at @number@ years.
MAIN OUTCOME MEASURES : Epiretinal membranes , VMT , macular cysts , PVCs , LMHs , FTMHs , and visual impairment.
MAIN OUTCOME MEASURE : Serum nitric oxide concentrations.
MAIN OUTCOME MEASURE ( S ) : Estimating the relationship between AFC and age and developing the AFC nomogram.
MAIN OUTCOME MEASURES : Five-Times-Sit-to-Stand , TUG , physical activity , quality of life , comorbidities , falls , and body mass index.
MAIN OUTCOME MEASURE ( S ) : Focal Plane Array Fourier transform infrared ( FTIR ) analysis of human oocytes.
MAIN OUTCOME MEASURES : Four domains of cognitive function , testing selective attention , processing speed , and immediate and delayed memory.
MAIN OUTCOME MEASURES : Functional independence , level of disability , and living situation.
MAIN OUTCOME MEASURES : Global neuropsychological performance , cognitive instrumental activities of daily living , and recurrent depression.
MAIN OUTCOME MEASURES : Hedonic and evaluative well-being assessed every two years over the six-year period.
MAIN OUTCOME MEASURES : Hip joint position sense ( JPS ) and kinesthesia were measured using a custom-built device.
MAIN OUTCOME MEASURES : Hospital length of stay.
MAIN OUTCOME MEASURES : Incidence of any type of cataract and of cataract surgery.
MAIN OUTCOME MEASURES : Incidence of CVD.
MAIN OUTCOME MEASURES : Incidence of lens extraction with regard to presence of clinically significant lens opacity and visual function.
MAIN OUTCOME MEASURES : Incident HF , defined as first adjudicated hospitalisation for HF.
MAIN OUTCOME MEASURES : Item performance was evaluated using descriptive statistics and Rasch analyses.
MAIN OUTCOME MEASURE ( S ) : Knowledge , attitudes , and practices regarding selected topics in reproductive health.
MAIN OUTCOME MEASURES : Locally weighted regression was performed to determine the testosterone threshold for Framingham CVD risk and increased hsCRP.
MAIN OUTCOME MEASURES : Longitudinal changes in laminar depth and neuroretinal parameters.
MAIN OUTCOME MEASURES : Lymphatic density , edema , and inflammation.
MAIN OUTCOME MEASURES : MAR equaled the average of the ratio of intakes to Recommended Dietary Allowance for @number@ vitamins and minerals.
MAIN OUTCOME MEASURES : Mean annual hospital bed-days , according to individual step count.
MAIN OUTCOME MEASURES : Mean improvement in Hamilton Scale for Depression scores at T1 and T2 using parameters of sleep and cortisol and melatonin levels.
MAIN OUTCOME MEASURES : Mean lower and upper FDs and FICD for the entire cohort , stratified according to age decade and sex.
MAIN OUTCOME MEASURES : Measures of incident CHD obtained from hospital records , medical history , physical examination , and death certificates.
MAIN OUTCOME MEASURES : Morphologic embryo quality , ploidy and pregnancy rates.
MAIN OUTCOME MEASURES : Motor performance was compared between groups in both studies.
MAIN OUTCOME MEASURES : Muscle strength , balance control , and TUG test performance time.
MAIN OUTCOME MEASURES : Negative mood scores derived from the Affectometer @number@ were assessed at @number@ time points spanning @number@ years.
MAIN OUTCOME MEASURES : Not applicable.
MAIN OUTCOME MEASURES : @number@ adult participants ( age range : 18-81 y ; men / women : 977 / 2465 ) were included.
MAIN OUTCOME MEASURES : Optical coherence tomography-based anatomic definitions and classification of vitreomacular adhesion , vitreomacular traction ( VMT ) , and macular hole.
MAIN OUTCOME MEASURE ( S ) : Optimal fit and age-related AMH nomogram.
MAIN OUTCOME MEASURES : Our study measured percent lean mass , percent fat mass , and lean body mass index.
MAIN OUTCOME MEASURES : Ovarian function was assessed at @number@ yr follow-up in relation to pretreatment hormonal and ultrasound markers of ovarian reserve.
MAIN OUTCOME MEASURES : Participants completed the TUG and UGS at baseline and indicated difficulty in a number of basic ADL and IADL at follow-up.
MAIN OUTCOME MEASURES : Participants were tested twice with the BRU and once with the SMART EquiTest Sensory Organization Test ( SOT ) .
MAIN OUTCOME MEASURES : Participation in activities and QOL.
MAIN OUTCOME MEASURES : Participation restriction was evaluated using the Reintegration to Normal Living Index.
MAIN OUTCOME MEASURES : Patients were asked what bones were affected by PDB , and whether they suffered complications from PDB.
MAIN OUTCOME MEASURES : Performance on the Wechsler Preschool and Primary Scale of Intelligence-Revised , the TEACh-5 , the MABC , and the BRIEF.
MAIN OUTCOME MEASURES : Postal questionnaires were completed by the adults or their proxies ( n = 9 ) .
MAIN OUTCOME MEASURES : Postural response latency , sway variables , trunk motion variables.
MAIN OUTCOME MEASURES : Practices , sexual function , satisfaction , and representations and expectations concerning sexuality.
MAIN OUTCOME MEASURES : Prediction with hazard score of age of onset of aggressive cancer in validation set.
Main Outcome Measure ( s ) - Pre-planned analysis ACR.
MAIN OUTCOME MEASURES : Primary outcome measures include preimplant and postimplant hearing in noise test ( HINT ) and / or AZBio speech perception testing.
Main Outcome Measure ( s ) : Primordial follicle density and the percentage of DNA double-strand break ( DSB ) -positive primordial follicle oocytes.
MAIN OUTCOME MEASURES : Process of occupational therapist goal setting and attainment at the final occupational therapist visit.
MAIN OUTCOME MEASURES : Psychometric quality of DT performance of different DT-tests.
MAIN OUTCOME MEASURES : Pulsatile secretion of free α-subunit ( FAS ) , a marker of GnRH secretion , was assessed.
MAIN OUTCOME MEASURES : Question @number@ of Psychosocial Daily Questionnaire ( PDQ-Q4 ) , the FACIT-Fatigue Scale , and the 6-minute walk test.
MAIN OUTCOME MEASURES : Questions on the ability and degree of difficulty to perform @number@ functions of daily life were asked.
MAIN OUTCOME MEASURE ( S ) : Rate of aneuploidy in endometriosis patients undergoing IVF compared to controls without endometriosis undergoing IVF.
MAIN OUTCOME MEASURE ( S ) : Regular CI use , defined as using the CI for @number@ hours or greater per day.
MAIN OUTCOME MEASURE ( S ) : Relationship between age-related cervical disc herniation and myelopathy.
MAIN OUTCOME MEASURES : Retinal nerve fiber layer thickness.
MAIN OUTCOME MEASURES : Self-rated health and physical activity.
MAIN OUTCOME MEASURES : Self-rated health , physical functioning and depressive symptoms.
MAIN OUTCOME MEASURE ( S ) : Serum AMH levels and correlation between age and different percentiles of AMH.
MAIN OUTCOME MEASURES : Serum AMH was determined by a sensitive immunoassay.
MAIN OUTCOME MEASURES : Six-year incidence of visually significant cataract and associated risk factors data were collected.
MAIN OUTCOME MEASURE ( S ) : Skin wrinkles and rigidity were compared among race / ethnic groups.
MAIN OUTCOME MEASURES : Sleep difficulties.
MAIN OUTCOME MEASURES : Study of angiopoietins-Tie-2 and VEGF-KDR systems in human CC during aging by real-time PCR and WB.
MAIN OUTCOME MEASURES : Survey results were compiled and analyzed by all women and by treatment subgroups.
MAIN OUTCOME MEASURES : The female participants answered a sleep questionnaire , underwent polysomnographic recording and allowed their hormone levels to be measured.
MAIN OUTCOME MEASURES : The Female Sexual Function Index ( FSFI ) was used to assess the key dimensions of female sexual function.
MAIN OUTCOME MEASURE ( S ) : The goodness-of-fit between observed and expected ovarian NGF counts.
Main outcome measures The interviewer used a questionnaire with a checklist of @number@ premenstrual symptoms , sociodemographic and lifestyle variables.
MAIN OUTCOME MEASURES : The main outcome measures included sensitivity of dorsal nerve of the clitoris in RIPB and MRI-pelvis.
MAIN OUTCOME MEASURES : The odds ratio and @percent@ confidence intervals for sexual activity status were calculated separately for men and women.
MAIN OUTCOME MEASURE ( S ) : The percentage of methylation of @number@ CpGs in the CREM promoter was compared between patients and fertile controls.
MAIN OUTCOME MEASURE ( S ) : The percentage of morphologically normal spermatozoa in semen samples.
MAIN OUTCOME MEASURES : The person-time incidence rates of clinically diagnosed RVO in Korea , including the age- and gender-specific incidence rates , were estimated.
MAIN OUTCOME MEASURES : The primary outcome measure was the change score of the Upper Extremity Fugl-Meyer Assessment ( UE-FMA ) .
Main outcome measures : the primary outcome was mental well-being at @number@ months ( mental health ( MH ) dimension of the SF-36 ) .
MAIN OUTCOME MEASURES : The primary outcome was the self report of newly diagnosed COPD.
MAIN OUTCOME MEASURES : The primary study outcome was the motor subscale of the FIM.
MAIN OUTCOME MEASURES : The relative decrease in AMH levels was assessed after a median follow-up of @number@ years.
MAIN OUTCOME MEASURES : The study evaluated the association between TFT results and mortality from all causes and CV diseases.
MAIN OUTCOME MEASURES : Three examiners each used two hand placement techniques ( chin and head ) to elicit the horizontal vHIT responses.
MAIN OUTCOME MEASURES : Time to graft failure ( regraft or cloudy cornea for @number@ consecutive months ) and ECD.
MAIN OUTCOME MEASURES : Time to incident cases of dementia occurring between the 10th and the 20th year of follow-up.
MAIN OUTCOME MEASURES : Time to stabilization of center of pressure ( COP ) after a perturbation on the moving platform.
MAIN OUTCOME MEASURES : To characterize the expression of Tie1 in human CC and elucidate its potential inhibitory effect in Ang-Tie2 system.
MAIN OUTCOME MEASURES : Total number of home hazards.
Main Outcome Measures : Ultrasound was used for diagnosis of NAFLD.
MAIN OUTCOME MEASURE ( S ) : Univariate and partial correlations between ovarian reserve markers and ovarian primordial follicle count.
MAIN OUTCOME MEASURES : We assessed CH , CRF , and their associations with demographic , ocular , and systemic factors.
MAIN OUTCOME MEASURES : We assessed overall mortality , cancer-specific mortality , and the use of salvage hormone therapy.
Main outcome measures were a correlation between the height of the foveal bulge and age of the participants.
Main outcome measures were assessed by Luminex® X-map method on the Bio-Plex® platform.
Main outcome measures were Inventory of Complicated Grief-Revised and the Harvard Trauma Questionnaire.
Main outcome measures were long-term mortality , comorbidity , and HRQoL in old age.
Main outcome measures were self-reported leisure time physical activity and accelerometer-measured physical activity.
MAIN OUTCOME MEASURES : We tested the hypothesis that low sex steroid levels are associated with poor bone microarchitecture in men.
Main Outcome Measure The degree of AWP was scored from @number@ ( no wrinkling ) to @number@ ( severe wrinkling ) by @number@ blinded physicians.
MAIN OUTCOME MEASURE : The main outcome measure was factors correlated with XI.
MAIN OUTCOME MEASURE : The main outcome measure was sexual activity ( defined as intercourse ) during the past year.
MAIN OUTCOME MEASURE : The relationship between serum 25OHD , serum PTH , and serum osteocalcin and 24-h urine N-telopeptides was evaluated.
Main Outcome Measure : This study measured receipt of testosterone and guideline-concordant testosterone prescribing.
MAIN OUTCOME MEASURE : Time to death.
Main outcome measure was proprioception , assessed with an isokinetic dynamometer.
MAIN OUTCOME MEASURE : We measured age at natural menopause.
MAIN OUTCOME : Percentage of weight gain from w0 to w6 ( body mass in kg ) .
MAIN OUTCOMES AND MEASURES : Adjudicated death , incident CVD , and incident HF during @number@ follow-up years.
MAIN OUTCOMES AND MEASURES : Aortic valve calcium quantified by computed tomography in CHARGE and incident aortic stenosis in the MDCS.
Main Outcomes and Measures : At baseline , participants provided information about mentally stimulating activities within @number@ year before enrollment into the study.
Main Outcomes and Measures : Beginning at the age of @number@ years , participants were followed up to the incident disease outcomes.
Main Outcomes and Measures : Blinded casual observer ratings of patients estimated age , attractiveness , perceived success , and perceived overall health.
Main Outcomes and Measures : Brain amyloid accumulation.
Main Outcomes and Measures : Change in health care spending from @number@ through @number@
MAIN OUTCOMES AND MEASURES : Change in the overall cognition compound score.
MAIN OUTCOMES AND MEASURES : Changes in midfacial volume following @number@ treatments of poly-L-lactic acid were measured quantitatively using the 3-D imaging system.
MAIN OUTCOMES AND MEASURES : Clinical characteristics , hospital outcomes , nature of major medical decisions , and surrogate involvement.
MAIN OUTCOMES AND MEASURES : Colorectal cancer.
MAIN OUTCOMES AND MEASURES : Coronary artery calcification greater than or equal to Agatston score of @number@ Hounsfield units ( HU ) at year @number@
MAIN OUTCOMES AND MEASURES Degree of calcification , presence of meaningful calcification , and calcification pattern.
MAIN OUTCOMES AND MEASURES : Depression severity , assessed by the 24-item Hamilton Scale for Depression ( HAM-D ) .
MAIN OUTCOMES AND MEASURES : Development of varying stages of AMD and changes in visual acuity.
Main Outcomes and Measures : Dietary vitamin K1 intake was evaluated using a validated food frequency questionnaire.
Main Outcomes and Measures : Effect of a standard course of fluorouracil on the extent of photodamage as measured using @number@ photonumeric scales.
Main Outcomes and Measures : Estimated mean age and chronological age.
Main Outcomes and Measures : Expression of AQP4 protein , AQP4 immunoreactivity , and perivascular AQP4 localization in the frontal cortex were evaluated.
MAIN OUTCOMES AND MEASURES : Four different PET scans processing pipelines from @number@ different laboratories were compared.
MAIN OUTCOMES AND MEASURES : Fractional anisotropy ( FA ) determined using DTI.
MAIN OUTCOMES AND MEASURES : Frequencies of criminal behavior and χ² statistics were calculated.
Main Outcomes and Measures : Genetic loci identified by conditional false discovery rate analysis.
MAIN OUTCOMES AND MEASURES : Incident CMBs detected on MRIs , which were further categorized as exclusively lobar or as deep.
Main Outcomes and Measures : Incident nontraumatic major osteoporotic fractures ( MOFs ) and hip fractures.
MAIN OUTCOMES AND MEASURES : Information on incident age-related cataract diagnosis and extraction was collected through linkage to registers in the study area.
Main Outcomes and Measures : Injurious falls and fall-related hospitalizations.
Main Outcomes and Measures : In the newborns , cord blood and placental tissue relative telomere length were measured.
Main Outcomes and Measures : Main in vivo and hierarchically organized tau and Aβ deposits in the elderly brain.
Main Outcomes and Measures : Maps of ex vivo magnetic resonance imaging transverse relaxation were generated using fast spin echo imaging.
MAIN OUTCOMES AND MEASURES : Memory , HVa , and amyloid PET.
Main Outcomes and Measures : Mortality and disability , defined as difficulty performing an activity of daily living.
MAIN OUTCOMES AND MEASURES : Neuronal TDP-43 pathological changes and neuronal loss.
MAIN OUTCOMES AND MEASURES : Participants underwent annual evaluation for AD during a follow-up period of up to @number@ years.
MAIN OUTCOMES AND MEASURES : Pathological diagnosis of AD by National Institute on Aging-Reagan criteria following a standard postmortem examination.
MAIN OUTCOMES AND MEASURES : Postoperative outcomes measured included 30-day complications , the need for discharge institutionalization , and 30-day readmission.
MAIN OUTCOMES AND MEASURES : Presence or absence of AMD by fundus photography.
Main Outcomes and Measures : Prevalence of CCM and clinical and radiologic characteristics of study participants with CCM.
MAIN OUTCOMES AND MEASURES : Primary analysis examined the risks for cataract in the propensity score-matched cohort.
Main Outcomes and Measures : Primary outcomes were prescan to postscan changes of diagnosis , diagnostic confidence , and treatment.
Main Outcomes and Measures : Proportion of patients who achieved pCR and disease-free survival after neoadjuvant treatment according to BRCA1 and BRCA2 germline mutation status.
MAIN OUTCOMES AND MEASURES : Rates of postoperative complications and death following nonemergent general surgical operations.
MAIN OUTCOMES AND MEASURES : Regression and analysis of covariance analyses investigated relationships between pulse pressure and distinct cerebral spinal fluid biomarker profiles.
MAIN OUTCOMES AND MEASURES : Risk of hip or major osteoporotic fracture through @number@ or @number@ years following the second BMD measure.
Main Outcomes and Measures : Risk of MCI and dementia ; global and domain-specific cognitive decline.
MAIN OUTCOMES AND MEASURES : Sensitivity and specificity of flutemetamol injection labeled with radioactive fluorine @number@ positron emission tomography imaging for brain β-amyloid.
Main Outcomes and Measures : Sensitivity and specificity of RCM for LM diagnosis.
Main Outcomes and Measures : Spine and hip vBMD was determined by quantitative computed tomography at baseline and @number@ months.
MAIN OUTCOMES AND MEASURES : Statistical association of genetic variants with clinical diagnosis of AD , FTD , and PSP.
Main Outcomes and Measures : The CMIs were graded according to a previously validated protocol.
MAIN OUTCOMES AND MEASURES : The main outcome was the yearly change in composite scores determined from a battery of cognitive function tests from baseline.
Main Outcomes and Measures : The primary outcome was a list of novel loci and their pathways involved in PD and autoimmune diseases.
Main Outcomes and Measures : The primary outcome was noncalcified coronary artery plaque volume , as determined by coronary computed tomographic angiography.
MAIN OUTCOMES AND MEASURES : Unified Parkinson Disease Rating Scale Part III ( UPDRS-III ) and Clinical Dementia Rating scores and neuropsychological performance.
MAIN OUTCOMES AND MEASURES : Use of eye care services ; SEP was measured by the PIR and educational attainment.
MAIN OUTCOMES AND MEASURES We calculated the total and mean lengths of the ROHs per sample.
MAIN OUTCOMES AND MEASURES : We identified @number@ interventional studies.
MAIN OUTCOMES AND MEASURES : We stratified all analyses by race.
MAIN OUTCOMES AND MEASURES β-Amyloid burden , measured by carbon 11-labeled Pittsburgh compound B positron emission tomography distribution volume ratios ( DVRs ) .
MAIN OUTCOMES MEASURES : Ability to rate the BBS in person and using videos with differing bandwidths and frame rates in frontal and lateral views.
MAIN OUTCOMES MEASURES : Baseline plasma concentrations of 25 ( OH ) D and biomarkers of liver and kidney functions and inflammation were measured.
Main outcomes were distance driven per week over @number@ months and community participation.
Main outcomes were gait speed decline ( cm / s / year ) and incident disability.
Main outcomes were total mortality and disability , defined as difficulty with BADL for ≥2 years or institutionalization.
Main participatory behaviors were selective timing , using expressive style , and personalization of the online character.
Main pathological lesions are observed in the spinocerebellar system , as well as in the cerebellar dentate nucleus.
Main PIMs concerned psychotropic and anticholinergic medications.
MAIN RESEARCH VARIABLES : Extent and nature of mobility impairments and concerns raised by patients about barriers to care.
MAIN RESEARCH VARIABLES : Gero-oncology perspective of accessing care across the breast cancer trajectory.
MAIN RESULTS AND THE ROLE OF CHANCE : Of the @number@ women , @number@ ( @percent@ ) used OC.
MAIN RESULTS : A total of @number@ patients were included in this prospective study.
MAIN RESULTS : Of @number@ patients , @number@ patients developed an incident PrU ( @percent@ ) .
MAIN RESULTS : RAA produced a diverse range of effects on the structural integrity and electrochemical properties of electrodes.
MAIN RESULTS : Relevant results informing device design and clinical application were obtained.
MAIN RESULTS : There were a total of four studies that met our inclusion criteria , including a total of @number@ total participants.
MAIN RESULTS : Three trials with @number@ participants met the inclusion criteria.
MAIN RESULTS : Trends of the genuine information transfer with age , already present in literature , were here confirmed.
MAIN RESULTS : We identified eight studies with @number@ eligible participants and an additional @number@ ongoing studies.
MAIN RESULTS : We identified two potentially eligible studies from Russia and the United States.
MAIN RESULTS : We included @number@ studies.
Main sites of interference may be endothelium and gut epithelium.
Maintained activation of brown adipose tissue throughout life may thus protect against obesity and diabetes.
Maintained increase in aerobic exercise was defined as at least 60-minute increase in moderate-to-heavy aerobic exercise per week from baseline to 2- and 4-year assessments.
Maintaining adequate levels of physical activity is known to preserve health status and functional independence as individuals grow older.
Maintaining a healthy population of mitochondria is thus essential for proper cellular homeostasis.
Maintaining a healthy weight could be beneficial in the prevention of sarcopenia.
Maintaining an HLF to prevent DM is especially important for the elderly.
Maintaining an open and supportive community enables older people to maintain sufficient mental activity , which has been shown to reduce MCI.
Maintaining a normal BMI in mid- and late-life may help preserve late-life mobility.
Maintaining a stable and adequate sleeping pattern is associated with good health and disease prevention.
Maintaining both basal and adaptive autophagy against cellular stress may protect the kidney from diabetes-induced cellular stresses.
Maintaining daily function and autonomy may be a suitable target for interventions that aim to reduce the prevalence and incidence of depression in older age.
Maintaining functional protein homeostasis ( proteostasis ) is a constant challenge in the face of limited protein-folding capacity , environmental threats , and aging.
Maintaining genomic integrity is critical to avoid life-threatening disorders , such as premature aging , neurodegeneration and cancer.
Maintaining health and activity of older people is an important indicator of the effectiveness of public policies in the field of health and social welfare.
Maintaining independence and positive tone were perceived as key motivators for fall prevention.
Maintaining its integrity is of fundamental importance for organism's physiology and viability.
Maintaining normal phosphate levels with phosphate binders in patients with CKD with declining Klotho expression is expected to reduce mineral and vascular derangements.
Maintaining optimal nutritional status is therefore crucial for aging in good health.
Maintaining or adopting an active lifestyle alleviates age-related muscle loss to a certain extent.
Maintaining or improving balance confidence is important to avoid unnecessary , self-imposed restrictions of activity and subsequent disability.
Maintaining prior therapy was recommended for @percent@ of treated patients and treatment modification for @percent@.
Maintaining proteome health , or more specifically , \ "proteostasis , \ " is the purview of the \ "proteostasis network. \ "
Maintaining quiescence and avoiding differentiation may be the ultimate challenge to maintain the functions unique for naive T cells.
Maintaining skeletal muscle function throughout the lifespan is a prerequisite for good health and independent living.
Maintaining skin integrity and preventing skin breakdown and moisture lesions in the incontinent patient is an everyday challenge for nurses in the acute setting.
Maintaining the correct folding of cellular proteins is essential for preserving cellular homeostasis.
Maintaining the elderly functionally independent is the first step to achieving active aging and thus improving their quality of life.
Maintaining the health of a human determines longevity.
Maintenance for @number@ month on the deficient diet reduced the performance of both genotypes in both tests , but supplementation with AJC prevented these reductions.
Maintenance of an adequate muscle mass is crucial for the patients ' prognosis irrespective of the underlying condition.
Maintenance of behavior change is reinforced in both groups during months 3-24 through telephone calls and mailed newsletters.
Maintenance of cellular homeostasis influences ageing and it is determined by several factors , including efficient proteolysis of damaged proteins.
Maintenance of circadian rhythms is essential to many aspects of human health , including metabolism and neurological and psychiatric well-being.
Maintenance of cognitive performance was associated with smaller increases in white matter axial diffusivity ( p < @number@ ) .
Maintenance of efficacy with tadalafil was observed across age groups.
Maintenance of good folate status should be emphasized to reduce the risk of cataract in the Taiwanese elderly , especially men.
Maintenance of insulin sensitivity depends on functional mitochondrial networks , but is compromised by alterations in mitochondrial energy metabolism during ageing.
Maintenance of physical activity during aging is of fundamental importance for skeletal muscle to allow it to appropriately respond to the anabolic effects of nutrition.
Maintenance of physical function is a key attribute of successful aging.
Maintenance of telomere length and structure is essential for cell survival.
Maintenance of the mitochondrial genome is a major challenge for cells , particularly as they begin to age.
Maintenance of this function in an aging society is an important issue.
Maintenance of training benefits was also assessed after @number@ months.
Maintenance of training benefits was evaluated at 8-month follow-up.
MAIN TYPES OF DATA COLLECTED : Data collected for participants include social and demographic characteristics , socioeconomic status , life events and behaviours.
Main up-regulated clusters in the anterior horn are related to inflammation and apoptosis ; down-regulated clusters are linked to axoneme structures and protein synthesis.
MAIT cells , their subset , and cytokine levels were measured by flow cytometry.
Major advances in the understanding of neuroplasticity have to date yielded few established interventions.
Major allele homozygotes for MGP rs1800801 and rs4236 had higher plasma ucMGP than heterozygotes or minor allele homozygotes.
Major antibiotic resistance patterns were studied.
Major challenges for future studies are to select the optimal population , set the optimal treatment targets and select clinically relevant outcome parameters.
Major changes can cause anxiety leading to feelings of insecurity and / or loss of self-esteem and depression.
Major changes in cancer diagnosis , treatment , and rehabilitation occurred in the early 2000s.
Major clinical trials and experimental studies showed that aromatase inhibitors are effective against postmenopausal breast cancer.
Major complications occurred in @number@ patient ( @percent@ ) , who had a superior vena cava tear that required thoracotomy.
MAJOR CONCLUSIONS : Functional characterization of S-nitrosylated proteins that regulate neuronal development represents a rapidly emerging field.
MAJOR CONCLUSIONS : The new technique enabled the analysis of isomers of Asp residues in lens proteins precisely and quickly.
Major consequences of multimorbidity are disability and functional decline , poor quality of life , and high health care costs.
Major decline in leisure PA participation starts earlier at ages @number@ to @number@
Major depression affects multiple physiologic systems.
Major depression in the previous @number@ months was assessed with the Composite International Diagnostic Interview ( CIDI ) .
Major depression was diagnosed according to DSM-IV criteria based on a structured interview at baseline and @number@ months.
Major depressive disorder and posttraumatic stress disorder , but not GAD , predicted sedative-hypnotic use.
Major depressive disorder has been associated with activation of inflammatory processes as well as with reductions in innate , adaptive and non-specific immune responses.
Major depressive disorder ( MDD ) and diabetes mellitus ( DM ) have reciprocal relationship and share common pathophysiological mechanisms in the central nervous system.
Major depressive disorder ( MDD ) is a severe psychiatric illness that is associated with significant morbidity and mortality.
Major differences in survival were still observed after adjustment for stage.
Major differences in these indicators are described for older men and women and by age , race , and Hispanic origin.
Major diseases of the elderly that need more attention include chronic non-communicable diseases and mental health disorders.
Major ECG abnormalities were identified in @percent@ of survivors and @percent@ of controls ( P < @number@ ) .
Major economic , political , demographic , social , and operational system factors are prompting evolutionary changes in health care delivery.
Major findings are supported by previous studies.
Major goals of epidemiology are estimation of disease morbidity and mortality and identification and quantification of the impact of risk factors.
Major inputs included ascorbate-mediated oxygen consumption in the vitreous , consumption at the posterior lens surface , and inflow from the retinal vasculature.
Major investments in infrastructure and social services have fostered steady economic growth.
Majority of ARC patients ( @number@ patients ( @number@ % ) ) were managed in non-ICU settings.
Majority of women were ignorant of HRT and took climacteric symptoms as part of aging process.
Majority reads agreed with SUVR classification ( κ @number@ ) .
Major Outcome Measure : Comprehensive cognitive domains were compared between the patient and control groups.
MAJOR OUTCOME MEASURE : The rate of development of MCI or dementia during the study period was compared according to baseline vitamin D status.
Major pathways supposedly involved in the pathogenesis of anorexia are also illustrated.
Major perioperative complications occurred in @number@ patients ( @percent@ ) .
Major progress has been made due to laboratory studies ; in explaining the mechanisms as well as pathophysiological features of brain damage after TBI.
Major progress in the treatment of preterm newborns has changed the pattern of late respiratory complications.
Major questions discussed included the \ "when , where , and how \ " of hematopoietic emergence , bone marrow residence , and disease origination.
Major reasons for satisfaction included the positive aesthetic outcome , a natural appearance , a rested look and comfort of injection.
Major reasons for this are a lack of publications of CANE's German version and the missing validation of the instrument.
Major recent developments in astrocyte biology and the discovery of novel intermediate filament functions enticed the interest in the function of GFAP.
Major repressor proteins that silence γ-globin during development have been targeted for gene therapy in β-hemoglobinopathies patients.
Major research effort in both the United States and Europe has been targeted toward understanding the pathogenesis and epidemiology of dementia.
Major theme ofresiliency and security were identified.
Major themes emerged that focused on rural women's comments regarding their concerns about not worrying or bothering their children with personal health matters.
Make-up can reduce the perceived age , improve the first impression projected and increase the self-esteem of those who apply it.
Making step adjustments is an essential component of walking.
Making transportation and mobility improvements , including environmental modifications , is important for preventing these injuries.
Making use of knowledge of these factors when giving care to older persons may be important in preventing nutritional problems.
Making use of the findings of these studies , this article examines two problems concerning the effect of life extension on population size and welfare.
Making walking possible-or even pleasant-could increase their social participation and use of services.
Maladaptive mPTP- or IMAC-related RIRR may also be playing a role in aging.
Maladaptive stress responses and unhealthy behaviors further explain the association.
Malagasy prediction equations do not exist.
Malaria presents an overwhelming public health challenge , particularly in sub-Saharan Africa where vector favourable conditions and poverty prevail , potentiating the disease burden.
Malaria transmission-blocking vaccines ( TBV ) have been evaluated in field trials in Mali since @number@
Malar prominence average projection increase was @time@ percent and the average amount of lift was @time@ percent.
Malar prominence improved by at least one grade in @number@ percent and by over one grade in @number@ percent.
Malay participants aged 60-80 years from the Epidemiology of Dementia in Singapore Study underwent comprehensive examinations , including 3-Tesla cranial MRI.
Malays and Indians in Singapore valued more of the roles of spouse and children in successful aging , as compared with Chinese.
MALDI-MS can then be used to identify specific metal-containing proteins in these bands or spots.
MALDI-MSI studies correlated the results obtained for decorin.
Male adults preferred more than one rinsing solution in a dental treatment session.
Male age had no effect on rate of pregnancy loss.
Male and female heights at peripubertal ages were significantly greater in @number@
Male and female older persons ' preferences were slightly different for genderized tasks.
Male and female participants were categorized as weak if their normalized grip strength was ≤0.46 and ≤0.30 , respectively.
Male breast cancer ( MBC ) is a rare disease.
Male C57Bl / 6J mice , individually caged , were randomly assigned to one of two groups : sedentary ( inactive ) or spontaneous wheel-runners.
Male caregivers tend toward a managerial approach , whereas female caregivers generally adopt a relational approach.
Male donors in age group of 20-29 years demonstrated beta-endorphin-stimulated and in age group of 50-59 years beta-endorphin-suppressed uptake capacity of neutrophils.
Male face lifting is the cosmetic surgery which has witnessed the greatest rise in demand in recent years.
Male fertility showed a 21-23% annual decrease starting at the age of @number@
Male functioning ( IIEF score ) , depression ( CES-D total score ) , and androgen-deficiency symptoms ( qADAM total score ) improved from baseline.
Male gender and advanced age were significantly associated with an increased risk of MPD dilatation.
Male gender and hypertension were significantly higher in elderly patients.
Male gender , better functional health , and lower body-mass index were independently associated with greater likelihood of walking ( p < @number@ ) .
Male gender , lower education , and presence of ≥1 APOE ε4 alleles were associated with lower average IRT scores.
Male generally had bigger IC and thicker anterior bone.
Male GPs had a significantly higher negative bias score than female GPs.
Male Hispanics smoke at much higher rates than females ( @percent@ vs. @percent@ ) , and one in four smokers in the state is Hispanic.
Male hypogonadism is a clinical syndrome that results from failure to produce physiological concentrations of testosterone , normal amounts of sperm , or both.
Male maxillary bone thickness was greater than female thickness.
Male osteoporosis represents a non-negligible economic burden for the German health care system.
Male participants seen by their friends as more conscientious and open lived longer , whereas friend-rated emotional stability and agreeableness were protective for women.
Male participants showed lower gait symmetry than females.
Male patients reacted faster than female patients , and reaction times tended to slow with age.
Male physicians rarely participated in regular health screenings.
Male primary care physicians had more children than women and others specialists.
Male reproductive success is dependent on insemination success and reproductive output.
Males also reported a higher consumption level.
Males and females showed differential patterns of changing connectivity in large-scale RSNs during normal aging from early adulthood to late middle-age.
Males and females showed different patterns of aging in hair density.
Males and females showed similarly faster thinning rates during adolescence relative to young adults.
Males and females were mostly similar with only three differences found between genders.
Males and patients from the Chinese ethnic group had lower survival rates compared to their counterparts.
Males benefited more ( in QOL ) from social networks and social support , and women from social participation.
Males born before @number@ showed a secular increase in height but females did not.
Male sex and myopia were negatively associated with pterygium recurrence ( each P < @number@ ) .
Male sex , higher educational level , married or partnered status , and more household amenities were inversely associated with frailty prevalence.
Male sex was significantly higher in the OS group ( @percent@ versus @percent@ , p = 0.009 ) .
Males had higher Hcy than females across all ages.
Males had higher serum UA at follow-up compared to baseline ; female change was minimal.
Males had lower adjusted levels of Mn and higher adjusted levels of Se than females.
Males had lower HDL-C at follow-up than at baseline ; females had higher HDL-C at follow-up.
Males had lower mirror-movement ratios than females.
Males have higher oscillation amplitude than females.
Males have more severe disease than females , particularly the oldest.
Males in the youngest age group ( 60-64 ) and of Chinese ethnicity attained greater HGS values than their counterparts.
Male skull bone density remains constant during lifetime , whereas female skull bone density decays slowly from approximately @number@ years onwards.
Males may continue to grow slowly throughout life.
Males ( P < 0.001 ) were at higher risk of urinary retention.
Male spontaneously hypertensive rats and the normotensive Wistar-Kyoto rat strain were divided in 2×3 groups of animals aged @number@ @number@ and @number@ months , respectively.
Males predominantly had the marginal type of calcification , whereas females predominantly had a granular type.
Males showed continuous WM growth from childhood through early adulthood , whereas females mainly showed growth during mid-adolescence.
MALES subjects were obtained from a multinational convenience sample.
Males , the elderly , and neonates were found to be high-risk subpopulations.
Males typically outperform females on spatial tasks , beginning early in life and continuing into adulthood.
Male subjects performed better than female subjects on verbal IQ , performance IQ , and naming tasks.
Male subscapular skinfold thickness : abdominal circumference ratio decreased with advancing age , paralleling the decreases in SBPz.
Males were generally stronger than females in all strength measurements except for IR on the dominant side ( P < @number@ ) .
Males were more affected than females ( @percent@ ) .
Males with insulin resistance ( HOMA-IR≥2.5 ) demonstrated significantly higher AMS scores than those with normal insulin sensitivity ( HOMA-IR < 2.5 ) .
Male to Female ratio was @number@.4 : 1.
Male university students ( N = @number@ ) with body mass index of ≥27 were enrolled.
Male volunteers in the highest tertile of FTI demonstrated greater lateral JPA compared with the lowest tertile ( p < 0.05 ) .
Male were @percent@.
Malignancies and cardiovascular disorders each accounted for approximately @number@ years of life lost.
Malignancy , liver cirrhosis , renal failure , and miliary and pneumonic radiographic patterns were all independent predictors for all TB deaths.
Malignancy was the condition with the shortest survival time ( @number@ years ) .
Malignant effusion had the highest 30-day ( @percent@ ) and 1-year ( @percent@ ) mortality.
Malignant enlargements must be differentiated from benign enlargements for adequate treatment of each patient.
Malignant hematopoiesis , in particular acute myeloid leukemia ( AML ) , results from impaired development or differentiation of HSCs and progenitors.
Malignant melanoma has been thought to be related mainly to exposure to the sun or UV radiation.
Malignant melanoma ( MM ) is a significant cause of morbidity and mortality worldwide.
Malignant mesothelioma is a malignant tumor on the pleura or the peritoneum caused mostly by asbestos.
Malignant neoplasm preferentially occurs in the elderly.
Malignant neoplasms ( C00-C97 ) accounted for @percent@ of @number@ platelet units issued.
Malingering , factitious disorders , and somatoform disorders are discussed due to health-related issues of normal aging.
MALM is involved in the degradation of oxidized mitochondrial proteins , leading to increased ATP synthesis and decreased reactive oxygen species generation.
Malmquist index ( 2010-2012 ) is @number@
MALM was not related to canonical autophagy.
Malnourished , at-risk and well-fed subjects differ significantly ( p < @number@ ) in their mean scores obtained in each of the MNA areas.
Malnutrition affects the inflammatory and the adiposity states ( β : @number@ and β : @number@ respectively ) , while not influencing the sarcopenia.
Malnutrition after hip fracture is common and associated with poor outcomes and protracted recovery.
Malnutrition and drug nutrient interactions are of concern in this population.
Malnutrition and weight loss in dementia correlates with cognitive decline and the progress of the disease.
Malnutrition , a potential result of dysphagia , can also cause sarcopenia.
Malnutrition , as well as HF , is frequently present with aging.
Malnutrition ( both undernutrition and obesity ) plays a key role in the pathogenesis of frailty and sarcopenia.
Malnutrition decreases adiposity ; decreasing adiposity , in turn , increase the sarcopenia and osteoporosis.
Malnutrition diminishes immune function and therefore prevents the host from mounting an adequate protective response to infectious agents.
Malnutrition during old age is a significant public health issue.
Malnutrition is common among older persons , with important consequences increasing frailty and morbidity and reducing health expectancy.
Malnutrition is common in cancer.
Malnutrition is often the cause or consequence and engenders physiological alterations due to decreased food consumption , the ability to eat and access to food.
Malnutrition is strongly associated with dementia occurrence , and is a relevant area for future research within low-income countries.
Malnutrition is the primary cause of immunodeficiency worldwide and profoundly affects immune responses.
Malnutrition rates were higher in individuals living alone.
Malnutrition was associated with reduced mobility ( p < 0.05 ) .
Malnutrition was more common in females , acute admissions , older patients and those who were widowed / separated.
Malnutrition was present in @percent@ of patients with severe cognitive impairment , but only @percent@ of malnourished patients showed moderate cognitive deficit.
Malondialdehyde + 4-hydroxyalkenals level ( LPO index ) was measured spectrophotometrically.
Malondialdehyde ( MDA ) , an oxidative stress biomarker , was also measured in urine samples.
Malondialdehyde ( MDA ) levels were measured as a proxy of lipid peroxidation.
Malondialdehyde ( MDA ) , protein carbonyls ( PC ) level were evaluated to determine the lipid and protein damage in lymphocytes.
MAL-PDT is an effective treatment modality for chronic photodamage , in particular AK and pigmentation.
MAL-PDT is usually conducted with a red light source , ALA-PDT with a blue light source.
Maltreated respondents generally evaluated their maltreating parents less favorably than non-maltreating parents , but there was considerable variation in these recollected relationships.
MA men and women had higher prevalence of obesity compared with NHW.
Mammalian aging can be delayed with genetic , dietary , and pharmacologic approaches.
Mammalian aging has been defined as a reduction in the capacity to adequately maintain tissue homeostasis or to repair tissues after injury.
Mammalian aging of many tissues is associated with a decline in the replicative and functional capacity of somatic stem cells.
Mammalian cells exposed to live pks + bacteria exhibit DNA-double strand breaks ( DSB ) and undergo cell-cycle arrest and death.
Mammalian cells have cytoplasmic and mitochondrial aminoacyl-tRNA synthetases ( ARSs ) that catalyze aminoacylation of tRNAs during protein synthesis.
Mammalian cells produce reactive oxygen and nitrogen species ( ROS / RNOS ) in response to an oxidative environment.
Mammalian microglia are derived from a specific embryonic , self-renewable myeloid cell population that is throughout lifetime not replaced by peripheral myeloid cells.
Mammalian neural stem cells ( NSCs ) are of particular interest because of their role in brain development and function.
Mammalian oocytes are long-lived cells in the human body.
Mammalian reproductive performance declines rapidly with advanced maternal age.
Mammalian sirtuins are located in cytoplasm , nucleus as well as mitochondria.
Mammalian target of rapamycin complex @number@ ( mTORC1 ) and cell senescence are intimately linked to each other and to organismal aging.
Mammalian target of rapamycin ( mTOR ) / S6K1 signalling emerges as a critical regulator of aging.
Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence , which are progressively lost with each round of cell division.
Mammalian TOR ( mTOR ) signaling controls growth , metabolism and energy homeostasis in a cell autonomous manner.
Mammalian wound healing involves the rapid synthesis and deposition of extracellular matrix ( ECM ) to maintain tissue integrity during repair.
Mammary analogue secretory carcinoma ( MASC ) is a recently described salivary gland neoplasm that is defined by ETV6-NTRK3 gene fusion.
Mammary gland neoplasms arose at a greater frequency in C3H / W mice ( P < @number@ ) .
Management and an approach to prevention or early detection of AFF are also provided.
Management based on pathological conditions of gastric ulcers in the elderly persons is required.
Management goals for patients with cognitive impairment are focused on maintaining function and independence , providing caregiver support , and advance care planning.
Management includes screening for the disorder , excluding treatable causes of cognitive decline and cautious use of dopamine agonists and medications such as anticholinergics.
Management of advanced lung cancer in the older patient is a commonly encountered clinical scenario.
Management of bladder and bowel dysfunction in the elderly is currently far from ideal and also carries a significant financial burden.
Management of bleeding peptic ulcers is increasingly challenging in an aging population.
Management of chronic edema using compression is crucial to promote healing of venous leg ulcers.
Management of chronic uremia in elderly patients presents several clinic and organizational difficulties.
Management of elderly schizophrenia patients should thus be targeted towards remission.
Management of impairment includes ensuring that patients are on and adhere to antiretroviral therapy and addressing comorbidities.
Management of injuries in this subset of patients is expanding well beyond sustaining a patient's ability to perform activities of daily living.
Management of OA is primarily focused on palliative relief using agents such as nonsteroidal anti-inflammatory drugs ( NSAID ) and analgesics.
Management of steroid-related adverse events will increase costs further , with steroid-induced fractures estimated to total US $ 6 billion by @number@
Management of symptoms of PD in older patients is challenging because of possible existence of several age-related systemic illness.
Management of the surgically unfit patient with symptomatic cholelithiasis can be fraught with difficulty.
Management of this elevated risk for developing multimorbidity is a major concern for patients and their health care teams.
Management of vascular risk factors remains a proven and practical approach to reducing acute and progressive cognitive impairment and dementia.
Management options range from lifestyle assessment and intervention through to hormonal and non-hormonal pharmacotherapy , each of which has specific benefits and risks.
Management practices were diverse and rarely involved accessing health professionals.
Management should be tailored according to the underlying dermatological or systemic aetiology of itch.
Management strategies include surveillance , ablation , and extirpation.
Managers and administrators seeking to implement person-directed care will need to consider the role of adaptive leadership to address these adaptive challenges.
Managing ageing has led to consideration of a number of policies where it is essential to increase the employment rate for older workers.
Managing diabetes in this population is challenging , because complex comorbidity and disability often mean that guidelines are not suitable on an individual basis.
Managing elderly patients receiving anticoagulants is challenging because those patients are at high risk of both thrombosis and bleeding.
Managing MetS , as well as its components , may contribute to control cognitive decline and reduce related disease and social burden.
Managing modifiable risk factors ( e.g. , hyperlipidemia , hypertension ) remains the primary approach to prevent ASCVD events and ASCVD-related mortality.
Managing neuropsychiatric symptoms is challenging and requires a team approach in which nonpharmacological strategies are preferred before medications are considered.
Managing OAB symptoms in this population is a great challenge.
Managing TB as well as underlying comorbidities in a multidisciplinary approach is essential to improve the outcome of patients in an aging population.
MANCOVA was used for comparisons by age and year.
Mandatory folate fortification areas will be important future field studies for-like neural tube defects-hopefully declining AD incidence and disproving safety concerns.
Mandibular cortical width can be determined automatically from dental panoramic radiographs that dentists frequently request , using appropriate software.
Mandibular length and height both decreased significantly for each sex.
Mandibuloacral dysplasia type A ( MADA ) is a rare disease caused by mutations in the LMNA gene encoding A type lamins.
Manganese ( Mn ) is one of the most studied environmental heavy metals linked to Alzheimer's disease ( AD ) .
Manganese superoxide dismutase ( Mn-SOD , SOD2 ) is a mitochondrial antioxidant enzyme that converts toxic superoxide to hydrogen peroxide.
Manipulation of apoptosis has emerged as a new therapeutic strategy to eliminate cancer cells.
Manipulation of HSP70 expression results in disposal of misfolded protein aggregates that accumulate in aging and disease models.
Manipulation of retinal zinc metabolism in these situations might improve visual function.
Manipulation of SirT1 levels in young cells confirmed the role of SirT1 in cellular migration and proliferation capability.
Manipulation of the microbiota and microbiome of older adults holds promise as an innovative strategy to influence the development of comorbidities associated with aging.
Manipulation of these pathways provides an attractive therapeutic option for glomerular diseases.
Manipulation of these principles enables production of highly enriched neural types with functional attributes that resemble those in the brain.
Mannitol showed promising results in small retrospective series and might be a valid treatment modality ( type C recommendation ) .
Mannoprotein content and the aromatic profile were determined and a sensorial analysis of the wines was conducted.
Mannose binding lectin ( MBL ) plays important role in the innate immunity of human.
Mannose residue binds to POMK mainly via the hydroxyl group at C2-position , differentiating from other monosaccharide residues.
Mann-Whitney U analysis showed no difference between dose : [ Px ] among patients with LVEF of less than @percent@ versus @percent@ or greater.
Mann-Whitney U and Kruskal-Wallis tests were used to compare values between the healthy controls and the AMD group and also between the subgroups under study.
Mann-Whitney U tests or Student t-tests were used for between-group comparisons and the Spearman correlation coefficient was used for correlation analyses.
Mann-Whitney U tests were used to compare the differences between the intervention and control groups.
Mann-Whitney U test was used to compare retinol and zinc values.
Manometric diagnoses were generally similar across the three groups.
Manor was surprised.
MANOVAs were used to compare the data.
Mantle cell lymphoma is a distinct subtype of B-cell non-Hodgkin lymphoma , accounting for 3-10 % of all non-Hodgkin lymphoma cases.
Mantle cell lymphoma is a relatively rare B-cell lymphoma with a specific genetic lesion and a typical immunophenotypic profile.
Manual dexterity was also improved in the presence of caffeine ( P = @number@ ) .
Manual examination of the RIPB also elicited the genital sensations at the left side of the vagina at about the @number@ o'clock position.
Manual for the Positive and Negative Affect Schedule Expanded Form.
Manually segmenting WMHs in large cohorts is technically unfeasible due to time and accuracy concerns.
Manual muscle testing and computed tomography scan assessment of lean tissue are other tools that show promise in correlating functional and nutrition assessments.
Manual muscle test was used for checking strength of hip flexor muscles , hip abductor muscles and knee extensor muscles.
Manual permeabilization is an advantageous technique for preparing human skeletal muscle biopsies for respirometry.
Manual segmentation approaches result in higher measured atrophy rates.
Manual segmentation remains the reference method.
Manual tracing is still the criterion standard but is time-consuming.
Manual tracing of hippocampal and amygdalar volumes and visual rating of white matter lesions were made.
Manual volumetric analysis was assessed in patients more than @number@ years of age.
Manufacturers and professional associations were contacted in order to identify further non-published studies.
Manufacturing models were less explanatory.
Manufacturing processes have specific standard times that might be inappropriate if they are performed by individuals who do not meet the standard energy production capacity.
Manuscripts provided information on @number@ instruments which were evaluated using a structured scoring guide for psychometric properties.
Many A and P goals seem underrepresented at the intake procedure , for example : communication , peer interaction and participating in leisure activities.
Many activities of daily living require moving both hands in an organized manner in space and time.
Many acute and chronic lung diseases could benefit from improved regeneration therapy.
Many aged people suffers from cataract because prevalence of cataract in advanced age is far higher than younger people.
Many ageing-associated dysfunctions in stem cells have been described , but it remains ambiguous whether these are merely an outcome of ageing or are causal.
Many aging theories and their related molecular mechanisms have been proposed.
Many agonists showed only ( weak ) partial agonism regarding βarr recruitment.
Many ALS / FTD linked genes play a direct role in autophagy / lysosomal degradation , one of the most important pathways linked to ageing.
Many also report that has been reduced due to the spread of osteoporosis treatment in the world.
Many alternative approaches exist which allow planners to relax the assumption of a fixed relationship between age and health.
Many antitumor mechanisms protect potential malignant transformation of stem cell by inducing apoptosis or senescence but simultaneously provoke stem cell aging.
Many are known to affect multiple cellular functions.
Many arguments suggest that these diseases are associated with premature senescence of lung cells , which may be involved in the pathophysiology of respiratory alterations.
Many authors have evaluated these techniques and the results are discussed here.
Many authors reported about the kinematics of a normal squatting motion , however , little is known on what the influence of aging is.
Many avenues have been explored but no global picture or clear evidence has emerged.
Many behavioral changes and public policy responses to aging of the population have been implemented to cope with these challenges.
Many biodemographic studies use biomarkers of inflammation to understand or predict chronic disease and aging.
Many biological aspects concerning dose , time and site of administration are still to be elucidated.
Many candidate genetic polymorphisms have been examined in a large number of studies.
Many causes of premature aging have been discussed in order to prevent it or find suitable medical treatment.
Many cell types may be activated-specifically , endothelial , tubular and mesangial cells , and podocytes.
Many cellular processes are driven by spatially and temporally regulated redox-dependent signaling events.
Many children experience pre-school or early childhood wheezing.
Many clinical and animal studies demonstrate the importance of long-chain polyunsaturated fatty acids ( LCPUFA ) in neural development and neurodegeneration.
Many clinical features of lung cancer are different in women and men.
Many cognitively intact individuals were classifiable as pAD ( 53 / 126 or @percent@ ) , as expected based on epidemiological and biomarker studies.
Many common and a few rare genetic factors are associated with AMD.
Many community resources are available to help older adults begin a more active lifestyle.
Many comparative genomics studies aim to find the genetic basis of species-specific phenotypic traits.
Many consensus reports have been published regarding correct treatment with botulinum toxin A ( BTX-A ) .
Many consortia and international projects have investigated the human genetic variation of a large number of ethno-geographic groups.
Many consumers view AL communities as a viable option to receive needed services and age in place.
Many cosmetic products and procedures provide global improvement to aging skin , whereas injectable therapies are frequently utilized to diminish specific , target wrinkles.
Many countries are facing social and economic problems due to increased elderly demographics.
Many countries have an aging middle-aged donor and population cohort and are increasingly relying on their youngest donors to contribute disproportionately to the blood supply.
Many countries , including the USA , publish predicted numbers of cancer incidence and death in current and future years for the whole country.
Many countries in Europe and the world have to cope with an aging population.
Many countries that have public health insurance system like Japan have introduced Health Technology Assessment ( HTA ) for pricing and reimbursement decision.
Many CpG sites show significant tissue-independent correlations with age which allowed us to develop a multi-tissue predictor of age in the mouse.
Many cross-sectional studies have investigated the relationship between neighborhood physical environment and physical activity.
Many cross-sectional studies have tried to assess the in vivo effect of oxidative stress on organismal aging in general and on telomere length dynamics specifically.
Many cross-sectional studies of neighbourhood effects on health do not employ strong study design elements.
Many cross-sectional studies reported that air pollution caused respiratory disease in Japanese individuals in the 1960s.
Many daily activities require appropriate allocation of attention between postural and cognitive tasks ( i.e. dual-tasking ) to be carried out effectively.
Many definitions of fatigue involve a sensation of \ "low \ " energy , suggesting that fatigue could be a disorder of energy balance.
Many definitions of successful ageing have been proposed , but at present there is no consensus definition.
Many degenerative disease processes associated with aging result from enhanced extracellular matrix ( ECM ) breakdown.
Many described having to intervene in the patient's care to stop unnecessary or harmful screening , and others met resistance when they advocated for stopping.
Many detected genetic loci harbor variants that associate with multiple-even distinct-traits.
Many different compounds from many different pharmacological classes have already been studied in an AD context.
Many different speed-up techniques for CS-based reconstruction algorithms have been developed.
Many difficulties arise in identifying good biomarkers.
Many diseases in the elderly are more frequent and more severe in comparison to the younger population.
Many diseases like atherosclerosis or heart failure are involved in oxidative stress.
Many disorders present as non-specific signs or symptoms in the elderly.
Many distinct brain diseases other than AD afflict older human brains and contribute to cognitive impairment.
Many domains are relevant , including health , longevity , social adjustment , marital relationships , and the experience of major life events.
Many drugs for the treatment of osteoporosis have also been associated with increased risks of serious adverse events.
Many elderly have mild physical disorders.
Many elderly people are affected by cardiovascular diseases ( CVD ) and the majority of CVD patients are elderly people.
Many environmental agents affect the development of male germ cells at different stages.
Many environmental factors are now known to cause epigenetic changes , including the presence of pathogens , parasites , harmful chemicals and other stress factors.
Many epidemiological and clinical studies use accelerometry to objectively measure physical activity using the activity counts , vector magnitude , or number of steps.
Many epidemiological studies have shown that parents , siblings and offspring of long-lived subjects have a significant survival advantage when compared with the general population.
Many experimental in vivo studies have indicated that Schwann cells are key facilitators of peripheral nerve regeneration but their clinical therapeutic potential may be limited.
Many facial plastic surgeons who are experienced in operating only in the head and neck region are unaccustomed to working elsewhere in the body.
Many factors are responsible for the inconsistent / negative results of some studies.
Many factors causing ocular surface damage and inflammation have been shown to contribute to the etiopathogenesis.
Many factors contribute to the etiology of depression and dementia , being inflammation one of those.
Many factors contribute to weight loss and malnutrition in older adults.
Many factors , including the age-related hormonal dysregulation , may concur to the development of disability in the elderly.
Many factors or phenomena are known to contribute to proceed sarcopenia.
Many factors that increase the risk of developing overactive bladder are modifiable ; therefore , lifestyle and behavioral interventions are first-line treatments.
Many falls in older adults occur during walking following trips.
Many families considering posthospital care options are ill-prepared and in need of guidance.
Many forensic STR kits are currently available in the market.
Many frail older adults are thin , weak , and undernourished ; this component of frailty remains a critical concern in the geriatric field.
Many genes have been found to be pathogenic for amyotrophic lateral sclerosis ( ALS ) .
Many genetic and environmental factors influence the fracture risk.
Many genetic factors have been implicated in OA.
Many genetic forms of cataract have been described in mice and other animal models.
Many genotoxic chemotherapies target proliferating cells nonspecifically , often with adverse reactions.
Many GI disorders are difficult to diagnose and their symptoms are not effectively managed.
Many GWAS have identified trait-associated SNPs that felt in noncoding genomic regions.
Many healthcare systems have developed case management programs in order to optimize dementia patients and caregivers care and services delivery.
Many health-related outcomes follow a pattern that is similar to physical activity participation.
Many histiocytes , some of which contained hemosiderin pigments , and variously shaped mucinous material were evident in the background or within the epithelial clusters.
Many human diseases are characterized by the development of tissue hypoxia.
Many imaging-based degenerative features are likely part of normal aging and unassociated with pain.
Many important biological roles of glycoproteins are modulated by N-linked oligosaccharides.
Many indigenous cultures use storytelling as the foundation for the transmission of important cultural information.
Many individuals with dementia also receive acetylcholinesterase inhibitors ( AChEIs ) , indicated for mild to moderate Alzheimer's disease.
Many ineffective measures have been implemented , such as tarification according to activity , and hospital certification.
Many interventions ( n = @number@ ) had weaker evidence of benefit ( Grade C ) .
Many in vitro studies have linked MTL and radiosensitivity.
Many issues remain to be clarified in the pathogenicity of RAGE.
Many lesbian and gay seniors experience health disparities and are at risk for poor health outcomes.
Many life-extending manipulations in rodents , such as caloric restriction , also decrease core body temperature.
Many longitudinal studies have found that older adults with depressive symptoms or depression have increased risk of cognitive impairment.
Many markers of inflammation are elevated in HIV disease and strongly predictive of the risk of morbidity and mortality.
Many measures can be adopted to prevent serious complications in the elderly.
Many mechanisms of sarcopenia development have been reported.
Many methods have since extended this approach to various situations.
Many microRNAs modulated by aging were identified , including miR-30a , in which both strands were overexpressed in aged cells and epidermal tissue.
Many miRNAs are highly expressed in the vasculature , and their expression is dysregulated in diseased vessels.
Many misconceptions surround the role of dietary protein in the management of diabetes.
Many modalities for treatment of DDD have been developed including therapeutic protein injections , stem cell injections , gene therapy , and tissue engineering.
Many models of human tauopathies have been generated in mice by expression of a human mutant tau with maintained expression of mouse endogenous tau.
Many molecular lesions have been detected in Alzheimer's disease , but physiopathology is still poorly understood.
Many molecules are now known to be actively associated with this process.
Many natural and synthetic quinones and naphthoquinones possess a variety of beneficial pharmacological properties.
Many neurodegenerative disorders involve the abnormal accumulation of proteins.
Many newly diagnosed prostate cancers present as low Gleason score tumors that require no treatment intervention.
Many new technologies are introduced to our medical practice with the promise of being the ideal office-based procedure.
Many non-pharmacological and pharmacological interventions are available for managing COPD.
Many nonsurgical therapies exist to tackle these problems.
Many nonvisual functions are regulated by light through a photoreceptive system involving melanopsin-expressing retinal ganglion cells that are maximally sensitive to blue light.
Many NRF2-mediated antioxidant phytochemicals are capable of up- and downmodulating AHR signaling.
Many nursing home transition barriers are manmade and avoidable.
Many obese subjects complain of dyspnea either at rest or during exertion , and the dyspnea score also correlates with reductions in FRC and ERV.
Many of such nonexponentially degraded ( NED ) proteins are components of macromolecular complexes.
Many of the adverse effects of GCs on skin are also reminiscent of the natural aging process.
Many of the changes can be visualized using MRI.
Many of the changes observed with increasing heel height and weight were similar to those seen with aging and OA progression.
Many of the complications of hemophilia , including intracranial hemorrhage , joint disease , and inhibitor development , increase with increasing age.
Many of the conditions associated with early-life nutrition are also those which have an age-associated aetiology.
Many of the diagnoses made are treatable , and when treated , the outcome improves.
Many of the differences amplified in protein data were reflective of cytoarchitectural and functional variation between brain regions.
Many of the examples presented are also known to cause human disorders.
Many of the gastrointestinal disorders seen in specialist practise show age-specific incidence and prevalence rates that increase substantially with increasing age.
Many of the ideas contained herein have been initially presented within or derived from her work ( Hernandez , M.R. , @number@
Many of them have distinct postnatal expression patterns and are regulated by Rhox5 at different postnatal time points.
Many of them show a significant decrease with age.
Many of the newer technologies , such as devices that integrate a fractional delivery system , provide excellent results with few adverse side effects.
Many of the pathologies associated with the aging process also contribute to tumor initiation , growth or metastasis.
Many of the proteins that regulate autophagy are either oncogenes or tumor suppressor proteins.
Many of the responses to oxidative stress involve a specialized class of enzymes known as helicases , the topic of this review.
Many of these advantageous cellular adaptations are promoted by the pathophysiological hypoxia that arises in solid tumours due to incomplete vascularisation.
Many of these alterations also occur in patients with or at risk for AF , although the direct demonstration of these mechanisms is sometimes challenging.
Many of these alterations in hormone production and signaling are directly influenced by an increase in both oxidative stress and inflammation.
Many of these are amenable to lifestyle modification.
Many of these clusters are associated in GWAS with multiple phenotypes.
Many of these compounds are drugs approved for human use.
Many of these compounds have other potential beneficial effects on lifespan as antiatherogenic or antineoplastic agents.
Many of these diseases are characterized by the accumulation of misfolded proteins in intra- and extracellular inclusions , such as amyloid plaques.
Many of these episodes are not from a urinary source , so critical clinical evaluation is always necessary.
Many of these functions are altered in older adults , promoting a prothrombotic , proinflammatory milieu and contributing to risk of adverse clinical events.
Many of these functions not only relate to the current state of the local neural environment but also depend on previous experience.
Many of these individuals will require medical and surgical interventions for gender dysphoria.
Many of these ingredients found in nature possess potent antioxidant as well as anti-inflammatory properties.
Many of these pathways are driven by chronic exogenous and endogenous oxidative stress.
Many of these pathways are driven by chronic oxidative stress.
Many of these patients undergo coronary angioplasty or bypass graft surgery ( CABG ) .
Many of these patients will be diagnosed at an early stage.
Many of these patients will have several chronic diseases , including those related to vision loss.
Many of these procedures use absorbable and nonabsorbable sutures in the dermis and subcutis to lift lax skin.
Many of these strategies have focused on the effective management of pulmonary disease which has delayed its manifestations into later years.
Many of these substances have been shown to lengthen the lifespan of invertebrates.
Many of these translation control factors can be mapped to a single pathway downstream of the nutrient responsive target of rapamycin ( TOR ) kinase.
Many of the survey-based and the actigraph-estimated sleep parameters varied by age and gender.
Many of the top genes are involved in inflammation-related pathways or erythrocyte function , including JAK / Stat signaling pathway and interleukin-10 signaling pathway.
Many of the well-known miRNAs relate to crucial genes that can impact metabolic pathways , both negatively and positively.
Many of those who arrived early are now aging rapidly and are depleting their financial resources.
Many older adults , aware of such cognitive changes , seek ways to bolster their cognitive functioning.
Many older adults do not meet physical activity recommendations and suffer from health-related complications.
Many older adults ( seniors ) experience problems with getting enough sleep.
Many older adults with schizophrenia successfully adapt to the illness , with increased use of positive coping techniques , enhanced self-esteem and increased social support.
Many older listeners report difficulties in understanding speech in noisy situations.
Many older patients with HFs are malnourished or at risk of malnutrition.
Many older pedestrians report inability to complete crossings in the time given by pedestrian lights.
Many older people in the UK are at risk of developing and dying from heat-related illnesses during a heatwave.
Many older people who access these services have frailty , which is a state of vulnerability to adverse outcomes.
Many older persons have become critical of the reforms over time.
Many oncology team members , highly skilled in clinical care , are not trained to work effectively as members of a care team.
Many other factors result in secondary osteoporosis , including treatment for other diseases such as cancer and diabetes.
Many other intervention strategies are in various stages of development.
Many ovarian tumors are associated with abnormal hormonal activity and / or abnormal sexual development.
Many patients cited affordability as an obstacle and considered self-treatment options including alcohol intake for depression control.
Many patients classified as severely uncontrolled based on HbA1c received only monotherapy.
Many patients described psychological / mental and financial anxiety because of the aged profile of sIBM patients.
Many patients present to regional hospitals and are transferred to tertiary care centres for surgical management , resulting in long delays to surgery.
Many patients were physically inactive ( @percent@ ) .
Many patients with various diseases develop taste disorders , including taste loss and taste distortion.
Many people accept the idea that time seems to pass more quickly as they get older , as if this is a psychological reality.
Many people living with human immunodeficiency virus ( HIV ) do not know that they are infected.
Many people with cervical spondylosis or CSM are asymptomatic.
Many people with chronic medical conditions or who are immunocompromised due to disease or aging are also under-vaccinated.
Many people with dementia are likely to have other health problems , which need to be considered in concert to achieve optimal health outcomes.
Many persons misidentify the quality of taste stimuli , a phenomenon termed \ "taste confusion. \ "
Many physical activity interventions are of short duration and do not report long-term changes in clinical measures or adoption of prescribed health behaviors.
Many physiological and pathological conditions are associated with a change in the crystalline lens transmittance.
Many physiologic and nonphysiologic factors contribute to performing correct or incorrect nerve conduction studies.
Many plants have been proven to possess efficacy on sexual dysfunction and osteoporosis in traditional Chinese medicine ( TCM ) .
Many possible mechanisms underlying the relative selective vulnerability of neurons are being explored.
Many preclinical studies indicate that steroid hormones modulate the age-dependent differential stroke outcome.
Many professionals do not appear to enquire routinely about non-prescribed medicinal products and adequate advice may not be given to patients / carers.
Many proteins are known modulators of retrograde signaling , but whether microRNAs ( miRNAs ) are also involved is unknown.
Many publications include multiple analyses , like different cut-off values for ' old' , or taking into account both oldest and average RBC storage time.
Many public use social science datasets have or will soon add genome-wide genetic data.
Many PWH above this age thus have limitations in their activities of daily life.
Many recent epidemiological studies link metabolic acidosis indicators with insulin resistance and systemic hypertension.
Many recent experimental results indicate that the post-mitotic neurons are particularly prone to accumulation of unrepaired DNA lesions potentially leading to progressive neurodegeneration.
Many reforms are based on over-optimistic economic predictions that fail to take related overheads into account.
Many reports have shown that the disorder of MSC adipogenic and osteogenic differentiation occurs in some diseases.
Many researchers have designed and developed orthoses for walking assistance.
Many research , notably that of Gene Cohen ( @number@ ) , have shown positive impact of artistic activities for seniors.
Many research teams are dealing with the mechanisms of the neurodegeneration.
Many RIP substrates are localized to the synapse and thus could convey a direct signal from the synapse to the nucleus upon cleavage.
Many scales quantify similar constructs.
Many scientists claim that oxidative stress causes many pathological conditions.
Many scored poorly for scope , vocabulary , aspects of layout and typography , and learning stimulation and motivation.
Many senescence-inducing stressors are potentially oncogenic , strengthening the notion that senescence evolved alongside apoptosis to suppress tumorigenesis.
Many sensory and cognitive changes accompany normal ageing , including changes to visual attention.
Many SMs have S / R beliefs that could increase vulnerability to MI.
Many specialized positions are emerging for nurses in care coordination.
Many standardized measures of cognition include items that must be seen or heard.
Many statin users experience muscle pain , but the mechanisms are unknown at the moment.
Many stroke patients , upon discharge , went to another short-stay hospital or a long-term care institution.
Many studies are being undertaken to find novel compounds which can improve a typical human life span and aid in healthy aging.
Many studies demonstrated that the neurovascular unit is compromised in cerebrovascular diseases and also in other types of dementia.
Many studies depicted the involvement of mitochondrial dysfunction and oxidative damage in aging and pathogenesis of age-related metabolic disorders and neurodegenerative diseases.
Many studies describe conditional reasoning , focusing on intra-individual and general processes.
Many studies have demonstrated that exposure to excess fluoride was associated with a variety of diseases.
Many studies have demonstrated that fat longevity is dependent upon handling and preparation of fat.
Many studies have hypothesized that mitochondrial function could be involved in these side effects.
Many studies have investigated how microglia modulate alcohol-induced behavioral changes such as cognitive deficits , abnormal locomotor activity , motor impairment and mood disturbance.
Many studies have observed altered neurofunctional and structural organization in the aging brain.
Many studies have provided evidence that IL-3 plays an important role in cell survival.
Many studies have reported DNA methylation-based age predictive models , but most of these are based on DNA methylation patterns from blood.
Many studies have reviewed the corticospinal tract ; however , review articles from the rehabilitative viewpoint are lacking.
Many studies have shown a strong correlation between serum cholesterol levels and risk of developing CAD.
Many studies have shown that our organism is mostly sensitive to different influences in pre- and postnatal periods of ontogenesis.
Many studies have shown that providing a spatial retrospective cue ( \ "retrocue \ " ) improves VSTM capacity estimates for healthy young adults.
Many studies have shown that variations in cytokine genes might play a role in determining human longevity.
Many studies indicate essential nature of food in maintaining health.
Many studies noted that T deficiency might contribute to increased risk of CVD.
Many studies on electromagnetic fields - in particular cellular phones - pesticides , solvents , and other factors have been published.
Many studies on long-lived people have been conducted emphasizing the role of certain genes in long life.
Many studies reported that certain features of BP like nocturnal hypertension , morning surge or increased variability predict an increased stroke risk.
Many studies used event-related potentials ( ERPs ) elicited by sound onsets to characterize the age-related differences in central auditory processing.
Many study have investigated the association between telomeres length and PTSD , but results from published studies are contradictory.
Many surgeons also reported time for administration , teaching , and research.
Many surgeons have modified their approaches to managing the aging changes of the upper eyelids.
Many surgical options exist to address these deformities.
Many survivors of severe disasters , even those without posttraumatic stress disorder ( PTSD ) , need psychological support.
Many survivors of severe disasters need psychological support , even those not suffering post-traumatic stress disorder ( PTSD ) .
Many systems essential to ontogenesis become inappropriate in later life , leading to the ageing of cells and loss of regenerative capacity.
Many TDP-43-positive cytoplasmic inclusions were also observed in the dentate gyrus of the hippocampus.
Many techniques and theories lie behind the treatment of such injuries.
Many techniques for addressing and correcting aesthetic defects associated with pachydermoperiostosis have been introduced , including facelift surgery.
Many techniques have been presented over recent decades to address the neck contour in facial cosmetic surgery.
Many techniques have been reported for rejuvenation of the upper eyelids.
Many theoretical accounts predict that as people age , they rely increasingly on affect.
Many theories of cognitive aging are based on evidence that dopamine ( DA ) declines with age.
Many therapies based on the manipulation of growth factors and hormones have succeeded in partially recovering the lymphoid compartment and promoting thymic function.
Many thousands of Circular RNAs ( circRNAs ) have recently been identified in metazoan genomes by transcriptome-wide sequencing.
Many topics that are now current are things Békésy could not have imagined.
Many traits of aging are related to oxidative damage by ROS , including neurodegenerative diseases.
Many treatments have been described for this area , including fat injections and implants.
Many treatments have been proposed.
Many treatments have been reported , but are poorly effective.
Many tumors do not respond to drug treatment due to their resistance to undergo apoptosis thereby contributing to the development of cancer.
Many unanswered questions on medical , psychosocial and health economic consequences remain as the needs of older patients have not yet been evaluated extensively.
Many variables , such as genes , medications , depression , and environmental factors , influence sleep in persons with Alzheimer's disease.
Many variations had not vanished at the recovery phase.
Many websites are promoting oral DHEA as an anti-aging tonic and in some countries it is sold as a supplement.
Many were former prisoners of war , with most remaining psychologically resilient and free of any psychiatric diagnoses.
Many were prescribed dementia medications and / or other psychotropic medications , predominantly antidepressants.
Many were primarily Chinese speaking with low levels of education.
Many women believe their symptoms are expected signs of aging.
Many women now choose to develop their careers before having children.
Many women ( @percent@ ) were not aware of VVA or that it is a medical condition.
Many women were dissatisfied with the care they had received.
Many would argue for taking a precautionary approach and immediately banning or restricting sports such as boxing.
Many xenobiotics , if inadequately metabolized by xenobiotic metabolizing enzymes and not wholly eliminated , could have deleterious toxic effects with potentially lethal consequences.
MAOA-uVNTR did not associate with either AD or DE.
MAO-A was increased significantly ( ca.
MAO decreased gradually with age in males , whereas it remained unchanged with age in females.
MAP and MSNA responses to a cold pressor test were not different between groups , suggesting no group differences in generalized sympathetic responsiveness.
MAPD members between @number@ and @number@ years old identified as having T2DM between @number@ and @number@ were eligible for inclusion.
MAP increased with the onset of handgrip ; this increase was associated with handgrip intensity and was similar in both groups.
MAPK1 and PRKCB levels were low in the brainstem and cerebellum.
Mapping from M1 may offer foundation for an examination of mechanisms that preserve strength in elderly.
Mapping of the location of aging people and identification of their needs can be extremely valuable from a social-economic point of view.
Map size , volume , and response density showed no significant difference between groups.
Maps were assembled from @number@ cells in @number@ locations.
March births exceeded the monthly average by more than two standard deviations ( SD ) - @number@ with an analogical increase for both genders.
Marf mutants also fail to maintain proper synaptic transmission at NMJs upon repetitive stimulation , similar to Drp1 fission mutants.
Marginal adaptation of the restorations was evaluated in a SEM ( ×200 ) using a replica technique.
Marginal adaptation of zirconia-based FDPs is acceptable for clinical application.
Marginal adaptation was evaluated in terms of \ "continuous margin \ " at the gingival margin , using a low vacuum scanning electron microscope.
Marginal balance improvements were found only in HE in the medial-lateral direction.
Marginal donors have been accepted as organ donors in recent years.
Marginally increased head-roll velocity in the older participants possibly suggests decreased integrative ability of the central nervous system in elderly people.
\ "Marginal opening \ " was observed between @percent@ to @percent@ in enamel and @percent@ to @percent@ in dentin.
Marginal structural models were used to assess impacts of the program on these outcomes.
Margin of stability ( MS ) at touchdown was investigated using a full body and a reduced kinematic model.
Marine but not plant-based omega-3 fatty acids were positively associated with incident T2D.
Marine foods , lean meats , fruit , medicinal garnishes and spices , tea , alcohol are also moderately consumed.
Marinesco bodies were found in 1-2% of the substantia nigra neurons , but not in adjacent brain areas.
Marital status modified the association between BZDs and RTCs , particularly among younger male drivers.
Marked hepatic neutrophil infiltration was first detected in 3-week mice , whereas histological evidence of liver injury was not detected until 6-weeks of age.
Marked improvements in maximal leg muscle strength , rapid force capacity and functional performance were observed following the period of biofeedback-based Nintendo Wii training.
Markedly elevated lactate levels in the setting of a normal ScvO2 was associated with significantly higher incidence of major complications and prolonged length of stay.
Marker of bone resorption C-terminal telopeptide of collagen I and 25-hydroxy vitamin D were analyzed in serum.
Markers associated with long lifespan and intermediate Lim3A transcription were present in the population at high frequencies.
Markers indicating oxidative damage were present in chronically ischemic rabbit prostate tissue.
Markers of body composition , grip strength and fasting blood samples were collected.
Markers of immune activation were negatively associated with cognitive function , but did not change the associations between testosterone and cognitive performance.
Markers of ovarian reserve in pregnant women and women without pregnancy were similar.
Markers of oxidative stress were examined by using fluorometric analysis and enzyme immunoassay.
Markers of retinal neurodegeneration are associated with markers of cerebral atrophy , suggesting that retinal OCT may provide information on neurodegeneration in the brain.
Markers of severity of TTC attacks directly correlated with NO responsiveness , while extent of recovery at @number@ months varied inversely with ADMA concentrations.
Markers of target-organ damage and 24-hour ambulatory blood pressure ( BP ) measurement improve cardiovascular risk stratification.
Markers on chromosome 9p21.2 flanked by LINGO2 met a predetermined threshold of genome-wide significance ( P < @number@ × 10 ( @number@ ) ) .
Marker sway amplitude and velocity in sitting were age dependent , with reduced sway amplitude and velocity with increased age for all segments.
Markets are mechanisms of social exchange , intended to facilitate trading.
MARP and DP were determined for trunk forward bending and backward return tasks with self-selected slow and fast paces.
MAR ranged from @number@ for the sweet drink cluster to @number@ for the pasta / rice dish cluster.
Marriage and caregiving encourage socializing and limit television watching , despite differential effects on physical activity and sleep.
Married children were less likely to coreside than unmarried children , but married daughters were more likely than married sons to coreside.
Married couples are affected frequently , and psychiatric problems usually affect marital satisfaction.
Married people and nonsmokers , however , benefit directly in their immediate mortality.
Married students had greater academic / clinical exposure and greater knowledge about aging but less permissive attitudes toward elderly sexuality.
Marrow and blood mononuclear cells were stained with Hoechst dye and the SP-HSC profiles acquired.
Marrow was obtained from the femoral head and trochanteric region of the femur at surgery for total hip replacement ( N = 100 ) .
Masculine gender scripts have been influential in health decision making in men.
Masculinity is a social construction that defines itself according to context.
MA-SED and @number@ + SED displayed a higher hybrid type IIa / IIx fibre proportion vs. YA.
MA significantly inhibited UVR-induced melanin synthesis and melanosome transfer in the co-culture system.
MA significantly reduced UV-induced melanin index at @number@ weeks after topical application.
Masked graders evaluated enface angiodisc OCTA data.
Massive hemoptysis is a medical emergency and needs immediate treatment.
Massive orofacial hemorrhage mostly occurs in younger individuals unilaterally and is associated with extensive LeFort fractures.
Mass-spectra were obtained with time-of-flight mass-spectrometer Autoflex III ( \ "Bruker Daltonics \ " ) in automatic mode.
Mass spectrometric analyses revealed that both Lys63-linked and Met1-linked polyubiquitin chains are associated with the IKK complex.
Mass spectrometric analysis revealed extensive mitochondrial proteomic alterations in SH-SY5Y cells based on oxygen culture condition.
Mass spectrometry analysis identified specific lysine residues , including lysine @number@ ( K280 ) within the microtubule-binding motif as the major sites of tau acetylation.
Mass spectrometry and antibodies have been used to identify PK cleavage sites in PrP ( Sc ) .
Mass spectrometry identified two unique serine residues that were phosphorylated by Plk3.
Mass spectroscopy was performed on BCE-ECM to examine the protein composition.
Mast cell mediators differentially affected the release of chemokines CCL8 , CCL13 , CXCL4 and CXCL6 by fibroblasts.
Mast cells are probably a main factor that potentially can be involved in tissue damage and aging changes in skin.
Mast cells should be regarded as an important target for anti-aging therapy.
Mast cells , whose number increases with aging , may influence dermal fibroblast number with aging.
Master athletes are more than @number@ years of age and continue to train as hard as their young counterparts despite the aging process.
Master athletes showed a weak correlation ( r = -0·295 , P = 0·010 ) between MUNIX and age.
Masters athletes may experience low back pain from multiple sources.
Master sprint-trained athletes were not the main focus of attention.
Mastery was consistently related to higher well-being , with the strongest associations evident for young adults.
Mastery was found to moderate the relationship between anticipated stigma and depressive symptoms among older adults.
Masticatory performance was determined by the comminuted particles of test food.
Matched administrative records identified @number@ former foster youth who were eligible for the housing program during 2007-2010.
Matched control patients were those recruited from the hospital providing usual care.
Matching criteria were sex , diabetes , cirrhosis , pre-PVO chemotherapy and bevacizumab administration , and jaundice.
Matching methods require active motion and are consequently influenced by additional sensorimotor processes.
Matching on potential mediators generally decreased the effect estimate among black people.
Matching was based on preintervention performance with regard to the quality measures.
Mate availability at sexual maturity may be linked via several biological and social mechanisms to long-term survival in men.
MATERIAL AND METHOD : An experimental , prospective , single blind study was conducted.
MATERIAL AND METHOD : @number@ people ( @number@ women and @number@ men , age 18-79 years ) were examined.
MATERIAL AND METHOD : One hundred and twenty nine patients with isolated systolic hypertension at office were included.
MATERIAL AND METHOD : Patients were recruited from the check-up clinic.
Material and methods.
MATERIAL AND METHODS : According to the severity of the imbalance , three stages are observed : balanced , balanced with compensatory mechanisms and imbalanced.
MATERIAL AND METHODS : A cross-sectional study in @number@ healthy children aged between @number@ and @number@ years.
MATERIAL AND METHODS : A cross-sectional study was performed in @number@ men aged > 50 years in Beijing.
MATERIAL AND METHODS : All indicators were derived from the ISTAT Health for All database.
MATERIAL AND METHODS : A prospective descriptive study of people ( > 75 year´s ) attending ED´s in seven countries , including Iceland.
MATERIAL AND METHODS : A total of @number@ digital panoramic radiographs of individuals aged between @number@ and @number@ years were selected.
MATERIAL AND METHODS : A total of @number@ elderly patients , above @number@ years of age , underwent penile prosthesis implantation between @number@ and @number@
MATERIAL AND METHODS : A total of @number@ individuals of two samples , ranging from @number@ to @number@ years old , were analyzed.
MATERIAL AND METHODS : A total of @number@ patients were examined.
MATERIAL AND METHODS : A total of @number@ workers participated.
MATERIAL AND METHODS : Between @date@ and @date@ @number@ patients underwent surgery for pHPT.
MATERIAL AND METHODS : Chen’s Personal Social Capital scale was applied to @number@ women aged between @number@ and @number@ years during @number@
MATERIAL AND METHODS Clinical data from @number@ SAH patients who underwent surgical clipping of anterior circulation aneurysms were reviewed retrospectively.
MATERIAL AND METHODS : Data is derived from the questionnaire survey conducted on 50 + employees ( @number@ women and @number@ men ) .
MATERIAL AND METHODS : Eighty four consecutive patients with urinary incontinence were enrolled in this study.
MATERIAL AND METHODS : Eighty patients with multiple actinic keratoses related to chronic photodamage underwent one or two sessions with daylight PDT.
MATERIAL AND METHODS : Fifty elderly patients and @number@ young patients were selected.
MATERIAL AND METHODS : Fifty-two patients were treated for 3-6 sessions using fractional RF handpiece and eight patients received combination treatments with non-invasive RF handpiece.
MATERIAL AND METHODS : Forty-eight extracted molars were prepared by use of a standardized preparation design.
MATERIAL AND METHODS : Forty-two patients were admitted to our clinic with signs of LDH and underwent surgery for LDH at @number@ IVD levels.
MATERIAL AND METHODS HUVEC were exposed to H2O2 to establish the aging model.
MATERIAL AND METHODS : Images of ninety Mongoloids patients examined with i-CAT Cone Beam Computed Tomography were included.
MATERIAL AND METHODS : In a prospective randomized study involved @number@ patients scheduled for elective MAS , aged 65 + .
MATERIAL AND METHODS : Longitudinal clinical research was conducted.
MATERIAL AND METHODS : @number@ patients underwent carotid endarterectomy in 2013-2014 in the Vascular Surgery Department of the Pomeranian Medical University in Szczecin.
MATERIAL AND METHODS : @number@ persons in age @number@ and more ( @number@ women and @number@ men ) participated in the study.
MATERIAL AND METHODS : Our surgery database was reviewed to identify patients who underwent right-sided laparoscopic adrenalectomy with a retroperitoneal or transperitoneal approach since @number@
MATERIAL AND METHODS : People aged ≥60 were selected.
MATERIAL AND METHODS : Performance and stereotypes were contrasted before and after the cognitive stimulation program.
MATERIAL AND METHODS : Questionnaire based research was conducted in @number@ on a sample group of @number@ seniors.
MATERIAL AND METHODS : Sixty volunteers were recruited.
MATERIAL AND METHODS : Teleradiographs of the lower limbs taken in children with unilateral congenital or posttraumatic deformity were retrospectively reviewed.
MATERIAL AND METHODS : Telomere length was measured in buccal epithelial cells and leukocytes in PD patients and controls.
MATERIAL AND METHODS : The information content in the article comes from studies performed on groups of children of different ages.
MATERIAL AND METHODS : The occlusal dentin surfaces of @number@ human molars were exposed and flattened.
MATERIAL AND METHODS : The operative material obtained after resection of the aorta for its dissection was examined.
MATERIAL AND METHODS : The present study included lead exposure patients ( n : @number@ ) and control subjects ( n : @number@ ) .
MATERIAL AND METHODS : The research involved @number@ persons in the early and late adulthood stage ages.
MATERIAL AND METHODS : The sample consisted of @number@ healthy participants ranging in age from @number@ to @number@ years.
MATERIAL AND METHODS : The sample consisted of @number@ participants who are cognitively normal and range in age from @number@ to @number@ years.
MATERIAL AND METHODS : The sample included @number@ subjects with an age range of 30-85 years.
MATERIAL AND METHODS : The study group consisted of new-onset type @number@ diabetic patients admitted to our hospital between @date@ and @date@ .
MATERIAL AND METHODS : The study group consisted of @number@ women scheduled for reconstructive surgery due to POP.
MATERIAL AND METHODS : The study included @number@ participants aging between @number@ and @number@ years.
MATERIAL AND METHODS : The study involved @number@ women , aged 60-75.
MATERIAL AND METHODS : The study material were kidney tissue samples taken from fifty-six cadavers , their age ranging from @number@ to over @number@ years.
MATERIAL AND METHODS : The study population comprised the complete cohort of @number@ men who underwent RP between @number@ and @number@
MATERIAL AND METHODS : The study was carried out retrospectively.
MATERIAL AND METHODS : The study was performed in postmenopausal women.
MATERIAL AND METHODS : The substudy included @number@ of @number@ subjects aged @number@ years or over , participants of the population-based PolSenior study.
MATERIAL AND METHODS : This is a case-control study that included @number@ patients diagnosed with AMD and @number@ matched healthy controls.
MATERIAL AND METHODS : This study included @number@ participants from the Berlin aging study II ( BASE-II ) .
MATERIAL AND METHODS : Twenty Korean patients with moderate-to-severe nasolabial fold wrinkles were enrolled.
MATERIAL AND METHODS : Twenty-seven anterior partial fixed dental prostheses of @number@ to @number@ units were fabricated.
MATERIAL AND METHODS : We enrolled in this study @number@ subjects who due to chronic As exposure suspected and @number@ subjects as a control group.
MATERIAL AND METHODS : We evaluated @number@ patients.
MATERIAL AND METHODS : We have conducted a population-based , retrospective cohort study with follow-up.
MATERIAL AND METHODS : We identified @number@ cases with the Surveillance Epidemiology and End Result ( SEER ) database.
MATERIAL AND METHODS : We performed a cross-sectional study on a sample consisting of @number@ participants.
MATERIAL AND METHOD : Twenty patients with mild to moderate facial wrinkle were included in the study.
MATERIAL AND METHOD : We describe the general development of bacterial resistance and factors that influence it.
Material-dependent binding effects were also present for both groups in ventrolateral prefrontal and parahippocampal cortices for words and objects , respectively.
MATERIAL / METHODS : A literature search for SRs with meta-analyses was performed in PubMed and Cochrane library databases up to @date@ .
MATERIAL / METHODS : A total of @number@ Uygur and @number@ Kazak clinically normal subjects were included in this study.
MATERIAL / METHODS : Study participants were @number@ healthy individuals from @number@ different age groups , observed from @date@ to @date@ .
Materials and funding for this study were provided by Teoxane , Geneva , Switzerland.
MATERIALS AND METHOD : Data from the Global Adult Tobacco Survey ( GATS ) on socio-demographic and smoking-related characteristics of respondents were used.
MATERIALS AND METHODS : A cadaveric anatomical study was performed by dissection of superficial and deep facial fat compartment of @number@ body.
MATERIALS AND METHODS : Adriamycin-induced aging model was established on SMCC7721 liver cancer cell line.
MATERIALS AND METHODS : A lifeworld hermeneutical approach was used.
MATERIALS AND METHODS : A literature review was performed to identify all published articles of PAE for BPH.
MATERIALS AND METHODS : A literature search was conducted using PubMed from @number@ to @number@
MATERIALS AND METHODS : All @number@ enrolled participants were Koreans ( Fitzpatrick skin types II-IV ) with horizontal neck wrinkles.
MATERIALS AND METHODS : A multicentre cross-sectional study was carried out in @number@ Italian schools of public health.
MATERIALS AND METHODS : A multisite cross-sectional study was carried out across four memory care practices in the greater Indianapolis area.
MATERIALS AND METHODS : An angular artery cutaneous flap was designed to repair the defect.
MATERIALS AND METHODS : A phospho-kinomic screen was used to identify downstream effectors of FLT3-ITD.
MATERIALS AND METHODS : A prospective cohort study in the ICU of the University Hospital Center of Tirana , Albania , was conducted.
MATERIALS AND METHODS : A prospective observational study was undertaken from @date@ to @date@ .
MATERIALS AND METHODS : A quasi-experimental longitudinal study was carried out in two comparable nursing homes.
MATERIALS AND METHODS : A randomized experimental design was used in this study.
MATERIALS AND METHODS : A retrospective chart review of @number@ consecutive inpatients with @number@ heel decubitus ulcerations was performed.
MATERIALS AND METHODS : A retrospective review was conducted on @number@ patient episodes.
MATERIALS AND METHODS : A review of published articles on eyelid tightening using blepharoplasty and lasers was conducted.
MATERIALS AND METHODS : A review of published evidence was performed using Medline.
MATERIALS AND METHODS : A review of the literature was performed.
MATERIALS AND METHODS : A sample of @number@ persons underwent clinical and neuropsychological evaluation to establish mild cognitive impairment diagnosis.
MATERIALS AND METHODS : As part of the international PRISMA project , a representative telephone survey was carried out in Germany.
MATERIALS AND METHODS : Asymptomatic men underwent a health check-up program between January and @date@ .
MATERIALS AND METHODS : A total of @number@ community-dwelling older adults ( @number@ were men ) completed the ABC-H scale.
MATERIALS AND METHODS : A total of @number@ consecutive patients submitted to ureteral-stent removal were considered.
MATERIALS AND METHODS : A total of @number@ disc-shaped specimens were prepared using computer-aided design / computer-aided milling technology from lithium disilicate glass-ceramic blocks.
MATERIALS AND METHODS : A total of @number@ patients ( aged > 60 years ) were enrolled in the study.
MATERIALS AND METHODS : A total of @number@ patients ( @number@ aging upper eyelids ) with upper eyelid sagging were retrospectively examined.
MATERIALS AND METHODS : A total of @number@ volunteers participated in this prospective , randomized , and controlled study.
MATERIALS AND METHODS : Baseline data from the B-PROOF ( B-vitamins for the PRevention Of Osteoporotic Fractures ) study were used.
MATERIALS AND METHODS : Baseline data from the ' Lifelines Cohort Study ' collected between @number@ and @number@ in the Netherlands were used.
MATERIALS AND METHODS : Between @number@ and @number@ @number@ patients with Mild Cognitive Impairment ( MCI ) were included.
MATERIALS AND METHODS : Breast samples were collected from @number@ cancer-free women who had undergone cosmetic mammoplasty.
MATERIALS AND METHODS : Cephalograms from the same subjects in their 20s , 30s , and 40s were analyzed.
MATERIALS AND METHODS : Clinical records were retrospectively reviewed of @number@ eyes that underwent intravitreal ranibizumab therapy for exudative AMD.
MATERIALS AND METHODS : Crown segments of @number@ human non-carious molars were bonded using simulated pulpal pressure at @number@ cm water pressure.
MATERIALS AND METHODS : CT scans of abdominal L4 sections were obtained from Baltimore Longitudinal Study of Aging ( BLSA ) participants.
MATERIALS AND METHODS : Data was collected through independently completed surveys after obtaining IRB approval in a single institution cancer center over a 4-month period.
MATERIALS AND METHODS : Data were collected from four groups of ten participants each.
MATERIALS AND METHODS : Data were obtained from the Alzheimer's Disease Neuroimaging Initiative.
MATERIALS AND METHODS : Different specimens were made for each test of each reliner.
MATERIALS AND METHODS : dVRS were evaluated by using high-resolution 3D MR imaging in @number@ subjects enrolled in the 3C-Dijon MR imaging study.
MATERIALS AND METHODS : Eighty human molars were embedded in acrylic resin and sectioned @number@ mm below the occlusal plane.
MATERIALS AND METHODS : Eighty patients with a diagnosis of knee OA were enrolled.
MATERIALS AND METHODS : Eligible patients met @number@ criteria.
MATERIALS AND METHODS : Evidence from the databases , mainly from PUBMED and SCIENCE DIRECT were considered.
MATERIALS AND METHODS : Fifty-four women over @number@ years old underwent surgery for benign gynecological disease from @date@ to @date@ .
MATERIALS AND METHODS : Fifty patients ( 50-64 years ) with ED and LOH were selected.
MATERIALS AND METHODS : Fifty-two subjects ( aged @number@ ± @number@ years ) with variable degrees of cardiovascular risk underwent abdominal surgery for intercurrent diseases.
MATERIALS AND METHODS : Five erythrocyte concentrates were followed weekly during @number@ days.
MATERIALS AND METHODS : Flat dentin surfaces were obtained from @number@ sound molars , from which @number@ were microbiologically processed for induction of caries.
MATERIALS AND METHODS : For this observational study , we selected individuals from the general population of Ohasama , a rural Japanese community.
MATERIALS AND METHODS : Forty ( @number@ @date@ mm ) feldspathic porcelain disks were prepared and divided into four equal groups.
MATERIALS AND METHODS : Fourteen patients with laser toning-associated facial depigmentation were assessed with cross-polarized and ultraviolet ( UV ) photographic images.
MATERIALS AND METHODS : From @number@ to @number@ @number@ distal humeral fractures were treated operatively by perpendicular dual plating osteosynthesis.
MATERIALS AND METHODS : Gastric epithelial AGS or MKN-45 cells were co-cultured with wild-type or cagA ( - ) H. pylori strains.
MATERIALS AND METHODS : Genes were studied by direct sequencing of DNA extracted from formalin-fixed paraffin-embedded tissues.
MATERIALS AND METHODS : Healthy women with moderate-to-severe décolleté skin lines and wrinkles were enrolled.
MATERIALS AND METHODS : Heparinized human blood samples were incubated with ibogaine ( @number@ and @number@ μM ) at 37°C for 1h.
MATERIALS AND METHODS : Human dermal fibroblasts and Skh-1 hairless mice were irradiated with UV and treated with PLE.
MATERIALS AND METHODS : Human lens epithelial cells ( HLECs ) were induced by glucose as the model group.
MATERIALS AND METHODS : Human premolars were restored using antioxidant-doped adhesives.
MATERIALS AND METHODS : Human volunteers consented to having controlled placement of HA intradermally into forearm or buttock skin.
MATERIALS AND METHODS : IlluminOss™ was inserted transpedicularly via a balloon / catheter system in @number@ human cadaveric lumbar vertebrae.
MATERIALS AND METHODS : IM was measured by superimposing two sentences from the OLSa.
MATERIALS AND METHODS : In this cross-sectional study , @number@ women enrolled in a mobile phone-based physical activity education trial were analyzed.
MATERIALS AND METHODS : In this review , we analyzed anatomy , pathophysiology and existing classifications of posterior tibial tendon dysfunction.
MATERIALS AND METHODS : Material was @number@ sciatic nerve samples , obtained from cadavers whose age ranged from @number@ to @number@ years.
MATERIALS AND METHODS : Measurements ( anthropometrics , fasting venipuncture and blood pressure ) were performed at the beginning of the seventh and eighth grades.
MATERIALS AND METHODS : Medline , PsychINFO , and Embase were searched from inception to @date@ .
MATERIALS AND METHODS : Medline via PubMed and Embase was systematically searched using prespecified terms.
MATERIALS AND METHODS : mRNA levels of 5HT receptors in MIN6 cells were quantified by RT qPCR.
MATERIALS AND METHODS : MTOPS enrolled @number@ men , and of these , @number@ had total testosterone ( TT ) measured at baseline.
MATERIALS AND METHODS : Multiple regression analysis was undertaken.
MATERIALS AND METHODS : Nine Italian thrombosis centres utilising the Zeus dosing algorithm were involved.
MATERIALS AND METHODS : Nine patients underwent one full-face treatment.
MATERIALS AND METHODS : Ninety-six patients ( @number@ treatments ) had photodamage treated with field-directed ALA-PDT from @number@ to @number@ in this single-center study.
MATERIALS AND METHODS : Nonbiological causes are excluded , and the category \ "all diseases \ " is studied.
MATERIALS AND METHODS : @number@ BPH cases and @number@ controls were enrolled in the study.
MATERIALS AND METHODS : @number@ patients from nine hospitals in the Beijing area were enrolled into this study.
MATERIALS AND METHODS : @number@ subjects with chronic low back pain due to sagittal imbalance were compared to @number@ normal subjects.
MATERIALS AND METHODS : Oesophagus tissue samples from @number@ male cadavers were taken from the cranial and thoracic parts.
MATERIALS AND METHODS : Older people tend to have fewer teeth and some are edentulous.
MATERIALS AND METHODS : One hundred women were questioned about their sleep position preference.
MATERIALS AND METHODS : Orbignya speciosa extract was obtained from the kernels , a nanoparticulate system was developed and acute toxicity test was performed.
MATERIALS AND METHODS : Participants enrolled in CaPSURE™ reported sexual and urinary scores before and after radical prostatectomy using UCLA-PCI.
MATERIALS AND METHODS : Participants were drawn from the population-based Helsinki Aging Study.
MATERIALS AND METHODS : Patients aged @number@ and over , newly diagnosed were recruited at the Jewish General Hospital , Montreal , Canada.
MATERIALS AND METHODS : Patients ( n = @number@ ) seeking skin rejuvenation underwent CO2 laser resurfacing.
MATERIALS AND METHODS : Patients with severe carotid stenosis were recruited either in the CAS group or in the medication group.
MATERIALS AND METHODS : Primary data were for registered patients with malignant laryngeal tumors in the whole country during the period of 1999-2014.
MATERIALS AND METHODS : Pulsed ASL imaging was performed in @number@ neonates with a postmenstrual age from @number@ to @number@ weeks.
MATERIALS AND METHODS : QPEI nanoparticles were added to an orthodontic adhesive at @percent@ , @percent@ and @percent@ wt / wt.
MATERIALS AND METHODS : Samples of ' living ' hydroxyapatite from the anterior maxilla , zygoma , and mandible of @number@ patients were analyzed.
MATERIALS AND METHODS : Seventeen PAD patients performed two experimental sessions : control ( C ) and resistance exercise ( R ) .
MATERIALS AND METHODS : Seventy-eight healthy subjects with ages ranging from @number@ days to @number@ years were included in this study.
MATERIALS AND METHODS : Six databases were searched from inception through @date@ , without language restriction.
MATERIALS AND METHODS : Sixteen subjects with photoaging were enrolled in this prospective , randomized , split-faced study.
MATERIALS AND METHODS : Sixty Class II cavities were prepared in extracted mandibular third molars , with margins extending @number@ mm below the cementum-enamel junction.
MATERIALS AND METHODS : Sixty-four human third molars and four restorative systems were used.
MATERIALS AND METHODS : Subjects were randomized into four groups ( N = 12 / group ) .
MATERIALS AND METHODS : Surface-based morphometry was performed on @number@ patients with amyotrophic lateral sclerosis and @number@ age- and sex-matched healthy control participants.
MATERIALS AND METHODS : Symptoms , clinical parameters and serum metabolites were measured before and after @number@ and @number@ weeks of R6 treatment.
MATERIALS AND METHODS : Systematic review of the literature published between inception of the databases and @date@ .
MATERIALS AND METHODS : Ten female subjects with photodamaged skin were enrolled in this study.
MATERIALS AND METHODS : Ten Korean female volunteers with mild to severe NLFs were enrolled.
MATERIALS AND METHODS : The abdominopelvic CT scans of @number@ patients divided equally into seven age groups were retrospectively reviewed.
MATERIALS AND METHODS : The authors reviewed the literature from the points of view of efficacy and safety and availability.
MATERIALS AND METHODS : The effects of HCT on cell death were determined using the MTT assay.
MATERIALS AND METHODS : The functional QAS and their constructed PQAS were synthesized , characterized and formulated into the experimental high-strength cements.
MATERIALS AND METHODS : The institutional review board approved this prospective study and waived informed consent.
MATERIALS AND METHODS : The Institutional Review Board of our hospital approved this retrospective study and patient informed consent was waived.
MATERIALS AND METHODS : The occlusal dentin surfaces of @number@ teeth were ground flat.
MATERIALS AND METHODS : The participants were @number@ women , aged 63-79 years , with osteopenia or osteoporosis.
MATERIALS AND METHODS : The present study was performed after the approval of the local Committee of Ethics in Research.
MATERIALS AND METHODS : The proposed model simulated the trabecular changes for an age span of 32-80 years.
MATERIALS AND METHODS : The sample included healthy human subjects ( n = @number@ ) between the ages of @number@ to @number@ years.
MATERIALS AND METHODS : The silicone elastomers tested were low- and high-temperature vulcanizing materials , namely , Premium and Silasto @number@ respectively.
MATERIALS AND METHODS : The study included @number@ larynx preparations obtained from open partial and total laryngectomies ( F-7 ; M-43 ) .
MATERIALS AND METHODS : The study included @number@ men ( aged 20-79 years ) and @number@ women ( aged 20-81 years ) .
MATERIALS AND METHODS : The study included @number@ older ( mean age 67±5.9years ) and @number@ younger ( @number@.1±1.8years ) women.
MATERIALS AND METHODS : The study involved @number@ patients suffering from severely progressive FMS.
MATERIALS AND METHODS : The study participants were recruited from a cohort of Danish men born in @number@
MATERIALS AND METHODS : The study population consisted of @number@ patients with mild AD and @number@ cognitively normal elderly.
MATERIALS AND METHODS : The T2 and ADC values were recorded from @number@ IVDs of @number@ volunteers.
MATERIALS AND METHODS : The water extract of CR was prepared and fingerprinted using high-performance liquid chromatography ( HPLC ) .
MATERIALS AND METHODS : Thirty extracted teeth were prepared and then divided in three groups.
MATERIALS AND METHODS : Thirty women aged @number@ to @number@ were enrolled in this single-center prospective 16-week study.
MATERIALS AND METHODS : This is a cross sectional study performed with men between @number@ and @number@ years undergone to check-up.
MATERIALS AND METHODS : This is a prospective cross-sectional study of @number@ healthy children.
MATERIALS AND METHODS : This quasi-experimental intervention study was carried out on @number@ elderly citizens of Arak.
MATERIALS AND METHODS : This retrospective analysis comprised @number@ patients ( @number@ eyes ) .
MATERIALS AND METHODS : This retrospective study did not use private identifiable information and thus did not constitute human subjects research.
MATERIALS AND METHODS : This study was approved by the institutional review board and was HIPAA-compliant.
MATERIALS AND METHODS : This study was approved by the local ethics review board , and informed consent was obtained from volunteers / guardians.
MATERIALS AND METHODS : This was a case-control study whereby @number@ elderly men were recruited from the community and the Urology and Geriatrics ambulatories.
MATERIALS AND METHODS : This was a cross-sectional study of @number@ Japanese men ( age : 30-79 years ) .
MATERIALS AND METHODS : This was a retrospective study of aged @number@ to @number@ years.
MATERIALS AND METHODS : Three groups ( benign control , high-risk , and PSC ) of patients with matched ages were studied.
MATERIALS AND METHODS : Total fat was identified in the feature space of Hounsfield units and divided into subcutaneous and visceral components using model-based segmentation.
MATERIALS AND METHODS : Total @number@ subjects were recruited in this prospective study.
MATERIALS AND METHODS : To validate the Italian version of the VMMSE , we compared its performance with standard F2F.
MATERIALS AND METHODS : Treatment was administered using an AFP device and assessed photographically @number@ months after treatment by a blinded physician.
MATERIALS AND METHODS : Twenty-five subjects were treated with FxCR on the bilateral inner arms.
MATERIALS AND METHODS : Twenty-five tissue samples were obtained from eleven patients undergoing Mohs micrographic surgery to remove NMSC tumors.
MATERIALS AND METHODS : Twenty Japanese patients were treated on requested body areas.
MATERIALS AND METHODS : Twenty patients with BPH , aging 68-78 years old ( y.o ) , were enrolled in the study.
MATERIALS AND METHODS : Twenty-seven women were recruited in order to examine the effects of cosmetic make-up on first impressions.
MATERIALS AND METHODS : Twenty specimens from each type of tested composite resin material were prepared.
MATERIALS AND METHODS : Twenty-two voluntary individuals , aged between @number@ and @number@ years , were evaluated.
MATERIALS AND METHODS : Two hundred human molars were prepared and divided into @number@ groups ( n = 10 / group ) .
MATERIALS AND METHODS : Two hundred patients at steady-state on long-term perhexiline were identified retrospectively.
MATERIALS AND METHODS : Ultrasound examinations from @number@ unique pediatric patients with normal appendixes , evenly distributed by age , were reviewed.
MATERIALS AND METHODS : Validity was assessed by comparing measurements from the VRHMD to measurements of postural sway from a force plate.
MATERIALS AND METHODS : We analyzed the expression and prognostic significance of eEF1A2 in @number@ primary non-small cell lung cancer ( NSCLC ) cases.
MATERIALS AND METHODS : We assessed @number@ participants in the FHS for paraseptal emphysema on chest CT.
MATERIALS AND METHODS : We conducted a cross-sectional study based on a national representative sample of @number@ adults of @number@ years of age and older.
MATERIALS AND METHODS : We conducted a secondary analysis of a prospective cohort study on @number@ patients aged ≥65 years hospitalized on geriatric wards.
MATERIALS AND METHODS : We conducted four focus groups with older adult participants ( n = 31 ) at an independent retirement community.
MATERIALS AND METHODS : We designed a questionnaire with @number@ items representing @number@ themes that emerged from prior in-depth interviews with ICU patients and families.
MATERIALS AND METHODS : We enrolled @number@ naive patients with HCC who were treated initially by RFA from @number@ to @number@
MATERIALS AND METHODS : We established a computer model based on an elementary computational cell.
MATERIALS AND METHODS : We evaluated deceased subjects aged @number@ years or above.
MATERIALS AND METHODS : We evaluated @number@ participants from the Rush Memory and Aging Project with antemortem structural T1-weighted MR imaging and postmortem neuropathologic assessments.
MATERIALS AND METHODS : We evaluated @number@ patients who donated living kidneys between @number@ and @number@ at Baskent University Hospital.
MATERIALS AND METHODS : We examined T1WI and T2WI obtained from @number@ neonates who showed normal development at their 2-year follow-up examinations.
MATERIALS AND METHODS : We identified @number@ incident simvastatin and atorvastatin users in the Rotterdam Study , a population-based cohort study.
MATERIALS AND METHODS : We identified @number@ men on active surveillance whose first biopsy occurred between @number@ and @number@
MATERIALS AND METHODS : We performed a prospective cohort study over @number@ years.
MATERIALS AND METHODS : We prospectively collected the data of trauma patients , aged @number@ and older , presenting to our Emergency Department.
MATERIALS AND METHODS : We prospectively studied patients who underwent facial rejuvenation using a minimal undermining suspension technique ( MUST ) in an outpatient setting.
MATERIALS AND METHODS : We recruited @number@ breastfeeding infants at a health clinic in metropolitan Quetzaltenango , Guatemala.
MATERIALS AND METHODS : We retrospectively reviewed for RILF @number@ consecutive Hodgkin lymphoma ( HL ) patients treated with sequential chemo-radiotherapy ( CHT-RT ) .
MATERIALS AND METHODS : We studied @number@ patients aged > 70 y underwent curative resections for NSCLC.
MATERIALS AND METHODS : We surgically treated @number@ patients for colorectal cancer , aged over @number@
MATERIALS AND METHODS : We used data from the Korean Longitudinal Study of Aging ( KLoSA ) from @number@ to @number@
MATERIALS AND METHODS : We use the 2011 / 2012 Chinese Longitudinal Healthy Longevity Survey data ( n = @number@ ) for this paper.
MATERIALS AND METHODS : X-ray films of @number@ subjects aged between @number@ and @number@ years from more than @number@ countries were recruited.
MATERIALS AND METHOD : The study included @number@ persons - @number@ men and @number@ women.
MATERIALS AND METHOD : This study included a literature review of the features that make the gaze appear attractive.
Materials generally decreased in L and increased in b .
MATERIALS / METHODOLOGY : Adult female bonnets were randomized to three social pens ( N = @number@ each ) .
MATERIALS & METHODS : As a matched case-control analysis showed similar efficacy for ISAV and AMB , a cost-minimization approach was taken.
MATERIALS & METHODS : Axillae of @number@ persons were treated by either IPL ( intense pulsed light ) or hot wax for @number@ weeks.
MATERIALS & METHODS : Fifty-three consecutive subjects with PD or parkinsonisms at risk of falls were included and followed for @number@ months.
MATERIALS & METHODS : Seventy-one patients undergoing aortic valve replacement were analyzed in prospective observational study.
MATERIALS / METHODS : The sample consisted of @number@ lateral cephalograms ( @number@ females and @number@ males ) of the Zurich Craniofacial Growth Study.
MATERIALS & METHODS : Twelve female subjects were enrolled and received five sessions of treatments at 2-week intervals.
Materials ( p < @number@ ) and aging ( p < @number@ ) significantly influenced the distribution of failure modes.
Material type and the application of IDS significantly affected the results ( p = 0.013 ) .
Material was right kidney's tissue of @number@ cadavers obtained during routine autopsies.
Material was samples of hypophysis and psoas major muscle of @number@ cadavers of both genders , aged from @number@ to @number@ years.
Material was tissue of the pituitary gland of the @number@ male cadavers.
Maternal age and alcohol consumption were not associated with the outcome ( p > @number@ ) .
Maternal age , meiotic nondisjunction error and telomere length of mother of trisomic child are someway associated.
Maternal and reproductive health remains a key cause of disease burden in adolescent females , especially in lower-SDI countries.
Maternal antibody and absence of comorbidity may explain the low influenza burden whereas parental anxiety may explain the increased healthcare visit rate during the pandemic.
Maternal arsenic exposure was estimated from drinking water samples taken from wells used during the first trimester of pregnancy.
Maternal deflections of the conversational turn to the child predicted the amount of information children later reported about the early-life events.
Maternal grooming / licking behaviour , and corticosterone basal levels were similar among cross-fostered and normally-reared individuals.
Maternal inheritance then circumvents incremental accumulation of age-related disease in each new generation.
Maternally supplied transcripts were detected at 0-2 hpf.
Maternal PlGF and sFlt-1 levels in the first or second trimester were not associated with childhood retinal venular caliber.
Maternal prenatal folic acid supplement intake was the main exposure of interest.
Maternal residential PM2.5 exposure during pregnancy was estimated using a high-resolution spatial-temporal interpolation method.
Maternal residential traffic exposure correlated inversely with telomere length at birth.
Maternal separation is a commonly used model of early life neglect , but has led to inconsistent results in the mouse.
Maternal smoking patterns during pregnancy were assessed by questionnaires.
Maternal traffic exposure was determined using a geographic information system.
Maternal treatment with pan NOS inhibitors during early organogenesis caused severe malformations of the axial skeleton.
Maternal unconjugated E3 concentrations were assessed in plasma in early gestation ( around wk @number@ ) .
Maternity services are struggling.
Math.
Mathematical formulations of the KCT problem in the literature are not compact and do not provide good solution bounds.
Mathematical modeling confirmed that differential selection of older cells is sufficient to cause the observed demographic shift in the fungal population.
Mathematical modeling indicated that full but short and transient Notch signaling required methylation of NICD.
Mathematical modeling offers useful possibilities in clarifying the extent to which different clinical scales measure different phenomena.
Mathematical modeling supports the concept that the presence of older C. neoformans cells emerges from in vivo selection pressures.
Mathematical models taking a population biology perspective are important tools for understanding how the interplay between these factors affects the immune repertoire.
Math relies on mastery and integration of a wide range of simpler numerical processes and concepts.
Matrigel angiogenesis assay was used to analyse the ability of ADSCs to form tubes or networks.
Matrix accumulation can also be observed in fibrotic disorders , such as systemic sclerosis ( SSc ) .
Matrix Gla protein ( MGP ) is a calcification inhibitor in vascular tissue that must be carboxylated by vitamin K to function.
Matrix metalloproteinase-9 ( MMP-9 ) is secreted by macrophages and robustly increases in the left ventricle ( LV ) with age.
Matrix metalloproteinases ( MMPs ) , a family of Zn ( 2 + ) dependent endopeptidases play an important role in those neurodegenerative disorders.
Matrix metalloproteinases ( MMPs ) are known to be involved in IVD degeneration by hydrolyzing the extracellular matrix ( ECM ) , especially the collagens.
Matrix metalloproteinases ( MMPs ) are one of the most important families of proteases involved in the tight control of ECM remodeling over time.
Matrix metalloproteinases perform a crucial role in vascular remodeling.
MAT scores did not differ across administration modes.
Maturation of the vestibular at the ages of @number@ or @number@ years might explain the observed differences between the youngest children and olderchildren.
Maturation status was determined via Tanner stages.
Mature inclusions bear the post-translational hallmarks of human Lewy pathology.
Mature oligodendrocytes , however , can release lactate through the myelin sheath as nutrient for axons.
Maturity was reached around age @number@ for the medium Δx , and by age @number@ for the smallest Δx.
MAWT race / ethnicity- and gender-specific percentile values across age were estimated using regression analyses.
Maximal activation of the lower and upper body for both groups increased only after 20WE.
Maximal activity of @number@ nmol · min · ( @number@ ) mg protein ( @number@ ) was observed for UGT1A1 at @number@ months.
Maximal bone loss occurred within the STRAW stage @number@ and @number@
Maximal digestibility was reached at @number@ min and maintained for @number@ min.
Maximal doses were @number@ mg / d for losartan and @number@ g / d for ω-3.
Maximal drop jump performance from optimal dropping height was measured in a sledge ergometer.
Maximal exercise induces an inflammatory response characterized by leucocytosis and increased IL-6 , MPO and MMP-9 concentrations.
Maximal gait speed , muscle strength , and body balance were assessed at weeks @number@ @number@ and @number@
Maximal grip strength and knee extension strength were assessed with dynometers.
Maximal HR did not change in any group.
Maximal HR for arm exercise was significantly overpredicted compared with age-adjusted prediction equations in both young and older adults.
Maximal inspiratory pressure ( MIP ) and MIP percentage were measured as an indirect index of diaphragm weakness.
Maximal isometric anterior and posterior tongue strength , anterior and posterior swallowing tongue strength , and maximum handgrip strength were measured.
Maximal isometric hip and thigh muscle strength and leg extensor power and active hip ROM were assessed at baseline @number@ @number@ and @number@ months.
Maximal isometric strength of the lower body for both groups increased only at 20WE , while upper-body maximal isometric strength increased after 13WE and 20WE.
Maximal knee extensor forces were also monitored to determine the training effect on muscle function.
Maximal oxygen consumption ( O2MAX , online respiratory gas analysis ) was determined during cycling ergometry.
Maximal oxygen uptake decreased with inactivity ( Y ) and always increased with training.
Maximal respiration and spare respiratory capacity were measured from peripheral blood mononuclear cells from the other subset.
Maximal respiration was significantly lower in older compared to young. n3-PUFA did not change respiration , but significantly reduced oxidant emissions.
Maximal respiratory capacity was significantly reduced in the homogenate compared with the Pfi from human skeletal muscle.
Maximal respiratory pressure decreases @number@ cmH₂O per year.
Maximal resultant torque was simultaneously recorded with the electromyographic activity of quadriceps and hamstring muscles.
Maximal SkBF was measured at the end of both protocols ( @number@ mM SNP ) .
Maximal step-up height below @number@ cm discriminated patients with self-reported severe limitation in physical function.
Maximal strength and endurance were assessed and correlated with intramuscular variables.
Maximal strength and QCSA increased in the HIPRT group and did not change in the CON group.
Maximal velocity , but not torque , was associated with power in OML.
Maximal velocity demonstrated an association with multiple chair rise time and stair climb time in OML , but not MH or OH.
Maximal voluntary contractions and evoked contractions of the knee extensor muscles were performed before and after the exercise.
Maximal voluntary force ( MVC ) , maximal motor unit firing rate , and motoneuron AHP duration were measured on two occasions.
Maximal walking speed , leg extensor power , standing balance and body mass index were measured at the research center.
Maximizing fat loss while preserving lean tissue mass and function is a central goal of modern obesity treatments.
Maximizing symptomatic relief whilst minimizing side effects is the aim of treatment.
Maximizing their NHSC experiences and retention requires recognizing their differences in demographics , debt , and areas of job satisfaction.
Maximizing treatment response thus requires striking a balance between the antiviral and hemolytic activities of ribavirin.
Maximum deviation of SSS to the right side is about 10mm.
Maximum ( end-ventricular systole ) , minimum ( end-ventricular diastole ) , and pre-a-wave volumes were measured using the biplane method of disks.
Maximum frown responder rates at week @number@ were measured to analyze the primary efficacy endpoint.
Maximum ITDs increased by a factor of @number@ from ~160 μs at birth ( P0-1 , first postnatal day ) to @number@ μs in adults.
Maximum IVC diameter was decreased with advancing age ( r = @number@ p = @number@ ) .
Maximum KE and LP power increased approximately twofold in PT compared with ST.
Maximum lifespans differ up to 200-fold between mammalian species.
Maximum oxygen consumption ( Vo2max ) and body composition ( dual-energy X-ray absorptiometry and computed tomography ) were also measured before and after the intervention.
Maximum phonation time was also assessed.
Maximum roughness ( P < 0.05 ) and waviness ( P < 0.01 ) were significantly improved versus saline.
Maximum straight and zigzag walking times were also similar between groups.
Maximum strength of the leg extensors was determined isometrically by force plates.
Maximum voluntary activation of the plantar flexors was assessed using the twitch interpolation technique.
Maximum voluntary HGS was measured for the dominant hand.
Maximum wrinkle depth ( Rmax ) was measured in the forehead.
Maybe the way out this pathway to obesity in the future might be working better , choosing organizational flexibility rather than fixed term.
MBCV is computed from a model of velocity distribution.
MBF ( CPT / rest ) at @number@ month after smoking cessation significantly increased in young smokers , but not in middle-aged smokers.
MBL can be the precursor of chronic lymphocytic leukemia or associated with non-Hodgkin's lymphoma.
MCCs limit activities of daily living ( ADLs ) , yet this association is not well characterized outside of clinical populations.
McFadden analysis for goodness of fit was @number@
( MCH ) -expressing neurons ( MCH neurons ) in the lateral hypothalamus ( LH ) are critical regulators of energy and glucose homeostasis.
MCI , AD and MD were not predictive of short- or long-term mortality.
MCI and dementia were based on clinical assessment and a consensus meeting ; those without MCI or dementia were categorised as normal.
MCI global and subtype diagnosis frequencies were inversely related to the stringency of the criteria.
MCI had lower ePiB than HCS ( left PCC , left IFG , and left and right hipp ) .
MCI had smaller CA1-2 volumes.
MCI individuals showed an impaired olfactory function compared to controls.
MCI is a controversial concept and there is a need for good quality trials examining the efficacy of memory interventions.
MCI is an intermediate state between normal aging and AD , so finding MCI is important for an early diagnosis of AD.
MCI is characterized by cognitive decline departing from normal cognitive aging but that does not significantly interfere with daily activities.
MCI nappers showed decreased nocturnal SWS and A1 subtypes compared to non-nappers.
MCI network's attributes showed an intermediate position between NC and AD , corroborating it as a transitional stage from normal aging to Alzheimer disease.
MCI patients were re-examined at least one year later to determine conversion to AD.
MCI prevalence decreased with increasing number of years of education ( p for linear trend < 0.0001 ) .
MCI prodromic of vascular dementia ( Vasc-MCI ) is thought to be characterized by a multiple domain profile.
MCI produced fewer words than controls in the second-half of the task for all categories ( p < @number@ ) .
MCI subjects also exhibited higher MDA levels compared to controls.
MCI subjects ( n = 111 ) were re-evaluated in Phase @number@ for conversion to AD at least one year after initial assessment.
MCI subjects showed significant FA decline predominantly in the anterior corpus callosum ( p < @number@ corrected for multiple comparisons ) .
MCI was also associated with lower premorbid GCA.
MCI was diagnosed using consensus criteria of the International Working Group on MCI.
MCL also attenuated mRNA levels of multiple pro-inflammatory cytokines and mediators such as iNOS , COX-2 , TNF-α , IL-6 and IL-1β.
MCP-1 was inversely associated with psychomotor speed and complex attention and higher levels of MIP-1β were related to better complex attention.
MCR incidence was higher with older age but there were no sex differences.
MCR subtypes were not mutually exclusive.
MCRswv was associated with deficits in all cognitive domains including memory.
MCSA was more predictive of leg BFLBM than total body BFLBM , and those relationships were stronger in older men.
MCST scoring was calculated based on the number of categories , number of perseverative and non-perseverative errors.
MDA levels were also negatively correlated to GR / GPx ratio ( r = @number@ p = @number@ ) in the AD group.
MD and FA were also associated with widely used clinical scores.
MDBI did not seem to be a trustworthy tool.
MDD diagnosis and MDD characteristics were determined by self-report questionnaires and structured psychiatric interviews.
MD / FF vs FA / FF graph extracted from the femoral neck identifies all healthy individuals , according to DXA results.
Mdm2 functionally inhibits p53 and targets the tumor suppressor protein for degradation.
MDMX , a homolog of MDM2 , also binds to and inhibits p53 transactivation activity , yet it does not possess intrinsic ubiquitin ligase activity.
MDP-based resin cements tend to present higher results than those of other cements types when tested using macro- and microtensile tests.
MD represents a very common pathology , especially in the elderly , as reported in neuropathological studies.
MDS patients showed a TA value of @number@
MD values were strongly correlated with disease duration and ICARS score.
Meals on Wheels volunteers are uniquely suited to coach their clients in such interaction strategies.
Mealtime assistance can enhance nutritional intake , clinical outcomes and patient experience.
Mean ADAS-Cog did not differ between the groups.
Mean adipocyte size increased in association with CLS-B ( P < @number@ ) .
Mean age and disease bilaterality were similar , with a predominance of female patients in the RPOH group ( P = @number@ ) .
Mean age at baseline was @number@ y and median log-Gal-3 was @number@ ( IQR : @number@ @date@ ) ng / ml.
Mean age at baseline was @number@ years ; males were followed for up to @number@ years.
Mean age at biopsy and symptom duration was @number@.62±4.8 years and @time@ ±40.4 months , respectively.
Mean age at diagnosis was @number@ ± @number@ ( men : @number@ ± @number@ women : @number@ ± @number@ ) .
Mean age at the 15-year follow-up was @number@ years.
Mean age at the time of the evaluation was @number@ years ( SD = @number@ ) .
Mean age for the participants was @number@.7± years ; there were @number@ women and @number@ men in each group.
Mean age in the @number@ groups was @number@ years and the majority of men were Caucasians.
Mean age of all participants was @number@ ± @number@ years ( range , 4-84 years ) .
Mean age of participants was @number@.3±4.1 years , @percent@ C.I ( @number@.64-52.88 ) years.
Mean age of participants was @number@ ( @number@ ) years and mean RHR was @number@ ( @number@ ) bpm.
Mean age of participants was @number@ years , @percent@ of participants were men , and @percent@ of participants were black.
Mean age of residents with diabetes in the year @number@ was @number@ compared to @number@ years for others.
Mean age of smoking initiation was lower in men compared to women ( @number@.4±3.6 vs. @number@.0± @number@ p < @number@ ) .
Mean age of the participants was @number@ ( ± @number@ ) , @percent@ were women.
Mean age of the participants was @number@ ± @number@ @percent@ were women and @percent@ were illiterate.
Mean age of the patients was @number@ years , and @percent@ were female.
Mean age of the patients was @number@ years ( range 38 93 years ) .
Mean age of these subjects was @number@ years ( range , 30-60 years ) .
Mean age of the SOP was @number@.4±7 years.
Mean age prior to HIV infection was @number@ years.
Mean age ± SD ( range ) of the subjects was @number@ ± @number@ ( 30-61 ) years.
Mean ages of individuals with IL-6 @number@ C- carriers and C + carriers were @number@.82± @time@ and @number@.82±16.82 years , respectively.
Mean ages were @number@ years for those with AMD and @number@ for those without AMD.
Mean age was 74±3 years , @percent@ were men , @percent@ were black , @percent@ were hypertensive , and @percent@ were diabetic.
Mean age was @number@
Mean age was @number@.7±9.4 years , and mean time since injury was @number@.3±9.2 years.
Mean age was @number@ ± @number@
Mean age was @number@ ± @number@ in subjects with no eyelash whitening ; and @number@ ± @number@ in those with whitening.
Mean age was @number@ ( @number@ ) years.
Mean age was @number@ ± @number@ years.
Mean age was @number@ ± @number@ years.
Mean age was @number@ ± @number@ years and consisted of @number@ men and @number@ women.
Mean age was @number@ ± @number@ years and median Injury Severity Score was @number@ ( interquartile range @number@ to @number@ ) .
Mean age was @number@ ± @number@ years , mean HbA ( 1c ) was @percent@ and mean NT-proBNP was @number@ ± @number@ pg / ml.
Mean age was @number@ ± @number@ years , @percent@ were male , and the mean CCI was @number@ ± @number@
Mean age was @number@ years.
Mean age was @number@ years and mean HbA1c was @percent@.
Mean age was @number@ years and @percent@ were women.
Mean age was @number@ years in SISTEr ( range @number@ to @number@ ) and @number@ years ( range @number@ to @number@ ) in TOMUS.
Mean age was @number@ years , @percent@ were males , and @percent@ were white.
Mean age was @number@ years , @percent@ were women , @percent@ were dependent in ADLs , @percent@ had depression , and @percent@ had dementia.
Mean age was @number@ years ( range 31-74 ) .
Mean age was @number@ years ( range , 35-64 years ) .
Mean age was @number@ years , ranging from @number@ to @number@ years.
Mean age was @number@ years ( SD = @number@ ) for @number@ ( @percent@ ) females and @number@ ( @percent@ ) males.
Mean allium vegetable intake and garlic intake of the study population was @number@.5±12.7g / day and @number@.9±8.8g / day respectively.
Mean AMH concentrations were not modified by past use of oral contraceptive and were independent of parity of women.
Mean AMH concentrations were not modified by smoking habit and BMI and were independent of parity of the women.
Mean antidromic sensory conduction velocity of MNs ( wrist-to-second finger ) or UNs ( wrist-to-fifth finger ) was not different between two genders.
Mean aortic dilatation remains stable in infancy when children receive a β-blocker.
Mean AR mRNA expression and protein concentration remained unchanged after heavy resistance exercise bouts compared to pre-values.
Mean arterial oxygen saturation during sleep was correlated with CBF in all regions.
Mean arterial pressure ( MAP ) and cardiac output ( Q ) were assessed continuously by finger plethysmography and total peripheral resistance was calculated.
Mean ASA score was significantly higher in the Elderly Group.
Mean axial length was @number@ mm.
Mean basal follicle-stimulating hormone ( FSH ) increased from @number@ ± @number@ to @number@ ± @number@ nmol / L ( P = @number@ ) .
Mean basal luteinizing hormone ( LH ) increased from @number@ ± @number@ to @number@ ± @number@ nmol / L ( P < .0001 ) .
Mean baseline eGFR was @number@ mL / min / 1.73m , and @percent@ progressed to an eGFR < @number@ mL / min / 1.73m.
Mean baseline SBP was @number@ mmHg for intervention participants and @number@ mmHg for controls ( P = .10 ) .
Mean baseline serum magnesium and phosphate levels were @number@ mmol / L and @number@ mmol / L respectively.
Mean baseline values of REM-AHI were significantly higher than NREM-AHI in both groups.
Mean baseline WS was @number@ cm / s.
Mean BMI was @number@ ± @number@ kg / m ( @number@ ) .
Mean bodily pain score at the time of the FMP was @number@
Mean body weight loss during training was @number@ ± @percent@.
Mean body weights were significantly decreased in male rats in the @number@ @number@ and @number@ g / kg groups.
Mean BP did not change.
Mean brow height lift and submental lift were calculated.
Mean BUB1B transcripts were reduced by @number@.5-fold with aging and associated with marked reductions in BubR1 protein levels.
Mean cannabis exposure among patients was @number@.67±7.16 g-years.
Mean CDT score was @number@ ± @number@ @percent@ scored > 0 and @percent@ scored @date@ .
Mean cell density of basal epithelium does not change with age ( p = @number@ ) .
Mean cell volume and enhanced anisocytosis proved the most informative morphological indicators.
Mean changes from baseline at the last observation were @number@ ± @number@ and @number@ ± @number@ respectively.
Mean changes from physician- and participant-assessed Facial Wrinkle Scale at maximum contraction from baseline to all postbaseline measurements were significant ( p≤.001 ) .
Mean corneal astigmatism was @number@ D ( @percent@ CI : @number@.89-1.06 ) , also significantly correlated with spherical equivalent in the multivariate model.
Mean correct response rate and mean error degree were calculated for each patient.
Mean cost savings were $ 3.37 per day and $ 716 per patient.
Mean daily caloric intake was @number@ kcal ( @percent@ from carbohydrates ) for younger and @number@ kcal ( @percent@ from carbohydrates ) for older participants.
Mean daily step counts and frequency of physical activity outside the home decreased progressively with age for both men and women.
Mean dietary calcium intake was @number@ ± @number@ mg / day , which is below Australian recommendations.
Mean dietary fiber intake averaged @date@ @number@ g.
Mean differences and size effects were calculated for estimating the effect of the program.
Mean diffusivity and fractional anisotropy were computed from normal-appearing gray and white matter in frontoparietal and subcortical networks.
Mean diffusivity ( MD ) is a sensitive and unique neuroimaging tool for detecting microstructural differences particularly in the areas of the dopaminergic system.
Mean diffusivity of lateral ventricular CSF decreased significantly with age in healthy adults ( r = -0.30 ; p = 0.02 ) .
Mean diffusivity reduction reflected concomitant decrease of both axial and radial diffusivity , without appreciable changes in white matter anisotropy.
Mean disease activity scores at baseline , as measured by DAS28-ESR and DAS28-CRP , were @number@ ± @number@ and @number@ ± @number@ respectively.
Mean dominance durations ( time spent on each percept ) under passive viewing were comparable in PD and NC , and shorter in YA.
Mean doses accumulated in soft tissues and in red bone marrow during the prenatal period were @number@ mGy and @number@ mGy , respectively.
Mean duration of ADT in both groups was approximately @number@ years ( P = @number@ ) .
Mean duration of HRT use was @number@ ± @number@ years in the user sister , while their co-twins had never used HRT.
Mean EFV was @number@ ± @number@ mL.
Mean eGFR was @number@ mL / min / 1.73 m ( @number@ ) .
Mean eGFR was @number@ ml / min / 1.73 m ( @number@ ) ( SD = @number@ ) .
Mean elastography scores and standard deviations were calculated and resting and postexercise elastography scores were compared.
Mean energy derived from saturated fat was above , whereas energy derived from carbohydrate was below , recommended levels of intake at all time points.
Mean energy intake decreased in men and women in all age groups from the first to fifth study waves.
Mean energy intake was @number@ ± @number@ kJ / day and protein provided @number@ ± @percent@ of energy.
Mean EuroQoL EQ-5D index value was @number@.58±0.25 and VAS score @number@.2±23.6.
Mean extraocular muscle density increased slightly with increasing muscle volume ( p = @number@ ) .
Mean fat density increased with decreasing fat volume ( p = @number@ ) .
Mean FI scores significantly increased at each time point for the older rats.
Mean follow-up duration was @number@ ( 0-10 ) years , with @number@ deaths.
Mean follow-up @number@ days ( SD @number@ ) .
Mean follow-up period was ∼11.5 years.
Mean follow-up period was @number@ years.
Mean follow-up time was @number@ ( 6-96 ) months.
Mean follow-up time was @number@ y.
Mean follow up time was @number@ years for African Americans and @number@ years for Yoruba.
Mean follow-up was five years ( SD @number@ ) .
Mean follow-up was @number@ months ( range 12-116 months ) ; @percent@ were men ; @percent@ were white.
Mean follow-up was @number@ months ( range @date@ ) .
Mean follow-up was @number@ ± @number@ months.
Mean follow-up was @number@ ± @number@ years.
Mean follow-up was @number@ years ( range , @number@.3-8 years ) .
Mean fractional anisotropy ( FA ) values in significant areas were calculated for each subject and correlated with cognitive performance.
Mean frictional force ranged from @number@ to @number@ N according to the mouth quadrant , but the difference between groups was also not significant.
Mean FVC for younger subjects was found to be @number@ ± @percent@ of the ECCS reference values and @number@ ± @number@ % in older subjects.
Mean gait speed and @percent@ confidence intervals ( CI ) by category of index were calculated using mixed effects models.
Mean global score for our sample is @number@ suggesting an environment composed both of facilitating and hindering features.
Mean global score of the Hill-Bone High Blood Pressure Compliance Scale was @number@ points.
Mean green / red ratio value for the samples was @number@.11±0.1 ( range @number@ to @number@ ) , with a value ≥0.05 in @number@ patients.
Mean hair thickness generally tended to increase until the 20s , reach a plateau between the 20s and 50s , and decrease after the 50s.
Mean hand grip values were similar : @number@ kg right hand ; @number@ kg left hand.
Mean HAS was higher in men than in women for all age categories.
Mean hearing threshold levels ( @number@ to @number@ Hz ) for both groups were @number@ dB HL or better.
Mean Heidelberg subfoveal CT was @number@ µm.
Mean hospitalization time was @number@ days , @percent@ were polytrauma patients.
Mean hospitalization was longer after procedures complicated by ASC ( @number@.2±1.6 versus @number@.9±1.9 days ; range , 0-7 days ; P = 0.002 ) .
Mean hospital length of stay significantly improved from @number@ to @number@ days ( p = @number@ ) .
Mean hospital stay was @number@ days ( range , 3-32 ) and mean follow-up was @number@ months ( range , 1-48 ) .
Mean HSA indices were determined for each 5-year age group after adjustment for height and weight based on most recent Japanese population values.
Mean HVs correlated with the CSF P-tau level ( R = @number@ ) .
Mean hyperopic refraction was @number@ ( @number@ to @number@ ) dpt , mean myopic refraction was @number@ ( @number@ to @number@ ) dpt.
Mean ILB height was @number@ mm for males and @number@ mm for females.
Mean indwelling time was @number@ ± @number@ days.
Meaningful activities ( leisure , community participation ) were not targeted.
Meaningful calcification was defined as @percent@ or greater.
Meaningful comparisons require larger samples than have frequently been used and should ideally be based upon standardized samples.
Meaning was attached to mealtime changes , observed through emotions experienced and diverse strategies developed to support mealtime values.
Mean inner arterial and venous diameters were @number@ ± @number@ μm and @number@ ± @number@ μm , respectively.
Mean intakes of calcium , magnesium and potassium were all below recommended levels and sodium intakes were above recommendation.
Mean intensity ranged from @number@ ( ±19.8 ) to @number@ ( ±17.3 ) ( subjects aged 30-39 years and 50-65 years , respectively ) .
Mean ISEL score was @number@ which indicated lower social support than population norms.
Mean labial curvature was larger in young men than in the other groups , and it was more variable in young than in old persons.
Mean length of stay was @number@ days with an inpatient and 1-year mortality rate of @number@ and @number@ % , respectively.
Mean level of conus medullaris located in L1 lower @date@ .
Mean levels of IL-8 were compared using a Wilcoxon matched-pairs test.
Mean levels of @number@ to @number@ nmol / l were reached in most RCTs with @number@ to @number@ IU vitamin D per day without risk.
Mean levels of total PrP ( C ) were significantly lower in the CSF from fCJD patients than from those with sCJD or FFI.
Mean LTL at follow-up was measured by multiplex quantitative real-time PCR.
Mean LV ejection fraction was @number@ ± @percent@.
Mean mHAI scores were lower in adults who were younger , non-Hispanic whites , more educated , and married / living with partner.
Mean mitral valve diameter CONCLUSIONS : The detection rate of CoA may improve when a multiple-criteria prediction model is adopted.
Mean MNA-SF score was @number@ ( SD @number@ ) .
Mean MoCA score was @number@ ± @number@ in the entire population.
Mean negative mood scores reduced by @number@ for each year of increasing age.
Mean NFL was thinnest in eyes with larger cup / disc ( C / D ) ratios.
Mean number of chronic drugs per resident was @number@.14±2.60 from @number@.81±2.24 to @number@.95±2.73 ( P < 0.001 ) .
Mean number of filled teeth in the EG was statistically significantly lower than in the CG ( p < 0.001 ) .
Mean ± @number@ standard deviations were respectively 110° to 150° for SSA and 85° to 100° for ST.
Mean nutrient intakes and densities were above recommended intakes for all nutrients examined , except calcium , iron and zinc.
Mean organonchlorine levels were higher in CDV-negative animals indicating that organochlorines did not contribute significantly to CDV mortality in epizootics.
Mean or median days to recovery from delirium and the scale used to measure recovery were identified.
Mean osteon orientation was @number@.1° ( 90° being longitudinal ) .
Mean ovarian SUVs ( @number@ ± @number@ ) were comparable to brain levels and higher than in any other organ.
Mean overall distalization speed was @number@ ± @number@ mm per month.
Mean pack year values were higher in subjects with negative rather than positive hTERT expression in the dermis ( P < @number@ ) .
Mean pain score using visual analog scale was @number@
Mean patient age was @number@ years ( range : @number@.8-61.1 years ) .
Mean patient scores at M01-M03 were significantly higher for HA gel than for saline ( P < 0.05 ) .
Mean PD was @time@ + / -2.39 mm ( range , 10-18 mm ) .
Mean ( @percent@ C.I. )
Mean ( @percent@ confidence interval [ C.I. ] )
Mean plasma level of endothelin-1 has been shown to be significantly higher in Fontan patients compared to healthy controls.
Mean PMT was @number@.98 + / -1.04 mm ( range , @number@.5-6.8 mm ) .
Mean POP quantification was stage III in POP-Q scale.
Mean postoperative stay was similar between groups ; no major complications and no cases of mortality occurred.
Mean postoperative time to extubation and average hospital LOS were shorter with dexmedetomidine-based sedation and met a statistical level of significance.
Mean postvoid residual urine was nearly unchanged over the age groups at approximately 20-30 cc.
Mean QoL scores were compared across demographic , socioeconomic , and clinical variables using analysis of variance , t test , and regression analysis.
Mean QT dispersion ( QTd ) was paradoxically less in the UCP2 DD genotype compared to UCP2 II subgroup ( p = 0.034 ) .
Mean quantitative grade of all pathologic findings were also calculated according to Brunt scoring values.
Mean Quick-DASH was @number@ ± @number@
Mean range of motion ( ROM ) was @date@ .9° / 128.2°.
Mean rate of population doubling was lower in elderly donor cells compared to those from young adult cells ( P < @number@ ) .
Mean retinal sensitivity and thickness were calculated for @number@ healthy eyes ( mean age , @number@ ± @number@ years ) .
Mean retreatment volume was less than @percent@ of the initial treatment volume.
Mean risk perception at baseline was @number@ %.
Mean RNFL thickness decreased by approximately @number@ µm per year of aging life , and by @number@ µm for each 1-mm of axial elongation.
Mean robotic guidance took @number@ minutes.
Mean score of the UCLA-LS was determined as @number@ ± @number@
Mean ( ±S.D. )
Mean ( SD ) age was @number@ ( @number@ ) years and @number@ ( @percent@ ) were females.
Mean ( SD ) age was @number@ ( @number@ ) years , @percent@ of the participants were cognitively impaired , and @percent@ had cancer.
Mean ( SD ) BMI was @number@ ( @number@ ) kg / m2 , and functional status @number@ ( @number@ ) .
Mean ( SD ) follow-up was 10 ( @number@ ) years , @number@ deaths occurred.
Mean ( SD ) plasma esRAGE was @number@ ( @number@ ) ng / ml.
Mean ( SD ) thickness in quiet stance was @number@ cm.
Mean ( ±SD ) TTR was @number@ ± @number@ %.
Mean sensory nerve action potential ( SNAP ) amplitude of MN from second finger was also not different between two genders.
Mean serum 25 ( OH ) D was @number@ ± @time@ standard deviation ( SD ) ng / mL.
Mean serum cystatin C levels were significantly higher ( @number@ vs. @number@ mg / l ; p = @number@ ) in the ELBW group.
Mean serum testosterone level was @number@ ± @number@ ( SD ) ng / dL.
Mean SF-36 MH scores at @number@ months differed by @number@ points ( @number@ CI : @number@ to @number@ P = @number@ ) after adjustments.
Mean sitting and walking time per day were @number@.3±1.4 and @number@.8±0.9 h / d , respectively.
Mean sphere in WTR , ATR , and oblique astigmatism was @number@ @number@ and @number@ D , respectively ( p < @number@ ) .
Mean spherical equivalent was @number@ ± @number@ diopters ( D ) ( range , @number@ to @number@ D ) .
Mean spironolactone dose was @number@ ± @number@ mg / d and was well tolerated.
Mean SSA and ST were higher in females but by less than 2°.
Mean , standard deviation , compound symmetry covariance , analysis of variance , and analysis of covariance were used for statistical analysis.
Mean [ ± standard deviation ( SD ) ] age was @number@ ± @number@ years and @number@ % were women.
Mean ( standard deviation ) total T ( ng / dL ) was @number@ ( @number@ ) .
Mean STL was significantly lower among children with PTE ( @number@ vs @number@ P < @number@ ) .
Mean stone size was similar in groups ( @number@ ± @number@ vs. @number@ ± @number@ mm , p = @number@ ) .
Mean subfoveal choroidal thickness ( SFCT ) was 282±49μm.
Mean subfoveal CT was @number@ µm thinner by Heidelberg versus Cirrus ( P < @number@ ) .
Mean SUV between genders for all groups were also compared.
Mean SUVs were higher in men than in women , and brain uptake was blocked by letrozole.
Means were compared with T-tests stratified on gender , age-groups and educational level.
Mean Sydney Centenarian Study Hannum age acceleration was negative , while the converse was observed for the Horvath model.
Mean %TBSA was @number@ ± @percent@ and mean frailty score ( FS ) was @number@ ± @number@
Mean telomere length decreased with decreasing distance to the central weight-bearing area , however , unexpectedly increased in the most central zone.
Mean telomere length was significantly shorter in the transplant group ( @number@.59±0.6 vs. @number@.91±1.78 in the controls , p < 0.0001 ) .
Mean telomere length was significantly shorter with more extensive coronary calcification.
Mean time elapsed since the diagnosis of arterial hypertension was @number@ years.
Mean time since first TBI was @number@ ± @number@ y.
Mean time since Fontan completion was @number@ ± @number@ years ( range @number@ to @number@ years ) .
Meantime we propose to evaluate an easy and well accepted treatment based on a weekly quasi-total body exposure to oxygen-ozone inside a thermostatically controlled cabinet.
Mean total brain lipid , phospholipid , cholesterol , and triglyceride concentrations did not differ significantly between AD and controls.
Mean total Female Sexual Function Index was low ( M = @number@ SD = @number@ ) .
Mean total hippocampal atrophy for the entire sample was @percent@ per year ( @percent@ CI @number@ @number@ ) .
Mean TPR during HUT increased with age ( p = @number@ ) , particularly in older women.
Mean TT level was @number@ ranging from @number@ to @number@ ng / ml.
Mean tumor volume was @number@ cm.
Mean values for vHIT gain were higher for head technique.
Mean values of score were of @number@ for the CCI , @number@ for the CIRS-G and @number@ for the MDBI.
Mean values , standard deviation , chi-square test , t-test and p values were used to obtain inter-group comparisons.
Mean values / tubule , case and AgGr were calculated for each parameter.
Mean values were compared using Student's t test for normally distributed data or Mann Whitney U-test when non-normally distributed.
Mean values were statistically analyzed using one-way analysis of variance ( ANOVA ) , with p < @number@ as significance level.
Mean values were statistically analyzed with one-way analysis of variance ( ANOVA ) , followed by Tukey test with p < @number@ as significance level.
Mean velocity values were higher for chin technique and lower velocities were observed in the older age group.
Mean viral load was undetectable in @number@ patients and unavailable in five.
Mean VO2 was @number@ ± @number@ ( % of VO2max ) and VO2peak @number@ ± @number@ ( % of VO2max ) .
Mean volume fraction of total ventricle volume to total brain volume was found to be @percent@ in the first and @percent@ in the last decades.
Mean volume fraction was found to increase significantly with age ( p < @number@ r = @number@ Pearson ) .
Mean volume injected was @number@ ± @number@ mL for both NLFs combined.
Meanwhile , age per sec is an unfavorable determinant that has an impact on liver-related outcomes.
Meanwhile , a growing body of evidence is suggesting that exposure to insecticides can also potentiate the risk of obesity and type @number@ diabetes.
Meanwhile , a short battery of physical performance tests was conducted to assess the balance , mobility , and flexibility among elderly people.
Meanwhile , berberine has drawn increasing attention to its antineoplastic effect in recent years.
Meanwhile , both angiogenesis and revascularization were increased , while the extended inflammatory reaction was repressed in the relaxin-treated injured muscle.
Meanwhile , care standards and government policies have emphasized the need for preparing students to care for the older people.
Meanwhile , CIA is treated by apoptosis inhibitors , cytokines and topical immunotherapy.
Meanwhile , current assessment instruments are underused , lack sensitivity , or may be restricted by copyright laws.
Meanwhile , enhanced presence of immunoproteasomes in ageing brain and muscle tissue could reflect a persistent inflammatory defence and anti-stress mechanism.
Meanwhile , females demonstrated prolonged modulating effect of peptide on the proliferation.
Meanwhile , formulated foods with peanuts as a major ingredient are being promoted to prevent and control malnutrition in developing countries.
Meanwhile , insignificant between-group difference in rehabilitation outcomes was observed.
Meanwhile , MCL markedly promoted antioxidant protein heme oxygenase-1 ( HO-1 ) expression by enhancing NF-E2-related factor @number@ ( Nrf2 ) activity.
Meanwhile , miRNA also involved in various stages of skin regeneration and wound healing.
Meanwhile , near visual acuity and cognition also showed unique environmental correlation , r E = @number@ [ @percent@ CI : @number@ @number@ ] .
Meanwhile , @number@ matched non-PD patients were selected based on age , sex , and body mass index.
Meanwhile , numerous interconnections have become apparent between age-dependent changes previously thought to proceed more or less independently.
Meanwhile , OPRM1 CpG1 hypermethylation and CpG2-4 hypomethylation were associated with MCI risk in Xinjiang Uygur and Han , respectively.
Meanwhile , pharmacologic interventions and hormonal perturbations have increased the life span of several mammalian species without necessarily addressing features of age-related metabolic decline.
Meanwhile , pneumococcal conjugate vaccine is allowed for administration in adults but is not recommended by STIKO yet.
Meanwhile , prevention of DHF through appropriate and aggressive risk factor identification and management must remain the cornerstone of clinical intervention.
Meanwhile , primary care commissioners in the UK are establishing new frailty care pathways and developing frailty registers in primary care.
Meanwhile , RORα and its target gene expressions are lower in human colorectal tumor tissue compared with control colorectal tissue.
Meanwhile , several solutions have been developed that address how to build a smart home environment in order to create an ambient assisted environment.
Meanwhile , the higher educational level of Chinese compared to whites provided them with no protection from adverse exposures.
Meanwhile , the level of SIRT1 activity was down-regulated.
Meanwhile , the number of hay fever patients in Japan is increasing , causing an increase in national medical expenses.
Meanwhile , the number of persons with HIV / AIDS leaving correctional facilities remains virtually identical.
Meanwhile , the other half served as a control group with younger ages.
Meanwhile , the prevalence among men / women and urban / rural areas was significantly different.
Meanwhile , the recent development of effective techniques to study adult cardiac performance in the fly has opened new uses for the Drosophila model system.
Meanwhile , there has been increasing appreciation of direct involvement of myofibroblasts , the activated form of fibroblasts , in arrhythmogenesis.
Meanwhile , the score of OSDI in dry eye patients was significantly higher than that in non-dry eye individuals.
Meanwhile , these brain activity changes might be used as a useful clinical indicator for MB.
Meanwhile , the significant increase in salivary α-amylase activity after walking might temporarily cause deterioration of executive function.
Meanwhile , the SNP was able to affect expression of ATM mRNA by differentially binding to AP-2α.
Meanwhile , this modulation was dependent on DAP12 , the adapter protein of TREM2.
Meanwhile , TP receptor antagonism may emerge as a therapeutic alternative to reverse prostanoid-mediated vascular dysregulations.
Meanwhile , USP14 knockdown by siRNA showed the same effects , with no cytotoxicity in THP-1 cells.
Meanwhile , we took photos of their dorsal hands.
Mean γ-tocopherol did not change appreciably throughout the year after fracture , although it fluctuated widely within individuals.
Measured alterations were confirmed with RT-PCR both on dependent and independent sample sets ( n1 = @number@ n2 = @number@ n3 = @number@ ) .
Measured by texture , the experimental group had better results on weeks @number@ @number@ @number@ @number@ @number@ and @number@
Measured continuously , physical activity improved survival ( HR = @number@ @percent@ CI = @number@.41-0.66 , P < @number@ ) .
Measured genetic risk accounts for only a small amount of total variation in BMI among white and black young adults.
Measured parameters were analyzed at each timepoint.
Measured physical performance is closely tied with socioeconomic conditions , but self-reported measures have a much smaller or weaker socioeconomic gradient.
Measured somatic and psychological characteristics explained @percent@ of the covariance between pain and depressive symptoms over time.
MEASUREMENT AND RESULTS : Sleep stages were identified by in-home polysomnography at the initial sleep visit ( 2003-2005 ) .
MEASUREMENT : A panel of @number@ SASP-related proteins was extracted from a previous multiplex protein panel performed in these participants.
Measurement bias ( accuracy ) and dispersion ( precision ) were evaluated , together with intra- and inter-scan repeatability.
MEASUREMENT : Diet was assessed using a 142-item food frequency questionnaire at baseline.
MEASUREMENT : Flow-mediated dilation of brachial artery ( FMD ) and intima-media thickness ( IMT ) of carotid artery were measured by ultrasound.
MEASUREMENT : Inpatients ' characteristics were obtained through a comprehensive geriatric assessment of inpatients , conducted in the first week of hospitalization.
Measurement invariance was investigated as a function of family history of AD and apolipoprotein E ( APOE ) status.
MEASUREMENT : Nutrient content of the served food and real food consumption was calculated for all meals during a 5-day period by precise weighting method.
Measurement of bone mass , geometry , density , and strength are critical in bone research and clinical studies.
Measurement of cutaneous resonance running time ( CRRT ) is a method to assess skin elasticity.
Measurement of fibula and ulna bone length could be an alternative method.
Measurement of forniceal foreshortening facilitates monitoring of these disorders.
Measurement of hip strength may therefore be a useful screening tool to detect those at risk of functional decline and requirement for additional care.
Measurement of MMG signal during voluntary isometric contraction of the biceps brachii muscle was conducted to confirm whether PVDF film can detect MMG signal.
Measurement of PA must be valid and reliable ; however , the degree to which studies employ valid and reliable measures of PA is unclear.
Measurement of sc- @time@ may add relevant information in the assessment of fracture risk.
Measurement of serum alanine aminotransferase ( ALT ) is a common , readily available , and inexpensive laboratory assay in clinical practice.
Measurement of testosterone levels might be considered in men @number@ years or older who have unexplained anemia and symptoms of low testosterone levels.
Measurement of these values may aid in the evaluation of treatment options and preoperative planning.
Measurement of volume flow rates in major cerebral vessels can be used to evaluate the hemodynamic effects of cerebrovascular disease.
MEASUREMENT : Omega-3 PUFA supplements intake and Mini-Mental State Examination ( MMSE ) were assessed at baseline.
MEASUREMENT : Regional gray matter volumes were segmented automatically in all subjects and evaluated in relation to age , using high-resolution MRIs at @number@ Tesla.
Measurement results from healthy young and middle age individuals should not be used for the assessment of individuals older than @number@ years of age.
Measurements.
MEASUREMENTS : A cross-sectional pQCT scan of the non-dominant lower leg was acquired to determine muscle density and area.
MEASUREMENTS : Adherence to the MD was evaluated with an a priori score based on the Mediterranean pyramid components.
MEASUREMENTS : A dietetic study undertaken using the precise weighing method ( @number@ consecutive days ) .
MEASUREMENTS : age , gender , level of education , environment , cognitive status , physical impairment , diseases , health perception and social support.
MEASUREMENTS : A global composite score averaging @number@ tests of global cognition , verbal memory , and category fluency.
MEASUREMENTS : A group-based trajectory model was used to determine BMI trajectories , the path a person's BMI followed over @number@ years.
MEASUREMENTS : Alcohol-related assessments at baseline and @number@ months ; CARET-assessed at-risk drinking , number of risks , and types of risks.
MEASUREMENTS : Alcohol use was assessed with the Alcohol Use Disorders Identification Test ( AUDIT ) .
MEASUREMENTS : All-cause mortality.
MEASUREMENTS : all frailty data collected routinely as part of a CGA were used to create the FI-CGA.
MEASUREMENTS : All participants completed an Arthritis Impact Measurement Scale ( AIMS2 ) pre- , mid- and post- study period.
MEASUREMENTS : All participants underwent baseline assessment of purpose in life and detailed annual clinical evaluations to document incident disability.
MEASUREMENTS : All participants underwent baseline cognitive testing and annual mobility examinations.
MEASUREMENTS : All participants underwent TCD assessments and tests of lower extremity function at an annual clinic visit.
MEASUREMENTS : All subjects underwent clinical , biological examinations.
MEASUREMENTS : ALM was quantified using bioimpedance analysis.
MEASUREMENTS AND MAIN RESULTS : A total of @number@ patients were maintained on mechanical ventilators for @number@ days.
MEASUREMENTS AND MAIN RESULTS : A total of @number@ ( @percent@ ) patients died in the hospital.
MEASUREMENTS AND MAIN RESULTS : Discharge disposition , hospital length of stay , and national cost ( adjusted to @number@ dollars ) were examined.
MEASUREMENTS AND MAIN RESULTS : EPPE mice develop increased total lung phospholipid , followed by a macrophage-predominant pulmonary inflammation , and lung remodeling including fibrosis.
MEASUREMENTS AND MAIN RESULTS : In the case-control analysis , @number@ SNPs were significant at P ≤ @number@
MEASUREMENTS AND MAIN RESULTS : Menopausal status was associated with accelerated lung function decline.
MEASUREMENTS AND MAIN RESULTS : Mitochondrial respiration was measured in permeabilized muscle fibers with high-resolution respirometry.
MEASUREMENTS AND MAIN RESULTS : Multiple environmental barriers to sleep in the ICU were identified when participants were directly asked about factors affecting sleep.
MEASUREMENTS AND MAIN RESULTS : Patients received the Confusion Assessment Method for the ICU , Richmond Agitation-Sedation Scale , and Delirium Rating Scale-Revised-98 assessments.
MEASUREMENTS AND MAIN RESULTS : Sepsis patients admitted to the ICU were more frequently males ( @percent@ ; p < @number@ vs females ) .
MEASUREMENTS AND MAIN RESULTS : Subjects had few symptoms , that is , sleepiness , depression , anxiety , and cognitive deficits.
MEASUREMENTS AND RESULTS : Brachial cuff arterial blood pressure and heart rate were measured in semi-recumbent and upright positions.
MEASUREMENTS AND RESULTS : Major depression at year @number@ defined by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders.
MEASUREMENTS AND RESULTS : SDB was defined as an apnea-hypopnea index ( AHI ) > or = @number@ events / hour of sleep.
MEASUREMENTS AND RESULTS : Sleep disturbance was evaluated by the Leeds Sleep Evaluation Questionnaire.
MEASUREMENTS AND RESULTS : Spectral analysis was performed on artifact-free NREM sleep epochs ( C3 / A2 ) .
MEASUREMENTS AND RESULTS : There were no significant differences between treatment groups in sleep outcomes at @number@ mo.
MEASUREMENTS AND RESULTS : We found that patients with CI experienced increased UDP changes relative to controls.
MEASUREMENTS : An initial set of @number@ items rated on a 5-point Likert scale of agreement was reduced using principal components analysis.
MEASUREMENTS : An in-vehicle monitoring device hardwired into participants ' vehicles measured driving exposure.
MEASUREMENTS : Annually collected serum was assayed for E2 and FSH levels.
MEASUREMENTS : Anthropometric measurements and biochemical analyses of fasting blood samples were performed by standardized methods.
MEASUREMENTS : Anthropometric measurements , handgrip strength , physical performance tests , and ( DXA ) scan were performed.
MEASUREMENTS : APOE genotype and mortality based on National Death Index.
MEASUREMENTS : A questionnaire was used to obtain information on lifestyle , including education , living conditions , and physical activity.
MEASUREMENTS : a regression model was used to construct risk-adjusted rates of in-hospital deaths considering the facilities ' characteristics.
MEASUREMENTS : A semi-quantitative , interviewer-administered , 108-item food frequency questionnaire designed to estimate dietary intake.
MEASUREMENTS : Assessment of target-patient prescriptions and direct observation of nurses ' medical rounds.
MEASUREMENTS : Assessments were conducted by trained research assistants using structured questionnaires at baseline , @number@ months , and @number@ year after baseline.
MEASUREMENTS : Association between mortality and cardiac drugs , adjusted for sociodemographics , co-morbidity and propensity to receive cardiac drugs.
MEASUREMENTS : A standard Brazilian version of the MMSE.
MEASUREMENTS : At baseline , data on demographic characteristics , CRFs , other lifestyle factors , C-reactive protein , and cognitive function were collected.
MEASUREMENTS : At baseline , @number@ and @number@ months , self-reported Food Frequency Questionnaires ( FFQ ) and demographics were collected and anthropometry measured.
MEASUREMENTS : At baseline , nutritional status was assessed with the MNA-SF.
MEASUREMENTS : A telephone survey of hospice and PC providers followed by an online survey of programs providing nonhospice PC.
MEASUREMENTS : A trained researcher translated the FAM-CAM according to International Society For Pharmacoeconomics and Outcomes Research guidelines.
MEASUREMENTS : Based on EWGSOP diagnostic criteria subjects were classified as sarcopenic and non-sarcopenic.
MEASUREMENTS : Baseline ABI and interviewer- and computer-administered cognitive function assessments were obtained.
MEASUREMENTS : Baseline data collection included c-reactive protein ( CRP ) and interleukin-6 from blood draws , anthropometric measures , and numerous questionnaires.
MEASUREMENTS : Baseline total , animal and vegetable protein intakes were collected using a validated food frequency questionnaire.
MEASUREMENTS : Benzodiazepine users were separated into hypnotic , short-acting anxiolytic , and long-acting anxiolytic users and compared with non users.
MEASUREMENTS : Blood and stool samples were collected on days @number@ and @number@
MEASUREMENTS : Blood glucose was analyzed prior to consuming the test food , at @number@ @number@ @number@ @number@ @number@ and @number@ minutes after food consumption.
MEASUREMENTS : BMI was calculated based on self-reported height and weight.
MEASUREMENTS : BMI , WC and covariates were measured at baseline in 2004-2005.
MEASUREMENTS : Body mass indexes were calculated from weight ( kg ) divided by the square of height ( m ) .
MEASUREMENTS : Body weight , height and body mass index were evaluated in each subject.
MEASUREMENTS : Both cohorts reported any recent drinking and average number of drinks per drinking day using similar but not identical questions.
MEASUREMENTS : Both studies gathered self-reported data on physical and mental health , behavioral health , functional limitations , and health-care utilization.
MEASUREMENTS : Caregiver burden ( emotional , physical , financial difficulties ) and restrictions on social participation.
MEASUREMENTS : Cause of death and demographic data as recorded on death certificates.
MEASUREMENTS : CBV , quantitative transverse relaxation time ( T2 ) maps , and cortical thickness were measured by magnetic resonance imaging.
MEASUREMENTS : Characteristics of the POLST conversation were assessed.
MEASUREMENTS : Chart data from a random sample of @number@ antibiotic prescriptions for SSTIs were abstracted.
MEASUREMENTS : Chronic medical comorbidity , medications , and inpatient and outpatient healthcare utilization extracted from Danish healthcare registers.
MEASUREMENTS : Clinical diagnoses before SPECT were compared with imaging results.
MEASUREMENTS : Clinicians and staff evaluated each participant's dementia status during annual in-person assessments.
MEASUREMENTS : Cognitive ability was assessed using the Wechsler Adult Intelligence Scale at age @number@ or @number@
MEASUREMENTS : Cognitive functioning across six subdomains was assessed using the Cognitive Telephone Screening Instrument.
MEASUREMENTS : Cognitive function was assessed by Mini-Mental State Examination ( MMSE ) .
MEASUREMENTS : Cognitive performance was assessed according to @number@ neuropsychological indices and the Clinical Dementia Rating Sum of Boxes ( CDR-SOB ) .
MEASUREMENTS : Columbia University Scale for Psychopathology , modified Mini-Mental State Examination , and Dependence Scale.
MEASUREMENTS : Comprehensive geriatric assessment was done for every participant to evaluate medical , functional , cognitive and affective aspects.
MEASUREMENTS : Comprehensive geriatric assessment was performed and nutritional status was assessed by the Mini Nutritional Assessment Short Form ( MNA-SF ) .
MEASUREMENTS : Comprehensive health assessments were undertaken.
MEASUREMENTS : Conjoint analysis was applied to measure participants ' preferences for long-term care facility services.
MEASUREMENTS : Daily 24-hour pedometer / accelerometer data , collected continuously for @number@ years , were categorized into activity quartiles.
MEASUREMENTS : Daily 24-h pedometer / accelerometer data were collected continuously for @number@ years.
MEASUREMENTS : Data on satisfaction and problems regarding the meal service were collected by structured interviews.
MEASUREMENTS : Data was collected from a stratified sample of @number@ residential aged care facilities in each state and territory in Australia.
MEASUREMENTS : Data were collected at baseline and quarterly for up to @number@ months.
MEASUREMENTS : data were collected by means of a modified validated dietary history , both at baseline and then @number@ y later.
MEASUREMENTS : Data were collected from patients using baseline , 6- and 12-month mail surveys.
MEASUREMENTS : Data were collected through interviews , clinical examinations , and psychological testing , following a standard procedure.
MEASUREMENTS : Delirium was evaluated with the Confusion Assessment Method for the Intensive Care Unit and cognitive outcomes were tested at @number@ and 12-month follow-up.
MEASUREMENTS : Dementia predating rehabilitation admission was detected by DSM-III-R criteria.
MEASUREMENTS : Demographic and clinical data were collected.
MEASUREMENTS : Demographic characteristics , medical history , Geriatric Depression Scale , Blessed Test , Total Pain Index , gait velocity.
MEASUREMENTS : Depression and disability were measured with Hamilton Depression Rating Scale-24 items and Sheehan Disability Scale , respectively.
MEASUREMENTS : Depression diagnoses and psychotherapy use identified from Medicare claims ; antidepressant use identified from detailed medication inventories conducted by interviewers.
MEASUREMENTS : Depressive symptoms measured using the 15-item Geriatric Depression Scale.
MEASUREMENTS : Depressive symptoms were assessed using the CES-D.
MEASUREMENTS : Descriptive statistics were calculated for utilization measures for each type of provider and by location of care.
MEASUREMENTS : Diagnosis of dementia before nursing home admission.
MEASUREMENTS : Dietary habits was investigated through a 3-day record questionnaire.
MEASUREMENTS : Dietary intake of @number@ nutrients associated with cognitive function and AD was assessed using the Harvard / Willet Food Frequency Questionnaire.
MEASUREMENTS : Dietary intake was assessed using validated Food Frequency Questionnaires at baseline ( 1990-1994 ) and follow-up ( 2010-2011 ) .
MEASUREMENTS : Dietary intake was measured using weighed food records and food diaries , comparing females and males.
MEASUREMENTS : Dietary TAC and food intakes were calculated using a validated brief-type self-administered diet history questionnaire.
MEASUREMENTS : Dietary variety was assessed using a 10-item food frequency questionnaire.
MEASUREMENTS : Direct question about hearing loss , indirect question , finger-rub test , whisper test , and audiometric results using a hand-held audiometer.
MEASUREMENTS : DNA was obtained via blood samples.
MEASUREMENTS : During a @number@ year follow-up , women were contacted by telephone every @number@ months to investigate the occurrence of falls.
MEASUREMENTS : Dysglycemia categories were based on HBA1c or history of type @number@ diabetes ( diabetes ) .
MEASUREMENTS : Each patient was submitted to a standardized evaluation including clinical investigation , cerebral imagery , and neuropsychological assessment.
MEASUREMENTS : Energy intake was calculated for each subject with the CIT and by weighing the food consumed.
MEASUREMENT : Serum levels of TGF beta and soluble endoglin were measured by the ELISA method in samples of peripheral blood using commercial kits.
MEASUREMENTS : Ethnic group was classified using a validated algorithm.
MEASUREMENTS : Falls history was collected retrospectively at baseline in each study.
MEASUREMENTS : Family reported on quality of feeding care at enrollment and @number@ months.
MEASUREMENTS : First , we qualitative analysed the Integrated Care Program taking as dimensions eight facilitators towards integrated care.
MEASUREMENTS : Five visits ( w-4 , w0 , w6 , w10 and w18 ) .
MEASUREMENTS : Fleiss ' κ values and the intraclass correlation coefficient were calculated for inter-rater reliability.
MEASUREMENTS : Focus group transcripts were transcribed and analyzed using methods of grounded theory.
MEASUREMENTS : FoF was assessed at baseline using the Falls Efficacy Scale International ( FES-I ) and three questions previously validated.
MEASUREMENTS : Following informed consent , a complete clinical examination was performed upon recruitment , and the primary caregiver was interviewed.
MEASUREMENTS : Food intake was assessed by a 4-day weighed-food record.
Measurements for female SPs were smaller , but the slope was steeper.
MEASUREMENTS : Four years of nutritional risk SCREEN II scores ( five waves ) from the male survivors of the MFUS cohort.
MEASUREMENTS : Frailty was assessed according to the frailty phenotype , described by Fried et al.
MEASUREMENTS : Frailty was defined according to a set of criteria derived from a definition previously described and validated.
MEASUREMENTS : Frailty was determined using modified Fried's criteria.
MEASUREMENTS : Frailty was first assessed using a 32-item FI ( FI-32 ) .
MEASUREMENTS : Frailty was operationalized using three frailty indices ( FI-lab , FI-self-report , FI-combined ) and the frailty phenotype.
MEASUREMENTS : Frailty was quantified using the deficit accumulation-based frailty index ( FI ) , constructed from @number@ health deficits at baseline.
MEASUREMENTS : From @number@ to @number@ participants were queried on type , frequency and location of physical activity.
MEASUREMENTS : Fruit , vegetable and fish intake was assessed using a short food frequency questionnaire.
MEASUREMENTS : FSRP , CAIDE risk score , oxi-inflammatory load , FSRP incorporating oxi-inflammatory load , and CAIDE risk score incorporating oxi-inflammatory load.
MEASUREMENTS : Functional disability was defined as difficulty with activities of daily living : taking a bath or walking @number@ to @number@ m.
MEASUREMENTS : Function , based on self-reported difficulty in performing ADLs and IADLs , and cognition , using the MMSE.
MEASUREMENTS : FVA measurements , Schirmer test , BUT , tear clearance rate and fluorescein vital staining scores were obtained.
MEASUREMENTS : Gait speed , activity , disability , cognition , overall health , 5-year mortality.
MEASUREMENTS : Gait speed , cognitive function ( 3MSE score ) , APOE4 , HTN , BMI , education , health status.
MEASUREMENTS : Gait speed was measured on a straight 6-m course and averaged over two trials.
MEASUREMENTS : General linear regression model estimates assessed associations between depressive symptom change and functional status @number@ and @number@ months after discharge.
MEASUREMENTS : GPs assessed the cognitive status of their patients on the Global Deterioration Scale ( GDS ) .
MEASUREMENTS : Habitual F & V intakes were ascertained from a validated food frequency questionnaire.
MEASUREMENTS : Hearing impairment was defined as poor self-reported hearing.
MEASUREMENTS : Height , weight , waist circumference , blood pressure measurements were taken according to standardised HSE protocols.
MEASUREMENTS : Hospice referral was defined as referral to hospice within @number@ day after hospital discharge.
MEASUREMENTS : Hospitalizations were reported at annual clinic visits and in semiannual phone interviews.
MEASUREMENTS : Hospital LOS.
MEASUREMENTS : HRs contrasting CKD risk across arsenic exposure levels were estimated using Cox regression.
MEASUREMENTS : Incidence of dementia , its subtypes , and all-cause mortality.
Measurements included IOP , ocular biometrics and AHD.
Measurements included responses to the Patient Health Questionnaire-9 , financial strain , and age.
Measurements included self-rated health , the number of chronic conditions , the Short Form-20 , the Eysenck Personality Questionnaire and Social support.
MEASUREMENTS : Individual behavior problems were measured with the Memory and Behavior Problem Checklist.
MEASUREMENTS : Individual sociodemographic characteristics were obtained from Florida's Medicaid comprehensive assessment data.
MEASUREMENTS : Information on number of deaths and causes of mortality was obtained from death certificates.
MEASUREMENTS : Information on readmissions to hospital and mortality at @number@ and @number@ days after discharge was obtained from electronic patient records.
MEASUREMENTS : Information on sociodemographic characteristics , health , cognition , and functional ability was collected in an interview.
Measurements in infants indicated that the screening performance of BC-TEOAEs and AC-TEOAEs may be comparable.
MEASUREMENTS : In @number@ and @number@ @number@ White and @number@ Black older women were queried on diet using both FFQ and 24-hour recalls.
MEASUREMENTS : In study @number@ participants had barriers experienced at one mealtime assessed with MAT.
MEASUREMENTS : Intervention costs were assessed.
MEASUREMENTS : Interviewer-assisted questionnaires to assess physical activity , health status , and mood were administered.
MEASUREMENTS : Intra-erythrocyte magnesium levels were analyzed with atomic absorption spectrophotometry.
MEASUREMENTS : Laboratory measurements , cognitive functioning , and depressive symptoms were assessed at baseline , @number@ and @number@ years follow-ups.
MEASUREMENTS : Length of stay ( LOS ) , weight change and frequency of readmission to hospital were compared between the groups.
MEASUREMENTS : Life-space mobility was evaluated by telephone every @number@ months for up to @number@ years using the previously validated Life-Space Assessment.
MEASUREMENTS : Light , moderate , and vigorous physical activities in mid- and late life were assessed using a validated questionnaire.
MEASUREMENTS : Long-term DASH adherence was calculated as the average DASH adherence score from up to @number@ repeated measures of diet.
MEASUREMENTS : Main measurements were baseline standing height and 11-year follow-up and knee-estimated height in follow-up.
MEASUREMENTS : Main outcomes were SPPB score and gait speed.
MEASUREMENTS : Main outcome was self-reported functional difficulty level for @number@ basic activities.
MEASUREMENTS : Malnutrition and obesity were evaluated to assess the nutritional status.
MEASUREMENTS : MD was self-reported ; Cox regression was used to assess the association between self-reported MD and 9-year all-cause mortality.
MEASUREMENTS : MEASUREMENTS included rating scales regarding malnutrition risk ( SCREEN II ) and risk of falling ( Downton ) .
MEASUREMENTS : Medline ( PubMed ) , AMED , Psych INFO , and Cochrane Central databases were searched for articles until @date@ .
MEASUREMENTS : Memory , executive function and processing speed were assessed at baseline and at 6- and 12-year follow-up.
MEASUREMENTS : Metabolic syndrome ( U.S. National Cholesterol Education Program definition ) and its individual components were assessed as well as serum @number@ OHD levels.
MEASUREMENTS : MetS was defined according to the National Cholesterol Education Program ( NCEP ) Adult Treatment Panel III ( ATP III ) criteria.
MEASUREMENTS : MetS was defined according to the @number@ multiagency harmonized criteria.
MEASUREMENTS : MetS was determined according to the Adult Treatment Panel III of the National Cholesterol Education Program ( ATP III ) criteria.
MEASUREMENTS : Minimum Data Set ( MDS ) @number@ admission assessments identified delirium based upon Confusion Assessment Method ( CAM ) items.
MEASUREMENTS : Mixed-effects linear regression models were used to determine the association between time-varying PA and change in each PPM.
MEASUREMENTS : Mixed models were used to assess the association between the COMT genotype and 6-m walk time , cross-sectionally and longitudinally over @number@ years.
MEASUREMENTS : Mobility limitation was defined as difficulty walking @number@ km or climbing stairs.
MEASUREMENTS : Monthly total Medicare expenditures served as the dependent variable.
MEASUREMENTS : Mortality data were determined from informant contacts and confirmed using the National Death Index and Social Security Death Index.
MEASUREMENTS : Multimorbidity was measured as number of diagnosed diseases.
MEASUREMENTS : Multistage clinical assessment procedures were used to identify incident cases of AD.
MEASUREMENTS : Multivariable propensity score for statin use with greedy matching ( 1 : 1 ) to minimize confounding by indication.
MEASUREMENTS : Muscle strength , physical function , and physical performance.
MEASUREMENTS : Muscle weakness was assessed with a hand-held dynamometer and was normalized to body weight ( normalized grip strength ) .
MEASUREMENTS : Nail selenium levels were measured in all subjects at baseline.
MEASUREMENTS : Neighborhood disadvantage was measured using a composite index derived from baseline neighborhood-level residential census tract socioeconomic variables.
MEASUREMENTS : NIA's grant portfolio was queried for the period @number@ to @number@ using a variety of search terms related to MOCs.
MEASUREMENTS : NLS and STOHFLA were simultaneously given to the patients.
MEASUREMENTS : @number@ items that best operationalized the @number@ CAM diagnostic features were identified to create the 3D-CAM.
MEASUREMENTS : Nutritional and ability status were examined using the MNA and the Barthel Index ( BI ) .
MEASUREMENTS : Nutritional status was assessed by the Mini Nutritional Assessment before and @number@ @number@ @number@ @number@ months after hospital discharge.
MEASUREMENTS : Nutritional status was assessed using BMI and MNA and the association of those two variables with five-year mortality was analyzed.
MEASUREMENTS : Nutritional status was examined by administering the Mini Nutritional Assessment ( MNA ) .
MEASUREMENTS : Nutritional status was measured by MNA at baseline and after @number@ months.
MEASUREMENTS : Nutrition risk was assessed using SCREEN II.
MEASUREMENTS : Objectively measured cognitive abilities and self-reported and performance-based measures of everyday function.
Measurements of blood pressure , blood lactate and stress and anxiety levels were taken before and after sessions.
Measurements of body composition were assessed by dual energy X-ray absorptiometry.
Measurements of brain morphology ( regional tissue volumes and cortical thickness and surface area ) were derived using Freesurfer.
Measurements of cost and outcome ( applied to groups ) are supplanting individuals ' preferences.
Measurements of external and internal anal sphincter pressure at rest , during voluntary contraction and during rectal balloon distension were compared..
Measurements of long-term synthesis rates provide important insights into aging and exercise adaptations.
Measurements of neuron specific enolase messenger ribonucleic acid ( mRNA ) and protein were used to adjust for neuronal loss.
Measurements of oxygen consumption by the mitochondria in human skeletal muscle are used in many studies.
Measurements of skin elasticity were made in three or four sites within eye area.
Measurements of the body stability were made in free standing position , with eyes open and eyes closed.
Measurements of the lumbar multifidus and erector spinae muscles were obtained from T2-weighted axial images at L3-L4 and L5-S1 at baseline and 15-yr follow-up.
Measurements of variation are of great importance for studying the stability of pathological phenomena and processes.
MEASUREMENTS : OHL was defined when the examiner observed it or according to self-reported hearing aid use.
Measurements on @number@ nail samples are carried out and @number@ key species are identified.
MEASUREMENTS : ONS intake was recorded daily and compliance calculated.
MEASUREMENTS : Our main outcome measure is loneliness , which was assessed by four items extracted from the ULCA loneliness scale.
MEASUREMENTS : Outcome measures included self-reporting of dizziness as a symptom experienced either very frequently or continuously during the last month.
MEASUREMENTS : Outcomes were mortality , cardiovascular events , and fragility fractures.
MEASUREMENTS : Pain intensity was measured using an 11-point visual numeric scale.
MEASUREMENTS : PARTICIPANTS attended a physical examination in 1998-2000 , and completed a general questionnaire and a food frequency questionnaire.
MEASUREMENTS : Participants completed an extensive questionnaire covering functional activities and illnesses.
MEASUREMENTS : Participants completed an in-home interview about their OHRQoL and LSM.
MEASUREMENTS : Participants completed a structured interview on demographics and medical history and an HUI questionnaire ( version @number@ ) .
MEASUREMENTS : Participants completed two to six research visits at approximately 4-year intervals between @number@ and @number@
MEASUREMENTS : Participants had neurological and neuropsychological evaluations for dementia in 1991-93.
MEASUREMENTS : PARTICIPANTS rated patients ' quality of life using DEMQOL.
MEASUREMENTS : Participants were interviewed at baseline for sleep apnea.
MEASUREMENTS : Participants were randomized into a 9-month treatment of spironolactone @number@ mg / d vs placebo.
MEASUREMENTS : Participants were tested for both imagery and execution tasks of a Timed Up and Go ( TUG ) test.
MEASUREMENTS : Participants with weight measured at both surveys were followed for mortality through @number@
MEASUREMENTS : Patients were assessed using Comprehensive Geriatric Assessment ( CGA ) tools.
MEASUREMENTS : Patterns and amounts of informal and formal care by cognition and area of residence.
MEASUREMENTS : Percent annualized BMD change and fracture risk were compared across klotho quartiles.
MEASUREMENTS : Physical function was assessed using grip strength and gait speed.
MEASUREMENTS : Physical health and emotional well-being were evaluated.
MEASUREMENTS : Physicians clinically examined all participants using the same standardized protocols in both living areas ; trained nurses directly assessed disability.
MEASUREMENTS : Plasma amino acid measurements and biochemical analyses were performed.
MEASUREMENTS : Plasma CRP was measured using enzyme-linked immunosorbent assay.
MEASUREMENTS : Polypharmacy , defined as use of five or more medications and a cohort-specific alternate definition of eight or more medications , was examined.
MEASUREMENTS : Prefracture nutritional status was determined by Mini Nutritional Assessment ( MNA ) .
MEASUREMENTS : Preloss grief was measured at baseline , and postloss grief was measured @number@ and @number@ months postloss using the Prolonged Grief Disorder Scale.
MEASUREMENTS : Preoperative evaluation included assessment of frailty using the FP and FI.
MEASUREMENTS : Prevalence of xerostomia assessed from age , total number of medications , xerogenic medications , anticholinergic medications and those that induce hypersialorrhea.
MEASUREMENTS : PRIMARY OUTCOME : 1RM leg press.
MEASUREMENTS : Primary outcomes included metabolic conditions : obesity , diabetes , hypertension , and hyperlipidemia.
MEASUREMENTS : Primary outcome : Survival time ; in some analyses , adjustments were made for gender , age and self-perceived health.
MEASUREMENTS : Primary outcomes were delirium duration ( Confusion Assessment Method ) and delirium severity ( Delirium Rating Scale ) .
MEASUREMENTS : Primary outcome was gait speed assessed by the 400M walk.
MEASUREMENTS : Prohepcidin , ferritin , soluble transferrin receptor , erythropoietin and interleukin-6 were measured using commercially available ELISA kits.
MEASUREMENTS : Protein intake ( g / kg body weight / d ) was calculated using an interviewer-administered 108-item food frequency questionnaire at baseline.
MEASUREMENTS : Psychometric data on validity and reliability were extracted from the articles.
MEASUREMENTS : Pure-tone audiometry measurement and history of clinical CVD were obtained at the fourth annual follow-up visit.
MEASUREMENTS : Quality assessment was conducted using an adapted version of the Joanna Briggs Institute critical appraisal tool.
MEASUREMENTS : Quality of life was measured using the World Health Organization Quality of Life ( WHOQOL-BREF ) questionnaire.
MEASUREMENTS : Rates of comorbid conditions , healthcare utilization , costs , and mortality.
MEASUREMENTS : Rates of errors related to medication , dose and form , preparation , route , and timing.
MEASUREMENTS : Ratings of fatigue , fatigue-related cues , and sadness in facial photographs.
MEASUREMENTS : Readmission was assessed in multiple interviews with participants and family members over @number@ months and validated against medical record review.
MEASUREMENTS : Registrar of Vital Statistics-established 5-year mortality.
MEASUREMENTS : Research staff used standardized observations and weighed-intake methods to measure frequency of between-meal delivery , staff assistance time , and resident caloric intake.
MEASUREMENTS : RMR was measured using indirect calorimetry and body composition by bioelectrical impedance analysis.
MEASUREMENTS : Samples used for IB data were collected at baseline.
MEASUREMENTS : SA was operationalized in accordance with the phenotype proposed by Rowe and Kahn.
MEASUREMENTS : Scales on God Image and Religious Coping.
MEASUREMENTS : Self-neglect was assessed with systematic observations of a participant's personal and home environment.
MEASUREMENTS : Self-reported data on sociodemographic characteristics and medical conditions , Short Portable Mental Status Questionnaire , activities of daily living ( ADLs ) .
MEASUREMENTS : Self-reported history of falling two or more times in the prior year was the main predictor.
MEASUREMENTS : Self-reported use of regularly taken drugs.
MEASUREMENTS : Serum 25-hydroxyvitamin D levels were measured using liquid chromatography / tandem mass spectrometry analysis.
MEASUREMENTS : Serum GGT level , oxidized low-density lipoprotein ( oxLDL ) , CV comorbidities , all-cause and CV mortality.
MEASUREMENTS : Serum levels of @number@ hydroxyvitamin D ( 25 ( OH ) D ) , sun index , and skin phototypes were evaluated.
MEASUREMENTS : Severe sepsis was detected using a standard administrative definition.
MEASUREMENTS : Sexuality and intimacy were assessed using four questions.
MEASUREMENTS : Six ADLs organized into five stages ranging from no difficulty ( @number@ ) to unable ( IV ) .
MEASUREMENTS : Six repeated measurements of immediate and delayed recall of @number@ words over 10-year follow-up.
MEASUREMENTS : Skinfold thickness was used to estimate BD through Visser et al. prediction equation.
MEASUREMENTS : Sleep duration was self-reported at baseline.
MEASUREMENTS : Social services agency identified reported elder self-neglect.
MEASUREMENTS : Social ties were assessed using the 14-item form of the questionnaire for social support ( F-SozU K-14 ) .
MEASUREMENTS : Socio-demographic and clinical data , including nutritional status ( Mini-Nutritional Assessment - short form ) , was collected within @number@ hours of admission.
MEASUREMENTS : Socio-demographic correlates , dietary habits , health behaviours , grip strength , upper arm circumference , and waist circumference were collected.
MEASUREMENTS : Sociodemographics were collected by trained interviewers using a general questionnaire.
MEASUREMENTS : Spatio-temporal and three-dimensional gait characteristics were assessed by an electronic walkway and a shoe-mounted , inertial sensor-based mobile gait analysis system.
MEASUREMENTS : SRMH was measured with a single item , \ "How would you rate your own mental health ? \ "
MEASUREMENTS / STATISTICAL ANALYSIS : Subjects underwent a standardized clinical examination which included cognitive tests and self-reported cognitive difficulties scale ( 2007-2009 ) .
MEASUREMENTS : Statistical sampling techniques included cluster , stratification , and random selection.
MEASUREMENTS : Study of Osteoporotic Fractures participants had body weight measured repeatedly over @number@ years ( mean @number@ weights ) .
MEASUREMENTS : Subjective cognitive self-report measures included the Memory Functioning Questionnaire ( MFQ ) , Cognitive Failures Questionnaire , and the Subjective Cognitive Complaint Scale.
MEASUREMENTS : Subjects were administered the PHQ-9 and Structured Clinical Interview for DSM-IV-TR- fourth edition.
MEASUREMENTS : Survey questionnaires assessed : ED geriatric services ( @number@ items ) and nursing and geriatric staffing resources.
MEASUREMENTS : The 15-item Geriatric Depression Scale was used to measure depressive symptoms.
MEASUREMENTS : The 3MS , age , gender , education , living arrangements , self-rated health , and depressive symptoms were self-reported.
MEASUREMENTS : The appendicular skeletal muscle mass of the arms and the legs combined was assessed by dual energy x-ray absorptiometry ( DEXA ) .
MEASUREMENTS : The association between anticholinergic load calculated with nine different instruments and four anticholinergic adverse outcomes was investigated in univariate and multivariate analyses.
MEASUREMENTS : The authors measured cognitive decline using change in Mini-Mental State Examination ( MMSE ) scores over up to @number@ months.
MEASUREMENTS : The Blessed ( BIMC ) test was used to assess global cognitive status.
MEASUREMENTS : The care that residents received over successive 6-month periods was measured as a time-dependent covariate.
MEASUREMENTS : The clinical history and VFS exams of patients ≥ @number@ years were retrospectively analyzed.
MEASUREMENTS : The dependent variable was whether shopping was easy or difficult.
MEASUREMENTS : The EXIT and other measures of executive control functions ( ECF ) , non-executive cognitive domains , and global cognitive function.
MEASUREMENTS : The general anxiety subscale of the Hospital Anxiety and Depression Scale.
MEASUREMENTS : The Hospital Anxiety and Depression Scale ( HADS ) screened for anxiety and depression.
MEASUREMENTS : The importance , easiness , and achievement ( i.e. , implementation level ) of @number@ quality management practices were used.
MEASUREMENTS : The independent variables were any statin use and their standardized daily doses ( low , moderate , high ) and lipophilicity.
MEASUREMENTS : The laboratory data of female patients were collected and the telomere length parameters in their peripheral blood leukocytes were determined by Southern blotting.
MEASUREMENTS : The Life-Space Assessment ( LSA ) measures mobility by asking about movement in situations ranging from within one's dwelling to beyond one's town.
MEASUREMENTS : The likelihood of SNF admission after hospitalization was calculated.
MEASUREMENTS : The main outcomes were : number of days of constipation or diarrhea and the number of days of laxative use.
MEASUREMENTS : The Mini Nutritional Assessment ( MNA ) tool and a structured questionnaire were used in assessing the residents.
MEASUREMENTS : The Mini Nutritional Assessment-Short Form was used to assess nutritional status at baseline.
MEASUREMENTS : The modified Brief Confusion Assessment Method was used to ascertain delirium in the ED and hospital.
MEASUREMENTS : The Montreal cognitive assessment ( MoCA ) was used to screen the subjects with MCI.
MEASUREMENTS : The nutritional status of participants was assessed through the Mini Nutritional Assessment-Short Form ( MNA-SF ) .
MEASUREMENTS : The nutritional status of participants was assessed through the Mini Nutritional Assessment Short Form ( the revised MNA-SF ) .
MEASUREMENTS : The occurrence of hypertension was assessed by self-report.
MEASUREMENTS : The onset of dementia was defined according to International Classification of Diseases , Ninth Revision , code.
MEASUREMENTS : The outcome of the study was the occurrence of any adverse drug reactions during the hospital stay.
MEASUREMENTS : The participants ' handgrip strength , medical history , and blood samples were taken.
MEASUREMENTS : The patients were evaluated in relation to different frailty , comorbidity , and disability instruments during their hospital stays.
MEASUREMENTS : The prevalence of AF was assessed by ECG and chart review.
MEASUREMENTS : The prevalence of malnutrition in the combined database and in the four settings was examined.
MEASUREMENTS : The primary decision subjected to this analysis was referral for permanent residential care.
MEASUREMENTS : The primary endpoint was survival at @number@ year and at @number@ year follow-up.
MEASUREMENTS : The primary outcome was average daily step count for the @number@ days before the 12-month interview.
MEASUREMENTS : The primary outcome was BP control at 6-month intervals over @number@ months.
MEASUREMENTS : The primary outcome was change in weekly steps walked as measured using the pedometer.
MEASUREMENTS : The primary outcome was elder abuse defined according to International Classification of Diseases , Ninth Revision , Clinical Modification diagnosis codes.
MEASUREMENTS : the primary outcome was the rate of meeting the endotracheal intubation ( ETI ) criteria.
MEASUREMENTS : The primary predictor was B2M level.
MEASUREMENTS : The primary studies used interview and focus group methods.
MEASUREMENTS : The Richmond Agitation-Sedation Scale ( RASS ) is a 10-second arousal scale ; a score of @number@ indicates normal arousal.
MEASUREMENTS : The scale development sample and BLSA participants self-administered an initial 26-item perceived fatigability scale.
MEASUREMENTS : The standing height , fibula length , ulna length , hip circumference and body weight were measured and the reported height was recorded.
MEASUREMENTS : The study analyzed @number@ and @number@ datasets of the Taiwan Longitudinal Survey on Aging ( TLSA ) .
MEASUREMENTS : The Subjective Global Assessment was used to determine prevalence of malnutrition at baseline and six months post intervention.
MEASUREMENTS : The tastiness score and the willingness score were the primary outcome measures.
MEASUREMENTS : The three investigators extracted and appraised data using the same study design , baseline characteristics , and outcomes , independently.
MEASUREMENTS : Thoracic kyphosis ( Cobb angle , T4-T12 ) was measured in degrees using supine CT scout images.
MEASUREMENTS : Three models were developed.
MEASUREMENTS : TILDA is a nationally representative prospective cohort study of community dwelling adults aged @number@ years and over in the ROI.
MEASUREMENTS : Time to achieve FTSS , and SPMSQ score.
MEASUREMENTS : Total physical activity was estimated using metabolic equivalent hours / week for the questionnaire and mean acceleration for the accelerometer.
MEASUREMENTS : Total serum carotenoids , a marker of fruit and vegetable intake , and physical activity were measured at baseline.
MEASUREMENTS : Treatment response was assessed at least every @number@ months and more often if clinically needed.
MEASUREMENTS : Urinary incontinence was assessed using structured questionnaires.
MEASUREMENTS : Variables recorded included patient demographics , comorbidities , mental health , laboratory data , surgical information , and cerebrovascular disease.
MEASUREMENTS : Vascular , genetic and nutritional factors were assessed at baseline ( 1999-2001 ) and follow-up examinations of the 3C Study.
MEASUREMENTS : Visual impairment was defined as best-corrected visual acuity worse than 20 / 40 in the better-seeing eye or visual field less than 20°.
MEASUREMENTS : Vitamin D status was assessed with serum 25-hydroxyvitamin D ( 25 ( OH ) D ) concentrations from bloods drawn at visit @number@
MEASUREMENTS : We conducted a questionnaire survey at Japanese hospitals and used the data obtained from @number@ respondents for analysis.
MEASUREMENTS : Weight and height were collected for BMI analysis and frailty criteria were applied according to Fried et al.
MEASUREMENTS : Weight and lean and fat mass from dual-energy X-ray absorptiometry measured annually over @number@ years.
MEASUREMENTS : Weight and WC were reassessed three years after baseline.
MEASUREMENTS : Weighted percentages were used to describe sociodemographic and health-related characteristics of the study population.
MEASUREMENTS : Weight , height , triceps skinfold thickness and mid arm circumference were recorded at baseline.
Measurements were carried out at baseline and during follow-up.
Measurements were compared at baseline and at follow-up.
Measurements were compared using stepwise regression analysis.
Measurements were conducted at Pre , @number@ @number@ and 12weeks.
Measurements were conducted during the winter.
Measurements were done on three sites : cheek , protected , and exposed arm sites.
Measurements were made from a horizontal plane between the medial canthi to three points at the upper eyebrow margin.
Measurements were made in the crow's feet area and the differences were evaluated for statistical significance.
Measurements were made of short transient high frequency acoustic emission signals generated by knee joints under stress during repeated sit-stand-sit movements along with joint angle.
Measurements were made using inductively coupled plasma mass spectrometry ( Pb , Cd ) and a single purpose spectrometer AMA @number@ ( Hg ) .
Measurements were obtained under dilated and natural viewing conditions ( for accommodative efforts ranging from @number@ to @number@ diopters [ D ] ) .
Measurements were performed at baseline and @number@ months.
Measurements were performed at baseline , three and twelve months.
Measurements were performed before surgery and the fourth day after surgery.
Measurements were performed in different proximo-distal regions for GM , GL and SOL.
Measurements were performed in the subfoveal position and at @number@ μm nasally and temporally.
Measurements were performed twice in a row and repeated after @number@ week.
Measurements were performed with the MasterLab , or PneumoScreen systems ( CareFusion , Höchberg ) .
Measurements were self-reported questionnaires , biochemical measures , and clinical measures.
Measurements were taken after the 3-month intervention.
Measurements were taken by physiotherapists following an agreed protocol.
Measurements were taken directly from the computer console , using the measure mode function.
Measurements were taken in the primary position of gaze.
Measurements were taken only at the end of the intervention , and cytokine values were log-transformed.
Measurements were taken on the right arm , three times with @number@ minutes intervals.
Measurements were taken with software.
Measurements were transformed by SIAmetrics into arbitrary units and statistically analysed.
MEASUREMENTS : We used the Free and Cued Selective Reminding ( FCSR ) test to evaluate verbal episodic memory.
Measurements will be performed by research assistants not aware of group assignment.
Measurements will be taken at baseline , @number@ months , and @number@ months.
MEASUREMENTS : With the help of Inbody720TM , @number@ body composition variables were measured and @number@ variables were retained after data pre-processing.
MEASUREMENTS : WMH volume was measured through analysis of brain magnetic resonance imaging data.
MEASUREMENTS : Working hours and the Framingham risk score were measured at baseline.
MEASUREMENTS : Young-old and old-old patients were compared on process of care and outcome variables.
MEASUREMENT : The percentages of frail and non-frail subjects were calculated according to @number@ different definitions.
MEASUREMENT : Undernutrition was defined as a body mass index < 18.5.
Measurement with AS-OCT of the corneal and limbal ET could aid in clinical assessment and planning treatments of the cornea.
MEASURES AND ANALYSIS : Dietary intakes were collected using a 24-hour recall and @number@ food records.
MEASURES : Demographic characteristics , body composition , physical fitness , biomarkers , depression , and social support were measured.
Measures evaluated included egocentric pointing , allocentric pointing , and array reconstruction after physical or imagined spatial updating.
Measures except TST were dichotomized based on clinical thresholds.
MEASURES : five SHARE variables approximating Fried's frailty definition.
Measures from diffusion magnetic resonance imaging reflect changes in the substantia nigra of Parkinson's disease.
Measures included a validated computerized evaluation of domain-specific cognitive functioning and a 17-plex panel of plasma cytokines.
Measures included inflammatory cytokines and oxidative metabolites.
Measures included sociodemographic variables , self-reported medical conditions , activities of daily living ( ADLs ) , and instrumental activities of daily living.
Measures included the anterior tongue elevation pressure , posterior tongue elevation pressure , buccodental pressure , and lip pressure.
Measures included the Zarit Burden Interview , the FMTCG Scale , and the Medical Outcomes Short Form-36 , v2.
Measures included three FBCP constructs , namely demographic items and physical and mental health variables.
Measures include functional abilities , quality of life , recent falls , mobility dependence , community supports and health service usage.
Measures of attentional control in Stroop-type tasks discriminate healthy aging from early stage AD and predict future development of AD in cognitively normal individuals.
Measures of body mass index and waist circumference were obtained at baseline.
Measures of brain complexity were extracted using Fractal Dimension ( FD ) and calculated using the box-counting method.
Measures of cognitive and brain reserve consisted of psychosocial ( e.g. , education ) and anthropometric ( e.g. , craniometry ) variables , respectively.
Measures of cognitive stimulation both at work and outside work were available at baseline.
Measures of depression , global cognitive functioning , exercise , vascular health , cognitive reserve , sleep , and memory were collected.
Measures of driving precision and average speed were recorded.
Measures of entropy have been widely used to characterize complexity , particularly in physiological dynamical systems modeled in discrete time.
Measures of executive function and self-rated health were assessed at baseline , and self-rated health was assessed at follow-up.
Measures of executive function were examined as potential sources of variation in fact and source recall.
Measures of fasting plasma total and high-density lipoprotein ( HDL ) cholesterol were assayed , and LDL cholesterol was calculated.
Measures of final position accuracy , precision , and trajectory linearity showed robust asymmetries between the left and right arm groups of young adults.
Measures of functional performance including endurance , discomfort , motor control , and task performance were recorded for each of the task conditions.
Measures of global cognitive function were available for all three data sets.
Measures of group fit were included to examine whether social identification contributed to outcomes.
Measures of health care resource utilization included COPD-related and all-cause hospitalizations and emergency department ( ED ) visits.
Measures of higher quality in-hospital care were correlated with higher readmission rates.
Measures of inhibition , switching , and combined inhibition and switching were analyzed.
Measures of neighborhood disadvantage , such as the ADI , could potentially be used to inform policy and care after hospital discharge.
Measures of nonverbal reasoning , verbal declarative memory , verbal fluency , working memory , and processing speed were administered.
Measures of optimism , perceived stress , and anxiety were obtained over the course of the study.
Measures of pattern and variability did not change with retirement or age.
Measures of pharyngeal wall thickness and pharyngeal lumen area were compared between age groups with one-way ANOVAs using Sidak adjustments for post-hoc pairwise comparisons.
Measures of physical frailty , function , strength , balance , and gait speed were assessed at Weeks @number@ @number@ and @number@
Measures of physical function included usual-paced gait speed and performance on the Short Physical Performance Battery ( SPPB ) .
Measures of physical , psychosocial , cognitive , socio-demographic , and environmental factors were assessed via established motor performance tests , interviews , and proxy-reports.
Measures of posterior pharyngeal wall thickness were determined at rest and during maximum constriction of the pharynx during a 20-ml bolus swallow.
Measures of retinal microvasculature architecture measured in adulthood included diameters , tortuosity , lengths , and LDR.
Measures of self-esteem , depressive symptoms , and perceived stress were assessed at T1 and T2.
Measures of semantic clustering and recall were obtained across learning and delayed recall trials.
Measures of sleep continuity and sleep apnea were unrelated to cognition in these patients.
Measures of stability of the head , trunk , and whole body were quantified in ML , AP and combined APML directions.
Measures of the different concepts of successful ageing were constructed using baseline indicators.
Measures of three-dimensional biomechanical data during treadmill running at @number@.7m / s and measures of muscle strength and flexibility were compared between groups.
Measures of treatment complexity indicate an increasing investment for each course of linac treatment , but also the adoption of hypofractionated regimens.
Measures of U.S. neighborhood socioeconomic disadvantage are more readily available but are rarely used clinically.
Measures of verbal fluency are widely used in the assessment of cognitive functioning of the elderly.
Measures of white matter integrity in the brain are also heritable and highly sensitive to both normal and pathological aging processes across adulthood.
Measures of white matter lesions , white matter integrity , sulcal morphology and tractography were identified as novel biomarkers of early cognitive decline.
MEASURES : Semi-structured discussion guide.
MEASURES : Sociodemographic and frailty characteristics were assessed by structured instruments , along with mobility , assistive device use and falls.
Measures that incorporate specific biomarkers related to HIV infection , designed to predict mortality outcomes in individuals with HIV , are also discussed.
MEASURES : The PROOF participants underwent an extensive neuropsychological battery at baseline.
Measures used included the Psychological General Well-Being Schedule , the Geriatric Depression Scale-15 , and the Alcohol Use Disorders Identification Test ( AUDIT ) .
Measures vary widely across studies and a lack of standardized outcomes measures hinders cross-studies comparisons.
Measures were taken on femurs in situ , detached from the body , skinned and defleshed , or dried completely.
Measuring health related quality of life of old people has become an important public health issue with the aging of population in developing countries.
Measuring serum total testosterone ( TT ) levels is mandatory.
Measuring the level of the advanced glycation end products ( AGE ) is one of the possible principles underlying the functioning of the biological clock.
Measuring the psoas area may represent a strategy for predicting perioperative costs in spine surgery patients.
Meat consumption increased iron bioavailability and , thus , physical and mental fitness.
Meat Sci.
Meat shear force , and color and lipid stability were evaluated at @number@ @number@ @number@ and @number@ days of simulated retail display.
Mechanical and geometrical cues influence cell behaviour.
Mechanical characterization of the LC is challenging because of the complex 3D shape and inaccessibility of the tissue.
Mechanical loading is a key mechanism linking both tissues with a central promoting role of physical activity.
Mechanical loading of muscle action is concentrated at muscle attachment sites ; thus there may be a potential for site-specific variation in cortical bone thickness.
Mechanical loading was categorized as body weight and composition , compartmental load , structural lesion , and physical activity.
Mechanical properties in the longitudinal direction deteriorated more quickly than those in the transverse direction for the whole femoral head.
Mechanical stresses are crucial for the maintenance of the morphologic and functional integrity of articular cartilage.
Mechanical tensile strain in the peripapillary sclera is significantly higher than the strain in the sclera farther away from the ONH.
Mechanical wounding reduced fibroblast aromatase activity but increased keratinocyte activity , amplifying the bioavailability of intracellular estrogen.
Mechanic and pragmatic cognitive functions are known to serve as resources when using technology in everyday life.
Mechanism dissection found that the CCL2 / CCR2 signal plays the key role in the mediation of TR4-promoted PCa cells migration / invasion.
Mechanism of POCD is considered to be due to the inflammatory response and Ca2 + dysregulation of the brain.
Mechanisms connecting aging processes at the end of a long life to subjective well-being should be explored in future studies.
Mechanisms determining both functional rate of decline and the time of onset in aging remain elusive.
Mechanisms determining characteristic age-of-onset for neurological diseases are largely unknown.
Mechanisms include the requirement of a special form of tRNA sensitive to Se deficiency for translation of nonessential selenoprotein mRNAs except Dio1.
Mechanisms involved in neuroprogression in BD remain largely unknown although several non-mutually exclusive models have been proposed as explanatory frameworks.
Mechanisms leading to KS testis degeneration are still not completely defined but considered to be mainly the result of germ cells loss.
Mechanisms leading to the impairment of microcirculation in diabetes are multiple and still largely unclear.
Mechanisms of aging and menopause are discussed.
Mechanisms of declining Treg inducibility are not understood , but may provide an opportunity for targeted immunomodulation in the elderly.
Mechanisms of injury differ significantly by sport and can be potential targets for concussion risk mitigation.
Mechanisms of SPP1 overexpression in gliomas are poorly understood.
Mechanisms of these processes and their significance for cellular homeostasis are poorly known and present an important challenge for molecular biology.
Mechanisms probably contributing to fatigue in older adults include decline in mitochondrial function , alterations in brain neurotransmitters , oxidative stress , and inflammation.
Mechanisms related to cellular cholesterol , phenotypic plasticity , metabolism , and aging play key roles in affecting these responses.
Mechanisms relevant to immigrant elderly populations are virtually unexplored.
Mechanisms responsible for altered retinal flicker response in preeclampsia need to be clarified in further studies.
Mechanisms , such as inflammatory processes , have been suggested to relate this association.
Mechanisms that contribute to healthy aging remain obscure.
Mechanisms that enable tumor infiltration of CD8 Age-associated clonal hematopoiesis caused by acquired mutations in myeloid cancer-associated genes is highly prevalent in the normal population.
Mechanisms that govern genome integrity and stability are major guarantors of viability and longevity.
Mechanisms that promote the homeostasis of the proteome , or proteostasis , can slow aging and decrease the incidence of age-related diseases.
Mechanisms underlying intra-brain MP propagation / deposition remain essentially uncharacterized.
Mechanisms underlying phenotypic heterogeneity in young onset Alzheimer disease ( YOAD ) are poorly understood.
Mechanisms underlying the effects of low-dose ionizing radiation ( IR ) exposure ( 10-100 mGy ) remain unknown.
Mechanisms underlying the observed association need to be further characterized.
Mechanisms underlying the relationship require further investigation , as S-Cu may contribute to sleep regulation through pro-oxidative processes and copper-dependent N-methyl-d-aspartate receptor activity.
Mechanisms will be discussed in the context of therapy that interferes with Rheb's activity using the antibiotic rapamycin or low molecular weight compounds.
Mechanistically , activation of the Hippo pathway effector Yes-associated protein ( YAP ) underlies macrophage recruitment by TICs.
Mechanistically , Ang2 blockade could be linked to quenching the inflammatory and angiogenic response of endothelial cells ( ECs ) in the metastatic niche.
Mechanistically , astrocytic regulation of hypothalamic extracellular GABA level and therefore BDNF expression were found partly accountable.
Mechanistically , BHB inhibited the NLRP3 inflammasome in neutrophils by reducing priming and assembly steps.
Mechanistically , BHB inhibits the NLRP3 inflammasome by preventing K ( + ) efflux and reducing ASC oligomerization and speck formation.
Mechanistically , BMP2 overexpression increase phosphorylated protein level of mTOR , S6K and 4EBP1.
Mechanistically , both LOAD mutations impaired the molecular chaperone activity of ADAM10 prodomain.
Mechanistically , CD74-NRG1 leads to extracellular expression of the EGF-like domain of NRG1 III-β3 , thereby providing the ligand for ERBB2-ERBB3 receptor complexes.
Mechanistically , coexpression with a dominant-negative dynamin II prevented the regulation of TRPV5 by sKL but not by mKL.
Mechanistically , CSB can displace activated PARP1 from damaged DNA to limit its activity.
Mechanistically , frailty at its root is a symptom of growing old , with cascades and circuitous feedback between organ systems at all levels.
Mechanistically , HS-1793 inhibited HIF-1α and VEGF expression through multiple mechanisms.
Mechanistically , hyper-activated mTOR ( Target of Rapamycin ) may render young males robust at the cost of accelerated aging.
Mechanistically , injury may be due to hemodynamic effects , tubular or glomerular toxicity , and interstitial nephritis.
Mechanistically , NKX3.1 and DYRK1B were shown to interact via the DYRK1B kinase domain.
Mechanistically , NS induction correlates with Pim-1 kinase-mediated stabilization of c-Myc.
Mechanistically , OTUB2 suppresses RNF8-mediated L3MBTL1 ubiquitination and Lys 63-linked ubiquitin chain formation in a deubiquitinating activity-dependent manner.
Mechanistically , RES is involved in down regulating the inflammatory response.
Mechanistically , RHAMM expression is regulated by the testis-specific polyadenylation protein CFIm25 , which is downregulated in the human seminomas.
Mechanistically , SIRT1 increases α-secretase production and activity through activation of the α-secretase gene ADAM10.
Mechanistically , SIRT3 mediates metabolic reprogramming by destabilizing hypoxia-inducible factor-1α ( HIF1α ) , a transcription factor that controls glycolytic gene expression.
Mechanistically , SIRT6 regulates Tau protein stability and phosphorylation through increased activation of the kinase GSK3α / β.
Mechanistically , SIRT7 deacetylates and promotes SMAD4 degradation mediated by β-TrCP1 , and SIRT7 deficiency activates transforming growth factor-β signaling and enhances epithelial-to-mesenchymal transition.
Mechanistically , we find that both Ku and SIRT1 are induced during restoration and are required for senescent cells to return to a youthful phenotype.
Mechanistically , we find that phosphorylation of S321 inhibits RIPK1 kinase activation.
Mechanistically , we find that the E2 ubiquitin-conjugating enzyme and IPO11 cargo , UBE2E1 , is a limiting factor for PTEN degradation.
Mechanistically , we show that IL-2 drives preferential proliferation and accumulation of Bim ( lo ) Treg.
Mechanistic analysis revealed a rapid onset of mitochondrial-dependent apoptosis , including mitochondrial depolarization , cytochrome C release and the activation of specific caspases.
Mechanistic and evolutionary perspectives both agree that aging involves multiple integrated biochemical networks in the organism.
Mechanistic causal relationships between these parameters need to be investigated.
Mechanistic investigations suggested that this pathway supported the cytotoxic response to cisplatin and doxorubicin by licensing an apoptotic process controlled by mitochondria.
Mechanistic studies revealed that MCL suppressed LPS-stimulated the activation of IκBα / NF-κB pathway and Akt pathway.
Mechanistic studies should determine which tea bioactive constituents have effects , whether they act alone or in combination , and how they influence health.
Mechanistic studies should include exploration of influences of biologic aging processes on human resiliencies.
Mechanistic target of rapamycin controls cell growth , metabolism , and aging in response to nutrients , cellular energy stage , and growth factors.
Mechanobiology has shifted our understanding of fundamental cellular and physiological functions.
Med.
Med.
Med.
Med diet induced higher postprandial SOD2 and TrxR mRNA levels , and CHO-PUFA diet induced higher GPx1 and TrxR mRNA levels compared with SFA-rich diet.
Media are to report to the public topics of importance to them.
Medial and lateral temporal differences during encoding and maintenance are consistent with previous findings , but lateral temporal differences are often not elaborated upon.
Medial orbital fat prolapse and skin laxity had the highest proportion of grade @number@ scores of @percent@ and @percent@ , respectively.
Medial temporal structures showed different atrophy dynamics along the progression of the disease.
Median ADAS-Cog values ( @number@ versus @number@ points ) ( P = 0.045 ) were significantly better with PRM.
Median ADL index was @number@ ( IQR 0-9 ) , and @percent@ of patients were living at home.
Median age at enrollment was @number@ ( interquartile range 53-70 ) years.
Median age at first admission to HPC was younger in immigrants than non-immigrants : 61-70 vs. 71-80 , p = @number@
Median age at primary diagnosis was @number@ years ( range 16-93 ) and @number@ patients ( @percent@ ) had a high-grade serous ovarian cancer.
Median age at transfer was @number@ years.
Median age of @number@ patients who received chemotherapy was @number@ years ( range 21-86 years , @percent@ was ≥80 years ) .
Median age of patients undergoing CTC was @number@ ( range , 27-96 ) years.
Median age of patients was @number@ years ( range 25-42 years ) .
Median age of subjects was @number@ years ( interquartile range @number@ to @number@ ) .
Median ages at natural menopause and the survival curves were estimated by the Kaplan-Meier method.
Median age was @number@.9±7.5 years and @number@ were men.
Median age was @number@ ( IQR 25-52 ) ; 16 / 17 were men.
Median age was @number@ years.
Median age was @number@ years ( 31-83 ) , @number@ % were female.
Median age was @number@ years [ Interquartile Range ( IQR ) @number@ ] with a slight predominance ( @number@ % ) of females.
Median age was @number@ years ( IQR : 59-67 ) .
Median and ulnar nerves in one upper , peroneal posterior tibial and sural nerves were studied in both lower extremities.
Median baseline sCr was @number@.0mg / dl ( range : @number@.4-2.1 ) and median baseline eGFR was @number@ ( range : @time@ @number@ ) .
Median CAC was @number@ ( IQR @number@ @number@ ) .
Median cancer-specific survival was @number@ months ( @percent@ confidence interval 13-25 ) .
Median changes in most of these variables were also significantly different from those in the control group.
Median Charlson comorbidity index score was @number@ ( range : 0-8 ) .
Median cIMT was significantly larger for men than women ( @number@.56mm vs. @number@.53mm ; p = @number@ overall = @number@.54mm ) .
Median duration of follow-up was @number@ days.
Median duration of sarcoidosis was higher in the OS group ( @number@ versus @number@ years , p = 0.031 ) .
Median event-free and overall survival was @number@ and @number@ months , respectively.
Median FI was @number@ and @number@ patients ( @percent@ ) were considered frail with FI ≥0.15.
Median followup on active surveillance was @number@ years ( @number@.3-5.0 ) and the median number of biopsies was @number@ ( 3-6 ) .
Median follow-up since craniopharyngioma presentation was @number@ years ( interquartile range : 5-23 years ) .
Median follow up time was 115months ( range , 60-211months ) for a minimum of five years.
Median follow-up time was @number@ months ( range : 6-140 months ) .
Median follow-up time was @number@ ( to a maximum of @number@ ) years.
Median follow-up time was @number@ years.
Median follow-up time was @number@ years.
Median follow-up was @number@ ( interquartile range , @number@.4 8.1 ) years.
Median follow-up was @number@ ( range 18-84 ) months.
Median follow-up was @number@ years.
Median follow-up , which involved standardized monthly assessment of falls , was @number@ months in all study groups.
Median frailty prevalence was @percent@.
Median HDI scores ranged from @number@ to @number@ points across cohorts.
Median initial tumor size was @number@.1cm ( range : @number@.8-4.0 ) .
Median intensity of LAN exposure was @number@ lux ( interquartile range , @number@ @date@ ) .
Median intra- and interlaboratory reproducibility was < 20% , sufficient for most biological studies and candidate protein biomarker verification.
Median length of hospital stay were @number@ and @number@ days , respectively ( P = @number@ ) .
Median length of stay was @number@ days for STRIDE participants and @number@ days for individuals receiving usual care ( P = @number@ ) .
Median LLAC was @number@ ( @date@ @number@ ) mgHA and median CAC as expressed by Agatston score was @number@ ( @number@.88-1877.28 ) .
Median marginal tumor dose was @number@ Gy.
Median MEWS was ( range 0-11 ) .
Median MMSE and median I-ADL showed good performance range until age @number@ median P-ADL was close to zero up to age @number@
Median observation time was @number@ months ( IQR @date@ @number@ ) .
Median observed survival increased from @number@ years in 1952-1963 to @number@ years in 2003-2012.
Median observed survival was significantly shorter in men than in women in 1993-2002 ( @number@ vs. @number@ years , P < @number@ ) .
Median onset was @number@ days , which conforms to CONCLUSION : Medical delirium articles have failed to establish rapid onset and rapid recovery.
Median participant age was @number@ years ; @percent@ were men ; @percent@ were black , and @percent@ were HIV infected.
Median percentage excess weight loss was @number@ per cent at @number@ months and @number@ per cent at @number@ months.
Median preoperative weight was @number@ kg and median BMI @number@ kg / m ( @number@ ) .
Median protein IL-6 was @number@ pg / mL ( interquartile range : @number@ ) .
Median % reductions in AK lesions were @percent@ , @percent@ , and @percent@ respectively ( P < .001 versus vehicle ) .
Median sacral curvature angles and lumbosacral lordotic angles were measured as 164° and 134° , respectively.
Median specificity was @percent@ , with @number@ of @number@ of the readers having specificity greater than @percent@.
Median survival in hospice was only @number@ days and did not differ significantly by functional trajectory.
Median survivorship of deceased patients was @number@ days.
Median time from AD dementia diagnosis to death was @number@ years.
Median time from administration until the return to normal temperatures was @number@ h ( @percent@ CI : @date@ @number@ ) .
Median time from AML diagnosis to first PC consultation was @number@ month.
Median times of latest serum creatinine dosage were @number@ days ( prior ) and @number@ days ( after ) .
Median time to CVD event was @number@ versus @number@ years ( P = 0.11 ) .
Median time to fall was @number@ days ( @percent@ CI , @number@ to @number@ ) .
Median time to first recurrence was @number@ months ( range @number@ days-4.8 months ) .
Median tract g-ratio values were also extracted.
Mediating factors in this decision process may be caused by self-perceived poor work ability and / or health.
Mediational analyses indicated that obsessive-compulsive symptom severity mediated the relationship between anxiety sensitivity and obsessive-compulsive related impairment.
Mediation analyses , as well as , multivariate logistic regressions were conducted.
Mediation analyses controlling for contextual variables tested the explanatory role of optimism.
Mediation analyses revealed both direct and grey matter-mediated effects of 18F-AV-1451 uptake on cognitive performance.
Mediation analyses revealed that psychologically resilient individuals rebound from daily pain catastrophizing through experiences of positive emotion.
Mediation analyses showed that the association between mindfulness and cognitive function is mediated by perceived stress.
Mediation analyses were completed to examine our hypothesis that EF would mediate the CR and FA relationship.
Mediation analyses were performed in a subset of @number@ participants for whom information was available on both PFASs and THs.
Mediation analysis also demonstrated that WMH in temporal , limbic , and subcortical regions might mediate the relationship between BDNF's genetic effect and STM performance.
Mediation analysis estimated that ICAM-1 methylation mediated @percent@ of the association of 28-day PM2.5 with FBG.
Mediation analysis helps researchers assess whether part or all of an exposure's effect on an outcome is due to an intermediate variable.
Mediation analysis indicated that part of this association was mediated by ICAM-1 promoter methylation.
Mediation analysis is a valuable approach to examine pathways in epidemiological research.
Mediation analysis revealed that lifetime smoking accounted for a sizeable proportion ( @percent@ ) of the educational differential.
Mediation analysis revealed that neither antiretroviral medication adherence nor body mass index contributes to the association between food insecurity and unsuppressed HIV-1 RNA.
Mediation analysis was also performed.
Mediation analysis was used to disentangle total and direct effects and the indirect effect mediated by BMI.
Mediation effects were studied with hierarchical regression and bootstrapping analysis.
Mediation formulae for longitudinal data have been developed.
Mediation models were employed to test the mediating effect of brain lesions on the association of diabetes with cognitive performance controlling for potential confounders.
Mediation models were used to examine study hypotheses.
Mediator analysis was performed using Sobel test.
Mediators included depression severity ( Patient Health Questionnaire ) , depression knowledge and symptom recognition , behavioral activation , and anxiety.
Medical advancements have increased life expectancy but have consequently increased the incidence of age-related disease.
Medical and lifestyle information was obtained using standardized questionnaires.
Medical and neuropsychological data from @number@ healthy volunteer controls , aged 26-91 years , were collected during five recruitment occasions.
Medical and radiological records were reviewed to determine any urinary symptoms and final outcome.
Medical and surgical risks for head and neck cancer patients over a certain age who undergo free tissue transfer has hardly been investigated.
Medical care at the end of life can be expensive , and is an urgent socioeconomic issue for aging societies.
Medical care contributes to the ongoing increase in life expectancy , which is currently @number@ years and second only to Japan.
Medical care is mainly based on alleviating pain symptoms.
Medical comanagement ( @percent@ ) , inpatient PT / OT ( @percent@ ) , and postacute PT / OT ( @percent@ ) occurred more frequently.
Medical co-morbidities , including stasis dermatitis and venous ulcerations , further exacerbate this clinical picture.
Medical complications were observed in @number@ cases and were predominantly pulmonary , whereas surgical complications occurred in @number@ cases in addition to one perioperative death.
Medical conditions and a comprehensive geriatric assessment were recorded for each patient.
Medical conditions were established from a combination of self-report , review of general practitioner and hospital discharge records , and analyses of fasting blood samples.
Medical data of the acute HUS episode were retrieved retrospectively from hospital records.
Medical diagnosis and age alone are usually insufficient criteria for determining fitness to drive.
Medical doctors , especially those not specialized in geriatrics , estimated worst.
Medical education must incorporate strategies to promote clinician attitudes that facilitate successful patient aging.
Medical files were reviewed to specify the final diagnosis.
Medical Forensic System should be installed in any kind of endoscopic procedures.
Medical history and medication use were determined , and the AD8 dementia screening instrument was used.
Medical innovations have created a future of survivorship for many groups of people with a variety of conditions that were previously untreatable or untreated.
Medical interventions should be compatible with goals of care and balance benefits and burdens for each intervention taking into consideration severity of dementia.
Medical issues have become a larger concern than any other issue for households.
Medically trained healthcare providers and community health practitioners can provide older adults with this information through health education classes.
Medical management of parkinsonian symptoms should be preferred with levodopa monotherapy.
Medical needs because of tachycardia often appear late in adulthood.
Medical practice is often based on single disease guidelines derived from clinical trials that have not included frail older people or those with multiple morbidities.
Medical practitioners are required to record the procedures precisely in order to check the procedures retrospectively and to get the legally reliable record.
Medical practitioners require an understanding of these changes in order to find ways to optimise sexual function in older patients.
Medical professionals and caregivers must carefully assess psychiatric symptoms in the elderly patients while respecting their self-esteem.
Medical record review showed that the project enhanced usual medical care with respect to home safety counseling.
Medical records from age @number@ years until the index visit were reviewed to determine exposures to general anesthesia.
Medical records of all identified patients would be reviewed retrospectively by two PC physicians.
Medical records of each patient were collected , including demographic information , cardiovascular risk factors , concomitant drugs and routine biological parameters.
Medical records of @number@ CU patients from the outpatient Allergy Clinic of Ajou University Hospital , Korea were analyzed retrospectively.
Medical records were accessed on average @number@ months post baseline , when new diseases and deaths were recorded.
Medical records were reviewed for dates of cataract surgery and glaucoma treatment.
Medical records were reviewed for demographics , dosing , reason for switching between products , treatment satisfaction , and interval between injection cycles.
Medical records were reviewed for patient characteristics and outcomes.
Medical records were reviewed for the year prior to the autonomic assessment.
Medical schools might explore the integration of this multi-language-capable SQA assessment and teaching instrument into their undergraduate medical curriculum.
Medical schools must consider innovative ways to ensure that graduates are prepared to care for the aging population.
Medical students have a number of unmet learning needs with regard to communicating with patients with dementia and their families.
Medical students underestimate the health and functional status of community-dwelling older adults and have little experience in health promotion interviewing or prescribing physical activity.
Medical therapy includes α ( @number@ ) blockers , 5 ( ) α reductase inhibitors and combination therapy.
Medical therapy of LOH should be individualized depending on the etiology of the disease and the patient's expectations.
Medical treatment that effectively prevents I / R injury would alleviate the consequent development of cardiac remodeling and failure.
Medicare costs were estimated from the National Long Term Care Survey.
Medicare covered skilled nursing days were estimated with a zero-inflated negative binomial model.
Medicare hospice payment methodology was revised starting in @number@
Medicare Part D has been successful in providing affordable prescription drug coverage with relatively high levels of beneficiary reported satisfaction.
Medicare Part D plans must provide medication therapy ( MTM ) services.
Medication adherence was examined during the post-index period using proportion of days covered ( PDC ) ≥80% and ≥90%.
Medication consisted of identical tablets containing either @number@ mg amitriptyline or placebo.
Medication did not alter the ApEn values.
Medication non-adherence is a pressing concern among seniors , leading to a lower quality of life and higher healthcare costs.
Medication review decreases the number of DRPs among these patients.
Medications and surgery have a very limited role in the treatment of oropharyngeal dysphagia.
Medication side effects are the most common contributing factors.
Medications may exacerbate this predisposition.
Medications taken at the time of ST titration were documented.
Medications taken in the previous @number@ weeks were recorded from medication bottles in the home interview.
Medications that induce hypersialorrhea protect against the occurrence of dry mouth.
Medication use also had no effect on all cognitive measures.
Medication use and relevant covariates were obtained by face-to-face interviews.
Medication was changed by the clinician after an adverse fall event in @percent@ of the falls.
Medicinal agents were consumed in the last two weeks by @percent@ of respondents.
Medicine and society better get ready for this revolution.
Medicine , including dermatology , and government act by restoring homeostasis when self-regulation is unable to do so.
Medicine individualized to patients ' cognitive ability and ability to act could improve adherence to prevention protocols among patients with chronic conditions.
Medicine needs to continue to enhance the existential maturity of our profession , our patients and the cultures in which we practice.
Medicines are associated with enormous health benefits but also with the potential to cause illness and death.
Mediolateral marker sway and intersegmental angular sway showed a clearer age dependency.
Mediterranean diet is a term used to describe the traditional eating habits of people in Crete , South Italy and other Mediterranean countries.
Mediterranean-type diet ( MeDi ) was calculated from dietary information collected using a food frequency questionnaire.
Medline and Embase were searched for observational studies and systematic reviews from @number@ to @number@
MEDLINE and EMBASE were systematically searched for articles published between @date@ and @date@ on delirium after vascular surgery.
MEDLINE , Embase , CINAHL® , CENTRAL and AMED databases were searched from their inception until @date@ .
MEDLINE , EMBASE , CINAHL , PsychINFO and AMED were searched.
MEDLINE-indexed articles published between @date@ and @date@ and bibliographies of these articles and related reviews were searched.
MEDLINE , PsycINFO , CINAHL , AgeLine , Scopus and PubMed were searched from @number@ to @date@ .
Medline searches were conducted for relevant articles , chapters and books published until @date@ .
MEDLINE was searched for reports published between @date@ and @date@ and additional studies were identified through searches of bibliographies.
Med. , @number@ ) .
Med Pr @number@ ; 67 ( @number@ ) : 691-700.
Med Pr @number@ ; 68 ( @number@ ) : 441-448.
Meeting participants discussed promising strategies for cancer prevention targeting this age group.
Meetings were held with staff members , who were asked to describe their experiences and suggest necessary improvements.
Meeting their needs regarding non-medical attributes of primary health care is important to improve the quality of care.
Meeting the medical , nutritional , and psychosocial mealtime needs of aged care residents requires a holistic , multidisciplinary approach.
Meeting the PA-recommendation was defined as amounting ≥150 min / week in MPA / MVPA or @number@ min / week in VPA , respectively.
Meeting the protein requirement was associated with changes in weight ( P < @number@ ) and serum albumin level ( P = @number@ ) .
Meibomian gland loss in ocular GvHD was described as a mechanism contributing to dry eye and severe damage to the ocular surface.
Meinzer et al.
Meiotic nondisjunction error was detected by STR genotyping.
Melanin is transferred to the hair shaft forming keratinocytes giving the hair its colour.
Melanocortins induce neuroprotection in experimental acute neurodegenerative conditions , and low melanocortin levels have been found in occasional studies performed in AD-type dementia patients.
Melanocytic matricoma is a rare cutaneous neoplasm of presumed anagen hair follicle origin with approximately @number@ reported cases in the literature.
Melanogenesis is an oxidizing process ; therefore , many antioxidants are used to inhibit melanin production.
Melanoma is the most lethal form of skin cancer and successful treatment of metastatic melanoma remains challenging.
Melatonin also acts through non-receptor-mediated mechanisms , for example serving as a scavenger for reactive oxygen species and reactive nitrogen species.
Melatonin and serotonin rhythms , which exhibit a close association with the endogenous circadian component of sleep , are attenuated with increasing age.
Melatonin , being a highly pleiotropic regulator molecule , interacts directly or indirectly with all the processes mentioned.
Melatonin decreases such as found with aging are or post pinealectomy can cause alterations in the sleep / wake cycle.
Melatonin dysfunction is frequently related to deviations in amplitudes , phasing , and coupling of circadian rhythms.
Melatonin has a remarkable array of means by which it thwarts oxidative damage.
Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep.
Melatonin is a highly pleiotropic signaling molecule , which is released as a hormone of the pineal gland predominantly during night.
Melatonin is an indoleamine produced mainly in the pineal gland.
Melatonin is an indoleamine that modulates a wide variety of endocrine , neural and immune functions.
Melatonin ( ) is secreted during the dark hours at night by the pineal gland.
Melatonin levels were significantly lower in patients reporting insomnia ( p = 0.05 ) .
Melatonin may reduce systemic inflammation through its direct and indirect antioxidative effect ; however , the associations of melatonin secretion with systemic inflammation remain unclear.
Melatonin protects the electron transport chain ( ETC ) in multiple ways.
Melatonin secretion decreases during aging.
Melatonin , the major product of the pineal gland , is considered an effective protector of mitochondrial bioenergetic function.
Melatonin , the major secretory product of the pineal gland , has free radical scavenging and antioxidative properties and protects against oxidative insult.
Melatonin , the major secretory product of the pineal gland , is a well-known antioxidant agent and thus an effective protector of mitochondrial bioenergetic function.
Melatonin , the neurohormone of the pineal gland , is also produced by various other tissues and cells.
Memantine is a symptomatic treatment that partially prevents cognitive decline in Alzheimer disease ( AD ) .
Memantine-treated patients had less decline from baseline on the ADL14 total score , compared with placebo ( p < @number@ ) at study end.
Member checking of site summaries was completed with site champions.
Memberships in the clusters of diverse and married / coresidence were significantly associated with more favorable ratings of health and lower levels of depressive symptoms.
Members of each generation carry with them a unique perspective of the world and interact differently with those around them.
Members of subject groups have significantly lower BMI categories ( p = @number@ ) compared with the control group.
Members of the sirtuin deacetylase / ADP-ribosyltransferase / deacylase family extend longevity in invertebrates and promote various aspects of mammalian healthspan.
Membrane contraction is an important sight-threatening event and is due to fibrotic remodeling.
Membrane fluidity was determined using an electron paramagnetic resonance spin-labelling method.
Membrane fluidity was evaluated by fluorescence anisotropy using the fluorescent probe diphenylhexatriene , and membrane fatty acid composition was assessed by gas chromatography.
Membrane interaction and subsequent Ca ( 2 + ) influx were the mechanisms that triggered inflammation.
Membrane IR levels , IRS-1 levels , and IRS-1 tyrosine phosphorylation were analyzed in CSF white cell pellets ( WCP ) using flow cytometry.
Membrane lipid composition is altered in the brain during the pathogenesis of several age-related neurodegenerative diseases , including Alzheimer's disease.
Membrane lipid composition is an important correlate of the rate of aging of animals and , therefore , the determination of their longevity.
Membrane lipids are not randomly distributed but are localized in different domains.
Membrane type and body location did not affect infection outcome significantly.
Membranous conjunctivitis and subepithelial opacities had the highest frequency of adenovirus types @number@ and @number@ respectively.
Memories retained after @number@ minutes but later forgotten were classified as transient , whereas memories retained after @number@ weeks were classified as durable.
Memory and dementia are historical ideas that preceded the development of modern neuroscientific , psychogeriatric and medical approaches to aging and cognitive impairment.
Memory and learning declines are consequences of normal aging.
Memory and set-shifting predicted performance in navigation-related secondary tasks , speed of processing predicted on-task safety errors , and visuospatial construction predicted baseline safety errors.
Memory challenges identified by these residents were used to develop a memory intervention for older adults residents of this and other AL facilities.
Memory changes in preclinical Alzheimer's disease ( AD ) are often characterized by heterogenous trajectories.
Memory complaining , assessed by current approaches , did not have an impact on personal memory.
Memory complaints are common in aging.
Memory comprised a recall composite.
Memory decline due to ageing may be noticed sooner in 55-64-year-olds performing cognitively demanding work.
Memory declined with age and ASC treatment improved performance in 9-month-old APP / PSEN1 and WT mice.
Memory deficits are reliably reported with age , but the tasks used to make these conclusions predominantly rely on conjunctive representations.
Memory deficits associated with aging and Alzheimer's disease have been linked to cholinergic dysfunction.
Memory deterioration is the earliest and most devastating cognitive deficit in normal aging and Alzheimer's disease ( AD ) .
Memory discrepancy scores ( M = 0.32 , SD = 1.22 ) were greater than zero.
Memory for details about activity , location , and who was present was good ; memory for all other details was poorer or at floor.
Memory for everyday events plays a central role in tasks of daily living , autobiographical memory , and planning.
Memory for target and contextual information was unrelated to factors of nonepisodic cognition , irrespective of encoding intentionality.
Memory for target ( WWW ) and contextual information was superior in the intentional group compared with the incidental group.
Memory for the action was enhanced by emotion , but emotion did not enhance the ability of participants to remember which person performed which action.
Memory-impaired clusters-mild-memory ( MILD-MEM ) and moderate-memory ( MOD-MEM ) -included @percent@ of patients.
Memory impairment is the cardinal early feature of Alzheimer's disease , a highly prevalent disorder whose causes remain only partially understood.
Memory improvements have been observed in Alzheimer's disease patients after long-term stimulation.
Memory-indifferent clusters mild-diffuse ( MILD-DIFF ) , moderate-language ( MOD-LAN ) and severe-diffuse ( SEV-DIFF ) -included @percent@ of patients.
Memory is an important capacity needed for survival in a changing environment , and its principles are shared across species.
Memory is central to our ability to perform daily life activities and correctly function in society.
Memory , language , attention / executive function , and visual-spatial processing domains were assessed within @number@ months of the MRI examination.
Memory loss in Alzheimer's disease ( AD ) is attributed to pervasive weakening and loss of synapses.
Memory loss often signifies loss of independence , which is a growing concern for residents in assisted living ( AL ) facilities.
Memory performance can be enhanced by expectations regarding the appearance of ensuing stimuli.
Memory performance was assessed by the Rey Auditory Verbal Learning Test ( RAVLT ) .
Memory performance was assessed with a free-recall task.
Memory , reasoning , vocabulary , and phonemic and semantic fluency were assessed 3× over @number@ years.
Memory sensitivity was greatest in young adults , although all groups showed increases in memory sensitivity and R judgments with repetition.
Memory-spared clusters ( MILD-VILA ) , mild-executive ( MILD-EXE ) and moderate-visuospatial ( MOD-VISP ) -included @percent@ of patients.
Memory T cells are heterogeneous populations.
Memory training effects were evident immediately following training and not after @number@ year following training.
Memory training effects were no longer maintained for memory performance.
Memory training had significant immediate effects on all measures of strategy use that were maintained through five years of follow-up.
Memory training has often been supported as a potential means to improve performance for older adults.
Memory was assessed for the study item and , for items judged old , the item's encoding task.
Memory was significantly associated with WMH volume in the forceps minor , independent of total WMH volume.
Memory was worse in men than in women overall ( P < @number@ ) and more specifically beyond age @number@ years.
Menadione is a metabolite of vitamin K that is excreted in urine.
Men aged 40-79 years were recruited from population registers for participation in the European Male Ageing Study ( EMAS ) .
Men , aged @number@ to @number@ low educational level , separated / divorced , and tobacco smoking were independently associated with lifetime alcohol misuse.
Men ages @number@ to @number@ years were recruited from population registers in @number@ European centres.
Men and older participants had more accelerometer-measured sedentary time than their counterparts.
Men and postmenopausal women were also scanned after pretreatment with a clinical dose of the aromatase inhibitor letrozole.
Men and women exhibit differences in the development and progression of Alzheimer's disease ( AD ) .
Men and women had different age related patterns , with significant sex by age interactions ( p < 0.001 ) .
Men and women reported similar , high levels of career satisfaction , with women reporting higher satisfaction currently.
Men and women show different wrinkling patterns yet the lifestyle and physiological factors underlying these sex-specific patterns are relatively unknown.
Men and women who engaged in frequent arousal-associated sleep behaviors demonstrated higher and lower heat temporal summation , respectively.
Men and women with a familial propensity to become long-lived have lower coronary artery calcium scores than controls.
Menarcheal age was in donors with normal FOR neither associated with race nor with FMR1 status.
Men are a fast growing segment of the aesthetic industry.
Men are more sensitive than women to overall family relations , while the relative importance of social relations is higher for women.
Men are @number@ cases ( @percent@ ) .
Menatetrenone also decreased the serum level of undercarboxylated osteocalcin.
Men benefited more from everyday shopping than women with decreased HR @percent@ versus @percent@ compared to the least.
Men completed a questionnaire on demographic , medication , and fracture-related information , and descriptive statistics were calculated using Statistical Package for the Social Sciences.
Men correctly identified health risks of being obese.
Men defined it as a disease of the bone that may increase the likelihood of fracture and that may cause pain.
Mendelian randomization analyses were performed using single nucleotide polymorphisms identified from previous genome-wide association studies.
Men displayed a higher proportion of smoldering plaques.
Men do , however , manifest distinct changes in somatic and gonadal function with age.
Men found a sense of pride , despite physical changes , in appreciating independence and close relationships.
Men from developed countries had the highest age-standardized death rates among all three cancers.
Men had a significant decrease in utilitarian walking , which women did not ( p = 0.07 ) .
Men had greater LV volumes and mass , before and after indexation to common measures of body size ( all P = @number@ ) .
Men had higher 6-month mortality rates ( HR = @number@ P < @number@ ) .
Men had higher levels than women ( @number@ ± @number@ vs. @number@ ± @number@ ng / ml ; p = 0.04 ) .
Men had higher mean endurance than women ( t = 3.309 ; p = 0.001 ) .
Men had lower 3DLε , 3DRε , 3DAε , and 2D longitudinal strain than women ( P < @number@ ) .
Men had lower body fat and higher aLM than women.
Men had more rectal cancers ( 2 : 1 ) and overall CRC ( @number@.7 : 1 ) .
Men had poorer scores in the chronic disease domain than women.
Men had significantly more level @number@ @number@ @number@ and @number@ eyebrow whitening compared with women.
Men have a higher incidence of cardiovascular disease ( CVD ) than women , and adverse thrombotic events increase with age.
Men have higher prevalences of colorectal neoplasms than women.
Men included in this study presented at the hospital and their symptomatic status was not known.
Men in their third decade of life exhibited significant diurnal variation ( P = @number@ ) , whereas older and younger age classes did not.
Men in transitional countries reported a higher prevalence of morbidities and impairment of sexual function as well as a lower QoL.
Meniscal damage is a frequent finding on MRI of the osteoarthritis ( OA ) knee.
Meniscal damage or resection causes changes in knee mechanics during walking , resulting in altered cartilage loading.
Men , less educated individuals , and those who reported not getting regular physical activity were at significantly higher risk for metabolic syndrome.
Men mostly work as surgeons , women were mostly employed as primary care specialists.
Men ( n @number@ ) and women ( n @number@ ) had follow-up BMD measured in 2002-2005.
Men often attributed their depression to stressors such as grief / loss and spousal conflicts , feelings of moral failure , and poor health.
Menopausal data suggest that the majority of women who had PCOS during their reproductive years continue to manifest cardiovascular risk factors.
Menopausal status was determined using the Stages of Reproductive Aging Workshop classification and women were classified in : premenopausal , perimenopausal or postmenopausal.
Menopause affects various women's health aspects , including bone density , breast , the cardiovascular system , mood / cognitive function and sexual well-being.
Menopause also partially reverses women's protective AT distribution.
Menopause and over-deep osteoclastic resorption are associated with incomplete BMU refilling leading to excessive porosity , cortical thinning and disconnection of trabeculae.
Menopause , denoted by a rapid decline in serum sex steroid levels , accelerates biological ageing across the body's tissues.
Menopause is a key point moment in the specific aging process of women.
Menopause is an inevitable component of ageing and encompasses the loss of ovarian reproductive function , either occurring spontaneously or secondary to other conditions.
Menopause is a normal part of a woman's lifecycle and consists of a series of body changes that can last from one to ten years.
Menopause is a relevant phase in a woman's reproductive life.
Menopause is a sign of aging in the woman.
Menopause is associated with a precipitous decline in circulating estrogens and a resulting loss of the neuroprotective actions of this steroid hormone.
Menopause is characterized by rapid decline in ovarian sex steroids already during mid-life , between the ages of @number@ and @number@
Menopause is the transition from reproductive to non-reproductive life well before natural death.
Menopause , while the end of reproduction , also represents a major hormonal , psychological and physiological event in the lives of all women.
Men outperformed women in the @number@ and @number@ cohorts but no difference was found in the @number@ cohort.
Men performed better than women in most cognitive abilities at baseline but had faster rates of decline in working memory.
Men reported falls history in previous @number@ months , FOF , health status and demographic characteristics.
Men reported higher frequencies of any physical activity and moderate-to-vigorous physical activity , and a lower frequency of physical activity inside the home.
Men require a unique injection technique with botulinum toxin and dermal fillers due to differences in facial anatomy.
Men's aesthetic dermatology is burgeoning with more men seeking cosmetic consultations and intervention.
Men's average age was @number@ years and their partners ' average age was @number@ years.
Men's couple sexual satisfaction was lowest ( Sexual Experience Questionnaire : M = @number@ SD = @number@ ) .
Men should then be reviewed at least annually thereafter.
Men show an age-related decline in the circulating levels of testosterone ( T ) and dehydroepiandrosterone sulfate ( DHEAS ) .
Men showed a better functional status over time ( p = @number@ ) than women.
Men showed greater leftward preference whereas women exhibited stronger rightward bias.
Men showed less disability and cognitive impairment ( p < 0.001 , for both ) .
Men show more significant decrease than women ( @percent@ vs. @percent@ ) .
Menstrual bleeding problems at baseline were the strongest predictor of hysterectomy ( HR , @number@ @percent@ CI , @number@ @date@ ) .
Menstrual bleeding problems were the major determinant of elective hysterectomy.
Menstrual cycle or postpartum mood exacerbation , or current hormone therapy use , was not associated with perimenopausal depression.
Menstruation and pregnancy are associated with a physiological inflammation , which is altered in preeclampsia and probably in other hypertensive situations of pregnancy.
Mental component summary score was not associated with body fat changes , but higher mental component summary score was associated with increasing age and time.
Mental component summary was inversely related to the 3-BSRS-subitem sum score and the GDS-15.
Mental disorders in the elderly often influence their social and physical wellbeing.
Mental disorders were not associated.
Mental health and solitude in old age.
Mental health and substance abuse treatment utilization was low among all elders with problems.
Mental health care in Australia in the last @number@ years has moved from stand-alone psychiatric hospitals to general hospitals and the community.
Mental health concerns pervaded the lives of these older adults.
Mental health disorders in terms of an aging population are discussed in this review.
Mental health improved significantly in the intervention group ( P = 0.037 ) .
Mental health is increasingly defined not only by the absence of illness but by the presence of subjective well-being ( SWB ) .
Mental health management for older adults requires comprehensive assessment of their social relations that takes into account their companionship during mealtimes.
Mental health policy encourages partnerships between carers and service providers to facilitate service access , coordination and positive experience of care.
Mental health problems , including cognitive capacity limitations , occur frequently.
Mental health scores were lower for women than men.
Mental health support was the most common care reported ( @percent@ ) .
Mental health was associated with better health behaviors , which in turn predicted positive physical health outcomes.
Mental health was determined by the General Health Quality ( GHQ-28 ) questionnaire.
Mental stress at Tsk @number@.5°C further increased SSNA in both groups.
Mental time travel was even higher correlated with retrospective time estimation.
Mental Training of familiar movements could therefore be feasible for older adults and enables promising intervention strategies.
Mentorship and collaboration ties were present both within and across boundaries of HAN member organizations.
Mentors who reported more institutional incentives also reported spending a greater percentage of time mentoring ( P = @number@ ) .
Men undergo gradual bone loss with aging , resulting in fragile bones.
Men undergoing radical prostatectomy and men with well-differentiated tumors were more likely to receive testosterone ( all P < @number@ ) .
Men walked more than women.
Men were analyzed to control for aging.
Men were at lower risk of CKD-S3-5 than women ( OR = @number@ @percent@ CI @number@ @date@ ) .
Men were diagnosed at a significantly younger age than women.
Men were heavier and had more lean mass than women.
Men were more active than women at each transition except for parenthood.
Men were more likely to be set aggressive targets than women ( P = 0.026 ) .
Men were more likely to favor competitive and exercise-oriented activities , and they associated healthy aging with mobility and physical activity.
Men were rated as having more difficulties on the HCD , but not the LCD , factor compared to women.
Men were younger and more physically active than women.
Men who planned to continue working were particularly likely to have a spouse wanting to work past the age of @number@
Men who responded were screened by telephone to ascertain eligibility.
Men whose scars cannot be easily hidden due to baldness are good candidates as well.
Men who were newly diagnosed of OSA and CPAP therapy naïve were recruited in a tertiary teaching hospital.
Men with 6-month history of ED and in monogamous heterosexual relationships were included.
Men with advanced age at surgery and non-Caucasians were at increased risk of morbidity and mortality.
Men with a head injury had higher mean amyloid plaque counts in the neocortex and entorhinal cortex than men without.
Men with CV risk factors showed positive association of CMR T1 indices of myocardial fibrosis with age.
Men with ED were identified within a study cohort of @number@ men with T2D.
Men with erectile dysfunction ( IIEF-5⩽20 ) had improved erectile function with testosterone treatment.
Men with FT deficiency had higher W and Cr levels and lower Fe.
Men with higher social support and a higher income reported significantly higher mental health.
Men with low AFTC and low bio-17β-E2 levels had lower cortical density and thickness at both skeletal sites compared with the reference group.
Men with low education had a more than threefold risk of being a smoker ( OR @number@ CI @number@.58-7.51 ) .
Men with lower educational attainment and from a non-professional background were more likely to retire early through disability.
Men with no major chronic diseases who were in the highest ferritin quartile had a significantly increased risk of cardiovascular mortality.
Men with Patient Health Questionnaire ( PHQ-9 ) scores greater than or equal to @number@ were deemed to be clinically depressed.
Men with peripheral fractures had poor bone microarchitecture.
Men with premature ejaculation were excluded from this analysis.
Men with sexual dysfunction ( poor sexual performance , decreased morning erection , and loss of libido ) had significantly greater CVD risk.
Men with the relatively stable , lower BMI trajectory had significantly better outcomes than those with trajectories with accelerated increases , especially those including obesity.
Men with TT deficiency had significantly lower concentrations of Mg and Fe and increased Mn.
Men with vertebral fractures had poor bone microarchitecture.
Men wore a GT3x accelerometer over the hip for @number@ days.
Meperidine was also associated with an increased risk of delirium compared with other opioids , whereas tramadol was not.
MEPs increased in all conditions , except the older adult's receiving sham.
MEP variability was strongly modulated by resting motor threshold but not by age.
Mercury is an environmental toxicant that causes numerous adverse effects on human health and natural ecosystems.
Merely living in a nursing home reduces the level of physical activity.
Merely observing another person performing an action can make young people later misremember having performed this action themselves ( the observation-inflation effect ) .
Merits of the NPI include being comprehensive , avoiding symptom overlap , ease of use , and flexibility.
Merits Van der Klink et al's definition of SE ( @number@ ) has three important merits.
Mesenchymal and skeletal stem cell populations in the autograft are activated by L-WNT3A and mitotic activity and osteogenic differentiation are significantly enhanced.
Mesenchymal stem cells are the precursors for both adipocytes and osteoblasts.
Mesenchymal Stem Cells derived from Amniotic Fluid ( AFMSCs ) are multipotent cells of great interest for regenerative medicine.
Mesenchymal stem cells ( MSC ) are postnatal progenitor / stem cells that possess multilineage mesodermal differentiation capacity , including toward SkM.
Mesenchymal stem cells ( MSC ) raise high hopes in regenerative medicine.
Mesenchymal stem cells ( MSCs ) are in the center of attention of many investigators due to easy isolation from many tissues.
Mesenchymal stem cells ( MSCs ) contribute to tissue repair in vivo and form an attractive cell source for tissue engineering.
Mesenchymal stem cells ( MSCs ) have been shown to possess immunomodulatory properties.
Mesenchymal stem cells ( MSCs ) have been used in cell-based therapy for various diseases , due to their immunomodulatory and inflammatory effects.
Mesenchymal stem cells ( MSCs ) home to the injury site and reduce fibrosis by secreting multifunctional antifibrotic humoral factors in IPF.
Mesenchymal stem cells ( MSCs ) play important roles in the hematogenesis of bone marrow.
Mesenchymal stem cells ( MSCs ) play pivotal roles in regenerating bones after bone injury.
Mesenchymal stem cells ( MSC ) were isolated from human umbilical cord and cultured in vitro.
Mesenchymal stem cells were injected directly into the lesion following laminectomy and durotomy.
Mesenchymal stem / stromal cells ( MSCs ) have emerged as novel therapeutic agents with promising results in experimental studies of HIE.
Mesenchymal stroma cells were isolated from bone of differently aged healthy donors.
Mesenchymal stromal cells ( MSC ) were isolated through mechanical and enzymatic digestion from amniotic membranes and were evaluated for specific mesenchymal stromal cells antigens.
Mesial temporal sclerosis ( MTS ) is the most common cause of drug-resistant temporal lobe epilepsy in adults.
Mesotherapy with hyaluronic acid ( HA ) is a treatment approach currently used for skin rejuvenation.
Message framing-the way in which a message is presented-is an important consideration in the dissemination of information to promote changes in health behaviour.
Messages describing how best to age are prominent in gerontological theory , research and the media.
Mesterolone significantly improved Aging Male Symptoms , International Prostate Symptom and prostate-related quality of life scores ( p < 0.001 ) .
Meta-analyses of cohort-specific logistic regression on asthma incidence were performed.
Meta-analyses of proportions were used to combine data.
Meta-analyses report that calcium supplementation reduce bone loss by @number@.5-1.2% and the risk of fracture of all types by at least @percent@ in older people.
Meta-analyses suggest that T treatment plus PDE5i yielded more effective results in noncontrolled versus controlled studies.
Meta-analyses using random effects models were performed to estimate pooled hazard ratios.
Meta-analyses were conducted , and adherence levels were reported as the relative risk of non-adherence in older individuals compared to younger individuals.
Meta-analyses were conducted for four polymorphisms using random effects models , of which three ( APOE , BDNF , SLC6A4 ) were associated with LLD.
Meta-analyses were conducted using random effects models with Review Manager ( RevMan ) computer software.
Meta-analyses were conducted using Stata @number@ software.
Meta-analyses were performed to compare the mean difference in BASMF and the standardized mean difference in RASMF between older and young groups.
Meta-analyses were undertaken for the primary outcomes : emotional status , functional status , self-efficacy and social participation.
Meta-analysis assessed exercise-associated DNA methylation change.
Meta-analysis demonstrated advancing paternal age association with increased risk of autism across studies.
Meta-analysis found that patients with delirium were older than those without delirium ( OR @number@ p < 0.001 ) .
Meta-analysis identified @number@ articles ( @number@ genes / 1580 individuals ) associated with exercise.
Meta-analysis including @number@ previously screened AD cohorts confirmed the association of p.R47H with AD ( p = @number@.93×10 ( @number@ ) ) .
Meta-analysis of proportional hazards models from the four cohorts was used to determine the association between Δage and mortality.
Meta-analysis of published studies reporting an association of LDD features and VFx was performed.
Meta-analysis of RCTs suggests that GH treatment for persons with or at risk for developing osteoporosis results in very small , nonsignificant increases in BMD.
Meta-analysis of the discovery and replication studies ( n = @number@ ) was performed on the top SNPs from GOLDN.
Meta-analysis of the published series with ours suggests presence of heterogeneity ( Breslow-Day p < @number@ ) .
Meta-analysis of this allele in > @number@ subjects from our and published series showed a suggestive protective effect ( p = @number@ ) .
Meta-analysis random-effects models were applied.
Meta-analysis results are consistent with a polygenic model of inheritance.
Meta-analysis revealed that MSCs have a significant positive effect on neurobehavioral outcome following HIE injury.
Meta-analysis showed that @number@ of the above prominent sSNPs were previously investigated in association with various pathological conditions.
Meta-analysis was conducted using Comprehensive Meta-analysis.
Meta-analysis was not conducted , because of the heterogeneity of the study designs , interventions and outcome measures.
Meta-analysis was performed if three or more studies measured the same outcome.
Meta-analysis was performed using signed differential mapping.
Meta-analysis was performed using the data from four currently available studies.
Meta-analysis was performed with data from the Utrecht Cardiovascular Pharmacogenetics study.
Metabolically generated H2O2 emerged from recent research as a central hub in redox signaling and oxidative stress.
Metabolically healthy obese ( MHO ) individuals seem to be protected against those complications.
Metabolic and functional analyses revealed an impaired glucose metabolism in senescent cells.
Metabolic changes could lead to differences in dissolved oxygen in brain tissue , leading to T1 shortening.
Metabolic complications and other conditions responsible for increased cardiovascular risk are common in HIV persons.
Metabolic cost of movements during @number@ h was also calculated.
Metabolic data suggest some benefit in the lipid profile , improvement in bone mineral density and reduced bone reabsorption.
Metabolic derangements , such as obesity , oxidative stress , dyslipidemia and atherosclerosis may be considered confounding factors with regard to nephrosclerosis.
Metabolic disease ( @percent@ ) was the most prevalent comorbidity followed by renal ( @percent@ ) and cardiovascular disease ( @percent@ ) .
Metabolic disorders are associated with decreased TS levels in aging men.
Metabolic disorders include some rare entities , such as mucinosis and amyloidosis , but also commoner manifestations such as xanthelasma.
Metabolic disturbance is remarkable in patients with HF.
Metabolic intervention influences both intracellular ATP concentration and ATP : ADP ratio , where subtler changes may be detected by the latter.
Metabolic investigations showed transient methylmalonic aciduria , and genetic testing of the peripheral blood identified the c.1824C > T heterozygous LMNA mutation.
Metabolic process of MSCs differentiation and the putative interplay of SIRT1 and AMPK in this process was also discussed.
Metabolic reprogramming has emerged as a common feature of cancer.
Metabolic risk factors and aging were independently associated with high BP prevalence as were low educational level and alcohol consumption.
Metabolic risk factors and exercise self-efficacy were evaluated for all subjects before and after @number@ months of home-based exercise.
Metabolic risk mediated the effects of age on FA and RD change in corpus callosum body and dorsal cingulum.
Metabolic syndrome and psychological factors are highly prevalent in aging men , and might be other important determinants of erectile dysfunction.
Metabolic syndrome data were assessed at an invited visit and metabolic syndrome was defined by the National Cholesterol Education Program's Adult Treatment Panel-III criteria.
Metabolic syndrome increases the risk of developing cardiovascular diseases , hypertension and type-2 diabetes , among other diseases.
Metabolic syndrome is a cluster of cardiovascular risk factors defined by the presence of abdominal obesity , glucose intolerance , hypertension and / or dyslipidemia.
Metabolic syndrome is associated with a low-grade , chronic inflammation , primarily in adipose tissue.
Metabolic syndrome is characterized by multiple risk factors and is associated with increased risk of diabetes and cardiovascular disease.
Metabolic syndrome is extremely prevalent in the world and can be considered as one of main factors leading to accelerated aging and premature death.
Metabolic syndrome ( MetS ) has become a health and financial burden worldwide.
Metabolic syndrome ( MetS ) has been found to be a risk factor for dementia , mild cognitive impairment , and its associated states.
Metabolic syndrome ( MetS ) is a clustering of cardiovascular risk factors which places individuals at increased risk for cardiovascular morbidity and mortality.
Metabolic syndrome ( MetS ) is a clustering of vascular risk factors and is associated with increased risk of cardiovascular disease.
Metabolic syndrome ( MetS ) is a constellation of cardiometabolic abnormalities that commonly occur together and increase risk for cardiovascular disease and type II diabetes.
Metabolic syndrome ( MetS ) is an important risk factor for CVD.
Metabolic syndrome ( MetS ) is associated with the development of type @number@ diabetes mellitus ( T2DM ) , as well as other unfavorable outcomes.
Metabolic syndrome ( MetS ) is a syndrome that involves at least three disorders dyslipidemia , insulin resistance , obesity and / or hypertension.
Metabolic syndrome ( MS ) is widespread in the human population , and its incidence is continuously increasing , generating serious health problems.
Metabolic syndrome ( MS ) was defined accordingly.
Metabolic syndrome was defined according the National Cholesterol Education Programme ( NCEP-ATP III ) .
Metabolic syndrome was defined according to National Cholesterol Education Program-Adult Treatment Panel III ( NCEP-ATPIII ) criteria.
Metabolic syndrome was defined according to the Adult Treatment Panel ( ATP ) III criteria.
Metabolic syndrome was defined based on the Japanese criteria.
Metabolic syndrome was defined by four sets of criteria.
Metabolic syndrome was not associated with cIMT.
Metabolism of β-amyloid peptide ( Aβ ) is closely associated with the pathology and etiology of Alzheimer's disease ( AD ) .
' Metabolism ' refers to the vast collection of chemical processes that occur within a living organism.
Metabolite concentrations normalised to unsuppressed water were quantified using LCModel and associations between age and spinal cord metabolite concentrations were examined using multiple regressions.
Metabolite levels , respiration and insulin secretion were examined in human islets.
Metabolites involved in the cellular membrane are prominently affected and may be useful biomarkers of the RBC storage lesion.
Metabolomics analysis based on quadrupole time-of-flight mass spectrometry was conducted to examine the differences in compounds from urine.
Metabotropic glutamate receptors @number@ and @number@ ( mGluR2 / 3 ) have been shown as efficient targets for antipsychotic intervention.
Metacarpal cortical thickness is used as a measure of cortical bone status.
Metacognitive measures revealed sensitivity to the processing advantage of spaced study and to differences in classification difficulty across categories.
Metal cations have been recognized as playing important roles in stabilizing G-quadruplex , but their binding processes to human telomeric G-quadruplex remain uncharacterized.
Metal dyshomeostasis in the brain ( BMD ) has often been proposed as a possible cause for several neurodegenerative disorders ( NDs ) .
Metal implants are often secured to the tibial plateau by a mantle of poly ( methyl methacrylate ) bone cement.
Metallothionein ( MT ) is a low molecular weight protein with anti-apoptotic properties that has been demonstrated to scavenge free radicals in vitro.
Metallothioneins are conserved cysteine-rich proteins that function as efficient ROS scavengers and may affect longevity.
Metals are essential for normal CNS functioning , and metal imbalances have been linked to demyelination and neurodegeneration.
Metaphase II cumulus-free oocytes ( n = @number@ ) were selected for confocal microscopy observations.
Metaphase nuclei were analyzed for chromosomes showing PCD , X chromosomes with PCD ( PCD , X ) , and acrocentric chromosomes showing PCD.
Meta-regression analysis revealed that there was an association between renal function and the amount of calcium reduction under treatment with cinacalcet.
Meta-regression and subgroups analyses were used to explore potential sources of between-study heterogeneity.
Meta-regression models were fitted for all @number@ countries together to investigate the relationship between CIFLE and education in men and women at age @number@
Meta-regression revealed that study type was not a significant source of between-study heterogeneity.
Meta-regression showed LV end diastolic diameter as a significant determinant of variation for LS.
Meta-regression to assess heterogeneity by several covariates and subgroup analysis on ARC types were performed.
Meta-regression was applied to explore the effect of BMI and age on morning blood and urinary free cortisol levels.
Meta-regression was used to explore potential sources of between-study heterogeneity.
Metastasis is the major cause of treatment failure in cancer patients and of cancer-related deaths.
Metastatic colorectal cancer ( mCRC ) is the third leading cause of cancer deaths worldwide.
Metastatic colorectal cancer ( mCRC ) , like many cancers , is primarily a disease of elderly people.
Meta-synthesis was conducted on the data within the found papers.
Metazoans have evolved ways to engage only the most appropriate cells for long-term tissue development and homeostasis.
Metformin and rapamycin are two FDA-approved mTOR inhibitors proposed for this purpose , exhibiting significant anti-cancer and anti-aging properties beyond their current clinical applications.
Metformin and sulfonylureas were the oral antidiabetics ( OADs ) most frequently used as monotherapy.
Metformin directly bound to the C-terminal acidic tail of HMGB1.
Metformin has a molecular weight of @number@ Daltons and therefore readily crosses the placenta.
Metformin has been widely used for over @number@ decades.
Metformin has utility in cancer prevention and treatment , though the mechanisms for these effects remain elusive.
Metformin increases lifespan and prevents cancer in mice , although its effects vary , depending on mice strain and gender.
Metformin is also known to have numerous nonglycemic effects.
Metformin is noted for its beneficial effects on lifespan extension and on disorders due to increased insulin resistance.
Metformin now has a variety of clinical applications in pediatrics , and its potential clinical uses continue to expand.
Metformin was included in > 60% of the combination regimens with metformin + sulfonylurea being the most common.
Methionine can be oxidized by reactive oxygen species to a mixture of two diastereomers , methionine-S-sulfoxide and methionine-R-sulfoxide.
Methionine sulfoxide reductases ( Msr's ) are key enzymes proficient in catalyzing the reduction of oxidized methionines.
Methionine sulfoxide reductases ( Msrs ) , MsrA and MsrB , are the enzymes responsible for this system.
METHOD.
METHOD : 3D reconstructions were performed in @number@ cases aged between @number@ and @number@ years in whom no abnormality influencing lower limbs biomechanics was observed.
METHOD : A approach was conducted.
METHOD : A community-based , convenience sample of Spanish institutionalised and non-institutionalised elders voluntarily participated in this cross-sectional study.
METHOD : A community-based participatory research approach was implemented to partner with the Chicago's Chinese community.
METHOD : A comparative case law methodology was used.
METHOD : A comprehensive , electronic review of the literature was performed.
METHOD : A comprehensive literature search identified studies that satisfied the pre-set inclusion and exclusion criteria.
METHOD : A computerized database search from @date@ to @date@ was conducted using the search terms Amish and cardiovascular.
METHOD : A cross-sectional correlation study was employed.
METHOD : A cross-sectional design was used.
METHOD : A cross-sectional design was used to evaluate the ARISE prototype against other HAS.
METHOD : A cross-sectional design was used with @number@ community-dwelling participants aged @number@ and older.
METHOD : A cross-sectional sample of @number@ participants ( age range 18-85 years ) was used to investigate this question.
METHOD : A cross-sectional study of @number@ community-dwelling Korean older adults was conducted from @date@ to @date@ .
METHOD : A cross-sectional study was conducted.
METHOD : A dual-task paradigm was used to objectively evaluate the listening effort of @number@ young and @number@ older adults.
METHOD : Adults ( N = @number@ ) with and without SBM completed working memory span and manipulation tasks , and an inhibitory control task.
METHOD : A first sample of @number@ cognitively normal participants was recruited in the memory clinic of Broca hospital between @number@ and @number@
METHOD : After adhering to inclusion and exclusion criteria , a total of eight studies were included in the present review.
METHOD : Age group differences and correlations with age were examined , as were associations among age , sensory processing , and cognition.
METHOD : Aging , male Mexican American IDUs ( N = @number@ ) were recruited through intensive outreach.
METHOD : A Glaserian grounded theory design was used to conduct this retrospective study to yield a substantive middle-range theory.
METHOD : A grounded theory methodological approach was utilized.
METHOD : A lexical task was conducted involving recognition and naming of famous people from photographs.
METHOD : A literature review of dementia with Lewy bodies , Alzheimer's disease , and Parkinson's disease with dementia was conducted using PubMed.
METHOD : A literature review was conducted using EBSCOhost and included the databases CINAHL , MEDLINE , and PsycINFO.
METHOD : A literature search was conducted to retrieve studies of the past @number@ years.
METHOD : A literature search was conducted utilising PsychInfo , Cochrane Reviews , Web of Science , Medline and British Humanities Index databases.
METHOD : All articles discussing the psychometric properties and factor structure of the NPI were searched for in Medline via Ovid.
METHOD : All individuals were enrolled in the Neurological Disorders in Central Spain , a population-based epidemiological study in central Spain.
METHOD : A longitudinal , analytic and prospective study was implemented in @number@ residential care homes for seniors.
METHOD : A mixed-method research design was employed.
METHOD : A mixed-methods study was conducted.
METHOD : A Monte Carlo simulation is used to illustrate the variance in outcomes that can be expected for a hypothetical individual.
METHOD : A multi-stage cluster sample of @number@ residents aged @number@ or more was investigated from @number@ communities in Shanghai , China.
METHOD : Analyses used retrospective and current data from the Midlife Development in the United States ( MIDUS ) study.
METHOD : Analyses were conducted using a selected subsample of the HRS / AHEAD data set.
METHOD : Analysis of medical records of @number@ people with dementia recruited by @number@ family practices in NW London and surrounding counties.
METHOD : An a priori review protocol was developed ; @number@ of @number@ articles retrieved in the search were deemed eligible for review.
METHOD : A nationally representative sample of @number@ Mexican Americans aged @number@ to @number@ was analyzed.
METHOD : A national survey of @number@ Swedish nursing homes ( 2013-2014 ) .
METHOD : A national survey was sent to all registered GPs in the Maltese islands.
METHOD : A nationwide , register-based cohort study.
METHOD AND MATERIALS : Twenty healthy volunteers wore a specific appliance.
METHOD : An ethnographic case study was conducted in an urban community in the province of New Brunswick between @date@ and @date@ .
METHOD : A newly developed questionnaire assessing domain-specific age stereotypes was administered to a large sample of adults covering a wide age range.
METHOD : An experimental , pre-intervention postintervention control group design was used in this study.
METHOD : An expert panel developed two procedures for physical activity counselling in the primary care setting.
METHOD : An initial systematic database search identified @number@ potential studies.
METHOD : An innovative strategy , didactic readers theater , was piloted.
METHOD : An observational study was conducted in an outpatient setting in Ontario , Canada.
METHOD : An observational study was conducted in nursing homes on volunteers aged 70-90 years.
METHOD : A non-clinical cohort ( n = @number@ ) provided qualitative data about well-being strategies.
Method : : a people-centered care partnership model was developed on the basis of qualitative meta-synthesis of the literature and assessment of @number@ related projects.
METHOD : A phenomenological approach was used to explore the experiences of re-engaging in leisure occupations post-stroke.
METHOD : A population of @number@ hospitalized elderlies was asked to execute several classical clinical tests evaluating their risk of falling.
METHOD : A postal-based cross-sectional survey was carried out with @number@ GP practices randomly selected using the Irish College of General Practitioners database.
METHOD : A pre-test and post-test was administered to participants , and all data were collected and archived to measure knowledge gained.
METHOD : A prospective cohort / cross-sectional study was designed.
METHOD : A prospective randomized control trial was conducted in six nursing homes in northern Taiwan.
METHOD : A prospective study from @date@ to @date@ .
METHOD : A prospective study was conducted.
METHOD : A qualitative approach and the principles of narrative research were used to learn as much as possible about the individuals ' stories.
METHOD : A qualitative explorative study design was used.
METHOD : A qualitative multiple case study design was applied.
METHOD : A qualitative study based on a sample of @number@ certified social workers.
METHOD : A randomised controlled trial ( RCT ) was employed.
METHOD : A randomized controlled trial design was conducted from in @number@ in a community centre in Hong Kong.
METHOD : A randomized control trial ( RCT ) recruits and randomly assigns @number@ MWC users ( 55 + years ) .
METHOD : A randomly selected one-third of Wave @number@ participants and their spouses or coresident partners were invited to participate in the sleep module.
METHOD : A retrospective analysis was conducted of @number@ patients with TBI who were administered the WPTAS during hospital admission.
METHOD : A review and interpretation was conducted based on public documents , community consultations , survey analyses , and participant observation.
METHOD : A review of the literature focused on the three-dimensional study of facial aging was carried out.
METHOD : A review of the literature was undertaken relating to borderline personality disorder ( BPD ) , personal responsibility and competency.
METHOD : Articles on elder abuse from @number@ to @number@ were reviewed.
METHOD : A sample consisting of @number@ Chinese caregivers for frail elderly spouses was recruited from home care services across various districts in Hong Kong.
METHOD : A sample of @number@ informal caregivers of dependent elderly people - @number@ primary and @number@ secondary caregivers - was obtained.
METHOD : A sample of @number@ participants aged @number@ or older was drawn from the national Aging , Demographics , and Memory Study.
METHOD : A sample of @number@ ( @percent@ female ) older adults living in a large metropolitan area participated in this study.
METHOD : A sample of @number@ workers answered a web-survey questionnaire that collected information about socio-demographics , health , work characteristics and work ability.
Method : A sequential nonword repetition task was used to examine learning over @number@ days.
METHOD : A single-group repeated measures design was used ( N = @number@ ) .
METHOD : Assessment of forearm position sense for a 10-degree reference position in @number@ young adults who were healthy.
METHOD : A standard guideline was used for translation and cultural adaptation of the English version of the TFI into Polish.
METHOD : A survey was conducted with a convenience sample of HCAs in three long-term care settings in the Republic of Ireland.
METHOD : A systematic literature review was performed.
METHOD : A systematic literature search for qualitative research papers was undertaken in @date@ .
METHOD : A systematic literature search of PubMed was performed , focused on the risk factors for institutionalization.
METHOD : A systematic literature search was conducted , identifying @number@ studies.
METHOD : A systematic review of the literature on HS and dementia was conducted up till @date@ .
Method : A systematic search involving Web of Science , PsyINFO , PsychARTICLE , and MedLine databases and Google Scholar was performed.
METHOD : A systematic search of the literature published from @number@ onwards was conducted in the Pubmed and EMBASE databases.
METHOD : A total of @number@ individuals were randomly assigned to take part in MIP + TTC or MIP alone.
METHOD : A total of @number@ interviews were conducted with African-American elders endorsing at least mild symptoms of depression.
METHOD : A total of @number@ participants in the National Health and Nutrition Examination Survey ( 1999-2004 ) provided self-report information on oral health.
METHOD : A total of @number@ patients were treated with PCD in a tertiary care referral center over a 6-year period.
METHOD : A total of @number@ young and @number@ older participants were included in the extension analysis.
METHOD : A training program for informal caregivers of people with dementia was developed.
METHOD : A two-group comparison design was implemented.
METHOD : Australian old age psychiatrists were purposively sampled and interviewed in-depth.
METHOD : A validated 136-item food frequency questionnaire was used to assess the adherence to the MedDiet at baseline.
METHOD : Baseline serum FGF21 levels were measured in @number@ Chinese type @number@ diabetic subjects recruited from the Hong Kong West Diabetes Registry.
METHOD : BP was measured automatically in middle-aged subjects and with a mercury sphygmomanometer in the oldest old.
METHOD : Brief questionnaires were sent to all elderly care physicians in the Netherlands.
METHOD : By using avatars , participants interacted via real-time chat in a virtual environment in an 8-week support group.
METHOD : Caregivers of AD outpatients were semi-randomly allocated to one of two intervention programmes ( CBT or EDUC ) consisting of eight weekly sessions.
METHOD : Care home residents were invited to join gender-based groups ( i.e. Ladies and Gentlemen's Clubs ) .
METHOD : Cognitive decline was determined by Montreal Cognitive Assessment ( MoCA ) .
METHOD : Cohort simulation modelling.
METHOD : Consecutive patients were randomly allocated to a model development sample or a model validation sample.
METHOD : Convenience samples of @number@ adults ≥65 were interviewed.
METHOD : Cross-sectional analyses of @number@ community-dwelling men and women aged 75-90 living in Central Finland in @number@
METHOD : Cross-sectional analytical study with @number@ elderly women from a local community in the Federal District , Brazil.
METHOD : Cross-sectional study conducted at a movement disorders outpatient clinic.
METHOD : Cross-sectional study of two cohort of individuals with and without steatosis , with assessment of several clinical and laboratory variables.
METHOD : Cross-sectional survey carried out across East Sussex in the UK based on a self-administered postal questionnaire.
METHOD : Data are drawn from the Wisconsin Longitudinal Study , a sample of nearly @number@ healthy White Midwestern high school graduates in their mid-60s.
METHOD : Data are from the Family Ties and Aging Study ( @number@ ) .
METHOD : Data are from the @number@ National Health and Aging Trends Study ( N = @number@ ) .
METHOD : Data are from the @number@ Social Environment and Biomarkers of Aging Study , a nationally representative survey of older adults in Taiwan.
METHOD : Data are from the Survey of Mid-Life in the United States ( MIDUS ) , a national sample of middle-aged and older adults.
METHOD : Data came from a cross-sectional survey conducted in four low-income public rental housing estates in Hong Kong in @number@
METHOD : Data came from a national representative survey including @number@ respondents aged @number@ and older.
METHOD : Data came from @number@ adults , interviewed up to four times between @number@ and @number@
METHOD : Data come from @number@ waves of the Health and Retirement Study ( 1996-2008 ) .
Method : Data come from the National Longitudinal Survey of Youth @number@ a nationally representative sample of individuals born between @number@ and @number@
METHOD : Data come from the @number@ and @number@ waves of the Health and Retirement Study ( N = @number@ ) .
METHOD : Data come from the Social Environment and Biomarkers of Aging Study in Taiwan and the Midlife in the United States study.
METHOD : Data come from three waves of the Americans ' Changing Lives ( ACL ) study.
METHOD : Data for @number@ eligible older people living in three rural areas were collected.
METHOD : Data for this study came from two interview waves ( T1 and T2 ) of the National Health and Aging Trend Study.
METHOD : Data for this study , consisting of @number@ earthquake survivors , were obtained from a population-based cross-sectional survey conducted in Iran , @number@
METHOD : Data from childhood were refined and mortality data collected for @number@ participants from the Terman Life Cycle Study.
METHOD : Data from @number@ independently living older couples were analyzed using the Actor-Partner Interdependence Model ( APIM ) .
METHOD : Data from @number@ men were pooled from two studies of African American aging.
METHOD : Data from semistructured interviews with seven participants discussed aspects of social isolation or loneliness.
METHOD : Data from six waves ( 1998-2008 ) of the Health and Retirement Study ( HRS ) were pooled.
METHOD : Data include @number@ qualitative interviews with frail , older people living in each setting , collected as part of a larger Welsh study.
METHOD : Data on older adults aged @number@ years or more , with at least two chronic health conditions were drawn from three cohort studies.
METHOD : Data taken from the survey of the Korean Longitudinal Study of Aging in @number@ were analyzed.
METHOD : Data used in these analyses were part of the 2003-2004 National Health and Nutrition Examination Survey ( NHANES ) .
METHOD : Data were analysed using qualitative content analysis.
METHOD : Data were collected and analyzed using constructivist grounded theory.
METHOD : Data were collected from a cross-sectional survey of @number@ elderly Korean immigrants ( age ≥ @number@ ) in Los Angeles County.
METHOD : Data were collected from family caregivers ' self-completed questionnaires from @date@ to @date@ .
METHOD : Data were collected from @number@ Appalachian older adults ( M = @number@ range 70-94 years ) .
METHOD : Data were derived from the baseline survey of the Korean Longitudinal Study of Aging.
METHOD : Data were drawn from the @number@ National Intellectual Disability Database and the Census in Ireland.
METHOD : Data were drawn from the Resources for Enhancing Alzheimer's Caregiver Health Study.
METHOD : Data were from the Health and Retirement Study , waves 1998-2010.
METHOD : Data were obtained from five waves of the Health and Retirement Study.
METHOD : Data were obtained from the @number@ California Health Interview Survey ( CHIS ) .
METHOD : Data were taken from a longitudinal study of health and aging that included @number@ young older adults aged 55-70 years.
METHOD : Data were taken from a national survey that sampled the community-dwelling Jewish population aged 65-94 in Israel.
METHOD : Data were used from the Longitudinal Aging Study Amsterdam ( LASA ) .
METHOD : Design cross-sectional , population-based survey.
METHOD : Dyadic multilevel modeling of data ( N = @number@ non-Hispanic couples ) from @number@ to @number@ of the Health and Retirement Survey.
METHOD : ECG was used to measure R-R interval , Finapres to measure ABP and capnography to measure end-tidal CO₂.
METHOD : Eighteen older and @number@ young adults searched for a predesignated target within 24-degree visual arrays containing distractors.
METHOD : Eighteen participants ( aged @number@ to @number@ ) were assigned to three age-stratified 90-minute focus groups.
METHOD : Elderly outpatients ( N = @number@ ) were recruited in 2011-2012 by convenience sampling from three randomly selected medical centers in Taiwan.
METHOD : Electronic databases and reference lists of included studies ( up to @date@ ) were systematically searched.
METHOD : Electronic databases ( MEDLINE , CINAHL , EMBASE , and PsycINFO ) were searched for studies published between @number@ and @date@ .
METHOD : Eleven elderly high-rise buildings were used.
Method error was evaluated with kappa statistics and Bland-Altman ( BA ) plots.
METHOD : Exploratory and confirmatory factor analyses were performed to assess the factor structure of frequency and limitation sub-scales of the LLDI.
METHOD : Feldenkrais Method Awareness Through Movement lessons were transcribed and the contents were analysed.
METHOD : Fifty-five older adults were randomly assigned to an experimental group or an active control ( AC ) group.
METHOD : Fifty-seven older people benefited from a geriatric assessment including clinical and functional evaluations to include only those without gait disorders.
METHOD : Findings from a variety of sources were used to summarize gender differences in antipsychotic treatment.
METHOD : Five databases were searched from inception to @date@ to include randomized control trials and comparative observational English studies.
METHOD : Five-year trajectories of memory , reasoning , visual processing speed / useful field of view , digit-symbol substitution , and vocabulary were investigated.
METHOD : Focus groups , written surveys , and data recording sheets were used with nine older people and five physiotherapists.
METHOD : For this cross-sectional study , the sample comprised @number@ elders with dementia and their family caregivers ( FCs ) .
METHOD : Forty-eight healthy older adults ( age range = 60-77 years ) completed @number@ of @number@ versions of a computerized Corsi block test.
METHOD : Forty-five patient-proxy pairs participated in the study.
METHOD : Forty-two participants with dementia diagnosed before the age of @number@ completed measures of emotional and cognitive functioning and six SVTs.
METHOD : Fourteen healthy men ( @number@.4±6.3 years ) underwent cardiopulmonary exercise testing ( CPX ) on a cycle ergometer until physical exhaustion.
METHOD : From the @number@ National Social Life , Health , and Aging Project , @number@ cases were examined.
Method : Groups of patients with aMCI and cognitively healthy control participants ( N = @number@ each ) provided short spoken and written language samples.
METHOD : Healthy older adults completed a series of mental status examinations.
METHOD : Human chondrocytes were isolated from the articular cartilage of femoral heads , obtained with ethical permission , following fractured neck of femur surgery.
METHOD : Hybrid concept analysis , our research design , utilizes both theoretical analysis of literature and empirical observation to define a concept.
METHOD : In a cross-sectional study , @number@ older adults with osteoarthritis of the knee were assessed at baseline and two-years ' follow-up.
METHOD : In a cross-sectional study , @number@ visually impaired elderly persons completed telephone interviews.
METHOD : In all , @number@ Copenhagen Aging and Midlife Biobank ( CAMB ) participants received a clinical oral examination that included number of teeth.
METHOD : In all , @number@ elderly ( 65-101 years , @number@ men ) patients hospitalised in an acute medical unit participated.
METHOD : In an open pilot trial ( N = @number@ ) , home-based providers delivered DCM to participants.
METHOD : In Experiment @number@ R-SPIN sentence lists were matched on context , target-word length , and median word segment length necessary for target recognition.
METHOD : In-hospital patient information was routinely collected by multidisciplinary staff and entered into a database.
METHOD : In @number@ experiments , younger and older adults with normal hearing listened to and identified vocal emotions in the TESS stimuli.
METHOD : Internal consistency was assessed by the Cronbach's α coefficient and inter-item correlations.
Method : Interviewees were chosen based on their physical function and well-being scores.
METHOD : In the Vision-Hearing Project , @number@ participants ( 65 + years ) completed interviews and a hearing test at low-vision clinics.
METHOD : In this article , the author reports on both cross-sectional and longitudinal changes in listening comprehension.
METHOD : In this prospective cohort study , data were retrieved from the Taiwan Longitudinal Study on Aging from @number@ to @number@
METHOD : In total , @number@ aMCI patients and @number@ healthy older adults participated in a recognition test followed by remember / know judgments.
METHOD : LEP was measured in @number@ non-institutionalized participants with the Short Physical Performance Battery ( SPPB ) .
METHOD : LiLACS NZ is a longitudinal study.
METHOD : Logistic regression models were used with data from the Mexican Health and Nutrition Survey , @number@
Method : Longitudinal data of adults aged @number@ years and older of the German Ageing Survey was used ( N = @number@ ) .
Method : Machine learning techniques modeled stigmatization expressed in @number@ AD-related tweets collected via Twitter's search API based on @number@ AD-related keywords.
METHOD : MEDLINE , EMBASE and The Cochrane Library Database were used to identify potential studies.
METHOD : Memory sets of @number@ @number@ or @number@ faces were presented , which were followed by a probe after a 3-s retention interval.
METHOD : Meta-analysis of observational studies , no randomized controlled studies were available.
METHOD : Mixed methods - including a focus group , household interviews , daily diaries and collection of meteorological data.
METHOD : Ninety-three older people living in four long-term care homes in south-western Germany were included in this longitudinal cohort study.
METHOD : Non-systematic literature review.
METHOD : NSHAP developed its measures by modifying traditional short-form scales to improve response efficiency and reduce respondent burden.
METHOD : @number@ centenarians and near-centenarians ( @number@ years and older ) of the Georgia Centenarian Study participated in this research.
METHOD : @number@ individuals with aMCI were compared with @number@ healthy older adult controls on a story learning task.
METHOD : @number@ patients ≥60 years of age were recruited from @number@ GP clinics within Singapore.
METHOD : @number@ young , @number@ middle-aged , and @number@ older adults participated in Experiment @number@
METHOD OF STUDY : Anti-Müllerian Hormone ( AMH ) levels were analyzed in @number@ HIV-infected and @number@ uninfected participants using left-censored longitudinal models.
METHOD : Older adults with either age-normal hearing or mild-to-moderate sensorineural hearing loss performed a running memory task.
Methodological and theoretical consequences for extant theories of mental simulation are discussed.
Methodological and theoretical Grounded Data Theory and Symbolic Interaction were used , respectively.
Methodological issues and complexities in analyzing and selecting datasets were highlighted.
Methodological issues limited the interpretation of several studies.
Methodological issues within this study make it highly likely that the real burden of OA has been underestimated.
Methodologically , there is also debate about whether beverages should be included in dietary ED calculations.
Methodologically , this means that many studies may have omitted an important potential confounder.
Methodologically , this study textually analyzed @number@ different international older persons ' human rights documents.
METHODOLOGICAL QUALITY : Each primary study was assessed by two independent reviewers for methodological quality.
Methodological quality of the studies was modest.
Methodological quality was appraised with the CASP tool.
Methodological quality was assessed using one of two scales dependent on study design.
METHODOLOGIC APPROACH : Qualitative analyses of interview transcripts to identify common themes.
METHODOLOGIC APPROACH : Semistructured , individual interviews.
Methodologic issues presently preclude knowing with certainty whether or not aging in the absence of cognitive impairment is necessarily associated with lower brain glucose metabolism.
Methodologies for measurements of vascular markers need to be further standardized and less operator-dependent.
METHODOLOGY : A cross-sectional study was conducted on @number@ elderly patients ( @number@ years and older ) recruited from Meet Abbad-Nabaroh-Dakahlia , Egypt.
METHODOLOGY : All @number@ Medicare- and Medicaid-certified nursing homes in Indiana were surveyed between August and @date@ .
METHODOLOGY AND SAMPLE : A quasi-experimental study including a usual care and experimental phase with hospitalized English-speaking patients aged @number@ years and older.
METHODOLOGY : A retrospective survey was performed on @number@ cases of MRSA infections from inpatient , outpatient and nursing home populations over a 12-month period.
METHODOLOGY : blood serum concentrations of retinol and β-carotene of @number@ morbidly obese individuals were assessed.
METHODOLOGY : Cohorts were obtained from the Medicare Current Beneficiary Survey linked to Medicare claims data.
METHODOLOGY : Cross-sectional data on @number@ nationally representative nursing homes were derived from the @number@ National Nursing Home Survey.
METHODOLOGY : data obtained from a prospective observational cohort study ( 2008-2012 ) of @number@ community-dwelling persons in Belgium aged @number@ and older.
METHODOLOGY : Five manuscripts were considered eligible for this review.
Methodology for noninvasive in vivo assessments is still under development.
METHODOLOGY : @number@ adults , both sexes , the average age was @number@ years for patients and @number@ years for respondents.
METHODOLOGY : Of a total of @number@ patient files evaluated @number@ cases were flawless , of which the study factors were recorded.
METHODOLOGY : Patients admitted to ICU for severe influenza between @date@ , and @date@ , were identified and their medical records were retrospectively reviewed.
METHODOLOGY / PRINCIPAL FINDINGS : A systematic review and meta-analysis on the P300 was performed including @number@ studies ( n = @number@ ) .
METHODOLOGY / PRINCIPAL FINDINGS : Human hepatic stellate cell line , LX-2 cells , were cultured and stimulated with SEA.
METHODOLOGY / PRINCIPAL FINDINGS : In this study we report glycation of human serum albumin ( HSA ) & its characterization by various spectroscopic techniques.
METHODOLOGY / PRINCIPAL FINDINGS : Larvae of Ae. aegypti were collected in central Guadeloupe and breed under laboratory conditions until adult emergence.
METHODOLOGY / PRINCIPAL FINDINGS : Sixteen young adults completed the prospective and retrospective metamemory questionnaire , providing individual subjective judgments of everyday memory function.
METHODOLOGY / PRINCIPAL FINDINGS : To asses DNA damage accumulation and repair capacities , γH2AX-foci were examined before and after exposure to ionizing irradiation.
METHODOLOGY / PRINCIPAL FINDINGS : Two age groups conducted two tasks with different stimulus response mappings and task difficulty.
METHODOLOGY / PRINCIPAL FINDINGS : We found that silencing WRN accelerated the proliferation of HL60 cells and decreased the cell growth rate of TK6 cells.
METHODOLOGY / PRINCIPAL FINDINGS : We have traced Aβ accumulation quantitatively in the ageing mouse retina using immunohistochemistry and Western blot analysis.
METHODOLOGY / PRINCIPAL FINDINGS : We recruited @number@ observers with normal vision across the age span ( age 21-85 ) .
METHODOLOGY : Published studies using PubMed ( © ) database @number@ - @number@ have been analyzed.
METHODOLOGY : SAMPLE : @number@ Italian participants.
METHODOLOGY : The Achilles ' tendon was cut and the enthesis destroyed.
METHODOLOGY : The sample included @number@ healthy sedentary males , scheduled for inguinal hernia surgery , aged @number@ to @number@ y.
METHODOLOGY : This is a quantitative study , of the non-experimental , descriptive , cross-sectional type attended by @number@ Portuguese elderly.
METHODOLOGY : This UK based prospective longitudinal cohort study recruited @number@ preterm children born at a tertiary neonatal unit during @number@ and @number@ matched controls.
METHODOLOGY : Three thousand six hundred nine DONs completed leadership and intent-to-quit surveys.
METHODOLOGY : We considered a human protein interaction network and two paradigmatic cluster recognition algorithms , namely : the Clauset-Newman-Moore and the infomap procedures.
METHODOLOGY : We validated a specific evaluation with a control group ( @number@ healthy subjects ) .
METHOD : One hundred and eight participants who met general criteria for MCI were included for the purposes of this study.
METHOD : One hundred and forty-eight elderly women ( 65-85 years ) participated in this study.
METHOD : One hundred ninety-eight alcohol-dependent patients at the beginning of alcohol withdrawal therapy were included in this study.
METHOD : Our sample consisted of @number@ healthy , nondemented adults aged between @number@ and @number@ years.
METHOD : Out of @number@ donations to a population-based study , @number@ brains were selected where donors had no dementia measured in life.
METHOD : Over @number@ psychiatric outpatients were evaluated with semi-structured diagnostic interviews.
METHOD : Pairs of stimuli were shown to healthy elderly people and to patients with moderate and mild Alzheimer's disease.
METHOD : Participants aged @number@ years and over were recruited from @date@ to @date@ .
METHOD : Participants consisted of @number@ adults aged ≥ @number@ yr from the NHANES study.
METHOD : Participants included community-dwelling children and adults ( N = 367 , ages 3-85 yr ) across seven sites.
METHOD : Participants included @number@ community-dwelling older adults ( 65-85 years ; mean age = @number@ years ; @percent@ female ) .
METHOD : Participants included @number@ older men referred by their primary care providers for a behavioral health assessment at a Veterans Affairs Medical Center.
METHOD : Participants ( N = @number@ ) were from the Advanced Cognitive Training for Independent and Vital Elderly ( ACTIVE ) study.
METHOD : Participants ( n = @number@ ) with dementia were administered the Standard NAT , a performance-based test requiring completion of three everyday tasks.
METHOD : Participants were assessed on measures of executive functioning , health-related quality of life ( HRQoL ) and social functioning.
METHOD : Participants were drawn from three waves of the Health and Retirement Study.
METHOD : Participants were from the nationally representative longitudinal Health and Retirement Study.
METHOD : Participants were @number@ adolescents ( age @number@ years at the first assessment ) and their primary caregivers.
METHOD : Participants were @number@ community-dwelling adults , age @number@ or older.
METHOD : Participants were @number@ older adults enrolled in theChicago Health and Aging Project ( CHAP ) , a population-based study of older adults.
METHOD : Participants were @number@ older adults ( @percent@ men , ages 54-83 ) free of major medical , neurologic , and psychiatric disease.
METHOD : Participants were @number@ patients with mild cognitive impairment or dementia , recruited through UCSF's Memory and Aging Center.
METHOD : Participants were @number@ people , ages @number@ to @number@ years , in good health , who lived in their homes.
METHOD : Participants were @number@ younger ( mean age = @number@ years ) and older adults ( mean age = @number@ years ) .
METHOD : Participants were @number@ younger ( M = @number@ years ) and @number@ older ( M = @number@ years ) healthy adults.
METHOD : Participants were randomly assigned into an experimental or control group.
METHOD : Participants were recruited for the Baltimore Study of Black Aging - Patterns of Cognitive Aging.
METHOD : participants were recruited from an older person's medical ward.
METHOD : Participants were selected from the population-based SNAC-K study.
METHOD : Patients in phase III of cardiac rehabilitation were divided into high and low cardiovascular fitness groups based on their predicted peak VO2.
METHOD : Patients with FXTAS and their caregivers seen during @date@ to @date@ participated.
METHOD : Personal memoire in which the author conjures up powerful images of contrasting healthcare systems and the tension of living in two countries.
METHOD : Postal survey responses from a representative population sample of New Zealanders aged @number@ to @number@ years ( N = @number@ ) .
METHOD : Proposed competencies were derived from existing hospice and palliative medicine fellowship competencies and revised to be developmentally appropriate for students and residents.
METHOD : Prospective follow-up , @number@ residents ( median age @number@ years , @percent@ women ) from census-type survey ( @date@ ) ; @number@ facilities.
METHOD : Qualitative interviews were conducted with @number@ hospitalized older adults.
METHOD : Qualitative interviews with @number@ people aged 49-61 who were in contact with voluntary sector drug treatmentservices.
METHOD : Quantitative and qualitative data on anemia were collected from participants aged ≥50 years from @date@ to @date@ using questionnaires and in-depth interviews.
METHOD : Recent research and current thinking about age-related declines in cognition and the links between auditory and cognitive aging are reviewed briefly.
METHOD : Recent studies implicating sex hormones and other natural hormones in the modulation of hearing status in age-related hearing loss were reviewed.
METHOD : Relevant longitudinal observational studies were identified by systematically searching Ovid Medline , EMBASE , and ISI Web of Knowledge databases.
METHOD : Respondents reported anger expression via survey assessments and completed an overnight clinic visit.
METHOD : Retrospective review of patients undergoing rejuvenation by a single surgeon between @number@ and @number@
METHOD : Review of current literature on the subject.
METHOD : Review of the literature on Pubmed with the following keywords \ "Poliomyelitis \ " and \ "Post-Polio Syndrome ( PPS ) \ ".
METHOD : Rogers and Knafl's evolutionary method of concept analysis was used.
METHOD : Rogers and Knafl's evolutionary method of concept analysis was used.
Methods.
METHODS : .
METHODS.
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METHODS.
METHODS A 10-year retrospective study of all the patients who were treated in the authors ' hospital between @number@ and @number@ was conducted.
METHODS : A 12-week observational longitudinal study of hypogonadal men was conducted as part of the original HIS-Q psychometric evaluation.
METHODS : A 12-week , single center , clinical study was conducted on @number@ women with mild to moderate photodamage.
METHODS : A 2014-2015 cross-sectional survey of hospices nationwide.
METHODS : A 24-week randomized , controlled trial of @number@ elderly women with knee OA.
METHODS : A 3½-h oral glucose tolerance test was performed in eleven trained and ten untrained , young , healthy men.
METHODS : A 6-month ancillary study within a multicentre randomized trial.
METHODS : A 9-month prospective study was performed among patients referred for vascular-type claudication.
METHODS : AADS-I was administered to professional carers of @number@ aging ID individuals.
METHODS : AAM ( N = @number@ ) enrolled in Medicare and participating in a longitudinal study on patient navigation were surveyed.
METHODS : A birth cohort ( n = @number@ ) in rural Kenya , was studied intensively to monitor infections and describe age-related serological characteristics.
METHODS : A birth cohort of @number@ adults , with data at birth , age @number@ and @number@ years was used.
METHODS : Absolute male world records of @number@ events were collected along with world records of male Masters categories.
METHODS : A care coordination ontology was built based on activities extracted from @number@ notes labeled with the Omaha Case management category.
METHODS : A case-control design study was performed.
METHODS : A case-control study nested within a population-based cohort.
METHODS : A case study approach included both qualitative and quantitative components.
METHODS : A chart review , cross-sectional survey , and examination were performed.
METHODS : A clinical study was performed in two phases of @number@ days each.
METHODS : A cluster-randomized trial and a mixed-methods approach.
METHODS : A cohort case-control study was conducted in a 37-bed medical ward at a tertiary medical centre in Israel.
METHODS : A cohort of @number@ hypertensive patients and @number@ normotensive individuals matched for age and gender were enrolled in this study.
METHODS : A cohort of @number@ normotensive and @number@ untreated hypertensive participants with baseline ABPM was drawn from a community-based survey.
METHODS : A cohort of @number@ patients with type @number@ diabetes enrolled in @number@ participated in a teambased self-management intervention with followup in @number@
METHODS : A cohort of @number@ women was interviewed during early pregnancy.
METHODS : A cohort of people aged ≥50 years was selected from the English Longitudinal Study of Ageing.
METHODS : A cohort study of acutely admitted medical patients aged @number@ or older.
METHODS : A combined analysis of two claims databases was conducted.
METHODS : A community-based interventional study was conducted in selected areas in Kattankulathur Block , Kanchipuram District , Tamil Nadu , India.
Methods : A comprehensive review of the literature regarding the use of platelet rich plasma in aesthetic surgery was performed.
METHODS : a comprehensive search of the peer-reviewed literature using four electronic databases.
METHODS : A consecutive sample of @number@ elderly patients ( age≥65 ) with AKI in a university hospital was enrolled.
METHODS : A contrasting group framework was used to compare discussions in two sets of focus groups with relatively healthy and less healthy older adults.
METHODS : A controlled sentence production task was combined with digital pursuit rotor tracking.
METHODS : A convenience sample of @number@ dementia patients according to DSM-IV-TR criteria and @number@ healthy participants was selected.
METHODS : A convenience sample of @number@ middle-aged women was selected from the community.
METHODS : A convenience sample of @number@ older adults completed @number@ BP measurements and PA questionnaires.
METHODS : A criterion measure to assess physical independence was identified.
METHODS : A cross-sectional analysis in antiretroviral-treated HIV-positive patients aged @number@ years and older.
METHODS : A cross-sectional analysis of a population-based sample of California adults responding to the @number@ California Health Interview Survey.
METHODS : A cross-sectional analysis of wave @number@ data from the Irish Longitudinal Study on Ageing was undertaken.
METHODS : A cross-sectional analysis was conducted of data from @number@ participants of the Aragon Workers Health Study cohort.
METHODS : A cross-sectional comparative design was conducted in a university motion analysis laboratory.
METHODS : A cross-sectional comparison of standing postural sway in healthy TC-naïve and TC-expert ( @number@.5±12 yrs experience ) adults.
METHODS : A cross-sectional design compared @number@ long-distance runners exhibiting EHMC to @number@ non-active controls.
METHODS : A cross-sectional design of Finnish caregivers ( n = 1117 ) .
METHODS : A cross-sectional design was used , and @number@ senior male veterans were convenience sampled from three veterans ' homes in southern Taiwan.
METHODS : A cross-sectional , exploratory study was conducted.
METHODS : A cross-sectional opinion survey was conducted in Hong Kong and @number@ participants were interviewed.
METHODS : A cross-sectional questionnaire survey of consecutive adult patients with moderate to severe psoriasis was conducted.
METHODS : A cross-sectional research design was executed.
METHODS : A cross-sectional sample of @number@ participants from four rural counties in the People's Republic of China was included in this analysis.
METHODS : A cross-sectional study examining the relationship between t'ai chi practice and age- , gender- and education-similar older peoples ' attention and memory functions.
METHODS : A cross-sectional study in an Emergency Department.
METHODS : A cross-sectional study including @number@ participants with @percent@ response rate.
METHODS : A cross-sectional study in @number@ current smokers and @number@ non-smokers was conducted.
METHODS : A cross-sectional study involving @number@ participants was conducted in six Australian RACFs.
METHODS : A cross-sectional study of consecutive geriatric patients aged ≥60 years with NVAF who discharged from our hospital between @date@ and @date@ were collected.
METHODS : A cross-sectional study of elderly people was conducted in Garrucha ( Almería ) in southern Spain.
METHODS : A cross-sectional study of functioning and disability in male Vietnam-era Veteran twins.
METHODS : A cross-sectional study of @number@ children and adolescents aged 5-18 years from the Jirel ethnic group in eastern Nepal was performed.
METHODS : A cross-sectional study of @number@ FC-geriatric patient dyads was conducted.
METHODS : A cross-sectional study of @number@ self-reported stroke survivors from the @number@ National Health and Aging Trends Study was performed.
METHODS : A cross-sectional study of @number@ volunteers stratified by gender and age was completed.
METHODS : A cross-sectional study of patients presenting to a single urban academic medical center between @date@ and @date@ .
METHODS : A cross-sectional study using two-stage probabilistic sampling recruited @number@ individuals aged @number@ years and above.
METHODS : A cross-sectional study was carried out from April to @date@ .
METHODS : A cross-sectional study was carried out in Salvador , Brazil , with a sample of @number@ individuals ≥20 years of age.
METHODS : A cross-sectional study was conducted.
METHODS : A cross-sectional study was conducted.
METHODS : A cross-sectional study was conducted.
METHODS : A cross-sectional study was conducted among @number@ consenting Uyghur elderly in @number@ in six randomly selected communities / villages in Xinjiang.
METHODS : A cross-sectional study was conducted among @number@ nurses from two general hospitals in Israel ( @percent@ female ) .
METHODS : A cross sectional study was conducted among @number@ old men.
METHODS : A cross-sectional study was conducted , enrolling @number@ community-dwelling and @number@ hospital-checkup elderly Han Chinese males aged ≥50 years.
METHODS : A cross-sectional study was conducted in @number@ men ( aged 40-79 years , mean age @number@ years ) .
METHODS : A cross-sectional study was conducted in three community settings in Japan from autumn to winter.
METHODS : A cross-sectional study was conducted on @number@ subjects aged 45-60 years from the SU.VI.MAX cohort.
METHODS : A cross-sectional study was conducted with @number@ healthy students ( @number@ boys , @number@ girls ) .
METHODS : A cross-sectional study was conducted with @number@ outpatients aged @number@ years or older with COPD.
METHODS : A cross-sectional study was performed including @number@ subjects from the EVIDENT trial ( mean age @number@.9±13.7 years ; @percent@ women ) .
METHODS : A cross-sectional study was performed in @number@ vertically HIV-infected patients.
METHODS : A cross-sectional study was performed on @number@ women aged @number@ to @number@ years in health checkup centers between @date@ and @date@ .
METHODS : A cross-sectional study was performed using injury registry data from the Kurume City Fire Department , Japan.
METHODS : A cross-sectional study with @number@ elderly people of both genders.
METHODS : a cross-sectional survey targeted patients and staff members delivering exercise interventions for reducing falls.
METHODS : A cross-sectional survey was carried out among @number@ Buddhist community-dwelling older adults aged ≥60 years in Nakhon Pathom , Thailand.
METHODS : A cross-sectional survey was undertaken in three ambulatory hospital clinics for musculoskeletal disorders.
METHODS : A cross-sectional telephone survey was undertaken of @number@ Australians aged 20-75 years.
METHODS : A cross-sectional three-group comparison of @number@ patients ( 65 + ) presenting at family medicine surgeries in Germany was performed.
METHODS : A demonstration project was introduced in an independent retirement community to validate our theoretical framework of informatics and wellness assessment for older adults.
METHODS : A descriptive cross-sectional study design was used.
METHODS : A descriptive ecological study was carried out.
METHODS : A descriptive , exploratory online survey research design was utilized.
METHODS : A descriptive review of anatomic changes in the eye related to aging was performed in the context of current areas of investigation.
METHODS : A detailed cross-sectional survey questionnaire on successful aging was completed by @number@ older women.
METHODS : A deterministic mathematical model has been developed in order to obtain aging projections for the nursing workforce from @number@ until @number@
METHODS : Adhering to the Systematic Review Protocol for Animal Intervention Studies , a systematic search of English articles was performed.
METHODS : Administrative data relating to medical visits were linked to @number@ primary care facilities over a period of @number@ years.
METHODS : Administrative health data from the home care sector were linked to hospital administrative data to carry out the analyses.
METHODS : A DNA methylation assay using bisulfite pyrosequencing technology was performed on @number@ Uygur and @number@ Han Chinese individuals from Xinjiang province , China.
METHODS : A double-blind , randomized , active drug-controlled , phase III study with @number@ enrolled subjects was performed.
METHODS : A double-blind , randomized controlled trial examined whether laninamivir octanoate was noninferior to oseltamivir.
METHODS : A double-blind , randomized , placebo-controlled clinical trial was conducted by an independent esthetic clinic on @number@ healthy volunteer subjects for @number@ days.
METHODS : A double-blind , randomized study was carried out on @number@ women who had a long-term history of RVVC with mild to moderate symptoms.
METHODS : AD patients received four high-frequency rTMS sessions over the bilateral dorsolateral prefrontal cortex ( DLPFC ) over two weeks.
METHODS : Adult patients hospitalized for first-ever ischemic stroke between @number@ and @number@ were identified from a nationwide administrative database.
METHODS : Adults aged @number@ years and older with diagnosed or self-reported dyslexia were participants in a web-based survey.
METHODS : Adult survivors of childhood cancer and siblings , all participants of the Childhood Cancer Survivor Study , completed three surveys assessing health status.
METHODS : A finite-element model for oxygen transport and consumption in the human vitreous was created.
METHODS : A follow-up study of screening colonoscopy participants in 2007-2009 in Saarland , Germany , was conducted using health insurance claims data.
METHODS : A four-month prospective , non-randomised , controlled study was performed.
METHODS : After excluding the presence of pathogenic mitochondrial DNA mutations , whole-exome sequencing of blood DNA from the index patient was performed.
METHODS : After extraction , samples were analysed by ultra-performance liquid chromatography-tandem mass spectrometry and 17-hydroxyprogesterone was quantified accurately.
METHODS : After pre-treatment with @number@ pMKlotho for @number@ h , HUVECs were stimulated with @number@ μg / ml ox-LDL for @number@ h.
METHODS : After screening , @number@ subjects aged 60-90 were found to be qualified.
METHODS : After the cornea and iris were removed , a @number@ to @number@ mm anterior CCC was created.
METHODS : A full medical history was obtained for @number@ euthymic BD and @number@ healthy comparison ( HC ) individuals.
METHODS : Aged Wistar rats were administered with Heshouwuyin.
Methods : A genome-wide association study of parental life span in participants of European and African ancestry from the Health and Retirement Study was conducted.
METHODS : A health state transition model was developed-based on Hoehn and Yahr ( HY ) stages in PD-to compare the two treatment strategies.
METHODS : A historical cohort study in the German statutory health insurance system was conducted.
METHODS : A hybrid study design will evaluate the effectiveness and implementation strategy of Eat Walk Engage in a real-world setting.
METHODS : A in Padua ' public tertiary level Centre was conducted.
METHODS : A label-free quantitative proteomics approach was applied to study secretomes of subcutaneous and omental preadipocytes from obese subjects.
METHODS : A laboratory experiment was conducted with people age @number@ to @number@ years split by gender into four age groups.
METHODS : A large database including serum thyroid tests drawn in community clinics was studied.
METHODS : A limited number of approved therapeutic molecules are available to activate bone formation.
METHODS : A literature review was performed along with the analysis of cross-references.
METHODS : A literature review was performed to identify all published , randomized controlled trials ( RCTs ) of testosterone treatment for hypogonadism.
METHODS : A literature review was performed to identify relevant papers on straylight and pseudophakia with no patient comorbidities.
METHODS : A literature review was undertaken to determine the incidence of CI-AKI in individuals receiving intravascular contrast medium in the hospital setting.
METHODS : A literature search of Medline , CINAHL and the Internet ( Google ) was undertaken.
METHODS : A literature search was performed to review the clinical and pathologic phenotypes and family history associated with each FTLD gene.
METHODS : A literature search was performed using PubMed.
METHODS : A literature search was undertaken to identify and taxonomize prevailing policies worldwide.
METHOD : Saliva from passive drool was collected from returning Wave @number@ respondents and non-respondents as well as their partners during an in-home interview.
METHODS : Alkaline phosphatase immunohistochemistry was performed using polyclonal antibodies against CRP and CFH on cryopreserved tissue sections from disc / macular blocks.
METHODS : All children below the age of @number@ years who received clonidine during ECMO were eligible.
METHODS : All consecutive , low energy open ankle fractures treated at a Level I Trauma Centre over a five-year period were included.
METHODS : All consecutive patients with imaging-confirmed ischemic stroke admitted to our tertiary care hospital from @date@ to @date@ were registered prospectively.
METHODS : All data was obtained from the @number@ National Study of Caregiving ( NSOC ) .
METHODS : All eyes underwent swept source optical coherence tomography ( OCT ) , and choroidal images were binarized into blood vessels lumen and stroma.
METHODS : All HIV-infected 21-year-olds engaged in care ( 2002-2011 ) at the HIV Research Network clinics were included.
METHODS : All hospital admission records between @date@ and @date@ were retrospectively analyzed.
METHODS : All @number@ @number@ members of the population-based Swedish Twin Registry born @number@ to @number@ with alcohol data aged ≤60 years were included.
METHODS : All @number@ patients from the DANISH study were included in this prespecified subgroup analysis.
METHODS : All participants received usual CVD prevention and a guideline-based educational program.
METHODS : All participants were screened through the nationwide Danish National Hospital Register.
METHODS : All patients ( @number@ adult and @number@ elder patients ) received the implantation of PPM.
METHODS : All patients who underwent PD were identified in the 2005-2012 NSQIP Participant Use File.
METHODS : All patients with TLHIs in the setting of DISH between @date@ and @date@ were reviewed retrospectively.
METHODS : All publications of the two journals were viewed.
METHODS : all volunteers had their body composition assessed by dual-energy x-ray absorptiometry.
METHODS : ALM , gait speed , and grip strength were assessed seven times over @number@ years in @number@ initially well-functioning adults aged 70-79.
METHODS : A longitudinal and prospective study was carried out in @number@ singleton pregnancies ( @number@ low-risk pregnancies and @number@ with essential hypertension ) .
METHODS : A longitudinal population-based study of menopausal status is currently underway in a city in South Brazil.
METHODS : A longitudinal study over @time@ ( ±1.46 ) months including @number@ community-dwelling older adults across @number@ regions in Taiwan was undertaken.
METHODS : ALS researchers worldwide were invited to participate in a detailed online survey to determine their attitudes and practices relating to genetic testing.
METHODS : A Markov model was designed to simulate a cohort of @number@ VTE patients receiving either apixaban or LMWH / VKA.
METHODS : Ambulant patients with cancer admitted to palliative care services were recruited.
METHODS : A messaging statement was developed using the AGREE-II instrument as guidance.
METHODS : A meta-analysis of prevalence of medication non-adherence using the double arcsine square root transformed proportion was undertaken.
METHODS : A meta-analysis was conducted on the association between the IL-6 polymorphism and knee OA.
METHODS : A mixed method design was used.
METHODS : A mixed methods approach was adopted.
METHODS : A mixed-method sequential explanatory design was used , including a quantitative and a qualitative component with a clinical research design.
METHODS : A mixed-methods study used an interview-guided theory-based survey of professional women aged @number@ to @number@ years.
METHODS : A model-based economic evaluation ( decision tree ) using the US Medicare perspective and a conservative annual temporal framework was conducted.
METHODS : A modified Timed Up And Go task was used since it is comprised of these activities , all performed in a continuous fashion.
METHODS : Among @number@ home-dwelling men , aged 60-85 ( mean @number@ ) years , lifestyle and health status were evaluated through a questionnaire.
METHODS : Among subjects from a prospective cohort study of ILD , elderly was defined as age ≥ @number@ years.
Methods A monocentric prospective clinico-pharmacological study included stage IIIb / IV NSCLC consecutive pts. treated with erlotinib.
METHODS : A monocentric , prospective controlled trial was undertaken at the geriatric wards of a large university hospital.
METHOD : Sample included @number@ community-dwelling elders ( @number@ women ; M Age = @number@ years , SD = @number@ ) .
Method : Samples of African Americans , Caribbean blacks , and non-Hispanic whites aged 55 + were drawn from the National Survey of American Life.
METHODS : A multicenter prospective surveillance for COP was conducted from @date@ to @date@ in Japan.
METHODS : A multicenter retrospective analysis was conducted in prospective registries of patients treated by thrombolysis within @number@ hours of stroke onset.
METHODS : a multi-component delirium prevention intervention that targeted delirium risk factors was implemented by clinical staff.
METHODS : A multilevel , cross-sectional study was conducted in @number@ in Bogotá Colombia.
METHODS : A multinational patient registry was used to assess long-term changes associated with TRT in middle-age and older men with hypogonadism.
METHODS : A multinomial logit framework was adopted to predict two-level injury severity using collision data between @number@ and @number@
METHODS : A multiple-case study approach was used.
METHODS : A multiwave cohort study repeated every @number@ years and data linkage to records from retirement registers.
METHODS : An 8-day daily diary study was conducted in @number@ on @number@ men aged 58-88.
METHODS : An age cross-sectional study was conducted in @number@ healthy adult women excluded from diseases and drugs affecting bone metabolism.
METHODS : An age-stratified random sample of @number@ subjects ≥ @number@ years was selected in O Salnés ( Spain ) .
METHODS : Analyses are based on data of several population-based cohorts of long-term breast cancer survivors , recruited by six German cancer registries.
METHODS : Analysis included @number@ DONALD participants with parental reported data on sleep duration and annually measured body composition until age @number@
METHODS : Analysis of the current literature regarding the epidemiology , clinical features , and pathogenesis of iERM and fibrotic tissue contraction.
METHODS : Analysis was based on the NAHSIT 1999-2000 dataset.
METHODS : Analytical cross-sectional study with @number@ subjects.
METHODS : Analytical quantitative cross-sectional study conducted at a public trauma hospital located in Fortaleza-Ceará , Brazil.
METHODS : An analysis of an existing prospective cohort study of @number@ community living older adults followed over a five-year time frame.
METHODS : An analysis of baseline data was conducted from a treatment study including @number@ adults age @number@ and older.
METHODS : An analytical cross-sectional study was conducted in two private gastroenterology clinics on biopsy proven patients suffering from NASH.
METHODS : An analytic cross-sectional study was carried out among the GDPs in @number@
METHODS : A national cross-sectional survey yielded data from @number@ Australians aged 20-22 , 30-32 and 40-42 years ( response rate @percent@ ) .
METHODS : A nationally representative sample of @number@ adults from the NHANES ( 2003-2006 ) was used as the study population.
METHODS : A nationally representative , Swedish , level of living survey from @number@ was used as baseline.
METHODS : A nationwide survey of older Mexican Americans was conducted ( N = 1 , 005 ) .
METHODS : A nationwide survey was conducted using data from the Taiwan National Health Insurance Research Database from @number@ to @number@
METHODS : Anatomical magnetic resonance images were acquired from @number@ adolescent and adult female subjects with BN and @number@ healthy age-matched control subjects.
METHODS : An audit of routinely collected data regarding @number@ acute ECT courses in @number@ public aged psychiatry services in Victoria , Australia.
METHODS : An automated multi-site algorithm was used to parametrize the alpha rhythm in @number@ healthy subjects aged 6-86 years.
METHODS AND ANALYSIS : FAST is a cardiovascular safety study using the prospective , randomised , open , blinded endpoint design.
METHODS AND ANALYSIS : The study includes @number@ home-dwelling men and women ( 62-70 years ) .
METHODS AND DESIGN : A retrospective observational cohort study was undertaken.
METHODS AND DESIGN : Using a cold-pursuit design , potential subjects are identified from medical claims , hospital discharge summaries and death certificates.
METHODS AND FINDINGS : A multicentre , prospective , longitudinal study of older people in the UK was linked to a brain donation programme.
METHODS AND FINDINGS : A qualitative exploratory design using thematic analysis was used.
METHODS AND FINDINGS : @number@ individuals over @number@ years were included.
METHODS AND FINDINGS : To address this question , we developed a continuous-time , stochastic , individual-based simulation model for influenza transmission.
METHODS AND FINDINGS : Two-sample MR was undertaken using genome-wide association ( GWA ) study data.
METHODS AND FINDINGS : We examined the effects of RJ oral administration on dry eye in this prospective , randomized , double-blind , placebo-controlled study.
METHODS AND FINDINGS : We selected @number@ participants in the InCHIANTI study ( @number@ women ) .
METHODS AND MATERIALS : A retrospective chart review was conducted for patients treated by the author over @number@ years , beginning in @number@
METHODS AND MATERIALS : A total of @number@ patients received injections.
METHODS AND MATERIALS : Fifty-seven participants reviewed practices and techniques for each identified upper- and mid-face treatment indication.
METHODS AND MATERIALS : Ninety-five of @number@ subjects continued with this optional open-label extension of a split-face , double-blind trial.
METHODS AND MATERIALS : One hundred fifty patients ( predominantly African American ) were enrolled at @number@ sites.
METHODS AND MATERIALS : One hundred participants received treatment with BoNTA or placebo saline in this double-blind randomized placebo-controlled survey.
METHODS AND MATERIALS : One surface sealant and one composite resin ( shades A2-0 , A2 , and YE ) were tested.
METHODS AND MATERIALS : Patients with a history of facial filler treatment were examined using ultrasound in an outpatient setting.
METHODS AND MATERIALS : Sixty subjects were enrolled in a randomized , double-blind , split-face study of LGP-HA and LGP-HA + L for NLF correction.
METHODS AND MATERIALS : The clinical metrics of renal function were analyzed in patients undergoing radiation therapy for high-risk neuroblastoma from @number@ to @number@
METHODS AND MATERIALS : This overview presents the different gel filler types , how they interact with host tissue , and what can go wrong.
METHODS AND MATERIALS : Two thousand thirty-seven MRI scans from @number@ women divided into young , middle-aged , and older groups were screened.
METHODS AND OBJECTIVES : Small Swiss villages with low migration rates will be selected for this study.
METHODS AND OUTCOMES : The primary outcome was a new diagnosis of pressure ulceration within @number@ months of index date.
METHODS AND PROCEDURES : Twenty young children with disabilities , aged 1-3 years , were recruited.
METHODS AND RESULTS : A cross-sectional study design was used.
METHODS AND RESULTS : ADHF was defined as hospitalization for ADHF , confirmed and formally adjudicated by a blinded events committee using standardized protocols.
METHODS AND RESULTS : Aortic pulse wave velocity ( PWV ) and carotid PP were studied in @number@ apparently healthy postmenopausal women.
METHODS AND RESULTS : A systematic search was conducted.
METHODS AND RESULTS : A total of @number@ apparently healthy people ( women : 155 , men : 1220 ) , aged 18-70years were enrolled.
METHODS AND RESULTS : A total of @number@ normal subjects ( mean age , @number@.92±4.0 years ) were investigated on transthoracic echocardiography.
METHODS AND RESULTS : A total of @number@ patients with ischemic heart diseases and @number@ asymptomatic controls were recruited.
METHODS AND RESULTS : A total of @number@ subjects ( 55-80 years ) participating in the Prevención con Dieta Mediterránea randomized trial were genotyped.
Methods and Results Between @date@ and @date@ , six ViV procedures with the Edwards Sapien @number@ THV were performed.
METHODS AND RESULTS : C57 / Bl6 mice were randomized to voluntary running or no running wheel conditions for @number@ weeks.
METHODS AND RESULTS : Characteristics and vital status of all French participants in the Tour de France were collected for the 1947-2012 period.
METHODS AND RESULTS : C-kit-positive hCPCs were isolated from heart biopsy samples of patients undergoing left ventricular assist device implantation.
METHODS AND RESULTS : Combined immunoprecipitation / mass spectrometry identified actin as a new binding partner for Trx-1.
METHODS AND RESULTS : Cross-sectional study.
METHODS AND RESULTS : DNA methylation was estimated using pyrosequencing technology.
METHODS AND RESULTS : HIV therapy with PIs is associated with an increased risk of premature cardiovascular disease.
METHODS AND RESULTS : In a cross-sectional study , we analyzed ECGs of a cohort of @number@ patients with schizophrenia , along with medication use.
METHODS AND RESULTS : In @number@ patients with acute myocardial infarction , MDCT was performed immediately after primary PCI.
METHODS AND RESULTS : MEDLINE ( @number@ to present ) and EMBASE ( @number@ to present ) were last searched on @date@ .
METHODS AND RESULTS : Of the @number@ study patients , @number@ ( @percent@ ) were men.
METHODS AND RESULTS : Our state-of-the-art 1-D model was extended to include turbulence and inertial effects of the flow exiting the left ventricle.
METHODS AND RESULTS : Outpatients with cardiac implantable electrical devices compatible with physical activity analysis with at least @number@ days of data were eligible.
METHODS AND RESULTS : Participants were @number@ subjects from Spanish Mediterranean ( n = @number@ ) and North American ( n = @number@ ) populations.
METHODS AND RESULTS : Patients ( n = 199 ) with @number@ different CHD and documented AF episodes were studied.
METHODS AND RESULTS : Patients were recruited from specialist bronchiectasis and cystic fibrosis clinics.
METHODS AND RESULTS : Prospective data collected for a prespecified economic analysis of the trial were used.
METHODS AND RESULTS : QTc intervals of 12-lead resting electrocardiograms were determined , and trends over time were analyzed using a linear mixed-effects model.
METHODS AND RESULTS : Scientific literature regarding asthma in the elderly population was reviewed.
METHODS AND RESULTS : Serum Cr and eGFR were measured in @number@ women , as a part of @number@
METHODS AND RESULTS : Several studies suggest that long term consumption of dietary polyphenols offers protection against development of neurodegenerative diseases.
METHODS AND RESULTS : The Health , Aging , and Body Composition study is a prospective cohort study of nondisabled adults.
METHODS AND RESULTS : The number of people of advanced age in Kumamoto Prefecture has gradually increased.
METHODS AND RESULTS : The @number@ patients who underwent an electrophysiological study and radiofrequency ( RF ) catheter ablation of AVNRT were enrolled.
METHODS AND RESULTS : The present study retrospectively included a total of @number@ patients receiving successful slow-pathway RF ablation for typical slow-fast AVNRT.
METHODS AND RESULTS : The study involved @number@ active subjects ≥65 years old who exercised regularly.
METHODS AND RESULTS : The study sample comprised @number@ children aged @number@ to @number@ years from @number@ to @number@ National Health and Nutrition Examination Surveys.
METHODS AND RESULTS : The Swedish Heart Failure Registry ( RiksSvikt ) and The Swedish Dementia Registry ( SveDem ) were record-linked.
METHODS AND RESULTS : This study was comprised of a prospective cohort of @number@ @number@ male participants of the Physicians ' Health Study.
METHODS AND RESULTS : Through a microarray approach , we have identified a miR-146a that is progressively modulated in endothelial cells with aging.
METHODS AND RESULTS : Twelve sedentary seniors and @number@ Masters athletes were thoroughly screened for comorbidities.
METHODS AND RESULTS : We first measured plasma MBG levels and performed comprehensive clinical , laboratory , and echocardiographic assessment in @number@ patients with HF.
METHODS AND RESULTS : We included @number@ adults ( aged ≥20 ) from the National Health and Nutrition Examination Survey 1999-2002.
Methods and results : We included seven cohorts of the European study of cohorts for air pollution effects ( ESCAPE ) .
METHODS AND RESULTS : We measured erythrocyte creatine in @number@ HCM patients.
METHODS AND RESULTS : We performed an observational study of @number@ @number@ patients who received new ICD implants from @date@ to @date@ .
METHODS AND RESULTS : We performed a retrospective , observational , single-centre study between @number@ and @number@ based on administrative data.
METHODS AND RESULTS : We present structural and immunohistological analysis of cardiovascular tissues from @number@ children with HGPS who died of myocardial infarction.
METHODS AND RESULTS : We prospectively studied @number@ @number@ men from the Physicians ' Health Study.
METHODS AND RESULTS : We report a case of a patient with he-autoscopic seizures.
METHODS AND RESULTS : We studied @number@ participants in Bambuí City , Brazil , with electrocardiogram ( ECG ) records classified by the Minnesota Code.
METHODS AND RESULTS : We studied @number@ subjects ( mean age @number@ ± @number@ years , @percent@ male ) free of traditional cardiovascular risk factors.
METHODS AND RESULTS : We studied @number@ subjects : @number@ SA and @number@ AC subjects.
METHODS AND STUDY DESIGN : One hundred patients who had been on maintenance hemodialysis were enrolled in this study.
METHODS AND SUBJECTS : The study compared two telephone interventions using a 4-month longitudinal randomized controlled trial.
Methods and subjects used are clinical , neuroradiological , and neuropathological examination ; molecular genetics of MAPT , PGRN , and other relevant genes.
METHODS : An electronic search of @number@ online databases ( Embase , MEDLINE , and HealthSTAR ) was conducted to identify eligible studies.
METHODS : An electronic search was conducted in @number@ databases ( Medline , Scopus , CINAHL and Sportdiscus ) .
METHODS : An epidemiological study of ecological design , combining time-series in the period 1995-2009 , was carried out.
METHODS : A nested case-control study was carried out.
METHODS : A nested case control study was conducted using data from the Long Life Family Study.
METHODS : An expert panel met to select appropriate recommendations for assessment and treatment of cognitive-communication disorders based on available literature.
METHODS : An exploratory , case study design was used.
METHODS : An exploratory , cross-sectional study was carried out on @number@ older adults residing at eldercare facilities in Colima , Mexico.
METHODS : An exploratory qualitative study with semi-structured interviews was carried out and data were collected from @number@ young adults recruited through purposive sampling.
METHODS : An exploratory study was conducted.
METHODS : A NF-κB-derived inhibitor tripeptide ( NF-κB-DVH ) was synthesized based on the sequence of dimerization region of the subunit p65 of NF-κB.
METHODS : An instrumental , collective case study design was used with qualitative interviews of patients in the intervention arm of CHROMED.
METHODS : An interpretive phenomenological analysis perspective was used.
METHODS : An interprofessional team developed the FN protocol.
METHODS : An intervention-based study in education was conducted at the beginning of the first year of a medical course.
METHODS : Annual sex- and age-specific HF rates ( per @number@ population ) were determined and standardized using the Australian @number@ population census.
Methods : an observational , cross-sectional , and analytical study was carried out with a non-probabilistic sample.
METHODS : An observational cross-sectional study took place between February and @date@ at an AIBD tertiary referral centre.
METHODS : An observational study of @number@ geriatric inpatients was carried out.
METHODS : A noncomparative interventional case series was performed.
METHODS : An online review of the PubMed database was performed , searching for the key words.
METHODS : An online search of current and past peer reviewed literature on epigenetic changes with cancer and aging was performed.
METHODS : An online systematic literature search was conducted using MEDLINE , ISI Web of Science , Scopus and SPORTDiscus.
METHODS : A non-sequential fractional ultrapulsed CO₂ laser with specific settings is used in addition to a new computer pattern generator ( CPG ) .
METHODS : Anterior and posterior corneal topography were evaluated using 3-dimensional anterior segment optical coherence tomography.
METHODS : Antioxidant effects of E-AP-SM2001 were determined by measuring free radical scavenging capacity and superoxide dismutase ( SOD ) -like activity.
METHODS : A panel of @number@ known deafness genes was analyzed for mutations by next-generation sequencing ( NGS ) in the index patient.
METHODS : A @percent@ random sample , insured in AARP RESULTS : Among insureds , @percent@ used at least one of the FRD classes.
METHODS : A pilot observational study ( July- @date@ ) was carried out in a Californian memory care facility.
METHODS : A pilot randomized controlled design was used.
METHODS : A pilot study was performed including @number@ healthy volunteers.
METHODS : A point prevalence study of delirium provided the reference-standard ratings for delirium diagnosis.
METHODS : A polysomnographic study was performed in @number@ healthy young ( @number@.1±0.8 years ) and @number@ healthy older subjects ( @number@.9±1.9 years ) .
METHODS : A population-based analysis was performed on a dataset obtained by processing public health administration databases.
METHODS : A population-based cohort of @number@ men @number@ to @number@ years of age was followed from @date@ to @date@ .
METHODS : A population-based cohort study of @number@ people aged @number@ years and over with follow-up measures at @number@ @number@ and @number@ years.
METHODS : A population-based cohort study , using British Columbia claims data ( 2009-2013 ) , assessed ChEI new users aged @number@ and older.
METHODS : A population-based , cross-sectional survey of adults aged over @number@ years was carried out.
METHODS : A population-based prospective cohort study of @number@ community-dwelling individuals 65 + .
METHODS : A population-based sample of @number@ adults aged 72-78 years was assessed.
METHODS : A population-based sample of @number@ Malay adults aged @number@ to @number@ years in Singapore was used for this analysis.
METHODS : A population-representative sample of @number@ adults aged @number@ years and over from Spain was analyzed.
METHODS : Applying nationwide registries , prescriptions of three categories of cardiovascular drugs were followed for all Danish residents from @date@ until @number@
METHODS : Appreciative action research informed the development and evaluation of the project.
METHODS : Approximately @number@ octogenarians , residing in nursing homes , were screened in Ankara , Turkey.
METHODS : A pragmatic randomized controlled trial was conducted in an organization with an established restorative home care service.
METHODS : a pre-post cohort study of the impact of embedding CGA within a large ED in the East Midlands , UK.
METHODS : A pre-test-post-test randomized experimental design was conducted.
METHODS : A prevalence-based , cost-of-illness study was conducted using the @number@ Health Insurance Review and Assessment Service-National Patients Sample ( HIRA-NPS ) data.
METHODS : A process of narrative inquiry was used via repeated interviews with three older women caregivers providing care to family members or friends.
METHODS : A prospective analysis comparing advanced photographic techniques including standard photography , polarized light photography , cross-polarized light photography and ultraviolet light passing photography.
METHODS : A prospective cohort study based on the Copenhagen City Heart Study ( 1991-1993 ) .
METHODS : A prospective cohort study design was used to examine ~2.5 million Medicare patients nationwide.
METHODS : A prospective cohort study including @number@ older men with dementia living in two veterans homes in Taiwan was carried out in @number@
METHODS : A prospective cohort study was undertaken.
METHODS : A prospective cohort study was undertaken of patients aged over @number@ years consecutively admitted to @number@ acute care hospitals in Australia.
METHODS : A prospective cohort study where a baseline cross-sectional survey was followed by a survey @number@ year later.
METHODS : A prospective cross-sectional observational study of hemodialysis patients was conducted in Ireland and England during @number@ and @number@
METHODS : A prospective follow up study was conducted at four nongovernmental organization nursing homes in Penang , Malaysia.
METHODS : A prospective observational case series.
METHODS : A prospective , observational cohort study was nested in the Multicenter AIDS Cohort Study from @date@ - @date@ .
METHODS : A prospective observational study of persons aged 50-69 years was conducted.
METHODS : A prospective observational study was conducted in Beijing , China.
METHODS : A prospective observational study was conducted with @number@ subjects ( ≥ @number@ y old ) admitted to the ICU with severe nosocomial pneumonia.
METHODS : A prospective observational study was performed.
METHODS : A prospective observational study was performed in @number@ hospitals of @number@ Italian Regions.
METHODS : A prospective , randomized , double-blind , placebo-controlled study was conducted in @number@ adults.
METHODS : A prospective randomized split-faced study was done ( n = @number@ ) .
METHODS : A prospective single-occasion observational design was used.
METHODS : A prospective study of adult pneumonia was conducted to investigate the incidence of RP and potential risk factors.
METHODS : A prospective study on patients with lung cancer was conducted in three regions of Quebec , Canada.
METHODS : A prospective study was carried out on @number@ patients.
METHODS : A prospective study was carried out with @number@ elderly inpatients ( mean age : @number@ years old ) .
METHODS : A prospective study was conducted in an acute-care hospital in Moscow , Russia.
METHODS : A prospective study with @number@ years of follow-up in @number@ patients aged 60- @number@ was conducted from @date@ to @date@ .
METHODS : A prospective trial was conducted in @number@ patients with moderate-to-severe active intestinal BD , followed up for @number@ weeks.
METHODS : A prototype decision aid was studied in a two-part survey that collected data from participants before and after they examined the decision aid.
METHODS : A qualitative approach was used.
METHODS : A qualitative method using in-depth interviews was used.
METHODS : A qualitative research design with elements of constructivist grounded theory was used.
METHODS : A qualitative study was conducted which consisted of semistructured interviews with managers of information offices.
METHODS : A quantitative analysis of structured interviews was performed.
METHODS : A quantitative overview was adopted with the use of logistic regression models.
METHODS : A quasiexperimental design was used.
METHODS : A quasi-experimental , mixed methods study was conducted.
METHODS : A quasi-experimental non-equivalent control group design was used , in which participants with reported difficulties in bathing were recruited consecutively from two municipalities.
METHODS : A quasi-experimental , within-subject , longitudinal pretest / posttest design was used.
METHODS : A questionnaire including the Turkish-language APQ-S was administered to @number@ community-dwelling Turkish migrants aged 65-99 years who resided in Rotterdam , the Netherlands.
METHODS : A randomised , cluster controlled trial , stratified over @number@ areas of the Auvergne region in France comparing intervention and control groups.
METHODS : A randomised controlled trial with cross over was conducted.
METHODS : A randomized controlled study was done on men , aged 50-70 years in Klang Valley , Malaysia.
METHODS : A randomized controlled trial was conducted.
METHODS : A randomized controlled trial with blinded assessors and intention-to-treat analysis will be undertaken.
METHODS : A randomized crossover pilot study with blinding of the participants.
METHODS : A randomized , double-blind , parallel-group comparative study design was adopted.
METHODS : A randomized experimental design was used.
METHODS : A randomized , multicenter clinical trial was carried out.
METHODS : A randomized sample of the elderly population of Brescia , Italy , was evaluated ( N = @number@ age ≥65 years ) .
METHODS : A randomized un-blind study was conducted in @number@ older adults aged @number@ years and over at high risk of falling.
METHODS : A random population sample ( n = @number@ ) aged 7-17 from Copenhagen was followed longitudinally for @number@ years with four examinations.
METHODS : A rapid evidence review of the current literature was employed to address the study purpose.
METHODS : Arc-shaped stimuli were presented on a black CRT screen at two locations , in the inferior visual field.
METHODS : A recent systematic review on HZ incidence identified studies that evaluated the temporal effects of HZ incidence.
METHODS : A register-based cross-sectional national study used drug reimbursement data from Finland's Social Insurance Institution ( SII ) .
METHODS : A repeated cross-sectional analysis of population-level dispensing data was conducted from @date@ to @date@ .
METHODS : A representative non-institutionalized random sample of @number@ individuals in Rio Grande do Sul , Brazil , aged ≥60 years , was interviewed face-to-face.
METHODS : A representative sample of @number@ New York City Housing Authority residents aged @number@ or older completed a telephone survey in @date@ .
METHODS : A representative sample of the region population was selected using a double randomization design.
METHODS : A retrospective analysis involving @number@ consecutive patients observed for acute lower limb ischemia between @date@ and @date@ who underwent revascularization was conducted.
METHODS : A retrospective analysis of data from the United Kingdom Collaborative HIV Cohort was carried out.
METHODS : A retrospective analysis of data of patients aged ≥70 years admitted to a palliative care in-patient unit.
METHODS : A retrospective analysis of @number@ men over @number@ was carried out and group comparisons were made.
METHODS : A retrospective analysis of @number@ patients was completed on patients having undergone ThermiTight for submental skin tightening.
METHODS : A retrospective analysis was conducted utilizing the Surveillance , Epidemiology and End Results Program of the National Cancer Institute.
METHODS : A retrospective analysis was performed in all PCI procedures from @date@ until @date@ .
METHODS : A retrospective analysis was performed using the conveyance records reported by staff members of the physician-staffed helicopter.
METHODS : A retrospective case notes review of treated patients over the past @number@ years in one tertiary center constituted our methodology.
METHODS : A retrospective chart audit was conducted of patients admitted to an ABI rehabilitation unit to assess current practices.
METHODS : A retrospective chart review of @number@ subjects undergoing thermistor-controlled subdermal skin tightening via percutaneous radiofrequency was conducted.
METHODS : A retrospective chart review of the senior author's ( R.J.R ) face-lift patients was conducted.
METHODS : A retrospective cohort design was used , utilizing secondary databases available for Ontario home care clients from the years @number@ to @number@
METHODS : A retrospective cohort study involving @number@ patients who entered the LCC at Hull from @date@ to @date@ was conducted.
METHODS : A retrospective cohort study , using multiple electronic databases within the Department of Veterans Affairs.
METHODS : A retrospective database analysis was conducted using a historical cohort design and including data collected between @number@ and @number@
METHODS : A retrospective evaluation of @number@ successive fractionated @number@ , 600-nm CO₂ laser treatments in @number@ patients conducted in a single center.
METHODS : A retrospective file review of patients aged @number@ to @number@ years from the University of Waterloo , Optometry Clinic was conducted.
METHODS : A retrospective monocentric study was conducted over @number@ months at Nice geriatric hospital , which included patients with cobalamin deficiency having received supplementation.
METHODS : A retrospective MRI study of @number@ individuals was performed.
METHODS : A retrospective photographic analysis of @number@ Korean patients who received botulinum toxin for the first time to treat glabellar wrinkles was conducted.
METHODS : A retrospective record review of performance on the three-step Luria test was conducted on @number@ participants from a university-based dementia clinic.
METHODS : A retrospective review of an electronic prospectively maintained database was performed between @date@ and 31 / @date@ .
METHODS : A retrospective review of children undergoing peritoneal catheter placement was performed over a 22-year period.
METHODS : A retrospective review of computerized charts was undertaken for advanced cancer patients in the home-care setting.
METHODS : A retrospective review of @number@ consecutive patients who underwent simultaneous face lift and perioral peel was performed.
METHODS : A retrospective review of @number@ vision screening forms from an ongoing vision screening program in Omaha , Nebraska , was conducted.
METHODS : A retrospective review of patients who had undergone secondary rhytidectomy was performed.
METHODS : A retrospective review was performed for patients @number@ years or older with a c-spine fracture during a 4-year study period.
METHODS : A retrospective , single-center chart review of sarcoidosis cases investigated variables associated with the development of OS.
METHODS : A retrospective study design utilizing a rural health diabetic screening clinic data-base containing observational data from @date@ to @date@ .
METHODS : A retrospective study of @number@ Queensland HIV-infected males on cART was conducted.
METHODS : A retrospective study was carried out on @number@ patients ( @number@ eyelids ) operated on between January of @number@ and January of @number@
METHODS : A retrospective study was conducted of Medicaid claims data ( 2001-2004 ) from eight states , focusing on antiretroviral adherence.
METHODS : A retrospective study was conducted using the Australian Government Department of Veterans ' Affairs administrative claims database.
METHODS : A review of available evidence was conducted.
METHODS : A review of literature on transgender medicine on PubMed over the last five years was conducted.
METHODS : A review of @number@ face-lift patients was performed.
METHODS : A review of some of the key aspects relating to management of this growing population was undertaken.
METHODS : A review of the design and content of the GRS and its use as part of the wider Galderma Harmony Program.
METHODS : Articles containing \ "childhood medulloblastoma \ " and \ "quality of life \ " were identified in PubMed.
METHODS : AR was estimated from individually modelled BMI curves from birth to @number@ years.
METHODS : A sample of healthy participants ( N = @number@ ) carried out the motor tests using MotorBrain on a smartphone.
METHODS : A sample of @number@ adults aged @number@ and older seeking non-emergent ophthalmic care.
METHODS : A sample of @number@ community-dwelling older people , aged ≥60 years , in a Chinese city was included between @date@ and @date@ .
METHODS : A sample of @number@ individuals ( @number@ women ) aged 20-85 years performed an exercise test on a treadmill until exhaustion.
METHODS : A sample of @number@ intervention group participants ( 65-89 yrs ) received weekly group sessions of cognitive stimulation for two months.
METHODS : A sample of @number@ participants age @number@ to @number@ years without frailty or disability at baseline was followed for @number@ years.
METHODS : A sample of @number@ subjects aged @number@ years or order was investigated from four communities in Shijingshan District , Beijing , China.
METHODS : A sample of @number@ subjects ( @number@ living in the community , @number@ living in nursing homes ) was interviewed using standardized instruments.
METHODS : A sampling agency gathered cross-sectional data in @date@ .
METHODS : Asbestos-exposed individuals , with no malignant disease at inclusion , were surveilled for @number@ years with annual measurements of SM and MPF.
METHODS : A scoping review of studies pertaining to secondary conditions after stroke published between @number@ and @number@ was conducted.
METHODS : A search was carried out in Pubmed ( 1977-2012 ) for randomized controlled trials investigating the effectiveness of multidisciplinary multidimensional in-home geriatric assessment.
METHODS : A search was done using multiple electronic databases for studies addressing the relationship between QOL and depression in elders with visual impairment.
METHODS : A search was performed using PubMed to identify original studies published in English from @date@ to @date@ .
METHODS : A Seasonal Autoregressive Integrated Moving Average Model was applied to predict overall mortality expected in 2014-2015 based on that observed in 2000-2013.
METHODS : A secondary analyses of data from a cross-national sample of community residing persons was conducted using @number@ interRAI assessments.
METHODS : A secondary analysis design was used to develop the Home Care Frailty Scale.
METHODS : A secondary analysis of @number@ veteran-caregiver dyads.
METHODS : A secondary analysis of the Mexican National Health and Nutrition Survey ( ENSANUT ) , @number@ was conducted.
METHODS : A secondary analysis was conducted on the Survey of Health and Well-Being of Elders ( SABE ) dataset.
METHODS : A secondary data analysis merging electronic medical records ( EMRs ) with data collected from the Indianapolis-Ibadan Dementia project ( IIDP ) .
METHODS : A second follow-up interview with men who were diagnosed with localized or advanced prostate cancer approximately 18-24 months earlier.
METHODS : A self-report survey was used to assess individuals ' personal characteristics , health knowledge , PHR skills , and activities.
METHODS : A semiquantitative brain atrophy and lesion index ( BALI ) was constructed by adapting existing visual rating scales and validated in @number@ datasets.
METHODS : A series of @number@ subjects with autopsy-proven DLB was studied.
METHODS : A simple , low-cost , wearable device for poststroke rehabilitation progress monitoring was developed based on commercially available inertial sensors.
METHODS : A Simple Visual Reaction Test ( SVRT ) tool was used to measure reaction times.
METHODS : A single-blind randomized controlled trial was conducted.
METHODS : A single-center clinical trial was performed on eighteen volunteer male and female patients with under-eye bags.
METHODS : A single-center , prospective study was conducted in the largest ambulatory cancer center in Singapore.
METHODS : As part of the Care and Construction project in Nova Scotia , Canada , LTCF residents completed an MMSE.
METHODS : As part of the Copenhagen City Heart Study , @number@ healthy joggers and @number@ healthy nonjoggers have been prospectively followed up since @number@
METHODS : As part of the Gutenberg Health study , a population-based cross-sectional study was conducted in the general population of Germany.
METHODS : A standardized comprehensive geriatric assessment was performed.
METHODS : Asthma incidence was prospectively assessed in six European cohorts.
METHODS : A stratified random cluster sample of @number@ community-dwelling older people living alone in Shanghai completed a structured questionnaire through face-to-face interviews.
METHODS : A study of relevant articles was conducted among databases ( MEDLINE , PsycINFO , and EBM Reviews-Cochrane Database of Systematic Reviews ) .
METHODS : A subgroup of participants in the Epidemiology of osteoporosis ( EPIDOS ) study ( N = @number@ ) was followed for @number@ years.
METHODS : A subsample of @number@ participants ( ages 55-85 ) of the large population-based German ESTHER study was included in the study.
METHODS : A subset of @number@ nondemented older adults was drawn from the Einstein Aging Study , a community-based sample from the Bronx , NY.
METHODS : A Survey of Aesthetic and Cultural Health was developed to explore the role of aesthetics before , during and after hospital.
METHODS : A survey on prescribing medications for older patients was mailed to @number@ dentists in New Jersey.
METHODS : A survey was conducted on @number@ long-lived subjects ( aged ≥90years ) .
METHODS : A survey was distributed to residents of the American Urologic Association and queried exposure to ablation and surveillance for SRMs.
METHODS : Asymptomatic CHS participants with interpretable 24-h baseline Holter recordings were included ( n = @number@ ) .
METHODS : A systematic English and French review was conducted using Medline , Embase , Pascal and Cochrane literature.
METHODS : A systematic literature review up to @date@ was conducted using PubMed and ISI Web of Science.
METHODS : A systematic literature review was performed by searching the electronic databases PubMed and Google Scholar.
METHODS : A systematic literature review was undertaken and involved four steps.
METHODS : A systematic literature search was conducted in @date@ across six electronic databases and three trial registries.
METHODS : A systematic literature search was conducted in PubMed , Ovid , Cochrane , and PsycINFO databases.
METHODS : A systematic literature search was conducted of publications dated @number@ to @number@
METHODS : A systematic literature search was conducted yielding studies comparing tonic HRV in AAs and European Americans.
METHODS : A systematic literature search was performed.
METHODS : A systematic online search was conducted on MEDLINE , ISI Web of Science , Scopus , and SPORTDiscus databases.
METHODS : A systematic review of in vitro , animal and human studies involving aging and menopause and immune system was carried out.
METHODS : A systematic review of mixed studies.
METHODS : A systematic review of peer-reviewed research articles from @number@ databases in @number@ fields was carried out in @date@ .
METHODS : A systematic review of publications reporting patients with HHH syndrome was performed.
METHODS : A systematic review of studies involving the use of motion-based technology for human participants living with dementia or MCI was conducted.
METHODS : a systematic review searching @number@ electronic databases from @date@ - @date@ using key search terms.
METHODS : A systematic review was carried out in accordance with PRISMA Statement.
METHODS : A systematic review was conducted of non-medical home and community care services for frail older persons.
METHODS : A systematic review was conducted of studies published in MEDLINE and Cochrane Trials before @date@ .
METHODS : A systematic review was performed resulting in a selection of @number@ studies that assessed both malnutrition and frailty in community-dwelling older adults.
METHODS : A systematic review was performed to identify studies examining home care interventions among adult CKD patients incorporating all outcomes.
METHODS : A systematic search identified seven studies in New Zealand that reported prevalence of H. pylori infection among @number@ participants.
METHODS : A systematic search of Medline , Embase and CINAHL was conducted to identify relevant articles.
METHODS : A systematic search was conducted on MEDLINE , Scopus and African Index Medicus.
Methods : At age 60-64 , participants from a British birth cohort study wore accelerometers for @number@ days.
METHODS : A task consisting in @number@ trials of grasping of rulers was administered to each subject and studied with a video analysis software.
METHODS : At baseline , @number@ dementia-free subjects aged 65-86 years underwent bilateral carotid ultrasonography measures of CP and plaque-free CCA-IMT.
METHODS : At baseline total of @number@ subjects with a mean age of @number@ ( ±7.82 ) were included.
METHODS : A tentacle-shaped flat mesh with a large central body and integrated arms was used to repair incisional hernia in @number@ elderly patients.
METHODS : A thematic analysis of secondary qualitative data was performed.
METHODS : A third-party payer perspective was used to determine the costs and benefits of three effective fall interventions.
METHODS : A total of @number@ adults were enrolled in this prospective nonrandomized clinical trial.
METHODS : A total of @number@ adults with photoaging skin were recruited.
METHODS : A total of @number@ asymptomatic elderly individuals with laboratory homeostasis were enrolled at baseline.
METHODS : A total of @number@ cases were divided into @number@ groups randomly , received PVRV under the Zagreb and Essen regimens respectively.
METHODS : A total of @number@ Caucasian female participants were randomly assigned to apply the test regimen or control regimen for @number@ weeks.
METHODS : A total of @number@ children aged 36-83 months attending @number@ day care centers in Prague were enrolled during February and @date@ .
METHODS : A total of @number@ children and adolescents aged 8-17 years from two districts of Shanghai was selected by using stratified random sampling method.
METHODS : A total of @number@ Chinese adults who grew up in rural Yongnian County , Handan City , Northern China , were included.
METHODS : A total of @number@ Chinese subjects with T2DM were included.
METHODS : A total of @number@ cognitively normal Alzheimer's Disease Neuroimaging Initiative participants completed a neuropsychological assessment and florbetapir PET scan.
METHODS : A total of @number@ community-dwelling adults aged older than @number@ years ( mean age @number@ years ) participated in the study.
METHODS : A total of @number@ community-dwelling adults ( @number@ men and @number@ women ) aged ≥65 years were included in the analysis.
METHODS : A total of @number@ community dwelling older adults from wave I and II were recruited through a multistage random sampling method.
METHODS : a total of @number@ community-dwelling older adults were assessed using Fried's frailty phenotype and the timed up and go ( TUG ) test.
METHODS : A total of @number@ community-dwelling older women were recruited from three cities in south-east Korea.
METHODS : A total of @number@ community dwelling , well , older adults were recruited.
METHODS : A total of @number@ consecutive patients with BD were screened and upper and lower GI endoscopies were performed in @number@ patients.
METHODS : A total of @number@ dementia-free subjects aged @number@ to 80years in @number@ were followed up through @number@ without dementia occurrence.
METHODS : A total of @number@ elderly Chinese patients with CKD were enrolled.
METHODS : A total of @number@ elderly individuals in care in Poland were included in the study.
METHODS : A total of @number@ elderly men ( 65-91 years ) living independently in Kyoto , Japan , participated in this study.
METHODS : A total of @number@ elderly patients with pathologically-confirmed advanced NSCLC with EGFR wild-type were recruited between @date@ to @date@ .
METHODS : A total of @number@ elderly people and @number@ non-elderly people were enrolled.
METHODS : A total of @number@ eligible female participants aged between @number@ and @number@ were sent an invitation pack from their GP practice.
METHODS : A total of @number@ facial halves were examined from @number@ consecutive deep-plane rhytidectomies performed over a period of @number@ months.
METHODS : A total of @number@ female participants were invited to rate how much they liked four different cosmetic creams applied to their forearms.
METHODS : A total of @number@ females were included and randomized into two groups.
METHODS : A total of @number@ fetal lung measurements were longitudinally evaluated in @number@ healthy fetuses between @number@ and @number@ weeks ' menstrual age.
METHODS : A total of @number@ French community dwellers aged @number@ years and older from PAQUID cohort study were included.
METHODS : A total of @number@ FTD patients were enrolled consecutively from multi-center memory clinics using a nationwide FTD register.
METHODS : A total of @number@ healthy children ( @number@ males , @number@ females ) aged 6-19 y were enrolled.
METHODS : A total of @number@ healthy corneas of @number@ subjects , distributed in four age categories , underwent in vivo corneal confocal microscopy.
METHODS : A total of @number@ healthy eligible men , aged 30-70 years , were recruited from Tehran Lipid and Glucose study cohort.
METHODS : A total of @number@ healthy eyes in @number@ subjects were examined at @number@ predefined times within @number@ h.
METHODS : A total of @number@ healthy men and women aged @number@ to @number@ years participated in this study.
METHODS : A total of @number@ healthy patients aged between @number@ and @number@ years were included.
METHODS : A total of @number@ healthy subjects voluntarily and @number@ years or above admitted to a teaching hospital for a physical check-up in @number@
METHODS : A total of @number@ healthy subjects were enrolled in this study.
METHODS : A total of @number@ healthy Uygur inhabitants from Hetian region , Xinjiang province were enrolled.
METHODS : A total of @number@ healthy volunteers of both genders between age group 20-65 years were selected by random method.
METHODS : A total of @number@ healthy women aged 18-65 , divided into four similar age groups , were included in this study.
METHODS : A total of @number@ HE ( @number@ males , @number@ females ) aged 57-91 years participated as subjects in the study.
METHODS : A total of @number@ hospitalized geriatric patients aged @number@ years and older were selected using convenience sampling method in a cross-sectional study.
METHODS : A total of @number@ incident cases of CRC between @number@ and @number@ from Guangzhou Cancer Registry were identified.
METHODS : A total of @number@ individuals participated in the study.
METHODS : A total of @number@ individuals with dementia living in a veterans ' home in southern Taiwan were consecutively enrolled.
METHODS : A total of @number@ individuals with type @number@ diabetes ( mean age 62±8years , HbA1c @number@.9±1.1% ) completed a neuropsychological test battery.
METHODS : A total of @number@ intervertebral discs ( IVDs ) from @number@ dogs of different breeds were used.
METHODS : A total of @number@ Japanese patients underwent the lowering the lower eyelid procedure between @number@ and @number@
METHODS : A total of @number@ Japanese postmenopausal women participated in the association study between the single nucleotide polymorphism genotype and plasma homocysteine or folate.
METHODS : A total of @number@ long-term care staff viewed and evaluated the training video.
METHODS : A total of @number@ Malaysian older adults aged ≥60 years were recruited using multistage random sampling in a population based cross-sectional study.
METHODS : A total of @number@ male SD rats were equally and randomly divided into normal control , model , EA and EA control groups.
METHODS : A total of @number@ men and women aged ≥65 years was studied in a 12-year epidemiological population-based study.
METHODS : A total of @number@ men from the Malaysian Aging Male Study were included in the analysis.
METHODS : A total of @number@ men underwent digital rectal examination of the prostate and completed an IPSS questionnaire.
METHODS : A total of @number@ men with advanced or metastatic PCa treated with ADT were studied.
METHODS : A total of @number@ middle-aged patients with moderate-to-severe OSAHS were included.
Methods A total of @number@ NAFLD patients without CKD were enrolled.
METHODS : A total of @number@ non-carious Class-V lesions in @number@ patients were restored with Clearfil AP-X ( Kuraray ) .
METHODS : A total of @number@ non-demented individuals were selected from the Gait and Alzheimer Interactions Tracking study , which is a cross-sectional study.
METHODS : A total of @number@ normal eyes ( @number@ eye per subject ) were imaged using Cirrus , RTVue , and 3D-OCT.
METHODS : A total of @number@ @number@ individuals underwent magnetic resonance imaging ( MRI ) scans.
METHODS : A total of @number@ ( @number@ men ) subjects were included in the study.
METHODS : A total of @number@ older adults aged @number@ years and older participated in this study.
METHODS : A total of @number@ older adults followed personalized , 12-week strength and balance training plans.
METHODS : A total of @number@ older community-dwelling volunteers , aged @number@.6±1.0 years old , were examined and followed for @number@ years.
METHODS : A total of @number@ older men and women were questioned prospectively , face-to-face , regarding their readiness to relocate.
METHODS : A total of @number@ old veterans with dementia living in two veterans ' homes in northern Taiwan were recruited.
METHODS : A total of @number@ outpatients ( @number@ men and @number@ women , mean age @number@.2±6.8years ) were evaluated.
METHODS : A total of @number@ outpatients with a clinical diagnosis of MCI were consecutively enrolled and entered in the study.
METHODS : A total of @number@ participants , aged 33±10years , underwent arteriography and standard 12-lead electrocardiography ( ECG ) .
METHODS : A total of @number@ participants from the Berlin Aging Study II were included.
METHODS : A total of @number@ participants of the Finnish Longitudinal Study of Municipal Employees had retired during @date@ and @date@ .
METHODS : A total of @number@ participants participated in the study ranging in age from @number@ to @number@
METHODS : A total of @number@ participants were enrolled.
METHODS : A total of @number@ participants were included in this study ( @number@ ± @number@ years ) .
METHODS : A total of @number@ patients aged > 80 years , referred with suspected peripheral arterial disease , were categorized into octogenarians and nonagenarians.
METHODS : A total of @number@ patients ( age @number@ ± @number@ years ) were enrolled.
METHODS : A total of @number@ patients of both sexes aged over @number@ were evaluated.
METHODS : A total of @number@ patients participated in this cross-sectional study.
METHODS : A total of @number@ patients undergoing arthroscopic rotator cuff repair for full-thickness tears were enrolled in a prospective study.
METHODS : A total of @number@ patients underwent curative elective CRC resection between @number@ and @number@
METHODS : A total of @number@ patients underwent FLAIR , 3D-TOF-MRA and Gd-3DBB with a @number@.5-T scanner.
METHODS : A total of @number@ patients underwent MR imaging of the inner ear at 3T.
METHODS : A total of @number@ patients were investigated in this cross-sectional study.
METHODS : A total of @number@ patients who sought facial rejuvenation treatment in Shanghai 9th People's Hospital were invited in this study.
METHODS : A total of @number@ patients who underwent hepatectomy for HCC from @number@ to @number@ at Wakayama Medical University Hospital were reviewed.
METHODS : A total of @number@ patients who underwent orchiectomy for TGCT were investigated for CD66b positive tumor-infiltrating neutrophils ( CD66b + TINs ) .
METHODS : A total of @number@ patients with cirrhosis ( age 55±7 years , male @percent@ ) were recruited.
METHODS : A total of @number@ patients with DLB and PDD were referred for a clinical examination with videofluoroscopy.
METHODS : A total of @number@ patients with end-stage liver disease ( ESLD ) were included in this prospective , cross-sectional study.
METHODS : A total of @number@ patients with essential hypertension were enrolled to receive a daily dose of @number@ mg irbesartan for @number@ days.
METHODS : A total of @number@ patients with Fitzpatrick skin types III and IV were divided into six groups.
METHODS : A total of @number@ patients with MCI and @number@ healthy older adults were recruited.
METHODS : A total of @number@ patients with SVD were recruited from memory clinics.
METHODS : A total of @number@ pediatric patients ≤ @number@ years were enrolled.
METHODS : A total of @number@ people aged 60-84 years from seven European countries answered a questionnaire ( response rate @percent@ ) .
METHODS : A total of @number@ persons older than @number@ years of age were recruited at a community health centre.
METHODS : A total of @number@ presbycusis patients and @number@ control subjects were enrolled in the study after examination by the otolaryngologist and audiology tests.
Methods : A total of @number@ PSP and @number@ healthy older adult controls participated in this study.
METHODS : A total of @number@ questionnaires were sent by mail to a representative sample of healthy pensioners.
METHODS : A total of @number@ sporadic age-related cataract patients and @number@ unrelated random healthy controls participated in our study.
METHODS : A total of @number@ stable CAD patients who underwent elective coronary intervention were enrolled in this clinical study.
METHODS : A total of @number@ subjects aged @number@ - @number@ years old were recruited from @number@ Chinese cities in @number@
METHODS : A total of @number@ subjects aged @number@ to @number@ years participated in this study.
METHODS : A total of @number@ subjects aged @number@ years or above were recruited from two urban communities in Shanghai.
METHODS : A total of @number@ subjects comprising @number@ patients with MDD and @number@ healthy controls were included in our study.
METHODS : A total of @number@ subjects drawn from a community with @number@ residents in northern Taiwan were examined.
METHODS : A total of @number@ subjects ( mean age @number@ ± @number@ years ) were studied.
METHODS : A total of @number@ subjects ( @number@ eyes ) were enrolled in this cross-section study.
METHODS : A total of @number@ subjects ( @number@ males and @number@ females ) aged 19-75 years were enrolled.
METHODS : A total of @number@ subjects ( @number@ males and @number@ females ) aged @number@.15-79 years were enrolled.
METHODS : A total of @number@ subjects were enrolled in this 24-week investigation at three sites in the United States.
METHODS : A total of @number@ subjects were included in this study.
METHODS : A total of @number@ subjects were recruited from a health check-up program.
METHODS : A total of @number@ undecalcified human temporal bones were examined.
METHODS : A total of @number@ voluntary middle-aged men who underwent screening for prostate health were recruited.
METHODS : A total of @number@ volunteers participated in the study from a range of self-declared ethnic backgrounds.
METHODS : A total of @number@ women ( 65-80 years old ) were randomized to either an experimental group or a control group.
METHODS : A total of @number@ women aged @number@ to @number@ years considering aesthetic treatments participated in an online research survey using Maximum Difference scaling.
METHODS : A total of @number@ women aged @number@ to @number@ years were enrolled in this cross-sectional study.
METHODS : A total of @number@ women who had undergone conservative surgery for borderline ovarian tumors between @date@ and @date@ were eligible.
METHODS : A total of @number@ young healthy volunteers , and @number@ older men aged @number@ years and older participated in the present study.
METHODS : A trained librarian created a search strategy that was peer reviewed for completeness.
METHODS : A trial was conducted from @date@ - @date@ in two hospitals in northern Taiwan.
METHODS : A two-part questionnaire was sent to all orthopaedic surgeons in Ontario in @number@
METHODS : A two-week international service-learning project was undertaken by visiting SA and learning about their nursing system and care of older adults.
METHODS : Auditory evoked fields were measured from seven 4-year-old children in a 64-channel KIT whole-head gradiometer MEG system.
METHODS A unique model of comanagement for elderly patients undergoing lumbar fusion surgery was implemented at a major academic medical center.
METHODS : Auricular and septal cartilage specimens were stained using Safranin O for glycosaminoglycans , Verhoeff's stain for elastin , and Masson's trichrome for collagen.
METHODS : A validated questionnaire was used to collect data from patients at @number@ HPC institutions in Berlin over @number@ months.
METHODS : Average heights and associated secular trends were analyzed for each state and in relation to socioeconomic variables.
METHODS : A walking version of the Trail Making Test ( Walking Executive Function Task , [ WEFT ] ) was used.
METHODS : A web based search utilising five search terms was employed.
METHODS : A weighted GRS was created using @number@ single nucleotide polymorphisms associated with LDL-C levels.
METHOD : SB and DB were determined in @number@ older women.
METHODS : Based on a cross-sectional design , @number@ community-dwelling volunteers aged @number@ and older were recruited.
METHODS : Based on findings from a focus group questionnaires were developed and pretested.
METHODS : Based on the sample of China Health and Retirement Longitudinal Survey database in @number@ a structural equation modeling is established.
METHODS : Baseline and follow-up cross-sectional surveys were conducted before and after a nutrition intervention program in @number@ national poverty counties in China.
METHODS : Baseline and follow-up data on @number@ participants of the Swedish National Study on Aging and Care - Blekinge was used.
METHODS : Baseline data from @number@ patients from the DREAM registry were used for analyses.
METHODS : Baseline data of @number@ women aged 70-80 years recruited to a randomised falls prevention trial ( DEX ) ( NCT00986466 ) were used.
METHODS : baseline data of the prospective BELFRAIL study ( BFC80 + ) were analysed.
METHODS : Baseline data were analyzed from @number@ adults , aged 70-79 , participating in the Health , Aging , and Body Composition Study.
METHODS : Baseline data were obtained from a well-characterized prospective cohort study of @number@ depressed and @number@ non-depressed older persons ( ≥60years ) .
METHODS : Baseline echocardiography and a composite endpoint ( cardiovascular mortality and hospitalization ) were evaluated in @number@ T2DM patients from @number@ prospective cohorts.
METHODS : Baseline health and periodontal examinations were carried out in @date@ .
METHODS : Baseline studies were random Swedish samples aged 46-75 years ( mean @number@ ) ( n = 1643 ) interviewed in @number@ or @number@
METHODS : Basic characteristics , clinical and radiological course , and 30-day outcomes of these patients were recorded.
METHODS : Before the meeting , panel participants were asked to review @number@ articles and to complete @number@ questionnaires.
METHODS : Behavioral and neurological data were collected from subjects in an observational study.
METHODS : Behavioural data were assessed using a checklist of weight loss obstacles.
METHODS : Best-corrected visual acuity ( BCVA ) measured by a modified Early Treatment Diabetic Retinopathy Study protocol.
METHODS : Between @date@ and @date@ , @number@ cases of AAA were treated with EVAR.
METHODS : Between @date@ and @date@ , @number@ elderly oncological patients underwent right IJV CVP placement under ultrasound-guidance.
METHODS : Between @date@ and @date@ , @number@ OP and @number@ YP underwent LRYGB.
METHODS : Between @date@ and @date@ , @number@ patients were treated with HA to correct tear trough deformities.
METHODS : Between @date@ and @date@ , the World Health Organization conducted a nationwide study on AGEing ( SAGE ) and Adult Health in Ghana.
METHODS : Between @date@ and @date@ , we did a prospective and multicenter study including patients ≥ @number@ years old referred for TAVI.
METHODS : Between January and @date@ , @number@ patients with RA were enrolled in this observational cross-sectional study.
METHODS : Between @number@ and @number@ data of patients > 85 years old who required an elective AAA repair at our institution were collected prospectively.
METHODS : Between @number@ and @number@ @number@ participants from the Rotterdam Study underwent cerebral vasomotor reactivity measurements using transcranial Doppler.
METHODS : Between @number@ and @number@ @number@ patients with PA were treated.
METHODS : Between @number@ and @number@ we assessed alcohol consumption annually using the alcohol use disorders identification test-consumption ( AUDIT-C ) .
METHODS : Between @number@ and @number@ we performed I-123 BMIPP scintigraphy for patients with esophageal cancer before and six months after curative mediastinal RT.
METHODS : Bilateral scans of multiple mimic and masticatory muscles were performed at rest and during contraction in @number@ volunteers , aged 21-93 years.
METHODS : Blood [ HA ] were quantified by high performance liquid chromatography.
METHODS : Blood samples of patients scheduled for a screening colonoscopy were collected before the procedure.
METHODS : Blood samples were collected before and after each dive.
METHODS : Blood samples were collected from @number@ subjects with AD , @number@ with MCI , @number@ OCN , and @number@ YCN.
METHODS : Blood samples were obtained from @number@ healthy and @number@ HIV-1-infected individuals : @number@ receiving antiretroviral therapy and @number@ naive to treatment.
METHODS : Blood specimens were collected from elderly residents by standard procedures.
METHODS : BMI was assessed at ages @number@ @number@ @number@ and @number@ years in @number@ male veterans from the Vietnam Era Twin Study of Aging.
METHODS : Body composition was measured bi-annually by bioelectrical impedance in @number@ children from a birth cohort.
METHODS : Body mass parameters were assessed using bioelectrical impedance analysis.
METHODS : Bonded dentin specimens were prepared using three different types of adhesive systems.
METHODS : Bonded interface specimens were prepared using a two-step ( SB ) or three-step ( SBMP ) etch-and-rinse adhesive.
METHODS : Both eyes of each volunteer were scanned by an RTVue XR Avanti ; Optovue with OCTA using the split-spectrum amplitude-decorrelation angiography algorithm technique.
METHODS : BP was measured among @number@ @number@ adults from a general population.
METHODS : Brain volumes were obtained using automatic tissue segmentation of magnetic resonance imaging scans.
Methods by which older people themselves and nursing staff can help to promote and improve skin health are identified.
METHODS : Calcification of VSMCs was induced in vitro using β-glycerophosphate ( β-GP ) .
METHODS : Calcifying VSMCs ( CVSMCs ) were isolated from cultured human arterial smooth muscle cells through limiting dilution and cloning.
METHODS : Canada's Population Health Promotion Model was chosen as a comprehensive tool to understand and prevent social isolation.
METHODS : Cancer patients aged ≥70 years scheduled to receive the first cycle of a new chemotherapy regimen were enrolled.
METHODS : Cardiovascular risk factors from participants of Beijing epidemiological investigation were analyzed.
METHODS : carotid intima media thickness ( IMT ) was assessed using ultrasonography and pulse wave velocity ( PWV ) was determined with applanation tonometry.
METHODS : Case-control study of @number@ HIV-infected individuals without retinal OIs and @number@ gender / age-matched HIV-seronegative individuals.
METHODS : Case records of @number@ patients with dementia ( @number@ of them bilingual ) diagnosed in a specialist clinic were reviewed.
METHODS : Case report.
METHODS : Cases of oxazepam or nordiazepam overdoses collected at the Paris poison control centre from @number@ to @number@ on the basis of self-report.
METHODS : Cases were identified by hospital medical record review , General Practitioners and the local MS Society.
METHODS : CD34 RESULTS : Induced endothelial cells expressed specific endothelial cell surface markers and also exhibited the capacity for cell proliferation and neovascularization.
METHODS : Cell growth rate was analyzed , and through western blotting , mitogenic signaling was observed.
METHODS : Cell lysates of human TM cells , RAW @number@ macrophages , and PC12 cells were subjected to western blot analysis.
METHODS : Cells were exposed to glucose and pyruvate.
METHODS : Cerebellar cortex was snap frozen and stored at -80°C in aliquots for biochemical analyses.
METHODS : Cerebellar PC counts were performed in seven ET , six PD and two normal control brains.
METHOD : Schizophrenic patients ( N = @number@ ) and a comparison group ( N = @number@ ) were recruited as subjects.
METHODS : Cholesterol trajectories from midlife through late life were modeled using generalized additive mixed models and mixed-effects regression models.
METHODS : Chronic hepatitis C patients receiving pan-oral DAA therapy from @date@ to @date@ were evaluated.
METHODS : CINAHL , Cochrane , EMBASE and MEDLINE were searched up to @date@ .
METHODS : Clearance values for three coagulation factors ( rVIIa , rVIII and rIX ) for adults and children were obtained from the literature.
METHODS : Clinical cases ( n = @number@ ) of LDH were retrospectively analyzed.
METHODS : Clinical , cognitive and 3-Tesla brain MRI assessments were performed among participants of three studies from Singapore , Hong Kong and Korea.
METHODS : Clinical , cognitive , and neuropathological phenotypes were collected in @number@ prospective cohorts on aging ( n = @number@ subjects ) .
METHODS : clinical correlates of sensory neuropathy were assessed in HIV-positive and HIV-negative participants.
METHODS : Clinical data and blood were collected from Children and women : AntiRetrovirals and the Mechanism of Aging ( CARMA ) cohort study participants.
METHODS : Clinical data of all peptic ulcer subjects detected via endoscopy at four participating hospitals were prospectively collected between @date@ and @date@ .
METHODS : Clinical , demographic and ECT data from @number@ patients in ECT research studies were examined.
METHODS : Clinical outcome assessment was based on the absolute and relative Constant scores and the active range of motion.
METHODS : Clinical periodontal attachment loss was calculated to determine the progress of periodontitis.
METHODS : Clinical screening for dementia was carried out at an Alzheimer disease center.
METHODS : Cluster sampling of populations age > @number@ was used.
METHODS : Cognitively normal , aMCI and AD Cantonese-speaking Chinese older adults were recruited from a memory clinic and the community.
METHODS : Cognitive performance was assessed in @number@ visually normal , community-dwelling older adults ( mean = @number@ ± @number@ years ) .
METHODS : Cohort study design with repeat surveys ( @number@ @number@ and @number@ ) .
METHODS : COHORT : Veterans Aging COHORT Study Virtual COHORT ( VACS VC ) .
METHODS : COL2A1 gene polymorphism was investigated in DLS subjects compared to healthy controls to investigate the possibility of its association with COL2A1 gene.
METHODS : Community-based cross-sectional study involving @number@ subjects aged ≥ @number@ years from Chandigarh , India.
METHODS : Community-dwelling , 75- to 90-year-old people ( n = @number@ ) were interviewed face-to-face using standard questionnaires.
METHODS : Community-dwelling older adults ( n = 41 , mean age = 75 ) completed mobility and gait tasks.
METHODS : Community-dwelling older adults were recruited from senior centers across Pennsylvania.
METHODS : Community-dwelling subjects ( n @number@ @number@ males and @number@ females ; aged 64-93 years ) were analysed.
METHODS : Community Health Survey data obtained by the Korea Centers for Disease Control and Prevention in @number@ was used for this study.
METHODS : Community outreach workers completed the intervention and assessment , enrolling veterans from @number@ counties in a southern state.
METHODS : Community pharmacists used a clinical decision support system ( CDSS ) for seven antibiotics.
METHODS : Comparative gene expression profiling of both substances in the EpiDerm FT full thickness skin substitute model was undertaken.
METHODS : Comprehensive ophthalmic examinations were performed at a school visit.
METHODS : Computed tomography neck scans of @number@ patients aged @number@ to @number@ years were studied.
METHODS : Computer-assisted instruction was developed and tested systematically in four phases during @number@ and these are outlined.
METHODS : Conditioned medium ( CM ) was collected from adult and fetal donor eyes and analyzed for trophic factor composition by multiplex ELISA.
METHODS : Confirmed cases of spontaneous septic arthritis in the over-65 population were studied.
METHODS : Confluent monolayers of human fetal RPE ( hfRPE ) cells were cultured using an in vitro model mimicking extracellular AGE accumulation.
METHODS : Confocal laser scanning microscopy was used for 3D measurement of the surface morphology of silicon replicas taken from the cheek.
METHODS : Consecutive CAD patients , aged ≥60 years , who underwent non-cardiac surgery at five medical centers in China , were prospectively enrolled.
METHODS : Consecutive computed tomography ( CT ) imaging studies performed at a university-affiliated hospital were selected for review.
METHODS : Consecutive HCV + patients were recruited from centers in China and the USA.
METHODS : Consecutive patients of the Ohio State University Comprehensive Wound Center ( CWC ) were surveyed with the Berlin and Epworth questionnaires.
METHODS : Consecutive patients , referring for a CV assessment in a @number@ months period , were screened.
METHODS : Consecutive patients with ICH were enrolled as part of the Multicenter Study on Cerebral Hemorrhage in Italy ( MUCH-Italy ) .
METHODS : Consecutive patients with physician diagnosed COPD exacerbations admitted to a public hospital during a 1-year period were studied prospectively.
METHODS : Consecutive sampling was performed over three semesters from @date@ to @date@ .
Methods : Consecutive septic patients with positive blood culture admitted to @number@ Italian MWs were included.
METHODS : Consecutive subjects receiving percutaneous mesenteric interventions for acute and chronic mesenteric ischemia from @number@ to @number@ were identified retrospectively.
METHODS : Consensus discussion over the past @number@ months leading to summarized views of seven experts from six countries.
METHODS : Controlled lighting images of skin were taken with the Visia CR.
METHODS : Coplanar zirconia specimens were bonded to CoCr-cylinders measuring @number@ mm in diameter and @number@ mm in height.
METHODS : Core-needle biopsies of the renal cortex were obtained at the time of living kidney transplantation at three centers between @number@ and @number@
METHODS : Corneas from donors @number@ to @number@ years of age were assigned by @number@ eye banks to participants without respect to recipient factors.
METHODS : Corneas from donors @number@ to @number@ years old were assigned to participants using a randomized approach , without respect to recipient factors.
METHODS : Coronal computerized tomography scans of @number@ heads of patients who had no head injury , skull fracture , or craniofacial abnormalities were reviewed.
METHODS : Cortisol and 5-HIAA acid levels were measured by commercial enzyme-linked immunosorbent assay kits.
METHODS : Cortisol levels were measured using morning saliva samples from @number@ individuals with aMCI and from @number@ healthy elderly.
METHODS : Costs were estimated with an epidemiological model using California SHS home exposure rates and published relative risks.
METHODS : Cox proportional hazard models were used to investigate the association between intra-individual hormone changes and all-cause , CVD and cancer mortalities.
METHODS : Cox proportional hazards regression was initially used to determine the direct association between education achievement and incident T2DM.
METHODS : CRELES contains baseline interviews in @number@ ( n = 2827 ) with follow-up interviews in @number@ and @number@
METHODS : Cross-sectional analyses of baseline data from the SCAMOB study ( ISRCTN @number@ ) involving @number@ community-living ambulatory adults aged 75-81 years.
METHODS : Cross-sectional analyses of baseline data of the ' Life-Space Mobility in Old Age ' cohort study were carried out.
METHODS : Cross-sectional analyses of the \ "Life-space mobility in old age \ " cohort including @number@ community-dwelling 75-90-year-old of central Finland.
METHODS : Cross-sectional analyses of the National Health and Nutrition Examination Survey from @number@ to @number@
METHODS : Cross-sectional analyses were conducted in @number@ non-institutionalized older adults ( @number@ males ) .
METHODS : Cross-sectional analysis of a randomly-selected group of @number@ community-dwelling men in the MrOS cohort recruited between @number@ and @number@
METHODS : Cross-sectional analysis of baseline data from the Women's Health Initiative , including @number@ women aged @number@ years or older.
METHODS : Cross-sectional analysis of elderly individuals recruited from outpatient clinics ( n = 298 ) and nursing homes ( n = 276 ) .
Methods : Cross-sectional analysis of @number@ participants enrolled in a multicenter observational study of older adults admitted to @number@ acute hospital wards in Italy.
Methods : Cross-sectional analysis of @number@ participants from The Irish Longitudinal Study on Ageing , a national cohort of community-dwelling adults aged ≥50 years.
METHODS : Cross-sectional analysis of @number@ participants ( @percent@ aged @number@ years and older ) enrolled in the InCHIANTI study.
METHODS : Cross-sectional analysis of wave @number@ data from the Irish longitudinal study on ageing ( TILDA ) was performed.
METHODS : Cross-sectional analysis was carried out on @number@ elderly subjects , @number@ of whom were also included in a 2-year longitudinal follow-up study.
METHODS : Cross-sectional clinical and US investigation of both knee joints during the @number@ follow-up of the prospective population-based Bruneck Study.
METHODS : Cross-sectional cohort of @number@ maintenance hemodialysis patients in the Marrakech area.
METHODS : Cross-sectional , community-based data from the World Health Survey on @number@ individuals aged ≥ @number@ years were analyzed.
METHODS : Cross-sectional , comparative study of elderly patients managed in ear , nose and throat clinics.
METHODS : Cross-sectional , consecutive case study conducted at the university hospital of University of Tokyo Graduate School of Medicine.
METHODS : Cross-sectional data from @number@ @number@ community-dwelling older adults ( mean age @number@ years ; @number@ women ) were analyzed.
METHODS : Cross-sectional data from the @number@ and Up Study were used.
METHODS : Cross-sectional data from three studies were used.
METHODS : Cross sectional data was derived from the Osteoarthritis Initiative.
METHODS : Cross-sectional data were collected from the COURAGE study.
METHODS : Cross-sectional data were from the 2008-2010 Survey of the Health of Wisconsin , a representative sample of adults aged 21-74 years.
METHODS : Cross-sectional data were from the population-based National Health and Nutrition Examination Survey ( 1999-2002 ) .
METHODS : Cross-sectional descriptive study of @number@ ED patients in the city of Fano ( Italy ) .
METHODS : Cross-sectional , follow-up ( @number@ years ) , and case-control analyses were undertaken in @number@ independent populations.
METHODS : Cross-sectional prospective study , carried out with @number@ randomly selected subjects ( @number@ women and @number@ men ) .
METHODS : Cross sectional study.
METHODS : Cross-sectional study , in @number@ health centres in Madrid.
METHODS : Cross-sectional study in @number@ individuals ( @number@ with COPD , @number@ smokers without COPD , and @number@ nonsmokers without COPD ) .
METHODS : Cross-sectional study involving @number@ patients on dialysis for > 12 months.
METHODS : Cross-sectional study of 45- to 65-year-old HIV-infected subjects on antiretroviral therapy > 6 months with undetectable HIV-1 viral load.
METHODS : Cross-sectional study of a community-dwelling cohort of @number@ men aged @number@ years or older recruited from six U.S. centers.
METHODS : Cross-sectional study of a community sample of @number@ African-American men aged between @number@ and @number@ years.
METHODS : cross-sectional study of adults ≥ @number@ years.
METHODS : Cross-sectional study of elderly individuals with vestibular disorders.
METHODS : Cross-sectional study of HS and a matched comparison group recruited from the general population was carried out.
METHODS : Cross-sectional study of @number@ community-dwelling men aged @number@ years or over with no history of terminal illnesses or neurodegenerative diseases.
METHODS : Cross-sectional study of @number@ men aged 71-92 years recruited from primary care practices who were part of an on-going population-based cohort.
METHODS : Cross-sectional study of @number@ men and @number@ women aged 70-77.
METHODS : Cross-sectional study of women between @number@ to @number@ years old living in Parnamirim.
METHODS : Cross-sectional study using the Iowa Corrections Offender Network which contains health records of all inmates in Iowa.
METHODS : Cross-sectional study with @number@ elderly ( @number@ years old or more ) of coexistence groups ( for physical or recreational activities ) .
METHODS : CT images of both ears of @number@ human subjects were studied.
METHODS : CT was evaluated in @number@ STGD patients and in @number@ controls.
METHODS : Cultured ARPE-19 cells were treated with H₂O₂ at different concentrations and cell viability was measured with the MTT assay.
METHODS : Cumulative fibre exposure and production years were categorised into exposure levels at five manufacturing locations.
METHODS : Cytokine array was performed to identify Jak2V617F-related cytokine expression and secretion.
METHODS : Daily intake of food groups and dietary nutrients at baseline was assessed by a food frequency questionnaire.
METHODS : Data analyses were performed using a sample of @number@ participants from the @number@ to @number@ National Health and Nutrition Examination Surveys.
Methods : Data analysis was based on the Population Study of Chinese Elderly in Chicago ( PINE ) .
METHODS : Data are drawn from the Washington Heights-Inwood Columbia Aging Project ( WHICAP ) .
METHODS : Data are from a substudy of the Nurses ' Health Study II ( N = @number@ ) .
METHODS : Data are from a UK birth cohort of @number@ participants with a clinical assessment for kOA at age @number@
METHODS : Data are from @number@ community-dwelling older persons attending a geriatric cardiovascular clinic.
METHODS : Data are from @number@ individuals ( @number@ men and @number@ women ) aged @number@ years and older.
METHODS : Data are from @number@ older persons aged ≥80 years enrolled in the ilSIRENTE study.
METHODS : Data are from the Age , Gene / Environment Susceptibility-Reykjavik Study , a prospective cohort aged 66-96 y at baseline.
METHODS : Data are from the Health and Retirement Study , a longitudinal survey of community-dwelling U.S. adults.
Methods : Data are from the National Health and Nutrition Examination Survey ( 1999-2000 , 2001-2002 ) on @number@ adults aged @number@ years or older.
METHODS : Data came from @number@ autopsied participants without FTLD in @number@ community-based studies of aging.
METHODS : Data came from older adults in the Rush Memory and Aging Project , an ongoing longitudinal cohort study of aging.
METHODS : Data came from the 2004-2011 waves of the Drug Abuse Warning Network ( DAWN ) .
METHODS : Data came from the Advanced Cognitive Training for Independent and Vital Elderly ( ACTIVE ) Study ( N = @number@ ) .
METHODS : Data came from the English Longitudinal Study of Ageing and the national mortality registry.
METHODS : Data came from the longitudinal Swedish Adoption / Twin Study of Aging ( SATSA ) .
METHODS : Data came from the public use files of the @number@ to @number@ National Survey on Drug Use and Health.
METHODS : Data collected from control groups of two clinical trials conducted during 2001-2004 and during 2005-2009 were selected.
METHODS : Data collection took place in three residential aged care homes in Vienna , Austria.
METHODS : Data come from a four-wave study from @number@ to @number@ among Dutch workers ( n = 1 , 424 ) .
METHODS : Data come from our @number@ survey of @number@ PSWs.
METHODS : Data come from the Montreal Neighbourhood Networks and Healthy Aging Study ( n = 2707 ) .
METHODS : Data come from the @number@ American Time Use Survey.
METHODS : Data come from the Social Environment and Biomarkers of Aging Study and its parent study , the Taiwan Longitudinal Study of Aging.
METHODS : Data comes from the Mexican Health and Aging Study ( MHAS ) and the U.S. Health and Retirement Study ( HRS ) .
METHODS : Data for @number@ adult HPVG patients who visited our ED between @date@ and @date@ were analyzed.
METHODS : Data for @number@ adult HPVG patients who visited the EDs of @number@ research hospitals between @date@ and @date@ were analyzed.
METHODS : Data for the present research were derived from the Belgian Aging Studies ( N = @number@ ) .
METHODS : Data from adult patients with HPVG who visited our ED between @date@ and @date@ were analyzed.
METHODS : Data from a national survey of Singaporeans @number@ years and over was used.
METHODS : Data from a population-based 8-year follow-up of a large cohort study conducted in the Saarland , Germany was used.
METHODS : data from a prospective sample of CI and healthy older drivers were collected.
METHODS : Data from Brazilian Health National Public System ( SUS ) were retrospectively collected with regard to PC from @date@ to @date@ .
METHODS : Data from interviews of @number@ men aged @number@ years and over were collected.
METHODS : Data from @number@ individuals aged 70-87 years from the Rugao Longevity and Ageing Study were used.
METHODS : Data from @number@ individuals aged @number@ years and older who participated in SAGE Wave @number@ ( 2009-2010 ) were analyzed.
METHODS : Data from @number@ @number@ prostate cancer patients were collected from the Longitudinal Health Insurance Database of Taiwan.
METHODS : Data from @number@ octogenarians and centenarians who participated in Phase III of the Georgia Centenarian Study were used.
METHODS : Data from @number@ older community dwelling individuals ( age ≥ @number@ years ; females : @percent@ ) enrolled the InChianti study were analysed.
METHODS : Data from @number@ participants ( age 73-92 yr ) of the AGESII-Reykjavik Study were used.
METHODS : Data from @number@ participants free of sleep medication were included.
METHODS : Data from @number@ participants ( mean age = @number@ SD = @number@ ) in @number@ with @number@ years of follow-up were studied.
METHODS : Data from @number@ Spanish speakers with normal cognition were summarized , with descriptive tables of performance on individual cognitive tests.
Methods : Data from repeated surveys of the Finnish Public Sector study , linked to records of retirement , were used.
METHODS : Data from the 2010-2012 Korea National Health and Nutrition Examination Survey V was used.
METHODS : Data from the B-PROOF ( B-vitamins for the prevention of osteoporotic fractures ) study were used , concerning community-dwelling elderly aged ≥65 years.
METHODS : Data from the controlled clinical trials are presented and reviewed for potential opportunities for further research into the treatment of cataracts and AMD.
METHODS : Data from the Global Longitudinal Study of Osteoporosis in Women ( GLOW ) 3-year Hamilton cohort were used for this study.
METHODS : Data from the Health and Retirement Study ( HRS ) were analyzed.
METHODS : Data from the Korean Longitudinal Study of Ageing ( KLoSA ) from @number@ to @number@ were analyzed.
METHODS : Data from the Korean Longitudinal Study of Aging ( KLoSA ) from @number@ and @number@ was assessed using longitudinal data analysis.
METHODS : Data from the National Comorbidity Survey , baseline and 10-year follow-up , were utilized.
METHODS : Data from the @number@ National Health and Aging Trends Study ( NHATS ) were used to identify @number@ self-reported stroke survivors aged≥65 years.
METHODS : Data from the pertinent literature were examined to inform our conclusions.
METHODS : Data from the population-based Study of Health in Pomerania , Germany , were used.
METHODS : Data from the Primary Care Research in Substance Abuse and Mental Health for the Elderly ( PRISM-E ) study were utilized.
METHODS : Data from the prospective CRIteria to assess appropriate Medication use among Elderly complex patients ( CRIME ) cohort were used.
METHODS : Data from the Swedish Aging with Spinal Cord Injury Study ( SASCIS ) .
METHODS : Data from this cross-sectional study was collected from the COURAGE study.
METHODS : Data from three studies evaluating CGM in older adults ( ≥70 years of age ) , with stable glycaemic control were analyzed retrospectively.
METHODS : Data from three waves ( @number@ @number@ and @number@ ) of the Chinese Longitudinal Healthy Longevity Survey ( CLHLS ) were analyzed.
METHODS : Data from two longitudinal studies are analysed.
METHODS : Data from two randomized , double-blind , placebo-controlled studies were included.
METHODS : Data from waves @number@ and @number@ of the English Longitudinal Survey of Ageing provided @number@ years of follow up.
METHODS : Data ( N = @number@ ) from the Second Longitudinal Study of Aging was used.
METHODS : Data of hip fractures collected over a period of five years was analysed.
METHODS : Data of @number@ younger ( @time@ ±2.06yr ) and @number@ older women ( @number@.33±3.14yr ) were considered for this study.
METHODS : Data of the I-Lan Longitudinal Aging Study ( ILAS ) were retrieved for this study.
METHODS : Data of the Longitudinal Aging Study Amsterdam ( LASA ) , an ongoing cohort study , were used.
METHODS : Data of the Social Environment and Biomarkers of Aging Study , a population-based cohort study in Taiwan , were retrieved for the study.
METHODS : Data of TNBC patients diagnosed between @number@ and @number@ were retrospectively analyzed by computer based chart information.
METHODS : Data on farm-related incidents were sourced from the National Coroners Information System ( NCIS ) for the study period and coded.
METHODS : Data on mortality and population were collected from the World Health Organization mortality database and from the United Nations Population Prospects database.
METHODS : Data on mortality were collected from the WHO mortality database and population data were obtained from the United Nations.
METHODS : Data on @number@ elderly were obtained from the Survey on Aging , Health and Well-being ( SABE ) , @number@
METHODS : Data on @number@ subjects aged over @number@ years were finally analyzed using competing risk models.
METHODS : Data on persons aged @number@ and older ( n = @number@ ) drawn from a population-based study , Health @number@ were analyzed.
METHODS : Data on sleep apnea , primary snoring and LTL , were available for @number@ participants from the Helsinki Birth Cohort Study.
METHODS : Data on TOF patients were retrieved from database records from @number@ to @number@
METHODS : Data originated from the Longitudinal Aging Study Amsterdam ( N = 2046 , aged 57-98 years ) .
METHODS : Data originate from the Swedish National study on Aging and Care-Kungsholmen.
METHODS : Data presented in this review were collected from both research and review articles concerning ophthalmology and pharmacology.
METHODS : Data regarding demography , nutrition and functional and cognitive ability were collected through questionnaires , medical examinations and structured interviews.
METHODS : Data regarding demography , sleep , comorbidity and HRQoL were collected through questionnaires and interviews among @number@ people in Sweden.
METHODS : DATA SOURCES : PubMed ( Medline ) , clinical evidence , Embase , Cochrane reviews , and articles from reference lists.
METHODS : Data used in this study derived from the Cooperative Health Research in the Region of Augsburg ( KORA ) -Age Study.
METHODS : Data was from the Canadian Community Health Survey : Healthy Aging ( CCHS-HA ) ( n = @number@ ) conducted in 2008-2009.
METHODS : Data was from the Chinese Floating Population Chronic Disease Surveillance ( @number@ ) .
METHODS : Data was obtained from the WHO's Study on global AGEing and adult health ( SAGE ) Wave-1 ( 2007 / 10 ) .
METHODS : Data was used from the 2001-2003 National Survey of American Life ( NSAL ) .
METHODS : Data were available for @number@ males participating in the Kuopio Ischaemic Heart Disease Risk Factor Study ( Finland ) .
METHODS : Data were collected as part of the Maastricht Aging Study ( MAAS ) , a prospective study into the determinants of cognitive aging.
METHODS : Data were collected as part of the National Institute for Longevity Sciences Longitudinal Study of Aging.
METHODS : Data were collected during two 24-h periods among @number@ prostate patients undergoing androgen deprivation therapy ( ADT ) .
METHODS : Data were collected from community-dwelling Japanese adults aged 40-84 years who participated in the Longitudinal Study of Aging biennially between @number@ and @number@
METHODS : Data were collected from @number@ to @number@ from @number@ highly active antiretroviral therapy-experienced HIV infected and @number@ uninfected women.
METHODS : Data were collected from postal surveys of adults aged @number@ years and over.
METHODS : Data were collected from qualitative interviews with older people , community leaders and professionals in Christchurch and Auckland.
METHODS : Data were collected from the Taiwan Longitudinal Study in Aging in @number@ and the participant survival status was followed until @date@ .
METHODS : Data were collected in a cross-sectional side study of the Longitudinal Aging Study Amsterdam ( LASA ) .
METHODS : Data were collected on @number@ members of the Framingham Study cohort who completed foot examinations in 2002-2008.
METHODS : Data were collected through interviews with residents and participant observations ; qualitative content analysis was performed.
METHODS : Data were collected through literature review and correspondence with service providers.
METHODS : Data were collected using a structured questionnaire.
METHODS : Data were collected using the interRAI HC-Assessment in IBenC-project.
METHODS : Data were collected within the Lothian Birth Cohort @number@ and @number@ studies.
METHODS : Data were combined from several publicly available sources.
METHODS : Data were derived from a cross-sectional , correlational study of cardiovascular risk factors , cognitive function , and neuroimaging.
METHODS : Data were derived from a cross-sectional study in a southern city in Brazil.
METHODS : Data were derived from all available survey waves of the International Tobacco Control ( ITC ) Europe Surveys ( 2003-2013 ) .
METHODS : Data were derived from the Canadian Community Health Survey- Healthy Aging.
METHODS : Data were derived from the National Institute for Longevity Sciences-Longitudinal Study of Aging.
METHODS : Data were derived from the Native Elder Care Study , a cross-sectional study of @number@ community-dwelling American Indians aged ≥55 years.
Methods : Data were derived from the PINE study , a population-based study of Chinese elders in Chicago ( N = @number@ ) .
Methods : Data were derived from the Population Study of Chinese Elderly ( PINE ) at two time points : 2011-2013 and 2013-2015.
METHODS : Data were derived from the second measurement ( @number@ ) of the Living Arrangements for people with Dementia study.
METHODS : Data were drawn from a sample of the Survey of Health , Ageing and Retirement in Europe.
METHODS : Data were drawn from repeated waves of cohort studies in England , Finland , France and Sweden.
METHODS : Data were drawn from the 1996-2007 Taiwan Longitudinal Study on Aging.
METHODS : Data were drawn from the experiences of two cohorts of students who completed the programme in 2010 / 2011.
Methods : Data were drawn from the Population-Based Study of Chinese Elderly ( N = @number@ ) .
Methods : Data were drawn from the Population Study of Chinese Elderly in Chicago.
METHODS : Data were drawn from Wave @number@ ( @date@ ) of the South African Study on Global Ageing and Adult Health.
METHODS : Data were extracted from the French Hospital National Database.
METHODS : Data were extracted from the population-based cross-sectional Nord-Trøndelag Health Study ( HUNT3 2006-2008 ) .
METHODS : Data were extracted from the Surveillance , Epidemiology , and End Results database in the US and @number@ cancer registries in Germany.
METHODS : Data were extracted from the Surveillance , Epidemiology , and End Results database in the US and @number@ cancer registries in Germany.
METHODS : Data were from a national online survey of @number@ adult Australian parkrunners.
METHODS : Data were from a population-based longitudinal study , the Taiwan Longitudinal Study of Aging , with a nationally representative sample.
METHODS : Data were from four Swedish longitudinal cohort studies with a total of nearly @number@ participants and 8-25 years of follow-up.
METHODS : Data were from @number@ men and @number@ women , aged 66-96 years in the AGES-Reykjavik Study.
METHODS : Data were from @number@ men and women , aged 70-79 years , participating in the Health , Aging , and Body Composition study.
METHODS : Data were from @number@ non-cognitively impaired adults aged ≥ @number@ years in the English Longitudinal Study of Ageing.
METHODS : Data were from @number@ participants ( @percent@ men ) aged @number@.8±4.7 years from the AGES-Reykjavik Study.
METHODS : Data were from subjects of the Project of Longevity and Ageing in Dujiangyan , China.
METHODS : Data were from the Health and Retirement Study ( HRS ) , a US national sample.
METHODS : Data were from the Korean Longitudinal Study of Aging ( KLoSA ) , 2006-2012.
METHODS : Data were from the Nordic Research on Ageing Study from research sites in Denmark , Sweden , and Finland.
METHODS : Data were from the Taiwan Longitudinal Study on Aging ( TLSA ) Survey in 1996-2007 ( n = 3186 ) .
METHODS : Data were gathered using a mailed questionnaire comprising the MBI-HSS and demographic information.
METHODS : Data were obtained from a cross-sectional study.
METHODS : Data were obtained from a five-wave panel composed of older Taiwanese adults from @number@ to @number@ ( N = @number@ ) .
METHODS : Data were obtained from an education program for enhancing CPAP adherence.
METHODS : Data were obtained from a @number@ Takamatsu City health survey mailed to @number@ randomly selected Japanese individuals in Takamatsu , a medium-sized city.
METHODS : Data were obtained from Brazil , a middle income country.
METHODS : Data were obtained from the Medical Expenditure Panel Survey ( years 2004-2011 ) .
METHODS : Data were obtained from the National Health and Nutrition Examination Survey 1999-2002 databases.
METHODS : Data were obtained from the Rotterdam Study , including subjects of @number@ years and over.
METHODS : Data were obtained from the Taiwan Longitudinal Study of Aging and analyzed retrospectively.
METHODS : Data were obtained from two cross-sectional surveys in two districts in Indonesia in @number@
METHODS : Data were obtained from World Bank , WHO , and UN database for @number@ Europe countries.
METHODS : data were sourced from the Australian Department of Veterans ' Affairs Health Claims database.
METHODS : Data were taken from a prospectively follow-up study of @number@ people representative of the Spanish population aged ≥60 years.
METHODS : Data were taken from the @number@ participants in the African American Health cohort.
METHODS : Data were taken from the Toledo Study for Healthy Aging , a population-based , community-dwelling study conducted on @number@ individuals over @number@
METHODS : Data were used from people aged 60-67 years who responded to a mail survey in Brisbane , Australia , in @number@
METHODS : Data were used from the Longitudinal Aging Study Amsterdam , a random population-based cohort study ( 55-85 years ) in the Netherlands.
METHODS : DC was evaluated with FTIR-ATR and shrinkage-strain with the bonded-disk method.
METHODS : Demographic and MRI data of @number@ patients from a prospective cohort study were analyzed.
METHODS : demographic characteristics were registered.
METHODS : Demographic , clinical , and symptom data from one Australian and two U.S. studies were combined.
METHODS : Demographic , clinical , depression and apathy data were recorded for PD patients prospectively recruited from an outpatient university movement disorders clinic.
METHODS : Demographic information and postoperative complications ( @number@ days ) were evaluated.
METHODS : Depressive symptoms ( SCL-90 depression subscale ) were assessed in @number@ community-dwelling individuals age @number@ years and older.
METHODS : Depressive symptoms were assessed using the Center for Epidemiologic Studies-Depression Scale ( CES-D ) at baseline and 2- , 3- and 4-year follow-up.
METHODS : Dermascore + RESULTS : Although the size and density of FSP are not affected by aging , their shape becomes elongated.
Methods : Descriptive analyses of the National Health and Aging Trends Study ( NHATS ) , @number@
METHODS : descriptive and cross-sectional study including @number@ patients @number@ ± @number@ years old.
METHODS : Descriptive observational cross-sectional study carried out in six Portuguese nursing homes , selected by convenience , in November- @date@ .
METHODS : Descriptive retrospective study.
Methods : descriptive statistics are shown.
METHODS : Design.
METHODS / DESIGN : A randomised controlled trial ( RCT ) design will be used in the pilot study.
METHODS / DESIGN : A randomized controlled trial ( RCT ) nested within a 13-month longitudinal cohort study.
METHODS : Design : Feasibility study.
METHODS / DESIGN : Healthy old people ( n = @number@ ) between the age of @number@ to @number@ years will participate in this trial.
METHODS : DESIGN : Longitudinal study.
METHODS / DESIGN : SPEC is a prospective stepped-wedge cluster randomized trial conducted at @number@ nursing homes in South Korea.
METHODS / DESIGN : STUDY DESIGN : Randomized-controlled trial.
METHODS / DESIGN : The Canadian HIV and Aging cohort is a prospective , controlled cohort study funded by the Canadian Institutes of Health Research.
METHODS / DESIGN : The design of this study is a single-blind randomized controlled trial in thirteen physiotherapy practices.
METHODS / DESIGN : The overall experimental design of the AVEC trial is a 3-arm double blind randomized controlled clinical trial.
METHODS / DESIGN : The proposed study aims to provide insight into the efficacy of CTA in HF patients.
METHODS / DESIGN : The SENIORLAB study is an observational , prospective cohort study.
METHODS / DESIGN : The study design is a 48-week randomised controlled trial consisting of a 24-week intervention with a 24-week follow-up.
METHODS / DESIGN : The study is a two-armed , parallel cluster-randomized controlled trial.
METHODS / DESIGN : The study will be a 1 : 1 parallel-group randomised controlled superiority trial conducted in a rural municipality in Norway.
METHODS / DESIGN : The study will enroll @number@ participants in two Canadian provinces , Ontario and Alberta.
METHODS / DESIGN : This study has a descriptive , analytical , and experimental design.
METHODS / DESIGN : This trial is a multicenter , prospective , randomized , placebo-controlled , open-label , two-parallel group study.
METHODS / DESIGN : This trial is a randomized , controlled study.
METHODS / DESIGN : We chose to contact all @number@ people born between 1935-39 residing in Abbiategrasso , Milan , Italy.
METHODS : Detailed searches of a number of online databases comparing operative and non-operative groups were performed.
METHODS : detection and recognition threshold levels , basic taste identification and ' just about right ' level of sweetness were examined.
METHODS : Detrusor smooth muscle strips were prepared from the macroscopically unaffected bladder wall of patients underwent cystectomy.
METHODS : D-flow was induced in the carotid arteries of young and old mice of both sexes.
METHODS : Dietary intake and clinic data from @number@ men and women ( ages 67-93 years ) from the Framingham Original Cohort Study were analyzed.
METHODS : Diffusion-weighted imaging and streamline tractography of the fornix were performed on @number@ healthy , right-handed females ( 23-66 years ) .
METHODS : Digital CT images from a clinical trial on treatment of IPA were re-evaluated and compared with available biomarkers.
METHODS : Disability was the primary outcome and measured with the modified Katz ADL-index score.
METHODS : Disinfectant use was assessed by questionnaire in @number@ nurses.
METHODS : DNA was amplified and the single-nucleotide polymorphisms in AQP-4 gene were investigated by melting curve analysis using real-time polymerase chain reaction.
METHODS : DTT was performed in @number@ healthy subjects aged 7-45 years.
METHODS : During the PubMed search , we selected studies that examined and compared ET effects with and without administration of commonly used AO supplements.
METHODS : Dynamic mechanical thermal analysis ( DMTA ) tests were performed on a Diamond Dynamic Mechanical Thermal Analyzer in bending mode.
METHODS : Eating frequency , the average number of reported daily eating occasions , was assessed using two weekday 24-h diet recalls.
METHODS : ECFCs isolated from the cord blood of control and GDM pregnancies were assessed for proliferation , senescence , and Matrigel network formation.
METHODS : Echocardiography was performed in @number@ normal subjects who were divided into five groups according to age.
METHODS : E-cig aerosols were analyzed on-line using a Thermal Desorption Aerosol Gas Chromatograph.
METHOD : Secondary data analysis of the imputed 5-year and 34-year data was carried using multivariate logistic regressions.
METHOD : Secondary data on Texas board-certified geriatricians and geriatric psychiatrists from American Board of Medical Specialties database were analyzed.
METHODS : Edmonton stores belonging to each of nine Canadian pharmacy chains were visited to identify NHPs marketed for the relief of menopausal symptoms.
METHODS : EEG was obtained and neuropsychological performance assessed in @number@ patients with AD.
METHODS : eGFR , 24-h Ccr , and CG were calculated in @number@ patients with thoracic malignancies.
METHODS : EGFR gene overexpression was assessed by FISH analysis ; patients with high polysomy or gene amplification were considered FISH positive.
METHODS : eighteen databases were searched with a customised search strategy.
METHODS : Eighteen ( @number@ F , @number@ mol / L ) participants completed a placebo-controlled , 2-period study.
METHODS : Eighteen patients with moderate cataract were included in a prospective study.
METHODS : Eighteen subject matter experts participated in development using a modified Delphi process.
METHODS : Eight geriatric and internal medicine wards were randomized to intervention ( e-learning educational program ) or control.
METHODS : Eight-hundred and one men at the mean age of @number@ ± @number@ years were examined.
METHODS : Eight patients ( @number@ with T2 DM ) were studied before and after RYGB.
METHODS : Eight patients ranging in age from @number@ to @number@ years suffered singular eyelid defects of different causes.
METHODS : Eight waves of reinterviews ( 1995-2010 ) were linked to Medicare claims for @number@ self-respondents yielding @number@ person-period observations.
METHODS : Eighty-five BD patients and @number@ healthy controls were paired for age , sex and educational level.
METHODS : Eighty four patient / caregiver dyads with Alzheimer's disease were recruited through a memory clinic.
METHODS : Eighty lids in @number@ patients were subjected to this surgery from @date@ to @date@ .
METHODS : Eighty mesial-occlusal-distal dental cavities were restored with four direct nanohybrid composite materials and with four nano- and micro-hybrid lab-fabricated resin composite inlays.
METHODS : Eighty-nine patients with MDD were administered paroxetine and completed the 6-week protocol.
METHODS : Eight young subjects ( @number@ ± @number@ years ) and seven older subjects ( @number@ ± @number@ years ) participated in this study.
METHODS : Eighty patients were examined monthly with SDMT for @number@.2±8.4 months.
METHODS : Eighty patients were randomized to home-based and supervised exercise programs , and @number@ finished with complete exercise intervention data.
METHODS : Eighty patients with glaucoma and @number@ with dry eye were enrolled ; @number@ healthy subjects served as controls.
Methods : : Eighty-seven subjects aged > @number@ years were recruited using a community-based convenience sampling strategy in Porto Alegre , Brazil.
METHODS : Eighty-three men with ED due to T2DM were included in the study.
METHODS : Eighty-two patients underwent treatment for a spinal epidural abscess between @number@ and @number@
METHODS : Eighty-two patients were categorized into @number@ groups according to their age.
METHODS : Elderly aged ≥60 years were included from Living Profiles of Older People Survey ( LPOPS ) in Korea.
METHODS : Elderly euthymic patients with bipolar disorder or schizophrenia were assessed using the BACS and a standard cognitive test battery.
METHODS : Elderly , hospitalized coronary artery disease patients on regular aspirin treatment were enrolled from @date@ to @date@ .
METHODS : Elderly patients with dementia visiting our center were recruited.
METHODS : Elderly subjects over @number@ years old were included in the study.
METHODS : Elderly unassisted patients aged ≥65 prescribed five or more prescription drugs were included in the study.
METHOD : Selective literature review including current regulations , guidelines and recommendations for cataract surgery.
METHODS : Electromyography ( EMG ) signals of leg and trunk muscles were recorded.
METHODS : Electronic databases ( MEDLINE / PubMed , CINAHL , EMBASE and PsycINFO ) , were searched for studies published between @number@ and @number@
METHODS : electronic databases were searched using MeSH terms and relevant keywords.
METHODS : Electronic search for articles on AFFs and bisphosphonates published in English was performed.
METHODS : Eleven elderly women ( mean age @number@.1±5.3 years ; mean height @number@.5±4.0 cm ; mean weight @number@.2±9.0 kg ) were enrolled.
METHODS : Eleven elite rowers were assessed during controlled training on a standard rowing machine while wearing control , low-density or high-density textured insoles.
METHODS : Eleven patients with facial laxity were treated with IFUS and evaluated before and after treatment.
METHODS : Eleven women who were undergoing abdominoplasty were considered.
METHOD : Self-completed data from @number@ Australian adults aged 45 + years.
METHOD : Self-reported anthropometric data from @number@ community-dwelling participants ( mean age @number@ years ) were compared with technician measurements.
METHODS : Eligible studies were identified via computer searches and reviewing the reference lists of the key articles.
METHODS : ELSA is a population-based study of English adults aged ≥ @number@ years.
METHOD : Semistructured interviews using a phenomenological approach were conducted with @number@ residents of a LTC home.
METHOD : Semistructured interviews were conducted with a sample of @number@ anti-aging practitioners drawn from the directory of the American Academy for Anti-Aging Medicine.
METHOD : Semi-structured interviews were conducted with fifteen teenagers.
METHOD : Semi-structured interviews were conducted with @number@ family caregivers of community-dwelling people with dementia.
METHOD : Semi-structured interviews were conducted with @number@ participants from @number@ organisations providing care and support to older people in a rural region of Australia.
METHOD : semi-structured interviews were conducted with @number@ patients who were recruited from four general practices located in Sydney , Australia.
METHODS : Empirical observational study including follow-up interviews.
METHODS : End points were mean concentrations , deconvolved secretion , and approximate entropy ( ApEn ; a regularity measure ) of GH.
METHODS : Entity microscope was used to evaluate the extent of periodontal bone resorption.
METHODS : EPCs were isolated from human circulating mononuclear cells from healthy young and aged volunteers.
METHODS : Epidemiological , cross-sectional household-based study carried out with @number@ elderly of both sexes ( @number@ to @number@ years ) .
METHOD : SEPs to median nerve stimulation were repeatedly examined in @number@ genetically diagnosed ULD patients with the mean interval of @number@ years.
METHOD : Sequential explanatory mixed method design.
METHOD : Serum sclerostin levels were measured using the MesoScale Discovery chemiluminescence assay.
METHODS : Essential tremor cases and controls were enrolled in a study of the environmental epidemiology of ET at Columbia University Medical Center.
METHODS : Estimates of mortality and morbidity were obtained from a previous assessment of Australia's health from @number@ to @number@ including projections to @number@
METHODS : Ethical approval was obtained for this retrospective study.
METHODS : European Society Hypertension guidelines were used as a 5-stage risk score.
METHODS : Evaluations included neuropsychological testing , grip strength , balance assessed by the Wii Balance Board , and actigraphy.
METHOD : Seventeen patients with pathologically proven frontotemporal lobar degeneration ( FTLD ) associated with C9ORF72 mutations were identified from Neurodegenerative Disease Brain Bank.
METHOD : Seventy older healthy adults ( ages 60-83 ) varying in musical activity completed a comprehensive neuropsychological battery.
METHOD : Seven women aged 60-65 living in the Faroe Islands were interviewed to elaborate on daily living with long-term UI.
METHODS : Every patient who underwent a LRCP between @date@ and @date@ in the urology department of the University Public Hospital was evaluated.
Methods examined included the Suchey-Brooks method of aging the symphyseal face of the os pubis ( Brooks and Suchey , Hum.
METHODS : Excision of the designed area results in an earlobe flap which can be rotated in the excision defect.
METHODS : Existing data collected by a prospective , closed-panel cohort study of aging and oral health in adult males was used.
Methods : Experienced geriatrics researchers and clinical trialists collaborated to provide advice on clinical trial design.
METHODS : Exploratory and confirmatory factor analyses were utilized to assess the factor structure and the construct validity of the SAI-K.
METHODS : Extensive literature review.
METHODS : Extracted human third molars had their mid-coronal dentin exposed flat and polished with 600-grit SiC paper.
METHODS : Ex-vivo skin samples were treated topically with different retinoid formulations.
METHODS : Eyes of @number@ healthy participants between @number@ and @number@ years old were measured using Corvis and ORA.
METHODS : Eysenck Personality Inventory was used at both occasions.
METHODS : Faces of @number@ healthy Japanese male volunteers , in their 20s-60s , were photographed at an angle of 45°.
METHODS : Facial bone computed tomographic scans were obtained from @number@ female and @number@ male Caucasian subjects.
METHODS : Facial photographs were taken under a shadowless lamp from three directions using a high-resolution digital camera.
METHODS : Facial signs ( structural and pigmentation-related ) were scored in blind by a panel of @number@ experts from photographs taken under standard conditions.
METHODS : Factors that were examined included age , gender , time of last meal or drink , and recent consumption of coffee.
METHODS : Fibroblasts were cultured with and without CK ( @number@ μM , @number@ μM or @number@ μM ) for @number@ hours.
METHODS : Fifteen cases were retrospectively analyzed treated from @date@ to @date@ .
METHODS : Fifteen patients diagnosed with congenital aniridia and a control group of forty volunteers were studied.
METHODS : Fifteen patients with AD , @number@ subjects with aMCI and @number@ Healthy Controls ( HC ) received the RCPM.
METHODS : Fifteen patients with small intracranial tumors were retrospectively studied.
METHODS : Fifteen premanifest HD subjects and @number@ controls were compared on the NIH EXAMINER executive function battery.
METHODS : Fifteen QSRs , two malls , and @number@ eligible parents were approached to participate in the study in @number@
METHODS : Fifteen SNPs were genotyped in the MASP1 gene in @number@ blood donors.
METHODS : Fifteen young adults and @number@ community-dwelling elderly adults participated in this study.
METHODS : Fifteen young and @number@ older volunteers performed rapid forward steps while standing on a force platform.
METHODS : Fifteen younger ( 20-50 yr ) and @number@ older ( ≥70 yr ) patients were sequentially enrolled in this study.
METHODS : Fifteen younger adults and eight older adults participated in the study.
METHODS : Fifty adult cadavers were included in this descriptive analytic study.
METHODS : Fifty bariatric patients were recruited from the Longitudinal Assessment of Bariatric Surgery parent project.
METHODS : Fifty control subjects and @number@ patients who underwent total laryngectomy for advanced laryngeal carcinoma were evaluated.
METHODS : Fifty-eight Haiti residents ( @percent@ women ) in four age groups , 18-30 , 31-50 , 51-64 , and ≥ @number@ years participated.
METHODS : fifty-eight health professionals participated in eight focus groups and four semi-structured interviews.
METHODS : Fifty-five participants with TEA were recruited from The Impairment of Memory in Epilepsy project database.
Methods : Fifty MCGP were enrolled , @number@ patients with dry eye , and @number@ healthy subjects served as controls.
METHODS : Fifty-nine patients ( @number@ eyes ) with PACG and @number@ age-matched normal subjects underwent macular CT scanning using enhanced depth imaging-optical coherence tomography.
METHODS : Fifty older adults ( age 65-89 years ) without any confounding neuromuscular impairment were randomly assigned to a training group or no-training group.
METHODS : Fifty patients with osteoporosis were divided into two groups.
METHODS : Fifty-seven AMD patients with bilateral , or severe unilateral , visual impairment were compared to @number@ controls with normal vision.
METHODS : Fifty-six consecutive patients undergoing SmartLipo with facelift were reviewed using pre-operative photographs as a baseline.
METHODS : Fifty-three healthy participants were recruited randomly.
METHODS : Fifty-three patients underwent this facelift procedure.
METHODS : Fifty-three PD patients without dementia were recruited to participate in a 3-year longitudinal cohort study.
METHODS : Fifty university students ( ages 18-26 ) and @number@ community-dwelling older adults ( ages 62-86 ) were tested.
METHODS : Fifty volunteers from @number@ to @number@ years old were divided into five consecutive age groups ; a young group and four senior groups.
METHODS : Finite element methods and ray-tracing algorithms were used to model the deformation and optical power of the human crystalline lens during accommodation.
METHODS : Finite element method simulations were performed for evaluation of the impedance.
METHODS : First , participants responded to questions regarding their beliefs about attitude-behavior consistency.
METHODS : First , total difference minimization ( TDM ) was implemented using the soft-threshold filtering ( STF ) .
METHODS : First , we performed a meta-analysis on formal education and VCI , identifying @number@ studies ( N = 7770 ) .
METHODS : Five age groups of pediatric patients and adult patients were simulated by three organ dose estimators.
METHODS : Five databases ( SCOPUS , Cochrane , PsycINFO , PubMed and CINAHL ) were searched for articles published between @date@ and @date@ .
METHODS : Five healthy adult men participated in the pilot study phase and @number@ in the definitive intervention trial.
METHODS : Five patients were enrolled in this study.
METHODS : Five studies from @number@ to @number@ were pooled to include @number@ adults aged ≥65 years with diagnosed chronic diseases measured by self-administered questionnaire.
METHODS : Five subjects with severe symptomatic secondary mitral regurgitation underwent mitral loop cerclage , with echocardiographic and computed tomography follow-up over @number@ months.
METHODS : Fluorimetric and spectrophotometric assays were performed in urine samples of @number@ healthy smokers and @number@ age-matched controls.
METHODS : Foam posturography was performed in @number@ VN patients.
METHODS : Focus group discussions occurred among @number@ men and women between the ages of @number@ and @number@ years old.
METHODS : Focus group interviews were conducted with healthcare professionals who , after being trained , applied the SDM framework.
METHODS : Following a sevoflurane induction , heart rates were recorded every @number@ s for @number@ min in @number@ ASA I-II children under age @number@
METHODS : Following ethical approval , @number@ patients were randomly assigned into either a CCF group or a CF group.
METHODS : Following PRISMA guidelines a systematic review of epidemiological observational studies and clinical trials was undertaken.
METHODS : Follow-up of ALEXANDROS cohorts designed to study disability associated with obesity in community-dwelling people @number@ years and older living in Santiago , Chile.
Methods for bowel care remained surprisingly stable but a large proportion had undergone stoma surgery.
METHODS : For each case series , @number@ female subjects were enrolled.
METHODS : Formalin-fixed lung tissue from patients who had lobectomy for bronchial carcinoma was used to investigate the presence of AGEs and RAGE.
METHODS : For normal spinal measurements , @number@ patients who underwent a posteroanterior chest radiographs were evaluated.
METHODS : For @number@ adults in this study , anthropometric indices , such as BMI and WC , were measured.
METHODS : For the purpose of this review , ICU patients , patients in hematology and oncology wards and transplant recipients were considered high-risk.
METHODS : For the years @number@ to @number@ we performed a population-based cross-sectional survey with a multistage cluster sampling design.
METHODS : For this purpose , OC patients were prospectively enrolled from @date@ to @date@ , following OC criteria.
METHODS : For this purpose , two apparatus , one for adherent cells and the other for intact rat aorta , were designed and produced.
METHODS : Forty adults , aged 40-60 years , performed a 2-Back working memory task during fMRI.
METHODS : Forty-eight consecutive patients referred to our unit for obscure-overt GI bleeding from @date@ to @date@ were prospectively evaluated.
METHODS : Forty-five adult non-demented Down syndrome patients showing a wide age range ( 18-52 years ) and a matched 45-subject control group were assessed.
METHODS : Forty-five patients are presented who underwent medial thigh contouring with liposuction-assisted medial thighplasty.
METHODS : Forty-five patients received a range of 2-3 treatments in the upper , lower eyelids and periorbital area with a fractional laser device.
METHODS : Forty-five subjects have been evaluated twice @number@ years apart for hemorheological parameters and coronary heart disease ( CHD ) risk factors.
METHODS : Forty four elderly inpatients ( mean age @number@ yrs ) after hip fracture or stroke were recruited for the study.
METHODS : Forty-four eyes of @number@ healthy subjects were investigated in this study.
METHODS : Forty-four participants ( @number@ young ; @number@ old ) completed both protocols in a randomised , counter-balanced , crossover design.
METHODS : Forty male SD rats were randomized equally into negative control group , D-galactose group , EPO treatment group , and positive control group.
METHODS : Forty-nine premenopausal women , @number@ perimenopausal women and @number@ postmenopausal women were enrolled in one study.
METHODS : Forty normal subjects underwent Topcon 3D @date@ macula-centered scan.
METHODS : Forty normal volunteers with a mean age of @number@ ± @number@ years were recruited for this study.
METHODS : Forty OADM subjects ( mean age @number@ ± @number@ ) complicated by V-CSH were recruited.
METHODS : Forty-one older adults were recruited from local retirement villages and educational settings to participate in a six-week two-group repeated measures study.
METHODS : Forty-one subjects received FCT to temporal branches of the facial nerve.
METHODS : Forty-seven care clients met the inclusion criteria.
METHODS : Forty-seven human subjects were examined and their medical history was explored.
METHODS : Forty-six subjects with mild-to-moderate facial dyschromia and rhytides were evenly randomized to two Er : YAG treatment arms.
METHODS : Forty-three chemotherapy-refractory Japanese patients with mCRC were treated with cetuximab monotherapy or cetuximab plus irinotecan.
METHODS : Forty-two extracted human molars were selected and occlusal dentin surfaces were exposed.
METHODS : Forty-two subjects ( 67-88 years ) from the geriatric ambulatory unit were submitted and @number@ subjects completed the glucagon stimulation test.
METHODS : Four different conditions were presented : ( @number@ ) N-H : a neutral face that suddenly changed to a happy face.
METHODS : Four focus groups consisting of @number@ home-care assistants were conducted.
METHODS : Four hundred eighty transvenous lead extraction procedures performed from @date@ through @date@ at Mayo Clinic ( Rochester , Minnesota ) were retrospectively reviewed.
METHODS : Four hundred eighty-two eyes of @number@ patients with keratoconus were separated into @number@ groups based on age.
METHODS : Four hundred fifty-six healthy volunteers were randomly recruited.
METHODS : Four hundred seven women underwent clinical evaluation , polysomnography , and biochemical analysis.
METHODS : Four hundred sixty-three non-Hispanic white individuals exceeding quality control criteria were included from the Alzheimer's Disease Neuroimaging Initiative ( ADNI-1 ) cohort.
METHODS : Four hundred thirty-nine healthy Caucasian children participated.
METHODS : Fourteen nursing homes were selected from various areas of Taiwan by purposive sampling.
METHODS : Fourteen older adults were randomly assigned to participate into one of the two intervention groups.
METHODS : Fourteen patients ( @number@ sites ) were assessed.
METHODS : Fourteen patients with OSAS and @number@ with RLS were compared to @number@ age-matched controls.
METHODS : Fourteen specialists in aesthetic medicine convened over a full-day meeting under the guidance of a certified moderator.
METHODS : Fourteen young and @number@ older adults raised the arms in response to the target sound signal.
METHODS : Fourteen younger ( mean @number@ yr ) and @number@ older ( mean @number@ yr ) males participated in the study.
METHODS : Four thousand six hundred and ninety participants of The Irish Longitudinal Study on Ageing ( TILDA ) were studied.
METHODS : Frailty and persistent pain were operationalized using data from the Health and Retirement Study ( 2006-2012 waves ) .
METHODS : Frequencies of peripheral blood monocyte subpopulations were analyzed by flow cytometry in @number@ healthy controls and @number@ RA patients.
METHODS : From a cohort of @number@ elderly patients , patients who experienced a suspected medication related incident ( n = 87 ) were selected.
METHODS : From a community-based random sample of 75-year-old men and women , subjects with normal LVEF were selected ( n = @number@ ) .
METHODS : From @date@ to @date@ , all data of patients admitted for more than @number@ hours were collected.
METHODS : From @date@ to @date@ , a total of @number@ community-dwelling elderly subjects ( aged > 65 years ) from northern Shanghai were recruited.
METHODS : From @date@ to @date@ computed tomography ( CT ) images of @number@ patients were reviewed in this retrospective study.
METHODS : From @date@ to @date@ , consecutive first-ever AIS patients admitted to the Department of Emergency of our hospital were identified.
METHODS : From @date@ to @date@ , @number@ female patients underwent the minimal incision midface lift procedure.
METHODS : From @date@ to @date@ , @number@ general practitioners administered the Mini-Mental State Examination ( MMSE ) to patients presenting with first cognitive complaints.
METHODS : From @date@ to @date@ , @number@ patients ( @number@ knees ) with knee pain post TKA were treated.
METHODS : From @date@ to @date@ , @number@ patients with HCC underwent hepatectomy were analyzed retrospectively.
METHODS : From @date@ to @date@ , @number@ patients with pancreatic cystic tumors in our center were reviewed retrospectively.
METHODS : From @date@ to @date@ , @number@ pregnant women from @number@ national wide cooperative hospitals were involved in this prospective research.
METHODS : From @date@ to @date@ @number@ second- and recent-generation EPs were collected as a part of a European collaborative retrieval program.
METHODS : From @date@ to @date@ , the hospice palliative care team at a community hospital received @number@ consultations for CE.
METHODS : From December of @number@ to December of @number@ @number@ patients underwent this procedure.
METHODS : From January to @date@ , we have treated @number@ patients.
METHODS : From @number@ participants initially enrolled in The Lothian Birth Cohort Study @number@ we obtained whole diet data from @number@
METHODS : From @number@ residents aged @number@ years and older of Banciao Veterans Home were invited for study and were followed for @number@ years.
METHODS : From @number@ to @number@ @number@ community-dwelling individuals ( ≥60 years ) were followed-up.
METHODS : From @number@ to @number@ @number@ patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention were retrospectively analyzed.
METHODS : From @number@ to @number@ patients on anti-TB treatment were identified and their medical records reviewed.
METHODS : From @number@ to @number@ we admitted @number@ patients with ruptured cerebral aneurysm.
METHODS : From our dedicated PCI registry we identified @number@ ACS patients with high-risk lesions that were treated with PCI.
METHODS : From the literature searches , @number@ studies on everyday functioning and @number@ studies on memory were obtained.
METHODS : From the population-based prospective study SNAC-K , @number@ diabetes-free participants aged ≥60 years were identified and followed up for @number@ years.
METHODS : From the surgical database , all patients operated on in the authors ' department for gelsolin amyloidosis from @number@ to @number@ were included.
METHODS : FSW completed a questionnaire that included a retrospective question regarding the age at which they started selling sex.
METHODS : Functional status in octogenarians and nonagenarians was assessed at seven occasions with intervals of 2-3 years.
METHODS : FVC and FEV1 were measured one to six times during the period 1995-2011 in @number@ men participating in the Normative Aging Study.
METHODS : Gait speed was assessed in @number@ subjects with right MCA infarct , @number@ with left MCA infarct , and @number@ controls.
METHODS : Genetic risk scores from these loci were calculated for @number@ cases.
METHODS : Genotype associations with knee OA severity were assessed in two Caucasian populations.
METHODS : Genotyping for rs1801133 was performed with PCR-RFLP techniques.
METHODS : Geriatric rehabilitation patients admitted to a general metropolitan hospital following a fracture were interviewed face-to-face.
METHODS : GRASE-derived multiecho images were analysed using dedicated software.
METHODS : Growth curve models are applied to the English Longitudinal Study of Ageing waves @number@ to @number@
Methods : Guided by a community-based participatory research approach , @number@ Chinese adult children aged @number@ years and older participated in this study.
METHODS : HaCaT cells were treated with apigenin and luteolin for the indicated times followed by irradiation with UVA.
METHODS : Hand grip strength was cross-sectionally evaluated between @number@ and @number@ to assess muscle strength in @number@ male workers aged @number@ to @number@ years.
METHODS : HbA1c is a marker used for the diagnosis and management of diabetes.
METHODS : HCECs were dissected from the corneas of young ( @number@ years and younger ) and older ( @number@ years and older ) donors.
METHODS : Heads of @number@ fetal specimens of 14-40 weeks gestational age ( GA ) were scanned by @number@.0T MRI.
METHODS : Health and Aging in Africa : A Longitudinal Study of an INDEPTH Community in South Africa is a cohort of @number@ adults.
METHODS : Healthy adult Japanese volunteers were recruited for this study.
METHODS : Healthy children were prospectively included between May and @date@ .
METHODS : Healthy patients with normal liver and kidney function were selected based on biochemical variables.
METHODS : Healthy postmenopausal women ( n = @number@ mean age , @number@ ± @number@ years ) were enrolled in this study.
METHODS : Healthy subjects and patients with COPD of different severity were recruited.
METHODS : Healthy subjects ( N = @number@ ) , aged @number@ to @number@ years , were recruited.
METHODS : Helicobacter pylori-positive patients underwent a 10-day therapy randomized into four groups : Group A received esomeprazole , amoxicillin , and DOX-100 mg b.i.d.
METHODS : Hemodynamic response to metaboreflex activation obtained by post-exercise muscle ischemia ( PEMI ) was gathered in @number@ EG and @number@ healthy CTL.
METHODS : hES-RPE of @number@ degrees of pigmentation and fRPE were cultured on BM explants.
METHODS : Hierarchical linear models were used to analyze the cross-sectional data from the nationally representative population-based Medical Expenditure Panel Survey.
METHODS : HI injury was induced in 7-d-old pups by ligating the common carotid artery followed by exposure to @percent@ oxygen for @number@ h.
METHODS : Histologies were obtained from non-lasered facial and non-facial skin from @number@ patients and from @number@ samples of excised lasered thigh skin.
METHODS : Histopathological findings of endomyocardial biopsy from @number@ pediatric patients with DCM were analyzed and compared with those in adult patients.
METHODS : HIV-infected individuals and uninfected controls from the AGEhIV Cohort Study were screened for the presence of comorbidities.
METHODS : HIV-infected individuals were recruited from the outpatient clinic in University Malaya Medical Centre , Malaysia and controls from the community.
METHODS : Homebound older adults receiving meal service who endorsed depressive symptoms were interviewed to assess depression severity and rates of suicidal ideation.
METHODS : Home visits were made to @number@ community-dwelling seniors living in the Netherlands , on three occasions ( 2012-2014 ) .
METHODS : HPF cells were continuously cultured and subcultured in vitro to build replicative cellular model.
METHODS : HPLC was employed to analyze the constituents of FPKc.
METHODS : Human bone marrow-derived ( bmMSCs ) and umbilical cord-derived ( ucMSCs ) MSCs were in vitro expanded.
METHODS : Human dental pulp cells were isolated , cultured as usual , and used from the 4 ( th ) passage.
METHODS : Human erythrocytes were separated into five fractions , based on age-associated characteristics cell density and volume.
METHODS : Human OA synovia were obtained from eight patients undergoing hip joint replacement.
METHODS : Human PDA cell lines were engineered to express an inducible form of the bHLH protein E47.
METHODS : Human prostate cancer and normal cell lines were used.
METHODS : Human skin samples were collected and treated ex-vivo with the HE applicator.
METHODS : Human WJ-MSCs and normal skin fibroblasts were isolated from donated umbilical cords and normal adult human skin.
METHODS : Hyaluronic acid , semi-permanent fillers , such as calcium hydroxylapatite , and permanent fillers , such as polyalkylimide / polyacrylamide , were used.
METHODS : Hydrogen peroxide treatment was used to induce senescence in the human HepG2 hepatocyte cell line.
METHODS : Hyperplastic parathyroid glands ( n = @number@ ) were obtained from @number@ patients who received parathyroidectomy due to secondary renal hyperparathyroidism.
METHODS : Hypotheses were tested in @number@ dyads consisting of patients and their friends or relatives ( informants ) recruited from primary care settings.
METHODS : IL-6 expression and ROS generation were assayed in UVB-irradiated keratinocytes.
METHODS : Immune cell frequencies and phenotypes were determined in @number@ HDV-infected patients , @number@ individuals with hepatitis B virus monoinfection and @number@ healthy controls.
METHODS : Immune molecules were evaluated in monocytes of AD , LOD patients , and controls using flow cytometry.
METHODS : Immunohistochemistry and western blotting were used for detecting and locating trypsin isoforms in the vitreous and retina of human donor eyes.
METHODS : Immunohistochemistry for CD44s , CD44v3 and CD44v6 was retrospectively performed on formalin-fixed paraffin wax-embedded breast cancer tissue samples.
METHODS : Immunohistochemistry ( IHC ) and western blotting were performed to detect the expression level of Klotho in DLBCL patients and cell lines.
METHODS : In 1992-1993 , we studied EEG and cognition in @number@ diabetic children and @number@ matched controls.
METHODS : In 1996-1997 , serum CML was measured in @number@ Cardiovascular Health Study participants ( mean age @number@ ± @number@ years ) .
METHODS : In a 24-month period out of @number@ patients there were @number@ and @number@ patients with and without acute myocardial infarction , respectively.
METHODS : In a 2-year weight loss trial , subjects were randomized to one of four diets that varied in macronutrient content.
METHODS : In accordance with PRISMA guidelines , we used the following databases : MEDLINE , EMBASE , and CINAHL.
METHODS : In a clinical setting , @number@ volunteers of different age groups were examined using MPT.
METHODS : In a cohort of @number@ parkinsonian patients the incidence and outcome of AC was prospectively assessed.
METHODS : In a cross-sectional analysis , @number@ outpatients with AD ( mean Mini-Mental State Exam score : @number@ ) were studied.
METHODS : In a cross-sectional study among @number@ adults , masticatory function was investigated using a validated questionnaire.
METHODS : In a cross-sectional study using random cluster sampling on @number@ schools in Dezful ( clusters ) , @number@ clusters were selected.
METHODS : In a double-blind randomised controlled trial we enrolled individuals aged 60-77 years recruited from previous national surveys.
METHODS : In a double blind , randomized study , @number@ middle-aged males received either placebo or fluvastatin ( 10mg ) for @number@ days.
METHODS : In an area with a borderline iodine status in the past , we studied @number@ participants of the Nijmegen Biomedical Study.
METHODS : In a randomized controlled trial , participants were randomized 1 : 1 to view an appearance-based video or a health-based video.
METHODS : In a retrospective analysis all patients with AKI admitted to a tertiary care Nephrology department ( N = 424 ) were included.
METHODS : In both countries , interviews were conducted with samples of @number@ persons of @number@ years and over in villages of similar socio-economic status.
Methods included interviews and focus groups with seniors and professionals.
METHODS : In cross-sectional sampling , @number@ @number@ German-speaking Swiss individuals were contacted.
METHODS : In @date@ , informational alerts were integrated into the CPOE system for selected high-risk medications : diphenhydramine , metoclopramide , and all antipsychotics.
METHODS : In-depth interviews were conducted with @number@ residents of an elder cohousing community in @number@
METHODS : Individual data on trust were collected from @number@ @number@ adults in @number@ countries.
METHODS : Individual participant data analysis was performed after a systematic literature search in MEDLINE / EMBASE ( 1946-2016 ) .
METHODS : Individual participant data meta-analysis included @number@ participants ( @percent@ women ) , from seven prospective cohort studies , free from cancer at enrollment.
METHODS : individuals aged 60-86 years ( n = @number@ ) were randomly selected from the Tasmanian electoral roll.
METHODS : individuals were from the Medical Research Council Cognitive Function and Ageing Study.
METHODS : Individuals with a self-reported history of stroke were identified from the National Health and Aging Trends Study.
METHODS : Individuals with T2DM who were currently using one or more devices to monitor their disease participated in focus groups.
METHODS : Inflation tests on posterior scleral shells were performed while full-field , three-dimensional displacements were recorded using laser speckle interferometry.
METHODS : Information on food consumption and other lifestyle factors was collected from Japanese older persons aged ≥65 years via a questionnaire.
METHODS : Information regarding the sexual experiences of a nationally representative sample of men and women over age @number@ within the past year was examined.
METHODS : Information was collected from @number@ patients who underwent liver biopsy.
METHODS : Informed consent was obtained from @number@ physicians.
METHODS : Infrared spectra of meibum from @number@ normal donors were acquired.
METHODS : In-home interviews were conducted with @number@ participants aged @number@ and older who were completing an eligibility interview for a randomized control trial.
METHODS : In @number@ a 2-year follow-up study was conducted with the @number@ Montreal Neighborhood Networks and Healthy Aging Study ( MoNNET-HA ) participants.
METHODS : In @number@ a stratified random sample of NHSC clinicians was surveyed.
METHODS : In @number@ a survey was mailed to @number@ heads of department of the IMD of @number@ Spanish public hospitals.
METHODS : In @number@ MCI patients , followed to ascertain AD progression , markers were measured.
METHODS : In @number@ @number@ community-dwelling people aged @number@ years and older were included as part of the KORA-Age study.
METHODS : In @number@ @number@ Danish twin pairs ( n = @number@ ) aged 70 + years were photographed generating passport-type images.
METHODS : In @number@ @number@ facilities associated with the University of Pittsburgh Institute on Aging established a quality improvement network addressing immunization rates.
METHODS : In @number@ patients ( @number@ ± @number@ years , @percent@ male ) , retrospectively-gated MDCT were performed.
METHODS : In @number@ physically active Japanese subjects ( 7-79 years ) with no impairment of daily activities were performed counter-movement jumps.
METHODS : In @number@ population-based cross-sectional surveys were carried out in @number@ municipalities in Västerbotten , Sweden and @number@ municipalities in Ostrobothnia , Finland.
METHODS : In older veterans admitted to a tertiary VA hospital , delirium risk was assessed using cognitive impairment , vision impairment , and dehydration.
METHODS : In order to determine the consequences of reduced collagen crosslinking , in vitro models of reduced collagen crosslinking were established.
METHODS : Inpatients aged over @number@ years with atrial fibrillation ( AF ) were recruited.
METHODS : In protocol @number@ RT3DE data sets and CMR images were acquired on the same day in @number@ patients referred for clinically indicated CMR.
METHODS : Insurants of a large German health insurance company aged 65 + years were included in a retrospective matched cohort study.
METHODS : International guidelines for creating PRO instruments were strictly observed throughout development of the FACE-Q scales.
METHODS : Intervention participants ( N = @number@ ) received tailored advice three times within four months , targeting the psychosocial determinants of PA.
METHODS : Interventions included training , interpersonal communication , community mobilization , and mass media.
METHODS : Intervention studies were searched for using six electronic databases for English-language publications from @date@ to @date@ .
METHODS : Interviewer-administered surveys were conducted in @number@ community-dwelling older ( age > 65 years ) adults.
METHODS : Interviewers carried out 90-minute interviews with @number@ nurse aides who worked at an assisted living facility or a nursing home.
METHODS : In the CitAD study , all participants and caregivers received a psychosocial intervention and @number@ were assigned to placebo for nine weeks.
METHODS : In the implementation study ( IMP ) @number@ and RCT @number@ women participated.
METHODS : In the Kungsholmen Project , a population-based cohort study , we followed @number@ persons with incident dementia longitudinally.
METHODS : In the SOD1 total knockout ( SOD1-deficient ) mice , the level of superoxide anion was measured using dihydroethidium.
METHODS : In the Three-City population-based cohort study , @number@ men aged @number@ and over had available baseline data on hormones levels and carotid ultrasonography.
METHODS : In this 3-week pilot clinical study , @number@ sedentary women who met all inclusion criteria were recruited from local communities.
METHODS : In this article , the authors apply their anatomical research and cadaveric studies to demonstrate and support their neck-lift techniques.
METHODS : In this case-control study a total @number@ subjects were included.
METHODS : In this cross-sectional observational study , @number@ Korean healthy subjects aged from @number@ to @number@ years were included.
METHODS : In this cross-sectional observational study , we enrolled subjects over @number@ years.
METHODS : In this cross-sectional study , Alberta workers ' compensation claimants with subacute and chronic work-related musculoskeletal injuries were studied.
METHODS : In this cross-sectional study , CVD risk factors were compared between women with a different menopausal status within the same yearly age strata.
METHODS : In this cross-sectional study , multistage cluster sampling was done from the students of Mashhad University of Medical Sciences.
METHODS : In this cross-sectional study , peripapillary RNFL measurement was performed using a Cirrus SD-OCT device.
METHODS : In this cross-sectional study , we included @number@ individuals @number@ years of age or older from the Brazilian Aging Brain Study Group.
METHODS : In this longitudinal study , @number@ patients with Parkinson's disease were recruited.
METHODS : In this longitudinal study , we assessed changes in ABPV over @number@ years in a community-cohort of older people.
METHODS : In this long-term prospective cohort study , data were retrieved from the Taiwan Longitudinal Study on Aging.
Methods : In this monocentric retrospective observational study , patients affected by nonproliferative SC retinopathy were included from @date@ to @date@ .
METHODS : In this prospective longitudinal study , we investigated a multilocus profile of genetic risk derived from published GWAS of asthma case status.
METHODS : In this prospective , population-based study of people ≥65 years of age , subjects were evaluated at baseline and @number@ years later.
METHODS : In this qualitative study , we used a hermeneutic approach to interpret Gerontion from a psychiatric perspective.
METHODS : In this retrospective , consecutive series , the medical records and photographs of @number@ patients were reviewed.
METHODS : In this study , two datasets with both types of disulfides were compiled using independent approaches.
METHODS : In this study , we calculated the survival rate and measured the spinal curvature through the aging process.
METHODS : In this study , we integrated miRNA and mRNA expression profiles in the human brain across lifespan from the network perspective.
METHODS : In this study were included @number@ patients , mean age @number@ who underwent FESS because affected by CRS not responsive to medical treatments.
METHODS : In total , @number@ colorectal tumors ( @number@ serrated lesions , @number@ non-serrated adenomas and @number@ colorectal cancers ) were acquired from patients.
METHODS : In total , @number@ drugs ( @number@ observations ) were randomly selected for this study.
METHODS : In total , @number@ participants without previously known diabetes were enrolled in this study.
METHODS : In total , @number@ patients with MCI at @number@ participating institutions underwent clinical and neuropsychological examinations , MRI , and 18F-FDG-PET at baseline.
METHODS : In total @number@ subjects participated of this study.
Methods Intramuscular electrodes were inserted into each segment of the GMed and GMin in @number@ healthy , postmenopausal women.
METHODS : In two experiments , younger and older adults performed an active visuo-spatial working memory ( VSWM ) span task.
METHODS : In two identical multicenter , randomized , double-blind , placebo controlled studies.
METHODS : Investigators engaged in an iterative process of independent and group coding until theme saturation was reached.
METHODS : In vitro characterization of recombinant otoconial proteins with respect to crystal growth parameters and solution state behavior.
METHODS : In vitro , exogenous IL-4 was applied to BV2 microglial cell cultures to evaluate the temporal progression of microglial responses.
Methods involved interviews and focus groups with front-line long-term care workers , administrators , and key participants.
METHODS : IOLMaster @number@ was adopted in this study to measure preoperative corneal keratometry.
METHODS : ISI Web of Science was searched for references to bone Raman spectroscopy in peer-reviewed journals.
METHODS : Items from @number@ national fast-food chains were selected : French fries , cheeseburgers , grilled chicken sandwich , and regular cola.
METHODS : It is an observational study , comparing @number@ patients with unexplained fall with @number@ patients with unexplained syncope.
METHODS : It was a hospital-based cross-sectional study.
METHODS : It was an observational cross-sectional study conducted between @date@ and @date@ .
METHODS : It was assessed the effect of tomato and by-products extracts on platelet aggregation induced by ADP , collagen , TRAP-6 and arachidonic acid.
METHOD : Sixteen healthy U.K. centenarian volunteers were interviewed in their place of residence.
METHOD : Sixteen older and @number@ young adults , all healthy , participated in this study.
METHOD : Sixty cognitively healthy adults participated.
METHOD : Sixty-one Australian dementia care staff ( mostly nurses , @percent@ ; and allied health , @percent@ ) were recruited.
METHODS : Kato-Katz fecal smears were examined for parasite presence and infection intensity.
METHODS : Kidney-tonifying Chinese medicines with anti-aging effects were screened from the Chinese Pharmacopoeia and the literatures.
METHODS : Kinematic magnetic resonance images ( @number@ T ) were available for @number@ healthy individuals from @number@ to @number@ years of age.
METHODS : Knee magnetic resonance images were collected from @number@ patients with lateral patellar instability and from @number@ control subjects.
METHODS : Knee X-rays taken from the Baltimore Longitudinal Study of Aging are used in this study.
METHODS : Laparoscopic operations under general anesthesia were undertaken with the patients in lithotomy position.
METHODS : Large-scale , nationally representative , longitudinal data collected from @number@ to @number@ were analyzed for this study.
METHODS : LDL-C concentration was measured at baseline and all-cause mortality was calculated over a 3-year period.
METHOD : Sleep disturbance was assessed with the Jenkins Sleep Scale.
Methods Leisure time physical activity was assessed by a validated questionnaire and our primary exposure was physical inactivity ( PI ) .
Methods : Lenticular AF was imaged with 488-nm excitation using a confocal scanning laser ophthalmoscope ( cSLO ) routinely used for retinal AF imaging.
Methods : Lentiviral siRNA and the genome editing CRISPR / Cas9 system were used to knockout Prom1 in primary RPE and ARPE-19 cells , respectively.
METHODS : Letter recognition thresholds were determined for three different flanker separations in @number@ adults ( aged 18-76 years ) with normal vision.
METHODS : Levels of @number@ individual lipids , across @number@ lipid subclasses , were measured utilising a high-resolution mass spectrometric analysis platform.
METHODS : LF from @number@ lumbar spinal canal stenosis ( LSCS ) patients and @number@ non-LSCS patients ( control group ) were collected during surgery.
METHODS : LIFE-P participants , aged 70-89 years , were at elevated risk of disability.
METHODS : Linear and post-buckling analyses were performed on soft elastic laminate models using the finite element method.
METHODS : Linkage analysis and whole exome sequencing were performed in consanguineous and nonconsanguineous MCPH families to identify disease-causing variants.
METHODS : literature review and case studies.
METHODS : Literature review , consensus meetings , and a retrospective chart review of patients with probable AD were conducted.
METHODS : Literature review of key references selected by author.
METHODS : Literature review of published empirical studies from @number@ to @date@ .
METHODS : Literature review of the last @number@ years.
METHODS : Literature searches were performed in MEDLINE® , PubMed , Cochrane Library , and EMBASE databases for publications from @number@ to @date@ .
METHODS : Longitudinal cohort study using data from the Physical Activity Cohort Scotland.
METHODS : Longitudinal data from the NEXT Study was used.
METHODS : Longitudinal data of smokers from two survey waves of the International Tobacco Control ( ITC ) Europe Surveys were used.
METHODS : Longitudinal data were used from the China Health and Retirement Longitudinal Study ( CHARLS ) .
METHODS : Longitudinal population-based epidemiologic study of @number@ community-dwelling men participating in the Massachusetts Male Aging Study.
METHODS : Longitudinal study of the impact of HF on the functions of polymorphonuclear neutrophils ( PMNs ) in elderly subjects.
METHODS : Lothian Birth Cohort @number@ participants ( N = 1017 ) completed the same general cognitive ability test at ages @number@ and @number@ years.
METHODS : Low back pain , aching or stiffness on most days was documented on a body chart.
METHODS : LTL was measured by quantitative PCR at baseline in @number@ older adults , who were enrolled in a population-based cohort study in Germany.
METHODS : Lung samples from @number@ IPF and @number@ control patients were obtained through surgical lung biopsy.
METHODS : Lung tissues , primary lung cells , ELF and sputum were obtained.
METHODS : Lymphatic vessels with a specialized tube of perilymphatic fat were identified beneath palmar creases.
METHODS : Macular and peripheral RPE cells were isolated and cultured from human donor eyes with and without AMD.
METHODS : Magnetic resonance imaging measurements of MAWT were performed on @number@ free-living white , black , and Hispanic adult subjects.
METHODS : Male participants over @number@ years old were randomly selected from multiple communities in Beijing.
METHODS : Matched case-control study based on five national Swedish registers ( n = @number@ @number@ ) .
METHODS & MATERIALS : Subjects completing the 18-month persistence study were permitted to enroll in an 18-month extension trial.
METHODS & MATERIALS : We studied @number@ human cadaver heads with gross dissections and macroscopic and histological sections.
METHODS : Maximal oxygen uptake ( VO2 max ) was estimated using a step test heart rate method for @number@ participants.
METHODS : Measures of neuropathology and genotyping were available from @number@ deceased participants from the Religious Orders Study and the Rush Memory and Aging Project.
METHODS : Measures of ovarian reserve were day-3 follicle-stimulating hormone ( FSH ) , antral follicle count ( AFC ) , and ovarian volume.
METHODS : Mechanically ventilated medical ICU patients were prospectively enrolled , and blood was collected after enrollment for measurement of IGF-1 using radioimmunometric assay.
METHODS : Medical charts of patients with a discharge diagnosis of AH ( defined using rigorous clinical criteria ) were reviewed.
METHODS : Medically healthy patients aged @number@ to @number@ years old treated with risperidone for at least @number@ months were enrolled.
METHODS : Medical records of mortality cases of culture-proven TB diagnosed during 2003-2007 were reviewed.
METHODS : Medline and Google Scholar searches were conducted for relevant articles , chapters and books published before @number@
METHODS : Medline , EMBASE and CINAHL databases were searched for observational studies that measured FI and mortality in community-dwellers over 65years of age.
METHODS : Medline , EMBASE , and Scopus databases were searched from inception to @date@ .
METHODS : MEDLINE , EMBASE and the Cochrane Library database were used to identify potential studies.
METHODS : Medline , Embase , CINAHL , and Cochrane databases were searched.
METHODS : Medline , Embase , CINAHL and PsycINFO were searched on @date@ .
METHODS : Medline , PsychInfo , Embase and the Cochrane Database were searched for English Language Studies.
METHODS : MEDLINE , PsycINFO , The Cochrane Library and Web of science were searched from @date@ to @date@ .
METHODS : Meetings of the UNAIDS Reference Group include individuals with extensive knowledge of HIV programs , research , statistics , and public policy.
METHODS : Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings.
METHODS : Memory training was given to healthy older adults ( aged 75-85 ) living in a retirement home.
Methods : men aged 40-79 years were recruited from population registers in eight European centres for participation in the European Male Aging Study.
METHODS : Men who resided in the United States , Canada , and Mexico were enrolled from @number@ to @number@
METHODS : Men with prostate cancer , and naïve of hormone treatment , completed the study questionnaires at a single time point.
METHODS : Metalloproteinase- @date@ ( MMP- @date@ ) activity was evaluated by gelatin zymography and gelatinase activity assay kit.
METHODS : Methylation levels were assessed using Illumina 450k arrays on @number@ individuals of European ancestry from @number@ cohort studies.
METHODS : Methylation was measured using Illumina @number@ k arrays in @number@ individuals from six cohorts.
METHODS : Methylglyoxal-induced modification of albumin was tested in a cell-free assay.
METHODS : Mice , human tissues , and cultured corneal cells were studied.
METHODS : Mice with mutations in both HPS1 / pale ear and HPS2 / AP3B1 / pearl ( EPPE mice ) were studied longitudinally.
METHODS : Microarray analysis investigated the association of gene expression in small airway epithelial cells with serum 25 ( OH ) D in adult non-smokers.
METHODS : MicroRNA profiles were analyzed in three pairs of CCA tumor specimens and non-tumorous-paired biliary tissues using Agilent microRNA microarrays.
METHODS : Middle-aged adults and parents ( N = @number@ dyads ) reported the prevalence of parental behaviors attributed to stubbornness.
METHODS : Mid-thigh muscle size and composition were assessed using computed tomography.
METHODS : Minimally stimulated tears were collected from @number@ healthy Chinese adults with no ocular pathology.
METHODS : miRNA microchip assays were performed on HMOX1- and sham-transfected primary rat astroglia and affected miRNAs were further validated by qPCR.
METHODS : Mitochondrial respiration was measured in permeabilised muscle fibres by respirometry.
METHODS : Mitochondrial respiratory capacity and substrate sensitivity were measured in permeabilized muscle fibers by high-resolution respirometry.
METHODS : MMD , defined as the inability to walk @number@ m , was determined over an average follow-up of @number@ years.
METHODS : Modeling was performed using a neurodevelopmental magnetic resonance imaging database of age-specific templates in 6-month increments from @number@ to @number@ years of age.
METHODS : More than @number@ GPs were included in the survey.
METHODS : More than @number@ older persons underwent annual evaluation as part of participation in the Religious Orders Study or Rush Memory Aging Project.
Methods Morning plasma levels of IGF1 , IGFBP3 and IGFBP1 were assayed.
METHODS : Morris , Y , and the elevated plus mazes were used.
METHODS : Mortality data from the National disease surveillance system from @number@ to @number@ was used.
METHODS : Mouse dorsal skin was irradiated with a suberythemal dose of UVB three times a week.
METHODS : MPOD was prospectively measured using autofluorescence spectrometry before and after cataract surgery.
METHOD : SMSQ has been developed on a large and heterogeneous sample ( N = @number@ ) via both , web-based and paper-and-pencil form.
METHODS : MTL anatomical landmarks are identified and registered to create a 3D network.
METHODS : Multisite observational cohort study in @number@ intensive care units at four academic teaching hospitals evaluating @number@ two-year survivors of ALI.
METHODS : Multivariable linear regressions were conducted using a representative sample of German employees born in @number@ and @number@ ( N = @number@ ) .
METHODS : Multivariate analysis of data from @number@ male US Air Force veterans who completed six medical examinations over @number@ years.
METHODS : multivariate statistical analysis using a split sample of data.
METHODS : Myocyte area and collagen volume fraction ( CVF ) were studied in rats.
METHODS : Myoelectric signals from postural muscles and stabilometric data were collected from @number@ non-pregnant and @number@ pregnant women during upright quiet standing.
METHODS : Narrative literature review.
METHODS : National Long Term Care Survey data were used.
METHODS : Nationally-representative , cross-sectional data of the Irish Longitudinal Study on Ageing ( TILDA ) was analyzed.
METHODS : National-multi-centre , cross-sectional study covering PD outpatients.
METHODS : National Online Survey Certification and Reporting data were used to document cumulative nursing facility closures over a decade , @number@ through @number@
Methods : Nationwide , register-based study including all hospitalized patients aged ≥20 years who died from metastatic solid tumors in France between @number@ and @number@
METHODS : Neuropsychological evaluation concerned working memory , episodic memory , processing speed , and executive functions.
METHODS : NHS subjects have medical history and laboratory data collected at 6-month visits.
METHODS : Nighty-seven normal subjects ( @number@ ears ) were recruited for conventional ACS-oVEMP and ACS-cVEMP examinations.
METHODS : Nine children with hemiplegic cerebral palsy ( 3-5 years ) and @number@ age-matched children with typical development participated in the study.
METHODS : nine hundred and seventy-six questionnaires were sent by mail to a sample of healthy and voluntary French pensioners.
METHODS : Nine participants ( @number@ ± @number@ y ) completed the supervised JDE intervention ( once / week for @number@ min ) .
METHODS : Nine patients with unilateral medial knee OA resistant to nonsurgical therapy were treated with the KineSpring System and followed for @number@ years.
METHODS : Nineteen healthy older adults and @number@ young adults performed rapid voluntary stepping under single- and dual-task conditions.
METHODS : Nineteen healthy older adults participated in this study.
METHODS : Ninety-eight elderly users of this clinic were evaluated using cluster analysis and instruments for assessing their overall geriatric status and frailty characteristics.
METHODS : Ninety-eight individuals ( aged 19-71 years ) with good visual acuity , free from ocular disease , and with clear ocular media participated.
METHODS : Ninety-four individuals ( @number@ ± @number@ years ) were included.
METHODS : Ninety-nine patients were randomized to receive epidural , spinal or patient-controlled ( PCA ) analgesia.
METHODS : Ninety-one human donor lenses were irradiated with continuous wave laser light at @number@ @number@ @number@ @number@ @number@ or @number@ nm.
METHODS : Ninety-one patients who received ScoliScore testing at our center and met study inclusion criteria were identified.
METHODS : Ninety-seven FTLD patients were considered in the present study.
METHODS : Ninety-seven non-demented , community-dwelling older adults were randomly assigned to either an expressive suppression group or control group.
METHODS : Ninety subjects were randomized into @number@ different groups , receiving 120-165 U , 166-205 U and 206-250 U , respectively.
METHODS : Nine young adult ( 25±6 years ) and @number@ older participants ( 72±4 years ) took part in the experiment.
METHODS : Nomenclatures as standard tools in information processing are applied.
Methods : Nondemented offspring of the LLFS probands scoring @number@ SD above the mean in a cognitive phenotype were classified as participants with EC.
METHODS : Non-fasting plasma oxytocin was measured from @number@ participants ( 65-90 years ) of the cross sectional KORA-Age study.
METHODS : Nonrandomized comparative case study.
METHODS : Normal Danish subjects ( @number@ ) , of ages 7-17 , and @number@ normal Dutch subjects of ages 5-19 were included.
METHODS : Normal human nucleus pulposus tissues were harvested for culture and identification of NPCs from @number@ patients with burst lumbar vertebra fracture.
METHODS : Normotensive subjects were selected from the PROOF study cohort , including @number@ subjects aged @number@ years at baseline.
METHODS : NPs self-identifying as caring for older adults were interviewed ( N = 15 ) .
METHODS : NSHAP participants with a history of malignancy were included.
METHODS : NT-proBNP concentrations were measured at baseline and at 12-months follow-up in participants of cardiac rehabilitation ( median follow-up @number@ years ) .
METHODS : @number@ adult-onset RA patients whose RA was complicated by biopsy-proven AA amyloidosis were enrolled.
METHODS : @number@ adults 60 + living in Sweden between @number@ and @number@ and participating at the SNAC-K population-based cohort study.
METHODS : @number@ adults aged 30-89 were divided into groups based on their current depression and trauma history.
METHODS : @number@ adults and @number@ children were included in the study.
METHODS : @number@ adults of the French Epidemiological Study on the Genetics and Environment of Asthma ( EGEA ) were studied.
METHODS : @number@ Albertans aged @number@ years and older participating in an organized ' Games ' received a research package.
METHODS : @number@ asymptomatic subjects who visited our hospital for a routine health check-up were enrolled.
METHODS : @number@ behavioral variant FTD and @number@ agrammatic variants of primary progressive aphasia patients were included.
METHODS : @number@ blood samples were aged under controlled conditions and the impact on the \ "Aged sample \ " software was checked retrospectively.
METHODS : @number@ CF patients were interviewed.
METHODS : @number@ child or adolescent family members of individuals with schizophrenia were interviewed using the Scale of Prodromal Symptoms and the Tanner Maturational Scale.
METHODS : @number@ CN elderly participants underwent clinical examination , a range of neuropsychological tests , APOE genotyping , and Pittsburgh compound-B- and fluorodeoxyglucose-PET scans.
METHODS : @number@ cognitively healthy elderly subjects living in the community , from the Kungsholmen Project.
METHODS : @number@ community-dwelling elderly who had been enrolled in the Shihpai eye study ( 1999-2000 ) were included.
METHODS : @number@ Consecutive patients with BAVMs between @number@ and @number@ were retrospectively reviewed.
METHODS : @number@ CTC studies performed between @date@ and @date@ were analysed retrospectively.
METHODS : @number@ CT scans were studied.
METHODS : @number@ DLB and @number@ AD patients , and @number@ healthy elderly participants were studied.
METHODS : @number@ elderly patients with type 2DM , were enrolled in this prospective and observational study.
METHODS : @number@ ET cases were enrolled in a clinical-epidemiological study at Columbia University.
METHODS : @number@ geriatric diabetic patients ( male / female : 69 / 85 ) were enrolled in this study.
METHODS : @number@ healthy men aged between @number@ and @number@ years were tested.
METHODS : @number@ healthy schoolchildren aged @date@ years from @number@ Badia hamlets were nutritionally investigated by applying anthropometric , laboratory and dietary assessment methods.
METHODS : @number@ healthy subjects aged 25-70 years were examined at @number@ TMR.
METHODS : @number@ healthy subjects ( @number@ male and @number@ female ) were included in this study.
METHODS : @number@ hypertensive patients recruited in the seventies had an aortic ATS score at pretreatment aortography.
METHODS : @number@ individuals > @number@ years were examined and genotyped.
METHODS : @number@ inpatients , aged over @number@ years , were recruited at the Department of General Internal Medicine at a tertiary university hospital.
METHODS : @number@ Korean adults aged between @number@ and @number@ years-old participated in the study.
METHODS : @number@ MCI underwent FBB positron emission tomography , MRI and neuropsychological assessment at baseline and @number@ years and clinical follow-up at @number@ years.
METHODS : @number@ men and @number@ women aged @number@ to 96years , residents in the Reykjavik area , were included in this cross-sectional study.
METHODS : @number@ men and women aged @number@ to @number@ were selected.
METHODS : @number@ men and women from the Uppsala Birth Cohort Multigenerational Study were followed for @number@ years.
Methods : @number@ monozygotic and dizygotic Finnish twin sisters ( age @number@.4±3.4 years ) were included.
METHODS : @number@ narrative in-depth interviews with multimorbid patients were conducted.
METHODS : @number@ NHS hospitals were analysed by data envelopment analysis for overall , technical and scale efficiency , and Malmquist index.
METHODS : @number@ non-demented individuals were recruited from the European population-based DESCRIPA study.
METHODS : @number@ non-diabetic older patients , mean age @number@ ± @number@ years , were included in this observational study.
METHODS : @number@ non-surgical patients aged ≥ @number@ years were consecutively enrolled upon admission to the ED.
METHODS : @number@ obese older adults were subjected to @number@ wk weight loss program , including hypocaloric diet and resistance training.
METHODS : @number@ older ( 60±2 years ) and @number@ younger men ( 23±3 years ) underwent bed rest ( BR ) for @number@ days.
METHODS : @number@ older adults with cognitive impairment were enrolled in this study.
METHODS : @number@ out of @number@ patients participating in a previous multicenter clinical-MRI study were enrolled ( @percent@ were lost at follow-up ) .
METHODS : @number@ participants ( @percent@ women ; mean age 63±7.5 years ) were prospectively followed for @number@ years.
METHODS : @number@ patients over the age of @number@ were enrolled in @number@ year time for a multicentre retrospective observational study.
METHODS : @number@ patients underwent EC-IC standard bypass surgery with translocation of the superficial temporal artery to an M2 segment of the medial cerebral artery.
METHODS : @number@ patients with MSA , @number@ patients with iRBD , @number@ patients with PD , and @number@ healthy controls completed the study.
METHODS : @number@ PD patients and @number@ age-matched controls , > 65 years were studied.
METHODS : @number@ PD subjects , not demented at baseline , were studied from the Arizona Study of Aging and Neurodegenerative Disorders cohort.
METHODS : @number@ ( @percent@ ) subjects were included in the study , for whom BBS , and static and dynamic balance measurements were performed.
METHODS : @number@ persons with type @number@ diabetes ( mean age @number@ ± @number@ years ) were studied.
METHODS : @number@ Polish and @number@ German subjects aged from @number@ to @number@ years were classified into @number@ age groups.
METHODS : @number@ postmenopausal women with urogenital aging symptoms were enrolled in this prospective randomized study.
METHODS : @number@ residents from nursing homes in Sweden , Norway and Denmark were included.
METHODS : @number@ senior female residents of L.A. Helc Nursing Home in Cracow , Poland , were examined.
METHODS : @number@ senior persons participated in the research : @number@ with very mild AD , @number@ with aMCI , and @number@ control group.
METHODS : @number@ Spanish elders aged ≥65 years underwent a neuropsychological evaluation in order to measure executive function.
METHODS : @number@ subjects from community centers were included in this analysis.
METHODS : @number@ subjects from the Alzheimer's Disease Neuroimaging Initiative ( ADNI ) .
METHODS : @number@ subjects referred by their general practitioner to a geriatric frailty clinic were assessed between @date@ and @date@ .
METHODS : @number@ subjects were enrolled ( including @number@ Parkinsonism and @number@ arthritis ) from Ulaanbaatar and @number@ other areas in Mongolia.
METHODS : @number@ untrained subjects ( @number@ ± @number@ years ) first completed a 1-RM direct assessment with a horizontal leg press pre- and post-training.
METHODS : @number@ veterans age @number@ and older from @number@ HBPC programs from across the country participated in the study.
METHODS : @number@ women ( @number@ in the fibromyalgia group and @number@ in the elderly group ) volunteered to participate in the study.
METHODS : @number@ young and @number@ older adults underwent unilateral visuomotor tracking ( VT ) , with anodal or sham-tDCS over the ipsilateral motor cortex.
METHODS : @number@ young and @number@ postmenopausal women participated.
METHODS : @number@ young subjects , @number@ healthy old subjects , and @number@ Parkinson's disease ( PD ) patients took part in this study.
METHODS : Nursing home residents admitted to the hospital with acute respiratory illness were enrolled in the study.
METHODS : Nursing homes in Sweden , Norway and Denmark were involved , and @number@ residents were randomized to either Intervention or Control groups.
METHODS : Objective and subjective assessment of memory function was carried out in @number@ elderly adults.
METHODS : Observational case series.
METHODS : Observational study ( N = 1072 ) aged ≥ @number@ years old , recruited by general practitioners.
METHODS : Observational study of @number@ community-dwelling adults ages 65 + responding to the @number@ National Health and Aging Trends Study.
METHODS : Observational study performed on hospitalized patients aged @number@ years or more.
METHODS : Odor identification performance and valence interaction was evaluated among @number@ schizophrenic patients and @number@ controls.
Methods of estimation and inference about survival distributions based on length-biased samples are well-established.
Methods of measurement were left to the individual laboratories. pH was measured on both laboratory pH meters and clinical blood gas machines.
METHODS : Of @number@ living donor liver transplants , ten pairs were adult-to-pediatric combinations.
METHODS : Of @number@ men at baseline , @number@ were followed up @number@ years later.
Methods of reducing the effect of retinal and choroidal vessels are also described.
METHODS : Of the @number@ individuals recruited , @number@ completed the questionnaires , resulting in a response rate of @percent@.
METHODS : Of the @number@ studies reviewed , @number@ provided alpha coefficients which were then used in the meta-analyses of internal consistency.
Methods of this specific longitudinal study are presented to provide background to the discussion.
Methods of warming patients may vary from inexpensive to expensive in cost and simple to complex in nature.
Methods : Older adults with severe aortic stenosis presenting for surgery were assessed for frailty using Cardiovascular Health Study Criteria.
METHODS : Older people underwent a cognitive tests battery and a nocturnal polygraphy recording.
METHODS : Older women ( n = @number@ ) were recruited from the local community.
METHODS : Older women with invasive , non-metastatic breast cancer ( n = 150 RCT ; @number@ off-trial ) were included.
METHODS : Oligomycin was injected into the rat left knee joint on days @number@ @number@ and @number@ before joint tissues were obtained on day @number@
METHODS : One dermatologist examined @number@ seafarers and documented the presence of @number@ extrinsic skin ageing symptoms.
METHODS : One hundred and eighty adults without exercise habit were included in this cross-sectional study.
METHODS : One-hundred and eighty participants ( range 18-87 years ) were assessed with eight FDM tests and several standard neuropsychological tests.
METHODS : One hundred and fifty-eight female participants of the Longitudinal Assessment of Ageing in Women study , aged 48-85 years , were evaluated.
METHODS : One hundred and fifty-six volunteers from Hanghzou areas were enrolled in the study.
METHODS : One hundred and five healthy subjects had median motor nerve excitability testing performed at the wrist using the automated threshold-tracking program , QTRAC.
METHODS : One hundred and forty-eight women ( one knee for each subject ) aged ≥40 years were included.
METHODS : One hundred and forty-five sporadic age-related cataract patients and one hundred and fifty-six unrelated random healthy controls participated in this study.
METHODS : One hundred and forty-four bronchiectasis patients and eighty healthy subjects were enrolled.
METHODS : One hundred and ninety-five T2DM patients received a CRT-d treatment.
METHODS : One hundred and ten individuals at risk for diabetes participated in this study.
METHODS : One hundred and twelve patients with MCI , @number@ patients with AD , and @number@ healthy elderly adults participated in this study.
METHODS : One-hundred-fifteen participants free of hydrocephalus from the GAIT study ( mean , @number@.4±4.4years ; @percent@ female ) were included in this analysis.
METHODS : One hundred fifty-five cadaveric donor transplantations performed at our center between @number@ and @number@ were selected for the study.
METHODS : One hundred fifty-two healthy subjects between the ages of @number@ and @number@ years were included in this cross-sectional study.
METHODS : One hundred fifty-two postmenopausal women participated in a smoking cessation study using the nicotine patch.
METHODS : One hundred forty CNAs completed semistructured , in-person interviews concerning their experiences regarding resident death.
METHODS : One hundred forty-five healthy volunteers participated in the study.
METHODS : One hundred forty-one eyes from @number@ donors ( mean age ± standard deviation , @number@ ± @number@ ) were studied.
METHODS : one hundred patients aged ≥60 with chronic OH were randomised into SHU or control groups.
METHODS : One hundred patients diagnosed with MCI and @number@ control subjects were recruited from the community-dwelling setting in Bangkok , Thailand.
METHODS : One hundred PD patients ( with mean age of @number@ ± @time@ years ) were included.
METHODS : One-hundred post-stroke patients with confluent WMC were recruited into the study.
METHODS : One hundred seventy-four subjects ( @number@ female and @number@ male ) were admitted to the long-term-care ANASTE Calabria study.
METHODS : One hundred subjects aged 65-84 years participated in the study.
METHODS : One hundred symptom-free females , who had no radiographic evidence of osteoarthritis , were evaluated using MFM with 15-marker set.
METHODS : One hundred thirty-six healthy elderly from the Berkeley Aging Cohort Study were followed up for a mean of @number@ years.
METHODS : One hundred three young adult participants ( @number@ males , @number@ females ) were tertiled into adolescent LTM accrual groupings.
METHODS : One hundred twenty healthy volunteers were involved in this study.
METHODS : One hundred twenty MS cases ( @number@ tissue blocks ) were included.
METHODS : One hundred twenty-six healthy individuals who were recruited as part of a larger study on swallowing participated in this study.
METHODS : One hundred twenty-two women with stress urinary incontinence and mixed urinary incontinence were included in this prospective controlled study.
Methods One hundred two older adults with ( n = @number@ ) and without ( n = @number@ ) chronic LBP were included.
METHODS : On entry into permanent residential aged care , people's care needs are assessed on the Aged Care Funding Instrument ( ACFI ) .
METHODS : One thousand eight hundred seventy-five participants seeking biennial health checkup were enrolled from a nationwide distribution of randomly selected registry of primary clinics.
METHODS : One thousand one hundred sixty-six stroke-free participants from the NOMAS ( Northern Manhattan Study ) underwent carotid ultrasound and neuropsychological examination.
METHODS : One thousand three hundred ninety-five subjects without dementia age @number@ and older participated in this study.
METHODS : One-year longitudinal study of older adults with diagnosed osteoarthritis of the knee.
METHODS : On @number@ Thyroidectomy performed , we selected @number@ cases of follicular neoplasms ( @number@ females and @number@ males ) .
METHODS : Oocytes from @number@ ICSI cycles were analysed with polarized microscopy.
METHODS : Operational definitions of the ARWMC scale were derived from Erkinjuntti research criteria for subcortical vascular dementia and Scheltens scale.
METHODS : Oral glucose tolerance test was performed in a total of @number@ Chinese without diabetes history.
METHODS : Osteoarthritic chondrocytes were co-cultured with an increasing concentration of PRP obtained from healthy donors.
METHODS : Our cross-sectional analysis included @number@ men and nonpregnant women aged 20 + years from the 1999-2010 National Health and Nutrition Examination Survey.
METHODS : Our hospital is a tertiary academic medical center with 24-h in-house resident coverage.
METHODS : Our population is represented by a cohort of @number@ patients undergoing coronary angiography.
METHODS : Our prospective cohort study used surveillance , epidemiology , and end results linked to the Medicare Health Outcomes Survey.
METHODS : Our sample included @number@ orthodontic patients from whom we had access to annual lateral cephalometric radiographs and IGF-1 measurements.
METHODS : Our study included @number@ individuals born in Norway 1940-1950.
METHODS : Our study included @number@ patients with BPH , @number@ ( @percent@ ) of whom had MetS.
METHODS : Our study used the SOMAscan platform for protein quantification in blood serum.
METHODS : Outcome examined was incident activity of daily living ( ADL ) disability assessed annually ( @number@ measures were performed ) .
METHODS : Out of @number@ adults with DS who originally participated in a longitudinal study , @number@ were followed up at @number@ years.
METHODS : Out of @number@ male patients aged @number@ years and above diagnosed with BPE , @number@ were included in the study.
METHODS : Ovariectomized nude mice were transplanted with MCF-7 breast cancer cells constitutively expressing aromatase.
METHODS : Over a 24-month period , @number@ patients underwent EUS for an indication unrelated to pancreaticobiliary disease.
METHODS : Over @number@ adults across a wide-age range performed different versions of cognitive tests on several sessions at each measurement occasion.
METHODS : Over @number@ articles related to cochlear implants , cognition , and older adults were reviewed.
METHODS : Over the course of @number@ years , @number@ faces of living female Caucasian patients were prospectively studied using high-resolution magnetic resonance imaging.
METHODS : Overweight or obese adults with type @number@ diabetes mellitus ( n = @number@ ) were randomly assigned to either ILI or DSE.
METHODS : Overweight status of @number@ @number@ French children aged 7-9 years in @number@ was estimated , using measured weight and height data collected retrospectively.
METHODS : Panel data were obtained from the Nihon University Japanese Longitudinal Study of Aging database.
METHODS : Parameters of PI , S1W , and PTH were evaluated from computed tomography images of the subjects.
METHODS : Participant- and assessor-blinded , randomized clinical trial involving participants with moderate to severe nasolabial folds.
METHODS : Participants > 65 years were recruited to a cross-sectional study.
METHODS : Participants aged 70-89 years at enrollment were clinically evaluated at baseline and 15-month intervals to assess diagnoses of MCI and dementia.
METHODS : Participants aged @number@ years or older without clinical dementia or major psychiatric disorders were recruited.
METHODS : Participants are Japanese-American men from the Honolulu Asia Aging Study.
METHODS : Participants came from the Rush Memory and Aging Project.
METHODS : participants come from MRC CFAS , a multi-centre longitudinal population-based study of ageing in England and Wales.
METHODS : Participants completed exercise testing to evaluate CRF ( peak VO2 ) and neuropsychological testing to assess cognition.
METHODS : Participants comprised @number@ healthy adults aged @number@ to @number@ years.
METHODS : Participants consisted of community-dwelling older adults from the Duke Established Populations for Epidemiologic Studies of the Elderly ( EPESE ) .
METHODS : Participants consisted of community-dwelling older adults from the Duke Established Populations for Epidemiologic Studies of the Elderly ( N = @number@ ) .
METHODS : Participants from an HIV-infected cohort ( n = @number@ ) completed pulmonary function testing ( PFT ) .
METHODS : Participants from @number@ to @number@ years old watched a video that simultaneously showed a positive and a negative image.
METHODS : Participants ' homes were assessed using the Home Environment Assessment for the Visually Impaired ( HEAVI ) .
METHODS : Participants included @number@ black and white adults ( @percent@ black , @percent@ women ) from the Chicago Health and Aging Project.
METHODS : Participants included @number@ community-dwelling people aged @number@ years or older who resided in the four major cities of the Hebei province.
METHODS : Participants included @number@ dyads of parents ( aged 59-96 years ) and their children ( aged 40-60 years ) .
METHODS : Participants included @number@ HIV-1 infected younger ( aged 20-40 ) and @number@ HIV-1 older patients ( aged 50-75 ) .
METHODS : Participants included @number@ un-medicated MDD subjects and @number@ HC for assay of LTL , 12-hour overnight urinary free cortisol and catecholamine levels.
METHODS : Participants included @number@ Y-O and @number@ O-O adults.
METHODS : Participants in the Aging , Demographic , and Memory Study ( ADAMS ) were evaluated for cognitive impairment using a comprehensive in-home assessment.
METHODS : Participants in the Baltimore Longitudinal Study of Aging underwent cervical and ocular VEMP testing.
METHODS : Participants in this case series were four patients with nAMD , who received anti-VEGF injections with variable therapeutic response to treatment.
METHODS : Participants ( n = @number@ ) enrolled in a longitudinal study of memory and aging underwent 3-T fcMRI.
METHODS : Participants ( N = @number@ ) were recruited from two mental health courts in the midwestern United States.
METHODS : Participants ( @number@ men , @number@ women aged 70-92 ) completed a fast- and usual-paced 400-m walk.
METHODS : Participants of the Irish longitudinal study on ageing ( TILDA ) were studied.
METHODS : Participants performed repeated pairs of key-presses on a piano-type keyboard as well as key-presses that conflicted with that prepotent pair.
METHODS : Participants received clinical evaluations including physical measurements , demographic and lifestyle questionnaires , physical and neurologic examinations , and neuropsychological testing.
METHODS : participants reported regular medication use at baseline.
METHODS : Participants were adults with cancer treated with curative intent.
METHODS : Participants were assessed during the most recent cross-sectional data collection of the Georgia Centenarian Study.
METHODS : Participants were a subsample of older adults ( > = @number@ years ) from the Einstein Aging Study.
METHODS : participants were classified into five risk groups at hospital admission using the ISAR-HP.
METHODS : Participants were community-dwelling elderly individuals ( n = @number@ ) .
METHODS : Participants were consecutively recruited from an outpatient population.
METHODS : Participants were enrolled in the Leiden Longevity Study.
METHODS : Participants were evaluated at baseline and @number@ years later.
METHODS : Participants were from the population-based Framingham Foot Study.
METHODS : Participants were men from the Vietnam Era Twin Study of Aging ( n = @number@ ) .
METHODS : Participants were middle aged adults who resided in the community in three cities in Korea.
Methods : Participants were @number@ adults aged ≥60 years from the China Health and Retirement Longitudinal Study.
METHODS : Participants were @number@ adults independent in self-care activities from a representative sample of older Medicare beneficiaries.
METHODS : Participants were @number@ bariatric surgery patients who completed cognitive testing before surgery and @number@ year postsurgery.
METHODS : Participants were @number@ Finnish men and women born between @number@ and @number@ who participated in the Helsinki Birth Cohort Study.
METHODS : Participants were @number@ individuals aged @number@ to @number@ years from the Three-City Dijon Study.
METHODS : Participants were @number@ Israeli adults with memory complaints , aged @number@ years or older.
METHODS : Participants were @number@ Japanese women ( mean age = @number@ years ) .
METHODS : Participants were @number@ male medical students without a diagnosis of depression , who matriculated in 1948-1964 and followed through @number@
METHODS : Participants were @number@ men and women ( aged @number@.3±7.7 years , @percent@ men ) from the English Longitudinal Study of Ageing.
METHODS : Participants were @number@ men and women ( mean age @number@ ± @number@ years ) from the English Longitudinal Study of Ageing.
METHODS : Participants were @number@ nondemented older adults ( mean age @number@ years ; @percent@ women ) enrolled in a community-based cohort study.
METHODS : Participants were @number@ older African Americans ( 60-98 years old ) enrolled in the Minority Aging Research Study.
METHODS : Participants were @number@ older people without cognitive impairment at study onset.
METHODS : participants were @number@ people aged @number@ and over from the English Longitudinal Study of Ageing.
METHODS : Participants were @number@ ( @percent@ black and @percent@ female ) older adults from the Health , Aging , and Body Composition Study.
METHODS : Participants were @number@ ( @percent@ from total ) residents aged ≥ @number@ years in Bambuí City , Brazil.
METHODS : Participants were part of the prospective observational University of Alabama at Birmingham Study of Aging ( n = @number@ ) .
METHODS : Participants were randomized to either a PA or health education ( HE ) program.
METHODS : Participants were randomized to receive a lung age-based motivational strategy ( intervention group ) versus standard care ( control group ) .
METHODS : Participants were randomly chosen from the population-based Hallym Aging Study , irrespective of whether they had knee osteoarthritis ( OA ) or pain.
METHODS : Participants were randomly recruited from electoral rolls after stratification on sex , 10-year age group ( 35-74 years ) and town size.
METHODS : Participants were recruited from three geographical locations in the West of Scotland.
METHODS : Participants were recruited in the Netherlands through newsletters and social media to participate in a web-based questionnaire.
METHODS : Participants were registered in Florida's comprehensive inpatient surveillance system for the years 2006-2007 with principal diagnosis of STEMI.
METHODS : Participants were sampled based on maternal alcohol consumption before pregnancy.
METHODS : Participants were screened for cardiovascular disease risk using two multifactorial risk models : the Systematic Coronary Risk Evaluation and the Framingham Risk Equation.
METHODS : Participants were tested in a no-gap , no-overlap saccadic task using a video-based remote eye tracker.
METHODS : Participants were workers aged 50 + enrolled in the Health and Retirement Study , @number@ to @number@
METHODS : Patient Activation levels were derived by taking the weighted average responses to the Patient Activation Supplement.
METHODS : Patient records were retrospectively reviewed from @date@ through @date@ .
METHODS : Patients ≥60 years of age admitted with a fall to a tertiary referral teaching hospital in Sydney were recruited and frailty was assessed.
METHODS : patients ≥60 years old admitted to the medical ICU were enrolled in a prospective parent cohort studying delirium.
Methods : Patients aged @number@ or older enrolled in internal medicine and geriatric wards participating in the REPOSI registry.
METHODS : Patients commencing dialysis in our centre between @number@ and @number@ were identified.
METHODS : Patients completed the SF-36 QoL questionnaire , 400-m walk , 5-time chair rise , and grip strength.
METHODS : Patients evaluated at Movement Disorders Clinic Saskatchewan are offered a choice of autopsy at no cost.
METHODS : Patients examined after @number@ years in the intervention study Swedish Obese Subjects were used for the current analysis.
METHODS : Patients from both subgroups received surgical indication according to the same criteria.
METHODS : Patients from our hospital aged ≥ @number@ years with lung cancer completed a questionnaire form prior to chemotherapy.
METHODS : Patients greater than @number@ years of age undergoing ACLR between @date@ and @date@ were identified.
METHODS : Patients had lens extraction and implantation of an Acrysof Natural tinted or Tecnis ZA9003 or Softec III untinted acrylic IOL.
METHODS : Patients investigated for suspected interstitial lung disease were prospectively enrolled.
METHODS : Patients less than @number@ years of age , undergoing surgery , requiring endotracheal intubation with a cuffed ETT were eligible for inclusion.
METHODS : Patients @number@ years and older admitted to a geriatrics outpatient clinic between @date@ and @date@ were included.
METHODS Patients older than @number@ years undergoing thoracolumbar spine surgery from @number@ to @number@ were retrospectively analyzed.
METHODS : Patients scheduled for elective moderate risk surgery under general anaesthesia were enrolled.
METHODS : Patients treated at our Intensive Care Unit for acute respiratory failure following thyroid surgery from @date@ to @date@ , were reviewed.
METHODS : Patients using prostaglandin analogue drops in only @number@ eye for at least @number@ year were evaluated by masked examiners.
METHODS : Patients were divided into @number@ groups ( NOP and OP ) .
METHODS : Patients were identified from a tertiary center database that included all patients with UGIB.
METHODS : Patients were included at diagnosis with MMSE score between @number@ and @number@ and were naive of symptomatic treatment for AD.
METHODS : Patients were injected with abobotulinumtoxinA along the inferior border of the mandible and into the platysmal bands.
METHODS : Patients were @number@ years and older and admitted for surgical repair of an acute hip fracture.
METHODS : Patients were participants in the maintenance phase of the DURABLE trial.
METHODS : Patients were randomized for the side of the forehead ( left or right ) in which the products were administered.
METHODS : Patients were sampled from population-based cancer registries in Germany.
METHODS : Patients who underwent SBRT were reviewed from @number@ to @number@ at @number@ academic centers.
METHODS : Patients with a history of migraine as defined by the @number@ Ad Hoc Committee report were recruited for this study.
METHODS : Patients with ARC , and age- , sex- and ethnically-matched healthy control subjects were enrolled in the study.
METHODS : Patients with both stable coronary heart disease and acute coronary syndromes undergoing PCI were included in the study.
METHODS : Patients with BPH on medical therapy of least @number@ months and up to @number@ months were interviewed.
METHODS : Patients with IBD from a Dutch multicenter cohort filled out 3-monthly questionnaires for @number@ years.
METHODS : Patients with moderate-to-severe OSA were enrolled.
METHODS : Patients with nuclear or cortical age-related cataract were recruited.
METHODS : Patients with primary osteoporosis diagnosed using DEXA were evaluated in this cross-sectional analysis.
METHODS : Patients with recalcitrant low back pain underwent diagnostic procedures based on their clinical presentation until the pain source was identified.
METHODS : Patients with RP as well as age- and sex-matched controls underwent external cold provocation by exposure to @number@ °C water for @number@ minute.
METHODS : Patients with varying severity of AMD and diabetes and normal subjects of similar age were recruited for the study.
METHODS : PA was assessed for @number@ days using the Actigraph GT3X + accelerometer in @number@ older adults ( @number@ females ) aged 70-77 years.
METHODS : PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database ( STN-DBS = @number@ non-DBS = @number@ ) .
METHODS : People with widened pores were recruited , with photographs taken on their nasal tips , nasal alas and cheeks.
METHODS : Peripheral blood mononuclear cells ( PBMCs ) were obtained from BD patients with active ileocecal ulcers or from healthy donors.
METHODS : Peripheral neuropathy was defined as at least mild loss of vibration sensation in both great toes or absent / hypoactive ankle reflexes bilaterally.
METHODS : Personality was measured by the NEO Personality Inventory-Revised , and self-rated health was assessed by the Health Problems Checklist.
METHODS : Pertinent studies were identified by searching in PubMed and in Webscience.
METHODS : Pertinent studies were identified by searching PubMed and EMBASE databases up to @date@ .
METHODS : PEs were developed in a cohort of @number@ healthy subjects and then validated in a convenience cohort of @number@ healthy subjects.
METHODS : PhA was derived from whole body impedance analysis.
METHODS : Phenomenological approach.
METHODS : Photoaging was explored in women who were both sunshine and sunbed worshippers.
METHODS : Physical fitness was evaluated by @number@ adapted tests from \ "Senior Fitness Test \ " and \ "Eurofit Testing Battery \ ".
METHODS : physical limitations were defined as < 75% of optimal physical functioning using the Physical Functioning ( PF-10 ) Subscale of the Short-Form-36 questionnaire.
METHODS : Physical performance speed on gait and mobility tasks was measured via usual gait speed and the TUG ( at fast pace ) .
METHODS : plasma activities of AChE and BuChE were measured pre- and postoperatively in consecutive patients ≥60 years old undergoing elective total hip replacement surgery.
METHODS : Plasma concentrations of sST2 ( ELISA , Critical Diagnostics ) were measured at baseline in a cohort of @number@ patients.
METHODS : plasma cystatin C and plasma creatinine were used as markers for GFR.
METHODS : Plasma neopterin levels were determined in @number@ Old Order Amish adults.
METHODS : Population-based cohort study of @number@ community-dwelling participants , aged ≥60 years , from the Longitudinal Aging Study Amsterdam ( LASA ) .
METHODS : Population-based data consisted of @number@ men ( aged 42-60 years ) from Eastern Finland.
METHODS : Postal follow-up in 2007 / 8 of a national random sample of @number@ people aged @number@ and over in 1999 / 2000.
METHODS : Post-marketing surveillance data from @number@ patients treated with CZP were analyzed.
METHODS : Postmenopausal women ( n = @number@ ) not using menopausal hormone therapy and presenting with or without symptoms of vulvovaginal irritation were screened.
METHOD : Spouses of individuals with musculoskeletal pain were recorded describing their partners ' suffering while their blood pressure ( BP ) was monitored.
METHODS : Pre- and post-CT scans of the pelvis in @number@ men aged 49-78 years receiving leuprorelin were examined.
METHODS : Preliminary stability tests were carried out and an in vivo study was performed with three groups with @number@ representatives each.
METHODS : Prequit-day data were taken from the control arm of an ongoing randomized controlled trial of a smoking-cessation program.
METHODS : Present prospective randomized study.
METHODS : Preterm infants administered aminophylline or theophylline to treat apnoea of prematurity were enrolled in this study.
METHODS : Previously , we reported the total synthesis of ( + ) -isonitramine , one of Nitraria alkaloids.
METHODS : Primary literature search on PubMed for GA , complement cascade in age-related macular degeneration.
METHODS : Primary porcine coronary ECs were isolated from the left circumflex coronary artery.
METHODS : Primary research publications about emergency nurses ' attitudes towards and knowledge about older people were sought in six databases and Google.
METHODS : Projections were based on cancer incidence data estimated from cancer registries for the 1989-2009 periods and demographic projections of the Federal Statistical Office.
METHODS : Pros-IT CNR is an observational , prospective , multicenter study.
METHODS : Prospective cohort study.
METHODS : Prospective cohort study.
METHODS : Prospective counseling and germline testing of consecutive patients with primary diagnosis or with platinum-sensitive relapse of an invasive epithelial ovarian cancer.
METHODS : Prospective data were from the English Longitudinal Study of Aging , a nationally representative sample of English adults over the age of @number@
METHODS : Prospective , multicentre , cohort study of patients aged @number@ years and older.
METHODS : Prospective observational study in @number@ post-menopausal women and men entering 18-month treatment with teriparatide in a community setting at @number@ centres in Italy.
METHODS : Prospective observational study of @number@ individuals from the Health , Aging , and Body Composition study.
METHODS : Prospective population based cohort study during the years 2003-2011.
METHODS : Prospective study involving @number@ hypertensive , community-dwelling older women with different metabolic disorders.
METHODS : Prospective study of apparently healthy individuals aged ≥60 years of age.
METHODS : Prospective study of @number@ uncomplicated pregnancies delivering at term.
METHODS : Protective stepping responses were elicited by a platform moving unpredictably either forwards or backwards.
METHODS : PSL and full-kinetics of PSU were determined on @number@ blood donors ( @number@ males , @number@ females ; 20-67 years ) .
METHODS : PS-omega-3 was administered daily for @number@ weeks to eight elderly volunteers with subjective memory complaints.
METHODS : Psychiatry clerkship directors at @number@ American medical schools were surveyed about didactic and clinical experiences of geriatric psychiatry.
METHODS : Psychometric analyses were conducted on @number@ self-reported dichotomous symptom indicators collected during in-person interviews from a sample of @number@ community-dwelling older adults.
METHODS : Psychometric evaluation of the instrument was completed in two phases.
METHODS : Publications relevant to peanut allergy were searched via Pubmed , and prevalence and etiological factors of peanut allergy were reviewed.
METHODS : Public data , official documents , literature , and news releases were surveyed and discussed.
METHODS : PubMed and Healthstar databases were searched.
METHODS : PubMed and Scopus were searched for observational studies that investigated the association between sarcopenia and cognitive dysfunction.
METHODS : PubMed , Cochrane Database of Systematic Reviews , EMBASE , and CINHAL ( from inception to @date@ ) were searched.
METHODS : PubMed was searched for articles published in @number@ and only RCTs were included.
METHODS : QSM was performed retrospectively by using phase images from resting state functional magnetic resonance imaging ( fMRI ) .
METHODS : Qualitative analysis of semi-structured focus groups with quantitative analysis of clinical administrative data.
METHODS : Qualitative analysis using survey data from staff working in @number@ Indiana nursing homes.
METHODS : Qualitative interviews were conducted with ten experts from different areas across Australia.
METHODS : Quantitative interviews were conducted among @number@ isiXhosa speaking caregivers of @number@ years and older in the Eastern Cape of South Africa.
METHODS : Quantitative rCBF was assessed in @number@ adolescents ( age 12-15 ) .
METHODS : Questionnaire data and blood samples were collected from @number@ participants ( ≥18 years old ) from the general population.
METHODS : Questionnaire data were collected from @number@ participants in four Chinese cities in @number@
METHODS : Questionnaire measures of depression , hopelessness , general health and resilience were administered to the participants.
METHODS : Racial differences in self-reported surgical and nonsurgical overnight hospital admissions were examined using Cox proportional hazards models.
METHODS : Randomized , comparative , evaluator-blinded , single-center study.
METHODS : Randomized , multicentre clinical trial with @number@ parallel groups.
METHODS : Randomly selected ambulatory patients with cancer participated in this study.
METHODS : RAW264.7 , HEK293 and BHK-21 cells were used for in vitro studies.
METHODS : Raw data were downloaded from Gene Expression Omnibus database.
METHODS : Recent developments in miniaturized ultrasound arrays have provided us with high-quality 3D echocardiographic data.
METHODS : Recruitment was performed between @date@ and @date@ .
Methods refinements in Wave @number@ improved the detection of BV and Candida and clarified their relationship with age.
METHODS : Registry-based study using merged data from the National Population Register and the Norwegian Health Economics Administration database.
METHODS : Relationships between body fat changes and change in Short Form-36 Physical and Mental Component Summary scores were investigated using mixed-model regression.
METHODS : Relative and absolute concentrations of @number@ circulating PLFAs were measured by gas chromatography in samples from @number@ diverse populations.
Methods Relevant studies on DI prevalence in this population were reviewed in PubMed , Cochrane Library and EMBASE ( @date@ - @date@ ) .
METHODS : Relevant studies were identified by searches in electronic reference databases and selected by two reviewers independently.
METHODS : Remelted and annealed HXLPE prisms ( n = @number@ per test condition ) were tested in a wear simulator for @number@ cycles.
METHODS : Replicas of the crow's feet area of volunteers were recorded in @number@ and @number@ and observed comparatively.
METHODS : Report-AGE study is a large observational study on health conditions and outcomes of hospitalized elderly patients ( ≥65 years ) .
METHODS : Research data were obtained from the 2000-2010 Taiwan National Health Insurance Research Database.
METHODS : Research was performed to compare differences in surface alterations between not-aged ( NA ) samples and accelerated-aging ( AA ) samples.
METHODS : residents completed the measures in interviews.
METHODS : Residents of a German residential facility for people with ID were asked to take part.
METHODS : Residents of randomly selected houses and clusters participated in the survey.
METHODS : Respondents ( N = 283 ) completed eHEALS as part of a cross-sectional landline telephone survey.
METHODS : Results are based on HRQoL ratings made on a 5-point Likert scale by @number@ community-based elder-proxy dyads on three occasions.
METHODS-RESULTS : The development of locking plates has allowed complication avoidance.
METHODS & RESULTS : Young ( n = 42 ) and aging ( n = 49 ) subjects underwent evaluation of platelet TXNIP content.
METHODS : Retinal photography and interview with comprehensive questionnaires were conducted at each visit of three studies.
Methods : Retinas were obtained from @number@ nondiabetic donors.
Methods : Retinas were obtained from @number@ nondiabetic donors and from mice deficient in Bmi1.
METHODS : Retrospective analysis in a series of @number@ patients including @number@ elderly individuals at a single institution was carried out.
METHODS : Retrospective analysis of a large recent and monocentric database of LR was performed between @date@ and @date@ .
METHODS : Retrospective analysis of medical records was conducted at a university hospital.
METHODS : Retrospective analysis of @number@ patients with audiogram follow-up.
METHODS : Retrospective analysis of @number@ stimulated IVF / ICSI cycles in a hospital-based IVF centre was performed from @date@ to @date@ .
METHODS : Retrospective case review of @number@ octogenarian admissions to a regional neurosurgical unit from January to @date@ .
METHODS : Retrospective chart review.
METHODS : Retrospective chart review.
METHODS : Retrospective cohort study of @number@ paediatric patients being followed for PCNST in a single referral oncological centre.
METHODS : Retrospective cohort study of @number@ patients admitted to @number@ U.S. ICUs from @number@ to @number@
METHODS : Retrospective , observational study.
METHODS : Retrospective review of patients treated with endovascular methods for iliac artery occlusive disease between @date@ and @date@ at VA Connecticut Healthcare System.
METHODS : Retrospective study of elderly patients ( ≥ @number@ years of age ) with a clinical diagnosis of SCI.
METHODS : Retrospective , two-phase study of @number@ patients treated with abobotulinumtoxinA for dynamic facial rhytid reduction over an 8-month period.
METHODS : Review of literatures on calcium and bone development during childhood and bone health in adulthood and older age.
METHODS : Review of literature using PubMed and Google Scholar , references from relevant papers , and consultation with experts.
METHODS : Review of published scientific articles and unpublished research findings.
METHODS : Review of published scientific articles , census data , and unpublished research findings.
METHODS : Review of recent literature and clinical review based on own experience and own scientific results.
Methods Review of recent literature of the effect of aging and its possible effects in CRS using @number@ different databases.
METHODS : Review of the literature.
METHODS : Review of the searchable records for LN at our institution found @number@ patients , confirmed by pathology or pathognomic appearance on MRI.
METHODS : Risks of having an age-disparate relationship and number of sexual partners were compared using inverse probability of exposure weighted Poisson regression models.
METHODS : Routine clinical and demographic data were extracted from a live dental patient management system in a state-funded facility using novel methods.
METHODS : R-R intervals were recorded during 24-hour work shifts.
METHODS : RT3DE was performed in @number@ healthy subjects ( age range , 1-88 years ; @number@ men ) .
METHODS : Sal-T was measured using liquid chromatography-tandem mass spectroscopy.
METHODS : Sample included all individuals randomly assigned to reasoning training ( N = @number@ ) .
METHODS : Sarcopenia was defined according to the European Working Group of Sarcopenia in Older People consensus criteria.
METHODS : Scanners ( @number@ Tesla ) with surface coils were used at baseline and follow-up.
METHODS : Searches were performed in Medline and other databases.
METHODS : Search of electronic databases of published papers.
METHODS : Secondary analyses were carried out using cross-sectional data from @number@ women and @number@ men who participated in the NuAge longitudinal study.
METHODS : Secondary analyses were conducted on an existing dataset from a study of adults with HF.
METHODS : Secondary analysis of six waves of the Honolulu-Asia Aging Study.
METHODS : Secondary data analyses were conducted on medical record data from @number@ women who were @number@ years or older and who completed urodynamic testing.
METHODS : Secondary data analysis including @number@ women aged @number@ years and older of the Toulouse ÉPIDemiologie de l'OSteoporose cohort study.
METHODS : Secondary data analysis of a qualitative study was carried out using thematic saliency analysis.
METHODS : Secondary longitudinal analysis of dementia caregivers were recruited from eight catchment areas in the United States with 6- and 12-month post-placement follow-up data.
METHODS : Secondary outcomes included Delis-Kaplan Executive Function System ( D-KEFS ) measures of EF.
METHODS. Self-administered questionnaire on six lifestyle factors and the General Health Questionnaire 12-item version ( GHQ12 ) were administered to @number@ male workers.
METHODS : Self-reported worriers from a nationally representative survey of non-institutionalized adults were selected for investigation ( n = 1738 ) .
METHODS : Semi-structured interviews ( N = @number@ ) with senior citizens ( 65-91 years ) in a judgement sample were recorded and transcribed verbatim.
METHODS : Semi-structured interviews of @number@ residents , @number@ relatives and @number@ staff with content analysis of interview transcripts.
METHODS : Semistructured , open-ended interviews were conducted with @number@ informal caregivers and @number@ hospice providers from @number@ hospice programs in the Chicago metropolitan areas.
Methods : Sensory and cognitive functions were measured on participants in the baseline examination ( 2005-2008 ) of the Beaver Dam Offspring Study.
METHODS : Serial cross-sectional analysis of @number@ propensity-score-matched participants of BASE ( born 1907-1922 ) and BASE-II ( born 1925-1942 ) .
METHODS : Serological measurements of HP antibodies and pepsinogen I and II for CAG definition were obtained by ELISA kits.
METHODS : Serum ferritin values from @number@ consecutive patients in primary care were examined.
METHODS : Serum hydroperoxides and multimorbidity ( CIRS-CI scale ) were evaluated in @number@ Controls , @number@ MCI and @number@ LOAD.
METHODS : Serum UA and lipid profile levels were measured in @number@ AD patients and @number@ healthy controls.
METHODS : setting : This study was performed at the Kagoshima University Hospital , Japan.
METHODS : Setting : University of California , San Diego.
METHODS : Seven healthy male volunteers participated in the study.
METHODS : Seven hundred and sixty-three participants who met the inclusive criteria were divided into different age groups.
METHODS : seven-hundred fifty-seven non-nursing home residents ≥65 years from general practices in Central Copenhagen were followed for @number@ years ( 2002-2006 ) .
METHODS : Seven hundred sixty-eight nondemented adults over the age of @number@ years completed the PSS-14 questionnaire and other neuropsychological tests.
METHODS : Seventeen middle-aged participants provided blood samples for biological markers , underwent cognitive testing and a physical stress test pre- and post-intervention.
METHODS : Seventy cognitively normal community-dwelling participants were classified as SCD ( @number@ ) or controls ( @number@ ) using the Subjective Cognitive Decline Questionnaire.
METHODS : Seventy-eight Mandarin-speaking participants at a high risk ( Australian Diabetes Risk , AUSDRISK≥15 ) of developing diabetes were recruited for this study.
METHODS : Seventy-eight self-reported independent community ambulators ( mean age , @number@ years ; SD , @number@ ) participated in this study.
METHODS : Seventy-five Caucasian older community-dwellers ( mean , @number@ ± @number@ years ; 48%female ) received a blood test and brain MRI.
METHODS : Seventy-five incontinent participants ( @number@ male ) , mean age @number@ years , consented to participate.
METHODS : Seventy-five participants with MCI were assessed on measures of learning , memory , language , and executive function.
METHODS : Seventy-five patients were included in the study - @number@ consecutive patients who met the study criteria and four controls.
Methods : Seventy healthy eyes were examined with OCT to obtain nine horizontal lines in and outside of the vascular arcade.
METHODS : Seventy lung cancer patients and @number@ sex- and age-matched controls were recruited.
METHODS : Seventy-nine subjects , aged 19-70 years were recruited.
METHODS : Seventy normal subjects aged 22-70 years ( mean , @number@ ± @number@ years ) were recruited.
METHODS : Seventy-one CHF males with NYHA class II and III and @number@ control subjects age ≥ @number@ years were recruited.
METHODS : Seventy one patients underwent general anesthesia again after @number@ years in average.
METHODS : Seventy-one subjects ( ages , 55-76 yr ; apnea-hypopnea index , @date@ @number@ events / h ) were evaluated by magnetic resonance imaging.
METHODS : Seventy participants who were permanent residents of a long-term care facility were recruited for this study.
METHODS : Seventy-seven adults aged @number@ years and older were included in the multiple linear regression analyses.
METHODS : Seventy-seven community-dwelling older adults with a mean ( SD ) age of @number@ ( @number@ ) years completed comprehensive testing.
METHODS : Seventy-six patients were enrolled , and were taking @number@ mg dutasteride daily for @number@ weeks.
METHODS : Seventy-two black and @number@ white participants were screened for risk factors for depression.
METHODS : Seventy-two independent wheelchair users were recruited from four NH ( two VA-affiliated and two private ) .
METHODS : Seven women and seven men ( mean age @number@ years ) were interviewed.
METHODS : Severity of knee pain was estimated using a 10-point numeric rating scale ( NRS ) .
METHODS : Sexually active , HIV-infected MSM participating in the Veterans Aging Cohort Study were eligible for inclusion.
METHODS : SH-SY5Y cells were pretreated with curcumin , then transfected with appoptosin or vector.
METHODS : Sitting and standing systolic and diastolic blood pressures ( BP ) were measured at each wave of attendance.
METHODS : Six hundred and ninety-two asymptomatic elderly individuals ( > 55 years ) who visited for routine health check-up were included.
METHODS : Sixteen EEG channels were recorded while people with ALS or healthy age-matched volunteers ( HVs ) used a P300-based BCI.
METHODS : Sixteen healthy subjects , @number@ to @number@ years of age , participated in this double-blind , balanced , cross-over study.
METHODS : Sixteen MCI and @number@ healthy elders ( age range = 60-88 ) engaged in a supervised 12-week walking exercise intervention.
METHODS : Sixteen-year cohort of a population sample of @number@ people aged @number@ and over.
METHODS : Sixteen young controls , @number@ older adults and @number@ TBI patients underwent the HOMES test and traditional tests.
METHODS : Sixteen young , healthy adults and sixteen elderly adults participated.
METHODS : Sixty-eight patients ( 54±13 years ) with a diagnosis of nontraumatic SAH were studied.
METHODS : Sixty-five bulk-stained undecalcified human temporal bones were selected to span the ages from 30th gestational week to @number@ years.
Methods : Sixty healthy observers underwent testing on the Humphrey Field Analyzer 30-2 test grid using Goldmann ( G ) stimulus sizes I-V.
METHODS : Sixty-nine community-dwelling men and women ( 65-90 years ) were recruited.
METHODS : Sixty-nine volunteers enrolled in this cross-sectional study and were categorised into young ( 20-30 years ) and old ( ≥50 years ) groups.
METHODS : Sixty-one normal subjects aged 18-80 years participated.
METHODS : Sixty-one patients with SIS and @number@ healthy controls , aging between @number@ and @number@ years , were included in the study.
METHODS : Sixty participants were included ( @number@ with chronological aging , @number@ with photoaging , and @number@ non-skin-aged contributors as controls ) .
METHODS : Sixty patients aged ≥70 years were matched 1 : 1 with @number@ patients aged < 70 years.
METHODS : Sixty patients over @number@ years of age underwent TUVRP were compared with @number@ patients less than the age of @number@ years.
METHODS : Sixty patients were consecutively enrolled and followed for @number@ weeks.
METHODS : Sixty right ventricular outflow myocardial tissue specimens were obtained from ventricular septal defect infant patients during routine congenital cardiac surgery.
METHODS : Sixty-six aged people were evaluated.
Methods : Sixty-six patients were enrolled.
METHODS : Sixty-three children with tuberculosis treated conservatively formed the clinical material.
METHODS : Sixty-three fresh cadaveric heads were dissected to expose the facial nerve.
Methods : Sixty-two consecutive patients with idiopathic PD underwent video-polysomnographic recording and showed more than @number@ minutes of REM sleep.
METHODS : Sixty-two empirical papers relating to psychological factors associated with FrPC in community-dwelling older people ( CDOP ) were reviewed.
METHODS : Sixty-two paediatric patients with a history of HUS were included in this study.
Methods : Sixty women ( mean age @number@ years , SD @number@ ) participated.
METHODS : Six-week-old and 9-month-old CD1 mice were referred to as the ' young ' and ' aged ' groups , respectively.
METHODS : Six year follow-up data were used from the Longitudinal Aging Study Amsterdam ( LASA ) .
METHODS : Skin maceration was reproduced by exposure to agarose gel in human and rat.
METHODS : sKlotho levels were determined with ELISA in diabetic and non-diabetic patients with and without MVD , and healthy control subjects.
METHODS : Socio-demographic variables , height and weight , and self-reported diagnosed diseases were recorded at baseline.
METHODS : Specific datasets of the 2000-2011 nationwide inpatient databases were analyzed.
METHODS : Specimens of intervertebral disc tissue were obtained from @number@ patients undergoing lumbar nucleotomy.
METHODS : Split-face , randomized control trial.
METHODS : Spontaneously immortalised human skin epidermal keratinocytes ( HaCaT ) and Human Dermal Fibroblasts ( HDFn ) were divided into two groups.
METHODS : Stable glaucoma patients were randomized between the GFU and the glaucoma specialist group.
METHODS : Stakeholders were interviewed.
METHODS : standard bibliographic databases were searched for high-quality randomised controlled trials ( RCTs ) of CGA in this setting.
METHODS : Standardized questionnaires covering knowledge , practices , and obstacles were distributed among a purposive sample of GPs in Kathmandu , Nepal.
METHODS : Starting with quality-related constructs from the Institute of Medicine , we identified relevant themes by interviewing homeless patients and experts in their care.
METHODS : Statistical analysis alone , although necessary , may not always represent the practical significance of the intervention.
METHODS : Strength , mobility , leg lean mass , and physical activity assessment were used to characterize activity levels and frailty in older women.
METHODS : strength training was integrated into all stages of the programme.
METHODS : Stroke incidence data merged with population census to estimate numbers of stroke in metropolitan Melbourne , Australia.
METHODS : Structural equation modelling was used to provide a model of successful ageing , defined in subjective and objective terms.
METHODS : Structured preventive home visits by nurses or care managers were provided to the visit group every @number@ months over @number@ years.
METHODS : Studies including patients receiving injectable semi-permanent or permanent dermal fillers for age-related lines and wrinkles were included in this review.
METHODS : Studies were identified for inclusion in the review by searching the MEDLINE database via PubMed and applying strict inclusion and exclusion criteria.
METHODS : Studies were located via database searches and cross-referencing.
METHODS : Study 1 : There were @number@ experienced ACs who assessed the job requirements of apron control with the Fleishman-Job Analyses Survey.
METHODS : Study data were from @number@ diabetes screening studies in Sandy Bay Ojibway First Nation in Manitoba , collected in 2002-2003 and 2011-2012.
METHODS : Study data were obtained through systematic review of the literature.
METHODS : Study @number@ allowed for the development of a structured inventory of nightstand use today in assisted living and rehabilitation facilities.
METHODS : Study participants were identified using data from five osteoporosis clinical trials , where healthy participants had full-body dual-energy x-ray absorptiometry scans.
METHODS : Study participants were @number@ adults within the WHO Study on global AGEing and adult health ( SAGE ) , surveyed 2007-2010.
METHODS : Study participants were @number@ male inmates in a maximum security prison.
METHODS : Study population consisted of @number@ patients retrospectively reviewed undergoing repair of intrathoracic stomach from @number@ to @number@
METHODS : Study subjects were drawn from the longitudinal Physicians ' Health Study ( PHS ) .
METHODS : Study subjects were patients ≥65 years of age scheduled for major noncardiac surgery.
METHODS : Subconfluent fibroblasts were cultured and divided into normal control group , astragaloside group , UVA irradiation group and UVA plus astragaloside group.
METHODS : Subjects ≥18 years old with moderate / severe NLFs were recruited ( N = @number@ ) .
METHODS : Subjects aged 20-79 who had been receiving health examinations at a university hospital were enrolled.
METHODS : Subjects grasped the handle of a horizontal planar robot , with their arm and the robot hidden from view.
METHODS : Subjects included @number@ older persons from the Rush Memory and Aging Project without dementia , stroke , or Parkinson's disease at baseline.
METHODS : Subjects included @number@ participants aged @number@ to @number@ years in the @number@ Canada Fitness Survey , who were re-evaluated in @date@ .
METHODS : Subjects included one AD case , eight cases of sporadic IBM , and three cases of DMRV.
METHODS : Subjects in this study included @number@ healthy subjects aged 20-89 years and @number@ persons with AD aged 62-85 years.
METHODS : Subjects performed the unsupported trunk holding test until exhaustion.
METHODS : SUBJECTS : SHARE Wave @number@ respondents ( @number@ females and @number@ males ) .
METHODS : Subjects suffering from posterior cervical pain without irradiation to surrounding tissues were enrolled.
METHODS : Subjects were Blacks and Whites from an observational study of blood pressure regulation.
METHODS : Subjects were @number@ ≥ 53-year old Taiwanese who completed both the @number@ and @number@ \ "Taiwan Longitudinal Study on Aging \ " surveys.
METHODS : Subjects were @number@ healthy older individuals over @number@ years old in Tone town , Ibaraki prefecture.
METHODS : Subjects were @number@ older controls , @number@ young adult controls , and @number@ individuals with binocular AMD.
METHODS : Subjects were @number@ people aged 60-96 participating in a Swedish longitudinal multi-center cohort study.
METHODS : Subjects were participants of the Longitudinal Aging Study Amsterdam ( LASA ) .
METHODS : Subjects who underwent ER for gastric neoplasm at the Asan Medical Center from @date@ to @date@ were included.
METHODS : Subjects who underwent routine health checkups , and were above @number@ years of age , were enrolled.
METHODS : Sum scores of expert ratings were calculated and then validated against objective data collected from a prospective longitudinal study.
METHODS : Surface light scattering was reproduced experimentally by acceleratedly aging @number@ intraocular lenses by @number@ @number@ @number@ and @number@ years each.
METHODS : Surveyed a convenience sample of middle-aged and older adults ( N = @number@ ) at a metropolitan park agency in the Midwest.
METHODS : Survey of Latina and non-Latina white women diagnosed with DCIS.
METHODS : Survey responses were combined with audiometric data from a retrospective cohort of @number@ Lynx and @number@ Apache pilots.
METHODS : Surveys were collected from @number@ adults with spinal cord injury , neuromuscular disease , multiple sclerosis , or post-polio syndrome.
METHODS : Symptom data from one Australian study and two U.S. studies were combined to conduct this analysis.
METHODS : Systematic literature review using the keywords ' accidental fall / numerical data ' and ' risk factors'.
METHODS : Systematic review of published research studies examining African American preferences related to end-of-life care and decision-making.
METHODS : Systematic review of qualitative studies on the perspectives of physical activity among people aged @number@ years and over.
METHODS : Systematic reviews of clinical trials , observational studies , case series , and review articles were conducted.
METHODS : Systematic reviews were conducted to source age-specific and sex-specific epidemiological data for hip and knee OA prevalence , incidence and mortality risk.
METHODS : systematic review with meta-analysis of randomised controlled trials.
METHODS : Systematic searches of databases were conducted for literature published in peer-reviewed journals between @date@ and @date@ .
METHODS : TaqMan qPCR assays were developed to quantify @number@ common CNVs in @number@ senior American Caucasians in order to reveal possible association with longevity.
METHODS : TaqMan Real-Time PCR , UV irradiation , knockdown experiments , immunostaining , electron microscopy , collagen degradation assay , collagen crosslink analysis.
METHODS : TASM was measured by dual-energy X-ray absorptiometry , and the relative change in TASM was calculated.
METHODS : Technology-Based Eye Care Services was established in @number@ primary care clinics in Georgia surrounding the Atlanta Veterans Affairs hospital.
METHODS : Telomere length in whole blood was measured by quantitative real-time polymerase chain reaction.
METHODS : Telomere lengths of @number@ healthy persons are measured with real-time PCR in blood cells.
METHODS : telomere length was measured by PCR ( T / S ratio ) .
METHODS : Temporal bones were removed at autopsy and studied using light microscopy.
METHODS : Ten children with DS and eight healthy control subjects were included in the study.
METHODS : Ten community- dwelling older women ( 73-83 yrs ) had FDG PET and VO2 measured while walking at a comfortable speed.
METHODS : Ten fresh cadaver heads were obtained from The University of Texas Southwestern Willed Body Program.
METHODS : Ten fresh-frozen cephalic foreheads ( @number@ male , @number@ female ) were injected with radiopaque material using both needles and cannulas.
METHODS : Ten healthy , lean men were included in a nonrandomized , crossover , intervention study.
METHODS : Ten healthy women ( @number@ ± @number@ yrs ; @number@ ± @number@ BMI ) participated in a five-week physical activity program.
METHODS : Ten male subjects had the Achilles tendon moment arm length , Achilles tendon cross sectional area and free Achilles tendon length determined.
METHODS : Ten older and @number@ young adults completed step-downs from three heights.
METHODS : Ten participants ( age 65 + ) living at home were interviewed in the participants ' own homes.
METHODS : Ten patients with patch- or plaque-type MF affecting less than @percent@ body surface area were included in a prospective study.
METHODS : Ten seniors ( 74-90 years of age ) were trained to become peer educators and mentors and deliver the intervention.
METHODS : Ten subjects with mild decline in cognition ( mean , @number@.2±4.7years ; @percent@ female ) were included in this analysis.
METHODS : Ten young adults ( @number@.6±4.3 years ) and seven community dwelling older men ( @number@.9±3.8 years ) were tested during a single session.
METHODS : Tests employed were the auditory 3-stimulus oddball and the N-back.
Methods that can easily distinguish between these diseases have been devised.
METHODS : The 12S rRNA gene polymorphisms were detected by direct sequencing.
Methods : The 2011-2012 Statistics Canada Canadian Community Health Survey ( CCHS ) provided the data.
METHODS : The 3D procedure was carried out over the course of five sessions with @number@ day intervals between sessions.
METHODS : The Achilles tendons of @number@ Sprague Dawley rats received full-thickness rectangular defects.
METHODS : The age of @number@ ACA patients was compared with that of patients with other manifestations of Lyme borreliosis.
METHODS : The alternating serial reaction time task ( ASRTT ) was used.
METHODS : The analysis included @number@ PD cases and @number@ controls , all non-Hispanic Whites.
METHODS : The analysis includes @number@ men and women ( born 1907-1935 ) participating in the Age , Gene , Environment Susceptibility-Reykjavik Study.
METHODS : The analysis of the predictors of attrition rate was performed on data collected in a Web-based randomized control trial.
METHODS : The ANU-ADRI was computed for the baseline assessment of @number@ participants in the Personality and Total Health ( PATH ) Through Life project.
METHODS : The applied methodology was pre-specified in a rigorous protocol.
METHODS : The article is based on the results of surveys conducted among @number@ employees of the SME sector from Finland , Lithuania and Sweden.
METHODS : the ( ATBC ) Study recruited males aged 50-69 years who smoked at least five cigarettes per day at the baseline.
METHODS The authors analyzed data from their institutional spina bifida research database including all patients with MMC and shunted hydrocephalus.
METHODS : The authors carried out a retrospective study , evaluating results and early postoperative complications in patients aged @number@ years and older.
METHODS : The authors examined myocardial function in a retrospective cross-sectional study from a cohort of AD patients and age-matched controls.
METHODS : The authors refined the SQA test case scenario for content , ease of modifications of case scenarios , test uploading and answer retrieval.
METHODS : The authors treated @number@ patients ( a total of @number@ treatment sessions ) with the AirGent system between @date@ and @date@ .
METHODS : The authors used geocoded data from the Health in Men Study collected in Western Australia in @number@ ( N = @number@ ) .
METHODS : The authors used population-based , cross-sectional surveys , the Collaborative Psychiatric Epidemiology Surveys.
METHODS : The authors used two methods on two patient collectives.
METHODS : The bilateral feet of @number@ healthy volunteers and @number@ patients with plantar fasciitis were examined with SWE.
METHODS : The birth certificates of @number@ individuals born 1914-1916 in @number@ districts of the Paris region were retrieved.
METHODS : The BOSS ( 2005-2008 ) is a study of aging in the adult offspring of the population-based Epidemiology of Hearing Loss Study cohort.
METHODS : The butanolic extraction of C. fistula flowers was completed and the active compounds were classified.
METHODS : The Canadian Malnutrition Task Force conducted a prospective cohort study in medical and surgical wards of @number@ Canadian hospitals.
METHODS : The cardiocerebrovascular death data of Hunan residents were collected by three national retrospective sample surveys of death.
METHODS : The case notes of patients attended to from @date@ to @date@ were analyzed.
METHODS : The CAVI and peripheral BP were determined in healthy , normotensive Koreans @number@ to @number@ years of age.
METHODS : The CCT of @number@ patients was measured using an ultrasound pachymeter.
METHODS : The Chicago Health and Aging Project ( CHAP ) cohort is a population-based study ( n = @number@ ) .
METHODS : The Chicago Health and Aging Project ( CHAP ) is a prospective population-based cohort study that began in @number@
METHODS : The Chicago Healthy Aging Project is a population-based cohort study conducted from @number@ to @number@
METHODS : The CIMP status and other molecular tumour features were analysed in @number@ CRC patients diagnosed between @number@ and @number@
METHODS : The clinical data of @number@ AFOP patients were retrospectively analyzed.
METHODS : the clinical data of @number@ patients of SAFS from this hospital were presented , and the related literatures reviewed.
METHODS : The clinical data of @number@ patients undergoing pancreaticoduodenectomy from @date@ to @date@ were analyzed retrospectively.
METHODS : The clinical data of @number@ patients with CFBA were retrospectively analyzed.
METHODS : The Clinical Dementia Rating scale and the Clock Drawing Test ( CDT ) were administered.
METHODS : The clinical features , auxiliary examinations and diagnosis of a case with DLBCL were reported and the related literatures were reviewed.
METHODS : The clinical records of patients who were hospitalized in Higashisumiyoshi Morimoto Hospital for chest trauma between @date@ and @date@ were retrospectively reviewed.
METHODS : The clinical study was a prospective , double-blind , randomized , and controlled study with a total of @number@ Korean women.
METHODS : The clinic data of @number@ patients with malignant pancreatic neuroendocrine tumors who were admitted between @date@ and @date@ were summarized.
METHODS : The Coach2Move strategy was developed on the basis of @number@ systematic literature studies and expert consultations.
METHODS : The Cognitive-Affective Judgement of Preference Test was administered to @number@ patients with ALS and @number@ controls.
METHODS : The complete data of @number@ patients with CFC were collected and initial database was established with Epidata @number@
METHODS : The concentration of serum folate was determined by the Access ImmunoAssay System Sanofi Pasteur.
METHODS : The Concord Health and Ageing in Men Project is a population-based study in Sydney , Australia , involving @number@ men aged 70-97.
METHODS : The consensus conference was conducted with gerontological experts from various disciplines and environmental scientists.
METHODS : The Copenhagen Perinatal Cohort is comprised of children born in Copenhagen from @number@ to @number@
METHODS : The criterion validity of accuracy was established under controlled conditions using an instrumented Gimbal table.
METHODS : The CSES is a self-administered questionnaire developed on the basis of Bandura's self-efficacy theory.
METHODS : The current study adopted the retrospective observational study design.
METHODS : The current study data are from the Mater-University of Queensland Study of Pregnancy birth cohort.
METHODS : The Danish @number@ Cohort Survey is a nationwide , longitudinal survey comprising all individuals born in Denmark in @number@
METHODS : The data are based on an Italian multicenter population-based cohort study with both cross-sectional and longitudinal components.
METHODS : The data consists of @number@ cases of death from @number@ Koreans at 20-93 years old , surveyed from @number@ to @number@
METHODS : The data of prostate cancer cases were provided by the Tianjin Cancer Registry.
METHODS : The data source for this study was the Survey of Income and Program Participation @number@
METHODS : the data source was a mailed survey in the Vitality 90 + study ( n = @number@ ) in @number@
METHODS : The data was obtained from computed tomography ( CT ) scans of more than @number@ patients aged @number@ and older.
METHODS : The data were collected in @number@ among all residents of Turku , Finland , born in @number@ ( N = @number@ ) .
METHODS : The data were derived from national registers and from samples of 75-year old living in Denmark , Sweden , and Finland.
METHODS : The data were from a nation-representative panel of older people in Taiwan.
METHODS : The data were from the ' Project of Longevity and Aging in Dujiangyan ' study.
METHODS : The data were gathered from surveys of @number@ patients participating in the LIFE survey from @date@ to @date@ .
METHODS : The design was a 2×4 , prospective , randomized controlled clinical trial.
METHODS : The diameter of each hair has been measured using an optical microscope equipped with a digital camera.
METHODS : The dietary intake was measured using a validated 141-item food frequency questionnaire.
METHODS : The donor and recipient sites in @number@ cadaveric knees were examined , and each of the sites was divided into @number@ areas.
METHODS : The double-echo chemical shift gradient-echo magnetic resonance imaging technique was used in this study.
METHODS : The effect of a non-cross-linked HA on proliferation , migration and gene expression of human dermal fibroblasts was determined.
METHODS : The effects of a multinutrient supplement on mobility and cognition were assessed in postmenopausal women ( 60-84 years ) .
METHODS : The EPIC-Norfolk Eye Study is nested within a multicenter cohort study the European Prospective Investigation of Cancer.
METHODS : The epidemiology of azole resistance in IA was analysed in two German haematology departments.
METHODS : The Ergonomic Methodology for the Built Environment was applied.
METHODS : The estimated figures were obtained by applying the MIAMOD method.
METHODS : The EVITAL cohort included @number@ participants admitted to the CBUs of @number@ French hospitals.
METHODS : The examination included visual acuity measurement , dilatation , and anterior and posterior segment examination.
METHODS : The Exogen Bone Healing System is a LIPUS device approved in @number@ to accelerate healing of fresh fracture.
METHODS : The experimental group comprised @number@ older women with lumbar spondyloarthrosis , aged between @number@ and @number@ years.
METHODS : The expression level of TUG1 , miR-421 and caspase-3 were detected by RT-qPCR.
METHODS : The FaB was adapted in French Canadian ( FaB-FC ) and validated according to standard guidelines for cross-cultural adaptation of questionnaires.
METHODS : The first phase of the Shahroud Eye Cohort Study is a cross-sectional population-based study in Iranian subjects @number@ to @number@ years old.
METHODS : The FRASER program is a multicenter prospective study involving @number@ Italian cardiology units.
METHODS : The German Chronic Kidney Disease ( GCKD ) study is an ongoing prospective cohort study including patients with CKD of moderate severity.
METHODS : The GOLDN GWAS discovery sample consisted of @number@ participants within families of European ancestry.
METHODS : The Guideline methodology adhered to the Appraisal of Guidelines for Research and Evaluation ( AGREE ) II criteria.
METHODS : The handrail and cueing system was mounted on a large ( @number@ m×6 m ) motion platform configured to simulate a real-life environment.
METHODS : The Helsinki Health Study cohort includes Finnish municipal employees aged @number@ to @number@ in @date@ ( phase @number@ response rate @percent@ ) .
METHODS : The Honolulu Asia-Aging Study is a longitudinal study of Japanese-American men based on the Honolulu Heart Study birth cohort.
METHODS : The Honolulu-Asia Aging Study is a prospective cohort study of Japanese American men in Honolulu , HI.
METHODS : The Honolulu-Asia Aging Study is a prospective , community-based cohort study of Japanese American men conducted in Honolulu , Hawaii.
METHODS : The Honolulu Heart Program is a prospective study that began in @number@ with @number@ Japanese-American men aged @number@ to @number@ years.
METHODS : The human VSMC differentiation model was established by beta-glycerophosphate ( β-GP ) induction.
METHODS : The hyoid bones of @number@ adult corpses were dissected from redundant soft tissues after heating.
METHODS : The hypothesis starts from a new , biochemical view on evolution and the behavior of living matter.
METHODS : The hypothesis was tested in a sample of @number@ older adults recruited from a primary care setting.
METHODS : The ImmunoCAP assay was employed to detect serum total IgE and sIgE.
METHODS : The incidence of hip fracture was computed from three regional estimates and used to construct a country-specific FRAX model for the Ukraine.
Methods : The individuals were categorized in two groups according to the presence or absence of cognitive decline.
METHODS : The Institute of Occupational Health of Macedonia developed an specially designed questionnaire in collaboration with the WHO Regional Office for Europe.
METHODS : The integrative review was conducted using PubMed , CINAHL , Web of Science , PsycInfo , and ProQuest Dissertations and Theses.
METHODS : the intervention group attended a 60-min multimodal class twice each week which included cardiovascular , strength and motor fitness training.
METHODS : The Invecchiare in Chianti ( InCHIANTI ) Study is a prospective cohort study set in the Chianti area ( Italy ) .
METHODS : The investigation included two 52-week , double-blind , vehicle-controlled studies.
METHODS : The IOM report is based on a consensus of literature and expert opinion.
METHODS : The IOP measurements were obtained using the RBT and GAT , and CCT was measured using a specular-type microscope.
METHODS : The IPS was evaluated using trail making test ( TMT ) and flanker test ( n = @number@ ) .
METHODS : The Italian version of the NPI-NH was administered in @number@ patients in a nursing home in Northern-Italy.
METHODS : The Japanese database Ichushi Ver.
METHODS : The Korean national health claims database was analyzed to identify patients with RVO.
METHODS : The Lipo-Facelift procedure consists of facial liposculpturing performed simultaneously with a biplanar , bivectorial SMAS face-lift procedure.
METHODS : The literature from @number@ to @number@ on the effectiveness of stroke educational campaigns was reviewed and summarized with narrative synthesis.
METHODS : The literature search was conducted using three online databases restricted to the timeframe from @date@ to @date@ .
METHODS : The literature was searched for studies with at least @number@ patients on medical or geriatric wards.
METHODS : The literature was systematically searched for studies focusing on interventions targeting memory impairment in MCI using relevant search terms.
METHODS : The LM immediate ( LM-I ) and LM delay ( LM-D ) free recall correct responses and related and unrelated errors were scored.
METHODS : The Londrina ADL protocol was created based on activities included in previous studies aimed at investigating outcomes from ADL.
METHODS : The long range development ( @number@ years ) of human resources in the hospitals of the City of Cologne was analyzed.
METHODS : The main PUN class investigated to date , i.e. UN , can only account for the overall growth pattern.
METHODS : The Male Breast Cancer Pooling Project consortium provided @number@ cases and @number@ controls for analysis from @number@ case-control and @number@ cohort studies.
METHODS : The mandibular cortical width was measured in @number@ dental panoramic tomograms , in patients aged 15-94 years.
METHODS : The median age of the patients was @number@ years , and @number@ percent of the patients were women.
METHODS : The medical records of @number@ patients with BC followed between 1994-2015 were retrospectively analyzed.
METHODS : The medical records were reviewed of patients received IFX from @date@ to @date@ .
METHODS : The Memory-HEARS pilot study delivered a 2-hour in-person intervention in an outpatient setting.
METHODS : The methodology was conducted and documented systematically and transparently using a narrative approach.
METHODS : The MOBILIZE Boston Study included @number@ adults aged ≥70 years , living in the Boston area , recruited from @number@ to @number@
METHODS : The models allow simultaneous prediction of outcomes from double embryo transfer ( DET ) and SET.
METHODS : The modified Fecal Incontinence Severity Index ( FISI ) was administered at @number@ @number@ and @number@ months in @number@ women.
METHODS : The MRC CFAS is a multicentred longitudinal survey of a population representative sample of people in their 65th year and older at baseline.
METHODS : The national hospital discharge database was analyzed in order to analyze hospitalizations related to cancer care in ≥75 years patients for year @number@
METHODS : The Nationwide Inpatient Sample ( 2010-2012 ) was queried for laparoscopic cholecystectomy.
METHODS : The Nationwide Inpatient Sample database from @number@ to @number@ was used to identify patients who underwent surgery for a primary spinal tumor.
METHODS : The Normative Aging Study is a prospective cohort study of men in the greater Boston area.
METHODS : The NuAge cohort study enrolled @number@ men and women aged 68-82 years.
METHODS : The NU-AGE study is a parallel randomized one-year trial in @number@ apparently healthy , independently living European participants aged 65-80 years.
METHODS : The @number@ and Up Study is a large Australian prospective cohort study ( n = @number@ ) .
METHODS : The @number@ inhibitory functions were measured using a sequential flanker task.
METHODS : The number of FMR1 CGG repeat was determined in @number@ Han Chinese women with well-defined @number@ XX non-syndromic sporadic POF and @number@ controls.
METHODS : The Nurses ' Health Study II is a prospective study of US female nurses enrolled in @number@ ( ages 24-44 years ) .
METHODS : The nursing managers at all @number@ NHs in County Galway in the West of Ireland were invited to participate.
METHODS : The NY State Cancer Registry and Statewide Planning and Research Cooperative System identified stage I-III colon cancer resections ( 2004-2011 ) .
METHODS : The NYUCI-AC was evaluated within a single-blinded randomized controlled trial.
METHODS : The observational study presented involved @number@ adult DS persons.
METHODS : The offspring of @number@ pregnant women ( @number@ non-diabetic controls , @number@ with diet- or insulin-controlled GDM ) were recruited before delivery.
METHODS : The OLQ-13 scale was administered as part of a healthy aging project for non-institutionalized people aged @number@ years and older.
METHODS : The optimum case definition of RA for the study was the American College of Rheumatology @number@ criteria.
METHODS : The original protocol was tested on different chemistry analyzers and then simplified at the University of Washington ( UW ) .
METHODS : The outcome variable was the motivation to choose gerontological nursing as a career.
METHODS : The PACSLAC was revised based on the relevant clinical and theoretical literature.
METHODS : The panel data are from two waves of the Norwegian Study on the Life Course , Ageing and Generations ( NorLAG ) .
METHODS : The Panel Study of Belgian Households is a prospective longitudinal survey , following adults ages 25-74 , annually from @number@ to @number@
METHODS : The participants come from the sixth wave of a nationwide survey of older adults ( N = @number@ ) .
METHODS : The participants comprised @number@ elderly people with mild MDD and @number@ matched controls.
METHODS : The participants comprised @number@ nondemented adults , aged 55-91 years , recruited from Alzheimer's Disease Neuroimaging Initiative sites.
METHODS : The participants had undergone medical check-ups at the Center for Preventive Medicine of St Luke's International Hospital between @number@ and @number@
METHODS : The participants included @number@ ( @number@ men , @number@ women ) community-dwelling elderly Japanese individuals aged ≥65 years.
METHODS : The participants of a 4-year randomized controlled trial were a population sample of @number@ men and women aged @number@ to @number@ years.
Methods : The participants underwent a comprehensive ophthalmic examination that included AL , cycloplegic refraction , and Pentacam measurements.
METHODS : The participants were derived from a population-based Helsinki Aging Study , a random sample of 76- , 81- and 86-year-old elderly.
METHODS : The participants were @number@ community-dwelling older adults ( mean age , @number@ ± @number@ years ) .
METHODS : The participants were @number@ individuals ( age range 60-81years ) and followed for 10years and tested six times.
METHODS : The patients were monitored from the first day of hospitalisation through the discharge.
METHODS : The Pediatric Quality of Life Inventory Generic Core Scales and Cardiac Module were administered to @number@ children who had previously undergone heart transplantation.
METHODS : The Penn Ovarian Aging Study cohort was monitored for @number@ years.
METHODS : The PHARMAID study is a 18-month randomized controlled trial that started in @date@ .
METHODS : The phytochemical contents of the plant extracts were investigated for radical scavenging activity and total reducing power.
METHODS : The PINE study is an epidemiological cohort of @number@ community-dwelling Chinese older adults , @percent@ of whom do not speak or read English.
METHODS : The plasma levels of GDF11 were investigated in two separate cohorts by western blotting.
METHODS : The population-based Beijing Eye Study @number@ included @number@ individuals.
METHODS : The population-based Central India Eye and Medical Study included @number@ subjects.
METHODS : The population sample consisted of @number@ French-speaking older adults from Québec ( Canada ) aged between @number@ and @number@ years.
METHODS : The Population Study of Chinese Elderly in Chicago enrolled an epidemiological cohort of @number@ community-dwelling Chinese older adults aged @number@ and older.
METHODS : The Population Study of Chinese Elderly in Chicago Study enrolled an epidemiological cohort of @number@ community-dwelling Chinese older adults.
METHODS : The present 3-year prospective study was a part of the Bangkok Longitudinal Study by Siriraj Hospital for Older Men and Women.
METHODS : The present article draws on data from the Housing Opportunities & Mobility in the Elderly study.
METHODS : The present quasiexperimental study was conducted on @number@ hypertensive elderly persons from Qom , Iran.
METHODS : The present retrospective cohort study used data from the Veteran Affairs Comprehensive Geriatric Assessment from @date@ to @date@ for analysis.
METHODS : The present study comprised data from subjects included in the @number@ Project of Longevity and Aging in Dujiangyan , China.
METHODS : The present study examined VC in @number@ kidney transplant ( KT ) recipients who had been transplanted for longer than one year.
METHODS : The present study included @number@ patients who underwent either surgical or transcatheter aortic valve replacement and 1-year postoperative echocardiography.
METHODS : The prevalence of @number@ risk factors was recorded at a baseline assessment of @number@ subjects ( aged 60-93 years ) .
METHODS : The primary objective of this study was to evaluate the safety of IVZ in Japanese patients.
METHODS : The primary outcome measure for intervention with lonafarnib was to assess increase over pretherapy in estimated annual rate of weight gain.
METHODS : The prognostic model was developed in @number@ individuals from the Rotterdam Study-I ( RS-I ) .
METHODS : The program was developed using a logic model and evaluated using program evaluation methodology.
METHODS : The project consisted of a systematic literature review and a consensus process.
METHODS : The proposed system is composed of a three-tier architecture : the front-end tier , the mobile tier and the cloud tier.
METHODS : The proposition of the ICF core set was based on the Delphi technique.
METHODS : The prospective nonrandomized controlled trial reported here was performed in three hospitals in the Netherlands.
METHODS : The prospective study included @number@ stroke-free participants aged 42-81 years from the European Prospective Investigation into Cancer-Norfolk cohort.
METHODS : The psychosocial group rehabilitation intervention was evaluated from the group leaders ' diaries and by observing the groups.
METHODS : The PubMed , Web of Science , ScienceDirect and CNKI databases were searched updated to @date@ .
METHODS : The Queensland Suicide Register was utilized for the analysis.
METHODS : The randomized controlled trial was conducted across multiple US offices of a large global information technology company.
METHODS : The rat model of Alzheimer's disease ( AD ) was established using D-galactose to cause subacute aging combined with Meynert nucleus damage.
METHODS : The recent literature about miRNA in skin development and wound healing was reviewed and analyzed.
METHODS : The records of all patients with idiopathic scoliosis who received surgical treatment from @date@ to @date@ at our hospital were screened.
METHODS : The registry consisted of data from @number@ patients treated with coronary interventions using either DES-I or DES-II stents.
METHODS : The relationships between RLS and potential secondary causes were examined in hospital patients aged 50years or more.
METHODS : The relevant literature was reviewed using PubMed.
METHODS : The research group consisted of @number@ male professional field hockey players.
METHODS : The resting electrocardiogram ( ECG ) permits us to suspect or diagnose a large number of cardiac disorders.
METHODS : The retinyl retinoate microsphere was prepared using the biodegradable polymer ; polylactic acid ( PLA ) .
METHODS : The review followed PRISMA guidelines.
METHODS : the review methodology followed Cochrane procedures.
METHODS : The review was based on expert surveys and interviews with caregivers in nursing homes and psychiatric hospitals.
METHODS : There were @number@ cognitively normal aging subjects included in this study.
METHODS : The Rose Research firm conducted an internet survey of female consumers provided by Lightspeed Global Market Insite.
METHODS : The same patient group was reinvestigated in @number@ using the same MRI scanner and acquisition protocol.
METHODS : The sample comprised Lothian Birth Cohort @number@ ( LBC1921 ) participants seen at a mean of about @number@ and @number@ years of age.
METHODS : The sample comprised @number@ individuals ( @percent@ male , @percent@ white ) .
METHODS : The sample comprised @number@ patients enrolled in a naturalistic treatment study.
METHODS : The sample consisted of @number@ participants aged ≥50 years from the Survey of Health , Ageing and Retirement in Europe.
METHODS : The sample consisted of @number@ participants with childhood-onset epilepsy and @number@ age-matched healthy controls aged 48-63 years.
METHODS : The sample consists of @number@ non-demented community-dwelling older participants aged @number@ years or over.
METHODS : The sample for this investigation involved N = @number@ subjects ( @number@ to @number@ years old ) .
METHODS : The sample included @number@ elderly parents aged @number@ years and older.
METHODS : The sample included @number@ individuals above age @number@ who participated in the Health and Retirement Study between @number@ and @number@
METHODS : The sample included @number@ middle-aged and older African Americans examined in Wave @number@ of the African American Health ( AAH ) study.
METHODS : The sample included @number@ non-cognitively impaired older adults aged 65 + and @number@ older adults diagnosed with amnestic MCI ( aMCI ) .
METHODS : The sample included @number@ subjects aged @number@ years and older.
METHODS : The sample included @number@ young adults ages @number@ to @number@ who had been discharged from inpatient psychiatric care in a mid-Atlantic state.
METHODS : The samples of peripheral blood stains were collected from @number@ healthy unrelated individuals whose ages were known.
METHODS : The samples were selected by random cluster multistage method.
METHODS : The sample was drawn from the HRS and included @number@ community-dwelling older adults.
METHODS : The sample was @number@ dental panoramic radiographs of dental patients aged 3-16.
METHODS : The scanning peripheral ACD analyzer evaluated ACD by numeric grade ( ACDG @number@ to @number@ ) and ACA twice in @number@ and @number@
METHODS : The schizophrenia group consisted of @number@ community-dwelling persons aged @number@ years and older who developed schizophrenia before the age of @number@ years.
METHODS : The SCZ cohort comprised @number@ SCZ patients and @number@ controls ( aged 20-60 years ) .
METHODS : The search identified @number@ articles of which @number@ articles were included in the review.
METHODS : The search was carried out by querying an electronic database and hand searching.
METHODS : The Second Injury Control and Risk Survey ( ICARIS-2 ) was a nationwide cross-sectional , list-assisted random-digit-dial telephone survey from @number@ to @number@
METHODS : The sepsis-related mortality data from @number@ and @number@ were retrieved from the China Health Statistical Yearbook.
METHODS : The Shihpai Eye Study @number@ included @number@ ( @percent@ ) of @number@ participants in the @number@ baseline survey for a follow-up eye examination.
METHODS : The skin on the knee of @number@ healthy Korean female volunteers , divided into two groups young and old , were photographed.
METHODS : The Skin Products Assessment Research study was designed as a multicenter , double-blind , randomized , controlled trial.
METHODS : The socioeconomic indicators for this study were obtained from the database of the United Nations Development Programme.
METHODS : The standardized effect of age on muscle fatigue was computed for @number@ studies ( @number@ standardized effects ) .
METHODS : The statistical population of this cross-sectional survey consisted of residents of urban and rural areas in Iranian provinces.
Methods : The Strategic Highway Research Program ( SHRP2 ) Naturalistic Driving Study was used for this prospective analysis.
METHODS : The studies were carried out using an SEM ( scanning electron microscope ) , a TriboIndenter and an artificial finger.
METHODS : The study adopted a qualitative approach , with individual interviews conducted among eight people diagnosed with early-stage dementia.
METHODS : The study cohort consisted of individuals , ≥65 years in @number@ residing in the Region Västra Götaland during 2005-2010.
METHODS : The study cohort ( n = @number@ ) was selected from the database of the largest health insurance provider of the Slovak Republic.
METHODS : The study comprised two phases.
METHODS : The study conducts semi-structured interviews with @number@ senior OFE users at two parks in Taiwan.
METHODS : The study consisted of older adults living in shared apartment communities including caregiving.
METHODS : The study design was a survey of EPEC trainers and documentation of other dissemination efforts via literature and Internet searches.
METHODS : The study design was cross-sectional.
METHODS : The study design was cross-sectional and population based.
METHODS : The study employed a population-based nested case-control design using 2007-2010 Minimum Data Set ( MDS ) -linked Medicare data from all states.
METHODS : The study enrolled elderly patients with OSAHS and age-matched healthy control subjects.
METHODS : The study enrolled @number@ patients diagnosed with lower urinary tract symptoms secondary to BPH during the period @date@ to @date@ .
METHODS : The study followed a cross-sectional design involving a nationally representative sample of @number@ community-dwelling adults aged @number@ years and older in Spain.
METHODS : The study group consisted men with diagnosed benign prostatic hyperplasia.
METHODS : The study group consisted of @number@ patients with senile cataract undergoing cataract extraction surgery.
METHODS : The study group included @number@ subjects , mean age @number@ ±13.3 years , free of known cardiovascular diseases and regular drug consumption.
METHODS : The study included a population sample of @number@ men and women , of mean age @number@ ± @number@ years.
METHODS : The study included a total of @number@ persons aged 76-100 years ( mean @number@ ± @number@ ) .
METHODS : The study included methadone patients between @date@ and @date@ .
METHODS : The study included @number@ allo-HSCT recipients from the University Hospital of Cologne detected BKPyV positive by real-time PCR between @number@ and @number@
METHODS : The study included @number@ community dwelling older adults aged @number@ or above from the Shanghai Aging Study.
METHODS : The study included @number@ consecutive patients who underwent effective RA between @date@ and @date@ .
METHODS : The study included @number@ elderly GAD and @number@ non-anxious comparison participants.
METHODS : The study included @number@ men aged @number@ years or older , living in the urban area of Pelotas , Southern Brazil.
METHODS : The study included @number@ men @number@ to @number@ years old who underwent a general health checkup.
METHODS : The study included @number@ officially-acknowledged victims of pollution-related illness living in Kurashiki , Okayama who were aged ≥ @number@ years in @number@
METHODS : The study included @number@ outpatients with type @number@ diabetes mellitus.
METHODS : The study included @number@ participants aged 63-97 years assessed four times over a six-year period.
METHODS : The study included @number@ patients aged @number@ ± @number@ with diagnosed AF.
METHODS : The study included @number@ postmenopausal women.
METHODS : The study included @number@ randomly selected women.
METHODS : The study included @number@ residents through a large health check-up program in Beijing.
METHODS : The study included @number@ self-reported healthy adults , aged 65-84 years ( mean @number@ SD @number@ years ) .
METHODS : The study included @number@ subjects who underwent coronary angiography and @number@ patients who underwent elective cardiac surgery recruited between @date@ and @date@ .
METHODS : The study included @number@ women ( aged @number@.8±7.4 ) , and the control group comprised of @number@ women of corresponding age.
METHODS : The study included one hundred twenty six subjects.
METHODS : The study investigated fecal continence assessment among women who gave birth to their first child @number@ @number@ or @number@ years previously.
METHODS : The study involved a literature search for articles retrieved from PubMed using FoxO3 as keyword.
METHODS : The study involved a sample of the Jordanian population that included @number@ type @number@ diabetic patients and @number@ control subjects.
METHODS : The study involved a total number of @number@ patients ( @number@ eyes ) with senile cataracts.
METHODS : The study is a multicenter , parallel-group , randomized controlled trial.
Methods : The study is based on a longitudinal cohort design.
METHODS : The study is based on an epidemiological survey conducted in Sør-Trøndelag county , Norway , in 1985-86.
METHODS : The study is based on the Survey on Disability , Personal Autonomy and Dependency Situations ( Spanish National Statistics Institute ) .
METHODS : The Study of Mental and Resistance Training was a randomized , double-blind , double-sham controlled trial of adults with MCI.
METHODS : The study participants were @number@ Japanese patients without a history of cardiovascular disease treated in our outpatient department.
METHODS : The study population comprised @number@ French middle-aged women between @number@ and @number@ years.
METHODS : The study population comprised of @number@ patients with IgE-mediated CMA.
METHODS : The study population consisted of @number@ patients aged @number@ years or older hospitalized for chronic heart failure.
METHODS : The study population consisted of @number@ patients consecutively admitted to our institution.
METHODS : The study population , consisting of @number@ patients who underwent endosonographic evaluation for different indications , was divided into two groups.
METHODS : The study population included @number@ consecutive patients who underwent pancreaticoduodenectomy between @date@ and @date@ .
METHODS : The study population made up of @number@ consenting participants was selected using multistage stratified random sampling technique.
METHODS : The study population originated from the French national survey ' Enquête décennale santé @number@.
METHODS : The study population was born in 1959-61 and premorbid IQ was assessed with the WAIS between @number@ and @number@
METHODS : The study population was chosen from outpatients with progressive cognitive complaint.
METHODS : The study recruited @number@ Chinese and Malay men.
METHODS : The study reviewed @number@ patients ( aged 35-97 years ) diagnosed with incarcerated hernias who underwent emergency surgery.
METHODS : The study sample consisted of adults from the Framingham Offspring cohort ( n = @number@ ) .
METHODS : The study sample consisted of a total of @number@ Caucasian children participating in the Fels Longitudinal Study.
METHODS : The study sample consisted of elderly patients who had been admitted to a rehabilitation facility in Hamburg , Germany.
METHODS : The study sample was selected from Medicare Current Beneficiary Surveys conducted between @number@ and @number@
METHODS : The study subjects consisted of @number@ males , @number@ of whom were smokers and @number@ non-smokers.
METHODS : The study used a longitudinal cohort design that compared hand function outcomes in @number@ with those obtained @number@ years earlier.
METHODS : The study used data extracted from Pharmaceutical Claims Data Mart ( Pharms ) for the year @number@
METHODS : The study used data from the District Level Household Survey , round @number@ @date@ , conducted under the Reproductive and Child Health Project.
METHODS : The study utilized a cross-sectional survey with a multistage cluster sampling design.
METHODS : The study was a randomised pragmatic trial comparing venlafaxine and sertraline in combination with psychotherapy and social counselling.
METHODS : The study was a randomized controlled trial with repeated follow-ups.
METHODS : The study was a retrospective , institutional , and comparative case series.
METHODS : The study was based on @number@ men born in @number@
METHODS : The study was based on the @number@ National Physique Monitoring data.
METHODS : The study was carried out on @number@ consecutive adult patients ( 40-93-year-old , main @number@ ) who underwent surgery for CSDH.
METHODS : The study was composed of reference group ( n = @number@ ) and the elderly group ( n = @number@ ) .
METHODS : The study was conducted among @number@ employees at a hotel in Gyeongju , Korea , from @date@ to @date@ .
METHODS : The study was conducted at a community hospital.
METHODS : The study was conducted at an academic neurology subspecialty clinic.
METHODS : The study was conducted in an ambulatory university setting.
METHODS : The study was conducted in @number@ in Agincourt ( South Africa ) , as part of the Health and Demographic Surveillance System.
METHODS : The study was conducted in patients aged @number@ years or older admitted to a teaching hospital between April and @date@ .
METHODS : The study was conducted on @number@ patients with primary diagnosis of stroke admitted for in-hospital rehabilitation.
METHODS : The study was cross-sectional in design.
METHODS : The study was on @number@ non-institutionalized Malaysian elderly.
METHODS : The study was performed in @number@ community residents ( @number@ women , aged ≥65years ) who participated in the Shanghai Heart Health Study.
METHODS : The study was performed in @number@ nursing homes across the federal state of Baden-Württemberg , Germany.
METHODS : The study was performed in @number@ subjects without a history of coronary heart disease.
METHODS : The study was performed on a general population of Turkish women.
METHODS : The study was performed within the prospective population-based Rotterdam Study.
METHODS : The study was retrospective longitudinal in design.
METHODS : The subjects comprised @number@ individuals without any spine-related neurological symptoms or treatment history thereof who visited our outpatient clinic.
METHODS : The subjects included @number@ patients with COPD ( COPD group ) and @number@ healthy controls ( control group ) .
METHODS : The subjects ( n = @number@ ) were derived from the participants in a multifactorial fall prevention intervention conducted in Pori , Finland.
METHODS : The subjects performed the WPR activity with @number@ inertial sensors attached on the thoracic spine and sacrum.
METHODS : The subjects studied were @number@ Japanese over the age of @number@ years.
METHODS : The subjects were @number@ adults and @number@ childrens who were all healthy right-handed volunteers.
METHODS : The subjects were @number@ consecutive autopsy cases ( @number@ men and @number@ women ) .
METHODS : The subjects were @number@ Japanese PD patients ( @number@ males and @number@ females ) .
METHODS : The subjects were @number@ male employees ( aged 20-59 years ) of a large-scale integrated manufacturing facility in Japan.
METHODS : The subjects were @number@ unrelated healthy Japanese volunteers.
METHODS : The survey was conducted in the region of the town of Nis.
METHODS : The symbol digit and digit span tests from the Swedish Performance Evaluation System were used to assess perceptual capacity and memory.
METHODS : The technique reported here preserves most retaining ligaments.
METHODS : The tool was translated into Arabic and tested on @number@ Saudi men.
METHODS : The uHear application was downloaded to an iPad.
METHODS : The United Network for Organ Sharing database was queried to identify IPF patients receiving lung transplant between @number@ and @number@
METHODS : The upper eyelid , lower eyelid , lateral canthus , and brow are examined , highlighting aesthetic differences in males and females.
METHODS : The UPSA-M was developed for an iPad platform.
METHODS : The VFs were visualized bilaterally during supramaximal air stimulation through an endoscope.
METHODS : The vital organ function of @number@ healthy individuals of Han origin ( age 35-91 years ) was examined.
METHODS : The writings of two philosophers , Hans-Georg Gadamer and Martin Heidegger , guided the study's design and research methods.
METHODS : They studied @number@ patients at least @number@ months after left-hemisphere subcortical strokes and @number@ healthy controls.
METHODS : Thirteen focus groups were held with @number@ acute care nurses.
METHODS : Thirteen older adults were provided in-home ICT training by graduate occupational therapy students using an iPad.
METHODS : Thirteen young healthy subjects were enrolled to undergo DKI and PSIR sequences in the cSC.
METHODS : Thirty community-dwelling older people ( age @number@ ± @number@ years , @number@ females ) were enrolled in this study.
METHODS : Thirty-eight healthy older adults ( @number@ ± @number@ years ) participated in this study.
METHODS : Thirty-eight male controls compared with @number@ opiate-dependent male patients were studied longitudinally using SphygmoCor pulse wave analysis.
METHODS : Thirty-eight participants were recruited from a university-affiliated home healthcare agency for the trial.
METHODS : Thirty-eight postmenopausal women ( mean age , @number@ y ) not taking HT participated in the study.
METHODS : Thirty elderly and @number@ young healthy subjects were recruited in this study.
METHODS : Thirty elderly individuals affected by stroke in chronic phase participated.
METHODS : Thirty-five consecutive patients with Graves disease treated by total thyroidectomy were included in the present study.
METHODS : Thirty-five older adults underwent neuropsychological testing and fasting blood draw with subsequent serum ghrelin quantification.
METHODS : Thirty-five patients were included in this retrospective study.
METHODS : Thirty-five RPE-Bruch's membrane flatmounts from @number@ donors were prepared ( postmortem : ≤4 hours ) .
METHODS : Thirty-five young ( 20-36yrs ) and @number@ older ( 55-71yrs ) recreational runners participated in the study.
METHODS : Thirty healthy older adults ( 64-79 years old ) and @number@ young university students ( 18-25 years old ) participated.
METHODS : Thirty male SD rats were randomly and equally divided into control , model , and EA groups.
METHODS : Thirty-nine elderly participants were randomized into intervention ( n = 21 ) and wait-list control ( n = 18 ) arms.
METHODS : Thirty ( @number@ ) apparently healthy men and newly diagnosed BPH patients were recruited from the Ghana Police Hospital.
METHODS : Thirty-one male patients with advanced HF , scheduled for implantation of a CRT device , were included in the study.
METHODS : thirty-one people aged between @number@ and @number@ were purposively sampled from respondents to a community-based cross-sectional survey.
METHODS : Thirty patients with hyperevaporative dry eye received F6H8 during a prospective , multicenter , observational 6-week study.
METHODS : Thirty-seven carotid artery disease patients participated in this study , of whom @number@ underwent magnetic resonance imaging before and after CEA.
METHODS : Thirty-seven female office workers were recruited in this study.
METHODS : Thirty-seven long-term care units for residents with dementia in nursing- and residential homes in the Netherlands participated in the study.
METHODS : Thirty-seven members of active retirement groups volunteered to participate and were randomly assigned to a crossword group and a control group.
METHODS : Thirty-six aging adults participating in a multimodal wellness program were evaluated on enrollment and after @number@ months of participation.
Methods : Thirty-six patients with bipolar disorder type @date@ siblings , and @number@ healthy controls were assessed.
METHODS : Thirty-three aged men with symptoms of hypogonadism and testosterone deficiency who had received ART for @number@ months responded to this survey.
Methods : Thirty-three eyes of @number@ RRD patients scheduled for scleral buckle surgery were enrolled in the study.
METHODS : Thirty-three healthy subjects within two age groups ( young , elderly ) were scanned at 3T.
METHODS : Thirty-two elderly patients with SBO received intestinal decompression with a 300-cm long nasointestinal tube inserted into upper jejunum under radiographic control.
METHODS : Thirty-two male subjects voluntarily participated in this study.
METHODS : This 12-year longitudinal study of a community-dwelling population in Japan included @number@ examinations of @number@ men and @number@ women.
METHODS : This 2008-2012 exploratory observational cohort study was conducted with community-dwelling women aged @number@ and over.
METHODS : This analysis included @number@ women and @number@ men age @number@ to @number@ yr.
METHODS : This analysis used data from the Bambuí Cohort Study of Aging.
METHODS : This article is based on a selective review of the literature and on clinical experience.
METHODS : This article is written from the authors ' experience.
METHODS : This article presents one surgeon's concepts of the process that culminate in the typical appearance of the aged upper face.
METHODS : This commentary is based on expert opinion and supplemented with published / presented information identified through PubMed and rheumatology associations.
METHODS : this cross-sectional analysis used data of n = @number@ individuals aged 58-82 from a population-based prospective cohort study.
METHODS : This cross-sectional observational study was conducted among aged outpatients of different accredited community pharmacies across Lebanon.
METHODS : This cross-sectional study examined @number@ subjects of the KORA-Age study.
METHODS : This cross-sectional study included @number@ elderly women , who were @number@ years old or above , in Campinas-SP , Brazil.
METHODS : This cross-sectional study included @number@ older adults aged 60-79 years old.
METHODS : This cross-sectional study included ten apparently healthy people who had been submitted to a protocol on a cycle ergometer for @number@ minutes.
METHODS : This cross-sectional study recruited @number@ older adults ( 60 + years ) in rural South Carolina.
METHODS : This cross-sectional study was conducted in five provinces of Cambodia from May- @date@ .
METHODS : This cross-sectional study was conducted in Liaobu Town , Dongguan city , China.
METHODS : This cross-sectional study was conducted on @number@ middle-aged Korean men.
METHODS : This cross-sectional study was done in @number@ menopausal women @number@ years old or older.
METHODS : This descriptive-analytical study that was conducted in Tabriz City , Iran.
METHODS : This descriptive cross-sectional study was conducted in @number@
METHODS : This door-to-door survey was performed by an Arab-speaking team in Wadi Ara villages in Israel.
METHODS : This double-blinded , placebo-controlled , trial occurred in two phases under ad libitum conditions.
METHODS : This double-blind , randomized controlled trial studied men 55-75 y of age.
METHODS : This index is based equally on both , resources and risks / functional restrictions which precede ADL limitations.
METHODS : This is achieved by a two-stage process.
METHODS : This is a cluster randomised , single-blind , controlled trial where general practitioners are invited to participate with patients from their lists.
METHODS : This is a combined retrospective-prospective cohort study , which includes @number@ community-dwelling older men and women participants.
METHODS : This is a community-based , cross-sectional study involving self-administered questionnaires conducted from @date@ to @date@ .
METHODS : This is a cross-sectional analysis of otherwise well , HIV infected outpatients on ART for > 5 years.
Methods : This is a cross-sectional , observational and analytical household research conducted with a sample of @number@ urban elderly.
METHODS : This is a cross-sectional , population-based single-centre study.
METHODS : This is a cross-sectional population- based study carried out with @number@ elderly residents in two areas of a city in southern Brazil.
METHODS : This is a cross-sectional population-based study in an urban area with a population of over @number@
METHODS : This is a cross-sectional population study of people aged @number@ years and over.
METHODS : this is a cross-sectional study in community-dwelling older adults recruited from residential and retirement communities in Baltimore , MD , USA.
METHODS : This is a cross-sectional study that included @number@ nursing homes across France.
Methods : this is a longitudinal study involving community-dwelling participants aged ≥50 years , using data from The Irish Longitudinal Study on Ageing.
METHODS : This is a longitudinal study of @number@ randomly selected subjects ( mean @number@ years , range 51-80 , @percent@ women ) .
METHODS : This is a multi-centre , prospective , non-interventional observational study carried out in France , Germany , Spain and the United Kingdom.
METHODS : This is a prospective cohort study conducted in @number@ Canadian hospitals.
METHODS : This is a prospective observational cohort study.
METHODS : This is a prospective observational cohort study approved by the regional ethics board.
METHODS : This is a prospective observational study.
METHODS : This is a prospective observational study ( Canadian Task Force @date@ performed in a tertiary referral center.
METHODS : This is a qualitative descriptive study entailing @number@ semi-structured interviews with @number@ carers of patients with ALC from three hospitals in Northwestern Ontario.
METHODS : This is a randomization trial.
METHODS : This is a retrospective analysis of predefined endpoints from an integrated database of seven RCTs of T2DM patients treated with insulin lispro.
METHODS : This is a retrospective cohort study.
METHODS : This is a retrospective cohort study of older patients with SA infections.
METHODS : This is a retrospective cohort study performed in the Amphia Hospital , Breda , the Netherlands.
METHODS : This is a retrospective cross-sectional study.
METHODS : This is a retrospective , cross-sectional study , using the Dutch , nationwide ATHENA observational HIV cohort database.
METHODS : This is a retrospective investigation along with secondary topics from the raw data base.
METHODS : This is a retrospective longitudinal cohort study of all symptomatic patients who underwent CAS in our center between @number@ and @number@
METHODS : This is a retrospective observational study using publicly available Hospital Compare data and Medicare Part A claims data.
METHODS : This is a retrospective study.
METHODS : This is a retrospective study in @number@ patients who had received atlantoaxial fixation according to the Harms method following atlantoaxial injury.
METHODS : This is a retrospective study of @number@ children who had normal echocardiograms.
METHODS : This is a secondary analysis from the SABE @number@ Bogota survey , which is a cross-sectional study.
METHODS : This is a secondary analysis of data from a randomized placebo-controlled trial of @number@ mg / d calcium supplementation to prevent bone loss.
METHODS : This is a secondary analysis of the Health , Aging , and Body Composition Study.
METHODS : This is a secondary analysis of the multisite , randomized trial Advanced Cognitive Training for Independent and Vital Elderly.
METHODS : This is a single-center , prospective , randomized controlled study.
METHODS : This is not a review nor meant to be comprehensive.
METHODS : This nested case-control study was based on @number@ incident HF cases ( of whom @number@ cases had antecedent CHD ) and @number@ controls.
METHODS : This non-interventional prospective observational study was conducted in a geriatric medicine outpatient clinic.
METHODS : This observational retrospective follow-up study included @number@ patients with T1D onset between @number@ and @number@ treated at the Navarre Hospital Complex.
METHODS : this observational study was done in consecutive patients ≥75 years old presenting to the ED.
METHODS : This open-label prospective study assessed older patients naïve to strong opioids presenting with moderate-to-severe chronic pain.
METHODS : This paper examines challenges related to the financial- and organizational sustainability of LTC systems in the EU.
METHODS : This paper presents a conceptual framework for using lifespan developmental theory to better understand late life suicidal behavior.
METHODS : This paper uses data from a national survey of older persons in Thailand conducted in @number@
METHODS : This population-based cross-sectional study is part of the Survey on Health , Well-Being , and Aging ( SABE ) .
METHODS : This population-based longitudinal study included a sample of @number@ adult male twins.
METHODS : This population-based study included @number@ participants ( age ≥60 years , @percent@ women ) free of dementia and stroke.
METHODS : This program was based on low intensity strength and balance exercises , and was carried out with simple , readily available equipment.
METHODS : This prospective cohort study enrolled older men aged @number@ and older living in a Veterans Care Home.
METHODS : This prospective cohort study included @number@ community-dwelling memory clinic patients with dementia , mild cognitive impairment , or no cognitive impairment.
METHODS : This prospective cohort study included @number@ patients , median age @number@ years , that had HFrEF.
METHODS : This prospective , cross-sectional study included patients diagnosed with EE by upper gastrointestinal endoscopy between @date@ and @date@ at @number@ Japanese hospitals.
METHODS : This prospective , non-randomized intervention study was carried out at the department of general internal medicine at a tertiary university hospital.
METHODS : This prospective observational study was conducted at an academic ED in patients aged @number@ years or older.
METHODS : This prospective randomized study enrolled @number@ elderly malnourished or at-risk patients in an inpatient rehabilitation unit.
METHODS : This prospective study analyzed @number@ patients who had completed preconcussion and postconcussion neuropsychological testing within the Washington , DC , area.
METHODS : This qualitative description explored the perceptions of physical activity among older adults living in two rural communities in the Canadian province of Saskatchewan.
METHODS : This qualitative study examined perspectives of IRB members in Botswana about the collection and use of biospecimens in research.
METHODS : This qualitative study was conducted using content analysis.
METHODS : This qualitative study was conducted with representative types of patients suffering from osteoarthritis.
METHODS : This questionnaire translated literally and in culturally relevant form , then content validation process was done by three groups ' experts.
METHODS : This randomized trial aims to recruit @number@ participant dyads of a person with dementia and their caregivers.
METHODS : This register-based study included @number@ patients from the Swedish National Quality Register for ECT.
METHODS : This research consists of two studies.
METHODS : This research was part of the Progetto Veneto Anziani ( Pro.V.A. ) , an Italian population-based cohort study of @number@ elderly subjects.
METHODS : This retrospective cohort study included @number@ PD patients with ≥2 APD prescriptions who initiated a modification of APD regimens in @number@
METHODS : This retrospective cohort study was a substudy of The Longitudinal Older Veterans study.
METHODS : This retrospective cohort study was conducted in an integrated health care delivery system.
METHODS : This retrospective multicenter study enrolled @number@ representative general hospitals from @date@ to @date@ .
METHODS : This retrospective registry study consisted of @number@ persons with late effects of polio living in Sweden.
METHODS : This retrospective study included @number@ eyes of @number@ patients with DED.
METHODS : This retrospective study included @number@ patients undergoing a fresh cycle of oocyte retrieval and day-3 embryo transfer.
METHODS : This review and meta-analysis assembles prospective studies regarding the relation between frailty and any potential health outcome.
METHODS : This review comprised studies published from @number@ to @date@ from the Pubmed database.
METHODS : This screening and treatment service of dermatological diseases was conducted in a Veterans Home in Southern Taiwan.
METHODS : This single-site , randomized , assessor-blinded , controlled trial was conducted from @number@ to @number@
METHODS : This study applied a correlational study design.
METHODS : This study applied exploratory and descriptive qualitative methods and adapted a working life-span framework.
METHODS : This study assessed the effectiveness of the Internet intervention ' Mastery over Dementia'.
METHODS : This study comprised @number@ patients of median age @number@ ( 60-104 ) years with coronary artery disease.
METHODS : This study considers a sample of @number@ women from the Nurses ' Health Study who live in or near Boston , Massachusetts.
METHODS : This study employs a representative survey of American adults , aged 57-84 years , using self-reported and laboratory measures.
METHODS : This study enrolled @number@ Chinese patients without postoperative complications after surgery for gastrointestinal or retroperitoneal tumors.
METHODS : This study enrolled @number@ empty-nest elderly as the study respondents.
METHODS : This study enrolled @number@ gastric cancer patients who underwent totally laparoscopic gastrectomy at Hanyang University Guri Hospital and ASAN Medical Center.
METHODS : This study evaluated CRP variability among adults in the southeastern region of the Ecuadorian Amazon where rates of infectious diseases remain high.
METHODS : This study had a cross-sectional design and was conducted in the ED of an academic medical center.
METHODS : This study included @number@ consecutive patients who had high-risk cardioembolic sources and received thrombolytic treatment.
METHODS : This study included @number@ de novo patients with PD and @number@ age-matched controls.
METHODS : This study included @number@ ED patients above 40-years-of-age.
METHODS : This study included @number@ ESRD patients undergoing dialysis and @number@ healthy volunteers.
METHODS : This study included @number@ eyes from @number@ healthy children and @number@ eyes from @number@ healthy adults.
METHODS : This study included @number@ healthy female volunteers aged 35-55 years with phototype II-IV skin.
METHODS : This study included @number@ healthy subjects and @number@ patients with DPLI treated at the stroke centers of three university hospitals in Korea.
METHODS : This study included @number@ individuals who underwent health screening examinations from @number@ to @number@
METHODS : This study included @number@ ( @number@.1±9.4 y ) subjects.
METHODS : This study included @number@ outpatients who met criteria for probable AD.
METHODS : This study included @number@ patients with heart failure ( @number@ ± @number@ yr ) .
METHODS : This study included @number@ premenopausal and @number@ postmenopausal women.
METHODS : This study included older adults ( n = @number@ mean age @number@ ± @number@ years , @percent@ female ) undergoing inpatient post-acute rehabilitation.
METHODS : This study involved @number@ adults aged @number@ years and older.
Methods : This study is a cross-sectional analysis of performance data gathered between @date@ and @date@ .
METHODS : This study is a secondary analysis of data from a randomized controlled trial with 12-month follow-up on @number@ family caregiver-patient dyads.
METHODS : This study is based on cross-sectional analysis of @number@ community-dwelling seniors from the Montreal Unmet Needs Study ( MUNS ) .
METHODS : This study is based on the European Social Survey , Round @number@ ( 2006-2007 ) , which covers @number@ countries.
METHODS : This study is part of a Geriatric Multidisciplinary Strategy for the Good Care of the Elderly project ( GeMS ) .
METHODS : This study is part of a prospective one-year study conducted on hypertension management in a population aged @number@ to @number@ years.
METHODS : This study is part of the Rotterdam study , a large prospective population-based cohort study among men and women aged 55years and over.
METHODS : This study is the first radio-anatomic study designed to address this topic in children.
METHODS : This study prospectively evaluated a subset of five patients who had deep-plane face lifts with fat injection , and other facial cosmetic procedures.
METHODS : This study randomized @number@ postmenopausal women into either the WBV group or the control group for a 6-month trial.
METHODS : This study reports data from @number@ nursing home residents.
METHODS : this study used a cross-sectional design.
METHODS : This study used a descriptive quantitative method.
METHODS : This study used baseline data ( 2008-2010 ) for @number@ current workers from ELSA-Brasil.
METHODS : This study used cross-sectional analysis of data from the @number@ American Board of Family Medicine Maintenance of Certification Demographic Survey.
METHODS : This study used fMRI to investigate whether age-related differences in language production are associated with transmission deficits or inhibition deficits.
METHODS : This study used @number@ cadaveric lumbar vertebrae from @number@ adult spines at the Hamann-Todd Human Osteological Collection.
METHODS : This study uses data from a cross-sectional survey and a qualitative investigation conducted in Zhejiang province in @number@
METHODS : This study utilized data acquired during the Korean National Health and Nutrition Examination Survey ( KNHANES ) from 2008-2011.
METHODS : This study was a longitudinal assessment of variables drawn from an epidemiological prospective study of women's healthy aging.
METHODS : This study was a prospective analysis of patients ≥65 years old who were undergoing elective coronary angiography for ischemic coronary disease.
METHODS : This study was a retrospective , consecutive , nonrandomized , interventional case series.
METHODS : This study was a review of retrospectively collected data from @number@ spine scoliosis centers belonging to the Japanese Scoliosis Society.
METHODS : This study was a secondary analysis of symptom reports in longitudinal data collected from @number@ PLWH in 1992-1994.
METHODS : This study was a single-center , retrospective cohort study of patients who underwent CRRT from @date@ to @date@ .
METHODS : This study was based on an extensive questionnaire survey.
METHODS : This study was based on combined data from two research projects focusing on the health and well-being of community-dwelling elderly people in Rotterdam.
METHODS : This study was conducted during 2012-2014 in Silver Chain Hospice Care Service in Western Australia.
METHODS : This study was conducted during 2012-2014 in Silver Chain Hospice Care Service in Western Australia.
METHODS : This study was conducted on @number@ French women divided into four groups of age.
METHODS : This study was designed as a quasi-experimental trial with a one-year follow-up.
METHODS : This study was exploratory and used mixed methods.
METHODS : This study was performed in @number@ men with LOH and in @number@ eugonadal control group.
METHODS : This study was performed in @number@ prediabetic men and in @number@ normoglycemic , control group.
METHODS : This study was performed in six consecutive patients who were candidates for face lift and whose ages ranged between @number@ and @number@ years.
METHODS : This systematic review examined the relationships among aspects of personality and HRQOL.
METHODS : This translational study was nested within a cohort study and an exploratory psychophysics study.
METHODS : This was a 6-month randomized crossover trial comparing add-on insulin detemir versus glargine in poorly controlled T2D with macroangiopathy.
METHODS : This was a before-after comparison of the frequency of the recommended starting doses of high-risk medications to adults aged @number@ years and older.
METHODS : This was a case series of @number@ patients injected with large-particle calcium hydroxylapatite.
METHODS : This was a cluster-randomized controlled trial.
METHODS : This was a cohort study with elderly patients ages ≥65 y admitted between September and @date@ .
METHODS : This was a cross-sectional analysis of @number@ patients on hemodialysis for at least one year.
METHODS : This was a cross-sectional analysis using the @number@ National Emergency Department Sample for all treated-and-released visits in persons aged ≥18 years.
METHODS : This was a cross-sectional observational study of individuals aged @number@ years and above.
METHODS : This was a cross-sectional pilot study that included @number@ people over the age of @number@ years.
METHODS : This was a cross-sectional , population-based household survey.
METHODS : This was a cross-sectional postal survey , comprising @number@ twin individuals , representative of the general Danish adult population.
METHODS : This was a cross-sectional study.
METHODS : This was a cross-sectional study.
METHODS : This was a cross-sectional study.
METHODS : This was a cross-sectional study carried out on a single vessel during a summer deployment.
METHODS : This was a cross-sectional study involving @number@ stroke survivors and @number@ age- and sex-matched , apparently healthy controls.
METHODS : This was a cross-sectional study of direct care staff experiencing recent patient death.
METHODS : This was a cross-sectional study of middle-aged individuals ( n = @number@ ) in Tsukuba , Japan.
METHODS : This was a cross-sectional study of @number@ institutionalized elderly in the city of João Pessoa , Brazil.
METHODS : This was a descriptive , observational study of @number@ elderly women aged @number@ or older.
METHODS : This was a family- and cohort-based genetic association study.
METHODS : This was a hospital-based , case-control study of patients aged ≥65 years hospitalized from LTCFs.
METHODS : This was a large-scale , population-based , case-control study.
METHODS : This was a longitudinal cohort study of the Swedish dementia and stroke registries.
METHODS : This was a multicentric prospective cohort study involving @number@ long-term care resident elderly individuals.
METHODS : This was an 8-day diary of @number@ family caregivers of individuals with dementia.
METHODS : This was an ambidirectional cohort study conducted at the University Malaya Medical Centre ( UMMC ) in Kuala Lumpur , Malaysia.
METHODS : This was a nationwide cross-sectional , register-based study across the whole of Sweden in @number@
METHODS : This was a nested case-control study using Long Life Family Study data.
METHODS : This was an exploratory observational study in a sample of @number@ elderly women of mean age @number@ years.
METHODS : This was an observational , cross-sectional , multicenter , spontaneous , non-pharmacological study.
METHODS : This was an observational cross-sectional study of @number@ older people at two inpatient aged care rehabilitation units.
METHODS : This was an observational study of @number@ antiplatelet-related ICH survivors.
METHODS : This was an open-labeled , randomized intervention study.
METHODS : This was a normal value test which enrolled @number@ healthy subjects aging from @number@ to @number@ years old.
METHODS : This was a population-based cohort study conducted between @number@ and @number@ with mortality follow-up through to @number@
METHODS : This was a pragmatic randomized controlled study conducted in primary care.
METHODS : This was a prospective cohort study.
METHODS : This was a prospective cohort study including @number@ @number@ admissions of patients with cancer from @number@ EORTC centers.
METHODS : This was a prospective , cross-sectional study.
METHODS : This was a prospective , double-blind , double-arm , randomized , placebo-controlled trial of MAL plus red light in patients with facial photodamage.
METHODS : This was a prospective population-based cohort study of @number@ dementia-free Italian community dwellers aged @number@ years or older.
METHODS : This was a prospective randomized clinical study in which the variables were assessed before and after the training program.
METHODS : This was a prospective study.
METHODS : This was a prospective study.
METHODS : This was a prospective study across two moments in time.
METHODS : This was a prospective study of @number@ patients undergoing COH at the Fertility and IVF Center at GWU.
METHODS : This was a prospective study that enrolled consecutive patients admitted with an acute ischemic stroke.
METHODS : This was a randomised controlled study in @number@ frail inpatients ( in @number@ ) .
METHODS : This was a randomized controlled trial ( RCT ) in community-dwelling elderly in Japan.
METHODS : This was a retrospective cohort study in a primary care internal medicine practice.
METHODS : This was a retrospective cohort study of @number@ tall women aged 23-48 yr , of whom @number@ women had been treated.
METHODS : This was a retrospective cohort study of patients with COPD attending an outpatient PR program.
METHODS : This was a retrospective single-center study with cases comprising all IBD patients who began anti-TNF treatment at age > 60 years.
METHODS : This was a retrospective study.
METHODS : This was a retrospective study performed over @number@ months in hospital geriatric medicine.
METHODS : This was a retrospective survey at Second Affiliated Hospital of Zhejiang University , which included all consecutive patients between @number@ and @number@
METHODS : This was a secondary analysis of a retrospective cohort of elderly fall patients who presented to the ED from one urban teaching hospital.
METHODS : This was a secondary analysis of cognitive , genetic and alcohol consumption data collected from members of the Framingham Heart Study Offspring Cohort.
METHODS : This was a secondary analysis of cross-sectional survey data collected in @number@ countries taking part in the @number@ WHOQOL-OLD Field study.
METHODS : This was a secondary analysis of the last wave of the Mexican Health and Aging Study.
METHODS : This was a single-center observational study of @number@ Chinese patients with nonvalvular AF from @date@ to @date@ .
METHODS : This was a split-face , randomized and evaluator-blinded comparison study.
METHODS : This was a two-stage cluster-controlled trial carried out in five geriatric rehabilitation wards.
METHODS : Those effects were assessed by semi-quantitative PCR , Western blotting and enzymatic activity assays.
Methods : Thousand five hundred and two participants from the Berlin Aging Study II were included.
METHODS : Three clinical dermatology faculty members selected , discussed , and appraised the main signs of forearm photoaging.
METHODS : Three cognitive tasks ( i.e.
METHODS : Three-dimensional ( 3D ) cardiac reconstructions of the LAA were performed from CT scans of @number@ consecutive patients.
METHODS : Three-dimensional midsystolic mitral valve models were constructed in @number@ children and young adults with normal echocardiograms using 3D transthoracic images.
METHODS : Three hundred and sixty community-dwelling older adults ( aged 60-103 years ) were recruited.
METHODS : Three hundred and six volunteers for ZINCAGE Project recruited.
METHODS : Three hundred and thirty-eight healthy subjects ( @number@ men ; @number@ women ) with no corneal disease underwent an exhaustive ocular examination.
METHODS : Three hundred fourteen older adults from @number@ nursing homes in Korea were included in the study.
METHODS : Three hundred ninety-nine men were included and answered a questionnaire about lifestyle and medical history.
METHODS : Three IOLs of each model with different dioptric powers ( @number@ @number@ and @number@ diopters ) were analyzed.
METHODS : Three patients with PDP were treated with BTX-A for their leonine facies.
Methods : Three thousand one hundred fifty-eight community-dwelling Chinese older adults in the Greater Chicago Area were surveyed.
METHODS : Three thousand three hundred sixty nine community-dwelling men aged 40-79 years were recruited for participation in EMAS.
METHODS : Through a cross-sectional study using randomized cluster sampling , @number@ clusters were selected in Sari , a city in the North of Iran.
METHODS : Through examining effective overseas older adult-specific interventions , in addition to other relevant literature , an early intervention protocol was developed.
METHODS : Through multistage stratified cluster random sampling methods , residents aged @number@ years and above were selected.
METHODS : Through the Healthy Aging Regional Collaborative , @number@ area agencies delivered @number@ workshops in @number@ locations throughout South Florida.
METHODS : thyroid function parameters were measured in the frame of a comprehensive geriatric assessment.
METHODS : To address these questions , we conducted a longitudinal MRI study to investigate the gray matter ( GM ) changes in AD progression.
METHODS : To assess the performance of the method , we arranged a follow-up study of four acute wounds.
METHODS : To better understand the cause of age-associated changes in the perioral area , a cadaver dissection study was performed.
METHODS : To determine the optimal conditions , we transplanted different concentrations of BMSCs at different time points in a rat model of ischemic stroke.
Methods to estimate energy requirements have not been devised for this patient group.
METHODS : To identify reliable and constant landmarks of the ongoing process of perioral aging , @number@ perioral photo documentations were morphometrically analyzed.
METHODS : To identify the best nongenetic predictors of survival in centenarians , we examined @number@ individuals aged 100 + years.
METHODS : To investigate neurocognitive outcomes , @number@ survivors of childhood cancer underwent unenhanced screening MRI of the brain.
METHODS : Total and differential WBC counts were examined at a baseline examination from @number@ to @number@ in the Honolulu Heart Program.
METHODS : Total fluorescent advanced glycation end-products ( AGEs ) were measured in @number@ human cortical bone samples from @number@ donors.
METHODS : Totally @number@ Hong Kong Chinese with T2DM were recruited during 1994-1996 and followed up until @date@ .
METHODS : Total @number@ aged @number@ years and over participated in a baseline study.
METHODS : Toxin-naive women ( N = 45 ) aged @number@ to @number@ with moderate to severe glabellar lines at maximum contraction completed the study.
METHODS : Transcriptional activity of CpG was assessed using gene expression data and DNA methylation data for preserved and lesional articular cartilage samples.
METHODS : Transduced PTD-EGF and FGF1 proteins were detected by immunofluorescence and immunohistochemistry.
METHODS : Transplant outcomes were evaluated according to the sum of the A alleles in the recipients and the donors.
METHODS : Transthoracic echocardiograms were acquired in @number@ healthy subjects ( @number@ children , @number@ young adults ) and were retrospectively analyzed.
METHOD : Straw drinking speed in a normal healthy population of @number@ adults from @number@ to @number@ years of age was measured.
METHODS : TRX1 and TRX80 plasma levels were determined with a specific ELISA.
METHODS : TSH , free T₄ , and free T₃ ( FT₃ ) were measured on the first day of admission.
METHODS : TSH was measured by a sensitive immunofluorometric assay.
METHOD : Study @number@ drew on a community-based sample of @number@ participants.
METHOD : Study observational , descriptive , cross-sectional of @number@ adults with @number@ to @number@ years , was used a instrument of feeding behavior.
METHODS : Twelve community-dwelling adults ( 70 + ) were recruited in a multiple-case study design.
METHODS : Twelve healthy women aged 20-59 years with periorbital wrinkles participated in this study.
METHODS : Twelve patients with FMEC aging from @number@ months to @number@ years were treated by single-stage combined craniofacial approach between @date@ and @date@ .
METHODS : Twenty community-dwelling older adults ( @number@ ± @number@ ) volunteered to have their muscular power assessed during repeated sit-to-stand ( STS ) tasks.
METHODS : Twenty-eight thousand one hundred ninety-two patients who underwent colonoscopy at an emergency hospital were reviewed from an electronic endoscopy database.
METHODS : Twenty-eight women , aged @number@ to @number@ years , completed the 6-month intervention study.
METHODS : Twenty-five participants with aMCI , @number@ AD patients , and @number@ healthy elderly participants underwent testing of olfactory identification.
METHODS : Twenty-five women were analysed with regard to wrinkle parameters and mottled pigmentation on the face.
METHODS : Twenty-four fresh-frozen gluteus medius specimens were obtained through a posterolateral approach to the hip.
METHODS : Twenty-four subjects aged @number@ to @number@ years underwent laser lipolysis of the submental and anterior cervical areas.
METHODS : Twenty healthy , elderly adults ( @number@ women and @number@ men ; mean age @number@ ± @number@ years ) participated in this study.
METHODS : Twenty healthy older adults were assigned to either training or control groups.
METHODS : Twenty intubated infants [ aged 39-77 weeks post-menstrual age ( PMA ) ] were studied after surgery during sevoflurane wash-out.
METHODS : Twenty male patients undergoing subtotal gastrectomy were enrolled in this study.
METHODS : Twenty-nine healthy subjects , @number@ younger ( mean age : @number@.8years ) and @number@ senior ( @number@ years ) , participated.
METHODS : Twenty-nine untreated girls with Class II malocclusion were identified among participants of the Nijmegen Growth Study.
METHODS : Twenty older adults and @number@ younger adults were assessed.
METHODS : Twenty-one adults aged @number@ years and older were randomised into one of two groups.
METHODS : Twenty one and @number@ subjects completed a 12-week MCT and RT program respectively.
METHODS : Twenty-one healthy subjects ( aged 20-65 years ) were recruited for gait analysis.
METHODS : Twenty-one pre-presbyopic volunteers ( aged @number@ ± @number@ years ) participated in the study.
METHODS : Twenty participants with and @number@ without CLBP participated in the study.
METHODS : Twenty patients diagnosed with CBS were investigated , according to the diagnostic criteria established by Gold and Rabins and Teunisse.
METHODS : Twenty patients ( mean age @number@ years ) with photodamaged skin were focally treated on dorsal forearms with a nonablative fractionated laser.
METHODS : Twenty patients received five treatments each at 3-week intervals.
METHODS : Twenty-six elderly cataract patients scheduled for binocular cataract surgery and @number@ elderly volunteers without cataract were enrolled in the study.
Methods : : Twenty-six euthymic subjects with BD and @number@ healthy controls were recruited.
METHODS : Twenty-six female patients were included in our study with ages between @number@ and @number@
METHODS : Twenty-six male runners training for the @number@ Olympics were recruited.
METHODS : Twenty-three female subjects used the STOP at home for a period of @number@ weeks followed by a maintenance period of @number@ weeks.
METHODS : Twenty-three GPs from England were interviewed by telephone.
METHODS : Twenty-three graduates of NP program options at two universities in the western U.S. participated in focus group discussions or interviews.
METHODS : Twenty-three healthy young adults ( @number@.9±3.7yrs ) and @number@ healthy older adults ( @number@.7±5.8yrs ) participated in this study.
METHODS : Twenty-two children were included in this study.
METHODS : Twenty-two euthymic female patients with BD type I and @number@ age-matched healthy controls were selected for the study.
METHODS : Twenty-two female and @number@ male patients older than @number@ years were enrolled.
METHODS : Twenty-two participants were randomly assigned to experimental or control conditions.
METHODS : Twenty-two patient-caregiver dyads were enrolled : Thirteen behavioral variant FTD ( bvFTD ) and nine semantic dementia ( SD ) .
METHODS : Twenty-two subjects received injections of HA filler into the NLFs.
METHODS : Two authors independently searched PubMed , Cochrane , and Google Scholar data-bases between @date@ and @date@ .
METHODS : Two authors searched major electronic databases from inception until @date@ for cross-sectional / longitudinal studies investigating depression and frailty.
METHODS : Two-center open-label , 14-day study in toxin-naive female patients with moderate-to-severe glabellar lines ( GL ) treated with 20-U onabotulinumtoxinA.
METHODS : Two cohorts of women aged @number@ to @number@ years and @number@ to @number@ years were photographed to determine eyebrow position.
METHODS : Two data sets were used : at the client and home-care site levels.
METHODS : Two double-blind , 10-week ( 2-week washout + 8-week treatment ) , left-right randomized , split-face clinical studies were conducted.
METHODS : Two experiments were conducted on both younger and older adults.
METHODS : Two forward translations , a reconciled version , and then a back translation were completed and subjected to expert review.
METHODS : Two hundred and fifty-nine children carrying an FBN1 gene mutation and fulfilling Ghent criteria were compared with @number@ non-Marfan syndrome children.
METHODS : Two hundred and forty-eight healthy female volunteers , aged between @number@ and @number@ years , were chosen for this study.
Methods : Two hundred and nine elderly hip-fracture patients who had undergone hemiarthroplasty and had completed our assessments were selected.
METHODS : Two hundred and twelve eyes of @number@ participants with no ocular pathology had CH and CRF measured with the ORA.
METHODS : Two hundred and twenty-eight subjects who lived in Sanya , China , were involved.
METHODS : Two hundred and two patients with mild memory problems were recruited.
METHODS : Two hundred fifty healthy volunteers were enrolled.
METHODS : Two hundred fifty-three subjects participated in this observational cross-sectional multicenter study.
METHODS : Two-hundred ninety healthy adults provided information on childhood parental loss and maltreatment and completed diagnostic interviews.
METHODS : Two hundred seventeen patients with single-level osteoporotic vertebral fractures with intravertebral cleft were examined.
METHODS : Two hundred thirty-eight eyes ( @number@ subjects ) with no ocular disease were included.
METHODS : Two hundred twelve consecutive patients with pathologically confirmed AD or FTLD who were clinically assessed in a specialist cognitive unit were identified.
METHODS : Two investigators recorded CMAP scans in ten healthy subjects , each on two different days.
METHODS : Two iPSC-MSC lines ( named as mRNA-iPSC-MSC-YL001 and lenti-iPSC-MSC-A001 ) and one BM-MSC line were used for the study.
METHODS : Two large families with multiple affected members were recruited.
METHODS : Two large international registries ( Zygomyco.net and FungiScope™ ) were searched for mucormycosis cases in ≤19 year-old patients.
METHODS : Two patient groups participated in face-to-face qualitative interviews.
METHODS : Two sample populations were studied.
METHODS : Two samples of elderly patients ( aged 65 + years ) hospitalized in a geriatric ward in Italy were enrolled throughout @number@
METHODS : Two samples of institutionalized people aged @number@ and over were analysed together : @number@ older adults without dementia and @number@ with dementia.
METHODS : Two study populations , middle-aged experienced drummers and a younger novice group participated in 40-min djembe drumming sessions.
METHODS : TXS and VEGF metabolite levels were measured in NSCLC serum samples ( n = 46 ) by EIA.
METHOD : Subjects included @number@ patients with neurodegenerative disease.
METHODS : Uma Jeunesse® is crosslinked with butanediol diglycidyl ether ( BDDE ) using a new crosslinking technology.
METHODS : Using a cross-sectional research design , data were collected once from @number@ elderly ( mean age @number@ years ) .
METHODS : Using a cross-sectional study of TB surveillance data , we analyzed @number@ TB cases reported in Michigan during 2004-2012.
METHODS : Using a multi-stage cluster sampling approach , a cross-sectional survey of @number@ elderly house-dwelling residents was conducted in Shanghai , China.
METHODS : Using computerized randomly selection , a representative sample of @number@ 75-year-olds living in Tehran ( 2007-2008 ) , Iran , was included.
METHODS : Using data from the Korean Longitudinal Study of Ageing , @number@ females and @number@ males were analyzed separately.
METHODS : Using data from the MADIABETES Study we conducted a retrospective case record form based study without controls.
METHODS : Using linked Surveillance , Epidemiology , and End Results-Medicare data , we identified @number@ men diagnosed with prostate cancer from @number@ to @number@
METHODS : Using PubMed , we identified randomized trials involving KTRs from @number@ to @number@ and determined age-exclusion criteria and the mean age of participants.
METHODS : Using quantitative questionnaires , general practitioners prospectively evaluated their own investigation and treatment of osteoporosis in patients aged more than @number@ years.
METHODS : Using records from the Danish National Patient Registry ( 1998-2006 ) , we identified @number@ Danish patients with a diagnosis of epilepsy.
METHODS : Using Sanger sequencing we identify a heterozygous splice-site mutation in FLCN in lymphocyte DNA of a patient suffering from renal cell carcinoma.
METHODS : Using Taiwan's National Health Insurance Research Database , we identified @number@ people with dementia that died between @number@ and @number@
METHODS : Using the hospital's electronic database , @number@ patients who underwent a shoulder CT scan were randomly selected retrospectively.
METHODS : UVA-induced metalloproteinase-1 ( MMP-1 ) expression in dermal fibroblast was used as a model system for investigation.
METHODS : Variables known to predict progression in MCI patients and hypothesized to predict progression in early-stage MCI patients were selected.
METHODS : Vascular smooth muscle cells ( VSMC ) were obtained from patients undergoing abdominal surgery.
METHODS : VCs were measured in DMD.
METHODS : Vestibular ganglion cells , spiral ganglion cells , and cochlear hair cells were counted in specimens from individuals with presbycusis and normal hearing.
METHODS : Voice acoustic and phonetogram parameters were determined for the group of @number@ singing and @number@ non-singing children.
METHODS : Volunteer elderly people ( @number@ ) were included the study.
METHODS : Volunteers and patients were measured by SIAscopy at six spots on sun-exposed and two spots on sun-protected skin.
METHODS : Volunteers were exposed to repetitive solar-simulated ( ss ) UVR at @number@ times minimal erythema dose for four consecutive days.
METHODS : VOR gain deficit and compensatory saccades were measured with vHIT.
METHODS : Wave @number@ subjects underwent an active stand with non-invasive beat-to-beat blood pressure monitoring.
METHODS : We address this issue by comparing hypertension and control-performers in a functional MRI study.
METHODS : We administered a neuropsychological battery to PD participants in the Michael J. Fox Foundation AJ consortium.
METHODS : We adopted a case study design and included a sample of five patients.
METHODS : We adopted a transversal descriptive epidemiological study.
METHODS : We analysed data from adults interviewed for the @number@ English National Psychiatric Morbidity Survey , representative of people living in private homes.
METHODS : We analysed data from a subsample of the Australian Diabetes , Obesity and Lifestyle study ( AusDiab ) cohort.
METHODS : We analysed data from @number@ persons aged @number@ years and over who participated in the @number@ National Health Interview Survey.
METHODS : We analysed data from the NANA validation study using a machine learning approach.
METHODS : We analysed data of @number@ older patients , aged 65years or older , consecutively admitted to seven acute care wards.
METHODS : we analysed prospectively collected data from the Hertfordshire Cohort Study ( HCS ) .
METHODS : We analysed simple sentences spoken by older adults with and without AD.
METHODS : We analysed the educational attainment of participants using The Irish Longitudinal Study of Ageing ( TILDA ) .
METHODS : We analysed the levels of 25-hydroxyvitamin D₃ ( 25 ( OH ) D₃ ) at baseline.
METHODS : We analyzed and reclassified forehead wrinkle types in @number@ recruited healthy individuals.
METHODS : We analyzed community-based cross-sectional data of @number@ older Chinese individuals aged @number@ years or older who participated in the Weitang Geriatric Diseases study.
METHODS : We analyzed cross-sectional data from @number@ adults and @number@ adolescents in the Korean National Health and Nutrition Examination Survey 2010-2012.
METHODS : We analyzed cross-sectional data of @number@ ( @percent@ female ; 69±3.7 years ) old community-dwelling subjects of the Berlin Aging Study II.
METHODS : We analyzed data from a single-blinded , parallel group randomized trial ( ClinicalTrials.gov : NCT01072500 ) .
METHODS : We analyzed data from @number@ community-living Chinese elderly in the Singapore Longitudinal Aging Study ( SLAS ) cohort.
METHODS : We analyzed data from @number@ consecutive patients with stage III cutaneous melanoma who were treated between @number@ and @number@ at one institution.
METHODS : We analyzed data from @number@ ICD implantation procedures between @date@ , and @date@ in the registry.
METHODS : We analyzed data from our single-center registry on @number@ consecutive patients between @date@ and @date@ .
METHODS : We analyzed data from the American Academy of Family Physicians ' METRIC® PI-CME activity in a cohort of family physician learners.
METHODS : We analyzed data from the Korea National Health and Nutrition Examination Surveys ( 2008-2010 ) .
METHODS : We analyzed data from the @number@ and @number@ waves of the Health and Retirement Study.
METHODS : We analyzed data from the third to fifth waves of Korean National Health and Nutrition Examination Survey ( 2005-2011 ) .
METHODS : We analyzed data on @number@ adults aged @number@ to @number@ years from the Sacramento Area Latino Study on Aging.
METHODS : We analyzed @number@ baseline and @number@ follow-up data from the Mexican Health and Aging Study.
Methods : We analyzed @number@ older adults from the Three-City-Alienor population-based study.
METHODS : We analyzed photographs and examination findings of @number@ patients older than @number@ years who had consultations for lower eyelid blepharoplasty.
METHODS : We analyzed SIRT1 expression in doxorubicin-induced neonatal rat cardiomyocyte injury model and adult mouse heart failure model.
METHODS : We analyzed the hand-drawn spirals of @number@ individuals enrolled in a genetics study at Columbia University Medical Center.
METHODS : We analyzed the medicine of elderly patients in long-term care institutions.
METHODS : We analyzed the @number@ and @number@ datasets of the Taiwan Longitudinal Survey on Aging ( TLSA ) .
METHODS : We analyzed the reduced and oxidized albumin fractions in @number@ patients.
Methods : We applied a mixed-method research design.
METHODS : We applied our approach in an epidemiological study and scaled the composite to a nationally representative sample of older adults.
METHODS : We applied single-nucleotide polymorphism ( SNP ) genotyping to determine whether structural variation causes spinocerebellar ataxia in a family from France.
METHODS : We apply our novel thickness network ( ThickNet ) features to discriminate md-aMCI from healthy controls ( NC ) .
METHODS : We assessed BMD and body composition in @number@ Korean girls with precocious puberty before and after @number@ year of treatment with GnRH agonist.
METHODS : We assessed @number@ patients who underwent hepatectomy at our institute between @number@ and @number@
METHODS : We calculated the predictors of incidence of CSDS over @number@ years of follow-up by the Cox proportional regression analysis.
METHODS : We carried out a cross-sectional study with101 premenopausal and @number@ postmenopausal women from Mexico City.
METHODS : We carried out a prospective analysis involving @number@ men and women aged @number@ years or older from the English Longitudinal Study of Ageing.
METHODS : We collected information on @number@ long-stay nursing home residents from two facilities who fell at least once between @date@ and @date@ .
METHODS : We collected @number@ cadaveric distal humeri with an average age of @number@ years.
METHODS : We collected skin aging and genotype data in @number@ female Han Chinese from the Taizhou cohort.
METHODS : We compared amyloid deposition in autopsied cases aged @number@ years and older who died between @number@ and @number@
METHODS : We compared autopsy-confirmed FTLD and definite AD with Clinical Dementia Rating ≤1.
METHODS : We compared DNAm age between HIV-positive and HIV-negative groups at baseline and between HIV-positive patients at baseline and follow-up.
METHODS : We compared @number@ PVT patients with @number@ healthy subjects and @number@ HCC patients.
METHODS : We compared safety , effectiveness , and persistence of treatment in FTC / TDF versus non-FTC / TDF users.
METHODS : We compared two application methods of ASC : transwell and conditioned medium culture with photo-aged fibroblasts.
METHODS : We conducted a 3-month randomized , waitlist-controlled trial in a volunteer sample of @number@ inactive adults aged 60-70 years without diabetes.
METHODS : We conducted a case-control study ( case : control matching ≈ 1 : 2 ) .
METHODS : We conducted a community-based prospective cohort study.
METHODS : We conducted a community-based prospective cohort study which included @number@ ( @number@ men and @number@ women ) older Korean adults aged ≥65 years.
METHODS : we conducted a comprehensive study on clinical features and mtDNA of @number@ colorectal cancer patients in the Wenzhou area of China.
METHODS : We conducted a cross-sectional analysis of electronic data from the prospective Modena HIV Metabolic Clinic Cohort Study.
METHODS : We conducted a cross-sectional analysis of @number@ healthy US women in the Women's Lifestyle Validation Study , @number@ to @number@
METHODS : We conducted a cross-sectional analysis of the Veterans Aging Cohort Study.
METHODS : We conducted a cross-sectional and analytical study.
METHODS : We conducted a cross sectional , multicenter study that included six nursing homes.
METHODS : We conducted a cross-sectional study comparing quality of life in older persons with and without apathy in @number@ Dutch general practices.
METHODS : We conducted a cross-sectional study in a community-based rural elderly population of Beijing , China.
METHODS : We conducted a cross-sectional study of @number@ Japanese men aged 60-69 years who underwent an annual health check-up.
METHODS : We conducted a cross-sectional study of @number@ men aged 40-89 years undergoing general health check-ups.
METHODS : We conducted a cross-sectional study of @number@ participants from the study Healthy Aging in Neighborhoods of Diversity across the Life Span.
METHODS : We conducted a cross-sectional study of outpatients ( n = @number@ ) in a memory clinic.
METHODS : We conducted a cross-sectional study using a health administrative cohort of @number@ long-term care home residents residing in @number@ Ontario long-term care homes.
METHODS : We conducted a cross-sectional study using questionnaires in young men.
METHODS : We conducted a cross-sectional survey in @number@ NHs in Tuscany , Italy.
METHODS : We conducted a door-to-door survey with multistage probability random sampling.
METHODS : We conducted a double-blind , randomized , placebo-controlled trial in Cuernavaca , Mexico.
METHODS : We conducted a health survey between @number@ and @number@ and @number@ participants ≥ @number@ years old had reliable spirometry.
METHODS : We conducted a literature search in @date@ .
METHODS : We conducted a meta-analysis of @number@ studies obtained through a PubMed literature search.
METHODS : We conducted an analysis of the Clarity Cohort , which is a cross-sectional study of @number@ community-dwelling Irish adults.
METHODS : We conducted a national population-based cross-sectional study with a sample of @number@ men and women aged @number@ years or older in South Africa.
METHODS : We conducted a nationwide retrospective cohort study of older adults who died with ALS in Sweden between @number@ and @number@
METHODS : We conducted a nationwide study by using data from the Taiwan Longitudinal Study on Aging database.
METHODS : We conducted an individual participant data meta-analysis of @number@ observational studies.
METHODS : We conducted an in vitro study using neonatal plasma derived from the placenta / cord units from @number@ term , elective cesarean deliveries.
METHODS : We conducted a non-interventional observational clinical study.
METHODS : We conducted a Phase @number@ prospective , multicenter , randomized , double-blind feasibility trial.
METHODS : We conducted a population-based prospective study as a part of the Korean Longitudinal Study on Health and Aging.
METHODS : We conducted a pre-specified analysis of a randomized double-blind , placebo-controlled trial at a tertiary referral center.
METHODS : We conducted a prevalence-based cost-of-illness study with a societal perspective.
METHODS : We conducted a prospective cohort study among patients with delirium superimposed on dementia who were admitted to a rehabilitation ward.
METHODS : We conducted a prospective cohort study of @number@ Japanese elderly persons aged ≥70 years as a comprehensive geriatric assessment in @number@
METHODS : We conducted a prospective cross-sectional study at the Royal Hobart and Launceston General Hospitals in Tasmania , Australia.
METHODS : We conducted a prospective , multicenter observational study in @number@ ICUs during a 5-week period between @date@ and @date@ .
METHODS : We conducted a prospective , observational , predefined sub-study within the FINNish Acute Kidney Injury ( FINNAKI ) study.
METHODS : We conducted a prospective , randomized controlled trial with @number@ participants aged @number@ years and older.
METHODS : We conducted a prospective study.
METHODS : We conducted a prospective study in @number@ consecutive patients aged @number@ years and over , converted from fluindione to warfarin.
METHODS : We conducted a randomized and double-mask trial of @number@ months duration.
METHODS : We conducted a randomized controlled trial for patients with periorbital wrinkles ( crow's feet ) ( n = @number@ ) .
METHODS : We conducted a retrospective analysis of LTRs in a single institution.
METHODS : We conducted a retrospective analysis of Medicare data from @number@ to @number@ linked to the Minimum Data Set.
METHODS : We conducted a retrospective analysis of protocols of blunt trauma victims aged over @number@ years.
METHODS : we conducted a retrospective chart review of patients undergoing surgery for ovarian cancer in our institution from @date@ to @date@ .
METHODS : We conducted a retrospective cohort study of fee-for-service Medicare beneficiaries with an identifiable PCP who were hospitalized for COPD between @number@ and @number@
METHODS : We conducted a secondary analysis of a multi-institutional prospective cohort study of patients age ≥65 years treated with chemotherapy.
METHODS : We conducted a secondary analysis of a prospective longitudinal study of eight hospitals in St. Louis , MO , USA.
METHODS : We conducted a secondary analysis of @number@ adults cared for in a sobering center from @date@ to @date@ .
METHODS : We conducted a sociometric survey of senior leaders in @number@ long-term care facilities operating in @number@ of Canada's @number@ provinces and territories.
METHODS : We conducted a survey of pregnant women in the province of Quebec ( Canada ) using a Web panel.
METHODS : We conducted a systematic qualitative review of clinical trials that assessed calcitriol for the treatment of osteoporosis and bone loss.
METHODS : We conducted a systematic review and meta-analysis of longitudinal studies examining the associations of PA with HA.
METHODS : We conducted a systematic review of the excess risk of incident dementia conferred by stroke.
METHODS : We conducted a systematic review using the Cochrane Collaboration protocol.
METHODS : We conducted a systematic search of Medline , EMBASE , and Global Health for studies on asthma published between @number@ and @number@
METHODS : We conducted cross-sectional analyses of college students ( n = @number@ ) enrolled in a large southern state university in October of @number@
METHODS : We conducted four focus groups with @number@ participants each.
METHODS : We conducted in-depth telephone interviews with women aged ≥65 years with clinically confirmed osteoporosis.
METHODS : We conducted @number@ English / Spanish focus groups with participants from a Veterans Affairs and county hospital and the community.
METHODS : We conducted @number@ in-depth interviews with adults with SCI ( ten in the US and ten in the UK ) .
METHODS : We conducted qualitative interviews with @number@ CHC staff members representing @number@ CIs across Ontario.
METHODS : We conducted secondary analyses using data from the first two waves of SHARE.
METHODS : We conducted semistructured telephone interviews with @number@ individuals representing @number@ hospice providers across the country.
METHODS : We conducted six focus groups.
Methods : We conducted six focus groups among Chinese-speaking adult women aged @number@ and older.
METHODS : We conducted three focus groups with @number@ current members of an MBSR program.
METHODS : We conducted two cross-sectional surveys of Chinese adults aged ≥60 years in @number@ and @number@
METHODS : We considered how differences in diagnostic criteria may have contributed to these differences in AD prevalence.
METHODS : We constructed three high-resolution human head models representing young , elder , and MCI subjects and modeled two electrode configurations using rectangular electrodes.
METHODS : We describe a method to determine correlations in ( @number@ ) F-FDG spatial distribution over time.
METHODS : We describe the protocol of the Macular Degeneration and Aging Study , a randomized clinical trial of a psychosocial Preventive Problem-Solving Intervention.
METHODS : We designed a multidisciplinary , community-based , prospective longitudinal epidemiologic study among socioeconomically diverse African Americans and Whites.
METHODS : We designed a new paradigm that strictly controlled for perceptual load by presenting the same number of stimuli in each of three conditions.
METHODS : We designed a prospective , multicenter , randomized open label trial to study the effect of bosentan in Fontan patients.
METHODS : We determined foot sensation in @number@ healthy individuals.
METHODS : We determined the impact of leg BFR during walking on cardiovascular function in @number@ young ( @number@ ± @number@ yr ) healthy volunteers.
METHODS : We developed an age cohort model to compute vaccination coverage over time.
METHODS : We developed a yeast model for full-length LRRK2 studies.
METHODS : We developed the mouse-Age Phenotype Knowledgebase , which holds knowledge about age-related phenotypic patterns in mice.
METHODS : We did a genome-wide association study of Finnish patients with ALS and control individuals by use of Illumina genome-wide genotyping arrays.
METHODS : We discuss the concept of personalized medicine and review existing evidence of variability in response to exercise training.
METHODS : We documented @number@ features of microvascular pathologies in spinal cord and brain specimens from @number@ deceased older participants.
METHODS : We employed pooled cross-sectional time series analysis.
METHODS : We enrolled independent community-dwelling adults aged ≥65 years.
METHODS : We enrolled @number@ CLD ( @number@ with naïve hepatocellular carcinoma ) and @number@ normal control subjects ( NCs ) .
METHODS : We enrolled @number@ consecutive patients diagnosed with STEMI involving the inferior wall ; of these , @number@ patients had CAVB.
METHODS : We enrolled @number@ healthy Japanese men.
METHODS : We enrolled @number@ Korean volunteers of various ages who had no hair diseases.
METHODS : We enrolled @number@ males and @number@ females between the ages of @number@ and @number@
METHODS : We enrolled @number@ older adults ( 60-69 years old ) and @number@ young adults ( 20-29 years old ) .
METHODS : We enrolled @number@ participants aged 65 + , derived from the InCHIANTI study , and followed for @number@ years.
METHODS : We enrolled @number@ patients admitted to the Hemodialysis Unit of the Catholic University , Rome.
METHODS : We enrolled @number@ patients with newly diagnosed mild to moderate OSA and @number@ without OSA.
METHODS : We enrolled @number@ patients with uncontrolled asthma who were inhaled corticosteroid-naive.
METHODS : We enrolled @number@ postmenopausal women who had a T score of @number@ to @number@ at the total hip or femoral neck.
Methods : We enrolled patients aged ≥65 years who underwent surgery for localized soft-tissue sarcoma at five institutions.
METHODS : We entered the search terms schizophrenia and MMSE in PubMed and PsychInfo.
METHODS : We estimated ADMI from seafood using the 30-day fish consumption data from the NHANES 2011-2014 datasets.
METHODS : We estimated the frequency of late-life depression within a household community sample of @number@ subjects aged @number@ years or greater with associated factors.
METHODS : We estimated the overall cost of heart failure in @number@ in both direct and indirect terms , across the globe.
METHODS : We estimated values of dietary AGEs using values in a published paper.
METHODS : We evaluated clinical progression in a sample of @number@ older adults with dMCI.
METHODS : We evaluated interhemispheric coherence for the alpha band in @number@ cognitively normal individuals aged @number@ to @number@ years.
METHODS : We evaluated @number@ adult CABG surgery patients.
METHODS : We evaluated @number@ eyes of patients aged between @number@ and @number@ years : @number@ men , @number@ women.
METHODS : We evaluated @number@ patients ( @number@ knees ) who were undergoing bilateral TKA performed by a single surgeon.
METHODS : We evaluated patients with CHF with an ejection fraction ( EF ) of < 50% in this observational cross-sectional study.
METHODS : We evaluated the effect of PlGF on hDPCs and on ex vivo hair organ culture.
METHODS : We evaluated the relationship between leukocyte telomere length and age at natural menopause in @number@ white women ≥65 years of age.
METHODS : We examined age-related alteration of SDPTG ( study @number@ ) and the SDPTG response to a vasodilator ( study @number@ ) .
METHODS : We examined a representative sample of @number@ prime-time advertisements broadcast for a period of @number@ weeks in @number@ in Germany.
METHODS : We examined Medicare beneficiaries with COPD who received oxygen from @number@ to @number@
METHODS : We examined MRI scans from patients with schizophrenia , other psychotic disorders or bipolar disorder and healthy controls using FreeSurfer.
METHODS : We examined national Rehabilitation Services Administration data ( @number@ @number@ ) , including case closure , service outcomes and other demographics.
METHODS : We examined @number@ consecutive patients ( @number@ controls , @number@ with MCI , and @number@ with dementia ) .
METHODS : We examined @number@ healthy men , inhabitants of Wroclaw , aged 32-79 , without any significant medical history.
METHODS : We examined @number@ participants , 65-84 years old , enrolled in the Israel Diabetes and Cognitive Decline study.
METHODS : We examined @number@ patients with de novo PD and @number@ healthy subjects and the differences in hs-CRP between these groups were investigated.
METHODS : We examined @number@ patients with newly diagnosed AD and @number@ healthy controls , and the differences in hs-CRP between these groups were investigated.
METHODS : We examined @number@ women ≥ @number@ years from the InCHIANTI study.
METHODS : We examined relationships between serum TTR and a range of risk factors for mortality in @number@ free-living elderly women.
METHODS : We examined the association between the ALDH2 2 allele and lung function parameters in a population of healthy individuals.
METHODS : We examined the one-year naturalistic course of depressive symptoms in older adult Chinese primary care patients ( Hangzhou , China ) .
METHODS : We examined the potential effect of @number@ different calcium channel modulators on intracellular calcium concentration in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells.
METHODS : We extracted the mtDNA from living subjects residing in Atenas , Costa Rica.
Methods We extracted two cohorts from the Danish Work Environment Cohort Study ( DWECS ) : the 2000-2005 and 2005-2010 cohorts.
METHODS : We first non-invasively measured wrinkle widths with a skin analyzer in a cross-section of @number@ healthy adult Japanese women.
METHODS : We first provide a software tool to systematically identify and characterize genomic regions where low association P-values are observed with multiple traits.
METHODS : We fit latent-class trajectory models of disablement using data from the Health and Retirement Study.
METHODS : We fit linear regression models to examine associations between air pollutants and 8-OHdG adjusting for potential confounders.
METHODS : We focus on the problem of the relationship between AD and IWL , and on which comes first.
METHODS : We followed a discovery-validation strategy to identify sex- and age-related transcriptional differences in lung.
METHODS : We followed @number@ healthy subjects from a cohort of community-dwelling persons aged @number@ years and over ( ESPRIT Project ) .
METHODS : We followed @number@ nursing home residents for @number@ months.
METHODS : We gave a questionnaire to attendants of the courses for BLS or safe driving in authorised driving schools.
METHODS : We have performed a multilevel ordered analysis on the fifth wave of the European Social Survey ( ESS @number@ ) .
METHODS : We here present the design and the preliminary baseline characteristics of the Hellenic Longitudinal Investigation of Aging and Diet ( HELIAD ) .
METHODS : We identified @number@ adult patients from the California Cancer Registry with glioblastoma.
METHODS : We identified @number@ patients from four cohorts of NMO / NMOSD in France , Germany , Turkey and UK.
METHODS : We identified @number@ patients with bone sarcomas using the BSTT Registry during 2006-2012.
METHODS : We identified @number@ patients with schizophrenia starting an antipsychotic that had not used @number@ in the prior year.
METHODS : We identified trajectories of body mass index ( BMI ) development in early life and investigated their mortality risk.
METHODS : Weight and height were measured from age @number@ across a 33-year follow-up.
METHODS : We included CP patients who had undergone whole-spine radiography more than twice and were followed for at least @number@ year.
METHODS : We included echocardiograms done in our institution between @number@ and @number@ for which data on diastolic function were available.
METHODS : We included @number@ consecutive patients with severe aortic stenosis who have undergone TAVI.
METHODS : We included @number@ Normative Aging Study participants with 1-4 BTL measurements from @number@ to @number@
METHODS : We included @number@ older adults ( mean age @number@ ± @number@ years ; @percent@ men ) .
METHODS : We included @number@ participants from the Cooper Center Longitudinal Study who survived to receive Medicare coverage , from @number@ to @number@
METHODS : We included @number@ patients ( ≥65 years ) , hospitalized following admission to the emergency department.
METHODS : We included @number@ patients with first-ever acute ischemic stroke assessed at Hospital del Mar ( Barcelona , Spain ) as the discovery cohort.
METHODS : We included patients with schizophrenia @number@ years or older who were antipsychotic-free for at least @number@ months.
METHODS : We included randomized controlled trials comparing Choto-san with placebo for patients with dementia or mild cognitive impairment.
METHODS : We interviewed patients aged ≥ @number@ y preoperatively and repeated functional and cognitive assessments at 4-6 wk and 4-6 mo postoperatively.
METHODS : We investigated a population-based sample of @number@ men aged 42-62 years at baseline during 1984-1989.
METHODS : We investigated @number@ healthy participants who completed the TCI.
METHODS : We investigated patient expectation and satisfaction using a 14-item questionnaire in @number@ female patients.
METHODS : We investigated the age ( lifespan ) of circulating erythrocytes in subjects with CF-LVAD.
METHODS : We investigated the gene-smoking interactions in DNA methylation using @number@ individuals from the Epidemiological Investigation of Rheumatoid Arthritis ( EIRA ) .
METHODS : We investigated the internal consistency , test-retest reliability and the validity of BARS.
METHODS : We investigated the people with dementia living in @number@ care homes in London and Buckinghamshire , United Kingdom.
METHODS : We investigated the prevalence and clinical features of CU in elderly patients.
METHODS : We investigated whether internet use and social engagement protect against health literacy decline during ageing , independent of cognitive decline.
METHODS : we investigated whether leukocyte TL was related to brain atrophy and WMHs in a sample of @number@ non-demented individuals aged 64-75 years.
METHODS : We investigated whether spinal pain increased the rate of all-cause and disease-specific cardiovascular mortality in older Danish twins aged ≥70 years.
METHODS : We made a non-interventional , prospective , observational study in elderly institutionalized people.
METHODS : We measured gene-specific blood DNA methylation repeatedly in @number@ elderly men participating in the Normative Aging Study ( 1999-2010 ) .
METHODS : We measured plasma biomarker levels at baseline and @number@ hours in consecutive AIS subjects.
METHODS : We measured plasma fibrinogen , C-reactive protein , and interleukin-6 and rated PVS in @number@ brain regions.
METHODS : We measured SCD in a group of @number@ children aged 0-18 years in the curved left lateral position using ultrasound.
METHODS : We measured serum metabolites using liquid chromatography-tandem mass spectrometry in @number@ children , aged 12-59months , from rural Malawi.
METHODS : We measured the telomere length in placental tissues of @number@ twins in the East Flanders Prospective Twin Survey.
METHODS : We obtained 24-h beat-to-beat RR data using a high resolution 12-lead Holter ECG in a community-dwelling sample of @number@ non-smokers.
METHODS : We obtained incident ED status and participant data for @number@ men ( age 57-85 ) .
METHODS : We partnered with a large international financial services company and used a qualitative synthesis based on an intervention mapping methodology.
METHODS : we performed a 2-year ( 2012-2013 ) prospective cohort analysis of all consecutive geriatric ( age , ≥ @number@ years ) trauma patients.
METHODS : We performed a cohort analysis of young and middle-age male Sprague-Dawley rats treated with 5-ethynyl-2'-deoxyuridine ( EdU ) pulse followed by Li-ESWT.
METHODS : We performed a cross-sectional analysis of @number@ patients who were diagnosed with IgAN by renal biopsy.
METHODS : We performed a cross-sectional study of CTS , analysing the correlation between severity and age.
METHODS : We performed a cross sectional survey among all parents of newborns born between May and @date@ and @number@ in Basel city and country.
METHODS : We performed a literature review of MB , with a particular emphasis on electrocardiographic manifestations.
METHODS : We performed a longitudinal analysis using data regarding @number@ individuals drawn from the Korean Longitudinal Study of Aging ( KLoSA ) .
METHODS : We performed a Medline , Ovid , and EMBASE search using search words rhegmatogenous , retinal detachment , vitreous , and retinal adhesion.
METHODS : We performed an analysis of consecutive patients with syncope presenting to the emergency department.
METHODS : We performed a nationwide epidemiological survey of MG in Japan.
METHODS : We performed a nationwide survey of @number@ randomly selected home-visit nursing agencies in Japan.
METHODS : We performed annual assessment of @number@ women who were premenopausal at baseline and reached natural menopause within @number@ years of follow-up.
METHODS : We performed a population-based cohort study to compare mortality in OS and SS twins.
METHODS : We performed a population-based cross-sectional study including @number@ men who lived in urban area.
METHODS : We performed a prospective cohort study at a primary care geriatrics practice that provides care to @number@ SLCs.
METHODS : We performed a prospective cohort study of consecutive healthy and well-functioning patients hospitalized for this type of pneumonia.
METHODS : We performed a research of multiple databases and present important studies in this narrative review.
METHODS : We performed a retrospective analysis of the prospective database of our level @number@ trauma center.
METHODS : We performed a retrospective cohort study using prospectively collected data from our arthroplasty database.
METHODS : We performed a retrospective cross-sectional study between @date@ and @date@ at a tertiary referral center in Utah.
METHODS : We performed a retrospective study of first transplants using a single-centre electronic database.
METHODS : We performed a retrospective study using data from the Norwegian Patient Registry and Statistics Norway.
METHODS : We performed a search for Spanish and English articles , in indexed journals from medical databases.
METHODS : We performed a search in MEDLINE by combining search terms on delirium and opioids.
METHODS : We performed a secondary analysis of the Inflammation and Host Response to Injury database of adults with severe blunt trauma.
METHODS : We performed a series of @number@ USCOM scans in @number@ patients of all ages after induction for routine surgery.
METHODS : We performed a systematic review and meta-analysis.
METHODS : We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white population.
METHODS : We performed a systematic search of PubMed , Embase , and Cochrane Central Register of Controlled Trials until @date@ .
METHODS : We performed biochemical analyses after intraepidermal Er : YAG laser resurfacing of @number@ patients.
METHODS : We performed CTP on @number@ consecutive ICH patients within @number@ to @number@ h after symptom onset.
METHODS : We performed epidemiological , cytokine , and transcriptomic analyses on a prospective , multi-center cohort of @number@ severely injured patients.
METHODS : We performed genome-wide DNA methylation profiling on participants involved in a population-based incident case-control study of bladder cancer.
METHODS : We performed germline mutation analyses of mismatch repair genes in @number@ patients.
METHODS : We performed isokinetic evaluations of muscle groups in the ankle and foot including dorsiflexors , plantar flexors , inversion , and eversion.
METHODS : We performed Kinetic magnetic resonance imaging for @number@ consecutive patients experiencing neck pain without neurologic symptoms.
METHODS : We performed LCA based on neuropsychological test results of @number@ consecutive probable patients with AD dementia using Mini-Mental State Examination as the covariate.
METHODS : We performed longitudinal neuropsychological testing on an APOE ε4 enriched cohort , ages 21-97.
METHODS : We performed medline searches for original articles and reviews of carotid IMT from @number@ to the present.
METHODS : We performed secondary analyses of @number@ Healthcare Utilization Project National ED Sample from @number@ admissions to U.S. EDs linked to injured elderly patients.
METHODS : We performed spectral-domain optical coherence tomography in @number@ eyes of @number@ normal subjects of various ages in a sitting position.
METHODS : We performed structural brain MRI and DCE-MRI in @number@ patients with clinically overt cSVD and @number@ age- and sex-matched controls.
METHODS : We performed time trend analysis using a Quebec congenital heart disease database constructed from administrative data.
METHODS : We pooled individual participant data of @number@ community-dwelling older adults from five cohort studies.
METHODS : We present a retrospective single-center study , performed between @date@ and @date@ , that comprises a sample of @number@ liver transplants.
METHODS : We present a review of the literature and three cases of nasal alar necrosis after dermal filler injection.
METHODS : We profiled miRNAs in CSF from @number@ AD patients and @number@ controls using TaqMan® arrays.
METHODS : We prospectively collected @number@ consecutive patients subjected to mechanical thrombectomy for proximal occlusion of the anterior circulation during a period of @number@ months.
Methods : We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists.
METHODS : We prospectively measured faecal occult blood levels by a quantitative immunochemical FOBT ( RIDASCREEN ) in @number@ average-risk subjects undergoing screening colonoscopy.
METHODS : We prospectively recruited eight FAP patients with transthyretin mutations and ten age-matched control patients with other neuropathies in our university.
METHODS : We provide long-term forecasts of healthcare use and costs at the Quebec population level using a novel dynamic microsimulation model.
METHODS : We randomized @number@ patients with proximal humeral fractures to receive one of these two approaches ( @number@ patients for each approach ) .
METHODS : We randomly selected a representative sample ( n = @number@ ) of people over @number@ from Narón Council ( A Coruña ) .
METHODS : We received @number@ valid WHOQOL-OLD questionnaires from @number@ respondents who were @number@ and older by quota sampling method.
METHODS : We recorded eye movements in @number@ subjects ( NE : @number@ MCI : @number@ AD : @number@ ) during an AS task.
METHODS : We recruited a community-representative sample of @number@ @number@ men aged 65-83 years and followed them for 10-13 years.
METHODS : We recruited @number@ Chinese community-living adults @number@ years or older.
METHODS : We recruited @number@ CKD patients admitted to our hospital division and referred with data in this cross-sectional study.
METHODS : We recruited @number@ clinically normal subjects for the study.
METHODS : We recruited @number@ consecutive outpatients with AD , @number@ with MCI , and @number@ normal cognitive aging controls ( NC ) .
METHODS : We recruited @number@ consecutive patients who underwent LEMG.
METHODS : We recruited @number@ elderly participants , and obtained blood and urine samples during repeated medical examinations.
METHODS : We recruited @number@ healthy Chinese adults , aged @number@ to @number@ years , from the Singapore Chinese Eye Study , a population-based survey.
METHODS : We recruited @number@ healthy subjects.
METHODS : We recruited @number@ healthy volunteers ( @number@ men ) free of any systemic or cardiovascular disease.
METHODS : We recruited @number@ homeless individuals aged ≥50 years using population-based sampling and conducted structured interviews and neuropsychological testing.
METHODS : We recruited @number@ men aged 71-87 years who were free of cognitive impairment.
METHODS : We recruited @number@ mother-infant dyads at infant age < @number@ days.
METHODS : We recruited @number@ participants aged @number@ to @number@ years.
METHODS : We recruited @number@ patients with AD , @number@ participants with aMCI , and @number@ healthy controls.
METHODS : We recruited @number@ peri- or postmenopausal women aged @number@ to @number@ years ( mean age , @number@ years ) .
METHODS : We recruited @number@ women and @number@ men as the study population.
METHODS : We recruited participants with minor ischemic stroke and performed clinical assessments and brain MRI.
METHODS : We recruited randomly selected adults aged @number@ or older residing in the rural Agincourt sub-district in Mpumalanga Province.
METHODS : We recruited women in labor upon hospital delivery admission.
METHODS : We refined an existing method to impute unmedicated BP in individuals on antihypertensives by incorporating new treatment trends.
METHODS : We re-interpret the scientific literature in order to provide a rationale for physical therapy treatments for discogenic back pain.
METHODS : We report a case of iatrogenic adrenal insufficiency interaction secondary to ritonavir and inhaled fluticasone in an HIV-infected patient with COPD.
METHODS : We report a HCV-1b patient who received only @number@ days of PROD treatment.
METHODS : We report the economic impact of primary open-angle glaucoma and model the effect of changes in detection rates and management strategies.
METHODS : We report the long-term follow-up of @number@ children who underwent temporal lobe surgery after an average postoperative period of @number@ years.
METHODS : We retrospectively analysed patients who underwent primary THA.
METHODS : We retrospectively analyzed a database of @number@ cancer patients who were consecutively recruited in a previous multicenter cross-sectional study.
METHODS : We retrospectively analyzed @number@ consecutive patients with spontaneous supratentorial ICH identified by a database search.
METHODS : We retrospectively analyzed @number@ patients who underwent lobectomy or pneumectomy in Chinese PLA General Hospital from @date@ to @date@ .
METHODS : We retrospectively assessed the agreement between the two diagnoses in @number@ MCI patients.
METHODS : We retrospectively enrolled @number@ patients , in our Trauma Center , underwent surgery procedures for FFP between @number@ and @number@
METHODS : We retrospectively evaluated the long-term clinical evolution , and genotype-phenotype correlations in @number@ genetically identified BM patients ( @number@ index cases ) .
METHODS : We retrospectively identified all consecutive admissions from NHs to an Acute Medical Assessment Unit between @date@ and @date@ .
METHODS : We retrospectively reviewed a database of our tertiary care stone clinic patients seen from @date@ to @date@ .
METHODS : We retrospectively reviewed data from patients treated with sorafenib for HCC at our institution.
METHODS : We retrospectively reviewed @number@ elective PCIs that were performed between @date@ and @date@ at the Red Cross General Hospital.
METHODS : We retrospectively reviewed the pre and postoperative EEG with effective hyperventilation in @number@ pediatric moyamoya patients and compared their patterns with hemodynamic images.
METHODS : We retrospectively reviewed the records of @number@ patients who underwent dynamic renal scintigraphy in the last @number@ years.
METHODS : We retrospectively studied @number@ inpatients with CVD ( age 72±12 years ) .
METHODS : We retrospectively studied @number@ patients diagnosed with typical RP and @number@ control subjects.
METHODS : We retrospectively studied the records of CD patients presenting to the National Taiwan University Hospital , Taipei , Taiwan between @number@ and @number@
METHODS : We review and discuss the current practices and challenges regarding endpoints in RCTs in this field and propose novel approaches.
METHODS : We reviewed all cases admitted to our institution between @date@ and @date@ with symptomatic bradyarrhythmia for whom a permanent pacemaker was implanted.
METHODS : We reviewed all patients treated with GKRS for BM at our institution between @date@ and @date@ .
METHODS : We reviewed data from Demographic and Health Surveys ( DHS ) .
METHODS : We reviewed @number@ consecutive cases with acute aSAH with surgical indication for aneurysm repair.
METHODS : We reviewed @number@ patients with MMD undergoing Xenon-enhanced computed tomography , as well as @number@ patients with CAD and @number@ controls.
METHODS : We reviewed the literature and identified systematic reviews of cohort studies and other authoritative reports.
METHODS : We reviewed the number of spinal procedures performed by neurosurgeons in Belgium between @number@ and @number@
METHODS : We reviewed the relevant literature , i.e. , systematic reviews and meta-analyses searched with PubMed.
METHODS : We searched MEDLINE and ClinicalTrials.gov for studies from @number@ to @number@
METHODS : We searched Medline ( PubMed ) and CINAHL ( EBSCOhost ) databases until the end of @date@ .
METHODS : We searched multiple databases for studies published from @number@ to @number@
METHODS : We searched Ovid Medline , Embase , Cochrane Library , Web of Science , CINAHL , PsycInfo , and Sociological Abstracts.
METHODS : We searched Pubmed and vendor websites to identify relevant information.
METHODS : We searched PubMed , Embase and the Cochrane Library database up to @date@ .
METHODS : We searched PubMed , EMBASE , and the Cochrane Library up to @date@ , and included studies reporting rotator cuff abnormalities by age.
METHODS : We searched PubMed , Embase , PsycINFO , CINAHL , Web of Science , Cochrane Library , and Age Line.
METHODS : We searched PubMed , Embase , PsycINFO , CINAHL , Web of Science , Medline , and the Cochrane Library.
METHODS : We searched PubMed for articles that addressed the various factors affecting employment after OLT.
METHODS : We searched ten electronic databases and used the Physiotherapy Evidence Database ( PEDro ) scale to assess the methodological quality of included studies.
METHODS : we searched the PubMed and EMBASE databases.
METHODS : We selected @number@ candidate genes and @number@ single nucleotide polymorphisms ( SNPs ) tagging common variation in each gene.
Methods : Western blotting of anti-CarP antibodies was conducted.
METHODS : We studied a cohort of @number@ dementia-free participants aged 83-96 years.
METHODS : We studied a national cohort of HIV-infected and matched HIV-uninfected individuals who received care through the Veterans Healthcare Administration.
METHODS : We studied a @percent@ sample of Medicare beneficiaries enrolled in Medicare parts A , B and D and hospitalized for COPD in @number@
METHODS : We studied ARV-treated patients attending a tertiary care center.
METHODS : We studied a single-centre cohort of @number@ patients with craniopharyngioma treated from @number@ onwards ( @number@ patients with childhood-onset disease ) .
METHODS : We studied characteristics of participants using Web-based and printed intervention materials in a randomized controlled trial ( RCT ) .
METHODS : We studied @number@ asymptomatic subjects wearing an ambulatory monitor with acoustic cardiography.
METHODS : We studied @number@ caregivers aged 38-87 years in a cross-sectional study.
Methods : We studied @number@ chronic shift workers and @number@ non-shift workers as controls using both field and in-laboratory experiments.
METHODS : We studied @number@ computed tomographic scans of children from birth to @number@ months of age undergoing radiological evaluation unrelated to airway symptomatology.
METHODS : We studied @number@ consecutive post-myocardial infartion patients ( mean age @number@ years ) .
METHODS : We studied @number@ FRDA patients and @number@ healthy volunteers using a @number@ T scanner.
METHODS : We studied @number@ healthy volunteers ( age = @number@ ± 15years , @number@ females ) who had MRI with simultaneous blood pressure measurements.
METHODS : We studied @number@ members of a family in which some had bulbar motor neuropathy , and we performed exome sequencing.
METHODS : We studied @number@ older adults ( ≥ @number@ years ) who were dementia-free at baseline over a period of up to @number@ years.
METHODS : We studied @number@ oldest old subjects ( ≥ @number@ yrs , mean age @number@ ) living in a residential home.
Methods : we studied @number@ participants ( mean age @number@ years , SD @number@ ) from the Helsinki Birth Cohort Study.
METHODS : We studied @number@ participants of the InCHIANTI study ( @number@ men and @number@ women , age range : 21-94 yrs ) .
METHODS : We studied @number@ participants of the Korean Longitudinal Study on Health and Aging ( KLoSHA ) .
METHODS : We studied @number@ patients ( 19-68 years ) who had been referred by a physician for a baseline polysomnography ( PSG ) evaluation.
METHODS : We studied @number@ patients ( 62±9years , @percent@ female ) with T2DM.
METHODS : We studied @number@ patients ( age @number@ ± @number@ years ) .
METHODS : We studied @number@ patients , referred to our Hypertension Centre , in whom ABPM , blood tests , and echocardiography were clinically indicated.
METHODS : We studied @number@ patients with acute decompensated HF from @number@ prospective observational cohorts followed-up across @number@ continents.
METHODS : We studied @number@ patients with IDC who had been treated with the therapy.
METHODS : We surveyed attendees at a national neuroscience conference on the factors that influence their pursuit of careers in clinical neurosciences.
METHODS : We surveyed inpatients on their room preference in @number@ and repeated the survey with inpatients in the new unit in @number@
METHODS : We surveyed patient data for @number@ cases diagnosed at a number of centers across Japan.
METHODS : We systematically searched Embase and PubMed databases.
METHODS : We systematically searched MEDLINE , EMBASE , Web of Science , and Cochrane Library databases up to @date@ .
METHODS : We systematically searched PubMed and the Cochrane Database of Systematic Reviews from inception to @date@ , and the references of retrieved relevant articles.
METHODS : We treated three patients including a patient with an AMD treatment resistant variant ( polypoidal retinal vasculature disease ) .
METHODS : We undertook an analysis of mitochondrial haplogroups in a large , well-characterized cohort of @number@ TBI patients.
METHODS : We undertook a prospective cohort study comparing cost and health care utilization outcomes between ECHO-CT facilities and matched comparisons from @date@ -December @number@
METHODS : We undertook a systematic review and obtained individual participant data from @number@ studies.
METHODS : We undertook a two stage process to develop the framework.
METHODS : We used a large-scale miRNA analysis of @number@ samples including AVMs , hemangioblastoma , and controls to identify a distinct AVM miRNA signature.
METHODS : We used a literature review for analysis.
METHODS : We used a @percent@ random national sample of Medicare claims data to identify average-risk patients who underwent screening colonoscopies from @number@ to @number@
METHODS : We used a phenomenological approach , using Martin Heidegger’s philosophical frame.
METHODS : We used a pretest / posttest design with objectives aimed at measuring increases in research productivity following a targeted intervention.
METHODS : we used a subsample of @number@ adults aged ≥ @number@ years from the @number@ China Health and Nutrition Survey.
METHODS : We used a three-stage age-at-onset informed GWAS to identify novel genetic variants associated with stroke.
METHODS : We used baseline data from the SNAC-K ( Swedish National Study of Aging and Care - Kungsholmen ) .
METHODS : We used combined data from two prospective observational cohorts of adult patients with pneumonia.
METHODS : We used cross-sectional data ( Aging , Demographics , and Memory Study ) to estimate probabilities of experiencing outcomes by clinical features.
METHODS : We used data from a population-based , cross-sectional study from Matlab , in rural Bangladesh , on @number@ persons aged 60 + years.
METHODS : We used data from @number@ men and women belonging to the Northern Finland Birth Cohort @number@
Methods : We used data from @number@ older persons without dementia.
METHODS : We used data from six cohorts of participants aged @number@ years or older at recruitment to calculate DALYs.
METHODS : We used data from the Danish National Birth Cohort.
METHODS : We used data from the first to fourth wave of the Korean Longitudinal Study of Aging.
METHODS : We used data from the Korean Longitudinal Study of Aging ( KLoSA ) .
METHODS : We used data from the Longitudinal Aging Study Amsterdam ( N = @number@ ) .
METHODS : We used data from the National Inpatient Sample to identify patients with a principal diagnosis of C. difficile infection from @number@ to @number@
METHODS : We used data from the @number@ Health Indicators Project , a cross-sectional survey of @number@ older adults attending @number@ NYC senior centers.
METHODS : We used data from two large prospective population-based epidemiological dementia studies conducted in two adjacent regions during the period 1987-2012.
METHODS : We used data from waves @number@ to @number@ of the English Longitudinal Study of Ageing ( ELSA ) .
METHODS : We used data of a national representative Internet panel in the Netherlands.
METHODS : We used dynamic causal modelling ( DCM ) to study connectivity models for healthy young and old subjects.
METHODS : We used event-related fMRI in a choice reaction-time task and provided performance feedback after each trial.
METHODS : We used independently available data to supplement a survey of nursing home administrators.
METHODS : We used linked health administrative data from Ontario , Canada.
METHODS : We used mortality data from the Global Burden of Disease Study @number@ which includes data on @number@ countries grouped into @number@ world regions.
METHODS : We used national Medicare data to study patients undergoing one of eight different cancer and cardiovascular operations from @number@ through @number@
METHODS : We used patient data from a large commercial health insurer from 2002-2005.
METHODS : We used pooled individual-level data from the Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium.
METHODS : we used real-time quantitative PCR to examine the gene expression profiles in cumulus cells acquired from older and younger age groups.
METHODS : We used six waves of the biennial English Longitudinal Study of Ageing spanning 2002-2012.
METHODS : We used standard searches to find publications using ADNI data.
METHODS : We used the database \ "Health and Social Support of Elderly Population in Community \ ".
METHODS : We used the data from @number@ to @number@ from the Korea National Health and Nutrition Examination Survey.
METHODS : We used the nationally representative data of more than @number@ million adults aged @number@ to @number@ years in the 2010-2014 American Community Survey.
METHODS : We used the second China National Sample Survey on Disability , comprising @number@ persons from @number@ households.
METHODS : We used three data-sources.
METHODS : We use period analysis and modeled period analysis to disclose recent trends in survival in patients with head and neck cancer.
METHODS : We utilized billing records of children aged @number@ to @number@ years in @number@ US states ' Medicaid programs between @number@ and @number@
Methods which satisfy the needs of a @number@ year-old may not be suitable for the @number@ year-old.
METHODS : While resting at a temperature of 42°C , relative humidity increased from @percent@ to @percent@ in @percent@ increments every @number@ min.
Methods : Whole-muscle cross sections from the middle portion of the medial rectus were labeled with antibodies against MyHCI or MyHCsto and laminin.
METHODS : With a decision-tree , we modelled the first @number@ weeks of nortriptyline therapy.
METHODS : With respect to randomized controlled trials ( RCTs ) regarding Alzheimer's disease and hip fractures , the literature was searched with PubMed.
METHODS : With the patients under local tumescent anesthesia , extraoral incisions were made in nine cases and intraoral incisions in two cases.
METHODS : WMH volumes were acquired using 3T MRI for @number@ Dallas Heart Study participants.
METHODS : Women ( N = 88 , 829 ) without diagnosed diabetes reported the number of hours spent sitting over a typical day.
METHODS : Women seen in outpatient female urology clinics were identified by ICD-9 codes for OAB and recruited.
METHODS : Women undergoing to ART for various infertility conditions were included in the study.
METHODS : Women with AJCC stage @date@ breast cancer who underwent a mastectomy were surveyed.
METHODS : Women with Stage IIIC / IV EOC who underwent PDS between @date@ - @date@ were included.
METHODS : Workers aged 55-62 years were selected from the 2002-2003 cohort of the Longitudinal Aging Study Amsterdam ( n = @number@ ) .
METHODS : Yarning Circles were held with Aboriginal and Torres Strait Islander people aged @number@ years and over.
METHODS : Young and elderly adults performed a probabilistic implicit sequence-learning task before and after a 12- , a 24-hr , and a 1-week interval.
METHODS : Young and elderly subjects were required to make a step in response to support surface perturbations.
METHODS : Young and older adults performed the noun-pair lookup ( NP ) task.
METHODS : Younger adults , older adults and AD participants were presented with two sets of six items each : Set1 and Set2.
METHOD : Systematic coding procedures of the DOSC measurement were applied to @number@ participants from the Copenhagen Aging and Midlife Biobank ( CAMB ) survey.
METHOD : Systematic review and meta-analysis of prospective controlled trials.
METHODS : Α random sample of @number@ children was extracted from a national database and matched with their mothers.
METHOD : Ten patients were split into @number@ groups ( A and B ) .
METHOD : The 3-Tier Assessment System consisted of tiered series of screening tools incorporated into the in-office driver's license renewal process.
METHOD : The analyses utilize data from the National Survey of Midlife in the United States ( @number@ ) .
METHOD : The authors measured lexical decision reaction times ( RTs ) when intact target words followed acoustically distorted sentence contexts.
METHOD : The authors used data from @number@ waves of the Longitudinal Aging Study Amsterdam ( 4-year follow-up , baseline ages 63-93 years ) .
METHOD : The Capital Region of Denmark runs a quality database for dementia evaluation in the secondary health system.
METHOD : The CSDD was completed for @number@ patients on their first visit to a memory clinic or an outpatient clinic.
METHOD : The data come from a larger study focused on the empowerment of DCWs in NHs.
METHOD : The data were derived from a population-based cross-sectional study among community-dwelling individuals aged @number@ and older.
METHOD : the deans of all @number@ UK medical schools were invited to nominate a respondent with an overview of their undergraduate curriculum.
METHOD : The Embase , MEDLINE , and PsycINFO databases were searched.
METHOD : The face and content validity test was based on focus group discussions and individual interviews with @number@ informants.
METHOD : The final sample consisted of @number@ consecutive participants.
METHOD : The final sample included @number@ participants.
METHOD : The Geriatric Suicide Ideation Scale ( GSIS ; [ Heisel et al.
METHOD : The HDPE / HA nano-composite is prepared using melt blending at different HA loading ratios.
METHOD : The hypothesized genetic buffer was measured using a polygenic score derived from a published genome-wide association study of subjective well-being.
METHOD : The hypothesized model was empirically tested using data collected from a survey of @number@ residents older than @number@ years in China.
METHOD : The literature search was limited to studies conducted from @number@ to @number@ that were published in English in peer-reviewed journals.
METHOD : The Lothian Birth Cohort @number@ is a longitudinal study of cognitive aging.
METHOD : The MNA was applied to @number@ residents of two municipal nursing homes in Nuremberg , Germany.
Method : The MoCA was administered to @number@ African American participants ( mean age @number@ years , range 18-75 , @percent@ female ) .
Method : The Montreal Cognitive Assessment ( Nasreddine et al. , @number@ ) was used to classify participants as with or without probable MCI.
METHOD : The P15 was completed in a cross-sectional design for a stratified sample of @number@ adults with ID across @number@ European member states.
METHOD : The panel data are from two waves of the Norwegian study of the life course , ageing and generations.
METHOD : The participants in this cross-sectional population study included @number@ people between the ages of @number@ and @number@
METHOD : The participants were @number@ adults enrolled in the National Study of CDSMP in 2010-2012 ( M age = 65.4 years ) .
METHOD : The participants were @number@ family caregivers of people with dementia.
METHOD : The performance of middle-aged adults on laboratory-based speech understanding tasks was compared to that of younger and older adults.
METHOD : The present study uses a national sample of @number@ community-dwelling individuals aged @number@ years and older from the English Longitudinal Study of Ageing.
METHOD : The present study was part of a population-based prospective trial aimed at reducing the incidence of stroke and dementia.
METHOD : The prevalence and incidence of various kidney replacement therapies in the Netherlands from @number@ to @number@ were analysed.
METHOD : The procedure used in the present study combined the AMI and AI into one study session.
METHOD : The results revealed that the ability to coordinate attention increases with age , reaching adult values by age @number@ years.
METHOD : There were @number@ important innovations.
METHOD : The sample comprised a total of @number@ adults from Greece , aged from @number@ to @number@ years.
METHOD : The sample comprised @number@ adults ages 55-65 years at baseline.
METHOD : The sample comprised @number@ CAMB participants from three cohorts with scores on the Intelligenz-Struktur-Test @number@ R ( I-S-T @number@ R ) .
METHOD : The sample comprised @number@ older adults aged 75-91 years.
METHOD : The sample consisted of @number@ community-dwelling older Korean immigrants in Florida and New York.
METHOD : The sample consisted of @number@ Medicare beneficiaries who reported having an ongoing relationship with a primary care physician.
METHOD : The sample consisted of @number@ participants from the English Longitudinal Study of Ageing , a prospective study of community-dwelling older adults.
METHOD : The sample consisted of @number@ ( @percent@ non-Hispanic white , @percent@ non-Hispanic black , and @percent@ Caribbean Hispanic ) older adults.
METHOD : The sample consisted of @number@ younger and older adults aged between @number@ and @number@
METHOD : The sample included @number@ gay men and lesbian women aged 50 + years.
METHOD : The sample included @number@ Israeli firefighters who took active part in extinguishing the @number@ Mount Carmel forest fire.
METHOD : The sample in this study consisted of @number@ participants aged @number@ years and over , with a mean age of @number@ years.
METHOD : The sample involved data for @number@ respondents who were participating in the first wave of The Irish Longitudinal Study on Ageing.
METHOD : The study comprises national surveys conducted in Bulgaria , Italy , and Latin America and the Caribbean.
METHOD : The study employed a community-based , cross-sectional design.
METHOD : The study employed a three-group pre-post-test design with random allocation to instrumental or integrative reminiscence or an active social discussion control condition.
METHOD : The study group was composed of @number@ healthy elderly subjects who underwent neuropsychological assessment and quantitative magnetic resonance imaging.
METHOD : The study included a convenience sample of @number@ dyads of respondents.
METHOD : The study sample comprised @number@ community-dwelling older adults aged ⩾65 years from the Longitudinal Aging Study Amsterdam ( LASA ) .
METHOD : The study uses claims data for a @percent@ sample of Medicare beneficiaries with an incident hip fracture hospitalization between @number@ and @number@
METHOD : The study was a cross-sectional observational study , set in Canberra , Australia.
METHOD : The study was conducted as a randomized double-blind test of @number@ subjects in their 50s , including @number@ males and @number@ females.
METHOD : The subjects with kyphosis were @number@ elderly people in a facility providing health care services for the elderly.
METHOD : The Sydney Memory and Aging Study invited participants randomly from the electoral roll in defined geographic areas in Sydney.
METHOD : The validity of the method is tested by re-evaluating the development of RB in retrospect.
METHOD : Thiamin concentration was measured in @number@ consecutive admissions of patients aged over @number@ years in a secondary care hospital.
METHOD : Thirty older adults with SNHL participated.
METHOD : Thirty-three right-handed participants were MRI scanned to measure the volume of the CC in @number@ sections.
METHOD : Thirty volunteers were randomized into two groups-Pilates group ( PG ) and Control Group ( CG ) .
METHOD : This critical ethnography engaged ten older adults aging with vision loss in narrative interviews , participant observation sessions , and semi-structured in-depth interviews.
METHOD : This cross-sectional study included @number@ adults ages 65-84 from the Chicago Healthy Aging Study ( CHAS - 2007-2010 ) .
METHOD : This cross-sectional study included @number@ community-living participants aged ≥60 years in the Confucius Hometown Aging Project of China.
METHOD : This cross-sectional study included @number@ participants ( age ≥60 years , @percent@ women ) in the Confucius Hometown Aging Project.
METHOD : This cross-sectional study includes @number@ participants from the Baltimore Longitudinal Study of Aging.
METHOD : This exploratory , cross-sectional study examined employees of a higher education institution ( HEI ) and those of a metallurgical industry.
METHOD : This interpretive , qualitative study involved key informant interviews with @number@ women with self-identified HIV-associated neurocognitive challenges.
METHOD : This is a cross-sectional study in a nationally representative sample of adults aged 50-79 years ( n = @number@ ) .
METHOD : This is a cross-sectional study in @number@ physically-independent and apparently healthy older men and women subjects from a central region of Mexico.
METHOD : This is a descriptive correlational study using a secondary data base , Social Environment and Biomarkers of Aging Study.
METHOD : This is a descriptive study done on @number@ general physicians working in public and private sectors.
METHOD : This is a four-year retrospective cohort and nested case-control study at a Canadian tertiary-care hospital using data from @date@ to @date@ .
METHOD : This is a theoretical article based on a review of preexisting findings pertaining to fear of falling and falls efficacy.
METHOD : This longitudinal study of a Taiwan population analyzed a nationally representative sample of @number@ subjects aged @number@ years and over.
METHOD : This multicenter , randomized , double-blinded , double-dummy , noninferiority , positive drug-controlled clinical trial was conducted in five Chinese sites.
METHOD : This paper is based on video-recordings of communication within a UK memory clinic.
METHOD : This randomized trial tested whether cognitive training over @number@ weeks improves balance and gait in older adults.
METHOD : This retrospective study used administrative data for @number@ clients who died while receiving home care services.
METHOD : This study included @number@ Chinese men ( mean age , @number@ ± @time@ ) with EH.
METHOD : This study investigated annual thyroid function tests in @number@ adults with Down syndrome over a 15-year period.
METHOD : This study is based on video- and audio recordings of @number@ initial consultations between neurologists and patients referred to a UK memory clinic.
METHOD : This study links survey data on retirement planning with information on respondents ' own health histories and those of their parents.
METHOD : This study used a mixed-method approach where @number@ individuals with lower limb amputation completed the individual leisure profile 2-3 months post-discharge from rehabilitation.
METHOD : This study used a prospective longitudinal design.
METHOD : This study used two waves from the Health and Retirement Study.
METHOD : This study uses data on self-identified Asian Americans aged over age @number@ years derived from the @number@ California Health Interview Survey.
METHOD : This study uses the data from the \ "Survey of Health and Living Status of the Elderly in Taiwan \ ".
METHOD : This was a 3-year study.
METHOD : This was a clinical intervention study of @number@ women over the age of @number@ living in Novi Sad , Serbia.
METHOD : This was a cross-sectional study.
METHOD : This was a cross-sectional study of a representative sample of @number@ individuals aged @number@ or more.
METHOD : This was a cross sectional survey of gynaecology clinic attendees at the university of Nigeria Teaching Hospital ( UNTH ) , Enugu.
METHOD : This was a descriptive study with a single interview and blood draw done with residents in a continuing care retirement community.
METHOD : This was a longitudinal qualitative study.
METHOD : This was an exploratory study using a qualitative methodology.
METHOD : This was a prospective , controlled , split-face study with @number@ subjects.
METHOD : This was a qualitative study among @number@ spouses of persons with dementia , recruited via purposeful sampling.
METHOD : This was a qualitative study using grounded theory.
METHOD : This was a single group , cross-sectional study.
METHOD : This work was based on two surveys of older adults aged @number@ years or more in Spain.
METHOD : This work was conducted as a cross-sectional study.
Method : Three experiments of Mandarin tone perception were conducted for younger and older listeners with Mandarin Chinese as the native language.
METHOD : Three out of @number@ elderly health centres were selected using the cluster sampling method.
METHOD : To reach this goal , the Building Realization and Robotics Lab is researching in the field of ambient assisted living.
METHOD : Tract integrity was determined using quantitative diffusion magnetic resonance imaging tractography ( tract-averaged fractional anisotropy [ FA ] ) .
METHOD : Twelve English-speaking children participated in @number@ tasks designed to elicit auxiliary BE in declaratives and yes / no and wh-questions.
METHOD : Twenty in-depth qualitative interviews with spousal carers from two carer support groups and a care home in North West England.
METHOD : Twenty-seven consecutive PD patients ( mean age @number@ years ) were enrolled.
METHOD : Twenty-seven ( @number@ men , @number@ women ) community-dwelling older adults attended @number@ data collection events.
METHOD : Twenty-six semi-structured interviews were undertaken with community stakeholders across two rural communities in north-east Victoria.
Method : Twenty speakers with PD and @number@ healthy speakers read sentences with target words that varied in word frequency and neighborhood density.
METHOD : Twenty young and @number@ old adults performed a laboratory and a naturalistic prospective memory task , which were similar in structure and demand.
Method : Twenty younger and @number@ older adults with age-normal hearing participated.
METHOD : Two case presentations of the benefits and challenges of including multiple caregivers in treatment are discussed.
METHOD : Two Swedish nationally representative Level of Living Surveys ( total N = @number@ ) were used.
METHOD : UI was assessed using the International Consultation on Incontinence Questionnaire Short-Form and a specific severity UI item.
METHOD : Unilateral leg press resistance exercise was conducted daily during the hospital period.
METHOD : Up to @number@ waves of longitudinal cognitive data were collected from @number@ autopsied participants from @number@ ongoing clinical-pathologic cohort studies of aging.
METHOD : Using real-time PCR , mtDNA quantification was analyzed in unfertilized oocytes and uncleaved embryos.
METHOD : Vocal-fold vibrations were analyzed for @number@ children ( aged 5-11 years ) and @number@ adults ( aged 21-45 years ) without voice disorders.
METHOD : We acquired staff demographics , knowledge of dementia and sexuality , and attitudes of sexuality.
METHOD : We analysed the mortality database in Chile from @number@ to @number@
METHOD : We analyze data from semistructured in-depth interviews with @number@ older rural adults.
METHOD : We analyzed data from @number@ Medicare beneficiaries who participated in a Medicare demonstration.
METHOD : We analyzed the available data from @number@ participants in the Korean Longitudinal Study on Health and Aging.
METHOD : We asked young and older adults to verify arithmetic problems that violated or respected arithmetic rules ( i.e. , 5×16 = @number@
METHOD : We collected and analyzed HbA1C , glycated hemoglobin , a biomeasure of average blood sugar concentrations within the past few months.
METHOD : We conducted a mail survey of @number@ family caregivers.
METHOD : We conducted an exploratory analysis , using longitudinal survey phenotype / genotype data from @number@ oldest-old aged 90 + .
METHOD : We conducted four focus groups between @number@ and @number@ in the UK with @number@ family members and @number@ care staff.
METHOD : We conducted interviews with @number@ older people residing in public housing estates in Hong Kong.
METHOD : We conducted semi-structured interviews with @number@ healthcare professionals working for or being associated with the largest SCI clinic in Switzerland.
Method : We conducted six focus groups among Chinese-speaking adult women age @number@ and above.
METHOD : We conducted six focus groups with @number@ caregivers of patients with dementia and type @number@ diabetes.
METHOD : We describe the new measures and compare the distributions of each across gender and age groups , in some cases by partnership status.
METHOD : We employed a program which consists of training based on autobiographical memory , forgiveness and gratitude.
METHOD : We examined166 older persons ( mean age @number@ years , @percent@ women ) enrolled in a prospective aging study.
METHOD : We examined age-related change in aviation performance in aircraft pilots in relation to baseline cognitive ability measures and aviation expertise.
METHOD : We examined attachment anxiety and avoidance in @number@ Internet respondents ( @percent@ female ) ranging in age from @number@ to @number@
METHOD : We examined @number@ healthy adolescents ( 12-14years of age ) with diffusion tensor imaging ( DTI ) .
METHOD : We examined @number@ twins aged 51-59 years when recruited into the Vietnam Era Twin Study of Aging ( VETSA ) .
METHOD : We genotyped @number@ middle-aged healthy women ( @number@ to @number@ years old ) for the COMT Val158Met polymorphism.
Method : We identify the impact of population aging using simulation methods that explain prison growth as the combination of criminal justice processes.
METHOD : We included studies based on PICO questions ( Participant , Intervention , Comparison , Outcome ) describing each of the five specific decision.
METHOD : We make a critical evaluation of the description of personality disorders given in DSM-5.
METHOD : We performed an interventional , prospective , before-after single-center study , approved by a research ethics committee.
METHOD : We presented the collaborative efforts of Italian Reference Site Collaborative Network 2012-2015.
METHOD : We recruited an age-diverse convenience sample of @number@ UK adults.
METHOD : We reviewed the relevant literature on aging , well-being , and wisdom.
METHOD : We sought the published studies of associations between any genetic polymorphism and VaD and critically appraised them.
METHOD : We studied medical students entering the Auckland medical programme from 2006-2008 who completed an entry and exit questionnaire on career intentions.
METHOD : We studied @number@ ACTIVE participants aged @number@ to @number@
METHOD : We studied @number@ elderly from the second wave of the SABE Study in @number@
METHOD : We studied the performance of SIVD patients , healthy young control persons and old control persons in an emotional word list learning task.
METHOD : We surveyed experience in clinical rehabilitation by means of an appropriate literature search.
Method : we systematically searched MEDLINE , CINAHL , AMED and PsycINFO from inception to @date@ .
METHOD : We used a cross-sectional and prospective cohort design to study @number@ caregiver-patient dyads in a home-based primary care program.
METHOD : We used a prospective longitudinal design to examine whether cortisol dysregulation was related to AD risk.
METHOD : We used a structured search of databases to identify original English-language articles.
METHOD : We used in-home unattended polysomnography to measure sleep architecture in older men.
METHOD : We used logistic regression to analyze secondary data regarding @number@ Chinese older adults applying for long-term care service in Hong Kong in @number@
METHOD : We used longitudinal data from the Washington Heights-Inwood Columbia Aging Project ( WHICAP ) .
METHOD : We used @number@ waves of a longitudinal survey from Taiwan ( @number@ @number@ and @number@ ) including @number@ older adults aged 58-74.
METHOD : We used the Indirect-Direct Aggression Questionnaire , which provides response bias and physical , verbal and indirect aggression scores independently of each other.
METHOD : We use time diary data from the @number@ Panel Study of Income Dynamics and Disability and Use of Time supplement.
METHOD : Young and older adults played a computer-based task , Virtual Week , in which they had to remember to carry out life-like intentions.
METHOD : Younger and older adults completed a modified operation span task that varied the number of refreshing opportunities.
Methylation aging as measured by the age acceleration residual increased over the time course of HIV infection ( p = 0.035 ) .
Methylation aging was assessed using the Horvath method.
Methylation and expression of SRD5A2 may be used as a gene signature to tailor therapies for more effective treatment of prostatic diseases.
Methylation at CpG sites is a critical epigenetic modification in mammals.
Methylation at previously reported HIF3A sites correlated significantly with BMI in females only.
Methylation is a prevalent posttranscriptional modification of RNAs.
Methylation is to a large extent influenced by the ageing process , diets and lifestyle choices.
Methylation levels at three age-related CpGs located in the genes ITGA2B , ASPA and PDE4C were subsequently analyzed by bisulfite pyrosequencing of @number@ blood samples.
Methylation of HIST1H4K showed significant correlation with aging ( r = 0.5418 ; p < 0.0001 ) , but with no other clinicopathological characteristics.
Methylation of human genes is strongly associated with cervical intraepithelial neoplasia ( CIN ) and cancer.
Methylation of these fragments is linearly correlated with age over a range of six decades ( r = @number@.80-0.88 ) .
Methylation profiles were obtained using the Illumina Human Methylation450 platform.
Methylation testing is likely to show big improvements in performance in the next @number@ years.
Methylation was assessed in DNA extracted from umbilical cord white blood cells.
Methylene blue ( MB ) is commonly used in diagnostic procedures and is also used to treat various medical conditions.
Methylglyoxal exerts several biological activities.
Methylmercury binds to protein in fish and is therefore not eliminated by cleaning or cooking the fish.
Methylmercury is absorbed in the gastrointestinal tract and crosses the blood-brain barrier and the placenta.
Methylthioninium chloride has previously shown potential efficacy as monotherapy in patients with Alzheimer's disease.
Meticulous perioperative care is important for successful surgery.
Meticulous perioperative management is crucial as older patients with PD may face several surgery-related complications compared to the younger patients.
Metopism is the term used to describe a metopic suture that persists up to the adulthood.
MetS accelerated the age-associated increase in PWV levels at any age , and similarly in men and women.
MetS adversely affects the language performance of older adults , impairing accuracy of both lexical retrieval and sentence processing.
MetS compromised mood , cognition and hippocampal structure with incremental risk applying to some but not all of these outcomes.
MetS had an overall prevalence of @percent@ ( @number@ subjects ) .
MetS has been associated with several chronic diseases in the adulthood ; however , in the recent years , the syndrome was redefined in children.
MetS presence was not found to be associated with the severity of LUTS ( p = 0.144 ) .
MetS risks were also significantly associated with serum fetuin-A in various subgroups of sex , age , body mass index and glycaemic status.
MetSRisk was calculated as the sum of arbitrarily weighted factors positively associated with MetS divided by HDL cholesterol.
MetS was assessed for the years @number@ @number@ and @number@
MetS was assessed using the definition of the US National Cholesterol Education Program.
MetS was defined according to the American Heart Association-National Heart , Lung and Blood Institute-International Diabetes Federation-World Health Organization harmonized criteria.
MetS was defined according to the revised National Cholesterol Education Program's Adult Treatment Panel III ( NCEP ATPIII ) criteria.
MetS was defined by the @number@ harmonizing definition.
MetS was defined by the updated NCEP ATP III criteria.
MetS was defined by using the modified National Cholesterol Education Programme - Adult Treatment Panel III ( NCEP- ATP III ) definition.
MetS was defined in accordance with the ATP III criteria.
MetS was diagnosed according to the criteria of the IDF.
MetS was diagnosed according to the National Cholesterol Education Program's ATP-III criteria.
MetS was present in @percent@ of the participants.
Met to Leu apoA-I variants were used to establish the predominant role of oxidation of Met-86 and Met-148 in the fibril formation process.
Mex have significantly less TASM with greater total and truncal fat.
Mexican-Americans , however , were protected from any deleterious effects of testosterone , potentially due to higher levels of endogenous antioxidant defenses such as GST.
Mexican Americans ( @number@ g ) consumed more fiber than non-Hispanic whites ( @number@ g ) and non-Hispanic blacks ( @number@ g ) .
Mexican-Americans reported sitting less than both non-Hispanic Whites and non-Hispanic Blacks ( all p < 0.0001 ) .
Mexico is undergoing an epidemiologic and demographic transition with increasing obesity rates.
MF- and HF-AUCs tended to show a difference between younger and older age-groups in all @number@ conditions.
Mfn2 exerts its antiproliferative effect by acting as an effector molecule of Ras , resulting in the inhibition of the Ras-Raf-ERK signaling pathway.
Mfn2-knockdown clones of a B-cell lymphoma cell line BJAB exhibited an increased rate of cell proliferation.
MFU-V consistently allows for safe treatment when correct treatment technique is used.
MFV increased during -10° HDT , but not in the other conditions even though blood pressure at the middle cerebral artery ( BPMCA ) increased.
MFV was significantly less in all HDT conditions compared with the control in the first 5-s period of HUT , but it recovered quickly.
MG also reacts with free amino group of nucleic acids resulting in the formation of DNA-AGEs.
MGC803-resistant cells also showed a c-Myc-dependent increase in xenograft growth and telomerase activity in vivo.
MGO was shown to modify proteins and to contribute to the accumulation of damaged proteins that can be toxic to cells.
MG performance suggests that acquisition is impaired in AD patients even at predementia stage ( MCI-AD ) .
MG produced more cross-linking compared to ribose at the same concentrations.
Mg-PSZ exhibited the least variability.
Mgs1 , the yeast homolog of WRNIP1 , may act downstream of ubiquitylation of PCNA to mobilize DNA polymerase δ.
MH at week @number@ predicted clinical remission at week @number@
MHE lessens a patient's quality of life , but is treatable when identified.
MHY336 induced G2 / M or S phase arrest in LNCaP cells through a well-documented topoisomerase II-dependent mechanism.
MHY-449-induced apoptosis was partially prevented by pretreatment with the ERK inhibitor PD98059 suggesting involvement of ERK in the MHY-449-induced apoptosis.
MHY-449 treatment activated extracellular signal-regulated kinase ( ERK ) signaling in a concentration-dependent manner.
MHY-449 treatment in androgen-independent and p53-null PC3 cells resulted in inhibition of cell growth and induction of apoptosis in a concentration-dependent manner.
MI ability was also measured with the Controllability of Motor Imagery Test , in which body parts have to be controlled and manipulated mentally.
Mice administered with tacrine or donepezil displayed lower levels of brain PS1.
Mice are particularly appealing organisms for studies of mammalian aging ; however , epigenetic clocks have thus far been formulated only in humans.
Mice carrying different apoE polymorphisms showed differences in the acquisition and retention of the spatial navigation task both at @number@ and 12months of age.
Mice deficient for Tcad lack tissue-associated Adipo , accumulate Adipo in the circulation , and mimic the Adipo knockout ( KO ) cardiovascular phenotype.
Mice deficient for the chemokine ( C-C motif ) receptor @number@ ( CCR2 ) develop an accelerated Alzheimer-like pathology.
Mice deficient in Mpv17 show signs of premature aging.
Mice deficient in the klotho gene ( kl / kl mice ) display the phenotypes of human ageing.
Mice deficient in Zmpste24 , a metalloproteinase mutated in human progeria and involved in nuclear prelamin A maturation , recapitulate multiple features of ageing.
Mice expressing tau with the P301S mutation showed profound loss of object recognition memory at @number@ months of age.
Mice fed standard chow were used as an additional control.
Mice harboring subcutaneous tumors exhibited elevated levels of DNA damage in distant organs.
Mice in every group were sacrificed after @number@ weeks posttransplantation.
Mice lacking either FGF-23 or Klotho show hyperphosphatemia in addition to developing multiple aging-like phenotypes , which can be rescued by resolving phosphate retention.
Mice lacking SAFB1 exhibit developmental abnormalities in their lungs , high incidence of perinatal lethality , and adults develop different types of tumors.
Mice lacking TAp73 exhibited increased DNA damage and cell death in spermatogonia , disorganized apical ectoplasmic specialization , malformed spermatids , and marked hyperspermia.
Mice preconditioned by voluntary running exhibited a marked reduction in aortic endothelial apoptosis.
Mice were analyzed quarterly for age-related changes in the hematopoietic and immune systems , and followed for periods up to 18-24 months post-transplant.
Mice were immunized intramuscularly with inactivated influenza vaccine with and without the adjuvant MF59 and then challenged with H1N1 influenza.
Mice were immunized with the new monoclonal antibodies 1H7 , 5C1 , or 5D12 , all directed against the CT of α-syn.
Mice were then grouped based on chemotherapy status and GE or control diet.
Mice with global or liver-specific inactivation of the Prkcd gene displayed increased hepatic insulin signaling and reduced expression of gluconeogenic and lipogenic enzymes.
Mice with inactive Poln are fertile and have normal testis morphology.
Michael N. Hall is this year's recipient of the Lasker Basic Medical Research Award for the identification of the target of rapamycin , TOR.
Micheliolide ( MCL ) is a sesquiterpene lactone which inhibits various inflammatory response.
Microalbuminuria ( > 20 mg / g of creatinine ) was detected only in five ELBW children ( p = @number@ ) .
Microalbuminuria is a marker of kidney dysfunction frequently related to an inflammatory event.
Microarray analysis identified mRNA expression of Prdx5 , Vcam1 , CCL20 , Alcam , and Pax6 as being significantly altered by HUCB cell treatment.
Microarray analysis revealed upregulation of AR expression in T24GR cells compared with T24 cells.
Microarray gene expression analysis on leukocytes was performed.
Micro-array studies revealed that the HBL-specific molecular signature is developed in livers of CUGBP1 KO mice at very early ages.
Microarray technology was employed to profile expression of genes related to the identification , growth , and differentiation of stem cells.
Microbes are now linked to fundamental physiological processes , such as aging , based on data from invertebrate systems.
Microbial contamination of the generator pocket and or leads by skin flora at the time of implantation is a major mechanism for early CIED infections.
Microbial sources could be used as a potential means of producing natural antioxidants.
Microbial translocation of gut bacterial components is associated with chronic immune activation and possibly systemic inflammation.
Microbiome's role is increasingly being applied to respiratory diseases , in particular COPD , asthma , cystic fibrosis and bronchiectasis.
Microbleeds also frequently occur in the asymptomatic , general population.
Microbleeds at baseline predicted development of new microbleeds ( OR , @number@ @percent@ CI , @number@ to @number@ ) .
Microbleeds occurred closer within persons than between persons ( @number@ mm , @percent@ confidence interval , @number@ to @number@ p < @number@ ) .
Microcephaly appeared postnatally , was proportionate to height and weight , and did not correlate with severity of ataxia or genotype.
Microcosms were held for a 21-day period and sampled on day @number@ @number@ @number@ @number@ @number@ @number@ and @number@
Microdamage , small crack in bone , is a product of bone fatigue.
Microdermabrasion was performed at point ' @number@ , after @number@ weeks , and after @number@ weeks of treatment.
Microdots are bright , 1-2um features of the cornea.
Microfattransfer can be combined with other cosmetic facial procedures such as blepharoplasties and facelifts.
Microfattransfer is a useful adjunctive procedure in maxillofacial surgery.
Microfattransfer should be considered as a staged treatment modality.
Microglia activation following surgery was positively correlated to parameters of behavior and spatial learning.
Microglia activation ( IBA-1 ) and neurogenesis ( DCX ) were immunohistochemically determined.
Microglia activation is believed to be regulated by the CD200-CD200R signaling.
Microglia and infiltrating monocyte-derived macrophages are now known to be functionally distinct and of separate origin.
Microglia are activated by any type of pathologic event or change in brain homeostasis.
Microglia are essential for CNS homeostasis and innate neuroimmune function , and play important roles in neurodegeneration and brain aging.
Microglia are highly active and vigilant housekeepers of the central nervous system that function to promote neuronal growth and activity.
Microglia are innate immune cells of the brain that mediate responses to pathogens and injury.
Microglia are involved in disease states and normal aging processes of the adult human brain.
Microglia are resident cells of the brain that regulate brain development , maintenance of neuronal networks , and injury repair.
Microglia are resident immune cells that provide continuous surveillance within the brain.
Microglia are the main immune cells of the central nervous system.
Microglia are the prime innate immune cells of the central nervous system.
Microglia are therefore key targets for therapeutic intervention.
Microglia are thought to play important roles in the maintenance of neuronal circuitry and the regulation of behavior.
Microglia can be protective and promote phagocytosis , degradation and ultimately clearance of Aβ , the pathogenic protein deposited in the brains of Alzheimer's patients.
Microglia constitute the resident immunocompetent cells of the central nervous system.
Microglia contribute to development , homeostasis , and immunity of the CNS.
Microglia develop an inflammatory phenotype during normal aging.
Microglia have been implicated in mechanisms of CNS trauma , stroke , infection , demyelination , neoplasm , and neurodegeneration.
Microglia have been reported to degrade and clear β-amyloid , but they also can exert deleterious effects due to overwhelming inflammatory reactions.
Microglia have different functions , neuroprotective or neurotoxic , according to aging in patients with PD.
Microglia , innate immune cells of the CNS , play key roles in mediating these neuroinflammatory responses.
Microglia-involved neuroinflammation is thought to promote brain damage in various neurodegenerative disorders.
Microglial activation can be quantified in vivo using ( R ) - [ ( @number@ ) C ] PK11195 and positron emission tomography.
Microglial activation is one of the hallmarks of the aging brain and coincides with age-related neurodegeneration and cognitive decline.
Microglial and neuronal crosstalk is mediated in part by CX3CL1 / CX3CR1 signaling and a disruption in this pathway has been associated with impaired neurogenesis.
Microglial cell function is implicated in the etiology of Alzheimer's disease by human genetics.
Microglial cell processes were reduced in length , showed less branching and reduced arborized area with aging ( case range 52-98 years ) .
Microglial cells are the immune cells in the CNS and represent approximately @percent@ of the total brain cell population.
Microglial dysfunction may also contribute to genetic neurobehavioral disorders , such as Rett syndrome.
Microglia-like cells exhibited lower expression of CD45 and MHC class II than macrophages , a characteristic similar to brain microglia.
Microglia , the tissue macrophages of the brain , have under healthy conditions a resting phenotype that is characterized by a ramified morphology.
Micro ( mi ) RNAs are regulators of gene expression , which could be involved in neurodegenerative diseases.
Micromorphogical analysis of the treated surfaces was also performed ( atomic force and scanning electron microscopy ) .
Microneedles have been shown to substantially enhance skin penetration and may offer an effective means of peptide delivery enhancement.
Microneedling showed noteworthy results when used on its own and when combined with topical products or radiofrequency.
Micronuclei and comet assays were performed to detect spontaneous DNA damage.
Micronutrient deficiencies and aging process can lead to genomic instability.
Micronutrient deficiency is explored and evidence-based supplementation discussed.
Micronutrient requirements as aging advances could change , and require due attention.
Micronutrients from the diet and gut microbiota are essential to human health and wellbeing.
Micronutrients ( vitamins , trace-elements and also antioxidants ) most likely affect brain integrity by normalizing efficient autophagy.
Microoxygenation ( MOX ) is now widely applied for the maturation of red wines as an alternative to barrel aging.
Microparticles are formed in stored pRBCs over time and have been shown to contribute to lung inflammation after transfusion.
Microperimetry showed stable central fixation with recovery of retinal sensitivity within the central @number@ degrees.
Microperimetry was useful to explain vision improvement despite residual macular hole.
Microphotographs and scanned sections immunostained for phosphorylated tau ( AT8 ) were made available for download and preview.
Microphthalmos is a rare congenital anomaly characterized by reduced eye size and visual deficits of variable degree.
Microrelief was included in the model to assess its effect on the mechanism.
MicroRNA-122 ( miR-122 ) plays an important role in the regulation of liver metabolism , but its intrinsic physiological functions require further clarification.
MicroRNA-132 is markedly downregulated in Alzheimer's disease ( AD ) and related tauopathies , and its levels are closely associated with tau pathology in AD.
Micro-RNA-495 was known to be upregulated in the MSCs derived from patients with PE.
MicroRNA analysis was performed in CCL5-treated chondrosarcoma cells versus control cells to investigate the mechanism of CCL5-mediated promotion of chondrosarcoma angiogenesis.
MicroRNA microarray and subsequent validation by RT-PCR showed a significant upregulation of ABCA1-linked miR-758 and miR-33b in plaques from hypercholesterolemic patients.
MicroRNA ( miR ) are small non-coding RNAs that inhibit gene expression by binding to complementary sequences in the @number@'UTR of their target mRNAs.
MicroRNA ( miR ) has been implicated as a key regulator controlling diverse biological processes through posttranscriptional repression.
MicroRNA ( miRNA ) is thought to be involved in cardiovascular regulation.
MicroRNA ( miRNA ) profiling has become widely used to identify biomarkers and therapeutic targets.
MicroRNA @number@ expression was decreased independent of the training modality , and was paralleled by an increased expression of IGF-1 representing a potential target.
MicroRNA profiling revealed upregulated miR-375 in DOX-induced senescent K562 cells.
MicroRNAs are a group of small RNAs that regulate diverse cellular processes including neuronal function.
MicroRNAs are emerging as pivotal players linking ageing and cancer.
MicroRNAs are important posttranscriptional regulators of gene expression.
MicroRNAs are non-coding RNAs with roles in many cellular processes.
MicroRNAs are posttranscriptional regulators of gene expression.
MicroRNAs can influence the expression of hundreds of genes and thus could regulate gene assemblies during processes like activity-dependent integration.
MicroRNAs constitute a complicate network that can adjust at a variety of external environmental stimuli.
MicroRNAs control gene expression at a posttranscriptional level.
MicroRNAs emerged as powerful and dynamic modifiers of cardiovascular diseases.
MicroRNAs have emerged as important regulators of cellular functions and can be modified by diet.
MicroRNAs have emerged as major regulators of almost every gene associated with cancer , aging , and related pathologies.
MicroRNAs ( miRNAs ) are believed to play important roles in the regulation of cell death and proliferation during the aging process.
MicroRNAs ( miRNAs ) are cellular , short , non-coding ribonucleotides acting as endogenous posttranscriptional repressors following incorporation in the RNA-induced silencing complex.
MicroRNAs ( miRNAs ) are expected to participate in this molecular network.
MicroRNAs ( miRNAs ) are found in the circulatory biofluids considering the important molecules for biomarker study in aging and age-related diseases.
MicroRNAs ( miRNAs ) are key regulators of aging and cellular senescence in eukaryotes.
MicroRNAs ( miRNAs ) are novel posttranscriptional modulators of gene expression with potential roles as regulators of skeletal muscle mass and function.
MicroRNAs ( miRNAs ) are one class of endogenous non-coding RNAs that involved in post-transcriptional regulation of the gene.
Micro-RNAs ( miRNAs ) are responsible for important and evolutionary-conserved regulatory functions in several cellular processes such as apoptosis , signalling , differentiation and proliferation.
MicroRNAs ( miRNAs ) are small , noncoding RNAs that function in complex networks to regulate protein expression.
MicroRNAs ( miRNAs ) are small noncoding RNAs that post-transcriptionally regulate gene expression by targeting specific mRNAs.
MicroRNAs ( miRNAs ) are small non-coding RNAs that regulate gene expression.
MicroRNAs ( miRNAs ) have emerged as important regulators of tumorigenesis.
MicroRNAs ( miRNAs ) play important roles in the initiation and progression of a multitude of tumors.
MicroRNAs ( miRNAs ) regulate gene expression with emerging data suggesting miRNAs play a role in skeletal muscle biology.
MicroRNAs ( miRNAs ) regulate many important biological processes.
MicroRNAs ( miRNAs ) regulate various aspects of development and metabolism , and one miRNA has been previously implicated in life span.
MicroRNAs play an important role in regulation of gene expression , but still detection of their targets remains a challenge.
MicroRNAs reflect individual biologic adaptation to exposures in the environment.
MicroRNAs regulate various processes associated with cell senescence ; differentiation , replication and apoptosis.
MicroRNAs were profiled in early and late passage primary lung and skin fibroblasts to identify commonly-deregulated miRNAs.
Micro-RNA therapies for cancer are already being tested in clinical phase trials.
Microsatellite analysis indicated that the ciPSCs showed the same profile as the donor fibroblasts but differed from cells taken from other dogs.
Microsatellite expansion disorders are pathologically characterized by RNA foci formation and repeat-associated non-AUG ( RAN ) translation.
Microsatellite instability was analyzed using a mononucleotide marker panel.
Microscopic examination of the lactophenol cotton blue stained mold colonies indicated long conidiophores with vesicles surrounded by uniseriate phialides , compatible with Aspergillus flavus.
Microscopic examinations also either misdiagnosed the infected Plasmodium species , or did not detect mixed infections with different Plasmodium species in @number@ cases.
Microsimulation measured outcomes.
Microstructural abnormalities on DTI are promising in vivo biomarkers of gray and white matter changes associated with the progression of AD pathology.
Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.
Microstructural white matter measures were derived using diffusion tensor imaging ( DTI ) analyses on the diffusion-weighted imaging ( DWI ) sequence.
Microstructured and mechanically-tailored hydrogels supported the growth of human mesenchymal stem cells and led to higher osteopontin expression in comparison to their non-tailored counterparts.
Microsurgical resection can be safe and effective for selected patients.
Micro-tensile bond strength and degradation of collagen were tested before , and after @number@ month or @number@ months of aging in artificial saliva.
Microtensile bond strengths were determined.
Microtubule-associated protein tau ( MAPT ) mutations have been shown to underlie frontotemporal dementia and a variety of additional sporadic tauopathies.
Microtubule associated protein tau ( tau ) deposition is associated with a spectrum of neurodegenerative diseases collectively termed tauopathies.
Microtubule disruption or co-transfection with α-synuclein A53T , a PD-associated mutation , caused TH1-S31E accumulation in the cell soma.
Microtubules are key cytoskeletal elements found in all eukaryotic cells.
Microvascular free tissue transfer can be performed with a high degree of security in selected elderly patients.
Microvesiculation , percentage of haemolysis and haematologic parameters were also evaluated.
Mid-adulthood hypertension was associated with @percent@ ( @percent@ confidence interval [ CI ] @number@ @date@ ) increased dementia risk among women but not men.
Mid-career workers could fare better because they have more time to rebuild their wealth.
Mid- @date@ , the patient died after a profound unconsciousness due to hypoglycaemia with hypothermia.
Middle-aged adults ( aged 40-64 ) generally performed as well as the younger adults ( aged 18-39 ) .
Middle-aged adults also showed a greater shift in their point of subjective simultaneity than young adults.
Middle-aged adults may treat support of parents as more discretionary , with cultural ideas about obligation and personal rewards guiding behaviors.
Middle-aged and elderly women constitute a large and growing proportion of the population.
Middle-aged and old adults both found the task challenging , and force steadiness even worsened for old adults after practising the co-contraction task.
Middle-aged and older men and women [ n = @number@ aged @number@ ± 7 ( SD ) yr ] underwent IWT.
Middle-aged fibromyalgia subjects had a significant viscous stiffness increase of @number@ times that of controls ( P = @number@ ) .
Middle-aged people have shown a high fall incidence and degeneration in gait stability , while few studies concern that.
Middle-aged , working- and middle-class people in urban Northern Thailand are using demographic categories to imagine their future identities as ' senior citizens'.
Middle age in particular has been largely understudied , and investigating this period of the lifespan may be especially important for our understanding of senescence.
Middle age is associated with a pronounced decline in power and flexibility.
Middle aortic syndrome ( MAS ) is a narrowing of the abdominal aorta , often in conjunction with renal artery stenosis ( RAS ) .
Middle cerebral artery blood flow velocity was assessed bilaterally during normocapnia and hypercapnia ( @percent@ CO2 ) .
Middle-income countries will face workforce shortages because their demand will exceed supply.
Midface descent further drags this intersection inferiorly , leading to a vertically lengthened lower eyelid.
Midfacial aging is a multifactorial , 3-D process that involves volume loss , volume descent , and skin alterations.
Midlands region will be the most expensive of the eight old health board regions.
Midlife hypertension is especially strongly associated with a greater risk of vascular dementia , regardless of late-life blood pressure levels.
Midlife memory change did not predict total hippocampal volume for those currently in late middle age ( age 52-65 ) .
Midlife negative and positive aspects of close relationships were assessed twice using the Close Persons Questionnaire during the @number@ years preceding cognitive assessment.
Mid-life occupational complexity was also associated with more favourable trajectories but not with mortality risk.
Mid-life proteinuria was detected by urine dipstick in @number@ to @number@
Mid-life psychological stress , psychosocial stress and post-traumatic stress disorder have been shown to cause cognitive dysfunction and lead to increased risk for dementia.
Mid-life SES was defined by education and major mid-life occupation of the participant and / or their partner.
Mid membranous vocal fold slides were subjected to immunohistochemical reactions.
Midpupil lid distances and angles of the medial and lateral canthal ends were also analyzed , and the palpebral fissure inclination was measured.
Mid-sagittal sections were immunostained for endothelial cell marker PECAM-1.
Mid-spinal canal diameter was not affected by aging.
Mid-term outcomes showed maintenance of the minimal required ADL and good motivation for living.
( MIDUS ) study.
( MIDUS ) study , aged 25-74.
Midvaginal bacterial community composition was characterized by 16S ribosomal RNA gene analysis.
Mieap expression is directly regulated by p53 and is frequently lost in human cancer as result of DNA methylation.
MIF levels increased during TT versus ST + placebo.
Might they be discriminated as non pathological in assessing patients ' competence and how ?
Migraine undergoes both an evolving state in the formative years but also has a remitting state which bears resemblance to the former.
Migrant families undoubtedly face a special situation as values and expectations from the culture of origin and from the host cultural context might differ.
Migrants who can self-determine their place of resettlement have more favorable outcomes than others.
Migrant workers and the elderly were repeatedly documented as the main obstacles in effective tuberculosis control in the county.
Migrated cells were positive for mature macrophage marker PM-2K , indicating the transformation of monocytes into macrophages.
Migration and invasion of PC-3 and PC-3 ( AR ) cells were promoted by EGF or IGF-1 but were suppressed by Casodex.
Migration of CECs across the RPE was determined using fluorescence microscopy.
Migration of keratinocytes to re-epithelialize wounds is a key step in dermal wound healing.
Migration , tube formation , and CCK-8-induced proliferation assays were used to test the effect of the miRNAs on phenotypic properties of AVMSMCs.
Migration was blocked by aromatase and steroid sulfatase ( STS ) inhibitors confirming intracrine synthesis to estrogen.
MI index and SC and D values increased while EI index and TEWL values decreased after the treatment.
MI inflated MMSE scores , but differences between those imputed and those without missing data still existed.
Mild action tremor occurs in most normal people.
Mild bruising , tenderness , asymmetry , and blepharoptosis were also noted , but no additional treatments were necessary.
Mild cases presented a @number@ % mortality , while @number@ % of severe cases died.
Mild cognitive changes ( especially executive dysfunction ) have been documented in many studies as well.
Mild Cognitive Impairment groups and normals did not differ suggesting visuospatial processes are not affected early in the dementing process.
Mild Cognitive Impairment is a syndrome that appears to capture a group of individuals in a transitional state between normal aging and dementia.
Mild cognitive impairment is the term applied to the cognitive state that lies between normal aging and dementia.
Mild cognitive impairment ( MCI ) , Alzheimer disease , and related dementias are a global health problem.
Mild cognitive impairment ( MCI ) and healthy aging have been shown to be associated with mild parkinsonian signs ( MPS ) .
Mild cognitive impairment ( MCI ) can be a stage of pre-dementia.
Mild cognitive impairment ( MCI ) can be considered as an intermediate stage between normal cognitive aging and dementia.
Mild cognitive impairment ( MCI ) has been considered an intermediate state between healthy aging and dementia.
Mild cognitive impairment ( MCI ) has been described as an intermediate stage between normal aging and dementia.
Mild cognitive impairment ( MCI ) is a construct originally proposed to identify those who fall between normal cognitive aging and dementia.
Mild cognitive impairment ( MCI ) is a neurological condition related to early stages of dementia including Alzheimer's disease ( AD ) .
Mild cognitive impairment ( MCI ) is an intermediate stage between normal aging and dementia.
Mild cognitive impairment ( MCI ) is an intermediate stage between normal cognitive function and dementia among aging individuals.
Mild cognitive impairment ( MCI ) is a nosological entity proposed as an intermediate state between normal aging and dementia.
Mild Cognitive Impairment ( MCI ) is a syndrome characteristic of early stages of many neurodegenerative diseases.
Mild cognitive impairment ( MCI ) is a transitional stage between age-related cognitive decline and Alzheimer's disease ( AD ) .
Mild cognitive impairment ( MCI ) is considered as a transition phase between normal aging and Alzheimer's disease ( AD ) .
Mild cognitive impairment ( MCI ) is often associated with the preclinical phase of Alzheimer's disease ( AD ) .
Mild cognitive impairment ( MCI ) is often considered to be a transitional stage between normal aging and dementia.
Mild cognitive impairment ( MCI ) is routinely diagnosed with the aid of neuropsychological tests , which do not tap the ABM and PSM domains.
Mild cognitive impairment was more often associated with poor PWB , whereas moderate or severe impairment was more often associated with good PWB.
Mild dementia severity increased the use of AChEIs , and moderate-advanced dementia increased the likelihood of memantine consumption.
Mild erythema observed post-treatment was resolved by the 6-week follow-up visit in all subjects.
Mild hearing impairment was not associated with level of physical activity.
Mildly reduced eGFR was prevalent among @percent@ ( n = @number@ ) .
Mild or moderate frailty is potentially reversible with an individualised caring plan.
Mild or transient oxidative stress up-regulates the ubiquitination system and proteasome activity in cells and tissues and transiently enhances intracellular proteolysis.
Mild parkinsonian signs ( MPS ) may represent the mild end of a disease spectrum that spans from normal aging to neurodegenerative diseases.
Mild parkinsonian signs were defined as the presence of bradykinesia , rigidity and / or rest tremor.
Mild peeling was the most common adverse event.
Mild postnatal renal dilatation is associated with subsequent UTI or renal tract abnormality in @percent@.
Mild SBP control benefitted subjects in all age ranges over @number@ years.
Mild soluble β-amyloid accumulation can result in reduced membrane ( functional ) and elevated cytosolic levels of GRK5.
Mild sunken upper eyelids were corrected during upper blepharoplasty by exposing the central orbital fat sac and transposing it in a flap-like manner.
Mild swelling at the insertion points and general treatment area resolved within @number@ days without intervention.
Mild TBI was not associated with worse motor function.
Mild-to-moderate cognitive limitations do not hinder clients from coping semi-independently with routine requirements.
Mild to moderate hyperprolinemia is a significant risk factor for schizophrenia , and may represent an intermediate phenotype in the disease.
Milk contains calcium , phosphorus , and protein and is fortified with vitamin D in the United States.
Milling in the presintered state resulted in less variability than milling in the HIPed state.
Millions are rendered blind or exhibit visual impairment due to pathologies of the lens of the eye.
Millions of blood products are transfused every year ; many lives are thus directly concerned by transfusion.
Millions of patients are hospitalized for acute heart failure ( AHF ) every year throughout the world.
Milrinone inhibits PDE III , increasing the availability of cAMP.
Mindful decisions about antibiotic use will require a far better understanding of how pathogenicity arises within microbial communities.
Mindfulness-based stress reduction ( MBSR ) and exercise have been shown to affect aspects of immune function in some populations.
Mindfulness-based stress reduction ( MBSR ) reduces symptoms of depression , anxiety , and fear of recurrence among breast cancer ( BC ) survivors.
Mineral intakes were calculated and compared to recommended standards.
Mineral trioxide aggregate ( MTA ) and calcium hydroxide ( Dycal ) served as commercial controls.
Minicolumn changes were correlated with premortem cognitive scores ( mini-mental state examination and verbal fluency ) .
Minimal age- and AD-related changes in GWIR were observed.
Minimal and reversible adverse side effects and rapid healing were noted.
Minimal changes were observed for water-handling properties.
Minimal hepatic encephalopathy ( MHE ) is a metabolic brain disorder occurring in patients with liver cirrhosis.
Minimal information was identified to suggest the ideal scheduling of a delirium assessment process to maximize the recognition of this condition in the ED.
Minimally ablative fractional laser devices have gained acceptance as a preferred method for skin resurfacing.
Minimally invasive cosmetic procedures are being performed at increasing rates.
Minimally invasive injectable esthetic treatments have become a popular treatment choice in our society.
Minimally invasive procedures are more acceptable in this population , since they reduce surgical morbidity and the risk of complications.
Minimally invasive procedures have become increasingly popular over the last decade.
Minimally invasive surgery and restoration of vitreous structure warrant further attention as strategies for preventing nuclear cataracts.
Minimal MMP-1 and MMP-9 expression was recorded even in grades III-IV photoaging and in the foci of actinic keratosis.
Mini Mental State Examination and Clinical Dementia Rating scales were also administered at baseline and each follow-up timepoint.
Mini-Mental State Examination ( MMSE ) scores were performed for all subjects to evaluate cognitive functions.
Mini-Mental State Examination ( MMSE ) was performed for all of the subjects.
Mini-Mental State Examination ( MMSE ) was used to assess cognitive function by trained neurology doctors.
Mini Mental State Examination scores did not decline after treatment , even in AD patients.
Mini-Mental State Examinations ( MMSE ) were administered to all subjects , and MMSE scores were used to evaluate cognitive function.
Mini-Mental State Examinations ( MMSE ) were administered to all subjects , and MMSE scores were used to measure cognitive functions.
Minimizing adverse effects from this testing will be essential for clinical practice.
Minimizing anticholinergic burden should result in maintaining daily functioning , especially in a vulnerable population , such as MCI and mild AD.
Minimizing negative social support and maximizing positive spousal support can reduce depression caused by MCC and lead to successful aging among older adults.
Minimum-toe-clearance ( MTC ) above the walking surface is a critical representation of toe-trajectory control due to its association with tripping risk.
Mini-nutritional assessment , activity of daily living , geriatric depression scale questionnaires were administered.
Minitab factorial analysis identified several antiviral genes that are influenced by age , infection , and a combination of both factors.
Minor allele frequencies of the highly polymorphic coding single nucleotide polymorphisms ( SNPs ) in PD patients and control subjects were similar.
Minor alterations occurred with aging : SPV shifted backward with increasing age , and the variability of verticality estimates increased.
Minor cervical traumas , infection , migraine and hypertension are putative risk factors , and inverse associations with obesity and hypercholesterolemia are described.
Minor changes were found in relation to aging.
Minor depressive disorder was only associated with worse executive function in younger adults.
Minorities and the poor continue to bear the disproportionate burden of cancer , especially in terms of stage at diagnosis , incidence , and mortality.
Minorities wanted more days of life than Caucasians but only if they believed that they would be paroled.
Minority elderly are overrepresented in facilities and underrepresented in alternative living settings.
Minority inmates desired cardiopulmonary resuscitation or feeding tubes only if they believed that they would be paroled.
Minute variations due to oxidation of single residues affect HSA tertiary structure leading to protein compaction , increased thermal stability , and reduced association propensity.
MIP and MIP percentage decreased significantly with age ( P < @number@ for both ) .
Mir-146a and mir-149 SNP do not play a role in lung cancer risk.
MiR-217 directly targeted the @number@'-untranslated region ( @number@'-UTR ) of DNMT1 in HEK 293T cells and inhibited DNMT1 expression in fibroblasts.
MiR-217 is predicted to target DNMT1 mRNA and miR-217 expression increased in passage-aged fibroblasts.
MiR-217 overexpression induced a senescence phenotype in young fibroblasts , and miR-217 downregulation in old HSFs partially reversed the senescence phenotype.
MiR-21 expression in cartilage specimens was examined in @number@ patients with knee osteoarthritis and @number@ traumatic amputees.
MiR-92a was significantly upregulated in CRC patients in two of the plasma-based studies and in CRC tissue in one of the tissue-based studies.
MiRNA profiles were determined from vastus lateralis muscle of nine healthy 54-62-years-old monozygotic female twin pairs discordant for HRT ( median @number@ years ) .
MiRNAs are fine-tuning modifiers of skeletal muscle regulation , but knowledge of their hormonal control is lacking.
MiRNAs are potent intracellular posttranscriptional regulators and are also selectively secreted into the circulation in a cell-specific fashion.
MiRNAs differentially responded to RT ; muscle miR-133b decreased , while all plasma miRNAs tended to increase.
MiRNAs may act as an oncogene or a tumor suppressor via up or down regulation in cancerous cells.
Mirror-style response was correlated with ToM performance after controlling for language ability , but not after controlling for age.
MiRs modulate a variety of biological functions such as cell development , cell differentiation , and apoptosis.
Misclassifications of drivers totaled @number@ for the UFOV RI , @number@ for Trails B , and @number@ for UFOV Subtest @number@
Misdiagnosed NPC patients were not present in our samples.
Misdiagnosis was significantly associated with the incidence of DKA.
Misexpression of let-7 microRNAs in NPCs reduced proliferation and inhibited neuronal differentiation , phenocopying the loss of SOX2.
Misfolded and damaged proteins are removed from the cells to avoid toxicity.
Misfolded protein in the amygdala is a neuropathologic feature of Alzheimer disease and many other neurodegenerative disorders.
Misfolded proteins are at the core of many neurodegenerative diseases , nearly all of them associated with cognitive impairment.
Misfolded proteins can be toxic and interfere with normal cellular functions , particularly during proteotoxic stress.
Misfolded proteins ( MP ) are a key component in aging and associated neurodegenerative disorders.
Misfolded proteins that cannot be refolded by chaperone machineries are degraded by specialized proteolytic systems.
Misfolding of @number@ protein in aged brains often is accompanied by the misfolding of other proteins , suggesting synergistic mechanisms.
Misfolding of tau protein appeared to occur in situ inside synaptic terminals , without mislocalizing or mistrafficking.
Mislocalization of ß1-integrin , reductions in fibronectin , and alterations in heparan sulfate content all contribute to reduced FGF responsiveness in satellite cells.
Mismanagement of its cellular pools , however , can result in oxidative stress and damage connected to aging , neurodegenerative diseases , and metabolic disorders.
Mismanagement of protein folding and function triggered by genetic , epigenetic and environmental causes poses a major challenge to human health and lifespan.
Misregulation of AD genes has been found to either increase AD risk or accelerate the disease progression.
Mis-regulation of PCD is increasingly implicated in aging and aging-related disease.
Missense mutations are able to form the CST complex at telomeres , but their expression levels are often repressed by the frameshift mutants.
Missense mutations in the human Ant1 cause several degenerative diseases which are commonly manifested by fractional mtDNA deletions.
Missense mutations were detected in @percent@ of index cases and associated with milder forms of the disease.
Missing body size parameters were estimated using simulations from the Simcyp Simulator @date@ for an age and ethnically appropriate population.
Missing data were imputed.
Missing data were replaced using multiple imputation , allowing for a complete dataset ( N = @number@ ) at each wave.
Missing item-level data are commonly reported.
MIs were ascertained from national registries until @date@ .
Mitochondria also play a role in many other essential cellular processes including metabolite synthesis and calcium storage.
Mitochondria also represent a unique system of mitochondrial-nuclear genomic cooperation.
Mitochondria and chloroplasts possess their own repair processes.
Mitochondria are also the major target of ROS.
Mitochondria are a major source of cellular oxidants and have been implicated in aging and associated pathologies , notably cardiovascular diseases.
Mitochondria are both the main source and targets of detrimental reactions initiated in association with age-dependent deterioration of the cellular functions.
Mitochondria are central organelles for cellular metabolism.
Mitochondria are central players in the regulation of cell homeostasis.
Mitochondria are coming to be recognized as a major target for these compounds , especially redox-active ones , but the mechanisms involved still need clarification.
Mitochondria are considered to have originated from the symbiotic invasion of bacteria with aerobic ATP production into pro-eukaryotic cells about two billion years ago.
Mitochondria are critical components in hearing.
Mitochondria are cytoplasmic organelles containing their own multi-copy genome.
Mitochondria are cytoplasmic organelles responsible for life and death.
Mitochondria are cytosolic organelles essential for generating energy and maintaining cell homeostasis.
Mitochondria are double-membrane-bound organelles that are responsible for the generation of most of the cell's energy.
Mitochondria are dynamic organelles surrounded by two membranes with a defined lipid composition.
Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids.
Mitochondria are eliminated via mitochondrial autophagy or mitophagy.
Mitochondria are essential cytoplasmic organelles , critical for cell survival and death.
Mitochondria are essential for mammalian and human cell function as they generate ATP via aerobic respiration.
Mitochondria are essential organelles and consequently proper expression and maintenance of the mitochondrial genome are indispensable for proper cell function.
Mitochondria are essential organelles whose biogenesis , structure , and function are regulated by many signaling pathways.
Mitochondria are highly dynamic organelles and their proper function is crucial for the maintenance of cellular homeostasis.
Mitochondria are highly dynamic organelles that undergo frequent fusion and fission.
Mitochondria are implicated in a variety of degenerative disorders and aging.
Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis.
Mitochondria are important intracellular organelles that produce energy for cellular development , differentiation , and growth.
Mitochondria are important regulators of cellular function and survival that may have a key role in aging-related diseases.
Mitochondria are intracellular organelles involved in ATP synthesis , apoptosis , calcium signaling , metabolism , and the synthesis of critical metabolic cofactors.
Mitochondria are known to be functional organelles , but their role as a signaling unit is increasingly being appreciated.
Mitochondria are not only ATP producing organelles , but they play pivotal roles in apoptosis , neurodegeneration , cancer and aging.
Mitochondria are organelles playing pivotal roles in a range of diverse cellular functions , from energy generation to redox homeostasis and apoptosis regulation.
Mitochondria are referred to as the powerhouse of the cell through their role in the oxidative phosphorylation to generate ATP.
Mitochondria are related to the life and death of cells.
Mitochondria are the main pool of ROS production and act as the key organelles in modulating intracellular redox homeostasis.
Mitochondria are the oxygen-consuming power plants of cells.
Mitochondria are the powerhouse of the eukaryotic cell through their use of oxidative phosphorylation to generate ATP.
Mitochondria are the prime source of ATP in cardiomyocytes.
Mitochondria as a central component of the cellular metabolism play a key role in this adaptive process.
Mitochondria contain their own DNA ( mtDNA ) with genomic variants that have different physiological and pathological characteristics , including susceptibility to neurodegeneration.
Mitochondria drive apoptosis by releasing pro-apoptotic proteins that promote caspase activation in the cytosol.
Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular , metabolic and cardiovascular diseases.
Mitochondria exert crucial physiological functions that create complex links among nutrition , health , and disease.
Mitochondria form a dynamic membrane network that is reshaped by fusion and fission events.
Mitochondria form dynamic networks which adapt to the environmental requirements of the cell.
Mitochondria from Shh-treated neurons were more electron-dense , as revealed by electron microscopy , and had higher membrane potential and respiratory activity.
Mitochondria fulfill a number of biological functions which inherently depend on ATP and O2 ( -• ) / H2O2 production.
Mitochondria govern many metabolic processes.
Mitochondria grow , divide , and fuse in cells.
Mitochondria have a pivotal role in generating cellular oxidative stress , and mitochondrial dysfunction has been associated with several diseases.
Mitochondria have a unique genetic system , mitochondrial DNA ( mtDNA ) , which is a small , self-replicating and diverse genome.
Mitochondria have been implicated in the ageing process and the lifespan modulation of model organisms.
Mitochondria have been in the focus of oxidative stress and aging research for decades due to their permanent production of ROS during the oxidative phosphorylation.
Mitochondria is also affected by sexual hormones that suffer drastic changes during ageing.
Mitochondrial aconitase ( ACO2 ) is a Krebs cycle enzyme sensitive to free radical-mediated damage.
Mitochondrial aging captures the essence of the systemic aging which must be analyzed.
Mitochondrial alterations were not observed in the brain , a tissue with extremely low progerin expression that seems to be unaffected in HGPS.
Mitochondrial and bioenergetic changes are also documented in various age-related neurodegenerative diseases , including Alzheimer's disease ( AD ) .
Mitochondrial and bioenergetic dysfunction could , therefore , link neurodegeneration to brain aging.
Mitochondrial and bioenergetic function change with advancing age and may drive aging phenotypes.
Mitochondrial , and more specifically bioenergetic , malfunction is commonly encountered in cancer , degenerative disorders and aging.
Mitochondrial biogenesis and mitophagy are two pathways that regulate mitochondrial content and metabolism preserving homeostasis.
Mitochondrial Ca ( 2 + ) levels following CPA-induced ER depletion were significantly ( p < .05 ) diminished in TRPC1-silenced Huh7 cells.
Mitochondrial content ( citrate synthase ) was higher ( p < @number@ ) in lean controls than in patients and obese controls.
Mitochondrial content was determined using transmission electron microscopy imaging and OXPHOS was determined as the maximal coupled respiration in permeabilized fibres.
Mitochondrial deficits have been previously assessed in brain from both human autopsy tissue and disease-relevant transgenic mice.
Mitochondrial-derived peptides ( MDP ) are encoded by functional short open reading frames in the mitochondrial DNA ( mtDNA ) .
Mitochondrial diseases can be hard to diagnose and treat and , therefore , interdisciplinary research and communication are important.
Mitochondrial diseases often exhibit tissue-specific pathologies , but this phenomenon is poorly understood.
Mitochondrial division is critical for the maintenance of the structure and function of mitochondria.
Mitochondrial DNA is circular and is inherited maternally.
Mitochondrial DNA ( mtDNA ) clearly requires topoisomerase activity for transcription and replication , because it is a closed , double-stranded DNA molecule.
Mitochondrial DNA ( mtDNA ) content plays an important role in energy production and sustaining normal physiological function.
Mitochondrial DNA ( mtDNA ) encodes proteins essential for ATP production.
Mitochondrial DNA ( mtDNA ) is believed to be highly vulnerable to age-associated damage and mutagenesis by reactive oxygen species ( ROS ) .
Mitochondrial DNA ( mtDNA ) is more vulnerable to reactive oxygen species.
Mitochondrial DNA ( mtDNA ) mutates much faster than nuclear DNA.
Mitochondrial DNA ( mtDNA ) mutations and oxidative stresses are known to contribute to aging-related changes.
Mitochondrial DNA ( mtDNA ) mutations are causatively associated with photo-ageing and are used as biomarkers of UV exposure.
Mitochondrial DNA ( mtDNA ) mutations cause neurological and multisystem disease.
Mitochondrial DNA ( mtDNA ) presents a 10- to 20-fold higher susceptibility to genetic mutations owing to the lack of introns and histone proteins.
Mitochondrial dynamics is a key process regulating mitochondrial function and quality.
Mitochondrial dysfunction and DNA damage is intimately connected to ageing and neurodegeneration , including Alzheimer's disease ( AD ) .
Mitochondrial dysfunction and impairment of the ubiquitin proteasome system have been described as two hallmarks of the ageing process.
Mitochondrial dysfunction and oxidative stress are thought to play important roles in mammalian aging.
Mitochondrial dysfunction elicited by somatic mutations in mtDNA could induce apoptosis in aging cells and some cancer cells with severe mtDNA mutations.
Mitochondrial dysfunction has been implicated in cellular senescence in general and ovarian aging in particular.
Mitochondrial dysfunction has been observed to be an important hallmark of aging and cancer.
Mitochondrial dysfunction has been widely reported in psychiatric and neurodegenerative diseases.
Mitochondrial dysfunction has long been associated with the aging process and the onset of numerous diseases.
Mitochondrial dysfunction has previously been implicated in an array of neurodegenerative disorders.
Mitochondrial dysfunction has severe cellular consequences and is linked with neurodegenerative diseases and aging.
Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of disorders.
Mitochondrial dysfunction is a common hallmark of ageing-related diseases involving neurodegeneration.
Mitochondrial dysfunction is a hallmark of aging and numerous human diseases , including Parkinson disease ( PD ) .
Mitochondrial dysfunction is a hallmark of multiple metabolic complications.
Mitochondrial dysfunction is associated with age-related degenerative diseases.
Mitochondrial dysfunction is implicated in neurodegeneration and ageing.
Mitochondrial dysfunction is implicated in skeletal muscle atrophy and dysfunction with aging , with strong support for an increased mitochondrial-mediated apoptosis in sedentary rodent models.
Mitochondrial dysfunction is implicated in the pathological mechanism of Alzheimer's disease ( AD ) .
Mitochondrial dysfunction is involved in the loss of muscle featuring both aging and cancer cachexia ( CC ) .
Mitochondrial dysfunction is involved in the pathology of Parkinson's disease , an age-associated neurodegenerative disorder.
Mitochondrial dysfunction is linked to a range of pathologies , including cancer , neurodegenerative disorders , premature aging , diabetes and muscular diseases.
Mitochondrial dysfunction may contribute to age-associated muscle atrophy.
Mitochondrial dysfunction plausibly underlies the aging-associated brain degeneration.
Mitochondrial dysfunction plays a key role in ALS disease progression and has been observed in several ALS cellular and animal models.
Mitochondrial dysfunction was reduced in TauXDrp1 + / − mice relative to Tau mice.
Mitochondrial enzymes monoamine oxidases were thought to be an emerging and useful therapeutic target for neurodegenerative disorders.
Mitochondrial expression of Nox4 is upregulated by cardiac stress and aging in the heart , where Nox4 could become a major source of oxidative stress.
Mitochondrial function and cell viability were maintained in AD neurons treated with DDQ.
Mitochondrial function and mtDNA integrity are closely related.
Mitochondrial function has also been linked to the aging process , but the relevant mitochondrial signals mediating the effects of mitochondria are poorly understood.
Mitochondrial function is altered with age and variants in mitochondrial DNA ( mtDNA ) modulate risk for several age-related disease states.
Mitochondrial function was evaluated by analyzing the mitochondrial membrane potential ( Δψm ) with flow cytometry using the fluorofore DePsipher.
Mitochondrial function was maintained in the SS31-treated APP mice over the @number@ weeks of SS31 treatment compared with mitochondrial function in the untreated APP mice.
Mitochondrial fusion and fission affect the distribution and quality control of mitochondria.
Mitochondrial genes including Mfn2 are at the center of many diseases , underscoring their potential as a therapeutical target.
Mitochondrial homeostasis is critical for tissue health , and mitochondrial dysfunction contributes to numerous diseases , including heart failure.
Mitochondrial import terminates the cholesterol mobilization activity of StAR and leads to mounting accumulation of StAR in the mitochondrial matrix.
Mitochondrial malfunction appears to be intimately associated with age and age-related complex disorders but the precise pathological relevance of such malfunction remains unclear.
Mitochondrial mass was increased in the synovium of oligomycin-injected joints , as well as cellular and mitochondrial ROS production , and 4-HNE.
Mitochondrial mass was increased significantly in neurons treated with Shh.
Mitochondrial membrane potential was examined by tetramethylrhodamine methyl ester ( TMRM ) staining.
Mitochondrial membranes possess characteristic lipid compositions that are intimately associated with mitochondrial architecture and activities.
Mitochondrial metabolism appears critical to sustain cardiac function to counteract aging.
Mitochondrial morphology was analyzed by following the localization of the mito-GFP protein into the mitochondrial matrix.
Mitochondrial mutagenesis associated with MMS exposure was increased up to 30-fold in mip1 mutants containing disease-associated alterations that affect polymerase activity.
Mitochondrial-nuclear crosstalk is critical for the maintenance of cellular homeostasis , and some mitochondrial DNA mutations may perturb crosstalk signaling.
Mitochondrial number , but not size , was increased.
Mitochondrial number is significantly reduced and mitochondrial length is significantly increased.
Mitochondrial oxidative stress and dysfunction have been implicated in the aging process and in numerous chronic diseases.
Mitochondrial physiology was evaluated by high-resolution respirometry and expression of mitochondrial proteins and transcription factors by quantitative PCR and immunoblotting.
Mitochondrial production of superoxide and hydrogen peroxide is potentially important in cell signaling and disease.
Mitochondrial stress is an effective inducer of cellular senescence , but the mechanisms by which mitochondria regulate permanent cell growth arrest are largely unexplored.
Mitochondrial TERT is able to reduce reactive oxygen species , mitochondrial DNA damage and apoptosis.
Mitochondrial topoisomerase I is a genetically distinct mitochondria-dedicated enzyme with a crucial but so far unknown role in the homeostasis of mitochondrial DNA metabolism.
Mitochondrial topoisomerase I was co-immunoprecipitated with mitochondrial RNA polymerase.
Mitochondrial transcription factor A ( TFAM ) plays an important role in the maintenance of mitochondrial DNA integrity.
Mitochondrial turnover involves mitochondrial biogenesis , mitochondrial dynamics , and selective autophagic removal of dysfunctional mitochondria ( i.e. , mitophagy ) .
Mitochondrial turnover is the major contributor to maintenance of mtDNA and functionally active mitochondria.
Mitochondrial ultrastructure abnormality was implicated as a contributing factor in D-gal-induced muscular impairment.
Mitochondria offered an unparalleled source of metabolic energy through oxidative phosphorylation and allowed the development of multicellular life.
Mitochondria organize themselves as dynamic populations within a cell , by undergoing continuous cycles of fission and fusion.
Mitochondria play a central role in bioenergetics and metabolism.
Mitochondria play a key role in common neurodegenerative diseases and contain their own genome : mtDNA.
Mitochondria play a key role in maintaining cellular homeostasis during stress responses , and mitochondrial dysfunction contributes to carcinogenesis , aging , and neurologic disease.
Mitochondria play a key role in the energy supply , cellular redox homeostasis , signaling , and regulation of programmed cell death.
Mitochondria play an essential role in ageing and longevity.
Mitochondria play a pivotal role in cellular bioenergetics and cell-survival.
Mitochondria play important roles in multiple cellular processes including energy metabolism , cell death , and aging.
Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte quality which is important for fertilization and development into viable offspring.
Mitochondria-related oxidative damage is a primary event in aging and age-related neurodegenerative disorders.
Mitochondria-related oxidative stress and mitochondrial DNA mutations are increased during ageing and also by some nucleoside analogue reverse transcriptase inhibitors.
Mitochondria sustain damage with aging , and the resulting mitochondrial dysfunction has been implicated in a number of diseases including Parkinson disease.
Mitochondria-targeted antioxidants have shown great potential because they cross the mitochondrial phospholipid bilayer and eliminate ROS at the heart of the source.
Mitochondria-targeted antioxidants might be used to effectively prevent ROS-induced oxidation of lipids and proteins in the inner mitochondrial membrane in vivo.
Mitochondria to nucleus signaling has been the most extensively studied mode of inter-organelle communication.
Mitochondria were first postulated to contribute to aging more than @number@ years ago.
Mitochondria were suspected to play a vital role in these changes.
Mitophagy , a process whereby damaged mitochondria are selectively removed by autophagy , plays a key homeostatic role in mitochondrial quality control.
Mito-Pim1 increases the proliferation rate by up-regulation of cell cycle modulators Cyclin D , CDK4 , and phospho-Rb.
MitoQ is a ubiquinone derivative targeted to mitochondria which is known to have both antioxidant and anti-apoptotic properties within mammalian cells.
Mitotic check point control by mitotic arrest deficient-like @number@ ( MAD2L1 ) also was perturbed in Lmna ( Dhe / + ) cells.
Mitotic checkpoints sensed the mitotic abnormalities and induced apoptosis.
MitProNet features a user-friendly graphic visualization interface to present functional analysis of linkage networks.
MitProNet is freely accessible at @url@
Mitral annular calcification is a degenerative process.
Mitral annular calcification predicts cardiovascular events , cardiovascular death and overall death.
Mitral regurgitation is a common mitral valve dysfunction which may lead to heart failure.
Mitral regurgitation is one of the most prevalent valvular heart diseases and its prevalence is related to population aging.
Mitral regurgitation is the most common valve abnormality worldwide and its prevalence is expected to increase in the future due to aging of the population.
Mitral regurgitation ( MR ) , currently the most frequent valvular heart disease , is mostly degenerative , linked to aging and of increasing prevalence.
Mitral stenosis , most often caused by rheumatic fever , is uncommon in the United States.
Mitral valve inflow velocities , early deceleration time , and pulmonary vein flow velocities are diastolic parameters that can be measured by phase-contrast CMRI.
Mixed ANOVAs showed that , after training , nursing aides in the intervention group experienced less caregiver distress.
Mixed BM chimeras revealed that the nonhematopoietic environment was a key determinant of NK cell maturation and T-bet and Eomes expression.
Mixed CMBs were the strongest correlate for decline in memory and speed.
Mixed-effect models were used to analyze the demographic risk factors associated with physical function decline.
Mixed effect models were used to examine structural progression between depressed and non-depressed participants with definitive radiographic knee OA.
Mixed-effect regression was conducted.
Mixed effects analyses showed that movement time and tongue strength best differentiated PD from control subjects.
Mixed-effects linear models were used to examine changes in average weekly alcohol intake over time and in relationship to health status.
Mixed effects models also revealed no association with subsequent cognitive declines.
Mixed effects models and log binomial models were used to assess the association of maternal PHIV status with infant outcomes.
Mixed-effects models were fitted with adjustment for demographic and socioeconomic factors , health conditions , and health behaviors.
Mixed-effects models were used to assess effects of pollutants , SNPs , and interactions under recessive inheritance models using repeated measures.
Mixed effects models were used to derive cognitive decline phenotypes from data on repeated cognitive assessments and to perform single nucleotide polymorphism-based heritability estimation.
Mixed-effects regression models were adjusted for demographic , biomedical , and behavioral confounders.
Mixed-effects regression models were used to examine the regression of muscle outcomes on HbA1c.
Mixed-effects regressions were used to examine group differences on continuous T scores and categorical measures of impairment ( T score < 40 ) .
Mixed emotions involve the co-occurrence of positive and negative affect , such that people feel happy and sad at the same time.
Mixed findings have also been published regarding whether somatic cells generated from iPSCs are subject to premature senescence.
Mixed findings have been reported on the relationship between hippocampal integrity and major depression in clinical populations.
Mixed findings were observed between driving performance and cognitive function on self-reported driving habits of participants.
Mixed linear model analyses were performed.
Mixed linear models assessed the ability of standardized baseline CSF biomarker measures to predict rates of whole-brain and regional atrophy over the follow-up period.
Mixed linear models were fit to assess the associations between cortisol diurnal output and physical performance , adjusting for potential confounders.
Mixed linear models were used to estimate the associations between diurnal cortisol and depressive symptoms.
Mixed linear regression models were implemented to assess the associations between smoking indicators and the FI.
Mixed linear regression was used to evaluate mean differences in cognitive decline according to telomere length.
Mixed-methods analysis of this feedback was conducted.
Mixed-model analyses were used to separately examine the effects of practice and age on test performance.
Mixed model analysis was used to calculate each participant's average hearing threshold deterioration rate during the follow-up period.
Mixed model linear regression was performed to assess the association of serum bicarbonate on change in gait speed over time.
Mixed-model repeated measures ANOVAs were performed to estimate the intervention effects.
Mixed models assessed the association of SBP levels with 10-year cognitive trajectories.
Mixed models were used to examine change in CES-D scores according to 25 ( OH ) D categories.
Mixed models with repeated measurements were performed to identify variation in distress and QoL.
Mixed repeated measures analysis was used to compare sleep outcomes at post-treatment and 4-months follow-up , with baseline values as covariates.
Mixed stimuli ( i.e. , a mixture of young and older adult faces ) may impact accurate smile discrimination.
MJD presents strong phenotypic heterogeneity , which has justified the classification of patients into three main clinical types.
MJD's causative mutation consists in an expansion of an unstable CAG tract in exon @number@ of the ATXN3 gene , located at 14q32.1.
MK2 directly phosphorylates RIPK1 at residue S321 , which inhibits its ability to bind FADD / caspase-8 and induce RIPK1-kinase-dependent apoptosis and necroptosis.
M.K. is supported by the AXA Research Fund.
MLBs have been characterized previously as 1-4 μm diameter spherical particles covered by multiple lipid bilayers surrounding a cytoplasmic core of variable density.
ML performance suggests that short-delay consolidation is deficient only in confirmed AD patients.
ML resulted in lower μTBS for both adhesives.
M / L was greater in HT , starting from @number@ to @number@ years range.
MMA-exposed healthcare workers may be at increased risks of untimely deaths from site-specific malignancies.
MMAS included @number@ men ( aged 40-70 years ) and reported a @percent@ incidence of some degree of ED.
MMAS participants were a population-based sample of men living in Boston , Massachusetts , United States.
MM cells and leptin synergistically counteracted anti-tumor functionality of both murine and human iNKT cells.
M-modes were defined as trunk and leg muscles organized into groups with parallel scaling of muscle activation level within a group.
MM of the ubiquitin gene can produce alternative ubiquitin gene products with different and sometimes opposing phenotypic effects.
MMP13 is present in osteoarthritic cartilage and this enzyme plays a significant role in cartilage collagen degradation.
MMP-1 activity in the supernatants and protein levels in the cells were assessed by zymography and western blotting , respectively.
MMP1 mRNA expression increase was observed in fibroblasts cultured in medium collected from UVB-irradiated keratinocytes.
MMP-1 mRNA expression is up-regulated by elevated cysteine-rich @number@ ( CYR61 ) and monocyte chemoattractant protein-1 ( MCP-1 ) via action of transcription factor AP-1.
MMP1 mRNA expression response was assayed in fibroblasts grown in keratinocytes conditioned medium.
MMP-1 secretion was greater for wrinkled-skin fibroblasts , but the extract decreased its secretion for both fi broblasts samples.
MMP-2 and MMP-9 immunostaining also showed an increased reaction in the muscle fiber cytoplasm and endomisium during SAHS progression.
MMP-9 and F2-isioprostane levels did not correlate with WMHv.
MMP-9 colocalized with CAA , correlated with the severity of the vascular pathology , and was detected in proximity to microbleeds.
MM-PBSA calculations revealed that binding was energetically favorable and driven by the electrostatic interactions.
MMP- @date@ be a therapeutic target of the degenerated IVD.
MMPs are a family of proteolytic enzymes and involved in the degradation of the matrix components of the IVD.
MMPs play a critical role in the degradation of collagen in skin , thereby accelerating the aging process of skin.
MMPs serve important functions in the central nervous system ( CNS ) during growth and development.
MMR is widely-used as a diagnostic biomarker for human cancers in the clinic , and as a biomarker of cancer susceptibility in animal model systems.
MMSE correlations suggest a connection with cognitive function in AD.
MMSE improved from @number@ ( @number@ ) to @number@ ( @number@ ) and ADLs similarly improved.
MMSE test-retest reliability was examined among @number@ participants who underwent repeat MMSE testing over an average interval of @number@ days.
MMTMs allow the data to identify canonical pathways and to model the effects of risk factors on an individual's ' closeness ' to these trajectories.
MM was defined as the concurrent presence of > 2 NICM.
MNA correlated with BI ( P < 0.001 ) and albumin ( P < 0.001 ) .
MNA-SF demonstrated high sensitivity but relatively low specificity against the full MNA.
MNA-SF scores and nutritional status according to these three measures were compared.
MNA total and screening scores were positively correlated with albumin , BMI , high-density lipoprotein cholesterol and estimated glomerular filtration rate.
MNC from pioglitazone-treated mice exhibited reduced apoptosis ( AnnexinV-FACS ) .
MNCs were prepared from the buffy-coats of @number@ healthy individual blood donors.
MND size varies with the fiber type and is inversely proportional to the muscle fiber oxidative capacity.
MNK inhibition ablates eIF4E1 phosphorylation and concurrently enhances eIF4E3 expression.
Mn levels were not affected by smoking.
MnSOD and Ub proteins co-localized to CA in both the control and MCI specimens.
MnSOD was lower in patients than in lean controls.
MN to UN latency difference to RF was greater in females than males ( @number@.19±0.15ms vs. @number@.10±0.16ms , p = 0.007 ) .
MN were counted in a total of @number@ binucleated lymphocytes.
MOAG-4 / SERF appears to act independently from HSF-1-induced molecular chaperones , proteasomal degradation , and autophagy.
Mobile health technologies have proved to be a beneficial tool to achieve blood pressure and blood glucose control in patients with diabetes.
Mobility and function are important predictors of survival.
Mobility decreased in the most severe grade ; therefore , the stage of ISLD should be taken into consideration when evaluating spinal stability.
Mobility difficulties were very common : @percent@ of frail individuals had such difficulties versus @percent@ of the non-frail individuals.
Mobility disability and usual gait speed were assessed at baseline and after @number@ ± @number@ years.
Mobility-disability is a common condition in older individuals.
Mobility disability is one of the major risk factors for morbidity and mortality in this age group.
Mobility disability , the main study outcome , is measured as self-reported level of difficulty in walking 2-3 neighborhood blocks.
Mobility disability was also assessed using a performance-based measure.
Mobility disability was defined as a gait speed less than or equal to @number@ m / s based on annual assessment of timed walk.
Mobility disability was operationalized as gait speed of < 0.8 m / s while completing a 20-foot walk ( @number@ m ) .
Mobility impairment contributes to the construct of frailty and channels adverse events.
Mobility impairments were based on annual timed walking performance.
Mobility is critical in maintaining independence in older adults.
Mobility limitation was assessed semi-annually and defined as reporting any difficulty walking one-quarter of a mile or climbing @number@ steps on @number@ consecutive 6-month contacts.
Mobility limitation was defined as @number@ consecutive reports of difficulty walking one-quarter mile or climbing @number@ steps during semiannual assessments over @number@ y.
Mobility-related factors varied across trajectories with the most unfavorable values in poor mobility trajectories and the most favorable in high mobility trajectories.
Mobility was assessed by the 6-minute walk test.
Mobility was assessed by the Timed Up and Go Test ( TUGT ) .
Mobility was assessed via gait speed , timed up-and-go , chair stand , and as a composite physical performance score ( PPS ) .
Mobility was assessed with the Timed-Up-and-Go ( TUG ) .
MOBP RA + patients have more severe white matter degeneration in bvFTD that may contribute to shorter disease duration.
MoCA was more sensitive in detecting MCI than MMSE and its inner consistency was also slightly higher.
MOD cavities were prepared with approximal finishing lines in dentin and enamel.
Mode ages at each wave were @number@ @number@ @number@ and @number@ y ( ages ranged from 8-18 y ) .
Mode effects also became stronger over time for reports of negative affect.
Model A is a multiple regression model with cognitive and symptom variables as predictors and functional capacity as the latent outcome variable.
Model-based analysis demonstrates a unique performance signature profile associated with normal aging.
Model calculations further indicate that no such sex paradoxon occurs , and a much clearer risk stratification can be achieved with fecal immunochemical tests.
Model calculations of excess relative lung cancer death risk agree well with those from the descriptive , BEIR VI-type model for WISMUT miners.
Model calculations suggest that men with negative gFOBT likewise have substantially higher prevalences of colorectal neoplasms than gFOBT positive women in each age group.
Model cases illustrated real-life examples of the NPFL role.
Model covariates included race , respondents ' education , and income status during childhood and adulthood.
Model-estimated item thresholds were widely distributed across the range of physical functioning.
Model fit was determined using the c-statistic and evaluated vis-a-vis our replication of a published model.
Modelflow aortic ages were comparable with chronological ages in both sedentary groups , indicating that healthy sedentary individuals have age-appropriate aortas.
Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans.
Modeling and simulation ( M & S ) is proposed as a basis for assessing the impact of age-related changes and their clinical implications.
Modeling cognitive change in an epidemiologic sample may serve as a useful benchmark for evaluating cognitive change in future intervention studies.
Modeling complex brain disorders should not be based on a single model or species.
Modeling DS is beginning to yield pharmaceutical therapeutic interventions for amelioration of intellectual disability , which are currently being tested in clinical trials.
Modeling employed gender , age , perceived income adequacy , and education as potential confounders.
Modeling employs the theory of planned behavior , and also finds injunctive social norm has predictive primacy over attitude and perceived behavioral control.
Modeling general proteostasis provides a rational basis for tackling some of the most challenging diseases facing mankind in the 21st century.
Modeling projects MoCA scores from CCFM scores using the equation : MoCA = ( @number@ × CCFM ) + @number@
Modeling the number of people visually impaired as a result of this disease will help establish the projected morbidity and resource burden.
Modeling tools were applied to define the existing workflow.
Model inversion and posterior distributions are obtained using earlier established variational methods enabling Bayesian evidence-based comparisons between various models of structural change.
Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established.
Modelling is key in understanding how these architectural modifications affect blood flow and mass transfers in such complex networks.
Modelling the human brain as a complex network has provided a powerful mathematical framework to characterize the structural and functional architectures of the brain.
Model @number@ examined demographic factors , and model @number@ examined the contribution of the remaining variables on cognitive performance.
Model @number@ including socio-demographics and health characteristics explained @percent@ of depressive symptoms.
Model @number@ ( n = @number@ ) assessed chemotherapy in ER + patients.
Model @number@ pertained to Stage @number@ whereas Model @number@ used data from the Final Stage.
Model organism data , next-generation sequencing , and further advances call for sophisticated large-scale data analysis.
Model organisms , including invertebrates , have been extensively utilized to gain insight into the molecular and cellular mechanisms underlying disease.
Model parameters , generated from Swedish mortality data ( 1751-2010 ) , exhibit biologically meaningful correspondences to economic , health and cause-of-death patterns.
Model parameters yield intrinsic and extrinsic cumulative survival curves from which we derive intrinsic and extrinsic expected life spans ( ELS ) .
Model performance was similar in the derivation and validation cohorts ( C-statistics = @number@ and @number@ respectively ) .
Models adjusted for age , sex , race / ethnicity , education , and obesity.
Models differentiated three forms of selection bias : indirect and direct selection as well as reverse causation.
Model selection algorithms and statistical analyses , respectively , were used to examine the patterns and significance of the changes.
Models for safe and effective approaches to treating pain in older adults exist , but treatments must still be tailored for each individual's needs.
Model simulations predicted that MCAD deficiency would have no effect on the pathway flux at low concentrations of the mFAO substrate palmitoyl-CoA.
Model simulations predicted that phospholamban phosphorylation is a potent target of the increase in PKA activity that links to increase in spontaneous AP firing rate.
Models ( @number@ ) and ( @number@ ) had commensurate reductions in animal-based protein intake.
Models of care are evolving that aim to deliver multidimensional assessment and management by multidisciplinary specialist care teams ( comprehensive geriatric assessment ) .
Models of care involving geriatricians vary across healthcare settings , and it is unclear which CGA model is most effective.
Models of duration bisection have focused on the effects of stimulus spacing and stimulus modality.
Models of the temporal evolution of AD biomarkers can take the form of plots of biomarker severity ( degree of abnormality ) versus time.
Models that included Wrist correctly classified time spent at light PA better than other models.
Models were adjusted for age , BMO area , and axial length in the regression analysis.
Models were adjusted for age , education , and race and ethnicity.
Models were adjusted for age , education , concurrent diet and other known risk factors.
Models were adjusted for age , education , disease duration , language , and levodopa equivalent daily dose.
Models were adjusted for age , sex , principal components to account for ancestry , and additional health indicators.
Models were adjusted for age , sex , race , educational attainment , and other health and lifestyle covariates.
Models were adjusted for a range of demographic , physical health and mental health measures.
Models were adjusted for body composition ( fat mass , fat free mass ) , smoking , disease count and physical activity.
Models were adjusted for clinical characteristics.
Models were adjusted for health , employment and wealth.
Models were adjusted for sex and education , with age as the time variable.
Models were adjusted for sex , education , and medical comorbidity.
Models were adjusted for sex , smoking , body mass index , alcohol intake , psychological distress and financial difficulties.
Models were also fit to compare factors associated with objective failure and subjective failure only.
Models were assessed unstratified and stratified according to race because allele distributions were different between white and black participants.
Models were constructed adding race , depression , abuse , smoking , substance use , transactional sex , and comorbidities to determine whether predictability improved.
Models were developed using Cox regression and evaluated using c statistics.
Models were estimated using national survey data.
Models were evaluated by Spearman Rs coefficient and ROC area.
Models were fitted with multiple imputation data using the STATA mi module.
Models were repeated in the subsample with neuroimaging , before and after adjustment for regional gray matter volume.
Models were run without adjustment , adjusted for basic demographic and clinical factors , and adjusted for vascular risk factors.
Models were stratified by sex and adjusted for differences in human capital.
Models were weighted to account for selective attrition.
Model validation required that the disease-specific transition parameters be identical for both Predictors Study cohorts.
Moderate adherence to the MIND diet may also decrease AD risk.
Moderate agreement was observed both between and within observers when applying the ACR criteria for hand osteoarthritis.
Moderate alcohol consumption is unlikely to increase the risk of AMD.
Moderate amounts of alcohol ( 25-30g / day ) increase CRC risk.
Moderate and severe ED is correlated with depression , whereas LUTS are not related to depression in Japanese LOH patients.
Moderate and severe obesity were significantly associated with chiropody service use ( P < @number@ ) with an estimated annual cost of €919 , 662.
Moderate correlations between semantic clustering Category Fluency Test ( r = @number@ ) were also found.
Moderated mediation analyses were subsequently conducted with age , sex , and BMI.
Moderate elevations of testosterone appear to stimulate LH production at both the hypothalamic and pituitary level , while very high levels of testosterone suppress LH.
Moderate evidence for activity level ( AL ) predicting FOF was identified , however the evidence of this predicting FSe and BC was tentative.
Moderate evidence was found for anxiety predicting FSe.
Moderate evidence was found for depression predicting both FOF and BC.
Moderate evidence was found for QoL predicting both FSe and BC.
Moderate exercise did not enhance the effects of GH manipulation.
Moderate exercise is an effective and economic way to prevent and treat cardiovascular diseases.
Moderate intensity VO ( 2p ) and ∆ [ HHb ] kinetics were examined in @number@ young males ( @number@ ± @number@ years ) .
Moderately elevated levels of inflammatory stimuli supported osteoblastogenesis whereas the same treatment reduced adipogenic differentiation in MSCs from young and intermediately aged donors.
Moderate mechanical loading causes hypertrophy and reduced mechanical loading causes atrophy.
Moderate methodological quality emerged.
Moderate overprediction of mortality in this young , healthy population suggests minor recalibration that could improve fit among similar patients.
Moderate pain and transient erythema were observed as the two main discomforts associated with the treatment.
Moderate PA without WL had no effect on body composition.
Moderate ( physiological ) exercise is characterized by a range of equilibrium between matrix anabolic and catabolic processes , or anabolism beyond catabolism.
Moderate predictors were age and gender.
Moderate sport harvests are unlikely to affect the evolution of phenotypic traits and reproductive strategies in female chamois.
Moderate-to-excellent concurrent validity was seen for the Stillness test.
Moderate-to-severe periodontal disease was defined as cumulative numbers of teeth exhibiting PD ≥4 mm or ABL ≥40%.
Moderate to severe psoriasis is associated with concomitant diseases that may have a significant impact on patients.
Moderating effects of cardiometabolic conditions , physical functional limitations , and WM hyperintensities were not significant.
Moderating effects of physical function and chronic diseases were tested using hierarchical regression models.
Moderating effects were examined according to two- and three-way interaction terms in the regressions.
Moderation analysis was performed to verify the effect of gender on the body fat-cognition relationship.
Moderation by gender and age was examined.
Moderation of the physiological processes , which enhance disability in aging , turns out to be a major concern in health research and clinical practice.
Moderation tests reveal that age is associated with a greater increase in stigma in the context of greater functional limitation and increases in limitation.
Moderator analyses detected that the type of network assessment affected the reported size of global , personal , and family networks.
Moderator analysis of this dataset also found significant moderator effects of gender on multiple measures of exercise.
Moderator and dosage analyses of the dataset found no significant program effects.
Moderators of SOPT were also examined.
Moderators that may interact with depression to yield such effects in delimited samples remain to be identified.
Modern aesthetic surgery of the face began in the first part of the 20th century in the United States and Europe.
Modern antiretroviral treatment belongs to the greatest success of current medicine.
Modern day patients with chronic inflammatory disease such as rheumatoid arthritis , systemic lupus erythematosus , and human immunodeficiency virus experience premature atherosclerosis.
Modern developments in population dynamics emphasize the role of the turnover of individuals.
Modern experimental data about its osteogenic activity allow melatonin to be considered as potential drug for treating bone diseases.
Modern eye protection , used daily , offers the opportunity to prevent these adverse sequelae of lifelong UV exposure.
Modern imaging equipment can facilitate precise measurement and monitoring of vascular features.
Modern laboratories generally report a calculated hematocrit value , and using hemoglobin for most classification purposes is preferred.
Modern nosology differentiates primary from secondary photodermatoses.
Modern rehabilitation medicine is propelled by newfound knowledge aimed at offering solutions for an increasingly aging population afflicted by chronic debilitating conditions.
Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception.
Modern society is witnessing a widespread tendency to postpone parenthood due to a number of socioeconomic factors.
Modern techniques using Fourier spectral analysis of the reflected light enhance axial resolution to 5-10 μm , almost matching classic histological sections.
Modern technologies have improved our ability to determine accurate IOP after refractive surgery despite postoperative changes in corneal architecture.
Modern technology which can allow \ "real time \ " assessment may be a solution.
Modern terminology on active and healthy aging used in scientific and project activities is discussed.
Modern way of human life is pushing our physiology at its limits.
Modes of failure were determined.
Modest improvement was achieved in maternal dietary practices during lactation and feeding of the sick child after illness.
Modest personal care should not come at the price of surrendering one's autonomy.
Modest Se deficiency is common in many parts of the world ; optimal intake could prevent future disease.
Modic changes are of increasing interest , however their age and gender prevalence are not well described.
Modifiability , relationship strength , and population-level effect of the determinants were rated to identify areas of priority for research and interventions.
Modifiable neighborhood characteristics of older people dwelling in low-income communities are under-studied.
Modification of autophagy flux is involved in developmental processes , resistance to stress conditions , aging , cell death and multiple pathologies.
Modification of these risk factors could have the potential to prevent new-onset CMBs , particularly those occurring in a lobar location.
Modification of these risk factors is expected to have a large impact on preservation of functional independence through prevention of overt and covert vascular disease.
Modifications in mutable domains associated with service utilization such as perceived discrimination , social support , and having private insurance may be beneficial.
Modifications of the extinction programme show promise but need further evaluation.
Modifications to CHD classification within UNOS would help better understand CHD CHLT and OHT outcomes.
Modifications to crystallins and the lens intermediate filaments have been implicated in this phenomenon.
Modifications to daily PA may attenuate cognitive decline , and prospective studies are needed to test this possibility.
Modifications to the gene panel permit accurate detection of structural variation in APP.
Modification was assessed as changing from one APD to another and / or adding a new APD to an existing regimen.
Modified Cobb angle of kyphosis , calculated from T4 through T12 , was assessed from supine lateral spine radiographs.
Modified Kupperman index were used to evaluate climacteric symptoms during the recent week and awareness of hormonal replacement therapy were studied.
Modified radical mastectomy and adjuvant chemotherapy were more commonly performed in group @number@ ( p = 0.001 and p = 0.001 , respectively ) .
Modified treatment approaches can allow physicians to safely treat patients with skin of color with energy devices.
Modifiers of neurocognition in HIV-infected women included detectable HIV plasma viral load , active hepatitis C virus co-infection , and self-reported depression symptoms.
Modular organization and small-world attributes are evident at birth with several important topological metrics increasing monotonically during development.
Modulating neuronal activity may therefore be a viable therapeutic strategy in AD that can complement existing anti-amyloid strategies.
Modulating p53 interactions within the tetramer could therefore present a novel promising strategy to fine-tune p53-based cell fate decisions.
Modulating the mode of hTERT pre-mRNA splicing is providing a new precept of therapy for cancer and aging-related diseases.
Modulation from the dopamine system is thought to be critical for the gating of information during working memory.
Modulation in kinetic parameters of CAT , CYP-450 and iNOS enzymes in response to ELF-EMF indicates an interaction between the ELF-EMF and the enzymological system.
Modulation in the efficacy of homonymous Ia afferents to discharge spinal motor neurones was assessed by means of the Hoffmann ( H ) reflex method.
Modulation of DNA repair proteins by small molecules has attracted great interest.
Modulation of insulin signaling , protein aggregation , stress , free radical damage and inflammation are the major causes for deleterious changes resulting in aging.
Modulation of MiRNAs , regulated by exercise in human skeletal muscle , depends on type , duration and intensity of an exercise performed.
Modulation of molecules downstream such as DDAH I can be used to regulate ADMA levels.
Modulation of SHP-1 activity could be a target to restore altered T cell functions in aging.
Modulation of the endogenous cannabinoid system is emerging as a potentially viable option in the treatment of neurodegeneration.
Modulation of the mu-alpha and mu-beta spontaneous rhythms reflects plastic neural changes within the primary sensorimotor cortex ( SM1 ) .
Modulation profiles were used within a non-linear SVM framework to classify individuals as young or older.
Modulations of angiogenesis may influence cancer rates.
Modulators of purine actions have the potential to alleviate insomnia and other sleep disorders based on their physiopathological role during the sleep process.
Modulatory effects of behavioral factors highlight their value as possible prevention targets.
Mohs ' chemosurgery for palliative purposes is not a radical treatment , but contributes to the patient's quality of life.
Mohs ' chemosurgery may become one of the treatment options for such patients.
Mohs micrographic surgery has become the treatment of choice in many cases but is not always necessary or feasible.
Moisture content in the over 40-year-old group , in particular , was lower than in the 20- to -30-year-old group.
Moisture content of facial skin increased up to @number@ and @percent@ from initial levels in the YS and MN groups , respectively.
Moisturizing of the skin is recognized as the first anti-aging skin care.
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Molecular age biomarkers provide a potential solution to this problem.
Molecular alterations due to chronic exposure to cigarette smoke remain unclear.
Molecular Carcinogenesis published by Wiley Periodicals , Inc.
Molecular changes involved in innate immunity signaling , tumorigenesis , and inflammation were studied.
Molecular characterization indicates that the mutant phenotype is caused by over-expression of the At2g26130 gene encoding a RING-type zinc finger putative ubiquitin ligase.
Molecular cross-talk between neuronal drebrin A and cofilin is believed to be a part of the activity-dependent cytoskeleton-modulating pathway in dendritic spines.
Molecular damage of cellular compartments is mainly caused by reactive oxygen species ( ROS ) .
Molecular data showed that effects of ELF-EMF might be mediated via Akt and ERK signal pathway , as demonstrated using their specific inhibitors.
Molecular docking studies of the oak phenolics with known resveratrol protein targets also show that these compounds dock favorably to the protein targets.
Molecular dynamic simulation studies predict that p.Arg217Cys and p.Arg217His narrow the substrate cavity of the protein and disrupt transporter dynamics.
Molecular evidence derived from genetic techniques indicates atherosclerotic lesions may begin to form as arterial repair fails , rather than merely following arterial injury.
Molecular genetic research has provided some evidence for the association between depression and metabolic disorders.
Molecular genetic studies of AUD may therefore benefit from stratifying by age.
Molecular genetic studies should now identify genes related to insomnia progression during childhood and adolescence.
Molecular hydrogen ( H2 ) was believed to be inert and nonfunctional in mammalian cells.
Molecularly , Wt1 represses expression of Prss29.
Molecular mechanisms behind protein aggregations are weakly understood.
Molecular mechanisms leading to pressure ulcer development are scarce in spite of high mortality of patients.
Molecular mechanisms of Cytoflavin action , including regulation of the activity of cell signaling pathways through intermolecular interactions were found.
Molecular mechanisms of hypoglycemia remain unclear , but are associated with premature onset of age-related-diseases.
Molecular mechanisms that protect CNS neurons against ligands ( ADDL ) , responsible for synaptic deterioration underlying AD memory failure , have been identified.
Molecular mechanism studies confirmed that Bmi-1 mediated these effects of miR-495 on MSCs.
Molecular mechanisms underlying neurodegenerative diseases converge at the interface of pathways impacting cellular stress , protein homeostasis and aging.
Molecular mechanisms underlying T-cell aging are beginning to be understood.
Molecular Misreading ( MM ) is the inaccurate conversion of genomic information into aberrant proteins.
Molecular modeling and docking showed that emoghrelin as well as GHRP-6 could fit in and adequately interact with the binding pocket of the ghrelin receptor.
Molecular modeling studies were performed to acquire data about the binding modes of the inhibitors.
Molecular modelling studies were performed against human MAO-A and MAO-B for the explanation of binding site interactions.
Molecular models of OC90 exhibit a surface of uniform negative electrostatic potential , enabling localized supersaturation.
Molecular probes have been used to study neurovascular leak , but this approach does not adequately estimate vascular permeability of nanoparticles.
Molecular profiling identified @number@ genes differentially-regulated in PSEN1 NPCs relative to control NPCs.
Molecular regulation of reparative / homeostatic autophagy induced by failure of vital resources and by cellular stress is considered.
Molecular structures responsible for Ca ( v ) β oligomerization reside in @number@ regions of the guanylate kinase subdomain of MAGUK.
Molecular studies in model organisms have identified potent longevity genes which can delay the aging process and extend the lifespan.
Molecular studies of alterations of single genes have provided evidence that intestinal and diffuse type GC evolve via different genetic pathways.
Molecular subtypes of AML were found to exhibit highly distinct DNA methylation profiles.
Molecular targeted treatment is the further of cancer treatment.
Molecular targets in this pathway may lead to novel therapies to limit arterial stiffening and the progression of disease in arteries exposed to d-flow.
Molecular targets , signaling pathways , and networks common to adaptogens have been identified.
Molecular technologies and machine-learning methods have already yielded diagnostics that help guide cancer treatment and cardiovascular procedures.
Molecular tumor signatures may help better select patients for treatment in the future.
Molecular virology methods including polymerase chain reaction , cloning and sequencing have revolutionised our understanding of viral genome variation.
Monaural , 2-channel AMLRs were acquired from Fz and Cz electrodes with @number@ stimuli ( clicks , @number@ Hz , and @number@ Hz ) .
Monetary incentives were also manipulated.
Monetary incentives were manipulated such that recall led to gains or forgetting led to losses.
Monitoring anticoagulant activity may help improve the safety profile of anticoagulants in elderly patients with renal impairment , particularly when approved dose reductions are unavailable.
Monitoring DA and DOPAC in CSF of l-DOPA-treated PD patients may help identify patients at risk of developing LID.
Monitoring for nutritional deficiencies , including Zn , is essential for optimal patient outcomes.
Monitoring for nutritional deficiencies , including Zn , is essential for optimal patient outcomes.
Monitoring hcy levels and the use of vitamin supplementation to treat hhcy may therefore prove advantageous for the prevention and management of cognitive impairment.
Monitoring of asymptomatic patients is important because early intervention , when valve function worsens or symptoms develop , is associated with better outcomes.
Monitoring of brain responses in these regions offers an obvious way to test the effect of drugs.
Monitoring of CAP may help to screen the high-risk patients in the elderly population.
Monitoring of oxidative modification or oxidative damages of biomolecules may therefore be essential for the understanding of aging , and age-related diseases.
Monitoring rules should be sensitive to targeting aging-related , rather than disease-specific , outcomes.
Monitoring subcortical structures in combination with the EEG might in the future allow a better evaluation and a more precise adaptation of balanced anesthesia.
Monitoring the element concentrations in the human body is of critical importance for health and longevity.
Monitoring these processes is critical to realistically predict the effects of interventions on infectious diseases dynamics.
Monoacylglycerol lipase ( MAGL ) represents a primary degradation enzyme of the endogenous cannabinoid ( eCB ) , 2-arachidonoyglycerol ( 2-AG ) .
Monoamine oxidase B ( MAO-B ) has been implicated in the pathogenesis of Alzheimer's disease ( AD ) and other neurodegenerative disorders.
Monoamine oxidase ( MAO ) activity and lipofuscin level in brains of aging mice were also characterized.
Monoaminergic-related polymorphisms may influence medication response and susceptibility to side effects in elderly individuals.
Monoamines , steroid hormones ( glucocorticoids and mineralocorticoids ) , endocannabinoids , and proteins all influence body weight.
Mono- and polysensitization were defined by a positive skin prick test to one or more than one allergen respectively.
Monochromatic aberrations of left eyes were measured using iTrace Dynamic Laser Refraction at @number@.0-mm pupil size without cycloplegia.
Monoclonal B cell lymphocytosis ( MBL ) is now recognized as the B-lymphocyte analogue of a monoclonal gammopathy of unknown significance.
Monoclonal gammopathy of undetermined significance ( MGUS ) is a common condition in the elderly.
Monocular fields were combined into a binocular field based on the more sensitive point from each eye.
Monocyte depletion prevented HUCB cell treatment from reducing infarct size while monocyte enrichment was sufficient to reduce infarct size.
Monocyte-derived antigen-presenting cells of both short and long telomere groups induced similar expansions of influenza M1-specific CD8 ( + ) T cells.
Monocyte HLA-DR expression , regulatory T cells , plasma interleukin ( IL ) -6 , and IL-8 levels were also measured.
Monocyte / macrophages were identified as CD14 + mononuclear cells and divided into subpopulations based on the co-expression of CD16.
Monocytes are mediators of the inflammatory response and include three subsets : classical , intermediate , and nonclassical.
Monocytes play a vital role in HIV-associated neurocognitive disorder ( HAND ) , postulated to transport HIV into the brain and secrete pro-inflammatory cytokines.
Monolayer barrier properties were assessed by transepithelial resistance measurements.
Monolithic zirconia single crowns were cemented and artificially aged.
Monomeric Aβ40 and Aβ42 are the predominant forms required for synaptic plasticity and neuronal survival.
Monomeric Aβ attenuated the effect of soluble oligomers.
Monomeric form of Aβ , indeed , could exert a physiological role.
Monophasic monodensified gels show large pools of hyaluronans throughout all the thickness of the reticular dermis.
Monopolar radiofrequency ( RF ) is emerging as a gentler , nonablative skin-tightening device that delivers uniform heat to the dermis at a controlled depth.
Monte Carlo simulation was implemented to correct for multiple comparisons ( threshold of @number@ contiguous voxels with a z-value ≥ @number@ ) .
Monthly 1-hour discussion sessions utilize a Social Cognitive framework and focus on knowledge , social support , and self-efficacy to increase lifestyle PA.
Monthly falls diaries recorded falls.
Monthly falls reports were collected over @number@ months.
Monthly minodronate is a promising new BP and potential first-line drug for the treatment of osteoporosis in postmenopausal women.
Monthly three-dimensional ( 3-D ) volumetric assessments were performed for @number@ months after treatment.
Month @number@ when nearly all participants were discharged from the index hospitalization , was used as a reference.
Montmorillonite is a common medicine used to treat diarrhea.
Mood , as assessed by the Profile of Mood States , and salivary α-amylase activity were examined before and after walking.
Mood / cognition , attention / memory and gastrointestinal domains are the most frequent in PD patients and rarely seen in controls.
Mood disorders and sleep disturbances are closely related.
Mood disorder , urinary incontinence , and region were significantly associated with use of these drugs.
Mood , functional capacity , and general balance and mobility were additional secondary outcome measures.
Mood was measured by the Montgomery-Åsberg Depression Scale and activity level by @number@ survey items.
Moral reasoning was found to be guided by ideologies related to the historical and cultural context of the Swedish welfare state.
Moray House Test scores showed strong concurrent and predictive validity with \ "gold standard \ " cognitive tests at ages @number@ and @number@
Morbidity accounts of depressive symptoms and suicidal thoughts were examined for a subsample that also underwent complete medical examination ( n = @number@ ) .
Morbidity and mortality associated with viral infections increase with age , although the underlying mechanisms are unclear.
Morbidity and mortality data are important for planning and implementing healthcare strategies of a country.
Morbidity and mortality from malignant neoplasms increases each year , and the average age of patients with first diagnosed decreases.
Morbidity and mortality rates reported for neurosurgical procedures in the elderly vary widely.
Morbidity burden was established through rates of visual impairment.
Morbidity can be caused by organ damage from granulomatous inflammation , treatment complications and psychosocial effects of the disease.
Morbidity data were also obtained from the Korean Community Health Survey @number@
Morbidity of sarcoidosis is reflected by a trend of increased hospitalizations over recent years and increased use of healthcare resources.
Morbidity was defined as grade @number@ to @number@ chronic conditions ( Common Terminology Criteria for Adverse Events version @number@ ) .
Morbidity was higher in the ID group and showed a higher prevalence of neurological and mental health disorders.
Morbid obesity was associated with dietetic service use ( P < @number@ ) with an annual cost of €580 , 013.
More accumulation of clinical data is needed to evaluate the significance of local resection of malignant PNETs in pancreatic head and cytoreductive surgery.
More accurate understanding of the molecular mechanisms of geriatric NAFLD will help in identifying the most appropriate diagnostic and therapeutic approach for individual elderly patients.
More advanced staging and late presentation were important predictors of colorectal cancer survival.
More AEs for the Zagreb regimen were observed within the first @number@ hours , especially for male and people < @number@ y.
More affordable direct-to-consumer hearing technologies are increasingly gaining recognition , but the performance of these devices has been poorly studied.
More asymmetric N170 responses predicted greater allocation of late selection resources to target letters in the ignore color , as indexed by P3b amplitude.
More attention should be paid to DSI even when each of vision and hearing function is only minimally impaired.
More attention should be paid to occult renal tubular damage in order to prevent end-stage renal disease.
More attention should be paid to the presence of precursor symptoms , indicating a developing psychiatric episode.
More attention to patients from nursing homes is needed in the health care system.
More baseline depressive symptoms and worsening of these symptoms were also associated with accelerated HcV loss in women.
More broadly , our dual experimental approach offers new opportunities for studying the evolutionary potential of transmission traits in other vector / pathogen systems.
More broadly , these findings also suggest that properties of brain networks may capture individual differences in learning and neuroplasticity.
More broadly , this approach provides a quantitative foundation of AM and PM occurrence , a crucial yet largely unexplored dimension of recollection.
More broadly , this regulation of pluripotency networks and Sox2 in particular is critical for the initiation of tumors upon loss of Rb in mice.
More careful consideration of the life-history context and bioenergetic variables will improve our understanding of the mechanisms that underlie the life-history patterns of animals.
More cautious selection of medications in older adults may reduce these potential risks.
More chronic inflammation was associated with more BPH.
More clarity on this issue is needed.
More clinical studies are needed to better understand the role of prebiotics in the management of MetS components.
More comorbidities were associated with PIM initiation , especially in the non-AD group.
More complex is the demonstration of effects on female reproduction and on pregnancy.
More complex neuropsychological performance was impaired in tasks requiring visual memory and sequential processing , which was correlated with inhibitory control and antisaccade accuracy.
More data are needed to determine the long-term effect of hormonal agents from tamoxifen to GnRH agonists on ORT.
More data is needed to keep pace with clinical demand.
More data is needed to strengthen the evidence base.
More depressed seniors reported less fear of falling after TC.
More depressive symptoms predicted subsequently stronger declines in perceptual speed over time lags of @number@ year.
More detailed examination of mean leukocyte telomere length by age shows that the regional telomere length difference declines at older ages.
More detailed information could be gained through the development of our network assessment instruments for older people.
More detailed phenotyping , especially of AMD , is required as it appears to be not one disease , but a group of diseases.
More drinks / week were associated with higher education and lower anxiety ( SIGH-A ) .
More effective and personalized treatment for diabetes should be considered in this particularly high-risk patient population.
More efforts are needed in clinical settings to train health care practitioners to identify depressed elders with visual impairment and provide appropriate treatment.
More effort should be made to decrease prolonged benzodiazepine use in this middle-aged group , because of the increasing risks with ageing.
More efforts to understand what is reasonable prescribing at these older ages are needed.
More emphasis is needed in graduate nursing curriculums and in precepted clinical experiences regarding UI in women.
More emphasis may thus need to be placed on the oral health of the aging population in Ghana to avoid it.
More environmental family / social support was associated with lower RRR of high frequency of self-perceived uselessness.
More evidence is needed to support certain fat-related indicators in fracture risk prediction , but regional adiposity measures appear promising.
More evidence is needed to validate the modified PF model and support its application in geriatric practice.
More experimental and clinical studies are required to clarify the role of sclerostin in CKD.
More extensive research is needed to precisely identify the effect of service dogs on the long-term management of MWC use.
More females met the relative PA recommendation compared to males.
More flexible and useful models require a systems-biology approach to gathering and analysis of data.
More frequent SCr measurements may be helpful for the early diagnosis of transient geriatric AKI.
More fundamental and prospective research is necessary to clarify their clinical value.
More generally , data integration from multiple unbiased screens can provide insight into human disease mechanisms.
More generally , our results provide insights that are applicable to the implementation of other dense reference panels that are under development.
More generally , they emphasize the importance of sex-sensitive evaluations of cognitive training effects.
More generally , we find that people contrast current experiences with their younger and older selves.
More had been in opposite-sex marriage than in same-sex marriage.
More highly educated and younger participants exhibited better performance on cognitive tests.
More highly educated women were more likely to have controlled hypertension than non-educated women ( OR , @number@ p = 0.013 ) .
More imageable words induced more semantic involvement in reading , yielding an AoA effect in Spanish.
More important , A-582941 completely restored cognition in aged 3xTg-AD mice to the level of that in age-matched nontransgenic mice.
More important , conditional knock-out of the
More important , direct knockdown of GMPS by RNA interference resulted in reduced cell viability and was sufficient to trigger cellular senescence.
More importantly , a pharmacological inhibition of CN by cyclosporine A ( CsA ) ameliorated the α-syn-induced loss of mDA neurons.
More importantly , clear differences emerged from the comparison between the two amnestic MCI subtypes.
More importantly , clinical trials approved by the US government have shown promising prospects in RPE transplantation.
More importantly our data indicate that eIF2α phosphorylation acts in a cytoprotective manner , whereas the eIF2α kinases PKR and GCN2 promote vorinostat-induced apoptosis.
More importantly , pancreatic hyperechogenicity may not be a certain indicator of pancreatic fat infiltration.
More importantly , reduction in p21 expression in MSCs enhanced the bone repair capacity of MSCs in a rodent calvarial defect model.
More importantly , the increased computation time ( ≤10% ) was minor as compared to the acceleration provided by the proposed method.
More importantly , the insights and significance of the encapsulated cells are also discussed in the application of treating various diseases.
More importantly , the predictive power of this model was similar in different age-groups.
More importantly , the time needed for focus switching was longer in children than in adolescents and younger adults.
More importantly , transmissibility to the head is not different between groups.
More importantly , we demonstrate an age-dependent down-regulation of NapoE gene , rendering it a suitable biomarker of aging.
More importantly , we demonstrated that PIM-1 is also a direct target of IL-6 / STAT3 signaling and mediates cytokine-induced cellular senescence.
More importantly , we found high correlations between younger and older adults , showing that our data are generalizable across different ages.
More importantly , we found that lower activation in changed frontal and parietal regions was associated with worse cognitive function in high loads.
More importantly , when CG was measured on Prolonged Grief Disorder Scale , nearly half of CGGT participants realized clinically significant improvement.
More important , there was no evidence for a significant decrease in object-location binding with increasing age.
More important , this impact was specific to subjective perceptions of cognitive costs.
More individuals are living longer and aging with the health-related consequences associated with HIV and multi-morbidity.
More information is required on how treatments impact physical function.
More intense physical activity may occur in recreational settings than neighborhood streets.
More intensified HF medication at month @number@ was associated with better long-term HF hospitalization-free and overall survival.
More intensive fitness programs may be particularly important for people with both DS and stroke.
More intensive rather than currently recommended levels of control associated with higher verbal fluency performance regardless of adjustments ( P < @number@ ) .
More intensive renewal requirements and being the subject of a medical report to the licensing authority was associated with delicensure.
More investigations in large well-designed studies are needed to confirm these findings and to clarify the underlying mechanisms of gender differences in lung cancer risk.
More investigations on the unique biologic and clinical characteristics of tumors in this population are needed.
More knowledge on the association between retirement and age related cognitive decline as well as knowledge on the mechanisms behind these associations is needed.
More knowledge will contribute to the simple prevention of this type of ADR.
More laterally , the orbicularis retaining ligament was released , connecting the dissection with the prezygomatic space.
More longitudinal data are needed.
More longitudinal studies are needed , and novel strategies of genomics and epigenetics can further exploit this powerful method to inform the field.
More longitudinal studies are needed to determine the success of the DEU model as a long-term solution to this clinical problem.
More long-term studies are needed to evaluate the multitude of factors that may disrupt hypothalamic , pituitary , and ovarian function in women with diabetes.
More men than women ( P < @number@ ) deteriorated into frailty.
More MHV participants discussed pain and disability as barriers to bone health behaviors and fear of deteriorating health as motivators.
More new cancer cases and deaths occur in developed countries compared with developing countries.
More offspring of long-lived parents had lower calcium scores than controls.
More older patients had history of stroke and / or suffered from diabetes.
Moreover , [ 18F ] -FDG uptake did not correlate to measures of ex vivo amyloid burden.
Moreover , A1-carriers exhibited less blood oxygen level-dependent ( BOLD ) activation in left caudate nucleus , a region critical to updating.
Moreover , abnormalities of supraspinatus , patellar and Achilles tendons were evaluated with a standardized ultrasound ( US ) procedure.
Moreover , a brief caregiver interview provides an assessment of behaviour changes and psychotic symptoms usually associated with ALS patients.
Moreover , abuse and caregiving status were associated significantly and independently with higher levels of depressive symptoms.
Moreover , a c.1166-14 1166-11delTACT mutation in the intron @number@ was found in a living male patient with limb onset at age of @number@
Moreover , accumulating data have been demonstrating astrocytes being the essential cell type in maintaining proper central nervous system functioning.
Moreover , a consensus for defining sarcopenia continues to elude us.
Moreover , acrosomal development of spermatids was clearly revealed.
Moreover , active involvement of KUs throughout the review process will ensure the results are relevant to different levels of decision-making.
Moreover , activity in dACC during episodic AM retrieval was correlated with inhibition and richness of memories in both groups.
Moreover , acto-myosin contractility regulates ICAM-1 expression by establishing a positive feedback signaling.
Moreover , AD and MCI ɛ4 carriers possessed the smallest hippocampal volumes and control ɛ2 carriers possessed the largest hippocampal volumes.
Moreover , adaptation to constitutive RAS activation in mice results in a better glucose tolerance.
Moreover , a decrease in stimulus processing speed was observed as a function of age.
Moreover , adequate walking speed is crucial to maintain older pedestrians ' mobility and safety in urban areas.
Moreover , a disease-causing C9orf72 repeat expansion mutation was later on identified in this patient.
Moreover , advanced age or mounting of strong CMV-specific responses impact independently on CD4 ( + ) T-cell counts and recovery with antiretroviral therapy.
Moreover , advances in Carotid Angioplasty and Stenting ( CAS ) techniques have resulted in perceived improved safety of this procedure.
Moreover , aerobic exercise interventions reduce arterial stiffness and restore vascular endothelial function in previously sedentary middle-aged / older adults.
Moreover , after artificial aging , the Creos and BioGide membranes showed sufficient resistance , while Smartbrane showed equivocal data after eight weeks.
Moreover , after the age of menopause , the incidence of chronic inflammatory disease in women approaches or exceeds that observed in males.
Moreover , aged C1q-deficient mice exhibited significantly less cognitive and memory decline in certain hippocampus-dependent behavior tests compared with their wild-type littermates.
Moreover , age differences were also found in relation to sequential complexity within the motor and attentional systems , reflecting both compensatory and de-differentiation mechanisms.
Moreover , AGE-induced premature senescence was mimicked by ER stress inducers and ATF4 overexpression , while suppressed by p16 gene silencing.
Moreover , age is inversely related to serum RNase-L levels in various analyses.
Moreover , aging and apolipoprotein E ( ApoE ) may be involved in the myelin impairments observed in patients with AD.
Moreover , aging at home in Francophone minority communities is a major challenge in rural areas.
Moreover , aging decreases alveolar macrophage phagocytosis of apoptotic neutrophils , downregulates the scavenging receptor CD204 , and induces retention of neutrophils during influenza infection.
Moreover , aging is associated with a state of chronic inflammation , influencing life expectancy.
Moreover , aging-related sarcopenia may further aggravate the muscle wasting process associated with chronic diseases and cancer.
Moreover aging studies of encapsulated RNA simulating up to @number@ years storage at room temperature show no bias in quantitative outcome.
Moreover , a GLUT5 knockout mouse has displayed the hallmarks associated with profound fructose malabsorption.
Moreover , a good deal of this volunteering takes place in religious institutions.
Moreover , alcohol consumption has also been reported to be associated with mortality.
Moreover , alexithymia features seem to be similar in people mild Alzheimer's disease and in mild cognitive impairment.
Moreover , all these effects were greatly amplified by combination of NADPH and apocynin.
Moreover , all volunteers had blood samples collected for lipid profile , glycemic control , and C-reactive protein analyses.
Moreover , a maximum hyoid position in healthy individuals of either gender does not differ depending on their jaw opening force.
Moreover , among obese older adults , dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure.
Moreover , among West German women , having had a non-marital first birth is weakly correlated with poorer physical health.
Moreover , analyses showed significant associations of the FaB-FC scores with fear of falling and balance confidence scores , attesting to its construct validity.
Moreover and consistent with the concept of mitohormesis , glaucarubinone extends C. elegans lifespan when applied at a concentration of @number@ or @number@ nanomolar.
Moreover , an enhancement of leptin receptors was found in hippocampus of young Tg2576 mice and in primary astrocytes and neurons treated with Aβ₁₋₄₂.
Moreover , an impaired function of innate immune cells indicate a predominance of zinc deficiency in the elderly that may contribute to immunosenescence.
Moreover , an increasing proportion of new HIV diagnoses are made in people older than @number@ y.
Moreover , antioxidant treatment using EGCG effectively protected cells from H₂O₂-induced injury , increasing cell viability from @time@ %±2.31% to @number@.77%±4.58%.
Moreover , antiretroviral medications and HIV itself might play a role in further increasing cardiovascular risk.
Moreover , an understanding of the variations in second cancer risk according to age at treatment is important in customizing patient follow-up.
Moreover , an update regarding the main Food and Drug Administration ( FDA ) approved fillers is presented.
Moreover , apigenin also decreased the MDA level and elevated SOD and CAT activities.
Moreover , APOE-ε4 promotes fertility in highly infectious environments.
Moreover a positive long-lasting effect was observed @number@ weeks after the last BCP administration ( p < @number@ ) .
Moreover , a potential effect on the level of physical activity , frailty , quality of life , and mobility was observed.
Moreover , approximately one-fourth of the subjects had an elevated SL and approximately one-tenth a high AL.
Moreover , a recent study showed that acute diet-induced energy deficit also reduces pTAG.
Moreover , a reduction in carbohydrate intake ( ≤9.5 g / d ) resulted in increased TL among Ala carriers.
Moreover , ARE increased the both ROS production and mitochondrial damage.
Moreover , ART sensitized breast cancer cells to epirubicin chemotherapy.
Moreover , a significant inverse correlation ( r = -0.94 , p = 0.0001 ) between the percentage of diffuse colonies and ECO-f was found.
Moreover , a significantly positive correlation between TAC levels and Klotho concentrations was detected.
Moreover , a significant task demand / age interaction was found in functional connectivity within the anterior and posterior subnetworks of the verbal fluency network.
Moreover , as in many situations where other cooperative behavior arises , senescence can be stabilized in a structured population.
Moreover , a small subgroup of normal controls also had problems with RL.
Moreover , as predicted , implicit theories did not predict younger adults ' memory performance.
Moreover , assays of nucleosome assembly in vitro demonstrate that JDP2 also has histone-chaperone activity.
Moreover , a statistically significant increase in CD44 expression was noted in the epidermis of C-xyloside-treated compared to the placebo treated skin areas.
Moreover , a subgroup of individuals with obesity does not seem to be at an increased risk for metabolic complications of obesity.
Moreover a subset of the @number@ features was considered to be significantly different between the two groups using a t-test.
Moreover , autophagy is functionally connected to the endocytic pathway as components of the endosomal trafficking are involved in the maturation of autophagosomes.
Moreover , AβpN3 was the main component of the SP that developed in very old dogs.
Moreover , bacterially expressed matrilin VWA domains differ in their solubility and functional properties from the same domains expressed in eukaryotic cells.
Moreover , baicalin pretreatment can effectively inhibit Aβ-induced phosphorylation of JAK2 and STAT3.
Moreover , BALB-neuT mice displayed slow tumor growth as compared to control group ( p < @number@ ) .
Moreover , base excision repair capacity increases with age without the increase of oxidative damage to DNA.
Moreover , baseline BMI and sex for all subjects , and smoking and V1a receptor polymorphisms for men , were associated with adherence.
Moreover , B cells with these general features are associated with viral infections and autoimmunity in both mice and humans.
Moreover , because age is the most significant risk factor for cancer , the majority of cancer survivors are over @number@ years of age.
Moreover , because the INR reversal rate is slower , hemorrhage risk is prolonged.
Moreover , BET stimulates muscle differentiation via insulin like growth factor I ( IGF-I ) .
Moreover , bHLH activity is a critical node coordinately regulating human PDA cell growth versus cell fate.
Moreover , biological changes that lead to the loss of muscle mass and strength are intrinsically related to the mechanisms of aging.
Moreover , biomarkers of glucose metabolism ( fasting glucose , fasting insulin , albumin , and HOMA index ) were extracted when possible.
Moreover , biomechanical material properties have been monitored to investigate the changes of vertebral bone with age.
Moreover , Bmi-1 inhibited Ets-1-mediated p16 ( INK4a ) upregulation.
Moreover , bmk-1 over-expression increases the level of hsp-16 and decreases ced-3 in C. elegans.
Moreover body fat distribution changes with adverse metabolic profiles and increased cardiovascular risk.
Moreover , bone marrow-derived progenitor cells would give significant information to wound age determination.
Moreover , BoNTA-familiar participants demonstrated sustained improvement in QOL and self-esteem relative to BoNTA-naïve participants , even when injected with placebo.
Moreover , both the appearance of senescent cells and the deficiency in DNA repair were observed.
Moreover , both these SNPs affect creatinine levels suggesting a possible influence on renal function.
Moreover , brain and heart became heavier as one got older and most organs were heavier in middle-aged individuals compared to other age groups.
Moreover , brain-centered glucoregulatory and immunomodulating systems that mediate peripheral health benefits of intermittent energetic challenges have recently been described.
Moreover , BRF1 mutations reduce Pol III-related transcription activity in vitro.
Moreover , BTX-A , which has a high molecular weight , does not appear to cross the placenta.
Moreover , by dividing our patients into tertiles based on age reached , this difference was more remarkable the higher the age reached.
Moreover , by regulating gene expression , H2 functions as an anti-inflammatory , antiallergic , and antiapoptotic molecule , and stimulates energy metabolism.
Moreover , by the disease , the highest expenditure was incurred by non-communicable diseases.
Moreover , Ca2 + levels and calpain activity were dramatically raised in the dying cells killed by detergent.
Moreover , CALCC was significantly thinner than TALCC ( P = @number@ ) .
Moreover , cardiorespiratory fitness appeared to mitigate age-related changes in BOLD during working memory in this region.
Moreover , cardiovascular abnormalities may be at least partially reversed by testosterone replacement therapy ( TRT ) .
Moreover , cardiovascular risk factors are linked to cognitive impairment and dementia.
Moreover , care-related personality change was affected by sex and age.
Moreover , CA revealed that the volatile composition of the non-thermal accelerated aged wines differs from that of the conventional aged wines.
Moreover , cell culture studies were carried out to examine if estrogen at physiological and non-physiological concentrations regulates hepatocyte PCSK9 expression.
Moreover , cell membrane capacitance of DF from elderly donors is smaller with respect to young donors and centenarians.
Moreover cells obtained from older patients displayed senescence associated features , for example , β-galactosidase activity , enlarged morphology , and p53 protein upregulation.
Moreover , changes in household structure may affect influenza transmission.
Moreover , changes in necrosis as a function of age have not been studied in human lymphocytes.
Moreover , changes in the brachial artery antegrade shear rate and the retrograde shear rate correlated with the change in brachial artery IMT.
Moreover , changes in trail-making performance and well-being could be predicted by the intervention-induced changes in ALFF.
Moreover , changes of TOLLIP expression might be associated with progression of ALS.
Moreover , children in their early teens ( i.e. , youth ) already show mature motor network patterns while their cognitive networks are still developing.
Moreover , CHIP partially translocates to the nucleus and acquires higher ubiquitination levels in senescent cells.
Moreover , CH uptake significantly decreased both proenzyme and active forms of MMP2 compared with casein and control groups ( P < @number@ ) .
Moreover , cilengitide , an αvβ3 antagonist , has the ability to block the senescence-associated secretory phenotype ( SASP ) without affecting proliferation.
Moreover , Cisd2 protects mitochondria from age-associated damage and functional decline as well as attenuating the age-associated reduction in whole-body energy metabolism.
Moreover , class separability , measured by a divergence criterion , was substantially higher when using the combination of activation maps.
Moreover , clinical evidence has shown that vitamin D deficiency is associated with alcoholic and non-alcoholic fatty liver diseases.
Moreover , clinical interventions to improve physical performance could also reduce the risk of future fractures.
Moreover , clinical studies have shown that treatment of hyposalivation diminishes hypogeusia , indicating that salivation is essential to maintain normal taste function.
Moreover , CL is involved in different stages of the mitochondrial apoptosis process as well as in mitochondrial membrane stability and dynamics.
Moreover , cognition was not related to changes in WC.
Moreover , cognitive functioning appears to partially mediate this relationship.
Moreover , cognitively frail individuals showed a difference ( p < .001 ) in disability in comparison with non-frail participants.
Moreover , cognitive performance on several tasks can be classified in three levels as a function of Information score.
Moreover , cognitive rehabilitation appears to be a very successful intervention for patients with NCI who experience subjective complaints and participation restrictions.
Moreover , combining multi-modal neuroimaging and multi-view data integration techniques allows generating multiple independent connectivity features for the same patient.
Moreover , communities were categorized on a rural-urban continuum.
Moreover , comparable induction of transcripts involved in epithelial to mesenchymal transition was observed in both cell types.
Moreover , compared with the controls , the aerobic training group demonstrated reduced activation in the left lateral occipital cortex and right superior temporal gyrus.
Moreover , complexin levels showed distinct patterns of change related to memory challenges in a rat model , supporting the functional specificity of these proteins.
Moreover , compound @number@ showed inhibition activity on elastase , a protease enzyme capable of degrading elastin.
Moreover , compounds 2b , 3e and 12e were tested for their activity in human skin biopsies.
Moreover , corpus-based frequency values and word length are provided as objective psycholinguistic measures of the nouns.
Moreover , co-transfection of SVBP significantly augmented the inhibitory effect of VASH1 on EC migration.
Moreover , cranberry improved survival of sod1 knockdown and dfoxo mutant flies but did not increase wild-type fly's resistance to acute oxidative stress.
Moreover , CR in human beings improves markers of cardiovascular aging , and rejuvenates the skeletal muscle transcriptional profile.
Moreover , CR opposes the expected age-associated alterations in myocardial stiffness , autonomic function , and gene expression in the human skeletal muscle.
Moreover , cultivating student nurses ' positive attitudes about geriatrics and relieving anxiety about aging could be beneficial.
Moreover , cumulative self-oriented events accounted for a larger percentage of variance in symptom severity compared to events directed at others.
Moreover , current scholars are aging , and there is a looming shortage of scholars prepared for the future.
Moreover , CXCL10 expression correlates with JAK2V617F allelic burden.
Moreover , CYP2D6 inhibitors more strongly affect risperidone metabolism than that of its metabolite.
Moreover , cytosolic chaperones are consistently elevated in nerves from neuropathic mice , with the most prominent change in HSP70.
Moreover , cytotoxicity evaluation , by MTT assay and cell cycle analysis , was performed at various points of time after the treatment.
Moreover , damage by free radicals is connected to impaired circadian rhythmicity.
Moreover , data obtained in different models of cellular aging are compared.
Moreover , Dbl knock-in male mice displayed an increased incidence of lung adenoma compared to w.t. mice.
Moreover , degenerative changes in various tissues / organs have been attributed to derangement of stem cell functions causing regenerative tragedy.
Moreover , delta ERO responses decreased in accordance with age.
Moreover , depletion of α5 led to a severe drop in the amounts of active EGFR.
Moreover , depression was associated with patients ' overestimation of symptoms.
Moreover , depressive-like behaviors were observed in the hypoxic rat.
Moreover , despite increases in the complexity and cost of health care , reimbursement for some services has been reduced or denied.
Moreover , despite the functional relevance of the hand in activities of daily living , age-based models of distal proprioception are scarce.
Moreover , diagnosis of some pRCC , especially pRCC of type @number@ ( pRCC2 ) may be challenging.
Moreover , differentiated keratinocytes in organotypic airlifted three-dimensional cultures were transduced following topical vector application.
Moreover , different oxidative lesions in mitochondrial DNA are between 5- and 10-fold higher than in nuclear DNA in both control and AD postmortem brains.
Moreover , Dil labeling was administrated to trace the homing of the transplanted stem cells.
Moreover , direct interaction of circRNA 100269 and miR-630 was confirmed through dual-luciferase assays.
Moreover , disruption of caveolar integrity prevents injury-elicited NO signaling , but not the accompanying Ca²⁺ response.
Moreover , disruption of senescence by miR-17-92 or its miR-17 / 20a components leads to enhanced oncogenic transformation by activated ras in primary human cells.
Moreover , disruption of the PKA-AKAP interaction reduced these morphometric parameters.
Moreover , divine control beliefs are more strongly associated with mattering among women , African Americans , and individuals with less education.
Moreover , DLK1 ( PREF1 ) could be a functional marker contributing to the characterization of human ASC.
Moreover , due to referral bias the decrease in specificity in the elderly may even be underestimated.
Moreover , due to their influence on fertility , both genes may be part of the longevity-fertility trade-off mechanism.
Moreover , during adrenergic blockade differences in calf venous compliance between young and older men observed before adrenergic blockade persisted.
Moreover , early filling peak velocities showed a higher response in the CTL than EG group.
Moreover , ectopic CELF1 overexpression caused G1-phase growth arrest , whereas CELF1 silencing promoted cell proliferation.
Moreover , EEG-based NF was related to an increase in task-specific activity when compared to the absence of feedback in both older and younger adults.
Moreover , efficient intra-neuronal uptake of oAβ and oTau requires expression of APP.
Moreover Egr-1 appears to be required for physiologic and pathological connective tissue remodeling , and Egr-1-null mice are protected from fibrosis.
Moreover , elderly humans fair worse after acute diseases , namely infection , leading to higher rates of infection-mediated mortality.
Moreover , elderly patients have significantly decreased reserve functions of various organs , reducing their tolerability to treatments for liver diseases.
Moreover , elderly patients may sometimes prioritize maintaining quality of life above prolonging survival.
Moreover , elderly subjects responded with longer time lags during saccadic target shifts and executed more catch-up saccades during smooth pursuits than younger subjects.
Moreover , emotional complexity was negatively related to psychological distress among those feeling closer to death.
Moreover , empirical results differ between studies.
Moreover , EMS effectively inhibited TNF-α-induced expression of MMP-1 via the NF-κB pathway.
Moreover , EMS reduced the level of nuclear p65 protein in HDFs.
Moreover , endothelial stiffening reduces nitric oxide production , which promotes smooth muscle cell contraction and vasoconstriction.
Moreover , endurance training induces adaptations that result in an enlargement of the IB phase independent of age.
Moreover , environmental exposure and risk disparities are associated with different social determinants , including socioeconomic status ( SES ) and demographic indicators.
Moreover , enzyme-linked immunosorbent assay further confirmed that BMSCs secreted much more VEGF , and PMSCs secreted much more HGF and PGE2.
Moreover , ethnic-specific cutoffs , the lowest quintile for each parameter , predicted the higher risk of mortality than the FNIH-recommended values.
Moreover , evidence indicates that a combination of pharmacological and non-pharmacological interventions could provide greater relief of clinical symptoms than either intervention given alone.
Moreover , executive performance was linked to subsequent quality of life in men.
Moreover , exercise and phytoestrogen may interfere in the improvement of climacteric symptoms in the long term.
Moreover , exercises shaping lumbar lordosis should be performed to prevent its flattening.
Moreover , exogenous progenitors of bone marrow origin transdifferentiate and acquire the cardiomyocyte and vascular lineages.
Moreover , exposure to other metals than Pb should be considered.
Moreover , expression of the β-C-terminal fragment ( β-CTF ) of APP was markedly low in the mitochondria-enriched fraction.
Moreover , extracellular matrix components changes may contribute to muscle myopathy during SAHS progression.
Moreover , extracellular vesicle-based therapeutics are being developed and clinically tested for the treatment of inflammatory diseases , autoimmune disorders and cancer.
Moreover , facelifting operations can result in disproportionate or poorly positioned earlobes.
Moreover , face validity of the inversely phrased items in particular appeared to be weak.
Moreover , feasible suggestions on precision healthcare and healthy longevity are kindly proposed based on the comprehensive review of current studies.
Moreover , female smokers with low KCO , had lower BMD and shorter TL compared to those with normal KCO.
Moreover , ferulate inhibited epithelial cell leakage induced by t-BHP , which was accompanied by decreased expression of the TJ proteins zonula occludens-1 and occludin.
Moreover , few interventions have utilized the family unit.
Moreover , fiber-type-specific and overall capillarisation as well as fiber composition were additionally assessed in Vlat biopsies obtained from CEUS site.
Moreover , fidelity of this pathway has been shown to decline with age.
Moreover , findings point out the implication of some endogenous compounds in protection from life-threatening arrhythmias via preservation of myocardial connexin.
Moreover , findings suggest the need for re-thinking hetero-normative definitions of \ "community \ " in the context of LGBTQ aging.
Moreover , finer measures of learning captured by serial position scores were the most sensitive predictors of AD dementia.
Moreover , fitness decline begins long before oncological diseases have fatal effects in significant numbers.
Moreover , for each gene analyzed in the pro-antioxidant pathway , we tested the influence on longitudinal survival.
Moreover , for older adults , more years of education was associated with a weaker across-hemisphere advantage.
Moreover , FPKc provoked only little damage on normal cells in vitro and also on normal tissues in vivo.
Moreover , frailty and EATVi are associated with impaired cell membrane integrity and function assessed by PA.
Moreover , FR during real and simulated night shifts was more perturbed in those who started shift work at older ages.
Moreover , functional characterization of this variant showed that it is responsible for the inhibition of the MAPK / ERK1 / 2 pathway.
Moreover , functional interactions between carbonylated proteins of kinetochore / spindle machinery and centrosome organization were significantly enriched.
Moreover , future approaches to SE should define the concept in such a way that it is applicable to every individual regardless of employment status.
Moreover , future directions of deep brain stimulation and the usability of patient controllers are discussed.
Moreover , gender differences were indicated by individual item reliability scores , mean score , and prevalence rate of depressive symptoms.
Moreover , genes coding for CK2 and thymosine beta-10 were significantly up-regulated , however , that coding for RACK1 was down-regulated.
Moreover , genes involved in the regulation of chromatin structure ( PRMD8 , KDM2B , TET1 ) showed altered methylation.
Moreover , genes showing differential hydroxymethylation were significantly enriched in neurobiological processes and clustered in functional gene ontology categories.
Moreover , genetic or pharmacological manipulations that extend lifespan in model organisms often activate autophagy.
Moreover , greater familiarity with idioms was associated with better understanding in adults.
Moreover , growing evidence reveals the regulation of cardiac and circulating microRNAs in response to exercise.
Moreover , GSH's intracellular content was so high that it always saturated GSTP1-1.
Moreover , GSN also regulates cell morphology , differentiation , movement , and apoptosis.
Moreover , GTP-bound Rheb interacts with BACE1 and degrades it through proteasomal and lysosomal pathways.
Moreover , H2O2 also promoted HUVEC aging.
Moreover , half of the older drivers reported having started using @number@ or more compensatory strategies.
Moreover , HCT116 p21- / - , HeLa and Saos-2 cells depleted of p21 encounter problems in chromosome segregation and cytokinesis.
Moreover , health care professionals ' attitudes can be tainted with ageism , thus leading to undesirable consequences for patients.
Moreover , healthy gingiva ( non injury ) shows less staining compared to a wound site , suggesting a role in wound healing.
Moreover , hemoglobin concentration was measured at follow-up , and changes in concentration from baseline to follow-up were investigated.
Moreover , high densities of hypertrophic astrocytes are observed in the dentate gyrus of APPxPS1 females specifically.
Moreover , high expression levels of both AR and IL6 in human ESCC predict poor clinical outcome in tobacco users.
Moreover , high fat or high sugar ( fructose , glucose , or sucrose ) impart a significant impact on bone structural integrity.
Moreover , HS-1793 showed more potent effects than resveratrol on the cytotoxic effects on PC-3 cells.
Moreover , HT inhibited prostaglandin ( PG ) E2 production and COX-2 expression , without affecting COX-1.
Moreover , if the causal SNPs are not genotyped , GCTA sometimes greatly underestimates the true heritability.
Moreover , Immunobloting analyses using an antibody that recognizes p70S6K1 phosphorylated at Thr389 showed that niacin evoked p70S6K1 activation via the PI3K / Akt pathway.
Moreover , impaired recognition of disgust was associated with decreased gray matter volume in the bilateral ventroanterior and ventral middle regions of the insula.
Moreover , impairing IL-7-mediated signaling is sufficient to promote selection for Bcr-Abl-expressing B progenitors.
Moreover , in all age groups , individuals with higher variability in medial frontal stimulus-locked theta oscillations showed higher trial-to-trial RT variability behaviorally.
Moreover , in all four groups , we found evidence for audio-visual integration.
Moreover , in both tasks , older participants were less able to increase RT benefits with longer PIs , revealing a deficit of response facilitation.
Moreover , increased expression of miR-29b in human cortical tissue was negatively correlated with IGF-1 and CX3CL1 expression.
Moreover , increased levels of ROS may also activate proteolytic systems , thus leading to enhanced protein breakdown in several models.
Moreover , increased Rrm2 gene dosage significantly extends the life span of ATR mutant mice.
Moreover , increased T cell differentiation was observed with higher percentages of CD57 + and CD28null CD4 + and CD8 + memory T cells.
Moreover , increases in impedance were correlated with reductions in CBF velocity.
Moreover , increasing age decreased the social support score in the total sample and in both sexes.
Moreover , increasing age was related to decreasing temporal pole cortical thickness in the monolingual group , but no such relationship was observed for bilinguals.
Moreover , increasing concentrations of gold nanoparticles exhibited a pronounced reduction in AGE formation.
Moreover , increasing epidemiological studies indicate that there is a significant association between T2DM and Alzheimer's disease ( AD ) .
Moreover , increasing evidence suggests that genetic programs normally active only during development of human beings may be reactivated during tumorigenesis.
Moreover , increasing severity of SVD markers was independently associated with worse performance on MMSE and MoCA.
Moreover , indirect effects of trait Harm Avoidance significantly attenuated the direct effects of parental overprotection and care on perceived stress.
Moreover , individual-level income and education no longer predicted self-rated health once age-friendly environment factors were taken into account.
Moreover , individuals with fully restricted social networks are at particular risk due to heightened health needs and limited social resources.
Moreover , induction of E47 in human PDA cells in vitro is sufficient to inhibit tumorigenesis.
Moreover , inhibition of caspase-1 activity repressed adipogenic differentiation and partially improved osteogenic differentiation of MSCs with LPS / PA treatment.
Moreover , inhibition of endogenous CREBH expression by siRNA attenuated ALA-induced FGF21 expression.
Moreover , inhibition of αvß3 with echistatin or with αvß3-blocking antibody increased senescence of SMCs on wild-type collagen.
Moreover , in microarray studies , we found FKBP1b gene expression was downregulated in hippocampus of aging rats and early-stage Alzheimer's disease subjects.
Moreover , in older patients increased sensitivity to warfarin resulting in increased risk of bleeding has been previously documented.
Moreover , in replicative human senescent fibroblasts , DDR precluded MYOD-mediated activation of the myogenic program.
Moreover , in SIPS , proteasome / ubiquitin ligase pathways of protein degradation dominate the regulatory landscape.
Moreover , insomnia severity groups and score on the PSS each revealed a significant main effect on serum BDNF levels.
Moreover , insulin signaling is also involved in the mechanism of aging , decreasing with an increase in age.
Moreover , interaction between Aβ and τ proteins could be cause of neuronal loss.
Moreover , in the rat , they form a bilateral , interconnected network that projects to NK3R-expressing GnRH terminals in the median eminence.
Moreover , in these animals , sunitinib reduced the hyperactivation of CDK5 , tau hyperphosphorylation , and p35 cleavage to p25.
Moreover in the subgroup analysis , higher concentrations of IL-23 were identified in patients of older age ( ⩾40 years ) and female gender.
Moreover , in the younger adults , saccades that followed the gaze were initiated more rapidly , illustrating the reflexive nature of gaze following.
Moreover , intra / extracellular miR-126-3p levels were measured in human endothelial cells ( HUVECs ) undergoing senescence under normo / hyper-glycemic conditions.
Moreover , intraoral aging affects the biologic properties of materials.
Moreover , investigations on how to develop Fuzi׳s new clinical usage on the basis of its pharmacological effects are in requirement.
Moreover , in vitro cell expansion is needed to obtain the number of cells necessary for clinical developments.
Moreover , involving both older adults and their caregivers for the participation this program is recommended for a greater impact.
Moreover , I propose a strategy how we might integrate the novel agents for CLL therapy into sequential treatment approaches in the near future.
Moreover , I propose a strategy how we might integrate the novel agents for CLL therapy into sequential treatment approaches in the near future.
Moreover , ischemic neurodegeneration is strongly accelerated with aging , too.
Moreover , isolated monocytes were tested for ex-vivo LPS-stimulated TNF-alpha production and TNF-alpha mRNA.
Moreover , it actively loads RPA onto nascent ssDNA.
Moreover , it also decreased hippocampal acetylcholinesterase activity and lipid peroxidation product formation.
Moreover , it has been reported that chronic nutritional stress is associated with epigenetic alterations in mechanisms of gene regulation during pancreatic development and function.
Moreover , it has confirmed that dermohypodermitis are the most frequent skin diseases among geriatric patients hospitalized in Mali.
Moreover , it increased fluorescence amplitude , maximal rate of rise of fluorescence and reduced time to peak fluorescence.
Moreover , it is also plausible that the presence of large structural events could be associated with cancer risk.
Moreover , it is also related to some metabolic diseases such as diabetes and to some side effects of drug treatments.
Moreover , it is argued this consistency has shaped an implicit prototype causing followers to associate older age with dominance leadership.
Moreover , it is associated with increased susceptibility to infectious , autoimmune , and neoplastic processes.
Moreover , it is important to detect those MCI patients who are at particularly risk for developing dementia.
Moreover , it is interesting to speculate whether cell density changes in vivo may also affect AβPP processing and Aβ levels in the AD brain.
Moreover , it is now understood that the barriers of the brain are not uniform in their interactions with the circulating immune cells.
Moreover , it is suggested that the baroreceptor reflex is involved in long term blood pressure regulation.
Moreover , it may regulate the adipogenic and osteogenic differentiation of MSCs.
Moreover , it produced an epidermal differentiation defect evidenced by the lack of loricrin and filaggrin expression in the epidermis.
Moreover , it regulates the chronic type of stress associated with aging.
Moreover , it remains to be seen if selective enzyme inhibitors have therapeutic utility in the treatment of HD by reducing oxidative stress locally.
Moreover , it remains unclear if this intra-islet cell conversion is relevant to diseases like type @number@ diabetes ( T1D ) .
Moreover , it remains unclear whether the influence of aging on global or regional cortical thickness differs between schizophrenia patients and healthy controls.
Moreover , it seems that intermittent MDMA treatment attenuates the morphological signs of aging in serotonergic fibers.
Moreover , it seems that this outcome is more a case of \ "the lower the better. \ "
Moreover , it showed that the discrimination ability and the reproducibility of the proposed index are comparable or larger than those of traditional indices.
Moreover , it summarizes findings regarding proteasome activation in the major age-related diseases as well as in progeroid syndromes.
Moreover , its well-known target , the longevity-associated protein SIRT1 , was significantly downregulated during aging in both endothelial cells and vascular smooth muscle cells.
Moreover , it was checked if possible eligible patients coming to the hospital were indeed screened for participation.
Moreover , it was supposed that αS oligomer concentration was also elevated in blood of PD patients.
Moreover , it will help greatly in the planning of both surgical and conservative strategies.
Moreover , keratinocytes and neurons show some similarities of electrochemical behaviour.
Moreover , Klotho protects against several pathogenic processes in a FGF23-independent manner.
Moreover , knockdown of SRF in hDE-MSCs resulted in decreased expression of SkM-related genes after in vitro differentiation and decreased in vivo engraftment.
Moreover , Lamin A / C expression can be restored with a demethylating agent.
Moreover , LBPs exhibit hypolipidemic , cardioprotective , antiviral , and antiinflammatory activities.
Moreover , LDMC contributes to therapeutic efficacy by inhibiting the recruitment of protumorigenic bone marrow-derived myeloid cells.
Moreover , level of mRNA ho-1 expression in PBMCs from patients with BD was reduced.
Moreover , lifestyle intervention studies revealed discordant responses of mitochondrial oxidative capacity and insulin sensitivity.
Moreover , lipid and glycogen content was increased in hearts derived from Ngb-overexpressing mice.
Moreover , little effort has been done to investigate the potentially beneficial effects of specific exercises to counteract the CIPN symptoms.
Moreover , little is known about the computational mechanisms mediating differences in learning styles.
Moreover , little is known about the effect of R-SFN on stem cells whose longevity is implicated in human aging.
Moreover , little is known about the effects of chronic low-dose exposure.
Moreover , little is known about the underlying mechanisms between social support and cognitive functioning.
Moreover , little is known regarding the ways in which the broader public views and enhances aging with dignity and independence with their older residents.
Moreover , liver injury , collagen content , and hepatic stellate cell activation were equally severe in wild-type and COX-2 Tg mice.
Moreover , long-term care providers could benefit from joint provision of care and services by means of modular working teams.
Moreover long-term stress as well as physiological aging result in hormonal and immunological disturbances including axis depletion , regulatory T-cell accumulation and dehydroepiandrosterone decrease.
Moreover , loss of Marf leads to a severe depletion of mitochondria in neuromuscular junctions ( NMJs ) .
Moreover , low T ( b ) has been shown to improve health and longevity independent of CR.
Moreover , LYC treatment activated the mRNA expressions of antioxidant enzymes HO-1 and NQO-1 , and downregulated inflammatory cytokines IL-1β and TNF-α in mice hippocampus.
Moreover , male carriers of C + allele are more prone to reach centenarian age than C- ones.
Moreover , many investigations have found no significant differences in latencies with advancing age.
Moreover , many of these DRP can be avoided.
Moreover , many types of cells have receptors that can measure AGE level.
Moreover , markers of senescence were also present in human and murine TPP2-deficient fibroblasts.
Moreover , medical pathologies in elderly patients often have a multi-factorial etiology and many psychopathological dimensions and psychosocial risk factors are underestimated.
Moreover , melatonin and its metabolites modulate a large number of antioxidative and pro-oxidative enzymes , leading to a reduction in oxidative damage.
Moreover , men with elevated serum testosterone levels and associated gene signatures exhibited the lowest antibody responses to TIV.
Moreover , meta-analysis indicated that ACE D allele has some selective advantage that contributes to longevity in majority of European populations.
Moreover , mGlu3 receptor expression is also decreased specifically in hippocampal astrocytes of these transgenic animals as a function of age.
Moreover , MGO significantly decreases the proteolytic activity of the 20S proteasome.
Moreover , mice expressing hTDP-43-ΔNLS exhibited profound changes in gene expression in cortical neurons.
Moreover , microglia activity is not limited to proinflammatory responses , but covers a spectrum of reactive profiles.
Moreover , miR-126-3p expression was down-regulated in intermediate-age HUVECs grown in high-glucose medium until senescence.
Moreover , miR-216a stimulated ox-LDL accumulation and monocyte adhesion in HUVECs.
Moreover , MLCK and ROCK inhibition were equally effective in reducing carbachol-induced contractions.
Moreover , moderate cardiac-specific knockdown of integrin-linked kinase ( ILK ) / integrin pathway-associated genes also prevented the decline in cardiac performance with age.
Moreover , moderate to significant interaction between different loci were observed for the entire PD cohort or late onset PD only.
Moreover , molecular modeling of emoghrelin docking to the ghrelin receptor was exhibited to explore the possible interaction within the binding pocket.
Moreover , more pronounced reductions in SBP and DBP were observed in the UH patients compared to TH and N subjects.
Moreover , MPI showed a greater discriminatory power than organ-specific prognostic indexes such as the estimated glomerular filtration rate.
Moreover , MPTs make explicit the assumptions behind different ways to parameterise Item and Source memory.
Moreover , multimorbidity was related to the degree of worrying about memory complaints in people who perceived themselves as forgetful.
Moreover , multiple lines of evidence increasingly link mutations and dysregulations of lncRNAs to diverse human diseases , especially disorders related to aging.
Moreover , muscle myofibrillar protein synthesis and tendon collagen morphology were determined.
Moreover , mutations of Context : Obstructive sleep apnea ( OSA ) is associated with diabetes and cardiovascular disease.
Moreover , myelin-associated lipids robustly triggered TREM2 signaling in vitro , suggesting that TREM2 may directly sense lipid components exposed during myelin damage.
Moreover , nearly one fifth of children had elevated Hcy.
Moreover , nebivolol appears to be significantly cost-effective when prescribed in these patients.
Moreover , nebivolol significantly reduced the diameter of lipid droplets in cultured adipocytes.
Moreover , negative control attempts predicted greater negative affective responses ( e.g. , resentment , sadness ) .
Moreover , Neil2-null mice are much more responsive to inflammatory agents than WT mice.
Moreover , neurofibrillary degeneration was characterized by extensive formation of sarkosyl insoluble tau protein complexes consisting of rat endogenous and truncated tau species.
Moreover new approaches are required for prevention of the disease.
Moreover , new muscle mass index , ASM / BMI , provided better prognostic values than ASM / height2 in all associations.
Moreover , nickel and cobalt treatment increased sumoylation and mono-ubiquitination of @date@ and K123 was crucial for mediating these modifications.
Moreover , NIMNRF produced minimal complications and downtime as well as few side effects.
Moreover , no differences of 1-year major adverse cardiac events ( MACE ) were observed between KOD and IOD patients.
Moreover , no difference was observed between men and women regarding subjective sleep quality.
Moreover , no group difference emerged in the offspring groups.
Moreover , no mutation screening study has been performed yet employing large population in Korea.
Moreover , none of these proteomic studies has used a global quantitative labeled proteomic offgel approach that allows a more accurate description of aging phenotype.
Moreover , no previous study has assessed the influence of health status on this association.
Moreover , normative data for serial testing may now be collected to assess normal learning curves as important comparative readout of pathological cognitive processes.
Moreover , no study has yet comprehensively explored epigenetic drift at different genomic length scales and in relation to regulatory elements.
Moreover , Numb depletion induced elevation of lysosomal pH values and decrease of glycosylated lysosome-associated membrane proteins.
Moreover , @number@ women asked to be included in the study on a voluntary basis , and were analyzed separately.
Moreover nutrition as a therapeutic intervention in alcoholic liver disease has been discussed.
Moreover , OA often coexists with other morbidities in the same patient , which in turn condition the OA process.
Moreover , OB-plasma increased NF-κB activation and its nuclear translocation.
Moreover , often , subjects are not long-term practitioners , but recently trained.
Moreover , older adult participants had significantly higher starting QF %MVIC as well as shorter task times.
Moreover , older adults demonstrated higher response accuracy than younger adults during the semantic task.
Moreover , older adults showed increased connectivity between the FPCN , supporting cognitive control , and somatomotor areas implicated in response selection and execution.
Moreover , older adults were consistently slower to initiate naming than were their younger counterparts across all conditions.
Moreover , older adults were more likely than younger adults to accompany these errors with remember judgments.
Moreover , older listeners are affected at lower presentation levels.
Moreover , older participants showed reduced relative activation in the right occipito-temporal source of mN2pc.
Moreover , older patients are commonly frail : they have substantial chronic co-morbid conditions including renal impairment and frequent acute illnesses and are often polymedicated.
Moreover , only @number@ % of EG reported falls previously , while CG reported @number@ % of falls during the same period of time.
Moreover , only older and middle-aged adults high in interdependence benefitted from having more peripheral social partners by showing decreased loneliness in the 2-year interval.
Moreover , our data identify mIndy as a target gene of IL-6 and determine novel functions of IL-6 through mINDY.
Moreover , our findings are consistent with previous studies that have suggested executive attention control may be the source of these individual differences.
Moreover , our gene expression databases can be used as a roadmap for future analysis of mechanisms of antioxidant action.
Moreover , our PDSs significantly improved endothelial cell viability , compared to glucose-based PDSs and basal condition.
Moreover , our results indicated that compound 8b induced apoptosis of HeLa cells , and activated caspase-9 and caspase-3 enzymes.
Moreover , our study showed no association between rs2153960 , rs7762395 or rs13220810 polymorphisms and longevity.
Moreover , overexpression of BMP2 in NPC cells promoted cell proliferation , migration , invasiveness and epithelial-mesenchymal transition ( EMT ) .
Moreover , overexpression of CCL5 increased tumor-associated angiogenesis and tumor growth by downregulating miR-199a in the xenograft tumor angiogenesis model.
Moreover , overexpression of miR-144 expression could suppress tumor growth in nude mice.
Moreover , overexpression of SIRT6 rescues the decline of BER in aged fibroblasts.
Moreover , PARP1 hypomorphy is associated with a higher risk for certain types of cancer.
Moreover , patients were not cognitively impaired [ SPMSQ ( short portable mental status questionnaire ) m ± SD = @number@ ± @number@ ] .
Moreover , patients with diabetes who further develop cancer have increased early and late mortality in comparison with cancer patients without diabetes.
Moreover , patients with dyspeptic symptoms are increasingly referred to the use of psychiatric and antianxiety drugs in addition to the primary medical treatment.
Moreover , patients with fibromyalgia present similar levels of functional capacity and physical condition than elderly people.
Moreover , patients with kidney disease are often affected by comorbid processes and are prescribed multiple medications.
Moreover , patients with nuclear cataract had the domination of parasympathetic nervous system and another character of dystrophic changes.
Moreover , PDE4B gene may be involved in the testicular abnormalities of men with DS and cryptorchidism.
Moreover , people considered as well nourished , eating significantly more energy than the others ( p = .04 ) .
Moreover , @percent@ of patients with TMJOA ( 88 / 156 ) remained stable.
Moreover , performance did not differ from that on a What-What-What control task.
Moreover , perfusion distribution varies as BMD decreases , especially at the area crossing the femoral neck to the shaft.
Moreover , perioperative and postoperative surgery complications as cardiovascular ones still occur.
Moreover , persons who were widowed and had experienced one or more negative life events were found to have a threefold risk for dementia.
Moreover , PET + patients were characterized by a higher circulating C-reactive protein.
Moreover , PGRN knockout mice exhibited accelerated IVD matrix degeneration , abnormal bone formation and exaggerated bone resorption in vertebra with aging.
Moreover , phase transitions occurred at lower frequencies for older participants and more transitions were observed for older than for younger participants.
Moreover , phosphodiesterase-5 inhibitors , that is , sildenafil blocked LPA-stimulated BPH SMC proliferation.
Moreover , physical activity levels are predictive of performance in measures of physical function and mobility in older men.
Moreover , physical examination , blood / urine glucose test , and diabetes-related autoantibodies investigations demonstrated that he had psoriasis and T2DM.
Moreover , PIIINP predicted future cancer.
Moreover , PKCβ inhibition can suppress 3T3-L1 cell differentiation in normal and FTO-overexpressing cells but not in FTO-silenced or -inhibited cells.
Moreover , Plin2 expression is inversely correlated with quadriceps strength and VL thickness.
Moreover PMAb83 abrogated the PAUF-induced angiogenic responses of endothelial cells , reducing the density of CD31 ( + ) vessels in the treated tumors.
Moreover , poor goal disengagement capacities and high levels of functional disability forecasted six-year increases in depressive symptoms.
Moreover , population variation in male reproductive senescence reveals phenotypic plasticity resulting from environmental , lifestyle , and genetic factors.
Moreover , postmortem brain samples from supercentenarians demonstrated relatively mild age-related neuropathological findings.
Moreover , postovulatory aging of oocytes impairs mitochondrial adenosine triphosphate production as a result of increasing oxidative stresses.
Moreover , P. pacificus could be tested successfully in sediments inhospitable to C. elegans.
Moreover , PPARs distribution were also followed in situ in adult mouse brains.
Moreover , prelamin A accumulation does not impair tumour initiation and growth , but it decreases the incidence of infiltrating oral carcinomas.
Moreover , prescribing of OACs among high-risk patients improved significantly ( @percent@ vs @percent@ , p = @number@ ) .
Moreover , processing of miRNAs appears to be altered by obesity , diabetes , and aging.
Moreover , prolonged autophagy inhibition in cortical neurons markedly increased p62 / SQSTM1 , supporting its degradation mainly by autophagy and not by proteasomes.
Moreover , propolis significantly reduced the P.g.
Moreover , protein expression of this variant in patient-derived fibroblasts disrupted binding to autophagy adapter proteins and inhibited the function of TBK1 in HEK293T cells.
Moreover , proteins of the kidney filtration barrier play important roles in both correct synapse formation , mechanosensation and signal transduction in the nematode.
Moreover , PS increased sarcomere length and decreased purge loss of LD significantly.
Moreover , PSLs inhibit the maturation of dendritic cells and osteoclast precursors.
Moreover , PWV frequently remains high in hypertensive patients despite adequate BP control.
Moreover , Q3GA significantly reversed scopolamine-induced reduction of Akt phosphorylation in the mouse hippocampus and ameliorated scopolamine-induced memory impairments.
Moreover , radial diffusivity was more reduced than axial diffusivity as local iron concentration increased.
Moreover , RAM decreased as the number of metabolic syndrome components increased ( p-value for trend < 0.01 ) .
Moreover , recent anti-Aβ immunotherapy clinical trials demonstrated efficient clearance of parenchymal amyloid deposits but have been plagued by CAA-associated adverse events.
Moreover , recent data point to that some mediators of the immune system affects the normal function of the clock.
Moreover , recent discoveries that HSF1 controls life span have prompted new ways of thinking about an old transcription factor.
Moreover , recent epidemiological studies suggest that SO is related to CVD and mortality.
Moreover , recent studies suggest that berberine could have a direct action on carbohydrate metabolism in the intestine.
Moreover , redox regulation affects Pin1 subcellular localization and Pin1-mediated neuronal survival in response to hypoxia treatment.
Moreover , regional vulnerabilities to Aβ deposition allow for more targeted investigation of early Aβ changes.
Moreover , ReHo demonstrated the same age-related differences as CMRGlu throughout all cortical regions , particularly in the default network and frontal areas.
Moreover , relaxin similarly promoted muscle healing in mice with aged muscle.
Moreover , research on PON1 attracted much interest following several studies indicating that it is involved in cardiovascular protection.
Moreover , restriction of glucose has been demonstrated to decrease the incidence of age-related diseases such as cancer and diabetes.
Moreover , results suggest that the former dimension may be more important than the latter , at least in the case of naming from definition.
Moreover , resveratrol , a plant polyphenol activator of SIRT1 , increases FoxO1-dependent SIRT1 transcription activity and thus induces its expression.
Moreover , Rhes-deleted mice are dramatically protected from neurodegeneration and motor dysfunction in mouse models of HD.
Moreover , rhythmic methylation of BMAL1 was altered in AD brains and fibroblasts and correlated with transcription cycles.
Moreover , ROS themselves are autocrine forward regulators of the immune response.
Moreover , S-ASCs showed a better colonization of the titanium scaffold.
Moreover , scientific initiatives to develop novel AD drugs are ongoing.
Moreover , screening methods for cutaneous therapeutics require accurate , unsupervised and high-throughput image analysis techniques.
Moreover , screening tools for the early detection of good or poor \ "storers \ " and donors have been developed.
Moreover , secreted IL-1β promoted endothelial cells senescence through up-regulation of p53 / p21 protein expression.
Moreover , serum concentrations of IL-6 , IL-β , CRP , TNF-sR1 and TNF-sR2 were assessed.
Moreover , several glycans in the AAT enriched fraction were associated with physiological parameters marking cardiovascular and metabolic diseases.
Moreover , several miRs involved in endothelial cell function have been identified.
Moreover , several proteins make use of weak multivalent interactions or conformational templating to drive the formation of large-scale assemblies.
Moreover , several therapeutic interventions are able to prematurely induce senescence.
Moreover , several years of research have demonstrated that mitochondria have a pivotal role in aging.
Moreover , SHP-1 depletion deletes verbascoside inhibitory effects on pro-inflammatory molecules induced by LPS.
Moreover , significant main effect of aging on movement times has been found in all four tasks.
Moreover , silencing of DIRAS3 results in a premature senescence phenotype.
Moreover , silencing RPS6KB1 or expression of a constitutively active PRKAA prevented autophagy suppression by ARG2 or H160F.
Moreover , simultaneous pointing-speech combinations in the available condition at @number@ months positively correlated with lexical and grammatical development at @number@ months of age.
Moreover , since late @number@ the Nursing Department no longer allows this practice for legal reasons.
Moreover , siRNA-mediated suppression of BiP and IRE1α exacerbated free fatty acid-bound albumin-induced apoptosis in cultured PTCs , whereas siRNA-mediated CHOP suppression ameliorated apoptosis.
Moreover , SIRT1 contributes to chromosomal condensation by mediating chromosomal loading of histone H1 and the condensin I complex.
Moreover , SIRT1 iKO mice with defective gut microbiota developed more severe colitis than control mice.
Moreover , Sirt1-induced autophagy protected against the PrP ( 106-126 ) -mediated decrease in the mitochondrial membrane potential value.
Moreover , SIRT6 inhibition significantly reduced proliferation and increased senescence associated β-galactosidase ( SA-β-Gal ) -positive chondrocytes ; it also led to increased p16 levels.
Moreover , sirtuins themselves can control metabolism through their ability to consume NAD ( + ) .
Moreover , site-specific muscle loss at the abdomen , as evaluated by RAM , also may be a predictor of metabolic syndrome like SMI.
Moreover , six patients were referred for cognitive rehabilitation , which resulted in a @percent@ success rate in set goals in the five evaluable patients.
Moreover , SkQ1 is effective in the therapy of various age-related diseases.
Moreover , SLC38A9 enables mTORC1 activation by cholesterol independently from its arginine-sensing function.
Moreover , sleep deprivation attenuated the systolic blood pressure orthostatic response in both age groups.
Moreover , sleeping disorders increase caregivers ' distress and may lead to hospitalization.
Moreover , snake fear was associated with increased vulnerability to illusory correlations in older adults.
Moreover , SNM1A recruitment was significantly reduced in CSB-deficient cells , suggesting coordination between the two proteins in vivo.
Moreover , somatic co-morbidities associated with aging are known to be risk factors for both insomnia and depression.
Moreover , some elderly are imprisoned with a concomitant cognitive impairment or psychiatric disorder while others will develop such diseases once incarcerated.
Moreover , some family-based designs are robust to confounding due to population admixture or substructure.
Moreover , some of them play a specific role in the replication of the damaged DNA templates.
Moreover , some other alterations of this most popular state of the art hair restoration technique have been mentioned briefly.
Moreover , some research-grade wearables also fail to provide transparent functionality due to limitations in proprietary software.
Moreover , specific changes in BPS were associated with a rapid deterioration of the global cognitive level in MCI patients.
Moreover , spironolactone significantly increased klotho and CYP27B1 protein levels in HEK293 cells ( @number@ hours ) .
Moreover , sputum production and voluntary saliva swallowing were strongly associated with oral intake status.
Moreover , SRT1720 does not increase mitochondrial function or improve glucose tolerance in AMPKα2 knockout mice.
Moreover , strength training enables to decrease the proportion of fibers containing MHC of hybrid form in the process of evolution.
Moreover , stroke participants showed the largest force control deficits during the grip release phase compared to age-matched and young healthy controls.
Moreover , strong cytoplasmic p53 localization is correlated clinically with elevated G3BP2 expression and predicts poor prognosis and disease progression to the hormone-refractory state.
Moreover , stronger fronto-cingulate connectivity was related to higher levels of adaptive rumination.
Moreover , studies are required to explore some inconclusive findings concerning sarcopenia in the older population.
Moreover , studies are sparse throughout the entire older age spectrum , from @number@ to @number@ years.
Moreover , studies have shown positive effects of DHEA administration on several of these disorders , with a satisfying safety profile.
Moreover , studies in mouse models of Alzheimer's disease suggest that certain classes of AEDs that reduce network hyperexcitability have disease-modifying properties.
Moreover , studies use a variety of different methods for data analysis , mainly based on model-free measurements and on the Patlak and Tofts models.
Moreover , studies with extended follow-up periods are needed to capture late relapses and possible differences in QALYs.
Moreover , study has shown that the testosterone / estradiol ratio has more influence over sexuality than does estradiol alone.
Moreover , Study @number@ showed that this beneficial effect on change in positive affect mediated the experience of fewer cold symptoms over time.
Moreover , subcutaneous injection of mice with DCPP1-overexpressing CHO cells increased tumor sizes.
Moreover , subjects over @number@ years old evidenced a significant decrease in categorization accuracy when objects were seen in incongruent contexts.
Moreover , substantial differences seem to exist between the neurogenic niche of the LV between rodents and humans.
Moreover , successful review of MOC requires collaboration and commitment by all stakeholders.
Moreover , suPAR may be an important mediator between organ dysfunction and physical performance.
Moreover , suppression of Casp12 significantly inhibited the basal activity of NF-κB and decreased the PMA-induced NF-κB reporter activity.
Moreover , synaptic dysfunction and learning deficits precede Aβ plaque deposition , suggesting that synaptic alterations may underlie the initial development of the disease.
Moreover , systemic administration of sodium salicylate , an FDA-approved NF-κB inhibitor , decreased inflammatory gene expression and improved repair in aged muscle.
Moreover , T1 was found to be significantly increased by @number@ % ( p < @number@ ) in AD patients compared to healthy subjects.
Moreover , tactile sensations were associated with specific colours ( e.g. , softness with pink ) .
Moreover , Tat + Nef had cumulative effects.
Moreover , tau deposits in the temporal lobe and distributed heteromodal areas were tightly nested.
Moreover , TCF7L2-rs7903146 is one of the most influential variants in T2D-genetic risk scores ( GRS ) .
Moreover TCI-140 is a useful inventory for the evaluation of the principal dimensions of temperament and character.
Moreover , tendons sonographic abnormalities were more frequently observed in diabetics.
Moreover , TE up-regulated the expression of Bcl-2 and down-regulated the expressions of Bax in the hippocampus of aged PS2 mutant mice.
Moreover , the abundance of these cells correlates with decreased vaccine responsiveness , early mortality in the very old , and accelerated HIV disease progression.
Moreover , the acceptive degree of this noninvasive method makes it potentially promising for future screening of prostate cancer.
Moreover , the age-related increase in pentosidine levels was more pronounced in patients with asthma.
Moreover , the aging of the population and the increasing life expectancy make the prediction of falls more and more important.
Moreover , the aging of the population and the increasing occurrence of glioblastoma beyond @number@ years of age are additional explanations.
Moreover , the analyses based on short data segments ( two minutes ) render the method practical for a primary care setting.
Moreover , the angiogenic effect of GM1-treated macrophages was diminished by RS102895 , an MCP-1 receptor ( CCR2 ) antagonist.
Moreover , the anticancer effects of Cimicifuga have been reported , but the underlying mechanism causing cancer cell death has been poorly described.
Moreover , the association between each sleep variable and CIND was measured by odds ratios based on logistic regression.
Moreover , the association between medical burden and lower life satisfaction was significantly stronger for insecure than for secure participants.
Moreover , the association could not be explained by health behaviors and medical conditions assessed in this study , nor by type of trauma exposure.
Moreover , the association remains significant after excluding patients and controls free from prevalent cardiovascular disease.
Moreover , the association was further demonstrated in logistic regression analysis ( rs17070145 : p = @number@ OR = @number@ ) .
Moreover , the Aβ1-42-containing AEL vesicles share properties with AD-like extracellular plaques.
Moreover , the background mortality may be approaching a lower limit.
Moreover , the basic clock properties of these peripheral cells closely mimic those measured physiologically and behaviorally in human and do not change during aging.
Moreover , the bias favouring general activities was amplified with regard to older adults as compared to younger adults.
Moreover , the causality issue remains unresolved.
Moreover , the cell loss potentially induced by mitochondrial dysfunction could explain the decline in adrenal hormonal and steroidal secretion during aging.
Moreover , the changes in plasma Klotho concentration and arterial stiffness were found to be correlated.
Moreover , the clinical evaluation evidenced significant improvements in ' skin elasticity ' compared to placebo.
Moreover , the combined effect with resistance exercise was studied by using a unilateral resistance exercise protocol.
Moreover , the composite network type variable stands out in capturing the differences in mental state.
Moreover , the contribution of the individual genetic background on the frailty status is still questioned.
Moreover , the criteria for establishing benefit or side effects of treatment strategies in this population are uncertain and not well recognized.
Moreover , the CS-induced loss of SRB1 induced an alteration of sebocytes lipid content , also demonstrated by cholesterol quantification in SRB1 siRNA experiments.
Moreover , the curative efficacy of Heshouwuyin after @number@ days was better than that of Heshouwuyin after @number@ days and the Shouwu pill group.
Moreover , the current findings show that mental imagery is lowered in a-MCI and AD and is likely related to the early semantic impairment.
Moreover , the decreased regional efficiency of the parahippocampal gyrus was correlated with impaired memory performances in patients.
Moreover , the decrease was observed for each NPI subscores.
Moreover , the degree of chaperone decline corresponds with the severity of neurodegeneration.
Moreover , the developments of new emerging conditions ( e.g. non-alcoholic steatohepatitis ) and novel therapeutic approaches have provoked increasing enthusiasm among hepatologists.
Moreover , the difference is more pronounced in patients treated with RAS inhibitors.
Moreover , the drug therapy taken by each patient was carefully reviewed.
Moreover , the early frontal old / new effect was positively correlated with associative discrimination accuracy.
Moreover , the effect of BBR on survival time extension and plasma redox regulation in endotoxin-shocked mice was largely weakened when Nrf2-depleted.
Moreover , the effect of Nox5 knockdown on PC-3 cell proliferation could be mimicked by pharmacological inhibition of JNK.
Moreover , the effect of using voxel- versus MIRD-type models on the calculation of the effective dose was also studied.
Moreover , the effects triggered by developmental environmental cues can be transgenerationally transmitted , potentially affecting offspring health outcomes.
Moreover , the enzyme activity , including collagenase , matrixmelloproteinase-2 ( MMP-2 ) and tyrosinase , were also evaluated.
Moreover the enzyme activity presents an opposite trend compared to that obtained in the analysis of the transcript and proteins.
Moreover , the EVD-based segmentation was demonstrated to be comparable to other state-of-the-art methods on a publicly available dataset.
Moreover , the examination of heterogeneity within one culture and its influence on quality of life has been largely ignored.
Moreover , the executive impairment exhibits a strong positive tendency with age , comorbidity and mortality.
Moreover , the exposure of organotypic hippocampal cultures to the same compounds led to synaptic impairment with decreased levels of syntaxin and synaptophysin.
Moreover , the expression of anti-aging / senescence SIRT1 was reported to decline along with aging.
Moreover , the expression of hyaluronan and its surface receptor CD44 drastically decreased as observed during chronological skin aging.
Moreover , the extent of NCX3 proteolysis correlated significantly with amounts of Aβ1-42.
Moreover , the findings have potential implications for resident care planning , facility programming , social policy development , and future research.
Moreover , the findings suggest that a decline of some forms of cross-modality may take place over a much longer time span than previously assumed.
Moreover , the fly model presents opportunities for innovative studies that cannot currently be pursued in the mammalian heart because of technical limitations.
Moreover , the formula was validated on pig tissues of different ages.
Moreover , the four groups of DEGs were associated with different TFs and localization patterns of their predominant types of H3K4me3 , H3K9me3 and H3K27me3.
Moreover , the four-hub network was found to cross-talk with both p53 and EGFR pathways.
Moreover , the frequency of the CD4 + NKG2D + subset was clearly related to the status of the T cells.
Moreover , the functional correlates of normative individual differences in older-adult value-based decision making remain unclear.
Moreover , the genetic correlations with fitness were almost identical in men and women.
Moreover , the glaucomatous cultures failed to activate autophagy when exposed to hyperoxic conditions.
Moreover , the high prevalence of these conditions among older persons makes them particularly amenable to targeting for preventive interventions.
Moreover , the hybrid material could work as a protein filter for @number@ month , which is six times the lifetime of polysulfone.
Moreover , the identification of specific lipid species in aging diseases and longevity would aid to clarify how these lipids alter health and influence longevity.
Moreover , the IL-15-inducible molecules Bcl-x ( L ) , MIP-1α , MIP-1β , and CCR5 were upregulated in the human BM.
Moreover , the impact of muscle strength training on cognitive function and brain structure remains speculative.
Moreover , the improved blood lipid profiles suggest additional health benefits associated to the intake of the olive polyphenol extract.
Moreover , the improvement in erectile function was well maintained , even after the cessation of treatment.
Moreover , the increased ReHo index observed in the postcentral and paracentral lobes might indicate compensation for the cognitive function losses in individuals with MCI.
Moreover , the increase in alcohol use during the period was fully explained by cohort replacement.
Moreover , the individual's health and well-being as well as attitudinal and motivational aspects are included in the definition as well.
Moreover , the influence of lifestyle factors such as habitual exercise on endothelial cell ( EC ) senescence is unknown.
Moreover , the interplay between IKK / NF-κB and RIPK1 signaling was recognized as a critical determinant of tissue homeostasis and inflammation.
Moreover , their generation continues nearly to the end of pregnancy , which may predispose premature infants to neurobehavioral disorders.
Moreover , their heart rate was assessed during the shift and in a reference period.
Moreover , their identity changes as adult children , deceased loved ones and God become more prominent.
Moreover , their interaction was significant ( β = @number@ p < @number@ ) .
Moreover , their perceived and real weight-bearing distribution showed good agreement ( ICC > or = @number@ ) .
Moreover , their safety profile has been evaluated in different settings in the elderly , assisting in minimizing risks related to their use.
Moreover , the Japanese government intends to promote family pharmacies ( pharmacists ) that not only prepare drugs but also give advice on health issues.
Moreover , the kinase CaMKII has been characterized as an important regulator of heart function and an arrhythmogenic molecule that participate in Ca2 + handling.
Moreover , the level of SA-β-Gal staining , an aging marker , is reduced by scopoletin.
Moreover , the levels of Mdm2 and caspase-3 expression were reduced in the cells exposed to spermine compared to blank group.
Moreover , the levels of SNO-parkin and p53 were simultaneously elevated in postmortem human PD brain compared to controls.
Moreover , the Luc activities correlated well with the disease severity.
Moreover , the mean NhTERT mRNA in subgroup with HBeAg loss was significantly higher than that in subgroup without.
Moreover , the mechanism also appears to be evolutionary conserved in both mammalian models , further corroborating the DevAge molecular model.
Moreover , the mechanism by which this response was achieved was different between the two groups.
Moreover , the number of axonal boutons that synapse with multiple spines is significantly reduced in the transgenic mice.
Moreover , the number of individuals with PML due to rituximab treatment is increasing ( over @number@ cases ) .
Moreover , the occurrence of the metabolic syndrome was significantly lower in those with higher NEPA levels in non-exercising and regularly exercising individuals.
Moreover , the older adults exhibited weakened resting-state functional connectivity between the supplementary motor area and left anterior insular cortex.
Moreover , the only statistically significant correlation with estradiol blood concentration on hCG administration day was found with one-axis dimensional variation.
Moreover , the optimum training load required to obtain a beneficial adaptation profile is lacking.
Moreover , the origin of cellular senescence in the skin is still unknown , and multiple origins are possible.
Moreover , the outcomes of PMBR in older women are similar to those seen in younger women.
Moreover , the overall functional performance and physical activity scores were similar in men and women.
Moreover , the overexpression of Pin1 is correlated with Rb hyperphosphorylation in breast cancer biopsies.
Moreover , the P2 waves showed differential patterns of domain-specific adaptation when location and identity was repeated among young adults.
Moreover , the pathogenesis of age-associated diseases such as epithelial skin cancer and neurodegenerative diseases has been partly attributed to the lack of hormones.
Moreover , the pathology data suggests a course initiated by tauopathy contradicting the contemporary clinical view of an Aβ initiated cascade.
Moreover , the percentage of Th17 cells and the serum IL-6 levels were higher in elderly healthy controls than those in young healthy controls.
Moreover , the policies are influenced by the policy-makers ' perceptions and path-dependencies , meaning policies and institutions that were introduced in the past.
Moreover , the premature ageing described in PLWH and the development of cancer share many molecular features.
Moreover , the presence of a concurrent stream increased the MMN peak latency of the older group but not that of the younger group.
Moreover , the presence of CMHs is an independent risk factor for subsequent larger intracerebral hemorrhages.
Moreover , the proper use of MSCs for clinical application requires a general understanding of the MSC aging process.
Moreover , the ratio changes in men versus women may have distinct pathological responses.
Moreover , there are increasingly more studies identifying and developing new biomarkers for OA.
Moreover , there are indications that the training response in the tendon is gender specific.
Moreover there is growing evidence that altered HPA activity is associated with various age-related pathologies.
Moreover there is no cure for dementia.
Moreover , the relationship between altered functional connectivity and age-related declines in bimanual coordination remains unclear.
Moreover , the relationships have some differences for the seniors with different sociodemographic characteristics and living in different residential areas.
Moreover , the results of clinical studies have shown that the antiplatelet drug aspirin reduces the incidence of vascular events and colorectal cancer.
Moreover , there was an interaction between number of teeth and age on severe cognitive impairment.
Moreover , there was a significant difference between Katz ADLs in the elderly before and after the intervention ( P < @number@ ) .
Moreover , there was a synergistic interaction between obesity and hepatitis virus infection.
Moreover , there was a tendency towards a higher collagen protein FSR and a smaller collagen fibril diameter in ACRO patients relative to GHD patients.
Moreover , there was no difference in the magnitude of insight occurrence following sleep and daytime -consolidation in aged participants.
Moreover , there was no significant difference ( P = @number@ ) between the combination of both ethnic groups and controls.
Moreover , there were graduated changes in the type and number of symptoms associated with GAD in each successive age group.
Moreover , there were only a few studies conducted in an Asian population.
Moreover , there were significantly more eyes with lower minimum VA scores in the older age groups ( p < @number@ ) .
Moreover , the rise of proteomics has allowed the identification of the specific proteins targeted by protein carbonylation.
Moreover , the risk factors for AD and VaD differed for urban and rural populations.
Moreover , the risk of IgAN progression to ESRD of the older patients in Asia was higher than that of the older patients in Europe.
Moreover , the risk was @number@.60-1.76 times higher among those with both auditory and visual impairments than the risk for those without any impairment.
Moreover , the role of miR-200c on ROS modulation was also investigated.
Moreover , the RPE of older mice demonstrated impaired induction of the protective Nrf2 pathway following oxidative stress induced with sodium iodate.
Moreover , the RR ( @number@ ) of the Asian countries was much higher than the RR ( @number@ ) of the European countries.
Moreover , the SC rehydration capacity is significantly lower in sun-exposed aged females than in age-matched males.
Moreover , these acetylation levels in SIRT1-depleted cells were significantly higher than those in control cells during cellular senescence.
Moreover , these beliefs differed across emotion categories.
Moreover , these cellular phenotypes were accompanied by an up-regulation of TXNIP and TP53 transcriptional expression.
Moreover , these changes were able to be recovered when the exogenous RANKL was added to the MSC-CM culture.
Moreover , these compounds demonstrated cellular activity by inducing sister chromatid exchanges , a hallmark of Bloom syndrome.
Moreover , these effects were successfully maintained over the @number@ months of the trial.
Moreover , these findings are specific to WM networks and cannot be explained by other surrogates of global WM integrity.
Moreover , these findings establish baseline national estimates as researchers continue to track growth and changes in the residential care industry.
Moreover , these findings suggest that NAM can reduce cellular deterioration caused by oxidative damage in postmitotic cells in vivo.
Moreover , these functional data were paralleled by an up-regulation of mitochondrial DNA.
Moreover , these functions were mediated by targeting DNMT1.
Moreover , these isoforms were associated with rs688 , an exon @number@ polymorphism that was associated with LDL-cholesterol and Alzheimer's disease risk.
Moreover , the sensing of AGEs by the host cells may constitute a warning system for the presence of bacteria.
Moreover , these parameters were plotted with TUG test duration.
Moreover , these policies generally are not designed to encourage continuing work rather than premature retirement.
Moreover , these programs are valuable interventions in other frailty domains , such as falls and cognitive decline.
Moreover , these regional alterations vary not only through time , but across human populations and the sexes.
Moreover , these results suggest that robotic systems can provide a new and effective approach in the assessment of sensorimotor function.
Moreover , the serum IGF-1 level was correlated with muscle size.
Moreover , these studies may produce the first evidences about the novel concept of ' cognitive frailty ' and its potential for reversibility.
Moreover , these variants have potential as diagnostic markers for individuals at a high risk of developing presbycusis.
Moreover , the severe LB pathology suggests that dysfunction of the PLA2G6 gene primarily contributes to LB formation.
Moreover , the shear wave velocities at the inner and outer glands all correlated significantly with age.
Moreover , the SIRT1 inhibitor niacinamide could reverse SIRT1's protective effect in cultured neonatal rat cardiomyocytes.
Moreover , the SIRT1-mediated inhibition of PAI-1 expression exerted an antisenescence effect in HUVECs.
Moreover , the size of the EBA was smaller in children with ASD than in TD children.
Moreover , the small-world organization undergoes continuous changes during normal development and ageing and exhibits dramatic alterations in neurological and psychiatric disorders.
Moreover , the social support provided by family members and the advantages of the Mediterranean dietary habits are declining.
Moreover , the statistically significant decrease in the protein content within neuron bodies was observed.
Moreover , the ST group was randomized to TT ( n = @number@ ) or placebo ( n = @number@ ) after @number@ weeks.
Moreover , the strategy for prolonged nasotracheal safe extubation was carefully described.
Moreover , the studies are not homogenous.
Moreover , the studies had to include an exercise or physical activity protocol in the intervention.
Moreover , the subjects with a high WBV had a higher prevalence of SCI.
Moreover , the terms falls efficacy and fear of falling are often used interchangeably in the literature , which is conceptually problematic.
Moreover , the thresholds of pitch contour discrimination were significantly higher for older listeners than for younger listeners.
Moreover , the translation error in the EGGs of the elderly individuals increased during hot stupe heating.
Moreover , the variance was the smallest in the bimodal condition.
Moreover , the vegetable peptones activated p90 ribosomal s6 kinase , which was mediated by activating the Raf-p44 / 42 mitogen-activated protein kinase signaling pathway.
Moreover , the ventral anterior insula is required for both processes.
Moreover , they are less able to activate frontal theta generators during attentional tasks compared with younger persons.
Moreover , they caused inhibition and aging of at least @percent@ of the activity of NTE at sub-lethal concentrations.
Moreover , they demonstrate the feasibility of tracking uptake patterns in near real-time even with simple summary counts of medical claims data.
Moreover , the yellow filter globally improved the speed of categorization for the elderly participants.
Moreover , they have not affected death from other age-related diseases.
Moreover , they possess confidence in economic institutions and are more likely to feel economically secure.
Moreover , they should maintain their vital force and avoid any activities that tax the body.
Moreover , this adaptation showed a clear decline with advancing age , but only for peripheral auditory space ( beyond ±10° from midline ) .
Moreover , this association also largely accounts for the effect of disturbed sleep on these psychiatric disorders.
Moreover , this association did not replicate in Tremor-dominant PD patients from New-York.
Moreover , this EIG frequency band correlated with anxiety scores along with resting-state functional connectivity between the insula and dorsal anterior cingulate cortex.
Moreover , this freezing increased with the number of footshocks given to the subject and it was accentuated within seconds after footshock delivery.
Moreover this insight opens up new opportunities for chemointervention and chemoprevention for this important clinicopathological progression.
Moreover , this in vivo maturation allowed patient-derived PSC-CMs to reveal the disease phenotype of arrhythmogenic right ventricular cardiomyopathy , which manifests predominantly in adults.
Moreover , this is the first study reporting the likely existence of a founder effect for C157KfsX97 mutation in Southern Italy.
Moreover , this is the population at greatest risk of morbidity and mortality with any given complication.
Moreover , this may be caused by hypoxia rather than by hypobaria.
Moreover , this mechanism may be relevant for understanding memory muddles in aging and pathological states.
Moreover , this negative health selection into naturalization becomes stronger for those naturalizing after the @number@ Welfare Reform Act.
Moreover , this outcome was confined to concept-shifting performance and was especially observable between 6- and 12-year follow-ups.
Moreover , this phytocompound partly reduced gene expression of NF-κB p65 ( by @percent@ , p < 0.05 ) .
Moreover , this relationship between diabetes , function , and cost was age-dependent , increasing as people get older.
Moreover , this response dropped during the intervening low transmission / dry season , suggesting it is sensitive enough to detect variation in vector density.
Moreover , this review highlights important sex-dependent differences in the adaptation to developmental insults.
Moreover , this review suggests new research directions to improve our understanding of the vulnerability of the pubertal period to immunological stressors.
Moreover , this study presents the exacerbation of envy and Schadenfreude as a new potential hallmark of bvFTD that could impact in diagnosis and progression.
Moreover , this underscores the importance of recruiting more donor axons in attempting to improve facial reanimation in the older patient.
Moreover , this work provides an excellent example of how such efforts can begin to inform effective planning and service provision.
Moreover , thorough chewing significantly reduced postprandial ratings on palatability of the test food.
Moreover , those properties and associations among them may be modified by age-associated increase in vascular risk.
Moreover , those who slept ≥9 h were more likely to report daytime sleepiness ( OR @number@ @percent@ CI @number@ @date@ ) .
Moreover , three combinations ( A , B , and C ) of nutrients applied in this study effectively reversed D-gal-induced muscular impairment.
Moreover , through anti-inflammatory effects and antioxidant properties , the resveratrol is believed to protect organ function in trauma-hemorrhagic injury.
Moreover , through complementary behavioral analysis , torsinA was able to restore normal neuronal function in mutant G85R SOD1 animals.
Moreover , TP53INP2 gain of function enhances muscle wasting in a highly catabolic context such as in streptozotocin-induced diabetes.
Moreover , TRAIL / Gln deprivation upregulated the apoptotic sub-G OBJECTIVES : Autophagy constitutes a defense mechanism to overcome aging and apoptosis in osteoarthritic cartilage.
Moreover , treatment of HSCs with exogenous Pot1a inhibits the production of reactive oxygen species , suggesting a non-telomeric role for Pot1a in HSC maintenance.
Moreover , treatment of PDAPP transgenic mice with the known TrkA inhibitor GW441756 increased sAβPPα and the sAβPPα to Aβ ratio.
Moreover , trends and perspectives for future investigation of this plant are discussed.
Moreover , triple-knockout mice lacking synucleins developed age-dependent neurological impairments , exhibited decreased SNARE-complex assembly , and died prematurely.
Moreover , TRX80 exerts a powerful angiogenic effect in both in vitro and in vivo mouse studies.
Moreover , understanding human energy metabolism through sirtuins may provide a novel approach to exercise physiology.
Moreover under traditional conditions , most human males undergo reproductive cessation at the same time as their wives.
Moreover , unlike bona fide CR , resveratrol has not been shown to extend lifespan in lean mice.
Moreover , UVB-RHE release more interleukin-1α and @number@ into the culture medium and present altered differentiation with a thinner stratum corneum compared to normal RHE.
Moreover , viewing incapacitated older adults led to increased concern toward them and perceived efficacy in helping them.
Moreover , waves of novel therapies ways for ovarian carcinoma based on the functions of autophagy were collected.
Moreover , we aimed to describe cerebral ageing effects on MTI parameters in an elderly cohort.
Moreover , we aimed to discuss and identify the possible role of SGK-1 as possible molecular target to counteract and prevent aging.
Moreover , we also investigate the patterns of this relation between different European countries.
Moreover , we analyze the impact of the activity of the involved epigenetic modifiers on these changes.
Moreover , we compared brain and plasma levels of the compounds after administration to mice.
Moreover , we conclude that , within the cognitive reserve framework , education does not have significant protective power against age-related cognitive decline.
Moreover , we confirmed that 15d-PGJ₂ suppressed the growth of HEK293 cells.
Moreover , we confirmed that PYP1-5 increased type @number@ collagen expression using enzyme-linked immunosorbent assay ( ELISA ) , western blot analysis and quantitative PCR.
Moreover , we confirm the previously described associations with APOE and LPA.
Moreover , we consider the Jensen-Shannon distance between sample-specific energy landscapes as a measure of epigenetic dissimilarity and demonstrate its effectiveness for discerning epigenetic differences.
Moreover , we demonstrated a link between casein kinase @number@ ( CK2 ) and RBC shrinkage via regulation of the Gardos channel activity.
Moreover , we demonstrated that microglia-like cells could be induced from human monocytes by coculture with astrocytes.
Moreover , we demonstrate significant differences in the activity of neurogenesis in the adult marmoset brain compared to the adult mouse brain.
Moreover , we demonstrate that the loss of endogenous TRIAD3A in the mouse hippocampal CA1 region led to deficits in spatial learning and memory.
Moreover , we detected an increased frequency of γ-H2A.X-positive cells in aged rat gingival tissues.
Moreover , we detect SNO-PTEN in human brains with sporadic PD.
Moreover , we discovered the SNP rs6214 on the IGF1 gene would significantly affect the serum IGF-1 level.
Moreover , we discuss how these changes may affect or predict response to vaccination in immune compromised individuals.
Moreover , we discuss the overlap in major underlying pathologies of dementia derived from their genetic associations.
Moreover , we discuss various numerical and simulation approaches used to study the BBB , and possible future directions based on multi-scale methods.
Moreover , we examined whether a significant correlation between magnesium parameters and clinical outcome existed.
Moreover , we explain other ideas to overcome the lack of systematization within the set of analysis methods suitable for HET.
Moreover , we find that UDL particularly affects marital stability in the presence of children.
Moreover , we found GMPS transcriptionally repressed in a p21-dependent manner and its repression maintained in the context of p53-mediated cellular senescence.
Moreover , we found that association between genetic variability in the pro-antioxidant pathway and functional status at old age is influenced by sex.
Moreover , we found that Aβ treatments can reduce both CUTA and copper levels in mouse primary neurons.
Moreover , we have also reported the crystal structures of AdipoRs.
Moreover , we highlight that these conclusions need to be supported by other studies with different cohorts and a larger population scale.
Moreover , we highlight the complexity of targeting microglia for therapeutic intervention in neurodegenerative diseases.
Moreover , we identified a common hTERT haplotype that is associated with both exceptional longevity and longer telomere length.
Moreover , we investigated associations of LLACs with age , time on dialysis , type-2 diabetes mellitus , history of stroke , and myocardial infarction.
Moreover , we investigated the influence of disease-related factors on daily physical activities in PD patients.
Moreover , we investigate the factors that affect each item in the questionnaire.
Moreover , we made the coefficients correlation for differences in muscular force versus the Rivermead Motor Assessment ( RMA ) arm section.
Moreover , we offer a perspective on how to integrate the novel targeted agents for CLL therapy into sequential treatment approaches.
Moreover , we propose that , in contrast to emerin , nesprin-2 is a positive regulator of the Wnt signaling pathway.
Moreover , we quantified levels of cellular senescence by senescence-associated β galactosidase ( SA-βgal ) assay.
Moreover , we reported a correlation between APE1 and NPM1 expression levels in ovarian cancer , with NPM1 overexpression being a marker of poor prognosis.
Moreover , we revealed that the down regulation of the GJA3 gene was associated with H2O2-induced lens epithelial cells apoptosis.
Moreover , we review the literature in order to provide pharmacological treatment strategies for stroke patients at high risk of suicide.
Moreover , we showed increased expression of Cryab in cytoplasmic inclusions in a subset of glial cells in Parkinsonian brain.
Moreover , we show that in the presence of these AGEs there is an upshift of pro-inflammatory cytokins by mammalian cells.
Moreover , we show that parameters VMS , P1 , and P2 positively correlate with age , contrary to negatively associated H parameter.
Moreover , we show that the HPV E7 protein level differs considerably between individual cells in cultures of several established cervical cancer cell lines.
Moreover , we show that the inhibitory effects are reversible.
Moreover , we show that the recovery of the organelle integrity recruits active Akt translocation to the mitochondrion.
Moreover , we show that the rescue of Purkinje cell dendrites and dendritic spines by HMGB1 could be downstream effects.
Moreover , we show that these low dimensional representations favorably compare to descriptions obtained with more commonly used matrix factorization methods like PCA and ICA.
Moreover , we studied the neuroprotective effects of baicalin by using a rat model of middle cerebral artery occlusion in vivo.
Moreover , we suggest that initial longer TL could be a potential predictor for a better weight loss response.
Moreover , we used both the p38 inhibitor ( SB203580 ) and GSN siRNA to confirm our conjecture.
Moreover , we verified extrachromosomal ribosomal DNA circles production and histone hyperacetylation levels , typical marks of sir2Δ strains.
Moreover , we wanted to compare the fibre type composition of the left and right muscle.
Moreover , we wanted to know whether and at what level it was possible to induce a similar impairment in younger listeners.
Moreover , we will discuss how the amount or composition of each nutritional component may influence longevity or health in humans.
Moreover we will list all the observational and intervention studies conducted in humans.
Moreover , when accounting for global gray matter volume reduction , the age-cloze correlation in the left MFG and right IFG was absent.
Moreover , when compared with the nondialysis day , these patients exhibited worse dietary quality , on the day of dialysis.
Moreover , widows and widowers tend to retire prematurely in Germany , whereas no such effect could be found in Spain.
Moreover , with aging higher inflammation in adipose tissue may be observed and may contribute to inflammaging.
Moreover , with aging of the population and the high incidence of diabetes , hypertension and obesity , this trend may prevail.
Moreover , with careful and strategic planning , shared resources can be developed that will enable exponential advances in the field.
Moreover , with changing demographics , arrhythmias increasingly afflict the aging and growing population of survivors with congenital heart disease.
Moreover , with continual introduction of new clinical features , the need to repeat the feature selection task can be very time consuming.
Moreover , within the already vulnerable nursing home population are many people who are receiving palliative end-of-life services when a disaster strikes.
Moreover , women had significantly higher scores than men.
Moreover , women tend to wake up earlier than men and exhibit a greater preference for morning activities than men.
Moreover , wounds in the oral cavity heal under very special environmental conditions compared with skin wounds.
Moreover , WRN depletion in HL60 cells led to the hyper-activation of homologous recombination repair via up-regulation of RAD51 and BLM protein levels.
Moreover , xenograft model treated with either Klotho overexpression vector or recombinant human Klotho administration presented restrained tumor growth and lower Ki67 staining.
Moreover , yeast offers several methodological advantages allowing a rapid and relatively easy way of establishing gene-protein-function associations.
Moreover , young individuals also demonstrated a better ability to degrade damaged proteins by up-regulating the expression of chaperones and improving proteasome activity.
Moreover , young people used more elastic energy than older people.
Moreover , young PINK1-deficient mice developed similarly dysmorphic , dysfunctional mitochondria in the AECIIs and were vulnerable to apoptosis and development of lung fibrosis.
Moreover , α-tocopherol concentration was selectively lower in the aged exercise group , compared to the young exercise at baseline.
More participants developed adverse events after treatment with HBTX-A doses , than with the placebo ( p < @number@ ) .
More participants with normal sensory acuity passed the MoCA compared to those with sensory loss , even after modifying scores to adjust for sensory factors.
More patients followed strictly Mediterranean diet and consumed healthy foods more frequently.
More patients in the non-HR group experienced hip surgery than in the HR group ( @number@ vs. @percent@ , P < @number@ ) .
More patients who underwent surgery after @number@ h from the onset of symptoms required an intestinal resection.
More patients with dementia or delirium were given PNB.
More people are living with HIV into midlife and older age.
More people now die of age-related diseases than ever before , but these diseases have been resistant to elimination.
More photo-specific mutations might be CC to TT tandem transitions which arise from UV-induced cyclobutane pyrimidine dimers.
More plaques were found in cervical than other spinal levels at all time points examined.
More positive views of work were predictive of wanting to continue working as was having nontraditional gender-role attitudes.
More practical models could also be used as a more suitable tool in gerontological field and clinical studies.
More precisely , a facilitatory effect of NOF was observed for the young adults , but not for the older ones.
More precisely , MMSE scores increased with education level and decreased with age.
More precisely , the femoral shaft is compressed between two ipsilateral implants with most of these fractures being located on the supracondylar femoral shaft.
More problem items and physical-practical problems were selected by individuals who reached clinical levels of depression.
More profound data should improve the basis for decisions in health and education politics.
More pronounced change suggests the development of dementia or mild cognitive impairment ( a precursor to dementia ) .
More quantitative studies are needed.
More rapid rebalancing can save money , break even , or increase spending , depending on the pace and program specifics.
More recent GWAS also identified ANRIL as a risk locus for gliomas and basal cell carcinomas in accordance with the princeps observation.
More recently , another oil-in-water emulsion , AS03 , has been approved as a component of pre-pandemic H5N1 and pandemic H1N1 @number@ vaccines.
More recently , attention has been given to DNA hydroxymethylation ( 5-hydroxymethylcytosine [ 5hmC ] ) , the oxidized form of 5mC.
More recently , cardiac resynchronization therapy ( CRT ) has become another important therapeutic option for treating heart failure due to systolic dysfunction.
More recently , chair rise performance has been assessed in younger populations as a baseline for assessment of subsequent age-related declines in function and power.
More recently , homozygous missense mutations have been reported in @number@ families with early-onset parkinsonism and seizures.
More recently , hospice has diffused throughout state , federal , and municipal correctional systems.
More recently , next-generation sequencing-based methods have been developed to accurately determine the complete landscape of base substitution mutations in single cells.
More recently , novel classes of drugs were discovered which enhance cGMP production by targeting the NO receptor soluble guanylate cyclase ( sGC ) .
More recently , sarcopenia has been described in various forms of chronic disease , including patients with end-stage organ disease awaiting transplantation.
More recently , some new aspects emerged about the potential endogenous function of CYP2D6 in terms of behavior and brain disorders.
More recently stilbenoid compounds have shown promise in the treatment and prevention of neurodegenerative disorders , such as Huntington's , Parkinson's , and Alzheimer's diseases.
More recently , the clinical application of basic fibroblast growth factor was reported with encouraging outcomes.
More recently , the contribution of an altered nasal microbiome to the development of CRS has also been proposed.
More recently , the idea that chondrocyte aging is closely associated with the progression of cartilage degeneration has been promulgated.
More recently , the involvement of autophagy in various physiological functions has been investigated in multicellular organisms.
More recently , the selective action of capsaicin against cancer cells has been reported.
More recently , Tpr function has been linked to events including p53 signaling and premature aging in Hutchinson-Gilford Progeria Syndrome ( HGPS ) .
More recently variants in COQ2 have been linked to MSA in the Japanese population although this finding awaits replication.
More recent postmortem studies have helped localize the possible source of ET to structural alterations in the cerebellum and its connecting pathways.
More recent publications , systematic reviews , and meta-analyses were given preference.
More recent research has shown a trend toward incorporating stress management as a component of workplace wellness programs.
More recent studies have shown that there is a cost-benefit to glycemic control as well , through reduction of hospital stay and prevention of complications.
More recent studies revealed the molecular mechanisms how these transcription factors regulate bone and cartilage development.
More recent studies with samples at every decade have reported conflicting results.
More recent work has revealed the role of RAGE in inflammatory cell recruitment and extravasation of leukocytes across the endothelial barrier with further inflammatory events.
More recent work revealed that the Ant-induced DCD is suppressed by reduced cytosolic protein synthesis.
More research comparing different methods to measure gait in early stages of dementia under different dual task conditions is neccessary.
More research , however , is necessary to evaluate the effectiveness of this intervention.
More research in this area is needed , specifically , placebo-controlled randomized trials in both mid-life and late-life with cognitive dysfunction as a primary endpoint.
More research in this field is needed.
More research is clearly needed to fully unravel the importance of BCOs in tomato carotenoid metabolism and the consequence on human health and diseases.
More research is necessary to develop a short version of the ADAP that is easily applicable in the home environment of older adults.
More research is needed including controlled PK studies to address the clinical relevance of these observations , especially in the aging HIV-infected population.
More research is needed in order to study which determinants affect the process of an active and functional ageing.
More research is needed in this emerging area.
More research is needed on health consequences of caloric restriction and foods with caloric restriction-mimetic properties to identify possible nutritional interventions for healthy aging.
More research is needed that specifically focuses on the role of oncology nurse navigators in older populations.
More research is needed to assess effectiveness of antidepressant prescribing.
More research is needed to determine the optimal types and dosing of aerobic conditioning.
More research is needed to elucidate natural history and underlying pathomechanisms of the most common airway diseases , Asthma and COPD.
More research is needed to elucidate the link between T2D and dementia and identify strategies to maintain cognitive function among people with T2D.
More research is needed to elucidate the underlying mechanisms explaining these results.
More research is needed to elucidate why having baseline dyslipidemia relates to lower future HCC mortality.
More research is needed to explore the mechanism behind older people's desistance from , persistence in , and resumption of volunteer engagement.
More research is needed to have confidence that under- and overestimations of BA are indicators of aging variability at the level of the individual.
More research is needed to identify and validate additional triage criteria that are sensitive to severe injuries in older persons.
More research is needed to identify the exact causes of such disparities.
More research is needed to identify the most effective approaches to withdraw medications and predictors of outcomes.
More research is needed to improve our understanding of the genetic influences on aging and the relationship with age-related diseases.
More research is needed to investigate why older adults choose to adhere or not adhere to their treatment regimens taking into account their multimorbidity.
More research is needed to understand the causal mechanisms underlying these relations.
More research is needed to understand the physiologic basis underlying these sex differences.
More research is needed to understand the unique age trends prevalent in specific populations and tasks.
More research is needed to understand this relationship.
More research is needed to unpack population heterogeneity in the association between coping strategies and well-being.
More research is required to explore the mechanisms at work in the process of aging in persons with CP.
More research is warranted to elucidate whether use of ChEIs in clinical practice can reduce the need for psychotropic drugs in AD patients.
More research needs to be done to determine whether the slope of the LAEP recovery function is correlated with speech-perception performance.
More research with pharmacologic and psychosocial interventions is needed , however , to better understand how to treat this population of elderly patients.
More respondents in the elderly group were willing to follow the telephone-assisted instruction rather than performing CPR under their own initiative.
More rigorous , large scale research is needed in this area.
More rigorously designed and measured , randomized double-blind , placebo-controlled trials with larger sample size are needed to verify the current conclusions.
More rigorous studies incorporating age-specific adaptations are needed.
More samples per subject are needed for low-variability and unmethylated loci.
More selective changes in regional gray matter volume and cortical thickness were noted in parietal , medial temporal , and frontal areas.
More senior adults have hypertension as they age.
More senior CNAs , both in regard to age and tenure , reported greater preparedness levels.
More severe dementia and a poor prognosis were associated with less antibiotic use in various countries.
More severely affected patients may experience a more aggravated inflammatory response.
More significant growth was noted in younger patients ( P = 0.02 ) .
More significantly , they showed a longer time to peak force , particularly in the vertical direction during the preparation phase.
More skillful toddlers who could build high towers had a longer deceleration phase when placing blocks on the tower than toddlers who built low towers.
More social supervisor support as perceived by staff was found to predict less activity involvement.
More somatic health problems were associated with poor SRH in women.
More specifically , cataract patients ' optical systems transmit light poorly , especially the shorter wavelengths that affect the circadian system more.
More specifically , deformation analysis found HME had relatively more volume in the CA1 sub-region of the hippocampus ( p < @number@ ) .
More specifically , fine motor skill , processing speed and visuospatial ability , but not memory , are affected most by age.
More specifically , high levels of mutuality diminished role strain in caregivers of patients with mild dementia.
More specifically , hyperactivity in the hippocampus may be detrimental and could be one factor that drives Aβ deposition.
More specifically , older suicide attempters seem to neglect outcome probability and make poor choices.
More specifically , the combination of gender , age , and intellectual disability raises unique social issues.
More specifically , the locus affects the deposition of neuritic amyloid plaque ( p = @number@ ) .
More specifically , the progressive accumulation of variations in mtDNA of post-mitotic tissues represents a major contributing factor to both physiological and pathological phenotypes.
More specifically , using the traction provided by the service dog has physical benefits because MWC users can operate their MWCs with less effort.
More specifically , we concentrated on word-finding failures , which increase with age.
More specifically , we describe practical coordination processes.
More specifically , we provide an overview of studies showing adjustments during step preparation , initiation , unobstructed , and obstructed gait.
More studies addressing the relative efficacy , tolerability , and safety of psychotropic medications are needed.
More studies are needed to define a correlation of chemical exposure as a co-factor on the pathogenesis in some melanoma patients.
More studies are needed to describe the influences affecting weaning older adults from mechanical ventilation.
More studies are needed to determine optimal immunosuppression regimens for elderly individuals.
More studies are needed to determine the optimal time to test ORT in the large number of young survivors on combined estrogen and progesterone contraceptives.
More studies are needed to explain these sex-specific associations.
More studies are needed to further evaluate OSCAR and identify ways to improve its effectiveness.
More studies are needed to identify risk factors for ADL disability with a view to preventing it in time.
More studies are needed to investigate the predictive value of DL as a marker of cognitive decline , particularly executive functions.
More studies are required to further evaluate its psychometric properties , particularly in the areas of factor structure and responsiveness.
More studies are warranted to explain this significant decrease in FM.
More studies need to be performed to determine the optimal timing , intensity , and modality of RRT in the geriatric population.
More studies utilising a prospective design are needed to corroborate findings and more studies are needed with adults.
More studies with long-term follow-up periods and better randomization are needed to clarify whether en bloc strategies provide better long-term oncological survival.
More study is needed to determine if the association is causal , and if treatment efforts could reduce the risk of cognitive impairment and dementia.
More study is needed to determine whether HL contributes to dementia and whether treating HL can reduce the risk of dementia.
More survivors reported having @number@ or more chronic conditions compared to controls ( @percent@ vs. @percent@ , respectively ) .
More systematic , multidisciplinary approaches will further facilitate drug repositioning for AD.
More systematic research is needed.
More systematic research with special focus on the older population is needed to understand this age-related decline in prevalence rates.
More than 1·2 million patients are diagnosed with colorectal cancer every year , and more than @number@ die from the disease.
More than any other ethnic group , Filipino women are over-represented among health care aides in the Canadian health care system.
More than @date@ of women had had tuberculosis symptoms for more than half a year before tuberculosis was diagnosed.
More than half believed that a ' male climacteric ' was related to decreased libido and less strong erections.
More than half failed to respond at all.
More than half of companion communication behaviors were directed at improving doctor understanding of the patient.
More than half of geriatric patients have @number@ or more surgical procedures in their lifetimes.
More than half of home healthcare visits and around half of the professional home visits were provided by community home nursing care institutions.
More than half of respondents were whites ( @percent@ ) , and almost half were married ( @percent@ ) .
More than half of the elderly in today's society suffer from sleep disorders with detrimental effects on brain function , behavior , and social life.
More than half of the participants ( @percent@ ) were not engaged in health promoting physical activity.
More than half of the population was not identified to be at high risk by the FRAX® BMI ( body mass index ) .
More than half of the studies used data from administrative or clinical databases or chart reviews.
More than @number@ brain donations were accrued to date and have been subjected to comprehensive pathological assessment.
More than @number@ certified physicians were born so far.
More than @number@ compounds have been isolated ; among them prenyl-flavonoids are the major constituents and also important chemotaxonomic markers.
More than @number@ disease loci have been described with different modes of inheritance.
More than @number@ laboratory parameters were measured , and a biobank was set up.
More than @number@ million Americans provide care to a family member ; roughly two thirds are women providing care to aging mothers.
More than @number@ million workers have coronary heart disease ( CHD ) with significant work limitations and disability.
More than @number@ mutations in the gene encoding A-type lamins ( LMNA ) cause progeria , a rare premature aging disorder.
More than @number@ older pedestrian fall-related injuries each year involved a kerb.
More than @number@ paraffin-embedded blocks and @number@ histological slides have also been collected since @number@
More than @number@ patients and volunteers in Europe , Australia , and Asia have been investigated with these unique tomographs.
More than @number@ seniors attended the sessions and @number@ briefs were received from scientists and associations.
More than @number@ skin ageing scales exist , which makes it difficult to choose outcome measures and to compare study results.
More than @number@ tissue requests have been served and currently about @number@ are served annually.
More than @number@ whole-body donations have been received since this service was commenced in @number@
More than @number@ years after mTOR's discovery , a wealth of metabolic and ageing-related effects have been reported.
More than @number@ years later , these forecasts have been confirmed and new emerging problems call for further reflection.
More than one half ( @percent@ ) reported increased confidence in addressing driving.
More than one hundred probes were correlated to aging , nine of which belonged to the KEGG group map04080.
More than one third of the population under investigation was considered to be at high risk for malnutrition.
More than other portions of the population , the elderly are most commonly affected by chronic diseases such as Parkinson's disease.
More than @percent@ of elderly patients are suffering from malnutrition which is information that concerns.
More than @percent@ of HD participants had an extreme TMS phenotype for at least one visit.
More than @percent@ of HF patients have CKD and the close relationship between CKD and HF worsens their prognoses.
More than @percent@ of O2 produced during normal metabolism is generated by the electron transport chain in the inner mitochondrial membrane.
More than @percent@ of older adults had a sedentary lifestyle.
More than @percent@ of participants indicated they were the main decision maker on receiving radiation therapy.
More than @percent@ of patients did not receive any analgesic medication.
More than @percent@ of patients from the study group underwent previously pelvic surgery due to various reasons.
More than @percent@ of patients over @number@ years old suffer from one infirmity , and @percent@ suffer from two or more infirmities.
More than @percent@ of people younger than @number@ years had mild CTS.
More than @percent@ of study participants were still in the moderate to high cardiovascular risk range based on CRP values at year @number@
More than @percent@ of the leukocyte blood gene expression response was similar in male and female patients.
More than @percent@ of the study population had DF.
More than @percent@ reported significant emotional distress ( CES-D ≥ @number@ ) that warrants clinical attention.
More than @percent@ were white women with a mean age of @number@ years ( range , 24-65 years ) .
More than that , recent evidence has shown a highly possible interplay or dependence between stroke-induced neurogenesis and angiogenesis.
More treatment need seems to polarise into those elderly who are better educated as they retain more teeth into old age.
More treatment options are becoming available to women as research provides new information about the underlying pathophysiology of overactive bladder.
More unfavorable safety concerns attributing to the underlying liver disease severity and extra-hepatic presentations further compromised the treatment efficacy.
More units will be required over coming decades given rapid population aging.
More women than men and staff aged 50-59 had an increased need to reflect.
More women than men have strokes each year , in part because women live longer.
More work is needed to determine how assessment of control beliefs could enable targeting of clinical interventions to support at-risk older adults.
More years of education was associated with improved performance in all three cohorts.
More years spent disabled or unhealthy may result in greater burden on family members and greater dependence on public resources.
Morgentaler A , Polzer P , Althof S , et al.
Morisky self-reported scale was applied at baseline and at the end of the study.
Morlet wavelet transform ( MWT ) allowed documenting OPs time-amplitude-frequency distribution from raw traces.
Morning blood samples were analyzed for total and free testosterone , estradiol , and the AR CAG polymorphism.
Morning testing is also associated with brain activity similar to that of young adults.
Morphological analyses were performed by both light and transmission electron microscopy.
Morphological analysis of sandblasted alumina and hot chemical-etched zirconia surfaces were performed by scanning electron microscopy ( SEM ) .
Morphological changes in the gastric mucosal vessels were observed by hematoxylin and eosin ( HE ) staining and Verhoeff van Gieson ( EVG ) staining.
Morphological changes in the lips during ageing , including labial volume , area and thickness were assessed in healthy individuals.
Morphologically , dying ARPE-19 cells were extremely swollen and lost the integrity of their plasma membrane , positively detected with APOPercentage assay and PI staining.
Morphological similarities of the oligomers were confirmed by contact mode atomic force microscopy imaging.
Morphological studies of the oocyte and its associated cumulus corona cells provide only marginal value in the assessment of embryo developmental potential.
Morphometric age stratified patients at high and low risk for mortality.
Morphometric analysis was done by Vision Assistant software.
Morphometric analysis was performed by ImageJ.
Morphometric , conventional echocardiographic , tissue Doppler and strain analytic characteristics of transgenic mice and HCM patients were assessed.
Morphometric features were visualized as maps of local contractions and expansions , and significance was displayed as Student's t-test statistical maps.
Morphometric measurements were taken of the hepatic arteriole , the cross-sectional diameter , and its wall thickness.
Morphometric parameters extracted from theoretical cell areas computed programatically were also analysed.
Morphometric parameters , the indicators of carbohydrate and lipid metabolism , and the levels of hormones , including AMH , were studied.
Morphometry is quantified globally by the volumetric measurement and locally by the vertexwise surface areas.
Morphometry was performed on low-magnification electron microscope images using computer-assisted technology.
Mortality and modified Rankin Scale ( mRS ) were assessed at @number@ days.
Mortality and morbidity were associated with emergency surgery , wound classification and baseline comorbidities , but not surgical approach.
Mortality at Day @number@ was @percent@ ( 49 / 145 ) and attributable mortality was @percent@ ( 39 / 145 ) .
Mortality at discharge included @percent@ of the dementia group and @percent@ of controls ( P = @number@ ) .
Mortality at @number@ months was @percent@ among the oral feeding group and @percent@ among the alternative feeding group ( p = @number@ ) .
Mortality caused by acute cardiopulmonary disease is decreasing , and in many countries the population is aging rapidly.
Mortality cost per person is also predicted to decrease ( @date@ @number@ million yen depending on the model in @number@ ) .
Mortality data according to disease and life expectancy were retrieved from the Korean Statistical Information Service.
Mortality data from central sources.
Mortality data from trials with a supplementation period of at least one year were pooled.
Mortality data linkage and active search for participants were used as a follow-up strategies.
Mortality data , recorded until @date@ , @number@ were obtained from the municipal registry.
Mortality data were available up to @date@ .
Mortality data were collected from age 70-90.
Mortality data were documented after a mean follow-up period of @number@ years.
Mortality data were obtained from a state vital statistics department using date of birth and Social Security numbers.
Mortality data were recorded from the Israeli National Population Registry.
Mortality data were reviewed from hospital records , claims data , Social Security Death Index and interviews with Discharge Managers.
Mortality deceleration-the slowing of mortality's rise with age-has been considered an important window into heterogeneity that otherwise might be impossible to explore.
Mortality deceleration was observed for many invertebrate species , but the evidence for mammals is controversial.
Mortality decreased with advancing age in NHAP , and the reverse was true for CAP.
Mortality differed significantly between groups ( P < @number@ c = @number@ ) .
Mortality differentials are stable across age groups but converge when health deteriorates.
Mortality due to cardiovascular diseases is significantly reduced ( SMR : @number@ @percent@ CI : @number@ @date@ , p = @number@ ) among rowers.
Mortality follow-up was assessed until the end of @number@
Mortality from MI was increased for diabetes duration up to @number@ years , while stroke-specific mortality increased progressively with diabetes duration.
Mortality had a U-shaped relationship with A1C.
Mortality hazard ratios ( HRs ) after incident AD dementia were estimated per 10-year age strata from proportional hazards models.
Mortality , hospitalization , and functional decline were evaluated.
Mortality , hospitalizations , falls , and functional dependency were evaluated during @number@ ( second wave of the study ) .
Mortality increased @number@.6-fold between @number@ and @number@
Mortality increased obviously among those aged @number@ or above.
Mortality information was obtained from The Norwegian Institute of Public Health in @number@ by which time @percent@ of the participants were deceased.
Mortality in MCI cases versus cognitively normal ( CN ) individuals was estimated using Cox proportional hazards models.
Mortality in the hospital was @percent@ , and there was no difference in each group.
Mortality is increased at @number@ and @number@ years in fallers who experienced indoor falls.
Mortality is infrequent , but may be increasing over the years.
Mortality is up to @percent@ , depending on the precision of diagnostic criteria.
Mortality monitoring in Azerbaijan 1971-2008 revealed bi-annual stranding peaks in late spring , following the annual moult and during autumn migrations northwards.
Mortality ( @number@ vs. @number@ % ) and major morbidity ( @number@ vs. @number@ % ) rates were similar.
Mortality peaks comparable to epizootic years were also recorded in the 1970s-1980s , consistent with previous undocumented CDV outbreaks.
Mortality-predictive abilities of the full-MNA and MNA-SF were compared using Cox regression analysis and Net Reclassification Improvement ( NRI ) .
Mortality rates differed significantly between high and low testosterone tertiles in men , but did not differ significantly between middle and low tertiles.
Mortality reduction in older MAs requires attention to socioeconomic disparities and disease factors.
Mortality requires large sample size and only partly related to the infectious process.
Mortality risk for low-income men was also lower in higher conflict marriages compared with being never married or previously married.
Mortality risk increased with increasing quartiles of IL-6 , sCD14 , and D-dimer regardless of HIV status.
Mortality risks were examined using Cox proportional hazard models adjusting for confounders.
Mortality risk was higher in participants with dynapenia without central fat distribution compared with the reference group.
Mortality risk was initially reduced by functional characteristics , but disappeared after full adjustment for the various health variables.
Mortality risk was not increased among physically independent subjects with or without cognitive impairment , and physically disabled subjects with intact cognition.
Mortality risk was significant ; @percent@ died within @number@ months , @percent@ within @number@ months , and @percent@ within @number@ months.
Mortality , serious morbidity and overall morbidity were not significantly different.
Mortality trend analysis also found higher CVD deaths in people age 15-19 in Hunan residents.
Mortality was adjudicated by obtaining death certificates.
Mortality was also followed-up.
Mortality was ascertained during follow-up and from the National Death Index.
Mortality was ascertained during follow-up and with the National Death Index.
Mortality was compared between age groups adjusting for sex and preexisting morbidity using 50-64-year-olds as reference.
Mortality was derived from register-based information and linked to the baseline data.
Mortality was determined at @number@ days and @number@ year.247 unilateral and @number@ bilateral thoracenteses were performed.
Mortality was determined by Veteran Affairs Death Registry , which was linked to the National Death Registry.
Mortality was high ( 6-22% ) .
Mortality was higher in older patients.
Mortality was inversely associated with the number of occasions on which participants reported high enjoyment of life.
Mortality was monitored from @number@ until @number@
Mortality was unrelated to the CDIS CDT ( p = @number@ ) and the Shulman CDT ( p = @number@ ) .
Mortality , weight loss and sarcopenia were the main outcomes measured.
Mosaic events are detected from analyses of intensity parameters of linear stretches with deviations in heterozygous probes of single nucleotide polymorphism microarrays.
Mosaicism can have a wide range of effects , from early pregnancy loss , to organ specific pathology , to modification of clinical syndromes.
MoS at recovery leg touchdown were significantly lower in the unexpected soft trials compared to the baseline , indicating a less stable posture.
Mosquitoes carrying the WMelPop strain , however , are not likely to persist as it reduces the mosquito lifespan by up to @percent@.
Most activities in this area focus on the elderly.
Most AD cases are sporadic where age represents the greatest risk factor.
Most adhesives presented decreased UTS after water-storage.
Most AD patients become dependent on their relatives , i.e. family caregivers.
Most adult NSCs are quiescent , express glial markers , and depend on Notch signaling for their self-renewal and the generation of neurons.
Most AEs were mild or moderate.
Most AEs were mild or moderate and did not result in discontinuations.
Most aging literature compares young with old runners without accounting for the progression of biomechanics throughout the lifespan.
Most Americans will have a disability at some point in their lives.
Most anaemias are due to a deficiency , chronic inflammation or comorbidity.
Most antidepressants present to some extent pharmacokinetic sex differences , which often are further accentuated by gonadal hormones.
Most aortic anatomical variables were age-dependent.
Most are easily treatable.
Most articles investigated acceptance of technology that enhances safety or provides social interaction.
Most articles were conducted in Scandinavian countries and used a phenomenological design.
Most aspects of mammalian function display circadian rhythms driven by an endogenous clock.
Most asymptomatic patients with or without cholecystectomy have a normal common duct diameter.
Most attention has been given to beneficial effects in insults involving cancer , aging , cardiovascular system , inflammation and the central nervous system.
Most authors mention server-based decision support components , but only few papers provide details about the system architecture or the knowledge base.
Most available sirtuin modulators are little understood mechanistically , hindering their improvement.
Most BBDP subjects are enrolled as cognitively normal volunteers residing in the retirement communities of metropolitan Phoenix , Arizona.
Most biological networks are efficient and formed by sparse connections , and the KCT can potentially reveal sparse connectivity patterns that are biologically informative.
Most birds ( Aves ) , having higher rate of metabolism , live two-to-three times longer than mammals of the same size.
Most cancers emerge in elderly and immune-comprised hosts implying an important role for cancer immune surveillance.
Most cancers rely on aerobic glycolysis to generate energy and metabolic intermediates.
Most carbonylation sites ( @number@ @percent@ ) resulted from oxidation of lysine residues ( aminoadipic semialdehyde ) .
Most cases of AFFs occurred in older people aged @number@ years and above.
Most cases of cervicofacial actinomycosis are odontogenic in origin.
Most cases of PD of the spine were overlooked or confused with other entities by the radiologists.
Most cases presented with advanced disease , though some down staging was observed in period @number@ ( 1998-2002 ) .
Most cases that tolerated an adequate dose improved on levodopa.
Most cells and tissues in the human body have vitamin D receptors that stimulate the nuclear transcription of various genes to alter cellular function.
Most centers ( @percent@ ) had been using OBT-A for > 1 year.
Most change appeared to occur before @number@ years of age , after which minimal change in distance was found.
Most characteristics were ascribed to young adulthood.
Most childhood cancer survivors need life-long care with specialized late-effects surveillance and screening.
Most children ( ~90% ) who use dietary supplements use a multivitamin-mineral or multivitamin product.
Most circRNAs are generated by back-splicing events from exons of protein-coding genes.
Most cities , counties , and neighborhoods are not designed for an aging population.
Most classes of antihypertensive medications may be used as first-line treatment with the possible exception of α- and β-blockers.
Most clients had multiple issues and were referred for cognitive evaluation.
Most clinical training trials indicate that well-organized tasks are clinically effective for cognitive improvement.
Most clinical trials conducted so far suggest that prolonged antidepressant use in older adults is efficacious to reduce recurrence rates.
Most clinical trials exclude elderly patients from accrual considering aging a potential risk factor.
Most clinical trials have excluded old , frail individuals and have failed to take into account the effects of outcome interaction.
Most common breast cancer susceptibility variants have been identified through genome-wide association studies ( GWAS ) of predominantly estrogen receptor ( ER ) -positive disease.
Most common causative pathogen is Aspergillus fumigatus , followed by Aspergillus flavus and Aspergillus nidulans.
Most commonly affected by this specific type of fractures are young athletes , military or elderly subjects with metabolic bone diseases like osteoporosis.
Most commonly , drug evaluations are tested in ∼4- to 6-month-old mice.
Most considered variables are , for example , age , sex , general physical and mental health.
Most current analysis approaches focus on single traits , even though the final results from multiple traits are evaluated together.
Most current literature is supported by animal studies.
Most current therapies for CHF are medications , and biventricular pacing implantation as appropriated by cardiologists , or surgical interventions.
Most CVDs increased the risk of death for stages I-IIIB patients , but did not significantly impact survival of stage IV patients.
Most data on health service utilization studies assess utilization at one point in time , and does not examine transitions in health service utilization.
Most deaths in @number@ occurred in South Asia and sub-Saharan Africa.
Most definitions of frailty utilize US populations in their development.
Most developmental studies of face emotion processing show faces in isolation , in the absence of any broader context.
Most directors anticipated that the distance composition of their course offerings will remain unchanged or increase in the near future.
Most domain scores demonstrated good internal consistency reliability ( Cronbach's α ≥ @number@ ) .
Most drugs require lower initial dosing , slow titration , and lower maximum dosing when used with older adults.
Most ED visits in all patients , but especially in patients with more comorbidities , were for causes other than diabetes or mental health-related conditions.
Most elderly patients , particularly women , who have heart failure , have a preserved ejection fraction.
Most elderly subjects ( @percent@ ) with unclassifiable ILD had an imaging pattern inconsistent with usual interstitial pneumonia ( UIP ) .
Most elderly Taiwanese preferred to have private home carers ( usually from neighboring countries ) over institutionalization.
Most elders in the sample were middle-class , cognitively intact , independent , and in good health.
Most encountered ethical objections originate from the view that people are , or should be , independent and self-determinant.
Most enlist support from various partners , and use numerous methods for community engagement.
Most episodic memory tests used in clinical settings assess intentional memory.
Most epithelial cancers arise from this normal mutation rate.
Most estimated sensitivities and specificities were @number@ per cent or more , indicating that the seven algorithms correctly identified individuals with the target disease.
Most evidence supports a similar incidence of coronary heart disease and a higher incidence of cerebrovascular disease among Arctic Inuit than seen in western populations.
Most evident is the participants ' reluctance to acquire new objects or even to replace broken things.
Most exercise programs were multicomponent.
Most existing health and aging literature have used cross-sectional or short-term available panel data to identify age or period effects ignoring cohort effects.
Most experts support TRT for older men with frank hypogonadism and symptoms.
Most extracellular ICAM-1 immunoreactivity was coextensive with GFAP-immunoreactive astrocytes in both groups.
Most failures were in adhesive at dentin-cement interfaces ; no failure occurred between zirconia and cement.
Most falls ( @percent@ ) occurred within @number@ month of discharge.
Most families considered environmental factors to be \ "barriers \ " ; these were poverty , unemployment , and single-parent family structure.
Most forensic age predictor models have been developed based on blood DNA samples , but additional tissues are now also being explored.
Most forms of botulinum toxin type A currently used require reconstitution , which is very inconvenient for users.
Most freckles were observed in the inferior temporal quadrant.
Most frequent and dreaded complication of herpes zoster is postherpetic neuralgia ( PHN ) .
Most frequent diagnoses were ischemic colitis ( @percent@ ) , diverticulosis ( @percent@ ) , and colorectal malignancies ( @percent@ ) .
Most frequent reasons for model choices were health , activities , and social resources.
Most fRPE retained RPE markers.
Most genome-wide association studies have been of European individuals , even though most genetic variation in humans is seen only in non-European samples.
Most Group @number@ patients ( n = @number@ @percent@ ) agreed that the instrument adequately assessed the psychological impacts associated with CFL.
Most healthy individuals infected with B. microti are asymptomatic , but may be at risk for chronic infection.
Most healthy organisms are made up of a multitude of cells and cell types , but none of these cells acts alone.
Most heathcare and service providers have little experience with this group and limited understanding of non-normative gender identification.
Most hip fractures in the elderly occur on falling from standing height , usually sideways or backwards.
Most HIV-infected patients receiving cART have some persistent immune dysfunction characterized by chronic immune activation and premature aging of the immune system.
Most human cancer types result from the accumulation of multiple genetic and epigenetic alterations in a single cell.
Most human cells lack sufficient telomerase to maintain telomeres , hence these genetic elements shorten with time and stress , contributing to aging and disease.
Most human neurodegenerative diseases are sporadic , and appear later in life.
Most , if not all , cell types release extracellular vesicles , which then enter the bodily fluids.
Most important , an increasing proportion of older people remain living in their ordinary homes despite health decline and disability.
Most important , both age groups showed strong evidence for memory-based processing of the noun phrases in the transfer task.
Most important for avoiding low income are other family income sources , good health , and employment-related pension income.
Most important , however , visual distraction was disproportionately larger in older adults.
Most important , independent of mean RTs , variability allowed predicting dual-task practice benefit in both age groups under specific conditions.
Most important , it provides a specialized environment for the selection of rearranged clones that will function appropriately in the adaptive immune response.
Most importantly , AET improved inhibition but not flexibility , and motor learning skill , in both groups.
Most importantly , families need our help now.
Most importantly , generation of sAPPβ-sAPPβ dimers is dependent on APP-palmitoylation while total sAPPβ generation is not.
Most importantly , long-term dutasteride therapy resulted in reduction in total T levels , contributing to a state of hypogonadism.
Most importantly , non-completers had a significantly higher alcohol consumption compared with completers.
Most importantly , our AD-CSF-indices cutoff was highly similar to that reported in Western studies.
Most importantly , residents who consumed sorbet salivated more on average in comparison with residents who consumed water.
Most importantly , significant national efforts and policy proposals substantiate these efforts and will be reviewed.
Most importantly , the detection of vertical modifications was preserved in older relative to young adults whereas the detection of horizontal modifications was markedly diminished.
Most importantly , they secrete a unique pattern of proteins that is distinct from the canonical SASP and might reflect specific processes of skin aging.
Most importantly , we discuss key ways to modifying the design of tasks based on studies we review.
Most important , we determined that collaborative multi-ADC research articles are consistently of higher impact than AD articles as a whole.
Most important , we found that AhR antagonist efficiently revert the aging of skin cells.
Most impressive was the significantly greater improvements produced by the test regimen over the control regimen for nearly every grading parameter.
Most improvements were evident after @number@ months , with more-limited improvements from Months @number@ to @number@
Most included articles provided sufficient detail about data collection methods , yet limited detail about methodologies supporting the study designs and / or data analysis.
Most individual markers showed low sensitivity ( below @percent@ ) for detecting CRC , along with high specificity close to @percent@.
Most individuals ( @percent@ ) were females , who often accessed the Internet ( @percent@ ) and had different educational levels.
Most individuals received pharmacologic treatment ( @percent@ ) ; however , @percent@ of individuals had uncontrolled hypertension.
Most infants ( @percent@ ) had age- and gender-adjusted NE-17OHP and E-17OHP levels within the recalculated RI.
Most infants with mild postnatal renal dilatation can be investigated with only one further sonogram at @number@ months of age.
Most injuries occurred in the right lobe.
Most instruments covered multiple domains or focused on care for physical symptoms , psychological or social aspects of care.
Most integrative therapies require further investigation via well-designed controlled trials with meaningful outcomes.
Most interestingly , however , we found that the early AD samples were biased to one of two phenotypes , M1 or M2a.
Most interestingly , the mtDNA damage was positively correlated with the grading level of AMD , whereas repair capacity was negatively correlated.
Most interventions involved both active and receptive musical elements.
Most interventions proved partially effective , in terms of gender preference ( women ) or type of information retained or media preferred.
Most likely , however , the sequence-specific transfer was an epiphenomenon of the comparatively low rate of learning among the middle-aged adults.
Most lipid microemboli from cardiac surgery pass through the brain in a few days , but some remain for weeks.
Most literature on NPC disease focuses on neurological and liver manifestations.
Most local tolerability events were mild and transient.
Mostly benign , it is necessary to differentiate them from malignant tumours such as fibrosarcomas.
Mostly , care team members received specific training but such training did not necessarily incorporate the IPE approach.
Most macroscopic skeletal aging techniques used by forensic anthropologists have been developed and tested only on reference material from western populations.
Most Marinesco bodies exhibited ubiquitin expression.
Most markers used lack sufficient specificity and false positives and negatives in common.
Most mentioned role models from their family , including parents and grandparents.
Most men were white and asymptomatic.
Most mitral valve parameters increased linearly with patient size.
Most molecular hallmarks of cellular senescence have been identified in studies of cells aged in vitro by driving them into replicative or stress-induced senescence.
Most mutations in ABCC6 are missense , and many preserve transport activity but are retained intracellularly.
Most myocardial bridges involve the left anterior descending artery and are observed in 14-35% of patients.
Most neurodegenerative disorders are characterized by accumulation of undegraded misfolded proteins and are currently associated with autophagy-lysosome dysfunctions.
Most neurons are generated during development and are not replaced during adulthood , even if they are lost to injury or disease.
Most never users ( @percent@ ) had never discussed their symptoms with a health care professional ( HCP ) .
Most NH residents with APN or PA PCPs had providers with @percent@ or more of Medicare billings generated in NHs.
Most ( n = @number@ @percent@ ) patients died during the study period.
Most nonablative laser systems emit light within the infrared portion of the electromagnetic spectrum ( 1000-1500 nm ) .
Most notable was the statistically significant inverse correlation between increasing number of medications and intake of fibre.
Most notably , decrease in function of recent memory , ability to increase tempo , long-windedness , distractibility , and blunting were better identified.
Most notably , perceived health and functional level decreased.
Most notably , the associations between physical and mental functioning with SPSA were significantly lower in the O-O versus Y-O group.
Most notably , the research program worked with planners to adopt the United States Environmental Protection Agency's Aging Initiative model for Philadelphia.
Most number of patients , particularly adult and older women with temporomandibular disfunction suffers from pain reaction in maxillofacial area.
Most of AEs were considered mild.
Most of alterations found on the photoaged skin had formerly been considered to be caused by UVB wavelengths.
Most of South America countries have a hybrid of public and private healthcare system.
Most of strains ( @percent@ ) were isolated from urine , and diabetes was the most common underlying disease ( @percent@ ) .
Most of such drugs are developed , aiming at the application to age-related muscle reduction ( sarcopenia ) and osteoporosis.
Most often , FPA develops after an injury or angiographic access to the femoral artery with bleeding into the adjacent tissue.
Most of the analytical models of dose-response functions that have been constructed are biased by the assumption that no downregulation exists.
Most of the anthocyanins had significant differences in concentration amongst the wines sealed with the six bottle stoppers at the 18-month point.
Most of the beneficial effects of antioxidants are considered to derive from their influence on the immune system.
Most of the cases exhibit a mixed form.
Most of the cases of bladder tamponade in the women occurred in the elderly and were caused by cystitis.
Most of the clinically used anti-osteoporotic drugs are administered systemically and have demonstrated some side effects in non-skeletal tissues.
Most of the clinical manifestations of these changes become apparent after menopause and throughout aging in women.
Most of the developmental and cell signaling pathways and ∼75% human disease-related genes are conserved between human and Drosophila.
Most of the differentially regulated proteins are involved in molecular transport , nervous system development , synaptic plasticity and apoptosis.
Most of the elderly used the local herbals together with conventional medicines.
Most of the existing comparisons focus on Western Europe and the United States , often relying on older data.
Most of the expenditure for the old people was in hospital.
Most of the fractures were located between T10 and L2 and a long construct was performed in @number@ cases.
Most of the genes identified by using non-biased genomic techniques are associated with inflammation , immune response and stem cells.
Most of the health professionals used the guidelines for management of elderly patients ( @percent@ ) .
Most of the identified genes play a role in mitochondrial activity and integrity , and this was demonstrated mostly in neuronal cells.
Most of the identified studies reported a significant positive association of PA with HA , six reported a non-significant.
Most of the Ig gene mutational lineage trees were small and narrow.
Most of the improvement was observed by three weeks and was sustained through nine weeks.
Most of the interviewees lacked knowledge and held misconceptions toward LUTS , which prevented them from pursuing medical advice.
Most of them are engaged in immune evasion or inhibition of cell death , possibly , resulting in a symbiosis between virus and host.
Most of them are expressed in Sertoli cells , indicating that they are candidates to be directly regulated by Rhox5.
Most of them can be solved at primary care , with the help of consultant specialist.
Most of them had already been treated by bisphosphonates but without calcium and vitamin D supplements.
Most of them have been verified for their secretion by PVAT ; however , their paracrine functions are unknown.
Most of them have shown benefits in the treatment of melasma and skin aging.
Most of the microtubule-promoting factors were up regulated during differentiation of N1E-115 cells , while microtubule-destabilizing proteins were down regulated.
Most of them were medical doctors ( @percent@ ) , and their primary field of practice was geriatrics ( @percent@ ) .
Most of them were unwilling to seek social support and were even embarrassed to share this topic with their peers.
Most of the myocyte population was represented by mononucleate cells with tetraploid nuclei ( @percent@ ) .
Most of the new ones are modified versions of the original collagen and hyaluronic acid gels.
Most of the @number@ recommendations were found to still be valid @number@ years later.
Most of the observers perceived in-depth intervals to be significantly smaller than fronto-parallel intervals , a finding that is consistent with previous studies.
Most of the older Black South Africans continue to live in extended household structures with children , grandchildren , and other kin.
Most of the osteoporosis medications were developed for the treatment of postmenopausal osteoporosis and some are licensed for use only in women.
Most of the osteoporosis susceptibility genes ( @percent@ ) also were confirmed to be regulated in the same direction in the validation group.
Most of the participants also sought alternative treatments and developed self-help methods to cope with their symptoms.
Most of the participants found the game easy to use and clear in its content.
Most of the participants showed high attitude scores.
Most of the patients ( @percent@ ) originated from rural areas in ES , @percent@ being farmers.
Most of the people who did the notification were patients aging up to @number@ years old ( @percent@ ) , and @percent@ from female sex.
Most of the pericentromeric and interstitial telomeric sequences in fish are possible relicts of chromosome fusion events.
Most of the predictors identified can lead to targeted therapeutic options with a view to preventing or delaying institution admission.
Most of the previous studies which investigated the relationship of the occupational factors and musculoskeletal symptoms had adopted questionnaire survey.
Most of the proposed statistical methodology for describing decline relies upon distributional assumptions that may not hold.
Most of the proteins were under-represented in older compared with mature women.
Most of the recommendations in existing clinical guidelines are based on expert opinions , extrapolations from data obtained in younger patients , or theoretical considerations.
Most of the respondents ( @percent@ ) were defined as having positive well-being.
Most of the sample ( @percent@ ) were female.
Most of these abnormalities had not been diagnosed or treated previously.
Most of these abnormalities remain unnoticed and untreated.
Most of these cases are not associated with traditional risk factors for CKD , such as aging , diabetes mellitus , and hypertension.
Most of these comparisons support an important role for membrane fatty acid composition in the determination of longevity.
Most of these decreases were seen in cytomegalovirus ( CMV ) seropositive subjects.
Most of these diseases are chronic , need continuous care and treatment with limited improvement and high costs.
Most of these effects can be mediated by classical MR and its crosstalk with different signaling cascades.
Most of these genes showed similar patterns in human MDS and AML.
Most of these investigations are related to the analysis of individuals suffering from neuromuscular disorders.
Most of the senescence hallmarks were common for both RS and SIPS ; however , some differences were observed.
Most of these patients will require treatment with a combination of antihypertensive agents to reach this goal.
Most of these reports have focused on microRNAs implicated in alterations of amyloid-β and tau.
Most of these studies had no comprehensive clinical diagnosis on cognitive function.
Most of these theories are complementary , rather than competing , with many areas of intersection and reciprocal influence.
Most of these tumors are stage I tumors.
Most of the sleep complaints related to low HRQoL were found among those with a high degree of comorbidity.
Most of the SN components showed differences in the GMV between the HOC and AD and between the aMCI and AD.
Most of the studies deal with the manipulation of telomerase enzyme in cancer and aging either by synthetic oligonucleotide or by natural phytochemicals.
Most of the studies did not report any outcome of harm with enteral nutrition use in dementia patients compared with patients without dementia.
Most of the studies investigating epigenetic effects of natural polyphenols have focused on their beneficial effects in cancer treatment.
Most of the studies ( n = 7 ) were conducted among breast cancer survivors.
Most of the studies were cross-sectional and examined measured particulate matter effects on CVD outcomes and indicators.
Most of the symptoms were less correlated with other variables after @number@ weeks of R6 treatment.
Most of the TB-related deaths occurred early ( median survival : @number@ days ) , and the patient died of septic shock.
Most of the tested composites showed significant differences in fluorescence both before and after aging ( P < @number@ ) .
Most of the tests showed a good sensitivity and specificity to differentiate the diagnostic groups.
Most of the tolerable upper intake levels for the micronutrients , published by authorized institutions , were set without considering the long-term effects of overdosing.
Most of the toxicity was of grade I and grade II.
Most of the unique variance in depression severity was explained by psychological unmet needs , more in particular by needs representing psychological distress.
Most of the vulnerable inpatients identified by CAS alerts would not have otherwise had a geriatric medication review.
Most of those who changed class moved to the Healthy class.
Most older adults fell while walking , @percent@ inside their homes.
Most oxidative DNA lesions are repaired via the base excision repair ( BER ) proteins including 8-oxoguanine DNA glycosylase @number@ ( OGG1 ) .
Most parameters were independent of age and ethnicity , yet greater in males than in females.
Most participants did not have any abnormalities.
Most participants did not report seeing more than one critically ill child per month.
Most participants received instrumental support from others ( @percent@ ) and also provided emotional support to others ( @percent@ ) .
Most participants reported initially enrolling in the registry for societal benefit.
Most participants reported that they were somewhat or very satisfied with the footwear ( @percent@ ) and orthoses ( @percent@ ) provided.
Most participants reported that they would manage home maintenance challenges using compensation ; the most frequently mentioned compensation strategy was using tools and technologies.
Most participants sought information from other people as a primary method of route planning.
Most participants were low educational level including illiterate ( @percent@ ) and elementary school ( @percent@ ) .
Most participants wore accelerometers for @number@ days.
Most pathologic conditions detected by histologic analysis are caused by H pylori infection , but the causes of many others are unknown.
Most patients ( 541 / 711 , @percent@ ) with signs of OA showed proliferative changes of OA.
Most patients after HBeAg seroconversion become \ "inactive HBsAg carriers \ ".
Most patients benefit from levodopa , and should be tried on the drug when diagnosis of parkinsonism is made.
Most patients choose to have this performed underline tumescent anesthesia when given the choice of sedation versus local anesthesia.
Most patients completed all sex-related items on the intake form ; @percent@ answered at least one.
Most patients die from the consequences of budding hundreds of skin cancers in the absence of photoprotection.
Most patients had physician-reported depression onset after age @number@ years ( @percent@ ) and moderately severe depression ( @percent@ ) .
Most patients ( @percent@ ) agreed to be vaccinated following their physician's advice because of their age or their chronic conditions.
Most patients ( @percent@ ) and physicians ( @percent@ ) rated the aesthetic effect of Voluma as improved.
Most patients ( @percent@ ) described marked or moderate satisfaction with the treatment.
Most patients ( @percent@ ) had cosmetic improvement according to the independent evaluation.
Most patients ( @percent@ ) stopped GH before transfer , at @number@ years ( median ) , despite persistence of GHD.
Most patients ( @percent@ ) were male , @percent@ had diabetes , @percent@ had hypertension , and @percent@ had coronary artery disease.
Most patients ( @percent@ ) would undergo a DRE again and @percent@ had considered it better than they had imagined.
Most patients presented with no specific , localizing neurological complaints.
Most patients received an immunomodulator and responded well.
Most patients reported none or only mild stinging and burning during and after treatment.
Most patients report good results ; however , some patients here experienced variable degrees of side effects.
Most patients require brow reshaping by restoration of the brow apex lateral to the level of the outer corneal limbus.
Most patients survived to the 6-month time point after enrollment.
Most patients were disabled.
Most patients were over @number@ years of age and female , and about half of them had dementia.
Most patients were treated initially with coal tar preparations and shampoos , then often progressing to topical potent corticosteroids.
Most patients were treated with OACs in both age groups.
Most patients were \ "very satisfied \ " ( @percent@ ) or \ "quite satisfied \ " ( @percent@ ) with treatment.
Most patients who underwent surgical correction were satisfied.
Most patients with C albicans infections can be successfully treated with maintenance antifungal therapy , usually with fluconazole.
Most patients with ductal carcinoma in situ of the breast ( DCIS ) are eligible for breast conservation treatment.
Most patients with gastric cancer have , or have had , prior H. pylori infection.
Most patients with lower respiratory tract infections or urinary tract infections ( 77-91% ) received antibiotic treatment.
Most patients with mild cognitive impairment ( MCI ) are thought to be in an early stage of Alzheimer's disease ( AD ) .
Most patients with NFPAH had serum prolactin levels less than @number@ ng / ml.
Most patients would have liked their family physician to be more involved in all aspects of cancer care.
Most PA was completed in the morning hours and increased as the winter month's transitioned to spring ( February through April ) .
Most payors felt that AD was underdiagnosed and undertreated in their country ( @percent@ and @percent@ , respectively ) .
Most PD patients possessed normal cue-information memory but extra-retinal mechanisms for pursuit preparation and execution were dysfunctional.
Most PD patients suffer from somatomotor and oculomotor disorders.
Most people deal with intrusive life events such as cancer and the care trajectory together with their intimate partners.
Most people with HIV infection become aged , and older adults have been contracting HIV infection.
Most ( @percent@ ) ADR-related admissions were considered preventable.
Most ( @percent@ ) adverse drug reaction-related repeat admissions were considered ' preventable'.
Most ( @percent@ , CI : @number@ @number@ ) participants were likely to enroll in a registry.
Most ( @percent@ ) do not prescribe probiotics prophylactically.
Most ( @percent@ ) had undergone Duhamel operation , and @percent@ had aganglionosis confined to the rectosigmoid.
Most ( @percent@ ) were admitted through the emergency department.
Most ( @percent@ ) were robust ; @percent@ were pre-frail , and @percent@ frail.
Most photographs show adipose tissue infiltrating the structure of the fascia.
Most previous neuroimaging studies of age-related brain structural changes in older individuals have been cross-sectional and / or restricted to clinical samples.
Most previous studies evaluating SSMT have employed two-dimensional image analysis of magnified pictures captured by a video microscope.
Most previous studies in this area have used correlational imaging techniques and framed Schadenfreude and envy as unified and monolithic emotional domains.
Most professionals followed the protocol , with only minimal deviations.
Most professional societies agree that HT should not be used for chronic disease prevention.
Most prominent decrease in angiomotin content in dermal blood vessels was found in 61-85 years age-group.
Most rated the curriculum of high quality and relevant to their practice.
Most realists remained realists ; health optimists and pessimists tended to become realists.
Most recently , distinct omics datasets have been integrated , and sophisticated mathematical models have been applied to the DDR.
Most recommendations for treatment of ONJ are based on position papers and case reports , while evidence-based treatment paradigms are lacking.
Most reported problems due to ageing were energy decline , muscle function decline , concentration lapses and memory deterioration.
Most reports are based on a single TSH measurement ; studies using frequent blood sampling are scarce and include a limited number of selected subjects.
Most required second retreatments to achieve optimal correction of their NLFs.
Most research with bilinguals has used speech stimuli to demonstrate differences in auditory processing abilities.
Most respondents lost at least one confidant from W1 and added at least one new confidant between waves as well.
Most respondents ( @number@ @percent@ ) believed that MOC should consist of a review individual case logs and patient outcomes for the aging neurosurgeon.
Most respondents ( @percent@ ) occasionally purchased organic chicken.
Most respondents ( @percent@ ) offer genetic testing to patients they define as having FALS and @percent@ to patients with sporadic ALS.
Most RNAs transcribed in mammalian cells lack protein-coding sequences.
Most sarcopenic individuals show signs of physical frailty , which leads to increases the prevalence of balance disorders , falls , fractures and pain.
Most SCH patients have mild cases ( thyrotropin ≤10 mIU / L ) .
Most scientific literature reports that aging favors the development of cancers.
Most significant increases of regional nodes occur in the posterior cingulate cortex , which plays a pivotal role in the functional default mode network.
Most significantly , DNA damage accumulates during senescence as well as during long-term quiescence at physiological oxygen levels.
Most sleep events , which define the sleep stages , are reduced with age.
Most smokers smoke their first cigarette in early adolescence.
Most specimens demonstrated convex caudal morphology.
Most striking increase was seen in the age group 70-79 , in face and head locations and among residents in southern Norway.
Most strikingly , induced SHP-2-deficient mice developed severe skeletal abnormalities , including kyphoses and scolioses of the spine.
Most strikingly , it is closely integrated with autophagy and the selective brand of this quality control process , mitophagy.
Most strikingly , they demonstrated that bypass can also occur in older adults.
Most stroke patients are also older than the young populations on which assumptions of neurovascular coupling and the typical analysis pipelines are based.
Most studies aiming to identify genetic susceptibility factors for LOAD have focused on non-Hispanic white populations.
Most studies analyzed only the genes and their functions representing each senescence phase without considering gene-level interactions and continuously perturbed genes.
Most studies are cross sectional and take place within specific subpopulations.
Most studies compared different antihypertensive agents and / or placebo groups.
Most studies excluded did not encompass caregivers ' perspectives.
Most studies focused on women with breast cancer and adherence to adjuvant hormonal therapy.
Most studies focus on generic aspects of competence and adherence , rather than taking into account treatment-specific aspects or specific challenges of the clientele.
Most studies found a benefit with the intervention compared to control.
Most studies found that overall QOL was maintained or improved in patients receiving either aromatase inhibitors or tamoxifen but patients reported different adverse effects.
Most studies have confirmed the positive impact of resistance training on muscle mass and functional capacity in aging adults.
Most studies have evaluated the pre-clinical and initial stages of AD through clinical trials using Magnetic Resonance Imaging.
Most studies have examined incident hypertension as an outcome , and few have examined effect modification.
Most studies have focused on age-related effects , whilst puberty-related changes are not well understood.
Most studies have focused on JPS of the knee joint while literature for other joints especially for hip JPS is scarce.
Most studies have focused on the role of telomeres as a tumor suppressor mechanism.
Most studies have primarily used single-joint or planar paradigms to examine age-related changes in proprioception.
Most studies have used in vitro approaches and various animal models , but observed changes translate poorly to human healing conditions.
Most studies have used in vitro approaches and various animal models , but observed changes translate poorly to human healing conditions.
Most studies included both younger adults and older adults.
Most studies of calcification were performed in Western countries.
Most studies on aging and marathon have analyzed elite marathoners , yet the latter only represent a very small fraction of all marathon participants.
Most studies on benzodiazepines emphasize overconsumption and warn of addiction , especially by older adults.
Most studies only examined forwards stepping despite considerable bio-mechanical and visual differences between the forwards and backwards directions.
Most studies only used TV viewing time as an indicator of sedentary time.
Most studies on natural killer ( NK ) cells and aging have focused on overall cell numbers and global cytotoxic activity.
Most studies on primitive reflexes have reported an association between such reflexes and brain damage , and the clinical symptoms of dementia.
Most studies on sensory extinction have focused on selected patients with subacute and chronic right hemisphere lesions.
Most studies on surgical procedures for cartilage focus on young patients because these procedures are generally not considered suitable for older patients.
Most studies on the prevalence of supplement use in the United States were cross-sectional or evaluated trends in limited variety of supplements.
Most studies on this subject have used age cutoffs as a proxy for life expectancy.
Most studies showed a rise in total health care expenditure.
Most studies to date have examined age differences in functional connectivity via static indices that are computed over the entire blood-oxygen-level dependent time series.
Most studies to date have focused on brain-derived neurotrophic factor ( BDNF ) as a signaling target for the enhancement of neuronal function by exercise.
Most studies use waist circumference measurements to determine statistical significance and efficacy.
Most subjects ( 72%-79% ) complied well with the exercise program.
Most subjects agreed that the digital nutritional education package can increase their nutritional knowledge for a healthy lifestyle and is easy to use.
Most subjects felt the treatment brought them ' harmony' , ' self-esteem / confidence ' or ' youth'.
Most subjects ( @percent@ ) had a sexual partner and most ( @percent@ ) reported recent sexual intercourse.
Most subjects ( @percent@ ) had Fitzpatrick's skin phototypes IV , V , and VI.
Most subjects ( @percent@ ) initially switched to incobotulinumtoxinA because of lower cost.
Most suitable localizations to evaluate skin aging are cheek , forearm and neck.
Most surgeons were male , with a mean age of forty-nine years , with mainly adult practices ; @percent@ reported having a subspecialty.
Most surrogates were daughters ( @percent@ ) , sons ( @percent@ ) , or spouses ( @percent@ ) .
Most system to date have predominantly focused on one-on-one human robot interaction ( HRI ) .
Most TEAEs and drug-related TEAEs were mild or moderate in severity , and there were no trends across subgroups.
Most telomere research is done in the context of human disease.
Most tissues showed relatively similar levels of protein oxidation.
Most toxicities were not severe.
Most treatments were administered in line with local clinical guidelines and were rated as effective.
Most true hyponatremias are grouped in the latter category.
Most units experienced major difficulties in including patients , leading to excluding two of the eight units from participation.
Most users reported high satisfaction with MyFitnessPal , but logins decreased sharply after the first month.
Most US interviewees reported poor knowledge about self-care post-discharge and poor quality of home adaptations compared to the UK group.
Most were mild to moderate in severity and resolved completely.
Most were mild to moderate in severity , and the most common adverse events were headache and rash ( n = @number@ each ) .
Most were people about the origin of the workers and peasants , mainly in vocational education.
Most who reduced alcohol consumption and heavy drinking did so because they thought it would benefit them.
Most women believed that vaginal symptoms are a normal part of aging and they just need to cope with the symptoms.
Most women resumed sexual activity within @number@ weeks of their MI.
Most women who discussed sex with a physician initiated the discussion themselves.
Most worryingly , recent data reports accelerated cognitive decline in adolescents associated with poor diet ( high fat and calorie intake ) .
Most would tell others about it ( @percent@ ) .
Mothers and their 9-month-old infants wore head-mounted eye trackers while mothers carried their infants in a forward-facing infant carrier through a series of indoor hallways.
Mothers of cases received less betamethasone , neonates had a lower GA , lower BW , lower Apgar , and needed more often intubation.
Mothers of @number@ children of the Copenhagen Perinatal Cohort ( 1959-61 ) recorded @number@ developmental milestones prospectively during the child's first year of life.
Mother's smiled predictably in response to infant smiles , for example , and infant smile initiations become more predictable over developmental time.
Mothers who were assessed in @number@ and in @number@ reported involvement in religious and secular organizations.
Motile and primary cilia ( PC ) are microtubule-based structures located at the cell surface of many cell types.
Motion coherence thresholds were assessed in @number@ children and adults aged 7-30years.
Motion monitoring by a two-tier gross and fine movement detector provided accurate detection and classification of movement , compared to annotations by an observer.
Motions performed were recorded using the Kinect sensor.
Motion was indicative of pain , with @percent@ of time spent moving while in pain versus @percent@ while not noted as in pain.
MOTIVATION : Because susceptibility to diseases increases with age , studying aging gains importance.
MOTIVATION : It has been suggested that presumably distinct classes of genomic regulatory elements may actually share common sets of features and mechanisms.
Motivations are differentiated by age and gender.
Motivations to eat healthily and characteristics were measured with a self-reported questionnaire.
Motivation to exercise was measured at baseline and week @number@
Motivators for losing weight included being diagnosed with a health problem , health requirements for work , and financial incentives.
Motoneuron loss and change in their physiological properties accompany remodeling in the motor units.
Motor and mental development is normal.
Motor , autonomic , and cognitive assessments in idiopathic Parkinson disease and LRRK2 patients were compared with regression models.
MotorBrain supports the building of a large database of neuromotor data , which can be used for normative purposes in clinical use.
Motor control deficits during aging have been well-documented.
Motor dysfunction among TBI-exposed elders without PD has not been well characterized.
Motor features aside from tremor have been described in ET , including tandem gait difficulty.
Motor flexibility was quantified by an uncontrolled manifold ( UCM ) analysis.
Motor functioning resulted as a reliable predictor ( OR = @number@ @number@ % CI @number@ @date@ ) of re-hospitalisation in all the medical units.
Motor function in humans can be characterized with tests of locomotion , strength , balance , and endurance.
Motor functions improve during childhood and adolescence , but little is still known about the development of cortical motor circuits during early life.
Motor function was assessed by one-leg standing time with eyes open , leg extension power and grip power.
Motor function was assessed in 2007-2009 through objective tests ( walking speed , chair rises , balance , finger tapping , grip strength ) .
Motor function was measured prior to MCAO and @number@ days post-stroke.
Motor function was reduced in the older groups of mice for the locomotion , strength , and endurance subdomains ( p < @number@ ) .
Motor imagery and action planning are ubiquitous tasks , and older people are likely to spend more time engaged in them.
Motor impairment was evaluated qualitatively using the Unified Parkinson's Disease Rating Scale summary measures of motor skills and quantitatively using a digitized portable walkway system.
Motor neuron disease ( MND ) may present as an isolated lower motor neuron ( LMN ) disorder.
Motor output variability was quantified as the standard deviation and coefficient of variation ( CV ) of peak force and time to peak force.
Motor overflow is involuntary overt movement or covert muscle activity that cooccurs with voluntary movement.
Motor overflow refers to involuntary movement or muscle activity coinciding with voluntary movement.
Motor performance ( accuracy ) and perceptual performance ( quiet eye ) were examined across the four groups.
Motor performance declines with increasing age and it has been proposed that elder people might compensate for these deficits with increased cerebral activation.
Motor slowness and unbalance gait occur as well as decline of ability visual acuity and hearing let elderly people live in limited daily activity.
Motor unit potential ( MUP ) and NF MUP parameters were analyzed.
Motor unit recruitment and motor unit discharge rate ( MUDR ) have been widely studied in isometric conditions but minimally during velocity-dependent contractions.
Motor units also demonstrate age-related remodeling such as reduced number , muscle fiber atrophy , but an increased number of fibers per motor unit.
MOTS-c , a mitochondrially encoded open reading frame-derived peptide recently discovered by Lee et al.
MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance , as well as diet-induced obesity.
Mounting evidence and / or arguments document the crucial role of inflammation and immune-mediated processes in the pathogenesis of AMD.
Mounting evidence implicates a decline in mitochondrial function due to increased opening of the mitochondrial permeability transition pore ( mPTP ) .
Mounting evidence indicates that both genetic and environmental factors contribute to the etiology of PD.
Mounting evidence indicates that p63 proteins , which are homologs of p53 , are also involved in apoptosis under certain circumstances.
Mounting evidence indicates that serum cholesterol and other risk factors for cardiovascular disease intensify normative trajectories of age-related cognitive decline.
Mounting evidences from behavioral settings suggest that STC could be a physiological phenomenon.
Mounting evidence suggests reconceptualizing osteoarthritis ( OA ) as an inflammatory disorder.
Mounting evidence suggests that herpes simplex virus type @number@ ( HSV-1 ) is involved in the pathogenesis of Alzheimer's disease ( AD ) .
Mounting evidence suggests that normal aging itself is characterized by , among other features , a significant degree of metal ion dysmetabolism in the brain.
Mounting research now suggests a far more intimate relationship than previously recognized.
Mouse DCPP1 exerted its function on pancreatic cancer cells by activating intracellular signaling pathways involved in aggressive cancer phenotype of human pancreatic cancer cells.
Mouse embryonic fibroblasts from Safb1-null animals are immortalized in culture.
Mouse embryonic hippocampal ( mHippo E18 ) cells expressed NPY4Rs and their activation by PP consistently decreased somatostatin secretion.
Mouse hearts ( @number@ vs. 2-4 mo ) and human atrial tissue ( 75±2 vs. 55±2 yrs ) exhibited profound age-dependent reductions in I-R tolerance.
MouselabWEB software was used to trace participants ' processing strategies.
Mouse lines harboring CAPS-associated mutations in Nlrp3 have elevated levels of IL-1β and IL-18 and closely mimic human disease.
Mouse lines with impaired mitochondrial activity had critically short life spans or severe and rapidly progressing neurodegeneration.
Mouse lung was characterized by monophasic mH2A expression histograms at both ages , and an increase in mean staining intensity at old age.
Mouse models have shown that severe alterations of ROS metabolism can result in impairments of organ homeostasis and premature organ failure.
Mouse models in which hyperleucinemia was present displayed hippocampus-selective retromer deficiency.
Mouse models of cancer , in combination with cell culture studies , validate the critical role of GRP78 in tumorigenesis and tumor angiogenesis.
Mouse-model studies have revealed important functions for necroptosis in inflammation and suggested that it could be implicated in the pathogenesis of many human inflammatory diseases.
Mouse Neuro-2a cells expressing human APP695 ( N2a-APP cells ) were incubated with folic acid ( @date@ μmol / L ) .
Mouse serum biomarkers were assayed via MSD.
Mouse visual function was determined using visual evoked potentials , which revealed specific visual impairment in contrast sensitivity.
Mouth profile is the area which is manipulated during dental treatment.
Mouthwashes may disturb the healthy balance of the biofilm moisturizing the oral mucosa.
Movement based interventions such as imagery and action observation are used increasingly to support physical rehabilitation of adults during early aging.
Movement Disorders published by Wiley Periodicals , Inc. on behalf of International Parkinson and Movement Disorder Society.
Movement duration did not differ between the two groups.
Movement error was calculated as the absolute distance from the target.
Movement kinematics and error rates were compared for each viewing condition within and between subject groups.
Movement of individuals is a critical factor determining the effectiveness of reserve networks.
Movement , reproduction and aging of C. elegans were perturbed by the overexpression of SUMO-1 or @number@
Movements are a major source of artifacts in functional Near-Infrared Spectroscopy ( fNIRS ) .
Movement variability is often considered an unwanted byproduct of a noisy nervous system.
Movement variability was quantified as the standard deviation of finger acceleration and the variability of end position across trials.
Movement was measured by Actigraph accelerometers placed on the hip , wrist , and ankle.
MOVES holds utility for research , surveillance , evaluation , and interventions around the broad factors influencing mobility in older adults.
MOVES scores were lower for older , female , and non-white Canadians with worse health and lower socioeconomic status.
MOVES was also lower for those who live in less urban areas.
Moving away from an emphasis on investing in physical infrastructure , we believe that disaster risk reduction strategies should center on social infrastructure.
Moving forward , we determined its age-related neighborhood in which HCN3 , a known heart pacemaker channel , was included.
MOW clients are those individuals aged @number@ years and above who qualify for the service ; the volunteers are from community churches.
Moxibustion is a side-effect-free external therapy for relieving different clinical disorders.
Moxibustion was applied to ST @number@ GB @number@ GV @number@ and CV @number@ separately for @number@ moxa-cones , once every other day for one month.
MP and PP were detected in > @percent@ of urine samples and BP in > @percent@.
MPCs were collected from the gastrocnemius and plantaris of 3-mo-old ( young ) and 32-mo-old ( old ) animals.
MP density was assessed psychophysically.
MPH effects are dose-dependent and the dose-response relationship differs between cognitive domains.
MPHOSPH10 had estimated odds ratio ( OR ) of @number@ and the rs141620200 variant in SERPINA1 had OR of @number@
MPH use is associated with side effects and other adverse consequences , such as potential abuse.
M. plantaris mass of old mice was not significantly smaller than that of adult mice.
MPN showed elevated TA compared with controls ( @number@ vs. @number@ p = 0.020 ) .
MPOD in Type II diabetic patients was @percent@ lower than that in non-diabetics ( r = @number@ p < @number@ ) .
MPOD values were measured at 7° of eccentricity , using the one-wavelength reflectometry method ( Visucam @number@ Carl Zeiss Meditec ) .
MPOD values were reported in parameters including ' max ' and ' mean ' optical density ( OD ) .
MPOD was assessed using heterochromatic flicker photometry.
MPOD was measured at @number@ @number@ @number@ and @number@.75° eccentricity from the foveal centre using a heterochromatic flicker photometry based densitometer instrument.
MPOD was measured psychophysically.
MP optical density was measured in all subjects via customized heterochromatic flicker photometry.
MPP and the comparator were isocaloric and delivered the same amount of caffeine.
MPP ( + ) caused decrease in both phospho-Thr308 and phospho-Ser473 forms of AKT , and this was restored by NNGH.
MPP supplementation for @number@ weeks did not improve dual-energy x-ray absorptiometry ( DEXA ) measures of body composition or objective assessments of exercise performance.
MPS allows accurate DNAm determination of pre-selected markers and neighboring CpG-sites to identify the best age-predictive markers for the age-prediction tool.
MPS also had the typical absorption of -NH3 ( + ) , -NH2 and -COOH.
MPs are produced during shedding process in response to some stressing and stimulating factors , as well as during apoptosis.
MPs not only transfer membrane proteins from the cells of their origin but also convey phospholipids and microRNA to the distant cells.
MPTP activation and increased permeability has been shown to contribute to the events that lead to cell death.
MPV was measured at admission.
MP was the most common pathogen , whose detected rate was @percent@ ( 2637 / 10 @number@ ) .
MQI and functional changes to training and detraining were evaluated with repeated measures ANOVA and clinical interpretations of magnitude based inferences.
MQ improved in both groups after 13WE and 20WE , whereas the HV group improved more than the LV group at 20WE.
MQI was determined as power output from timed sit to stand ( STS ) , body mass , and leg length.
MQ was operationalized as ratio between knee-extension isokinetic strength and CT-thigh muscle cross-sectional area.
MRC CFAS is a population-representative study of aging and health including more than @number@ participants at baseline.
MR-Egger regression gave similar results , suggesting that directional pleiotropy was unlikely to be biasing the result ( intercept @number@ p = @number@ ) .
MRI analysis of prostate zonal anatomy enhanced our understanding of age-related changes in morphology and urinary symptoms.
MRI and PET images were normalized into common space , segmented and parcellated into gray matter ( GM ) regions.
MRI and WMH were assessed @number@ to @number@ years after HCT.
MRI-based volumetric measures were calculated for total intracranial volume , hippocampus , entorhinal cortex , and amygdala.
MRI examinations were reviewed and systematically coded by a single neuroradiologist.
MRI findings showed T2 hyperintensities in medial temporal lobe ( @date@ ) and basal ganglia ( @date@ ) .
MR images were T1-weighted and were obtained in the sagittal and axial planes.
MR imaging and R2 mapping in the basal ganglia and neocortex were done at 3T.
MR Imaging was performed on a 3T MR Scanner.
MRI markers of SVD included white matter hyperintensities ( WMH ) , lacunes , and enlarged perivascular spaces.
MRI-measured muscle volume of both thighs was used as the reference standard.
MRI measurements used for classification were performed using a region-of-interest analysis which included superficial , deep , and full-thickness cartilage.
MRI / MRA and WMH volume were stable or slightly better in @number@ of @number@ patients.
MRI participation has been shown to induce subjective and neuroendocrine stress reactions.
MRI revealed a non-specific brachial plexus tumor.
MRI revealed spinal cord compression and injury.
MRI showed strokes in @number@ ( @number@ % ) and moderate-to-severe WMH in @number@ ( @number@ % ) cases.
MRI site qualification and MP-RAGE quality assessment was applied following the NA-ADNI procedures.
MRI-visible perivascular space severity in either location did not predict PiB-PET.
MRI was performed in the dominant knees of subjects without knee pain and in the more symptomatic knees of subjects with knee pain.
MRI was performed within @number@ months of lumbar puncture.
MRI with DWI and ADC should be included in sCJD diagnostic criteria.
MRI with or without diffusion-weighted sequences remains the gold standard.
Mr K is an 89-year-old married man with a number of comorbid conditions and multiple recent falls.
MR measurements were performed on a @number@.0-Tesla clinical MRI scanner.
MR-pro-ADM levels were assessed in @number@ individuals who underwent evaluation of carotid intima-media thickness and arterial rigidity ( reflection index and stiffness index ) .
MRS measurements were performed at multiple TEs.
MRS showed good reproducibility at all sites in subjects with CKD and controls , with a coefficient of reproducibilities ranging from @number@ to @number@ %.
MRS studies have seldom been performed in the hippocampus due to technical challenges.
MRS studies in SCN1A-related diseases have reported striking differences in the mI concentrations between patients and controls.
MS4A6A transcripts were widely expressed in tissues and cells , with the exception of V4-MS4A6A , which was not expressed in neuronal cells.
MSA may have a CSF environment particularly favorable for fαS formation.
MSA was measured by self-reported frequency of six common MSA.
MS-based analytical approaches have been used to gain insight into the tau lysine-directed PTM signature that is most closely associated with neurofibrillary lesion formation.
MS-based lipid analysis of Pld2 mutant brains in the presence or absence of the SwAPP transgene unmasks striking crosstalks between different PA species.
MSC capability to differentiate into many cell types makes them a starting point of many new therapies , especially in tissue engineering.
MSC decreased non-significantly.
MSC of the 5th passage were selected as control group , and MSC of the 13th passage were taken as senile group.
MSCs are also used as a platform for gene therapies and therapeutic agents.
MSCs come from the surrounding tissues and / or circulation.
MSCs cultured on these surfaces exhibit improved proliferation capacity , maintenance of phenotype , and increased differentiation potential.
MSCs expand rapidly in vitro and have a potential for multilineage differentiation.
MSCs from aged donors that fail to differentiate in pellet culture are successfully induced to synthesize cartilage-specific matrix in EMTs under identical media conditions.
MSCs have been investigated for the treatment of many musculoskeletal disorders , including osteoarthritis and osteoporosis.
MSCs ( Mesenchymal stem cells ) can infiltrate into tumor tissue and function as the efficient transgene delivery mediator.
MSCs secrete large amounts of STC1 in response to TGF-β1 in comparison to AECs and fibroblasts.
MSCs were isolated from young and old rabbit bone marrow , muscle , and adipose tissue.
MSC treatment demonstrates improved functional outcomes that are encouraging for future translational studies.
MSC treatment produced better organ regeneration than chondrocyte treatment.
MSDK increased serum P1NP levels and reduced bone turnover ( CTx : P1NP ) .
M shows steady growth until BA @number@ in girls and BA @number@ in boys and then grows smaller in both.
MS improved with multidisciplinary treatment and exercise interventions in this population.
MSL and GS gave no significant training effect , whereas CT did show a significant training effect ( p < @number@ ) .
MSM provides more realistic estimates of treatment effects than the IPW approach for time-independent treatment.
Ms. Nagata talked about the human resources development of nurse responsible for tuberculosis care.
MsrA and MsrB activities decrease during aging , leading to accumulation of protein-based and free amino acid forms of methionine sulfoxide.
MsrA is required for lens cell maintenance , defense against oxidative stress damage , mitochondrial function and prevention of lens cataract formation.
Msrs repair oxidatively damaged proteins , protect against oxidative stress , and regulate protein function , and have also been implicated in the aging process.
MS significantly increased in the groups with high hs-CRP in comparison with pilots with intermediate hs-CRP levels and with those with low hs-CRP levels.
MS was also diagnosed by Chinese Diabetes Society ( CDS ) criterion.
MS was defined according to ATP III criteria.
MS was diagnosed by the consensus criterion released in @number@ from a joint collaboration between American Heart Association and other organizations.
MS was not associated with IDS sum score.
MS was quantified using a hand dynamometer.
MT10109L provides greater convenience because it does not require dilution and has long-lasting effects.
Mt activates telomerase.
MT also protects against development of obesity in mice provided a high fat diet as well as diet-induced oxidative stress damage.
MTA offers a promising new approach for the identification of drug targets in metabolically related disorders.
MTA Plus showed least values of continuous margins.
MTA scores showed a good correspondence with manual hippocampal volumes.
MtDNA mutations are one of the hallmarks of ageing and age-related diseases.
MtDNA was highly stable with low analytical variability.
MTDSA was highly associated with the outer diameter of the ETT ( r = @number@ R ( @number@ ) = @number@ ) .
MTG showed a significant increase in strength for dorsiflexion at 60° / s.
MT has demonstrated benefit throughout mild-severe stages of dementia.
MT has not been extensively investigated within the context of aging biology.
MTHFR gene encodes MethyleneTetraHydroFolate Reductase , a regulatory enzyme whose polymorphisms are associated with hyperhomocysteinemia.
MTH was measured using B-mode ultrasound at two sites on the anterior ( A50 ) and posterior ( P50 ) aspects of the mid-thigh.
Mt inhibits carcinogenesis and is active at systemic , tissue , cellular and subcellular levels.
MT is associated with changes in bleeding pattern and hormone profiles.
MT is one of just a handful of proteins that , when overexpressed , has been demonstrated to increase mouse lifespan.
Mt is shown to influence practically all organ systems by inhibiting mutagenesis and maintaining correlation between circadian rhythms of different biological processes throughout human evolution.
MTL is thus a biomarker of age.
MTL showed significant variation within age groups ( 4-11 kb ) in both the exposed and non-exposed groups.
MT may improve symptoms of depression and increase HRV in demented patients.
MTORC1 inhibition is an important step in autophagy activation.
MTRs were computed for @number@ areas in each hemisphere.
MTs are down-regulated in homozygous weaver ( wv / wv ) mice exhibiting progressive neurodegeneration , early aging , morbidity , and mortality.
MTs are induced in aging brain as a defensive mechanism to attenuate oxidative and nitrative stress implicated in broadly classified neurodegenerative α-synucleinopathies.
MT's mode of delivery is essential to the evidencebased use of music interventions and delivery methods.
MTT assay in three-time points @number@ @number@ and 72h after LNA-anti-miR-182 transfection was performed.
MT-training improves performance on untrained MT tasks and alters the functional activity of the brain during MT.
MTT value of elderly donor cells was significantly lower than those of young adult donors from day @number@ ( P < @number@ ) .
Mt was shown to protect from cardiac lesions associated with ischemia and reperfusion.
MUAC was interpreted according to National Health Statistics percentile.
Much attention has been given to this contentious topic for potential mothers , with many programs putting age-related limitations in place for their female patients.
Much developmental work has to be done about testosterone for women's health.
Much effort is needed to understand the benefits and limitations of such devices on people with hearing loss.
Much experimental evidence in vitro has shown the potential deleterious effects of carbamylated proteins on cell and tissue functions.
Much greater soft-tissue volume was present between the bilateral medial crura.
Much has been published on how this expansion disrupts neuronal homeostasis and how gene-based therapy might be an effective treatment in the future.
Much has been written about the effects of aging on reproductive function , especially female fertility.
Much is known in regards to how the face loses volume as the soft tissue structures age.
Much less is known about deficits in higher level form vision.
Much less is known about how aging may affect the contractility of the smooth muscle within the uterus , the myometrium.
Much less is known about how spatial abilities from nonvisual inputs , particularly from haptic information , may change during life-span spatial development.
Much less is known about the prevalence of skin cancer prevention messages in these magazines.
Much like other markers of brain disease , the association between WMH and cognition is imperfect.
Muchmore research is necessary to reveal the possibilities of induced effects in those fields.
Much of it can be prevented , however.
Much of our daily communication occurs in the presence of background noise , compromising our ability to hear.
Much of the above has been concerned with changes to bladder function and morphology.
Much of the evidence originates from in vitro and in vivo studies with cells , rodents , and nonhuman primates.
Much of the extant cortisol awakening response ( CAR ) literature posits that CAR is an anticipatory response to perceived demands later that same day.
Much of the research is descriptive and focused on needs assessments.
Much of the variance remained to be explained.
Much of the work on resveratrol and cancer comes from in vitro studies looking at resveratrol actions on cancer cells and pathways.
Much of what we currently know about T2D and AD is derived from in vivo and in vitro studies.
Much remains to be learned in this area , but cellular distribution within the cardiovascular system is becoming clearer.
Much remains unknown about hippocampal sclerosis associated with ageing.
Much research has centered on this particular histone modification and histone-modifying enzyme.
Much research has focused on understanding exactly how the brain changes as a function of experience.
Much work has focused on stem cell identification and the molecular pathways involved in their regulation.
Much work has shown age-related structural changes of the basal ganglia.
Much work lies ahead for validating the biomarker diagnosis of AD dementia.
Much work remains to be completed in this area and is facilitated by the growing base of knowledge regarding the pathophysiology of post-transplant diabetes.
Mucin @number@ ( MUC1 ) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling.
Mucociliary function was evaluated with saccharin test.
Mucormycosis diagnosis was based on several combinations of methods ; culture combined with histology was performed in @number@ cases ( @number@ % ) .
Mucosal-associated invariant T ( MAIT ) cells have been reported to play an antimicrobial role in infectious diseases.
Mulitvariable logistic regression was used to test the factors related to alcohol consumption.
Müller cells play a pivotal role in maintaining retinal homeostasis of the extracellular fluid environment.
Multicellular organisms rely upon diverse and complex intercellular communications networks for a myriad of physiological processes.
Multicompartment compliance aids ( MCAs ) have been advocated as a solution for this problem.
Multicomponent foods and natural ingredients have diverse effects produced by the actions of individual components as well as the interactions among different components.
Multicomponent instruments that measure different frailty domains seemed to outperform single-component ones.
Multi-covariate adjusted cross-sectional analyses indicated that higher selenium level was associated with higher blood pressure measures at baseline and higher rates of hypertension.
Multidetector CT ( MDCT ) gastrography has been regarded as a promising technique for the preoperative imaging of gastric cancer.
Multidisciplinary approach for proximal femoral fracture was organized in the hospital.
Multidisciplinary approach is paramount for proper treatment of this disease.
Multidisciplinary approach is warranted to value the balance between the therapeutic objectives and the patient quality of life.
Multidisciplinary approach with the aim of long-term health protection and prolongation of dancing careers is required in future studies.
Multidisciplinary assessment of health problems and disabilities is necessary to compose a comprehensive intervention program.
Multidisciplinary care , including early orthogeriatric input , is recommended to anticipate and treat complications.
Multidisciplinary evaluation and comprehensive geriatric assessment has gained importance regarding the treatment selection especially for definitive anti-cancer therapy recently.
Multidisciplinary hospital-based quality initiatives , disease management , and care transition programs are a priority for health care systems to achieve better coordination.
Multidisciplinary orthogeriatric care can enhance prompt ED diagnosis , optimal pre- and postoperative care , and functional recovery in older adults with bony injuries.
Multi-disciplinary teams are required to assess driving ability in patients with PD and develop rehabilitation measures for safer driving.
Multi-epitope specificity long-term after infection was lost in older age groups.
Multi-factorial assessment and active participation in an evidence-based exercise programme are key interventions to prevent and manage falls.
Multifactorial fall-prevention programmes are often not effective in preventing falls and functional decline.
Multifactorial intervention may also be useful in a hospital and residential care home setting.
Multifinger synergies were quantified using the framework of the uncontrolled manifold hypothesis.
Multifocal glasses can add to this risk by impairing contrast sensitivity , depth perception , and ability to negotiate obstacles.
Multiglandular disease was found to be more prevalent in older patients , but minimally invasive parathyroidectomy can be performed safely.
Multi-indicator methods may be more valid , but have not been studied in relation to VCI.
Multilevel analyses showed that social engagement and depressive symptoms correlated moderately on the level of the units.
Multilevel analyses were used to model the change in SRTn over time.
Multilevel backward regression analyses were performed.
Multilevel generalized linear regression was used.
Multilevel linear regression models assessed associations between CD4 count / VL and each of the outcomes.
Multilevel linear regression models were fitted with minutes walked and minutes cycled as dependent variables and the weather variables as independent variables.
Multilevel linear regression was used to estimate associations between healthy food availability and BMI.
Multilevel logistic regression analysis was performed to obtain odds ratios ( ORs ) and @percent@ confidence intervals ( CIs ) .
Multilevel logistic regression models assessed the impact of disability and selected social determinants of health on readmission beyond current risk adjustment.
Multilevel logistic regression stratified by gender and a three-step mediation analysis procedure were used.
Multilevel logistic regression was used and proportional changes in Intraclass Correlation Coefficient ( ICC ) were inspected to assert explained variance between models.
Multilevel modeling , adjusting for demographics / health / training group , was used to determine the trajectories of OTDL performance.
Multilevel modeling and generalized estimating equations modeled the continuous relationships between age and each dependent variable.
Multilevel modeling results indicate that driving cessation reduced husbands ' productive and social engagement , and wives ' productive engagement.
Multilevel modeling revealed that the computer group rated memory and concentration as having improved at @number@ months and again at @number@ months.
Multilevel modeling techniques were used to test whether age moderated both the within- and between-person associations.
Multilevel modeling was used to determine prevalence ratios for the association between walkability and obesity.
Multilevel modeling was used to test for additive and multiplicative complexity effects in local and global switch costs.
Multilevel modeling was used to test for changes over time in HIV-related symptom clusters.
Multilevel modeling with an R program was used to test models accounting for hot flush severity.
Multilevel modelling compared rates of decline after effects of sex , demographics , and practice were taken into consideration.
Multilevel models assessed the level of discrepancies between dyadic members and examined predictors accounting for the discrepancies.
Multilevel models evaluated within-person associations of daily experiences with sleep quality and duration.
Multilevel models showed the patterns of daily time use did not differ by caregiver types.
Multilevel models were employed to estimate emotional reactivity coefficients , which were subsequently entered into a Cox proportional hazards model to predict mortality.
Multilevel models with common within-person variance were fit first to show average associations between daily stressors and mean level of daily affect.
Multilevel multinomial logistic modeling was used to analyze the risk factors and changes of undermet needs over time.
Multilevel multinomial logit models estimated the odds of abstinence and heavy drinking relative to moderate drinking.
Multilevel multivariate logistic regression determined predictors of depression and depression screening.
Multi-level regressions and survival analyses for hazard ratio ( HR ) were used for analyses.
Multimodal interventions that could target these prioritized determinants were also suggested.
Multimodal neuronavigation allows the integration of preoperative anatomic and functional data with intraoperative information.
Multimodal therapies are often necessary and the principles are presented.
Multimodal treatment strategy is based on a combination of surgical debridement of necrotic bone and cartilage and systemically active antifungal treatment.
Multimorbidity and polypharmacy , together with alterations in pharmacokinetics and pharmacodynamics , make older people at risk of adverse medication reactions.
Multimorbidity considerations should be a priority in the development of future health policies focused on quality of life and disability.
Multimorbidity has been defined as two or more chronic conditions.
Multimorbidity is associated with adverse health outcomes , but limited research has been undertaken in LMICs.
Multimorbidity is defined as the presence of two or more chronic diseases at age @number@ years.
Multimorbidity is highly prevalent in older adults with ID.
Multimorbidity may be related to the supposed early aging of people with intellectual disabilities ( ID ) .
Multimorbidity patterns were defined as combinations of two or three of @number@ specific chronic conditions in the same individual.
Multimorbidity should receive more attention in research and clinical practice for targeted pro-active prevention and treatment.
Multimorbidity was also associated with reporting a larger increase in these subjective memory complaints during the past year.
Multimorbidity was assessed as number of chronic diseases.
Multi-morbidity was classified as the presence of two or more non-infectious comorbidities.
Multimorbidity was defined as a patient having been diagnosed with two or more of @number@ chronic diseases in the general practitioner's electronic medical records system.
Multimorbidity was prevalent in @percent@ and associated with age and severe / profound ID.
Multi-motor unit activity was recorded intramuscularly from the first dorsal interosseus muscle.
Multinomial logistic Markov models estimated disability transition probabilities adjusted for age , sex , race / ethnicity , education , and the health factors.
Multinomial logistic regression analysis ( crude and adjusted ) was used.
Multinomial logistic regression analysis was performed with AUDIT categories as outcome , and demographic , social , somatic , and psychological variables as determinants.
Multinomial logistic regression examined interactions between urban-rural status and environments in associations with physical activity.
Multinomial logistic regression models examined the association between the frequency of using household sprays and disinfectants with asthma and wheezing adjusting for potential confounders.
Multinomial logistic regression models were used for the analyses , as death was treated as an alternative outcome.
Multinomial logistic regression models were used to assess the relationship , adjusting for potential confounders.
Multinomial logistic regression models were used to examine whether sleep duration predicted self-rated health and quality of life.
Multinomial logistic regression models with low frequency as the reference category were employed to identify REHAB risk factors associated with self-perceived uselessness.
Multinomial logistic regressions adjusted for potential confounders were used to assess the relationship between polyphenols and frailty.
Multinomial logistic regression showed that highly concerned women were significantly more likely to have poorer health and quality of life and lower functional ability.
Multinomial logistic regressions revealed socio-demographic characteristics among health classes.
Multinomial logistic regression tested the main and moderating roles of each domain on cognition categorized as no impairment , CIND , and dementia.
Multinomial logistic regression was adopted to explore the influencing factors of LTC needs.
Multinomial logistic regression was conducted to identify predictors of past-month high-risk alcohol consumption.
Multinomial logistic regression was used to identify factors associated with group membership.
Multinomial logistic regression was used to identify variables sensitive to discriminate between three frailty levels.
Multinomial Processing Tree ( MPT ) models are an effective way to estimate these conditional probabilities.
Multinomial regression analyses tested if higher autotaxin was associated with higher relative risk for MCI or AD diagnosis , compared to the CN group.
Multinomial regression analysis was used , with sexuality as outcome.
Multinomial regression associates risk factors with trajectory group membership.
Multinomial regression models assessed the associations stratified by sex and in additional analyses by midlife body mass index ( BMI ) .
Multiphoton imaging of ANS binding should be a useful probe for monitoring protein misfolding stress in cells.
Multiphoton tomography for in vivo high-resolution multidimensional imaging has been used in clinical investigations and small animal studies.
Multiple and linear regression of obtained morphometric parameters showed significant increase of glomerular connective tissue area and percentage.
Multiple and simple linear regressions were used to analyze the relationships between the variables.
Multiple arguments already exist against postmenopausal motherhood , most of which stress the potential risk of damage involved due to the mother's advanced age.
Multiple biological processes are related to cognitive impairment in older adults , but their combined impact on cognition in midlife is not known.
Multiple biomarkers of outcomes that demonstrate the same health benefit may also be helpful.
Multiple cancers increase with aging.
Multiple causes contribute to the prolonged reaction-times ( RT ) observed in elderly persons.
Multiple consistent networks have been found in large populations , and have been shown to be stable over time.
Multiple contributing factors , such as repetitive stress and structural changes in the foot , further compromise function.
Multiple Cox regression analysis was used to evaluate the associations of eGFR with all-cause mortality.
Multiple cytochrome P450s and carboxylesterase enzymes are responsible for human pyrethroid metabolism.
Multiple devices are available and are detailed later in the text.
Multiple excitability indices were measured in both motor and sensory axons from median and ulnar nerves.
Multiple extrastriatal regions also showed age-related declines.
Multiple extrinsic and intrinsic events that cause DNA instability are associated with aging.
Multiple factors are proposed to influence food intake , yet our understanding of these diverse factors and their interactions are limited.
Multiple factors have contributed to this improvement including safer anesthetic agents , better monitoring devices and the development of a specialized pediatric environment.
Multiple factors influence vesicular uptake and ALDH activity.
Multiple factors may cause nocturia , such as behavioral or environmental factors and pathologic conditions.
Multiple foci were detected in @percent@ of idiopathic patients.
Multiple focus group meetings and a Delphi procedure were organized to gain consensus on the Coach2Move strategy.
Multiple gene expression alterations have been linked to Alzheimer's disease ( AD ) , implicating multiple metabolic pathways in its pathogenesis.
Multiple-group analysis revealed that this model fit the data for all age groups.
Multiple group analysis was employed to examine the proposed model.
Multiple group modeling examined associations between training gains and locus of control across racial groups.
Multiple hierarchical regressions examined determinants of psychological distress within Pearlin's stress process model.
Multiple hierarchical regressions explored walking under dual-task conditions.
Multiple imputation methods were used to complete a data set missing age , sex or diagnosis data.
Multiple imputation ( MI ) was used to handle missing values with posterior inferences appropriately adjusted to account for between-imputation variability.
Multiple imputation techniques and sensitivity analyses were undertaken to investigate possible bias arising from sample attrition.
Multiple imputation was applied to handle the missing data ; missing data due to mortality were not imputed.
Multiple independent times smaller , shorter-lived species changed to having longer telomeres and expressing telomerase.
Multiple in-depth exploratory interviews were conducted with @number@ gay-identified men living with HIV / AIDS over an 18-month period.
Multiple interventions are now available to treat patients with diabetes.
Multiple levels of regulation impinge on STAR action.
Multiple linear and logistic regression models were conducted.
Multiple linear and logistic regression models were used to evaluate the association between APOE genotypes and cognition.
Multiple linear regression analyses indicated that the intervention group assignment ( EF ) was independently from other potentially related factors associated with less cognitive decline.
Multiple linear regression analyses were performed adjusting for age , gender , race , education , BMI , sleep apnea risk , and perceived stress.
Multiple linear regression analyses were performed to analyse associations of 25 ( OH ) D3 and iPTH with bone status parameters.
Multiple linear regression analyses were performed to evaluate the association of LTL with each SNP adjusted for age , gender and diabetes status.
Multiple linear regression analyses were used to examine the relationship between gait and mobility under single vs dual conditions.
Multiple linear regression analysis identified BMI and chronological age ( p < @number@ ) as significant predictors of lung age.
Multiple linear regression analysis indicated that systolic BP variability is correlated positively with carotid-femoral pulse wave velocity independent of HR variability.
Multiple linear regression analysis revealed that age and education significantly influenced performance on ECAS total score and sub-scale scores.
Multiple linear regression analysis showed that pack-years ( history of smoking ) were significantly associated with the Symbol Digit Substitution Test in men.
Multiple linear regression analysis showed that percentage fat mass was a significant negative decisive factor for BMD in premenopausal women.
Multiple linear regression analysis showed that these unique hypertensive features were significantly related to systolic blood pressure ( P < 0.05 ) .
Multiple linear regression analysis showed that the XI was independently associated with age and appetite.
Multiple linear regression analysis was performed to evaluate the relationships between theophylline clearance and the clinical characteristics of preterm infants.
Multiple linear regression analysis was performed with adjustment for confounders.
Multiple linear regression analysis was used to assess the association between andropause symptoms and depression.
Multiple linear regression analysis was used to calculate the impact exerted by seasonality and by influenza immunization coverage on hospitalization rates.
Multiple linear regression analysis was used to investigate the relationship between CRP and depressive symptoms.
Multiple linear regression analysis was used with adjustments for age , baseline body mass index , and other potential confounders.
Multiple linear regression and mediation analyses were performed.
Multiple linear regression and stratified analyses were used.
Multiple Linear Regression ( MLR ) models were applied to analyze the association between diet factors and iron biomarkers on TBARS and ORAC levels.
Multiple linear regression modeling was used to assess the effect of variable combinations of QEEG and other measures , including age and PD duration.
Multiple linear regression models adjusting for potential confounders were used to determine the association between accelerometer-measured physical activity and LTL.
Multiple linear regression models indicated that gender , age and BMI significantly affected length and girth parameters of foot together.
Multiple linear regression models ( partition / substitution ) to assess these associations were used.
Multiple linear regression models were employed to predict cognitive performance , adjusting for potential confounding factors.
Multiple linear regression models were then built to examine the independent effect of age and iron deposition on DTI metrics.
Multiple linear regression models were used.
Multiple linear regression models were used to analyze this association and interaction study.
Multiple linear regression models were used to assess the effect of independent variables on PCS-36 and the physical subscales of SF-36.
Multiple linear regression models were used to estimate associations between allostatic load scores and affective , somatic , and overall depressive symptoms.
Multiple linear regression models were used to test associations.
Multiple linear regressions showed that circadian rhythm disturbance was independently associated with increased lipid peroxidation in females with BD ( p < @number@ ) .
Multiple linear regressions were used to examine the correlations between the PCDBI and the severity of anosognosia.
Multiple linear regression was performed to identify independently associated factors with changes in each of the selected lipid fractions.
Multiple linear regression was used to evaluate the influence of social ties as the mediators and moderators on the relationship between widowhood and depressive symptoms.
Multiple lines of evidence suggest that Aβ oligomers are more toxic than other peptide forms.
Multiple lines of evidence suggest that plasticity declines throughout the age-span and may underlie age-related cognitive decline.
Multiple logistic regression analyses identified independent predictors related to advance directive completion.
Multiple logistic regression analyses were conducted to identify associations between loneliness and potential protecting resources.
Multiple logistic regression analyses were performed to find independent correlates of frailty among participants living alone.
Multiple logistic regression analyses were used to determine the risk factors for IPUs.
Multiple logistic regression analyses were used to investigate the association between various sociodemographic variables and hardcore smoking.
Multiple logistic regression analysis confirmed ageing as an independent factor related to negative attitude in all scenarios.
Multiple logistic regression analysis identified male gender and better cognitive function as consistent determinants of physical independence across all age categories.
Multiple logistic regression analysis revealed moderate and severe ED to be risk factors for depression.
Multiple logistic regression analysis showed that body mass index was independently associated with the response to PR.
Multiple logistic regression analysis showed that Letter Fluency , Boston Naming Test and delayed memory recall remained independent predictors of FTLD compared to AD.
Multiple logistic regression analysis was conducted and age in 50s , two-shift work , sleep , night snacking and exercise were significantly associated with GHQ12.
Multiple logistic regression analysis was performed after adjustments for sex , age , and conventional cardiovascular risk factors.
Multiple logistic regression analysis was performed on associations of lumbar motion range among the SN population.
Multiple logistic regression analysis was performed to analyze the association.
Multiple logistic regression analysis was then performed.
Multiple logistic regression analysis was used to analyse the influence of family member support on physical and psychological health.
Multiple logistic regression analysis was used to assess factors associated with fear of falling and fear-induced activity restriction.
Multiple logistic regression and paired t tests were conducted to compare health outcomes across occupations and within individuals over time.
Multiple logistic regression models were created.
Multiple logistic regression models were used to assess the association between tobacco smoke exposure and overweight.
Multiple logistic regressions showed that severe family dysfunction was a risk factor for cognitive impairment.
Multiple logistic regression was used for analysis.
Multiple logistic regression was used to compare several variables between undiagnosed and diagnosed hypertension , and between uncontrolled and controlled hypertension.
Multiple logistic regression was used to develop the algorithm , and the regression coefficient-based scores were used to determine individual risks.
Multiple logistic regression was used to estimate the association between gender-specific sleep duration and hypertension prevalence.
Multiple loss-of-function mutations in TRIAD3 ( a.k.a.
Multiple markers in this region showed evidence for association with CBE , including @number@ markers with genome-wide significance.
Multiple measures are used to define and predict functional decline.
Multiple mechanisms are involved , including changes in protease levels.
Multiple mediation analysis revealed that participation in the intergenerational program was associated with a sense of manageability which was also significantly related to depressive mood.
Multiple medications also contribute to delirium , another multifactorial syndrome resulting in excess mortality particularly in frail older people.
Multiple methods have been proposed by the community to extract robust disease specific markers from various imaging modalities.
Multiple mice were constructed from each cord blood donor.
Multiple models have been proposed to explain the Ant1-induced pathogenesis.
Multiple mutations in the neurofilament light polypeptide gene , NEFL , cause CMT2E.
Multiple myeloma ( MM ) is a plasma cell neoplasm with a chronic disease course that primarily affects elderly individuals.
Multiple neurocognitive subsystems are involved in resolving lexical ambiguity under different circumstances.
Multiple options , especially high-dose tinidazole , have been used for metronidazole-resistant trichomoniasis.
Multiple ordinary least square ( OLS ) , logistic , and zero-inflated Poisson regression models were conducted in the main analysis.
Multiple-oscillator circadian mechanisms are likely to play a role in regulating human health and may contribute to the aging process.
Multiple points of potential therapeutic intervention are discussed.
Multiple population studies have reported a positive correlation between higher levels of physical activity ( PA ) and longer lifespan.
Multiple potentially modifiable cardiovascular and lifestyle risk factors have been associated with this disease.
Multiple protein models were built using stepwise regression techniques and support vectors machines.
Multiple regression analyses also showed that age was the best predictor of current pain intensity in healthy controls but not in individuals with CP.
Multiple regression analyses revealed a significant effect of age and education , but not gender , for both UDs and CSs.
Multiple regression analyses revealed that in younger adults both spatial and temporal context retrieval performance was predicted by anterior HC volume.
Multiple regression analyses showed that coagulation and fibrinolysis markers were not significantly associated with HADS anxiety and depression scores.
Multiple regression analyses were conducted.
Multiple regression analyses were conducted.
Multiple regression analyses were conducted to examine the moderating role of CGG-repeat length on the relation between age and postural sway under dual-task interference.
Multiple regression analyses were performed , adjusting for sociodemographic and health status variables.
Multiple regression analyses were performed controlling for gender and exact age at scanning.
Multiple regression analyses were used to evaluate whether discrimination was independently associated with LTL.
Multiple regression analyses with interaction effects revealed that streamline counts between left and right mid-dlPFC were negatively associated with planning performance specifically in early postadolescence.
Multiple regression analysis confirmed the independent association between LnNT-proBNP and GFR.
Multiple regression analysis did not show any significant relation between changes in testosterone concentrations and change in cognitive function scores.
Multiple regression analysis displayed that the TC level of LG reversely associated with BDNF Val66Met genotype.
Multiple regression analysis indicated that the value of VO ( 2peak ) was independently correlated with carotid IMT , lumen diameter and wall mass.
Multiple regression analysis revealed that greater PA was associated with a shorter time to complete the Trail-making test , and higher levels of verbal fluency.
Multiple regression analysis revealed that serum T was an independent predictor of both QUS at the calcaneus and phalangeal pBMD.
Multiple regression analysis showed that beside fascicular size , age more significantly predict perineurial collagen type IV content.
Multiple regression analysis showed that HOMA-IR was an independent factor influencing serum betatrophin levels.
Multiple regression analysis showed that participants ' education , age and gender accounted for 10-32% of the variance in factor scores.
Multiple regression analysis was also used to investigate the correlation between these covariates and physical function tests results.
Multiple regression analysis was applied to derive sex-specific estimation formulae using bioelectrical impedance analysis , and a Bland-Altman analysis was used to test agreement.
Multiple regression analysis was performed.
Multiple regression analysis was performed to examine the association between social network types and mental health.
Multiple regression analysis was performed to examine the relationship of BMD with LM , FM and %BF.
Multiple regression analysis was performed to investigate the independent effect of each factor associated with a slower usual gait speed.
Multiple regression analysis was performed to understand the interactions of gender , height and age.
Multiple regression analysis was used to adjust for chronologic age ( CA ) .
Multiple regression analyzes were performed to identify factors predictive of long-term outcomes.
Multiple regression and correlation analyses were applied to investigate the mediation effect of standard measures of cognition on the observed effects of age on FDM.
Multiple regression and factor analysis investigated whether body parts nearby in S1 were significantly correlated.
Multiple regression models were applied to determine associations between retinal vascular Df and general cognitive ability ( g ) , processing speed , and memory.
Multiple regression models were employed to determine whether received support , anticipated support , and negative interaction influence older parents ' well-being.
Multiple regression models were used to assess the presence of sleep , MTL , or regional cortical differences between groups.
Multiple regression models with robust ( White-corrected ) standard errors were individually fitted for nutrients and foods by living situation.
Multiple regression of ACR against age , status , ALT , CRP , and Globulins confirmed many significant interactions.
Multiple regression techniques were used to analyze the data.
Multiple regression was used in a whole-brain analysis with age , APOE group , and their interaction predicting functional brain modulation in response to difficulty.
Multiple regression was used to develop prediction equations for determining relative muscle content of MHC types I , IIa , and IIx.
Multiple regression was used to study the influence of demographic-clinical variables on hippocampal volume.
Multiple reports have offered information regarding the pending shortage and made recommendations regarding interventions.
Multiple risk factors were also calculated by summing all these risk factors.
Multiple sclerosis is among the most serious inflammatory demyelinating diseases ( IDD ) .
Multiple sclerosis ( MS ) is a chronic autoimmune disease , and the most common cause of nontraumatic disability in young people.
Multiple sclerosis ( MS ) is an autoimmune demyelinating disease of the central nervous system with an increasing incidence in females.
Multiple sclerosis ( MS ) is an inflammatory autoimmune disease of the central nervous system ( CNS ) involving demyelinating and neurodegenerative processes.
Multiple sclerosis ( MS ) is an inflammatory demyelinating disease of the central nervous system.
Multiple sclerosis should be included in differential diagnosis of disorders with ADA elevation in the CSF.
Multiple somatic gene therapy approaches are being developed for LHON which are applicable to other mtDNA diseases.
Multiple sources of data ( interviews , documents , reports , surveys ) from each site informed the analysis.
Multiple statistical models were used to adjust for demographic and biological covariates.
Multiple stepwise linear regression analysis was used to identify significant determinants of lumbar extensor muscle strength.
Multiple studies have demonstrated that telomere length predicts mortality and that telomeres shorten with age.
Multiple studies have found neurofunctional changes in normal aging in a context of selective attention.
Multiple studies have indicated a strong correlation between these two diseases.
Multiple studies have investigated the possible underlying mechanisms of age-related decline in kidney function.
Multiple studies have reported the benefits of cosmetic make-up.
Multiple studies have yielded new insights regarding initial management , with regards to both treatment and strategies of care.
Multiple studies investigating AMD with the use of animal models and cell culture have identified oxidative stress-related retinal damage as an important contributing factor.
Multiple studies suggest that the bony aging of the orbit and midface is a process primarily of contraction and morphologic change.
Multiple study methods were adopted.
Multiple sub-themes were also identified.
Multiple system atrophy is a fatal sporadic adult-onset neurodegenerative disorder with no symptomatic or disease-modifying treatment available.
Multiple-system atrophy ( MSA ) is a fatal neurodegenerative disorder with unknown etiology.
Multiple system atrophy ( MSA ) is a fatal oligodendrogliopathy characterized by prominent α-synuclein inclusions resulting in a neuronal multisystem degeneration.
Multiple therapeutic interventions designed to reverse these pathways are now being tested in the clinic.
Multiple thioether modifications of Ser and Thr residues by glutathione ( GSH ) and its metabolites were unambiguously identified.
Multiple trajectories of multimorbidity show the patterns of health burden and risks to successful aging among the elderly over time.
Multiple trauma in the elderly is increasing with the aging population.
Multiple types of anti-aging treatments are required to address the various etiologies of facial aging.
Multiple within-session acquisitions provide extremely high contrast to noise , making the data amenable to a wide range of analytic approaches including automated computational analysis.
Multiplex methylation SNaPshot reactions were used to generate the data.
Multiplicative censoring , renewal processes , deconvolution and decreasing density : non-parametric estimation.
Multipolar pacing was an independent predictor of all these events.
Multipotency was also examined using lineage-specific stains and spectrophotometry of metabolites.
Multipotent human bone marrow stromal cells ( hBMSCs ) potentially serve as a source for cell-based therapy in regenerative medicine.
Multisectoral action theories form the basis for the second example on Venezuela's revolutionary national Barrio Adentro health improvement program.
Multishell dMRI and MET2 data were acquired from @number@ healthy participants aged 17-70 years.
Multi-task balance training likely results in reduced attention demand.
Multi-task exercises ( like dancing ) might be a powerful tool to improve motor-cognitive dual-task performance.
Multitasking ( MT ) constitutes engaging in two or more cognitive activities at the same time.
Multitasking negatively influences the retention of information over brief periods of time.
Multivariable-adjusted Cox regression analysis examined the relationship between ALM and mortality.
Multivariable-adjusted logistic and Poisson regression models were used to examine the relationship between dietary GL and MMSE score.
Multivariable adjusted odds ratios ( ORs ) and hazard ratios ( HRs ) were calculated and effect modification by age and BMI was studied.
Multi-variable adjusted regression analyses were performed to assess the associations of baseline retinal vascular parameters and prevalent and incident ESRD.
Multivariable-adjusted stepwise regression was used to develop a metabolite predictor set representative of muscle CSA and the FFMI.
Multivariable analyses demonstrated an increase in BDI scores with increased aging.
Multivariable analyses explored the effect of gender and other predictors of tissue outcome on percentage mismatch lost.
Multivariable analyses showed that those seen by either an endocrinologist or urologist were more likely to receive appropriate tests.
Multivariable analyses were performed using SAS.
Multivariable analysis demonstrated statistically significant increases in hazard ratio ( HR ) after age @number@ when compared to ages 1-64.
Multivariable analysis identified direct association with age and inverse association with health self-rated.
Multivariable analysis of the differences in medical expenditure among PISA quartiles was carried out using linear regression with robust standard errors.
Multivariable analysis showed that baseline National Institutes of Health Stroke Score was associated with favorable outcome ( p = 0.026 ) in young adults.
Multivariable analysis to correct for possible confounders and propensity score that matched the minimize selection bias were utilized.
Multivariable analysis was conducted to determine factors associated with HCC diagnosis within groups.
Multivariable analysis was used to analyse associations between baseline activity and outcomes at follow-up controlling for socioeconomic , demographic and health-related variables at baseline.
Multivariable and propensity models adjusted for confounding.
Multivariable conditional logistic regressions were used to estimate the association between use of dopamine agonists and heart failure.
Multivariable conditional logistic regression was used to estimate adjusted odds ratios ( aOR ) and @percent@ confidence intervals ( CIs ) .
Multivariable Cox proportional hazards models were used to identify predictors of hospitalization.
Multivariable Cox proportional hazards regression models with attained age as time scale were fitted to estimate mortality rate ratios.
Multivariable Cox regression models were used to estimate associations between the computed score , its components , and subcomponents in relation to obesity-related cancer risk.
Multivariable Cox regression was used to estimate hazard ratios and @percent@ confidence intervals ( CIs ) for the association of aPWA with AF.
Multivariable generalized estimating equations were used , adjusting for demographic characteristics , health-related behaviors , health status , and access to health care.
Multivariable linear and Cox regression were used to assess associations with metabolic risk factors and incident diabetes , respectively.
Multivariable linear and logistic regressions were adopted to assess the adjusted association between cognitive performance and LVEF.
Multivariable linear and logistic regression were used to assess associations between HIV status and RNFL / CS and frailty.
Multivariable linear regression analyses indicated that one interquartile range difference in PFOS corresponded to @percent@ and @percent@ increases in fT4 and T4 respectively.
Multivariable linear regression analyses were performed to identify factors associated with severity of menopause symptoms.
Multivariable linear regression analysis was used to evaluate associations between thyroid hormones and sums of POPs , adjusted for covariates and stratified by sex.
Multivariable linear regression assessed predictors of well-being including medical , physical , cognitive , psychological , and environmental factors.
Multivariable linear regression evaluated the association between the groups and measures of nutritional parameters.
Multivariable linear regression evaluated the association between the groups and measures of physical function.
Multivariable linear regression models compared hormone values between tertiles adjusting for race , age , and menopausal status.
Multivariable linear regression models were used to assess cohort differences in P62 and P65 while adjusting for covariates.
Multivariable linear regression models were used to estimate the association between CVH and log-transformed LTL.
Multivariable linear regression models were used to test the association between function and cognition in race- and sex-specific groups after adjusting for covariates.
Multivariable linear regression models were utilised to test the associations.
Multivariable linear regression of all surgical and demographic factors versus PSQI was performed and demonstrated that preoperative and prolonged postoperative narcotic use negatively affected sleep.
Multivariable linear regressions were conducted to assess associations between PFASs and neuropsychological test scores.
Multivariable linear regression was used to determine associations between trajectories and relative change in lean mass and physical function.
Multivariable linear regression was used to estimate the adjusted mean difference of insulin secretion and sensitivity across the same 25OHD tertiles.
Multivariable linear regression was used to evaluate the association between EF impairment and performance on the TUG and grip strength.
Multivariable logistic and Cox regression analyses were performed to determine the independent effects of early obesity on risk for HCC and patient outcomes , respectively.
Multivariable logistic and linear regression analyses were performed to assess the associations.
Multivariable logistic models were used to determine factors associated with 3-month PSCI.
Multivariable logistic regression analyses were performed to evaluate the relationships between these diseases and frailty.
Multivariable logistic regression analyses were used.
Multivariable logistic regression analyses were used to explore risk factors.
Multivariable logistic-regression analysis evaluated the predictors of perioperative morbidity and mortality.
Multivariable logistic regression analysis was used to assess the association between BMI and back pain.
Multivariable logistic regression analysis was used to estimate the odds ratios of experiencing perceived age discrimination in relation to selected sociodemographic factors.
Multivariable logistic regression and Cox proportional hazards were used to analyze the relationship between pain and 5-year mortality.
Multivariable logistic regression evaluated frailty risk factors.
Multivariable logistic regression evaluated risk factors for being in the OS group.
Multivariable logistic regression involving @number@ preoperative patient-level risk factors and comorbidities was used to calculate the conditional probability of having IS.
Multivariable logistic regression models for PCa risk of absolute levels ( one-time measure and 5-year average ) and annual change in testosterone were respectively constructed.
Multivariable logistic regression models separately assessed the relationships between baseline PF and 2-year WL and WG ≥ @percent@.
Multivariable logistic regression models were used to test associations among the @number@ forms of cerebrovascular disease and the presence of ischemic and neurodegenerative brain lesions.
Multivariable logistic regression model was performed to find the variables possibly associated with exposure of E. granulosus infection in yaks , Tibetan pigs and Tibetan.
Multivariable logistic regressions were used to evaluate whether cancer was independently associated with geriatric syndromes.
Multivariable logistic regression was carried out to analyze the determinants for use of \ "never appropriate \ " medications.
Multivariable logistic regression was undertaken to identify variables independently associated with beliefs and knowledge.
Multivariable logistic regression was used to adjust for confounding and selection bias.
Multivariable logistic regression was used to assess the association between social relationships and depression , anxiety , and suicidal ideation.
Multivariable logistic regression was used to assess the independent contributions of multiple demographic and clinical covariates in predicting the binary outcome , HIV infection.
Multivariable logistic regression was used to calculate Odds Ratios ( OR ) and their @percent@ Confidence Intervals ( @percent@ CI ) .
Multivariable logistic regression was used to evaluate the relationship between CFS or FI-lab and outcomes.
Multivariable logistic regression was used to explore associations between specific self-restrictions and age group , adjusting for other personal characteristics.
Multivariable logistic regression was used to identify factors associated with in-hospital adverse events ( complications or mortality ) .
Multivariable logistic regression was used to verify the association between clusters and outcomes ( in-hospital mortality and 3-month postdischarge mortality and rehospitalization ) .
Multivariable , mixed-effects models were used to identify associated participant and hospital characteristics , examine trends over time , and characterize hospital-level variation.
Multivariable models adjusted for demographics , traditional CVD risk factors , and eGFR.
Multivariable models tested whether race / ethnicity , income , or genetic ancestry predicted annualized %ΔBMD after controlling for an extensive set of covariates.
Multivariable models were constructed using two machine learning methods , namely lasso penalized regressions and random forests.
Multivariable multilevel logistic regression was performed , controlling for personal socio-demographic and health characteristics and geographical area remoteness and socio-economic status.
Multivariable negative binomial regression adjusted for confounders were undertaken.
Multivariable ordered polytomous logistic regression was used to determine the association between FIB-4 status and acetaminophen exposure stratified by HCV status.
Multivariable Poisson regression with a sandwich variance estimator was used to evaluate associations between HDL particle components and embryo quality , adjusted for covariates.
Multivariable regression analyses examined whether activities performed by caregivers and supports for caregivers were associated with these burden scales.
Multivariable regression analyses revealed that aging , increased renal expression of p16 and decreased expression of Klotho were independently correlated with interstitial fibrosis.
Multivariable regression analyses were conducted to examine the associations between protein intake and BMD and BMC.
Multivariable regression analyses were performed , adjusting for traditional risk factors and left ventricular structure.
Multivariable regression identified associated factors.
Multivariable regression models identified factors associated with shortened aTL.
Multivariable regression models were used to assess the independent effect and covariate-adjusted contribution of the factors.
Multivariable techniques were used to assess the effects of older age on operative outcome measures , adjusting for covariates.
Multivariate adjusted analysis was performed comparing cognitive scores by OH status overall and in SH and non-SH groups separately.
Multivariate-adjusted hazard risk ( HR ) and @percent@ confidence intervals ( CI95% ) were estimated using Cox proportional hazards regression.
Multivariate adjustment including rate of cognitive decline during the first decade of FU did not change these relationships.
Multivariate adjustment only slightly modified the 25 ( OH ) D-mortality association.
Multivariate analyses confirm the importance of caregiver , not patient , characteristics for burden and self-esteem.
Multivariate analyses revealed that activity participation yielded stronger positive associations with word recall and self-rated memory than social network alone.
Multivariate analyses revealed that carotid-femoral PWV and aortic AIx were strongly influenced by central PP but not by the mean blood pressure or brachial PP.
Multivariate analyses revealed that female sex and severe impairment in daily activity functioning were independently associated with depressive disorders.
Multivariate analyses were conducted to evaluate potential correlates of the lithium dose-concentration ratio.
Multivariate analyses were done for each structural measure with scores of processing speed , executive function , and memory as dependent variables.
Multivariate analyses were used to determine factors associated with odds of developing these surgical complications.
Multivariate analyses were used to investigate the impact of aging in wound dehiscence.
Multivariate analyses were used to model in-hospital mortality , new nursing home placement , and length of stay.
Multivariate analysis after omitting the confounding role of age revealed a higher grade of hepatosteatosis in female patients ( P = @number@ ) .
Multivariate analysis did not attenuate this finding ( OR = @number@ @percent@ CI @number@.61-0.90 ) .
Multivariate analysis identified independent risk factors for OS.
Multivariate analysis identified older age as an independent prognostic factor for DSS in the overall group.
Multivariate analysis including demographic characteristics revealed that when adjusted for age and body weight , BAC positivity was a significant risk factor for breast cancer.
Multivariate analysis indicated that age , RLD , ECG conduction defects , Holter arrhythmia and LVEF remained independent predictors.
Multivariate analysis indicated that a high UBCR was positively associated with aging , hypertension , macroalbuminuria and increased urinary sodium excretion.
Multivariate analysis indicated that both ANP and BNP levels were influenced by age , hemoglobin level , and platelet counts.
Multivariate analysis indicated that TMZ was a significant factor for PFS.
Multivariate analysis of covariance ( MANCOVA ) assessed changes in BC in quitters vs. continued smokers between baseline and @number@ months of follow-up.
Multivariate analysis revealed age ≥80 years , higher ASA status and emergency operations as independent risk factors for increased in-hospital mortality.
Multivariate analysis revealed an association between death and time elapsed from symptom onset.
Multivariate analysis revealed that age and baseline hepatitis B surface antigen ( HBsAg ) levels independently predicted post-treatment HBV relapse.
Multivariate analysis revealed that individuals ≥ @number@ years of age responded significantly less well to vaccination than younger adults.
Multivariate analysis revealed that the only independent prognostic risk factor for AF recurrence after CA is age.
Multivariate analysis revealed that the TT median value of < 4.0 ng / mL was the only significant marker for the detection of MetS.
Multivariate analysis showed that a MNA score < 12 was independently associated with SOP compared to normal when adjusted for age and gender.
Multivariate analysis showed that generalised and abdominal obesity was independently associated with risk of hypertension , diabetes and arthritis in both men and women.
Multivariate analysis showed that HIV duration was an independent predictor of several comorbidities , whereas nT was protective for cancer and COPD.
Multivariate analysis showed that increased CD66b + TIN was an independent prognostic factor for overall survival ( p = @number@ ) .
Multivariate analysis showed that not being on benefits was the variable most consistently associated with better quality of life , as was being partnered.
Multivariate analysis showed β-amyloid imaging as the single variable most strongly associated with progression.
Multivariate analysis shows a higher OR of corneal blindness in subjects age @number@ and older ( @number@ ) and male gender ( @number@ ) .
Multivariate analysis was performed to identify independent prognostic factors associated with cancer-specific survival.
Multivariate analysis was performed using analysis of covariance , with covariates mainly including socio-demographic , lifestyle-related and health-related factors.
Multivariate analysis with generalized estimating equation ( GEE ) model was performed to exclude confounding factors.
Multivariate and univariate statistical analyses were done to determine association of age with urinary chemokines in OAB patients.
Multivariate binomial logistic regression analysis was performed on @number@ participants with complete data.
Multivariate comparisons were made between the @number@ age groups on the cancer-related concerns.
Multivariate Cox proportional hazard models were used to assess the contribution of age , sex , clinical measures , and treatments to ESRD and mortality.
Multivariate Cox proportional hazards models were used to analyze the data.
Multivariate Cox regression analysis also demonstrated that the age of the patient was not an independent factor for the prognosis of CRC.
Multivariate Cox regression was used to assess the association of depression and telomere length to outcomes and the joint effect of both.
Multivariate generalized linear models were used to assess the associations.
Multivariate general linear models for multiple memory outcomes were used to test hypotheses controlling for potential confounders.
Multivariate growth curve models were applied to examine the dimensionality of individual differences in longitudinal changes.
Multivariate hazard analysis revealed a significant correlation between high @date@ immunoreactivity and poor cancer-specific survival ( p = @number@ ) .
Multivariate hierarchical regression analysis showed that the SMA self-efficacy , partner status , and self-esteem were determinants of loneliness.
Multivariate Imputation by Chained Equations ( MICE ) , Generalized Additive Models ( GAMs ) and mixed effect Cox models were used.
Multivariate linear and logistic regression were used to model the association between change in olfactory performance and demographic , health , and psychosocial factors.
Multivariate linear regression analyses adjusted for age , current smoking and current hormonal contraceptive use were performed on log-transformed serum AMH levels.
Multivariate linear regression analyses were constructed to examine the association between the total MeDi score and cognitive functioning and brain volumes.
Multivariate linear regression analyses were used to evaluate independent determinants.
Multivariate linear regression analysis controlling for potential confounders was performed to compare cognitive function by syncope and falls status.
Multivariate linear regression analysis was performed to assess their relationship with measures of adiposity.
Multivariate linear regression models or analyses of covariance were also performed.
Multivariate linear regression models were used to estimate associations of smoking habits with baseline LTL and changes in LTL over time.
Multivariate linear regression was performed to calculate unstandardized regression coefficients and P values for trends across tertiles of FAs are reported.
Multivariate linear regression was used to model the association between cognition and different quintiles of each HRV index , after adjustment for covariates.
Multivariate linear regression was used to predict change in pure tone average.
Multivariate linear regression was used to test independent effects of the covariates.
Multivariate logistic regression analyses using nested models were conducted separately for males and females.
Multivariate logistic regression analyses were used to identify correlates.
Multivariate logistic regression analysis identified the PET score as the most significant predictive factor distinguishing AD converters from non-converters.
Multivariate logistic regression analysis revealed that BMI , hypertension , and smoking were independent determinants of a high-baPWV subject.
Multivariate logistic regression analysis was conducted to identify independent predictors.
Multi-variate logistic regression analysis was performed to identify independent driving ability clinical predictors.
Multivariate logistic regression and Cox proportional hazards models were used , adjusting for potential confounders.
Multivariate logistic regression and receiver operating characteristic ( ROC ) analyses were performed.
Multivariate logistic regression examined the risk of cognitive impairment with adjustment for potential confounders.
Multivariate logistic regression models examine the demographic and economic situations of both older and younger cohorts that encourage or constrain intergenerational exchanges.
Multivariate logistic regression models were applied in order to identify factors associated with undernutrition in populations with or without dementia.
Multivariate logistic regression models were developed to identify generational differences.
Multivariate logistic regression models were used in the analysis.
Multivariate logistic regression models were used to develop and validate a risk scoring tool for each outcome.
Multivariate logistic regression models were used to estimate the association between job strain and T2DM.
Multivariate logistic regression models were used to evaluate age and gender-related differences in fatal intersection crash risk , controlling for covariates.
Multivariate logistic regression models were used to examine the associations between demographic and caregiving variables with caregiver involvement in three medication management activities.
Multivariate logistic regression models were used to identify individual factors associated with the use of potentially inappropriate drugs.
Multivariate logistic regression model was applied to examine the association between number of teeth missing and cognitive function.
Multivariate logistic regression revealed that HHIE scores were associated with the extent of HA usage.
Multivariate logistic regression showed a high SAPS II score and age ≥70yo as independent risk factors for DWLSTs in the ICU.
Multivariate logistic regressions were conducted to examine BE attributes both separately and conjointly.
Multivariate logistic regressions were used to examine all associations.
Multivariate logistic regression was completed with dietitian consult ≤ @number@ days and @number@ + days as the outcome variables.
Multivariate logistic regression was conducted to analyze factors associated with measure disagreement.
Multivariate logistic regression was conducted to determine predictors of chronic smoking behavior which was operationalized as meeting criteria for LDCT screening.
Multivariate logistic regression was performed.
Multivariate logistic regression was used for analysis.
Multivariate logistic regression was used to assess predicators of SA among those aged 65 + and having complete data on cognition.
Multivariate logistic regression was used to assess the associations after adjustment to potential confounders.
Multivariate logistic regression was used to identify risk factors for a complicated course.
Multivariate logistic regression was used to identify risk factors for PIM prescription.
Multivariate logistic regression was used to identify significant relationships , while adjusting for potential confounders.
Multivariate logistic regression was used to investigate the associations between UR and a number of covariates.
Multivariate mixed effects logistic regression controlling for potential confounding variables was applied to account for clustering effects of study sites.
Multivariate modeling showed that mother's longevity and offspring's grip strength operated through the same or overlapping pathway to longevity.
Multivariate models are estimated for physical disability and wealth.
Multivariate models for the outcomes , adjusting for characteristics of the caregiver / noncaregiver and care-recipient / potential care recipient , were run.
Multivariate modified Poisson regressions were used to estimate the associations between vision , activity limitations , and social participation restrictions.
Multivariate one-sided hypotheses testing problems arise frequently in practice.
Multivariate ordinal regressions were computed to assess the relative contribution of the health determinants on the FI quartiles in each age group.
Multivariate pattern analysis and statistical machine learning techniques are attracting increasing interest from the neuroimaging community.
Multivariate regression ( accounting for age and gender ) was used to assess relationships between optic nerve head measures and visual function.
Multivariate regression analyses were conducted with interpersonal content variables predicting BP and distress.
Multivariate regression analysis revealed that the MT and EI of the knee extensor muscle were independently associated with maximum isometric knee extension strength.
Multivariate regression analysis showed that age and duration of dialysis were independent variables for sarcopenic status.
Multivariate regression analysis showed that age , waist circumference and blood glucose level were the positive factors for DeltaSBP.
Multivariate regression analysis showed that aging , increased HbA1c and CRP levels , and prevalent CHD were independently associated with masked hypertension.
Multivariate regression analysis stratified by gender and electrocardiographic lead location was used to determine independent predictors of maximum JPA.
Multivariate regression analysis was conducted to examine associations between the identified social network types and self-rated health and depression.
Multivariate regression analysis was performed to determine the risk factors and health impact associated with the burden of geriatric conditions.
Multivariate regression model methodology was used to test associations longitudinally.
Multivariate regressions showed greater alcohol problem severity in males compared to females , but no significant differences between Blacks and Whites.
Multivariate regression techniques were employed to examine the influence of relative income on accessibility for @number@ persons aged @number@ and over.
Multivariate regression was used to adjust for age , gender , race , mechanism of injury , and Injury Severity Score.
Multivariate repeated-measures generalized linear models estimated mean number of teeth with moderate-to-severe disease at each examination by coffee intake level.
Multivariate results supported genetic and environmental differences in attachment.
Multivesicular bodies ( MVBs ) are intracellular endosomal organelles characterized by multiple internal vesicles that are enclosed within a single outer membrane.
Multivitamin supplementation may be necessary , even in healthy individuals , to ensure an adequate micronutrient intake in the elderly.
Mulvihill-Smith syndrome is a rare progeria-like disorder with characteristic findings including premature aging , short stature , pointed face and multiple melanocytic nevi.
Murine Aβ codeposits and colocalizes with human Aβ in amyloid plaques , and the two Aβ species coimmunoprecipitate together from brain extracts.
Murine IGFBP-3 was similar in all mouse genotypes and decreased with age in parallel with total IGF-1.
Murine tumors lacking Sirt3 exhibit abnormally high levels of ROS that directly induce genomic instability and increase hypoxia-inducible factor 1α ( HIF-1α ) protein levels.
Muscarinic acetylcholine receptors ( mAChRs ) mediate acetylcholine-induced neurotransmission and five mAChR subtypes ( M1-M5 ) have been identified.
Muscarinic receptor density was assessed autoradiographically using the non-selective radioligand [ ( @number@ ) H ] quinuclidinylbenzilate.
Muscle activation increased peak force , but this force was distributed over a larger area , preventing increased localized loading over the greater trochanter.
Muscle activation time @number@ ) following stimulus onset ( PMAT ) and @number@ ) before movement onset ( MAT ) was calculated.
Muscle adaptations can be induced by high-resistance exercise.
Muscle and coordination training are recommended to the patients as general measures.
Muscle architecture is an important component to typical musculoskeletal models.
Muscle area and intermuscular adipose tissue were assessed with computed tomography.
Muscle area and TUG did not differ between fallers and non-fallers.
Muscle biopsies from the vastus lateralis were obtained before and @number@ hours after exercise.
Muscle biopsies of @number@ older , mobility-limited adults were obtained at baseline.
Muscle biopsies ( vastus lateralis ) were obtained at rest and @number@ @number@ and @number@ h after exercise.
Muscle biopsies were obtained at baseline and @number@ weeks after vitamin D3 supplementation ( @number@ IU / day ) in older adults.
Muscle biopsies were obtained before and after the diet , immediately after exercise , and after 3-h recovery.
Muscle biopsies were obtained from the m. deltoid and vastus lateralis.
Muscle biopsies were performed after @number@ wk of training.
Muscle biopsies were taken at rest and @number@ @number@ and @number@ h following leg press and knee extension exercise.
Muscle biopsies were taken from the nonexercised and exercised vastus lateralis at @number@ @number@ and @number@ h postexercise.
Muscle biopsies were used to evaluate respiratory capacity ( high resolution respirometry ) and oxidant emissions ( spectrofluorometry ) in isolated mitochondria.
Muscle biopsy , performed in @number@ patients , showed neurogenic changes and normal nuclear staining with anti-matrin @number@ antibody.
Muscle co-activation of the trunk showed a significant positive correlation with gait speed based on age.
Muscle coactivation remained unaltered in both groups.
Muscle co-activation was significantly correlated with gait speed by aging.
Muscle contraction timings were designated as premotor time , electromechanical delay and total reaction time.
Muscle cross-sectional area ( CSA ) was obtained from computed tomography scans at the mid-thigh.
Muscle cross-sectional area ( mCSA ) of the left leg was assessed by peripheral quantitative computed tomography.
Muscle CSA declined after immobilization in the Plc but not in the GH group.
Muscle CSA increased during retraining , with a significantly larger increase in the GH group compared with the Plc group.
Muscle CSA was derived from proton density images.
Muscle density correlated with fat density in both controls and GO patients.
Muscle depletion in cachexia is associated with increased protein breakdown , mainly involving the pathways dependent on ubiquitin-proteasome and autophagy-lysosomes.
Muscle dysfunction engenders numerous diseases , including diabetes , cachexia , and sarcopenia.
Muscle EMG responses differed most in the period following support surface tilt indicating that muscle activity increased to support stabilization against the visual flow.
Muscle fatigue of the erector spinae was assessed using electromyography.
Muscle fiber membranes separate the intracellular components from the extracellular environment and consist of lipid bilayers which act as an electrical capacitor.
Muscle force values from upper limb muscles were measured using the MicroFet @number@ hand-held dynamometer.
Muscle function decline is a commonly observed process that occurs with aging.
Muscle function improved in the entire cohort with no difference between the groups.
Muscle function in the lower extremities was measured using a leg extension power ( LEP ) rig in the ageing participants.
Muscle function on a cellular level in the aging population is less efficient.
Muscle function was assessed by means of walking-speed test , standing balance , and sit-to-stand tests.
Muscle IGF1Ea mRNA expression correlated positively with collagen I mRNA expression ( P < 0.01 ) .
Muscle is characterized by wide plasticity , i.e. capacity to adjust size and functional properties in response to endogenous and exogenous influences.
Muscle is hyper-elastic , but also viscoelastic.
Muscle loss is a typical process of aging.
Muscle loss occurs as a consequence of several chronic diseases ( cachexia ) and normal aging ( sarcopenia ) .
Muscle loss shows stronger associations with unfavorable outcomes than fat loss.
Muscle mass and gait speed were additionally measured after @number@ years.
Muscle mass measures were similar across HbA1c quartiles.
Muscle mass recovery following immobilisation-induced atrophy could be critical , particularly when it is uncompleted as observed during ageing.
Muscle mass was assessed by height-adjusted appendicular skeleton muscle mass ( aASM ) in kg / m2 , as measured by dual-energy x-ray absorptiometry.
Muscle mass was estimated by calf circumference ( CC ) and mid-arm muscle circumference ( MAMC ) of the dominant side.
Muscle mass was estimated by using mid-arm muscle circumference ( MAMC ) and calf circumference of the dominant side.
Muscle mass was examined by dual-energy X-ray absorptiometry and physical performance was assessed by hand-grip strength , gait speed , step length and chair-stand test.
Muscle mass was measured by DXA.
Muscle mass was relatively preserved in comparison with grip strength and gait speed.
Muscle measures were standardized and analyzed in multivariate linear regression models , stratified by age.
Muscle mechanoreflex activation appears to play a predominant role in causing renal vasoconstriction , both in isolation and in the presence of local metabolites.
Muscle morphogenesis transforms short muscle precursor cells into long , multinucleate myotubes that anchor to tendons via the myotendinous junction.
Muscle mTORC1 signaling was assessed by immunoblotting.
Muscle Nerve 56 : 1001-1005 , @number@
Muscle Nerve 56 : 399-407 , @number@
Muscle Nerve 56 : 982-986 , @number@
Muscle Nerve 57 : E52-E59 , @number@
Muscle parameters were assessed at baseline and after a median of @number@ y.
Muscle power at 180° / s , isometric maximal torque , and maximal contraction velocity at @percent@ 1RM were measured during unilateral leg extension.
Muscle power was measured using a power rig.
Muscle protein metabolism is a dynamic process characterized by the balance between the synthesis and breakdown of muscle proteins.
Muscle protein synthesis ( MPS ) increased @percent@ while muscle protein breakdown ( MPB ) decreased @percent@ , respectively.
Muscle protein turnover following resistance exercise and amino acid availability are relatively well described.
Muscle qualitative features are described from the perspective of how physical exercise may improve muscle quality in older adults.
Muscle quality was calculated as muscle strength divided by leg lean mass.
Muscle quality was defined as knee extensor strength / leg lean mass.
Muscle quality was defined by the ratio between muscle strength ( kgf ) and muscle mass ( kg ) .
Muscle represents a large fraction of the human body mass.
Muscle represents an abundant , accessible , and replenishable source of adult stem cells.
Muscle samples of the vastus lateralis were collected before and during a 3-hour @number@ mU / m ( @number@ ) / min clamp.
Muscle samples were collected from @number@ young and @number@ old males.
Muscles from transgenic animals did not display protein aggregates or structural abnormalities at the light or transmission electron microscopic levels.
Muscles of old laboratory rodents experience exaggerated force losses after eccentric contractile activity.
Muscle-specific depletion of TRAF6 preserves skeletal muscle mass in a mouse model of cancer cachexia or denervation.
Muscle strength and function were assessed through handgrip strength testing and repeated chair stand test , respectively.
Muscle strength and muscle performance were evaluated according to grip strength and the modified short physical performance battery ( SPPBm ) .
Muscle strength by grip strength using a hand-held dynamometer and muscle mass was measured by bioimpedentiometer.
Muscle strength declined significantly after @number@ years of age , both in men and women ( P < @number@ ) .
Muscle strengthening , balance training and traditional Chinese Tai Chi reduce the risk of falls in the elderly.
Muscle strength , including leg strength and respiratory muscle strength , are relatively independently associated with mobility disability in elders.
Muscle strength is important in functional activities of daily living and the prevention of common pathologies.
Muscle strength ( muscle torque / body mass ) was significantly greater for all TS components in @percent@ MVC contractions.
Muscle strength of upper and lower extremities was assessed through handgrip strength testing and repeated chair stand test , respectively.
Muscle strength showed significant correlation with walking speed in both men and women in both age groups.
Muscle strength's mean was @number@ ( IQR : @number@ @number@ ) kg , with significantly higher values among men.
Muscle strength was assessed by hand grip strength , knee extension strength , and peak expiratory flow.
Muscle strength was assessed via isokinetic quadriceps strength ( IQS ) in newton as measured by a dynamometer.
Muscle strength was determined with dynamometer.
Muscle strength was examined with a hand-held dynamometer in ER and IR.
Muscle strength was not associated with any of the measured muscle metabolites or markers of OS.
Muscle sympathetic nerve activity bursts were abolished by trimethaphan within minutes.
Muscle sympathetic nerve activity ( MSNA ) was measured using microneurography.
Muscle-tendon forces were estimated by using the inverse-dynamic based static optimization where cost functions were tuned to capture the different muscle co-activation between groups.
Muscle thickness was also compared among the regions.
Muscle tissue is vascularized by an elaborate vascular network.
Muscle training with NMES reduces the degradation process.
Muscle ultrastructure was evaluated using EM morphometry.
Muscle vasodilatory response was analyzed by repeated-measures analysis of variance followed by Tukey's post hoc test.
Muscle wasting and decreased function of skeletal muscle are important factors in many age-related morbidities.
Muscle-wasting stimuli upregulate the expression , as well as the auto-ubiquitination , of TRAF6 leading to downstream activation of major catabolic pathways in skeletal muscle.
Muscle weakness and atrophy in the quadriceps , wrist flexor , and finger flexors are the typical clinical findings in sIBM.
Muscle weakness and atrophy in the quadriceps , wrist flexor and finger flexors are the typical neurological findings of sIBM.
Muscle weakness and sensory disturbance were also observed.
Muscle weakness associated with aging implicates central neural degeneration.
Muscle weight and bone mineral density were significantly decreased in aged Tg mice relative to control WT and IL-13 KO Tg mice.
Muscular factors ( dynamometer ) and speed of information processing parameters ( computer-based reaction time task ) were determined.
Muscular power was determined by knee extension with @number@ % of 1RM and countermovement jump ( CMJ ) .
Muscular strength was found to increase most consistently compared with results from traditional resistance exercise.
Muscular strength was measured with handgrip strength.
Musculoskeletal disorders had considerable impact on the use of primary and specialist health services in Norway.
Musculoskeletal metabolic diseases such as osteoporosis have become the major public health problems worldwide in our aging society.
Musculoskeletal pain , but not mental distress , was prospectively associated with overall SA during pregnancy in the adjusted individual-level analyses.
Musculoskeletal pain was assessed as reported pain in back , hips or knees when moving or resting.
Musculoskeletal problems are the most frequently reported complaints among older adults living in the community.
Musculo-skeletal symptoms like pain were reported by @percent@ , @percent@ had depressive symptoms and @percent@ general fatigue.
Musculoskeletal tests assessed muscle strength , balance and mobility.
Musculoskeletal ultrasound was used for accurate needle placement for the aspiration of SF followed by subsequent PRP injections.
MusEQ scores showed a significant positive relationship to independent ratings of music engagement.
MusEQ scores were moderately correlated with a global rating of ' musicality ' and with music education.
Music , arts-based , and narrative programs were most common.
Music has implications for well-being and for therapy , notably for individuals living with dementia.
Musicianship in early life is associated with pervasive changes in brain function and enhanced speech-language skills.
Musicians provide an attractive model for studying the experience-dependency of auditory processing in humans due to their distinctive neural enhancements compared to nonmusicians.
Music intervention , yoga , and combined relaxation training most effectively reduced anxiety symptoms among older adults.
Music is a complex acoustic signal that relies on a number of different brain and cognitive processes to create the sensation of hearing.
Music is an important resource for achieving psychological , cognitive , and social goals in the field of dementia.
Music is a non-invasive , simple and inexpensive therapeutic method of improving quality of life in community-dwelling elders.
Music is a way of expressing our feelings and emotions.
Music therapy was effective when patients received interactive therapy with a compared group.
Mussel bioactive peptides have been viewed as mediators to maximize the high quality of life.
Mussel oligopeptides also led to the increase of glutathione ( GSH ) level and mitochondrial transmembrane potential ( Δψm ) recovery.
Mustard gas exposure was found to transform the age scale for developing lung cancer.
Mutagen.
Mutagenesis-based experiments show that this interaction requires a D-Box found within the FBG1 F-box domain.
Mutant fibroblasts furthermore exhibited an altered response during recovery from drug-induced disruption of the actin cytoskeleton.
Mutant frequency arising from mtDNA base substitutions that confer erythromycin resistance and deletions between 21-nucleotide direct repeats was determined.
Mutant FUS selectively accumulates into discrete cytosolic structures known as stress granules under various stress conditions.
Mutant N-terminal huntingtin ( Htt ) protein resulting from Huntington's disease ( HD ) with expanded polyglutamine accumulates and forms aggregates in vulnerable neurons.
Mutants in these pathways either delay or accelerate the development of late life diseases giving rise to extended healthy lives or progerias , respectively.
Mutant sir2Δ shows a series of different phenotypes , all dependent on the deacetylase activity of Sir2p.
Mutant variants of the mtDNA polymerase cause mutagenesis that contributes to aging , genetic diseases , and sensitivity to environmental agents.
Mutated ATXN3 alleles consensually present about @number@ to @number@ CAG repeats , resulting in an expanded polyglutamine tract in ataxin-3.
Mutational analyses of MATR3 were carried out by direct nucleotide sequencing in a cohort of @number@ unrelated patients with ALS.
Mutational screening of the mitochondrial 12S rRNA gene identified @number@ nucleotide changes , including @number@ mutations localized at highly conserved sites and @number@ known variants.
Mutational status was correlated with biological parameters.
Mutation analysis in the gene encoding fibrillin @number@ ( FBN1 ) revealed a novel de novo heterozygous deletion , c.8155 8156del2 in exon @number@
Mutation analysis of known CL genes was negative.
Mutation analysis of PYCR1 revealed a novel single-base deletion ( c.345delC ) in exon @number@ leading to frame-shift and premature stop of translation.
Mutation carriers did not show significantly different voxelwise fMRI activity from noncarriers as a group.
Mutation detection kits were used to detect heteroplasmic mtDNA mutation.
Mutation in the CAXII gene causes cystic fibrosis-like syndrome and salt wasting disease.
Mutation in the WRN protein leads to the premature aging disease Werner syndrome , a disorder that features neurodegeneration.
Mutation of both target sites eliminated this effect.
Mutation of Janus-Kinase @number@ ( JAK2 ) is the most frequent genetic event detected in Philadelphia-negative MPN.
Mutation of Ser-46 to alanine prevents the phosphorylation , ubiquitination , and degradation.
Mutation of specific stretches of basic amino acid residues abolished the TGN-localization of SMAP2.
Mutations affecting the expression of key genes involved in the control of bone development occur in several heritable bone disorders.
Mutations in all genes linked to Parkinson's disease lead to enhanced sensitivity to mitochondrial toxins and oxidative stress.
Mutations in a number of genes including SOD1 and FUS are associated with familial ALS.
Mutations in APTX cause an inherited human disease syndrome characterized by early-onset progressive ataxia with ocular motor apraxia ( AOA1 ) .
Mutations in A-type nuclear lamins cause laminopathies.
Mutations in CHCHD10 have recently been described as a cause of frontotemporal dementia ( FTD ) comorbid with amyotrophic lateral sclerosis ( ALS ) .
Mutations in COL18A1 are known to cause Knobloch syndrome ( KS ) .
Mutations in common causative FTD genes are not a major cause of familial and sporadic FTD in the Southern Italian population.
Mutations in common causative FTD genes ( GRN , MAPT , VCP , and TARDBP ) and C9ORF72 expansions were screened.
Mutations in DJ-1 are associated with autosomal recessive early-onset PD.
Mutations in DNAJC13 , DNAJC6 and DNAJC5 have been implicated in Parkinson's disease ( PD ) .
Mutations in FBXO7 ( PARK15 ) have been associated with a syndrome characterized by early-onset progressive parkinsonism with and without pyramidal tract signs.
Mutations in human CISD2 cause type @number@ Wolfram syndrome , a rare neurodegenerative and metabolic disorder associated with a shortened lifespan.
Mutations in human lamins cause over @number@ different diseases , termed laminopathies.
Mutations in human mitochondrial DNA ( mtDNA ) can cause mitochondrial disease and have been associated with neurodegenerative disorders , cancer , diabetes and aging.
Mutations in IFT genes lead to ciliary structural defects and systemic disorders termed ciliopathies.
Mutations in IKKβ at Lys171 , identified in Multiple Myeloma and other cancers , lead to a dramatic increase in kinase activation and K63-linked ubiquitination.
Mutations in lamins are also associated with the metabolic syndrome ( MS ) .
Mutations in lamins cause > 14 distinct diseases , called laminopathies , that include heart , muscle , fat and early aging diseases.
Mutations in lamins impair lamina functions and cause a set of highly tissue-specific diseases collectively referred to as laminopathies.
Mutations in leucine-rich repeat kinase @number@ ( LRRK2 ) contribute to both idiopathic and familial forms of PD.
Mutations in LMNA gene cause a class of pathologies generically named ' Lamanopathies ' mainly involving heart and skeletal muscles.
Mutations in LRRK2 ( leucine-rich repeat kinase @number@ ) are the most common cause of familial PD ( Parkinson's disease ) .
Mutations in mitochondrial acylglycerol kinase ( AGK ) cause Sengers syndrome , which is characterized by cataracts , hypertrophic cardiomyopathy , and skeletal myopathy.
Mutations in mtDNA lead to muscular and neurological diseases and are linked to aging.
Mutations in Nesprins have been identified in a group of human diseases that have been summarized as laminopathies.
Mutations in @number@ genes have been shown to cause this phenotype.
Mutations in PINK1 and PARK2 , as well as PARK7 / DJ-1 , underlie autosomal recessive Parkinsonism and impair mitochondrial function and morphology.
Mutations in presenilin @number@ gene ( PS1 ) account for the majority of early-onset familial Alzheimer's disease ( FAD ) cases.
Mutations in several genes encoding nuclear envelope ( NE ) associated proteins cause Emery-Dreifuss muscular dystrophy ( EDMD ) .
Mutations in SNCA are rare causes of familial Parkinson's disease ( PD ) .
Mutations in SOX5 have been previously found in patients with amyotrophic lateral sclerosis ( ALS ) and developmental delay , intellectual disability and dysmorphic features.
Mutations in SPARTAN are associated with early onset hepatocellular carcinoma and progeroid features.
Mutations in superoxide dismutase ( SOD1 ) are associated with familial ALS and lead to SOD1 protein misfolding and aggregation.
Mutations in TAR DNA-binding protein @number@ ( TDP-43 ) are associated with familial forms of amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Mutations in TDP-43 cause amyotrophic lateral sclerosis ( ALS ) , a fatal paralytic disease characterized by degeneration and premature death of motor neurons.
Mutations in telomerase component genes in the disease dyskeratosis congenita result in numerous epidermal abnormalities.
Mutations in the CNGB3 gene account for > 50% of all known cases of achromatopsia.
Mutations in the colony-stimulating factor @number@ receptor ( CSF1R ) gene have recently been identified in HDLS patients.
Mutations in the gene encoding tau ( MAPT ) cause frontotemporal dementia spectrum disorders.
Mutations in the gene p62 / SQSTM1 have been reported as a relatively rare cause of frontotemporal lobar degeneration ( FTLD ) .
Mutations in the glucocerebrosidase ( GBA ) gene are a strong genetic risk factor for the development of Parkinson's disease and dementia with Lewy Bodies.
Mutations in the glycosylation pathway lead to a phenotypically heterogeneous group of metabolic disorders , the congenital disorders of glycosylation ( CDG ) .
Mutations in the GRN gene resulting in partial loss of the encoded PGRN protein cause frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions.
Mutations in the matrilin-3 VWA domain cause various skeletal diseases.
Mutations in the MBL2 gene can significantly change the serum level of MBL , and consequently alter the susceptibility and progression of infectious disease.
Mutations in the moesin gene in humans are associated with primary immunodeficiency with profound lymphopenia , and moesin-deficient mice exhibit a similar lymphopenia phenotype.
Mutations in the nuclear encoded genes that disrupt mitochondrial functions are also discussed.
Mutations in the optineurin ( OPTN ) gene cause amyotrophic lateral sclerosis ( ALS ) .
Mutations in the OPTN gene are well known to be associated with the development of glaucoma.
Mutations in the p62 PB1 domain that abolish self-oligomerization also abolished crosslinked oligomer formation.
Mutations in the parkin , PINK1 and DJ-1 genes all result in recessive parkinsonism.
Mutations in the Presenilin-1 ( PSEN1 ) gene are the major cause of familial Alzheimer's disease ( FAD ) .
Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer.
Mutations in these genes have been associated to transient or permanent CH , with a high intra and interfamilial phenotypic variability.
Mutations in the WRN gene can be of several types , including nonsense mutations , leading to a truncated protein form.
Mutations in this protein causing muscular dystrophies can now be rationalized.
Mutations in TMEM230 have recently been associated to Parkinson's disease ( PD ) .
Mutations in TREM2 and TYROBP genes are known to cause NHD.
Mutations in TYROBP and TREM2 have been shown to cause polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy.
Mutations in UBQLN2 are therefore not a frequent cause of ALS in the Irish population.
Mutations in UBQLN2 have been shown to be a cause of dominant X-linked amyotrophic lateral sclerosis ( ALS ) .
Mutations in VPS35 ( PARK17 ) cause autosomal dominant , late onset Parkinson's disease ( PD ) .
Mutations in WRN are responsible for the disease and cause telomere dysfunction , resulting in accelerated aging.
Mutations of Cu-Zn superoxide dismutase ( SOD1 ) have rarely been identified in Chinese patients with amyotrophic lateral sclerosis ( ALS ) .
Mutations of human mitochondrial DNA ( mtDNA ) have also been identified in malignant tumors of the skin and of other organs.
Mutations of mtDNA cause a variety of human mitochondrial diseases and are also heavily implicated in age-associated disease and aging.
Mutations of the BLM gene can result in Bloom syndrome , an autosomal recessive disorder associated with cancer predisposition.
Mutations of the lamin A gene cause various premature aging syndromes , including Hutchinson-Gilford progeria syndrome ( HGPS ) and atypical Werner syndrome.
Mutations of the von Hippel-Lindau ( VHL ) tumor suppressor gene cause hereditary and sporadic renal cell carcinomas ( RCCs ) .
Mutations of this protein are linked to laminopathies and specifically to Hutchinson-Gilford Progeria Syndrome ( HGPS ) , an accelerated aging disease.
Mutations resulting in haploinsufficiency of progranulin ( PGRN ) cause frontotemporal lobar degeneration with TDP-43-positive inclusions ( FTLD-TDP ) , a devastating neurodegenerative disease.
Mutations that inhibit the insulin-like growth factor-1 ( IGF-1 ) extend the lifespan of worms , flies and mice.
Mutations to both GNE domains are linked to GNE myopathy.
Mutations were tested in HL-1-derived cells endogenously expressing NaV1.5 but made deficient in PKP2 ( PKP2-KD ) .
Mutation within ATEE selectively abolished α2M promoter activity in senescent ( but not young ) cells.
Mutual dependence between the x and y components of posturographic signals was analyzed using principal component analysis ( PCA ) .
MUTYH-associated polyposis ( MAP ) is an adenomatous polyposis transmitted in an autosomal-recessive pattern , involving biallelic inactivation of the MUTYH gene.
MVAA had the strongest inverse association with BW change ( @number@ kg , @percent@ CI @number@ @number@ ) .
MVBs were initially regarded as purely prelysosomal structures along the degradative endosomal pathway of internalized proteins.
MVC was evaluated at baseline , immediately after exercise , and @number@ min afterwards.
MVPA , was also associated with a reduced decline in cognitive ability ( rate ratio @number@ [ @number@.75-0.95 ] ) .
MVPA was also positively associated with physical function , after adjusting for SB , BST , and potential confounders.
MWSS is significantly higher in females than in males in all six neck vessels.
Myasthenia gravis ( MG ) is an autoimmune disease that affects the post-synaptic area of the neuromuscular junction.
MYBPC1 missense mutations are linked to the development of Distal Arthrogryposis-1 ( DA-1 ) .
Myc inactivation or pharmacological suppression of ER stress alleviates fatty liver caused by SIRT7 deficiency.
MYC is a potent oncogene involved in ∼70% of human cancers , inducing tumorigenesis with high penetrance and short latency in experimental transgenic models.
Mycobacterium tuberculosis continues to be a major threat.
Myc oncoproteins induce genes driving aerobic glycolysis , including lactate dehydrogenase-A that generates lactate.
My discussion focuses on @number@ main issues.
Myelin-associated neurite outgrowth inhibitor ( Nogo ) -a and its receptor , NgR1 , limit recovery of the adult central nervous system after injury.
Myelination and iron deposition in the brain evolve both spatially and temporally.
Myelin enriched in lipids is easily oxidized by reactive oxygen species during inflammation.
Myelin impairments have been suggested to lead to neuronal dysfunction and cognitive decline.
Myelin pallor was evident in the posterior and lateral columns of the spinal cord.
Myelin thus seems to serve as a provider of substrates and signals for axons , and not as a mere insulator.
Myeloablation of tumor-bearing hosts mostly abolished IL-27's antitumor effects.
Myelodysplastic syndrome ( MDS ) is an age-associated hematopoietic malignancy , characterized by abnormal blood cell maturation and a high propensity for leukemic transformation.
Myelodysplastic syndromes ( MDS ) are a group of myeloid stem cell clonal disorders characterized by a wide variation in illness trajectory and potential treatment.
Myeloid malignancies often arise from an aging hematopoietic system and are currently incurable due to therapy-resistant , disease-reinitiating leukemic stem cells.
Myelomeningocele in the offspring was confirmed by a pediatrician with expertise in classifying neural tube defects.
My entry into the role of lecturer-practitioner , on a two-year contract , coincided with this exciting and challenging time for health visiting in Hackney.
My findings may aid health and mental health care providers in the management and treatment of patients seen in settings with limited resources.
My goal is to provide a biomechanical framework for this discussion.
My life was thrust into a paradox : My relationship was defined by a world that refused to recognize it.
Myoablation was found to be useful in ameliorating noticeable frown wrinkles caused by muscular hyperactivity.
Myocardial aging is characterized by left ventricular ( LV ) fibrosis leading to diastolic and systolic dysfunction.
Myocardial blood flow ( MBF ) was measured by using ( @number@ ) O-water positron emission tomography ( PET ) .
Myocardial diastolic velocity E ' implies that age is the most important determinant.
Myocardial fat accumulation could occur in diseased hearts.
Myocardial hypoenhancement was observed in @number@ patients ( @percent@ ) .
Myocardial ischemia followed by ischemia / reperfusion ( I / R ) induces irreversible damage to cardiac muscle.
Myocardial perfusion deficits at scintigraphy are neither obligatory nor specific.
Myocardial T2 values were analysed globally and according to the @number@ segment model.
Myocilin accumulation is observed in approximately 70-80% of all glaucoma cases suggesting that environmental or other genetic factors may also promote myocilin toxicity.
Myofiber and SC characteristics were determined from muscle biopsies of the vastus lateralis using immunohistochemistry.
Myofibrillar and collagen protein synthesis were unaffected by the local NSAID infusion.
Myofibrillar protein synthesis was unaffected by elevation of GH and IGF-I.
Myogenic progenitor cells that form skeletal muscles of the trunk and limbs are derived from the dermomyotome , the dorsal region of the somite.
Myo-inositol ( MI ) was elevated in the frontal white matter ( FWM , P = @number@ ) .
Myometrial tissue specimens were obtained at cesarean delivery from @number@ women with maternal ages ranging from @number@ to @number@ years.
Myopia , hyperopia and accommodation disorders are common refractive disorders , usually due to anatomical abnormalities or to physiological aging.
Myopia is absent in undisturbed hunter-gatherers but ubiquitous in modern populations.
Myosin heavy chain isoform composition in the thyroarytenoid muscle was examined at the end of @number@ weeks.
Myostatin ( MSTN ) and α-actinin-3 ( ACTN3 ) genes are potentially associated with preservation of muscle mass and oxidative capacity , respectively.
Myotonic dystrophy type @number@ ( DM1 ) is an inherited neuromuscular disease with multisystemic involvement including the central nervous system.
My results showed a positive correlation ; the adjusted OR = @number@ @percent@ CI ( @number@ @number@ ) , p = @number@
Myriad genes and pathways are known to regulate aging in model organisms , fostering a new crop of anti-aging companies.
( Myrtaceae ) or Ma Kiang contains high amounts of phenolic compounds.
N11 inhibited the phosphorylation of p38 MAP kinase and JNK , but not Erk and Akt , in FMLP-induced human neutrophils.
N12D showed a significant reduction of the intracellular MRSA burden without decreasing the macrophage viability.
N12D was found to inhibit MRSA biofilm thickness from @number@ to @number@ μm as observed by confocal microscopy.
N1 latencies , except for the distal urethra , were significantly shorter than those in younger women.
N1 was larger in older adults but did not correlate with accuracy.
N = 99 ( @percent@ ) participants fell @number@ times during the follow-up period ( mean fall rate @number@ per @number@ person years ) .
NAA and Cr ratios did not correlate with myo-inositol , excluding gliosis as the underlying process.
NAA / Cr , Cho / Cr , and Cho / NAA ratios were measured by using turbo spectroscopic imaging.
NA and AA samples were exposed to potential contaminants and treated with the same cleaning conditions.
NAC alone and a solution of NAC and amino acids together , used in aesthetic medicine as intradermal injection treatment , were tested.
N-acetylaspartate was elevated in the BG ( P = @number@ ) .
N-acetyl cysteine , a potent ROS scavenger , did not have comparable effects in the tested cell types.
N-acetyl-cysteine ( NAC ) , an antioxidant , was used to modulate cell growth and ROS.
N-Acetylcysteine ( NAC ) is an acetylated cysteine residue with excellent anti-oxidant activity that boosts glutathione ( GSH ) levels.
Na ( + ) channel inhibition by Nav1.5-E3 antibody directly increased TGF-β ( @number@ ) production in both cultured human cardiac myocytes and fibroblasts.
NAC partially ameliorated the growth disadvantage of DC cells and decreased radiation-induced apoptosis and oxidative stress.
NAC reduced ROS content , however , it did not affect MALAT1 expression.
NAD and NADP are used reversibly in anabolic and catabolic reactions.
NaDC3 is upregulated as organs age , but knowledge regarding the underlying mechanisms by which NaDC3 modulates mammalian aging is limited.
NAD ( + ) -dependent histone deacetylase sirtuin1 ( SIRT1 ) prolongs mammalian cellular lifespan.
Nadir CD4 , but not T-cell activation or senescence , was an independent predictor for low BMD.
NAD is an essential metabolite that exists in NAD ( + ) or NADH form in all living cells.
NAD is necessary for cell survival in oxidative stress and DNA damage.
NAD + levels decline with age in diverse animals from Caenorhabditis elegans to mice.
NADPH can either act as a co-enzyme to produce GSH or a substrate of NADPH oxidase ( NOX ) to generate ROS.
NAD ( P ) H can protect NQO1 from proteolytic digestion suggesting that binding of reduced pyridine nucleotides results in a change in NQO1 structure.
NADPH oxidase is a major source of endogenous reactive oxygen species ( ROS ) .
NADPH oxidase ( NOX ) generates reactive oxygen species ( ROS ) and has been suggested to mediate cell proliferation in some cancers.
NADPH oxidase ( NOX ) may also contribute to ROS production as astrocytes express NOX isoforms.
NADPH oxidases ( Noxs ) are a primary source of ROS in the vascular system and play a central role in cardiovascular health and disease.
NADPH oxidases ( NOXs ) represent one of the major sources of reactive oxygen species in the vascular district.
NAD synthase-NMNAT acts as a chaperone to protect against neurodegeneration , injury-induced axonal degeneration and also correlates with DNA synthesis during cell cycle.
NAD + was also demonstrated by the authors to improve the life span of mice.
( NAFLD ) encompasses conditions associated to fat deposition in the liver , which are generally deteriorated during the aging process.
NAFLD increases the risk for cholesterol gallstone disease by unclear mechanisms.
NAFLD is a major form of chronic liver disease that is highly prevalent in obese and overweight adults and children.
NAFLD was identified after exclusion of other causes of liver fat.
Naïve performance with one arm and the same-arm performance following opposite arm adaptation were compared to determine the extent of transfer in each age group.
Namely , neuroprotectin D1 , a DHA derivative , may support brain cell survival and repair through neurotrophic , anti-apoptotic , and anti-inflammatory signalling.
Namely , the Simon effect was only present after congruent but not after incongruent trials for the positive manipulation group.
Namely , underlying iron deficiency itself , both in those with or without anaemia , can have effects on symptoms and quality of life.
Namely , we quantify this by a percentage that reflects the number of studies showing performance enhancing effects of MPH.
Namibia introduced single-donor apheresis PLT collections in @number@ to increase PLT availability while reducing exposure to multiple donors via pooling.
Naming familiar melodies , but not other music tasks , was strongly related to measures of semantic memory.
NAMPT-mediated lifespan expansion has caused a focus on the catalytic mechanism , regulation and inhibition of NAMPT.
NAMPT provides the mechanism to replenish the NAD pool in human metabolism.
Nanobubbles , without cationic surfactants , showed no cytotoxic effects on neutrophils in terms of inflammatory responses.
Nano delivery of therapeutics can perform both additive and arrestive functions influencing the environment either way , depending on the targeting.
Nanodelivery provides a means to control stability , solubility , and bioavailability , and also provides controlled release of food bioactives.
Nanoencapsulation has been suggested as a promising solution to overcome RSV stability issues.
NANOG increased the expression of smooth muscle α-actin ( ACTA2 ) as well as the contractile force generated by cells in three-dimensional microtissues.
Nanoindentation testing and atomic force microscopy imaging were used to study the mechanical properties and surface morphology of the specimens.
Nanoleakage increased for all groups except MO after storage.
Nanoleakage was not affected by simulated aging.
Nanomedicine aims to provide novel tools for diagnosis , therapy and point-of-care management of patients.
Nanomedicine provides an opportunity to improve the delivery efficiency of orally administered drugs.
Nanoparticles without cationic surfactants revealed a negligible change on immune and inflammatory responses.
Nanosecond laser resolved drusen independent of retinal damage and improved BM structure , suggesting this treatment has the potential to reduce AMD progression.
Nanosomes encapsulating fluorescent dye and conjugated to collagen type II antibody were utilized to detect cartilage damage in vivo.
Nanostructured lipid carriers and poly ( lactic-co-glycolic ) acid nanoparticles were manufactured as lipid and polymeric systems , respectively.
Nanostructured lipid carriers ( NLC ) are well-known systems that show effectiveness to improve skin hydration , being suggested for cosmetic and dermatological use.
Nanotechnology offers emerging therapeutic strategies , which may have advantage overclassical treatments for atherosclerosis.
Nanotoxicology is an emerging regulatory concern and still a challenging field.
Não existem fórmulas predeterminadas para a seleção de problemas prioritários.
NapoE is predominantly expressed in the liver of N. guentheri , consistent with that in mammalian species.
Naproxen / esomeprazole is a fixed-dose combination of the NSAID naproxen and the proton pump inhibitor esomeprazole.
Narrative data were analyzed both for content and inductively.
Narrative data were collected from older persons who had applied for home modification services and from professionals involved in these services in Sweden.
Narrative inquiry and the three-dimensional narrative inquiry space were used to guide the researcher during data collection and analysis.
Narrow phase angle was significantly associated with mortality even among participants with little or no comorbidity.
NART also significantly added to predictions of change in Logical Memory II and Letter-Number Sequencing over a 7-year period.
NART significantly added to predictions of all three measures of memory , after controlling for age , level of education and socioeconomic status.
Nasal and temporal thicknesses were similar on either side of the center.
Nasal bone height and maxillary bone thickness were also not significantly related.
Nasal obstruction in the elderly is a common problem and appropriate diagnosis and treatment are important for improving their quality of life.
Nasal obstruction is one of the most common symptoms in patients affected by rhinosinusitis.
Nasal symptoms were more severe and eczema more common in participants with both asthma and allergic rhinitis than in the other groups.
Nascent regenerative technologies offer unprecedented prospects in achieving repair of degenerated , diseased , or damaged tissues.
Nasopharyngeal cancer ( NPC ) incidence varies widely across geographic regions and ethnic groups.
Nasopharyngeal specimens collected during acute respiratory illnesses were tested for @number@ viruses.
Nasopharyngeal swab specimens were collected from each participant and selectively cultivated.
Nasu-hakola disease ( NHD ) is a rare disease characterized by bone cysts and fractures , frontal lobe syndrome , and progressive presenile dementia.
NAT10 is highly expressed in malignant tumors , and is also a promising target for therapies against laminopathies and premature aging.
National Adult Reading Test and Odor Memory / Discrimination Test scores were positively influenced by HRT.
National and international recommendations could be updated based on the findings of this study.
National blood use patterns in sub-Saharan Africa are poorly described.
National comparative studies are still needed to examine the effectiveness of various surgical options for the treatment of thumb CMC joint arthritis.
National cost increased from $ 1.0 to $ 1.6 billion ( p < @number@ ) .
National costs and lost GDP resulting from missing workers due to back problems were also projected.
National data from the Asia-Pacific region suggest that stroke accounts for over @percent@ of female deaths.
National data were used to estimate the average annual benefits from averting the direct medical costs of a fall.
National Health Service ( NHS ) resource use data were collected from databases of local healthcare providers.
National Health services are now facing a huge shift in the population structure with a predominance of older generations in the total number of citizens.
National Institute for Health and Care Excellence ( NICE ) has listed ten quality standards for supporting people in living well with dementia.
Nationally representative prevalence estimates for children under @number@ years according to sex and race / ethnicity have not been reported.
National prevalence estimates and weighted percentages of those reporting driving self-restrictions were calculated.
National public health policies should be strengthened to reduce hip fracture incidence and mortality.
Nationwide initiatives to develop and implement policies and strategies to protect cognitive health throughout the lifespan should be considered a public health priority.
Nationwide population-based cancer surveillance has been built up.
Nationwide , there was a mean of @number@ AUGS member for every @number@ practicing general
Nativity status was the most important moderator for age-related PA decline.
Natural age related changes in the eyes or ocular diseases can result in reduced visual function and performance.
Natural audio-lead asynchronies are arguably more predictable than natural visual-lead asynchronies , and this predictability may render audio-lead thresholds more prone to experience-related fine-tuning.
Natural biological factors such as aging and an individual's sex also affect underlying tissue biomechanics in different brain regions.
Natural ingredients are frequently used in an effort to address cosmetic concerns such as fine lines , wrinkles , uneven tone , and texture.
Naturalistic driving data may ultimately be critical for understanding the relationship between vision and driving safety.
Natural killer ( NK ) cells are bone marrow-derived lymphocytes crucial for host defense against several infections and cancer.
Natural lung aging is marked by molecular changes that occur during development , maturation , and late-life decline.
Naturally acquired immunity to pneumococcal capsular polysaccharides develops during childhood and is robust in young adults but deteriorates with advanced age.
Naturally attrited , extracted human teeth with occlusal-transparent dentin were investigated in comparison to sound and carious teeth.
Naturally , its functioning and structure also change dynamically in a depth-dependent manner.
Naturally occurring propagating regenerative hair waves peculiar to mice were preserved.
Naturally Occurring Retirement Community ( NORC ) Supportive Service Programs constitute one of the longest-standing models for age-friendly community initiatives.
Natural menopause is a normal physiological process that can only be directly studied through observational research.
Natural products or nutraceuticals have been shown to elicit anti-aging , anti-cancer and other health-enhancing effects.
Natural products with anti-aging property have drawn great attention recently but examples of such compounds are exceedingly scarce.
Natural selection is traditionally viewed as a leading factor of evolution , whereas variation is assumed to be random and non-directional.
Natural selection often acts simultaneously at more than one level of biological organization and on specific traits , which we define as multilevel selection.
Natural telomere shortening is an inevitable consequence of aging , which is also a risk factor for development of lung disease.
Natural water in Northern Xinjiang was mainly fresh soft water , and it was mainly fresh hard water and brackish hard water in Southern Xinjiang.
Nature.
Nature 399 : 255-258 ] .
Nature has developed numerous mechanisms to counteract these problems , such as proofreading enzymes , ubiquitous antioxidants and apoptotic death of unfit cells.
Nausea and urinary tract infections occurred more frequently in the senicapoc group than placebo.
Navigating without vision to a remembered target has previously been studied.
Navigational and reaching spaces are known to involve different cognitive strategies and brain networks , whose development in humans is still debated.
Navigation services and physician recommendation were suggested facilitators to screening.
Navigation without vision is a skill that is often employed in our daily lives , such as walking in the dark at night.
NA was not associated with mortality.
NBCC's garden program serves as a model in early childhood education and as a community-based intervention to improve family health and prevent child obesity.
N ( ϵ ) - ( carboxymethyl ) lysine ( CML ) AGE is one of the major biologically and chemically well-characterized AGE markers.
NC are owned and operated by distributors of Herbalife products.
NCDs cluster and co-morbidities increase in parallel to age.
NCI was defined using global and seven domain deficit scores.
NCOA1 and NT5C3B were associated with the midlife aβ42 : aβ40 ratio and the fold-change in aβ42 , respectively , via SKAT in African Americans.
NCS demonstrated a bimodal age distribution.
NCT01222702 and in Europe with the European Medicines Agency under registration no.
( NCT01649960 ) .
NCT01777763. ) .
( NCT01871012 ) .
NE activity was examined by in situ zymography.
Near and distance fusional vergence reserves were measured using prism bar , and near associated phoria was assessed using the Mallett unit.
NearDVA declined with HTcoupling ( p = 0.021 ) .
NearDVA is more sensitive to normal aging process.
Near falls ( NFs ) are more frequent than falls , and may occur before falls , potentially predicting fall risk.
Near fiber ( NF ) MU potential analysis was used to assess neuromuscular transmission stability.
Nearly all agencies stored ADs in a file at the agency , but only half stored them at the patient's residence.
Nearly all of them had considered , but few had started , a process of sorting out objects.
Nearly all studies of dual task performance in PD employ walking or balance-based motor tasks , which are commonly impaired in PD.
Nearly every aspect of skin biology is affected by aging.
Nearly half of all people with musculoskeletal pain were housewives , and the average age between groups was over @number@
Nearly half of people aged over @number@ years are inactive.
Nearly half of people living with HIV experience cognitive deficits that may impact instrumental activities of daily living.
Nearly half of the patients ( @number@ of @number@ ) had MCI according to the modified Petersen criteria.
Nearly half of the respondents had a hypertensive blood pressure when measured during the interview , but had not been previously diagnosed.
Nearly @number@ in @number@ hematomas < 30 mL expands , leading to END or death.
Nearly @number@ participants were presented with about @number@ word stimuli ( selected from a list of @number@ words ) in an adapted lexical decision task.
Nearly one quarter of the sample had improved their nutritional status at the time of discharge.
Nearly one-quarter of these units ( @percent@ ) were issued for gastrointestinal ( K20-K93 ) diagnoses.
Nearly @percent@ of all ED visits had ambulatory care sensitive condition diagnoses.
Nearly @percent@ of Americans will have an operation after the age of @number@ years.
Nearly @percent@ of seniors living in the community expect to obtain nursing care , while only @percent@ do not expect any social or nursing help.
Nearly @percent@ of the pregnant women conceived spontaneously.
Nearly @percent@ of the sample had hospice stays less than @number@ weeks and up to @percent@ had stays greater than @number@ months.
Nearly @percent@ of the sample maintained a low SEP throughout life.
Nearly @percent@ of these deaths occurred within 24h of admission indicating a high level of less appropriate admissions.
Nearly @percent@ of the variance in 3DGI was due to genes , and 3DGI had a strong phenotypic and genetic association with SA.
Nearly @percent@ percent of those < @number@ years scored below the standard for lower body strength.
Nearly three-fourths ( @percent@ ) of participants were found to have hypertension.
Nearly two-thirds of homebound and over half of semi-homebound older adults with clinically significant depressive symptoms also had significant anxiety symptoms.
Nearly two-thirds ( @percent@ ) had already been treated for osteoporosis , mainly with bisphosphonates.
Near normal morphology of mitochondria was also detected in ECs and perivascular astrocytes from transplanted stroke rats.
Near @percent@ of the rehospitalized patients were for hip fractures occurring in a median of @number@ days after hospitalization for proximal humerus fracture.
Near the top of the list , the neuron-specific gene , RIT2 , contains one of the longest GA-STRs at 11-repeats.
Near transfer was seen to non-trained updating and inhibition tasks for the young and older trained participants.
Near VI was associated with lower DSST scores but not higher odds of DSST impairment.
Nebivolol is a third-generation β1-blocker with vasodilating properties mediated by β3 adrenergic receptors ( β3AR ) .
Nebivolol-mediated lipolysis was blocked by SR59230A , a specific β3AR antagonist , suggesting that nebivolol acts through β3AR in human adipocytes.
Nebulizers should be considered for patients unable to use handheld inhalers properly.
Necessity of relocation associated with medical deterioration was consistently given the greatest importance.
Neck CSA-normalized peak EMG amplitudes negatively correlated with age for the cervical paraspinous and sternocleidomastoid.
Neck pain is a major component of current clinical clearance guidelines , but some older adults with c-spine fractures report no neck pain after injury.
Need for and use of services was frequently reported.
Need for further development Despite the aforementioned merits , there are important needs for improvement of van der Klink et al's definition of SE.
Need for operative intervention , mechanism of injury , and comorbidities were similar between the two groups.
Needle injection relied on a perpendicular transcutaneous approach , whereas cannulas were moved in the supra-periosteal plane until reaching the same location as the needle.
Needs and preferences for a nutrition education and foods skills program were explored in adults with developmental disabilities , agency managers , and support workers.
Need-standardised DMP enrolment was predicted in multi-level logistic regression models.
Negative affect and stressors were unrelated to subsequent sleep.
Negative age stereotypes are pervasive and threaten older adults ' self-esteem.
Negative age stereotypes that older individuals assimilate from their culture predict detrimental outcomes , including worse physical function.
Negative and positive processing exhibited low , but significant , stability.
Negative and positive symptoms also worsened ( Cohen's d values , @number@.45-0.73 ) .
Negative aspects of close relationships , but not positive aspects , were associated with accelerated cognitive aging.
Negative aspects , such as performance-related stress and injury , also have an effect.
Negative attitudes toward patients with a history of illicit drug use can adversely affect the therapeutic nurse-patient relationship , resulting in suboptimal patient care.
Negative attitudes were most frequently associated with health risks and social problems arising from using technology ( e.g. , social isolation and addiction ) .
Negative binomial and logistic regression models assessed disparities in access to routine care , ambulatory service intensity , and hospital utilization.
Negative binomial regression analysis was used to determine the correlates of depression symptom severity.
Negative binomial regression results find state minority population percentage is a significant predictor of the number of diversity initiatives at CMPs.
Negative binomial regression was performed for individual and within-pair effects.
Negative binomial regression was used to identify significant census tract-based neighborhood environmental variables associated with the count of fall injuries in each census tract.
Negative but not positive exchanges with other family and with friends were associated with depression.
Negative correlations were found between age and MEB scores for all groups , particularly the NC and RBD groups.
Negative correlations were found for negative emotions.
Negative correlation was observed between iPTH and muscle function ( r = @number@ p < 0.02 ) .
Negative emotionality and depressive symptoms were not related to the cortisol awakening response.
Negative emotionality has been shown to be associated with telomere shortening.
Negative emotional reactivity did not predict mortality.
Negative emotional response was assessed by self-report at baseline.
Negative framings were predominantly generalisations to these workers as a group.
Negative future events were less likely to be a continuation of chapters and were more temporally distant than positive future events.
Negative hallucinations create blank spaces , due to both an impossible representation and an incapability of investment in reality.
Negative immunostaining for eEF1A2 was shown to be an independent prognostic factor and significantly correlated with lymph node metastasis.
Negative local correspondence suggests detrimental effects of Aβ on iFC in network centers , starting at preclinical stages , and peaking when first symptoms appear.
Negatively skewed data arise occasionally in statistical practice ; perhaps the most familiar example is the distribution of human longevity.
Negative outcomes for health are possible when an age-related imbalance appears between physical workload and physical work capacity.
Negative perceptions most influential in discouraging relocation reflected a fear of losing independence and privacy.
Negative predictive value was @percent@.
Negative pressure wound therapy ( NPWT ) has also been used successfully for the treatment of wounds.
Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells.
Negative relationship quality predicted increased blood pressure when both members of the couple reported negative quality relations.
Negative rGMV correlates of systemizing were found in an area close to the left posterior insula and putamen.
Negative significant correlation was observed between serum fructose and serum total antioxidant status in diabetic and non-diabetic patients with myocardial infarction.
Negative stereotypes about aging can impair older adults ' memory via stereotype threat ; however , the mechanisms underlying this phenomenon are unclear.
Negative stereotypes tend to dominate , but a persistent positive perception of aging in the popular psyche is that age brings wisdom.
Negative street characteristics , for example , lack of sidewalks and streetlights , were negatively associated with physical activity in adults.
Negative symptoms are often observed in chronic-course psychosis , but occur infrequently in late-onset-schizophrenia.
Neglect , abuse and violence against older women has not been a prominent focus of elder abuse research.
Neglect and physical abuse were the most common types diagnosed , accounting for @percent@ and @percent@ of cases , respectively.
Neglect was recognized by @number@ % of nurses and @number@ % of students , respectively.
Neighborhood cohesion was measured using six questions.
Neighborhood compactness was assessed objectively using geographic information systems via a subsequent grant ( @date@ ) .
Neighborhood context may influence health and health disparities.
Neighborhood design and maintenance must be evaluated to promote physical activity , mobility , and safety.
Neighborhood disorder , moreover , was associated with incident functional limitations only among the most educated seniors.
Neighborhood environments were audited.
Neighborhood environments were measured by geographic information systems and validated questionnaires.
Neighborhood level socioeconomic characteristics should also be an important consideration when identifying vulnerable populations that may benefit the most from fall prevention programs.
Neighborhood median family income was obtained through public census databases.
Neighborhood safety , social cohesion , and walkability were multi-component scale variables that were standardized due to varying response metrics.
Neighborhood self-perception revealed that @percent@ of the elderly were satisfied with their neighborhood , although only @percent@ trusted people around them.
Neighborhood socioeconomic differences may influence the consumption of carotenoid-rich foods , as indicated by serum carotenoid concentrations.
Neighborhood socioeconomic status ( SES ) indicators were assessed at census block group level.
Neighborhood socioeconomic status was assessed from census data.
Neighborhood socioeconomic Z-scores were derived from characteristics of the census block of the participants.
Neighborhoods with higher residential density and having a higher vacancy rate were associated with increased count of fall injuries.
Neighborhood walkability and access to green space improved over the 18-year study period.
Neighborhood walking was significantly associated with self-efficacy for individual barriers in both groups.
Neighbors were preferred when kin were not available.
Neighbourhood disadvantage was measured at the census tract level using data from the @number@ Canada Census.
NEIL1 is also regulated by RAD9 through a similar DNA sequence , though not yet directly verified as a bonafide p53 response element.
NEIL2 is thus likely to play an important role in long term genomic maintenance , particularly in long-lived mammals such as humans.
Neither 4-PPBP , nor either of the haloperidol metabolites affected the level of BDNF mRNA as assessed by qPCR.
Neither achievement of ≥10 @number@ steps / day nor ≥30 min / day of MPA resulted in improved FMD%.
Neither age added incrementally to static score in the prediction of sexual recidivism.
Neither age , cognitive status , nor gender moderated any of the relationships.
Neither age group benefitted from additional learning trials beyond Trial @number@ for storage and Trial @number@ for retention and retrieval.
Neither age nor gender predicted training or booster effects , indicating the generality of training effects across age ( 65-90 years ) .
Neither age nor renal function was a predominant factor of pharmacokinetic variability.
Neither age , nor task-type , nor IQ reduced the observed heterogeneity , suggesting that these were not crucial moderators within the current meta-analysis.
Neither aging nor changes in antipsychotic treatment accounted for the declines.
Neither aging nor frailty changed this association.
Neither aging nor smoking correlated significantly with the formation of MN.
Neither Al treatment nor genotype had any noticeable effect on corticosterone levels and Al concentrations in frontal cortex and cerebellum of the mice.
Neither appears currently promising.
Neither baseline fall history nor performance of activities of daily living accounted for these differences.
Neither baseline levels nor slopes of IL-6 were related to cognitive impairment or hippocampal volume.
Neither behavioral nor biological factors explained why the gender difference in LTL was smaller at older ages.
Neither Black nor Hispanic youth appear to benefit from living in higher-income neighborhoods.
Neither BMI nor MNA scores had any significant correlation with adiponectin , ghrelin , IGF-1 , or IGFBP-3.
Neither BMI nor obesity status were associated with 30-day mortality after ICH.
Neither body mass index nor other physiologic parameters found on electrocardiography , echocardiography , or cardiac catherization were different between groups.
Neither BT nor YP affected the rapid vasodilator response in the older sedentary group ( P > @number@ ) .
Neither candidate gene studies nor an initial genome-wide association study ( GWAS ) have yielded significant and replicated results.
Neither criterion is well defined.
Neither crowding nor surround suppression was predicted by attentional efficiency measured in the visual search task.
Neither dementia nor antidepressant medication modified the relation of pathology to depression.
Neither desirable nor excessive BMI reductions ( vs no change / increased BMI ) were associated with poststroke mortality.
Neither did we observe an association of LTL-associated genetic variants with mortality in a prospective meta-analysis of multiple cohorts ( n = 8165 ) .
Neither dietary nor supplemental intake of vitamin A or vitamin C nor supplemental intake of vitamin E was significantly associated with mortality after multivariate adjustment.
Neither does AMH predict the chances of spontaneous pregnancy nor the success rates of ovarian stimulation with / without intra-uterine insemination.
Neither do we know whether it is the number per se or the type of medications that actually matters.
Neither eGFR nor eCCr were associated with lADRs.
Neither FA nor PA was related to cognitive status.
Neither feelings of usefulness nor volunteering were directly associated with depressive symptoms.
Neither FH nor apoE-deficient humans showed significant alterations in apoA-I-containing HDL particles as compared to non-carriers.
Neither functional status nor severity of dementia was associated with QoL ; but depressive symptoms and self-reported feeling ill had a negative association on QoL.
Neither gender , ethnicity , level of training , nor hospital location demonstrated a significant correlation to either knowledge or attitude scores.
Neither gender nor refractive error showed any significant difference in various ONH parameters.
Neither genomic African nor Native American ancestry had an effect modifier on the associations ( P for interaction > 0.05 for all ) .
Neither group were highly efficient at managing care-related stress , but both identified benefits from taking time off or maintaining interests outside of caregiving.
Neither HF types nor specific dementia disorders were associated with survival.
Neither hormone was correlated with shorter LTL in MDD ( p's > 0.28 ) .
Neither household income nor employment grade was related to telomere length.
Neither hyaluronic acid formulation had a longer duration of clinical benefit than the saline control.
Neither hyper- nor hypopigmentation of the skin was found.
Neither IGF-1 level nor IGF-1 score were different in the two groups.
Neither intervention demonstrated any further effects on inflammation.
Neither left atrial size nor left ventricular mass had significant impact.
Neither lens status nor diabetic status affected CST , MT , or MV.
Neither lipid rich necrotic core nor calcium in the SFA were associated with mobility loss.
Neither locus was associated with FEV1 decline in two additional cohort studies.
Neither low- nor high-density lipoprotein cholesterol GRS was significantly associated with MAC.
Neither LV mass nor exercise capacity was affected by alagebrium.
Neither lymph node status nor lymphangioinvasion were significantly associated with a poor survival.
Neither macroscopic infarcts nor microscopic infarcts were associated with cortical or hippocampal atrophy ( p's > @number@ ) .
Neither mean keratometry nor spherical equivalent was correlated with corneal densitometry in any zone of the cornea ( p > @number@ ) .
Neither measure was sensitive to the effects of sex after adjusting for the effects of age and education.
Neither metformin nor platelets altered proliferation ; however , metformin inhibited the increase in phosphorylation of focal adhesion kinase induced by platelets.
Neither model is accurate enough to be relied on solely for determination of driving ability.
Neither morphology nor age influenced the winding angle around the mediastinum.
Neither mutation altered Psen1 mRNA expression , but both abolished γ-secretase activity.
Neither of cases developed diabetes in the 24-month follow-up period.
Neither of the glutathione S-transferase variants was independently associated with cognitive function , nor with lead biomarker measures.
Neither of the other authors has a financial or proprietary interest in any material or method mentioned.
Neither operative duration nor off-hours surgery was associated with increased mortality.
Neither p53 nor its target gene p73 was required for G2 / M arrest.
Neither paradoxical sleep deprivation nor sleep restriction increased genetic damage , measured by tail movement and tail intensity values.
Neither parameter associated with soft tissue thickness.
Neither participants ' motivation nor their anticipatory emotions correlated with the individual coefficients of variation of the trunk muscle moment measurements.
Neither participants nor health-care providers will be blinded , however all research assistants and researchers will be blinded.
Neither pathology nor age affected temporal ( saccade latencies and durations ) and spatial ( saccade amplitude ) parameters of eye movements.
Neither PLMI nor PMLA was associated with subjective sleepiness measured by the Epworth Sleepiness Scale.
Neither prevalence ( p = 0.48 ) nor incidence ( p = 0.18 ) sex ratios changed significantly between @number@ and @number@
Neither quality of life nor appetite measures were improved.
Neither self-identified race / ethnicity nor genetic ancestry were associated with annualized %ΔBMD.
Neither sex nor smoking status influenced NET availability.
Neither social support nor deprivation appeared to have any effect on SRH regardless of reporting heterogeneity.
Neither testicular enlargement nor increased sperm count was observed , thus a secretion of FSH with reduced biological activity was supposed.
Neither the amplitude nor latency of ocular VEMP was associated with gait speed in men or women.
Neither the attention nor the no-treatment control groups had significant gains immediately postintervention or at follow-up assessments.
Neither the hypothesis suggesting a significant contribution of parentally transmitted trisomy @number@ to DS population rate has been confirmed.
Neither their cause nor connection to the metabolic syndrome ( MS ) is clear.
Neither the MDS nor the dietary patterns identified by FA were associated with risk of cognitive impairment in men.
Neither the molecular mechanisms underlying heart failure nor effective prevention strategies are fully understood.
Neither the pre-cementation treatment nor the artificial aging had a statistical significant effect on the fracture strength.
Neither the reported level of physical activity nor additional sport nor self-reported calcium intake influenced the reference equations.
Neither the VF-MD nor pattern standard deviation was found to be associated with CT.
Neither traditional cardiovascular risk factors nor markers of inflammation / adhesion molecules explained the difference in leukocyte telomere length between ultra-marathon runners and controls.
Neither transportation PA nor moderate LTPA was significantly associated with LTL.
Neither treatment showed significant vaso-protective effects in retinopathy.
Neither trend is primarily due to observable demographic or socioeconomic factors.
Neither tyrosine neurons in the locus ceruleus nor tryptophan neurons in the dorsal raphe nucleus were related to depressive symptoms.
Neither unfitness on CGA nor MPI score were significantly related to thymic output or telomere length in either group.
Neither variable was dependent on age.
Neither vitamin E nor vitamin C supplementation had effects on other site-specific cancers overall.
Neither was any significant difference displayed between students , based on gender nor for previous work experience.
Neither weight nor WC gains were associated with dental status.
Neither young nor older adults were advantaged when judging a speaker from the same age group.
Neoadjuvant and adjuvant chemotherapy regimens have been evaluated , as well as the quality of cystectomy and pelvic lymph node dissection.
Neocortical BF-227 uptake negatively correlated with glucose metabolism.
Neocortical gamma activity is crucial for sensory perception and cognition.
Neocortical neurofibrillary tangles were the strongest predictors of most domains , while medial temporal tangles showed a weaker relationship with episodic memory.
Neocortical ODI outperformed cortical thickness and white matter fractional anisotropy for the prediction of chronological age in the same individuals.
Neonatal and adult T cells differ in their effector functions.
Neoplasms and cardiovascular diseases accounted for @percent@ of deaths.
Neoplastic tissues usually retain the color of their nonneoplastic counterpart.
Neopterin correlated with NFL levels in untreated groups while the albumin ratio correlated with NFL in both untreated and treated groups.
Neopterin levels independently related to higher numbers of enlarged Virchow Robin spaces ( p < @number@ ) .
Neopterin , sICAM-1 and sVCAM-1 levels were higher in patients with extensive CSVD manifestations than in those without ( p < @number@ ) .
Neovascular disease ( NV ) and geographic atrophy ( GA ) were evaluated separately.
Nephrologists have a therapeutic relationship with their patients that may span decades.
Nephrologists need to collaborate closely with other sectors and governments , to reach these aims.
Nephrologists should notice the importance of △HRV especially in high-risk patients.
Nephrologists worldwide are gradually coping with elderly patients.
Neprilysin ( NEP ) , a rate-limiting catabolic peptidase is involved in Aβ metabolism in vivo.
N-epsilon-Hexanoyl-lysine ( HEL ) is a novel lipid peroxidation biomarker which is derived from the oxidation of omega-6 unsaturated fatty acid.
NER is initiated by arrested RNA polymerase or damage recognition by XPC-RAD23B with or without DDB1 / DDB2.
Nerve agents are chiral organophosphate compounds ( OPs ) that exert their acute toxicity by phosphorylating the catalytic serine of acetylcholinesterase ( AChE ) .
Nerve cell microcircuits are modified by excitatory and inhibitory synaptic activity and neurotrophic factors.
Nerve samples were stained and quantified.
Nesprins and emerin are structural nuclear envelope proteins that tether nuclei to the cytoskeleton.
Nesprins are a family of proteins that are primarily known for their localization along the nuclear envelope.
Neste cenário , o presente artigo visa aprofundar o entendimento sobre inovação nos serviços de saúde.
Nested PCR successfully detected @number@ Plasmodium falciparum or Plasmodium vivax infections , which were missed in microscopic examination.
Nestin phosphorylation at threonines @number@ ( Thr315 ) and @number@ ( Thr1299 ) was observed during mitosis in human pancreatic cancer cells.
Nestin phosphorylation was positively correlated with a cell proliferation marker , MIB-1 expression in human pancreatic cancer samples.
NetPS was stimulated comparably , with a protein conversion rate greater than @percent@.
Net reclassification improvement was highest after updating 10-year CVD risk with CTCS : @number@ ( 95%CI @number@ @date@ ) .
NETs could be quickly formed , within minutes , after CTAB liposomal treatment.
Network-based statistics revealed a significant increase of structural connectivity in a frontolimbic network.
Network distance travelled from home to injury site was not associated with the occurrence of severe pedestrian injuries among older people.
Network growth was more common than network shrinkage.
Network-level analysis revealed age-related alterations in network recruitment consisting of diminished activations of DAN and diminished deactivations of DMN in older relative to younger adults.
Network losses were associated with physical but not psychological well-being.
Network motif ( NM ) analysis of these genes revealed @number@ three-node NMs , suggesting complex interactions between inflammatory mediators and transcription factors.
Network properties were significantly correlated to age , whereas no significant correlation to WAIS-R was observed.
Network representation of brain connectivity has provided a novel means of investigating brain changes arising from pathology , development or aging.
Network science approaches have facilitated these analyses and allowed examining the brain as an integrated system.
Network size is a count of the number of friends.
Networks of inter-related transcription factors regulated by E2F1 are loading-responsive in both age groups.
Networks of miRNAs targeting mRNAs , both DE by age and gender , were identified.
Networks of oncogenes and tumor suppressor genes that control cancer cell proliferation also regulate stem cell renewal and possibly stem cell aging.
Networks of proto-oncogenes and tumor suppressors that control cancer cell proliferation also regulate stem cell self-renewal and possibly stem cell aging.
Network volumes were measured using 3D reconstructions of confocal stacks.
Neural activation of agonist and antagonist muscles may also be important contributing factors.
Neural activity correlating with @number@.14- to @number@.21-Hz EIG ( suggested to reflect intestinal activity ) was observed in the right anterior and middle insula.
Neural aging as a progressive loss of function involves central and peripheral post-mitotic neurons and neural stem cells ( NSCs ) .
Neural compensation refers to the increased ability to recruit new , additional functional resources.
Neural correlates of visual search , and their potential dissociation , were examined here using integrity of white matter connecting the frontoparietal networks.
Neural data showed that as task difficulty increased , the amplitude of the parietal P3b component during the probe phase decreased and its latency increased.
Neural innervation of the colon and the effects of aging on intrinsic and extrinsic nerves innervating the colonic smooth muscle is discussed.
Neurally , e4 + showed less task-related recruitment of extrastriate and parietal areas.
Neurally mediated syncope ( NMS ) patients suffer from sudden loss of consciousness , which is associated with a high rate of falls and hospitalization.
Neurally medicated syncope ( NMS ) patients suffer from sudden loss of consciousness , which is associated with a high rate of falls and hospitalization.
Neurally , we observed an adolescent peak in risk-related activation in the anterior insula and dorsal medial PFC.
Neural measures reveal individual differences in controlling access to working memory.
Neural network outperformed it with classification accuracy over @percent@ using @number@ tags with 0-20 mm noise.
Neural networks supporting memory function decline with increasing age.
Neural oscillations in the theta band have repeatedly been implicated in successful memory encoding and retrieval.
Neural plasticity is a probable explanation for positive training effects.
Neural precursor cell expressed , developmentally down-regulated ( NEDD9 ) gene was a new candidate risk gene for Alzheimer disease ( AD ) .
Neural precursor cells proliferate and migrate along cerebral microvessels to the ischemic lesion.
Neural reserve refers to increased efficiency and / or capacity of existing functional neural resources.
Neural responses to distractors in auditory cortex were selectively reduced in both species , mimicking the behavioral effects.
Neural stem cell properties , such as self-renewal and multipotency , are modulated by both cell-intrinsic and cell-extrinsic factors.
Neural synchrony is largely dependent on phase locking within the central auditory pathway , beginning at the auditory nerve.
Neuraminidase , which cleaves glycosidic linkages of apical adherens junction proteins , was administered intracerebroventricularly to denude areas of ependymal cells.
Neuregulins provide key axonal signals that regulate several processes , including glial cells proliferation , survival and myelination.
Neurexins ( NRXNs ) are presynaptic terminal proteins and candidate neurodevelopmental disorder susceptibility genes ; mutations presumably upset synaptic stabilization and function.
Neuritic AD-pathology was low ( mean Braak stages @number@.2-1.6 ) .
Neuritic plaque ( NP ) formation can be dated in vivo.
Neuritic plaques and neurofibrillary tangles , the neuropathological hallmarks of AD , are not limited to individuals with dementia.
Neuritic plaques had relatively strong effects on multiple domains.
Neuroanatomical age was determined by a machine learning system trained to individually estimate age from the structural magnetic resonance imagings of @number@ healthy controls.
Neuroanatomical changes underlying this deficit in the olfactory system are largely unknown.
Neuroaxonal degeneration in the central nervous system contributes substantially to the long term disability in multiple sclerosis ( MS ) patients.
Neurobehavioral Rating Scale inaccurate insight scores were no different in those with and without delusions.
Neurobehavioral scores were used as the major outcome factors for clinical correlations.
Neurobiol.
Neurobiological mechanisms underlying the development of major depressive disorder ( MDD ) may differ depending on age-of-onset.
Neurocognitive abilities were strongly age-related and indirectly correlated with alexithymia.
Neurocognitive aging studies have focused on age-related changes in neural activity or neural structure but few studies have focused on relationships between the two.
Neurocognitive assessment was conducted at baseline , with evaluations at 15-month intervals.
Neurocognitive competence was assessed using a neuropsychological battery measuring attention , language , memory , visuospatial abilities , and executive functions.
Neurocognitive disorders are a feared complication of HIV infection , especially in the post-antiretroviral era as patients are living longer.
Neurocognitive evaluation revealed decreased memory performance in the soccer players compared to controls.
Neurocognitive function was assessed at baseline and week @number@ using a neuropsychological battery.
Neurocognitive impairment ( NCI ) is an increasingly important comorbidity in an ageing HIV + population.
Neurocognitive impairments are strongly associated with functional outcomes ; thus , the treatment of cognitive impairments is of central importance.
Neurocognitive performance correlated with both performance-based and observer-rated social functioning , whereas depressive and manic symptoms correlated only with observer-rated social impairments.
Neurocognitive performance improved with years of ART.
Neurocognitive tests , driving simulation , and road tests provide complementary sources of evidence to evaluate driver safety.
Neurocysticercosis ( NCC ) has been associated with hippocampal atrophy , but the prevalence and pathogenic mechanisms implicated in this relationship are unknown.
Neurodegeneration in bipolar disorder ( BPD ) is poorly understood.
Neurodegeneration is a leading cause of death in the developed world and a natural , albeit unfortunate , consequence of longer-lived populations.
Neurodegeneration is then assessed by measuring the size and / or number of vacuoles that have developed in the fly brain.
Neurodegeneration is the umbrella term for the progressive death of nerve cells and loss of brain tissue.
Neurodegeneration of occipital lobe was indexed by weighted averages of gray matter density , estimated from structural MRIs.
Neurodegeneration refers to the phenomenon of the structural and functional loss of neurons and the rate of which is accelerated by aging.
Neurodegeneration was most prominent in the dentate gyrus and was significantly increased in the cerebellum leading to aggravated motor deficits.
Neurodegenerative and low-level chronic inflammatory processes predispose to exaggerated response to incident stimuli that may precipitate both acute brain dysfunction and persisting cerebral damage.
Neurodegenerative changes are closely linked to inflammatory processes and oxidative stress.
Neurodegenerative diseases affect a considerable percentage of the elderly population.
Neurodegenerative diseases affect not only the life quality of aging populations , but also their life spans.
Neurodegenerative diseases , Alzheimer's disease ( AD ) and Parkinson's disease ( PD ) , constitute a major worldwide health problem.
Neurodegenerative diseases are a very diverse group of disorders but they share some common mechanisms such as abnormally misfolded proteins with prion-like propagation and aggregation.
Neurodegenerative diseases are characterised by neuronal loss and cerebral deposition of proteins with altered physicochemical properties.
Neurodegenerative diseases are disabling conditions continuously increasing due to aging of population.
Neurodegenerative diseases pose an extraordinary threat to the world's aging population , yet no disease-modifying therapies are available.
Neurodegenerative diseases pose a significant problem for the healthcare system , doctors , and patients.
Neurodegenerative diseases share diverse pathological features and among these oxidative stress ( OS ) plays a leading role.
Neurodegenerative disorders are some of the most feared illnesses in modern society , with no effective treatments to slow or halt this neurodegeneration.
Neurodegenerative disorders associated with abundant tau inclusions are collectively described as tauopathies.
Neurodegenerative processes associated with aging may be facilitated by HIV-1 infection , resulting in premature brain aging.
Neurodegenerative process in amyotrophic lateral sclerosis ( ALS ) has been proven to involve several cortical and subcortical brain regions within and beyond motor areas.
Neuroferritinopathy is a rare genetic disease with a dominant autosomal transmission caused by mutations of the ferritin light chain gene ( FTL ) .
Neurofibrillary degeneration induced by misfolded protein tau is considered to be one of the key pathological hallmarks of Alzheimer's disease ( AD ) .
Neurofibrillary tangles ( NFTs ) , composed of hyperphosphorylated tau , are a key pathologic feature of Alzheimer's disease ( AD ) .
Neurofibrillary tangles ( NFTs ) in Alzheimer's disease contain both three repeat ( 3R ) - and four repeat ( 4R ) -tau.
Neurofibrillary-tangle tau pathology tends to be closer to the gray matter-white matter boundary , whereas Aβ is dispersed throughout the width of the cortical ribbon.
Neurofunctionally , this task has been shown to rely on brain regions involved in numerical processing.
Neurogenesis declines with aging.
Neuroglobin ( Ngb ) is a recently discovered globin with preferential localization to neurons.
Neuroimaging analyses have revealed distinct distributions of disease in FTLD patients with genetic mutations.
Neuroimaging analysis revealed the significant preservation of bilateral prefrontal volume in the exercise group with small-volume corrections , although this effect faded after intervention.
Neuroimaging biomarkers differ between patients with early-onset Alzheimer's disease ( EOAD ) and late-onset Alzheimer's disease ( LOAD ) .
Neuroimaging biomarkers play a prominent role for disease diagnosis or tracking neurodegenerative processes.
Neuroimaging can help in describing cerebral reserves , as well as in detecting AD brain pathology before the onset of clinical dementia.
Neuroimaging demonstrated treatment-related slowing of cortical and striatal atrophy at @number@ and @number@ months.
Neuroimaging evidence suggests that less efficient retrieval processing ( temporally delayed and attenuated ) may contribute to these impairments.
Neuroimaging may offer a good tool during diagnosis.
Neuroimaging results have recast our framework around cognitive aging from one of decline to one emphasizing plasticity.
Neuroimaging studies demonstrate considerable changes in white matter volume and microstructure during adolescence.
Neuroimaging studies utilizing connectivity methods like resting-state fMRI and diffusion MRI continue to uncover tinnitus-related anomalies throughout auditory , limbic , and other brain systems.
Neuroimaging techniques offer invaluable tools to understand the biological substrate of the disease.
Neuroimaging tests showed the same brain involvement.
Neuroinflammation- and neurodegeneration-induced nerve injury may represent important components of neuropsychiatric lupus ( NPSLE ) .
Neuroinflammation caused by local deposits of Aβ BACKGROUND : Limited data are available regarding fit and healthy patients with pneumonia at different ages.
Neuroinflammation has been implicated in the pathogenesis or the progression of a variety of acute and chronic neurological and neurodegenerative disorders , including Alzheimer's disease.
Neuroinflammation is a common feature of acute stroke and is considered to be a major obstacle to endogenous neurogenesis and exogenously administered stem cells.
Neuroinflammation is a key event in neurodegeneration and aging , and there is mounting evidence of LRRK2 involvement in inflammatory pathways.
Neuroinflammation is a major hallmark of amyotrophic lateral sclerosis ( ALS ) , which is currently untreatable.
Neuroinflammation is considered a chronic activation of the immune response in the central nervous system ( CNS ) in response to different injuries.
Neuroinflammation mediated through cytokines plays a pivotal role in the pathogenesis of dementia.
Neuroinflammation plays a key role in many neurodegenerative disorders , including postoperative cognitive decline ( POCD ) .
Neuroinflammation plays an influential role in Alzheimer's disease ( AD ) , although the mechanisms underlying this phenomenon remain largely unknown.
Neurological accidents involving the internal capsule indicate differential functional correlates with its sectors.
Neurological and global physiotherapeutic assessments showed a statistically significant correlation.
Neurological complications did not occur in low-energy injuries.
Neurological deficits were assessed in weeks @number@ through @number@ after HI.
Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations , which greatly contributes to increasing healthcare costs.
Neurological disorder and cancer were less common , but had the most debilitating effects on patients.
Neurological disorders are becoming increasingly common in developed countries as a result of the aging population.
Neurological disorders , such as neuropathic pain , chronic pain syndrome , peripheral neuropathy and several central nervous system disorders , are related to DED.
Neurological effects of MB have been reported in clinical observations and experimental studies.
Neurological examination at age @number@ revealed severe weakness and atrophy in the tibialis anterior muscles and distal predominant moderate weakness in the extremities.
Neurological examination revealed disturbed consciousness , muscle weakness in all extremities , and bilaterally diminished tendon reflexes.
Neurological examination revealed severe dementia , frontal signs , and exaggerated bilateral tendon reflexes.
Neurological injuries such as stroke can lead to proprioceptive impairment.
Neurological signs and neuroimaging play a major role in clinical diagnosis.
Neurological symptoms contribute to identifying the pathological level.
Neurologic performance was assessed on days @number@ and @number@ after SAH.
Neurologic problems may include seizures of different types , such as febrile , generalized tonic-clonic , focal , and absence seizures.
Neurologists should be aware of PGD to be able to better consult at-risk families on their reproductive choices.
Neurologists should counsel patients on this therapeutic adjunct and provide specific recommendations when possible.
Neurologists such as August Knoblauch also discussed multiple levels of music processing , basing speculation on ideas about language processing.
Neurologists use alternative methods when technical difficulties require them , but these are not widely used by non-neurologists.
Neuromodulation is emerging as a therapeutic option in these patients.
Neuromuscular activation declined significantly within healthy older , but not in mobility-limited participants.
Neuromuscular activation rate was quantified as pre-movement time ( duration between EMG onset and movement onset ) and the rate of EMG rise.
Neuromuscular activation was quantified using surface electromyography and vastus lateralis single muscle fibers were studied to evaluate intrinsic muscle contractile properties.
Neuromuscular changes may be the critical early determinant of muscle power deficits with aging.
Neuronal active Caspase-6 ( Casp6 ) is associated with Alzheimer disease ( AD ) , cognitive impairment , and axonal degeneration.
Neuronal activity directly promotes the production and secretion of amyloid β ( Aβ ) .
Neuronal activity enhances the elaboration of newborn neurons as they integrate into the synaptic circuitry of the adult brain.
Neuronal activity , injury , and aging stress the nervous system , and lead to neuronal dysfunction and degeneration.
Neuronal growth and plasticity are no exception ; roles for lysine acetylation and deacetylation in brain function and dysfunction continue to be uncovered.
Neuronal inclusions of α-synuclein ( α-syn ) , termed Lewy bodies , are a hallmark of Parkinson disease ( PD ) .
Neuronal loss and gliosis were mild in the hypoglossal and facial nuclei.
Neuronal loss is closely associated with microglial activation and postmortem studies have indeed suggested that activated microglia may be present in the aging brain.
Neuronal loss is limited to restricted regions of the nervous system and is slight ( probably no more than @percent@ ) .
Neuronal overexpression of SMN significantly preserved locomotor function , rescued motor neurons , and attenuated astrogliosis in spinal cords of SOD1 ( G93A ) mice.
Neuronal pentraxin receptor ( NPR ) is a synaptic protein implicated in AMPA receptor trafficking at excitatory synapses.
Neurons are highly differentiated cells responsible for the conduction and transmission of information in the nervous system.
Neurons co-cultured with EKO glia showed the greatest viability with the lowest level of secreted TNF-α.
Neurons have significant homeostatic control of the essential physiological functions like synaptic excitability , gene expression and metabolic regulation.
Neurons that reenter the cell cycle die rather than divide , a phenomenon that is associated with neurodegeneration in Alzheimer's disease ( AD ) .
Neuropathic descriptors were associated with the greatest number of pain-associated conditions including osteoarthritis of the hand and knee.
Neuropathic pain is one of the most difficult consequences of spinal cord injury ( SCI ) .
Neuropathic pain ( NeP ) is a significant medical and socioeconomic burden with limited therapeutic options.
Neuropathies associated with diabetes , malignancy , and monoclonal gammopathies are even more common in these patients.
Neuropathological analysis showed extensive α-synuclein pathology with minimal phospho-tau pathology.
Neuropathological changes associated with Alzheimer's disease ( AD ) precede symptom onset by more than a decade.
Neuropathological diagnosis is essential in neurological disorders.
Neuropathological evaluation confirmed Alzheimer's disease , with moderate to severe amyloid angiopathy.
Neuropathological findings showed only a single neuritic plaque and neurofibrillary degeneration consistent with normal aging but not AD.
Neuropathological hallmarks of Alzheimer's disease ( AD ) include tangles ( NFT ) and beta amyloid ( Aβ ) plaques.
Neuropathological indicators and levels of synaptophysin were assessed and correlated with clinical measurements of cognition and dementia severity.
Neuropathological studies show that a neuroinflammatory response parallels the early stages of Alzheimer's disease ( AD ) .
Neuropathological variables and brain weight contributed approximately a third to half of the explained variance in different cognitive domains.
Neuropathological variables examined included total and regional LTS and plaque and tangle densities.
Neuropathologic diagnosis followed current consensus criteria.
Neuropathologic diagnosis was the gold standard.
Neuropathologic examinations were performed using immunohistochemistry and following internationally accepted criteria.
Neuropathology and structural damage in the LC appears to be one of the earliest changes.
Neuropathology data are available for the subset of participants who died.
Neuropathology of a case of Shiga pedigree with proximal-dominant hereditary motor and sensory neuropathy ( HMSN-P ) is reported.
Neuropathology of @number@ consecutive brain donations assessed degenerative and vascular pathologies.
Neuropathology suggests an important role for the locus coeruleus ( LC ) in Alzheimer's disease ( AD ) pathophysiology.
Neuropathy was diagnosed if the vibratory perception threshold of the big toe using biothesiometry was ≥ @date@ .
Neuropep-1 injection also significantly rescues the spatial learning and memory deficits of 3xTg-AD mice compared with vehicle-treated control group.
Neuropep-1 protects cultured neurons against oligomeric Aβ1-42 , , and glutamate-induced neuronal cell death.
Neuropep-1 treatment markedly increases hippocampal and cortical BDNF levels.
Neuropeptides are widely distributed in brain regions responsible for learning and memory processes with special emphasis on the hippocampus , amygdala and the basal forebrain.
Neuropeptides coreleased with small molecule neurotransmitters in autonomic nerves do not usually act as cotransmitters but rather as prejunctional neuromodulators or trophic factors.
Neurophysiologically , aging attenuates evoked responses including the mismatch negativity ( MMN ) .
Neurophysiologically , intelligence is considered as a complex capacity that is dependent on a global cognitive network rather than isolated brain areas.
Neurophysiological techniques have been scarcely involved in such debate , but nonlinear analysis methods may contribute to it.
Neuroplasticity can be conceptualized as an intrinsic property of the brain that enables modification of function and structure in response to environmental demands.
Neuroplasticity involves molecular and structural changes in central nervous system ( CNS ) throughout life.
Neuroplasticity occurs with many variations , in many forms , and in many contexts.
Neuroplastic strengthening of synapses is believed to serve as a critical mechanism underlying learning , memory , and other cognitive functions.
Neuroprotective effects of phytoestrogen compounds ( found in soy ) have been demonstrated in animal research and cell culture studies.
Neuroprotective potential evaluated in an Alzheimer's disease cell model showed that the toxicity of the β-amyloid can be significantly modulated by FPP.
Neuropsychiatric behaviors were assessed using @number@ behaviors derived from standard measures.
Neuropsychiatric behaviours occur frequently in Alzheimer's disease and other dementias and are thought to arise from the neurodegenerative process.
Neuropsychiatric symptoms , including depression , cognitive impairment , and substance abuse , are very common in individuals infected with HIV.
Neuropsychiatric symptoms ( NPS ) increased with increasing comorbidity burden in two out of three studies investigating NPS.
Neuropsychiatric symptoms were assessed using the Neuropsychiatric Inventory.
Neuropsychiatric symptoms were determined at baseline using the Neuropsychiatric Inventory Questionnaire.
Neuropsychologia , @number@ 1165-1170 , @number@ ] .
Neuropsychologia , @number@ 218-229 , @number@ ] .
Neuropsychological and clinical assessments were also carried out.
Neuropsychological and functional evaluations were performed at baseline , after the initial training phase , and after the booster training phase.
Neuropsychological and neuropsychiatric evaluations for depression and executive functions were performed 12-20 weeks after the index stroke.
Neuropsychological examination and testing in real-space human analog of the Morris Water Maze were administered.
Neuropsychological features were those expected for age and education based on Italian normative values.
Neuropsychological , functional , and diagnostic assessments were carried out at baseline and again at 4-year follow-up.
Neuropsychological or cognitive rehabilitation has undergone a considerable theoretical and practical development as a specialised field of research and clinical application in its own right.
Neuropsychological outcomes after RES in this population need further evaluation.
Neuropsychological outcome was significantly moderately correlated with morphine exposure in only two subtests , and children performed in general ' average ' by Dutch norms.
Neuropsychological scores that were detrended with the regression models and the behavioral symptoms of the EO-FTD and LO-FTD groups were compared.
Neuropsychological studies focused on brain-damaged patients have explored several aspects of the present , but few studies have examined the subjective aspect of the phenomenon.
Neuropsychological symptoms are observed prior to the decrease in Zn²⁺ signal in the hippocampus under zinc deficiency.
Neuropsychological test batteries revealed a significant unfavourable effect of use of drugs with anticholinergic activity on episodic verbal memory.
Neuropsychological testing will require extensive batteries to maximize utility.
Neuropsychological tests can accurately predict progression to all-cause dementia within @number@ years of diagnosis in a large community-based sample of non-demented participants.
Neurorestorative approaches through neurotrophin or cell therapy also represent a minor avenue in AD research.
Neurosci.
NEUROSCI BIOBEHAV REV XXX-XXX , @number@.- Childhood adversity is among the most potent risk factors for developing mood and anxiety disorders later in life.
Neurosurgeons are advised to be aware of this anatomical relation while operating around SSS.
Neurosurgical intervention for subdural hematoma decreased from @percent@ in @number@ to @percent@ in @number@ ( p < @number@ ) .
Neurosyphilis can present with psychiatric symptoms.
Neurotechnology is the emerging field that brings together the development of technologies to study the brain and devices that improve and repair brain function.
Neuroticism and event centrality also emerged as robust predictors of PTSD symptom severity.
Neuroticism and openness to experience decreased as people aged.
Neuroticism , but not conscientiousness , was associated with mortality risk , with a small-effect size.
Neuroticism did not differ between the two birth cohorts.
Neuroticism levels remained unchanged , suggesting this trait may be less influenced by environmental factors than the other traits studied.
Neuroticism may moderate the MFQ-amyloid-β association such that it is observed in the context of higher trait neuroticism.
Neuroticism moderated this association such that only high neuroticism individuals showed the predicted pattern of high complaint-high amyloid-β association.
Neuroticism traits from the NEO PI-R included anxiety , depression , anger-hostility , self-consciousness , impulsivity , and VS.
Neuroticism was assessed by Eysenck Personality Questionnaire ( EPQ ) and externality by Locus of Control of Behaviour.
Neuroticism was related to lower SWB and fewer positively experienced activities.
Neurotoxic effects observed in animals include histologic evidence for apoptotic neuronal cell death and subsequent learning and memory impairment.
Neurotoxin from the CBFC26 strain ( NTC ) is a recently developed botulinum toxin type A product manufactured through refined procedures.
Neurotransmission by biogenic monoamines is important for brain function.
Neurotransmitters are essential neurochemicals that maintain synaptic and cognitive functions in mammals , including humans , by sending signals across pre- to post-synaptic neurons.
Neurotrophic factors ( NTFs ) emerged as promising disease-modifying agents in PD and are currently under clinical development.
Neurotrophins , activating the PI3K / Akt signaling pathway , control neuronal survival and plasticity.
Neurotrophins are important neurotrophic factors involved in the survival , differentiation and function of a wide variety of neuron populations.
Neurotrophins are involved in muscle innervation and differentiation of neuromuscular junctions ( NMJs ) .
Neurotropic viruses remain dormant in sensory neurons for years , but upon reactivation , they can produce multiple disease states including pain symptoms.
Neurourol.
Neurourol.
Neurourol.
NeuroX data ( @number@ PD cases and @number@ controls ) were used for replication.
Neutral density filters were used to extend the luminance range of the CRT.
Neutralization of endogenous carboxyalkylpyrroles impaired wound healing and tissue revascularization and diminished tumour angiogenesis.
Neutralization of α5β1 confirmed that this integrin was indispensable for CAR expression.
Neutralizing antibodies to the identified chemokines reduced macrophage / monocyte chemoattraction.
Neutron activation analysis was used to determine the fluorine levels in these ex vivo samples.
Neutropenia was recorded in @number@ % of the patients.
Neutrophil activation is associated with the development of organ injury after trauma-hemorrhagic shock.
Neutrophil chemotactic activity was evaluated using migration assays.
Neutrophil function and stress hormone levels were preserved in the stressed in both age groups.
Neutrophil gelatinase-associated lipocalin ( NGAL ) has been recently proven useful in the quantitation of chronic kidney disease ( CKD ) .
Neutrophil-mediated production of interleukin-1β ( IL-1β ) drives gouty flares that cause joint destruction , intense pain , and fever.
Neutrophil-phagocytic and neutrophil-sterilizing activities were not associated with any variables.
Neutrophil phagocytosis of Escherichia coli ( E. coli ) and stimulated superoxide production were assessed.
Neutrophils and macrophages represent the first line of defence yet their ability to phagocytose pathogens decrease with aging.
Neutrophils are potent cells capable of degrading elastic fibers and collagen fibers and are probably important players in the pathophysiology of photoaging.
Neutrophils were analyzed for CD18 expression , stimulated oxidative burst , apoptosis , and IL-10.
Never-married smokers were less likely to be hardcore smokers than married ones ( odds ratio @number@ @percent@ CI , @number@.66-0.96 ) .
Never or seldom experiencing loneliness was a strong predictor for good SRH.
Nevertheless a choroidal thinning may be identified in the more advanced stages of the disease.
Nevertheless , after four weeks aging , more hydrophobic agent ( cardanol ) induced the highest resistance against water biodegradation.
Nevertheless , a full understanding of the role of mitochondrial bioenergetics through differentiation is still lacking.
Nevertheless , age effects were also observed in the retrospective component which thus contributed to the prospective memory performance differences between the age groups.
Nevertheless , a genetic diagnosis remains unavailable for many patients.
Nevertheless , ALA does not prevent AF recurrence after an ablative treatment.
Nevertheless , also these mice showed oxidative alterations in the brain.
Nevertheless , Alu methylation levels also vary among young individuals.
Nevertheless , a more strict recently proposed measurement , the conditional probability for recall given recognition , yielded significant age differences in all instances.
Nevertheless , an increased age-related vulnerability can be observed , occurring earlier than in the general population.
Nevertheless , AON Casp6 activity reflects that of the entorhinal cortex.
Nevertheless , a reduction of both was reported without compromising the oncological result.
Nevertheless , a small number of investigations studied the outcome of major hepatectomy in the population over @number@ years of age.
Nevertheless , available data allow to postulate that enrichment of diet in natural anti-glycating agents may attenuate glycation and , in consequence , ageing.
Nevertheless , before widespread use and application to lower risk patients the results of randomized studies are mandatory.
Nevertheless , building partnerships required time , effort , and resources for both researchers and local organizations.
Nevertheless , children exhibited normal LV filling due to higher diastolic radial and longitudinal strain rates.
Nevertheless , clinical assessment procedures need to be refined to improve the identification of pre-dementia individuals.
Nevertheless , common cosmetic procedures can be used in skin of color to treat the signs of aging.
Nevertheless , comprehensive skin tightening involves both dermal and hypodermal collagen remodeling.
Nevertheless , confirmation in additional study populations is needed.
Nevertheless , conjunctivitis might be the only sign of this sexually transmitted infection.
Nevertheless , contribution of co-stimulatory molecules to T-cell exhaustion in cancer remains to be better defined.
Nevertheless , councelling of older men seeking paternity should be patient-oriented and weigh statistical probabilities against the right for individual life-planning.
Nevertheless , despite intensive effort to access the physiopathological pathways of the disease , it remains poorly understood.
Nevertheless , drugs lowering blood pressure might differ in their effects on structure and function of the arterial walls.
Nevertheless emotional factors are still linked to disease states and morbidity ; for example , depression is a risk factor for mortality following myocardial infarction.
Nevertheless , emotion also recruits attention to process information , thereby disrupting short-term memory when tasks involve high attentional resources.
Nevertheless , etiology and early diagnosis of the disorders are still elusive.
Nevertheless , every patient preferred a transverse incision along a wrinkle line.
Nevertheless , few studies have focused on elucidating the pathophysiological mechanisms in the aged bladder.
Nevertheless , few studies so far have evaluated pelvic floor muscle function in postmenopausal women with dyspareunia.
Nevertheless , final adult height did not change significantly over the @number@ years.
Nevertheless , findings have been inconsistent across studies.
Nevertheless , for the majority of patients who receive a diagnosis of ALS , the role played by genetics is unclear.
Nevertheless , further analyses reveal an age variation in the relationship between volunteering and trajectories of depression.
Nevertheless , further trials are needed in order to confirm such considerations.
Nevertheless , germline DNA appears to remain sufficiently pristine to maintain fairly stable phenotypes over many generations.
Nevertheless , health care costs in the last years of life are still interesting , but for a different reason than is widely believed.
Nevertheless , heart failure in the elderly is commonly under-diagnosed , because dyspnoea and fatigue are often attributed to the natural process of aging.
Nevertheless , higher results than reference values were obtained on both body strength tests and aerobic endurance , specifically in men.
Nevertheless in the whole process participates also others exogenous and endogenous factors.
Nevertheless , intramuscular electroporation is the most common delivery method for ECTM vaccination.
Nevertheless , involvement of p38 in female reproductive aging is uncertain.
Nevertheless , it does clearly show that sensitivity to topical medicaments increases with age.
Nevertheless , it has been suggested that telomeres may play a role in the development of many aging-related diseases.
Nevertheless , it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon.
Nevertheless , it is instructive to look back at the origins of this important mutation.
Nevertheless , it is not clear whether advanced age itself increases surgical risk or additional age-independent variables are associated with higher operative morbidity.
Nevertheless , it is not uncommon to overlook the possible effects of sensory impairment ( s ) on test scores.
Nevertheless it is possible that some older women with early breast cancer can be spared too aggressive treatments.
Nevertheless , it is still unclear if NHPs have human-like age-associated changes in Aβ and tau protein in cerebrospinal fluid.
Nevertheless , it is unknown whether these two proteins directly interact in cells , and how they mediate their function.
Nevertheless , it may be that adaptation during a more complex task like gait is compromised by aging.
Nevertheless , it represents one starting platform for understanding cell biology of lifespan in relation to the metabolic syndrome.
Nevertheless , its association with some negative clinical impacts is well known and widely documented in the literature.
Nevertheless , lipid-lowering agents remain an integral component of the overall strategy to reduce atherogenic burden in older adults.
Nevertheless , little is known about the changes that phospholipids undergo during normal adult aging.
Nevertheless , liver resection in elderly patients is performed less often after PVO and carries a higher risk of liver failure.
Nevertheless , malnutrition rates continue to be unacceptably high.
Nevertheless , many positive indications have been reported with mammals , so it is reasonable to advocate for the conduct of more definitive clinical studies.
Nevertheless , many questions remain regarding adult neurogenesis in other brain regions and particularly in humans , where standard birth-dating methods are not generally feasible.
Nevertheless , many reasons restrict us from using oocyte donation in women with implantation failure.
Nevertheless , measurement of lifespan , as a surrogate for biological aging , remains among the most frequently used assays in aging research.
Nevertheless , mild FOXO3 activity also protects nigral neurons against the accumulation of human α-synuclein , albeit to a lesser extent.
Nevertheless , most organisms maintain healthy neurons throughout life , implying the existence of active maintenance mechanisms.
Nevertheless , music is unique in its powerful ability to elicit both memories and emotions.
Nevertheless , normal HSC aging is associated with a noticeable decline in regenerative potential and possible changes in other functions.
Nevertheless , numerous minimally invasive treatment alternatives are available that are comparable in effectiveness to TURP , with significantly less morbidity.
Nevertheless , older patients may be particularly vulnerable to circulatory or ischemic insults of the kidneys.
Nevertheless , osteoporosis in old age continues to be underdiagnosed and undertreated.
Nevertheless , overestimation of 5- and 10-year cumulative numbers of expected CRC deaths is still as high as 60-70% and 20-30% , respectively.
Nevertheless , over time , and particularly during old age , SASP might stimulate proliferation and premalignant cell transformation.
Nevertheless , partial - and even negative - models can increase knowledge of disease mechanisms.
Nevertheless , perceptual and affective responses were similar for all age groups.
Nevertheless , previous research findings , especially from anthropology , suggested the importance of social relations in the achievement of positive outcomes.
Nevertheless , quantitative research has shown minimal increase in participation in activities that benefit overall health.
Nevertheless , research regarding approaches to the male cosmetic patient is scarce.
Nevertheless , retrospective reports at up to @number@ y give credible outcomes for estimations of feeding pattern at @number@ mo of age.
Nevertheless , satellite cell activation upon exercise seems unequivocally together with adequate nutrition to be the most effective countermeasure for sarcopenia and sarcopenic obesity.
Nevertheless , sensory acuity has to be taken into account as a potential confounding factor in perceptually demanding visual attention tasks.
Nevertheless , several reports suggest that neurons maintain the MVA pathway active , even with sustained cholesterol supply by astrocytes.
Nevertheless , several terms have been used as synonymous : healthy , active , productive , optimal , positive aging.
Nevertheless , similar numbers of studies had negative results for each of these endpoints.
Nevertheless , sleep restriction produced a greater increase in MSLT-measured sleepiness in younger participants.
Nevertheless , some recent behavioral , endocrinological and neuroimaging studies may provide new insights into the discussion.
Nevertheless , some studies suggest that IIV relates more strongly than mean level of performance to the quality of white matter ( WM ) .
Nevertheless , statistical power of all measures benefits from smoothing.
Nevertheless , studies measuring telomere length ( TL ) in patients with BD compared to healthy controls have provided mixed results.
Nevertheless , studies of effects of nutrients or single foods on ageing often show inconsistent results and ignore the overall framework of dietary habits.
Nevertheless , study size expectations were met through an adaptive approach that suggests a potential effect of the economy on health and well-being.
Nevertheless , the approach may serve as a valuable alternative or addition in exceptional cases.
Nevertheless , the association of incidental physical activity ( IPA ) with health and cognition during aging has not been studied.
Nevertheless , the cell-intrinsic mechanism of this clock is present in most cells of the body.
Nevertheless , the compounds may also affect the auditory and vestibular ganglion neurons.
Nevertheless , the data suggest that the master athletes ' high level of physical activity may protect motoneurons.
Nevertheless , the efficacy of L-carnitine supplementation on frailty status has not been documented.
Nevertheless , the elderly can benefit from alteplase after they experience an acute ischemic stroke.
Nevertheless , the essence of stem cell research is to understand how tissues are maintained during adult life.
Nevertheless , the few available studies indicate paternal smoking and maternal overweight , obesity and diabetes to be associated with increased risks.
Nevertheless , the field faces several complex research and clinical challenges.
Nevertheless , the field of cardiac electrophysiology has , auspiciously , greatly matured over the past @number@ decades.
Nevertheless , the findings that genetic or diet interventions can increase lifespan in evolutionarily diverse organisms indicate that mortality can be postponed.
Nevertheless , the frailty phenotype is the most widely used and presents a characterized pathophysiologic background.
Nevertheless , the high poverty levels among elderly immigrants are mitigated by financial assistance from their kin.
Nevertheless , the imaging techniques were sensitive enough to detect subtle grey matter changes not normally evident until much later in the disease.
Nevertheless , the impact of RNF8-mediated ubiquitination on DNA repair remains to be elucidated.
Nevertheless , the individual benefit of transplanting elderly patients has to be balanced against the corresponding increase in the number of patients awaiting grafts.
Nevertheless , the intervention with hearing aids reverses that perception.
Nevertheless , their life expectancy is still shortened by more than two decades compared to the general population.
Nevertheless , the knowledge gathered so far at the systemic level is clearly insufficient.
Nevertheless , the lack of an univocal operational definition for the two conditions has so far hampered their clinical implementation.
Nevertheless , the lack of effect in @percent@ of this male cohort shows that vitamin E is no panacea for extending life expectancy.
Nevertheless , the LDR group showed similar values to S ones in muscle mass.
Nevertheless , the likelihood of taking sick leave is increased.
Nevertheless , the mentioned results apply only to the plain PA - longevity relation.
Nevertheless , themes of acceptance and satisfaction dominated our findings , as did reciprocity and exchange.
Nevertheless , the negative correlation between RSFC and WM performance hints at limited cognitive reserve capacity in lower performing older adults.
Nevertheless , the overall number of cases is predicted to increase.
Nevertheless , the pharmacokinetic effects of @number@ major pulmonary vasodilators appear to be similar in children and adults with PAH.
Nevertheless , the precise extent of neurodegeneration throughout the central nervous system is not fully understood.
Nevertheless , the precise nature of the biochemical mechanisms of metal involvement in NDs is still largely unknown.
Nevertheless , the present findings are reassuring for reproductive health prospects in women with type @number@ diabetes.
Nevertheless , the present model is too schematic to account for other higher order aberrations , such as tetrafoil , also present in real eyes.
Nevertheless , the principles of management of type @number@ diabetes in the elderly are not different from those in middle-aged patients.
Nevertheless , the prospective potential support ratio usually focuses on the current mortality schedule , or period life expectancy.
Nevertheless , the ratio VEGF / KDR was significantly higher in the aged individuals.
Nevertheless , there are few studies and clinical guidelines that address these issues.
Nevertheless , there are inconsistencies and gaps in the evidence , and additional research is needed to define the most appropriate therapies for MetS.
Nevertheless , the reason why supercomplexes exist remains an enigma.
Nevertheless , there has been little neurological investigation into PFC activity during this test.
Nevertheless , there is debate on the dose-response relationship of exercise and cardiovascular disease outcomes and whether high volumes of exercise may accelerate coronary atherosclerosis.
Nevertheless , there is no consensus on which properties these products should possess.
Nevertheless , there is no established conclusion on the way aging affects phase-locking measures of ASSRs in healthy subjects.
Nevertheless , the relation between CD4 : 8 ratio and functional outcome has rarely been investigated.
Nevertheless , the relation of cholesterol to mild cognitive impairment ( MCI ) , influence of APOE genotype and its changes in lifespan is controversial.
Nevertheless , the relationships identified in epidemiological studies can offer practical solutions to disease prevention.
Nevertheless , the role of SIRT1 in the pathogenesis of osteoarthritis ( OA ) is still unknown.
Nevertheless , the role of tumor suppressor p53 in the mechanism action of fucoidan remains unclear.
Nevertheless , the scientific interest is now focusing on novel modified nucleotides with potential regulatory roles , such as 5-hydroxymethylcytosine.
Nevertheless , these cell types are marked by distinct gene expression signatures.
Nevertheless , these solutions have no adverse effect on adhesion to tooth structure.
Nevertheless , the sex-related differences are possibly compatible with the historical observation of better performance in visual-spatial tasks in males than females.
Nevertheless , the specific role of cellular aging in this process is still unclear.
Nevertheless , the tuning of cellular metabolism towards maximal survival is the molecular basis of longevity.
Nevertheless , the usefulness of MQI to assess physical function is limited by whether it is reflective of muscle qualitative changes to an intervention.
Nevertheless , they have largely been neglected in later research perhaps due to a lack of suitable analytical tools.
Nevertheless , they have provided a proof of concept that motor symptoms could be improved by cell transplantation.
Nevertheless , the young adults benefited from the HS1 practice and broke gaze anchoring even when the second pointing was included in HS1S2.
Nevertheless , they represent promising tools in the future , enhancing methods of therapeutic cloning and infertility treatment.
Nevertheless , they were as accurate as young subjects for upright walkers during training , in which no noise was added to the display.
Nevertheless , this adaptation is limited.
Nevertheless , those elderly patients who will benefit from surgery must be critically selected.
Nevertheless , to what extend case management programs can lead to an improvement of care and expenditures savings is not known.
Nevertheless , ultrasound biometry is still required for cases with dense posterior subcapsular cataract.
Nevertheless , understanding the dynamics of this cultural ideal may enhance our knowledge while developing an appreciation of the black woman's ability to age successfully.
Nevertheless , VAD implantation remains a high-risk procedure with in-hospital mortality rates reaching up to @percent@ post-procedure and requires intensive upkeep even after successful implantation.
Nevertheless , variability in these networks due to factors such as sex and aging is not fully understood.
Nevertheless , very limited data exist on the association between serum CZr and physical or functional status of very old people.
Nevertheless , well-designed RCTs with a larger sample size are required in the future.
Nevertheless , we predicted that older adults would reduce muscle activity and metabolic cost with motor adaptation , similar to young adults.
Nevertheless , when only the worst nostril of each participant was included in the analysis , aMCI patients outperformed their AD counterparts.
Nevertheless , WMI remains a global health problem and the most common cause of chronic neurological morbidity from cerebral palsy and diverse neurobehavioral disabilities.
New aesthetic indications have also developed , and there has been an increased utilization of combination therapies to combat the effects of global aging.
New and reinforced information about Australian nursing scholarship was revealed.
New assays and analytical tools have become available that start to unravel some of these mechanisms.
Newborn blood plasma demonstrates substantially higher adenosine-generating @number@'-NT and AP activity and lower adenosine-metabolizing ADA activity than adult plasma.
New Brunswick is one of the provinces most affected by the aging of the population.
New cancer cases are increasing steadily due to population aging , among other factors.
New cases of acute occupational poisoning mainly concentrated in small businesses.
New challenges must be met such as maternal phenylketonuria , long term effects of dietotherapy and the sequelae of untreated phenylketonuria in adulthood.
New clinical trials will examine the contemporary role of carotid revascularization relative to optimal medical therapy.
New CMR indices of tissue composition by using T1 mapping are sensitive to the presence of myocardial fibrosis.
New cohorts aging with disabilities will have more resources and more experience with integrated technologies than current elders.
New compounds have accordingly been developed and clinically tested , proving to yield a high contrast for tau deposits with high specificity.
New concept of heart-gut axis has a great potential for breakthroughs in the development of novel diagnostic and therapeutic approach for HF.
New data also indicate the potential of these processes to interact with and influence ageing in other tissues.
New data involve the development of a Musical Engagement Questionnaire especially designed for use with AD patients.
New data support the importance of prolonged cardiac monitoring for diagnosing occult atrial fibrillation.
New developments in the realm of skin rejuvenation such as phytotherapy are at an astounding increasing pace in the cosmeceutical market.
New directions for intervention programs , aiming to reduce burnout , should be examined.
New discoveries in HF neogenesis and low-level light therapy will undoubtedly have a role to play.
New discoveries related to this medicinal mushroom and its biological properties are frequently reported.
New drugs are being developed , and new combinations are investigated.
New drugs could be identified and disease mechanisms better understood by establishment of well-controlled cell model systems.
New efforts and resources are needed in clinical research for the complete evaluation of FA therapeutic potential in chronic diseases.
New elements emerged from the investigation in progress and revealed that the original cause was incorrect.
Newer AEDs have a lower potential for drug interactions and are reported to be better tolerated by the elderly than old-generation AEDs.
Newer agents may enable a higher proportion of patients at high risk of stroke to be treated with anticoagulants than is currently the case.
Newer imaging modalities , functional capacity testing and blood biomarkers have the potential to improve early detection of cardiotoxicity and reduce cardiovascular morbidity and mortality.
Newer options generally pose less risk of significant systemic toxicity and are better tolerated.
New evidence has shown that the lysosomal system might be a crossroad in which etiological factors in AD pathogenesis converge.
New evidence indicates that bona fide sirtuin substrate proteins form stable physical associations with their sirtuin regulator.
New evidence indicates that synaptic activity directly evokes the release of Aβ at the synapse.
New findings suggest that age related tissue changes themselves contribute significantly and are not just associated.
New fractures occurred in @number@ patient with stage @number@ CKD , but not in patients with stage @number@ CKD.
New functions for circRNAs are arising , including protein sequestration , transcriptional regulation , and potential functions in cancer.
New-generation quinolones , such as moxifloxacin , could be useful as eradication therapy , especially as rescue therapy.
New genetic factors explained @percent@ of the genetic variance in AUD at T2.
New genome-wide studies have elucidated the genome and epigenome of solid tumors and AML.
New graduates account for the highest numbers of nurses entering and exiting the profession.
New high-quality studies are needed to investigate the effect of SPT.
New histopathological findings and genetic etiologies have been discovered.
New hospital care models are patient-centered and encompass the concepts of departments to embrace the differentiated levels of care approach.
New human genetics technologies are continually in development and may lead to additional breakthroughs in human ageing in the near future.
New independent factors associated with under-recognition were identified.
New information on infectious diseases in older adults has become available in the past @number@ years.
New insight into the molecular mechanisms governing this metabolic reprogramming has implicated mammalian sirtuins as important regulators of cancer metabolism.
New insights in this field can lead to the identification of preventive strategies and better treatment of multimorbid patients.
New instruments are therefore needed for researchers to properly understand the health and disability of ageing populations.
New instruments were added to assess economic effects on retirement planning and the physical and emotional costs of caregiving responsibilities.
NEW KNOWLEDGE : Teenagers who choose to continue to tan were aware of the long-term health risks associated with ultra-violet over-exposure.
Newly arising spontaneous genetic alterations in commonly used strains may also lead to new and valuable mouse models of disease.
Newly derived methods of cardiovascular physics can help to find indicators for these health risks.
Newly developed electrochemical techniques for exploring melatonin availability in real-time promise to accelerate our understanding of GI melatonin in the years to come.
Newly developed products of the medical device category offer DNA repair function paired with high sun protection factor ( SPF ) UV protection.
Newly-diagnosed cancer patients aged @number@ years and over were recruited in the Segal Cancer Centre , Jewish General Hospital , Montreal , Canada.
Newly discovered influences on sirtuins and downstream factors indicate that melatonin has a role in mitochondrial biogenesis.
Newly discovered striatal neurogenesis - normally a lifelong process - determines the efficiency of nigrostriatal interaction.
Newly recognized factors contributing to neurocognitive impairments include aging and unanticipated side effects from cART.
New measures of aortic flow and the response of the left ventricle provide new insights into the treatment of patients with this condition.
New mechanisms have been put forth to explain earlier conflicting observations.
New medical conditions and recent widowhood were associated with newly screening for severe depression.
New members of this group include the cytosolic ATPase Get3 in yeast , the Escherichia coli protein RidA , and the mammalian protein α2-macroglobulin.
New meta-analyses do not show an efficacy in preventing invasive pneumococcal disease or death of all cause.
NEW METHOD : Dictionary learning and sparse coding allow for constructing improved cell representations using IF images.
New methods that pose fewer risks , such as film-forming solutions and photodynamic therapy , are emerging to treat skin and toenail infections.
New methods to provide care for older people recovering from surgery may reduce surgery-related complications.
NEW METHOD : The proposed approach distinguishes itself from previous automatic sleep staging methods by using three specially designed feature groups.
NEW METHOD : To address these problems , we proposed an automatic LGN segmentation algorithm based on T1-weighted imaging.
New mitochondria contain their own genome with a modified genetic code that is highly conserved among mammals.
New models of health care delivery are inevitable.
New models of palliative care may be required to address this.
New models of sensory assessment that take account of hearing and vision are needed to support early detection and timely rehabilitation for DSI.
New molecular techniques , coupled with increased understanding of estrogen in skin biology , will provide further opportunities to develop estrogen receptor-targeted therapeutics.
New neurons are continuously generated and added to neural circuits in the adult brain.
New nonimmortalized fibroblast-like cell line SC6-MSC has been obtained from a line of human embryonic stem cells ( ESC ) SC6.
NEW & NOTEWORTHY : The present study is the first to demonstrate that caveolin-1 can regulate DISC1 expression in neuronal models.
New observations suggest an additional function for telomeres , namely in gene silencing via formation of long-range chromatin interactions.
New onset ( incident ) delirium was diagnosed by daily research staff assessments using the Confusion Assessment Method and Delirium Rating Scale-Revised-98.
New-onset seizures in elderly patients are typically symptomatic or cryptogenic partial seizures that require long-term treatment.
New or adapted tools are likely needed in such patients but remain to be studied.
New pathogenetic conditions and their tests are described ( sirtuines , telomere length , heart rate variability ) .
New pathophysiological models incorporate structural brain changes with established changes in neurotransmitter function.
New patients completed a self-administered intake form , including six brief sexual activity and function items.
New pharmacological compounds targeting this response are emerging as promising treatment strategies.
New phylogenetical , physiological , and clinical implications are discussed.
New potential indications included sarcopaenia , anorexia of ageing , frailty , mobility disability and reduced functional capacity secondary to hospitalization.
New preparations have been developed for possible enhancement of efficiency , tolerability , and pleiotropic nonglycemic effects.
New radiotracers are being developed and promise to expand further the list of indications for PET.
New research criteria that recognise early presentations of PSP and operationalise diagnosis of the full spectrum of clinical phenotypes have been reported.
New retinoids and formulations specifically optimized to improve cutaneous tolerability have been introduced.
New scenarios should be assessed and proposed from both the management and clinical perspectives.
New sCJD MRI criteria are proposed.
Newspaper health stories often originate with news releases from health organizations.
Newspapers in rural versus suburban and urban areas were more likely to publish health news stories , as were midsized newspapers.
New steroids , klyflaccisteroids K-M ( 1-3 ) , were isolated from a soft coral Klyxum flaccidum.
New strategies for treating CHF are needed.
New strategies must be devised to ensure efficient access to emergency theatres , investment in such services is likely to be financially and clinically beneficial.
New studies are identifying BBB-specific transport pathways that tightly regulate the entry and exit of molecules to and from the brain.
New studies should address the causality and temporality of this relationship.
New studies should take advantage of the experience obtained from longitudinal studies on aging already conducted.
New tDMRs in genes are being searched for consistently to serve as novel markers in forensic DNA analysis.
New techniques that might improve some of these points are in development and will be reviewed in this article.
New technologies allow the non-invasive assessement of various biomechanical and biological aspects of arterial ageing.
New technologies and more aggressive screening may also change the equation.
New technology for bone age determination includes computer-automated readings and assessments obtained from alternative imaging modalities.
New technology is constantly being developed to improve cosmesis , shorten recovery and reduce risk.
New therapeutic alternatives targeting these proteins and repairing related neuronal changes are under development for the treatment of ischemic brain consequences including memory loss prevention.
New therapeutic approaches are desperately needed.
New therapeutic approaches are warranted , aiming to at least delay and possibly reverse disease progression.
New therapeutic approaches based on these pathophysiological mechanisms are warranted for the treatment of anorexia in cancer patients , especially elderly ones.
New thinking about AD pathogenesis and novel , effective treatments are urgently needed.
New treatment strategy is expected for targeting age-associated diseases against the decreased level of sex hormones.
New trends in reproductive medicine have influenced the evaluation of andrological patients in recent years.
New users were at higher risk than continuing users.
New VESC at the age of @number@ appeared in @number@ of the @number@
New York City has many HCV-infected residents and has developed a public health approach to controlling the HCV epidemic.
Next , a conjunction analysis identified associations between personality scores and GM volumes that were replicable across time , also using cluster-level Family-Wise-Error correction.
Next , amygdalar and hippocampal volumes were regressed against Child Behavior Checklist Anxious / Depressed ( A / D ) scores.
Next , a range of studies were completed to support the pathogenicity of this finding.
Next-generation RNA sequencing and DNA methylation data were generated using frozen tissue from the dorsolateral prefrontal cortex.
Next-generation sequencing revealed a broad spectrum of putative pathogenic mtDNA point mutations affecting NADH dehydrogenase and COX genes as well as regulatory elements of mtDNA.
Next-generation sequencing technology allows simultaneous analysis of multiple susceptibility genes for clinical cancer genetics.
Next , nuanced patterns were constructed using quartile splits followed by one-way analysis of variance and post hoc subgroup comparisons.
Next , participants performed another go / nogo task.
Next , percent correct depth direction was determined as a function of disparity.
Next , seeking evidence of a critical decline in gait , we selected @number@ parameters : total double support , stride time and velocity.
Next steps include seeking input and endorsement from stakeholders in the broader medical education community.
Next the implications for disorders of cognition , such as Alzheimer's disease , will be discussed.
Next , the MNA was applied by the attending nursing staff who was blinded to the results of the first MNA.
Next , they were reviewed by industry representatives and members of the interRAI network.
Next to age-associated physiologic changes , diseases like diabetes or inflammatory , neurological , malignant and endocrine disorders may contribute to the development of sarcopenia.
Next , to clarify whether RCAN1 regulates the branching of blood vessels in vivo , we injected RCAN1 mRNA into fertilized Xenopus laevis eggs.
Next to non-pathological inflammatory processes , the review presents aspects of inflammation in the aging retina , AMD , glaucoma , uveitis and diabetic retinopathy.
Next to the amount of fibrosis , we offer data suggesting that collagen texture too plays a role in conduction slowing and arrhythmia vulnerability.
Next to the base case analysis , univariate probabilistic sensitivity and scenario analyses were performed.
Next to vitamin D deficiency , also higher levels of 25 ( OH ) D have been reported to be associated with increased cardiovascular risk.
Next , using standard regression-based moderator and mediator analyses , we systematically tested whether the identified covariates would significantly alter observed T2D-cognition relationships.
Next , we analyzed sodium channel α-subunit levels in brains of BACE1-null mice at @number@ and @number@ months of age.
Next , we confirmed that curcumin increased mild ER stress and osteoblast differentiation similar to BMP2 in C3H10T1 / 2 mesenchymal stem cells.
Next , we demonstrated that this could not be explained by augmented extracellular ATP hydrolysis in whole blood with age.
Next , we describe the actual and potential impact of autophagy on microglial phagocytic and inflammatory function.
Next , we evaluated association of AMD with genes in AD-related pathways identified by canonical pathway analysis of AD-associated genes.
Next , we genotyped these variants in another @number@ PD cases and @number@ control subjects.
Next , we intend to unravel the nature-nurture contribution to placental telomere length by estimating the heritability of placental telomere length.
Next , we outline how defects in peroxisome biogenesis may directly impact cellular pathways involved in the development of disease.
Next , we performed surface biotinylation studies in acutely dissociated hippocampal slices from BACE1-null mice.
Next we provide an overview of the available studies and recommendations from ATP III.
Next , we review work that motivated our focus on axonal diameter , and explain the relationships between transport and cytoskeleton within the axon.
Next , we tested whether methyl-β-cyclodextrin ( MβCD ) as a chemical Cav-1 inhibitor could be developed as a collagen-modulating agent in the skin.
NEXus has continued to grow since its inception in @number@
NF1 group performed worse than control group on a global cognitive impairment task , verbal working memory , and visuospatial functioning.
NF-E2-related factor @number@ ( Nrf2 ) is a CNC-bZIP transcription factor which regulates the basal and inducible expression of a wide array of antioxidant genes.
NF jiggle was significantly higher in the TA compared to VM ( P < 0.05 ) .
NFL appears to be a sensitive biomarker of subclinical and clinical brain injury in HIV and warrants further assessment for broader clinical use.
NFL correlates with neopterin and albumin ratio , suggesting an association between axonal injury , neuroinflammation and blood-brain barrier permeability.
NfL in NC2 was similar to NC.
NFL in persons who reported taking eye drops for high intraocular pressure was thinner compared to those not taking drops.
NFL predicted hippocampal atrophy rate independently of age , β-amyloid 1-42 , and P-tau.
NFTs and Aβ plaques have been widely implicated and described in normal aging.
NFTs are one of the hallmarks of Alzheimer disease and other tauphaties.
NF-κB activation induced TNF-α secretion and JNK activation to mediate death of senescent cells in a caspase- and JNK-dependent manner.
NFκB activation requires Lys63-linked ( K63-linked ) ubiquitination of upstream proteins such as NEMO or TAK1 , forming molecular complexes with membrane-bound receptors.
NF-κB activation triggers beta-cell apoptosis , and both GABA and Klotho suppress this pathway.
NF-κB and phosphorylated Erk1 / 2 ( p-Erk1 / 2 ) was significantly down-regulated in Gnaq-SY5Y cells.
NFκB compared to ß-actin protein abundance was estimated by Western blotting and cell volume from forward scatter.
NF-κB increases inflammation , carcinogenesis and metastatic potential in the prostate.
NF-κB is one of the major transcription factors mediating the induction of E-selectin and VCAM-1 expression , adhesion molecules responsible for leucocyte attachment to EC.
NFκB signaling is activated downstream of JAK2V617F receptor and directly induces CXCL10 expression.
NF-κB signaling is activated in cachectic , but not in sarcopenic , muscle.
NF-κB signaling made no contribution to the phenotype observed.
NG-094 is thus a promising candidate for tests on mammalian models of polyQ and other protein conformational diseases.
NG-094 significantly ameliorated polyQ-mediated animal paralysis , reduced the number of Q35-YFP aggregates and delayed polyQ-dependent acceleration of aging.
NGAL levels were neither related with specific symptom profiles of depression nor with antidepressant drug use.
N-glycome was evaluated in serum glycoproteins.
N-glycosylation is an age-dependent process , identified as a biomarker for physiological aging ( GlycoAge Test ) .
NGN decoction works on LOH by acting on the axis.
NGR deamidation in Cp was associated with gain of integrin-binding function , intracellular signaling , and cell pro-adhesive activity.
NHANES 2001-2006 cross-sectional data among adults aged 20-85 y were analyzed ( n = 3008-9099 ) .
NHB and HISP had lower levels of Se than NHW and NHAS.
NHB had lower than expected survival for all insurance types.
NHDF cells that were treated with CSE after UVB irradiation exhibited higher procollagen type I production and lower levels of MMP-1 than untreated cells.
NHD may be the prototype of primary microglial disorders of the CNS or , as they have been coined , \ "microgliopathies \ ".
NHE-1 and AQP1 are mainly expressed in tissues of the cardiovascular system.
NHE1-ko abolished recovery from NH4Cl pre-pulse cellular acid loading while both NHE1 and CA9 knockout reduced resting pHi.
NHE1-ko significantly reduced tumor cell proliferation both in normoxia and hypoxia while CA9-ko dramatically reduced growth in hypoxic conditions.
NHEJ1-patients develop severe progressive lymphocytopenia and premature aging of hematopoietic stem cells ( HSCs ) at a young age.
NHEJ is a non-templated DNA repair process , in which DNA termini are directly ligated.
NHEJ kinetics were several-fold slower in hESCs and neural progenitors ( NPs ) than in astrocytes derived from hESCs.
NH length-of-stay and characteristics were reported in the total , long-stay , and short-stay residents.
NhTERT mRNA was markedly correlated with CD3 ( + ) T lymphocyte count and CD4 ( + ) / CD8 ( + ) ratio.
Nicaragua is a very low-income country entering a period of rapid aging with limited geriatric training for health care professionals.
NICE resource implications and commissioning support to implement these guidelines and improve dementia services have been recently published.
Niche availability provided by stromal cells is critical to thymus function.
Nickel and other cationic metals travel through waterways and bind to soils and sediments.
Nickel ions bound to hydrolysis products demonstrated an ability to generate ROS.
Nicotinamidases are generally efficient catalysts with steady state k ( cat ) values typically exceeding @number@ s ( @number@ ) .
Nicotinamidases are metabolic enzymes that hydrolyze nicotinamide to nicotinic acid.
Nicotinamide phosphoribosyltransferase is the rate-limiting enzyme that catalyzes the first step in the biosynthesis of nicotinamide adenine dinucleotide from nicotinamide.
Nicotinamide phosphoribosyltransferase ( NAMPT ) catalyzes the first reversible step in NAD biosynthesis and nicotinamide ( NAM ) salvage.
Nicotine seems to have , at the same time , positive , neuroprotective as well as negative , neurotoxic effects.
Nidogen-2 protein is also found in these BMs but with a weaker expression in the ILM.
Niemann-Pick type C ( NPC ) disease is a rare autosomal-recessively inherited lysosomal storage disorder caused by mutations in NPC1 ( @percent@ ) or NPC2.
Niemann-Pick Type C ( NPC ) disease is caused by a deficiency of either NPC1 or NPC2.
Nifedipine is a dihydropyridinic calcium antagonist which blocks muscular cells ' calcium channels , therefore inhibiting their contraction.
Nighttime behaviors were reported more frequently by caregivers for the bvFTD patients and strongly correlated with caregiver distress.
Nighttime dipping was calculated as the percentage decline in nighttime / daytime blood pressure.
Night-time sleep quality , day-time drowsiness and day-time napping behavior were assessed using a validated questionnaire.
Night work history ( ever / never ) from 1998-2002 was available from a subsample ( N = 320 ) .
NIHSS on the 1st day positively correlated with SPMSQ score and with BI on day @number@
NIID has been considered to be a heterogeneous disease because of the highly variable clinical manifestations , and ante-mortem diagnosis has been difficult.
Niigata University has the largest resource on neurodegenerative disorders.
Nilotinib decreased blood and brain cytokines and chemokines and increased CX3CL1.
Nine academic nurse leaders from BSN programs nationwide were interviewed in this grounded theory study.
Nine articles appeared with only one category label and were grouped as \ "others. \ "
Nine articles met our inclusion criteria and were assessed for this systematic review.
Nine chronic conditions were selected , and mood trajectories were measured with the Center of Epidemiological Studies-Depression scale.
Nine electronic literature databases were searched ; a total of @number@ abstracts were identified , but only @number@ satisfied the inclusion criteria.
Nine focus groups were conducted including a range of healthcare professions.
Nine guidelines demonstrated the maximum level of content regarding physical , psychological , and social care.
Nine healthy participants stood atop a moveable platform and received externally-triggered ( EXT ) and selftriggered ( SLF ) drop perturbations of the support surface.
Nine histologically confirmed GBM cases , 58-80 years old , were identified.
Nine hundred eighty-four participants in the National Alzheimer Coordinating Center cohort study who died and underwent autopsy and met inclusion and exclusion criteria.
Nine hundred fifty-six ( @percent@ ) respondents believed that there should be no absolute age cutoff at which neurosurgical practice is forced to end.
Nine-hundred twenty-eight respondents participated in the different phases of the process.
Nine included longitudinal IIV measures and @number@ predicted subsequent outcome ( cognitive decline or impairment , dementia , mortality ) from baseline IIV.
Nine inertial sensor modules were used to measure the body segmental kinematic characteristics of each subject in our experimental activities.
Nine left- and @number@ right-lateralized hubs were identified as peaks in the degree map from the graph of significantly lateralized connections.
Nine non-fixed cadaver heads in the age range between @number@ and @number@ years ( five female and four male ) were investigated.
Nine of @number@ sedentary seniors ( @number@.6±3 years ; @number@ male , @number@ female ) completed @number@ year of endurance training followed by repeat measurements.
Nine of the AFFs had their fractures fixed with an intramedullary ( IM ) nail.
Nine of them survived in the validation phase and were designated as frailty-associated loci.
Nine of the @number@ students in the intervention group had a greater interest in working with seniors after the program.
Nine older couples , where both partners had lived long lives with physical disabilities , were interviewed as dyads about mutual caregiving.
Nine other δ-related proteins were not confirmed by this ethnicity adjusted analysis.
Nine patients also underwent chemotherapy.
Nine points including the central point of the line were chosen in @number@.5-mm intervals to calculate CT.
Nine professional drivers competing in premier race categories ( e.g. Formula @number@ Porsche GT3 Cup Challenge ) completed the study.
Nine proteins were differentially expressed among the @number@ proteins identified using proteomic techniques.
Nine proteins were more abundant in the adipocytes isolated from old vs. young individuals.
Nine reports were identified from the search and were subject to further assessment.
Nine SNPs reached nominal significance with sclerostin.
Nine studies comprising @number@ participants , published between @number@ and @number@ met the inclusion criteria.
Nine studies failed to demonstrate efficacy on PF of the ICU survivors.
Nine studies involved young EA ( mean age ≤40 years ) while nine studies involved master EA ( mean age > 55 years ) .
Nine studies used feasible interventions , with an average small to moderate effect size.
Nine studies were included ( @number@ retrospective cohort and @number@ case-control ) enrolling @number@ MS patients ( @number@ with epilepsy ; @percent@ ) .
Nine subjects had improvements in urologic function.
Nine subjects ( @percent@ ) died within @number@ months , and all were frail.
Nine subjects with PD and eight controls performed wrist flexion / extension movements at maximal velocity and range of motion.
Nineteen articles met criteria.
Nineteen articles met the inclusion criteria.
Nineteen CN Aβ42 + and @number@ subjects with Aβ42 levels above @number@ pg / mL ( CN Aβ42- ) were included.
Nineteen control , @number@ aMCI , and @number@ AD participants completed an olfactory identification task and underwent PiB PET scanning.
Nineteen glycemic and @number@ erythrocytic variants were associated with HbA1c at genome-wide significance.
Nineteen had multiple ( ≥7 ) lesions.
Nineteen high-functioning adults with ASD , and age- and intelligence-matched TD controls performed verbatim recall of temporally manipulated sentences.
Nineteen intervention and @number@ observational studies from @number@ countries investigated factors at the resident , institutional , or policy level.
Nineteen mild cognitive impairment and @number@ Alzheimer's disease patients were recruited from the Dementia Clinic of the Seoul National University Hospital.
Nineteen of the @number@ patients were followed up also completed satisfaction questionnaires at one and three postoperative months.
Nineteen participants from two local community services centers were interviewed and six multidisciplinary meetings were attended for observation.
Nineteen participants had signs of mild or moderate VVA.
Nineteen participants ( @percent@ ) were diagnosed with mild cognitive impairment and the remainder had normal cognition.
Nineteen patients completed the study with a 3-month follow-up.
Nineteen patients had primary face lifts performed ; three patients were secondary cases.
Nineteen patients ( @number@ percent ) had volume loss in the midface and nasolabial groove regions.
Nineteen percent and @percent@ of patients in group E and group Y were discharge to rehabilitation facilities , respectively ( P = @number@ ) .
Nineteen percent of drivers sustained an UEI related to the airbag.
Nineteen percent of the cohort had one sensory impairment and @percent@ had multiple sensory impairments.
Nineteen percent of the community group met all six criteria on the successful aging score versus @percent@ of the schizophrenia group.
Nineteen showed high reliability coefficients.
Nineteen skulls had bone porosities in other areas.
Nineteen studies met our selection criteria and additional five studies reported self-reported hearing impairment.
Nineteen studies were assessed as being of \ "positive \ " and @number@ of \ "neutral \ " quality.
Nineteen subjects participated , eleven without ( C ) and eight with PD ( PD ) .
Nineteen trials were included , @number@ of them comparing exercise with an inactive control.
Nineteen women ( mean age = 56.79 , SD = 4.63 years ) referred from Boston-area community organizations and hospitals completed in-depth individual interviews.
Nineteen YAs and @number@ OAs overlearned a sequence of key presses.
Nineteen young and @number@ elderly subjects tracked a visual target presented as unpredictable smooth pursuit or saccadic displacements.
Nineteen young and @number@ older healthy adults were scanned during observing novel and familiar affective pictures while estimating their own subjectively experienced aroused levels.
Nine trials ( @number@ % ) specifically investigated breast cancer treatment in older patients.
Ninety-eight community-dwelling patients with schizophrenia ( mean age = 35.8years , S.D. = 10.1 ) participated in the study.
Ninety-eight percent of the children managed to complete all measures.
Ninety-five older adults were divided according to their educational attainment and their Information subtest score , and completed extensive neuropsychological assessment.
Ninety-five older persons without dementia underwent detailed clinical and cognitive evaluation and magnetic resonance imaging , including diffusion tensor imaging.
Ninety-five participants presented with mild parkinsonian signs at baseline.
Ninety-five percent ellipse area and sway velocity were calculated from the center of pressure displacement.
Ninety-five percent ellipse area was the same for both groups in all tests.
Ninety-five percent of all EPs demonstrated at least one type of abrasion on the stitches.
Ninety-five percent of surgeons performed only @number@ type of surgical procedure , and among those , @percent@ of surgeons performed only trapeziectomy with LRTI.
Ninety-five per cent were retained in the study at the six-month follow-up , and @number@ per cent at @number@ months.
Ninety-four children had unilateral spastic CP , @number@ bilateral spastic CP , and six had other forms of CP.
Ninety-four men presenting for infertility consecutively between the ages of @number@ and @number@ years were identified.
Ninety-four of @number@ screened positive.
Ninety-four papers were included , of which study methods for quantifying postural control , and the effects of FRIDs on postural control were abstracted.
Ninety-four patients were included.
Ninety-four percent of residents reported being satisfied or very satisfied with telemedicine care.
Ninety-nine patients received interventions and @number@ received standard care.
Ninety-nine percent of injectors would recommend Voluma to colleagues and patients ( @percent@ ) ; @percent@ of patients would recommend it to friends.
Ninety ( @number@ ) female volunteers , aged 46-67 years , were enrolled.
Ninety-one healthy children aged @number@ to @number@ years and @number@ adults were enrolled.
Ninety-one percent patients were satisfied with the correcting effect.
Ninety percent of adult GBM patients die within @number@ months after diagnosis.
Ninety percent of all prescription NSAIDs are taken by patients over @number@
Ninety percent of Canadians face an increased risk , which could be modified by managing these health behaviours and risk factors.
Ninety percent of the patients were either \ "satisfied \ " or \ "very satisfied \ " with the treatment results.
Ninety-seven CNAs ( @percent@ ) reported actions responding to R-REM incidents involving @number@ residents ( @percent@ ) , describing @number@ different responses.
Ninety-seven Italian centers located throughout Italy were involved.
Ninety-seven of @number@ acatalasemics had diseases related to oxidative stress and aging.
Ninety seven percent of infants were born with RSV-matAb.
Ninety-seven percent of patients were satisfied with the CHWs ' support.
Ninety-seven subjects ( @percent@ ) were in the low protein group , and @number@ ( @percent@ ) were in the higher protein group.
Ninety-seven women completed the trial.
Ninety-six headache centers were selected and contacted via e-mail.
Ninety-six NL individuals with FDG-PET were examined , including @number@ MH , @number@ PH , and @number@ NH.
Ninety-six participants from the Barcelona-AsIA Neuropsychology Study were included.
Ninety-three healthy children , aged 3-12 years , participated in this study.
Ninety-three participants completed feedback questionnaires.
Ninety-three percent ( N = 153 ) of patients who underwent LEMG had weakness in the distribution of at least one nerve.
Ninety-two subjects ( @number@ SVD patients , @number@ AD patients , and @number@ healthy controls ) were assessed using the ACE-R.
Ninety-two virologically suppressed HIV + patients on HAART and @number@ HIV uninfected ( HIV- ) controls underwent neuropsychological performance ( NP ) testing and neuroimaging.
Ninety women and @number@ men developed aMCI during follow-up.
Nine were small research studies and five were quality improvement initiatives.
Nine-years mortality risk was calculated by multivariate Cox proportional hazards model.
Nine years of follow-up data was gathered from the Kungsholmen project , a prospective population-based study on @number@ persons without dementia.
Nine young ( @number@ ± @number@ years ) and eight masters ( @number@ ± @number@ years ) runners participated.
NIRS , ECG and performance data showed a significant interaction between the group and condition.
Nitric oxide level was determined by Griess reaction.
Nitric oxide , matrix metalloproteinase ( MMP ) -3 , and MMP-13 release were measured by Griess reaction and ELISA , respectively.
Nitric oxide may influence skeletal muscle function through effects on excitation-contraction coupling , myofibrillar function , perfusion , and metabolism.
Nitric oxide ( NO ) and tumor necrosis factor α ( TNFα ) production were measured in both in vivo and in vitro studies.
Nitric oxide ( NO ) can mediate redox reactions via S-nitrosylation , representing transfer of an NO group to a critical protein thiol.
Nitric oxide ( NO ) concertation was measured in the medium supernatant.
Nitric oxide ( NO ) -donating NSAIDs , have a safer profile while maintaining anti-inflammatory activity of parent compounds.
Nitric oxide plays a role in the protection against CVD onset and progression but has not been studied around the time of menopause.
Nitrite also acts as an independent signaling molecule , exerting many of the effects previously attributed to NO.
Nitrite has been discovered to be a vasodilator that is preferentially harnessed in hypoxia.
Nitrite-modified ECM increased production of C3a in iPSC-derived RPE cells by @number@ ± @number@ ng / mL ( p < 0.05 ) .
Nitrogen balance ( NB ) response to varying protein intakes was compared between critically ill , older and younger patients.
Nivea Beauty Protect Foundation shade sample was used as a guide to assess facial skin colour Shin colours were also assigned to four ordinal values.
NIV should be offered as an alternative to patients considered poor candidates for intubation and those with a DNI order.
NKAP has an RS motif at the N-terminus followed by a highly basic domain and a DUF @number@ domain at the C-terminal region.
NKCC1 levels and functionality are altered in certain disease states , and tend to decline with age.
NK-cells functionality was determined in response to K-562 , @number@ and @number@.221-AEH cell-lines.
NK cells participate in innate immune surveillance against intracellular pathogens and malignancy but their role in AD remains controversial.
NK cells represent an important component of the innate immune response against infection and tumors.
NK cell subsets are differentially affected by aging.
NKG2D expression was decreased in T cells of elderly subjects.
NKX3.1 degradation is activated by phosphorylation at C-terminal serine residues that mediate ubiquitination and protein turnover.
NL FHm showed reduced GMV in LOAD-affected brain regions compared with FH- and FHp , indicating higher risk for Alzheimer's disease.
NLRP1 and Casp1 siRNAs also abolished stress-induced Casp6 activation in neurons.
NLRP1 immunopositive neurons were increased 25- to 30-fold in AD brains compared with non-AD brains.
NLRP1 immunoreactivity in these neurons co-localized with Casp6 activity.
NLRP1 neutralizing antibodies in a cell-free system , and NLRP1 siRNAs in neurons hampered stress-induced Casp1 activation.
NLRP3 inflammasome was found to mediate IL-1β secretion through the production of ROS ( reactive oxygen species ) during the senescence of endothelial cells.
NLRP3 ( NOD-like receptor family pyrin domain-containing3 ) inflammasome plays a central role in inflammatory response that is associated with diverse inflammatory diseases.
NLS women completed five interviews from @number@ to @number@
NMDA receptors are typically excited by a combination of glutamate and glycine.
NMNAT also catalyzes the metabolic conversion of potent antitumor prodrugs like tiazofurin and benzamide riboside to their active forms which are analogs of NAD.
NMO preferentially exhibited central lesions of the spinal cord with strongly necrotizing features and axonal injury.
NMR and molecular docking demonstrated transient interactions between native S100A9 and Aβ.
NMR , as well as human , was also found to have a lower rate of germline nucleotide substitution than the mouse.
NMR titration and Molecular Dynamics simulation identified the residues within RRM1 and RRM2 responsible for the interaction between DHTS and HuR.
NMS negatively impacts a subject's quality of life and is a growing cost issue in our aging society , as its incidence increases with age.
NMU was reported by @percent@ of participants.
NNT knockdown cells show limited abilities to maintain NAD Estrogen administration following menopause has been shown to support hippocampally mediated cognitive processes.
( N = @number@ n = @number@ male , n = @number@ female ; mean age @number@ ± @number@ ) .
No additional improvement in burnout , depression or anxiety was observed in the aerobic group compared with controls.
No adverse consequences of the PSHG application were observed.
No adverse effects were observed on control cells at optimal concentrations.
No adverse events occurred in either study group.
No adverse events were attributed to PattonProtocol-1.
No adverse events were recorded.
No adverse events were reported.
No adverse events were reported.
No adverse events were reported.
No adverse events were reported.
No adverse events were reported.
No adverse events were reported.
No adverse events were reported.
No adverse events were reported by the women after yoga practice.
No adverse events were reported for all participants across all sessions.
No adverse reactions to therapy were observed.
No adverse reaction was reported.
No age-associated findings were seen in plasma Aβ1-42 or Aβ1-40.
No age-dependent NAA decreases were observed in the PCC nor the HC.
No age differences existed in the symmetry indices.
No age differences in NA responses as a function of stressor severity were observed.
No age differences were observed regarding the alpha-amylase awakening response.
No age difference was found for the effects of CB ( age × CB ) on SMC.
No age effects on the presentation order ( predictable or random ) of the translations were observed.
No ageing effects were obtained for toe trajectory control.
No age or muscle effects were detected for SP measurements.
No age-related decline in sleep duration or quality was observed in Haiti.
No age-related differences in eccentric torque production were detected.
No age-related differences were detected in the expression of DNA damage-signaling genes.
No age related differences were found for either the absolute or relative creep responses ( p ≥ @number@ ) .
No age-related differences were observed in access.
No age-related differences were seen in esophageal body pressures or peristalsis duration.
No age-related increase in behavioral switching costs was observed.
No alteration in the technique of anesthetic induction or maintenance was required for the study.
No alternative scoring system was better than standard scoring of word-list recall in distinguishing MCI patients from controls.
No alternatives exist for patients who do not respond to combination therapy.
No anatomical differences were observed in the facial skeleton.
No aneurysm-related death was observed during follow-up.
No ankle or knee kinematic adjustment was found at foot strike in used shoes but changes were observed later during stance.
No apparent association was found with ROA.
No areas were found to be more active during the ankle DF / PF task when compared with the active balance simulation task.
No articles meeting inclusion criteria were identified to evaluate osteoporosis risk in this group.
No association between ApoE and delirium severity or number of delirium days was observed.
No association between baseline TSH and risk of developing any MCI subtype or AD was found.
No association between cCSA / tCSA and atherosclerosis was observed in men.
No association between education and disability on the individual ADL , IADL , and mobility was observed.
No association between ferritin levels and cardiovascular mortality was detected in women.
No association between MedDiet scores and change in Modified Mini Mental State Examination score was seen among white participants ( p = @number@ ) .
No association between SAF and hypovitaminosis D was revealed.
No association between smoking and cortical cataract was observed.
No association between smoking and menopause was identified in CYP1B1 wild types.
No association between tea intake and CRP level was observed.
No association for episodic memory impairment was found.
No association is demonstrated between the HFE p.C282Y nor the AGTR1 c.1166A → C polymorphisms and WML severity.
No association of PD with in-hospital death was noted.
No association of SG-BPA with FSH or OV was observed.
No associations between breast-feeding duration and exclusivity with growth rates before the age of @number@ months were observed.
No associations between maternal PHIV status and preterm delivery , SGA , or LBW were observed.
No associations between TSH and DXA or pQCT measurements were found.
No associations of mild-to-moderate CAA with cognition were found.
No associations replicated externally ( N = @number@ ) .
No association studies have yet been reported supporting any candidate gene.
No associations were detected with ESR1.
No associations were found between coping resources and home nursing care.
No associations were found between employment status and MC.
No associations were found between lactase nonpersistence and BMD changes.
No associations were found between social support and prostate cancer screening.
No associations were found for goal reengagement capacities.
No associations were found for maternal education , asset ownership , or sanitation and hygiene factors.
No associations were found with evening cortisol.
No associations were identified with blood lead.
No associations were observed between hsCRP and childhood poor health or childhood economic adversity.
No associations were observed in CMV ( - ) individuals.
No associations were observed in men.
No associations were seen in the remaining three domains.
No associations were seen in women who had natural menopause.
No associations were seen with the CRAE , or between zBMI or zWC and the retinal microvasculature.
No associations with morphological LAA features could be found for patients with diabetes , hypertension , or dyslipidemia.
No association to AD was found.
No association was found between DTI parameters and gestational age , degree of WM injury or categorical clinical factors.
No association was found between height-adjusted BMD Z score and T-cell activation or senescence.
No association was found between MDBI and the outcomes evaluated.
No association was found between Mg and grip strength.
No association was found between patient characteristics and patient quality score.
No association was found between plasma hormones levels and atherosclerotic plaques.
No association was found between p.R47H and FTD-S.
No association was found between RBCLS and any of the inflammatory biomarkers.
No association was found between respiratory diseases or cancer mortality and global MMSE score.
No association was found between retinal sublayer thickness and white-matter lesion volumes , cerebral microbleeds , or lacunar infarcts.
No association was found between retinol , total non-pro-vitamin A carotenoids , lutein , zeaxanthin , and lycopene , and E2 levels.
No association was found between these states and the presence of other vascular risk factors , or more severe stroke or worse outcomes.
No association was found between visual impairment and socioeconomic status of subjects.
No association was found for an interaction between plasma Aβ42 levels and GDS.
No association was found for aspartate transaminase.
No association was found for declarative memory.
No association was found for patient's medical or geriatric status.
No association was found in AD.
No association was found in the opposite direction.
No association was found with cardiovascular disease.
No association was found with finger tapping and grip strength.
No association was found with incident depression.
No association was initially present between diurnal measurements of testosterone or morning basal testosterone levels and buccal TL.
No association was observed between degenerative manifestations and variation in the other genes.
No association was observed between increased intermuscular adipose tissue and hypertension.
No association was observed for memory and reasoning.
No association was observed for other comorbidities such as chronic pulmonary obstructive disease ( COPD ) or heart conditions in the adjusted model.
No association was observed for pork ( RR = @number@ @percent@ CI = @number@ to @number@ ) , but some between study heterogeneity was observed.
No association was observed for poultry consumption and risk of colorectal adenomas or cancer.
No association was observed for TNF-α.
No association was observed for urine cadmium levels with walking speed.
No association was observed with other criteria.
No association was reported between the single nucleotide polymorphisms ( SNPs ) of IGF-1 and longevity in the only available study.
No association was seen between psychological measures and ABI.
No association was seen between sarcopenic obesity groups and CHD or CVD events.
No association with either cognitive factor was found among better educated participants.
No association with LINE-1 methylation was identified.
No association with sex of patient , diabetes or arterial hypertension was found.
No asymmetric differences were observed between each breast , except for nipple-inframammary fold length in 20-30-year-old women and upper arm length in 41-50-year-old women.
No asymmetry was observed in the resting state.
No atorvastatin-related side effects were documented.
No author has a financial or proprietary interest in any material or method mentioned.
No autopsy confirmed study of @number@ years and older onset in parkinsonism cases has been reported.
No balance parameter discriminated between three frailty levels.
No beneficial aging effect was observed-instead , the strength of all four model GPC formulations was found to degrade with time.
No beneficial cardiovascular effects of escitalopram were observed in those under the age of @number@
No beneficial effects of levothyroxine were seen on secondary-outcome measures.
No beneficial effects of the surviving parent's remarriage were detected.
No beneficial effects on the Fugl-Meyer Assessment and other sensorimotor outcomes were found for the MT + MG group.
No benzodiazepine category was associated with day-time drowsiness.
No binding effects of apomorphine were observed.
No case of irregular contour , palpable lumpiness , or unevenness were encountered.
No cases of cerebellar neurotoxicity occurred.
No cases of CRC were reported.
No cases of serious adverse events were attributed to the study's drug therapy.
No cases were converted to transurethral resection of the prostate intraoperatively due to bleeding ( P = 0.142 ) .
No CHADS ( @number@ ) covariate had a high strength of evidence for association with any bleeding type.
No change in CDVA was found with the monofocal IOL.
No change in DS over time was observed ( slope = @number@ p = @number@ intercept = @number@ p < @number@ ) .
No changes in body weight , BMI or body fat percentage occurred as a result of the intervention in either group.
No changes in downstream TGF-β signaling and increased platelet turnover suggest that chronic vascular damage may partially explain increased plasma TGF-β1.
No changes in EKG-corrected QT interval were observed , and no serious adverse events were reported.
No changes in EMG or MVC were observed across blocks for either group.
No changes in stool fat or total or soluble stool nitrogen were observed in the minority of patients for whom stool analysis was performed.
No changes in vascular stiffness were observed.
No changes were found in BMD either due to small sample size , short duration of study or no effect.
No changes were found in the hemispheric and lobar distribution of hyperintensities.
No changes were observed for V˙O2max expressed relative to lean body mass or leg lean mass.
No changes were observed in cognitive status and bowel function.
No changes were observed in old animals.
No changes were observed on the control side.
No changes were reported in speed of movement.
No changes were seen in the remaining outcomes.
No change was detected in the serum levels of thyroid hormone ( T3 or T4 ) in a subsample of HS cases prior to death.
No change was found for lipid and glucose levels.
No chemosis , prolonged swelling , lower eyelid retraction , or ectropion was seen in any patients.
No children had ideal levels for either zero or all @number@ metrics.
No clear associations were identified between general SS , SSPA from friends , or loneliness and PA levels.
No clear association was found between ADHD subtypes and changes of brain metabolites with use of MPH in adult ADHD.
No clear distinction on the injury pattern was observed by age group.
No clear optimal level of TC was identified.
No clear trends associating the number of units in a facility with resident characteristics were observed.
No clinical feature was associated with institutional outpatient care.
No clinically apparent immunodeficiency was observed , suggesting age-related EBV-associated lymphoproliferative disorder caused by an underlying age-related reduction in immunocompetence.
No clinical predictors of disease onset were demonstrated.
No clinic recommended that travellers consult a travel medicine specialist or receive vaccinations prior to their intended travel.
No CML was detected in clarified butter , and no HMF was detected in raw and clarified butters.
No color alteration was observed with cardol and cardanol treatments.
No competing interests.
No complication related to sensory abnormalities and visible scars was observed.
No complications occurred , though fat grafts resorbed in one patient.
No complications such as bleeding , intestinal perforation , etc. , were observed.
No complications such as hematomas or infection were seen on postoperative follow-up.
No complications were experienced with either device.
No component of neuroticism was related to the neuropathologic lesions most commonly associated with late-life dementia.
No component of the AHA-DLR alone was responsible for the observed positive associations.
No confirmed genetic susceptibility factors have been identified using candidate gene approaches.
No consensus exists about the accurate prevalence rates of frailty.
No consensus has been reached on how musculoskeletal system injuries or aging can be explained by a walking plantar impulse.
No consistent age related patterns were found for the ratios and the nasal convexity and alar slope angles.
No consistent association between lower limb asymmetry and measures of physical functioning was observed.
No consistent associations were seen in cause-specific mortality analyses.
No consistent correlation was found between trophic factor mRNA expression and protein secretion.
No consistent differences were observed between cohorts.
No consistent interactions with sex , race , or hypertensive status were observed for any outcome.
No consistent longitudinal loss in lung function was observed with RCF exposure.
No convincing evidence shows that pharmacological prevention or treatment is effective.
No correlation between plasma cytokines or chemokine levels and cognitive scores was found.
No correlation between μTBS and dentin hardness was observed.
No correlation of corneal thickness with age or of BL thickness with corneal thickness was observed.
No correlation of SORL1-mRNAs expression was found between frontal and temporal cortexes.
No correlations between DC and optical properties were observed.
No correlations were found between leptin and the inflammation markers.
No correlations were found in patients without dementia.
No correlations were observed between higher BMI increases and cortical volumes.
No correlations were observed with lutein and zeaxanthin in the hippocampus.
No correlation was detected between the lowback pain disability index and neuromechanical variables.
No correlation was found between age and SITT ( Pearson correlation coefficient @number@ ) .
No correlation was found between any brain measurement and CSF Aβ ( @number@ ) level.
No correlation was found between any recognition variables and perirhinal or entorhinal cortices volumes.
No correlation was found between blood neutrophils and age.
No correlation was found between circulating IL-8 and the migratory capacity of neutrophils.
No correlation was found between physical function and degree of immunosuppression as determined by pre-ART CD4 nadir.
No correlation was found comparing GH peak after ITT with the same parameters.
No correlation was observed between age and elasticity of the lower labial mucosa.
No correlation was shown between these changes in electrolytes and muscle strength.
No correlation with aging was found for lumbosacral parameters or sagittal balance ( P > @number@ ) .
No correlation with PMA-at-scan was observed in the CC or SLF , regions that myelinate later in infancy.
No cortical regions showed more surface area reduction than the global average.
Nocturia and its ethiology can be determined in most cases with simple and commonly used investigative methods on the out-patients bases.
Nocturia and related parameters of poor quality can be explained by impaired bladder neck perfusion.
Nocturia episodes , co morbid illnesses , beverage intake frequency , medications and work history were documented.
Nocturia has a negative impact on quality of life , affecting both morbidity and mortality.
Nocturia is a cardinal symptom of LUT dysfunction and is more prevalent with aging.
Nocturia is a common complaint in elderly population.
Nocturia is a variable symptom and its presence in individuals is reversible therefore it is very difficult to obtain reliable incidence data.
Nocturia is one of the most common reasons for interrupted sleep in general adult population.
Nocturia prevalence varies remarkably in different studies according to evaluation methodology , nocturia definition , methods of data collection and characteristics of evaluated population.
Nocturnal blue light exposure is currently increasing , due to the proliferation of energy-efficient lighting ( LEDs ) and electronic devices.
Nocturnal GH secretion was increased , and evening and nocturnal TSH levels were decreased under progesterone ( P ≤ @number@ ) .
Nocturnal hypoglycaemia included confirmed episodes from @number@ to @number@ hours ( inclusive ) .
Nocturnal polysomnography.
Nocturnal SBP and PP correlated more strongly with cardiac organ damage ( p < 0.001 ) .
No current age- and gender-related normative data exist for the dimensions of facial structures in Northern Sudanese subjects.
No current analytical methods can simultaneously determine AAR and AAI during the degradation of Aβ from AD patients.
NODDI , DKI , and MET2 indicate that the initial decrease in frontal fractional anisotropy may be due to increased axonal dispersion rather than demyelination.
NODDI metrics indicate fractional anisotropy changes are underpinned by combinations of axonal loss and morphological change.
No deaths were observed among the patients with neither shock nor PI in the ED.
No definite conclusions can be inferred in relation to EL owing to its lack of association with both rs1815739 and rs1805086.
No definite guideline for their use can thus be proposed at the moment.
No degradation of the resin-dentin bond strengths was observed for specimens stored in MO ( p > 0.05 ) .
No delamination wear was observed in remelted HXLPE in agreement with its comparatively low oxidation levels ( oxidation index < @number@ ) .
No deletions or duplications involving FBXO7 exons were identified.
No dementia was detected on neurological examinations.
No detectable FSH receptor mRNA in mouse bone or cultured osteoblasts or osteoclasts indicated that FSH did not directly stimulate bone.
No device-related serious adverse events occurred during the study.
No diabetic ketoacidosis episodes were observed during the follow-up , and severe hypoglycemia significantly decreased in SAP patients ( P = @number@ ) .
No difference between contraction types on EMG values was observed.
No difference in accuracy was observed for samples obtained either from living and deceased individuals or between the @number@ genders.
No difference in attentional demand as a function of stimulus was observed.
No difference in load distribution was found between the two groups.
No difference in mGluR2 / 3 density was identified in relation to schizophrenia diagnosis.
No difference in mortality was noted between eEVAR and OPEN over @number@ years of follow-up.
No difference in obesity measures ( p = 0.92 ) and adiponectin levels ( p = 0.27 ) was observed between African and Caucasian women.
No difference in the association between APOE allele and mortality was observed between AAs and EAs.
No difference in the baseline biomarkers between both groups was found.
No difference in TL between controls and patients was shown at baseline , nor any significant difference in TL stability or attrition during follow up.
No difference in vestibular ganglion cells was noted based on sex.
No difference occurred in monitoring accuracy for young versus older adults.
No difference of resting MSNA was observed between ozone and air exposure ( air : 23±2 , ozone : 23±2 bursts / min ) .
No differences among groups were observed during recovery.
No differences between changes in TG and RG were found over the intervention period , neither in physical function tests nor psychological questionnaires.
No differences between CSF α-synuclein concentrations of patients with PD with the reference values from our laboratory were observed.
No differences between groups were found for the other cognitive tests assessed.
No differences between the two subtypes were found on perceived health or depression.
No differences could be outlined about multiple sclerosis clinical form of the disease.
No differences existed for variables during intermittent weeks.
No differences for any other cognitive or composite measures were observed.
No differences in any of the tested markers were found in serum and urine between baseline and post-exercise.
No differences in cortical and subcortical gray matter and white matter MTI parameters were found between offspring and control subjects using histogram-based and voxel-wise analyses.
No differences in GST activity were detected among the groups.
No differences in heart rate reactivity between three groups were found.
No differences in increase of activity were found between the two groups.
No differences in matching accuracy were found between young and older participants when matching ipsilaterally.
No differences in mortality were found for patients with dementia , without dementia or other neurological disorders.
No differences in motion sensitivity were found in the older groups aged under or over @number@ years.
No differences in outcome were found for patients treated with versus without darbepoetin alfa.
No differences in pain intensity were observed among age subgroups.
No differences in polypharmacy were found between sex and fully dependent versus mobile demented residents.
No differences in postural sway or RT emerged between the BMT and BMT + C groups.
No differences in regional gray matter volume were found , except for a small cluster of higher volume in the precentral gyrus in carriers.
No differences in required friction were found between non-obese and obese younger adults.
No differences in substantia nigra pigmented neuron loss scores were found.
No differences in the effects of self-efficacy were found for distress levels of caregivers who dealt with low frequency of BPSD.
No differences in the simple discrete condition were shown compared to single-task standing , perhaps due to the simplicity of the task.
No differences were found at age @number@
No differences were found between groups for NKA content , abundance of other NKA isoforms , or gene expression.
No differences were found between groups for the @number@ ms-85 dB and @number@ ms-85 dB.
No differences were found between groups in any acoustic variables on samples recorded with habitual intensity level.
No differences were found between groups in internal sphincter pressure , voluntary contraction or during balloon distension.
No differences were found between groups ; laboratory tests showed no significant alterations.
No differences were found between rest-activity pattern and frailty phenotype.
No differences were found between the sexes.
No differences were found between the two groups of patients with known rotator cuff disease.
No differences were found for the interpersonal interactions and relationships domain.
No differences were found for the other markers.
No differences were found in adverse events or numbers of falls.
No differences were found in androgens between BPH and PCa.
No differences were found in cell viability between the control and treated groups at any time.
No differences were found in non-dialysed CKD patients.
No differences were found on the cognitive control or fluency scores.
No differences were found regarding bimanual performance or hand dominance.
No differences were found regarding other PACU incidents , length of PACU stay or hospital stay.
No differences were found when comparing frozen embryo transfers.
No differences were noted between 3D TOF-MRA and CE-MRA concerning the detection and location of the @number@ aneurysms or visualization of the parental artery.
No differences were noted in the other parameter evaluated.
No differences were observed across older adult groups based on mTBI status.
No differences were observed between FHp and FH- in any regions.
No differences were observed for gender.
No differences were observed in any of the gait or working memory dependent variables as a function of task condition.
No differences were observed in overall and severe hypoglycemia.
No differences were observed in post-operative complications.
No differences were observed in protein catabolism.
No differences were seen in Q CONCLUSION : Two weeks of statin ( S or P ) treatment have no major effect on mitochondrial function.
No differences were seen in these effects between detemir and glargine.
No difference was found between healthy elderly and patients with coronary artery disease.
No difference was found between PTH groups in flow- or nitrate-mediated brachial artery dilatation , coronary artery calcification , intima-media thickness , or arterial stiffness.
No difference was found in mortality , length of ICU stay , mechanical ventilation duration , postoperative infection and major organ dysfunction.
No difference was found in negative emotions and suppression between younger and older adults.
No difference was found in response amplitude and latency between the inferior and superior retina.
No difference was observed between groups.
No difference was observed for LAT1 / LAT2 mRNA levels.
No difference was observed in ROS production for both cells after TNF-a exposure.
No differential ageing effect was observed.
NO diffuses into neighboring cells , thus acts in both SCF- and KIT-expressing cells.
No disease is experienced in isolation and dementia embodies this.
No disease-modifying therapies are currently available for Alzheimer's disease ( AD ) , a neurodegenerative disorder that affects more than @number@ million people worldwide.
No displacements of the palpebral rim or injuries to the facial nerve were observed.
No dose-response relationship was found between amount of smoking and cortical thickness in these regions.
No dramatic differences in lifestyle risk factors between @number@ BMI groups ( lean , overweight , obese ) were found out.
No effect of age on condylar activity was demonstrated.
No effect of age on normal condylar activity was demonstrated.
No effect of age on the total intensity was found.
No effect of aging on either midbrain / pons or MRPI values was shown in the patients with PSP.
No effect of DAT availability on P300 latency or amplitude was detected.
No effect of gender and smoking was observed.
No effect of rest was detected in the route memory or cognitive map tests , most likely due to ceiling and floor effects , respectively.
No effect on cancer cells was observed using fibroblasts from mouse , rat or Acomys.
No effect on the proliferation of senescent fibroblasts was observed , as expected.
No effects are found on depression and cognitive capacity.
No effects of cardiac output or cardiac index on CBF or structural signs of brain ageing were observed.
No effects of PvuII SNP on ESR1 gene were observed on patient´s serum T-chol , TL , LDL , HDL , and TG.
No effects of surgery on cognition were observed at either age.
No effects were observed in physical activity , frequency of social relationships , and subjective health.
No effect was found on number of hospital admissions , nursing home admissions and on mortality.
No elderly patients treated with total parathyroidectomy were autotransplanted.
No emotion recognition deficits were found.
No endurance differences between age groups were found during the control and cognitive fatigue condition.
No epidermal burns , sensory changes , and muscle contractions were observed.
No evidence for age differences in these patterns was found.
No evidence for association was found between rs976683 and BP variability in the additional ( Scandinavian ) ASCOT participants ( P = 0.18 ) .
No evidence for deficits in neuropsychological performance was found in the aging group of displaced people with PTSD.
No evidence of any gender difference was observed.
No evidence of a WW2 effect was found.
No evidence of publication bias was found based on Begg's and Egger's test.
No evidence was found for depression predicting OE.
No evidence was found for predictive effects of health for changes in perceived control in either age group.
No evidence was found for QoL predicting FOF.
No evidence was found that coffee consumption was harmful to periodontal health.
No evidence was found that stronger social relations reduce the association between depressive symptoms and incident T2DM.
No evident circadian rhythm was present.
No exclusion criteria , other than the reported presence of a congenital color defect , were applied.
No exercise training studies were found involving children.
No extinction was found beyond @number@ days after the first examination.
No false positive results were noted using IHC to detect the BRAF ( V600E ) mutation.
No far transfer effects were seen for either age group.
No findings reached genome-wide significance.
No firm conclusion can be made for safety.
No fractional anisotropy or mean diffusivity differences were observed between non-amnestic mild cognitive impairment patients and cognitively normal subjects.
No frailty marker predicted hospitalization or visits to the GP.
No further relevant mutations were found by direct sequencing of the genes for APOA5 , APOC2 , LMF1 and GPIHBP1.
No gender-associated difference was noticed.
No gender difference in PWV increase with age was observed ( p = @number@ ) .
No gender differences were found.
No gender or age-of-donor biases were observed , and results were linear up to @number@ days.
No generally accepted theory has been proposed to explain these observations.
No gene × social environment interactions were found for loneliness between rs242938 and an adverse social environment related to children.
No genetic effect on total-SORL1-mRNA levels was detected in the frontal cortex.
No genome-wide association study ( GWAS ) has examined the genetic factors affecting allopurinol effectiveness.
No genome-wide significant interaction with smoking status , alcohol consumption or BMI was observed in the meta-analyses.
No genotoxic effect was observed in experiments with FPP exposed to HepG2 cells nor was FPP toxic to the PC12 cells.
No geriatric characteristic was found to be associated with anticoagulation underuse.
No GP enhancement with an increasing number of local elements was observed.
No group differences emerged in subjective sleep or magnetic resonance imaging outcomes.
No group differences in metabolites were observed.
No group differences were found for time-compressed speech , ATTR across-channel , or audiometric measures.
No group differences were identified for ratings of either socially appropriate behavior or stereotyping and prejudice.
No group differences were observed in the recognition of happiness , surprise , disgust , and sadness.
No Group effect was found in older participants , F ( @number@ @number@ ) = 0.82 , p = 0.37.
No guidelines for the management of high blood pressure ( BP ) in centenarians are available.
No harmful treatment side effects occurred.
NO has been found to induce cognitive behaviour in experimental animals.
No heterogeneity emerged across strata of sex , age , education , smoking habits and body mass index.
No histopathology changes were observed in mice administered @number@ g / kg or less.
No ileoduodenal anastomotic stenosis was encountered.
No imaging data is yet available in healthy aged subjects.
No impact of gender , place of residence , education , material situation and disease duration was revealed.
No important associations were observed for miR-125a-5p , -125b , @number@ @number@ @number@ and @number@
No improvements were reported in increasing food intake during child illness or pregnancy.
No increased functional connectivity was found in this cohort.
No increased risk of any type of late development , and cognitive impairment was associated with rs6439886 or rs17070145.
No increased risk was observed for non-smoking-related cancers.
No increase in fecal calprotectin and β-defensin concentrations suggests that the probiotic treatment did not affect intestinal inflammatory markers.
No independent associations between leptin concentrations and cardiovascular risk were present in all patients and either women and men or black and white patients.
No independent associations between MRI measures and memory decline were found.
No independent predictors of B. pertussis infection could be determined for patients older than six months.
No indication for heterogeneity and publication bias was found.
No indirect effect mediated through BMI was observed ( OR 0·99 ; @number@ % CI 0·91 , 1·07 ) .
No infection , hematoma , chronic pain , mesh dislocation or recurrence have been reported to date.
No influence of duration in procedural outcome was observed.
No influence of group on global CBF was observed.
No influence of manipulations was found in young adults.
No influence of the allele status of either SNPs was observed on any memory test.
No interaction between treatment and exercise was observed ( p = @number@ ) .
No interactions between ethnicity and biomedical or psychosocial factors were found.
No interactions were recognized between pet ownership and subjective general health status , loneliness , or marital status.
No interaction was detected between β-carotene or vitamin C and genetic risk status.
No interaction was found between SBP and ATS ( p for interaction > @number@ ) .
No interaction was found with GWAS tag SNPs at or near the MAPT , SNCA , LRRK2 , and HLA loci.
No interaction was noted between the three exposures in affecting depressive symptoms.
No interaction was observed between side and insole ( P > 0.190 ) , even though symmetry was higher with high-density insoles.
No interaction with age was found indicating that the rate of change across ages was similar for bilinguals and monolinguals.
No interpersonal or environmental correlates were significantly associated with blood pressure category.
No intervention studies were identified.
Noise affects VT variability , although its effect on bias was small ( @percent@ ) .
Noise and solvent exposure were assessed using occupational work codes and a job exposure matrix.
NO is known to modulate neurogenesis and neuronal survival in various brain regions in disparate neurodegenerative conditions.
No items in the revised MAL and LF-MAL exhibited bias related to patients ' characteristics.
No language or date restrictions were applied to the electronic searches.
No language restrictions were applied.
No language restrictions were applied.
No laparotomy conversion was required in either group.
No large , longitudinal studies performed in the general population have been conducted to confirm this observation.
No large scale U.S. studies have investigated the association between food insecurity and severity of HIV disease or the mechanism of this possible association.
No lateralised clusters were present for either long or short lines in older adults.
NO LEVEL ASSIGNED : This journal requires that authors assign a level of evidence to each article.
No light-elicited necrosis was measured as compared to control cells maintained in darkness.
No literature overview solely focuses on the physiotherapeutic options in patients with adhesive capsulitis and their scientific evidence.
No long-term exercise training regimen with high adherence and effectiveness for middle-aged and older individuals is currently broadly available in the field.
No long-term exercise training regimen with high adherence and effectiveness in middle-aged and older people is broadly available in the field.
No long-term or other serious complications were observed.
No long-term side effects were noted.
No main effect emerged for language.
No main effect of arsenic exposure on myelomeningocele risk was identified.
No main or interactive effects for Depression were observed.
No major adverse cardiovascular events occurred in either group.
No major complications were noted.
No major complications were reported , including hematoma and dyspigmentation , even in combined cases with surface lasers.
No major effect modification was exerted by smoking status or cancer histology.
No meaningful interaction of age and bipolar disorder has been found in terms of cognitive decline.
No measure clearly distinguished the control and cognitive impairment groups.
No measures were taken in the comparison group ; pain management continued as before , but after the study corresponding training was provided.
No medication class was associated with either outcome.
No meta-analyses could be conducted for other outcome measures , because too few studies were available.
No meta-analyses on this topic have yet been published.
No meta-analyses were conducted because of substantial heterogeneity among the included studies.
No moderation effects were found for Neuroticism.
No modifications particular to the aneurysms were dissociated from those observed in atherosclerosis.
No mortality was reported in our patients , however , one-year adverse outcomes were encountered in @number@ ( @percent@ ) patients.
No mutation of KRAS , BRAF , and EGFR genes at the investigated loci was found.
No mutations in CHCHD2 were found in our @number@ PD patients.
No mutations or copy number variants predicted to be pathogenic were identified.
No mutations were identified , indicating that MATR3 mutations are not a common cause of ALS in Australian familial cases with predominately European ancestry.
No mutation was detected in both smokers and nonsmokers in p53 codon @number@
Non-ablative lasers are safer but have limited efficacy.
Nonablative techniques minimize side effects and patient downtime ; however , they do not match the results seen in fully ablative procedures.
Non-adherence was measured by a pill-count.
Nonadherence was measured using Medication Possession Ratio < 0.8.
Non-AD neurodegenerative pathologies and their combinations have been underestimated , but are frequent in reality as demonstrated here.
Nonagenarians are the oldest members of our societies and survivors of their generation.
Nonagenarians scoring up to @number@ points on the BI were defined as individuals with significant functional impairment.
Nonagenarians with cognitive decline were defined as those individuals with a score of @number@ or less on the MEC.
Non-AIDS comorbidities are increasing , and the spectrum of HIV-related thoracic diseases is evolving.
Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed countries.
Non-alcoholic fatty liver disease ( NAFLD ) is also an oxidative stress-related disease.
Non-apathetic , depressed patients showed a failure to adopt a conservative strategy and persisted in making risky decisions throughout the task.
Non-carriers of the allele showed this asymmetry only in the patient group.
Non-cell-autonomous DNA damage responses activate the innate immune system in multiple metazoan species.
Non-classical theories , in contrast , posit that an increase in extrinsic mortality could select for the evolution of longer lifespans.
Nonclinical juvenile toxicity studies are usually required as part of this assessment.
Non-clinically significant dose-dependent reductions in haemoglobin concentrations were the most common laboratory abnormality.
Non-coding DNA variants are suspected to account for a substantial part of undiscovered causes of rare diseases.
Noncoding nucleotide repeat expansions in several genes are also associated with neurodegenerative and neuromuscular diseases.
Non-coding RNAs ( ncRNAs ) and their associated regulatory networks are increasingly being implicated in mediating a complex repertoire of neurobiological functions.
Noncoding RNAs provide epigenetic regulatory circuits within the kidney , which reciprocally interact with DNA methylation processes , histone modification and chromatin.
Noncommunicable diseases are rapidly overtaking infectious , perinatal , nutritional , and maternal diseases as the major causes of worldwide death and disability.
Noncommunicable diseases have been established as a clear threat , not only to human health but also to the development and economic growth.
Non-communicable diseases ( NCDs ) are a leading cause of death and disability , representing @percent@ of the total death number worldwide.
Noncommunicable diseases ( NCDs ) contribute to a significant amount of disability and death in the world.
Noncommunicable diseases ( NCDs ) have become the major contributors to death and disability worldwide.
Non-comparative studies were assessed for quality with use of the Effective Public Health Practice Project ( EPHPP ) Quality Assessment Instrument.
Noncompartmental approaches give limited physiological insight in the compartmental characteristics.
Non-conditional logistic regression model was used for odd ratio ( OR ) and 95%CI calculation , with statistic analysis through SPSS @number@
Non-contact tonometry was performed ( CT-80 , Topcon Inc. , Japan ) .
Noncorrectable visual impairment was found in @percent@ of subjects , including @percent@ of subjects with unilateral and @percent@ of subjects with bilateral visual impairment.
Noncycloplegic refraction was measured semiannually for @number@ years and annually thereafter.
Nondemented adults with diabetes exhibit neuroanatomic and cognitive abnormalities.
Non-demented elderly also showed considerable synaptic tau hyperphosphorylation and some misfolding , implicating the synapse as one of the first subcellular compartments affected by tauopathy.
Nondemented patients underwent a comprehensive neuropsychological evaluation and participated in our Wisconsin Card Sorting task functional magnetic resonance imaging protocol.
Non-dental tissues for age estimation may be suitable for age estimation based on AAR if they contain durable proteins that can be purified and analysed.
None
None
None : A country-specific FRAX model has been developed for the Ukraine to replace the Austrian model hitherto used.
None : Aging is accompanied by profound changes in the brain's dopamine system that affect cognitive function.
None : Application of collagen cross-linkers to demineralized dentin improves bond durability.
None : Background / Study Context : Interest in frailty is growing in low- and middle-income countries , due to demographic aging and resource limitations.
None : Background / Study Context : Reduced processing speed pervades a great many aspects of human aging and cognition.
None : Background / Study Context : Reports of age-related differences on motion discrimination tasks have produced inconsistent findings concerning the influence of sex.
None : BPC @number@ a pentadecapeptide with extensive healing effects , has recently been suggested to contribute to angiogenesis.
None : Cancer and its treatment are frequently associated with cancer-related cognitive impairment ( CRCI ) .
None : Cancer cells display altered glucose metabolism characterized by a preference for aerobic glycolysis.
None : Chronic obstructive pulmonary disease and lung cancer are leading causes of death with comparable symptoms at the end of life.
None : During the first months of life , human infants process phonemic elements from all languages similarly.
None : Growing evidence suggests that regular moderate-intensity physical activity is associated with an attenuation of leukocyte telomere length ( LTL ) shortening.
None : Growth hormone is the major regulator of growth and body composition.
None : Hepatic fibrosis is a global health problem currently without effective therapeutic approaches.
None : Hepatocellular carcinoma ( HCC ) is the leading cause of death in patients with cirrhosis.
None : How does the robust control of walking and balance break down during a fall ?
None : Hydrocephalus is a brain disorder derived from CSF accumulation due to defects in CSF clearance.
None : It has been hypothesized that high protein intakes are associated with lower bone mineral content ( BMC ) .
None : It has been proposed that protein supplementation during resistance exercise training enhances muscle hypertrophy.
None : Lineage development is a stepwise process , governed by stage-specific regulatory factors and associated markers.
None : Liver fibrosis is common , particularly in individuals who are infected with human immunodeficiency virus ( HIV ) .
None : Local heating of an extremity increases blood flow and vascular shear stress throughout the arterial tree.
None : Low bone mineral density ( BMD ) and osteoporosis have become a public health problem.
Non-English language studies were filtered out at search stage.
None : Nonsteroidal anti-inflammatory drugs ( NSAIDs ) are used as pain killers during periods of unloading caused by traumatic occurrences or diseases.
Nonenzymatic crosslinks form as a result of reactions which create advanced glycation end products ( AGEs ) , such as pentosidine and glucosepane.
Non-enzymatic damage to nuclear proteins has potentially severe consequences for the maintenance of genomic integrity [ @number@ ] .
Non-enzymatic glycation and cross-linking of protein alter its structural integrity and function , contributing to the aging of macromolecules.
Non-enzymatic lipophilic antioxidants may play a pivotal role in our aging process , and are reflected in our dietary lifestyle and dietary supplementation.
Nonenzymatic post-translational modification ( PTM ) of proteins is a fundamental molecular process of aging.
Non-enzymatic protein glycosylation ( glycation ) contributes to many diseases and aging of organisms.
None : OBJECTIVES : We aimed to determine the feasibility and safety of applying ERAS pathways to emergency elderly surgical patients.
None : Obtaining vascular smooth muscle tissue with mature , functional elastic fibers is a key obstacle in tissue-engineered blood vessels.
None : Orthopedic hardware impairs image quality in cross-sectional imaging.
None : Osteoarthritis is the most common joint disease.
None : POPULATION : ( D OBJECTIVES : Myofibromas are uncommon soft tissue tumors exhibiting considerable histopathologic overlap with other benign and malignant entities.
None : Psychological challenges , including traumatic events , have been hypothesized to increase the age-related pace of biological aging.
None : Schizophrenia is a debilitating psychiatric disorder manifested in early adulthood.
None : Soft tissue filler injections are the second most common non-surgical procedure performed by the plastic surgeon.
None : Studies have investigated the potential protective effects that diet may have on late-life depression incidence.
None : Studies suggest that both pre- and postnatal factors are predictors of age of attaining milestones in infancy.
None : Tendons transmit muscle-generated force through an extracellular matrix of aligned collagen fibrils.
None : The ability to navigate through space involves complex interactions between multiple brain systems.
None : The aim of this study is to determine changes in sedentary behaviour in response to extensive aerobic exercise training.
None : The detection of changes in lean mass ( LM ) distribution can help to prevent disability.
None : The development of pain is common in midlife , resulting in increased health care utilization and costs.
None : The elderly population is increasing worldwide , associated with an increase in diseases related to aging , such as hip fractures.
Nonetheless , adult offspring of Holocaust survivors showed no differences in their physical , psychological , and cognitive functioning as compared to matched controls.
Nonetheless , aerobic glycolysis remains a prevalent metabolic pathway in the brain.
Nonetheless , a linear relationship between increasing adiposity and skeletal development seems unlikely.
Nonetheless , almost @percent@ of residents recommended ablation to manage SRMs in the aging , comorbid patient.
Nonetheless , a prolonged residence time for LDL apoB of 2-5 days , made LDL more atherogenic.
Nonetheless , at present , no definitive dietary recommendations are possible.
Nonetheless , circulating sclerostin levels in humans often reflect changes in the bone microenvironment , although there may be exceptions to this observation.
Nonetheless , correlates of suboptimal vitamin D levels in young adults are not well defined.
Nonetheless , despite high serum adiponectin and low inflammation , approximately @percent@ of CR individuals exhibited an exaggerated hyperglycemic response to a glucose load.
Nonetheless , early surgery necessitates a shorter time for preoperative medical preparation , in particular cardiac assessment.
Nonetheless , epidemiological evidence in this regard is not conclusive so further research is warranted.
Nonetheless , fears that an aged population leads to economic stagnation and public bankruptcy are widespread.
Nonetheless , further efforts are needed to encourage Canadians to voice their health care and research preferences in the event of incapacity.
Nonetheless , further epidemiological studies are necessary to confirm our results and to gain additional insights into underlying mechanisms.
Nonetheless , further standardization of disability measurement is required before disability could replace TTD in LTCE projections models.
Nonetheless , GBS remains a leading cause of neonatal sepsis , including @number@ late-onset ( LOGBS ) cases annually.
Nonetheless , genetic and epigenetic studies of neotenic subject's DNA are on-going.
Nonetheless , little is known about the association between DSD and clinical outcomes.
Nonetheless little is known about the WM alterations that may underlie different cognitive status in older individuals.
Nonetheless , more work needs to be done in order to verify the reliability of these findings on a large sample.
Nonetheless , most of the efforts evaluating immune status in critically ill patients have been done in the field of sepsis.
Nonetheless , NLC dispersions present low viscosity , which is non-attractive for cutaneous application.
Nonetheless , no previous study has explored the association between serum klotho and fractures.
Nonetheless , no single gene will convey a phenotype like longevity.
Nonetheless , overall satisfaction was high.
Nonetheless , recent evidence suggests that sHSPs are more than molecular chaperones with merely auxiliary role.
Nonetheless , sexual dysfunctions especially in elderly people are poor investigated.
Nonetheless , significant positive associations with subsequent independent replication studies have been scarce.
Nonetheless , studies in this area so far are few.
Nonetheless , subjects ' levels of specific Bmem cells and specific IgG were weakly correlated.
Nonetheless , testosterone drugs have exhibited extraordinary commercial success and their pharmaceutical sales are steadily rising.
Nonetheless , the altered network density in the elderly severely compromises the usefulness of network analysis to study the aging brain.
Nonetheless , the cost effectiveness remained acceptable within the limits that were investigated.
Nonetheless , the effects of SIRT1 variants on MI risk remain poorly understood.
Nonetheless , the indications for renal biopsy are still controversial.
Nonetheless , the literature review has provided a mentoring definition , program models , desired characteristics of nurse mentors , and barriers to mentoring programs.
Nonetheless , the mechanisms underlying these aging-related metabolic disorders are unknown.
Nonetheless , the @number@ factors were highly correlated ( r range @number@ to @number@ ) .
Nonetheless , the proportion of foreign-born employees was positively associated with independent facility quality ratings.
Nonetheless , the resection range for middle-third gastric cancer cases and the extent of LN dissection at early stages remains controversial.
Nonetheless , the retina persists in a state of chronic inflammation and increased expression of certain cytokines and inflammasomes is observed.
Nonetheless these differences had no impact on the prevalence of GAD in three group comparisons.
Nonetheless , the source of this age-related RM deficit remains unspecified.
Nonetheless , the tissue-specific role of JNK1-activation in the development of the metabolic syndrome has been poorly defined so far.
Nonetheless , the type and closeness of the relationship between the caregiver and the care recipient can lessen caregiver depression.
Nonetheless , this review provides a basis for future research on ADRs that contribute to nutrient deficiencies.
Nonetheless , type of community of residence as well as individual and social resources contributed more to PTS symptoms than did the participants ' age.
Nonetheless , understanding aging-induced renal changes may help to prevent life-threatening kidney disease.
Nonetheless , when outcomes for only older adults were considered , phonological awareness and processing speed explained significant proportions of variance in serial recall accuracy.
Nonetheless , α-Klotho is also expressed in the brain parenchyma.
None : The microvasculature is critical in the control of blood flow.
None : The presence of only small amounts of misfolded protein is an indication of a healthy proteome.
None : There is increasing need to understand patient outcomes in osteoporosis.
None : The study of the health status in long-living individuals ( LLIs ) may help identifying health-span and life-span determinants.
None : This paper charted the cognitive and behavioural profiles from toddlerhood to middle childhood in @number@ children diagnosed with ASD at 24-months.
None : Traumatic brain injury ( TBI ) is a widespread cause of neurologic disability , with > 70% of cases being mild in severity.
No neuroimaging study has assessed the age- and menopause-related changes on brain activation areas associated with sexual arousal in menopausal women.
None : Variabilité phénotypique dans la maladie de Krabbe au cours de la vie du patient.
None : Vitamin D deficiency was common in older adults from a country with adequate sun exposure.
No new bleeding from untreated aneurysms was observed ; no retreatment after previous coiling was performed.
None : WHY THE COHORT WAS SET UP ? : CONSTANCES is a general-purpose cohort with a focus on occupational and environmental factors.
None : Winter weather conditions may negatively influence participation of older adults in daily physical activity ( PA ) .
No new neurologic deficit occurred in patients with a patent bypass during the follow-up period ( median @number@ ± @number@ months ) .
Non-fertile oocytes can lead to time-dependent processes of aging , which will affect the results of human spermatozoa examination.
Non-frail subjects did not significantly improve in these measures.
Nongenetic factors explained @percent@ and @percent@ of MR-pro-ADM and ADM expression variability , respectively.
Non-genetic factors , particularly lifestyle , clearly affect the development of age-related diseases and affect health and lifespan in the general population.
NonHispanic black men had greater odds of nocturia even when controlling for other factors.
Non-Hispanic Black or Hispanic / Latina women comprise half of the cohort.
Non-Hispanic white ( NHW ) and NHB had lower levels of Mn than Hispanics ( HISP ) and NHAS.
Non-Hispanic Whites comprised @percent@ , non-Hispanic Blacks @percent@ , and Hispanics @percent@ of the sample.
Non-Hispanic whites with greater insomnia severity displayed lower pressure pain thresholds and pain inhibition.
Non-HIV comorbidities relating to health habits-diabetes , hypertension , liver disease ( hepatitis C ) , renal insufficiency-are common among PLWH.
Non-Hodgkin Lymphoma ( NHL ) occurs worldwide although there is notable geographical variation in incidence and subtype distribution.
Nonhormone therapy trials with antidepressants or gabapentin for hot flash relief are promising.
Nonhuman primate studies suggest that CR may have similar effects in longer-lived species.
Non-infectious inflammatory disease was found in @number@ patients.
Non-intervention studies that were longitudinal or cross-sectional with able-bodied controls that were at minimum matched on chronological age were included for review.
Noninvasive assessment of skeletal muscle myosin heavy chain expression in trained and untrained men.
Noninvasive central BP is likely better than the conventional brachial BP in association with target organ damages and long term cardiovascular outcomes.
Non-invasive characterization of HD-related phenotype changes is important for monitoring progression of pathological processes and possible effects of interventions.
Non-invasive detection is therefore a high priority research endeavor.
Non-invasive detection of colorectal cancer with blood-based markers is a critical clinical need.
Non-invasive evaluation of cell reprogramming by advanced image analysis is required to maintain the quality of cells intended for regenerative medicine.
Non-invasive in vivo neutron activation analysis ( NAA ) was used to measure the fluorine concentration in @number@ people in Hamilton , Ontario , Canada.
Non-invasive lung ventilation ( NLV ) is a main method of treatment.
Non-invasively measured blood pressure , knee angle , respiratory airflow and mouth pressure were continuously registered.
Noninvasive maximum urinary flow decreased significantly with age ( @number@ vs @number@ ml per second , p = 0.002 ) .
Non-invasive measurements included tonometry and pulse wave analysis.
Non-invasive measurements of heart rate and blood pressure were obtained during @number@ min of supine rest.
Non-invasive methods of measuring this directionality may thus provide information related to aging processes.
Non-invasive nanotechnologies can assess molecular changes in the lens , vitreous , and macula that predate visible pathology.
Non-invasive nanotechnologies will enable a paradigm shift from disease detection on a cellular level to a sub-cellular molecular level.
Noninvasive procedural dermatology has evolved rapidly during the past decade.
Noninvasive tear film breakup time was measured using a new method based on a corneal topographer equipped with a modified scan software.
Non-invasive topical agents are largely ineffective at reducing their appearance.
Non-invasive treatments are ideal for busy patients seeking minimal recovery time and so called lunch-time procedures.
Non-ischemic naïve , OVX and RS rats were used as controls.
Non-linear associations with multiple falls were found for gait speed P = @number@ cadence P = @number@ and step time variability P = @number@
Nonlinear fitting routines and equations were used to calculate mean diffusion ( MD ) and mean kurtosis ( MK ) .
Non-linear measures of regularity ( ApEn ) and coupling ( Cross-ApEn ) were also used.
Nonlinear measures such as complexity and fractal scaling properties derived from @number@ h heart rate dynamics of healthy subjects vary from childhood to old age.
Non-linear mixed effect modelling was undertaken in Phoenix @number@ ( Certara ) utilizing backward deletion and forward inclusion of covariates from fully parameterized models.
Nonlinear models revealed that each modality exhibits unique age-related effects and sex differences.
Non-linear optical microscopy is becoming popular as a non-invasive in vivo imaging modality in dermatology.
Nonlinear Principal Component Analysis was applied for the first time to conduct an integrated analysis of the three data sets.
Nonlinear regression analysis was performed to assess the effect of aging on these 2DSTE parameters.
Non-linear trends could indicate early- or late-life gene regulatory processes.
Non-Maintainers additionally declined in Executive Functioning but not Processing Speed.
Nonmedical needs are intricately linked to health.
Non-melanoma skin cancers are a common reality worldwide.
Nonmotor symptoms must be provided high importance as they substantially worsen the quality of life.
Nonmutated TREM2 dysregulation occurs in AD brain.
Non-native protein conformers generated by mutation or chemical damage template aggregation of wild-type , undamaged polypeptides in diseases ranging from amyotrophic lateral sclerosis to cancer.
No nominally significant effects were found.
No non-additive interaction effects were seen.
No non-donor patient survived.
NonO / p54nrb and PSF are multifunctional hnRNPs typically found as a complex exclusively within the nuclei of all mammalian cells.
Nonoperative treatments such as activity modification , immobilization , night splints , and physical therapy have good outcomes for the majority of patients.
NO notably decreased with decreasing 25 ( OH ) D concentration in patients.
Non-parametric analyses were employed. p < @number@ was considered significant.
Non-parametric bootstrapping to estimate mediation effects suggests that HPAA activity mediates the effect of child mortality on TL.
Nonparametric correlations adjusted for demographics , comorbidities , muscle strength , and knee pain assessed associations of time to walk with GMV.
Non-parametric Friedman analysis was conducted to verify trends in the outcome measures.
Nonparametric mixed effects models estimated the average maternal weight trajectory and the corresponding aging-related progression through @number@ years after birth.
Nonparametric statistical analysis and nonlinear piecewise linear / quadratic regression were used to analyse the data.
Non-parametric tests were used to compare groups.
Non-partnered individuals with multimorbidity and those not sharing a home with their partner demonstrated impaired role functioning.
Nonpathological cognitive declines occur with aging and negatively affect everyday functioning and reduce quality of life.
Non-pharmacological interventions addressing the needs of older adults are important for reducing medication burden and possible drug interactions.
Non-pharmacological interventions were reported to be used in @percent@ ( n = @number@ ) of care homes.
Non-pharmacological management is important as no disease-specific pharmacological treatment for FTD is currently available.
Non-pharmacological treatments are the preferred initial approach to managing these symptoms but data in support of these are scarce.
Nonpharmacological treatments for depressive symptoms that enhance symptom recognition in older African Americans can also reduce their functional difficulties with daily living activities.
Non-pharmacologic approaches should be used first line , although several exceptions are discussed.
Non-pharmacologic approaches with the strongest evidence base involve family care giver interventions.
Non-physical markers were associated only with unfavourable discharge ( p < @number@ ) .
Nonpooling propensity score matching substantially reduced the differences , but neither IV approach satisfactorily reduced the differences.
Nonpregnant women were age-matched , nulliparous , nonsmoking , without family history of cardiovascular disease.
Non-prescribed supplements were used by @number@ ( @percent@ ) patients.
Non-prescribed supplement was defined as a supplement that is not usually prescribed by a medical practitioner.
Non-professional disabled respondents with less well-educated parents had lower educational attainment than non-disabled respondents.
Nonquantitative studies indicate that the cerebellum is neuropathologically affected in Alzheimer's disease ; however , no quantitative studies on the subject have yet been conducted.
Non-responders to type @number@ phosphodiesterase inhibitors or patients receiving regular treatment with nitrate , anticoagulants , androgens , and anti-androgens were excluded.
Non-response weighting adjustment did not improve generalizability.
Nonresponsiveness was not apparent in any subject , as a positive adaptive response on at least one training outcome was apparent in every subject.
Non-RPE components of the RPE-Bruch's membrane-choroid-sclera complex were major contributors of vascular endothelial growth factor-A ( VEGF-A ) .
Non-sedating new-generation antihistamines are the mainstay treatment of CSU for the elderly.
Nonselective or serotonergic receptor affinity was not associated with an increased risk of depressive symptoms or syndromes independent of high lipid solubility.
Non-selective β-blocker use was associated with lower mean homocysteine levels ( @number@ vs. @number@ p = @number@ ) .
Nonshared environmental influences were time-specific.
Non-significant aggravations in QoL with longer time since diagnosis were observed in very young and very old cancer survivors.
Non-significant increases in macronutrients were also noted for the average daily intakes.
Non-slip socks do not possess the properties of adequate footwear and have the potential to spread infection.
Non-spouse family members were more likely to be caring for women and unmarried individuals.
Non-statin therapies could be viable options in this population if more was understood about their ability to lower ASCVD risk and safety profiles.
Nonsteroidal anti-inflammatory drug ( NSAID ) use , fiber , folic acid , and calcium have been associated with reduced risk of SPs.
Nonsteroidal anti-inflammatory drugs ( NSAIDs ) are frequently used due to perceived safety , relatively low cost and over-the-counter availability.
Nonsteroidal selective androgen receptor modulators ( SARMs ) are a new class of anabolic agents that bind the androgen receptor and exhibit tissue selectivity.
Non-stressed controls had normative behaviors although the fluoxetine-treated controls had higher neurogenesis rates.
Nonsurgical complications were mainly ocular ( @number@ percent ) .
Nonsurgical techniques that target the dynamic anatomical relationships existing in the midface can improve rejuvenation outcomes in this commonly augmented region.
Nonsurgical therapies are preferred for muscle injuries and osteoarthritis of the lumbar spine.
Nonsurgical treatment may be beneficial , but surgical options , including arthroscopy , osteotomy , and arthroplasty , should be considered if nonsurgical management fails.
Nonsurvivors had significantly higher FS compared to survivors ( @number@ ± @number@ vs @number@ ± @number@ ) .
Non-teachers that noticed the vocal aging had difficulties with the socio-emotional and physical aspects.
Nontransformed cell types within the microenvironment continuously coevolve with tumor cells to promote tumorigenesis.
Nontransgenic mouse lens proteins incubated with purified wt-APH in vitro resulted in a > 20% increase in LMW peptides.
Non-transportation rates following a fall ranged from @percent@ to @percent@.
Non-treatment-seeking young adults at risk for drug problems ( n = @number@ ) were assessed for readiness to change.
Nontuberculous mycobacteria ( NTM ) are important emerging cystic fibrosis ( CF ) pathogens.
Nonunion prediction requires knowledge of @number@ patient variables but predictive accuracy is currently comparable to the Framingham cardiovascular risk prediction.
Non-users included women with an intrauterine device ( IUD ) or no hormonal contraception.
Non-users were matched to @number@ statin users.
Nonvalidated intermediary biomarkers of risk may possibly predict clinical outcomes , but more research is needed to confirm the associations between cause and effect.
Non-valvular atrial fibrillation ( NVAF ) significantly contributes to the burden of stroke , particularly in elderly patients.
Non-verbal social communication is realized through our ability to read and understand information present in other people's actions.
Non-viable osteocytes were heterogeneously distributed forming islets of varying size surrounded by the intact and viable parts of the LCP.
Non-vitamin-K-oral anticoagulants should not be used in CeAD outside a properly designed trial , as experience with these drugs in CeAD-patients is limited.
Non-white children had lower survival rates than white children , and these survival patterns persisted over the four-decade span of the study.
Nonwrinkled-skin fibroblasts had higher synthesis and were unaffected by the extract.
Nonxenografted animal models have not been comparatively evaluated for how well they resemble the changes seen in human skin.
No obvious association was observed between the development of wine sensory characteristics and the evolution of dissolved oxygen in wine.
No obvious laws were found in other syndrome types.
No obvious laws were found in other syndrome types.
No obvious low back pain was observed.
No one inoculum was suitable as an ECO157 surrogate across all intervention treatments used by large abattoirs.
No organ conveys youth and beauty to the extent that skin does.
No , or only small , age effects were observed for working memory , phonemic fluency , learning of visual information , and reaction time.
No other associations between flavonoid classes and risk of T2D were observed.
No other associations were observed.
No other associations were observed.
No other biochemical parameter was significantly altered within either group.
No other biomarkers were associated with OP exposure.
No other cortical networks were correlated with daytime sleepiness.
No other covariates such as age were identified.
No other diabetic vascular complication was found to be associated with low BMD.
No other dietary pattern was associated with the incidence of depression.
No other differences were observed in serum hormone levels between subjects with and without HT ( P > @number@ ) .
No other dual or triple biomarker combination showed a significant improvement of both C-index and IDI.
No other locus in the meta-analysis achieved genome-wide significance.
No other major longevity locus was found.
No other measures of adiposity , including calf intermuscular fat , were associated with mortality.
No other relationships were statistically significant.
No other significant correlations between BREQ-2 and PECC scores were found.
No other significant correlations were observed within the hippocampus or within the thalamus.
No other significant differences were observed in any of the examined organs.
No other significant relationships between ACL and cognition were noted.
No other statistically significant group difference , correlation or group-dependent regression was observed.
No other subcortical structures were independently associated with IQ , suggesting a specific biological link between caudate morphology and intelligence.
No other treatment modalities were used during the period of LIPUS stimulation.
No other variable maintained significance in the presence of Hip ( STR ) / AnkPRO .
No other variables had a statistically significant influence on knowledge and attitudes.
No other variants in the PRNP gene were associated with increased risk for MSA.
No overall association between OH and cognitive performance was seen.
No pain threshold measure showed significant racial differences , whereas several suprathreshold pain measures did.
No partial correlations with treatment success have been found in WM analyses.
No participants discontinued donepezil due to cost.
No participants reported adverse reactions to treatment.
No participants were vitamin A or vitamin E deficient ; @percent@ had low serum zinc levels ( < 70 μg / dL ) .
No participants with < @number@ met the recommended level of physical activity.
No pathogenic expansion was found in MS and control populations , suggesting that C9ORF72 does not play a major role in MS pathogenesis.
No pathogenic mutations were found , suggesting that CHCHD2 gene may not play a major role in our familial Chinese Han ET and PD patients.
No patient reported unwanted side effects.
No patient required dissolution with hyaluronidase.
No patient required reoperation for hemostasis or evacuation.
No patients got new-onset diabetes and pancreatic pseudocyst.
No patients had worsening pain or progression of disability requiring surgery.
No patients ( @percent@ ) experienced pneumothorax ( PNX ) , confirmed at CXR.
No patients revealed paternal disomy among @number@ patients with PHP-Ib.
No patient suffered any adverse effects.
No peculiar EEG features have been associated with 22q13 deletion syndrome to date.
No perioperative hospital death was documented.
No permanent approach-related complications occurred.
No permeability differences were observed for renal function , age , race , sex , or BMI.
No person older than @number@ years displayed a full profile.
No point mutations were identified on FTD cohort.
No pooling was possible for HPV infection studies due to small numbers.
No population group differences were found regarding long sleep prevalence.
No positive changes were detected in attitude towards aging and body composition measures in any groups.
No positive correlation between ROS production and intracellular HSP70 levels was found for groups of young people and nonagenarians.
No postoperative infection , hypopigmentation , or scarring occurred after IPL and AFL treatments.
No preferential benefit was found for individuals in the MIP + TTC group on cognition , gait , or balance measures.
No pre- versus post-CEA changes were significant in the contralateral middle cerebral artery or posterior segments.
No previous studies have examined all of these symptoms together.
No previous study has explored differences between these two groups.
No previous study has investigated vitamin D homeostasis in post-partum thyroiditis.
No previous study has investigated whether cognition is related to ghrelin in the non-demented elderly.
No previous study has systematically tested the trend of age stereotypes over more than @number@ years , due to lack of suitable data.
No primary or secondary preventive treatments for AD have been approved.
No prior work has examined this in mild cognitive impairment ( MCI ) .
No program had a significant influence on the participant's cognitive performance , while different effects on the sample ' fitness levels were observed.
No progressive course was noted.
No prominent sSNPs have been recorded in three key T2D-related genes ( GCGR , PPARGC1A , IGF1 ) .
No pronounced signs of dementia were observed.
No protective effects of higher education were found on any of the six cognitive measures.
No publication bias was found.
No published case series for different valve positions exist regarding suitability of the new Edwards Sapien @number@ ( Edwards Lifesciences Co. )
No race-ethnic difference in FeNO levels was evident for adults 20-79 years.
No racial difference in training gain was identified for speed training.
Noradrenalin , dopamine and other metabolites were quantified by HPLC analysis.
Noradrenaline increased ( P < @number@ ) only during G3.
No randomised controlled trials were identified.
No randomized controlled trial evidence is available on the risk of hospitalization for stroke with use of typical antipsychotics in the elderly.
No randomized controlled trial was found.
Nor did the size of the left atrium exhibit any correlation with BSA-related LAA length.
Nor does the risk of social isolation affect the likelihood of an adverse outcome.
No recipes or advice on use of nuts were provided.
No reciprocal relationship was found between caregiving and labour force participation , but gender differences were evident.
No recurrence has been noted for @number@ years post-operatively.
No recurrence occurred in the subsequent two years , but long-time monitoring is still necessary for the prophylaxis of colorectal cancer.
No recurrence was found in all of @number@ cases with follow-up of @number@ to @number@ months ( median : @number@ months ) .
No recurrence was performed in the @number@ years ' follow-up in our case.
No relationship between height and cognition was found for females.
No relationship between the other cognitive domains and brain or hippocampal volume was found.
No relationship of anti-ox LDL level with cognition , hypertension , metabolic syndrome , inflammation indicators and serum lipid levels was observed.
No relationship of multimorbidity with cognitive functioning was established.
No relationships were observed between BMI and other white matter tracts or cognition after controlling for demographic variables.
No relationships were observed with verbal memory or global cognitive function.
No relationship was detected between retinal thickness and retinal sensitivity in the healthy macula.
No relationship was found between hip BMD or fracture with renal function ( p = @number@ ) .
No relationship was found between pancreatic adipose tissue infiltration and beta cell function , regardless of glucose tolerance status.
No relationship was found between sociocognitive activity and episodic memory for either younger or older adults.
No relationship was found when correlated to muscle strength or agility.
No relationship was found with coworker and supervisor social support.
No relationship was observed between oestradiol or DHEA and MD.
No relationship was observed between pubertal status and FA.
No remarkable changes were observed in choline-containing compounds concentration at any time.
No restrictions were placed on sample size , language , or publication type or date.
NO RESULTS : The study population included @number@ participants.
Normal ageing hinders SC proliferation and differentiation , and is associated with increased expression of a number of pro-apoptotic factors in skeletal muscle.
Normal ageing is associated with characteristic changes in brain microstructure.
Normal ageing is associated with diverse physiological changes in all organ systems but the rate and extent of these changes vary markedly among individuals.
Normal ageing is often accompanied by loss of appetite and decrease in food intake.
Normal aging and Alzheimer's disease ( AD ) cause profound changes in the brain's structure and function.
Normal aging and IPD can be associated with a WM decline.
Normal aging is accompanied by a decline in CNS function and reduced neurogenesis.
Normal aging is accompanied by global as well as regional structural changes.
Normal aging is accompanied by various cognitive functional declines.
Normal aging is associated with deficits in episodic memory processes.
Normal aging is associated with greater decline in associative memory relative to item memory due to impaired recollection.
Normal aging is usually accompanied by greater memory decline for associations than for single items.
Normal aging of the nervous system is associated with some degree of decline in a number of cognitive functions.
Normal aging results in a predictable decrease in glomerular filtration rate ( GFR ) , and low GFR is associated with worsened survival.
Normal anatomy and sonographic characteristics of the MGT have also been summarized.
Normal and abnormal differences in sustained visual attention have long been of interest to scientists , educators , and clinicians.
Normal and pathological aging are therefore separate developments.
Normal cells enter a senescent state upon aberrant oncogenic signals and this response inhibits tumor initiation and progression.
Normal closing age for synchondroses was defined as soon as a complete ossification rate of @percent@ or more per age category was achieved.
Normal cognitive aging compromises the ability to form and retrieve associations among features of a memory episode.
Normal controls produced significantly more exemplars and AD patients produced fewer animal names than the other groups.
Normal detrusor activity was recorded in @number@ patients on pressure flow evaluation.
Normal developmental changes in different brain areas alter tissue water content , which can be assessed by magnetic resonance ( MR ) T2 relaxometry.
Normal elderly showed greater threshold change by hyperpolarizing pulse than younger subjects at high target level , likely reflecting decrease of axon diameters.
Normal fluid status ( dry weight ) can be identified by hydration markers established in the healthy population.
Normal human aging is associated with declining motor control and function.
Normal human cells have a replicative life span and therefore senesce.
Normal human dermal fibroblasts were treated with Eucalyptus globulus at concentrations ranging from @number@ to @number@ μg / mL after UVB or non-UVB irradiation.
Normal human kidney showed specific staining for PAPP-A in glomeruli , and this staining was markedly increased in diabetic kidney.
Normal individual reaches peak bone mass at age between @number@ and @number@ years , and thereafter bone mass declines with age in both genders.
Normalising muscle mass to height squared is often suggested as a solution for this.
Normality of variables distribution was checked and found satisfactorily.
Normalization is required to compare pre- and post-RT SPECT images because the uptake pattern is changed due to the breathing level.
Normalization of relaxation rates to strength did not affect the influence of age or sex.
Normalization of testosterone in aging hypogonadal men has a beneficial effect on the above pathologies.
Normalization of this increased ratio by 4R-T-specific silencing results in recovery of the normal phenotype.
Normalization was applied on the mean of SPECT counts in regions of the myocardium receiving less than @number@ Gy.
Normalization with optical intensity of ONL , all areas , or image quality index is recommended.
Normalizing equations , generated using Passing-Bablok regression , were used to generate harmonized values , which were used to derive standardized , age-specific reference ranges.
Normal language acquisition is a process that unfolds with amazing speed primarily in the first years of life.
Normal levels of CD4 + CD25 ( hi ) and FoxP3 ( forkhead box P3 ) are restored.
Normally , harmonics at integer multiples of a fundamental frequency are perceived as one sound with a pitch corresponding to the fundamental frequency.
Normally , intestinal GLP-1 compensates for the lack of α cell-derived GLP-1.
Normally , it is extremely difficult to fabricate a filter structure on a normal glass plate by using a conventional fabrication method.
Normally , there is the balance between oxidative and reductive processes in the organism.
Normally , upon formation of DNA double strand breaks ATM is autophosphorylated and its active form phospho-ATM ( P-ATM ) appears.
Normal mice showed catagen-telogen and telogen-anagen transitions at @number@ and 8-9 weeks old , respectively.
Normal NAA / Cr levels in the frontal voxel differentiated DLB patients with preserved hippocampal volumes from AD patients.
Normal physiological conditions are characterized by equilibrium of oxidative and antioxidative mechanisms.
Normal red blood cells ( RBCs ) and lysed RBCs ( dysfunctional cells ) are used as model cells.
Normal renal proximal tubular cells have low levels of macroautophagy , but high basal levels of CMA activity.
Normal tissue can bypass PARP1- or DNA-PKcs inhibitor-induced genotoxic lesions via homologous recombination-mediated DNA DSB repair.
Normal weight or overweight and waist circumference of @number@ cm or less were also associated with independent aging.
Normative adult age-related decrements are well documented for many diverse forms of effortful cognitive processing.
Normative age-related data may be necessary to properly interpret VEMP recordings in a clinical setting when evaluating aging populations.
Normative data adjusted for age were reported in American healthy individuals older than @number@
Normative data stratified according to estimated quality of education are presented.
Normative data were stratified by ; 5-year age groups , sex and ethnicity.
Normative values regarding them should be prepared with adjustment for gender.
Normative values were calculated across countries and for different age groups.
Normograms can provide a reference guide for physicians to counsel infertile women.
Normotensive older females showed a higher performance in the one-leg stand test and six-minute walk test compared with hypertensive older females.
Norms are reported for all participants , and reliability analyses were conducted using data from @number@ participants.
Norms were presented on age-education scaled scores.
Norms were stratified by sex and age left school in 5-year age groups.
Noroxycodone AUC ( ∞ ) was increased in the oldest group compared with patients aged 20-40 and 60-70 years ( p < @number@ ) .
Nor should it be provided or withheld on the basis of moral judgements about patients ' values or lifestyles.
North Queensland was the site of several outbreaks of locally-acquired dengue virus infection involving all @number@ serotypes.
Norway has an extensive welfare system which may provide adolescents with many options and high levels of flexibility in terms of pathways to adulthood.
NOS3 / eNOS function is tightly regulated at both the transcriptional and post-transcriptional levels to maintain normal vascular function.
No scarring or postinflammatory hyper- or hypopigmentation was observed.
No scientific paper describes how sotolon might be involved in the Madeira off-flavor found in aged beers.
No senior surgeon performed below the younger surgeons on all @number@ tasks.
No sensitization to Cor a @number@ or Cor a @number@ was found in patients with only an OAS.
No serious ADRs were recorded ; a total of @number@ ADRs were recorded for @number@ of @number@ patients.
No serious adverse effects were reported.
No serious adverse event occurred.
No serious adverse events occurred.
No serious adverse events were reported.
No serious adverse events were reported.
No serious adverse event was recorded.
No serious adverse reactions were observed and both materials were tolerable in most cases.
No serious operative complications including facial nerve palsy and skin slough were found.
No serious side-effects were reported.
No serious side effect was observed.
No severe adverse events were reported for bisphosphonates treatment.
No severe toxicity was encountered.
No sex differences were found for fine motor movement.
No sex effect was observed.
No side effects were noted throughout the study.
No side effects were observed.
No side effects were reported throughout the trial.
No signaling-mediated regulation of receptor maturation could therefore be demonstrated.
No signal of harm was seen , and a significant improvement of QOL and less ED visits without hospitalization were observed.
No significant age-dependent differences were identified.
No significant alteration in the expression of urokinase plasminogen activator ( uPA ) is detected.
No significant alterations were observed for resting blood pressure , triglycerides , or C-reactive protein.
No significant association between the ' High-protein ' dietary pattern scores and the plasma carotenoids was found.
No significant association for nonfatal CVD was observed.
No significant associations of rs16944 genotype were found with verbal or performance IQ.
No significant associations were detected between 25 ( OH ) D and absolute loss of trunk lean mass or total body lean mass.
No significant associations were detected in women.
No significant associations were found among women in any analysis , highlighting potential sex differences in internalizing-related telomere biology.
No significant associations were found between demographics and facility characteristics.
No significant associations were found between lymphocyte or monocyte counts and incident CHD.
No significant associations were found between vitamin K intake and bone biochemical markers.
No significant associations were found in the other countries.
No significant associations were observed among intakes of EPA , DHA , EPA + DHA , or fish.
No significant associations were observed between consumption of diet sodas or noncarbonated SSBs and telomere length.
No significant associations were observed between the Zung or Greene Scale scores and levels of androgens.
No significant associations were observed for black carbon.
No significant associations with body mass index or smoking were found.
No significant associations with white matter or processing speed were observed.
No significant association was detected for unselected OC cases ( OR , @number@ @percent@ CI , @number@.57-5.08 ; P = @number@ ) .
No significant association was found between APOE or TOMM40 genotypes and the risk of developing sIBM.
No significant association was found between IGF-1 levels and duration of normal mental state ( p = @number@ ) .
No significant association was found between longitudinal change in BRS and attentional and executive changes.
No significant association was found between SCD and episodic memory.
No significant association was found between SV and PP in the old group.
No significant association was found between TAS and the total ORAC value of ARF determined from the quantitative 24-h diet recalls.
No significant association was found between Total-E2 and dementia.
No significant association was found between vegetable intake and bone mass.
No significant association was found between white matter alterations and cognitive outcome.
No significant association was found for total-testosterone.
No significant association was observed among ASA , which was likely due to the small sample size of the ASA participants.
No significant association was observed between frailty and DTP , after adjustment for covariates.
No significant association was reported between 25 ( OH ) D levels and frailty.
No significant association with daily dairy product intake , vitamin D or Se supplements was observed.
No significant behavioral responses to either METH pretreatment dose were observed for the D2 adolescent studies or either @number@ age group.
No significant between-subject effects were found.
No significant change ( P > 0.05 ) in any of the variables studied was found following the exercise intervention compared with the standard-care group.
No significant changes , but GBE-associated numerical non-significant trends were found after 6-month treatment for dual-task-related gait velocity and stride time variability.
No significant changes from baseline were observed in total and trabecular BMD , nor in cortical or trabecular micro-architecture and neither in bone resorption.
No significant changes in insulin-stimulated Rd was observed ( b = @number@.01mg / min / m ( @number@ ) , p = @number@ ) .
No significant changes in mean depression scores were observed.
No significant changes in PMCA expression and localization with aging or neuropathology were found.
No significant changes in pure-tone test or tympanometry were noted.
No significant changes in small collagen fibers were identified.
No significant changes in the use of drugs was found in any of the groups.
No significant changes were found in the contralateral eye.
No significant changes were observed for sclerostin.
No significant changes were observed for the CG.
No significant changes were observed in moisturizing.
No significant changes were observed in the control group.
No significant changes were observed in the ME group after @number@ weeks of training.
No significant changes were observed in the plasma.
No significant changes were seen in mental component scores by fat change location or severity.
No significant change was found in DM2 + Met.
No significant change was noticed in red-light group.
No significant change was noticed in stem and other cell counts.
No significant change was noticed in the L a b values in both groups.
No significant change was observed in Ea velocity and E / Ea ratio with exercise.
No significant change was observed in HIGH or LOW , neither in male nor female subjects.
No significant change was observed in other plasma antioxidants such as superoxide dismutase and catalase.
No significant change was observed in the serum markers of bone formation compared to baseline measurements for either group.
No significant combined effect of the two polymorphisms was found.
No significant correlation occurs with the common diffusion parameters.
No significant correlation of SUR to age was found in subcortical regions.
No significant correlations between E2 levels and OS markers were detected.
No significant correlations between performance on the cognitive tests and white matter volume were found.
No significant correlations were found between all variables of TMS and reactive / proactive balance and between all variables of spinal mobility and balance.
No significant correlations were found between muscle strength results and RMA or age.
No significant correlations were found between other aspects of cognition and CSF levels in CTR or AD patients.
No significant correlations were found with performance on tests of frontal function ( WCST , phonemic fluency , and backward digit span ) .
No significant correlations were observed.
No significant correlations were observed between QoL-ADp and patient variables or QoL-ADc.
No significant correlation was found for age-related changes in rCBV and rCBF.
No significant correlation was found with the GDS-15.
No significant correlation was observed between plasma MMP-2 and MMP-9 and ascending aorta diameter.
No significant cross-jurisdictional \ "ecology \ " or inter-relatedness was found between the variation in LTC bed supply and any of the examined variables.
No significant decreases in BMI were observed after the aerobic training in either group.
No significant difference has been detected between the @number@ groups at baseline.
No significant difference in antibiotic administration was found between groups , however.
No significant difference in NGF mRNA expression between the two groups was detected ( p > 0.05 ) .
No significant difference in platelet aggregation values were noted between T1 and T2 , while similar aggregation values were recorded at T3.
No significant difference in surgical complications was observed between younger and elderly patients and considering the different procedures.
No significant difference in survival was measured between patients according to CCI score ( P = 0.13 ) .
No significant difference in terms of demographic characteristics , risk for osteoporosis , and past history of VitD supplementation was measured.
No significant difference in the CIMSE values was found between the two groups.
No significant difference in the frequency of POPF , delayed gastric emptying , or intra-abdominal abscess was found between groups.
No significant difference of skin perfusion was observed between UV-exposed and UV-unexposed areas.
No significant difference on bach1 and CD14 mRNA levels was observed.
No significant differences among groups were shown at @number@ h.
No significant differences between groups were found in habitual intensity level for pitch , hoarseness , roughness , and breathiness.
No significant differences between groups were found regarding treatment compliance.
No significant differences between the two groups were observed regarding duration of surgery , surgical success rates , postoperative complications and hospitalization time.
No significant differences could be found between the two groups in lipid profile levels.
No significant differences emerged for the correctness of the performance and significant differences were not correlated with depression or cognitive impairment.
No significant differences emerged for the secondary outcomes investigated , and no serious adverse effects were reported.
No significant differences existed between groups for any variable at baseline ( p > @number@ ) .
No significant differences existed between groups @number@ and @number@ or groups @number@ and @number@
No significant differences existed in serum lipids , glucose , uric acid , creatinine and blood urea nitrogen levels between the AF and control groups.
No significant differences in any of the FD measures were observed between control and ALS patients.
No significant differences in attitude were observed based on years of experience or intensity of use.
No significant differences in CRF were observed between age groups.
No significant differences in decline of muscle strength and quality were found.
No significant differences in effect were found based on participant or intervention characteristics.
No significant differences in heart rate or abdominal discomfort were observed between treatments.
No significant differences in HRQoL scores were noted among demographic , diagnosis , or transplant factors.
No significant differences in manometric parameters or HRQOL were detected among the three groups.
No significant differences in microhardness were observed among the restorative materials on enamel and dentin.
No significant differences in plasma NOx or nitrotyrosine concentration existed between adult and elderly patients.
No significant differences in roughness could be determined between the materials , neither before nor after testing ( p < @number@ ) .
No significant differences in stiffness were observed between older fibromyalgia subjects and controls.
No significant differences in TEE , physical activity EE , and PYY were noted between baseline and after the intervention.
No significant differences in the frequency of TLR2 alleles , genotypes , and haplotypes in the AD cases were detected compared with the controls.
No significant differences in the incidence or severity of airbag-related UEI were found between young drivers and older driver age groups.
No significant differences in the length of wrinkles were recorded.
No significant differences in the number of C4A , C4B and C4S were detected.
No significant differences in the response of the pelvis to the LLIs were found between the age groups.
No significant differences in traditional CV risk factors or in medication use were observed between the two groups.
No significant differences of histological type and Ki-67 LI were found.
No significant differences of mirror movements between dominant and non-dominant hand , or left- and right-handed participants , were found.
No significant differences of the four FOXP2 polymorphisms in genotype distribution and allele frequency between FTLD and controls were observed.
No significant differences were found across dynapenia and obesity status for all other metabolic components ( P > @number@ ) .
No significant differences were found between both feet.
No significant differences were found between chondrocytes and PBL in control subjects.
No significant differences were found between dental and chronological age in boys with cerebral palsy , mental retardation , or Down syndrome.
No significant differences were found between groups for all other variables.
No significant differences were found between groups in terms of self-perception of weight.
No significant differences were found between groups when considering microbleed presence.
No significant differences were found between men and women.
No significant differences were found between @number@ and @percent@ conditions in onset times of all postural muscles , and latency and amplitude of P300.
No significant differences were found between pre / postassessment for oculomotor score or total Simulator Sickness Questionnaire score.
No significant differences were found between sexes in any age group.
No significant differences were found between the predicted and real mortality rates.
No significant differences were found between the three conditions for the young group with regard to accuracy and vocal reaction times.
No significant differences were found for either salivary α-amylase activities or Wisconsin Card Sorting Test scores before and after walking.
No significant differences were found for PWV , AA , AixBrach and AixAo.
No significant differences were found for the posterior and ventral DMN.
No significant differences were found in ARI ( t ) due to aging.
No significant differences were found in brain volumes and lesion load in both groups when comparing data acquired at baseline and after cCR or aCT.
No significant differences were found in hand grip strength or reported physical activity.
No significant differences were found in SOD activity between the subgroups with different PANSS scores.
No significant differences were found in the whole-brain measures.
No significant differences were identified between the health professional groups or between the student groups.
No significant differences were identified for the other indicators.
No significant differences were identified in the outcomes reported for experiment group when compared with controls treated with conventional surgical procedures or rehabilitation programs.
No significant differences were noted in P1 and N1 latencies or IAD ratios.
No significant differences were noticed between age groups either considering total HP 1F and HP 1S allele frequencies or according to HP @date@ genotypes.
No significant differences were observed after lowering of uric acid with rasburicase.
No significant differences were observed between concentric and eccentric-concentric repetitions.
No significant differences were observed between OS and SS twins , neither for the sex-specific cancers nor for cancer at all sites.
No significant differences were observed between photographs @number@ and @number@ for any of the evaluators.
No significant differences were observed between the materials with respect to cement remnants or IDS after fracture ( p = 0.880 ) .
No significant differences were observed between the two physical intervention groups.
No significant differences were observed from responses regarding LGBT older adults or constraints to sexuality in long term care facilities.
No significant differences were observed in females.
No significant differences were observed in immunohistochemistry profiles between small-cell carcinoma of the esophagus and the lung.
No significant differences were observed in mtDNA genes identified in the array between AD , ND , and MCI subjects except one mt-ND6.
No significant differences were observed in serum ABP levels in all male farmers between the two groups with different fluoride exposure.
No significant differences were observed in the allele frequencies of these variants between patients and controls.
No significant differences were observed in the detection of AV asynchronous speech between the normal-hearing listeners and the cochlear implant recipients.
No significant differences were observed in the frequencies of the three groups studied.
No significant differences were observed in the magnitude of the increases in CG.
No significant differences were seen in scores on the neuropsychological battery of tests between the two groups.
No significant difference was detected between young men and infertility patients for the V-LH allele frequency ( @number@ vs. @percent@ , respectively ) .
No significant difference was evident between groups I and II.
No significant difference was found among erythema and melanin index at baseline , four , and twelve weeks after treatment among the two major groups.
No significant difference was found between age groups for all metrics.
No significant difference was found between the full-crown , inlay , and buccal retainers.
No significant difference was found between the groups in terms of femoral cartilage thicknesses ( all p > @number@ ) .
No significant difference was found between the two groups in terms of oxidative stress markers.
No significant difference was found between two groups in terms of age , gender and dominance.
No significant difference was found for leakage rate in any of the tissue regions.
No significant difference was found in IOP measured with ART.
No significant difference was found in the circulating MAIT cell levels between male and female subjects.
No significant difference was found in the evaluated parameters for the subgroups of patients with and without aura.
No significant difference was found regarding the fracture resistance of the crowns ( P = @number@ ANOVA ) .
No significant difference was noted for hand grip strength or 8-foot walking time.
No significant difference was observed in alpha-1-PI ( + ) and alpha-1-AC ( + ) cells.
No significant difference was observed in the clinical course between CMV-DNA- cases and CMV-DNA + cases with low viral loads.
No significant dose- or concentration-dependent changes in self-reported voice handicap index scores were observed.
No significant effect of adjunctive procedures was found.
No significant effect of gender was found , whereas age was found to be significantly associated with the g-ratio within the white matter.
No significant effect of GSTT1 genotype on mortality was shown in participants with low and high IL-6 level.
No significant effect of methyl nutrients on TLR2 methylation was observed.
No significant effect on flexibility was found.
No significant effects appeared for depression.
No significant effects in favour of interventions on either emotional or functional status , self-efficacy , or social participation were found.
No significant effects on mood or blood pressure were observed.
No significant effects were found for femoral-tibialis posterior PWV or for resting forearm blood flow.
No significant effects were found on explicit intention.
No significant evidence of heterogeneity between studies was observed.
No significant functional loss of magnocellular hypothalamic neurosecretory neurons were found in the SON or PVN in AD.
No significant improvements and differences in QALYs between the three conditions were found.
No significant increase in risk of cardiovascular events , coronary heart disease , or total mortality was observed.
No significant interaction between adiposity measures and the FTO polymorphism in association with LTL was identified for either sex.
No significant interaction effects of sex , dementia , or living conditions were found in these associations.
No significant interactive effects of metformin use with APOE-ε4 , depression , or fasting glucose level were observed.
No significant inter-group difference existed in the incidence of SNs ( P = @number@ ) .
No significant inter-group difference in the frequency of falls was observed during the @number@ months of research.
No significant linear associations were observed between testosterone dose and MCP-1 , sICAM-1 , or hs-CRP ( all p-trend > 0.20 ) .
No significantly different survival rates were found between the three veneer groups.
No significant male age-related increase in DFI or immature chromatin was demonstrable for these patients.
No significant medical or surgical morbidity was observed.
No significant methylation-genotype interactions were found.
No significant migration was observed after @number@ h incubation with 15-epi-LXA4.
No significant morbidities occurred.
No significant overall effect of diagnosis on the rate of decline was detected.
No significant relationship between low versus high baseline HbA1c levels and brain changes was found.
No significant relationships between other sleep stages ( N2 , N3 ) and cognitive change were found.
No significant relationship was found between leukoaraiosis score and clinical SBP , clinical DBP , or nocturnal DIP.
No significant relationship was observed between anticholinergic drug use and the main endpoints.
No significant relation with other cognitive domains was observed.
No significant unique environmental correlation was found for depression with other two phenotypes.
No significant VBM WM changes were observed between controls and ALS patients and among the ALS subgroups.
No significant within-group associations were found in cognitively healthy people , patients with mild cognitive impairment , or patients with Alzheimer's disease.
No similar association was evident among participants with low genetic risk.
No similar covariations were observed for aches and PA.
No similar study has been conducted in the world largest and rapidly ageing Chinese population living under distinct environmental condition as the Western populations.
No similar trend was found for other genes.
No single association was verified by an equivalent association in the contralateral eye.
No single-nucleotide polymorphisms reached statistical significance in the AAs.
No single sign or symptom defines TD.
No single test differed significantly across the AD and DLB groups.
No single test is sufficient to determine who should drive and who should not.
No skeletal specific muscle phenotype of pre-frailty was observed.
Nosocomial and healthcare-related OAI increased , with a rise in multidrug-resistant bacteria.
Nosocomial IE patients had an @number@.3-fold and NNHCA-IE patients had @number@.5-fold increase in the risk of mortality compared to CA-IE patients.
Nosocomial infections and antibiotic therapy in combination or alone is leading to gastroenteritis followed by Clostridium associated diarrhoea or antibiotic associated diarrhoea.
Nosocomial infections may originate from contaminated air ventilation systems or water pipes.
No specific exclusion criteria were used.
No statistical associations were found between hypertension , diabetes , dyslipidemia and capsular perforation and the development of ED after TURP.
No statistical association was observed between total AMS scores and any testosterone value.
No statistical difference existed between the two groups ( P > @number@ ) .
No statistical differences were observed between the CRH and UCRH subgroups with respect to age and gender.
No statistical differences were observed regarding these functions compared to those of normal human skin fibroblasts.
No statistical improvements were seen in the control group.
No statistically significant association ( OR = 1.02 , @percent@ C. @date@ .81-1.27 ) of fish consumption with cognitive decline was found.
No statistically significant associations emerged between FA and memory for negative or neutral words.
No statistically significant change of the residual volume was found.
No statistically significant correlation between a history of severe paroxysmal hemiplegic / dystonic episodes and a worse neurological outcome was identified.
No statistically significant correlation was observed between the histological score and the IHC expression of CML.
No statistically significant decline in quality of life with increasing severity of falling injury was identified after a 12-month follow-up period.
No statistically significant difference as concerns the mean weight of the superficial compartments ( @number@.93g vs @number@.73g ) .
No statistically significant difference in condyle / clivus ratio was evident between patients with active and those with inactive CH.
No statistically significant difference in the prevalence of overt thyroid disorders was observed.
No statistically significant difference in these @number@ parameters was observed between the male and female subjects.
No statistically significant difference on changes of SI were seen between the two groups.
No statistically significant differences between before and after surgery were observed in the amount of light received and the amount of activity.
No statistically significant differences in activation of the auditory cortex were found between the MP and EP groups.
No statistically significant differences in the biomarker concentrations in samples obtained from male and female subjects were observed for either MCI or AMC.
No statistically significant differences in the change in mental health functioning occurred.
No statistically significant differences in the primary outcome measures or their correlations were found when using gender or ethnicity as a covariate.
No statistically significant differences were found between daily users and nonusers on volume or shape in the regions of interest.
No statistically significant differences were found between groups for other comorbidities or intraoperative parameters.
No statistically significant differences were found for estradiol ( p = 0.588 ) and cortisol ( p = 0.182 ) levels.
No statistically significant differences were noted between Retinol @number@.2% / LR2412 @percent@ cream and tretinoin @percent@ cream.
No statistically significant differences were observed among treatments in total bench press lifting volume , leg press lifting volume or WAC sprint performance.
No statistically significant difference was found for the genotypic and allelic distributions of the polymorphism in XRCC1.
No statistically significant difference was found in the genotypic and allelic distributions of the polymorphisms in the XPD gene between the groups.
No statistically significant difference was observed in individual radiosensitivity between males and females at either radiation dose.
No statistically significant effect of age , gender and marital status on the SOC levels of U3A students was found.
No statistically significant effect on depressive symptoms was found for physical exercise , skill training , reminiscence , or for multicomponent interventions.
No statistically significant gender differences were identified in any of the data points.
No statistically significant interaction effects between frailty and psychosocial resources were found for either functional decline or mortality.
No statistically significant risk factors emerged in this small sample , but suggestive trends were apparent.
No statistically significant sex differences were found.
No statistical significance was observed for clinical presentations , and BAVM characteristics among age groups.
No statistical significant differences ( p > 0.05 ) due to age was found in N400 characteristics.
No STN size differences were observed between the groups.
No strict cut-off value for these baseline measures was identified to predict clinical outcomes.
No studies as yet have focused on whether residents are influenced by staff use of guidelines derived from the theory of gerotranscendence.
No studies examined functional status.
No studies exist , however , evaluating the impact of this standardization on its predictive ability.
No studies explored pressure sores or quality of life.
No studies have assessed this association using residence-specific estimates of air pollution exposure.
No studies have assessed this hypothesis with a follow-up time reaching beyond childhood.
No studies have described telomere length trajectory and its relationship with COPD progression.
No studies have focused on older workers and long work hours , although the risk of obesity is high among this population group.
No studies have investigated the consequences of such declines in the dairy intakes of Irish older adults and the subsequent effects on vitamin micronutrient status.
No studies have thus far evaluated an association between BACs and breast cancer , however.
No studies , however , have demonstrated how MRI can distinguish CJD from nonprion causes of rapidly progressive dementia ( npRPD ) .
No studies of neuroticism and physical functioning have been conducted on life-span samples.
No studies showed definitive evidence to suggest long-term survival rates improved in patients who underwent PEG placement as compared to those who did not.
No studies to date have assessed the potential associations of genetic variants in FOXA3 with human metabolic outcomes.
No studies to date have investigated the potential link between dysfunctional mitochondrial ATP production and low vitality.
No studies were excluded due to methodological quality.
No study has analysed how protein intake from early childhood to young adulthood relate to adult BMI in a single cohort.
No study has demonstrated non-inferiority of the subcutaneous route in comparison to other parenteral routes of administration.
No study has examined frailty in relation to mortality after femoral neck fractures in elderly patients.
No study has investigated all sensory properties simultaneously.
No study has tested the impact of EID upon running TT performance.
No study has yet examined whether anticipated HRQoL is stable over time.
No study has yet reported a protective cognitive effect of metformin , an insulin-sensitizing biguanide widely used in diabetic patients.
No study investigated the effects of parental lifespan on their progeny when offspring have T2DM.
No study made optimal use of theory as recommended in the TCS.
No study to date has examined the relationship between peripheral hearing and such an extensive array of cognitive measures.
No study was rated high quality , one was rated moderate quality , and five were rated low quality.
No subgroups were identified for retirement adjustment.
No substantial association between cognitive score and LDL , TG , and TC levels was found in either of the groups.
No substantial differences were found between the anterior , middle , and posterior parts of both structures.
No such associations were found in current workers.
No such associations were noted for Cd and VC.
No such associations were observed for HEI-2005 scores.
No such associations were observed for the brachial and femoral DCs , however.
No such associations were seen for either total physical activity levels or sedentary time.
No such association was observed for RA.
No such changes were observed for patients under other antipsychotics.
No such deprivation-related inequities were seen among men ( HII = @number@ [ @number@ ; @number@ ] ) .
No such difference was observed in the older adults.
No such difference was observed with the endocannabinoid or @number@ additional lipid species.
No such educational effort has yet been directed toward public health professionals.
No such effect occurred with regards to nonuniquely human emotions.
No such effects were found among women.
No such effects were seen for affective scores when adjusted for SCD.
No such improvements were observed when the homologous contralateral area was stimulated.
No such published data is available with regard to secondary care settings.
No such reduction in PrPC was seen in familial AD.
No such specific modulation was evident in old adults for the early N1 component but only at the later P3b component.
No such trends existed for MDD cohort.
No such whole-brain difference was detected for the 12-month scan interval ( n = @number@ ) .
No survival benefit for neoadjuvant treatment in patients over @number@ years was found , while women survived longer than men.
No survival differences were identified among women from distinct geographical regions.
NO synthase , type I ( NOS-I ) has been suggested to play a role in the etiology of Alzheimer's disease ( AD ) .
No systematic data exist to describe preferences for facial areas requiring treatment.
No systematic difference was found between low- and high-intensity exercises.
No systematic effects of the countermeasure were observed.
No systematic reviews on the effectiveness of multi-domain interventions exist in a well-defined frail population.
Notable among them are caspase-2 , @number@ and @number@
Notable differential transcriptome changes were also observed in alternative splicing patterns.
Notable improvements in facial rhytides , photodamage , acne scarring , and skin laxity have been reported.
Notable was the fact that e4 + showed a relative inability to recruit parietal regions as they aged.
Notably , A2M is known to dramatically decrease with age in humans.
Notably , accurate blood pressure measurements were performed on all the participants.
Notably , aged Treg exhibit decreased expression of the proapoptotic molecule Bim compared with Treg from young mice.
Notably , aging is an unfavorable factor for fibrosis regression and HCC development even after HCV eradication.
Notably , all these effects proved to be significantly restored by using PBA and TUDCA , known ER stress inhibitors.
Notably , a mask pack containing E-AP-SM2001 showed a > twofold more extensive moisturizing effect compared with one containing Saccharomycopsis ferment filtrate.
Notably , a number of studies have linked longevity nutrient sensing pathways in modulating circadian clocks.
Notably , apoA-I is the main component of these amyloids.
Notably , a significant number of individuals have persistent cardiac hypertrophy in the face of blood pressure that is normalized by drug treatment.
Notably , available evidence shows considerable variability in participants ' selection and assessment methods , rendering difficult direct comparisons.
Notably , blocking Prss29 activity was sufficient to rescue subfertility in Wt1 + / - mice indicating Prss29 as a critical factor in female fertility.
Notably , BMSC-specific inhibition of miR-188 by intra-bone marrow injection of aptamer-antagomiR-188 increased bone formation and decreased bone marrow fat accumulation in aged mice.
Notably , both MCT and AIT attenuated the extents of HE-induced coagulant factor VIII / fibrinogen elevations and aPTT shortening.
Notably , BZA combined with conjugated estrogens ( CE ) is a new menopausal treatment.
Notably , chloroquine considerably inhibited proteasomes in SK-N-SH cells and MEFs.
Notably , CMS dose-dependent sensitization to TRAIL was observed with TRAIL-insensitive cancer cells and confirmed in co-culture experiments.
Notably , CNV magnitude decreased parametrically with increasing acoustic detail in both age groups.
Notably , copper dyshomeostasis has been shown to underlie the pathophysiology of several neurodegenerative diseases including AD and PD.
Notably , cortical tissue from patients with Parkinson's disease-related synucleinopathy dementia with Lewy bodies showed less phosphorylation at Tyr125.
Notably , CSCs are usually resistant to chemo- and radiation therapies.
Notably , despite age-related changes in individual protein levels , protein co-expression modules were remarkably conserved across age groups , suggesting robust functional homeostasis.
Notably , despite better CVH , later-born individuals ( BASE-II ) reported lower self-rated health , presumably because of higher health expectations.
Notably , DGC bound directly to MKK4 and PI3K in an ATP-competitive manner.
Notably , does attention impact WM via its influences on early perceptual processing ?
Notably , ectopic expression of telomerase holoenzyme ( hTert ) can prevent replicative CS.
Notably , even livers in the elderly contained such marginal positive cells in the hilar region.
Notably , glycation of cortical bone from older donors led to much higher AGEs levels as compared to young donors.
Notably , however , IGF-1-treated SH-SY5Y cells still contained ubiquitinated protein aggregates.
Notably , human studies suggest a potential utility of 5-HT6 receptor antagonists in mild-to-moderate AD patients.
Notably , hypoxic inactivation of this SIRT1-AMPK pathway led to cisplatin and doxorubicin resistance.
Notably , IgM was found to associate with continuous NAB across cognitively normal control subjects.
Notably , inhibition of the ABAD-Aβ interaction significantly reduced mitochondrial Aβ accumulation.
Notably , in our investigations the ATP content of progeria fibroblasts was only approximately @percent@ of that found in healthy controls.
Notably , levels of the anti-inflammatory cytokine interleukin @number@ ( IL-10 ) were markedly elevated in monocytes from older subjects before and after vaccination.
Notably , lipid metabolic disturbances have been reported to be a risk factor for colorectal cancer.
Notably , Mdm2 overexpression promoted gains in one or more chromosomes with age , while it did not affect the rate of chromosome loss.
Notably , miR-21 was the most abundantly expressed miRNA in MCF-7 cells and overexpressed in TamR and LTED cells.
Notably , MK2-23 scFv DNA vaccines impaired the onset and growth of transplantable B16 melanoma cells not engineered to express HMW-MAA.
Notably , molecular events associated with metabolic disorders influence epigenetic regulation in chondrocytes , supporting the notion that OA is a metabolic disease.
Notably , most deletions removing a section of the D-loop are found in tumors.
Notably , no significant results were observed for the depressive scores and modulations of the EEG signal.
Notably , @number@ percent of edentulous older people with ID were without dentures.
Notably , p21 knockout in mice eliminated liver senescent stellate cells and alleviated liver fibrosis and collagen production.
Notably @percent@ of this long-stay NH population only told the nurses about their pain symptoms when asked directly.
Notably , PGE ( @number@ ) treatment increased the IGFBP5 protein level.
Notably , phosphorylation of Akt ( S473 ) and mobilization of [ Ca2 + ] i caused by fMLF was inhibited by compound @number@
Notably , Pin1 with Cys113 substituted by aspartic acid retains activity and is no longer sensitive to oxidation.
Notably , polypharmacy was also associated with higher rates of reduced gait speed and exhaustion.
Notably , pre- and post-intervention executive control was examined via the antisaccade task ( i.e. , eye movement mirror-symmetrical to a target ) .
Notably , recent proteomic analysis of brain samples from patients with mild cognitive impairment revealed that Pin1 is oxidized and also displays reduced activity.
Notably , RTH was positively correlated with white matter hyperintensities and positively correlated with symptom severity in the patient cohort.
Notably , SHS score was negatively correlated with RTL ( r = @number@ p < @number@ ) .
Notably , significant down- regulation of SPRED-1 protein , a validated miR-126-3p target , was found in senescent HUVECs.
Notably , some 5-HT6 receptor agonists seem to have promnesic and / or antiamnesic effects.
Notably , specific disruption of the TERB1-TRF1 interaction by a point mutation in the mouse Terb1 gene results in infertility only in males.
Notably , subclinical hypothyroidism ( SCH ) is one of the most important risk factors for dyslipidemia.
Notably , successful germline transgene transmission was confirmed in the second-generation offspring derived from the symptomatic transgenic marmoset gamete.
Notably , such improvements occur without changes in Aβ and tau pathology , and instead are linked to an increased level of brain-derived neurotrophic factor.
Notably , telomerase activity is affected in a gene dose-dependent manner when comparing heterozygote RMRP carriers with patients with CHH.
Notably , the ability of estradiol to improve cognition declines with advanced age along with decreased expression of estrogen receptors.
Notably , the ability to induce senescence is lost in a mutant version of p33ING1 present in human tumors.
Notably , the accumulation of iron-ferritin bodies was accompanied by signs of oxidative damage.
Notably , the amplitude and latency of the ERN and Pe did not differ significantly between the age groups.
Notably , the anterior VFT-related SMA response was more robust in the younger than in the elder group.
Notably , the Chemerin receptor CCRL2 is remarkably upregulated in cSCC cell lines and human patient biopsies.
Notably , the common principle of these studies was the proactive maintenance of stable , long-term homeostasis of the entire organism.
Notably , the depletion of either YAP or PML partially impairs the induction of senescence following WRN loss.
Notably , the first electron microscopy structures of telomerase were reported , of the Tetrahymena thermophila telomerase holoenzyme and a human telomerase dimer.
Notably , the first human skin gene expression study of resveratrol was not published until @number@
Notably , the FMRP-Top3β interaction is abolished by a disease-associated mutation of FMRP , suggesting that Top3β may contribute to the pathogenesis of mental disorders.
Notably , the gene correction efficiency was over @percent@ in these embryos by base editor.
Notably , the gradual decrease in basal autophagy coincided with replicative senescence induction.
Notably , the proportion of CD4 + MAIT cells increased with age , whereas that of CD8 + MAIT cells decreased with age.
Notably , there is fine-tuned crosstalk between AHR and NRF2 , which mutually increase or decrease their activation states.
Notably , these associations showed specificity to sphingomyelin acyl-chain length and saturation.
Notably , they do not fit mortality rates at young and old ages.
Notably , they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy.
Notably , this blockage is exacerbated in Cockayne Syndrome and xeroderma pigmentosum patient-derived lymphoblastoid and fibroblast cells.
Notably , this has been the situation for the past decade.
Notably , this receptor switch induces a 10-fold decrease in sensitivity to BRAF inhibitors.
Notably , those CpGs that revealed significant association with life expectancy were overall rather hypomethylated upon aging.
Notably , to evaluate scar severity , the Japan Scar Workshop ( JSW ) has established the JSW Scar Scale.
Notably , understanding the underlying mechanisms of AD made it possible to begin the development of new and potentially effective therapeutics.
Notably , USPCB is widely used to retrieve tissue specimens in cases of hepatic lesions.
Notably , Wii based biofeedback exercise was perceived by the older adults as a highly motivating type of training.
Notably , with progressive age the incidence of cardiac arrhythmias , myofibrillar disorganization and susceptibility to heart dysfunction and failure all increase significantly.
Not all analyzed drugs activate the PGC pathway or alter mitochondrial protein levels.
Not all people benefit from intensive glycemic control.
Not all senior citizens , however , encounter problems with new media.
Not all technologies are suitable for all mitral anatomies and regurgitation mechanisms.
Not all the predictive variables for the ANU-ADRI were available in the PATH project.
Not all women with rSUI chose surgical retreatment.
Not a lot is known about the quality of life of nursing home residents in Hong Kong.
Not any biological adverse effects was measured.
No targeted therapy is available against this subtype of cancer owing to a lack of validated molecular targets.
Not being a first-born and having more between-meal snacks were associated with increased caries risk.
Not by a long shot.
Notch genes are involved in embryogenesis , nervous system , and cardiovascular and endocrine function.
Notch signaling is a master controller of the neural stem cell and neural development maintaining a significant role in the normal brain function.
Not considering the time in follow-up may be overestimating the effect of MCAs.
No technique is ideal in every patient.
Noteworthy chronic nutritional activation of mTOR signaling has been implicated in the development of beta cell mass expansion and on insulin resistance.
No therapy exists to slow down or prevent Parkinson's disease ( PD ) , a debilitating neurodegenerative disorder.
Nothing is known regarding the long-term effects of CR on glucose tolerance and insulin action in lean healthy humans.
Nothing is known regarding the long-term effects of CR with adequate intake of vitamin and minerals on bone quantity and quality in middle-aged lean individuals.
Noticeably , CK2 activity was downregulated in chondrocytes with advancing age.
Notions of traditional masculinity preclude some husbands from providing emotion work even when their wife is health-impaired.
Not meeting physical activity guidelines was associated with reduced life expectancy that is larger among non-overweight individuals than among overweight / obese.
Not meeting relative MVPA and VPA recommendation was associated with significantly higher likelihood for presence of MetS.
Not much is known about the differential role of mechanic and pragmatic cognitive functions when moderating reduced technology ownership in old age.
Not much is known yet about how migrant families adapt their family cultures to the host cultural context.
Notochordal cells were still present in the IVDs of adult NCD but were not seen in the CD breeds or in humans.
No tolerability issues were reported.
Not only age-related changes of the organism contribute in the development of this pathology , but also harmful habits.
Not only can CoRAL distinguish between RNA classes with high accuracy , but it also uses features that are relevant to small RNA biogenesis pathways.
Not only challenges , but also the opportunities that old age provides for charting the spiritual journey have underpinned this model.
Not only could it shed light on disease pathogenesis , but it may also provide potential targets for effective treatment , screening , and prevention.
Not only fibroblasts but also induced pluripotent stem cells ( iPSCs ) and neural rosettes from the same origins showed similar expression patterns.
Not only hepatocytes but Kupffer cells ( KCs ) and dendritic cells ( DCs ) are of importance in this instance.
Not only is there minimal recovery but also a high level of safety with aesthetic RF treatments.
Not only is this an invaluable tool for conducting large-scale RNAi or compound screenings , but also allows rapid validation of candidates of interest.
Not only sUV-induced MMP-1 expression , but also sUV-induced signaling pathway activation were decreased in PKCα knockdown cells.
No tonometry method was dependant on CCT or CC.
No total @number@ óbitos ( @percent@ ) foram relacionados à imunodeficiência após aplicar o CoDe.
No toxicity was observed in the in vivo and ex vivo experiments.
No transfer effects were observed.
No transient or permanent post-inflammatory hyperpigmentation ( PIH ) ; or serious adverse events were reported.
No treatment-related adverse events occurred.
No trials assessed clinical or carriage outcomes.
No trials were identified following contact with anti-aging and cosmetic organizations , companies and professional bodies.
Not surprisingly , excess deaths during heat waves @number@ ) occur predominantly in older individuals and @number@ ) are overwhelmingly cardiovascular in origin.
Not surprisingly , identifying drugs and compounds that extend lifespan in model organisms is a growing research area.
Not surprisingly , interest in stem cell research has never been greater among members of the public , politicians , and scientists.
Not surprisingly , nursing home residents most commonly expected nursing care ( @percent@ ) but @percent@ preferred care provided by family or friends and neighbors.
No tumor cells had obvious intracytoplasmic zymogen granules.
Not unexpectedly , not only the results of these operations , but also the associated morbidities , are similar in older and younger populations.
Not unlike the general population , the population of nurses is aging.
Notwithstanding , no correlation was found between telomerase activity and subtypes of RCC.
Notwithstanding , no studies have as yet investigated the effects of resistance training on metabolic syndrome in postmenopausal women.
Notwithstanding the limitations of case-control designs , our data suggest that the ApoE might be a candidate to influence EL.
Notwithstanding the potential benefits , AFC influence on mainstream actions of government has been limited by uncertain political commitment and growing fiscal austerity.
No type of AF had an independent association with mortality in patients without CKD.
No unexpected adverse effects were detected or reported throughout the independent treatment.
No unexpected adverse effects were reported.
No unexpected adverse events were reported.
Nous analysons les articles traitant du sujet pour démontrer l'hétérogénéité des symptômes au moment de la première consultation et ceci dans tous les groupes d'âge.
No UV-induced erythema was observed at the black and green tea gel sites in any of the subjects.
No variability in survival was noted after non-VF arrests ( p > 0.05 ) .
No variables capable of predicting the response to treatment were detected.
No variables entered the model for change in PWT.
No variables tested interact with age to moderate decline.
No variants in the TMEM230 region were found associated with PD , age at onset , or cerebrospinal fluid α-synuclein levels.
No variant was identified to be associated with AD in either case-control sample.
No variation for Tie2 , Ang1 , or Ang2 expression was observed among the studied groups.
No vascularization-related flap problems were noted.
No vaspin variations were observed in either group.
Novel amine N-halamine copolymerized polystyrene ( ANHCPS ) nanostructures were controllably fabricated as potent antibiotics by using the surfactant-free emulsion copolymerization for killing pathogenic bacteria.
Novel analytical approaches are also being developed to facilitate the translation of findings from the research to the clinical setting.
Novel antibacterial monomer dimethylaminohexadecyl methacrylate ( DMAHDM ) was synthesized and incorporated into Transbond XT at @number@ @number@ and @percent@ by mass.
Novel approaches such as vaccinations are currently under vigorous investigation , but still far from translation into clinical practice.
Novel BDNF-focused interventions are being developed for obesity , diabetes , and neurological disorders.
Novel biomarkers are needed to better profile progressive neurodegeneration in PD.
Novel biomarkers are urgently needed to assist in managing these diseases.
Novel BTX-A preparations may offer advantages over existing products in terms of handling and immunogenicity.
Novel candidate mutations and variations were confirmed by direct sequencing in @number@ HCs.
Novel compliant floors aim to decrease the risk for fall-related injury by providing substantial force attenuation during the impact phase of falls.
Novel features of this system include its glycan-modifying enzymatic function in the urinary lumen on calcium and phosphate transporters.
Novel finding is the postmenopausal HRT-reduced miRs-182 , miR-223 and miR-142-3p expression in female skeletal muscle.
Novel findings of this study are that propofol anaesthesia resulted in higher ST than thiopentone and concomitant treatment with lithium treatment lowered ST.
Novel innovative models are urgently needed.
Novel intraoperative measurement techniques and three-dimensional analysis of the spine may allow for vastly improved operative correction.
Novel long-acting factor proteins are being licensed to extend FVIII and FIX half-life , thereby reducing infusion frequency and potentially bleed frequency and associated morbidity.
Novel methods of photoprotection are being targeted as additional measures , with growing interest in the potential for systemic photoprotection through naturally sourced nutrients.
Novel neuroimaging techniques suggest that functional networks are diminished in bvFTD that might be relevant to empathy and social behavior.
Novel pharmacological approaches might be effective in targeting this pathophysiological feature , thus improving the clinical outcomes.
Novel potential hub genes relevant for these processes were successfully identified.
Novel strategies for activation of the UPS by genetic manipulation and treatment with synthetic compounds have also recently been identified.
Novel therapeutic strategies aimed at preventing or reversing these immunologic defects may be necessary if HIV-infected patients are to achieve normal life span.
Novel therapeutic targets that address the pathophysiology of this disease are under consideration , although there are no proven therapies for DHF to date.
Novel therapies that can protect and / or restore muscle function during aging would have profound effects on the quality of life for this population.
Novelty emerged when student samples evaluated the meaning of @number@ emotion terms on @number@ emotion features.
Novelty interventions are characterized by a high task variability but do not target specific processing demands affected in aging and dementia.
Novelty P3 amplitude increased with increasing task difficulty in both age groups , but the effect was more robust in younger listeners.
Novelty processing , as indexed by novelty P3 amplitude , was similar between the groups.
Novelty robustly emerged as the fourth dimension.
Novice 8-9-year old children ( n = @number@ ) and 11-12-year-old children ( n = @number@ ) practiced a golf putting task.
Nowadays cataract is more than a routinely recognized and almost always successfully operated ophthalmologic disease.
Nowadays , in countries with developed health care systems , more than @number@ percent of newborns with SCD survive into adulthood.
Nowadays , individuals with hemophilia enjoy a life expectancy at birth close to that of males in the general population.
Nowadays , it is well established that OT plays an important role in the control of bone and fat mass and their metabolism.
Nowadays most of malignancies requiring surgical treatment are diagnosed in old population.
Nowadays , sirtuins have become famous molecules for slowing aging and decreasing age-related disorders.
Nowadays , the ovarian reserve ( OR ) is considered more important than chronological age to estimate female reproductive capability.
Nowadays , there are @number@ vaccines available for adults.
Now , after @number@ years of JRS foundation , only one in four members of JRS may join to JSTB.
Now , clinical studies on elderly esophageal cancer must be improved.
Now dermatologists can feel confident confirming that it prevents photoaging in middle aged adults as well.
No weekend effect on discharge clinical outcome was seen in teaching hospitals.
Now , Miller et al.
Now more than ever , physicians must be particularly vigilant in checking for the non-oncological late effects of DES.
Now , @number@ years after the start of Medicare Part D , several changes have been made to the program's design.
No worsening of ED , glucose , HbA1c , ALT , AST , AMS were observed in men treated with tamsulosin.
Now , we make an overview on the correlative researches in the field.
NOX5-L depletion consistently suppressed cell proliferation , invasion , and migration in vitro.
NOX-dependent ROS signaling pathways can also be self-regulating , with molecular redox sensors that limit the local production of ROS required for effective signaling.
NPD1 reduces Aβ42 peptide release from aging human brain cells and is severely depleted in Alzheimer's disease ( AD ) brain.
NPI domain scores after the initial open-treatment phase were not associated with relapse.
NPM mRNA destabilization involves the association of HuR with the decay factor KSRP as well as the ribonuclease PARN and the exosome.
NP responsiveness did not predict ∆ADP.
NPs can contribute to improving the quality of life for older adults and reducing adverse consequences by understanding OH and adequately managing it.
NPs can provide therapeutic options to improve vaginal health and quality of life.
NPS data was gathered from caretakers / family members using the Neuropsychiatric Inventory.
NPS ratings might be confounded by cultural beliefs , sometimes leading caregiver to interpret symptoms as part of \ "normal \ " aging.
NP test performance did not correlate with the number of SSR among HIV-negative participants.
NP tests assessed multiple domains ( memory , psychomotor speed , and executive functioning ) .
NP was similar for both groups.
NPY ( @number@ nM ) stimulated the proliferation of all bone marrow cells age groups , and their proliferation was blocked by Y5R antagonist.
NQO1 binds STUB1 via the Hsc70-interacting domain ( tetratricopeptide repeat domain ) and undergoes ubiquitination and degradation.
NQO1 is a FAD containing NAD ( P ) H-dependent oxidoreductase that catalyzes the reduction of quinones and related substrates.
NR4A subfamily members are aberrantly expressed in inflamed human synovial tissue , psoriatic skin , atherosclerotic lesions , lung and colorectal cancer cells.
Nrf1 knockout resulted in the increased expression of GCLC and GCLM in human bronchial epithelial ( HBE1 ) cells.
NRF2 accumulation leads to widespread misregulation of gene expression and an imbalance in cytosolic redox balance.
Nrf2 activates nearly @number@ cytoprotective target genes.
NRF2 immunoreactivity was mainly detected in the nucleus of the breast carcinoma cells and it was positive in @percent@ of the cases.
Nrf2 is a master transcription factor that regulates antioxidative and detoxification enzyme genes.
Nrf2 is emerging as a key neuroprotective protein in neurodegenerative diseases , since it helps neuronal cells to cope with toxic insults and OS.
Nrf2 knockdown enhanced the increase in C3a and C3b from CSE , but not iC3b , C5a , or C5b-9.
Nrf2 levels and activity are tightly regulated , and three subcellular populations of the transcription factor have been identified.
Nrf2 levels have been shown to decrease with aging and silencing Nrf2 gene induces premature senescence.
NRI was larger in women below age @number@ years ( up to @number@ for hip fracture ) .
NSAIDs and / or aspirin use are associated with complications from both the upper and the lower gastrointestinal tract.
NSAIDs are often given elderly persons , and aging is a risk factor of the development of NSAID-related ulcer.
NSAIDs are widely used in the treatment of inflammatory diseases as well as of tendon diseases associated with pain in sports and labor.
NSAIDs can be an effective treatment option for many older persons but caution should be exercised in this often fragile population.
NS expression reflects the cell's proliferation state indicating that the cell is active in the cell cycle , whereas NS signals disappear upon differentiation.
NT219 treatment promotes stress resistance and protects nematodes from AD- and HD-associated proteotoxicity without affecting lifespan.
NTCP modeling by multivariate logistic regression analysis using bootstrapping was performed.
NTD might be used as a biomarker to guide acute clinical care and identify infants at risk for acute and chronic morbidity.
NT @number@ is a BTX-A preparation that is free from complexing proteins and is in the advanced stages of aesthetic development.
NT : p < 0.001 ; HT : p < 0.01 ) .
NT-proBNP and the SHFS showed similar predictive capacities ( @number@ versus @number@ P = 0.105 ) .
NT-proBNP is an excellent predictor of adverse events in patients with diabetes mellitus.
NT-proBNP levels were measured at visits @number@ @number@ and @number@
NT-proBNP , renal function , lipid status and other demographic variables were measured at baseline.
NT-proBNP was bound with the SHFS ( r = 0.500 , P < 0.001 ) .
NT-proBNP was negatively correlated with GFR as evaluated with all the different formulae ( r @number@ to @number@ all p < @number@ ) .
NTx , a urinary marker of bone resorption did not change during the study and was not affected by the silicon water supplementation.
NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition.
Nuclear CLU , a truncated CLU formed by alternative splicing , is responsible for promoting apoptosis via a Bax-dependent pathway.
Nuclear DNA damage foci were detected in the endothelium of ex vivo corneas by immunostaining for H2AX-Ser139.
Nuclear dysmorphy was not significantly improved when transfected cells were treated with drugs disrupting microtubules or actin filaments or modifying the global histone acetylation pattern.
Nuclear exclusion renders RagC incapable of gaining the GDP-bound state necessary to stimulate mTORC1.
Nuclear factor-κB ( NF-κB ) regulates cellular responses to inflammation and aging , and alterations in NF-κB signaling underlie the pathogenesis of multiple human diseases.
Nuclear intermediate filament networks formed by A- and B-type lamins are major components of the nucleoskeleton.
Nuclear lamins support the nuclear envelope and provide anchorage sites for chromatin.
Nuclear lamins were originally described as the main constituents of the nuclear lamina , a filamentous meshwork closely associated with the inner nuclear membrane.
Nuclear localization of these transcription factors in differentiated NPCs was observed following exposure to IL-1α and TNF-α.
Nuclear medicine has an important role in the care of newborns and children less than @number@ y old.
Nuclear pore complexes ( NPCs ) , are large multiprotein channels that penetrate the nuclear envelope connecting the nucleus to the cytoplasm.
Nuclear receptors act as ligand-dependent transcription regulators and play key roles in the regulation of body lipid metabolism and the development of many cancers.
Nuclear transfer experiments in a mouse model of reproductive aging show that the reproductive aging phenotype segregates with the nucleus rather than the cytoplasm.
Nuclei are virtually devoid of ANS binding sites.
Nucleic acid oxidation peaked early in disease progression and remained elevated.
Nuclei of these chondrocytes appeared lobulated or indented.
Nucleocytoplasmic ratio of the LH cells gradually decreased and became significant after the age of @number@
Nucleolar stress can be triggered by genetic and epigenetic factors , and by specific signaling mechanisms , that are altered in neurodegenerative disorders.
Nucleolin is a multifunctional protein localized primarily in the nucleolus , but also found in the nucleoplasm , cytoplasm and cell membrane.
Nucleolin's implication in disease is linked to its ability to associate with target RNAs via its four RNA-binding domains and its arginine / glycin-rich domain.
Nucleopathies belong to a group of rare diseases , associated with nuclear protein abnormalities.
Nucleopathies from both groups may be ranked in terms of age of first symptoms and the disease severity.
Nucleostemin ( NS ) is a nucleolar protein expressed in stem and cancer cells.
Nucleostemin ( NS ) is a nucleolar protein regulating stem cell proliferation and pluripotency.
Nulliparity and obesity decrease breast cancer risk in younger women , but increase risk in older women.
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@number@ ; 16 ( @number@ ) : 154-161. < / em > < / p > .
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@number@.9 ( @number@ ) ] , CFU-ECs [ Median ( IQR ) : @date@ ( @number@ ) , @date@ ( @number@ ) , iii.
@number@.9 ( @number@ ) , iv.
( @number@ ) A comparison of biomarkers among aging groups : there were significant differences in PP among @number@ aging groups in @number@ age groups.
( @number@ ) activation increases cytosolic Ca2 + , activates cell-specific eNOS or nNOS.
( @number@ ) All children should receive measles vaccine.
@number@ % AMD subjects in our study had visual impairment with 6 / 246 / 60 vision and @percent@ had vision < 3 / 60-PL.
@number@ ) , a measure tapping psychological aspects of medical interventions , would predict scan outcome when current diagnoses of claustrophobia were controlled.
( @number@ ) ; Am J Med Genet Part A 143A : 1421-1430 ] with the diagnosis of neonatal progeroid syndrome ( NPS ) .
@number@'-AMP-activated protein kinase ( AMPK ) is a pivotal energy sensor that alleviates or delays the process of fibrogenesis.
( @number@ \ "Analytical Description of Growth , \ " J. Theor.
@number@ ) and an average number of missing teeth of @number@ ( s.d.
( @number@ ) and Grima et al.
@number@ ) and in typically developing children ( Exp.
@number@ ) and selected the best strategy on each problem less frequently ( Expt.
@number@ ) and severity ( p < 0.
@number@ ) and spacing ( Exp.
( @number@ ) and the results reported by Bell and Jones.
( @number@ ) A-N : reverse of N-A.
( @number@ ) Asphyxiating gases , irritant gases and organic solvents are the main chemicals which caused these poisoning accidents.
( @number@ ) , as SE is equated with its predictor ( s ) .
@number@ ) As the speech rate increased faster , speech perception scores decreased.
( @number@ A theoretical study of the effect of intraventricular pulsations on the pathogenesis of hydrocephalus.
( @number@ ) Avoid prescribing antibiotics for uncomplicated upper respiratory tract infections.
@number@ ) BMI of the residents living in the rural areas is lower compeard to the residents living in the citie.
( @number@ ) Both photopic a-wave and b-wave amplitudes and implicit times were increased at high stimulus strengths.
@number@ cases ( @percent@ ) had an aneurysm in the anterior circulation.
@number@ cases ( @percent@ ) had smoking history.
@number@ cases received clipping , @number@ cases coil embolization and @number@ cases treated conservatively.
@number@ cases with ubiquitin positive structures were found.
( @number@ ) Change in cellular phenotype.
( @number@ ) Changes in intracellular signaling functions.
( @number@ ) Changes in responsiveness to contracting and relaxing mediators.
@number@ children with DCD aged @number@ to @number@ years ( @number@ in each age group ) and @number@ TD children participated in the study.
@number@ Chinese adults ( @number@ men and @number@ women ) aged 60-88 were recruited.
( @number@ cm / s ) higher PWV was associated with @number@ ( s.e.
@number@ cognitively healthy elderly controls were also included.
@number@ ) Communication is essential.
@number@ community-dwelling older adults of at least @number@ years in age volunteered to participate.
@number@ community-dwelling older adults took part in this study.
@number@ conditionally healthy people aged 40-79 years were examined.
@number@ consecutive individuals who were ≥50 years of age and who underwent initial / follow-up MRI evaluations within an interval of 34-45 months were included.
@number@ consecutive stroke- and dementia-free older adults ( @percent@ men , ages @number@ ± @number@ years ) .
( @number@ ) Consistent trail foot placement before the obstacle across all ages allowed space and time for the trail foot to clear the obstacle.
( @number@ ) could have produced misleading results.
@number@ CpG sites were more than @percent@ differentially methylated in fibroblasts upon aging.
( @number@ ) Critically ill patients with signs of infection need early appropriate antibiotic therapy.
( @number@ % ) , Cunninghamella bertholletiae ( @number@ % ) and unspecified ( @number@ % ) .
@number@ ) DAPI is a reliable marker for RFs and can be used with immunolabeling.
( @number@ ) Dark adaptation time was delayed for pure rod and L / M cone-driven responses , respectively.
( @number@ ) Dark-adapted a- and b-waves implicit times were prolonged : there was a direct proportional correlation between minimal a-wave implicit times and age.
( @number@ ) Dark-adapted a-wave but not b-wave amplitudes were reduced , yielding higher B / A ratios.
@number@ @date@ ) .
@number@ deaths of which @number@ cardiovascular disease-related were recorded over a mean follow-up time of @number@ years.
@number@ deaths ( @percent@ ) occurred over @number@ years.
@number@ deaths were recorded during follow-up.
( @number@ ) demonstrated that hierarchical age-period-cohort ( HAPC ) models perform well when basic assumptions are satisfied.
( @number@ ) describe defects in the nuclear pore complex and impaired nucleocytoplasmic transport in Huntington's disease ( HD ) .
@number@ % described the psychological / mental aspect of the disease.
( @number@ ) describe that dietary caffeine inhibits the NLRC4 inflammasome , which is associated with disease-free aging.
@number@ ) did not suggest an association.
@number@ differentially methylated regions ( DMRs ) were observed between both groups.
( @number@ ) Do not prolong prophylactic administration of antibiotics in patients after they have left the operating room.
( @number@ ) Do not treat an elevated C-reactive protein ( CRP ) or procalcitonin with antibiotics for patients without signs of infection.
( @number@ ) Do not treat asymptomatic bacteriuria with antibiotics.
( @number@ ) Do not treat Candida detected in respiratory or gastrointestinal tract specimens.
( @number@ ) Do the people understand the paradigm shift ?
@number@ Early horn growth was positively correlated with body mass in pre-reproductive females and with reproduction in very young and senescent adults.
@number@ elderly aging over @number@ years with both genders had been interviewed from April to June of @number@
@number@ elderly patients were retrospectively evaluated and included in the study.
@number@ elderly people of both sexes ( @number@ men , @number@ women ; M age = @number@ yr. , SD = @number@ ) participated.
@number@ elderly people with a mean age of @number@ , 5±1 , 7 years were surveyed.
@number@ eligible sites covering @number@ countries were evaluated.
( @number@ ) elucidate a molecular mechanism whereby DNA-PK negatively regulates AMPK , contributing to metabolic and fitness decline during aging.
( @number@ ) Emotional changes included greater acceptance of resting , sharing of personal stories and feelings , and positive attitude toward exercise.
( @number@ ) Endothelial cell senescence.
@number@ entropions were recurrencies , one surgery was performed after ectropion.
@number@ Environmental conditions during early development can affect the growth patterns of vertebrates , influencing future survival and reproduction.
( @number@ ) ET3 binds to ETBR on both sides of intercellular space.
@number@ examinees in total , aged from @number@ to @number@ were included in the research.
( @number@ ) F-AV-133 PET also showed additional information in substantia nigra integrity in PD subjects by voxelwise analysis.
( @number@ ) F-FDG enabled to visualize liver metastasis as clear positive image that could not be obtained by conventional nuclear imaging.
( @number@ ) F-FDG was first applied for imaging of animal tumors in @number@ and for brain tumor imaging clinically in @number@
( @number@ ) F-fluorodeoxyglucose positron emission tomography was used to measure regional cortical metabolism.
@number@ had at least @number@ biomarker measurement available prior to HIV infection and after ART initiation with evidence of viral suppression.
( @number@ ) have recently demonstrated that behavioral grating orientation discrimination correlates with GABA ( gamma aminobutyric acid ) concentration in human visual cortex.
( @number@ ) Head angle was progressively lower with advancing age , an apparent attempt to gather more visual information during approach.
@number@ healthy controls were included for comparison.
@number@ healthy men and women received dexamethasone ( 2mg ) the day before , and propranolol ( 80mg ) one hour before psychosocial stress induction.
@number@ healthy volunteers , aging from @number@ to @number@ years ( average @number@ ) were recruited.
@number@ healthy volunteers were recruited from a screening study.
@number@ HF patients completed a neuropsychological battery at baseline , 3-months and 12-months.
@number@ HIV-infected patients were included in both treated and untreated groups , but sampled at different timepoints.
( @number@ ) H-N : reverse of N-H.
@number@ Hz short tone burst was employed for examinations.
( @number@ ) Impaired angiogenesis.
@number@ ) implicated in neuronal development , brain maturation , and neuroplasticity ( Brandon and Sawa @number@ Chubb et al.
@number@ in Beijing Tiantan Hospital.
@number@ incidents of ALS were registered.
( @number@ ) In contrast to conventional ASL , which was substantially affected by brain atrophy , ts-ASL was virtually independent of it.
@number@ individuals completed a NeuroTrax computerized cognitive assessment at ages 48-52.
@number@ individuals ( mean / range : 15 / 4-29 years ; @number@ females ) were included.
@number@ individuals ( @percent@ women ) , recruited in @date@ during the Swedish National March and followed through record-linkages for @number@ years.
@number@ individuals performed five trials of self-paced , non-cued gait initiation on an instrumented walkway.
@number@ individuals suffering from Down syndrome ( DS ) were enrolled in this study as group of pathological participants.
@number@ individuals were APOEε4 carriers and @number@ were non-carriers.
@number@ individuals who underwent screening colonoscopy in @number@ in Bavaria , Germany , and who were not diagnosed with CRC were included.
( @number@ ) In Europe and some other countries , sunscreens are regulated as cosmetics , not as drugs.
( @number@ ) in Human Molecular Genetics reports the largest genome-wide association study of human longevity to date.
( @number@ ) Introduction of the novel technique of combining CFSE and BrdU staining to do so.
@number@ invasive CRC were detected.
@number@ items have been adapted and further validated by @number@ nurses.
( @number@ ) It increases survival time of neuron in culture.
( @number@ ) It maintains the nonproliferative state of cultured senescent human fibroblasts and prevents cell death induced by telomere dysfunction.
@number@ IU / cell , unadjusted p = @number@ adjusted p = @number@ ) .
( @number@ J Appl Physiol , 20 : 1179-1186 ) .
( @number@ ) J Pharmacol Exp Ther 318 : 238-245 ) .
@number@ kb / genome , p = @number@ ) were markedly lower in PCAD patients compared to controls.
@number@ Lebanese women ( @number@ obese , @number@ overweight and @number@ normal weight ) aged from @number@ to @number@ years old participated in this study.
@number@ Le Bozec and Maton @number@ ) .
@number@ ) Left-right axial rotation negatively correlated to the age of the patient ( r = @number@ p = @number@ ) .
@number@ ) Left-right axial rotation within the atlantoaxial joint was measured to be 17° ( mean value ) following implant removal.
( @number@ % ) , Lichtheimia spp.
@number@ liquidators who had worked in the Chernobyl accident area were examined.
( @number@ ) Low-grade pro-inflammatory environment.
@number@ male AUD patients and @number@ matched healthy controls were examined.
@number@ male ironman athletes ( age : 35±1 yrs.
@number@ , ( MDMA ; ecstasy ) is a popular party drug known to cause selective serotonergic damage.
@number@ measurements were done for @number@ knees MRI.
@number@ medical doctors ) .
( @number@ ) Memory loss was the first identified cause of self-care neglect leading to caregiver intervention.
@number@ men and @number@ women of the average age @number@ + / - @number@ y. ( range 35-93 y. ) were out of this number.
@number@ men , mean age @number@ years ( standard deviation @number@ ) were included in the analysis.
@number@ menopausal women aged @number@ to @number@ years and @number@ reproductive women aged @number@ to @number@ years were studied.
@number@ men , showing a greater precocity and earlier decline in women.
@number@ meta-analyses demonstrated that higher adherence to the Mediterranean diet reduced the risk of future diabetes by 19-23%.
@number@ Millar et al.
@number@ ml blood sample of each subject was collected , and the Measles IgG antibody was measured by ELISA assay.
@number@ mm ) ) and confirms that mammalian lenses scale with size.
@number@ mm for thickness ) and decreasing again along the lower lumbar vertebrae ( both by @number@ mm ) .
@number@ mm indicated severe pain.
@number@ mm ) ; mouse ( approx.
( @number@ m ( @number@ ) ) ( @number@ ) , P = @number@ ] .
( @number@ m ( @number@ ) ) ( @number@ ) ] vs ( @number@ ± @number@ ) ml.min.
@number@ ) Models are needed to test efficacy of drugs and to uncover potential side effects of senolytic agents.
( @number@ ) Most of the cases come from the chemical industry and light industry .
( @number@ ) Most of them are from the south of Jiangsu and coastal areas.
@number@ ) m / s slower gait speed at baseline and throughout the study period ( P < @number@ ) .
( @number@ % ) , Mucor spp.
@number@ N ) .
( @number@ ) N-A : a neutral face that suddenly changed to an angry face.
@number@ National Institute on Aging and WHO @number@ Yach et al.
@number@ natural water samples were collected from the public papers.
@number@ N ) , compared to the native screws ( Median @number@ ± @number@ N , Min.
[ @number@ ] : Neurobiol Aging 30 : 717-730 ) .
( @number@ ) ; Neurobiol Aging 31 : 765-771 ] .
( @number@ ) ; Neurosci Lett 440 : 340-343 ] as well as reduced telomere probe light intensity values in interphases [ Jenkins et al.
@number@ new esophageal cancers being currently diagnosed annually.
@number@ new peptide preparations revealing geroprotective properties are submitted to the Russian Health Ministry to be registered as drugs.
@number@ N , Max.
@number@ N , Max.
@number@ nm , P = @number@ mW ) to treat the young 2BS cells.
( @number@ ) NO modulates diverse cell-specific functions by NO / cGMP pathway , controlling transcriptional factors , or other mechanisms.
@number@ normal-hearing listeners between @number@ and @number@ years of age participated in the study.
@number@ normal subjects and @number@ BRVO patients were studied.
@number@ [ @number@.2-4.4 ] ) , and lower alpha power and peak frequency ( HR [ @percent@ CI ] = @number@ [ @number@.3-1.0 ] resp.
@number@ [ @number@.4-1.0 ] ) were associated with clinical progression over time.
@number@ ( @number@ ) 688-694 ] .
@number@ @number@ age-matched subjects without IBS were selected as comparison cohort.
@number@ @number@ and @number@ ) and Shandong Provincial Natural Science Foundation , China ( ZR2013HQ002 , ZR2014HQ068 ) .
@number@ @number@ men and women aged @number@ years and older participating the Rotterdam study.
@number@ ( @number@ ) @number@ and Osborne et al.'s , J. Forensic Sci.
@number@ ( @number@ ) @number@ ) , Buckberry and Chamberlain's , Am.
@number@ ( @number@ ) @number@ İşcan et al.'s , J. Forensic Sci.
@number@ ( @number@ ) @number@ method of aging the auricular surface of the ilium , İşcan et al.'s , J. Forensic Sci.
@number@ ( @number@ ) @number@ method of aging the sternal end of the fourth rib , and Meindl and Lovejoy's , Am.
@number@ ( @number@ ) @number@ methods for aging both lateral-anterior and vault sutures on the cranium.
@number@ ( @number@ ) @number@ revisions of the Lovejoy et al. , Am.
@number@ ( @number@ % ) of those fulfilled the present AHA criteria.
@number@ ( @number@ % ) residents were in dependent status.
@number@ ± @number@ years , @percent@ men , @percent@ black ) .
Number of ADL impairments , cognitive measures , pre-admission illnesses and illness severity were derived from the MDS.
Number of chronic conditions and caregiver-reported relationship strain are potential targets of intervention during discharge process.
Number of depressive symptoms was assessed with the EURO-D scale.
Number of FRIDs and to a lesser extent total number of medicines at discharge were associated with recurrent falls.
Number of hospitalizations , institutional outpatient visits , and physician visits were estimated with a negative binomial regression.
Number of intervention categories was compared with primary outcomes.
Number of medications on discharge was also associated with recurrent falls [ OR @number@ ( @number@.0-1.3 ) ] , but DDIs were not.
@number@ of @number@ children ( @percent@ ) had a high signal on SPAIR with a corresponding low signal on T1 in at least one bone.
@number@ of @number@ converted in the law no.
@number@ % of patients were extremely satisfied , @number@ % were satisfied , and only @number@ % were unsatisfied.
Number of perseverations was higher in individuals with AD as compared with OAs.
Number of residents with diabetes increased from @percent@ in the year @number@ to @percent@ in @number@ ( p≤0 , 001 ) .
Number of sclerotic glomeruli increases during the aging process.
Number of teeth missing was obtained from self-reporting questionnaire and confirmed by trained interviewers.
@number@ % of the hypertensive subjects and @number@ % of the normotensive subjects showed eutrophic remodeling , while hypertrophic remodeling was not detectable.
@number@ of them participated in the prospective cohort study conducted in the city of Pune , India.
@number@ of these retested in replicate studies verified differential expression between AD and controls.
Number of ton- , lifting- and kneeling-years showed an exposure-response association with increased risk of LTSA ( P < 0.0001 ) .
@number@ ) of UEI.
Number of visits increased in winter season compared with the other seasons.
@number@ old adults ( two experimental groups each n = 13 and a control group , n = 12 ) participated in the study.
@number@ older adults received @number@ weeks ( @number@ sessions ) of imagery cognitive bias modification or a control condition.
@number@ older drivers ( M = 71.44 years ) returned repeatedly completing a ride either with or without a support system in a driving simulator.
@number@ older individuals ( aged 60-92 years ) were recruited from outpatient clinics and elderly homes.
@number@ ) or that were removed prior to target presentation ( Exp.
@number@ ) or within- ( Exp.
@number@ other SNP-protein associations in the ADNI sample exceeded genome-wide significance ( 5×10 ( @number@ ) ) .
@number@ Our research highlights the persistent effects of early development on reproductive performance in mammals.
@number@ out of @number@ patients ( @percent@ ) had concomitant eyelid surgery and @number@ ( @percent@ ) neck contouring procedure.
@number@ out of the @number@ patient fibroblasts ( @percent@ ) were responded to MA-5.
@number@ outpatients with diabetes mellitus were recruited for this prospective observational study.
@number@ P < 0.
@number@ P < 0.
@number@ pages of magazines published from @number@ to @number@ were reviewed ; @number@ articles met inclusion criteria.
@number@ parameters of trigeminal nerve roots were analyzed.
@number@ participants ( aged @number@.9 + / -8.4years , MMSE @time@ + / -8.13 ) took part.
@number@ participants attended the TILDA health centre for assessment.
@number@ participants between the ages of 5-74 years assigned colours to tactile stimuli.
@number@ participants have been recruited by stratified random sampling according to gender and departments.
@number@ participants ( @number@ ± @number@ years ) of the population-based Hoorn Study were included.
@number@ participants were first evaluated in @number@ @number@ @number@ and @number@ and follow-up was performed after @number@ years.
@number@ participants were random assigned to either the education empowerment group or in the comparison group.
@number@ participants were recruited with @number@ participants in each arm.
@number@ participants without glaucoma with gradable quality MRI and OCT scans were included for analysis.
@number@ patients accepted the MCA , constituting the intervention group.
@number@ patients had a spinal meningioma and neurofibromatosis.
@number@ patients had multiple lentigines solares of the lids.
@number@ patients had tumor in upper extremities and @number@ patients in lower extremities.
@number@ patients included were classified into age groups : patients aged 18-59 comprised Group-1 and those aged over @number@ comprised Group-2.
@number@ patients on maintenance hemodialysis for more than @number@ months at dialysis facilities affiliated with the Western Dialysis Physician Association were enrolled in @date@ .
@number@ patients ( @percent@ ) ended the study.
@number@ patients ( @percent@ ) underwent exenteration for a central pelvic recurrence , and the remaining @number@ patients ( @percent@ ) for radiation necrosis.
@number@ patients suffered from venous congestion and had to undergo revision surgery.
@number@ patients were excluded because of the weaning failure during T-tube trial.
@number@ patients were identified with at least one chronic disease.
@number@ patients were included in the study cohort of which @percent@ ( n = @number@ ) were male.
@number@ patients who did not receive enteral or parenteral nutrition were analyzed.
@number@ patients with MPAP > @number@ mmHg died before @number@ year of follow-up.
@number@ patients with neurological movement disorders of different origins and @number@ neurologically healthy subjects participated in the study.
@number@ patients with PHP-Ia and PPHP showed @number@ different mutations in the GNAS gene.
@number@ patients with PHP-Ib displayed a loss of differentially methylated region ( DMR ) imprints of the maternal GNAS.
@number@ @percent@ CI = 0.36 , @number@ ) .
@number@ ( @percent@ ) found this procedure acceptable and would have the procedure again.
@number@ ( @percent@ ) had a cardiovascular event or died from cardiovascular causes.
@number@ ( @percent@ ) had diabetes.
@number@ ( @percent@ ) individuals dropped out overall.
@number@ ( @percent@ of men and @percent@ of women ) died.
@number@ ( @percent@ ) of our seniors spent their free time alone at home.
@number@ ( @percent@ ) of people approached completed information about our main outcome measure , a single item measure of happiness.
@number@ ( @percent@ of screened ) had raised HADS ( ≥8 ) ; majority had indications of mild depression with HADS between @number@ and @number@
@number@ ( @percent@ ) participants had OH and @number@ ( @percent@ ) participants had OI.
@number@ ( @percent@ ) participants were back to their normal levels of activity one day after the procedure.
@number@ ( @percent@ ) persons in the experiment group and @number@ ( @percent@ ) in the control group completed the study.
@number@ ( @percent@ ) study participants deceased during the follow-up period.
@number@ ( @percent@ ) waited greater than @number@ h for emergency procedures.
@number@ ( @percent@ ) were male ; mean follow-up time was @number@ years.
@number@ ( @percent@ ) were older than @number@ years , in whom we analyzed the impact of renal function on various outcome parameters.
@number@ ( @percent@ ) were under treatment for depression and exempt from screening.
@number@ persons ( @number@ women , age @number@ ± @number@ years ; @number@ men , age @number@ ± @number@ years ) underwent a blood draw.
@number@ players as compared with all other numbers 2-10.
@number@ P < @number@ ) .
@number@ P @number@
( @number@ ) Postmenopausal motherhood can find legitimacy through the development and success of antiaging medicine.
( @number@ ) Prefer oral formulations of highly bioavailable antimicrobials whenever possible.
( @number@ ) Probiotic diets originated in Elie Metchnikoff's conception of radically prolonged \ "orthobiosis \ " ( c.
( @number@ ) Production of vasoconstrictor / vasodilator factor imbalances.
( @number@ ) . proposed the use of an age adjusted DD cut-off to increase the specificity of this test.
@number@ proteins were quantified on the basis of @number@ unique peptides.
( @number@ ) provide a strategy for inducing aging-related phenotypes in hiPSC-derived neurons , enabling in vitro study of late-onset neurodegenerative diseases.
( @number@ ) provide the first in vivo evidence of blood-brain barrier disruption in the aging hippocampus and in minimal cognitive impairment.
@number@ public school pupils aged 6-18 were studied ( 267-urban resident , 226-rural resident ) .
@number@'-RACE coupled with RT-PCR were used to analyse the effect of the c.103 + 1G > A mutation on mRNA splicing.
@number@ recommendations were formulated based on evidence from the literature and after discussion and consensus building in the group.
@number@ records of patients who were hospitalized at the Department of maxillofacial surgery and dentistry in three years has been studied.
@number@ records were retrieved for the analysis ( @percent@ women ) .
( @number@ ) Reduction of nitric oxide ( NO ) bioavailability , by diminished NO synthesis and / or augmented NO scavenging.
( @number@ ) Reductions in specific cognitive abilities for instance processing speed , executive functions , and episodic memory are seen in healthy aging.
@number@ Ref. @number@ ) .
( @number@ ) report RNA splice isoform signatures unique to patient-derived leukemic stem cells that constitute a therapeutic Achilles ' heel of myeloid leukemia.
( @number@ ) report that adult neurogenesis requires mitochondrial electron transport and oxidative phosphorylation and that disrupting these pathways induces premature aging phenotypes.
@number@ residents were recruited and completed baseline depression assessments.
@number@ respondents gave usable data ; those data were analyzed via a structural equation model.
@number@ respondents ( @percent@ ) thought their PMR was as a result of another medical condition.
( @number@ ) reveal how a mitochondrial metabolite ( mitobolite ) inhibits mitochondrial ATPase and extends lifespan by mimicking dietary restriction in worms.
@number@ ) RFs appear to interfere with the successful completion of astrocyte mitosis and cell division.
@number@ ) RFs continue to form within AxD astrocytes over time.
( @number@ ) SCF-KIT signaling induces timely local ET3 synthesis and secretion.
( @number@ ) Science , 319 : 916 ) .
@number@ + SED , but not @number@ + ACT , displayed a higher lipid content in type I fibres vs. YA.
@number@ + SED displayed a lower type IIa fibre proportion vs. YA.
@number@ serum proteins were recognized as partial mediators of age's association with δ.
( @number@ ) show that CHIP / CHN-1 also directly ubiquitylates the insulin receptor INSR / DAF-2 to regulate its turnover.
( @number@ ) Similar reports suggest that Hawaii's physician workforce lags @percent@ behind physician to population ratios in the continental US.
@number@ single donor derived HPLs ( @number@ to @number@ years old ) were simultaneously compared for culture of MSC.
Numbers needed to treat were small.
@number@ SNPs in @number@ genes ( MYLK , AQP4 , NINJ2 , and INK4 / ARF ) were genotyped using Multiplex Snapshot assay.
( @number@ ) Social changes included more coherent social interactions and making friends.
Numbers of analyses were performed to identify symptoms representing different aspects of aging.
Numbers of astrocytes and microglial cells do not appear to increase with age , but there is a @percent@ increase in oligodendrocytes.
Numbers of epidemiological and experimental studies have proved a complex chemiopreventive activity of resveratrol against various cardio-vascular disorders and cancer.
Numbers of globally sclerotic glomeruli in a kidney biopsy that exceed these thresholds suggest chronic pathological injury in excess of that expected with normal aging.
Numbers of HO-1-positive CA were significantly increased in certain hippocampal strata of MCI subjects relative to NCI preparations.
@number@ software.
@number@ Software.
@number@ software was used to analyze the database , t . test , chi2 test , one-way-ANOVA and Logistic regression were used for analysis.
@number@ St Clair et al.
( @number@ ) Studies controlling confounders.
( @number@ ) Studies controlling multiple confounders.
@number@ studies have been retrieved.
@number@ studies published in English from @number@ to @number@ were included.
@number@ studies were included.
@number@ ) subjects design , but still found no evidence of the survival advantage in this age group.
@number@ subjects - including @number@ with VH and @number@ without VH - were selected from the Arizona Study of Aging and Neurodegenerative Disorders.
@number@ subjects - longitudinal retest study.
@number@ subjects participated and were followed up for vital status after @number@ months.
@number@ subjects reported levothyroxine use and were evaluated separately.
@number@ subjects walked with no wedges ( control condition ) and wearing six different wedges.
@number@ subjects were additionally prescribed Varenicline according to their own choice and reported data were compared to those without Varenicline.
@number@ subjects were hospitalized once , @number@ twice , @number@ three times , @number@ four times and @number@ five times during the two-year follow-up.
@number@ subjects were selected from a large , prospective hospital-based study.
@number@ surveys were returned , and @number@ ( @percent@ ) were usable for the analysis.
Numbers used for comparisons were small.
( @number@ ) Temporally- and spatially-precise NO generation.
@number@ ) TGF-β promotes expression of Nanog , a transcription factor that retains MSC in a primitive state.
( @number@ ) That axonal transport to and from neuron soma cannot account fully for high mitochondrial densities and other requirements of distant terminal axons.
( @number@ ) That neurons as specialists in information management , delegate generic support functions to astrocytes and other cell types.
( @number@ ) The above @number@ biomarkers are competent for the evaluation of aging.
( @number@ ) The acceptance of postmenopausal motherhoods in our society first requires that antiaging medicine itself find some sort of ethical legitimacy.
( @number@ ) The accidents occurred more frequently from March to August each year.
[ @number@ ] The authors could not show any significant improvement in constitutional or sexual symptoms in this group of men.
( @number@ ) The brain bank accepts brain donation and maintains a clinical longitudinal follow-up record of the donor.
( @number@ ) The brain bank provides useful resources to researchers.
( @number@ ) The brain bank resource is quality controlled and its information is shared by researchers.
( @number@ ) The development of clinical endocrinology owed much to Eugen Steinach's \ "endocrine rejuvenation \ " operations ( c.
@number@ ) The development of P4 Systems medicine inspired new methodologies in the predictive maintenance.
( @number@ ) The expression changes of senescence related genes were verified using RT-qPCR.
@number@ ) The high ADL group showed a high level of serum zinc concentration.
( @number@ ) The level of GA in the @number@.5th to @number@.5th percentile was @number@.8%-17.1%.
( @number@ ) The photopic hill effect was less pronounced.
@number@ ) There was no significant difference between men ( 20° ) and women ( @number@.8° ) ( p = @number@ ) .
( @number@ ) The volumetric brain reductions in healthy aging are likely only to a minor extent related to neuronal loss.
( @number@ ) ' They have their own busy life. '
@number@ ( this issue of Cell Metabolism ) promotes biosynthesis of an endogenous AMP analog , AICAR.
@number@ ) through age @number@
@number@ @time@ @number@ ) .
@number@ @time@ @number@ ) .
( @number@ ) Tissue engineering was pioneered during Alexis Carrel's work on cell and tissue immortalization ( c.
@number@ T MR images of the knee were acquired at baseline , @number@ year and @number@ years.
( @number@ ) To determine if measurements of hippocampal subfields provide advantages over total hippocampal volume for differentiation between groups.
( @number@ ) To determine whether greater treatment intensity is associated with longer life.
( @number@ ) To utilize these models to develop normograms , given the level of caloric restriction prescribed , and measures of these variables.
@number@ T postmortem MRI distinguishes different histopathologic types of cortical CMIs , with distinctive MR characteristics.
( @number@ ) Two months later , the ICG , BDI and IES-R assessments were repeated.
@number@ units of abobotulinumtoxinA was injected in @number@ equal aliquots ( @number@ units each ) into each of @number@ injection sites in the glabellar complex.
@number@ unrelated Chinese nonagenarians and centenarians participated in the study.
@number@ unrelated healthy individuals ( age range 8-106 years , @number@ males and @number@ females ) from central Italy were studied.
@number@ up-regulated genes were enriched mainly in mitotic cell cycle and DNA repair mechanisms , while @number@ down-regulated genes were involved primarily in mitochondrial activity.
@number@ villages ( Cama / Lostallo ) have already been selected as initial study sites.
( @number@ % vs @number@ % OR @number@ @number@ % CI [ @number@ @number@ ] p = @number@ ) .
@number@ % wanted to make their own decisions with regard to end-of-life care , which was most important for people with higher education.
@number@ % wanted to predetermine decisions by means of an advance directive in case they are no longer able to make them at the time.
( @number@ ) was provided to staff members of a facility to help healthcare providers develop personal insight into the aging process through role play.
@number@ was used to review the literature.
@number@ ) We predict and validate the expression level of a transcription factor involved in pluripotency.
@number@ were ApoE4 positive ( ApoE4 + ) ( @number@ heterozygous and @number@ homozygous ) and @number@ were ApoE4 negative ( ApoE4- ) .
@number@ were assessed as the T1D patients and @number@ as the LADA ones.
@number@ were identified as deceased.
@number@ were identified as malnourished ( MN ) or at risk of malnutrition ( AR ) .
( @number@ ) ' What would I do without them ? '
@number@ ) women and @percent@ at @number@ yr for no.
@number@ women were included in this study via an osteoporosis consultation.
@number@ workstations were subjected to measurements in order to determine the level of noise , lighting and heat.
@number@ ya ( around @number@ ) after major anthropogenic disturbances ceased.
@number@ years ago life expectancy was between @number@ to @number@ years , but today close to @number@ million people are @number@ yeas old or more.
@number@ years ) compared to younger ( avg.
@number@ years ) individuals.
@number@ years later , we re-investigated the same participants , with @percent@ participation rate.
@number@ young and @number@ older adults completed an Archimedes spiral tracing task on a touchscreen mounted on a force sensor.
@number@ younger and @number@ older healthy individuals were separately selected for two age groups , from a physical examination database.
@number@ young subjects ( 20-28 years old ) were investigated as controls.
@number@ youth ( @percent@ ) regained insurance.
@number@ μg / mL TRF treatment exhibited the highest cell proliferation capacity.
Numerical analyses are performed to identify the stress-strain behavior of the plantar fat pad considering healthy and degenerative configurations.
Numerical and functional impairments in this unique T-cell subpopulation may contribute to diminished angiogenic potential and greater cardiovascular risk with advancing age.
Numerical and structural karyotypic analysis has shown hypodiploidy karyotypic : @number@ @date@ in this line.
Numerically , VFE registered slightly greater adherence to home practice recommendations than did PhoRTE , but PhoRTE perceived greater treatment satisfaction than VFE.
Numerical Rating Scale and Oswestry Disability Index were statistically correlated with vertebral instability but not with local kyphotic angle and presence of posterior wall fracture.
Numerical values for RIA were approximately one seventh of EqD values.
Numerical values of bone mineral density were lower in the sarcopenic population but the differences did not reach the level of statistical significance.
Numerosity discrimination improved after training and was maintained long term , especially in the training + parietal stimulation group , regardless of age.
Numerous activities require an individual to respond quickly to the correct stimulus.
Numerous alterations in tendon properties were detected across age groups , including inferior material properties ( maximum stress , modulus ) with increasing age.
Numerous attempts have been launched to identify specific inducers or inhibitors of autophagy and to use them for the therapeutic correction of its deregulation.
Numerous behavioral studies have suggested that normal aging negatively affects source memory accuracy for various kinds of associations.
Numerous concerns about health insurance were expressed , including the unavailability of Medicare and reductions in Tricare.
Numerous conditions including neuromuscular disorders , physical inactivity , chronic disease and ageing are associated with perturbations in skeletal muscle function.
Numerous cross-sectioned blood vessels were seen in the lamina propria near the free edge , and near the superior and inferior surfaces of the VF.
Numerous decision-making situations occur in the activities of daily living.
Numerous disease processes are associated with shifts in steady state ROS levels that influence overall ECM degradation.
Numerous disorders , including neurodegenerative diseases and certain types of cancer , manifest late in life.
Numerous disparities between results for reflex and operant escape measures are described , but the results of operant testing are consistent with evidence from humans.
Numerous emerging technologies have potential as therapeutic options.
Numerous evidence indicate that aging is associated with alterations of several mechanisms whose integrity confers protective action on the heart and vasculature.
Numerous exogenous and endogenous sources of ROS are present in pathobiology of COPD.
Numerous exogenous compounds have been tested for their anti-glycating activity.
Numerous findings report a rise in activity , especially on SIRT1 , in a diversity of cells and animal models after melatonin treatment.
Numerous frailty scales have been developed for case identification and stratification of risk of adverse outcomes.
Numerous gene mutations and treatments have been shown to extend the lifespan of diverse organisms ranging from the unicellular Saccharomyces cerevisiae to primates.
Numerous health benefits are associated with a physically active population.
Numerous human diseases result from the failure of proteins to fold properly in response to mutation , disrupting the proteome.
Numerous investigations have examined the effects of glucocorticoid receptor ( GR ) activation prior to inflammatory challenges.
Numerous isomerization hotspots were also identified and occur in regions with aspartic acid and serine repeats.
Numerous medical co-morbidities and medications can alter testosterone levels resulting in a wide range of nonspecific clinical signs and symptoms of TD.
Numerous mHealth interventions exist for this population , yet the effect of these interventions on health has not been systematically described.
Numerous molecular biomarkers have been proposed as predictors of chronological age.
Numerous mutations in the human A-type lamin gene ( LMNA ) cause the premature aging disease , progeria.
Numerous neuroimaging studies have consistently demonstrated an age-related decrease in DAT density in normal human brain.
Numerous observational and intervention-based human studies support the notion of a beneficial role for dietary flavonoids in human health.
Numerous online resources exist for both nurses and older adults to increase knowledge of STIs.
Numerous parametrisations and re-parametrisations of varying usefulness are found in the literature , whereof the Gompertz-Laird is one of the more commonly used.
Numerous physical , psychological , and social health consequences were identified.
Numerous plant-based products ( phytomedicines ) are increasingly used as an alternative or complement the conventional medication.
Numerous procedures for facial skin rejuvenation have been developed in an attempt to minimize the erythema , dyspigmentation , and rhytides associated with photoaging.
Numerous proteins possess Nudix homology domains ( NHDs ) that have no known function.
Numerous publications have reported their role as stem cells , contributing to the formation of tissues other than blood vessels.
Numerous recent studies have found that overweight adults experience lower overall mortality than those who are underweight , normal-weight , or obese.
Numerous reports have highlighted that these diseases are occurring at an earlier age among HIV-infected persons.
Numerous reports show that efficacy of medical treatment depends on the age of treated subjects.
Numerous risk factors have been reported but the evidence and strength of association is variable.
Numerous search terms relating to withdrawal of medications and consumers ' beliefs were utilised.
Numerous smartphone applications currently support patient self-management of chronic disease , facilitating health management and health promotion.
Numerous studies demonstrated that F2-isoprostanes , markers of in vivo lipid peroxidation , are elevated in AD patients and mouse models of the disease.
Numerous studies have also found that older adults perform more poorly on working memory tasks than young adults ( YA ) .
Numerous studies have been made in recent years addressing the effect of physical exercise on brain cortical activity and changes in mood.
Numerous studies have confirmed this hypothesis from in utero to aging works.
Numerous studies have demonstrated increased flux through this pathway contributes to the development of β-cell dysfunction.
Numerous studies have demonstrated that the proteasome plays a pivotal role in the selective recognition and degradation of oxidized proteins.
Numerous studies have found both common and rare genetic variants in the complement pathway to play a role in the pathogenesis of AMD.
Numerous studies have investigated age-based declines in semen traits , but the impact of paternal age on semen parameter values remains inconclusive.
Numerous studies have shown associations between the FOXO3A gene , encoding the forkhead box O3 transcription factor , and human or specifically male longevity.
Numerous studies have shown sex differences in the vasculature , kidney and sympathetic nervous system contribute to this sex difference in the development of hypertension.
Numerous studies have shown that activation of the p53 / p21 pathway inhibits the proliferation of BM-MSCs.
Numerous studies have shown that alcohol intake causes neuropsychological disorders that affect various brain structures.
Numerous studies have shown that SOD has been elevated in chronic schizophrenic patients.
Numerous studies have shown that there are acute cognitive side-effects of chemotherapy for breast cancer.
Numerous studies in the current literature have argued the importance of social engagement in ageing , particularly for cognitive health.
Numerous studies suggest that women who experience IPV have poorer overall health.
Numerous systemic or cellular inflammatory , immune activation , oxidative stress , or senescence markers can be tested in serum or peripheral blood mononuclear cells.
Numerous therapeutic interventions and neuroprotective approaches are also in trial phase.
Numerous trials have demonstrated reduction in these adverse outcomes with antihypertensive drugs.
Numerous unfavorable factors that disturb the balance between resorption and bone formation affect bone mechanical strength.
NUMT abundance in tumor predicted parallel abundance in blood.
NUMT abundance positively correlated with GC content and gene density.
Nur77 deficiency compromises response to leptin in mice fed a high-fat diet.
Nurse and the Public health nurse are also the important members of the medical team for TB.
Nurse group interviews were carried out twice.
Nurse practitioner and social work students had higher positive attitudes toward the care of older adults.
Nurse practitioners can ease increased pressure on primary care shortage while providing a cost-effective and high-quality alternative to certain physician services.
Nurse practitioners can effectively detect and motivate people with metabolic syndrome.
Nurse-reports of victimization of relational aggression were not related to subjective well-being.
Nurse residency programs are used to retain new graduates and assist with their transition to nursing practice.
Nurses aged over @number@ represent @percent@ of the workforce at both TH.
Nurses and carers are in a prime position to prevent , assess and manage skin tears.
Nurses are encouraged to nonjudgmentally assist older women to enhance their well-being , despite IPA.
Nurses are ideally placed to provide advice on nutrition and physical activity to older people in an effort to reduce the burden of age-related disease.
Nurses can eliminate unnecessary medications and seek safer alternatives for potentially inappropriate medications.
Nurses can lead in improving the mobilization of older critical care patients , thus reducing clinical risk in this vulnerable population.
Nurses care for individuals and are uniquely present to intervene throughout all stages of the transitioning process.
Nurses completed the OPACS-US section A : practice experiences , B : general opinion and the KOP-Q online.
Nurses could not identify delirium in @number@ % of patients compared with researchers.
Nurses found the purpose of the tool to be confusing.
Nurses have an important role in the nutritional support of older cancer patients.
Nurses have the potential to play an expanded role in ICU communication and decision making.
Nurses in all practice areas will care for cancer survivors and must be prepared to deliver safe and effective care.
Nurses ' knowledge of clinical investigations was consistently lower than their knowledge of therapy and clinical symptoms.
Nurses need support from leaders in four areas to provide function-focused care to older people in the current hospital context.
Nurses need to be especially aware of and monitor for these problems.
Nurses of the future will be faced with the task of caring for this elderly population.
Nurses play an important role as frontline providers who care for aging adults.
Nurses should assess older breast cancer patients keeping in mind physical functioning , comorbidities , social support network , and quality of intimate partner support.
Nurses should assess the geriatric needs in patients at risk and based on these initiate and coordinate multi-professional interventions.
Nurses should consider how cultural and individual perspectives affect the care priorities of older people.
Nurses ' training totaled @number@ hours ( @number@ onsite and @number@ via the web ) .
Nurses using public health approaches can lead and support social policies regarding the physical environment and daily life circumstances that contribute to health equity.
Nurses will be challenged to recognise the coping strategies of older adults , particularly considering their deficits in health knowledge.
Nurses working longer on the ward , with lower education , presented higher barriers to discontinuation of antipsychotics.
Nursing facilities are part of a dynamic network of care characterized by frequent transitions.
Nursing home ( NH ) residents routinely complete surveys that assess their health , well-being , preferences , and care needs.
Nursing home residence , female sex , and greater number of drugs predict non-rational long-term use of PPI. © @number@ The Authors.
Nursing home residents had the lowest age-adjusted mean grip strength and community rehabilitation referrals the highest.
Nursing homes can integrate the findings from the intervention trial into their internal quality control process.
Nursing homes have become complex care environments where residents have significant needs and most have age-related dementia.
Nursing homes must engage patients in advance care planning , but do so inconsistently.
Nursing home staff members received a 6-week educational intervention on the types and treatment of urinary incontinence and attitudes toward urinary incontinence.
Nursing home staff report many varied responses to R-REM , a common and dangerous occurrence.
Nursing home staff responses may significantly mitigate R-REM's impact , but little is known about current practices.
Nursing home staff should be particularly vigilant in the days following the new prescription for a benzodiazepine in an effort to prevent injury.
Nursing home use by in-laws does not have the same impact , suggesting that individuals are responding to information gained about their own aging trajectory.
Nursing is a physically demanding profession and many older nurses work in pain while providing direct patient care.
Nursing is the largest segment of the healthcare workforce , but over the next decade even more nurses will be required.
Nursing pain related documentation was sparse.
Nursing research and practice both involve evaluating processes to gain a holistic understanding of patients through multiple means of data collection.
Nursing telephonic and tele-counseling individualized lifestyle educational programs have been found to improve blood pressure control and adherence to lifestyle recommendation.
Nutraceuticals derived from foods and herbs have been long used in traditional medicine , and many have wide-ranging biologic effects suggesting novel mechanisms of action.
Nutrient and food group intakes per @number@ kcal were evaluated using a brief self-administered diet history questionnaire.
Nutrient densities and critical densities were computed.
Nutrient densities , critical densities and main sources of nutrients were computed.
Nutrient formulas B and C were especially effective in reversing complex I dysfunction in both skeletal muscle and heart muscle.
Nutrient intake was adjusted for energy intake by residual method.
Nutrient sensing pathways become deregulated with age and lose effectiveness with age.
Nutrient sensing pathways that maintain glucose homeostasis in body are involved in regulation of aging.
Nutrient signaling to CAPER induces mitochondrial transcription and glucose-dependent mitochondrial respiration via coactivation of nuclear receptor ERR-α-mediated Gabpa transcription.
Nutrients including carbohydrates , proteins , lipids , vitamins , and minerals regulate various physiological processes and are essential for the survival of organisms.
Nutrients present in various foods plays an important role in maintaining the normal functions of the human body.
Nutrients , such as fats , sugars , and proteins , play a primary function in bone metabolism and maintaining bone health.
Nutrients were log transformed and calorie adjusted.
Nutrition across the lifespan encompasses both preventative and treatment options to maintain health and vitality.
Nutritional and biochemical indices , intestinal micro bacteria and immunological indices were analyzed.
Nutritional and cognitive aspects are closely related in dementia.
Nutritional and inflammatory proteins and cytokines ( IL-6 and TNF ) were measured at day @number@ and @number@
Nutritional and physical activity interventions may be designed in this regard.
Nutritional assessment included MNA , anthropometric measurements , and biochemical markers.
Nutritional assessment should be part of the routine preliminary evaluation of the older oncology patient.
Nutritional competence appears vital for residents to be well-nourished.
Nutritional deficiencies , which are extremely common among elderly population worldwide , have potential to impact the existence and rehabilitation of both syndromes.
Nutritional deficit was considered to be present if the individuals were classified as malnourished or at nutritional risk by means of the MNA.
Nutritional deprivation or calorie restriction as well as several nutriceuticals including resveratrol , spermidine , curcumin and piperine can enhance autophagy and increase lifespan.
Nutritional factors like Se and omega-3 fatty acids contained in sea fish were crucial to longevity.
Nutritional failure was defined as BMI < 10 percentile and / or fat-free mass index < 5th percentile.
Nutritional geometry is a state-space modelling approach that explores how animals respond to and balance changes in nutrient availability.
Nutritional intake , physical activity , and level of comorbidity were not associated with sarcopenia.
Nutritional interventions particularly through population-based educational programs in order to improve diet variety and consume nutrient supplements may be necessary.
Nutritional modulation of the microbiome can also be important , and there are long-term , including inter-generational , effects of diet.
Nutritional parameters were collected preoperatively , @number@ and @number@ days after surgery.
Nutritional practices develop over the life course.
Nutritional problems and deficiencies are widespread in geriatric institutions.
Nutritional problems , such as malnutrition , dehydration , and electrolyte imbalance , are multifaceted and complex issues for older adults.
Nutritional risk contributes significantly to subsequent depressive symptoms and is a strong and consistent predictor of subsequent depressive symptoms in nearly-old and old Taiwanese.
Nutritional risk may affect the disablement process that leads to health services utilization and death.
Nutritional risk was assessed using questions associated with the DETERMINE checklist.
Nutritional status and obesity were defined according to World Health Organization standards.
Nutritional status , body weight , body mass index , serum albumin were performed at the beginning of the study and at a two-year follow-up.
Nutritional status including anthropometry and biochemical tests , and wound status by a structured severity tool , were evaluated over @number@ weeks.
Nutritional status , mobility , activity , strength , endurance , cognition , and mood have been proposed as markers of frailty.
Nutritional status was assessed by Mini Nutritional Assessment.
Nutritional status was assessed by the Mini Nutritional Assessment and Body Mass Index.
Nutritional status was assessed by using the mini-nutritional assessment ( MNA ) .
Nutritional status was determined on admission by trained dietitians using the full MNA instrument and the MNA-SF.
Nutritional status was evaluated using the mini-nutritional assessment ( MNA ) .
Nutritional status was evaluated using the Mini Nutritional Assessment® ( MNA ) questionnaire.
Nutritional status was measured with the Mini Nutritional Assessment , and blood tests were conducted to assess a range of nutritional and clinical aspects.
Nutritional supplementation lead to further losses of intermuscular fat ( p = @number@ ) and increased normal muscle density ( p = @number@ ) .
Nutritional supplements such as , leucine and essential amino acids produced gains in muscle mass.
Nutritional value is important for people of all sexual orientations.
Nutrition and exercise instruction should be considered for early stage and even non-elderly CLD as well as LC.
Nutrition combined with exercise is important in supporting older people's health , functional capacity and quality of life.
Nutrition during critical periods of development is one of the pivotal factors in establishing a lifelong healthy metabolism.
Nutrition educational programs should be based on knowledge derived from research to tailor individualized nutritional interventions and to realize effective educational programs.
Nutrition exerts a life-long impact on human health , and the interaction between nutrition and health has been known for centuries.
Nutrition has a strong impact upon epigenetic processes and , therefore , holds promise in having important roles in regulating longevity and aging.
Nutrition is an important factor in many physiological and pathological changes that accompany the aging process.
Nutrition is one aspect of active ageing , but little is known about how food activities contribute to psychological well-being in later life.
Nutrition is vital for optimal growth and development of young children.
Nutrition may be a key element of multimodal interventions for frailty and sarcopenia.
Nutrition monitoring in the region is limited , and gaps in relevant information present challenges for implementing new policies and approaches to address the problem.
Nutrition programs aimed at preventing changes to extreme BMI might be productive.
Nutrition risk screening can facilitate early intervention when followed by nutritional assessment and treatment.
Nutrition risk was mildly associated with CVD.
Nutrition should be part of bone disease prevention strategies , especially in light of the aging population and the effect of diet on bone health.
Nuts and seeds could reduce disease and prolong life by influencing telomeres.
NY-ESO-1 is a major target of CD8 OBJECTIVE : Mild cognitive impairment ( MCI ) is considered an intermediate stage between normal aging and dementia.
NYHA class improved in @number@ patients and trend to increase number of METS during exercise test ( p = @number@ ) was found.
Nyquist plots provide interpretable patterns to portray the vibratory characteristics as clear , pressed , breathy , and atypical patterns.
O2 ( -• ) / H2O2 were once viewed as unfortunately by-products of aerobic respiration.
O2 ( -• ) is then rapidly dismutated by superoxide dismutase ( SOD ) producing H2O2.
OA-associated epigenetic aberrations have been noted at the level of DNA methylation and histone modification in chondrocytes.
OAB would obviously affect the quality of life of the aging men.
OA cohort showed significant positive correlations between Total Brain Volume and SDM , Digit-Backwards span and RT.
OAC underuse was observed in @percent@ of the stays.
OA-induced financial and social burdens have become an increasingly severe threat to older population.
OA occurs through complex and dynamic interplays between diverse factors over long periods of time.
OA patients showed reduced ( P < @number@ ) knee extensor function.
OA patients were defined as participants with knee / hip joint pain and radiographic change of knee / hip joint.
OASCs were isolated from the fat samples , expanded in vitro and cultured under appropriate inducive conditions.
Oatmeal also showed changes in texture with fortification.
Oatmeal liking did not differ between fortified and unfortified samples.
Oats are known to be a healthy food for the heart due mainly to their high beta-glucan content.
OATS offers an excellent opportunity for collaboration with other similar studies as well as researchers who share the same interests.
Oaxaca-Blinder decomposition partitioned the two-group inequalities into explained and unexplained components.
OB , CP + P and SE + P presented more silver uptake.
Obese females reported sitting more than normal weight and overweight females ( p = 0.0008 ) .
Obese is a strong risk factor for diabetes incidence among women of all ages , and especially among young adults.
Obese males were @percent@ [ odds ratio : @number@ ( @number@.4-2.7 ) ] more likely to be hypertensive compared to normal weight males.
Obese older adults are particularly susceptible to sarcopenia and have a higher prevalence of disability than their peers of normal weight.
Obese older adults with even modest functional limitations are at a disadvantage for maintaining their independence into late life.
Obese participants in midlife showed an adjusted mean difference ( @percent@ confidence interval ) of @number@ ( @number@ @number@ ) compared with non-obese.
Obese participants were found to have a significantly higher prevalence of foot pain and scored significantly lower on the SF-36.
Obese subjects were followed every @number@ months.
Obese women had lower achievements for almost all recommended HEI components.
Obesity 1st and 2nd grade were present together only in @percent@.
Obesity , aging and family history of diabetes were strongly predictive of gestational diabetes.
Obesity also causes several aging related-disorders such as cancer , strokes , cardiovascular disease , high blood pressure and type @number@ diabetes.
Obesity also impaired functional performance , as indicated by higher rates of strength loss , increases in discomfort , and declines in task performance.
Obesity alters GORD pathogenesis by disrupting the OGJ and increasing intragastric pressure.
Obesity , a major health problem reaching global epidemic proportions , is also associated with morbidity and mortality.
Obesity among the elderly is a growing public health concern.
Obesity and aging are associated with increased SNS activity , and weight loss and / or exercise seem to have positive effects on this balance.
Obesity and aging are interrelated conditions that both cause changes in adipocyte metabolism and affect the distribution of fat in both subcutaneous and visceral depots.
Obesity and aging can modify job demands and affect worker capacity in terms of muscular and psychomotor function.
Obesity and its related metabolic disorders are closely correlated with gut dysbiosis.
Obesity and larger LA volumes are independently associated with reduced LA compliance.
Obesity and physical activity are the main modifiable factors associated with symptom severity.
Obesity and sarcopenia were defined according to the body mass index and the skeletal muscle mass index , respectively.
Obesity and sarcopenia were defined using revised National Cholesterol Education Program ( NCEP ) obesity guidelines and those of the Asian Working Group for Sarcopenia.
Obesity and sedentariness were risk factors of MCRv , MCRsl , and MCRsw.
Obesity and type @number@ diabetes have become the major health problems in many industrialized countries.
Obesity appears to be such a promoting factor and has been linked in several studies to sarcopenia.
Obesity attenuated the FSH rise and delayed the initial increase to @number@ yr before the FMP.
Obesity ( BMI≥ @number@ ) was a high risk factor for knee OA ( P < @number@ ) .
Obesity can adversely affect human health , including fertility.
Obesity causes dysfunction of adipose tissue , with resultant chronic inflammation and adverse interplay of various adipokines , sex steroids and endocrine hormones.
Obesity currently affects about one-third of the U.S. population , while another one-third is overweight.
Obesity has always been considered a protective factor for the skeleton and for osteoporosis.
Obesity has been characterized as a state of chronic inflammation.
Obesity , high triglycerides , and dyslipidemia were not associated with carotid artery plaque or cIMT.
Obesity / HIV status was the primary predictor.
Obesity , hyperglycemia , and dyslipidemia were prevalent and increased from NFG to IFG and T2D.
Obesity-induced inflammation interacts with both these mechanisms and disturbs iron availability by impairing its absorption , and by sequestering it in the reticuloendothelial system.
Obesity induces insulin resistance in the skeletal muscle , which consequently leads to perturbed metabolism , and misrouted signaling in the muscle cells.
Obesity in older adults affects not only morbidity and mortality but , importantly , quality of life and the risk of institutionalization.
Obesity , insulin resistance and ageing are all associated with impaired microvascular responses to insulin in skeletal muscle.
Obesity is a long-term source of cellular stress that predisposes to chronic kidney disease ( CKD ) .
Obesity is a major health problem , contributing to the development of various diseases with aging.
Obesity is a risk factor for chronic kidney disease , and its prevalence among the elderly is increasing.
Obesity is associated with adipocyte hypertrophy and proliferation as well as with shorter telomeres in adipose tissue.
Obesity is associated with altered activity of brain networks sensing food-related stimuli and internal signals of energy balance , which modulate eating behaviour.
Obesity is associated with both structural and functional changes of the central nervous system.
Obesity is associated with increased cardiovascular morbidity and mortality , inflammation , and elevated cortisol levels.
Obesity is associated with increased risk in hepatocellular carcinoma ( HCC ) development and mortality.
Obesity is a worldwide epidemic , with major health and economic costs.
Obesity is heritable and predisposes to many diseases.
Obesity is increased in the elderly population , and adipose tissue induces a state of systemic inflammation partially induced by adipokines.
Obesity is often regarded as the primary cause of metabolic syndrome.
Obesity is one of the greatest public health challenges in the world with childhood prevalence rates between 20-26% and numerous associated health risks.
Obesity is usually accompanied by an increased muscle mass.
Obesity , metabolic syndrome , and diabetes are becoming a leading health concern in the developed Countries , due to their link to cardiovascular disease.
Obesity , metabolic syndrome , and type @number@ diabetes ( T2D ) are related disorders with widespread deleterious effects throughout the body.
Obesity phenotypes were measured from anthropometric assessments when study members were aged 18-26 and again when they were 24-32.
Obesity prevalence was significantly higher in breakfast skippers than in breakfast eaters ( @percent@ vs. @percent@ , P = @number@ ) .
Obesity-related impairments may have implications for the design of work duration and demand level to prevent fatigue development for workers who are obese.
Obesity results in an imbalance between endothelium-derived vasoactive factors favouring vasoconstriction , cell growth and inflammatory activation.
Obesity , sarcopenia , and osteoporosis are important widespread health problems that lead to high prevalence of both mortality and morbidity.
Obesity significantly interacted with the TCF7L2-rs7903146 on T2D prevalence , associations being greater in non-obese subjects.
Obesity , smoking behavior , and being Chinese or Japanese were associated with some variation in E2 levels but not the pattern of E2 change.
Obesity , smoking , diabetes , hypertension , and cardiac and metabolic conditions , but not intellectual enrichment , were associated with greater AD-pattern neurodegeneration.
Obesity strongly predicted gross mobility ( GM ) disability , and the number of chronic conditions strongly predicted all outcomes , especially in women.
Obesity symbolizes a major public health problem.
Obesity , together with aging and injury , is among the main risk factors for osteoarthritis.
Obesity was also associated with reduced exercise time and functional capacity , and BMI independently correlated with reduced exercise tolerance.
Obesity was defined according to body mass index.
Obesity was defined as BMI ≥30 kg / m ( @number@ ) .
Obesity was defined as BMI z-score ≥1.64 and overweight defined as BMI z-score ≥1.04 but < 1.64.
Obesity was defined by body mass index.
Obesity was measured using the body mass index ( BMI ) in World Health Organization ( WHO ) Asia criteria.
Obesity was not a predictor.
Obesity , whose prevalence is increasing , is associated with poor functional status at older ages.
Obidoxime was by far the most effective reactivator with all tested species.
OBJECT : A spinal epidural abscess ( SEA ) is a rare but severe infection requiring prompt recognition and management.
OBJECT : Automated eye movement tracking may provide clues to nervous system function at many levels.
OBJECT : Degenerative changes of the interspinous ligaments ( ISLs ) have generally been ignored in previous studies.
OBJECT : Hemorrhagic origin is unidentifiable in 10%-20% of patients presenting with spontaneous subarachnoid hemorrhage ( SAH ) .
Objective.
OBJECTIVE.
OBJECTIVE.
OBJECTIVE : A 24-week study evaluated clinical efficacy with HA.
OBJECTIVE : Acceleration of amyloid A ( AA ) amyloidosis induction by ageing has not been extensively studied in rheumatoid arthritis ( RA ) .
OBJECTIVE : Accumulation of mitochondrial DNA ( mtDNA ) damage has been associated with aging and abnormal oxidative metabolism.
OBJECTIVE : Accurate estimates of the incidence and prevalence of epilepsy allow us to better assess its societal impact.
OBJECTIVE : Acetylcholinesterase inhibitors ( AChEIs ) may reduce the oxidative stress in brain of Alzheimer's disease ( AD ) patients.
OBJECTIVE : A challenge for implementing high bandwidth cortical brain-machine interface devices in patients is the limited functional lifespan of implanted recording electrodes.
OBJECTIVE : a comprehensive literature review suggests that suicidal behaviour results from a complex interplay between stressful events and vulnerability factors including cognitive deficits.
OBJECTIVE : Adipocyte infiltration of the musculoskeletal system is well recognized as a hallmark of aging , obesity , and type @number@ diabetes.
OBJECTIVE : A disintegrin and metalloproteinase ADAM17 ( tumor necrosis factor-α [ TNF ] -converting enzyme ) regulates soluble TNF levels.
OBJECTIVE : Adults seeking services from the Aging Services Provider Network ( ASPN ) are at risk for depression.
OBJECTIVE : Adults with serious mental illness are disproportionately affected by general medical comorbidity , earlier onset of disease , and premature mortality.
OBJECTIVE : Adventitial collagen structure provides the aorta with tensile strength.
OBJECTIVE : Ageing is associated with modifications in upper oesophageal sphincter function that may be deleterious to deglutition.
OBJECTIVE : Age-related abnormalities in caudate volumes have been reported to differ across the periods of childhood and puberty in children with ADHD.
OBJECTIVE : Age-related changes are well documented in the primary somatosensory cortex ( SI ) .
OBJECTIVE : Age-related neurodegeneration may interfere with the ability to respond to cross-limb transfer , whereby bilateral performance improvements accompany unilateral practice.
OBJECTIVE : Aging causes changes in nasal morphology and function.
OBJECTIVE : Aging decreases the strength of association between established coronary heart disease ( CHD ) and its risk factors.
OBJECTIVE : Aging is a major risk factor for osteoarthritis ( OA ) .
OBJECTIVE : Aging is associated with a loss of cognitive performance and an increasing occurrence of cardiovascular events.
OBJECTIVE : Aging is associated with cognitive changing.
OBJECTIVE : Aging is associated with decreases in muscle mass , strength , power ( sarcopenia ) and bone mineral density ( BMD ) .
OBJECTIVE : Aging is often associated with declines in episodic memory.
OBJECTIVE : Agitation post-acquired brain injury ( ABI ) is common and should be appropriately managed to optimize the patients ' rehabilitation progress.
OBJECTIVE : Aim of this observational study is the evaluation of olfactory and gustatory impairments in laryngectomized long-term survivors compared to control subjects.
OBJECTIVE : A limited but growing body of evidence supports a significant role of antioxidant and anti-inflammatory micronutrients in pulmonary health.
OBJECTIVE : Alkaptonuria ( AKU ) is a rare autosomal recessive disease resulting from a single enzyme deficiency in tyrosine metabolism.
OBJECTIVE : All-cause mortality after hip fracture was investigated to assess its magnitude.
OBJECTIVE : Alterations of blood and plasma viscosity can promote atherosclerosis.
OBJECTIVE : Altered circadian rhythms have been identified in untreated prostate cancer patients.
OBJECTIVE : Although attachment dynamics are thought to be important across the life span , relatively few studies have examined attachment processes beyond young adulthood.
OBJECTIVE : Although the epidemiology and prevention of falls has been well studied , the focus has been on indoor rather than outdoor falls.
OBJECTIVE : Although the relationship between cognitive function and plasma lipids has attracted attention , previous studies have shown conflicting results.
OBJECTIVE : Alzheimer's disease ( AD ) is a heterogeneous disorder with complex underlying neuropathology that is still not completely understood.
Objective : : Among all countries , Brazil is expected to have the sixth largest elderly population in @number@
OBJECTIVE : AMP-activated protein kinase ( AMPK ) inhibits chondrocyte procatabolic responses to inflammation and biomechanical injury.
OBJECTIVE : Analysing dietary data to capture how individuals typically consume foods is dependent on the coding variables used.
OBJECTIVE : Analysis of skull thickness at the area of halo pin insertion site.
OBJECTIVE : Analyze the use of antihypertensives among seniors and the association with socioeconomic and behavioral characteristics.
OBJECTIVE AND BACKGROUND : Amitriptyline is one of the most commonly used medications in migraine prophylaxis.
OBJECTIVE AND HYPOTHESIS : To investigate whether old age frailty is predicted by midlife overweight / obesity and cardiovascular disease ( CVD ) risk.
OBJECTIVE AND METHOD : The number of tuberculosis ( TB ) deaths in Japan has decreased by @percent@ in the past @number@ years.
Objective and self-assessments were performed at baseline , immediately post training and 5-months after training.
OBJECTIVE : An individual's ability to effectively manage their cancer pain is influenced by knowledge and perceptions regarding the pain experience.
OBJECTIVE : Anthropometric indices to obesity were evaluated as predictors of metabolic syndrome risk factors.
OBJECTIVE : Anti-Müllerian hormone ( AMH ) has been evaluated by several groups as a potential novel clinical marker of ovarian reserve.
OBJECTIVE : Antipsychotic drugs are commonly used to treat behavioural and psychological symptoms of dementia.
OBJECTIVE : Aortic stiffness is an important predictor of future morbidity and mortality.
OBJECTIVE : A patient's risk for anticholinergic adverse effects is frequently estimated by instruments evaluating the drugs included in his medication profile.
OBJECTIVE : A reduced number of circulating endothelial progenitor cells ( EPCs ) are casually associated with the cardiovascular complication of diabetes.
OBJECTIVE : A review of two licensed HPV vaccines ( Gardasil , Merck and Cervarix , GalxoSmithKline ) in the light of these issues.
OBJECTIVE : Arsenic ( As ) exposure may cause several medical problems.
OBJECTIVE : Arterial elasticity decreases with aging.
OBJECTIVE : Arthritis pain and depression are prevalent physical and psychological disorders in late life and co-occur frequently.
OBJECTIVE : Ascertain the incidence of cryptogenic axonal polyneuropathy ( CAP ) and how this relates to the overall incidence of polyneuropathy.
OBJECTIVE : As endometrioma frequently recurs after conservative surgery , long-term postoperative medical treatment for the prevention of recurrence is necessary.
OBJECTIVE : A sequential sputum analysis was conducted to assess the value of SP-A , SP-D and KL-6 levels in COPD.
OBJECTIVE : Assess Aβ deposition longitudinally and explore its relationship with cognition and disease progression.
OBJECTIVE : Assess epidemiological data , trauma mechanism , injury characteristics in hyperostotic spines , and short-term outcome.
OBJECTIVE : Assessing the relationship between happiness and social support networks in Colombia.
OBJECTIVE : Assessment of habitual physical activity ( PA ) in patients with heart failure.
Objective assessment of intranasal dimensions and nasal airflow in all subjects were performed with the use of acoustic rhinometry and active anterior rhinomanometry respectively.
Objective assessments with superimposed 3-D color images showed significant median volumetric reduction of @number@ ml at @number@ months post-treatment.
OBJECTIVE : Assess the association between depressive symptoms ( not meeting the criteria for major depression ) and gait dysfunction in older adults.
OBJECTIVE : assess the effect of a frailty intervention on risk factors for falls and fall rates in frail older people.
OBJECTIVE : Associations of cortisol and depression vary at different life-stages , yet population-based , prospective studies are scarce.
OBJECTIVE : As the most important risk factors of cardiovascular disease , pre-hypertension and hypertension are important public health challenges.
OBJECTIVE : A study was undertaken to relate dietary fat types to cognitive change in healthy community-based elders.
OBJECTIVE : As women age total dietary intake falls which may increase the risk of dietary deficiencies in some individuals.
OBJECTIVE : A systematic review of literature from @number@ to @number@ was conducted using Pubmed and Google Scholar.
OBJECTIVE : Atherosclerosis begins early in life and obesity is a key determinant.
OBJECTIVE : Autophagy is a key pathway of cellular homeostasis for removing damaged macromolecules and organelles , including mitochondria.
OBJECTIVE : Autosomal recessive primary microcephaly ( MCPH ) is a rare condition characterized by a reduced cerebral cortex accompanied with intellectual disability.
OBJECTIVE : Available clinical data raise the possibility that stress-adaptive mechanisms differ by gender.
OBJECTIVE : Baastrup disease is characterized by the development of abnormal contact between adjacent spinous processes.
OBJECTIVE : Bariatric surgery is associated with improved cognitive function , although the mechanisms are unclear.
OBJECTIVE : Because the cancer population is aging , interprofessional education incorporating geriatric principles is essential to providing adequate training for oncology fellows.
OBJECTIVE : Benzodiazepines ( BZDs ) are the most commonly prescribed compounds in insomnia.
OBJECTIVE : Beyond age , having a family history is the most significant risk factor for Alzheimer disease ( AD ) .
OBJECTIVE : Blood endothelial progenitor cells ( EPCs ) and endothelial microparticles ( EMPs ) have been proposed as markers of endothelial dysfunction.
OBJECTIVE : Bond strength limitations of adhesive zirconia restorations have stood as a barrier against their widespread use.
OBJECTIVE : Bone density is distributed in a complex network of interconnecting trabecular plates and rods that are interspersed with bone marrow.
OBJECTIVE : Both adverse social environments and genetic factors contribute to loneliness in old age.
OBJECTIVE : Both the prevalence and incidence of HIV infection among older adults are on the rise.
OBJECTIVE : Brachial pulse pressure ( PP ) is a marker of arterial stiffness in the elderly and a useful tool for measuring vascular aging.
OBJECTIVE : Brain arteriovenous malformations ( AVMs ) are the most common cause of nontraumatic intracerebral hemorrhage in young adults.
OBJECTIVE : Brain damage within the right middle cerebral artery ( MCA ) territory is particularly disruptive to mediolateral postural stabilization.
OBJECTIVE : Brain tissue integrity is highly heritable , and its decline is a common phenomenon of ageing.
OBJECTIVE : Breast cancer is one of the most common cancers in women , particularly among older women.
OBJECTIVE : Breast cancer screening guidelines recommend that women and physicians consider life expectancy when making screening decisions in older women.
OBJECTIVE : Brown adipose tissue ( BAT ) has been proposed as a potential therapeutic target against obesity and its related metabolic conditions.
OBJECTIVE : Calorie restriction and intermittent fasting are two dietary interventions that can improve aging.
OBJECTIVE : Cardiovascular risk factors in middle-age are associated with cognitive impairment and dementia in older age.
OBJECTIVE : Caregivers usually are not involved while planning the stroke survivor's medical and rehabilitation goals and interventions.
OBJECTIVE : Cerebral microvascular disease associated with type @number@ diabetes may exacerbate the effects of aging on cognitive function.
OBJECTIVE : - Characterize the life quality of the elderly swallowing affected by stroke.
OBJECTIVE : China is experiencing a rapid increase in cancer incidence in elderly patients.
OBJECTIVE : Cholecystolithiasis is a common disease in the elderly patient.
OBJECTIVE : Chronic conditions often require multiple medication intake.
OBJECTIVE : Chronic cortisol exposure is hypothesized to contribute to obesity.
OBJECTIVE : Chronic generation of inflammatory cytokines and reactive oxygen species are implicated in atherosclerosis , aging , cancers , and other chronic diseases.
OBJECTIVE : Chronic inflammation is linked to many chronic conditions.
Objective Chronic kidney disease ( CKD ) is present in patients with nonalcoholic fatty liver disease ( NAFLD ) .
OBJECTIVE : Chronic pain is common in HIV-infected individuals.
OBJECTIVE : Chronological age is commonly used to explain change in sleep.
OBJECTIVE : Circulating IGF1 declines with age , and reduced circulating IGF1 is associated with increased cardiovascular mortality in some but not all studies.
OBJECTIVE : Clinical studies indicate increased risk for depression and anxiety among tinnitus patients.
OBJECTIVE : Clinic-based studies suggest that dementia is diagnosed at older ages in bilinguals compared with monolinguals.
OBJECTIVE : Clinicopathologic phenotypes of dementia with Lewy bodies ( DLB ) and Alzheimer disease ( AD ) often overlap , making discrimination difficult.
Objective : Cognitive aging is commonly associated with a decrease in executive functioning ( EF ) .
OBJECTIVE : Cognitive and functional geriatric assessment may change in acromegaly.
OBJECTIVE : Cognitive deficits are among the strongest predictors of function in individuals with schizophrenia.
OBJECTIVE : Cognitive dysfunction is a core feature of bipolar disorder ( BD ) in both adult and geriatric patients.
OBJECTIVE : Cognitive impairment in heart failure ( HF ) is believed to result from brain hypoperfusion subsequent to cardiac dysfunction.
OBJECTIVE : Cognitive impairment is a key factor that threatens functionality and quality of life in seniors.
OBJECTIVE : Cognitive reserve is associated with a lower risk of dementia , but the extent to which it shapes cognitive aging trajectories remains unclear.
OBJECTIVE : ' Community livability ' is a widely used term that is still under-conceptualized.
OBJECTIVE : Compared with older adults , emerging adults ( 18-29 years old ) entering treatment typically have less severe alcohol use consequences.
OBJECTIVE : Compare subjective reports of both memory and word-finding deficits to clinical diagnosis and objective neuropsychological testing.
OBJECTIVE : Complications occur , and they appear to be more frequent with particulated fillers , polyacrylamide gel and silicone oil.
OBJECTIVE : Conscientious individuals tend to experience a number of health benefits , not the least of which being greater longevity.
OBJECTIVE : Consuming curcumin may benefit health by modulating lipid metabolism and suppressing atherogenesis.
OBJECTIVE : Continuous antipsychotic treatment is important in schizophrenia , and studies have shown that rates of discontinuation are high.
OBJECTIVE : Controversy surrounds appropriate risk factor targets in older adults with diabetes.
OBJECTIVE : Conventional whole-head MEG systems have fixed sensor arrays designed to accommodate most adult heads.
Objective Coronary spasm as well as atherosclerosis plays an important role in the pathogenesis of coronary heart disease.
OBJECTIVE : [ corrected ] To evaluate the efficacy and persistence of SGP-HA for the correction of NLFs for up to @number@ months.
OBJECTIVE : Cross-sectionally and longitudinally relate a vascular risk index to cognitive outcomes among elders free of clinical dementia.
OBJECTIVE : Cross-sectional studies suggest an association between hysterectomy and negative affect.
OBJECTIVE : Data-driven approaches to dietary patterns are under-utilized ; latent class analyses ( LCA ) are particularly rare.
OBJECTIVE : Data on peripheral artery disease in Africa are sparse and limited to urban areas.
OBJECTIVE : Death of a parent in childhood can diminish both the nurturing that promotes healthy development , and household income.
OBJECTIVE : Decompose cognitive change into influences unique to particular cognitive domains , and influences shared across different cognitive domains.
OBJECTIVE : Dehydroepiandrosterone sulfate ( DHEAS ) appears to have a protective effect against depression , but contrasting findings are available.
OBJECTIVE : Delirium superimposed on dementia ( DSD ) is common in many settings.
OBJECTIVE : Delirium superimposed on dementia is common and is associated with adverse outcomes.
OBJECTIVE : Delirium superimposed on dementia is common and potentially distressing for patients , caregivers , and health care staff.
OBJECTIVE : Dementia is common and often undiagnosed.
OBJECTIVE : Depression constitutes a major health problem for older people , in this study defined as people @number@ years of age and older.
OBJECTIVE : Depression is an important health issue in cancer patients.
OBJECTIVE : Depression is associated with poor quality of life , higher healthcare costs , and suicide.
OBJECTIVE : Depression is conceptualized as both a risk factor for and a consequence of elder abuse ; however , current research is equivocal.
OBJECTIVE : Depression might be a prodromal stage of dementia.
OBJECTIVE : Depression relates to vascular disease and is a candidate risk factor for dementia.
OBJECTIVE : Depressive disorders have been associated with increased risk for aging-related diseases , possibly as a consequence of accelerated cellular aging.
OBJECTIVE : Depressive symptoms and physical inactivity are health risks among minority older adults.
OBJECTIVE : Describe changes in the population structure of Colombia's municipalities in relation to internal displacement in response to armed violence.
OBJECTIVE : Describe social goods and services for which hospices assist patients and families and the resources hospices use to do so.
OBJECTIVE : Despite improvements in pediatric brain tumor outcomes , the survivors of childhood brain tumor are burdened by multiple comorbidities.
OBJECTIVE : Despite theoretical advances in our conceptualization of disability , the \ "environment \ " remains a largely unspecified term in disablement models.
OBJECTIVE : Determine if the multidimensional pain-related experience differs between cognitively intact and impaired older adults.
OBJECTIVE : determine physician- and subject-reported onset of onabotulinumtoxinA.
OBJECTIVE : Determine the prevalence of hypogonadism among diabetic and non-diabetic men in Jordan.
OBJECTIVE : Diabetes among older adults causes many complications , including decreased lower-extremity function and physical disability.
OBJECTIVE : Diabetes is a major cause of functional decline among older adults , but the role of glycemic control remains unclear.
OBJECTIVE : Diabetes mellitus is associated with an increased risk of cardiovascular disease ( CVD ) and death.
OBJECTIVE : Diabetic patients with acute coronary syndrome ( ACS ) are at higher risk of poor outcome than are non-diabetic patients with ACS.
OBJECTIVE : Different aspects of diet may be differentially related to body fat distribution.
OBJECTIVE : Directly test a role of Ad36 , or E4orf1 in enhancing cellular glucose uptake in presence of inflammatory cytokines.
OBJECTIVE : Disproportionate growth of musculoskeletal tissue is a major cause of morbidity in both acromegalic ( ACRO ) and GH-deficient ( GHD ) patients.
OBJECTIVE : DNA repair pathways are crucial to prevent accumulation of DNA damage and maintain genomic stability.
OBJECTIVE : Dopamine transporter ( DAT ) density is considered as a marker of pre-synaptic function.
OBJECTIVE : Dopamine transporter ( DAT ) imaging shows age-related decline of ligand binding in the normal striatum , a decline attributed to regulatory changes.
OBJECTIVE : Due to rapid population aging and a tidal wave of dementia , dementia has become an urgent public health issue in China.
OBJECTIVE : During recent decades , the prevalence of metabolic morbidity has increased rapidly in adult Greenlandic Inuit.
OBJECTIVE : Early age at menopause is associated with increased risk of cardiovascular disease , stroke , osteoporosis , and all-cause mortality.
OBJECTIVE : Early arterial wall changes are already present in the apparently healthy , middle-aged population and continuously progress with age.
OBJECTIVE : Early biomarkers of Alzheimer's disease ( AD ) are needed for developing therapeutic interventions.
OBJECTIVE : Early studies have indicated that body fat shifts from peripheral stores to central stores with aging.
OBJECTIVE : Effective monitoring and treatment are needed to address the elevated rates of medical comorbidity among individuals with serious mental illnesses.
OBJECTIVE : Effective strategies are needed to encourage smoking cessation for smokers without an intention to quit.
OBJECTIVE : Elderly with several pathologies are usually treated with many drugs , and are exposed to a majored risk of drug-induced adverse effects.
OBJECTIVE : Elder self-neglect is a common public health issue , but it is unclear to what degree it is associated with cognitive function.
OBJECTIVE : Electroencephalographic ( EEG ) coherence is a parameter that enables evaluation of cerebral connectivity.
OBJECTIVE : Encouraging physical activity is an important public health measure to reduce disability prevalence in the aged.
OBJECTIVE : Endoscopic surgery to the nasopharyngeal portion of the Eustachian tube ( ET ) has been advocated for ET dysfunction.
OBJECTIVE : Epidemiological data reveal that the overall risk for kidney stones disease is lower for women compared to age-matched men.
OBJECTIVE : Epidemiological studies in children and adolescents have revealed short sleep duration as a risk factor for weight gain.
OBJECTIVE : Epidemiological studies suggest a relationship between midlife metabolism and old age cognition.
OBJECTIVE : Episodic and semantic processes are involved in temporality used in daily life.
OBJECTIVE : Estimates of the prevalence of hypothyroidism in unselected populations date from the late 1990s.
OBJECTIVE : Estrogen stimulates pulsatile secretion of GH , via mechanisms that are largely unknown.
OBJECTIVE : Evaluate associations of neighborhood social capital and mobility of older adults.
OBJECTIVE : Evaluate clinical , radiological patterns and prognostic factors of subarachnoid hemorrhage ( SAH ) patients according to age.
OBJECTIVE : Evaluate the complication rate and associated risk factors after cervical spine surgery using a national sample of elderly patients.
OBJECTIVE : Evaluate the quality of POLST decisions.
OBJECTIVE : Evaluate the role of calcium on bone health.
OBJECTIVE : Evaluation of circulating miRNA signatures in male and female subjects with idiopathic and postmenopausal osteoporotic low-traumatic fractures.
OBJECTIVE : Evaluation of efficacy and safety of both products.
Objective evaluation of the reconstructions was carried out using the Cutometer MPA580.
OBJECTIVE : Evidence is emerging that delirium duration is a predictor of long-term cognitive impairment in intensive care unit survivors.
OBJECTIVE : Examine prevalence and level of suicide risk , and its associations with sociodemographic factors and mood disorders.
OBJECTIVE : Examine the association between gait characteristics and walking speed decline in older adults.
OBJECTIVE : Examine the association between multiple psychological factors ( depressive symptoms , trait anxiety , perceived stress ) and subclinical atherosclerosis in older age.
OBJECTIVE : Executive dysfunction may play a key role in the pathophysiology of late-life depression.
OBJECTIVE : Exercise is a cornerstone of diabetes management and the prevention of incident diabetes.
OBJECTIVE : Existing oncology performance status measurements are used to predict chemotherapy toxicity in all patients with cancer , regardless of age.
OBJECTIVE : Experience of stressful life events is associated with risk of depression.
OBJECTIVE : Explore the needs and the degree of satisfaction of Francophone seniors living in a minority socio-linguistic urban community in regards to aging-in-place.
OBJECTIVE : Exploring whether age is a significant factor to achieve industrial production rates and determine its possible consequences.
OBJECTIVE : Exposure to acute and chronic stress can affect learning and memory , but most evidence comes from animal studies or clinical observations.
OBJECTIVE : Facial exercises are a noninvasive alternative to medical approaches to facial rejuvenation.
OBJECTIVE : Fall prevention is a major issue in the ageing society.
OBJECTIVE : Familial amyloid polyneuropathy ( FAP ) is an autosomal dominant form of hereditary amyloidosis.
OBJECTIVE : Fetuin-A is an important player in the enhancement of insulin resistance.
OBJECTIVE : Fever of unknown origin ( FUO ) is a diagnostic challenge.
OBJECTIVE : Few data is available on the nutritional status of old Chinese.
OBJECTIVE : Few studies have examined health anxiety in older adults , and it is unknown which factors account for age-related differences in health anxiety.
OBJECTIVE : Few studies have examined racial differences in potentially inappropriate medication use.
OBJECTIVE : Fibroblast growth factor @number@ ( FGF23 ) is a phosphaturic agent involved in calcium-phosphate homeostasis.
OBJECTIVE : Fibroblast growth factor @number@ ( FGF @number@ ) signaling pathway is crucial to lung development and epithelial reconstruction.
OBJECTIVE : Findings on weight training and waist circumference ( WC ) change are controversial.
OBJECTIVE : Following national trends , Washington State relies heavily on foreign-born workers to provide long-term care.
OBJECTIVE : Food cravings are thought to be the result of conditioning or pairing hunger with consumption of certain foods.
OBJECTIVE : Functional abilities are severely impacted in Alzheimer's disease ( AD ) .
OBJECTIVE : Genomic analyses from blood leukocytes have concluded that mouse injury poorly reflects human trauma at the leukocyte transcriptome.
OBJECTIVE : Genotyping for CYP2D6 has the potential to predict differences in metabolism of nortriptyline.
OBJECTIVE Geriatric patients undergoing lumbar spine surgery have unique needs due to the physiological changes of aging.
OBJECTIVE : Given the impact of recurrent falls in older people , risk evaluation for falling is an important part of geriatric assessment.
OBJECTIVE : Given the increasing number of older people , China has become an aging society.
OBJECTIVE : Growing evidence suggests that angiogenesis might represent a new pathogenic mechanism involved in the progression of Alzheimer's disease ( AD ) .
OBJECTIVE : Hair quality and scalp characteristics are considered to be a significant marker of health.
OBJECTIVE : Having experienced 2-3 births is associated with reduced mortality versus women with < 2 or ≥4 births.
OBJECTIVE : Healthcare and mortality costs of secondhand smoke ( SHS ) exposure at home among non-smokers in California were estimated for the year @number@
OBJECTIVE : Hearing loss associated with aging is common among elderly persons.
OBJECTIVE : Hearing loss is a commonly unmet need among adults with dementia that may exacerbate common dementia-related behavioral symptoms.
OBJECTIVE : Here , we review the multitude of actions of FoxO3 that are relevant to health , and thus healthy ageing and longevity.
Objective High-sensitivity cardiac troponin T ( hs-cTnT ) is widely used for the diagnosis of acute myocardial infarction ( AMI ) .
OBJECTIVE : Hippocampal sclerosis of aging ( HS-Aging ) is a common cause of dementia in older adults.
OBJECTIVE : HIV-positive individuals are at higher risk than healthy persons for aging-related diseases , including myocardial infarction and non-AIDS defining cancers.
OBJECTIVE : Homocysteine can accelerate the senescence of endothelial progenitor cells or endothelial cells ( ECs ) via telomerase inactivation and length shortening.
OBJECTIVE : Hospitalization is a major risk for older adults ; therefore , it is crucial to provide the appropriate treatment during hospitalization.
OBJECTIVE : Hydroxytyrosol ( HT ) , the major olive oil antioxidant polyphenol in cardioprotective Mediterranean diets , is endowed with anti-inflammatory and anti-atherosclerotic activity.
OBJECTIVE : Hypothesis - Differences in age dependent levels of HPA components.
OBJECTIVE : IBS is a common gut disorder of uncertain pathogenesis.
OBJECTIVE : Immune and inflammatory pathways play important roles in the pathogenesis of metabolic disorders.
OBJECTIVE : Impairment in reward processes has been found in individuals with depression and in the aging population.
OBJECTIVE : Impairment in social functioning appears to be common in bipolar disorder , although estimates have been derived largely from self-report measures.
OBJECTIVE : Impairment of physical performance might identify older people at higher risk of dementia over time.
OBJECTIVE : In aging populations , poor handgrip strength has been associated with physical disability and mortality.
OBJECTIVE : In a recent study , we found that Greenlandic Inuit children had a more adverse metabolic profile than Danish children.
OBJECTIVE : In China , the rapid socioeconomic transition and the consequential traditional culture change had significant influences on Chinese older-adult depression.
OBJECTIVE : Increased focus on the quality of health care requires tools and information to address and improve quality.
OBJECTIVE : Increasing evidence has suggested an association between sleep duration and osteoporosis risk , although the results of previous studies have been inconsistent.
OBJECTIVE : Indices of arterial stiffness and aortic pressure are usually assessed by applanation tonometry.
OBJECTIVE : Inflammatory processes are putative mechanisms underlying the detrimental health effects of sedentary behaviour but no long-term prospective data are available.
OBJECTIVE : Informal care is a significant component of the societal resource use and costs in dementia care.
OBJECTIVE : In general , ageing is a risk factor for sensory and motor deterioration , with the rate of decline varying amongst individuals.
OBJECTIVE : In @number@ the Health Council of the Netherlands published an advice on vitamin D supplementation for the elderly.
OBJECTIVE : Institutionalised elderly people at northern latitudes may be at elevated risk for vitamin D deficiency.
OBJECTIVE : Instrumental conditioning of EEG activity ( EEG-IC ) is a promising method for improvement and rehabilitation of cognitive functions.
Objective instrumented assessments of physical functioning that are feasible for home frailty screening have not been adequately developed.
OBJECTIVE : Intensive repetitive musical practice can lead to bilateral cortical reorganization.
OBJECTIVE : Interactive voice response ( IVR ) systems offer great advantages for data collection in large , geographically dispersed samples involving frequent contact.
OBJECTIVE : Interleukin ( IL ) @number@ receptor subunit α regulates lymphocyte activation , which plays an important role in atherosclerosis.
OBJECTIVE : In the elderly , obstructive sleep apnea ( OSA ) is frequently under diagnosed.
OBJECTIVE : In the present study , we investigated the influence of task importance on the magnitude of age differences in event-based prospective memory.
OBJECTIVE : In this research , we explored whether perceptual speed or verbal fluency is more important for buffering age differences in technology ownership.
OBJECTIVE : In this study the relationship of serum PTH levels within the normal range with CVD and abdominal aortic calcifications was investigated.
OBJECTIVE : In this study , we examined whether coronary spastic angina ( CSA ) is associated with insulin resistance.
OBJECTIVE : In this study , we sought to explain the rapid musculoskeletal symptomatology increase in correction officers ( COs ) .
OBJECTIVE : Investigate miRNAs in CSF obtained from living donors as biomarkers for AD.
OBJECTIVE : Investigate the influence of apprehensive gait on activation and cocontraction of lower limb muscles of younger and older female adults.
OBJECTIVE : Investigating the relation between social isolation and cognitive function will allow us to identify components to incorporate into cognitive interventions.
OBJECTIVE : Italian Road Law limits driving while undergoing treatment with certain kinds of medication.
OBJECTIVE : It has been suggested that mitochondrial dysfunction is related to aging and metabolic disorders.
OBJECTIVE : It has been suggested that the extent to which older adults identify with ' old-age ' is associated with greater subjective ill-health.
OBJECTIVE It is generally accepted that cerebrospinal fluid shunts fail most frequently in the first years of life.
OBJECTIVE : It is known that continuous glucose monitoring ( CGM ) systems can lower mean glucose compared with episodic self-monitoring of blood glucose.
OBJECTIVE : It is not fully understood how subjective feelings of psychological distress prognosticate dementia.
OBJECTIVE : It is not known which laboratory indices of muscle mass , strength or quality can distinguish functional performance in healthy middle aged women.
OBJECTIVE : It is unclear how brain growth with age affects electrode position in relation to target for children undergoing deep brain stimulation surgery.
OBJECTIVE : It is unclear how changes in ovarian hormones during the menopausal transition contribute to age-associated arterial stiffening.
OBJECTIVE : It is unclear whether implicit probabilistic learning , the acquisition of regularities without intent or explicit knowledge , declines with healthy aging.
OBJECTIVE : It is unknown whether aging affects predecisional processing , that is , gathering information and evaluating options before making a decision.
OBJECTIVE : Key components in the assessment of a child in the emergency department ( ED ) are their heart and respiratory rates.
OBJECTIVE : Key modalities of integrative medicine known to rejuvenate the mind and body are meditation , yoga , and controlled diet.
OBJECTIVE : Klotho is involved in vascular health.
OBJECTIVE : Knowledge about the impact of cardiovascular disease on cerebral autoregulation and cognition in aging is sparse.
OBJECTIVE : Knowledge of smoking change processes may be enhanced by identifying pathways to stable abstinence.
OBJECTIVE : Kraepelin considered declining course a hallmark of schizophrenia , but others have suggested that outcomes usually stabilize or improve after treatment initiation.
OBJECTIVE : Late-onset hypogonadotropic hypogonadism ( LOH ) is a complex , heterogeneous entity.
OBJECTIVE : Lateral amyotrophic sclerosis ( LAS ) is a very severe neurodegenerative disease with progressive course and terminal respiratory insufficiency.
OBJECTIVE : Lead exposure linked to osteoporosis in women.
OBJECTIVE : Leukocyte telomere length ( LTL ) is a biomarker of cellular aging affected by chronic stress.
OBJECTIVE : Lineage-negative bone marrow cells ( lin- BMCs ) are enriched in endothelial progenitor cells and mediate vascular repair.
OBJECTIVE : Literature available on the pathophysiologic aspects of storage symptoms and of antimuscarinic actions on the bladder was reviewed.
OBJECTIVE : Little is known about factors that may prevent or delay adverse health outcomes in frail older adults.
OBJECTIVE : Little is known about the effect of obesity on inflammatory status in pregnant women.
OBJECTIVE : Little is known about the relationship between family longevity , stress , and CVD in African Americans.
OBJECTIVE : Liver cancer severely threatens public health.
OBJECTIVE : Localization of superior sagittal sinus before craniotomy is very crucial to prevent the complications of surgery.
OBJECTIVE : Locomotor adaptation enables safe , efficient navigation among changing environments.
OBJECTIVE : Longitudinal associations were examined between reproductive hormones and sexual function in older men.
OBJECTIVE : Longitudinal comparisons of neurocognitive functioning often reveal stability or age-related increases in performance among adults under about @number@ years of age.
OBJECTIVE : Long-term studies on patients with impulsive behavior have shown a decrease of symptoms with increasing age.
OBJECTIVE : Low back pain ( LBP ) is little explored in the aging population especially when considering age-relevant and culturally dependent outcomes.
OBJECTIVE : Lower urinary tract symptoms ( LUTS ) are common in aging men and are often associated with erectile dysfunction ( ED ) .
OBJECTIVE : Low-grade intestinal inflammation plays a role in the pathophysiology of IBS.
OBJECTIVE : Low hemoglobin negatively affects health in the elderly , but research about the association with risk for depression is limited.
OBJECTIVE : Low testosterone levels and increased aortic stiffness are predictors of cardiovascular events.
OBJECTIVE Lumbar intervertebral disc degeneration , an age-related process , is a major cause of low-back pain.
Objectively monitored total physical activity decreased after the transition to retirement living ( p = @number@ ) .
Objectively recorded environmental barriers in the exterior surroundings did not compromise out-of-home mobility.
Objectively recorded nighttime VMS correlated with PSG-measured WASO ( rs = @number@ P = @number@ ) .
OBJECTIVE : Magnetic resonance imaging ( MRI ) was used to quantify and compare facial soft tissue loss over time.
OBJECTIVE : Main objective of this study was to examine the relationship between LTL and progenitor cells and their impact on adverse cardiovascular outcomes.
OBJECTIVE : Male hypogonadism is common in the elderly and has been associated with increased risk of mortality.
OBJECTIVE : Malnutrition among older hospital inpatients is common and is associated with poor clinical outcomes.
OBJECTIVE : Malnutrition and sarcopenia in institutions are very common and significantly affect the prognosis.
OBJECTIVE : Many short-term studies indicate that @percent@ weight loss in the obese is enough to induce significant improvements of cardiovascular risk factors.
OBJECTIVE : Masticatory function is an important factor for preservation of general health.
OBJECTIVE : Maternal age at birth of last child has been associated with maternal longevity.
Objective measurement of physical activity using wearable devices such as accelerometers may provide tantalizing new insights into the association between activity and health outcomes.
Objective measurement of SB shows that older adults spend an average of @number@ hr a day sedentary , equating to 65-80% of their waking day.
Objective measurements of activity did not correlate well with patient self-report , which has implications for future studies in this area.
OBJECTIVE : Measuring serum tissue transglutaminase immunoglobulin A ( tTG IgA ) levels is the most widely used screening test for coeliac disease.
OBJECTIVE : Meningiomas are among the most common intracranial tumors , accounting for @percent@ of all tumors of the central nervous system.
OBJECTIVE : Menopausal status may increase cardiovascular disease ( CVD ) risk.
OBJECTIVE : Menopause is defined as the permanent cessation of menses.
OBJECTIVE : Metabolically healthy obesity possibly reflects a transitional stage before the onset of metabolic dysfunction , but few studies have characterised this transition.
OBJECTIVE : Metabolic syndrome ( MetS ) and its components accelerate age-associated increases in arterial stiffness and thickness.
OBJECTIVE : Metabolic syndrome ( MS ) increases the risk of atrial fibrillation ( AF ) .
OBJECTIVE : Metacarpal juxtaarticular bone is altered in rheumatoid arthritis ( RA ) .
OBJECTIVE : MicroRNAs ( miRNAs ) play critical roles in cervical carcinogenesis.
OBJECTIVE : Most studies on older adults ' driving practices have relied on self-reported information.
OBJECTIVE : Motivational aspects , emotional factors , and cognition , all of which require intact cognitive functioning may be essential in sexual functioning.
OBJECTIVE : MUC1 is primarily involved in the protection of epithelial surfaces.
OBJECTIVE : Much of the genetic basis for Alzheimer disease ( AD ) is unexplained.
OBJECTIVE : Much of the mild cognitive impairment ( MCI ) neuroimaging literature has exclusively focused on regions associated with Alzheimer's disease.
OBJECTIVE : Multimodal perception raises the issue of sensory integration.
OBJECTIVE : Multimorbidity is a common problem in the elderly that is significantly associated with higher mortality , increased disability and functional decline.
OBJECTIVE : Muscle loss and metabolic changes occur with disuse [ i.e. bed rest ( BR ) ] .
OBJECTIVE : Natural disasters and rapidly aging populations are chronic problems for societies worldwide.
OBJECTIVE : Near-infrared spectroscopy ( NIRS ) is commonly used to investigate continuous changes of brain activation and has excellent time resolution.
OBJECTIVE : Neurodegeneration is now accepted as a pathologic hallmark of multiple sclerosis ( MS ) .
OBJECTIVE : Neurodegenerative and cerebrovascular conditions are common in old age and are associated with cognitive decline.
OBJECTIVE : Newly developed techniques for understanding brain connectivity have emerged with the application of graph theory-based measures to neuroimaging modalities.
OBJECTIVE : Nonmotor symptoms ( NMSs ) are common in Parkinson disease ( PD ) , affecting patient's quality of life.
OBJECTIVE : Non-valvular atrial fibrillation ( NVAF ) is one common arrhythmia in the elderly.
OBJECTIVE : Novel countermeasures to increase healthcare expenditures should be explored in rapidly aging societies , including Japan.
OBJECTIVE : Numerous studies have examined the association between body mass index ( BMI ) and mortality.
OBJECTIVE : Obesity ( as defined by body mass index ) has not been associated consistently with higher mortality in older adults.
OBJECTIVE : Objective biomarkers for attention-deficit / hyperactivity disorder ( ADHD ) could improve diagnostics or treatment monitoring of this psychiatric disorder.
OBJECTIVE : Octogenarians were excluded from participation in many carotid endarterectomy trials due to the high complication rates observed in past studies.
OBJECTIVE OF PROGRAM : To train physicians wishing to provide COE services.
OBJECTIVE : Older adults are increasingly involved in the criminal justice system , yet there is limited research regarding their needs and experiences.
OBJECTIVE : Older adults commonly involve family ( broadly defined ) in their care.
Objective : Older adults frequently report sleep problems and are at increased risk of cardiometabolic disruption.
OBJECTIVE : Older adults often appraise and remember events less negatively than younger adults.
OBJECTIVE : Older couples are likely to be confronted with health problems of both spouses and these health problems may negatively influence their marital satisfaction.
OBJECTIVE : Older driver research has mostly focused on identifying that small proportion of older drivers who are unsafe.
OBJECTIVE : Older people with reduced respiratory muscle strength may be misclassified as having COPD on the basis of spirometric results.
OBJECTIVE : Older people with type @number@ diabetes are at high risk of mobility disability.
OBJECTIVE : Older veterans are the largest cohort served by the U.S. Department of Veterans Affairs ( VA ) .
OBJECTIVE : Olive oil is the main fat source in the Mediterranean diet and shows a protective role against aging and related diseases.
OBJECTIVE : Optimal glucose homeostasis requires exquisitely precise adaptation of the number of insulin-secreting β-cells in the islets of Langerhans.
OBJECTIVE : Optimum outcome for those with psychosis will necessarily involve treatment with antipsychotic medication.
OBJECTIVE : Oral diseases and conditions are prevalent among older people with dementia and cognitive impairment.
OBJECTIVE : Osteoarthritis ( OA ) is the most common form of arthritis and the leading cause of disability in the elderly.
OBJECTIVE : Osteocalcin is a well-known marker of bone formation.
OBJECTIVE : Osteoporosis and atherosclerosis are the two most common diseases in postmenopausal women.
OBJECTIVE : Our aim was to compare CVD risk in participants in Fukuoka and Framingham.
OBJECTIVE : Our aim was to describe characteristics and utilization of hospice among nursing home and non-nursing home patients.
OBJECTIVE : Our aim was to describe the development of EPEC adaptations and document the dissemination of our curriculum.
OBJECTIVE : Our aim was to determine the association between serum sex steroids and bone microarchitecture assessed by HR-pQCT in men.
OBJECTIVE : Our aim was to examine sex- and age-specific relationships of sleep behaviors with all-cause mortality rates.
OBJECTIVE : Our aim was to examine these lifestyle-cognitive function associations in middle-to-older aged women across time.
OBJECTIVE : Our aim was to explore the perspectives of individuals with MCC using a semistructured interview study.
OBJECTIVE : Our aim was to investigate the association between thyroid function and the risk of MCI and dementia in euthyroid elderly subjects.
OBJECTIVE : Our aim was to investigate the effect of long-term TSH suppression on the cognitive function of elderly patients with DTC.
OBJECTIVE : Our aim was to investigate the relationship between TFT results and all-cause and cardiovascular ( CV ) mortality in aged hospitalized patients.
OBJECTIVE : Our aim was to test the hypothesis that nut consumption is inversely associated with the risk of all-cause mortality.
OBJECTIVE : Our group has developed a bipolar bioimpedance measurement-based method for determining the state of wound healing.
OBJECTIVE : Our objective was to assess markers of ovarian reserve and age as long-term predictors of ovarian function after chemotherapy.
OBJECTIVE : Our objective was to determine whether higher metabolic rates measured by two different methods predict early natural mortality in humans.
OBJECTIVE : Our objective was to examine performance of A1c in comparison with fasting plasma glucose ( FPG ) in diagnosing dysglycemia in older adults.
OBJECTIVE : Our objective was to examine the cross-sectional association of vitamin B-6 status with markers of inflammation and oxidative stress.
OBJECTIVE : Our objective was to examine the effects of a computer-based educational intervention designed for general practitioners ( GPs ) to promote active aging.
OBJECTIVE : Our objective was to investigate clinical and biochemical characteristics associated with IGSF1 deficiency in both sexes.
OBJECTIVE : Our objective was to systematically review the literature to examine the discontinuation of preventive medicines in older people with LLE.
OBJECTIVE : Our study aimed to investigate the association between maternal-perceived psychological stress and fetal telomere length.
OBJECTIVE : Our study's objective was to investigate the association between empirically derived DPs in midlife and HA after @number@ y of follow-up.
Objective Oxidative stress is associated with the progression of chronic liver disease.
OBJECTIVE : Oxidative stress ( OS ) is associated with accelerated aging.
OBJECTIVE : Oxidative stress plays an important role in retinal pigmental epithelium ( RPE ) death during aging and the development of age-related macular degeneration.
OBJECTIVE : Pain is a serious problem for many individuals with cerebral palsy ( CP ) .
OBJECTIVE : Participation in the labour force with a hearing impairment presents a number of challenges.
OBJECTIVE : Pathomechanisms of sedentary behaviour ( SB ) are unclear.
OBJECTIVE : Patient activation questions from a major national Medicare survey are used to highlight characteristics of Medicare beneficiaries with low activation.
OBJECTIVE : Patient-centred care is a term frequently associated with quality health care.
Objective : Patients aged ≥65 years requiring surgery for soft-tissue sarcoma are a concern in an aging society.
OBJECTIVE : Patients with obstructive sleep apnea syndrome exhibit accelerated vascular aging and renal damage.
OBJECTIVE : People aging with HIV might have different health conditions compared with people who seroconverted at older ages.
OBJECTIVE : Perceiving oneself as younger than one's actual age functions as a self-enhancing positive illusion that promotes life satisfaction.
OBJECTIVE : Percutaneous coronary intervention ( PCI ) is the first line of treatment for ST-elevated myocardial infarction ( STEMI ) .
Objective performance data for physical and cognitive function were also collected.
OBJECTIVE : Pericardial fat may increase the risk of cardiovascular disease ( CVD ) by increasing circulating levels of inflammation and hemostasis biomarkers.
OBJECTIVE : Persistent and consistently observed racial disparities in physical functioning likely stem from racial differences in social resources and environmental conditions.
OBJECTIVE : Personality disorders ( PDs ) often remain unrecognized in older adults by doctors in general practice.
OBJECTIVE : Persons with diabetes have accelerated muscle loss compared with their counterparts.
OBJECTIVE : Physical activity is a key factor for healthy ageing , yet many older people lead a sedentary lifestyle.
OBJECTIVE : Physical activity ( PA ) , especially moderate-to-vigorous intensity , could protect older adults from cognitive impairment.
OBJECTIVE : Physical activity ( PhA ) has proven to be a protective factor for normal erectile function.
OBJECTIVE : Physical and sociocognitive lifestyle activities promote aspects of cognitive function in older adults.
OBJECTIVE : Physical function impairments are seen among aging , HIV-infected persons on effective antiretroviral therapy ( ART ) .
Objective physical health did not have a significant association with depression or anxiety.
OBJECTIVE : Polypharmacy is a common cause of xerostomia.
OBJECTIVE : Polysomnographic ( PSG ) studies in mild cognitive impairment ( MCI ) are not conclusive and are limited only to conventional sleep parameters.
OBJECTIVE : Positive self-perceptions of ageing are associated with better health ; however , little is known about the potentially underlying mechanisms.
OBJECTIVE : Posterior cortical atrophy ( PCA ) and logopenic progressive aphasia ( LPA ) are clinical syndromes associated with posterior brain atrophy.
OBJECTIVE : Post-traumatic stress disorder ( PTSD ) is a common psychiatric disorder , which may accelerate aging.
OBJECTIVE : Practical quality-of-life ( QOL ) screening methods are needed to help focus clinical decision-making on what matters to individuals with disabilities.
OBJECTIVE : Precise data are lacking concerning laparoscopic sacropexy in the elderly population.
OBJECTIVE : Prediabetes patients are likely to develop type @number@ diabetes ( T2DM ) .
OBJECTIVE : Prefrail and frail older adults are a heterogeneous population.
OBJECTIVE : Prehabilitation consists in providing a repetitive physical exercise before surgery to improve the postoperative recovery course.
OBJECTIVE : Preterm infants are at risk of developing insulin resistance.
OBJECTIVE : Prevention of frail skin is important in older people because frail skin is associated with a risk of injury in this population.
OBJECTIVE : Previous research has revealed poor oral hygiene and health among older people suffering from dementia.
OBJECTIVE : previous studies have demonstrated an association between cytomegalovirus ( CMV ) infection and mortality in adults.
OBJECTIVE : Prior literature has identified inconsistent longitudinal associations between total cholesterol and cognitive decline.
OBJECTIVE : Prior work shows that discrimination is associated with a wide array of negative health outcomes.
OBJECTIVE : Prolonged human immunodeficiency virus-1 ( HIV-1 ) infection leads to neurological debilitation , including motor dysfunction and frank dementia.
OBJECTIVE : Prospective monitoring of posttraumatic amnesia ( PTA ) is recommended following moderate to severe traumatic brain injury ( TBI ) .
OBJECTIVE : Provide an overview of how care needs in permanent residential aged care differ by dementia status.
OBJECTIVE : Ptosis of the submandibular glands is a well-recognized yet poorly quantified element of the aging face and neck.
Objective quantification of such clinically relevant gait changes is necessary to determine fall risk.
OBJECTIVE : Quantitative analysis of the activities of all masticatory muscles is required to elucidate the mechanism of stomatognathic dysfunction.
Objective reasons are given for experimenters to choose between these and other methods of evaluating the nociceptive sensitivity of laboratory animals.
OBJECTIVE : Recent advances suggest that precancerous lesions of pelvic serous carcinoma ( PSC ) originate from tubal secretory cells.
OBJECTIVE : Recently , the role of β-blockers ( BBs ) in reducing perioperative mortality has been challenged.
OBJECTIVE : Recent observations showed that long chain omega @number@ polyunsaturated fatty acids ( n-3 LCPUFA ) could represent a potential treatment for elderly depression.
OBJECTIVE : Recent studies suggest a close local link between bone marrow adiposity and endosteal bone formation.
OBJECTIVE : Recent studies suggest antinuclear antibodies ( ANA ) may be related to mortality risk , but evidence is sparse and inconclusive.
OBJECTIVE : Recent studies suggest that ovarian volume and antral follicle counts ( AFCs ) may be useful indicators of menopause status.
OBJECTIVE : Reductions on the clearance from plasma of chylomicrons are associated with atherosclerosis.
Objective refractions and axial lengths were also recorded.
OBJECTIVE : Regular physical activity ( PA ) is important for maintaining long-term physical , cognitive , and emotional health.
OBJECTIVE : Rehabilitation has been reported to improve pain and disability for patients after lumbar surgery.
OBJECTIVE : Reminiscence therapy is a psychological intervention which is specifically designed to address issues of particular relevance to older adults , such as depression.
OBJECTIVE : Reproductive hormone levels are associated with body size , and the association between estradiol and body size varies over the menopausal transition.
OBJECTIVE : Research on late-middle-aged and older adults has focused primarily on average level of alcohol consumption , overlooking variability in underlying drinking patterns.
OBJECTIVE : Research on the impact of natural disasters on the mental health of older adults finds both vulnerabilities and resilience.
OBJECTIVE : Research suggests that self-esteem can decline in older adulthood.
Objective response was evaluated according to RECIST criteria ; radical hysterectomy and pelvic ± aortic lymphadenectomy was attempted in patients achieving response or stable disease.
OBJECTIVE : Resting heart rate ( RHR ) possibly has a hereditary component and is associated with longevity.
OBJECTIVE : Retirement confidence is a key social barometer.
OBJECTIVE : Reverse phenotypic and functional senescence of hCPCs by ex vivo modification with Pim-1.
Objectives.
OBJECTIVES : A better understanding of the essential components of frailty is important for future developments of management strategies.
OBJECTIVES : Abnormally high glucose levels ( dysglycemia ) increase with age.
OBJECTIVES : According to most existing models , a computer is usually needed for predicting stroke outcome.
OBJECTIVES : Across the developed world , wait lists for facility-based long-term care ( LTC ) beds continue to grow.
OBJECTIVES : Active ageing , considered from the perspective of participation in leisure activities , promotes life satisfaction and personal well-being.
OBJECTIVES : Acute chest pain ( ACP ) is a leading cause of hospital emergency unit consultation.
OBJECTIVES : A descriptive tool or validated scale of consciousness is desirable in infants to test the value of any depth of anesthesia monitor.
OBJECTIVES : Adults hold negative attitudes toward sexual expression in late life.
OBJECTIVES : African-Americans have a higher prevalence of hypertension compared with whites , possibly due to elevated oxidative stress and subsequent vascular dysfunction.
OBJECTIVES : After active antiretroviral therapy , children with HIV are clinically well , whereas psychosocial issues continue to influence their quality of life.
OBJECTIVES : A gait disorder is not an inevitable consequence of aging.
OBJECTIVES : Age-at-menopause and leukocyte telomere length ( LTL ) are both associated with biologic aging.
OBJECTIVES : Ageing has been associated with increasing multimorbidity.
OBJECTIVES : Age-related arterial stiffening and reduction of arterial elasticity are attenuated in individuals with high levels of cardiorespiratory fitness.
OBJECTIVES : Age-related changes are common in many tissues and organs.
OBJECTIVES : Aging , as a stage of development is marked by major changes to which the subject must adapt.
OBJECTIVES : Aging is a rising phenomenon globally and elder abuse is becoming increasingly recognized as a health and social problem.
OBJECTIVES : Aging is associated with changes in resting energy expenditure ( REE ) and body composition.
OBJECTIVES : Aging is associated with declines in executive function and episodic memory.
OBJECTIVES : Aging is the process which unavoidably alters structure and function of the basal membranes in humans.
OBJECTIVES : A loss of speech intelligibility at high presentation levels is called rollover.
OBJECTIVES : Although empathy is a well-established motivation in younger adults for helping others , it is not known whether this extends to aging.
OBJECTIVES : Although the breast cancer incidence in Portugal is lower than the European average , it is the most frequent cancer in women.
OBJECTIVES : Although theorists acknowledge that beliefs about emotions may play a role in age-related emotion behavior , no research has explored these beliefs.
OBJECTIVES : Ambient air pollution has been associated with sudden deaths , some of which are likely due to ventricular arrhythmias.
OBJECTIVES : Anger is a common feeling among family caregivers of elderly dependents.
OBJECTIVES : An RCT of a health promotion and preventive care intervention was done in 2001-2002.
OBJECTIVES : Antibiotic stewardship has been called for across all sites of health care , including nursing homes ( NHs ) .
Objectives : Anti-carbamylated protein ( anti-CarP ) antibodies are detected in RA patients.
OBJECTIVES : An up-to-date overview of the so far identified mechanisms of action of spermidine and other polyamines on aging is presented.
OBJECTIVES : Anxiety and depression are major health problems for carers of frail older people.
OBJECTIVES : Anxiety is a risk factor for cardiovascular disease ( CVD ) and is associated with neurocognitive outcomes.
OBJECTIVES : Aortic geometry changes throughout life are not well defined.
OBJECTIVES : A paucity of research has examined the relationship between addressing the spiritual needs of hospitalized Asians and their overall satisfaction with service provision.
OBJECTIVE : Sarcopenic obesity ( SO ) is associated with poorer physical outcomes and functional status in the older adult.
OBJECTIVES : Around @percent@ of diabetic men have lowered testosterone and symptoms of hypogonadism but the prevalence of hypogonadism among prediabetic men is unknown.
OBJECTIVES : As outdoor workers , seafarers have high levels of work-related exposure to UV radiation.
OBJECTIVES : Aspergillus fumigatus is the most common agent of invasive aspergillosis ( IA ) .
OBJECTIVES : Assess the effectiveness of anticonvulsants for the management of post spinal cord injury ( SCI ) neuropathic pain.
OBJECTIVES : Atrial fibrillation ( AF ) is associated with higher health care costs.
OBJECTIVES : A virtual-reality training program has been developed to help older pedestrians make safer street-crossing decisions in two-way traffic situations.
OBJECTIVES : Barriers to food intake ( FI ) exist in hospital that could exacerbate insufficient FI and malnutrition.
OBJECTIVES : Because of their structural , anti-inflammatory and antithrombic properties , long-chain n-3 fatty acids may be key factors in the aging process.
OBJECTIVES : Behavioral and psychological symptoms of dementia ( BPSD ) cause significant stress and distress to both aged-care residents and staff.
OBJECTIVES : Behavioral factors , including protein intake , influence the quantity and quality of skeletal muscle.
OBJECTIVES : Biological and environmental factors are thought to contribute to the development of cognitive decline ( CD ) .
Objectives : Bisexual older adults are a growing yet largely invisible , underserved , and understudied population.
OBJECTIVES : Blood haemoglobin ( Hb ) concentration declines in elderly men , whilst the level of the adipocyte-derived protein adiponectin increases with age.
OBJECTIVES : Blood or dietary polyunsaturated fatty acids ( PUFAs ) , particularly ω3-PUFAs were known for cardiovascular protective effect.
OBJECTIVES : Bone remodelling is highly inhibited within the otic capsule compared with the rest of the skeleton.
OBJECTIVES : Both aging and hypertension are significant risk factors for heart failure in the elderly.
OBJECTIVES : Both genetic and lifestyle factors have been shown to influence bone mineral density ( BMD ) .
OBJECTIVES : Both physical functioning and cognitive abilities are important for well-being , not least in old age.
OBJECTIVES : Cancellation of elective surgical procedures is inconvenient and stressful on patients , causing loss of working days and disruption of daily life.
OBJECTIVES : Care of patients with dementia raises challenging ethical issues , including the use of deception in clinical practice.
OBJECTIVES : Caring for a family member with Alzheimer's disease is associated with increased burden and depression.
OBJECTIVES : Cerebral malaria ( CM ) is the most lethal form of malaria , yet its pathogenesis is not fully understood.
OBJECTIVES : Changes in estrogen receptor ( ER ) expression likely underlie differential metabolic effects of estrogen in pre- and postmenopausal women.
OBJECTIVES : Changes in health following retirement are poorly understood.
OBJECTIVES : Chronic conditions are pervasive among middle-aged and older adults.
OBJECTIVES : Chronic diseases are important predictors of self-rated health ( SRH ) .
Objectives Chronic kidney disease ( CKD ) has been identified as a significant risk factor for poor post-surgical outcomes.
OBJECTIVES : Chronic renal failure is very common , affecting 30%-40% of community-dwelling elderly.
OBJECTIVES : Chronic stress from experiencing discrimination can lead to long-term changes in psychological and physiologic responses , including shorter leukocyte telomere length.
OBJECTIVES : Clinical predictors of falls in patients with Parkinson disease ( PD ) are fairly inaccurate.
OBJECTIVES : Cochlear implants have been used for many years for bilateral profound hearing loss.
OBJECTIVES : Cognitive decline is often associated with the aging process.
OBJECTIVES : Cognitive declines are common in older people and can be a major health issue in an aging world.
OBJECTIVES : Cognitive dysfunction is prevalent in older adults with bipolar disorder ( BD ) .
OBJECTIVES : Cognitive impairment remains frequent in HIV , despite combination antiretroviral therapy ( cART ) .
OBJECTIVES : Cognitive processing plays an important role in balance and gait and is a contributing factor to falls in older adults.
OBJECTIVES : Community viral load ( CVL ) estimates vary based on analytic methods.
OBJECTIVES : Computer-aided technologies can help to minimize clinical complications of zirconia-based restorations such as veneering porcelain fractures.
OBJECTIVES : Concerns about falling , or fear of falling , is highly common in old age and has adverse consequences.
OBJECTIVES : Conflicting results have been reported regarding the association between white matter lesions ( WML ) and cognitive impairment.
OBJECTIVES : Conservation of Resources ( COR ) theory postulates that individuals utilize various resources to manage stressful circumstances.
OBJECTIVES : Consumption of nuts and seeds is associated favorably with all-cause mortality.
OBJECTIVES : Contradictory results have been found for the impact of therapist's adherence and competence on intervention outcomes.
OBJECTIVES : Controlling blood pressure is a key step in reducing cardiovascular mortality in older adults.
OBJECTIVES : Conventionally , existing information on elder abuse has been institution based , professionally driven , and in high-income countries.
OBJECTIVES : Coresidence is one way that middle-aged offspring assist vulnerable , aging parents.
OBJECTIVES : CT Colonography ( CTC ) is being increasingly used for the radiological evaluation of colorectal symptoms.
OBJECTIVES : Decision aids are effective to improve decision-making , yet they are rarely tested in nursing homes ( NHs ) .
OBJECTIVES : Declining muscle mass and function are hallmarks of the aging process.
OBJECTIVES : Decreased energy intake in older persons poses these people at risk of progressive weight loss.
OBJECTIVES : Delirium severity is independently associated with longer hospital stays , nursing home placement , and death in patients outside the ICU.
OBJECTIVES : Dementia increasingly diminishes the ability to communicate.
OBJECTIVES : Dementia is a progressive condition , affecting increasing numbers of people , characterised by cognitive decline.
OBJECTIVES : Depression and anxiety related to stroke are caused by vascular lesions and psychological reactions.
OBJECTIVES : Depression and cognitive impairment are highly prevalent in later life and frequently co-occur.
OBJECTIVES : Depression in dementia is common , but the prevalence rates differ according to the populations studied and which diagnostic tools are being used.
OBJECTIVES : Depression in later life poses a grave challenge for the aging countries.
OBJECTIVES : Depression in the elderly might represent a prodromal phase of Alzheimer disease ( AD ) .
OBJECTIVES : Depressive symptoms are common in older people ; most previous research on elderly depression focused on individual-level characteristics or neighborhood socioeconomic status.
OBJECTIVES : Despite safety warnings on serious adverse effects and guidance advising discontinuation , antipsychotic use in nursing homes remains high.
OBJECTIVES : Despite the increasing number of lesbian and gay older adults , research geared towards health and well-being of this population is limited.
OBJECTIVES : Despite the rapidly increasing prevalence of cohabitation among older adults , the caregiving literature has exclusively focused on formally married individuals.
OBJECTIVES : Determine diagnostic accuracy of a clinical diagnosis of Parkinson disease ( PD ) using neuropathologic diagnosis as the gold standard.
OBJECTIVES : Dietary fibre reduces body weight and inflammation both of which are linked with knee osteoarthritis ( OA ) .
OBJECTIVES : Disability in older age has been related to several psychosocial characteristics , including social networks , social engagement , and depression.
OBJECTIVES : Discrepant findings of age-related effects between cross-sectional and longitudinal studies on executive function ( EF ) have been described across different studies.
Objectives : Discussions of student debt often overlook the debt parents take on to pay for their children's education.
OBJECTIVES : Drug use is a modifiable risk factor for fall-related injuries in older people.
OBJECTIVES : Dry mouth is a condition associated with reduced salivary secretion and is thought to be related to aging.
OBJECTIVES : Due to increasing aging , the epidemiology of VHD may have changed in China.
OBJECTIVES : During the aging process , there is a progressive deficit in the encoding of new information and its retrieval.
OBJECTIVES : Early signs of dementia may raise concerns in family members as to the safety of the affected person when engaged in common activities.
OBJECTIVES : Economic security around retirement age may be an important determinant of psychological and cognitive well-being of older adults.
OBJECTIVES : E-health services are increasingly offered to provide clients with information and a link to healthcare services.
OBJECTIVES : Elderly service work is a labor intensive and emotion demanding occupation.
OBJECTIVE : Self-perception of changes in body fat among HIV + persons is associated with decreased health related quality of life in cross-sectional studies.
OBJECTIVES : Emerging data suggest that HIV disease and its treatment affect the aging process.
OBJECTIVES : Emerging literature suggests that lifestyle factors may play an important role in reducing age-related cognitive decline.
OBJECTIVES : Endothelial progenitor cells ( EPCs ) play an important role in postnatal neovascularization.
OBJECTIVE : Sentencing trends have created a demographic shift in prison populations.
OBJECTIVES : Epidemiological data concerning atherosclerotic disease among older people in rural China are sparse.
OBJECTIVES : Epidemiological studies have shown that molecular mechanisms underlying the development of lung cancers differ between smokers and unsmokers.
OBJECTIVE : Serum insulin-like growth factor @number@ ( IGF-1 ) concentration decreases , while the prevalence of depressive symptoms increases with advancing age.
OBJECTIVES : Estrogen deficiency during menopausal transition is associated with rapid bone loss.
OBJECTIVES : Evaluate the impact of the Geriatric Oncology Consultation on the final therapeutic management of cancer in elderly patients aged @number@ and older.
OBJECTIVE : Several alterations of magnesium metabolism have been associated with type @number@ diabetes pathophysiology , a condition particularly frequent in older persons.
OBJECTIVES : Evidence suggests a predictive association between emotion and mortality risk.
OBJECTIVES : Evidence suggests vitamin D deficiency is associated with developing frailty.
OBJECTIVES : Examines combinations of professionals visited for a serious personal problem.
OBJECTIVES : Excessive shortening of the telomeric ends of chromosomes is a marker of accelerated aging.
OBJECTIVES : Exploratory pilot study to determine the correlation between postmenopausal vulvovaginal symptoms and vaginal cytokine levels.
OBJECTIVES : Falls are a significant problem associated with aging , and can lead to serious consequences including injury and death.
OBJECTIVES : Falls are highly prevalent in individuals with cognitive decline.
OBJECTIVES : Feasibility and efficacy of computerized auditory cognitive training ( ACT ) was examined among patients with heart failure ( HF ) .
Objectives Few epidemiological studies have examined whether associations of psychosocial working conditions with risk of poor health differ by age.
OBJECTIVES : Few studies have explicitly tested whether the health disadvantage among older blacks is consistent across the entire range of education.
OBJECTIVES : Financial decision-making ( FDM ) is crucial for independent living.
OBJECTIVES : Financial strain , defined as inadequate income to cover basic needs , is related to depression in minority populations.
OBJECTIVES : Focal dystonia of the head and neck are associated with a loss of kinesthetic acuity at muscles distant from the dystonic sites.
OBJECTIVES : Folate status and / or genes have been linked to depression in a number of studies.
OBJECTIVES : Functional neuroimaging and voxel-based morphometry studies have confirmed the important role of the cerebellum in motor behavior.
OBJECTIVES : Genomic aneuploidy is a common cause of human genetic disorders.
OBJECTIVES : Growing evidence shows several possible relations between religiousness and late-life depression.
Objectives : Having a role model of successful aging may contribute to views on aging.
OBJECTIVES : Health care system fragmentation is a pervasive problem.
OBJECTIVES : High rates of malnutrition have been reported in the older hospitalized patient population.
OBJECTIVES : Hip fractures are common , morbid , and costly health events that threaten independence and function of older patients.
OBJECTIVES : Hip fractures ( HFs ) in old age frequently cause severe functional impairment and deteriorating autonomy in everyday life.
OBJECTIVES : Homocysteine ( HCY ) is associated with an increased risk for cardiovascular disease , possibly leading to myocardial damage.
OBJECTIVES : Hospitalization in community-dwelling elderly is often accompanied by functional loss , increasing the risk for continued functional decline and future institutionalization.
OBJECTIVES : Human epididymis protein @number@ ( HE4 ) is a tumor marker in diagnosing ovarian cancer.
OBJECTIVES / HYPOTHESIS : Age-related changes in laryngeal muscle structure and function may contribute to deficits in voice and swallowing observed in elderly people.
OBJECTIVES / HYPOTHESIS : Determine if there might be an increase in the workload for head and neck surgery based on an aging population.
OBJECTIVES / HYPOTHESIS : Presbyphonia is common among elderly individuals , yet few studies have evaluated behavioral treatment approaches for presbyphonia.
OBJECTIVES / HYPOTHESIS : The tongue contributes to a safe swallow.
OBJECTIVES / HYPOTHESIS : To assess the influence of factors that can affect postural instability in vestibular neuritis ( VN ) .
OBJECTIVES / HYPOTHESIS : To characterize the histologic and biochemical properties of auricular and septal cartilage and analyze age-related changes in middle-aged to older adults.
OBJECTIVES / HYPOTHESIS : To measure odor detection thresholds and associated nasal and behavioral factors in an older adult population.
OBJECTIVES / HYPOTHESIS : To quantify the prevalence and determine the impact of dizziness and balance disorders in the elderly.
OBJECTIVES / HYPOTHESIS : Verbal fluency deteriorates with normal aging , but is much more severe in Alzheimer's Disease ( AD ) .
OBJECTIVES : Identification of early Alzheimer's disease ( AD ) has become very important.
OBJECTIVES : Identifying factors associated with cognitive limitations among older adults has become a major public health objective.
OBJECTIVES : Impaired arousal signifies underlying brain dysfunction , but its clinical significance outside the intensive care unit remains unclear.
OBJECTIVES : Impulsivity is a construct that is strongly associated with Gambling Disorder ( GD ) .
OBJECTIVES : Inadequate sleep increases the risk for age-related cognitive decline and recent work suggests a possible role of the gut microbiota in this phenomenon.
OBJECTIVES : Incidences of overactive bladder ( OAB ) and cognitive dysfunction increase with aging.
OBJECTIVES : In clinical practice , discrepancies are observed between self and proxy reports of various aspects of Parkinson's disease ( PD ) .
OBJECTIVES : Increasingly , cognitive training appears an asset in improving attention and working memory for older adults.
OBJECTIVES : Increasing numbers of people reach old age.
OBJECTIVES : In current society , an increasing population of older adults and a high prevalence of depressive symptoms in late life is noticeable.
OBJECTIVES : Informal caregiving has been found to be burdensome and is associated with depression among older caregivers.
OBJECTIVES : In Japan , the prevalence of depression has been reported to occur among @number@ in @number@ family caregivers.
OBJECTIVES : In @number@ and @number@ we demonstrated elevated blood harmane concentrations [ HA ] in essential tremor ( ET ) cases.
OBJECTIVES : In older adults , traditional metrics derived from polysomnography ( PSG ) are not well correlated with subjective sleep quality.
OBJECTIVES : In our previous reports , we have demonstrated that extremely low-frequency electromagnetic fields ( ELF-EMF ) exposure enhances the proliferation of keratinocyte.
OBJECTIVES : In the West , self-rated health reliably predicts death , but conceptualizations of health and cause-composition of mortality may be contextually specific.
OBJECTIVES : In this essay , we map out key driving forces that will shape environmental epidemiology in the next 25years.
OBJECTIVES : In this study , we advance knowledge about activity engagement by considering many activities simultaneously to identify profiles of activity among older adults.
OBJECTIVES : In this study we evaluated the associated conditions and demographic data of the patients who have hip fractures.
OBJECTIVES : In this study , we examined whether the association between particulate air pollution and DNA methylation differs across quantiles of the methylation distribution.
OBJECTIVES : Intraindividual variability ( IIV ) in reaction time refers to the trial-to-trial fluctuations in responding across a given cognitive task.
OBJECTIVES : Intrusive thoughts and images are common across the adult lifespan , but vary in their consequences.
OBJECTIVES : Investigate associations of diffuse idiopathic skeletal hyperostosis ( DISH ) with self-reported and measured physical function in older adults.
OBJECTIVES : Investigate the level of measurement invariance of the KOP-Q between the Netherlands and United States of America ( USA ) .
OBJECTIVES : Investigate whether bipolar disorder ( BD ) and its clinical specificities are associated with telomere shortening.
OBJECTIVES : Investigating whether cognitive functioning is associated with the perception of one's sexuality in old age.
OBJECTIVES : It has been suggested that exercise improves cognitive function and increases cerebral volume even in older people.
OBJECTIVES : It is commonplace for people to complain about being tired.
OBJECTIVES : It is known that self-reported health ( SRH ) declines with increasing age and that comorbidity increases with age.
OBJECTIVE : Skeletal muscle protein metabolism is resistant to the anabolic action of insulin in healthy , nondiabetic older adults.
OBJECTIVES : Klotho deficiency has been previously linked to aging-like phenotypes such as osteoporosis , cognitive impairment , and sarcopenia.
OBJECTIVES : Knee height has been commonly used to estimate stature but may not always be possible in the frail older adults with compromised posture.
OBJECTIVES : Large tooth substance losses are frequent in posterior teeth because of primary caries or aging restorations.
OBJECTIVES : Later life is often accompanied by experiences of loss and bereavement in several life domains.
OBJECTIVE : Sleep duration is known to significantly affect health in adults and children , but little is understood about long-term associations.
Objective sleep efficiency emerged as the strongest correlate of subjective sleep quality across all models , and across both sexes.
OBJECTIVE : Sleep problems are associated with mortality in Western populations.
OBJECTIVE : Sleep problems are prevalent among older adults who are at risk of developing dementia.
OBJECTIVE : Sleep problems may adversely affect neuronal health.
OBJECTIVES : Leisure-time physical activity ( PA ) has been established to be related to more years lived without disability.
OBJECTIVES : Leucine-rich milk and whey proteins have been suggested for prevention of age related loss of muscle mass and strength i.e. sarcopenia.
OBJECTIVES : Life review can be implemented within a group as well as on an individual level.
OBJECTIVES : Limited health literacy has been shown to be associated with poor health status.
OBJECTIVES : Little information exists on the frequency and determinants of drug-associated long QT syndrome in older adults.
OBJECTIVES : Little is known about how exposure to a combination of infectious and chronic conditions throughout the lifecourse could impact disability in old age.
OBJECTIVES : Little is known about how lithium should be dosed to achieve therapeutic but safe serum concentrations in older adults.
OBJECTIVES : Little is known about influences of sample selection on estimation in propensity score matching.
OBJECTIVES : Little is known about socio-economic differences in dietary intake among older adults.
OBJECTIVES : Little is known about the very long-term cognitive outcome in patients with childhood-onset epilepsy.
OBJECTIVES : Living alone in later life is an important risk factor of loneliness for elderly people unless they have resources to compensate for that.
OBJECTIVES : Longitudinal biomeasures of health are still new in nationally representative social science survey research.
OBJECTIVES : Long-term lower motor neuron denervation of skeletal muscle is known to result in degeneration of muscle with replacement by adipose and fibrotic tissues.
OBJECTIVES : • Low testosterone levels have been related to a higher diagnosis of prostate cancer ( PCa ) .
OBJECTIVES : Low thiopurine S-methyltransferase ( TPMT ) enzyme activity is associated with increased thiopurine drug toxicity , particularly myelotoxicity.
OBJECTIVES : Lutein and zeaxanthin are dietary carotenoids that preferentially accumulate in the macular region of the retina.
OBJECTIVES : Malnutrition and functional decline are common in older inpatients admitted to subacute care settings.
OBJECTIVES : Many reports exist of the cardiovascular toxicity of smoked cannabis but none of arterial stiffness measures or vascular age ( VA ) .
OBJECTIVES : Many studies investigated serum UA levels in AD patients , but to date , results from these observational studies are conflicting.
OBJECTIVES : Masked hypertension is associated with metabolic risks and increased risk of cardiovascular disease.
OBJECTIVES : Mechanically ventilated critically ill patients receive significant amounts of sedatives and analgesics that increase their risk of developing coma and delirium.
OBJECTIVES : Memory clinics ( MCs ) are multidisciplinary teams involved with early diagnosis and treatment of people with dementia.
OBJECTIVES : Mental health care for older people is primarily delivered in the community and is largely dependent on informal carers.
OBJECTIVES : Microvascular changes may represent an underlying mechanism through which overweight contributes to cardiovascular disease development.
OBJECTIVES : Middle-aged adults often provide support to aging parents , but researchers know little about support that young adults provide middle-aged parents.
OBJECTIVES : Midlife to older rural women with prehypertension are at increased risk for hypertension and its impact on cardiovascular health with advancing age.
OBJECTIVES : Mild cognitive impairment ( MCI ) is etiologically heterogeneous , and a substantial proportion of MCI subjects will develop different dementia disorders.
OBJECTIVE : Smoking is the leading preventable cause of death among individuals with mental health difficulties ( MHD ) .
OBJECTIVES : Most people deal with intrusive life events such as cancer and the care trajectory together with their intimate partners.
OBJECTIVES : Most β-blockers may induce weight gain , dysglycemia , and dyslipidemia.
OBJECTIVES : MTHFR C677T and A1298C have been associated with the risk of preeclampsia ( PE ) , but with conflicting results.
OBJECTIVES : Much is known about the factors making caring for a spouse with dementia burdensome.
OBJECTIVES : Multimorbidity , the presence of multiple chronic medical conditions , is particularly prevalent in older adults.
OBJECTIVES : Multitasking is a challenging aspect of human behavior , especially if the concurrently performed tasks are different in nature.
OBJECTIVES : Muscle size decreases in response to short-term limb immobilisation.
OBJECTIVES : Neighborhood socioeconomic status ( SES ) can be associated with depression.
OBJECTIVES : Neuroticism is a broad construct that conveys a predisposition to experience psychological distress and negative mood states.
OBJECTIVES : Normal pressure hydrocephalus ( NPH ) is a treatable neurological syndrome developing in the elderly.
OBJECTIVES : Nurses are at increased risk of occupational asthma , an observation that may be related to disinfectants exposure.
OBJECTIVES : Nursing home ( NH ) hospitalizations place an enormous economic burden on an already overtaxed American healthcare system.
OBJECTIVES : Nutrition plays a central role in health , with poor dietary habits and nutritional intake being associated with a range of chronic diseases.
OBJECTIVES : Obesity prevalence among people living with HIV ( HIV + ) is rising.
OBJECTIVES : Observations of minimal pathophysiological changes in the liver with healthy aging represent the rationale for expanding the donor pool with older donors.
OBJECTIVE : Social capital , the collective resources of groups including perceptions of trust and reciprocity , is recognized as an important contributor to suicide.
OBJECTIVE : Social isolation is a common problem in older people who move into care that has negative consequences for well-being.
OBJECTIVES : Older adults are a population vulnerable to the effects of alcohol , medication-to-alcohol interactions , and combining multiple medications.
OBJECTIVES : Older adults are the fastest growing age group in Australia , necessitating an increase in appropriate mental health services in the coming years.
OBJECTIVES : Older adults complain of sleep disturbances more often than younger adults do.
OBJECTIVES : Older adults die by suicide at a higher rate than any other age group in nearly every country globally.
OBJECTIVES : Older adults often suffer from vitamin D deficiency and from the frailty syndrome charac-terized by different physical limitations , complicating independent everyday life.
OBJECTIVES : Older adults tend to exhibit the correspondence bias to a greater extent than young adults.
OBJECTIVES : Older adults who have experienced traumatic events earlier in life may be especially vulnerable to additional challenges associated with aging.
OBJECTIVES : Older adults with care needs live in a variety of settings-from traditional community housing to nursing homes.
OBJECTIVES : Older adults with sarcopenia and malnutrition are at risk for co-morbidities , hospitalization , institutionalization , and mortality.
Objectives : Older inmates are the fastest growing segment of the prison population ; however , the reasons for this are not well understood.
OBJECTIVES : Older people with intellectual disabilities ( ID ) may experience more and different symptoms of anxiety than older people with normal intelligence.
OBJECTIVES : Olfactory performance plays a vital role in several aspects of everyday life.
OBJECTIVE : Some data suggest that obesity blunts the benefits of exercise on mobility in older adults.
OBJECTIVE : Some dynamometers previously tested in healthy adults showed variable degrees of practicality , weight and ergonomics.
OBJECTIVES : Osteoporosis is a skeletal disorder characterized by impaired bone turnover and compromised bone strength , thereby predisposing to increased risk of fracture.
OBJECTIVES : Our goal was to build a systemic model of chronic use among community-dwelling mature benzodiazepine ( BZD ) users.
OBJECTIVES : Our goal was to describe a single-center's experience in managing acute and chronic mesenteric ischemia with endovascular therapies.
OBJECTIVES : Our objectives were to evaluate and estimate the risk of new-onset diabetes associated with statin exposure in a cohort of elderly Australian women.
OBJECTIVES : Oxidative stress is considered the potential risk to the development of dementia.
OBJECTIVES : Pain is underrecognized and undermanaged in older adults with dementia.
OBJECTIVES : Past work found that close adult attachment dimension scores predict caregiver preparedness.
OBJECTIVES : Patients with dementia experience a wide range of neuropsychiatric symptoms.
OBJECTIVES : Patients with serious mental illness are living longer.
OBJECTIVES : Peaceful Mind , a cognitive-behavioral therapy for treating anxiety in persons with dementia , is a promising new treatment currently under investigation.
OBJECTIVES : Perceived discrimination has been associated with poor physical and psychological health.
OBJECTIVES : Performance of methods used for molecular diagnostics must be closely controlled by regular analysis of internal quality controls.
OBJECTIVES : Permanent fillers differ with respect to composition and chemical and biological characteristics.
OBJECTIVES : Peroxiredoxin @number@ ( Prx @number@ ) is a newly emerging antioxidant protein that has been studied in several human cancers.
OBJECTIVES : Personality factors parsimoniously capture the variation in dispositional characteristics that affect behaviours , but their value in predicting medication non-adherence is unclear.
OBJECTIVES : Personality traits are associated with risk of dementia ; less is known about their association with the trajectory of cognitive functioning.
OBJECTIVES : Person-centered Care ( PCC ) is an innovative approach which seeks to improve the quality of care services given to the care-dependent elderly.
OBJECTIVES : Physical activity-an important determinant of health and function in old age-may vary according to the life-space area reached.
OBJECTIVE : Spirometric Z scores by lambda-mu-sigma ( LMS ) rigorously account for age-related changes in lung function.
OBJECTIVES : Point-of-care cardiac troponin testing with adequate analytical performances has the potential to improve chest pain patients flow in the emergency department.
OBJECTIVE : Spontaneous cervical artery dissection ( CAD ) is a cerebrovascular disease typically considered to affect the young population.
OBJECTIVES : Poor quality of early life conditions has been associated with poorer late life cognition and increased risk of dementia.
OBJECTIVES : Possessions constitute a dynamic \ "material convoy \ " that accumulates across adulthood to furnish role enactments and the development of the self.
OBJECTIVES : Postoperative delirium is a common psychiatric disorder among patients who undergo cardiac surgery.
OBJECTIVES : Pregnancy can increase production of Immunoglobulin E ( IgE ) , an immune response more often directed towards parasite infections.
OBJECTIVES : Presbylaryngis , or aging of the larynx , can adversely affect vocal function and quality of life in the elderly.
OBJECTIVES : Previous research indicates that volunteer satisfaction and enjoyment do not exert direct effects on the cessation of volunteering by older adults.
OBJECTIVES : Previous studies have illustrated the link between high on-aspirin platelet reactivity ( HAPR ) with increasing thrombotic risks.
OBJECTIVES : Previous studies have revealed that memory performance is diminished in chronic pain patients.
OBJECTIVES : Previous studies of older European populations have established that disability and morbidity vary with indicators of socio-economic position ( SEP ) .
OBJECTIVES : Prior integrative reminiscence interventions have had a limited focus on attachment themes.
OBJECTIVES : Prior studies have suggested a relationship between dehydration and poor cognitive performance.
OBJECTIVES : Prior studies of age-restricted samples have demonstrated that , in older adulthood , neuroticism is negatively associated with difficulties performing specific daily activities.
OBJECTIVES : Prior work has examined the shape of the income-mortality association , but work has not compared gradients between countries.
OBJECTIVES : Protective steps are essential for fall avoidance.
OBJECTIVES : Providing care for a family member with dementia is associated with increased risk of adverse mental health sequelae.
OBJECTIVES : Psychological effects of supporting someone with mild cognitive impairment ( MCI ) are often overlooked.
OBJECTIVES : Psychosocial stressors faced by patients with fragile X-associated tremor / ataxia syndrome ( FXTAS ) and their caregivers have not been systematically explored.
OBJECTIVES : Public investment in community health centres ( CHCs ) has been increasing as a response to rapid urbanisation in China.
OBJECTIVES : Purpose : To compare the performance of low muscle mass and function with falls risk , incident fracture and mortality over @number@ years.
OBJECTIVES : Quantitative EEG can monitor changes in brain function during development and may help to understand developmental disorders.
OBJECTIVES : Racial disparities in late-life cognition persist even after accounting for educational attainment.
OBJECTIVES : Recent literature suggests reduced benefits associated with high intensity ( HIT ) and or sustained intensity exercise training ( SIT ) .
OBJECTIVES : Recent research suggests that older listeners may have difficulty processing information related to the fundamental frequency ( F0 ) of voiced speech.
OBJECTIVES : recent studies have reported that hospitals have become a common place of death for nursing home residents.
OBJECTIVES : Research estimates that a significant percentage of individuals with mild cognitive impairment ( MCI ) experience functional difficulties.
OBJECTIVES : Research has increasingly suggested a consistent relationship between peripheral hearing and selected measures of cognition in older adults.
OBJECTIVES : Research has shown that obesity appears to spread through social ties.
OBJECTIVES : Research on age stereotypes suggests that views of older persons are complex and multidimensional.
OBJECTIVES : Research on the health consequences of long-term injection drug use ( IDU ) is limited.
OBJECTIVES : Research on the influence of relationships with grandchildren on older adults ' subjective well-being ( SWB ) has been sparse.
OBJECTIVES : Research shows that socially disadvantaged groups especially African Americans and people of low socioeconomic status ( SES ) experience more unstable social environments.
OBJECTIVES : Research suggests that the strength of the relationship between body image and emotional distress decreases with age.
OBJECTIVES : Resistance exercise is used as a non-pharmacological tool to elicit both gains in and maintenance of physical function in the elderly.
OBJECTIVES : Sarcopenia and visceral obesity have been suggested to aggravate each other , resulting in a vicious cycle.
OBJECTIVES : Sarcopenia is associated with frailty and disability among the elderly and imposes significant costs on health care systems.
OBJECTIVES : Sarcopenia , the involuntary loss of skeletal muscle with age , affects up to one-quarter of older adults.
OBJECTIVES : Self-perceived quality of life ( QOL ) is an important outcome indicator in schizophrenia and a predictor of symptomatic and functional improvement.
OBJECTIVES : Self-rated health , as distinct from objective measures of health , is a clinically informative metric among older adults.
OBJECTIVES : Senescence of the immune system and of endothelial cells can contribute to age-dependent vascular and neurodegenerative disorders including Alzheimer's disease.
OBJECTIVES : Services provided to older people should be developed based on active ageing policies.
OBJECTIVES : Several formulations have been proposed in order to model human growth from birth to maturity.
OBJECTIVES : Several polyphenols from renewable sources were surveyed for dentin biomodification.
OBJECTIVES : Several studies have highlighted a link between vascular alterations and cognitive decline.
OBJECTIVES : Severe hypoglycemia is associated with cognitive decline and dementia in older persons with type @number@ diabetes.
OBJECTIVES : Sex hormones affect physical , mental , and social health , yet their role in mediating social effects on aging is understudied.
OBJECTIVES : Similarity to the self has been shown to affect memory for impressions in younger adults , suggesting a self-reference effect in person memory.
OBJECTIVES : Skeletal age estimation is an integral part of the biological profile.
OBJECTIVES : Sleep apnea poses an elevated risk for chronic age-related diseases.
OBJECTIVES : Sleep comprises one-third of one's life , yet little is known about sleep in developing countries.
OBJECTIVES : Sleep deprivation can physically affect skin appearance , e.g. increase the cutaneous signs of aging.
OBJECTIVES : Sleep disturbance and aging are associated with increases in inflammation , as well as increased risk of infectious disease.
OBJECTIVES : Sleep disturbance is a common comorbidity of chronic pain.
OBJECTIVES : Sleep interruption is often reported by women with hot flashes and night sweats ( or vasomotor symptoms , VMS ) .
OBJECTIVES : Social activities such as ' eating-with-others ' can positively affect the ageing process.
Objectives : Social scientists need practical methods for harnessing large , publicly available datasets that inform the social context of aging.
OBJECTIVES : Some of the major challenges associated with successful dietary weight management include the identification of individuals not responsive to specific interventions.
OBJECTIVES : Spinal meningiomas mainly occur in old patients , with a remarkable female prevalence.
OBJECTIVES : Spousal support within marriage may be particularly important in old age when spouses become more likely to rely on each other's help.
OBJECTIVES : Stereotype threat can impair older adults ' performance on clinical assessments for cognitive decline.
OBJECTIVES : Stroke survivors experience poor oral health when discharged from the hospital to the community.
OBJECTIVES : Studies demonstrate associations between changes in obesity-related phenotypes and cardiovascular risk.
OBJECTIVES : Studies in cognitive aging demonstrated inconsistent association between hearing and cognition in older adults.
OBJECTIVES : Studies on implementation techniques that focus on nutrition in the setting of elderly care are scarce.
OBJECTIVES : Study formal and informal care of community-living older people in the Swedish National study of Aging and Care ( SNAC ) .
OBJECTIVES : Subjects with depression might request more healthcare services.
OBJECTIVES : Substantial evidence indicates that depressed participants perform more poorly than nondepressed participants on a number of memory tasks.
OBJECTIVES : Subtle deficits in visual selective attention have been found in amnestic mild cognitive impairment ( aMCI ) .
OBJECTIVES : Successful aging continues to be applied in a variety of contexts and is defined using a number of different constructs.
OBJECTIVES : Suicidal behavior ( SB ) is a major cause of mortality for patients diagnosed with bipolar disorder ( BD ) .
OBJECTIVES : Suicide among older adults is a major public health problem in the USA.
OBJECTIVES : Suicide among the elderly is a dramatic global health problem.
OBJECTIVES : Suicide is a prevalent problem in older adults.
OBJECTIVES : Technology represents advances in knowledge that change the way humans perform tasks.
OBJECTIVES : Testosterone deficiency syndrome ( TDS ) is common among male patients with chronic kidney disease ( CKD ) .
OBJECTIVES : The ageing population implicates an increasing numbers of older adults attending Emergency Departments ( ED ) .
OBJECTIVES : The aim of the current study was to develop sex and age-adjusted criterion-referenced fitness standards to predict independent physical functioning into later life.
OBJECTIVES : The aim of the study was to assess inappropriate antihypertensive prescriptions to older patients.
OBJECTIVES : The aim of this article was to identify the best predictors of distress suffered by family carers ( FCs ) of geriatric patients.
OBJECTIVES : The aim of this long-term retrospective study was to compare the clinical features of elderly and younger polymyositis patients.
OBJECTIVES : The aim of this qualitative study was to analyse in which form and under which conditions such information offices are run.
OBJECTIVES : The aim of this research is to compare subjective and objective methods on the estimate of the consumption of sodium.
OBJECTIVES : The aim of this study is to examine the relative contribution of functional impairment and cognitive deficits on risk of hospitalization and costs.
OBJECTIVES : The aim of this study was to assess the influence of age on pulp response time and on pain intensity.
OBJECTIVES : The aim of this study was to describe new mutations of COL7A1 in patients with DEB and ACC and investigate possible genotype-phenotype correlations.
Objectives The aim of this study was to determine the prospective association of cumulative mechanical exposure during working life with health-related labor market outcomes.
OBJECTIVES : The aim of this study was to evaluate the 1-y survival of elderly patients with cancer and the association between undernutrition and mortality.
OBJECTIVES : The aim of this study was to evaluate the effects of aging on nasal tactile sensitivity.
OBJECTIVES : The aim of this study was to examine the attrition rate and predictors of attrition in a Web-based intervention study on alcohol consumption.
OBJECTIVES : The aim of this study was to explore the attitudes of older people living in institutions and their caregivers to ageing.
OBJECTIVES : The aim of this study was to identify barriers and enablers that may influence a patient's decision to cease a medication.
OBJECTIVES : The aim of this study was to investigate changes in the nasal cycle with age.
OBJECTIVES : The aim of this study was to investigate the effects of guar gum on postprandial blood pressure in older people.
OBJECTIVES : The aims of this cross-sectional study were to examine nutritional status , the use of medications , and drug-nutrient interactions in older adults.
OBJECTIVES : The aims of this study were to examine associations of discharge heart rate with outcomes in hospitalized patients with HFpEF.
OBJECTIVES : The ApolipoproteinE epsilon4 ( APOE epsilon4 ) allele influences cognitive decline ( CD ) in some but not in all individuals.
OBJECTIVES : The article approaches stress from a generational perspective asking : which are the stressors the baby boomer generation is facing ?
OBJECTIVES : The association between weight change and cognition is controversial.
OBJECTIVES : The association of alcohol consumption with performance in different cognitive domains has not been well studied.
OBJECTIVES : The associations between nutritional status and lifestyle factors have not been well established.
OBJECTIVES : The author describes a technical refinement wherein diluted hyaluronic acid ( HA ) fillers are injected into the temple.
OBJECTIVES : The authors assess the safety and efficacy of laser-assisted transdermal delivery of topical anesthetic.
OBJECTIVES : The authors described techniques for fat compartment and potential space volumization of the midface via a standardized and reproducible technique.
OBJECTIVES : The authors describe their results with Endotine brow fixation for browlift through a TBBL approach.
OBJECTIVES : The authors establish normal values for eyelid anthropometry in an Indian population.
OBJECTIVES : The authors had for aim to assess the inter- and intra-individual variability of teicoplanin pharmacokinetic parameters in geriatric patients.
OBJECTIVES : The authors investigated the changes in resting Pd / Pa and iFR according to anatomic and hemodynamic stenosis severity and their prognostic implications.
OBJECTIVES : The authors investigate the application and outcomes of ablative fractional technology in a private cosmetic surgery practice.
OBJECTIVES : The authors investigate whether facial wrinkles are related to underlying lymphatic vessels and perilymphatic fat.
OBJECTIVES : The authors review the evidence of the effectiveness of facial exercises for facial rejuvenation.
OBJECTIVES : The authors sought to evaluate whether a genetic predisposition to elevations in plasma lipids is associated with the presence of MAC.
OBJECTIVES : The causes of death in dementia are not established , particularly in rarer dementias.
OBJECTIVES : The current article explores age differences in skill acquisition.
OBJECTIVES : The current research explores how family caregivers ( @number@ ) make sense of caregiving and ( @number@ ) cope with their circumstance.
OBJECTIVES : The current study was conducted to determine if moderate alcohol doses differentially affect the driving performance of older and younger adults.
OBJECTIVES : The effect of these structural changes on the mechanical properties of the SC has not been determined.
OBJECTIVES : The effects of age-related hearing loss are severe.
OBJECTIVES : The favourable processes and mediating factors of a psychosocial group rehabilitation intervention in alleviating older people's loneliness were evaluated.
Objectives The few studies of shift work and late life cognitive functioning have yielded mixed findings.
OBJECTIVES : The global spinal sagittal alignment varies widely among healthy individuals as it is affected by not only race , but also aging.
OBJECTIVES : The goal of this research was to investigate the effectiveness of a 10-week , strength-based exercise program delivered by Extension professionals.
OBJECTIVES : The Gold Standard treatment for a non-metastatic , invasive bladder cancer is an open radical cystoprostatectomy ( ORCP ) .
OBJECTIVES : The high predictive validity of self-rated health ( SRH ) is a major strength of this widely used population health measure.
OBJECTIVES : The impact of adiposity on mortality in older adults remains controversial.
OBJECTIVES : The implementation of new health services is a complex process.
OBJECTIVES : The incidence of heart failure increases with aging.
OBJECTIVES : The increasing number of older adults with dementia is a large and growing public health problem.
OBJECTIVES : The inflammatory marker C-reactive protein ( CRP ) is associated with depression.
OBJECTIVES : The interactions between nutritional supplementation and physical activity on changes in physical function among older adults remain unclear.
OBJECTIVES : The majority of persons with dementia live in the community where most of their care is provided by family members.
OBJECTIVES : The National Social Life , Health , and Aging Project is a nationally representative , longitudinal survey of older adults.
OBJECTIVES : The number of people who will require institutional care for dementia is rapidly rising.
OBJECTIVES : The obesity epidemic in Mexico is increasing and represents a considerable public health challenge.
OBJECTIVES : The objective of the study was to investigate the treatment status of elderly patients with RA.
OBJECTIVES : The objective of this paper is to assess associations between SSO events and rates of gastrointestinal ( GI ) illness in Massachusetts.
OBJECTIVES : The objective of this study was to evaluate the benefits of influenza vaccination against hospitalization and mortality on frail elderly people.
OBJECTIVES : The objective of this study was to examine the temporal relationship between changes in major reproductive hormone levels and cognitive decline over time.
OBJECTIVES : The objectives of the study were to determine the prevalence and predictors of anticholinergic drugs use in elderly dementia patients.
OBJECTIVES : The pathways linking spousal health to marital quality in later life have been little examined at the population level.
OBJECTIVES : The population-level incidence of vocal fold paralysis after thyroidectomy for well-differentiated thyroid carcinoma ( WDTC ) is not known.
OBJECTIVES : The population of older patients with schizophrenia is increasing.
OBJECTIVES : The present study examined the association between anorexia of aging and physical frailty among older people.
OBJECTIVES : The present study examined the relation between past year frequency of binge drinking and psychological distress among older adult drinkers.
OBJECTIVES : The present study investigates age differences in the vulnerability to illusory correlations between fear-relevant stimuli and threatening information.
OBJECTIVES : The present study investigates the impact of unawareness of deficit ( anosognosia ) in patients with Alzheimer's disease upon professional health care burden.
OBJECTIVES : The primary objective was to identify factors associated with low- and high-level anticholinergic burden in nursing home residents.
OBJECTIVES : The proportion of people living with HIV / AIDS in the ageing population ( > 50 years old ) is increasing.
OBJECTIVES : The purpose of the present study was to investigate the influence of obesity on cardiac aging.
OBJECTIVES : The purpose of the study was to evaluate dietary habits and food preferences of patients in different age groups.
OBJECTIVES : The purpose of this cross-sectional study was to examine the relationship between sensory impairment and suicide ideation among elderly Koreans.
OBJECTIVES : The purpose of this paper is to present expert's positions on the main aspects of the frailty syndrome in the older persons.
OBJECTIVES : The purpose of this study is to examine the relationship between religiously based beliefs about suffering and health among older Mexicans.
OBJECTIVES : The purpose of this study was to determine the impact of age on regional aortic pulse wave velocity ( aPWV ) .
OBJECTIVES : The purpose of this study was to establish reference ranges for 2-dimensional sonographic measurements of fetal lungs from longitudinal data.
OBJECTIVES : The purpose of this study was to evaluate the effects of creative dance on physical fitness and life satisfaction in older women.
OBJECTIVES : The purpose of this study was to examine factors associated with the bereavement service utilization of bereaved dementia caregivers.
OBJECTIVES : The purpose of this study was to examine the association between social connections and happiness among members of the elder population of Taiwan.
OBJECTIVES : The purpose of this study was to explore the network types of HCBS clients based on the structural characteristics of their social networks.
OBJECTIVES : The purpose of this study was to identify the biomarkers of healthy aging and to establish BAS for healthy people in China.
OBJECTIVES : The purpose of this study was to investigate the effect of age on the capacity to acclimatise to exercise-heat stress.
OBJECTIVES : There are few methods to discern driving risks in patients with early dementia and mild cognitive impairment ( MCI ) .
OBJECTIVES : There are few studies investigating the characteristics of older smokers.
OBJECTIVES : There are many stereotypes about ageing and later life.
OBJECTIVES : There are no evidenced-based rehabilitative guidelines for postsurgical non-small cell lung cancer ( NSCLC ) patients.
OBJECTIVES : There has been a parallel increase in the incidence of obesity and diabetes as well as the number of daily meals.
OBJECTIVES : There is a growing consensus worldwide that palliative care needs to be both more inclusive of conditions other than cancer and to improve.
OBJECTIVES : There is an age associated change in GFR but this association may be influenced by the method used.
OBJECTIVES : There is a widespread consensus that diabetes impairs cognitive functioning.
OBJECTIVES : There is growing evidence for cognitive dysfunction in chronic hemodialysis patients as the age and the prevalence of comorbidities increase in this population.
OBJECTIVES : There is lack of data on the frequency and the causes of hospitalization in mild to moderate Alzheimer's disease ( AD ) patients.
OBJECTIVES : There is limited research in cognition and its relationship to mortality after hip fracture among men compared to women.
OBJECTIVES : The relationship between obesity and grip strength , a key indicator of sarcopenia , has been inconsistently reported.
OBJECTIVES : The relationship of body mass index ( BMI ) with functional status differs in diversified geriatric population and various settings.
OBJECTIVES : The search for anticataract drugs has been continuing for decades ; some treatments no longer exist but antioxidants are still of much interest.
OBJECTIVES : The study develops strategies for implementing ubiquitous healthcare ( u-health ) based on previous experiences of the healthcare professionals.
OBJECTIVES : The study examined major diatheses and stressors directly related to suicidal ideation among elderly Korean immigrants.
OBJECTIVES : The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described.
OBJECTIVES : The topic of how primary informal caregivers cope with their caregiving demands has generated significant research.
OBJECTIVES : This article investigates whether the help with care needs that is received from others depends on the potential supply of family helpers.
OBJECTIVES : This cross-sectional study examined whether spirituality moderates the association between depression symptom severity and meaning in life among treatment-seeking adults.
OBJECTIVES : This in vitro study should assess the fracture resistance of veneered zirconia-based crowns with either luted or fused veneer.
OBJECTIVES : This is an early feasibility clinical test of mitral loop cerclage annuloplasty to treat secondary mitral valve regurgitation.
OBJECTIVES : This longitudinal study investigates how activity restriction , perceived stress , and social support affect the relationship between functional disability and depressive symptoms.
OBJECTIVES : This prospective study evaluated the association of obesity and hypertension with left atrial ( LA ) volume over @number@ years.
OBJECTIVES : This review describes interventions that have been tested to improve balance confidence in older community-dwelling persons.
OBJECTIVES : This study aimed to determine relative safety and efficacy of NOACs in patients with VHD.
OBJECTIVES : This study aimed to identify participant characteristics associated with volunteering among older adults.
OBJECTIVES : This study aimed to investigate new biomarkers of obesity particularly in relation with inflammation-associated proteins using protein differential display techniques.
OBJECTIVES : This study aims to specify the processing operations underlying age-related differences in the speed and accuracy of visual search in a mathematical model.
OBJECTIVES : This study assesses nonintentional injury deaths of older farmers and the causal agents associated with these fatalities in Australia ( 2001-2015 ) .
OBJECTIVES : This study concerns culturally Deaf people in the United Kingdom who use British Sign Language ( BSL ) .
OBJECTIVES : This study evaluates the efficacy of an integrated health management program ( IHMP ) based on successful aging in older women.
OBJECTIVES : This study evaluates the Paulson-Lichtenberg Frailty Index ( PLFI ) , a self-report measure that is based on Fried's well-established frailty phenotype.
OBJECTIVES : This study examined both cross-sectional and longitudinal relationships between felt age and cognitive-affective symptom dimensions of depression in late life.
OBJECTIVES : This study examined social support and identified demographic and health correlates among American Indians aged @number@ years and older.
OBJECTIVES : This study examined subjective age and its cross-domain correlates in Chinese oldest-old.
OBJECTIVES : This study examined the effects of retirement on self-rated health for married couples , using interdependence and social stratification theoretical frameworks.
OBJECTIVES : This study examined the impact of context information on emotion recognition from a life-span developmental perspective.
OBJECTIVES : This study examined the independent and interactive effects of chronic medical conditions and sleep disturbance on depressive symptomatology.
OBJECTIVES : This study examined whether stereotypes may predict health outcomes independently from their internalization into the self.
OBJECTIVES : This study examines the impact of social ties on the relationship between widowhood and depressive symptoms among the older Korean population.
OBJECTIVES : This study examines the relationship between transitions in volunteering activity and physical and psychological health outcomes among older adults in Taiwan.
OBJECTIVES : This study examines whether physical frailty predicts a higher incidence of depression , as well as a less favorable course of depression.
OBJECTIVES : This study investigated changes in left atrial ( LA ) volumes and phasic atrial function , by deciles , with normal aging.
OBJECTIVES : This study investigated muscle strength and circulating CD34-positive cells as a marker of vascular angiogenesis.
OBJECTIVES : This study investigated the association between orthostatic hypotension ( OH ) , supine hypertension ( SH ) , and cognitive performance.
OBJECTIVES : This Study investigated the cosmetic filling efficacy of Fillerina® in decreasing the skin aging signs and in improving facial volume deficiencies.
OBJECTIVES : This study investigated the effect of riboflavin on aging in Drosophila melanogaster ( fruit fly ) .
OBJECTIVES : This study investigated the effect of smoking on hTERT expression in the skin of smokers and non-smokers.
OBJECTIVES : This study investigated toothbrush abrasion and in vitro aging on ceramic ( indirect technique ) and composite veneers ( direct technique ) .
OBJECTIVES : This study sought to assess the diagnostic and prognostic values of metabolomics in HF.
OBJECTIVES : This study sought to assess the types and patterns of atrial arrhythmias , associated factors , and age-related trends.
OBJECTIVES : This study sought to demonstrate that NS preserves characteristics associated with \ "stemness \ " in CPCs and antagonizes myocardial senescence and aging.
OBJECTIVES : This study sought to determine whether the therapeutic effect of culture-expanded MSCs persists , even in older subjects.
OBJECTIVES : This study sought to identify nonredundant atrial fibrillation ( AF ) genetic susceptibility signals and examine their cumulative relations with AF risk.
OBJECTIVES : This study sought to investigate the associations between childhood / adolescence cardiovascular risk factors and midlife cognitive performance.
OBJECTIVES : This study sought to investigate the role of secretory phospholipase A2 ( sPLA2 ) -IIA in cardiovascular disease.
OBJECTIVES : This study sought to link cardiac phenotypes in T2DM patients with clinical profiles and outcomes using cluster analysis.
OBJECTIVES : This study used a qualitative approach to explore the perspectives of adults with hearing impairment on hearing help-seeking and rehabilitation.
OBJECTIVES : This study was designed to investigate women's experiences of engaging in an age-appearance anti-smoking intervention.
OBJECTIVES : This study was designed to search putative biomarkers for detection of relatively young-onset atrial fibrillation ( AF ) .
OBJECTIVES : This systematic review examined empirical evidence of the effects of relaxation interventions on anxiety and depression among older adults.
OBJECTIVES : Thyroid autoimmunity decreases in the very old.
OBJECTIVES : To analyze the effect of adenosine on detrusor smooth muscle contraction and to assess age-related changes of adenosine function.
OBJECTIVES : To analyze the MHR in a stratified sample of active and functionally independent individuals.
Objectives : To analyze the nonsurgical treatment habits of patients prior to undergoing rhytidectomy at < 50 years of age.
OBJECTIVES : To ascertain whether a safe-transportation program can change driving exposure while maintaining community participation of older drivers.
OBJECTIVES : To assess factors predisposing to severe chemotherapy-related toxicity and adverse events ( AEs ) and dose modification in aging cancer patients.
OBJECTIVES : To assess how adverse reactions were treated and how they processed over time.
OBJECTIVES : To assess racial / ethnic disparities in pediatric utilization of community health centers ( CHCs ) among a nationally representative sample.
OBJECTIVES : To assess the association between self-reported noncancer pain and 5-year mortality.
OBJECTIVES : To assess the costs of the health effects of cigarette smoking and secondhand smoke ( SHS ) exposure to society.
OBJECTIVES : To assess the distribution of dementia subtypes in Brazil using a population-based clinicopathological study.
OBJECTIVES : To assess the effectiveness of NAC drops to prevent or reverse the progression of cataract.
OBJECTIVES : To assess the effect of mild forced physical training on cerebral blood volume ( CBV ) and other brain parameters in old mice.
OBJECTIVES : To assess the effects of SPT on behavioural and psychological symptoms and quality of life in people with dementia.
OBJECTIVES : To assess the longitudinal relationship between visual acuity ( VA ) and depressive symptoms ( DSs ) among older adults.
Objectives : To assess the long-term outcomes of the various recommended SBP levels and to determine if racial differences exist based on long-term cognitive trajectories.
OBJECTIVES : To assess the modification of the form of medication and evaluate staff observance of good clinical practices.
OBJECTIVES : To assess the nutrition risk status of community living older people and to identify associated risk factors.
Objectives : : to assess the predictors for the functional incapacity of the elderly in primary health care.
OBJECTIVES : To assess the prevalence of hypertension ( HTN ) in a random sample of individuals in Jeddah , Kingdom of Saudi Arabia.
OBJECTIVES : To assess the relationship between hormone replacement therapy ( HRT ) and coronary artery calcium ( CAC ) .
OBJECTIVES : To assess the relationship between rate of change in muscle strength and all-cause mortality.
OBJECTIVES : To assess the relationship between sensorimotor nerve function and incident mobility disability over @number@ years.
OBJECTIVES : To assess the reliability and validity of the Chinese version of Aging Perceptions Questionnaire ( C-APQ ) .
OBJECTIVES : To assess the role of advanced age on survival and dialysis dependency after initiation of renal replacement therapy for acute kidney injury.
OBJECTIVES : To assess the subjective experience of scalp , facial and body hair change in a large cohort of normal postmenopausal females.
OBJECTIVES : To categorize the health problems of older Russians and identify the number of frail older adults using different approaches.
OBJECTIVES : To compare attitudes toward dementia screening of older adults with and without an experience of dementia caregiving.
OBJECTIVES : To compare chart- and interview-based methods for identification of delirium.
OBJECTIVES : To compare energy expenditure and volume of oxygen consumption and carbon dioxide production during a high-speed yoga and a standard-speed yoga program.
OBJECTIVES : To compare hearing loss screening results of four simple tests with those of hand-held audiometry.
OBJECTIVES : To compare muscle power between youth who acquired HIV perinatally and HIV unexposed uninfected ( HUU ) youth.
OBJECTIVES : To compare muscle strength and physical performance among subjects with and without sarcopenia of different definitions.
OBJECTIVES : To compare rates of medication errors committed by assisted living staff with different training and to examine characteristics of errors.
OBJECTIVES : To compare the 3-D hip torques during a golf swing between young and senior healthy male amateur golfers.
OBJECTIVES : To compare the clinical profile of HF patients in a Romanian general hospital over a 3-year period.
OBJECTIVES : To compare the contributions of depressive symptoms and cardiovascular disease ( CVD ) severity to functional decline in individuals with coronary heart disease.
OBJECTIVES : To compare the effectiveness of injection augmentation and bilateral thyroplasty surgery in managing age-related changes of the larynx.
OBJECTIVES : To compare the validity of both measures , the ASCOT and the ICECAP-O.
OBJECTIVES : To define vitamin D levels and their association with cognition in subjects with exceptional longevity.
OBJECTIVES : To delineate the difference in nutritional risk between older adults with normal cognitive function and mild cognitive impairment living in elderly homes.
OBJECTIVES : To describe differences in morbidity and functional status according to living area.
OBJECTIVES : To describe factors that support and inhibit recruitment and participation of people with dementia living in care homes.
OBJECTIVES : To describe incidence and lethality time trends rates of pancreatic cancer ( PC ) in Brazil.
OBJECTIVES : To describe quality of care for feeding problems in advanced dementia and probability and predictors of weight loss and mortality.
OBJECTIVES : To describe quantitative and semiquantitative sonographic joint measurements in healthy adults and compare them with demographic parameters.
OBJECTIVES : To describe self-reported consequences of pain in the three spinal regions in relation to age and gender.
OBJECTIVES : To describe the distribution and implications of prostate-specific antigen velocity ( PSAV ) by prostate-specific antigen ( PSA ) in an unselected population.
OBJECTIVES : To describe the incidence of dementia in a representative sample of elderly Yoruba Nigerians and provide information about the risk factors.
OBJECTIVES : To describe the interindividual variability in physical function responses to supervised resistance and aerobic exercise training interventions in older adults.
OBJECTIVES : To describe the relationship of body mass index and mortality in older adults , examining the influence of sex and cardiovascular morbidity.
OBJECTIVES : To describe the sonoanatomy of paediatric lower-limb entheses according to age and gender.
OBJECTIVES : To describe transitions in care of persons with dementia with attention to nursing facility transitions.
OBJECTIVES : To detect the prevalence of vitamin D insufficiency among the elderly in Dakahlia.
OBJECTIVES : To determine how often outpatient physician visits detect sleep apnea ( SA ) in older persons in the United States.
OBJECTIVES : To determine how the Thai elderly perceived the benefits of herbal medicine consumption and to study related variables influencing their perception.
OBJECTIVES : To determine if there is an association between CVD and nutrition risk in advanced age.
OBJECTIVES : To determine issues of concern regarding aging and retirement among a cohort of emergency physicians in pre-retirement years.
OBJECTIVES : To determine predictors of repeat health service use in older veterans treated and released from the emergency department ( ED ) .
OBJECTIVES : To determine testosterone fractions in Japanese men and to compare these values with those of Framingham Heart Study participants.
OBJECTIVES : To determine the cross-sectional association between cerebral amyloid-beta ( Aβ ) deposition and gait.
OBJECTIVES : To determine the diagnostic accuracy of the Mini-Cog for diagnosing Alzheimer's disease dementia and related dementias in a primary care setting.
OBJECTIVES : To determine the difference in receipt of activity of daily living ( ADL ) assistance between obese and normal-weight older adults.
OBJECTIVES : To determine the durability of anabolic effects and adverse events ( AEs ) after stopping testosterone and growth hormone supplementation in older men.
OBJECTIVES : To determine the effect and cost-effectiveness of training nonnursing staff to provide feeding assistance for nutritionally at-risk nursing home ( NH ) residents.
OBJECTIVES : To determine the effectiveness of vitamin D supplementation in preventing decline in physical function in older men.
OBJECTIVES : To determine the effect of chronic disorders and their co-occurrence on survival and functioning in community-dwelling older adults.
OBJECTIVES : To determine the effect of statins on cognitive decline in healthy elderly adults.
OBJECTIVES : To determine the effects of cognitive training on cognitive abilities and everyday function over @number@ years.
OBJECTIVES : To determine the effects of increasing plant-based foods or dairy products on protein intake in older Americans by performing diet modeling.
OBJECTIVES : To determine the extent to which genetic and environmental factors contribute to individual and gender differences in aging of functional ability.
OBJECTIVES : To determine the incidence of fracture among aging HIV-infected ( HIV + ) and uninfected men ( HIV- ) .
OBJECTIVES : To determine the incidence of pulmonary diseases in HIV-infected persons compared with HIV-uninfected persons.
OBJECTIVES : To determine the incremental cost-effectiveness of sacubitril / valsartan compared with enalapril in the Netherlands using the clinical data from the PARADIGM-HF trial.
OBJECTIVES : To determine the initial efficacy of a mailed screening and brief intervention to reduce at-risk drinking in persons aged @number@ and older.
OBJECTIVES : To determine the longitudinal development of drug use in very old adults.
OBJECTIVES : To determine the nutritional status of elderly African people and to investigate the association between undernutrition and dementia.
OBJECTIVES : To determine the percentage of readmissions from post-acute care that are considered potentially avoidable from hospital and SNF perspectives.
OBJECTIVES : To determine the prevalence of , and factors associated with , potentially inappropriate anticholinergic medication use in the older population.
OBJECTIVES : To determine the prevalence of antipsychotic use in care homes.
OBJECTIVES : To determine the prevalence of dementia and cognitive impairment in older people across generations.
OBJECTIVES : To determine the relationship between advancing age and the prevalence and patterns of comorbidity among older persons with heart failure.
OBJECTIVES : To determine the relationship between neighborhood-level socioeconomic characteristics , life-space mobility , and incident falls in community-dwelling older adults.
OBJECTIVES : To determine the relative mortality associated with past and current depression , taking into account the effect of frailty.
OBJECTIVES : To determine the role of impaired functional status as a risk factor for severe Clostridium difficile infection ( CDI ) in older adults.
OBJECTIVES : To determine the safety and efficacy of an infrared device to treat upper arm laxity in aged skin.
OBJECTIVES : To determine the usefulness of physical phenotype of frailty , cognitive impairment , and serum albumin for risk stratification of elderly medical impatients.
OBJECTIVES : To determine whether alcohol use changes over time in older adults and whether alcohol intake is associated with common chronic diseases.
OBJECTIVES : To determine whether elderly people with different patterns of magnetic resonance imaging ( MRI ) findings have different long-term outcomes.
OBJECTIVES : To determine whether gene variants would affect risk for AD differently in women of different population ancestries.
OBJECTIVES : To determine whether hearing impairment , highly prevalent in older adults , is associated with activity levels.
OBJECTIVES : To determine whether hearing loss is associated with incident physician-diagnosed dementia in a representative sample.
OBJECTIVES : To determine whether improvements in aerobic capacity ( VO DESIGN : Randomized , double-blind , double-sham , controlled trial.
OBJECTIVES : To determine whether infectious burden ( IB ) is associated with worse performance and decline on a battery of neuropsychological tests.
OBJECTIVES : To determine whether objectively measured physical activity levels are associated with physical function and mobility in older men.
OBJECTIVES : To determine whether observed hearing loss ( OHL ) is associated with incident dementia in a multiethnic population.
OBJECTIVES : To determine whether performance speeds mediate the association between visual impairment and self-reported mobility disability over an 8-year period.
OBJECTIVES : To determine whether preservation of physical function with aging may be partially met through modification in dietary protein intake.
OBJECTIVES : To determine whether statin use alters response of 25-hydroxyvitamin D ( 25 ( OH ) D ) level to vitamin D treatment.
OBJECTIVES : To develop a photographic sun damage assessment scale for forearm skin and test its feasibility and utility for consistent classification of sun damage.
OBJECTIVES : To develop , implement , and evaluate a training program in aging-related health for police officers.
OBJECTIVES : To directly compare frailty incidence of older Mexican American ( MA ) and European American ( EA ) adults.
OBJECTIVES : To estimate outcomes according to attained blood pressure ( BP ) in the oldest adults treated for hypertension in routine family practice.
OBJECTIVES : To estimate resource utilization and costs of patients treated with the VKAs acenocoumarol and phenprocoumon , for the indication DVT.
OBJECTIVES : To estimate the association among knee pain and central obesity.
OBJECTIVES : To estimate the likelihood of , and factors associated with , recovery from exhaustion in older adults.
OBJECTIVES : To estimate the prevalence and demographic distribution of treated epilepsy in a community-based population.
OBJECTIVES : To estimate the prevalence and identify the predictors of depression among community-dwelling Korean American elderly ( KAE ) .
OBJECTIVES : To estimate the prevalence of 25-hydroxyvitamin D ( 25 ( OH ) D ) deficiency and its determinants among older adults in Ecuador.
OBJECTIVES : To estimate the prevalence of depression and assess association between sociodemographic parameters and depression among older adults in a rural Indian community.
OBJECTIVES : To estimate the quantity of informal care associated with neuropsychiatric symptoms in older adults with cognitive impairment.
OBJECTIVES : To evaluate a faith-based intervention ( Sisters in Motion ) intended to increase walking in older , sedentary African-American women.
OBJECTIVES : To evaluate and compare the safety and efficacy of different types of hyaluronic acid ( HA ) for nasolabial fold correction.
OBJECTIVES : To evaluate changes in the common duct diameter on sonography over time in patients with and without cholecystectomy.
OBJECTIVES : To evaluate cost-effectiveness of the Tailored Activity Program ( TAP ) for individuals with dementia and family caregivers.
OBJECTIVES : To evaluate demographics , magnetic resonance imaging ( MRI ) measures , and vascular risk among mild cognitive impairment ( MCI ) subtypes.
OBJECTIVES : To evaluate studies that have assessed the effect of dehydroepiandrosterone ( DHEA ) supplementation on body composition and physical performance in older adults.
OBJECTIVES : To evaluate the association , if any , between masticatory dysfunction ( MD ) and mortality in older adults.
OBJECTIVES : To evaluate the behavioral and functional impact of excitatory TMS in a group of healthy elders.
OBJECTIVES : To evaluate the criterion validity of two measures of fatigability , defined as performance deterioration or perceived effort to perform a standardized task.
OBJECTIVES : To evaluate the effect of angiotensin-converting enzyme inhibitors ( ACEIs ) on physical function in elderly.
OBJECTIVES : To evaluate the effect of different pathways for developing a life story book ( LSB ) for people with dementia.
OBJECTIVES : To evaluate the effect of the age on the proximal esophageal response to wet swallows.
OBJECTIVES To evaluate the efficacy of and patient satisfaction with abobotulinumtoxinA injections.
OBJECTIVES : To evaluate the impact of patient age on hospital resource use and treatment costs of acute abdominal pain ( AAP ) .
OBJECTIVES : To evaluate the incidence and characteristics of nursing home ( NH ) use after implantable ( ICD ) implantation.
OBJECTIVES : To evaluate the locally-adapted CDSMP for older adults with chronic diseases in Hong Kong in the primary care setting.
OBJECTIVES : To evaluate the relationship between gait speed , recall memory , and mortality.
OBJECTIVES : To evaluate the relationship of cognitive function with glucose tolerance status and obesity in Chinese middle-aged or aged adults.
OBJECTIVES : To evaluate vital status after five years of follow-up in a cohort of nonagenarians with functional and / or cognitive impairment at baseline.
OBJECTIVES : To evaluate whether race influences agreement between screening results and documentation of cognitive impairment and delirium.
OBJECTIVES : To examine 6-month change in life-space mobility as a predictor of subsequent 6-month mortality in community-dwelling older adults.
OBJECTIVES : To examine agreement between older persons and their surrogates regarding participation in advance care planning ( ACP ) .
OBJECTIVES : To examine alternative models of defining and characterizing successful aging.
OBJECTIVES : To examine antecedent-consequent relations of perceived control to health and social support across adulthood and old age.
OBJECTIVES : To examine associations between objective measures of activity level and mortality risk in older men.
OBJECTIVES : To examine associations between weight change , body composition , risk of mobility disability , and mortality in older adults.
OBJECTIVES : To examine associations of dietary variety with changes in lean mass and physical performance during a 4-year period in an elderly Japanese population.
OBJECTIVES : To examine associations of maternal age at childbirth and parity with survival to age @number@ years ( longevity ) .
OBJECTIVES : To examine body mass index ( BMI ) trajectories with change in lean mass and physical function in old age.
OBJECTIVES : To examine caregiver factors associated with unmet needs for care of older adults.
OBJECTIVES : To examine dose / response relationships between habitual physical activity and bone health in the elderly.
OBJECTIVES : To examine drinking trajectories followed by two cohorts of older women over @number@ to @number@ years of follow-up.
OBJECTIVES : To examine gender and age differences in levels , types and locations of physical activity.
OBJECTIVES : To examine how disparities in adult disability by educational attainment vary across US states.
Objectives : To examine how information and communication technology ( ICT ) access and use are conceptually incorporated in the Successful Aging @number@ framework.
OBJECTIVES : to examine perceived age discrimination in a large representative sample of older adults in England.
OBJECTIVES : To examine predictors of mortality in aging Mexican Americans ( MAs ) and European Americans ( EAs ) .
OBJECTIVES : To examine racial differences in the use of rehabilitation services and functional improvement during receipt of services.
OBJECTIVES : to examine the association between 34-year trajectories of social activity , from middle age to old age and late-life disability.
OBJECTIVES : To examine the association between hospitalization and annual changes in body composition and strength in older adults.
OBJECTIVES : To examine the association between life-space mobility and cognitive decline over a five-year period among older Mexican Americans.
OBJECTIVES : To examine the association between life-space mobility and different dimensions of depressive symptoms among older community-dwelling people.
OBJECTIVES : To examine the association between multiple measures of visual impairment ( VI ) and incident mobility limitations in older adults.
OBJECTIVES : To examine the association between neighborhood cohesion and risk of self-neglect in a community-dwelling Chinese-American older population.
OBJECTIVES : To examine the association between neighborhood residence and frailty prevalence in older Mexican Americans ( MAs ) .
OBJECTIVES : To examine the association between neuropsychiatric symptoms and risk of institutionalization and death.
OBJECTIVES : To examine the association between physical activity ( PA ) and Alzheimer disease ( AD ) course.
OBJECTIVES : To examine the association between plasma concentrations of antioxidative micronutrients and leukocyte telomere length ( LTL ) in elderly adults.
OBJECTIVES : To examine the association between self-reported memory failures and incident dementia in individuals aged @number@ and older.
OBJECTIVES : To examine the association between sleep complaints , use of sleep-promoting medications , and persistent severe fatigue ( PSF ) .
OBJECTIVES : To examine the association between snoring and incident cardiovascular disease ( CVD ) .
OBJECTIVES : To examine the association between statin use and objectively assessed decline in gait speed in community-dwelling older adults.
OBJECTIVES : To examine the association between usual sleep duration and mortality according to physical and mental health status in older adults.
OBJECTIVES : To examine the association between vascular pathology and rate of cognitive decline in older adults independent of Alzheimer's disease ( AD ) pathology.
OBJECTIVES : To examine the association of employment status and characteristics with prevalent and incident memory complaints ( MC ) in 55-64-year-olds.
OBJECTIVES : To examine the association of life events and social support in the broadly defined category of depression in late life.
OBJECTIVES : To examine the associations between absolute and relative handgrip strength ( HGS ) and physical performance.
OBJECTIVES : To examine the circadian pattern of cardiac autonomic modulation ( CAM ) and its attributes in general population.
OBJECTIVES : To examine the combined effect of healthy behaviors on the development of functional disability in an elderly cohort.
OBJECTIVES : To examine the effect of hospital readmission on functional recovery after elective surgery in older adults.
OBJECTIVES : To examine the impact of @number@ weeks detraining on circulating BDNF.
OBJECTIVES : To examine the individual association between BMI and level of serum uric acid ( SUA ) among the very elderly Chinese population.
OBJECTIVES : To examine the interrelationships among low serum albumin , nutritional depletion , and ongoing inflammation in older patients recovering from illness.
OBJECTIVES : To examine the longitudinal association between decline in cognitive function and risk of elder self-neglect in a community-dwelling population.
OBJECTIVES : To examine the long-term effect of sentinel injury ( unintentional injury involving serious health-related consequences ) among older adults on Medicare expenditures.
OBJECTIVES : To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia ( SCZ-TR ) .
OBJECTIVES : To examine the physical , mental , and cognitive function of centenarians.
OBJECTIVES : To examine the relationship between depression and onset of cardiovascular disease ( CVD ) among the US middle-aged and older adults.
OBJECTIVES : To examine the relationship between falls history , especially those with frequent recent falls , and future injurious falls.
OBJECTIVES : To examine the relationship between frequent falls in older drivers and motor vehicle collision ( MVC ) involvement.
OBJECTIVES : To examine the relationship between fruit and vegetable intake , physical activity , and all-cause mortality in older women.
OBJECTIVES : To examine the relationship between gait speed and falls risk.
OBJECTIVES : To examine the relationship between key functional impairments , co-morbid conditions and driving performance in a sample of cognitively normal older adults.
OBJECTIVES : To examine the relationships between loneliness , social and health behaviors , health , and mortality among older adults in China.
OBJECTIVES : To examine the relationships between psychosocial resources and deficits , elder mistreatment , and psychological well-being.
OBJECTIVES : To examine the validity of selected oxidative stress and inflammatory biomarkers for predicting incident falls in community-dwelling older adults.
OBJECTIVES : To examine whether improved diabetes control is related to better cognitive outcomes.
OBJECTIVES : To examine whether number of remaining teeth and regular dental care affect incident functional disability in elderly Japanese adults.
OBJECTIVES : To examine whether patients with newly diagnosed cancer respond differently to supplemental coverage than the general Medicare population.
OBJECTIVES : To explore associations between nutritional status , falls and selected falls risk factors amongst older hospitalized people.
OBJECTIVES : To explore older women's views about prescription osteoporosis medication use in depth and to identify specific beliefs and experiences that influence these views.
OBJECTIVES : To explore the association of 25 ( OH ) D concentrations with the frailty phenotype and its criteria.
OBJECTIVES : To explore the associations between frailty and reproductive axis hormones ( as an important regulatory system ) in middle aged and older men.
OBJECTIVES : To explore the practice patterns of general practitioners ( GPs ) for the diagnosis , disclosure and pharmacological management of individuals with dementia.
OBJECTIVES : To explore the prevalence of and factors associated with initiation of selling sex as a minor.
OBJECTIVES : To explore the relationship of general health decline assessed by frailty and risk of dementia and Alzheimer's disease ( AD ) .
OBJECTIVES : To explore the use of dietary supplements in older people attending Australian memory clinics.
OBJECTIVES : To identify abnormalities in high energy phosphate cerebral metabolism in euthymic bipolar disorder.
OBJECTIVES : To identify age differences in physical activity ( PA ) participation for women.
OBJECTIVES : To identify and evaluate the age-related nail changes and disorders in Egyptian elderly people both clinically and histopathologically.
OBJECTIVES : To identify clinical correlates of person-centered fall risk awareness and their validity for predicting falls.
OBJECTIVES : To identify , critically appraise and synthesize qualitative evidence of self-care experiences in health promotion for home-dwelling elders.
OBJECTIVES : To identify factors associated with nutrition risk among a purposive sample of those in advanced aged.
OBJECTIVES : To identify factors associated with survival to the age of @number@ years old in 70 + elderly people.
OBJECTIVES : To identify general practitioners ' ( GPs ) knowledge , practices , and obstacles with regard to the diagnosis and management of dementia.
OBJECTIVES : To identify lifestyle factors that associate with perceived facial age in white north European men and women.
OBJECTIVES : To identify predictors of extraordinary survival.
OBJECTIVES : To identify serum ferritin levels and their association with nutritional status determined by Body Mass Index in older adults at four eldercare facilities.
OBJECTIVES : to identify the effects and effectiveness of drug cessation on falls , delirium and cognitive impairment.
OBJECTIVES : To identify the relationship between diet-related indicators and overweight and obesity in older adults in rural Japan.
OBJECTIVES : To implement multicenter programs to enhance HCW influenza vaccination.
OBJECTIVES : To introduce the framework for P & E communication strategies within a younger population and explore the barriers that may be encountered.
OBJECTIVES : To investigate age differences in working memory processing , specifically the accuracy of retrieval of items stored outside the immediate focus of attention.
OBJECTIVES : To investigate associations between dementia-attitudes and help-seeking intentions.
OBJECTIVES : To investigate differences and similarities in predictors of having paid work in workers aged 55 + with and without chronic disease.
OBJECTIVES : To investigate dual-task performance of gait and cognition in cognitively healthy and cognitively impaired older adults using a motor-cognition dual-task paradigm.
OBJECTIVES : To investigate frailty as a predictor of surgical outcome in elderly patients undergoing penile prosthesis implantation.
OBJECTIVES : To investigate frailty state transitions in a cohort of older Italian adults to identify factors exacerbating or improving frailty conditions.
OBJECTIVES : To investigate patients ' views about their lowest tolerable blood glucose level and explore symptoms they may develop below that level.
OBJECTIVES : To investigate the age-related alterations in functional visual acuity ( FVA ) in healthy individuals.
OBJECTIVES : To investigate the association between rheumatoid arthritis ( RA ) and self-reported sleep duration.
OBJECTIVES : To investigate the association of dietary patterns with a 3-year incidence of depression among healthy older adults.
OBJECTIVES : To investigate the association of mood and anxiety symptoms with sleep architecture ( the distribution of sleep stages ) in community-dwelling older men.
OBJECTIVES : To investigate the effect of age-based testing ( ABT ) for driver's license renewal policies on older Australians.
OBJECTIVES : To investigate the effects of a Mediterranean type diet on patients with osteoarthritis ( OA ) .
OBJECTIVES : To investigate the effects of garlic on endothelial function in patients with ischemic stroke ( ISS ) .
OBJECTIVES : To investigate the effects of testosterone supplementation on bone , body composition , muscle , physical function , and safety in older men.
OBJECTIVES : To investigate the expression of MT in ageing skin.
Objectives : To investigate the heritability of and factors associated with GCC thickness in a healthy aging population.
OBJECTIVES : to investigate the population impact on functional disability of chronic conditions individually and in combination.
OBJECTIVES : To investigate the psychometric properties of the Executive Interview ( EXIT ) and Quick EXIT in community dwelling older adults.
OBJECTIVES : To investigate the psychometric properties of the Geriatric Suicide Ideation Scale ( GSIS ) among community-residing older adults.
OBJECTIVES : To investigate the relationship between glycated albumin ( GA ) to glycated hemoglobin ( HbA1c ) ratio and cognitive impairment in old age.
OBJECTIVES : To investigate the relationships between previous diet , biomarkers of selected B vitamins , nutritional status and length of stay.
OBJECTIVES : To investigate tobacco and alcohol consumption as risk indicators for missing teeth in late middle-aged Danes.
OBJECTIVES : To investigate whether biological markers of health differ among older adults with visual impairment compared to those with normal vision.
OBJECTIVES : To investigate whether gene nutrient interactions influence the risk of cognitive dysfunction among older persons.
OBJECTIVES : To investigate whether genetic variations on the estrogen metabolic pathway would be associated with risk of Alzheimer's disease ( AD ) .
OBJECTIVES : To investigate whether higher serum β DESIGN : Cross-sectional and longitudinal analyses of a prospective cohort.
OBJECTIVES : To investigate whether markers of obstructive sleep apnea severity are associated with gray matter changes among middle-aged and older individuals.
OBJECTIVES : To investigate whether there are racial differences in gait velocity in elderly adults.
OBJECTIVES : To longitudinally examine gender and racial disparities in driving cessation among older adults.
OBJECTIVES : To measure the safety and efficacy of intranasally delivered RA glulisine in ApoE4 carriers with mild-moderate AD.
OBJECTIVES : To objectively and quantitatively evaluate the degree of perceived age change and improvement in attractiveness following aesthetic facial surgical procedures.
OBJECTIVES : To observe the natural time course of noncognitive symptoms before the onset of symptomatic Alzheimer disease dementia.
OBJECTIVES : To present statewide representative findings on the prevalence of physical inactivity among older community residents , its correlates and associated health service use.
OBJECTIVES : To present the theoretical framework , available measurements and models for promoting work ability.
OBJECTIVES : To prioritize research topics relevant to the care of the growing population of older adults with multiple chronic conditions ( MCCs ) .
OBJECTIVES : To profile older adults receiving assistance with physician visits and prescribed medications and the time demands associated with their care.
OBJECTIVES : To provide consensus recommendations on common aesthetic problems which are treated by neurotoxin in Asians.
OBJECTIVES : To provide estimates of change in depressive symptoms and determine how changes in depressive symptom influence recovery of functional status.
OBJECTIVES : To provide physicians with an overview for treatment of dermal filler complications.
OBJECTIVES : To provide pooled data on the prevalence of malnutrition in elderly people as evaluated using the Mini Nutritional Assessment ( MNA ) .
OBJECTIVES : To provide treatment recommendations for primary prevention and early intervention in individuals with no or minimal signs of aging.
OBJECTIVES : To quantify the relative physical and cognitive demands required to complete typical functional activities in older adults.
Objectives : To rejuvenate the aging hand , we developed a targeted fat grafting technique based on the physiologic fat distribution of the hand.
OBJECTIVES : To relate 5-year lean tissue loss to habitual physical activity of elderly adults.
OBJECTIVES : To report a contemporary review from a single-institution series on Paget's disease of the temporal bone ( PDTB ) .
OBJECTIVES : To review the various hemoglobin ( Hb ) A1c methods , with a focus on interferences resulting from Hb variants.
OBJECTIVES : To robustly examine the prevalence of the double peaked P1 visual evoked potential in healthy younger and older adult populations.
OBJECTIVES : To study clinical features and etiology of hyponatremia in elderly hospitalized patients.
OBJECTIVES : To study the importance of weight change with regard to mortality in older people.
OBJECTIVES : To study tooth loss patterns in older adults with dementia.
OBJECTIVES : To summarise the evidence about the efficacy of a Mediterranean diet on the management of type @number@ diabetes and prediabetic states.
OBJECTIVES : To systematically review clinical outcomes associated with medication regimen complexity in older people.
OBJECTIVES : To test a conceptual model of secondary health conditions , age , and function in persons aging with long-term physical disabilities.
OBJECTIVES : To test the effectiveness of progressive resistance training , protein nutritional supplements and both interventions combined in the treatment of sarcopenia.
OBJECTIVES : To test whether socio-economic status and disease burden influence blood pressure in older adults.
OBJECTIVES : To understand characteristics of older at-risk drinkers and reasons why they decide to change or maintain their alcohol consumption.
OBJECTIVES : To understand how caring for grandchildren affects the physical and mental health of grandparents in Taiwan.
OBJECTIVES : To understand the effects of different retinoid formulations on the expression of genes associated with biological processes that undergo changes during skin aging.
OBJECTIVES : To understand the perceptions of seniors with heart failure ( HF ) regarding smart-home systems to monitor their physiological parameters.
OBJECTIVES : To understand what steps best prepare patients and surrogates for decision making.
OBJECTIVES : To update histological data on crown initiation and completion ages in southern Africans.
OBJECTIVES : To use the Coronary Artery Risk Development in Young Adults ( CARDIA ) study to explore the development of heart-lung interactions.
OBJECTIVES : to validate the MSRA questionnaire proposed as prescreening tool for sarcopenia , in a population of community-dwelling elderly subjects.
OBJECTIVES : to verify whether declining levels of circulating thyroid hormones may contribute to longevity.
OBJECTIVES : Toxicodynetics aims at defining the time-course of major clinical events in drug overdose.
OBJECTIVES : ( TPN ) can act as a bridge to enteral nutrition.
OBJECTIVES : Transitions from marriage to widowhood are consequential and fraught with risk in developing country contexts.
OBJECTIVES : Traumatic Brain Injury ( TBI ) is a common and debilitating injury that is particularly prevalent in patients over @number@
OBJECTIVES : Traumatized parents may transmit anxieties of physical deterioration and demise to their offspring.
OBJECTIVE : Studies examining depressive symptoms and negative mood across the postmenopause are lacking , particularly those that examine prevalence in early and late postmenopause.
OBJECTIVE : Studies have shown a correlation between cancer and cognition referred to as \ "chemo brain. \ "
OBJECTIVE : Studies indicate a limited understanding of dementia and its associated symptoms , causes and consequences among South Asian older adults.
OBJECTIVE : Studies in rodents and humans have indicated that omega-3 polyunsaturated fatty acids ( n-3 PUFA ) may reduce weight.
OBJECTIVE : Studies in type @number@ diabetes report both increased mortality for normal weight and no evidence of an obesity paradox.
OBJECTIVE : Subclinical thyroid disorders are common in older individuals.
OBJECTIVE : Subjective cognitive complaints are often used in the diagnosis of memory and other cognitive impairment.
OBJECTIVE : Subjective cognitive complaints in otherwise normal aging are common but may be associated with preclinical Alzheimer disease in some individuals.
OBJECTIVE : Subjective well-being ( SWB ) is an important predictor of mortality.
OBJECTIVE : Subjective well-being was evaluated three weeks after Super Typhoon Haiyan struck the Philippines.
OBJECTIVE : Substance abuse among older adults is a looming public health concern.
OBJECTIVES : Understanding and managing the process of aging is a central issue in modern society.
Objective Supraventricular arrhythmias are commonly detected in patients with anti-mitochondrial antibody M2 ( AMA-M2 ) -associated myopathy.
OBJECTIVE : Survivors of critical illness are frequently left with long-lasting disability.
OBJECTIVES : Using CT to describe normal aortic-arch morphology and its changes with age and sex.
OBJECTIVES : Using protein transduction domains ( PTD ) , we investigated whether PTD-EGF and FGF1 transduced into skin cells and tissue.
OBJECTIVES : Vascular deterioration is suggested to occur earlier in black than white populations , thereby increasing their risk for developing hypertension.
OBJECTIVES : Virtual touch tissue quantification is a promising new implementation of the acoustic radiation force impulse ultrasound technique.
OBJECTIVES : Visual media influence the general public's perceptions and attitudes regarding people with mental conditions.
OBJECTIVES : Vitamin D deficiency has been reported to be associated with the risk of cardiovascular disease.
OBJECTIVES : Vitamin K plays a pivotal role in the synthesis of Matrix Gla protein ( MGP ) , a calcification inhibitor in vascular tissue.
OBJECTIVES : Vitamins and herbal extracts are associated with various side effects , potential serious drug interactions and mostly unproven efficacy.
OBJECTIVES : We aimed to assess dose-response relationships of current and lifetime active smoking exposure with F2RL3 methylation.
OBJECTIVES : We aimed to evaluate the association between circulating androgens and the presence of psychological symptoms in a sample of healthy middle-aged women.
OBJECTIVES : We aimed to examine the mortality associated with elder abuse across levels of psychological and social factors.
OBJECTIVES : We aim to elucidate the role of health behaviors and health conditions in the association between depression and mortality.
OBJECTIVES : We assessed the utilization of home care by the elderly in Brazil after implementation of the Family Health Strategy ( FHS ) .
OBJECTIVES : We compared the nutritional status of elderly people living in two different settings ( shared-housing arrangements and home-living arrangements ) .
OBJECTIVES : We compared these anesthetic techniques on the postoperative quality of recovery early in elderly patients.
OBJECTIVES : We determined the incidence and clinical outcome of CIN in the Japanese elderly patient.
OBJECTIVES : We determined whether community-level income inequality was associated with mortality among a cohort of older adults in São Paulo , Brazil.
Objectives : We document the size and characteristics of the population of older adults without close kin in the contemporary United States.
OBJECTIVES : We estimated associations between job insecurity and change over time in the physical and psychological health of older adult men and women.
OBJECTIVES : We evaluated anthropometric parameters and physical fitness in elderly Japanese.
OBJECTIVES : We evaluated the effect of long-term exposure to black carbon on levels and rates of decline in lung function in the elderly.
OBJECTIVES : We evaluated the effect of Restylane Vital® with its specialized injector on volume correction and skin tone of nasojugal groove.
OBJECTIVES : We evaluated the relationships between sex steroid levels and heart rate variability ( HRV ) parameters.
OBJECTIVES : We examined if individually-adapted nutritional counselling could prevent > @percent@ weight loss among elderly patients @number@ months after discharge from a rehabilitation institution.
OBJECTIVES : We examined neighborhood-level foreclosure rates and their association with onset of depressive symptoms in older adults.
OBJECTIVES : We examined regional variation in tooth loss in the United States from @number@ to @number@
OBJECTIVES : We examined the associations between birth weight and intelligence at @number@ different adult ages.
OBJECTIVES : We examined the associations between depressive symptoms and sexual identity and behavior among women with or at risk for HIV.
OBJECTIVES : We examined the effect of triolein treatment of UVB-irradiated keratinocytes on MMP1 ( interstitial collagenase ) expression response of dermal fibroblasts.
OBJECTIVES : We examined the efficiency of country-specific health care spending in improving life expectancies for men and women.
OBJECTIVES : We examined the relationship between childhood and adult socioeconomic position ( SEP ) and objectively assessed , later-life functioning.
OBJECTIVES : We examined the roles of utilitarian and recreational walking in relation to occurrence of outdoor falls in older adults.
OBJECTIVES : We examined whether older adults use plausibility-checking strategies while verifying arithmetic problems.
Objectives : We explore the culturally specific meaning of successful aging in Singapore , an ethnically diverse city-state in Asia.
OBJECTIVES : We explore whether spousal caregiving is associated with enhanced well-being for older husbands and wives.
OBJECTIVES : We have previously described the antifibrotic role of the soluble guanylate cyclase ( sGC ) .
OBJECTIVES : We hypothesized greater frailty would be associated with subsequent mortality , disability , and cognitive impairment , regardless of age.
OBJECTIVES : We hypothesized that the LFA is a key morphologic parameter in the diagnosis of LCSS.
OBJECTIVES : Weight change in older adults affects physical function ( PF ) .
OBJECTIVES : We investigated associations between positive marital quality and health among married persons aged @number@ or older and their spouses.
OBJECTIVES : We investigated cross-sectional and longitudinal associations between cytokine profiles and asthma outcomes.
Objectives We investigated whether the extent of biomechanical exposures and job strain in midlife separately and jointly predict disability in old age.
OBJECTIVES : We sought to describe PFAS serum concentrations ' temporal trends among Gullah African American residents of coastal South Carolina.
OBJECTIVES : We sought to determine the relationship of AD to the presence and morphological features in coronary and thoracic atherosclerosis.
OBJECTIVES : We sought to evaluate the safety and efficacy of a novel fractional unipolar RF device on facial tightening.
OBJECTIVES : We sought to examine the prospective influence of social capital and social network ties on smoking relapse among adults.
OBJECTIVES : We studied possible effects of prematurity , procedural pain and opioids in humans @number@ years later.
OBJECTIVES : Whether and how patients should be told their dementia diagnosis , has been an area of much debate.
OBJECTIVES : Whether there are racial and ethnic disparities in the rate of cognitive decline among older adults is not clear.
OBJECTIVES : Whilst a range of psychosocial interventions are used for people with dementia , there lacks evidence for the processes which underpin them.
OBJECTIVES : White matter ( WM ) integrity within the mesial temporal lobe ( MTL ) is important for episodic memory ( EM ) functioning.
OBJECTIVES : Why are older people perceived as more competent in some countries relative to others ?
OBJECTIVE : Systemic low graded inflammation has been identified as a possible biological pathway in late-life depression.
OBJECTIVE : T2 relaxation times on MRI are sensitive to the configuration of cartilage collagen and continually increase during aging in adults.
OBJECTIVE : Telomere length is a marker of biological aging that has been linked to cardiovascular disease risk.
OBJECTIVE : Telomeres and associated proteins are regulators of cellular survival , regeneration and aging.
OBJECTIVE : Telomeres are regions at the ends of chromosomes that maintain chromosomal structural integrity and genomic stability.
OBJECTIVE : Telomere shortening , a biomarker of cellular aging , has been associated with aging-related diseases.
OBJECTIVE : Telomeres which are formed by double-strand breaks and DNA under replication , cause cell cycle arrest resulting in cellular senescence and apoptosis.
OBJECTIVE : Temporal lobe resection is an established treatment for medication-resistant temporal lobe epilepsy , which in recent years has increasingly been performed in children.
OBJECTIVE : Testosterone plays a vital role in brain function and behavior.
OBJECTIVE : The 2f2-f1 DPOAE is not as popular as the 2f1-f2 DPOAE in the clinical realm as it is not as robust.
OBJECTIVE : The ability to perceive facial emotion varies with age.
OBJECTIVE : The advantages of empowering direct care workers ( DCWs ) within nursing homes ( NHs ) are well documented.
OBJECTIVE : The age-dependent performance of electrocardiographic ( ECG ) criteria was examined for left ventricular hypertrophy ( LVH ) prediction.
OBJECTIVE : The ageing process is accompanied by a variety of cellular modifications , and telomere shortening is a common finding.
OBJECTIVE : The aim of current study was to explore the effect of intergenerational and intragenerational support on perceived health of older adults.
OBJECTIVE : The aim of our study is to validate the efficacy and safety of autologous plasma filler in treating nasolabial fold wrinkles.
OBJECTIVE : The aim of our study was to investigate whether @number@ wk of oral magnesium supplementation can improve physical performance in healthy elderly women.
OBJECTIVE : The aim of the current study was to examine the effect of negative life events and widowhood on the incidence of dementia.
OBJECTIVE : The aim of the paper was to determine whether there was a sufficient number of articles on the elderly in domestic medical journals.
OBJECTIVE : The aim of the study was to validate the Calorie Intake Tool ( CIT ) , a new tool to estimate energy intake.
OBJECTIVE : The aim of this in vivo study was to investigate the influence of age on optical properties of pure enamel and enamel-dentine complex.
OBJECTIVE : The aim of this longitudinal study was to examine the effects of ageing on glucose regulation in elderly Chinese men and women.
OBJECTIVE : The aim of this paper is to describe the different compensatory mechanisms for patients with severe degenerative lumbar spine.
OBJECTIVE : The aim of this pilot study was to compare the efficacy of ALA-PDT and red light alone in the treatment of photoaging.
OBJECTIVE : The aim of this retrospective data analysis was to investigate the influence of the method of RNMB reversal on postoperative outcome.
OBJECTIVE : The aim of this study is to explore the spectral patterns of spontaneous magnetoencephalography ( MEG ) activity across the lifespan.
OBJECTIVE : The aim of this study is to investigate the presenting profile of patients with carpal tunnel syndrome ( CTS ) at various ages.
OBJECTIVE : The aim of this study was to analyze the effects of dance therapy on selected hematological and rheological indicators in older women.
OBJECTIVE : The aim of this study was to assess participants ' characteristics related to delivery mode and use of intervention materials.
OBJECTIVE : The aim of this study was to assess the association between frailty and risk for heart failure ( HF ) in older adults.
OBJECTIVE : : The aim of this study was to better understand the linkages between impairment and activity limitation among groups of elderly community-living persons.
OBJECTIVE : The aim of this study was to clarify the associations between LOH , low T , and sexual symptoms with mortality in men.
OBJECTIVE : The aim of this study was to compare the effects of CA and RF on human skin.
OBJECTIVE : The aim of this study was to compare the frequency and type of DRPs identified by several prescribing criteria.
OBJECTIVE : The aim of this study was to compare the functional and cognitive changes exhibited by the elderly over a 6-month period.
OBJECTIVE : The aim of this study was to describe physiological load and psychological stress of Finnish firefighters during a 24-hour work shift.
OBJECTIVE : The aim of this study was to determine the risk of cancer among elderly IBD patients compared with younger IBD patients.
OBJECTIVE : The aim of this study was to estimate prevalence and patterns of lifetime alcohol misuse.
Objective : The aim of this study was to estimate the associations between UI and back problems in the Canadian men and women.
OBJECTIVE : The aim of this study was to evaluate the association between loneliness in elderly people with the use of psychotropic drugs.
OBJECTIVE : The aim of this study was to evaluate the effect of abciximab in elderly high-risk ACS patients undergoing PCI.
OBJECTIVE : The aim of this study was to evaluate the effects of application of microdermabrasion in human skin rejuvenation.
OBJECTIVE : The aim of this study was to evaluate the efficiency of molar distalization depending on age and second-molar eruption using the Beneslider.
OBJECTIVE : The aim of this study was to examine differences in survival time associated with a healthy lifestyle versus a less healthy lifestyle.
OBJECTIVE : The aim of this study was to examine lane change strategies in active younger and older drivers.
OBJECTIVE : The aim of this study was to examine the association between MetS and longitudinal changes in cognitive function.
OBJECTIVE : The aim of this study was to examine the association of sedentary behaviour patterns with frailty in older people.
OBJECTIVE : The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring.
OBJECTIVE : The aim of this study was to examine the relationship between vitamin D status and functional limitations.
OBJECTIVE : The aim of this study was to examine the risk of mortality associated with anticholinergic use among elderly nursing home residents with depression.
OBJECTIVE : The aim of this study was to examine the role of myeloid cell mitoOS in atherosclerosis in aged mice.
OBJECTIVE : The aim of this study was to identify and quantify therapeutic conflicts in emergency department patients with multimorbidity.
OBJECTIVE : The aim of this study was to identify novel genes that regulate body fat mass.
OBJECTIVE : The aim of this study was to identify the key issues that affect the adoption of ICT in the aged care sector.
OBJECTIVE : The aim of this study was to identify the prevalence and assessment strategies of Biological Fragility Syndrome in the Elderly.
OBJECTIVE : The aim of this study was to illuminate the meaning of vulnerability to older persons themselves.
OBJECTIVE : The aim of this study was to investigate the level and predictors of work disability in different age groups.
OBJECTIVE : The aim of this study was to investigate the link between the left-handedness and neurotic disturbances in an adult urban population.
OBJECTIVE : The aim of this study was to investigate the rate of complications and recovery related to a hip fracture in patients with PD.
OBJECTIVE : The aim of this study was to map out the developmental curve of the orbital volume of Chinese children aged 1-15 years.
OBJECTIVE : The aim of this systematic review was to determine if oral iron therapy is effective in elderly people with iron deficiency anaemia.
OBJECTIVE : The aim of this systematic review was to evaluate the burden of non-adherence to cardiovascular medications and factors thereof in Australia.
OBJECTIVE : The aim of this work was to evaluate the time course of changes in strength and functional performance in elderly hospitalized medical patients.
OBJECTIVE : The aim was of this study is to assess the prevalence of osteoporosis in a population of women diagnosed with sarcopenia.
OBJECTIVE : The aim was to assess pharyngeal airway dimensions and physiological changes based on lateral cephalometric radiographs from healthy untreated children aged 6-17 years.
OBJECTIVE : The aim was to evaluate the association between AC-drug use and HRQoL in community-dwelling older adults.
OBJECTIVE : The aim was to evaluate the effect of flavanol consumption on cognitive performance in cognitively intact elderly subjects.
OBJECTIVE : The aim was to investigate the influence of environmental exposures on hearing loss in a twin cohort.
OBJECTIVE : The APOA2 gene has been associated with obesity and insulin resistance ( IR ) in animal and human studies with controversial results.
OBJECTIVE : The association between exposure to stressful life events ( SLEs ) and late-life depression is well-documented.
OBJECTIVE : The authors describe a technique for improving the obtuse cervicomental angle.
OBJECTIVE : The authors evaluate real-world changes in facial aesthetic treatment patterns and patient satisfaction following the introduction of incobotulinumtoxinA in Argentina.
OBJECTIVE : The authors evaluate the results of periorbital filling with hyaluronic acid ( HA ) in a small series of patients.
OBJECTIVE : The authors implemented a VR training intervention to try to lessen cognitive decline and improve memory functions.
OBJECTIVE : The authors present a radiofrequency ( RF ) technique to treat crow's feet that can prevent complications while simultaneously maintaining long-term results.
OBJECTIVE : The authors sought to identify risk factors for repeat self-harm and completed suicide over the following year among adults with deliberate self-harm.
OBJECTIVE : The characteristics of familial colorectal cancer type X are poorly defined.
OBJECTIVE : The Chinese population has been aging rapidly and the country's economy has experienced exponential growth during the past three decades.
OBJECTIVE : The current paper investigates the influence of electrode drift on distribution of electric fields generated by conventional tDCS.
OBJECTIVE : The current review aims to evaluate the sensory stimulation interventions in terms of reducing sleeping disturbances in patients with dementia.
OBJECTIVE : The current study examines whether triterpenoids and polysaccharide-enriched G. lucidum ( GL ) influence antioxidation and hepatoprotective efficacy by suppressing oxidative stress.
OBJECTIVE : The debate is a basic issue in the field of the neuropathological basis of schizophrenia ( SCH ) .
OBJECTIVE : The determinants of insulin-associated weight gain in type @number@ diabetes mellitus ( T2DM ) are partly unknown.
OBJECTIVE : The development of the perception of changes in facial emotion was investigated using event-related potentials ( ERPs ) in children and adults.
OBJECTIVE : The diagnosis of mild cognitive impairment ( MCI ) and dementia requires detailed neuropsychological examinations.
OBJECTIVE : The effect of different exercise programs on cervical flexor muscles dimensions in patients with chronic neck pain is yet to be demonstrated.
OBJECTIVE : The effect of local immunotherapy with bacille Calmette-Guérin in elderly patients with non-muscle-invasive bladder cancer has not yet been fully evaluated.
OBJECTIVE : The effects of age and gender on the magnitude of myocyte regeneration and the origin of newly formed cardiomyocytes were determined.
OBJECTIVE : The elderly population is steadily increasing in the modern world.
OBJECTIVE : The elderly with multiple chronic conditions face the complex task of medication management.
OBJECTIVE : The extent to which individuals with ET who have clinically significant cognitive impairment are aware of their cognitive changes is unclear.
OBJECTIVE : The extracts of Nitraria genus are composed of Nitraria alkaloids and have been used traditionally as a hypoglycemic medicine.
OBJECTIVE : The goal of our study was to assess whether a Web-based intervention increases physical activity and improves metabolic health in inactive older adults.
Objective : The goal of this review was to summarize available data on all relevant costs associated with HI among adults.
OBJECTIVE : The goal of this study was to investigate the role of endogenous amyloid-β peptide ( Aβ ) in healthy brain.
OBJECTIVE : The goal was to develop equations to estimate energy requirements of ALS patients.
OBJECTIVE : The goal was to investigate TSH dynamics in @number@ healthy adults.
OBJECTIVE : The Holocaust has become an iconic example of immense human-made catastrophes , and survivors are now coping with normal aging processes.
OBJECTIVE : The human amniotic epithelial cells ( hAECs ) are a recently identified new type of stem cells.
OBJECTIVE : The human body changes as it becomes older.
OBJECTIVE : The impact of postmenopausal vaginal atrophy and women's coping strategies were evaluated through international focus groups.
OBJECTIVE : The implementation of bereavement interventions is frequently requested , and its effectiveness has been controversial.
OBJECTIVE : The incidence of preterm birth is increasing worldwide.
OBJECTIVE : The interaction between dementia and nutritional state is very complex and not yet fully understood.
OBJECTIVE The introduction of ventriculoperitoneal shunts changed the way hydrocephalus was treated.
OBJECTIVE : The longitudinal trajectories that individuals may take from a state of normal cognition to HIV-associated dementia are unknown.
OBJECTIVE : The main purpose of this study was to examine factors influencing PTs to organize PA in LTCF for older adults.
OBJECTIVE : The maintenance of youthful skin appearance is strongly desired by a large proportion of the world's population.
OBJECTIVE : The Mini-Mental State Examination ( MMSE ) is used to estimate current cognitive status and as a screen for possible dementia.
OBJECTIVE : The minor G-allele of FOXO3A rs2802292 has been associated with longevity.
OBJECTIVE : The morphology of articular cartilage ( AC ) enables painless movement.
OBJECTIVE : The notion that artistic capability increases with dementia is both novel and largely unsupported by available literature.
OBJECTIVE : The number of elderly patients diagnosed with hepatocellular carcinoma ( HCC ) is expected to increase.
OBJECTIVE : The number of older adults with alcohol use disorder ( AUD ) is expected to significantly increase in the coming years.
OBJECTIVE : The objective of our study was to investigate the pathogenesis of sensitive skin.
OBJECTIVE : The objective of the study was to examine associations between AGEs and cognitive functions.
OBJECTIVE : The objective of this article was to explore trends in licensing among babyboomer older drivers in the state of Victoria , Australia.
OBJECTIVE : The objective of this paper was to evaluate a chronic care management program piloted by a visiting nurses association.
OBJECTIVE : The objective of this research was to devise a simple , rapid method for the measurement of unmetabolized plasma FA in epidemiologic studies.
OBJECTIVE : The objective of this review is to identify , through the best available evidence , how women experience UI worldwide.
OBJECTIVE : The objective of this study is to evaluate the appropriateness of current available PILs for use by older adults.
OBJECTIVE : The objective of this study is to explore the sensitivity to intermodal asynchrony in audiovisual speech with moderate to severe sensorineural hearing loss.
OBJECTIVE : The objective of this study was to analyze the efficacy of multisensory versus muscle strengthening to improve postural control in healthy community-dwelling elderly.
OBJECTIVE : The objective of this study was to ascertain provider perspectives on key drivers of live discharge from the Medicare hospice program.
OBJECTIVE : The objective of this study was to assess variables associated with xerostomia in patients on chronic hemodialysis ( HD ) .
OBJECTIVE : The objective of this study was to determine the knowledge and perception of hormone replacement therapy among women in Enugu South-East Nigeria.
OBJECTIVE : The objective of this study was to determine the risk factors for future pressure ulceration in a community sample.
OBJECTIVE : The objective of this study was to develop a quantitative MRI disease progression measurement for clinical trials.
OBJECTIVE : The objective of this study was to evaluate cross-sectional and longitudinal associations between ankle-brachial index ( ABI ) and indicators of cognitive function.
OBJECTIVE : The objective of this study was to evaluate the efficacy of NSAIDs in the treatment of AD using a meta-analysis approach.
OBJECTIVE : The objective of this study was to evaluate the psychometric properties of the impact on participation and autonomy ( IPA ) questionnaire.
OBJECTIVE : The objective of this study was to examine metabolic and behavioral adaptations to long-term CR longitudinally in rhesus macaques.
OBJECTIVE : The objective of this study was to examine the association of plasma estradiol and testosterone with risk for dementia in elderly men.
OBJECTIVE : The objective of this study was to identify nutritional indicators that predict MNA ( mini nutritional assessment ) classification in hospitalized elderly patients.
OBJECTIVE : The objective of this systematic review was to investigate the impact of discontinuing medicines with anticholinergic properties on cognitive outcomes in older people.
OBJECTIVE : The objective was to compare bicarbonate ( HCO3 ) measured in arterialized venous blood samples to skeletal outcomes.
OBJECTIVE : The objective was to determine the association between BMI and all-cause mortality risk in adults ≥65 y of age.
OBJECTIVE : The objective was to determine the risk of stroke associated with subclinical hypothyroidism.
OBJECTIVE : The objective was to elucidate novel biologic pathways that may influence circulating TFAs by evaluating associations between common genetic variation and TFA biomarkers.
OBJECTIVE : The objective was to evaluate the association of peripheral and central hearing abilities with cognitive function in older adults.
OBJECTIVE : The objective was to examine the characteristics of Veterans with schizophrenia admitted for nonpsychiatric hospitalizations.
OBJECTIVE : The objective was to investigate how multivitamin use is associated with the long- and short-term risk of CVD.
OBJECTIVE : The objective was to review , summarize , and evaluate the key studies of procedural therapies using bipolar and multipolar RF technologies.
OBJECTIVE : The potentially different psychological effects of ongoing trauma vis-à-vis an intense time-limited exposure to trauma have not been examined in older adults.
OBJECTIVE : The precuneus is @number@ of the major cortical hubs and plays an important role in normal aging and verbal fluency processing.
OBJECTIVE : The prediction of successful aging by midlife body mass index ( BMI ) and waist circumference ( WC ) was examined.
OBJECTIVE : The present study aimed to compare the activation of trunk and lower limb muscles during walking in younger and older women.
OBJECTIVE : The present study examined the effects of caregiving stress and ageing on neutrophil function in young and older individuals.
OBJECTIVE : The present study examined the impact of BP from childhood to mid-adulthood on retinal microvascular architecture.
OBJECTIVE : The present study investigated the long-term evolution of BPSD over one year after CBU discharge.
OBJECTIVE : The present study investigates the relationship between BMI and all-cause mortality among middle-aged and older adults with or without pre-existing diseases.
OBJECTIVE : The present study was conducted to investigate the effects of chronic stroke on the recognition of basic emotions in music.
OBJECTIVE : The prevalence of chronic heart failure ( CHF ) in the elderly population is growing.
OBJECTIVE : The prevalence of diabetes in the Eastern Mediterranean Region ( EMR ) is among the highest in the world.
OBJECTIVE : The prevalence of multimorbidity has risen considerably because of the increase in longevity and the rapidly growing number of older individuals.
OBJECTIVE : The prevalence of subjective sleep and cognitive complaints increases with age.
OBJECTIVE : The purpose of the current experiment was to evaluate WM performance after training individuals to use effective encoding strategies.
OBJECTIVE : The purpose of the present study was to examine the effects of age and visual content on cross-modal enhancement of auditory speech detection.
OBJECTIVE : The purpose of the study was to review the current status of room temperature biospecimen storage.
OBJECTIVE : The purpose of this article is to describe an original surgical technique allowing to treat the hollow eye.
OBJECTIVE : The purpose of this paper is to present a proposed framework to support evidence informed policymaking in ageing and health.
OBJECTIVE : The purpose of this study is to characterize the health status of older adults with hoarding.
OBJECTIVE : The purpose of this study is to determine the relationship between occupational exposures and hearing among elderly Latino Americans.
OBJECTIVE : The purpose of this study was to characterize sleep in patients with FTD and their family caregivers.
OBJECTIVE : The purpose of this study was to compare risk stratification between ScoliScore and traditional clinical estimates to determine whether ScoliScore provides unique information.
OBJECTIVE : The purpose of this study was to determine whether age influences the relationship between alcohol consumption and metabolic syndrome.
OBJECTIVE : The purpose of this study was to evaluate the TSH-free T₄ relationship in a large sample.
OBJECTIVE : The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults.
OBJECTIVE : The purpose of this study was to identify differences in orofacial muscle strength according to age and sex in healthy East Asian adults.
OBJECTIVE : The purpose of this study was to investigate gender-specific differences in the perioral skin.
OBJECTIVE : The purpose of this study was to investigate the clinical and economic outcomes associated with COPD in Medicare beneficiaries residing in LTC facilities.
OBJECTIVE : The purpose of this study was to update evidence-based recommendations on the best practices for chiropractic care of older adults.
OBJECTIVE : The ratio of psychological to organic ED changes with aging.
OBJECTIVE : There are few reports on the prognosis of patients receiving androgen replacement therapy ( ART ) .
OBJECTIVE : There are numerous reports about the leptin concentration ( LC ) in postmenopausal women ( PW ) .
OBJECTIVE : There are several neuropathological scales for staging of Alzheimer pathology.
OBJECTIVE : The recognition of the limits between normal and pathological aging is essential to start preventive actions.
OBJECTIVE : There have been few studies examining the relationship between chronic obstructive pulmonary disease ( COPD ) and psychiatric morbidity in Hong Kong.
OBJECTIVE : There is an increasing interest for the value of right ventricle ( RV ) in predicting exercise tolerance and prognosis in cardiovascular disease.
OBJECTIVE : There is evidence to suggest that older adults are underrepresented in randomized controlled trials of health interventions.
OBJECTIVE : There is increasing evidence suggesting that low total testosterone concentration is associated with incident type @number@ diabetes mellitus ( T2DM ) in men.
OBJECTIVE : There is mounting evidence for the contribution of apoE to the pathophysiology of Alzheimer disease ( AD ) .
OBJECTIVE : There is no epidemiological study on the prevalence of impulse control disorders ( ICDs ) in the elderly population.
OBJECTIVE : The relation of overweight to dementia is controversial.
OBJECTIVE : The relationship between body composition and mortality in frail older people is unclear.
OBJECTIVE : The relationship between inflammatory markers and depressive symptoms has been reported inconsistently.
OBJECTIVE : The relationship between sleep complaints , comorbidity and health-related quality of life ( HRQoL ) in advanced age has not been clearly established.
OBJECTIVE : The relationship between stress , social support , and cognition in geriatric depression is complex.
OBJECTIVE : The relationship between weight loss and mortality has important clinical and public health significance but has proved to be complex.
OBJECTIVE : The role of insulin-like growth factor-1 ( IGF-1 ) in bone health in men is debatable.
OBJECTIVE : The role of lymphadenectomy in endometrial cancer is still uncertain.
OBJECTIVE : The role of sedentary behaviour in metabolically healthy obesity is unknown.
OBJECTIVE : The role of social relationships in determining well-being may be particularly salient in ageing populations.
OBJECTIVE : The Self-Management of Well-being ( SMW ) group intervention for older women was implemented in health and social care.
OBJECTIVE : The SLCO1B1 c.521T > C polymorphism is associated with statin plasma levels and simvastatin-induced adverse drug reactions.
OBJECTIVE : The study aimed to characterize cancer-related concerns among women with a new diagnosis of gynecological cancer from a developmental life stage perspective.
OBJECTIVE : The study aims to explore the patterns and changes of active and passive smoking in the elderly population.
OBJECTIVE : The study aim was to determine natural variability in somatosensation across age groups using brief measures.
OBJECTIVE : The study examined the relationships between social contact types and psychological distress among mid-older adults.
OBJECTIVE : The study was primarily designed to determine whether energy provided by snacks and diet quality were associated with coping behaviors to manage stress.
OBJECTIVE : The study was undertaken to compare the skin care related activities of retinol and bakuchiol , a potential alternative to retinoids.
OBJECTIVE : The use of drugs with intrinsic anticholinergic properties is widespread among old age persons.
OBJECTIVE : The use of physicians is more common than of behavioral specialists , especially in underserved Asian American communities.
OBJECTIVE : The use of tube feeding for elderly patients with poor nutritional intake is a ubiquitous method of feeding.
OBJECTIVE : The vaginal microbiota helps protect the female genital tract from disease.
OBJECTIVE : The value of metabolic syndrome ( MetS ) in childhood and adolescence and its stability into young adulthood have been questioned.
OBJECTIVE : The world population is aging rapidly and the well-being of older people is of great interest.
OBJECTIVE : The world's largest aging population resides in China.
OBJECTIVE : The worldwide population aging and the nowadays medical advances impose to consider new management guidelines for elderly.
OBJECTIVE : Thioredoxin-1 ( Trx-1 ) , one important antioxidative enzyme in endothelial cells , is required for apoptosis inhibition.
OBJECTIVE : This 30-day pilot study was designed to compare the effectiveness and safety of standard needles with that of blunt cannulas for CaHA application.
OBJECTIVE : This article describes a selection of current healthcare research studies and projects in Germany.
OBJECTIVE : This article describes the aspects of modern therapy that can improve survival , reduce hospitalisation and improve quality of life for CHF patients.
OBJECTIVE : This article discusses the role of the GP in the diagnosis and management of people with dementia.
OBJECTIVE : This article examines the predictors of body satisfaction among older men and women.
OBJECTIVE : This article investigated how a multicomponent memory intervention affected memory for prose.
OBJECTIVE : This article presents a method for evaluating drivers influencing the change in age distributions among prisoners.
OBJECTIVE : This article presents a research that deals with the study of collective residences for the elderly.
OBJECTIVE : This commentary discusses the common challenges of research on pharmacotherapy in older adults and provides strategies to overcome such challenges.
OBJECTIVE : This commentary offers a discussion of the need to consider behavioral interventions such as physical exercise as integral components of personalized medicine.
OBJECTIVE : This cross-sectional study aimed to explore the association between late-life spiritual activity participation and cognitive function in older Chinese adults in Hong Kong.
OBJECTIVE : This cross-sectional study tested the efficacy and feasibility of upper extremity task-specific training in older adults , including those with lower cognitive scores.
OBJECTIVE : This international multicenter study evaluated patient satisfaction and safety with long-term continuous facial aesthetic treatment with onabotulinumtoxinA.
OBJECTIVE : This is the first study to characterize systemwide tissue expression of transmembrane α-Klotho in humans.
OBJECTIVE : This paper aims to explore women's experiences of premenstrual symptoms in three Asian countries and the factors affecting the prevalence of these symptoms.
OBJECTIVE : This paper describes the trajectories of nutritional status and cognitive impairment and their correlation among older Taiwanese over @number@ year after hip-fracture surgery.
OBJECTIVE : This paper reflected on the prevalence of hypertension and diabetes in Bangladesh , which is spreading rapidly in low-income countries.
OBJECTIVE : This paper reports on a novel technology-based assessment battery of everyday competence that includes ecologically valid simulations of daily activities important to independence.
OBJECTIVE : This paper reviews the state of the science on psychological and neural contributions to appetite self-regulation in the context of obesity.
OBJECTIVE : This phase @date@ clinical study was designed to establish the safety of RT002 for the treatment of moderate-to-severe glabellar lines.
OBJECTIVE : This prospective study examined the relationships of aging , persist overweight and plasma fatty acids with arterial stiffening over @number@ years.
OBJECTIVE : This research focuses on ethnic variations in the intraindividual changes in self-rated health.
OBJECTIVE : This review addresses the question whether insulin sensitivity and mitochondrial oxidative capacity are independently affected during aging and type @number@ diabetes.
OBJECTIVE : This review aims to evaluate the current evidence in the literature on microneedling.
OBJECTIVE : This review aims to touch upon the diverse modalities used to achieve the best therapeutic approach for eyelid tightening.
OBJECTIVE : This review evaluates the research design , methods , and findings of eHealth literacy interventions for older adults.
OBJECTIVE : This single-centre cross-sectional study aimed to investigate the metabolic and gonadal risk factors of vascular diseases in elderly males.
OBJECTIVE : This study aimed at defining the incidence and demographics of clinically diagnosed retinal vein occlusion ( RVO ) in Korea.
OBJECTIVE : This study aimed to assess the efficacy and safety of @percent@ stabilized retinol on photodamaged skin during a one-year treatment.
OBJECTIVE : This study aimed to determine the sociodemographic and health factors that influence older adults who continue to participate in the workforce.
OBJECTIVE : This study aimed to evaluate and compare the measures of frailty , comorbidity , and disability in predicting 1-year mortality in geriatric inpatients.
OBJECTIVE : This study aimed to examine gender-specific associations between functional autonomy and physical capacities in independent older women and men.
OBJECTIVE : This study aimed to examine the cross-sectional and longitudinal relationships between physical frailty at baseline and depressive symptoms at baseline and at follow-up.
OBJECTIVE : This study aimed to identify risk factors for premature hair graying ( PHG ) in young men.
OBJECTIVE : This study aimed to investigate the use of BZDs in acute care settings and explore their association with falls.
Objective : This study aimed to investigate whether information on cortical and trabecular bone predict fracture risk independently of aBMD and clinical risk factors.
OBJECTIVE : This study aims to evaluate the changes in the rheological parameters of blood in older women with spondyloarthrosis , who underwent whole-body cryotherapy.
OBJECTIVE : this study aims to explore the genetic and environmental impact on normal cognitive ageing in the Chinese twins.
OBJECTIVE : This study aims to identify social , psychological , and biomedical risk factors for current and future driving cessation in older adults.
OBJECTIVE : This study aims to identify the relationship among social functioning , polypharmacy and depression among older patients in Hong Kong.
OBJECTIVE : This study aims to investigate the factors that discriminate different menopausal age groups.
OBJECTIVE : This study aims to investigate the influence of socio-demographic , health , and municipal characteristics on trends in loneliness among community-dwelling elderly people.
OBJECTIVE : This study assessed whether physical function can indicate a risk of decline in higher-level functional capacity.
OBJECTIVE : This study compared urban and rural factors associated with life satisfaction among older adults in mainland China.
OBJECTIVE : This study compares the effects of these two treatment modalities on periorbital static wrinkles and lines.
OBJECTIVE : This study considers the long-term health consequences of child maltreatment.
OBJECTIVE : This study examined age group differences in the rates of depression diagnosis and treatment using a national probability sample.
OBJECTIVE : This study examined associations of regional fat depots with all-cause mortality over @number@ years of follow-up.
OBJECTIVE : This study examined potential predictors of nurses ' intentions to work during the @number@ influenza A ( H1N1 ) pandemic.
OBJECTIVE : this study examined public attitudes to current stoppage policy , information preferences and intentions to request screening beyond the age of routine invitations.
OBJECTIVE : This study examined the association between objectively measured sedentary activity and metabolic syndrome among older adults.
OBJECTIVE : This study examined the independent and interactive effects of acculturation and social activity on depressive symptoms.
OBJECTIVE : This study examined the prevalence and correlates of suicidal ideation among U.S. Chinese older adults.
OBJECTIVE : This study examined the prospective association between unforgiveness and self-reported physical health and potential positive psychological mediators of this association.
OBJECTIVE : This study examined triage accuracy before and after the @number@ revisions.
OBJECTIVE : This study examined unmet needs for home- and community-based services ( HCBS ) among frail older Americans.
OBJECTIVE : This study examined whether telomere length measured in @number@ distinct fetally derived tissues were significantly different between black and white women.
OBJECTIVE : This study examined whether there is an association between height and BP levels in Japanese adolescents.
OBJECTIVE : This study examined work status and musculoskeletal discomfort ( MSD ) amongst older Albertans.
OBJECTIVE : This study examines and compares respondent , interviewer , and physician ratings of overall health.
OBJECTIVE : This study examines relationships between local-area age structure and health at older ages.
OBJECTIVE : This study examines temporal trends in hip fracture related utilization and outcomes among elderly fee-for-service Medicare beneficiaries.
OBJECTIVE : This study examines the association between dietary patterns and cognitive decline in Taiwanese aged @number@ years and older.
OBJECTIVE : This study examines the perception , knowledge , and help-seeking tendency toward elder mistreatment among Chinese older adults.
OBJECTIVE : This study examines the role of environmental correlates of overweight and obesity among older adults independent of walking activity and lower body function.
OBJECTIVE : This study examines whether mental and physical health relate differently to work ability and whether these associations vary with coping style.
OBJECTIVE : This study examines working memory ( WM ) in mild cognitive impairment ( MCI ) and Alzheimer's disease ( AD ) .
OBJECTIVE : This study focuses on this relativity between resting heart rate and plasma NT-proBNP levels in a surveyed community-based population.
OBJECTIVE : This study identifies additional variables that predict hearing loss after radiosurgery.
OBJECTIVE : This study identifies fall risk factors in an understudied population of older people who receive community-based care services.
OBJECTIVE : This study investigated the association between maternal age at birth of last child and likelihood of survival to advanced age.
OBJECTIVE : This study investigated the effect of verbal prompting on elders ' 10-year longitudinal change in everyday cognition.
OBJECTIVE : This study investigated the long-term cytotoxic response of thermoplastic polyamide and conventional polymethyle metacrylate ( PMMA ) denture base materials.
OBJECTIVE : This study investigated the relationship between family caregivers ' mental health and postoperative recovery for elderly patients with hip fracture in Taiwan.
OBJECTIVE : This study investigated whether polypharmacy and falls-risk medications are associated with fall-related hospital admissions from LTCFs compared with hospital admissions for other causes.
OBJECTIVE : This study investigates the association between vitamin D status and the metabolic syndrome in community-dwelling older persons in the Netherlands.
OBJECTIVE : this study investigates the ease with which patients with differing functional ability use three types of MMD.
OBJECTIVE : This study investigates the independent and combined potential of slowed gait speed and slowed processing speed as predictors of adverse health outcomes.
OBJECTIVE : This study is a systematic analysis of regional and local ( urban-rural ) rates of over-weight among elderly people in China.
OBJECTIVE : This study sought to examine associations between Sal-T and health-related factors in men and women age 18-74 years.
Objective : This study sought to examine the relationship between NAFLD and diabetes and prediabetes in a large cohort based on Chinese male elderly.
OBJECTIVE : This study sought to examine the risk factors associated with hypertension among the elderly in Ghana.
OBJECTIVE : This study sought to report patient characteristics , risk factors , and trends in management for astroblastoma patients.
OBJECTIVE : This study strives to determine whether estimated dietary AGEs estimated from national diets and epidemiological studies are associated with increased AD incidence.
OBJECTIVE : This study synthesized the results from the reviewed studies and determined whether exercise training improves SRF in adolescents with ID.
Objective : This study used Rasch analysis to examine the psychometric properties of the MAL and LF-MAL in patients with stroke.
OBJECTIVE : This study was aimed to investigate the effects and potential mechanisms of age-related cardiac modifications in an older zebrafish population.
OBJECTIVE : This study was conducted to estimate oral colonization by Streptococcus mutans and Streptococcus sanguinis in adults with high and without any caries experience.
OBJECTIVE : This study was conducted to investigate associations between eyelash characteristics and age.
OBJECTIVE : This study was done to determine whether serum sclerostin levels vary by season in healthy older men and women.
OBJECTIVE : This study was undertaken to evaluate the efficacy and safety of daptomycin in elderly patients.
OBJECTIVE : Tissue Doppler imaging ( TDI ) is used routinely to quantify left ventricular function and filling pressure.
OBJECTIVE : To analyse the barriers to the prescription of AVK therapy , with special attention on geriatric characteristics.
OBJECTIVE : To analyse the development of inflammation in adipose tissue , liver , muscle and hypothalamus during ageing and the effects of caloric restriction.
OBJECTIVE : To analyze changes in the hypertrophied ligamentum flavum and clarify their etiology.
OBJECTIVE : To analyze data on patients with unintentional therapeutic errors involving insulin managed by @number@ regional poison control centers.
OBJECTIVE : To analyze non-redundant questions on independence in activities of daily living in the elderly , representing the spectrum of dependency.
OBJECTIVE : To analyze perceptual-auditory and acoustic characteristics of children's voices of different age ranges.
OBJECTIVE : To analyze similarities among factors associated with the components of frailty in elderly.
OBJECTIVE : To analyze the association between frailty and Fear of Falling ( FoF ) in a cohort of older adults with previous falls.
OBJECTIVE : To analyze the characteristics of acute occupational poisoning accidents reported in Jiangsu Province between @number@ to @number@
OBJECTIVE : To analyze the clinical features , diagnosis and treatment of lung cancer associated paraneoplastic limbic encephalitis ( PLE ) .
OBJECTIVE : To analyze the effect of FS on treatment compliance in older hypertensive patients.
OBJECTIVE : To analyze the measles immunity level of persistent population in Beijing.
OBJECTIVE : To analyze the operating situation of a physician-staffed helicopter emergency medical service in eastern Shizuoka prefecture.
OBJECTIVE : To analyze the predisposing factors for pancreatic fistula after pancreaticoduodenectomy.
OBJECTIVE : To analyze the relationship between ST and clinical and demographic factors in a sample of patients treated with RUL-UB ECT.
OBJECTIVE : To analyze the relationship of genetic and mechanical factors with age of onset of knee osteoarthritis ( OA ) .
OBJECTIVE : To analyze the repeatability and variability in plantar pressure considering mean , peak and asymmetries during aged gait.
OBJECTIVE : To analyze vestibulo-ocular responses using the video head impulse test in the yaw axis.
OBJECTIVE : To ascertain the sympathetic innervation of the internal thoracic artery and to assess the effect of aging on this artery by histomorphometry.
OBJECTIVE : To assess age differences in the costs of language planning and production.
Objective : To assess associations between hallmark AD pathology and novel quantitative neuroimaging markers while being sensitive to white matter myelin content.
OBJECTIVE : To assess associations between nonalcoholic fatty liver disease ( NAFLD ) and measures of brain health in a population-based sample of adults.
OBJECTIVE : To assess both knowledge and attitudes among nursing students on Pressure Ulcer Prevention Evidence-Based Guidelines.
OBJECTIVE : To assess bowel function and gastrointestinal quality of life among adults with operated Hirschsprung's disease ( HD ) .
OBJECTIVE : to assess changes in technical quality of care over @number@ years , and associations with participants ' characteristics.
OBJECTIVE : To assess current uses of distance learning and opinions concerning the appropriate use of distance education in RT education programs nationwide.
OBJECTIVE : To assess heart failure prevalence , epidemiology , co-morbidities and polypharmacy in our region from electronic patient records.
OBJECTIVE : To assess insulin resistance in young nonobese patients with AGA with and without metabolic syndrome.
OBJECTIVE : To assess multiple measures of tolerability and lip function in a randomized controlled trial of SGP-HA ( without lidocaine ) for lip augmentation.
OBJECTIVE : To assess overall knowledge , attitudes , and practices related to conception and fertility among reproductive-age women in the United States.
OBJECTIVE : To assess radiation exposure time during robot-guided vertebral body augmentation compared with other published findings.
OBJECTIVE : To assess relationships between refractive error and ocular and general parameters.
OBJECTIVE : To assess the association between differences in thyroid function within the reference range and CHD risk.
OBJECTIVE : To assess the association between midlife body mass index ( BMI ) and healthy aging ( HA ) in the French SU.VI.MAX cohort.
OBJECTIVE : To assess the association of common variation in genes in fatty acid pathways with SCA risk.
OBJECTIVE : To assess the association of overweight / obesity with impairment of physical and psychological QoL and sexual functions in men.
OBJECTIVE : To assess the burden and chemical and mineralogical composition of stent coating at both stent ends , with evaluation of associated risk factors.
OBJECTIVE : To assess the burden of mortality attributable to Alzheimer disease ( AD ) dementia in the United States.
OBJECTIVE : To assess the clinical characteristics and long-term outcomes in young men with suspected PAIS in relation to the results of AR analysis.
OBJECTIVE : To assess the clinical safety and effectiveness of focused cold therapy ( FCT ) for the reduction of hyperdynamic forehead wrinkles.
OBJECTIVE : To assess the construct and convergent validity of the @number@ items of the Late-Life Disability Instrument ( LLDI ) in Latin American seniors.
OBJECTIVE : To assess the contribution of dementia-related neuropathologic lesions to age-related and disease-related change in cognitive function.
OBJECTIVE : To assess the contributions of diseases to disability burden among older persons in China.
OBJECTIVE : to assess the correlation between under-reporting of energy intake ( EI ) and different percentages of body fat in independent older people.
OBJECTIVE : To assess the effectiveness and safety of combining non-ablative fractional treatments with optimized intense pulsed light.
OBJECTIVE : To assess the effectiveness and safety of currently recommended vaccines in older adults.
OBJECTIVE : To assess the effectiveness of non-equipment based rehabilitation interventions for older adults with an age-related hearing or visual impairment.
OBJECTIVE : To assess the effectiveness of psychosocial interventions for the prevention of depression in older people.
OBJECTIVE : To assess the effect of age on pre- and post-conization HPV genotype distribution.
OBJECTIVE : To assess the effect of age on the increase in DM prevalence in Spain between @number@ and @number@
OBJECTIVE : To assess the effect of combined hypertension ( HT ) and aging on left atrial ( LA ) size and phasic function.
OBJECTIVE : To assess the effect of memantine on the activity of the DMN in moderate to severe Alzheimer's disease.
OBJECTIVE : To assess the effect of onabotulinumtoxinA on elimination of mild lines at repose.
OBJECTIVE : To assess the efficacy of incobotulinumtoxinA for treating glabellar frown lines ( GFLs ) in men.
OBJECTIVE : To assess the extent to which polypharmacy and aging are associated with potential DDIs in outpatients at a medical centre in Taiwan.
OBJECTIVE : To assess the impact of age on referral for osteoporosis screening.
OBJECTIVE : To assess the impact of disability and social determinants of health on condition-specific readmissions beyond current risk adjustment.
OBJECTIVE : To assess the impact of using MCAs in self-reported adherence and clinical biomarkers of elderly patients followed in a community pharmacy.
OBJECTIVE : To assess the implications of adopting the WHO Child Growth Standards to classify Indonesian children according to nutrition status.
OBJECTIVE : To assess the influence of sensory information on static body balance of elderly individuals with vestibular disorders.
OBJECTIVE : To assess the involvement of small nerve fibers in Charcot-Marie-Tooth type 1A ( CMT1A ) .
OBJECTIVE : To assess the kinetics and the long-term evolution of skin pigmentation and tensile functions in sunbed worshippers over a period of @number@ years.
OBJECTIVE : To assess the level of oxidative stress and its relationship with reproductive hormones at various developmental phases of women.
OBJECTIVE : To assess the MRI appearance of normal skeletal development of the glenoid and glenoid-coracoid interface in the pediatric population.
OBJECTIVE : To assess the nature of beliefs and values among older adults with a focus on changes in worldview over time.
OBJECTIVE : To assess the nutritional status of Alzheimer's disease ( AD ) patients with no other associated dementia , according to disease stage.
OBJECTIVE : To assess the potential association between growth during the first @number@ years of life and the risk of overweight in childhood.
Objective : To assess the potential effectiveness of interventions for preventing falls.
OBJECTIVE : To assess the predictive value of gait speed for early death in older outpatients with cancer.
OBJECTIVE : To assess the prevalence of anemia and associated factors in older adults.
OBJECTIVE : To assess the prevalence of cardiovascular risk factors in adult urban and rural Congolese subjects.
OBJECTIVE : To assess the prevalence of IMT and arterial calcifications in HD patients and to correlate image findings with clinical and laboratory data.
OBJECTIVE : To assess the prevalence of tinnitus along with factors potentially associated with having tinnitus.
OBJECTIVE : To assess the rate of death in MCI overall , and by subtype , in the population-based Mayo Clinic Study of Aging.
OBJECTIVE : To assess the role of functional status as a risk factor for nosocomial infections in the elderly.
OBJECTIVE : To assess whether discontinuation of antihypertensive treatment in older persons with mild cognitive deficits improves cognitive , psychological , and general daily functioning.
OBJECTIVE : To assess whether sensorimotor peripheral nerve function is associated with muscle power in community-dwelling older men.
OBJECTIVE : To assess whether the risk of incidence of Alzheimer disease ( AD ) varies over time.
OBJECTIVE : To avoid causing complication , variations in their dimensions were studied.
OBJECTIVE : To better characterize the clinical presentation and outcome of PVO in the elderly.
OBJECTIVE : To better understand the factors shaping EOL care in Nunavik to support the development of a sustainable model of care.
OBJECTIVE : To better understand the impact of genetics on resilience and successful aging , we tested a model of successful aging.
OBJECTIVE : To characterize and compare age-associated changes in brain imaging and fluid biomarkers in PSEN1 E280A mutation carriers and noncarriers.
OBJECTIVE : To characterize change through 5-year follow-up , associated with training , booster , adherence , and other characteristics.
OBJECTIVE : To characterize distribution and predictors of CFL patterns.
OBJECTIVE : To characterize from a vibrational point of view the alterations caused by aging on human oocytes.
OBJECTIVE : To characterize LONMO and LONMOSD , and to analyze their predictive factors of disability and death.
OBJECTIVE : To characterize methodological changes in sperm morphology assessment and to correlate sperm morphology with clinical outcome.
OBJECTIVE : To characterize older adults in Bogotá with high blood pressure and identify factors associated to this condition within this population.
OBJECTIVE : To characterize primary-care physicians ' decisions to prescribe antidepressants to older patients with depression.
OBJECTIVE : To characterize skin wrinkles and rigidity in recently menopausal women.
OBJECTIVE : To characterize the histological and epidemiological features of male lung cancer patients in China.
OBJECTIVE : To characterize treatment trajectories in children newly diagnosed with attention-deficit / hyperactivity disorder ( ADHD ) .
OBJECTIVE : To clarify the prevalence and clinical characteristics of myasthenia gravis ( MG ) in Japan.
OBJECTIVE : To compare Berg Balance Scale ( BBS ) rating using videos with differing transmission characteristics with direct in-person rating.
OBJECTIVE : To compare calculated and reported rates of high-risk prescribing among Medicare Advantage plans.
OBJECTIVE : To compare cerebellar PC loss in ET , with normal and tremor dominant Parkinson's disease [ PD ] control brains.
OBJECTIVE : To compare clinical , histological , and immunohistochemical effects of low-dose ISO and @percent@ topical RA to treat photoaging.
OBJECTIVE : To compare differences in self-rated oral health among community-dwelling Black , Hispanic , and White adults aged @number@ and older.
OBJECTIVE : To compare incobotulinumtoxinA with onabotulinumtoxinA in the treatment of crow's feet.
OBJECTIVE : To compare markers of semen quality and related reproductive indicators in middle-aged males in relation to serum prostate-specific antigen ( PSA ) levels.
OBJECTIVE : To compare @number@ self-management interventions for improving BP control among hypertensive patients.
OBJECTIVE : To compare prevalence of common health conditions and predictors of mortality in oldest old Mexican Americans and non-Hispanic whites.
OBJECTIVE : To compare rejuvenation efficiency of intense pulsed light ( IPL ) with nonablative @number@ , 064-nm Q-switched laser in Asian patients.
OBJECTIVE : to compare sex differences in LE in phenotypic frailty categories and disability at age ≥50 between European countries.
OBJECTIVE : To compare the characteristics of trauma in the elderly under and over 80-years-old.
OBJECTIVE : To compare the clinical effectiveness and side effects of fractional bipolar RF with those of fractional erbium-doped glass in atrophic acne scars treatment.
OBJECTIVE : To compare the detectability of the different auditory evoked responses in patients with retrocochlear lesion.
OBJECTIVE : To compare the dose-response relationship of two doses of onabotulinumtoxinA in hyperdynamic POLs.
OBJECTIVE : To compare the efficacy of incobotulinumtoxinA and other BoNTAs for aesthetic applications.
OBJECTIVE : To compare the mortality-predictive ability of the full- and short-form ( SF ) Mini Nutritional Assessment ( MNA ) .
OBJECTIVE : To compare the numbers of mast cells showing tryptase and chymase in the healthy-looking skin of smokers and non-smokers.
OBJECTIVE : To compare the performances of fecal occult blood quantitive testing instrument and colloidal gold strip method in colorectal cancer screening.
Objective : To compare the prevalence of dementia in the United States in @number@ and @number@
OBJECTIVE : To compare the prevalence of frailty , measured with different diagnostic tools , among elderly nursing home residents.
OBJECTIVE : To compare the risk of jaw osteonecrosis after intravenous ( IV ) bisphosphonate administered to patients with cancer vs patients without cancer.
OBJECTIVE : To compare the risks for development of cataracts between statin users and nonusers.
OBJECTIVE : To compare the safety , efficacy , and duration of response of daxibotulinumtoxinA with onabotulinumtoxinA and placebo [ www.clinicaltrials.gov NCT02303002 ] .
OBJECTIVE : To compare the SMM to fat-free mass ( FFM ) ratio as well as anthropometric variables and body composition among @number@ ethnic groups.
Objective To compare the strength and size of the toe flexor muscles of older adults relative to their younger counterparts.
OBJECTIVE : to compare the usual walking speed of our participants against that required by the TMG.
OBJECTIVE : To compare the utility of stroke and haemorrhage risk-prediction instruments in the treatment of AF among frail older adults.
OBJECTIVE : To compare three commonly employed gait assessments - self-reported walking difficulties , clinical evaluation , and quantitative gait - to predict incident falls.
OBJECTIVE : To compare TL between BD patients and healthy controls , and to search for potential modeP < rators for observed differences.
OBJECTIVE : to compare young and older healthy adults in navigation within a simulated environment with and without a functional-cognitive task.
OBJECTIVE : To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach.
OBJECTIVE To contrast the rates of diabetes complications and mortality across age and diabetes duration categories.
OBJECTIVE : To correlate glial HO-1 overexpression with altered miRNA patterns , which have been linked to the aforementioned \ "core \ " neuropathological features.
OBJECTIVE : To create a concise reference material for existing and new practitioners who wish to be updated about the available technologies.
OBJECTIVE : To create and validate a frailty assessment tool for community-dwelling adults aged ≥75 years.
OBJECTIVE : To define an optimal model for the decline in circulating antimüllerian hormone ( AMH ) with age and develop a validated age-related nomogram.
OBJECTIVE : To define the neurologic characteristics and course of ataxia-telangiectasia ( A-T ) .
OBJECTIVE : To define the normal limits for Q wave measurements from the digitally recorded ECGs of healthy young athletes.
OBJECTIVE : To delineate the superior ( facial ) extent of the platysma muscle.
OBJECTIVE : To demonstrate a possible relationship between negative emotionality in mastocytosis and leukocytes telomere length.
OBJECTIVE : To demonstrate how physicians with unusual performance concerning the adenoma detection rate may be identified in screening colonoscopy databases.
OBJECTIVE : To demonstrate that ETR and TP are distinct dermatologic disorders.
OBJECTIVE : To demonstrate the role of BoNT-A treatment of the upper platysma and its impact on lower face dynamics and contour.
OBJECTIVE : To depict the trajectory of BMI from middle to late adulthood and to examine social variations in BMI trajectories.
OBJECTIVE : To derive an algorithm for genetic testing of patients with frontotemporal lobar degeneration ( FTLD ) .
OBJECTIVE : To derive the 3D-CAM , a new 3-minute diagnostic assessment for CAM-defined delirium , and validate it against a clinical reference standard.
OBJECTIVE : To describe 10-year progression rates to intermediate or advanced AMD.
OBJECTIVE : To describe a practical method for family practitioners to stage chronic obstructive pulmonary disease ( COPD ) by the use of office spirometry.
OBJECTIVE : To describe a stepwise approach to systems redesign for this patient population.
OBJECTIVE : To describe , from the staff perspective , positive / negative experiences related to caring for dying residents.
OBJECTIVE : To describe functional goals and factors associated with goal attainment among low-income older adults with disabilities living in the community.
OBJECTIVE : To describe glycemic control in nursing home residents with diabetes and to evaluate the relevance of HbA1c in the detection of hypoglycemia risk.
OBJECTIVE : to describe grip strength of older people in rehabilitation and nursing home settings.
OBJECTIVE : To describe older people's perceptions of anemia in a rural Ugandan population.
OBJECTIVE : To describe specific fundus features of a white population with the R1210C rare variant.
OBJECTIVE : To describe the acquisition of anticipatory postural adjustment ( APA ) in healthy adults during standing forward reaching.
OBJECTIVE : To describe the age-related changes of the soft tissue facial profile from the second to fourth decades of life.
OBJECTIVE : To describe the association between vascular risk factors and impaired ability to perform daily living activities , independent of established cardiovascular disease.
OBJECTIVE : To describe the associations between occupational exposures and age at natural menopause in the Jinchuan cohort.
OBJECTIVE : to describe the clinical features and diagnosis of severe asthma with fungal sensitization ( SAFS ) .
OBJECTIVE : To describe the health needs of survivors of war and conflict in the immediate and long-term resettlement periods.
OBJECTIVE : To describe the home hospice patients at HCA Hospice Care ( HHC ) Singapore from @number@ to @number@
OBJECTIVE : To describe the prevalence and correlates of pain during the last @number@ years of life.
OBJECTIVE : To describe the prevalence and sociodemographic factors associated with informal and paid care for Brazilian older adults with functional limitations.
OBJECTIVE : To describe the public health impact of osteoporosis including the magnitude of the problem and important consequences of osteoporotic fractures.
OBJECTIVE : To describe the scope of surrogate decision making , the hospital course , and outcomes for older adults.
OBJECTIVE : To describe VR services for individuals aging with MS , SCI , LEP and MD and the impact of aging on employment status.
OBJECTIVE : To design and validate a reliable wrinkle assessment scoring scale.
OBJECTIVE : To determine age-related association of Her-2 / neu expression with histological and immunohistochemical prognostic markers in female breast carcinoma.
OBJECTIVE : To determine age-specific serum anti-Müllerian hormone ( AMH ) values for women presenting to U.S. fertility clinics.
OBJECTIVE : To determine and compare gait speed during head-forward and side-to-side head-turn walking in individuals with lower versus greater lateral balance.
OBJECTIVE : To determine arterial stiffness and β-amyloid ( Aβ ) deposition in the brain of dementia-free older adults.
OBJECTIVE : To determine associations between circulating markers of immune activation , immune cell senescence , and inflammation with HIV-associated abnormalities of pulmonary function.
Objective : To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status.
OBJECTIVE : To determine differences in nutritional status of elderly people living alone compared to those who live in family surroundings.
OBJECTIVE : To determine dose-dependent effects of T administration on voice changes in women with low T levels.
OBJECTIVE : To determine how age may modulate the association of a history of cancer with a 12-month history of anxiety and depressive disorders.
Objective : To determine how chronological and biological aging influence myofibrillar protein synthesis ( MyoPS ) .
OBJECTIVE : To determine how older adult spouses react to their partners ' interpersonal suffering.
OBJECTIVE : To determine how the degree of urbanization affects the prevalence of allergic sensitization and self-reported rhinitis symptoms in elderly community populations.
OBJECTIVE : To determine if a correlation exists between the use of OTC medicines and adherence to prescribed medications in elderly patients.
OBJECTIVE : To determine if adding frailty measures to the EuroSCORE II improves model performance in predicting postoperative delirium.
Objective : To determine if a multigene classifier is associated with indolent behavior of invasive breast cancers in women followed for @number@ decades.
OBJECTIVE : To determine if antidepressant drug usage is associated with cognitive impairment or dementia , including Alzheimer disease ( AD ) .
Objective : To determine if antioxidant supplements ( vitamin E or selenium ) used alone or in combination can prevent dementia in asymptomatic older men.
OBJECTIVE : To determine if exercise is associated with the 10-year cumulative incidence of olfactory impairment.
OBJECTIVE : To determine if latent lymphedema is apparent underlying warts and in skin affected by cutaneous neoplasia.
OBJECTIVE : To determine if sarcopenia modulates the response to a physical activity intervention in functionally limited older adults.
OBJECTIVE : To determine if there are significant differences in the latencies of cervical and ocular evoked myogenic potentials between elderly and adult patients.
OBJECTIVE : To determine if there is an association between lead exposure and cognitive decline in women.
OBJECTIVE : To determine impact of age , gender , and vocal training on voice characteristics of children aged 6-13 years.
OBJECTIVE : To determine optimal combination of chemotherapy and surgery aimed at preserving survival of patients with locally advanced bladder cancer.
OBJECTIVE : To determine risk and protective factors for mild cognitive impairment ( MCI ) among persons @number@ years and older.
OBJECTIVE : To determine the association between CSF and PET amyloid biomarkers ( cross-sectional and longitudinal measures ) and compare the cutoffs for these measures.
OBJECTIVE : To determine the association between hypertension at age @number@ years , treatment , and 5-year mortality.
OBJECTIVE To determine the association between self-reported sleep variables and Aβ deposition in community-dwelling older adults.
OBJECTIVE : To determine the association of gender with the presentation , outcome , and host response in critically ill patients with sepsis.
Objective : To determine the association of wealth with mortality and disability among older adults in the United States and England.
OBJECTIVE : To determine the associations between classes of antihypertensive medication use and the risk of cognitive impairment among elderly hypertensive men.
OBJECTIVE : To determine the biological mechanism of the TriPollar RF device for localized fat and cellulite reduction as well as the collagen remodeling effect.
OBJECTIVE : To determine the characteristics of the newly injured and prevalent population with spinal cord injury ( SCI ) and assess trends over time.
OBJECTIVE : To determine the effectiveness of cardiac drugs for reducing mortality in the elderly Medicare HF population.
OBJECTIVE : To determine the effectiveness of unsupervised Nintendo Wii Fit balance training in older adults.
OBJECTIVE : To determine the effect of acculturation on becoming frail and prefrail over a 10-year period among older Mexican Americans.
OBJECTIVE : To determine the effect of BoNT A solution applied topically on the skin surface immediately after ablative fractional CO2 laser treatment.
OBJECTIVE : To determine the effect of testosterone administration on subclinical atherosclerosis progression in older men with low or low-normal testosterone levels.
OBJECTIVE : To determine the effects of a simple exercise program on the balance and strength of postmenopausal women with osteoporosis.
OBJECTIVE : To determine the effects of iron deficiency and iron-deficiency anemia on psychomotor development in childhood.
OBJECTIVE : To determine the effects of social support on mortality among the aged people with major diseases or ADL disabilities.
OBJECTIVE : To determine the effects that BoNTA injections for the treatment of facial wrinkles had on quality of life ( QOL ) and self-esteem.
OBJECTIVE : To determine the efficacy and safety of incobotulinumtoxinA for the treatment of platysmal bands.
Objective : To determine the efficacy and safety of propranolol compared with steroid as a first-line treatment for IH.
OBJECTIVE : To determine the efficacy of BLT in elderly patients with MDD.
OBJECTIVE : To determine the efficacy of one versus three injection sites of AbobotulinumtoxinA ( ABO ) in the treatment of lateral canthal rhytides.
Objective : To determine the epidemiology and clinical course of functional impairment and decline in middle age.
OBJECTIVE : To determine the extent to which geriatric patients with diabetes mellitus experience psychological insulin resistance ( PIR ) .
OBJECTIVE : To determine the factors that predict change in well-being over time in older men and women presenting to the falls prevention clinic.
OBJECTIVE : To determine the frequency and classification of adverse events ( AEs ) associated with fractionated carbon dioxide ( CO₂ ) laser treatment.
OBJECTIVE : To determine the frequency and the phenotypical spectrum of SCA15.
OBJECTIVE : To determine the impact of AIBDs on quality of life and work productivity.
OBJECTIVE : To determine the impact of an implementation intervention designed to introduce policies and practices supportive of healthy eating in centre-based child-care services.
OBJECTIVE : To determine the impact of dental prosthetic condition on food consumption , risk of malnutrition and follow-up 4-year mortality risk in elderly Taiwanese.
OBJECTIVE : To determine the impact of probiotics on the prevention of problems with bowel movements malnutrition and infection.
OBJECTIVE : To determine the impact of self-reported marijuana use on the components of successful aging of HIV-infected persons.
OBJECTIVE : To determine the incidence and characteristics of AWP in the adult CF population in Northern Ireland.
OBJECTIVE : To determine the long-term effect of RP on male SF and EF over @number@ yr of follow-up.
OBJECTIVE : To determine the molecular function of CCRK in HBV-associated HCC.
OBJECTIVE : To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia.
OBJECTIVE : To determine the physical indicators associated with oral intake status and swallowing function in gastrostomy patients under long-term care.
Objective : To determine the population-level association between persistent pain , which may reflect chronic pain , and subsequent cognitive decline.
OBJECTIVE : To determine the postural strategies used to regain balance following a voluntary lateral step and compare these strategies between young and older adults.
OBJECTIVE : To determine the predictors of conversion from mild cognitive impairment to dementia among Mexican older adults.
Objective : To determine the prevalence of CCM in a population-based sample of older adults.
OBJECTIVE : To determine the prevalence of radiographical Scheuermann disease in a Dutch population and evaluate the consistency of diagnostic criteria.
OBJECTIVE : To determine the prognostic utility of tauopathy-associated single nucleotide polymorphisms ( SNPs ) in sporadic behavioral-variant frontotemporal dementia ( bvFTD ) .
OBJECTIVE : To determine the rate of long-term cochlear implant ( CI ) use in children.
OBJECTIVE : To determine the relationship between history of cancer and odds of dementia proximate to death and neuropathological indices of AD.
OBJECTIVE : To determine the sensitivity and specificity of apparent age for the detection of poor health status.
OBJECTIVE : To determine the sensitization potential of sunscreen applied immediately after ablative fractional skin resurfacing.
OBJECTIVE : To determine the socio-demographic and health factors associated with a biomedical phenotype of successful aging ( SA ) among Mexican community-dwelling elderly.
OBJECTIVE : To determine the US elasticity of muscles in children at rest and following exercise.
Objective : To determine whether a dual-task gait test is associated with incident dementia in MCI.
OBJECTIVE : To determine whether aerobic exercise training modifies brain energy metabolism in mild AD.
OBJECTIVE : To determine whether and how protease inhibitors ( PIs ) could affect vascular aging.
OBJECTIVE : To determine whether anemia is associated with incident dementia in older adults.
OBJECTIVE : To determine whether biomaterials favor bacterial growth and / or attract bacteria.
OBJECTIVE : To determine whether birth cohort or age was more strongly correlated with total and specific IgE levels.
OBJECTIVE : To determine whether brain activity over the prefrontal cortex measured in real time during walking predicts falls in high-functioning older adults.
Objective : To determine whether BRCA1 and BRCA2 germline mutation status affects therapy response in patients with TNBC.
Objective : To determine whether collaborative care plus @number@ years of home-based occupational therapy delays functional decline.
OBJECTIVE : To determine whether compensatory saccade metrics observed in the video head impulse test , specifically saccade amplitude and latency , predict physical performance.
Objective : To determine whether cortical amyloid burden is associated with greater loneliness in cognitively normal older adults.
OBJECTIVE : To determine whether daily , low-dose aspirin reduces the incidence of cardiovascular events in older Japanese patients with multiple atherosclerotic risk factors.
OBJECTIVE : To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease ( AD ) .
OBJECTIVE : To determine whether inflammatory genetic markers could stratify patients with knee OA into high and low risk for destructive disease.
OBJECTIVE : To determine whether injection every @number@ months with onabotulinumtoxinA provides longer-lasting reduction or elimination of glabellar rhytides.
OBJECTIVE : To determine whether leptin is related to all-cause and cardiovascular ( CV ) mortality in older adults.
OBJECTIVE : To determine whether men with Klinefelter syndrome ( KS ) have the same phenotype as men with mosaic KS.
OBJECTIVE : To determine whether metformin is associated with a lower incidence of dementia than sulfonylureas.
OBJECTIVE : To determine whether musculoskeletal pain was associated with impaired sexual function in a population sample of middle-aged and older men.
OBJECTIVE : To determine whether older adults with diabetes are at increased risk of an injurious fall requiring hospitalization.
OBJECTIVE : To determine whether oral quinacrine increases survival in sporadic Creutzfeldt-Jakob disease ( sCJD ) .
OBJECTIVE : To determine whether PD susceptibility loci are associated with parkinsonism or substantia nigra pathology in a large community-based cohort of older persons.
OBJECTIVE : To determine whether pentosidine contributes to age-related and disease-related impairment of pulmonary functions in patients with asthma.
OBJECTIVE : To determine whether photoaging or natural aging causes a smaller response to a prick-puncture skin test.
OBJECTIVE : To determine whether sleep duration is associated with self-rated health and quality of life in adults residing in New South Wales , Australia.
OBJECTIVE : To determine whether socioemotional disinhibition and executive dysfunction are related to dissociable patterns of brain atrophy in neurodegenerative disease.
OBJECTIVE : To determine whether spatiotemporal gait parameters could predict recurrent falls in elderly women.
Objective : To determine whether testosterone treatment of older men with low testosterone increases volumetric BMD ( vBMD ) and estimated bone strength.
OBJECTIVE : To determine whether the 10-year success rate of penetrating keratoplasty for corneal endothelial disorders is associated with donor age.
OBJECTIVE : To determine whether the QT interval , a marker of ventricular repolarization , could be used to predict incident AF.
OBJECTIVE : To determine whether there is an association between sleep position and the appearance of facial wrinkles and facial descent.
OBJECTIVE : To determine whether the relationship between age and physical and mental health varies by diabetes status in older U.S. adults.
OBJECTIVE : To determine whether the time course for the buildup of auditory stream segregation differs between younger and older adults.
Objective : To determine whether women with germline BRCA mutations have reduced primordial follicle reserve and increased oocyte DNA damage.
OBJECTIVE : To determine which measures-impaired fasting glucose ( IFG ) , elevated HbA1c , or both-best predict incident diabetes in older adults.
OBJECTIVE : To develop a centralized mobile system to conduct elderly frailty assessments in an accurate and objective way using mobile phone capabilities.
OBJECTIVE : To develop a foodservice satisfaction instrument for residential aged care and geriatric / rehabilitation units.
OBJECTIVE : To develop age and sex specific reference intervals of serum lipid parameters in healthy Indian children in the age group of 6-17 years.
OBJECTIVE : To develop and validate a clinical scale for the evaluation of forearm skin aging.
OBJECTIVE : To develop and validate online and telephone-based automated self-tests of cognitive function.
OBJECTIVE : To develop an instrument based on ISTAART-AA MBI criteria.
OBJECTIVE : To develop a photographic scale for grading widening of pores , and to identify the factors associated with pore widening.
OBJECTIVE : To develop a practical photonumeric scale that respects the complex anatomy and age-related changes occurring in the orbital area.
OBJECTIVE : To develop consensual practice recommendations for treating the aging upper- and mid-face with onabotulinum.
OBJECTIVE : To develop recommendations for a core outcome set ( COS ) of standing balance measures for research and practice among adults.
OBJECTIVE : To discuss the aetiology , clinical features , diagnosis and management of androgen deficiency in the aging man.
OBJECTIVE : To discuss the anatomic features , clinical presentations , diagnosis , differentiations and treatments of congenital fourth branchial anomaly ( CFBA ) .
OBJECTIVE : To discuss the early clinical results and risk factors of modified Colonna capsular arthroplasty for young patients with unilateral hip dislocation.
OBJECTIVE : To discuss the effectiveness of distal palm perforator mini-flap in the treatment of scar contracture of digital web-spaces.
OBJECTIVE : To discuss the presentation , pathophysiology , and optimal treatment of hypertension among elderly persons.
OBJECTIVE : To discuss the surgical option and the treatment of complications of pancreatic cystic tumors.
OBJECTIVE : To document values for parameters of global spinal balance in @number@ asymptomatic adults without spinal pathology.
OBJECTIVE : To elucidate the effect of PlGF on hair growth.
OBJECTIVE : To elucidate the etiology of acute respiratory tract infection ( ARI ) in hospitalized children in Suzhou from @number@ to @number@
OBJECTIVE : To elucidate the kinematic relationships of the upper cervical spine.
OBJECTIVE : To enhance knowledge and understanding of the laryngeal framework maturation in different age groups and genders.
OBJECTIVE : To establish a preliminary magnetic resonance imaging ( MRI ) database of whole spine of healthy Chinese adolescents.
OBJECTIVE : To estimate and project the number of people affected worldwide by giant cell arteritis ( GCA ) by @number@
OBJECTIVE : To estimate associations of progestin-only contraceptives with persistent pelvic girdle pain @number@ months after delivery.
OBJECTIVE : To estimate mortality rate by external causes in Brazil.
OBJECTIVE : To estimate risk and duration of chronic conditions and disability for all older Americans and demographic subgroups.
OBJECTIVE : To estimate the contributions of biological aging , historical trends , and birth cohort effects on trends in pre-eclampsia in the United States.
OBJECTIVE : to estimate the determinants of individual out-of-pocket health expenditure in China.
OBJECTIVE : To estimate the duration of moderate-to-severe menopausal hot flushes and identify potential risk factors for hot flush duration.
OBJECTIVE : To estimate the effect of current colonoscopy use on CRC mortality and its further potential in reducing CRC mortality.
OBJECTIVE : To estimate the global burden of neck pain.
OBJECTIVE : To estimate the incidence of and to characterize cognitive and imaging findings associated with incident amyloid PET positivity.
OBJECTIVE : To estimate the incidence of psychotic symptoms in Alzheimer's disease.
OBJECTIVE : To estimate the incidence of traffic accidents and find related factors among the older population.
OBJECTIVE : • To estimate the magnitude of increase in prostate cancer cases diagnosed in Canada by the year @number@
OBJECTIVE : To estimate the prevalence and patterns of use of PPMs and to measure the quality of PPM use.
OBJECTIVE : To estimate the prevalence of depression and determine the factors associated with it in older Indians aged @number@ years and above.
OBJECTIVE : To estimate the prevalence of elevated brain amyloid and reduced cortical thickness ( as a marker for neurodegeneration ) in a defined population.
OBJECTIVE : To estimate the prevalence of obstructive pattern on spirometry in a representative sample of adults from Porto , Portugal.
OBJECTIVE : To estimate the prevalence of PIDPs and the association with adverse outcomes in NH residents.
OBJECTIVE : To estimate the risk of hospitalization for stroke in elderly users of antipsychotics.
OBJECTIVE : To estimate the value of the different thromboelastogram indices for predicting hemorrhage and vascular obstruction in an elderly population.
OBJECTIVE : To evaluate 12-month effectiveness and safety of VYC-17.5L for the treatment of moderate / severe nasolabial folds ( NLFs ) .
OBJECTIVE : To evaluate associations among phase angle , frailty and mortality.
OBJECTIVE : To evaluate available evidence on multicomponent nonpharmacological delirium interventions in reducing incident delirium and preventing poor outcomes associated with delirium.
OBJECTIVE : To evaluate causes and clinical management of postoperative pain after total knee arthroplasty ( TKA ) .
OBJECTIVE : To evaluate fMRI whole-brain resting-state functional connectivity changes in relation to cognitive decline in Parkinson disease ( PD ) over a 3-year period.
OBJECTIVE : To evaluate intervention effects on tertiary physical performance outcomes.
OBJECTIVE : To evaluate lactation duration in relation to subsequent atherosclerosis in women during midlife.
OBJECTIVE : To evaluate patient characteristics associated with receipt of testosterone.
OBJECTIVE : To evaluate psychological and demographic aspects of men who received DRE during the PCa screening in an outpatient clinical setting.
OBJECTIVE : To evaluate safety and effectiveness of supraorbital keyhole approach to the sella and anterior skull base via a forehead wrinkle incision.
OBJECTIVE : To evaluate skin laxity effects of microneedle fractional radiofrequency induced thermal lesions in different dermal layers.
OBJECTIVE : To evaluate the association between abnormal AAI with MBD and inflammation in patients on HD.
OBJECTIVE : To evaluate the association between overweight and abdominal obesity with all-cause and cardiovascular mortality in the elderly aged @number@ and over.
OBJECTIVE : To evaluate the association between self-reported daily sitting time and the incidence of type @number@ diabetes in a cohort of postmenopausal women.
OBJECTIVE : To evaluate the association between telomere length ( TL ) and adiposity markers in overweight / obese adolescents after an intensive program.
OBJECTIVE : To evaluate the association between thoracic kyphosis and physical function.
OBJECTIVE : To evaluate the association of early-adulthood and mid-adulthood hypertension with dementia in men and women.
OBJECTIVE : To evaluate the association of early-onset AGA and metabolic syndrome in Thai male patients.
Objective : To evaluate the association of measured and self-reported visual impairment ( VI ) with cognition in older US adults.
Objective : To evaluate the association of TSH and FT4 with incident fractures in euthyroid individuals.
OBJECTIVE : To evaluate the benefits of PRP in the wound healing process after FxCR.
OBJECTIVE : To evaluate the brain morphometry of AD patients at all disease stages , identifying the structural neuro-degeneration profile associated with AD severity.
OBJECTIVE : To evaluate the clinical efficacy of combination therapy of intradermal RF and HA filler for nasolabial fold ( NLF ) wrinkle reduction.
OBJECTIVE : To evaluate the collagen- and elastin-stimulating effects of diluted CaHA in subjects with skin laxity in the neck and décolletage.
OBJECTIVE : To evaluate the complications reported after treatment with polyalkylimide.
OBJECTIVE : To evaluate the correlation between chronological and biological age by comparing the normograms of AFC , AMH , and FSH.
OBJECTIVE : To evaluate the correlation between lower urinary tract symptoms , erectile dysfunction , and cardiovascular diseases in different male populations.
OBJECTIVE : To evaluate the distribution , clinical features , and outcomes of nephropathies diagnosed by biopsy in the elderly.
OBJECTIVE : To evaluate the effectiveness of Varenicline for smoking cessation in a community-based smoking-cessation-clinic ( SCC ) in Chinese smokers.
OBJECTIVE : To evaluate the effect of amyloid imaging on clinical decision making.
OBJECTIVE : To evaluate the effect of blood storage duration on postoperative morbidity and mortality in children undergoing cardiac surgery.
OBJECTIVE : To evaluate the effect of diabetes by gender on the peak-risk of first-ever-ischemic stroke and its recurrence.
OBJECTIVE : To evaluate the effect of individually tailored dietary counseling on nutritional status among home care clients aged @number@ years or older.
OBJECTIVE : To evaluate the effect of introducing primary care patients to a free smartphone app for weight loss.
OBJECTIVE : To evaluate the effects of age on hip proprioception , and determine whether age-related hip proprioception declines disrupt balance.
OBJECTIVE : To evaluate the effects of case management in community aged care ( CMCAC ) interventions on service use and costs.
OBJECTIVE : To evaluate the effects of intraoral aging on surface properties of esthetic and conventional nickel-titanium ( NiTi ) archwires.
OBJECTIVE : To evaluate the effects of simulated aging in bond strength and nanoleakage of class II restorations using three different restorative techniques.
OBJECTIVE : To evaluate the effects of swimming on upper extremity motor control , and balance in elderly population.
Objective : To evaluate the effects of testosterone replacement on corrected QT interval ( QTcF ) in two randomized controlled trials.
OBJECTIVE : To evaluate the efficacy and safety of ALA-IPL PDT for photoaging in Chinese subjects with Fitzpatrick skin types III and IV.
OBJECTIVE : To evaluate the efficacy and safety of a novel @number@ , 927-nm fractional thulium fiber laser in the treatment of nonfacial photodamage.
OBJECTIVE : To evaluate the efficacy and safety of onabotulinumtoxinA treatment of CFL.
OBJECTIVE : To evaluate the efficacy and safety of onabotulinumtoxinA treatment of CFL alone or with glabellar lines ( GL ) .
OBJECTIVE : To evaluate the efficacy and safety of subdermal minimal surgery technology in the treatment of horizontal neck wrinkles.
OBJECTIVE : To evaluate the efficacy and safety of testosterone undecanoate ( TU ) in the treatment of late-onset hypogonadism ( LOH ) by meta-analysis.
OBJECTIVE : To evaluate the efficacy of adhesive tape for temporary management of inturned upper eyelid eyelashes.
OBJECTIVE : To evaluate the episodic migraine ( EM ) -obesity association and the influence of age , race , and sex on this relationship.
OBJECTIVE : To evaluate the feasibility and short- and long-term effects of two 10-wk structured ergometer-cycling programs among elderly in assisted-living residences.
OBJECTIVE : To evaluate the impact of DAPs on hospitalization and mortality in older patients with stable cardiovascular disease ( CVD ) .
OBJECTIVE : To evaluate the impact of varying levels of alcohol consumption on depressive symptoms over time in patients with and without HIV infection.
OBJECTIVE : To evaluate the influence of different cement combinations on coronal microleakage in restored endodontically treated teeth using dye penetration.
OBJECTIVE : To evaluate the in vivo relevance of the inhibitory effect of tenofovir on telomerase activity observed in vitro.
OBJECTIVE : To evaluate the long-term trend of cataract prevalence and the effect of prevention and treatment blindness in Zhejiang Province.
OBJECTIVE : To evaluate the need for pharmaceutical care implementation in institutionalized , polymedicated elderly.
OBJECTIVE : To evaluate the prevalence of frailty and the associated multimorbidity and functional impairments among community-dwelling middle-aged and elderly people in Taiwan.
OBJECTIVE : To evaluate the prevalence of leisure-time physical activity and sedentary behaviors among Chinese floating population aged 18-59.
OBJECTIVE : To evaluate the relation between vitamin D nutritional status and muscle function and muscle strength in women aged over @number@ years.
OBJECTIVE : To evaluate the relationship between frailty and taste and smell perception in elderly people living in urban areas.
OBJECTIVE : To evaluate the relationship between isokinetically and isometrically determined muscle strength and BMD in postmenopausal women of different age groups.
OBJECTIVE : To evaluate the safety and efficacy of a @percent@ polyacrylamide hydrogel in the aesthetic enhancement of nasolabial folds.
OBJECTIVE : To evaluate the safety and efficacy of a single intravenous bolus of epoetin alfa in patients with STEMI.
OBJECTIVE : To evaluate the safety and efficacy of full-face treatments with various total doses of abobotulinum toxin A ( ABO ) .
OBJECTIVE : To evaluate the safety , clinical , and cost impact of discontinuing statin medications for patients in the palliative care setting.
OBJECTIVE : To evaluate the STOP™ home-use device for facial skin tightening using objective and subjective methods.
OBJECTIVE : To evaluate the temporal association between depression symptoms and cognitive function in older adults over a 4-year period.
OBJECTIVE : To evaluate the time-course modification of suboptimal prescribing in older , community dwellers.
OBJECTIVE : To evaluate the type and frequency of self-mutilation lesions of the mouth and lips in a large group of institutionalized mentally retarded subjects.
OBJECTIVE : To evaluate the use of a short questionnaire to assess diet quality in older adults.
OBJECTIVE : To evaluate the utility of routine hormone evaluation in all men presenting for infertility by understanding the relationship between sperm concentration and hypoandrogenism.
OBJECTIVE : To evaluate whether age-related changes in vestibular evoked myogenic potentials ( VEMPs ) differ by demographic and cardiovascular risk groups.
OBJECTIVE : To evaluate whether alcohol drinking influences emergency room ( ER ) visits or hospital admissions among adults aged @number@ and older.
OBJECTIVE : To evaluate whether aligning the Part D low-income subsidy and Medicaid program enrollment pathways in @number@ increased Medicaid participation among new Medicare beneficiaries.
OBJECTIVE : To evaluate whether long-term multivitamin supplementation affects cognitive health in later life.
OBJECTIVE : To evaluate whether prenatal DHA supplementation increases gestational age and birth size.
OBJECTIVE : To evaluate whether the efficacy and safety of menatetrenone for the treatment of osteoporosis is noninferior to alfacalcidol in Chinese postmenopausal women.
OBJECTIVE : To examine age-related differences in the relationship between personality and coping strategies in an Australian population of psychiatric inpatients.
OBJECTIVE : To examine and describe regional variation in outcomes for persons with stroke receiving inpatient medical rehabilitation.
OBJECTIVE : To examine associations between audiological and non-audiological factors and successful hearing aid use in older adults.
OBJECTIVE : To examine associations between complexity of main lifetime occupation and cognitive performance in later life.
OBJECTIVE : To examine associations between ischemic stroke , vascular risk factors , and MRI markers of brain aging.
OBJECTIVE : To examine associations between menopausal status and physical performance in middle-aged women from the Northeast region of Brazil.
Objective : To examine associations between SCD and global Aβ and tau burdens in regions of interest in clinically healthy older adults.
OBJECTIVE : To examine baseline prestroke weight loss and poststroke mortality among men.
OBJECTIVE : To examine basic and everyday cognitive predictors of older adults ' self-reported instrumental activities of daily living ( IADL ) .
OBJECTIVE : To examine changes in the prevalence of mobility limitations and mobile life expectancy of Singaporeans aged 55 + .
OBJECTIVE : To examine differences in treatment decision-making participation , satisfaction , and regret among Latinas and non-Latina whites with DCIS.
OBJECTIVE : To examine effect modification between genetic susceptibility to age-related macular degeneration ( AMD ) and dietary antioxidant or fish consumption on AMD risk.
OBJECTIVE : To examine evolving patterns of depression diagnosis and treatment in older U.S. adults in the era of newer-generation antidepressants.
OBJECTIVE : To examine how presentation of different stimuli impacts affect in nursing home residents with dementia.
OBJECTIVE : To examine how the associations of chronic disease and impairment with specific disability have changed over time.
OBJECTIVE : To examine older adults ' attitudes toward multifunctional technology tools and specific preferences and expectations that would maximize their utility and usability.
Objective : To examine patterns of neurodegeneration in individuals with SNAP compared with their Aβ + counterparts.
OBJECTIVE : To examine physical activity ( PA ) prevalence in individuals with arthritis in comparison with those with other chronic diseases.
OBJECTIVE To examine relationships between Aβ and non-Aβ factors as well as neurodegeneration within AD regions in cognitively normal older adults.
OBJECTIVE : to examine relationships between diet and physical performance in community-dwelling older men and women.
OBJECTIVE : To examine spousal associations between functional limitation and depressive symptom trajectories in a national sample of older long-term married couples.
OBJECTIVE : To examine the ability of clinic-based assessments of gait speed to capture limitations in a broad range of home- and community-based activities.
OBJECTIVE : To examine the accuracy of individual Fried frailty phenotype measures in identifying the Fried frailty phenotype in primary care.
OBJECTIVE : To examine the additive effect of age on disability for adults with spinal cord injury ( SCI ) .
OBJECTIVE : To examine the aesthetics of the upper eyelid , lower eyelid , lateral canthus , and brow with respect to male periorbital rejuvenation.
OBJECTIVE : To examine the association between alcohol consumption in midlife and subsequent cognitive decline.
Objective : To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease ( CVD ) in a case-cohort setting.
OBJECTIVE : To examine the association between co-morbidities and the use of antidiabetic medications or adjunctive cardiovascular medicines among Australian veterans with diabetes.
OBJECTIVE : To examine the association between depressive symptoms and functional status in elderly people living in an urban center in northeastern Brazil.
OBJECTIVE : To examine the association between dietary patterns in midlife and prevalence of healthy aging.
Objective : To examine the association between dietary vitamin K1 intake and the risk of incident cataracts in an elderly Mediterranean population.
OBJECTIVE : To examine the association between perceived environmental barriers to and facilitators for outdoor mobility with life-space among older people.
OBJECTIVE : To examine the association between SBP and HF risk in the elderly.
OBJECTIVE : To examine the association between the American Heart Association ( AHA ) Life's Simple @number@ ( LS7 ) metric and brain structure.
OBJECTIVE : To examine the association between walnut consumption and measures of cognitive function in the US population.
OBJECTIVE : To examine the association of brain DNA methylation in @number@ reported AD loci with AD pathologies.
OBJECTIVE : To examine the association of cognitive function with the risk of incident mobility impairments and the rate of declining mobility in older adults.
OBJECTIVE : To examine the association of dietary habits with high total antioxidant capacity ( TAC ) with frailty among elderly Japanese women.
OBJECTIVE : To examine the association of dietary sodium intake with cognitive function in community-dwelling older adults.
Objective : To examine the association of mental disorders and psychotropic medication use with osteoporotic fracture risk in routine clinical practice.
OBJECTIVE : To examine the association of @number@ established PCa risk single-nucleotide polymorphisms ( SNPs ) with PCSM.
OBJECTIVE : To examine the association of patient- and medication-related factors with postdischarge medication errors.
Objective : To examine the association of weight gain from early to middle adulthood with health outcomes later in life.
OBJECTIVE : To examine the associations between ADHD and social functioning and participation among older adults.
OBJECTIVE : To examine the associations of foot posture and foot function to foot pain.
OBJECTIVE : To examine the characteristics of auditory verbal hallucinations and associated factors in older adults with schizophrenia.
OBJECTIVE : To examine the cross-sectional and longitudinal associations between benzodiazepine use and daily activity limitations , according to drug indications and duration of action.
OBJECTIVE : To examine the differences in dietary intake by different living situations in elderly Japanese people.
OBJECTIVE : To examine the effect of donor age and other perioperative factors on long-term endothelial cell loss after penetrating keratoplasty ( PKP ) .
OBJECTIVE : To examine the effect of preoperative impaired sensorium ( IS ) on general surgical outcomes.
OBJECTIVE : To examine the effects of a greens alkalizing dietary supplement on urinary pH levels in individuals with lower-than-average pH levels.
OBJECTIVE : To examine the effects of electronic health information technology ( HIT ) on nursing home residents.
OBJECTIVE : To examine the effects of food groups and dietary nutrients on bone loss in elderly Chinese population.
OBJECTIVE : to examine the effects of physical rehabilitation on activities of daily living ( ADL ) in elderly residents of long-term care facilities.
OBJECTIVE : To examine the effects of pre-pregnancy alcohol drinking on child neuropsychological functioning.
OBJECTIVE : To examine the efficacy of cognitive speed of processing training ( SOPT ) among individuals with Parkinson disease ( PD ) .
OBJECTIVE : To examine the expected public health impact , budget impact , and incremental cost-effectiveness of QIV versus TIV in the United States.
OBJECTIVE : To examine the experiences of primary care consultation among older adults with symptomatic foot osteoarthritis ( OA ) .
OBJECTIVE : To examine the extent to which socio-demographics , modifiable lifestyle , and physical health status influence the mental health of post-menopausal Australian women.
OBJECTIVE : To examine the hypothesis that DTD might inhibit TNF-α-induced ICAM-1 expression through regulating the expression of p53 and p21.
OBJECTIVE : To examine the impact of out-migration on Kenya's nursing workforce.
OBJECTIVE : To examine the impact of varying decision criteria on neuropsychological diagnostic frequencies and on their correlates.
OBJECTIVE : To examine the influence of audiological and non-audiological factors on help-seeking for hearing impairment ( HI ) in older adults.
OBJECTIVE : To examine the influences of sex , height , and age on spatiotemporal metrics during non-pathological gait over the course of adult aging.
OBJECTIVE : To examine the longitudinal association between changes in health behaviors and depression and determine the mediating effect of health characteristics on this association.
OBJECTIVE : To examine the old-age consequences of international migration with a focus on disability and wealth from the perspective of the origin country.
OBJECTIVE : To examine the perspectives of youth on factors that influence mental health service use after aging out of foster care.
OBJECTIVE : To examine the possible influence of cognitive ability and education at age @number@ or @number@ on number of teeth at age @number@
OBJECTIVE : To examine the possible relationship between height loss and future CHD.
OBJECTIVE : To examine the potential effectiveness of a television ( TV ) campaign to increase seasonal influenza vaccination among the elderly.
OBJECTIVE : to examine the predictive power of the TMT for on-road driving performance.
OBJECTIVE : To examine the prospective relation between animal companionship and biomarkers of ageing in older people.
OBJECTIVE : To examine the relation of cerebral amyloid angiopathy ( CAA ) to cognitive domains in older community-dwelling persons with and without dementia.
OBJECTIVE : To examine the relationship between body weight status and onset of functional limitations in U.S. middle-aged and older adults.
OBJECTIVE : to examine the relationship between combined lifestyle behaviours and quality-adjusted life years ( QALYs ) in a general population.
OBJECTIVE : To examine the relationship between measures of sleep quality and the presence of commonly encountered comorbid and sociodemographic conditions in elderly Black subjects.
OBJECTIVE : To examine the relationship between regional and whole body fat accumulation and core cognitive executive functions.
OBJECTIVE : To examine the relationship between task switching and thought suppression in connection with frontal lobe epilepsy ( FLE ) .
OBJECTIVE : to examine the relationship between telomere length and marital status in a sample of middle-aged adults.
OBJECTIVE : To examine the relationships among health behaviors in older persons and whether they form related groups of behaviors.
OBJECTIVE : To examine the relationships between smoking status and various domains of cognitive function in community-dwelling elderly subjects.
OBJECTIVE : To examine the risk factors for photoaging in a Queensland community.
OBJECTIVE : To examine the role of health conditions , socioeconomic , and socioenvironmental factors in explaining gender differences in physical disability among older adults.
OBJECTIVE : To examine the synergistic effect of interaction between perceived health and social activity on depressive symptoms.
OBJECTIVE : To examine the use of antimuscarinics for treating urinary incontinence ( UI ) in older adults with varying levels of cognition.
OBJECTIVE : To examine the utilization of anticholinergic medications and factors associated with anticholinergic medication use in elderly nursing home patients with dementia.
OBJECTIVE : To examine the variability in performance among placebo groups in randomized controlled trials for mild cognitive impairment ( MCI ) .
OBJECTIVE : To examine uniformity of HA structure , the effects of extrusion , and lidocaine dilution of @number@ commercially available HA soft-tissue fillers.
OBJECTIVE : To examine whether adherence to the Mediterranean diet was associated with longer telomere length , a biomarker of aging.
Objective : To examine whether a modified Hospital Elder Life Program ( mHELP ) reduces incident delirium and LOS in older patients undergoing abdominal surgery.
OBJECTIVE : To examine whether a set of well-known predictors of mortality in younger elderly also maintain their importance in Chinese oldest old group.
OBJECTIVE : To examine whether certain personal and workplace factors increase risk for work-related injuries among home health aides.
OBJECTIVE : To examine whether consistent low-risk drinking is associated with lower risk of developing functional limitations among older adults.
OBJECTIVE : To examine whether effects of dementia severity on Medicare expenditures differed for individuals with different levels of comorbidities.
OBJECTIVE : To examine whether established diabetes risk factors and diabetes risk algorithms are associated with future frailty.
OBJECTIVE : To examine whether fractional nonablative laser resurfacing induces skin tightening.
Objective : To examine whether fracture prediction by FRAX® is affected by hip area.
OBJECTIVE : to examine whether frailty assessment differs when we construct frailty indices using solely self-reported or test-based health measures.
OBJECTIVE : To examine whether HGS predicts disability in older women with acute low back pain ( LBP ) .
OBJECTIVE : To examine whether long-term measures of cortisol predict Alzheimer disease ( AD ) risk.
OBJECTIVE : To examine whether religiousness mediates the relationship between sociodemographic factors , multimorbidity and health-related quality of life of older adults.
OBJECTIVE : To examine whether self-regulation is associated with reduced risk of coronary heart disease ( CHD ) .
OBJECTIVE : To examine whether stroke survivors with more severe spatial neglect during their acute inpatient rehabilitation had poorer mobility after returning to their communities.
OBJECTIVE : To examine whether the apolipoprotein E ( APOE ) ε4 allele modifies the association of neighborhood psychosocial hazards and cognitive function.
OBJECTIVE : To examine whether the association between APOE and PS is mediated by white matter microstructure in very old persons without dementia.
OBJECTIVE : To explore adherence to physical activity recommendations in older adults in Israel.
OBJECTIVE : To explore angioarchitectural features of brain arteriovenous malformations ( BAVMs ) in ages.
OBJECTIVE : To explore associated proteins involved in age-related changes of the testis and better understand the roles of these proteins in the human testis.
OBJECTIVE : To explore associations between older adults ' communicative difficulties , depressive symptoms , and e-mail and telephone use with adult children.
OBJECTIVE : To explore caregivers ' challenges and quality-of-life issues managing diabetes in patients with dementia.
OBJECTIVE : To explore Chinese medicine syndrome distribution laws of asymptomatic HIV infection patients.
OBJECTIVE : To explore cohort effects on age- and Alzheimer disease ( AD ) -related neuropathologic changes.
OBJECTIVE : To explore factors that influence how informal caregivers manage medications as part of caring for hospice patients.
OBJECTIVE : To explore individual-level EoL trajectories in the Israeli population.
OBJECTIVE : To explore seroepidemiological status and vaccine coverage of hepatitis B in children aging under @number@ years old in Chaoyang district of Beijing.
OBJECTIVE : To explore the anti-aging effects of mild-warming moxibustion on Bcl-2 and PKC expression in peripheral blood and general symptoms in elderly people.
OBJECTIVE : To explore the association between baseline life-space mobility and nursing home ( NH ) admission among community-dwelling older adults over @number@ years.
OBJECTIVE : To explore the association between body mass index ( BMI ) and all-cause mortality among the elderly in Beijing.
OBJECTIVE : To explore the association between use of sedative drugs and frailty.
OBJECTIVE : To explore the associations between social networks , social contacts , and cognitive impairment in the very elderly aged 90-108 years.
OBJECTIVE : To explore the basic syndrome related factors in patients with chronic prostatitis ( CP ) .
OBJECTIVE : To explore the cognitive function status and potential influence factors on cognitive function in hospitalized patients with chronic heart failure.
OBJECTIVE : To explore the distribution characteristics of basic syndromes and its related factors in patients with chronic functional constipation ( CFC ) .
OBJECTIVE : To explore the effect of multimorbidity patterns on mortality for all causes at 3- and 5-year follow-up periods.
OBJECTIVE : to explore the existence of alternative views on oral health through values , beliefs and behaviors of older adults.
OBJECTIVE : To explore the influence of moxibustion at Shenque ( CV @number@ ) point on aging and its mechanism.
OBJECTIVE : To explore the likely impact of future trajectories of morbidity and mortality in Australia.
OBJECTIVE : To explore the mechanism of bakuchiol on anti-aging gene mRNA expression level of human skin fibroblasts ( ESF-1 ) .
OBJECTIVE : To explore the mechanism of electroacupuncture of \ "Shuanggu Yitong \ " prescription on postponing aging.
OBJECTIVE : to explore the perspectives of health professionals regarding barriers to optimal palliative care for older people in acute hospitals.
OBJECTIVE : To explore the prevalence and its influencing factors on mental disorders in older people after falling in a community from Guangzhou city.
OBJECTIVE : To explore the relationship between chronic prostatitis ( CP ) and prostatic calculus ( PC ) .
OBJECTIVE : To explore the relationship between resilience and rehabilitation outcomes in older orthopaedic patients.
OBJECTIVE : To explore the role of working conditions in the association between socioeconomic position and health after retirement age using over @number@ years follow-up.
OBJECTIVE : To explore the trend and characteristics of cardiovascular disease mortality in China.
OBJECTIVE : To explore the trends of vitamin intake over a 10-year follow-up in a group of successfully aging elderly people.
OBJECTIVE : To explore what older people with sight impairment believe to be the causes of falls.
OBJECTIVE : To explore workers ' opinions about the effectiveness of contact with health care providers in shortening sickness absence duration.
OBJECTIVE : To find out the prevalence of Psychiatric Morbidity Among Elderly in the age-group of @number@ years and above.
OBJECTIVE : To further evaluate the safety and effectiveness of MFU-V for improving lines and wrinkles of the décolleté in a larger patient population.
OBJECTIVE : To gain insight into the potential mechanism of mitochondria dysfunction in pathogenesis , progression and therapeutic management of glaucoma.
OBJECTIVE : To generate estimates of the association between markers of ovarian aging and natural fertility in a community sample at risk for ovarian aging.
OBJECTIVE : To help family physicians better recognize frailty and its implications for managing elderly patients.
OBJECTIVE : To histologically analyze chronologic and quantitative change in collagens after mRF treatment to determine the mechanisms of the antiaging effect.
OBJECTIVE : To identify age-related changes in human meibomian glands that may be associated with meibomian gland dysfunction ( MGD ) .
OBJECTIVE : To identify Alzheimer's disease ( AD ) severity measures for use in cost-effectiveness models that effectively capture the impact of AD on costs.
OBJECTIVE : To identify and classify glabellar wrinkle patterns in Koreans for a better treatment approach.
OBJECTIVE : To identify and synthesise the range of barriers and facilitators to physical activity participation.
OBJECTIVE : To identify a set of clinically useful outcome measures for assessment of adults receiving treatment for spasticity.
OBJECTIVE : To identify barriers to sleep for intensive care unit ( ICU ) patients.
OBJECTIVE : To identify clinical and demographic factors predictive of midurethral sling failure.
OBJECTIVE : To identify clinical , laboratorial and radiographic predictors for Bordetella pertussis infection.
OBJECTIVE : to identify cognitive changes associated with an increased risk of 2-year incident dementia using the Cambridge Cognitive Examination ( CAMCOG ) .
OBJECTIVE : To identify common genetic variants that influence fish and dietary eicosapentaenoic acid plus docosahexaenoic acid ( EPA + DHA ) consumption.
OBJECTIVE : To identify distinct disability trajectories from admission to one-year post-discharge in acutely hospitalized older patients after hip fracture.
OBJECTIVE : To identify early changes in brain structure and function that are associated with cardiovascular risk factors ( CVRF ) .
OBJECTIVE : To identify exposures possibly contributing to anemia cases among hexavalent chromium medical surveillance program enrollees.
OBJECTIVE : To identify facility and market factors affecting transitions of nursing home residents back to the community.
OBJECTIVE : to identify factors associated with FOF.
OBJECTIVE : To identify factors associated with late-life longitudinal change in AEE.
OBJECTIVE : To identify factors associated with the risk , onset , and persistence of post-dural puncture headache ( PDPH ) .
OBJECTIVE : To identify forms of abuse and ill-treatment in the elderly , as well as the determinants of these abuses.
OBJECTIVE : To identify genetic determinants of CHD that are specific to patients with diabetes.
OBJECTIVE : To identify genetic variants that alter susceptibility to myasthenia gravis , we performed a genome-wide association study.
OBJECTIVE : To identify low-frequency coding variants that affect susceptibility to AD , FTD , and PSP.
OBJECTIVE : To identify nutritional needs in various groups of older individuals and to present the nutritional guidelines for older people in Finland.
OBJECTIVE : To identify osteoarthritis ( OA ) progression-modulating pathways in articular cartilage and their respective regulatory epigenetic and genetic determinants in end-stage disease.
OBJECTIVE : To identify phenotypes of adult rhinitis using an unsupervised approach ( data-driven ) compared with a classical hypothesis-driven approach.
OBJECTIVE : To identify potentially modifiable risk factors associated with increased markers of brain oxidative stress.
OBJECTIVE : To identify predictors of long-term motor and cognitive outcomes and rate of progression in PD.
OBJECTIVE : To identify prognostic markers associated with poor recovery from mild traumatic brain injury ( MTBI ) in older adults.
OBJECTIVE : To identify regional brain metabolic dysfunctions associated with neuropsychiatric symptoms ( NPS ) in preclinical Alzheimer disease ( AD ) .
OBJECTIVE : To identify risk factors for idiopathic intracranial hypertension ( IIH ) in men.
OBJECTIVE : To identify salient characteristics of frailty that increase risk of death in depressed elders.
OBJECTIVE : to identify sensorimotor and psychosocial determinants of 3-year incident mobility disability.
OBJECTIVE : To identify some areas in which descriptions of lasers , lights , and energy devices can be improved.
OBJECTIVE : To identify the baseline motor characteristics of the patients who responded to @number@ prominent intervention programs.
OBJECTIVE : To identify the characteristics and clinical aspects of spinal cord injury ( SCI ) in the elderly.
OBJECTIVE : To identify the components of the neuroticism trait most responsible for its association with cognitive decline and dementia in old age.
OBJECTIVE : To identify the factors associated with 3-month PSCI.
OBJECTIVE : To identify the genetic cause for a novel form of pure autosomal dominant HSP.
OBJECTIVE : To identify the immunohistochemical similarities and differences in melanocyte distribution between LM and LMM and chronically sun-exposed skin.
OBJECTIVE : To identify the most predictive and efficient screening tool for frailty.
OBJECTIVE : To identify the neuromuscular attributes that are associated with self-reported mobility status among older primary care patients.
OBJECTIVE : To identify the physical environmental determinants that influence PA across the life course.
OBJECTIVE : To identify the prevalence of depressive symptoms and associated factors in elderly.
OBJECTIVE : To identify the range of glycemic levels associated with the lowest rates of complications and mortality in older diabetic patients.
OBJECTIVE : To identify the shared neuroimaging signature of gait slowing and cognitive impairment.
OBJECTIVE : to identify the socio-demographic , social connectedness , physical environment and physical and mental health-related factors associated with PA.
OBJECTIVE : To implement a sustainable collaborative dementia care program in a public health care system in Indianapolis.
OBJECTIVE : To Improve the diagnosis of duodenal ulcer and preneoplastic changes of gastroduodenal transition.
OBJECTIVE : To improve understanding of the clinical , radiological and pathological characteristics of acute fibrinous and organizing pneumonia ( AFOP ) .
OBJECTIVE : To introduce the Multi-state Markov model in studying the outcome prediction of mild cognitive impairment ( MCI ) .
OBJECTIVE : To investigate age trends , sex differences , and splitting of alpha peaks of the EEG spectrum in the healthy population.
OBJECTIVE : To investigate a pathological continuity between FTLD-TDP and ALS by comparing their respective neuropathological changes in the motor neuron system.
OBJECTIVE : To investigate associations between daily n-3 PUFA intake and the severity of skin photoaging.
OBJECTIVE : To investigate causal factors of functional impairment in old age in a longitudinal approach.
OBJECTIVE : To investigate changes of GAGs during intrinsic aging and photoaging of human skin and their correlations with water content.
OBJECTIVE : To investigate cross-sectionally whether frailty is associated with cognitive impairment or clinically diagnosed dementia in older people.
OBJECTIVE : To investigate factors associated with absence of osteoarthritis ( OA ) .
OBJECTIVE : To investigate functionally important transcripts in single human oocytes with the use of NanoString technology and determine whether observed differences are biologically meaningful.
OBJECTIVE : To investigate how interpersonal traits change as a function of degenerative brain disease type and severity.
OBJECTIVE : To investigate how visual impairment affects social ties in late life longitudinally.
OBJECTIVE : To investigate in vivo the impact of age on nigrostriatal dopamine dysfunction in Parkinson's disease ( PD ) .
OBJECTIVE : To investigate olfaction in relation to incident Parkinson disease ( PD ) in US white and black older adults.
OBJECTIVE : To investigate oxidative stress , hemoglobin percentage and erythrocyte osmotic fragility in various aging groups.
OBJECTIVE : to investigate prospectively the relationship between current alcohol consumption ( quantity and type of alcohol ) and incident overall dementia and Alzheimer dementia.
OBJECTIVE : To investigate the age differences in the risk of diabetes incidence according to body mass index ( BMI ) .
OBJECTIVE : To investigate the age-related associations of work over-commitment with zest for work.
OBJECTIVE : To investigate the aging features of pure leukoaraiosis ( LA ) in non-demented outpatients.
OBJECTIVE : To investigate the anti-aging effect of ginsenoside R1 in serial transplantation of hematopoietic stem cells and progenitor cells.
OBJECTIVE : To investigate the association between age at menarche and age at menopause among Brazilian women.
OBJECTIVE : to investigate the association between alcohol consumption and physical limitations in Eastern European populations.
OBJECTIVE : To investigate the association between nutritional status and functional limitation and disability in an elderly population in southern Brazil.
OBJECTIVE : To investigate the association between self-reported supplementary calcium consumption and the prevalence of AMD in a representative US sample.
OBJECTIVE : To investigate the association between subclinical thyroid dysfunction and bone loss.
OBJECTIVE : To investigate the association between visit-to-visit variability in blood pressure and cognitive function in old age ( > 70 years ) .
OBJECTIVE : To investigate the association of age with potential drug-drug interactions ( PDDIs ) involving ARVs.
Objective : To investigate the association of frailty syndrome with socioeconomic and health variables among older adults.
OBJECTIVE : To investigate the association of orthostatic hypertension and hypotension with hypertensive target organ damage in middle and old-aged hypertensive patients.
OBJECTIVE : To investigate the association of socio-demographic indicators with regular smoking initiation among adults.
OBJECTIVE : To investigate the association of type @number@ diabetes with subcortical infarctions.
OBJECTIVE : To investigate the associations between age , vascular health , and Alzheimer disease ( AD ) imaging biomarkers in an elderly sample.
OBJECTIVE : To investigate the associations between VDR gene variants and mortality among older people.
OBJECTIVE : To investigate the associations of metformin , serum vitamin B12 , calcium supplements , and cognitive impairment in patients with diabetes.
OBJECTIVE : To investigate the associations of overweight and obesity with longitudinal decline in physical functioning ( PF ) among middle-aged and older Russians.
OBJECTIVE : To investigate the associations of serum vitamin B12 , red cell folate , and cognitive impairment.
OBJECTIVE : To investigate the beneficial effect of the consumption of soft plain cheese on bone resorption markers in institutionalized elderly women.
OBJECTIVE : to investigate the change in non-participation between the Medical Research Council Cognitive Function and Ageing Study ( CFAS ) I and II.
OBJECTIVE : To investigate the changes in sound localization ability in the horizontal plane after canaloplasty in unilateral congenital aural atresia ( CAA ) patients.
OBJECTIVE : To investigate the characteristics of menopause of Chinese women with the age of 40-60 years concerning gynecologic clinics in China.
OBJECTIVE : To investigate the characters of corneal astigmatism in cataract surgery candidates.
OBJECTIVE : To investigate the clinical outcomes of one stage debridement and closed-suction drainage for treatment of infection after lumbar instrumentation.
OBJECTIVE : To investigate the complex relationship between leptin levels and cognitive decline in elderly Italians.
OBJECTIVE : To investigate the correlates of body mass index ( BMI ) among a national sample of older adults in the United States.
OBJECTIVE : To investigate the correlation between patient-dependent variables and dimensional variations of the maxillary sinus.
OBJECTIVE : To investigate the current status and distribution features of cognitive function among the elderly population of China.
OBJECTIVE : To investigate the durability of self-etch adhesives bonded to dentin in vitro.
OBJECTIVE : To investigate the effectiveness of recent social therapeutic interventions to reduce loneliness in older people.
OBJECTIVE : To investigate the effect of ADAMTS-13 in experimental SAH.
OBJECTIVE : To investigate the effect of botulinum toxin type A on tear film stability and tear production after treatment of lateral canthal rhytids.
OBJECTIVE : To investigate the effect of chronic ultraviolet ( UV ) exposure on skin barrier function and photoaging process.
OBJECTIVE : To investigate the effect of postoperative delirium on longitudinal brain microstructural changes , as measured by diffusion tensor imaging.
Objective : To investigate the effect of topical fluorouracil , @percent@ , cream on photoaging using validated photonumeric scales.
OBJECTIVE : to investigate the effects of 6-inch SHU for @number@ weeks in community-living patients with chronic OH.
OBJECTIVE : To investigate the effects of a 3-wk progesterone administration on sleep architecture and multiple hormonal profiles.
OBJECTIVE : To investigate the effects of AD-related gray matter neurodegeneration and high β-amyloid on white matter microstructure in older adults without dementia.
OBJECTIVE : To investigate the effects of mesterolone on prostate in patients treated for aging male syndrome.
OBJECTIVE : To investigate the effects of migraine and related pharmacotherapy on cognitive performance and cognitive change over time in a longitudinal population-based study.
OBJECTIVE : To investigate the effects of vascular risk factors and APOE status on white matter microstructure , and subsequent cognitive decline among older people.
OBJECTIVE : To investigate the efficacy and tolerability of Belotero.
OBJECTIVE : To investigate the efficacy of gastroscopic treatment in the treatment of membranous duodenal stenosis.
OBJECTIVE : To investigate the efficacy , patient satisfaction , and skin physiology after incobotulinumtoxinA treatment of the upper face.
OBJECTIVE : To investigate the efficacy , safety , and subject satisfaction of incobotulinumtoxinA for platysmal band treatment.
OBJECTIVE : To investigate the epidemiology of late-onset hypogonadism ( LOH ) in old and middle-aged males in the rural area of Southern China.
OBJECTIVE : To investigate the expression and significance of the MMP-7 , c-Jun and c-Fos in rat photoaging skin.
OBJECTIVE : To investigate the frequency and type of criminal behavior among patients with a diagnosed dementing disorder.
OBJECTIVE : To investigate the hypothesis that angiogenesis may be a critical link between hypertrophy and a series of stimulating events , including mechanical stress.
OBJECTIVE : To investigate the impact of 1-week ventilator circuit change on ventilator-associated pneumonia and its cost-effectiveness compared with a 2-day change.
OBJECTIVE : To investigate the impact of a train-the-trainer program on the nutritional status of older people in residential care.
OBJECTIVE : To investigate the impact of hearing aid ( HA ) and cochlear implant ( CI ) use on loneliness in adults.
OBJECTIVE : To investigate the impact of sex on cognition among cognitively normal older people without amyloid pathology.
OBJECTIVE To investigate the incidence , degree , and pattern of rib cartilage calcification in Asian patients.
OBJECTIVE : To investigate the influence of social network characteristics on subjective well-being over @number@ years in a population sample of older adults.
OBJECTIVE : To investigate the in vitro anti-aging potential of young and old leaves of Ma Kiang.
OBJECTIVE : To investigate the macular retinal sensitivity and fixation stability rates in normal subjects of middle and old age by using the MP-1 microperimetry.
OBJECTIVE : To investigate the normal hair characteristics of South Koreans using a phototrichogram.
OBJECTIVE : To investigate the prevalence and incidence of geriatric conditions in middle-aged and older-aged adults with diabetes.
OBJECTIVE : To investigate the prevalence of dry eye in populations equal or over @number@ years old in Jiangning District , Shanghai , China.
OBJECTIVE : To investigate the prevalence of hip osteoarthritis ( OA ) in a community-based elderly Korean population and to identify its risk factors.
OBJECTIVE : To investigate the prevalence of osteoarthritis in inhabitants aged @number@ years old and above from urban and rural areas in Heilongjiang province.
OBJECTIVE : To investigate the prevalence of rhinitis in elderly adults and its relations to asthma and other comorbidities.
OBJECTIVE : to investigate the reasons why older people in the community adjust their activity levels when living with chronic pain.
OBJECTIVE : To investigate the relation between lumbar disc degeneration ( LDD ) and all type of osteoporotic ( OP ) fractures including vertebral.
OBJECTIVE : To investigate the relationship between apathy and perceived quality of life in groups both with and without depressive symptoms or cognitive impairment.
OBJECTIVE : To investigate the relationship between cervical spine ( C-spine ) and rotator cuff ( RTC ) pathology.
OBJECTIVE : To investigate the relationship between clinical markers of ovarian reserve and the true ovarian reserve as determined by the ovarian primordial follicle number.
OBJECTIVE : To investigate the relationship between morphometric age and posttransplant survival.
OBJECTIVE : To investigate the relationship between mortality and BMI in older people , taking into account other established mortality risk factors.
OBJECTIVE To investigate the relationship between serum carboxymethyllysine ( CML ) , a major circulating advanced glycation end product , and AMD in older adults.
OBJECTIVE : To investigate the risk factors and behavior features related to chronic diseases among adults in Shanghai.
OBJECTIVE : To investigate the role of cyclophilin A ( CypA ) and CD147 in the process of skin aging.
Objective : To investigate the role of L5 in the mechanism of adipose tissue inflammation associated with MetS.
OBJECTIVE : To investigate the role of menopause , body mass index ( BMI ) and aging on body fat distribution in women.
OBJECTIVE : To investigate the role of WMHs as a predictor of decline in physical function in cognitively intact older people.
OBJECTIVE : To investigate the shoulder proprioception in patients with SIS.
OBJECTIVE : To investigate the situation of overactive bladder ( OAB ) in a community-based male population.
OBJECTIVE : To investigate the suitability of BMI as a surrogate of percent body fat ( %BF ) in pediatric longitudinal investigations.
OBJECTIVE : To investigate the surgical options for the malignant pancreatic neuroendocrine tumor ( PNETs ) .
OBJECTIVE : To investigate the temporal ordering of cognitive and functional declines separately in older adults with or without Alzheimer's disease ( AD ) .
OBJECTIVE : To investigate trends in the incidence of lens extraction over the past @number@ years.
OBJECTIVE : To investigate VOR gain and compensatory saccades with vHIT and compare them to the DVA of patients with unilateral peripheral vestibulopathy.
OBJECTIVE : To investigate whether advanced paternal age is related to an increased risk of schizophrenia in Chinese Han population.
OBJECTIVE : To investigate whether athletic participation allows master athletes to preserve their good bone health into old age.
OBJECTIVE : To investigate whether automatic auditory post-processing is deficient in patients with Alzheimer's disease and is related to sensory gating.
OBJECTIVE : To investigate whether having an offspring protects against or increases the risk of depressive disorders.
OBJECTIVE : to investigate whether high morale is associated with increased survival among very old people.
OBJECTIVE : To investigate whether laboratory strategies can improve in vitro fertilization ( IVF ) outcome in poor responder patients.
OBJECTIVE : To investigate whether lifestyle and lipid factors predict new CMBs in relation to their anatomic location.
OBJECTIVE : To investigate whether otolith function ( saccular and utricular ) is associated with walking performance.
OBJECTIVE : To investigate whether patients with behavioral variant frontotemporal dementia ( bvFTD ) have dysregulation in satiety-related hormonal signaling using a laboratory-based case-control study.
OBJECTIVE : To investigate whether previously noted associations between health literacy and functional health status might be explained by cognitive function.
OBJECTIVE : To know the prevalence and etiology of oral and maxillofacial trauma in elders.
Objective : To longitudinally document patterns of change in the facial skeleton and determine a consistent methodology for measuring these changes.
OBJECTIVE : To measure protein digestibility and the response to pancreatic enzyme intake in CF by using a new stable isotope methodology.
Objective : To measure the association of face-lift surgery with observer-graded perceived age , attractiveness , success , and overall health.
OBJECTIVE : to measure the effect of TREAT on LOS and the rate of same-day discharges ( an inverse measure of admission rate ) .
Objective : to measure the health and functioning of people moving into care homes and how they have changed between @number@ and @number@
OBJECTIVE : To meta-analytically examine the trends and correlates of antipsychotic use in youth with mood disorders.
OBJECTIVE : To monitor time variability of early embryo cleavage by continual monitoring system ( time-lapse ) .
OBJECTIVE : To observe the association of osteoporotic fracture with habits of smoking , alcohol consumption , tea consumption and exercise among very old people.
OBJECTIVE : To present a classification of the deviated nose with unilateral cleft lip and the associated surgical correction.
OBJECTIVE : To present an overview of the prevalence of multimorbidity and comorbidity of chronic diseases in the Dutch population.
OBJECTIVE : To present a rare case of suspected progeria in Nigeria.
OBJECTIVE : To present gait pattern of healthy older specially selected to be \ "healthy walkers \ ".
OBJECTIVE : To present results of in vitro studies of recombinant otoconial proteins for the understanding of current concepts of biomolecular mechanisms controlling otoconial mineralization.
OBJECTIVE : To present the epidemiology of chronic gout and to discuss its disease burden.
OBJECTIVE : To present the first wide-scale survey to assess perceptions of testing the aging neurosurgeon.
OBJECTIVE : To produce age-related normograms for antral follicle count in an infertile population without polycystic ovaries.
OBJECTIVE : To produce age-related normograms for serum antimüllerian hormone ( AMH ) level in infertile women without polycystic ovaries ( non-PCO ) .
OBJECTIVE : To project the population impact and cost-effectiveness of statin therapy in adults aged @number@ years or older.
OBJECTIVE : To promote healthy aging in older nursing home ( NH ) residents , it is important to identify factors that impact functional performance.
OBJECTIVE : To provide an evaluative overview of the life and contributions of Raja Parasuraman.
OBJECTIVE : To provide an introduction to this special focus issue of Spine journal that deals with CSM.
OBJECTIVE : To provide an overview of non-pharmacological interventions for behavioural and psychological symptoms in dementia ( BPSD ) .
OBJECTIVE : To provide an update of the associations between sedentary behaviour and dietary intake across the lifespan.
OBJECTIVE : To provide clinical experience with its cosmetic use , solely and in conjunction with other nonpermanent fillers , in a private practice setting.
OBJECTIVE : To provide primary care physicians with an approach to driving safety concerns when older persons present with memory difficulties.
OBJECTIVE : To provide rationale for testosterone replacement therapy ( TRT ) in older men with low testosterone levels and symptoms consistent with testosterone deficiency.
OBJECTIVE : To provide readers with a history of the cosmetic use of BoNTA and future directions.
OBJECTIVE : To provide RT reference data and to characterize the age-related changes in RT measured by the Nintendo Wii Balance Board.
OBJECTIVE : To quantify racial differences in brain structural characteristics in white and black octogenarians , and to examine whether these characteristics contribute to cognition.
OBJECTIVE : To quantify the number of cases and prevalence of human immunodeficiency virus ( HIV ) infection among older adults in sub-Saharan Africa.
OBJECTIVE : To quantify the risk of dementia among adults with recent TBI compared with adults with NTT.
OBJECTIVE : To quantify the socioeconomic burden of frontotemporal degeneration ( FTD ) compared to previously published data for Alzheimer disease ( AD ) .
OBJECTIVE : To quantitatively evaluate the performance of the ADC program over the past @number@ years.
OBJECTIVE : To recognize relationship of protein related neurodegeneration abnormal aggregation in the aged brains with their cognitive and motor functions.
OBJECTIVE : To reduce IM prescriptions based on explicit Beers criteria using a nurse-led intervention in a nursing-home ( NH ) setting.
OBJECTIVE : To reexamine the association between the neuronal sortilin-related receptor gene ( SORL1 ) and Alzheimer disease ( AD ) .
OBJECTIVE : To report another four patients with this phenomenon.
OBJECTIVE : To report the frequency of hearing impairment among vision rehabilitation clients , and to identify patterns of hearing service and aid use.
OBJECTIVE : To report the long-term safety and efficacy of abobotulinumtoxinA in patients with moderate to severe glabellar lines.
OBJECTIVE : To report the results of a unique art project organized to promote rapport between medical students and healthy older adults.
OBJECTIVE : To reveal the enhancement of the maceration-induced ultrastructural alteration and barrier function of the epidermis by aging.
OBJECTIVE : To reveal the morphological features of the aorta in its dissection in persons of different age groups.
OBJECTIVE : To review how disability can develop in older adults with critical illness and to explore ways to reduce long-term disability following critical illness.
OBJECTIVE : To review surgical neck rejuvenation therapies available currently to find the best option for male patients.
OBJECTIVE : To review the discovery of chromothripsis and analyze its impact on human reproduction.
OBJECTIVE : To review the effects of aging and menopause in immune system.
OBJECTIVE : To review the indications for chemical peels with an emphasis on performing this procedure in male patients.
OBJECTIVE : To review the influences of vitamin D on the aging process other than those related to bone and calcium.
OBJECTIVE : To review the role of microRNA ( miRNA ) in skin development and wound healing.
Objective : To search for rare variants contributing to the risk for EOAD.
OBJECTIVE : To seek an explanation of nursing practice with hospitalised older adults.
OBJECTIVE : To shed light on the association between socioeconomic parameters , physical characteristics , and DLSS.
OBJECTIVE : To spread and update information on the clinical usefulness of elderly asmathic patients.
OBJECTIVE : To study differences in consumption of foods and intake of nutrients attributable to denture status.
OBJECTIVE : To study functional outcomes and mortality after osteosynthesis of hip fractures in very old patients in our clinic.
OBJECTIVE : To study gait characteristics in different frailty status groups for identifying the most useful parameters and assessment protocols for frailty diagnosis.
OBJECTIVE : To study physician perceptions about generic medications.
OBJECTIVE : To study risk factors of cardiovascular disease ( CVD ) and status of bone mineral density ( BMD ) in women with hypoestrogenism.
OBJECTIVE : To study the age and sex influence on bone and blood lead concentrations in a cohort of the general population living in Toronto.
OBJECTIVE : To study the alterations in HbA ( 1c ) with advancing age in subjects with normal glucose tolerance.
OBJECTIVE : To study the association between the availability of healthy foods and BMI by neighbourhood race and socio-economic status ( SES ) .
OBJECTIVE : To study the association of genetic variants with AF at GWAS top loci.
OBJECTIVE : To study the associations of pedestrian injuries with age , income and educational level in Shanghai and to analyze the relative disease burden.
OBJECTIVE : To study the border between the lateral-temporal and the middle cheek fat compartments of the face.
OBJECTIVE : To study the clinical application value of middle segment pancreatectomy in the treatment of benign tumors of the amphi-neck of the pancreas.
OBJECTIVE : To study the effectiveness of simply-performed balancing exercises in fall prevention.
OBJECTIVE : To study the effect of age on the association between body fat percentage and maximal walking speed in older people.
OBJECTIVE : To study the effect of three energy drinks on the color stability of nanofilled composite resins after different periods of aging time.
OBJECTIVE : To study the frequency of frailty phenotype and its association with mental health and survival in older Chileans.
OBJECTIVE : To study the pattern and frequency of glabellar contraction patterns in the Chinese population.
OBJECTIVE : To study the prevalence of food intolerance among attendants in a general hospital and to learn its related determinants in Beijing , China.
OBJECTIVE : To study the profile of IGF2R expression and histone modifications in replicative cell senescence.
OBJECTIVE : To study the profile of P66SHc expression and histone modifications in replicatively senescenct cells and oxidative-stress inducing premature senescenct cells.
OBJECTIVE : To study the relation between rainfall and outpatient visits for joint or back pain in a large patient population.
OBJECTIVE : To study the relationship between the decline of age-related renal function and central arterial pressure ( CAP ) in Uygur healthy population.
OBJECTIVE : To summarise the clinical presentation , aetiology , diagnosis , treatment , and neuropsychiatric complications of epilepsy in old age.
OBJECTIVE : To summarize and critically appraise the evidence from SRs of the primary studies on nonpharmacologic interventions to treat PUs in older patients.
OBJECTIVE : To summarize the current knowledge about the association between paternal age and assisted reproductive technology ( ART ) outcomes.
OBJECTIVE : To summarize the experience and characteristics of the modified laparoscopic splenectomy for massive splenomegaly in the treatment of children with hematologic disease.
OBJECTIVE : to supplement this review by analysing older people's participation in the trials and engagement with the interventions.
OBJECTIVE : To synthesize the evidence on factors associated with the maintenance of work ability during the aging process.
OBJECTIVE : To systematically review evidence on aging of the body systems after spinal cord injury ( SCI ) .
OBJECTIVE : Total testosterone concentrations are influenced by sex hormone-binding globulin ( SHBG ) concentrations , which are decreased by obesity and increased with ageing.
OBJECTIVE : To test a model to explain the relationships between health literacy , heart failure knowledge , self-efficacy , and self-care.
OBJECTIVE : To test a nonpharmacologic intervention realigning environmental demands with patient capabilities.
OBJECTIVE : To test if dimebon affected alpha-synuclein-induced pathology using a transgenic animal model.
OBJECTIVE : to test self-reported and objective measures of physical functioning in predicting subsequent disability in cooking , shopping and housework.
OBJECTIVE : to test the effect of a 16-week multimodal exercise program on neurocognitive and physical functioning and brain-derived neurotrophic factor ( BDNF ) .
OBJECTIVE : To test the effects of oral supplementation with nutrients on cognitive function.
Objective : To test the hypothesis that greater cortisol responsivity to acute stressors predicts more rapid telomere attrition.
OBJECTIVE : To test the hypothesis that late-life depression is associated with dementia-related pathology.
OBJECTIVE : To test the hypothesis that mild cognitive impairment ( MCI ) is associated with poorer financial and healthcare decision-making.
OBJECTIVE : To test the hypothesis that negative social interaction is associated with increased risk of mild cognitive impairment and rate of cognitive decline.
OBJECTIVE : To test the hypothesis that neurodegeneration and neuronal density in brainstem aminergic nuclei are related to late-life depressive symptoms.
OBJECTIVE : To test the hypothesis that older adults demonstrate impaired muscle blood flow and lower intravascular ATP during conditions of erythrocyte deoxygenation.
Objective : To test the hypothesis that testosterone treatment of older men with low testosterone slows progression of noncalcified coronary artery plaque volume.
OBJECTIVE : To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability.
OBJECTIVE : To test the hypothesis that transactive response DNA-binding protein @number@ ( TDP-43 ) is related to late-life cognitive decline.
Objective : To test the hypothesis that urinary incontinence ( UI ) is associated with incident parkinsonism in older adults.
OBJECTIVE : To test the hypothesis that women with unexplained infertility demonstrate evidence of diminished ovarian reserve when compared with a population of community controls.
OBJECTIVE : To test the mechanical properties of three different restorative materials for implant abutments supporting all-ceramic single crowns.
OBJECTIVE : To test the relationship between gonadal status and objective measures and determinants of physical performance in older men and their determinants.
OBJECTIVE : To test whether limitations in mobility and large-muscle functioning mediate self-reported vision status to increase fall risk among respondents age @number@ and above.
OBJECTIVE : To test whether the cochlear position and orientation , which are important in cochlea implant surgery , change during postnatal development.
OBJECTIVE : To test whether the normal aging itself may change the cortical plasticity in human.
OBJECTIVE : To translate the Tilburg Frailty Indicator ( TFI ) into Chinese and assess its reliability and validity.
OBJECTIVE : To understand and analyze the morphological characteristics of hyoid bone and its gender difference in order to find out its forensic significance.
Objective : To understand the influence on metabolic changes of diet and SNS during @number@ hours of overfeeding.
OBJECTIVE : To understand the relationship between eye contact and patient-centered communication ( PC ) in physician-elder patient interactions.
OBJECTIVE : To understand the relationships between brain structures and function ( behavior and cognition ) in healthy aging.
Objective : To validate an objective evaluation method that can be used to define the perception of facial age in scientific studies.
OBJECTIVE : to validate the identification of seniors at risk-hospitalised patients ( ISAR-HP ) , in older patients undergoing cardiac surgery.
OBJECTIVE : Traumatic brain injury ( TBI ) is a multifactorial pathology with great interindividual variability in response to injury and outcome.
OBJECTIVE : Treating insomnia includes challenging unrealistic beliefs that may contribute to anxieties and wakefulness.
OBJECTIVE : Type @number@ diabetes mellitus ( DM ) accelerates brain aging and cognitive decline.
OBJECTIVE : Type @number@ narcolepsy / hypocretin deficiency is characterized by excessive daytime sleepiness , sleep fragmentation , and cataplexy.
OBJECTIVE : Understanding of the underlying mechanisms of Fear of Falling ( FoF ) could help to expand potential treatments.
OBJECTIVE : Understanding the mechanisms linking sleep impairment to morbidity and mortality is important for future prevention , but these mechanisms are far from elucidated.
OBJECTIVE : Vascular lesions seen through brain imaging as hyperintensities are associated with both depression and functional impairment in older adults.
OBJECTIVE : Vascular risk is associated with impairments in age-sensitive cognitive functions.
OBJECTIVE : Vegetarians are more vascular-healthy but those with subnormal vitamin B-12 status have impaired arterial endothelial function and increased intima-media thickness.
OBJECTIVE : Verification of self-medication prevalence and associated factors in the elderly , as well as identification of the main categories of non-prescription drugs utilized.
OBJECTIVE : Very few findings regarding the perceived needs of elderly cancer patients have been reported.
OBJECTIVE : Visceral white adipose tissue ( WAT ) expansion and macrophage accumulation are associated with metabolic dysfunction.
OBJECTIVE : Vitamin B12 ( B12 ) deficiency is most prevalent among older adults.
OBJECTIVE : Voice problems in the geriatric population are increasing worldwide.
OBJECTIVE : Wandering in persons with dementia is perceived as significant due to its prevalence and negative outcomes.
OBJECTIVE : We aimed at comparing markers of bone metabolism during unloading in young and older men , and to assess countermeasure effectiveness.
OBJECTIVE : We aimed to assess the effectiveness of omega-3 fatty acids versus placebo , in improving the symptoms and signs of MGD.
OBJECTIVE : We aimed to describe the prevalence and associated characteristics in relation to a food-addiction scale in middle-aged and older women.
Objective : We aimed to determine the consequences of a serum klotho ( seKL ) defect on cardiovascular morbidity and mortality during chronic dialysis.
OBJECTIVE : We aimed to develop and evaluate a simple symptom screen using data obtained from a representative sample of community-dwelling older adults.
OBJECTIVE : We aimed to estimate distribution , pharmacological treatment , and control of main cardiometabolic risk factors among older people.
OBJECTIVE : We aimed to evaluate risk of unsafe on-road driving performance among older adults with MCI.
OBJECTIVE : We aimed to evaluate the quality and determinants of vitamin K antagonists ( VKA ) control among very elderly patients in geriatric settings.
OBJECTIVE : We aimed to examine the current developments and challenges confronted by old age security in rural China.
OBJECTIVE : We aimed to examine the general health and intestinal physiology of young and old non-human primates with comparable life histories and dietary environments.
OBJECTIVE : We aimed to examine the relationship between healthcare discrimination and new or worsened disability.
OBJECTIVE : We aimed to explore factors associated with clinical evaluations for cognitive impairment among older residents of the United States.
OBJECTIVE : We aimed to explore the relation between systemic oxidative stress biomarkers excreted in urine and urinary osmolality ( Uosm ) .
OBJECTIVE : We aimed to investigate the appropriateness of the Mini Nutritional Assessment ( MNA ) in predicting functional ability in older adults.
OBJECTIVE : We aimed to investigate the association between air pollution and adult onset asthma.
OBJECTIVE : We aimed to provide an evidence- and consensus-based revision of the clinical diagnostic criteria for PSP.
OBJECTIVE : We aimed to reveal associations between CAA-related brain microbleeds and cerebrospinal fluid ( CSF ) markers in AD patients.
OBJECTIVE : We analyzed associations between a battery of gait characteristics and frailty status across four different frailty instruments in old patients.
OBJECTIVE : We assessed associations of T , DHT , and E2 with all-cause and ischemic heart disease ( IHD ) mortality in older men.
OBJECTIVE : We assessed the association between black carbon ( BC ) , a marker of traffic-related air pollution , and cognition in older men.
Objective : We attempted to characterize the pancreatic pathology in eT2DM and sought its clinical implications.
OBJECTIVE : We characterized long-term body-composition changes associated with the DM trial and potential modifiers of these associations.
OBJECTIVE : We compared the effects of acute and chronic soccer training plus calorie-restricted diet on protein catabolism and cardiovascular risk markers in T2D.
OBJECTIVE : We conducted a comprehensive meta-analysis on associations between genetic polymorphisms of any gene and VaD to investigate the genetics of VaD.
OBJECTIVE : We conducted a meta-analysis to evaluate the relationship between vitamin E and age-related cataract ( ARC ) .
OBJECTIVE : We conducted a systematic review to determine the effectiveness of interventions to deprescribe inappropriate PPIs in older adults.
OBJECTIVE : We described a case of cerebral venous sinus thrombosis in a patient taking multiple supplements as part of a naturopathic anti-aging regimen.
OBJECTIVE : We detail a new approach to the creation of normative data for neuropsychological tests.
Objective : We evaluated provider- and site-level determinants of receipt of testosterone and of guideline-concordant testosterone prescribing.
OBJECTIVE : We evaluated the capacity of PCIs to impair the IgE-binding capacity of airborne HDM allergens under a simulated indoor environmental condition.
OBJECTIVE : We evaluated the clinical effects and objectively quantified the histologic changes of the nonablative RF device in the treatment of photoaging.
OBJECTIVE : We evaluated whether dietary omega-3 fatty acids and fish consumption were associated with increased risk of T2D.
OBJECTIVE : We examined ages at which PPGLs were diagnosed according to different catecholamine phenotypes and locations of tumors.
OBJECTIVE : We examined disparities in hazardous employment characteristics and working conditions among Chinese and white workers in Toronto , Canada.
OBJECTIVE : We examined gender differences in the prevalence of disability and Disability-free Life Expectancy ( DFLE ) for Bangladeshi older adults.
OBJECTIVE : We examined how family support influenced the use of health services among older Chinese adults.
OBJECTIVE : We examined psychosocial and informational services used by long-term survivors of breast , colon and prostate cancer in immigrants versus non-immigrants.
OBJECTIVE : We examined the association between falls and medication use in the Alzheimer's Disease Neuroimaging Initiative ( ADNI ) .
OBJECTIVE : We examined the association between HbA1c level and self-reported severe hypoglycemia in patients with type @number@ diabetes.
OBJECTIVE : We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.
OBJECTIVE : We examined the associations of handgrip strength , upper arm circumference , and waist circumference with dementia among Singapore older adults.
OBJECTIVE : We examined the diagnostic and predictive value of high-sensitivity cardiac troponin T ( cTnThs ) in patients with syncope.
OBJECTIVE : We examined the effect of @number@ days of bed rest on fatty acid kinetics and hepatic and peripheral insulin resistance in aging.
OBJECTIVE : We examined the effect of poly ( I : C ) on MMP-1 , @number@ and @number@ expressions in human skin fibroblasts.
OBJECTIVE : We examined the relation between perceived stress and the rate of decline in different cognitive domains.
OBJECTIVE : We examined the relation of flavonoid intake in midlife with the prevalence of healthy aging.
OBJECTIVE : We examined the relationship of sleep duration with obesity and sarcopenia in community-dwelling older adults.
OBJECTIVE : We examined the validity of a ' walking while talking ' ( WWT ) task for predicting falls.
OBJECTIVE : We examined whether a peroxisome proliferator-activated receptor γ ( PPAR-γ ) agonist , pioglitazone , suppresses coronary spasm.
OBJECTIVE : We further evaluated and characterized kynurenine-based indexes as possible markers of functional B-vitamin status in plasma.
OBJECTIVE : We hypothesised , that a GH blockade would decrease IGF-I and collagen synthesis in the connective tissue of skeletal muscle and tendon.
OBJECTIVE : We hypothesized that leukocyte telomere length ( LTL ) plays an important role in the pathophysiology of PCOS.
OBJECTIVE : We hypothesized that the age-related BDNF decline is abnormal and contributes to the reduced BDNF in schizophrenia.
OBJECTIVE : Weight changes may be an important indicator of an ongoing pathological process.
OBJECTIVE : We investigated suspected longitudinal interaction effects of apolipoprotein E ( APOE ) genotype and educational attainment on cognitive decline in normal aging.
OBJECTIVE : We investigated the alteration of lipid metabolism in the epidermis by photoaging and acute UV irradiation in human skin.
OBJECTIVE : We investigated the clinical characteristics of CIA , including permanent CIA in childhood.
OBJECTIVE : We investigated the effect of PB in older adults.
OBJECTIVE : We investigated the effects of B vitamins and omega-3 ( n-3 ) fatty acid supplementation on cognition in a high-risk population.
OBJECTIVE : We investigated the effects of six months vitamin E administration on cognition evaluated by event-related potentials in exercising older subjects.
OBJECTIVE : We investigated the function of periostin concerning collagen homeostasis during intrinsic and extrinsic skin aging.
OBJECTIVE : We investigated the neurophysiological mechanisms underpinning the generation of the mismatch negativity ( MMN ) in the ageing brain.
OBJECTIVE : We investigated the predictive validity of the LIBRA index for incident dementia in midlife , late life , and the oldest-old.
OBJECTIVE : We investigated the protective effects of apigenin and luteolin on immortalized human keratinocytes ( HaCaT ) against UVA damage.
OBJECTIVE : We investigated the protective effects of GlcNAc on immortalized human skin fibroblasts ( HS68 ) against UVB damage.
OBJECTIVE : we investigated the relationship between baseline hand-grip strength and the risk of depressive symptoms.
OBJECTIVE : We investigated the relationship between gait speed and cognitive decline over @number@ years in a community dwelling sample of elderly Africans.
OBJECTIVE : We investigated the role of metformin on glucose kinetics during moderate exercise.
OBJECTIVE : We investigated to evaluate the effect of acetyl hexapeptide-3 and tripeptide-10 citrulline and the possible synergism between these two peptides.
OBJECTIVE : We investigated whether Lp-X induces foam cell formation in human-derived macrophages.
OBJECTIVE : We investigated whether @number@ weeks of aerobic exercise could enhance functional connectivity of the PCC / precuneus in MCI and healthy elders.
OBJECTIVE : We investigated whether @number@ wk of daily flavanone-rich orange juice consumption was beneficial for cognitive function in healthy older adults.
OBJECTIVE : We investigate the associations of these overlapping psychosocial factors with incident MCI-dementia ( neurocognitive disorder ) in a population cohort.
OBJECTIVE : We previously reported that serum PCSK9 levels are higher in postmenopausal women than in premenopausal women in a Han Chinese population.
OBJECTIVE : We prospectively determined the association between diet quality and quality of life and activities of daily living.
OBJECTIVE : We prospectively examined the association between lead exposure and the development of electrocardiographic conduction abnormalities.
OBJECTIVE : We set out to describe the pattern of death due to cancer in our medical ward.
OBJECTIVE : We set out to provide such reference lipid data using a large contemporary population-based cohort study.
OBJECTIVE : We sought to characterize racial differences in disability among older stroke survivors.
OBJECTIVE : We sought to characterize whether there is a cross-sectional association between age and HDL-C in a contemporary community-based study of African Americans.
OBJECTIVE : We sought to compare the effectiveness of appearance-based video education with that of health-based video education in improving sunscreen use and knowledge.
OBJECTIVE : We sought to define the frequency of B-cell subsets associated with progressive B-cell maturation and IgE class-switching.
OBJECTIVE : We sought to determine whether a telomere phenotype is present in immune cells from patients with CHH and explore mechanisms underlying these observations.
OBJECTIVE : We sought to determine whether placentas from late-term pregnancies and unexplained stillbirth show oxidative damage and other biochemical signs of aging.
OBJECTIVE : We sought to develop and validate a risk index for prospective cognitive decline in older adults based on blood-derived markers.
OBJECTIVE : We sought to develop risk scores for the progression from cognitively normal ( CN ) to mild cognitive impairment ( MCI ) .
OBJECTIVE : We sought to evaluate efficacy and safety of microfocused ultrasound with visualization treatment of décolletage laxity and rhytides.
OBJECTIVE : We sought to examine the relation between plasma phospholipid n-3 FAs and incident diabetes.
OBJECTIVE : We sought to improve prescribing among older hospitalized patients by adding alerts to the CPOE system for potentially inappropriate medications.
OBJECTIVE : We sought to quantify the molecular changes that result from erbium : yttrium-aluminium-garnet ( Er : YAG ) laser microablative resurfacing.
OBJECTIVE : We sought to systemically review clinical evidence for the use of botanically derived agents and vitamins as photoprotective agents.
OBJECTIVE : We studied the ability of a topical serum containing epidermal growth factor ( EGF ) to minimize the appearance of under-eye bags.
OBJECTIVE : We studied the longitudinal relation between telomere length , the change in telomere length , and circulating amino acids.
OBJECTIVE : We tested an uncertainty self-management telephone intervention ( SMI ) with patients awaiting liver transplant and their caregivers.
OBJECTIVE : We tested the hypothesis that chocolate consumption is inversely associated with incident DM in the Physicians ' Health Study ( PHS ) .
OBJECTIVE : We tested the hypothesis that dairy food consumption is associated with cerebral glutathione concentrations in older adults.
OBJECTIVE : We tested whether attending to the present and discounting the future may moderate the influence of income on food insecurity.
OBJECTIVE : We used regression analysis to investigate associations of EZP with age , sex , body size , and zinc nutrition variables.
OBJECTIVE : We used the Human-Centered Design approach to propose a prototype that more effectively engages older adults in their health care decision-making.
OBJECTIVE : While the benefits of hearing aids among older adults with presbycusis have been well documented , there is limited research on hearing-aid usage.
OBJECTIVE : While the education gradient in prevention of chronic conditions is well documented , contributing factors remain underexplored.
OBJECTIVE : White matter diffusivity measures of the fornix change with aging , which likely relates to changes in memory and cognition in older adults.
OBJECTIVE : White matter hyperintensities ( WMH ) , visualized on T2-weighted MRI , are thought to reflect small-vessel vascular disease.
OBJECTIVE : White matter lesions ( WMLs ) are associated with depressive symptoms in older adults.
OBJECTIVE : With aging , kidney function declines , as evidenced by reduced glomerular filtration rate.
OBJECTIVE : With aging , skin is likely to become less hydrated , thereby increasing its resistance to electrical current.
OBJECTIVE : With an aging society , elderly patients increasingly require long-term placement of urethral balloon catheters.
OBJECTIVE : With increasing life expectancy , there is a focus on \ "healthy ageing \ ".
OBJECTIVE : Within-person variability in cognitive performance is related to neurological integrity , but the association with functional abilities is less clear.
OBJECTIVE : Worry is a hallmark feature of generalized anxiety disorder ( GAD ) .
Object locations were initially encoded incidentally , and appeared in a single space against a @number@ × @number@ grid.
Objects are not aversive or food-based , which are hormone-sensitive factors.
Objects were either animals or pieces of furniture , embedded in either congruent or incongruent contexts.
OBJETIVO : Analisar o uso de medicamentos anti-hipertensivos em idosos e a associação com características socioeconômicas e comportamentais.
OBJETIVO : Descrever a metodologia utilizada no processo de estabelecimento de prioridades em saúde para intervenção comunitária , numa comunidade idosa.
OBJETIVO : Descrever a prevalência e fatores sociodemográficos associados à ajuda informal e remunerada a idosos com limitações funcionais.
Observational and interventional evidence suggests that physical activity may reduce the risk of age-related disability , as assessed by physical performance measures.
Observational cohort study of older adults ( 70-79 years ) living in Pittsburgh , PA , USA or Memphis , TN , USA.
Observational data had also suggested a significantly decreased risk for dementia in women who had been treated with estrogens for menopausal symptoms in midlife.
Observational results raise the possibility of long-term cognitive benefit , but bias is a concern in interpreting these findings.
Observational scales that provide descriptors that correspond to how people actually display facial expressions of pain perform better at differentiating intensities of pain.
Observational studies and randomized controlled trials ( RCTs ) were considered.
Observational studies demonstrate that protective crack deflection in the elderly is reduced.
Observational studies have found associations of low testosterone concentrations in older men with adverse symptoms ; however , these associations do not prove causality.
Observational studies have investigated the association between antipsychotics and stroke but results vary , which may be due to lack of control for unmeasured confounding.
Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex.
Observational studies have suggested that colonoscopies strongly reduce the risk of CRC , but there is little specific evidence on the effects of screening colonoscopies.
Observational studies of testosterone supplementation have reported contrasting results.
Observational studies support a beneficial association between intake / blood levels of DHA / EPA and memory function in older adults.
Observational study data mostly reflects long-term use in women who survive the early increase , while trials mainly reflect short-term use.
Observation occurred at @number@ clinical sites of medical retinal practices from academic institutions and community medical centers.
Observation of a patient's respiration signal can provide a clinician with the required information necessary to analyse a subject's wellbeing.
Observation periods were divided into four 12-month intervals.
Observations are yet to be made in male subjects during replacement therapy.
Observations from new mouse models and humans are discussed here to support the vascular aging theory.
Observations from these experiments revealed that the regulation of stem cells by Runx family genes turned out to be far more complex than previously thought.
Observations in a range of species show that performance between sequential reproductive events can decline , remain consistent or increase.
Observations of @number@ home visits , followed by @number@ semi-structured interviews , were conducted with occupational therapists.
Observations over the past decade using longitudinal data reveal a gender-specific shift in adrenal steroid production.
OBSERVATIONS : PGD and fertilization cycles resulted in detection of @number@ F198S mutation-free embryos.
OBSERVATIONS : Two patients received abobotulinumtoxinA ; one received the current formulation of onabotulinumtoxinA and one both abobotulinumtoxinA and onabotulinumtoxinA.
Observed and self-reported ability to walk @number@ m at baseline and at @number@ yrs were primary outcomes.
Observed changes in cellularity were significantly associated with age , but not NP , in HIV + individuals.
Observed conformational features have been compared to that of Substance P potent NK1 agonist.
Observed deaths were @number@ ( @percent@ ) .
Observed DNA methylation changes were also further analyzed to examine their relationship with previous hospitalized myocardial infarction.
Observed frequencies were similar in men and women , with a slight male predominance.
Observed morphological changes suggest that tissue damage upon loading may not be entirely preventable.
Observed rates ranged from @percent@ to @percent@ across states.
Observed survival ( OS ) was calculated for each cancer type.
Observed trends revealed differences in spatial behaviors in the pre- and post- environments attributable to the physical environment.
Observed variations in transcript abundance are therefore likely to be biologically meaningful , especially if multiple genes within the same pathway are simultaneously affected.
Observer mice froze to subject footshocks only when they had a similar shock experience @number@ hours earlier.
Observers assessed the age with ranges of @number@ and @number@ years , indicating also the body part they mainly observed for each case.
Observers estimated age and rated the attractiveness , perceived success , and perceived overall health for each patient image.
Observers responded to whether audiovisual pairs were perceived as synchronous or asynchronous via a button press.
Observers were schoolmates of 7-17 years and adults.
Observing individual differences in treatment effects is therefore an essential step in the development of personalized medicine.
Obsessive-compulsive disorder ( OCD ) is a polygenic neuropsychiatric disorder characterized by repetitive thoughts and behaviors that cause distress.
Obstacles to making changes in diets included participants ' false ideas about nutrition , especially with regard to weight gain.
Obstructive pattern was defined as FEV ( @number@ ) / FVC < @percent@.
Obstructive sleep apnea hypopnea syndrome ( SAHS ) is a complex disease of the upper respiratory airways.
Obstructive sleep apnea ( OSA ) is accompanied by neurocognitive impairment , likely mediated by injury to various brain regions.
Obstructive sleep apnea ( OSA ) is a growing public health hazard fueled by the obesity epidemic and an aging population.
Obstructive sleep apnea ( OSA ) is associated with cardiometabolic diseases.
Obstructive sleep apnea ( OSA ) is one of the most common sleep disorders.
Obstructive Sleep Apnea Syndrome ( OSAS ) is characterized by repeated episodes of upper airway obstruction during sleep that result in intermittent hypoxemia and arousal.
Obstructive Sleep Apnea Syndrome ( OSAS ) is mainly associated with executive dysfunction.
Obtained results can contribute to understanding of changes , which proceed in metabolism of xenobiotics during diabetes mellitus and ageing.
Obtained results provide evidence for the absence of size invariance when perceiving the Kanizsa illusion in our experimental conditions.
Obtaining informed consent is problematic when potential participants lack the capacity to provide it.
Obtaining reliable data in the nursing consultation , resolution and family support were considered as challenges.
OBT-A was administered according to the PREEMPT paradigm in most centers ( @percent@ ) .
Obviously , all of these changes are more pronounced in AD and proceed faster providing the basis for an AD diagnosis.
Obviously , along with adaptation to hypoxia , Spalax has evolved efficient anti-cancer mechanisms yet to be elucidated.
Occasional episodes of symptomatic infection may be accompanied by localizing genitourinary findings.
Occasionally , events occur that enable permanent change.
Occasionally , however , S pneumoniae can cause severe disease such as pneumonia.
Occasionally , HS may be the only neuropathological change detected in older individuals with dementia and is known as pure HS.
Occasionally reported higher sensitivities for specific antibodies are yet to be replicated in independent studies.
Occasionally , treatment of indirect CCFs with conventional endovascular approach through large veins or the inferior petrosal sinus may not be possible.
Occasional offspring / caregivers with previous substitute decision maker experience reported distress related to their decisions.
Occipital alpha , which has been linked to internally oriented brain states , saturates faster in younger adults.
Occipital FDG-PET hypometabolism accurately classified coincident DLB ( @percent@ sensitivity and @percent@ specificity ) .
Occipital GMv loss accounted for underrecruitment at encoding.
Occipital sites had alpha clusters of higher average frequency , higher power , and greater presence across the scalp.
Occupational exposure was self assessed.
Occupational factors played a substantial role in explaining social disparities in mortality , especially for premature mortality and men.
Occupational prestige was not independently associated with adherence any the guidelines.
Occupational therapists should encourage older people to seek sensory input and provide them with rich sensory environments for enhancing meaningful engagement in real life.
Occurrence of more than one ARD in an individual , expresses the need of discovery of such target proteins , which can affect multiple ARDs.
Occurrence of PAD as a complication was assessed using ankle brachial pressure index ( ABI ) and toe brachial pressure index ( TBI ) tests.
Occurrences of mutations in this gene vary across ALS populations.
OC may alter parameters related to ovarian reserve assessment but the extent of the reduction is uncertain.
Ocriplasmin , by degrading laminin and fibronectin at the vitreoretinal interface , may allow induction of PVD in a non-invasive manner.
Octamer transcription factor @number@ ( @date@ is a ubiquitous member of the POU-homeodomain family that functions as a coregulator of AR.
OCT angiography ( OCTA ) was used to image the retinal microvascular network.
OCT B-scans were compared to light microscopy images of the same cross section.
Octogenarians ( ≥80 years ) were stratified into isolated primary coronary bypass graft , aortic valve , mitral valve , or combined operation.
Octogenarians living in the community are the fastest-growing demographic in Canada.
Octogenarians may benefit from surgical treatment of NSCLC with an acceptable morbidity and mortality rate , if an accurate preoperative selection is pursued.
Octogenarians performed significantly better than centenarians on all FOME measures.
Octreotide significantly increased the proportion of apoptotic Caco-2 cells.
Ocular , corneal , and internal HOAs were measured in micrometers.
Ocular perfusion pressure ( OPP ) was calculated using the following equation : OPP = MAP - IOP.
Ocular response analyzer ( ORA ) , HRT3 , and GDxVCC measurements were taken at the research clinic.
Ocular vestibular evoked myogenic potentials ( oVEMP ) represent extraocular muscle activity in response to vestibular stimulation.
Odds of antiretroviral possession were @percent@ higher in months when patients had a prior-month supply of bipolar medication.
Odds of depressive symptoms were lower among some sexual minority women at older ages.
Odds ratio for having an advanced polyp in a patient with MetS compared to a patient without MetS was @number@
Odds ratio ( OR ) of association were calculated in logistic regression models that adjusted for potential confounders.
Odds ratio ( OR ) was calculated by multivariate regression models using coronary calcium score ( CCS ) categories and FMD as dependent variables.
Odds ratio ( OR ) was reported ( @percent@ confidence interval [ CI ] ) .
Odds ratios and @percent@ confidence intervals ( CI ) were calculated using conditional logistic regression.
Odds ratios for the presence of dementia on death certificates were calculated.
Odds ratios of type @number@ diabetes diagnoses are higher only among male cigarette smokers and heavy alcohol drinkers.
Odds ratios ( OR ) and @percent@ confidence intervals ( 95%CI ) were estimated using multivariable logistic and partial ordinal logistic analyses.
Odds ratios ( OR ) and @percent@ confidence intervals ( CI ) were calculated using multivariable-adjusted logistic regression models.
Odds ratios ( OR ) for SCC associated with degree of photoaging were estimated using logistic regression analysis adjusted for potentially confounding factors.
Odds ratios ( OR ) of associations were calculated in logistic regression models that adjusted for potential confounders.
Odds ratios ( OR ) quantified the estimated effects of covariates on progression risk at any given time.
Odds ratios ( ORs ) and @percent@ CIs were calculated using multivariable logistic regression ; and hazard ratios , using Cox proportional hazards regression.
Odds ratios ( ORs ) and @percent@ confidence intervals ( CIs ) were calculated with logistic and ordinal logistic regression.
Odds ratios ( ORs ) and @percent@ confidence intervals ( CIs ) were used to quantify the strength of the associations among the variables.
Odds ratios ( ORs ) for diabetes or prediabetes indicated by American Diabetes Association criteria were calculated for men and for pre- and postmenopausal women.
Odds ratios ( ORs ) versus nondrinkers for each risk factor and metabolic syndrome were compared between the younger and older groups.
Odds ratios ( ORs ) were calculated to identify demographic characteristics and common ED diagnoses associated with elder abuse.
Odds ratios ( ORs ) with corresponding @percent@ confidence intervals ( CIs ) were calculated.
Odds ratios ( OR ) were calculated via logistic regression models.
Odds ratios ( OR ) with @number@ % confidence intervals ( CI ) were reported when applicable.
Odds ratios ( @percent@ CI ) were determined to quantify associations using logistic regression.
Odds ratios ( @percent@ confidence intervals ) adjusted for demographics , follow-up time , risk factors and serum vitamin D were reported.
Odds ratios show increasing association with levels of alcohol misuse groups in males , low-educated , and tobacco users.
Odds ratios were used to compare the occurrence of health deficits in the least frail group to the remaining group.
Odds ratios with @percent@ confidence intervals were calculated.
Odontoblasts are long-lived post-mitotic cells in the dental pulp , whose function is to form and maintain dentin.
Odontoblasts were found to develop an autophagic-lysosomal system organized mainly by large autophagic vacuoles that are acid-phosphatase-positive to various degrees.
Odontoid fractures are the most common cervical fracture type among the elderly population.
Odor identification ability and cognition were measured in a population-based cohort of @number@ very old twins and singletons , including @number@ centenarians.
Odor identification scores ranged from @number@ to @number@ correct ( mean = @number@ standard deviation = @number@ ) .
Odor identification was measured via a mailed survey.
Odor identification was measured with a 5-item version of the Sniffin ' Sticks ( 0-5 correct ) .
Oedema should not be used to diagnose HF in older persons.
Oesophago-gastric junction ( OGJ ) competence , oesophageal clearance mechanisms and reflux causticity are involved in GORD pathophysiology.
Oestrogen replacement therapy resulted in increased survival by @percent@ in @number@ years.
of air pollution factors was significantly associated with pterygium or pterygium recurrence ( each P > @number@ ) .
Of all administrations , @percent@ were errors with moderate or high potential for harm.
Of all analyzed factors , only caregiver's informant dementia rating significantly influenced caregiver grief.
Of all deaths , @number@ ( @percent@ ) were cardiovascular-related and @number@ ( @percent@ ) were non-cardiovascular.
Of all enteroinvasive pathogens , researched by molecular analyses , only Yersinia spp. was positive.
Of all five new markers only addition of NT-proBNP improved the C-statistic ( @number@ ( 95%CI @number@.61-0.74 , p = 0.023 ) ) .
Of all individuals , @percent@ ( n = @number@ ) exhibited at least one iris freckle.
Of all @number@ separate items of these questionnaires , @number@ were determined more by mobility than level of ID.
Of all seniors evaluated , @percent@ did not suffer falls.
Of all subjects , LM and FM were positively correlated with BMD at almost sites ( P < @number@ ) .
OF and IORF volumes increased until the @number@ years of age , and then decreased in both male and female groups.
Of a total of @number@ patients @number@ patients were over the age of @number@
of cognitive function with cumulative dose of smoking as well as with time since smoking cessation were substantiated by restricted cubic splines regression.
Of course , these results should be put in the context of the clinical picture and other diagnostic test results.
Of current hearing aid owners , @percent@ never used their aids.
OFC was the only brain region to significantly predict disinhibition , and MFG significantly predicted EF performance.
of disease controls or healthy subjects had positive results.
Of expected side effects , erythema was most common , occasionally being reported as high as a 2 ( scale 0-10 ) .
Offering a conservative pathway supported by palliative care is a reasonable option for some patients under these circumstances.
Offering an opportunity for open discussion of sexuality and medical assistance without imposing is a difficult balance.
Offering both pneumococcal and influenza vaccination to the elderly may improve 30-day mortality in patients with CAP.
Offering intervention to those individuals most vulnerable to impaired functioning may relieve some of the increasing pressure on the health care system.
Offering sleep interventions may help ameliorate pain , but treatment may need to be tailored by sex and ethnicity / race.
Office BP measurements ( OBPM ) might be unable to detect these BP variations.
Of five studies two controlled for confounders and one found a positive vaccination effect.
Off-label antipsychotics were used by @percent@ of patients with AD and @percent@ of patients with FTD.
Off-label prescribing should not be viewed as scientifically or ethically unsound when there are good clinical data to support a particular therapeutic indication.
Offspring born to older parents may experience different environments in terms of family support or inherited resources , factors often mediated by competition from siblings.
Offspring ( but not parents ) reported providing more frequent support to parents when parents were disabled.
Offspring of long-lived parents have a low prevalence of cardiovascular disease in middle age.
Offspring reported providing more frequent support than parents reported receiving.
Offspring were categorized into parental longevity groups based on gender-specific distributional cut points.
Offspring who reported informative parental communication and comparisons did not differ in perceptions of aging.
Offspring who reported intrusive parental communication about the Holocaust perceived themselves as aging less successfully and were more anxious of aging and death than comparisons.
Of HbA1c change toward treatment goal value , @percent@ is reached in about @number@ days.
Of importance , satellite cells are 17β-estradiol ( E2 ) and testosterone ( T ) targets.
Of importance to occupational therapists is the recent appeal to understand older adults ' ordinary ways of everyday living.
Of individuals with an MMSE less than @number@ poorer cognition was associated with fewer physician visits.
Of individuals with prediabetes at baseline , @percent@ progressed to T2D.
Of interest , cell death was not prevented under culture conditions modeling chronological aging , suggesting that DUT-M only protects dividing cells.
Of interest is the p.T194M , CytB substitution in the lower extreme of AEE occurring at a residue in the Qi site of complex III.
Of interest , the observed P1 amplitude reduction was larger in older adults.
Of interest were the risk and protective factors that differed by sex.
Of interest , young age and premature birth were independently associated with attenuated RIG-I-dependent IFN-α responses ( p < @number@ ) .
Of key importance was access to training that facilitates knowledge transfer and supports practice change , interprofessional collaboration , and ongoing infrastructure support.
Of men in the study , @percent@ had persistent and intrusive pain , @percent@ were worried about their health , and @percent@ had anxiety.
Of note , 52·6% of nurses advocated the use of steel needles , a potentially dangerous practice.
Of note , analogous changes were observed in the hippocampus of postmenopausal women.
Of note , autophagy is crucial for YAP to protect MCF7 cells from apoptosis under ND conditions.
Of note , Cr contaminants in PN solutions can increase the amount delivered by 10%-100%.
Of note , diabetic patients also had lower CFR regardless of CAC score than nondiabetic patients after matching.
Of note , DKK-1 levels were significantly lower in peri- and postmenopausal women compared to premenopausal patients ( @percent@ ; p < @number@ ) .
Of note , estrogen receptor-α ( ER-α ) , an important negative regulator of ET-1 , was downregulated in P30 fibroblasts.
Of note , H2O2 is a second messenger in insulin signaling and in several growth factor-induced signaling cascades.
Of note , HS-1793 induced p53 / p21WAF1 / CIP1-dependent apoptosis in MCF-7 cells , whereas it exhibited p53-independent apoptosis in MDA-MB-231 cells.
Of note , increased neuronal DNA content did not relate to the deposition of Lewy bodies in any region examined.
Of note , OT and oxytocin receptor knock out mice develop bone defects and late-onset obesity.
Of note , OTC outcomes appear better when a hearing health care professional supports these users.
Of note , peripheral blood contains only @percent@ of the total body lymphocyte population.
Of note , the association between stress and BDNF was only observed in subjects without insomnia.
Of note , the FAH superfamily includes many prokaryotic members with very distinct functions that lack homologs in eukaryotes.
Of note , the inhibition of NOX2 has been found to be protective for cardiovascular homeostasis.
Of note , their presence is often accompanied with cognitive decline and the risk of dementia.
Of note , the significant impact of sleep on suicide ideation is indirect via depressive symptoms , cognitive failures , medication non-adherence and life dissatisfaction.
Of note , we found that cell cycle progression is necessary for the DDR-resistant MYOD mutant to reverse senescence-mediated inhibition of the myogenic program.
Of note , we found that expression of several of these markers correlated with increased survival in different tumours , especially in breast cancer.
Of @number@ abstracts returned , @number@ studies were examined in full text with @number@ eligible for systematic review.
Of @number@ aging-related phenotypes , no significant association with genotype was seen.
Of @number@ articles identified , @number@ satisfied selection criteria and were included in our analysis.
Of @number@ articles , @percent@ idealized sexuality ( sexual attractiveness and optimal sexual engagement ) for older adults.
Of @number@ articles screened , @number@ were included in this systematic review.
Of @number@ C. elegans orthologs , knockdown of @number@ enhanced both Aβ and polyQ-associated toxicity.
Of @number@ clinicians invited to the study , @number@ participated ( @percent@ ) .
Of @number@ completing follow-up , @number@ ( @percent@ ) sought further testing and @number@ ( @percent@ ) had used the information to enhance communication.
Of @number@ confirmed cases , @number@ ( @percent@ ) were males and @number@ ( @percent@ ) were females.
Of @number@ CRC patients with a median follow-up of @number@ years , @number@ ( @percent@ ) used beta-blockers prior to diagnosis.
Of @number@ deaths , @percent@ were from lung cancer and @percent@ from chronic obstructive pulmonary disease.
Of @number@ early complications , @number@ ( @percent@ ) were lymphovascular.
Of @number@ eligible patients , @number@ enrolled in the study.
Of @number@ enumerated people , @percent@ participated in a hospital-based ophthalmic examination.
Of @number@ GWAS of noncommunicable diseases identified , summary data from @number@ were available.
of @number@ HIV-infected adolescent males and only three of @number@ HIV-infected females reported ever having had sex.
Of @number@ initial hits , @number@ studies of moderate methodological quality were eligible , including @number@ individuals with MGUS vs. @number@ controls.
Of @number@ menopausal women identified , @number@ were allocated to a study group and @number@ to a control group.
Of @number@ million study-eligible patients , @number@ had VTE.
Of @number@ PAD participants without baseline mobility impairment , @number@ ( @percent@ ) developed mobility loss during follow-up.
Of @number@ participants assessed ( mean age @number@ years , @percent@ female ) , @number@ ( @percent@ ) completed the six-month intervention.
Of @number@ participants at baseline , @number@ survived and were examined at VT3.
Of @number@ participants , @number@ had been exposed to ELS , namely to temporary separation from both parents in childhood.
Of @number@ participants , @number@ ( @percent@ ) were elderly and had a higher risk of adverse events compared with younger patients.
Of @number@ participants , @number@ were anemic ( hemoglobin ≤12.7 g / dL ) , @number@ of whom had no known cause.
Of @number@ participants with dementia who took antimuscarinics , @percent@ ( @percent@ CI = 13-19% ) were simultaneously taking other medicines with anticholinergic properties.
Of @number@ participants with MCI , @number@ ( @percent@ ) self-reported a head trauma.
Of @number@ patients enrolled , @number@ @number@ @number@ and @number@ received @number@ @number@ or @number@ mg cadazolid BID or @number@ mg vancomycin QID , respectively.
Of @number@ patients in the cohort , a total of @number@ met the criteria and @number@ ( @percent@ ) were classified in the Low-CD4 group.
Of @number@ patients in the OAT maintenance phase , @number@ were older than @number@ years ( mean age @number@ years ) .
Of @number@ patients , @number@ ( @percent@ ) were geriatric.
Of @number@ patients , @number@ received prophylaxis with ITCZ-OS at a dose of @number@ mg / day , and @number@ did not.
Of @number@ patients , @number@ were male and @number@ were female , aging 42-89 years ( mean , @number@ years ) .
Of @number@ patients , @percent@ ( 95%CI : @number@.3%-23.7% ) patients had a stroke recurrence , and @percent@ ( @percent@ CI : @number@.0%-36.2% ) died.
Of @number@ patients screened , @number@ were eligible.
Of @number@ patients who developed dementia , the estimated mean age at onset was @number@ years.
Of @number@ patients with carotid sinus hypersensitivity , the median age ( IQR ) was @number@ ( 68-82 ) years.
Of @number@ patients with comorbid depressive disorders , @number@ were randomized to the trial.
Of @number@ potentially relevant studies , @number@ trials of botanical extracts for reducing skin wrinkling and the appearance of aging met all the inclusion criteria.
Of @number@ pregnancies in @number@ women , @number@ live newborns were delivered.
Of @number@ records , @number@ studies involving @number@ participants met the review's inclusion criteria.
Of @number@ referent women , @number@ developed glaucoma.
Of @number@ referred people who were born in @number@ @number@ were randomized to an intervention group or a control group.
Of @number@ relevant articles screened , @number@ met the predefined inclusion criteria.
Of @number@ respondents ( @percent@ ages @number@ to @number@ @percent@ male ) , @number@ ( @percent@ ) were sexually active.
Of @number@ RING E3 ligases examined computationally , our model predicted @number@ EI24 targets.
Of @number@ Sgf73 binding sites , @number@ correspond to @number@ regions of genes implicated in RLS extension , including @number@ genes encoding RPs.
Of @number@ single-donor apheresis donations between @number@ and @number@ none of the @number@ donors had a confirmed positive result for any pathogen.
Of @number@ studies identified in our comprehensive database search , @number@ were selected for inclusion.
Of @number@ telephone screens , @percent@ were eligible for further screening.
Of @number@ valid addresses of survivors at follow-up , the follow-up response rate was @percent@ ( @number@ ) .
Of @number@ women sent the tool , @number@ provided acceptability feedback.
of our inflammatory markers predicted future depressive state or cognitive decline in our community-dwelling healthy older sample.
of our @number@ PD cases carried CHCHD2 mutations , whereas @number@ sporadic PD patient showed the Pro34Ser substitution in CHCHD10.
of our patients showed signs of myopathy at electrophysiological examination.
Of participants with clinical signs of ocular disease , @percent@ had HRindex values outside the normal limits.
Of participants with dementia with a rehospitalization within @number@ days , @percent@ had been discharged to nursing facilities from the index hospitalization.
Of participants with normal ALM , strength , and performance , @percent@ transitioned to presarcopenia and none transitioned to sarcopenia.
Of particular concern is the recent emergence of multidrug-resistant organisms among this vulnerable population.
Of particular importance , a multifaceted exercise intervention combining active-assisted cycling and resistance training to older adults diagnosed with Parkinson's disease is being assessed.
Of particular importance is how the brain removes potentially toxic biomolecules that accumulate with normal neuronal function.
Of particular importance is the recognition that L5 has relatively different morphology when compared with more cranial levels.
Of particular importance , the magnitude of association system segregation is predictive of long-term memory function , independent of an individual's age.
Of particular interest is influenza because China and Southeast Asia lie at the center of a global transmission network of influenza.
Of particular interest was how retrieval difficulty differed across young and older adults and across manipulations of lag ( Exp.
Of particular interest was that the positive impact of social support was most pronounced in the moderate health risk group.
Of particular note , this significant association between the FTO risk allele and LTL appeared only in nonobese subjects ( P = @number@ ) .
Of particular potential is the combination of MI with neurofeedback ( NF ) .
Of particular significance is the existence in some species of a distinct period of postreproductive life.
Of particular significance is the support and friendship the women offer each other through their commonalities , activities , and sense of humor.
Of particular significance , the \ "graying of America \ " promises new challenges and opportunities for health care social work.
Of patients who seek help with their symptoms , almost one-third do not respond to the medical therapy.
Of patients with a history of onabotulinumtoxinA injections ( @percent@ in phase I and @percent@ in phase II ) , the majority preferred onabotulinumtoxinA.
Of possible complications , only vaso-occlusive crisis , asthma , or avascular necrosis diminished SF-36 scale scores.
Of previously published significant GWAS SNPs , @percent@ are identified to be significant eQTLs in our study.
Of relevance , oral administration of recombinant calf IAP prevents the dysbiosis and protects the gut from chronic colitis.
Of relevance , short hairpin RNA Lamin A / C depletion in unmethylated neuroblastoma cells enhanced the aforementioned tumour properties.
Of remaining , HADS were recorded for @number@ ( @percent@ ) patients.
Of respondents currently at GWEP sites ( @percent@ ) , only @percent@ report a GWEP budget including GACA-like support.
Of responders , @percent@ were of the opinion that a clinical assessment tool would be of benefit in assessing FTD.
Of six compounds , MHY2013 was screened as the strongest activator of three PPAR subtypes based on protein docking simulation and luciferase assays.
Of six studies assessed , lifestyle interventions were consistently successful at improving the inflammatory and metabolic profiles.
Of special concern are developmental exposures that can disrupt later-in-life adult health or aging.
Of special importance is the maintenance of nuclear protein homeostasis to ensure a coordinated cellular metabolism.
Of special note is that accumulating data suggest an intimate relationship between autophagy and ovarian carcinoma.
Often a combination of different techniques allows individualized treatment with optimal outcomes.
Often adult women continue this bad habit and bladder dysfunction may consolidate.
Often , it is difficult to identify a single underlying cause , and when a diagnosis is made , therapeutic options may be limited.
Often , MBL2 secretor genotypes did not match functional deficiency , suggesting that functional MBL deficiency can be an acquired condition.
Often overlooked components of chronic disease management include symptom control and assessment of health-related quality of life ( HRQoL ) .
Often studies aimed at increasing our understanding of cellular senescence take advantage of model systems.
Often , surgery is not an option for patients with multiple comorbidities , and conventional drugs either have many side effects or are ineffective.
Often the patients need to stay on an atypical antipsychotic because of the mental health symptoms which they present.
Often , these tissues show the first signs and symptoms of drug toxicity and adverse effects.
Often they are due to respiratory or cardiac motion artifacts.
Of the age-related variance in cognition , 70-80% was accounted for by combining all brain markers ( but only ∼20% of total variance ) .
of the analysed SNPs was associated with CAG.
of the analyzed co-morbidities showed a trend towards increasing prevalence with COPD severity , except for nutritional problems.
Of the approximately @number@ million people in sub-Saharan Africa aged ≥ @number@ years that were HIV + , @percent@ were ≥ @number@ years old.
of the Asian target countries that attract reverse migrants have adequate health care and social safety nets that are available to them.
of the candidate genes in the new PARK10 region have been previously implicated in the biology of PD , suggesting new areas of potential research.
Of the cases whose average age is @number@.2±6.9 , @number@ of the @number@ cases were diagnosed as ill.
Of the CES-D sub-scales , Depressed Mood and Interpersonal Difficulties were significantly heritable , while only Well-Being had a significant genetic correlation with ME.
of the changes in diary variable outcomes differed by treatment group after accounting for these changes between baseline and @number@ weeks.
of the characteristics of religiousness was significantly associated with depressive mood or anxiety , as estimated by the proxy respondent.
Of the children , @percent@ had maternal reported PTE.
Of the chronic pain patients , @percent@ received opioids for moderate to severe pain , @percent@ received coanalgesics.
Of the clinical components of metabolic syndrome , central obesity was significantly associated with pain ( OR @number@ @percent@ CI @number@.36-3.01 ) .
Of the clinically used drugs in Alzheimer's disease , anticholinesterases have been shown to slow down the rate of progression of hippocampal atrophy.
Of the cognitive domains , executive function was the most vulnerable to decline.
Of the cohort , @number@ men ( @percent@ ) had @number@ different AR mutations reported.
of the commercial preparations tested had detectable antioxidant content , and none showed the UV absorption characteristics of natural reflex tears.
of the community characteristics were related to life satisfaction and self-perceived health , nor was degree of rurality.
of the control samples showed this variation.
Of the current @number@ million cancer survivors in the United States , most are @number@ or older.
Of the dentate , @percent@ had active dental caries.
Of the dropout miRNAs , we found that miR-574-3p expression was downregulated in clinical breast cancer tissues as compared with their paired adjacent tissues.
Of the drugs approved by the US FDA , none are disease modifying , only symptomatic.
Of the eight eligible studies identified with these criteria , four assessed energy expenditures and four assessed physical functioning.
Of the eight tube-fed patients of this group , three began direct swallowing exercises using jelly , which subsequently restored their oral food intake.
Of the enrolled @number@ African Americans , @number@ were identified in the EMR.
of the factors examined was associated with diastolic BP change.
Of the five who had renal scarring or severe obstruction , four became symptomatic.
of the food groups were associated with bone loss in both measured sites in women.
Of the four patients with invasive fungal infections , three had concomitant chronic illness such as diabetes.
of the gait measures predicted risk of single falls.
Of the high PiB HCs , @percent@ developed MCI or DAT by @number@ months and @percent@ by @number@ years.
Of the imputed scores , @percent@ were within @number@ point of their true value.
Of the indices that were studied VCmax and ACmax are governed mainly by the action of the Parasympathetic Nervous System.
of the individual comorbidities or indexes were correlated with the efficacy of PR.
Of the inducible miRNAs in this subfamily , miRNA-125b is among the most abundant and significantly induced miRNA species in human brain cells and tissues.
Of the insulin exposures , @number@ were unintentional therapeutic errors ( @percent@ ) .
of the isolated SMMS patients had muscular suspension dehiscence or required reoperation.
Of the items screened in the questionnaire , weight , height and previous history of fragility fracture were predictive of osteoporosis.
of the items showed Differential Item Functioning associated with age , gender , or education.
of the leg PLMS parameters were different between the ALS patients and controls.
Of the liveborn infants , @percent@ died before @number@ days of age and @percent@ before @number@ months of age.
Of the many theoretical definitions of frailty , two are commonly employed : the physical frailty / phenotypic approach and the deficit accumulation approach.
Of the markers assessed , IL-6 is most robustly associated with incident disease , disability and mortality.
of the materials affected bacterial growth in solution.
of them complained of nasal symptoms.
Of the metabolic syndrome criteria , the highest incidence was registered for the essential hypertension.
of the metabolites identified are associated with cancer risk.
Of the mitogen-activated protein kinases ( MAPKs ) , EGb inhibited only c-Jun N-terminal kinase ( JNK ) .
Of the MMPs elevated with cardiac aging , MMP-9 has been extensively evaluated and its roles are reviewed here.
Of them , @number@ among men and @number@ in women were cases of incident severe depression.
Of them , @number@ ( @percent@ ) had EE complications.
Of them , @number@ were cognitively normal ( control group ) , @number@ had mild cognitive impairment ( MCI ) , and @number@ had dementia.
Of them , @number@ were considered selectable.
Of them , @number@ were males.
Of them @number@ were re-assessed in @number@
Of them , @number@ women were considered to be premenopausal , @number@ were perimenopausal , @number@ were naturally postmenopausal , and @number@ were surgically postmenopausal.
of the MRI findings was significantly associated with the gender , smoking , sports activities , or BMI.
of the MS components could predict AF attack.
Of them twenty-five variants ( seven loci newly reported ) are proposed as MetS candidates.
Of the NIH's $ 45 billion directed to HF research , only $ 14 million ( @percent@ ) was spent on palliative care research.
Of the nondialysis patients , @percent@ had stable or improved symptoms over @number@ months and @percent@ had stable or improved QOL.
Of the @number@ articles , a mere @percent@ ( n = 23 ) were devoted to skin.
Of the @number@ articles found , @number@ investigations matched the inclusion criteria.
Of the @number@ articles that were identified by our search strategy in the Medline database , @number@ were retained.
Of the @number@ baseline participants , @number@ ( @percent@ ) died over the @number@ years.
Of the @number@ baseline sample , @number@ ( @percent@ ) were successfully followed up after approximately @number@ months.
Of the @number@ cases conducted via ED visit , @number@ ( @percent@ ) were admitted to the hospital and @number@ ( @percent@ ) died.
Of the @number@ cases with C9ORF72 mutation , @number@ exhibited well-defined delusions.
Of the @number@ clients , @number@ participated in the test-retest reliability study.
Of the @number@ community-dwelling individuals , @number@ were found to have MCI.
Of the @number@ Delphi panelists , @number@ were DCs and @number@ were other health care professionals.
Of the @number@ detected exonic variants in SQSTM1 , the majority were rare ( n = @number@ ) .
Of the @number@ ears with audiometric data available for review , @percent@ exhibited sensorineural hearing loss , and @percent@ mixed hearing loss.
Of the @number@ eligible articles , studies reporting community integration outcomes post-TBI were identified and critically reviewed.
Of the @number@ eligible respondents , @number@ returned filled-in questionnaires ( @percent@ response rate ) .
Of the @number@ enrolled dyads , 18completed post-treatment assessments ( i.e. @number@ intervention and @number@ comparison group ) .
Of the @number@ fungal strains , @number@ were Penicillium strains.
Of the @number@ genes that affected lifespan , @number@ were previously unreported.
Of the @number@ geriatric rhesus macaques evaluated , @number@ ( @percent@ ) fulfilled the criteria for diastolic dysfunction.
Of the @number@ included studies , @number@ had at least one significant outcome.
Of the @number@ included studies , @number@ were cohort studies with a control group and @number@ were case series.
Of the @number@ individuals enrolled , @number@ completed the evaluation.
Of the @number@ individuals , @percent@ attended the ED within @number@ days and of those @percent@ lived alone.
Of the @number@ interviewed patients @number@ were female and @number@ male.
Of the @number@ LonGenity subjects , @number@ were OPEL and @number@ were OPUS.
of the @number@ low quality studies reported positive impact of case management on the outcomes of interest.
Of the @number@ lysines ( K ) least is known about effects of modification of K6.
Of the @number@ million people diagnosed with pleural effusion in the USA annually , ~178 @number@ undergo thoracentesis.
Of the @number@ @number@ ( @percent@ ) completed the 12-week treatment period , and four dropped out for vestibular burning.
Of the @number@ @number@ ( @percent@ ) CPLs increased to diameters ≥ @number@ cm at the final follow-up.
Of the @number@ @number@ subjects aged 18-59 years old , information on frequency and duration of leisure activity was collected by face-to-face interview.
Of the @number@ papers , only @number@ studies ( @percent@ ) included any mention of hearing loss.
Of the @number@ participants in CHAP , @number@ were reported to social services agency for suspected elder self-neglect from @number@ to @number@
Of the @number@ participants in the Chicago Health and Aging Project , @number@ participants were reported to social services agency for suspected elder self-neglect.
Of the @number@ participants , @number@ had an evaluable MRI.
Of the @number@ participants , @number@ participants completed the Epworth Sleepiness Scale questionnaire.
Of the @number@ participants , @number@ ( @percent@ ) presented with PHG.
Of the @number@ participants who enrolled , @number@ ( @percent@ ) completed the study.
Of the @number@ participants who reported having right knee pain , @number@ had a short right leg and @number@ had a short left leg.
Of the @number@ participants who were hospitalized for a fall-related injury , @number@ had diabetes , and @number@ were using insulin.
Of the @number@ participants who were nonfrail at Wave @number@ @number@ ( @percent@ ) were frail by Wave @number@
Of the @number@ participants with CCM , @number@ ( @percent@ ) had a single Zabramski type @number@ lesion in a supratentorial location.
Of the @number@ participants with complete data , @number@ subjects ( @percent@ ) were classified as demonstrating MPS.
Of the @number@ patients in the entire samples , @percent@ were males , @percent@ were married , and @percent@ were Chinese.
Of the @number@ patients , @number@ had weight measurements at admission and discharge : @number@ ( @percent@ ) had ≥5% weight loss.
Of the @number@ patients , @number@ ( @percent@ ) were also treated with other ( nonpermanent ) fillers without incident.
Of the @number@ patients , @number@ with stage I to III disease aged @number@ years or over at BC diagnosis were enrolled into this study.
Of the @number@ patients , one with nuclear cataract showed homozygosity and the remaining five showed heterozygosity for the substitution.
Of the @number@ patients , @percent@ were female , @percent@ benefited from the treatment , and @percent@ discontinued the medication.
Of the @number@ patients who completed the study , @number@ were classified as a treatment success.
Of the @number@ patients who died during hospitalization , @number@ were hypogonadic.
Of the @number@ patients who were delirious in the ED , @number@ ( @percent@ ) patients ' delirium persisted into hospitalization.
Of the @number@ patients with AWP , @number@ were male and @number@ were female.
Of the @number@ peptides correlating with age , @number@ had a strong homology to the respective human age-related peptides.
Of the @number@ ( @percent@ ) patients with dementia , @percent@ were catheterized.
Of the @number@ persons with depressed mood at baseline , @number@ ( @percent@ ) experienced remission during follow-up.
Of the @number@ persons with known ApoE ε4 status in @number@ @number@ had died at the end of the 10-year follow-up.
Of the @number@ pharmacy discrepancies identified , @percent@ involved an omission of a medication.
Of the @number@ probands , @number@ were identified to harbor the p.P102L mutation within PRNP.
Of the @number@ randomized participants , @number@ had follow-up data on efficacy outcomes.
Of the @number@ remaining schools , @number@ responded and @number@ provided analysable data.
Of the @number@ respondents that participated in KLoSA in @number@ @number@ adults aged between @number@ and @number@ years were included in the final analysis.
Of the @number@ single-nucleotide polymorphisms ( SNPs ) , @number@ were associated with age of onset and another @number@ SNPs were borderline associated.
Of the @number@ skin product advertisements , less than @percent@ of the products contained sun protection factor ( SPF ) .
Of the @number@ student nurses , @number@ completed the survey ( a response rate of @percent@ ) .
Of the @number@ studies , @number@ with comparable methodology were eligible for a meta-analysis.
Of the @number@ subjects eligible for enrollment , @number@ subjects comprised the study group and @number@ subjects comprised the validation group.
Of the @number@ subjects included in the study , @number@ ( @percent@ ) were identified as an HS-Aging case.
Of the @number@ subjects in this category identified , six were men and eight were women.
Of the @number@ subjects with MCI that were re-examined , @number@ converted to AD.
Of the @number@ survivors , @number@ ( @percent@ ) recovered to their baseline eGFR.
Of the @number@ trials , @number@ studies reported findings of pharmacist-led medication reviews and @number@ reported findings of multidisciplinary team-based reviews.
Of the @number@ women who had already had a major osteoporotic fracture , one-third ( @number@ % ) were not taking any osteoporosis medication.
of the nutrients were associated with BMD loss in both measured sites in women.
Of the obese children , @percent@ improved to normal weight status , @percent@ improved to overweight status and @percent@ remained as obese in @date@ .
of the oils tested displayed cytotoxic effects.
of the older adults who were never mentally ill developed a depression.
of the online measures was positively associated with the pen and paper screening measures.
of the operated patients had a recurrence and the incidence of complications was @percent@.
Of the opiate dependent group , @percent@ were treated with buprenorphine , @percent@ with methadone , and @percent@ with naltrexone.
Of the original UBCS , n = @number@ children ( ~ @percent@ of the original sample ) and their parents participated in the 11-year follow-up.
of the other AD risk genes influenced AAO of AD.
of the other blood type percentages had a statistically significant increase or decrease.
of the other cognitive ability measures were related to intervention group.
of the other parameters were significantly affected by age or gender.
of the other pathologic markers was related to either of the depression measures.
of the other seven geriatric conditions assessed were associated with ADR risk.
Of the overall total , @percent@ were for diseases of the blood and blood-forming organs ( D50-D89 ) .
of the parameters differed significantly between the right and left sides of the mandibular fossa in males , females , or all subjects.
of the participants ' characteristics nor any of the outcome variables differed between groups at baseline.
of the participants had focal scar on delayed enhancement CMR.
Of the participants , @number@ had prevalent type @number@ diabetes in old age.
of the patients carrying SQSTM1 mutation showed clinical evidence of concomitant Paget disease of bone or mutation of the valosin-containing protein gene.
of the patients developed postoperative infections.
of the patients fulfilled the lactic acidosis criteria.
of the patients had a past history of cardiac disease.
of the patients had the CC genotype.
of the patients in group @number@ and controls showed the appearance of StCA or ovarian dysfunction during the follow-up.
of the patients reported anastomotic leakage.
of the patients who underwent laparoscopic peritoneal lavage showed recurrent disease.
Of the patients with CD , @number@ ( @percent@ ) had MCI , @number@ ( @percent@ ) AD , and @number@ ( @percent@ ) VaD.
Of the @percent@ of subjects who showed improvement in Fitzpatrick wrinkle scores , @percent@ continued to have improvement at the 6-month follow-up visit.
of the physical performance measures affected TMIG-IC score declines in men.
Of the potential outliers , @number@ ( @percent@ ) were confirmed as physicians with unusual performance at a false discovery rate of @percent@.
Of the predialysis patients , @number@ ( @percent@ ) commenced dialysis.
of the PRS was associated with breast cancer risk.
of the PTH hormone system genes were associated with vertebral fracture.
Of the pt , @percent@ had morbidity in Poland and @percent@ in Italy.
Of the readmissions , @number@ had RCA from both the hospital and SNF.
Of the remaining @number@ patients , ABO types were available for @number@ ( @percent@ ) .
Of the remaining @number@ patients , @number@ with CSM whose condition could be evaluated @number@ months after surgery were analyzed.
Of the remaining @number@ subjects , only @number@ or @percent@ overall had at least a 4-fold increase by Day @number@
Of the remaining patients with plaques , four showed a reduction of the previously diagnosed plaque ; no patients worsened.
Of the respondents , only persons who had a diagnosis of dementia were included in this analysis ( N = 2379 ) .
Of the respondents , @percent@ were women.
of the results were significant after applying a Bonferroni correction.
Of the schools reached , @percent@ reported intergenerational programming.
Of these , 454 / 526 ( @percent@ ) completed MRA-O assessments.
of these associations passed Bonferroni correction.
Of these candidates , pancreatic polypeptide ( PPY ) and IgM showed a significant association with NAB.
of these children was deficient in essential elements.
Of these , clozapine is effective but is associated with a poor side-effect profile and the necessity for frequent blood draws.
Of these deaths , @number@ million are due to heart attacks , and @number@ millions are due to stroke.
of these effects are altered by pharmacological CDC42 inhibition.
of these formulations contained an optical absorber in the IR range.
Of these groups , @number@ men in the testosterone group and @number@ men in the placebo completed the memory study.
of these hepatic measures demonstrated age-dependent relationships on a per microsomal protein basis using linear regression models.
of these hormones was significantly associated within or across trials with FACIT-Fatigue , PHQ-9 Depression or Physical Function-10 scores , or gait speed.
Of these images , @number@ images were gradable ( @number@ images of the right eye and @number@ images of the left eye ) .
Of these limited interventions , most were exercise interventions with only limited testing.
Of these measures , reporting whole-grain intake in grams is essential for future research work in the area.
Of these medicines , nortriptyline and oxybutynin were more frequently prescribed in individuals taking donepezil.
Of these , more than @percent@ of patients received sliding scale insulin in co-administration with basal insulin.
Of these , most ( @percent@ ) were in \ "stage 3 \ " , which corresponds to amyloid pathology with early neurodegeneration.
Of these , @number@ accepted the first dose of the vaccine and @number@ ( @percent@ ) completed the vaccination schedule.
Of these , @number@ adults , @number@ years and older ( mean @number@ SD @number@ ) , were eligible for analysis.
Of these , @number@ are approved for use by the US Food and Drug Administration.
of these @number@ cases was diagnosed with PE in CTPA , the false-negative rate was @percent@.
Of these , @number@ cases were @number@ years of age or older , and these @number@ cases were enrolled into further study.
Of these , @number@ developed ischemic vascular disease during follow-up.
Of these , @number@ from HC1 and @number@ from HC2 were identified by mass spectrometry.
Of these , @number@ had beneficial results of exercise in Alzheimer's disease.
Of these , @number@ had self-reported their weight twenty years earlier and among these @number@ had also had their weight assessed at this time point.
Of these , @number@ met our quality control standards.
Of these @number@ @number@ waned at least 4-fold , and @number@ others 2-fold.
Of these , @number@ original studies , involving @number@ to @number@ participants , met the inclusion criteria and were included in the systematic review.
Of these , @number@ participated in a questionnaire follow-up in @number@ and in a subgroup of @number@ women lung function was tested in 2008-2009.
Of these , @number@ patients had at least one of the @number@ selected diseases or conditions.
Of these @number@ patients , @number@ ( @percent@ ) had transient AKI , and @number@ ( @percent@ ) had persistent AKI.
of these @number@ patients relapsed during the entire follow-up period of 3-36 months.
Of these , @number@ patients were aged less than @number@ years and @number@ patients were aged @number@ years or greater.
Of these , @number@ patients were eligible for intention-to-treat analyses.
Of these , @number@ patients were excluded and the final cohort included @number@ children with @number@ MRI studies.
Of these , @number@ patients were initiated on typical antipsychotics and @number@ patients were initiated on atypical antipsychotics.
Of these , @number@ patients were intubated at some point in their medical ICU stay , whereas @number@ were never intubated.
Of these , @number@ ( @percent@ ) developed dementia compared with @number@ patients with NTT ( @percent@ ) ( P < @number@ ) .
Of these , @number@ ( @percent@ ) had a discharge heart rate of < 70 beats / min.
Of these , @number@ ( @percent@ ) in the study group and @number@ ( @percent@ ) in the control group underwent further evaluation for PE.
Of these , @number@ ( @percent@ ) medical records met the study criteria.
Of these , @number@ ( @percent@ ) preferred home and @number@ ( @percent@ ) preferred a facility.
Of these , @number@ ( @percent@ ) were classified as at least FAST 7C.
Of these , @number@ ( @percent@ ) were fallers and @number@ ( @percent@ ) were recurrent fallers.
Of these , @number@ ( @percent@ ) were involved in fewer than five procedures.
Of these , @number@ ( @percent@ ) were males and @number@ ( @percent@ ) females.
Of these , @number@ ( @percent@ ) were ≥ @number@ years of age.
Of these , @number@ ( @percent@ ) were reexamined in 2013-2014.
Of these , @number@ ( @percent@ ) were taking antiplatelets and @number@ ( @percent@ ) OACs at the time of stroke.
Of these , @number@ procedures were performed for superfluous functional or nonfunctional leads.
Of these @number@ respondents a total of @number@ were natives which is the sample we selected for the current study.
Of these @number@ SDHs , @number@ ( @percent@ ) required surgical drainage.
Of these , @number@ showed a complete response , @number@ showed a partial response , @number@ remained stable , and @number@ developed local failure.
Of these , @number@ showed hypomethylation and @number@ showed hypermethylation with age.
Of these , @number@ studies provided data from care home residents.
Of these , @number@ studies were from long-term care facilities and two studies were from homecare settings.
Of these , @number@ were at higher levels in older tendon and @number@ were at lower levels in older tendon.
Of these , @number@ were available for survival analysis and @number@ for analysis of longitudinal diurnal consistency.
Of these , @number@ were had low body mass index ( BMI≤20 ) and were excluded.
Of these , @number@ were randomly selected to complete an additional @number@ months of follow-up ( T2 ; n = @number@ ) .
Of these , @number@ were smokers , @number@ were overweight , and @number@ were obese.
Of these , only 15 / 86 ( @percent@ ) were prescribed OAC.
Of these , only @number@ focused exclusively on resident-to-resident abuse.
Of these , only @number@ were caused by accidental poisoning ( likely drug overdose ) .
of these parameters were different neither between MetS and younger T2DM , nor between two sub-groups of subjects with T2DM.
Of these participants , @number@ started with FTC / TDF and @number@ with other nucleotide reverse transcriptase inhibitors ( NRTIs ) .
Of these participants , @percent@ had solid cancers , and @percent@ had a metastatic disease.
Of these , participants who reported social participation and psychological distress level in the baseline survey in @number@ were followed up.
Of these patients , @number@ patients had oral examinations on admission.
Of these patients , @number@ underwent metatarsal head-resurfacing hemiarthroplasty ( Group I ) and @number@ underwent TJR ( Group II ) .
Of these patients , patients with oral and maxillofacial trauma were chosen to be included in the research.
Of these patients , @percent@ ( n = @number@ ) had a high mFI ( > 0.27 ) .
Of these patients , @percent@ were illiterate / incomplete elementary school.
Of these , @percent@ had CWP and @percent@ had \ "some pain. \ "
Of these , @percent@ had diabetes mellitus , @percent@ had hypertension and @percent@ had hypercholesterolemia.
Of these , @percent@ had physician documentation of the sexual problem.
Of these , @percent@ had proven pertussis , and @percent@ were under @number@ year old.
Of these , @percent@ ( n = @number@ ) reported taking either BS or BDS.
Of these , @percent@ [ @number@.36%-1.77% ] had unilateral pseudophakia and @percent@ [ @number@.81%-3.37% ] had bilateral pseudophakia.
Of these , @percent@ sustained falls indoors , while @percent@ of falls occurred between @time@ @time@ .
Of these , @percent@ were catheterized , @percent@ received PCI , and @percent@ had coronary artery bypass graft ( CABG ) .
Of these , @percent@ were new users ( N = @number@ ) and @percent@ were continuing users ( N = @number@ ) .
Of these procedures , ablative laser resurfacing is the most precise technique and is considered the gold standard for facial skin rejuvenation.
Of these proteins , @number@ were significantly altered.
of these results could be accounted for by institutionalization , antipsychotic medication , or cognitive scores.
Of these results , @percent@ were considered valid for a statistical evaluation.
Of these , seven articles met all inclusion criteria and were analysed.
Of these , sex differences have been the most frequently studied , and most of the literature describes greater pain sensitivity for women.
Of these , specific IL-4 and IgE responses show the strongest associations with pemphigoid , pointing to an important contribution by Th2 cytokines to pathogenesis.
Of these studies , five included dementia patients and / or their partners , whereas only three studies included healthy older persons.
Of these studies , most have focused on individual functional polymorphisms or individual candidate genes.
Of these studies , @percent@ had results that were statistically favorable to intervention.
Of these technologies , intense pulsed light is the most commonly used because it effectively targets both the erythema and dyspigmentation seen in photoaging.
Of these , ten met the search criteria and were analyzed.
of these variables showed significant differences compared with a control group of @number@ fertile men.
Of the seven mammalian sirtuins , three localize to the mitochondria : SIRT3 , SIRT4 , and SIRT5.
Of these , we successfully generated three antibodies that preferentially recognise human compared with mouse SOD1 and RRP1 proteins on western blots.
Of the six men who had a mastectomy , five ( @percent@ ) had an AR mutation.
of the SNPs reached genome-wide significance.
Of the Soldiers who were not overweight or obese at accession , @number@ were eventually diagnosed as overweight or obese.
Of the students in this study @percent@ had completed coursework in elderly health as part of undergraduate study.
Of the studied amino acids , the strongest inverse association was observed between the phenylalanine concentration that was measured @number@ y earlier and the LTL.
Of the study participants , @number@ ( @percent@ ) developed the outcome and @number@ ( @percent@ ) died first.
Of the study subjects , @number@ had CSA proven and @number@ were non-CSA.
of the subjects experienced any serious adverse events during or after the procedure.
of the subjects reported dissatisfaction.
of the subjects showed IgM reactivity for CMV , excluding acute viral infection.
of the survivors met the guidelines for dietary fiber and potassium intake.
of the three characteristics of hardcore smokers for either gender showed a significant change from @number@ to @number@
of the three lifestyle parameters influenced the changes in cognition across time.
of the three proposed criteria identified any cases in the bereaved comparison group.
of the three proteins complex together using size exclusion chromatography.
Of the total cohort , @number@ completed standardized self-reported health questionnaires , which included questions on activities of daily living.
Of the total number of cases , @percent@ of subjects had bilateral CTS.
Of the total number of older adults , @percent@ used at least five medications ( polypharmacy ) .
Of the total patients , @percent@ were female.
Of the total population , @percent@ were retired , @percent@ employed , @percent@ not working , and @percent@ students.
Of the total population , those aged ≥75 years accounted for @percent@ as of @number@ and this is expected to reach @percent@ in @number@
of the transductional pathways explored seem to be involved.
Of the trials identified , @number@ RCTs met inclusion criteria , demonstrating an evidence base for stroke rehabilitation in the chronic phase as well.
Of the tweets , @percent@ contained humor , of which @percent@ related to compression.
Of the variables related to the study population that were compared to arteriography , two correlated with renal artery stenosis , renal dysfunction and triglycerides.
of the variants in the neuroinflammatory pathway studied were associated with incident mild cognitive impairment syndrome.
Of the various ingredients reviewed , niacinamide , green tea , licorice , and soy have the most published data for anti-aging and whitening activity.
of the VEP / ERP latencies showed a correlation to the triplet repeats of the SCA2 gene.
of the websites had any age restriction on access , references to government regulation or lawsuits.
Of the whole sample , the 25th percentile ( score = @number@ ) represented a valid index for possible deficits.
Of the women studied , @percent@ experienced IPV with an average duration of @number@ years.
Of the work that has been conducted to date , emphasis has been placed on psychotropic drug use.
of the young subjects exhibited this phenomenon.
Of this group , @number@ patients ( @percent@ ) died of CV disease.
Of this set , @number@ QIs were based on ACOVE QIs and @number@ QIs were newly added.
Of those characterized as \ "at-risk , \ " @percent@ used services compared to @percent@ of the \ "low risk. \ "
Of those deaths , the proportion occurring in hospital varied from @percent@ in the Netherlands to @percent@ in South Korea.
Of those diagnosed , the proportion receiving antidepressants increased from @percent@ to @percent@ , whereas the proportion receiving psychotherapy declined from @percent@ to @percent@.
Of those infected , many will develop asymptomatic gastritis , but @percent@ develop gastric or duodenal ulcers.
Of those , @number@ articles ( ≈79 , 500 patients ) met the inclusion criteria and were included in the review.
Of those , @number@ had undergone ex vivo imaging.
Of those @number@ patients , only two had a favorable course , while the others died early or progressed toward advanced chronic kidney disease.
Of those , @number@ ( @percent@ ) men received exogenous testosterone following their cancer diagnosis.
Of those , @number@ subjects had fecal elastase-1 level below @number@ μg / g as a marker of severe pancreatic insufficiency.
Of those , @number@ used the microtensile test evaluating @number@ adhesive systems ( AS ) .
Of those participants , @number@ attended at least @number@ of the @number@ sessions.
Of those , @percent@ developed major complications and @percent@ experienced prolonged length of stay ( LOS ) .
Of those providing handicaps , @number@ ( @percent@ ) reported the same or an improved handicap.
Of those responding , @percent@ reported having at least one chronic illness at the time of the survey.
Of those with biomarker results , @percent@ reported knowing their HIV status and accurately reported it.
Of those with diagnosed type @number@ approximately @number@ million ( @percent@ ) received diabetes medication-ranging from @percent@ in New Jersey to @percent@ in Utah.
Of those with follow-up information , only @number@ were cases with recurrences.
Of those with major depression , @number@ individuals reported clinically significant apathy , whereas @number@ participants did not have apathy.
Of those with multimorbidity who were screened , @percent@ had raised HADS ( ≥8 ) .
of three features was found significant differences between sexes , myopia , sleep deprived and normal subjects.
Of unique interest , the sex hormones appear to have a very strong influence on activity levels.
Of which , @number@ patients received combination therapy with Tamsulosin plus Finasteride and @number@ patients received monotherapy with Tamsulosin once daily at bed time.
Of which , @percent@ of elective admissions were for degenerative spine and @percent@ for functional / pain disorders.
OGG1 and MSH2 / MSH3 promote CAG repeat expansion at Huntington's disease ( HD ) locusin vivo during removal of oxidized bases from DNA.
OGG1 expression in lens cortex was analyzed by qRT-PCR and Western blot.
O-GlcNAcylated proteins influence fundamental functions of proteins such as protein-protein interactions , altering protein stability , and changing protein activity.
O-GlcNAcylated proteins occur in many different tissues and cellular compartments and affect specific cell signaling.
O-GlcNAcylation is dynamic and a ubiquitous post-translational modification.
O-glycan deficiency and the associated incapacity to extend serum half-life is a major drawback of the boCTP.
OGT and OGA mRNA levels were measured from muscle samples obtained at baseline and after one year.
OGT attaches an O-GlcNAc moiety to proteins , while O-GlcNAcase ( OGA ) catalyzes O-GlcNAc removal.
OH and OML were primarily differentiated by performance on the Short Physical Performance Battery ( SPPB ) .
OH is diagnosed with serial blood pressure measurements and the primary goal of management is to relieve unfavorable symptoms and enhance patient safety.
OHRQoL was statistically similar for people with or without dementia ( CONCLUSION : The OHRQoL of elderly nursing home residents is substantially compromised.
OH test included assessment of blood pressure and symptoms of OH.
OH was not associated with cognitive performance in non-SH subjects.
OI was defined as reporting feeling dizzy , light headed or unsteady during this test.
OLA1 directly bound to the amino-terminal region of BRCA1 and γ-tubulin.
OLA1 with a mutation observed in breast cancer cell line , E168Q , failed to bind BRCA1 and rescue the OLA1 knockdown-induced centrosome amplification.
Olanzapine had greater influences on adiponectin and total ghrelin than clozapine.
Olanzapine plus sertraline or olanzapine plus placebo were given until week @number@ or termination.
Old adults also performed tests of balance and walking endurance.
Old adults had greater variability of peak velocity during the knee extensor , but not during the elbow flexor fatiguing task.
Old adults had increased activity in the right posterior parietal region for forgotten words in the Gamma band.
Old adults show a decreased recovery performance compared to young ones after unexpected perturbations increasing the risk of falls.
Old age cognitive status was measured by using a validated telephone interview.
Old age does not represent a contraindication to the implementation of the E.R.A.S protocol in patients that underwent colorectal surgery.
Old age is associated with reduced mobility of the hand.
Old age is nowadays defined as very old and people are characterized by illness , degeneration and health costs.
Old age is per se a risk factor for its development.
Old age , longer recommended surveillance interval , not having had polypectomy at screening and negative colonoscopy were statistically significant predictors of non-adherence.
Old age , low serum prolactin levels , and extrasellar extension were associated with NFPAH.
Old age psychiatrists , aged psychiatry clinicians , behavior management teams and RACF staff completed the questionnaires.
" Old age symptomatic depression " was defined using the Composite International Diagnostic Interview @number@ tool.
Old age VMRs are significantly enriched for neurotransmission pathways.
Old age was significantly associated with a poor prognosis upon univariate analysis , while this association vanished upon multivariate analysis.
Old animals are rare in nature , but survival to old age has become commonplace in humans.
Old blood was defined as more than @number@ days old.
Old compared to young adults employed greater motor flexibility , stabilizing ground reaction forces during sit-to-sand.
Old dentin acid etched for @number@ s ( G15O ) had a lower μTBS than when acid etched for @number@ s ( G30O ) .
Older adult callers mainly requested non-emergency medical service responders during medium risk situations.
Older adult health is often defined in clinical terms.
Older adult participants ' respiration , pulse , and restlessness are monitored as they sleep.
Older adults ' ability to mitigate the effects of noise was further assessed with RT variability , as measured by intra-individual standard deviations across trials.
Older adults accumulate long time in SB.
Older adults adopted more cautious strategies , especially when the risk to commit an error was elevated.
Older adults also described the self as more similar to others and tended to describe the self more positively.
Older adults also did not benefit fully from using VTF in their first session.
Older adults also exhibited a lower required COF when walking at a controlled speed without controlling step length.
Older adults also had more connectivity between anterior and posterior regions than younger adults.
Older adults also reported fewer substance use disorders , more lifetime hospitalizations and higher social impairment.
Older adults also showed such an emotional DPE , but it was present with both upright and inverted faces.
Older adults also took significantly more medications than younger adults ( F ( @number@ ) = @number@ P < @number@ ) .
Older adults also typically suffer from health literacy challenges , which put them at increased risk of adverse health outcomes.
Older adults and DA were less accurate than younger adults when all to-be-learned relations were arbitrary.
Older adults ' appearance is often removed from cultural ideals and stereotypes of beauty , often seen as synonymous with \ "youth. \ "
Older adults are a heterogeneous group of individuals with varying physical capabilities , cognitive functioning and co-morbidities and life expectancies.
Older adults are a heterogeneous group , which may implicate that their use of the Internet is diverse as well.
Older adults are also predisposed to water retention and related electrolyte abnormalities , exacerbated at times of physiological stress.
Older adults are also socially resilient adapting to the loss of social ties by increasing involvement with community and kin networks.
Older adults are a special patient population who require attention to a variety of issues and considerations related to infusion therapy.
Older adults are at particular risk of the consequences of vitamin D deficiency owing to a combination of physiological and behavioural factors.
Older adults are capable of learning incidental , environmental information but their learning was not identical to younger adults'.
Older adults are discriminated against in employment , health care , and other domains.
Older adults are generally more comfortable responding to survey items when asked by a real person rather than by completing self-administered paper-and-pencil or online questionnaires.
Older adults are heterogeneous and often excluded from clinical trials , severely limiting generalizable data for this population.
Older adults are known to perform more poorly on measures of the functional field of view ( FFOV ) than younger adults.
Older adults are more susceptible than younger ones to chemotherapy toxicity , and may require dose modifications.
Older adults are not as good as younger adults at decoding prosodic emotions.
Older adults are particularly susceptible to severe and chronic infection.
Older adults are prescribed sedative-hypnotic medications at higher rates than younger adults.
Older adults attained significantly lower scores in both HS-SOT conditions than their younger peers.
Older adults benefitted by using emotional associative information to counteract memory burdens imposed by neutral associative information.
Older adults can achieve postural control using ankle joints in the self-timing task.
Older adults can safely perform muscle mechanography measurements.
Older adults can use context information in recognition memory at least as efficiently as younger adults when suitable materials and conditions are provided.
Older adults can use the Internet for different activities , and this usage can be of influence on benefits the Internet can have for them.
Older adults commonly report muscle fatigue , which may be associated with reduced walking ability.
Older adults ' community integration needs post-TBI from high quality studies were summarized.
Older adults completed a working memory test either under stereotype threat about age-related memory declines or not under such threat.
Older adults constitute the greatest percentage of cancer survivors in the country , with @percent@ being aged @number@ years and older.
Older adults continue to be sexually active in their later years.
Older adults demonstrated a decrease in the theta-band learning-predictive signals over medial frontal but not anterior frontal cortex.
Older adults demonstrated a specific difficulty in the flexible use of taxonomic relations.
Older adults demonstrated reduced offset compared to younger adults when tested on the volar forearm.
Older adults demonstrated similar levels of stability and variability as their younger counterparts , but at slower peak movement velocity and increased task duration.
Older adults demonstrated slightly reduced overall speech recognition and obtained less spatial release from masking , as compared to younger listeners.
Older adults ' difficulties with compressed speech may arise from problems broader than just speech rate alone.
Older adults display a pervasive problem interpreting prosodic cues , but further study is required to clarify the stage at which performance declines.
Older adults do not sleep as well as younger adults.
Older adults endorsed items not included on typical measures of social anxiety at high rates.
Older adults ( especially men ) endorsed cognitive compensation and interpersonal enjoyment and reported using collaboration more frequently than middle-aged adults.
Older adults , even with clinically normal hearing sensitivity , have auditory perceptual deficits relative to their younger counterparts.
Older adults , even with clinically normal hearing sensitivity , often report difficulty understanding speech in the presence of background noise.
Older adults executed the lateral step with slower forward-directed and lateral-directed velocity despite similar step widths.
Older adults exhibit altered activation of the agonist and antagonist muscles during goal-directed movements compared with young adults.
Older adults exhibit decreased performance and increased trial-to-trial variability on a range of cognitive tasks , including speech perception.
Older adults exhibit diminished ability to inhibit the processing of visual stimuli that are supposed to be ignored.
Older adults exhibited greater spatial and temporal errors and greater variability in finger acceleration and end position during both the lifting and lowering tasks.
Older adults exhibited greater variability in switching in the evening than in the morning , whereas younger adults showed the opposite pattern.
Older adults exhibited impaired memory performance compared with young adults , but also accurately estimated they forgot more information than young adults.
Older adults exhibited intact item memory and impaired associative memory relative to full attention younger adults.
Older adults exhibited lower posteromedial activity during encoding and higher frontal activity during retrieval , possibly reflecting greater involvement of control processes.
Older adults exhibit greater motor variability , which impairs their accuracy and function , compared with young adults.
Older adults exhibit increased gait variability that is associated with fall history and predicts future falls.
Older adults experience a selective associative memory deficit by demonstrating intact item memory relative to impaired associative memory when compared with younger adults.
Older adults experienced a faster decline in physical function for the overall performance measure ( β = @number@ p < @number@ ) .
Older adults experience deficits in working memory ( WM ) that are acutely exacerbated by the presence of distracting information.
Older adults experienced faster increases in abstinence than younger adults.
Older adults failed to show this early negativity but did produce the expected frontal positivity.
Older adults frequently have to make important decisions relating to personal , health and financial issues.
Older adults further underwent lumbar cerebrospinal fluid draw for the assessment of AD pathology and FLAIR imaging for the assessment of WMHs.
Older adults generated more words in the morning and younger adults more in the evening , corresponding with self-report peak TOD.
Older adults had a larger increase compared with younger adults , suggesting that greater attentional demands were required in older adults when using VTF information.
Older adults had greater agonist EMG activity with high-cognitive demand and women had greater coactivation than men ( P < @number@ ) .
Older adults had greater movement deviations and compensated for just @percent@ of the novel dynamics compared with @percent@ in young adults.
Older adults had particular difficulty with accuracy and confidence for rearranged pairs , relative to intact pairs.
Older adults have a disproportionally high rate of completed suicide as compared to the general population.
Older adults have altered perception of the relative timing between auditory and visual stimuli , even when stimuli are scaled to equate detectability.
Older adults have been reported to have a lower evaporative heat loss capacity than younger adults during exercise when full sweat evaporation is permitted.
Older adults have more difficulty than young adults to make corrective step adjustments while walking , especially under dual-tasking conditions.
Older adults have much to share with younger generations about behaviors that promote sustainable living , yet few sustainability efforts are intergenerational in nature.
Older adults have numerous comorbidites as well as cognitive and sensory impairments that may affect adherence.
Older adults have surprisingly high levels of well-being , which has been referred to as a paradox in the past.
Older adults have the highest risk of death by suicide in the United States.
Older adults have varied postural responses during induced and voluntary lateral stepping.
Older adults , however , did not show this effect of type of information.
Older adults , however , exhibited both PPA adaptation to places and weak FFA adaptation to faces.
Older adults , however , exhibit impoverished sleep-dependent motor memory consolidation.
Older adults , however , perform similar to younger adults in WM tasks with negative distractors at low WM load.
Older adults in both groups displayed wider timing windows , over which they identified AV asynchronous speech as being synchronous , than younger adults.
Older adults , in contrast , exhibited significant cross-modal enhancement only with the unaltered face.
Older adults , in contrast , showed a uniform memory bias for negative social information ; their memory performance was not modulated by their expectations.
Older adults in the low utilization category had the lowest probability of death.
Older adults in the map study condition had greater difficulty learning the route in the forward direction compared to younger adults.
Older adults ' knowledge of outdoor risk factors and their outdoor fall prevention practices have not been examined.
Older adults lacked sufficient hip extension ROM to walk with a hip extension angle as large as that of young adults.
Older adults living alone with dementia are at greater risk of placement in long-term care homes compared with those living with others.
Older adults living in Chicago's Chinatown had the lowest prevalence of perceived discrimination compared with those living in other areas.
Older adults living in deprived areas are at risk of developing frailty and becoming care dependent.
Older adults living with HIV ( OALWH ) comprise a growing population with a range of complex and interconnecting medical and psychosocial needs.
Older adults made more errors in all conditions.
Older adults maintained good performance accuracy at the expense of slower response times.
Older adults may be vulnerable to frontal plane dynamic instability , which is of clinical significance.
Older adults may encounter challenges in maintaining the connections they used to have or in forming new connections.
Older adults may have unrecognized airway obstruction due to functional limitations or symptoms mis-attributed to age / other co-morbidities.
Older adults may use a variety of identity maintenance processes to retain their positive sense of self.
Older adults ' memories of events that occurred in adolescence and early adulthood are over-represented compared to other lifetime periods.
Older adults ' memory reports are often less complete and accurate than those by younger adults.
Older adults ( n = @number@ ) were tested on two amounts of time compression and one low-pass filtering condition.
Older adults ( @number@ + years ) often have greater difficulty in reading than young adults ( 18-30 years ) .
Older adults often experience memory impairments , but sometimes they can use selective processing and schematic support to remember important information.
Older adults often find it more difficult than younger adults to attend to a target talker when there are other people talking.
Older adults often have nonspecific complaints , warranting a thorough health history and physical examination , including prescription and over-the-counter medications.
Older adults often perform poorly on Theory of Mind ( ToM ) tests that require understanding of others ' beliefs and intentions.
Older adults often require distinctive assessment , treatment and disposition.
Older adults often show different functional activation patterns than younger adults in prefrontal cortex ( PFC ) when performing cognitive control tasks.
Older adults often suffer from the frailty syndrome , partly due to diminished resilience.
Older adults often take numerous medications for multiple chronic conditions , so they have an increased risk for drugs that potentially cause falls.
Older adults , on the other hand , engaged two distinct networks for encoding of positive and negative targets.
Older adults , on the other hand , used the dissociation pattern regardless of the ID.
Older adults overwhelmingly adopted a hip strategy , but none adopted an ankle strategy.
Older adults overwhelmingly preferred an egocentric strategy , while younger adults were equally distributed between egocentric and allocentric preference.
Older adults , particularly those with chronic obstructive pulmonary disease , are advised to receive 23-valent pneumococcal polysaccharide vaccine ( PPV23 ) .
Older adults perceived increases in both gains and losses in CP in old age.
Older adults performed as well after training as did college-age younger adults prior to training.
Older adults performed as well as younger adults for discriminating motion away from vertical.
Older adults performed better and were more confident in their knowledge than were the other @number@ groups.
Older adults performed less well than younger adults on event memory tasks.
Older adults pose additional dilemmas in care.
Older adults provided oral life stories , and they divided their transcribed narratives into \ "chapters \ ".
Older adults rated events more positively than younger adults did , regardless of the memory source.
Older adults rated their ability to recognise faces as poorer compared to young adults.
Older adults recall less episodically rich autobiographical memories ( AM ) , however , the neural basis of this effect is not clear.
Older adults recognized fewer word stimuli than did younger adults , and context effects were larger for older adults.
Older adults regularly performing exercises during the 2-year study period were grouped into regular exercise group ; otherwise in the irregular exercise group.
Older adults reported less dispositional emotional empathy as assessed by the interpersonal reactivity index , and their unpleasantness ratings were more sensitive to intentional harm.
Older adults reported similar enjoyment across all groups.
Older adults reporting low anger expression had metabolic syndrome rates comparable to younger adults.
Older adults represent an extensive proportion of Type @number@ diabetic patients.
Older adults represent over @percent@ of most emergency department ( ED ) volumes.
Older adults required significantly more trials to learn the sequence than young adults ( p < @number@ ) .
Older adults require more attention for motor control while walking than younger adults.
Older adults seem to be particularly vulnerable to such effects.
Older adults seem to plan slower and shorter-ranged initial pulses towards the target , and rely more on sensory feedback to ensure endpoint accuracy.
Older adults select housing options that provide a range of services from minimal assistance to 24-hour skilled nursing care.
Older adults should be screened for fall risk annually.
Older adults show deficits in remembering associative information but can sometimes remember high-value information.
Older adults show disproportionate declines in explicit memory for associative relative to item information.
Older adults showed a shallower slope and poorer discrimination compared with younger adults , and both groups exhibited better performance with familiar than unfamiliar faces.
Older adults showed higher agreement with negative statements about ageing.
Older adults showed less adaptive strategy selection for the imagery strategy but not for the sentence strategy.
Older adults showed lower retention than middle-aged adults ( p < @number@ ) .
Older adults showed more PI-related errors than young adults in both tasks.
Older adults showed PEs for low-load lists.
Older adults showed significantly lower P1 amplitude and @percent@ of older adults showed a double peaked P1 compared to @percent@ of younger adults.
Older adults showed slower go responses but a comparable accuracy to younger controls.
Older adults showed smaller filtering scores than young adults , but only early in the retention interval , suggesting that efficient filtering was delayed.
Older adults showed smaller material-independent contextual binding effects in frontal regions , namely the left dorsolateral PFC , and larger binding effects in the hippocampus.
Older adults show hyper- ( or excessive ) binding effects for simultaneously and sequentially presented distraction.
Older adults significantly benefited from feedback provided by the experimenter on the tasks of intermediate difficulty.
Older adults spent less time planning and more time executing their conflicting responses , with the opposite pattern in younger adults.
Older adults ' substance use , service use , housing instability , and program retention were similar to their younger counterparts.
Older adults switched less frequently than younger adults and this effect was the same at each RSI.
Older adults ' task selection was unaffected by stimulus repetitions indicating that they were less flexible with the processing they used to guide task selection.
Older adults tend to require fewer energy content and higher levels of nutrients to promote and maintain optimal health.
Older adults , the most sedentary age group , are especially at risk due to their high levels of television viewing time.
Older adults typically experience greater levels of thermal strain during physical efforts in the heat compared to young individuals.
Older adults typically present with multiple pain etiologies , making it all the more imperative that a comprehensive assessment is conducted.
Older adults undergo anatomic and physiologic changes of the protective mechanisms of the pulmonary system.
Older adults under stereotype threat had lower intrusion rates during free-recall tests ( Experiments @number@ and @number@ ) .
Older adults universally suffer from sarcopenia and approximately 60-70% are diabetic or prediabetic.
Older adults used their metacognitive knowledge to make source guesses but showed a deficit in varying their source guessing based on word recognition.
Older adults use lower developmental movement patterns that may be a \ "normal \ " adaptation to age-related sensorimotor changes.
Older adults using physician-recommended sleep medications exhibited a consistently higher fall risk irrespective of the extent of insomnia symptoms.
Older adults were also more stable than younger adults at all step targets ( p < 0.001 ) .
Older adults were better at matching their strategies to their goals than young adults were.
Older adults were divided into low and high falls-risk groups based on Physiological Profile Assessment scores of sensorimotor function.
Older adults were divided into non-frail and frail groups ( Reference intervals and decision limits are a critical part of the clinical laboratory report.
Older adults were found to have significantly smaller C-ABRs with longer latencies , despite all latencies falling within normal limits.
Older adults were found to significantly slow down their downward and forward COM motions in UR but not young adults.
Older adults were interested in preserving their health and independence , but some had difficulty staying motivated to maintain a healthy lifestyle.
Older adults were just as able as young adults to use item familiarity to recognize which word of a foil was old.
Older adults were less accurate than young adults with both object classes , while face matching was notably impaired.
Older adults were more likely than young adults to choose deferral.
Older adults were more likely than young adults to falsely recognize novel conjunctions of familiar actors and actions.
Older adults were more likely to endorse chronic emptiness , and less likely to endorse impulsivity , self-harm , and affective instability.
Older adults were slower at making literality judgments and more sensitive to conflicts between literal and figurative meanings.
Older adults were studied again following n3-PUFA supplementation ( @number@.9g / day , @number@ weeks ) .
Older adults who exercise may be able to retain olfactory function with age.
Older adults who had more friends were less likely to report marital conflict ( OR = @number@ CI = @number@.43-0.86 ) .
Older adults who have lived in the U.S. longer had a higher risk of financial exploitation ( OR @number@ [ @number@ @number@ ] ) .
Older adults who learned the route by self-navigation were less accurate in traversing the route in the reverse compared to forward direction after a delay.
Older adults who lived with a family member had more severe mood symptoms and poorer mental health functioning.
Older adults who live in residential neighborhoods adjacent to college and university campuses have a unique experience that makes them vulnerable to marginalization and displacement.
Older adults who remained active or increased activity over time had a reduced risk of cognitive decline.
Older adults who used deferral reported less retrospective negative emotion than those who did not.
Older adults who visit emergency departments ( EDs ) often experience delirium , but it is infrequently recognized.
Older adults who were women , current smokers , or who had a low PEF were less likely to receive the PPV23.
Older adults will derive distinct benefits from aerobic exercise , strength or resistance training , flexibility or stretching exercises , and balance training.
Older adults with a diagnosis of SA had higher average number of comorbidities than those without SA ( @number@ vs @number@ ) .
Older adults with a sleep duration < 6 h were more prone to obesity ( OR : @number@ @percent@ CI : @number@ @date@ ) .
Older adults with CLBP walked slower than their pain-free peers during self-selected and fast walking.
Older adults with cognitive decline have reduced functional independence and quality of life , and are at greater risk for developing dementia.
Older adults with current sleep disturbances will be recruited from the urban Los Angeles community.
Older adults with dementia are prescribed multiple medications , both to treat dementia symptoms and to manage their other medical conditions.
Older adults with Diabetes Mellitus ( DM ) experience greater risk for comorbid depression compared to those who do not have DM.
Older adults with diabetes residing in the long-term facilities represent the most vulnerable of this cohort.
Older adults with elevated Aβ were characterized by decreased activity in left fusiform compared to Aβ-negative older adults.
Older adults with gait deficits have an increased risk of developing cognitive deficits and cognitive deficits are associated with worsened gait.
Older adults with gait deficits have an increased risk of developing cognitive deficits , even dementia.
Older adults with gait impairment have an increased risk of developing cognitive impairments.
Older adults with heart failure often have preserved ejection fraction and atypical and delayed clinical manifestations.
Older adults with higher stress severity demonstrated a significantly higher cortisol : DHEA ratio.
Older adults with HIV , who sill comprise @percent@ of the US HIV-infected population by @number@ are disadvantaged as evidenced by disproportionately poorer health outcomes.
Older adults with ID often present with medical co-morbidities and mental health issues.
Older adults with Intellectual Disabilities form a small , but significant and growing proportion of older people in the community.
Older adults with intellectual disabilities ( ID ) show more signs of early frailty than the general population.
Older adults with MCI and AD differ in terms of reported fear of falling and falls self-efficacy.
Older adults with MCI had significantly higher frequency of being at risk of malnutrition or malnourished than those with normal cognition.
Older adults with medium- and high levels of CRF were more physically active , compared to those with the lowest levels of CRF.
Older adults with metabolic syndrome , especially those with high blood pressure and hyperglycemia , may benefit from evaluation for subclinical atherosclerosis.
Older adults with serious mental illness ( SMI ) are an understudied population with complex care needs and high rates of obesity / overweight.
Older adults with significant anxiety or depressive symptoms were offered short-term psychotherapy.
Older adult women were found to have less social support and social participation compared with men.
Older AEDs like phenobarbitone and phenytoin should be avoided in the elderly because of their pharmacological profiles.
Older age and decreased activity were the risk factors in this study.
Older age and diabetes mellitus ( DM ) are among the major risk factors for PAD , and both are associated with increased arterial stiffness.
Older age and female gender were associated with thinner MT.
Older age and greater initial thickness were associated with a smaller increase in dermal thickness according to multivariate analysis.
Older age and lower admission GCS were additionally associated with overall poor prognosis.
Older age , comorbidity , lower MMSE score , lower ADL and IADL scores increased the risk of mortality in the study group.
Older age , diabetes mellitus , lower serum cholesterol and lower serum triglyceride were independent risk factors for mortality.
Older age groups had higher complication rates , and older age and complications were independently associated with 1-year mortality ( P < 0.0001 ) .
Older age is associated with lower mean of HRV.
Older age , lower hemoglobin , and lower CD4 counts were the VACS components most strongly linked to NCI.
Older age , male gender , smoking , increased dependency and tissue inflammation were associated with lower vitamin C concentrations.
Older age ( ≥ @number@ ) was associated with increased PGE-M.
Older age , obesity , family history , and current protease inhibitor use were consistently associated with comorbidity.
Older age per se is not necessarily associated with a decline in practice-dependent functional plasticity and adaptation.
Older age ( P = @number@ ) and possibly total body irradiation-based conditioning ( P = @number@ ) were risk factors for developing ES.
Older age produces numerous changes in cognitive processes , including slowing in the rate of mental processing speed.
Older age , vocational education and unemployment were associated with regular smoking initiation among men and women.
Older age was also associated with greater proportions of CD28-CD8 + T cells expressing CD57 ( rho : @number@ P = 0.007 ) .
Older age was associated with a decreased expression of the majority of the SIRT genes.
Older age was associated with a higher level of PTS symptoms.
Older age was associated with a lower degree of fiber alignment and larger matrix stiffness for both diabetic and non-diabetic scleras.
Older age was associated with decreased odds of high anticholinergic burden.
Older age was associated with greater risk for developing a CMB ( odds ratio @number@ ) .
Older age was associated with worse lung function ( OR @number@ and @percent@ CI @number@.1-3.3 ) .
Older age was the only statistically significant risk factor for steeper cognitive decline , which may have important clinical consequences for patient management and education.
Older and younger adults listened to melodies that had expected or unexpected ending notes , according to Western music theory.
Older and younger adults performed similarly on the PM task.
Older and younger adults were compared.
Older and younger cocaine abusers used similar amounts of cocaine ( p > @number@ ) .
Older and younger drivers were compared with respect to the presence of factors related to intersection crashes using a multivariate Poisson regression model.
Older and younger healthy groups did not differ from each other on these tests.
Older and younger learners chose the same types of items for restudy , but the effectiveness of these choices differed greatly by age.
Older and younger readers read sentences in which target words were masked @number@ to @number@ ms after fixation onset.
Older as compared with younger adults showed fixation patterns away from negative image content , while they reacted with greater negative emotions.
Older asthmatics have an increased likelihood of comorbidities and polypharmacy , with possible worsening of asthma control and reduced treatment adherence.
Older athletes will approach clinical cardiologists for advice regarding their fitness for participation.
Older Black adults with HIV may be at particular risk of loneliness due to stigma and lack of social resources.
Older , but not younger , adults decreased central pressure during inflammation ( p < @number@ ) .
Older cancer patients have the unique perspective of looking back on a long life and looking forward to impending death.
Older cancer patients need to cope with two major stressful situations simultaneously - age-related stress and illness-related stress.
Older cancer patients tended to use an avoiding coping strategy more frequently than middle-aged cancer patients.
Older cells accumulate in both experimental rat infection and in human cryptococcosis.
Older C. glabrata cells accumulate during murine and human infection , which is statistically unlikely without very strong selection.
Older characters were disproportionately featured in major roles , depicted as employed and open to new experience.
Older characters were kept at a greater camera distance than younger characters in \ "young commercials. \ "
Older children are more successful at producing unfamiliar , non-native speech sounds than younger children during the initial stages of learning.
Older children employed a hybrid strategy , exhibiting slower movements in bimanual congruent conditions , but larger non-dominant apertures in bimanual incongruent conditions.
Older children produced more conditioned eyeblink responses than younger children and adults produced more than children.
Older children showed a greater tendency to telescope earlier memories and a weaker tendency to reverse telescope later memories than did younger children.
Older children were better on fact recall , but both ages were comparable on source recall.
Older Chinese people are facing diverse choices of long-term care ( LTC ) modes.
Older cocaine abusers also performed more poorly than younger cocaine abusers on TMT A ( p < @number@ ) .
Older cocaine abusers performed more poorly than older control participants and younger cocaine abusers on the Digit Span Forward ( p < @number@ ) .
Older drivers are at greatest risk for injury or death as a result of a car crash.
Older ED attenders are also more likely to require investigations , procedures and hospital admissions.
Older , especially minority , men suffer high rates of depression under-treatment.
Older executives scored higher on verbal ability , a measure most often associated with crystallized intelligence.
Older fallers with complete delirium risk assessments prior to falling were identified.
Older female patients and those with multiple comorbidities and medications appear to be at the highest risk of an ADR in the acute care setting.
Older females were particularly more likely to pay attention to suicide in the media.
Older healthy subjects had preserved hypoxic cardiorespiratory and tissue oxygenation responses at rest and during moderate exercise.
Older hemophilia patients also now face the same medical conditions associated with aging in the general population , including cardiovascular disease and cancer.
Older HIV-1 + individuals had a greater number of hypermethylated CpGs across ME3 ( p = 0.015 ) .
Older HSCT recipients experience significantly increased morbidity and mortality compared to young recipients.
Older humans in the No Reminder condition made significantly more intrusions than those in the Reminder condition.
Older inactive underweight , normal weight , and overweight adults have lower odds of high HRQL.
Older individuals ( aged ≥75 years ) were less likely to initiate PIMs.
Older individuals also undergo nonuniform gray matter volume ( GMv ) loss.
Older individuals are at increased risk for poor outcomes in complicated PUD and for development of GERD complications.
Older individuals are more susceptible to most acquired liver disorders and more vulnerable to the consequences of liver disease.
Older individuals are usually more cautious , walk more slowly , take shorter steps , and exhibit increased step-to-step variability.
Older individuals display a blunted muscle protein synthetic response to dietary protein ingestion.
Older individuals experience greater increases in YEM than do younger adults , even after considering the effects of traditional risk factors.
Older individuals often experience declines in cognitive function after events ( e.g. infection , or injury ) that trigger activation of the immune system.
Older individuals seem to be characterized by blunted physiological reactivity , suggestive of impaired adaptive responses to acute stressors.
Older individuals show decline of prefrontal cortex ( PFC ) functions which may be related to altered dopaminergic neurotransmission.
Older individuals showed significantly less stiffness modification between the two perturbation conditions compared to the younger individuals , indicating less optimal modulation of arm impedance.
Older individuals were more glucose intolerant , which was explained by a decrease of insulin secretion more than adiposity-related IR.
Older individuals with diminished motor and physical functionality suffer a heightened risk of social exclusion and loneliness.
Older LGBT adults are @number@ times less likely to access health care and social services ( King , @number@ ) .
Older listeners had slower RTs than younger listeners , but this difference was smaller in congruent than in neutral or incongruent conditions.
Older males displayed smaller gross trunk range of motion from standing to maximum flexion than any other group.
Older men and women have similar rates of hospital admissions and visits to emergency departments and physician offices.
Older men and women tended to use appointment-based clinics more regularly than those who were younger.
Older men , on the other hand , have a large pool of potential dating partners and do not face the same dilemma.
Older mice had an enrichment of a trithorax group ( TrxG ) protein complex at the Ink4a locus.
Older mice had hypertrophied classic brown adipocytes that had larger cytoplasmic lipid droplets than younger mice.
Older musicians also showed a closer correspondence between neural activity and perceptual performance.
Older negative learners showed a stronger tendency to avoid negative outcomes than younger negative learners.
Older ( @number@ years old and above ) cancer patients receiving treatment were recruited.
Older obese individuals who lose weight should receive thoughtful medical attention.
Older observers were less sensitive for all check sizes , but the relative sensitivity across sizes , also differed between groups.
Older participants , Blacks , the less educated and those with lower income were higher on both edentulism and number missing teeth.
Older participants demonstrated greater multisensory integration a greater influence of the beeps when judging the number of visual flashes than younger observers.
Older participants did not discriminate appropriate and inappropriate behaviors as well as young participants.
Older participants in the present study showed poorer intelligibility of degraded speech than the younger group , as expected from previous reports of aging effects.
Older participants ' latencies were slower , especially in the presence of distractors , and their calculated capacity indicators increased with distractors.
Older participants reported longer MT than young participants when executing arm movements , but not when imagining them.
Older participants responded more slowly than younger participants.
Older participants showed quantitative differences to their younger counterparts - movements were slower and peak speed did not scale with object distance.
Older participants showed the maximal change in SEC patterns between resting state and the SA task.
Older participants were also more confident in their judgements of own-age , relative to other-age , speakers.
Older participants were more likely to report lower levels of perceived isolation.
Older participants were remarkably accurate in performing arithmetical tasks although their numerosity discrimination ( also known as ' number acuity' ) was impaired.
Older participants were significantly more likely to have lower ( worse ) ODT scores than younger participants ( P < @number@ ) .
Older participants whose health varied from poor to very good reviewed written material prior to making decisions about health related and non-health-related issues.
Older participants , women , and Whites were more likely to complete their examinations.
Older patients above @number@ years of age also displayed significantly higher HRQOL ( @number@ points ) .
Older patients aged ≥ @number@ years were analysed.
Older patients also exhibit a less robust humoral response , with the production of less avid and specific antibodies.
Older patients and women attained lower final functional ability than younger patients and men , but improved similarly.
Older patients had a male predominance ( male / female ratio , @number@.9 : 1 ) .
Older patients had less generalized motor seizures , but the differences between groups did not reach significance ( P = 0.01 ) .
Older patients have a different stroke risk profile and different stroke features compared with younger patients.
Older patients have a higher mortality and a greater deterioration of walking ability after such injuries.
Older patients have an higher allele burden.
Older patients have an increased risk of these AEs and are more likely to take multiple medications that can potentially interact with NSAIDs.
Older patients have more co-morbidity , therefore the toxic effects of chemotherapy treatment are less tolerable compared to younger patients.
Older patients may experience more symptom burden with swallowing , voice / speech , and nutrition.
Older patients may prove a diagnostic challenge due to co-morbidities.
Older patients ( ≥ @number@ ) with fracture risk factors treated with LIPUS exhibit similar heal rates to the population as a whole.
Older patients opting for no treatment may have worsening function including decreased sleep , mobility , socialization , and increased depression.
Older patients should not be refused Transition Care based on the presence of cognitive impairment.
Older patients who had internal fixation of intracapsular fractures had a better walking ability at @number@ months.
Older patients with acute kidney injury ( AKI ) comprise an increasing proportion of patients with CKD / ESRD as well.
Older patients with bipolar disorder had a greater functional impairment than the healthy control group.
Older patients with cancer will increasingly be taken care of by informal family caregivers.
Older patients with diabetes have a high risk of vascular complications.
Older patients with haemophilia ( PWH ) face many challenges related not only to haemophilia but also to general comorbidities associated with ageing.
Older patients with hemophilia face many challenges related not only to hemophilia but also to general comorbidity associated with aging.
Older patients with ischemic stroke , and , among patients with ischemic stroke and subarachnoid hemorrhage , women , incurred higher costs.
Older patients with type @number@ diabetes are at risk of HHS in the course of sepsis or in the perioperative period.
Older patients with type @number@ diabetes like patients with renal insufficiency an important and populous subgroup also have issues with therapy selection and dosing regimens.
Older people admitted to hospital are a potential target population for screening for dementia.
Older people also are at a higher risk of developing ESRD.
Older people and those with a lower education level are most at risk for the MetS.
Older people are at an increased risk of nail alterations , including normal age-related changes and disorders that more commonly affect this specific population.
Older people are particularly exposed to stressful events , known to activate the axis resulting in increased cortisol levels.
Older people are taking many medicinal products daily and these may not necessarily be suitable for them.
Older people are vulnerable to losses in physical function capacity , and such losses predict loss of independence , falls , and even mortality.
Older people coming to the emergency department have three to seven times higher rates of hospitalization than younger people.
Older people experience enhanced susceptibility to viral infections and subsequent superimposed bacterial infections.
Older people face chronic conditions such as sarcopenia and functional decline , which are often associated with disability and frailty.
Older people have higher SNA and higher BP.
Older people have justifiably been highlighted as a high-risk group with respect to heat wave mortality and morbidity.
Older people have lower rates of protein synthesis and whole-body proteolysis in response to an anabolic stimulus ( food or resistance exercise ) .
Older people have more health issues and use more healthcare services than young people.
Older people increase their well-being and contribute to the community when they volunteer.
Older people may be less likely to recall childhood abuse.
Older people need to make up for age-related changes in protein metabolism , such as high splanchnic extraction and declining anabolic responses to ingested protein.
Older people often exhibit memory impairments.
Older people often forget tasks and appointments , and decreased mobility can limit their social interaction.
Older people , particularly those who are economically vulnerable , are among those most at risk in disasters , including events resulting from climate change.
Older people perceived themselves to be anemic because of symptoms and beliefs about causes.
Older people reaching end-of-life status are particularly at risk from inter-related adverse effects of pharmacotherapy , including polypharmacy , inappropriate medications and adverse drug events.
Older people reaching end-of-life status are particularly at risk of adverse effects of drug therapy.
Older people's assessment and management in the ED can be complex , time consuming , and require specialist skills.
Older people sit at the centre of a unique constellation of factors that combine to increase their vulnerability to the negative effects of catastrophic events.
Older people sometimes show a bias toward the processing of positive information.
Older people were less likely to mention future-oriented thoughts of eventual success associated with greater willingness to continue the failing plan.
Older people with asthma are a discrete patient group that requires specialist nursing skills and knowledge.
Older people with diabetes should be monitored for cognitive problems and brain lesions.
Older people with sarcopenia had higher chance of reduced mobility ( OR : @number@ 95%CI : @date@ @number@ ) .
Older persons are at risk for impaired cerebral autoregulation ; lowering their BP may compromise cerebral blood flow and cognitive function.
Older persons follow the same profile of under-reporting as younger adults.
Older persons have a decrease in efficiency of mental faculties and change in mechanisms of perception functions.
Older persons , in general , live in large , complex , and multigenerational households.
Older persons targeted by AAL technologies especially need more easy-to-use methods to interact with inherently complex supporting technology.
Older persons with cardiac or cognitive signs and symptoms may have both cardiac and cerebral diseases and should be evaluated accordingly.
Older persons with more than one health insurance spent less on out-of-pocket health care costs.
Older persons with possible dementia were also removed.
Older persons with type @number@ diabetes are at increased risk of falling compared to healthy adults of a similar age.
Older PF , but not DF muscles , were stiffer compared to young.
Older prisoners are the fastest growing group of prisoners in many countries.
Older readers showed differential contextual sensitivity in regression patterns , effects not moderated by literacy skill.
Older residents ( ≥65 years old ) taking at least one prescribed medication were included.
Older respondents are more satisfied with their living situation and less likely to move.
Older respondents as well as respondents who identified themselves as Caucasians tended to buy organic chicken more frequently.
Older rodents appear to be particularly vulnerable to the motor- and cognitive-impairing effects of acute alcohol relative to younger adults.
Older Romanians are expected to make up more than @percent@ of the total population by @number@
Older runners also exhibited increased knee abduction impulse , ankle abduction impulse and vertical loading rates.
Older runners had smaller ankle plantarflexion moment ( P = @number@ ) and hip rotational moment ( P = @number@ ) than younger runners.
Older Singaporean men tended to sleep for shorter duration , but exercised more intensely than younger men.
Older smokers identified as having ND were first diagnosed at a relatively older age.
Older studies examining acute urea infusion suggested that urea was well-tolerated at levels 8-10× above normal values.
Older subjects again exhibited an increased inversion effect.
Older subjects also showed a trend towards more forward leaning of the trunk , resulting in increased hip flexion and anterior thoracic tilt.
Older subjects also showed longer SW positive and negative phase durations.
Older subjects also showed poorer performance for large spatial displacements across a wide range of ISIs.
Older subjects generally had fewer years of education , which was related to a lower openness score.
Older subjects had higher carotid-femoral PWV than younger subjects.
Older subjects had impairment in LV relaxation.
Older subjects increased peak forearm blood flow while young subjects showed no change.
Older subjects reached the maximal values for this EEG parameter during the less WM demanding 0-back task.
Older subjects required significantly more time to perform a deep squat , especially during the descending phase.
Older subjects showed evidence of slower learning than younger subjects.
Older subjects showed lower SW density and amplitude than young subjects.
Older subjects were slower in descend than ascend during the squat.
Older versus younger patients had more comorbidities.
Older veterans had more general medical problems and approximately $ 500 more in program costs.
Older volunteers activated dorsolateral PFC regions bilaterally while young subjects recruited these areas only in the left hemisphere.
Older widowers are more likely to remarry than older widowed women.
Older women ( age 50 + ) living with HIV ( OWLH ) are often an under-recognized aging group.
Older women better scored for meat , dairy , cholesterol and dietary variety.
Older women cope by trying to make sense of their lives and nurturing themselves in small ways.
Older women in the arthritis group appeared to be the least active across physical activities and groups.
Older women in the low-income group had less controlled BP than those women in the high-income group.
Older women remain subtly responsive to nutrition ± exercise.
Older women reported less concern over the impact of cancer on finances ( P = @number@ ) .
Older women were examined to determine the associations among BMI , AFI and cardiometabolic variables.
Older workers ( 60-64 years ) reported better scores on social functioning , mental health and vitality compared with workers aged 45-59 years.
Older workers completed four standardized tests reflecting the job design and successful aging variables.
Old individuals maintain the ability to adapt to feedback controlled perturbations.
Old individuals showed higher IMCL content in the subsarcolemmal area.
Old lesbians of African descent have experienced racism , heterosexism , homophobia , and ageism.
Old men had larger IMCL droplets than all other groups in the total muscle area.
Old MII mothers carry the shortest ( p˂0.001 ) , control mothers have the longest telomere and MI lies in between.
Old monkeys have dramatically reduced intestinal motility , and all changes in motility and MT are present without large differences in fecal microbiomes.
Old-old adults ' PM accuracy was reduced relative to both young-old and younger adults.
Old participants were deleteriously affected by reduced temporal sampling particularly at low contrasts.
\ "Old persons \ " were evaluated differently in the various life domains , and age thresholds for ascriptions of being old differed between domains.
Old rats displayed significant deficits in spatial memory.
Olfaction represents an ancient , evolutionarily critical physiologic system.
Olfaction was measured as odor identification ( OI ) with the 12-item Cross Cultural Smell Identification Test in year @number@
Olfactory ability was measured using the University of Pennsylvania Smell Identification Test ( UPSIT ) .
Olfactory assessment may have potential as a screening tool to detect age-accelerated neurodegeneration in the elderly.
Olfactory dysfunction can be an early sign of Alzheimer's disease.
Olfactory dysfunction in carriers does not appear to be allele specific , but is strongly age-dependent and precedes symptomatic onset.
Olfactory dysfunction may precede common neurodegenerative disorders in the elderly , such as Alzheimer ( AD ) or Parkinson disease ( PD ) .
Olfactory dysfunction was , however , not related to phantosmia.
Olfactory functioning was not strongly or consistently associated with decision making over and above general cognition.
Olfactory function was assessed by Sniffin ' Sticks Extended Test ( Burghart , Medizintechnik , GmbH , Wedel , Germany ) .
Olfactory hallucinations occurs in approximately half of patients with TEA , but do not always coincide with reduced sense of smell.
Olfactory identification performance was established in AD patients , and young and elderly healthy subjects using the Pocket Smell Test.
Olfactory identification was most proficient in the healthy participants and least proficient in AD , although this disparity did not depend on nostril side.
Olfactory impairment and interictal memory problems both occur frequently in TEA but are not closely associated.
Olfactory impairment , a well-known biomarker for neurodegeneration , might be present in the condition early , possibly representing a signal for future pathological onset.
Olfactory impairment is proportional to cognitive impairment in aMCI but not in naMCI.
Olfactory memory did not differ significantly across the groups , perhaps reflecting a floor effect.
Olfactory sensation modulates the TGF-β and insulin signaling pathways to control this developmental decision.
Olfactory sensitivity has been assessed by «Sniffin ' Sticks».
Olfactory tests should be specifically adapted to assess olfactory disorders in Alzheimer's disease patients.
Olfactory training is suggested to be an emerging modality in patients with postinfectious olfactory loss.
Olga began training for competitions at age of @number@ and as of @date@ held over @number@ world records in her age category in track-and-field.
Olga's FA in many normal-appearing WM regions , however , did not differ or was greater than in the reference sample.
Oligogenic inheritance implies a role for several genetic factors in disease etiology.
OLS results showed that respondents who completed primary school obtained @number@ percent higher scores on cognitive tests than those who did not.
Olympians ' observed and expected survivals were illustrated by Kaplan-Meier curves.
Omar Khayyam ( @number@ ) .
Omega-3 and omega-6 fatty acids are precursors of bioactive lipid mediators posited to modulate both physical pain and psychological distress.
Omega-3 fatty acids are now generally recognized as potential key nutrients to prevent the pathological conditions associated to the aging process.
Omega-3 ( n-3 ) fatty acids stimulate protein anabolism in animals and might therefore be useful for the treatment of sarcopenia.
Omega-3 ( n-3 ) polyunsaturated fattty acids ( PUFAs ) have anti-inflammatory activity that is not mediated through direct ROS inhibition.
Omega-3 polyunsaturated fatty acids ( n3-PUFA ) are recognized for their anti-inflammatory effects and may be beneficial in the context of sarcopenia.
Omega-6 and omega-3 FA are not interconvertible in the human body and are important components of practically all cell membranes.
Omental preadipocytes induced chemoattraction of macrophages and monocytes.
Omentectomy appears useful in children undergoing peritoneal dialysis catheter placement.
Omeprazole topically applied to the skin of UV-irradiated human subjects significantly reduced pigment levels after @number@ weeks compared with untreated controls.
Omeprazole treatment increased the proportion of EndoH sensitive tyrosinase , indicating that tyrosinase maturation was impaired.
OMS were delivered by a single practitioner.
OMT was defined as prescription of β-blocker and either angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in eligible patients.
On a 5-year time horizon , the Web-based intervention was preferred over the printed intervention.
Onabotulinumtoxin A ( Botox ) can be a safe and successful off-label treatment of vertical platysma bands of various severities.
OnabotulinumtoxinA had significantly more diffusion than abobotulinumtoxinA when isovolumetric injections of the same labeled unit dose of the products were injected.
OnabotulinumtoxinA was used in @percent@ of the studies , abobotulinumtoxinA in @percent@ , and incobotulinumtoxinA in @percent@.
On adjusted analysis , testosterone replacement therapy was not associated with overall or cancer-specific mortality or with the use of salvage hormone therapy.
On admission , each subject underwent standardized evaluation of cognitive and comorbid conditions.
On admission , her heart rate was @number@ beats / min with regular rhythm.
On a later recognition test , participants were asked to associate each previously told fact with the face to whom it was told.
On all locations , CVCmax decreased with age but less markedly in the forehead compared to the two other locations.
On a molecular level , it was further confirmed that CSE-treated mice had lower MMP-1 levels and higher procollagen type I levels than untreated mice.
On a molecular level , RecQL helicases and PARP1 are involved in the control of DNA repair , telomere maintenance , and replicative stress.
On a screen they were shown a black-shaped disk moving in one of three different directions associated with positive , negative and neutral valences.
On a separate day , an isoglycaemic intravenous glucose infusion was performed matching the individual glucose concentrations obtained during the oral glucose tolerance test.
On a separate occasion , participants completed a @number@ d estimated food diary.
On average , African Americans ( AfAm ) have longer LTL than whites , but the LTL-CHD relationship in AfAm is unknown.
On average , aging nurse faculty members are over @number@ years of age and face key retirement decisions over the next decade.
On average , almost twice as much fat was used ( @number@ ml versus @number@ ml in non-massive weight loss patients ) .
On average , current smokers had @number@ base pairs ( BP ) shorter LTL compared to never smokers.
On average , each AML genome contains approximately @number@ mutations , including 6-26 coding mutations.
On average , each individual carried one heteroplasmy , and one in eight individuals carried a disease-associated heteroplasmy , with minor allele frequency ≥1%.
On average , elderly NH residents visited EDs at a rate of @number@ visits per @number@ institutionalized persons.
On average , epigenetic age increased by @number@ y for each @number@ BMI units.
On average , expression levels of @percent@ of genes within these pathways are associated with age.
On average , four samples per subject were collected for up to @number@ days ( mean : @number@ days ) .
On average , frail respondents reported worse self-rated health and had fewer years of education.
On average , JNDs were @percent@ of the inter-onset interval and by and large were not affected by synchronization tapping.
On average , males had larger distances than females.
On average , neuroticism increased , whereas extraversion , conscientiousness , and perceived control significantly decreased over time.
On average , @number@ million single nucleotide polymorphisms were generated per study.
On average , @number@ % of the ECtHR case load included rulings that concern older persons ' rights.
On average , @number@ years had elapsed since the rape had occurred.
On average , @number@ yr earlier ( during midlife ) , demographic , socioeconomic , lifestyle , and biomedical factors were collected.
On average , older adults are less accurate than younger adults at recognizing emotions from faces or voices.
On average , participants showed significant reductions in TUG test scores at the postintervention ( @percent@ reduction , p < @number@ ) .
On average , patients with chronic pain were aged @number@ years and had a mean number of @number@ diagnoses.
On average , @percent@ of participants in both groups lost at least one tooth each year.
On average residents spent @number@ ( @date@ @number@ ) hrs / d undertaking sedentary activity.
On average , spines were posteriorly stabilized over @number@ segments.
On average , subjects presented a mean of @number@ ± @number@ health problems with diseases of the circulatory system being the most common.
On average , the e-liquid NNR increased from @number@ at @number@ days after opening to @number@ after @number@ days.
On average , the lips were thicker in men and in young persons than in women and in old persons.
On average , then , both groups appeared to show ability-specific effects.
On average , the platysma muscle occupied @percent@ of the malar mandibular line.
On average , the seasonal variation was larger than the longitudinal change.
On average , these patients report @number@ unrelieved and co-occurring symptoms.
On average , the total direct medical cost of one hospitalized and invasively-treated PAD case ranged from $ US @number@ to $ US @number@
On average , they report three chronic conditions.
On average , walnut supplement consumption was @number@ g / d or 1171·5 kJ ( @number@ kcal ) .
On average , women now live one-third of their lives after menopause.
On average , women reported experiencing more shame and guilt ; Blacks reported experiencing less shame and Asians more hubristic pride than other ethnicities.
On AW , movement artifacts made signals difficult to interpret.
On balance , there is a strong case for managing the health issues of adolescents and young adults together.
On base line survey , both guoups were followed up two years after vaccination about incidence , hospitalization rate , treatment and direct medical cost.
On biopsy there was no evidence for malignancy.
On both bivariate and multivariate analysis , the grade of both the SLIL and LTIL increased with age , but decreased with female gender.
Once a backwater in medical sciences , aging research has emerged and now threatens to take the forefront.
Once activated , AMPK inhibited 4E-BP1 signaling and mRNA translation via mammalian target of rapamycin ( mTOR ) .
Once a DHA residue was generated , it could form intermolecular cross-links with Lys and Cys.
Once an individual becomes a caregiver , the clinical experience of dementia caregiving is similar across caregiver types.
Once a pharmacological intervention has been proposed , efficacy must be demonstrated in this complex multi-morbid population.
Once a resting blood pressure has been obtained , pressure waveforms are acquired from the right femoral and right common carotid arteries.
Once at a critically short threshold , telomeres signal growth arrest , leading to senescence.
Once bound , IgG triggers the removal of the senescent cells by macrophages.
Once cells senesce , they are strongly resistant to any mitogens , including oncogenic stimuli.
Once cleaved , p75NTRICD recruits two intracellular interactors , NRIF and TRAF6 , which allows NRIF phosphorylation by JNK.
Once delivered to membrane sites , they naturally replace and stimulate removal of damaged membrane lipids.
Once developed , knowledge sharing through accessing , adapting , and applying the information was possible.
Once disturbed gonadal hormone function became the most likely explanation , it provoked other questions.
Once epithelialization was achieved , antipigment and sun protection agents were recommended.
Once identified , oxidatively modified proteins can be placed in specific molecular pathways to provide insights into protein oxidation and human disease.
Once in the brain , both free virus and virus-infected cells are able to infect neighboring resident microglia and astrocytes and possibly other cell types.
Once in the nucleus , MGRN1 potentiates the transcriptional cellular response to proteotoxic stress.
Once localized to membranes , LRRK2 then influences downstream events , evidenced by changes in the autophagy-lysosome pathway.
Once mental health services were accessed , no differences in mental health expenditures were found.
Once released into the circulation , irisin acts on white adipocytes to induce the browning response and subsequently activates nonshivering thermogenesis.
Once spotted , social isolation can be averted with the intervention of a multidisciplinary team.
Once symptomatic the morbidity from CSDH is not insignificant.
Once telomeres reach a critical length , DNA defense mechanisms can direct cells to either a state of arrest ( senescence ) or apoptosis.
Once that peak was crossed , complexity values slowly decreased until late senescence.
Once the adjustments of therapy are completed , lifelong follow-up with IOP-dependent conversion to glaucoma and progression to blindness are modelled.
Once the anatomy was defined on histology the dimensions and volume of the substantia nigra were determined on high field magnetic resonance images.
Once the balance is broken , age-related diseases could take place.
Once the inflammation is triggered , there is a self-perpetuating cascade of inflammation and lung parenchymal damage.
Once the patriarchal figure disappears , the female characters regain visibility by entering the labor market and starting relationships with other men.
Once they are critically short , telomeres become dysfunctional and consequently activate a proliferative arrest called replicative senescence.
Once thought to be only important for allergy-mediated events , mast cells are now recognized to be important regulators of a number of pathological processes.
Once validated , it may enable the advancement and evolution of conceptual and theoretical aspects of multimorbidity that will eventually lead to better care.
Once validated , such a questionnaire would assist in evaluating potential analgesic treatments for these patients.
Once you complete the online evaluation , a certificate will be automatically generated.
Once you have completed the article , you may then take the examination again for CME credit.
On-chip microfluidic cell culturing is an indispensable technique for cellular replacement therapies and experimental cell biology.
OncoActive participants received both Web-based and printed materials.
Onco-cardiology is a medical subspecialty that focuses on the diagnosis and treatment of cardiotoxicity in cancer patients.
Oncocytomas are benign tumors most often occurring in salivary or lacrimal glands and thyroid tissue.
Oncogene activation is an established driver of tumorigenesis.
Oncogene induced CS can be promoted by the loss of tumor suppressor genes , such as PTEN.
Oncogene-induced senescence ( OIS ) is a potent tumor-suppressive mechanism that is thought to come at the cost of aging.
Oncogenes are pro-proliferative genes that promote survival and proliferation of cancer cells.
Oncogenic features of miR-182 confirmed through negative regulation of various tumor suppressor genes.
Oncogeriatrics proposes the geriatric evaluation of elderly patients to improve therapeutic choices and optimize the management of treatment toxicities and comorbidities.
Oncologists need excellent communication skills to effectively handle challenging conversations regarding prognosis , transition to palliative care , code status , and other sensitive topics.
Oncology nurses are in a key position to assist patients with MDS to maintain their QOL.
Oncology nurses will be centrally involved in healthcare innovations , such as rapid learning systems , and as key members of a well-trained workforce.
Oncometabolites are defined as small-molecule components ( or enantiomers ) of normal metabolism whose accumulation causes signaling dysregulation to establish a milieu that initiates carcinogenesis.
On completion of the study each perineometer exercise session was rated for technique by @number@ raters , blinded to the patient and order of sessions.
On completion of this review , it was possible to conclude that this drug has an antidopaminergic mechanism of action.
On @date@ , a comprehensive smoking ban was implemented in Taiwan.
On @date@ , we searched the major databases for new studies for future evaluation.
On Day @number@ Hct was @number@ ± @percent@ and still reduced below baseline ( p = @number@ ) .
On day @number@ intensive PK sampling was undertaken in a fasted state and RAL plasma concentrations determined.
On day @number@ of pregnancy , RU ( 4mg / kg ) was injected subcutaneously to induce embryo implantation failure.
On Day @number@ subjects were instructed ( humans ) or cued ( rats ) to recall Set @number@
On Day @number@ two retention tests ( Day 1 / Day @number@ ) were conducted.
On days in which middle-age and older adults and individuals with lower health used more SOC , they also reported greater happiness.
On detailed microscopic examination , fine beta amyloid-containing and beta sheet-rich thread-like structures were found in the peri-axonal space of many axons.
On discharge , there was a significant difference between the two groups ( functional capacity , P = 0.039 ) .
One- , 3- and 5-year cumulative incidences of psychosis were calculated.
One , 3- , and 5-year survival was lower for patients with no insurance and Medicaid than for patients with other insurance.
One 84-year-old female patient died due to perioperative endocarditis.
On each trial , participants selected the target at increasingly longer retention intervals , contingent upon successful recall.
On each trial , subjects reported which reference face matched the test face ( shown with different poses and / or expressions ) .
One advantage of this approach is that memory and guessing processes can be assessed independently.
One and @number@ weeks later , two neutral , blinded observers assessed the subjects in person.
One approach for mobilizing multi-level efforts to improve the environment for physical activity is to engage in a process of citizen science.
One approach to expedite aging studies is to take advantage of mouse strains that are engineered to age rapidly.
One approach to the examination of genetic influences on the volumes of brain structures is to determine their heritability using twin and family studies.
One area in which this development plays out is in the acquisition of between co-occurring elements in a word , phrase , or sentence.
One area of concern is the impact of trauma and post traumatic stress disorder ( PTSD ) in the aged.
One area that may be underutilized is accessing Veteran benefits.
One article was published in the @number@ s , two in @number@
One aspect of \ "accelerated aging \ " in depression may be shortened leukocyte telomeres.
One aspect of ageing research focuses on the molecular profiling of the changes that occur with increasing age in humans.
One aspect of cognitive function that is critical for everyday function is episodic memory.
One aspect of vitreous aging is liquefaction , which results from the vanishing of collagen fibrils.
One association appears to be driven by an amino acid substitution encoded in EXO1.
One assumes that the myocardium of an adult human heart has a weak regenerative capacity.
One atypical femoral fracture and two cases of osteonecrosis of the jaw were observed in the romosozumab group.
One author ( TV ) has a patent interest in SpIn.
One avenue to explore is the concept of COPD as a trans-generational disease.
One barrier to the expansion of geriatric health care providers is the limited desire of nursing students to work with older adults.
One beer had sulfuric and fecal off-flavors ; it was bright with the original extract of @number@.3° Plato.
One-carbon nutrient concentrations were measured in fasting serum samples collected at baseline ( up to @number@ years prior to cancer diagnosis ) .
One case had postinflammatory hyperpigmentation on only the side treated with fractional erbium-doped glass.
One case of CRPS-1 performed conservative treatment , the therapy was effective.
One case underwent liver biopsy , with the bile ducts showing marked damage , fulfilling the criteria for vanishing bile duct syndrome.
One case was differentiated toward myeloid proliferation , suggesting granulocytic leukemia.
One challenge in revision total hip arthroplasty is dealing with acetabular defects.
One challenge in these prevention trials is sample recruitment bias.
One challenge lies in the enormous mechanistic distance between genotype and downstream ageing phenotypes.
One chapter is devoted to the important discoveries that have been made by using genetically encoded redox indicators.
One compelling example of this is how our new approach can be a useful tool in drug repositioning.
One complicating factor is genetic trade-off.
One concern , however , is that BFR during exercise may place unnecessary burden on those with compromised cardiac function.
One conclusion is that there may be important aspects of human aging that can be studied only using long-lived animals.
One consequence of this development is that the need for tools for the evaluation of both functional and global status of the elderly increases.
One construct frequently used in this context is subjective age , that is , how old or young a person feels.
One contributing factor to this uncertainty is the paucity and variability of experimental data on lens stiffness.
One control participant withdrew before follow-up data collection.
One could expect that direct pharmacological activation of the signaling can produce a stronger antiaging effect than that achieved by the indirect hormonal stimulation.
One critical point is that new generations of targeted nanoparticle based drugs are developed and optimized for certain metabolic conditions.
One critical ROS is hydrogen peroxide , which is naturally degraded by catalase in peroxisomes or glutathione peroxidase within mitochondria.
One difference that might play a role in lowering the predictivity of mice models to human diseases is age.
One difficulty in reconciling the conflicting results is the lack of integration across the neuroscience sub-disciplines that contribute to the field.
One disease-associated enhancer showed statistically significant association to low serum 25-hydroxy vitamin D levels ( Pearson chi-square P-value = 0.009 ) .
One disease intimately associated with PMSO formation and loss of MsrA activity is age-related human cataract.
One dispositional emotion regulation strategy , dispositional cognitive reappraisal , was also assessed.
One distinct haploblock in PSEN2 was detected and the frequent haplotypes were analyzed using @number@ tagging single nucleotide polymorphisms ( SNPs ) .
One distortion involves the erroneous incorporation of features from one episodic memory into another , forming what are known as memory conjunction errors.
One domain of cognitive function particularly susceptible to age-related decrements is spatial memory.
One dream per participant was scored by two independent judges using content analysis.
One early and prominent pathologic feature of Alzheimer's disease ( AD ) is the appearance of activated microglia in the vicinity of developing β-amyloid deposits.
One elderly subject was excluded from the pharmacokinetic analyses because of apparent noncompliance with armodafinil dosing.
One emerging strategy to decrease the prevalence of mild cognitive impairment and dementia may be the use of nutritional interventions.
One environmental factor that is implicated in both of these states is tissue hypoxia , which increases with aging and can inhibit senescence.
One epigenetic mechanism implicated in human aging and age-related disorders is DNA methylation.
One essential reason for skin ageing is the formation of free radicals by excessive or unprotected sun exposure.
One event associated with loss of any of these genes is altered mitochondrial function.
One example is syndromes of dementia.
One expected consequence of this is an increase in morbidity and an associated increased demand for long-term care.
One experienced specialist in cardiovascular disease and one experienced neurosurgeon determined the number of lacunar infarctions on brain MRI.
One explanation could be a specific loss of cells containing mitochondria loaded with Hb proteins.
One explanation for these observations is age stigma ( ie , stereotypes linked to age , and thus ageism ) .
One explanation for this phenomenon is the complex role testosterone plays in multiple physiologic pathways.
One explanation is a generalized impairment in the processing of associative information.
One explanation is that the general population is aging , driving prison age distributions to change.
One extensive , noncontiguous duplication on chromosome @number@ was consistent with an unbalanced translocation not including the Down's syndrome critical region.
One factor evidently important for neuronal health and function is the optimal supply of nutrients necessary for maintaining normal functioning of the brain.
One factor may be reliance on leukocytes , which are composed of varied immune cell types , as the sole measure of telomere length.
One factor may be the concurrent use of over-the-counter ( OTC ) medicines.
One factor that is proposed to be critical in determining the efficacy of hormone therapy is the timing of its initiation.
One factor that may account for the variability is whether the manipulations inadvertently involve strategic , explicit processes.
One factor that may play a role in mitigating age-associated brain decline is cardiorespiratory fitness ( CRF ) .
One factor that may play a role in older adults with ADHD is an increased risk of experiencing adverse life events.
One factor that might contribute to the mixed findings regarding age differences in familiarity is the estimation method used to quantify the two mnemonic processes.
One fifth of programs lacked specific instruction in geriatric psychiatry.
One-fifth or more of older adults reported receiving uncoordinated care in all countries except France.
One found an improvement in adherence but not health outcomes.
One-fourth of patients with CRAO have cerebral strokes.
One frameshift ( c.1414delA ) and @number@ missense variants of uncertain significance in TBK1 were found in @number@ patients each.
One frequently used repetition priming task is word-stem completion priming.
One fundamental aging process that is often operative at sites of the pathology underlying chronic age-related diseases is cellular senescence.
One gene that experiences LOI is the paracrine insulin-like growth factor
One goal of aging research is to find drugs that delay the onset of age-associated disease.
One goal was to create a multifactorial recruitment and retention strategy.
One group trained with only haptic information and the other group with both haptic and visual information about relative phase.
One-half of fallers ( @percent@ ) sustained an injury.
One half of the face was treated with a Single Pulse while the other half was treated with energies divided into a DP.
One hemisphere was perfused-fixed to render an optimal fixation for conducting neurostereological studies.
One heterozygous missense p.Phe121Ser mutation was detected in a healthy 76-year-old control subject and no other TMEM230 mutations were found in PD patients and controls.
One hospital implemented the Prevention and Reactivation Care Program ( PReCaP ) , while two other hospitals providing usual care served as control settings.
One hour prior to the onset of symptoms , he received levobunolol hydrochloride solution topically.
One hundred and eight eyes of @number@ emmetropic subjects ( ± @number@ dpt ) served as reference group.
One hundred and eighty-eight were male and @number@ female.
One hundred and eighty-two children aged three to six years were recruited from nine day care centers in central Taiwan.
One hundred and fifty-six subjects aged over @number@ years were enrolled.
One hundred and fifty teeth were randomly divided into five main groups according to surface conditioning procedures.
One hundred and fifty three ambulatory , non-diabetic adults aged @number@ years and older were studied.
One hundred and five of them fulfilled the study criteria and were self-reported healthy elderly.
One hundred and forty-eight people , with a mean age of @number@ years , were recruited from @number@ assisted-living facilities in the USA.
One hundred and forty-five patients were randomized to receive senicapoc and @number@ patients to receive placebo for @number@ weeks.
One hundred and forty-nine community-dwelling older adults served as controls.
One hundred and ninety-one participants completed the study and the data of @number@ participants were included in the final analysis.
One hundred and ninety-one ( @percent@ ) met standard ( @number@ mmHg systolic / 10 mmHg diastolic ) criteria for OH.
One hundred and seventy-five melanocytic lesions from @number@ patients were evaluated at both time points.
One hundred and seventy-two caregivers of patients suffering from Alzheimer's type dementia participated in the study.
One hundred and sixty eight women ( @percent@ ) had knowledge of HRT and only @number@ ( @percent@ ) had taken it in the past.
One hundred and three residents with @number@ ± @number@ years-of-age included.
One hundred and twenty-five participants enrolled , and annual follow-up has been @percent@.
One hundred and twenty human third molars were sectioned in order to expose the dentin surface ( n = @number@ ) .
One hundred and twenty six individuals aging between @number@ to @number@ years participated in this study.
One hundred and twenty-two elderly subjects living in Palermo city participated to the study.
One hundred and two individuals were screened for psychiatric illness.
One hundred and two patients were treated in Nottingham University Hospitals ( a regional centre for neurosurgery ) during the period 1986-2008.
One hundred and two ( @percent@ ) subjects had two-plus syncopal events in the same period.
One hundred eighteen patients ( %42.1 ) had MetS.
One hundred eight ( @percent@ ) subjects clinically progressed after @number@ ( IQR @number@.3-3.0 ) years.
One hundred eighty-eight relevant studies were identified.
One hundred eighty-three of @number@ completed the intervention and @number@ of @number@ completed the study.
One hundred employers were interviewed using structured questionnaires and @number@ employers by additional in-depth interviews.
One hundred fifteen independent-living older adults ( ages 70-92 years ) were included.
One hundred fifty cylinder specimens were built using a nanohybrid RBC ( base cylinder ) .
One hundred fifty seven physically independent individuals , aged @number@ years or older were evaluated.
One hundred forty-eight participants developed dementia during follow-up , and @number@ remained dementia-free.
One hundred forty-four out of @number@ patients ( @percent@ ) had an abnormal test score and / or had subjective cognitive complaints.
One hundred forty-three participants ( 22-78 years ) underwent an episodic memory experiment where item-context relationships were encoded and tested twice.
One-hundred ninety-eight patients were included with a mean age of @number@ ± @number@ years old , and @number@ % were female.
One hundred ninety-five ( @percent@ ) completed 12-week follow-up.
One hundred older HIV + adults completed the International Physical Activity Questionnaire , a neurocognitive battery , and IADL scale.
One hundred seventy of these had IG.
One hundred ten patients participated , mean age @number@ @percent@ women.
One hundred ten patients with a diagnosis of PD without dementia were evaluated.
One hundred thirty-four concurrently underwent fluorodeoxyglucose ( FDG ) -PET.
One-hundred-thirty-four normal subjects ( @number@ eyes ) were included.
One hundred thirty-three healthy subjects were enrolled in this study.
One hundred three HIV-infected individuals aged @number@ and older were recruited from the Modena HIV Metabolic Clinic in Italy.
One hundred twenty-one cognitively normal old participants received comprehensive clinical evaluations and brain diffusion tensor imaging on @number@ occasions.
One hundred twenty-two older adults with single-domain or multiple-domain amnestic MCI were recruited from memory clinics.
One hundred twenty-two patients were followed up during @number@ years.
One hypothesis suggests that obesity contributes to insulin resistance through increased production of adipose-derived inflammatory cytokines.
One hypothesized approach is the application of a topical anti-oxidant to reduce free-radical induced aging.
[ O'Neill et al.
One important aspect of acute stress exposure that may underlie detrimental effects on health is physiological reactivity to the stressor.
One important goal of driving research is the development of a short but valid office-based screening test for fitness to drive of aging drivers.
One important mechanism contributing to the onset of the aging. process is the disturbance of the cellular redox homeostasis.
One important process in liver cancer growth and progression is angiogenesis.
One important target of damage is the brain.
One important use of transgenic mouse models of SOD1-ALS is the study of genetic influences on ALS severity.
One indicator of smoothness is the similarity of the body movements of the two individuals concerned.
One indicator of this age-related deficit is older adults ' difficulty in detecting and correctly rejecting new associations of familiar items.
One in five older adults in Taiwan have been diagnosed with diabetes.
One influential hypothesis is that the posterior cingulate cortex has a central role in supporting internally-directed cognition.
One in four older adults lives with depression , anxiety disorders , or other significant psychiatric disorders.
One in @number@ experience frequent healthcare discrimination , and this is associated with new or worsened disability by @number@ years.
One in @number@ patients suffering a hip fracture will die within a year.
One interesting idea is that species-specific rate of aging represents a ratio of tissue attrition to tissue regeneration.
One intervention option for management of the most severe to profound hearing loss in older adults is cochlear implantation.
One investigator used significantly less volume with Artiste than with manual injection ( @number@ mL vs @number@ mL ; P = @number@ ) .
One issue is whether amyloid and tangle pathology , features of AD , or α-synuclein LB pathology have similar or different effects on brain inflammation.
One is telomere-dependent replicative senescence and the second is stress-induced premature senescence ( SIPS ) .
One item of the original BBS was not loaded in these factors.
One key enzyme thought to be activated during CR is the AMP-activated kinase ( AMPK ) , a sensor of cellular energy levels.
One key example of social engagement in later life is the role of a grandparent.
One key issue that is in common to these processes is oxidative damage.
One key phenotype as the brain ages is an aberrant innate immune response characterized by proinflammation.
One large national system is redefining how it cares for patients in the acute care setting in preparation for the Next Era.
One limitation of many of these studies is their reliance on self reported data.
One locus identified using HapMap imputation was not significant using 1000G imputation.
One low PiB HC developed MCI.
One main source of oxidative stress is the error-prone process of the respiratory chain located in the mitochondria.
One major aspect is the estimated higher treatment costs in the care of the elderly.
One major aspect of this specificity is ROS compartmentalization within membrane-enclosed organelles such as redoxosomes ( redox-active endosomes ) and the nuclear envelope.
One major hurdle to the development of effective treatments to many diseases is the lack of suitable human model systems.
One major pathologic hallmark and trigger of Alzheimer's disease ( AD ) is overproduction and accumulation of β-amyloid ( Aβ ) species in the brain.
One may therefore wonder how reliable the result of age assessment performed without knowing the racial group to which the subject belongs may be.
One measure of cellular aging is the telomere.
One mechanism we have demonstrated for decreased AID includes increased mRNA degradation of the transcription factor E47 , critical for AID transcription.
One method to monitor adherence is to compare observed weight loss to the expected weight loss during a prescribed level of CR.
One mild hypertrophic scar responding to steroid injection over the mastoid area was observed in the entire series.
One-minute digital images acquired every @number@ min for @number@ min were used to calculate a simple half-time of emptying.
One minute epoch data was used to perform SAX , which converted accelerometry time series data into four activity levels.
One ml saliva and @number@ ml whole blood were collected from each person.
One month after intervention implementation , @number@ additional day of observations was conducted to determine data reliability.
One-month pioglitazone administration also restored PPAR-γ expression and increased the levels of UCP2 in aging rat cerebral arteries.
One month postoperatively , best-corrected visual acuity increased from @number@ to @number@ logarithm of the minimum angle of resolution.
One most compelling example is that pre-feeding easily oxidizable organic matter can promote the oxidation of refractory organic compound when it was treated by AOPs.
One night of mild sleep disturbance was not associated with decreased cognitive performance the next day.
One novel approach to address this challenge is to administer drugs intranasally to noninvasively bypass the blood-brain barrier.
On entry into residential care , they exhibit greater frailty in terms of activities of daily living , cognition , aggression , and incontinence.
One @number@ g / kg female died during the last week of the study.
One obvious cause seems to be that all previous human studies may have been underpowered.
One of endogenous sources of ROS is mitochondria.
One of the approaches to increase yield is to delay leaf senescence and to extend the available time for photosynthesis.
One of the basic factors glycation of HSA occurs in diabetes and may affect HSA-drug binding.
One of the best examples of a gene that positively influences cognitive health is the apolipoprotein ( APOE ) ɛ2 allele.
One of the best predictors of suicide in older adults is suicide ideation ; suicide ideation has been frequently associated with depression.
One of the biggest challenges in biology is to understand how mitochondria influence aging and age-related diseases.
One of the biggest questions in learning is how a system can resolve the plasticity and stability dilemma.
One of the cellular markers of neuroinflammation is increased microglia activation , characterized by overexpression of mitochondrial 18kDa Translocator Protein ( TSPO ) .
One of the central factors affecting client engagement is the challenge it poses to traditional power relations inherent in care relationships and contexts.
One of the characteristic hallmarks of AD is the presence of neurofibrillary tangles , composed of microtubule-associated , abnormally hyperphosphorylated tau protein.
One of the characteristic natures of senescent cells is the hypo- or irresponsiveness not only to growth factors but also to apoptotic stress.
One of the complications seen after coronary artery bypass grafting is vasospasm.
One of the consequences of age-related failing MQC and oxidative stress is the release of mitochondria-derived damage-associated molecular patterns ( DAMPs ) .
One of the consequences of this trend is the increase of hospitalisation of elderly patients.
One of the earliest markers of AD is oxidative DNA damage.
One of the end-stage leukemia patients of our hospital hoped to die at home.
One of the few proven methods for reducing ageist ideation is through participation in a video screening and a pair of follow-up conversations.
One of the first events in MVD is endothelial dysfunction.
One of the first signs of aging belongs to the upper third of the face.
One of the fundamental rights of every human being is to enjoy \ "the highest attainable standard of health \ ".
One of the fundamental strategies for the maintenance of the satisfaction of new needs that have arisen is the promotion of self-care.
One of the important factors in the development of arterial hypertension is the state of lipids peroxidation.
One of their future challenges is to recognise and assess nutritional status among this group.
One of the key drivers of aging is cellular senescence , a state of irreversible growth arrest induced by many pro-tumorigenic stresses.
One of the key pathways mediating protein degradation is proteosomal protein destruction.
One of the key stages of life of a cell is genome duplication.
One of the limitations of research into diabetic retinopathy is the lack of suitable animal models.
One of the little known ironies in the field of prison health is the notion that prison may actually have health-stabilizing effects for some groups.
One of the main difficulties in facial age estimation is that the learning algorithms cannot expect sufficient and complete training data.
One of the main features of human aging is the loss of adult stem cell homeostasis.
One of the main findings is the implication of mitochondria in the age-associated oxidative stress.
One of the main manifestations of vascular aging is the development of atherosclerotic lesions.
One of the major age-related arterial phenotypes thought to be responsible for the development of CVD in older adults is endothelial dysfunction.
One of the major causes may be cerebral hypoperfusion.
One of the major causes of reduced vision over the age of @number@ is age-related macular degeneration ( AMD ) .
One of the major challenges for the Liguria region is to face the increasing demand for oncology services.
One of the major clinical consequences of the gastric frailty is the higher vulnerability to the occurrence of peptic ulcer disease during ageing.
One of the major problems in the development of information and communication technologies for older adults is user acceptance.
One of the major sources of such protein damage or ageing is the conversion of aspartate into isoaspartate residues that can then be methylated.
One of the major sources of vascular endothelial damage is oxidative stress.
One of the mechanisms responsible for these functions is RNA editing.
One of the most aggressive manifestations of age-dependent and dysbalanced wound healing is a disease called idiopathic pulmonary fibrosis.
One of the most applied therapeutical approaches to correct altered gait patterns is the insertion of insoles.
One of the most common causes of death among the elderly is the cardiovascular disease ( CVD ) .
One of the most commonly used methods for visualizing biological data is the Venn diagram.
One of the most common procedures for hospitalized adults @number@ years and older is mechanical ventilation.
One of the most common sensory impairments of elderly people is hearing loss.
One of the most consistent findings in the biology of depression is an altered activity of the ( HPA ) axis.
One of the most frequently observed lesions in clinical forensic practice concerns the patterned abrasion on skin due to constriction by various types of ligature.
One of the most important goals in the management of older , frail people is to optimize their nutritional status.
One of the most important risk factors for CV disease is hypertension that is very often related to obesity and metabolic syndrome.
One of the most important variables of the AMIS NS system is the variable Jung which stands for the interrelationship unified mortality predictors.
One of the most influential findings is that human brain networks exhibit prominent small-world organization.
One of the most outstanding pillars of the frailty syndrome is the loss of muscle quantity and function , referred to as sarcopenia.
One of the most popular therapies is cognitive training , which includes pencil-and-paper puzzles , computerized games , or the combination of the two.
One of the most potent activators of NO production is fluid shear stress produced by blood flow.
One of the most prominent age-related diseases is ischemic stroke.
One of the most prominent alterations during aging is the continuous involution of the thymus gland which is almost complete by the age of @number@
One of the most prominent features of cachexia is the loss of muscle mass , mainly because of increased protein degradation rates.
One of the most prominent HuR target circRNAs was hsa circ 0031288 , renamed CircPABPN1 as it arises from the PABPN1 pre-mRNA.
One of the most reliable findings in psychiatry is in the incidence of anxiety and depression.
One of the most requested procedures is treatment with botulinum toxin type A ( BoNTA ) .
One of the most significant human rights tribunals in Europe is the European Court of Human Rights ( ECtHR ) .
One of the most spectacular exogenous prooxidative agents is cigarette smoking.
One of the most successful interventional measures that slows down and delays age-related kidney disease is caloric restriction.
One of the most widely investigated factors is an age-related reduction in attentional resources.
One of the most widespread approaches to the epigenetic alterations in cancer and aging is dietary control.
One of them uses a nonlocal scalar field.
One of the neuropathological features of AD is the presence of extracellular amyloid plaques , which are mainly composed of amyloid-β ( Aβ ) peptides.
One of the novel non-coding RNAs was switched on in mutant testes compared to controls.
One of the possible approaches is to develop dysphagia diets that facilitate swallow initiation.
One of the primary biological roles recently conferred to Lamin A / C is to affect contractile cells lineage determination and senescence.
One of the primary goals in the diagnostic evaluation in patients with hip pain is to identify and correct pathologies that could progress to osteoarthritis.
One of the primary mechanisms is the unfolded protein response ( UPR ) .
One of the principal auditory disabilities associated with older age is difficulty in locating and tracking sources of sound.
One of the principal modes of action appears to be as antioxidant.
One of the reasons could be the use of autologous aged ADSC , which recently were found to have impaired functions.
One of the reasons for this is the increase in the number of patients with diabetes.
One of the reasons was the systematic education of the case studies.
One of the risk factors for developing cardiovascular disease ( CVD ) is aging.
One of these institutions organized trips to Central and South America to get the operation done.
One of these loci confirmed a previously identified locus ( ahl8 ) on distal chromosome @number@ and greatly narrowed the candidate region.
One of these processes is adolescent development.
One of these regions is the dentate gyrus of the hippocampal formation , a key structure in memory.
One of these studies suggested that there might be decreasing levels in persons aged @number@ years and older.
One of the strategic objectives of the 2011-2020 Global Vaccine Action Plan is for the benefits of immunisation to be equitably extended to all people.
One of the strongest modulators of chronic inflammation is diet.
One of the strongest risk factors for dementia is the ε4 variant of the APOE gene.
One of the top-ranking articles was also highly cited.
One of the underlying causes for this is the massive change in the hormonal milieu of the body.
One of the ways to repair the expression of heat shock proteins is using short peptides.
One of two Minos insertion mutants to unknown function gene ( CG31414 ) accumulates the hydroxy-GlcCer in whole body of Drosophila melanogaster.
One-on-one interviews were conducted to measure the cognitive abilities of the participants , and @number@ valid samples were collected.
One-on-one interviews were conducted with HHCW to elicit frequency of daily occupational exposures to hazards and risk factors during visits to patients ' homes.
One or more complications occurred in @number@ patients ( @percent@ overall ; @percent@ EVAR and @percent@ OAR ) .
One or more of these reflexes was identified in @number@ patients ( @percent@ ) .
One or more of these symptoms will affect nearly all people with dementia over the course of their illness.
One or more symptoms of anxiety were exhibited for @percent@ ( RAID ) and @percent@ ( CAS ) of participants.
One out of @number@ escitalopram patients had a QTcF interval > 500 ms and a change from baseline > 60 ms.
One particular challenge is an increase in chronic kidney disease , the prevalence of which is higher in older people.
One particularly effective intervention strategy that has been identified is exercise , whether individually prescribed or conducted in group-based settings.
One particular measure utilized by rehabilitative professionals in evaluating functional declines in older persons is sit-to-stand ( STS ) capacity.
One pathophysiologic mechanism hypothesized to contribute to treatment resistance in depression is inflammation.
One patient accepted CT guided biopsy.
One patient died due to an intraoperative complication.
One patient exhibited a mild exacerbation of his ptosis.
One patient experienced retroauricular infection.
One patient experienced unilateral temporal nerve injury , @number@ experienced hematoma , and @number@ had wound dehiscence.
One patient group was treated with inclusion of hyperthermia therapy and the other group without.
One patient needed revision for aseptic loosening.
One patient ( @number@ percent ) developed lower eyelid retraction requiring subsequent lower eyelid tightening.
One patient ( @percent@ ) died during her post-operative hospital stay.
One patient required multiple awake fiberoptic intubations.
One patient showed scars of the lower lids after excision of a squamous cell carcinoma and a basal cell carcinoma.
One patient underwent a major complication with a vascular leakage responsible for a cement pulmonary embolism.
One patient was lost to follow-up , and one died with extensive metastasis , paraplegia , and renal failure.
One patient with a history of stroke died due to large-vessel hemispheric stroke after @number@ months on treatment.
One patient with PHP-Ia was diagnosed with growth hormone deficiency and showed a good response to human recombinant growth hormone therapy.
One PHP-Ib patient showed a de novo microdeletion in STX16 and a loss of methylation of exon A / B on the maternal allele.
One-piece abutments made of zirconia showed significantly lower fracture resistance.
On episodic memory measures , YA performed better than high-fit OA , who in turn performed better than low-fit OA.
One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases.
One point represented the most positive possible score , and three points the most negative.
One polymorphism rs515071 was identified to be a potential risk factor for type @number@ diabetes ( T2D ) .
One popular candidate is curcumin or diferuloylmethane , a polyphenolic compound that is the main curcuminoid found in Curcuma longa ( family Zingiberaceae ) .
One possibility is that by contributing to cerebral microvascular damage , OSA may exacerbate progressive memory decline.
One possibility is that inflammation associates with adverse changes in brain morphology , which accelerates cognitive aging and later dementia risk.
One possibility is that low levels of androgens throughout life reduces aging rate , but late-life androgen depletion does not.
One possibility is that PDE5i exacerbates age-related susceptibility to hearing loss in adults.
One possibility is that the neuroendocrine responses to stress exposure are involved.
One possible cause of this increase is the aging of the population , which results in more comorbidities in high income countries.
One possible confounding factor is due to the influence of gene-related modulator.
One possible explanation for the individual differences in outcomes of stress is the diversity of inputs that produce perceptions of being stressed.
One possible explanation for this association is that dairy foods may serve as a good source of substrates for glutathione synthesis in the human brain.
One possible factor is the amount of concurrent cognitive training received during the training program.
One possible mechanism for such deficits is an age-related reduction in available processing resources.
One possible mechanism of the ageing heart is a cellular senescence.
One possible pathway linking these two phenomena is lacunar infarction , a potential cause of dementia.
One possible reason for the under-prescription of pharmacological treatments for osteoporosis in the oldest old is the perception that anti-fracture efficacy requires long-term treatment.
One possible reason for this difficulty is that it may take them longer to perceptually segregate the target speech from competing speech.
One postulated mechanism for essential tremor is the over-excitation of glutamatergic olivo-cerebellar climbing fibers , leading to excitotoxic death of Purkinje cells.
One potential class of health care innovation that may offer an alternative approach to addressing current shortfalls is stem cell therapies.
One potential explanation for APOE's pleiotropic roles may lie in its unique epigenetic properties.
One potential explanation for this is enhanced optimism.
One potential mechanism for MGRN1 monoubiquitination is via progressive deubiquitination at the proteasome of polyubiquitinated MGRN1.
One potential strategy for improving recognition of ADRs is to identify those patients who are at risk of an ADR.
One potential treatment , farnesyltransferase inhibitor , ameliorates some of these effects.
One presumed pathway is through disconnection of functional networks.
One problem with previous studies is a tendency to treat emotion as a dichotomous variable.
One promising alternative to event-related fMRI is a resting-state-derived functional connectivity approach.
One promising biomarker is beta amyloid ( Abeta ) deposition.
One proposed hypothesis is that depression may cause HcV loss.
One proposed mechanism leading to glomerulopathy is an increase in leptin levels.
One proposed model suggests that synaptic activity leads to increased Aβ deposition.
One proprioception test ( kinesthesia ; p = .003 ) showed gender differences ( females more accurate ) .
One public arena where this engagement is particularly evident is within the Swedish news-press , where articles on loneliness among older people are frequently published.
One putative marker of biological aging is leukocyte telomere length ( LTL ) , which typically shortens with age.
One-quarter of mothers ( n = 38 ) reported implausible answers concerning age-of-introduction of liquids and foods.
One quarter of sites discussed contraindications to treatment , with @percent@ of sites detailing follow up patient care.
One reader's sensitivity and specificity for sCJD was @percent@ and @percent@ , respectively , the other's was @percent@ and @percent@.
One reason for the mixed results could be the presence of interaction effects with other AD risk factors.
One reason for this appears to be a concern about a possible risk of bradyarrhythmia associated with use of β-blockers.
One recent report suggests these differences are evident at @number@ years of age.
One region proved to be differentially methylated with obesity ( LINC00304 ) independent of age.
One reliable way to evaluate voice quality is through acoustical analysis using , for instance , the long-term average spectrum ( LTAS ) .
One-repetition maximum strength testing may result in a greater injury risk.
One researcher conducted 2-day site visits over a two-month period to complete all interviews and FGs.
One review author extracted methodological quality data.
One route was followed by a 10-min rest and the other by a 10-min spot the difference game.
One sample t-tests evaluated whether mean discrepancy scores in each group were comparable to zero ( i.e. , accurate ) .
One SD increase in baPWV resulted in a 2-fold increase in the odds of being Aβ-positive ( p = @number@ ) .
One selective inducer of ADAM10 gene expression is the X-box binding protein-1 ( XBP-1 ) .
One serious AE ( infection ) was thought to be related to treatment with polyacrylamide hydrogel ; it resolved within @number@ days after appropriate treatment.
One side of the patient's face received vibration together with dermal filler injections , whereas the other side received dermal filler injections alone.
One site was pretreated with topical anaesthetic cream to block local sensory nerve function.
One's memory for past test performance ( MPT ) is a key piece of information individuals use when deciding how to restudy material.
One SNP , rs2836016 , was found to be associated with alcohol dependence ( p = 0.01 , false discovery rate ) .
One solution to this problem has been to investigate subjective and objective memory longitudinally , thereby focusing on individual differences in intraindividual changes.
One specific organelle that has vast implications on the overall health of the cell and cellular viability is the mitochondrion.
One's social network type can be an important initial indicator that one is at risk.
On estimation trials , subjects moved their hand along a robot-generated constrained pathway.
One strategy incorporates prisoner volunteers into end-of-life services within a peer-care program.
One strategy to reduce the effect of oxidative stress produced by environmental exposure is the application of antioxidant molecules.
One study assessed a core set of the International Classification of Functioning , Disability and Health ( ICF ) framework.
One study disclosed a high incidence of dementia among patients suffering from atrial fibrillation during a @number@ years follow-up.
One study found that participants with less-complex medication administration were more likely to stop medications when feeling worse.
One study included an intervention to temporarily mitigate hearing loss to improve communication.
One study incorrectly randomized participants , and another was a reanalysis of RCT data.
One study observed that the neuroprotective effect of these agents is possibly due to an anti-Aβ effect produced by cholinergic stimulation.
One study of rural women in Monteverde reported that women knew little about the menopausal transition , as the subject was not discussed.
One study was performed on human reconstructed skin in vitro with a semi-global gene expression analysis of @number@ genes in fibroblasts and @number@ in keratinocytes.
One subject experienced a small myocardial infarction from an unrecognized small branch coronary occlusion.
One subject presented changes in SSEP @number@ and @number@ months after mesenchymal stem cells transplantation.
One such agent , glucosamine ( GlcN ) is commonly prescribed even though the therapeutic efficacy and mechanism of action remain controversial.
One such autoantibody synergized with Hb to enhance the secretion of pro-inflammatory cytokines while eliciting the increased production of monocyte migratory signals from endothelial cells.
One such condition is osteoporosis ( fragile or porous bones ) , which causes an increased fracture risk.
One such disorder is Huntington's Disease ( HD ) that is caused by a polyglutamine expansion in the human huntingtin protein ( htt ) .
One such framework theory , the cross-culturally universal vitalist biology , gives meaning to the abstract concepts life and death.
One such hormone , vitamin D , exerts broad-ranging effects in muscle and bone calcium handling , differentiation and development.
One such mechanism is deregulation of CREB-regulated transcriptional coactivators ( CRTCs ) .
One such metabolic risk factor could be high cholesterol levels in the body.
One such method is LED-based therapy.
One such risk factor , high-homocysteine levels in the blood , is known to increase risk for Alzheimer's disease and vascular disorders.
One suggested pathway is that pollution causes oxidative stress.
One suggested pathway is via oxidative stress.
One task assesses the preference using nine presentations of objects ; the other uses @number@ presentations.
One technique that employs an integrative approach to measure mitochondrial function is respirometric oxidative phosphorylation ( OXPHOS ) analysis.
One-third also scored high-risk of bleeding using HAS-BLED or HEMORR2HAGES.
One third of elderly persons show no decrease in renal function ( GFR > @number@ mL / min / 1.73 m2 ) .
One third of hospitals have alternatives to inpatient care , the most frequent being palliative care.
One-third of them ( n = @number@ ) were frail.
One-third of the @number@ carbonylated proteins identified here are regulated during apoptosis.
One-third of the respondents expressed a desire to be at home.
One third of the sample reported pain and the mean positive affect score was @number@ ( range 0-12 ) .
One third of women at @number@ years or more after menopause continued to experience moderate / severe hot flashes.
One third ( @percent@ ) of population had co-morbidities and @percent@ were on chronic concomitant treatments.
One-third reported that their UI started before their HF diagnosis.
One-third was Black , and @percent@ were Caucasian.
One thousand and eighty three participants owned cats and @number@ participants owned dogs.
One thousand forty-seven cognitive evaluations were performed.
One thousand sixty-three participants also received supplemental neurocognitive battery and neuroimaging studies.
One thousand two hundred eighteen people residing in @number@ dementia care homes were involved.
One thousand two hundred eighty-seven community-dwelling elderly were included.
One to @number@ vertebrae were augmented per case ( average @number@ ) .
One tool to evaluate and report the quality of clinical health services is quality indicators based on a clinical database.
One-to-one propensity matching was performed on demographics and comorbidities to create a matched sample.
One trial had a high risk of bias.
One universal dietary recommendation regarding snacking and meal frequency is not appropriate for every life-stage group.
One valid instrumental variable was available in women only ( rs6905288 ) , which was associated with GMV ( p = @number@ ) .
One vertebra was used for calibration of the material properties from experimental results and CT gray-scale values.
One volume and seven process quality indicators on dementia evaluations are monitored.
One was a case of pulmonary thromboembolism and the other was one of superior mesenteric artery thromboembolism.
One was a correlation between good hearing and a high consumption of fish in the male group.
One was diagnosed as having NMS because of exposure to risperidone.
One was hybrid-structured FDPs comprising CAD / CAM-fabricated porcelain parts adhering to a CAD / CAM fabricated zirconia framework.
One was to establish multi-disciplinary teams of investigators who use systems biology approaches and stem cell technology to identify a new generation of AD targets.
One-way analysis of variance and the Tukey's post hoc test were used to compare the groups ' significance statistically ( α = @number@ ) .
One-way analysis of variance ( ANOVA ) with repeated measures and Tukey's test were performed at a significance level of @percent@.
One-way analysis of variance was used to compare different groups of respondents.
One-way analysis of variance was used to compare the mobility of four groups ( Normal , Obesity , Sarcopenia and Sarcopenic Obesity ) .
One-way ANOVA and Tukey's tests were applied for data analysis.
One-way ANOVA were calculated for the means of individual color coordinates ( L , a , b , c and h ) .
One-way ANOVA with Tukey's post-hoc showed a significant difference between groups ( p < @number@ ) .
One way in which to educate future health care team members about team dynamics is to have them learn through active participation on a team.
One way is to offer a geriatrics clerkship as an option for the fulfillment of a medical school's internal medicine rotation requirement.
One-way repeated measures analysis of variance indicated a significant difference for 25OH vitamin D variation ( p = @number@ ) among the three groups.
One way to improve the test's sensitivity and specificity is to reduce the variability of the normative data.
One week following AF64A administration the rats were evaluated for spatial memory , neuron density , acetylcholinesterase activity , and hippocampal lipid peroxidation products.
One week later a phone survey was completed that tapped further reaction to the content and behavior changes.
One-week test-retest reliability of the vSPPB was examined in @number@ participants.
One well-studied model of cognitive motor function involves engagement of action selection ( AS ) processes.
One would thus expect macrophages to belong to the \ "good guys \ " that help to protect our body against dangers such as cancer.
On ex vivo infection of murine skin , we observed efficient invasion only via the basal epidermal layer when the dermis was removed.
One-year all-cause mortality in patients who received their first diagnosis of HF in hospital was analysed using Kaplan-Meier method and Cox proportional hazard model.
One year and @number@ months after the 1st visit , the nodule increased in size from @number@ to @number@ mm.
One-year fall incidences were monitored.
One-year mortality and nursing home admission were analysed using a Cox model , with matching on the propensity to use anticholinergic drugs.
One-year mortality rates currently range from @percent@ to @percent@ , and care for these patients represents a major global economic burden.
One-year mortality reached @number@ % and 3-month readmission was of @number@ %.
One-year mortality was higher among the undernourished patients , followed by patients at risk for undernutrition.
One year of education increases the memory score approximately four decades later by about @number@ which amounts to @number@ % of a standard deviation.
One year of exercise training had little effect on cardiac compliance.
One-year retrospective fall rates were obtained at initial assessment and prospective falls were monitored by monthly calendar.
On firm support , sway path was higher in MCC than in CC both in EO and EC conditions ( p < @number@ ) .
On fMRI , subjects with severe WMH demonstrated excess activation in the pre-supplementary motor area ( SMA ) , frontal , and occipital regions.
On further analysis CAB also distinguished between MCI of different severities.
On future depression screening or diagnostic instruments , consideration should be given to excluding depression items overlapping with PD manifestations.
Ongoing and future clinical trials , specifically designed for frail patients , will hopefully define frailty-directed treatment selection.
Ongoing bone loss was linearly related to arterialized HCO3 , even after adjustment for age and renal function.
Ongoing clinical trials testing mTOR-targeted treatments number in the hundreds and underscore its therapeutic potential.
Ongoing inflammation in double-cytokine knockout CAPS mice implicated a role for caspase-1-mediated pyroptosis and confirmed that CAPS is inflammasome dependent.
Ongoing issues include the need for a better understanding of the in vivo complexity of PI3K regulation and cellular functions.
Ongoing multidisciplinary studies are needed to understand the whole spectrum and significance of tau pathologies.
Ongoing phase-II trials are addressing these issues.
Ongoing research has identified many limitations about the sensitivity of standard diagnostic procedures in detecting early-stage tumors and precancerous changes.
Ongoing social work education is needed to meet the burgeoning needs of the geriatric population.
Ongoing stress had stronger impacts than past stress.
Ongoing studies are directed at uncovering the physiological function of JHY and its role in CSF homeostasis.
Ongoing studies should clarify the potential effect of HRT on this relationship.
Ongoing studies will determine how these SUMO-regulated functions in neurons and glial cells may be impacted by Aβ and AD pathology.
Ongoing viral replication is associated with a higher risk of developing HF.
Ongoing work is focused on identifying whether such microstructural differences play a role in the higher prevalence of glaucoma in African American populations.
On half of the trials , this cue display also contained a salient-but-irrelevant abrupt onset.
ONH listeners performed similarly to YNH listeners for most stimuli , but performed more poorly for the shortest CO stimuli.
On indicators of biological age various age-dependent geroprophylactics effect of gas therapy was established.
On indicators of resistance of erythrocytes various safety of used modes was found.
On intradermal skin test , allergic reaction to hyaluronidase were confirmed.
On in vivo imaging , the mean cortical distribution volume ratio ranged from @number@ to @number@
On its way to the VSMCs NO may be prematurely degraded by reactive oxygen species.
On layer-based analysis , the magnitude of longitudinal strain increased from epicardium to endocardium across all age groups.
( Online access : @url@
Online health information has the potential to significantly impact public health , especially as the population gets older and the prevalence of dementia increases.
Online interventions increasingly target lifestyle risk factors to promote healthy aging.
Online modules were developed.
Online movement adjustments are crucial for daily life.
On-line questionnaires measured self-perceived mental and physical health at baseline and coping and work ability at follow-up.
Online social media is widespread , easily accessible and attracts a global audience with a widening demographic.
Online tools have been upgraded for a more flexible array data visualization , including options for processing user provided , non-public data sets.
On logistic regression , RBC age was not associated with the development of KDIGO stage @number@ AKI.
Only 20-meter walking speed and resting heart rate retained prognostic value for HF.
Only ~20% of respondents < @number@ years old met the criteria for aerobic endurance.
Only 21 / 670 coding SNPs , mostly epigenetic , reported in @number@ T2D-related genes , were found to be prominent coding synonymous.
Only 9-year olds showed significant costs in the cognitive task.
Only about @number@ percent of the schools offer a continuing education course in geriatrics at any one time.
Only about one fifth of respondents admitted that they were encouraged to further their education.
Only about one in five adults with hearing loss wears a hearing aid , leaving many vulnerable to poor communication with healthcare providers.
Only ACHD patients completed an illness perception inventory.
Only adults exhibited both category selectivity and individual-level adaptation bilaterally for faces in the FG and for houses in the PPA.
Only a few data are available on kidney transplantation waiting list patients.
Only a few level @number@ and @number@ studies for the respiratory system were found.
Only a few moderately significant associations were found except for escape-avoidance coping strategies , which were significantly associated with lower participation and quality of life.
Only a few of the numerous recommendations can be summarized here.
Only a few patients developed postoperative protein deficiency , and fat-soluble vitamin deficiencies were easily managed with oral supplementation.
Only a few ( @percent@ ) had sought treatment within @number@ month of appearance of symptoms.
Only a few single cells survive treatment and regain their self-repopulating capacity.
Only a few studies deal with non sinusoidal ELF-MF , including pulsed magnetic field ( PMF ) , which are produced by several devices.
Only a few studies have analyzed the role of SDC1 in mesenchymal tumor pathogenesis.
Only a few studies have been able to longitudinally report on factors that are associated with changes in telomere length in an aging population.
Only a few studies have examined age-predictive DNA patterns in saliva , which is one of the most frequently-encountered body fluids at crime scenes.
Only a few studies have examined the effect of personality traits on survival , such as optimism.
Only a few studies have investigated the prevalence and clinical characteristics of patients with PD in LTC facilities.
Only after @number@ years of age did we observe an advantage for the egocentric view , as previously reported for adults.
Only age emerged as a significant predictor of depressive symptoms over @number@ years.
Only age was predictive of edentulism among older adults with ID.
Only a greater amount in SVF cell number and ASC proliferative rate were found.
Only a handful of cross-sectional investigations have linked high iron content in various brain regions and poor performance on assorted cognitive tests.
Only alcohol use and no urinary incontinence were predictors unique to women and men , respectively.
Only alcohol use increased the risk of cognitive decline , regardless of AD pathology.
Only a limited number of large-scale association studies for AHL have been undertaken in humans , to date.
Only a limited number of multifactorial , long-term prospective studies have been performed on risk factors for falls in the general elderly population.
Only a minority of those who receive treatment for the condition have adequate blood pressure control.
Only a minor part of this association was explained by increased energy intake , which follows an increased protein intake.
Only amnestic mild cognitive impairment and mild Alzheimer's disease underwent cerebrospinal fluid analysis.
Only an increasing number of comorbid conditions was associated with poor SRH at baseline in both univariate and multivariable analysis.
Only a proportion of these increased risks among the children of older parents can be attributed to nondisjunction and chromosomal rearrangements.
Only a single end was observed after tracking @number@.5mm of combined fibril lengths , in support of fibril continuity.
Only a single gene , TREML4 , was upregulated in CAC cases in both studies.
Only a small group of supplements used by children ( @percent@ ) were based on the recommendation of a physician or other health care provider.
Only a small minority of people adhere well to all healthy living habits or even the healthiest ones.
Only a small part of the studies report on the assessment of quality of life , including the instruments used and the results.
Only a small percentage of people beyond the age of @number@ years have ' pure AD ' or ' pure vascular dementia'.
Only Central and Western Europe had gains in cardiovascular health that were sufficient to offset these demographic forces.
Only change in 400-m walk time with RT was related to exercise adherence ( correlation coefficient = -0.31 , P = .004 ) .
Only clinically negligible correlations were found between PWS and motor scores.
Only clinical trials , randomized or open label , with safety as the primary or secondary endpoint , were included.
Only controlled research papers examining the effects of FRIDs on postural control were included.
Only current smoking of long duration ( > 26 y ) was associated with the timing of the menopausal transition.
Only data obtained from healthy individuals was used.
Only DAT showed reduced ventral default mode network connectivity compared with controls.
Only DM predicted @number@ year change in disability and perceived health ( but not pain ) .
Only education was positively correlated with the Cantonese MoCA score ( r = @number@ P < @number@ ) .
Only eight genes that were modulated in both groups were significantly differently modulated.
Only empirical research papers were included.
Only faint redness was appreciated with the at optic.
Only female sex and depression risk were also associated to FoF in the final adjusted models.
Only few studies concentrated on children and adolescents.
Only few studies deal with this topic in a small number of participants.
Only four patients ( @number@ percent ) presented complications such as needing another operation.
Only FVC showed moderate control , with shared environmental factors accounting for about @percent@ of the total variance.
Only glutathione was found to protect significantly against glycation at physiological concentrations.
Only group @number@ increased MPA in continuous bouts of ≥10 minutes ( P < 0.001 ) and improved FMD% ( P = 0.001 ) .
Only half of the seafarers examined were aware of their elevated risk of photodamage due to their high UV exposure at sea.
Only having experienced any childhood adverse event was weakly but significantly negatively associated with TL.
Only if different diseases have the same syndrome , the same treatment can be used on them.
Only in bulbar-onset cases did aging seem to play a role in the pathophysiological processes underlying the loss of MyHCI + sto fibers.
Only in C4d ( + ) rejections did the presence of glomerulitis increase this association ( OR , @number@ P < @number@ ) .
Only information processing speed relevantly influenced the change in SRTn over time ( @percent@ decrease in Btime ) .
Only in premenopausal women did fat mass have a significant negative effect on bone mass.
Only in problem-solving item do these families experience more difficulty.
Only in smokers interactions are conceivable.
Only in the language comprehension task did verbal IQ correlate with lateralization , with higher verbal IQ being associated with more right-hemispheric involvement.
Only in the Northern Plains did we find that speaking some Native language at home was associated with increased odds of being a caregiver.
Only in the oldest old ( 85 + ) , the impact of a single disease was similar to that of co-occurring diseases.
Only in this way can the correct causal connections be established.
Only limited clinical follow-up data are available to evaluate duration of protection , an important consideration when developing HZ vaccination policy recommendations.
Only limited progress has been made in understanding the role of MFs in accommodation control.
Only little data are available for PP in children.
Only little is known about the age-dependent changes of wrinkles on body sites.
Only little is known when talking about the evolution of a vertebral fracture.
Only local activity differences were found between age groups.
Only loose areolar tissue comprising a remarkably well developed venous plexus connecting the middle and superior parts of the vagina with the lateral pelvic wall.
Only low activity time continued to increase when moving beyond the town.
Only MCI A + N + subjects exhibited specific changes in hippocampal connectivity and an AD-like alteration pattern.
Only mean RT could distinguish NCD-AD from NCD-vascular groups.
Only mean wrinkles score reduction at @number@ days was statistically significant ( p = @number@ ) .
Only memory performance significantly correlated with CSF levels of Aβ ( 1-42 ) , t-tau , and p-tau along the AD continuum.
Only men aged 50-65 at follow-up ( N = @number@ ) were included.
Only migrants relocated to conserve sensitive ecological areas have higher levels of depression than nonmigrants.
Only mild and moderate non-AD dementia were associated with an increased risk for falls in comparison with CHI.
Only minor species differences were found for the aging and spontaneous reactivation kinetics.
Only modularity was significantly affected by age.
Only molds that are capable to form toxins can cause intoxications.
Only MVs from senescent ECs , and from elderly subjects ' plasma , induced calcification.
Only neurointerventional procedures prevail in these cases , but well-equipped centers remain scarce.
Only @number@ cases were found where ultra-rapid metabolizers experienced severe non-lethal adverse events.
Only @number@ cognitive measure showed any sign of cortisol-related impairment.
Only @number@ intervention was found to have an effect on hospitalizations.
Only @number@ loci ( SLC2A9 , ABCG2 ) showed genome-wide significant association with gout.
Only @number@ of @number@ muscle biopsies , from the @number@ patients with a missense mutation , showed slight myopathic changes.
Only @number@ of the @number@ office visits analyzed had a discussion of medication cost.
Only @number@ of the @number@ used theories or models to guide the interventions.
Only @number@ % of the participants fulfilled all three criteria.
Only @number@ of the participants with cortical SS ( @percent@ ) also had cerebral microbleeds.
Only @number@ of these patients were eligible and recruited ( @percent@ of recruitment target ) , yielding an overall recruitment rate of @percent@.
Only @number@ participant ( @percent@ ) was symptomatic from the CCM during the study period.
Only @number@ patients had almost complete recovery.
Only @number@ patients had known multiple lesions.
Only @number@ ( @percent@ ) complication of hemorrhagic pleural effusion resolved after discontinuation of intrapleural treatment.
Only @number@ per cent identified community support services.
Only @number@ percent of idiopathic ERM patients had subjective symptoms detected by the Amsler chart.
Only @number@ ( @percent@ ) patients had no solar elastosis.
Only @number@ ( @percent@ ) patients lived longer than their life expectancy.
Only @number@ RAS mutated samples ( @percent@ ) were identified.
Only @number@ SNPs ( rs116806486 , Thr→Ala ; rs6691117 , Ile→Val ) were significantly associated with an increased risk of LOAD.
Only @number@ studies analysed associated factors and a minority carried out multivariate data analysis.
Only @number@ studies described both actual and potential DIs.
Only @number@ study examined the effect of actual food intake on appearance.
Only @number@ subjects ( @percent@ ) reported not using any medication.
Only @number@ subtests of the WAIS-IV ( General Information and Block Design ) showed no significant variation due to age.
Only older patients having a caregiver were analyzed ( @percent@ , n = @number@ ) .
Only one adverse effect , facial edema , was judged \ "probably related to treatment. \ "
Only one AFF patient treated with plate and screws required surgical revision , compared with none in the TFF group.
Only one cognitive debriefing round was needed with each of the other provider groups.
Only one indicator was associated with decision authority.
Only one intervention proved ineffective.
Only one measure , 2-back , showed a speed-accuracy trade-off in the dual task.
Only one new individual with the p.Ala53Glu mutation was identified , confirming that this mutation is a rare cause of PD in the Finnish population.
Only one non-linear association between LTL and plasma ACTH area under the curve increment was significant after adjustments for covariates and confounders.
Only one patient experienced transient elevation of serum alanine transaminase and aspartate transaminase with maximal Common Toxicity Criteria , grade @number@
Only one patient ( @percent@ ) could supply the history of aspiration on his first visit to doctor and was diagnosed definitely without delay.
Only one previous study is known that examined age trends in performance for this triathlon distance.
Only one qualitative study asked older adults about reasons for non-adherence.
Only one quarter of those with prior falls reported making changes and few were evaluated by professionals to prevent future falls.
Only one researcher ( BJ ) was aware of the group assignment performing the randomisation and the extracorporeal shock wave therapy.
Only one skull ( @percent@ ) had the frontal sinus absent.
Only one study assessed caregivers ' preparedness and showed improved posttest scores.
Only one study focused on cardiovascular events and found no statistically significant association.
Only one study ( Holsinger @number@ ) was found to be at low risk of bias on all methodological domains.
Only one study reported improved ankle evertor strength and a significant reduction in falls.
Only one study was an RCT of \ "adequate \ " methodology.
Only one subject met the criteria to be classified as high response for both creatine kinase and interleukin-6 responsiveness.
Only one tool , the Yale Food Addiction Scale ( YFAS ) has been developed to specifically assess food addiction.
Only papers which included preterm infants in their study population and specifically assessed IS were included.
Only parathyroid surgery has been demonstrated to cure PHPT and complications related , showing similar outcome between older and younger patients.
Only parent-reported Total PedsQL score predicted higher subsequent BMI , though this effect was small.
Only participants ' perception of their eating habits demonstrated a significant , positive improvement ( t24 = 2.1 , P < 0.05 ) .
Only patellofemoral Outerbridge cartilage grade was associated with worse outcome.
Only patient's age had a positive prognostic association with unrecognized COPD ( OR = 1.16 ; @percent@ CI @number@.01- @number@ p < 0.01 ) .
Only patients up to 60-years have been included in these trials.
Only PD and HbA1c sustained an independent significant impact.
Only peak serum creatinine before biopsy and the use of immunosuppression influenced progression to ESRD.
Only peer reviewed research articles from @number@ to @number@ were reviewed.
Only @percent@ and @percent@ of youth in the highest and lowest PA quintiles , respectively , remained in these quintiles as adults.
Only @percent@ checked their feet every day , @percent@ revealed symptoms of neuropathy and @percent@ used inadequate footwear on at least one foot.
Only @percent@ described having a negative experience.
Only @percent@ had contractures , while @percent@ had palmar fibromatosis without contracture.
Only @percent@ named at least @number@ correct risk factor for stroke.
Only @percent@ of all invited elderly people accepted the invitation , with old age and poor health being the primary reasons for non-participation.
Only @percent@ of GPs always / often used the Irish Road Safety Authority handbook when assessing FTD with @percent@ not aware of its existence.
Only @percent@ of graded rooms had adequate lighting.
Only @percent@ of HABC patients received an order for neuroleptics and only @percent@ had simultaneous orders for both definite anticholinergic and anti-dementia drugs.
Only @percent@ of hearing impaired participants owned hearing aids and @percent@ reported low use ( < 1 hr / day ) .
Only @percent@ of irradiated women with a lower GI diagnosis and less than @percent@ of irradiated women with a bladder diagnosis , required hospitalization.
Only @percent@ of measures had population-specific reliability and @percent@ had population-specific validity.
Only @percent@ of men reporting ED were concerned about it.
Only @percent@ of older people considered their health as excellent or good in comparison with others at this age.
Only @percent@ of patients in @number@ would consider eating in a day / dining room compared with @percent@ in @number@
Only @percent@ of patients reported using a sleep medication at least weekly.
Only @percent@ of patients stated that continued back / leg pain limited their play.
Only @percent@ of patients were in the same risk category for both systems.
Only @percent@ of patients with psychiatric problems reported recent psychotropic use.
Only @percent@ of regular NSAID users ( i.e. those prescribed NSAIDs for > 180 days ) were prescribed any gastroprotective medication.
Only @percent@ of the children who participated in all three surveys reported BP each time and @percent@ of these always reported no pain.
Only @percent@ of the consultation recommendations were eventually implemented.
Only @percent@ of the depressed COPD patients had consulted psychiatrists in the past three months.
Only @percent@ of the entire studied population had GFR < 60 mL / min / 1.73m2 without simultaneous diseases or kidney damage.
Only @percent@ of the FTD clinical diagnosis had pathological CSF levels.
Only @percent@ of the iH-HIFKO mice developed cholesterol gallstones.
Only @percent@ of the participants could name @number@ close network members , and @percent@ could name @number@ members.
Only @percent@ of the patients met the daily adequate intake for vitamin D and @percent@ met the daily adequate intake for calcium.
Only @percent@ of the patients with fat-free mass depletion was detected when using the criteria BMI < 10 percentile.
Only @percent@ of the schools taught about elder abuse.
Only @percent@ of these patients who were referred out of our ED returned to be seen in our ED within the three-month interval.
Only @percent@ of the subjects were able to perform all four tests correctly.
Only @percent@ of the US population is clinically deficient.
Only @percent@ of the women were professionally active and @percent@ were unemployed.
Only @percent@ of those with a psychiatric diagnosis were prescribed medication from the appropriate class.
Only @percent@ of US patients believed depression means a person is weak , compared to @percent@ ( Korea ) and @percent@ ( Russia ) .
Only @percent@ , @percent@ , @percent@ , and @percent@ met the guidelines for vitamin D , sodium , calcium , and saturated fat intake.
Only @percent@ received step @number@ analgesics ; this rate remained low even in patients with severe pain.
Only @percent@ reported exercises were made more difficult as they improved.
Only @percent@ reported having a succession plan.
Only @percent@ were taking a vitamin supplement.
Only @percent@ were treated for secondary prevention after discharge.
Only @percent@ women with POP were nulliparous.
Only principal discharge diagnoses were examined to ascertain cardiovascular events of interest.
Only randomised controlled trials examining the effects of CMI for older people were included.
Only randomized clinical trials or controlled clinical trials assessing the effectiveness of botanical extracts in reducing wrinkling and aging of the skin were included.
Only randomized controlled trial , cohort , and observational studies evaluating the effect of VGs on physical rehabilitation were included in the review.
Only rare cytoplasmic phosphorylated and ubiquitinated TDP-43 inclusions were seen in hTDP-43-ΔNLS mice , suggesting that cytoplasmic inclusions were not required to induce neuronal death.
Only recently has LTL shortening within individuals been analyzed in longitudinal studies.
Only recently , however , have studies begun exploring the effect of lifestyle interventions on the mediation of inflammation in individuals with MetS.
Only recently , however , more attention has been paid to possible transgenerational effects of stress.
Only recipients sharing oocytes with either the donor or another recipient were included.
Only relatively brief but arousing events seem to be time stamped at SCN level.
Only sexual subscale scores were significantly inversely associated with free or bioavailable testosterone level.
Only sildenafil @number@ mg qd improved nocturia significantly ( versus placebo , p = @number@ ) .
Only small changes of methylation of DNA promoter regions were observed.
Only speed of processing showed an aging-related decline , while other cognitive domains were relatively maintained.
Only studies published in peer-reviewed journals written in English language were considered.
Only studies that conducted colonoscopy in all subjects were included.
Only studies using the subsequent memory paradigm were included.
Only TE and HE displayed significant improvements ( P < @number@ ) in knee extensor strength , and only HE had faster gait speed.
Only the cohort studies demonstrated improvement of cognitive performance after discontinuation of anticholinergic medicines.
Only the creatinine level correlated with subtelomeric methylation , but not with telomeric length.
Only the distribution between small and large detected objects ( microrelief features and wrinkles , respectively ) is modified.
Only the first component score was positively correlated with an increased pediatrician workforce per @number@ of the population under the age of @number@ years.
Only the global mental dimension of the SF-36 was sensitive to exergame practice.
Only the gluteus medius was significantly associated with the LSA score ( r = @number@ p < @number@ ) in elderly women.
Only the IDF definition had a significant association with AD ( OR = @number@ 95%CI , @number@.202-2.857 ) .
Only the KY group showed significant improvement in depressive symptoms and resilience at week @number@
Only the latter region showed accelerated GM volume loss with increasing age.
Only the MSC-injected G3 rats had an organized enthesis with columnar chondrocytes as in a native enthesis @number@ days after surgery.
Only then , it will be possible to advance the understanding of how vascular brain changes affect cognition.
Only the oHC group had a significant association between mean cortical florbetapir SUVRs and age.
Only the older group demonstrated a statistically significant relationship between the story measures.
Only the physical training group showed improved concentration @number@ months later.
Only the results of the key informant interviews are reported here.
Only the variable \ "exposure to political violence \ " was significantly associated with the mental health component ( p = @number@ ) .
Only the young group showed significant improvement in anger ( P = @number@ ) and vigor ( P = @number@ ) .
Only they were treated with alfa blockers while other patients received no therapy.
Only the μTBS of Adper Single Bond @number@ dropped significantly after @number@ months among the control groups.
Only this association was mediated by an underlying association with vitamin B12 and folate levels.
Only those @number@ and older experienced a significant decline over the next @number@ years.
Only those trials in which there was a match between the subject's response and the IAPS rating were included in the analyses.
Only those who reported having one or more ADL disabilities were included.
Only three heat wave response plans that were analyzed included specific guidance for aged care facilities.
Only twenty-three studies had faithfully applied ISO standard.
Only two genes expressed in lymphoblastoid cell lines showed significant changes with age.
Only two of direct nanohybrid resin composites performed better after two aging methods.
Only two of these loci harbor genes in a pathway known to affect BP ( CYP17A1 and NPPA / NPPB ) .
Only two other outcomes were reported in two or more of the studies ( step test and physiological profile assessment ) .
Only two patients experienced small hematomas needing evacuation.
Only two patients required additional procedures.
Only two significant variables were associated with successful aging neither of which are easily remediable.
Only two studies were identified that had been designed specifically for and examined exclusively in people with dementia or cognitive impairment.
Only urinary epinephrine differed between fasting and overfeeding diets ( Δ = @number@ ± @number@ µg / 24h ; P < @number@ ) .
Only vaccination with the combined regimen of adjuvant and chemokine provided 80-100% protection against the development of bloodstream infection.
Only visual artists ( LE50 : @date@ @number@ ) had a lower life expectancy at age @number@ compared to the elite at that time.
Only when glomerulosclerosis and arteriosclerosis exceed that expected for age is there an increase in single-nephron GFR.
Only young adults , however , showed significant slowing to the semantically related lure items.
Only younger age was associated with improvement in frail women.
On magnetic resonance images , we measured volumes of brain regions relevant to spatial navigation.
On medical level , the etiology of the infertility must be taken into account.
On medication , as the response to drugs is different to that in younger patients , side effects easily appear in the elderly.
On multiple linear regression , DHT and 3β-diol remained independent predictors for TIPSS and fT for tPSA.
On multivariable analysis , only ' lack of energy ' predicted a TT level of < 400 ng / dL.
On multivariate analysis age was associated with changes in sexual function and bother from baseline through @number@ years ( each p < 0.01 ) .
On multivariate analysis , an age-dependent increase in LVSIdia was confirmed.
On multivariate analysis , erectile function remained a significant predictor of depression , beta = -0.10 , P < 0.05.
On multivariate analysis , however , only serum DHT level and DHT / TT ratio remained significant.
On multivariate analysis , there were associations of total IgE level and mite- and cedar-specific IgE levels with both age and birth cohort.
On multivariate analysis using the HRV index , WISW was independently related to height and the HRV index.
On multivariate logistic regression analysis , these variables were also significant predictors of high-risk CRP levels.
On neuropathologic examination , @number@ persons had Lewy bodies ( @number@ neocortical , @number@ limbic , and @number@ nigral ) .
On @number@.0T MRI , four zones could be recognized at @number@ weeks GA.
On @number@ days , @number@ younger and @number@ older adults reported stressors , intrusive thoughts , and negative affect.
On occasions after which the grown child moved out of the family home , anxiety was lower.
On occasions when behavior problems were higher , depressive symptoms and anxiety were higher.
On occasions when intraindividual variability was high , participants ' cognitive performance was correspondingly low.
On one hand , it is overexpressed in cancer cells and is required for self-renewal of stem cells.
On organismal level , geroconversion leads to age-related diseases and death.
On passive blocks subjects rested and ignored the sounds.
On PiB-PET scans , the patient with PT21 had lower PiB standard uptake values than controls with typical DS or sporadic AD.
On preoperative examination , difficulty with endotracheal intubation was predicted in @number@ of @number@ patients.
On randomized days , the protocol was repeated without or with fan use.
On randomly selected trials , HTcoupling was achieved by using a collar.
On reinterpreting some data of studies concerning Bruch's membrane , changes observed at different age points seem more likely to be nonlinear.
On-road driving performance was evaluated by instructors during a @number@ minute validated open-road circuit.
Onset could only be extracted in @number@ articles ( @percent@ ) : mean onset was @number@.09±2.38 days.
Onset endpoint was categorical ( physician assessed : days @number@ @number@ @number@ @number@ and @number@ subject : 14-day diary ) .
Onset of activity is typically seen within @number@ days of injection , but has also been recorded within @number@ hours with abobotulinumtoxinA.
Onset of dementia ( N = @number@ ) was recorded at serial assessments @number@ @number@ and @number@ years after baseline.
Onset of hypertension in mid-adulthood predicted @percent@ higher dementia risk in women ( @percent@ CI @number@ @date@ ) compared to stable normotensive.
Onset of neurodegenerative disorders , including Huntington's disease , is strongly influenced by aging.
Onset settings were not independently associated with outcomes.
On standard memory tests , these two aspects of memory function can be measured by examining the items forgotten or acquired across multiple learning trials.
Ontario LTC homes face numerous challenges in the planning of menus for residents , regardless of a home's size , location , or profit status.
On the background of aging population an increase of patients suffering from stroke has to be expected during the next years and decades.
On the base of our investigation we can make resume about functional role of Hassall corpuscles.
On the base of ROC data , the cut-off values with best accuracy to predict fractures for both methods were established.
On the basis of analysis of @number@ scores , construct and concurrent validity were established.
On the basis of classic Snellen acuity , we simply cannot predict threshold skill levels of any one individual ( s ) .
On the basis of current utilization patterns , demand for primary care providers is expected to grow more rapidly than physician supply.
On the basis of data presented in the literature , the treatment gap in our study population was estimated to vary from @percent@ to @percent@.
On the basis of full-text analysis , only four studies met the inclusion criteria.
On the basis of history , comorbidities ( osteoarthritis , diabetes , and hypertension ) were recorded.
On the basis of our findings , we propose in vivo rating criteria for the detection of intracortical CMIs.
On the basis of spirometry performed on the day of admittance to the hospital , the patients were divided into three groups.
On the basis of such points , a treatment algorithm is proposed.
On the basis of the 15-items Geriatric Depression Scale ( GDS ) , score > 5 identified subjects with depressive symptoms.
On the basis of the EGGs of elderly individuals , the effect of hot stupe application on the epigastrium was also evaluated.
On the basis of the histomorphological changes , peeling depth was classified as superficial , superficial-partial , deep-partial and full thickness chemical burn.
On the basis of the longitudinal changes subjects were stratified as being stable , moderate or improved.
On the basis of the metabonomics data , selected underlying processes were further investigated using proteomic and transcriptomic approaches.
On the basis of the past @number@ years of experience , we made several changes in the clinical criteria for the diagnosis.
On the basis of the results , both the attenuation coefficient and the speed of sound follow a three-phase age-related pattern.
On the basis of the results of this study , @percent@ nifedipine cream seems to be effective in reducing the depth of periocular wrinkles.
On the basis of these considerations , the authors developed a metric to rank families for selection into a family study of longevity.
On the basis of these factors , patients were divided into favorable- , intermediate- , and poor-risk groups according to the number of factors present.
On the basis of these findings , the authors recommend a revision of the concept definitions as well as of the items.
On the basis of these results , patients and their physicians independently rated the importance of each problem disclosed by the assessment.
On the basis of this finding , the implantation of such devices seems justifiable , even in this age group.
On the behavioral level , linear regression analysis demonstrated that age accounted for significant variance on Stroop interference , whereas TMT-A performance did not.
On the cellular level , several recent studies revealed unexpected crosstalk of signaling pathways downstream of @date@ activation in the kidney epithelium.
On the clinical program side , state and federal governments are initiating programs to promote delivery system changes that improve the care of older adults.
On the contrary , a few studies identified a negative impact of atazanavir / ritonavir or darunavir / ritonavir on trunk fat increase.
On the contrary , between @number@ and @number@ years , LQT2 male patients had significantly longer QTc interval than LQT2 female patients.
On the contrary , few material is in our possession regarding CKD patients on conservative therapy.
On the contrary , GEB significantly decreased MMP-1 and elastase-1 mRNA levels , which were markedly induced in UVA-irradiated HDF.
On the contrary in the extraocular muscles , wild-type TTR was the main component of the amyloid with a percentage of ∼70%.
On the contrary , left ventricular diameters and volumes were below ASE reference range.
On the contrary , only young individuals showed a vigilance decrement in the Go / No-Go SART.
On the contrary , papillary carcinomas only ; showed a mild uptake.
On the contrary , PD patients showed an absence of performance modulation in response to positive and negative feedback.
On the contrary , plasma total homocysteine level did not show any significant association with whole brain volume.
On the contrary , Rb3 displayed enhancing activities on UV-B-reduced total GSH and SOD activity levels.
On the contrary sedentary animals become frail as they age.
On the contrary , sex differences in survival did not vary by location of CRC.
On the contrary , the female disability group showed more depressive symptoms than the male disability group.
On the contrary , we found correlation between ARMD and hearing ( p = @number@ ) and equilibrium impairments ( p = @number@ ) .
On the contrary , we suggest that miR-22 has not substantial impact on heart longevity as proposed recently.
On the day of starting chemotherapy , demographic data , performance status ( PS ) , and geriatric parameters were recorded.
On the DP side , the overall improvement was good to excellent at a @percent@ rate by the investigators and @percent@ by the subjects.
On the FD2 , the medians were @number@ @number@ @number@ arcsec for the whole population and @number@ @number@ and @number@ for the sub-population.
On the first @number@ postoperative days , the patients were assessed twice daily using the Confusion Assessment Method - Chinese Revision.
On the Metacognition Index , we found that 9- to 11-year-olds differed significantly from 5- to 8-year-olds on the Working Memory subscale.
On the NFL sides subjects were treated @number@ times with the 1927-nm laser at 4-week intervals.
On the one hand handling with such a vast amount of data necessitates the use of appropriate informatics tools and the establishment of a database.
On the one hand , several prospective observational studies now clearly indicate a protective effect of higher fish and DHA intake against risk of AD.
On the opposite to give false hopes may be discussed too.
On the organism's level , RNA editing plays a key role during ontogenesis and in the defense against pathogens.
On the other hand , 2-year prognosis for patients without evidence of AD pathophysiology was good.
On the other hand , administration of testosterone to hypogonadal men improved insulin sensitivity and glucose homeostasis.
On the other hand , age-separated face recognition consists of recognizing an individual given his / her age-separated images.
On the other hand , aging recipients and recipients with complications have increased.
On the other hand , apart from the other lifestyle-related diseases , the prevalence of osteoporosis also increases rapidly accompanying aging.
On the other hand , apo D expression has been correlated , in some brain regions , with normal ageing and neurodegenerative diseases.
On the other hand , APPL1 potentiates both the actions and secretion of insulin by fine-tuning the Akt activity in multiple insulin target tissues.
On the other hand , as for nutritional supplementation , it has been reported that it works for improving sarcopenia by amino acid ingestion.
On the other hand , being psychologically depressed was associated with poorer cognition among pre-Boomers.
On the other hand , beneficial effects on inflammation and pain were observed.
On the other hand , bidirectional effects of statins on oxidation and inhibition of appropriate lens epithelial cell development may promote cataractogenesis.
On the other hand , both Edaglitazone and Ciglitazone displayed an antiplatelet activity , but only Edaglitazone retained such effect at low concentrations.
On the other hand , caloric restriction is the only non-genetic mechanism that is shown to increase life span.
On the other hand , clear ASSFs could be observed only in one patient.
On the other hand , considerable evidence was found supporting a decreased visual feedback-processing efficiency and the implementation of a play-it-safe strategy in older age.
On the other hand , CSF miR-29a and miR-29b levels were significantly higher than in control subjects.
On the other hand , Cu and Mg levels in plasma remained substantially unchanged during aging.
On the other hand , CUTA overexpression ameliorated copper-induced Aβ secretion but had no effect on APP expression.
On the other hand , education level , as measured by years of formal education , produced an opposite effect on the long-term.
On the other hand , ejaculate quality appeared to be affected by ageing.
On the other hand , entorhinal-hippocampal tau pathology is an invariant feature of AD and is always associated with its development.
On the other hand , evidence for anti-oxidant supplements increasing longevity in humans is lacking.
On the other hand , evidence has been accumulating that anemia reflects poor health and increased vulnerability to poor outcomes in older persons.
On the other hand , excessive mechanical load involved in exercise and sports activities can be harmful potentially causing overuse injuries of the musculoskeletal tissues.
On the other hand , functional results after prostate cancer treatment are worse in elderly patients.
On the other hand , gait instability likely begins to increase at an accelerated rate as early as age 40-50.
On the other hand , glass is expected to be stable not only in physically but also chemically even in the presence of organic solvents.
On the other hand , glucose hypometabolism in MCI was confined to cingulate and medial temporal cortices.
On the other hand , homocysteine and cysteine levels decreased significantly ( p = @number@ p < @number@ respectively ) .
On the other hand , in people aged @number@ years and over , diastolic blood pressure remains unchanged or decreases.
On the other hand in underweight children , it was significantly greater when sized by the ideal weight.
On the other hand it has become clear that regulated protein degradation also plays a major role in neuronal plasticity and learning behavior.
On the other hand , it is downregulated during senescence and aging.
On the other hand , long TL was paradoxically associated with longer diagnosed duration of moderate CKD.
On the other hand , MN frequency did not differ significantly between the control and total study groups.
On the other hand , most of toxicities were enough manageable.
On the other hand , myofibroblast differentiation was inhibited by the reduction of sialylation , indicating that sialylation is important for myofibroblast differentiation.
On the other hand , non-tuberculous mycobacteriosis ( NTM ) is increasing recently , which bothers many physicians or pulmonologists.
On the other hand , no significant correlation was observed between the magnitudes of visual speech effects and psychophysical responses.
On the other hand , obesity was related to lower Q10 and higher MDA levels in plasma affecting women more significantly.
On the other hand , older adults who are satisfied with their life may be more able to develop and maintain a wider social network.
On the other hand , once AD is clinically evident , supplementation trials demonstrate essentially no benefit of DHA in AD.
On the other hand , over-estimation of chronological age in bone marrow failure syndromes is indicative for exhaustion of the hematopoietic cell pool.
On the other hand , overexpression of autophagy in the heart and arteries can produce detrimental effects.
On the other hand , p53 induces the apoptosis of cardiomyocytes in the failing heart.
On the other hand , peripheral cortisol levels declined with aging within the obese , but not in the non-obese groups.
On the other hand , physical exercise counteracts the occurrence of NCDs , potentially acting on the same pathways.
On the other hand , population aging and the associated rise in the incidence of chronic disease is increasing the demand for long-term care.
On the other hand , prednisolone at greater than @number@ mg / day was associated with serious infections in both biologics-treated and non-biologics-treated patients.
On the other hand , pregnancy and breastfeeding affect bone metabolism.
On the other hand , RE could lead to acute cardiovascular risks prompted mainly by intense blood pressure elevations and cardiac autonomic imbalance.
On the other hand , reduced effectiveness of conventional doses of cardiovascular drugs , such as diuretics and β-blockers , has been observed.
On the other hand , regression models were less predictive ( @number@.17≤R ( @number@ ) ≤0.73 ) for the @number@ and @percent@ exercises.
On the other hand , regular exercise and proper nutrition containing some antioxidant can improve the muscle function by a reduction of excessive oxidative stress.
On the other hand , respiratory system homogeneity decreases during the ageing process.
On the other hand , selected drugs may slow or delay functional decline in older people.
On the other hand , smoking status and aging did not seem to change the association between genotypes and PCa risk.
On the other hand , some biological factors , namely oxidative stress , inflammation , estrogen and other hormone deficiency are predictors of these phenomena.
On the other hand , statistically significant effect of XbaI c454-351A > G SNP on serum TG and TL levels.
On the other hand , stem cells play crucial roles in tissue repair and homeostasis.
On the other hand , subclinical zinc deficiency is common in the old who might be more susceptible to depression.
On the other hand , substitution of information and interference due to representational overlap were not affected by age.
On the other hand , surgical treatment is expected of otolaryngologists in over half in the hospital group.
On the other hand , telomere length was shorter in aortic tissues which presented atherosclerotic lesions compared to corresponding tissues without atherosclerotic lesions.
On the other hand , the association between telomere length and mortality is poor.
On the other hand , the benefits on health of a diet rich in fruit and vegetables are well described.
On the other hand , the demographic circumstances drive scholars as well as politicians to reflect on ageing dynamics.
On the other hand , the diseases associated with sensitive genes are apparently nonlethal like psych and chemical dependency diseases.
On the other hand , the effect of androgen on women's health has not been elucidated.
On the other hand , the expression of TIMP-1 and tropoelastin was increased in fibroblasts treated with the extract of the mycelium of T. matsutake.
On the other hand , the NP effect was only reliable in the younger group , the older group not showing NP suppression.
On the other hand , the orbital and pyriform widths did not show statistically significant changes with aging.
On the other hand , the poor responders showed significant changes in these variables compared with matched pretreatment values.
On the other hand , the presence of OP did not seem to have any effect on cartilage thickness measurements.
On the other hand , the presence of tau , MAP2 , and NeuN in Aβ granules suggests a neuronal origin.
On the other hand , the prevalence and severity of periodontal disease has been found to grow with increasing age.
On the other hand , the QRS duration tended to increase progressively with age , and some patients had an abnormally prolonged QRS duration.
On the other hand , therapeutic upregulation of SIRT1 might provide opportunities for the amelioration of Alzheimer's-disease-type neuropathology through inhibition of amyloidogenesis.
On the other hand , there existed relatively high compatibility between its hydrophobic group and the biopolymer matrix.
On the other hand the results illustrate that in organisational respects the situation is highly heterogeneous and unregulated.
On the other hand there was a significant difference among the samples in ultimate strength values.
On the other hand , there was no significant correlation between the salivary concentration of glutamic acid or histidine and age.
On the other hand , the sample size ( n = @number@ ) may preclude subgroup analyses in such a heterogeneous sample.
On the other hand , the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is suggested.
On the other hand , the transient receptor potential vanilloid @number@ channel is a nonselective cation channel that senses various noxious chemical and thermal stimuli.
On the other hand , the younger and affluent populations used the web-based PHR much easily and efficiently compared to the older and low-income group.
On the other hand , they were impaired in suppressing reflexive saccades ( saccades to cue ) .
On the other hand , TRPV-1 antagonist pretreatment reduced heat-induced MMP-1 in fibroblasts but not their SSR-treated counterparts.
On the other hand , we have studied microglial phagocytic ability for a compensatory pathologic reaction to Aβ accumulation.
On the other hand , we have very limited data on the relationship between systolic and diastolic blood pressure and stroke prevention.
On the other hand , young female and young male cells had similar action potentials under control conditions.
On the other site , old people have dysregulated microRNA levels , this reducing their potential for plastic phenotypes.
On the positive side , individuals without BP at a previous survey were likely to remain pain free at the subsequent survey.
On the primary outcome measure , no difference was found in treatment effect between the sertraline and venlafaxine group.
On the relationship between longevity and telemedicine , the society begins to request telehealth when the elderly proportion is > 2.06%.
On-the-road driving tasks ( under single- and dual-task conditions ) included measures of simple and choice reaction time , movement time , and response time.
On the same day , we assessed grip strength with a handheld dynamometer.
On the transition to HUT , HR increased only for -55° condition , but stroke volume and cardiac output transiently increased for -25° and -55°.
On the walking task , participants displayed smaller walking speed errors at comfortable walking speeds compared with slower of faster speeds.
On the way to solve this problem , it is inextricable to measure QOL for older people accurately at onset.
On the whole , our data suggest that PhS1P displays a synergistic anti-aging effect together with EGF , both in vitro and in vivo.
On the whole , our study suggests that OPC plays an important role in controlling the antioxidant response of A549 cells via the Nrf2-ARE pathway.
On this account , the expression of CASP3 gene was evaluated in cultures of fibroblasts of DS and normal subjects by flow cytometry.
On this account , we established a new sandwich SELENOP-ELISA and calibrated against a standard reference material ( SRM1950 ) .
On this basis , distinct tables of normative data were produced for women and men.
On this basis , rs55710688 was selected for an in vitro translation experiment since it is located in the Kozak sequence of WNT16a.
On top of this situation , the deleterious effects of the inflammatory processes induced by the tumour are superimposed.
On univariate analysis , erectile function and depression were associated , r = -0.12 , P < 0.05.
On univariate analysis WHt ratio was more strongly correlated with TT and cFT than either WC or BMI.
On visual rating of SH severity , AD and NC groups were subdivided into high-SH and low-SH subgroups.
On weekdays , EW initiated activity earlier than homemakers but not on weekends.
On weekends , both groups had less MVPA than weekdays.
On whether OA influences bone loss or osteoporotic fractures , differences are observed according to the affected joints.
Onychomycosis is an often overlooked and / or undertreated disease.
Oocyte number and quality decrease with advancing age.
Oocytes were collected after superovulation , and their viability were compared using parthenogenetic activation.
Opacifiers , oil pigments and inorganic colourants may have a protective effect on colour stability of prostheses.
Open and selective coding techniques were used to analyse the interactively derived data.
Open-angle glaucoma is an optic neuropathy that has a multifarious aetiological profile.
Open-angle glaucoma , open-angle glaucoma suspect , primary angle-closure glaucoma , primary angle closure , and primary angle-closure suspect were defined by published criteria.
Open , axial , and selective coding and constant comparison analysis were used.
Open Door is a brief psychosocial intervention to improve engagement in mental health treatment by collaboratively addressing the individual level barriers to care.
Open-ended answers were coded for recurring themes.
Open-ended comments from both surrogates and clinicians were uniformly positive.
Open referral policies and nurse-led services may overcome some of the barriers to early diagnosis that are currently experienced.
Open repair for chronic type-B dissection can be performed safely but is a relatively morbid operation.
Open repair ( OR ) was performed in those patients with hostile proximal neck anatomy and / or severe iliac tortuosity.
Opera singers , \ "People artists \ "-men live longer @number@ yrs , and women-by @number@ yrs longer than their no-honored colleagues.
Operating time , duration of catheterization , and BMI did not determine a significant decrease of the IIEF-5 score after TURP.
Operating time was @number@ ± @number@ min , compared in the three groups , p > @number@
Operation time , intraoperative blood loss , incision status and complications were recorded.
Operative markings , liposuction , and the excisional technique are presented with intraoperative video footage.
Operative mortality decreased and many patients ( re ) entered school ; emphasis on neuropsychological sequelae , IQ and academic performance.
Operative mortality was analyzed using inverse probability-weighted estimators with propensity score adjustment.
Operative time and catheter removal time differed significantly between the three groups ( P = 0.001 ) .
OP exposures at residential addresses were estimated with a geographic information system ( GIS ) based exposure assessment tool.
Ophthalmic Physiol Opt @number@ 8 : 153-164 ) .
Ophthalmic surgery would a surgical practice with fewer complications compared to other types of surgery.
[ Ophthalmic Surg Lasers Imaging Retina.
Ophthalmologists examined participants with additional instruments like bio-microscope , digital camera , auto-perimeter and auto-refractor in a mobile van.
Opiate dose and / or duration were included in a further @number@ terms.
Opiate drugs ( mostly pain killers ) are the most frequently implicated in drug addiction after benzodiazepines ( BZD ) in the aged.
Opiates relieve breathlessness , and referral to a multidisciplinary breathlessness service is an option for those with intractable symptoms.
Opinions differed about what should happen should residents lose capacity during a research study.
Opinions on the shortage in village doctors and the potentially effective approaches to addressing the problem were sought.
Opinions oscillated between optimism / awareness of physical sequelae of radiotherapy.
Opioid analgesics were used daily by @percent@ of participants.
Opioid receptors play pivotal roles in the regulation of learning and cognition.
Opioids are effective analgesics for the management of moderate to severe cancer pain.
Opioid switching was less frequently present in the older patients ( p < 0.005 ) .
OP pesticide poisoning is a serious condition that needs rapid diagnosis and treatment.
Opportunistic fungal infections are usually seen in immunocompromised patients.
Opportunities exist for treatment modification within this population to achieve tighter glycemic control.
Opportunities exist to address the use of antiplatelet agents among patients without major indications to improve patient outcomes.
Opportunities for hospice and palliative social workers to demonstrate leadership in IPE and IPP are presented in this article.
Opposite results were obtained in the presence of glutamine instead of glucose.
OPP significantly decreased from baseline after @number@ hours of steep Trendelenburg positioning ( p = @number@ ) .
Optical blur degrades visual acuity and stereoacuity similarly under white-light conditions , indicating that both functions are affected proportionally by optical defocus.
Optical coherence microscopy ( OCM ) has been demonstrated to be capable of imaging small animal hearts with high spatial resolution and ultrahigh imaging speed.
Optical coherence tomography ( OCT ) imaging demonstrated that all retinal layers were present in the eyes of both DJ-1 KO groups.
Optical coherence tomography ( OCT ) is a potent tool for the detection of MS-related retinal neurodegeneration.
Optical coherence tomography was also associated with higher self-rated competency , knowledge and perceived relevance to practice than other modalities.
Optical coherence tomography was used to measure macular thickness and to evaluate XLRS-related structural changes.
Optic atrophy @number@ ( OPA1 ) is an essential GTPase protein for both mitochondrial inner membrane ( IM ) fusion and cristae morphology.
Optic flow provides visual self-motion information and is shown to modulate gait and provoke postural reactions.
Opticians noted the presenting and the best corrected vision of participants from @number@ clusters.
Optimal and tailored interventions can be further applied to avoid potential adverse events in this population.
Optimal BMI for lowest mortality became gradually higher with worsening diabetes for each sex and each age-group.
Optimal BMI ( kg / m CONCLUSIONS : U-curve relationships existed regardless of diabetes status.
Optimal care must be delivered to minimize the time spent in the acute care setting.
Optimal cellular function and therefore organism's survival is determined by the sensitive and accurate convergence of energy and nutrient abundance to cell growth and division.
Optimal cognitive and emotional function is vital to independence , productivity , and quality of life.
Optimal control of blood pressure in women may reduce the incidence of PD.
Optimal cutoff for a diagnosis of probable AD was a MoCA score ≤14.
Optimal cutoff for the discrimination of probable cognitive impairment was a MoCA score ≤17 ( associated to MMSE cutoff of @number@ ) .
Optimal cut-off points for each subtest are suggested.
Optimal cutoff values determined by ROC curve analysis improved the prediction of vascular obstruction and hemorrhage.
Optimal CVDRF profile was associated with the lowest adjusted AMI rates.
Optimal intake is required to maintain homeostasis and to increase cell protection.
Optimal levels of membrane fluidity are essential for numerous cell functions including cell growth , solute transport and signal transduction.
Optimal management of BC in the elderly is a real challenge and requires a multidisciplinary approach , mainly because the elderly population is heterogeneous.
Optimal management of perioperative pain using opioid-sparing multimodal analgesic techniques and preventing PONV using prophylactic antiemetics are key elements for achieving enhanced recovery after surgery.
Optimal management would be expected to help to reduce illness burden , reduce mortality and hospitalizations , and improve function and quality of life.
Optimal micronutrient status would moderate the deterioration in brain integrity.
Optimal nutrient status is challenging particularly when a substantial proportion of nutrient intake is from non-natural sources.
Optimal referral ASQ-3 score at @number@ months to achieve @percent@ NPV was @number@
Optimal repair of skeletal tissue is necessary in all varieties of elective and reparative orthopedic surgical treatments.
Optimal repair of skeletal tissues is necessary for successful outcomes of these many different orthopedic surgical treatments.
Optimal sensitivity and specificity of Aβ measurements were determined by ROC curve analysis.
Optimal serum triglyceride levels were seen in @percent@ subjects while optimal levels of HDL cholesterol were seen in @percent@ subjects only.
Optimal treatment of hypertension is important to reduce cardiovascular disease.
Optimal use of blood components requires even more attention.
Optimisation of the model is much needed for the study of new anti-malarial drugs , drug combinations , and candidate vaccines.
Optimised primary and secondary prevention and treatment is urgently needed to counter this growing trend.
Optimising PDT treatment needs to optimize pain control.
Optimism and life satisfaction are consistently linked with socioeconomic advantage and may be one conduit by which social disparities influence health.
Optimism remained uniquely related to all health outcomes , except physical activity ( which was more highly related to conscientiousness and goal adjustment ) .
Optimistic women were still at lower risk of death compared to neutral women [ HR @number@ @number@ % CI ( @number@.74-0.97 ) ] .
Optimization and analysis of synergies are complementary approaches that focus on two aspects of multidigit coordination , sharing and covariation , respectively.
Optimization of flexibility , strength , endurance , and core control is critical.
Optimization of post-fracture treatment and care could reduce mortality of hip fracture in middle-aged and elderly individuals.
Optimization of sRAGE expression provides a basis for future large-scale production of this protein to meet medical needs.
Optimization of their management rests on collaboration between surgeons , anesthetists , and geriatrists.
Optimized marker panels are yet to be developed , and promising results require validation in large screening populations.
Optimizing nutrition in combination with exercise is considered an established , effective ergogenic practice for athletic performance.
Optimizing psychosocial and supportive care is critical , especially in the later stages of disease.
Optimizing the safety and efficacy of the therapy for clinical trials will require revisiting transplantation protocols.
Optimizing treatment for lumbar degenerative scoliosis is critical as surgical intervention , while potentially providing substantial clinical benefit also entails measurable risk and significant expense.
Optimum dose of TRF , morphological observation , activity of senescence-associated β-galactosidase ( SA-β-galactosidase ) , and cell proliferation were determined.
Options for treatment include behavioral therapies , medications , and surgical treatments such as chemodenervation.
OPTN had previously been involved in adult primary open angle glaucoma ( POAG ) .
Optometrists as front-line informers and educators of ocular health play a significant role in increasing public awareness of the risks of AMD.
Oracle inequalities of the regularized estimators are derived.
Oral administration of edible bird's nest extract ( EBNE ) improved bone strength and calcium concentration in the femur of ovariectomized rats.
Oral administration of PL extracts and its favorable safety profile could have significant implications in the prevention of skin cancer.
Oral administration of sunitinib significantly reduces vascular expression of these proteins.
Oral administration of T1-11 or JMF1907 significantly decreased protein level of ataxin-3-Q79HA in the pontine nuclei or cerebellum of SCA3 mouse.
Oral agents were aspirin in @number@ patients , ticlopidine in @number@ patients , clopidogrel in @number@ patients and warfarin in @number@ patients.
Oral agents were restarted after confirmation of hemostasis and no need for further invasive treatment.
Oral anticoagulation ( OAC ) is particularly challenging for these due to overlapping stroke and bleeding risk factor profiles.
Oral anticoagulation underuse is widespread as it is present within atrial fibrillation patients of all risk strata and in countries across all income levels.
Oral application of T1-11 or JMF1907 reversed mutant ataxin-3-Q79-induced cerebellar transcriptional repression in the SCA3 transgenic mouse.
Oral BPs are widely used for the prevention and treatment of osteoporosis and osteopenia.
Oral care protocols should avoid this iatrogenic practice , particularly when xerostomia alters the quality-of-life and worsens malnutrition.
Oral CE treatment had no effect on ER-β expression in postischemic microvessels of OVX and RS rats.
Oral conjugated equine estrogens ( CEE ) are the most used estrogen formulation for postmenopausal hormone therapy either alone or in combination with a progestin.
Oral contraceptive pill users and women living in Pakistan reported less impact on ADL , while married women report more impact of symptoms on ADL.
Oral examination was conducted by eight dentists trained in the World Health Organization ( WHO ) recommended examination procedure.
Oral gamma-hydroxybutyrate also counteracted phosphoramidon-induced brain neprilysin inhibition and Aβ accumulation.
Oral glucose tolerance test showed no disturbance of glucose metabolism.
Oral glucose tolerance tests showed decreased glucose reabsorption in the kidney of SAMP10 / TaSlc mice.
Oral glucose tolerance tests were performed in all participants at baseline and in @number@ individuals ( @percent@ ) after @number@ years of follow-up.
Oral health care practices are ever more frequently visited by frail elderly people.
Oral health is a contributory factor to general well-being and quality of life.
Oral health reflects overall well being for the elderly population.
Oral health research has yet to fully incorporate such dynamism in understanding the impact of oral disorders on the life of elders.
Oral health was assessed according to number of remaining teeth and presence or absence of regular dental care.
Orally administered medications may interact with various fruits , vegetables , herbal medicines , functional foods or dietary supplements.
Orally ingested 7KCh is readily metabolized by the liver and does not pose a toxicity threat.
Orally repeated administration of RJ preserved tear secretion , potentially through direct activation of the secretory function of the lacrimal glands.
Oral manifestation of senile purpura can also be induced by long periods of medication use leading to fragile areas of the mucosa.
Oral mucosa becomes thinner , smooth and looses stippling aspect with aging.
Oral squamous cell carcinoma was recently added in the case definitions for common HIV-related oral mucosa lesions.
Oral status and function were evaluated according to the number of remaining teeth , periodontal pocket depth , and maximal occlusal force.
Orange autofluorescence from lipofuscin in the lysosomes of the retinal pigment epithelium ( RPE ) is a hallmark of aging in the eye.
Orange pomace ( OP ) , a fiber-rich byproduct of juice production , has the potential for being formulated into a variety of food products.
Orbicularis oculi muscle activity was significantly greater in the older age group than in the younger age group for most actions.
Orbital and eyelid measurements were obtained for each patient , and adnexal photographs were taken.
Orbitomalar suspension addresses midfacial ptosis by restoring the natural function of the orbitomalar ligament and minimizes the development of postoperative lower eyelid malposition.
Orchestrating care is comprised of two subprocesses : building synergy and minimising strain.
Orchidectomy had also reduced the bone calcium level compared to normal control rats.
Ordered logistic regression analysis was conducted.
Ordered logits was estimated for self-rated health , and binary logits for functional limitation and healthcare utilization.
Ordered probit models are used to examine factors associated with self- and external assessments of health and discordant health ratings.
Ordinal logistic regression analyses were conducted and adjusted for demographic and cardiovascular risk factors.
Ordinal rank change was calculated to understand the clinical effect size of changes across the various domains after surgery.
Ordinal regression analysis was performed to determine independent correlates of increased FC.
Ordinal regression models showed that lower MBFV in the VA and BA is associated with shorter UPST.
Ordinary least-squares regression analyses examined the impact of change in coping on well-being.
Ordinary least squares regression models were estimated.
Ordinary least squares regressions were used to examine LTL in kilobase pairs in relation to racial discrimination and implicit racial bias.
Or , does early-life bilingual language experience change the brain ?
Or do they merely have difficulty deploying their theory of biology in the face of interference from the developmentally prior agency theory ?
Orexins have also been implicated in the regulation of glucose metabolism.
Orexins ( hypocretins ) initiate and maintain wakefulness , and loss of orexin-producing neurons causes narcolepsy.
Orexins play a role in many biological functions include sleep , feeding , and energy balance.
ORF1p and ORF2p demonstrate cis-preference for their encoding mRNA.
Organ and whole-body radiation exposures were calculated using OLINDA software.
Organ dose estimation is essential for pediatric and adult patient cancer risk assessment.
Organ dysfunction´s association with physical performance , and whether these associations are mediated by systemic inflammation , was also investigated.
Organelle genomes do not encode DNA repair enzymes and translocation of nuclear-encoded repair proteins from the cytosol seems to be a major control mechanism.
Organelles from AOBs of elderly donors were much fewer than those from young donors.
\ "Organically produced \ " appeared to not be that important compared with other criteria.
Organic anion-transporting polypeptide ( OATP ) 1B1 , OATP1B3 , and OATP2B1 transporters play an important role in hepatic drug disposition.
Organic colourants , ultraviolet ( UV ) light , cleansing solutions , dust and aging can adversely affect colour stability of silicone prostheses.
Organic peroxides and hydroperoxides are skin tumor promoters.
Organisational capacity , access to information and guidelines , and the inequality experienced by smaller organisations were key issues identified by participants.
Organismal aging and longevity are influenced by many complex interacting factors.
Organisms are repeatedly exposed to stressors that disrupt protein homeostasis ( proteostasis ) , resulting in protein misfolding and aggregation.
Organisms have developed common cellular signaling pathways and surveillance mechanisms to control the processing of aging against tumorigenesis.
Organisms have evolved to survive rigorous environments and are not prepared to thrive in a world of caloric excess and sedentary behavior.
Organisms have to cope with an unpredictable and dynamic environment.
Organisms rely on correctly folded proteins to carry out essential functions.
Organisms store energy from food and sunlight as an electrochemical gradient across the membranes of mitochondria , chloroplasts and bacteria.
Organizational activities were not significant when controlling for all covariates.
Organizational and activational hormone effects on the InM are discussed.
Organizational and individual factors influence the effectiveness of VR services.
Organizational and system support was perceived as wanting.
Organizational characteristics of importance include linking wages to DCW performance and providing an accessible training program.
Organizational variables were obtained from administrator surveys and publically reported data.
Organizations have better outcomes when workers are well trained , feel empowered , and are satisfied with their work.
Organizations need productive employees to survive.
Organizations worldwide are currently experiencing shifts in the age composition of their workforces.
Organophosphorus-induced delayed neuropathy ( OPIDN ) is a central and peripheral distal axonopathy characterized by ataxia and paralysis.
Organophosphorus pesticide poisoning causes tens of thousands of deaths each year across the world.
Organ size determination is one of the most intriguing unsolved mysteries in biology.
Organs that are very dependent on adult stem cells show increased susceptibility to aging , particularly organs that present a vascular stem cell niche.
Organ weight is one important indicator to discern normal from abnormal condition in forensic pathology as well as in clinical medicine.
Orgasmic disorder is frequently the downstream result of other sexual dysfunctions , particularly HSDD , or the result of a major psychosexual trauma.
Orienting responses are physiological and active behavioral reactions evoked by novel stimulus perception and are critical for survival.
Original articles , systematic reviews and meta-analyses , and relevant citations were screened.
Original functions associated with the melanopsin system include the photoentrainment of circadian sleep-wake cycles and the pupillary light reflex.
ORIGINALITY / VALUE : Personal viewpoint.
Originally identified using in vitro cellular models , this previously underestimated role of p53 has been confirmed in vivo in various genetically engineered mouse models.
Originally it was thought that ACh transferred retinal light information to the SCN.
Originally proposed as a salvage therapy for nonresponders to PDE5-Is , this approach has been inappropriately transformed into a combination therapy.
Original Schober's test ( OST ) and modified Schober's test ( MST ) are popularly conducted in daily rheumatology and orthopedics clinical practices.
Or , in a nutshell , geriatrics starts right in the middle of medical care.
Or is it ?
Ornithine transcarbamylase ( OTC ) deficiency is an X-linked disorder of the urea cycle.
OR @number@ @percent@ CI @date@ @number@ ) .
( OR @number@ @percent@ CI @number@ @number@ ; p = @number@ ) .
ORR and PFS were similar to the TH3RESA and EMILIA trials.
Or second , if autophagy is overactive , does inhibition of autophagy rescue cell , organ and organism demise.
ORs ( @percent@ CIs ) for the association between protein intake and weight loss were computed by using conditional logistic regression.
ORs were adjusted for age , race , and smoking status.
Orthodontic treatments increase the incidence of white spot lesions.
Orthogeriatric care is at present the best model of care to improve results in older patients after hip fracture.
Orthopaedic surgery is expensive and will be carefully scrutinized in the U.S. under health-care reform.
Orthopedic research into chronic discogenic back pain has commonly focused on aging- and degeneration-related changes in intervertebral disc structure , biomechanics , and biology.
Orthopedics complications are quite common : soft-tissue pathologies of the upper limbs , degenerative pathologies of the large joints or spinal cord , fall-related fractures.
Orthostatic BP changes were associated only with SBP-CV on home BP monitoring ( @number@ P = 0.002 ) .
Orthostatic hypotension ( OH ) is a common cardiovascular disorder , with or without signs of underlying neurodegenerative disease.
Orthostatic hypotension ( OH ) was the most commonly observed abnormality ( test positivity of @percent@ ) .
Orv.
Orv Hetil.
Orv Hetil.
Orv Hetil.
OSA affects the cerebral hemodynamics adversely.
OSA did not significantly influence vascular function in the skin microcirculation.
OSA promotes hippocampal atrophy , which is associated with memory impairment.
OSA-related cognitive deficits are highly prevalent and can affect various memory systems including overnight memory consolidation on a motor sequence task.
OSA risk was categorized as high or low based on responses to the Berlin Sleep Questionnaire.
OSAS is considered as an independent risk factor for hypertension , stroke and mortality.
OSAS subjects exhibited slightly prolonged central motor conductivity , whereas MEP amplitude was smaller in both patient groups.
OSCCs from smokers showed a lower prevalence of DNA aneuploidy compared to OSCCs from non-smokers.
Oscillations are not driven by upstream metabolic fluctuations , but rather by autonomous ionic mechanisms , the details of which are unclear.
Oscillations were closely coupled to exocytosis , indicated by coincident synaptopHluorin fluorescence enhancement.
Oscillometric measurement was performed twice on different days.
OSCP was further investigated and lysine @number@ is a nutrient-sensitive SIRT3-dependent deacetylation target.
Oseltamivir carboxylase activity was correlated with protein abundance in pediatric and adult liver microsomes.
OS has an intimate connection with ND , albeit low levels of ROS seem to protect the brain.
O sistema CoDe aumenta a probabilidade de classificar os óbitos com maior precisão em pessoas vivendo com HIV / Aids.
Osmotic fragility was assessed by lysis in hypotonic saline.
Osseointegration is a term that refers to the formation of a direct interface between an implant and bone without intervening soft tissue.
OSS is a skeletal biomarker that comprises osteoporotic and osteoarthritic changes observable on a hands X-ray.
OS survival in some elderly patients may be improved by more extensive therapy.
OSTA is a useful screening tool for OP in Han Chinese men over @number@ years.
Osteoarthritis Cartilage , @number@ 2039-47 ) .
Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most common diseases worldwide.
Osteoarthritis is a common cause of functional deterioration in older adults and is an immense burden on the aging population.
Osteoarthritis is an increasingly prevalent disorder with an incidence rate that rises sharply with age.
Osteoarthritis is a syndrome affecting a variety of patient profiles.
Osteoarthritis is characterized by progressive breakdown of articular cartilage.
Osteoarthritis is the most common disease of joints caused by degradation of articular cartilage and subchondral bone.
Osteoarthritis ( OA ) , also called degenerative joint disease , is the most frequently occurring chronic musculoskeletal disease , particularly affecting the aging population.
Osteoarthritis ( OA ) is a common and disabling disease.
Osteoarthritis ( OA ) is a common debilitating joint disorder , affecting large sections of the population with significant disability and impaired quality of life.
Osteoarthritis ( OA ) is a common form of degenerative joint disease.
Osteoarthritis ( OA ) is a common joint disorder with varying degrees of inflammation.
Osteoarthritis ( OA ) is a condition found worldwide , is strongly associated with aging and is the most common type of arthritis.
Osteoarthritis ( OA ) is a considerable health problem worldwide.
Osteoarthritis ( OA ) is a degenerative disease of the joints and is one of the leading causes of disability in adults.
Osteoarthritis ( OA ) is a disease of articular cartilage , with aging as the main risk factor.
Osteoarthritis ( OA ) is a highly prevalent human condition which is becoming an even greater health problem in an aging global population.
Osteoarthritis ( OA ) is a joint pathology characterized by progressive cartilage degradation.
Osteoarthritis ( OA ) is a leading cause of human suffering and disability for which disease-modifying treatments are lacking.
Osteoarthritis ( OA ) is a most commonly multifactorial degenerative joint disease along with the aging population , particularly in postmenopausal women.
Osteoarthritis ( OA ) is an aging-associated rheumatic disease characterized by articular cartilage degradation and elevated chondrocyte mortality.
Osteoarthritis ( OA ) is a whole joint disease , in which thinning and disappearance of cartilage is a critical determinant in OA progression.
Osteoarthritis ( OA ) is closely associated with aging , but its underlying mechanism is unclear.
Osteoarthritis ( OA ) is one of the most prevalent forms of joint disorder , associated with a tremendous socioeconomic burden worldwide.
Osteoarthritis ( OA ) is the most common chronic condition and principal cause of disability among older adults.
Osteoarthritis ( OA ) is the most common chronic joint disorder and its prevalence increases rapidly during midlife.
Osteoarthritis ( OA ) is the most frequent joint disorder and one of the leading cause of disability.
Osteoarthritis ( OA ) of the hand is highly prevalent in US senior citizens , developing in > 50% of individuals aged > 60 years.
Osteoarthritis ( OA ) of the hip joint is a common disorder , especially in aging peoples of Caucasian descent.
Osteoarthritis of the spine develops as a consequence of the natural aging process and is associated with significant morbidity and health care expenditures.
Osteoarthritis , osteoporosis , and sarcopenia , and especially their combination lead to hypomobility.
Osteoarticular infections ( OAI ) , which are often associated with bacteraemia , seem to be increasing.
Osteoblastic differentiation of vascular smooth muscle cells ( VSMCs ) is the most important cytopathologic foundation of arterial calcification.
Osteoblastic differentiation of vascular smooth muscle cells ( VSMCs ) plays an important cytopathologic role in arterial calcification.
Osteoblasts , the bone-forming cells of the remodeling unit , are essential for growth and maintenance of the skeleton.
Osteocalcin ( OC ) is a vitamin K-dependent protein synthesized during bone formation.
Osteocarcinoma cells treated with the hemagglutinin underwent obvious cell shrinkage , chromatin condensation , mitochondrial membrane depolarization , and apoptosis.
Osteoclastogenesis is associated with aging and various age-related inflammatory chronic diseases , including cancer.
Osteoclasts are cells derived from bone marrow macrophages and are important in regulating bone resorption during bone homeostasis.
Osteoclast-specific conditional HIF1α inactivation protects mice from estrogen deficiency-induced osteoclast activation and bone loss , as does systemic administration of a HIF1α inhibitor.
Osteoclasts were essentially absent from the bones of SHP-2-deficient mice , thus accounting for the osteopetrotic phenotype.
Osteolytic cancer in the bone leads to release of TGFβ from the bone via osteoclast-mediated bone destruction.
Osteonecrosis of the jaws ( ONJ ) is a known side effect of bisphosphonates and other anti-neoplastic drugs.
Osteons thus are strictly speaking not cylinders , as they tend to have elliptical cross-sections.
Osteopenia and osteoporosis are increasingly common in cancer patients , owing to the aging of the population and to new forms of cancer treatment.
Osteopenia is a condition in which bone mineral density is lower than normal , and it represents a sign of normal aging.
Osteopontin ( SPP1 , a secreted phosphoprotein @number@ ) is primarily involved in immune responses , tissue remodelling and biomineralization.
Osteoporosis and atherosclerosis seem to be epidemiologically correlated.
Osteoporosis and fragility fracture become common with advancing age in men.
Osteoporosis and its associated increased risk for fragility fracture is one of the most disabling consequences of aging in women.
Osteoporosis and obesity are important public health problems in an aging society.
Osteoporosis and overweight / obesity constitute major worldwide public health burdens.
Osteoporosis and sarcopenia are common in older age and associated with significant morbidity and mortality.
Osteoporosis and sarcopenia are the most frequent musculoskeletal disorders affecting older people.
Osteoporosis can significantly impact on the risk of developing a fracture.
Osteoporosis in elderly men is becoming an important health issue with the aging society.
Osteoporosis is a bone metabolic disease characterized by a compromised skeletal fragility , leading to an increased risk of developing spontaneous and traumatic fractures.
Osteoporosis is a chronic disease , carrying an elevated risk of fractures , morbidity , and death.
Osteoporosis is a common and debilitating bone disease that is characterised by low bone mineral density , typically assessed using dual-energy X-ray absorptiometry.
Osteoporosis is a common condition associated with aging but has been considered to primarily affect women because of the substantial effect of menopause on osteoporosis.
Osteoporosis is a common disorder in aging populations that imposes considerable health problems.
Osteoporosis is a complex multifactorial disorder of gradual bone loss and increased fracture risk.
Osteoporosis is a diffuse skeletal disease in which a decrease in bone strength leads to an increased risk of fractures.
Osteoporosis is a disease of aging , but it is apparently not recognised as such.
Osteoporosis is a major health problem in the aging population worldwide.
Osteoporosis is a major health problem in the elderly.
Osteoporosis is a major medical burden and its impact is expected to increase in our aging society.
Osteoporosis is a major public health issue in Japan , and key factors for its prevention are diet and exercise.
Osteoporosis is a major public health issue that is expected to rise as the global population ages.
Osteoporosis is a skeletal disease characterized by decreased bone mass and microarchitectural changes in bone tissue that increase the susceptibility to fracture.
Osteoporosis is a skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture.
Osteoporosis is a skeleton disease characterized by low bone mineral density and deterioration of bone tissue , resulting in an increased risk of fragility fracture.
Osteoporosis is a widespread disorder affecting millions of individuals of all ethnic backgrounds worldwide , particularly among older women.
Osteoporosis is , because of its high prevalence and morbidity , a major health problem in our aging population.
Osteoporosis is increasingly recognised as a health threat in the ageing male.
Osteoporosis is one of the most common skeletal disease featured by osteopenia and adipose accumulation in bone tissue.
Osteoporosis is predominantly a condition of the elderly with a consequent increase in bone fragility and susceptibility to fracture.
Osteoporosis is still a serious issue in healthcare , and will continue to increase due to the aging and growth of the population.
Osteoporosis is the most common cause of bone fragility , especially in post-menopausal women.
Osteoporosis leads to hip fractures in aging populations and is diagnosed by modern medical imaging techniques such as quantitative computed tomography ( QCT ) .
Osteoporosis leads to @number@ million fractures and @number@ hospitalizations annually.
Osteoporosis may be involved in the onset of OA in elderly patients.
Osteoporosis-related fractures constitute a major health concern not only in women but also in men.
Osteoporosis-related fractures increase mortality and reduce quality of life.
Osteoporosis represents a major public health problem through its association with fragility fractures , primarily of the hip , spine and distal forearm.
Osteoporosis represents a serious health problem worldwide and is associated with an increased risk for fractures and mortality.
Osteoporosis treatment requires managing fall risk.
Osteoporotic fractures are a public health problem and their incidence and subsequent economic and social costs are expected to rise in the next future.
Osteoporotic ( OP ) fracture data were collected and verified by specialists during @number@.8years.
Osteoporotic vertebral body fractures are an increasing clinical problem among the aging population.
Osteoprotegerin ( OPG ) , transforming growth factor-β1 ( TGF-β1 ) and TGF-β2 are cytokines closely associated with bone metabolism.
Osthole and 7-hydroxycoumarin slightly , but significantly , enhanced transepidermal water loss after a consecutive 5-day administration.
Osthole with the most lipophilic characteristic demonstrated the greatest skin accumulation , followed by coumarin and 7-hydroxycoumarin.
OS was shorter in the frail versus non-frail ( median @number@ vs @number@.9m , p < 0.001 ) .
OT and AVP assays tolerated @number@ freeze-thaw cycles , making this protocol useful in a variety of field conditions.
OTA-producing fungi belonged to different Penicillium species including P. chrysogenum , P. commune , P. polonicum and P. verrucosum.
OTC supplementation eliminated the aging-associated differences in hepatic GSH and GSH / GSSG ratio.
Other adverse events included increases in the pigmentation of the iris , perorbital areas and eyelashes.
Other articles were searched on Scopus and Web of Knowledge.
Other Asian countries face similar problems , with South Korea having the fastest aging population worldwide , followed by China and Thailand.
Other aspects look into the mechanisms to coordinate research within a European context.
Other aspects of LS did not predict death after accounting for functional status and multimorbidity.
Other aspects of palliative care may benefit from further instrument development research.
Other associated side effects are the presence of undesired activities in blood products , which can produce thrombotic events or adverse reactions.
Other authors ( n = @number@ ) confirmed the themes by reviewing a subset of transcripts and the draft themes.
Other baseline characteristics including health and functional performance were also evaluated.
Other biomechanical factors may also define profiles , such as joint malalignment , loss of meniscal function , and ligament injury.
Other body regions may also be involved ( especially the head ) .
Other cancer-related areas may represent more universal degree of impact.
Other caregivers disavow its current relevance.
Other causes of anemia whose prevalence is not well established include myelodysplasia , copper deficiency , hypothyroidism , and sarcopenia.
Other CD4 effector responses and memory generation are also impaired.
Other challenges of the decision-making process are manageable.
Other characteristics were age , sex , marital status , education level , self-rated health , and chronic diseases.
Other cohorts with similar data included the Cardiovascular Health Study , the Framingham Heart Study , and the New England Centenarian Study.
Other common obstacles within LTC homes include accommodating personal preferences , cultural preferences , and therapeutic diets.
Other common undesirable effects such as sedation , constipation ( which can be fatal ) , urinary incontinence and hypersalivation further limit its use.
Other comorbidities are reviewed.
Other complications included mild respiratory insufficiency , delirium , bleeding , etc.
Other contributory factors are poor diet and some medications , such as aspirin.
Other control variables were added to the model.
Other coordinately expressed modules were enriched for lymphoid and / or myeloid signature transcripts and genes induced by IL-17 in keratinocytes.
Other correlations , e.g. between high consumption of antioxidants , were not demonstrated here , but cannot be excluded.
Other dietary variables , smoking , alcohol intake , D-dimer , interleukin @number@ and homocysteine showed no important associations with MAMC and FFMI.
Other differences were observed for skin hydration , as well as skin laxity , which tended towards significance.
Other distinct adipose tissue macrophage subtypes have been identified by surface marker expression and their functions characterized.
Other domains of cognitive function were not associated with eGFR.
Other domains were improved by both interventions , but no typical pattern could be identified.
Other drinking patterns were not associated with lower odds of incident functional limitation.
Other drugs have unpredictable effects : the mechanism is not always known but sometimes appears to involve changes in the hydration of various ocular structures.
Other effective fall prevention strategies include maximizing vision through cataract surgery and occupational therapy interventions in visually impaired older people.
Other evidence from regression analyses suggests either no significant associations between time post stroke or age or mixed results.
Other evidence has suggested that tau and amyloid pathology may arise independently.
Other examined risk factors may influence progression risk , but evidence for or against this was weak due to wide confidence intervals.
Other factors also influence the hippocampal volume , but their interactive effect has not been investigated before in cognitively healthy individuals.
Other factors could increase or decrease demand , as discussed in the article.
Other factors include basal metabolic rate , increased protein dietary requirements , and chronic inflammation secondary to age-related changes in cytokines and oxidative stress.
Other factors , including age , previous diabetes drugs and duration of treatment added low predictive power ( < 1% ) .
Other factors including age , race , income , health behaviors , and cardiovascular risk factors only partially explain the relationship.
Other factors require further discussion.
Other factors such as age , sex , comorbidity , physical function , cognitive function , and oral intake level were also assessed.
Other factors , such as angiopoietins , cross talk with VEGF , modulating its effects.
Other fatty acid biomarkers and estimated dietary SFAs or MUFAs were not significantly associated with incident diabetes.
Other findings did not appear to be predictive.
Other foods with significant AGEs included fish , cheese , vegetables , and vegetable oil.
Other forms included financial exploitation , physical mistreatment , and abandonment.
Other functions concern metabolism , cell cycle arrest , apoptosis , destruction of potentially damaging reactive oxygen species and proteostasis.
Other functions such as identity are used less often by people with psychological distress.
Other genes important for the CD4 ( + ) cell function may share that sequence and may be similarly regulated and affected.
Other genetic and environmental factors may also play a role.
Other GI physiology also varies with age potentially having an impact on drug absorption.
Other glutamatergic excitatory signals are transmitted to Purkinje cells via parallel fibers of cerebellar granule neurons.
Other groups showed no impact of pre-treatment.
Other heavy metals were not measured.
Other Hispanics ( Hispanics excluding Mexican Americans ) had higher Odds of sugar-containing food consumption compared to non-Hispanic Whites ( adjusted model ) .
Other hormones were not associated with fat measures.
Other HRV parameters were similar.
Other important meat quality criteria were : general appearance , overall health , price , nutritional value , and containing no medical residues.
Other important outcome parameters ( embryo quality , pregnancy rates ) were not correlated to spindle nor zona inner layer analysis.
Other important treatment options include pulmonary rehabilitation , oxygen therapy , noninvasive positive airway pressure , and depression and osteopenia screening.
Other independent variables were measured.
Other indicators of material hardship , such as having a major financial difficulty , unmet health need , and inadequate housing , were not significant.
Other indicators of socioeconomic status ( e.g. , education , income ) did not interact with the APOE epsilon4 allele in predicting CD.
Other inflammatory markers showed no statistically significant associations with the outcome.
Other issues included difficulties with positioning and handling patients ' uncontrollable movements.
Other large trials involve topical clonidine and further ketamine combinations.
Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males.
Other magnetic resonance imaging lesions that were graded included presence of lacunes , white matter lesion , and total brain volumes.
Other measured factors included age , education , living arrangements , smoking and alcohol history , and physical activity.
Other measured parameters did not differ between groups.
Other measures included self-management ability ( assessed with the SMAS30 ) and cognitive skills ( assessed with the clock drawing test ) .
Other measures of cardiovascular , thermoregulatory , and perceptual responses were unaffected by fan use in both groups.
Other measures of inductive reasoning , such as Raven's Advanced Progressive Matrices , also showed similar age group mean differences across settings.
Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease.
Other mechanisms such as the compromised inhibitory regulation in the auditory system and the aging effect in CI users might also play a role.
Other mechanisms were also identified that likely contribute to α-synuclein modifications.
Other mechanistic pathways entail cell signaling , apoptosis and gene expression.
Other medical conditions increase with age , and these and their treatments will impact on sexuality and the way it can be expressed.
Other medications and treatments are more appropriate and efficacious for depression , anxiety , and insomnia in this population.
Other medications assessed , including antihypertensives , diuretics and antipsychotics , were not associated with outcomes.
Other metabolites , such as triterpenoids , can also be released.
Other modalities include use of retinoids which regulate gene transcription with subsequent cellular differentiation and proliferation.
Other mutations and VUS were observed in @number@ patient each.
Other mutations ( TERC , surfactant proteins genes ) are only rarely evidenced in adults.
Other neurologists , such as John Hughlings Jackson , discussed a dissociation between music as an emotional system and language as an intellectual system.
Other noninvasive or minimally invasive treatment modalities can be considered to combine with MFU-V for the optimal treatment response.
Other ( nonpermanent ) fillers were also used without incident.
Other nutrition-related factors associated with prolonged LOS were lower HGS at admission , receiving nutrition support , and food intake < @percent@.
Other objectives of the study were to evaluate micronutrient adequacy of each pattern and to determine the association of diet with sarcopenia.
Other outcomes including hospitalization and readmission rates , hospital length of stay , and cost of care are similarly associated with increasing age.
Other parameters did not show a significant relation to dentition.
Other parameters than sleep and memory measurements could play an important role on the association.
Other parameters were also found to influence BMD , and once these were included in multivariate analysis , age was no longer associated with BMD.
Other patients at risk undergo serum galactomannan testing three times weekly.
Other plausible mechanisms underlying the relationship between diet and cognitive decline , such as inflammation and oxidative stress , have been established.
Other potential mechanisms that may underlie RAS blockade's mitochondrial benefits are TGF-β down-regulation and up-regulation of Klotho and sirtuins.
Other potential mediators of this pro-inflammatory endothelial phenotype are increases in immune or senescent cells in the vasculature.
Other preferences included \ "not moving \ " and \ "returning to India. \ "
Other progeria syndromes were considered unlikely because premature greying , hypogonadism , and scleroderma-like skin disease were not present.
Other proteins ( including P-tau and apolipoprotein D ) had effects even after adjusting for CSF Aβ42.
Other proteins such as brain-associated signal protein @number@ and paralemmin @number@ became less tightly bound in the older regions of the lens.
Other rare non-synonymous germline mutations were also detected in DICER and ELAC2.
Other regarding were age , sex , occupation and predisposing factors.
Other regimens are indicated if methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa is a concern.
Other regional pathology scores for plaques , NFTs , and LBs were similar between groups.
Other regions , including cortical and subcortical structures , have also been implicated in this syndrome.
Other relevant genes include those encoding for the neuroendocrine stress axis , growth factors , and other monoaminergic systems.
Other relevant outcomes were the levels of BDNF , IGF-1 , Apo e4 carrier state , and self-ratings.
Other research and development strategies are needed , especially for the treatment of AD.
Other risk factors for admission to hospital were examined using the Mann-Whitney test pre-and post-CVW admission , including falls , living alone , and cognition.
Other risk factors include advancing age , female gender , visual impairments , cognitive decline especially attention and executive dysfunction , and environmental factors.
Other risk factors such as its co-morbidities with chronic viral hepatitis in the presence or absence of human deficiency virus were discussed.
Other safety outcomes of TIMI minor / minimal bleeding and thrombocytopenia were not different between the two groups.
Others are explained by aging , anatomic variants , physiological phenomenon or tobacco use.
Others are tempted to promote a fantasy old age , and even rediscover , through scientific discoveries , the myth of eternal youth.
Others can be expected to follow.
Other shared features include low glycemic load , less inflammation and oxidative stress , and potential modulation of aging-related biological pathways.
Others have found no effect of fortification on liking.
Others have proposed that these peculiar DDR foci might not be sites of damaged DNA per se but instead stable chromatin modifications , termed DNA-SCARS.
Others , however , are not so fortunate.
Other significant contributors included larger social networks and higher levels of acculturation.
Other significant factors include cerebral amyloid angiopathy ( @percent@ ) and Lewy bodies ( @percent@ ) .
Other similarities were also observed with stroke and screening positive for cognitive decline in men , and number of diseases and gait speed in women.
Others ( mostly men ) , on the contrary , relied on their children to do the sorting out after they had died.
Others not belonging to these two conditions were classified into orthostatic normotension.
Other SNPs revealed genotype-specific mean survival advantages ranging from @number@ to @number@ years.
Other socio-relational variables , specifically generalized trust and trust in neighbours were associated with depression in women but did not act as mediating variables.
Others recognise the benefits of physical activity , but report a range of barriers to physical activity participation.
Others , such as green tea , provide photoprotection against ultraviolet-induced DNA damage.
Others , such as serum hepcidin , hold considerable promise , although they are not yet widely used.
Others , such as vitamins are frequently utilized.
Others suggest a decline of driving ability in the process of normal aging and an increasing involvement of older drivers in car crashes.
Others suggest that auxiliaries can be learned without Universal Grammar , citing evidence of piecemeal learning in their support.
Others terminated GACA projects ( @percent@ ) or abandoned academic medicine altogether.
Other steroids were determined using stable deuterated internal standards.
Other stress situations showed modest associations in the middle-aged and young-olds.
Other structural markers of neurodegeneration typically affected in prodromal AD but seeming largely unimpaired in preclinical AD were also examined.
Other studied dopaminergic polymorphisms did not show an association with reaction time.
Other studies are necessary in order to confirm these results.
Other studies demonstrate the appropriateness of CaHA filler for volume restoration to areas including the mid face , lower face and hands.
Other studies have identified risk factors as well as protective factors that can serve as target points for the development of effective interventions.
Other studies have reported optimal testosterone levels for better global cognitive function and a reduced risk of cognitive decline.
Other studies investigated putative underlying mechanisms like free iron , inflammation , cytokines , and so on.
Other studies should be conducted to further explore FP role in cancer supportive care.
Other studies suggest that epigenomic plasticity and aging-associated changes in DNA methylation also contribute extensively to aberrant DNA methylation in cancer.
Others were alive and there was no tumor recurrence or metastasis.
Other techniques and modifications with evidence of reduced failure risk are bicortical screws , hydroxyapatite coatings , double screws , and expandable screws.
Other techniques and technologies will need to pass the test of time to be able to conquer their space in this growing market.
Other than antipsychotic medications , off-label medications , and restraint , few treatment options are available.
Other than autologous fat and certain preformed implants , the collagen family products were the only Food and Drug Administration approved soft tissue fillers.
Other than female gender , residing in urban / semi urban areas and being overweight or obesity were associated with the occurrence of hypertension.
Other than the conventional period life expectancy , cohort life expectancy measures the lifetime of real individuals from the population under consideration.
Other therapeutic options , such as radiation or systemic therapies , should only be considered when excision is impossible.
Other tools may be used soon after more studies are performed , particularly trabecular bone score , quantitative ultrasound , bone turnover markers.
Other treatments in development target oxidative stress , the failure to resolve inflammation , aberrant repair mechanisms , and accelerated lung aging.
Other trials consider that dose-adjustment to renal function is need in elderly patients , but these trials are very few.
Other trials may include several biases such as accrual of \ "only fit \ " elderly patients.
Other tympanometric measures also were taken and analyzed.
Other tympanometric measures demonstrated little change after @number@ years.
Other types of renal disease frequently encountered during the late period include renal AA-amyloidosis and tenofovir-related kidney disease.
Other underlying factors can be the presence of multiple diagnoses and the use of polypharmacy.
Other useful means of conversation include division of speech , emphasized gestures and , in the case of inhibited spoken communication , writing.
Other variables such as time to surgery , delirium , and functional status were measured infrequently.
Other vector control strategies which do not rely on the vector entering houses are needed if elimination or intensified control is to be achieved.
Otherwise , IR-induced non- / multi-targeted effects are also evident.
Otherwise , Nef- but not Tat-treated cells displayed early inhibition of autophagy.
Otherwise , one may encounter significant delays arriving at the destination.
Otherwise , remote-communication could lead to reduced face-to-face communication and social exclusion.
Otherwise , two studies have shown healing acceleration of bone fractures with teriparatide.
Otic capsule bone demineralization occurs late in the disease process.
OT or VATS lobectomy was performed in patients who met enter criteria and clinical data was collected.
Ototoxicity is a major cause of the loss of hearing and balance in humans.
OTU cluster analysis and Venn diagram showed that the intestinal microbial community of Gaotian villagers is different from that of control group.
OTUD3 interacts with , de-polyubiquitylates and stabilizes PTEN.
OTUD3 transgenic mice exhibit higher levels of the PTEN protein and are less prone to tumorigenesis.
Our ability to make assumptions about the relatedness of multisensory stimuli is partly based on their temporal and spatial relationships.
Our aging population is rapidly growing and accounts for @percent@ of critical care patients and @percent@ of medical-surgical patients in the hospital.
Our aim in this project is to understand how age-related changes to neural structure and function interact to support cognitive abilities across the lifespan.
Our aim in this qualitative descriptive study was to identify and explore these features in the context of LTCs.
Our aim in this study is to determine whether SUA is associated with cardiac hypertrophy in CKD patients , focusing on any sex differences.
Our aim in this study was to elucidate the ratio of wild-type transthyretin in amyloid deposits in familial amyloid polyneuropathy patients.
Our aim in this study was to evaluate hyoid bone movement trajectories and the age-related changes during swallowing in healthy subjects by ultrasonography.
Our aim in this study was to examine the association between breastfeeding duration and cardiorespiratory fitness , isometric strength , and explosive strength during adolescence.
Our aim in this study was to investigate how lymphocyte subgroups in peripheral blood are affected by aging among males and females.
Our aim is to compare diagnostic process and management of AD in PC and specialist care ( SC ) .
Our aim is to describe and compare the use of PHC between elderly immigrants and Norwegians.
Our aim is to illustrate the different formulas available and their respective advantages and disadvantages.
Our aim is to show computationally how these coupled effects can impact evolving aortic geometry and mechanical behavior.
Our aims were to analyze and compare the SST expression during normal aging and colorectal carcinogenesis at mRNA and protein levels.
Our aims were to assess whether there was an association between low albumin levels and mortality and whether the severity adversely affects outcomes.
Our aims were to describe the patient population referred for ART calls , reasons for and interventions during ART calls , and complications following them.
Our aim was to analyze the status of end-stage renal disease ( ESRD ) management in the Portuguese-speaking and Spanish-speaking countries of South America.
Our aim was to ascertain the incidence and risk factors associated with MACEs in Chinese patients.
Our aim was to assess both their relation with RRD features and their influence on the posttreatment outcome.
Our aim was to assess nutritional status among geriatric trauma patients.
Our aim was to assess the relationship between SUA and measures of EF in a cohort of elderly community-dwellers.
Our aim was to assess whether age-related increase in adiponectin is associated with a decrease in renal function.
Our aim was to assess whether effects of the SMW intervention were comparable with the original randomized controlled trial ( RCT ) .
Our aim was to assess whether risk of stroke in mid life is associated with cognitive decline over @number@ years of follow-up.
Our aim was to compare patients who differ in age-of-onset , while controlling for illness duration , and number of depressive episodes.
Our aim was to correlate proliferative and apoptotic activities in aging human colonic epithelium and colorectal cancer.
Our aim was to create a bdelloid rotifer model to use in high-throughput viability and non-invasive assays.
Our aim was to define the most toxic wavelengths in the blue-green range on an in vitro model of the disease.
Our aim was to derive an equation for estimating LBM in children.
Our aim was to describe the apolipoprotein profile with respect to cardiovascular risk in a Canadian First Nation community.
Our aim was to describe the cognitive profile associated with prior TBI exposure among community-dwelling older adults without dementia-an understudied but potentially vulnerable population.
Our aim was to determine if ECG-derived QRS duration is associated with UCP2 DD genotype in a cross-sectional Australian aging rural population.
Our aim was to determine the biological age of ischemic stroke patients and compare their aging with controls of the same chronological age.
Our aim was to determine the degree to which genetic and environmental variation in subcortical MD is distinct from variation in subcortical volume.
Our aim was to determine the prevalence , risk factors , and time course of sensory extinction in the acute stroke setting.
Our aim was to determine whether sleep in the second year of life is associated with the development of body composition throughout childhood.
Our aim was to determine whether such a relationship exists in stroke.
Our aim was to discover plasma proteins associated with brain amyloid-β ( Aβ ) burden in non-demented older individuals.
Our aim was to establish a framework of research priorities in HIV , disability and rehabilitation.
Our aim was to establish a French version of the MCQ and to evaluate its psychometric properties in a lifespan perspective.
Our aim was to estimate the global and regional burden of IHD in @number@ and @number@
Our aim was to estimate the predictive value of four novel cardiovascular risk markers for the U.S. general population.
Our aim was to evaluate the association between slow gait speed and rapid cognitive decline among oldest-old men in Taiwan.
Our aim was to examine the clinical relevance of white matter hyperintensities ( WMH ) in HIV.
Our aim was to examine whether adversity in childhood is associated with shortening of telomere length.
Our aim was to explore the association between objectively measured PA and physical performance in old age.
Our aim was to explore the social and economic effects of caring for an older dependent person , including insight into pathways to economic vulnerability.
Our aim was to identify a rat Acsl isoenzyme that could be inhibited by VPA in vitro.
Our aim was to identify loci showing differential DNA methylation related to serum lipid levels.
Our aim was to identify molecular biomarkers that could be helpful for the diagnosis and treatment of pRCC.
Our aim was to identify novel genes associated with hand OA and examine the underlying mechanism.
Our aim was to identify sociodemographic characteristics , technology use , and sleep patterns among college students and their independent relationship to recommended PA.
Our aim was to investigate associations of BC measures with different levels of cognitive function in late-life.
Our aim was to investigate how HF affects the functional properties of BM-MMSC.
Our aim was to investigate the association between self-reported psychological distress and risk of dementia-related mortality.
Our aim was to investigate the association between vitamin D status and the future risk of MCI and dementia in older adults.
Our aim was to investigate the associations of gait and gait variability measures with incident falls risk.
Our aim was to investigate whether testosterone levels are associated with serum vitamin D levels and whether seasonal variation exists.
Our aim was to measure CB1 levels in brains of PD patients in vivo and to investigate the relation between CB1 availability and LID.
Our aim was to provide structural and phenotypic evidence of lymphatic-like structures in the human choroid , including details of its development.
Our aim was to review and discuss the main causes of pain in patients with osteoporosis and suggest possible strategies for its management and prevention.
Our aim was to study how moving through greater life-space areas is associated with greater physical activity of community-dwelling older people.
Our aim was to study the feasibility of QCT / X-FEM analysis to predict fracture properties of vertebral bodies.
Our aim was to systematically review this association.
Our aim was to test whether this regional cortical maturation is reflected in regional changes of sleep SWA.
Our algorithm , CLuster-based Adaptive Sleep Staging ( CLASS ) , detects QS if it remains relatively more discontinuous than non-QS over PMA.
Our algorithm defines consecutive genomic regions based on the physical positions of the variants , assuming an inhomogeneous Poisson process and groups together nearby variants.
Our algorithm speeds up the quantification task while improving reproducibility.
Our analyses also identified @number@ differentially expressed genes that responded to stroke in an age-independent manner.
Our analyses broadly support the generalisability , repeatability , construct validity , and responsiveness of this new interval-level score.
Our analyses further showed that the two networks tend to merge with increasing age.
Our analyses indicate a promising target region for interventions aimed to reduce risks of many major human diseases and mortality.
Our analyses revealed significantly larger gray matter volumes in females compared with males for BA @number@ and BA @number@ bilaterally.
Our analyses revealed significant relationships between most RAVLT indices and age and education.
Our analyses revealed that at advance ages , GC-poor genes appear to be induced while GC-rich genes are repressed.
Our analyses suggest that participation in the newly-opened community salon was associated with a significant improvement in self-rated health over time.
Our analyses were complemented by investigating the heterogeneity that was implied by the differences in genetic variance components in the four subscales of the PAI-BOR.
Our analyses were conducted on data for @number@ countries between @number@ and @number@ a total of @number@ data points.
Our analysis also indicates that there is no a relationship between the degree of physical activity and Q10 levels when the general population is studied.
Our analysis confirms consensus GR target genes and predicts potential drug mimickers.
Our analysis does not reject steepening , with the exception of the 0-year-olds.
Our analysis echoes recent reviews suggesting patient selection and monitoring when anti-resorptive treatment is discontinued.
Our analysis highlighted two features which might have played an important role in the longevity observed in Okinawa.
Our analysis identifies a region in the ITGB3 gene that potentially harbors disease susceptibility loci for Alzheimer's disease.
Our analysis identifies focal deficits in the SAL network that may be mitigated with suppression of plasma virus.
Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging.
Our analysis indicates that inherited mitochondrial DNA variation does not have a major role in the risk of developing the disorder.
Our analysis is based on data for @number@ developed countries from the Human Mortality Database for the period @number@ to @number@
Our analysis is based on fixed effects estimates.
Our analysis is focused on writers and musicians from the 17th through the 21st centuries.
Our analysis offers lessons to other states shifting to MMLTC.
Our analysis of the largest pediatric case series reported to date adds pediatric-specific experience to the management of this opportunistic infection in children.
Our analysis results on discriminatory abilities provided evidence that KDCI is superior to other comorbidity indices on incident dementia in terms of comorbidity adjustment.
Our analysis revealed a substantial increase of neuromuscular response delays and a decrease of the command amplitudes with age.
Our analysis revealed that alexithymia , anxiety , and depression in FM patients showed increased levels compared to healthy controls.
Our analysis reveals that targeting microglia may hold potential promise in the prevention and treatment of AD.
Our analysis suggests it may not be reliable with this population , even with minor modifications that were made.
Our analysis suggests that age differences in interference control have multiple sources , but also offer multiple opportunities for compensation and intervention.
Our analysis suggests that based on expected changes in the population age structure by then , the annual number of hospitalizations will increase by @percent@.
Our analysis therefore suggests that the said association is not largely due to the confounding effects of lung cancer.
Our analytic sample comprises @number@ Chinese respondents and @number@ Korean respondents aged 45-79.
Our AoA ratings are available for research or other purposes.
Our APOE-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region.
Our approach also yielded the finding that senescent cells in tissues of aged mice are larger than nonsenescent cells.
Our approach highlights a powerful experimental strategy with broad applicability for future studies of disorders with complex genetic etiologies.
Our approach highlights the power of data exchange and the importance of an interrelationship between clinical and research efforts for disease gene discovery.
Our approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.
Our approach included direct observation , literature review , meeting discussions , and data compilation.
Our approach involves expression of progerin , a truncated form of lamin A associated with premature aging.
Our approach is described.
Our approach is tested on a large , gender-balanced database with @number@ subjects , with an age range between @number@ and @number@
Our approach is to monitor gait for early warning signs of morbidity.
Our approach results in a relatively \ "error-free \ " continuous variable that can serve as a dementia-specific phenotype.
Our approach was applied to two distinct chronic patient management programs.
Our article discusses the current understanding of cellular senescence , its interplay with miRNAs regulation , and how they both contribute to disease processes.
Our assay consists of three simple steps : enrichment , Matrigel invasion assay , and immunostaining.
Our assay's improved sensitivity allowed us to detect mutations with variant allele frequencies as low as @number@
Our body cells exhibit wide variation in sensitivity to iron toxicity.
Our body habitat-associated microbial communities are of intense research interest because of their influence on human health.
Our brain operates by the way of interconnected networks.
Our case highlights patient selection and procedure for this new modality of coronary artery disease treatment.
Our case provides anecdotal evidence , supported by other studies , to justify future , larger studies on chronic pain using this therapy.
Our case report illustrates the relationship between psychosis and Sheehan's syndrome.
Our case showed clearly marginated whitish papules.
Our coated microchannel networks also displayed a significant reduction in the coagulation response under whole blood flow.
Our colleagues have reported previously that human pancreatic progenitor cells can readily differentiate into insulin-containing cells.
Our community-academic partnership developed a program to increase and assess fall risk screenings by community providers.
Our comprehensive analysis revealed that many of the plants growing in the Judea region may hold a geroprotective potential.
Our comprehensive list of words and topics is available on our web site for deeper exploration by the research community.
Our computational model of the IVD illustrates its ability to simulate the evolving chemical and mechanical environments occurring during the early ageing process.
Our concept is midfacial volume restoration in first place.
Our conceptual discussion is based on insights gained from a 3-year project on older homelessness in Montreal , Canada.
Our constructed 4D infant cortical surface atlases with developmental trajectories based parcellation will greatly facilitate the surface-based analysis of dynamic brain development in infants.
Our controls consisted of patients younger than age @number@ years on anti-TNF treatment and patients > 60 years on treatment with immunomodulators.
Our cross-sectional analysis suggests that age-related site-specific muscle loss could assess the decrease in absolute muscular strength , but not the ratio of muscle strength.
Our cross-sectional autopsy findings indicate that the fornix is involved by p-MAPT neuropathology secondary to hippocampal involvement by AD neuropathology.
Our current approach and techniques for upper eyelid blepharoplasty and brow lifting are described.
Our current data showed that Klotho gene rs571118 SNP was associated with chronological aging , but not biological aging , in a Han Chinese population.
Our current knowledge on the autophagic pathways and molecular mechanisms and regulation of autophagy will be summarized in this review.
Our current knowledge on the causes of sarcopenia is still fragmentary.
Our current state of knowledge is based predominantly on studies conducted among middle-aged adults or young elderly people.
Our current understanding of tauopathies has yielded promising therapeutic interventions but have all failed in clinical trials.
Our cytokine data concur with national differences in the prevalence of age-related illnesses linked to inflammatory physiology , including cardiovascular disease.
Our data also indicate a different rate of senescence of different performance traits associated with scoring over a male's lifetime.
Our data also points to potential pathways that could be targeted to develop drugs and drug combinations for both HGPS and normal aging.
Our data also provide a molecular explanation on how SPRTN deficiency causes the premature aging and cancer predisposition disorder Ruijs-Aalfs syndrome.
Our data also suggest that HHT patients to a lesser degree than the background population are affected by cancer.
Our data also suggest that the role of Wt1 in regulating fertility is conserved in mammals.
Our data also suggest that with normal aging , endogenous acyl-ghrelin levels are less tightly linked to GH regulation.
Our data are consistent with another study that found systemic inflammation in general , and CCL11 protein specifically , suppresses hippocampal neurogenesis.
Our data are consistent with these statements and suggest that the likelihood of similar processes occurring in normal individuals increases with age.
Our data are consistent with this intensified signal's potential contribution to the extent of initial myocardial injury , but conversely to accelerated recovery.
Our data are made available online ( @url@ to facilitate research in this long-lived species.
Our database consisted of prevalence estimates in @number@ age groups taken from @number@ studies.
Our data compare favorably to other studies where ease of laryngeal mask airway placement was reported.
Our data confirm a marked motion-processing deficit specific to some AD patients , and greater than any form-processing deficit for this group.
Our data confirm that diabetes worsens the LJM in the elderly , increasing the cross-linking of collagen by the non-enzymatic advanced glycation end products formation.
Our data confirm the global trend of stabilizing prevalence rates of childhood obesity at a high level and add important information for individual age groups.
Our data could furthermore provide a better understanding of the pathophysiology of cognitive and motor disturbances in elderly with SVD.
Our data define a molecular switch whereby redox-mediated posttranslational modification controls both neurogenesis and neurodegeneration via a single transcriptional signaling cascade.
Our data demonstrate a causal role of the hyperactive S6K1 in eNOS uncoupling leading to endothelial dysfunction and vascular aging.
Our data demonstrate critical roles of Dmp1 in preventing mammary tumorigenesis and raise the possibility of treating breast cancer by restoring Dmp1α expression.
Our data demonstrated that complement might be pivotal in the down-regulation of Klotho in IRI leading to a permanent deficiency after years from transplantation.
Our data demonstrates that a cyclic AMP analog , 8-Br-cAMP , enhances the efficiency of cellular reprogramming.
Our data demonstrate that adiposity is a critical factor in the age-associated pathological responses to systemic anti-cancer IT.
Our data demonstrate that beneficial endurance training effects are not linked to the upregulation of the examined neurotrophins.
Our data demonstrate that sAβPPα regulates RACK-1 gene expression through PI3K / Akt-dependent pathway , inducing c-Rel nuclear translocation and NF-κB activation.
Our data demonstrate that the HUGE formula is more reliable than MDRD and CKD-EPI , particularly in persons aged over @number@
Our data demonstrate that the typical shift in striatal activation from reward receipt to reward anticipation in young adults disappears with healthy aging.
Our data demonstrate that TTR proteolytic activity is required for the neuroprotective effect of the protein constituting a putative novel therapeutic target for AD.
Our data do not preclude a role of inflammatory mechanisms in adipose or other tissues which may not be reflected by immune mediators in plasma.
Our data do not support the notion that vascular pathogenesis might underlie executive dysfunction.
Our data emphasize the aspect of risk factor control , suggesting that dedicated medical care might prevent cognitive decline in CKD patients.
Our data further emphasizes the pivotal role played by Wnt / β-catenin signaling in bone mass regulation.
Our data furthermore suggest that neuronal hyperactivity may be the mechanism by which this regulation occurs.
Our data highlight a mechanism by which an enzyme involved in vitamin A metabolism can improve B cell resistance to oncogenesis.
Our data highlight the potential importance of considering motivational states such as flow in understanding cognitive optimization in adulthood.
Our data high-light the technical difficulty of producing species-specific antibodies for both western blotting and immunohistochemistry.
Our data identified melatonin as a novel inhibitor of Sirt1 and suggest that melatonin can inhibit PCa growth via Sirt1 inhibition.
Our data identified the mitochondrial pro-apoptotic protein Smac ( also known as DIABLO ) as a PARL substrate.
Our data identify a gain-of-function IFIH1 mutation as causing SMS and leading to early arterial calcification and dental inflammation and resorption.
Our data imply the Nogo-a / NgR1 pathway is involved in NPSLE.
Our data indicate a pre-existing telomere deficit in non-clonal hematopoiesis of AML patients providing a link between age and AML development.
Our data indicate distinct selectivity of PBB3 compared to AV-1451 for diverse tau fibril strains.
Our data indicated more pronounced glycation in patients suffering from diabetes as compared to non-diabetics subjects demonstrating the need to focus on developing normoglycemic approaches.
Our data indicated that noncanonical Wnt5a signaling might be overactivated by PGRN deficiency.
Our data indicate that ' age effects ' traverse the resource-rich and resource-limited divide and that future ageing-related findings might be applicable to each setting.
Our data indicate that an impaired EPO response , in the absence of evidence for iron restriction or inflammation , is characteristic of AUE.
Our data indicate that distinct pathways are activated during neural and dopaminergic neuronal differentiation.
Our data indicate that fat depot differences in TL mainly reflect shorter TL of SVF cells.
Our data indicate that nc886 is a putative tumor suppressor and could potentially be used as a diagnostic marker in gastric cancer.
Our data indicate that PINK1 deficiency results in swollen , dysfunctional mitochondria and defective mitophagy , and promotes fibrosis in the aging lung.
Our data indicate that PTEN may provide a potential therapeutic target to ameliorate toxic effects of the ( G4C2 ) n repeat.
Our data indicate that SCA31 is absent or rare in the Chinese population on Taiwan.
Our data indicate that the ER chaperone GRP78 may have therapeutic potential for preventing and / or slowing age-related neurodegeneration.
Our data indicate that there are overall differences in AD among DM , impaired fasting glucose , and normal fasting glucose.
Our data indicate that there is indeed a genetic component that underpins and modulates up to @percent@ of variability of AAO in Italian FTD.
Our data indicate that tHFS positively influences tactile performance.
Our data indicate that T is an independent determinant of QUS at the os calcis and pBMD at the phalanges in elderly Spanish men.
Our data indicate very narrow and specific input-sensitive periods in infant word recognition , with accentuation being effective prior to repetition.
Our data indicate widespread alterations of RNA metabolism are a novel aspect of disease pathogenesis in sIBM.
Our data instead suggests that somatic mtDNA mutations arise primarily from errors that occur during mtDNA replication.
Our data introduce altered MT-kinetochore interactions as a lesion that explains aneuploidy in meiosis-I in older females.
Our data may facilitate establishment of mass screening programs for these disorders in India.
Our data might provide insights into the selective vulnerability of specific neuronal groups in Alzheimer disease.
Our data prove that it is safer than previously thought to operate on the elderly.
Our data provide a strong basis for development of FXR-Gank-based therapy for treatment of patients with hepatoblastoma.
Our data provide important additional phenotypic and biochemical characterization of a previously generated model of PD.
Our data provide mechanistic insight into gene-environmental interaction ( GxE ) in the pathogenesis of PD.
Our data provide preliminary normative values for future investigation of chemosensation in the Chinese population.
Our data provides evidence that genetic studies using polygenic and pleiotropic models can be used to link specific cognitive functions with psychiatric disorders.
Our data provides potentiality that neurodegenerative diseases may be an underlying pathology in certain cases of BPD.
Our data provide support for the hypothesis that expansion of pre-existing mutations is the primary factor contributing to age-related accumulation of mtDNA deletions.
Our data reports risk factors for frailty that have been reported in the past in other population groups.
Our data reveal distinct phenotype associations of chronic p53 targets that underlie specific gene regulatory mechanisms.
Our data revealed age-related changes in brain activity during both components of reward processing.
Our data revealed a significant increase in BMD , bone volume , and biochemical markers of bone formation.
Our data revealed higher ROS levels in HGPS cells compared to age-matched controls.
Our data revealed that iPSCs have a markedly different overall nuclear architecture that may contribute to highly accurate discrimination based on the cell reprogramming status.
Our data revealed that SIRT1 regulates histone acetylation and methylation at the TERT promoter.
Our dataset , interactive figures , and software for computing CEV with flow cytometry data provide a resource for exploring CEV functions.
Our dataset involved males and females and we found significant differences between them.
Our data shed new light on the physiological functions of APP and the interplay between APP processing and proteostasis during brain aging.
Our data show marked gender differences in age experiences , but give little support to claims of a double standard concerning the aging body.
Our data show that BBB leakage is common in dementias.
Our data show that DHA up to @number@ % total dietary fatty acids does not adversely affect growth.
Our data show that EMS inhibited TNF-α-induced MMP-1 expression in a concentration-dependent manner.
Our data show that genetic variants in the NER pathway are potentially predictive of treatment response to oxaliplatin.
Our data show that in the non-pregnant state there is a significant decrease in contractility for both spontaneous and depolarised-induced contractions , with age.
Our data show that it develops with increasing age and is part of the expected degenerative changes in the aging spine.
Our data show that Marf and Mitofusins share an evolutionarily conserved role in mitochondrial transport , cholesterol ester storage and steroid-hormone synthesis.
Our data show that microvascular expression of P-gp and BCRP is strikingly decreased in capCAA-affected vessels but not in AD and control samples.
Our data show that reduced syntactic ability in older adults is associated with decreased FC within dedicated syntax networks.
Our data show that the frequency of centrosome aberrations proportionately increases with age following complex damage causing exposures.
Our data show that the homozygous state of position @number@ in the PRNP is not a risk factor for MSA.
Our data strongly suggest that telomere shortening occurs in the early stages of pancreatic carcinogenesis and progresses with precancerous development.
Our data suggest a high frequency of beta-propeller protein-associated neurodegeneration mutations in the Japanese population.
Our data suggest an important role for MMP-9 in development of hemorrhages in the setting of CAA.
Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors.
Our data suggested that KIBRA might associate with younger AD patients ( ≤74 years ) in a Northern Han Chinese population.
Our data suggested that using autologous OASCs from elderly patients for potential therapeutic purposes might be restricted.
Our data suggested the existence of silent CR1 alleles.
Our data suggest reduced PKC activation and consequently reduced response to lipopolysaccharide ( LPS ) stimulation and cytokine release.
Our data suggests an additional function for HDL in aiding extra-hepatic tissues to eliminate 7KCh by returning 7KFAEs to the liver for bile acid formation.
Our data suggests interventions to promote intestinal motility and mucosal barrier function have the potential to support better health with aging.
Our data suggests that umami is an effective tool for the relief of hypogeusia without the side effects of parasympathomimetic drugs.
Our data suggest that acute dietary nitrate supplementation increases the compensatory vasodilator response to hypoxic exercise in older but not young adults.
Our data suggest that ageing reduces the compensatory vasodilator response to hypoxic exercise via blunted NO signalling.
Our data suggest that aging is associated with a reduction in circulating MAIT cells , accompanied with alterations in subset composition and cytokine profile.
Our data suggest that aldosterone , even within the normal range , may be a biomarker of cardiorenal and metabolic disease.
Our data suggest that , as predicted , sCD200 levels fall under bed rest conditions while sCD200R1 levels rise.
Our data suggest that Aβ peptides represent a novel class of antimicrobial peptides that protect against neurotropic enveloped virus infections such as HSV-1.
Our data suggest that bryostatin-1 and picolog could be useful in anti-aging skincare , and could have applications in tissue engineering and regenerative medicine.
Our data suggest that changes in the expression levels of PCNT in DS subjects may be involved into the molecular mechanism of Down's syndrome.
Our data suggest that CHCHD2 and CHCDH10 mutations are not a relevant cause of PD in Italian population.
Our data suggest that CHIP represents a new pathway for modulating telomerase activity in cancer.
Our data suggest that chronic use of ACK could affect cognitive functions , potentially via altering neuro-metabolic functions in male C57BL / 6J mice.
Our data suggest that expression of the E7 protein is variable in established cervical cancer cell lines including C-33A cells.
Our data suggest that focal cerebral ischemia can induce PSD , and E2 can ameliorate PSD.
Our data suggest that genetic variations of the VDR gene did not play a major role in a Taiwanese PD population.
Our data suggest that hNSCs cross-talk with immune cells.
Our data suggest that in addition to aging effects associated with decline in the number of newly generated cells , mutant α-synuclein reduces MPTP-induced neurogenesis.
Our data suggest that in nondiabetic adults , hypovitaminosis D does not enhance toxicity and accumulation of AGEs.
Our data suggest that long-term cigarette smoking might be a strong risk factor for the development of multiple colorectal cancers in male Lynch syndrome patients.
Our data suggest that miR-127 may function as a tumor suppressor that modulates the oncogene BCL6.
Our data suggest that miR-21 has an important role in the pathogenesis of osteoarthritis and is a potential therapeutic target.
Our data suggest that miR-31 is an important physiological target of HDACi , and that it is an important regulator of senescence relevant to cancer.
Our data suggest that MP modifies an object's contrast against a short-wave background via simple filtration.
Our data suggest that multitasking costs may be particularly dangerous for older adults even during everyday activities such as crossing the street.
Our data suggest that Nrf2 plays an important role in protection against heat shock-induced collagen breakdown in skin.
Our data suggest that particularly specific CpGs that become hypomethylated upon aging are indicative of biological aging.
Our data suggest that patients with a history of prior warfarin use may be safely treated with thrombolytic agents when their INR levels are low.
Our data suggest that PDE5-I might be beneficial to treat age-related detrimental features in a physiological mouse model of aging.
Our data suggest that preservation of mitochondrial function rather than enhancing mitochondrial biogenesis is a characteristic of long-lived families.
Our data suggest that presynaptic SNARE dysfunction forms part of the synaptopathology of AD.
Our data suggest that reductions in waist circumference and blood pressure may promote improvements in elasticity.
Our data suggest that replicative senescence might dramatically impede human mesenchymal stem cell ( MSC ) function via global transcriptional deregulation in response to IL-2.
Our data suggest that the B-cell memory developmental program is implemented during the first 5-6 years of life.
Our data suggest that the decay of platelet mRNAs is slowed by the natural loss of the mRNA surveillance and ribosome rescue factor Pelota.
Our data suggest that the GXXXG motif is crucial for Aβ production , but not for C99 dimerization.
Our data suggest that the invasive treatment strategy is associated with better outcome.
Our data suggest that the polymorphism of IDE is associated with susceptibility to Alzheimer's disease in Han Chinese.
Our data suggest that the posterior pharyngeal wall is thinner and does not constrict to the same extent in older subjects compared with younger individuals.
Our data suggest that these conditions could play a central role in determining consultation for ED.
Our data suggest that tsp-3 is a novel modulator of hypoxic signaling and rcan-1 is a context-specific calcineurin regulator.
Our data suggest the potential use of polydatin in combination chemotherapy for human colon cancer.
Our data suggest the presence of a founder mutation for chromosome 9p21-linked ALS.
Our data supported the recent theory so called \ "adiponectin paradox \ ".
Our data support the clinical observations in humans of strong RPE fluorescence , increasing with age , in the central area of the RPE.
Our data support the hypothesis that mtDNA haplogroups representing populations from different geographic origins may play a role in differential susceptibilities to diseases.
Our data support the important role of time after surgery in considering the influence of biopsychosocial and clinical factors on acute postoperative pain.
Our data support the use of MSE analysis as a validation metric for quantifying the complexity of rs-fMRI signals.
Our data support the use of pre-operative CPET and the application of an intra-operative protective ventilation strategy.
Our data uncover an important physiological function of Huntingtin and provide a missing link in the activation of selective macroautophagy in metazoans.
Our day to day lives are punctuated by work , education , domestic chores , sleep and food.
Our demonstration of a conserved arrestin-dependent transcriptomic signature suggests a framework within which the in vivo outcomes of arrestin-biased signaling may be generalized.
Our Drosophila studies support a role for this synaptotagmin point mutation in disease etiology.
Our dual-task test required the subjects to walk @number@ m while stepping over lines.
Our earlier observations suggest that curcumin's suppression of atherogenesis might be mediated through changes in aP2 and CD36 expression in macrophages.
Our emphasis was on validating an index of allostasis.
Our epigenome alters with aging.
Our eQTL-based approach revealed for the first time that human longevity is associated with a depletion of metabolic pathways in a genotype-dependent and independent manner.
Our eQTL studies support a functional role for two COMMD10 SNPs , since they influence gene expression in both blood cells and lung tissue.
Our ESM study found no difference between the young and the old participants in the judgment of passage of present time.
Our estimates for children aged 0-59 and 24-59 months are consistent with CDC's Immunization Information System sentinel sites data for 2011-2012.
Our evidence indicates that the complex is required for efficient poly ( ADP ) ribosylation of NuMA1.
Our experience suggests that RES can be a safe and effective therapy in well-selected , septuagenarian patients with drug-resistant epilepsy.
Our experience with acute mesenteric ischemia suggests that percutaneous treatment may be an effective alternative to surgical revascularization in appropriately selected patients.
Our experiment results showed erectile function of the aWTR group and aTGRH group was lower compared with those of other two groups.
Our experiments also show that the severe phenotype of Gcp depletion can be relieved under conditions of low intracellular glycation.
Our experiment was carried out on younger and older adults , in whom we also measured inhibitory capacity , working memory , and processing speed.
Our exploration of national policies illustrates different solutions that attempt to promote fairness while stimulating efficient delivery of services.
Our feature selection experiments indicated that joint intensity and texture features produce the highest classification accuracy at @percent@.
Our final future aim is to obtain better results when analyzing medical data.
Our final models suggested that the factors affected the temporal pattern of morbidity differently.
Our final study population consisted of @number@ postmenopausal women.
Our finding also replicated a previous study showing association of rs2252576 with AD.
Our finding might add new information for social networks , social contacts , and cognitive research in the elderly.
Our finding presents pine pollen as an attractive agent with potential to retard aging and attenuate age-related diseases in humans.
Our finding revealed hKLK1 played a protective role in age-related ED.
Our findings add behavioral evidence to the emerging view that healthy aging affects the striatal system before the medial temporal lobes.
Our findings add to the growing volume of evidence supporting cadmium's toxicity even at low levels of exposure.
Our findings add to the inconsistent evidence regarding the association between concurrent BLLs and cognitive function in older adults.
Our findings advance the understanding of the pharmacogenetic architecture of statin response.
Our findings agree with research from other groups ; changes in human gait reflect changes to well-being.
Our findings allow a better understanding on the AD pathophysiologic process and follow-up process of drug treatment even at advanced disease stages.
Our findings also indicate a synergistic effect of animal-derived protein intake and physical activity on muscle-related parameters.
Our findings also indicated that hot stupe application on the epigastrium was effective for improving gastrointestinal motility in elderly individuals.
Our findings also indicate that a simple epigenetic drift model is insufficient to explain all age-related changes in DNA methylation.
Our findings also reveal gender differences in risk taking with age.
Our findings also suggested that the pattern of brain network changes in TBI survivors presented similar functional consequences to normal aging.
Our findings also suggest several novel psychological factors including ineffectiveness as predictors of obesity during adolescence.
Our findings also suggest that attained lifetime education may mitigate aging-related neurocognitive impairment , especially among those born late preterm.
Our findings also support cell-specific effects of age on gene expression , illustrating the importance of using purified cell samples for future transcriptomic studies.
Our findings also underscore the importance of the critical assessment of the biological impact of maternal-fetal conditions in biological studies and clinical applications of hUC-MSCs.
Our findings and the underlying mechanisms should be followed up in further , preferably longitudinal studies.
Our findings and the underlying mechanisms should be followed up in further , preferably longitudinal studies.
Our findings appear that sexual function is associated with sociodemographic characteristics of Iranian middle-aged women.
Our findings are based on a combination of human specimens and an in vivo murine model and may , therefore , translate to clinical care.
Our findings are consistent with previous paradigms demonstrating more diffuse cortical activation during motor tasks in older adults.
Our findings are consistent with the hypothesis that omeprazole reduces melanogenesis by inhibiting ATP7A and by enhancing degradation of tyrosinase.
Our findings are consistent with the literature and support the construct of the study measures.
Our findings are exploratory rather than causal conclusions.
Our findings are in agreement with current clinical practice guidelines for the pharmacological treatment of AD.
Our findings are in line with the results obtained in Iraq and Russia.
Our findings are relevant to the relationships between these cardiovascular biomarkers in the general population but not to cardiovascular disease as a clinical outcome.
Our findings broaden the spectrum of disease associated with alteration of SYNJ1 and further implicate defects in synaptic vesicle recycling in the tauopathies.
Our findings can inform diagnostic approaches to the clinical evaluation of memory complaints in the nondemented elderly.
Our findings cast fresh light on primate evolution and human history , opening directions for research on inequality , sociality , and aging.
Our findings challenge the use of a first-order function to study the influences of the oxygen delivery-utilization balance over the pV̇O2 dynamics.
Our findings challenge the validity of research relying on self-reports of attitudes about older adult sexuality.
Our findings confirmed the presence of autochthonous HEV among people and pigs in Tibet , China.
Our findings confirm measurable degradation of collagen fibrils and associated proteins in old and torn tendons , suggesting a significant loss of tissue organisation.
Our findings confirm the presence of birth cohort effects also in old age but indicate a faster rate of decline in later-born samples.
Our findings connect multimodal genomics data with a commonly used clinical marker of cardiovascular disease.
Our findings could be consistent with either a threshold association of income inequality and mortality or little overall association.
Our findings could be helpful in supporting a proper diagnostic process when evaluating older patients after a fall.
Our findings could be used to develop and pilot test a self-management program for individuals with traumatic SCI.
Our findings counter conceptions of older adults ' autobiographical memories as invariably less episodically rich than those of younger adults.
Our findings demonstrated the importance of implementing smoking prevention programs , to educate older adults who live with a smoking spouse and / or offspring.
Our findings demonstrate that a modest decrement in base excision repair capacity can render the brain more vulnerable to AD-related molecular and cellular alterations.
Our findings demonstrate that Cyn is a potent activator of the AhR-Nrf2-Nqo1 pathway , and could therefore be applied to prevention of UVB-induced photo aging.
Our findings demonstrate that human buccal samples are a valuable tool for studying clock-gene rhythms and the response of PER2 to light.
Our findings demonstrate that migrants have higher levels of depression than nonmigrants , after controlling for selection into migration and risk factors.
Our findings demonstrate that the neural correlates of conscious perception are stable across years for adults , but differ across individuals.
Our findings demonstrate that ubiquitin can act as a signal at five cytodomain-located lysines for endosomal sorting of APP.
Our findings demonstrate the value of information of appearance of gray hair for age estimation in the field of forensic science.
Our findings did not generally indicate that older adults of low socioeconomic status have a reduced capacity to be mobile.
Our findings do not confirm the existence of the first postulated learning stage for the case of adaptation.
Our findings do not suggest that PFASs are associated with poor neuropsychological function.
Our findings do not support the hypothesis that depression symptoms may be a risk factor for cognitive decline in the general population.
Our findings do not support the notion that the pro-tumoural action of BASIGIN is mediated via induction of MMPs.
Our findings emphasise the resourcefulness of these older adults when coping with apparent adversities.
Our findings emphasize the importance of shared knowledge in shaping infants ' emergent communicative skills.
Our findings emphasize the importance of the preoperative of β-cell function for remission of diabetes after RYGB.
Our findings emphasize the need to differentiate between specific aging processes in order to understand functional decline and stability across the adult life span.
Our findings enhanced the understanding about the topological principles of PET networks and changes related to normal aging.
Our findings establish a critical role for TRiC-mediated protein folding in the telomerase pathway and link proteostasis , telomere maintenance , and human disease.
Our findings establish that DG dysfunction is a driver of age-related cognitive decline and suggest non-pharmacological means for its amelioration.
Our findings establish WRAP53β as a novel regulator of DSB repair by providing a scaffold for DNA repair factors.
Our findings expand the understanding of genotype-phenotype correlations in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
Our findings extend the HAROLD model to motor behavior , suggesting that aging results in decrements in motor lateralization.
Our findings have implications in both theoretical and applied contexts.
Our findings have implications in other clinical settings with impaired thymic activity , and are particularly relevant to studies of autoimmunity in ageing.
Our findings have implications in preventing delirium in elderly by an early and targeted evaluation.
Our findings have important implications for both longitudinal assistance and clinical care of demented patients.
Our findings have important implications for the development of DC-based vaccination strategies to potentiate NK-cell responses in patients with cancer.
Our findings have policy implications that include expanding the coverage of the FHS throughout big cities where coverage is limited.
Our findings have uncovered a novel function of MST1 in mRNA and lncRNA translation by direct phosphorylation of eIF4E.
Our findings have wider behavioural implications in these contexts because an enhanced optimistic update bias may skew such real-world decision making.
Our findings highlight a previously unknown link between Akt signaling and telomere protection.
Our findings highlight clinical and policy areas where targeted interventions may delay LTC admissions.
Our findings highlight epigenetic links between aging postmitotic skeletal muscle and DNA methylation.
Our findings highlight personality-related variation that may be related to individual differences in brain structure that merit additional attention in neuroimaging research.
Our findings highlight the importance of gender and age balance in clinical studies and in the development of new treatments and vaccines.
Our findings highlight the importance of paying attention to probable sex differences when assessing and treating early social-emotional / behavior problems.
Our findings highlight the molecular complexity of pathophysiology associated with a deregulated neuro-endocrine system and for developing novel therapeutic strategies for these diseases.
Our findings highlight the need for every patient with new-onset ILD , regardless of age , to be surveyed for exposures and findings of CTD.
Our findings highlight the need for interventions to both identify and support children experiencing socioeconomic or psychosocial of adversity as early as possible.
Our findings highlight the need for large-scale multicenter studies on Indian ALS patients to better understand the underlying genetic causes.
Our findings identified that AdMSCs reduce MMP-1 level in UV-irradiated HDFs and increase type @number@ procollagen in HDFs.
Our findings identified three barriers to accessing health services in prison including psychological obstacles , negative consequences of healthcare utilization , and environmental hurdles.
Our findings identify a novel circuitry between HIF-1α and p53 , and provide a paradigm for HIPK2 dictating cell response to antitumor therapies.
Our findings identify an unexpected crosstalk and integration of the Ral and mTOR signaling networks.
Our findings identify SLC25A24 mutations affecting codon @number@ as the underlying genetic cause of human progeroid Fontaine syndrome.
Our findings implicate attention and working memory processes as critical components of slow movement timing and sources of specific challenges thereof for older adults.
Our findings implicate heritable defects of the SIM1-ARNT2 axis in the predisposition to human obesity.
Our findings implicate that vitamin D supplementation becomes more important in older age groups and during wintertime.
Our findings implicate that vitamin D supplementation becomes more important in older age groups and during wintertime.
Our findings indicate A53T mice develop fine , sensorimotor , and synaptic deficits before the onset of age-related gross motor and cognitive dysfunction.
Our findings indicated that CC tissue loss leads to selective impairment of processing speed but not memory or executive function deficits.
Our findings indicated that our proposed method would also be valid for this purpose.
Our findings indicated that we had established a cell line with its similar phenotype and properties to primary HCECs.
Our findings indicate that aMCI-related performance typically measured at @number@ min underestimates aMCI-associated memory deficits.
Our findings indicate that a strong family network is positively associated with more years of attendance in ADHC , and with higher QOL scores.
Our findings indicate that AUF1 functions in promoting miRNA-mediated mRNA decay globally.
Our findings indicate that CK2 down regulation facilitates TNF-α-mediated chondrocyte death through apoptosis and autophagy.
Our findings indicate that early-life factors may predict inequity during younger adulthood , with environmental factors becoming more important at older ages.
Our findings indicate that expansion size does affect disease severity , which if replicated in other cohorts could be relevant for genetic counselling.
Our findings indicate that HS3ST2 centrally participates to the molecular mechanisms leading the abnormal phosphorylation of tau.
Our findings indicate that increased LTPA results in reduced hospitalization among adults with diabetes.
Our findings indicate that in Iraq , DLBCLs are @percent@ of NHLs.
Our findings indicate that interventions to improve attachment security or coping processes related to attachment could help older adults retain life satisfaction.
Our findings indicate that LIDs in PD are associated with higher GP serotonergic function.
Our findings indicate that MAPT , GRN , and C9orf72 mutations are rare causes of FTD in Korean patients.
Our findings indicate that normal development does not require the C-terminal SH3 domain.
Our findings indicate that Sam68 is required to prevent the expression of p31S6K1 in adipocytes for adipogenesis to occur.
Our findings indicate that the AFE-T is a sensitive test , capable of detecting subtle memory difficulties in PreAD-1.
Our findings indicate that the association between social support and advance care planning was mixed.
Our findings indicate that the bioengineered hair follicles could restore physiological hair functions and could be applicable to surgical treatments for alopecia.
Our findings indicate that the right amygdala networks might be critical in understanding the neural mechanisms underlying LOC's role in cognitive aging.
Our findings indicate that the SAC-RNA CircPVT1 , elevated in dividing cells and reduced in senescent cells , sequesters let-7 to enable a proliferative phenotype.
Our findings indicate that these women's sexual subjectivities were shaped by dominant norms of ageing , sex , and gender.
Our findings largely confirmed the findings of our nontargeted approach that inflammatory glycoproteins are increased with frailty.
Our findings lend some physiological validity to ratings of habitual sleep quality in normal sleepers.
Our findings link hearing loss to decreased biochemical coupling due to the point-mutated Cx30 in mice.
Our findings match the findings of other studies conducted in Guatemala.
Our findings may aid the development of cell-based therapies for tendon repair.
Our findings may also provide essential insights into the diagnostic item of NCD.
Our findings may be applicable to others with chronic disabling conditions who contemplate the user-pay unregulated invasive procedures available to them.
Our findings may contribute to a better understanding of age-related differences in functioning of stress-related systems.
Our findings may explain divergent results on implicit learning tasks in previous studies on aging.
Our findings may explain part of the higher V · E response while walking in older individuals.
Our findings may give direction for tailored interventions for caregivers of persons with dementia , which may improve social health and reduce health care costs.
Our findings may help explaining why a similar amount of exercise exerts significant benefits in preventing cardiovascular events.
Our findings may help to explain crucial A-T features and provide further mechanistic rationale for TNKS inhibition in cancer therapy.
Our findings may help to identify novel targets for the prevention or treatment of hypertension.
Our findings may offer insight when considering the focus of community exercise programs among the elderly.
Our findings may pertain to cancer survivors in general , underlining the importance of extended follow-up.
Our findings may provide new insights into molecular mechanisms mediated by IGF-1 in cell survival against Aβ-induced apoptosis.
Our findings might be valuable in the perspective of developing biomarkers for AD.
Our findings might serve as a reason to adopt a more positive view to ageing in a world with an increasing number of older people.
Our findings partially explain the processes by which older adults work toward their social goals.
Our findings partly support our hypotheses in that obesity-associated changes in GM PCSA and volume differed between the young and old.
Our findings point to a dissociation between episodic processes involved in memory and imagination and nonepisodic processes involved in picture description.
Our findings point to an overall low folic acid supplement use and low plasma folate concentrations among women of reproductive age in Bangladesh.
Our findings point to the needs for healthcare professionals to be more alert of the association of loneliness and adverse health outcomes.
Our findings provide a benchmark for research on brain structural and cognitive changes with aging in East Asians.
Our findings provide a better understanding of the mechanism of cognitive decline in hypertension and highlight the importance of brain protection in hypertension.
Our findings provide a mechanism by which the exocyst function and actin dynamics are modulated for EMT and tumor invasion.
Our findings provided quantitative insights into topological principles of structural brain networks and changes related to normal aging.
Our findings provided the first independent evidence that variants in BIN1 were significantly associated with LOAD in Han Chinese individuals.
Our findings provide evidence for the role of WM microstructure as a scaffold for the context-relevant utilization of GM regions.
Our findings provide evidence that CR has therapeutic potential against poor endometrial receptivity.
Our findings provide insight into the direct biological effects of social inequality on immune function , thus improving our understanding of social gradients in health.
Our findings provide insights into overlapping substrate preferences of ADARs and potential involvement of ADAR1 in BC.
Our findings provide new insights into telomere regulatory mechanism and even pathogenesis of age-related diseases.
Our findings provide not only a novel pathological hallmark in MHE but also a novel target in MHE therapy.
Our findings provide novel information on the pathogenesis of pRCC that allow insights for personalized treatment.
Our findings provide strong evidence that suppression of neuroinflammation could be a promising treatment strategy to preserve cognition during aging.
Our findings provide support for an association in the IDE region on chromosome 10q with Aβ40 and @number@ levels.
Our findings provide the first indications that the effect of light on cognition may be reduced in healthy aging.
Our findings reveal a new AR-mediated mechanism of p53 inhibition that promotes treatment-resistant prostate cancer.
Our findings reveal a novel epigenetic mechanism in aging microglia that contributes to cognitive deficits in aging and neurodegenerative diseases.
Our findings reveal both short- and long-term challenges associated with transitions back home.
Our findings revealed that response to endoplasmic reticulum stress and response to unfolded proteins were ranked top amongst the cellular processes affected by CSB suppression.
Our findings reveal that human cord plasma contains plasticity-enhancing proteins of high translational value for targeting ageing- or disease-associated hippocampal dysfunction.
Our findings reveal that plantar impulse distribution curves for Achilles tendon ruptures change irregularly with subjects ' walking speed changes.
Our findings reveal the role of enhanced emotional regulation abilities as a potential factor associated with the stress-reducing capacity of dispositional mindfulness.
Our findings seem to be driven by abdominal obesity ( as indicated by the waist circumference ) and HDL cholesterol dysregulation.
Our findings should be confirmed in longitudinal studies.
Our findings showed also that Aβ 1-40 and Aβ 1-42 acted directly on HSV-1 in a cell-free system and prevented viral entry into cells.
Our findings showed similarities in HAND and non-HAND groups on both NPI-Q ( items and clusters ) and GDS scores.
Our findings showed that all three groups were mostly concerned with issues around behavior , cost and lack of technical skills.
Our findings showed that lower levels and steeper declines of life satisfaction each uniquely predicted higher mortality risks.
Our findings showed that older adults demonstrate an overall recall deficit which appeared to be a consequence of both an encoding deficit and consolidation weakness.
Our findings show that Apo D expression is influenced by age , Braak stage , and sex.
Our findings show that FCRP can predict the progression of deterioration in AD patients.
Our findings show that health and economic status are by far the most significant predictors of life satisfaction.
Our findings show that KCNJ6 is associated with alcohol dependence and may moderate the effect of early psychosocial stress on risky alcohol drinking in adolescents.
Our findings show that loss-of-function mutations in CKAP2L are a major cause of Filippi syndrome.
Our findings show that PFN1 is a rare cause of ALS and adds further weight to the underlying genetic heterogeneity of this disease.
Our findings show that there are partially overlapping functional networks associated with single- and dual-task walking conditions.
Our findings show that the serum Mn levels are lower in AD patients , and Mn deficiency may be a risk factor for AD.
Our findings show the development of DED in aging mice.
Our findings show the utility of trans-ethnic GWASs for discovery and characterization of genetic loci influencing hematologic traits.
Our findings speak to a contextual approach to everyday problem solving by showing that goals are associated with the selection of problem-solving strategies.
Our findings strongly suggest that persistently elevated Lp-X may cause xanthomas.
Our findings suggest a diminished homeostatic sleep drive in PSP.
Our findings suggest a high prevalence of LT in obese men with LUTS / BPH.
Our findings suggest a possible contribution of Notch4 signalling to the development of brain AVMs in human.
Our findings suggested that depletion of Nrf2 promoted both mRNA expression and activity of MMP-1 in the UVA-irradiated HaCaT cells.
Our findings suggested that individual with DCD lag behind their TD counterparts in kinesthetic sensitivity.
Our findings suggested the necessity of re-evaluating the optimal level of LDL-C among the oldest old.
Our findings suggest HIV providers are more likely to address non-HIV-related healthcare maintenance when HIV is controlled.
Our findings suggest how older women's health and life satisfaction can be improved , and give necessary directions for future studies.
Our findings suggest levels of some apolipoproteins , especially ApoE , are associated with lifespan and cognitive function in exceptionally long-lived individuals.
Our findings suggest multiple underlying pathways that motivate SCD that do not necessarily interact to influence SCD endorsement.
Our findings suggest simultaneous object perception deficits in very early AD , and a visual processing speed reduction underlying these deficits.
Our findings suggest that AAS questions may be interpreted differently by older adults than intended by survey developers.
Our findings suggest that ADC values of normal testicular tissue increase with advancing age.
Our findings suggest that adults with diabetes should be monitored for the development of these conditions beginning at a younger age than previously thought.
Our findings suggest that age-related modulation of performance as a function of the time of the day is specific to resistance to interference.
Our findings suggest that age's association with the disabling fraction of cognitive performance is partially mediated by serum proteins , somatomedins and hormones.
Our findings suggest that aging , in concert with diabetes , exerts an additive effect on OxS and inflammation.
Our findings suggest that apathy is related to poor neuropsychological functioning , HIV plasma levels , and increased functional disability in individuals with HIV.
Our findings suggest that APOE-ε4 may be considered as evolutionarily adaptive.
Our findings suggest that at least acutely , the physiological stress arousal systems and the emotional experience of stress are dissociated.
Our findings suggest that awareness of the perturbation time favored shorter response latencies in both the young and older individuals.
Our findings suggest that baicalein is one of the candidates for the prevention of inflammation-associated colon carcinogenesis.
Our findings suggest that betaine is one of the candidates for the prevention of inflammation-associated colon carcinogenesis.
Our findings suggest that better access to dental care could improve dental care utilization by caregivers.
Our findings suggest that BFCS atrophy is more closely associated with cortical amyloid burden than hippocampus atrophy in predementia AD.
Our findings suggest that bilateral oophorectomy is causally linked to accelerated aging.
Our findings suggest that both \ "amyloid-first \ " and \ "neurodegeneration-first \ " biomarker profile pathways to preclinical AD exist.
Our findings suggest that both biomarkers measure different aspects of AD Aβ pathology.
Our findings suggest that both circulating IGF-1 and LTL are indices of healthy aging in humans.
Our findings suggest that CSB modulates cell viability in pluripotent stem cells , regulating the expression of TP53 and TXNIP and ROS production.
Our findings suggest that CURB65 scores can help clinicians to assess patients with exacerbation of COPD.
Our findings suggest that current economic status is independently associated with cognitive function in adults over age @number@ years.
Our findings suggest that cytomegalovirus infection might be a driving force in the activation of monocytes and is associated with the functional and cognitive decline.
Our findings suggest that delayed age at puberty could potentially be a predictive biomarker for psychopathology in males at risk for schizophrenia.
Our findings suggest that EBV and HHV- @date@ be environmental risk factors for cognitive deterioration and progression to AD in elderly persons.
Our findings suggest that elderly patients with multiple morbidities perceive that their health needs are not being adequately met.
Our findings suggest that future therapeutic strategies should identify new drug combinations and treatment regimens that target all the dysfunctional hallmarks that characterize HGPS cells.
Our findings suggest that general intelligence and global properties of structural brain networks may not be generally associated in cognitively healthy elderly.
Our findings suggest that genetic variation in the CADM2 gene is associated with individual differences in information processing speed.
Our findings suggest that HCH6-1 , a FPR1 antagonist , may have potential as a new therapeutic agent for treating FPR1-involved inflammatory lung diseases.
Our findings suggest that heterozygous GBA mutations are strong risk factors in FPD , especially for autosomal dominant PD.
Our findings suggest that higher intra-couple levels of extraversion predict marital satisfaction , both husbands and wives.
Our findings suggest that IF5 / BTG4 may be an aging-related gene in epithelial cells.
Our findings suggest that immune factors affect seroconversion.
Our findings suggest that increased cortical iron content can be assessed in healthy aging in vivo.
Our findings suggest that increased IMTG during diet-induced moderate weight loss may not be directly related to cardiometabolic risk.
Our findings suggest that increasing SLC16A11 function could be therapeutically beneficial for T2D.
Our findings suggest that intake of whole fruits and vegetables may help improve knee pain in older adults.
Our findings suggest that low-volume physical activity may improve resting oxidative stress status in postmenopausal women.
Our findings suggest that many individuals who were functionally independent were covered under the welfare-placement system.
Our findings suggest that mitochondrial dysfunction may be a potential pathophysiologic mechanism of osteoporosis in postmenopausal women.
Our findings suggest that NF-L protein or mRNA may negatively affect the expression of TDP-43 in the central nervous system.
Our findings suggest that Norwegians and Canadians are not highly individualistic people and also provide evidence of a bicultural self-perception of aging.
Our findings suggest that octogenarians should be included in randomized trials examining CAS to better define the risk-benefit profile of this procedure in the elderly.
Our findings suggest that older adults exhibit a reduced capacity for cross-limb transfer , which may have implications for motor rehabilitation programs after stroke.
Our findings suggest that perceptual speed was more important for buffering age differences in technology ownership than verbal fluency.
Our findings suggest that PFC activation is associated with social functioning in healthy elderly adults.
Our findings suggest that public policies that target childhood wellbeing may have far-reaching protective impacts on health among seniors.
Our findings suggest that quantification of bone marrow FF using MRS might be used as a surrogate biomarker of bone marrow activity in clinical settings.
Our findings suggest that regular physical activity modifies the age-related pattern of decline in physical performance , with greater benefits observed for more intensive activities.
Our findings suggest that sarcopenia may affect inspiratory muscle strength earlier or more than the expiratory muscle strength.
Our findings suggest that SIN can be useful for the treatment of bone diseases associated with over-activity of osteoclasts.
Our findings suggest that spousal caregivers are particularly vulnerable because they have fewer resources to draw on for support and perform much more intensive care.
Our findings suggest that structural alterations of subregional callosal fibers may account for bimanual motor declines in normal aging.
Our findings suggest that sulphonylureas should be used with caution , whereas rapid- and long-acting insulin analogs seem safer.
Our findings suggest that the aging process reduces the explosive grip force-generating capacity before affecting peak force.
Our findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NLRP3 inflammasome.
Our findings suggest that the APOEε2 and APOEε4 alleles produce both convergent and divergent topological effects on brain function.
Our findings suggest that the dietary exposures examined convey limited attributable risk of AF in the general population.
Our findings suggest that the F352V and C370S substitutions lead to alterations in processing as seen by differences in shedding and half-life.
Our findings suggest that the family caregivers who underwent psychosocial intervention achieved better understanding of different symptoms and the behaviors of dementia.
Our findings suggest that the HPV-16 E7 oncoprotein could be a useful marker for the detection of cervical adenocarcinoma and their precursors.
Our findings suggest that the hypertensive group may be sensitive to BP reductions.
Our findings suggest that the induced activation of ACh , rather than basal ACh activity , is associated with superior learning in the aged.
Our findings suggest that the lifetime accrual of sensory experience optimizes functional brain architectures to enable efficient and generalizable predictions of the world.
Our findings suggest that the marker of panel of proteins identified here may be important candidates for improving the earlier detection of AD.
Our findings suggest that the predictors of insight in schizophrenia differ early and later in life.
Our findings suggest that the reduced adulthood cognition associated with childhood exposure to SH is not accompanied by lasting EEG abnormalities.
Our findings suggest that there is a somewhat paradoxical pattern of discrepant late-life change trends in subjective versus objective indicators of health and functioning.
Our findings suggest that the relative intake of lutein and zeaxanthin may be important to age-related macular degeneration risk.
Our findings suggest that these genes warrant further studies of their genetic effects on blood pressure , including pharmacogenetic interactions.
Our findings suggest that these instruments lack the necessary sophistication to capture the complexity of ( unplanned ) readmissions.
Our findings suggest that these sequential modulations may result from executive control mechanisms , the efficiency of which is known to decrease in older adults.
Our findings suggest that this rare variant could be specific to the individuals of the origin from the Nordic countries.
Our findings suggest that understanding brain-behavior relationships in neurological disorders requires examination of large-scale networks , even when dysfunction is relatively focal as in MCI.
Our findings suggest that VISCODERM Pearls is effective for treatment of facial photoaging but further studies in larger cohorts of patients are required.
Our findings suggest that while amyloid-β is sufficient to induce hypometabolism , these pathologies are not linked in a dose-dependent manner in TASTPM mice.
Our findings suggest that young epigenetic age contributes to maintained memory in aging.
Our findings suggest the usefulness of eupatilin for preventing skin aging.
Our findings suggest two types of religiousness : @number@
Our findings support a concept with diverse cis-regulatory variants contributing to disease pathophysiology at one locus.
Our findings support a neuroprotective function of vitamin D on motoneurons and propose vitamin D as a reliable prognostic factor of ALS.
Our findings support an oligogenic basis with the burden of rare variants affecting the development and survival of ALS.
Our findings support consistency of gait measurements during the earliest stages of disability.
Our findings support the hypothesis that cellular pathways that regulate aging are sex specific.
Our findings support the hypothesis that muscle mass and function are associated with BMI and physical activity , whatever the age of the subject.
Our findings support the notion of biosocial pathways playing an important role in shaping the fertility-health nexus.
Our findings support the notion that cerebellar volume has an influence on cognition in aging , but that it is not the major leading structure.
Our findings support the use of multifractal analysis to assess aging-related microvascular dysfunction.
Our findings support the use of progressive resistance training for untrained older adults to improve balance.
Our findings support the use of regional brain atrophy as a preclinical biomarker for LOAD among at-risk individuals.
Our findings support the use of the proposed research criteria to identify Alzheimer's disease at the mild cognitive impairment stage.
Our findings support using the mHELP to advance postoperative care for older patients undergoing major abdominal surgery.
Our findings therefore suggest that CSH is part of a generalized autonomic disorder but do not differentiate between asymptomatic and symptomatic individuals.
Our findings therefore suggest that Srxn1 may represent a therapeutic target for neurodegenerative disorders such as PD that involve nitrosative / oxidative stress.
Our findings thus indicate that despite increases in circulating sclerostin levels , bone sclerostin mRNA levels do not increase in elderly women.
Our finding suggests that this area plays an important role in defining an individual's trait associated with reflectivity and impulsivity.
Our findings uncover a novel mechanism by which AUF1 binding and transfer of microRNA let-7 to AGO2 facilitates let-7-elicited gene silencing.
Our findings uncover a specific mechanism of telomeres that surmounts the unique challenges of mammalian X-Y pairing in meiosis.
Our findings uncovered an unanticipated role of IRE1 in the pathogenesis of AD , offering a novel target for disease intervention.
Our findings underline an increasing need for SCC treatment in Norway , especially considering the aging population.
Our findings underline need to move forward from and overcome shortcomings of gFOBT-based colorectal cancer screening.
Our findings underpin the importance of exercising without the fear that becoming exhausted might be bad for one's health.
Our findings underscore the large proportion of AMD cases explained by genetics particularly for younger AMD patients.
Our findings underscore the need for investigating interactive effects of multiple genes to understand individual difference in episodic memory.
Our findings underscore the significance of the timing of the transition to parenthood in specifying the associations between childhood disadvantage and adult heart problems.
Our finding supports the hypothesis that ATXN2 plays an important role in the pathogenesis of ALS.
Our findings warrant clinical evaluation of PIM kinase inhibitors in patients with TN tumors that have elevated MYC expression.
Our findings warrant further consideration of longitudinal cortical thinning as a potential imaging marker to differentiate DLB from AD.
Our findings were consistent with ε4 being a risk factor for early mortality.
Our fMRI results could not be attributed to changes in task performance , group differences in cerebral perfusion , or regional cortical atrophy.
Our focus in this paper is therefore to keep the model and its inference as simple as possible while allowing to capture expected biological variation.
Our focus is on driving , cooking and paying bills , with a prediction that most carers ' concern would be over driving.
Our frailty score provides a tool to evaluate interventions in mice prior to translating them to clinical practice.
Our framework also provides a methodology to assess the effects of different life expectancy distributions on lifetime cancer incidence.
Our framework enables systematic inference of CRE rearrangements mediating dysregulation in cancer.
Our framework remained robust when applied to a routine clinical population.
Our fully isogenic system therefore opens possibilities for modeling mechanisms of developmental , accelerated ageing , and neurodegenerative pathologies caused by T21.
Our functional studies implicate a novel role for STXBP5 and STX2 in regulating tPA release.
Our future research agenda should investigate how reproduction affects health and how health affects reproduction.
Our genetic linkage analysis suggests that the locus for the pink-eyed dilution phenotype of NCT is tightly linked to the Oca2 locus.
Our global increased longevity increases the number of elderly worldwide.
Our global measure of cognition was the Consortium to Establish a Registry in Alzheimer's disease Total Score ( CERAD TS ) .
Our goal is to accelerate the conversation around how we can move towards more translative preclinical work.
Our goal is to describe the association between these two entities in the elderly.
Our goal is to examine the emotional influence of perceived basic motions on cognitive processes in childhood.
Our goal is to provide the most up to date knowledge of respiratory viral infections in our aging transplant population.
Our goal was to demonstrate PST implementation feasibility and to identify PST's potential for reducing depressive symptoms in this geriatric health care setting.
Our goal was to determine the upper limit of normal for number of globally sclerotic glomeruli.
Our goal was to develop a predictive tool using variables available at admission to predict outcomes related to severity of brain injury in aging patients.
Our goal was to elucidate if there were age-related changes on primary hLFs isolated from IPF lungs compared with age-matched controls.
Our goal was to evolve the LAR procedure to optimize its utility in clinical practice and translational research.
Our goal was to extend this recommendation specifically to a well-characterized aging population.
Our goal was to implement a specialty clinic managed by advanced practice nurses to assess and manage behavioral symptoms associated with dementia.
Our goal was to introduce and validate polarization optical imaging for noninvasive quantitative evaluation of dermal collagen.
Our goal was to investigate processes that underlie interindividual variability in age-related changes in the brain.
Our goal was to investigate these memory processes in PD and determine whether the inconsistency among existing findings is related to differences in encoding conditions.
Our goal was to perform a precise investigation of the effects of Age , Sex and Hemisphere on HC / AG volumes throughout aging.
Our goal was to test whether BDNF single nucleotide polymorphisms ( SNPs ) impact Alzheimer's Disease-related brain imaging and cognitive markers of disease.
Our goal was to validate this by determining whether severely injured trauma patients with complicated outcomes have evidence of PICS at the genomic level.
Our group has also demonstrated that Obesity and CD are also highly interconnected.
Our group of research has provided an overall view of the internal temporal order of circadian rhythms in human adipose tissue.
Our health and care services face a number of challenges in @number@
Our healthy control group did not show a priming tendency , presumably due to cognitive interference between declarative and nondeclarative memory.
Our homo-dimeric structure of the CIDE-N domain of FSP27 will provide important information that will enable better understanding of the function of FSP27.
Our hypothesis , based on previous studies , is that aged persons will show differences in one or more of the attributes of sensorimotor performance.
Our hypothesis is supported by recent data reporting expedited AD pathology in presymptomatic transgenic AD mice subjected to TBI.
Our hypothesis is that the shape variations in the infinite-dimensional diffeomorphic metric space can be captured by a low-dimensional space.
Our hypothesis suggests the importance of investigating compounds that are routine dietary components and do not necessarily contain RSV.
Our hypothesis , therefore , offers unique perspective into what sporadic , late-onset AD is and how to best treat it.
Our hypothesis was that school-age children would not treat MC stimuli as navigational paths , assimilating them to reaching sequences.
Our illustrative results show the promise of the proposed system and further studies are expected to validate its performance with quantitative measures.
Our immunoblotting and immunostaining analyses revealed that Aβ and Drp1 levels were reduced in DDQ-treated AD neurons.
Our increased understanding of TREM2 and microglia has opened new avenues for therapeutic intervention to delay or prevent the progression of AD.
Our index test was any single screening question for cognitive impairment , including factor analysis of multi-item tools.
Our initial search yielded @number@ articles.
Our innovation includes applying the intervention to a targeted high-risk population , aiming to provide the best value for money.
Our intensive mentoring program model is replicable in other AIDS Education and Training Centers and in other structured training programs.
Our interdisciplinary approach , which included rank indices and geospatial modelling , can help integrate diverse datasets into evidence-based policy.
Our intervention during one year involved tailored nutritional guidance for these couples.
Our investigation using GC treatments with clinically relevant timing highlights mechanisms underlying GR actions for modulating the \ "inflamed epigenome. \ "
Our in vitro study indicated that FO significantly enhanced the concentration of pro-collagen type @number@ than the EO , by increasing the TGF-β1 production.
Our journey has just begun.
Our key findings were threefold.
Our laboratory has developed fluorescent reporter constructs that allow sensitive and quantitative measurement of NHEJ and HR.
Our laboratory has reported that Aβ , glutamate , and lactic acid are each increasingly toxic with neuron age.
Our large and well-matched sample included @number@ normally developing subjects ( @number@ males , @number@ females ) ranging from @number@ to @number@ years of age.
Our literature review revealed a lack of discussion about using combination codes in analysis.
Our literature review revealed several double-blind , sham-controlled studies , all showing sustained improvement in cognition of AD patients with rTMS.
Our longitudinal analyses demonstrate that PD and parkinsonism are modestly heritable.
Our longitudinal follow-up will allow us to further elucidate this relationship.
Our main continuous measure of renal outcome was change in estimated glomerular filtration rate ( eGFR ) .
Our main findings were twofold.
Our major finding is that repeated very intense exercise prolongs life span in well trained practitioners.
Our management relies on early endoscopic examinations , which are highly available , safe , and accurate.
Our measure of financial extravagance was based on the novelty seeking subscales of the Japanese version of the Temperament and Character Inventory.
Our measure of relative poverty was based upon the standard @percent@ of median income.
Our mechanism suggests focal sevoflurane-induced sequestration of age-related acrolein leading to SDM synthesis and neuronal impairment , which is prevented by L-carnosine.
Our meta-analysis included @number@ studies ( published between @number@ and @number@ ) with a combined sample size of @number@ people with autism and @number@ controls.
Our meta-analysis underscores the need for frequent monitoring of creatinine and calcium levels during cinacalcet treatment.
Our method also provides a way to study a cross phenotype ( CP ) association by using summary statistics from GWASs of multiple phenotypes.
Our method detected significant positive or negative cohort effects.
Our methodology and findings are likely to be highly relevant to health planners and researchers in other countries with aging populations.
Our methodology , capable of overcoming technical and genetic background differences , identified an age-regulation in four of the tissues.
Our methodology is based on content analysis of @number@ semi-structured interviews with seniors and their children.
Our methodology should be broadly applicable for epigenomic comparisons and provides a powerful new tool for studying chromatin state differences at the genome scale.
Our methodology uncovers substantial heterogeneity in expected longevities , yet much less heterogeneity than what arises from the naive application of life expectancy formulae.
Our method provides an epigenetic biomarker to determine the state of senescence in cell preparations.
Our method requires the absence of time-varying confounding with respect to the exposure and the mediator.
Our methods can be used to harmonize neuropsychological test results across diverse settings and studies.
Our method showed improved accuracy for all data samples.
Our method will speed up the research on visual system and greatly enhance studies of different vision-related diseases.
Our model allows us to generate normal values and ranges for ovarian volume throughout life.
Our model also implies a relationship between growth rate and the general process of aging.
Our model claims that the two arms of UPR accomplish an altered upregulation of autophagy and apoptosis inducers during ER stress.
Our model considers the role of both motor development and motor learning in refining feed-forward and online control.
Our model explained @percent@ of the variance in cognitive function after one year.
Our model implements flexible weighting scheme for model rigidity under a multi-level neighborhood for vertex connectivity.
Our modeling approach was based on generalized estimating equation ( GEE ) for self-rated health and Cox proportional hazards models for mortality.
Our model provides a mechanistic explanation how increased stem cell proliferation can lead to progeroid phenotypes.
Our model provides multiple testable predictions , and suggests that different temporal sequences of oncogenic mutations can lead to tumorigenesis.
Our models also estimate the increased radiation-associated mutation rate at a younger age in atomic bomb survivors.
Our models covary for several individual and cohort differences in central indicators of life expectancy , education , health , and gender.
Our model shows that AD is characterized by localized disease-specific brain changes as well as by an accelerated global aging process.
Our models mimic axon developmental defect and the adult-onset degeneration of motor neurons in ALS.
Our model suggests fundamentally new mechanisms that regulate aggregation and deformability in a latch-like manner.
Our models were informed by published data from the United States on influenza complication probabilities and relevant costs.
Our most striking finding was that almost four-fifths of our cases involved women.
Our multimodal intervention lasted @number@ months.
Our national cross-sectional survey included @number@ elderly Malaysian demented subjects.
Our nation can and should do more to help family caregivers provide care in the home to their loved ones who suffer from dementia.
Our natural body odor goes through several stages of age-dependent changes in chemical composition as we grow older.
Our newly established reference ranges for PV and annual PV change rate will be valuable in interpreting PV data in Korean men.
Our new scoring is thus simple and reliable in evaluating dysphagia severity and features , and potentially clinically advantageous.
Our novel PAP grading scale may help objectify and categorize this syndrome.
Our novel results collectively suggest that TRIM32 sensitizes TNFα-induced apoptosis by antagonizing XIAP , an anti-apoptotic downstream effector of TNFα signaling.
Our objective has been to assess the prevalence of primary and central hypogonadism in elderly male patients admitted to the hospital because of acute illness.
Our objective here is to identify the prevalence and predictors of successful cognitive aging ( SCA ) in a sample of older adults with HIV.
Our objective is to determine whether BMI continues to correlate with %BF as women age.
Our objective is to find a potential way or condition for augmenting IL-10 by monocytes / macrophages in vivo and in vitro.
Our objective is to identify factors that create DCW empowerment as this has not received adequate attention.
Our objective is to investigate a potential association between orthostatic blood pressure response and subjective sleep quality in older people.
Our objective is to provide an interface for non-bioinformaticians aiming to acquire ( or contrast ) mtDNA annotations via MToolBox.
Our objectives were to assess quality of surgical care delivered to elderly patients and to determine the association between patient characteristics and quality of care.
Our objectives were to assess serum levels of retinol and zinc among the elderly individuals and to correlate the levels with hearing threshold.
Our objective was to assess how practitioners measure the geriatric syndrome of frailty in their daily routine.
Our objective was to assess the association between LOH and endothelial dysfunction in patients with vasculogenic ED.
Our objective was to assess the changes in distribution of renal disease under antiretroviral therapy ( ART ) .
Our objective was to assess the relation between protein intake and incident 1-y weight loss ≥5% in community-dwelling older adults.
Our objective was to assess whether male and female sex hormones are associated with J point amplitude in healthy subjects.
Our objective was to calculate the number of hospital admissions that will be necessitated by population aging , ceteris paribus.
Our objective was to compare muscle anabolic responses to a single bolus intake of whey or casein after performance of heavy resistance exercise.
Our objective was to compare the two types of DPOAE to track subtle changes due to aging.
Our objective was to describe amyotrophic lateral sclerosis ( ALS ) mortality rates in the Chilean population over a 17-year period.
Our objective was to determine if differences in rates of adherence and tolerability exist among new users to acetylcholinesterase inhibitors ( AChEI's ) .
Our objective was to determine if the major royal jelly proteins ( MRJPs ) extracted from RJ can improve the spatial memory of aged rats.
Our objective was to determine renal function in patients with primary osteoporosis ( type @number@ ) and its relationship with BMD.
Our objective was to determine the association between physiological variations in osteocalcin and the pituitary-gonadal axis in older men.
Our objective was to determine the effect of age on the impact of MUS and MES on HRQoL.
Our objective was to determine the prevalence of functional disability among community-dwelling older women with FI.
Our objective was to determine whether SHS exposure among smokers yields detectable differences in cotinine levels compared with unexposed smokers at the population level.
Our objective was to determine whether the atrophic posterior IFC is differentially recruited for the processing of syntactically complex sentences in nonfluent PPA.
Our objective was to determine whether there is a time-dependent effect of THS exposure on health.
Our objective was to develop and validate a robust subject-specific one-dimensional wave propagation numerical model of the descending aorta.
Our objective was to elucidate the clinical correlates of conversion to dementia in a longitudinal population-based sample.
Our objective was to estimate the effect of overweight and obesity on the use and cost of allied health services among middle-aged and older people.
Our objective was to evaluate the effects of high-dose isoflavones on metabolic and inflammatory parameters in men undergoing ADT.
Our objective was to evaluate the relationship between antemortem MRI measures of entorhinal cortex thickness and postmortem neuropathological measures.
Our objective was to evaluate the utility of plasma glycated albumin ( GA ) in the diagnosis of diabetes mellitus.
Our objective was to examine changes in sleep duration from @number@ to @number@ among US adults.
Our objective was to examine changes over time in @number@ quality metrics available from the registry.
Our objective was to examine the association between depression and health service utilization from age 70-85.
Our objective was to examine the influence of adult and childhood socioeconomic status ( SES ) on attained adult food intake patterns.
Our objective was to examine the longitudinal association between self-reported pain and the development , or worsening , of frailty among older men and women.
Our objective was to explore HIV-infected patients ' perspectives on psychological aspects of chronic pain using in-depth qualitative interviews.
Our objective was to identify demographic , behavioral , and temporal predictors of urinary phthalate metabolite concentrations in young children.
Our objective was to identify longitudinal predictors of frailty severity and mortality among a group aging with HIV.
Our objective was to identify predictors for treatment outcomes after home-based constraint-induced therapy ( CIT ) in children with cerebral palsy ( CP ) .
Our objective was to identify the correlates of age-related differences in BMD among men and women.
Our objective was to increase our understanding of the role of brain lipids in pathophysiology of aging and age-related cognitive impairment.
Our objective was to pilot test a communication protocol ( 'BRIDGE - BRinging Inter-Disciplinary Guidelines to Elders' ) in conjunction with DCM.
Our objective was to prospectively and longitudinally examine associations between methylation of four inflammatory genes and cancer risk.
Our objective was to quantify the risk of gait decline and disability associated with the APOE ε4 allele in aging.
Our objective was to systematically assess the contribution of genetic variation to gait speed in older individuals.
Our objective was to test the hypothesis that a composite index of inflammatory burden is associated with PAD.
Our objective was to use PCA to compare the gait patterns between young and older adults during stair climbing.
Our observations have important implications for improving healthy aging in humans.
Our observations lead to the hypothesis that free thiol β2GPI may protect against oxidative stress injury to RPE cells in the early stages of AMD.
Our observations lead to the hypothesis that higher systemic oxidative stress increases the risk of developing age-related cataract.
Our observations provide direct evidence that dys-regulated basal NF-κB activity may contribute to the mild pro-inflammatory state of aging.
Our observations recommend DNA-PKcs inhibition as a therapeutic concept for the treatment of human cancers displaying homologous recombination defects.
Our observations serve as a basis for etiological stratification and definition of progression patterns of ARTAG.
Our observations show that HUCB neuroprotection is dependent on the activation of the Akt signaling pathway that increases transcription of the Prdx5 gene.
Our observations suggested that re-expressing AR suppresses migration and invasion of PC-3 cells via regulation of EMT marker proteins and MMP activity.
Our observations suggest that there is an association between SDB and CSF Alzheimer's disease-biomarkers in cognitively normal elderly individuals.
Our observations support previous experimental evidence of a possible beneficial relationship between increased flavonol intake and risk of T2D.
Our open vocabulary DLA approach finds words , phrases , and topics that distinguish groups of people based on @number@ or more characteristics.
Our outcomes are change in cognitive function score ( executive and memory ) , cerebral blood flow , and carbon dioxide cerebral vasoreactivity.
Our outcomes suggest that the so-obtained risk factors have to be considered when positioning a ureteral stent.
Our overexpression and knockdown experiments demonstrate that TRIM32 sensitizes cells to TNFα-induced apoptosis.
Our own work has consistently shown abnormal posterior cingulate cortex function following traumatic brain injury , which predicts attentional impairments.
Our paper addresses this shortcoming by comparing prospective and retrospective time estimation in younger adults , older adults , and AD patients.
Our paper investigated this issue specifically for destination memory , that is , memory of the destination of previously relayed information.
Our paradigm indicates how cellular physiology can subtly change in different contexts and potentially aid the appreciation of stress response adaptations.
Our participants are from random selection of @number@ men , aged 20-29 years , and @number@ men , aged 60-74 years.
Our participatory action project introduced mental health huddles to support staff in discussing and managing client-responsive behaviours in long-term care.
Our patient population was preferentially treated with radiation therapy rather than radical prostatectomy.
Our patients demonstrated levodopa-responsive parkinsonism with intrafamilial clinical heterogeneity.
Our patient shows striking similarity to two patients who have been published in this journal by O'Neill et al.
Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber , an endophenotype of the microcirculation associated with clinical cardiovascular disease.
Our population ( n = @number@ patients ) was divided into NLR quartiles.
Our power simulations could be used in conjunction with previous design guidelines in the literature when planning new gait variability experiments.
Our practice has long been concerned with the effects of display quality , including color accuracy and matching among paired color displays.
Our preferred estimate , employing an empirically-matched group of control states , finds that PFL reduced nursing home usage by about @number@ percentage points.
Our preliminary data also demonstrated extremely low frequencies of the apolipoprotein E4 allele in supercentenarians.
Our preliminary data suggest that elevated basal levels of autophagy as reflected by high serum beclin-1 levels may be a biomarker of healthy human EL.
Our preliminary findings suggested nonlinear concurrent cognitive stimulation in the elderly.
Our preliminary study suggests that the cognitive profile of Vasc-MCI is more heterogeneous than previously suggested.
Our present exposition articulates and recounts his many contributions to our science and to science in general beyond the confines of our own discipline.
Our previous data demonstrated that the endonuclease complex ERCC1-XPF , which cleaves a @number@ DNA flap structure , limits L1 retrotransposition.
Our previous data showed that a negative regulation element lies in its promoter.
Our previous studies demonstrated that red wine-related flavonoids with a flavone backbone are able to inhibit Aβ assembly and destabilize preformed Aβ aggregates.
Our previous studies demonstrated that treatment of human glomerular mesangial cells ( GMCs ) with angiotensin II ( AngII ) caused cell senescence.
Our previous studies have confirmed the therapeutic effects of mesenchymal stem cell ( MSC ) monolayer sheet transplantation on allograft repair.
Our previous study demonstrated that enzyme-modified ginseng extract ( EG ) has inhibitory effects against ultraviolet B ( UVB ) radiation-induced skin aging.
Our previous study demonstrated that eupatilin specifically activates peroxisome proliferator-activated receptor alpha ( PPARα ) through direct binding.
Our previous study first demonstrated that CK2 is involved in apoptosis of rat articular chondrocytes.
Our previous study found that cathepsin D decreased in chronic photodamaged skin.
Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells.
Our previous study has shown that NaDC3 promotes cellular senescence , but its mechanism is not clear.
Our previous study reported that cathepsin L may contribute to the death of dopaminergic neurons in rodent model of Parkinson's disease ( PD ) .
Our previous work has shown that neuronal deletion of the Lrp1 gene in mice leads to decreased level of GluA1 and reduced long-term potentiation.
Our previous works have presented that the postural control during standing and cardiovascular changes are related to each other in the health young individuals.
Our primary aim was to determine if higher frailty scores were associated with higher risk of mortality for elderly burn patients.
Our primary analysis was an association with neuritic plaque pathology.
Our primary independent variable was the mean of all HbA1c measurements in the year preceding the survey.
Our primary objective was to determine whether pre-admission CFS is associated with adverse discharge destination.
Our primary outcome was change in a validated , urinary symptom-scale score , such as the AUA / IPSS.
Our primary outcome was successful treatment without need of surgery and discharge home alive.
Our primary purpose in this study was to examine age differences in using choice deferral when young and older adults made trade-off decisions.
Our primary purpose was to determine , using a case-control design , if the ApoE gene is associated with EL.
Our profession is ill prepared to optimally care for this patient population.
Our programme proposes exercises of progressively increasing difficulty that are targeted at daily life situations.
Our program of caregiving research spans two decades , moving from inductive theory development using grounded theory methods to deductive theory testing.
Our projections and simulations map the likely evolution of GMS cost , given existing policies and demographic trends.
Our promising findings underline the great clinical and practical potential of a tablet-based application for detection and monitoring of cognitive dysfunction.
Our proposed intestinal food residue reduction scheme is an original contribution of this work.
Our proposed measures were certified using the calculated arterial stiffness indices.
Our proteomic approach implies that prohibitin in the RPE and the retina could be a new biomarker protein of oxidative stress in aging and diabetes.
Our proteomic approach provided a protein profile predictive of therapeutic effects of sarpogrelate.
Our proteomic , phosphoproteomic and interactome study in the Drosophila brain provides a systematic analyses of R1441C hLRRK2-induced pathobiological mechanisms in this model.
Our proteomic study shows that prohibitin is involved in oxidative stress signaling in the retina and RPE.
Our protocol was designed to minimize limitations faced by previous initiatives , and to enable design-based neurostereological analyses.
Our purpose in conducting this qualitative study was to examine how a multiethnic sample of women living in Hilo , Hawai'i , describe menopause.
Our purpose is to determine whether outcomes and complications are significantly different in the elderly.
Our purpose is to review fracture liaison service ( FLS ) models and to evaluate national and international experiences in secondary fracture prevention.
Our purpose , therefore , was to determine the neural adaptation of multiple motor units and related improvements in movement control following practice.
Our purpose was to confirm the association between skin wrinkling and airflow obstruction and to identify genetic polymorphisms indicative of an underlying susceptibility.
Our purpose was to construct a simple and reliable prognostic scale not requiring the use of a calculating machine.
Our purpose was to evaluate changes in leg spring stiffness and maximum power following eccentric and concentric cycling training.
Our purpose was to explore an optimal or more reliable anthropometric indicator and optimal cut-off points for obesity on metabolic syndrome in Chinese adults.
Our purpose was to investigate the efficacy , safety , and survival of patients ≥ @number@ years old treated with definitive lung SBRT.
Our purpose was to investigate the linkage of quality of care to long-term care placement and survival.
Our purpose was to investigate whether visceral fat promotes a decrease in skeletal muscle mass and vice versa.
Our purpose was to review the impact of age on the prognosis of patients with community-acquired pneumonia ( CAP ) .
Our purpose was to test the multi-action plan model assumptions in which athletes ' psychophysiological patterns differ among optimal and suboptimal performance experiences.
Our qRT-PCR and immunoblotting analysis revealed that reduced levels of mitochondrial fission and increased fusion , biogenesis and synaptic genes in DDQ-treated AD neurons.
Our qualitative study identified pain descriptors and defined seven dimensions of osteoarthritis pain.
Our quantitative analysis of longevity factors and their genetic interactions provides insights into the gene-network interactions of aging cells.
Our ranking suggests that vascular aging , led by ischemic heart disease and stroke , is the most important focus for aging research.
Our reasoning was founded on the assumption that , with age , some of the existing patterns can be destabilized or even lost.
Our recent epidemiological and in vivo data suggest that carbohydrate quality can be a major determinant in prolonging eye health.
Our recent findings indicate that ATR and ATM modulate WRN function at defined steps of the response to replication fork arrest.
Our recent investigation identified short-term white matter integrity ( WMI ) changes in @number@ subjects soon after the Japanese earthquake.
Our recent studies highlight the effect of a biomarine compound ( LD-1227 ) on MMPs , collagen metabolism and on chondrocyte inflammatory markers.
Our recent study demonstrated that cognitive function was more strongly affected by changes in cerebral metabolism than by changes in CBF during exercise.
Our recent study has shown that @percent@ of test subjects over @number@ years of age exhibited hypogeusia.
Our recent study involving AD mice with DM has revealed that a vicious circle underlies the interaction between AD and DM.
Our recent work in mouse and guinea pig has challenged that view.
Our reference standards included clinical diagnosis and multi-domain cognitive assessments.
Our regression forest model used these features to learn a mapping from age-related sonographic image patterns to fetal age and development.
Our research findings show that longevity is more important than birth rate and migration in shaping the degree of deep aging in the research region.
Our research focus has been on the role of IL-21 and more recently of Tfh in immunopathogenesis of HIV infection.
Our research shows that while chronological ageing has clear effects on skin wound healing , falling estrogen levels are the principle mediator of these effects.
Our research will contribute to identifying clinical diagnostic markers and therapeutic targets in the treatment of GBM by postoperative radiotherapy.
Our result confirms the multidimensional nature of the test and the major role of executive functions on performance.
Our results additionally implicate p53 and loss of acetylation homeostasis in the neurodegenerative process.
Our results add to the evidence of the benefit of personnel support in reducing levels of stress at work.
Our results add to the mounting evidence for the critical role of numeracy in decision making across decision domains and across the lifespan.
Our results also demonstrate that serum MLT levels are correlated with severity of PD according to H & Y scale.
Our results also highlight the importance of maintaining a healthy metabolic profile during midlife.
Our results also illustrate that shifts in NFR-thresholds do not necessarily correlate to the modulation of experienced pain.
Our results also indicated that the role of age and cognitive mechanisms in explaining MW depends on the demands of the SART task considered.
Our results also resembled some findings from similar studies in other countries.
Our results also reveal a direct relationship between the expression of telomerase , telomere length and the efficiency of tissue regeneration.
Our results also reveal the mechanism of fat accumulation and redistribution during aging of males and females.
Our results also suggest that location information may be less effortfully processed as compared to identity information.
Our results are also consistent with evolutionary models of aging and thus oppose both somatic mutation-centric paradigms of carcinogenesis and tissue functional decline.
Our results are consistent with early transcellular propagation of tau seeds that triggers subsequent development of neuropathology.
Our results are consistent with LTL being a biomarker of cardiovascular aging through established physiological mechanisms.
Our results are consistent with other studies and standardization of treatment protocols using functional imaging may be of benefit.
Our results are consistent with previous findings that the unique hues are rather constant with age while chromatic sensitivity declines.
Our results are consistent with the €4 allele influencing the effects of psychological trauma on the brain , thereby affecting the risk of PTSD.
Our results are contrary to this perception.
Our results are in accordance with literature ( @number@ counter-lateral subclavian vein and @number@ counter-lateral internal jugular vein misplacements ) .
Our results are in line with previous test-retest studies of [ ( @number@ ) C ] raclopride binding in the striatum.
Our results are in line with the recently reported association between FTO and reduced brain volume in cognitively healthy subjects.
Our results are reaffirmed using an instrumental variable approach and are consistent throughout a range of robustness tests.
Our results are significant and provide empirical evidence about the usefulness of the cognitive frailty concept.
Our results build upon prior findings that policies to prevent the onset of obesity during adolescence be targeted towards girls from lower socio-economic position households.
Our results can be taken to offer further support for the @number@ mg / L discriminant limit for GHB administration in antemortem urine samples.
Our results can be used to predict the transmission of disease-causing mtDNA variants and illuminate evolutionary dynamics of the mitochondrial genome.
Our results clarified the available controversies regarding the role of rs6265 in AD and indicated that BDNF may be a female-specific risk gene for AD.
Our results clarify the aging signaling pathway regulated by NaDC3.
Our results confirm and extend previous extreme-group based findings about specific deficits in error detection associated with higher age using age as a continuous predictor.
Our results confirmed lymphopenia and a deficiency in naive T and B cells in A-T patients.
Our results confirm that MATR3 variants are associated with ALS and suggest that they are more frequent in Italian ALS patients.
Our results confirm that resting-state functional magnetic resonance imaging signals in the sensori-motor network are suppressed in amyotrophic lateral sclerosis.
Our results confirm the high prevalence of neuropathological diagnosis in older adults and the mismatch between clinical and neuropathological diagnoses.
Our results confirm the limited validity of self-reported OLD in epidemiological studies.
Our results confirm the strong implication of BOLD variance in aging and give an initial insight in its relationship with functional connectivity in the DMN.
Our results constitute a strong argument in favor of kidney transplantation , regardless of the patient's age.
Our results contribute to molecular understanding of the competitive interactions of drebrin and cofilin with actin filaments.
Our results corroborate and extend initial reports that self-esteem is , on average , fairly stable into the last years of life.
Our results defined the precise spectrum of light retinal toxicity in physiological irradiance conditions on an in vitro model of age-related macular degeneration.
Our results demonstrate a p97 complex regulating translocation into the ER in a signal-peptide-dependent manner.
Our results demonstrate a reduction in TLR1 expression and TLR1-mediated responses in PMN with aging , and reduced efficiency of bioenergetics in PMN.
Our results demonstrate broad-based benefits of vision in a healthy adult population.
Our results demonstrated that p53 / p21 pathway played an important role in the senescence process of BM-MSCs from SLE.
Our results demonstrated that permeability was significantly higher in colonic biopsies collected from old baboons compared with young baboons.
Our results demonstrated that SIN has an inhibitory effect on osteoclast differentiation through mechanisms involving the inhibition of the PGE2-induced OPG / RANKL ratio.
Our results demonstrated that Sirt1 deficiency led to severe lung inflammatory injury.
Our results demonstrated the stimulators increased activation of primordial follicles and the production of progeny.
Our results demonstrate neurophysiological signatures of network-specific neuronal dysfunction in primary progressive aphasia variants.
Our results demonstrate significantly lower WM integrity in DS compared with controls , particularly in the frontal tracts.
Our results demonstrate that aging is associated with higher DT costs when EFEs are identified concurrently with a visuo-spatial task.
Our results demonstrate that ApoE affects tau pathogenesis , neuroinflammation , and tau-mediated neurodegeneration independently of amyloid-β pathology.
Our results demonstrate that autophagic activity decreases with aging , and may be responsible for the cytoprotective effects in young cartilage.
Our results demonstrate that both the amount and the trafficking profile of B cells are related to the severity of AD.
Our results demonstrate that , contrary to popular public belief , older minds depict socially relevant information more accurately than their younger counterparts.
Our results demonstrate that gene expression changes associated with psychiatric disease and aging result from epigenetic mechanisms involving histone acetylation.
Our results demonstrate that hypoxia activates Notch signaling and up-regulates TRPC6 channels.
Our results demonstrate that inhibiting glycolysis by targeting lactic acid export sensitizes NSCLC to phenformin.
Our results demonstrate that in the majority of adults there is a naturally acquired humoral and cellular immune response to the three pneumococcal proteins tested.
Our results demonstrate that maintenance of quiescence in adult life depends on the active repression of senescence pathways.
Our results demonstrate that @percent@ of respondents consider themselves as potential social oocyte freezers , of which @percent@ would definitely consider the procedure.
Our results demonstrate that plasminogen functions in stimulating conversion processes and represents the first cellular protein cofactor that enhances the hypothetical mechanism of prion propagation.
Our results demonstrate that the age-related changes in gene expression are manifested earlier in AD.
Our results demonstrate that the BM houses decreased numbers of plasma cells in old age.
Our results demonstrate that the cardiovascular disease-induced reduction in cardiac output and skin blood flow causes extra elevation in core temperature during hyperthermic challenges.
Our results demonstrate that there are strong reciprocal associations between these two factors.
Our results demonstrate that this physical activity counseling intervention had a positive impact on self-selected goals over the course of the intervention.
Our results demonstrate that verbascoside increased the phosphorylation of SHP-1 , by attenuating the activation of TAK-1 / JNK / AP-1 signalling.
Our results demonstrate that Wip1 may protect the BBB against LPS-induced integrity disruption and inflammatory response through the SHH signaling pathway.
Our results demonstrate the potential of Sal-T as a convenient measure of tissue androgen exposure for population research.
Our results demonstrate the relevance of poly ( ADP-ribose ) metabolism for aging and development in P. anserina.
Our results did not show any differences in the frequency of XRCC1 gene polymorphisms between ALS patients and controls free of any neurological disease.
Our results did not show a universal association between the mitochondrial C150T polymorphism and longevity in this population.
Our results documented that internal consistency reliability was high for the subjective childhood neighborhood scales ( Cronbach's α = 0.89 , @number@ ) .
Our results do not argue in favor of antibiotics as the mainstay of therapy in late granulomas related to permanent fillers.
Our results do not confirm the contribution of OPTN in ALS.
Our results do not support a role for RIC3 mutations as a common cause of PD in the French-Canadian and French populations.
Our results do not support the hypothesis that household savings increase with the health risks that they face.
Our results echoed the limited findings reported in the literature.
Our results emphasize that the age of the actual end-user should be taken into account when designing neurorehabilitation protocols.
Our results emphasize the need for physicians to closely monitor GI bleeding in aging patients , because it is closely related to renal function deterioration.
Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance.
Our results , for the first time , implicate sirtuins as a central player in the determination of platelet aging.
Our results for the first time show a significant , age-independent association between the levels of IGF1 and AGEs.
Our results found that the mobility hierarchical disability categorization model is a valid and time efficient tool for large survey or screening use.
Our results further demonstrate sizable associations in levels and changes in functional limitations and depressive symptoms between spouses.
Our results furthermore emphasize the important role of the Notch pathway in pigmentation and keratinocyte morphology.
Our results further revealed that repression of Shc expression by let-7a delays senescence of human diploid fibroblasts ( HDFs ) .
Our results further showed that ELF-EMF exposure induced the activity and expressions of MMP-9.
Our results give an overview of the characteristics of the d-galactose rodent ageing model , including neurobehavioral and neurochemical outcomes.
Our results highlight a novel role for miR-377-DNMT1-p53 axis in HSF senescence.
Our results highlight that optimization of exercise and amino acid-based nutrition is sufficient to induce a comparable MPS response between young and older individuals.
Our results highlight the central role of the posterior cingulate cortex in a slow but reliable memory decline in elderly.
Our results highlight the high prevalence ( @percent@ ) of one or more geriatric conditions and their independent association with excess hospital utilizations.
Our results highlight the impact of miR-125b function via methylation by NSun2.
Our results highlight the importance of age and gender-based analyses and the potential of LV diffusivity measures as a quantitative marker.
Our results highlight the importance of developing appropriate policies and programs to support caregivers.
Our results highlight the importance of encouraging white collar workers to engage in physical activity during or outside work hours.
Our results highlight the importance of the interactions of age , strain and METH dose on locomotor behavioral outcomes.
Our results highlight the importance of using grandchild production to understand selection on human life-history traits.
Our results highlight the need to educate health care clinicians on the care of patients with developmental disabilities of all ages.
Our results highlight training-induced balance improvements in PD patients that may be associated with specific patterns of structural brain plasticity.
Our results identify a novel pathogenic PS1 F388L mutation in a Chinese FAD family.
Our results identify CDC25C as a downstream target of the mutated tyrosine kinase FLT3-ITD affecting cell-cycle regulation in a model of AML.
Our results identify deficits in critical regulatory pathways in the antiviral response that may contribute to the enhanced susceptibility to viral infections observed in aging.
Our results identify intradermal EP vaccination as a promising method for delivering Her2 / neu DNA vaccine.
Our results implicate adolescence as a developmental phase of increased neural risk sensitivity.
Our results implied that family background importantly affects tooth loss in both the middle-aged and the older populations.
Our results imply that CSF α-synuclein is currently unsuitable as biomarker to differentiate between PD and AP.
Our results indicate a fundamental link between the thoughts and stress levels we experience.
Our results indicate a significant increase in Hsp70 serum levels with increasing degree of inflammation.
Our results indicate both constitutive and differential phosphorylation of sMyBP-C in aged and diseased muscles.
Our results indicated OPRK1 was significantly hypermethylated in Xinjiang Han MCI females.
Our results indicated that ATO may exert an anti-tumor effect by influencing bone marrow micro-environment.
Our results indicated that B. animalis @number@ has the potential to be developed into a dietary antioxidant supplements.
Our results indicated that gender and age have only minor effects on the immune modulation of probiotics.
Our results indicated that IHD mortality in China increased significantly over the three decades studied.
Our results indicated that K2 is acetylated at an early age and that the amount of K2-acetylated γD-crystallin increased with age.
Our results indicated that regional cerebellar volumes show different patterns with respect to age.
Our results indicated that the DPP was feasible and that health care staff would accept it under certain conditions.
Our results indicated that the RTECs in IgAN patients exhibited features of accelerated senescence , which were unrelated to mechanisms associated with normal aging.
Our results indicated that this is possible.
Our results indicate increased connectivity between the left and right PT in musicians compared to nonmusicians , as indexed by reduced mean RD.
Our results indicate marked involvement of glutamatergic striatal inputs from the cerebral cortices in association with socio-cognitive declines in a disease spectrum of TDP-43 proteinopathy.
Our results indicate stage- and region-dependent deregulation of purine metabolism in AD.
Our results indicate that age-induced differences on bone strength entail significant alterations not only of bone mass , but also of bone geometry.
Our results indicate that aging differentially affects distinct forms of suppression arising at various levels of the visual pathway.
Our results indicate that a good outcome can be expected from conservative treatment in elderly patients as well as the young.
Our results indicate that attention is selectively and independently influenced by age and task demands , with both effects dependent on how attention is measured.
Our results indicate that , besides BM-MSCs , UCB-MSCs might be a potent and reliable candidate for future therapeutic applications.
Our results indicate that BMP antagonists will be good targets for skin or hair diseases.
Our results indicate that computational anatomy can detect AD substantially earlier than suggested by current models.
Our results indicate that consumption of a PRO beverage after aerobic exercise increased WBPT to a greater extent than a CHO beverage.
Our results indicate that existing normalization techniques do not provide satisfactory overlap to analyze the functional specialization within the DCN.
Our results indicate that fully Bayesian inference can successfully be applied for preprocessing and statistical analysis of structural MRI data.
Our results indicate that functional measures , inflammatory markers , and endothelin-1 are predictors of 360-day survival in centenarians.
Our results indicate that genetic vulnerability to Alzheimer's disease may alter whole-brain functional networks even before clinical symptoms appear.
Our results indicate that GH and IGF are potent regulators of humanin levels and that humanin levels correlate with lifespan in mice.
Our results indicate that increased lens filtering does not necessarily lead to a decreased non-visual sensitivity to light.
Our results indicate that large males had greater mating capacity than small males.
Our results indicate that LC-MRI contrast corresponds to the location of neuromelanin cells in LC ; these also correspond to norepinephrine neurons.
Our results indicate that microsaccades are more prevalently oblique in patients with Alzheimer's disease or mild cognitive impairment than in healthy subjects.
Our results indicate that neural resources devoted to postural control are reduced under dual-task conditions that engage attention.
Our results indicate that neuronal mitochondria are responsive to oxygen levels and produce differential responses under different oxygen levels.
Our results indicate that novel anti-inflammatory drugs may resolve imbalanced inflammation and improve outcomes in older people infected with viruses.
Our results indicate that older adults exhibit impaired endpoint accuracy with both limbs due to greater time variability.
Our results indicate that older adults' ; performance on cognitive tests reflects the predictable consequences of learning on information-processing , and not cognitive decline.
Our results indicate that OMS decrease the patient's pain , modify CoP mean position and decreased the length and velocity of the CoP displacement.
Our results indicate that PARP-1 plays a central role in mitochondrial homeostasis by epigenetically regulating nuclear genes involved in mtDNA repair and transcription.
Our results indicate that PDCs from the aged are impaired in their capacity to secrete IFN-I in response to influenza virus and CPG stimulation.
Our results indicate that plasma Q10 levels in old people are higher that the levels found in young people.
Our results indicate that rule switching differentially impacts two key processes underlying cognitive control in children and adults.
Our results indicate that Ser-31 phosphorylation may regulate TH subcellular localization by enabling its transport along microtubules , notably toward the projection terminals.
Our results indicate that statin are potential therapeutic agents for protection of articular cartilage against the progression of OA.
Our results indicate that the aged human cortex is under steady pressure from specific and potentially detrimental membrane protein oxidation.
Our results indicate that the connectome disintegration pattern of MCI subgroups differ with respect to brain amyloid and neurodegeneration.
Our results indicate that the duration of overweight is an important aggravating factor for arterial stiffness , especially during middle age.
Our results indicate that the excretion of dabigatran may be affected by aging , as compared to warfarin , likely due to renal function decline.
Our results indicate that the Mifflin-St Jeor equation ( using FFM ) is the most accurate equation estimating REE in these octogenarian men.
Our results indicate that using cohort instead of period life expectancy returns around @number@ extra younger people per older person among the analysed countries.
Our results link age-related declines in the efficiency of frontal cortex functioning with lower WM integrity in aging.
Our results may also indicate an off-label prescribing of AEDs as an alternative to psychotropics in the institutional setting.
Our results may indicate that in these patients , improvements in disability are not necessarily dependent on improvements in strength and power or ROM.
Our results may provide a reference for health care providers in countries using similar programs with Chinese / Taiwanese immigrant populations.
Our results may reflect the differential contributions of Kid and CENP-E in chromosome congression in physiological conditions where stabilized microtubules are becoming increased.
Our results may support the hypothesis that ATXN2 polyQ expansion is a specific predisposing factor for multiple neurodegenerative diseases.
Our results need to be confirmed in other populations and countries.
Our results offer new insights into the mechanisms subsuming complex emotions and moral cognition in neurodegeneration.
Our results point to a new , unique approach enabling the elimination non-cycling uterine leiomyosarcoma cells providing that they over-express the AT₂ receptor.
Our results point to a possible beneficial effect of isoflavone on some abilities of the central executive.
Our results point to DBC1 as a novel regulator of gluconeogenesis.
Our results point to the benefits of prolonged exercise from adulthood to old age.
Our results present the heritability of brain volume in middle to advanced age as possibly higher in East Asian adults.
Our results provide a basis for further development of ART as a novel therapeutic agent for the treatment of breast cancer.
Our results provide a mechanistic basis for the age-associated regulation of the HSR.
Our results provide a mechanistic rationale for how RMI1 stabilizes TopIIIα-gate opening to enable dissolution and illustrate how binding partners modulate topoisomerase function.
Our results provide a possibility that miRNAs detected in plasma and CSF can serve as biomarkers for AD.
Our results provide a potential explanation for the inconsistent associations between smoking and TL reported in previous cross-sectional studies.
Our results provide a proof of principle for the rescue of intrinsic B-cell defects and the humoral immune response in senescence.
Our results provide a unique extension of COR theory.
Our results provided the clues as to the link between these diseases using pathway analysis methods.
Our results provide evidence that the natural history of alternating hemiplegia is highly variable and unpredictable for individual patients.
Our results provide further mechanistic insight into MiDAS and define a specific function for human RAD52.
Our results provide important novel insight into the potential disease mechanisms underlying the neurodegenerative consequences of CISD2 mutations and the subsequent development of multisystemic disease.
Our results provide input to target policies towards elderly individuals in need of lifestyle change.
Our results provide insight into AChE-amyloid interrelationships.
Our results provide insight into functional genomic networks involving non-coding regulatory elements that are involved in healthy aging and longevity.
Our results provide insight into the effects of regulatory variants and their relationship to population history and individual genetic risk.
Our results provide insights into the neural systems underlying the relationship between CV risk and executive function.
Our results provide new clues for genetic mechanisms of longevity and shed light on strategies for evaluating rare mitochondrial variants that underlie complex traits.
Our results provide new evidence that the LC , in interaction with the parahippocampal gyrus , may contribute to episodic memory formation.
Our results provide new insights into how mitochondrial RC dysfunction mechanistically interferes with the apoptotic machinery.
Our results provide novel insights into platelet physiology as well as growth , development and ageing in healthy individuals.
Our results provide practical evidence with which to formulate new safety policies , including mandatory seatbelt use , driving age limits and insurance pricing.
Our results provide strong , longitudinal evidence of cognitive aging in midlife women , with substantial within-woman declines in processing speed and memory.
Our results provide strong support for extensive pleiotropy across this region of 5p15.33 , to an extent not previously observed in other cancer susceptibility loci.
Our results provide timely and relevant information for miRNAs as potential diagnostic biomarkers for CRC.
Our results reinforce RTL as a marker for PAD that reflects the influence of genetic and environmental risk factors.
Our results , reinforce the hypothesis of a physiological correlation between HERVs activity and the different stages of life in humans.
Our results replicate both the correlation between the two methods and their reliability as previously reported by studies using human subjects.
Our results replicate several previous age- and sex-related findings and show how some previously observed changes during childhood extend throughout the lifespan.
Our results reveal a novel mechanism by which LRP1 controls synaptic integrity and function , specifically by regulating GluA1 trafficking , phosphorylation and turnover.
Our results reveal a p53-dependent cell-survival pathway and highlight the importance of the CL content of mitochondrial membranes in apoptosis.
Our results revealed an impairment in the neurovascular coupling along aging in the 3xTg-AD mice which preceded obvious cognitive decline.
Our results revealed associations between higher VCDT and lower MD in the bilateral globus pallidus.
Our results revealed atypicalities in both the FFA and EBA in children with ASD but not in adults with ASD.
Our results revealed complex interactions among the effects of the three basic life history stages and the benefit to defect.
Our results revealed reliable group effects in nontrained standard clinical measures of WM and visuospatial skills in that both training groups outperformed the control group.
Our results revealed statistically significant relationships between several physiologic variables and measures of stress.
Our results revealed that 17β-estradiol treatment before and after ethanol decrease expression of occludin and claudin-1 and value of TEER which are BBB disrupt indicators.
Our results revealed that increased allostatic load was associated with increased depressive symptoms on the same year of assessment.
Our results revealed that Sikkim is a biocultural hotspot , where six ethnic communities and @number@ species engage in biocultural relationships.
Our results reveal NKAP as nuclear speckle protein with roles in RNA splicing and processing.
Our results reveal potential molecular targets for intervention in synaptic failure and prevention of cognitive decline in VaD.
Our results reveal that SMN upregulation slows locomotor deficit onset and motor neuron loss in this mouse model of ALS.
Our results reveal that the microglial population is constantly and rapidly remodeled , expanding our understanding of its role in the maintenance of brain homeostasis.
Our results seemed robust to a number of sensitivity tests.
Our results shed light on the variability in psychological adaptation and underline the important role of intrapersonal resources in facing spousal loss in old age.
Our results should stimulate review of current policy and resource allocation.
Our results show an impact of genotype already in middle-age with significantly better performance in AT-carriers.
Our results show a pronounced down-regulation of several components of the mitochondrial ATPase complex accompanied by up-regulation of some glycolytic enzymes.
Our results show a trend of immobilization in older persons affecting the vasoconstrictory endothelial response.
Our results show direct evidence of reductive DNA damage in the cells.
Our results showed a significant overall sleep-based beneficial effect in young adults but not in older adults.
Our results showed decreasing CFTR and increasing COX2 expression in rat prostate tissues with aging.
Our results showed high echogenicity of the polymeric valve , that was correlated to the severity of the calcification.
Our results showed increased dual-task interference on step initiation times and variability in female PM compared with control subjects.
Our results showed that 25-OH exhibited an increasing after UV irradiation , highlighting the pivotal role of this oxysterol in skin degeneration.
Our results showed that APC inhibited MGO-induced cardiomyocyte apoptosis and ER stress-related gene expression.
Our results showed that beta-galactosidase activity can be considered as a replicative senescence marker of the ovarian surface epithelium at pH @number@
Our results showed that biodynes , TRF , and tocopherol upregulated collagen genes and downregulated MMP genes ( P < @number@ ) .
Our results showed that compound @number@ did not alter fMLF-induced phosphorylation of Src ( Src family Y416 ) .
Our results showed that CSE-treated mice had thinner epidermal layers and denser dermal collagen fibers than untreated mice.
Our results showed that CSIG promoted the proliferation of HepG2 and SMMC7721 cells in vivo.
Our results showed that , during in vitro long-term ( 5-day ) cell sheet culture , MSCs progressively lose their progenitor characteristics.
Our results showed that endogenous HIF1A knockdown increased AIEC survival in intestinal epithelial cells.
Our results showed that inhibition of cell viability , induction of apoptosis and DNA damage by treatment with fucoidan were similar in two cell lines.
Our results showed that in vitro fertilization treatments have a weak risk at the genetic level in cultured human lymphocytes.
Our results showed that mainly the pure prospective memory processes within prospective memory lead to lower prospective memory performance in young children and old adults.
Our results showed that MHY336 treatment increased the expression of p53 over time in cells with wild-type p53 status.
Our results showed that mutations in PSEN1 gene might be common in Chinese EOFAD families.
Our results showed that MV counts increase over time and , thus , could serve as an effective metric of blood aging.
Our results showed that not all the EPS increased MCF-7 proliferation.
Our results showed that @percent@ of subjects were diagnosed with PD during life but that @percent@ had bLBD at autopsy.
Our results showed that rice berry could significantly prevent memory impairment and hippocampal neurodegeneration in hippocampus.
Our results showed that the association of antihypertensive response to irbesartan and the KCNJ11 genetic variant in the total sample was not significant.
Our results showed that the beneficial effect of sleep on memory consolidation was reduced in older adults compared to young adults.
Our results showed that the formulation MAF14001 can protect SK-N-SH cells against Aβ-induced toxicity.
Our results showed that vitamin D insufficiency is highly prevalent in the population of healthy women.
Our results show no significant differences in tear film stability with age.
Our results show not only on-task training improvements but also robust generalization of benefit to other cognitive control abilities.
Our results show promise in an area of great importance to ensure optimum outcomes for medications used in older adults.
Our results show that age discrimination is an antecedent for the desired retirement age.
Our results show that an integrated in vivo-in silico approach could improve both mathematical and biological models of cancer immunoprevention.
Our results show that both measures of health changes are predictive of mortality in the model controlling for levels of SAH and socioeconomic characteristics only.
Our results show that CDC42 constitutive activation does not interfere with HeLa cell migration after UV radiation.
Our results show that collagen XVII expression is mainly confined to an ultrastructurally definable , specific type of lipofuscin granule.
Our results show that cordycepin resulted in significant reduction in LNCaP cell survival by inducing apoptotic cell death.
Our results show that disassembly of polyubiquitin chains by USP5 at sites of damage is important for efficient DSB repair.
Our results show that EMS exerts its anti-inflammatory effect by inhibiting NF-κB-regulated genes such as IL-1β and IL-8.
Our results show that familiarity with the arboreal-like course allowed the athletes to substantially reduce their energy expenditure.
Our results show that fibroblasts recapitulate some of hallmark TDP-43 abnormalities observed in neuronal cells.
Our results show that it is feasible to use technology-based assessment protocols with older adults and patients with schizophrenia.
Our results show that it is possible to accurately estimate ocular media density in vivo in humans.
Our results show that miR-182- and miR-183-regulated pathways are necessary for cone outer segment maintenance in vivo and functional outer segment formation in vitro.
Our results show that NANOG could reverse the effects of stem cell senescence and restore the myogenic differentiation potential of senescent MSCs.
Our results show that only post-movement β amplitude and not δ-θ phase locking is involved in the control of movement accuracy.
Our results show that pre-treatment with ASTA ( @number@ µM ) for @number@ h attenuates the LPS-induced toxicity and ROS production.
Our results show that rare GCH1 variants are associated with an increased risk for Parkinson's disease.
Our results show that the age-specific variance components of these two traits exhibited substantially different patterns despite of comparable estimates of heritability.
Our results show that the fatty acids in vegetable oil incorporate into retinal cells and increase the plasma membrane fluidity.
Our results show that the reduced viability of @number@ cells by sulforaphane is due to mitotic arrest , but not the G2 phase.
Our results show that theta inter-trial coherence during NoGo trials increases from childhood to early adulthood , and decreases from early adulthood to old age.
Our results show that verbalizing during learning slows down reaction times ( RTs ) but does not influence the amount of implicit learning.
Our results show the promise of combination therapy of PEG-PEI-Ce6 nanoparticles for delivery of Wnt-1 siRNA along with PDT in the treatment of oral cancer.
Our results show VZV , like other human herpesviruses , encodes several sncRNAs and miRNAs , and some may regulate infection of host cells.
Our results strengthen the hypothesis that the longevity of parents may influence the health status of their offspring.
Our results strongly suggest that stem cells of the heart are not involved in the regeneration of human myocardium during aging.
Our results suggest a function of pol ν in meiotic homologous recombination in processing specific substrates.
Our results suggest a molecular mechanism that involves signaling pathways mediated by PI-3k / Akt and Erk.
Our results suggest an age-related significant influence of time-varying coupling of spatially patterned EEG rhythms on motor cortex excitability in response to TMS.
Our results suggest an association between skin aging and 25 ( OH ) D levels.
Our results suggest a new and feasible strategy for protection against cardiovascular disease.
Our results suggest an impairment of WM networks in preclinical AD that is detectable while other structural imaging markers do not yet indicate incipient neurodegeneration.
Our results suggest an important role of the PI3K-Akt pathway in the senescence and self-renewal of hSKPs.
Our results suggest a positive association of dairy intake with appendicular bone mineralization and muscle mass in elderly women.
Our results suggest a putative correlation between the the rs144989913 SNP and aging , both successful and unsuccessful , rather than age-related diseases.
Our results suggest a role for inflammation in brain atrophy and cognitive changes in cognitively normal older adults , which partly depended on Aβ accumulation.
Our results suggest a starting point for the prevention of oxidative processes associated with aging.
Our results suggest caution in interpreting the tables in heterogeneous clinical populations , as the MMSE-MoCA relationship may be different across dementia subtypes.
Our results suggest difficulties in attentional control and executive functions.
Our results suggested important modifications in cytosolic , mitochondrial and lipid energy metabolism , which may relate to dysfunctions in old muscle force generation.
Our results suggested potential interactions between zinc status , epigenetics , and immune function , and how their dysregulation could contribute to chronic inflammation.
Our results suggest that 17β-estradiol may act in an age-dependent manner in the postischemic rat brain.
Our results suggest that acute myocardial infarction and reperfusion accelerate immunosenescence in patients.
Our results suggest that ADSC therapy may be useful in ageing skin.
Our results suggest that age is a risk factor for developing PTS symptoms under prolonged exposure to rocket attacks.
Our results suggest that age related accumulation of NM might induce α-synuclein over-expression and thereby make dopamine neurons more vulnerable to injuries.
Our results suggest that age-related changes need to be considered in studies evaluating inter-segmental motion of the foot.
Our results suggest that age-related cognitive decline exacerbates older adults ' deficits in detecting anger , but only from static faces.
Our results suggest that age related muscle atrophy affect both human skeletal muscles.
Our results suggest that age-related reductions in efficiency and successful compensation can co-exist in older adults in the context of the same task.
Our results suggest that aging along with both heart and lung irradiation plays a fundamental role in the risk of developing RILF.
Our results suggest that alcohol consumption is a similar risk factor for incident hypertension in both the middle-aged and the older populations.
Our results suggest that allostatic load measure is associated with late-life depressive symptoms.
Our results suggest that AMD and AD share genetic mechanisms.
Our results suggest that a minority of AD related SNPs may be associated with non-clinical cognitive decline.
Our results suggest that antibodies to C4S could be a useful therapeutic to restore memory function in neurodegenerative disorders.
Our results suggest that an ultrasound equation for TMM is appropriate and useful for evaluating skeletal muscle mass in the body.
Our results suggest that appendicular as well as site-specific thigh muscle loss with aging were not observed in masters cyclists.
Our results suggest that APT is often inappropriately prescribed instead of OAC.
Our results suggest that a small fraction of the gender-associated RBPs ( ~40% ) are expressed higher in males than females.
Our results suggest that assessing long-term chronic inflammation by repeat measurement of interleukin-6 has the potential to guide clinical practice.
Our results suggest that autophagic activity in odontoblasts is a fundamental mechanism to ensure turnover and degradation of subcellular components.
Our results suggest that baseline regional gray matter volume predicts the rate of global gray matter volume decline in the subsequent period in healthy subjects.
Our results suggest that besides APOE , other genes associated with AD risk do not exert large effects on the AAO phenotype of AD.
Our results suggest that betaine inhibits the FOXO1 binding to TXNIP , leading to the suppression of RS-induced NLRP3 inflammasome activation in a diabetic liver.
Our results suggest that both biological aging and reduced regenerative capacity contribute to cardiovascular events , independent of conventional risk factors.
Our results suggest that cardiorespiratory capacity and economy of movement are associated with muscular strength during aging.
Our results suggest that cerebellum-vmPFC coupling may be related to cognitive function whereas cerebellum-PCC coupling may be related to emotion processing in geriatric depression.
Our results suggest that CGI methylation in normal colorectal mucosa is related to advancing age , race , rectal location , and RBC folate levels.
Our results suggest that C-HC induces non-cell-autonomous senescence and accelerates biological aging.
Our results suggest that childhood stress might lead to accelerated telomere shortening seen at the adult age.
Our results suggest that clinically silent AD pathology is related to lower expression of a fronto-visual fC pattern supporting executive task performance.
Our results suggest that complete neuroautonomic evaluation should be done particularly in older patients.
Our results suggest that cordycepin may possess chondroprotective effect by preventing cartilage denegation and interfering inflammatory response in the pathogenesis of OA.
Our results suggest that dietary magnesium may aid conservation of age-related loss of skeletal muscle mass and power in women of all ages.
Our results suggest that down-regulation of PPP enzymes and a failure to increase antioxidant reserve is an early event in the pathogenesis of sporadic PD.
Our results suggest that endothelial dysfunction , associated with high levels of OxS , could be entailed in an increment of telomere attrition.
Our results suggest that engaging in higher intensity PA may have protective effects on neural processing in aging.
Our results suggest that enzalutamide may have the potential to treat patients with advanced gemcitabine-resistant bladder cancer with increased AR expression.
Our results suggest that expectation-based detection ability varies with age and , for older adults , also with axis of motion.
Our results suggest that familial exceptional longevity may be achieved through heterogeneous yet correlated pathways.
Our results suggest that fat ( DXA ) represents different parts of AT depots in elderly men and women.
Our results suggest that forearm-ulna MT may be a useful parameter for evaluating handgrip strength and TMM index in older Japanese men and women.
Our results suggest that for much of the life course , coresidence serves to benefit primarily the adult children rather than their older mother.
Our results suggest that genetic factors in males have a higher impact than in females on attaining longevity.
Our results suggest that genetic regulation of SORL1 expression plays a role in disease risk and may be responsible for the reported LOAD associations.
Our results suggest that genetic variations of MC1R are important determinants for severe photoaging.
Our results suggest that higher plasma GM3 levels are associated with PD.
Our results suggest that high SHBG may also be a risk factor for hyperkyphosis. © @number@ American Society for Bone and Mineral Research.
Our results suggest that hyperleucinemia may account , in part , for the association of insulin resistance / T2D with AD.
Our results suggest that hypnotic suggestions might be a successful alternative for widely-used sleep-enhancing medication to extend SWS and improve cognition in the elderly.
Our results suggest that increasing Akt / NF-κB is a crucial mediator of skin aging , which can increase the susceptibility of cell transformation.
Our results suggest that in Germans , none of the three genes plays a significant role in the ability to reach old age.
Our results suggest that lifelong bilingualism contributes to CR against WM integrity declines in aging.
Our results suggest that lower SPI1 expression reduces AD risk by regulating myeloid gene expression and cell function.
Our results suggest that low serum paraoxonase activity is a risk factor for AD.
Our results suggest that lung function is a good ' summary ' measure of overall functioning in early old age.
Our results suggest that LUTS is associated with aging , regardless of the presence of the metabolic syndrome.
Our results suggest that medication use is unlikely to contribute to clinically relevant changes in plasma homocysteine levels.
Our results suggest that microRNAs involved in synaptic plasticity might be an important factor that contributes to AD neuropathology.
Our results suggest that miR-141-based therapies could be developed to treat pathologies where BMI1 is deregulated.
Our results suggest that missense mutations in DNAJC13 , DNAJC5 and DNAJC6 do not play a major role in PD in the Chinese population.
Our results suggest that mitochondrial dysfunction contributes to premature organ decline and aging in HGPS.
Our results suggest that MoCA can be a useful tool to detect cognitive decline.
Our results suggest that N11 has the potential to be developed to treat neutrophil-mediated inflammatory diseases.
Our results suggest that OAB is associated with aging regardless of the presence of metabolic syndrome.
Our results suggest that OGT and OGA gene expressions are associated with muscle size during the critical postmenopausal period.
Our results suggest that orally ingested dietary vitamin D3 in aged mice improves glucose metabolism as a GLP-1 enhancer.
Our results suggest that population-based studies likely underestimate the prevalence of dementia and mild cognitive impairment , especially if the participation rate is low.
Our results suggest that protein intakes > 1.0 g / ( kg · d ) are protective against weight loss in healthy older adults.
Our results suggest that PWMH are associated with frontal thinning , which is further associated with frontal executive dysfunction.
Our results suggest that racial differences in cellular aging in the placenta contribute to the earliest roots of health disparities.
Our results suggest that sarcopenia is common among osteoporotic women increasing along with the number of vertebral fragility fractures.
Our results suggest that SHEDs and SH-CM should be constitutionally suited for photoaging treatment.
Our results suggest that social engagement and satisfying relationships confer benefits for affective well-being that are retained into late life.
Our results suggest that the age-related decline in the rapid vasodilator response to local heating in human skin is explained by diminished sensory nerve-mediated vasodilatation.
Our results suggest that the ATSC-Ex have improving effect of wound healing and can be the potential therapeutic candidate for cutaneous wound healing.
Our results suggest that the FOK accuracy deficit observed in the literature arises from differences in memory performance.
Our results suggest that the impact of brain pathology on the risk of dementia is modified by premorbid brain size.
Our results suggest that the impairment of joint motion is a result of age-related osteoarticular degenerative changes.
Our results suggest that the implicit detection of visual social signals involves the pMTG and underlies the development of higher social cognition.
Our results suggest that the involvement of the FBXO7 gene in PD is very rare , at least in this population from southern Spain.
Our results suggest that the positivity effect in memory is not entirely due to the sense of familiarity for smiling faces.
Our results suggest that the prevalence and severity of conjunctivochalasis are related to the presence of pinguecula.
Our results suggest that there are three decisive stages in volunteering : recruitment , realization of volunteer activity , and pursuit of this commitment.
Our results suggest that there is no considerable influence of sequence variation in the SOD genes on human longevity in Germans.
Our results suggest that the relationship between short telomeres and mortality is tied to inflammation and homocysteine.
Our results suggest that the retinal section between the internal and external limiting membrane is involved in the spatial distribution of MPOD.
Our results suggest that these components should be evaluated in various settings outside the healthcare sector.
Our results suggest that the use of anticholinergic drugs is associated with functional impairment , especially in old age subjects with initial cognitive impairment.
Our results suggest that the use of high-dose B-vitamin supplements was associated with an increased risk for cataract.
Our results suggest that the use of nucleases during cell lysis severely restricts interacting protein partners and thus enhances specificity.
Our results suggest that the use of some personal care products contributes to phthalate body burden that deserves attention due to its potential health impact.
Our results suggest that thigh MTH ratio is independent of age-related muscle mass loss detected by aLM.
Our results suggest that this relation is particularly positive if the network is comprised of family members.
Our results suggest that to improve reaction time values , it is advisable to include cognitive features into a physical exercise routine.
Our results suggest that visual tracking abilities decline with age and that postural challenge affects accuracy but not timing of gaze responses.
Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process.
Our results suggest the presence of functional NR1 / NR3 receptors in CNS myelin.
Our results suggest the significant association between certain aspects of social capital , at both the individual and the community level , and self-rated health.
Our results support a role of variants in inflammatory pathway genes in CRC susceptibility and progression.
Our results supported both hypotheses.
Our results support previous findings on the efficacy of these actives.
Our results support previously reported associations between the L / M ratio and factors related to child nutritional status and enteropathogen exposure.
Our results support the administration of intravenous rtPA in selected elderly stroke patients presenting early to the hospital in developing countries.
Our results support the feasibility of , interest in , and desirability of implementation.
Our results support the hypothesis that failure of proteasomal and non-proteasomal proteolytic clearance mechanisms leads to tau accumulation and progressive neurofibrillary degeneration in AD.
Our results support the idea that apigenin is a promising natural product for reducing the impact of senescent cells on age-related diseases such as cancer.
Our results support the notion that individual differences in WM performance are important to consider when studying the WM network , particularly in age-comparative studies.
Our results support the potential contribution of age-related changes in CRF effects to aging anorexia and cachexia.
Our results support the potential of cell-based and systemic therapies for progeria and highlight ZMPSTE24 as a new anticancer target.
Our results support the potential of C. sativum L. to prevent skin photoaging.
Our results support the presence of LOAD variants and heterogeneity at the GAPDH locus.
Our results support the recommendation to offer HCV antiviral therapy to HIV / HCV-coinfected patients at early stages of liver fibrosis.
Our results thereby establish mammalian MTO1 as a novel factor in the tissue-specific regulation of OXPHOS and fine tuning of mitochondrial translation accuracy.
Our results thus implicate STX1B and the presynaptic release machinery in fever-associated epilepsy syndromes.
Our results thus provide detailed insight into the methylation dynamics during differentiation and suggest that epigenetic changes contribute to hematopoietic progenitor cell aging.
Our results thus suggest the link between age-related epigenetic changes and impaired T cell function.
Our result suggested that HA and γ-globulin may play a significant role in improving frictional behavior of advanced OA cartilage.
Our results underline the interest of repeated BMI and motor assessments to identify those at higher risk of disability.
Our results underscore the importance of nursing homes ' processes in facilitating discussions of nursing home residents ' end-of-life care preferences.
Our results underscore the role of the investigated miRNAs in colorectal cancer and their potential utility as prognostic biomarkers.
Our results validate QTIP to study telomeric states during normal development and in disease.
Our results warrant further study to clarify the pathophysiological state of the CN or FN using 3D-CISS.
Our review also highlights the urgent need for investigations on preventive interventions in individuals at risk for mental disorders.
Our review encompassed @number@ guidelines , @number@ original studies , and @number@ review articles published from @number@ to the present.
Our review found a positive effect on bone health for supplements ; food-based interventions ; and educational strategies.
Our review highlights the lack of common intent in terms of study design and the presence of different primary and secondary outcomes.
Our review of high-quality retrospective studies was able to elucidate the clinical risks of age on the outcomes after liver surgery in specific patient populations.
Our review shows that older adults are able to perform a postural dual task as well as younger adults in stable conditions.
Our review summarizes the critical roles of miRNAs in stem cell reprogramming , pluripotency maintenance , and differentiation.
Our review summarizes the latest new findings of FTLD and challenges in FTLD therapy.
Our review therefore considers the role of the FTO gene in the early-life determination of body weight , body composition and energy balance.
Our review will summarize the recent developments related to acetylation-dependent responses following metabolic stress in skeletal muscle.
Our RUNX1 ChIP-seq analysis indicated that RUNX1 is recruited to AR binding sites by interacting with AR.
Our sample comprised @number@ community-dwellers aged ≥50 years in @date@ from the English Longitudinal Study of Ageing.
Our sample consisted of @number@ community-dwelling African Americans aged @number@ and older , participating in the 2010-2012 rounds of the Health and Retirement Study.
Our sample consisted of @number@ men and women 68-77 years of age , mostly White , and predominantly middle class.
Our sample consists of @number@ people aged 40-80 at baseline who were surveyed in 2002-2003 ( T1 ) and 2007-2008 ( T2 ) .
Our sample contained @number@ poor and @number@ non-poor individuals.
Our sample included @number@ adults who were assessed up to six times across an average of @number@ years.
Our sample included @number@ Filipino formal caregivers to older persons ( age 65 + ) suffering from cancer or other chronic diseases.
Our sample included @number@ high-Aβ older adults , @number@ demographically matched low-Aβ older adults , and @number@ young adults.
Our sample included @number@ high-functioning adults who participated in the Health , Aging and Body Composition Study ( age range : 70-79 years ) .
Our screening , using a reverse-phase protein array , revealed distinct mechanisms by which PAKs mediate resistance to BRAFi and the combined therapy.
Our search revealed that physicians ' dependence on hospital management has increased along with healthcare reforms and the resulting emphasis on business logics.
Our search was restricted to studies involving humans aged @number@ years or older , and written in English , Spanish , or Portuguese.
Our second aim was to improve the CAIDE risk score by additional midlife risk factors.
Our secondary aim was to identify potential factors that improved outcome.
Our secondary objective was to explore the associations between the components of the HEI-2005 and the MyPyramid food groups and BTMs.
Our secondary objective was to investigate the beneficial effect of cognitive reserve on these interrelationships.
Our second deferred imitation study required the children to reproduce actions on an object in a room , thereby affording layout-based spatial cues.
Our second objective was to test the programme in small groups of older adults.
Our selection criteria included : ( @number@ ) activities of daily living , ( @number@ ) ICT , and ( @number@ ) dementia.
Our series consisted of @number@ hospitalized patients with a mean ± SD age of @number@ ± @number@ years enrolled in the GIFA study.
Our series consisted of @number@ participants aged @number@ and older.
Our series of cases helps analyse the efficiency and safety of L-polylactic acid in the management of facial ageing.
Our short report confirmed the effects of SNPs near TERC on LTL in the Chinese Han population for the first time.
Our signature distinguished these two groups , with an area under the receiver operating characteristic curve of @percent@ ( P < @number@ ) .
Our simulations suggest that the proposed method has improved statistical power over single-trait analysis in most of the cases we studied.
Our simulation studies demonstrate that by borrowing information from similar regions , the proposed spatial similarity method improves the efficiency remarkably.
Our simulation studies show substantial increase in the accuracy of estimates in such joint analyses compared to analyses based on genetic subsample alone.
Our simulation study indicates overall good performance of the model , without convergence problems.
Our skin suffers from daily exposure to oxidative stress , primarily from exposure to the sun's damaging ultraviolet ( UV ) rays.
Our society is aging , and this demographic change necessitates that all social workers have basic competency in gerontology.
Our strategy provides a rapid and efficient method to produce biologically active recombinant hLA.
Our studies also revealed that Jagged1 expressed in ECs exerted its pro-apoptotic activity by lowering expression of the anti-apoptotic protein Bcl-2.
Our studies demonstrate that HOTAIR expression is upregulated under hypoxia in colon cancer and several other types of cancer cells.
Our studies demonstrate that impaired SOCS3 feedback leads to permissive IL10 / STAT3 signalling that promotes alternative macrophage activation and pathological neovascularization.
Our studies demonstrate that silica nanoparticles effectively blunt and reverse age-associated bone loss in mice by a mechanism involving promotion of bone formation.
Our studies feature thick sections , large blocks embedded in celloidin , and vascular staining by alkaline phosphatase.
Our studies have correlated the distribution of lipofuscin and A2E across the human and mouse RPE.
Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.
Our studies have sought to further investigate the functional differences in the KLVS variant that result in increased risk of many age-related diseases.
Our studies highlighted the association of epigenetic modifications of DNA with low benzene exposure.
Our studies identify a molecular mechanism for the complex feedback regulation of bile acid synthesis controlled by FXR.
Our studies identify TTR and Klotho as physiological targets of APP that are regulated by soluble APPsβ independent of developmental APP functions.
Our studies indicate that the dramatic decline in the fitness of aged B-lymphopoiesis coincides with altered receptor-associated kinase signaling.
Our studies showed that anthocyanins blocked age-associated cognitive decline and response capacity in senescence accelerated mice.
Our studies show that the reduction of carnosine-propanals is catalyzed by the enzyme aldose reductase ( AR ) .
Our studies suggest a new function for sortilin as a modulator of BACE1 retrograde trafficking and subsequent generation of Aβ.
Our studies support the hypothesis that unique reactive intermediates generated in localized microenvironments of vulnerable tissues promote end-organ damage.
Our study , a component of a larger evaluation , aimed to identify current and projected needs of PLWH receiving HIV community nursing.
Our study adds further evidence to the potential pathophysiologic consequences of beta2-microglobulin accumulation in chronic uraemic patients.
Our study aimed at evaluating olfactory function in MCI and healthy controls in relation to neurocognitive performance and endothelial function.
Our study aimed to replicate the initial report in Chinese population and explore its effect on cognitive performance.
Our study aimed to verify the temporal trends in disability during 1991-2010 in an older Swedish population and to estimate the associated changes in survival.
Our study aims to evaluate the short-term outcomes of VHR in the oldest-old patients.
Our study also shows significant influences of adiposity and physical activity on the pattern of change in QUS measures during childhood.
Our study also shows that higher levels of Hsp70 are associated with inflammation and frailty in elderly patients.
Our study and the recent description of another frameshift mutation in a Chinese ADNSHL family identify OSBPL2 as a novel gene for progressive deafness.
Our study assessed key markers of bone metabolism at time of transplantation and @number@ months after transplantation among @number@ kidney and @number@ liver recipients.
Our study challenges the idea of family-like group living.
Our study comprised @number@ Icelanders whose birth records included anthropometrical data.
Our study concluded that almost half of the rural Thai elderly were physically inactive.
Our study confirmed these results after considering possible confounding factors.
Our study confirms an association between SHS and short RTL.
Our study confirms the protective association between maternal prenatal folic acid supplement use and myelomeningocele among children born in Bangladesh.
Our study covers three health and social service centers in Québec.
Our study demonstrated inhibition of miR-182 can expansively decrease cell proliferation of APL cells.
Our study demonstrated that in AECs , inhibition of MAO-B using selegiline reversed the CSM-induced oxidative stress and inflammation.
Our study demonstrated that oxidative stress , both in serum and tissues in patients with NPs , was higher than in patients without NPs.
Our study demonstrated that PIM-1 is a key component of the senescence machinery that contributes to heterochromatin formation.
Our study demonstrated that the activation of PPAR-γ by pioglitazone protected against oxidative stress damage in aging cerebral arteries by upregulating UCP2.
Our study demonstrates a novel pathway which regulates ΔNp63αupon cellular response to chemotherapeutic agents.
Our study demonstrates sex variations and progressive conjunctival shrinkage with age.
Our study demonstrates that fibrofatty changes can also be seen in pediatric cardiac allografts.
Our study demonstrates that older dolphins have changes in hematological and serum chemistry values similar to those found in older humans.
Our study demonstrates that there are opposing forces that regulate telomere cohesion.
Our study demonstrates the differential involvement of anterior hippocampus in intentional relative to incidental associative encoding.
Our study demonstrates the importance of future self-views on aging for development-related outcomes that have an especially high impact on people's lives.
Our study demonstrates the loss of the homeostatic microglial signature in active multiple sclerosis with restoration associated with disease inactivity.
Our study demonstrates the relevance of multiphoton microscopy to visualize three-dimensional remodeling of the extracellular matrix induced by fibroblast contraction or other processes.
Our study differs from previous studies in that we used a more reliable method that measures both TOS and TAS.
Our study documents substantial impairment of HRQOL in adults with SCD that was influenced by only a few of many possible medical complications.
Our study emphasizes how TOD affects brain network organization and executive control in older adults.
Our study emphasizes that lncRNA may play crucial roles in neurodegenerative diseases.
Our study establishes a molecular mechanism for Aβ-dependent pathogenesis in both DS and AD.
Our study establishes a simple and robust imaging method for precisely monitoring chromatin dynamics in vitro and in vivo.
Our study estimates their impact by assessing what would have been the US public health benefit of routinely vaccinating with QIV in 2000-2013.
Our study examined the relationship between habitual high levels of vigorous physical activity on large and small artery compliance via radial artery pulse wave analysis.
Our study failed to observe this variant in either the longevity subjects or the controls.
Our study findings may have clinical implications.
Our study focused on the association of OPRK1 and OPRM1 methylation with MCI in Xinjiang Uygur and Han populations.
Our study focuses on the role of PERK- and IRE-1-induced arms of UPR in life-or-death decision.
Our study found that the application helped participants to effectively track their medications and improved their sense of wellbeing.
Our study found that two of the nine mouse loci for age-related albuminuria were significantly associated with DN and consistent across male and female strata.
Our study gives evidence that motor intentions become aware before any motor execution.
Our study group comprised @number@ ( @number@ male ) infants with normal VCUG findings who had a renal pelvis of 6-11 mm.
Our study has shown that embryo selection with time-lapse system ( PrimoVision ) enhances the success rate of treatment of aging patients.
Our study has shown that New Zealand University students overestimated the rates of pregnancy for both spontaneous natural and IVF pregnancies.
Our study highlighted the importance of a careful , targeted neoplastic screening.
Our study highlights the importance of developing and sustaining HIV specialist community nursing services for aging PLWH.
Our study highlights the need for accurate diagnosis and treatment of depression in younger-onset patients in order to improve quality of life.
Our study highlights the potential utility of the VACS Index in frailty assessment within the clinical setting.
Our study highlights the role of ApoE in neurogenesis , and shows for the first time an early inequality between the ApoE genotypes.
Our study highlights the value and usefulness of patient-derived cell models in FUS-ALS.
Our study identified rs760678 within NEDD9 gene in association with the risk of AD and cognitive performance in Chinese older persons.
Our study identifies DBC1 as a novel regulator of B cell activation by suppressing the alternative NF-κB pathway.
Our study identifies the alkaloid voacamine as a major compound in Voacanga africana with potent neuroprotective activities in these assays.
Our study included centenarians age 100-115 years diagnosed with the @number@ most common cancers between @number@ and @number@ in the United States.
Our study indicates that COL17 could be an important target of anti-aging strategies in the skin.
Our study indicates that different factors may be important for bone health of men and women and at different ages.
Our study indicates that it is important to look at diseases and health as complex phenomena , which requires integrating different levels of analysis.
Our study indicates that sirtinol has anti-inflammatory effects through direct inhibition of HNE activity and attenuates HNE-induced and LPS-mediated tissue or organ injury in vivo.
Our study indicates that the ADAMTS9 gene may contribute to susceptibility to cognitive aging independently as well as through SNP-SNP interactions.
Our study indicates that the AD-associated genes may contribute to the risk of cognitive aging independently as well as through gene-gene and gene-lifestyle interactions.
Our study indicates that the LLAC measure has good validity and excellent reliability.
Our study indicates the potential contribution of miR-148a to the growth of human prostate cancer.
Our study intent was to assess adolescent regional cerebral blood flow ( rCBF ) as it relates to current and future alcohol use.
Our study is based on data from @number@ million adults aged 25-94 years in the 2010-2014 waves of the American Community Survey.
Our study is the first to investigate the effects of Kundalini yoga ( KY ) training on mild cognitive impairment ( MCI ) .
Our study is the first to suggest that promoting Fbx2 in the brain may represent a novel strategy for the treatment of AD.
Our study may contribute to distinguishing neurodegenerative diseases from normal aging and to predicting cognitive decline.
Our study may suggest that improvement in adipocyte function contributes to the beneficial metabolic effects of coffee consumption.
Our study objective was to formulate recommendations on implementing HF care processes in LTC.
Our study of IgG glycosylation in @number@ individuals from four European populations has revealed very extensive and complex changes in IgG glycosylation with age.
Our study opens a new avenue for regulating metabolism with Nur77 as the positive modulator in the leptin-driven antiobesity in the hypothalamus.
Our study opens the door to an examination of the role of Hb function , within the context of the mitochondrion-in health and disease.
Our study presents the first results with the Hungarian translation of MoCA.
Our study provided insights into the role of aging in the pathogenesis of osteoporosis and some DEGs might be potential biomarkers for osteoporosis.
Our study provides additional evidence for the idea that views on aging shape development , identifying age-related provision making as an important mediating process.
Our study provides a methodology that can be applied effectively to isolate and investigate the effects of age on voluntary and involuntary attention.
Our study provides an organizational framework of theoretical perspectives that can guide further examinations of variation in aging experiences by sexual minority status.
Our study provides a novel regulatory mechanism of miR-1 in the apoptosis of hepatoma cells.
Our study provides further evidence to bolster the claim that carriers of the repeat expansion at C9ORF72 arose from a single common founder.
Our study provides impetus for organizational and / or environmental support systems to facilitate social engagement among poor older adults.
Our study provides new insights into molecular mechanisms underlying BP regulation , and suggests novel transcriptomic markers for the treatment and prevention of hypertension.
Our study provides the first evidence that the tagSNP rs7069102 and haplotype in SIRT1 gene confer susceptibility to MI in the Chinese Han population.
Our study represents the first large-scale clinical study of LRRK2-PD and GBA-PD in ethnic Chinese individuals.
Our study revealed a poorer than expected recruitment rate , but good compliance to , and feedback for , the exercise intervention.
Our study revealed statistically significant increased risk for AMD with aging ( p = 0.00 ) .
Our study revealed that informal care involves huge opportunity costs to the caregivers.
Our study reveals an interaction of cranberry with dietary macronutrients and stresses the importance of considering diet composition in designing interventions for promoting healthy aging.
Our study reveals a novel role for Wt1 in early mammalian development and identifies proteases as critical mediators of the maternal-embryonic interaction.
Our study reveals significant associations between PCC and receipt of preventive services.
Our study reveals that numtogenesis plays an important role in the development of cancer.
Our study reveals that the thickness of skull reaches a steady peak in third to sixth decades.
Our study sample consisted of @number@ subjects with CSF multi-analyte panel data and MRI at baseline downloaded from ADNI.
Our study sample included @number@ participants ( mean age 67A±9 years , @percent@ women ) .
Our study seeks to examine the role of emotional regulation and cognitive control as possible mediators of the association between mindfulness and perceived stress.
Our study showed that ART induced autophagy in breast cancer cells and indicated that the anticancer effects of ART were exerted through an autophagy pathway.
Our study showed that YHK significantly reduced cellular growth in the HuH7 cell line ( p < 0.05 ) .
Our study showed the differential relationship between fat mass and BMD according to gender and menopausal status.
Our study shows that CDT can be utilized to unravel the lifestyle factors associated with cognitive function.
Our study shows that ectopic miR-1 overexpression induced apoptosis of liver hepatocellular carcinoma ( HepG2 ) cells.
Our study shows that Nrf1 could inhibit EpRE activity in vitro , whereas the precise role of Nrf1 in vivo requires further investigations.
Our study shows that protein but not mRNA levels of CREB are reduced in the lungs of old mice.
Our study shows that spatially extended statistics can yield information about regional-specific changes in metabolite concentrations obtained by short echo time MRSI.
Our study shows that the age of target cells at the time of transformation affects B-ALL malignancy.
Our study shows that the concept of body types provides a reliable option for the anthropometric characterization of developing and aging populations.
Our study shows that the DIs robustly characterize accelerated rates of aging irrespective of specific of deficits.
Our study shows that the presence of hypertension is not associated with the plasma levels of visfatin / NAMPT in elderly subjects.
Our study shows that the prevalence of osteoporosis and osteoarthritis is very high , and its impact on quality of life is strong.
Our study shows that these changes , along with the degree of laryngeal cartilages calcification in both genders , occur as a continuum throughout puberty.
Our study shows that the shorter size does in principle provide a selection advantage , which can lead to an accumulation of the deletion mutant.
Our study sought to unravel the relationship between the content of self-generated thoughts and psychosocial stress measured in terms of axis and sympathetic activity.
Our study's premise was that normative care beliefs can inform the current care policy debate.
Our study strongly suggests that analyzing multiple phenotypes can improve statistical power and that such analysis can be executed with the summary statistics from GWASs.
Our study suggested that MSCs derived from bone marrow and placental chorionic villi might be preferred in clinical application for therapeutic angiogenesis.
Our study suggested that the prevalence rate of adult-onset NIID may be higher than previously thought , and that NIID may be underdiagnosed.
Our study suggests an involvement of rare variants within several putatively causal genes underneath previously identified PD GWAS peaks.
Our study suggests high prevalences of spirometric obstruction and smoking in male nursing-home residents in Turkey.
Our study suggests that CB1 receptors are intact in AD and may play a role in preserving cognitive function.
Our study suggests that minoxidil @percent@ lotion is a safe and effective treatment for eyebrow hypotrichosis.
Our study suggests that the blood transcriptome of healthy individuals is reproducible over a time period of several months.
Our study suggests that the increase of α5β1 integrin expression levels enhances CAR expression and thereby improves tumor killing by gCAR-T.
Our study suggests that the operative management of Weber B2 and B3 injuries can result in a favorable outcome.
Our study suggests there is a differential effect of APOE ε4 on brain volume in Chinese versus white cognitively normal elderly adults.
Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.
Our study supports the notion of GAO as a possible treatment for AD.
Our study supports the use of FLAG both financially and as an effective , well-tolerated high-dose treatment regimen for elderly patients with AML.
Our study tested whether OPEL have lesser prevalence of CVD independent of lifestyle factors.
Our study therefore provides evidence for FcγRs , especially FcγRIIB , being involved in the pathogenesis of HT.
Our study , therefore , uncovers the different steps of CSB-mediated chromatin remodeling that can be regulated by NAP1L1.
Our study underscores the distinction between age-related effects on learning vs. performance , and offers practical implications for enhancing skill learning in older adults.
Our study was designed to determine if such collaboration benefits would remain after a one-week delay , in both younger and older adults.
Our study was therefore designed to assess the effect of normal aging on VBR data.
Our subjects were all EPEC trainers and end-learners of our curriculum.
Our sub-study included @number@ randomly selected men and @number@ women aged 61-75 years.
Our suggested GA and HbA1c cut-points for prediabetes at the 75th percentile of the normal population would be @percent@ and @percent@ , respectively.
Our suggestions were guided by a pragmatic approach and aimed at facilitating the implementation of a uniform methodology.
Our survey also revealed that more than @percent@ of the 50- to 69-year-old runners had started their marathon training only in the past @number@ years.
Our survey introduces new discussion about social isolation , privacy , noise levels and patient well-being and recovery.
Our surveys included questions assessing participation levels in Ibasho , demographic characteristics , efficacy , social networks , and a sense of belonging.
Our systematic review of epidemiological data revealed more information gaps than information that would allow gaining a meaningful picture of prevalence of ARHL.
Our target group is Latino immigrants receiving services from a non-profit organization ( NGO ) in Northern California.
Our target recruitment was @number@ cases and controls per disease ; some cases were controls for unrelated diseases.
Our technique generated a highly specific separation of phosphopeptides by an applied pH gradient between @number@ and @number@
Our test results show that a low SWS ratio and sleep apnea can degrade the performance of SWS detection.
Our thematic analysis identified six broad themes that summarized reasons why patients chose to access ED or urgent care.
Our thematic and discursive analyses of the articles generated six themes.
Our timekeeping mechanism is deeply embedded in cell function and is modelled as a network of transcriptional and / or post-translational feedback loops.
Our transcriptomic study provides potential insights into the effects of cigarette smoking on gene expression in whole blood and their relations to smoking-related diseases.
Our understanding of B cells as merely antibody producers is slowly changing.
Our understanding of the biology of aging has advanced significantly in recent years.
Our understanding of the complex molecular signals and mechanisms that regulate and influence the hair follicle has expanded in recent years.
Our understanding of the genesis of this injury and of potential interventions to prevent , limit , or reverse injury / dysfunction is continuously evolving.
Our understanding of the mechanisms controlling gene expression is actually now expanding to a previously unforeseen extent.
Our understanding of the overlap between CR- and T ( b ) -mediated longevity remains incomplete and should be explored in future research.
Our understanding of the situation in older adults , especially the middle-aged is , however , limited.
Our understanding of this crucial modification may even contribute to the treatment and prevention of age-related illnesses in the very near future.
Our unique autopsy source makes possible to collect a fairly number of high quality cases in a short time.
Our unit has been active in providing treatment for acute diseases in elderly individuals in the community.
Our validation sets confirmed the direction of age-related DNA methylation changes in all measured regions.
Our visual world is hierarchically organized.
Our vulnerability argument is partly supported by the findings.
Our whole-brain analysis revealed significant age-related declines in WM integrity , which were more widespread in high relative to low AD risk participants.
Our work adds to studies that demonstrate that fractal analysis has the potential to determine the provenance of paintings.
Our work aimed to link this deterioration to the decline in theory of mind.
Our work aims to bridge the research-to-practice gap to meet the demands of an aging population.
Our work begins to fill this void in three ways.
Our work demonstrates that early developing neural retinas can be divided into two layers , the outer and inner neuroblast layers.
Our work demonstrates that eIF2αP determines cell destiny through its capacity to control senescence in response to oxidative stress.
Our work has important implications in that our data provide further evidence for plasticity of cognitive functions in old age.
Our work highlights the future global disease burden of GCA , and illustrates the associated financial implications.
Our work identifies a novel GS-associated GS activity-modulating component of insulin resistance.
Our work may offer a new clue to a better understanding of aging and AD.
Our work may provide useful information to enable further investigations in multimorbidity research within the scope of potential interactions and chronic pain.
Our work reveals pathways regulated by Arx and Dnmt1 that are sufficient for achieving targeted generation of β cells from adult pancreatic α cells.
Our work suggests to deepen the understanding of the iPSCs biology before considering their use in clinical applications.
Our work with NK cells should contribute toward this goal.
O uso de anti-hipertensivos apresentou associação positiva com sexo feminino , maior faixa etária , cor da pele preta , sobrepeso e histórico de tabagismo.
Outbreaks of nosocomial infections have historically been documented in association with construction and renovation actives within health care facilities.
Outcome assessment included photographic evaluation by two blinded investigators , skin biopsies before and two months after treatment , and patient satisfaction.
Outcome assessments included standardized photography , mexameter , and spectrometer for skin tone , global evaluation by blinded investigators , and patients ' self-assessment.
Outcome assessors and data analysts will be blinded to group assignment.
Outcome comparison included operation time , tumor size , pre- and postoperative serum levels of calcium and PTH and length of stay in hospital.
Outcome data was collected prospectively on length of stay , in-hospital mortality and new institutionalisation.
Outcome data were collected from Minimum Data Set of the Complejo Hospitalario Universitario Albacete.
Outcome following cranial trauma was good in @percent@ of patients.
Outcome following such fractures is affected by age of the patient.
Outcome is improved when active antifungal therapy and surgery are combined.
OUTCOME : Life-space mobility trajectory.
Outcome measure.
OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS : The main outcome was PCSM.
Outcome measurements are conducted at baseline , post intervention and at 6-month follow-up.
Outcome measures included A1C and the modified Physical Performance Test ( mPPT ) .
Outcome measures included center of mass-ankle inclination angles , hip , knee and ankle joint moments , and ground reaction forces of the stance limb.
Outcome measures included cognitive-executive aspects of performance and gait parameters.
Outcome measures included gait under usual-walking and dual-task conditions and while negotiating physical obstacles.
Outcome measures included Menopause-Specific Quality of Life ( MENQOL ) questionnaire , frequency of hot flushes and night sweats and serum estradiol levels.
Outcome measures included postoperative morbidity and mortality.
Outcome measures included spatiotemporal parameters and kinematics.
OUTCOME MEASURES : Myocardial infarction ( MI ) , coronary heart disease ( CHD ) death , disability-adjusted life-years , and costs.
Outcome measures of success , barriers to achieving successful transitional care and effectiveness of interventions are investigated.
OUTCOME MEASURES : Pain reports were dichotomized from a 5-point scale into no / very mild vs moderate and greater.
OUTCOME MEASURES : Prevalence and age were analyzed for each diagnosis group.
OUTCOME MEASURES : Self-rated health and health-related quality of life measures ( 12-Item Short Form Health Survey ) were determined.
OUTCOME MEASURES : The HbA1c response to each DPP-4 inhibitor within @number@ year of therapy.
OUTCOME MEASURES : The main outcome measure was NAFLD score , defined by LUS.
OUTCOME MEASURES : The outcomes were glycaemic control , cardiovascular risk factors and remission from the metabolic syndrome.
OUTCOME MEASURES : The research team chose to focus on @number@ psychological variables of interest for aging populations : morale and self-efficacy.
OUTCOME MEASURES : Trained staff interviewed study participants in their homes using structured questionnaires.
Outcome measures were compound z scores for memory , attention , executive functioning , language , and global cognition.
Outcome measures were degree of satisfaction with health , economic status , housing , neighbor relationships , and family relationships.
Outcome measures were falls during hospital stay.
Outcome measures were given at baseline , and after @number@ and @number@ weeks.
Outcome measures were Glasgow Outcome Scale Extended ( GOSE ; disability ) , SF-12 ( HRQoL ) .
Outcome measures were Logical Memory II , Letter-Number Sequencing , and Spatial Span from the Wechsler Memory Scale.
Outcome measures were mortality , preoperative and postoperative mobility , and loss of independence.
Outcome measures were obtained via telephone questionnaire and graded on a four-point scale.
Outcome measures were related to skin elasticity ( expressed as Young's elasticity modulus ) and skin architecture ( histological analysis ) .
Outcome measures were scores on Mini Mental State Examination ( MMSE ) , ADL , IADL and Neuropsychiatric Inventory ( NPI ) .
Outcome measures were subjects ' sleep quality and cognitive function.
Outcome measures were the proportion of subjects with Alzheimer's disease at the mild cognitive impairment stage and progression to Alzheimer's disease-type dementia.
Outcome measures were the receipt of supportive or palliative home care.
Outcome of interest : change in a measure of physical function or disability between pre-admission or admission , and discharge or post-discharge.
Outcome of interest was elder self-neglect.
OUTCOMES : All aspects related to the experience of UI endured by women were considered.
OUTCOMES : All four national parties integrated policy recommendations from the intervention into their @number@ election platforms.
Outcomes analyses for local flap reconstruction are in high demand.
Outcomes are assessed at baseline , and @number@ @number@ @number@ @number@ and @number@ months.
Outcomes assessed included emotional and cognitive health , physical function , and physical health ( eg , blood pressure ) .
Outcomes assessed over @number@ year were as follows : recurrence ( any ER / admission visit following @date@ surgery , complications , and mortality.
Outcomes assessed were related to medications , reviews , and adverse events.
Outcomes can be maximized because tension exists " invisibly , " only at the fascia level.
OUTCOMES : Clinical features , kidney pathologic characteristics , end-stage renal disease ( ESRD ) , and mortality.
OUTCOMES : Cognitive function as determined by a comprehensive neurocognitive battery , administered at baseline and yearly when possible.
Outcomes differed significantly between clusters.
Outcomes : Difference in change in the QTcF between testosterone and placebo groups was assessed in each trial.
OUTCOMES : Eight therapists completed @number@ workshops and applied the home intervention in @number@ people with stroke.
Outcomes evaluated were recruitment , attendance , resource use , participant satisfaction , and subjective benefit to participants.
Outcomes examined were scores on annual tests of processing speed , verbal episodic memory ( immediate and delayed ) , and working memory.
Outcomes for Mike include both cognitive development and enhanced self-esteem.
Outcomes for these patients are poor compared with those with preceding vascular disease.
OUTCOMES : IELT , MELT , and total testosterone levels.
Outcomes included blood-transfusion rates , length of stay , complications , reintervention rates , and perioperative mortality.
Outcomes included endothelial function , arterial stiffness , biomarkers , HRQoL and markers of anxiety and depression.
Outcomes included illness uncertainty , uncertainty management , depression , anxiety , self-efficacy , and quality of life.
Outcomes included incidence of codes ( cardiac and / or respiratory arrests ) , outcome of the codes , and overall hospital mortality.
Outcomes included in-hospital fatality rate , hospital length of stay , and hospital charges.
Outcomes included lean tissue mass by dual energy x-ray absorptiometry , one-repetition maximum strength , Margaria stair power , and activity questionnaires.
Outcomes included : MMS skills / performance.
Outcomes included observed nurse pain assessment queries and resident reports of pain.
Outcomes included scores on a battery of six cognitive tests at follow-up and having one or more incident impairments in instrumental activities of daily living.
Outcomes included the presence / absence of incontinence and limitations in daily activities due to incontinence.
Outcomes included Timed Up and Go ( TUG ) , gait speed , and gait speed with a cognitive distraction.
Outcomes include effects on perceptions of aging and dementia , behavior , mood , engagement and sense of self.
OUTCOMES : In the follow-up , the right leg weakness was alleviated , and his gait was improved.
OUTCOMES & MEASUREMENTS : eGFR , urine albumin-creatinine ratio ( ACR ) , and risk factors for and complications of CKD.
Outcomes of former phases served as input for subsequent phases.
Outcomes of HF in the elderly have not changed in the past @number@ decades despite the introduction of novel HF therapies.
Outcomes of included studies were combined in a standardised mean difference random-effects meta-analysis.
Outcomes of interest were exercise and leisure walking , walking for errands , and moderate-intensity gardening.
Outcomes of the intervention were measured by the Chinese versions of the Zarit Burden Interview and the Revised Scale for Caregiving Self-efficacy.
OUTCOMES : Pharmacokinetics of selected hormones was determined.
Outcomes representing the volume , pattern and variability of sedentary behaviour and ambulatory activity were derived from the cross-sectional accelerometer data.
OUTCOMES : sCD36 , total and regional fat mass were established by Dual X-ray absorptiometry and magnetic resonance imaging.
OUTCOMES : Sexual activity and physical tenderness ( eg , fondling or kissing ) in the last @number@ months.
Outcomes studies comparing TAVR with medical management demonstrate improved patient survival , functional status , and quality of life.
OUTCOMES : The patient demonstrated increases in lower extremity strength and active range of motion , ambulation distance and speed , and transfer ability.
OUTCOMES : We estimated relative risk ratios ( RRRs ) of overweight / obesity associated with unfavourable SES and lifestyles.
OUTCOMES : We evaluated self-reported cessation rates by day @number@ and after @number@ and @number@ months and stratified the two groups by education levels.
OUTCOMES : We find that estrogens play a leading role in the causes and consequences of female obesity.
Outcomes were also stratified according to health literacy level.
Outcomes were analyzed with multiple Tobit hierarchical regression models , with adjustment for relevant covariates.
Outcomes were any MVC or at-fault MVC in the prior year.
Outcomes were assessed at baseline and after the final therapy.
Outcomes were assessed at baseline and at @number@ @number@ and @number@ weeks of follow-up.
Outcomes were assessed at baseline and @number@ months after the intervention.
Outcomes were assessed by ANCOVA , with Bonferroni-corrected pairwise comparisons.
Outcomes were better in patients with BMI≤30 kg / m2.
Outcomes were categorized as early neurological deterioration ( END ) , hematoma expansion , Glasgow Outcome Scale ( GOS ) , and in-hospital death.
Outcomes were change scores in mobility and activities in daily living ( ADLs ) .
Outcomes were clinical efficacy , nasopharyngeal carriage and immunological response.
Outcomes were clinical scores and major failures.
Outcomes were collected in 2007-2008 and initial analysis performed in @number@
Outcomes were compared using a propensity-matched cohort of patients without intervention.
Outcomes were determined by case notes , clinical review , and a questionnaire.
Outcomes were evaluated for @number@ and @number@ caregivers who completed 6- and 12- month follow-up , respectively.
Outcomes were falls ≥1 time per year and falls ≥2 times per year.
Outcomes were frailty index score or mortality at four-year follow-up.
Outcomes were impairment in @number@ or more activities of daily living and changes in gait speed on a walking test.
Outcomes were low ( < 10th percentile ) , high ( > 90th percentile ) , and mean hematocrit.
Outcomes were measured by wrinkle evaluation of blinded investigators , subjects ' self-assessment , objective measurements of elasticity , and skin biopsy.
Outcomes were measured via validated self-report questionnaires at baseline ( T1 ) and at post-treatment ( T2 ) .
Outcomes were mobility limitations and limitations in instrumental activities of daily living.
Outcomes were predicted by initial eGFR.
Outcomes were prevalent and incident frailty during the 4-year follow-up period.
Outcomes were prevalent frailty and incident frailty at @number@ years of follow-up.
Outcomes were recorded before treatment and after @number@ @number@ @number@ and @number@ days , including glabellar line severity at maximum contraction and relaxation.
Outcomes were regressed on demographics and biomechanical and psychosocial exposures.
Outcomes were self-reported , regarding the 7-day point prevalence on abstinence rate and continuous abstinence rates at @number@ @number@ and @number@ month follow-up periods.
Outcomes will be measured at baseline , after @number@ months , and after @number@ year.
Outcomes will be used to inform care providers , and guide health care policies.
Outcome variables included accelerometer-based physical activity and self-reported transport and leisure walking.
Outcome variables included maximum back extension torque , initial MF-EMG ( IMF-EMG ) , MF-EMG slope declines , and individual MF-EMG muscular imbalance scores.
Outcome variables included measures of strength and performance-based tests of mobility-related activities.
Outcome was assessed at @number@ months as the number of dependent or dead patients ( modified Rankin scale - mRS > @number@ ) .
Outcome was mainly characterized by motor disability and relatively good visual function.
Outcome was self-report of new or worsened disability by @number@ ( difficulty or dependence in any of six activities of daily living ) .
Outdoor activity was an independent risk factor of cortical cataract ( OR = @number@ @percent@ CI @number@.004-1.083 ) .
Outdoor temperature may affect the amount of brown adipose tissue , and the amount is negatively correlated with age and obesity.
Outlier genes were enriched for proximal rare variants , providing a new approach to study large-effect regulatory variants and their relevance to traits.
Outline the components of an evidence-based falls assessment and identify risk factors for falls.2.
Outlining high-risk groups may inform potential screening practices and physician awareness for GC.
Outlook In conclusion , while van der Klink et al's definition of SE ( @number@ ) does have strong merits , it requires further improvement.
Out-migration of adult children was highly associated with poor mental health but it was not associated with the physical health of the elderly left behind.
Out-migration of children was also highly associated with higher utilization of health facilities by the elderly.
Outmigration of youth is an important determinant of the wellbeing of the elderly.
Out of all the bursae surrounding the knee joint , supra-patellar bursitis is most often associated with knee pain.
Out of a potential of @number@ articles , @number@ met the eligibility criteria encompassing @number@ participants.
Out of @number@ elderly who had committed a criminal act @number@ of them had a medical antecedent which is a psychiatric diagnosis.
Out of @number@ identified programs , @number@ programs were investigated in @number@ studies including follow-ups.
Out of @number@ individuals , @number@ ( @percent@ ) were with high-risk diabetes , @percent@ were female , and @percent@ were male.
Out of @number@ initial hits , @number@ studies with a total of @number@ participants ( @number@ with sarcopenia and @number@ without ) were meta-analyzed.
Out of @number@ men , @number@ had IPSS less than @number@ and Qmax less than @number@ mL / s.
Out of @number@ metabolites , @number@ were nominally associated ( p < 0.05 ) with incident MI in KORA S4.
Out of @number@ patients hospitalized , @number@ patients aged @number@ years and over were included in the study.
Out of @number@ patients , @number@ had some degree of handicap ranging from mild to severe.
Out of @number@ potential studies , @number@ publications ( with @number@ distinct effect size data points ) met all inclusion criteria.
Out of @number@ subjects , @number@ ( @percent@ ) developed delirium.
Out of @number@ workers selected using systematic sampling , @number@ workers were enrolled in the study.
Out-of-pocket expenditure predominantly concerned the cost of private care workers.
Out-of-pocket expenses posed greater problems in the United States than elsewhere.
Out of the @number@ deaths , cancers accounted for @percent@.
Out of the @number@ HC subjects , @number@ subjects converted to MCI or AD dementia.
Out of the @number@ patients who entered the study , @number@ dropped out during the study ( @percent@ ) , leaving @number@ patients.
Out of the patients with swallowing dysfunction , @percent@ had an overall improved swallowing function with carbonated liquid.
Out of the sample , @percent@ ( 781 / 898 ) were students.
Out of this , the cost borne by the public sector was €4 , 534 / yr.
Out of total @number@ subjects with symptoms of RTls / STls only about one-third ( @percent@ ) had sought treatment.
Out of which frequency of geriatric patients were @number@ which constitute about @percent@.
Outpatient anaesthesia for elderly patients requires greater specific knowledge and skills.
Outpatient anticoagulation in the geriatric trauma patient is a challenging clinical problem.
Outside of skin cancer prevention efforts we have as a specialty primarily worked on the tertiary prevention realm.
Outstanding issues in the field are addressed and productive avenues of future research are suggested.
Outstanding skills , including special isolated skills ( SIS ) and perceptual peaks ( PP ) are frequent features of autism.
Ovarian aging is associated with gradual follicular loss by atresia / apoptosis.
Ovarian aging is characterized by both a reduction in egg quality and a drastic reduction in the number of ovarian follicles.
Ovarian function has not been studied.
Ovarian function was assessed in @number@ tall women ( @number@ treated , @number@ untreated ) .
Ovarian hormones , particularly at pregnancy levels , were identified as modulators of COX-2 in normal mammary epithelium.
Ovarian primordial follicle count was then determined using a validated fractionator / optical disector method.
Ovarian reserve and its utilization , over a reproductive life span , are determined by genetic , epigenetic , and environmental factors.
Ovarian reserve markers in isolation may not serve as predictors of future fertility.
Ovarian reserve tests ( ORT ) include serum and ultrasound biomarkers used in characterizing healthy ovarian aging and predicting ovarian reserve prior to fertility treatment.
Ovarian reserve was examined at a random cycle day.
Ovarian steroid cell tumors are very rare but potentially life-threatening neoplasms.
Ovarian tissue collection is independent of patient age and social or personal conditions.
Ovarian volume , inhibin B , estradiol , and follicle-stimulating hormone are less helpful.
Ovariectomized rodent models of rapid bone loss due to estrogen-deficiency reported that RES supplementation improved bone mass and trabecular bone without stimulating other estrogen-sensitive tissues.
Ovariectomy also led to downregulation of aromatase and upregulation of ERα gene.
Ovariectomy upregulated Cd22 and downregulated semaphorin3A ( Sema3a ) expression , indicating altered neuronal regulation of microglia.
Over a 14-year period , mobility and self-care deteriorated ( Barthel Index , @number@.1±4.8 to @number@.3±5.6 ; P = .007 ) .
Over a 6-year period , living alone was related to a half year reduction in survival among elderly people in Sweden.
Over-activated neutrophils produce enormous oxidative stress and play a key role in the development of acute and chronic inflammatory diseases.
Overactivation of Wnt / βcatenin signalling in a spermatogonial cell line resulted in reduced cell proliferation , viability and colony formation.
Overactivation of μ-calpain was confirmed using proteolytic fragments of its substrate spectrin.
Overactive bladder ( OAB ) is a common condition , with prevalence rates increasing with advancing age.
Overactive bladder ( OAB ) is a highly prevalent clinical condition in both men and women , and rates tend to increase with advancing age.
Overactive or unresolved inflammation is the primary determinant in heart failure pathology post-MI.
Overactivity of CMA can be associated with tubular lysosomal pathology and certain cancers.
Overall , ≥10 recommended procedures were followed by @percent@ of the participants ; only @percent@ followed all recommendations.
Overall 10-year mortality was @percent@.
Overall 1-year postoperative mortality was @percent@ and mortality after hip fracture at the end of the follow-up was @percent@.
Overall 255 / 493 ( @percent@ ) HF events occurred in participants with SBP < 140 mm Hg at baseline.
Overall 3-year survival was higher for patients with other insurance compared with Medicaid-insured ( @percent@ units ) and uninsured ( @percent@ units ) patients.
Overall 5-year relative survival for patients with HL in Germany was 84·3% , compared to 80·6% for the US.
Overall 5-year RS was slightly higher in Germany compared to the US.
Overall-5-year survival rate was @percent@.
Overall , 917 / 4345 ( @number@ % ) randomised patients in the seven trials were elderly ( @number@ IDeg , @number@ IGlar ) .
Overall , about @percent@ of both genders reported that they were highly concerned that current sun exposure could cause skin cancer.
Overall , accuracy and confidence jointly influence age-related changes to destination memory , a fundamental component of successful communication.
Overall achievement was lower for participants who were men , wealthier , infrequent alcohol drinkers , not obese and living alone.
Overall , acquisition and protocol changes require careful adaptations of the VBM analysis strategy before generalized conclusion can be drawn.
Overall , AD and DLB are characterized by different spatiotemporal patterns of cortical thinning over time.
Overall adherence to the WHO guidelines for feeding in the first semester of infancy was much less than ideal and in need of strengthening.
Overall , affective , and somatic depressive symptom scores were computed using the 20-item Center for Epidemiologic Studies Depression Scale.
Overall , age adjusted 5-year relative survival increased , from @percent@ in 1998-2001 to @percent@ in 2006-2009.
Overall , age- , gender- , and group-specific mortality rates were calculated.
Overall age standardized 5-year relative survival was @percent@.
Overall , aging appeared to affect the limbic area and its implication to emotional processing.
Overall agreement was @percent@ ; kappa was @number@
Overall aim is to prevent or attenuate decline of key physiological functions required to live an active , independent life.
Overall , alcohol intake was not associated with WMHV or brain infarcts.
Overall , a long post-reproductive stage promoted the evolution of cooperation , while a prolonged pre-reproductive stage has a negative effect.
Overall AMS score after the treatment rose more in patients of groups @number@ and @number@ ( p < @number@ ) .
Overall and disease-specific mortalities of Olympians were compared with those of the French general population through standardized mortality ratios ( SMRs ) and @percent@ CIs.
Overall and disease-specific mortalities were calculated through standardised mortality ratios ( SMRs ) with its @percent@ confidence intervals ( CIs ) .
Overall and in individual groups , a negative correlation of mGluR2 / 3 density and age at death has been found.
Overall and in sex-stratified analyses , race was not associated with recovery from depression or with the transition from depression to death.
Overall , androgyny was associated with better mobility and physical and mental health.
Overall , a negative correlation was found between cortisol output during the fMRI experiment and brain activation magnitude during performance of a gambling task.
Overall , a reduction in pigment was observed with both treatment arms during the study period.
Overall , a series of proactive strategies were adopted to mitigate risk of contact.
Overall associations between sVCAM-1 and BC exposures were suggestive but not statistically significant.
Overall , at both T0 and T1 , the distress level was moderate among caregivers and mild among health care staff.
Overall balance of clinical outcomes has not been evaluated.
Overall , behavioural and neuropsychiatric symptoms of dementia symptoms are common among the three groups of dementia patients.
Overall , bilingual dementia cases were significantly better educated than monolinguals , but U.S. born bilinguals and monolinguals did not differ significantly in education.
Overall , both young and older adult groups showed robust observation inflation.
Overall , BP control among all hypertensives increased from @percent@ to @percent@.
Overall , BT trials yield medium to large effects for TS that are comparable to treatment effects identified by meta-analyses of antipsychotic medication RCTs.
Overall , cancer caused @number@ million DALYs worldwide in @number@ for both sexes combined.
Overall cancer mortality decreases both in the male and the female population.
Overall changes after the exercise intervention in serum biomarkers were not associated with changes in functional capacity and cognitive measures.
Overall , changes in several molecular phospholipids were seen with age in the entorhinal cortex across both membranes.
Overall , children's response bias scores were stronger for familiar objects than for unfamiliar objects.
Overall cognitive functioning and specific cognitive domains were assessed from data of a self-assembled neuropsychological battery of frequently used tasks.
Overall , completion rates averaged @percent@ , with Native Hawaiian / Pacific Islanders completing workshops at a higher rate ( @percent@ ) than other groups.
Overall , confidence was related to error correction for younger adults , but this relationship was much smaller for older adults.
Overall confirmed hypoglycaemia was defined as < 3.1 mmol / L or severe hypoglycaemia ( symptoms requiring external assistance ) .
Overall , contrast-to-noise ratios ( CNR ) were higher in QSM than in T2 -weighted images.
Overall conversion rate was of @percent@ , most in the group 65-79 years ( @percent@ of all conversions ) .
Overall , cumulative incidence was uniformly higher in NACC than in the population-based cohorts.
Overall , dating threatens parent-child relationships in specific cases , yet it may also strengthen widow ( er ) s ' parent-child bonds.
Overall , developmental changes were most evident when the probability of specific behaviors was examined in specific interactive contexts.
Overall , diagnoses were revised in @percent@ of the cases.
Overall disease activity and / or pain may be overestimated , as elderly patients may suffer from other diseases.
Overall , disease penetrance in LRRK2 carriers was @percent@ by @number@ years but women become affected a median @number@ years younger than men.
Overall , DSC MR-perfusion enables an in vivo evaluation of the hemodynamic state of CP.
Overall , DXA-derived indices may provide a useful assessment of bone geometry , density , and theoretical strength contingent on appropriate consideration of their limitations.
Overall , efficacy data support the use of some psychotropic medications , including selective serotonin reuptake inhibitors , serotonin-norepinephrine reuptake inhibitors and gabapentin.
Overall , elderly patients with advanced NSCLC , while experiencing greater toxicity , demonstrate the same response rates and survival benefits as their younger peers.
Overall , EM varied from @percent@ to @percent@ , depending on the defining criteria.
Overall enzyme activity was significantly elevated in the MCI cohort in both cortical regions compared to the NCI cohort.
Overall , epigenetic modifications seem to play a major role in cancer , influencing tumour outcome by interfering with key senescence pathways.
Overall , ethnicity remained a significant predictor of ageing perceptions when other resources were taken into account.
Overall , evidence supports the prescription of eccentric exercise for the majority of outcomes of interest in the diverse cohorts of the older adult population.
Overall , F6H8 ( NovaTears ) seems to be safe and effective in treating mild to moderate hyperevaporative DED.
Overall , familial and sporadic ET cases share very similar cerebellar postmortem features.
Overall family and practice commitments along with compensation were the primary barriers to teaching part time.
Overall , family caregivers reported having some preparation to provide care ; the most difficult caregiving activity was identified as managing behavioral problems.
Overall , FeNO levels increased with increasing age ( p < @number@ ) , and height ( p < @number@ ) .
Overall filial discrepancy was evaluated by filial receipt minus expectations.
Overall findings based on linear regression analyses reveal that the mental distress resulting from the perception of physically deteriorating neighborhood declines with age.
Overall , forty-eight patients ( @percent@ ) received diagnoses of MCI or dementia.
Overall , four dietary patterns were identified : the ' Western' ; ' Vegetarian' ; ' Continental' ; ' High-protein'.
Overall , Friedewald LDL-C levels are lower compared with the direct measurement , especially with increasing triglyceride levels.
Overall , generalists had a more positive attitude towards screening than specialists.
Overall , geriatricians had more confidence and more knowledge in caring for older hospitalized adults.
Overall GMS medicines costs are projected to rise to €1.9bn by @number@
Overall , grandchild production was not improved by living beyond @number@ years and was reduced by living beyond @number@
Overall , groups sealed showed the highest fluorescence intensity compared with unsealed groups.
Overall , HA gel injections were generally well tolerated and efficacious for rejuvenation of aging hands compared with saline.
Overall , HCPs only recommended vaginal estrogen therapy to @percent@ and oral hormone therapies to @percent@ of women.
Overall healthcare utilization increases more rapidly among the high users compared to the low users.
Overall , hearing loss seemed to have a greater impact on social function than did visual impairment.
Overall height and magnitude of the lower one-third also increased with aging.
Overall , hippocampal subfield analysis has proven to be a promising technique in the study of AD.
Overall hospitalization rates decreased among HIV-infected and uninfected patients.
Overall , however , selected PPARγ modulators appear to act as hair growth inhibitors that reduce the proliferation and promote apoptosis of hair matrix keratinocytes.
Overall , hypertension ( @percent@ ) , obesity ( @percent@ ) , and heart diseases ( @percent@ ) were the most prevalent conditions.
Overall , ibogaine acts as a pro-antioxidant by increasing activity of antioxidative enzymes and as an adaptagene in oxidative distress.
Overall impression of EEG may be predictive of clinical outcome , even when individual parameters were not predictive.
Overall improvement increased with increasing number of treatments.
Overall , infants / children and juveniles / adolescents displayed higher parasite loads than adults.
Overall , infectious diseases , particularly those associated with HIV , were the leading cause of admission.
Overall , infrared meibography should be included in routine examination of patients undergoing aSCT and during follow-up.
Overall , in-hospital mortality was @percent@.
Overall in-hospital mortality was @percent@ ( @number@ out of @number@ patients ) .
Overall , in-hospital patient mortality rates have been reported to be as high as @percent@.
Overall , in most occasions male increments in nasal dimensions were larger than female ones.
Overall , it appears that the greatest and most clinically meaningful differences between the diagnostic groups were detected in the first three 15-second intervals.
Overall , it had excellent efficacy for improving erythema , telangiectasias , and skin texture.
Overall , it is estimated that there were @number@ fewer driver deaths in @number@ than there would have been had vehicle designs not changed.
Overall , it seems that older adults utilize simpler sets of information primarily reflecting the most valued attributes in making their choice.
Overall , Ku function is critical to the maintenance of genomic integrity and to proper cellular and organismal development.
Overall large randomised controlled trials of exogenous testosterone show benefits over placebo on sexual desire , arousal , orgasm , pleasure and satisfaction.
Overall LS and all aspects of LS except finances , religion , and self-esteem predicted death in unadjusted analyses.
Overall , Lycogen ( TM ) had proven effectiveness on anti-oxidation as patients who used the Lycogen TM -containing product had better outcomes.
Overall major complication rate was @percent@.
Overall , mammalian cells have a large number of disulfide-containing proteins , the folding of which involves non-native disulfide bond isomerization.
Overall , masters athletes should be encouraged to remain active and fit to enhance their quality of life and reduce the risk of cardiovascular disease.
Overall mean TTT was @number@ h , @number@ min.
Overall , memory performance on generated words decreased with age , but the benefit from self-generation remained consistently significant across ages.
Overall mental health was measured on a 10-item Kessler Psychological Distress Scale.
Overall , mirror-style response increased with age , and was predominant for children and an adult comparison group.
Overall , mortality rates are heterogeneous throughout Portugal.
Overall mortality rate was measured over a 12-month follow-up period after the baseline assessment visit.
Overall mortality rate was @number@ % : @number@ % in acute cholangitis , @number@ % in acute cholecystitis , and @number@ % in acute pancreatitis.
Overall mortality was @number@ per cent.
Overall mortality was @percent@.
Overall mortality was @percent@.
Overall , MPP use and administration was well tolerated.
Overall , music therapy and behavioural management techniques were effective for reducing BPSD.
Overall need for greater professional and organizational capacity to support provision of service to both aging and disability populations is reported.
Overall , neutrophil function was preserved in caregivers with neutrophil phagocytosis compromised only in those with the highest levels of distress.
Overall , non-experts under-rated the level of impairment compared with experts.
Overall , @number@ deaths were recorded during follow-up ( Nurses ' Health Study , 1989-2010 ; ESTHER , 2000-2015 ) .
Overall , @number@ elder adults entered the study , @number@ of them ( @percent@ ) frail.
Overall , @number@ factors were rated as the most impactful on PA behaviours across the life course and being the most modifiable.
Overall , @number@ falls occurred during the study.
Overall , @number@ individuals died from CVD.
Overall , @number@ issues of the five magazines with a total of @number@ articles and @number@ advertisements were analyzed.
Overall @number@ lymph nodes were removed ( @number@ in Monza , @number@ in Rome ) .
Overall @number@ @number@ @number@ and @percent@ of the participants were lost to follow-up after one to four interventions , respectively.
Overall , @number@ OAB patients were enrolled.
Overall , @number@ % of patients were receiving long-term PPI treatment.
Overall , @number@ % of residents with daily recurring pain have been pain sufferers for at least one year.
Overall , @number@ older adults who underwent hip fracture surgery were assessed at predischarge and postdischarge.
Overall , @number@ owners returned the questionnaire.
Overall , @number@ participants ( @number@ men ; @number@ women ) with a mean age of 60·6 ( sd 9·1 ) years were included.
Overall , @number@ patients met our inclusion criteria.
Overall , @number@ patients were enrolled in the study , of which @number@ were included in the safety analyses and @number@ in the effectiveness analyses.
Overall , @number@ patients were incident users of antiosteoporotic drugs.
Overall , @number@ ( @percent@ ) were taking at least one anticholinergic drug.
Overall , @number@ research volunteers with HS-Aging and @number@ controls were included ; detailed neuropathologic data were available for all.
Overall , @number@ schizophrenia patients using quetiapine or who had switched to quetiapine were included.
Overall @number@ SNPs were analyzed , out of which @number@ returned RegulomeDB scores of 1-6.
Overall , @number@ studies demonstrated significant reductions in delirium incidence ( odds ratio [ OR ] , @number@ @percent@ CI , @number@.38-0.58 ) .
Overall , @number@ studies evaluating @number@ autoantibody markers were included.
Overall , @number@ studies evaluating @number@ blood-based markers were identified.
Overall , @number@ studies that investigated miRNA expression in tissue and @number@ studies that investigated miRNA levels in plasma were included.
Overall , @number@ studies were included , of which @number@ were eligible for meta-analysis , including two longitudinal studies.
Overall , @number@ subjects ( @percent@ ) and @number@ controls ( @percent@ ) were conceived by in vitro fertilization or intracytoplasmic sperm injection.
Overall , @number@ subjects suffered a non-fatal or fatal stroke during @number@ person-years of follow-up.
Overall , @number@ testosterone , @number@ estradiol , @number@ progesterone , and @number@ DHEA measurements are publically available for Wave @number@ analyses.
Overall , @number@ themes emerged : program design , outcomes for child or youth participants , and outcomes for persons with dementia.
Overall , @number@ women were included in the analyses.
Overall , nurses performed care coordination in both AIP and HHC , but the aggregated dose across Omaha problems and categories is larger in AIP.
Overall , older participants suffering from depression show a high degree of dysregulation of HPA axis activity , with differences compared with younger adults.
Overall , older subjects required longer stimulus durations than younger subjects in all conditions.
Overall , only @percent@ had a living will and @percent@ had a health care representative document in the medical record.
Overall , only @percent@ of the sample participated in a nondegree educational program.
Overall , only @percent@ of the total population ( n @number@ ) achieved the recommended daily dairy intake of three or more servings per day.
Overall , our analyses suggest cautious optimism for cognitive activities , especially game playing , as a strategy for preserving cognitive strengths in midlife.
Overall , our data indicate that molecular targeting of FOXO1 may improve the quality of healing and reduce pathological scarring.
Overall , our data suggest that the aged nonhematopoietic environment is responsible for the impaired maturation and function of NK cells.
Overall , our findings identify polyglutamine-dependent inhibition of nucleocytoplasmic transport and alteration of nuclear integrity as a central component of Huntington's disease.
Overall our findings suggest a high probability that these mutations are pathogenic.
Overall , our model supports the hypothesis that glioma is caused by randomly-occurring oncogenic mutations within the neural stem cell population.
Overall , our results contribute to the current understanding of elastogenesis and provide an animal model of ARCL1C.
Overall , our results indicate that elevated Hcy is prevalent in the children and adults in this rural Chinese population.
Overall , our results indicate that gut CD8 + T cells show profiles suggestive of greater differentiation and activation than those in peripheral blood.
Overall , our results indicate that unlike the widely present DNA damage response marker γH2AX , SAHF is not a common feature of cellular senescence.
Overall , our results provide compelling evidence for positive selection acting on some somatic mtDNA mutations.
Overall , our results suggest that robots could successfully engage older adults in partner dance-based exercise.
Overall , our results suggest that the age-related impairment in recollection is linked with reduced hippocampal structural integrity.
Overall , our studies demonstrate that histone methyl-transferase MLL1 coordinates with HIF1α and histone acetyltransferase p300 and regulate hypoxia-induced HOTAIR expression.
Overall , our study shows that for middle-aged individuals DNAmAge calculated in blood does not correlate with cognitive abilities.
Overall , participants considered a fall prediction system to be as important as a fall detection system.
Overall , participants experienced a reduction in falls , improved selfperception of gait and balance , and improved dynamic gait function.
Overall , participants favored protection over autonomy in responding to the case scenarios.
Overall , participants had a median of five health conditions.
Overall , participants responded positively on the usability and acceptability questionnaire.
Overall , participants utilized external strategies @percent@ of the time on the RPA-ProMem.
Overall , participants were satisfied with both program formats.
Overall participation and home visit participation remained high ( @number@ and @percent@ , respectively ) and there were no gender differences.
Overall patient management , including patient selection , preoperative preparation , postoperative care , and potential complications are discussed.
Overall , patients tolerated this type of treatment well.
Overall , patients with COPD have a 2-3-fold increased risk of CVD as compared to age-matched controls when adjusted for tobacco smoking.
Overall , patients with LBP tended to have smaller LLA than healthy controls.
Overall , patterns of associations were similar across subgroups.
Overall PA was higher among the youngest age group.
Overall PA was measured as counts per minute ( CPM ) and steps.
Overall , @percent@ ( 291 / 1598 ) of participants had at least one hospital admission during @number@
Overall , @percent@ ( 6 / 64 ) of patients had CKD at baseline.
Overall @percent@ expected improvement and @percent@ decline ; however , @percent@ expected no changes in any of the five dimensions of EQ-5D within @number@ months.
Overall , @percent@ of adults failed to meet the daily potassium recommendation of @number@ mmol / d.
Overall , @percent@ of case mothers reported using folic acid supplements during pregnancy compared to @percent@ of control mothers ( p = @number@ ) .
Overall , @percent@ of drivers sustained an UEI.
Overall , @percent@ of men and @percent@ of women considered shopping difficult.
Overall , @percent@ of our participants were nonfrail , @percent@ were prefrail , and @percent@ were frail.
Overall , @percent@ of participants had salt intakes above @number@ g / day.
Overall , @percent@ of patients spent the whole period of their final month of life in-hospital.
Overall , @percent@ of patients were mostly or very satisfied.
Overall , @percent@ of patients with vocal fold paralysis required surgical intervention ( UVFP @percent@ , BVFP @percent@ ) .
Overall , @percent@ of people with hypertension , @percent@ with diabetes , and @percent@ with high cholesterol received pharmacological treatment.
Overall , @percent@ of subjects had a duration of ≥ @number@ days.
Overall , @percent@ of subjects were satisfied with the treatment outcome and would recommend the treatment to friends and family.
Overall , @percent@ of the counties in the United States lacked female pelvic surgeons.
Overall , @percent@ of them engaged in regular physical exercise.
Overall , @percent@ of the older people were exposed to potentially inappropriate drug use by at least one of the five sets of criteria.
Overall , @percent@ of the participants indicated that they wanted to be screened for Alzheimer's disease on a regular basis.
Overall , @percent@ of the sample self-reported their general health status to be fair to poor.
Overall , @percent@ of up-titrated patients achieved target urate levels with median final allopurinol dose of @number@ mg daily.
Overall , @percent@ of women experienced pelvic floor dysfunction of at least one major type.
Overall , @percent@ of women had no formal education , @percent@ had mothers with no formal education and @percent@ of women had low lifecourse SES.
Overall , @percent@ , @percent@ and @percent@ of the respondents were disabled by cardiovascular , musculoskeletal and sensorial diseases , respectively.
Overall , @percent@ ( @percent@ CI @date@ @percent@ ) of participants developed high 10-year predicted ASCVD risk.
Overall @percent@ rated their health as good however parental loss predicted poorer adult health , as did early hunger but not witnessing violence.
Overall , @percent@ reported functional improvement during rehabilitation , and @percent@ reported meeting their goals by discharge.
Overall , @percent@ reported unmet need for assistance for one or more ADL disabilities.
Overall , @percent@ were successfully treated without need for surgery.
Overall , performance was best in the anechoic condition and worst in the high-reverberation condition.
Overall , peripapillary scleral structural stiffness increases significantly with age.
Overall , philanthropy has played a pivotal role in building capacity , infrastructure , and expertise in academic settings in Ireland.
Overall photoaging severity was evaluated in the three groups by the dermatologists at D0 , D30 , and D90 based on the Larnier's scale.
Overall , poor sense of smell , as indicated by a lower BSIT score , was associated with higher risk of PD.
Overall population growth will outpace the growth of available donor organs and thus potentially exacerbate the existing liver graft shortage.
Overall , positive marital quality of both spouses contributes to health protection for middle-aged and older spouses.
Overall , present findings demonstrate that a period of sleep does not significantly promote insight in problem solving in older adults.
Overall prevalence of depression was @percent@.
Overall prevalence of frailty was @percent@ ( n = 17 ) .
Overall , providers ' comfort level in referring patients to CHWs was very high.
Overall , psychosocial and sociodemographic factors played a far bigger role in FoR than clinical factors.
Overall , PTC tasters had fewer confusions than non-tasters except for salty-bitter confusions.
Overall QoL in terms of mental functioning in both rheumatic diseases was assessed at a higher level than in the area of physical functioning.
Overall rate of early and late complications as well as adverse events was lower with Uma Jeunesse® than Juvéderm ( ® ) .
Overall raw point estimates of each risk factor and associated @percent@ confidence intervals ( CI ) were calculated.
Overall , reducing or increasing the original cut-off value by one point did not result in improved performance.
Overall regression analysis demonstrated yearly telomere reduction rate of @number@ base pairs in the myocardium.
Overall response rate was @percent@.
Overall , results indicate that RSNs show different aging trajectories for males and females.
Overall , results suggest that LSF processing is well preserved in AMD patients and allows efficient scene categorization in their parafoveal residual vision.
Overall results suggest that the relationship of CL with REE and its clinical importance in therapeutic proteins need to be investigated further for pediatric subjects.
Overall , results support both the frontal aging hypothesis and processing speed theory , suggesting that each mechanism is contributing to age-related cognitive decline.
Overall results supported persistent anomalous neurodevelopmental maturation across the life span in SBM that related to diminished cognitive control.
Overall , Retinol @number@.2% / LR2412 @percent@ cream was better tolerated than tretinoin @percent@ cream.
Overall , SF and EF were both generally stable between @number@ and @number@ yr following RP.
Overall skin quality across all three treatment areas was judged to be improved on the treated side in over @percent@ of subjects throughout the study.
Overall , social stimuli have the highest impact on affect in persons with dementia.
Overall specificities of FGF21 and GDF15 to find patients with mitochondrial myopathy were @percent@ vs @percent@ , and sensitivities @percent@ and @percent@ , respectively.
Overall , ST188 was the most predominant sequence type.
Overall , stiffness increased and areal strain decreased with calcification severity.
Overall , strains in the peripapillary sclera decrease significantly with age.
Overall stroke risk was lower in hyperthyroid non-self-limiting AF patients compared with nonhyperthyroid counterparts.
Overall , studies showed generally high methodological quality ( average PEDro score = @number@ ) .
Overall , subjects were satisfied with their appearance.
Overall , suboptimal prescribing and the occurrence of adverse drug reactions ( ADRs ) may negatively affect functional status.
Overall , successful recanalization rates were @percent@ and futile recanalization reached @percent@ without statistically significant differences between both groups.
Overall , such results contribute to explaining the vascular protective effects by olive oil polyphenols in Mediterranean diets.
Overall , supercomplex content was increased after exercise.
Overall survival , as a function of age ( discreet and continuous ) , was assessed.
Overall , survival correlated strongly with telomere length.
Overall survival of cancer patients has significantly improved therefore cancer has become in many cases a chronic disease.
Overall survival of EGFR-mutated patients was @number@ months as compared to @number@ months in wild-type.
Overall survival ( OS ) for the entire cohort was @number@.6months ( m ) .
Overall survival rates at @number@ and @number@ years were @percent@ and @percent@ , respectively.
Overall survival was estimated using the Kaplan-Meier method.
Overall telomere shortening was also associated with pulmonary dysfunction.
Overall , tenderness , juiciness , and flavor liking of beef were evaluated by consumers ( n = @number@ ) using 9-point scales.
Overall , the ADSC group showed higher collagen density and had better outcomes in the tropoelastin and fibrillin-1 assessments.
Overall , the airway mechanical characteristics as well as lung function are compromised due to aging.
Overall , the anterior shift of the map in older adults may reflect an adaptive change that allowed for the maintenance of strength.
Overall , the articles highlight the lens as a continuing , very important and attractive model system for biologists working in many different research areas.
Overall , the associations were similar for cardiovascular and noncardiovascular-related deaths.
Overall , the availability of data on age and aging is satisfactory in Germany.
Overall , the availability of the NOACs has expanded the treatment armamentarium , but they are not without risk.
Overall , the available studies support the notion that active participation in verbal encoding engages memory mechanisms that supplement those used during passive observation.
Overall , the clinical data available suggest that strontium ranelate is an effective and generally well tolerated option for the first-line treatment of postmenopausal osteoporosis.
Overall , the correlations to AIX were better than to PWV , with correlations coefficients > 0.70 for EEI , AI and b / a.
Overall , the data presented in this study suggest that non-B DNA conformations are a key element of the mtDNA deletion process.
Overall , the data support the hypothesis that patients with complicated clinical outcomes are exhibiting PICS.
Overall the dwelling check was rated @number@ out of @number@ by the interviewees and may therefore be considered of added value.
Overall , the erector spinae and rectus femoris peak amplitudes were relatively small.
Overall , the filler appears to be well tolerated.
Overall , the findings are inconsistent with any categorical claim that younger adults can bypass the dual-task bottleneck whereas older adults cannot.
Overall , the findings show that the scales do not clearly distinguish between FLEX and TEN.
Overall , the findings suggest a complex relationship between age and movement-related activity in electrophysiological and hemodynamic measures.
Overall , the findings suggest that speed and accuracy may be affected differently during dual tasking.
Overall , the findings were similar for augmentation pressure.
Overall , the function of p62 / SQSTM1 in the proteasomal pathway and autophagy requires further elucidation.
Overall , the gain in life expectancy in men undergoing RP compared with the general population was @number@ years.
Overall , the health benefits of continued sports and athletic participation outweigh the potential risks of spinal degeneration in middle-aged athletes.
Overall , the incidence of wound dehiscence was @number@ percent ( n = @number@ ) .
Overall , the internal health locus of control was associated with higher and the external ' powerful others ' locus with lower risk of depression.
Overall , the main findings of the selected studies appeared to be mainly confirmatory of the previous evidence.
Overall , the MAPIT appeared to yield reliable measures of two aspects of inhibition that demonstrate a differential impact of age.
Overall , the mean age of the samples was @number@ years , and @percent@ were female.
Overall , the mean PEFR is @number@.37±68.14.
Overall , the mediators explained @percent@ of the relationship.
Overall , the pathways common to all @number@ types of senescence were related to inflammation and the innate immune system.
Overall , the pattern of variability was similar in both groups.
Overall , the pharmacodynamic effects of THC were smaller than effects previously reported in young adults.
Overall , the present findings confirm and extend the role of the CC in dementia and age-associated cognitive and motor deficits.
Overall , the prevalence of functional impairment was @percent@ , depressive symptoms @percent@ , cognitive impairment @percent@ , and abnormal timed up-and-go test @percent@.
Overall , the probes developed in this study are valuable tools for the study of cathepsin X function.
Overall , the proportion of memories reported before the age of @number@ years was greater for the children and adolescents relative to the adults.
Overall the QoL in both study groups was of medium level.
Overall , the quality of sperm decreases progressively with age , without any age limit that can be individualized.
Overall , the reduced set of items demonstrated strong psychometric properties.
Overall , there is a genuine need to treat cognitive deficits associated with many neuropsychiatric conditions as well as an increasingly aging population.
Overall , there is a significant lack of scientific and medical research on menopausal women in Costa Rica.
Overall , there is considerable income-related inequality in dental service utilization by several elderly populations residing in Europe.
Overall there is little evidence that common genetic and environmental factors account for the co-occurrence of depression and diabetes in middle aged men.
Overall , there is no need for reduced mobility to reinforce the frailty stereotype ; both are potentially modifiable and amenable to intervention strategies.
Overall there is the belief that not enabling access to funded , insured homebirth in Australia is a violation of human rights.
Overall , the reported atrophy patterns are in close agreement with those mentioned in previous findings.
Overall , the response rate ( ORR ) was @percent@ , disease control rate @percent@ and median progression-free survival ( PFS ) @number@ months.
Overall , the results argue that some , but not all , aspects of expression-context interactions are mature by @number@ years of age.
Overall , the results of this study show the JM product to be equivalent if not superior to @percent@ hydroquinone for results and patient satisfaction.
Overall , there was a significant deterioration in participation ( P < @number@ ) .
Overall , there was a significant effect of body mass index on interest in program participation ( p = @number@ ) .
Overall , there was congruence between documented medical orders and treatment received.
Overall there were no significant differences between the measured and stated energy contents of the QSR foods.
Overall there were @number@ references to home birth in the submissions.
Overall , these data indicate that deficits in semantic clustering are present in aMCI patients.
Overall , these data provide insight into the anti-aging effects of continuous LED irradiation on human skin.
Overall , these data suggest that PDGF and PDGFR-α may be involved in the pathophysiology of the human thymus.
Overall , these findings demonstrate adult age differences in the controlled retrieval of temporal context in hierarchically structured events.
Overall , these findings highlight that richer information about cognitive failures may be revealed through the investigation of specific factors of cognitive failures.
Overall , these findings may indicate there are limited and mixed associations between stress reactivity and telomere length across physiological systems.
Overall , these findings suggest that adults with DS may benefit from additional support in terms of their social and conceptual abilities as they age.
Overall , these findings suggest that age differentially affects neural processing related to cognitive control during semantic categorization.
Overall , these findings suggest that verbal and visuo-spatial components of WM underpin the processing of environmental information in both young and older adults.
Overall , these findings yield a mixed picture of gender-differentiated vulnerabilities balanced by proactive adaptation and maintenance of social and dyadic assets.
Overall , these genomic knockout results strengthen the pursuit of targeting tumor cell pH regulation as an effective anti-cancer strategy.
Overall , the semantic judgment task in competing speech elucidated the effect of a poor listening environment on the higher order processing of words.
Overall , these pro-inflammatory reactions promote early scar formation associated with tissue fibrosis and reduce functional recovery.
Overall , these properties of action together with recent clinical findings make resveratrol a candidate for the treatment of hyperandrogenic disorders such as PCOS.
Overall , these results demonstrate interactions in the perception of facial age and gender , and support dissociable neuronal coding of male and female faces.
Overall , these results seem to suggest that different cognitive processes underlie the performance on naturalistic and on laboratory time-based tasks.
Overall , these results suggest that sulforaphane induces mitotic arrest and apoptosis of @number@ cells via a ROS-dependent pathway.
Overall , these studies demonstrate the potential role of mast cells in disease progression.
Overall , the study demonstrated significant benefits of MA use in the inhibition of hyperpigmentation caused by UV irradiation.
Overall , the study quality was moderate.
Overall the transcript-level changes indicative of undue inflammatory and stress responses in these older adults were not mirrored in young subjects.
Overall , the UPSA-M appears to be a promising mobile tool to assess functional capacity.
Overall , the use of the present normative data by clinicians will improve their accuracy in detecting cognitive impairment in older adults from Québec.
Overall , this article integrates the concept of compensation into the current model of disability and proposes a framework for identifying and interpreting compensatory behavior.
Overall , this pilot study provided evidence of the validity of the ABC-6 in older adults with diabetes.
Overall , this study does not clearly support the hypothesis that shift-work history in midlife has long-term effects on cognition in older adults.
Overall , this study found agreement in the pains of long-term imprisonment , regardless of the exact length or type of sentence.
Overall , this study provides informative response relationships in AKT-pathway interception that can help refining predictive models in BCR-pathway inhibition in CLL.
Overall , this study provides insight into the function and evolution of both fish and mammalian β-adrenergic receptors.
Overall , this study underscores that intravenously transplanted hASC may have therapeutic potential for PD by recovering mitochondrial functions.
Overall , this work supports cerebrovascular dysfunction as a fundamental underlying process in AD pathology.
Overall , TMT performance was culture-sensitive , whereas BTA performance was not.
Overall , toxic side effects of HAART may both resemble and promote events of aging and are worthy of mechanistic studies.
Overall , unresolved losses and / or mismanagement of life's stresses were found to be the most significant predictors of late-life problematic gambling.
Overall , VCE was superior to CT-enteroclysis ( @percent@ vs @percent@ ; P < .001 ) , in particular when flat lesions were found.
Overall , visual acuity and straylight are rather independent aspects of quality of vision.
Overall , wage differences are largely explained by job quality.
Overall , we elucidated the inhibitory effect of @number@'-THIF on sUV-induced MMPs and suggest PKCα as its direct molecular target.
Overall , we found high acceptance of ASA24 among these diverse samples.
Overall we found little evidence for correlates of change in perceived control , with only the loneliness-control association becoming slightly weaker over time.
Overall , we found no correlation between FoxP3 ( + ) Treg in the pancreatic lymph nodes and the inflammatory scores of individual NOD mice.
Overall , we found that both regionally and across participants , ReHo strongly correlated with CMRGlu in healthy young and older adults.
Overall , we found very limited support for age-differential associations.
Overall , we genetically characterized @percent@ sporadic ALS patients.
Overall , we have characterized previously unrecognized age-dependent expression patterns of plasma purine-metabolizing enzymes that result in elevated plasma concentrations of anti-inflammatory adenosine in newborns.
Overall , we present integrative RNA , DNA , and protein evidence implicating TREML4 in coronary artery calcification.
Overall , we strongly believe that caloric restriction could reduce morbidity and mortality of cardiovascular events in humans.
Overall , we suggest that postmenopausal estrogen deficiency sustains the development of \ "inflamm-aging \ ".
Overall , when compared to literature data for African and Caucasoid subjects , several differences were found , pointing to the necessity of ethnic-specific data.
Overall , women had higher mean temperatures ( @number@ ± @number@.2°F ) than men ( @number@ ± @number@.1°F ; p < @number@ ) .
Overall , women were weaker ( P < @number@ ) .
Overall , wound closure , reepithelialization , and granulation tissue fill were delayed or decreased with aging across different strains of mice and rats.
Overall , younger and older drivers showed comparable driving performance ( lane keeping ) .
Overall , γ-PGA improved chondrogenic differentiation of MSCs , increasing ECM production earlier in culture.
Over a mean follow-up of @number@ months , @number@ participants ( @percent@ ) fell.
Over a mean follow-up of @number@ years , @percent@ of patients survived @number@ year.
Over a mean @number@.8±2.0 years of follow-up , there were @number@ incident adverse CVD events.
Over a median follow-up of @number@ years , @number@ participants developed MCR.
Over a median of @number@ years , we found @number@ strokes.
Over an 18-month implementation period , intervention facilities were instructed to offer the Advance Care Planning Video Program to all patients.
Over an 8-week period a moderate intensity inspiratory muscle training protocol was followed in the TG , while CG followed a sham protocol.
Over an average follow-up of @number@ years , @number@ cases of dementia were diagnosed.
Over a relatively short treatment period of @number@ weeks , tretinoin gel @percent@ was shown to provide both chemoprevention and reversal of photodamage.
Over a series of @number@ experiments , groups of younger and older adults performed recall and recognition tests successively on the same lists of words.
Over a six-week training and supplementation period , MPP use was not associated with improvements in performance or body composition.
Over a typical disease course of 5-10 years , family caregivers provide the majority of the day-to-day hands-on on care for persons with dementia.
Overcash et al. proposed an abbreviated form of CGA using a reduced number of items of ADL , IADL , MMSE and GDS.
Overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors ( EGFR-TKIs ) is an emerging issue in lung cancer treatment.
Overcoming barriers to integrating health promotion and prevention in practice could help improve population health and wellbeing.
Overcoming negative stereotypes of aging through change at the societal and individual level may help to promote more successful aging.
Over decades of investigation , claims have been made that the paradigm produces the most robust demonstration that aging is malleable.
Overdenture as a treatment modality for both partially and fully edentulous patients is costeffective and less expensive.
Overdiagnosis of CKD in older persons is concerning.
Overestimation of physical capabilities can be an additional explanation of the high risk of falls in this population.
Overexposure to UVB will induce severe DNA damages in epidermal cells and cause most cytotoxic symptoms.
Over-expressed LOC100129148 favored , but silenced LOC100129148 hampered cell proliferation in NPC cells.
Over-expressed p16 resulted in early replicative senescence in glucose-restricted cells suggesting a crucial role of p16 regulation in GR-induced cellular lifespan extension.
Overexpressing miR-495 arrested cell cycle in S phase and promoted cell apoptosis.
Overexpressing the circRNA 100269 plasmid inhibited cell proliferation ( p < 0.05 ) .
Overexpression Nrf2 in combination with either p120 or p65 diminished or failed to further increase the GCLC- and GLCM-EpRE luciferase activity.
Overexpression of Adamts1 in macrophages in vivo is sufficient to increase satellite cell activation and improve muscle regeneration in young mice.
Overexpression of APP / BACE-1 resulted in the progressive and measurable defects in morphology of eyes and locomotion.
Overexpression of CHIP prevents nuclear translocation of hTERT and promotes hTERT degradation in the cytoplasm , thereby inhibiting telomerase activity.
Overexpression of circCOL3A1-859267 inhibited UVA-induced decrease of type I collagen expression and silencing of it reduced type I collagen intensity.
Overexpression of dMRP4 , on the other hand , is sufficient to increase oxidative stress resistance and extend lifespan.
Overexpression of functionally intact EphA2 in old hCPCs corrected the defects in endocytosis and downstream signaling , enhancing cell motility.
Overexpression of genes on chromosome-21 is thought to underlie the pathogenesis of the major phenotypic features of DS , such as premature aging.
Over-expression of GJA3 gene restrained the lens epithelial cells apoptosis induced by H2O2.
Over-expression of GLaz is able to reduce p62 and ubiquitinated proteins levels when rapamycin-dependent and SCA1-dependent inductions of autophagy are combined.
Overexpression of human HSJ1a ( hHSJ1a ) in vivo in motor neurons of SOD1 ( G93A ) transgenic mice ameliorated disease.
Overexpression of miR-107 in K562 and KCL-22 chronic myeloid leukemia cells promotes erythroid differentiation , while having no effect on cell proliferation.
Over-expression of miR-127 or depletion of BCL6 inhibits breast cancer cell proliferation.
Overexpression of miR-181 in SH-SY5Y cells significantly decreased c-Fos and SIRT-1 , strongly suggesting that miR-181 directly regulates the expression of these two proteins.
Overexpression of miR-22 in young EPCs induced cell senescence , decreased proliferation and migration , and impaired angiogenesis in vitro.
Over-expression of MRG15 in HeLa cells activated a cdc2 promoter-reporter construct in a dose-dependent manner , whereas knockdown of MRG15 resulted in decreased promoter activity.
Overexpression of mTOR was observed in differentiated VSMCs.
Overexpression of NICD and HIF-1α in cultured human neural cells enhanced cell death under ischemia-like conditions , and a HIF-1α inhibitor rescued the cells.
Overexpression of p190 mRNA associated with poor disease-free survival.
Over-expression of Pin1 can promote oncogenesis through a number of signaling pathways.
Overexpression of RCAN1 decreased the number of branching points that sprouted from intersomitic vessels during X. laevis angiogenesis.
Overexpression of SIRT1 or treatment with a novel activator is sufficient to improve metabolism , supporting the idea that resveratrol could act through this pathway.
Overexpression of Skp2 increased resistance of LNCaP cells to chemotherapy drugs.
Overexpression of Skp2 , or siRNA knockdown of p21Cip1 , p27Kip1 , or p53 blocked suppressive effect of CAPE treatment.
Overexpression of SMP30 prevented oxidative stress insults.
Over-expression of SNAI2 in DU145 cells substantiated its ability to regulate metastasis-suppressor , NED and pluripotency genes.
Overexpression of SOAT1 reduced the 7KCh-induced inflammatory response and provided some protection from cell death.
Overexpression of SOD1 was not associated with any volume alteration.
Overexpression of the de-ubiquitinating enzyme UCH-L1 leads to inclusion formation in response to proteasome impairment.
Overexpression of the Klotho gene extends lifespan and defective Klotho results in rapid aging and early death.
Overexpression of the palmitoylating enzymes DHHC7 and DHHC21 that increase palAPP levels and Aβ release , also increased APP dimerization in cells.
Over-expression of these miRNAs increases the rate of apoptosis , accompanied by a decline in Bcl-2 expression in miRNA-transfected mouse and human cell lines.
Overexpression of the wild type Spp1 , but not Spp1 lacking a Cd44 binding domain , rescued cell ability to form spheres.
Over-expression of wild-type hUbb , but not hUbb ( @number@ ) , was toxic during fly development.
Overexpression of ZNF216 protein sensitizes @number@ cell line to TNF-α induced apoptosis.
Overexpression or knockdown of Mbnl1 in hepatoma and embryonic kidney cells altered the levels of exon @number@ inclusion.
Overfitting eHEALS items ( 2-5 ) displayed a similar degree of information for respondents at similar points on the latent continuum.
Overflow was concurrently recorded in the non-task hand.
Overflow was exacerbated when older adults were unaware of it , and was reduced once they were informed.
Overground CWS was assessed using the 10-meter walk test with and without visual stepping targets.
Over half of frail persons had a fall in the previous year.
Over half of PVL positive S. aureus infections originated in patients based in the community.
Over half of the heritability is explained by two major loci , thus AMD is considered the most well genetically defined of the complex disorders.
Overlapped nodes between communities were defined by assuming that nodes ( brain regions ) can belong to more than one community.
Overlapping cell procedure and midpoint techniques were applied to develop the normative data.
Overlapping target gene signatures were observed in squamous cancer subsets and in inflamed skin of transgenic mice overexpressing ΔNp63α.
Overlaps between frailty , comorbidity and disability were assessed using proportions.
Overlaps were only observed in the conjunction of dorsolateral prefrontal cortex ( DLPFC ) gray matter reduction and functional hyperactivation but not hypoactivation.
Over last few decades , the burden of smoking-related diseases has increased in older adults.
Overloading produces collagen network damage and proteoglycan loss , leading to irreversible cartilage destruction because of lack of regenerative capacity.
Overlooking certain psychosocial aspects of living in the very old may pose a risk of both underdiagnosis and overdiagnosis in the spectrum of depressive disorders.
Overnight fasting blood samples were collected from all subjects.
Overnight-fasting blood samples were obtained to measure biochemistry indicators.
Over @number@ billion dollars per year are spent on care for AMD patients in the US.
Over @number@ children are in foster care in the United States , and more than @number@ of them are waiting to be adopted.
Over @number@ factors are associated with falls risk , making identification and targeting of key factors to prevent falls problematic.
Over @number@ gene mutations are known to cause hypertrophic cardiomyopathy ( HCM ) .
Over @number@ months @number@ HIV-positive and @number@ HIV-negative men were recruited.
Over @number@ months , @number@ residents ( @percent@ ) died.
Over @number@ months of calendar pages were returned by @number@ women , who reported @number@ falls.
Over @number@ months of observation , @number@ participants enrolled ( mean age @number@ ) .
Over @number@ months , weight loss was ∼2-3 times greater in both PN than WN groups.
Over @number@ mutations in superoxide dismutase-1 ( SOD1 ) cause familial amyotrophic lateral sclerosis ( ALS ) , a lethal motor neuron disease.
Over @number@ mutations in the LMNA gene , encoding A-type lamins , are associated with @number@ human degenerative disorders and premature aging syndromes.
Over @number@ papers were reviewed and @number@ were included.
Over @number@ per cent of respondents were not born in Canada and did not speak English as their first language.
Over @number@ years ago , Francois Jacob proposed that levels of ' integrons ' explain how biological systems are constructed.
Over @number@ years ago , we introduced the concept of glycolytic inhibition as a strategy for developing mimetics of CR.
Over @number@ years ago , we proposed that glycolytic inhibition could be an effective strategy for developing CRM.
Over @number@ years of follow-up , @number@ new cases of depression were recorded.
Over @number@ years of follow-up , @number@ participants died.
Over @number@ years of follow-up , @number@ ( @percent@ ) participants developed dementia.
Overnutrition and sedentary lifestyle result in overweight or obesity defined as abnormal or excessive fat accumulation that may impair health.
Over one-fifth of the total healthcare costs of SHS exposure in rural China were paid by health insurance.
Over one-quarter of the sample ( n = @number@ ) had a depression score consistent with significant symptoms of depression.
Over one-third ( 34·0% ) had at least one type of drug interaction.
Over one third ( @percent@ ) fell in the last @number@ days and @percent@ fell in the last year.
Over @percent@ of adults with HIV exhibit some form of HIV-associated neurocognitive disorder , ranging from mild asymptomatic neurocognitive impairment to HIV-associated dementia.
Over @percent@ of geriatricians had active certification , @percent@ were females and the average age was @number@ years.
Over @percent@ of new cancers and @percent@ of cancer deaths occur in individuals aged @number@ years or older.
Over @percent@ of patients had no viral load measured in a given interval or the past @number@ years.
Over @percent@ of sites did not specify the number or duration of treatments.
Over @percent@ of students had a strong interest in a surgical career at entry , dropping to @percent@ at exit.
Over @percent@ of survey respondents judged the competencies as comprehensive and developmentally appropriate ( survey response rate = @percent@ , 71 / 98 ) .
Over @percent@ of the athletes were hypohydrated ( urine specific gravity [ USG ] ≥1.020 mg·dl ) based on their first morning urine sample.
Over @percent@ of those exposed to polypharmacy were exposed for @number@ or more days of the year.
Over @percent@ of urologists are older than @number@ years and @percent@ are older than @number@ years , suggesting an aging urology workforce.
Over @percent@ were collected outdoors through human landing catches and Prokopack aspiration.
Overproduction of oxidant compounds can induce an inflammatory response , since oxidants are inflammation effectors.
Overproduction of ROS or insufficient defense mechanisms leads to a dangerous disbalance in the organism.
Over recent decades , many of the molecular and cellular correlates to estrogen's beneficial effect on normal skin homeostasis and wound healing have been reported.
Over-represented in the Ashkenazi Jewish population , these mutations are transmitted in an autosomal dominant manner with age-dependent reduced penetrance.
Over six years , fallers had a notable chronic lowered score in both HRQoL and LS , compared to non-fallers.
Over subsequent years , frail respondents were more likely to be hospitalized , report more loss of independence , and experience higher mortality rates.
Over the 12-month follow-up period , @number@ ADRs occurred in @number@ participants , including @number@ ADRs considered preventable and @number@ considered severe.
Over the 15-year follow-up , there were @number@ @number@ and eighty-four incident cases of any , early and late AMD , respectively.
Over the 2012-2050 period , the present value of cost savings is projected to amount to C $ 13.1 billion in @number@ dollars.
Over the 2012-22 period , national health spending is projected to grow at an average annual rate of @number@ percent.
Over the 9-year follow-up , @number@ ( @percent@ ) subjects died.
Over the centuries it has been used as an indicator of social status , gender , and level of authority.
Over the coming years , the incidence of age-related chronic diseases such as cancer is expected to continue to increase.
Over the course of most common neurodegenerative diseases the amygdala accumulates pathologically misfolded proteins.
Over the course of @number@ months , the sitting ability of infants drastically improves.
Over the course of one year , this can result in a significant increase in body mass.
Over the course of the experiment , all list positions were tested an equal number of times.
Over the course of the past eighteen years , health system organization was subjected to variations and significant tensions.
Over the course of the study , @number@ participants developed dementia.
Over the last century , Inuit have experienced rapid social changes that have greatly impacted their way of life , health , and intergenerational traditions.
Over the last decade , hydrogen sulfide ( H PICH is a DNA translocase required for the maintenance of chromosome stability in human cells.
Over the last decade it has become evident that epigenetic markers can be of substantial forensic significance.
Over the last decade , nanoparticle-mediated drug delivery represents one promising strategy to successfully increase the CNS penetration of several therapeutic moieties.
Over the last decades , testosterone replacement therapy for middle-aged and older men has been gaining increasing and widespread attention and popularity.
Over the last decade there has been increasing interest in the idea that epithelial-mesenchymal transition ( EMT ) may be active in COPD.
Over the last few decades , the understanding of the renin-angiotensin system ( RAS ) has advanced dramatically.
Over the last four decades , animal and cell culture studies have shown that sex steroids can have protective effects on the ageing brain.
Over the last @number@ decades human immunodeficiency virus ( HIV ) infection has become a chronic disease requiring long-term management.
Over the last @number@ years , developments in injectable dermal fillers have led to a revolution in facial soft-tissue augmentation.
Over the last @number@ years , lasers applications in dermatology have become more specific and often irreplaceable.
Over the last @number@ years , major advances in the provision of services for frail older people in Australasia have taken place.
Over the last @number@ years , the diagnosis small fiber neuropathy ( SFN ) has gained recognition worldwide.
Over the last @number@ years the number of prescriptions that have been compounded by pharmacists has increased dramatically.
Over the last several decades , neuroimaging research has identified age-related neural changes that occur during cognitive tasks.
Over the last several decades , the understanding of the brain's role in the development of hypertension has dramatically increased.
Over the last two centuries , there has been a significant increase in average lifespan expectancy in the developed world.
Over the last two decades , consequences of HIV infection of the CNS on disease severity and clinical neuropsychiatric manifestations have changed.
Over the last two decades , intensive research has proven this molecule , as well as its metabolites , to possess substantial antioxidant activity.
Over the last two decades , research has assessed the relationship between neighborhood socioeconomic factors and individual health.
Over the last years medicine has progressed very rapidly.
Over the median @number@.7-year follow-up period , @number@ participants developed dementia , including @number@ cases of AD.
Over the median @number@ years of follow-up , @number@ participants developed T2D.
Over the next fifty years , the number of older adults is set to reach record levels.
Over the @number@ year follow-up , TC levels declined in those with MCI and AD , but remained stable in those who remained healthy.
Over the past decade , facial cosmetic procedures have become more commonplace in dentistry and oral and maxillofacial surgery.
Over the past decades cardiovascular disease management has been substantially improved by the increasing introduction of medical devices as prosthetic valves.
Over the past decade , the associations among obesity , adipokines and cancer have been increasingly recognized.
Over the past decade there have been advances in the application of these principles to brain-injured laboratory animals.
Over the past few decades , age-associated degeneration of the neuromuscular junction ( NMJ ) and its components have been well documented.
Over the past few decades , the longest extension in life expectancy in the world has been observed in Japan.
Over the past few years it has become clear that mitochondria are not merely the powerhouses of cells.
Over the past few years , research on Alzheimer's and Parkinson's diseases has made tremendous progress.
Over the past few years , studies in Drosophila have significantly contributed to this new frontier of cancer research.
Over the past five decades , the organization of women's lives has changed dramatically.
Over the past @number@ decades , there has been considerable progress in the assessment of function and disability in older persons.
Over the past @number@ years , a total of @number@ ACS patients over @number@ years old were treated.
Over the past @number@ years , suitable models for stroke in aged rats have been established.
Over the past @number@ years , the prevalence of Helicobacter pylori infection has fallen as standards of living improved.
Over the past @number@ years , WNV has become established throughout the USA and has spread into Canada , Mexico and the Caribbean.
Over the past several decades , the world and most countries have undergone unprecedented demographic change.
Over the past several years we have shown that microglia play a dichotomous role in AD.
Over the past three decades , bacteraemic OAI increased in association with aging and use of orthopaedic devices.
Over the past three decades , several human health disorders have been related to GI.
Over the past three decades , the prevalence of diabetes has increased four-fold.
Over the past three decades , the United Nations ( UN ) has slowly devoted increasing attention to global ageing.
Over the past two decades it became evident that the immune system plays a central role in modulating learning , memory and neural plasticity.
Over the past two decades , there has been an increase in testing of testosterone levels and the use of TST.
Over the past years , increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes ' entity.
Over the past years , many distinct , yet overlapping mechanisms have been proposed to explain organismal aging.
Over the years , a lot of approaches have been suggested for the prediction of drug clearance or dose in paediatrics.
Over the years , a number of anti-aging medicines of natural and synthetic origin have been introduced.
Over the years , many questions regarding vertical allometry have been raised.
Over the years , numerous theories have evolved as treatment modalities.
Over the years , the associations between these concepts have been investigated in different populations.
Over the years , various factors are suggested which may contribute to or disable activity provision in dementia care homes.
Over the years , various materials have evolved to correct soft tissue defects , including a number of tissues and polymers.
Over this 8-year period , the age-standardized incidence of hip fracture decreased by @percent@ among women and @percent@ among men.
Over this same period , almost @number@ million individuals developed incident CIND.
Over time , a number of theories have been proposed in an attempt to explain the processes leading to the development of delirium.
Over time , breast cancer survivors had significantly higher tumor necrosis factor-α and IL-6 compared with the control group.
Over time , excessive energy demands on the system can lead to premature aging and diseases.
Overtime exits due to death become progressively more important ; @percent@ disabled at baseline are dead by Wave @number@ compared to @percent@ for nondisabled.
Over time , homogentisic acid polymerizes and deposits in collagenous tissues , leading to ochronosis.
Over time , Mike reclaims lost expertise and takes on new complex cognitive challenges.
Over time , participants in the RMS group showed greater improvements in activation , self-care , and QOL compared with their counterparts.
Over time pelvic floor ligaments and vaginal tissues will differentiate and acquire different mechanical behavior , as seen within the literature in older cadavers.
Over time , the face undergoes changes in skin and subcutaneous tissues evidenced by rhytides and thinning.
Over time , the long-lived proteins that are present throughout the human body deteriorate.
Over time , the prevalence of this type of living arrangement declined , as incomes increased.
Overtriage rates have remained slightly above or within an acceptable range , suggesting that gains in triage accuracy have not unduly overburdened trauma centers.
Overt tau pathology in the aged mice was accompanied by spatial memory deficits.
Over two-third elderly were having somatic ( @percent@ ) and depression ( @percent@ ) related symptoms of anger - hostility , cognition and anxiety.
OVERVIEW : Current interventions for age-related cognitive decline are reviewed in terms of stimulation- and compensation-focused interventions.
Overweight and obese women had higher risks of incident disease and mobility disability.
Overweight and obese women who lost weight decreased their risk of hyperglycaemia to a level comparable to weight-stable normalweight women.
Overweight and obese women with stable weight presented a two-fold increased risk of hyperglycaemia compared to normalweight weight-stable women.
Overweight and obesity are associated to the occurrence of the metabolic syndrome and to adipose tissue dysfunction.
Overweight and obesity due to excess adipose tissue , are cornerstones of vascular risk and increase risk for late-onset dementia.
Overweight and obesity increased with age ( p < 0.01 ) , even after adjusting for workplace characteristics.
Overweight and obesity was classified according to WHO classification.
Overweight at the age of @number@ years.
Overweight early pubertal girls have significant blunting of sleep-related LH production , which is the first hormonal change of puberty.
Overweight / obese late-life BMI was associated with increased posthemorrhagic stroke mortality.
Overweight was estimated using measured weight and height.
Ov / ob obesity prevalence was significantly lower in @number@ compared with @number@ in children aged @date@ years.
Ov / Ob prevalence increased in most subgroups studied until @number@
Ov / ob prevalence was significantly higher in @number@ compared with @number@ in girls aged 12-16 years and in boys aged 8-16 years.
Ovoderm is an oral supplement obtained from eggshells that contains naturally occurring collagen and glycosaminoglycans , such as hyaluronic acid.
Owing to advances in modern medicine , life expectancies are lengthening and leading to an increase in the population of older individuals.
Owing to a recent trend for delayed paternity , the genomic integrity of spermatozoa of older men has become a focus of increased interest.
Owing to equal and increased opportunities for education and employment , today's trend in Japanese marriages is characterized by late and less frequent marriage.
Owing to its great efficacy and lack of adverse effects , H2 has potential for clinical applications for many diseases.
Owing to retirement , wealth may be a better marker of financial resources among older adults.
Owing to the increasing growth in this segment of our population , its burden on health care resources will increase in the future.
Owing to their specific risk profiles , some AF populations may have increased risks of both thromboembolic and bleeding events.
Owing to the lack of treatment options , there is a need for novel treatments such as stem cell therapy.
Owing to these new insights , a reevaluation of the sensitivity of aged skin has to be initiated , especially with regard to occupational dermatology.
Owing to this high prevalence in the aging population , dementia will impose significant economic burdens to Korean society.
Owing to treatment-related toxicities , there is no standard chemotherapy for the elderly patients , especially those aged @number@ years or older.
Owner-answered questions about activity and signs of pain were compared between the @number@ groups to define items relating to chronic DJD pain.
Owner-perceived severity correlated significantly with QoL1 and QoL2 ( P = @number@ and P = @number@ respectively ) .
Owner personality was assessed using the NEO-FFI.
Owners and veterinarians selected a 5-point descriptive instrument design over 11-point or visual analogue scale formats.
Owner sex , age or educational level did not influence QoL scores.
OW-Untrained then underwent a @number@ month aerobic and resistance exercise programme and repeated testing ( OW-Trained ) .
Oxaliplatin-based chemotherapy exerts its effects through generating DNA damage.
Oxidant-antioxidant imbalance is recognized as one of the significant factors in COPD pathogenesis.
Oxidant formation , detected by 3-nitrotyrosine staining and dihydroethidine-based fluorescence microtopography , was increased in the aged GPx-1 ( - / - ) mice.
Oxidation often occurs at multiple sites , leading to mixtures of oxidation isomers that differ only by the site of modification.
Oxidation of unsaturated lipids generates reactive aldehydes that accumulate in tissues during inflammation , ischemia , or aging.
OXIDATION STRESS : Oxidation stress and its form caused by ultraviolet light- photo-oxidative stress are considered to be crucial in the etiopathogenesis of cataract.
Oxidative and antioxidative processes are associated with electron transfer influencing the redox state of cells and the organism.
Oxidative capacity of muscle fibres was assessed with quantitative histochemistry for succinate dehydrogenase ( SDH ) activity.
Oxidative damage contributes to human diseases of aging including diabetes , cancer , and cardiovascular disorders.
Oxidative damage is a major cause or consequence of cortical and nuclear cataracts , the most common types of age-related cataracts.
Oxidative damage is considered to be the primary cause of several aging associated disease pathologies.
Oxidative damage , like other specific damage types viewed in isolation or in combination , does not represent the cause of aging.
Oxidative damage may arise from endogenous and exogenous sources and may target nuclear and mitochondrial DNA as well as RNA and proteins.
Oxidative damages are linked to several aging-related diseases and are among the chemical pathways determining protein degradation.
Oxidative damage was assessed by immunohistochemistry to ( 8-OHdG ) and Western blotting for malondialdehyde.
Oxidative DNA damage and a DNA damage response are features of WML pathogenesis and suggest candidate mechanisms for glial dysfunction.
Oxidative DNA damage cannot serve as an universal early marker of T2DM.
Oxidative DNA damage is unable to fully explain the reduced proliferation of human cardiomyocytes.
Oxidative DNA damage seems to play a crucial role in chronic , aging-related diseases and it is considered an important and probably carcinogenic factor.
Oxidative exposure of cells occurs naturally and may be associated with cellular damage and dysfunction.
Oxidatively modified proteins nearly always have altered structure and function.
Oxidative modifications in proteins have been traditionally considered as hallmarks of damage by oxidative stress and aging.
Oxidative posttranslational modification of cysteine residues to regulate protein function , termed S-nitrosylation , constitutes a major form of redox-based signaling by NO.
Oxidative signaling and oxidative stress contribute to aging , cancer and diseases resulting from lung fibrosis.
Oxidative stress also plays important roles in the pathogenesis of many diseases , including aging , degenerative disease , and cancer.
Oxidative stress and chronic inflammation increase as aging which relate with sarcopenia.
Oxidative stress and DNA damage-signaling gene expression were analyzed using commercial PCR-based microarrays.
Oxidative stress and fibrosis emerge in advanced age.
Oxidative stress and inflammation appear to be the two primary pathological mechanisms of ageing-related endothelial dysfunction even in the absence of clinical disease.
Oxidative stress and inflammation are constant features of many chronic diseases and complications , and have been linked to carcinogenesis.
Oxidative stress and inflammation are key features in the initiation , progression , and clinical manifestations of smooth muscle disorders.
Oxidative stress and inflammation are supposed to be the key players of several acute and chronic diseases , and also for progressive aging process.
Oxidative stress and inflammation have both physiological and potentially pathological roles in RPE degeneration.
Oxidative stress and inflammation may be involved in the etiology of age-related cataract.
Oxidative stress and lipophilic anti-oxidative capacities in GBS patients have not been fully explored.
Oxidative stress and mitochondrial dysfunction are highlighted as a central feature of brain degenerative diseases.
Oxidative stress and nutritional deficiency may influence this process.
Oxidative stress and recently inflammation , have been pointed out as the leading causes of brain aging.
Oxidative stress and synapse dysfunction are the major neurodegenerative damage correlated to cognitive impairment in Alzheimer's disease ( AD ) .
Oxidative stress appears to be involved in the pathogenesis of HGPS , although the mechanistic role of progerin remains elusive.
Oxidative stress , a risk factor in the pathophysiology of Alzheimer's disease , is intimately associated with aging.
Oxidative stress augmented the defects caused by Stn1 knockdown leading to almost immediate cessation of cell proliferation.
Oxidative stress by these hazardous factors accelerates skin aging and induces skin inflammation and carcinogenesis.
Oxidative stress , capable of eliciting damage to various biomolecules including DNA , is a recognized component of diabetes mellitus and its complications.
Oxidative stress , considered as a major culprit in brain aging , triggers cognitive and memory impairment.
Oxidative stress damages DNA and introduces mutations into oncogenes or tumor suppressor genes , thus contributing to cancer development.
Oxidative stress did not account for nutrient toxicity on serum-starved cells.
Oxidative stress due to the over-production of reactive oxygen species ( ROS ) is associated with human skin aging.
Oxidative stress , endothelial biomarkers and leukocyte adhesion molecule levels were also evaluated.
Oxidative stresses also affect intracellular Ca ( 2 + ) regulation and impair embryo development after fertilization.
Oxidative stress has also been shown to promote telomere attrition.
Oxidative stress has been advanced as one of the major causes of damage to DNA and other macromolecules.
Oxidative stress has been associated with normal aging and Alzheimer's disease ( AD ) .
Oxidative stress has been implicated in aging and many human diseases , notably neurodegenerative disorders and various cancers.
Oxidative stress has been recognized as a contributing factor in aging and in the progression of multiple neurodegenerative diseases including AD.
Oxidative stress has serious damaging effects on the cellular contents : DNA , RNA , cellular proteins , and cellular organelles.
Oxidative stress imposed by reactive oxygen species plays a crucial role in pathophysiology of inflammatory diseases.
Oxidative stress in brain is emerging as a potential causal factor in aging and age-related neurodegenerative disorders.
Oxidative stress induces Bak expression in primary cochlear cells , and Bak deficiency prevents apoptotic cell death.
Oxidative stress influences mitochondrial dysfunction or induces apoptosis.
Oxidative stress inhibits the production of collagen , the most abundant protein in skin , and thus contributes to connective tissue aging.
Oxidative stress in mitochondria is believed to promote aging.
Oxidative stress is a hallmark of chronic non-communicable diseases such as arterial hypertension , coronary artery disease , diabetes , and chronic renal disease.
Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions.
Oxidative stress is also implicated in AD pathology from an early stage.
Oxidative stress is also implicated in the activation of signal transduction pathways , such as mitogen-activated protein kinase ( MAPK ) .
Oxidative stress is believed to greatly contribute to the pathogenesis of various diseases , including neurodegeneration.
Oxidative stress is believed to play a central role in aging and age-associated diseases.
Oxidative stress is both the cause and consequence of impaired functional homeostasis characterizing human aging.
Oxidative stress is caused by an imbalance between the antioxidant and the reactive oxygen species , which results in damage to cells or tissues.
Oxidative stress is caused by damaging factors like noise , infection , and other systemic factors.
Oxidative stress is commonly implicated in aging and neurodegenerative conditions such as Parkinson's disease ( PD ) .
Oxidative stress is considered a major risk factor in aging , inflammation , cancer , atherosclerosis , and diabetes mellitus.
Oxidative stress is increased in frail older people , and may lead to accelerated aging and higher incidence of oxidative diseases such as CVD.
Oxidative stress is involved in many age-associated diseases , as well as in the aging process itself.
Oxidative stress is known to be involved in the pathogenesis of this condition.
Oxidative stress is known to play a relevant role in Down syndrome ( DS ) and its effects are documented from embryonic life.
Oxidative stress is not necessarily an un-wanted situation , since its consequences may be beneficial for many physiological reactions in cells.
Oxidative stress is one of the major causes of aging considered at both the cellular and organismal levels.
Oxidative stress is thought to be one of the main mediators of neuronal damage in human neurodegenerative disease.
Oxidative stress is thought to play a significant role in the development and progression of neurodegenerative diseases.
Oxidative stress is widely thought to underpin many aging processes.
Oxidative stress levels altered Band @number@ protein and mediated caspase-3 activation in erythrocyte from the aged group although it was not extended to hypoxic individuals.
Oxidative stress markers ( malondialdehyde-MDA and superoxide dismutase-SOD ) were determined and DNA damage was assayed using Alkaline Comet Assay.
Oxidative stress may instigate or accelerate the development of vascular disease , and oxidative stress markers are elevated in AD.
Oxidative stress occurs when the formation of oxidants exceeds the ability of antioxidant systems to remove the ROS in organisms.
Oxidative stress occurs when there is an excess of pro-oxidants over antioxidants and it has been implicated in several diseases.
Oxidative stress ( OS ) and damages due to excessive reactive oxygen species ( ROS ) are common causes of injuries to cells and organisms.
Oxidative stress ( OS ) is the main cause leading to brain aging and related diseases.
Oxidative stress ( OxS ) and inflammation are physiopathological mechanisms related to diabetes and aging.
Oxidative stress parameters were investigated in a subsample.
Oxidative stress plays a crucial role in the development of the aging process and age dependent diseases.
Oxidative stress plays a key role in late onset diseases including cancer and neurodegenerative diseases such as Huntington disease.
Oxidative stress plays a major role in the pathophysiology of chronic inflammatory disease and it has also been linked to accelerated telomere shortening.
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in Parkinson's disease ( PD ) .
Oxidative stress promotes both the transcriptional activity and protein stability of FoxOs.
Oxidative stress reflects an imbalance between antioxidants and pro-oxidants.
Oxidative stress was evaluated by measuring the level of urinary ( 8-OHdG ) .
Oxidative stress was measured using serum protein carbonyl concentrations.
Oxidative stress with its associated burden might alter the disease process.
Oxidized cytoplasmic and nuclear proteins are normally degraded by the proteasome , but accumulate with age and disease.
Oxidized hPTEN was reduced by cellular reductants as in human cells.
Oxidized-LDL and sVCAM could determine %Hyper through LMR.
Oxidized LDL ( oxLDL ) and nitric oxide ( NO ) exert contradictory actions within the vascular endothelium microenvironment influencing key events in atherogenesis.
Oxidized LDL was measured also with a method based on antibodies against oxidized Apo-B ( oxLDLprot ) .
Oxidized mitochondrial proteins must be removed rapidly ( by proteolytic degradation ) or they will aggregate , cross-link , and cause toxicity.
Oxidized protein repair is limited to certain oxidation products of the sulfur-containing amino acids cysteine and methionine.
Oxidized proteins were biosynthetically generated in situ by substituting oxidized analogues for parent amino acids.
Oxidized PTEN is converted back to the reduced form by cellular reducing agents , predominantly by the thioredoxin ( Trx ) system.
Oxidized PTEN was reduced when treated with dithiothreitol.
Oxi-inflammatory load could be calculated only in the Newcastle 85 + and the Leiden 85-plus studies.
OXM induced intracellular cAMP production and activated cAMP-response element-binding protein ( CREB ) .
OXN-PR was also associated with significant improvement in daily functioning ( Barthel Index from @number@.3±14.1 to @number@.3±14.3 ; P < 0.01 ) .
OXN-PR was well tolerated ; only one patient ( @percent@ ) prematurely withdrew from treatment , due to drowsiness.
OxPAPC restored insulin secretion in islets incubated with @number@ ng / ml eHSP72.
OXPHOS is dependent on the coordinated expression and interaction of genes encoded in the nuclear and mitochondrial genomes.
Oxygen consumption and heart rate were measured as variables of response to the physical workloads.
Oxygen consumption ( VO2 ) and energy expenditure for six gardening tasks were measured via indirect calorimetery using the portable Oxycon mobile device.
Oxygen metabolism and circulatory physiology are measurable indices of ocular health that can detect variations of physiology and early disease.
Oxygen uptake ( V˙O2 ) was continuously measured during the test , and afterwards , VT was visually detected.
Oxyntomodulin ( OXM ) is a proglucagon-derived peptide that co-activates the GLP-1 receptor ( GLP-1R ) and the glucagon receptor ( GCGR ) .
Oxyphil cell transformation of epithelial cells due to the accumulation of mitochondria occurs often during cellular aging.
OXY positively correlated with the platelet counts , albumin , and creatinine levels , while negatively correlating with age.
Oxysterols , oxidized derivatives of cholesterol , are known to act as key actors in degenerative disorders such as skin photoaging.
Oxytocin was positively associated with diminished stress among securely attached participant ( event with little suffering : β = 0.35.
P < 0.0001 , and ρ = 0.37 , P < 0.0001 , respectively ) but not with glycemic control or DM duration.
P < 0.0001 , ρ = 0.45.
P < 0.05 was considered the threshold for significance.
P1 latency was shorter in young adults and correlated negatively with task accuracy ( with age partialed out ) .
P2Y12 inhibitors were also more likely associated with traumatic brain injury aOR @number@ ( @percent@ CI @number@ @number@ ) .
P300 amplitude is associated with the attentional system and working memory , with higher amplitudes representing more preserved functions.
P300 ERP amplitude reduction could be an indicator of the progression of illness and chronicity.
P300 latency correlated with neuropsychological test scores and with EEG variables.
P300 latency represents the information processing time ; longer latencies represent slower processing.
P300 latency was significantly shorter , and P300 amplitude was significantly smaller under the @percent@ condition than under the @percent@ condition.
P300 topography was also different as the anterior-to-posterior scalp amplitude gradient was reversed in DLB.
P300 was more delayed and had lower amplitude in DLB compared to AD groups.
P3 cells also presented increased expression and activity of tissue factor ( TF ) , a key initiator of the coagulation cascade.
P407 gels were characterized by critical gelation temperature , rheological measurements and in vitro drug release studies.
P407 gels were loaded with either ALA or dispersions containing ALA cubosomes.
P407 gels were prepared using the cold method.
p53 constitutes an extremely versatile molecule , primarily involved in sensing the variety of cellular stresses.
P53 is a famous cancer suppressor and plays key roles in metabolism.
P53 is an important tumor suppressor that , upon activation , induces growth arrest and cell death.
PA and BIVA were determined from BIA data.
PABPN1 protein accumulation is regulated by the ubiquitin proteasome system , which is highly dysregulated in oculopharyngeal muscular dystrophy.
Pachydermia results in leonine facies , a major cause of cosmetic and functional morbidity in these patients.
Pachydermoperiostosis is a rare syndrome that hinders patients ' quality of life thru its aesthetics manifestations and functional obstacles.
Package inserts were utilized for approval dates , indications , and formulations available.
Package opening tasks have been identified as some of the most challenging that individuals need to perform to access food.
Pack year count was inversely correlated to hTERT scoring in the epidermis ( percentage of cells stained ) and hTERT expression in the dermis.
PA correlates were analyzed using the summary code approach within the socio-ecological model.
PAC was associated with the expression levels of @number@ transcripts in nonagenarian subjects.
PAC was known to be significantly lower in Blacks than Whites.
PA did not affect rates of cognitive or functional decline.
PAD is an important circulatory system disorder similar in prevalence to stroke and coronary heart disease.
PADL scores were strongly associated with formal care costs while IADL scores correlated strongly with informal care costs.
PADL was assessed subjectively by the modified Baecke questionnaire and objectively using a pedometer.
PAD prevalence and incidence did not differ by sex alone.
PAD was defined as an ankle-brachial index ≤0.9.
PAD was defined as having an ABI less than @number@
PA & E attitudes were explored as predictors of self-reported exercise habits.
PAEE was estimated by subtracting resting metabolic rate and the thermic effect of food from total daily energy expenditure estimated by DLW.
PAF-AH genotypes were determined by PCR and restriction fragment length polymorphism analysis.
P. africanum was the plant with the most promising activity and will be subjected to further testing and isolation of the active compound / s.
PAI-1 levels were higher in cognitively normal and nonamnestic multiple domain MCI than in amnestic multiple domain MCI.
PAI- @date@ be a potential biomarker candidate for COPD-specific and extra-pulmonary manifestations.
Pain also contributes to further complications in treatment and care.
Pain and depression warrant detailed considerations when working with older adults on inpatient units when poor sleep is a concern.
Pain and injury in early life may cause long-term changes in somatosensory and pain processing.
Pain and other important risk factors of delirium were often not taken into account.
Pain and patient satisfaction rates were also evaluated.
Pain and severe fatigue were the most common health issues in adult CP.
Pain assessment is central to adequate pain management.
Pain assessment of cognitively intact as well as cognitively impaired residents was conducted using questionnaires , observation , and medical record examination.
Pain assessment was reported between @number@ and @number@ in all treatments ( scale 0-10 ) .
Pain associated to bone metastasis is a major cause of morbidity in cancer patients , especially in elderly.
Pain can be a frequent problem in dementia and may have significant effects on behavior and mood.
Pain catastrophizing was found to predict pain intensity and , although age was a significant moderator , statistical findings were weak.
Pain complaints were reported significantly more frequently by women than men ( P < 0.05 ) .
PA increased weekly exercise and leisure walking relative to control , irrespective of neighborhood compactness.
Pain intensity and functional disability were assessed using numerical pain rate scale and neck disability index , respectively.
Pain intensity and pain interference were measured using the Medical Outcomes Study 36-item Short-Form Survey bodily pain questions.
Pain intensity measured by a point numeric rating scale was statistically significant reduced for p < @number@ by one-fraction regimen compared to other two regimens.
Pain intensity was assessed with a visual analog scale before , during and after the stimulation.
Pain intensity was evaluated with the numeric rating scale ( NRS ) .
Pain is a highly prevalent and clinically important problem in the elderly.
Pain is common in older adults , is frequently experienced as stressful , and is associated with increased morbidity and mortality.
Pain is common in the aging population , particularly among older residents of nursing homes.
Pain is highly prevalent in frail older people who often have multiple co-morbidities and multiple medicines.
Pain is , in general , under-recognized and undertreated in people with dementia and may therefore trigger or exacerbate neuropsychiatric symptoms.
Pain is one of the most frequent reasons for consultations in general practice , presenting either alone or associated with some comorbidity.
Pain items demonstrated remarkable similarity among age cohorts.
Pain levels were comparable between the groups.
Pain levels were not significantly different between Caucasians and African Americans.
Pain management is an ongoing issue in the elderly , and remains underestimated and under-treated in this fragile population.
Pain occurs most often in synovial joints , the body's load bearing joints.
Pain on the treated side was mild without needing anesthesia.
Pain prevalence was higher in women and in older adults with obesity , musculoskeletal conditions , and depressive symptoms ( P < @number@ ) .
Pain rating was performed using the McGill Pain Questionnaire and a visual analogue score scale.
Pain reduction induced by BTX-A injection lasted for at least @number@ months while that induced by NS lasted for only @number@ month.
Pain-related reduction in attention resources may not represent a risk factor for falls among older adults with NMF.
Pain score observations ( @number@ ) from @number@ patients were included in the statistical analysis.
Pain scores increased more when individuals who experienced communication difficulty reported being depressed , compared to those who did not experience communication difficulty.
Pain scores significantly decreased over time in all age groups , with a slightly more rapid decrease for younger patients.
Pain scores were equivalent at the end of the first pass for both groups ( P = @number@ ) .
Pain severity , based on the average intensity of frequent pain , was hypothesized to be positively associated with AL.
Pain severity mean and variability were measured over @number@ days of daily self-reported pain levels.
Pain severity was significantly correlated with dementia severity , neuropsychiatric symptoms , depression , agitation , and quality of life at both time points.
Pain symptom associated with temporomandibular disfunction is followed by some changes of physiological statistics ( high sympathetic level ) .
Pain syndromes are among the most widespread , costly , and debilitating of all neurological disorders.
Pain threshold increases with age , which is indicated by a large effect size.
Painting was performed in one surface of one of the discs.
Paints where dried either at natural or at infrared light bulb method.
Pain-type-specific catastrophizing scores were more strongly related to ratings of sensory and emotional pain characteristics than standard catastrophizing scores.
Pain types were measured using the Intermittent and Constant Osteoarthritis Pain ( ICOAP ) scale.
Pain variability was measured by examining intra-individual standard deviations of daily pain scores.
Pain was associated with lower OSF , and higher SFD and CSF scores.
Pain was mainly of a mechanical nature , due to osteoarthritis or common back pain.
Pain was measured using the NRS upon initial contact of the medical staff and upon admission to our emergency department.
Pain was measured with the visual analogy scale ( VAS ) .
Pain was measured with visual analog scales , pain logbooks and questionnaires , while sleep was assessed with actigraphy , sleep diaries and questionnaires.
Pain was significantly associated ( OR @number@ @percent@ CI @number@ @date@ ) with all-cause mortality during follow-up.
Pain was significantly associated with more antipsychotic prescriptions.
Pain was the only factor associated with disagreement between the SCID and PHQ-9.
Pain was variable ( mean of @number@ @date@ ) and side effects included two cases of mild focal vesiculation.
Paired-analysis of change in the orbital rim height and width demonstrated a mean decrease over time but was not significant.
Paired associates learning ( PAL ) has been widely used in aging-related research , suggesting an age-related decline in associative learning.
Paired samples t-tests were used to examine pH levels before and after a four-day treatment period with Reserveage Wholeganic Greens ( TM ) .
Paired t- and one-way ANOVA tests were used to analyze the data ( alpha = @number@ ) .
Paired t tests and multivariable linear regression analyses were applied.
Paired t tests examined pre-post test changes in sitting time , sit-to-stand transitions , and secondary outcomes.
Paired t-tests were used to assess the effects of intervention , and chi square was used to assess interaction between measures.
Paired t tests were used to compare the preference scores between the facial stimuli with and without aesthetic unit separation.
Paired with the screening tools were educational materials designed to improve drivers ' knowledge of their own limitations , including compensating techniques.
Pair feeding was included to reveal food-independent POMC impact on energy expenditure.
Pairing training with neurostimulation may stabilize or improve WM performance by enhancing plasticity and strengthening WM-related cortical networks.
Pairwise comparison of the groups revealed highly significant differences ( p < @number@ ) .
Pairwise comparisons revealed significant differences between 20s versus 70 + for all variables and 20s versus 60s for all variables except those measured at C2.
Pairwise comparisons revealed that each increase in cognitive impairment category exhibited significantly higher proportions with any NH use.
Pairwise differences between Asian / Pacific Islanders and the other four groups were assessed using a Bonferroni correction ( p < @number@ ) .
Pairwise meta-analysis and network meta-analysis were conducted.
PA is thus a good marker against metabolic diseases.
PalAPP-dimers are predominantly cis-oriented while total APP dimerizes in both cis- and trans-orientation.
PalAPP forms dimers @number@.5-times more efficiently than total APP.
PA level refers to the average level of positive feelings.
PA levels decreased in subjects with probable cognitive decline , depression and high perceived stress levels ( p < 0.001 ) .
Palliative care and cardiac services need to integrate their services defining the primary care lead with heart failure nurses coordinating.
Palliative care consultation teams ( PCCTs ) provide input to other health-care providers working with patients who have life-limiting disease.
Palliative care is essential for patient-centered care of the older cancer patients.
Palliative care is now included as part of the care pathway of a wide variety of nonmalignant diseases.
Palliative care needs are growing with the aging population.
Palmar skin is highly porous to water and contains abundant specialized vasculature densely innervated by sympathetic nerves and has unique epidermal anchoring for gripping purposes.
Palmitic acid incorporation into lipids in myotubes decreased with passage number and could be explained by reduced incorporation into diacyl- and triacylglycerols.
Palmitoylated APP ( palAPP ) shows greater preference for β-cleavage than total APP in detergent resistant lipid rafts.
Palmore's FAQ version @number@ and Facts on Aging Mental Health Quiz were used as bases for the development of a revised FAQ instrument.
Palpitation , sweating , nausea , diarrhea and dizziness have all been observed in elderly patients taking parasympathomimetic drugs.
PAMAM dendrimers increased the solubility and stability of resveratrol in water and semisolid dosage forms.
Panax ginseng and ginsenosides have promising properties in preventing skin aging.
Panax ginseng Meyer ( Ginseng ) has been used widely in traditional herbal medicine because of its pharmacological activities.
Pan-caspase inhibitor reduced apoptosis but showed weaker inhibition of cell proliferation than the autophagy inhibitor.
Pancreatic cancer incidence and lethality rates were estimated from SUS hospitalizations and in-hospital PC deaths and adjusted to total available hospital beds.
Pancreatic cancer remains an urban disease in Brazil , the highest incidence found in the most developed regions as in large metropolitan integrated municipalities.
Pancreatic enzymes are able to normalize protein digestibility in CF , albeit with a severe delay.
Pancreatic enzymes were ingested after @number@ h in CF and the response in protein digestibility was assessed.
Pancreatic fistula rate was @percent@ ( 52 / 323 ) , @number@ patients died for pancreatic fistula PF.
Pancreatic islets express high levels of the orphan G-protein coupled receptor C5C ( GPRC5C ) , the function of which remains to be established.
Pancreatic islets secrete hormones that play a key role in regulating blood glucose levels ( glycemia ) .
Pancreatic polypeptide ( PP ) is a major agonist for neuropeptide Y4 receptors ( NPY4R ) .
Pancreatic tissue from a total of @number@ human fetuses and adults was stained for Ki67 , cyclin D3 , p16 and p27 , and insulin.
Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 ( GLP-1 ) .
Panel data from the Health and Retirement Study are examined using Cox regression techniques.
Panel members aged @number@ years and older and who have access to and use the Internet were selected ( N = 1418 ) .
PanINs with or without cancer showed similar telomere lengths.
Panoramic radiographs of @number@ subjects ( @number@ women and @number@ men ) aged between @number@ to @number@ years were used.
PaParp overexpressors are impaired in growth , in pigmentation and fertility , and have a shortened lifespan.
PAPD5 knockdown caused an increase in the miR-21 expression level , suggesting that PAPD5-mediated adenylation of miR-21 leads to its degradation.
PAPERCLIP.
PAPERCLIP.
Papers were excluded if data regarding elderly aged > 79 years were absent.
Papillary carcinomas were positive to E-cadherin expression , while the follicular carcinomas lose E-cadherin staining.
Papillary clusters were occasionally found.
Papillary dermis of living subjects , covering a wide age range , was imaged immediately before and forty days after treatment.
Papillary renal cell carcinoma ( pRCC ) is the second most frequent renal cell carcinoma ( RCC ) after clear cell RCC.
PAPP-A is associated with renal function and proteinuria , is increased mainly in dialysis patients and decreases after kidney transplantation.
PAPP-A levels can be influenced by various chemicals and drugs , among them mainly heparin.
PA programs may want to further assess their students ' attitudes to older adults and implement interventions to improve them , where indicated.
PAP was divided into @number@ grades based on the presence and severity of fat atrophy and the existence and depth of superior sulcus deformity.
Par4 , CEBPB and FAK form a senescence signaling pathway , playing roles in modulating cell survival , growth , apoptosis , EMT and self-renewal.
Par4 has been reported as a tumor suppressor gene that induces apoptosis in cancer cells , but not in normal cells.
Parabiosis , which is characterised by a shared blood supply between two surgically connected animals , may just provide such a transformative experimental paradigm.
Parabiotic animal studies suggest there are factors in the systemic environment that can influence the regenerative capacity of tissues.
Paracetamol ( acetaminophen ) is generally recommended as a first-choice analgesic in osteoarthritis pain.
Paracetamol @number@ mg was given by infusion over @number@ minutes.
Paracrine mechanisms and inflammatory cytokines , such as CRP and IL-6 could be confounders of the actual underlying pathological mechanism.
PARADIGM inferred pathway analysis revealed the network connection of TP63 and NF-κB complexes through an AP-1 hub , further supporting our findings.
\ "Paradoxical \ " low-flow , low-gradient stenosis has a dismal prognosis in spite of a normal left ventricular ejection fraction.
Paradoxically , adiponectin levels are high and positively correlated with endothelin-1 , raising questions about the pro- or anti-inflammatory role of this adipocytokine in beta-thalassaemia.
Paradoxically , circulating senescent CD57 ( + ) / CD28 ( null ) CD8 ( + ) T cells were associated with better PFT outcomes.
Paradoxically , during the period when prevention efforts could make a difference , this population receives psychosocial treatment at best.
Paradoxically , however , disruption of chromatin structure may also promote cancer.
Paradoxically , however , space travel has been recently shown to be beneficial to some aspects of muscle health in the tiny worm Caenorhabditis elegans.
Paradoxically , however , this is in spite of a higher prevalence of CVD risk factors.
Paradoxically , introduction of an activated oncogene leads to activation of a state similar to cellular senescence , which is referred to as oncogene-induced senescence.
Paradoxically , it is a sign of life.
Paradoxically , lean mass was similar between groups , and muscle fiber area was greater in OO vs OL ( P = @number@ ) .
Paradoxically , older people suffering from cancer are often excluded from clinical trials and are undertreated when compared to younger patients.
Paradoxically , older volunteers exhibited the highest frequency of volunteering , operationalized as spending @number@ hours or more on volunteer work in the past month.
Paradoxically , over the last @number@ years , the number of dentists in Bulgaria increased by more than @percent@ from @number@ to @number@
Parakeratosis is frequent with aging because of microtraumas , in many cases is expression of permanent inflammation.
Parallel in vitro studies showed that P2Y12 receptor blockade by the reversible antagonist PSB-0739 sensitizes CD to the action of AVP.
Parallel-polarized photography enhanced visualization of skin texture.
Parallel processing of isolated neurons and bulk tissue allowed the discrimination of neuronal and glial transcription signals.
Parallel process mixed effects regression models characterized longitudinal trajectories of cognitive variables and time-varying changes in brain volumes.
Parallel process modeling found that perceived control at age @number@ predicted gains through age @number@ in years of postsecondary education.
Parallel RNA-Seq expression analysis of the plasmid reporter identifies novel transcriptional mutagenesis properties of εC.
Parallels between nursing practices of the past and present are discussed.
Parallel signaling mechanisms lead to cell-specific control and recruitment of downstream factors , including various kinases , transcription factors and ion channels.
Parallel studies in vitro found that exogenous NO and Rb1 shRNA increased ENS precursor DNA replication and nuclear size.
Parallel to genetic approaches , genome-wide approaches have provided valuable insights for the understanding of molecular mechanisms occurring during aging.
Parallel to technical advancements possibilities for the analysis of the human proteome for biomarkers have recently made considerable progress.
Parallel to these cognitive impairments are marked disruptions in sleep physiology.
Paramedics are uniquely positioned to play a larger role in the care of our aging population.
Paramedics are well positioned to play an important role via a more thorough evaluation of frailty ( or vulnerability ) .
Parameter estimate for age and atazanavir AUC after adjusting for gender and BW was @number@ ( @percent@ CI @number@ @date@ ) .
Parameters affecting PWV were evaluated by regression analysis.
Parameters F2 and F3 were obtained by the multiple suction method.
Parameters for exploring statistical heterogeneity are pre-specified.
Parameters included in this model were analysed by cox regression.
Parameters in the FLoSS formula can be tailored for studies of specific populations or age ranges or with different conditions.
Parameters of diffusivity and anisotropy are used to evaluate white matter and fibre integrity as well as axonal and myelin degeneration.
Parameters of HRV were derived from 24-hour Holter monitoring.
Parameters referring to the recovery phase change stronger with aging.
Parameters were analyzed according to a standard postprocessing protocol.
Parametric bivariate statistics and logistic regression models were used to analyze data at RESULTS : A total of @number@ participants were included in this study.
Parametric images of AChE activity were analyzed using standard atlas regions.
Paranoid and psychotic symptoms were noticed among @percent@ and @percent@ of elderly , respectively.
Paraoxonase-1 ( PON1 ) is a serum arylsulfatase that metabolizes organophosphate pesticides and protects low-density lipoprotein from oxidation.
Parasagittal images of @number@.5-mm thickness perpendicular to the internal auditory canal were reconstructed from @number@.4-mm thick axial 3D-CISS images for all ears.
Parasympathetic activity and HRV have been associated with a wide range of conditions including CVD.
Parathyroid hormone action is activated in the elderly , which contributes to the inhibition of excess signal transduction in energy-deficient CNS.
Parathyroid hormone elevation is associated with increased IMT.
Parathyroid hormone ( PTH ) , when applied intermittently in vivo , has osteoanabolic effects in a variety of systems.
Parathyroid hormone receptors ( PTHR ) are widely expressed and PTH is the only anabolic therapy for osteoporosis.
Parcellation of the subcortical white matter was performed on 3D T1-weighted volumes using Freesurfer.
Parenchymal findings were more prevalent in the older group ( @number@ vs. @percent@ in the younger group ; p < @number@ ) .
Parental age at birth displays a negative association with offspring longevity.
Parental age can also influence dominant characters , sex ratio , personality and development process of the offspring.
Parental history of diabetes was positively associated with T2DM incidence.
Parental longevity may be a valuable trait for identifying early biomarkers for resistance to cognitive decline in aging.
Parental longevity was defined as having at least one parent survive to age ≥85 years.
Parents and professionals should pay attention to suicide risk in adolescents with PfS.
Parents ' education predicted both higher levels of perceived control and enrollment in full-time postsecondary education at age @number@
Parents provided measured height and weight data for their children.
Parents provided verification of children's memories and age estimates.
Parents reported words as being learned earlier , and bilinguals reported learning them later.
Parents ' support of sons , as well as the parents ' own needs and sons ' capabilities all affect the support provided by sons.
Parents were equally active at both ages in trying to elicit children's help but used different strategies with younger and older toddlers.
Parents who found giving support to be highly rewarding had lower levels of depressive symptoms when giving high amounts of tangible support.
Parietal white matter changes were not the predominant correlate with motor speed , lending evidence to a global involvement of neural networks in gait velocity.
Parity showed little seasonal trend despite fluctuations in vector densities over the year.
Parkinson disease is a progressive neurodegenerative disease for which leucine-rich repeat kinase @number@ ( LRRK2 carriers ) p.G2019S confers substantial genotypic and population attributable risk.
Parkinson disease ( PD ) is common in long term care ( LTC ) facilities.
Parkinson disease ( PD ) is increasingly prevalent in the aging population.
Parkinson disease ( PD ) is second only to Alzheimer disease as the most common neurodegenerative disorder in humans.
Parkinson disease ( PD ) is the most common movement disorder.
Parkinson disease ( PD ) is the second most common neurodegenerative disorder.
Parkinsonian gait and other mild parkinsonian signs were assessed with a modified version of the original Unified Parkinson's Disease Rating Scale ( mUPDRS ) .
Parkinsonian signs were assessed with a modified version of the motor section of the Unified Parkinson's Disease Rating Scale.
Parkinsonism was assessed by UPDRS III and Purdue pegboard.
Parkinson's disease and atypical forms of parkinsonism occur mainly in the elderly , with oxidative stress and inflammation in afflicted cells.
Parkinson's disease and healthy aging : Independent and interacting effects on action selection.
Parkinson's disease causes incapacity to work and a large number of days off from work.
Parkinson's disease is a debilitating , age-associated movement disorder.
Parkinson's disease is a progressive , neurodegenerative disorder affecting millions of people worldwide.
Parkinson's disease is characterized by progressively distributed Lewy pathology and neurodegeneration.
Parkinson's disease , like many common age-related conditions , is now recognized to have a substantial genetic component.
Parkinson's disease ( PD ) , a degeneration of nigro-striatal DA neurons is the most conspicuous reflection of the vulnerability of DA neurons to age.
Parkinson's disease ( PD ) and aging lead to gait impairments.
Parkinson's disease ( PD ) and normal aging have been associated with changes in visual perception , including reliance on external cues to guide behavior.
Parkinson's disease ( PD ) has a number of known genetic risk factors.
Parkinson's disease ( PD ) is a common neurodegenerative disease characterized by the selective loss of the dopaminergic ( DA ) neurons in substantia nigra.
Parkinson's disease ( PD ) is a common neurodegenerative disease resulting from complex interaction involving genetic and environmental risk factors on background of aging.
Parkinson's disease ( PD ) is a common neurodegenerative disease whose pathological hallmark is the accumulation of intracellular α-synuclein aggregates in Lewy bodies.
Parkinson's disease ( PD ) is a late-onset neurodegenerative disease which occurs at more than @percent@ in populations aging 65-years and over.
Parkinson's disease ( PD ) is an aging-associated neurodegenerative disease affecting millions worldwide.
Parkinson's disease ( PD ) is a neurodegenerative disease with multiple etiologies.
Parkinson's disease ( PD ) is a neurodegenerative disorder caused by nigrostriatal dopaminergic degeneration.
Parkinson's disease ( PD ) is a neurodegenerative disorder characterized by motor and non-motor symptoms.
Parkinson's disease ( PD ) is a neurodegenerative disorder , whose cardinal pathology is the loss of dopaminergic neurons in the substantia nigra.
Parkinson's disease ( PD ) is a progressive neurodegenerative disorder characterized by motor disturbances , appearance of Lewy bodies and dopaminergic neuronal death.
Parkinson's disease ( PD ) is a progressive neurodegenerative disorder of the basal ganglia.
Parkinson's disease ( PD ) is a progressive neurodegenerative disorder of unclear etiology and pathogenesis.
Parkinson's disease ( PD ) is associated with episodic memory deficits , but their exact nature is unclear.
Parkinson's disease ( PD ) is associated with oxidative stress and mitochondrial dysfunction and recent work suggests a role for PGC-1α.
Parkinson's disease ( PD ) is associated with procedural learning deficits.
Parkinson's disease ( PD ) is characterized by the progressive degeneration of nigrostriatal dopaminergic neurons leading to motor deficits.
Parkinson's disease ( PD ) is one of the most common neurodegenerative diseases affecting an increasing number of people worldwide with the aging society.
Parkinson's disease ( PD ) is one of the most devastating neurodegenerative disorders.
Parkinson's disease ( PD ) is the most common form of degenerative Parkinsonism with a prevalence of @percent@ of those older than @number@ years.
Parkinson's disease ( PD ) is the most frequent neurodegenerative movement disorder.
Parkinson's disease ( PD ) is the second most common neurodegenerative disease.
Parkinson's disease ( PD ) is the second most common neurodegenerative disorder.
Parkinson's disease ( PD ) is the second most common neurodegenerative disorder after Alzheimer's disease.
Parkinson's disease ( PD ) is the second most prevalent late-onset neurodegenerative disorder that affects nearly @percent@ of the global population aged @number@ and older.
Parkinson's disease ( PD ) patients develop progressive cognitive decline.
Parkinson's disease ( PD ) patients typically suffer from motor disorders but mild to severe cognitive deficits can also be present.
Parotid ADC measurements are strongly influenced by fat saturation.
Parotid ADC measurements are strongly influenced by fat saturation.
Parous rs2002555 G / G carriers had menopause @number@ yr later compared with A / A carriers ( P = @number@ ) .
Paroxysmal AF was an independent risk factor for survival in patients with CKD but not in those without CKD.
Paroxysmal atrial fibrillation ( AF ) is a major cause of cryptogenic stroke with incidence expected to rise with the aging population.
PARP1 was recruited to DNA damage within condensed chromatin more efficiently than in active chromatin.
Partial clearance rates were @percent@ , @percent@ , and @percent@ respectively ( both P < .001 versus vehicle ) .
Partial correlation analysis after controlling for age and education was used to evaluate associations between cognitive performance and DTI parameters.
Partial correlation analysis was used to analyze factors influencing the discordance.
Partial correlation and mediation analyses estimated age-related variance in cognition shared with individual brain markers and unique to each marker.
Partial correlation coefficients were computed to determine whether cognitive measures were related to serum L + Z and MPOD.
Partial correlations and linear regression models were used to examine the HOMA-IR-executive function relationship.
Partial correlation was used to observe age-related correlations within and between resting-state networks.
Partial deletions of the gene encoding the neuronal splicing regulator RBFOX1 have been reported in a range of neurodevelopmental diseases , including idiopathic generalized epilepsy.
Partial Directed Coherence was computed by means of General Linear Kalman Filter and graph indexes were extracted from estimated patterns.
Partial-intervention counties ( @number@ counties ) received only the television-based social marketing campaign.
Partial irradiation of the thyroid did not affect the function and volume of the thyroid.
Partial Least Squares Structural Equation Modeling ( PLS-SEM ) was used to predict children's BMI scores at age @number@
Partialled ( by age , body mass index , race , and sex ) and weighted common correlations were calculated between biomarkers and physical performance.
Partially acculturated populations had higher pulse pressures than unacculturated populations.
Partial reprogramming may point the way to new antiaging and proregenerative therapeutics.
Partial sleep deprivation alters the human gut microbiome , and its composition is associated with cognitive flexibility in animal models.
Partial Spearman correlations were used to estimate associations between PAEE and each accelerometer metric.
Partial Spearman's correlation , generalized additive models , and receiver operating characteristic ( ROC ) analysis were used to assess associations of kynurenines with PLP.
Partial volume correction ( PVC ) was performed in the VOI analysis.
Partial volume effects ( PVEs ) exist in sampling signal for many physical and actual reasons , which lead to inaccurate fiber imaging.
Participant adherence to recommendations ranged from low ( @percent@ ) , to moderate ( @percent@ ) , to high ( @percent@ ) .
Participant age , sex , smoking , depressive symptoms , work status , wealth , and long-standing illness were recorded at baseline.
PARTICIPANT : All patients over @number@ years old consecutively hospitalized between January and @date@ .
Participant assessments included on-road driving safety and cognitive functioning in visuospatial construction , speed of processing , memory , and executive functioning.
Participant characteristics were assessed via questionnaires.
Participant characteristics were examined according to baseline restricted life-space using the chi-square test and Student's t-test.
Participant data were collected through home visits.
Participant data were linked with death records from the National Health Service registries from @number@ to @number@
PARTICIPANT : Participant food intake assessment was available at baseline for @number@ subjects ; information on survival was available for @number@ at the @number@ follow-up.
Participant preference for optional treatment at the end of the study favoured mono-HA.
Participant-rated severity of treatment-related reactions was mainly mild and transient.
Participant referral sources , eligibility , enrollment status , demographics , and loss to follow-up were tracked in a relational access database.
Participant-reported physical activity data were collected in @number@ ( baseline ) , @number@ @number@ @number@ @number@ and @number@
Participant residences were geocoded and categorized according to US Department of Agriculture Rural-Urban Continuum Codes.
PARTICIPANTS : 60 + years of age ( n = @number@ ) .
Participants achieving early proficiency were on average younger.
Participants acknowledged both positive and negative changes in roles and obligations as they aged which impacted on continuity of identity.
PARTICIPANTS : A combined sample of @number@ people with mild , moderate , and severe dementia.
PARTICIPANTS : A community dwelling of older adults ( N = @number@ ) from the Vienna Transdanube Aging study.
PARTICIPANTS : A convenience sample of @number@ centenarians.
PARTICIPANTS : Acute psychiatric inpatients aged ≥50 years who met inclusion criteria ( N = 374 ) .
PARTICIPANTS : Admissions to the GARU during a six-month period were included.
PARTICIPANTS : Admitted individuals referred for CGA.
PARTICIPANTS : adults aged / mean age of 65 + .
PARTICIPANTS : Adults aged @number@ and older.
PARTICIPANTS : Adults aged @number@ and older.
PARTICIPANTS : Adults aged @number@ and older undergoing major noncardiac surgery ( N = @number@ ) .
PARTICIPANTS : Adults aged @number@ and older with cancer undergoing chemotherapy.
PARTICIPANTS : Adults aged @number@ and older with kidney cancer treated surgically from @number@ to @number@ ( N = @number@ ) .
Participants : Adults with baseline TSH @number@ to @number@ mIU / L. Main Outcome Measures : Primary outcome was incident hip fracture.
PARTICIPANTS : Adults with or at risk for type @number@ diabetes.
PARTICIPANTS : Adults with type @number@ diabetes.
PARTICIPANTS : African-American churchgoers.
PARTICIPANTS : African Americans ( n = 2 , 284 ) and non-Hispanic whites ( @number@ ) with a mean age of @number@
Participants aged 57-84 years passed a geriatric assessment and responded to a health economic questionnaire.
Participants ( aged 60-88 years ; The increased life expectancy and the expansion of the elderly population are stimulating research into aging.
Participants aged ≥66 years and living at home ( n = @number@ ) at baseline underwent interviews and clinical examination.
Participants aged @number@ and above were included in the study ( N = @number@ ) .
Participants aged over @number@ living independently in the community were recruited through a community Agewell Centre.
Participants , aged over @number@ were categorized according to baseline clinical diagnosis ( normal cognition , MCI , or AD ) .
PARTICIPANTS : A geographic information system was used to select the sample of older people living alone , by proximity to a supermarket.
Participants ' ages at chapter beginnings and endings showed pronounced reminiscence bumps.
PARTICIPANTS : A group of @number@ @number@ and @number@ elderly residents aged ≥60 years were included this study in @number@ @number@ and @number@ respectively.
Participants alive on or after @date@ , in the Veterans Aging Cohort Study were included.
PARTICIPANTS : All adult population aged @number@ and older.
PARTICIPANTS : All consortium participants of European ancestry with known age , PCa status , and quality assured custom ( iCOGS ) array genotype data.
PARTICIPANTS : All Danish inhabitants who were diagnosed and registered with early onset schizophrenia in 1970-1979 and still alive at age @number@ years.
PARTICIPANTS : All ED visits of individuals aged @number@ and older.
PARTICIPANTS : All living Danes born in @number@ were approached in @number@ @number@ responded at baseline.
PARTICIPANTS : All patients from @number@ primary care centers with the diagnosis of heart failure in medical records were included.
PARTICIPANTS : All published white and Asian case-control data sets , which included a total of @number@ cases and @number@ controls.
PARTICIPANTS : All residents.
Participants : All were diagnosed with POI prior to age @number@ years and presented with elevated follicle-stimulating hormone levels.
Participants also believed that the cognitive decline that accompanies older age may limit HA benefit.
Participants also completed a battery of neuropsychological tests targeting relational memory and inhibition ability.
Participants also completed a classic time-production task and several executive tasks assessing inhibition , updating and shifting processes.
Participants also completed an evaluation at the conclusion of the training to report change in personal attitude and individual response to the curriculum.
Participants also completed Apathy Evaluation Scale , Beck Depression Inventory-II and Addenbrooke's Cognitive Examination-Revised.
Participants also completed tasks of word recall and recognition and visuospatial working memory.
Participants also completed the Beck Depression Inventory-II ( BDI-II ) .
Participants also completed the NEO Personality Inventory-Revised ( NEO PI-R ) and an annual cognitive examination.
Participants also designated who was considered the key decision maker.
Participants also did not suggest that older people considering suicide seek help from the health system.
Participants also performed actual and imagined crossings of this \ "road \ " as well as a duration production task.
Participants also performed a neuropsychological battery tapping episodic memory and executive functions.
Participants also performed offline cognitive tasks evaluating executive functions , working memory , and attention.
Participants also performed several measures of episodic and nonepisodic cognition from which common episodic and nonepisodic factors were extracted.
Participants also performed single-task standing.
Participants also performed the Text Reception Threshold ( TRT ) test , a test of processing speed , and a word vocabulary test.
Participants also provided a 3-cm-long hair strand to index cortisol accumulation over the past @number@ months.
Participants also reported experiences of marginalization in health care that hindered retention in care and ART adherence.
Participants also reported markedly increased use of cognitive screening tools in providing care.
Participants also reported on average @number@ occurrences of multilevel trauma and stressful life events and lingering subjective distress related to these events.
Participants also reported parental personal problems , parental disability status , relationship quality , and support that parents provide offspring.
Participants also underwent a magnetic resonance imaging of the brain.
Participants also underwent comprehensive neuropsychological testing.
PARTICIPANTS : Ambulatory community-dwelling older adults without dementia ( N = @number@ mean age @number@ @percent@ female ) .
PARTICIPANTS : Ambulatory older adults without dementia ( N = 104 ) .
PARTICIPANTS : American Chinese aged @number@ years and older were enrolled using random cluster sampling and volunteer screening in the Chinatown district of San Francisco.
PARTICIPANTS : A national probability sample of @number@ home-dwelling older U.S. adults assessed at baseline ( @date@ ) and 5-year follow-up ( @date@ ) .
PARTICIPANTS : A national probability sample of @number@ men and women @number@ years of age or older.
PARTICIPANTS : A national representative sample of @number@ non-institutionalized older adults ( 65-84years ) .
PARTICIPANTS : A national sample of @number@ men and @number@ women aged @number@ and older without functional disability at baseline.
PARTICIPANTS AND DESIGN : eighty-two patients aged > 75 years ( mean age @number@ ± @number@ years ) were randomised to receive NIV or SMT.
PARTICIPANTS AND MEASUREMENTS : The analytic sample for this study included @number@ women aged 76-86 years old who underwent DXA evaluation at round @number@
PARTICIPANTS AND MEASUREMENTS : The participants were grouped into frail , pre-frail , and robust groups according to the revised Fried frailty criteria.
PARTICIPANTS AND METHODS : A total of @number@ healthy , active adults aged 66±5 years completed the randomized controlled trial.
PARTICIPANTS AND METHODS : A total of @number@ participants older than @number@ years underwent physical examinations and laboratory analyses following standardized protocol.
PARTICIPANTS AND METHODS : The survey was conducted involving @number@ participants , aged @number@ or above with cross-sectional study of population.
PARTICIPANTS AND METHODS : This is a cross-sectional and methodological study.
Participants and physicians evaluated improvement using pre- and post-treatment photographs.
PARTICIPANTS AND RESEARCH CONTEXT : In total , @number@ older persons aged 70-96 years were interviewed , @number@ men and @number@ women.
Participants and researchers were blinded to group assignment.
PARTICIPANTS AND SETTING : @number@ community-dwelling Singaporeans aged @number@ years and over.
PARTICIPANTS AND SETTING : @number@ free-living elderly women aged 70-85 years at baseline from a cohort of @number@ elderly women.
PARTICIPANTS AND SETTING : @number@ residents , living in @number@ aged care facilities.
PARTICIPANTS AND SETTING : Participants were HIV-infected patients enrolled in the Veterans Aging Cohort Study between 2002-2008 who were receiving antiretroviral medications.
PARTICIPANTS AND SETTING : Pregnant women were recruited upon hospital delivery admission.
PARTICIPANTS AND STUDY DESIGN : @number@ healthy postmenopausal women , 50-60 years old , provided blood samples at baseline and following a one-month lycopene-depletion period.
Participants and their informants also completed a questionnaire assessing everyday PM failures.
PARTICIPANTS : An interprofessional specialty team at a tertiary care center and staff from @number@ long-term care sites.
Participants answered questions regarding health status and physical activity and performed functional tests.
Participants answered questions regarding indicators of HS , SES and also PA and I through interviews.
Participants answered questions regarding psychological , physical , and sexual abuse , caregiver neglect , and financial exploitation.
Participants ' answers were compared to concept maps defining the instrument concepts in detail.
PARTICIPANTS : Any patient with no known ocular disease who desires a routine eye screening examination is eligible.
PARTICIPANTS : A panel of vitreoretinal disease experts was the foundation of the International Classification System.
PARTICIPANTS : A population-based sample of @number@ older adults with chronic and primary insomnia.
PARTICIPANTS : A randomized selection from the Swedish Twin Register included @number@ persons , all still living at home.
PARTICIPANTS : A random sample of @number@ adults in the Hezuo community in Chengdu , China , completed the survey in @number@
Participants are excluded if they do not speak English , Spanish , Cantonese , Mandarin , or Korean or if they are unable to consent.
Participants are not VA patients ; rather , they receive their medical and dental care in the private sector.
Participants are @number@ American women , ages 39-49 , who responded to a detailed self-administered mailed questionnaire.
PARTICIPANTS : A representative community sample of @number@ individuals aged @number@ and older ( mean age @number@ @percent@ female ) .
PARTICIPANTS : A representative sample of Medicare beneficiaries aged @number@ and older.
Participants are randomised into either the diet group or control group.
Participants are randomized in a 1 : 1 allocation ratio.
PARTICIPANTS : A sample of @number@ individuals with comprehensive baseline analyses participating in a longitudinal study of cognitive decline and early Alzheimer disease.
Participants associated falls with physical disability , a loss of emotional well-being and loss of connection to family and community.
PARTICIPANTS : A subsample of @number@ Mexican Americans aged at least @number@ years without diabetes at baseline were followed for @number@ years.
PARTICIPANTS : A subsample of @number@ non-institutionalized survey participants aged > 60 years with measures of body composition using bioimpedance.
Participant satisfaction ratings were assessed using a pre-tested 10-point assessment scale.
PARTICIPANTS : A total of @number@ adults aged 58-100 years.
PARTICIPANTS : A total of @number@ adults ages 70-89 years , sedentary , without dementia , and with functional limitations.
PARTICIPANTS : A total of @number@ African-American adults @number@ years of age and older with mild to severe depressive symptoms.
PARTICIPANTS : A total of @number@ ambulatory elders from two longitudinal studies without baseline clinical dementia or history of stroke or Parkinson disease.
PARTICIPANTS : A total of @number@ Chinese elderly aged @number@ years and older were included in the sample.
PARTICIPANTS : A total of @number@ chronically-ill elderly outpatients aged from @number@ to @number@ years.
PARTICIPANTS : A total of @number@ community-dwelling 65- to 90-year-old men.
PARTICIPANTS : A total of @number@ community-dwelling elderly people aged @number@ years or over without depressive symptoms at baseline.
PARTICIPANTS : A total of @number@ community-dwelling older adults.
PARTICIPANTS : A total of @number@ elderly people ( mean age @number@ ) participated in the observational study.
PARTICIPANTS : A total of @number@ elderly subjects ( @number@ men ) without dementia ranging in age from @number@ to @number@ years.
PARTICIPANTS : A total of @number@ eyes of @number@ patients with glaucoma and @number@ eyes of @number@ normal individuals.
PARTICIPANTS : A total of @number@ geriatric / rehabilitation patients and @number@ aged care residents.
PARTICIPANTS : A total of @number@ healthcare professionals aged 23-43 years , @percent@ women.
PARTICIPANTS : A total of @number@ individuals aged @number@ years or older.
PARTICIPANTS : A total of @number@ KNHANES and @number@ NHANES participants were included.
PARTICIPANTS : A total of @number@ men and @number@ women , aged @number@ years and older , still alive after @number@ years of follow-up.
PARTICIPANTS : A total of @number@ men and @number@ women , mean ( standard deviation ) age @number@ ( @number@ ) years.
PARTICIPANTS : A total of @number@ men and women aged @number@ years or older.
PARTICIPANTS : A total of @number@ men and women age @number@ ± @number@ years participated.
PARTICIPANTS : A total of @number@ NH residents.
PARTICIPANTS : A total of @number@ noncomatose patients who were aged @number@ years or older.
PARTICIPANTS : A total of @number@ @number@ healthy subjects covering all ages from birth to senescence participated in the study.
PARTICIPANTS : A total of @number@ @number@ individuals were selected for the analyses.
PARTICIPANTS : A total of @number@ @number@ women and @number@ @number@ men participated.
PARTICIPANTS : A total of @number@ nursing home resident living in @number@ nursing homes.
PARTICIPANTS : A total of @number@ older adults participating in an ongoing national survey.
PARTICIPANTS : A total of @number@ older persons ( women @percent@ ) living in @number@ French nursing homes.
PARTICIPANTS : A total of @number@ oldest old ( ≥85 years ) women.
PARTICIPANTS : A total of @number@ patients aged @number@ years or older admitted between @date@ and December @number@
PARTICIPANTS : A total of @number@ patients @number@ years of age and older who underwent frailty screening.
PARTICIPANTS : A total of @number@ patients who underwent cardiac surgery.
PARTICIPANTS : A total of @number@ patients with a mean age of @number@ ± @number@ years were involved.
PARTICIPANTS : A total of @number@ patients with probable AD.
PARTICIPANTS : A total of @number@ patients with type @number@ diabetes ( dementia = @number@ no dementia = @number@ ) .
PARTICIPANTS : a total of @number@ people aged @number@ or more in four waves of the English Longitudinal Study of Ageing.
PARTICIPANTS : A total of @number@ people ( mean age = @number@ @percent@ women ) assessed between @number@ and @number@
PARTICIPANTS : A total of @number@ residents participated - @number@ were female ( @percent@ ) .
PARTICIPANTS : A total of @number@ respondents from @number@ hospitals in Japan underwent gastrostomy tube replacement and management between @date@ and @date@ .
PARTICIPANTS : A total of @number@ senior center members ( @number@ male , @number@ female ) @number@ years and older.
PARTICIPANTS : A total of @number@ subjects aged ≥50 years were participated.
PARTICIPANTS : A total of @number@ subjects , aged @number@ years old or above , with or without MCI.
PARTICIPANTS : A total of @number@ subjects with MCI , @number@ cognitively normal older individuals ( controls ) , and @number@ patients with Alzheimer disease.
PARTICIPANTS : A total of @number@ US male physicians aged ≥ @number@ years.
PARTICIPANTS : A total of @number@ veterans @number@ years and older without cardiovascular disease at study baseline ( 2000-2003 ) .
Participants attained @percent@ ( n = 535 ) of goals.
Participants attended a presentation titled Hearing Health in Older Adults , which was delivered by a trained presenter in a peer-teaching-peer format.
Participants attending the focus group session indicated that the exercise program was manageable , beneficial , and enjoyable.
Participants at the intervention group were @number@ times more likely to improve their FI-combined score at both time points compared to the placebo group.
Participants averaged @number@ years old , and four of them are over hundred ( one person was @number@ years old ) .
PARTICIPANTS : A volunteer sample of @number@ persons ( mean baseline age @number@ @percent@ African American ) living independently.
Participants ' balance abilities were assessed pre- and postintervention.
PARTICIPANTS : Baseline sample of @number@ adults aged 65 + from a representative registry.
Participants ' beliefs about the ideal and latest age a woman or man should consider producing a child decreased.
Participants believed that older age led to cognitive decline , which resulted in decreased speech understanding.
Participants below the @percent@ poverty delimiter were slightly younger than those above the delimiter.
PARTICIPANTS : Canadian Study of Health and Aging @number@ wave.
PARTICIPANTS : Cancer patients aged > 60 years.
PARTICIPANTS : Caregivers were aged ≥ @number@ years , lived with patients , and provided ≥ @number@ hours of daily care.
Participants categorized bidimensional stimuli either by picture or by color , depending on their spatial position in a 2-cell vertical grid.
PARTICIPANTS : Children transfused with one or two units of blood in the perioperative period.
PARTICIPANTS : Chinese-American older adults aged @number@ and older interviewed from @number@ to @number@ ( N = @number@ ) .
PARTICIPANTS : Chinese individuals with ( n = @number@ ) and without ( n = @number@ ) AD.
Participants : Chinese male elderly ( n = @number@ ) .
Participants choosing home-and-community-based care were regarded as the reference group.
Participants , clinicians , and investigators were blinded to group assignment.
PARTICIPANTS : Clinicians ( N = 32 ) from centers across Canada participated in this study.
PARTICIPANTS : Cognitively intact survivors of the third wave ( N = @number@ ) , who provided blood samples for standard laboratory work.
PARTICIPANTS : Cognitively normal elderly adults ( N = @number@ median age @number@ @percent@ female ) .
PARTICIPANTS : Cohort recruited in @number@ via a random sampling design from Victorian elementary schools.
PARTICIPANTS : Cohort study of @number@ persons representative of the noninstitutionalized population aged @number@ and older in Spain.
Participants collectively reviewed data retrieved from the Discovery Tool and identified and prioritized important , yet feasible , issues to address.
PARTICIPANTS : Community-dwelling adults aged @number@ and older recruited from a random sample of Medicare beneficiaries ( N = @number@ ) .
PARTICIPANTS : Community-dwelling adults aged @number@ years and older ( N = 7968 ) .
PARTICIPANTS : Community-dwelling African Americans ( ≥55 ) with depressive symptoms living in an urban area ( N = @number@ ) .
PARTICIPANTS : Community-dwelling and institutionalized men and women recruited through general practices ( N = @number@ ) .
PARTICIPANTS : Community-dwelling elderly ( n = 1138 ) .
PARTICIPANTS : Community-dwelling first-generation KAE ( N = @number@ mean age ± SD : @number@ ± @number@ years ; female : @percent@ ) .
PARTICIPANTS : Community-dwelling homebound adults aged @number@ to @number@ ( N = @number@ ) .
PARTICIPANTS : Community-dwelling individuals aged @number@ and older ( N = @number@ ) .
PARTICIPANTS : Community-dwelling individuals aged @number@ and older with data on hearing and frailty status ( N = @number@ ) .
PARTICIPANTS : Community-dwelling individuals aged @number@ years or over.
PARTICIPANTS : Community-dwelling , initially well-functioning adults aged 70-79 years ( n = @number@ ) .
PARTICIPANTS : Community-dwelling Medicare enrollees ( N = @number@ ) , @number@ of whom reported receiving rehabilitation services in the previous @number@ months.
PARTICIPANTS : Community-dwelling men aged @number@ and older ( N = @number@ ) .
PARTICIPANTS : Community-dwelling men aged @number@ y or older ( n = @number@ ) , who were free of probable dementia at sleep visit.
PARTICIPANTS : Community-dwelling men and women aged @number@ and older ( N = @number@ ) .
PARTICIPANTS : Community-dwelling older adults ( aged ≥55 ) with mild cognitive impairment ( MCI ) ( N = @number@ ) .
PARTICIPANTS : Community-dwelling older adults ( N = @number@ ) .
PARTICIPANTS : Community-dwelling older adults ( N = @number@ mean age @number@ ± @number@ ) .
PARTICIPANTS : Community-dwelling older adults with dementia and delirium ( N = @number@ ) .
PARTICIPANTS : Community-dwelling older people who attended nine memory clinics and had a diagnosis of mild cognitive impairment ( MCI ) or dementia.
PARTICIPANTS : Community-dwelling participants aged @number@ and older ( N = @number@ ) .
PARTICIPANTS : Community-dwelling people ( N = 81 ) aged ≥60 years recovering from a hip fracture.
PARTICIPANTS : Community-dwelling welfare recipients aged @number@ to @number@
PARTICIPANTS : Community-dwelling White and Black women aged @number@ and older.
PARTICIPANTS : Community-living Japanese aged @number@ to @number@ ( @number@ men , @number@ women ) .
PARTICIPANTS : Community-living Japanese aged @number@ to @number@ ( @number@ men , @number@ women ) .
PARTICIPANTS : community-living middle-aged and older persons ( age : 50-85 years ) without baseline mobility disability ( n = @number@ ) .
PARTICIPANTS : Community-living patients with Alzheimer's disease in early or moderate stage and their principal caregivers.
PARTICIPANTS : Community-residing subjects ( N = 655 ; @percent@ women ; age ≥70y ; mean , @number@.4y ) .
PARTICIPANTS : Community volunteer sample of @number@ healthy older adults , screened for normal cognition with comprehensive neuropsychological evaluation.
Participants complete comprehensive assessments at baseline , 3- and 6-month follow-ups.
Participants completed a baseline and then follow-up assessments approximately every six months for @number@ years.
Participants completed a battery of cognitive assessments and @number@ weeks of electronic medication monitoring for adherence to one antihypertensive agent.
Participants completed a battery of @number@ neuropsychological measures at baseline and then every @number@ to @number@ years.
Participants completed a mean of @number@ follow-up intervals , for @number@ total follow-up years.
Participants completed a multiple-choice questionnaire in the test session.
Participants completed an active stand ( ie , vertical stand from a supine position ) as part of a detailed clinic-based cardiovascular health assessment.
Participants completed an eight-item paired associates task daily over a 7-day period.
Participants completed an emotional WM task in which they were asked to attend to emotional targets and ignore irrelevant distractors.
Participants completed an English- or Spanish-language online survey in @date@ .
Participants completed a neuropsychological test battery , and data regarding the number of working hours ( paid and voluntary ) per week were collected.
Participants completed an on-road driving test.
Participants completed an operation span task containing mind-wandering probes.
Participants completed a phone-questionnaire on , subjective nearness-to-death , and will-to-live.
Participants completed approximately @percent@ of the daily measurements requested.
Participants completed a questionnaire detailing their smoking use in 2004-2005 , and were followed for mortality through @date@ .
Participants completed a range of self-report questionnaires on demographic variables , mindfulness , affect , quality of life ( QoL ) , and personality.
Participants completed a retroactive interference paradigm with or without contextual cues.
Participants completed a self-administered multidimensional questionnaire.
Participants completed a short questionnaire targeting background information , subjective perception of distress , attachment to the care recipient family , and the Distress Thermometer.
Participants completed as many as eight assessments of cognitive performance and anxiety over a 26-year period.
Participants completed a standardized neuropsychological battery and were assigned cognitive diagnoses using Frascati criteria.
Participants completed a standardized self-report questionnaire.
Participants completed a survey about fertility , IVF , oocyte donation ( OD ) and social oocyte freezing , between @date@ and @date@ .
Participants completed a survey measuring savoring , resilience , happiness , depression , and satisfaction with life.
Participants completed a visual target discrimination task at fixation while task-irrelevant probes were presented in both visual fields.
Participants completed batteries of tasks that measured three components of EF : updating working memory ( UWM ) , inhibition , and shifting.
Participants completed comprehensive assessments at baseline and at 4-month intervals during the first year and every @number@ months thereafter.
Participants completed four 6-min bouts of constant-load cycling at @percent@ ventilatory threshold for the determination of V̇o2 kinetics.
Participants completed four conditions of transitivity that varied in terms of the degree to which the stimuli and the relations among them were known pre-experimentally.
Participants completed functional MRI ( fMRI ) at baseline and trial completion.
Participants completed gait speed assessments using the GAITRite Electronic Walkway System , and quadriceps strength assessments using a hand-held dynamometer ( HHD ) .
Participants completed interviewer-administered disease symptom and medication use questionnaires.
Participants completed knee extensor strength testing and a physical activity questionnaire.
Participants completed measures of adverse childhood experiences related to death , trauma , and abuse , and depressive symptoms and quality of life.
Participants completed measures of PTSD symptoms , and physical , cognitive , and mental health.
Participants completed memory , reasoning , and speed of processing tests.
Participants completed neuropsychological measures of attention , executive function , memory , visuospatial judgment , and manual speed and dexterity.
Participants completed @number@ acquisition trials , followed by a 24-hour retention test.
Participants completed @number@ baseline tests , @number@ month of PBBT , and posttraining tests both @number@ week and @number@ month after training.
Participants completed @number@ gluteal rehabilitation exercises , and average normalized muscle activity was used to rank the exercises from highest to lowest.
Participants completed phone interviews within a week after the election and after a 10-month delay.
Participants completed questionnaires assessing demographics , psychological function , and substance use.
Participants completed questionnaires to evaluate their olfaction and memory function subjectively.
Participants completed self-administered questionnaires and participated in in-home interviews and observations.
Participants completed self-reporting measures on psychological distress , coping ability and social support.
Participants completed self-report questionnaires of personality traits , suicide ideation , depressive symptoms , hopelessness , perceived burdensomeness , and thwarted belongingness.
Participants completed several measures of mental and physical health , and their cognitive functioning was examined.
Participants completed study visits , including hypertension assessment , every 3-5 years starting in @number@
Participants completed surveys at baseline and week @number@ the end of instruction.
Participants completed telephone interviews about their experiences across eight consecutive days.
Participants completed the Beck Depression Inventory-II ( BDI-II ) and a 5-min resting baseline measurement of RSA was collected.
Participants completed the BSRS-5 , GDS-15 , MOS SF-12 , and a demographic survey.
Participants completed the Center for Epidemiologic Studies Depression Scale before cognitive testing and provided health and life style information during a medical history interview.
Participants completed the Knowledge of Memory Aging Questionnaire ( Cherry , Brigman , Hawley , & Reese , @number@ ) .
Participants completed the original HIS-Q every @number@ weeks.
Participants completed the Perceived Stress Scale ( Cohen et al. , @number@ ) , and for three successive days reported daily minutes of vigorous activity.
Participants completed the T25FWT and , after a rest , they then hopped using both feet @number@ times along the walkway.
Participants completed the Wechsler Test of Adult Reading and Apathy Evaluation Scale.
Participants completed three isometric tongue presses and three swallows.
Participants completed two sets of trunk forward bending and backward return task using self-selected and fast motion paces.
Participants completed up to @number@ assessments covering a 19-year period.
Participants comprised @number@ normal adults who underwent 18F-FDG PET and a neuropsychological battery.
PARTICIPANTS : Consecutive ambulatory patients who had 123I-FP-CIT SPECT for a suspicion of DLB.
Participant screenings for the NIH-funded study increased from @number@ to @number@
PARTICIPANTS : Data from @number@ hospice patients who received routine hospice care from @number@ to @number@ were analyzed.
PARTICIPANTS : Data of the entire population of Korea ( n = @number@ based on the @number@ census ) were analyzed.
PARTICIPANTS : Data were collected during preventive home visits to @number@ elderly ( age range 73-90 years ) without home-help service.
PARTICIPANTS : Dementia-free community-dwellers aged @number@
Participants ' demographics and measurements , definition of sarcopenia , and tools for evaluating cognitive function were retrieved.
Participants demonstrated knowledge deficits about the implications of aging on fertility and pregnancy , and many were unfamiliar with success rates of infertility treatments.
Participants ' depressive symptoms and disability improved significantly at both post-tests with large effect sizes ( d ranged @number@.73-2.3 ) .
Participants described key ingredients to support successful change and specifically engaging the interdisciplinary team to effect sustainable improvements in nutrition care.
Participants develop action plans related to these issues through structured planning and feedback exercises.
Participants did not use web-based best practice guidelines.
Participants did not view either device as consistently assistive.
Participants discussed that an edentulous mouth might not always be disruptive to daily functioning for all.
Participants discussed various topics of falls with their health-care providers.
Participants drank @number@ ml of water for each straw tested.
PARTICIPANTS : Drivers aged @number@ and older ( mean @number@ ± @number@ ) ( n = @number@ ) .
Participants ' driving status and health were measured at baseline , and mortality rates were observed across the subsequent @number@ years.
PARTICIPANTS : Dyads ( n = @number@ ) of distressed informal dementia caregivers and care recipients.
PARTICIPANTS : ED patients ≥65 years old who were admitted to the hospital.
PARTICIPANTS : Eight articles , with @number@ participants were included in meta-analysis and @number@ articles were included in systematic review.
PARTICIPANTS : Eight hundred fifty-nine nonagenarian siblings ( median age @number@ yr ) from @number@ long-lived families participated in the study.
PARTICIPANTS : Eighty-nine prefrail women aged @number@ years or older.
PARTICIPANTS : Eighty-two healthy elderly individuals , with @number@ subjects in the control group and @number@ subjects in the treatment group.
Participants either traded speed for accuracy or accuracy for speed regardless of age group.
PARTICIPANTS : Elderly in-patients with difficulties swallowing capsules and tablets.
PARTICIPANTS : Elderly with falls in the previous year.
Participant self-reports of complaints of poor memory by family and friends were evaluated.
Participants emphasized challenges underlying each decision to discharge patients alive , stressing that there often exists a gray line between appropriate and inappropriate discharges.
Participants endorsed neutral attitudes about late-life sexuality.
Participants ( especially older adults ) initially bet on more words than they later recalled , but greatly improved with task experience.
Participants evaluated their ability to recognise faces and were also given information about their ability to perceive and recognise faces.
Participants examined at home were excluded from analysis because they did not undergo BIA.
PARTICIPANTS : Executive directors of @number@ hospice programs , @number@ programs providing hospice and nonhospice PC , and @number@ programs providing nonhospice PC.
Participants exercised @number@ min / day , @number@ days / week for @number@ weeks on a Biodex GaitTrainer2 treadmill.
Participants expected @number@ ± @number@ mean improvement in EQ-5D within @number@ months ( P < @number@ ) that achieves the minimum clinically important difference.
Participants experienced @number@ nonspine fractures , @number@ hip fractures , and @number@ vertebral fractures.
Participants expressed a range of breast cancer beliefs , attitudes toward screening , barriers encountered , and facilitators.
Participants expressed favorable reaction to the intervention.
Participants expressed satisfaction with the program's facilitator , group discussions , and materials.
Participants ' facial expressions were videotaped during @number@ randomly ordered physical activities and coded by a qualified Facial Action Coding System coder.
PARTICIPANTS : Families and caregivers of elderly hospitalized adults ( ≥48 hours ) .
PARTICIPANTS : Family caregivers ( n = @number@ ) of community-dwelling older adults with disabilities ( n = @number@ ) .
PARTICIPANTS : Fifty healthy vegetarians ( vegetarian diet for at least @number@ years ) were recruited.
Participants : Fifty healthy young adults ( 18-29 ) and @number@ community-dwelling older adults ( 58-83 ) .
PARTICIPANTS : Fifty-one independently living people aged between @number@ and @number@ years.
PARTICIPANTS : Fifty two consenting patients with normal serum creatinine levels and no dementia.
PARTICIPANTS : Fifty-two randomly selected Group Health Medicare members between the ages of @number@ to @number@ participated.
PARTICIPANTS : Five hundred forty-four persons with a first-time stroke.
PARTICIPANTS : Five hundred forty-nine affected and @number@ unaffected individuals of Caribbean Hispanic ancestry.
PARTICIPANTS : Five hundred six patients aged @number@ years or older consecutively admitted to participating wards.
PARTICIPANTS : Five hundred sixty community-dwelling nondemented adults , aged @number@ years and older.
PARTICIPANTS : Five hundred thirty-seven adults aged @number@ and older with cognitive impairment drawn from the Health and Retirement Study ( HRS ) .
PARTICIPANTS : Five nondemented and @number@ demented participant from the Baltimore Longitudinal Study of Aging.
PARTICIPANTS : Five thousand two hundred six adults aged @number@ to @number@ from the Dynamic Analyses to Optimise Ageing ( DYNOPTA ) project.
PARTICIPANTS : Forty-five community-living residents aged 85-86 years.
PARTICIPANTS : Forty-four individuals with CF from a CF clinic and @number@ controls from a dermatology clinic.
PARTICIPANTS : Forty-nine participants aged @number@ years and older that visited an emergency department for MTBI.
PARTICIPANTS : Forty-one male volunteers aged @number@ to @number@ years.
PARTICIPANTS : Four hundred thirty older drivers , mean age @number@ recruited from clinic and community sites.
PARTICIPANTS : Four hundred thirty-two Mexican Americans aged @number@ and older with normal or high cognitive function at baseline.
PARTICIPANTS : Four hundred twenty-four sedentary , noninstitutionalized adults aged @number@ to @number@
PARTICIPANTS : Four hundred twenty-two inpatients ( mean age @number@.9±5.6years , @percent@ women ) .
PARTICIPANTS : Fourteen healthy children ( mean age @number@ ± @number@ years ; @number@ girls ) .
PARTICIPANTS : Fourteen married and cohabiting patient-caregiver pairs.
PARTICIPANTS : Fourteen thousand seven hundred fourteen retired employees ( @percent@ men ) .
PARTICIPANTS : Four thousand five hundred eighty-four men and women aged @number@ and older.
PARTICIPANTS : Four thousand five hundred seven people ( @percent@ female ) with a mean age of @number@
PARTICIPANTS : Four thousand one hundred ninety-seven community-dwelling older adults.
Participants , free of dementia , received neuropsychological assessments every two years and an MRI exam at baseline and four years later.
PARTICIPANTS : Frequency matched @number@ male and @number@ female hip fracture patients , ages @number@ or older , living in the community before fracture.
PARTICIPANTS : From @date@ to @date@ , @number@ patients with cancer aged @number@ and older.
Participants from the CG were asked not to modify their usual habits during the course of the study.
Participants from the Lothian Birth Cohort @number@ underwent brain MRI at mean age @number@ years.
PARTICIPANTS : Fruit fly Drosophila melanogaster.
Participants ' general health and cognitive status additionally influenced their ability to maintain HFS.
PARTICIPANTS : Geriatric patients aged ≥75 years with surgically repaired proximal femoral fracture.
PARTICIPANTS : Geriatric patients ( n = 105 ) with dementia ( age @number@.7±5.9 , MMSE score @number@ ) .
Participants had complete clinical history , physical examination and pure tone average conducted.
Participants had hemodynamic parameters measured using right heart catheterization during rest , passive leg raise , and incremental exercise.
Participants had repeated measurements up to @number@ years later.
Participants had their hearing and cognition measured using pure tone audiometry and Mini Mental State Examination ( MMSE ) , respectively.
Participants have been followed up longitudinally since @number@
PARTICIPANTS : Healthy community-dwelling elderly volunteers ( N = 12 ; age , 65-90y ) who could feel the maximum insole vibration.
PARTICIPANTS : Healthy young adults from two SD experiments ( combined n = 37 ; aged @number@ ± @number@ years ) .
PARTICIPANTS : Healthy young ( n = 7 , 29±3 y ) and older ( n = 7 , 67±2 y ) adults.
Participants held contrasting views about parenting : women with children drew strength from parenting whereas women without children worried that parenting could compromise their health.
Participants helped their parents financially but did not feel comfortable asking their own children for help.
Participants higher in neuroticism reported more positive affective experiences when they were with their friends , compared with times when their friends were not present.
PARTICIPANTS : Hispanic Established Populations for the Epidemiologic Study of the Elderly ( H-EPESE ) participants ( n = @number@ ) .
PARTICIPANTS : Homecare clients aged @number@ and older on polypharmacy ( N = 95 ) .
PARTICIPANTS : Home-dwelling participants ( N = @number@ ) aged between @number@ and @number@ years.
PARTICIPANTS : Hospital-based providers ( hospitalists , geriatricians , pharmacists , social workers , medical trainees , and subspecialists ) and postacute care clinicians.
PARTICIPANTS : Hospitalized individuals with CDI aged @number@ and older.
PARTICIPANTS : In all , @number@ persons aged @number@ and older.
Participants in both experiments completed audiometric testing ; participants in Experiment @number@ also completed @number@ tests of suprathreshold auditory processing.
Participants in both experiments were either warned before encoding , retrieval-practice , recall , or not at all.
Participants in both groups significantly improved on activities of daily life , mobility and quality of life over the course of the interventions.
Participants in both samples identified medical care as a key influence on QOL.
Participants in both treatment groups were satisfied with treatment.
Participants included adults who self-selected to run a marathon.
Participants included a nationally representative sample of adult's aged @number@ years and older living in Ghana.
Participants included individuals with different levels of experiences in hearing help-seeking and rehabilitation.
Participants included @number@ adults aged @number@ and older ( M = 76.3 years ; SD = 7.7 ) .
Participants included @number@ Australian women born between @number@ and @number@ alive at @date@ , free of diabetes , and eligible for data linkage.
Participants included @number@ community dwelling men who were interviewed and had clinical assessments.
Participants included @number@ community-dwelling older adults without dementia ( mean age , @number@ years ; @percent@ women ) in the Rush Memory and Aging Project.
Participants included @number@ consecutive patients examined for dysphagia from @number@ to @number@
Participants included @number@ healthy individuals without skin disease.
Participants included @number@ individuals diagnosed with aMCI , @number@ with mild AD , and @number@ healthy elderly.
Participants included @number@ individuals with serum thyrotropin levels of @number@ to @number@ mIU / L and no previously known thyroid or cardiovascular disease at baseline.
Participants included @number@ men aged ≥70 years at baseline ( 2005-2007 ) living in the community in Sydney , Australia.
Participants included @number@ older adults ( ≥65 years ) who received hearing and vision tests ; participants also completed assessments of covariates and suicide ideation.
Participants included @number@ older men , aged @number@ to @number@ who live alone in midcoast Maine.
Participants included @number@ participants ( @number@ women , @number@ men ) in the Framingham Offspring Study ( mean age @number@ years ) .
Participants included @number@ patients with Alzheimer's disease or subcortical vascular dementia , and @number@ patients with amnestic MCI or subcortical vascular MCI.
Participants included @number@ persons ( @percent@ female ) from Australia and the United States , with a mean age of @number@ ( ±13 ) .
Participants included @number@ persons with chronic localization-related epilepsy and @number@ controls , aged @number@ and @number@ respectively.
Participants included @number@ subjects , aged @number@ years and older , residing in the town.
Participants included @number@ widows and @number@ married women from the National Study of Daily Experiences II , who completed daily diaries over @number@ days.
Participants included @number@ younger , @number@ middle-aged , and @number@ older adults who completed the BTPS and a measure of life satisfaction and happiness.
Participants included @number@ young Spanish people , aged 18-30 , who completed a questionnaire about their conceptions of adulthood.
PARTICIPANTS : Included participants were community-dwelling 50-year or older adults with measured height at baseline and in follow-up.
Participants included terminally ill patients who were @number@ years or older with a life expectancy of less than @number@ year.
PARTICIPANTS : Included were @number@ community-dwelling persons @number@ years of age and older.
Participants indicated their longevity estimation was guided by three key frameworks : family history , environment and lifestyle factors and lived experience.
Participants indicated they would continue performing most tasks and reported a range of strategies to manage home maintenance challenges.
Participants indicated which member of each pair was more normal and which was more expanded.
PARTICIPANTS : Individuals affiliated with the HCSRN or OAICs and national MCC experts , including individuals affiliated with funding agencies having MCC-related grant portfolios.
PARTICIPANTS : Individuals ( aged 64-105 ) from the Medical Research Council Cognitive Function and Ageing Study ( N = @number@ ) .
PARTICIPANTS : Individuals aged @number@ and older.
PARTICIPANTS : Individuals aged @number@ and older at baseline followed for an average of @number@ years ( N = @number@ ) .
PARTICIPANTS : Individuals aged @number@ and older examined by physicians four times over @number@ years ( N = @number@ ) .
PARTICIPANTS : Individuals aged @number@ and older ( N = @number@ ) .
PARTICIPANTS : Individuals aged @number@ and older ( N = @number@ ) .
PARTICIPANTS : Individuals aged @number@ and older ( N = @number@ ) .
PARTICIPANTS : Individuals aged @number@ and older ( N = @number@ ) .
PARTICIPANTS : Individuals aged @number@ and older n = @number@ ) without prevalent basic activity of daily living ( ADL ) disability participating.
PARTICIPANTS : Individuals aged @number@ and older ( @number@ men , @number@ women ) with @number@ to @number@ years of follow-up.
PARTICIPANTS : Individuals aged @number@ and older receiving ICDs between @date@ , and @date@ ( N = @number@ ) .
PARTICIPANTS : Individuals aged @number@ and older undergoing major elective surgery ( N = @number@ ) ( majority orthopedic surgery ) .
PARTICIPANTS : Individuals aged @number@ ± @number@ ( N = @number@ ) .
PARTICIPANTS : Individuals aged @number@ to @number@ ( mean age @number@ ± @number@ @percent@ female , N = @number@ ) .
PARTICIPANTS : Individuals aged @number@ to @number@ ( N = @number@ ) .
PARTICIPANTS : Individuals aged @number@ years and above at baseline.
PARTICIPANTS : Individuals enrolled in the Progetto Veneto Anziani ( Pro.V.A. )
PARTICIPANTS : Individuals from the Einstein Aging Study autopsy series ( N = @number@ ) .
PARTICIPANTS : Individuals undergoing nonemergent major general surgeries between @number@ and @number@ were studied ( N = @number@ ) .
PARTICIPANTS : Individuals with a mean age of @number@ ± @number@ ( n = @number@ @percent@ female ) .
PARTICIPANTS : Individuals with a mean age of @number@ ± @number@ ( range 60-90 ) ( N = @number@ ) .
PARTICIPANTS : Individuals with CHF or COPD hospitalized from home ( N = @number@ ) .
PARTICIPANTS : Individuals with chronic stroke ( N = 174 ) .
PARTICIPANTS : Individuals with incident dementia registered in SveDem ( N = @number@ ) ; median follow-up @number@ days.
PARTICIPANTS : Individuals with no dementia or cognitive impairment initially.
PARTICIPANTS : Individuals with SCA ( n = 20 ) and without SCA ( n = 20 ) .
PARTICIPANTS : Individuals with two measures of BMD at the femoral neck ( mean age @number@ @number@ male , @number@ female ) .
Participants in each age group were randomly allocated to an intervention ( WBVT ) or control group.
Participants ( initial N = @number@ 53-90 years ) were from the Victoria Longitudinal Study.
Participants in later life were more accepting of ALS and of death than young and middle-aged participants.
Participants in long term care facilities were excluded.
Participants in New York ( n = @number@ ) were evaluated with the entire battery.
PARTICIPANTS : Inpatients with an average age of @number@ ± @number@ yr ( N = @number@ ) .
PARTICIPANTS : Inpatients with brain infarction and metabolic disorders.
PARTICIPANTS : Institutionalized women ≥ @number@ years old with low vitamin D status and calcium intake below @number@ mg / day.
Participants in the 3-Step Workout for Life Group performed functional movements and selected activities of daily living at home in addition to resistance exercise.
Participants in the control arm received education about brain health and participated in cognitively stimulating exercises.
Participants in the control condition did not receive intervention.
Participants in the control group ( older : n = @number@ young : n = @number@ ) completed an equally engaging filler task.
Participants in the control group received usual care prescribed by a physician and educational materials on falls prevention.
Participants in the control group were carried out daily walking for @number@ min.
Participants in the diet group received dietary advice aimed at meeting the nutritional requirements of the ageing population.
Participants in the EG underwent balance and strength training for @number@ min , three times / week for @number@ months.
Participants in the experimental arm received education about self-management , successful aging and an occupation-based meta-cognitive strategy-training program.
Participants in the fourth quartile had significantly higher total medical expenditure ( P < @number@ ) compared with the first quartile.
Participants in the Intervention condition showed significant increases on all measures , and greater improvement than participants in both Comparison and Control conditions.
Participants in the intervention group also received screening and follow-up for vision , polypharmacy , and environmental hazards.
Participants in the lowest @percent@ of the sex-specific distribution for each anthropometric and performance-based measure were classified has having low muscle mass or function.
Participants in the reinforcement intervention also evidenced greater reductions in blood pressure and weight over time and improvements in fitness indices , ps < @number@
Participants in the Resistance Exercise Only Group performed resistance exercise only.
Participants in the studies had dementia of varying degrees of severity , but all were resident in institutions.
Participants in the study were @number@ first-year social education students enrolled in an adult development and aging course.
Participants in the Tai Ji Quan group completed training sessions three times per week , while those in the control group had bi-weekly educational classes.
Participants in this study were @number@ randomly selected adults from Talca City , Chile aged 60-74 at baseline.
PARTICIPANTS : In total , @number@ older adults aged 70 + were included.
Participants in two studies were diabetic patients with varying stages of CKD , and nondialysis chronic glomerulonephritis CKD patients in two other studies.
PARTICIPANTS : Japanese-American men ( N = 3581 ; age range , 71-93y ) who were stroke free at baseline.
Participants lacked many important resources , in particular those addressing instrumental needs.
Participants later attempted to recognize previously presented items on background scenes that were original , switched , blank , or new.
Participants later re-adapted to the same conditions to assess retention of the split-belt gait pattern.
Participants ' LDT response latencies were used to assess cost of the PM task to the ongoing task.
PARTICIPANTS : Lead nurses and physicians at @number@ EDs that participated in both the T1 and T2 surveys.
Participants learned a word list containing @number@ unrelated words , presented randomly across five trials.
Participants learned to produce a coordination with a 90° relative phase relation between the dots.
Participants led the robot by maintaining physical contact and applying forces to the robot's end effectors.
Participants ' level of physical activity did not influence cognitive test performance.
Participants listened to @number@ songs , viewed @number@ faces , and reported on memories that were evoked.
PARTICIPANTS : Local residents aged between @number@ and @number@ years , except for those with poor health , were included.
PARTICIPANTS : Long-stay NH residents with an order for caloric supplementation ( N = @number@ ) .
PARTICIPANTS : Long-stay nursing home residents aged @number@ and older ( @number@ assessments ) .
Participants low in satisfaction showed no valence effect.
Participants made on average @number@ steps daily , @percent@ of them made less than @number@ steps and @percent@ more than @number@ steps a day.
Participants maintained a 14-day diary to record severity of treatment site responses.
Participants maintained aerobic activities , however resistance and balance exercise levels decreased non-significantly.
PARTICIPANTS : Male and female patients aged ≥ @number@ years at baseline with a Mini Mental State Examination ( MMSE ) score < @number@
PARTICIPANTS : Male and female subjects between @number@ and @number@ years of age with mild to moderate AD.
PARTICIPANTS : Male cyclists ( N = @number@ ) aged 21-54 years riding more than @number@ hours per week.
PARTICIPANTS : Male veterans aged ≥70 years ( n = @number@ ) .
Participants matched target locations located directly to the front or 45° to the side relative to the midline using the preferred and non-preferred arms.
PARTICIPANTS / MATERIALS , SETTING , METHODS : A total of @number@ publications and scientific abstracts were identified from the initial search.
PARTICIPANTS / MATERIALS , SETTING , METHODS : Both women with and without diabetes had experienced natural menopause.
PARTICIPANTS / MATERIALS , SETTING , METHODS : Eighty-six women ( @percent@ ) completed at least one cryopreservation cycle.
PARTICIPANTS / MATERIALS , SETTING , METHODS : Measurements of serum testosterone , androstenedione and dehydroepiandrosterone sulfate were performed using liquid chromatography-tandem mass spectrometry.
PARTICIPANTS / MATERIALS , SETTING , METHODS : The FAC Clinic was initiated to provide individual fertility assessment and counselling.
Participants may be healthier than the general population.
PARTICIPANTS : Medical ICU survivors of mechanical ventilation aged @number@ and older ( N = @number@ ) .
PARTICIPANTS : Medicare fee-for-service beneficiaries discharged from @number@ hospitals in @number@ ( N = @number@ ) .
PARTICIPANTS : Medicare recipients @number@ years and older.
PARTICIPANTS : Men aged 60-79 years ( n = @number@ ) .
PARTICIPANTS : Men aged @number@ and older followed an average of @number@ years ( N = @number@ ) .
PARTICIPANTS : Men aged @number@ to @number@ ( N = @number@ ) .
PARTICIPANTS : Men and women aged @number@ and older from the Invecchiare in Chianti study ( N = @number@ ) .
PARTICIPANTS : Men and women born in @number@ ( N = @number@ ) .
PARTICIPANTS : Men and women @number@ years of age ( n = 180 ) .
Participants : Men ( n = @number@ ) aged @number@ to @number@ years from eight European centers.
Participants ' ( N = 100 ) mean age was @number@
Participants ( n = 25 ) completed an online survey to elicit their opinions regarding their perceptions of their observation experiences.
PARTICIPANTS : N = 2 , 817 individuals ( @number@ men and @number@ women ) included in both the SU.VI.MAX and SU.VI.MAX @number@ studies.
PARTICIPANTS : Nationally representative sample of community-dwelling Medicare beneficiaries ( N = 7487 ) aged ≥65 years.
PARTICIPANTS : NH residents aged ≥60 years.
PARTICIPANTS : NIA grantees.
PARTICIPANTS : Nine FPs , who practised in various settings , who chose to attend a focus group on DMCAs.
PARTICIPANTS : Nineteen healthy participants ( @number@ elderly , @number@ young adults ) were recruited from the general public in Singapore.
PARTICIPANTS : Nineteen older ( ≥ @number@ years old ) men and women.
PARTICIPANTS : Nine thousand four hundred forty-seven community-dwelling persons interviewed through the Second Longitudinal Study of Aging ( LSOA II ) .
PARTICIPANTS : Ninety-nine volunteers with OA ( aged @number@ - @number@ years ) completed the study ( @percent@ female ) .
Participants ( N = @number@ aged 25-65 ) completed mobile surveys up to @number@ times daily for @number@ days.
Participants ( N = @number@ ) completed a phone survey.
Participants ( n = @number@ ) completed questionnaires about caregiving status , sociodemographics , global stress , and HRQoL.
Participants ( N = @number@ Mage = @number@ @percent@ women ) were drawn from the Health and Retirement Study.
Participants ( n = @number@ mean age @number@ years ) had undergone natural menopause and were not using hormone therapy.
Participants ( n = @number@ mean age @number@ years ) had undergone natural menopause and were not using hormone therapy.
Participants [ n = @number@ mean age ( range ) = @number@ ( 65-96 ) years ] completed interviewer-administered questionnaires and objective measures of mobility.
Participants ( n = @number@ ) were @number@ years of age and over , from a midsized Southern Brazilian city.
Participants ( n = @number@ ) with normal scores on psychometric and neuropsychological tests and normal values in blood analyses were included.
PARTICIPANTS : Nonagenarians enrolled in the NonaSantfeliu study.
PARTICIPANTS : Nondisabled community-living older men and women aged @number@ and older ( N = @number@ ) .
PARTICIPANTS : Non-institutionalised men and women aged ≥ @number@ years ( in HSE @number@ @number@ men and @number@ women ) .
PARTICIPANTS : No patient participated in the study.
PARTICIPANTS : @number@ ≥65-year old men and women.
PARTICIPANTS : @number@ adults ≥70 years.
PARTICIPANTS : @number@ adults ( @number@ women and @number@ men ) aged @number@ to @number@ years working full-time without CHD at baseline.
PARTICIPANTS : @number@ adults older than @number@ years , from the Falls Unit , with a history of a previous fall in the last year.
PARTICIPANTS : @number@ cannabis-only smokers , @number@ tobacco-only smokers , @number@ tobacco and cannabis smokers and @number@ non-smokers.
PARTICIPANTS : @number@ Chinese adults aged ≥ @number@ years.
PARTICIPANTS : @number@ Chinese immigrants aged ≥45 years and diagnosed with type @number@ diabetes for at least @number@ year.
PARTICIPANTS : @number@ Chinese men and @number@ women aged @number@ years and over in the community.
PARTICIPANTS : @number@ Chinese patients with prior ISS due to athero-thrombotic disease were recruited from the outpatient clinics during @date@ to @date@ .
PARTICIPANTS : @number@ cognitively healthy individuals ( aged 24-83 ) from the Maastricht Aging Study ( 1992-2004 ) .
PARTICIPANTS : @number@ Community-dwelling AD patients , aged @number@ years or older , were included.
PARTICIPANTS : @number@ community-dwelling adults aged 50-79 years.
PARTICIPANTS : @number@ community-dwelling adults aged 70-79.
PARTICIPANTS : @number@ community-dwelling adults aged between @number@ and @number@ years.
Participants : @number@ community-dwelling adults aged @number@ to @number@ years who did not have functional impairment at enrollment.
PARTICIPANTS : @number@ community-dwelling adults ( @percent@ female ) aged @number@ ± @number@ years at baseline.
PARTICIPANTS : @number@ community-dwelling dementia-free adults between @number@ and @number@ years of age.
PARTICIPANTS : @number@ community dwelling elderly subjects , @number@ women and @number@ men , aged 66-78 years.
PARTICIPANTS : @number@ community-dwelling Japanese aged @number@ years or older.
PARTICIPANTS : : @number@ community-dwelling men aged 40-79 years at baseline.
PARTICIPANTS : @number@ community dwelling men and women aged 67-100 years ( mean = 80.2 ) .
PARTICIPANTS : @number@ community-dwelling older adults ( 59-73 years ) .
PARTICIPANTS : @number@ community-dwelling older persons.
PARTICIPANTS : @number@ community-dwelling older women ( mean age @number@ ± @number@ years ) .
PARTICIPANTS : @number@ community-dwelling people aged 70 + without severe cognitive impairment who met the Cardiovascular Health Study frailty definition.
PARTICIPANTS : @number@ community-dwelling people aged @number@ years and older.
PARTICIPANTS : @number@ community-dwelling veterans age ≥55 years and the individual they would choose to make medical decisions on their behalf , interviewed separately.
PARTICIPANTS : @number@ community-dwelling women aged @number@ to @number@ recruited though public meetings aimed at promoting physical activity in postmenopausal women.
PARTICIPANTS : @number@ community-living Chinese elderly who were cognitively intact at baseline.
PARTICIPANTS : @number@ community residents aged @number@ years or older.
PARTICIPANTS : @number@ consecutive elderly hospitalized patients.
PARTICIPANTS : @number@ disease-free women from nested case-control studies within the Nurses ' Health Study with telomere length measured who also completed food frequency questionnaires.
PARTICIPANTS : @number@ elderly individuals from twelve nursing homes , all aged @number@ yrs or over.
PARTICIPANTS : @number@ elderly participants ( age 65-90 years ) .
PARTICIPANTS : @number@ elderly participants ( mean age : @number@ years ) .
PARTICIPANTS : @number@ elderly patients age ≥ @number@ y who were hospitalized in a Geriatric Orthopedic Rehabilitation Department.
PARTICIPANTS : @number@ elderly subjects aged @number@ and older.
PARTICIPANTS : @number@ elderly subjects ( @number@ women , @number@ men ; mean age @number@.0±9.4 years ) .
PARTICIPANTS : @number@ euthymic BD and @number@ HC participants.
PARTICIPANTS : @number@ family members of NH residents who died with advanced dementia.
PARTICIPANTS : @number@ female nurses from @number@ to @number@ and @number@ men from @number@ to @number@ who completed biennial questionnaires.
PARTICIPANTS : @number@ female subjects ( Body Mass Index ( BMI ) 29-39 , aged between 28-42years ) .
PARTICIPANTS : @number@ fit older women attending a biweekly mild fitness program.
PARTICIPANTS : @number@ grandmothers or acquaintances of dietetic students aged @number@ and older.
PARTICIPANTS : @number@ Health care workers from @number@ GHCSs in the interventional group and @number@ health care workers in @number@ GHCSs in the control group.
PARTICIPANTS : @number@ healthy adult patients undergoing surgery for osteoporotic hip fracture were recruited from @date@ to @date@ .
PARTICIPANTS : @number@ healthy subjects ( @number@ women / 43 men ; mean age : @number@.2±19.8 years ) were examined.
PARTICIPANTS : @number@ healthy women aged @number@ - @number@ years ( mean @number@ ± @number@ y ) .
PARTICIPANTS : @number@ healthy young males completed the study.
PARTICIPANTS : @number@ hospitalized patients aged ≥65 years.
PARTICIPANTS : @number@ independent older people ( mean age @number@.8±6.4 years ) who participated in the FIBRA ( Frailty in Brazilian Older People ) study.
PARTICIPANTS : @number@ individuals aged @number@ to @number@ at baseline ( @percent@ women ) .
PARTICIPANTS : @number@ individuals aged @number@ years old or over between @date@ and @date@ .
PARTICIPANTS : @number@ individuals aged @number@ years or older.
PARTICIPANTS : @number@ initially non-demented older adults ( @number@ with eventual incident dementia ) and @number@ patients with AD.
PARTICIPANTS : @number@ inpatients aged @number@ years or older.
PARTICIPANTS : @number@ inpatients ( mean age @number@ @number@ ) discharged from geriatric ward during year @number@ without any exclusion criteria.
PARTICIPANTS : @number@ male Japanese community dwellers aged @number@ to @number@ years.
PARTICIPANTS : @number@ male physicians ≥70 years without a history of cardiovascular disease ( CVD ) .
PARTICIPANTS : @number@ men aged 60-79 years.
PARTICIPANTS : @number@ men and @number@ women aged @number@ years and older.
PARTICIPANTS : @number@ men and women aged 45-69 years randomly selected from the population of two districts of Novosibirsk , Russia.
PARTICIPANTS : @number@ men and women aged @number@ years or older ( mean @number@ standard deviation @number@ ) at recruitment.
PARTICIPANTS : @number@ million women admitted to hospital for delivery.
PARTICIPANTS : @number@ NHs across Germany.
PARTICIPANTS : @number@ non-demented GP patients aged 75-89 years.
PARTICIPANTS : @number@ non-disabled , community-dwelling subjects aged @number@ years or older living in Santiago.
PARTICIPANTS : @number@ non-institutionalised men aged ≥70 years.
PARTICIPANTS : @number@ @number@ beneficiaries , of whom @number@ had a diagnosis of HF and @number@ were eligible to receive cardiac drugs.
PARTICIPANTS : @number@ @number@ individuals @number@ years and older.
PARTICIPANTS : @number@ @number@ @number@ adults aged ≥65 years attending a total of @number@ @number@ @number@ outpatient visits with a general internist during @date@ .
PARTICIPANTS : @number@ older adults , aged 60-92 years.
PARTICIPANTS : @number@ older adults ( mean [ standard deviation ] age : @number@ [ @number@ ] years ; @percent@ women ) .
PARTICIPANTS : @number@ older community-dwelling men ( mean age @number@ years ) who completed in-home PSG from 2003-2005.
PARTICIPANTS : @number@ older veterans ( mean age = 78.9 ± @number@.5y , @percent@ male ) admitted for recuperative care and rehabilitation.
PARTICIPANTS : @number@ old people living in long-term geriatric wards.
PARTICIPANTS : @number@ outpatients , older than @number@ years , admitted to memory clinics.
PARTICIPANTS : @number@ participants aged @number@ and older with a current diagnosis of major depressive disorder.
PARTICIPANTS : @number@ participants aged @number@ years ( 75-79 for Maori ) .
PARTICIPANTS : @number@ participants aged @number@ years and older.
PARTICIPANTS : @number@ participants aged @number@ years and over included between @number@ and @number@ and followed after @number@ @number@ and @number@ years.
PARTICIPANTS : @number@ participants In the MESA Study.
PARTICIPANTS : @number@ participants , mean age @number@ years , who were at risk of cardiovascular disease.
PARTICIPANTS : @number@ patient files at a large Canadian Optometric Clinic.
PARTICIPANTS : @number@ patients , @number@ years and older , with GAD.
PARTICIPANTS : @number@ patients were included in the study.
Participants @number@ people with dementia identified from standardized interviews and diagnostic algorithms.
PARTICIPANTS : @number@ people with stroke and @number@ age-matched healthy controls aged @number@ to @number@ years living in Sydney , Australia.
PARTICIPANTS : @number@ @percent@ AA and @percent@ EA.
PARTICIPANTS : @number@ persons ≥72 years.
PARTICIPANTS : @number@ persons aged 70-79 years at baseline in the Health , Aging , and Body Composition study.
PARTICIPANTS : @number@ persons , @number@ years and older , registered in both SA and the dementia quality register Svedem were included.
PARTICIPANTS : @number@ postmenopausal women ( mean age @number@ SD @number@ ) .
PARTICIPANTS : @number@ post-menopausal women with at least one risk factor for osteoporosis.
PARTICIPANTS : @number@ respondents aged @number@ years and older from @number@ US states in @number@
PARTICIPANTS : @number@ rural women , age 40-69 , with prehypertension who volunteered for lifestyle modification to reduce blood pressure.
PARTICIPANTS : @number@ staff and students.
PARTICIPANTS : @number@ stroke survivors who completed at least the first follow-up at @number@ months after baseline.
PARTICIPANTS : @number@ subjects , aged 65-96 years.
PARTICIPANTS : @number@ subjects aged @number@ examined 2010-2011.
PARTICIPANTS : @number@ subjects aged @number@ years old.
PARTICIPANTS : @number@ subjects ( mean age = 79 , @percent@ female ) assessed between 2008-2013.
PARTICIPANTS : @number@ subjects ( M = @number@ years , range : 61-89 years ) .
PARTICIPANTS : @number@ trial participants and @number@ participants of the cohort study with a mean age of @number@ ( SD @number@ ) years.
PARTICIPANTS : @number@ unrelated Chinese nonagenarians and centenarians ( @percent@ women , mean age @number@ years ) resident in Dujiangyan.
PARTICIPANTS : @number@ US adults aged ≥ @number@ y of the National Health Interview Survey ( @number@ @number@ and 2004-2012 ) .
PARTICIPANTS : @number@ women aged≥69 years.
PARTICIPANTS : @number@ women aged @number@ years or older who recently completed treatment for breast cancer.
PARTICIPANTS : @number@ women and @number@ men aged ≥75 years from the second wave of SHARE.
PARTICIPANTS : @number@ women with chronic mobility impairments who developed early-stage breast cancer prior to age @number@
PARTICIPANTS : @number@ workers from different sectors and socio-professional categories ( @percent@ men and @percent@ women ; @percent@ younger than @number@ years old ) .
Participants < @number@ years old outperformed those ≥ @number@ in both samples.
Participants @number@ years or older who were cognitively normal at baseline were followed up to the outcome of incident MCI.
PARTICIPANTS : Nursing home residents with advanced dementia aged @number@ and older with a 3-day hospitalization ( N = @number@ ) .
PARTICIPANTS : Nursing home residents with advanced dementia and feeding problems and family surrogates ( N = @number@ ) .
PARTICIPANTS : Nursing home residents with palliative care needs.
Participants of all ages preferentially relied on the temporal pattern of events in their inferences , even if this conflicted with statistical information.
Participants of a mass brain function examination were considered as \ "early responders. \ "
Participants of Mexican origin ( n = @number@ ) were members of the Sacramento Area Latino Study on Aging cohort.
PARTICIPANTS : Of @number@ patients recruited , @number@ patients had dementia at baseline.
PARTICIPANTS : Of @number@ total residents aged @number@ years or older , @number@ ( @percent@ ) participated at this study.
Participants often normalized their sleeping problems and had developed a number of coping strategies.
Participants of the D-INT group received usual care.
PARTICIPANTS : Older adult decedents.
PARTICIPANTS : Older adults ( age ≥65 years ) with pre-frailty or frailty defined using the Fried criteria.
PARTICIPANTS : Older adults ( N = 60 ) age > 70 years recruited from the community.
PARTICIPANTS : Older adults ( N = @number@ mean age @number@ ) with stable coronary heart disease recruited between @date@ and @date@ .
PARTICIPANTS : Older adults not wearing hearing aids ( N = @number@ mean age @number@ @percent@ female ) .
PARTICIPANTS : Older adults with dementia over the age of @number@ were recruited.
PARTICIPANTS : Older Medicare fee-for-service beneficiaries.
PARTICIPANTS : Older people aged ≥65 years without care-need certification ( n = 118 ) .
PARTICIPANTS : Older people ( N = 47 , mean age @number@ years ) suffering from polymyalgia rheumatica.
PARTICIPANTS : Older persons without dementia from the Rush Memory and Aging Project ( N = @number@ ) .
Participants older than @number@ years of age demonstrated the highest concentrations of Pb in their blood , tibia , and calcaneus bones.
Participants on ART were more likely to report their HIV-positive status , and participants reporting false-negatives were more likely to have older HIV tests.
PARTICIPANTS : One hundred and eight community-living residents aged 75- @number@ years.
PARTICIPANTS : One hundred and ninety outpatients with cancer during the first @number@ months of follow up in the PF-EC study.
PARTICIPANTS : One hundred and seventy-five malnourished older adults , aged 86±8 years.
PARTICIPANTS : One hundred eighty-eight independently living subjects aged 66-96 years.
PARTICIPANTS : One hundred fifty-five glaucoma patients and @number@ healthy controls.
PARTICIPANTS : One hundred fifty-four middle-aged to older adults ( age 45-77 y ) participated.
PARTICIPANTS : One hundred fifty-three participants ( ages 45-77 years , @percent@ women ) in the population-based Wisconsin Sleep Cohort.
PARTICIPANTS : One hundred fifty-two normal-elderly community volunteers.
PARTICIPANTS : One hundred forty-five participants aged @number@.6±7.2 were recruited using flyers distributed at health fairs , senior centers , and lifelong learning programs.
PARTICIPANTS : One hundred forty-two clients receiving home-based aging services.
PARTICIPANTS : One hundred healthy sleepers aged 19-77 y were selected from a representative population sample by a two-step screening.
PARTICIPANTS : One hundred patients undergoing elective off-pump coronary artery bypass graft surgery.
PARTICIPANTS : One-hundred seventy-four of @number@ ( @percent@ ) FIGS participants agreeing to the home assessment.
PARTICIPANTS : One hundred sixty-nine primary family caregivers of participants in the Aging , Demographics , and Memory Study ( ADAMS ) .
PARTICIPANTS : One hundred thirty older adults aged @number@ years and older with recently remitted major depression.
PARTICIPANTS : One hundred twenty-four community-dwelling Chinese near-centenarians and centenarians.
PARTICIPANTS : One hundred twenty older adults ; men and women aged @number@ years and older.
PARTICIPANTS : One thousand and forty seven ( @number@ @number@ ) non institutionalised subjects aged @number@ or over , hospitalised via ED.
PARTICIPANTS : One thousand and thirty-eight individuals from the Invecchiare in Chianti ( InCHIANTI ) study.
PARTICIPANTS : One thousand eighty-four men and @number@ women aged @number@ and older with complete data on anthropometry , hand-grip strength and self-reported mobility.
PARTICIPANTS : One thousand forty-eight elderly patients hospitalized for acute medical diseases.
PARTICIPANTS : One thousand four hundred forty-five community-based older persons without dementia.
PARTICIPANTS : One thousand one hundred forty urban residents aged @number@ to @number@ years at baseline.
PARTICIPANTS : One thousand seventy-six members of the Rancho Bernardo cohort aged @number@ to @number@ at baseline.
PARTICIPANTS : One thousand two hundred sixty-three women and @number@ men.
PARTICIPANTS : One thousand two hundred thirty-seven male twins aged @number@ to @number@ years.
Participants or their informants reported all medications taken in the @number@ weeks before each study visit.
PARTICIPANTS : Our analysis included @number@ patients among whom @number@ ( @percent@ ) were 75-years-old or more.
PARTICIPANTS : Out of @number@ potential participants , @number@ were included ( mean age @number@.2±4.6 years ) .
PARTICIPANTS : Outpatients with mild hypertension treated with a low dose of amlodipine.
PARTICIPANTS : Overweight and obese women , 45-76 years old.
PARTICIPANTS : Panels of @number@ males and @number@ females followed from adolescence ( 7th-12th grades ) into early adulthood ( ages 18-27 years ) .
PARTICIPANTS : Participants from the Blue Mountains Eye Study ( BMES ) and Rotterdam Study ( RS ) .
PARTICIPANTS : PARTICIPANTS included @number@ healthy males from birth ( cord blood ) to @number@ yr.
PARTICIPANTS : Participants were community-dwelling men aged @number@ to @number@ years who were residing in Perth , Western Australia.
PARTICIPANTS : Participants were diagnosed with dementia , severity ranging from mild to severe , and were recruited from health care and community agencies.
PARTICIPANTS : Participants were inpatients in a hospital setting , including rehabilitation units.
PARTICIPANTS : Participants were @number@ community-dwelling men aged @number@ and older , followed for up to @number@ years.
PARTICIPANTS : Participants were @number@ frail seniors , followed up for four years.
PARTICIPANTS : Participants were @number@ men and @number@ women aged @number@ years or older.
Participants : Participants were @number@ participants accruing @number@ events over @number@ years ' median follow-up.
PARTICIPANTS : Participants were @number@ patients residing in @number@ SLCs.
PARTICIPANTS : Participants were @number@ persons @number@ years and older with type @number@ diabetes from New York City and Upstate New York.
PARTICIPANTS : Participants were recruited from a primary care PMR inception cohort ( n = 654 ) .
PARTICIPANTS : Patients ≥70 years old without delirium at hospital admission who were at intermediate-to-high risk of developing delirium and received usual care only.
PARTICIPANTS : Patients admitted to the GEM units who stayed longer than @number@ days were included in the study.
PARTICIPANTS : Patients aged @number@ or older hospitalized in medical divisions through the emergency department.
PARTICIPANTS : Patients aged @number@ years and older receiving inpatient rehabilitation for a primary diagnosis of TBI between @number@ and @number@
PARTICIPANTS : Patients aged @number@ years or older suffering from cancer presented at the oncogeriatric multidisciplinary meeting.
PARTICIPANTS : Patients enrolled in the ABC Medical Home program between @date@ and @date@ .
PARTICIPANTS : Patients identified as being undernourished or at risk of disease-related malnutrition using the Nutritional Risk Screening tool NRS-2002.
PARTICIPANTS : Patients ( N = 143 , 036 ) with stroke discharged from inpatient rehabilitation during @number@ and @number@
Participants perceived self-compassion for the aging body to be idealistic and contextual.
Participants ' performance on objective pen and paper measures of cognition was compared to performance on subjective online screening measures.
Participants performed a finger pressing task , exerting @percent@ of their maximal force.
Participants performed a MROM assessment and a maximal voluntary contraction of the plantarflexors before and immediately after @number@ min of passive stretching.
Participants performed an object categorization task in three conditions , namely auditory-only ( A ) , visual-only ( V ) , and AVspeech.
Participants performed antiphase coordination of the right and left ankles or shoulders while paced by an auditory metronome.
Participants performed a series of computerized head tracking and cognitive game tasks while standing on fixed and sponge surfaces.
Participants performed a single bout of resistance exercise , followed by biopsies at @number@ and @number@ hours post exercise.
Participants performed a stop-signal task , which included a choice RT block , global stop-signal block , and stimulus-selective stop-signal block.
Participants performed a Stroop task to assess Stroop interference and NP suppression concurrently.
Participants performed a task switching experiment where they switched between emotion and age categorizations among faces.
Participants performed basketball free throws and dart throws as a transfer task under standardized conditions.
Participants performed different mobility and subtraction tasks under both single- and dual-task conditions.
Participants performed faster on Detection , One Card Learning , and One Back at home compared with the clinic.
Participants performed four trials at three initial lean magnitudes and were subsequently classified as single or multiple steppers.
Participants performed @number@ maximal velocity-dependent plantar flexions at a constant load of @percent@ maximal voluntary isometric contraction ( MVC ) .
Participants performed static and dynamic force modulation tasks either with the right and left hand separately or both hands simultaneously.
Participants performed task-switching as the activation task and were cued by the color of the stimulus for the task to be performed in each block.
Participants performed the task at peak alcohol levels.
Participants performed the TUG test in @number@ s ( SD = @number@ s ) .
Participants performed the Wingate Anaerobic Test ( WAnT ) before and after a 13-week CSRT program ( three sessions per week ) .
Participants performed this task in the absence of vision , while executing a discrete RT task.
Participants performed three trials of unobstructed level ground walking and obstacle crossing during walking before and after quadriceps muscle fatigue.
Participants performing in the lower half on the divided attention task qualitatively and quantitatively mirrored the results in MCI patients.
PARTICIPANTS : Persons aged @number@ and older and the individual they identified as most likely to make treatment decisions on their behalf.
PARTICIPANTS : Persons aged @number@ and older free of dementia at baseline ( n = 1 , 225 ) .
PARTICIPANTS : Persons aged @number@ and older recruited from physician offices and a senior center.
PARTICIPANTS : Persons who had experienced cardiac arrest receiving CCR or Std-ALS.
PARTICIPANTS : Persons who participated in the Beaver Dam Eye Study.
Participants ' perspectives were thematically categorized as technology experiences , interactions with coach , training approach , and specific activities.
Participants placed their forearms on a passive motion apparatus which extended the elbow joint at constant velocities between @number@ and @number@.35°s ( @number@ ) .
Participants ' plasma LECT2 levels were measured by an enzyme-linked immunosorbent assay.
PARTICIPANTS : Police officers attending one of five 2-hour trainings ( N = @number@ ) .
PARTICIPANTS : Population aged over @number@ years.
PARTICIPANTS : Population-based sample of @number@ licensed drivers aged @number@ and older.
Participants positive for both instruments were classified as cognitively frail.
Participants positively evaluated most of the processes of the program activities and services.
Participants positively evaluated the content and quality of the video.
Participants practiced a sequence of @number@ monosyllabic nonwords that was retested following nighttime sleep.
Participants preferred the virtual task over the real task.
Participants preferred to turn toward the hemisphere with larger putamen , cerebellum and ( in younger adults only ) hippocampus.
Participants presented with positive profiles across physical , psychosocial , and social environment domains that influence the capacity to be mobile.
Participants provided blood samples and completed the Hot Flash Related Daily Interference Scale at baseline as well as @number@ and @number@ months later.
Participants provided information on healthy lifestyle activities including smoking , alcohol use , diet , exercise , obesity as well as social support.
Participants provided information on self-perceptions of ageing , physical activity , self-rated health , number of chronic conditions and demographics ( T1 ) .
Participants provided self-reported health and demographic information , completed cognitive measures , and had their blood pressure and peak expiratory flow assessed.
Participants provided self-report regarding knee OA pain and underwent a lower extremity functional performance test.
PARTICIPANTS : Purposeful sampling of @number@ family physicians in solo and small and large group practices within the @number@ models of PHC.
Participants randomized to the control group will continue to behave as they did prior to study enrolment.
PARTICIPANTS : Randomly sampled villages were enumerated to identify people aged ≥ @number@ years.
Participants ranged in age from 83-90 years.
Participants ranged in age from @number@ to @number@ with a mean age of @number@
Participants rated a mean of @number@ ( range , 3-24 ) items as \ "essential. \ "
Participants rated each MMD according to text readability , ease of opening , ease of medication removal , transportability and overall rating.
Participants rated items related to benefits highest , followed by side effects.
Participants rated mean improvement after final treatment as 26-50% for wrinkles , 51-75% for pigment , and 51-75% for texture.
Participants rated personal events that were elicited with cue words on reliving or vividness.
Participants rated their likelihood of their accessing online cognitive screening and gave rationales.
Participants rated their memory more harshly on positively than neutrally or negatively worded MSE items.
Participants rated the training quality at @number@ @date@ and the likelihood they would apply new knowledge to their work at @number@ @date@ .
Participants read aloud ambiguous sentences with the goal of clearly communicating one designated meaning.
Participants recalled a memory of an attained and a failed goal and rated the subjective distance between each memory and the present.
Participants recalled an event with the SAI or free recall instructions.
Participants received 60-min individualized training sessions , @number@ times a week for @number@ weeks.
Participants received an initial VD ( Ergocalciferol ; oral solution @number@ @number@ IU / 1.5 ml ) , and followed a VD treatment regime thereafter.
Participants received approximately @number@ hours of computerized speed of processing training.
Participants received a US $ 5 gift card incentive for each month returned.
Participants received comprehensive dementia evaluations including structural MRI , neuropsychological testing , and informant interviews.
Participants received daily calcium ( @number@ mg ) and vitamin D ( @number@ IU ) .
Participants received either incidental ( animacy judgments ) or intentional encoding instructions while fMRI was employed during the encoding of associations and items.
Participants received financial , instrumental , and emotional support , and they actively provided instrumental and emotional support to others and involved in social engagement.
Participants received identical treatments at months @number@ @number@ @number@ @number@ and @number@ and were assessed without treatment at @number@ @number@ and @number@ months.
Participants received one @number@ ml intra-articular injection in the treatment knee and were evaluated at @number@ @number@ @number@ and @number@ weeks post-treatment.
Participants received three treatments : combined RF and intense pulsed light ( IPL ) on one hand and IPL treatment alone on the other.
Participants received trivalent influenza vaccine and donated blood samples before and @number@ to @number@ days after vaccination.
Participants receiving the neutral-mood induction reported comparable levels of subjective age at pre- and postinduction.
Participants receiving the sad-mood induction reported changes toward older felt ages from pre- to postinduction.
Participants regained balance by taking one or more rapid steps.
Participants repetitively lifted a box weighing @number@ kg at a frequency of @number@ lifts / min for a maximum of @number@ min.
Participants reported a low level of sexual desire and sexual enjoyment and moderate levels of sexual arousal and orgasm.
Participants reported a target's presence or absence by either pressing a key or marking on recording sheets.
Participants reported background characteristics representing their resources and measures of needs for each family member.
Participants reported engaging in sustained and routine physical activity , yet some identified a need for additional support to adopt the prescribed health behaviors.
Participants reported experiences of weight discrimination in everyday life and frequency of light , moderate and vigorous physical activities.
Participants reported extreme levels of distress , with only seven ( @percent@ ) scoring less than @number@ on the Distress Thermometer.
Participants reported feeling most adult when with co-workers or romantic partners , and least adult with mothers , fathers , or friends.
Participants reported few side effects.
Participants reported incident falls monthly for @number@.7±1.2 years.
Participants reported lifelong exercise history patterns.
Participants reported needing increased social support , especially emotional support from health care providers , family , and HIV-positive peers.
Participants reported overall health and quality of life , using a five-point scale ( excellent-poor ) .
Participants reported physical ability within three domains : physical effort , stooping / kneeling / crouching , and lifting.
Participants reported prescription medications in a clinical interview.
Participants reported sleep duration in 1998-2000 and 2002-2004 , and all stroke cases were recorded until @date@ .
Participants reported strategy use ( e.g. , rote repetition , imagery ) after each test.
Participants reported that partnerships between organisations are necessary and beneficial within the EMCAC sector.
Participants reported that the community-based singing facilitator was essential to the program's success.
Participants reported that they utilized both emotion-focused and problem-focused strategies , and that many of these were faith-based.
Participants reported their levels of satisfaction with food-related life by completing the SWFL scale , which consists of five items grouped into a single dimension.
Participants reported the time they had spent per week engaging in PA over the last year.
Participants reported they sought NM because it offered a different system of care aligned with their values.
Participants reported using several coping strategies , which we frame as individual approaches to resilience.
Participants reporting memory complaints at baseline were excluded.
Participants responded faster in all dual-task conditions when focusing on RT performance than on balance.
Participants responded to a postal enquiry and underwent femoral BMD densitometry in @number@ ( baseline ) and @number@ ( follow-up ) .
Participants responded to a questionnaire asking about demographic and physical characteristics , frailty criteria , and quality of life.
Participants responded to attended and unattended peripheral targets while we recorded event-related potentials ( ERPs ) to both targets and attention-directing spatial cues.
Participants responded to PM target words embedded in an ongoing lexical decision task ( LDT ) .
Participants responded to questions under the Geriatric Depression Scale , Ecomapa , Genogram and Calgary model.
PARTICIPANTS : Respondents @number@ years and older in @number@ ( n = 18 , 908 ) .
Participants returned @number@ of @number@ calendar months over the 12-month follow-up for @percent@ compliance rate.
Participants returned @number@ week later for a recognition test.
Participants rode an actual bicycle along a virtual roadway.
PARTICIPANTS : Salisbury Eye Evaluation Study participants aged @number@ and older ( N = 2 , 520 ) .
Participants searched a target display for a letter in a specific color and indicated its identity.
Participants self-reported antidepressant use and chronic health conditions.
Participants self-reported emotionally or physically traumatic experiences across the lifespan at a mean age of @number@ years.
Participants self-reported health status , medical and substance use history , and completed behavioral and psychometric health scales.
Participants self reported whether they felt dizzy , light-headed or unsteady on standing.
PARTICIPANTS / SETTING : @number@ adults from the SU.VI.MAX study ( Supplementation with Antioxidant Vitamins and Minerals study ) .
PARTICIPANTS / SETTING : This community-based study included @number@ men and women aged @number@ to @number@ years at baseline.
PARTICIPANTS : Seven hundred and seventy-two participants aged @number@ or above with at least one chronic disease and were living in the community.
PARTICIPANTS : Seven hundred eighty-six individuals with a mean age of @number@ ( range 26-96 ) ( N = @number@ ) .
PARTICIPANTS : Seven hundred eleven older adults ( mean age @number@.2±6.2 , @number@ ( @percent@ ) female and @number@ ( @percent@ ) male ) .
PARTICIPANTS : Seven hundred thirteen women aged @number@ to @number@ participating in the Women's Health and Aging Studies.
PARTICIPANTS : Seven hundred twenty thousand , two hundred ninety-seven adult patients hospitalized in subdural hematoma.
PARTICIPANTS : Seventeen males ( mean age of @number@ years ) reporting prior TBI and @number@ non-TBI ( mean age of @number@ years ) .
PARTICIPANTS : Seventy-four frail elderly individuals , with @number@ subjects in the control group and @number@ subjects in the treatment group.
PARTICIPANTS : Seventy-four glaucoma patients and glaucoma suspects.
PARTICIPANTS : Seventy-two inactive community-dwelling older adults with self-reported sleep and cognitive problems ( mean age @number@ ± @number@ @percent@ women ) .
Participants shared their perceptions of their NP educational preparation and suggestions for enhancing gerontologic curriculum.
Participants showing strong illusory effects in the bisection of long gradients showed analogous effects in the bisection of very short ones.
PARTICIPANTS : Six hundred ten nondemented and nondepressed community-residing adults age @number@ and older.
PARTICIPANTS : Six hundred thirty-nine individuals aged @number@ to @number@ years.
PARTICIPANTS : Six hundred thirty-one adults aged @number@ and older who were at-risk drinkers at baseline , @number@ of whom who completed a 12-month assessment.
PARTICIPANTS : Six hundred twenty-nine adult , on-pump cardiac surgery patients with ScvO2 and arterial lactate obtained on admission to the ICU.
PARTICIPANTS : Sixteen healthy older and @number@ healthy young participants.
PARTICIPANTS : Sixty hypertensive older people , @number@ non-hypertensive older people and @number@ non-hypertensive young people were recruited from June to @date@ .
PARTICIPANTS : Sixty-nine elderly subjects ( @number@ men and @number@ women ) aged @number@ and older.
PARTICIPANTS : Sixty-seven subjects in @number@ cohorts , one starting at age @number@ and one starting at age @number@ years.
PARTICIPANTS : Sixty-two elder nursing home residents participated in face-to-face interviews.
Participants ' social network was then assessed by the Social Convoy Questionnaire twice over a 2-year period.
PARTICIPANTS : Staff in any role with resident contact ( n = 497 ) .
Participants stepped over a stationary , visible obstacle on a walkway.
Participants stood comfortably and then walked at a self-selected pace for @number@.2m.
Participants stood on the active plate and inactive plate for WBVT and sham interventions , respectively.
Participants studied faces and were either presented with the age or first had to guess before being shown the correct age.
Participants studied words paired with point values , and \ "bet \ " on whether they could later recall each word.
PARTICIPANTS : Studies including adults and older adults without a dementia diagnosis were included.
PARTICIPANTS : Study 1 : @number@ older ( 65 + years , adequate cognition ) medical or surgical patients.
PARTICIPANTS : Study participants included @number@ men and @number@ women.
PARTICIPANTS : Study subjects were selected from the schools of Delhi.
Participants subsequently filled out scales assessing aging anxieties , and ageist and compassionate attitudes.
Participants subsequently returned to the laboratory for assessment of endogenous pain facilitation using a mechanical temporal summation protocol.
Participants tended to perceive the robot as easier to use after performing the PST with it.
PARTICIPANTS : Ten healthy , untrained female volunteers participated in this study.
Participants that subsequent to task administration reported awareness of the study-test relationship obtained higher priming scores.
PARTICIPANTS : The 9-wk healthy aging MBI was developed for participants aged @number@ y and older.
PARTICIPANTS : The baseline sample included @number@ dementia caregivers.
PARTICIPANTS : The exposed group was @number@ patients who had worn an accelerometer daily during their rehabilitation stay.
Participants , their study partners ( generally carers ) , and all assessors were masked to treatment assignment throughout the study.
Participants then attended three test sessions at their habitual lunch time.
Participants then completed @number@ or @number@ tasks to select suitable long-term care facilities for the person described.
Participants then completed @number@ weeks of open-label sertraline.
Participants then reported their daily progress and experiences of support and hindrance toward that goal over a 100-day study period.
Participants then re-told this narrative as a text message.
PARTICIPANTS : There were @number@ female patients aged @number@ years or older included in the analysis.
PARTICIPANTS : There were @number@ ( @number@ male , @number@ female ) community-dwelling older people aged @number@ and older.
PARTICIPANTS : There were @number@ participants ( @percent@ men ) aged @number@ to @number@ years at baseline assessment and free of diabetes.
PARTICIPANTS : There were @number@ patients with ACS who were consecutively recruited.
PARTICIPANTS : The sample comprised @number@ veterans aged 50 + years who received a new diagnosis of PTSD between fiscal years 2008-2011.
PARTICIPANTS : The sample was composed of @number@ socioeconomically diverse African-American and white adults who resided in Baltimore , MD.
PARTICIPANTS : The study cohort consisted of elderly ( > 65 years old ) @number@ patients that had presented to the geriatric clinic.
PARTICIPANTS : The study group consisted of @number@ subjects , aged 71-88 years.
PARTICIPANTS : The study included @number@ frail elderly patients , aged ≥75 years , in need of acute in-hospital treatment.
PARTICIPANTS : The study included outpatients aged ≥ @number@ years with chronic , non-cancer , non-ischemic pain in the back , joints , or limbs.
PARTICIPANTS : The study population included people whose injuries occurred from @number@ to @number@ ( N = 45 , 442 ) .
PARTICIPANTS : The study sample had @number@ women and @number@ men.
PARTICIPANTS : Thirteen Washington State VR counselors and @number@ individuals , @number@ to @number@ years old , with MS , MD , LEP or SCI.
PARTICIPANTS : Thirty-nine inpatients with PEG feeding were assessed for plasma arginine.
PARTICIPANTS : Thirty older adults with cardiovascular risk factors.
PARTICIPANTS : Thirty-one veterans age @number@ years and older and their surrogates.
PARTICIPANTS : Thirty-three patients from @number@ pedigrees with DOA harboring heterozygous mutations in the OPA1 gene and @number@ healthy subjects were enrolled.
PARTICIPANTS : Three hundred and fifty-seven community-dwelling adults aged @number@ and older.
PARTICIPANTS : three hundred and thirty-two older adults ( mean age = @number@ ± @number@ years ) .
PARTICIPANTS : Three hundred fifty-two acute medical patients aged @number@ and older who were continent before admission.
PARTICIPANTS : Three hundred seven community-dwelling women aged @number@ to @number@ at study baseline.
PARTICIPANTS : Three hundred seventy-eight adults aged @number@ years or older undergoing in-home aging services care management assessments.
PARTICIPANTS : Three hundred sixty-nine women from the Women's Health and Aging Study II aged 70-79 years , free of frailty at baseline.
PARTICIPANTS : Three hundred sixty-seven adults age @number@ y and older , with osteoarthritis pain and insomnia symptoms.
PARTICIPANTS : Three hundred twenty-three NH residents with advanced dementia and their HCPs.
PARTICIPANTS : Three thousand fifty-five community-dwelling older adults , both blacks and whites , at year @number@
PARTICIPANTS : Three thousand seventy-five participants : mean age @number@ @percent@ Caucasian , @percent@ female , @percent@ taking ACE-Is , @number@ years of follow-up.
PARTICIPANTS : Three thousand two hundred fifty-six people aged @number@ years and older at baseline.
PARTICIPANTS : Three thousand two hundred nineteen community-dwelling European men aged @number@ to @number@
PARTICIPANTS : TILDA consists of a sample of @number@ individuals aged @number@ years and older who were representative of the Irish population.
PARTICIPANTS : To examine temporal trends , @number@ Medicare admissions in @number@ to @number@ at @number@ U.S. hospitals were used.
Participants took part in semi-structured interviews , which were transcribed and underwent thematic content analysis.
PARTICIPANTS : Total sample N = 73 ; persons with multiple sclerosis ( PwMS ) n = 52 ; healthy controls n = 21.
Participants trained three times per week for @number@ weeks.
PARTICIPANTS : Twenty-four male and female healthy participants , aged @number@.0±5.8 years.
PARTICIPANTS : Twenty-four male and female healthy participants , aged @number@.0±5.8 years.
PARTICIPANTS : Twenty-nine healthy women ( mean @number@ y ) .
PARTICIPANTS : Twenty residents with confirmed dementia diagnosis were recruited from two care homes that specialised in dementia care.
PARTICIPANTS : Twenty-two older female adults aged @number@ to @number@ with postprandial hypotension.
PARTICIPANTS : Two hundred and thirty one ( @percent@ women ; median age range of 57-63 ) older African Americans.
PARTICIPANTS : Two hundred ninety nine consecutive outpatients undergoing screening colonoscopy.
PARTICIPANTS : Two hundred thirty-one elderly Medicare recipients ( aged > or = 65 years ) residing in northern Manhattan , New York.
PARTICIPANTS : Two thousand eight hundred ninety community-dwelling citizens aged @number@ to @number@ at baseline and surviving at least @number@ years.
PARTICIPANTS : Two thousand forty-nine well-functioning adults ( mean age @number@ @percent@ black ) .
PARTICIPANTS : Two thousand four hundred and forty three community-dwelling older Chinese aged from @number@ to @number@ years were recruited.
PARTICIPANTS : Two thousand three hundred seventy-five Chinese Singaporeans aged @number@ and above without dementia and degenerative disorders.
Participants typically did not have just one chronic condition , CKD , but a number of commonly co-occurring conditions.
Participants underwent a clinical examination including diagnosis of somatic disorders , and a structured interview including questions about sociodemographic and social factors.
Participants underwent a complete blood count evaluation and a structured questionnaire , used to collect epidemiological data.
Participants underwent a comprehensive geriatric assessment ( CGA ) at baseline , and final assessments were either in person or via mailed survey.
Participants underwent a comprehensive geriatric assessment including frailty status evaluated by means of the study of osteoporotic fractures ( SOF ) criteria.
Participants underwent a detailed interview and laboratory investigations that included estimation of nonfasting serum glucose , glycosylated hemoglobin , and lipid profile.
Participants underwent a neuropsychological battery and had repeated testing ( mean time span @number@ ± @number@ years ) .
Participants underwent anodal ( 30min , @number@ mA , LPPC ) and sham tDCS.
Participants underwent assessment of balance , dual-tasking , endurance , gait , and vision-related QOL.
Participants underwent a standardised clinical assessment and neuropsychological battery.
Participants underwent blood and urine tests , including serum lithium concentrations.
Participants underwent cardiac MRI including tissue tagging and 31P spectroscopy and exercise testing with noninvasive central hemodynamic measurements.
PARTICIPANTS underwent cognitive screening using the Community Screening Interview for Dementia ( CSI-D ) and the Five-Word Test.
Participants underwent determination of circulating UA levels and comprehensive geriatric assessment.
Participants underwent diffusion tensor imaging , provided blood samples , and participated in a health evaluation.
Participants underwent fMRI scanning during picture encoding , and multivariate analysis was used to characterize the relationship between network activations and recognition.
Participants underwent high-resolution structural imaging for assessment of GM volume and diffusion tensor imaging ( DTI ) for assessment of WM integrity.
Participants underwent lung function and laboratory testing , including measurement of sCysC levels.
Participants underwent magnetic resonance imaging to quantify total gray matter and subcortical gray matter volume.
Participants underwent @number@ successive brain magnetic resonance imaging scans , first at baseline and the then after a mean follow-up of @number@ months.
Participants underwent QST and a @number@ Tesla proton magnetic resonance spectroscopy.
Participants underwent quantitative sensory testing , including measures of pain sensitivity and facilitation at the knee , and pain inhibition.
Participants underwent repeat assessment using either parallel or alternate forms at follow-up.
Participants underwent routine clinical and instrumental diagnostic assessment.
Participants underwent supplementary cognitive testing , blood sampling and MRI including measurements of regional and global CBF.
Participants underwent uniform neuropathologic evaluations , including TDP-43 cytoplasmic inclusions.
Participants underwent up to four sessions of treatment with subdermal minimal surgery technology at 4-week intervals.
Participants underwent walking assessments and TCD ultrasonography measures of MCA ΔCBF during the n-back task of executive function.
PARTICIPANTS : Urban and rural community-dwelling people aged @number@ and older at baseline.
Participants used SenseCam to prospectively sample events from a typical week , which they recalled two weeks later.
Participants used the CGM system at home and in the clinic.
PARTICIPANTS : US physicians.
PARTICIPANTS : U.S. representative sample of adults aged @number@ years and older ( N = @number@ ) from five ethnic / racial groups.
Participants utilized @number@ decision matrices , which varied in complexity , regarding a consumer purchase.
PARTICIPANTS : VACS is a prospectively enrolled cohort study of HIV-infected patients and age- , race- and site-matched HIV uninfected patients.
PARTICIPANTS : Veterans aged @number@ and older enrolled in VACS from @number@ to @number@ ( N = @number@ ) .
PARTICIPANTS : Veterans aged ≥ @number@ years with Alzheimer's or related dementia diagnosis after @number@ with minimum of one-year follow-up or death were included.
Participants viewed 50 / 50 superimposed face / place images and judged whether the faces were male or female , rendering places perceptible but task-irrelevant.
Participants viewed and discussed videos that modeled the targeted communication behaviors for older adult patients interacting with physicians.
Participants viewed @number@ slides including pairings of a happy face with each of the negative emotions.
Participants viewed potential uses for wellness tools with regard to their health and health information positively , as they felt currently available tools were lacking.
Participants viewed the film followed the next day by misinformation presented in a postevent summary.
Participants ' views on causes of sexual dysfunction identified biological , psychosocial and spiritual factors.
PARTICIPANTS : Volunteer sample including participants from screenings , chemoprevention , and / or biomarker studies.
Participants walked 533 + / -75 m in the six-minute walking test.
Participants walked on a treadmill at their self-selected comfortable speed in each testing condition.
Participants walked on the treadmill at two different conditions : normal gait and apprehensive gait.
PARTICIPANTS : We analyzed data of @number@ older Chinese adults aged @number@ and above in the Singapore Longitudinal Aging Study-I.
PARTICIPANTS : We examined @number@ male volunteers aged 20-87 years.
PARTICIPANTS : We included @number@ older adults ( @number@ with LLD and @number@ comparison participants ) in this study.
PARTICIPANTS : We included @number@ participants in the analysis.
PARTICIPANTS : We included @number@ subjects of Chinese origin from an ongoing population-based study.
PARTICIPANTS : We included patients from a quality improvement trial aimed at reducing hospital readmissions among patients discharged to SNFs.
PARTICIPANTS : Well-functioning adults aged @number@ to @number@ who participated in the Health , Aging and Body Composition Study.
Participants were administered an extensive battery of demographic , psychosocial , and neuropsychological measures at baseline.
Participants were administered : CogState computerized neurocognitive battery , Prospective Retrospective Memory Questionnaire , personality and meaning-in-life measures.
Participants were administered heavy water ( ²H₂O ; deuterium oxide ) continuously for @number@ wk to isotopically label newly synthesized skeletal muscle proteins and DNA.
Participants were administered self-referent metacognitive efficiency , subjective wellness and depression measures.
Participants were administered the Mini-Mental State Examination ( MMSE ) and the Repeatable Battery for the Assessment of Neuropsychological Status.
Participants were African American women over the age of @number@ in a low-income housing residence.
Participants were aged 40-65years and had T2DM that was not treated with insulin.
Participants were aged 50-88 at the first of six waves of testing covering a 19-year follow-up period ; @percent@ participated in at least three waves.
Participants were aged ≥ @number@ years ( n = @number@ ) .
Participants were a group of undergraduate students and a group of older volunteers ( > @number@ ) .
Participants were aircraft pilots ( N = @number@ ) aged 40-77.9.
Participants were all deemed healthy by medical history , echocardiography , exercise test , spirometry , blood tests , and electrocardiogram.
Participants were all of European descent.
Participants were also asked for their opinions regarding the program's quality and appeal.
Participants were also asked if they experienced any difficulty in performing functional tasks.
Participants were also asked to describe any ethical concerns they had about life extension , if they had any at all.
Participants were also asked to perform tasks in chair stand , tandem stand , and timed walk.
Participants were also prompted to record any additional situations in which they experienced anxiety.
Participants were also screened using three cognitive instruments.
Participants were a mean ( SD ) age of @number@ ( @number@ ) years , and @percent@ women.
Participants were apolipoprotein E ( APOE ) ε3 / ε3 homozygotes with amnestic mild cognitive impairment ( aMCI ) .
Participants were ascertained at multiple university-associated medical centers and clinics across the United States and Sweden by study-specific sampling methods.
Participants were asked about a range of allied health services including dietetic services , public health nurse visits , chiropody and home help.
Participants were asked about difficulties with mobility or other everyday activities.
Participants were asked about previous exposure to , or intent to participate in , the interventions.
Participants were asked about their experience with menopause and vaginal atrophy , including use of non-prescription treatments and their interactions with health-care providers.
Participants were asked a series of questions designed to explore usability concerns and level of satisfaction regarding the device use and subjective efficacy.
Participants were asked how often they felt lonely , with answers dichotomized to never versus rarely / often / very often.
Participants were asked how they would seek help for a character in a vignette with dementia and what aged care services they would use.
Participants were asked to cross simulated streets of varying difficulty while either undistracted , listening to music , or conversing on a cell phone.
Participants were asked to estimate the prevalence of these conditions and to identify their source ( s ) of knowledge.
Participants were asked to maintain constant force output in the absence of visual feedback.
Participants were asked to name two objects as well as the US President and Vice President.
Participants were asked to reproduce the temporal sequence by placing numbered circles ( @number@ to @number@ ) on the arms of the eight-arm maze.
Participants were asked to \ "Tell the story of your hearing. \ "
Participants were asked to use an anonymous survey evaluation form featuring both quantitative and qualitative questions to rate the seminar.
Participants were asked to walk to a target located 8m ahead.
Participants were assessed about food frequency , healthy food knowledge , and the game's interest.
Participants were assessed at baseline ( 2004-2006 ) and @number@ years later ( 2007-2009 ) .
Participants were assessed at baseline and 3- and 6-month follow-up for glycemic and periodontal status.
Participants were assessed at baseline and after @number@ months of training ( or an equivalent delay ) .
Participants were assessed at baseline and end-of-study using clinical and cognitive assessments.
Participants were assessed at baseline , @number@ months , and @number@ months.
Participants were assessed at day @number@ those with glabellar severity of none to mild remained in the study.
Participants were assessed both after @number@ and @number@ months.
Participants were assessed by direct interview to detect low mood.
Participants were assessed clinically , agreed to interviews focusing on stressful life events and social support , and underwent a battery of neuropsychological tests annually.
Participants were assessed for clinically diagnosed MCI and dementia as well as psychometric test-based MCI ( MCI-TB ) at @number@ years of follow-up.
Participants were assessed in terms of their medication use , cognitive status , lower extremity pathology and pain and the activity of climbing the stairs.
Participants were assessed using the Geriatric Depression Scale , the Cognitive Abilities Screening Instrument Chinese version , and the Wechsler Digit Span Task test.
Participants were assessed with a series of clinical examinations and neuropsychological measures.
Participants were assigned to @number@ groups using a nonprobability static group assignment based on their age.
Participants were assigned to Tango or FallProof to complete twenty , 90-min lessons within @number@ weeks.
Participants were assigned to three pain groups according to nCMSP.
Participants were a subset of the Mayo Clinic Study of Aging ( median age @number@ years ) who had undergone magnetic resonance imaging.
Participants were balancing empowerment and a dubious perception of the home care assistants ' knowledge of medicine and safety.
Participants were born in @number@ and most completed a mental ability test at the age of @number@ years.
Participants were categorized according to this score as having either less or more negative diabetes-related quality of life.
Participants were categorized by gender , age , BMI , and left and right foot respectively to compare foot morphology differences.
Participants were categorized by quartile of neighborhood score with a higher quartile representing relative neighborhood advantage.
Participants were categorized in terms of noise exposure , age , and race.
Participants were categorized into two groups according to the estimated day-to-day precision of the doubly-labeled water technique.
Participants were categorized into two groups-sedentary and active ( those getting Centers for Disease Control-recommended daily amount of activity ) .
Participants were chosen after applying the Lyubomirski scale – those who fell into the “happy” category were invited to a semi-structured interview.
Participants were classified according to a modified Unified Parkinson's Disease Rating Scale ( mUPDRS ) score.
Participants were classified according to their level of concern about falling using the Falls Efficacy Scale International ( FES-I ) .
Participants were classified as non-completers ( 439 / 898 , @percent@ ) if they did not complete the Web-based intervention.
Participants were classified as US-born or foreign-born based on self-reported birth country.
Participants were classified in accordance with clinical categories of thyroid function.
Participants were classified into two groups based on whether they had previously experienced suicidal thoughts.
Participants were cluster randomized by room to receive the mHELP or usual care.
Participants were community-dwelling Chinese adults aged 60 + ( Human longevity is influenced by environment and nutrition.
Participants were community-dwelling women aged @number@ or older able to go outside home without assistance.
Participants were compared according to their survival status ( subjects who reached @number@ compared to those who did not ) .
Participants were contacted every @number@ months for @number@ ± @number@ years to ascertain incident falls and fractures , the latter being confirmed by radiographic reports.
Participants were contacted every year thereafter by mail.
Participants were contacted via the Dutch Prader-Willi Parent Association and through physicians specialized in persons with ID.
Participants were continuously monitored in the laboratory.
Participants were debriefed later.
Participants were divided according to MNA ( ≤ @number@ and > @number@ ) .
Participants were divided according to the number of vertebral fractures ( single or multiple fractures ) .
Participants were divided into age groups of 5-year intervals.
Participants were divided into four categories according to change in FOF between the @number@ and @number@ surveys.
Participants were divided into no , mild , moderate , and severe cognitive impairment according to their baseline Mini-Mental State Examination ( MMSE ) score.
Participants were divided into @number@ groups of adherence to MeDi ( low , middle , and high tertiles ) .
Participants were divided into subgroups based on their decade of life , and into subgroups of ≥65 or < 65 years.
Participants were divided into three age groups : @number@ to @number@ years , @number@ to @number@ years , and ≥61 years.
Participants were divided into two groups according to @number@ criteria of International Diabetes Federation.
Participants were divided into two groups based on scores from the Montreal Cognitive Assessment ( MoCA ) , a brief screening tool for MCI.
Participants were drawn from a larger cohort of community-dwelling older people.
Participants were evaluated @number@ @number@ @number@ @number@ and @number@ days posttreatment.
Participants were evaluated using a short battery of physical performance tests to assess their physical performance.
Participants were evaluated while viewing a virtual corridor in a helmet-mounted display.
Participants were excluded if they exhibited performance outside the normal limits of interocular differences or HRindex values , or signs of ocular disease.
Participants were excluded if they reported physical or neurological conditions that limited performance.
Participants were excluded if they were on immunosuppressive treatment and / or had a disease with a clear immunologic ( e.g. , cancer ) component.
Participants were exposed to two conditions : known dry walking ( baseline ) and an unexpected slip initiated when stepping onto a glycerol-contaminated floor.
Participants were far more reluctant to share a room with that resident than to share common spaces.
Participants were followed annually for incident stroke.
Participants were followed annually for up to @number@ visits.
Participants were followed annually for up to @number@ years.
Participants were followed for an average of @number@ years ( SD = @number@ ) .
Participants were followed for @number@ years after audiometric examination.
Participants were followed from date of blood draw for biomarker assays ( baseline ) until death or @date@ .
Participants were followed over four years from their first available visit.
Participants were followed over @number@ months.
Participants were followed until @number@ for mortality and disability.
Participants were followed-up by weekly telephone calls for up to six months.
Participants were followed up for @number@ and @number@ years for falls leading to hospitalization or outpatient care.
Participants were followed up for @number@ years , with biannual visits including neurologic , cognitive , and gait assessments.
Participants were followed up for one year , with monitoring at 3- , 6- , 9- and 12-months.
Participants were followed-up seven years later.
Participants were followed upwards of @number@ years.
Participants were followed , with serial measures , up to @number@ visits and @number@ years ( @number@ total samples ) .
Participants were free of dementia at baseline , and incidence was determined in @number@ ( @percent@ ) cases over @number@ to @number@ follow-up years.
Participants were frequently in different stages for different behaviors.
Participants were from community and seniors centres and retirement homes.
Participants were from the Baltimore Longitudinal Study of Aging ( BLSA ) and submitted multiple 24-hour urine samples over an average interval of @time@ .
Participants were further grouped into MCI subtypes.
Participants were genotyped for @number@ @number@ DNA sequence variants ( @number@ @number@ in exons ) across the genome.
Participants were given two rounds of experience , with different materials , in a situation that produced PI.
Participants were grouped as non-frail , pre-frail , and frail , and categorized as anorexic or not using questionnaire cutoff scores.
Participants were grouped into Optimal ( n = 25 ) vs. Typical ( n = 100 ) performers using performance on @number@ challenging memory measures.
Participants were included consecutively , during July and @date@ .
Participants were initially randomized to a DVD-delivered exercise intervention or an attentional control condition.
Participants were instructed to attempt to recover balance by taking a single step.
Participants were instructed to complete a series of single-solution word fragments as quickly as possible.
Participants were instructed to first relive a personal memory that was characterized by either anger or sadness and to subsequently think aloud about this memory.
Participants were instructed to focus on either their balance or their RT performance , depending on the testing session.
Participants were instructed to make their recognition decision on either the picture or word and to ignore the distracting stimulus.
Participants were instructed to perform at least @number@ treatments a week , for one month.
Participants were instructed to play a computer game with the tongue using TDS.
Participants were instructed to reappraise , suppress , or given no instructions while recalling a negative memory about their romantic relationship.
Participants were instructed to stand as still as possible while verbally responding as fast as possible to the auditory cues.
Participants were instructed to walk at their preferred speed until the end of the pathway and to avoid the obstacle when it was present.
Participants were interviewed by trained investigators to complete a validated structural questionnaire.
Participants were interviewed regarding use of dietary supplements and antacids during the 30-day period preceding enrollment.
Participants were interviewed , went through examination , and had blood samples taken.
Participants were interviewed with the Mini-Mental State Examination ( MMSE ) during their regular scheduled visit.
Participants were invited to undergo brain magnetic resonance imaging ( MRI ) .
Participants were monitored for fatal and nonfatal vascular events.
Participants were more likely to be taking psychotropic medication if they were younger and white.
Participants were not frail at baseline , based on our definition adapted from the Canadian Study for Health and Aging Clinical Frailty Scale.
Participants were @number@ adults aged about @number@ years in the Lothian Birth Cohort @number@ Study , on whom there are IQ data from age @number@
Participants were @number@ adults aged from @number@ to @number@ years.
Participants were @number@ adults aged @number@ years ( @number@ men and @number@ women ) .
Participants were @number@ adults in a Trinidadian lifespan sample.
Participants were @number@ bereaved and @number@ age- and sex-matched non-bereaved controls all aged 65 + years.
Participants were @number@ boys and @number@ girls aged 8-18 years.
Participants were @number@ certified nursing assistants and @number@ homecare workers.
Participants were @number@ CNAs who had experienced recent resident death.
Participants were @number@ community organizations and @number@ staff of community organizations in Baltimore , Maryland.
Participants were @number@ deceased persons from two clinical-pathologic studies.
Participants were @number@ elderly patients with CAD.
Participants were @number@ elderly women ( @number@ ± @number@ years ) recruited from four social and healthcare centers.
Participants were @number@ healthy adults , distributed continuously across @number@ to @number@ years of age.
Participants were @number@ healthy women aged 40-79 years at baseline ( @number@ ) .
Participants were @number@ HIV-infected men and women 50-plus years of age living in New York City , Cincinnati , OH , and Columbus , OH.
Participants were @number@ individuals aged > 70 in the Einstein Aging Study.
Participants were @number@ individuals free of any retinal ocular disease.
Participants were @number@ individuals who completed at least three annual evaluations at one of @number@ past and present Alzheimer's Disease Centers throughout the United States.
Participants were @number@ individuals working in medium-sized public service units.
Participants were @number@ Iranian middle-aged women ( 40-65 years ) .
Participants were @number@ Japanese ( M age = @number@ yr. , SD = @number@ ) .
Participants were @number@ neurological patients with different diagnoses and a community-dwelling sample of @number@ middle-aged and older controls.
Participants were @number@ non-demented older adults.
Participants were @number@ ( @number@ men and @number@ women ) aged @number@ years and over.
Participants were @number@ nursing home residents aged @number@ and older , diagnosed with dementia.
Participants were @number@ nursing home residents aged ≥ @number@ diagnosed with dementia.
Participants were @number@ nursing home residents from @number@ nursing homes in Israel , diagnosed with dementia.
Participants were @number@ older people , dependent in ADL , living in residential care facilities , @number@ ( @percent@ ) of whom had diagnosed dementia.
Participants were @number@ older persons aged at least @number@ years without current treatment for depression and a Mini-Mental State Examination score of at least @number@
Participants were @number@ patients with mean age @number@ years.
Participants were @number@ seniors , with a mean age of @number@ years , @percent@ female , with poor socio-economic conditions.
Participants were @number@ to 19years old and underwent diffusion tensor imaging ( DTI ) and functional magnetic resonance imaging ( fMRI ) .
Participants were @number@ years and older , HIV positive , and diverse in terms of race / ethnicity , gender , and sexual orientation.
Participants were @number@ years or older and community dwelling : @number@ control subjects , @number@ aMCI patients and @number@ AD patients.
Participants were older adults ( ≥70 years ) without dementia who underwent preoperative MRI and elective surgery.
Participants were older adults who were either nonanxious or diagnosed with generalized anxiety disorder.
Participants were older people aged ≥65 years ( n = 118 ) .
Participants were originally recruited in @number@ through elementary schools in a middle-sized Finnish city.
Participants were patients aged ≥18 y admitted to medical and surgical wards.
Participants were patients enrolled in the respective cohorts and trials.
Participants were people aged @number@ and older , community-dwelling , and nondemented at study enrollment , who died during follow-up and underwent autopsy.
Participants were @percent@ white , @percent@ black , @percent@ Hispanic / Latino and @percent@ Asian race / ethnicity.
Participants were predominantly minority with nearly equal numbers of men and women.
Participants were predominantly white / Caucasian ( n = 18 , @percent@ ) with one black / African-American ( @percent@ ) .
Participants were presented with @number@ common odors with intentional encoding instructions that were followed by a yes-no recognition test.
Participants were presented with several tools assessing psychological well-being , lifestyle , social desirability , religiosity and subjective physical health.
Participants were presented with three different visualizations from a wellness pilot study.
Participants were presented with video clips of approaching vehicles , and were either required to indicate a crossing decision , or to estimate TTA.
Participants were provided with the tested device together with a user manual and treatment diary , to perform independent treatments at home for @number@ weeks.
Participants were randomized into an active grape formulation arm or a placebo arm which consumed a formulation free of polyphenols for six months.
Participants were randomized to a 12-month PA intervention versus a successful aging education group.
Participants were randomized to a Mediterranean diet supplemented with extra virgin olive oil , a Mediterranean diet supplemented with nuts , or a control diet.
Participants were randomized to an ILI targeted to weight loss or a diabetes support and education ( DSE ) control group.
Participants were randomized to either CCBT ( n = @number@ ) or RCBT ( n = @number@ ) .
Participants were randomized to either discontinue or continue statin therapy and were monitored monthly for up to @number@ year.
Participants were randomized to @number@ of @number@ interventions : PA , WL + PA , or a successful aging ( SA ) education control arm.
Participants were randomized to @number@ of @number@ treatment groups : PT , ST , or wait-list control.
Participants were randomly assigned to a computer-based cognitive training intervention or measurement-only control.
Participants were randomly assigned to either a group ingesting supplement containing @number@ g black soy peptides daily or a placebo group for @number@ weeks.
Participants were randomly assigned to @number@ weeks of daily transdermal gel that contained @number@ g of testosterone or placebo.
Participants were randomly assigned to two 10-day conditions ( anatabine and placebo ) separated by a 2-4 week washout period.
Participants were randomly assigned to two homogeneous subgroups.
Participants were reassessed after @number@ months.
Participants were recommended to exercise unsupervised at home for a minimum of three 20-minute sessions per week over the 12-week study period.
Participants were recruited from a continuing care retirement community and community centers in the surrounding area.
Participants were recruited from a hospital-affiliated bone clinic.
Participants were recruited from @date@ , through @date@ , with the final follow-up visit by @date@ .
Participants were recruited from February to @date@ .
Participants were recruited from John P. Hussman Institute for Human Genomics , Case Western Reserve University , and Columbia University.
Participants were recruited from the community to visit the TRIL clinic at St James's Hospital , where they underwent a structured medical and psychosocial assessment.
Participants were recruited from the longitudinal Women's Interagency HIV Study ( WIHS ) participant pool.
Participants were recruited from the pediatric hematology / oncology centers at two public hospitals.
Participants were recruited through mainstream and lesbian , gay and bisexual media and venues.
Participants were recruited using a random stratified cluster sampling design with oversampling of adults older than @number@ years.
Participants were recruited using maximum variation sampling based on age , sex and joint replaced ( hip or knee ) .
Participants were re-examined with the same protocol after exactly @number@ and @number@ months.
Participants were required to complete a self-assessed test of cognition , the Test Your Memory questionnaire.
Participants were required to concentrate on detection of passive arm motion and press a trigger held in their left hand once they sensed it.
Participants were required to have a caregiver to complete assessments , access to a telephone , and be able to understand English.
Participants were required to identify previously learned scenes among new ones.
Participants were required to relate meanings to a lexically ambiguous target ( homonym ) .
Participants were required to remember two or four simple colored shapes , while color was used as the relevant dimension.
Participants were satisfied.
Participants were scanned during encoding and the first test.
Participants were scanned while performing easy and hard versions of spatial and temporal context memory tasks.
Participants were seated on a dynamometer with their trunks 30° anteflexed , and they repeated all tests after 1-2 days and @number@ weeks.
Participants were sedentary adults aged @number@ to @number@ years who were at risk for mobility disability but able to walk @number@ m.
Participants were separated into @number@ groups based on tertiles of stride time variability ( i.e. , < 2.0% ; @number@.0-2.8% ; > 2.8% ) .
Participants were six licensed AT practitioners and seven healthy age-matched controls between the ages of 61-76.
Participants were sixty drivers aged @number@ and above ( mean = 76.7 years , @percent@ men ) with no diagnosed neurological disorder.
Participants were stratified by age.
Participants were stratified by age , and interviews occurred only after written informed consent was obtained.
Participants were tested at baseline ( T0 ) and at 6-year ( T2 ) and 12-year follow-up ( T4 ) .
Participants were tested in a sitting position on two occasions , @number@ week apart.
Participants were then prospectively followed up for falls for @number@ months.
Participants were told to maximize their point score and were told their score at the end of each list.
Participants were tracked for @number@ years.
Participants were treated in a 4-week open-label study with YGS at an average daily dose of @number@ ± @number@ g ( @number@.5-7.5 g ) .
Participants were treated with combination antiretroviral therapy for at least @number@ year and had suppressed plasma HIV viral load.
Participants were unselected for face recognition ability ; most were university educated.
Participants : We studied @number@ initially healthy men and women aged @number@ to @number@ years.
Participants who attributed any experiences of discrimination to their age were treated as cases of perceived age discrimination.
Participants who declined greater than @percent@ of their initial measurement were categorized as having reduced AEE.
Participants who fail to return postal questionnaires can introduce non-response bias.
Participants who had the largest increase in BFP had the highest BMI and waist circumference ( WC ) ( P < 0.001 ) .
Participants who identified as White , Black , Hispanic , or Asian / Pacific Islander read a vignette about an older man needing medical care.
PARTICIPANTS who met 1-2 or ≥ @number@ of the @number@ criteria were classified as prefrail or frail , respectively.
Participants who performed one or more healthy behaviors were @percent@ to @percent@ less likely to be disabled than those who performed none.
Participants who refused or were unable to attend a centre were offered a home assessment.
Participants who reported a history of cancer or who had missing data were excluded , yielding @number@ subjects for analysis.
Participants who reported @number@ min or more of vigorous physical activity per week were considered physically active.
Participants who reported spending @number@ or more hours / day in other less physically demanding activities also had significantly reduced risks of death of 15-30%.
Participants who scored < 26 were defined as \ "probable MCI \ " while those who scored ≥26 were labeled cognitively healthy.
Participants who stayed caries-free for a longer period during childhood and adolescence experienced less extensive caries , as measured by the number of carious teeth.
Participants who were biomarker positive were older than those who were biomarker negative.
Participants who were consistently PiB + demonstrated worsening of episodic memory , whereas participants who were consistently PiB- evidenced stable or improved performance.
Participants who were malnourished or at high risk of malnutrition also had a lower rate of quality of life and greater loss of personal autonomy.
Participants who were married , consumed alcoholic beverages , smoked cigarettes and aging males who had children were at a greater risk of developing SD.
Participants who were not frail at baseline were followed for incident prefrailty and frailty.
Participants who were prefrail at baseline were followed for incident frailty.
Participants will also be followed up by linking to health registries until year @number@
Participants will be randomized into two intervention groups or the control / waiting group.
Participants will be randomized into two standardized treatment conditions , MAPs and sleep hygiene education.
Participants will be randomly assigned to either the intervention group ( IG ) or the control group ( CG ) .
Participants will be randomly assigned to the control ( usual care ) or program study arm.
Participants will undergo testing at baseline , @number@ days and @number@ days.
Participants with a CES-D score ≥16 at baseline and those taking antidepressants were excluded and considered to have a current diagnosis of depression.
Participants with a history of stroke , alcoholism , Parkinson's disease , subdural hematoma , traumatic brain injury , or normal pressure hydrocephalus were excluded.
Participants with a history of syncope and / or unexplained falls in the past @number@ months were compared with those with no reported events.
Participants with a known brain-related high risk for mortality ( cognitive impairment or stroke ) were excluded from these analyses.
Participants with aMCI , nonamnestic MCI , AD , and healthy older adults were administered the California Verbal Learning Test-II ( CVLT-II ) .
Participants with a relative change in ASM below the sex-specific 15th value were classified as the low relative ASM group.
Participants with a sensory impairment took on average from @number@ to @number@ seconds longer than participants without the corresponding sensory impairment to complete these tests.
Participants with better results in the CRS test were younger and presented higher levels of physical activity and functional fitness.
Participants with BMI ≥ @number@ kg / m² had @number@ ( @number@ @number@ ) %5 mC higher LINE-1 than those with normal BMI.
Participants with cancer were excluded.
Participants with CMV antibody level≥6 AU / mL were considered to harbor CMV infection.
Participants with complete data on the physiologic index and at least two gait speed measures were included.
Participants with c-sarcopenia had poorer performance in all physical performance tests , whereas h-sarcopenia and w-sarcopenia were associated with poor performance in four tests.
Participants with diabetes / prediabetes at baseline were excluded.
Participants with diseases performed worse than the healthy aging group on all driving measures and differences between those with AD and PD were minimal.
Participants with DS presented lower chronotropic response than controls to peak and submaximal exercise ( p < 0.05 ) .
Participants with DS were assessed for the presence of dementia using the CAMDEX informant interview.
Participants with elevated biomarker levels were typically older and had a lower GFR.
Participants with experience as a family caregiver showed significantly greater preference for individualized care and communication.
Participants with family role models had less negative views on aging.
Participants with GDS > 10 were excluded.
Participants with high educational level tend to be younger and more male significantly.
Participants with higher BMI had greater hypothalamic response during pleasantness evaluation of sucrose in the sated condition.
Participants with higher BMI had lower odds of HV compared to those with normal BMI ( aOR @number@.54-0.72 ) .
Participants with higher cognitive function had significantly higher pleasure ( F ( @number@ ) = @number@ P < @number@ ) .
Participants with higher current household incomes were found to be less affected.
Participants with high-grade PVHs and DWMHs showed lower FA thalamic values compared to those with low-grade PVHs and DWMHs , respectively.
Participants with high protein intake and engaged in regular physical activity showed the higher scores in all the assessed domains.
Participants with hypertension were more likely to have OH ( OR : @number@ @number@.56-5.88 , p = 0.001 ) than those without hypertension.
Participants with imaging consistent with SS were identified from @number@ through @number@
Participants with impaired cognition were more likely to be taking an antimuscarinic than those with normal cognition.
Participants with incident glucose disorders had greater decline in global cognition and visuospatial function compared to normal , similar to that observed in baseline diabetes.
Participants with limitations in lower extremity performance were more susceptible to these environmental barriers.
Participants with low cognitive function had high fall-related self-efficacy.
Participants with MCI and AD at VT3 evidenced higher TC levels at VT1 than those who were healthy.
Participants with MCI showed significantly higher EBR than the healthy controls.
Participants with mild dementia performed significantly better on all six SVTs than those with moderate / severe dementia.
Participants with moderate-to-severe retinopathy had the worst g and the worst performances on the individual tests.
Participants with more MB demonstrated poorer performance irrespective of their level of AB.
Participants with more severe adverse reactions were more likely to be treated with a combination of drugs and surgery.
Participants with MPS walked slower and with disturbed spatial and variability components of gait compared to those without MPS.
Participants with NAFLD at baseline had a higher incidence of both diabetes and prediabetes.
Participants with no lens opacities had higher MPOD values than those with moderate lens opacities ( p < @number@ ) .
Participants with normal or controlled BP were engaged in more household and walking activities than those with uncontrolled BP.
Participants without AMD lesions at any visit were controls.
Participants with poorer mobility at baseline benefited the most ( P < @number@ ) .
Participants with poor functional vision performed worse on all balance and mobility tests.
Participants with poor ratings of health experienced higher rates of anxiety and depression than their healthier counterparts.
Participants with poor social engagement at baseline were at significantly greater risk of incident dementia.
Participants with previously diagnosed heart disease , diabetes , hypertension or other chronic illnesses were excluded from this study.
Participants with prior falls scored lower on cognitive testing and had more comorbidities associated with falls.
Participants with relatively \ "pure \ " HS-Aging pathology were often diagnosed clinically as having probable ( @percent@ ) or possible ( @percent@ ) AD.
Participants with severe pain were identified using a validated pain severity coding system imbedded in the National Health Interview Survey Adult Functioning and Disability Supplement.
Participants with T2DM + DEP demonstrated the highest IL-6 levels compared to all other groups.
Participants with the T / T genotype scored significantly lower on Neuroticism and higher on Conscientiousness and Extraversion scales.
Participants with two versus no myopic parents had approximately @number@ D more myopia at stabilization.
Participants with uncorrected binocular NVA ≤20 / 40 were tested with plus sphere lenses to obtain best-corrected binocular NVA.
Participants with vs. without self-reported prior falls were similar in age , gender , race , and substance use.
PARTICIPANTS : Women aged @number@ to @number@ ( N = @number@ ) with dietary data and one or more physical function measures.
PARTICIPANTS : Women initially aged @number@ to @number@ recruited from Pittsburgh , Pennsylvania , and Memphis , Tennessee ( N = @number@ ) .
PARTICIPANTS : Women ( mean age @number@ ± @number@ ) who had completed questionnaires on HRT use ( N = @number@ ) .
PARTICIPANTS : Women ( n = @number@ ) and men ( n = @number@ ) aged @number@ to @number@
Participants wore a GPS logger for @number@ consecutive days.
Participants wore an accelerometer ( ActiGraph GT3X ) on the right hip for seven consecutive days.
Participants wore an accelerometer-based physical activity monitor at their waist , and oxygen consumption was measured.
Participants wore an accelerometer for @number@ consecutive days.
Participants wore the Actigraph GT3X on the hip for @number@ d twice during the study and the average of the two measurements was used.
Participants wore the insole for @number@ weeks for a minimum of @number@ hours / day.
Participants wore wireless sensors on forearm and upper-arm and performed rapid elbow flexion for @number@ seconds ( the UEF test ) .
PARTICIPANTS : Young ( n = @number@ ) and elderly ( n = @number@ ) healthy , cognitively normal volunteers.
Participating hospices had been in operation for at least @number@ years and were located in any of the @number@ states or District of Columbia.
Participating in @number@ h of LTPA per week had a significant effect on FM% but not on the absolute amount of fat mass.
Participating nursing staff members reported several factors pertaining to the care provider , the older patient , and the institution that precipitated abuse and neglect.
Participating patients received a multidimensional geriatric evaluation.
Participating patients showed a relatively homogeneous socio-economic status.
Participation in a comprehensive exercise program can be safe and effective in regaining pre-stroke levels of cardiorespiratory fitness , functional mobility and goal attainment.
Participation in cognitive activities ( e.g. reading ) and non-exercise physical activity ( e.g. housework ) was assessed by a self-reported scale.
Participation in cognitive activities was a significant predictor of maintenance in a higher cognitive status group.
Participation in endurance exercise program is essential for perimenopausal and postmenopausal Nigerian women for improved central and abdominal adiposity as well as flexibility.
Participation in intergenerational programs can have a positive impact on quality of life and well-being across age groups.
Participation in professional sport may moderate this ethnic disparity.
Participation in regular exercise appears to preserve functional status and may minimize the rate of functional decline.
Participation in six social activities was assessed.
Participation in the program was associated with a reduction in shelter use and jail stays during the two years after program entry.
Participation in valued activities is important for sustaining interest in life and has been associated with enhanced health and well-being.
Participation in work and volunteering roles was viewed as integral to managing neurocognitive challenges and health overall.
Participation of the numbers of men and women rowers were also quantified across years.
Participation problems included loss of income and fewer social activities.
Participation , program duration , and employment placement of minorities are examined.
Participation restriction and a range of other variables were measured using self-report and performance measures.
Participation restrictions were defined as reductions / absence in social activities valued by respondents because of their health or functioning.
Participation was associated with improvements in self-efficacy for managing depression and diastolic blood pressure.
Participation was higher in those with higher levels of prior contact and lower in those with the poorest health status.
Participation was measured with the Craig Handicap Assessment and Reporting Technique ( CHART ) and the Nottingham Leisure Questionnaire ( NLQ ) .
Participation was voluntary , and all participants were asked to complete @number@ sessions over the course of @number@ months.
Particular attention has been paid to age-related disorders because of the overlap of endocrine and neuronal dysfunction with aging.
Particular attention is given to sadness leading to mood congruent memory and to anxiety leading to selective attention bias to threat.
Particular attention is paid to relationships between reflex and escape responding and information on the pain sensitivity of normal human subjects or patients with pain.
Particular attention should be paid to adequate solutions for persons in need of care.
Particular attention will be given to the molecular mechanisms proposed to explain the effects of natural compounds and / or food ingredients against oxidative stress.
Particular efforts should be made to overcome the persisting large survival deficits , which were observed for elderly patients in all clinical subgroups.
Particular emphasis is placed on the differentiation from normal aging processes and from healing stages under steroid therapy.
Particularly , aging and Cx43 deletion increase osteocyte apoptosis , and osteoclast number and bone resorption on endocortical bone surfaces.
Particularly , Aβ plaque-associated microglia take on an \ "activated \ " morphology.
Particularly , coronary heart disease is the commonest cause of death worldwide.
Particularly , DHA may be effective on suppression of vascular proliferation and inflammation.
Particularly fragile and very elderly patients did not receive operative repair.
Particularly important are their own sense of control and available support from children and friends in the new society.
Particularly important are the puborectalis sling of the levator ani muscle complex and intact innervation of the central and peripheral nervous systems.
Particularly in frontal impacts , older females show higher risk to the chest and thorax than their younger or male counterparts.
Particularly in the elderly and immunocompromised patient , the brain may be the first organ to show signs of failure.
Particularly , late-life depression is considered to be more characterized by apathy than is early-life depression.
Particularly , miR-379 was up-regulated in mouse models of hyperglucocorticoidemia and obesity as well as human liver in a GC / GR-dependent manner.
Particularly , proteins such as Gelsolin ( GSN ) , Tenascin-R ( TNR ) and AHNAK could potentially act as novel biomarkers of aging-related neurodegeneration.
Particularly , SASP from stroma senescent fibroblasts creates a cancer-favoring microenvironment , providing targets for anti-cancer interventions.
Particularly , strong associations with cognitive ability were obtained for school education , and consistent sex differences were observed with higher cognitive ability in men.
Particularly , such interventions could preserve the functional status of cancer patients and , consequently , improve their long-term health outcomes.
Particularly , the changes in the lipid saturation , unsaturation as well as in the protein secondary structure were examined.
Particularly , the hydrophobicity of the curcumin molecule hints at the possibility of blood-brain barrier penetration and accumulation in the brain.
Particularly , the Mediterranean diet pattern has been associated with reduced mortality risk in several studies involving both younger and elderly population groups.
Particularly , the patients with type C pathology showed a severe loss.
Particularly , this study aims to bring to the fore the negotiability of health professionals ' perspectivating age ascriptions.
Particularly , transplantation of these cell clusters upon in vitro induction for 3-4 w partially restores hyperglycemia in diabetic nude mice.
Particularly vulnerable are the lower educated older adults.
Particularly , we suggest a distinction between proximal ( e.g. , physical activity ) and distal health behaviors ( e.g. , social participation ) .
Particular nutrients should be translated into dietary patterns which allow the individual patient to address these nutrient deficiencies.
Particular paths of fetal growth are now known to predict a range of disorders in adult life.
Particulate air pollution and fasting blood glucose in nondiabetic individuals : associations and epigenetic mediation in the Normative Aging Study , 2000-2011.
Particulate air pollution , exceptional aging , and rates of centenarians : a nationwide analysis of the United States , 1980-2010.
PART is almost universally detectable at autopsy among elderly individuals , yet this pathological process cannot be specifically identified pre-mortem at the present time.
Partly this is due to progressive deterioration of calcium-phosphate homeostasis.
Partner dance has been shown to be beneficial for the health of older adults.
Partnereds are disproportionately likely to receive Social Security and they enjoy relatively high Social Security benefits and very low poverty levels.
Partnering with community-based organizations may facilitate relationships of trust and may also provide a non-threatening and accessible location for research activities.
Partner resources are more important for the life satisfaction of older people with a low education and health problems.
Partners may consider gift-giving in terms of the act of moving to appease and honor their partner.
Part @number@ of this series described several healthy aging evidence-based programs and discussed collaborative opportunities for senior care pharmacists within these programs.
Part @number@ provides an update on the types of research published on productive aging in AJOT in the past @number@ yr ( 2009-2010 ) .
Part of the inconsistencies may be related to study differences in the stimuli used and the emotional response systems considered.
Part of the increase in prevalence was due to an increased longevity , decreased mortality and increased incidence.
Part of this difficulty may be related to age-related degradations in the neural representation of speech sounds , such as formant transitions.
Part of this effect may be caused by underlying attentional dysfunction , although this could not fully explain the observed memory decline.
Part of this is explained by an adaptation within the β-cell.
PA ( self-reported time spent walking ) was assessed annually from years @number@ to @number@
PA shows promise as a modifiable lifestyle intervention to benefit pathological symptoms of dementia.
Passage of the two channel Foley catheter into his bladder immediately resolved his urinary tract infection , fever , and difficulty in communicating.
Passiflora tarminiana Coppens & V.E. Barney , a species of the Passifloraceae family , is widely distributed in South America and is rich in flavonoids.
Passive immunizations had shown some effects in slowing AD pathology.
Passive interventions such as web-based guidelines should not be used in isolation but as a support to ongoing exposure and engagement by content experts.
Passive leg movement has been used to exclude the influence of central command due to the lack of voluntary activation of muscles.
Passive stiffness was also greater in the older men ( p = @number@ ) .
Passive stiffness was calculated as the slope of the angle-torque curve at 10° angle of dorsiflexion.
Passive stretching is commonly recommended to help reduce passive stiffness in older adults , yet their acute viscoelastic stretch responses are still unclear.
Past a certain level ( and age ) , molecular damage is such that mortality risks start to increase.
Past alcohol-drinkers had less anxiety than nondrinkers ( β = @number@ p = @number@ ) .
Past descriptive epidemiologic studies suggest that the cohort effect is not negligible in cancer mortality.
Past exposure to common infections may contribute to vascular cognitive impairment and warrants further study.
Past mental health service experiences influenced whether youth viewed treatment options as beneficial.
Past receipt of financial help from parents was not associated with coresidence.
Past research demonstrates a positive association between DHA plasma status / dietary intake and cognitive function.
Past research has shown that anticipated support , the belief that someone will provide support if needed , benefits health.
Past research has yielded some evidence of age differences in participants ' reports of verbal transformations.
Past research suggests an aging-related positivity effect in orienting to faces.
Past studies have extensively examined factors associated with coping strategies that caregivers use to ameliorate distress or solve problems.
Past studies have suggested that Stroop interference increases with age ; however the robustness of this effect after controlling for processing speed has been questioned.
Past studies of whether regional atrophy accounts for episodic-memory decline in aging have yielded inconclusive findings.
Past studies on changes along geriatric trajectories in the association between social engagement and depression also remain inadequate.
Past-year mental health service use was categorized into whether services were utilized in the general or specialty sectors.
Patchy fibrosis was predominantly demonstrated in the pediatric patients , whereas perivascular fibrosis was mostly observed in the older adults.
Patent citation network analysis was used to visualize the technology relationship.
Paternal age and birth order were not associated with exceptional longevity.
Paternal age was not found to affect embryo quality at the cleavage stage ( days 2-3 ) .
Paternal aging is associated with increased risk of genetic disease transmission to the offspring.
Path analyses allowed us to identify direct and indirect predictors of suicide ideation among older adults with BD.
Path analyses indicated that fitness-related changes in complex object recognition were modulated by hippocampal perfusion.
Path analysis examined the relation of age , APOE , and the @number@ pathologic indices to the slopes of cognitive decline.
Path analysis was used to assess interrelations among functional disability , activity restriction , perceived stress , social support , and depressive symptoms over time.
Path analysis was used to determine the independent contribution of cognitive dispersion to functional ability , mediated by multitasking.
Path analysis was used to estimate the relationships among these factors.
Path analysis was used to examine the study objectives.
PATH is based on problem-solving therapy and integrates environmental adaptation and caregiver participation.
PATH is consistent with Lawton's ecologic model of adaptive functioning in aging.
Path length and width were constant across tasks.
Pathogenesis of age-related macular degeneration ( AMD ) , the leading cause of blindness in the world , remains poorly understood.
Pathogenic bacteria and treatment in these cases were reviewed.
Pathogenic BRCA1 and BRCA2 germline mutations were present in @number@ of the @number@ patients ( @percent@ ) .
Pathogenic CD4 ( + ) T cells that develop with aging are capable of transferring DED from older mice to naive immunodeficient recipients.
Pathogenic COL6A1-3 mutations were mostly missense or in frame exon-skipping resulting in substitutions or deletions.
Pathogenic massive hexanucleotide repeat expansion mutation in C9ORF72 was detected in @percent@ of patients and was the most common cause of the disease.
Pathogenic mutations in other NBIA genes were not found.
Pathogen identification to species level by molecular methods and susceptibility testing are strongly recommended to establish epidemiological knowledge.
Pathological apoptosis , a process similar to apoptosis , is associated with aging and infection.
Pathological bone porosity was analysed.
Pathological-changed vertebra-space fused.
Pathological changes in macular volume , optic nerve fiber layer thickness and the ganglion cell complex were observed.
Pathological conditions can induce changes in elastic properties , having profound effects on their prognosis.
Pathological examinations revealed neurodegeneration and intranuclear polyQ protein inclusions accompanied by gliosis , which recapitulate the neuropathological features of polyQ disease patients.
Pathological hyperphosphorylation and aggregation of the tau protein is associated with dementia and can be the central cause of neurodegeneration.
Pathological inclusions in neurons and glial cells containing fibrillary aggregates of abnormally hyperphosphorylated tau protein are characteristic features of tauopathies.
Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associated with inflammation , chronic kidney disease and some cancers.
Pathological processes usually superimpose on physiological aging even in the sensory system including visual , hearing , olfactory , taste and somatosensory functions.
Pathological samples were ascertained following autopsy in each individual brain bank , whereas clinical samples were collected after participant examination.
Pathological studies report consistent loss of PAX2 in benign lesions as well as serous tumors.
Pathological tau aggregates occur in Alzheimer's disease ( AD ) and other neurodegenerative tauopathies.
Pathological TDP-43 was present only rarely in the CO group.
Pathologic conditions of the oral cavity , pharynx , esophagus , and proximal stomach can manifest with dysphagia.
Pathologic degeneration was more severe in the anterior portion of the frontal lobe with extensive white matter degeneration.
Pathologic examination revealed relatively large cells diffused within a background of many small lymphocytes and histiocytes.
Pathologic investigation revealed extensive spongiform change in the cerebral cortex , particularly in the deeper layers.
Pathologies included sclerodermoid change , prominent superficial veins , dyspigmentation , and alopecia.
Pathologies were associated with faster declines in older individuals.
Pathologists were classified as GU or non-GU on the basis of training and experience.
Pathologists were recruited from diverse practices in @number@ states in the United States.
Pathology of the musculoskeletal system is widespread in the population and is one of the most common diseases of patients in older age groups.
Pathology study confirmed the diagnosis of DLBCL.
Pathophysiologically , genetic alterations compromising the endosomal / lysosomal system are linked with age-related neurodegenerative disorders.
Pathophysiologically , iERM formation is a fibrotic process in which myofibroblast formation and the deposition of newly formed collagens play key roles.
Pathophysiological mechanisms underlying Alzheimer's disease ( AD ) remain insufficiently documented for the identification of accurate diagnostic markers and purposeful target discovery and development.
PATHOPHYSIOLOGY : Most fracture patients have fallen , but actually do not have osteoporosis.
Pathway analyses demonstrated that methylation levels associated with age and BMI are overrepresented among genes involved in cancer , type @number@ diabetes and cardiovascular disease.
Pathway analyses implicated adipogenesis , angiogenesis , transcriptional regulation and insulin resistance as processes affecting fat distribution , providing insight into potential pathophysiological mechanisms.
Pathway analysis revealed alterations in genes involved in MAPK signaling , genes involved in extracellular matrix ( ECM ) regulation , and cytokine-receptor interactions.
Pathway analysis shows this to be dependent on improved dietary quality by eating-with-others.
Pathway analysis was performed using the gamma method.
Pathways analysis showed enrichment for telomere maintenance , ribosomal RNA , and apoptosis.
Patient acceptability rate of Uma Jeunesse® was also much higher.
Patient age and further age-related nonophthalmological systemic diseases also influence adherence and persistence to the prescribed therapy.
Patient age correlated negatively with choroidal thickness.
Patient age is the biggest risk factor for multiple chronic conditions that often occur simultaneously within a single individual.
Patient age was considered in @number@ ways : as a continuous variable , dichotomized at age @number@ years , and categorized by decade.
Patient and doctor satisfaction scores were generally correlated.
Patient and hospital demographics were also analyzed.
Patient and informant characteristics were compared between those with and without NSD by dementia diagnosis ( DLB and probable AD ) .
PATIENT AND METHODS : An integrated care pathway model was implemented.
PATIENT AND METHODS : This was a split-face , evaluator-blind , randomized controlled study.
Patient and photographic assessments showed overall improvement in skin appearance.
Patient and physician scoring of photodamage occurred at baseline and final visits.
Patient and surgical characteristics were documented.
Patient and treatment characteristics and cancer-specific survival were compared between the groups.
Patient assessment also revealed improvement over baseline for the combination therapy at @number@ month.
Patient assessments and clinical gradings by the Wilcoxon's test of outcomes correlated with more aggressive settings.
Patient body habitus measurements and history of associated comorbidities were also described.
Patient-centered care requires health professionals to look past news headlines and unchecked social media so they can deliver high-quality care to all patients.
Patient-centered outcomes are collected from telephone surveys administered at @number@ days.
Patient characteristics and outcomes were ascertained from Medicare Claims , Minimum Data Set assessments , and facility electronic medical record data.
Patient characteristics and treatment were identified from administrative claims.
Patient characteristics , as well as operative and perioperative details , were compared between the two groups.
Patient characteristics , duration of AF , and choice of antithrombotic therapy were recorded.
Patient characteristics including the ASA-status , the ACE-27-score , flap survival and postoperative medical and surgical complications were evaluated.
Patient characteristics , treatment , quality-of-life , healthcare resource use , and costs were systematically assessed.
Patient comorbidities , repair procedures , and postoperative recovery , recurrence , and complications were noted.
Patient concerns : Here we present a 20-year-old man who exhibited lower extremity weakness and foot drop as the initial manifestation.
Patient data collected from @date@ until @date@ were individually reviewed and validated by a registered nurse.
Patient data were collected from chart reviews and an electronically stored database.
Patient decision making is an area of increasing inquiry.
Patient demographic and clinical characteristics ( pain , depression , cognition , comorbidity ) were collected upon admission.
Patient demographic and hospital characteristics were compared for the two cohorts using t-tests.
Patient demographic and radiographic data were obtained.
Patient demographics , pleural fluid , radiologic and treatment characteristics , and outcomes were collected.
Patient-derived primary fibroblasts had strongly decreased CDK5RAP2 amounts , showed centrosomal and nuclear abnormalities and exhibited changes in cell size and migration.
Patient examination is important to distinguish these from other more infrequent types of ptosis , such as those neurogenic , myogenic and posttraumatic.
Patient feedback reports summarize discrepancies and self-reported medication problems.
Patient follow-up occurred at @number@ months to assess outcomes.
Patient improvement in self-management was measured by pre- and postintervention self-efficacy scores and clinical measures.
Patient information was collected at admission and extracted from the chart during hospitalization.
Patient leukocyte telomere length was not associated with survival.
Patient lymphoblasts carrying a UBQLN2 mutation showed absence of ubiquilin-2 accumulation , disrupted binding with HSP70 , and impaired autophagic pathway.
Patient notes containing specific keywords denoting criminal behavior were reviewed.
Patient organizations are encouraged to share the survey with local clinicians to ensure accuracy of responses.
Patient outcomes and process measures before and after intervention will be compared between intervention and control wards.
Patient portals are intended to bridge patients and providers by ensuring patients have continuous access to their health information and services.
Patient preferences can affect compliance and persistence behaviours.
Patient privacy regulations and the need for extensive outreach to establish relationships between community partners and clinical sites hampered initial recruitment.
Patient-proxy discrepancies increase also with disease severity , degree of memory problems and cognitive control deficits.
Patient-proxy discrepancies were associated with lower verbal learning , poor cognitive control and more severe PD symptomatology.
Patient questionnaires were used to assess their levels of satisfaction.
Patient ratings for overall improvement for each side were also recorded.
Patient-reported outcome measures were analyzed by subgroups ( age , gender , and baseline CFL severity ) .
Patient-reported outcomes were measured using the Duke Health Profile and the BREAST-Q.
Patient-reported symptomatic improvement at the first post-operative visit was @number@ percent ( 50 / 91 ) .
Patient risk factors did not differ between groups.
Patients 15-69 years old diagnosed with CML were included in the analysis.
Patients admitted through ER had a shorter LOS compared with those elective ( @number@.4±6.7 vs. @number@.0±6.7days ; p < 0.0001 ) .
Patients admitted to departments of pediatrics , obstetrics and gynecology were not included.
Patients admitted to Geriatric Clinic of Padua were studied.
PATIENTS : Afebrile , Triage Category @number@ ( low priority ) patients aged 0-15 years attending the ED.
Patient safety is an overarching theme inherent in hospital care.
Patient safety is paramount , yet older doctors are an important part of the medical workforce and their value should be recognised.
Patients affected by mandibuloacral dysplasia type A suffer from partial lipodystrophy , skin abnormalities and accelerated aging.
Patients after aSCT without ocular GvHD had no significant difference in uMGA in comparison with controls.
Patients age 15-69 diagnosed with ALL were included.
PATIENTS : Aged ≥25 years with mild to moderate ( Kellgren-Lawrence grade 1-3 ) knee OA.
Patients ( aged 60-80 years ) were divided into three groups.
Patients aged ≥65 years had ADs @percent@ to @percent@ of the time.
Patients aged ≥65 years represented @percent@ and ≥80 years @percent@.
Patients aged from @number@ to @number@ years , @number@ males and @number@ females , yielding a ratio of @number@.7 : 1.
Patients aged @number@ and older caused approximately @percent@ of costs.
Patients aged @number@ or older ( n = @number@ ) were prospectively recruited.
Patients aged @number@ years and over with non-valvular AF were identified in a database of @number@ hospital stays.
Patients aged @number@ years or older were identified over @number@ months , representing @number@ months prior and also after the implementation of the new program.
Patients aged ≥ @number@ years were twice as likely to visit the ED as younger patients.
Patients aged over @number@ years showed no difference using the two techniques.
Patient's age is an important factor in orthodontic treatment.
Patient's age plays an important role in orthodontic treatment , because of the bone response to mechanical loading.
Patients ages sixty-five and older are more likely than younger patients to fall and suffer serious injury or death as a result.
Patients aging between @number@ and @number@ consisted of @percent@ of the sample.
Patients agreed to undergo a contemporary hydrocephalus assessment.
PATIENTS : All consecutive critically ill patients admitted with sepsis , involving @number@ admissions ( @number@ patients ) .
Patients All neonates in the neonatal intensive care unit receiving invasive intubation for more than @number@ week from @date@ , through @date@ .
Patients also completed a self-assessment questionnaire concerning satisfaction with the treatment.
PATIENT SAMPLE : The subjects were @number@ men from @number@ to @number@ years of age at baseline.
PATIENT SAMPLE : This study included @number@ consecutive patients who underwent spinal fusion using a total of @number@ cement-augmented screws.
Patients and caregivers were assessed every @number@ months for @number@ months.
Patients and clinicians are increasingly wary about treatment since no medication appears to be safe.
Patients and controls differed significantly in Rey Auditory-Verbal Learning test ( immediate and delayed recall ) , Stroop test and Digit span backward scores.
Patients and controls performed equally well and there were no effects of oxytocin administration on the control task.
Patients and controls were asked to perform a sequential finger-tapping task using their right , left , and both hands , respectively.
Patients and controls were compared as a whole sample and within specific telomere range ( short and long telomeres ) .
PATIENTS AND METHOD : Retrospective analysis of a single series of patients treated with L-polylactic acid ( Sculptra™ ) between @date@ and @date@ .
PATIENTS AND METHODS : A cohort of patients with RCC was identified restrospectively , with an age range of 35-84 years.
PATIENTS AND METHODS : A prospective 3-year study was conducted in our institution from @date@ to @date@ .
PATIENTS AND METHODS : A randomized , prospective intervention study was undertaken among @number@ elderly patients.
PATIENTS AND METHODS : A retrospective analysis of @number@ postlingually deafened elderly ( ≥60 years of age ) with unilateral cochlear implants was conducted.
PATIENTS AND METHODS : A retrospective review of all patients undergoing robot-assisted surgery in our General Surgery Unit from @date@ to @date@ was conducted.
PATIENTS AND METHODS : A retrospective review of patient demographics , diagnoses , surgical treatments , and early postoperative outcomes was performed.
PATIENTS AND METHODS : A sole-mounted sensor system was developed for an unobtrusive measurement of acceleration during gait.
PATIENTS AND METHODS : A total of @number@ critically ill patients and @number@ normal controls were recruited for this study.
PATIENTS AND METHODS : A total of @number@ meningioma patients ( @number@ men and @number@ women ) aged between @number@ and @number@ years were included.
PATIENTS AND METHODS : A total of @number@ patients diagnosed with OVCF , from @date@ to @date@ , were retrospectively reviewed.
PATIENTS AND METHODS : A total of @number@ patients with pT1-T2 , pN0-N1 invasive breast carcinoma treated from @number@ to @number@ were retrospectively evaluated.
PATIENTS AND METHODS : Cancer patients diagnosed in 1997-2006 were included.
PATIENTS AND METHODS : Clinical data on eight adult patients with cayenne aspiration were retrospectively analyzed.
PATIENTS AND METHODS : Digital panoramic radiographs of @number@ geriatric edentulous patients were analyzed.
PATIENTS AND METHODS : Eighty-four eyes from @number@ healthy adult volunteers were included.
PATIENTS AND METHODS : Fifty consecutive PAD and non-PAD elderly patients performed a progressive treadmill test.
PATIENTS AND METHODS : Fifty-one subjects ( aged 20-80 years ) with no known neuromotor disorders of the upper limbs participated in the study.
PATIENTS AND METHODS : Fifty-two elderly cancer patients and @number@ age-matched controls without personal history of cancer were enrolled.
PATIENTS AND METHODS : Forty patients have been enrolled in this prospective study.
PATIENTS AND METHODS : Fragility hip fracture patients in the two most southern counties in Norway who experienced fractures in @number@ and @number@ were studied.
PATIENTS AND METHODS : From @number@ to @number@ @number@ patients underwent resection of esophageal or gastric cancer at the University of Heidelberg.
PATIENTS AND METHODS : \ "Hidden elderly \ " is a term used to describe older adults who are socially isolated and refuse social participation.
PATIENTS AND METHODS : In a retrospective study @number@ surgeries were evaluated.
PATIENTS AND METHODS : In this study , there were @number@ participants ( @number@ males and @number@ females ) .
PATIENTS AND METHODS : Knee MRI images of @number@ symptomatic patients with various pathologic knee conditions were analyzed retrospectively.
PATIENTS AND METHODS : Medication lists were retrospectively abstracted from the electronic medical records of ambulatory patients aged 60-89 years with heart failure.
PATIENTS AND METHODS : Nineteen elders with dementia were followed through a control period and an acupuncture treatment period , each lasting @number@ weeks.
PATIENTS AND METHODS : Ninety-three 3- to 10-year-old children grouped from @number@ to @number@ @number@ to @number@ and @number@ to @number@ years served as participants.
PATIENTS AND METHODS : @number@ patients , aged ≥65 years , admitted during @number@ and @number@ in our geriatric unit , were studied.
PATIENTS AND METHODS : @number@ patients were randomly divided into two groups , on the basis of conventional treatment.
PATIENTS AND METHODS : One eye from @number@ participants with open angles was imaged.
PATIENTS AND METHODS : One hundred pediatric patients were retrospectively evaluated using a high-resolution 3-T imaging protocol.
PATIENTS AND METHODS : Participants included @number@ individuals aged @number@ to @number@ years enrolled in the population-based Mayo Clinic Study of Aging.
PATIENTS AND METHODS : Seven focal groups with @number@ patients from associations and health departments were conducted.
PATIENTS AND METHODS : Seventy elderly residents in a long term care facility were included in this study.
PATIENTS AND METHODS : Since @date@ data about every fracture of the hip sustained in an adult have been collected centrally in Northern Ireland.
PATIENTS AND METHODS : Six hundred forty-three participants aged @number@ years were examined.
PATIENTS AND METHODS : Sixteen patients with malignant brain tumours were included in the study.
PATIENTS AND METHODS : Subjects aged @number@ years and older underwent Cirrus OCT scanning.
PATIENTS AND METHODS : Surveys are distributed to EHC member organizations in English and Russian.
PATIENTS AND METHODS : Systematic and directed literature review.
PATIENTS AND METHODS : Systematic review of the literature published between inception of the databases and @date@ .
PATIENTS AND METHODS : The geriatric outpatients evaluated in this study had previously been included in a prospective descriptive study conducted in @number@
PATIENTS AND METHODS : The present study included @number@ elderly patients with non-obstructive dysphagia.
PATIENTS AND METHODS : The research subjects were patients attending the Clinic of Geriatrics : @number@ women and @number@ men ; @number@ persons in total.
PATIENTS AND METHODS : The research was carried out in @number@ patients with breast cancer undergoing radiotherapy in the Oncological Center in Bydgoszcz , Poland.
PATIENTS AND METHODS : There were @number@ patients ( ≥60 years ) with CHF chosen as study subjects.
PATIENTS AND METHODS : The Vanderbilt Inpatient Cohort Study includes adults hospitalized with acute coronary syndromes and / or acute decompensated heart failure.
PATIENTS AND METHODS : This prospective randomized controlled study included @number@ patients with NSTEMI older than @number@ years.
PATIENTS AND METHODS : This study analyzed chemotherapy usage in patients with EBC treated at the Heidelberg University Breast Unit between @date@ and @date@ .
PATIENTS AND METHODS : This was a multicenter , retrospective , cross-sectional study and medical records of @number@ eyes were reviewed.
PATIENTS AND METHODS : This was a prospective , follow-up study of elderly patients diagnosed with MDD and receiving treatment in Thailand.
PATIENTS AND METHODS : This was a retrospective cohort study of @number@ elderly male COPD patients ( mean age @number@ ± @number@ years ) .
PATIENTS AND METHODS : Twenty-seven patients with an age of at least @number@ years were enrolled and randomized into control and intervention group.
PATIENTS AND METHODS : Twenty women with mild to very loose aged upper arm skin underwent two treatments with an infrared device @number@ month apart.
PATIENTS AND METHODS : Two hundred and five volunteers aged ≥45 years were randomly divided into two groups.
PATIENTS AND METHODS ; Using the @number@ Medicare Current Beneficiary Survey , we analyzed a national sample of @number@ community-based elders.
PATIENTS AND METHODS : We analyzed the SPECT images of @number@ patients with CH and those of @number@ control individuals.
PATIENTS AND METHODS : We describe a male and a female patient with MDPL respectively affected with mild and severe phenotypes.
PATIENTS AND METHOD : We hospitalized in urgency @number@ patients , aged over @number@ for sigmoid diverticulitis.
Patients and physicians also had higher satisfaction with overall care.
Patients and physicians noted significant reduction in photoactinic damage and actinic keratoses.
PATIENTS AND SETTING : A total of @number@ inpatients aged ≥65 years in geriatric wards of a general hospital participated in the study.
Patients and staff reported limited availability of strength and balance follow-up classes.
Patients and staff wanted greater availability of long-term exercise services for falls prevention.
Patients and surgeons may use this simple calculator to better manage the preoperative risks.
PATIENTS : Any patient with PDB living in New England was eligible to enroll ; @number@ elected to participate , mean age @number@ years.
Patients appreciated the convenience of the treatment.
PATIENTS : Approximately @number@ patients younger than @number@ years who received a first CI from @number@ to @number@
Patients are first diagnosed with PPA and are then divided into clinical variants based on specific speech and language features characteristic of each subtype.
Patients are followed-up for an average of @number@ years.
Patients are increasingly seeking procedures with little to no downtime , lower risk profiles , and a more natural appearance.
Patients are monitored for specific adverse events of interest including incident atrial fibrillation , heart failure and bone fracture.
Patients are randomised to either maximum conservative treatment alone or in addition to early hemicraniectomy within @number@ h after symptom onset.
Patients at an advanced age should be counseled and evaluated before undergoing infertility treatments.
Patient Satisfaction.
Patient satisfaction , complications and symptoms after surgery and frequency of repeated surgery were evaluated by sending a questionnaire with subsequent telephone survey.
Patient satisfaction is an important factor for successful therapy.
Patient satisfaction is high.
Patient satisfaction rates were high.
Patient satisfaction score and side effects during each treatment were also recorded.
Patient satisfaction surveys revealed that a majority of patients were satisfied with their results.
Patient satisfaction was also evaluated on a 0-4 point scale ( 0 = No satisfaction ; 4 = Excellent perceived improvement , 76-100% ) .
Patient satisfaction was assessed in a standardized follow-up survey.
Patient satisfaction was collected from the Healthcare Providers and Systems Survey ( HCAHPS ) .
Patient satisfaction with skin appearance was not correlated to the profilometrically measured reduction of wrinkle size of any facial area.
Patient satisfaction with the AxiaLIF procedure was @percent@.
PATIENTS : A total of @number@ asymptomatic individuals @number@ to @number@ years of age.
PATIENTS : A total of @number@ cases from @number@ patients were reviewed of which @number@ cases from @number@ patients who underwent diagnostic procedures were included.
PATIENT ( S ) : A total of @number@ infertile women.
Patients : A total of @number@ white women aged ≥40 years.
PATIENT ( S ) : A total of @number@ women.
PATIENT ( S ) : A total of @number@ women of reproductive age ranging from @number@ to @number@ years old.
Patients at risk for osteoporosis include those treated with aromatase inhibitors and with androgen deprivation for more than @number@ year.
Patients attended the clinic once annually for three years to complete the scales.
Patients attending a geriatric outpatients ' clinic were recruited ( Pfeiffer score < 5 ) .
Patients below @number@ years of age were categorized as ' younger ' and those at least @number@ as ' elderly'.
PATIENT ( S ) : Carriers of massive and complex chromosomal rearrangements.
Patients ' characteristics were not related with care-givers ' stress at baseline.
Patients ' clinical characteristics did not differ between wards in the observational or intervention years.
Patients commonly have lymphopenia and Ig-production abnormalities.
PATIENTS : Community-dwelling older adults.
PATIENTS : Community-dwelling participants.
Patients completed an assessment battery that included the NEO-Five Factor Inventory.
Patients completed a questionnaire of autonomic symptoms.
Patients completed a specifically designed golf survey.
Patients completed , at baseline , several validated questionnaires regarding their psychosocial characteristics and their perceived level of FP involvement.
Patients completed Dry Eye Questionnaire @number@ underwent tear film evaluation , and had serum androgen levels measured.
Patients completed the Response Style Questionnaire , which provided a measure of adaptive rumination associated with better response to psychotherapy.
PATIENTS : Consecutive patients admitted to a GEM rehabilitation ward were eligible for inclusion.
Patient's decisions did not take into account alternative treatment options either because these had not been presented by doctors or because medical management had failed.
Patients ' demographic and medical data were recorded and anthropometric measurements were performed.
Patients denied any pain during the first two and half hour exposure.
Patients described multiple moves , often did not know what to expect , appreciated help from a family member and desired effective communications with physicians.
Patients deteriorated significantly during the five years follow-up.
Patients determined as high risk were additionally placed under permanent personal supervision.
Patients develop severe atherosclerosis.
Patients diagnosed at ≥ @number@ years old were included.
Patients diagnosed with clinically localized disease identified as intermediate or high-risk are often treated by radical prostatectomy.
Patients diagnosed with dementia at discharge by DSM-IV-TR criteria and MMSE scores formed the dementia group.
Patients discharged from usual care hospitals represent the control group and receive the standard of care in place at that hospital.
Patients displaying Wild-type KIT significantly presented higher perceived stress levels.
PATIENT ( S ) : Eighteen hundred sixty-six infertile patients.
PATIENTS : Eighteen patients who required intensive insulin therapy.
Patients ' electronic medical records were merged with Medicare claims , Medicaid claims , the Minimum Dataset , and the Outcome and Assessment Information Set.
Patient self-care must be tailored to the clinical characteristics , patterns of service use and barriers to self-care of the client.
Patients excluded from analysis had undergone prior stress urinary incontinence surgery or had prolapse stage greater than II.
PATIENTS : Female patients with no history of ocular pathology who underwent elective robotic or laparoscopic hysterectomy.
PATIENTS : Five hundred eighteen adult ( ≥ @number@ yr ) patients.
PATIENTS : Five subjects undergoing elective cardiothoracic surgery.
Patients fortunate enough to receive a transplant are required to receive immunosuppressive therapies and can face transplant rejection.
PATIENT ( S ) : Forty-two healthy women ( aged 26-52 years ) undergoing oophorectomy for benign gynecologic indications.
PATIENT ( S ) : Four hundred fifteen premenopausal women were recruited for the study.
Patients from early ART and later ART groups had received ART for at least @number@ year.
Patients from the aging group appeared to have higher atazanavir exposure compared to the younger group.
Patients from the aging group had a reduced creatinine clearance ( @number@ versus @number@ ml / min ) .
Patients gave information on SRH , cognition ( SMC and MMSE ) , quality of life ( EQ-5D ) and socio-demographics.
PATIENTS : General population undergoing cervical CT scanning.
Patients had nonsurgical rejuvenation starting at an average age of @number@ years and rhytidectomy at an average age of @number@ years.
Patients had significantly higher rates of health-related contacts , medication use and greater socioeconomic costs than controls.
Patients had the favorable average levels of lipoproteins of high density ( not lower than @number@ mmol / l ) .
Patients having and not having preoperative IS were matched on their propensity scores using a 1 : 1 greedy matching technique.
Patients having shallow ACDG and narrow ACA showed more rapid deterioration of visual field than those having deep ACDG and wide ACA.
Patients ' higher depressive symptoms were significantly associated with positive and negative affective responses to their spouses ' social control attempts.
Patients homozygous for X allele were followed up from 2010-2015.
Patients hospitalized with influenza were treated with IVZ @number@ mg twice daily for five days.
Patients in active follow-up increased from @number@ patients at four sites in @number@ to @number@ patients at eight sites in @number@
Patients included community-dwelling individuals aged @number@ years or older on @date@ .
Patients included had undergone surgical excision of an SCC.
Patients Index cases of @number@ families with autosomal dominant cerebellar ataxia negative for CAG repeat expansions in coding exons.
Patients in DLB , LAD , VaD , MIX , other , and NOS groups had higher CSF / serum albumin ratio than controls.
Patients in each age group applied > 90% of scheduled doses.
PATIENT ( S ) : Infertile women who visited the Infertility Clinic.
Patients initially diagnosed as unknown or with subjective memory impairment who were later rediagnosed with aMCI / AD scored poorly on their original TYM-MCI.
Patients in remission after ECT had a lower risk of SMW.
Patients in the all high class had the worst QOL scores.
Patients in the CCF group were given CCF exercises and those in the CF group received CF exercises.
Patients in the continuation group continued to receive statins.
Patients in the first tertile of TSH and FT₃ exhibited a significant higher mortality due to CV disease.
Patients in the intervention group also received in-home occupational therapy delivered in @number@ sessions over @number@ years.
Patients in the midface group were injected with Juvéderm Voluma® XC , Juvéderm® Volift® with lidocaine , Restylane- L® , Perlane-L® or Radiesse®.
Patients in the palliative sub-group treated with PDR had higher rates of hospitalization compared to those treated with standard doses.
Patients in the perioral and / or lip group were injected with Juvéderm® Volbella™ , with lidocaine , or Belotero Balance™.
Patients in the PRF group also used less pain medications.
Patients in the quartile of freshest RBCs had lower crude hospital and 90-day mortality rates compared to those in the quartiles of older blood.
Patients in the second ward were observed as a control group ( CG , n = @number@ ) .
Patients in this age group present with a spectrum of diseases different from those of older children or adults.
PATIENTS : In total @number@ narcolepsy patients were included in the study.
Patients in whom there was a treatment gap of at least @number@ months without antiplatelet medication prescription were defined as \ "non-persistent \ ".
Patients kept a headache calendar that was used for data collection.
Patients ' median ( q1 , q3 ) age was @number@ years ( @number@ ) and LOS was @number@ days ( @number@ ) .
PATIENTS / METHODS : A split-face , randomized and evaluator-blinded comparison study.
PATIENTS / METHODS : Sequential reproductive manipulations were performed with cryopreserved semen from a deceased affected ram.
Patients more than @number@ years old should receive prompt evaluation for causes of infertility after no more than @number@ months of attempted conception.
Patients must be at least @number@ years old and living in the region of Burgundy-Franche-Comte ( France ) .
Patients ( n = 288 ) rated their agreement regarding the prescribed treatment after the encounter and reported adherence @number@ month later.
Patient's near-death awareness preceded all other phases , if communicated by the decedent with their family.
Patients need to be monitored closely for side effects.
Patients ( N = @number@ ) received IP and TP testing @number@ weeks apart.
PATIENT ( S ) : Normal appearing ovaries collected from @number@ women ( age 28-51 years ) undergoing oophorectomy for benign gynecologic indications.
Patients : @number@ community-dwelling participants with Alzheimer disease and their informal caregivers.
Patients - @number@ GMC , @number@ ODP.
PATIENTS : @number@ hypertensive patients.
PATIENTS : @number@ male physicians aged @number@ years or older.
PATIENTS : @number@ primary care patients with body mass index of @number@ kg / m2 or greater.
Patients ≥ @number@ years developed hypertriglyceridaemia less frequently ( @percent@ Vs @percent@ , P = 0.031 ) .
PATIENTS : Obese subjects , free of known comorbidities , were enrolled.
Patient sociodemographic and health status factors are associated with increased rates of AD completion , though rates are low for all populations.
Patients of aesthetic dermatology are healthy and therefore place higher demands in contrast to ill patients of medical dermatology.
Patients of @number@ years and above were enrolled in the Nepali fiscal year 2067 ( @date@ - @date@ ) .
Patients often complain of back pain , typically increased with extension and relieved by flexion.
Patients often downplayed the risks of falls and were reluctant to call for help.
Patients often have a postural tremor as well.
Patients often suffer from severe neuropathic pain that may be difficult to treat.
Patients of the present study were compared against a random sample of @number@ patients selected from polyclinics.
Patients of young age get definite rehabilitation but elderly people are often really alone with cleft palate negative symptoms.
Patients older than @number@ years at an outpatient clinic without abnormal gait patterns , lower limb deformities , or foot pain were enrolled.
Patients older than @number@ years were defined as elderly.
PATIENTS : One hundred and one patients with moderate-to-profound hearing loss who ranged in age from @number@ to @number@ years.
PATIENTS : One hundred twenty-six survivors of a critical illness.
Patients on hormone substitution or other medication known to influence testosterone levels were excluded.
Patients on oxycodone DETERx remained in the study longer than those on placebo.
Patients on PA were compared with those who were not.
Patients on TCM were more likely to have higher number of co-morbidities compared to their counterparts.
Patients , on the other hand , generally seek treatment to remove the lesions and achieve an improved appearance of their skin following treatment.
Patients on TRT reported rapid and sustained improvements in QOL , with fewer sexual , psychological , and somatic symptoms.
Patients ' opinions also showed an improvement in their self-image up to four months after treatment , according to the self-grading.
Patients or Other Participants : Of the @number@ ovarian specimens from BMCs , @number@ met the study inclusion criteria.
Patients or Other Participants : Thirty-five ( @number@ obese ) apparently healthy subjects.
Patients outside clinical trials seldom benefit from evidence-based monitoring.
PATIENTS : Participants in the screening colonoscopy program from @number@ to @number@
Patients participated in a six-week multidomain cognitive training program including @number@ sessions each @number@ min twice weekly in mixed groups with both women and men.
PATIENTS : Patients included women who were premenopausal at the time of diagnosis of early breast cancer.
PATIENTS : Patients with PPGLs included @number@ with and @number@ without identified germline mutations or hereditary syndromes.
PATIENTS : Patients with radiographically confirmed PDTB.
Patient-specific organ dose estimation is possible using the size-based methods , and VirtualDose agrees with size-based method for the organs investigated.
Patients ' perceived need and ability to manage pain with support from others is necessary for pain self-management to occur.
Patients ' postoperative apparent age estimate was @number@ years younger than their real age ( p = 0.0002 ) .
Patients post-thyroplasty rated their voices as significantly closer to their best voice than patients postinjection.
Patients ' preferences and cosmetic effect were also assessed.
Patients prescribed uric acid-lowering agents and those with congestive heart failure , valvular heart disease , or ischemic heart disease were excluded from this study.
Patients presenting for management of their clinical opiate substance use disorder ( SUD ) were therefore compared with general medical non-SUD ( N-SUD ) patients.
Patients presenting with middle-aged onset of delusions should be screened for C9ORF72 mutations , especially if family history and parkinsonism are present.
PATIENTS : randomly divided into two groups and each group consisted of @number@ women.
Patients rated pain during the procedure and provided subjective assessment of their outcome at @number@ days.
Patients rated their satisfaction on a scale from @number@ ( very satisfied ) to @number@ ( very dissatisfied ) .
Patients rated their satisfaction using a 5-point scale.
Patients rated their satisfaction using a 5-point scale.
Patients received acute care @number@ times ( median frequency @number@ IQR @number@ @number@ ) for @number@ unique medical issues.
Patients received a total of @number@ glabellar treatments over a mean of @number@ years , with a mean dose of @number@ U per treatment.
Patients received continuous bedside ECG monitoring for at least @number@ hours.
Patients received daily afatinib less than or equal to @number@ mg ( monotherapy ) .
Patients received follow-up for a mean of @number@ months.
Patients received subcutaneous teriparatide @number@ μg daily for up to @number@ months.
Patients receive dual antiplatelet therapy ( DAPT ) for 6-12 months after drug-eluting stents ( DES ) implantation.
PATIENT ( S ) : Recently menopausal participants enrolled in the Kronos Early Estrogen Prevention Study ( KEEPS ) .
Patients recorded AEs in daily dairies.
Patients refusing the MCA were used as control.
Patients reported being very satisfied with the results of the surgery initially ( @percent@ ) , and satisfaction improved with time ( @percent@ ) .
Patients reported high distress related to memories of anxiety / fear , delusions , restlessness , hypokinesia , and impaired orientation.
Patients reported improved psychological features and feeling.
Patients reported ongoing memory difficulties and performed below normative values on objective tests.
Patients reported significantly less pain than with conventional PDT and enjoyed the convenience of treatment generally in their backyard.
Patients reporting RMU demonstrated lower mental QOL and increased odds of low social engagement and un- or under-employment compared with nonusers.
Patients ' satisfaction and preference in treatment were also assessed.
Patients ' satisfaction and preference in treatment were also assessed.
Patients ' satisfaction score was graded as @number@ ( good ) in @percent@ ( @date@ ) of the patients.
Patient's satisfaction was recorded using a satisfaction questionnaire.
Patients ' satisfaction was significantly higher among subjects receiving Betesil® , if compared to patients receiving aescin @percent@ cream ( P < @number@ ) .
Patient's satisfaction with ICT-supported services is moderate to good.
Patients selected according to NINCDS-ADRDA criteria were classified using neuropsychological assessment tests.
Patients self-completed the WIQ , which was corrected with a nurse , if necessary , and then completed a treadmill test.
PATIENTS : Septic patients as identified by International Classification of Diseases , Ninth Revision codes using the Angus method.
PATIENTS : Seven hundred two consecutive mechanically ventilated ICU patients from @date@ to @date@ .
PATIENTS : Seventy nine men and women ranging in age from @number@ to @number@ years old.
Patients should be aware of this risk and receive counsel on modifiable risk factors.
Patients should be screened not only for bone density but also assessed for their nutritional status , physical activity , and drug intake.
Patients started COS with human menopausal gonadotropin ( hMG ) on day three of the menstrual cycle.
PATIENTS : Study was carried out on @number@ ASA I-II physicians 30-50yr.
Patients suffer from degeneration of the peripheral nerves that control sensory information of the foot / leg and hand / arm.
Patients taking atypical antipsychotics were matched with patients taking typical antipsychotics using the Greedy @number@ → @number@ matching technique.
Patients that were treated with LVAD had a worse risk profile in comparison with HTx patients.
PATIENTS : Thirty-one patients aged between @number@ and @number@ years , with a body mass index ≥25 kg / m and mild-to-moderate knee OA.
Patients : Thirty-one patients with moderate to severe OSA acclimated to CPAP.
Patients ' time and travel costs were similar.
Patients tolerated the treatments well and were satisfied with the clinical results.
Patients took a median of @number@ medications ( IQR @number@ @number@ ) .
Patients to whom auditory training programs are recommended often do not complete the training , however.
PATIENT ( S ) : Training cohort of @number@ infertile women.
Patients treated with PCI for AMI in the years @number@ to @date@ were studied.
PATIENTS : Twenty-eight patients with unilateral CAA were enrolled.
PATIENTS : Two hundred twelve healthy subjects with no history of vestibular or neurologic impairment.
Patient subitem scores , which ranked their feelings of depression , hostility , and inferiority , were summed to determine their 3-BSRS-subitem sum scores.
PATIENT SUMMARY : Bladder underactivity is an underresearched but important cause of urinary symptoms in men and women.
PATIENT SUMMARY : In this report , we assessed whether established PCa risk variants could predict PCSM.
PATIENT SUMMARY : Older women with UI demonstrate different problems with their pelvic organ support structures depending on the type of UI.
Patients undergoing aortic valve replacement for aortic stenosis ( AS ) incur an exceptionally high risk for perioperative cerebral ischemia.
Patients undergoing LDP had lower blood loss , first flatus time , diet start time and postoperative hospital stay.
Patients undergoing nonemergent general surgical operations were studied.
Patients underwent a full urogynaecological workup with a clinical evaluation and urodynamic study.
Patients underwent an extensive neuropsychological assessment.
Patients underwent B-mode ultrasound scan ( US ) for determination of IMT of the distal third of the common carotid arteries.
Patients underwent chemical peel or laser facial resurfacing and were randomized to the Obagi Nu-Derm System or a standard care regimen.
Patients underwent clinical assessment of their FC and cognitive function as well as objective testing of their attention.
Patients underwent conservative surgery followed by whole-breast radiotherapy.
Patients underwent follow-up via weekly telephone contact for @number@ months or until time of fall or death.
Patients underwent general and neurologic evaluation , and video-EEG recordings.
Patients underwent HCT between @number@ and @number@ in @number@ centers and were followed-up to @date@ .
Patients underwent two-dimensional echo-color Doppler scanning of the carotid arteries , adopting a high-definition vascular echographic apparatus and a 11-3 MHz linear electronic probe.
Patient survival at @number@ months was confirmed with the county death registry.
Patient survival was checked annually until @date@ .
Patients used a visual analogue scale to score characteristics of their scars.
Patients usually are satisfied with the final postoperative results.
Patients walked an average of about @number@ steps / day at baseline.
Patients were advised to apply @number@ drop @number@ times daily in both eyes.
Patients were aged at least @number@ years and were currently taking , or in the past @number@ years had taken , an NSAID for osteoarthritis.
Patients were all discharged at maximum @number@ h from the procedure.
Patients were allowed their established painkillers on demand.
Patients were also divided into @number@ or @number@ age groups.
Patients were also stratified analyzed according to stone components ( calcium oxalate stones [ COS ] ; non-calcium oxalate stones [ NCOS ] ) .
Patients were analyzed depending on AF in the resting electrocardiogram at hospital entry.
Patients were analyzed descriptively.
Patients were asked about shoulder symptoms and self-assessed health and completed the Stanford Modified Health Assessment Questionnaire.
Patients were asked to rate the pain felt at intervals during the procedure.
Patients were asked whether they would prefer to be in a shared room or a single room and to explain the reason behind their choice.
Patients were assessed at baseline and at @number@ @number@ @number@ and @number@ months after treatment.
Patients were assessed before surgery and at @number@ months.
Patients were assessed preoperatively and daily during hospitalization for delirium.
Patients were assessed twice using a Greek translation of the SIB and the Greek version of MMSE.
Patients were assessed with the Camberwell Assessment of Need for the Elderly / CANE.
Patients were assigned a socioeconomic status according to the district of residence at diagnosis.
Patients were assigned to one of three groups according to the type of laser treatment they received.
Patients were assigned to the intervention group ( n = 206 ) or control group ( n = 202 ) .
Patients were categorised as non-adherent if their mean adherence rate for all drugs consumed was < 80 %.
Patients were categorized according to KDIGO staging I to V , using the eGFR calculated with the CKD-EPI equation.
Patients were categorized as older ( ≥60 years ) or younger ( 18-59 years of age ) .
Patients were categorized by Fitzpatrick skin type ( I-IV ) to determine whether skin type was related to the frequency of complications.
Patients were categorized by ln ( CAC score ) quartiles.
Patients were categorized by malnutrition risk by MUST and MNA-SF.
Patients were categorized in three age groups : < 30 years , from @number@ to @number@ years , and > 60 years of age.
Patients were categorized into three groups ( < 60 , 60-74 , and ≥75 years old ) to analyze postoperative outcomes and 1-year mortality.
Patients were classified at the time of echocardiography into four filling patterns : normal , abnormal relaxation , pseudonormal , and restrictive filling.
Patients were classified into complicated , intermediate , and uncomplicated clinical trajectories.
Patients were classified into the five K / DOQI stages of CKD and median NT-proBNP values were calculated evaluating their relationship with GFR.
Patients were classified into two groups according to the use of postoperative medications.
Patients were classified with potentially inappropriate use of antimuscarinic OAB drugs based on either the @number@ Beers Criteria or the @number@ Beers Criteria.
Patients were clinically assessed with the revised Geneva scores.
Patients were confirmed to have PD ( modified Hoehn-Yars scale : @number@.075±0.4 ) who had undergone levodopa or dopamine agonist treatment.
Patients were consecutively admitted for acute care from @date@ to @date@ .
Patients were consecutively recruited from the outpatient clinic of the first Neurology Department of Athens National University at Aeginition Hospital.
Patients were discharged the same day ( SDD group ) or had at least one overnight stay ( non-SDD group ) .
Patients were divided according to clinical findings and the findings from brain computed tomography.
Patients were divided in age quartiles.
Patients were divided into five groups according to spike location in the frontal , central , temporal , occipital , or multiple cortical regions.
Patients were divided into four groups according to BMI quartiles.
Patients were divided into @number@ groups according to their age : Group @number@ ( ≤45-years-old ) and Group @number@ ( > 45-years-old ) .
Patients were divided into the ampicillin / sulbactam ( ABPC / SBT ) and AZM ( intravenous injection ) groups.
Patients were divided into three cohorts : ages 18-30 , 31-49 , and ≥50.
Patients were divided into three groups : young , middle age and old.
Patients were divided into two age groups according to the median age of @number@ years.
Patients were divided into two groups.
Patients were divided into two groups according to age ( below and above @number@ years ) .
Patients were divided into two groups according to IIEF scores , namely ' mild / no ED ' and ' moderate / severe ED'.
Patients were divided into two groups according to their symptom duration : group @number@ < 1 month ; and group @number@ 1-3 months.
Patients were divided into two groups : adults ( < 65 years , A ) , and aged ( ≥65 years , O ) .
Patients were divided into two groups to show age impact ; Group @number@ = 50-79 years old and Group @number@ = @number@ years and older.
Patients were divided into WMH severity tertiles based on pretransplantation WMH volumes.
Patients were divided in two groups considering @number@ years as cutoff to individuate the elderly patients.
Patients were evaluated at @number@ @number@ @number@ @number@ @number@ and @number@ days after the operation.
Patients were evaluated for global cognitive impairment , extrapyramidal signs , fluctuations of attention , and behavioral disorders.
Patients were evaluated @number@ months postoperatively and photographed.
Patients were examined at baseline ( when AMD was diagnosed ) and monthly thereafter.
Patients were excluded in case of a pathological or a periprosthetic hip fracture , multiple traumatic injuries , and high-energy trauma.
Patients were followed beginning at age @number@ years during a study period from @date@ to @date@ ( n = 265 ) .
Patients were followed for one-year to evaluate the recurrence of pneumonia and characteristics associated with RP.
Patients were followed for up to @number@ years and had cause-specific and all-cause mortality determined.
Patients were followed postoperatively during a mean period of @number@ months ( range , 15-36 months ) .
Patients were followed-up for @number@ days for MACE and MACCE.
Patients were followed up for @number@ months.
Patients were followed up in five groups : oxybutynin , darifenacin , tolterodine , trospium , and control groups.
Patients were followed up over @number@ months.
Patients were followed-up until death or censored at the end of the study ( @date@ ) .
Patients were followed yearly by the same team.
Patients were found with no more than @number@ GGGGCC repeats.
Patients were given a \ "clinical risk \ " level using their Risser sign and Cobb angle.
Patients were grouped according to the type of fracture ( intracapsular and extracapsular ) for calculation of the total blood loss ( TBL ) .
Patients were included if they had a diagnosis of Alzheimer's disease and were newly initiated on either rivastigmine or donepezil.
Patients were inhabitants of Primorsko-Goranska County.
Patients were initially recruited via their general practitioners ( GPs ) .
Patients were interviewed at home and by telephone.
Patients were interviewed during their outpatient visit.
Patients were investigated for microvascular and macrovascular complications.
Patients were mailed a baseline self-completion questionnaire , which included the question , ' What do you think caused your PMR ? '.
Patients were mainly female ( @percent@ ) , and middle-aged ( mean age @number@ years old ) .
Patients were matched in a 1 : 3 ratio with controls from the CINECA ARNO database.
Patients were monitored for HAI for @number@ months or until discharge from the geriatric unit or death.
Patients were monitored for @number@ ± @number@ months.
Patients were offered high-resolution ultrasound imaging to follow up their treatment.
Patients were partitioned into diabetic and nondiabetic groups and then further partitioned by sex to form four groups.
Patients were photographed before and immediately after injection to evaluate aesthetic outcomes.
Patients were physically less active ; a reduction of @percent@ compared to controls ( @percent@ CI , 10-44% ) .
Patients were predominantly female ( @number@ @percent@ ) and white ( @number@ @percent@ ) .
Patients were predominately male ( @percent@ ) , with mean age @number@ years.
Patients were prescribed a median of @number@ different therapeutic subgroups ( P25 = 6 and P75 = 11 ) .
Patients were prescribed OXN-PR at an initial dose of @date@ mg / day for @number@ days.
Patients were randomized to either oxycodone DETERx or placebo using a blocked randomization scheme in a 1 : 1 ratio.
Patients were randomized using computer generated random number table.
Patients were randomly assigned to receive PNF or conventional physiotherapy.
Patients were randomly assigned to receive solanezumab at a dose of @number@ mg or placebo intravenously every @number@ weeks for @number@ weeks.
Patients were randomly divided into a RACP group ( n = 77 ) and a SNP group ( n = 91 ) .
Patients were recruited and randomly assigned for six months to either telemonitoring or standard care.
Patients were recruited by advertisements in local regional newspapers and via the Internet.
Patients were recruited from @date@ to @date@ in order to have patients with at least one year of potential follow-up.
Patients were recruited from eight hospitals in the province of Quebec , Canada.
Patients were recruited from six Dutch community pharmacies.
Patients were recruited from the German city of Hamburg and the state of North Rhine-Westphalia.
Patients were referred with recurrent falls or orthostatic intolerance.
Patients were scored on the expanded disability status scale ( EDSS ) and MS Functional Composite ( MSFC ) at each time-point.
Patients were selected based on pre-defined criteria extracted from a comprehensive electronic medical record.
Patients were separated into @number@ groups according to the presence of mild cognitive impairment ( MCI ) .
Patients were separated into one of the following three groups : HbSS , HbSC , and control.
Patients were separated into two age-dependent groups ; middle-aged ( n = @number@ ) and elderly ( n = @number@ ) .
Patients were separated into two age groups : A ages @number@ and under , and over age @number@
Patients were stratified based on the presence or absence of concomitant HCV infection.
Patients were stratified into groups according to their age at IOL implantation for analysis.
Patients were stratified into : nonfrail , TSFI ≤ @number@ prefrail , TSFI = @number@ to @number@ and frail , TSFI > @number@
Patients were stratified into younger ( @number@ to @number@ years ) and older ( ≥65 years ) groups.
Patients were subdivided by the presence of + / - cataplexy and + / - hypocretin-1 deficiency.
Patients were subdivided in age groups ( 15-49 , 50-64 , 65-79 and ≥ @number@ years ) and calendar year.
Patients were surveyed preoperatively and postoperatively at intervals of @number@ @number@ @number@ @number@ and @number@ weeks.
Patients were surveyed regarding their perceptions of psychosocial needs and experiences as a cancer patient.
Patients were tested preoperatively and @number@ days postoperatively.
Patients were then administered with PEG-IFN / RBV therapy for @number@ weeks.
Patients were then clinically followed-up for @number@ years.
Patients were thus stratified according to Hunt-Hess grade on admission and evaluated at @number@ months using the Glasgow Outcome Scale ( GOS ) .
Patients were tracked from the time they were admitted to AIP or HHC until they were discharged.
Patients were treated by single-agent cetuximab.
Patients were treated in acute ( 8-12 weeks ) and long-term ( @number@ weeks ) studies.
Patients were treated until recovery , defined as the production of two consecutive normal stools or no stool production for a period of @number@ h.
Patients were treated with intravenous thrombolytic agents , or underwent intraarterial thrombolysis if their international normalized ratio ( INR ) was ≤1.7.
Patients were treated with palliative purposes for painful bone metastases.
Patients who achieved and did not achieve VT were compared , as well as the workload that VT occurred in the former group.
Patients who are frail or pre-frail have elevated long-term all-cause and breast cancer mortality.
Patients who commence PN already depleted in selenium may require more.
Patients who died showed significantly lower serum levels of total , free and bioavailable testosterone than those found in patients who survived.
Patients who exhibit fructose malabsorption can present with gastrointestinal symptoms that include chronic diarrhea and abdominal pain.
Patients who had diabetes-related co-morbidities had significantly less dispensing of metformin monotherapy and more dispensing of insulin than those without these conditions.
Patients who had received any medications within the last @number@ months that could alter bone metabolism were excluded.
Patients who meet these criteria should further undergo body composition assessment using dual energy x-ray absorptiometry with sarcopenia being defined using currently validated definitions.
Patients who produced a low GDS score were given a high rating by the clinicians.
Patients who received calcifediol were also given an exercise programme.
Patients who received clinical fluoride treatments had 17-20% decreased odds of requiring a restoration during the follow-up period.
Patients who received placebo declined as expected.
Patients who received PNB had more postoperative delirium ( P = 0.027 ) .
Patients who reported having ED had an average SF-36 score of @percent@ less than those without ED ( p < @number@ ) .
Patients whose caregivers experienced the highest burden were more likely to be non-White males without 24-hr paid homecare.
Patients who switch to a higher or lower level of drinking experience a similar alteration in their depressive symptoms.
Patients who undergo emergent orthopedic surgery are therefore at greater risk of perioperative cardiac events than those who undergo elective surgery.
Patients who underwent an episode of delirium were at increased risk for adverse outcomes.
Patients who underwent corrective fusion surgery for ASD between @number@ and @number@ were included.
Patients who were retained for the analysis were those for whom maintenance dosages were obtained for both vitamin K antagonists.
Patients will attend study visits at baseline , year @number@ @number@ @number@ and @number@
Patients will be eligible for the trial if they have been admitted to a participating ward and are aged @number@ years or over.
Patients with a BMI of @number@ kg / m or greater had the thickest LF at the L3-L4 level ( P < @number@ ) .
Patients with abnormal sleep had lower 24-h melatonin secretion compared to controls and patients with normal sleep.
Patients with abnormal tests of ovarian reserve have a poorer prognosis and may need more expedited and aggressive treatment.
Patients with acute confusional states ( often referred to as encephalopathy or delirium ) pose diagnostic and management challenges for treating physicians.
Patients with acute renal failure were excluded.
Patients with a del ( 17p ) or TP53 mutation can be treated with ibrutinib , venetoclax , or a combination of idelalisib and rituximab.
Patients with a diagnosis of Mild Cognitive Impairment who attended for routine annual assessment were asked to participate in the study.
Patients with ADRD and their older caregivers are also exposed to a higher risk of developing drug-related problems.
Patients with adult onset of symptoms are more prone to exhibit choreic movements whereas those with juvenile onset tend to develop parkinsonism or rigidity.
Patients with AD were significantly less accurate than age-matched controls , and older participants were less accurate than young observers.
Patients with AF are at increased risk of thromboembolism and ischemic stroke.
Patients with AF diagnosed concomitantly with hyperthyroidism were identified.
Patients with AFFs were predominantly female ( @percent@ ) and @percent@ had been taking oral bisphosphonate.
Patients with AF on admission ECG or known history of AF were excluded from analysis.
Patients with a KPS of ≥ @number@ derived the most benefit from therapy.
Patients with alcohol-related liver disease had a significantly lower rate of employment than did those with other etiologies of liver disease.
Patients with ALS performed worse in global cognitive functioning and executive and verbal memory tests ( p < @number@ ) .
Patients with Alzheimer's disease ( AD ) , a common dementia among the aging population , often also suffer from depression.
Patients with Alzheimer's disease ( AD ) or dementia are increasing in numbers as the population worldwide ages.
Patients with Alzheimer's disease can present with different clinical phenotypes.
Patients with Alzheimer's disease were compared to a healthy age-matched control group.
Patients with aMCI were impaired in the first-person view but not in the overhead view version.
Patients with a modified frailty index of @number@ or greater have increased risk for mortality at @number@ and @number@ years.
Patients with an activation mutation of the Lrp5 gene exhibit high bone mass ( HBM ) .
Patients with and without NMU did not differ on HIV status or SF-12 Physical Component Summary.
Patients with an implantable device have a 50-75% chance of having a clinical indication for MRI during the lifetime of their device.
Patients with a normal EEG presented with a cognitive profile in which memory was mostly impaired.
Patients with antemortem DTI studies and a range of AD pathology at autopsy were included.
Patients with aortic stenosis demonstrated regional differences in aortic distensibility with lower distensibility demonstrated in the proximal ascending aorta compared to an age-matched cohort.
Patients with a positive history of VTE were excluded.
Patients with atrial fibrillation should receive an effective oral anticoagulatory therapy when there are certain risk factors.
Patients with autoantibodies against FVIII often have severe hemorrhage and delayed diagnosis can contribute to high mortality in these patients.
Patients with baseline diffusion-weighted magnetic resonance imaging and follow-up diffusion-weighted imaging or computed tomographic scan were included to evaluate the final infarct volume.
Patients with better communication abilities seemed to benefit more from the LSWp.
Patients with bipolar disorder ( BD ) are at high risk for developing cardiovascular diseases ( CVDs ) during aging process.
Patients with bone metastasis were categorized into two groups.
Patients with CAC < @number@ had better renal function and a lower cardiovascular risk profile.
Patients with CAC > @number@ were older and more likely to be men , diabetic , and overweight.
Patients with cardiovascular disease have more brain atrophy and a higher morbidity and mortality.
Patients with caregivers in the \ "moderate \ " group likewise performed better than those in the \ "poor \ " group.
Patients with cataplexy had a significantly higher frequency of sleep-wake transitions ( P = @number@ ) than those without cataplexy.
Patients with CAVB were more likely to present with cardiogenic shock , and CAVB was caused primarily by right coronary artery occlusion.
Patients with CAVD need to cope with a deteriorating quality of life and valve replacement is the only effective clinical option for the patients.
Patients with ccRCC who were more than @number@ years old showed significantly higher MVD than their younger ( < @number@ years ) counterparts.
Patients with central losses exhibit greater instability with the addition of a secondary task , particularly during somatosensory perturbations.
Patients with cerebral palsy ( CP ) have significantly lower caloric requirements than anticipated using predictive equations.
Patients with CHA2 DS2 -VASc of @number@ did not develop stroke.
Patients with CHA ( @number@ ) DS ( @number@ ) -VASc≥2 were selected.
Patients with chronic HCV infection were at higher risk to develop abnormal liver tests.
Patients with chronic kidney disease ( CKD ) display a progeric vascular phenotype linked to apoptosis , cellular senescence and osteogenic transformation.
Patients with chronic obstructive pulmonary disease ( COPD ) have abnormal circadian rhythms , reflected by daily changes in respiratory symptoms and lung function.
Patients with chronic spontaneous urticaria according to the EAACI / GA2LEN / EDF / WAO guidelines were included.
Patients with CKD had a greater Treatment Intensity Score ( p < 0.001 ) in the absence of a significantly greater BP control.
Patients with CKD have significantly higher bone marrow fat than healthy adults ; the relationship with bone changes requires further analyses.
Patients with classical cardiovascular risk factors had Frank's sign at a higher frequency.
Patients with classical HCM , acute myocardial infarction , stress induced cardiomyopathy or unstable hemodynamics which potentially induce transient-DLVOTO were excluded.
Patients with classic disease had reductions of volume in the ventral striatum and prefrontal areas compared with those with the variant form.
Patients with coexistent proteinuria and reduced eGFR were at the highest risk of poor outcome and death.
Patients with concomitant C-spine and RTC diagnoses were then stratified by age group and sex.
Patients with concurrent GERD were younger , had shorter duration of DM , and were taller and heavier.
Patients with congenital adrenal hyperplasia ( CAH ) with tenascin-X deficiency ( CAH-X syndrome ) have both endocrine imbalances and characteristic Ehlers Danlos syndrome phenotypes.
Patients with constipation or snoring demonstrated a reduced recovery rate.
Patients with contraindications to indicated medicines are more frequently under-treated.
Patients with COPD had significantly shorter 6-min walking distance ( @number@ ± @number@ vs @number@ ± @number@ m , p < 0.05 ) .
Patients with CP pose a particular challenge in nutrition assessment.
Patients with CRS may require medical management and surgical treatment for alleviation of their olfactory dysfunction.
Patients with CSA show endothelial dysfunction.
Patients with Cushing disease and syndrome develop a depressive syndrome : irritable and depressed mood , decreased libido , disrupted sleep and cognitive decrements.
Patients with cutaneous malignancies often require multidisciplinary care.
Patients with darker skin types ( Fitzpatrick skin types IV-VI ) face unique challenges for successful facial skin resurfacing.
Patients with dementia due to Alzheimer's disease ( AD ) have increased risk of developing delirium.
Patients with dementia had significantly higher mean error scores than patients without dementia.
Patients with dementia have poorer health outcomes , longer hospital stays , and higher rates of readmissions and institutionalization.
Patients with dementia or Cockayne syndrome had a higher GlycoAgeTest level than age-matched healthy individuals.
Patients with dementia ( P < 0.001 ) had a higher risk of acute delirium after both CD and CF.
Patients with depression were at a higher risk of ED ( aHR : @number@ @percent@ CI : @number@.49-2.63 ) compared with the subjects without depression.
Patients with diabetes experience a roughly 20-25% higher cancer incidence compared to individuals without diabetes , and it depends on cancer site.
Patients with diabetes have approximately twice the risk of stroke compared to nondiabetics.
Patients with diabetes or renal impairment were associated with a higher cost of HFpEF management.
Patients with disturbed basal ganglia function such as Parkinson׳s disease ( PD ) showed development of discourse comprehension deficits evoked by lexical ambiguity.
Patients with Down syndrome ( DS ) invariably develop Alzheimer's disease ( AD ) pathology in their 40s.
Patients with excellent performance status and low comorbidity have the best long-term survival after HCT.
Patients with facial lipoatrophy related to HIV were excluded from this evaluation.
Patients with fasting plasma glucose levels > @number@ mg / dL had a @number@.8-fold increased risk of developing hyperlactemia.
Patients with focal and diffuse EEG abnormalities presented with a nonmemory profile.
Patients with fracture in @number@ of @number@ bones were significantly more likely to die within one year of fracture ( p < 0.0001 ) .
Patients with fracture who used LIPUS had a @percent@ HR , whereas the expected HR averages @percent@.
Patients with FTD were correctly attributed to a diagnosis of FTLD with a sensitivity of @percent@.
Patients with ginkgo aglucone flavone indications are selected for experiment.
Patients with good postoperative hearing ( < 40 dBHL ) showed better sound localization results.
Patients with gout were indexed at first gout diagnosis or prescription over the study period @date@ , to @date@ .
Patients with haemophilia are growing older and may be faced with age-dependent co-morbidities.
Patients with HCM are at increased risk of sudden cardiac death ( SCD ) and developing rhythm disorders.
Patients with HCV who had at least one physician visit in a given calendar year were included in the analysis of prevalence for that year.
Patients with head and neck cancer experience significant treatment-related symptoms.
Patients with healed fracture ( age @number@.0±12.7SD ) were older ( p < 0.0001 ) than patients with nonunion ( age @number@.2±13.4SD ) .
Patients with heart failure and receiving benzodiazepines were identified as barriers of recognition of delirium.
Patients with high ERA scores undergoing coronary revascularization were also at the highest risk of mortality.
Patients with higher high-sensitivity cardiac troponin T or insular cortex involvement may be candidates for prolonged ECG monitoring.
Patients with high VASH1 expression in tumour had significantly shorter disease-free survival and more frequently had lymph node recurrence than those with low VASH1 expression.
Patients with hip fractures at our institution historically were admitted to multiple different services and units , leading to unnecessary variation in inpatient care.
Patients with Hirayama disease generally show minimal sensory signs and no pyramidal signs.
Patients with HS-Aging live considerably longer than patients with non-tauopathy FTLD.
Patients with hypogonadism reported a higher prevalence of erectile dysfunction after LDLT than patients without hypogonadism ( p < @number@ ) .
Patients with INAD usually show neurological symptoms with infant onset and die in childhood.
Patients with infection , sepsis , immunodeficiency , or concomitant immunosuppressive therapy were excluded.
Patients with internal disc disruption were significantly younger than those with facet joint pain or sacroiliac joint pain.
Patients with IS were older and had more significant preoperative risk factors and comorbidities.
Patients with klotho-expressing tumors had longer survival periods than did those with klotho-negative tumors.
Patients with knee osteoarthritis ( OA ) are often complicated with joint soreness , swelling , weakness , and pain.
Patients with less subjective memory disturbances before ECT had a greater risk of SMW.
Patients with logopenic variant primary progressive aphasia also showed significant hypersynchrony of delta-theta frequency within bilateral medial frontal and posterior parietal cortices.
Patients with lower eGFRs had a higher frequency of INR ≥ @number@ ( P < 0.001 ) .
Patients with lower lid laxity , prior surgery , trauma , significant excess skin , or festoons were excluded.
Patients with low perceived social support combined with a low education level was a particularly vulnerable group.
Patients with LPL deficiency and severe or recurrent pancreatitis are eligible for the first gene therapy treatment approved by the European Union.
Patients with major cranial abnormalities ( brain tumors , hyperacute or acute ischemia , developmental anomalies , hemorrhage , hydrocephaly ) were excluded.
Patients with malignant effusion had the highest mortality followed by multiple benign aetiologies , congestive heart failure and renal failure.
Patients with mastocytosis display high level of negative emotionality such as depression and stress sensibility.
Patients with MCI did not differ from healthy aging on any measure of sleep-disordered breathing or sleep fragmentation.
Patients with MCI may present minor impairments in activities of daily living ( ADL ) .
Patients with MCI with a middle or high level of education more often got a false negative assignment than patients with a low educational level.
Patients with methylated O ( @number@ ) -alkylguanine deoxyribonucleic acid alkyltransferase promoter seem to have better outcomes.
Patients with Mild Cognitive Impairment have a higher risk of progression to dementia.
Patients with ModATPIII had lower mPSV when compared to non-MetS patients ( @number@ versus @number@ p < @number@ ) .
Patients with moderate risk received additionally orientation guidance , and mobility restriction.
Patients with moderate to severe mitral stenosis or mechanical heart valves were excluded from the trial.
Patients with more severe physical disability and a more rapid rate of disease progression had increased sensorimotor connectivity values.
Patients with more severe rhytides and those older than @number@ years of age showed the best clinical results.
Patients with MPS-I have been reported to present with various clinical phenotypes and severities even if they have identical mutations of IDUA.
Patients with mutations involving the telomerase complex may present with pulmonary fibrosis , hematologic , cutaneous or liver diseases.
Patients with NAR were older and predominantly female.
Patients with NCDs will be referred to the chronic disease clinic of the hospital by a primary care physician.
Patients with no insurance or Medicaid have lower survival expectations after diagnosis with AML than patients with other insurance.
Patients with @number@ or more rare variants had lower probability of survival than patients with @number@ or @number@ variant ( p = @number@ ) .
Patients with OA with haplogroup H showed higher serum levels of MMP-3 than healthy controls.
Patients with OCT mean RNFL thickness > 65 μm and mean macular ganglion cell complex thickness > 55 μm had better visual outcomes.
Patients with other conditions that could affect functional status or compression factors other than spondylosis were excluded from this study.
Patients without respiratory problems constituted @percent@ of the entire group.
Patients without the APOE-ε4 allele showed better treatment effects than those with this allele.
Patients with painful bladder syndrome , mixed stress and urge incontinence , prolapse , or recent pelvic surgery were excluded.
Patients with pancreatic cancer had less muscle mass than patients with biliary tract and colorectal cancers ( P < @number@ ) .
Patients with Parkinson's disease ( PD ) are likely to become physically inactive , because of their motor , mental , and emotional symptoms.
Patients with paroxysmal AF have been enrolled in a randomized , prospective , double-blind , controlled placebo trial.
Patients with PCa showed higher androgens and lower adiponectin than Controls.
Patients with PD and AP had significantly higher rates of health-related contact and medication use and a higher socioeconomic cost.
Patients with PD / DLB are at high risk of developing complications during hospital admission for hip fracture.
Patients with phenylketonuria ( PKU ) encompass an ' at risk ' group for micronutrient imbalances.
Patients with Phenylketonuria ( PKU ) reportedly have decreased bone mineral density ( BMD ) .
Patients with positive pelvic LN were @percent@ and @percent@ , in SLN and LD groups , respectively ( p = 0.002 ) .
Patients with possible abnormal findings are scheduled for a face-to-face examination in the eye clinic.
Patients with PreCI had a significantly increased incidence of POCD at @number@ days and @number@ months and cognitive decline at @number@ months.
Patients with prion diseases can live for long periods of time in a state of akinetic mutism given appropriate management of their symptoms.
Patients with prior use of memantine and / or antipsychotics were excluded.
Patients with prosthetic joint infections were excluded from the study.
Patients with pseudophakic eye were used as control.
Patients with PS @number@ or who received palliative-intent chemotherapy or had multiple comorbidities were more likely to discontinue chemotherapy because of toxicity.
Patients with psychiatric symptoms , such as depression and hallucinations , were more likely to have dementia.
Patients with pulmonary regurgitation ( PR ) and right ventricular ( RV ) volume overload have systolic septal motion toward the RV.
Patients with RA aged < 50 years experience an independent adiposity-driven leptin-endothelial activation relationship in the absence of leptin-metabolic risk factor associations.
Patients with renal disease were more likely to have glitazones dispensed ( RR = 1.46 , @percent@ CI : @number@ @date@ ) .
Patients with renal failure have a life-long requirement for a durable form of hemodialysis vascular access.
Patients with renal or hepatic disease were excluded.
Patients with right MTLE showed almost no significant functional connectivity.
Patients with SAM had profiles that were profoundly different from those of stunted and nonstunted controls , even after clinical stabilization.
Patients with sarcoidosis above @number@ years of age had significantly higher percentages of neutrophils in BALF compared with younger patients.
Patients with secondary RLS other than iron deficiency were excluded.
Patients with severe AIBD had significantly more impairment that those with mild ( P < .001 ) and moderate ( P = .002 ) AIBD.
Patients with severe mental illness had high levels of sedentary behaviours , with watching television being the most prevalently reported.
Patients with severe motor and intellectual disabilities ( SMID ) often suffer from autonomic nervous system disturbances.
Patients with severe phenotypes have mostly mutations leading to premature termination codon ( PTC ) and / or splice-site or missense mutations.
Patients with severe psoriasis may be at an increased risk for myocardial infarction and this subgroup of patients tends to have a reduced life expectancy.
Patients with significant facial atrophy and age-related loss of facial fat generally achieve suboptimal improvement from both surface treatments of facial skin and surgical lifts.
Patients with significant valvular disorder were excluded.
Patients with skin of color have similar skin care needs as lighter-skin patients.
Patients with sleep disturbances had more significantly impaired QoL affecting all domains than those without.
Patients with SOD1 mutations revealed a significant reduction of TDP-43 in the nuclei without cytoplasmic mislocalization.
Patients with STEMI and NSTEMI were more inclined to be increasingly treated by invasive treatments with percutaneous coronary intervention.
Patients with such fracture must receive high priority for optimal post fracture treatment.
Patients with suspected TIA and minor stroke with early spontaneous recovery should be evaluated as soon as possible after an event.
Patients with T1D , GD , RA and healthy controls were genotyped for the @number@ C / T SNP in PTPN22 gene.
Patients with the D816VC KIT mutation who had high perceived stress scores displayed significantly shorter telomere but not if they had high depression scores.
Patients with the main clinical phenotypes of multiple sclerosis ( MS ) manifest varying degrees of brain atrophy beyond that of normal aging.
Patients with the milder phenotypes have mostly glycine or arginine substitutions associated or not with other types of mutations.
Patients with these characteristics are described as frail and suffer increased adverse clinical outcomes.
Patients with these two components of metabolic syndrome are often overweight or obese.
Patients with this syndrome have severe symptoms of exercise intolerance , frequent hospitalizations , and increased mortality.
Patients with treated HIV-1-infection experience earlier occurrence of aging-associated diseases , raising speculation that HIV-1-infection , or antiretroviral treatment , may accelerate aging.
Patients with type @number@ diabetes are at increased risk of age-related cognitive decline and dementia.
Patients with type @number@ diabetes mellitus are characterized by increased incidence of cardiovascular events and enhanced thromboxane-dependent platelet activation.
Patients with xeroderma pigmentosum ( XP ) are extremely sun sensitive due to a genetic defect in components of the NER cascade.
PATIENT ( S ) : Women aged 18-40 years.
PATIENTS : Women aged @number@ years or older participated in the study.
PATIENTS : Women undergoing in vitro fertilization.
Patients wore a pedometer for @number@ days to assess daily activity.
PA tracking over @number@ years was low and non-significant , but moderate over the final @number@ years.
Pattern electroretinogram ( ERG ) , which reflects the function of retinal ganglion cells , dark-adapted ERG , and cone ERG were performed.
Pattern heterogeneity of CFLs suggests that tailored treatment may be warranted.
Pattern of diffusion tensor MRI ( DTI ) alterations were investigated in pathologically-staged Alzheimer's disease ( AD ) patients ( n = @number@ ) .
Patterns and consistencies of the lumbar postural changes were determined.
Patterns are similar for medical expenditures.
Patterns generally were consistent across age-groups ( 60-69 , 70-79 , and ≥80 years ) .
Patterns in IHC utilization and differences based on pathologist training and experience is understudied in the peer-reviewed literature.
Patterns may progress with age from central to lower fan or full fan.
Patterns of activity were characterized as bouts ( defined as the consecutive minutes within an intensity ) .
Patterns of cerebral asymmetry related to visuospatial functions may change with age.
Patterns of cerebral blood flow ( CBF ) and cognitive performance were compared.
Patterns of change must be replicated over longer periods of time.
Patterns of neural activation were assessed in anxious and non-anxious youth as they were cued to anticipate social feedback from peers.
Patterns of OAI were changing over time.
Patterns of progressive cortical thinning in dementia with Lewy bodies ( DLB ) remain poorly understood.
Patterns of sedentary time accumulation may vary and have differential health risks.
Patterns of use were then applied to the projected prevalence of cancer , using data from the SEER Program of the National Cancer Institute.
Patterns of WM were assessed using voxel-based morphometry.
Patterns related to specific symptoms were similar.
Patterns were generally consistent across different age groups ; where differences were seen , associations were stronger in younger age group.
Pattern switching was accompanied by concomitant changes in the variability of AT / DT ratio.
Paulette Guinchard-Kunstler has worked at the highest level to raise awareness of this issue.
PA was assessed through an interviewer-administered questionnaire at baseline and 3-year follow-up.
PA was assessed through a self-administrated questionnaire.
PA was rated with a questionnaire covering household-related and recreational activities.
( Pawson & Tilley , @number@ ) .
Payment concerns and lack of data on local health providers made deciding where to obtain services challenging.
Payors and policymakers trying to encourage generic use may consider educational campaigns targeting older physicians.
PBF and fat-free mass ( FFM ) were determined by dual energy X-ray absorptiometry.
PB farms own similar-sized rubber plantations and raise pigs , with fodder mainly being cultivated and collected in the forest.
Pb latency was shorter at Fz than at Cz.
Pb levels were measured from blood samples ( BPb ) of @number@ Brazilian individuals ( @number@ women ) , between @number@ and @number@ years old.
PC1 messenger RNA ( mRNA ) levels decreased upon UVA irradiation , but recovered in response to high doses of GEB in HDF.
PC2 consisted of measures of good metabolic and cardiovascular function with an estimated heritability of @percent@.
PC-3 and DU-145 cells express higher c-Myc , Skp2 , Akt , Akt1 , and phospho-EGFR but less phospho-Akt and phospho-ERK.
PC-3 is an androgen receptor ( AR ) -negative PCa cell line with high metastatic potential established from PCa bone metastasis.
PC3 was made up of cognitive measures ( h ( @number@ ) = @percent@ ) .
PC4 and PC5 contained measures of blood pressure and cholesterol , respectively ( h ( @number@ ) = @percent@ and @percent@ ) .
PCA identified ' pace' , ' variability' , and ' coordination ' as key properties of gait.
PCA identified six anterior factors peaking between ∼140 ms and @number@ ms , and four posterior factors peaking between ∼300 ms and @number@ ms.
PCA identified two factors , on which @number@ of the original @number@ items had loaded sufficiently to be eligible for inclusion in a short version.
PCA models were created for the knee joint forces , moments and angles about the three axes.
PCA of pooled neuroradiological and neurophysiological markers suggested that four components accounted for @percent@ of the total variability.
PCA resulted in defining @number@ independent PCs , explaining @percent@ of the total variability of bone characteristics.
PCA resulted in three components that explained @percent@ of data variance.
PCA transformation provided 2-D visualization and knowledge of variations among spinal features.
PCBs , a group of @number@ individual congeners , are ubiquitous environmental pollutants and classified as probable human carcinogens.
PCBs @number@ @number@ and CAM significantly reduced telomerase activity from days 18-48.
PCC has demonstrated the potential to improve preventive care for older adults with chronic diseases.
PC collaboration remains important in psychosocial support and coverage of dying AML patients in non-hospice settings.
PC counts were not associated with tremor duration ( r = @number@ @percent@ CI : @number@ @date@ ) .
PCD in peripheral blood lymphocytes was determined in sporadic AD patients and gender and age-matched unaffected controls.
PCD is defined as self-reported modification in any of four tasks without reporting difficulty in those tasks.
PCD is regulated by a balance of negative and positive factors , including the mitochondria , which are particularly subject to aging-associated malfunction.
PCD pathways limit life span in fungi , but whether PCD pathways normally limit adult metazoan life span is not yet clear.
PCE decreased endothelial expression of vascular endothelial growth factor ( VEGF ) and hypoxia inducible factor ( HIF ) -1α induced by HG-HRMC-CM.
PCE diminished the mesangial and endothelial induction of angiopoietin ( Angpt ) proteins under hypeglycemic conditions.
PC excels in restriction of antipsychotic use.
PcG-associated postnatal transcriptome change specific to the stem cell-like monocytes is found to be incompletely explained by conventional measures of PcG region structure.
PCI for elderly patients with ACS is safe and life saving , and does not reduce the ability to perform activities of daily living.
PCI should be recommended even for octo-nonagenerians with ACS.
PC linear density of the cerebellar hemisphere was calculated in a blinded manner.
PCNA + fibroblast percentage demonstrating their proliferative pool also reliably decreases with age.
PCOS is associated with oxidative stress , namely increased production of free radicals followed by decreased serum antioxidant levels and antioxidant enzyme activity.
PCOS is often diagnosed in puberty with the onset of hyperandrogenism and may be preceded by premature pubarche.
PCR cloning and nucleotide sequence analysis indicates that the NCT mouse has a nonsense nucleotide substitution at exon @number@ of the Oca2 gene.
PCR-restriction fragment length polymorphism was used at the 1377-bp site.
PCSK9 levels increase in females after menopause but not in men during this phase in life.
PCSK9 levels were @percent@ higher in postmenopausal than in premenopausal ( P < @number@ ) females.
PCTs improve performance only in cognitive tests similar to the training tasks with inconsistent transfer effects on dissimilar tests.
PCV remains etiologically uncharacterized , and ongoing discussion is whether PCV and neovascular AMD share the same etiology or constitute two substantially different diseases.
PD-1 / PD-L1 blockade appears to be a very promising immunotherapy with significant clinical benefits and durable responses in multiple tumor types.
PD5 animals also showed an upregulation of multiple inflammatory response genes and an activated NF-kB target pathway.
PDa could not be assessed on the raw images without preprocessing.
PD and AP have major socioeconomic consequences for patients and society.
PDa operates by evaluating signal-dependent noise ( SDN ) , captured as local signal variation.
PD-associated α-synuclein mutations increase α-synuclein binding to Tau and stimulate Tau phosphorylation at Ser ( @number@ ) .
PDa was applied to the raw and clinical display ( or processed ) representation images.
PDCD10 / CCM3 molecular screening revealed four already known mutations and four novel ones.
PDC had a standardized protocol that included assessment and reassessment , action planning , and ongoing monitoring.
PDDIs were analysed using a computerized program and categorized according to level of severity , onset , mechanism and documentation in the literature.
PDE11A4 is the PDE11A isoform expressed in brain and is found in the hippocampal formation of humans and rodents.
PDE11A4 likely controls behavior by regulating hippocampal glutamatergic , oxytocin , and cytokine signaling , as well as protein translation.
PDE11A is a dual-specific PDE , breaking down both cAMP and cGMP.
PD , gender and SSI were not significantly correlated with the three ALCC parameters.
PD group showed the characteristic gait deficits associated with PD.
PDH , which converts pyruvate to acetyl-CoA , has been known to be primarily regulated by phosphorylation of its E1 component.
PD in these samples was related to verbal fluency and education but not to working memory.
PD in written samples did not differ between participants with aMCI and control participants.
PD is a progressive disease , whose progression is linked to young age and to risk factors of fibrosis.
PD is characterized by a movement disorder from loss of nigrostriatal dopamine neurons.
PD is characterized by the combination of slowness of movement ( bradykinesia ) , muscular rigidity , resting tremor , and postural instability.
PD is triggered by genetic alterations , environmental / occupational exposures and aging.
PDLSC were isolated and cultured using a tissue-block-based enzymolytic method by limiting dilution assay.
PD medication use may influence CSF α-syn.
PD patients showed an absolute decrease in CB1 availability in the substantia nigra.
PD patients were examined using the Unified Parkinson's Disease Rating Scale ( UPDRS ) and the modified Abnormal Involuntary Movement Scale ( mAIMS ) .
PD progresses insidiously for 5-7 years ( preclinical period ) and then continues to worsen even under the symptomatic treatment.
PDPs vary in generosity through differences in medication coverage and utilization management.
PDT licensed indications in dermatology are actinic keratosis , Bowen's disease and superficial basal cell carcinomas.
PDT treatment of large areas can induce intense pain.
PD was identified in one NMC at age @number@ and in no control subjects.
PD with or without dementia has a core feature of longitudinal decline in visuospatial abilities.
Peak biting was @date@ @number@
Peak blood flow was assessed after a period of ischemia in the limbs to test endothelial function.
Peak COM accelerations prior to seat-off differed significantly among groups ; however , no significant differences were detected in its velocities at seat-off.
Peak expiratory flow rate ( PEFR ) is a measure of ventilatory capacity measured by peak flow meter.
Peak Flow and grip strength were significantly better in less-than-ten-year seniority in shift work group.
Peak FMD was defined as the greatest percent change from baseline to the peak brachial artery diameter following reactive hyperaemia.
Peak frequency and relative power of @number@ frequency bands were calculated.
Peak latency was significantly shorter and amplitude was significantly smaller in adults than younger and older children.
Peak nasal inspiratory flow ( PNIF ) is a cheap and easy method for assessing nasal patency.
Peak O2 uptake ( V˙O2peak ) and HRpeak were determined by a maximal exercise stress test using a bicycle ergometer.
Peak oxygen uptake , maximal workload , and ventilatory threshold were determined during a ramp protocol on a cycle ergometer.
Peak oxygen uptake on a treadmill yielded estimated midlife CRF in @number@ and late-life CRF in @number@ participants.
Peak oxygen uptake was measured by graded exercise test.
Peak power and peak force were not affected by a concurrent attention-demanding task.
Peak power was reduced by @percent@ and @percent@ at task termination in the old and young , respectively ( P < @number@ ) .
Peak strength was assessed for leg press , chest press , triceps , knee extension , and knee flexion.
Peaks were seen in the velocity curve at @number@ and @number@ years , but the MPV was presumed to be at @number@ years.
Peak tongue pressure was significantly lower in OAs than YAs both before and after meal consumption.
Peak-to-peak amplitudes of delta ( @number@.5-3Hz ) target ERO responses during the post-stimulus 0-800ms time window were measured.
Peak-trough measures yielded inconsistent results in relation to luminance.
Peak twitch torque ( P ( t ) ) was ~50% lower in the old at task termination , whereas the young were unchanged.
Peak twitch torque was reduced only for the older men and no changes in voluntary activation and M-wave properties were recorded in either group.
Peak velocity of the dominant hand was measured using three different loads of @number@ @number@ and @percent@ of maximum voluntary contraction ( MVC ) .
Peak VO2 and VE / VCO2 slope were not associated with left atrial structure or function.
PEAL also up-regulated TNF-related apoptosis-inducing ligand ( TRAIL ) receptor DR5 and down-regulated survivin and cellular inhibitor of apoptosis @number@ ( cIAP-1 ) .
PEAL inhibited cancer cell growth by inducing caspase-dependent apoptosis.
Pearson and Spearman correlation coefficients were used to examine correlations between personal characteristics and health literacy level.
Pearson and Spearman correlations and mixed models for correlated data were used for analysis.
Pearson coefficient was used to assess correlations.
Pearson correlation analysis revealed that SampEn in the sagittal plane significantly correlated with OLST ( CONCLUSION : Lower SampEn implies rigidity for postural control.
Pearson correlation analysis showed that the AUCage of HbA1c was negatively correlated with age ( r = @number@ P = @number@ ) .
Pearson correlation analysis was used to evaluate the age dependence of DTI metrics and iron concentration.
Pearson correlation and age-adjusted partial correlation analyses between body composition-related parameters and BMD were performed.
Pearson correlation and linear regression analyses were used.
Pearson correlation and multiple regression analysis were used to study the correlation of UA with BMD at various skeletal sites.
Pearson correlation and multivariate linear regression analysis was performed to assess the relationship between log ( neopterin ) and log ( IL-6 ) .
Pearson correlation coefficients and Multivarient linear regression show no significant correlation between MMSE and continuous variables in AD patients except for age.
Pearson correlation coefficients for all correlations between MMSE scores and hippocampus MK / MD values / volumes were significant.
Pearson correlation coefficients , linear , concordance correlation coefficient , and Blant Altman procedures were used to assess measurement , agreements between the two procedures.
Pearson correlation coefficients were calculated for the correlations between mini-mental state examination ( MMSE ) scores and MK / MD values / volumes.
Pearson correlations and analysis of variance were used to examine the relationship to demographic variables , and frequency of missed items was reviewed.
Pearson correlations were used to examine the relationships of nocturia with sleep quality and glycemic control.
Pearson partial correlations between body composition measures and metabolites were adjusted for age , study site , and smoking.
Pearson's correlation analysis revealed a negative correlation between t-Hcy and TAS ( p < 0.038 ) .
Pearson's correlation analysis showed that family functioning scores were correlated with Mini-Mental State Examination scores ( r = @number@ P = @number@ ) .
Pearson's correlation and linear regression analyses were used to determine the cross-sectional association between sociodemographic , interpersonal relationship and health variables with the scale.
Pearson's correlation coefficient and single regression analysis were used to assess the relationship between cartilage T1 rho values and age.
Pearson's correlation coefficient and the Mann-Whitney U test were used for the statistical analysis.
Pearson's correlation coefficient showed a high correlation between right and left eyes ( r = @number@ ( p < @number@ ) ) .
Pearson's correlation coefficients were calculated to explore associations between the scores on the HCS and cognitive function.
Pearson's correlation revealed that height had the strongest and weight had the weakest correlation with US measurements.
Pearson's correlations and linear regression models adjusted for age were calculated.
Pearson's correlation test was used to determine the relationship between hearing threshold and serum levels of retinol and zinc.
Pearson's correlation was used to assess the relationship between variables , and backward stepwise regression analysis was used to identify the outcome determinants.
Pearson's correlation was used to establish the relation between Body Mass Index and serum ferritin levels.
Pearson's r and distributed lags time series analysis between longevity indicators and GDPpc were conducted.
Pearson's χ ( @number@ ) -test , one-way anova and multiple linear regression were applied in statistical analysis.
PEC films could be exploited as a prolonged drug release devices for treatment of periodontal pockets.
Pediatric choroidal thickness is associated with several systemic or ocular parameters , especially the axial length and body mass index.
Pediatric choroidal thinning with increasing age in the central area was faster than that in the outer areas.
Pediatric Epstein-Barr virus ( EBV ) -positive diffuse large B-cell lymphoma ( EBV + DLBCL ) is a rare disease in nonimmunocompromised hosts.
Pediatricians have relied on methods for determining skeletal maturation for > 75 years.
Pediatric rheumatologists have dramatically increased in number in @number@ but @percent@ reside in @number@ countries.
Pediatric to adult effective dose ratios were also calculated with VirtualDose , and were compared with the ranges of effective dose ratios provided in ImPACT.
Pedicled perforator flaps will likely see increased application for facial reconstruction in the near future.
Pedicle screws are the implants used most commonly in spinal surgery for fixation , but their efficacy depends directly on bone quality.
Pedunculated shape was strikingly more common in participants with left- vs right-sided advanced neoplasia ( @percent@ vs @percent@ ) .
PEFR declines with advancing age due to degenerative changes in musculoskeletal system leading to decrease in respiratory muscle strength.
PEFR shows some decline with high BMI in elderly age group.
Pegvisomant supplementation had no effect on collagen synthesis in tendon and skeletal muscle , nor was muscle myofibrillar protein synthesis affected.
Pellet extrusion and polycythemia occurred in one patient each.
Pellet size / shape was monitored with time.
Pelvic and inguinal lymph nodes were metastatic.
Pelvic floor alterations during menopausal years , resulting from aging and hormonal decline , may lead to several forms of sexual dysfunction.
Pelvic floor dysfunction globally affects micturition , defecation and sexual activity.
Pelvic lymphadenectomy was performed in @percent@ and @percent@ in Monza and Rome , respectively ( p < 0.001 ) .
Pelvic movement during walking was compared between the two groups.
Pelvic organ prolapse , obstructed defecation , and fecal incontinence were associated with not enjoying sex.
Pelvic organ prolapse ( POP ) is a common , benign condition in women.
Pelvic organ prolapse ( POP ) is a common , benign condition in women.
Pelvic organ prolapse ( POP ) is a common , benign condition in women.
Pelvic organ prolapse ( POP ) is a common , benign condition in women.
Pelvic organs appeared normal , while right external iliac lymph nodes appeared enlarged ( maximum diameter = @number@ mm ) .
Pelvic suspension ( PS ) significantly decreased the WBSF of beef muscle at @number@ d and @number@ d postmortem compared with AS.
PEMA and PMMA demonstrated better color stability than the two bis-acrylic resin composites.
Pen-1 subjects were exposed to control-conditions for @number@ weeks with half receiving the antidepressant fluoxetine and the rest receiving saline-placebo.
Pen-2 is distributed much more extensively than extracellular amyloid deposits , suggesting the importance of other factors in localized amyloid deposition.
Pen-2 is localized predominantly in cell membrane and cytoplasma in adult AD mice , but only distributed at cell membrane in controls.
Pen-2 subjects were exposed to @number@ weeks of separation-stress with half receiving fluoxetine and half receiving placebo.
Penalization proved to be less computationally intensive than an analogous Bayesian analysis by a factor of @number@
Penalized spline identified those who lost more than about three kg or gained more than about @number@ kg as having increased risk of death.
Pending such studies , testosterone therapy should be considered in androgen-deficient men , with evaluation of potential benefits and risks.
Penetration studies were conducted on excised full thickness human skin in Franz type diffusion cells for @number@ and @number@ hours.
Penetrative sex was constructed as central to a masculine identity , but inability to achieve this was normalised in terms of the ageing process.
Penicillin , amoxicillin , cotrimoxazole ( trimethoprim / sulfamethoxazole ) and doxycycline should not be used as an initial antibacterial because of resistance patterns.
Penile colour Doppler ultrasonography and cavernosometry were also performed for all of the patients.
Pentosidine , an advanced glycation end product , is involved in aging phenomena such as tissue stiffness.
People ≥65 y showed reduced immune response to both regimens.
People aged 40-60 years were less likely to abstain from alcohol ( @percent@ ) than individuals aged @number@ years and above ( @percent@ ) .
People aged @number@ and older represent a fast-growing population segment who deserve specific attention and research.
People aged @number@ and over comprise @percent@ of the population of Europe.
People aged @number@ or older are the fastest growing population in high-income countries.
People aged @number@ to @number@ years with no history of TMD were enrolled at @number@ study sites when they completed questionnaires about sociodemographic characteristics.
People aging with HIV have medical and psychosocial needs that require more than the HIV services network can provide.
People aging with HIV present a unique challenge for providers.
People , along with their families , feel the impact of chronic illness in many areas of their lives.
People are generally lean during childhood and show more variability in body sizes and shapes later in life.
People are living longer and the population is ageing.
People are living longer than ever.
People are seen as active and participating subjects shaping their lives through their AC.
People from Asian cultures are more influenced by context in their visual processing than people from Western cultures.
People have shifted away from viewing food as primarily sustenance , and rather now seek out foods based on pure palatability or specific nutrition.
People in developing countries and in low socioeconomic status groups are particularly vulnerable.
People in modern , affluent societies are living longer but also becoming increasingly overweight.
People in need of care have to rely more on help from their social network.
People in quintile @number@ of DASH averaged @number@ points higher than those in quintile @number@ ( P = @number@ ) .
People may rely on many medicines to delay it.
People often encounter reminders to memories that they would prefer not to think about.
People often have to listen to someone speak in the presence of competing voices.
People older than @number@ suffer fractures at a rate of @percent@ per year @percent@ per year for persons older than @number@
People older than @number@ years were threatened by CVD mostly.
People serving prison sentences have major needs in terms of their physical and mental health.
People showed wide variations in folate forms at baseline , but these were reduced after FA treatment.
People's knowledge that they will change age groups over time likely makes relations between age groups function differently from relations between racial or gender groups.
People smile in social interactions to convey different types of nonverbal communication.
People's vision of themselves is profoundly changed as a result , as is that of those close to them.
People tend to infer general assumptions about group characteristics from exemplars.
People use different coping strategies and health locus of control to manage stressful situations , which relate to different risks of depression.
People were moderately confident overall about both their correct and incorrect responses.
People who attempt suicide make disadvantageous decisions in other contexts , but nothing is known about the way they decide about the future.
People who did not have decreased activity or their IES score was nine or lower were protective factors.
People who died had a higher CP-FI-CGA than did survivors ( @number@.48±0.13 versus @number@.38±0.15 ) .
People who do not meet at least @number@ minutes of moderate-to-vigorous physical activity are considered to be physically inactive.
People who had @number@ or more conditions among the @number@ categories of conditions were defined as having MCCs.
People who reported experiencing childhood abuse in all age groups reported more suicidal thoughts , suggesting abuse has lifelong negative effects on suicidal ideation.
People who report unmet need due to waiting times use more health services than would be expected based on their observable characteristics.
People who were at older age , with either bad eyesight or hearing , having had injury or decreased activity had higher scores.
People will be eligible if they are home-dwelling , over @number@ years of age , understand Norwegian and have functional decline.
People with ≥3 CMBs , regardless of their locations , had a higher incidence of all-cause dementia and vascular dementia.
People with a high number of stress symptoms in @number@ and @number@ were categorized as having constant stress.
People with Alzheimer's disease ( AD ) are often negatively positioned by others , resulting in difficulties upholding a positive sense of self.
People with any emotional disorder , substance abuse , known diabetes or stroke were excluded.
People with AS , but not controls , had a significant age-related reduction in NAA and the NAA / Cr ratio.
People with autistic spectrum disorders ( ASD , including Asperger syndrome ) may have developmental abnormalities in the amygdala-hippocampal complex ( AHC ) .
People with dementia are especially reactive to the environment.
People with dementia may experience both cognitive and physical complications that impact on their nutritional intake.
People with disabilities are often marginalized through their lack of access to a range of services and opportunities.
People with DISH are more likely to experience physical functional impairment , suggesting that DISH has clinical correlations and is not an incidental radiographic finding.
People with Down's syndrome ( DS ) are at high risk of developing early onset dementia.
People with Down syndrome ( DS ) have a neurodevelopmentally distinct brain and invariably developed amyloid neuropathology by age @number@
People with DS with unusual sleep postures suffered from SDB-RSs.
People with higher scores had significantly higher QALYs.
People with HIV are susceptible to bone loss , and to a condition called osteoporosis that may lead to fractures.
People with I / DD have faced a number of health disparities , including health care professionals unprepared to meet their health needs.
People with incident MCI were followed for a further @number@ years to assess progression to dementia.
People with intellectual disabilities are living longer and often experience declining mobility.
People with MCI are found to be less healthy and live unhealthy lifestyles.
People with neuropsychiatric disorders such as schizophrenia often display deficits in spatial working memory and attention.
People with normal cognition and appetite were compared with those with either poor cognition or poor appetite.
People with partial rather than complete ADL limitation appeared most vulnerable to unmet needs for home accessibility features.
People with persistent disability have social and health disadvantages compared to people with other longitudinal experiences.
People with physical limitations and disabilities are most vulnerable to unmet healthcare needs and support system from government , policy makers and family.
People with severe COPD live with increasingly troublesome breathlessness and other symptoms such as fatigue , pain , sputum production and weight loss.
People with SI reported a significantly higher proportion of restrictive activity ( @percent@ ) than those who did not have SI ( @percent@ ) .
PEP-1-FK506BP12 may have therapeutic potential in the alleviation of OA progression.
PE patients had also significantly lower cardiac output than NP , G-PIH and CH.
PE patients had a significantly higher BP than either G-PIH or NP patients.
Peptic ulcer disease ( PUD ) and gastroesophageal reflux disease ( GERD ) are not uncommon in elderly patients.
PeptideClassifier analysis was further used to map peptides to specific gene-models.
Peptide mass fingerprint analysis revealed that the C-terminal Kunitz domain is often proteolytically processed.
Peptides act as transmitters from the brain to the body , telling muscles and nerves to perform specific functions.
Peptides and proteins play an important role in skin health and well-being.
Peptides have been shown to be involved in the pathophysiology of frailty and cognitive decline.
Peptides increased vital resource and decreased the mortality rate of elderly people.
Peptides , selected by AAV peptide display , engaged novel receptors that increased cell entry efficiency by up to @number@ , 500-fold.
PEP was an eight-week training program given by a physiotherapist and nurses once a week.
PER2 : : luc bioluminescence demonstrated that circadian oscillations were significantly lower in amplitude in cartilage from aged mice.
Per capita income increases the longer the immigrants stay in the country.
Perceived age discrimination was associated with older age , higher education , lower levels of household wealth and being retired or not in employment.
Perceived anxiety control , reappraisal , and suppression did not mediate the relation between age and health anxiety.
Perceived barriers included apathy and weight loss programs being \ "too feminine. \ "
Perceived benefits of losing weight included reduced risk for health problems and looking good.
Perceived benefits were social relationships , awareness of community resources , and change in attitude toward aging.
Perceived Cognitive Impairment is an important health variable with implications for an older adult's overall health , mobility , and mental health.
Perceived control and health are often closely linked in adulthood and old age.
Perceived control is a key component of successful aging and may serve as a protective factor against age-related declines in central domains of functioning.
Perceived control moderated the positive association of network capital with binge drinking ( RR = @number@ @percent@ CI = @number@.87-0.96 ) .
Perceived control plays an important role for remaining cognitively fit across adulthood and old age.
Perceived control plays an important role in shaping development throughout adulthood and old age.
Perceived control predicts intention to start consumption of ASH in current non-consumers.
Perceived control was associated with lower mortality hazards ; however , this effect was diminished for those who experienced accelerated life satisfaction decline.
Perceived discrimination did not account for gender differences in poor physical HRQOL.
Perceived discrimination was assessed at baseline by asking participants about the frequency with which they experienced @number@ everyday discriminatory situations.
Perceived discrimination was a weaker mediator among young adults due to an absence of racial differences in perceived discrimination in that group.
Perceived facial age was determined and related to chronological age for each participant.
Perceived future support and concerns in relation to personal assistance , assistive devices and rehabilitation was also reported.
Perceived gender role is a crucial part of a person's identity and an established determinant of health.
Perceived health and level of social activity were categorical variables with three values.
Perceived health status and quality of life were also positively correlated with social engagement.
Perceived health status , ego integrity , self-achievement , self-esteem , participation of leisure activities were also influential on healthy aging as beneficial factors.
Perceived-health stress has stronger impacts under most conditions.
Perceived isolation accounted for nearly double the amount of variance in overall cognitive functioning than social disconnectedness ( @percent@ vs. @percent@ ) .
Perceived isolation was significantly related with social disconnectedness ( standardized coefficient [ r ] = @number@ ) .
Perceived or experienced life changes related to parenthood were generally positive such as personal development.
Perceived outdoor fall risks , strategies used for prevention , and outdoor fall experiences were examined.
Perceived promotion of dependence was not a significant moderator.
Perceived respect from younger generations at baseline predicted an increase in generative concern @number@ months later.
Perceived safety varied relating to home care assistants ' knowledge of medicine.
Perceived social stress partially accounts for these associations.
Perceived social support was assessed across the four dimensions of tangible , belonging , emotional and information support.
Perceived state of oral health remained difficult to interpret.
Perceived stressors , including current financial hardship or hardship experienced for an extended time period throughout the lifespan , may influence sleep later in life.
Perceived stress was measured with the 4-item Perceived Stress Scale.
Perceived work ability relative to lifetime best was categorized as excellent , moderate or poor.
Perceiving a mental health need was associated with a decreased number of physician contacts for Filipino and Korean Americans.
Perceiving and memorizing faces swiftly and correctly are important social competencies.
Perceiving children as being filial may render psychological protective effects to older adults which results in less health service use.
( @percent@ ) .
@percent@ ) .
@percent@ ) .
@percent@ affected women were multiparous.
Percentage fat was used as a covariant during statistical analyses.
Percentage of agreement and kappa values with @percent@ confidence interval ( CI ) were calculated for each evaluation.
Percentage of aneuploidy in cultures was unchanged after expansion.
Percentage of patients satisfied with the treatment results was @number@ @number@ and @percent@ in groups @number@ @number@ and @number@ respectively.
Percentage of tissue stained , cell density and size were quantified.
Percentage of whole-brain volume change ( PBVC ) and ventricular expansion over @number@ months were assessed with FSL-SIENA and ventricular enlargement ( VIENA ) respectively.
@percent@ CI : @number@.39-0.98 ) were protective against severe menopause symptoms.
Percent density reflects dense area relative to breast area and nondense area was calculated as the difference between total breast area and dense area.
Percent difference of iFR according to the increase in anatomic and hemodynamic severity was higher than that of resting Pd / Pa.
@percent@ had abnormalities on only one assessment , whereas only @percent@ had abnormalities on all three.
@percent@ had a score of 3-4 , @percent@ had a score of 5-6 , and @percent@ had a score of 7-10.
@percent@ had used an ALD in the past @number@ mo , and @percent@ owned a hearing aid.
@percent@ have at least @number@ aberrant ICA.
Percentile ranks were then calculated for age- and education-stratified groups.
@percent@ increase in the ACh-induced vasodilatation in older men compared with saline.
@percent@ in response to BQ-123 infusion ( P < 0.05 ) .
@percent@ live an independent life , @percent@ rely on parental supervision , and @percent@ depend on professional care institutions.
Percent mammographic density ( PMD ) is a strong marker of breast cancer risk.
@percent@ ( n = @number@ ) of men reported FOF , of whom @percent@ ( n = @number@ ) had fallen in the past year.
@percent@ O2 promoted the proliferation.
@percent@ of AD brains were HHV-6 positive.
@percent@ of all the enrolled cases were treated with PTAs related to hypertension , cardiovascular disease , hyperlipidemia and catastrophic Illness.
@percent@ of exitus were caused by cardiovascular disease , @percent@ by infection and @percent@ by neoplasms.
@percent@ of Germans develop prediabetes in their lifetime.
@percent@ of HIV-infected individuals were receiving ART and their median CD4 count was @number@ cells / μl.
@percent@ of hospital admissions included at least one DRP.
@percent@ of men and @percent@ of women aged over @number@ were either overweight or obese.
@percent@ of men and @percent@ of women had central obesity.
@percent@ of men and @percent@ of women were overweight.
@percent@ of participants experienced food insecurity , with @percent@ experiencing very low food security.
@percent@ of patients experienced a LTC complication and @number@ patients ( @percent@ ) died.
@percent@ of patients experienced grade ≥3 adverse events , the majority of which were unlikely therapy-related.
@percent@ of patients had been treated with calcium prior to fracture , @percent@ with vitamin D , and @percent@ of them with antiosteoporotic drugs.
@percent@ of patients noted an overall improvement in the appearance of their skin.
@percent@ of patients who were recommended new therapy initiation did not fill an antidepressant prescription.
@percent@ of physicians agreed that availability of efficacy data in the elderly influenced their decision to prescribe new therapy.
@percent@ of population was walking after @number@ months ( @percent@ with assistance ) : no difference was found between the three groups.
@percent@ of TBI subjects were classified as mild.
@percent@ of the children have at least one form of malnutrition.
@percent@ of the clients were @number@ years or older , @percent@ were living independently and @percent@ were residents in homes for elderly people.
@percent@ of the eyes operated for cataracts achieved a visual acuity ≥ 20 / 60 with available correction.
@percent@ of the participants with asthma + allergic rhinitis were polysensitized.
@percent@ of the patients attended regular school.
@percent@ of the patients had a good functional outcome ( mRS = 0-1 ) .
@percent@ of the patients had moderate or severe pain.
@percent@ of the residents were categorised as malnourished by the interviews and @percent@ by the nursing staff's assessment.
@percent@ of the subjects showed significant improvement , @percent@ moderate improvement , and @percent@ slight improvement of facial laxity in their follow-up photos.
@percent@ of the total health cost was associated with hospital admission cost , @percent@ with specialist visits cost and @percent@ with emergency visits cost.
@percent@ of the works are devoted to intergenerational relations and social status of the elderly.
@percent@ of those fully edentulous were in need of full dentures.
@percent@ of those who fell reported injury , and @percent@ reported limitations in performing activities after the fall.
@percent@ of total WBCs , p < @number@ ) , and EPC-TL ( @number@ Vs.
@percent@ of women and @percent@ of men were dependent on others for at least one daily activity.
@percent@ of women in the study group had had symptoms for more than @number@ months before tuberculosis was diagnosed.
@percent@ of women were menopausal.
@percent@ of women were not married.
@percent@ of women with tuberculosis had very extensive radiological changes covering @number@ to @number@ lung fields.
@percent@ of women with tuberculosis were bringing up children and @percent@ had abandoned their offspring.
@percent@ of workstations didn't meet the heat standards for heavy work.
@percent@ ; p < 0.01 ) in the putamen and substantia nigra pars compacta of the basal ganglia and in the pons.
@percent@ participants reported posttraumatic stress symptoms indicating current full PTSD , and @percent@ fulfilled the criteria of a current partial PTSD.
@percent@ patients experienced mild hypoglycaemia , and no severe hypoglycaemia was reported.
@percent@ patients presented pharyngeal residue.
@percent@ ( @percent@ CI @date@ @percent@ ) of clinical isolates and @percent@ of skin and soft tissue specimens contained the genes for PVL.
@percent@ ; p = @number@ ) .
@percent@ ( p < @number@ ) .
@percent@ ; p = @number@ ) and log₁₀TNF-α ( approx.
@percent@ ; p = @number@ ) , log₁₀IL-6 ( approx.
Percent predicted FVC and FEV ( @number@ ) also were assessed as continuous variables.
@percent@ received antihypertensive monotherapy , @percent@ received no hypertensive treatment , and the remainder received a combination of antihypertensive therapies.
Percent SC were significantly increased in older women at @number@ and @number@ h following RE.
@percent@ underwent ERCP or cholecystostomy.
Percent weight loss alone was not better at identifying true positives than random chance ( AUC ≤0.50 ) .
@percent@ were female.
@percent@ were female.
@percent@ were frail , and @percent@ were non-frail.
@percent@ were suffering from other chronic diseases , @percent@ could take care of themselves and @percent@ had experienced negative events during last two years.
@percent@ were women.
Perceptible ΔE between manual and mechanical mixing techniques were @number@ and @number@ for both unpigmented and pigmented specimens , respectively.
Perception of BPD as a young-person's diagnosis could lead to under recognition in older patients.
Perception of diabetes-related quality of life is associated with glycaemic control over time.
Perception of life constraints , health problems , physical activity engagement and positive affect were measured by a structured questionnaire.
Perception of neutral stimuli showed age-related decline , whereas perception of valent stimuli , both positive and negative , showed no age difference.
Perception of pain during injection was lesser with Juvéderm® probably because of the presence of lidocaine.
Perception of SAs engaged pathways involved in fear regulation and affective ToM.
Perceptions about dementia that were linked to their own existential anxiety and to a perceived similarity between people with dementia and themselves were particularly salient.
Perceptions and experiences of chronic pain in older adults have not been fully explored.
Perceptions of inconvenience , pain , and financial restrictions were important factors influencing the adoption , use , and abandonment of self-monitoring devices.
Perceptions of uncontrollable threats to health at baseline were measured using anticipated survival.
Perceptions were most positive in the geriatric-chronic care hospitals.
Perceptual assessment was also performed.
Perceptual decision-making performance depends on several cognitive and neural processes.
Perceptual functions change with age , particularly motion perception.
Perceptual-motor calibration has been described as a mapping between perception and action , which is relevant to distinguish possible from impossible opportunities for action.
Perceptual ratings and age discrimination performance were assessed in @number@ young participants.
Percutaneous absorption demonstrated high sequestering in keratinocytes with subsequent accumulation / release over time.
Percutaneous absorption of osthole , daphnoretin , coumarin , byakangelicin , and 7-hydroxycoumarin was assessed in vitro and in vivo.
Percutaneous coronary intervention ( PCI ) is a common procedure to treat coronary artery stenoses.
Percutaneous endoscopic gastrostomy is one of the applicable methods for long-term enteral nutrition support.
Percutaneous kyphoplasty was added in @number@ cases and a complementary anterior approach in @number@ cases.
Percutaneous or endoscopic therapies may decrease the risk of recurrence.
Percutaneous repair has been described to offer the benefits of open repair while avoiding the complications.
Percutaneous vertebroplasty ( PVP ) or balloon kyphoplasty ( BKP ) as minimally invasive techniques are new treatments that are widely used for painful OVCFs.
Performance accuracy and RTs for this new test depended on both visual acuity and contrast sensitivity.
Performance and reaction time during the practice of the games will also be correlated to the loneliness perception.
Performance and satisfaction with performance in everyday life are the major outcomes of reablement.
Performance at age @number@ was correlated with self-reported health for measures of processing speed and episodic memory.
Performance-based measures of the VM and VCG task were obtained during standing and walking.
Performance by e4 + was equivalent or better than e4- on all @number@ tasks , although performance benefits were less pronounced than in youth.
Performance correlated positively with central sites in young adults but with left parietal hemisphere activity in old adults.
Performance costs in older adults were primarily reflected in timeout rates.
Performance criteria were computed.
Performance data were analyzed in a repeated measures analysis of variance with time ( repeated ) and group as factors.
Performance deficits as well as a loss frequency bias were found in older adults.
Performance deteriorated under levodopa only in young subjects.
Performance did not appear to be affected by Δt.
Performance evaluation activities are more common in LHDs with a succession plan than in LHDs without a plan.
Performance gains associated with repetitive motor practice , and the associated transfer , occur within a few minutes.
Performance in episodic memory is determined both by accurate retrieval from memory and by decision processes.
Performance in many everyday situations slows down when age increases.
Performance in men with OA was more affected than in women.
Performance is also evaluated under familiarity and match / mismatch with the ethnicity of observers.
Performance is subject to change due to a variety of reasons including patient heterogeneity , learning , deteriorating skills due to aging , etc.
Performance of the ANT revealed changes in the efficiency of attention networks across ages.
Performance of the KPT markedly increased BOLD signal intensity in the PFC , and also activated sensorimotor , parietal association , and visual cortex areas.
Performance of the Luria test was graded as normal or abnormal.
Performance of thin-film solid-phase extraction ( TF-SPE ) using vials coated with ethylene vinyl acetate was compared to earthworm bioassay ( Lumbricus terrestris ) .
Performance on all Stroop tasks correlated significantly , providing evidence that they tap similar cognitive abilities.
Performance on a task such as this is thought to rely on the capacity of the individual to perform hippocampus-mediated pattern separation.
Performance on items requiring rule-based knowledge was comparable between groups.
Performance on sustained attention and the number of words generated did not show significant differences between the three genotypes.
Performance on the Information subtest had a significant effect on all same cognitive functions as educational attainment , but also on additional domains.
Performance on the MCIS is reported as the Memory Performance Index ( MPI ) .
Performance on the M-FPT was scored by computing the cumulative number of unique designs ( UDs ) performed on a 3-min administration time.
Performance on the @number@ m walk test and on TUG improved over time in all groups.
Performance on the production and comprehension measures significantly correlated with performance on the cognitive measures for the older group but not for the younger group.
Performance on the SCIT was unaffected by the confounding factors of sex , education level , and mood state.
Performance on these measures were also moderately correlated with standard measures of cognitive abilities and showed good test-retest reliability.
Performance on the spatial ability test declined with age as predicted from previous literature.
Performance on the Trail Making A & B tests was also directly related to plasma acetoacetate and CMRacac ( all p≤0.01 ) .
Performance on the UPDRS , MoCA , GDS , and NMS did not differ by mutation status.
Performances before and after the interval allowed us to calculate a forgetting rate.
Performances improved as contrast increased in HSF scenes.
Performances of DistEn were examined by theoretical data and experimental short-term RR interval series.
Performance times were lower by men than women , with the gender discrepancy higher in some older age classes.
Performance was assessed bilaterally before , during , and after this training.
Performance was assessed in terms of number of items generated , clustering , and the time course of output.
Performance was compared across young adults , older adults , and individuals diagnosed with very mild dementia.
Performance was immature in all children at the finest disparity tested.
Performance was quantified through a VT error.
Performing-arts activities promote subjective well-being only for females.
Performing PoCT seems especially worthwhile in the highest age groups.
Perfringolysin O / D4-GFP could be an important tool for investigating the effects of BrM lipid deposition in mouse models.
Perfusion decellularization is an approach that generates native ECM scaffolds with intact 3D anatomical architecture and vasculature.
Perfusion MRI was normalized using the normalization parameter of the corresponding structural MRI.
Perfusion parameters were calculated and statistically compared for both groups and subgroups.
Perfusion-related indices and self-diffusion were modelled as symmetric rank @number@ tensors.
Perfusion tended to increase in younger , but to decrease in older individuals.
Perfusion with carnosine promoted post-ischemic functional recovery in WT but not in AR-null mouse hearts.
Perhaps deterministic characteristics omitted in current deficit counts , such as reduced emotional adaptability , are more prevalent in men.
Perhaps IL-7 might be used to \ "tune \ " the immune system to optimize human healthspan and longevity.
Perhaps more importantly , research in this field has largely overlooked a highly prevalent , important , and remediable influence on the quality of communication.
Perhaps more important , the hormonal changes of the menopausal transition may be predictive of future disease risk.
Perhaps , some of these supposedly detrimental changes accompanying old age are in fact evolutionary adaptations to prolong life after reproduction in humans.
Perhaps such a paradoxical situation reflects a decreased reactivity of the immune system in the OXYS rats.
Perhaps the most notorious corollary is falling , which is often caused by an underlying gait problem.
Perhaps the practice of dual transplant should be revisited and reserved to very old and ECD-donors.
Perhaps the reason the \ "ideal \ " face-lift has yet to be discovered is a result of three factors.
Perhaps this explains the lack of positive effects of antioxidant vitamins used in extreme doses for a long time described in some publications.
Peri-and post-menopausal women's attitudes were not biomedically oriented.
Peri- and postoperative complications were recorded and described using the IUGA classification.
Periconceptual prophylactic administration of the vitamin reduces , but does not eliminate the risk of neural tube defects even in the absence of folate deficiency.
Pericyte coverage declined between small and large microaneurysms.
Pericytes are widely believed to function as mesenchymal stem cells ( MSCs ) , multipotent tissue-resident progenitors with great potential for regenerative medicine.
Perihematoma PS correlated positively with hematoma volume ( β = @number@ p = @number@ ) .
Perihematoma PS of the large-hematoma group was higher than that of the small-hematoma group ( p = @number@ ) .
Perihematoma PS was higher in larger hematomas and was associated with larger edema volume.
Periictal seizure phase durations were analyzed including tonic , clonic , total seizure , postictal EEG suppression ( PGES ) , and recovery phases.
Perimenopausal women were more likely to be classified as CST IV-A or L. gasseri CST , whereas postmenopausal women were often classified as CST IV-A.
Perimenstrual and / or postpartum mood exacerbation , or hormone therapy did not significantly alter depression during perimenopause.
Perinatal LCPUFA supplementation demonstrated beneficial effects in neural development in humans and rodents resulting in improved cognition and sensorimotor integration.
Perinatal variables and growth parameters measured between @number@ and @number@ months were assessed as predictors of an elevated SBP.
Perineometers provided reassurance , motivation , and an exercise reminder ensuring that confidence was achieved quickly.
Period analysis for 2002-2006 was used to provide the most up-to-date possible estimates of five-year relative survival.
Period analysis is increasingly used to derive up-to-date cancer survival estimates.
Period analysis methodology and regression modelling were used to obtain estimates of 5-year relative survival and tumor related excess risks in 2005-2009.
Period analysis was employed to calculate 5-year relative survival for @number@ cancers for 2002-2006.
Period analysis was used to calculate 5-year relative survival for the time period of 2002-2006 overall and by gender , age and histology.
Period analysis was used to derive 3-month , 5-year and conditional 1-year and 5-year age-standardized relative survival for 2002-2006 for each deprivation quintile in Germany.
Period analysis was used to estimate 5-year relative survival ( RS ) .
Period analysis was used to estimate relative survival for @number@ common and @number@ less common cancer sites for the period 2007-2010.
Period B was @number@ weeks in duration with dose titration identical to Period A. The dose could be reduced if necessary to reduce side effects.
Period did not modify these associations.
Period effects declined after @number@
Period effects had a more profound effect than birth cohort effects.
Period effects on network sizes occurred for personal and friendship networks , which have decreased in size over the last @number@ years.
Period effects showed a higher risk of death in the finals periods for the North and Northeast.
Periodic leg movements during sleep ( PLMS ) are the most important objective finding in restless legs syndrome ( RLS ) .
Periodic sharp-wave complexes were not observed on the electroencephalogram.
Period life expectancies are commonly used to compare populations , but these correspond to simple juxtapositions of current mortality levels.
Periodontal disease , a common chronic infection , has been previously reported to be associated with AD.
Periodontal disease is caused by dental plaque biofilms.
Periodontal disease is related to aging , smoking habits , diabetes mellitus , and systemic inflammation.
Periodontal ligament stem cells ( PDLSCs ) are promising tools for the investigations of cell differentiation and bone regeneration.
Periodontal tissues had inflammatory cell infiltration , and deep periodontal pockets.
Periodontitis is one of the most common human inflammatory diseases and has previously been associated with COPD in numerous observational studies.
Periodontitis was defined by alveolar bone loss assessed from panoramic radiographs.
Periodontitis was found in @percent@ of subjects defined by alveolar bone level ≥5 mm.
Periodontologists performed clinical periodontal examinations.
Periods of deliberate fasting with restriction of solid food intake are practiced worldwide , mostly based on traditional , cultural or religious reasons.
Periods of immobilisation are often associated with pathologies and / or ageing.
Periods of TA activity ( TAon ) and inactivity ( TAoff ) were determined using an EMG threshold based on TA resting level.
Perioperative data and outcome were assessed and compared.
Perioperative heparinization was performed in @number@ patients.
Perioperative management can be modified to minimize insults to aged tissues.
Peri-operative mortality was @percent@ for elective admission and @percent@ for emergency patients.
Perioperative mortality was zero.
Perioperative neuromuscular monitoring is therefore strongly recommended.
Perioperative stroke rate was @percent@ in both groups and mild morbidity occurred in @number@ and @percent@ , respectively ( p = @number@ ) .
Perioral lines severity improved for @percent@ and @percent@ of VYC-15L subjects at Month @number@ and Year @number@ respectively.
Perioral proportions of @number@ standardized subject photographs were measured in a photomorphometric study and correlated to age.
Periorbital lesions are dermatologic manifestations affecting the area around the eyes , excluding the eyelids.
Periorbital rhytides are often difficult to treat.
Periosteum comprises a cellular cambium layer directly apposing the outer surface of bone and an outer fibrous layer encompassed by the surrounding soft tissues.
Periostin is a marker of renal tubular injury and related to progressive kidney injury in animal models of chronic kidney disease.
Periostin knockdown in fibroblasts has no effect on collagen expression , but results in an increased fibril diameter and aberrant collagen structure.
Periostin was inversely correlated with tibia cortical thickness and density ( R @number@ @number@ both p = 0.003 ) .
Peripapillary choroidal thickness was measured between BM and AS at increasing distance away from BMO.
Peripapillary choroidal thickness was not significantly different between glaucoma and suspect patients.
Peri-papillary RNFL thickness was determined with spectral domain optical coherence tomography in four quadrants.
Peripheral and central fatigue for the knee extensors were evaluated using two isometric fatigue tests ( one voluntary and one adding electrical stimulation ) .
Peripheral arterial disease ( PAD ) becomes a significant health problem in Japan , mostly because the rapid increase of aging and diabetic population.
Peripheral arterial distensibility has been shown to be significantly lower in BRVO patients in comparison with normal subjects.
Peripheral arteries pseudoaneurysm in distal locations especially in brachial artery and forearm can cause a thrombotic complication in hands and fingers.
Peripheral blood leukocytes were obtained and the telomere restriction fragment ( TRF ) length was assayed using a digoxigenin-labeled hybridization probe in Southern blot assays.
Peripheral blood telomere length has been associated with age-related conditions including Alzheimer's disease ( AD ) .
Peripheral blood variables did not change significantly.
Peripheral edema was the most frequent AE related to PPAR-γ agonist treatment ( RR @number@ @percent@ CI @number@.37-7.23 ) .
Peripheral insulin resistance ( IR ) increases AD risk.
Peripheral intracrine sex steroid synthesis from adrenal precursors dehydroepiandrosterone ( DHEA ) and DHEA-sulfate has evolved in humans.
Peripheral LPH concentrations mediated the effect of hypertension on deep , but not periventricular , WMH volumes.
Peripheral neuropathy ( PN ) is a common neurological complication of HIV infection that has debilitating effects on quality of life.
Peripheral neuropathy symptoms at the leg and feet were assessed by self-report.
Peripheral pulse pressure ( PP ) , the difference between SBP and DBP , is an indicator for arterial stiffness.
Peripheral quantitative computed tomography was used to scan the radius at distal ( @percent@ ) and midshaft ( @percent@ ) sites.
Peripheral vascular disease and IADL impairment , but not chronological age , may be involved in the etiology of short sleep duration in older men.
Periprocedural complications occurred in @number@ ( @percent@ ) patients.
Periprocedural death occurred in two ( @percent@ ) octogenarians and five ( @percent@ ) non-octogenarians ( p = @number@ ) .
Perirenal adipose tissue volume , adipose tissue area of the renal sinus and perirenal fat thickness were manually measured bilaterally.
Perirenal fat thickness was better correlated with perirenal fat volume than adipose area of the renal sinus ( p < 0.02 ) .
Peritonitis led to failure in @percent@.
Peritubular cell N ( A ) , N ( V ) decreased significantly in aged men compared to young one , p < 0.05.
Perivascular spaces that are visible on magnetic resonance imaging ( MRI ) are a neuroimaging marker of cerebral small vessel disease.
PERK inhibition with a small molecule attenuated CHOP induction and partially rescued cells from apoptosis.
PERK is an ER membrane protein that senses unfolded protein accumulation within the ER lumen.
Permanent acrylic compounds neither presented chemoattractant properties nor showed bacterial growth over the biomaterial.
Permanent AF may contribute to Alzheimer's disease neuropathologic changes , but more study is needed.
Permanent AF was independently associated with an increased prevalence of CKD and a decreased estimated glomerular filtration rate.
Permanent and semi-permanent dermal fillers improved subjective ratings of appearance and resulted in higher patient satisfaction than temporary fillers.
Permanent down-regulation of CREB in lung cells impaired cell proliferation and viability and increased the number of cells with senescence-associated β-galactosidase activity.
Permanent HI from otitis media is substantially more likely in children and adults in Pacific Island nations.
Per-month beneficiary expenditures ranged from $ 755 to $ 1 , 778.
Permutation correction was used to adjust for multiple testing.
Permutation testing has been widely implemented in voxel-based morphometry ( VBM ) tools.
Permutation testing inference may provide a more sensitive method than traditional parametric inference for identifying age-related differences in gray matter proportion.
Permutation testing was performed to assess significant changes with age.
Peroneal motor nerve conduction amplitude and velocity were recorded.
Peroneal motor nerve conduction amplitude , distal motor latency , and mean f-wave latency were measured.
Peroxidation levels in the endometriosis group were significantly higher when compared to controls.
Peroxisome proliferator-activated receptor-gamma ( PPAR-γ ) agonists , as newly-developed oral hypoglycaemic agents , were evaluated as a possible therapy for AD.
Peroxisome proliferator-activated receptor-β / δ ( PPARβ / δ ) inhibits skin tumorigenesis through mechanisms that may be dependent on HRAS signaling.
Peroxisome proliferator-activated receptor γ ( PPARγ ) is a ligand-activated transcription factor with an important role in lipid metabolism , inflammation and cardiovascular diseases.
Peroxisomes are essential organelles in higher eukaryotes as they play a major role in numerous metabolic pathways and redox homeostasis.
Peroxisomes are found to resist oxidative stress generated elsewhere in the cell but are affected when the burden originates within the organelle.
Peroxisomes are multifunctional organelles with an important role in the generation and decomposition of reactive oxygen species ( ROS ) .
Peroxisomes are ubiquitous and multifunctional organelles that are primarily known for their role in cellular lipid metabolism.
Peroxisomes carry out many key functions related to lipid and reactive oxygen species ( ROS ) metabolism.
Per potential predictor , a logistic regression coefficient for ' having paid work in 2005-2006 ' was calculated for workers with and without chronic disease.
Persistence of inflammatory condition may be an explanation despite an improvement of inflammatory status was observed in the supplemented group.
Persistent activation of nuclear factor B ( NF-κB ) is very important in the modulation of macrophages cellular response to microbial infections.
Persistent AF is more likely to be an atrial disease.
Persistent AhR activation by dioxin , a potent agonist , results in altered numbers and function of HSCs in mice.
Persistent and diverse CE was more highly associated with better physical functioning than was persistent CE.
Persistent anemia was defined as anemia present at each measurement time point.
Persistent cell stress often enhances susceptibility to cancer and aging associated diseases.
Persistent chronic constipation occurred in @percent@ of the cohort.
Persistent disability is the dominant adverse outcome of initial disability shock.
Persistent drinkers who drank at least till @number@ were the healthiest overall.
Persistent DS was related to greater global cognition , verbal knowledge and fluency , and memory declines.
Persistent excess mortality was seen for AA and Hispanic patients with myeloma.
Persistent geriatric AKI is independently associated with a significantly higher risk of 90-day mortality.
Persistent infections with cytomegalovirus ( CMV ) differentially affect the host immune phenotype in middle-aged males and females.
Persistently elevated oxidative stress and inflammation precede or occur during the development of type @number@ or type @number@ diabetes mellitus and precipitate devastating complications.
Persistently engaged women were less likely to report anxious or depressed mood than those with early CE only.
Persistent metopic suture is associated potentially with the agenesis of the frontal sinus.
Persistent organic pollutants are a concern for species occupying high trophic levels since they can cause immunosuppression and impair reproduction.
Persistent pain and glaucoma diagnosis were independently associated with failing the visual acuity test.
Persistent pain assessment may provide an expedient method to enhance frailty measurement and improve prediction of adverse outcomes.
Persistent platelet activation plays a key role in atherothrombosis in T2DM.
Persistent serum antibodies are a proof of present or past infection.
Persistent subclinical inflammation predisposes to chronic disease , as well as the development of sarcopenia and disability , in frail elderly.
Persistent VMS were reported by @percent@ of women.
Persisting positive attitudes seemed strengthened by continued assessment experiences and perceptions of improved pain management.
Personal and clinical data were collected.
Personal and contextual socioeconomic resources of low-educated adults account for @percent@ of the variation.
Personal care hours rise with disability , but most activities decline.
Personal emergency response calls were pre-classified according to call model categories identified qualitatively from response call transcripts.
Personal familiarity is associated with the availability of semantic and episodic information as well as the emotional meaningfulness surrounding a stimulus.
Personal income and aging-related diseases were measured from the National Health Insurance database during 1997-2010.
Personality characteristics , especially neuroticism , mastery , optimism , and sense of coherence were most likely to be associated with psychosocial HRQOL.
Personality effect sizes were on par with other well-established health risk factors such as socioeconomic status , smoking , and self-reported health.
Personality explained varying proportions of variance in different domains of HRQOL.
Personality is a potentially important factor , yet evidence regarding the effects of personality on HRQOL measures is unclear.
Personality measurement in clinical and research settings might help to identify and guide interventions for older adults at risk for medication non-adherence.
Personality theory and research typically focus on chronological age as a key indicator of personality development.
Personality traits of the Yoga trainees were also investigated.
Personality traits were drawn from the @number@ Personality Factor Questionnaire and social inhibition was identified when using the inventory of interpersonal problems.
Personality was assessed by the Japanese version of NEO five factor inventory at baseline.
Personality was assessed in @number@ @number@ and @number@ ( n = @number@ @number@ and @number@ respectively ) .
Personality was assessed with the NEO-FFI.
Personality was measured using the 50-item International Personality Item Pool ( Goldberg , @number@ ) .
Personality was measured with the NEO Five Factor Inventory.
Personalized medicine involves formulating treatments based on a patient's own biology.
Personalized needs concerned interpersonal relationships , general organization of activities , leisure , housing , fitness and nutrition.
Personalized symptom profiles as described by Chinese medical terms show that most Yin deficiencies are addressed first by R6 treatment.
Personalized treatment engagement interventions designed by the authors ' group for various community settings are presented.
Personal life choices continue to differ substantially for men and women in cardiology , although differences have diminished.
Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E ( APOE ) ɛ4.
Personal support was provided by family , friends , other TKA patients , employers , and themselves.
Personal support workers ( PSWs ) are the largest occupational group in the sector.
Person-centered care interventions can effectively reduce agitation for a short term using intensive and activity-based intervention.
Person-centered care interventions were shown to reduce agitation , neuropsychiatric symptoms , and depression and to improve the quality of life.
Person-centered dementia care is widely accepted as a value-based commitment to supporting people with dementia and is a guiding principle in care services.
Person-centred modifications to the current environment including concerted efforts to know residents are meaningful in fostering quality of life.
Person-environment interactions , in this case how individuals use memory in their current cultural context , are at the core of that approach.
Persons aged @number@ to @number@ @number@ to @number@ education years , and non-White ethnicity were significantly associated with the major alcohol misuse score.
Persons aged @number@ years and older undergoing elective colorectal and cardiac operations were enrolled.
Persons at risk of sarcopenia are screened with hand grip strength and gait speed.
Persons from a non-English speaking background were excluded.
Persons leaving the study prematurely had higher baseline values and a steeper increase in their annual use of drugs.
Persons living with human immunodeficiency virus ( HIV ) harbor an increased risk of age-related conditions.
Persons ' oral health status explains substantial proportions of absolute but not of relative inequalities.
Persons surviving to older ages with HIV / AIDS often face an accelerated aging accompanied by increased comorbidity and decline in health and function.
Persons took a median of @number@ steps / day.
Persons were assigned to multimorbidity patterns if they had at least three diagnosis groups with a factor loading of @number@ on the corresponding pattern.
Persons who both executed a living will and appointed a durable power of attorney for health care preferred independent decision making.
Persons with depressieve and anxiety disorders have increased risk of developing several ageing-related somatic ilnesses.
Persons with human immunodeficiency virus ( HIV ) infection often develop complications related directly to the infection , as well as to treatment.
Persons with incident brain infarcts decline faster in cognition and have an increased risk of dementia compared with those free of infarcts.
Persons with manifest mobility limitations were excluded.
Persons with MCI may lower MS4A6A expression to minimize detrimental disease associated MS4A6A activity.
Persons with metabolic disorders are at significantly increased risk for cognitive decline and the development of vascular dementia and Alzheimer's disease.
Persons with moderate nutritional risk had @percent@ greater risk of death ( @percent@ confidence interval : @number@ @date@ ) .
Persons with moderate subclinical hypothyroidism had similar mobility and mobility decline as the euthyroid group.
Persons with more recent negative life events showed slower processing speed at baseline but no faster decline.
Persons with multiple sclerosis ( PwMS ) have high fall risk due to altered balance.
Persons with mUPD had higher total scores on the DBC-A than persons with a deletion.
Persons with PD exhibited impairments compared to healthy participants in select tasks ( i.e. , 0-back , 2-back and operation span ) .
Persons with proxy interviews , incomplete CES-D data , or cognitive impairment were excluded.
Persons with VA < @date@ and cataract were interviewed to calculate coverage and barriers for cataract surgeries.
Persons with ε2 and ε4 alleles had a larger proportion of microbleeds in the occipital lobe than persons with ε3ε3 genotype.
PERSPECTIVE : Health care system.
PERSPECTIVE : In this study of 18- to 44-year-olds , TMD developed at a higher rate than reported previously for similar age groups.
Perspectives for the management of the dysfunctional aging kidney are also addressed.
Perspectives on experienced problems , barriers , facilitators and support needs due to ageing and the Work Ability Index were gathered out as work outcomes.
Perspectives on how older adults address ageing issues are important for developing leads for nursing practice.
PERSPECTIVE : This article presents the association between insomnia severity , maladaptive sleep behaviors , and experimentally induced pain responses among people with knee osteoarthritis.
PERSPECTIVE : This article shows that bodily pain increases during the transmenopause and then diminishes during postmenopause.
PERSPECTIVE : This study found that the greatest decline in pain sensitivity with aging occurs in the lower extremities.
PERSPECTIVE : We showed that the presence of others influences the experience and expression of pain in older adults.
Pertinent past medical / surgical history as well as family history are reviewed , and the need for ophthalmology evaluation is discussed.
Pertrochanteric fractures occur when the injury is extracapsular and the blood supply to the head of femur is unaffected.
Perturbations in astrocyte mitochondrial function may accrue as the result of physiological aging processes or as a consequence of neurotoxicant exposure.
Perturbations in mitochondrial health may foster age-related losses of aerobic capacity ( VO2peak ) and skeletal muscle size.
Perturbations of rRNA biogenesis are closely related to cell senescence and tumor progression ; however , the underlying molecular mechanisms are not well understood.
Perturbations to default mode subnetworks in AD are evident in the amplitude of low-frequency oscillations in the resting brain.
Perturbed FR is associated with aging and age-related pathological conditions.
Perturbed neuronal proteostasis is a salient feature shared by both aging and protein misfolding disorders.
Perturbed TGF-β expression may play a key role in the pathogenesis of skin aging.
Pertussis immunization of pregnant women is an additional measure for optimal protection of newborns and should be promoted.
Pertussis immunization rates among close contacts of newborns need to be improved.
Pertussis is still occurring in highly vaccinated populations , affecting individuals of all ages.
PET data were acquired over a 90-min period.
PET imaging agents such as Pittsburgh compound B ( PiB ) allow detection of fibrillar β-amyloid ( Aβ ) in vivo.
PET shows metabolism of glucose and accumulation of amyloid and tau , which is useful in showing abnormal metabolism in Alzheimer's disease.
PET uses specific molecules labelled with positron-emitting radionuclides to provide valuable biochemical and physiological information.
PE was confirmed by contrast-enhanced chest computed tomography or ventilation perfusion scintigraphy in both groups.
PEX was associated with a higher IOP and cataract extraction with a lower.
PF also promotes stem cell-based regeneration as well as long-lasting metabolic effects.
PFC BDNF was linearly lower from @number@ to @number@ years of age in nonpsychiatric comparisons.
PFC volume correlated stronger with Wisconsin Card Sorting Test than with digit backwards span , Trail Making Test and verbal fluency.
PFF was assessed through muscle strength tests of upper and lower limbs , endurance , agility-dynamic balance , flexibility , and body composition.
PFGE showed high genetic variability identifying @number@ different pulsotypes , most of which single.
PFM electromyographic activity changed during the female life cycle.
PFM electromyographic activity correlated inversely with age , parity , and the presence and severity of urinary symptoms.
PFO and the exercise intensity at which this occurred ( FatMax ) were measured by a submaximal exercise test and calculated by polynomial regression.
PGC-1alpha , SIRT1 and SIRT3 protein expression was analyzed by Western blot.
PGCR , PUCR , and RPS were elicited by perfusing water into the pharynx rapidly and slowly.
PGC were noted in @percent@ versus @percent@ persons with and without stroke , respectively.
PGD2 has two known receptors , GPR44 and PTGDR.
PGE2 stimulated the proliferation of primary rat prostate stromal cells but not epithelial cells , with increased PCNA expression.
PGE ( @number@ ) treatment induces cellular senescence , as determined by a decrease in cell proliferation and an increase in senescence-associated β-galactosidase staining.
PGRN knockdown SH-SY5Y neuroblastoma cells also show enhanced Wnt5a content and signaling.
PGRN might be a particularly relevant factor in the pathogenesis of HIVencephalitis ( HIVE ) and HIV-associated neurocognitive disorders ( HAND ) .
PGRN Thr272fs mutation in the Italian population has been previously identified.
PGRN was detectable in both human and murine IVD.
Phacoemulsification ( phaco ) was done on @number@ of @number@ eyes , and @number@ of @number@ eyes had extracapsular cataract extraction ( ECCE ) .
Phadiatop results were available for @number@ participants ( men = @number@ , 839 / women = @number@ ) .
Phakinin was also truncated and was not detected in the lens nucleus.
Phalloidin-binding RPE cytoskeleton and LF-AF ( 488-nm excitation ) were imaged at up to @number@ predefined positions.
Pharm.
Pharmaceutical and cosmetics , environmental factors and lifestyle have an important effect on skin.
Pharmaceutical companies could also develop special access schemes with low prices to facilitate coverage in low-income countries.
Pharmaceutical industry developers consider both faces of the coin very relevant.
Pharmaceutical , nutraceutical , and lifestyle interventions have demonstrated some promise.
Pharmaceutical therapy is one of the approaches to prevent and treat related medical conditions.
Pharmaceutical treatment strategies are under development with some early promise and there is the possibility of clinical trials in the near future.
Pharmacies provided information on filled β-blockers.
Pharmacist can play an important role in achieving both of goals.
Pharmacist interventions in community and hospital settings were evaluated in seven studies.
Pharmacists also reported helping patients obtain financial assistance while in the Donut hole.
Pharmacists and other health care professionals play a significant role in ensuring the elderly patient receives the recommended vaccines at the recommended intervals.
Pharmacists are often asked questions about the efficacy and safety of these immunizations.
Pharmacists are requesting that practical training in home care be included in the Model Core Curriculum.
Pharmacists are the medication experts on a health care team.
Pharmacists could perform PoCT when renal function could not be retrieved from other health care professionals.
Pharmacists encountered drug-related problems amongst @number@ % of pharmaceutical-care patients.
Pharmacists have a unique opportunity to pursue accurate medication adherence in this special population.
Pharmacists have been involved in different approaches for the optimization of prescribing and rational medication use in older people.
Pharmacists performed @number@ PoCTs ( @percent@ of the alerts ) , which led to @number@ prescription modifications ( @percent@ of the PoCT ) .
Pharmacists visited the pharmaceuticalcare patients at home , once only , and followed them during the subsequent year with three telephone calls.
Pharmacists were well able to retrieve information on renal function , using PoCT in a limited number of cases.
Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd.
Pharmacogenetic and drug-interaction data may help personalize AD therapy and increase adherence by improving tolerability.
Pharmacokinetic and pharmacodynamics changes as well as polypharmacy and comorbidities may alter significantly the effect of pharmacological treatment with advancing age.
Pharmacokinetic ( PK ) and pharmacodynamic ( PD ) modeling has elucidated aspects of developmental pharmacology of value to the anesthetic community.
Pharmacokinetics boosting of protease inhibitor allows a higher genetic barrier , as few or no drug-resistant mutations are detected in patients with virologic failure.
Pharmacokinetics of anticancer drugs used in breast cancer therapy are well established.
Pharmacokinetic studies have demonstrated that the main components of Polygonum multiflorum , such as and emodin are distributed among many organs and tissues.
Pharmacologic agents are critical modifiers of leukocyte diversity in healing mechanisms that may impair or stimulate the clearance mechanism.
Pharmacological and genetic approaches were used to validate the data.
Pharmacological and genetic studies have since shown that ageing is a malleable process and that its abrogation can prevent its associated diseases.
Pharmacological blockade of melanocortin MC4 receptors prevented all neuroprotective effects of NDP-α-MSH.
Pharmacological cathepsin B inhibition using CA074Me mimicked UVA-induced accumulation of lysosomal autofluorescence and deficient cathepsin B maturation.
Pharmacological inhibition of JNK has been demonstrated to attenuate microglial activation and the release of neurotoxic chemicals including pro-inflammatory cytokines.
Pharmacological inhibition of JNK or knockdown of JNK significantly reduces the ability of MUC1 to inhibit cisplatin-induced apoptosis.
Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH ( @number@ ) metabolism towards other terminal PG synthases in monocytes.
Pharmacological inhibition of mTOR signaling using rapamycin treatment suppressed endometrial hyperplasia in aged mice.
Pharmacological inhibition of Nox4 in senescent ECs reduced LPS-induced alterations in permeability.
Pharmacological inhibition of Sirt1 blocks the suppression of Crp by nutrient restriction.
Pharmacological interventions are available but have limited effect to treat many of the syndrome's features.
Pharmacologically enhancing NMDAR function with the NMDAR co-agonist cycloserine reversed electrophysiological and behavioral deficits.
Pharmacological management is considered when nonpharmacological interventions fail.
Pharmacological manipulation of exercise benefit circuits might improve the health of the sedentary and the aging populations.
Pharmacological modulation of HO-1 induction represents a therapeutic strategy for several nervous system disorders.
Pharmacological modulation of Sirt1 and Sirt1 overexpression both affected viral transgene expression.
Pharmacological therapies for acute ischaemic stroke are limited.
Pharmacological treatment is quite similar in both older and younger patients with allergic rhinitis.
Pharmacological treatment options are similar to younger adults and avoidance of hypoglycemia is an important consideration in choosing therapeutic agents in elderly.
Pharmacological treatments aimed at improving mitochondrial function should thus have in mind the subject age.
Pharmacologic and psychotherapeutic interventions have long been studied , and in general are safe and somewhat efficacious in decreasing depressive symptoms in patients with CVD.
Pharmacologic inhibition of JAK2 kinase was achieved by JAK-Inhibitor treatment.
Pharmacologic inhibition of mutated JAK2 kinase inhibits CXCL10 expression.
Pharmacologic interventions that enhance autophagy may have chondroprotective activity in cartilage degenerative processes such as OA.
Pharmacologic studies in the last decades have shown that ginsenosides ( ginseng saponins ) are primarily responsible for the actions of ginseng.
Pharmacologic Therapy : There are various medications with antimuscarinic properties available for the treatment of OAB symptoms.
Pharmacology and pharmacokinetic data were taken from randomized trials focusing in this area.
Pharmacotherapy remains the primary treatment option for these health issues.
Pharyngeal clearance evaluated by videofluorography correlated with FEES clearance scores , as did aspiration severity with total scores statistically significantly.
Phase alignment values increased with age over the occipital , parietal and frontal cerebral regions.
Phase angle changes are described as an interaction of developmental changes in sleep regulation interacting with psychosocial factors ( e.g. , bedtime autonomy ) .
Phase angle is a composite measure of tissue resistance and reactance measured via bioelectrical impedance analysis ( BIA ) .
Phase angle ( PhA ) is an impedance parameter and it has been suggested as an indicator of cellular death.
Phase angles were the time durations from DLMO to weekday sleep onset and offset times.
Phase changes were observed on the zirconia surface with formation of the monoclinic phase in all polishing methods.
Phase-contrast MR imaging was used as the reference method.
Phase I clinical trials , employing autologous CSCs in patients with ischemic cardiomyopathy , are being completed with encouraging results.
Phase I consisted of two non-exercise groups : ( a ) placebo and ( b ) @number@ g CaHMB consumed twice daily.
Phase-locking analysis revealed a significant increase in high gamma-band ( 36-56 Hz ) synchrony indicating greater bottom-up control for feature than conjunctive search.
Phase @number@ aims ( early detection ability ) are partly achieved.
Phase @number@ comprised refinement of the content using an academic panel of experts.
Phase @number@ consisted of testing for content validity , and writing a computer-assisted instruction manual and testing it for user difficulty and satisfaction.
Phase @number@ consisted of topic and content identification using a literature review.
Phase @number@ focused on individual item analyses and subsequent revision or deletion of items , and Phase @number@ evaluated evidence for reliability and validity.
Phase @number@ mail survey ( response rate @percent@ ) took place in @number@ and phase @number@ in @number@ ( response rate @percent@ ) .
Phase @number@ studies ( quantification of impact and costs ) are still to come.
Phase @number@ studies ( quantify impact and costs ) have not been performed.
Phase @number@ studies ( routine use in prodromal patients ) are ongoing , and only preliminary results can be extrapolated from retrospective observations.
Phase was negative in the range of @number@.78-4.3 Hz and fluctuated at high frequencies.
PhA was calculated directly with its arctangent ( resistance / reactance×180° / π ) .
PhDs most frequently noted depression in residents.
PhDs received @percent@ of all awards , with average funding per award of $ 457 , 413 compared to $ 505 , 516 for MDs.
PhDs reported least satisfaction with treatment.
Phenolic antioxidants provide active system of defence against lipid peroxidation , however , the effectiveness of their antioxidant action depends on several important parameters.
Phenolic compounds are of crucial importance for red wine color and mouthfeel attributes.
PHENOMENA OF INTEREST : Women with UI from various social and cultural settings were included in this review.
Phenomenological analysis was used with the qualitative data.
Phenomenological interviews and conversations with an open approach were conducted and analysed with a focus on meanings.
Phenomenon of the senescence induction in human endometrium-derived mesenchymal stem cells ( MESCs ) in response to SMS factors has not yet been described.
Phenotypes are defined as dimensions of behavior , closely related to fundamental mechanisms , and , thus , may be more informative than chronological age.
Phenotypic analysis in conjunction with genetic data revealed that the Iranian patients were also affected with HMSN-P.
Phenotypic plasticity in vascular smooth muscle cells ( VSMC ) is necessary for vessel maintenance , repair and adaptation to vascular changes associated with aging.
Phenotyping included αβ-T-cells , γδ-T-cells , B-cells and myeloid cells.
Phenprocoumon , acenocoumarol and fluindione were rated FORTA-C ( questionable ) , mainly reflecting the absence of data.
Phenylalanine concentration , vitamin D , PTH , and nutrient intake do not correlate with BMD or BTM.
Philadelphia Corporation for Aging ( PCA ) established Age-Friendly Philadelphia ( AFP ) to catalyze efforts to improve the physical and social environments for seniors.
Phlorizin is well known to inhibit sodium / glucose cotransporters in the kidney and intestine for the treatment of diabetes , obesity and stress hyperglycaemia.
PHLPP1α expression changes dramatically in the hippocampus during development , constituting the most abundant PHLPP protein in adult neurons.
PHLPP2-deficient primary hepatocytes or CRISPR / Cas9-mediated PHLPP2-knockout hepatoma cells were analyzed for insulin signaling and gene expression.
Phonation with high intensity highlights differences between groups , especially in perceptual parameters.
Phonological access and reaction time measures were significantly and positively correlated , and semantic access and reaction time were significantly and negatively correlated.
Phonological capacities were assessed using a lexical decision task and nonword repetition.
Phonological capacities were equivalent across age groups , so we were unable to account for differences across age groups in verbal working memory.
Phonological sensitivity predicted sentence recognition for implant users but not for listeners with normal hearing.
Phorbol 12-myristate 13-acetate-activated human neutrophils produced superoxide radical of @number@ ± @number@ nmol / min / 10 ( @number@ ) cells.
Phorbol ester ( PMA or TPA ) , a tumor promoter , can cause either proliferation or cell cycle arrest , depending on cellular context.
Phosphatase and tensin homologue ( PTEN ) protein levels are critical for tumor suppression.
Phosphate restriction has been shown to improve clinical outcomes in patients with chronic kidney disease ( CKD ) .
Phosphate was uncommon in man ( @percent@ ) , but frequent in woman ( @percent@ ) with a type IVa1 organization.
Phosphatidylserine exposing erythrocytes are further engulfed by phagocytosing cells and are thus rapidly cleared from circulating blood.
Phosphatidylserine exposure was identified using annexin-V binding.
Phosphodiesterase inhibitors ( PDE-Is ) are pharmacological compounds enhancing cAMP and / or cGMP signaling.
Phosphodiesterase ( PDE ) III is an enzyme in vascular smooth muscle that metabolizes cyclic adenosine monophosphate ( cAMP ) .
Phosphoenolpyruvate carboxykinase ( PEPCK ) expression plays a critical role in the modulation of gluconeogenesis.
Phospholipids derived from milk proteins represent one potential candidate treatment.
Phospholipids show affinity for polyphenolics , and form supramolecular adducts having a definite stoichiometry.
Phospho-protein signatures provide mechanistic clues to signaling networks implicated in these effects.
Phosphoproteomics has recently gained attention as a valuable approach to analyze protein phosphorylation , both in a quantitative and a qualitative way.
Phosphorus burden may lead to poor outcomes.
Phosphorylated p38 MAPK and phosphorylated JNK accumulated in the ante-auricular dermis and epidermis , respectively.
Phosphorylated Tau found to be reduced in TauXDrp1 + / − mice relative to Tau mice.
Phosphorylation , acetylaton , and cellular redox state also regulate most signal transduction pathways and activities of multiple transcription factors.
Phosphorylation at C6-position of O-mannose catalyzed by protein O-mannosyl kinase ( POMK ) is a crucial step in the biosynthetic pathway of O-mannose glycan.
Phosphorylation of Akt , mechanistic target of rapamycin , and 70S6K was determined with specific antibodies.
Phosphorylation of desmin is also implicated in many forms of desmin-related myopathies ( desminopathies ) .
Phosphorylation of FoxOs by Akt inhibits transcriptional functions of FoxOs and contributes to cell survival , growth and proliferation.
Phosphorylation of Smad2 and Smad3 increased after @number@ h of glycitin treatment , and phosphorylation continued for @number@ h.
Phosphorylation of TPP-1 was carried out and phosphorylated TPP-1 was named as PTTP-1.
Phosphorylation regulates tau-microtubule interactions and hyperphosphorylation contributes to the aberrant formation of insoluble tau aggregates in Alzheimer's disease ( AD ) and related tauopathies.
Photic stimulation dilates retinal arterioles producing blood flow increases , a response termed functional hyperemia.
Photo-aged and prematurely photo-aged skin showed greater hTERT expression than young and aged skin.
Photoaged skin is characterized by epidermal changes and damaged elastic fiber and collagen fiber networks.
Photoaging differs from what one sees in Western populations due to the inherently dark skin of Indians.
Photoaging , in particular , generates reactive oxygen species ( ROS ) that stimulate mitogen-activated protein kinase ( MAPK ) signaling and transcription factors.
Photo-aging is a consequence of exposure to ultraviolet radiations.
Photoaging is a cumulative process which depends on the degree of UV exposure and the skin type.
Photoaging is directly correlated to the quantity of UV rays received during the course of a lifetime.
Photoaging is frequently encountered in a dermatologic practice.
Photoaging of skin occurs partially due to decreased synthesis and increased degradation of dermal collagen.
Photobleaching was monitored by photography and transmission measurements.
Photodamage assessed 96h post UVA included HSE morphology , keratinocyte proliferation , apoptosis , and differentiation.
Photo-damaged skin is characterized by major alterations of the extracellular matrix and collagen network , leading to clinically obvious signs of skin aging.
Photodamaged skin is characterized by progressive damage to the dermal extracellular matrix with loss of collagen and degradation of elastin.
Photodamage in the treatment area was ' much improved ' with imiquimod @percent@.
Photodynamic therapy and local chemotherapy are properly positioned to bridge the gap between surgery and chemoradiotherapy.
Photodynamic therapy is promising approach for treatment ofphotoinduced skin aging and takes place between ablative and non-ablative methods for skin rejuvenation.
Photodynamic therapy with lasers and intense pulsed light is addressed , with particular reference to actinic keratosis and actinic cheilitis.
Photograph analyses were performed by @number@ blinded evaluators.
Photographic analysis demonstrated improvement in skin variables at all body sites treated.
Photographic analysis using a computer program was conducted on oblique facial views preoperatively and postoperatively , to obtain the most projected malar contour point.
Photographic stimuli were then presented to @number@ naive observers in a blinded paired comparison.
Photographs and assessments were repeated at days @number@ and @number@
Photographs both in static and in frown state were taken and classified based on the method of @number@ glabellar line patterns.
Photographs of each patient from prior to treatment , and @number@ months after treatment were analyzed by @number@ blinded physician raters.
Photographs of models with attractive gazes were examined , and old photographs of patients were compared to recent photographs.
Photographs of @number@ male individuals were evaluated using @number@ anthropometric indices.
Photographs of the face in a relaxed pose were taken at baseline , optimal correction visit , and @number@ weeks after optimal correction.
Photographs were judged by @number@ independent members of the public who were asked to rate apparent age.
Photographs were taken at baseline and at @number@ and @number@ weeks after the injections.
Photographs were taken at baseline and at numerous time points for up to @number@ years.
Photographs were taken at rest and during motion ( frontal and oblique views ) , before and after treatment.
Photographs were used to score glabellar frown lines.
Photo-protection is an effective method for preventing skin damage and its consequences.
Photoprotection is the primary preventive and therapeutic strategy against photoaging and skin cancer.
Photoreceptor outer segments with stacks of membranous discs containing the phototransduction machinery are continuously renewed in the retina.
Photoreceptors in the older DJ-1 KO mice displayed decreased immunoreactivity to rhodopsin and localized reduction in cone markers compared to the wild-type control group.
Photos were to be taken in rural settings of their choice , thus fostering both urban and rural student exposure to diverse rural communities.
Phototherapy and systemic agents were not given to patients with scalp psoriasis alone.
Phototoxic reactions such as erythema and edema were the primary side effects , as well as an increase in postinflammatory hyperpigmentation.
Photovoice emerged as a powerful teaching method to increase awareness , empathy and compassion of young adults towards ageing.
Photovoice is also recommended for use in rural courses other than nursing.
PHP and ( PPHP ) are rare disorders resulting from genetic and epigenetic aberrations within or upstream of the GNAS locus.
PH rapidly induced marked increases in circulating E2 and ERα transcripts in periportal hepatocytes , well before the onset of hepatocyte proliferation.
PHVs are also more often provided to patients listed with a GP who has an overall high tendency to conduct these visits.
Phylogenetic analysis of BKPyV isolates was performed.
Phylogenetic tree analysis yielded @number@ haplogroups.
Phylogeny-based statistical analysis reconstructed ancestral states.
Phylum Verrucomicrobia showed statistically significant ( p = @number@ ) differences in abundances between the GE-fed and control-fed groups.
Physical abuse was among the least encountered , with psychological abuse and financial exploitation being the most common types of maltreatment reported.
Physical activities had a significant association with cognition only among women.
Physical activities increased in those with higher education for both males and females ( P < @number@ ) and showed significant differences on occupations.
Physical activity ( accelerometry ) , time in sedentary activity , birth factors , and parental weight were compared.
Physical activity and cohabiting appeared to be beneficial.
Physical activity and DCI were assessed using questionnaires.
Physical activity and peak aerobic fitness were not related to the MetS in this group with a long-standing SCI.
Physical activity and successful aging health education interventions were compared after 12-months of follow-up.
Physical activity assists older individuals ' functional ability and postural stability.
Physical activity can improve and maintain function , strength , and balance , which are important for those receiving home care.
Physical activity can improve blood flow in the body but little is known about the relationship between physical activity and cerebral perfusion in older adults.
Physical activity deficits were even greater in the men who reported that they were fearful of falling than in men who had fallen.
Physical activity dose was assessed by 7-day accelerometry and self-report at baseline and @number@ months.
Physical activity has been linked to positive health outcomes for frail seniors.
Physical activity has been proposed as one of the most effective strategies to prevent cognitive decline.
Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models.
Physical activity has positive benefits for healthy aging.
Physical activity influences all age related cardiovascular mechanisms , improves cardiovascular function and even , at moderate intensity can reduce mortality and heart attack risk.
Physical activity in later years of life is not only essential to healthy aging and independent functioning , but it also helps prevent chronic diseases.
Physical activity is a multifactorial behavior with various factors playing a role in determining individual physical activity levels.
Physical activity is a promising intervention for preventing and managing Alzheimer's disease.
Physical activity is associated with cardiovascular risk reduction , but the effects of exercise on platelet activation remain controversial.
Physical activity is associated with well-being and happiness.
Physical activity is considered to be one of the few ways to influence the level of frailty.
Physical activity is important for older people because it assists in living independently.
Physical activity is known to have beneficial effects on a host of factors related to physical and mental health , and positively affects postural control.
Physical activity is known to increase mitochondrial content in skeletal muscle , counteracting age-related decline in muscle function and protecting against metabolic and cardiovascular complications.
Physical activity is predictive of better cognitive performance and lower risk of Alzheimer's disease ( AD ) .
Physical activity is very effective in reducing sclerostin , which is known to inhibit bone formation.
Physical activity level appears to partly explain some of these associations.
Physical activity levels were categorized as sedentary , low , or high.
Physical activity level was determined through questions about frequency and duration of physical activities.
Physical activity may play an important role in maximizing bone mass during adolescence to young adulthood and may have long-lasting benefits on bone health.
Physical activity may potentially be involved in this relationship.
Physical activity may promote cognitive health in older adults.
Physical activity , moderate exercise , and dietary behavior decreased with educational level , while screen time increased.
Physical activity moderates such insidious aging patterns and is a vital preventive and therapeutic strategy to optimize health throughout the aging process.
Physical activity must be encouraged by policies to foster health promotion.
Physical activity ( PA ) and cardiorespiratory fitness ( CRF ) are associated with successful brain and cognitive aging.
Physical activity ( PA ) and vitamin D are thought to affect colorectal cancer prognosis.
Physical activity ( PA ) can influence the ageing process but the specific relationship with healthy ageing ( HA ) is unclear.
Physical activity ( PA ) has been identified as beneficial for many diseases and health disorders , including sarcopenia.
Physical activity ( PA ) may modify the genetic effects that give rise to increased risk of obesity.
Physical activity ( PA ) significantly reduces all-cause mortality and contributes to the prevention of many chronic illnesses.
Physical activity plays an important role in preventing chronic disease in adults and the elderly.
Physical activity recommendations were presented in @percent@ of articles ; a wide range was recommended ( 90-300 min of physical activity per wk ) .
Physical activity six months after T1 partially mediated this relationship.
Physical activity , smoking , use of alcohol , chronic diseases and depressive symptoms were self-reported by standard questionnaires.
Physical activity was also a significant mediator between physical problems and positive affect.
Physical activity was also classified on the basis of the number of steps.
Physical activity was assessed both by metabolic equivalent ( MET ) in a respiratory chamber and by an accelerometer.
Physical activity was assessed using an Actigraph ( GT3X + ) activity monitor ; physical activity by type was reported with the CHAMPS activity questionnaire.
Physical activity was assessed via a semiquantitative questionnaire at baseline and at @number@ follow-up visits ( approximately @number@ and @number@ years later ) .
Physical activity was assessed with a questionnaire consisting of @number@ components ( leisure-time , work , and sport activities ) .
Physical activity was assessed with pedometers and accelerometers.
Physical activity was estimated by actigraphy.
Physical activity was found to have a significant path coefficient towards the measure of positive attitude and emotion.
Physical activity was higher in Maori than non-Maori ( p = 0.035 ) and the relationship was attenuated when adjusted for age.
Physical activity was measured according to kilocalorie expenditure.
Physical activity was measured using a validated questionnaire.
Physical activity was measured using Stayhealthy RT3 accelerometers over @number@ days.
Physical activity was measured via the Baecke questionnaire.
Physical activity was measured with accelerometry.
Physical activity was monitored by a wearable activity monitor to quantify volume and intensity of overall physical activity and selected habitual activities over @number@ hours.
Physical activity was monitored on seven consecutive days of the week , using a triaxial accelerometer ActiGraph GT3X.
Physical activity was negatively associated with recurrent falls.
Physical activity was positively associated with fitness performance , while pain and depression symptoms were negatively associated.
Physical activity was reassessed six months later ( T2 ) and self-rated health after @number@ years ( T3 ) .
Physical activity , wisdom , better ability to cope with life and contacting young generation were effective in the positive attitudes of both groups.
Physical ageing and being old are broadly feared or denied , particularly by the young ( Chittister 2008 : @number@ ) .
Physical aging abolishes membranous COL17 in IFE basal cells because of inactive atypical protein kinase C signaling and also induces epidermal hyperproliferation.
Physical and biological changes in bodily function with age can also affect oral health care either directly or indirectly.
Physical and cognitive capacity , depressive and anxiety symptoms were measured by validated scales and aphasia / dysarthria by a single question.
Physical and cognitive function , level of physical activity and wellbeing were assessed by means of reliable and valid instruments.
Physical and cognitive limitations , multiple comorbid conditions , and polypharmacy are some aspects that can influence the choice of treatment in this age group.
Physical and cognitive limitations often accompany aging , increasing the importance of a safe and supportive environment to help older adults maintain mobility.
Physical and emotional decline in older adults is a serious issue affecting not only quality of life but also susceptibility to injury.
Physical and emotional strains were similar in both groups of caregivers.
Physical and mental component scores of a quality of life measure were captured by telephone interview at @number@ and @number@ months after recruitment.
Physical and mental deprivation may complicate proper assessment of pruritus severity and negatively impair compliance with complex antipruritic therapies.
Physical and mental functioning was reported most frequently ( @percent@ and @percent@ ) .
Physical and physiologic changes with aging , preexisting diseases , and treatments result in increased morbidity and mortality for this population.
Physical and psychological functioning is linked , but the temporal nature of this association remains unclear.
Physical capacity was measured by a validated scale ( @number@ low-12 high ) .
Physical component summary was inversely related to the GDS-15.
Physical conditions were based on self-reported diagnoses by health professionals.
Physical disability and cognitive impairment are routinely registered for long-term care users through a standardised instrument that is used in all Norwegian municipalities.
Physical disability is one of the main age-related diseases which affect life quality.
Physical diseases and risk factors were also investigated.
Physical examination , clinical histories and medication profile were obtained from each patient.
Physical examination usually yields few significant data but it can help for detecting unidentified cases of early onset TD.
Physical exercise and dietary protein have been emphasized in prevention and treatment of sarcopenia.
Physical exercise and fitness have been proposed as potential factors that promote healthy cognitive aging.
Physical exercise and fitness have been proposed as potential factors that promote healthy cognitive aging.
Physical exercise diminishes inflammation and elevates agents and factors involved in immunomodulatory function.
Physical exercise , especially those involving aerobic or resistance training , seems to have marked beneficial effects on P300 in the elderly.
Physical exercise harnesses implicit and inherent biologic characteristics amenable to the putative interventional influences under clinical , institutional or laboratory conditions.
Physical exercise induces several metabolic adaptations to meet increased energy requirements.
Physical exercise intervention studies generally found significant and large improvements in physical capacity , in some cognitive domains , and in quality of life.
Physical exercise , in the frail elderly , should be prescribed with a progressive individualized plan and just like other medical treatments.
Physical exercise is advised as a preventive and therapeutic strategy against aging-induced bone weakness.
Physical exercise is a powerful stimulus to PGC-1α expression and signaling.
Physical exercise is known to have beneficial effects on muscle trophism and force production.
Physical exercise may reduce or retard age-related brain deterioration by a mechanism involving neuro-glial processes.
Physical exercise moderated the relationship between genotype and dementia ( p < @number@ ) .
Physical exercise regimes have induced manifest anti-inflammatory benefits , mediated possibly by brain-derived neurotrophic factor.
Physical fitness assessments were performed at all time points.
Physical fitness ( PF ) was evaluated by a set of @number@ tests and a fitness index ( FI ) was calculated.
Physical fitness was analyzed objectively using the EXERNET test battery.
Physical fitness was assessed using the chair rise , the 6-min-walking and the handgrip strength test.
Physical fitness was evaluated by a set of eight tests.
Physical fitness was measured as the total work performed in a maximal exercise tolerance bicycle test.
Physical frailty and cognitive frailty are two important targets of secondary intervention in aging research to narrow the gap between life and health span.
Physical frailty ( PF ) and sarcopenia are major health issues in geriatric populations , given their high prevalence and association with several adverse outcomes.
Physical frailty was defined on the basis of slow gait speed , and depression was assessed using the Center for Epidemiologic Studies Depression Scale.
Physical functioning and gait speed were measured with the Short Physical Performance Battery ( SPPB ) .
Physical functioning was compared in sarcopenic and non-sarcopenic older adults.
Physical function measures included static and dynamic balance , chair rise , stair climb , gait speed , and 6-min walk test.
Physical function testing consisted of tasks designed to mimic common physical activities of daily living ( ADL ) .
Physical function was assessed using gait velocity.
Physical function was assessed using the Senior Fitness Test.
Physical function was assessed using the Short Physical Performance Battery ( SPPB ) at baseline.
Physical function was declined in aging as well as sensory function in human.
Physical function was measured : 6-min walk distance , Short Physical performance battery , handgrip strength and quadriceps strength.
Physical function was measured by observed physical performance testing , including chair stand , tandem stand , and timed walk.
Physical function was measured using the chair stand test as well as the usual and fast gait speed tests.
Physical health and agentive orientation at baseline can impede or accelerate decline in the sense of control.
Physical health concerns were highly prevalent in both groups.
Physical health factors were found to play a major role for well-being decline , but in interaction with psychosocial characteristics such as social participation.
Physical health issues were the main causes but also loss of confidence and transport issues.
Physical health problems become more common as people age and are associated with a great deal of disability.
Physical health status at baseline did not predict new onset of MDD.
Physical health-sum score showed a stronger negative association in 1992-2001.
Physical health was assessed through self-report ( subjective ) and physical diagnoses ( objective ) .
Physical illness emerged as an increasingly important factor and increased its influence from @percent@ to @percent@ of the total effect.
Physical illness may precipitate psychological distress among older adults.
Physical inactivity , aging or pathological disorders increase the sensitivity to oxidative stress by altering the bell-shaped dose response curve.
Physical inactivity in HF may contribute to cognitive impairment and exacerbate risk for conditions such as Alzheimer's disease.
Physical inactivity is a modifiable risk factor for the development of noncommunicable diseases.
Physical inactivity is prevalent in HF and correlated with reduced cardiac and cognitive function.
Physical inactivity negatively impacts on erectile function ; experimental and clinical exercise interventions have been shown to improve sexual responses and overall cardiovascular health.
Physical inactivity per se is not more deleterious in FDR subjects as compared with CON subjects with respect to derangements in AT metabolism.
Physical inactivity that accompanies ageing and disease may hasten disability by reducing skeletal muscle contractility.
Physical inactivity was defined as not meeting the current UK physical activity guidelines for older adults.
Physical independence was assessed with a 12-item composite physical function scale.
Physical limitations and difficulty in understanding the instructions and concepts made completing it a challenge.
Physically active leisure plays a key role in successful aging.
Physically active women had fewer severe physical symptoms related to menopause than inactive women.
Physically fit patients without significant co-morbidity are likely to benefit from the standard treatment of fludarabine , cyclophosphamide and rituximab ( FCR ) .
Physically more active persons may gain more benefit from cognitive stimulation than the physically less active.
Physical , nutritional and mental hormetins , which initiate stress responses and strengthen the homeodynamics , are potentially effective aging modulators.
Physical or mental resources were not correlated with lower levels of loneliness.
Physical performance and oral health were correlated ( p < 0.001 ) .
Physical performance , cognitive function , psychological function , and a dual-task test were assessed at baseline.
Physical performance improved preferentially in the 100M-group ; immunologic improvement occurred in both the 100M- and 200M-groups.
Physical performance is evaluated through the 5-repetition chair stand test.
Physical performance measurement may be an important research and clinical tool to predict adverse outcomes among aging HIV-infected persons.
Physical performance measures demonstrated significant different group means among the disability subgroups based on both categorization models.
Physical performance measures included maximum grip strength and habitual walking speed.
Physical performance measures such as walking speed and standing balance are highly predictive of subsequent disability and mortality in older adults.
Physical performance outcome measures were walking speed , balance time , chair rise time and grip strength.
Physical performance testing consisted of four validated assessments : the @number@.4-meter walk , 30-second chair stand , grip strength and 6-minute walk test.
Physical performance test scores were analyzed using the ROC curves to discriminate frailty statuses.
Physical performance was also assessed using the short physical performance battery ( SPPB ) .
Physical performance was assessed by grip strength , gait speed and chair stands.
Physical performance was assessed using the Lower Limb Summary Performance Score.
Physical performance was assessed using the Short Physical Performance Battery.
Physical performance was assessed with the Senior Fitness Test ( SFT ) and PA with a multisensory activity monitor SenseWear Pro @number@ Armband.
Physical performance was assessed with the Short Physical Performance Battery and self-reported mobility disability was evaluated at the 3- , 6- and 9-year follow-up.
Physical performance was measured by jumping height and grip strength.
Physical performance was measured by the Short Physical Performance Battery ( SPPB ) .
Physical performance was measured through several validated tests.
Physical performance was measured using performance-oriented mobility assessment ( POMA ) scores and isokinetic muscle strength.
Physical performance was measured using the short physical performance battery , usual gait speed , and grip strength.
Physical performance was tested with walk , chair stand and balance tests.
Physical problems were also common in this population with an average self-report of @number@ problems per prisoner.
Physical rehabilitation benefited the functional outcomes of this group of cancer survivors regardless of age.
Physical rehabilitation is beneficial in older people , but relatively little is known about effects in residents of long-term care facilities.
Physical rehabilitation is the basic method for all programs of medical rehabilitation on different pathologies.
Physical risk factors and psychological factors were associated with frailty within each group.
Physical signs of old age may be obvious , but mental and cognitive changes require more careful observation.
Physical stiffening of the large arteries is the central paradigm of vascular aging.
Physical symptoms , but not worry symptoms , distinguished older adults with clinical and sub-threshold GAD.
Physical therapy affects bone mechanical strength by stimulating bone cells.
Physical work demands were assessed as demanding body postures.
Physician and subject assessments both indicated that clinical improvements in all photodamage parameters were apparent at one month and persisted at least three months.
Physician-assisted death is now legal in California , and similar laws are being considered in many other states.
Physician-evaluated skin tone and patient ratings of skin texture and overall improvement of the SST-treated side were consistently higher than the contralateral NAFL-treated side.
Physician needs to be familiar with these requirements before using the machine.
Physician PCPs who derived less than @percent@ of their Medicare billings from NH residents cared for @percent@ of all NH residents.
PHYSICIAN QUALIFICATION : Any qualified dermatologist may administer fractional laser treatment.
Physician respondents comprised @number@ generalists and @number@ specialists from @number@ European countries France , Germany , Italy , Spain , and the United Kingdom.
Physicians and clergy were important across all three classes.
Physicians ' and district nurses ' professional knowledge was a safety guarantee for the medicine process.
Physicians and older asthmatics probably either do not perceive or accept a poor asthma control.
Physicians and patients rated the cosmetic effects highly , and both groups reported a preference for Voluma in those patients previously treated with Restylane.
Physicians are well situated to promote advance planning to Canadians.
Physicians completed patient record forms , and data were analyzed for clinical outcomes and their relationship with the choice of appropriate therapy.
Physicians frequently miss it on radiographs due to lack of knowledge and overexposure of spinous processes in most X rays.
Physicians have to learn how to use these drugs optimally in specific settings.
Physicians may earn @number@ AMA PRA Category @number@ Credit by successfully completing the examination based on material covered in this article.
Physicians must be active and counsel patients and partners to improve adherence to penile rehabilitation or erectile dysfunction treatment.
Physicians need at least a rudimentary knowledge of the array of options and the implications of each.
Physicians need to have knowledge of how to implement continuous quality improvement and culture change.
Physicians or pharmacists rarely inform patients about this adverse effect and its potentially severe damage to the teeth , mouth and general health.
Physicians recommended the development of an easily searchable , online database containing available CSSs.
Physicians relied on home-care case managers to help make linkages to CSSs.
Physicians reported that pharmaceutical company representatives are the most common ( @percent@ ) source of information about market entry of a generic medication.
Physicians should always assess the use of herbal medications with patients and discuss the possible benefits and side effects with them.
Physicians should be alert to the possibility of symptoms of hypogonadism in this population.
Physicians should be aware of early intervention and treatment options should impending necrosis become apparent.
Physicians should be aware of the various presentations and treatment options for these reactions.
Physicians should be aware of this high-risk condition when prescribing new drugs to disabled older people.
Physicians should be informants , advocates , and facilitators of this big leap for their patients.
Physicians should be sensitive to the range of psychosocial distress and social disruption common to dying patients and their families.
Physicians should check with their patients to confirm understanding and address concerns , as older women may not always voice their reservations and concerns.
Physicians should consider LD pharmacokinetics when treating elderly PD patients.
Physicians should consider that worsening of symptoms might result from newly diagnosed diabetes mellitus while treating patients with HNPP.
Physicians should consider the early initiation of second-line therapy in certain cases of anti-NMDAR encephalitis.
Physicians should only claim credit commensurate with the extent of their participation in the activity.
Physicians should therefore avoid prescribing PIM for older adults whenever feasible.
Physicians should understand the complicated anatomy surrounding the eyes , both to understand the aging process and to minimize treatment complications.
Physicians treating patients with COPD need to become aware of these extrapulmonary aspects.
Physicians use ultrasound scans to obtain real-time images of internal organs , because such scans are safe and inexpensive.
Physicians varied widely in their knowledge of dementia care and willingness to consider cessation of screening.
Physicians were also allowed to document any other reasons that influenced their decision.
Physicians were asked to record data of three eligible rivastigmine naïve ( or on rivastigmine for < @number@ year ) AD patients.
Physicians were asked to review the diagnosis , diagnostic confidence , and treatment after the scan.
Physicians were grouped into quintiles according to individual effects estimated in a preliminary model.
Physicians were most often contacted if changes were new , unusually severe , persisted or worsened , or failed to respond to lay treatment.
Physicians were the largest professional group ( @percent@ ) .
Physicians will face more young adult patients , which presents an opportunity for more prevention-oriented care.
Physicochemical characterization , in vitro stability studies , in vivo water content of the stratum corneum and transepidermal water loss studies were carried out afterwards.
Physiol.
Physiologic aging is likely more important than chronologic aging.
Physiological aging affects early sensory-perceptual processes.
Physiological aging of the brain has to be clearly distinguished from pathological alterations of the brain for reliable and early diagnoses of neurodegenerative diseases.
Physiological aging of the kidney is responsible for the development of functional impairments in the elderly.
Physiological and transcriptomic changes were analyzed before and after training.
Physiological BVL / year rates were remarkably consistent between the two cohorts and independent from the scanner applied.
Physiological changes in transparent dentin that involve deposition of mineral casts in the dentinal tubules lead to lower attenuation of OCT signal.
Physiological concentrations of insulin also reversed high glucose-induced increases in p53 and vascular cell adhesion molecule-1 and decreases in senescence marker protein-30.
Physiological concentrations of insulin preserved telomere length and delayed endothelial senescence under high-glucose conditions.
Physiological conditions , including normal ageing and hibernation , may exhibit tau phosphorylation and some aspects of tauopathies.
Physiological connectivity developed between the ipsilateral cerebral hemisphere and the paralyzed hand.
Physiological dysregulation may underlie aging and many chronic diseases , but is challenging to quantify because of the complexity of the underlying systems.
Physiological effects of aging make the older population more susceptible to adverse drug events and drug-drug interactions.
Physiological indexes were collected continuously during the entire procedure using a 2-channel near infrared spectroscopy ( NIRS ) and an ECG monitoring system.
Physiologically , Notch signal transduction plays a pivotal role in differentiation ; pathologically , Notch signaling contributes to the development of cancer.
Physiologically , testosterone appears to have both positive and negative effects on the cardiovascular system.
Physiological studies demonstrated that converted α cells acquire hallmark β cell electrophysiology and show glucose-stimulated insulin secretion.
Physiologic and immunologic changes that occur in COPD often mimic changes seen in the aging lung.
Physiologic processes become less resilient ; the potential for harm from medical care increases.
Physiotherapy-led treadmill training can easily be transferred into the German healthcare context since the environmental and educational preconditions are met by German physiotherapeutic care.
Physostigmine given as post-treatment resulted in a time-dependent reduction of the protection from soman inhibition and recovery of AChE.
Phytochemical investigations revealed that the major bioactive substances of Achyranthes plants are polysaccharides , polypeptides , triterpenoid saponins , and ketosteroids.
Phytochemicals are structurally diverse secondary metabolites synthesized by plants and also by non-pathogenic endophytic microorganisms living within plants.
Phytochemicals present in fruits , vegetables , grains , and other foodstuffs have been linked to reducing the risk of major oxidative stress-induced diseases.
Phytochemicals , which are non-nutritive chemicals found in plants and food , have emerged as modulators of key cellular signaling pathways exerting proven anticancer effects.
Phytoestrogens as weak estrogens , antioxidants , and anti-inflammatory agents may counteract this process.
Phytoestrogen treatment interventions have also shown time-limited positive effects on cognition.
Phytomedicine has been successfully used in dermatology horizon for thousands of years.
Phytonutrients are the plant nutrients with specific biological activities that support human health.
Phytonutrients play a positive role by maintaining and modulating immune function to prevent specific diseases.
Phytosterol esters ( PSE ) are esters of phytosterol.
Phytosterols , a class of naturally occurring structural components in plant foods , have been demonstrated to possess cholesterol-lowering and antioxidant effects.
PI3K / Akt inhibitor LY294002 reversed Q3GA-induced Akt phosphorylation and cyclin D1 expression , thereby reducing Q3GA-induced proliferation.
PI3K-blocking strategies , specifically inhibition of PI3Kγ or PI3Kδ , restored neutrophil migratory accuracy , whereas SHIP1 inhibition worsened migratory flaws.
PiB + individuals with more severe SCD demonstrated the steepest cognitive decline.
PiB PET images were corrected for partial volume effects and coregistered to FLAIR images and WM masks.
PiB retention increased in the anterior cingulate gyrus , precuneus cortex , parietal cortex , and anterior ventral striatum.
Piceatannol delayed the age-related decline of pumping rate and locomotive activity , and protected the worms from heat and oxidative stress.
PICH binding also appears to diminish force-induced DNA melting.
Pick bodies in PiD are immunopositive for 3R-tau.
Picky children seemed to develop a lower protein intake despite similar total energy intake and diet composition.
Pictorial illustrations enhanced explicit memory for target country names.
Picture-naming performance for @number@ black-and-white drawings was investigated in @number@ Hebrew speakers , ages 5-86.
PI does not improve the prediction of IHD over age and systolic blood pressure.
PIE can interrogate complex plasma samples with the percentage of peptides identified successively increasing with even ≥4 iterations.
Piecewise exponential models were used to estimate relative rates ( RRs ) and @percent@ confidence intervals ( CIs ) for these outcomes.
Piecewise latent growth modeling was used to examine trajectory of performance on outcome measures.
Piecewise linear regression models were used to survey pre-defined ages associated with menopause and andropause in relation to arterial stiffness.
Piecewise models centered at the year of retirement were applied.
PIE involves the re-injection of samples with exclusion of the previously identified peptides.
PIE methods may therefore expand our ability to recover plasma peptides for plasma biomarker discovery.
PIF showed excellent reliability and acceptability and is therefore recommended for assessing inspiratory muscle strength in older people without known obstructive lung disease.
PIGD was present in @percent@ and FoF in @percent@ of the participants.
Pig laryngeal cartilages are similar to their human counterparts in shape and size , also undergo mineralization , facilitating the study of cartilage mineralization.
Pigmentary disorders are the prime example of cultural factors affecting dermatoses and their treatment.
Pigmentation genes have been hypothesized to contribute to this association.
Pigmented microglia were distributed diffusely throughout the cerebral white matter and expressed CSF1R poorly.
PI has been reduced in verbal tasks and performance increased by presenting distinctive items across trials.
Pilot participants were compared with two control groups processed according to standard California DMV license renewal procedures.
Pilot results indicate that possible physical benefits accrue from retirement living , although efforts to reduce sedentary time are needed.
Pilot work suggests that the presence or absence of these effects may also predict responsiveness to treatment using CBT.
PIM1 expression was higher in TN tumors than in RP tumors and was associated with poor prognosis in patients with hormone- and HER2-negative tumors.
PIMs listed regardless of co-morbidities in all seven criteria sets were long-acting benzodiazepines and tricyclic antidepressants.
PIMs regardless of co-morbidities were most similar among the Beers , Rancourt and Winit-Watjana criteria.
PIMT is a repair enzyme that initiates the conversion of l-isoAsp ( or d-Asp ) residues to l-Asp residues.
PIM use was common ( up to @percent@ according to Beers criteria ) .
PIM use was defined according to Finnish criteria.
Pin1 acts on proteins after they have been phosphorylated at specific sites , causing them to twist between two completely distinct conformations.
Pin1 also regulates the cell cycle and is a necessary enzyme for cell division.
Pin1 biology opens exciting preventive and therapeutic horizons for both cancer and neurodegeneration.
Pin1 catalyzes the flip between two distinct orientations , called cis and trans , around the proline bond.
Pin1 deficiency in mice leads to an early-aging phenotype , suggesting that Pin1 activity is necessary for healthy aging and the prevention of age-related diseases.
Pin1 has also been implicated as being neuroprotective in aging-related neurodegenerative disorders including Alzheimer's disease where Pin1 activity is diminished.
Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase that plays a critical role in mediating protein conformational changes involved in signaling processes related to cell cycle control.
Pin1 is oxidatively modified in human AD brains , but little is known about its regulatory mechanisms and pathological significance of such Pin1 modification.
PINK1 has been shown to protect against neuronal cell death induced by oxidative stress.
PINK1 is a mitochondrial kinase that is involved in mitrochondrial quality control and promotes cell survival.
Pinpointing where healthy brain aging leaves off and dementia begins is difficult.
PINP peaks during second-third Tanner stage of breast development in girls and at third Tanner stage of genital development in boys.
Pioglitazone may offer a novel strategy for the treatment of AD.
Pioglitazone may thus prove to be a novel therapy for coronary spasm.
Piracetam is able to restore this impairment and shifts mitochondrial morphology back to elongated forms , whereas there is no effect in control cells.
PIs induced senescence markers , prelamin A accumulation , oxidative stress , and inflammation in HCAECs.
PIs may also have a role in premature aging in HIV / AIDS as they cause prelamin A accumulation.
Pistachio antioxidants preserved overall skin thickness and organization , as well as fibroblast morphology , in HSE exposed to UVA irradiation.
Pittsburgh Sleep Quality Index ( PSQI ) measured overall sleep pattern and quality.
Pituitary tumors are one of the major clinical components of syndromes associated with the p27 pathogenic mutations MENX and MEN4.
Pivotal clinical studies in therapeutic indications demonstrate noneriority and comparable safety of NT @number@ to another available BTX-A preparation.
Pivotal Phase III trials were utilized for discussion of clinical trial experience and to summarize efficacy and AEs.
Pivotal to this sensory role is the release of ATP from the urothelium.
PI was common in the cohort ( @percent@ ) .
PI was objectively evaluated using the standing center of pressure sway area.
Pixel-based measures of pharyngeal wall thickness and pharyngeal lumen area were completed using ImageJ and then converted to metric units.
Pixel intensity summaries were obtained to compute muscle-to-fat indices and relative muscle CSA , that is , CSA void of fat.
Pixel-wise spatial congruence was also high ( SI = .97 ) .
PIXI calcaneus T-values < -1.6 ( osteoporosis , adjusted ) were found in @percent@ of women and in @percent@ of men.
PIXI calcaneus T-values ≤-2.5 ( osteoporosis ) were found in @percent@ of women and in @percent@ of men.
PK activity was significantly increased in the frontal and temporal cortex in AD.
PKA regulators span multiple processes , including the antagonistic autophagy and methionine biosynthesis pathways.
PK digestion has also been used to detect differences in prion strains.
PK has also been used as a tool to probe the structure of PrP ( Sc ) .
PKP2 mutations may be a molecular substrate leading to the diagnosis of BrS.
PLA2G4A protein expression was examined by Western Blot , and PGE2 , LH , FSH , and E2 serum levels were detected by ELISA.
PLACE AND DURATION OF STUDY : Department of Histopathology , Armed Forces Institute of Pathology , Rawalpindi , from @date@ to @date@ .
Placenta also showed evidence of shorter TL after adjustment for relevant covariates.
Placental membrane proteins were isolated from women of different ages after first and third trimesters of pregnancy.
Place was the Emergency room in a general community hospital in Oslo , Norway.
Plain radiographs and a CT scan showed a posterior hip dislocation.
Plain radiographs were obtained on all patients preoperatively , postoperatively , and at most recent follow-up.
Planar models of muscle-driven locomotion , accounting for @number@ muscles grouped into @number@ equivalent actuators , were developed.
Plan conformality indicators were calculated.
Planned interventions to improve service utilization should ameliorate ambivalence about accessing health care in addition to addressing traditional systems or environmental-level barriers.
Planning and implementing of physical activity is so important for older happiness.
Planning based only on age leads to overestimation of the population level of health care need if successive cohorts are becoming healthier.
Planning defined as the predetermination of a sequence of actions towards some goal is crucial for complex problem solving.
Planning for future health care often involves anticipating health-related quality of life ( HRQoL ) in states of reduced cognitive functioning.
Planning for their care requires an understanding of the impact of cancer and chronic conditions on quality of life.
Planning pregnancy is preferable after female patients achive and maintain low disease activity or remission of RA.
Planning remained a significant predictor of unimanual performance in the older age group , but not bimanual or sequencing performance.
Planning was the primary predictor of performance on all three Purdue subtests.
Plantar centre of pressure ( COP ) variables during gait have been used to predict risk of injury , or consequences thereof.
Plantarflexion strength ( p = @number@ ) and soleus fascicle length ( p = @number@ ) were independently associated with TUG.
Plantarflexion strength was a stronger predictor of mobility than leg extension strength or power.
Plantar flexor rapid torque was also higher in Young ( @percent@ ; P < @number@ ) .
Plantarflexor stiffness was strongly related to general balance performance , particularly in quiet stance ; but this effect did not depend on age.
Plantar pressure and knee and trunk kinematics were measured ; performance data were recorded from the machine.
Plant-derived dietary polyphenols may improve some disease states and promote health.
Plants and their parts possess several chemical components that play the vital role in the improvement of human health and their life expectancy.
Plants contain many health benefit properties like antioxidant , anti-aging , neuroprotective , anti-genotoxic , anti-mutagenic and bioinsecticidal activity.
Plants from @number@ families were reviewed.
Plants growing in the Judea region are widely used in traditional medicine.
Plants / plant-derived components have been used from ancient times to treat / cure several human diseases.
Plaque composition also plays an important role in directing remodeling.
Plaques are composed of the amyloid-β peptide derived from cleavage of the amyloid precursor protein ( APP ) .
Plaque-size distributions changed across the lifespan in a line- and region-dependent manner.
Plaques , tangles , and minicolumns were quantified , postmortem , for @number@ controls , @number@ MCI , and @number@ AD subjects.
Plaques were obtained from @number@ type @number@ diabetic and @number@ nondiabetic patients undergoing carotid endarterectomy.
Plaque type distribution differed significantly by clinical course.
Plaque type distribution was analyzed in relation to clinical data.
Plaque types were classified according to demyelinating activity based on stringent criteria.
Plaque with extensive calcification is more likely to undergo constrictive remodeling.
Plasma acetoacetate concentration and the blood-to-brain acetoacetate influx rate constant were also increased by 2-3-fold ( all p≤0.03 ) .
Plasma adiponectin and leptin levels were measured as possible confounding parameters.
Plasma adiponectin , GLP-1 and betatrophin levels were measured by ELISA.
Plasma adiponectin was significantly higher in MCI and AD compared to NC , whereas CSF adiponectin was significantly higher in MCI compared to NC.
Plasma and mitochondrial membrane potentials , cell excitability , intracellular Ca2 + levels and bioenergetics were measured in cultured cerebral cortical neurons exposed to diazoxide.
Plasma and SkM HSP70 were unrelated and HSP70 release from peripheral blood mononuclear cells was positively associated with insulin concentrations in contrast to SkM.
Plasma and sputum KL-6 levels correlated inversely with obstruction and positively with smoking history and ageing.
Plasma apoB-100 concentration was higher , whereas the rate of oxidation of the ingested lipid was lower ( P < @number@ ) in the elderly.
Plasma ApoE did not predict clinical progression.
Plasma Apo-E levels show a mild correlation with CSF Apo-E levels , but were not associated with longitudinal cognitive and MRI changes.
Plasma Aβ42 was lower than values for demented or non-demented adults with DS.
Plasma aβ concentrations may have dynamic biological determinants across the lifespan ; plasma aβ study designs or analyses must consider age.
Plasma Aβ levels alone did not dissociate DS adults with and without dementia.
Plasma Aβ measurement and magnetic resonance imaging were performed at baseline and after a 4-year follow up.
Plasma Aβ measurement and MRI examination were performed at baseline and after a 4-year follow-up.
Plasma BCAAs and leucine turnover ( relative to FFM ) were higher in OW-Untrained vs Control , but did not change on average with exercise.
Plasma betatrophin levels were significantly increased in lean patients with PCOS compared with lean and obese controls.
Plasma biomarkers were assessed by multiplexing using Milliplex Human Cardiovascular Disease panels.
Plasma CCK concentrations , appetite responses and energy intake at a buffet meal were determined.
Plasma ceramide concentrations were measured on a liquid chromatography tandem mass spectrometry metabolomics platform.
Plasma cholinesterase activity correlated positively with calcium and haemoglobin and negatively with total bilirubin and international normalised ratio.
Plasma concentration of IL-6 , IL-8 and IL-10 were measured before surgery and at postoperative day ( POD ) @number@ and POD @number@
Plasma concentrations of armodafinil and its metabolites were quantified over @number@ hours following the last dose on day @number@
Plasma concentrations of Aβ40 , Aβ42 were measured using a sandwich enzyme-linked immunosorbent assay technology.
Plasma concentrations of miR-126 were negatively correlated with age and logBNP.
Plasma concentrations of oxycodone and its noroxycodone , oxymorphone and noroxymorphone metabolites were measured for @number@ hours with a liquid chromatography-tandem mass spectrometric method.
Plasma cortisol was measured in the morning and determined by high performance liquid chromatography-mass spectroscopy , along with other blood analytical parameters.
Plasma CTproET-1 concentrations were quantified using a novel immunoluminometric sandwich assay.
Plasma cyclic GMP , ICAM-3 , and thrombomodulin concentrations differed between young and old participants ( P < @number@ ) .
Plasma cysteine and homocysteine were measured by an ion-pair HPLC method.
Plasma cytokine levels were measured over 48h after oral application of 5g resveratrol.
Plasma dehydroepiandrosterone ( DHEA ) decreases ~80% between ages @number@ and @number@ yr.
Plasma DHA was measured in blood samples obtained at that visit.
Plasma DKK-1 levels are reduced with improvement of glycemic control and low-dose aspirin treatment.
Plasma DKK-1 levels were markedly higher in patients with T2DM than in healthy patients ( P < 0.0001 ) .
Plasma dp-cMGP was not associated with the risk of CVD.
Plasma ( dp ) ucMGP was associated with presence of knee OA features but not progression.
Plasma enrichments and metabolite concentrations were measured by GC- and LC-MS / MS and statistics were performed by student t-test.
Plasma free fatty acid , insulin , and homeostatic model assessment insulin resistance ( HOMA-IR ) levels were also significantly increased in the doenjang group.
Plasma Hcy levels were measured by high-performance liquid chromatography at baseline and after @number@ weeks of treatment.
Plasma insulin and branched-chain amino acid concentrations increased to a greater extent after ingestion of whey compared with casein.
Plasma insulinemia and EAA / aemia were markedly greater after WP than LEAA ( P < @number@ ) .
Plasma irbesartan concentrations were measured by high-performance liquid
Plasma klotho concentration can be reliably measured in stable COPD ; however , its levels are not correlated with clinical parameters of patients.
Plasma klotho concentration was assessed by enzyme-linked immunosorbent assay.
Plasma LECT2 levels differed based on the presence of metabolic syndrome and dyslipidemia , but not hypertension and insulin resistance.
Plasma level of 25-hydoxyvitamin D ( 25-OHD ) was also measured.
Plasma levels and activities of antioxidants were also measured.
Plasma levels of B-type natriuretic peptide ( BNP ) increase in proportion to the severity of left ventricular ( LV ) dysfunction.
Plasma levels of IGF-1 ( ng / ml ) and IL-6 ( pg / ml ) were measured by ELISA.
Plasma levels of miR-20a-3p , miR-30b-5p , miR106b , miR191 and miR-301a were confirmed to show significant age-related decreases ( all p≤0.004 ) .
Plasma levels of sTNFR1 were higher for non-sarcopenics elderlies.
Plasma levels of transferrin , fibrinogen , haptoglobin , and interleukin-6 were determined with enzyme-linked immunosorbent assay.
Plasma levels of von Willebrand factor and factor VIII , bleeding symptoms , treatment requirements and comorbidities are possibly changing with age.
Plasma matrix metalloproteinase-1 , TIMP-1 , amino-terminal propeptide of type I and type III procollagen and renin angiotensin system activity were measured.
Plasma membranes are selected by illumination with an evanescent electromagnetic field and distinguished from intracellular membranes assessed by whole-cell illumination.
Plasma methoxytyramine is a novel biomarker of metastatic pheochromocytomas and paragangliomas.
Plasma omega-3 fatty acids were measured at baseline ( @number@ ) and approximately @number@ years later using gas chromatography.
Plasma phospholipid fatty acids were assessed by using gas chromatography.
Plasma phospholipid n-3 FAs were measured by using gas chromatography , and incident diabetes was ascertained by using information on hypoglycemic agents and serum glucose.
Plasma PK parameters were calculated using noncompartmental methods.
Plasma Q10 is an important factor in cardiovascular diseases.
Plasma redox-state-based pharmacologic interventions to control or improve E ( h ) CySS may be effective in preventing CVD onset or progression.
Plasma samples from all subjects are analyzed using direct ELISA.
Plasma samples from infant observational cohorts reveal a relative plasma ADA deficiency at birth , followed by a gradual maturation of plasma ADA through infancy.
Plasma samples were phenotyped for paraoxonase status , and frequencies were @number@ @number@ and @number@ for QQ , QR , and RR phenotypes , respectively.
Plasma S-nitrosothiols were unchanged ( @number@.79±4.81 nM to @number@.27±5.79 nM , p = 0.3 ) .
Plasma SP-D and MMP-9 levels did not change with age but were elevated in OS and COPD as compared to ONS.
Plasma testosterone ( T ) , dihydrotestosterone , estrone , 17-estradiol ( E2 ) , and sex hormone-binding globulin were measured.
Plasma TFPI levels in children did not demonstrate an UFH concentration -dependent reduction , as has been previously reported in adults.
Plasmatic levels of homocysteine were also determined in the same individuals.
Plasma total homocysteine was quantified using a fluorescence polarization immunoassay.
Plasma ucMGP did not reflect CAC in healthy older adults.
Plasma viscosity and blood viscosity have been measured with a cone-plate viscometer.
Plasma visfatin / NAMPT concentrations positively correlate with inflammation and insulin resistance , and are decreased in the oldest.
Plasma vWF level in vWF gene A1381T polymorphism with AA mutant is significantly lower than that with AG and GG mutant.
Plasmids encoding blaNDM-1 have been observed to be spreading among gram-negative bacteria around the world.
Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments.
Plasticity in this network may explain some of the sensorimotor and cognitive enhancements that have been associated with music training.
Plasticity of inhibition in older adults : Retest practice and transfer effects.
Plastoquinone , a very effective electron carrier and antioxidant of chloroplasts , was conjugated with decyltriphenylphosphonium to obtain a cation easily penetrating through membranes.
Platelet activation increases with age , although it is still controversial whether it derives from aging per se or from atherosclerosis concomitant with aging.
Platelet concentrates enjoyed some clinical popularity in facial plastic surgery several years ago.
Platelet count and fibrinogen levels correlated significantly with clot strength , and fibrinogen levels correlated with fibrin polymerization.
Platelet counts and D-dimer concentrations were measured to assess any changes to coagulation function.
Platelet damage in the pediatric cases is higher than in adult flow , highlighting thrombus complication dangers of pediatric BMHV flows.
Platelet NOx2 may be a novel target for platelet activation inhibition.
Platelet-rich plasma ( PRP ) , a high concentration of platelets in a small volume of plasma , is known to enhance tissue healing.
Platelets are best known as primary mediators of hemostasis and can be either targets of ROS / RNS or generate radicals during cell activation.
Platelets are crucial mediators of the acute complications of atherosclerosis causing life-threatening ischemic events throughout plaque development.
Platelets have a dynamic functional repertoire that mediates hemostatic and inflammatory responses.
Platelet transfusions are used in clinical practice to prevent and treat haemorrhage in thrombocytopenic patients or patients with severe platelet dysfunction.
Platelet TXNIP content was greater ( 376±33 units ) in the aging compared to younger subjects ( 289±13 units ; p < 0.05 ) .
Platforms such as proteomics and metabolomics ( not described here in detail ) also offer simultaneous readouts of hundreds of proteins and metabolites.
Platysmal bands at rest and with maximal tension reached a statistically significant improvement.
Plausible mechanisms include homocysteine neurotoxicity , vasotoxicity , and impaired methylation reactions vital to central nervous system function.
Plausible mechanisms link these changes to cognitive and behavioural features of adolescence.
Players born in the month of November had the greatest longevities whereas those born in June had the shortest life spans.
PLD produces phosphatidic acid ( PA ) , a bioactive lipid involved in multiple aspects of cell physiology , including signaling and membrane trafficking processes.
Please see later in the article for the Editors ' Summary.
Please see later in the article for the Editors ' Summary.
Please see later in the article for the Editors ' Summary.
Pleiotropic actions displayed by melatonin prevent several processes involved in neurodegeneration such as neuroinflammation , oxidative stress , excitotoxicity and / or apoptosis.
Pleiotropic genes and genetic variants have been identified by genome-wide association studies ( GWAS ) linking NCD entities hitherto thought to be distant in etiology.
PLF was also increased in SII associated with a shortened peak latency of SEFs. wPLI analysis revealed the increased coherent activity between SI and SII.
PlGF and its receptors thus offer new targets for anti-FLS therapy.
PlGF gene overexpression resulted in the opposite effects.
PL has also been shown to accelerate removal of UV-induced photoproducts , highlighting its anti-carcinogenic role.
Plin2 expression resulted higher in old age for both HD and LLMI patients , while Plin5 slightly decreased only in LLMI patients.
PLIN4 is a member of the PAT family of lipid storage droplet ( LSD ) proteins.
PL is a natural product that is reported to have many pharmacological effects , including anti-tumor activity.
PLK1 and MTORC1 reside together at lysosomes , the subcellular site where MTORC1 is active.
PLK1 inhibition enhances MTORC1 activity under nutrient sufficiency and in starved cells , and PLK1 directly phosphorylates the MTORC1 component RPTOR / RAPTOR in vitro.
PLK1-MTORC1 binding is enhanced by amino acid starvation , a condition known to increase autophagy.
Plk3 also has a tumor-suppressing activity as aging PLK3-null mice develop tumors in multiple organs.
PLK3 ( - / - ) murine embryonic fibroblasts contained an enhanced level of HIF-1α under hypoxic conditions.
PLO declined markedly after the 70-year-old participants reached the age of @number@ and @number@ years ( p < .001 ) .
Plots were drawn to show sleep depth and awakenings across the night.
Plotting of fat-free mass evolution against age at baseline showed an exponential loss of fat-free mass.
PLS analysis was applied to identify overtime relationships between measures.
PLS-SEM explained @percent@ of the variance of BMI at age @number@ with BMI at age @number@ being the most important predictor.
Pluripotent stem cells ( PSCs ) offer unprecedented opportunities for disease modeling and personalized medicine.
Plus addresses PA and weight loss management strategies.
PLWH are likely , therefore , to have increased healthcare needs for the foreseeable future.
PM2.5 effects and mechanisms are understudied among nondiabetic individuals.
PM2.5 was negatively correlated with ICAM-1 methylation ( p = @number@ ) , but not with other genes.
PMAb83 reduced tumor growth and distant metastasis in orthotopically xenografted mice of human PDAC cells.
PMAb83 treatment retarded proliferation along with weakened aggressiveness traits of the carcinoma cells.
PMA transiently activated mTOR , enabling partial geroconversion.
Pmax-rel declined gradually with age , reaching @percent@ of the peak in subjects in their 70s.
PMD dropped by @percent@ ( @number@.4-3.4 ) on menopausal transition and increased by @percent@ ( @number@.4-3.5 ) with the use of hormone therapy.
PMI was defined as hs-cTnT after coronary intervention higher than 99th percentile upper reference limit ( URL ) .
PMK-1 and members of the insulin signaling pathway , PDK-1 and AKT- @date@ , were also identified as mtl-1 regulators.
PNA ( peptide nucleic acid ) probes for telomeres together with a chromosome two centromere probe were used.
Pneumatization of the sphenoidal sinus was evaluated.
Pneumococcal disease has substantial incidence , morbidity and mortality in older adults.
Pneumococcal vaccines are recommended for people > 65 years old.
Pneumonia cases can vary in both severity and chest X-ray findings.
Pneumonia generates considerable negative impacts on the elderly.
Pneumonia in the long-term resident is common.
Pneumonia , malignant tumors , asphyxia , and multiple-organ failure are the common causes of death.
Pneumonia or other causes of respiratory failure were the most common causes of admission to ICU ( @number@ % ) .
Pneumonia was the cause of death with the highest frequency.
PNF was assessed via standard surface electroneurographic study of right peroneal nerve conduction velocity , vibration and touch sensitivity.
PNIF , blood eosinophil counts and VAS of nasal symptoms were higher in patients with AR.
PNIF measurements were performed in @number@ volunteers aged 65-84 years.
PNN50 improved in @percent@ patients of the MT group , but in none of the control group ( p = 0.013 ) .
PNP was found clinically and electrodiagnostically in @percent@ of patients.
( P ≤ @number@ ) .
( P = @number@ ) and @time@ .
( P < @number@ OR = @number@ ) .
P < @number@ was considered statistically significant.
( P = @number@ ) with a maximum mean difference of @number@ pmol / l ( @percent@ ) .
PN ( wm ) area increased with higher memory loads ( 3- and 2-back > 0-back tasks ) in younger subjects.
POCD and cognitive decline were assessed using the reliable change index utilizing the results of the control group.
POCD is recognized as an important neuropsychological adverse outcome in surgical patients , particularly the elderly.
POCD is transient disturbance that can affect patients of any age but is more common in elderly people.
POCD was diagnosed if a decline of > 1 standard deviation of z-scores was present in ≥2 variables of the test battery.
Pocket Size Imaging Device ( PSID ) has a potential value as a screening tool , because of its possible use in several clinical settings.
Podocyte injury and loss owing to genetic , toxic , immunologic , or metabolic insults underlie the most common glomerular diseases.
Podocyte loss was only seen in old G4 Terc ( - / - ) .
Podocytes are terminally differentiated cells of the kidney filtration barrier.
Podocyturia may be considered a marker of active glomerular disease.
Poetry-based Stimulation also improved complex linguistic abilities.
POI and age of menopause have a significant hereditary component.
POI has been shown to have long-term consequences on overall health.
Point-process linear models of stride intervals have been recently proven to provide a unique characterization of human gait dynamics through instantaneous time domain features.
Points of subjective simultaneity were also not correlated with speech intelligibility scores.
Poisson and negative binomial regressions were used to estimate three count dependent variables : physical symptom , chronic , and life-threatening medical conditions.
Poisson regression analysis was used to estimate the excess relative risk ( ERR ) of cancer incidence related to in utero and postnatal doses.
Poisson regression as well as multilevel age-period-cohort models with adjustment for obesity and smoking were incorporated.
Poisson regression models were built to analyze the association between baseline kidney function and cognitive decline.
Poisson regression models were used to assess these longitudinal relationships.
Poisson regression was used to calculate crude and adjusted rate ratios ( RRs ) examining the association between field impairment and at-fault collision involvement.
Poisson regression with generalized estimating equations was used to assess predictors of ED and Kaplan-Meier curves time to ED.
Poisson regression with robust variance estimator was employed to determine the association between childhood subjective socioeconomic status , height , and functional limitations.
Polarization-enhanced multispectral wide-field imaging device allows for in vivo real time visualization of dermal structures.
Polarization optical imaging has the potential for rapid noninvasive in vivo evaluation of human dermis.
POLD3 is the human ortholog of POL32 in budding yeast , and has been shown to act during break-induced recombinational repair.
Policies and programs are needed to retain the current and attract new village doctors into the workforce.
Policies are required that offer more resources to community-dwelling people with disabilities in China.
Policies promoting smoking reduction and healthy diet should thus target older men and women , respectively.
Policies should also deal with gender idiosyncrasy in certain cases.
Policies that reduce exposure to SHS at home have great potential for reducing healthcare and mortality costs.
Policies to promote older people's participation in nonformal educational activities are discussed in light of the data.
Policy ambitions to put people at the center of their own care are being developed internationally.
Policy guidance that restricts treatments to defined patient sub-groups can improve the cost-effectiveness of treatments , and can help limit rises in health care expenditures.
Policy implications for assisted living settings and meeting the growing demand for a competent direct care workforce are discussed.
Policy implications for regulating bodies , employers , unions and educators are discussed.
Policy initiatives , including geriatric health education , partnerships with community and grass-roots leaders will promote awareness.
Policy is called for to mitigate the difficulties of this vulnerable population.
Policymakers and clinicians should be mindful of the variation in diagnosis rates among subgroups of the population with dementia.
Policymakers can promote practices to lower direct service worker turnover such as addressing burnout and increasing support.
Policymakers have to learn from innovations outside the system in order to change it.
Policymakers must be equally proactive in expanding LTC capacity , lest unsustainable acute care utilization and significant deficits in the number of healthcare professionals arise.
Policy makers need to address the impact the reforms are having on older Cubans and consider them as active participants in economic reform.
Policymakers should consider welfare effects associated with coverage restrictions.
Policy makers worldwide need to address these health inequalities , and support the complex service needs of a growing multimorbid population.
Policy reacted by implementing financial incentives for GPs in rural areas and special GP training programs.
Polishing of zirconia is possible , but glazing is not recommended for the surface finish of zirconia.
Political management to prevent sexually transmitted infections needs to be continued in elderly people as it is in other age groups.
Pollution may be a risk factor for melasma and other facial pigmentary dyschromias.
POLN is very weakly expressed in most tissues , with the highest relative expression in testis.
Polo-like kinase @number@ ( Plk3 ) plays an important role in the regulation of cell cycle progression and stress responses.
POL reduction for @number@ U persisted until week @number@ ( p < @number@ ) .
POL severity and total lip satisfaction ( TLS ) were assessed at all visits.
Poly ( ADP-ribose ) polymerase-1 ( PARP-1 ) is a NAD-consuming enzyme with an emerging key role in epigenetic regulation of gene transcription.
Poly-ADP-ribose polymerase ( PARP ) genes displayed the most sites under positive selection.
Poly ( ADP-ribose ) polymerase ( PARP ) was dispensable for NHEJ suggesting that repair is largely independent of backup NHEJ.
Poly ( ADP-ribose ) polymerases ( PARPs ) are a diverse group of proteins present in all multicellular eukaryotes.
Poly ( ADP-ribosyl ) ation plays a key role in a plethora of processes including DNA repair , tumor progression and aging.
Poly ( ADP-ribosyl ) polymerases ( PARPs ) have traditionally been linked to chromosome maintenance and DNA repair.
Polyamide denture base material had a similar toxicity profile with conventional heat- and cold-cured PMMA.
Polyaromatic hydrocarbons are associated with extrinsic skin aging , pigmentation , cancers and acneiform eruptions.
Polychemotherapy is still preferred in fit older women.
Polycomb group protein BMI1 is an important regulator of senescence , aging , and cancer.
Polycystic ovary morphology was most accurate at predicting the PCOS diagnosis for women ages 30-39 years.
Polycystic ovary syndrome ( PCOS ) is a common metabolic and reproductive disorder in women.
Polyester fabrics were implanted into rats to fabricate hybrid tissue-fabric material sheets.
Polyfunctionality was higher in the elderly adults.
Polyglutamine diseases , including Machado-Joseph disease and Huntington's disease , typically appear in midlife and are characterized by amyloid accumulations of abnormally expanded polyglutamine proteins.
Polygonum multiflorum is a traditional Korean medicine that has been utilized widely in East Asian countries as a longevity agent.
Poly-l-lysine ( PLL ) , a homopolymer of amino acid l-lysine ( LL ) , has been frequently used for drug delivery.
Polymerase chain reaction analysis revealed that all subjects did not carry the most common R47H TREM2 variant.
Polymerase chain reaction-based genotyping of the highly polymorphic merozoite surface protein @number@ gene was performed on blood samples collected at @number@ cross-sectional surveys.
Polymerase chain reaction ( PCR ) amplification of extracted DNA followed by restriction enzyme digestion was used to genotype the samples.
Polymers , peptides , liposomes and nanoparticles developed as gene carriers have achieved efficient cellular uptake of genes.
Polymorphisms in GEMIN4 and DGCR8 could modify these associations.
Polymorphisms in microRNA-related genes could influence response to PM.
Polymorphisms of DNA repair enzymes may affect repair efficiency and thereby lead to the development of age related cataract.
Polymorphisms of DNA repair enzymes may affect repair efficiency and the role of DNA repair mechanisms has received attention recently in age-related cataract pathogenesis.
Polynomial regression was used to model the influence of age on gray matter volume and fractional anisotropy at a whole-brain and voxel level.
Polypeptides from the detergent-insoluble , urea-soluble protein fractions of amygdala were interrogated using liquid ionization-tandem mass spectrometry.
Polypharmacy ( 5-9 drugs ) was reported in @percent@ of the population , and excessive polypharmacy ( @number@ drugs or more ) in @percent@.
Polypharmacy , age , BMI , coronary artery disease , non-HDL cholesterol , and female sex were independently associated with CKD.
Polypharmacy and falls-risk medications are potentially modifiable risk factors for falling.
Polypharmacy and hyperpolypharmacy were defined as the concomitant use of five or more and @number@ or more drugs , respectively.
Polypharmacy and increasing age had increased the risk of PIM use.
Polypharmacy can be defined as the use of two or more medications , and it is commonly seen in this patient population.
Polypharmacy has , however , been associated with increased healthcare costs , adverse drug events , and drug interactions.
Polypharmacy increases the risk of PIM administration , and as some PIMs may have cognition-impairing effects , prolonged polypharmacy may result in dementia.
Polypharmacy is also associated with increased cost.
Polypharmacy is growing in Canada , along with adverse drug events and drug-related costs.
Polypharmacy is suspected to increase the risk of adverse events ( AEs ) in older patients.
Polypharmacy , orthostatic hypotension , psychotropic drug use and anxiety were common contributory factors.
Polypharmacy , potentially inappropriate medications and anticholinergic risk scale were each associated with an increased risk of admission to hospital , but not with death.
Polypharmacy predisposes elderly individuals to PDDIs.
Polypharmacy was defined as concurrent use of @number@ or more drugs ( prescription and nonprescription ) .
Polypharmacy was defined as the use of five or more medications ( excluding ART ) .
Polypharmacy was defined as use of five or more medications.
Polyphenolic compounds incorporated into medicinal products are beneficial but , RV is rapidly metabolized with an associated decline in biological activity.
Polyphenols are a broad class of compounds.
Polyphenols are a class of natural compounds widely distributed in fruits , vegetables , and plants.
Polyphenols are effective against chronic diseases and recent reports indicated strong epigenetic effects of polyphenols.
Polyphenols are known as biomodulators with antioxidant activities.
Polyphenols are the major components of many traditional herbal remedies , which exhibit several beneficial effects including anti-inflammation and antioxidant properties.
Polyphenols are ubiquitous compounds present in the vegetal kingdom and endowed with an array of beneficial activities to human health.
Polyphenols , especially resveratrol , influence sirtuins.
Polyphenols have recently been demonstrated to protect mitochondrial health by facilitating mitophagy , thus suggesting the exciting prospect of augmenting mitophagy through dietary intake.
PolyPhen predicted that the LIM2 c.67A > C mutation may have potential pathogenicity.
Polyploidization results from cytokinesis failure that takes place progressively during the course of postnatal development.
Polypoidal choroidal vasculopathy ( PCV ) and neovascular age-related macular degeneration ( AMD ) are prevalent age-related diseases characterized by exudative changes in the macula.
Polyp specimens were taken from all patients who underwent endoscopic surgery for NPs.
Polysaccharides from Trichosanthes peel ( TPP ) were obtained by ultrasound-assisted extraction.
Polysomnographic recordings of @number@ untreated patients and @number@ age-matched normal controls were analysed.
Polysomnographic recordings were carried out continuously.
Polysomnography was used to study sleep architecture at baseline and follow-up.
Polyvinyl siloxane , applied by a gun dispenser , was used to perform a cast of the skin mark.
Pomace even presents the best antiplatelet activity.
POMC mRNA was significantly increased in both the hypothalamus and NTS region at termination.
Pomegranate juice is rich in tannins , possesses anti-atherosclerotic properties , has anti-aging effects , and potent anti-oxidative characteristics.
PON1 activity significantly decreased with advancing age , was lower in males than in females and decreased in persons with impaired cognition.
PON1 arylesterase activity was determined spectrophotometrically , anti-ox-LDL antibodies using ELISA method.
Pooled analyses are based on random effects models.
Pooled analyses were based on random effects models.
Pooled associations between menstrual or reproductive factors and lung cancer were estimated using multivariable unconditional logistic regression.
Pooled correlation and regression coefficients were calculated using meta-analysis methods for both cross-sectional and longitudinal studies.
Pooled data confirmed these results.
Pooled effect sizes suggested no significant GH effect on BMD.
Pooled effect sizes were largest , but nonsignificant , when compared to placebo.
Pooled evidence did not show a significant advantage of mindfulness training compared with control conditions in the alleviation of caregiver burden or anxiety.
Pooled mean differences between intervention and control were calculated by random-effects model.
Pooled meta-analysis was performed.
Pooled odds ratios ( ORs ) and @percent@ confidence intervals ( CIs ) were calculated by comparing the minor and major alleles.
Pooled prevalence of frailty was @percent@ for women and @percent@ for men.
Pooling of data were from different trials including different participant characteristics.
Pools of overlapping ROH segments ( consensus regions ) were identified , and the case to control ratio was calculated for each consensus region.
Poor balance control and increased fall risk have been reported in people with diabetic peripheral neuropathy ( DPN ) .
Poor clinical outcome and complicated neurological complications illustrate the severity of bone and joint infections with Aspergillus species.
Poor daily functioning and mobility was a risk factor for all-cause mortality.
Poor diet , diseases , poor living conditions , and over work were mentioned as causes of anemia.
\ "Poor \ " diet mostly had women with normal weight and middle-aged.
Poor diet quality and physical inactivity may be potential intermediators underlying the association between breakfast skipping and obesity.
Poor diet quality can exacerbate chronic health conditions in the survivors but their nutritional intake has not been adequately studied.
Poor diet quality increased risk for mortality ( HR @number@ 95%CI @number@ @number@ P = @number@ ) .
Poor elastin secretion and organization leads to a loss of specialization in contractile smooth muscle cells , resulting in over proliferation and graft failure.
Poorer cognitive function and an increased risk for vascular dementia were found to be associated with a lower consumption of milk or dairy products.
Poorer cognitive functioning across all domains was also associated with higher evening cortisol.
Poorer cognitively demanding functional abilities were associated with cognitive impairment.
Poorer concurrent weight-for-age , infection , and recent breastfeeding were associated with increased percent lactulose excretion and increased L / M ratios.
Poorer function and a greater number of behavioral and psychological symptoms predicted the probability of receiving caregiving.
Poorer function predicted having out-of-pocket NH expenditures.
Poorer global sleep quality predicted shorter telomere length in CD8 + T cells among those with high perceived stress but not in low stress participants.
Poorer health knowledge was associated with a reduced likelihood of driving over @number@ km in adjusted models.
Poorer health was associated with lower levels of sexual activity and a higher prevalence of problems with sexual functioning , particularly among men.
Poorer neuropsychological function is associated with increased medical burden ( MB ) and the use of more anticholinergic medications.
Poorer NP performance among HIV-infected individuals is associated with increased risk for social services.
Poorer physical health , higher number of medications , more severe dementia and use of antidepressants were associated with higher depression score.
Poorer physical health was associated with a lower response rate.
Poorer QOL was predicted by more functional limitations and greater levels of psychological distress.
Poorer SEP was associated with poorer subjective health and well-being.
Poor fat viability produces an inadequate result and thus can be considered as a complication of this procedure.
Poor food intake in residents living in long-term care ( LTC ) homes is a common problem.
Poor GST performance in the yaw plane was associated with balance capacity with eyes closed.
Poor knowledge and negative attitudes toward pressure ulcer prevention could undesirably affect preventive care strategies.
Poorly defined concepts can result in misunderstandings in the clinical setting and can hinder research through difficulties identifying or measuring the concept.
Poorly performing persons are further examined by segmental bioimpendance spectroscopy to determine their skeletal muscle index.
Poorly planned suicide attempts also predicted increased fronto-opercular responses.
Poor mental health including depression and social isolation can blight older people's lives.
Poor nutritional risk trajectories are associated with higher risk of mortality for very old men over a short period of time.
Poor nutritional status is one of the main risk factors for frailty.
Poor nutrition was found to be increased due to the common health problems.
Poor older adults who reduced participation in , or decreased contact with , social networks were likely to belong to the steeply-increasing group.
Poor oral health , including caries , tooth loss , and periodontitis , is ubiquitous worldwide , and is potentially treatable and preventable.
Poor oral health might be considered as a related factor of neurodegenerative symptom among older Chinese population.
Poor outcome was defined as composite of in-hospital death and severe disability ( GOS ≤ @number@ ) .
Poor perceptions of general health and low energy levels predicted low levels of resilience regardless of age.
Poor performance may reflect slowed processing speed , difficulty dividing attention , and difficulty ignoring irrelevant information.
Poor performance of sit-to-stand ( STS ) has been identified as one of the predictors of fall risk among elderly adults.
Poor performance was defined as a gait speed < 1 m / s after @number@ y of follow-up ( n = @number@ ) .
Poor performers showed a higher slope for the positive association between WMSA volume and age compared to good performers.
Poor-prognosis M3-UM divide into subsets with divergent genomic aberrations , transcriptional features , and clinical outcomes.
Poor proliferation of DC cells can be partially overcome by reducing O ( @number@ ) tension from @percent@ to @percent@.
Poor recall performance was evident even in high-cognitive ( MMSE > 27 ) patients.
Poor retrieval was the sole predictor of conversion to dementia over @number@ years.
Poor RL can be predicted by neuropsychological testing.
Poor RL performance was best predicted by impairments in memory and executive functions.
Poor scores were defined using percentiles as cut-off.
Poor sexual performance , decreased morning erection , and loss of libido had an impact on the testosterone threshold for CVD risk.
Poor sleeper was defined by a CPSQI global score of > 5.
Poor sleep has been linked to adverse health outcomes among older adults ; however , we know little about the social processes that affect sleep.
Poor sleep quality and insufficient amounts of sleep have been noted in humans with preclinical evidence of AD.
Poor sleep quality and orthostatic hypotension are common complaints in an older population , and both are related to factors such as polypharmacy and depression.
Poor sleep results in increased risk of significant morbidity and mortality.
Poor SRH was associated with low age , low income , not working , poor functional capacity , and depression in both men and women.
Poor stereovision was often associated with binocular problems such as tropia , but with many exceptions.
Poor understanding of the pathophysiology underlying VaD is hindering the development of new therapies.
Poor vision impairs balance and increases the risk of falls and fractures in older people.
POP is more difficult to assess with prevalence estimates ranging from @number@ to @percent@.
Popliteal artery flow-mediated vasodilation decreased significantly after the exercise with BFR but not after the control session.
POP related quality of life measured by VAS ( Visual Analogue Scale ) was @number@ points ( median @number@ ) .
Popular media play an important role in preventive health communication.
Population ageing affects the entire world population.
Population ageing has emerged as a major demographic trend worldwide due to improved health and longevity.
Population ageing is a new challenge for physicians because of the clinical complexity of the elderly.
Population ageing is occurring in all countries , regardless of the level of economic development.
Population ageing is probably the single most important healthcare challenge the developed and developing world will face in the 21 ( st ) century.
Population ageing poses many challenges.
Population age structure , however , was consistently older in Hermosillo.
Population aging accounted for @percent@ of this increase , next to rising prices ( @percent@ ) , and volume growth ( @percent@ ) .
Population aging and a shortage of caregivers result in a growing demand for institutionalization , and finitude is one the reflections that permeates aging.
Population aging and treatment efficacy are leading to ever growing numbers of older adults with BD.
Population aging is accelerating rapidly in Spain , posing challenges and creating opportunities for the active aging of future generations.
Population aging is accompanied by the burden of chronic diseases and disability.
Population aging is a global phenomenon.
Population aging is a global phenomenon , and choosing appropriate medical care for the elderly is critical.
Population aging is associated with increasing numbers of geriatric trauma patients , and various studies have evaluated their short-term outcomes , assessment , and treatment.
Population aging is likely to lead to an increase in the number of people in need of assistance.
Population aging is the demographic phenomenon characterizing all countries in the world , and it is challenging the national infrastructures , in particular health systems.
POPULATION : A total of @number@ volunteer subjects from @number@ nursing homes were included in this analysis.
Population attributable fractions were calculated.
Population attributable fractions were calculated to estimate years of life lost due to physical inactivity.
Population attributable risk ( PAR ) and generalized impact fraction ( GIF ) were estimated.
Population attributable risk percentage was derived to estimate excess mortality after a diagnosis of AD dementia.
Population attributable risk percentage was @percent@ for ages 75-84 and @percent@ for ages @number@ and older.
Population-attributable risks ( PARs ) were calculated.
Population-averaged models using generalized estimating equation techniques were estimated to explore changes in Medicare expenditures over time after adjusting for casemix differences.
Population-based data on the use of orthopaedic services were obtained from health service administrative databases.
Population-based , face-to-face interview with @number@ women aged 15-49 years recruited by random sampling in cities of Hong Kong , Pakistan and Thailand.
Population-based health services data were used to identify incident non-traumatic MOF and HF in @number@ and @number@ women , respectively.
Population-based studies-epidemiologic and interventional-starting in the fourth decade would provide the best information about the impact of folate on later development of AD.
Population-based studies with longer follow-up are still needed to examine effects of late toxicity on long term survival.
Population-based survival studies of breast cancer patients are commonly restricted to age- and stage-specific analyses.
Population data at the township level were obtained from the last four population censuses ( 1982-2010 ) .
Population data ( epidemiological neuropathology ) will help to model and predict the potential impact of such therapies on dementia burden in older people.
Population DXA frequency decreased markedly after the 7th decade and was performed yearly in @percent@ of the population aged > 80 years in North Denmark.
Population genetic signatures indicated that this autoimmunity variant has been evolutionarily advantageous , most likely by augmenting resistance to malaria.
Population growth coupled with an aging population will result in an increase in coverage rates , thus the projected increase in overall prescribing costs.
Population health is decreasing , chronic diseases are increasing and desire for timely access to patient-centred , team-delivered and technology-supported care remain top concerns.
( Population Health Management @number@ @time@ @number@ ) .
Population in Occident has access to the best medical care and hygiene conditions ever.
Population-level data on obesity are difficult to obtain.
Population-level differences are apparent prior to the onset of reproduction , and age-related decline in BMD is greater among Tsimane compared with American women.
POPULATION : Nationally representative sample of Taiwanese adults aged @number@ years and older with propensity score-matched controls.
POPULATION : @number@ community-dwelling volunteers aged @number@ and older.
Population pharmacokinetic modeling was performed using non-linear mixed effects modeling ( NONMEM program ) to determine the impact of frailty on gentamicin clearance.
POPULATION : Representative weighted sample of US adults @number@ to @number@ years of age.
Populations are aging and younger cohorts use technology in managing their health , affording FI self-management opportunities.
Populations are becoming progressively older thus presenting symptoms of diminished organ function due to degenerative processes.
Populations composed of racial / ethnic minorities , disabled persons , and people with low socioeconomic status have worse health than their counterparts.
Populations in developed countries continue to grow older and an understanding of the ageing process to allow healthy ageing carries important medical implications.
Population size was modeled using logistic regression.
Population specific equations were used to estimate standing height from knee height.
Population structure and cryptic relatedness can also be controlled.
Population structure was evaluated by principal component analysis to infer continuous axes of genetic variation , and single linear regression models were applied.
Population studies have demonstrated that telomere length ( TL ) displays great diversity among different populations.
Population studies were not associated with a significant effect on atrophy.
Population surveys report greater susceptibility to loss of lean tissue and muscle strength with aging in diabetes.
POPULATION : Thirty-five elderly inpatients ( aged @number@.6±7.5 years ) compared to @number@ healthy young adults ( aged 30±3.9 years ) .
Population was divided according to gender and fitness.
Population weighted numbers , weighted prevalence , and the odd ratios ( ORs ) were calculated.
Population-wide generalizations regarding diet are impractical as individualized strategies are more likely to be successful in facilitating long-term benefits in improving blood-pressure control.
POP was the main reason for sexual abstinence only in @number@ out of @number@ patients.
Porcine placental extract ( PPE ) , an oral supplement , was recently developed for this purpose.
Pore numbers and percentages were analyzed using one-way Analysis of Variance ( ANOVA ) and Dunnett's-T3 post-hoc tests ( p < @number@ ) .
Pork is an important meat source for humans.
Pormpuraawans instead arrange time according to cardinal directions : east to west.
Pormpuraawans ' representations of time differ strikingly from all others documented to date.
Portugal displays an elevated stroke mortality rate.
Portugal is one of the European countries where more medicines are consumed and the associated expense is higher.
Posaconazole iv can be used when the oral route is contraindicated or not feasible.
Posaconazole tablets were generally well tolerated in high-risk neutropenic patients.
POS are then collected , spun , resuspended sequentially in wash buffers , counted and aliquoted.
PosiGene is a user-friendly , reliable tool for reproducible genome-wide identification of PSGs and freely available at @url@
Posited mechanisms for this association include stress , personality , psychosocial variables , coping , social networks , and health behaviors.
Position and name generators were used to collect data on social capital and social connections.
Position errors for both matching methods correlated only mildly with each other.
Position of C7 plumbline relative to sacrum and hip axis ( HA ) was also assessed.
Positive 1-year results ( significantly higher use of preventive services and better health behaviour ) were presented earlier.
Positive affect and optimism play an important role in healthy ageing and are associated with improved physical and cognitive health outcomes.
Positive affect was low on waking and peaked in the early evening , while distressed affect decreased progressively over the day.
Positive airway pressure therapy remains the gold standard currently in treating OSA.
Positive and distressed affect were only modestly correlated ( r = @number@ ) .
Positive and negative affect levels and objective cognitive fitness parameters served as possible covariates.
Positive and negative remodeling is based on how these factors coordinate and determine the direction of remodeling.
Positive and timely operation should be performed in the patient with cystic pancreatic tumor , and it acts as a cancer preventive treatment.
Positive appraisal of the amputation is experienced by many people , thus requiring more attention in future research.
Positive associations were found between F ( @number@ ) -IPs and all measures of total and regional adiposity among women.
Positive associations were stratified by age at onset and cancer family history.
Positive attitudes were most frequently related to enhanced convenience and advanced features.
Positive between-person effects of self-efficacy on physical activity were found.
Positive caregiver reactions were evaluated using the self-esteem subscale ( seven items ) of the Caregiver Reaction Assessment ( CRA ) .
Positive cases displayed increased reticulocytosis and slightly reduced hemoglobin ( Hb ) values compared to negative ones.
Positive cases included @number@ ipsilateral and @number@ contralateral BC , @number@ BC in different quadrants from those of onset of the first BC.
Positive cases showed a more evident hemolytic pattern suggesting a pathogenic role of these autoantibodies in RBC opsonization and splenic removal.
Positive connectivity of the PCC within the default mode network as well as negative connectivity towards the frontoparietal network were weaker in patients with 22q11.2DS.
Positive controls were @number@ μM verapamil and @number@ μM digoxin.
Positive correlation between the number of cigarettes smoked per day and AGEs was also found ( r = @number@ P = @number@ ) .
Positive correlation of the extent of bronchial obstruction and decrease of absolute indices of cardiac rhythm variability was established.
Positive correlations between the AAI and DFLE suggest that older adults could enjoy more DFLE by involving themselves in active aging activities.
Positive correlations were found between the levels of blood pressure , glucose and lipids and BMI.
Positive effects of the training were noted in both groups , but significantly better effects were observed in the group that performed sling training.
Positive effects on self-confidence appeared between 3-6 weeks and on fatigue after 9-12 weeks.
Positive findings warrant a thorough workup including a metabolic bone laboratory panel , and possibly a DEXA scan , which includes a lateral spine view.
Positive fluid balance has been shown to be an independent risk factor for morbidity and mortality in critically ill patients with acute kidney injury.
Positive global correspondence suggests that Aβ accumulation progresses along iFC , with this effect starting in preclinical stages , and being constant along clinical periods.
Positive health outcomes hinge on the effective use of medications especially among vulnerable , chronically ill , and aging populations.
Positive inotropic drugs have long been studied for their potential benefits in patients with heart failure and reduced ejection fraction ( HFrEF ) .
Positive interactions with the committees reinforced researchers ' need to carefully construct their research approaches with persons with dementia in particular.
Positive lymph nodes and myometrial invasion of > 50% were associated independently with the risk of recurrence after adjustment for possible confounders.
Positive , neutral , and negative faces were used as stimuli.
Positive or negative health events in the four-week interval between definitions and specific respondents ' characteristics did not vary across consistency categories.
Positive perceptions of CP in one's aging process may have implications for aging successfully.
Positive performance feedback elicited the strongest striatal and amygdala activation , which was reflected behaviorally in slightly faster reaction times.
Positive perspectives of ageing are underpinned by a range of appraoches to successful ageing.
Positive predictive values ( PPVs ) of diagnostic codes , laboratory abnormalities , and their combinations for confirmed outcomes were determined.
Positive predictive value was @percent@ , and negative predictive value was particularly high at @percent@.
Positive reactions to caregiving have been shown to protect people against anxiety and depression.
Positive relationships emerged most consistently between the hippocampal formation and global cognition and memory and between frontal measures and executive function.
Positive results led to approval of NIBS for some of these conditions by the Food and Drug Administration in the USA.
Positive serum anti-Hu antibody , poorer tumor stag , and together with poorer response to treatments seem to indicate a poorer prognosis.
Positive significant correlation was observed between serum fructose and s-AGEs in diabetic and non-diabetic patients with myocardial infarction.
Positive small effects ( d = @number@ to d = @number@ ) were also found for work related mental strain.
Positive spousal support significantly weakened the deleterious effect of MCC on depression.
Positive support mediated the link between type proportions and health limitations , whereas trust mediated the link between type proportions and depressive symptoms.
Positive word use in narratives was associated with valence ratings only in young adults ' narratives.
Positivity effects were pronounced for S-O learning , whereas S-R learning correlated with working-memory capacity in both age groups.
Positron emission tomography-amyloid imaging was conducted in @number@ SCI and @number@ nonSCI subjects.
Positron emission tomography ( PET ) imaging has been used to compare resting brain glucose metabolism.
Positron emission tomography ( PET ) is a powerful analytical tool for in vivo molecular imaging of the human brain.
Positron emission tomography ( PET ) to detect amyloid β was first developed in @number@ ( @number@ ) ) .
POS obtained this way can be used for phagocytosis assays and analysis of protein activation , localization or interaction at various times after POS challenge.
Possession of an apolipoprotein E ( APOE ) ɛ4 allele is the strongest genetic risk factor for late onset AD.
Possible and probable dementia was assessed according to a validated algorithm.
Possible associations were investigated in fixed-effects meta-analyses.
Possible avenues by which GDP affects SWB are also explored.
Possible biological mechanisms include de novo aberration and mutations or epigenetic alterations associated with aging.
Possible cause of osteopenia may be exposure to As.
Possible causes are hypoxemia , hypercapnia , exacerbations and decreased physical activity.
Possible contamination from phlebotomy devices with Cr should be taken into account in evaluating the results.
Possible dementia prevention strategies should point to a life course perspective on maintaining vascular health.
Possible downstream targets and pathways of these miRNAs were predicted by performing bioinformatics analysis.
Possible explanations and implications of the relationships in the context of cognitive aging in healthy adults , and limitations of cross-sectional research are discussed.
Possible explanations for this lack of difference and future directions are discussed.
Possible explanations were further provided for the mismatch between Chinese values and the existence of SEB.
Possible factors of importance could be the effect of sex hormones , as well as differing collagen isoforms , between the sexes.
Possible factors that are associated with life-course socio-economic disadvantage and late-life cognitive decline included household income and perception of economic strain.
Possible implications on pathogenetic clues of atherothrombosis can be assumed.
Possible limitations of the previous study were : time of treatment ( @number@ months ) or spectrum of DNA lesions detected.
Possible mechanisms to account for the effects of monocular vision on saccades are discussed.
Possible mechanisms underlying associations of personality characteristics with cognition are reviewed , and assessed in the context of the current literature.
Possible pathogenetic mechanisms include artery-to-artery emboli , especially microemboli that may include atheroemboli or platelet-fibrin emboli.
Possible pathophysiologic mechanisms common to both T2DM and AD are glucose toxicity and a direct effect of insulin on amyloid metabolism.
Possible pitfalls in neuropathic pain treatment in the elderly will be underlined.
Possible practice effects of repeated cognitive testing were addressed with the reliable change index.
Possible reasons for this pattern will be discussed.
Possible referral bias due to inclusion of relatively high risk elderly patients.
Possible research ageing areas are : @number@ ) evaluation of psychosocial risk-protective factors related to the individual's biography and personality.
Possible role of gene-environment interaction effects driven by historical events are discussed.
Possible solutions to maximizing compliance are explored.
Possible sources of estimation errors are discussed.
Possible therapeutic options to reverse or halt uremia-associated immunological ageing are discussed.
Possible therapeutic options to reverse or halt uremia-associated immunological aging are discussed.
Possible trial design and methodological considerations that may have affected results are discussed.
Possible underlying mechanisms are discussed , and directions for future research are suggested.
Possible underlying mechanisms , including brain-derived neurotrophic factor and sex steroid hormones , are discussed.
Possible underlying mechanisms of the found sex differences are discussed and directions for future research are given.
Possibly , a problem with pharmacological activators is that they cause generation of mitochondrial reactive oxygen species.
Possibly genetic factors such as parental longevity and birth order appear to be less predictive in men than in women.
Possibly , nutritional counselling should be accompanied with nutritional supplementation to be effective in this vulnerable group of elderly.
Possibly , this increase reflects attempts to compensate for poor performance of certain neurocognitive processes , such as feature binding.
Post-acute care is a poorly understood but very important aspect of our healthcare system.
Postacute care providers felt that the videoconference enhanced communication and provided much-needed access to information and hospital staff.
Post-arousal , all frequency bands below @number@ Hz transiently fell below pre-arousal baseline in both age groups.
Postcolonial discourse tells us that this is not quite as easy as some versions of so-called \ "Happy Gerontology \ " proclaim.
Post-communist and Southern countries experienced both lower life satisfaction and larger socioeconomic inequalities in life satisfaction , using most measures of socioeconomic position.
Postconcussive cognitive function also differs by gender.
Post-discharge care is often fragmented leading to increased healthcare costs , readmissions , and sub-optimal utilization of rehabilitation and community services.
Posterior brain arteries had thinner walls , less elastin , and more concentric intima thickening than anterior brain arteries.
Posterior cingulate cortex ( PCC ) accumulates amyloid-β ( Aβ ) early in Alzheimer's disease ( AD ) .
Posteriori approach derives a dietary pattern independently of the existing nutrition-disease knowledge.
Posteriorly , after bacterial vital staining , samples were analyzed using a confocal laser scanning microscope.
Posterior midline synchondrosis of the atlas closed after @number@ years ( range 2-13 years ) .
Posterior movement of the lamina ( LD-BM increase or LD-AS increase ) occurred with the same frequencies as thinning in neuroretinal parameters.
Posterior regions of the CR and IC demonstrated significantly lower RD values compared to anterior regions.
Posterior scleral shells from five diabetic donors and seven non-diabetic donors were pressurized to @number@ mm Hg.
Posterior subcapsular cataract was more common than in western studies.
Posterior subcapsular opacity incidence and cataract surgery rate were comparable.
Posterior surface astigmatism and lens astigmatism were not age-dependent.
Posterior vitreous detachment ( PVD ) is a common phenomenon in the aging eye.
Posteromedial cortices ( PMCs ) are particularly vulnerable to early amyloid pathology and play a role in both encoding and retrieval processes.
Post evaluation , XEO was administered at @number@ intramuscular injection sites with equal aliquots of @number@ units per @number@ mL.
Postgraduate Year @number@ internal medicine residents ( n = @number@ ) delivered @number@ sessions.
Post hoc across-group comparison of baseline change also highlights the benefits of REAL training.
Post-hoc analyses indicated that PFAS trajectories were heterogeneous by age.
Post hoc analyses indicated that these latter domains were affected differentially by CPT and CT.
Post-hoc analyses of behavioral data showed lower percentages of correct responses and higher response times in the older group.
Post-hoc analyses of functional connectivity confirmed the distinguishable cross-lifespan trajectories between the two networks.
Post hoc analyses were performed for mild cognitive deficits , baseline MMSE score≥24 and ≤27 , to estimate the OR and CI for MMSE score≤23.
Post-hoc analysis demonstrated that this effect was driven by COS patients ( p < 0.001 ) .
Post hoc analysis revealed that differences shown were between the young group and both older groups.
Post hoc analysis was performed using Tukey test.
Post-hoc calculations demonstrated @percent@ statistical power to detect a genetic variant associated with effect size of @percent@ for fish and @percent@ for EPA + DHA.
Post hoc comparisons showed that the olanzapine group had the highest levels of cholesterol and triglycerides.
Post hoc comparisons showed that the olanzapine group had the lowest levels of adiponectin and total ghrelin.
Post-hoc test revealed that torque amplitude differed between sexes only in the young ( P < @number@ ) .
Post hoc tests revealed that fear-potentiation increased in girls but not boys over the course of puberty.
Post-ictal confusion and memory lapses are particularly prolonged in the elderly.
Postictal EEG suppression durations were on average 28s shorter in children.
Post-ICU frailty may be a useful trigger for palliative care consultation and a treatment target.
Postintervention measures indicated the technology was easy to use , significantly facilitated meaningful and positive engagement , and simplified caregivers ' daily lives.
Post-intervention , no significant within-group or between-group changes were observed in mBDNF or tBDNF.
Postintervention , residents experienced a significant increase in overall QOL.
Postischemic microvascular expression of ER-α in OVX rats ( @number@ ± @number@ ) was increased by CE treatment ( @number@ ± @number@ ) .
Postmenopausal changes significantly decrease physical efficiency and impair the body's mechanisms for maintaining postural stability.
Postmenopausal hypertension is likely multifactorial.
Postmenopausal osteoporosis is of particular concern because it leads to an increased risk of fractures , with subsequent negative impacts on health in older women.
Postmenopausal women ( aged 48-60 years ) were randomly assigned to WBV training , circuit resistance training , or aerobic training.
Postmenopausal women aged ≥50 years had a particularly elevated OR for dysglycemia , regardless of age at menopause.
Postmenopausal women are at the greatest risk of developing osteoporosis due to the cessation in ovarian hormone production , which causes accelerated bone loss.
Postmenopausal women are particularly at risk for this type of fracture.
Post-menopause is the period of life where a deep decline occurs in circulating estrogen levels , inducing the appearance of psycho and somatic symptoms.
Post-menopause physiological changes are particularly noticeable in the skin , which loses structural architecture and becomes prone to damage.
Post-MI leukocyte density , residence time in the infarcted area , and exit from the infarcted injury predict resolving or nonresolving inflammation.
Post-mortem brain tissues from post-stroke dementia and post-stroke patients with no dementia were derived from our prospective Cognitive Function After Stroke study.
Postmortem culture and genotyping analyses allowed us to identify Klebsiella pneumoniae as the cause of sepsis , revealing the inadequateness of antimicrobial therapy.
Postmortem diagnosis was available for @number@ patients ( @percent@ ) .
Post-mortem evaluations of healthy grafted tissue in such cases have revealed the development of Huntington- or Parkinson-like pathology including mutant huntingtin aggregates and Lewy bodies.
Postmortem examination of the brain biopsy from a patient carrying the gene deletion revealed widespread α-synuclein pathology.
Post-mortem hypothalamic tissues were collected at the Netherlands Brain Bank and were stained for vimentin by immunohistochemistry.
Postmortem studies revealed patchy axonal degeneration and myelin loss , predominantly in the subcortical white matter.
Post-mortem tissue analysis indicates BBB damage in Alzheimer's disease ( AD ) .
Postmortem tissue and clinical data were provided by the Oregon Health and Science University Layton Aging and Alzheimer Disease Center and Oregon Brain Bank.
Postmortem tissue from available patients displayed classic TAR DNA-binding protein @number@ pathology.
Postnatal day @number@ microglia demonstrated a CD47 dependent ability to phagocytose Aβ fibrils that was lost by @number@ months.
Postnatal ventilation , oxygen , parenteral nutrition , ibuprofen , steroids , ROP , and intraventricular hemorrhage were different.
Postoperative adverse effects were also recorded.
Postoperative age-specific complications and their management will be reviewed.
Postoperative anemia occurred as the most common AE ( n = 32 ; @percent@ ) .
Postoperative atrial fibrillation ( PoAF ) , a common complication of cardiac surgery , contributes significantly to morbidity , mortality , and increasing healthcare costs.
POSTOPERATIVE CARE : Proper postoperative care is important in avoiding complications.
Post-operative cognitive dysfunction ( POCD ) is associated with increased cost of care , morbidity , and mortality.
Postoperative cognitive impairment is a recognized clinical phenomenon.
Postoperative complications included one hematoma that responded to drainage.
Postoperative complications lead to longer hospitalizations and greater costs.
Postoperative complications occurred in @number@ patients ( @percent@ ) .
Postoperative complications were observed in @number@ percent and minor complaints in @number@ percent.
Postoperative complications were occurred in @number@ cases ( @percent@ ) .
Postoperative decline was defined as a decline in scores of cognitive tests of ≥25% on ≥2 of @number@ tests.
Postoperative delirium occurs frequently , resulting in major morbidity for vascular patients.
Postoperative delirium severity and occurrence were assessed during the hospital stay using the Confusion Assessment Method and a validated chart review method.
Postoperative fast track helped avoid the typical complications affecting this patient subset.
Postoperative first phase insulin secretion rate ( ISR ) during the IVGTT and β-cell glucose sensitivity during the OGTT increased in T2DM.
Postoperative follow-up EEGs were performed in @number@ patients.
Postoperative follow-up for the patients ranged from @number@ to @number@ months ( mean @number@ ± @number@ months ) .
Postoperative inotrope requirement and major morbidity endpoints were assessed.
Postoperative insulin sensitivity and the disposition index ( DI ) markedly increased in both groups.
Postoperatively , surgical complications were classified according to the Clavien-Dindo classification.
Postoperatively , the tinted IOL group had a significantly higher green : blue ratio than the untinted IOL group ( P < @number@ ) .
Postoperative monitoring of pro-inflammatory markers combined with regular surveillance may be helpful in the early detection of postoperative delirium in this patient group.
Postoperative morbidity ranged between @number@ and @percent@.
Postoperative mortality and morbidity occurred in @number@ ( @percent@ ) and @number@ ( @percent@ ) patients , respectively.
Postoperative mortality and morbidity rates were in total @number@ and @percent@ , respectively.
Postoperative mortality at @number@ days declined despite increased median age at diagnosis.
Postoperative neurologic and systemic morbidity was @percent@ and @percent@ , respectively.
Postoperative outcomes in terms of normal bowel function and length of hospital stay were significantly improved in the ERAS group.
Postoperative outcomes were evaluated through clinical questionnaires , a rigid rectosigmoidoscopy and a defecography , @number@ year after surgery.
Postoperative outcomes were noted.
Postoperative parathyroid hormone decrease , surgical complications and symptoms control were analyzed for all patients in relation to the types of parathyroidectomy performed.
Postoperative platelet counts were evaluated as continuous and categorical ( mild versus moderate to severe ) predictors of stroke.
Postoperative postprandial GLP-1 concentrations increased markedly , but did not differ between the groups.
Postoperative radiography using iodine-based contrast media showed that the gastrointestinal tract was unobstructed.
Post-operative remission of hyperprolactinemia was achieved in @percent@ of patients with NFPAH and in @percent@ of patients with PRS.
Post-operative suites were simple.
Postoperative sun avoidance and use of sunscreen is mandatory.
Postoperative visits were scheduled at @number@ week and @number@ month.
Postprandial hypotension is an important problem , particularly in the elderly.
Postprandial insulin release is lower in healthy aerobically trained ( T ) compared to untrained ( UT ) individuals.
Postprandial muscle protein synthesis rates were higher in the Pro-En vs En group ( P = @number@ ) .
Postprandial serum AA profiles were evaluated in twelve healthy , older subjects who participated in a randomized , controlled , single blind , cross-over study.
Postprocedural complications were statistically lower in the elderly patients than in younger patients ( P = @number@ ) .
Post-reproductive life span has been observed in a broad range of vertebrate and invertebrate species.
Postretirement sleep improvement was explained by the combination of preretirement risk factors suggesting removal of work-related exposures as a mechanism.
Postsecondary enrollment at age @number@ did not predict gains in perceived control over time.
Poststroke differences in IADL independence largely reflect prestroke disparities.
Postsynaptic scaffolding proteins regulate coordinated neurotransmission by anchoring and clustering receptors and adhesion molecules.
Post-tests will be conducted right after the intervention period.
Posttraining , gait speed significantly improved during usual walking , during dual task , and while negotiating overground obstacles.
Post-training , YT and MAT had comparable basal GH ( P > 0.05 ) .
Post-transcriptional gene regulation by microRNAs ( miRNAs ) and RNA-binding proteins ( RBPs ) is central to many biological functions.
Post-transcriptional gene regulation is an important step in eukaryotic gene expression.
Post-transcriptional gene regulation is robustly regulated by RNA-binding proteins ( RBPs ) .
Posttranslational histone modifications have been found to differ between the brain tissue of human embryos with neural tube defects and that of controls.
Posttranslational modifications including phosphorylation and acetylation regulate FoxO activity by a cytoplasmic-nuclear shuttle mechanism.
Posttranslational modifications of circulating proteins such as immunoglobulins may prove to be important biomarkers of aging.
Post-translational modifications of histones play a key role in the regulation of gene expression during development and differentiation.
Posttranslational modifications of the NICD are important for its transcriptional activity and protein turnover.
Post-translational modifications ( PTMs ) critically regulate IF dynamics in response to physiological changes and under stress conditions.
Posttranslational protein modifications are playing crucial roles in essential cellular mechanisms.
Post-transplant diabetes mellitus occurs in 30-50% of cases during the first year post-renal transplantation.
Post-traumatic epilepsy ( PTE ) accounts for 10-20% of symptomatic epilepsies.
Post-traumatic neurological deficit was present in @percent@ patients.
Post-traumatic stress disorder ( PTSD ) and social support were examined as moderators between combat exposure and outcomes.
Posttraumatic stress symptoms play a prominent role for quality of life and well-being in this population.
Post-treatment edema and redness settle in a few hours to a few days.
Post-treatment edema and redness settle in a few hours to a few days.
Post-treatment erythema was seen in all subjects and disappeared within @number@ h.
Posttreatment gains were maintained at follow-up.
Posttreatment hemorrhage occurred in @number@ %.
Posttreatment skin responses and side effects were assessed at treatment and follow-up visits by study physicians.
Postulated advantages using laser devices are a more precise cutting line as well as better hemostasis.
Postulated mechanisms include the inhibition of nuclear factor NF-kappa-B.
Postulating that the presentation depends on the age of the affected patients , the authors reassessed the presentation of @number@ consecutive patients.
Postupdating performance sharply declined with age but did not reliably differ between physical and imagined updating.
Postural and force performance deteriorated with age and task difficulty in dual-task contexts.
Postural control after stepping down was measured with and without performing a concurrent auditory response task.
Postural control ( center of pressure area ) was analyzed under four dual-task conditions.
Postural control in certain situations depends on functioning of tactile or proprioceptive receptors and their respective dynamic integration.
Postural control was assessed with a variety of instruments , mainly evaluating aspects of body sway during quiet standing.
Postural control was less altered for the young active group than for the other groups.
Postural instability associated with age typically arises from deterioration of peripheral sensory systems.
Postural instability or motor slowness are some clinical manifestations , being consubstantial with the frailty phenotype , genuine expression of aging.
Postural manoeuvres were performed to induce haemodynamic fluctuations.
Postural parameters were deduced from the analysis of the centre of foot pressure ( CoP ) displacement.
Postural response latency was not correlated with the T25FW.
Postural stability effects were evaluated by conventional and statistical mechanics sway measures , as well as trunk angular displacement parameters.
Postural stability led to improved performance in younger subjects during the dual-task and but not in the elderly.
Postural stability was assessed before and after training with an optoelectronic platform and a uni-pedal balance performance test.
Postural stability was measured at onset , after @number@ months , and after @number@ months.
Postural stability was used as a primary outcome , with QoL and falls used as secondary outcomes.
Postural sway speed and area , which did not correlate with complexity , were also computed.
Postural sway was assessed before and after the training during standing on a force-plate with eyes-open ( EO ) and eyes-closed ( EC ) .
Postural trials were performed before and after fatiguing exercises of different intensities : @number@ @number@ and @percent@ of maximal isometric plantarflexor torque.
Postural VC difference and percentage were calculated from the VC data.
Posturography demonstrated two major findings : the body support area was limited and the use of vision for postural control was reduced.
Posturography outcome indicated that training alters the postural strategy by reducing the oscillatory fluctuations of body sway signal.
Posturography parameters analyzed included center of pressure and velocity of body sway.
Posturography was measured with a force platform and eye movements were measured by video-oculography.
Post-vaccine antibody responses were inversely correlated with pre-vaccination plasma TNFα levels and with activated CD4 T cells , including activated peripheral ( p ) Tfh.
Post-viewing their photoaged facial image many teenagers reiterated their intentions to adopt ( when they remembered ) skin-protective measures.
Postzygotic mutations in somatic cells lead to genome mosaicism and can be the cause of cancer , possibly other human diseases and aging.
Pot1a is highly expressed in young HSCs , but declines with age.
POT1 inhibition exacerbates telomere dysfunction induced by ICRF-193.
Potassium channels are one of the largest subfamilies of voltage sensitive channels and are among the most-studied of the voltage-gated ion channels.
Potassium intakes were generally low ( median @number@ mmol / day ) with significantly lower intakes in rural areas and older adults.
Potato intake was directly associated with SCFA concentrations and apple intake with propionate concentration.
POTEF-AS1 promoted cell growth , repressed genes related to the Toll-like receptor signaling and apoptosis pathways , and inhibited apoptosis in docetaxel-treated LNCaP cells.
Potent antiretroviral therapy has shifted the severity of HAND to milder phenotypes , but excess morbidity and mortality continue to be associated with HAND.
Potential advantages in tissue classification and segmentation were obtained for MP2RAGE.
Potential antiinflammatory and antioxidant effects were recently ascribed to naturally occurring micronutrients.
Potential applications of our approach include basic research and clinical settings on visual and nonimage-forming visual systems.
Potential associated characteristics included measurements of demographics , socioeconomic position , health behavior , and health status.
Potential barriers were derived using Grounded Theory.
Potential benefits have to be weighed against risks , including addictive potential and treatment-emergent mania.
Potential biological and technical issues are discussed.
Potential causes of sarcopenia include age-related changes in the hormonal status , low levels of physical activity , reduced protein intake and increased oxidative stress.
Potential causes of variations in predictability include intrinsic ( patient-related ) or extrinsic factors , such as harvesting , processing , and graft-delivery technique.
Potential clinical implications include an increased risk of cerebral hypoperfusion , which predisposes older adults to falls , faints , and changes in cognitive status.
Potential confounders were included in multivariable models and updated at each follow-up visit.
Potential confounding variables included age , sex , conventional stroke risk factors , and high sensitive C-reactive protein.
Potential confounding variables included a wide range of socio-demographic variables and health indicators.
Potential confounding variables included dietary intake , accelerometer-based physical activity , and molecularly defined lactase nonpersistence.
Potential contributors to this intersubject variability include white matter hyperintensities ( WMH ) and preclinical Alzheimer's disease , evident as increased brain amyloid.
Potential correlates were evaluated in physical and psychological domains.
Potential covariates ( gender , education , health conditions , and depressive symptoms ) did not account for these differential lead-lag associations.
Potential covariates included demographic , psychosocial , and clinical factors , diagnosis year , and care setting.
Potential demographic and health-related confounds were measured at baseline ( partnership status , SES , mortality risk index , and medication ) .
Potential determinants of plasma NGAL included sociodemographic characteristics , lifestyle and psychiatric and physical comorbidity.
Potential DRPs were classified using the DOCUMENT classification.
Potential drug-supplement interactions were identified in @number@ ( @percent@ ) patients.
Potential effectiveness was tested measuring the level of physical activity , frailty , quality of life , and mobility before and after treatment.
Potential effect modification by six single nucleotide polymorphisms ( SNPs ) in three microRNA-related genes was investigated.
Potential effects of such representations are discussed using social cognitive theory and cultivation theory.
Potential explanations for these findings are discussed.
Potential factors associated with speech recognition results were assessed by an auditory measure of temporal fine structure and a neuropsychological profile.
Potential for pharmacological HDAC inhibition as a means of treating age-related cardiac dysfunction is also discussed.
Potential Human Cellular Senescence Genes ( HCSGS ) were collected by combining information from published literatures , gene expression profiling data and Protein-Protein Interaction networks.
Potential implication for treatment of Fanconi anemia-deficient tumors by their sensitization to DNA cross-linking agents is discussed.
Potential implications of these findings for clinical practice are discussed.
Potential implications of this research include HRV response to alcohol that could serve as a marker for susceptibility to alcoholism.
Potential interactions between time-varying PA and age ( < 70 , ≥70 ) were also tested.
Potentially avoidable hospitalizations and Medicare costs were assessed over @number@ to @number@ months.
Potentially discordant single-base substitutions supported by both platforms were validated extensively by Sanger , Roche @number@ and Ion Torrent sequencing.
Potentially important differences were noted comparing women with men , black with white , and aging populations.
Potentially inappropriate medication ( PIM ) use frequently leads to adverse drug events and geriatric syndromes.
Potentially inappropriate prescribing for older adults is a major public health concern.
Potentially inappropriate prescription was observed in @percent@ of patients ( @percent@ overprescription and @percent@ underprescription ) .
Potentially , reducing entrance-related barriers may help to prevent confinement to the home.
Potentially reversible cognitive impairment is MCI ( CDR = 0.5 ) .
Potentially , this is suggestive of a unique ability within the sample to adapt to aging and its limitations.
Potentially , this technology identifies children who are at increased risk for complications.
Potentially , underlying alterations in autonomic tone and / or subclinical sinus node dysfunction manifested as slow heart rate predispose to AF.
Potential mechanisms are discussed.
Potential mechanisms , including lifestyle factors , are discussed.
Potential mechanisms linking nutrition and frailty as well as directions for future research are discussed.
Potential mediators of the relationship between Tai Chi Chuan and cognition , including physical resources , disease status , and mental resources , are discussed.
Potential moderators from demographic characteristics and program dosage effects were assessed using multiple linear regression models.
Potential numerical issues and computational cost were also assessed through simulations.
Potential oocyte freezers are characterized by a higher number of desired children and more openness to oocyte donation.
Potential parents and policymakers can use this information to time births more appropriately , thereby reducing risks to babies and mothers.
Potential participant registries represent an increasingly common intervention to overcome this barrier.
Potential participants were initially screened by telephone , and those who met the inclusion criteria were included.
Potential pathways are considered.
Potential patients were identified via AAA surveillance lists and vascular clinics and invited to participate in the study.
Potential predictors included sociodemographic variables , in-hospital and clinical pre- and post-fracture data , and activities of daily living at baseline and follow-up.
Potential predictors of non-adherence were investigated using logistic regression analysis.
Potential predictors were : health , personality , work characteristics , and demographics.
Potential predictors were investigated using multilevel modelling.
Potential reasons for these problems are numerous.
Potential-related signaling pathways were also examined.
Potential reserves of longevity are estimated and possible ways to achieve them are provided.
Potential respondents were contacted by e-mail and provided with an electronic nontransferable secured link to the survey.
Potential risk factors for cataract were determined by multiple logistic regression analysis of data obtained from the health examination , blood biochemistry and interviewer-administered questionnaires.
Potential risk factors included menopausal stage , age , race , reproductive hormone levels , body mass index ( BMI ) , and current smoking.
Potential risk factors of bladder underactivity include : ageing , diabetes , neurogenic disease , cardiovascular disease , obstruction and psychological causes.
Potential risks of bleeding due to the use of Ginkgo biloba , garlic or ginseng with aspirin or warfarin was the most reported herb-drug interaction.
Potential safety concerns of long-term PPI use have been reported in the literature.
Potential sources of electromagnetic interference and special considerations pertaining to the cardiac resuscitation of patients with implanted cardiac devices are reviewed.
Potential strategies to assist knowledge transfer in long-term care settings are needed.
Potential targets for treatment are described , and possible therapeutic approaches are discussed.
Potential therapeutic use of human adipose tissue-derived stem cells ( hADSCs ) requires the production of large cell numbers by in vitro expansion.
Potential underlying mechanisms for this interaction are evaluated.
Potential vascular complications were documented in only two patients.
Potentiation of glucose-stimulated insulin secretion concomitant with enhanced islet cAMP level by all-trans retinoic acid ( ATRA ) was attenuated upon Gprc5c-KD.
Potentilla parvifolia Fisch.
Poverty , female sex , current alcohol use , and diabetes or anti-hypertensive medication use were associated with not meeting goals.
Power analyses showed that the relationship of follow-up duration and statistical power can be counterintuitive in the presence of realistic amounts of attenuation.
Power declines more steeply than strength with advancing age and training cessation among older women and is associated with the loss of functional ability.
Powerful antioxidant mechanisms have been developed in order to avoid oxidative stress by contributing to the maintenance of redox homeostasis.
Power operates in discursively producing subject positions of older people and associated subjectivities which can shape nursing practice.
Power spectral analysis revealed weekly periodicity in the PA series ( corresponding to festivity rest ) but not in the AF incidence.
Power spectra were computed in the frontal and parietal regions and correlated with recognition performance.
Power spectra were obtained from sleep EEG ( central derivation ) , using a 2-second sliding window , with 1-second steps.
Power was assessed for leg press and chest press.
Power was insufficient to analyze BRCA1 and BRCA2 mutation carriers separately.
PPACA is encouraging improvement and reduced unnecessary hospitalizations through incentives and penalties.
PPARs and cognate ligands also regulate important cellular functions , including cell proliferation and differentiation , as well as inflammatory responses.
PPARs are expressed in various cell types in the skin , including keratinocytes , fibroblasts and infiltrating immune cells.
PPARβ / δ expression increased p-ERK and decreased p-AKT activity.
PPARγ agonists can appear as promising treatment against the initiation and the progression of CNV in exudative AMD.
PPAR-γ agonists may mediate vascular effects in addition to insulin sensitizing.
PPAR-γ agonists such as rosiglitazone and pioglitazone are generally well-tolerated in AD and aMCI patients.
PPARγ inactivation by GW9662 inhibited the troglitazone-induced @date@ mRNA expression.
PPARγ induced HO-1 and autophagy molecules but reduced inflammatory molecules in aged cells.
PPARγ is another transcription factor involved in hypoxic remodeling.
PPARγ levels are directly regulated by Wnt molecules ; therefore , changes in the Wnt microenvironment have close control over maintenance of the distal lung.
PPARγ ligands have inhibitory effects on platelet aggregation via the cAMP pathway , which may confer them a protective cardioprotective role.
PPAR-γ may be a new target in treating age-related cerebrovascular dysfunction.
PPF scores ( ranging from 0-16 , with higher indicating better performance ) included walking speed , chair rises , grip strength , and balance.
PPG-5-CETETH-20-based systems may be a promising platform for KA skin delivery.
PPI has never been studied in patients with multiple system atrophy ( MSA ) , although sensorimotor deficits are frequently associated with synucleinopathies.
PPI may be a non-invasive neurophysiological measure that can aid in the differential diagnosis between PD and MSA.
PPIs have been shown to decrease antiplatelet effects of clopidogrel ex vivo , raising concerns about the cardiovascular safety of this drug combination.
P. polonicum strains were also highly toxigenic.
PPV23 rate was defined as the number of participants who reported receiving free PPV23 divided by the total number of candidates for free PPV23.
PPVP diameter was divided into nasal length and temporal length based on the center of the fovea.
Practical advice on how nurses can best assist older people is presented.
PRACTICAL APPLICATIONS : Total Worker Health includes not only the worker , but also the family.
Practical applications to these procedures are also provided.
Practical Implications.
Practical implications are suggested.
Practical implications from state , destination , and individual levels to better facilitate seasonal mobility and promote wellbeing are provided.
PRACTICAL IMPLICATIONS : Long-term adhesion to ceramic plays an important role in the longevity of dental restorations.
Practical implications of these data are discussed.
Practical methods to define genotypes will be increasingly important and non-invasive nanotechnologies are needed to detect molecular changes that predate histopathology.
Practical points , such as the need for blinding of lifespan studies and for appropriate biomarkers , are also considered.
Practical service implications and the need for greater developments with respect to the awareness and understanding of dementia in rural , northern communities are discussed.
PRACTICE : An equation was developed to adjust for winter weather conditions using temperature , humidity and time of day.
Practice effect is less pronounced in patients with advanced disease.
Practice effects were measurable but uniform across the observed age cohorts.
Practice guidelines are needed to inform clinicians and patients about safe and effective therapies.
Practice guidelines for care-home residents with DM are needed to ensure quality of care.
Practice guidelines recommend screening older adults with symptoms of cognitive disorder for B12 deficiency.
PRACTICE IMPLICATION : Clinicians need to recognize the indicators of low health literacy and utilize the available assessment tools.
PRACTICE IMPLICATIONS : Care for the elderly can be exhausting physically and emotionally ; system-wide changes and standards are important in minimizing its impact.
PRACTICE IMPLICATIONS : If these associations hold true , then promoting further educational attainment of individual administrators may influence quality of care.
PRACTICE IMPLICATIONS : Our study was designed for the time constraints of today's clinical practice setting.
PRACTICE IMPLICATIONS : The SMW group intervention can be transferred to health and social care without loss of effectiveness.
PRACTICE IMPLICATIONS : Use of professional interpreters may address communication-related disparities for these women.
Practice involved the same sequence with either the same visual-spatial or motor coordinates on the two days.
Practice of a motor task decreases motor output variability in older adults and is associated with adaptations of discharge activity of single motor units.
Practice setting , younger age , and colocation with physicians were associated with EHR use.
Practice staff and pharmacists were generally positive about the DUE program.
Practice was scheduled over @number@ days involving either the same visual-spatial or the same motor coordinates.
Practising arts has been linked to lowering stress , anxiety and blood pressure.
PRACTITIONER MESSAGE : Mapping exercises are valid procedures to understand the extent to which a survey protocol covers the spectrum of functioning.
Practitioners and policy-makers should heed both the high use and lower prescribing quality of antidepressants , anxiolytics , and sedative-hypnotics in NH residents.
Practitioners can surmount these barriers by enacting communication strategies tailored to older adults.
Practitioners have near-total freedom of prescription and practice.
Practitioners may use these findings to help identify older adults with low muscle power capacities and possibly overall functional decline.
Practitioners must remain vigilant for potential drug interactions and intervene when there is a potential for harm.
Practitioners should be aware of these findings to avoid unnecessary referrals.
Practitioners should emphasize the importance of PA to their patients and take steps to monitor their patients ' involvement in PA.
Practitioners should give consideration to individual variability when attempting to maximize the benefits of resistance training.
Practitioners should target improving player education around sugar and fibre consumption.
Practitioners training the older adult may benefit from a low-cost , easy-to-administer field test of upper body power.
Pragmatic trials are increasingly employed in health services research , although not commonly in the nursing home setting to which they are well-suited.
Pramlintide administration improved performance in the novel object recognition task , a validated test of memory and cognition.
Pravastatin , FTI-277 , and antioxidants improved PI adverse effects in HCAECs.
Praying increases mattering indirectly only through divine control beliefs.
PRCs are present in the developing eye of all vertebrates and remain active in lower vertebrates throughout life.
Prdm13 expression also showed diurnal oscillation and was significantly upregulated in the DMH of long-lived BRASTO mice.
Preadipocytes show varying proinflammatory expression profiles among WAT depots.
Preadmission treatment with SSRIs was associated with unfavorable outcome , which may reflect the prognostic significance of prestroke depression.
Preadmission treatment with SSRIs was present in @percent@ ( n = 266 ) of patients.
Prealbumin serum level was higher on day @number@ ( p @number@ ) compared to standard group.
Pre-analytical and analytical variations were examined.
Pre-analytical variables included fasting status ( FS ) and sampling timing.
Pre-analytic and analytic variables for TPMT genotype and phenotype ( enzyme activity ) testing were reviewed.
Pre and @number@ minutes post ingestion , participants also completed measures of readiness to invest physical ( RTIPE ) and mental ( RTIME ) effort.
Pre- and postintervention scores were compared to evaluate the effects of the intervention.
Pre- and post-intervention testing was carried out to assess sleep quality , fatigue , functional mobility and gait performance in these participants.
Pre- and post-operative adequate management can help facilitate a safer operation.
Pre- and postoperative pictures were compared using MERZ Aesthetic Scales.
Prebiotics have the ability to favour growth of beneficial bacteria , especially short-chain fatty-acids ( SCFA ) producers.
Pre-breathing oxygen in water may also preserve calcium homeostasis , suggesting a protective role in the physiological lymphocyte cell functions.
Preceding the instantaneous removal of the bar with a flash at one end resulted in a motion percept away from the flash.
PreCI is a good predictor of subsequent POCD and cognitive decline.
Precipitates of stimulated whole saliva were used for the evaluation of MUC1 expression using real-time PCR.
Precipitation methods for total tannin levels have also been identified as preferred protocols for these types of compounds.
Precipitation of proteins results in lens opacification , or cataract , the major blinding disease.
Precise diagnosis and adequate treatment are necessary to prevent cerebrovascular and ischemic heart diseases.
Precise reversions of the mutation lead to the restoration of the lifespan specific to control females.
Precision of the trunk rotation tests was lower than that of trunk flexion or extension.
Preclinical Alzheimer's disease ( pAD ) reflects neuropathological findings of AD in cognitively normal subjects.
Pre-clinical and clinical research indicate that ovarian hormones may play a major role.
Preclinical data will be reviewed and summarized , and available clinical data with riociguat and vericiguat , novel direct sGC stimulators , will be presented.
Preclinical models of these dysmetabolic settings have provided insights into the pathobiology of arterial calcification.
Preclinical studies have demonstrated that laser pretreatment at low energies enhances absorption of topical lidocaine.
Pre-clinical studies have identified a number of potentially efficacious neuroprotective agents ; however , nothing has been effectively translated into therapy in clinical practice.
Preclinical studies identified the perimenopause to menopause transition , a neuroendocrine transition state unique to the female , as a sex-specific risk factor for AD.
Preclinical studies showed that lithium treatment increased mtDNA content , but no study has directly assessed mtDNA content in subjects with BD in vivo.
Preclinical studies support a role for microRNAs in the posttranscriptional regulation of these transporters ; however , no evidence is still available on human atherosclerosis.
Pre-delirium scores from past cognitive tests and best scores were imputed after admission.
Prediabetes and metabolic syndrome are also related to an increased risk of developing and die from cancer.
Prediabetes was defined as impaired fasting glucose , impaired glucose tolerance and / or HbA1c @number@.7-6.4%.
Prediabetes was diagnosed in patients with impaired fasting glucose ( IFG ) , IGT or with HbA1c from @number@ to @percent@.
Predictable socioeconomic factors could be used to calculate and predict the rates for other well-established surgeries.
Predicted annual PV change rate differed depending on age , BMI , serum PSA level and baseline PV.
Predicted cognitive scores using our regression algorithm based on the resulting brain regions correlated well with actual performance.
Predicted convergent and discriminant validity patterns of the FMRI Symbol Search task were also observed.
Predicted cross-sectional estimates of change in hearing sensitivity reliably approximated longitudinal trajectories , with slight misestimations in the 8th decade.
Predicted probabilities and average annual percent change in probabilities are reported.
Predicted probabilities of follow-up colonoscopy by screening result and physician group were calculated.
Predicting cancer incidence can help to anticipate future resource needs , evaluate primary prevention strategies , and inform research.
Predicting prognosis after treatment can benefit further strategies of management , but currently there is no convenient predictor.
Predicting recovery following muscle injury can be difficult because it involves consideration of multiple factors.
Predicting the behavior of an underactuated object with nonlinear fluid dynamics based on an internal model appears daunting.
Predicting the reproductive lifespan of an individual woman remains an elusive , yet clinically important , goal.
Prediction accuracy has improved substantially over the last @number@ years due to improved methodology and a better understanding of features.
Prediction equations for RSMI and FAT% from sex , BMI , and handgrip strength values were developed using multiple regression analysis.
Prediction errors for aad estimates for individual observations were in the range of ±18 years at a @percent@ confidence interval.
Prediction models for serum 25 ( OH ) D concentrations < 50 and < 30 nmol / L were developed by using backward logistic regression.
Prediction of olfactory improvement in patients with chronic rhinosinusitis ( CRS ) is difficult with variable results from different studies.
Prediction of outcomes for the elderly is complicated by preinjury physical fitness and comorbid illness.
Prediction of the chronological age based on age-dependent changes in the DNAm of specific CpG sites within the genome is one such potential application.
Prediction results based on other people's labeled dictionaries of activity performed almost as well as those obtained using their own labeled dictionaries.
Predictions were tested in @number@ individuals age @number@ or older presenting for help with worry.
Predictive accuracy of a cognitive battery might be optimized by selecting both memory and nonmemory measures.
Predictive capacity of various cardiac imaging modalities was also discrepant.
Predictive capacity was evaluated through sensitivity , specificity , and predictive values.
Predictive factors are the same and must be assessed with the same attention reserved to younger women.
Predictive fornix volume reductions might be explained at least in part by clinically silent hippocampus degeneration.
Predictive models could offer new insights into body composition analysis.
Predictive probabilities can be used to identify those most at risk and in need of particular services.
Predictive probabilities were obtained across a range of performance levels.
Predictive validity for clinical outcomes ( length of stay , postoperative complications , discharge disposition ) was compared.
Predictive variables were age , sex , cognitive diagnosis , dementia etiology and severity.
PREDICTOR : Baseline creatinine clearance ( Clcr ) based on 24-hour urine collection.
PREDICTOR : DCE-MRI kidney segmentation data.
PREDICTOR : eGFR , INR as time-dependent covariate , and their interaction in the pharmacogenetics cohort ; eGFR in the reversal cohort.
PREDICTOR : eGFR ≥ @number@ 45-59 , and < 45 mL / min / 1.73 m ( @number@ ) .
Predictor factors for sustained response were accessed by receiver operating characteristic curve.
PREDICTORS : eGFR ( CKD-EPI creatinine equation ) , spot UACR.
PREDICTOR : Serum phosphorus levels were determined in @number@ FAVORIT trial participants at randomization.
Predictors included GDS total score , age , gender , premorbid intelligence , a binary amyloid variable and its interaction with GDS.
Predictors included leg speed , leg strength , leg strength symmetry , range of motion , balance , and kyphosis.
Predictors included structural factors , including needs and resources and dyadic characteristics , and psychological factors , including family obligation and investment in the relationship.
Predictors of 2-year mortality for both ethnic groups included older age , male gender , and ADL disability.
Predictors of AHR were then determined.
Predictors of an increase in morbidity and mortality would therefore provide a useful framework for the assessment and management of this demographic.
Predictors of a positive tilt test were prodromal symptoms and typical situational syncope.
Predictors of clinical outcomes , defined as HCC , orthotopic liver transplantation ( OLT ) and mortality , were assessed by Cox regression analysis.
Predictors of CMV infection and CMV-IgG among the infected individuals were analyzed using logistic and linear regression analyses , respectively.
Predictors of ED remission were lower age , current employment , and absence of voiding LUTS , angina , diabetes , and dyslipidemia.
Predictors of HRQOL were identified by multiple linear regression analysis.
Predictors of participation were being a woman , being younger , having a higher educational level , and being employed.
Predictors of placement were identified with multivariable Cox proportional hazards models.
Predictors of recurrent ICH and vascular death were derived using a multivariable Cox regression model.
Predictors of regular dizziness at 10-year follow-up were history of dizziness and impaired function of lower extremities.
Predictors of renal recovery were identified by Cox regression analysis.
Predictors of SMC in those with depressive symptoms included poor psychological well-being and hearing impairment.
Predictors of SMC may differ in those with versus without MCI and those with versus without depressive symptoms.
Predictors of turnover related to job burnout , negative social support , and region.
Predictors were measured at baseline.
Predictor variables are socio-demographics , health factors , acculturation , knowledge , financial concerns for medical care costs , and medical tourism.
PREDICTOR : Well-water arsenic and urinary total arsenic ( inorganic plus methylated arsenic species ) concentrations , adjusted for urinary creatinine concentration.
Predisposing conditions such as alcoholism , chronic viral hepatitis , aflatoxin B1 ingestion , and cirrhosis all contribute to the development of HCC.
Predisposing factors are generally not associated with the probability to use healthcare services after controlling for needs factors.
Predisposing factors for impairment of well-being are environmental concerns , anxieties , conditioning and attributions as well as a variety of diseases.
Predisposing factors for odor effects can be given by genetic and hormonal influences , imprinting , context and adaptation effects.
Predominant observation is an elevation of LDL cholesterol in all PCOS patients.
Predomination of various exogenous factors before and after accident was noted.
Preeclampsia ( PE ) is associated with future cardiovascular risk factors , and this premature vascular aging potentially modifies the ovarian aging process.
Pre-existing CD4 T cell responses were associated with more robust responses to influenza virus NP + M , but not H1 or H3.
Pre-existing dementia and depression were found in @number@ % of patients.
Pre-experimental measures were taken so that the average inter-stepping target distance could be adjusted for each belt speed based on each participant's self-selected gait characteristics.
Preference differences between those with a good and a poor appetite were analyzed using GLM adjusting for confounders.
Preference for smaller-immediate over larger-delayed rewards has been implicated in the basic neurobehavioral mechanisms of risk for addictive disorders and related externalizing psychopathology.
Preferences inform strategic choices by older persons given the context of available resources.
Preference was defined when ⩾70% of total alcohol consumed was either beer , wine or spirits.
Preferential exocytosis of newly synthesized insulin suggests that granule aging is a key factor influencing insulin secretion.
Preferential usage of specific variable region gene segments was not observed , although somatic mutations were documented.
Preferred colour of cup , gender and age of patient , number of sessions were recorded.
Preferred information sources included written information ( @percent@ ) , counseling ( @percent@ ) , and social networking websites ( @percent@ ) .
Preferred Reporting Items for Systematic Review and Meta-Analyses ( PRISMA ) @number@ item check list was used to help with reporting the findings.
PR efficacy was not different between the elderly group and the younger group by either parameter.
Prefrail / frail participants had significantly higher median VACS Index scores compared with nonfrail participants ( @number@ versus @number@ p < 0.001 ) .
Pre-frail or intermediate were those with one condition.
Prefrailty was defined by the presence of one or two criteria among the Fried criteria.
Pregabalin was shown to have a moderate to large effect ( @number@.695-3.805 ) on improving neuropathic pain post SCI in @number@ studies.
Pregnancy and vaginal delivery affect pelvic floor by increased intra-abdominal pressure , direct muscle trauma , nerve injury and connective tissue damage.
Pregnancy-associated plasma protein A ( PAPP-A ) is a biomarker routinely used in screening for Down syndrome in the first trimester of pregnancy.
Pregnancy is a dynamic process characterized by immune tolerance , angiogenesis , and hormonal regulation.
Pregnancy might be considered as parabiotic model of the interaction between two organisms of different age.
Pregnancy rate at time-lapse selected embryos reached @percent@ while embryos from standard cultivation only @percent@.
Pregnancy rates ( PR ) according to patient and septum characteristics ( septum size ) were the main outcome measures.
Pregnant women are susceptible to Plasmodium falciparum parasites that sequester in the placenta.
Prehabilitation must be integrated into the overall patient medical management , and must be associated with preoperative refeeding and postoperative rehabilitation protocols.
Pre imaging clinical hypotheses were probable DLB in @number@ possible DLB in @number@ and alternate diagnoses in @number@
Preimplant HINT / AZBio was compared with postimplant HINT / AZBio for each patient and between the two groups.
Preincubation ( @number@ h ) of MIN6 cells with 5HT or BW723C86 reduced GSIS and the effect of 5HT was prevented by SB204741.
Preincubation of normal fibroblasts with CS also protected against hydrogen peroxide-induced premature senescence.
Preincubation with BW723C86 increased PGC1α and PPARy mRNA and protein levels and decreased mitochondrial respiration and ATP content in MIN6 cells.
Pre-incubation with recombinant Klotho ( @number@ pM ) significantly prevented all of these alterations.
Preincubation with the antioxidant N-acetyl-l-cysteine ( NAC ) resulted in increased DMT1 at the apical membrane before and after addition of iron.
Pre- , intra- , and postoperative factors were compared by age groups.
Prelamin A accumulation causes nuclear abnormalities , impairs nuclear functions , and eventually promotes cellular senescence.
Preliminary analyses were conducted to examine the utility in distinguishing AD from non-AD neurological disease ( Parkinson's disease , PD ) .
Preliminary brain imaging studies show smaller brain volumes as well as white matter tract dysfunction in adults with hearing loss.
Preliminary clinical trials show that drinking hydrogen-dissolved water seems to improve the pathology of mitochondrial disorders.
Preliminary data suggest a higher toxicity and discontinuation rate , loss of efficacy , and impaired quality of life in frail patients.
Preliminary data suggests that ECHO-CT may improve the transitions of care processes between these sites.
Preliminary evidence supports a role of adequate analgesia in improving mood in people with dementia.
Preliminary findings of this novel intervention may have implications for other older adults with functional limitations.
Preliminary research also highlights the complexity of these disorders in older adults and the potential importance of medical morbidity as a risk factor.
Preliminary results from STRIDE , a clinical demonstration program of supervised walking for older adults admitted to the hospital with medical illness , are reported.
Preliminary results suggest that the SILLS has adequate concurrent and convergent validity.
Preliminary studies have demonstrated that school-aged children ( average age 9-10years ) show mimicry responses to happy and angry facial expressions.
Preliminary studies showed a detectable signal from at least @number@ probe sets present in all samples and replicates.
Preliminary studies show improvements in weight stabilization and appetite with short-term usage.
Preliminary studies show that pharmacological interventions in utero and dietary supplementation in early postnatal life may alleviate insulin resistance and reduce T2D risk.
Preliminary studies show that the platform generates CLSs that increase with the age of mice in an organ-dependent manner.
Pre-malignant tumor cells enter a state of irreversible cell cycle arrest termed senescence ( cellular senescence ; CS ) .
Premarital cohabitation has been found to be positively correlated with the likelihood of marital dissolution in the United States.
Premature aging could also be modeled in zebrafish embryos.
Premature aging disorders provide an opportunity to study the mechanisms that drive aging.
Premature aging , patterns of decline , risk- and resilience factors.
Premature aging syndromes are rare genetic disorders mimicking clinical and molecular features of aging.
Premature canities may occur alone as an autosomal dominant condition or in association with various autoimmune or premature aging syndromes.
Premature cellular senescence may act as a powerful tumor-suppressor mechanism in telomerase-deficient cells with mutations that cause T-SCE levels to rise.
Premature follicular luteinization appears to contribute to rapidly declining IVF pregnancy chances after age @number@ and can be avoided by earlier oocyte retrieval.
Premature graying is an important cause of low self-esteem , often interfering with socio-cultural adjustment.
Premature menopause is an amplified paradigm of the complex impact menopause can have on women's and couple's sexuality.
Premature ovarian failure ( POF ) is defined as lost ovarian functions before the age of @number@
Premature senescence acts when the cellular system is not able to adequately respond to noxious stimuli by synthesis of stressor molecules.
Premature senescence is an important event during diabetic nephropathy ( DN ) progression.
Premature skin aging in xeroderma pigmentosa ( XP ) is expected to show increased telomere attrition.
Premedical intervention before diseases is one of the principal practices in traditional Chinese medicine ( TCM ) for tackling health problems and diseases.
Premenopausal 30-35 year-old women ( n = 8 ) were used as young controls.
Premenstrual disorders vary in prevalence according to the definition or categorization.
Premorbid and current personality traits were assessed by proxies using the NEO Personality Inventory Revised.
Premorbid GCA is a risk / protective factor , but deficits after adjusting for early adult GCA suggest additional processes leading to declining trajectories.
Premorbid IQ and socioeconomic status have not been investigated as thoroughly and showed inconsistent results.
Premotor and / or early motor symptoms of ET could negatively influence self-perceptions of health status.
Prenatal neuroimaging requires reference models that reflect the normal spectrum of fetal brain development , and summarize observations from a representative sample of individuals.
PreOL degeneration is accompanied by early robust proliferation of OL progenitors that regenerate and augment the preOL pool available to generate myelinating OLs.
Pre-operative albumin level was significantly associated with survival ( hazard ratio @number@.957 : @percent@ CI ( @number@ @number@ ) ; p < 0.001 ) .
Preoperative and prolonged postoperative use of narcotic pain medication negatively affects sleep.
Preoperative anesthesia consultation is essential to examine the patient , evaluate the operative risk and plan preventive perioperative actions.
Preoperative cerebrovascular evaluation and adaptation of surgical strategies will provide preventative approaches for cerebral dysfunction after CABG.
Preoperative cognition and physical activity were not associated with postoperative changes in these domains.
Preoperative comorbidity status , graded according to the ACE-27 index , was a statistically significant predictor of flap recipient site complications.
PREOPERATIVE COUNSELING AND INFORMED CONSENT : The dermatologic consultation should include detailed assessment of the patient's skin condition and skin type.
Preoperative embolization is helpful in patients with S-M grade IV-V AVMs.
Preoperative embolization was performed in @number@ % in the surgical group.
Preoperative evaluation and understanding the patient's aesthetic expectations are essential for surgery planning.
Preoperative evaluation of elderly patients is an important component of surgical practice in the 21st century.
Preoperative examinations included barium esophagogram , direct laryngoscopy , ultrasonography , CT , MRI , and so on.
Preoperative falls occurred in @percent@.
Preoperatively , age was strongly linearly correlated with the green : blue ratio ( r = @number@ P < @number@ ) .
Preoperatively and at 12-month post-intervention , patient-reported outcomes were described using the FACE-Q questionnaire.
Preoperatively , postoperatively , @number@ and @number@ months , @number@ year and @number@ years after implantation , DEXA scans were performed around the femoral stem.
Preoperative microperimetry showed unstable eccentric fixation with a dense scotoma within the central @number@ degrees.
Preoperative MPOD was @number@ ± @number@ density unit ( DU ) .
Preoperative photography should be carried out in all cases of resurfacing.
Preoperative planning presupposes knowledge of available approaches and implant options , such as porous coated jumbo cups , modular augments , and cup-cage constructs.
Preoperative recognition of frailty may serve as a useful adjunct for risk assessment.
Preoperative risk assessment is focused on detailed review from anamnesis and physical examination together with the assessment of functional status.
Preoperative risks , outcomes , and costs were analyzed.
Preoperative serum calcium and PTH did not differ between groups , but older patients displayed higher postoperative serum calcium ( p = 0.01 ) .
Preoperative serum CA @number@ measurements did not identify patients in the older age group for whom surgery would be optimal.
Preoperative testing and eligibility considerations , intraoperative factors , and postoperative observation and follow-up will be discussed.
Preparations containing sodium phosphate are generally not recommended for the elderly because of increased renal complications.
PREPARE was rated a nine of ten ( ±1.9 ) for ease-of-use.
Preparing nursing students to meet the care needs of an expanding ageing population is a challenge for nursing education.
Preperitoneal fat tissue may be related to arterial stiffness.
Pre / postsurveys were completed.
Presarcopenia and sarcopenia precede age-associated physical disability.
Presarcopenia was defined as low ALM and sarcopenia as low ALM with low performance or low strength.
Presarcopenia was defined as low SMI only.
Pre-sarcopenic participants were not different from controls.
Presarcopenic women had higher ability to function in activities of daily living than sarcopenic women.
Presbyacusis refers to the physiological age-related changes of the peripheral and central auditory system leading to hearing impairment and difficulty understanding spoken language.
Presbycusis and presbystasis represent relevant problems of aging , caused by the increase in life expectancy in developed countries.
Presbycusis or age-related hearing loss ( ARHL ) affects most elderly people.
Presbyopia is a loss of accommodative amplitude and reduced ability to shift focus from far to near objects.
Presbyphonia is a physiological process of aging voice that includes morphological changes in the coverage mucosa , muscle , and cartilage.
Prescribed diet , fluids , oral hygiene status and allied health referrals were obtained by chart audit.
Prescribed psychotropic medication was more common among those newly bereaved , adjusted OR of @number@ ( @percent@ CI @number@.41-1.50 ) , compared to those married.
Prescribers should consider patients ' medication adherence when changing APD regimens to lower the costs of medical services.
Prescribing for older adults represents a significant challenge as the UK population ages.
Prescribing patterns were evaluated through a pharmacy database of medication orders.
Prescribing Permixon in combination with alpha-blockers can be demonstrated to provide benefits beyond use of either therapy alone.
Prescribing rates for oxygen , short-acting β2-agonists , and short-acting anticholinergics were @percent@ , @percent@ , and @percent@ , respectively.
Prescription dose was found to be the only significant predictor of local control on multivariate analysis.
Prescription drug adherence was determined by pill counts.
Prescription medication triggered the balance problem in @percent@.
Prescription of clinically significant anticholinergic medications ( ADS level @date@ ) @number@ days preceding the event date formed the primary exposure.
Prescription of medicines is a fundamental component of the care of older people , but evidence suggests that pharmacotherapy in this population is often inappropriate.
Prescription of potentially inappropriate medication ( PIM ) is one aspect of this concern that is considered to increase the risk of adverse health outcomes.
Prescription osteoporosis medication can reduce fractures , but many women do not accept treatment or discontinue treatment before benefits are achieved.
Prescriptions for testosterone are rising on a background of concern over potential adverse effects.
Prescriptions of anti-thrombotic medications and their association with the presence of atheromatous disease were evaluated by the mean of a logistic regression.
Preselected subgroup analyses of sex , race , age , and metformin were conducted.
Presence and abundance of this vector is associated with the risk for the occurrence and transmission of these diseases.
Presence and frequency were greater than in previous reports of primary care samples.
Presence of ≥2 pain-associated conditions was significantly associated with @number@ of the @number@ pain quality descriptors.
Presence of anxiety symptoms was defined as at least three distinct symptoms of anxiety.
Presence of cisterns correlated with higher VD grades ( P < @number@ ) .
Presence of DAo plaque was not associated with subsequent stroke or TIA.
Presence of disease led to a major decline in SA , levels of functioning and engagement in contrast remained relatively constant.
Presence of elevated depressive symptoms was defined as the 15-item Geriatric Depression Scale score ≥5.
Presence of frailty should also be taken into account in the definition of the cardiovascular risks in the older population.
Presence of GRIN did not alter significantly the magnitude or axis of the lens astigmatism.
Presence of high depressive symptoms was defined as a score of @number@ or greater on the 15-item Geriatric Depression Scale.
Presence of hyperthyroidism did not confer additional risk of ischemic stroke compared with nonhyperthyroid AF.
Presence of insomnia was inversely associated with physical fitness.
Presence of MetS was based on the harmonized criteria ( Alberti et al. , @number@ ) .
Presence of MPS did not predict conversion to AD after adjustment for age and time-interval.
Presence of multiple underlying comorbid diseases , rather than aging itself , is an important risk factor for IPUs.
Presence of OSA was defined by an AHI > 15.
Presence of performance inconsistency during repeated assessments of gait may reflect underlying subclinical disease , and help shed light on the earliest stages of disablement.
Presence of sarcopenia was determined according to the EWGSOP algorithm.
Presence or absence of biofilm was assessed by aerobic and anaerobic cultures.
Presenilin-1 ( PS-1 ) -mutated Alzheimer's Disease ( AD ) fibroblasts ( PSAF ) were used for studying the effects of PS-1 mutation.
Presenilin @number@ ( PS1 ) and presenilin @number@ ( PS2 ) are the catalytic subunit of γ-secretase , which cleaves APP and mediates Aβ production.
Presenilin @number@ ( PS1 ) mutations are responsible for many early-onset familial AD ( FAD ) cases.
Presenilin ( PS ) @number@ or @number@ is the catalytic component of the γ-secretase complex.
Presenilins play essential roles in memory formation , synaptic function , and neuronal survival.
Pre-seniors living in the community scored significantly higher than community dwelling seniors on prevalence , extent and severity of OHIP-14 scores.
Presentation time did not influence cognitive performance , and visual gradation did not differentially influence primary and secondary memory.
Presented here are current evidence-based studies regarding age-related changes in the facial skeleton and soft tissue envelope.
Presented results support the potential application of Zr-Si scaffolds for autologous bone tissue engineering.
Presenting and best-corrected VA was assessed using early treatment diabetic retinopathy study chart.
Presenting complaints as recorded by triage nurses have been recoded according to the Canadian Emergency Department Information System list version @number@
Presenting with a spectrum of clinical features , actinic keratoses are believed to be predictors and precursors of invasive squamous cell carcinoma.
Present in notable volume were fibroblasts , collagen fibers , elastin fibers , adipocytes , and neurovascular structures.
Presently , red blood cell units are stored up to @number@ days in France and Canada.
Presently , the drugs used in Alzheimer's disease are only effective symptomatically and improve functioning.
Presently , the preservation of seminal and testicular spermatozoa , embryos , and oocytes can be readily achieved with a high functional survival rate.
Presently there are no effective disease-modifying therapies.
Presently , there are no published studies on the mechanics of bone cement removal by a sawing process.
Presently , there is no causal therapy available to slow down or halt disease progression.
Presently , the term FTD encompasses clinical disorders that include changes in behavior , language , executive control , and often motor symptoms.
Presently this can only be explored through post mortem findings.
Present medical treatment included new-generation AEDs in @number@ ( @percent@ ) and both old- and new-generation AEDs in @number@ ( @percent@ ) patients.
Present observation suggests that significant number of individuals developed pigmentation and palmoplantar hyperkeratosis with black-brownish patch on their body and many of those developed carcinomas.
Present psychological and economic theories do not adequately account for the variations in patterns of wellbeing with age across different parts of the world.
Present results shed some light on neural underpinnings of AD and LLD and provide new useful evidence for differential diagnosis.
Present review focuses on the pharmacological aspects , cultivation methods and bioactive metabolites playing a significant role in various therapeutic applications.
Presents an obituary for James E.
Present study suggests intramuscular sex steroids to associate with strength and power regulation in female muscle providing novel insight to the field of muscle aging.
Presepsin concentrations were significantly increased in patients with kidney dysfunction.
Presepsin is elevated in patients developing infections and increases in a severity-dependent manner.
Presepsin plasmatic concentrations were measured on the PATHFAST point-of-care analyzer.
Preservation of an active lifestyle is considered an effective means through which everyday competence can be attained.
Preservation of fertility is a priority for many such women , and identification of women at risk of infertility is therefore important.
Preservation of functional ability is a well-recognized marker of longevity.
Preservation of RPP by pan-mTOR inhibitors was associated with inhibition of the pS6K / pS6 axis.
Preservation of the collagen matrix integrity by inhibition of endogenous dentin proteases is key to improving dentin bonding durability.
Preservation of the ovarian cortex containing a greater number of female germ cells is an experimental procedure under extensive investigation in many centers.
Preservation or recovery of the corticospinal tract is essential for good recovery of impaired motor function in patients with brain injury.
Preserved cognitive function in the context of age-related neuroanatomical and functional changes , has been attributed to compensatory mechanisms.
Preserved cognitive performance is a key feature of successful aging.
Preserving LLMS may be considered a very important determinant of functional independence in the elderly.
Preserving mitochondria and augmenting pinocytosis in cell-based therapeutics represent a new neurorestorative mechanism in BBB repair for stroke.
Preserving or restoring adequate nutritional status is a key factor to delay the onset of chronic diseases and to accelerate recovery from acute illnesses.
Preserving physical and cognitive functions is crucial to successful aging.
Preserving the integrity of proteins , biomolecules prone to molecular damage , is a fundamental function of all biological systems.
Pre-SMA activation correlated with frontal WMH load for ankle but not finger movements.
Prespecified subgroup analyses in patients with lower-risk and higher-risk prostate tumors were also carried out.
Pressure , segment width and length , azimuth and segment height allowed correct classification of @percent@ of the participants.
Pressure towards population aging in the demographic pyramid is not only due to sociological / personal choices but also due to subfertility or infertility.
Pressure ulcer prevention is an important long-term care ( LTC ) quality indicator.
Pressure ulcers ( PUs ) are injuries to the skin and underlying tissues , caused by sustained deformations and occur frequently in aged patients.
Presumably , patients are more concerned about chronic treatment effects.
Pre-surgical factors may substantially predict this outcome.
Pre-surgical factors were assessed preoperatively and divided into nine groupings of related factors ( \ "domains \ " ) .
Presymptomatic subjects showed significant decrease of REM sleep percentage , REMs density , total sleep time , and sleep efficiency.
Presynaptic nerve terminals release neurotransmitters repeatedly , often at high frequency , and in relative isolation from neuronal cell bodies.
Preterm birth is a significant public health concern.
Pretest and posttest assessments were performed after the theoretical-practical intervention.
Pre-test and post-test measures included life satisfaction , depressive symptoms , experiencing the environment as rewarding , and autobiographical memory ( AM ) scales.
Pretests and posttests were conducted immediately before and after the control and treatment periods.
Pretests and posttests were performed to evaluate gait speed of the participants before and after the study.
Pre-TIGR / post-TIGR data related to participant screening , recruitment , consent , and research processes were compared.
Pretransplant leukocyte telomere length in the recipients was not associated with posttransplant survival ( HR , @number@ @percent@ CI , @number@.64-1.30 ) .
Pretrauma FIM expression can be used to predict survival in the elderly trauma victim.
Pretreating fibroblasts with antioxidant abrogated the SSR-induced MMP-1 but has limited effect on heat-induced MMP-1.
Pretreatment and post-treatment evaluations were compared.
Pretreatment assessment was performed , and at @number@ and @number@ weeks after treatment.
Pretreatment baseline blood pressure ( BP ) and posttreatment BP on the 28th day were measured.
Pre-treatment is not necessary if the tested resin composite cements are used.
Pretreatment of bovine chondrocytes with AMPK activators AICAR and A-769662 inhibited both AMPKα dephosphorylation and catabolic responses after biomechanical injury.
Pretreatment of cells with a selective inhibitor of p38 MAPK reduced apoptosis and reversed the levels of HMGB1 release in response to HCT treatment.
Pre-treatment of HaCaT cells with apigenin and luteolin also inhibited UVA-induced production of the collagenases MMP-1.
Pretreatment of HepG2 and PANC-1 cells with MNF significantly abrogated the induction of ERK1 / 2 phosphorylation in response to AM251 and O-1602.
Pre-treatment of HS68 cells with GlcNAc inhibited UVB-induced production of the collagenases MMP-1 and MMP-13.
Pretreatment of IGF-1R ( + ) hCSCs with IGF-2 resulted in the formation of more mature myocytes and superior recovery of ventricular structure.
Pretreatment serum AMH , FSH , antral follicle count , and age predicted late ovarian activity by univariate analysis.
Pretreatments with MH , VL , and VP have minimally improved the tensile strength after aging.
Pretreatment with H2 suppressed H2O2-induced cell death , whereas post-treatment did not.
Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts.
Pretreatment with MAO-B selective inhibitor selegiline reversed the CSM-induced changes in MAO-B activity , ROS levels and IL-8 release in a dose-dependent manner.
Pretreatment with MH ( p = @number@ ) and VP ( p = @number@ ) presented higher initial TBS for CSA than for VAR.
Pretreatment with potent antioxidant N-acetylcysteine produced similar effect , suggesting enhanced antioxidant capacity induced by @number@ nm photomodulation.
Pretreatment with protease inhibitor PMSF has been shown to protect the aging of NTE and prevent the development of delayed symptoms in hens.
Prevaccination levels of serum retinol , α-tocopherol , and zinc as well as prevaccination and postvaccination HAI titer levels were measured.
Prevailing behavioral and structural senior malnutrition interventions have had marginal success , largely failing to reflect the realities of people's daily lives.
Prevailing concepts of ' active aging ' are introduced and their implications for the review of divergent gender differences are considered.
Prevailing subpopulation are macrophages , they are detected @number@ times more often than B-lymphocytes , and @number@ times more often than NK.
Prevalence and frailty risk were estimated by Poisson regression , while dependency and mortality risks and their predictors were determined using Cox regression.
Prevalence and incidence of dementia increase with demographic aging.
Prevalence and incidence studies often use unvalidated screening tools resulting in estimates of uncertain accuracy.
Prevalence and induction of mitochondrial autophagy is attenuated by senescence or doxorubicin treatment in vitro and in vivo.
Prevalence and prevalence odds ratios were estimated from a multivariable logistic regression analysis using appropriate sampling weights.
Prevalence , associated factors and clusters of multimorbidity have been studied in @number@ older adults ( ≥ @number@ years ) with ID.
Prevalence , characteristics and outcome of acute chest pain patients with causes other than AMI and elevated copeptin are poorly understood.
Prevalence data were calculated by pathology and by vertebral level.
Prevalence estimates reached @percent@ for chronic musculoskeletal pain in any location.
Prevalence estimates took into account the complex survey design and sampling weights.
Prevalence estimates were based on census data and previously published regional estimates.
Prevalence estimates were calculated and sex differences were tested with Pearson χ test.
Prevalence estimates were presented according to self-reported quality of life ( QOL ) .
Prevalence evaluated by gender is higher among younger women compared to older women and older men compared to younger men.
Prevalence including @percent@ confidential intervals were calculated and analyses were conducted for systemic and ocular associated factors with pseudophakia using multivariable logistic regression models.
Prevalence in @number@ - @number@ age group achieved the peak.
Prevalence is estimated to @percent@ in the 80-89 year-old patients , with a mean age of @number@ at the onset of heart failure.
Prevalence of advanced adenoma was also much lower among subjects who had previous colonoscopies ( SPR = @number@ @percent@ CI : @number@ @date@ ) .
Prevalence of ah lesions increased with time of biopsy after transplant ( TxBx ) .
Prevalence of AII from these studies was determined.
Prevalence of both metabolic syndrome ( MS ) and hyperuricemia are increasing.
Prevalence of cardiovascular ( CV ) disease is increasing worldwide.
Prevalence of chronic pain was @percent@.
Prevalence of clinical success was significantly higher in the SG than in the CG ( @number@ vs. @percent@ ; p = @number@ ) .
Prevalence of concurrent use by older adults varied widely between @number@ and @percent@.
Prevalence of CVD and CVD risk factors was assessed in a population of community-dwelling Ashkenazi Jewish adults aged @number@ to @number@ years.
Prevalence of dementing illnesses is expected to grow due to aging of the population throughout the world.
Prevalence of depression is between @percent@ and @percent@ in CVD patients.
Prevalence of drinking in excess of age- and sex-specific low-risk guidelines was high across all visits and did not vary according to disease burden.
Prevalence of dysmobility syndrome varied between studies ( 22%-34% in three of the studies ) .
Prevalence of each smoking cessation method use was calculated for each year , and its secular trend was tested by multivariate logistic regression.
Prevalence of food intolerance increased along with aging.
Prevalence of food intolerance in females ( @percent@ ) was higher than that in males ( @percent@ ) .
Prevalence of frailty tended to be higher among HIV-infected than uninfected controls ( @percent@ vs @percent@ p = 0.07 ) .
Prevalence of frailty was @number@ %.
Prevalence of frailty was @percent@.
Prevalence of frailty was @percent@ at baseline and @number@ % at both 2- and 5-year follow-up.
Prevalence of glucose intolerance progressively increases in age , and postprandial hyperglycemia is a common feature of glucose intolerance in the elderly.
Prevalence of HCV-co-infection was @percent@.
Prevalence of hyperuricemia increased from @percent@ in the 1st group to @percent@ in the 2nd and @percent@ in the 3rd group.
Prevalence of individuals experiencing diabetes mellitus was significantly higher in the males with stenosis than control group.
Prevalence of malnutrition and risk for malnutrition were @percent@ and @number@ % , respectively.
Prevalence of M-C types changes with aging , i.e. decrease of weddellite and increase of whewellite and uric acid in both genders.
Prevalence of mild cognitive impairment is @percent@ and of dementia @percent@ in the sample.
Prevalence of MUI based on each definition was described and compared to treatment response.
Prevalence of multimorbidity among people with HIV increased with age.
Prevalence of multimorbidity in older persons ranges from @number@ to @percent@.
Prevalence of muscle depletion was higher in men than women ( @number@ vs. @percent@ , P < @number@ ) .
Prevalence of NWO was @percent@ and @percent@ in men and @percent@ and @percent@ in women using tertiles and cutoffs , respectively.
Prevalence of occasional or frequent near-falls was @percent@.
Prevalence of optimal cardiac health was < 2%.
Prevalence of overweight was @percent@.
Prevalence of palmar fibromatosis increased with increasing age.
Prevalence of PIM at the time of antimuscarinic initiation was determined.
Prevalence of polypharmacy of eight or more medications was @percent@.
Prevalence of potentially inappropriate use was similar in AL and LTC ( @number@ vs. @percent@ , p = @number@ ) .
Prevalence of raised WC was higher in women ( @percent@ ) than in men ( @percent@ ) .
Prevalence of sarcopenia and presarcopenia was @percent@ and @percent@ , respectively.
Prevalence of schistosomiasis in Saudi people was significantly higher than it was in non-Saudi or immigrant ones.
Prevalence of secondary MR increased with age , from @percent@ in 18-44years old to @percent@ in individuals ≥75.
Prevalence of stroke and myocardial infarction decreased across successive birth cohorts , whereas diabetes prevalence increased.
Prevalence of subjects with DT > 6 was higher in males than in females ( OR @number@ @percent@ CI , @number@ @date@ ) .
Prevalence of subjects with FT > 3 was higher in females than in males ( OR @number@ @percent@ CI , @number@ @date@ ) .
Prevalence of technology use differed by the type of disability and activity-limiting impairments.
Prevalence of the features suggestive of macular telangiectasia type @number@ was assessed.
Prevalence of vigorous and moderate intensity physical activity was @percent@ and @percent@ , respectively.
Prevalence of vitamin D insufficiency was ( @number@ % ) in males and ( @number@ % ) in females.
Prevalence of women and married seniors.
Prevalence of work after retirement was higher in people who lived in rural region and increased due to increase in household size.
Prevalence ORs for proteinuria ( protein excretion ≥ 200mg / g ) comparing quartiles of total urinary arsenic concentrations were estimated using logistic regression.
Prevalence peaked in women ages 70 74 years with an estimate of @percent@ and in men ages 80 84 years with an estimate of @percent@.
Prevalence peak of urolithiasis was observed between 50-60 years of age in both genders.
Prevalence rates by age and gender were calculated for the elderly Brazilian population.
Prevalence rates for anxiety were @percent@ and @percent@ , as measured on the RAID and CAS , respectively.
Prevalence rates for each outcome variable were calculated.
Prevalence rates were obtained from a health insurance database.
Prevalence ratios were similar after controlling for the perception of crime , physical activity , and main mode of transportation.
Prevalence rose with increasing age , from @percent@ in those aged 60-69 years to @percent@ in those aged @number@ or over.
Prevalences for each condition were reported as percentages and were also estimated separately by age group and gender.
Prevalence studies have overstated the association between thyroid dysfunction and Down syndrome.
Prevalence studies have produced estimates with very wide ranges , mainly due to methodological differences.
Prevalence varied widely across studies for each condition.
Prevalence was also calculated by age and gender categories for Modic changes.
Prevalence was described by sex and age group , and a multivariate analysis was performed to test the factors associated with this condition.
Prevalence was especially high for mental health conditions ( @percent@ ) , hypertension ( @percent@ ) and asthma ( @percent@ ) .
Prevalence was higher in females than males.
Prevalence was highest among Pacific peoples ( ranging from 39-83% ) followed by Māori ( 18-57% ) and then European ( 7-35% ) .
Prevalence was increasing for all the considered cancer sites with the exception of the cervix uteri.
Prevalence was standardized using local census data.
Prevalent cases tend to be less severely injured than incident cases , and less than @percent@ of prevalent cases reside in nursing homes.
Prevalent in certain countries of Africa and the Middle East , the practice continues among immigrants to industrialized countries.
Prevalent obesity was significantly associated with lower wealth in women but not in men.
Preventative measures for cataract are critical because the availability of cataract surgery in much of the world is insufficient.
Preventative methods based on patient education and adequate sun protection behavior are particularly important.
Preventative strategies to assist problem gambling seniors , along with recommendations for further research , are discussed.
Preventing deterioration in glucose metabolism in the elderly may help preserve brain structure and function.
Preventing DGF may be more effective for decreasing the risk of death specifically attributable to the disease.
Preventing early onset of obesity is a priority for improving the care and outcomes for patients with pediatric ALL.
Preventing fall-related injuries is becoming a priority as the world population ages.
Preventing falls should be a public health concern , given that relatively easy changes can reduce the risk of falls.
Preventing intraoperative hypoxemia and hypotension may reduce the occurrence of MACE in these high risk patients.
Preventing loneliness is important for health promotion.
Preventing old age frailty should be recognized as an important goal of obesity and CVD risk control.
Preventing or delaying disability is therefore an important objective , and identifying an effective intervention could improve the lives of many older people.
Preventing / reducing CVDRF burden may reduce excess AMI risk among HIV + people.
Preventing sarcopenia and preserving muscle strength are highly relevant in order to prevent functional impairment and physical disability.
Preventing sarcopenia will require identifying mitochondrial sources of dysfunction that are reversible.
Preventing suicide in older adults would therefore require holistic and comprehensive approaches.
Preventing the potential ramifications of a worldwide epidemic of chronic noncommunicable diseases in a sustainable manner requires coordinated , collaborative efforts.
Prevention and adequately timed treatment can lead to successful body mass regulation.
Prevention and early intervention programs targeted to certain age groups may be required.
Prevention and early intervention strategies must be formulated to reduce the risk of oral diseases in this population.
Prevention and intervention with this population should take into account gender differences and sexual minority-specific risk factors.
Prevention and permanent searching attitude of efficient political health answers are two essential pillars.
Prevention and treatment initiatives that target these potentially modifiable factors may help promote successful aging in this growing segment of the population.
Prevention and treatment of chronic pain may be of significant help in reaching the aim to increase the healthy lifespan.
Prevention and treatment of these complications may improve mortality rates after cardiac operations.
Prevention in this sense meant enhancing the body's ability to cope with the environmental hazards of an already toxic world.
Prevention is key to helping older patients avoid potentially devastating situations , such as falls , medication errors and urban hyperthermia.
Prevention is the holy grail of cancer elimination , but making this a reality will take a fundamental rethinking and deep understanding of premalignant biology.
Prevention is the only positive successful way to achieve any of these possibilities.
Prevention of aging is mainly obtained through appropriate health practices , modulated by the genetic causes of aging.
Prevention of delirium using nonpharmacologic approaches is documented to be effective , while pharmacologic prevention and treatment of delirium remains controversial.
Prevention of disabling foot pain in later life should be prioritized and predisposing factors identified as potential intervention targets.
Prevention of greater fatness in old age may decrease the loss of lean mass and maintain muscle quality and thereby reducing disability and mobility impairments.
Prevention of heart disease , exercise vigilance , may reduce MCI mortality and delayed MCI diagnosis in persons with higher education impacts mortality.
Prevention of Klotho decline and supplementation of Klotho can be a novel therapeutic strategy for many age-related diseases.
Prevention of Met S should be considered , and this may be of help to decrease the prevalence of PE.
Prevention of physical disability represents a major public health priority.
Prevention of problems associated with mental confusion rests in identifying comorbidities , their severity , and the risk factors associated with delirium syndrome.
Prevention of sarcopenia requires that protein receives more attention in dietary prescriptions.
Prevention of skin aging and its treatment is an emerging field for development of new formulations in cosmetics.
Prevention of such oxidative cellular damage by the aqueous extract of Phyllanthus amarus has been investigated in this study.
Prevention of these problems and their treatment are also discussed.
Prevention of visual loss is one of the keys to the maintenance of independence in older people.
Prevention or delay of this deterioration is considered crucial to maintain general health and increase longevity.
Prevention or reversal of age-related decrease in bone mass and increase in bone fragility has been based on inhibition of bone resorption using anticatabolic drugs.
Prevention should target on floating population , especially on females , those with lower education or at older age.
Prevention strategies are often developed from an understanding of disease pathobiology , but models of biological success may provide additional useful insights.
Preventive approach on risk factors such as reflux laryngitis , chronic medical condition , and vocal abuse should be considered in the management of presbylarynx.
Preventive catechin treatment reduced the impact of endogenous TXA₂ on the control of cerebral tone and maintained eNOS function.
Preventive measures excluding the intake of aspirin and nonsteroidal anti-inflammatory drugs before the meals can be recommended for food allergic and food sensitized adults.
Preventive measures targeting relevant TBI risk factors in these populations are warranted.
Previous aging and cueing studies suggest that automatic orienting driven by peripheral cues is preserved with aging ; however , inconsistencies can be found.
Previous and incident fractures also accounted for @number@ quality-adjusted life years lost during @number@
Previous and incident fractures also accounted for @number@ quality-adjusted life years lost during @number@
Previous and incident fractures also accounted for @number@ quality-adjusted life years ( QALYs ) lost during @number@
Previous animal studies have indicated associations between circadian clock genes and cognitive impairment .
Previous association studies might have been influenced by nuclear DNA and / or environment factors.
Previous associations were evaluated using a one-sided test based on the reported direction of effect.
Previous attempts at removing BMS have failed.
Previous attempts to relate brain structure and function to numerical competency have focused on behavioral measures from a single time point.
Previous binocular rivalry studies with younger adults have shown that emotional stimuli dominate perception over neutral stimuli.
Previous brain white matter voxel based morphometry ( VBM ) studies in ALS reported inconsistent results.
Previous cognitive telephone batteries have been limited in scope with a primary focus on dementia screening.
Previous cohort studies have consistently shown that indicators of SWB predict favorable life outcomes , including better mental and somatic health , and longevity.
Previous containerized data processing solutions were limited to single user environments and not compatible with most multi-tenant High Performance Computing systems.
Previous diffusion tensor imaging ( DTI ) studies confirmed the vulnerability of frontal callosal fibers to normal aging.
Previous electrophysiological studies revealed that human faces elicit an early visual event-related potential ( ERP ) within the occipito-temporal cortex , the N170 component.
Previous epidemiological studies have shown that methylglyoxal ( MGO ) levels are highly regulated in diabetic cardiovascular diseases.
Previous epidemiologic data demonstrate that cardiovascular ( CV ) morbidity and mortality may occur decades after ionizing radiation exposure.
Previous estimates of palliative care need focused primarily on specialist palliative care and included only a limited number of nonmalignant diseases.
Previous falls are the biggest risk factor for future falls , but few fall studies focus on the youngest-old.
Previous findings indicate age-related differences in frontal-amygdala connectivity during emotional processing.
Previous findings regarding β-carotene alone are not consistent.
Previous findings suggest that AGE and its receptor RAGE may be involved in the pathogenesis of autoimmune reactions through dendritic cell ( DC ) activation.
Previous findings suggest that older adults show impairments in the social perception of faces , including the perception of emotion and facial identity.
Previous genetic studies in the general population have identified multiple genes that are associated with AD.
Previous genome-wide association studies ( GWAS ) have identified @number@ HbA1c-associated genetic variants.
Previous genome-wide association studies ( GWASs ) have identified seven loci for plasma and erythrocyte palmitoleic and oleic acid levels in populations of European origin.
Previous head trauma was associated with higher bitter-salty and salty-bitter confusions relative to those of some other etiologies.
Previous heparin use and in-hospital bleeding are associated with worse prognosis.
Previous history of vascular disease ( prior TIA / stroke / PVD ) appears to be a significant associate of OH in this patient population.
Previous imaging studies have shown unique anatomic impacts within language networks in each variant.
Previous investigation revealed that age is a major risk factor for thomboembolic events.
Previous investigations have demonstrated a reduction in the number of epidermal LCs in elderly subjects.
Previous investigations in cutaneous biology have considered the effect of glycation on the dermal matrix molecules , involved in tissue stiffening during skin aging.
Previous iterations had all been administered by the professional actor / director / theatre professor who devised the program.
Previous literature has reported a wide range of anatomical correlates when participants are required to perform a visuomotor adaptation task.
Previous literature showed inconsistent findings of the effect of age on the variability of force and hence a systematic review was performed.
Previous literature suggests that age-related deficits of dual-task walking are particularly pronounced with second tasks that require continuous visual processing.
Previous literature supports an association between an increase in the rate of adverse events as the number of drugs taken by a patient increases.
Previously , age- and sex-based skull cortical thickness changes were difficult to evaluate based on the need for cadaveric skulls.
Previously , calcification was considered to be a passive process in response to metabolic diseases , vascular or valvular diseases , or even aging.
Previously described BM-MSC-specific miRNA fingerprints were also detected but these remained unchanged during expansion.
Previously described controversial findings associated longevity with specific mitochondrial DNA haplogroups ( hgs ) ( e.g. , J and U ) .
Previously diagnosed OLD was reported by @percent@ ( @percent@ CI @date@ @percent@ ) of the participants with spirometric obstructive pattern.
Previously , few studies have investigated the activation pattern of trunk muscles during walking.
Previously , however , a small proportion failed to lose at least @percent@ of their baseline weight.
Previously , it was recognized that many of the physiological changes that occur with spaceflight are similar to those seen with normal ageing.
Previously magnesium ions were shown to antagonize digitalis-induced toxicity , which is mediated by Na / K-ATPase inhibition.
Previously one of the major fluorophores of lipofuscin was identified as a bis-retinoid pyridinium salt called A2E , which is known to photochemically cause damage.
Previously , our group found an association between @number@ regulatory single nucleotide polymorphisms in the FYN gene with increased tau levels in the cerebrospinal fluid.
Previously placed synthetic mesh was removed in @number@ cases.
Previously , Reither et al.
Previously reported associations with cognitive decline have not been consistent.
Previously , such clinical findings were called \ "adverse cerebral effects of anesthesia on old people \ ".
Previously the atrophy of gastric mucosa that was the main cause for the decrease in acid secretion was understood as the phenomenon following aging.
Previously , the blockade of the MR has been shown to impair visuospatial and working memory in healthy young men.
Previously trained medical students carried out face-to-face interviews using a structured questionnaire with open- and closed-ended questions.
Previously unacceptable living or deceased kidneys are now successfully transplanted after being repaired with microsurgical techniques at bench.
Previously unavailable countrywide data on an Asian population will be acquired.
Previously unrecognised relationships with constipation and uncontrolled diabetes mellitus suggested the multi-faceted nature of cough in the elderly.
Previously validated self-report instruments were used to assess psychological factors.
Previously , we could show that miR-138 and @number@ are downregulated in CLL cells.
Previously , we defined a multi-marker modality that included cystatin C ( CysC ) , troponin T ( TnT ) , and age.
Previously , we developed a rice Aβ vaccine expressing Aβ , which reduced brain Aβ levels in the Tg2576 mouse model of familial AD.
Previously , we developed a robotic system for automatic ultrasound scan focusing on human's liver.
Previously , we established intermediate SSCs ( iSSCs ) undergoing the transition to mSSCs and generated gene expression profiles of SSCs , iSSCs and mSSCs.
Previously , we found prolonged development of some GABAergic proteins in human @date@ Pinto et al. , @number@ ) .
Previously , we have shown that AUF1 facilitates miRNA loading to Argonaute @number@ ( AGO2 ) , the catalytic component of the RNA-induced silencing complex.
Previously , we have shown that Cisd2 deficiency shortens lifespan resulting in premature aging in mice.
Previously , we identified LDLR isoforms that lacked exon @number@ or exons 11-12 and that are predicted to encode soluble , dominant negative , LDLR.
Previously we identified that palmitate can induce primary astrocytes to produce cytokines , causing AD-like changes in primary neurons.
Previously , we identified valosin-containing protein ( VCP ) as a mediator of ER stress-induced cell death.
Previously we observed that BRB inhibited mTOR / S6 signaling concurrently with reduction of the level of endogenous oxidants and constitutive DNA damage response.
Previously , we reported differential mRNA and microRNA ( miRNA ) expression between African American ( AA ) and white women with hypertension.
Previously , we reported that postreproductive-aged mice that received young ovaries displayed an increased life span.
Previously , we reported the successful use of a novel brain-computer interface ( BCI ) training system in improving symptoms of attention deficit hyperactivity disorder.
Previously , we showed that , compared to controls , the offspring of long-lived siblings had a better glucose tolerance.
Previously , we showed that experimental telomere shortening phenocopies reproductive aging in mice.
Previously we showed that expression of Asp421-cleaved tau in a neuronal cell model resulted in mitochondrial impairment.
Previously , we showed that the 8-isoprostaneF2α , ( 8ISO ) increases brain amyloid-β levels and deposition in the Tg2576 mice.
Previous mathematical models explaining glioma incidence are framed in a rather abstract way , and do not directly relate to empirical findings.
Previous methods of empirical mapping involve using regressions on patient or general population self-reported data from datasets involving two or more measures.
Previous myocardial infarction was equally registered in both groups.
Previous neuroimaging and behavioral studies demonstrated structural and functional changes in the motor system across childhood.
Previous neuroimaging and electrophysiological studies have demonstrated dysfunction in specific brain areas related to visuospatial attention.
Previous neuroimaging studies reveal that MCI is associated with aberrant sensory-perceptual processing in cortical brain regions subserving auditory and language function.
Previous neuroimaging studies showed that correct resolution of lexical ambiguity relies on the integrity of prefrontal and inferior parietal cortices.
Previous ocular surgery was exclusion criterion in all groups.
Previous pharmacological evidence suggested that up-regulation of endogenous heme oxygenase-1 ( HO-1 ) in astrocytes promotes transformation of normal mitochondria to CA-like inclusions.
Previous positron emission tomography ( PET ) studies based on small samples investigated if it is related to memory impairment.
Previous reports failed to find this connection because of the use of patient´s cells immortalized by TERT expression or recombined telomeres by ALT pathway.
Previous reports have demonstrated the beneficial effects of polyphenols for healthy skin.
Previous reports have shown global deficits in neuropsychological measures among males with FXTAS , particularly those related to executive functioning.
Previous reports have shown that eIF2α phosphorylation is induced upon treatment with HDACi.
Previous researches focuses on the phytochemistry , biological properties and clinical application of rhizomes and tubers of C. rotundus.
Previous research examining the impact of unilateral divorce law ( UDL ) on the prevalence of divorce has provided mixed results.
Previous research finds that the ability to borrow from a DC plan increases contemporaneous contributions , consistent with traditional models.
Previous research had suggested a link between higher levels of technology use and hearing aid success.
Previous research has demonstrated differences in pharyngeal size and constriction between normal younger and older adults.
Previous research has demonstrated that a large proportion of home care clients specifically identified as having rehabilitation potential do not receive it.
Previous research has found commonality in the pains of imprisonment reported by English and American long-term inmates.
Previous research has found that as a marker of childhood circumstances , height is correlated with cognitive functioning at older ages.
Previous research has found that epileptic spasms occur in a sleep / wake and diurnal rhythm.
Previous research has found that stroke increases suicide risk , especially among women and younger patients.
Previous research has found the employment consequences of poor health to be of increased magnitude in low qualified groups.
Previous research has identified the age prospective memory paradox of age-related declines in laboratory settings in contrast to age benefits in naturalistic settings.
Previous research has not examined how assessments of avoidable readmissions differ between hospital and SNF perspectives.
Previous research has primarily focused on global measures of WMH burden and broad localizations that contain multiple white matter tracts.
Previous research has shown a wide array of age-related declines in vision.
Previous research has shown that an early onset of drinking is associated with a range of problematic drinking outcomes in adulthood.
Previous research has shown that as people transition to retirement they display heterogeneous growth in outcomes.
Previous research has shown that drivers aged over @number@ years can improve their scores in video-based hazard perception tests following training interventions.
Previous research has shown that most laypeople hold one of two typical conceptions of wisdom a cognitive or an integrative conception.
Previous research has shown the vast mental and physical health benefits associated with yoga.
Previous research has suggested that gardening activity could be an effective form of regular exercise for improving physical and psychological health in later life.
Previous research has suggested that infants may have more robust memory for past experiences relative to memory for locations that have been encountered previously.
Previous research has suggested that the age-related increase in oxidative DNA damage in T lymphocytes might contribute to their functional decline with age.
Previous research indicates that perception of audio-visual ( AV ) synchrony changes in adulthood.
Previous research in the United States suggests that depression related to economic hardship decreases with age.
Previous research on the physical health consequences of childhood abuse and other adversities has been based on data from young or middle-aged adults.
Previous research on V. cauliflora extracts suggests its potential to neutralize cellular oxidative damages related to the production of reactive oxygen and nitrogen species.
Previous research revealed typical reaction time ( RT ) profiles for procues and anticues as a function of PI.
Previous research shows that the correlation between income and life satisfaction is small to medium in size.
Previous research suggests that a high morale independently predicts increased survival among old people , though very old people have not been specifically studied.
Previous research suggests that high levels of negative emotions may affect health.
Previous research suggests that older adults suffer declines in producing accurate spellings but retain the ability to accurately detect misspellings.
Previous research suggests that the Tilburg Frailty Indicator ( TFI ) is a valid and reliable instrument for measuring frailty.
Previous stroke reduced the chance of improvement by @percent@ in frail men.
Previous studies about the effects of ageing on the episodic feeling-of-knowing ( FOK ) accuracy and its underlying processes have yielded conflicting results.
Previous studies addressing this question have tended to use complex behavioral tasks too broad to isolate specific neurocognitive processes affected by both alcohol and aging.
Previous studies also suggested that PGRN is involved in modulating lysosomal function.
Previous studies attribute these changes predominantly to the altered collagen and elastin organization and density of the extracellular matrix.
Previous studies demonstrated that testosterone could alleviate neurotoxicity induced by β-amyloid ( Aβ ) , but these findings mainly focused on neuronal apoptosis.
Previous studies demonstrate robust training effects but limited transfer in younger and particularly in older adults.
Previous studies examining the effects of cardiovascular drugs on muscle function have shown conflicting results.
Previous studies found that effortful encoding benefits episodic memory in older adults.
Previous studies from different fields have suggested creativity and capacity of WM have opposing characteristics possibly in terms of diffuse attention.
Previous studies had shown that processing speed and executive functions may be particularly reliant on the CC.
Previous studies have addressed age-related changes in skin colour.
Previous studies have associated telomere length with a number of age-related outcomes and it is hypothesized to be a quantitative indicator of aging.
Previous studies have been inconsistent with regard to identifying the association of androgens , namely total testosterone , with depressive symptoms.
Previous studies have been limited by incomplete ascertainment of baseline cognition or a lack of prospective delirium assessments.
Previous studies have demonstrated age-related changes in morphology and diffusion properties of brain tissue.
Previous studies have demonstrated a therapeutic benefit of pharmaceutical PGC-1α activation in cellular and murine model of disorders linked to mitochondrial dysfunction.
Previous studies have demonstrated beneficial effects of psychosocial resources on health outcomes in older adults.
Previous studies have demonstrated moderate to high test-retest reliability of DD , however , these studies utilized adult samples and examined relatively short retest intervals.
Previous studies have demonstrated that functional limitations increase , and organizational volunteering decreases , the risk of mortality in later life.
Previous studies have demonstrated that MG reacts with proteins and compositional modifications reflect loss of biological activity.
Previous studies have demonstrated that multiple modifications of blaNDM-1-harboring plasmids might contribute to the spread of the gene.
Previous studies have demonstrated the association between social exclusion and loneliness with mental health among the older population.
Previous studies have demonstrated transcranial direct current stimulation ( tDCS ) may improve language symptoms in patients with post stroke aphasia or neurodegenerative diseases.
Previous studies have described a potential link with ' vascular depression'.
Previous studies have either simply constructed the BA model by one or compared the four methods together.
Previous studies have examined the effects of mid-life physical activity on healthy ageing , but not the effects of taking up activity later in life.
Previous studies have found evidence for reduced cortical inhibition in aging visual cortex.
Previous studies have found that ligamentum flavum thickness ( LFT ) is correlated with aging , disc degeneration , and lumbar spinal stenosis.
Previous studies have found that poor dietary intake was common in elderly people living alone.
Previous studies have identified a number of factors that contribute to improved cognitive function , and to memory function specifically , in cognitively normal individuals.
Previous studies have identified both the focus of attention and the difficulty of a postural task as potential factors influencing dual-task performance.
Previous studies have identified five glabellar contraction patterns according to the predominance of eyebrow approximation , depression or elevation.
Previous studies have indicated that the main molecular characteristic of aging is the progressive accumulation of oxidative damages in cellular macromolecules.
Previous studies have mostly used univariate methods , and without considering potential anterior / posterior differences.
Previous studies have provided averages of radiographic indices for different age groups but not information about the rate of spontaneous correction and the affecting factors.
Previous studies have reported immunoglobulin-positive neurons in Alzheimer's disease ( AD ) brains , an observation indicative of blood-brain barrier ( BBB ) breakdown.
Previous studies have reported reliability and statistical power analyses in relatively small samples or only selected one aspect of brain anatomy.
Previous studies have reported that galangin has antioxidative activity against ROS-mediated stress.
Previous studies have reported the adverse cognitive effects of high folate status in older individuals with vitamin B12 ( VB12 ) deficiency.
Previous studies have reported the antitumor activity of MLN4924 mediated by its efficacy on apoptosis , autophagy and senescence.
Previous studies have revealed a loss of the ability to identify specific emotional facial expressions ( EFEs ) in old age.
Previous studies have revealed increased perceptual surround suppression of contrast in older adults.
Previous studies have shown an increased risk of physical and psychiatric illness.
Previous studies have shown increased false memory effects in older compared to younger adults.
Previous studies have shown significant association between elevated interleukin-6 ( IL-6 ) levels and frailty.
Previous studies have shown that Alzheimer's disease ( AD ) is associated with a reduced risk of cancer.
Previous studies have shown that a yellow filter ( CPF450 ) can increase contrast , motion sensitivity , vergence , and accommodation.
Previous studies have shown that balance training is effective in improving physical function and decreasing risk of falls.
Previous studies have shown that both young and older subjects adapt their reaches in response to a visuomotor distortion.
Previous studies have shown that clinical training is the most effective method of increasing students ' confidence in treating older patients.
Previous studies have shown that contextual cues improve memory performance and reduce interference in younger adults.
Previous studies have shown that declines in human fibroblast ATP levels interfere with programmed cell death and promote necrotic inflammation.
Previous studies have shown that depression is a precursor / prodrome or susceptible state for the development of dementia.
Previous studies have shown that extracts or products from human placenta significantly improve skin aging and chronic wound healing.
Previous studies have shown that hippocampal volume is an early marker for dementia.
Previous studies have shown that humans are sensitive to statistical patterns indicating the likely locations , identities , and timings of visual targets.
Previous studies have shown that LC-enhancing drugs can slow the progression of AD pathology , including amyloid aggregation , oxidative stress , and inflammation.
Previous studies have shown that mental health among older people who live with animals could be improved , but contrary results exist as well.
Previous studies have shown that more active older adults have better cognition and brain health based on a variety of structural neuroimaging measures.
Previous studies have shown that MRE11 is essential for the recruitment of RECQL5 to the DSB sites.
Previous studies have shown that non-optimal temperatures are associated with increased morbidity and mortality , specifically in elderly people.
Previous studies have shown that older subjects have difficulties discriminating the walking direction of point-light walkers.
Previous studies have suggested a link between sleep disordered breathing ( SDB ) and dementia risk.
Previous studies have suggested an association between PWS and comorbid psychiatric illness.
Previous studies have suggested a possible relationship between OS and frailty but this association remains unclear.
Previous studies have suggested psychosocial resources , including perceived control , may buffer this association.
Previous studies have suggested that better health care delivery models may preempt this decline.
Previous studies have suggested that excitotoxicity may contribute to neurodegeneration in these disorders , however the underlying mechanisms and their relationship to alpha-syn remain unclear.
Previous studies have suggested that parental criticism leads to more somatic symptoms in adolescent children.
Previous studies have suggested that the genetic factors predisposing to excess cardiovascular risk may be different in diabetic and nondiabetic individuals.
Previous studies have suggested the reaction of MG with free amino groups of proteins forming advanced glycation end products ( AGEs ) .
Previous studies in animal models have shown that deceased neuronal activity cause increased levels of Aβ inside neurons and cognitive decline.
Previous studies indicated associations between homocysteine levels and medication use , including antihypertensive , lipid-lowering and antidiabetic medication.
Previous studies indicated that a DNA repair system was involved in the development of rheumatoid arthritis ( RA ) .
Previous studies indicated that Because of its reconstructive nature , autobiographical memory ( AM ) is subject to a range of distortions.
Previous studies indicated that blind and visually impaired people are a group with greater risk of falls.
Previous studies in mice and humans suggested that GHRD has protective effects against age-related diseases , including cancer and diabetes.
Previous studies in older adults have identified that chronic low back pain ( CLBP ) is associated with slower gait speed.
Previous studies observed associations between early age at first birth ( AFB ) and all-cause mortality.
Previous studies of CDSMP have identified multiple resulting health benefits for participants as well as factors associated with participants ' completion rates.
Previous studies of diet and cataract risk have focused on specific nutrients or healthy eating indexes but not on identifiable dietary groups such as vegetarians.
Previous studies of human muscle architecture have focused on a single joint , two adjacent joints , or an entire limb.
Previous studies of ORF1p , purified from bacterial and insect cells demonstrated that this protein forms trimers in vitro.
Previous studies of response flexibility in healthy volunteers revealed frontal , temporal , and parietal cortex hyperactivation in children and hypoactivation in adults.
Previous studies of the ( COMT ) Val158Met genotype and cognition have focused on prefrontally guided executive functions involving dopamine.
Previous studies on colorectal cancer ( CRC ) yielded inconsistent results , but lacked information on covariates.
Previous studies on music have found autobiographical memories and life-long preferences for music from this period.
Previous studies on sustained attention ability in the elderly produced inconsistent results.
Previous studies on the safety of major liver resections in the elderly patients cite morbidity and mortality rates of approximately 30-40% and 4-5% respectively.
Previous studies primarily focused on inter-nodal connectivity of the DMN and often assume functional homogeneity within each DMN region.
Previous studies report conflicting results of the effects of DENV on Aedes aegypti survival.
Previous studies reported that arsenic exposure is associated with changes in plasma histone concentrations.
Previous studies reported that characteristic lens opacities were present in Alzheimer Disease ( AD ) patients postmortem.
Previous studies reported that in DLB patients functional alterations of the parieto-occipital regions were correlated with the presence of VH.
Previous studies reported that , with aging , cellular expression of IGFBP increases , while that of IGF-1R decreases.
Previous studies reported that WRN silencing in combination with deficiency in other genes led to significantly accelerated cellular proliferation and tumorigenesis.
Previous studies reported the association of increased SampEn with improved standing balance ability in young subjects.
Previous studies report inconsistent findings regarding the relationship between plasma CRP and Alzheimer's disease ( AD ) .
Previous studies revealed significant associations between OSAHS-related symptoms and obstructive airway diseases in the general population.
Previous studies showed that after klotho treatment , galectin-1 binds the TRPV5 N-glycan and thereby increases TRPV5 activity.
Previous studies showed that aged NK cells are less cytotoxic and exhibit impaired maturation compared to young NK cells.
Previous studies showed that longevity in the Uygurs was considerably greater than in Kazaks in Xinjiang.
Previous studies showed that NOTCH3 contains mutational hotspots that can vary among individuals of different ethnic backgrounds.
Previous studies showed the relationship between fatty acids and the risk of developing Alzheimer's disease ( AD ) .
Previous studies show that DTD could inhibit ICAM-1 expression induced by TNF-α.
Previous studies show that free radicals and reactive oxygen species play major roles in the etiology and / or progression of neurodegenerative diseases and aging.
Previous studies suggested lamins might bind actin.
Previous studies suggested that adequate medical staffing and appropriate care in the NH could reduce ED visits and hospital admissions.
Previous studies suggested that older adults are more likely to engage in heuristic decision-making than young adults.
Previous studies suggested that proteins conjugated to SUMO2 , but not to SUMO1 , could be regulated by the ubiquitin-mediated proteasome system.
Previous studies suggested that skin stimulation by using medical tape glued to the skin over the Achilles tendon can improve postural control in young adults.
Previous studies suggested that the performance of master runners ( > 40 years ) during marathon running has improved.
Previous studies suggest low vitamin K status is associated with higher osteoarthritis ( OA ) prevalence and incidence.
Previous studies suggest male sex hormones mediate effects on cardiovascular disease through myocardial repolarization.
Previous studies suggest that aging is associated with impairment of attention.
Previous studies suggest that Akt signaling promotes tissue regeneration and decreased Akt activities are found in aged tissues.
Previous studies suggest that being bilingual slows the decline in executive control associated with the aging process.
Previous studies suggest that it is generally associated with aging and chronic kidney diseases.
Previous studies suggest that men suffer from infectious diseases more frequently and with greater severity than women.
Previous studies suggest that OA is inversely related to OP when studied cross-sectionally and systematically.
Previous studies suggest that physical activity may be protective for dementia and cognitive impairment.
Previous studies suggest that processes involving the self and autobiographical memory are related to well-being , yet these relationships are poorly understood.
Previous studies suggest that reduction of apoE levels through genetic manipulation can reduce Aβ pathology.
Previous studies that have investigated the association between B-vitamin supplement use and risk for cataract yield conflicting results.
Previous studies that have measured reaction time and movement time have suggested that aging does not affect manual asymmetries.
Previous studies that reported a relationship between the presence of lobar microbleeds and decreased cognitive abilities have been primarily cross-sectional.
Previous studies within populations over the age of @number@ years have shown that response rates amongst older people can be @percent@ or less.
Previous studies yielded evidence for an interaction between age and valence in numerous cognitive processes.
Previous systematic reviews support the positive impact of various medication-related interventions but are not conclusive because of several factors.
Previous trials with NASHA dermal fillers have included small numbers of patients with pigmented skin.
Previous twin studies report no heritability of Parkinson's disease ( PD ) based on cross sectional information.
Previous women's health practitioners and researchers have postulated that some women are particularly sensitive to hormonal changes occurring during reproductive events.
Previous work demonstrated age-associated increases in the anterior P2 and age-related decreases in the anterior N2 in response to novel stimuli.
Previous work demonstrates that healthy adults decrease force output as a function of time when visual feedback is not available.
Previous work described the neuropsychological performance for English speakers.
Previous work examining biomarkers has focused almost exclusively on memory , although there is mounting evidence that attention also declines early in disease progression.
Previous work has confirmed evolutionary conservation of TASS elements while many cases show only low tissue specificity of isoform ratios.
Previous work has focused on muscle coordination during successful balance recoveries or the kinematics and kinetics of falls.
Previous work has shown a relationship between serum biomarkers of vascular risk and inflammation and NPS in AD.
Previous work , however , has suggested that the costs associated with engagement increase in later life and influence motivation.
PRFM provides autologous , natural , but concentrated platelet growth factor release and stimulation of surrounding tissue.
PRGF-Endoret-treated APP / PS1 mice also showed decreased astrocyte reactivity , and prevented protein synaptic loss.
Price elasticity was low.
Price-volume and risk-sharing agreements are also evolving.
Pridopidine , a postulated \ "dopamine stabilizer \ " , has been shown to improve motor symptoms in clinical trials of HD.
Primacy and recency performance were measured during learning and delayed recall.
Primacy performance during learning was associated with the right inferior and middle temporal gyrus as well as the right inferior parietal cortex and supramerginal gyrus.
Primary analysis was by intent to treat.
Primary and secondary endpoints were defined as hospitalization with ischemic stroke and intracranial hemorrhage in the first @number@ years.
Primary and secondary eye care systems should be strengthened to improve the care of blinding eye diseases in Qatar.
PRIMARY AND SECONDARY OUTCOME MEASURES : Eating arrangements , health condition and 24-hour dietary recall information were collected at baseline.
PRIMARY AND SECONDARY OUTCOME MEASURES : Sleep duration.
PRIMARY AND SECONDARY OUTCOME MEASURES : SRH is the outcome of interest.
Primary and secondary outcomes will be selected by KUs to ensure the results are relevant to their decision-making.
Primary and secondary prevention strategies have improved tremendously.
Primary barriers to participation related to staffing and perceived inability to recruit older adult participants meeting research criteria.
Primary care and hospital electronic records were reviewed for HTN diagnoses , antihypertensive treatment and blood pressure readings.
Primary care-based memory clinics are attracting increasing interest because they present an opportunity to improve dementia diagnosis and management.
Primary care clinicians play a pivotal role in the early recognition of cognitive impairment in their patients.
Primary caregivers of persons with dementia were assessed via in-person and telephone interviews every @number@ months over a 3-year period.
Primary caregivers provided data on nonsupportive parenting during a pretest when adolescents were age @number@
Primary care may play a role in negotiating a shared decision that is based on individual circumstances.
Primary care providers are expected to address the sexual health concerns of older adults.
Primary care reform can alleviate the pressures , but these initiatives require clinical benchmarks and evidence regarding utilization patterns.
Primary care settings present important opportunities for the detection and management of depression in older adults.
Primary care use and mortality were not significantly different.
Primary covariates included age , Charlson Comorbidity Index ( CCI ) , and a combined Charlson-age index.
Primary culture NSCs were treated with several concentrations of GV1001 and / or Aβ₂₅₋₃₅ oligomer for @number@ hours.
Primary cutaneous aspergillosis is most common in immunocompromised patients but can rarely be seen in healthy hosts as well.
Primary data was collected through structured questionnaire surveys in three cities in the region Nanjing , Ningbo , and Changzhou in @number@
Primary data were collected from stroke patients and their caregivers from @date@ to @date@ .
Primary ( degenerative ) and secondary ( functional ) mitral regurgitation ( MR ) is an important cause of heart failure.
Primary efficacy was rate of complete clearance of AK lesions.
PRIMARY ENDPOINT : High-sensitivity C-reactive protein.
Primary endpoints consisted of evaluation of bone turnover markers.
Primary end points were 30-day mortality and midterm survival.
Primary endpoints were maximal lower extremity strength measured by a leg-press device and duration of the 5-chair-stand test for functional performance.
Primary end-points were occurrence of cardiac events ( pacemaker implantation or tachyarrhythmia ) or death.
Primary findings were that fasting c-miRNA expression profiles were significantly predictive of aging , with miR-19b-3p , miR-206 , and miR-486 distinguishing between age groups.
Primary foci of atrophy were identified in the hippocampus and middle temporal gyrus ( MTG ) .
PRIMARY FUNDING SOURCE : Health Assessment Lab and National Institute on Aging.
PRIMARY FUNDING SOURCE : National Cancer Institute , National Institutes of Health.
Primary Funding Source : National Institute on Aging.
PRIMARY FUNDING SOURCE : National Institute on Aging.
Primary Funding Source : National Institute on Aging and National Heart , Lung , and Blood Institute.
PRIMARY FUNDING SOURCE : National Institutes of Health , BASF , Pfizer , and DSM Nutritional Products.
Primary HDFs were treated with biodynes , TRF , and tocopherol prior to hydrogen peroxide ( H2O2 ) exposure.
Primary healing of incisions were achieved in all cases.
Primary healthcare professionals should pay close attention to multigenerational families and invest in their education.
Primary health care services reimbursed for musculoskeletal disorders were used by @percent@ of women and @percent@ of men.
Primary hepatocytes and cholangiocytes were isolated and analyzed.
Primary lung cancer and Hodgkin lymphoma are two important non-AIDS-defining malignancies that are increasingly encountered at chest imaging.
Primary open angle glaucoma ( POAG ) is a degenerative disease commonly associated with aging and elevated intraocular pressure ( IOP ) .
Primary open-angle glaucoma ( POAG ) is characterized by progressive neurodegeneration of retinal ganglion cells ( RGCs ) .
Primary osteoporosis is usually a result of reduced bone mineral density as a consequence of natural aging.
Primary outcome is the frequency of fecal incontinence among patients.
Primary outcome measures included claudication onset time ( COT ) and peak walking time.
Primary outcome measures were clinical efficacy quantified by the Global Assessment Improvement Scale ( GAIS ) and a patient survey that assessed treatment satisfaction.
Primary outcome measures were factors associated with oxygen therapy and sustained oxygen therapy over the study period.
Primary outcome measures were mean arterial pressure ( MAP ) and symptoms.
Primary outcome measures were rates and severity of complications.
Primary outcome measures were wellbeing and proxy-measured pain.
PRIMARY OUTCOME MEASURE : Timed Up & Go ( TUG ) .
Primary outcome measure was cognitive function , and secondary outcome measures were psychological health variables and aerobic capacity.
Primary outcome measure will be the revised Neuropsychiatric Inventory - Clinician rating scale ( NPI-C ) to measure BPSD exhibited by the person with dementia.
Primary outcome occurred in @percent@ of women and @percent@ of men.
Primary outcome parameter is the cumulative number of AK lesions observed between visits @number@ and @number@
Primary outcomes are any hospital-associated geriatric syndrome ( delirium , functional decline , falls , pressure injuries , new incontinence ) and length of stay.
Primary outcomes are dietary change at @number@ months followed by weight loss at @number@ months that is maintained at @number@ months.
Primary outcomes are resting metabolic rate and core temperature , and are assessed at baseline and at 6-month intervals.
Primary outcomes from @number@ community-dwelling adults aged @number@ years and over were self-reported falls in the previous @number@ months and presence of @number@ chronic conditions.
Primary outcomes included length of stay , restraint use , discharge to rehabilitation , and hospital variable direct costs.
Primary outcomes of mobility , balance confidence , muscle power output and cross sectional area were analyzed using mixed effects modeling.
Primary outcomes were antilipemic use and low-density lipoprotein cholesterol control.
Primary outcomes were assessed by means of the Lubben social network and De Jong Gieveld loneliness scales , and by a revised social support questionnaire.
Primary outcomes were changes in self-reported clinical pain and objectively assessed pain sensitivity.
Primary outcomes were engagement in physical and cognitive activity.
Primary outcomes were global cognition and total brain volume.
Primary outcomes were IADL and BADL decline defined as an increase in the number of activities for which participants reported difficulty after @number@ years.
Primary outcomes were local recurrence ( LR ) and distance recurrence ( DR ) .
Primary outcomes were mental health-related well-being and mental health-related quality of life ( QOL ) .
Primary outcomes were overall postinjury complication and mortality rates , as well as death after major complication ( failure to rescue ) .
Primary outcomes were postoperative complications , mortality , hospital length of stay and readmission rates.
Primary outcomes were risk of falling and time until falls.
Primary outcomes were safety and tolerability.
Primary outcomes were the Fugl-Meyer Assessment and muscular properties ( muscle tone and stiffness ) .
Primary outcomes were weight loss and change in body composition ( bioimpedance measurements ) after the intervention periods and at follow-up.
Primary outcomes will include measures of SB ( time spent sedentary ) and PA ( counts per minute ) .
Primary outcome was activity limitations ( requiring assistance with mobility , self-care , and household activities ) .
Primary outcome was all-cause mortality.
Primary outcome was decline in functional activity ADLs assessed by the ADL Staircase @number@ months after discharge from hospital.
Primary outcome was deconvolution and approximate entropy analyses of pulsatile including basal and entropic modes of secretion performed at baseline and 3months.
Primary outcome was difference in mean test scores.
Primary outcome was effect of treatment on hypogonadal symptoms and quality of life as assessed by Aging Males ' Symptoms ( AMS ) scale.
Primary outcome was postoperative strabismus requiring palliation with prisms and / or strabismus surgery.
Primary outcome was the 30-day readmission rate between \ "users \ " and \ "nonusers \ " of LABDs±ICSs.
Primary ovarian insufficiency ( POI ) and polycystic ovarian syndrome are ovarian diseases causing infertility.
Primary percutaneous coronary interventions ( PPCIs ) improve outcomes in patients with ST-elevation myocardial infarction and facilitate the hospitalization course.
Primary photodermatoses are believed to be mainly irradiation-induced and immunologically mediated.
Primary POI comprises genetic aberrations linked to chromosome X ( monosomy , trisomy , translocation , deletion ) or to autosomal chromosome.
PRIMARY PRACTICE SETTING : Four medical units at one urban , university medical center.
Primary premature ovarian insufficiency ( PPOI ) is characterized by hypergonadotropic amenorrhea and hypoestrogenism in women under @number@ years of age.
Primary prevention measures should be strengthened to prevent falls , and reduce smoking and a sedentary lifestyle.
Primary preventive measures reduce stroke incidence and should be universally available and actively promoted at all levels of health care in South Africa.
Primary progressive aphasia is a neurodegenerative clinical syndrome that presents in adulthood with an isolated , progressive language disorder.
Primary reported barriers to mental health treatment included scheduling / availability , travel time and transportation , and discomfort with group settings.
Primary sarcopenia is considered to be age-related when no other cause is evident , other than ageing itself.
Primary stroke prevention is indicated in patients with silent brain infarcts , white matter hyperintensities , or microbleeds.
Primary stroke prevention studies in patients with diabetes reveal that tight control of glucose is not associated with reduction in stroke risk.
Primate and human studies have shown that early life stress increases the propensity for alcohol abuse in later life.
Prime-time animation is a television genre that frequently reflects on issues that are significant in contemporary society , including aging issues.
Primitive neuroectodermal features and MSC origin of ESFTs provide a basis of immune targeting.
Primitive reflexes were the most common ISNAs ( @percent@ ) , while dysphagia was the most rarely encountered ( @percent@ ) .
Princess VOLUME was well tolerated , and most adverse events were injection site reactions of mild to moderate severity.
Principal advisors for cocooning were pediatricians ( @percent@ ) followed by gynecologists / obstetricians ( @percent@ ) and general practitioners ( @percent@ ) .
Principal component analyses of GDS item scores revealed three factors ( the Dysphoria , Apathy-Anhedonia , and Anxiety-Concentration Factors ) .
Principal component analysis and linear discriminant analysis demonstrated the possibility of discriminating the samples in terms of aging time and raw material.
Principal-component analysis identified four cognitive factors.
Principal-component analysis identified four cognitive factors.
Principal component analysis illustrated the dominant concerted motions of G-quadruplex occurred at the loop domains.
Principal component analysis in young adults confirmed the modularity of attentional tasks , which was reduced in NA and AD participants.
Principal component analysis is used to transform complex and multivariate feature space to a smaller meaningful representation.
Principal component analysis ( PCA ) and discriminant analysis followed by biplot graph interpretation were applied to the gait parameters.
Principal Component Analysis ( PCA ) is a powerful method used to reduce redundant information and it allows the comparison of the complete waveform.
Principal Component Analysis ( PCA ) on @number@ gait variables was performed to determine underlying gait properties.
Principal component analysis ( PCA ) was used to determine if the inverse relationship between these components was due to their temporal and spatial overlap.
Principal component analysis ( PCA ) was used to identify three M-modes within the space of integrated indices of muscle activity.
Principal component analysis ( PCA ) was used to quantify the variance between the spectra.
Principal Component Analysis suggested that the outcome of CS is contingent upon the specific cultivar to which the CS technique is applied.
Principal component analysis was applied to each individual structural measure to generate eigenvectors.
Principal component analysis was then performed to study the factor structure of the EMQ in relation to the assessment.
Principal Component Analysis was used to characterize and statistically compare the patterns of knee joint movement and their relationships in walking.
Principal component analysis was used to construct a wealth index , and logistic regressions were performed to test the associations between wealth and elder abuse.
Principal component analysis was used to derive specific cognitive scores.
Principal component analysis was used to generate nutrient patterns ( NP ) from the full nutrient panel.
Principal component analysis was used to identify the SCI components.
Principal components analysis ( PCA ) of regional values of AChE activity and correlation analysis with neuropsychological test results was performed.
Principal components analysis , reliability analyses , and content validity were analyzed on the scale.
Principal components analysis resulted in five factors for the Likert version , accounting for @percent@ of the variance.
Principal components analysis yielded a 3-factor solution : LM-I and LM-D correct responses , LM-I and LM-D-unrelated errors , and LM-I / -D-related errors.
PRINCIPAL FINDINGS : A growing body of evidence suggests that general anesthetics may be neurotoxic to both young and aging brains.
PRINCIPAL FINDINGS : All health literacy measures were significantly correlated with all cognitive domains.
PRINCIPAL FINDINGS : The depressed group , as a whole , did not differ from the controls in telomere length.
PRINCIPAL FINDINGS : The spontaneous healing rate in the G1 control group was @percent@ , close to those observed in humans.
PRINCIPAL FINDINGS : We demonstrated that TNF-α induced cPLA2 mRNA and protein expression , promoter activity , and PGE2 secretion in HPAEpiCs.
PRINCIPAL RESULTS : Laboratory testing of influenza is incomplete.
PRINCIPLE FINDINGS : From @number@ to @number@ @number@ percent of Kenya's nursing workforce of @number@ nurses applied to out-migrate.
Principles and criteria of evaluation of degree of evidence the experimental studies in rodents as well as a possibility of extrapolation to humans are discussed.
PRINCIPLES : Given the demographic development , healthy aging becomes more and more relevant.
Prion diseases are a diverse group of neurodegenerative conditions , caused by the templated misfolding of prion protein.
Prion protein gene mutations have been associated with clinical pictures mimicking neurodegenerative diseases different from inherited prion diseases ( IPD ) .
Prions are infectious proteins that cause a group of fatal transmissible diseases in animals and humans.
Prior BLS training did not increase willingness to make an emergency call.
Prior experience may contribute to improved reactive behavior.
Prior factor analyses of this battery demonstrated a four-factor structure comprising memory , attention , language , and executive function.
Prior falls and depressive symptoms were associated with positive responses on both fall risk awareness questions.
Prior findings have also determined that interactions between antihypertensive medications and exercise may influence physical function above and beyond either factor alone.
Prioritized coding variants in SORL1 were detected by targeted resequencing and validated by genotyping in additional family members and unrelated healthy controls.
Prioritizing biogerontology is a requirement of well-ordered science.
Prioritizing patients and expediting transfer will decrease overall mortality , reduce hospital stay and reduce the cost of hip fracture care.
Priority areas for a future research agenda include strategies to improve clinicians ' ability to diagnose , prevent , and manage BBB abnormalities.
Priority for research was also assessed for each cluster.
Prior military service significantly attenuated the relationship between identity stigma and depressive symptomatology.
Prior MI or stroke predicted increased risk of subsequent events peaking after 10-20 years.
Prior modeling has primarily focused on quantifying the strain distribution in bone as an indicator of fracture risk.
Prior pressure ulceration with an odds ratio of @number@ ( @percent@ confidence interval , @number@.86-8.14 ) was the largest risk factor.
Prior projections appear to have underestimated the actual number of primary and revision THAs that are in demand.
Prior repeated stress induces expression of ethanol-induced social facilitation in adults and further enhances socially facilitating effects of ethanol among adolescent rats.
Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed , and working neuropathological diagnostic criteria are proposed.
Prior research adapted best practices in EOL care and aging ; but , delivery methods lacked emerging technology-focused learning and interactivity.
Prior research demonstrates that use of POLST alters medical treatments in a way that is consistent with the POLST orders.
Prior research has demonstrated age-related deficits in proactive control , including in conflict tasks.
Prior research has found that higher DHEA-S levels are protective against the physiologic damaging effects of stressor exposure and may reduce risks of illness.
Prior research on this reminiscence bump has focused on qualities of individual memories.
Prior research suggests that health literacy may influence knowledge , self-efficacy and self-care , but this has not been fully examined.
Prior research suggests that individuals with particular personality traits , like negative emotionality , are at greater risk for adverse health outcomes.
Prior research using data from married individuals has yielded inconsistent findings regarding the association between positive marital quality and global health outcomes.
Prior results suggesting that the overweight BMI category corresponds to the lowest risk of mortality may not be generalizable to indicators of health risk.
Prior studies also suggest enrichment of protein-bound 2-AAA as an oxidative post-translational modification of lysyl residues in tissues associated with degenerative diseases of aging.
Prior studies examining measures of cognition in relation to sleep have used either self-report or actigraphically measured sleep and have produced conflicting findings.
Prior studies found increased cortical volumes and decreased fractional anisotropy ( FA ) in SAD compared with healthy controls ( HCs ) .
Prior studies have not generated uniform findings on the associations between PF and EM.
Prior studies linking sleep and telomere length are mixed.
Prior studies show that sociodemographic factors influencing elderly's psychological well-being are multiple and differ across cultures.
Prior studies suggest that testosterone treatment may improve these functions.
Prior theories of the cause of diverticulosis suggested that constipation was an important cause , but new data challenge this and has provoked new ideas.
Prior therapies included cardiac-directed radiation ( @percent@ ) , anthracycline ( @percent@ ) , and alkylating ( @percent@ ) chemotherapies.
Prior to , and after , the 5-week study vertical countermovement jump ( VCMJ ) and range of motion ( ROM ) performance were measured.
Prior to , and following , LMA insertion , the position and depth of the vessels , and time to locate them were recorded.
Prior to and post training , choice stepping reaction time and stepping kinematics in untrained , diagonal and lateral directions were assessed.
Prior to any decision for pharmacological or surgical interventions , the underlying causes of UAB and detrusor impairment in each patient should be distinguished.
Prior to any intervention and after an evaluation of signs of severity , it is recommended to systematically assess the risk factors for falls.
Prior to auto-SCT , the calculated hematopoietic cell transplantation-specific co-morbidity index was also comparable.
Prior to blood collection , participants were asked to wear an uniaxial accelerometer for @number@ consecutive weeks to determine the physical activity status.
Prior to motion , the stimulus consisted of a static cloud of white dots on a black background.
Prior to new information , patients often have to be de-educated regarding common misbeliefs to undergo re-education.
Prior to respirometric analysis of mitochondrial function , mechanical and chemical preparatory techniques are utilized to permeabilize the sarcolemma of muscle fibers.
Prior to the MSLT last trial , they were asked to complete the Stanford Sleepiness Scale.
Prior to this field trial , the product Licatack was tested dermatologically to be skin safe receiving the grade \ "very good \ ".
Prior to use in therapy , extensive expansion is required.
Prior training and cognitive ability may impact practice and interval effects on real-world tasks.
Prior work has shown that both short and long sleep predict mortality.
PRISMA guidelines for reporting systematic reviews were followed.
Prison administration and policy-makers need to be more sensitive to gender and age related issues in order to remedy these vulnerabilities.
Prisoners themselves accurately self-report mental disorder , but the best way of detecting dementia in the prison population remains unclear.
Prison healthcare systems face increasingly complex organizational , budgetary and ethical challenges.
Private Residential Care Facilities ( RCFs ) fill the gap between independent community living and institutional settings for seniors.
PRKCD gene expression was also elevated in obese humans and was positively correlated with fasting glucose and circulating triglycerides.
PRL was available for @number@ men.
PRM was well tolerated , with an adverse event profile similar to that of placebo.
PRN medications were also examined.
PRNP gene analysis revealed methionine homozygosity at codon @number@ without mutation.
Proactive coping does seem to be an important variable in the psychological well-being of older adults.
Proanthocyanidins ( PA ) , the polymers of flavan-3-ols , have cardioprotective and cancer preventive properties as shown in clinical studies.
Probabilistic sampling was used to select @number@ elderly persons ( defined as > / = 60 years ) for the study.
Probabilistic sensitivity analysis revealed that the probability of accepting PR over IR exceeded @number@ % for all relevant ' willingness-to-pay ' thresholds.
Probability of an event was calculated using the Kaplan-Meier method , while contributing factors were assessed using univariate and multivariate ( Cox model ) analyses.
Probability of death increased exponentially as age increased.
Probable AD cases ( n = @number@ ) met published criteria and had appreciable amyloid deposits with PiB imaging.
Probable jaw osteonecrosis was estimated with an algorithm including diagnoses , surgical procedures , and imaging studies.
Probably there was capsular laxity because of aging , but we could not find any obvious reason responsible for this dislocation.
Probes that could discriminate between individuals are associated with immune and inflammatory functions.
Probing rRNA-coding regions of rDNA revealed no effects of aging on the rDNA content.
Probiotic biotherapies are known to create a healthy gut environment by balancing bacterial populations and promoting their favorable metabolic action.
Problem- and emotion-focused coping were associated positively with reasons for living and negatively with suicide ideation.
PROBLEM : Effects of HIV infection on ovarian function and aging are unclear.
PROBLEM : Ghana's population is ageing.
PROBLEM : Senior farmers have a @number@.6-fold risk of fatal injury compared to their younger counterparts.
Problems in the execution of this process are linked to different pathological conditions , such as neurodegeneration , aging , and cancer.
Problem-solving therapy , cognitive behavioral therapy , and treatment initiation and participation program have supportive evidence of efficacy , pending replication.
Problems with dentures that had been registered pre-treatment were improved at baseline but reoccurred after 1-5 years.
Problems with eating and appearance registered at pre-treatment were improved at baseline and after 1-5 years.
Problems with face recognition are frequent in older adults.
Problems with hearing ( @percent@ ) , vision ( @percent@ ) , and incontinence ( @percent@ ) were highly prevalent.
Problems with sexual functioning were relatively common , but overall levels of sexual health concerns were much lower.
PROBLEM : The rate of rehospitalizations from SNF within @number@ days of original discharge has increased within the last decade.
Procalcitonin and C-reactive protein levels were significantly higher in Gram-positive NHAP.
Procalcitonin and CURB-65 are accurate in predicting in-patient mortality in NHAP.
Procedural options for diminishing signs of intrinsic aging and cosmetic rejuvenation have expanded dramatically.
Procedural success was @percent@ ; no periprocedural complications were reported.
Procedure count was positively associated with all three hospitalization outcomes.
PROCEDURES : A qualitative description methodology was used to identify factors that influenced participants ' feelings about exercise and QoL.
PROCEDURES : Cats were evaluated to determine degree of radiographic DJD and signs of pain throughout the skeletal system.
Procedures for data access , information on collaborations , publications and other details can be found at [ @url@
Procedures have been implemented to safeguard the integrity of the data and the conclusions drawn.
Procedures include histochemistry , immunocytochemistry , and fluorescence microscopy.
Procedure time , radiation time , and complications did not differ.
PROCEDURE : We determined the growth patterns of patients with pediatric ALL during and after treatment through the conduct of a systematic review and meta-analysis.
Process-based cognitive trainings ( PCTs ) and novelty interventions are two traditional approaches aiming to prevent cognitive decline and dementia.
Processes of M1 related to strength or voluntary activation of biceps , but only in older adults.
Processes that regulate quiescence , self-renewal , and differentiation of hematopoietic stem cells ( HSCs ) are not well understood.
Processes that support genome integrity in normal cells , however , allow cancer cells to develop resistance to radiation and DNA-damaging chemotherapeutics.
Processes to recruit clinics and patients should be optimized.
Process evaluation will be also conducted.
Processing differences between monolinguals and bilinguals were identified for each task , although the locus differed across the tasks.
Processing multiple streams of spatial information is important for everyday tasks such as road crossing.
Processing of interleukin RNAs must be tightly controlled during the immune response.
Processing parameters such as core and sulfur concentrations were optimized at maximum luminescence efficiency during the shell preparation.
Processing relations and conjunctions of very elementary nonspatial features in STM led to dissociating performances in AE.
Processing speed was indexed using response times during those tasks.
Processing speed was measured using P300 latency and reaction time.
Processing western tonal music may yield distinct brain responses depending on the mode of the musical compositions.
Process measures including patient interviews , activity mapping and mealtime audits will inform interventions in each site and measure improvement progress.
Process of care was determined by the type of treatment and level of care received.
Process of family business succession may effect health.
Procoagulant activity was determined using annexin V ( prothrombinase activity ) and tissue factor ( TF ) assays.
Procoagulant processes culminate in thrombin generation and fibrin clot formation to protect the vasculature against uncontrolled bleeding after injury.
Procollagen type III N-terminal propeptide ( PIIINP ) and collagen type I carboxy-terminal telopeptide ( ICTP ) reflect collagen synthesis and degradation.
Producing and perceiving music engage a wide range of sensorimotor , cognitive , and emotional processes.
Product availability differs between these two aesthetic markets due to US Food and Drug Administration ( FDA ) regulatory requirements.
Production and isolation of forebrain interneuron progenitors are essential for understanding cortical development and developing cell-based therapies for developmental and neurodegenerative disorders.
Production costs and unit prices were analyzed.
Production of H2O2 was quantified and compared between the two groups.
Production of type I collagen declines is a main characteristic during photoaging , but the mechanism is still not fully understood.
Production of type I collagen was inhibited in UVA-irradiated fibroblasts , which was upregulated by CK.
Productions of non-native speech sounds were recorded and evaluated by native speakers.
Productivity perceptions are affected by one's age and one's position in the hierarchy.
Products were analyzed by a Sequenom® mass spectrometer , and classified as a mutation or wild type according to molecular weight.
Products were very well tolerated.
Products with immune protection factor contain DNA-repair enzymes and antioxidants that may reduce mutations and enable the immune system to combat photodamage.
Professional healthcare , besides family was seen as potential caregivers in old age.
Professional interviewers collected baseline data concerning socio-demographic characteristics , lifestyle habits , physical factors and geriatric assessment.
Professionals completed questions regarding program fidelity.
Professionals involved in cosmetic procedures should be aware of the risks.
Professionals involved in the care of kidney transplantation recipients must be better informed about the care , prevention , and early identification of auditory disorders.
Professionals mainly recognized the societal impacts of counteraction of aging , prevention of disease and social justice.
Professionals may benefit from considering the impact of cancer from a developmental life stage perspective.
Professor Denys Pellerin , one of the rapporteurs , stressed the problems this would pose in coming years.
Profiles or patterns of performance as pre-clinical phenotypes may be more useful than individual test scores or measures of global decline.
profile was previously registered.
Profiling of HrF offers a valuable new option in the management of person-centered health promotion.
Profound failure to thrive occurs during the 1st year.
Profound molecular changes occur in cells undergoing senescence.
Progenitor cell frequency was determined using a standard colony assay technique.
Progenitor-like glioma precursor cells show decreased asymmetric cell division rates and increased symmetric divisions , which suggests that asymmetric cell division suppresses brain tumor formation.
Progeria is a rare genetic disorder characterized by premature aging , involving the skin , bones , heart , and blood vessels.
Progeria is characterized by clinical features that mimic premature ageing.
Progerin , a C-terminal truncated lamin A mutant , causes premature aging termed Hutchinson-Gilford Progeria Syndrome ( HGPS ) .
Progerin activates expression of the Wnt inhibitors HES1 and TLE1.
Progerin expression affects tissues rich in cells that can be derived from marrow stromal cells ( MSCs.
Progerin only undergoes a subset of the normal post-translational modifications and remains permanently farnesylated.
Progerin , the pathogenic isoform expressed in HGPS tissues , has also been detected at low levels in tissues of normal individuals with aging.
Progerin was found to be significantly increased in the media of the dilated wall in tricuspidy , also showing increased periaortic inflammation.
Progesterone and its metabolites , in particular allopregnanolone , exert various effects on both cognitive and non-mnemonic functions in females.
Progesterone ( but not all synthetic progestins ) also has pivotal neuroactive functions in animal models of reproductive aging.
Progesterone was higher in females than males , but most other steroids were higher in males than females and almost all declined with advancing age.
Progestin levels are associated with eating during the luteal phase , but there does not appear to be a causal relationship.
Progestins may increase binge eating and eating stimulated by negative emotional states during the luteal phase.
Proglucagon-derived peptides , especially glucagon-like peptide-1 ( GLP-1 ) and its long-acting mimetics , have exhibited neuroprotective effects in animal models of stroke.
Prognosis in C4d ( + ) rejection is poorer than in C4d ( - ) rejection.
Prognosis is inversely correlated with patient's age , duration of disease and last GH level under treatment.
Prognosis of heart failure remains poor.
Prognosis of HHH syndrome is variable , ranging from a severe course with disabling manifestations to milder variants compatible with an almost normal life.
Prognosis strongly depends on stage at diagnosis , and the disease can be cured in most cases if diagnosed at an early stage.
PROGNOSIS : Two prognostic staging systems exist , the Rai and Binet staging systems , which are established by physical examination and blood counts.
Prognostic implications are significant , with key sex-specific inferences on physical function , frailty , disability , and pharmacodynamics that all merit further investigation.
Prognostic markers would be useful for clinical care and research.
Program characteristics , such as eligibility and consumer-directed options , are included.
Program coordinators worked with accounting staff to complete the questionnaires.
Program design includes monitoring sessions every other week to measure and record participant BP.
PROGRAM EVALUATION : Seventeen nurses successfully completed the exam , and @number@ faith community nurses participated in the program and completed the posttest.
Programmed aging refers to the idea that senescence in humans and other organisms is purposely caused by evolved biological mechanisms to obtain an evolutionary advantage.
Programmed cell death ( PCD ) pathways , including apoptosis and regulated necrosis , are required for normal cell turnover and tissue homeostasis.
Programmes are many and effective , and include extinction or extinction-based procedures , and scheduled awakenings.
Program @number@ was tested during the @date@ season.
Programs and policies that facilitate neighborhood support and commuting or promote facility accessibility may help ameliorate depressive symptoms common among low-income elders.
Programs involving senior volunteers assisting children , or children participating in activities with older people were considered.
Program sites included three Naturally Occurring Retirement Communities ( NORCs ) and one senior center.
Programs were more likely to include instruction on dementia than late-life depression.
Programs with clinical studies were subsequently classified as possessing Level I , II or III evidence.
Progranulin ( PGRN ) mutations have been recognized to be monogenic causes of frontotemporal lobar degeneration ( FTLD ) .
Progress has been hampered by gaps in our knowledge of the hair growth cycle's controls , to which hair pigmentation appears tightly coupled.
Progress in laser technology permits precise tissue removal and minimal thermal damage.
Progress in this area would be enhanced by improved in vitro alpha cell models and better tools for islet cell sorting.
Progress in understanding the cellular processes regulating gene expression networks in cognition is relevant to develop therapeutic interventions for age-related cognitive disorders.
Progression-free and overall survival were not significantly different in the @number@ groups.
Progression individually determined difficulty levels.
Progression of atherosclerotic lesions may gradually lead to plaque related complications and clinically manifest as acute vascular syndromes including acute myocardial or cerebral ischemia.
Progression of brain ageing is influenced by a complex interaction of genetic and environmental factors.
Progression of coronal and sagittal balance and pelvic obliquity with aging were not statistically significant.
( Progression of Early Subclinical Atherosclerosis [ PESA ] ; NCT01410318 ) .
Progression of periventricular WMH associates with noncardiovascular mortality , whereas progression of deep cortical WMH associates with cardiovascular mortality.
Progression of this vascular impairment may contribute to cognitive changes that arise with a similar time course during aging.
Progression or relapse will occur in all patients sooner or later.
Progression to bilateral any ( early and late ) or late AMD was assessed among participants with unilateral involvement only.
Progression to chronic gout has numerous causes such as poor compliance with , ineffectiveness of , or inability to tolerate prescribed regimens.
Progression to SILs was determined by comparing Pap test results.
Progression towards dementia was predicted only by low mood manifest in the prodromal stage of MCI.
Progression was detected in @number@ patients at @number@ @number@ and @number@ years after treatment , respectively , with progressive neurologic symptoms.
Progression was studied for cognition and activities of daily life ( ADLs ) , measured by MMSE and Katz Index respectively.
Progressive accumulation of Alzheimer's disease-related pathology is associated with cognitive dysfunction.
Progressive accumulation of deposits on outer segments was confirmed with scanning electron microscopy , revealing age-related changes in their morphology.
Progressive accumulation of lipofuscin within lysosomes indicates reduced lysosomal activity as a function of odontoblast aging.
Progressive and insidious cognitive decline that interferes with daily life is the defining characteristic of Alzheimer's disease ( AD ) .
Progressive cardiomyocyte hypertrophy , inflammation , and the gradual development of cardiac fibrosis are hallmarks of cardiac aging.
Progressive DNA damage and mitochondrial decline are both considered to be prime instigators of natural ageing.
Progressive loss of renal function causes a preferential loss of number and function of lymphoid cells.
Progressive loss of renal function is associated with a dysregulation of circulating T cells that may underlie their impaired T-cell immunity.
Progressive MS transitions to an accumulation of smoldering plaques characterized by microglial activation and slow expansion of pre-existing plaques.
Progressive multifocal leukoencephalopathy ( PML ) is still a underinvestigated central nervous system infection , often linked to HIV-related immunodeficiency.
Progressive muscle relaxation training , music intervention , and yoga had the strongest intervention effects on depression.
Progressive neurodegenerative diseases like Alzheimer's disease ( AD ) or Parkinson's disease ( PD ) are an increasing threat to human health worldwide.
Progressive neurovasculopathy in children with sickle cell disease ( SCD ) results in decreased cognitive function and quality of life ( QoL ) .
Progressive population aging has created many problems.
Progressive reactivation was observed after Flu-MPs inhibition using oxime 2-PAM.
Progressive resistance exercise should thus be encouraged among healthy adults to minimize degenerative muscular function associated with aging.
Progressive shortening of telomeres leads to senescence , apoptosis , or oncogenic transformation of somatic cells , affecting the health and lifespan of an individual.
Progressive skin darkening in response to repeated low-dose UV-A1 exposures in lightly pigmented individuals does not prevent UV-A1-induced collagenolytic changes.
Progressive supranuclear palsy is a rare parkinsonian disorder with characteristic neurofibrillary pathology consisting of hyperphosphorylated tau protein.
Progressive supranuclear palsy ( PSP ) is characterized by the deposition of tau proteins in some specific area such as the basal ganglia and brainstem.
Progressive synaptic dysfunction and loss closely correlate with cognitive deficits in AD.
Progressive telomere shortening from cell division ( replicative aging ) provides a barrier for human tumor progression.
Progressive visual processing decline is a known factor in aging.
Progress , the aging population and financial constraints would force policy-makers to steer the health system towards more centralized control.
Prog Retin Eye Res. @number@ 297-321. ; Hernandez , M.R. , Pena , J.D. , @number@
Prohepcidin levels of the elderly patients with anemia were positively correlated with biceps , subscapular and suprailiac skinfold thickness or body fat mass percentage.
Prohibitins are highly conserved proteins mainly implicated in the maintenance of mitochondrial function and architecture.
Pro-inflammatory and anti-inflammatory mediators derived from arachidonic acid ( AA ) modulate peripheral inflammation and its resolution.
Proinflammatory cytokines and heat shock proteins play relevant roles in the pathogenesis of inflammatory diseases.
Proinflammatory cytokines levels and hippocampal neuronal loss were evaluated after @number@ weeks of treatment in these NLRP1 or caspase-1 deficiency TLE rats.
Proinflammatory cytokines secreted from microglia are known to induce a secondary immune response in astrocytes leading to an inflammatory loop.
Pro-inflammatory S100A9 protein is increasingly recognized as an important contributor to inflammation-related neurodegeneration.
Proinflammatory T cells and monocytes persist after kidney transplantation , which constitutes a persistent cardiovascular risk factor.
Projected changes in NAFLD-related cirrhosis , advanced liver disease , and liver-related mortality were quantified through @number@
Projected increases in total hospitalisation days under different scenarios have highlighted that the contribution of ageing will become even more prominent after @number@
Project findings indicate that focused efforts to enrich training may increase intervention adherence.
Projections done for the time period used by the Congressional Budget Office in budget mark-ups ( 2010-2020 ) are presented in the supporting information.
Projections of the size of the increase assume the risk of AD is constant.
Project leads , champions , managers , and steering committees played vital roles in leading the spread process.
Project Recovery counselor data were collected through a 22-item qualitative interview.
Proliferation was evaluated by thymidine incorporation , and differentiation was evaluated by alkaline phosphatase , OPG , and PINP production.
Proliferative retinopathy is a leading cause of blindness , including retinopathy of prematurity ( ROP ) in children and diabetic retinopathy in adults.
Prolong bryostatin-1 treatment reduced apoptosis by decreasing caspase-8 and protected dermal fibroblasts.
Prolonged autophagy inhibition ( @number@ h ) failed to elevate ubiquitinated proteins in rat cortical neurons , although epoxomicin did.
Prolonged cardiac monitoring is recommended for patients with cryptogenic stroke.
Prolonged edema was the main complication and was considerably more frequent in the patients undergoing complete neck undermining.
Prolonged increase of intracellular calcium concentration is considered to be a significant trigger for neuronal apoptosis and cellular loss in JNCL.
Prolonged incubation with H ( @number@ ) O ( @number@ ) induced stress fiber formation , reduced Trx-1 protein levels , and increased apoptosis.
Prolonged latency and increased ECD moment of N13m might result from decreased peripheral conduction and increased cortical excitation system associated with aging.
Prolonged low dose treatment with hydrogen peroxide had no effects on cell proliferation or morphology.
Prolonged operative time and in any cases steep positions ( Trendelenburg ) have not represented a problem for the majority of patients.
Prolonged oxidative treatment had no effects on cell proliferation or morphology.
Prolonged p120 siRNA knockdown followed by withdrawal further expanded RPE into more compact monolayers with a normal phenotype and a higher density.
Prolonging life at the expense of its quality can rob elderly people of peaceful , meaningful years , Muriel Gillick tells Les Olson.
Prominent ductular reaction and increased numbers of IPC and IDS correlated significantly with older age and severe fibrosis / cirrhosis.
Prominent effects were found in prefrontal and association white matter compared with relatively preserved primary motor and visual areas.
Prominent frailty measures include the frailty phenotype and the frailty index.
Prominent increase in cortical porosity began at the fifth decade but reached a plateau before the sixth decade.
Prominent increase in Ct.Po began at the fifth decade but appeared to be arrested before the sixth decade.
Prominent intrinsic fall-risk factors are age-related decreases in balance and strength / power performance as well as cognitive decline.
Prominent superficial vasculature manifested as circumoral cyanosis and pronounced veins on the scalp and body.
Promising association signals were followed up in additional data sets ( of @number@ or @number@ T2D case and @number@ or @number@ control subjects ) .
Promising first results of a randomized trial have recently been published.
Promising future directions are lung regeneration with retinoids and stem cells.
Promising new drugs are Bruton tyrosine kinase inhibitors and other inhibitors of the phosphoinositide 3-kinase ( PI3K ) -mTOR-protein kinase B ( AKT ) pathway.
Promising preclinical studies demonstrated the lung protective effects of stem cell-based therapies in animal models mimicking BPD , leading to early-phase clinical trials.
Promising results are found regarding to the protection of proper brain circulation , structure and functionality in healthy and diseased humans and animal models.
Promoted awareness and better management of MSK might partly explain reduction in MSK mortality , but variations across countries warrant further investigations.
Promoter analysis revealed that NOX5-L expression is regulated by STAT5A in breast cancer cells.
Promoter DNA methylation , histone post-translational modifications , or microRNA expression are involved in the gene expression changes implicated in metabolic adaptation after exercise.
Promoter occupancy analyses revealed that FOXP1 directly represses transcription of p16INK4A.
Promoting and improving health demands adequate measures of health and the application of the Rawlsian veil of ignorance approach could be an effective alternative.
Promoting community involvement may be an effective strategy for healthy mental aging.
Promoting consumption of fiber-rich foods among the young may offer a means to prevent accelerated arterial stiffening in adulthood and related cardiovascular sequelae.
Promoting regular breaks might be useful in maintaining or increasing LEF and later life independence.
Promoting this population with controlled obesity and health improvement for renal function is important.
Promotion initiatives should target these periods to prevent the decline of PA.
Promotion of health approaching old age is important as few individuals transition away from their initial state.
Promotion of home medical care is absolutely necessary in Japan where is a rapidly aging society.
Promotion of the racemization of Asp residues in peptides with a neighboring Trp was much more significant than in those with Tyr.
Promotion programs should target these factors , reducing barriers to achieve desired changes in PAL.
Prompt diagnosis prevents frustration for the patient and allows treatment to be started at an earlier , more easily managed stage.
Pronounced differences were found between males and females in the glycosylation profiles of IgA enriched fractions.
Propagation of this instability is subject to influence by the microenvironment and will ultimately define cancer risk in the older population.
Propensity-matched analysis confirmed these findings.
Propensity-matched patients ( n = @number@ ) were well matched for age , gender , cognitive deficits , vision impairment , and dehydration.
Propensity score-adjusted Cox proportional hazards models assessed the 180-day mortality risk of each antipsychotic compared with risperidone.
Propensity score analysis controlled for the potential bias of combining participants from @number@ clinical trials.
Propensity score matching and sensitivity analysis were performed by limiting analysis to patients hospitalized for acute exacerbation of COPD ( AECOPD ) .
Propensity score matching methods were used to reduce observed differences between demented and non-demented groups at study enrollment.
Propensity scores were used to adjust for confounding by indication and logistic regression modeled the outcome and included all expected covariates.
Propensity scores were used to match participants with and without baseline depressive symptoms on multiple potential confounders.
Proper animal models are crucial for identifying the underlying mechanisms for brain AVM development and for testing new therapies.
Proper attachment of microtubules to kinetochores is essential for accurate chromosome segregation.
Proper brain function requires neuronal homeostasis over a range of environmental challenges.
Proper choice of model is critical for investigating cellular and molecular mechanisms of photodamage and photoaging.
Proper diagnosis allows correct treatment to prevent the occurrence of fragility fractures.
Proper glycosylation is essential for normal protein structure , function , and trafficking.
Proper health education and advice can be provided for this population.
Properly established treatment guidelines and prophylaxis for patients at risk are required as the high mortality rate continues to pose a future challenge.
Properly functioning skeletal muscle is critical for locomotion and performance of many activities of daily living.
Proper motor performance at 3rd month is necessary for further motor development.
Proper patient selection and education along with an experienced treating physician is crucial in achieving patient satisfaction and results.
Proper postoperative care is important in avoiding complications.
Proper regulation of mitochondrial functions represents a crucial element of overall metabolic homeostasis.
Proper technique and recognition of risk factors may reduce the incidence of this complication.
Proper thymic organization is essential to the optimal production of a functional T cell repertoire.
Prophylactic antibiotics and steroids or antihistamine drugs were adopted to reduce the risk of infection.
Prophylactic surgical extraction of impacted mandibular third molars , based on the assumption that surgical morbidity increases with age , may not be justifiable.
Prophylaxis with syngeneic regulatory dendritic cells ( DCreg ) in young bone marrow transplanted ( BMT ) mice has been shown to decrease GVHD-associated mortality.
Propidium iodide staining and scanning electron microscopy ( SEM ) verified cell death and morphological change of neutrophils treated by CTAB nanobubbles.
Propofol , in contrast to isoflurane anesthesia , significantly increased ( P < @number@ ) anti-inflammatory / antioxidant plasma γ-tocopherol concentration in patients.
Proponents of person-centred care , by contrast , suggest that such loss can be mitigated within environments that preserve rather than undermine personhood.
Proportional hazard models adjusted for age , sex , and education were used to examine the association between social activity and incident disability.
Proportional-hazard models evaluated the association of anthropometric indices with overall and cardiovascular mortality.
Proportional hazard models were used to estimate educational differences in all-cause mortality by HbA1c level with sequential adjustments for contributing risk factors.
Proportional hazards analysis was used to characterize survival by level of education.
Proportional odds regression analysis tested patient characteristics , PFD , and other determinants of sexual dysfunction as predictors of sexual function.
Proportional semantic and phonological access measures were calculated.
Proportion of myocytes of different ploidy classes did not change in the interval from @number@ to @number@ years.
Proportions of residents at risk of inadequate diets will also be determined.
Proportions testing was used to compare the Seattle Conference Q wave criteria with our data-driven criteria.
Proposals included the amyloid-β , cell cycle , cholinergic , inflammatory , oxidative stress , tau , and vascular hypotheses.
Proposed is a model of primary care for older adults with chronic health conditions that focuses on active engagement in health care.
Proposed markers were exposed to critique in a Workshop held in Newcastle , UK in @date@ .
Proposed pathogenic variants were confirmed by Sanger sequencing or array comparative genomic hybridization.
Proprotein convertases ( PCs ) represent highly selective serine proteases that activate their substrates upon proteolytic cleavage.
Prosocial behavior was measured by participants ' monetary offers to that opponent.
Prospective.
Prospective and experimental studies are needed to confirm these findings and determine whether improving microbiome health may buffer against sleep-related cognitive decline in older adults.
Prospective and intervention studies are needed to clarify the causal relationship between polypharmacy , comorbidities and fall risk.
Prospective and retrospective studies involving a control group were searched.
Prospective behavioral assessments were conducted annually over a three-year follow-up period to characterize onset of alcohol initiation , future drinking patterns and use disorders.
Prospective changes in bone and muscle mass will be investigated during the follow-up of our cohort.
Prospective cohort evaluation in @number@ patients.
Prospective cohort studies are needed to further elucidate endocrine disruptors as determinants of adiposity-related disturbances.
Prospective cohort studies are often conducted to study biological mechanisms and often collect longitudinal measurements on each participant.
Prospective cohort study.
Prospective controlled studies comparing the short- and long-term effects of different statins on cognitive function are warranted.
Prospective controlled trials are warranted to determine whether vitamin D supplements can increase longevity and reduce the incidence of certain conditions.
Prospective data were available for oldest old subjects only with a 4-year follow-up at @number@ years.
Prospective evaluation of liver steatosis remodeling after six years of follow-up.
Prospective larger trials should confirm this finding.
Prospectively , individuals high in Neuroticism perceived the event as a turning point ; extraverts learned a lesson from it.
Prospective memory difficulties adversely impact quality of life in community-dwelling older adults who experience problems independently managing their instrumental activities of daily living.
Prospective memory is a complex cognitive function requiring to remember a planned action.
Prospective memory performance follows an inverted U-shaped function across the lifespan.
Prospective memory ( PM ) tasks are those that must be performed in the future ( e.g. , attend an appointment ) .
Prospective population-based studies are needed to validate the prediction of Chinese FRAX® model and to establish ideal thresholds.
Prospective randomized studies targeting predictors , diagnostics , prevention , and treatment options for SBD are sorely needed.
Prospective remembering incurred dual-task costs for all three groups.
Prospective remembering is partially supported by cue-driven spontaneous retrieval processes.
Prospective studies are needed to address these challenges so that evidence-based guidance can be given to clinicians who treat older patients with hemophilia.
Prospective studies are needed to better characterize the clinical role of amyloid PET.
Prospective studies are needed to confirm these results to guide empirically based clinical treatment recommendations.
Prospective studies are needed to confirm whether this represents a survival advantage associated with lifetime low steady state temperature.
Prospective studies are needed to explore the use of the prognostic index as a mammography screening decision tool.
Prospective studies are needed to validate our result.
Prospective studies are required for verification.
Prospective studies of such screening are needed.
Prospective studies that establish the causal relationships between cancer and geriatric syndromes are necessary.
Prospective studies with extended follow-ups ( eg , @number@ years ) should examine whether bariatric surgery can attenuate cognitive decline in severely obese patients.
Prospective studies would be required to prove this aging effect.
Prospective time estimation was further correlated with mental time travel , as measured with the Remember / Know paradigm.
Prospects for developing new tracers for imaging other organ diseases also appear to be very promising.
PROSPERO Registration : 2014 : CRD42014007199.
PROSPERO REGISTRATION : PROSPERO registration number : CRD42015025961 .
Prostaglandin E2 ( PGE2 ) favors multiple aspects of tumor development and immune evasion.
Prostaglandin J₂ ( PGJ₂ ) family have been reported to show various kinds of biological activities.
Prostate and colorectal cancer survivors recruited from hospitals were randomized to OncoActive ( computer-tailored PA intervention ) or a usual-care control group.
Prostate cancer affects couples ' sexual intimacy , but men rarely use recommended proerectile aids.
Prostate cancer has the highest incidence rate among five common malignancies in Asian Americans.
Prostate cancer incidence is strongly related to age with the highest rates in older man.
Prostate cancer is a common malignancy among men , and the current screening , imaging and sampling approaches aim to detect early-stage , organ-confined disease.
Prostate cancer is a frequent cause of male death in the Western world.
Prostate cancer is a kind of commonly diagnosed male malignancy.
Prostate cancer is a major health burden within the ever-increasingly aging US population.
Prostate cancer is a serious oncological disease in males.
Prostate cancer is common in older men.
Prostate cancer is more common in men over the age of @number@ years.
Prostate cancer is the most common form of non-dermatological cancer among US men , with an increasing incidence due to the aging population.
Prostate cancer is the second leading cause of death among the U.S. men.
Prostate cancer ( PCa ) is a common illness for aging males.
Prostate cancer ( PCa ) is the most commonly diagnosed cancer and second leading cause of male cancer death in Western nations.
Prostate cancer ( PCa ) patients receiving the androgen ablation therapy ultimately develop recurrent castration-resistant prostate cancer ( CRPC ) within 1-3 years.
Prostate cancer-related exosomes were also isolated from the plasma of prostate cancer patients by anti-PSMA beads.
Prostate cancer will contribute with @number@ cases , colorectal cancer with @number@ and lung cancer with @number@
Prostate growth is ruled by testosterone.
Prostate ischemia resulted in epithelial atrophy , loss of smooth muscle , and diffuse fibrosis.
Prostate size had a minor impact on IPSS.
Prostate structure was examined by using Masson's trichrome staining and transmission electron microscopy ( TEM ) .
Prostate symptom scores improved in both groups.
Prostate volume and prostate-specific antigen increased moderately.
Prostatic development is a dynamic process in which basic mechanisms of epithelial outgrowth and epithelial-mesenchymal interaction are initiated by androgens and androgen receptor signaling.
Prosthetic arthroplasty has a historically poor record ; therefore , trapeziectomy remains the hallmark of current reconstructive techniques.
Prosthetic joint infection ( PJI ) is a serious complication of TJA that can significantly impact quality of life and physical function.
Proteases and their inhibitors have been recognized as key players in remodeling extracellular matrices and promoting the normal integrity of glandular tissue.
Proteases are a set of enzymes that have been involved in multiple biological processes throughout evolution.
Proteases that were released from isolated PMN cells degraded decorin in vitro.
Proteasomal removal of these proteins upon covalent polyubiquitination is highly regulated.
Proteasome impairment induces MGRN1 monoubiquitination , the key post-translational modification for its nuclear entry.
Proteasome-mediated degradation requires previous ubiquitylation of the cargo , which is then recognized by ubiquitin receptors directing it to 26S proteasomes.
Proteasome-mediated lifespan extension activity was carbon-source dependent and cells with enhancement proteasome function exhibited increased respiratory activity and oxidative stress response.
Proteasomes also regulate cellular processes through temporal and spatial degradation of signaling pathway components.
Protected area coverage of AZE sites is a key indicator of progress towards Target @number@ [ @number@ ] .
Protection from these ADP factors may be important for aging without significant ADP.
Protection was restored in almost all vaccinees after the second vaccination.
Protective effect of autophagy is associated mainly with removal of permeabilized mitochondria generating ROS , and elimination of abnormally folded proteins.
Protective effects were found for marital status and positive social relationships , yet these effects were more pronounced for men.
Protein aggregation disorders have been linked to molecular chaperones and to age related declines in molecular chaperones and co-chaperones.
Protein aggregation increases with age in normal tissues , and with pathology and age in Alzheimer's hippocampus and mouse cardiac muscle.
Protein and lipid oxidation-mainly by mitochondrial reactive oxygen species ( mtROS ) -was proposed as a crucial determinant of health and lifespan.
Protein and mRNA levels of various target molecules were analyzed by western blotting and quantitative RT-PCR , respectively.
Protein and mRNA levels of various target molecules were examined by Western blotting and quantitative real-time PCR , respectively.
Protein and mRNA levels were analyzed by Western blot and real-time reverse transcription PCR.
Protein candidates were selected into the signatures based on significance testing and a stepwise protein selection , each within 10-fold cross-validation.
Protein carbonyl accumulation is an indicator of oxidative damage to proteins during aging in cells and tissues.
Protein carbonylation is a major form of protein oxidation and is widely used as an indicator of oxidative stress.
Protein carbonyl levels were higher after exhaustive exercises than at rest.
Protein consumption was at the lower limit of the recommended intakes.
Protein content is a major determinant of skeletal muscle size.
Protein degradation plays a central role in many cellular functions.
Protein dishomeostasis , aberrant protein folding , and protein aggregation are indeed involved in several diseases including cancer , aging-associated , and neurodegenerative disorders.
Protein-energy homeostasis is a major determinant of healthy aging.
Protein energy malnutrition in the elderly causes preferential loss of muscle mass which is associated with poor functional states.
Protein expression analyses were performed by western blot.
Protein expression and phosphorylation were detected by Western blot.
Protein expression and phosphorylation were detected by Western blot or immunofluorescence.
Protein expression of Akt , p70 S6-kinase and Bcl-2 was markedly lower ( approx.
Protein expression of various cytokines was determined in muscle homogenates.
Protein expressions were examined in clinical samples and correlated with patient survival by log-rank Mantel-Cox test.
Protein expression was determined by Western blot analysis.
Protein expression was not age-dependent , and activities did not correlate to protein levels for either enzyme.
Protein function is generated and maintained by the proteostasis network ( PN ) ( Balch et al.
Protein glycation is a complex process that plays an important role in diabetes mellitus , aging , and the regulation of protein function in general.
Protein glycation is an irreversible , non-enzymatic , and relatively slow process.
Protein glycosylation is the most common epiproteomic modification involved in numerous physiological and pathological processes.
Protein homeostasis is critical for cell survival and functions during stress and is regulated at both RNA and protein levels.
Protein homoeostasis is a fundamental requirement for all living cells in order to survive in a dynamic surrounding.
Protein intake has been directly associated with kidney growth and function in animal and human observational studies.
Protein intake should be considered when evaluating the multi-factorial loss of physical function in older women.
Protein intake significantly increased during breakfast ( @number@ g ) and during the evening ( @number@ g ) .
Protein intake ( total , animal and plant ) was assessed as a continuous variable and by tertile of intake.
Protein intake was @number@ ± @number@ and @number@ ± @number@ g / kg body weight in male and female participants , respectively.
Protein is the most satiating of the macronutrients in young.
Protein level of β-actin and GAPDH was lower in older men compared with young men.
Protein levels of p53 , phosphorylated p53 ( Ser20 ) , and monoubiquitinated p53 were also measured , both in cytoplasm and nucleus.
Protein levels of Src in human breast cancer tissues correlated with accumulation of active YAP dephosphorylated on the LATS1 target site.
Protein levels were determined by western blot.
Protein levels were evaluated based on the immunohistochemistry of the skin of @number@ young and old individuals.
Protein misfolding can lead to chronic endoplasmic reticulum ( ER ) stress which can exacerbate oxidative stress.
Protein misfolding is linked to a rapidly expanding list of human diseases , ranging from neurodegenerative diseases to aging and cancer.
Protein molecular aging corresponds to all modifications affecting proteins during their biological life , which lead to the alteration of their structural and functional properties.
Protein N-glycosylation patterns are known to show vast genetic as well as physiological and pathological variation and represent a large pool of potential biomarkers.
Protein oxidation is typically associated with oxidative stress and aging and affects protein function in normal and pathological processes.
Protein oxidation was increased in hPHS-1 and @number@ cells exposed to DA or L-DOPA and further increased by AA addition.
Protein p53 is known to induce the cell cycle arrest and apoptosis in response to a variety of cellular distress signals and DNA damage.
Protein palmitoylation is known to promote protein dimerization.
Protein phosphorylation regulates a wide variety of cellular processes.
Protein prenylation is a ubiquitous covalent post-translational modification found in all eukaryotic cells , comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid.
Protein profiles of lenses that express wild-type ubiquitin ( WT-Ub ) or K6W-Ub differ by only ∼2%.
Protein quality control factors guard proteostasis and prevent protein misfolding.
Protein quality is a function of protein digestibility , amino acid content , and the resulting amino acid availability to support metabolic function.
Protein quality is important to the gain and maintenance of muscle mass.
Protein-rich supplements are used widely for the management of malnutrition in young and older people.
Proteins and amino acids are widely considered to be subcomponents in nutritional support.
Proteins and fats also have repair systems , but much simpler than those responsible for the repair of nucleic acids.
Proteins are important targets of several modifications caused by oxidative stress , leading to structural changes and consequently partial or total loss of their functions.
Proteins are main targets for oxidative damage that occurs during aging and in oxidative stress situations.
Proteins are one of the main molecular targets of age-related oxidative stress , which have been observed during aging process in cellular systems..
Proteins are one of the prime targets for oxidative damage and cysteine residues are particularly sensitive to reversible and irreversible oxidation.
Proteins are susceptible to numerous non-enzymatic post-translational modifications which occur both during normal aging and in neurodegenerative states.
Proteins from the RPE-choroid of eyes with thick and thin choroids were analyzed using two-dimensional electrophoresis and / or mass spectrometry.
Proteins , however , are excluded from topical applications due to their physicochemical properties.
Proteins identified in the BCE-ECM included ECM proteins , ECM-associated proteins , cell membrane proteins , and intracellular proteins.
Proteins involved in lipolysis were not affected by the intervention.
Proteins , lipids , and even whole organelles are engulfed in autophagosomes and delivered to the lysosome for elimination.
Proteins @number@ 85 : 1190-1211. © @number@ Wiley Periodicals , Inc.
Proteins prenylated by GGTase-II were not reduced in aged brain indicating a specific targeting of GGTase-I in the aged brain.
Proteins that tightly associate with cancer differentiation and progression , can bear important prognostic information.
Protein supplementation may exert an additive effect.
Proteins , widely studied as potential biomarkers , play important roles in numerous physiological functions and diseases.
Proteins with different abundances were identified by matrix-assisted laser desorption / ionization time-of-flight mass spectrometry.
Protein synthesis was inhibited concomitantly both with increased eEF2 phosphorylation and lower expression of tumor cell regulators , EGF receptors , cyclin A and MMP-9.
Protein translational machinery is an important component of the proteostasis network that maintains cellular proteostasis and regulates aging and other cellular processes.
Protein ubiquitylation is a key post-translational control mechanism contributing to different physiological processes , such as signal transduction and ageing.
Proteinuria increases ESRD risk , while the predictive role of other modifiable risk factors was unchanged compared with younger patients.
Proteinuria significantly increased the risk of ESRD with advancing age.
Protein variants with high pathogenicity scores were significantly rarer in the older branches of the tree.
Proteome-analyses of mitochondria from different organisms and organs revealed that more than @number@ proteins are localized in and / or on mitochondria.
Proteome-wide identification of both , transcription factors and coregulators , can profoundly improve understanding of mechanisms underlying genetic associations.
Proteomic analysis showed that eIF5B knockdown resulted in upregulation of @number@ proteins and downregulation of @number@ proteins compared with control cells.
Proteomic analysis , using MS , revealed that the most abundant posttranslational modification of aged lens proteins is racemization.
Proteomic and metabolomic profiling has the potential to help identify the underlying causal mechanisms that link genotype to phenotype.
Proteomic approaches are unequivocally powerful tools that may provide deeper understanding into the molecular mechanisms associated with cardiovascular disease and improve its management.
Proteomic changes responsible for the impaired successful pregnancy outcome after IVF with aged blastocysts have not been yet evaluated.
Proteomic data from an in vivo mice model in constant light and an in vitro oxidative stress model are compared to controls under normal conditions.
Proteomic identification of the increased TGF-ß1 provides supporting evidence for the role of podocyte apoptosis leading to human glomerulosclerosis.
Proteomic links the muscle functional changes with protein expression pattern.
Proteomics7 , 370-377 ] .
Proteomics9 , 523-537 ] .
Proteomics analyses have outlined the key role of band 3-ankyrin anchoring complex and the occurrence of selective RBC membrane remodelling mechanisms in microparticles formation.
Proteomics analysis revealed that @number@ proteins were differentially expressed in MG-treated SH-SY5Y cells , of which @number@ were upregulated and @number@ were downregulated.
Proteomics and metabolomics investigations of body fluids present several challenges for biomarker discovery of several diseases.
Proteomics approaches have been taken to study of human kidney tissue , serum / plasma , urine , and animal models of hypertension.
Proteomics assay of potential serum biomarkers of frailty in older adults.
Proteomics may have enabled the root cause of a major human-blinding condition , age-related cataract , to be established.
Proteostasis collapse can lead to the development of diseases known as proteinopathies.
Proteostasis depends on a network of molecular chaperones and clearance pathways involved in the recognition , refolding , and / or clearance of aberrant proteins.
Proteotoxicity resulting from accumulation of damaged / unwanted proteins contributes prominently to cellular aging and neurodegeneration.
Protocol date / version : @date@ / version @number@
Protocols for respirometry included titration of substrates for complex I ( glutamate ) , complex II ( succinate ) and both ( octanoyl-carnitine ) .
Protocols or algorithms to improve polypharmacy and prescribing in older adults have been developed.
Proton irradiation has also provided promising results for proton therapy in cancer due to targeting advantages.
Proton irradiation of tumors induces biological modulations including inhibition of angiogenic and immune factors critical to ' hallmark ' processes impacting tumor development.
Proton magnetic resonance spectroscopy was performed on formalin-fixed slices of human hearts at various circumferential locations ( N = @number@ ) .
Proton pump inhibitors ( PPIs ) are widely used to reduce gastric acid production , but information on the risk of dementia is lacking.
Prototypes were built and their hydrodynamic performances were tested on a cardiac pulse duplicator , in compliance with the ISO5840-3 : 2013 standard.
Protracted low level oxidative exposure can induce accumulated cell disruption , affecting multiple cellular functions.
Provider ' autonomy' , ' comfort ' level with existing tools , and ' learning curve ' were stated as barriers to use.
Provider feedback indicated screening procedures were complex.
Providers are encouraged to develop safe spaces for LGBT seniors.
Providers are responding through a variety of internal and collaborative models.
Provider skill has benefitted from improved training and recognition of high-risk situations.
Providers reported no patient complaints about the inclusion of sexual items on the intake form.
Providers should be aware that higher ERA scores can potentially predict outcomes in high-risk patients.
Providers should consider bringing up medication cost during glaucoma office visits to prompt a discussion of potential cost-related barriers to medication use.
Providers should consider discussing medication cost with patients to identify potential cost-related barriers to medication use.
Providers should consider these findings when discussing treatment timing , particularly with younger men diagnosed with early stage , low grade disease.
Provider training and tools about sexual health communication could help launch those discussions about sex and increase advocacy for older women's sexual health.
Provides a qualitative insight on the specific nature of heterosexual couples ' representations regarding the decision-making process for breast reconstruction after cancer.
provides quantitative estimates of fiber structure , which were shown to correlate with aging and focal entrapment.
Providing a social environment which encourages eating-with-others may benefit survival of older people , especially for men.
Providing care to a person with AD influences caregiver's life and leads to feelings of grief , which often precede caregiver depression.
Providing data regarding activity levels may improve patient motivation and assist clinicians with activity prescription.
Providing education , counseling , or materials without asking about firearm ownership was encouraged.
Providing education on the relationship between diet and blood pressure from an early age is most likely to produce tangible benefits.
Providing evidence of the benefit of cardiac drugs among the elderly with HF will become increasingly important as the size of the Medicare population grows.
Providing high-quality , evidence-based anesthetic and analgesic care for elderly patients undergoing elective operations on an ambulatory basis will assume greater importance in the future.
Providing relevant knowledge or making doctor recommendations might not be effective.
Providing strategies to fight against these age-related changes is a challenge for hair science.
Providing the brain with extra energy resources can help older adults achieve PEs even under demanding conditions.
Providing timely care may improve outcomes , as delay carries an increased risk of morbidity and mortality.
Providing transportation , home-based visits , and modest compensation may improve participation rates.
Proving influenza vaccine effectiveness requires appropriately powered RCTs , testing participants with RT-PCR tests , and comprehensively monitoring morbidity and mortality.
Provision data in hours per week and full-time equivalents and practice patterns were analyzed by health region.
Provision of adequate education in the domain of clinical geriatric pharmacology can improve recognition of ADRs.
Provision of appropriate refractive correction improves visual acuity in @percent@ subjects presenting with visual impairment.
Provision of combined interventions might enhance the improvements in functional independence in people with dementia over and above the interventions being used separately.
Provision of evidence-based preventive care in addition to HIV care is required for the aging population of PLWHA.
Provision of information and strengthening and protecting bones are important prevention measures.
Provocation studies presented in this article demonstrate that the response to electrosmog is physiologic and not psychosomatic.
Proxies of good health ( fewer co-morbidities and medications ) were not associated with better compliance to the ADG.
Proxies were carefully screened at ICU admission to choose the best available respondent.
Proxies were most commonly spouses ( @percent@ ) or children ( @percent@ ) .
Proximal and familial conditions influenced growth throughout infancy.
Proximal aortic cross-sectional-area changes during the cardiac cycle were determined using retrospective-ECG-gating on 128-detector row computed-tomography.
Proximal challenges define three mortality partitions : juvenile and adult extrinsic mortalities and intrinsic adult mortality.
Proximal femoral fracture has been increasing in @number@ and there are no reports that have decreased.
Proximal femoral fracture in osteoporotic fracture is related to the life prognosis in the most severe.
Proximal femur fractures are common in elderly osteoporotic patients.
Proximal femur integral vBMD , mid-thigh muscle area and muscle attenuation were assessed with computed tomography.
Proximal humerus fractures account for approximately @percent@ of all fractures.
Proximal humerus fractures are among the most common fractures associated with osteoporosis.
Proximal humerus fractures are the third most common fracture in elderly patients.
Proximally exposed dentin margins were not recordable by impressions , however , clinically no considerable problems like recurrent caries or discolorations were detected.
Proximally , medullary cavity volume was greater in the older groups in the tibia but not the fibula.
Proximity exhibits a strong effect on network structure , with provincial inter-organizational networks having more connections and thus a denser structure than interpersonal networks.
Proxy interviews were used to capture the majority of data in care homes.
Proxy variables and latent variable models are used to attempt to operationalize reserve.
PR patients have decreased longitudinal contribution to RVSV and increased lateral pumping , resulting in larger outer volume changes and septal motion towards the RV.
PrP conversion in PMCA was substantially less efficient with plasminogen-deficient brain material than with wild-type material.
PrPC was reduced by @percent@ ( p = 0.032 ) in the hippocampus in sporadic AD as compared to the age-matched controls.
PrPC was reduced in the hippocampus with aging ( rs = 0.03 ) .
PrP gene analysis revealed no mutations , and polymorphic codon @number@ exhibited Met / Val heterozygosity.
Pruritic diseases did not give significantly higher QoL1 or QoL2 scores compared with nonpruritic diseases ( P = @number@ Kruskall-Wallis test ) .
Pruritus in advanced age may result from a variety of etiologies , although xerosis is the most common.
Pruritus is an unpleasant sensation leading to the desire to scratch.
Pruritus may also be provoked by numerous drugs.
Pruritus occurs frequently in the elderly population , but it has not been fully defined and its precise prevalence is unknown.
PS1 also has functional interactions with many other proteins.
PS1 is a catalytic subunit of gamma-secretase and is also involved in the cleavage of many membrane proteins.
PS1 ΔE9 and C410Y FAD were found to lower PS1 gene expression in both cell lines , whereas PS1-M146V showed a neuron-specific effect.
PSA correlated inversely with HDL-chol and directly with TG / HDL-chol.
PSA showed a negative correlation with semen volume and total sperm count , and a positive correlation with semen interleukin-6.
PSC-CMs became similar to adult CMs in morphology , structure , and function within a month of transplantation into rats.
PS-containing liposomes ( PSLs ) can mimic the effects of apoptotic cells on phagocytes to induce the secretion of PGE ( @number@ ) .
PSD-95 , an important scaffolding protein that regulates synaptic distribution and activity of both NMDA and AMPA receptors , is also functionally disrupted by Aβ.
PSD-95 dysregulation is likely an important intermediate step in the pathological cascade of events caused by Aβ.
P-selectin membrane expression was evaluated using monoclonal antibodies.
Pseudoaccommodation from increased depth of focus may contribute to near vision functionality in Crystalens-implanted patients.
Pseudoaneurysm induced by trauma is known as a rare condition in peripheral arteries.
Pseudoneglect is a slight but consistent leftward attentional bias commonly observed in healthy young populations , purportedly explained by right hemispheric dominance.
Pseudophakia was independently associated with age , higher body weight and lower body height , diabetes and smoking.
Pseudoxanthoma elasticum-like papillary dermal elastolysis ( PXE-PDE ) and WFPN are further clinicopathologic patterns of intrinsic aging.
PS exposure was determined by annexin V binding and flow cytometry.
PSI was higher in women performing strenuous physical activity compared to inactive women ( β = @number@ @number@ @number@ ) .
PS mutations lead to familial AD , and although tau is not mutated in AD , tau pathology is a hallmark of the disease.
PS @number@ was correlated with higher incidence of severe AEs , premature treatment discontinuation , and worsening QOL after treatment.
PS-omega- @date@ serve as a safe alternative to phosphatidylserine extracted from bovine cortex.
Psoriasis is a common chronic inflammatory skin disease with a prevalence of about @percent@ in the Caucasian population.
PSQI scores did not significantly differ across the three ET cognitive groups ( p = 0.22 ) .
PS was assessed with the Number and Letter Sequencing conditions of the Delis-Kaplan Executive Function System Trail Making Test.
Psychache was significantly more intense in the HS group ( F ( @number@ ) = @number@ p < @number@ ) .
Psychiatric and somatic comorbidities as well as differences in buccal epithelial cells proportion may contribute to the observed epigenetic differences.
Psychiatric comorbidities are common in people living with HIV ( PLWH ) and adversely affect life satisfaction , treatment adherence and disease progression.
Psychiatric drug research needs to be grounded in a better understanding of molecular brain mechanisms , neural circuits , and their relations to clinical disease.
Psychiatric examination should be part of general management of adults with PWS , especially when caused by mUPD.
Psychiatric medications were in greater use in FTD than in AD ( @percent@ vs. @percent@ , respectively , P < 0.001 ) .
Psychiatric nurses and other mental health professionals may see an increase in older adults being referred for treatment.
Psychiatrists preferred unilateral ECT in the first instance with stimulus dosing based on patients ' seizure thresholds.
Psychical ageing refers to human awareness and his adaptability to the ageing process.
Psychoanalytic theory was often utilized to explain many common diseases.
Psychodynamic ( @percent@ ) , integrative ( @percent@ ) , and cognitive ( @percent@ ) orientations continue to prevail.
Psychoeducational interventions yield better results and can be better adapted to the needs of caregivers.
Psycho geriatric practices should direct their attention to loneliness when treating ADHD.
Psychol. , @number@ @number@ ) in ageing and in Alzheimer's disease ( AD ) .
Psychological conceptualizations of retirement are then discussed , and we link these conceptualizations to studying the changing nature of retirement.
Psychological correlates include anxiety , depression and irritability.
Psychological distress was assessed using the Kessler @number@ ( K6 ) scale.
Psychological distress was evaluated based on K6 scales at baseline and follow-up ( in @number@ ) .
Psychological distress was measured by the Kessler psychological distress scale.
Psychological distress was related to all three subjective memory-related outcome measures.
Psychological factors , although less studied in elders , are also important in understanding its cause.
Psychological functions are also thought to be decline in aging.
Psychological status was assessed using the Chinese version of the Purpose in Life scale.
Psychological stress has often been described as a feeling of being overwhelmed by the necessity of constant adjustment to an individual's changing environment.
Psychological sweating , or an increased sweat rate with the administration of the PASAT , was observed in both age groups in the high condition.
Psychologists and comparative musicologists , such as Carl Stumpf , thought in terms of multiple levels of sensory processing and mental representation.
Psychology and Aging , @number@ 677-689 ] .
Psychol Rep. @number@ ; 67 ( @number@ Pt @number@ ) : 1091-1100. doi : 10.2466 / pr0.1990.67.3f.1091 ) ( range : 11-55 ) .
Psychometric analyses indicated that mood and sleep quality improved for the MSDK group.
Psychometric analyses were conducted.
Psychometric Evaluation of the Hypogonadism Impact of Symptoms Questionnaire Short Form ( HIS-Q-SF ) .
Psychometric instruments used to assess efficacy included the Neuropsychiatric Inventory , hallucination subscale of the Positive and Negative Syndrome Scale , and Clinical Global Impression.
Psychometric properties and clinical utility of the resulting 31-item PACSLAC-II were examined.
Psychometric properties and factor structure were analysed , and factor scores created.
Psychometric properties were evaluated from the aspect of feasibility , internal consistency reliability , test-retest reliability , content validity , construct validity and discriminant validity.
Psychometric qualities of the 6CIT were evaluated for two different cut-offs.
Psychometric researches increase in Brazil.
Psychometric testing of the instrument supported its reliability and its convergent and content validity for assessing the residents ' QoL.
Psychopharmacological manipulations using cholinergic agonists and antagonists have been consistent in replicating patterns of aging seen in functional imaging studies.
Psychophysiological responses to disgusting and pleasant smells are one of the most important aspects of olfaction.
Psychosis incidence was related to cognitive status at all time points.
Psychosis is common in late-life and exacts enormous costs to society , affected individuals , and their caregivers.
Psychosocial factors ( depression , social network and social engagement ) were assessed during the CHAP interview.
Psychosocial factors including social network size and loneliness accounted for a sizeable proportion of the socioeconomic differential in RHR , particularly among men.
Psychosocial factors while acknowledged as important influences on recovery and healing remain an underdeveloped intervention toward improving the quality of cancer care.
Psychosocial intervention may be provided to minimize older adults ' communication barriers to pain management.
Psychosocial interventions have been effective in treating geriatric depression , either alone or better yet , in combination with antidepressant medications.
Psychosocial interventions have the potential to alleviate and prevent depression symptoms among older AMD patients.
Psychosocial interventions reported a moderate improvement on caregivers ' burden.
Psychosocial outcomes included depressive symptoms , positive affect , and negative affect.
Psychosocial research could be viewed as an investment in quality of care , rather than an academic achievement in a few centers of excellence.
Psychosocial resources included sense of mastery , self-efficacy , instrumental support and emotional support.
Psychosocial status was measured at baseline by the Center for Epidemiologic Studies Depression Scale and Norbeck Social Support Questionnaire.
Psychosocial stress and negative affect are linked to elevations in several inflammatory biomarkers.
Psychosocial work stress is a prevalent public health problem and may have an impact on zest for work.
Psychotherapy or sex therapy is useful for management of the psychological , relational , and sociocultural factors impacting a woman's sexual function.
Psychotherapy , social interventions and bibliotherapy all have an evidence-base for treating depression and anxiety in the elderly , as does pharmacological treatment.
Psychotic symptoms showed a good response to antibiotic treatment.
Psychotic symptoms were evaluated using the Consortium to Establish a Registry for Alzheimer's Disease Behavioral Rating Scale every @number@ months.
Psychotropic drug changes were ascertained from the facilities ' computerized medication administration log.
Psychotropic drugs were categorized by study doctors.
Psychotropic medication reduction would help address the problem of polypharmacy frequently seen in LTC facilities.
Psychotropic medications were assessed from the list of all medications recorded during a faceto- face interview.
Psychotropic medications were categorized by class.
Psychotropic medication use was higher in less urban areas ( @percent@ ) relative to more urban areas ( @percent@ ) , p = @number@
( PsycINFO Database Record
( PsycINFO Database Record Age-related macular degeneration ( AMD ) is the leading cause of vision loss among the elderly.
( PsycINFO Database Record A growing number of studies have reported age-related reductions in the frequency of mind wandering.
( PsycINFO Database Record BACKGROUND : Accumulating evidence points to the superiority of the MoCA over the MMSE as a cognitive screening tool.
( PsycINFO Database Record BACKGROUND AND PURPOSE : Drugs with anticholinergic properties might have a negative impact on cognition , but findings are still conflicting.
( PsycINFO Database Record BACKGROUND : Bioactive peptides have beneficial effects on the skin.
( PsycINFO Database Record BACKGROUND : Obesity is caused by an imbalance between energy intake , i.e. eating and energy expenditure ( EE ) .
( PsycINFO Database Record BACKGROUND : Postoperative delirium is a significant complication in elderly patients.
( PsycINFO Database Record BACKGROUND : The presence and extent of coronary artery calcium ( CAC ) are associated with increased risk for cardiovascular events.
( PsycINFO Database Record Being able to categorize promotes cognitive economy by reducing the amount of information that an individual needs to remember.
( PsycINFO Database Record Cataract surgery is the most frequently performed surgical procedure worldwide.
( PsycINFO Database Record ( c ) @number@ APA , all rights reserved ) .
( PsycINFO Database Record ( c ) @number@ APA , all rights reserved ) .
( PsycINFO Database Record ( c ) @number@ APA , all rights reserved ) .
( PsycINFO Database Record Deficits in sensory functioning , such as poor vision and hearing , take a significant toll on quality of life.
( PsycINFO Database Record Engagement in cognitively demanding activities has a positive impact on cognitive health in older adults.
( PsycINFO Database Record Families in Taiwan are considered central in caring for frail older people.
( PsycINFO Database Record Frequent social interactions are strongly linked to positive affect , longevity , and good health.
( PsycINFO Database Record In @number@ experiments , we examined reliance on age stereotypes when reconstructing the sources of statements.
( PsycINFO Database Record Interacting with older adults can trigger a number of stereotypes.
( PsycINFO Database Record It is well documented that well-being typically evinces precipitous decrements at the end of life.
( PsycINFO Database Record Most studies on personality and physical activity have relied on self-report measures.
( PsycINFO Database Record Negative age-related stereotypes often entail the perception that older adults have a lower social status than middle-aged adults.
( PsycINFO Database Record None : Literature suggests that pain perception diminishes in old age.
( PsycINFO Database Record Non-melanoma skin cancer and its precursor lesions are common diagnoses in dermatological practice , due to rising incidence and prevalence.
( PsycINFO Database Record Nordic welfare states have been very successful at reducing poverty and inequality among their citizens.
( PsycINFO Database Record OBJECTIVES : Disturbances in the hypothalamo-pituitary axis are supposed to modulate activity of multiple sclerosis ( MS ) .
( PsycINFO Database Record OBJECTIVES : The purpose of this study was to explore the pattern of mortality above the age of @number@ years.
( PsycINFO Database Record OBJECTIVES : To examine the association between hearing impairment and incident frailty in older adults.
( PsycINFO Database Record OBJECTIVE : To examine the association between long-term metformin therapy and serum vitamin B12 monitoring.
( PsycINFO Database Record Older adults show a preference for positive information , which disappears under high task demands.
( PsycINFO Database Record Photoplethysmographic imaging ( PPGI ) is a widefield noncontact biophotonic technology able to remotely monitor cardiovascular function over anatomical areas.
( PsycINFO Database Record Physical and imagined movements show similar behavioral constraints and neurophysiological activation patterns.
( PsycINFO Database Record Previous research has suggested age deficits in unimodal emotion recognition tasks.
( PsycINFO Database Record Previous research indicates age-related impairments in learning routes from a start location to a target destination.
( PsycINFO Database Record Psychological theories of aging highlight the importance of social context.
( PsycINFO Database Record PURPOSE : Cohorts allowing joint epidemiological and biological analyses are essential for radiation risk assessment.
( PsycINFO Database Record PURPOSE OF REVIEW : Autophagy promotes cellular health in response to various cellular stresses and to changes in nutrient conditions.
( PsycINFO Database Record Research on relationships between personality and cognitive abilities has so far resulted in inconsistent findings regarding the strength of the associations.
( PsycINFO Database Record Skeletal overgrowth is a characteristic of several genetic disorders that are linked to specific molecular signaling cascades.
( PsycINFO Database Record Terminal decline ( TD ) refers to acceleration in within-person cognitive decline prior to death.
( PsycINFO Database Record The facilitation of word processing by sentence context reflects the interaction between the build-up of message-level semantics and lexical processing.
( PsycINFO Database Record The presence of noise and interfering information can pose major difficulties during speech perception , particularly for older adults.
( PsycINFO Database Record The present work investigated associations of older people with humanness.
( PsycINFO Database Record The primary goal of this study was to address the stability-despite-loss paradox of subjective well-being.
( PsycINFO Database Record There is evidence for differential stability in personality trait differences , even over decades.
( PsycINFO Database Record This study examined the relationship of personal values to age using data from two representative surveys.
( PsycINFO Database Record Tumor-derived gangliosides in the tumor microenvironment are involved in the malignant progression of cancer.
( PsycINFO Database Record Views on aging are central psychosocial variables in the aging process , but knowledge about their determinants is still fragmental.
( PsycINFO Database Record We examined age-related differences in the reactive and proactive use of affect regulation strategies.
( PsycINFO Database Record We examined framing effects on exploratory decision-making.
( PsycINFO Database Record Young individuals better memorize initially seen faces with emotional rather than neutral expressions.
PT and ST groups showed significant improvements in KE and LP 1RM compared with the control group.
PTEN , a , serves dual roles as a tumor suppressor and regulator of cellular anabolic / catabolic metabolism.
PTEN is one of the most frequently mutated tumour suppressors and reduction in PTEN protein stability also plays a role in tumorigenesis.
PTEN is reversibly oxidized in various cells by exogenous and endogenous hydrogen peroxide.
PTEN is the major regulator of the PI3K / AKT / mTOR pathway and loss of PTEN promotes a senescence response termed PICS.
Pterygium was assessed using slit lamp biomicroscopy.
PTH also increases bone formation by stimulating the differentiation , maturation , and longevity of osteoblast lineage cells residing upon quiescent bone surfaces.
PTH increased active β-catenin staining in the osteoblast populations of both young and aged mice , but had a lesser effect in cartilage.
PTH increased cAMP production , ERK phosphorylation , and elevated intracellular calcium.
PTH resulted in sustained Col10a1 expression consistent with delayed chondrocyte maturation , but otherwise minimally altered cartilage gene expression.
PTHR internalization and recycling were measured in HEK-293 cells stably transfected with HA-PTHR.
PTH was unrelated to change in frailty status.
PT in selected patients aged ≥ @number@ years resulted in survival comparable with that of younger patients.
PTLD incidence is high immediately after transplantation , decreases subsequently , and then rises again 4-5 years from transplantation [ @number@ ] .
Pt-nps were functionalized by conjugation with this fusion protein at a 1 : 1 ratio of TAT-PtBP to Pt atoms.
Ptosis can usually be corrected surgically.
PTSD and subclinical PTSD were assessed in trauma-exposed women using diagnostic interviews.
PTSD is also associated with dementia.
PTSD symptoms were measured on the Harvard Trauma Questionnaire - part IV , which was the primary outcome measure.
PTSD symptoms were the dependent variable and number of combat experiences , apoE genotype , and the combat experiences × apoE genotype interaction were predictors.
PT significantly increased ( main time effect p < @number@ ) from the first to the third session , with no further improvements thereafter.
PTSS and health measures besides health-risk behaviors predicted subjective age.
PTSS was also associated with the EQ-5D-3L and the Satisfaction with Your Life Scale.
PTSS was associated with age , marital status , number of chronic disorders and the presence of an anxiety disorder.
PTSS was measured with the PTSS scale.
PTT and TSP were assessed before and after each exercise condition on the non-dominant arm and leg by computer-controlled cuff algometry.
PTX-3 might have an atheroprotective role as well as serving as a simple biomarker , like adiponectin.
Pubertal stage did not account for sex disparities.
Pubertal stage was significantly related to MD in diverse white matter regions.
Pubertal testosterone production was delayed , as were the growth spurt and pubic hair development.
Puberty and social anxiety did not relate to amygdala activation in response to fearful faces.
Puberty is a critical period of development during which sexual maturity is attained.
Publication bias was estimated using Egger's regression asymmetry test.
Publication bias was evaluated using Begg's test.
Publication bias was tested using Funnel plots.
Publications found through this indexed search were reviewed for further relevant references.
Publications found through this indexed search were reviewed for further relevant references.
Publications on the relationship of cataract to statins have reported inconsistent findings.
Public awareness of osteoporosis is low worldwide.
Public enlightenment would help to improve awareness of climacteric symptoms.
Public health agencies are facing a convergence of forces that require a reexamination of the existing paradigm.
Public health approaches for elderly persons should address early detection , prevention , and intervention programs for FOF.
Public health education and programmatic measures combining nutritional , physical and cognitive interventions for at-risk frail older people may likely benefit psychological wellbeing.
Public health efforts directed to the recognition and management of depression in people with tuberculosis may lead to better outcomes.
Public Health Implications.
Public health policies coupled with increased healthy lifestyle habits could minimize the prevalence and provide better quality of life for middle-age and older men.
Public health practitioners need to understand how local cultural practices influence early initiation of breastfeeding to promote adequate infant weight.
Public health research in this setting could inform criminal justice reform.
Public health strategies aiming to promote physical activity among older adults are increasingly being implemented.
Public health strategies could better explore this association.
Public Interest Alberta's Seniors Task Force members are deeply concerned about the privatization of long-term care in Alberta that began during the Klein era.
Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls.
Public payers should reconsider reimbursement of sedative-hypnotic drugs as first-line treatment for insomnia in older adults.
Public policy initiatives , such as the Province of Manitoba's Age-Friendly Initiative , may thus be one approach to enhancing healthy aging in rural settings.
Published BIA equations to estimate ASM should not be used indistinctly in other ethnic groups without validation.
Published by John Wiley & Sons , Ltd.
Published by John Wiley & Sons , Ltd.
Published by John Wiley & Sons , Ltd.
Published databases show either a significant decrease in Cd34 ( mouse ) or a trend toward decreased CD34 ( human ) in aging.
Published data from the Italian cancer registries were modeled in order to estimate regional cancer survival.
Published data from the Italian cancer registries were modeled in order to estimate the regional cancer survival.
Published data on this issue have been limited in Cambodia.
Published epidemiological studies have demonstrated that the risk of developing cancer is three times higher in the exposed individuals than in the general population.
Published guidelines and press releases were utilized as were the manufacturer's package inserts.
Published infraorbital scales to date have limitations in that they have been descriptive , subjective , or have used computer-generated images.
Published literature on the use and clinical outcomes of sacral nerve stimulation in older adults was reviewed and summarized.
Published @number@
Published peer-reviewed medical literature about AMH was searched through MEDLINE and was subjected to systematic review and critical assessment by the panel of authors.
Published PK data for FVIII from @number@ patients aged 1-74 years and for rFIX from @number@ patients aged 4-56 years were used.
Published studies to @date@ were included if they reported the YFAS diagnosis or symptom score and were published in the English language.
Publishing cognitive debriefing results helps researchers to determine potentially critical elements of the translated tools and assists with interpreting scores.
PubMed and Academic Search Complete were used with relevant terms.
PubMed and ISI Web of Science were searched up until @date@ .
PubMed and the International Association for Dental Research abstracts online were searched for laboratory studies on microtensile , macrotensile and macroshear bond strength tests.
PubMed and Web of Science were searched until @date@ .
PubMed , CINAHL , and PsycINFO were searched for studies published between @date@ and @date@ .
PubMed lists over @number@ references ( @number@ reviews ) on unintentional falls in older adults.
PubMed Medline and Embase were systematically searched for eligible articles.
PUBMED ( to @date@ ) was searched for longitudinal MRI studies reporting hippocampal atrophy or volume change in cognitively healthy individuals.
PubMed was the most precise , followed closely by Scopus and WOS.
Pubmed , Web of Science and Psychinfo were systematically screened for articles reporting motivators and barriers for physical activity.
Puerto Rican adults in the United States mainland live with socioeconomic and health disparities.
Puerto Rican adults living in the Boston area showed several metabolic abnormalities and high CVD risk , likely due to pervasive obesity and socio-economic disparities.
PUFA are hypothesized to influence bone health , but longitudinal studies on hip fracture risk are lacking.
PUFAs were assessed at study baseline through use of GC.
Pulegone , linalool , and citral showed knockdown percentages between @number@ and @percent@ , and mortality percentages between @number@ and @percent@.
Pulmonary aspiration is the consequence of abnormal entry of fluid , particulate material , or endogenous secretions into the airway.
Pulmonary capillary wedge pressure and LV end-diastolic volume were measured at baseline , during decreased and increased cardiac filling.
Pulmonary diseases have not been systematically assessed in the combination antiretroviral therapy ( ART ) era.
Pulmonary dysfunction is less well described.
Pulmonary fibrosis is a relatively rare but devastating disease characterized by the excessive deposition of extracellular matrix.
Pulmonary function and associated loss of optimal exercise capacity may have adverse effects on long-term quality of life in survivors.
Pulmonary function and FTSST may share similar sets of genes but in the negative direction.
Pulmonary function and muscle strength may have a shared environmental background.
Pulmonary function test results and BAL from patients with HPS1 and normal volunteers were examined for clinical correlation.
Pulmonary function tests included spirometry and arterial blood gases.
Pulmonary metastasis of breast cancer requires recruitment and expansion of T-regulatory cells ( Treg ) that promote escape from host protective immune cells.
Pulmonary outcome deteriorated significantly ( outcome score increased ) with age and American Society of Anesthesiologists ( ASA ) physical status.
Pulmonary vascular remodeling and vasoconstriction are recognized pathophysiological features of the disease.
Pulsatile GH secretion declines exponentially with age.
Pulsatility index ( PI ) and dynamic cerebral autoregulation ( dCA ) was assessed using transcranial Doppler ultrasound of the middle cerebral artery.
Pulse amplitude and pulse pressure were shown to correlate with age across the broader age range.
Pulsed radiofrequency ( PRF ) is a new method in the treatment of pain.
Pulse-pressure amplification reflects the augmentation of blood pressure between the central and peripheral arteries , which diminishes with aging.
Pulse pressure and mean arterial pressure were linked inversely only with lung function.
Pulse pressure and triglycerides were lower , high density lipids were higher , and a perceptual speed task and gait speed were better in LLFS.
Pulses from the dot handpieces were applied with @percent@ overlap.
Pulse wave velocity ( PWV ) is often used as a clinical index of aging , vascular disease , or age related hypertension.
Pulse wave velocity was determined using an automated waveform analyser.
PUMA knockdown protected the neurons against Aβ-induced apoptosis.
Punch biopsies ( @number@ mm ) were performed and a questionnaire was used to evaluate the patient's satisfaction and the incidence of adverse reactions.
Punch biopsies of the skin were taken to evaluate DNA damage by single cell gel ( comet ) assay.
Punch biopsy specimens of the sites were stained and labeled immunohistochemically with S100 , CD31 , and CD34 antisera.
Punished inefficiency proposes that having several physiologic impairments leads to physiologic inefficiencies.
Pupil size was measured continuously.
Pure alexia is an acquired reading disorder in which previously literate adults adopt a letter-by-letter processing strategy.
Purely lobar CMBs were not associated with incident dementia.
Pure-tone air conduction thresholds were collected in a sound-treated room for each ear at frequencies from @number@ through @number@ Hz.
Pure tone audiometry , tympanometry , and acoustic reflexes were performed.
Pure-tone averages ( PTA ) were calculated for the thresholds at @number@ @number@ and @number@ kHz in each ear.
Pure-tone test and tympanometry were performed @number@ h before and @number@ week after Gd administration.
\ "Pure \ " VaD was observed in @percent@ of the total cohort , decreasing from age @number@ to 90 + .
Puri and Sen Rank-Order L Statistics were used to analyse carry-over effects.
Purified CES1 and CES2 protein standards were used as calibrators , and the heavy labeled peptides were used as the internal standards.
Purified microglia-like cells were suitable for further culture and functional analyses.
Purified recombinant Plk3 , but not a kinase-defective mutant , phosphorylated HIF-1α in vitro , resulting in a major mobility shift.
Purified voacamine was very protective at low doses in all of the assays ( EC50s≤3.4 µM ) .
Purinergic and muscarinic agents produced similar effects in human urothelial tissue.
Purines are ubiquitous molecules with important roles in the regulation of metabolic networks and signal transduction events.
Purkinje cell dendritic anatomy was quantified using a Neurolucida microscopic system interfaced with a motorized stage.
Purkinje cell linear density was inversely associated with torpedo count ( r = @number@ P = @number@ ) .
Purkinje cell loss has been observed in some studies and is the focus of interest and debate.
Purkinje cell nuclei showed constantly positive signals for 5hmC.
Purple corn has been utilized as a daily food and exerts disease-preventive activities.
Purpose.
PURPOSE : Abnormal brain perfusion is a critical mechanism in neonatal brain injury.
PURPOSE : Access , enrollment , and engagement with primary and specialty health care services present significant challenges for rural populations worldwide.
PURPOSE : Active surveillance is becoming an increasingly common management strategy for low grade prostate cancer and involves repeat prostate biopsies over time.
PURPOSE : Adenoviral keratoconjunctivitis is a major cause of ocular morbidity and may lead to visual loss.
PURPOSE : Adequate conservative management of osteoporotic vertebral fractures remains important in an aging population.
PURPOSE : Adjuvant therapy reduces the risk of recurrence of breast cancer.
PURPOSE : Adults after surgical repair of tetralogy of Fallot ( ToF ) may have impaired vascular and cardiac autonomic function.
PURPOSE : African Americans are disproportionately affected by hypertension.
PURPOSE : Age as poor prognostic factor following nerve repair may be due to change in intraneural anatomy with age.
PURPOSE : Age-based reduction of chemotherapy dose with the first cycle ( primary dose reduction , PDR ) is not routinely guideline recommended.
PURPOSE : Age-related cataract ( ARC ) is a complex multifactorial disorder , including genetic and environmental factors.
PURPOSE : Age related cataract is the leading cause of blindness in the world today.
PURPOSE : Age-related eye disease is often considered part of natural aging.
Purpose : Age-related macular degeneration ( AMD ) commonly causes blindness in the elderly.
PURPOSE : Age-related macular degeneration is a leading cause of blindness in the elderly.
PURPOSE : Aging has severe implications for tissue damage and is a major risk factor for disease.
PURPOSE : Aging is associated with an impairment of blood lipids.
PURPOSE : Aging is associated with slow reactive movement generation and poor termination.
PURPOSE : Aging is known to influence temporal processing , but its relationship to speech perception has not been clearly defined.
PURPOSE : Aging of the vitreous body can result in sight-threatening pathology.
PURPOSE : Aim of the study was the analysis of cytokine expression in ankle osteoarthritis ( OA ) hypothesizing age-dependent regulation patterns.
PURPOSE : Alaska Natives ( ANs ) view aging from a holistic perspective , which is not typical of the existing successful aging literature.
PURPOSE : A link between poor sleep quality and Alzheimer's disease ( AD ) has recently been suggested.
PURPOSE : All structures of the spine , including the spinal canal , change continuously with age.
PURPOSE : Although physical activity is an established risk factor for chronic disease prevention , the specific mechanisms underlying these relationships are poorly understood.
PURPOSE : A new literature has suggested that speech rate can influence the parsing of words quite strongly in speech.
PURPOSE : An increase in lens thickness is often described as a linear function of age.
PURPOSE : Anisometropia shows an exponential increase in prevalence with increasing age based on cross-sectional studies.
PURPOSE : A retrospective study aiming to determine the extent of morphological changes of the pelvis related to the age of the subjects.
PURPOSE : As a cyclin-independent atypical CDK , the role of CDK5 in regulating cell proliferation in gastric cancer remains unknown.
PURPOSE : A self-paced maximal exercise protocol has demonstrated higher [ Formula : see text ] values when compared against traditional tests.
PURPOSE : A spontaneous frameshift mutation , c.3481delC , in the Crb1 gene is the underlying cause of dysplasia and retinal degeneration in rd8 mice.
PURPOSE : Astrocytes perform a plethora of important functions in the central nervous system ( CNS ) and are involved in cocaine-evoked synaptic plasticity.
PURPOSE : Benign prostatic hyperplasia and hypogonadism are common disorders in aging men.
PURPOSE : Black and White middle-aged adults typically are in a pivot position of providing support to generations above and below.
PURPOSE : Blood-brain barrier ( BBB ) damage aggravates perihematomal edema , and edema volume predicts prognosis independently.
PURPOSE : Blue-yellow visual-evoked potentials ( BY-VEPs ) may be used for diagnostics of functional ganglion cell damage in glaucoma and other ocular diseases.
PURPOSE : Breast cancer patients aged 65 + ( \ "older \ " ) vary in frailty status.
Purpose-built environments should be well suited to the needs of residents with dementia.
PURPOSE : Calorie restriction ( CR ) improves health span and delays age-related diseases in many species.
PURPOSE : Cardiovascular diseases are the leading cause of death and disability worldwide.
PURPOSE : Cataract is the world-leading cause of blindness.
PURPOSE : Cataracts are often considered to be an unavoidable consequence of aging.
PURPOSE : Caudal epidural block ( CEB ) , administered through the sacral hiatus , is a regional anesthetic technique commonly used in children.
PURPOSE : Cayenne aspiration is an unusual type of foreign-body aspiration that is usually misdiagnosed.
PURPOSE : Cerebral microvascular disease is associated with dementia.
PURPOSE : Cervical pain is very frequent in the general population.
PURPOSE : Changes in lens may reflect the status of systemic health of human beings but the supporting evidences are not well summarized yet.
PURPOSE : Childbearing delay contributes to the increase of subfertile couples that require assisted reproductive technology ( ART ) .
PURPOSE : Children with cerebral palsy have limited opportunities to explore their physical and social environment.
PURPOSE : Chronic hip pain is a common symptom experienced by many people.
PURPOSE : Chronic pain is highly prevalent in older adults.
PURPOSE : Clinical next-generation sequencing ( CNGS ) is introducing new opportunities and challenges into the practice of medicine.
PURPOSE : Clinical studies have reported a correlation between pelvic ischemia and voiding dysfunction in elderly men.
PURPOSE : CNS-directed chemotherapy ( CT ) and cranial radiotherapy ( CRT ) for childhood acute lymphoblastic leukemia or lymphoma have various neurotoxic properties.
PURPOSE : Comorbidity has a negative impact on quality of life ( QoL ) .
PURPOSE : Continuity and discontinuity are controversial concepts in social theories on aging.
PURPOSE : Correct drug prescription in the elderly is a difficult task that requires careful survey of the current pharmacological therapies.
PURPOSE : Critical illness results in derangements of all components of the immune response.
PURPOSE : Crowding describes the increased difficulty in identifying a target object when it is surrounded by nearby objects ( flankers ) .
PURPOSE : Currently , nearly @number@ in @number@ Americans is at least @number@ years of age.
PURPOSE : Does lumbar fusion lead to accelerated adjacent segment disc degeneration ( ASDD ) or is it explained by genetics and aging ?
PURPOSE : Dynamic visual acuity ( DVA ) is a relatively independent parameter for evaluating the ability to distinguish details of a moving target.
PURPOSE : Dysfunction of pelvic floor may cause many different symptoms , such as urinary and anal incontinence , obstructed defecation and constipation.
PURPOSE : Early-onset Alzheimer's disease ( EOAD ) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease ( LOAD ) .
PURPOSE : Elderly with dementia are often afflicted with sleep problems.
PURPOSE : Elevations in C-reactive protein ( CRP ) levels predict metastasis and mortality in a number of malignancies.
PURPOSE : Emerging data suggest that African-American women may fare worse than African-American men in health-related quality-of-life ( HRQOL ) .
PURPOSE : Emerging evidence suggests that exposure to endocrine disruptors may initiate or exacerbate adiposity and associated health problems.
PURPOSE : End-of-life care characteristics and palliative care ( PC ) utilization of elderly acute myeloid leukemia ( AML ) patients have rarely been reported.
PURPOSE : Endoscopic lasers have become a treatment option for benign prostate hyperplasia ( BPH ) .
PURPOSE : Endosonographic elastography has been introduced as a method of estimating the stiffness of pancreatic tumors.
PURPOSE : Epidemiological evidence suggests that ultraviolet ( UV ) irradiation and oxidative stress play an important role in age-related cataract pathogenesis.
PURPOSE : Epigenetic alterations in tissues targeted for cancer play a causal role in carcinogenesis.
PURPOSE : Epilepsy causes a significant burden to patients and to society.
PURPOSE : Epileptic spasms are seizures that occur predominantly in children and are characterized by clusters of brief axial movements.
PURPOSE : Evaluate brain iron accumulation in alcohol use disorder ( AUD ) patients compared to controls using quantitative susceptibility mapping ( QSM ) .
PURPOSE : Evaporation of the tear film is heavily discussed as one core reason for dry eye disease ( DED ) .
PURPOSE : Expectations regarding aging ( ERA ) in community-dwelling older adults are associated with personal health behaviors and health resource usage.
PURPOSE : Familial hemophagocytic lymphohistiocytosis type @number@ ( FHL3 ) is a genetic disorder that results in immune dysregulation.
PURPOSE : Few studies have focused on the aging changes in the upper eyelid.
PURPOSE : F-FDOPA is a highly sensitive and specific radiopharmaceutical for pheochromocytoma and paraganglioma ( PPGL ) imaging.
Purpose : For decades , scholars have studied the effects of immigration on the U.S. social security system.
PURPOSE : Frailty , a multifactorial biological syndrome characterized by a cumulative dysregulation of physiological processes , is associated with changes in pharmacokinetics and pharmacodynamics.
PURPOSE : Gait speed is related to physical function in older adults.
PURPOSE : Gastric emptying ( GE ) is often reported to be slower and more irregular in premature neonates than in older children and adults.
PURPOSE : Gender-related differences in life expectancy , prevalence of chronic conditions and level of disability in the process of ageing have been broadly described.
PURPOSE : Genes of androgen and estrogen signaling cells and stem cell-like cells play crucial roles in prostate cancer.
PURPOSE : Genetic factors contribute to the development and progression of age-related macular degeneration ( AMD ) .
PURPOSE : Given age-related health restrictions , the importance of the environment for life satisfaction may increase in later life.
PURPOSE : Glaucoma is an incurable chronic eye disease affecting a growing portion of the aging population.
Purpose : Growing evidence suggests the involvement of the macula even in early stages of glaucoma.
PURPOSE : Growing number of elderly lung cancer patients reflecting a lengthening life span has become a serious problem.
PURPOSE : Harmful alcohol consumption among the ageing population is an important public health issue.
PURPOSE : Health-related quality of life ( HRQOL ) after cancer diagnosis is prognostic for overall survival ( OS ) .
PURPOSE : Heart failure prevalence is increasing in older adults , and polypharmacy is a major problem in this population.
PURPOSE : High coronary calcium score ( CCS ) and post-procedural cardiac enzyme may be related with poor outcomes in patients with coronary stent implantation.
PURPOSE : Hip fractures are associated with poor prognosis in elderly patients partly due to the high rate of postoperative complications.
PURPOSE : HIV-related immunological and multisystem accelerated aging contributes to the premature occurrence of age-related comorbidities.
PURPOSE : How corneal transparency is formed / maintained remains largely unclear.
PURPOSE : Hypertension is one of the risk factors for cardiovascular diseases and stroke , and has a direct relationship with aging.
PURPOSE : Increasing diagnosis of small renal masses ( SRMs ) necessitates trainees to be familiar with available therapies.
PURPOSE : Individuals with developmental disabilities have poor eating habits and are at increased risk for cardiovascular disease , obesity , and osteoporosis.
PURPOSE : Informal caregivers of individuals with cancer may experience substantial burdens.
PURPOSE : Inguinal and femoral hernias are common disorders associated with aging.
PURPOSE : Inhibiting mechanistic target of rapamycin ( mTOR ) by pharmacological or genetic approaches can extend lifespan in mammals.
PURPOSE : In @number@ the Act on Welfare of Physically Disabled Persons was revised and the visual impairment grading methods were modified.
PURPOSE : In Ontario , stroke patients with relatively mild functional deficits are admitted to inpatient rehabilitation programmes.
PURPOSE : In recent years there has been a growing interest in nonsurgical procedures for facial rejuvenation.
Purpose is to evaluate the durability of two commonly used gastrostomy devices.
PURPOSE : It is a known fact that age is a strong predictor of adverse events in acute coronary syndrome ( ACS ) .
PURPOSE : Jerte Valley cherries contain high levels of tryptophan , serotonin , and melatonin.
PURPOSE : Limited empirical attention to date has focused on best practices in advanced research mentoring in the health services research domain.
PURPOSE : Limited information is available on the effect of Immediate Dentin Sealing ( IDS ) on the fracture strength of indirect partial posterior restorations.
PURPOSE : Lipofuscin ( LF ) accumulation within RPE cells is considered pathogenic in AMD.
PURPOSE : Listening in noisy situations is a challenging experience for many older adults.
PURPOSE : Lithium is a nutritionally essential trace element predominantly contained in vegetables , plant-derived foods , and drinking water.
PURPOSE : Little research has looked beyond individual factors to consider the influence of the neighborhood environment on cognitive function.
PURPOSE : Loneliness and depression are associated , in particular in older adults.
PURPOSE : Long-term cognitive impairment is a common and important problem in survivors of critical illness.
PURPOSE : Lymphatics subserve many important functions in the human body including maintenance of fluid homeostasis , immune surveillance , and tumor metastasis.
PURPOSE : Macular hole ( MH ) is part of a group of age-related degenerative diseases characterized by pathology of vitreomacular interface.
PURPOSE : Maintenance of cognitive abilities is important for elderly to stay independent.
PURPOSE : Many investigators have reported rising numbers of elderly patients admitted to the intensive care units ( ICUs ) .
PURPOSE : Many men receiving androgen deprivation therapy for prostate cancer experience hot flashes.
PURPOSE : Maxillofacial prostheses require enhancement or replacement due to deterioration in their color during service.
PURPOSE : Measurement of diurnal choroidal thickness in healthy eyes to investigate thickness variations.
PURPOSE : medication problems are thought to cause between @number@ and @percent@ of all hospital admissions in older people.
PURPOSE : Metabolic disorders , including MetS , obesity , and lipid disorders , may be related to genetic factors.
PURPOSE : Metabotropic glutamate receptor type @number@ ( mGluR5 ) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases.
PURPOSE : Methicillin-resistant Staphylococcus aureus ( MRSA ) is one of the leading causes of nosocomial infections.
Purpose : Microaneurysms are present in healthy old-age human retinas.
Purpose : Microaneurysms , considered a hallmark of retinal vascular disease , are present in aged retinas.
PURPOSE : Mild to moderate chest trauma is a common disease , although its clinical characteristics are not well known.
PURPOSE : Mitochondrial DNA ( mtDNA ) damage may be associated with age-related diseases , such as age-related macular degeneration ( AMD ) .
PURPOSE : Mobility disability is associated with poor lower body function among older adults.
PURPOSE : Muscle mass depletion is associated with adverse outcomes in cancer patients.
PURPOSE : Musculoskeletal conditions can impair people's ability to undertake physical activity as they age.
PURPOSE : Myeloproliferative neoplasms ( MPN ) are clonal disorders of hematopoietic stem- and progenitor cells.
PURPOSE : Myopia and astigmatism are highly prevalent in the Hong Kong Chinese.
PURPOSE : No studies quantify the labor market disparities between nurses with and without activity difficulties ( physical impairment or disability ) .
PURPOSE : Nuclear oxidative DNA damage increases with age in human corneal endothelial cells ( HCECs ) and contributes to their decreased proliferative capacity.
PURPOSE : Numerous studies have examined the association of physical , behavioral and social factors with cognitive decline in older adults.
PURPOSE / OBJECTIVES : To explore the perceptions of patients with breast cancer with mobility impairments of the physical accessibility of healthcare facilities and equipment.
PURPOSE / OBJECTIVES : To identify appropriate strategies for pharmacotherapeutic agents in the management of pain in older adults with cancer.
PURPOSE / OBJECTIVES : To present key recommendations from a recently released Institute of Medicine ( IOM ) report on high-quality cancer care.
PURPOSE OF REVIEW : Ageing is accompanied by a reduction in circulating testosterone and progressive accumulation of medical morbidities.
PURPOSE OF REVIEW : Aging is associated with a decline in cognition.
PURPOSE OF REVIEW : Both arthritis and foot pain are major public health problems.
PURPOSE OF REVIEW : Cachexia is a devastating complication of cancer for which there is no approved treatment.
PURPOSE OF REVIEW : Calcium crystals exist in both pathological and normal articular cartilage.
PURPOSE OF REVIEW : Cancer , aging , and cognition form a complicated interface that can challenge patients , caretakers , and healthcare professionals.
PURPOSE OF REVIEW : Cardioembolic stroke is common and disproportionately more disabling than nonembolic mechanisms of stroke.
PURPOSE OF REVIEW : Cardiovascular disease ( CVD ) is the leading cause of death and morbidity worldwide.
PURPOSE OF REVIEW : Cell based muscle tissue engineering carries the potential to revert the functional loss of muscle tissue caused by disease and trauma.
PURPOSE OF REVIEW : Childhood cancer survivors experience excessive weight gain early in treatment.
PURPOSE OF REVIEW : Chronic sarcoidosis is a complex disease with numerous comorbid conditions and can be fatal in some cases.
PURPOSE OF REVIEW : Description of management of diabetes in elderly.
PURPOSE OF REVIEW : Due to medical advances and an aging population , the number of cancer survivors continues to rise.
PURPOSE OF REVIEW : Epidemiological data show a continuous expansion of elderly population , associated with an increased demand for surgical treatments by older patients.
PURPOSE OF REVIEW : Fungal endocarditis remains a rare disease occurring mostly in patients with predisposing host conditions.
PURPOSE OF REVIEW : Ghrelin is a multifaceted gut hormone that activates its receptor , growth hormone secretagogue receptor ( GHS-R ) .
PURPOSE OF REVIEW : HIV infection is characterized by chronic immune system activation and inflammatory cytokine production.
PURPOSE OF REVIEW : In many countries , persons over @number@ are one of the fastest growing segments of the population.
PURPOSE OF REVIEW : Innovations in agriculture and medicine as well as industrial and domestic technologies are essential for the growing and aging global population.
PURPOSE OF REVIEW : Investigation into the underlying mechanisms of salt sensitivity has made important advances in recent years.
PURPOSE OF REVIEW : Late-life depression ( LLD ) presents in older adults as a heterogeneous mood disorder.
PURPOSE OF REVIEW : Levels of dehydroepiandrosterone ( DHEA ) are known to decline with age.
PURPOSE OF REVIEW : Manganese ( Mn ) is critical for neurodevelopment but also has been implicated in the pathophysiology of several neurological diseases.
PURPOSE OF REVIEW : Metabolic toxicities in HIV patients are common and contribute to clinical status and long-term sequelae.
PURPOSE OF REVIEW : Obesity and obesity-related diseases , largely resulting from urbanization and behavioral changes , are now of global importance.
PURPOSE OF REVIEW : Our purpose is to review recent findings highlighting the metabolic and functional diversity of HDL subspecies.
PURPOSE OF REVIEW : Patients with tetralogy of Fallot are subject to arrhythmic sequelae that substantially impact morbidity and mortality.
PURPOSE OF REVIEW : Physical inactivity in older adults is associated with declining functional capacity , sarcopenia , metabolic changes , and cognitive changes.
PURPOSE OF REVIEW : Podocytes are highly specialized epithelial cells that line the urinary surface of the glomerular capillary tuft.
PURPOSE OF REVIEW : Predicting fracture risk is a major challenge because it allows the prevention of major osteoporotic fracture in high-risk populations.
PURPOSE OF REVIEW : Recent research suggests that chronic obstructive pulmonary disease ( COPD ) may be a disease of accelerated aging.
PURPOSE OF REVIEW : Sinus node disease ( SND ) is a common clinical condition and is the most common indication for permanent pacemaker implantation.
PURPOSE OF REVIEW : Steps towards reducing chronic disease progression are continuously being taken through the form of genomic research.
PURPOSE OF REVIEW : Studies on collaborative and multidisciplinary approaches to the management of hypertension published in the past @number@ years are summarized.
PURPOSE OF REVIEW : The choice for an optimal treatment in older lymphoma patients is a real challenge for hemato-oncologists.
PURPOSE OF REVIEW : The frailty syndrome is characterized by an increased vulnerability to physiologic stress.
PURPOSE OF REVIEW : The musculoskeletal system is largely regulated through dynamic physical activity and is compromised by cessation of physical loading.
PURPOSE OF REVIEW : The pathogenesis of lung cancer and pulmonary fibrotic disorders partially overlaps.
PURPOSE OF REVIEW : The population over age @number@ is growing more rapidly than the general population.
PURPOSE OF REVIEW : There has been growing evidence that lifestyle factors may affect the health and lifespan of an individual by affecting telomere length.
PURPOSE OF REVIEW : There have been numerous published reports describing skeletal differences between males and females.
PURPOSE OF REVIEW : The renin-angiotensin system ( RAS ) is critical for cardiovascular control , impacting normal physiology and disease pathogenesis.
PURPOSE OF REVIEW : The role of bone-derived factors in regulation of skeletal muscle function is an important emerging aspect of research into bone-muscle crosstalk.
PURPOSE OF REVIEW : This article provides a practical clinical approach for the role of exercise in the treatment and management of neurologic disorders.
PURPOSE OF REVIEW : This review examines recent developments regarding the care of the elderly transgender patient.
PURPOSE OF REVIEW : This review highlights some of the important changes in the immune system that occur in the process of normal aging.
PURPOSE OF REVIEW : This review summarizes recent research on chronic obstructive pulmonary disease ( COPD ) among older adults.
PURPOSE OF REVIEW : This review synthesizes recently published information regarding nutrition and its impact upon epigenetically mediated mechanisms involved in longevity and aging.
PURPOSE OF REVIEW : To describe how to better identify frail multiple myeloma patients and to treat them appropriately.
PURPOSE OF REVIEW : To discuss brain changes associated with age-related hearing loss ( ARHL ) , including cognitive abilities and neuroimaging findings.
PURPOSE OF REVIEW : To explore recent findings bridging childhood development and common late-life mental disorders in the elderly.
PURPOSE OF REVIEW : To give an overview of recent research findings and insights on the role of body composition assessment in fracture risk prediction.
PURPOSE OF REVIEW : To highlight the recent evicence for optimal protein intake and protein supplementation in older adults.
PURPOSE OF REVIEW : To provide an objective and comprehensive review of the recent literature addressing the effects of sex on protein metabolism.
PURPOSE OF REVIEW : To review evidence on the validity and utility of recent approaches to subtyping late-life mild cognitive impairment.
PURPOSE OF REVIEW : To review the associations among age-related cataract , frailty , and frailty outcomes ( e.g. , disabilities ) .
PURPOSE OF REVIEW : To review the current evidence in diagnosing olfactory disorders and suggest an algorithmic approach to patients with relevant complaints.
PURPOSE OF REVIEW : To review the recent findings on the relationships between delirium and cognitive decline in the elderly.
PURPOSE OF REVIEW : To summarize the findings of the recent publications on sickle cell bone disease ( SBD ) .
PURPOSE OF REVIEW : To underscore recent clinical studies , which evaluate the association between dietary protein and bone health.
PURPOSE OF REVIEW : Transplantation of the elderly often invokes strong and sometimes passionate arguments both in support and in opposition.
PURPOSE OF REVIEW : Urinary incontinence is a common clinical problem , particularly in older adults.
PURPOSE OF REVIEW : We aimed to summarize recent findings in cervical ( CeAD ) and intracranial artery dissection ( IAD ) research.
PURPOSE OF REVIEW : With progressive age , the immune system and the propensity for abnormal immunity change fundamentally.
PURPOSE OF REVIEW : With the overwhelming success of combination antiretroviral therapy , HIV infection is now a chronic , but manageable , medical condition.
PURPOSE OF STUDY : Dementia affects more than @number@ million Americans , and is a leading cause of death.
PURPOSE OF STUDY : To assess suitability of current normative tables to evaluate hand and grip strength in clinical practice.
PURPOSE OF STUDY : To determine the effects of ageing and training experience on attitude towards performing basic life support ( BLS ) .
PURPOSE OF THE REVIEW : The number of adults who are aging successfully and have HIV infection is increasing.
PURPOSE OF THE STUDY : Adult children are often directly affected by aging parents ' decision to limit or stop driving.
PURPOSE OF THE STUDY : Adults with HIV infection are living into old age.
PURPOSE OF THE STUDY : As the prevalence of dementia increases , the pressure to make early diagnoses also increases.
PURPOSE OF THE STUDY : Caregivers of persons with dementia living at home adopt a variety of caregiving styles that vary in quality.
PURPOSE OF THE STUDY : Comprehensive measures of disability accommodations have been lacking in national health and aging studies.
PURPOSE OF THE STUDY : Hospital clinicians are overwhelmed with the volume of patients churning through the health care systems.
PURPOSE OF THE STUDY : Investigating health disparities requires studies designed to recruit and retain racially and socioeconomically diverse cohorts.
PURPOSE OF THE STUDY : Life events are associated with the health and well-being of older adults.
PURPOSE OF THE STUDY : Older Americans contemplating retirement today face a very different economic environment than prior cohorts did.
PURPOSE OF THE STUDY : Populations in Latin America , Asia and sub-Saharan Africa are rapidly ageing.
PURPOSE OF THE STUDY : Previous research found that \ "fun on line \ " is the most dominant content in seniors ' online communities.
PURPOSE OF THE STUDY : Social relations are a key aspect of aging and the life course.
PURPOSE OF THE STUDY : The process of involving older clients with regard to their care arrangements has been the subject of previous studies.
PURPOSE OF THE STUDY : This article examines the impact of early- and later-life circumstances on loneliness among people aged 65 + in Ireland.
PURPOSE OF THE STUDY : This study identified factors associated with canceling nonemergency medical transportation appointments among older adult Medicaid patients.
PURPOSE OF THE STUDY : To describe key adaptive challenges and leadership behaviors to implement culture change for person-directed care.
PURPOSE OF THE STUDY : To examine alternative means of mobility that nondriving older adults rely on and their impact on well-being.
Purpose of the study was to analyze whether and how studies of interventions consider effects on social inequalities in physical activity among older adults.
Purpose of the work is to select the indices of immunograms , associated with immunosenescence.
Purpose of this review of literature published between @number@ and @number@ was to provide up-to-date information on pathogenesis , diagnostic approach and treatment recommendations.
PURPOSE : Older adults in prison present a significant health and human rights challenge for the criminal justice system.
PURPOSE : Osteoporosis poses a great threat to the aging society.
PURPOSE : Osteoporotic hip fractures represent a particularly high burden in morbidity- , mortality- and health care-related costs.
PURPOSE : Our ability to flexibly coordinate the available degrees of freedom allows us to perform activities of daily living under various task constraints.
PURPOSE : Our study aimed to assess the longitudinal association of frequency of contact with non-cohabitating adult children and risk of depression in the elderly.
PURPOSE : Owing to the large aging population , a growing number of elderly patients are undergoing surgical treatment.
PURPOSE : Oxidative stress and DNA damage contribute to the pathogenesis of age-related cataract ( ARC ) .
PURPOSE : Perception of circular disconnected contours requires the integration of relevant local orientation information across space and the suppression of irrelevant orientations.
PURPOSE : Periprosthetic fractures of the femur are increasing due to the increase of arthroplasties and the aging population.
PURPOSE : Persons with mild dementia experience multiple losses and manifest depressive symptoms.
PURPOSE : Pilocytic astrocytoma ( PA ) is a World Health Organization grade I neoplasm that generally follows a benign course.
PURPOSE : Postoperative cognitive decline in the elderly has emerged as a major health concern.
PURPOSE : Postoperative pancreatic fistula ( POPF ) is one of the major complications in patients who undergo distal pancreatectomy ( DP ) .
PURPOSE : Postvertebral augmentation vertebral compression fractures are common ; repeated vertebral augmentation is usually performed for prompt pain relief.
PURPOSE : Preference-based generic measures are gaining increased use in mobility research to assess health-related quality of life and wellbeing.
PURPOSE : Previous studies that measured liquefaction and oxygen content in human vitreous suggested that exposure of the lens to excess oxygen causes nuclear cataracts.
PURPOSE : Prostate-specific antigen ( PSA ) is the most important marker in the diagnosis and follow-up of patients with prostate cancer.
PURPOSE : Prosthesis color production and stability as a result of pore entrapment during mixing has not been investigated for maxillofacial silicone prostheses.
PURPOSE : Quantifying the extent of conjunctival fibrosis for documentation of progression in conjunctival scarring disease is a clinical challenge.
PURPOSE : Radioresistance is a major cause of treatment failure of radiotherapy ( RT ) in human cancer.
PURPOSE : Raman spectroscopy is an effective probe of advanced glycation end products ( AGEs ) in Bruch's membrane.
PURPOSE : Recent evidence indicates that caffeine may have a beneficial effect on cognitive decline and dementia.
PURPOSE : Recent research suggests that hearing loss , a frequent problem for aging adults , is more prevalent in people with diabetes.
PURPOSE : Recent studies have suggested that adiponectin ( APN ) is associated with several retinal diseases.
PURPOSE : Recognition of injury to the hyoid bone is intrinsic to post-mortem examination.
PURPOSE : Regular physical exercise is recommended for the prevention and treatment of cardiovascular disease.
PURPOSE : research has established that attitudes can influence behavior.
PURPOSE : Results from a number of studies have suggested a relationship between cognitive alteration and benzodiazepine use in the elderly.
PURPOSE : Retrospective studies of inpatients with cancer suggest that a cancer diagnosis confers a high risk of falls.
PURPOSE : Revealing the relationship between mobility impairment and life satisfaction can help to propose effective interventions to secure mobility and life satisfaction.
PURPOSE : Sample entropy ( SampEn ) is an analysis to evaluate movement complexity of the center of pressure ( COP ) .
PURPOSES : Colonoscopic evidence of epidemiological trends in diverticulosis and diverticular bleeding is scarce.
PURPOSE : Searching for diagnostic and prognostic biomarkers for prostate cancer ( PC ) is main public health priority.
PURPOSE : Self-perceptions of health vary depending on one's social and cultural context.
PURPOSES : In this research , the association between administrators ' education and quality of nursing home care is examined.
PURPOSE : SIRT1 , the most well-known sirtuin family ( class III histone deacetylases ) member , is involved in many age-related diseases.
PURPOSE : Skeletal muscles of older individuals have a larger amount of intramuscular adipose tissue ( IntraMAT ) than those of younger individuals.
PURPOSE : Smoking cessation has been shown to normalize the coronary endothelial dysfunction in healthy young smokers.
PURPOSE : Social isolation is associated with suicidal ideation ( SI ) and self-harm ( SH ) among adolescents.
PURPOSE : Sorafenib is the standard of care for advanced hepatocellular carcinoma ( HCC ) .
PURPOSES : Recognizing gender-specific behavioral risks of type @number@ diabetes is important in improving the disease associated health outcomes and healthcare service.
PURPOSES : The study sets the stage for temporal information processing as a fundamental basis of human cognition and a novel neurorehabilitation method.
PURPOSES : To assess the accuracy of estimates using statistical databases of influenza-associated morbidity and mortality , and precisely measure influenza vaccine effectiveness.
PURPOSE : Studies have previously examined the relation between a single measure of plasma fatty acids and risk of heart failure.
Purpose : Studies suggest that deficits in auditory processing predict cognitive decline and dementia , but those studies included limited measures of auditory processing.
PURPOSE : Surgical options in the treatment of recurrent anterior shoulder instability are numerous.
PURPOSE : Survivors of childhood cancer are at an increased risk of developing subsequent neoplasms.
PURPOSE : The African-American-white mortality gap for males in the United States is @number@ years in favor of whites.
PURPOSE : The aging population is at risk of common eye diseases , and routine eye examinations are recommended to prevent visual impairment.
PURPOSE : The aging population is predisposed to cardiovascular disease.
PURPOSE : The aim is to systematically assess the effectiveness and safety of Chinese herbal formula Erxian decoction ( EXD ) for treating osteoporosis.
PURPOSE : The aim of an article is to introduce and elaborate on the available literature concerning eyeball development.
PURPOSE : The aim of the present investigation was to assess the role of aging on the contribution of diastolic function during metaboreflex activation.
PURPOSE : The aim of the study was the presentation of osteoporotic fracture prediction in men.
PURPOSE : The aim of this paper is to demonstrate how informatics applications can support the assessment and visualization of older adults ' wellness.
PURPOSE : The aim of this study was to describe the prevalence of and factors associated with vitamin D deficiency among Mexican older adults.
PURPOSE : The aim of this study was to determine if Demodex infestation is more frequent in contact lens wearers than in nonwearers.
PURPOSE : The aim of this study was to evaluate age-related changes in muscle fatigue of erector spinae muscle in men and women.
PURPOSE : The aim of this study was to evaluate corneal parameters obtained by Scheimpflug imaging of dermatochalasis patients both preoperatively and after blepharoplasty.
PURPOSE : The aim of this study was to highlight growing evidence of interactions between hormones and the structure and function of the auditory system.
PURPOSE : The aim of this study was to investigate the interaction between BMI and PA with HRQL in younger and older Canadian adults.
PURPOSE : The aim of this study was to propose a version of the ICF core set to classify the physical health of older adults.
PURPOSE : The American Society of Clinical Oncology ( ASCO ) published a study in @number@ that anticipated a shortage of oncologists by @number@
PURPOSE : The association between excess calcium intake and cardiovascular mortality has already been reported.
PURPOSE : The choroid plays a vital role in the health of the outer retina.
PURPOSE : The clinical effects of osteoporosis include pain , fractures , and physical disability , causing a loss of independence and necessitating long-term care.
PURPOSE : The clinical value of electroencephalography ( EEG ) in pediatric moyamoya disease has been underestimated , though the characteristic patterns are well known.
PURPOSE : The current study evaluated the effect of accelerated aging on the color and opacity of resin cements.
PURPOSE : The effect of cataract and other media opacities on functional vision is typically assessed clinically using visual acuity.
PURPOSE : The effects of lumbosacral and spinal orthoses on low back pain and gait are not exactly clear.
PURPOSE : The human corneal endothelium has a very low mitotic rate , and with aging there is a decrease in the number of cells.
PURPOSE : The impact of cataract maturity on the aqueous humor ( AH ) oxidant / antioxidant balance is largely controversial.
PURPOSE : The incidence of Alzheimer's disease ( AD ) has been steadily increasing worldwide.
PURPOSE : The incidence of hepatocellular carcinoma ( HCC ) in the elderly population has recently been increasing.
PURPOSE : The Incremental Shuttle Walk Test ( ISWT ) is an important functional and prognostic marker in chronic disease.
PURPOSE : The magnitude of the far interpupillary distance ( FIPD ) has recognized significance within and beyond clinical optometry.
PURPOSE : The maximum isometric force production capacity of the fingers decreases with age.
PURPOSE : The National Breast and Cervical Cancer Early Detection Program through each state's administration serves millions of low-income and uninsured women aged 40-64.
PURPOSE : The new Lenstar biometry device was compared in a typical clinical setting to the IOL-Master and Visante-OCT.
PURPOSE : The number of elderly inpatients has been steadily increasing worldwide.
PURPOSE : The number of women attempting to conceive between the ages of @number@ and @number@ has increased significantly in the last decade.
PURPOSE : The objective of the study was to examine the association between @number@ physical diseases and death by suicide in older adults.
PURPOSE : The objective of this systematic review was to synthesize evidence on the effectiveness of interventions aimed at promoting work participation in older workers.
PURPOSE : The Physical Mobility Scale ( PMS ) is used to evaluate the functional ability of aged adults.
PURPOSE : The present study aimed to investigate the association between hypertension and physical / functional capacities in community-dwelling older females.
PURPOSE : The present study aims to explore relationships between footedness and posturographic assessment in children aged from @number@ to @number@
PURPOSE : The present study examined the effect of aging on female reproductive potential.
PURPOSE : The prevalence of female homemakers ( those who stay at home to care for the home or family ) has increased to @percent@.
PURPOSE : The primary aim was to evaluate the influence of age on microvascular function in adults with similar PA levels.
PURPOSE : The proportion of the population , that is older , is growing at a faster rate than other age groups.
PURPOSE : The purpose of this article is to consider the implications of age-related cognitive decline for hearing health care.
PURPOSE : The purpose of this article is to improve quality in health care.
PURPOSE : The purpose of this article is to introduce the special research forum on sensory-processing changes in middle-aged adults.
PURPOSE : The purpose of this paper is to describe coping practices used by older women during preclinical disability.
Purpose The purpose of this paper is to explore the policy Implications of aging prison populations.
PURPOSE : The purpose of this study is to evaluate the feasibility and clinical outcomes of WheelSeeU.
PURPOSE : The purpose of this study was to assess the long-term functional status and quality of life of older individuals with functional mobility impairment.
PURPOSE : The purpose of this study was to evaluate the value of the TT-TG distance in patellar instability in the young athlete.
PURPOSE : The purpose of this study was to explore family caregivers ' role-implementation experiences at different stages of dementia.
PURPOSE : The purpose of this study was to quantify the age and race-related differences in the microstructural organization of the human posterior sclera.
PURPOSE : The purpose was to determine if the airways and lungs grow disproportionately from pre- to post-puberty in boys and girls.
PURPOSE : The quality of drug therapy is an important issue for nursing homes.
PURPOSE : The question of how and when English-speaking children acquire auxiliaries is the subject of extensive debate.
PURPOSE : There are marked differences in facial skeletal characteristics between Asian and Caucasian.
PURPOSE : There is a growing population of older people living alone within the context of dramatic population ageing and changing living arrangements.
PURPOSE : There is scant empirical work exploring academic physicians ' psychosocial adjustment during late-career transitions or on the factors that influence their retirement decisions.
PURPOSE : The relationship between spine and shoulder motion has not been well evaluated.
PURPOSE : The remaining bladder is an almost forgotten entity.
PURPOSE : The research aim was to identify demographic characteristics , chronic diseases , and unhealthy behaviors predicting ill health retirement in South Korea.
PURPOSE : The risk of breast cancer ( BC ) increases in parallel with increasing age.
PURPOSE : The study considers the social networks of older Americans , a population for whom there have been few studies of social network type.
PURPOSE : The study of auxiliary acquisition is central to work on language development and has attracted theoretical work from both nativist and constructivist approaches.
PURPOSE : The use of radiation , especially ionizing radiation ( IR ) , is currently attracting great attention in the field of medical sciences.
PURPOSE : The venous choroidal blood drains through the superior orbital vein into the intracranial cavernous sinus.
PURPOSE : This observational , microlongitudinal study examined whether depressive symptoms and sleep were sequential mediators of racial differences in endogenous pain facilitatory processes.
PURPOSE : This paper describes the steps of a demonstration project , the Elko Telehealth Outreach Clinic.
PURPOSE : This paper examines the influence of age on several attributes of sensorimotor performance while performing a reaching task.
PURPOSE : This quasi-experimental study evaluated the longitudinal impact of regular participation in a wellness exercise program on functional status of residents in assisted living.
PURPOSE : This research aimed to develop and evaluate a website with information on Speech-language therapy area with focus on the aging process.
PURPOSE : This research aimed to investigate whether demographic factors are similarly related to retrieval of object and proper names.
PURPOSE : This review synthesizes and characterizes findings related to the effects of yoga on depression and quality of sleep in the elderly.
PURPOSE : This study aimed to explore older adults ' perceptions of their daily lives in South Korean nursing homes.
PURPOSE : This study aimed to identify the relations among age and selected running biomechanics throughout the range of 18-60 yr.
PURPOSE : This study aims to compare running mechanics and lower-extremity coordination variability in matched groups of healthy younger and healthy older runners.
PURPOSE : This study aims to quantify the relation between elder self-neglect and rate of emergency department utilization in a community-dwelling population.
PURPOSE : This study assessed the effect of antioxidants vitamin C ( Vit.
PURPOSE : This study compared subjective and objective accommodative amplitudes to characterize changes from preschool to presbyopia.
PURPOSE : This study compared the efficacy of complicated grief therapy ( CGT ; Shear , K. [ @number@ ] .
PURPOSE : This study evaluated the adhesive quality of simplified self-adhesive and conventional resin cements to Y-TZP in dry and aged conditions.
PURPOSE : This study evaluated the effect of LTD on four types of Zirconia dental implants at @number@ @number@ and @number@ years of artificial aging.
PURPOSE : This study examined body-scaled information that specifies the reach patterns of children with hemiplegic cerebral palsy and children with typical development.
PURPOSE : This study examined subfoveal choroidal thickness ( SFCT ) in eyes with cataracts.
PURPOSE : This study examined the effects of matrix solutions and aging methods on the bond strength between resin composite and human dentin.
Purpose : This study examined the potential roles of phonological sensitivity and processing speed in age-related declines of verbal working memory.
PURPOSE : This study examined the relationship between sensory-processing patterns and occupational engagement among older persons.
PURPOSE : This study examines the prospective associations between a wide range of midlife determinants and objectively measured sedentary time in old age.
PURPOSE : This study investigated the influence of several methodological details on the shear bond strength ( SBS ) testing of pit and fissure sealants.
Purpose : This study sought to investigate the interaction of speech movement execution with higher order lexical parameters.
PURPOSE : This study was designed to examine speech understanding ability and temporal processing in middle-aged women with normal or near-normal pure-tone thresholds.
PURPOSE : This study was done to investigate factors influencing successful aging in middle-aged women.
PURPOSE : Threshold tracking is a new noninvasive approach for detecting axonal excitability changes in vivo.
PURPOSE : Thumb carpometacarpal ( CMC ) arthritis contributes considerably to functional disability in the aging adult United States ( US ) population.
PURPOSE : To analyze choroidal sub-layers and vascular diameter in children , and to compare these choroidal features with those of adults.
PURPOSE : To analyze the effect of education on sentence listening comprehension on cognitively healthy elderly.
PURPOSE : To analyze the influence of corneal thickness profile on posterior corneal astigmatism ( PA ) .
PURPOSE : To analyze the renal function outcomes in patients undergoing radiation therapy for neuroblastoma.
PURPOSE : To appraise psychometric properties of such tools , specifically predictive validity for on-road performance.
PURPOSE : To assess and compare the morphologic changes in the anterior segment in eyes with nuclear or cortical age-related cataract using Scheimpflug imaging.
PURPOSE : To assess long-term impairments of executive functioning in adult survivors of bronchopulmonary dysplasia ( BPD ) .
PURPOSE : To assess the benefits of cochlear implantation in the elderly.
PURPOSE : To assess the changes in intraocular pressure ( IOP ) with age in South Korea.
PURPOSE : To assess the degree of participation of the visually impaired elderly and to make a comparison with population-based reference data.
PURPOSE : To assess the effect of ageing on in vivo human ciliary muscle morphology and contractility during accommodation.
PURPOSE : To assess the effect of aging on optical quality in a normal population.
PURPOSE : To assess the effect of cataract on the evaluation of macular pigment optical density ( MPOD ) in aged patients.
PURPOSE : To assess the effect of increasing age on diagnostic accuracy of CDRs for VTE in elderly.
PURPOSE : To assess the factors involved in oral intake discontinuation in elderly patients with recurrent aspiration pneumonia.
PURPOSE : To assess the relationship between coronary atherosclerotic burden and vascular function in diabetic and nondiabetic patients after balancing for coronary risk factors.
PURPOSE : To assess the relationship between the prevalence and severity of conjunctivochalasis and pinguecula.
PURPOSE : To assess the relationship of posttraumatic stress disorder ( PTSD ) with health functioning and disability in Vietnam-era Veterans.
PURPOSE : To assess whether corrected visual acuity after implantation of diffractive multifocal intraocular lenses ( IOLs ) varies with patient age.
PURPOSE : To bring out the effect of the age and of a sagittal imbalance in the variability of the value of PI.
Purpose : To characterize age-related alterations in the retinal microcirculation , microvascular network , and microstructure in healthy subjects.
PURPOSE : To characterize the thickness profile of the corneal epithelium and the Bowman's layer across the horizontal meridian.
PURPOSE : To characterize the voice of elderly people engaged in aerobics.
PURPOSE : To clarify age-related structural changes specific to hippocampal volume by hierarchizing according to age , gender , and menopausal status.
PURPOSE : To clarify the redox states of the aqueous humor and serum in senile cataract patients.
PURPOSE : To compare age-dependent changes in health status among childhood cancer survivors and a sibling cohort.
PURPOSE : To compare the effects of the tongue-hold swallowing maneuver on pharyngeal pressure generation in healthy young and elderly research volunteers.
PURPOSE : To compare visual assessment of medial temporal lobe atrophy ( vaMTA ) with hippocampal volume in a healthy , non-demented elderly population.
PURPOSE : To define the term complexity of care.
PURPOSE : To demonstrate the effectiveness and value of a home-based information communication technology ( ICT ) training program for older adults.
PURPOSE : To describe age-related changes of different corneal layers using a quantitative analysis of in vivo corneal confocal microscopy.
PURPOSE : To describe a new method of measuring early phase tear clearance by anterior segment optical coherence tomography ( AS-OCT ) .
PURPOSE : To describe annual care transition patterns across residential and health care settings and assess consistency in care transition patterns across years.
Purpose : To describe the cumulative 6-year incidence of visual impairment ( VI ) and blindness in an adult Kenyan population.
PURPOSE : To describe the prevalence of cataract in older people in @number@ areas of north and south India.
PURPOSE : To describe the results of efforts to recruit Asian Americans into longitudinal research on cognitive decline in aging.
PURPOSE : To describe the use of hyaluronic acid gel for upper eyelid filling , contouring , and rejuvenation.
PURPOSE : To determine corneal Q value and its related factors in Chinese subjects older than @number@ years.
PURPOSE : To determine the association between glaucoma and travel away from home.
PURPOSE : To determine the clinical value and audiometric correspondence of self-reported hearing loss as a screening tool for the baby boomer population.
PURPOSE : To determine the cost-effectiveness of ocular hypertension ( OH ) treatment initiated with latanoprost compared to timolol.
PURPOSE : To determine the dose-dependent effects of testosterone administration on cognition in women with low testosterone levels.
PURPOSE : To determine the mean corneal power , astigmatism , and irregularity in a sample from the population of Tehran.
PURPOSE : To determine the most significant clinical predictors that influence driving ability in Parkinson disease ( PD ) .
PURPOSE : To determine the most valuable comorbidity index to apply in a clinical context and its prospective association with 1-year mortality and 3-month readmission.
PURPOSE : To determine the natural end-point for refractive development during childhood.
PURPOSE : To determine the prevalence of pinguecula and pterygium and to investigate their associations in a general adult population in North-Western Spain.
PURPOSE : To determine the prevalence of refractive conditions in the adult population that visited primary care optometry clinics in Puerto Rico.
PURPOSE : To determine the relation between ABI and the complexity of coronary artery disease , by different anatomical classifications.
PURPOSE : To determine the thickness of Bowman's layer ( BL ) in vivo in a healthy population and to determine its variation with age.
PURPOSE : To determine the vision status , ophthalmic findings , and quality of life among the very elderly.
PURPOSE : To determine whether intradermal facial onabotulinumtoxinA injection has any benefits.
PURPOSE : To determine whether people with age-related eye disease have lower cognitive scores than people with healthy vision.
PURPOSE : To determine whether the age effect earlier noted for a noise activator will be noted for a tonal activator.
PURPOSE : To determine whether various temporal processes decline with aging and whether some are more resistant to the effects of aging than others.
PURPOSE : To develop a French Canadian version of the Falls Behavioral ( FaB ) Scale and examine its psychometric properties.
PURPOSE : To develop a method for projecting the impact of ageing and changing drug utilization patterns on future drug expenditure.
PURPOSE : To develop an image analysis method that can automatically find correlations between a set of plain radiographs and continuous clinical or physiological indicators.
PURPOSE : To discover how 90-91-year-olds see a good old age and identify the dimensions of good and successful aging that appear in their talk.
PURPOSE : To establish a culturally appropriate interdisciplinary intervention model for preventing postoperative delirium in older Chinese patients.
PURPOSE : To establish mice model with periodontitis by oral infection with Porphyromonas gingivalis , simulating human periodontal disease.
PURPOSE : To estimate the 5-year incidence of cataract and cataract surgery in an adult Chinese population.
PURPOSE : To estimate the discriminative value of serum P1NP / βCTX ratio and albumin levels in hospitalized orthogeriatric patients with and without nonvertebral fractures.
PURPOSE : To evaluate age and secular changes in strength of rural Zapotec adults in Oaxaca between @number@ and @number@
PURPOSE : To evaluate blue-light attenuation in eyes with a tinted intraocular lens ( IOL ) or an untinted IOL.
PURPOSE : To evaluate bone age determination using MRI of the hand and wrist.
PURPOSE : To evaluate gluteus medius and minimus tendon pathology and muscle atrophy in older individuals using MRI.
PURPOSE : To evaluate the antibacterial , mechanical and biocompatibility characteristics of an orthodontic adhesive that contains quaternary ammonium polyethyleneimine ( QPEI ) nanoparticles.
PURPOSE : To evaluate the clinical usefulness of measuring the lacrimal sac fossa length using orbital computed tomography in normal Koreans.
PURPOSE : To evaluate the effect of chlorhexidine on the presence of collagen in aged resin-dentin bonds produced on sound and caries-affected dentin.
PURPOSE : To evaluate the effect of oxalate during total-etch bonding , under different dentin moisture conditions , over time.
PURPOSE : To evaluate the effects of aging on hand function among patients with tetraplegia who had forearm tendon transfer surgery between @number@ and @number@
PURPOSE : To evaluate the mechanical strength and color stability of provisional restoration materials.
PURPOSE : To evaluate the potential role of the matrix metalloproteinase ( MMP ) system of Bruch's membrane in the pathology of age-related macular degeneration.
PURPOSE : To evaluate the relationship between androgen levels and subjective and objective measures of dry eye syndrome ( DES ) .
PURPOSE : To evaluate topographic patterns in keratoconic cases and to classify those topographic patterns according to different age groups.
PURPOSE : To evaluate uterine senescence by comparing pregnancy rates in older recipients vs their younger donors who were actually trying to conceive themselves.
PURPOSE : To examine an association between the overactive bladder symptom score ( OABSS ) and neuropsychological parameters.
PURPOSE : To examine hippocampal differences between Alzheimer disease ( AD ) , amnestic mild cognitive impairment ( aMCI ) and normal aging.
PURPOSE : To examine if myopia is a risk factor for age-related cataract.
PURPOSE : To examine insurance regain among youth with no , nonsevere , and severe disabilities.
PURPOSE : To examine projections of age-related eye diseases in the United States for health care planning.
PURPOSE : To examine the association of cognitive function , age , and hearing loss with clinically assessed hearing aid benefit in older hearing-impaired persons.
PURPOSE : To examine the associations of nerve fiber layer ( NFL ) thickness with other ocular characteristics in older adults.
PURPOSE : To examine the contents and characteristics of seniors ' online communities and to explore their potential benefits to older adults.
PURPOSE : To examine the distribution and causes of corneal blindness in a rural Chinese population.
PURPOSE : To examine the effects of age and increased air velocity , during exercise in humid heat , on information processing and attention.
PURPOSE : To examine the effects of resistance training ( RT ) on metabolic syndrome-related phenotypes in postmenopausal women.
PURPOSE : To examine the impact of age and cognitive reserve on cognitive functioning in patients with breast cancer who are receiving adjuvant treatments.
PURPOSE : To examine the relation between various levels of alcohol intake and incident heart failure.
PURPOSE : To examine the scope of the peer-reviewed literature on the use of commercially available video gaming in rehabilitation.
PURPOSE : To examine when and how socially conditioned distinct speaking styles emerge in typically developing preschool children's speech.
PURPOSE : To examine whether suicides with circumstances related to economic crises increased disproportionately among the middle-aged between @number@ and @number@
PURPOSE : To explore and describe the ways in which older widows construct and perceive their sexuality along the life course.
PURPOSE : To explore the nature of men's experiences of osteoporosis by developing an understanding of men's explanatory models.
PURPOSE : To explore the relationship between chronic kidney disease and diabetic retinopathy in a representative population of Korean diabetic adults.
PURPOSE : To identify proteomic differences between age-related nuclear cataracts ( ARNCs ) and normal lens nuclei.
PURPOSE : To identify whether a history of cancer is associated with specific geriatric syndromes in older patients.
PURPOSE : To investigate choroidal thickness ( CT ) and its associations in children in a school-based study.
PURPOSE : To investigate differences in the age-related decline in brain tissue concentration between Masters athletes and sedentary older adults.
PURPOSE : To investigated the prevalence and risk factors of epiretinal membrane ( ERM ) .
PURPOSE : To investigate the age-related changes in human palpebral conjunctiva and meibomian glands by in vivo confocal microscopy.
PURPOSE : To investigate the association between sex hormone deficiency and soft drusen in women and men.
PURPOSE : To investigate the auditory behavior of patients with chronic renal failure ( CRF ) undergoing kidney transplantation.
PURPOSE : To investigate the correlation between aqueous flare values and central visual function in patients with retinitis pigmentosa ( RP ) .
PURPOSE : To investigate the effects of aging on normal Korean hair diameter and surface features using AFM.
PURPOSE : To investigate the effects of aging on postural control and cognitive performance in single- and dual-tasking.
PURPOSE : To investigate the effects of a secondary task on standing balance in patients with glaucoma or AMD compared with age-similar control subjects.
PURPOSE : To investigate the influence of age on arterial stiffness and blood pressure after performing a resistance exercise bout.
PURPOSE : To investigate the relationship between maximal dynamic strength and site-specific muscle mass of the thigh and upper arm.
PURPOSE : To investigate the relationship between the central spatial profile of macular pigment optical density ( MPOD ) and increasing age in normal eyes.
PURPOSE : To investigate the reliability of a 3D-accelerometry based gait analysis , and its correlates with clinical status and fall-risk.
Purpose : To investigate the role of sunlight exposure in iris freckles formation.
PURPOSE : To investigate whether acquired somatic mutations in the iron response element of the ferritin L-chain gene account for the age-related cataract.
PURPOSE : To investigate whether macular pigment optical density ( MPOD ) is related to dark adaptation in healthy subjects.
PURPOSE : To measure choroidal thickness and to determine parameters associated with it.
PURPOSE : To measure the concordant changes in morphology of the discs and vertebrae during 5- , 10- , and 15-year follow-ups.
PURPOSE : To present four different cases with a diagnosed cemental tear.
PURPOSE : To provide an overview of factors influencing the acceptance of electronic technologies that support aging in place by community-dwelling older adults.
PURPOSE : To quantitatively assess the histological and ultrastructural changes resulting from aging in the human testis.
PURPOSE : to reassess the adrenal function of patients with PCOS after the introduction of the Rotterdam's criteria.
PURPOSE : To report the 7-year incidence of age-related cataracts in a metropolitan Chinese elderly population.
PURPOSE : To report the development of bilateral retinal detachment in a patient with Werner syndrome.
PURPOSE : To report the method and results of 18-point Abobotulinum toxin A ( ABO-BTA , Dysport ) upper face rejuvenation on @number@ subjects.
PURPOSE : To report the refractive changes after cataract surgery and intraocular lens ( IOL ) implantation in Hong Kong Chinese children.
PURPOSE : To review findings from major epidemiologic studies regarding risk factors for and consequences of elevated markers of inflammation in older adults.
PURPOSE : To review the uniqueness of the Amish culture and evaluate the published research on cardiovascular disease and associated risk factors in the Amish.
PURPOSE : To study and analyze astigmatism and its characteristics in a cross-sectional study of schoolchildren from Dezful , Iran.
PURPOSE : To study binocular and accommodative characteristics and their associations with age and gender in an Iranian young adult population.
PURPOSE : To study the effect of age and gender on mean WSS ( MWSS ) values in major cerebral arteries.
PURPOSE : to study the hour-to-hour relationships between weather factors and objectively measured walking and cycling in a sample of Dutch older adults.
PURPOSE : To summarize the available evidence regarding the relationship between joint loading and the prevalence and progression of BMLs in the tibiofemoral joint.
PURPOSE : To test the efficacy of two maintenance prescriptions on muscle mass , myofiber size and type distribution , and strength.
PURPOSE : To test the marginal adaptation of Class IV restorations made of different composite materials designed for anterior use.
PURPOSE : To test the relationship between degree of hearing loss and different memory systems in hearing aid users.
PURPOSE : To validate and evaluate the reliability of retinal vessel diameter measurements by optical coherence tomography ( OCT ) .
PURPOSE : To verify the relationship between CVD risk factors and the frailty syndrome in community-dwelling elderly.
PURPOSE : Trauma is a common cause of admission to the hospital emergency department.
PURPOSE : Trypan blue ( TB ) is used for visualization of the endothelium-Descemet membrane graft during Descemet membrane endothelial keratoplasty ( DMEK ) .
PURPOSE : Understanding the long-term outcomes of developmental language difficulties is key to knowing what significance to attach to them.
PURPOSE : Urbanization may promote the rise of dual burdens of underweight and overweight in low- and middle-income countries.
PURPOSE : Ventral abdominal wall hernias are common and repair is frequently associated with complications and recurrence.
PURPOSE : Visualization of the spatial distribution of neurofibrillary tangles would help in the diagnosis , prevention and treatment of dementia.
PURPOSE : Volunteering among older adults has received increasing attention from researchers , policy makers , and associations.
PURPOSE : Wartime combat exposure is linked to a broad array of negative outcomes.
PURPOSE : We aimed to elucidate the associations among physical activity , sedentariness , and EDS in middle-aged and older adults.
PURPOSE : We aimed to explore operational definitions of mixed urinary incontinence ( MUI ) for use in incontinence outcomes research for non-surgical patient populations.
Purpose : We aimed to visualize the relationship of predominant dietary patterns and their associations with AMD.
PURPOSE : We assessed changes in the position of the lens with aging in a general population.
PURPOSE : We assessed the risk of exstrophy-epispadias complex in children conceived by in vitro fertilization or intracytoplasmic sperm injection.
PURPOSE : We conducted a meta-analysis to evaluate the relationship between smoking and age-related cataract ( ARC ) .
PURPOSE : We describe the recruitment strategies and personnel and materials costs associated with two community-based research studies in a Mexican-origin population.
PURPOSE : We estimated the prevalence of nocturia in the United States male population and identified associated factors.
PURPOSE : we evaluated mortality risk in relation to social vulnerability across levels of frailty among a cohort of older Japanese-American men.
PURPOSE : We examined the association between military exposure and urinary incontinence in American men.
PURPOSE : We explored an innovative technique in treating mycotic aortic aneurysms.
PURPOSE : We explored changes in muscle interactions during healthy aging as a window into neural control strategies of postural preparation to action / perturbation.
PURPOSE : We investigated age related changes in urodynamic parameters in @number@ large cohorts of women planning stress urinary incontinence surgery.
Purpose : We investigated cerebral small vessel disease ( SVD ) in patients with incidental retinal vein occlusion ( RVO ) .
PURPOSE : We investigated whether lifelong football training affects the expression of healthy longevity-related muscle molecular markers.
PURPOSE : We located the instantaneous center of rotation ( ICR ) for the cervical spine at various ages and investigated age-related changes.
PURPOSE : We measured scleral thickness in eyes of Chinese , and assessed interregional differences and associations with age and axial length.
PURPOSE : We recorded oscillatory potentials ( OPs ) to document how age impacts on rod- and cone-driven inner retina function.
PURPOSE : Werner syndrome is an autosomal recessive disease of premature aging caused by a polymorphic C1367T mutation in the Werner ( WRN ) gene.
PURPOSE : We sought to determine whether widowhood-associated excess mortality differs by gender in terms of causes of death.
PURPOSE : We sought to examine how different activities performed during employment gaps are associated with later cognitive function and change.
PURPOSE : We tested whether higher baseline psychological well-being predicted higher levels of physical activity over time.
PURPOSE : Whether age and inter-individual variability of pharmacogenetics are risk factors for paclitaxel-induced peripheral neuropathy ( PIPN ) is inconclusive.
PURPOSE : Whether vitamin C is a protective factor for age-related cataract remains unclear.
PURPOSE : White matter development during childhood and adolescence is characterised by increasing white matter coherence and organisation.
PURPOSE : With its population rapidly aging , China needs prompt action to facilitate the middle-aged and senior citizens ' utilization of health care.
PURPOSE : With the aging of society in developed countries and advances in surgical technology in recent years , surgery is increasing in elderly patients.
PURPOSE : Worldwide , the most frequent cause of visual impairment is uncorrected refractive error.
PURPOSE : X-linked retinoschisis ( XLRS ) is one of the most common causes of macular degeneration in young men.
PURPOSE : Zirconia-based ceramics offer strong restorations in dentistry , but the adhesive bond strength of resin cements to such ceramics is not optimal.
PURPOSE : ω3 and ω6 fatty acids ( FA ) may have divergent effects on the development of obesity.
Purposive sampling was used to select the participants and continued until saturation.
Purposive sampling was utilized to conduct a cross-sectional , descriptive , and correlational design study.
Purposive sampling yielded @number@ elderly women who were in sexual relationships.
Purpuras , infections , and infestations may be present as well.
Pursuant to that concept , the evolution of a hypothetical , genome-based aging program called phenoptosis was proposed.
Pursuing these strategies would realise the AJA's potential as a vehicle for promoting the exchange of multidisciplinary knowledge on ageing.
Pursuit of such connections has generated a robust literature embracing a broad swath of chemical classes.
Putative biological mechanisms may include accumulated de novo mutations and alterations in epigenetic regulations with aging in spermatogenesis.
Putative causes of pruritus are numerous and patients ' quality of life can be greatly reduced.
Putative functional analysis of FCP-induced differential proteins signified an association of altered proteins in stress-related molecular and biochemical pathways of the model worm.
Putative risks include edema and worsening of sleep apnea.
Putative somatic variation between the 40-year-old twins was not confirmed in the validation phase.
Putative symptoms and comorbidities were assessed for serum testosterone-dependent prevalence change , independent of age.
Put together , the evidence supporting early aging in schizophrenia is compelling and this requires further systematic studies.
PVA and best-corrected visual acuity were normal ( ≥20 / 30 ) in @number@ ( @percent@ ) and @number@ participants ( @percent@ ) , respectively.
PVA differed ( ≥1 line ) from BCVA in at least @number@ eye in @percent@ ( n = @number@ ) of patients.
PV , adjusted for DWMH and ICV , was age associated ( p < @number@ ) .
P-values for the trend of vitamin C and E tertiles and incident WKROA were @number@ and @number@ respectively.
P-values ≤ @number@ were considered to be significant.
P values were adjusted based on the Hochberg step-up method.
PV and V̇o2 peak decreased to @number@ and @percent@ of pre-bed rest baseline , respectively , with no differences between the treatments.
PVAT can release growth factors and inhibitors.
PVR showed no significant changes in either group.
PVWMH was found significantly more frequently and in linear correlation with aging and HTN.
PWB is considered a very important correlate of subjective well-being in people with excess weight.
PWB was good in @percent@ ( score ≥ @number@ ) and poor in @percent@ ( score < @number@ ) of the residents.
PwD and their carers were randomized to one of three conditions : CST plus carer training , CST only , or a wait list control.
PwD were administered standardized measures of cognition , quality of life , and quality of relationship with carer at baseline and the @number@ week follow-up.
PWI was positively associated with perceived community connection for men and with mental health benefit for women.
PWV adjusted for weight did not differ between groups ( P = 0.10 ) .
PWV levels were slightly lower in vitamin D deficient individuals , but the association with 25 ( OH ) D was not significant.
PWV measured in each cohort was \ "normalized \ " to account for different acquisition methods.
PWV was determined using carotid and femoral applanation tonometry ( SphygmoCor ) .
Pyogenic infections of the bony spinal column and the intervertebral discs are on a steady rise in an aging western population.
Pyogenic spondylitis can be life-threatening for elderly patients.
PYP1-5 decreased the MMP-1 protein and mRNA levels , and increased the TIMP-1 and TIMP-2 protein and mRNA levels.
Pyropia yezoensis ( P. yezoensis ) is a marine algae that exhibits antioxidant , anti-inflammatory , antitumor and anti-aging activities.
Pyruvate therapy is a promising approach for the treatment of mitochondrial diseases.
PZ thickness had a significant negative correlation with PCAR ( P < @number@ ) and TZ volume ( P < @number@ ) .
P-ΔNp63α protein was further shown to interact with the Rpn13 protein leading to a proteasome-dependent degradation of p-ΔNp63α and thereby protecting LKB1 from the degradation.
QALYs were estimated up to follow-up ( @date@ ) .
QC20 was more toxic than Deflex and SC Cold Cure ( p < @number@ ) .
QCT shows high precision for the measurement of BMD in the mandible.
QDMR can also measure the sample specificity of each DMR.
QDMR was applied to synthetic methylation patterns and methylation profiles detected by methylated DNA immunoprecipitation microarray ( MeDIP-chip ) in human tissues / cells.
QF %MVIC was the sole predictor of total STS task times , as those who required the highest quadriceps efforts had the shortest task times.
Q has been associated with the prevention of cholesterol oxidation and several aging-related diseases.
QIAGEN's IDplex Plus kit targets the same loci , but the PCR cycling time is shorter by about 90min.
QIAN model is highly adaptable to other cultural and ethnic groups in multicultural societies around the globe.
Qigong improved scores in UPDRS-III and decreased incidences of multiple non-motor symptoms and depression.
QI knowledge , attitudes , and behaviors were assessed before and after the improvement project.
QIV is also expected to be a cost-effective alternative option to TIV.
QOL , a binary measure , was created by dichotomizing a 5-point Likert-scaled global assessment.
QoL-AD acceptability , reliability , and construct validity were analyzed.
QoL and HRQoL were measured using a visual analogue scale developed by the Korean Labor Institute that bears similarity to the EQ-VAS.
QoL and survival rates increased as a function of better medication adherence.
QOL is a potential primary research endpoint ; multicenter international studies are needed , as are web-based tools that work across cultures.
QoL , ranging from @number@ to @number@ was assessed with the WHOQOL-AGE.
QOL was assessed by the Functional Assessment of Cancer Treatment-Lung ( FACT-L ) Chinese version @number@ questionnaire.
QoL was assessed with the EORTC QLQ-C30.
QOL was measured using the mental and physical component scores of the SF-12 ( SF-36.org ) .
QoL was measured using the Older People's Quality of Life Questionnaire.
Q-PCR analyses show significantly lower expression levels for seven respiratory complex genes encoded by mtDNA.
QPCR analysis confirmed upregulation of this unique non-coding RNA in mutant testis.
Q-switched Nd : YAG laser was allocated to one half of the face , and Er : YAG micropeel to the other half.
QTc using a cut-off > 440ms in contingency table analysis revealed no significant differences across UCP2 I / D genotypes.
Quad processes AC and D predicted D2-scores of the content-specific IAT.
Quadratic deviation of the rate of ageing from the true value in estimated by imitation modeling techniques.
Quadriceps femoris voluntary and stimulated maximal force and rate of force development were evaluated using the interpolated twitch technique.
Quadriceps intraMF fraction but not area predicted self-reported disability.
Quadriceps strength did not change ( ±2% ; P = @number@ ) .
Quadriceps strength is a significant predictor of incident falls over three years amongst community-dwelling older women at high risk of fracture.
Quadriceps strength mediated relationships between certain nerve impairments and mobility disability , although most remained significant.
Quadriceps strength tests may be an acceptable alternative to gait speed for geriatric assessments of falls risk.
Quadriceps strength was lower in ROA group but the area was not different.
Qualifying arrhythmias were classified by a blinded adjudicating committee.
Qualitative 18F-florbetapir PET imaging was positive in @number@ participants ( @percent@ ) .
Qualitative analyses suggested that respondents perceived significant problems related to affordability and accountability within the current LTC insurance industry.
Qualitative analysis demonstrated a remarkable parallel organisation of vimentin-immunoreactive processes during the infant / prepubertal and adult periods.
Qualitative analysis of journals in a death and dying class reveals three transformative themes : awareness of others , questioning , and comfort.
Qualitative analysis of SMCs can inform the earliest clinical manifestations of Alzheimer's disease.
Qualitative analysis was conducted consistent with the grounded theory approach.
Qualitative and quantitative data were analyzed separately and a mixed methods matrix was used to interpret and integrate the findings.
Qualitative approaches aimed at studying the caregiver / patient relationship , and situations leading to breakdown of the caregiver relationship will be also undertaken.
Qualitative assessment at @number@ months not only facilitates diagnosis of major developmental disorders but is also a good predictor of delayed motor development in children.
Qualitative assessment results were very good in healthy children and decreased with worsening neurological diagnoses.
Qualitative changes in skeletal muscle , such as increased intramuscular fat , also occur as one ages.
Qualitative comparative analysis by operating Boolean algebra and drawing Venn diagrams was used to visualize our findings.
Qualitative data analysis was performed using grounded theory methodology.
Qualitative data collected from MAHT members were the basis for case studies illustrating the progression of cases through the public sector.
Qualitative data on participant's confidence levels were also collected.
Qualitative data supported these results.
Qualitative data was analysed using thematic analysis.
Qualitative data were analysed using an inductive , thematic approach.
Qualitative data were analyzed using Dedoose software.
Qualitative data were analyzed using NVivo software and were categorized using coding and grounded theory techniques.
Qualitative data were collected from @number@ people who were purposively selected.
Qualitative data were collected using in-person narrative interviews with @number@ individuals and a second photo elicitation interview with @number@ of these persons.
Qualitative data were collected using semi-structured interviews with @number@ Chinese elders who were aged between @number@ and @number@ using purposive and theoretical sampling approaches.
Qualitative data were collected via focus groups with aged-out foster youth ( N = 15 ) .
Qualitative data were reviewed , categorized on the basis of theme , and tabulated for frequency.
Qualitative data were strongly supportive , valuing and accepting of the ACP role.
Qualitative examination revealed more anteriorly placed glottal gaps in the geriatric females.
Qualitative findings revealed that the prime reason for non-use of the internet was related to literacy and level of education due to historical background.
Qualitative findings were extracted and coded / categorized.
Qualitative in-depth interviews explored the challenges confronting women during this period.
Qualitative interviews were coded by two raters and content analyses were conducted using NVivo @number@ software.
Qualitative interviews with @number@ ADNA VD-HCBS personnel across the country were transcribed , coded , and analyzed.
Qualitative investigation revealed discrepancies in classification of adherence and non-adherence based on quantitative analysis and interviews.
Qualitative methods including participant observation , non-participant observation , in-depth interviews , and mobile ethnography were used to collect data.
Qualitative methods may help capture these lay meanings of health.
Qualitative methods were used to identify the concepts most important to patients who received aesthetic facial procedures.
Qualitative nanoleakage analysis was performed from a central stick of each restored tooth.
Qualitative observational techniques were used to understand how eye contact can implicate communication.
Qualitative-quantitative non parametric multivariate analysis has been used as statistical test.
Qualitative research offers important insights into the subjectivity , complexity , and relationality of care.
Qualitative results suggested shared stressors and bereavement-related distress as potential mechanisms for heightened reactivity to interpersonal suffering.
Qualitative results were analyzed using inductive content analysis.
Qualitative studies ( four ) showed a benefit of the use of technologies to foster social participation in people with dementia.
Qualities were measured using the WHOQOL-BREF and WHOQOL-OLD.
Quality appraisal distinguished two studies as high quality investigations while three with low quality.
Quality assessment and data extraction were carried out by two reviewers independently.
Quality assessment was carried out by using criteria from the Cochrane Collaboration and the GRADE working group.
Quality assessment was conducted using the Jadad and the Downs and Black tools.
Quality attributes were evaluated at @number@ @number@ and @number@ days.
Quality-compromised oocytes are correlated with infertility , developmental disorders , reduced blastocyst cell number and embryo loss in which mitochondrial dysfunctions play a significant role.
Quality control for damaged mitochondria entails cellular digestion by mitophagy , a specialized kind of autophagy.
Quality control pathways play an important role in DNA repair and cellular DDR pathways.
Quality CPGs were analyzed through organizational template analysis using illness domains described by the \ "Canadian Hospice Palliative Care Association Model. \ "
Quality Function Deployment ( QFD ) is then utilized to find key factors to improve the implementation of the top ten tools.
Quality improvement ( QI ) initiatives are critical in the care of older adults who are more vulnerable to substandard care.
Quality Indicators ( QIs ) of a sufficient methodological level are a prerequisite to monitor , compare , and improve care quality.
Quality of cf-DNA was analysed with a DNA Chip assay.
Quality of decision-making was negatively correlated with the score on the impulsive / careless problem-solving subscale.
Quality of life for a majority of older Swedes is high.
Quality of life in MM is influenced by disease-related symptoms , treatment-related toxicity and treatment response.
Quality of life in our society depends crucially on healthy aging , a hallmark of which is the graying hair follicle.
Quality-of-life-limiting diseases such as arthritis and cataract are more prevalent , potentially through more diagnosing of milder forms in otherwise healthy and active individuals.
Quality of life needs to be measured with formal instruments after iliac artery endovascular treatment , especially to determine long term outcomes.
Quality of life of scientists of advanced age in comparison with other pensioners has been analyzed.
Quality of life ( QOL ) has been defined in many ways , and these definitions usually emphasize happiness and satisfaction with life.
Quality of life ( QoL ) of long-term care ( LTC ) facility residents is an important outcome of care.
Quality of life ( QOL ) was assessed at baseline and @number@ months after starting chemotherapy or at the end of chemotherapy.
Quality of life remains an important aspect of therapy.
Quality-of-life scores were reduced for all subjects.
Quality of life score was improved in all treatment groups.
Quality of life was assessed using the EuroQol-5D test.
Quality of life was assessed using the visual analogue scale of the quality of life test.
Quality of life was assessed using the WHO Quality of Life-BREF ; activities of daily living were measured using the Barthel-Index ( BI ) .
Quality of life was determined with the European Organization of Research and Treatment in Cancer questionnaire , reflecting both several function scales and symptom severity.
Quality of life was measured with the EuroQol-5D-3L ( EQ-5D-3L ) EQ-Visual Analog Scale and the Satisfaction With Your Life Scale.
Quality of RNA was consistent between laboratories and met the criteria requested for quantification of BCR-ABL1 transcripts.
Quality of sperm chromatin condensation was assessed by toluidine blue , aniline blue and chromomycin A3 staining.
Quality of standing balance might be more sensitive to detect age-related differences.
Quality of these studies was rated.
Quality ratings were negatively associated with for-profit , chain , or multi-ownership status.
Quality standards have been successfully applied in a range of healthcare settings which allow services to implement improvements where necessary.
Quality was assessed using the Joanna Briggs Institute checklists.
Quality was scored according to the quality assessment for cohort studies of the Dutch Cochrane Institute.
Quantification analysis revealed striatal VMAT2 density of anterior putamen > posterior putamen > caudate nucleus.
Quantification and distribution of the NRC obtained by 3T MRI was well correlated with pathological findings reported previously and clinical parameters in this study.
Quantification of muscle protein synthesis ( MPS ) remains a cornerstone for understanding the control of muscle mass.
Quantification of serum Klotho after @number@ years from transplantation demonstrated significant lower levels in DGF patients.
Quantification of structural changes in the human brain is important to elicit resemblances and differences between pathological and normal aging.
Quantification was performed by extraction and analysis using HPLC with fluorescence detection.
Quantifying an older adult's resilience in an early stage would aid complex decision-making in health care.
Quantifying human weight and height dynamics due to growth , aging , and energy balance can inform clinical practice and policy analysis.
Quantifying the different facets of mobility has the potential to facilitate the clinical characterization and understanding the biologic basis for impaired mobility in older adults.
Quantifying the extent and identity of epigenetic changes in the aging process is therefore potentially important for understanding longevity and age-related diseases.
Quantifying the human vertebral geometry is important for accurate medical procedures.
Quantifying this morbidity at the population level can help inform healthcare delivery requirements for this complex population.
Quantile regression avoids common distributional assumptions on cognitive outcomes and allows the covariate effects and the change-point to vary for different quantiles of the response.
Quantile regression was used to estimate the 95th percentile for globally sclerotic glomeruli as the upper reference limit.
Quantitative analyses of extracted data were conducted using meta-analysis where possible to determine incidence of delirium and prognostic factors.
Quantitative analyses were performed on a high-performance liquid chromatography-coupled electrospray ionization tandem mass spectrometer.
Quantitative analysis was performed by two observers with manually defined regions of interest , on the most homogeneous portion of the right liver lobe.
Quantitative and descriptive analysis of @number@ randomly selected publicly-open ECtHR cases dealing with elder-rights between the years 2000-2010.
Quantitative and qualitative data were collected by a survey of @number@ older ICT users ( aged ≥50 years ) between @number@ and @number@
Quantitative assessment of collagen images revealed statistically significant ( P < @number@ ) improvement of collagen content at a time point of two weeks.
Quantitative assessment of sperm PATE1 protein was performed on sperm from @number@ young fathers , @number@ aged fathers and @number@ young asthenozoospermia patients.
Quantitative assessments found high levels of morbidity and friend-centered support networks.
Quantitative comparison was conducted in terms of BMD and other morphometric indices.
Quantitative Computed Tomography ( QCT ) was used to investigate age-related changes in trabecular bones of the mandible.
Quantitative data collected on @number@ cases involving adults ages 60 + identified steps in this process.
Quantitative data ( questionnaire ) measuring the RN work environment were also collected to augment qualitative data.
Quantitative data support these observations : the size of small and medium objects of skin relief decreases with age while large objects are becoming larger.
Quantitative data triangulated qualitative findings.
Quantitative data were analysed using PASW including bivariate and multivariate analyses.
Quantitative data were collected from @number@ participants.
Quantitative data were obtained by fluorescence microscopy by counting and measuring and by the use of stereology.
Quantitative data will be analyzed using descriptive and inferential statistics and qualitative data will be analyzed through content analysis.
Quantitative fiber tracking was performed of fornix , cingulum , and the parahippocampal gyrus.
Quantitative gait analysis allows not only the early detection of gait deficits and fall risk , but also of cognitive deficits.
Quantitative gait analysis can provide early detection of gait and cognitive impairments as well as fall risk.
Quantitative gait analysis should be viewed as a clinical tool to aid diagnoses and treatment planning.
Quantitative-gated myocardial perfusion single-photon emission computed tomography ( SPECT ) is widely used to measure LV functional parameters.
Quantitative genetic procedures were used to estimate heritability of neopterin.
Quantitative histochemical analysis revealed a collagen-rich annulus and a proteoglycan-rich cusp at all stages.
Quantitative magnetic resonance angiography was used to obtain volume flow and diameter , and subsequently to calculate MWSS via the Hagen-Poiseuille equation.
Quantitative magnetic resonance ( MR ) imaging allows visualization of age-related changes in the normal human brain from functional , biochemical , and morphologic perspectives.
Quantitative methods were employed to investigate the relationship between the Distress Thermometer rating , depression scores and problems or needs selected on the DTE.
Quantitative methylation-specific real-time PCR was also conducted for @number@ CpG island promoters ( MINT25 , MYO3A , and SOX11 ) .
Quantitative MRI maps were obtained using relaxation time mapping methods.
Quantitative MRI markers can be derived from diffusion weighted and iron-sensitive imaging or volumetry.
Quantitative MRI ( qMRI ) techniques allow the assessment of changes in brain tissue composition.
Quantitative neuropathological analysis of plaques , tangles , and Lewy bodies were carried out in the same regions.
Quantitative NS mRNA measurements showed that MSCs from two sources exhibit a strong nucleostemin expression similar to embryonic stem cells.
Quantitative observational studies were included to investigate the work ability and the effect of aging.
Quantitative PCR ( qPCR ) analysis confirmed the deletion , which was present in @number@ affected individuals.
Quantitative PCR was performed to confirm the changes in the expression of miRNAs in the different age groups.
Quantitative PCR was used to measure telomere length in genomic DNA isolated from peripheral blood samples.
Quantitative polymerase chain reaction also identified increased IFNα and IFNβ expression in human pre-frontal cortex from AD patients.
Quantitative polymerase chain reaction analyses were used to study adenosine receptor expression in rat and human detrusor specimens.
Quantitative polymerase chain reaction and Western blot experiments demonstrated diminished SYNJ1 messenger RNA and protein.
Quantitative polymerase chain reaction ( qPCR ) was performed after the heat shock to determine gene expression levels relative to the reference temperature.
Quantitative proteomics employing mass spectrometry is an indispensable tool in life science research.
Quantitative real-time PCR of selected genes verified the proteomic data.
Quantitative real-time polymerase chain reaction analyses for CMV and EBV were carried out and viral loads were determined.
Quantitative relaxometry measures were negatively associated with levels of CSF biomarkers across brain white matter and in areas preferentially affected in AD.
Quantitative results showed a decrease in the collagen content with increasing age of the subjects.
Quantitative results showed that a small number of variables have a significant influence in the pre-implementation stage.
Quantitative RT-PCR experiments validated expression change for a majority of the @number@ genes that were examined.
Quantitative stereological analysis of post mortem tissue may help understand the influence of age or disease on the number of human testicular cells.
Quantitative trait loci mapping confirmed linkage disequilibrium.
Quantitative transverse relaxation rates in normal aging brain are essential to investigate pathologies associated with iron accumulation and tissue degeneration.
Quantitative validation demonstrates that our proposed method generates registrations that better preserve the consistency of anatomical structures over time.
Quantity and pH value of saliva were determined in the laboratory.
Quarterly SCD rates for men decreased by @number@.34 / 100 , 000 population ( P < @number@ ) .
Quartile comparisons revealed that age-related declines in DHEA were linear , curvilinear , or sigmoidal , depending on the summary parameter of interest.
Quartile improvement scale ( 0-4 ) and Fitzpatrick wrinkle scores ( 1-9 ) were used for the assessments.
Quercetin , a natural polyphenolic flavonoid that has been widely investigated for its other health benefits , may act as an inducer of SirT1.
Quercetin is metabolized to quercetin glucuronates such as quercetin-3-O-glucuronide ( Q3GA ) , primarily detected in the plasma and the brain.
Quercetin ( Qe ) plays an important role in inflammation , antibacterial , anticancer , and aging.
Question 31 : How does aging process inhibit the formation of sarcoma ?
Question 32 : Is intratumoral morphological heterogeneity the consequence of tumor genomic instability or the cause of aggressive tumor behavior ?
Question 33 : How to pre-surgically differentiate irradiation-induced ulceration from cancerous ulceration ?
Question 35 : Can an Epstein-Barr virus vaccine be developed to reduce the incidence of EBV-related malignancies ?
Question 36 : What is the unique feature in sarcoma vasculature that causes the intrinsic resistance of sarcoma against anti-angiogenic therapy ?
Question 37 : How many ways can sarcoma cells protect themselves from the attacks of cytotoxic drugs ?
Question 38 : How stable does the tumor heterogeneity remain along with cytotoxic chemotherapy ?
Question 39 : How to generate a prognostic classifier for diffuse low-grade gliomas by integrating genetic and epigenetic signatures with histological features ?
QUESTION : My patient received @number@ units of botulinum toxin type A ( BTX-A ) for facial lines.
Questionnaire data on health history , medication use , risk factors , and quality of life were available for @number@ participants.
Questionnaire information about behaviors , environmental factors , and medical history was also collected.
Questionnaire responses were analyzed using multilevel modeling and path analysis.
Questionnaires about their dementia care competency and referral patterns were completed before and @number@ months after the training intervention.
Questionnaires assessing health status ( SF-36 , EQ-5D , EQ-VAS ) and depressive symptoms ( CES-D ) were filled out.
Questionnaire scale scores were normally distributed.
Questionnaires compiled by an expert group and filled in by @number@ physicians ( @number@ men and @number@ women ) were analysed.
Questionnaires concerning demographics and psychological characteristics were also collected prior to the overnight recording and entered into multivariable models.
Questionnaires to assess PAP usability are unavailable ; therefore , we developed the Usability of Sleep Apnea Equipment-Positive Airway Pressure ( USE-PAP ) questionnaire.
Questionnaires used in this study are General geriatric assessment questionnaire and Mini nutritional status.
Questionnaires were administered to assess driving habits and functional assessments to assess driving-related function.
Questionnaires were completed by nurses and volunteers in regards to their views and experiences with the program.
Questionnaires were issued in @number@ covering @number@ districts in Beijing.
Questionnaires were obtained and standardized photographs were taken by professional photographers.
Questionnaires were returned via e-mail.
Questionnaires were used during the in-person semistructured interviews , which were conducted in the wards.
Questionnaire was used to collect the information about gender , age and health status.
Questions covering physical , psychological and social factors that may have an impact on nutritional status were also posed.
Questions explored perceptions of facilitators and barriers to culture change.
Questions include : What is the best structure to measure ?
Questions of forms of application , biological availability , reliability of the rendered anti-aging effects are considered.
Questions of mutual relations of various diseases of cardiovascular system on clinical , pathogenetic , pathomorphological , biochemical levels are considered.
Questions of the KOP-Q were completed online.
Questions pertaining to self-rated competency , knowledge and attitudes used a five-point Likert scale.
Questions regarding internet access and use of electronic media to obtain health information and coordinate care were distributed.
Questions related to the burden of maintenance therapy showed the lowest improvements in score.
Questions remain as to the role of combination antifibrotic therapy as a future treatment option.
Questions to be addressed include : How this microbial ecosystems in and around humans beings coevolve and stabilize during human development and aging ?
Questions were asked regarding antibiotic selection , probiotic use , and approach to a patient scenario of diarrhea after antibiotic use.
QUESTIONS : What happens when elders choose to live together in a community in which they consciously address aging collectively ?
QUESTION : What is the free-living physical activity of community-dwelling people with stroke compared with that of age-matched healthy controls ?
Quickly biodegradable or resorbable agents may induce severe complications , but they will normally disappear spontaneously in a few months.
Quickly forward-rotation shift workers considered their working time less harmful compared with slower backward-rotation shift workers.
Quick release of a digit led to force changes in other digits of the hand , likely due to inertial hand properties.
Quiescence should therefore not contribute to cellular aging but rather extend lifespan.
Quiescent NHFs cultured for a long duration ( 30-60 days ) lose their capacity to repopulate.
Quiescent NHFs overexpressing a dominant-negative mutant form of MnSOD failed to extend CLS.
Quiescent stage of the liver is supported by several tumor suppressor proteins including p53 , Rb and C / EBPα.
Quiet standing and walking are generally considered to be an automatic process regulated by sensory feedback.
\ "Quiet standing \ " is standing without intended movement.
Quintiles of the modified arch index and center of pressure excursion index from plantar pressure scans were used to create foot posture and function subgroups.
Quitting smoking and reducing intake of sugar-sweetened beverages and meat and meat products are mandatory.
QUS at the calcaneus was measured in all subjects and blood was taken for genetic analysis.
R1 reductions and R2 increases were observed to a smaller extent in overlapping occipito-parietal white matter regions.
R2 and R2 ' increased with age in deep GM structures except for the thalamus.
R2 and R2 ' showed a distinct dependency on fiber orientation in exemplary WM regions.
R2 coefficient was used to measure the reliability of each item.
R2 decreased with age for the majority of ROIs , but increased for putamen , head of caudate nucleus and nucleus accumbens.
RAA can be a useful tool to simulate worst-case in vivo damage resulting from chronic electrode implantation , simplifying the device development lifecycle.
Rab1A expression is associated with malignant phenotypes in several human tumors ; however , the role of Rab1A in lung cancer is still unclear.
Rab1A knockdown had no effect on mTOR signaling or cell growth.
Rab1B has recently been reported to be involved in human cancer , but the role of Rab1B in colorectal cancer ( CRC ) remains unclear.
RAB7L1 is an important gene involved in one of the important neurological pathways , located in PARK16 locus.
Rac1 and NMDA receptors are thought to be involved in hippocampal neurogenesis , which is induced by learning.
Race and current socioeconomic status ( SES ) are associated with sleep.
Race and gender may be important considerations for recognizing alcohol related problems in Black and White young adults.
Race and sex were not statistically significant independent predictors of risk acceptance.
Race , but not sex , seems to be an important consideration in proper central eyebrow position.
Racecadotril is also more cost effective than loperamide.
Race / ethnicity appeared to modify the association between involvement in clubs , associations , or help groups and obesity.
Race / ethnicity differences varied across groups and pain assessment type.
Racemized Asx ( aspartate and asparagine ) was significantly enriched in AKU cartilage compared with in OA cartilage.
Race performance was standardised using the World Masters Association Age Grading Performance Tables.
Race , sex , intraocular pressure , and gonioscopy score were not correlated with any TM parameters.
Race times were slower in the mountain compared to the city marathon.
Race was based on self-report.
Race was shown to be a very significant factor determining susceptibility to NIHL and ARHL.
RACF staff stated the major barrier to assessment of BPSD was lack of time.
Racial , age and gender disparities in mental health care are coupled with a general delay in diagnosis and treatment.
Racial and ethnic differences in MBT use were identified , as was a significant negative relationship between MBT use and depression severity.
Racial and ethnic disparities in health care access and quality are well documented for some minority groups.
Racial and ethnic health disparities in reproductive medicine exist across the life span and are costly and burdensome to our healthcare system.
Racial differences in support to each generation in the family remain unclear , however.
Racial differences were not significant for WMH ( p = 0.062 ) or GMA ( p = 0.4 ) .
Racial disparities in cessation are wider at older ages.
Racial disparities in cognitive outcomes may be partly explained by differences in locus of control.
Racial disparity was seen in the all-cause mortality as Mexican Americans with chronic HCV had approximately seven times higher mortality rate than HCV-negative individuals.
Racial / ethnic differences remained significant only for nHB compared to nHW.
Racial / ethnic mortality inequalities among dementia patients mostly paralleled mortality inequalities among people without dementia.
RACK1 can shuttle proteins to their sites of action , facilitate cross-talk among distinct signaling pathways or recruit other signaling proteins into the complexes.
RACK1 pseudosubstrate alone induced IL-6 , IL-8 , and CD86 expression in both young and old donors , and IFN-γ in old donors.
RACP can shorten the operation duration and facilitate precise graft localization / deployment.
RAD001 enhanced the response to the influenza vaccine by about @percent@ at doses that were relatively well tolerated.
Rad26p is a SWI / SNF-like ATPase in yeast , and is conserved among eukaryotes.
RAD9 is another protein critical for the response of cells to DNA damage , and can also selectively regulate gene transcription.
Radial strain ( RS ) normal mean values varied from @number@ to @number@ ( mean , @number@ @percent@ CI , @number@ to @number@ ) .
Radiation exposure leads to higher cancer rates among orthopedic and spine surgeons and patients.
Radiation is used widely in health , academic area , and industry for producing electricity.
Radiation related effects in children and adults limit the delivery of effective radiation doses and result in long-term morbidity affecting function and quality of life.
Radiation therapy provides significant pain relief of symptomatic bone metastases , but appropriate radiotherapy scheduled is needed in order to get significant response to treatment.
Radiation therapy remains a promising modality for curative treatment of localized prostate cancer , but dose-limiting toxicities significantly limit its effectiveness.
Radiation time per level and surgeon's exposure were calculated.
Radical scavenging activity was determined by the ability of the plant extracts to scavenge the ABTS• + radical.
Radiochemical and HPLC techniques had intra- and inter-assay coefficients of variation ( CVs ) below @percent@.
Radiofrequency ( RF ) and intense focused ultrasound ( IFUS ) are increasingly used to address skin laxity of the face and neck.
Radiofrequency ( RF ) and light-emitting diodes ( LEDs ) are widely used , clinically proven technologies for skin rejuvenation.
Radiofrequency ( RF ) devices are constantly evolving and consequently adding multiple indications for their use.
Radiofrequency ( RF ) is a method that uses electric current for heating layers of the skin.
Radiofrequency ( RF ) treatments are traditionally titrated to be nonablative and are optimal for those wishing to avoid recovery time.
Radiographically , spinous process impingement leads to reactive sclerosis , enlargement , flattening , and remodeling of the involved vertebral spines.
Radiographic evaluations consisted of weight-bearing knee anteroposterior radiographs and @number@.5-T MRI scans.
Radiographic evaluations of scapular notching , tuberosity osteolysis , and periprosthetic radiolucent lines were done as well.
Radiographic examination revealed a prickly or flakey structure and bone loss on the affected side of the involved tooth.
Radiographic examination showed similar results.
Radiographic exams were performed on @number@ skulls ( one skull was not analysed radiographically because of extensive destruction ) .
Radiographic exam was performed in the skulls with metopism to verify the presence or absence of the frontal sinus.
Radiographic features of temporal bone involvement are reviewed and illustrated.
Radiographic studies were sought to corroborate their responses.
Radiographs and microCT showed increased calcified callus tissue and enhanced bone healing in young compared to aged mice.
Radiographs were obtained in standing , supine , and sitting ( 30° , 60° , and 90° ) positions respectively.
Radiological examination was obtained for each patient to assess the height of intervertebral space , postoperative intervertebral fusion conditions and the degeneration of adjacent segments.
Radiological features were the same as those usually described in younger patients.
Radiologic data were evaluated from the latest radiographs , and comorbidity data from patient records.
Radiologic findings showed global or predominant vermian cerebellar atrophy in all patients.
Radiologists measured the aorta-sacral promontory distance on sagittal acquisition.
Radiotherapy is widely used to treat cancer because it has the advantage of physically and functionally conserving the affected organ.
Radiotracer-based functional imaging provides a sensitive means of recognizing and characterizing the regional changes in brain metabolism and receptor binding associated with cognitive disorders.
Radius length-width correlation for the isolated radii was r = 0.621 ( adj.
Radius measures were comparable between athlete and control groups at all ages.
RaD mediated the relationship between age and task switching performance.
RAGE is expressed on multiple cell types linked to tissue perturbation in these settings.
RAGE is important in the development of neurodegenerative diseases.
RAGE ( Receptor for Advanced Glycation End Products ) mediates some of the effects of AGEs.
RAGE represents an important factor in innate immunity against pathogens , but it also interacts with endogenous ligands , resulting in chronic inflammation.
RAGE signaling has been implicated in multiple human illnesses , including diabetes , atherosclerosis , arthritis , Alzheimer's disease , atherosclerosis and aging associated diseases.
RA group status was associated with all bone parameters except cortical CSA.
Raised creatinemia in ELBW neonates reflects immaturity ( GA ) and morbidity ( ventilation , Apgar ) .
Raised HADS was associated with higher number of new antidepressant prescriptions which has significant resource implications.
Raised systolic blood pressure and diabetes were found to be key risk factors for both ischemic ( IS ) and hemorrhagic ( HS ) stroke.
Raising an adolescent or adult child with a developmental disability confers exceptional caregiving challenges on parents.
Raising awareness of all this will result in the patient benefiting from the recent improvements in treatments.
Raising physicians ' awareness of polypharmacy may help to ensure safe , effective and appropriate use of medication in the elderly.
Raising the awareness of elderly people and their families regarding the need to improve and maintain nutrition would be beneficial.
Raising the cutoff score to ≥2 , the sensitivity dropped to @number@ whereas the specificity rose to @number@
RA is the prototypic chronic inflammatory disease , characterized by progressive articular cartilage and bone destruction.
RAIU was @time@ ± @number@ for @number@ to 29-year-olds and @number@ ± @number@ for @number@ to @number@ year-olds ( P = @number@ ) .
Raloxifene , a second generation SERM , was used to prevent postmenopausal osteoporosis.
Raltegravir ( RAL ) is an HIV-1 integrase inhibitor that may have limited metabolic effects.
Raman and biometric data were then submitted to a partial least square ( PLS ) -based data processing.
Raman spectra were collected from both untreated and CO2 laser-treated samples using a @number@ nm diode laser.
Raman spectroscopy could confer great patient benefit with early , rapid and accurate diagnosis.
Raman spectroscopy has been used to evaluate alterations to bone composition associated with aging , disease , or injury.
Raman spectroscopy is based on the interaction of photons with the target material producing a highly detailed biochemical ' fingerprint ' of the sample.
RA measurements were generated for the @number@ × @number@ mm ( @number@ ) retinal area.
RAMPs are required for the surface delivery of CLR and the determination of its phenotype.
RAND-36 scales associated with mental health were not affected by midlife BP.
Random coefficient models estimated person-specific slopes of decline in episodic memory and nonepisodic cognition.
' Random Digit Generation' , ' Brooks ' Spatial Memory' , and ' Counting Backward' ) involving different working memory components were examined.
Random-effect meta-analysis was performed to calculate a pooled effect size ( ES ) and @percent@ CIs.
Random effect models were used to assess the association between hypovitaminosis D and diabetes at follow-up.
Random-effect regression analysis shows that son's marital status has strong effects on financial support to and coresidence with parents.
Random-effects and hierarchical summary receiver operating characteristic model meta-analyses were used to analyze the data.
Random-effects linear regression was used to model factors affecting speed.
Random-effects meta-analyses of primary observational studies will be conducted where appropriate.
Random effects meta-analysis and meta-regression analyses were conducted.
Random-effects meta-analysis was used to calculate combined effect estimates.
Random effects meta-regression showed that OR for all-cause mortality with SPPB values 7-9 was higher in the younger population , diabetics , and men.
Random effects mixture models characterized latent profiles of residual decline in global cognition.
Random-effects modeling controlled for baseline stage of change for all behaviors of interest in all groups.
Random effects regression analyses were used to examine the patterns in item scores associated with ageing.
Random intercept generalized least squares ( GLS ) regression models were used to determine change in sedentary behaviour with seven waves of repeated measures.
Random-intercept multilevel regression models were used on pooled data from the six countries.
Randomised clinical trials which focus on elderly mood disorders are not very common and the majority of them focus on pharmacological treatment of major depression.
Randomised controlled trials and large cohort studies were sought ; other studies were used when these were not available.
Randomised controlled trials are currently underway , and will hopefully provide us with good evidence for or against the conservative treat-ment of cSDH.
Randomised controlled trials are needed to confirm the relationship between dairy intake and cognition.
Randomised controlled trials were included that evaluated pharmacist-led interventions compared with usual care , with unplanned admissions or readmissions as an outcome.
Randomised trials demonstrated that early hemicraniectomy reduces mortality from about @percent@ to @percent@ without increasing the risk of being very severely disabled.
Random Item Generation tasks ( RIG ) are commonly used to assess high cognitive abilities such as inhibition or sustained attention.
Randomization was balanced.
Randomization was challenging due to community concerns about assigning women to a control group.
Randomization was stratified by previous opioid use ( naïve or experienced ) .
Randomization was stratified depending on eligibility for each group.
Randomization was stratified for age , function , and symptom severity ( Victorian Institute of Sports Assessment-Achilles [ VISA-A ] ) .
Randomization will take place at the individual patient level.
Randomized and observational studies have shown that OM provides effective BP control across the @number@ h dosing interval in the elderly.
Randomized clinical trials , longitudinal studies , case series and case reports were included.
Randomized clinical trials were mainly available for therapeutic decisions , and new diagnostic procedures have been introduced into clinical practice in the past decade.
Randomized controlled studies comparing different designs and assessing outcomes are virtually non-existent.
Randomized controlled trial evidence that vascular anatomy should inform the choice between CAS and carotid endarterectomy ( CEA ) has been lacking.
Randomized controlled trials and mechanistic clarification are required in the future.
Randomized controlled trials are needed to assess the efficacy and tolerability of subcutaneous antibiotic administration given its frequent use in an aging population.
Randomized controlled trials are required to determine the true causal nature of any such association.
Randomized controlled trials concerning the effects of treatment of depression on mortality are needed to clarify the causal pathways.
Randomized controlled trials of older adults ( ≥65 years of age ) that examine geriatrician-led CGAs compared to any intervention will be included.
Randomized controlled trials ( RCTs ) emphasize the average or overall effect of a treatment ( ATE ) on the primary endpoint.
Randomized controlled trials ( RCTs ) of acupuncture plus herbals versus treatment with western drugs for AD were retrieved from @number@ databases.
Randomized controlled trials report a clear benefit of increased dietary protein on lean mass gain and leg strength , particularly when combined with resistance exercise.
Randomized controlled trials to determine health benefits and risks from long-term weight management in obese elderly are necessary.
Randomized nursing home assignment to intervention or comparison group.
Randomized , placebo-controlled trials that involved older adults supplemented with Cr and included RT regimens ( > 6 wk ) were included.
Randomized trials of sedentary behavior reduction in overweight and obese older adults , most of whom have multiple chronic conditions , may be promising.
Randomized trials of α-tocopherol supplements on cognitive decline are negative , whereas studies of dietary tocopherols have shown benefit.
Randomized trials should consider the contribution of γ-tocopherol.
Random- or fixed-effects models were conducted to obtain overall effect size per physical function measure.
Random samples were drawn from primary care lists.
Random survival forest analysis was used to rank the candidate predictors by their importance.
Rank frequency analysis shows the same two-component clonotype distribution described earlier for these repertoires.
RANKL , in turn , contributes to vascular calcification by regulating bone morphogenetic protein-2 and MGP expression , as well as bone-related proteins.
RANKL siRNA also inhibited osteoblastic differentiation and calcification.
Ranolazine is a selective inhibitor of the cardiomyocyte late inward sodium current , INaL , and features anti-ischemic , antiarrhythmic and ATP-sparing actions.
( Ranunculaceae ) have been used as a traditional remedy for treatment of inflammation and cancer.
RA oocytes also showed changes of the zona pellucida and occurrence of vacuoles after culture.
Rapalogs can prevent age-related diseases , including cancer , atherosclerosis , obesity , neurodegeneration and retinopathy and potentially rejuvenate stem cells , immunity and metabolism.
Rapamycin , a gerosuppressant , extends life span in diverse species from yeast to mammals.
Rapamycin , an autophagy inducer , reversed Nef-induced senescence and oxidative stress.
Rapamycin and adiponectin might inhibit vascular calcification through regulation of the mTOR pathway.
Rapamycin , an inhibitor of mTOR , inhibits cell senescence in vitro and increases longevity in several species.
Rapamycin , an mTOR inhibitor affects senescence through suppression of senescence-associated secretory phenotype ( SASP ) .
Rapamycin , a specific inhibitor of mTOR , has been shown to be useful in the treatment of certain diseases.
Rapamycin can decrease gero-conversion by PMA , without preventing PMA-induced arrest.
Rapamycin had only minor effects on H2O2 production and telomere length.
Rapamycin inhibits some , but not all , activities of mTOR.
Rapamycin inhibits the mTOR ( target of rapamycin ) pathway and extends lifespan in multiple species.
Rapamycin is a macrolide immunosuppressant drug , originally used as an anti-fungal agent , which is widely used in transplantation medicine to prevent organ rejection.
Rapamycin is an obvious candidate for the treatment of HGPS disease but is difficult to utilize clinically.
Rapamycin-mediated T cell blockade significantly reduced the frequency of VGF-expressing T cells.
Rapamycin regulates autophagy through inhibition of the nutrient-sensing molecule mammalian target of rapamycin ( mTOR ) .
Rapamycin slows aging and extends life span in a variety of species from worm to mammals.
Rapamycin slows organismal aging and delays age-related diseases , extending lifespan in numerous species.
Rapamycin suppressed geroconversion , maintaining quiescence instead.
Rapamycin suppressed geroconversion , whereas PMA partially counteracted the effect of rapamycin , revealing the involvement of rapamycin-insensitive gerogenic pathways.
Rapamycin transforms tissue macrophages into M1 phenotype , promoting the tumor regression.
Rapid and slow decliners had similar age , gender , and education levels at baseline.
Rapid conduction of nerve impulses requires coating of axons by myelin sheaths , which are lipid-rich and multilamellar membrane stacks.
Rapid expansion and symptomatic patients should undergo aneurysm resection regardless of size.
Rapid head growth was defined as crossing upwards through two major centile bands ( @number@ SD ) .
Rapidly evolving technologies , particularly in sensors and OMICs , will present opportunities for the field.
Rapid movement of cav-1 in response to ACh suggests its dynamic role in CSMC contraction.
Rapid , reliable , and robust detection of Salmonella in produce remains a challenge.
Rapid reviews may allow supporting their development by omitting certain components of traditional systematic reviews.
Rapid widespread adoption has outpaced a sophisticated understanding of the goals of volume rejuvenation.
Rare alleles are also likely to contribute to healthy aging and longevity.
Rare diseases are powerful windows into biological processes and can serve as models for the development of therapeutic strategies.
Rare diseases comprise the majority of chronic kidney disease ( CKD ) in children but are notoriously difficult to diagnose.
Rare events included bruising , welting , and nerve-related effects ( paresthesia and paresis ) .
Rare incidence of surface thermal effects was seen in some cases where improper technique was used.
Rarely baseline comorbidity burden appeared to be associated with outcomes in studies analyzing progression over longer follow-up periods ( > 2 years ) .
Rarely concomitant perianal abscess and fistula are treated at the same time , and often time to complete recovery is long.
Rarely , patients present severe bowel obstruction , perforation or severe bleeding.
Rarely was socioeconomic position ( SEP ) adequately accounted for.
Rare monogenic hyperchylomicronemia is caused by loss-of-function mutations in genes involved in the catabolism of triglyceride-rich lipoproteins , including the lipoprotein lipase gene , LPL.
Rare plants , except for Panax genus , which contain dammarane triterpenoids should be studied extensively.
Rarer short-duration ( < 4 hours ) forms of CDH are chronic cluster headache , chronic paroxysmal hemicrania , SUNCT , and hypnic headache.
Rare single-gene disorders cause chronic disease.
Rare TREM2 variants have been recently identified in families affected by FTD-like phenotype.
Rare variants in TREM2 were reported to be associated with significant Alzheimer's disease ( AD ) risk.
Rare variants were analyzed using the optimal unified sequence kernel association test.
Rare variation in the TREM2 gene is associated with a broad spectrum of neurodegenerative disorders including Alzheimer's disease ( AD ) .
RAS blockade reduces mtROS and enhances mitochondrial content and function.
Rasch model analyses were used to analyze the psychometric characteristics of the instrument in a sample of @number@ participants.
RAS inhibition up-regulates PPARs ; therefore , it is feasible that PPAR modulation is pivotal for mitochondrial protection by RAS blockade during rodent ageing.
RASSF1A , regarded as a candidate tumor suppressor , is frequently silenced and inactivated by methylation of its promoter region in many human tumors.
Raster scans in two orthogonal views , mediolateral and craniocaudal , were obtained using the ultrasonic through-transmission method.
Rat behavior was monitored using the Morris water maze , and the expression of beta-APP in rat brain tissue was detected via immunohistochemistry.
RA T cells have several hallmarks of cellular aging ; most importantly , they accumulate damaged DNA.
Rate and speed of recovery were assessed in the younger and older groups.
Rate-control drugs were more frequently used than rhythm-control drugs ( @percent@ vs. @percent@ , p < @number@ ) .
Rate limitations on motor production were estimated from the average inter-tap interval when tapping as fast as possible for @number@ s.
Rate of agreement of the two methods and characteristics of those identified using each approach were examined.
Rate of bone microarchitectural change was compared between cross-sectional models and actual change calculated from longitudinal analyses.
Rate of change in white matter volumes did not differentiate the groups.
Rate of cure was also measured for these four irradiation times at composite specimen surface and at @number@ mm depth.
Rate of paralyses decreased @percent@ annually from @number@ to @number@ ( odds ratio @number@ @percent@ confidence interval , @number@.93-0.97 ; P < @number@ ) .
Rate pressure product ( RPP ) was used as an index of myocardial oxygen demand.
Rates among those in the most deprived quintile were around @percent@ higher than the least deprived and were generally higher in the North of England.
Rates and age patterns differed markedly , as did gender patterns except in Hong Kong.
Rates identified by the BEHAVE-AD were intermediate and similar to those of the NPI-NH.
Rates of abnormal imaging in these groups were respectively @percent@ , @percent@ and @percent@.
Rates of CAP increase with age and CAP is associated with significant morbidity and mortality , especially in the elderly.
Rates of CDIV complications and 30-day mortality were analyzed based on mFI score using SAS version @number@
Rates of CI discontinuation increased by @percent@ per year of age at implantation ( @percent@ CI , @number@.2%-30.4% ) .
Rates of diagnoses of hypertension and obesity were higher among black , non-Hispanic service members than among other racial / ethnic groups.
Rates of diagnosis were determined for proposed PCBD , PGD and CG criteria.
Rates of ED transfers were compared between nursing home ownership types.
Rates of first occurrence ( per @number@ person-years ) were @number@ for DM , @number@ for CKD , and @number@ for HTN.
Rates of FTR after each type of postoperative complication also increased with age.
Rates of incarceration among these Vietnam veterans declined as they aged.
Rates of increase in agitation / aggression separately correlated with rates of declines in both cognition and independence.
Rates of network losses , deaths , and additions were modeled using multivariate Poisson regression.
Rates of nursing home residence 1-year following fracture were unchanged and remain high.
Rates of patient-reported AD completion ranged from @percent@ to @percent@ , while ADs were available to ED personnel for @percent@ to @percent@ of patients.
Rates of PN / SPN at @number@ years since parent study entry were @number@ and @number@ % , respectively.
Rates of reported incarceration declined from @number@ to @percent@.
Rates of smoking and use of alcohol were lower than in the general population but were higher with older age.
Rates of SSI ( per @number@ procedures ) were @number@ and @number@ for hip and knee arthroplasties , respectively.
Rates of temporal thinning in DLB were relatively preserved compared with AD.
Rates of these surgeries in North America are growing , coinciding with increasing obesity and an aging population.
Rates of transition from healthy aging to MCI , and MCI to AD , were consistent with established estimates.
Rates of transitions and associated factors were studied.
Rates of valvular operations increased significantly in all adult subgroups and in children with severe lesions.
Rates were calculated and regression analyses completed to assess trends over time.
Rates were higher when the patients had been transplanted from deceased donors compared to living donors.
Rather , an interaction between genetic and environmental factors may clarify the underlying disease mechanism.
Rather , a selective clonotype expansion must be included to achieve the best fit.
Rather , do they enhance automation , impose constraints on personal initiative , and result in compulsive consumption of information ?
Rather , GR activation resulted in genome-wide blockade of NF-κB interaction with chromatin and directly induced inhibitors of NF-κB and AP-1.
Rather , it highlights the need to explore restoration times in particular , and the nature of the refreshment mechanisms within maintenance.
Rather , it was less noisy.
Rather , joint homeostasis has been compromised and there are potentially reversible markers for heightened OA risk.
Rather , normal age-related depletions of testosterone in plasma and brain predict enhanced vulnerability to AD.
Rather , SADS is likely mediated by changes to higher-order nuclear structural proteins , such as LaminB1.
Rather , shrinkage of neurons , reductions of synaptic spines , and lower numbers of synapses probably account for the reductions in grey matter.
Rather , telomere shortening may progress in proportion to lifetime depression exposure.
Rather than a deterioration , there was an improvement of urinary parameters.
Rather than an isolated finding , tremor was associated with other measures of poorer motor hand function.
Rather than being an inevitable consequence of age , cognitive decline can occur with marked variation among individuals.
Rather than being a reaction to worsening cognitive performance with age , depressive symptoms might be a risk factor for age-related cognitive decline.
Rather than being compensatory , this appears to be maladaptive , with greater amplitude in the ventral default mode subnetwork associated with poorer episodic memory.
Rather than considering it a benign condition , it should be considered as a complicating condition for aging and oxidative stress.
Rather than developing pharmacological mimetics of DR , our focus should be on educating the public about DR in order to minimize age-related disease.
Rather than directly related to osteoporosis , AFs are a predictor of osteoporotic fractures in other sites.
Rather than using a surrogate model , the Austrian version of FRAX was adopted for clinical practice.
Rather , the 60s group reported greater familiarity and offered better explanations than did the 20s group.
Rather , the adolescent brain is likely to support the challenges specific to that period of life.
Rather , the capacity for LTP induction is reduced whereas that for LTD induction is enhanced.
Rather , the defect is the maintained permeability of kidney aquaporin-2 channels to water.
Rather , the majority of Jhy ( lacZ / lacZ ) cilia develop axonemes with 9 + 0 or 8 + 2 microtubule structures.
Rather , there was a trend towards better orthostatic tolerance , which might be attributed to stronger parasympathetic cardiovascular control and larger blood volume.
Rather , this disease is a chronic interstitial nephritis termed chronic kidney disease of nontraditional etiology ( CKDnT ) .
Rather , we argue that the decline in job changing has caused the decline in migration.
Ratings of goodness-of-fit were similar in the groups , as was ERP response to the note onset ( N1 ) .
Ratings of rash / eczema or tense lips were not significantly affected by sleep deprivation , nor associated with judgements of fatigue.
Ratio male / female in population over @number@ years in our study was @number@.76 : 1.
Rational and evidence-based management is particularly important in older individuals because they may experience greater toxicities from the therapeutic options.
Rational combinations of these drugs with physical exercise and an anti-aging diet ( Koschei formula ) can maximize their anti-aging effects and decrease side effects.
RATIONALE , AIMS AND OBJECTIVES : Declining capacity to function safely and independently in the community is a manifestation of ageing.
RATIONALE , AIMS AND OBJECTIVES : Departments of Emergency Medicine ( DEM ) have experienced increased demand largely because of the aging population.
RATIONALE , AIMS AND OBJECTIVES : Improving the possibilities for ageing persons to take control over their health is an increasingly important public health issue.
RATIONALE AND OBJECTIVES : Changes in the composition of body tissues are major aging phenotypes , but they have been difficult to study in depth.
RATIONALE AND OBJECTIVES : Differentiating mild cognitive impairment ( MCI ) and Alzheimer Disease ( AD ) from healthy aging remains challenging.
RATIONALE AND OBJECTIVES : Increased mammographic breast density is a significant risk factor for breast cancer.
RATIONALE : Because of its rapidly-growing and aging populations , the global burden of stroke will be felt most strongly in Asia.
RATIONALE : Black box warnings for young adults under the age of @number@ years indicate that antidepressants may increase risk of suicide.
RATIONALE : Cellular senescence is observed in the lungs of patients with COPD and may contribute to the disease pathogenesis.
RATIONALE : Chronic lung diseases are associated with cardiovascular disease.
RATIONALE : Chronic obstructive pulmonary disease ( COPD ) is often associated with age-related systemic abnormalities that adversely affect the prognosis.
RATIONALE : Currently there is no consensus on protein requirements for obese older adults during weight loss.
RATIONALE : Evidence suggests that depression is cross-sectionally and longitudinally associated with activation of inflammatory response system.
Rationale for studying old lesbians and the relevance of the articles contained in this issue are described.
RATIONALE : In aging HIV-infected populations comorbid diseases are important determinants of morbidity and mortality.
RATIONALE : Ischemic cardiovascular disease represents one of the largest epidemics currently facing the aging population.
RATIONALE : Leukocyte telomere length ( LTL ) is a biological marker of aging , and shorter LTL is associated with adverse cardiovascular outcomes.
RATIONALE : Menopause is associated with changes in sex hormones , which affect immunity , inflammation , and osteoporosis and may impair lung function.
RATIONALE : Metabolic syndrome ( MetS ) is a high-prevalence condition characterized by altered energy metabolism , insulin resistance , and elevated cardiovascular risk.
RATIONALE : Mitochondrial oxidative stress ( mitoOS ) has been shown to be increased in various cell types in human atherosclerosis and with aging.
RATIONALE : Myocardial function is enhanced by adoptive transfer of human cardiac progenitor cells ( hCPCs ) into a pathologically challenged heart.
RATIONALE : Survivors of acute lung injury ( ALI ) require ongoing health care resources after hospital discharge.
RATIONALE : The aging population may strain intensive care unit ( ICU ) capacity and adversely affect patient outcomes.
RATIONALE : The association between life course socioeconomic position ( SEP ) and subclinical atherosclerosis is not consistent across studies.
RATIONALE : There is a substantial body of literature documenting the deleterious effects of both alcohol consumption and age on driving performance.
RATIONALE : There is mounting evidence of a higher incidence of coronary heart disease in individuals.
RATIONALE : The turnover of cardiomyocytes in the aging female and male heart is currently unknown , emphasizing the need to define human myocardial biology.
RATIONALE : This paper builds on concepts introduced in paper @number@ of this series.
Ratio @number@ was not associated with ABP.
Ratios and differences were further examined for the influence of age , gender and level of intellectual disability.
Ratios of CPF bioactivation to detoxification ( CPF desulfuration to dearylation ) V ( max ) values were consistent across ages.
Ratios of p-tau / t-tau increased , while t-tau / Aβ42 decreased over @number@ months in patients with PD.
Rat models of subacute aging were established by continuous subcutaneous injection of @percent@ D-galactose.
Rats are a commonly used model for aging studies , and a frailty assessment tool for rats would be of considerable value.
Rats of the normal control and model groups were grabbed and fixed in the same way.
Rats were sacrificed after @number@ weeks.
Rats were then sacrificed after model prepared , no treatment was processed in the natural recovery group.
RA was first implicated in signalling on the basis of its teratogenic effects on limb development.
RA was larger in women ( @number@.63±0.16 vs @number@.26±0.08 mm ( @number@ ) , P = 0.05 ) and with increasing age.
Raw cognitive scores were converted to age-adjusted Z-scores ( W-scores ) and averaged to compute composite scores for each cognitive domain.
Raw data from IMUs were detrended , normalized and filtered to reveal kinematics peaks that corresponded to different activities.
Raw data suggested that retraining programmes may reduce the level of care patients required on discharge.
Raw ERG traces ( @number@.1-300 Hz ) were filtered ( 75-300 Hz ) to measure OPs trough-to-peak in the time-amplitude domain.
Raw fish consumption in restaurants , for example , Sashimi style , is popular worldwide.
Raw fish dishes are consumed at social gatherings from shared plates and dipping sauces using the same chop sticks.
Raw scores were transformed to age-adjusted scaled scores ( SS ( A ) ) based on percentile ranks.
Rb3 could not interfere with cell viabilities in UV-B-irradiated HaCaT keratinocytes.
Rb3 plays a protective role against UV-B-induced oxidative stress in human HaCaT keratinocytes , proposing its potential skin anti-photoaging properties.
RBC deformability was assessed by laser-diffraction analysis using a \ "slit-flow ektacytometer \ ".
RBC extracts and supernatants were assayed using a ultra-high-performance liquid chromatography separations coupled online with mass spectrometry detection metabolomics workflow.
RBCLS was @number@ ± @number@ days ( range @number@.7-115.8 days ) .
RBC membrane fatty acids were measured using gas chromatography.
RBC production factors , previously seldom reported , may play an important role and should be reported.
RBCs are prepared by blood banks from whole blood donations and stored in the cold in additive solutions for typically six weeks.
RBCs prepared after a 24-h period of RTH on day + 1 after collection ( RTH-RBCs ) were compared with RC-RBCs.
RBC storage time was not associated with changes in adaptive immune function.
RBCs were fractionated by discontinuous density centrifugation.
RBC transfusion had no short-term association with adaptive immune function.
RB farms earn high income from rubber and fatten cross-bred pigs , often using purchased feeds.
RBM24 is an RNA-binding protein and shares a high sequence similarity with RBM38 , a critical regulator of p63.
RCAs reported avoidability and factors contributing to readmissions.
RCF owners across Quebec were invited to complete a questionnaire that described the setting's physical and organizational environment.
RCFs in the United States totaled @number@ in @number@ with @number@ state-licensed , certified , or registered residential care beds.
RCFs serve primarily a private-pay adult population ( @number@ ) .
RCFs were most commonly located in the West.
Rcm1 , the yeast homologue of NSUN5 , methylates C2278 within a conserved region of 25S rRNA.
RCT showed a trend of toxicities increase compared with RT , however , the toxicities were tolerable and manageable.
RDW is a simple , inexpensive and easily accessible parameter that may be considered risk predictor especially in younger patients with CHF.
RE69995 ) .
Reablement focuses on early , time-intensive , multidisciplinary , multi-component and individualised home-based rehabilitation for older adults with functional decline.
Reablement is implemented in primary care in some Western countries to help meet these challenges.
Reach data were coded as either a 1-handed reach or a 2-handed reach.
Reaching is an important component of daily activities with goals to interact and acquire objects in the environment.
Reactants and energy support are needed for these reactions to take place in a cell.
Reactions were positive , and the project was perceived as beneficial to both students and older adults.
Reaction time and COP-COM measures significantly predicted group status in discriminant models with sensitivities and specificities of 72-100%.
Reaction time generally improved during heat stress , but there was no effect of heat stress on accuracy in either group.
Reaction time ( RT ) and the N400 ERP component were measured to examine age-related differences in bilingual language processing.
Reaction time ( RT ) distributional analyses indicated the slow tail of the RT distribution was related to reduced rs-fcMRI functional connectivity within the SAL.
Reaction times and errors were analyzed.
Reaction times and the resulting bilateral deficit , as well as reaction time variability were analyzed.
Reaction time ( secondary task ) increased significantly after fatigue , but only for older adults when standing on the CS.
Reaction time tasks are used widely in basic and applied psychology.
Reaction time was not associated with driving errors in multivariate analyses.
Reaction time was slightly faster on the test of embedded sentences among those with MetS.
Reactivation of the aged enzyme has not yet been demonstrated.
Reactivation of the varicella zoster virus ( VZV ) increases during aging.
Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease ( AD ) .
Reactive carbonyl compounds are stable and can diffuse within or even escape from the cell and attack targets far from the site of formation.
Reactive carbonyl compounds contribute to aging , Alzheimer's disease ( AD ) and other neurodegenerative diseases.
Reactive carbonyl species ( RCS ) have been widely used as indicators of oxidative stress.
Reactive control refers to the expression and suppression of responses and proactive control refers to the adjustment of response to previous situations.
Reactive gastropathy , which was detected in @percent@ of biopsies , increased with age and was the second most common factor of gastric pathology observed.
Reactive gliosis and glial scar formation have been evidenced in the animal model of ischemic stroke , but not in human ischemic brain.
Reactive oxygen and nitrogen species play a critical role in many degenerative diseases and in aging.
Reactive oxygen species and RNS productions often are reported to be associated with the development of chronic diseases and acceleration of the aging process.
Reactive oxygen species are responsible for vascular damage that leads to several cardiovascular pathological conditions.
Reactive oxygen species induced oxidative stress plays a major role in skin aging by modulating the elastase enzyme level in the skin.
Reactive oxygen species production was assessed in vitro by fluorescence and in vivo by nitrosylation of the proteins.
Reactive oxygen species ( ROS ) accumulated in cells during the stationary phase , and nth1Δ rad16Δ cells produced more ROS than WT cells.
Reactive oxygen species ( ROS ) and free radicals play important roles in the chemical transformation and adverse health effects of environmental aerosols.
Reactive oxygen species ( ROS ) and reactive nitrogen species ( RNS ) are known to play vital roles in aging-related MI / R injury.
Reactive oxygen species ( ROS ) and superoxide dismutase ( SOD ) levels were analyzed in the cells.
Reactive oxygen species ( ROS ) are at once unsought by-products of metabolism and critical regulators of multiple intracellular signaling cascades.
Reactive oxygen species ( ROS ) are commonly involved in the pathogenesis of skin damage by activating the metalloproteinases that break down type I collagen.
Reactive oxygen species ( ROS ) are generated spontaneously in all organisms and cause oxidative damage to biomolecules when present in excess.
Reactive oxygen species ( ROS ) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process.
Reactive oxygen species ( ROS ) are oxidizing agents amply implicated in tissue damage.
Reactive oxygen species ( ROS ) generated during ultraviolet ( UV ) light exposure can induce skin damage and aging.
Reactive oxygen species ( ROS ) have been shown to be a contributor to aging and disease.
Reactive oxygen species ( ROS ) increase intra-cellular calcium and enhance the formation of mPTP that leads to neuronal cell death in AD.
Reactive oxygen species ( ROS ) -induced DNA damage is repaired by the base excision repair pathway.
Reactive oxygen species ( ROS ) scavengers completely inhibited MALM.
Reactive oxygen species ( ROS ) superoxide and hydrogen peroxide perform important signaling functions in many physiological and pathophysiological processes.
Reactive oxygen species was detected by dichlorofluorescein diacetate ( DCFH-DA ) .
Reactive persulfide species such as cysteine persulfides and polysulfides that are endogenously produced in cells are likely to be involved in 8-nitro-cGMP metabolism.
Reactivity to daily stress did not differ for individuals of different ages or for individuals with different levels of self-concept incoherence.
Read and answer each question on the quiz.
Re-addition of serum caused mTOR-dependent senescence in the presence of etoposide or doxorubicin.
Readers in an experimental group received instruction in making conceptual links during reading while readers in a control group were simply encouraged to allocate effort.
Readers of the poem can simultaneously experience the suffering of an old man and the identity crisis of a young man.
Readiness to implement evidence-based programs as low at baseline as all site leaders described needing to secure additional resources for program implementation.
Readmissions were associated with delays in functional recovery in all measures of physical function.
Reagents that specifically recognize oligomeric morphologies of Aβ have potential diagnostic and therapeutic value.
RealAge participants showed significantly decreased waist circumference at @number@ and @number@ months ( P = @number@ P = @number@ ) .
RealAge predicts deaths from malignant neoplasms , heart disease , and external causes.
Real and imagined walking task times were strongly correlated , particularly real and imagined dual-task times ( WWT and iWWT ) .
Realistic geometry and material properties need to be included in the computational models in future studies.
Real-life episodic memories are about events in their spatiotemporal context and are typically visuospatial , rather than verbal.
Real-time analysis of RPA-ssDNA binding demonstrated that Cdc45 catalytically loaded RPA onto ssDNA.
Real-time PCR analysis showed that matrix metalloproteinase @number@ ( MMP-1 ) and MMP-13 mRNA were significantly increased by SIRT6 inhibition.
Real-time PCR reactions employed appropriate primers.
Real Time-PCR was performed to investigate several gene expressions.
Real-time PCR with a greater number of samples indicated that the increase in miR-124 levels in senescent facial skin was statistically significant.
Real-time peak contact pressures and contact areas were recorded throughout the full range of motion.
Real-time polymerase chain reaction was used to measure messenger RNA ( mRNA ) expression , and Western blot was used to detect protein expression.
Real-time quantitative PCR and fluorescent microsatellite quantitative PCR were similar individually but are theoretically complementary ; we used Illumina arrays as our reference assay.
Real-world evidence on adherence to GLP-1RAs in elderly or disabled patients is limited.
Reappraisal and suppression induction led to reductions in nonverbal and verbal indices of pain.
Rearranging the symbols of the key after @number@.0±8.1 months returned SDMT scores to baseline indicating a practice effect.
Reasoning and speed , but not memory , training resulted in improved targeted cognitive abilities for @number@ years.
Reasons for change vary by age , sex and SEP.
Reasons for inadequate pain control by clinicians include lack of training , inadequate pain assessment and reluctance to prescribe opiates.
Reasons for nonadherence were illness ( @percent@ ) and lack of motivation ( @percent@ ) .
Reasons for nonparticipation were travel , family obligations , and being too busy.
Reasons for poor blood pressure control include low awareness of hypertension among health-care professionals and patients , under-treatment , and tolerability problems with antihypertensive drugs.
Reasons for relationship difficulty ranged from intimate partner abuse to terminal illness.
Reasons for testing included planning for the future , relieving uncertainty , informing children and satisfying curiosity.
Reasons for this should be explored using longitudinal studies and a full battery of cognitive tests that do not rely on vision.
Reasons leading to DWLSTs are different according to the age of patients.
Reasons that lead to this high burden should be checked at the first visit.
Reasons why respondents maintained or changed average alcohol consumption were asked of those who completed a 12-month assessment by telephone.
Recalculated weighted models revealed almost identical estimates indicating no relevant non-response bias.
Recalled max BMI value was within three BMI units of the calculated value @percent@ of the time.
Recalled weight should be used with caution.
Recall of previously distracting words was age-equivalent in the indirect condition , but young adults recalled more distracting words in the direct condition.
Recall was tested at both the 30-min typically used delay and a 1-week delay used to target consolidation.
Recanalization using tissue plasminogen activator only modestly improves patient outcome , and inhibiting excitotoxicity has shown no clinical benefit.
Receiver operating characteristic analyses showed values of area under the curve of @number@.76-0.80 for the different genotypes indicating a good diagnostic validity of the test.
Receiver-operating characteristic analyses were performed for predicting all-cause mortality , and discriminatory performance was assessed.
Receiver operating characteristic analyses were used to assess the discriminative power for hospital mortality prediction.
Receiver operating characteristic analysis determined the sensitivity and specificity of CE indexes.
Receiver operating characteristic analysis was used to determine which summary score best differentiated between the four cognitive states.
Receiver operating characteristic analysis was used to estimate hand-grip strength cut points for likelihood of mobility limitation.
Receiver operating characteristic curves for the UFOV ( Risk Index [ RI ] and Subtests 1-3 ) and Trails B significantly predicted on-road outcomes.
Receiver operating characteristic curves were used to compare the @number@ Timed Up and Go groups to current standard-of-care surgical risk calculators at forecasting postoperative complications.
Receiver operating characteristic ( ROC ) analyses were employed to assess the predictive power of each cognitive classification.
Receiver operating characteristic ( ROC ) curve analysis was used to assess overall ' diagnostic ' accuracy of TMT-A and -B for driving competency.
Receiver-operating characteristic ( ROC ) curves and logistic regression analyses were conducted.
Receiver operating characteristic ( ROC ) curves , area under the curve ( AUC ) , and thresholds were calculated for each model.
Receiver operating characteristic ( ROC ) curves are commonly used to summarize the classification accuracy of diagnostic tests.
Receiver operating characteristic ( ROC ) curves were completed to determine the sensitivity and specificity of the cut-off point for high nutrition risk.
Receiver Operating Curves analysis provides insight into sensible cut-offs ( AUC varied from @number@ to @number@ ) .
Receiver operator characteristic curves were used to examine the ability of AD8 and IQCODE to discriminate between controls and MCI or dementia.
Receiver operator curve ( ROC ) analysis was also performed.
Receivers operating curves were established in order to explore the existence of a possible threshold of vitamin D levels highly predictive of frailty.
Receiving an indwelling urinary catheter is a risk factor for developing UTIs.
Receiving SSI was associated on multivariate analysis with poorer NP performance independent of lack of full time work , or nadir CD4 count.
Receiving support from friends or neighbors is associated with fewer depressive symptoms.
Recency of examination was not attenuated by adjusting for additional risk factors.
Recent addition of a compression handpiece ( CHP ) allows treatments with minimal adverse effects.
Recent advancement of methodologies has made it possible to quantify these compounds more reliably and apply them in various in vivo studies successfully.
RECENT ADVANCES : A growing literature suggests that over @number@ proteins are S-nitrosylated in cell systems.
RECENT ADVANCES : Antioxidant , protective effects may arise as a reaction to a low-level pro-oxidant activity , largely taking place at mitochondria.
RECENT ADVANCES : A selenoprotein MsrB1 knockout mouse has been developed.
RECENT ADVANCES : Both receptor-dependent and PTEN-induced putative kinase 1-PARKIN-dependent mitophagy have been described.
Recent advances characterizing the neurocognitive profile of HS-Aging patients have begun to provide clues that may help identify living individuals with HS-Aging pathology.
RECENT ADVANCES : CSCs reside in the adult heart and govern myocardial homeostasis and repair after injury by producing new cardiomyocytes and vascular structures.
Recent advances focused on new implementation processes for evidence-based best practices such as checklists and bundles have transformed medical care.
Recent advances have focused on how PUFA regulate the molecular signaling of microglia , especially in the context of neuroinflammation and behavior.
Recent advances have identified a conserved response of germ line RNPs to environmental stresses such as nutritional stress and heat shock.
RECENT ADVANCES : Herein , we review the evidence for disturbances in mitochondrial function in skeletal muscle and the heart in the diabetic state.
RECENT ADVANCES : Here , we review current knowledge and latest developments in MQC.
Recent advances in biogerontology allow a clearer view of the ethical issues and dilemmas that confront humanity with respect to treating ageing.
Recent advances in biomarker studies on dementia are summarized here.
Recent advances in delineating the biological functions of p53 had shed the light on its key role in the multifacets of cellular homeostasis.
Recent advances in heart failure pharmacotherapy have established several agents as beneficial to disease progression and outcomes.
Recent advances in high-throughput sequencing allow researchers to examine the transcriptome in more detail than ever before.
Recent advances in molecular biology help to understand the complexity of atherosclerosis.
Recent advances in radiotherapy and chemotherapy have led to higher cure rates for female children and adolescents with cancer.
Recent advances in technology introduced a new wavelength , @number@ nm , erbium : ( Er : YSGG ) for treatment of photoaging.
Recent advances in technology now allow detailed analysis of complex immune interactions relevant to disease susceptibility.
Recent advances in the understanding of aging have paved a new way of thinking about intervening with the aging process.
Recent advances in understanding AD pathogenesis have led to the development of numerous compounds that might modify the disease process.
RECENT ADVANCES : New work has illuminated multiple links between mitochondrial sirtuins and cancer.
Recent advances of mobile technologies have made mobile devices a promising tool to manage patients ' own health status through services like telemedicine.
RECENT ADVANCES : Recent findings implicate redox metabolism in the control of stem cell pool and stem cell aging.
Recent advances suggest that stem cell therapy could one day be used to treat nerve traumas.
RECENT ADVANCES : There have been a number of results in nematodes that appear to contradict long-held beliefs about mechanisms and causes of aging.
Recent Advances : There is increasing evidence to suggest that aging is associated with an imbalance between oxidative stress and antioxidant status.
RECENT ADVANCES : Usually , in peripheral blood , ROS / RNS production is balanced by the rate of oxidant elimination.
Recent advantages in the anatomical understanding of the face have turned the focus toward the subcutaneous and deep facial fat compartments.
Recent analyses have provided new insights on the biochemical and functional dynamics of CHIP.
Recent animal data support androgens in promoting preantral follicle growth and reduction in follicle atresia.
Recent animal studies have reported that exercise pressor reflex ( EPR ) -mediated increases in blood pressure are exaggerated in hypertensive ( HTN ) rodents.
Recent application of oral SLNs includes therapies for cancers , central nervous system-related disorders , cardiovascular-related diseases , infection , diabetes , and osteoporosis.
Recent application of whole exome sequencing on carefully selected families with POI has also revealed a significant contribution of DNA damage response genes.
Recent appreciation of the multifactorial pathophysiology of skin aging has led to increased use of parallel treatment regimens.
Recent attempts to regulate redox state have focused on electrophiles ( EPs ) , which activate potent cellular defense systems against oxidative stress.
Recent biochemical and molecular studies have given new insights into the multifaceted roles of RecQL4 that range from genomic stability to carcinogenesis and beyond.
Recent biogerontological findings in Ukraine are critically reviewed.
Recent breakthroughs have provided notable insights into both the pathogenesis and therapeutic strategies for age-related hearing loss ( ARHL ) .
Recent clinical and experimental studies have reported aging and anti-neurodegenerative effects of DJS.
Recent clinical evidence suggests that the neuroprotective and beneficial effects of hormone therapy may be limited by factors related to age and reproductive status.
Recent clinical studies have confirmed the link between serum protein carbamylation and morbi-mortality in patients suffering from CKD or undergoing hemodialysis.
Recent clinical trials have shown that vitamin D supplements significantly enhance the efficacy of interferon plus ribavirin therapy through sustained virological response.
Recent clinical trials of oral DHEA and reviews of those trials have failed to show any health benefits for postmenopausal women.
Recent clinic- and population-based studies have demonstrated a link between retinal vascular changes and dementia , in particular AD , and cerebral small vessel disease.
Recent cohorts had lower amyloid deposition.
Recent critics offer a mixture of old and new objections to this analysis.
Recent cross-species studies have begun to identify pathways responsible for interspecies differences in lifespan.
Recent data also link bilirubin to other chronic diseases , including cancer and Type @number@ diabetes mellitus , and to all-cause mortality.
Recent data have demonstrated that calcium salt deposition in soft tissues could be a highly regulated process.
Recent data indicate elevated metabolic stress as a possible explanation for DA neuron vulnerability.
Recent data indicate that Alzheimer's disease ( AD ) is associated with disturbances of the circadian rhythm in patients.
Recent data indicate that bacteria although short lived produce , metabolize and accumulate AGEs.
Recent data indicate that low testosterone and high estradiol favor disease progression.
Recent data in mouse models suggest that cell death could provide a potent trigger of inflammation.
Recent data point to an important role of the intrathymic transforming growth factor-β ( TGF-β ) circuitry.
Recent data revealed long-term LTP maintenance ( L-LTP ) is impaired in PS1-M146V knock-in ( KI ) FAD mice.
Recent data showed that the selective VDRA paricalcitol might have ameliorative CV effects.
Recent data show that nicotinamidases are required for the growth and virulence of several pathogenic microbes.
Recent data show the involvement of senescent cells in tissue ageing and some age-related diseases.
Recent data suggests that Cox-2 expression decreases with age in mouse bone tissue.
Recent data suggest that chronic low-grade inflammation , a fundamental characteristic of aging , plays a role.
Recent decades have witnessed a proliferation of medical pharmacologic therapies and innovative surgical interventions like deep brain stimulation ( DBS ) .
Recent development in the field further uncovered the utility of anti-Wip1-directed therapies in delaying tumor onset or in reducing the tumor burden.
Recent developments in basic and translational immunology open new exciting perspectives for inducing transplantation tolerance in the clinic.
Recent developments in fractionated light therapy have allowed for PDT with dark intervals and two-fold illumination schemes to increase cellular damage and apoptosis.
Recent developments in the analysis of epigenetic DNA methylation patterns have demonstrated that certain genetic loci show a linear correlation with chronological age.
Recent developments in therapeutic molecule and peptide delivery to the skin via MN platforms are addressed and some commercially available MN devices are described.
Recent developments in the tool box to study senescence have made it possible to begin addressing these questions.
Recent direct-to-consumer marketing and educational efforts would have been expected to increase awareness and treatment options.
Recent discoveries indicate that disorders of protein folding and degradation play a particularly important role in the development of lung diseases and their associated complications.
Recent double-blind , placebo-controlled human studies provided evidence to support some of these claims.
Recent efforts by our lab have provided scientists with cost-effective alternatives to expensive commercial labels.
Recent efforts have resulted in the advent of a weighted scoring system that could sensitively capture multiple-organ comorbidities prior to HCT.
Recent electrophysiological work has evinced a capacity for plasticity in subcortical auditory nuclei in human listeners.
Recent epidemiological and experimental studies suggest a link between cognitive decline in late adulthood and sports concussions sustained in early adulthood.
Recent epidemiological evidence shows that cardiovascular risk is not only related to the average arterial pressure , but also to the degree of diurnal variability.
Recent epidemiological investigations have highlighted the high prevalence of vestibular dysfunctions in the adult population and its association with aging.
Recent epidemiological studies from various countries point at the mounting incidence of cancer.
Recent epidemiologic data suggest that deficits in processing speed predict future injurious falls.
Recent events had higher levels of reliving and vividness than remote events , and older adults reported a stronger recollective experience than younger adults.
Recent evidence also suggests active crosstalk between proteasome-mediated degradation and selective autophagy.
Recent evidence also suggests that mitochondrial DNA may play an important role in attaining longevity.
Recent evidence corroborating the statement of the \ "aging theory for COPD \ " was also discussed.
Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility.
Recent evidence from animal studies suggests that hyperactivity in the CA3 region of the hippocampus may underlie behavioral deficits in pattern separation in aged rats.
Recent evidence has demonstrated that activating Sirt1 induces autophagy , and that activating autophagy protects neurons against neurodegenerative disorders by regulating mitochondrial homeostasis.
Recent evidence has depicted a rather unique role of autophagy as another important pathway in the regulation of longevity and senescence.
Recent evidence has emerged to aid the investigating clinician in formulating an accurate diagnosis and in implementing a successful treatment algorithm.
Recent evidence has emerged to suggest a broad range of biological activities.
Recent evidence has indicated that neuronal activity related to reward anticipation benefits subsequent stimulus processing , but the effect of penalties remains largely unknown.
Recent evidence has raised animated discussion of the possibility that intensive glucose control may cause more harm than benefit , especially in older adults.
Recent evidence has shown benefits with angiotensin-converting enzyme inhibitors ; however , further randomized controlled trials are required.
Recent evidence has shown that DNA replication stress is a major driver of genomic instability and tumorigenesis.
Recent evidence has shown that standard chemotherapy is not as effective in hosts devoid of T cells.
Recent evidence implicates alterations in neurotrophins in the pathogenesis of neurodegeneration associated with HAND in the context of aging.
Recent evidence indicates a role for Aβ oligomers in regulating synaptic plasticity with excess amounts of oligomers disrupting synaptic function.
Recent evidence indicates that cellular senescence provides a barrier to tumorigenesis and is a determinant of the outcome of cancer treatment.
Recent evidence is consistent with the hypothesis that oocyte mitochondria escape the aging process by acting as quiescent genetic templates , transcriptionally and bioenergetically repressed.
Recent evidence of acute liver failure and fibrosis / cirrhosis is also emerging in OTC-deficient patients.
Recent evidence points out that insulin affects central nervous system functions , and can modulate cognitive functions.
Recent evidence revealed a role of the HP in protein quality control and ageing.
Recent evidence shows that iron induces the endocytosis of the iron transporter dimetal transporter @number@ ( DMT1 ) during intestinal absorption.
Recent evidence suggests that an age-associated loss of muscle precursor cell ( MPC ) functionality contributes to sarcopenia.
Recent evidence suggests that emotional well-being improves from early adulthood to old age.
Recent evidence suggests that folic acid improves cutaneous vasodilation during localized and whole body heating through nitric oxide-dependent mechanisms.
Recent evidence suggests that impaired cognition increases seniors ' risk of falling.
Recent evidence suggests that lifelong bilingualism may contribute to cognitive reserve ( CR ) in normal aging.
Recent evidence suggests that NO bioavailability can be augmented by dietary nitrate through the nitrate-nitrite pathway.
Recent evidence suggests that patients with gastrointestinal disorders have increased intestinal permeability.
Recent evidence suggests that polycystic kidney disease is characterized by defects in urinary concentrating mechanisms and subsequent deregulation of vasopressin excretion by the neurohypophysis.
Recent evidence suggests that Ral signalling pathways may be potential therapeutic targets for the treatment of human cancers.
Recent evidence suggests that the gene also exerts controlling functions on follicle recruitment and ovarian reserve ( OR ) .
Recent evidence suggests that the gut microbiome may play a key role in age-related inflammation.
Recent evidence suggests that turnover of damaged mitochondria by autophagy might be central to the process of recessive parkinsonism.
Recent evidence suggests that unawareness of an olfactory deficit may predict which MCI patients will subsequently meet AD criteria.
Recent evidence suggests that α-Klotho suppresses the insulin and Wnt signaling pathways , inhibits oxidative stress , and regulates phosphatase and calcium absorption.
Recent evidence supports a role for mitochondrial dysfunction and increased oxidative stress in PD pathogenesis.
Recent experimental cross-sectional , and case-control studies have shown that testosterone may affect the hemostatic / fibrinolytic system in men in several ways.
Recent experimental data have shown that gingival wound healing is severely affected by the aging process.
Recent experiments provided new insights into AF pathophysiology , which generated background for new mechanism-based therapies.
Recent experiments suggest that therapies aimed at sustaining circadian function increase quality of life in elderly patients.
Recent field studies suggest that it is common in nature for animals to outlive their reproductive viability.
Recent findings about the effects of rapamycin on Alzheimer's disease-associated neuropathology will be also discussed.
RECENT FINDINGS : Accelerated aging due to exposure to cigarette smoke is hypothesized to induce rapid progression of COPD.
RECENT FINDINGS : Aerobic exercise reduces pTAG ; however , recent findings confirm that this effect is only evident with an accompanying energy deficit.
RECENT FINDINGS : A frailty assessment can help to stratify heart failure patients at high risk for adverse outcomes.
RECENT FINDINGS : Age cutoffs to define OABD range from @number@ to @number@ years.
RECENT FINDINGS : Age has been repeatedly confirmed as a major therapy-independent negative prognostic factor.
RECENT FINDINGS : Aging has been shown to not only enhance vulnerability to acute liver injury but also increase susceptibility of the fibrotic response.
Recent findings and future perspectives of therapeutic intervention are discussed.
RECENT FINDINGS : Animal and human studies suggest that high-frequency , low-magnitude vibration therapy improves bone strength by increasing bone formation and decreasing bone resorption.
RECENT FINDINGS : An increasing body of evidence has supported the role of the Mediterranean diet and extra-virgin olive oil in protecting cognition.
RECENT FINDINGS : Approximately 1-5% of patients with sarcoidosis die from complications of sarcoidosis.
RECENT FINDINGS : Approximately , one quarter of all women suffer from at least one or more PFDs.
RECENT FINDINGS : A preponderance of evidence exists establishing that gender nonconforming elders are subject to discriminatory healthcare treatment.
RECENT FINDINGS : ARHL has recently been associated with cognitive impairment and dementia.
RECENT FINDINGS : Autophagy is directly involved in the regulation of skeletal muscle mass.
RECENT FINDINGS : A variety of well validated assessment approaches are now available.
RECENT FINDINGS : Caloric restriction is a research priority for the US National Institute on Aging.
RECENT FINDINGS : Cataract is the leading cause of blindness , especially in developing countries.
RECENT FINDINGS : Consensus on the definition of sarcopenia and sarcopenic obesity is proposed.
RECENT FINDINGS : Crystals are found in both loaded and unloaded regions of articular cartilage.
RECENT FINDINGS : Daily administration of oral DHEA achieves serum concentrations similar to those of women in their 20s.
RECENT FINDINGS : Diagnostic studies of MR-neurography and high-resolution ultrasound in entrapment-neuropathies consistently report accurate determination and localization of symptomatic nerve entrapment.
RECENT FINDINGS : Disparities are evident within rural settings for patients with cardiovascular disease.
RECENT FINDINGS : Epidemiologic studies show greater protein intake to be beneficial to bone health in adults.
RECENT FINDINGS : EV research is a new and quickly developing field.
RECENT FINDINGS : Few lifestyle interventions focus on improving nutrition in childhood cancer survivors.
RECENT FINDINGS : Findings have substantially extended the clinical utility of BNP / NT-Pro-BNP assay.
RECENT FINDINGS : Fourteen studies were retained for the present review.
RECENT FINDINGS : Frailty is a term used to describe vulnerability in aging.
Recent findings from studies in human hearts are presented , including evidence that the autophagic response is intact in the aged human heart.
RECENT FINDINGS : Functional status as a criterion for preoperative assessment of older patients has been introduced in the last years.
RECENT FINDINGS : Ghrelin regulates glucose homeostasis by inhibiting insulin secretion and regulating gluconeogenesis / glycogenolysis.
Recent findings have also raised the possibility of functional rejuvenation in the aged hippocampus.
Recent findings have revealed age-related changes in neural recruitment during the processing of emotional information.
RECENT FINDINGS : HDL heterogeneity - both structural and functional - is the main focus of this review.
RECENT FINDINGS : Healthcare-related expenses occupy an expanding portion of gross domestic product in the US and are a driver of the deficit.
Recent findings , however , indicate that dysfunctional mitochondrial DNA ( mtDNA ) methylation could underlie aging and disease.
Recent findings , however , suggest a much broader involvement of this system in an array of physiologic responses to light.
RECENT FINDINGS : Increasing evidence supports the expanded use of ambulatory surgery for managing elderly patients undergoing elective surgery procedures.
Recent findings indicate that H3.3 replaces the majority of canonical H3 in non-dividing cells , reaching almost saturation levels in a time-dependent manner.
RECENT FINDINGS : Individuals with sickle cell disease ( SCD ) are living longer and develop progressive organ damage including SBD with age.
RECENT FINDINGS : In the last decades several cellular pathways playing a crucial role in muscle tissue regeneration have been described.
RECENT FINDINGS : It is expected that climate change will lead to higher global average surface temperatures and more extreme climatic conditions.
RECENT FINDINGS : It is known that even in youth , there are sex differences in skeletal health.
RECENT FINDINGS : Klotho functions as a receptor for the phosphaturic hormone FGF23.
RECENT FINDINGS : LLD is associated with brain changes , including atrophy of hippocampus , independent of other neurodegenerative states.
RECENT FINDINGS : Many of these chronic illnesses can be partially blamed by altered lipid metabolism , combined with individual genetic components.
RECENT FINDINGS : Many studies in patients with CAP have suggested that chronological age is not necessarily independently associated with mortality.
RECENT FINDINGS : Microparticles release is an integral part of the erythrocyte ageing process , preventing early removal of RBCs.
RECENT FINDINGS : Modulations of muscle mass in the adult reflect an imbalance between protein synthesis and degradation rates.
RECENT FINDINGS : Most data come from eight studies , with the majority being Scandinavian.
RECENT FINDINGS : New literature suggests that the incidence of olfactory loss increases with age.
Recent findings of the Multi-Ethnic Study of Atherosclerosis indicate further that increased CIMT predicted CVD events in individuals without coronary calcification.
RECENT FINDINGS : Paradoxically , bone loss may occur not only due to HIV / AIDS but also as a consequence of HAART.
RECENT FINDINGS : Population of older adults is growing and so is the prevalence of diabetes in elderly individuals.
RECENT FINDINGS : Premature T-cell senescence occurs not only in RA , but also has been involved in morbidity and mortality of chronic HIV infection.
RECENT FINDINGS : Profound qualitative and quantitative changes occur in the adaptive and innate immunity compartments during aging.
RECENT FINDINGS : Recent findings challenge the established link between neuroimaging biomarkers of neurodegeneration and age-related or disease-related cognitive decline.
RECENT FINDINGS : Recent research shows that bone-derived factors can lead to changes in the skeletal muscle.
RECENT FINDINGS : Recent studies enriched considerably our understanding of the relationship between aging and gene-nutrient interactions that continuously shape our phenotype.
RECENT FINDINGS : Recent work has served to refine and expand upon the clinical phenotype of the logopenic variant.
RECENT FINDINGS : Respiratory mechanics change progressively during aging , and the pharmacology of different drugs is also altered with increasing age.
Recent findings showed that high disease activity of RA might impair fertility.
Recent findings show that iron deficiency and inflammation regulate FGF23 release and / or biodegradation.
RECENT FINDINGS : Significant inroads have been made to understand how INSL3 is working in testicular descent.
RECENT FINDINGS : Specific muscle mass , strength and function cut-points for the diagnosis of sarcopenia have been identified.
RECENT FINDINGS : Stem cells were long considered as a fountain of youth and were assumed to be equipped against any form of aging effect.
RECENT FINDINGS : Studies indicate clear impairments in satellite cell function with aging , resulting in an impaired muscle fiber regenerative response.
Recent findings suggest that AA amyloidosis could be transmissible.
Recent findings suggest that Notch-1 signaling contributes to neuronal death in ischemic stroke , but the underlying mechanisms are unknown.
Recent findings suggest that these and other related biochemical processes governed by the organelle may also play a critical role in regulating cellular aging.
Recent findings suggest the intimate involvement of programmed cell death ( PCD ) in the turnover of NSCs.
RECENT FINDINGS : Technology use varied in type and extent of use across the different areas that have been reviewed.
Recent findings that elderly healthy individuals showed similar impairment on conditional exclusion task as schizophrenia patients raised the question whether similar processes are impaired.
RECENT FINDINGS : The beneficial effects of dietary protein on muscle health in older adults continue to be refined.
RECENT FINDINGS : The inconsistency in defining NHAP is considered a potential hindrance for a uniform approach to the management of pneumonia.
RECENT FINDINGS : The malnutrition-inflammation score ( KALANTAR Score ) is among the comprehensive and outcome-predicting nutritional scoring tools.
RECENT FINDINGS : The PET / computed tomography method likely underestimates the prevalence of BAT because it measures only active BAT.
RECENT FINDINGS : There are a few recent thermotherapy studies regarding the outcome of thermotherapy in LUTS / BPH patients.
RECENT FINDINGS : There are an increasing number of urinary incontinence studies outside Europe and North America.
RECENT FINDINGS : The recent studies confirm an increase in population TSH distribution with age , both in cross-sectional and longitudinal studies.
RECENT FINDINGS : There is a growing body of research investigating the use of high-intensity interval training in older adult to improve health-related outcomes.
RECENT FINDINGS : These findings implicate alterations in host defense , cell-to-cell adhesion , and aging and senescence in the pathophysiology of pulmonary fibrosis.
RECENT FINDINGS : These recent findings suggest that the end-of-life is molecularly and physiologically highly stereotyped , evolutionarily conserved and predictable.
RECENT FINDINGS : This article outlines the role of platelets as modulators of immune responses in the context of atherosclerosis.
RECENT FINDINGS : Throughout most points of life , men and women of similar health status and BMI display fairly similar protein turnover rates.
RECENT FINDINGS : We identified successful strategies and promising practices for improving medication adherence among patients diagnosed with CHD.
Recent genetic discoveries and understanding of the pathogenic pathways in AMD in relation to systemic disorders are also highlighted.
Recent genome wide association studies have identified a number of single nucleotide polymorphisms associated with late onset Alzheimer's disease ( LOAD ) .
Recent genome wide association studies have implicated bridging integrator @number@ ( BIN1 ) as a late-onset Alzheimer's disease ( AD ) susceptibility gene.
Recent guidelines for hypertension have made recommendations for older adults but are supported by evidence that includes younger individuals.
Recent guidelines suggest the use of opioids as the frontline treatment of moderate and severe pain in nononcological pain in the elderly.
Recent GWAS and network analyses have also implicated Cbp as the most connected gene in protein-protein interactions in human Type @number@ diabetes.
Recent health reforms have increasingly shifted the bulk of care of individuals from health care institutions to private homes and communities.
Recent improvements of implant and surgical technique brought the change of postoperative physical therapy , shortened hospital stay and increased patient's activity.
Recent initiatives seek to reduce ED visits and hospitalizations by providing financial incentives to spur better coordination between NH and hospital.
Recent innovations in brain imaging have detected characteristic disruptions in functional networks.
Recent innovations in the percutaneous treatment of valvular diseases promise a revolution in the treatment of aortic stenosis especially in older adults.
Recent insights concerning the regulatory pathways that modify hepcidin expression have identified novel targets for drug development.
Recent insights into the age-related molecular changes of the outflow tract and retinal ganglion cells have encouraged search for new treatment approaches.
Recent investigations have shown that periostin influences collagen fibrillogenesis and biomechanical properties of murine connective tissues.
Recent investigations , however , have fuelled interest in adult BAT.
Recent investigations report a higher risk of motor symptoms in females with the FMR1 premutation ( PM-carriers ) than has hitherto been appreciated.
Recent investigations suggest that inflammation constitutes a biological foundation of ageing and the onset of age-related diseases.
Recent investigations support that an anti-aging protein , namely Klotho , protects neurons against the oxidative stress and demyelination.
Recent lipid guidelines have raised this concern , yet statin therapy is recommended in ' at risk ' older adults.
Recent literature indicates that anti-Ro antibodies may be associated with various rhythm and conduction disturbances in the adulthood.
Recent literature is divided on whether the most commonly used method underestimates or overestimates this loss.
Recently , accumulation levels of AGEs in the skin can be measured non-invasively by autofluorescence.
Recently , a collaboration between the National Hartford Centers of Gerontological Nursing Excellence and NEXus was formalized.
Recently , activation of toll-like receptor ( TLR ) signaling has been recognized as an alternative activator of obesity-induced inflammation.
Recently adiponectin protein has been reported in murine vascular endothelial cells , however , whether adiponectin is present in human vascular endothelial cells remains unexplored.
Recently , a few studies have demonstrated that phthalates could cause oxidative stress which would contribute to the development of IR.
Recently , aggressive advertisement claimed a \ "magic role \ " for plant stem cells in human skin rejuvenation.
Recently , aging population and immuno-compromised patients have been rising in Japan.
Recently , a greater number of osteoporosis studies are either including men or focusing specifically on them.
Recently , a human cell line , EndoC-βH1 , was generated.
Recently , a key role in memory T cell homing and survival has been attributed to the bone marrow ( BM ) in mice.
Recently , a method for generating induced pluripotent stem cells ( iPSCs ) was developed.
Recently , a new assay for the differential diagnosis of progressive supranuclear palsy ( PSP ) was proposed.
Recently , a new class of APC methods based on modern statistical knowledge has emerged , offering potential solutions.
Recently a new level of complexity was added to the field of splicing of VEGF pre-mRNA.
Recently , a new mechanism of aging-detrimental epigenetic modifications-has emerged.
Recently , a new method that enables DNA to be stored at room temperature was developed.
Recently , an increasing number of studies have reported proteomic expression data for OATP transporters.
Recently , an inverse relationship with stroke risk was noted when the DBP was < 71 mm Hg in persons older than @number@ years.
Recently , another class of active ingredients called gintonin was identified.
Recently , another important factor associated to CV risk in CKD has been deeply investigated : vitamin D deficiency.
Recently , a novel assay system for TRAP-5b , the fragments absorbed immunocapture enzymatic assay method , has been developed.
Recently , a number of agents have been developed to target various components of the BCR pathway.
Recently , a number of drugs and substances [ in addition to insulin and its mimics ] have shown promising potentials against diabetes-induced brain injury.
Recently , as aging has become a familiar phenomenon around the world , patients with AD are increasing in number.
Recently , atomic force microscopy ( AFM ) has emerged as an ideal method for the non-invasive examination of hair surfaces.
Recently , attempts have been made to use numerous foods and natural products to prevent or treat diseases based on scientific evidence.
Recently , autophagy emerged as a key mechanism to eliminate unwanted cytoplasmic materials , thereby preventing cellular damage and stress to safeguard long-lived podocytes.
Recently , available as a dietary supplement , Berberine is reported to have application in treatment of variety diseases.
Recently , Aβ oligomers have been identified as more neurotoxic than Aβ plaques.
Recently , bile acid / FXR signaling pathway is shown to be required for normal liver regeneration.
Recently , both age-related protein glycation and relative amino-acid composition have been identified as potential risk factors for photo-ionization and / or photo-sensitization.
Recently , brain synthesis of androgen and estrogen has been extensively investigated.
Recently , clinical studies have shown totally different numbers for pathology.
Recently , criteria to better characterise PD-MCI and its subtypes have been produced by the Movement Disorder Society.
Recently , data from several clinical studies confirm that denosumab improves fracture outcomes , also at skeletal sites rich in cortical bone.
Recently described anti-sRAGE autoantibodies may play an interfering role.
Recently , dihydrotestosterone ( DHT ) has also been identified as a predictor for peripheral vascular and ischemic heart disease.
Recently , dividing the pancreas by stapler is a commonly performed technique , however , POPF still occurs.
Recently , DPP-4 has been shown to cleave multiple peptides , and blockade of DPP-4 could exert diverse biological actions in GLP-1- or GIP-independent manner.
Recently , elevated serum FGF21 levels have also been reported in subjects with coronary heart disease or carotid artery plaques.
Recently , emerging evidence suggests that MAPKs also promote the development of cardiac arrhythmias.
Recently , endoscopic procedures including surgery , intervention , and examination have been widely performed.
Recently , few reports showed TDP-43 changes in cognitively normal elderly.
Recently , frailty has increasingly been recognized as a common and important HIV-associated non-AIDS ( HANA ) condition.
Recently , GDF11 has been identified as playing a role during aging , however there are conflicting reports as to the nature of this role.
Recently , genetic analyses using various animal models have identified molecules that are crucial for aging.
Recently , genome-wide association studies ( GWAS ) have been used to investigate AD pathogenesis.
Recently , GH therapy has also been shown to induce cell genesis in the adult brain.
Recently , high-through put analysis reveals that EWSAT1 is also highly expressed in human nasopharyngeal carcinoma ( NPC ) .
Recently , high-through put analysis reveals that LOC100129148 is highly expressed in NPC.
Recently Hip structure ( strength ) analyses have become available during standard DXA measurements.
Recently , however , it has become apparent that this process entails more than a simple cessation of cell growth.
Recently , however , there has been a burgeoning of interest in telomere dynamics in healthy organisms.
Recently , HSP70 has been shown to bind specifically to an amino-terminal sequence of a human diffusible survival evasion peptide ( DSEP ) , dermcidin.
Recently , IgD STUDY QUESTION : Are telomere length and telomerase activity associated with biochemical primary ovarian insufficiency ( POI ) ?
Recently , increasing public recognition , together with the development of more integrated medical and psychological healthcare services has resulted in significant improvements.
Recently , inflammation has been strongly associated with insulin resistance and diabetes.
Recently in Japan , the decline of maternal HCMV seropositivity may increase the risk of intrauterine infection.
Recently , injectable dermal fillers have become important alternatives to surgical procedures for the correction of facial wrinkles.
Recently in Neuron , Beckervordersandforth et al.
Recently , interventions utilising meditation-based techniques have been developed with the aim of reducing psychological distress among dementia caregivers.
Recently , in the field of forensic medicine the number of unidentified cadavers has increased due to mass disasters and international terrorism.
Recently , it has also been found to regulate the balance between osteoblast and adipocyte differentiation in bone marrow mesenchymal stem cells.
Recently , it has become possible to detect CMIs in vivo.
Recently , it has become possible to measure the carotenoids non-invasively and online using resonance Raman spectroscopy.
Recently , it has been realized that age-related changes in other tissues besides articular cartilage may also contribute to OA development.
Recently it has been recognized that abnormalities of muscle may be an intrinsic aspect of AD and might contribute to the pathophysiology.
Recently , it has been reported that arterial perfusion through the axillary artery provides sufficient antegrade aortic flow associated with fewer atheroembolic complications.
Recently , it has been reported that preclinical AD patient brains show elevated levels of oxidative damage in both nuclear and mitochondrial nucleic acids.
Recently , it has been shown that mtDNA is differentially methylated in various diseases such as diabetes and colorectal cancer.
Recently it has been shown that treatment in a specialized neurological intensive care unit alone was associated with better outcomes after ICH.
Recently , it has been suggested that the main mechanism of SC action relies on paracrine signals.
Recently , it has shown that ROS play a dual role as both deleterious and beneficial species depending on their concentration in MSCs.
Recently , it is also suggested that senescent osteocytes and their senescence-associated secretory phenotype may contribute to age-related bone loss.
Recently , it was demonstrated by quantitative mass spectrometry that RhoGDIα is heavily targeted by post-translational lysine acetylation.
Recently , it was recognized that microglia express voltage-gated ion channels , in particularly voltage-gated sodium channels ( VGSC ) .
Recently , it was shown that adaptive optics retinal imaging can resolve parietal structures of retinal arterioles in humans in vivo.
Recently , leucine-rich repeat kinase @number@ ( LRRK2 ) has been identified as a causative gene for autosomal dominantly inherited familial PD cases.
Recently licensed quadrivalent influenza vaccines ( QIVs ) containing the two B lineages should address this issue.
Recently , many age-related DNA methylation biomarkers in peripheral whole blood have been identified.
Recently , many efforts are focused on reprogramming cell fates by non-viral and non-integrating chemical approaches.
Recently , many healthcare or health monitoring systems are proposed to improve life quality of the elderly in the aging process.
Recently , many researchers have used graph theory to study the aberrant brain structures in Alzheimer's disease ( AD ) and have made great progress.
Recently , mice lacking osteocalcin or its receptor were reported to be subfertile with low testosterone and high luteinizing hormone concentrations.
Recently , microRNAs ( miRNAs ) have emerged as important regulators of EC function by fine-tuning gene expression.
Recently , miRNAs with functions associated with aging or aging-related diseases have been studied.
Recently , mitochondria have been shown to exhibit peculiar features in pluripotent stem cells ( PSCs ) .
Recently , MOAG-4 / SERF has been identified as a class of evolutionarily conserved proteins that positively regulates aggregate formation.
Recently , more and more evidence indicated that VEGF is expressed in the neurons of the developing and adult brains.
Recently , multidimensional approaches to measuring frailty have included cognition , mood and social components.
Recently , mutations in CIT , encoding CRIK ( citron rho-interacting kinase ) -a component of the central spindle matrix-were added.
Recently , mutations in POFUT1 , which encodes protein O-fucosyltransferase @number@ were also reported to be responsible for DDD.
Recently , mutations in PYCR1 have been linked to cutis laxa with progeroid features.
Recently , neural oscillations , especially gamma oscillation ( > 30 Hz ) has been paid attention in the Systems Neuroscience.
Recently , new cellular / physiologic roles of G6PD have been discovered.
Recently , new evidence has revealed that vitamin D affects chronic diseases such as autoimmune diseases , cardiovascular diseases and certain cancers.
Recently , new protocols , including use of pediatric protocols in young adults , have improved survival in clinical trials.
Recently , new topical NSAIDs have been approved for topical ophthalmic use , allowing for greater drug penetration into the vitreous.
Recently , nucleolus-associated chromosomal domains ( NADs ) have been discovered , yet their precise genomic organization and dynamics are still largely unknown.
Recently , numerous studies of aging and longevity have been performed using short-lived animals , however , longevity mechanisms remain unknown.
Recently , numerous technological advantages have led to the evolution of DNA microarrays and microarray-based techniques , revealing the genomic modification and all transcriptional activity.
Recently , one interesting observation is that the protein abundance is higher in senescent cells than that in young cells.
Recently , our laboratory found that posttranslational modification of histone deacetylase ( HDAC ) @number@ is actively involved in the development of vascular calcification.
Recently , phosphorylation of H2A.X was proposed as a sensitive biomarker of aging.
Recently , plasma miRNAs have been reported to be sensitive and specific biomarkers of various tissue injuries and pathological conditions.
Recently published data demonstrate major demographic changes and disease trends evolving in the Asia-Pacific.
Recently published data strongly suggest an independent function of the FMR1 gene on ovaries.
Recently recognised as potent antioxidants , reactive persulfide and polysulfide species are biosynthesised by cystathionine β-synthase and cystathionine γ-lyase.
Recently released guidelines define CKD as abnormalities of kidney structure or function , present for more than @number@ months.
Recently , replicative senescence has been shown to be associated with highly reproducible epigenetic modifications.
Recently , research in drug development is focused on new and more \ "physiological \ " approach to balance bone remodeling.
Recently , resting energy expenditure ( REE ) has been proposed to link age-dependent CL with developmental changes.
Recently , results of an in vivo guinea pig study indicated a therapeutic effect of physostigmine given after soman.
Recently , revolumization for age-related lipoatrophy has become increasingly popular.
Recently , robotic technology , especially socially assistive robotics has been investigated to address the physical , cognitive , and social needs of older adults.
Recently , ROS have been found to be associated with tumor metastasis involving the processes of tumor cell migration , invasion and angiogenesis.
Recently , RPE cells were generated from hiPS cells.
Recently , Scottish country dance ( SCD ) was reported as being a beneficial form of physical activity for functional ability in older females.
Recently , several causative genes have been identified in mendelian forms of PD.
Recently , several new B cell populations have been characterized which were suggested to develop in an age-dependent manner.
Recently , several novel markers of senescence associated with the plasma membrane have been identified.
Recently , several observational tools have been developed in order to assess pain behaviors in non-communicative patients.
Recently , several positron emission tomography ( PET ) radiopharmaceuticals targeting abnormal conformations of the tau protein have been developed.
Recently , several studies described resveratrol as an anti-aging compound.
Recently , several studies have investigated the effect of various therapeutical interventions on ADMA plasma concentrations.
Recently , SGLT2 inhibitors have been demonstrated to be effective for the treatment of patients with type @number@ diabetes ( T2D ) .
Recently , splice variants of the CB1R have been identified in humans.
Recently , SSCs were shown to be reprogrammed into multipotent SSCs ( mSSCs ) .
Recently , statins have been extensively investigated as potential therapeutic agents capable of slowing the progression of vascular and valvular calcification.
Recently , studies have shown a different genetic susceptibility in cardiovascular toxicity induced by therapy with PBCs.
Recently , studies using crystallography and computational chemistry have provided information on the structure and conformational changes related to HDAC-mediated recognition events.
Recently , studies using genetically modified mice have shown that the in vivo expression profile of the Epo gene changes dramatically during development.
Recently , such treatments have become available in at-home setting due to advent of self-application NAFT devices.
Recently , the cardio-ankle vascular index ( CAVI ) has been reported to be a highly reproducible arterial stiffness parameter in OSA patients.
Recently , the cardio-ankle vascular index ( CAVI ) was developed as a new parameter reflecting arterial stiffness and providing an index of vascular status.
Recently , the connection between autophagy and the hedgehog ( HH ) signaling pathway has been studied.
Recently , the Dimensional Apathy Scale ( DAS ) was developed to assess apathy as multifaceted construct , independent of physical disability.
Recently , the Dutch government tightened the criteria for older adults to be admitted in a nursing home.
Recently , the first genome wide association study was performed using only FTLD patients with a pathologically confirmed TDP-43 pathology.
Recently , the focus of anti-aging research has expanded from endocrine signaling pathways to effects on regulatory gene networks.
Recently , the focus of postoperative neurological research has shifted from managing cardiopulmonary bypass to patient-related factors.
Recently , the functional and redox state of peripheral immune cells has been proposed as a useful tool for measuring the progression of AD.
Recently , the Global Lung Function Initiative ( GLI ) expanded LMS spirometric Z scores to multiple ethnicities.
Recently , the hormonal regulation of iron metabolism has been elucidated.
Recently , the HyperSPHARM algorithm was proposed to parameterize multiple disjoint objects in a holistic manner using the 4D hyperspherical harmonics.
Recently , the impact of metabolic abnormalities on ALT variation has raised concern due to the worldwide obesity epidemic.
Recently , the inflammation induced after mechanical stress and the subsequent response of ligamentum flavum ( LF ) cells have been implicated in LFH pathology.
Recently , the Movement Disorder Society ( MDS ) proposed diagnostic criteria for MCI in PD ( PD-MCI ) .
Recently , the new concept of sarcopenic obesity has emerged , reflecting a combination of sarcopenia and obesity.
Recently , the nine hallmarks of ageing have been defined as cell-autonomous and non-autonomous pathways involved in ageing.
Recently , the number of youth who are engaged in formal competition has increased.
Recently , the perioperative administration of dexmedetomidine and the provision of remote ischemic preconditioning have been studied to potentially limit the development of perioperative AKI.
Recently , there has been more focus on conservative ( nondialytic ) care as a legitimate option , particularly for elderly patients.
Recently , the role of growth factors in the pathogenesis of neonatal PH has attracted much attention.
Recently , the spotlights have turned to senescent cells as being a culprit for aging.
Recently , the transradial access has been intensively employed as an alternative means for diagnostic and interventional procedures.
Recently , the Women's Health Initiative study found that conjugated equine estrogens , the most commonly prescribed HT , do not benefit cognition.
Recently this postural-cognitive relationship was addressed with a new approach.
Recently , tissue-specific stem cell therapy has attracted public attention as a next-generation therapeutic reagent.
Recently tri-axial accelerometers have been validated for ambulatory activity monitoring in older adults.
Recently , two bone-targeted agents have been approved in the prevention of SREs in advanced RCC : zoledronic acid and denosumab.
Recently , two immune checkpoints , PD-1 and PD-L1 , have emerged as important targets for immunotherapy.
Recently , two longitudinal studies have demonstrated a cause and effect relationship between MetS and WBC counts among middle-aged adults.
Recently , unique variations in the same gene have been reported in familial and sporadic Japanese cases of amyotrophic lateral sclerosis ( ALS ) .
Recently , unmetabolized FA in plasma raised public health concerns ; but numerous studies used FA for disease prevention.
Recently , variants in FOXO3A have consistently been associated with human longevity in various populations worldwide.
Recently , variants in TREM2 were also associated with frontotemporal dementia and Alzheimer's disease.
Recently , very unique characteristics of rikkunshito have been unveiled ; oral administration of rikkunshito potentiates orexigenic action of ghrelin through several different mechanisms.
Recently , VGF mRNA was detected in peripheral leukocytes.
Recently we and others demonstrated that pan-mTOR inhibitors , known also as dual mTORC1 / C2 inhibitors , suppress senescent phenotype.
Recently , we could demonstrate that subjects suffering from current symptoms of insomnia exhibited significantly decreased serum BDNF levels compared with sleep-healthy controls.
Recently we demonstrated that DigiFab ( Fab fragments of affinity-purified ovine digoxin antibody ) restores PE-induced inhibition of Na / K-ATPase in erythrocytes ex vivo.
Recently , we demonstrated that gene ablation of mitochondrial manganese superoxide dismutase and aldehyde dehydrogenase-2 markedly contributed to age-related vascular dysfunction and mitochondrial oxidative stress.
Recently we demonstrated that one of the markers of p21- and p16-initiated senescence is MEK-dependent hyper-elevation of cyclin D1.
Recently , we demonstrated the nearly ubiquitous presence of brain-reactive autoantibodies in human sera.
Recently , we described that TAT from cardiomyopathy ischemic subjects has angiogenic properties.
Recently , we discovered ABT-263 , a potent and highly selective senolytic agent , by screening a library of rationally-selected compounds.
Recently , we established Tet-mev-1 conditional transgenic mice using our uniquely developed Tet-On / Off system , which equilibrates transgene expression to endogenous levels.
Recently , we had also summarized the potential pathways associated with HA regulation in human MSCs.
Recently , we have demonstrated the anti-ageing activity of telomerase by forcing telomerase expression in mice with augmented cancer resistance.
Recently , we have shown a similar effect in animals.
Recently , we implemented this model by studying centenarians ' offspring and offspring of non-long lived parents.
Recently , we proposed the idea that exercise can be regarded as a drug.
Recently we published the initial subset of imaging findings for specific regions in a cohort of individuals with autosomal dominant Alzheimer's disease.
Recently , we reported on the anti-ageing effects of K6PC-5.
Recently , we reported on the selection of D-enantiomeric , Abeta-binding peptides D1 and D3.
Recently , we reported that a low serum level of sulfatide in hemodialysis patients might be related to the high incidence of cardiovascular diseases.
Recently , we reported that Klotho recombinant protein attenuated apoptosis and cellular senescence in endothelial cells , but the mechanism remained unclear.
Recently we reported that plasma levels of marinobufagenin ( MBG ) , a bufadienolide vasoconstrictor CTS , are increased four-fold in patients with severe preeclampsia.
Recently , we reported the syntheses of a number of novel phenolic antioxidants for possible application in food industry.
Recently , we showed that the same allele might be involved in preservation of glucose metabolism , body composition and blood pressure during ageing.
Recently , widespread interest has grown regarding the apparent protective effects of melatonin on smooth muscle dysfunction.
Recent meta-analyses have reached contrasting conclusions regarding cardiovascular adverse events associated with testosterone therapy.
Recent molecular data suggest that certain antioxidants may contribute towards oncogenesis.
Recent neuroscientific research has demonstrated that both healthy and pathological aging induces alterations in the co-operative capacity of neuronal populations in the brain.
Recent outbreaks of dengue and chikungunya have been reported in Kenya.
Recent outcomes showed prevailing negative social stereotype to ageing in CR.
Recent papers in the literature have shown better functional outcomes with a primary hip replacement over other treatment modalities.
Recent patents on the field have addressed new issues on how endocrine control should be managed along with asthma therapeutics.
Recent population studies indicate that mortality may be increasing over the past decade.
Recent population studies suggest an intriguing inverse relationship between several types of cancer and neurodegenerative diseases , including Alzheimer's disease.
Recent preclinical results with a pharmacological prolongevity agent ( rapamycin ) provide a proof-of-concept that such an approach is feasible in human populations.
Recent progress in basic research has revealed certain similarities between processes of bone calcification and calcifications of vascular tissues which contribute to several cardiovascular diseases.
Recent publications suggested the importance of the magnitude of longitudinal decline of testosterone from baseline.
Recent publications were reviewed to elucidate the connection between aging and OA.
Recent report has demonstrated the association of senescent phenotypic change with osteoblastic trans-differentiation in VSMC.
Recent reports have indicated that miRNAsact as key modulators of cellular senescence by targeting critical regulators of the senescence pathways.
Recent reports have shown that image acquisition parameters may influence VBM results.
Recent reports have shown that statin ( HMG-CoA reductase inhibitors ) may have the potential to inhibit inflammatory arthritis.
Recent reports have shown the antidiabetic effect of Moringa oleifera from various parts of the world.
Recent reports indicate that gastric mucosa of aging humans and experimental animals exhibits increased susceptibility to injury and delayed healing.
Recent reports indicate that inflammatory responses occurring within the central nervous system contribute to the pathogenesis of ALS.
Recent reports of functional and anatomical studies have provided evidence that aberrant neural connectivity lies at the heart of many mental disorders.
Recent reports on cocoa are appealing in that a food commonly consumed for pure pleasure might also bring tangible benefits for human health.
Recent reports proposed a role for autophagy in clearance of diffuse ubiquitinated proteins delivered by p62 / SQSTM1.
Recent reports show a decline with advanced age ( > 64 years ) using a variety of motor simulation tasks.
Recent reports showed that level of @number@ hmC was altered in various types of cancers.
Recent reports suggested that microRNA ( miRNA ) profiling of biological fluids has emerged as a diagnostic tool for several pathologic conditions.
Recent reports suggested that the process of NFT formation , but not NFT itself , is involved in neuronal dysfunction.
Recent reports suggested that α-synuclein in multiple system atrophy ( MSA ) has similar pathogenic mechanisms as the prion protein.
Recent reports suggested the importance of modifiable factors in the testosterone decline in addition to aging.
Recent research found that intermittent dosing can reduce hypercalcemia rates.
Recent research has claimed that a novelty dimension is needed to represent the cognitive emotion structure over and above valence , power and arousal.
Recent research has demonstrated that patients with Alzheimer's disease ( AD ) show deficits in semantic processing when compared to cognitively healthy individuals.
Recent research has focused on natural compounds possibly endowed with antiaging effects.
Recent research has shed light on whether and how ageing influences these circuits , providing an interdisciplinary account of how ageing can alter decision making.
Recent research has shown that personality traits continue to develop throughout the life span , but most profound changes are typically found during young adulthood.
Recent research has used source estimation approaches to identify spatially distinct neural configurations in individuals with chronic , subjective tinnitus ( TI ) .
Recent research in chemotherapy has prioritized overcoming the multidrug resistance ( MDR ) of cancer cells.
Recent research indicates that many individuals have GFR values less than @number@ ml / min / 1.73 m² without other manifestations of CKD.
Recent research in mice showed that exercising mice had higher levels of telomerase , an enzyme that helps maintain telomere length , than nonexercising mice.
Recent research in the geography of health care moves beyond distributive concerns focusing more sensitively on the nature of health care settings.
Recent research reveals an age-related increase in positive autobiographical memory retrieval using a number of positivity measures , including valence ratings and positive word use.
Recent research shows that declining oocyte quality with age is not inevitable in nematodes , and similar signals might regulate reproductive aging in women.
Recent research studies have tested interventions designed to improve communication quality and outcomes between providers and families of patients in the ICU.
Recent research suggests that epidemiological forces in religion and health can have opposed effects.
Recent research suggests that frailty may be reversible , which could result in significant improvement in public health.
Recent research suggests that Sense of Coherence positively affects quality of life.
Recent research suggests that the activation of the caudate nucleus plays an important role in consumer behavior.
Recent research suggests that the crucial link between Aβ aggregation and tauopathy is somehow disengaged in aged monkeys.
Recent research with older adults has provided evidence suggesting both intact and deficient memory suppression.
Recent results from high-throughput whole-genome expression or copy number studies have demonstrated extensive genetic diversity between cases and within individual GC.
Recent scientific advances suggest that slowing the aging process ( senescence ) is now a realistic goal.
Recent statistics indicate that the human population is ageing rapidly.
Recent studies about brain network have suggested that normal aging is associated with alterations in coordinated patterns of the large-scale brain functional and structural systems.
Recent studies also indicate that microRNAs play important roles in mediating sex-specific stroke outcome by regulating stroke-related genes.
Recent studies also show that delirium strongly predicts future new-onset dementia , as well as accelerating existing dementia.
Recent studies and future directions will be focused in this review regarding the molecular functions of tocopherols.
Recent studies are focused on morbidity related to cardiopulmonary complications , bone health and ageing within the sarcoidosis population.
Recent studies based on high-resolution imaging have shown microarchitectural deterioration of trabecular bone even in premenopausal women presenting with a wrist fracture.
Recent studies cast doubt on the value of right ventricular pacing alone for cardiac resynchronization and provide a rationale for biventricular pacing.
Recent studies correlated aneuploidy with early aging , senescence and organ dysfunction.
Recent studies documenting the use of cell reprogramming for the generation of multipotent neuronal precursors as well as functional BFCN and DA neurons are reviewed.
Recent studies have additionally found a correlation between psychological stress , telomere length , and health outcome in humans.
Recent studies have addressed some of these questions.
Recent studies have also examined compensatory processes that take place during the early phase of the disease.
Recent studies have also identified multifaceted protective roles for Sirt1 against cellular senescence and stress in the neural , cardiovascular , and renal systems.
Recent studies have also suggested that HSV-1 contributes to the appearance of the biochemical anomalies characteristic of AD brains.
Recent studies have begun to elucidate molecular mechanisms underlying the beneficial effects of exercise.
Recent studies have begun to elucidate the consequences of aging on TLR function in human cohorts and add to existing findings performed in animal models.
Recent studies have begun to look at melatonin release from the GI epithelium using real-time electrochemical detection methods.
Recent studies have consistently shown their therapeutic potential in various human disease models.
Recent studies have demonstrated aberrant CpG island methylation ( CIM ) in chronic inflammation , aging and cancer.
Recent studies have demonstrated a mechanistic link between Wnt signaling and premature aging or aging-related phenotypes.
Recent studies have demonstrated a relationship between cancer and obesity.
Recent studies have demonstrated relationships between the disturbance of circadian rhythm and the development of lifestyle-related diseases.
Recent studies have demonstrated that human telomerase is associated with pathological mechanisms of AD.
Recent studies have demonstrated that light may be a contributing factor for the death of retinal ganglion cells in certain situations.
Recent studies have demonstrated that low-molecular-weight HA ( LMW HA ) may show a certain proinflammatory activity.
Recent studies have demonstrated that senescent cells also accumulate in many tissues in vivo and contribute to age-related pathologies.
Recent studies have demonstrated that senescent cells express a senescence-associated secretory phenotype ( SASP ) .
Recent studies have demonstrated that some types of exercise affect the expression and activity of sirtuins in several tissues.
Recent studies have demonstrated that the DNA methylome changes with age.
Recent studies have demonstrated that the expression of NRF2 protein is upregulated in several human malignancies and is associated with worse prognosis in these patients.
Recent studies have demonstrated that the obese metabolic state can be improved by ablating certain inflammatory signaling pathways.
Recent studies have demonstrated that young adults can voluntarily suppress information from memory when directed to.
Recent studies have demonstrated the presence of Aβ plaques in the eyes of AD subjects , which is positively associated with their brain Aβ burden.
Recent studies have focused on the impact of glycosylation and sialylation on ion channels , particularly for voltage-gated potassium and sodium channels.
Recent studies have found that de novo mtDNA mutations are suppressed in the female germ line ; despite this , mtDNA heteroplasmy is remarkably common.
Recent studies have highlighted the modulation of this complex pathway as a putative therapeutic strategy.
Recent studies have identified a rare coding variant ( p.R47H ) in TREM2 that confers a high risk for Alzheimer's disease ( AD ) .
Recent studies have identified biomarkers of chronological age based on DNA methylation levels.
Recent studies have identified circulating Hsp as an important mediator in inflammation - the effects of low-grade inflammation in the aging process are overwhelming.
Recent studies have identified RPCs in the retina , which may have important implications in health and disease.
Recent studies have implicated memory CD4 T cells in heterotypic immunity in animal models and in human challenge studies.
Recent studies have indicated the age-related defect of autophagy signaling in skeletal muscle , whereas autophagic activation occurs in cachectic muscle.
Recent studies have indicated the possible involvement of GRK , primarily GRK2 and GRK5 , dysfunction in the pathogenesis of AD.
Recent studies have investigated changes in the human brain network organization during the normal aging.
Recent studies have investigated potential interventions to overcome this anabolic resistance.
Recent studies have laid the basis for development of exosomes-based techniques to screen / diagnose lung cancers.
Recent studies have linked constitutive telomere length ( TL ) to aging-related diseases including cancer at different sites.
Recent studies have linked dopamine to differences in behavior and brain activity in normal individuals.
Recent studies have looked into the acute effect of exercise on the brain using standardized low-resolution brain electromagnetic tomography ( sLORETA ) .
Recent studies have pointed out dysfunction and histopathological changes of the choroid plexuses ( CPs ) with aging.
Recent studies have pointed to protein S-nitrosylation as a critical regulator of cellular redox homeostasis.
Recent studies have proposed a close relationship between oxidative stress and energy metabolism-associated disease.
Recent studies have raised the question of whether non-viable probiotic strains can confer health benefits on the host by influencing the immune system.
Recent studies have reported a higher than anticipated frequency of large clonal autosomal mosaic events > 2 Mb in size in the aging population.
Recent studies have reported declining incidence and mortality for other major heart diseases.
Recent studies have reported several genetic , health , and aging interaction effects in predicting cognitive performance and change.
Recent studies have reported that leukocyte telomere length ( LTL ) is longer in offspring of older fathers.
Recent studies have reported that oxidative stress is involved in obesity , in addition to many other human diseases and aging.
Recent studies have reported that the myocardial triglyceride ( TG ) content is associated with aging , metabolic disorders and cardiac dysfunction.
Recent studies have revealed a key neuronal maintenance and protective function for nicotinamide mononucleotide adenylyl transferases ( NMNATs ) .
Recent studies have revealed an important role for LTBP-4 in elastogenesis.
Recent studies have revealed a strong relationship between gait and executive functions in healthy and pathological aging.
Recent studies have revealed disruptions in the coordination of large-scale functional brain networks such as the default mode network in advanced aging.
Recent studies have revealed that aging-associated changes in chondrocytes are important causative factors of OA.
Recent studies have revealed that cells from WS patients can be successfully reprogrammed into induced pluripotent stem cells ( iPSCs ) .
Recent studies have revealed that mitochondrial structural remodeling through division and fusion is critical to the organelle's function.
Recent studies have revealed that sensitivity of baroreceptor reflex is impaired in metabolic syndrome and aging.
Recent studies have revealed various O-mannosyl glycan structures , which can be classified as core M1 , core M2 , and core M3 glycans.
Recent studies have shown age-related deficits in learning subtle probabilistic sequential relationships.
Recent studies have shown that aging has a large impact on connectivity within and between functional networks.
Recent studies have shown that aging , psychiatric and neurologic diseases , and dopaminergic blockade all result in altered brain network efficiency.
Recent studies have shown that COPD patients have enhanced expression of senescence-associated proteins in the lung and in the peripheral circulation compared to healthy controls.
Recent studies have shown that C-terminus ( CT ) truncation and propagation of α-syn play a role in the pathogenesis of PD / DLB.
Recent studies have shown that dysregulation of specific microRNAs is critically involved in the development of Alzheimer's disease ( AD ) .
Recent studies have shown that elements of the oxidative stress response and the UPS are linked on many levels.
Recent studies have shown that epigenetic modifications play a key role in the regulation of the molecular pathogenesis of gliomas.
Recent studies have shown that episodic retrieval processes are involved in the effect.
Recent studies have shown that IL-15 does in fact play an appreciable role in CD4 memory T cells under physiological conditions.
Recent studies have shown that impairment in executive function ( EF ) is common in patients with amnestic mild cognitive impairment ( aMCI ) .
Recent studies have shown that increasing the number of chews before swallowing reduces meal size in young adults.
Recent studies have shown that sirtuin-1 ( Sirt1 ) plays an important role in the development of endothelial senescence.
Recent studies have shown that tau aggregates may form distinct structural conformations , known as tau strains.
Recent studies have shown that the expression and regulation of TERRA are dynamically controlled by each chromosome end.
Recent studies have shown that the progression of these diseases is accelerated during aging in both sexes.
Recent studies have shown that tissue-specific stem cells ( SCs ) found throughout the body respond differentially to DNA damage.
Recent studies have strongly implicated cell-to-cell transmission of misfolded proteins as a common mechanism for the onset and progression of various neurodegenerative disorders.
Recent studies have suggested an important role for insulin signaling in the regulation of myocardial autophagy.
Recent studies have suggested that acupuncture may be a feasible alternative to traditional sleep medicine for treating sleep disturbance.
Recent studies have suggested that CK2 downregulation is associated with aging.
Recent studies have suggested that DNA methylation is implicated in age-related changes in gene expression as well as in cognition.
Recent studies have suggested that exposure to prolonged psychological stress may alter an individual's physiological responses , and contribute to morbidity and mortality.
Recent studies have suggested that G-protein-coupled receptor kinase @number@ ( GRK5 ) deficiency plays a significant role in the pathogenesis of early Alzheimer's disease.
Recent studies have suggested that ikigai impacts on mortality.
Recent studies have suggested that micronutrients may influence telomere length.
Recent studies have suggested that pulmonary fibrosis may be driven by accelerated aging-related mechanisms.
Recent studies have suggest that masticatory ( chewing ) function is useful for maintaining neurocognitive function in the elderly.
Recent studies have uncovered important aging clues , including free radicals , inflammation , telomeres , and life span pathways.
Recent studies highlight the interplay between cilia and autophagy , a conserved cellular process responsible for intracellular degradation.
Recent studies , however , noted that the predictive validity varies across population subgroups.
Recent studies identified high levels of oxidized lipid-free apoA-I in atherosclerotic plaques.
Recent studies identified the blood brain barrier as hotspot of damage due to neurodegeneration.
Recent studies implicate amyloid beta accumulation , defects of proteolysis , and immune system abnormalities.
Recent studies implicated the role of MMPs in acute neuroinflammatory damage as well as in chronic neurodegeneration.
Recent studies implicate the endothelial-mesenchymal transition in contributing to the phenotypic drift of mineralizing vascular progenitors.
Recent studies implicate the immediate-early response transcription factor Egr-1 in the pathogenesis of fibrosis.
Recent studies implicate the reactive oxygen species ( ROS ) -generating enzyme , NADPH oxidase @number@ ( Nox4 ) in cellular senescence.
Recent studies indicated that extracellular tau uploaded from neurons causes synaptic dysfunction and contributes to tau pathology propagation.
Recent studies indicate that activation of autophagy is defective in aging and osteoarthritis ( OA ) , contributing to cell death and tissue damage.
Recent studies indicate that aging is associated with dysfunctional changes in pain modulatory capacity , potentially contributing to increased incidence of pain in older adults.
Recent studies indicate that BACE1 elevation is associated with axonal and presynaptic pathology during plaque development.
Recent studies indicate that glucose deprivation can greatly enhance metformin-mediated inhibition of cell viability , but the molecular mechanism involved in this inhibition is unclear.
Recent studies indicate that non-coding RNAs which are closely associated with cancer are abnormally expressed under hypoxia.
Recent studies indicate that nutrient-dependent changes in stem cell populations play an important role in these effects.
Recent studies indicate that reactive oxygen species ( ROS ) play important roles in HGPS phenotype progression.
Recent studies indicate that SIRT2 plays an important role in metabolic homeostasis.
Recent studies indicate that socioeconomic inequalities in health extend into the elderly population , even within the most highly developed welfare states.
Recent studies in diverse organisms have also delineated emerging pathways , which collectively or independently contribute to ageing.
Recent studies in mice have identified single molecules that can delay multiple diseases of aging and extend lifespan.
Recent studies in older adults and people with PD suggest dance interventions provide various motor benefits.
Recent studies of factors contributing to α-synuclein toxicity and its disruption of downstream cellular pathways have expanded our understanding of disease pathogenesis in synucleinopathies.
Recent studies of the heart show that the interstitium informs organogenesis and responsiveness to pathological stimuli through continuous bidirectional cross-talk between cardiomyocytes and non-cardiac cells.
Recent studies on development of visual working memory ( VWM ) predominantly focus on VWM capacity and spatial-based information filtering in VWM.
Recent studies on mammalian FoxO have established a direct role for this transcription factor family in cellular proliferation , oxidative stress response , and tumorigenesis.
Recent studies on the etiology of schizophrenia and autism spectrum disorders revealed a profound impact of neurodevelopmental disturbances on disease predisposition , onset and progression.
Recent studies provided compelling evidence that vascular calcification is associated with inflammatory status and is enhanced by inflammatory cytokines.
Recent studies published by the National Academy of Sciences ( USA ) describe human longevity links with the month of birth.
Recent studies reported DEPDC5 loss-of-function mutations in different focal epilepsy syndromes.
Recent studies report that the majority of older adults wish to live in their own homes , for as long as possible.
Recent studies report that there does not appear to be a single prototypical pattern of neuropsychological impairment associated with HIV , but includes diverse manifestations.
Recent studies reveal 2-aminoadipic acid ( 2-AAA ) is both elevated in subjects at risk for diabetes and mechanistically linked to glucose homeostasis.
Recent studies revealed its ability to up- and downregulate a large number of human genes including those that are critical for neuronal development and maintenance.
Recent studies revealed that Cisd2 may function as an autophagy regulator involved in the Bcl-2 mediated regulation of autophagy.
Recent studies revealed that CR could influence the lineage determination of stem cells including MSCs.
Recent studies revealed that the quality of HDL and LDL cholesterol may be more important than their serum levels.
Recent studies reveal that a disturbed balance of their enzymatic activities is the first insult in brain aging and age-related diseases.
Recent studies reveal that an integral part of the cellular management of misfolded proteins is their spatial sequestration into several defined compartments.
Recent studies reveal that S-nitrosylation-mediated redox signaling plays an important role in several biological processes essential for neuronal differentiation and maturation.
Recent studies show a prevalence of sensitization of 3-10% in the total population of Europe.
Recent studies showed that differences in amyloid conformation from different brain regions lead to differing toxicity.
Recent studies showed that SOM modulates olfactory processing , suggesting that alterations in SOM levels participate to olfactory deficits in AD.
Recent studies show that both metabolic syndrome and benign prostatic hyperplasia are associated with blood vessel injury , hyperinsulinemia and over-activity of the sympathetic nerve.
Recent studies show that n-3 PUFAs display neuroprotective properties and exert beneficial effects on the cognitive function with aging.
Recent studies show the various clinical presentations that may delay diagnosis up to several years in absence of typical bullous presentation.
Recent studies suggest a correlation between cochlear radiation dose and hearing preservation.
Recent studies suggest a link between age-related decreases in dehydroepiandrosterone ( DHEA ) concentrations and dementia in the general population.
Recent studies suggest alternative radiological diagnostics such as ultrasound and scintigraphy can detect and differentiate between different forms of SBD.
Recent studies suggest an involvement of exosomes that originate from the endosomal pathway in viral release.
Recent studies suggest cell cycle events as well as reactive oxygen species ( ROS ) contribute to vascular cell dysfunction associated with aging.
Recent studies suggest detectable CMV DNA in peripheral monocytes as a better indicator for this persistent viral infection than anti-CMV IgG serology.
Recent studies suggest it has an important cognitive role , although there is no consensus about what this is.
Recent studies suggest that adaptive immunity is necessary , but not sufficient , for host defense against mycobacteria.
Recent studies suggest that adeno-associated virus ( AAV ) -expressed TERT in adult mice can increase life span and health span.
Recent studies suggest that ALDH2 dysfunction is also associated with Fanconi anemia , pain , osteoporosis , and the process of aging.
Recent studies suggest that allergic rhinitis is highly prevalent in the elderly population , but is underdiagnosed and undertreated.
Recent studies suggest that CDC42 is a potent tumor suppressor in different tissues and is related to aging processes.
Recent studies suggest that chronic psychological stress may accelerate aging at the cellular level.
Recent studies suggest that common cognitive processes and neuroanatomical substrates underlie the ability to remember the past and imagine the future.
Recent studies suggest that disruption or alteration of taste bud homeostasis may contribute to taste dysfunction associated with disease and aging.
Recent studies suggest that exercise may improve NAFLD through enhancing autophagy.
Recent studies suggest that improving nutritional status for macronutrients and micronutrients may reduce the risk of frailty.
Recent studies suggest that individual hippocampal subregions perform distinct cognitive operations and are differentially targeted by aging and disease.
Recent studies suggest that micronutrients , such as vitamin D , folate and vitamin B12 , are involved in telomere biology and cellular aging.
Recent studies suggest that neutrophils also regulate T cell function and , like macrophages , neutrophil function is modulated with aging.
Recent studies suggest that OSAS may exacerbate cognitive functioning in dementia and that CPAP therapy can be applied to these patients and improve cognitive functioning.
Recent studies suggest that PAI-1 is not only a marker but also a key mediator of cellular senescence and organismal aging.
Recent studies suggest that red cell distribution width ( RDW ) has prognostic significance in these patients.
Recent studies suggest that sleep spindles and slow waves play a role in brain plasticity mechanisms and are associated with cognitive performance.
Recent studies suggest that some KA patients engage in medical tourism and receive medical care in their home country.
Recent studies suggest that subjects with hypothyroidism under therapy with levothyroxine ( L-T4 ) might develop oxidative stress.
Recent studies suggest that synaptic activity is one of the most important factors that regulate Aβ levels.
Recent studies suggest that testosterone threshold varies by symptoms and among individuals.
Recent studies suggest that the cortisol level influences the expression of the hPER1 clock gene which is involved in the generation of biological rhythms.
Recent studies suggest that the two functions dissociate in long-term memory ( LTM ) .
Recent studies suggest that UPR pathways play pivotal roles in muscle stem cell homeostasis , myogenic differentiation , and regeneration of injured skeletal muscle.
Recent studies suggest that vitamin D is associated with the preservation of muscle function related to the interactions between bone and muscle.
Recent studies support a critical role for IL-7 in the maintenance of a vigorous healthspan.
Recent studies support this idea.
Recent studies using a noninvasive infrared device has demonstrated its efficacy in tightening skin in various body regions.
Recent studies using functional imaging have identified the presence of BAT activity throughout life.
Recent studies using the human brain indicate that insulin signaling is impaired in the AD brain.
Recent surveys in Western countries consistently indicate inadequate intake of nutrients such as vitamins and minerals , compared to recommendations.
Recent technological advances are enabling unprecedentedly detailed studies of the dynamics of the microbiota in animal models and human populations.
Recent technological advances that allow faster and cheaper DNA sequencing are now driving biological and medical research.
Recent technological developments in high-throughput sequencing have enabled the genome-wide identification of estrogen-responsive genes.
Recent theories have proposed a metastructure that organizes related mental disorders into broad dimensions of psychopathology ( i.e. , internalizing and externalizing dimensions ) .
Recent therapeutic strategies show that RAGE is an important target to treat RAGE activation-associated diseases.
Recent translational human investigations have demonstrated similar exercise-induced mitochondrial signalling responses in older compared with younger skeletal muscle , regardless of training status.
Recent trends in dementia in several western countries , however , depict a gradual decline in prevalence and incidence.
Recent trials , however have failed to confirm the usefulness of this therapeutic approach , at least in unselected patients.
Recent widowhood was also associated with new use of antidepressant medication.
Recent work has demonstrated that telomeric chromatin is remodeled and telomeres are elongated by telomerase during nuclear reprogramming.
Recent work has explored a range of noninvasive neuroimaging procedures to differentially highlight alterations in the tissue microenvironment.
Recent work has focused on the role of cerebrovascular disease as one of the biological changes.
Recent work has highlighted a possible role for the early environment.
Recent work has identified several numerical competencies that predict variation in math ability.
Recent work has revealed direct links between innate immune signaling and the DNA damage response ( DDR ) .
Recent work has shown intranasal insulin can be detected in young CD-1 mice within @number@ min and is still present @number@ min after injection.
Recent work has suggested that older adults may be less susceptible to the next-day effects of alcohol relative to younger adults.
Recent work identifies some of the scaffold nucleoporins as the most extremely long-lived proteins in rat brain.
Recent work indicates that PINK1 and Parkin together maintain mitochondrial quality control by regulating mitophagy.
Recent work indicates that the metabolism and functionality of HDL particles differ greatly among HDL subspecies.
Recent work in mice and C. elegans has shed new light on the mechanisms through which developing and aging animals respond to persistent DNA damage.
Recent work in neuroscience supports the idea that variability in brain function is necessary for optimal brain responsivity to a changing environment.
Recent works have highlighted the effects of structured physical activity on miRNAs modulation.
Recent work shows how multiple-trait approaches better capture senescence as it occurs at different rates among individuals.
Recent work suggests that using alternative measures to gamma correlations might allow more accurate and informative interpretations of metamemory performance in ageing.
Recent work unveiled that DPC repair is orchestrated by proteolysis performed by two distinct metalloproteases , SPARTAN in metazoans and Wss1 in yeast.
Recent work validated that using room temperature for the storage of nucleic acids is possible if the samples are completely protected from water and oxygen.
Recent years have revealed non-cell autonomous effects of DNA damage that impact the physiological adaptations during ageing.
Recent years have seen an increasing number of studies concerned with examining personality characteristics as possible predictors of some of this variability in cognitive aging.
Recent years of scientific research have brought up different theories that attempt to explain the aging process.
Receptor expression on human fetal foreskin fibroblasts ( HFFF2 ) and human adult skin fibroblasts ( HDFa ) was examined by flow cytometry.
Receptor-mediated insulin signaling promotes DNA-binding activity of FoxM1 to regulate expression of CENP-A and polo-like kinase-1 ( PLK1 ) by modulating cyclin-dependent kinase- @date@ .
Receptors for histamine , serotonin , TNF-α and tryptase were detected both in HFFF2 and in HDFa cells.
Recessions negatively influence numeracy , verbal fluency , recall abilities , as well as the score on the omnibus cognitive indicator.
Recipients who were employed after transplantation had a significantly better posttransplant functional status than did those who were not employed.
Reciprocally , older men had a higher proportion of late-differentiated , potentially \ "senescent \ " CD57 ( + ) T cells.
Reciprocally , Trx-1 prevents stress fiber formation.
Reciprocity of inflammation , oxidative stress and neovascularization is emerging as an important mechanism underlying numerous processes from tissue healing and remodelling to cancer progression.
Reclassification indices showed that the addition of aPWV improved risk prediction ( @percent@ for 10-year CVD risk for intermediate risk ) for some subgroups.
Recognising the underlying causes and determining which approach to take to them require specialist knowledge.
Recognition , diagnosis and treatment are all complex.
Recognition memory was impaired in Tg2576 mice , whereas β-amyloid plaque depositions were observed in all these animals.
Recognition of a health problem was influenced by safety concerns , emergence of new symptoms following trauma , and treatment for other health problems.
Recognition of frailty might also help identify and optimize the management of coexisting conditions that might contribute to or be affected by frailty.
Recognition of the clinical and radiologic manifestations of these less traditional HIV-related diseases can expedite diagnosis and treatment in the ART era.
Recognition of these instances is important in identifying the high-risk population for cognitive impairment and to individualize blood pressure management for cognitive impairment prevention.
Recognition of this microbiome , largely undetectable using standard agar-based cultures , offers a new perspective on \ "UTI. \ "
Recognition of time-compressed sentences over-estimated recognition of natural fast sentences for both groups , especially for older listeners.
Recognition of words in sentences in speech-shaped noise was measured.
Recognizing and identifying an individual based on his or her face is a technical and scientific challenge and the objective of our investigation.
Recognizing causes of morbidity and mortality is important to effectively select treatments , manage symptoms and improve outcomes.
Recognizing potential risk factors along with careful attention to symptoms / LVEF measurements could minimize the occurrence of TIC in this population.
Recognizing the various presentations of bvFTD and its histological and genetic subtypes might further diagnosis , treatment , and research.
Recognizing this finding may be helpful in monitoring these patients or initiating medical therapy.
Recognizing this pattern and deciphering its origin will be necessary for the complete understanding of these major causes of death.
Recognizing this underdiagnosed syndrome is essential.
Recombinant adeno-associated virus vectors have the potential to become a promising novel therapeutic vehicles for molecular medicine in the future.
Recombinant allergens were produced as trigger-factor-fused proteins in Escherichia coli.
Recombinant CtsH could break down HDAC4 in the transfected cells and in vitro at acidic pH.
Recombinant PON1 pretreated animals exposed to sarin or soman prevented the reduction of blood O₂ saturation and pulse rate observed after nerve agent exposure.
Recombinant sirtuin @number@ comprising residues 140-747 was crystallized using the hanging-drop vapour-diffusion method.
Recombination in mitochondrial DNA ( mtDNA ) was documented more than @number@ decades ago , but the underlying molecular mechanism has remained elusive.
Recommendations and practical tips are provided that outline more judicious management of heart failure patients with lower urinary tract symptoms.
Recommendations are included.
Recommendations are made based on the results to enhance the quality of life for this vulnerable population.
Recommendations are made for developing and evaluating disaster communication materials for vulnerable populations.
Recommendations are made for examining the development of hand-use preferences and their relation to the development of other neuropsychological functions.
Recommendations are made for research and practice.
Recommendations are provided to improve the overall quality of evaluation in this area.
Recommendations are provided to reduce this and other limitations for future meta-analyses.
Recommendations are suggested that build upon the diversification success of states to further the mission of OAA in reaching high-risk older adults.
Recommendations could be improved by learning the associations of patients and ADEs as more ADE cases are accumulated through iterations.
Recommendations for CKD self-management therefore occurred within a complex regimen of recommendations for managing other diseases.
Recommendations for diagnosis and therapy were developed by an expert panel and approved after plenary discussion by the AGIHO.
Recommendations for future investigations are offered as new questions arise.
Recommendations for future research , clinical practice , and policy are provided to raise awareness of this phenomenon to help decrease its incidence.
Recommendations for future research regarding prevention and education of risks for older adults and programming suitable for a wide range of audiences are presented.
Recommendations for future studies including minimum required samples sizes are provided.
Recommendations for strategic planning and clinical practice are made that address this complex problem.
Recommendations for the clinician to screen and prevent falls in older patients are also summarized.
Recommendations for the collection and analysis of large Twitter datasets are discussed.
Recommendations for the level of adequate dietary intake of protein for older people should be informed by evidence derived from functional outcomes.
RECOMMENDATIONS : Ideally , all patients with acute stroke should be managed in a dedicated stroke unit.
Recommendations include funding for innovative grants , leveraging of federal partnerships , and targeted technical assistance.
Recommendations of maintenance and induction therapy may help to improve graft function and to design future clinical trials in the elderly.
Recommendations regarding research , practice , and advocacy are offered.
Recommendations that included a conditional word or phrase were significantly less likely to be implemented.
Recommendations were organized by outcome and graded based upon a modified version of the US Preventive Services Task Force grading system.
Recommended Dietary Allowances / Intakes have failed to adequately consider the protein requirements of the elderly with respect to function.
Recommended treatment parameters may reduce the risk of CSTF , but may not eliminate it.
Reconfiguring existing research paradigms , we review the concept of ' degeneracy' , which has divergent popular and technical definitions.
RE consisted of @number@ sets of knee extensions.
Recorded patient-dependent variables were age , gender , and edentulism status.
Recorded physical activity was low in general , with male primary care specialists being most active and female primary care physicians the least.
Recordings of electrical activity of corpus cavernosum ( EACC ) were retrospectively investigated in @number@ patients with erectile dysfunction.
Recordings were transcribed and qualitative content analysis was performed.
Records of each case were reviewed.
Records on the dates of deaths were obtained from the Provincial Office of Population Register.
Records were normalized using the 30s age records as a baseline , and studied through the various age ranges to the 90s.
Recovering interaction of endogenous rhythms from observations is challenging , especially if a mathematical model explaining the behaviour of the system is unknown.
Recovery acknowledges the role and rights of consumers and carers in planning and management of care , choice and individual strengths ( Shepherd ) .
Recovery from early stunting is possible ; however , few studies explore whether those who demonstrate linear catch-up growth experience long-term cognitive deficits.
Recovery from perturbation when walking faster was associated with better interlimb coordination , but not with better gait stability.
Recovery of MeP-P from serum was ≥68% across the validated concentration range , and contributions from matrix effects were minimal.
Recovery of these functions paralleled increased PI3K activity , although superoxide production remained low.
Recovery responses were identified using 2D cameras.
Recovery time was in average @number@ days and no long-term complications were seen.
Recovery was not less likely in participants with a history of cancer or heart disease.
RecQ helicase family members are involved in multiple DNA repair pathways , protecting the genome from incorrect recombination during mitosis and maintaining its stability.
RECQL4 enhances the binding of PolγA to DNA , thereby potentiating the exonuclease and polymerization activities of PolγA / B2.
RECQL4 is essential for the transport of p53 to the mitochondria under unstressed conditions.
RecQL4 , one of the @number@ human RecQ helicases , is a key mediator of genomic stability and its deficiency can cause premature aging phenotypes.
RECQL5-depleted cells accumulate persistent 53BP1 foci followed by γ-irradiation , indicating a potential role of RECQL5 in the processing of DSBs.
RECQL5 is one of the five human RecQ helicases , involved in the maintenance of genomic integrity.
RecQ-like DNA helicases are conserved from bacteria to humans.
Recrudesce of hypertriglyceridemic AP was higher ( P < @number@ ) .
Recruited patients are aged over @number@ years , prescribed allopurinol for symptomatic hyperuricaemia and have at least one additional cardiovascular risk factor.
Recruiting adolescents into smoking cessation programs has been challenging , and there is a lack of effective smoking cessation interventions for this age group.
Recruiting and educating practical nurses open a pathway for greater diversity in the nursing profession as well as improving patient health outcomes.
Recruitment and analysis took place iteratively until thematic saturation was reached.
Recruitment and data analyses were supported by the Center for Integrated Approaches to Complex Diseases ( SD Harlow , Director ) .
Recruitment and retention of research participants is evolving with the changing demographics of the American population , in particular its growing diversity.
Recruitment and study completion are anticipated in @date@ and @date@ respectively.
Recruitment for the study was conducted with municipal assistance.
Recruitment of hEXO1 to DNA DSB sites is dependent on the MMR protein hMLH1.
Recruitment of KLF4 to TERT promoter is reduced in PARP1-suppressed cells.
Recruitment of symptomatic older men with low testosterone levels is difficult but feasible.
Recruitment of unmedicated patients minimized the confounding effect of psychiatric medications.
Recruitment staff should be trained to understand and assist with the needs of older research volunteers.
Recruitment took place between @date@ and @date@ ; the last participant completed the study in @date@ .
Recruitment was based on self-referral , which could imply a potential selection bias.
Recruitment was from @number@ US clinical centers from @date@ through @date@ .
Rectangularization contributed less to the increase in life expectancy than longevity extension , especially for nonsmoking-related mortality among men.
Rectum biopsy confirmed amyloid deposition.
Rectus femoris elasticity was higher in males than females ( P = @number@ ) .
Recurrence- / progression-free survival was significantly lower after initial craniopharyngioma treatment with cyst aspiration compared with other therapeutic approaches.
Recurrence quantification demonstrates less recurrence isometry than copies randomized by shuffling ( novelty ) , and more consecutive isometries than shuffled copies indicating causal order.
Recurrence rate , fertility outcome and the number of pregnancies were analyzed retrospectively.
Recurrences are common after antibiotic therapy.
Recurrences occurred in @percent@ of group I and @percent@ of group II , with no significance.
Recurrent bacterial vaginosis , a difficult therapeutic challenge , can often be controlled with maintenance therapy.
Recurrent experiences with negative stereotypes combined with discrimination may make ageism a chronic stressor in the lives of older adults.
Recurrent fallers had significantly slower voluntary step execution times in both single- and dual-task conditions , especially due to a slower preparation phase.
Recurrent falls are more prevalent in older adults with cognitive impairment.
Recurrent falls impose a prompt and appropriate management with the first aim to systematically evaluate the severity of falls.
Recurrent hallucinations , fluctuation of consciousness , parkinsonism , and rapid eye movement sleep behaviour disorder were most common in DLB.
Recurrent mutations in three main genes ( SCN1A , SCN1B and GABRG2 ) have been identified that cause febrile seizures with or without epilepsy.
Recurrent readmission to hospital by frail older people places a strain on health systems and the individual.
Recurring exposure to these metabolic changes may foster diabetes and cardiovascular disease.
Recurring factors included race / ethnicity , certain care-recipient disease states , and caregiver involvement in IADLs and medically-related activities.
Recursive partitioning analysis was done to determine a subgroup of patients most likely to benefit from therapy.
Recursive partitioning analysis yielded sex- and age-specific thresholds for ceBMI that confer the greatest risk for type @number@ diabetes progression.
Recursive partitioning identified ultralow risk as the most significant predictor of good outcome.
Red and processed meat is an established risk factor for colorectal cancer ( CRC ) .
Red blood cells can be now cultured in vitro from human hematopoietic , human embryonic , or human-induced pluripotent stem cells ( hiPSCs ) .
Red blood cells ( RBC ) have been considered almost exclusively as a transporter of metabolic gases and nutrients for the tissues.
Red blood cells ( RBCs ) units are the most requested transfusion product worldwide.
Red blood cell storage lesion ( RSL ) is a multifaceted biological phenomenon.
Red blood cells transfused for \ "unspecified anemia \ " accounted for the single largest category of blood issued ( @number@ units ) .
Red blood cell volume ( RBCV ) is a main determinant of cardiorespiratory fitness in healthy individuals.
Redemption and mutual fulfillment as caregivers , reconciliations with adult children , and legacy-building as grandparents were themes associated with maintaining abstinence and reduced drinking.
Redesigning rural hospital work environments is the key to improving the quality of care for older adults.
Redesign of MOC can significantly improve patient care by applying the agreed strategies.
Red hair and mainly outdoor work or leisure raised the odds of microtopographic photoaging.
Redifferentiation of cells into their preexisting phenotype with simultaneous epigenomic rejuvenation is an interesting variation that also should be pursued.
Redirection towards less expensive forms of RRT ( peritoneal dialysis , home haemodialysis ) or kidney transplantation should decrease financial pressure.
Redistribution and loss of AF granules are among the earliest AMD changes and could reduce fundus AF signal attributable to RPE at these locations.
Redistribution of adipose tissue towards an ectopic site can have dramatic effects on metabolic function.
Red meat intake was collected by each study.
Redox homeostasis governs a number of critical cellular processes.
Redox homeostasis is an important host factor determining the outcome of infectious disease.
Redox-mediated posttranslational modifications represent a molecular switch that controls major mechanisms of cell function.
Redox reactions have been established as major biological players in many cellular signaling pathways.
Redox reactions play a key role in maintaining essential biological processes.
Redox Signal.
Redox Signal.
Redox Signal.
Redox Signal.
Redox Signal.
Redox Signal.
Redox Signal.
Redox Signal.
Redox Signal.
Redox Signal.
Redox Signal.
Reduced ability to control motion of the whole-body center of mass ( COM ) has been shown to identify elderly people at risk of falling.
Reduced activation in key areas for successful navigation , as well as additional regions , was found alongside relatively normal task performance.
Reduced Activin signaling improves performance and protein homeostasis in muscles of aged flies.
Reduced activity in these brain regions was significantly associated with improved ( ie , faster ) flanker task performance at trial completion.
Reduced AS investment had the strongest association with depression and mediated the relationship between poor health or functioning and depression.
Reduced autophagy and accumulation of impaired mitochondria have been linked to progression of heart failure and aging.
Reduced autophagy has been associated with aging , leading to accumulation of dysfunctional or damaged proteins and organelles.
Reduced awareness has important implications for everyday function and decision-making.
Reduced brain-derived neurotrophic factor ( BDNF ) function has been suggested as a risk factor for late-life depression.
Reduced capacity to suppress CD4 and CD8 T-cell proliferation was observed for passage @number@ and @number@ bmMSCs and ucMSCs.
Reduced cerebrospinal fluid amyloid-β42 and increased retention of florbetapir positron emission tomography are biomarkers reflecting cortical amyloid load in Alzheimer's disease.
Reduced CMA activity contributes to protein accumulation in renal tubular hypertrophy , but may contribute to oxidative tissue damage in diabetes and aging.
Reduced CPS significantly underlies the link between CVD status and poorer EF.
Reduced CSPalpha expression occurred before synaptophysin levels drop , suggesting that it contributes to the initial stages of synaptic degeneration.
Reduced DNA repair capacity may play a role in amyotrophic lateral sclerosis ( ALS ) etiology.
Reduced EC adhesion molecule and chemokine expression inhibits the recruitment of tumor-promoting CCR2 ( + ) Tie2 ( - ) metastasis-associated macrophages.
Reduced EF and CPS are known to correlate with age-related frontal-lobe volume loss.
Reduced eIF5B expression may disrupt proteostasis and trigger cellular processes associated with stress responses.
Reduced erythrocyte deformability by H ( @number@ ) O ( @number@ ) was inversely related to the erythrocyte Gardos effect on the rheological function.
Reduced executive function and physical performance are common age-related conditions.
Reduced expression of DNA polymerase δ1 may be responsible for the decrease of DNA repair capacity in senescent cells.
Reduced expression of the receptor for this pathway has been reported to prolong the lifespan ; however , the underlying mechanisms are largely unknown.
Reduced expression was associated with wild-type BRCA status.
Reduced food intake , avoiding malnutrition , can ameliorate aging and aging-associated diseases in invertebrate model organisms , rodents , primates , and humans.
Reduced fractional anisotropy in the right uncinate fasciculus was found in carriers compared with controls.
Reduced glutathione is the most prevalent biological thiol and plays a crucial role in maintaining a reduced intracellular environment.
Reduced hip , ankle and trunk excursions along with reduced knee and ankle positive work were found in older runners.
Reduced HVa , decreased AD signature cortical thickness , and increased amyloid accumulation were significantly associated with increased odds of anosmia.
Reduced IGF signaling has been associated with increased lifespan and healthspan.
Reduced infection of keratinocytes after calcium-induced stratification confirmed the impact of junction formation.
Reduced inhibitory efficiency , which was poorer in older adults , predicted age-related decline in recall , over and above the effects of processing speed.
Reduced input of naive B lymphocytes is compensated by anergic , exhausted memory cells.
Reduced insulin / IGF signaling increases lifespan in many animals.
Reduced insulin secretion can result from reduced proliferative capacity and reduced islet function.
Reduced insulin secretion from the brain may subsequently reinforce longevity assurance through decreased systemic insulin / IGF signaling.
Reduced insulin sensitivity , mitochondrial dysfunction , and others are consequences of aging or secondary to physical inactivity.
Reduced internal LOC and increased external LOC have been found in cognitive disorders , but the neural substrates of these control perceptions are yet unknown.
Reduced Klotho levels may therefore increase cardiovascular risk in diabetes.
Reduced lean body mass may explain erlotinib pharmacokinetics and excessive acute toxicity in the elderly.
Reduced lean body mass over @number@ years ( median @number@ kg versus @number@ kg ) might account for these differences.
Reduced levels of these steroids have been linked to depression , anxiety and neurodegeneration.
Reduced mass and strength of both bone in osteoporosis and skeletal muscle in sarcopenia play a key role in the age-related incidence of fragility fractures.
Reduced mitochondrial DNA ( mtDNA ) gene expression and coding region variation have frequently been reported as being associated with the development of presbycusis.
Reduced muscle strength and visual and auditory deterioration can compromise clinical ability.
Reduced MYB expression , previously linked to development of an ET-like disease in model systems , associates with rs9376092 in normal myeloid cells.
Reduced myelination has been suggested as possibly having a role in the development of psychiatric disorders characterized by lack of social interaction.
Reduced NR3C2 expression following silencing did not significantly affect KLOTHO and CYP27B1 transcript levels in presence or absence of spironolactone.
Reduced overall caloric intake delays aging in various organisms.
Reduced pharyngeal peak pressure and increased UES relaxation pressure underscore the notion that tongue-hold swallows should not be performed when bolus is present.
Reduced phosphorylated tau ( p-tau ) in cerebrospinal fluid ( CSF ) has recently been proposed to provide such a biomarker in ALS.
Reduced physical activity levels and exercise intolerance increase muscle loss and decrease quality of life in both the aging and heart failure populations.
Reduced physical performance is an important feature of aging , and walking speed is a valid measure of physical performance and mobility in older adults.
Reduced physical performance predicted mortality in a dose-response manner and within all HIV disease strata.
Reduced quality of life and financial burden due to visual impairment and blindness begin to increase dramatically when individuals reach the age of @number@
Reduced rank regression was used to identify patterns of muscle mass , muscle strength , muscle quality , and fat mass related to physical function.
Reduced R bar was not associated with verbal memory.
Reduced regenerative capacity has been proposed as a mechanism.
Reduced regenerative capacity in tissues correlates with reduced stem cell function , which parallels a loss of microvascular density ( rarefraction ) and plasticity.
Reduced renal function increases NT-proBNP concentrations , and therefore it might be a confounding factor in chronic kidney disease ( CKD ) patients.
Reduced satiety sensing may have a role in the greater risk of obesity in middle age.
Reduced serum Klotho concentrations and decreased vascular Klotho gene expression were associated with the presence and severity of CAD independently of established cardiovascular risk factors.
Reduced serum testosterone is common among subfertile young men and aging men , and is associated with depression , metabolic syndrome and reduced sexual function.
Reduced shear stress and augmented oscillatory shear rate are associated with the proatherogenic phenotype observed with aging.
Reduced steroidogenesis in the knockout mice was associated with reduced antioxidant capacity , and increased expression of protein nitrotyrosine residues , a marker of ROS.
Reduced strength and function were found to be associated with a greater impact on physical performance than reduced muscle mass.
Reduced structural connectivity was found in the hippocampal connections to temporal , inferior parietal , posterior cingulate and frontal regions only in the Alzheimer's group.
Reduced winter-time dorsiflexor strength may predispose older people to increased risk of tripping-related falls , and warrants investigation in a multi-faceted falls prevention programme.
Reducing burden in caregivers might result in reductions of anger expression-in.
Reducing falls among seniors fosters the maintenance of their autonomy.
Reducing physical activities can lower positive affect , while the adverse effect may be balanced by increasing social activities.
Reducing senescent cell burden by genetic approaches or by administering senolytics delays or alleviates multiple age- and disease-related adverse phenotypes in preclinical models.
Reducing the number and length of stay ( LOS ) of these admissions has the potential to save NHS substantial costs while reducing iatrogenic risks.
Reducing the pain could improve overall patient satisfaction.
Reducing the rate of aging would have enormous medical and financial benefits.
Reducing these disparities will require a multi-faceted approach encompassing the social and environmental contexts of high-risk populations.
Reducing this difference between women and men is a real challenge for public health professionals and preventive medicine specialists.
Reducing vascular stiffness may reduce WMH progression and should be tested in randomized trials , in addition to testing antihypertensive therapy.
Reduction in active MMP9 occurred despite a nearly @number@.5-fold increase in free pro-MMP9.
Reduction in AK lesions was comparable to that reported with imiquimod @percent@ with fewer local AEs.
Reduction in angiogenesis was associated with downregulation of FAK and integrin αvβ3 in the co-cultures of glioma cells.
Reduction in hippocampal volume could represent a risk factor or a consequence of depression in older adults.
Reduction in melanogenically active melanocytes in the hair bulb of gray anagen hair follicles with resultant pigment loss is central to the pathogenesis of graying.
Reduction in mtDNA copy number disrupts mitochondrial membrane potential ( Δψm ) resulting in dysfunctional mitochondria.
Reduction in polypharmacy is a valuable target for weight management.
Reduction in the length of telomeres leads to the cessation of cell division and thus cellular senescence and apoptosis.
Reduction in the T-cell repertoire may contribute to decreased immune surveillance.
Reduction in vision is not inevitable but a manageable consequence of getting older.
Reduction in white matter connections was related to reduced functional connectivity , but we found no amyloid deposition in individuals with SCI.
Reductionist assumptions contributed to routinized , task-based approaches to care , resulting in what careworkers termed \ "assembly line care. \ "
Reduction of 18-MEA on weathered hair is accelerated with aging on elder hair.
Reduction of apoptotic cell death by these factors was confirmed in cultured CNS cells and in the ALS spinal cord.
Reduction of blood pressure by lifestyle measures and antihypertensive drug therapy reduces stroke in elderly men and women.
Reduction of cell proliferation was also observed with activation of AKT and mTOR-dependent cell survival pathways , which may also contribute to the tumor chemoprotection.
Reduction of COMT expression was readily detectable in cells exposed to picomolar level of E2 , comparable to other in vitro assays of similar sensitivity.
Reduction of CREB protein is partially based on pre- and posttranslational modifications as exhibited by an increase in the CREB-regulating microRNA 34b and CREB ubiquitination.
Reduction of functional difficulties did not account for improvements in depressive symptoms.
Reduction of hippocampal neurogenesis caused by aging and neurological disorders would impair neural circuits and result in memory loss.
Reduction of hPTEN was delayed in each of S. cerevisiae grx5Δ and ycp4Δ mutants.
Reduction of OTUD3 expression , concomitant with decreased PTEN abundance , correlates with human breast cancer progression.
Reduction of the activity of DNA repair machinery is a likely genetic cause.
Reduction of the muscular regulation capacity due to aging can be detected by performing sEMG during BFT by using a parameter in the muscles.
Reduction of Wasf1 gene expression dramatically reduced Aβ levels and restored memory deficits in a mouse model of AD.
Reductions in caloric intake have been shown to increase both the life- and health-span in a variety of animal models.
Reductions in cfPWV were correlated with increases in leg LM index ( r = @number@ P < @number@ ) .
Reductions in GSH then lead to increases in hydrogen peroxide , mitochondrial damage , and ultimately , cell death.
Reductions in inferior frontal regions correlated inversely with symptom severity , age , and Stroop interference scores in the BN group.
Reductions in pathogen and surrogate inocula were determined with excision sampling.
Reductions in pigmentation , rhytides , and elastosis were statistically significant ( P≤ @number@ ) .
Reductions in Reelin levels have been suggested to contribute to Alzheimer's disease ( AD ) pathophysiology.
Reductions in the 2f2-f1 DPOAE were found with both , high-level and low-level primaries.
Reduction with age of key enzymes of antioxidant protection superoxide dismutase and glutathione peroxidase in blood plasma and erythrocytes was determined.
Red wine showed the highest decrease on the fluorescence intensity.
Reed et al.
Reelin plays a pivotal role in neurodevelopment.
Reendothelialization was evaluated by staining with Evans blue after wire-induced carotid injury.
Re-engineered workflows were analyzed using the developed simulation tool.
Reengineering of electrode design could avoid reimplantation surgery in young children undergoing deep brain stimulation.
Re-epithelialization occurs from uninvolved skin and keratinocytes from follicles.
Re-establishing a favorable local mechanical environment may not only delay the requirement for an invasive joint reconstruction procedure but obviate the need entirely.
REE was measured by indirect calorimetry in fasting conditions and body composition by bioelectrical impedance.
Re-expression of AR reduced the activity of MMP-2 and MMP-9 in PC-3 cells.
Reexpression of cell-cycle related genes in differentiated neurons in AD might be rooted in aberrant mitogenic signaling.
Re-expression of PAX2 in PAX2-null human HGSC cells reduced cell survival via apoptosis.
Re-expression of SMP-30 was investigated in a biopsied adult liver ( n = @number@ ) that had been transplanted in a pediatric recipient.
Re-expression of survivin restores a competent spindle assembly checkpoint and reduces polyploidy.
Reexpression of the sensory-cell-specific miR-182 and miR-183 prevented outer segment loss.
Re-expression or an increase in SMP-30 was not observed in the liver of any pediatric recipient who had received an adult liver.
Reference data for the four metacarpal measures are presented.
Reference data were analysed and presented in age-groups , while the age-related change in RT was tested and characterized with linear regression models.
Reference deciles were created for the test results obtained from a sample of @number@ Italian subjects.
Reference instruments are valid but not easy to use for some joints.
Reference intervals are obtained from healthy individuals.
Reference intervals decreased with age for all enzymes , except GAA.
Reference intervals obtained from such individuals cannot be considered representative for seniors in a status of age-specific normal health.
Reference lists from retrieved articles were also reviewed.
Reference lists of eligible studies were also screened.
Reference lists of included articles and literature reviews identified during the search were reviewed.
Reference lists of included studies were scanned.
Reference lists of retrieved articles were hand-searched.
Reference lists of retrieved citations were hand searched for relevant studies.
References of included papers and reviews were checked.
Reference standard delirium diagnosis was based on Diagnostic and Statistical Manual of Mental Disorders ( DSM-IV-TR ) criteria , and was established by geriatricians.
References were included from 2001-2015.
Reference values of @number@ gait parameters are presented which researchers or clinicians can use for assessing and interpreting gait dysfunction in aging persons.
Reference values of PTH depend on vitamin D status of the reference population.
Referral to specialists for diagnosis before starting clinical treatment is useful to address these issues.
( Re ) fill adherence to oral hypoglycemics was measured as Proportion of Days Covered.
Reflectance confocal microscopy enhanced the diagnosis of pigmented facial macules with @percent@ sensitivity and @percent@ specificity.
Reflected wave timing differed modestly across age groups despite considerable differences in pulse wave velocity.
Reflecting the progressive aging of society , patients with swallowing disorders ( i.e. , dysphagia ) are increasing.
Reflecting the wider Cultural Turn , it has expanded the field of gerontology beyond all recognition.
Reflections on QOL as such.
Reflective considerations are presented to guide practice vis-à-vis the changing landscape surrounding options in dying.
Reflective journaling provides important insights into the process by which medical students draw upon mentored clinical experiences during their training.
Reflective memos were developed , and a cohesive interpretation of the raw data emerged.
Reflective writing techniques such as journaling help provide insights into the process by which medical students are mentored and develop into practicing physicians.
Reflex regulation of cardiovascular control during exercise by metaboreflex and baroreflex is altered by bed rest and spaceflight.
Reflex vasoconstriction is attenuated in aged skin due to a functional loss of adrenergic vasoconstriction.
Reflex vasodilation was attenuated in older adults ( P < @number@ ) .
Refractive errors were measured by cycloplegic autorefraction.
Refractive errors were measured by noncycloplegic subjective refraction.
Refractive state , age and ocular side demonstrated an independent , statistically significant impact on ∆PachyZ-PachyD and vector length PachyD.
Refraining from buying prescribed medications was measured with the question : ' Have you ever refrained from buying prescribed medication and care ? '
Refusal / underutilization of services is a major problem.
Regarding age differences , younger outperformed older participants in nearly all item positions.
Regarding anthropometric and computed tomography , prevalence rates were , respectively , @percent@ and @percent@.
Regardingautologous purpose , the possible loss of therapeutic function and cell properties during aging have been questioned in adults.
Regarding bilateral asymmetry , the right foot had a higher foot than the left foot.
Regarding climacteric symptoms , an improvement in the Kupperman index total score ( p = @number@ ) was observed.
Regarding cognition , long-term memory is the earliest form of memory to decline as is well recognised.
Regarding density of RGCs , tau P301L mice showed a similar age-related decline as in control mice.
Regarding fracture resistance , adhesive bonding or conventional cementation of zirconia FPDs showed no restrictions for posterior application.
Regarding global parameters , a weak inverse correlation was found between corneal staining and A ( r = @number@ P = @number@ ) .
Regarding global WM development , young adults had higher WM performance than children and older adults in both tasks.
Regarding HIV genes , there is evidence of an interaction between HPV and tat , rev , and vpr.
Regarding intra-hospital mortality , none of the predictive variables was associated with mortality.
Regarding its poor prognosis because of severe complications , there is an urgent need for properly established treatment guidelines and prophylaxis for patients at risk.
Regarding knowledge , the students obtained a mean of @number@ out of a scale from @number@ to @number@ points.
Regarding luting technique , the combination of mechanical and chemical pre-treatment appeared particularly crucial to obtain durable bonding to zirconia ceramics.
Regarding mycotoxins , there are currently no validated test methods that could be used in clinical diagnostics.
Regarding number of drugs taken , there is a significant negative effect on smell perception ( P < 0.001 ) .
Regarding pharmacologic treatments , antipsychotics have the strongest evidence base , although the risk to benefit ratio is a concern.
Regarding preparedness to teach a diverse classroom , @percent@ felt somewhat or very prepared to engage and motivate all students.
Regarding QoL , successful agers had significantly higher values than their unsuccessful aging counterparts ( p > @number@ ) .
Regarding reach , we compared participants ' baseline characteristics.
Regarding reaction time costs , children did not differ from adults in the recent-probes task and were less affected than adults in the n-back.
Regarding recommendations , we adopted the grading system introduced by the American College of Physicians.
Regarding satisfaction with body functioning , functional limitations were women's most important predictor of satisfaction , whereas for men body appearance was more important.
Regarding satisfaction with health , @percent@ were happy , even reporting having at least one chronic health problem ( @percent@ ) .
Regarding sex , there was no difference in mortality , so that males and females were regarded as a whole.
Regarding SSL , no improvement was found in either age group and at either consolidation intervals.
Regarding temperament , novelty seeking decreased and persistence increased slightly with age.
Regarding test protocol , a tensile test appeared more discriminative , particularly when combined with ' water storage ' aging.
Regarding the difference of sex roles in conventional Japanese society , working would be an effective solution especially for men to participate in social activities.
Regarding the domain of flow and timing , two studies were considered at high risk of bias.
Regarding the educational level of a patient , no effect was found.
Regarding the flexural biaxial testing , most of the resin cements were affected by polymerization mode and differences among groups were product dependent.
Regarding the kidney , clinical / pathological characteristics in CKD patients also coincide with those in the aging kidney.
Regarding the neutrophil elastase gene , the two medical devices with the higher concentration of HA displayed the greater effect.
Regarding the number of cases in this series , ES emerges as an important endemic area for PCM in Brazil.
Regarding the number of interventions , a correlation ( p-value = @number@ ) between age and number of interventions was observed for the book context.
Regarding the perception of the vertical , multisensory integration does not seem thus to depend only on right posterior cortical areas.
Regarding the relationships among elements , significant direct correlations were found among the Ca , P , S , and Mg contents in the LCFs.
Regarding the structure , differences were principally bacterial disposition in the surface and bacterial shape.
Regarding the subdimensions of health-related quality of life , favorable trends could be observed.
Regarding the translucency indices , transmission coefficient , translucency parameter , and contrast ratio have been used , and correlations among these indices were confirmed.
Regarding to aging , there is evidence that with DT performance during encoding the costs are substantial.
Regarding to the seniority subgroups in each kind of work schedule , the Body Mass Index was increasing with seniority in both schedules.
Regardless , Choto-san can be one of the choices for the treatment of vascular dementia as it is well tolerated.
Regardless , data from most Nordic countries remains limited , as does the information on specific causes of death.
Regardless of age , the most investigated determinants were those related with ' screen use ' and ' smoking'.
Regardless of cognitive status at baseline , > @number@ g / day DHA / EPA improved episodic memory ( P < .04 ) .
Regardless of comorbidities , renal artery stenosis is itself an important cause of cardiovascular morbidity and mortality.
Regardless of duration of SCI , all @number@ participated in dressing , bathing and leisure activities.
Regardless of foot position , challenges in stability were greater in elderly participants than young participants despite their similar movement time and shear forces.
Regardless of gender the lowering of the dehydroepiandrosterone sulfate content was observed in gerontic aged residents compared to middle aged.
Regardless of impairment level , activity is paramount to maintaining quality of life.
Regardless of instructions , older adults experienced higher relationship satisfaction , higher positive and lower negative affect than younger aged adults.
Regardless of not using real data , this work proves to be an asset , achieving a good performance in preventing alert situations.
Regardless of operation performed , the Timed Up and Go compared favorably to the more complex risk calculators at forecasting postoperative complications.
Regardless of pathophysiology and diagnostic criteria , the population of older adults with diabetes is highly heterogeneous.
Regardless of prior computer experience , subjects of all age groups were able to perform the tasks without instruction or feedback from an experimenter.
Regardless of sex , compared to control , all three exercise training approaches enhanced visuospatial function , but only multimodal training enhanced episodic memory.
Regardless of the age of the rememberer , participants ' early memories had the same episodic characteristics.
Regardless of the availability of a vaccine , new antiviral agents are necessary for treatment of VZV infections.
Regardless of the cognitive task , participants walked slower under dual-task conditions than under single-task conditions.
Regardless of the indications for surgery and the extent of planned liver resections , this population is more likely to suffer from relevant disorders.
Regardless of the machine , Intensity levels peaked between the 25-53 Hz and 46-82 Hz ( 2nd and 3rd wavelets ) bands.
Regardless of the method of induction , excess cohesion at telomeres in mitosis prevents a robust and efficient anaphase.
Regardless of the presence of RP , the rheological studies showed the pseudo plastic behavior of the systems.
Regardless of the strains , nearly all caregivers reported some benefits from providing care.
Regardless of the task , bimanual force initiation was slower than unimanual force initiation.
Regardless of whether clearing plaques is beneficial or harmful - which remains a subject of debate - it does not address the failing microglia population.
Regardless , the data reveal remarkable similarities in the ontogeny of sleep cycles in zebrafish and humans.
Regardless , urgent action is required by all stakeholders to address this issue.
Regenerated liver volumes were calculated and compared with clinicopathological factors , and correlations between liver regeneration and gene expression were calculated.
Regeneration of skeletal muscle depends on a population of adult stem cells ( satellite cells ) that remain quiescent throughout life.
Regeneration therapy using ADSC has received attention in the treatment of various dermatologic diseases.
Regenerative capacity is dictated by environmental and genetic factors that govern the balance between damage and repair.
Regenerative medicine deals with the possible use of stem cells to repair tissues damaged by aging and related diseases , including amyloidoses.
Regenerative potential of hCPCs is severely limited with age , requiring genetic modification to enhance therapeutic potential.
Regimen complexity was associated with medication nonadherence ( @date@ studies ) and higher rates of hospitalization ( @date@ studies ) .
Regina is a 38-year-old woman who has been trying to conceive for about a year.
Regional age-related change is accounted for by Cirrus SD-OCT in its normative database.
Regional CBF values were expressed quantitatively ( in ml / 100 g min ) and relative as a percentage of the wbCBF.
Regional cortical amyloid-β amyloid , as measured by 18F-florbetapir PET , may be a biomarker of specific cognitive deficits in non-demented Parkinson disease patients.
Regional deprivation was measured by the German Index of Multiple Deprivation.
Regional differences between university hospital districts were observed.
Regional effects of age on CBF differed from that of grey-matter atrophy.
Regional homogeneity ( ReHo ) rapidly maps regional brain activity across the whole brain.
Regional-hospital- and patient-level variability explained , respectively , @number@ @number@ and @number@ % of total score variance.
Regionally heterogeneous age effects were mainly located in several hubs ( e.g. , default network , dorsal attention regions ) .
Regionally , this was significant in the frontal , temporal , and parietal lobes.
Regional peculiarities in distribution of incidence of different variants of aging rates have been revealed.
Regional percentage SUR to that of anterior putamen was calculated.
Regional regression also revealed that both ChaCo ( β = @number@ ) and FDG-PET ( β = @number@ ) were significant predictors of PiB.
Regional spectral and complexity features are computed and used in a support vector machine model to discriminate between groups.
Regional statistical offices provided family addresses after approval by the ethical and data protection committees.
Regional susceptibility to neuronal damage induced by aging by exposure to neurotoxicants may be a reflection of highly variable regional energy requirements.
Regional sweating thresholds and RSR were attenuated in aged vs. young at all sites ( P < @number@ ) during whole body heating.
Regional-to-whole brain gray matter standardized FDG uptake value ratios were examined for associations with parental age across groups using automated regions-of-interest and statistical parametric mapping.
Regional variation in shape was then explored via a battery of multivariate statistical techniques.
Regional variations were assessed across the groups using one-way analysis of variance.
Regional volumes were normalized for total intracranial volume.
Region of interest analyses demonstrated a significant evaluative perspective by domain interaction within the adolescent sample only.
Regions in the high-scaling cluster included periventricular , caudal and rostral middle frontal , inferior and superior parietal , supramarginal , and precuneus white matter.
Regions of food residues were identified and removed from visceral fat using a machine learning method integrating intensity , texture , and spatial information.
Regions of interest included later myelinating frontal / temporal / parietal WM regions and control regions measured by fractional anisotropy ( FA ) .
Regions of interests were identified on Tract-Based Spatial Statistics images.
Regions of interest were defined in the left motor cortex , left putamen , and right cerebellar lobules V and VIII.
Regions of interest were identified in an activation analysis by presenting a block-design with dynamic fearful faces and dynamic landscapes to @number@ healthy individuals.
Regions of interest were placed on sites of normal marrow ( group A ) and degenerative changes ( group B ) on subtracted images.
Regions of neuroinflammatory disruption of the blood-brain barrier with increased permeability can be quantified and visualized with dynamic contrast-enhanced MRI.
Regions of the human brain develop at different rates across the first two decades of life , with some maturing before others.
Region-specific data on annual IHD mortality among adults aged @number@ to @number@ years and corresponding population statistics were collected.
Regions with reduced cortical thickness defined the seeds for the subsequent functional connectivity ( FC ) analyses.
Regions with significant CBF differences between T2DM participants and controls at baseline were detected using voxel-wise analysis.
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Registration ClinicalTrials.gov = NCT01172301.
Registration ClinicalTrials.gov = NCT01494909.
Registration date : 28 / @date@ .
Registration : NCT02417987 ( ClinicalTrials.gov identifier ) .
REGISTRATION NUMBER : ACTRN12611000813987.
Registration number clinicaltrials.com : KSMC-tempger-1.
Registration number : NCT00359424.
REGISTRATION NUMBER : NCT00497978.
REGISTRATION NUMBER : NCT00809328.
Registration : PREADViSE is registered at ClinicalTrials.gov : NCT00040378.
REGISTRATION : PROSPERO CRD42015010616.
Regorafenib did not appear to compromise health-related quality of life over the study duration and had a generally acceptable tolerability profile.
Regression analyses confirmed that age-related differences in episodic memory performance could be explained by individual differences in executive functioning.
Regression analyses demonstrated an inverse relation between BMI and serum folate but a positive relation for RBC folate ( P < @number@ ) .
Regression analyses did not show that risk factors for refeeding syndrome were associated with falls in electrolyte levels.
Regression analyses examined the association between Body Mass Index ( BMI ) and environmental infrastructure features , adjusting for demographics and lower body function.
Regression analyses examined the relationship between DTI indices and total MoCA score.
Regression analyses identify hypertension and pathological waist-circumference as factors independently associated to pathological edPW , and hypertriglyceridemia to pathological left-ventricle mass.
Regression analyses revealed that executive function uniquely predicted variance in source recall performance.
Regression analyses revealed that higher falls efficacy was more closely associated with better SRH than was having previously fallen.
Regression analyses revealed that TMS explains between 1-33% of total variance of the respective balance parameters.
Regression analyses showed that the difference between expectation and satisfaction of relatedness needs for spouse and children significantly predicted subjective well-being and depression.
Regression analyses showed that the level of hs-CRP was positively correlated with increasing age.
Regression analyses showed that WTP increased significantly with higher income , male gender , higher educational level , and privately insured status.
Regression analyses suggested that the CSF TauΔCasp6 levels combined with TauΔCasp6 brain pathology predict cognitive performance.
Regression analyses tested for statistical mediation of the association between income inequality and population health outcomes by country differences in trust and health expenditures.
Regression analyses were applied to examine associations of education with multimorbidity by region adjusted for age and sex distributions.
Regression analyses were conducted to examine factors associated with participation and change in participation.
Regression analyses were used to determine associations between vascular aging indices and qualitative performance measures.
Regression analyses were used to estimate associations between each anthropometric and performance-based measure at baseline and 10-year falls risk , incident fractures and mortality.
Regression analyses were used to examine institutional incentives as predictors of perceptions of benefits and costs of mentoring and time spent mentoring.
Regression analysis confirmed association of CAGn with depression.
Regression analysis demonstrated a significant reduction of the EVA in HD patients on a 5-year follow-up.
Regression analysis indicated change in BC could not be accounted for by calorie intake or physical activity.
Regression analysis is used to explain variance in tiredness by age.
Regression analysis is used to relate these outcomes to indicators of the demand for and supply of helpers.
Regression analysis measured the impact of premenstrual symptoms and sociodemographic factors on ADL.
Regression analysis results also showed that discrete psychobiosocial states accounted for a significant proportion of variance in motivational variables.
Regression analysis results indicated that the sensitivity gradually decreased by approximately @number@ dB every @number@ years ( p = @number@ ) .
Regression analysis results indicate that community engagement is closely associated with both neighborhood perceptions and well-being in this sample.
Regression analysis revealed that numeracy is related to performance across the lifespan.
Regression analysis showed that a higher nuclear color score correlated with lower MPOD ( t = @number@ P = @number@ ) .
Regression analysis showed that both age and visual acuity significantly contributed to the number of A and P goals.
Regression analysis showed that higher preoperative MPOD correlated with higher postoperative MPOD ( t = @number@ P = @number@ ) .
Regression analysis shows that age , education and social support are related to each component , and neuroticism and extraversion to two components of health.
Regression analysis was performed comparing diffusivities against age.
Regression analysis was performed to assess independent associations between TSFI and outcomes.
Regression analysis was used to ascertain the associations between sedentary behaviour patterns and frailty.
Regression analysis was used to determine if CVM grade can predict the amount of facial growth.
Regression analysis was used to examine the hypothesis.
Regression analysis was used to investigate the influence of these variables on total and item scores of ADL and IADL questionnaires.
Regression by future drinking patterns identified rCBF predictive of heavier drinking.
Regression line ( RL ) , slope and significance test for slope were determined for each parameter correlation with ageing.
Regression modeling was performed to identify which neuropsychological factors uniquely predicted current personality , controlling for age , gender , and premorbid personality.
Regression modeling was used to assess the relationship between postural angles and subgroups , and different BMI trajectory classes , adjusting for gender.
Regression modelling of MD in the significant regions demonstrated that an interaction model incorporating puberty , age and puberty×age best explained our findings.
Regression models adjusting for clinical risk factors were constructed to examine relationships between biomarkers and PFT outcomes.
Regression models have been widely studied to investigate the prediction power of neuroimaging measures as biomarkers for inferring cognitive outcomes in the Alzheimer's disease study.
Regression models included socioeconomic , dietary and anthropometric confounders from early life and adulthood.
Regression models relating SNPs to cerebrovascular neuropathology were adjusted for age at death , gender and cohort membership.
Regression models showed a significant relationship between a fluid intelligence measure and objective hearing aid benefit.
Regression models tested associations between personal well-being and perceived benefits of parkrun ( mental health and connection to community ) .
Regression models were adjusted for gray matter atrophy , age , gender , medication use , and obesity.
Regression models were constructed to assess the prospective associations between physical activity and function with mortality and new disease.
Regression models were constructed to test the association between clinical and demographic features and LRRK2 status ( outcome ) in @number@ newly recruited participants.
Regression models were supported with bootstrapping estimates.
Regression models were used to determine the effect of increasing VMS frequency on awakenings and WASO , as measured objectively and subjectively.
Regression models were used to determine the relationship between age and structural integrity of white matter tracts.
Regression models were used to evaluate age-related changes in REE in subjects stratified by sex and BMI.
Regression models were used to examine associations and t tests were used to look at racial differences.
Regression models were used to examine whether MCI was associated with a lower level of decision-making.
Regression models were used to relate PiB retention to cortical thickness and hippocampal volume.
Regression results indicate that depressive symptoms , cognitive status , and living alone were significantly associated with higher loneliness scores.
Regressions grouping and then separating women and men were compared.
Regressions of angle against age showed a cubic relationship.
Regressions with the Gallup-Healthways data statistically controlled several third-variables , yet none substantially altered the pattern.
Regression techniques are used to estimate the relationship between these VAS values and the original value set ( i.e. ' tariff' ) .
Regression techniques were used to evaluate the effect of demographics on cognitive performance.
Regression was used to determine the relationships between depressive symptoms , depression dimensions , and abuse variables.
Regrettably , dietary variety and quality are known to decline with advancing age.
Regucalcin had an inhibitory effect on rat brain microsomal Ca ( 2 + ) -ATPase activity.
Regucalcin is expressed in rat brain neurons and it is decreased in the cerebral cortex and hippocampus of the brain with aging.
Regucalcin is known to play a multifunctional role as a suppressor protein of cell signaling in many cell types.
Regular aerobic exercise has a positive effect on arterial function ( i.e. , arterial compliance ) .
Regular alcohol drinking was associated with decreased risk of peripheral artery disease ( OR : @number@ p = @number@ ) .
Regular and aerobic training may minimize aging changes of diastolic function.
Regular atrial tachycardia ( AT ) coexisting with AF occurred in @number@ ( @percent@ ) patients ; @percent@ initially presented with regular AT.
Regular care was defined as always , usually , or sometimes receiving care from family or friends because of SCD.
Regular dental care might moderate the risk of functional disability in elderly individuals with missing teeth.
Regular dizziness was ascertained during face-to-face medical interviews during 7- and 10-year follow-up.
Regular exercise and an active lifestyle during adulthood have been associated with reduced risk and protective effects for mild cognitive impairment and Alzheimer's disease.
Regular exercise and improvement of diet are important for the prevention of osteoporosis in the aging society.
Regular exercise has been confirmed as a pragmatic countermeasure to protect against cardiac injury.
Regular exercise has multi-system anti-aging effects.
Regular exercise improves the risk profile , but most people do not successfully change their exercise habits to beneficially reduce risk.
Regular exercise is promoted as a therapeutic strategy for age-associated endothelial dysfunction.
Regular exercise provides many physiologic benefits , reduces risk of disease outcomes , and triggers important psychological gains.
Regular exercise was associated with better odor detection thresholds , adding to the evidence that decline in olfactory function with age may be partly preventable.
Regular fitness assessments and targeted exercise interventions are warranted.
Regularly scheduled trips were less likely to be canceled.
Regular physical activity and exercise are important for healthy aging and are beneficial for chronic disease management.
Regular physical activity , and more particularly aerobic training ( AT ) , has demonstrated benefits on adults ' health.
Regular physical activity conveys health benefits , but the yield on physical function in the elderly , is less clear.
Regular physical activity is effective as prevention and treatment for different chronic conditions related to the ageing processes.
Regular physical activity is protective against , and beneficial for , mild cognitive impairment ( MCI ) , dementia , and Alzheimer's disease.
Regular physical activity reduces this risk by @percent@.
Regular protein synthesis is a needful and complex task for a healthy cell.
Regular routines for assessing weight loss and the potentially modifiable nutritional risk factors cannot be stressed enough.
Regular strength-balance exercises are highly recommended to reduce this problem and to improve health , well-being , and independence in old age.
Regular text-based screening sometimes excludes those with low literacy and those whose native language is different from the text.
Regular training programs are a concrete means to prevent and / or reduce functional decline due to aging.
Regular treatment with analgesics significantly reduced pain severity.
Regular users of GA BCCP continued to be screened within appropriate intervals once enrolled in Medicare due perhaps to educational and support components of BCCP.
Regular wound healing after an injury consists of a well-ordered sequence of overlapping phases of repair and essentially repeats the complex process of organ development.
Regulated cell death has essential functions in development and in adult tissue homeostasis.
Regulated cell death pathways have important functions in host defense and tissue homeostasis.
Regulated energy production and utilization are critical in maintaining energy homeostasis in normal cells and functional organs.
Regulated protein aggregation thus serves cytoprotective functions vital for the maintenance of cell integrity and survival even under adverse stress conditions and during aging.
Regulating guidelines of the local health insurance companies do not yet include this type of intervention.
Regulation of antioxidant and RONS balance , DNA base excision repair , and selective degradation of damaged mtDNA copies preserves normal mtDNA quantities.
Regulation of FGF signaling is complex in satellite cells , requiring Syndecan-4 , a heparan sulfate proteoglycan , as well as ß1-integrin and fibronectin.
Regulation of FoxO protein expression and activation was analyzed in cultured chondrocytes.
Regulation of intracellular ROS levels is critical since increases above normal concentrations lead to oxidative stress and DNA damage.
Regulation of matrix metalloproteinases ( MMPs ) is important for many physiological processes involving cancers , inflammation , tissue remodeling and skin aging.
Regulation of nucleotide excision repair is an attractive avenue to preventing or reversing these detrimental consequences of impaired nucleotide excision repair.
Regulation of the complex protein-folding environment within the organelle is essential for maintaining efficient metabolic output.
Regulation of these epigenetic mechanisms has been shown to have notable influences on the formation and progression of various neoplasms.
Regulation of Wnt signaling is crucial for embryonic development and adult homeostasis.
Regulative circuits controlling expression of genes involved in the same biological processes are frequently interconnected.
Regulators of immune-metabolic interactions include host genetics , nutritional status , and the intestinal microbiome.
Regulators of the tau pathway were impacted by the absence of tau , but no additional change was imparted by Pb exposure.
Regulatory and economic aspects are also discussed.
Regulatory hurdles of post-approval changes in the process may thwart companies ' efforts to implement new technologies.
Regulatory interactions between the dopaminergic and renin-angiotensin systems have recently been described in the substantia nigra and striatum.
Regulatory mechanisms of ALX / FPR2 , the lipoxin A4 receptor , expression have considerable relevance in inflammation resolution.
Regulatory mechanism was investigated using specific inhibitors ( mithramycin ) , mRNA silencing or decoy oligonucleotides , and expression vectors.
Regulatory T cells ( Treg ) are a sub-population of T cells that suppress self-reactivity and are implicated in immune tolerance towards malignant cells.
REGγ ( - / - ) mice display compromised VEGF-instigated neovascularization in cornea and aortic ring models.
Rehabilitation focused on improving underlying balance and gait deficits , as well as specific cognitive impairments , may significantly improve walking under dual-task conditions.
Rehabilitation of patients with knee OA should focus on increasing quadriceps muscle strength and endurance for both lower extremities.
Rehabilitation of stroke patients in this region should include interventions targeted at these domains and modifying the statistical determinants of HRQoL where possible.
Rehabilitation options have developed with advanced hearing aid technology.
Rehabilitation services after hospitalization , physical exercise , effective control on chronic illness , and social participation to reduce loneliness is recommended.
Rehabilitation unit was necessary in @percent@ of cases.
Rehospitalization rates were analyzed using Cochran-Mantel-Haenszel tests.
Rehospitalizations occurred for @percent@ of the patients and had more co-morbidities than others.
Reinfection occurs throughout life , with more severe disease occurring in older adults , immunocompromised patients , and those with underlying cardiopulmonary disease.
Reinforcement of the composite skin / sWAT can take place in different ways.
Reintroduction of miR-144 in CCA cell lines not only inhibited cell growth , but also significantly reduced cell migration and invasion capacities compared with controls.
Rejuvenation of senescent hCPCs will improve the outcome of regenerative therapy for a substantial patient population possessing functionally impaired stem cells.
Rejuvenation of the aging face , therefore , requires a multimodal approach to attain an overall natural and uniform result that is long lasting.
Rejuvenation of the aging hand has gained recent popularity.
Rejuvenation of the skin aims at reversing the signs of aging and can be established in the epidermis as well as in the dermis.
RelA / p65 and p50 are the most common NF-kB subunits and involved in the classical NF-kB pathway.
Relapses were associated with higher CSF NfH ( SMI35 ) values compared with stable disease.
Related empirical work has shown that , compared with younger adults , older adults attend to and remember positive information more than negative information.
Related factors included age , level of education , physical functioning , depressive symptoms , and undergoing health examinations.
Related FTD disorders include frontotemporal dementia with motor neuron disease , progressive supranuclear palsy syndrome , and corticobasal syndrome.
Relatedly , expression of the oxidative stress-related transcription factor Nrf2 was also increased.
Related neural underpinnings even in healthy aging are mostly unknown since no consistent administration for imaging is available.
Related old theories and suggestions are mentioned.
Related proteins or genes were detected with Western blot or real time PCR , respectively , in the cell lysates.
Related topics were databases and data integration.
Related websites and yearbooks were searched as well.
Related websites and yearbooks were searched as well.
Relating to the period effect , the most adequate scenario was selected from @number@ projection methods.
Relational complexity ( RC ) is a metric reflecting capacity limitation in relational processing.
Relational sociology frames the phenomenon of an ageing population in a dense network of social relations , primarily at the level of family and community.
Relation between serum AMH level and LH / FSH ratio was analyzed statistically.
Relation between the first cell cleavage time and embryo persistence in this stage ( cc2 ) was observed.
Relations between a person's age and at what age they think people enter later life were stronger for men than for women.
Relations between F & V intakes and bone mass at various sites were assessed by regression models.
Relations between regional brain volume change and age were determined using generalized additive models , an established nonparametric concept for approximating nonlinear relations.
Relationship between covariates and time to fall was examined using hazard ratios ( HRs ) derived from univariate and multivariate Cox proportional hazards models.
Relationship between the partners is a key determinant of sexuality in men.
Relationship between TPR and the ratio of the peak of SDPTG in young subjects was also analyzed.
Relationship-defining memories that were more vivid , positive , emotionally intense , and rehearsed related to higher marital satisfaction.
Relationship of spirituality with mental health status in elderly patients seemed bidirectional , that is , cause as well as effect relationship.
Relationship quality , happiness , satisfaction with vardenafil treatment , and safety and tolerability were assessed by physician interviews and patient and partner questionnaires.
Relationships among DC density , OSDI score , and corneal staining were analyzed.
Relationships among variables associated to sociodemographic , physical , cognitive , functional , and medical status were explored using a multiple correspondence analysis.
Relationships between adherence to the programme components and response were not clear-cut and need further attention.
Relationships between adults and parents are characterized by positive and negative qualities.
Relationships between age , gender , shape , location , side , and the cross-sectional area of the caudate tail were investigated.
Relationships between aging , adiposity , ART , and eicosanoids during HIV-infection require further study.
Relationships between APOA2 genotype and saturated fat intakes for anthropometric traits and plasma ghrelin were evaluated by analysis of variance.
Relationships between CAR and other variables were analyzed by correlation and regression analyses.
Relationships between Ca , Zn , Fe , Cu , Mg , and Hb levels were tested by Pearson's correlation analysis.
Relationships between CFL pattern and severity , age , gender , and subject-reported outcomes were explored.
Relationships between clinical ratings and regional cortical metabolic activity ( voxel-based ) were assessed using SPM2.
Relationships between donor characteristics and histologic properties were evaluated using mixed model analyses.
Relationships between FI and hormone levels ( as outcomes ) were explored using regression models.
Relationships between global cognition and FC were stronger among amyloid positive participants.
Relationships between health indicators and gender roles were explored.
Relationships between IGF-1 and FI were attenuated after adjusting for IGFBP-3.
Relationships between individual characteristics , frailty , self-management abilities and poor health were investigated with correlation analyses.
Relationships between measures of muscle fat / area with strength , function , KL and lesion scores were assessed using regression and correlational analyses.
Relationships between memory and FC remained regardless of amyloid level.
Relationships between other personality traits and the decline in MMSE score were not significant.
Relationships between parameters and age were assessed using Spearman's coefficients.
Relationships between sCysC concentration and indices of lung function were assessed by multiple regression analysis.
Relationships between sensorial alterations , aging , follow-up period , and adjuvant treatments should be further evaluated in prospective studies.
Relationships between the HGS with various sociodemographic and anthropometric correlates were examined using multiple linear regression analysis.
Relationships exist between the BPAQ-derived physical activity and bone density in healthy middle-aged and older men but not men with prostate cancer.
Relationships of human PFC exposure with puberty are not clear.
Relationships of PA and body composition changes were then assessed.
Relationships persisted after taking into account cortical thickness , amygdala volume , and resting perfusion.
Relationship status and gender had a slight effect on both of these relationship trajectories.
Relationship status was also significantly associated with mental health and satisfaction with life , but not physical health.
Relationship status was the most consistent predictor of women's evaluation of the experience.
Relationship stress can have a negative impact on people-patient and caregiver alike-behaviorally , psychosocially , and physiologically.
Relationships were assessed using parallel process latent growth curve models.
Relationships were further explored using natural eGFR splines.
Relationships were largely independent of initial BMI , self-reported caloric intake or dieting.
Relationships were similar after adjusting for health behaviors and chronic conditions , although the association between hospitalization and strength was attenuated.
Relationships with functional characteristics support the validity of gait variability features in elderly persons.
Relationships with network members differed according to the older adults ' sociodemographic and socioeconomic characteristics.
Relationship with age was assessed for each parameter.
Relations were analyzed primarily by Generalized Estimating Equation ( GEE ) models considering within-patient inter-eye relations.
Relations were not altered when stratified by age or body mass index.
Relations with cigar and pipe smoking , tobacco chewing , and snuff use were also null.
Relative accuracy of AHRS is mostly affected by the ability of all modules to locate the same global reference coordinate system at all time.
Relative accuracy was assessed by measuring the variation in relative orientation between modules during trials.
Relative accuracy was evaluated using the variation in relative orientation between modules during the trials.
Relative appendicular skeletal muscle index ( RASM ) and percentage skeletal muscle index ( SMI ) were obtained.
Relative beta power , however , increased while absolute / relative delta and theta power decreased massively.
Relative cerebral blood flow maps were calculated by using commercial software and standard parameters.
Relative changes in CL with age or weight were similar for FVIII and rFIX.
Relative changes in muscle parameters ( % ) were calculated.
Relative confidence accuracy was computed as the difference between confidence judgments for correct and incorrect responses.
Relative expansion of ECW was observed in older participants.
Relative frequencies ( RF ) were estimated for major histological subtypes and compared according to the years of diagnosis and birth.
Relative hypoglycemia risk was significantly ( P = @number@ ) higher in residents with moderate chronic hyperglycemia compared with those with tight control.
Relative intake of zeaxanthin to lutein decreased with age , with zeaxanthin to lutein ratios lower in females.
Relative leukocyte telomere length ( T / S ) was measured using quantitative real-time polymerase chain reaction assays.
Relative LTL was determined from peripheral blood DNA by qPCR.
Relatively few genetic alterations have been identified , likely owing to disease heterogeneity.
Relatively few researchers have investigated early antecedents of adult functional limitations in developing countries.
Relatively few studies have examined the effects of crystals on cartilage biomechanics or chondrocyte mechanotransduction.
Relatively high vocabulary scores of older adults are generally interpreted as evidence that older adults possess more of a common ability than younger adults.
Relatively large increases were observed for liver and thyroid cancer , while decreases occurred for cancers of the larynx and cervix uteri.
Relatively little is known about the factors that initiate such changes.
Relatively little research has been done to test the effectiveness of short-term research training programs.
Relatively low baseline complexity may , therefore , indicate control systems that are more vulnerable to cognitive and other stressors.
Relatively small increases ( > @number@ minutes per week ) in regular physical activity participation had significant and clinically meaningful effects on these outcomes.
Relatively to DLB group , correlation analysis between the cortical thickness and the Neuropsychiatric Inventory ( NPI ) hallucination item scores was also performed.
Relative number of nonagenarians ( 90 + ) was much higher among women as compared to men.
Relative OC-and FC-CBF increased significantly from 31±2 weeks postmentrual age to TEA.
Relative perfusion in the BGT measured at TEA was significant different compared to 52±1 weeks postmenstrual age.
Relative perfusion unit ( PU ) of the skin was detected by laser doppler flowmetry ( LDF ) .
Relative power values were calculated and compared among groups.
Relative predictive strengths of these measures were analyzed using Cox regression models.
Relative protein intake expressed as g / kg body weight was calculated and divided into quartiles for data analysis.
Relative regional CBF was highest in the BGT at all time-points.
Relative risk and numbers of colonoscopies needed for detecting one or more advanced neoplasm ( s ) were calculated for quintiles of the risk score.
Relative risk estimates for acute coronary events and for stroke events were somewhat lower than for cardiovascular mortality , but patterns were similar.
Relative risk factors of dry eye are gender , age , wearing contact lens , long-time using of eye solutions , taking anti-allergy drugs.
Relative risks of cardiovascular outcomes by three categories of reduced GFR were calculated by pooled random effects meta-analysis.
Relative risks ( RR ) and @percent@ confidence intervals ( @percent@ CI ) were estimated for each trial.
Relative risks ( RRs ) using a random effects model were calculated and sensitivity analyses were performed to assess the robustness of findings.
Relative risks were obtained from published sources.
Relative sensor kinematics accuracy ( i.e. joint ) varied between @number@.6° and @number@.6° over the same tasks.
Relative strategy complexity influences memory performance and aging effects on memory.
Relative survival of patients living in the most deprived district was compared to survival of patients living in all other districts by model-based period analysis.
Relative survival was significantly above @number@ for RP patients , except for high-risk patients.
Relative telomere length in genomic DNA was measured by real-time PCR.
Relative telomere length ( RTL ) in leukocytes was estimated by quantitative polymerase chain reaction assays.
Relative to age-matched healthy subjects , we found hyperactivation in these regions in CBD and hypoactivation in ABD.
Relative to Aβ- CNs , Aβ + CNs and Aβ + MCIs showed greater rates of cognitive decline , Aβ accumulation , and hippocampal atrophy.
Relative to baseline levels , the estimated change in eGFR for unit-increase in log-leptin was @percent@ ( @percent@ CI : @number@ - @number@ ) .
Relative to being with other people , time spent alone was associated with lower positive affect in the oldest-old.
Relative to children , adults correctly recognized more studied items and falsely recognized more critical lures.
Relative to controls , MCI subjects showed significantly greater proteolytic levels of the NR2B subunit.
Relative to HC , those with aMCI and naMCI were significantly impaired in focal PM accuracy ( p < .05 ) .
Relative to healthy controls , the PD patient group showed reduced functional connectivity in mesolimbic-striatal and corticostriatal loops.
Relative to lifeworld , there were differences between coming to terms with using a cane and coming to terms with using a walker.
Relative to mouse models , mouse disease signatures demonstrated consistent trends toward preserved mitochondrial function protein catabolism , DNA repair responses , and chromatin maintenance.
Relative to nondrinkers , alcohol consumption was associated with reduced odds of missing 6 + teeth.
Relative to the simulations carried out using the full CCA , models truncated at one CCA diameter strongly overestimated the amount of disturbed flow.
Relative to younger adults , all three associations were reduced in older adults.
Relative to younger adults , older adults exhibited reductions in WM capacity and in MPFC-DLPFC anticorrelations.
Relative to younger adults , older adults paid more attention to negative than to positive information when it related to morality traits.
Relative to younger persons , older individuals rated their health poorer with a greater rate of deteriorating health.
Relative values in each dose region ( interval of @number@ Gy ) were calculated on the basis of this normalization for each patient.
Relaxin's suppression of inflammation and fibrosis supports its potential as a therapy for cardiovascular and inflammation-related diseases , such as HF , AF and diabetes.
Released ATP produces paracrine effects on underlying tissues.
RELEVANCE TO CLINICAL PRACTICE : A well-functioning medicine assistance is crucial to enable older people to remain at home.
RELEVANCE TO CLINICAL PRACTICE : These data request for more emphasis on international guidelines in infection prevention initiatives.
RELEVANCE TO CLINICAL PRACTICE : To get public support for palliative care , the silence surrounding dying and death must be broken.
RELEVANCE TO PRACTICE : Palliative care and EOL decision-making will remain a nursing priority as people age and require increased care.
RELEVANCE TO PRACTICE : Quality care and the most productive use of resources are dependent on the public's engagement with health service providers.
Relevance to quality of life , need for nutrition and hydration , and ethical considerations in the decision process are discussed.
Relevant articles were analyzed.
Relevant assents are obtained at baseline to enable future involvement in a range of potential trials.
RELEVANT CHANGES : Six problems were selected as priorities , however after the policy dialogue , only five were agreed as priorities by the stakeholders.
Relevant clinical studies have been few and have used inconsistent results and methodology ( types of compounds , combinations , and supplementation time ) .
Relevant experimental models may be informative.
Relevant extrinsic risk factors are home hazards , wrong use of assistive devices and bad footwear.
Relevant factors impeding surgical treatment include the significantly decreased bone stock and the incapability of the patients to partially weight bear following surgery.
Relevant information on the demographics and status of H. pylori infection was retrieved from the electronic database.
Relevant information relating to cardiovascular risk factors was also collected.
Relevant information , such as study population characteristics , autoantibodies studied , analytical methods and diagnostic performance characteristics was independently extracted by two reviewers.
Relevant issues are illustrated with examples of unsuccessful and successful trials , with a major emphasis on clinical trials of physical activity in older persons.
Relevant journals were hand-searched and reference lists from retrieved studies were reviewed.
Relevant papers ' reference lists were also reviewed for thoroughness.
Relevant publications were selected and summarized qualitatively.
Relevant references from retrieved articles were also evaluated.
Relevant studies were identified by a systematic search of MEDLINE , Embase and Web of Knowledge databases.
Relevant websites and reference lists of included trials were checked.
Reliabilities of Big Five scales were comparable to the HRS and MIDUS , even though NSHAP's battery is shorter.
Reliabilities of the changes in composite scores were low , but averages of the three changes had larger , albeit still quite modest , reliabilities.
Reliability and validity analyses comparing observer ratings for each group activity on the individual-level measures of attendance and engagement showed good psychometric properties.
Reliability and validity indexes showed that our items display similar psycholinguistic characteristics to those of other corpora.
Reliability and validity indicators for the standards ranged between @number@ and @number@
Reliability and validity of the Male OPAQ™ were assessed using Pearson's r.
Reliability coefficients of the scale measured with the internal consistency method and test-retest were ≥ @number@
Reliability , however , proved to be poor owing to heterogeneity of the sample.
Reliability indexes were over requested standards.
Reliability ( internal consistency and test-retest ) , validity ( concurrent and know groups ) , and responsiveness were assessed.
Reliability ( internal consistency ) was assessed by Cronbach's alpha coefficient.
Reliability of each factor varied , and was strongest for the positive emotional domain for caregiver burden.
Reliability of root fractions was assessed using @number@ duplicate readings and calculated using Kappa.
Reliability of sleep spindle scoring can be improved by using qualitative confidence scores , rather than a dichotomous yes / no scoring system.
Reliability was assessed by measuring correlations between repeated measurements @number@ week apart.
Reliability was excellent at the middle area and fair to good at both ends.
Reliability was found to be very good as well , independently of the use of whole or half digits.
Reliability was good to excellent when whole weeks were assessed.
Reliable age-related residual variance implicated additional factors particularly in children's developing multi-tasking performances.
Reliable and valid tools are available for health care providers to screen older adults for fall risk.
Reliable data for the future demand are presently not available.
Reliable data on various indicators of health of older adults in Eastern Europe are lacking.
Reliable diagnosis of PAD is critical for appropriate conservative management of IC patients with LSCS in an Orthopedic Surgery Outpatient Department ( OSOPD ) .
Reliable estimates of prognosis would help to inform care and management of this frail and vulnerable population.
Reliable individual differences were found in all @number@ learning parameters.
Reliable information on health status of ageing people with an intellectual disability will become available in the next few years based on current Dutch research.
Reliable methodology for predicting the age of mature dogs is currently unavailable.
Reliable prediction of the aging process is important for assessing the risks of aging-associated diseases.
Reliable tracking of memory requires assessment instruments that are stable over time to better understand changes potentially attributable to neurodegenerative disease.
Reliable , valid measures and tools are a prerequisite for studying organizational context and research utilization.
Reliance on sources of support varied with participants ' sociodemographic factors as well as healthcare and medication use.
Relief of symptoms was achieved in @number@.5-100% of cases.
Relieving symptoms and paying attention to personality factors that modify LS seem to be key-factors in the care of elderly.
Religious beliefs are founded both on propositional statements for doctrine , but also on episodic memory and imagery.
Religious factors assessed included life-changing religious experiences , spiritual practices , and religious group membership.
Religious fasting also suggested having similar benefit ; however , such studies are still scarce.
Religious feelings may parallel the symptoms of anhedonia or a dysphoric mood and could represent the experience of an existential void.
Remaining at-risk drinkers reported that medical evidence that alcohol was harming them would motivate them to reduce drinking.
Remaining record abstracts were reviewed to identify studies for full text retrieval.
Remain unclear issues in the application of drugs melatonin at various complications of pregnancy and gynecological diseases.
Remarkable phenotypic heterogeneity was observed in them.
Remarkably , anti-gSG6 IgG levels among responders were high in children and gradually declined with age.
Remarkably both can generate all somatic cell types in organisms.
Remarkably both populations are sustained with passages suggesting that transformed cells eventually enter a senescent state.
Remarkably , centenarian studies revealed WRN and LMNA polymorphic variants among those who have escaped various geriatric disorders.
Remarkably , duration of treatment was correlated with time to pregnancy ( r = @number@ P = @number@ ) .
Remarkably , education , wealth , and income are health-protecting but have very little impact on two-year mortality rates conditional on health.
Remarkably , efficient regeneration continues to occur following repeated injuries.
Remarkably , expression of dAven in Xenopus egg extracts resulted in G2 / M arrest that was comparable to that caused by human Aven.
Remarkably , however , the rate of progression of DTBZ binding loss was significantly slower in younger patients ( p < @number@ ) .
Remarkably , inactivation of SIRT7 can reverse the transformed phenotype of cancer cells and reduce their tumorigenicity in vivo.
Remarkably , in both young and old animals a lack of exercise reduced the scale invariance in activity fluctuations to the same level.
Remarkably , incubation with @number@ µM Lycogen™ for @number@ h ameliorated UVA-induced cell death and restored UVA-induced downregulation of procollagen in a dose-related manner.
Remarkably , KI mice homozygous for either mutation recapitulate the phenotypes of Psen1 ( - / - ) mice.
Remarkably little has been written on the biology of essential tremor ( ET ) , despite its high prevalence.
Remarkably , LRRK2 silencing experiments significantly reduced basal COX-2 levels and COX-2 induction after a pro-inflammatory stimulus.
Remarkably , miR-143 failed to induce growth arrest in BJ-hTERT cells.
Remarkably , mouse models frequently upregulated stress response genes that were consistently downregulated in human diseases.
Remarkably , NAP1L1 suppresses both these interactions.
Remarkably , newly identified psychosocial problems were not followed by any consequences.
Remarkably , @percent@ of the known genes from those @number@ most significant genes are associated with either inflammation or immune system activation.
Remarkably , progerin expression and senescence phenotypes are lost in iPSCs but not in differentiated progeny.
Remarkably , progerin is also present in normal cells and appears to progressively accumulate during aging of non-HGPS cells.
Remarkably , psychosocial function improves with age , with diminished psychotic symptoms , reduced psychiatric relapses requiring hospitalization and better self-management.
Remarkably , SIRT6-deficient mice exhibit lower levels of chromatin-associated SNF2H in specific tissues , a phenotype accompanied by DNA damage.
Remarkably , some special species , i.e. , Methanobacterium , Butyricimonas , Deinococcus , and Streptococcaceae , have been found in Gaotian villagers.
Remarkably , the ERiQ profile was shared with the majority of in-vivo aged tissues.
Remarkably , the human prostate epithelium also secretes exosomes , which fuse to sperm in vitro to modulate their activity.
Remarkably , the loss of proliferative capacity and stemness of hMSCs can be counteracted through proteasome activation.
Remarkably , there have only been a handful of such studies using organisms with high regenerative capacity.
Remarkably , these age-related changes are not distributed uniformly across the genome.
Remarkably , these data also fit the mTOR-centered model of aging.
Remarkably , these effects were produced by an ampakine , CX929 , with a short half-life.
Remarkably , these events progressed over a 3-week period of time after weaning.
Remarkably , we observed that the identified cell cycle specific common network played an important role in replicative senescence as a key regulator.
Remelted HXLPE compression cylinders ( n = @number@ per test condition ) were subjected to fatigue experiments and similar oxidation characterization.
Remember-cued naturally cycling women recalled more list @number@ items than oral contraceptive users , young men , and postmenopausal women.
Remembering complex events requires binding features within unified objects ( conjunctions ) and holding associations between objects ( relations ) .
Remembering object positions across different views is a fundamental competence for acting and moving appropriately in a large-scale space.
Remembering the past and envisioning the future rely on episodic memory which enables mental time travel.
Remission in elderly patients has been little studied.
Remission ( MADRS score ≤9 at discharge ) was experienced in @number@ ( @number@ % ) of the patients.
Remission of type @number@ diabetes was @number@ and @percent@ in T2DMhigh and T2DMlow , respectively.
Remitted MDD was related to smaller entorhinal cortex volumes ( p < @number@ ) .
Remitting seronegative symmetrical synovitis with pitting oedema ( RS3PE ) syndrome mainly affects elderly men and responds well to steroids.
Remodeling in hypertension can be either eutrophic or hypertrophic.
Remotely transmitted data were processed in order to obtain AF incidence and time of PA in the form of collective time series daily sampled.
Removable-denture wearers also had lower self-perceived nutritional status and BMI compared to fixed-denture wearers.
Removal of SnCs delays several pathologies and increases healthy lifespan.
Removed from a lesbian community context , intergenerational continuity vanishes and the old lesbian emerges as the cultural other.
Removing error-adjacent responses reduced variability as measured by the coefficient of variation , but did so similarly for younger and older adults.
Removing or replacing interword spaces slowed reading times and impaired normal eye movement behavior for both age groups.
Removing specific components from the PNNS-GS did not modify the findings.
REM sleep behavior disorder also contributed reduction of NRC although it did more mildly than visual hallucination.
Renal biopsies from @number@ patients showed TBMN and focal segmental glomerulosclerosis ( FSGS ) .
Renal biopsy continues to play an essential role in the clinical assessment of hematuria , proteinuria and kidney failure.
Renal biopsy , performed the older sister , revealed cystic focal segmental glomerulosclerosis , arteriosclerosis , tubulointerstitial fibrosis , and tubular atrophy.
Renal disorders ( @percent@ ) represented the most common adverse drug reactions and the most frequently implicated drug classes were diuretics ( @percent@ ) .
Renal dysfunction , arrhythmia , preoperative inotropes , and emergency surgery were the predictors for mortality common to all groups.
Renal dysfunction in HF has been attributed , among others , to biochemical , hormonal , and hemodynamic factors , coupled with pharmacological interventions.
Renal dysfunction ( RD ) is a frequent comorbid condition and a major determinant of outcomes in patients with heart failure ( HF ) .
Renal fibrosis contributes to declining renal function in the elderly.
Renal fibrosis was comparable in WT , TREM1 / 3 double KO and DAP12 KO mice.
Renal function and homocysteine were also associated with cortical atrophy but not with the cognitive variables.
Renal function and urological disorders are a concern in these patients , and issues related to sexuality are an important but often-overlooked issue.
Renal function at @number@ @number@ @number@ and @number@ days was assessed.
Renal function ( estimated glomerular filtration rate , eGFR ) was assessed with the Chronic Kidney Disease epidemiology collaboration ( CKD-EPI ) formula.
Renal function recovery was defined as a return to the baseline serum creatinine ( SCr ) levels.
Renal function should be considered when interpreting NT-proBNP levels in older adult patients admitted for dyspnoea.
Renal function was evaluated by serum creatinine , urea , and estimated glomerular filtration rate ( eGFR ) , calculated using the MDRD-4 formula.
Renal histopathology was evaluated after @number@ months of stable hyperglycemia.
Renal impairment decreased significantly within all of the groups ( p < 0.01 ) .
Renal impairment during LAM-ADV therapy improved on shifting to TDF ; only in @number@ cases was a second shift to entecavir needed.
Renal impairment was characterized by low-grade albuminuria.
Renal involvement , either isolated or in the context of systemic vasculitis , is common.
Renal involvement in Cockayne syndrome is rare and its pathogenesis is yet unknown.
Renal issues are among the most commonly encountered complications in the intensive care unit , increasing mortality , morbidity , and health care costs.
Renal , neurological , and access-site complications were all greater in the very elderly cohort.
Renal senescence , as well as physical and mental decline , increase this susceptibility.
Renal tissue samples obtained at autopsy from a male baby ( @number@ months old ) with no renal disease were also examined.
Renal transplant recipients are at increased risk of reactivating latent tuberculosis infection ( LTBI ) and progressing to active tuberculosis ( TB ) .
Renal vasodilating capacity , endothelium-dependent vasodilation in the brachial artery , carotid-femoral pulse wave velocity and carotid stiffness were measured.
Renin-angiotensin system inhibitors have a better tolerability profile than diuretics.
Renin- angiotensin system , which causes high blood pressure , is found to be involved in bone metabolism.
Re-optimizing the filtering frequencies , we were able to reduce this difference to ~400 ms.
Reorganization and team development can improve quality and performance but projects in primary care frequently do not attain the targeted results.
Repair failure or error-prone repair leads to mutations which potentially could be rescued by allotopic expression of proteins.
Repair is organized with the other DNA metabolism pathways in the organelle membrane-associated nucleoids.
Repair of damaged DNA is critical for maintenance of genetic information.
Repair of DNA double-strand breaks via homologous recombination can produce double Holliday junctions ( dHJs ) that require enzymatic separation.
Repair was elective in @number@ and emergent in @number@ patients.
REP cells are widely distributed in the renal cortex and outer medulla.
Repeatability across two magnetic resonance examinations ( n = @number@ ) and accuracy against intravascular pressure measurements ( n = @number@ ) were assessed.
Repeatability and reproducibility were examined by calculating intraday and interday coefficients of variation ( CVs ) .
Repeatability , construct validity , and responsiveness of the new interval scale were examined.
Repeatability of most items was acceptable.
Repeatability was significantly higher when the observers used half digits compared to whole digits.
Repeated alcohol intake measurements were used to categorize participants into alcohol consumer types , accounting for longitudinal variability in consumption.
Repeated bouts of transient reactive oxygen species production as seen with regular exercise may be needed to increase resistance to oxidative stress in older individuals.
Repeated cell divisions and aging impair stem cell function.
Repeated cell divisions induce DNA damage accumulation , which impairs stem cell function during aging.
Repeated intravenous cell doses during disease progression may be the best approach for cell-based ALS treatment.
Repeated measure ANOVA was used to compare the changes of APA among the six blocks.
Repeated measurements of @number@ pairs of randomly selected models were taken to check the reliability of our results.
Repeated measurements were conducted on @number@ subjects to estimate intra- and inter-rater reliability.
Repeated-measures analyses adjusted for age , sex , education , comorbidities , and family history of dementia were conducted.
Repeated measures analyses identified factors associated with improved FISI scores among women with baseline scores > 0.
Repeated measures analysis of covariance was used.
Repeated-measures analysis of variance evaluated differences in cognitive status , falls , and functional measures between groups at annual reassessment.
Repeated-measures analysis of variance verified a significant time by group interaction ( P = 0.038 ) .
Repeated measures and multivariate ANOVA were used to compare mean CV% and bone outcomes between the methods within and between the groups.
Repeated measures ANOVAs and Bonferroni post hoc tests determined the effects of time and group on each muscle outcome.
Repeated-measures ANOVA was used , with α set at @number@
Repeated measures ANOVA were used to assess changes in hemoglobin concentrations , and changes in both heart rate and performance outcomes.
Repeated-measures ANOVA , Wilcoxon signed-rank tests , and Mann-Whitney U-tests were conducted for statistical analysis.
Repeated measures generalized linear models were conducted.
Repeated measures in children show a systematic decrease in %BF for any given BMI from age @number@ to @number@ to @number@ years.
Repeated measures latent class analysis of longitudinal data from @number@ Norwegian individuals indicated three main pathways to adulthood among women and men.
Repeated measures linear mixed-effects models showed that age was the most robust time-related predictor of declining SQoL.
Repeated-measures logistic regression was used to determine if the rates of internalizing and externalizing problem behaviors varied by group and sex.
Repeated pharmacological stimulation of NK3-R in aged rats was found to improve learning in the water maze and in object-place recognition.
Repeated serum glucose measurements were used as the outcome variables.
Repeated statements feel easier to process , and thus more truthful , than new ones ( i.e. , illusory truth ) .
Repeated total daily activity measures ( leisure and non-leisure physical activity ) were derived from actigraphic recordings for up to @number@ days.
Repeated treatments were performed every two weeks for a total of three times , over a total of @number@ weeks ' observation.
Repeated UV-A1 exposures did not suppress type I procollagen expression.
Repeat element hypomethylation was rare in MDS but marked the transition to AML in some cases.
Repeating a BMD measure within @number@ years to improve fracture risk stratification may not be necessary in adults this age untreated for osteoporosis.
Repeat measures were taken from @number@ participants for each accommodative demand at a second visit.
Reperfusion , but not the interactions between the prediction scores and reperfusion , were predictors of outcome ( P > 0·5 ) .
Repertoire properties can now be studied at large-scale through next-generation sequencing of rearranged Ig genes.
Repetition enhanced the parietal effect in all but older adults.
Repetitive seizures can increase Aβ-peptide production and cause neurotransmission dysfunction and cytoskeletal abnormalities or a combination of these.
Repetitive stimulation studies for neuromuscular junction disease are greatly affected by decreasing the limb temperature.
Repetitive transcranial magnetic stimulation ( rTMS ) has been introduced as a new and effective treatment option for major depression.
Replacement of dysfunctional mitochondria with functional exogenous mitochondria is proposed as a general principle to treat these diseases.
Replacement of human sera with antibodies targeting abundant neuronal surface proteins resulted in a comparable enhancement of Aβ ( @number@ ) accumulation in mouse neurons.
Replacement with non-vaccine serotypes constituted approximately @percent@ of the cases.
Replenishing or rejuvenating the aged / dysfunctional vascular cells is critical to the effective repair of the vasculature.
Replenishing qi and strengthening Shen is a widely used method that carries out ' treating different diseases by the same method'.
Replica analysis showed significant wrinkle reduction in the fibroblast group and the ADSC group.
Replicable expression quantitative trait locus functionality was identified for @number@ loci in the adult human brain.
Replicas of @number@ selected subjects per group were assessed for marginal quality under a SEM at 200×.
Replicated CNVs were further investigated for association with healthy aging and aging-related diseases , while association with longevity was additionally tested in Caenorhabditis elegans.
Replicate studies performed on a subset of @number@ of the original CSF samples verified @number@ high confidence miRNAs.
Replicate weights were applied to account for the survey's complex sampling methods.
Replicating prior findings , negative item effects in regions of the default mode network in young subjects were reversed in older subjects.
Replication analyses conducted in cohorts with single-visit BP data showed positive replication of associations and a nominal association ( p < @number@ ) .
Replication and further research is essential for clarifying the sleep duration-cognition relationship in youth and adults of all ages.
Replication and the development of normative data are required for clinical translation.
Replication confirmed the involvement of HLA , LRRK2 , MAPT , TRIM10 , and SETD1A in PD.
Replication fork collisions with ICLs can be visualized and different encounter patterns identified and quantitated.
Replication in a larger cohort is needed to support these findings.
Replication in one cohort identified a set of @number@ SNPs associated with episodic memory ( P ≤ @number@ ) .
Replication of our top results was performed in the Heredity and Phenotype Intervention ( HAPI ) Heart Study ( n = @number@ ) .
Replication of such results in well controlled studies is essential to clarify the effects of marijuana.
Replication of their results is required , as is further research to explain the association between renal function and GCC thickness.
Replication of the strongest genetic associations is performed in two independent datasets from the Children's Oncology Group and the California Childhood Leukemia Study.
Replication studies are needed to confirm our data.
Replication was performed using data from the CHARGE / SpiroMeta consortia.
Replication was sought in 1311-21860 subjects from @number@ independent cohorts.
Replication was sought in a case-control study of ischemic stroke.
Replication was sought in two additional cohorts ( N = 670 and @number@ ) .
Replicative senescence occurs in response to telomeric DNA erosion , and telomerase expression can offset replicative senescence leading to immortalization of many human cells.
Replicative senescence ( replicative CS ) has been described for all metabolically active cells that undergo a spontaneous decline in growth rate.
Repopulation was quantified by flow cytometry and histochemical estimation of dipeptidyl-peptidase IV enzyme activity of donor cells in the negative host liver.
Reported active ( P = 0.02 ) and passive ( P = 0.01 ) oral sex was associated with an absence of sexual dysfunction.
Reported arm movement time ( MT ) of all participants increased with target distance.
Reported data on endocrine changes in different ND have often been non-conclusive or conflicting.
Reported dropout rates were low and compliance rates high.
Reported estimated 5-year overall survival was @percent@ , with significant association with tumor stage , hormone receptor and HER2 status.
Reported findings from @number@ of the @number@ intervention studies investigating the effect of multicomponent strategies on fluid intake or dehydration described a positive effect.
Reported levels of enjoyment following game play increased during the study.
Reportedly , nonsteroidal anti-inflammatory drugs ( NSAIDs ) mitigate DAergic neurotoxicity in rodent models of PD.
Reported nutrient intake and food selection were compared with age-specific Recommended Dietary Allowance and USDA Pyramid Food Guide.
Reported PID was statistically significant for p < @number@
Reported reasons for concealment largely reflected concern for others.
Reported response interactions included attenuated response , no response , and good response , whereas a subset showed increased progression of AMD.
Reported senolytics include dasatinib , quercetin , navitoclax ( ABT263 ) , and piperlongumine.
Reporter analysis revealed that CircPVT1 decreased the cellular pool of available let-7 , and antagonizing endogenous let-7 triggered cell proliferation.
Reporter assay revealed that transcriptional activation of the CLDN8 promoter by androgen is dependent on these androgen-responsive elements.
Reporting : according to CONSORT @number@
Reporting being taught on elder abuse was inversely associated with a good performance in detecting neglect.
Reporting of HS-Aging pathology increased dramatically among ADCs in recent years , to nearly @percent@ of autopsies in @number@
Reporting positive and negative treatment outcomes is important to improve our knowledge regarding these reactions.
Reporting SA was low in visits with a diagnosis of dementia and classified as a preoperative visits.
Reports are scanty regarding whether yoga can improve age-related degenerative changes in healthy active men.
Reports detailing adverse event falls were tabulated.
Reports exhibiting maternal inheritance of telomere length in Down syndrome child are very scanty.
Reports indicate that food fortification in the region is sporadic and ineffective , and the use of dietary supplements is low.
Reports of age-related changes to medial prefrontal cortex ( mPFC ) activity during socio-cognitive tasks have shown both age-equivalence and under recruitment.
Reports of cases with minimally invasive treatment are sparse , and no standardized treatment protocol has been established.
Reports of @number@ intervention studies met inclusion criteria from the list of @number@ generated through the database searches.
Reports of orthopaedic surgeon shortages raise concerns about the ability of the health-care system to meet current and future demand in orthopaedics.
Reports on age-related changes of ( HPA ) axis activity are equivocal.
Reports related to aging could also be collected as well as social questions which motivated caregivers to search for this kind of job.
Reports were then processed by SQLServer and NegEx.
Representation of reward value involves a distributed network including cortical and subcortical structures.
Representations of the sexuality of older people have been largely absent in mainstream films until recent times.
Representative cases from patients in their 30s , 40s , and 50s are presented.
Representative changes of age-related changes are presbyopia , cataracts , and presbyacusis.
Representative children were selected by probability proportional to size sampling methods to assess compliance of YYB and the intervention efficacy.
Representative ECM proteins , collagen type I and matrix metalloproteinase-1 , are significantly up-regulated by treatment of ATSC-Ex.
Representative examples included the new roles of osteocytes in bone homeostasis and endocrine functions.
Representativeness of the sample was obtained by using weighted data.
Representative regions-of-interest ( ROIs ) were determined automatically in gray matter ( GM ) and white matter ( WM ) on T1-weighted scans.
Representing only @percent@ of its dry weight , these compounds represented together about @percent@ of the total antioxidant activity of the extract.
Repression of Parp1 in mouse ESCs decreases expression of pluripotent markers and induces differentiation.
Repression of RUNX1 is important for the growth promotion ability of EZH2 in AR-independent cells.
Reproducibility of MRS was evaluated with coefficient of variation , standard errors of measurement , and intraclass correlation coefficients.
Reproducibility was investigated by calculation of scatter values and statistical significance between overlapping groups was assessed by the calculation of intra-model distances , q.
Reproducible CWT on palpation was the initial step and was recorded before further examinations were initiated.
Reproductive ageing in women is characterized by a decline in both the quantity and quality of oocytes.
Reproductive aging coincides with endocrine changes that are not solely reproductive in nature and culminates in hypergonadotropic hypogonadism and amenorrhea.
Reproductive aging in females is associated with a loss of ovarian function characterised by a reduction in the number and quality of oocytes.
Reproductive cessation is perhaps the earliest aging phenotype that humans experience.
Reproductive function , semen quality , hormonal parameters , prostate-related pathologies , and PSA levels were measured.
Reproductive hormones have long been thought to have a significant impact on brain function in humans.
Reproductive hormones reflect the activity of follicle pools and provide information about ovarian aging.
Reproductive senescence occurs later in baboon females than males.
Reproductive senescence , such as menopause , is also dependent on multiple intrinsic genetic factors.
Reproductive success increased up to age @number@ and was relatively stable until a decline from age @number@
Reprogramming cell fates towards pluripotent stem cells and other cell types has revolutionized our understanding of cellular plasticity.
Reprogramming of gene expression contributes to structural and functional adaptation of muscle tissue in response to altered use.
Reprogramming of gene expression is fundamental for skeletal muscle adaptations in response to endurance exercise.
Repurposing ARBs for the treatment of brain disorders , currently without effective therapy , may be of immediate and major translational value.
Requests for data and biomaterials can be submitted to the LifeLines Research Office [ LLscience@umcg.nl ] .
Requiring adult participants to complete a secondary task while evaluating informants ' credibility impaired their ability to make use of calibration information.
Requiring written information to include numeric AE-likelihood information might lessen these effects , but providing numbers may disadvantage less skilled populations.
RER1 also appears to interact with the ubiquitin ligase NEDD4.
RER1 in human diseased brain tissues co-localizes with αSyn-positive Lewy bodies.
Re-revision of the criterion on functional activity may be warranted to solve its conceptual and operational ambiguities.
Res. 39 ( @number@ ) , 889-894 ( @number@ ) ] .
Rescue of PMN from apoptosis by stimulation with TLR1 was reduced in PMN from older adults.
Rescue paracetamol ( acetaminophen ) up to @number@ g / day was allowed.
Rescuers ( PR = 1.005 , P < 0.001 ) had worse hearing than the KNINEP after age adjustment.
Research about the complexity of nursing practice with this population remains limited.
Research addressing the burden , assessment , and management of nonpain symptoms associated with advanced illness in older adults is limited.
Research and clinical implications are discussed.
Research and development related to TAVR require testing these devices in the calcified heart valves that closely mimic a native calcific valve.
Research and education in the field of aging have grown rapidly over the past few decades , along with variety in research focus and methodology.
Research and interventions should be directed toward better utilization of medicinal drugs.
Research and theory suggest that emotional goals are increasingly prioritized with age.
RESEARCH APPROACH : Individual audiotaped interviews lasting one to two hours.
RESEARCH APPROACH : Qualitative , descriptive study guided by grounded theory.
Research assistants were unaware of the participants ' randomization status.
Research conducted on medical students has often revealed negative attitudes and little interest in geriatrics.
Research considering the relationship between dietary Mg and osteoporosis as well as fractures are sparse and conflicting.
Research continues , as the morbidity and mortality associated with hypertension is better recognized as a threat in aging populations worldwide.
Research continues to uncover molecular mechanisms by which abnormal proteins accumulate in degenerating brain tissue.
Research demonstrates that transgender and nonconforming ( TGNC ) elders face social isolation and discrimination in policies and practices in mental and health care settings.
Research demonstrates the molecular changes underlying the harmful effects of aging , smoking , and obesity seen clinically while demonstrating the variable influence of exercise.
Research demonstrates what only makes sense : teens with tangible support from meaningful adult relationships fare better than those without.
RESEARCH DESIGN : A case-control study of the late auditory evoked potentials using electrophysiological technique was performed.
RESEARCH DESIGN AND METHODS : A cross-sectional registry-based study was conducted using data from the Swedish Dementia Registry ( SveDem ) .
RESEARCH DESIGN AND METHODS : A cross-sectional study of @number@ men ( @number@ participants with type @number@ diabetes and @number@ non-diabetic subjects ) .
RESEARCH DESIGN AND METHODS : A total of @number@ adults were prospectively monitored until @number@
RESEARCH DESIGN AND METHODS : A total of @number@ FDR and @number@ control ( CON ) subjects participated in the study.
RESEARCH DESIGN AND METHODS : The AGES-Reykjavik cohort comprised participants aged 66-96 years with diabetes defined by fasting glucose , medications , or self-report.
RESEARCH DESIGN AND METHODS : The longitudinal Health , Aging , and Body Composition Study included @number@ adults aged 70-79 years at baseline.
RESEARCH DESIGN AND METHODS : The SAT / VAT ratio ( SVR ) was calculated using abdominal computed tomography in @number@ subjects.
RESEARCH DESIGN AND METHODS : This study included @number@ participants , age @number@ years and older from the InCHIANTI study.
RESEARCH DESIGN AND METHODS : Twelve healthy , nondiabetic older subjects ( @number@ ± @number@ years ) were randomized to two groups.
RESEARCH DESIGN AND METHODS : We measured EC production in isolated human and mouse islets and β-cell line in response to glucose and KCl.
RESEARCH DESIGN AND METHODS : We reviewed data on @number@ men , @number@ premenopausal women , and @number@ postmenopausal women in Japan.
RESEARCH DESIGN : A population-based survey.
RESEARCH DESIGN : A qualitative design based on interpretive description was adopted.
RESEARCH DESIGN : Correlational.
RESEARCH DESIGN : In the semantic judgment task , participants indicated via button press whether word pairs were a semantic Match or No Match.
RESEARCH DESIGN : Patients were individually randomized into intervention ( n = @number@ ) and usual care group ( n = @number@ ) .
RESEARCH DESIGN : Speech understanding , temporal processing ability , and self-assessed hearing were measured in groups of younger and middle-aged females.
RESEARCH DESIGN : Stimuli consisted of monosyllabic words presented in isolation , and nine-word sentences that varied in syntactic complexity.
RESEARCH DESIGN : We linked 2006-2009 MDS assessments to Medicare Part A skilled nursing facility ( SNF ) data.
Research directions were identified by workshop participants.
Research directly involving people with SCI is needed to further substantiate and refine the findings of this study.
Research employing receptor knockout mice demonstrate that ERα maintains transcription and memory as estradiol levels decline.
Researchers and clinicians can capitalize on this motivational change to combat stereotype threat's negative effects.
Researchers and policy makers should prioritize access to new technologies for older adults.
Researchers and practitioners should be sensitive to issues of family care among such traditional populations in transition.
Researchers are now reporting objective studies examining processes of structural and volumetric changes with age in increasing frequency as well.
Researchers assessed dining rooms for physical and psychosocial aspects that could influence food intake.
Researchers can contribute by studying conditions , under which the strategies explored might deliver solutions for policy-makers.
Researchers can rely either on retrospectively reported or on prospectively measured health changes to identify and quantify recent changes in respondents ' health status.
Researchers can use this method with longer run times to measure the distribution of folate forms in RBCs.
Researchers , clinicians , people with Alzheimer's disease and caregivers are encouraged to adopt the messaging statement and the recommendations in the companion informational resource.
Researchers discussed evidence for themes , and reached consensus on the final themes.
Researchers filled in a \ "Patient Schedule \ " based on a comprehensive set of socio-demographic and clinical variables and standardised assessment tools.
Researchers frequently use the deep knee squat as a motor task in order to evaluate the kinematic performance after total knee arthroplasty.
Researchers have found empirical support for the weathering hypothesis as well as its theorized contribution to racial and ethnic health disparities.
Researchers have gained substantial evidence that advanced glycation end products may play an important role in the processes of physiological aging.
Researchers have not explored when and how providers make this decision with patients.
Researchers have recently started the European Dementia Prevention Initiative ( EDPI ) , an international consortium to improve strategies for preventing dementia.
Researchers have reviewed couple and family therapy journals to determine the extent to which issues concerning older populations are addressed.
Researchers in all three disciplines investigated how music is processed by the brain.
Researchers interested in using the information are invited to contact the principal investigator Seyed Reza Hosseini ( hosseinim46@yahoo.com ) .
Researchers mapped self-reported strengths phrases to Omaha System concepts using existing narratives of @number@ older adults with 12-15 comorbid conditions.
Researchers over the years have clearly demonstrated the shortcomings of traditional restorative treatment and the cycle of repeat interventional care.
Researchers rarely evaluate the magnitude of systematic non-response because of limited access to population data.
Researchers report that hearing loss seems to speed up age-related cognitive decline.
Researchers should carefully examine a wide range of evaluation techniques to select those that will provide the richest insights for their particular project.
Researchers should examine the presence of a causal link between assimilation and health more closely.
Researchers should select measurement tests wisely when assessing health literacy of older adults.
Researchers , students , and clinicians can use this information in developing innovative research to answer important questions within the occupational therapy field.
Researchers suggest that treating hearing loss more aggressively could help delay cognitive decline and dementia.
Researchers telephoned intervention team supervisors every other week.
Researchers were recruited via listservs and snowballing techniques.
Researchers working within both generativist and constructivist frameworks need to develop more detailed theories of acquisition that predict the pattern of acquisition observed.
Researches are needed to confirm that mental QoL of patients with depressive symptoms can be improved by TAVI.
Researches indicated that the Hippo pathway is a key regulator of organ size and is conserved during evolution.
Researches were carried out by means of a scale of an estimation of quality of life MOS-SF-36 in @number@ and @number@ months after the colostomy.
Researches were carried out by means of bio-test method on \ "Cito-expert \ " apparatus.
Research Ethics Committee of the School of Medicine , University of Campinas / UNICAMP ( number @number@.000-08 ) .
Research exploring cognitive processing associated with Williams Syndrome ( WS ) has suggested that executive functioning deficits exist across the developmental spectrum.
Research findings suggest that the rs25531 SNP may influence functional expression of the L allele.
Research findings underline an early vulnerability of the isodendritic core ( IC ) network to AD neurofibrillary lesions.
Research focused on downstream sites has included insulin receptors , IGF-1 receptors , sirtuin activators , inhibitors of mTOR , and polyamines.
Research focusing on patient-centred factors has attracted very little critical attention.
Research focusing on this area may provide valuable insights into OA pathogenesis.
Research groups around the world have investigated the contribution of gut microbial communities to human health and well-being.
Research has also been limited by comparing different patients in separate age groups rather than the same patients over time.
Research has also indicated that self-affirmation may be a useful supplementary or alternative intervention technique.
Research has been inconclusive so far about the factors responsible for the transition from MCI to dementia.
Research has begun to focus on the ways in which stress contributes to telomere attrition.
Research has begun to investigate the possibility of using natural compounds as a therapeutic intervention following TBI.
Research has consistently shown that despite aging-related losses , older adults have high levels of emotional well-being relative to those in young and midlife adults.
Research has demonstrated that many older adults self-report aging successfully regardless of clinical health status.
Research has demonstrated that nonprofit PACE provides quality , cost-effective community-based care to older adults who would otherwise require a nursing home level of care.
Research has demonstrated that on-the-job injuries result in increased absenteeism , and fatalities are more common for the elder adult population.
Research has focused primarily on anti-inflammatory agents to temper this toxic effect.
Research has highlighted @number@ principal risk factors for progression of arthritis-related biopsychosocial symptoms : age and physical inactivity.
Research has not delineated concrete behavioral strategies to guide providers to communicate with personnel in other organizations to coordinate care.
Research has not examined how frequently such behaviors occur and what factors are associated with these behaviors.
Research has only begun to examine the role of autophagy in the visual system.
Research has provided convincing evidence of a link between healthy eating patterns and healthy aging.
Research has shown age-related impairments to VWM encoding , but aging is likely to affect multiple stages of VWM.
Research has shown that men and women often experience neighbourhood environments differently and that these variations are often reflected in health outcomes.
Research has shown that nonspatial features , including semantic categories , can bias younger adults ' spatial location memory.
Research has shown that poly ( ADP-ribose ) polymerase-1 ( PARP-1 ) and subtelomeric methylation play a role in telomere stability.
Research has shown that social participation decreases in older adults.
Research has suggested that functional abilities are compromised in MCI , but the degree of impairment and underlying mechanisms remain poorly understood.
Research indicates that community engagement is strongly associated with health and well-being in late life.
Research indicates that greater involvement in activities is essential for successful aging.
Research indicates that technology can assist with this goal.
Research indicates that the presence of any of these depressive symptoms negatively impacts the lives of patients suffering from schizophrenia-spectrum disorders.
Research information regarding the correlation between thoracolumbar curvatures and a comprehensive examination of respiratory function parameters in older adults is limited.
Researching genetic factors involved in Parkinson's disease ( PD ) is crucial to increase our knowledge about the pathophysiology of the disorder.
Research in mammals has mainly focused on SIRT1 , the closest homologue of Sir2.
Research in Spain and Europe ' Workshop.
Research in telomere biology may reveal new ways of estimating cardiovascular aging and risk.
Research in the past has focused on the enhanced susceptibility of G6PD-deficient cells or individuals to oxidative challenge.
Research in this area of molecular ecology has so far focused on a limited range of age biomarkers.
Research into Alzheimer's disease has long focused on cognitive impairments.
Research into its nature has provided valuable insights into understanding molecular mechanisms underlying cell senescence.
Research into the age-associated decline in the immune system has focused on the factors that contribute to the accumulation of senescent CD8 T cells.
Research into the effectiveness of mindfulness-based interventions ( MBI ) in age-related conditions and disorders is still in its infancy.
Research into the genetic component of human longevity can provide important insights in mechanisms that may protect against age-related diseases and multi-morbidity.
Research into the use of clozapine in older people is somewhat scarce.
Research into tissue engineering and electrical reanimation offers future options for treatment of presbyphonia.
Research is needed on how to increase LTPA and to identify modifiable factors that could enhance their participation.
Research is needed to determine the chronic effects of cycling on aBMD and interventions that improve aBMD in this population.
Research is needed to determine the physiological and behavioral pathways through which SLE and hassles differentially affect mortality.
Research is needed to examine the association between elder abuse and cardiovascular disease.
Research is needed to explore strategies to enhance capacity to deliver quality radiation therapy despite increased patient loads.
Research is needed to identify the factors that predict the development of premature frailty among HIV-infected persons and the optimal prevention and management strategies.
Research is urgently needed to determine the optimal treatment of the aged patient.
Research is warranted to elucidate the physiological and molecular basis for rapid muscle loss during short periods of disuse.
RESEARCH METHODS : Participants were randomly assigned to either a ten-session support group or a control group.
Research needs regarding the safety , efficacy , and application of clinical interventions related to these topics also are discussed.
Research nurses completed a standardized comprehensive assessment of residents and interviewed family caregivers at baseline ( 2006-2008 ) and @number@ year later.
Research nurses completed comprehensive resident assessments at baseline ( 2006-2007 ) .
Research nurses completed interRAI-AL resident assessments and interviewed family caregivers and administrators.
Research of direct-to-consumer hearing devices is limited , and current published studies are of weak quality.
Research on AD has undergone a paradigm shift from viewing it as a disease of old age to taking a life course perspective.
Research on age differences in emotional responses to daily stress has produced inconsistent findings.
Research on age-related cognitive change traditionally focuses on either development or aging , where development ends with adulthood and aging begins around @number@ years.
Research on aging and vision has increased dramatically over the past few decades.
Research on aging and visual search often requires older people to search computer screens for target letters or numbers.
Research on automatic processes underlying PA behaviour in physically inactive older adults is yet non-existing.
Research on brain plasticity and its relationship to experiential changes gathers momentum and attracts significant public interest.
Research on delphinidins showed improved endothelial function with elevated endothelial NO generation , lowered platelet aggregability and anti-inflammatory vascular effects.
Research on dementia care continues to develop , yet little attention has been given to the dementia experience in rural , northern communities.
Research on falls in elderly people has a great social significance because of the rapidly growing of the aging population.
Research on human brain changes during skill acquisition has revealed brain volume expansion in task-relevant areas.
Research on larger survey samples to distinguish different work exit routes and reasons for spouses ' joint work exits appears warranted.
Research on low-threshold PA interventions for users of residential aged care and documentation of their sustainability are scarce.
Research on new casinos typically focuses upon their impact on the community , rather than on specific at-risk groups.
Research on older adults ' use of the Internet has merely focused on users versus nonusers and consequences of Internet use and nonuse.
Research on retrieval-induced forgetting has shown that remembering can cause forgetting of related information.
Research on sarcopenia prevention and treatment is developing quickly , but many questions are still unanswered.
Research on the influence of ageing on hair properties will enable a detailed understanding of the natural ageing process.
Research on the link between APOEε4 and neuropsychiatric symptoms ( NPS ) in Alzheimer's disease ( AD ) has been inconsistent.
Research on the phenomenon has focused mainly on individual and dyadic perspectives of the repartnered.
Research on the use of health care by older newly-diagnosed cancer patients is sparse.
Research on this topic should embrace a range of potential influences , including perceptions of one's neighborhood and region.
Research on trust in health care faces two enduring challenges.
Research on vascular endothelial cell ageing helps elucidate the pathogenesis of diseases associated with cell ageing.
Research on widowhood mostly emphasizes negative outcomes , but some studies suggest widows are resilient.
Research performed in the last few years has revealed important roles for the spatial and temporal organization of the genome on genome function and integrity.
Research productivity was measured through abstracts , publications , and investigator-initiated projects.
Research proposals for federal funding increased from @number@ to @number@ with success rate of @percent@.
RESEARCH QUESTION : Is the program more effective and cost-effective than usual care for the prevention of falls ?
Research questions to advance frailty research into specialty medicine are proposed.
Research reached the conclusion that the young elderly with new needs and expectations are highly different from those of their pervious generations.
Research results are heterogeneous because of the multifactorial features of schizophrenia and the multiplicity of the methodological approaches adopted.
Research results based on different FS cannot be compared or pooled.
Research reveals that older people do a significant amount of volunteer work.
Research should also focus on the reasons for discrepant findings related to age-associated changes in different components of individual wisdom.
Research should examine the etiology of clinicians ' age expectations and their association with older adult diagnoses and treatment.
Research should investigate the possibility of finding ways to boost HDL-C levels to potentially promote cognitive function.
Research shows that BPD symptoms decrease in severity over time.
Research shows that elderly patients are fully capable of benefiting from psychotherapy , and often prefer this non-pharmacological treatment option.
Research shows that negative cognitive styles are associated with increased stress reactivity , low mood and accelerated cellular aging.
Research shows that older persons ' self-determination is not fully respected within the healthcare sector.
Research staff conducted standardized observations during and between meals for @number@ months.
Research studies were sought to identify key health determinants and evidence-based options for preventing social isolation.
Research substantiating the efficacy of vitamins C and E and of selenium will be reviewed.
Research suggests that human flourishing is associated with positive outcomes for mental and physical health.
Research suggests that in the elderly , the presence of comorbidities may impact the muscle mass / strength relationship.
Research suggests that the drug rapamycin slows mammalian aging , but a provocative new study has gained attention by claiming to show it does not.
Research suggests that there is a strong relationship between knee pain and loss of physical function.
Research suggests that this increased risk is associated with declines in contrast sensitivity and visual acuity.
Research suggests that youth aging out of foster care may be at higher risk of experiencing homelessness than other youth.
RESEARCH TEAM : Two pharmacists were responsible for the selection and adaptation of QIs.
Research to address the important goal of understanding key sex differences in cardiometabolic disease across the life span is lacking.
Research to date has rarely included elderly women , hence little is known about the risk of diabetes after statin exposure in this population.
Research to develop interventions to preserve quality of life should focus on this high-risk subpopulation.
Research to examine therapy delivered within the home environment has the potential to expedite relearning of function and reduce health care expenditures.
Research to explore this predicted shortage has focused on reasons why social work students do not appear interested in working with the older population.
Research to identify whether dizziness is a geriatric syndrome has largely overlooked often treatable vestibular causes.
Research using both human and animal models in the past several years has clearly indicated that genetics is associated with physical activity.
Research was conducted in the Virtual Health Library and Scopus databases , examining publications since @number@
Research was conducted in urban and rural areas of the city Telavi in 2012-2013.
Research within the domain of spatial working memory has not conclusively determined whether age differences exist.
Resected specimen were measured with respect to average surface and volume.
Resective epilepsy surgery ( RES ) has traditionally been offered to young patients ( < 50years ) .
Resequencing of RTS and LFS patients ' mitochondrial genome reveals common mutations indicating similar mechanisms of regulation by RECQL4 and p53.
Resequencing the IL10 gene region did not uncover any additional common variants in the pro-inflammatory haplotype to those SNPs that were initially genotyped.
Reservations stem from unproven superiority along with an increased incidence of adverse events.
Reserve is challenging to study for two reasons.
Reservoir-wave analysis was performed and indices of arterial function , including the systolic and diastolic rate constants , were derived.
Resetting circadian rhythms leads to well being and increased life span , while clock disruption is associated with increased morbidity accelerated aging.
Resetting or repairing the epigenome of aging cells in intact animals may rejuvenate the cells and perhaps the entire organism.
[ Res Gerontol Nurs.
[ Res Gerontol Nurs.
Residence and time spent with primary caregiver were associated with participation in physical leisure activity.
Residence in an immigrant enclave was protective of prevalent CI among FB-MA.
Residence ( rural and urban ) did not appear to influence the prevalence of chronic back pain and arthritis / joints pain.
Residency participants also perceived the residency as beneficial.
Resident and nursing home factors associated with SNF admission were identified using hierarchical multivariable logistic regression.
Resident data were collected baseline and at two follow-ups using validated scales and record reviews.
Resident-family dyads were the primary unit of analysis , and all analyses used intention-to-treat assignment.
Residential addresses at birth and in young adulthood were geocoded and residential traffic and greenness exposure was determined.
Residential BC exposure levels were estimated using a spatiotemporal land use regression model.
Residential exposure to traffic noise was modelled at the facade according to the EU Directive 2002 / 49 / EC.
Residential older adults within the High Presence High Search cluster scored in-between the two other clusters for depressive symptoms.
Resident involvement in residential care homes is a challenge due to shortcomings of consumerist and formal approaches such as resident councils.
Resident microglial cells can be regarded as the immunological watchdogs of the brain and the retina.
Resident ( n = @number@ ) symptoms , activities and thriving were assessed by staff using a study survey based on established questionnaires.
Residents aged @number@ or older meeting the inclusion / exclusion criteria in all the homes are eligible to participate.
Residents are frequently frail with substantial co-morbidity , functional and cognitive impairment with high susceptibility to acute illness.
Residents developed actions ( gallery parties and a buddy project ) to strengthen social interactions and realized these with the help of volunteers and professionals.
Residents evaluated the experience.
Residents from the other four nursing homes ( control ) received usual care.
Residents gave lower ratings to other aspects such as autonomy , staff-resident bonding , and personal relationships.
Residents had contact with the NHS on average once per month.
Residents in communities with 4 25 beds were more racially diverse than residents in larger communities.
Residents in overweight were those whose food consumption relative to their weight was the lowest.
Residents ( n = @number@ ) living in public or private long-term care settings were interviewed using unstructured interviews.
Residents of Canada's rural and remote communities know the challenges associated with accessing consistent healthcare.
Residents of rural areas , manual workers , and smokers had significantly higher anthropometric indices.
Residents of rural areas , manual workers , and smokers have significantly higher anthropometric indices.
Residents reported feeling comfortable when indoor temperature approximated @number@ °C. As living room temperature increased , indoor thermal comfort decreased.
Residents , significant others , and staff from nine LTC facilities participated in these focus groups.
Residents ' subjective assessment of the HIT intervention were generally positive.
Residents were chiefly over age @number@ female , and with an age-related dementia.
Residents were least likely to be involved in the decision , yet most likely to support transfer.
Residents were prescribed a mean ± SD @number@ ± @number@ medications.
Residents with a higher number of PIDPs had a higher likelihood of being hospitalized.
Residents with diabetes had more skin problems , used more medication , their cognitive performance was better and their involvement in activities greater.
Residents with PIMs were identified by using Screening Tool of Older Person's potentially inappropriate Prescriptions ( STOPP ) criteria.
Resident-to-resident elder mistreatment ( R-REM ) in nursing homes is frequent and leads to adverse outcomes.
Residual confounding is still a problem in many of the observational studies reviewed.
Residual genetic heritability of serum sclerostin was @number@ ( P < @number@ ) .
Residualized change regression analysis was conducted.
Residual stresses in @number@ of the self-adhesive cements and the polyacid-modified composite aged in wet conditions resulted in a net expansion.
Residues that are most susceptible to isomerization are identified site-specifically and are found to reside in structurally disordered regions.
Resilience is described as the ability to achieve , retain , or regain a level of physical or emotional health after illness or loss.
Resilience is often considered both a trait and a process.
Resilience metrics were defined at baseline by examining the residuals when regressing brain aging outcomes ( hippocampal volume and cognition ) on CSF biomarkers.
Resilience scores as measured by the CD-RISC did not correlate with functional improvements during rehabilitation postfracture.
Resilience scores varied from 49-92 , with an average of @number@ representing overall high resilience compared to general population samples.
Resilience was assessed with the 10-item Connor-Davidson Resilience Scale , capturing the ability to cope with adversity.
Resilient carers were knowledgeable and well supported by family but especially friends , with whom they shared this knowledge.
Resilient men had higher physical activity , significantly lower C-reactive protein levels , and @number@ percent had lower cardiac-disease risk compared to nonresilient men.
' Resilient older people' , with high life satisfaction despite repeated depressive episodes , reported benefit from strategies dealing with adversity , including depression.
Resin cements were applied to prepolymerized indirect resin disks , which were bonded to the dentin surfaces and light polymerized.
Resin-dentin beams were prepared for bond strength and TEM evaluation after @number@ hrs and after aging in artificial saliva for @number@ and @number@ mos.
Resin tags were larger and more numerous for young dentin.
RES is obtained from the skins of grapes and other fruits and berries.
Resistance exercise alone or combined with any other form of exercise was not found to have any significant effect on CV markers.
Resistance exercise also induced a decrease in NLRP3 expression and in the caspase-1 / procaspase-1 ratio.
Resistance exercise has been proposed as a viable intervention to elicit muscular adaptation and improve function.
Resistance exercise has been shown to increase in plasma sex steroid hormone levels.
Resistance exercise performed in the fasted state stimulates mixed MPS within @number@ h after exercise , which can remain elevated for @number@ h.
Resistance exercise ( RE ) stimulates protein synthesis ; however , a postexercise accumulation of unfolded proteins may activate the UPR.
Resistance exercise training seems to influence functional performance adaptation.
Resistance to oxidative stress was measured by the F2-isoprostane response to forearm ischemia / reperfusion ( I / R ) trial.
Resistance toward CD95-mediated apoptosis is a hallmark of many different malignancies , as it is known from primary chronic lymphocytic leukemia ( CLL ) cells.
Resistance training also improves walking ability ( gait speed ) in older adults.
Resistance training appears to be more efficient in reducing blood leptin level than aerobic training alone.
Resistance training has been known to be effective to maintain and improve bone mineral density ( BMD ) and bone strength.
Resistance training improves a decrease in BMD through an enhancement of bone formation and a suppression of bone resorption.
Resistance training in combination with other types of exercise might be effective for maintaining BMD in patients with osteoporosis.
Resistance training is recommended for all adults of both sexes.
Resistance training is well established to increase aging muscle mass and strength.
Resistance training may assist in maintaining or improving muscle volume and reducing low-grade inflammation.
Resistance training may provide additional benefit.
Resistance training produces several physiological adaptations which improve aging musculoskeletal health , such as increased muscle and bone mass and strength.
Resistance training remains the most effective intervention for sarcopenia ; however , older people maybe unable or unwilling to embark on strenuous exercise training programs.
Resistance training resulted in significant increases in strength that were not evident in the flexibility intervention.
Resistance training ( RT ) has been shown to promote metabolic and functional benefits in this population.
Resistance-type exercise training represents an effective strategy to increase satellite cell content and reverse type II muscle fiber atrophy.
Resistant hypertension is a relevant condition gaining special attention given its clinical and economic impact.
Resistant hypertension was more frequent in people who were older , obese , male , African American or nonblack Hispanic.
RES may extend human lifespan by activating the sirtuins and SIRT1 molecules.
Resolution , as defined by correlations between item-by-item performance and confidence judgments , was age-invariant.
Resolution of delirium may require more-intense nonpharmacological management when the individual has dementia.
RESOLUTION : This project was conducted between @date@ and @date@ .
Resolving the bases for different physiological functioning or exercise performance within a population is dependent on our understanding of control mechanisms.
RESON.
RESON.
Resorption occurred earlier at the inferolateral orbital rim followed by the superomedial orbital rim in later decades of life.
Resorption pit density and percent resorption area demonstrated negative age-adjusted correlation with diffuse damage.
Resorption pit density , average resorption pit area , and percent resorption area were quantified in samples from @number@ common donors with AGE measurements.
Resource allocation in one facility is often made with an approximate knowledge of its impact on other facilities nearby.
Resource constrains have increased the importance of understanding rising emergency admissions , which in policy discourse is often explained by population aging.
Respective HRs were @number@ ( @number@ % CI @number@.82-1.13 ) for men and @number@ ( @number@ % CI @number@.65-0.85 ) for women.
Respiration in EndoC-βH1 cells was more similar to that in human islets than in INS-1 832 / 13 cells.
Respiration was scored according to AASM @number@ and @number@ criteria in order to compare both methods.
Respiratory activity was not significantly altered with donor age , probably reflecting genetic variation.
Respiratory and circulatory complications occurred more frequently after operations.
Respiratory capacity per mitochondrion is not decreased with insulin resistance.
Respiratory control ratio of mitochondria from infected cells was significantly lower than that of normal cells.
Respiratory control ratios were measured from mitochondria isolated from leg skeletal muscle biopsies from one subset.
Respiratory disorders and sleep disorders must be looked for : respiratory insufficiency , sleep-related breathing disorders such as sleep apnea , restless legs syndrome.
Respiratory disturbances positively correlated with right amygdala volume , and more severe sleep fragmentation was associated with increased thickness of the right inferior frontal gyrus.
Respiratory failure remains the most common indication for ICU admission.
Respiratory infections are a leading cause of infectious disease burden worldwide especially among the elderly.
Respiratory infections are among the most important causes of morbidity and mortality from infectious diseases worldwide.
Respiratory muscle strength is known to affect pulmonary functions.
Respiratory muscle strength was based on maximal inspiratory pressure and expiratory pressure and leg strength based on hand-held dynamometry.
Respiratory patterns of @number@ patients were grouped based on the combination of the regularity of amplitude , period , and baseline positions.
Respiratory syncytial virus ( RSV ) is a leading cause of severe virus-induced respiratory disease in individuals over the age of @number@
Respiratory system resistance and dynamic compliance were not related to the ageing process.
Respiratory tract infections exacerbate asthma in older patients and possibly play a role in the pathogenesis of late-onset asthma.
Respiratory viruses appear to cause severe disease in the older transplant population.
Respiratory viruses are generally a long-term complication of transplantation and primarily acquired in the community.
Respiratory virus infections in the elderly result in increased rates of hospitalization and death.
Respondents aged ≥60 were selected ( N = @number@ ) for analysis.
Respondents also raised issues related to safety , maintenance , and management of OFE.
Respondents also wore a step pedometer over @number@ consecutive days to estimate average daily steps.
Respondents believed the most helpful treatments for depression were increasing physical activity , counseling , and antidepressant medication.
Respondents came up with a set of specifications in terms of the operation and the design of the technology.
Respondents completed a detailed interview at home and underwent a 5-min baseline electrocardiograph recording as part of a clinic-based health assessment.
Respondents endorsed higher social motives for drinking and lower coping motives.
Respondents formerly exposed to iso-strain had significantly higher diastolic blood pressure and more often hypertension.
Respondents generally viewed themselves as competent clinicians with improved ability to relate to patients and staff and little decline in procedural skills.
Respondents indicated more disengagement from CAII-R subscales Active Instrumental ( AI ) and Active Social ( AS ) and increased engagement in Passive Social Spiritual.
Respondents indicated their agreement / disagreement with seven PA motivators and @number@ PA context preferences.
Respondents in four age cohorts were selected for comparison.
Respondents in poorer wealth quintiles in China were more likely to use DM medications whereas the reverse was true in India.
Respondents overrepresented minority , disadvantaged groups.
Respondents received a vignette that raised issues related to parental dementia.
Respondents recommended more applied coursework and assistance with career planning to enhance employment opportunities upon graduation.
Respondents reported their smoking status , health conditions and healthcare expenditures.
Respondents ' self-identified needs included access to health care , dealing with pain , anticipated grief due to friends dying , and maintaining independence.
Respondents underestimated the prevalence of these disorders and were significantly worse at estimating the prevalence of PFD than ED.
Respondents were additionally asked about their current general health , income , education , marital status , age and gender.
Respondents were asked to complete the OHI before and @number@ months after implementing PEP.
Respondents were classified into five cognitive functioning categories.
Respondents were classified into one of five birth cohorts : 1918-1927 ; 1928-1937 ; 1938-1947 ; 1948-1957 ; 1958-1967.
Respondents were comparable to the recruitment pool on most demographic characteristics and health assessments.
Respondents were concerned about their aging bodies , potential dependency on others , and loss of autonomy.
Respondents were divided into a younger and older group at the median of @number@ years which equals the average retirement age in the Netherlands.
Respondents were measured every three years.
Respondents were white , mostly female , and averaged @number@ years in age.
Respondents who died during the 3-year period were assigned to a third outcome category.
Respondents who increased their level of attendance from @number@ to @number@ also exhibited lower rates of smoking in @number@
Respondents with advance directives also were more likely to report having a chronic disease and a regular source of care.
Respondents with functional limitations and disabilities were @number@ times and @number@ times respectively , more likely to report poor health.
Respondents with higher psychological distress , higher education , and more frequent Internet use were significantly more likely to consider using Internet treatments.
Respondents with other musculoskeletal pain problems than fibromyalgia were divided into two groups with respectively localized and widespread musculoskeletal pain.
Responder rate by physician-rating severity at maximal contraction at week @number@ was @percent@ in the DWP450 group and @percent@ in OBoNT group.
Responder rates did not differ until week @number@ ( @number@ U , @percent@ ; @number@ U , @percent@ ; p = @number@ ) .
Responder rates ( for each region ) and mean wrinkle scores ( whole upper face ) were calculated.
Responder rates generally peaked at Days @number@ to @number@
Responder rates on other end points also significantly favored onabotulinumtoxinA treatments.
Responding to change ranged from resisting , to being in a holding pattern , to transforming and adapting.
Response and remission rates did not differ between groups.
Response of the UES to injury , reflux , and surgical interventions is reported.
Response rates and remission rates were also similar.
Response rates at rest were lower for both products.
Response rates for the FLSQ were @percent@ and @percent@ at baseline and follow-up , respectively ; no items had excessive missing data.
Response rates were higher at maximum tension than at rest.
Response rate was @percent@ ( N = @number@ ) .
Responses highlighted healthcare system-based barriers related to hospital / ICU policy and workflow.
Responses of our model in terms of changes in central pressure waveform with arterial alterations were consistent with previously described physiological knowledge.
Responses to body removal and staff notification varied , but negative experiences were reported by a substantial minority.
Responses to questionnaires and the group's opinions on definitions specified in the literature were used to guide the discussion.
Responses to this question form the data set for the present study.
Responses to various types of vaccination are often higher among women thereby also mounting stronger humoral responses.
Responses were classified into low- , medium- , and high-knowledge groups.
Responses were quantified on a Likert scale.
Responses were received from @number@ respondents , a response rate of @percent@.
Responses were recorded , transcribed and then analyzed.
Responses were transcribed verbatim , coded , and clustered.
Response time , accuracy and dual-task costs ( % change in multi-task condition ) were determined.
Response times revealed an inverted U shape in performance with age.
Response time was compared with control conditions that did not require resolving competition.
Response to antiepileptic drugs is less evident.
Response to mechanical stimulus , including blood pressure regulation as a typical example , is essential for cardiovascular homeostasis.
Response to psychiatric medications in later life is highly heterogeneous and complex.
Response to therapy was defined according to the National Institute for Health and Clinical Excellence criteria.
Response was seen in @percent@ ( @percent@ complete remissions ) .
Responsiveness appears to be excellent.
Responsiveness of both instruments seems to be poor.
RES supplementation prior to age-related bone loss was beneficial.
Resting and squeezing pressures were lower in those patients not satisfied , but data are not statistically significant.
Resting blood pressure ( BP ) , endothelial function , and blood biomarkers were measured for @number@ h postintervention.
Resting blood pressure did not influence the effect of brief Valsalva manoeuvre on transmural pressure.
Resting CBF ( milliliters per @number@ grams per minute ) and hypercapnia-induced CVR were quantified from pseudo-continuous arterial spin-labeling MRI.
Resting ECG does not give clinically significant additional information for the assessment in subjects without overt cardiac disease.
Resting ECG of @number@ young and @number@ elderly healthy subjects were analyzed.
Resting EEG records from @number@ age-matched participants ( mean age @number@ years ) -15 normal controls , @number@ MCI , and @number@ early AD-are examined.
Resting energy expenditure was lower in the 2nd and 3rd groups of children.
Resting heart rate is a heritable trait , and an increase in heart rate is associated with increased mortality risk.
Resting insulin sensitivity and JH2O2 during complex-I leak respiration were positively correlated ( r = @number@ P < 0.05 ) .
Resting state components were extracted after spatial normalization in individual patients with independent component analysis.
Resting state executive control network ( RS-ECN ) represents a novel approach to interrogate the integrity of brain areas underlying executive dysfunction.
Resting-state eyes-closed EEG rhythms were recorded in @number@ healthy elderly ( Nold ) , @number@ MCI , and @number@ AD subjects.
Resting state fMRI studies have found that cognitive decline in aging is associated with alterations in functional connectivity of distributed neural systems in the brain.
Resting state functional connectivity magnetic resonance imaging has demonstrated that brain networks degrade during symptomatic AD.
Resting-state functional magnetic resonance image is a useful technique for investigating brain functional connectivity at rest.
Resting-state functional magnetic resonance image ( rs-fMRI ) is increasingly used to study functional brain networks.
Resting-state functional magnetic resonance imaging reflects spontaneous brain activity and / or the endogenous / background neurophysiological process of the human brain.
Resting-state network maps were extracted with independent component analysis and group-level statistical analyses were performed to detect disease and disease-by-age interaction effects.
REST is a master regulator of neurogenesis and neuronal differentiation that has not been previously implicated in Alzheimer's disease.
Restoration of ATPIF1 in Rho0 cells , which lack mtDNA and a functional electron transport chain , lowers ΔΨ and triggers PARK2 recruitment.
Restoration of barrier function by targeting sgp130 may be a novel treatment strategy.
Restoration of CDK5 and autophagy were associated with reduced neurodegeneration and behavioral alterations.
Restoration of occupational health system in Russia is of crucial importance.
Restoration of TβRII and SMAD3 together , but not separately , reinstates TGF-β signaling and increases CTGF / CCN2 and type I collagen levels.
Restorative strategies after stroke are focused on the remodeling of cerebral endothelial cells and brain parenchymal cells.
Restoring binocularity in children with amblyopia may improve their poor hand action control.
Restoring Dicer levels and the diurnal patterns of Dicer-controlled miRNA and RNA expression may provide new therapeutic strategies for metabolic disease and aging-associated complications.
Restoring NAD⁺ levels may be beneficial throughout the organism.
Restricted activity was related to chronic conditions , such as cardiovascular diseases , cerebrovascular accident and so on.
Restricted breathing was revealed by spirometry in @percent@ and obstructive breathing in @percent@ of patients.
Restricted licenses were associated with reduced number of miles driven per week.
Restricted to walking pace , will play still be engaging ?
Restricting the control group accentuated these differentials.
Restricting to events > 2 Mb in size , we observed an increase in event frequency as event size decreased.
Restriction of the use of multifocal glasses may reduce falls in active older people.
Restrictions in participation were present in @percent@ of patients.
Restrictions on resident physician practice hours have impacted inpatient care as well.
Restrictions were often rationalised as normal in older age , although co-existing accounts of perseverance and frustration with limitation were also evident.
Restriction to various birth cohorts , known zygosity and known type @number@ diabetes did not alter the overall conclusions.
Rest tremor seems to emerge as a clinical feature with advancing disease.
Rest tremor was evaluated in several positions ( seated , standing , lying down ) .
Rest tremor was restricted to the arms and was not observed in the legs.
Restylane Vital® injector offers more predictable results and a lower incidence of adverse effects than more commonly used techniques.
RESULTADOS : A prevalência de pelo menos um medicamento de uso crônico entre idosos foi de @percent@.
RESULTADOS : Foi observado aumento da proporção do uso de anti-hipertensivo , de @percent@ em @number@ para @percent@ em @number@ chegando à @percent@ em @number@
RESULTADOS : Na primeira etapa , agruparam-se por nível de similitude os problemas identificados , constituindo-se um corpo de @number@ problemas para análise.
RESULT : Age was @number@ + / - @number@ years ( range @number@ - @number@ ) .
Result applicability is limited by only including English studies.
RESULT : Both the level of personal mastery and perceived constraints predicted SMC.
RESULT : CR increased the expression of LIF through the / protein kinase B ( PI-3K / AKT ) signaling pathway in Ishikawa cells.
RESULT : Data indicated lower levels of perceived stress , depression and loneliness across participants.
RESULT : IL1β expression was enhanced over 580-fold in articular chondrocytes treated with IL-1β and OSM.
Resulting age trajectories of all-diseases mortality show a strong minimum that is hidden in all-causes mortality.
Resulting Ns were @number@ D + T + , @number@ D + T- , @number@ D-T + , and @number@ D-T-.
RESULT : In mixed models the intervention was related to slower global cognitive decline in the intervention group ( p = @number@ ) .
RESULT : Material deprivation was not associated with either the hours of home care received or the receipt of supportive home care services.
RESULT : PGC-1alpha , SIRT1 and SIRT3 protein expression was similar regardless of the level of adiposity.
Results.
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RESULTS : .
RESULTS : .
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RESULTS : 1920-1930s : suction , electro-surgery , kilovolt ( KV ) irradiation.
RESULTS : 23-HTA showed antioxidant capacity mediated by ROS scavenging and regulation of antioxidant-related gene expression.
RESULTS : 25OHD levels ≥20 ng / ml were found to be associated with better lower extremity muscle function and strength.
RESULTS : 30-day mortality data were available for @number@ of @number@ patients.
RESULTS : 3-Stimulus oddball task : Behavioural : accuracy and reaction time of responses to targets were not affected by exposure.
RESULTS : 529 ( @percent@ ) participants were identified to have MCI.
RESULTS : 8-OHdG and p16 increased but Klotho decreased with progression of pathologic grade.
RESULTS : A 3-mm Endotine browlift device was placed in most patients ( @number@ @percent@ ) .
RESULTS : A 5-class solution was selected.
RESULTS : AADI significantly increased from extension to flexion posture , however , no significant differences were observed in every posture among the groups.
Results : about @number@ participants were included and @number@ participants had diagnosis of incident LLD.
RESULTS : About @number@ patients were considered for controlled DCD and @number@ ( @percent@ ) became donors.
RESULTS : About @number@ subjects completed at least one of the two questionnaires.
RESULTS : About @percent@ of home care clients in Europe suffer from mild-to-moderate cognitive impairment.
RESULTS : About @percent@ of older Chinese adults reported feeling lonely , and lonely adults faced increased risks of dying over the subsequent years.
RESULTS : About @percent@ of older people refrained from buying prescribed medications.
RESULTS : About @percent@ of primary care patients are likely to meet criteria for MDD.
RESULTS : About @percent@ of the respondents were found to have MCI.
Results : About @percent@ of the sample reported having experienced discrimination.
RESULTS : About @percent@ of variability in memory and executive function declines was explained by ventricular volume progression among mild cognitive impairment patients.
RESULTS : A BRAF mutational result was obtained in @number@ cases.
RESULTS : Absence of hip , knee , and hand OA was seen in @number@ @number@ and @percent@ of participants , respectively.
RESULTS : Absolute numbers of Tregs were similar in both groups at rest.
RESULTS : According to the data , our study confirms the anatomic feasibility of a BF.
RESULTS : according to the EWGSOP algorithm , @percent@ of the participants were classified in the sarcopenia group.
Results According to the LEMG analysis , @number@ patients ( @percent@ ) had synkinesis , and @number@ ( @percent@ ) did not.
RESULTS : Accounts of decisions to initiate contact with physicians support prior research.
RESULTS : Accuracy and speed for cognitive tasks were significantly impaired when visual input was degraded.
RESULTS : Accuracy improved from young children to young adults ; from young to older adults , the pattern reversed slightly.
RESULTS : Acid sphingomyelinase activity in pRBCs was associated with the formation of ceramide and the release of microparticles.
RESULTS : A clear gender effect was found.
RESULTS : A combined reduced FEV1 and PAD was established in @percent@ ( 78 / 1307 ) of participants.
RESULTS : A consensus was reached after two rounds of consultation for all the items evaluated , where none was judged \ "inappropriate \ ".
RESULTS : A continuity-discontinuity continuum and a value-attribution pole emerged from data analysis.
RESULTS : A Cronbach alfa of @number@ was obtained for the general dimension of successful aging.
RESULTS : Across all cohorts , DNAmage was correlated with chronological age.
RESULTS : Across all four measures , the well-being scores of one spouse were positively and significantly associated with the well-being scores of the other.
RESULTS : Across all negative affect measures , older age was related to lower levels of negative affect.
RESULTS : Across groups , TPA decreased an average of @number@ min·wk annually.
RESULTS : Across the full sample , @percent@ of participants screened positive for depression.
RESULTS : ACTH / cortisol was a negative biomarker for age in female patients.
RESULTS : Active coping and good mental and especially physical health predicted high work ability at follow-up.
RESULTS : Active plaques were most often found in early disease , whereas at later stages , smoldering , inactive , and shadow plaques predominated.
RESULTS : AC tone bursts , clicks and BC tone bursts evoked oVEMPs in @percent@ , @percent@ and @percent@ of ears , respectively.
RESULTS : Acute bowel obstruction was the major complication of CRC that led to an emergency hemicolectomy.
RESULTS : AD developed in @number@ participants.
RESULTS : Addition of measures of cognitive processing speed and executive function to a model of age-related change in aviation performance significantly improved the model.
RESULTS : A decrease in sialylation of glycoproteins and an increase in sialidase NEU1 were observed in LP fibroblasts.
RESULTS : A decrease in SNR level significantly reduced accuracy and increased reaction time in both YAs and OAs.
RESULTS : A deletion of ITPR1 was found in @number@ of @number@ families ( @percent@ ) , corresponding to @number@ patients with SCA15.
RESULTS : Adequate randomization and therapeutic fidelity were achieved.
RESULTS : ADHD diagnosis was associated with being divorced / never married , having less family members in their network , and emotional loneliness.
RESULTS : ADHD effects on EEG strongly depend on age and frequency.
RESULTS : A diagnosis was reached in @percent@ of cases.
RESULTS : A distinct AVM miRNA signature comprising a large portion of lowly expressed miRNAs was identified.
RESULTS : Adjusted Cox proportional hazards models showed a J-shaped relationship between total-E2 and risk of dementia ( p = @number@ ) .
Results : adjusted for demographic characteristics , major depressive disorder was associated with a lower level of executive function in both younger and older adults.
RESULTS : Adjusted logistic regressions indicated that there was no effect of anxiety among older adults with gastrointestinal disease on mental health service use.
RESULTS : Adjusted total and @number@ h EE were not different between C and CR.
RESULTS : Adjusting for age and gender , we observed significant but divergent associations between immigrant generation , acculturation , and diabetes risk.
RESULTS : ADL stage showed strong ordered associations with perceived health , dementia severe enough to require proxy use , and history of stroke.
RESULTS : Adolescents with PLEs ( @percent@ ) had significantly higher risk of suicidal problems than those without PLEs.
RESULTS : A dose-dependent response was observed in young adult participants , but not in elderly participants.
RESULTS : Adult current smoking prevalence for Hispanics was @percent@ compared to @percent@ for all Californians in @number@
RESULTS : Adult rape occurred in @percent@ of the sample.
RESULTS : Adults with SBM had significantly poorer working memory accuracy and overall inhibitory control performance than typical peers.
RESULTS : Advanced age , left ventricular systolic impairment , and renal impairment were frequently encountered.
RESULTS : Advanced glycation end product-exposed RPE monolayers presented significantly decreased cystatin C expression and secretion.
RESULTS : Advanced histopathology , including myocytolysis and / or fragmentation of muscle bundles , was frequently observed in patients with poor prognosis.
RESULTS : Advanced neoplasms were found in @number@ users ( @percent@ ) and @number@ nonusers ( @percent@ ) of low-dose aspirin.
RESULTS : Adverse childhood events were associated with loneliness by both men and women.
RESULTS : Adverse drug reaction-related repeat admissions occurred after @percent@ ( n = @number@ ) of @number@ adverse drug reaction-related index admissions.
RESULTS : Adverse events were similar across treatment groups with the most common being arthralgia , joint swelling , back pain , and joint stiffness.
RESULTS : AEDs were used by @percent@ of the community-dwelling and @percent@ of the institutionalized elderly.
RESULTS : AED was significantly higher in controls compared to the BPH patients.
RESULTS : Aesthetically pleasing eyebrow and forehead with reduced power in the frowning muscles were achieved in the majority of patients in both groups.
RESULTS : AF associated patients were older , more frequently disabled , and characterized by greater comorbidity and longer in-hospital length of stay.
RESULTS : AFAST-I shows a high level of internal homogeneity with a Cronbach's α coefficient of @number@
RESULTS : A five-factor coping solution emerged : stoicism , refocusing , problem-solving , wishful-thinking , and emotion-focused coping.
RESULTS : African Americans and low-SES individuals lost more confidants especially due to death than did whites and college-educated respondents.
RESULTS : African Americans reported substantially lower healthcare trust than non-Hispanic whites ( P < .001 ) .
RESULTS : After adjusting for covariates , QOL was significantly associated with neighborhood safety and social cohesion.
Results : After adjusting for covariates , results indicated significant association between higher social support and higher utilization of cancer screenings.
RESULTS : After adjustment for obesity-related cardio-metabolic parameters , higher BMI and larger WC at midlife predicted lower executive function.
RESULTS : After adjustment , significant relationships were found between average peak expiratory flow rate ( APEFR ) and cognitive performance measures.
RESULTS : After age @number@ people are progressively less likely to divest themselves of belongings.
RESULTS : After ALA-PDT or red light illumination , the appearance of photoaging lesions improved , SC hydration increased and TEWL decreased.
RESULTS : After a mean follow-up of @number@.6±1.2 year , we identified @number@ incident cases of CVD.
RESULTS : After a mean follow-up of @number@ years , @percent@ of the sample was classified as frail and @percent@ as prefrail.
RESULTS : After a median follow-up of @number@ to @number@ years across cohorts , @number@ cancer cases were identified.
RESULTS : After a median of @number@ months , nutritional parameters ( MNA-SF and BMI ) remained unchanged in both groups.
RESULTS : After clinical use , surface roughness increased considerably.
RESULTS : After contrast agent injection , all PVSAs were not enhanced in the arterial phase ( starting 8-22 s ) .
RESULTS : After controlling for demographic and clinical factors , all volumetric measurements were positively associated with processing speed.
Results : After controlling for sociodemographics and self-rated health , social activity engagement and positive social support were positively related to SOC and its components.
RESULTS : After controlling for the effects of demographic and health-related variables , both acculturation and social activity were identified as significant predictors.
RESULTS : After crossing-cleaning the reference lists , a total of @number@ studies dealing with immune system and menopause were identified.
RESULTS : After excluding participants with eye disease , data from @number@ participants were available for analysis.
RESULTS : After excluding those with impaired cognitive function , @number@ individuals out of @number@ reported a stroke.
RESULTS : After exclusions , @number@ CTC studies were included.
RESULTS : After initial treatment , patients experienced greater pain and displayed increased erythema and swelling in the needle-treated side.
RESULTS : After @number@ h irradiation , 1BR3G human skin fibroblasts were observed to proliferate at a fast rate.
RESULTS : After @number@ months of insulin therapy , mean body weight had increased by @number@ ± @number@ kg ( P < @number@ ) .
Results after @number@ months were similar to those assessed @number@ months before.
RESULTS : After @number@ person-years of follow-up , we observed @number@ HF hospitalization events.
RESULTS : After @number@ years in all specimens , changes of degradation of the filler material could be detected.
RESULTS : After @number@ years , @number@ participants completed all the measurements.
RESULTS : After @number@ years of follow-up , @number@ cases of stroke occurred.
RESULTS : After @number@ years of treatment and follow-up , @number@ incident cataracts were confirmed.
RESULTS : After propensity score matching , @number@ subjects with EOAD and @number@ subjects with LOAD were selected for further analysis.
RESULTS : After randomization , @number@ subjects were assigned to a LGIMD and @number@ to a control diet.
RESULTS : After red-light-PDT , IPL-PDT and IPL treatment , the appearance of photoaging lesion was improved.
RESULTS : After removal of duplicates , our initial search returned @number@ records.
RESULTS : After SOC entry activation , cytosolic Ca ( 2 + ) levels were increased , as expected in all hepatocellular carcinoma cells.
RESULTS : After stent placement , all patients had total incontinence and were catheter-free.
RESULTS : After surgery the time of gait speed test and up and go test was significant longer in comparison to preoperative value.
RESULTS : After the first excise tax increase , no beneficial effects were noted on the outcomes of interest.
RESULTS : After the five-week interventions , the HT group exhibited a larger improvement in aerobic capacity than the NT group.
RESULTS : After the intervention , the experimental group had better physical fitness and life satisfaction when compared with the control group.
RESULTS : After the intervention , the RCG improved and the CG declined.
RESULTS : After therapy , the symptoms and signs of urogenital atrophy significantly improved in both groups.
RESULTS : After the surgeries , both retinas were reattached.
RESULTS : After three cycles of therapy , all patients had resolution of the menometrorrhagia and resumption of ovulatory cycles.
RESULTS : After treatment , patients reported significant reductions on Voice Handicap Index scores , phonatory effort levels , and voice disorder severity.
RESULTS : AF was recorded in @number@ patients ( @number@ % ) .
RESULTS : Age-adjusted AMH levels were @percent@ lower in women with undetectable viraemia and @percent@ lower in detectable viraemia , relative to uninfected women.
RESULTS : Age affected all outcome measures.
RESULTS : Age and APOE showed significant differences among the groups , while sex and lipid profile did not.
RESULTS : Age- and sex-stratified reference values for functional outcome measures were generated.
RESULTS : Age and site had a significant effect on roughness.
RESULTS : Age at birth of the last child was significantly associated with leukocyte telomere length.
RESULTS : Age at first birth exhibited a significant association with BMI.
RESULTS : Age criteria vary , with upper limits recently liberalized in several countries.
RESULTS : Aged care staff focused primarily on health outcomes and identified and addressed several previously undiagnosed conditions.
RESULTS : Aged MSCs displayed senescent features when compared with cells isolated from young donors , concomitant with reduced viability and proliferation.
RESULTS : Aged RPE cells had more lysosome-associated mTOR and had increased response to amino acid stimulation.
RESULTS : Age , functional limitation , the experience of discrimination , and self-esteem independently account for variation in perceived stigma.
RESULTS : Age had a significant effect on the number of cycles leading to embryo transfer ( p < @number@ ) .
RESULTS : Ageing had a negative impact on SRH , but the total effect of age decreased from @number@ to @number@
RESULTS : Ageing-related stereotypic beliefs significantly predicted self-efficacy and health-promoting behaviours.
RESULTS : Ageism was associated with reduced compassion toward the figures.
RESULTS : A gender difference in the type of factors associated with grip strength performance and development across the adult lifespan was found.
RESULTS : A gender-specific approach profile was observed.
RESULTS : A generalized estimating equation was used to model the MMSE scores over time ( mean follow-up @number@.9±2.0 y ) .
RESULTS : Age of the patients in the LA group was significantly higher than that in the control group ( P < 0.001 ) .
RESULTS : Age-related changes occur in all ocular tissues.
RESULTS : Age-related differences in kinematic postural responses were greater during LONG compared to SHORT translations.
RESULTS : Age-related differences in the magnitude of inhibition effects were largest in restraint , followed by deletion.
RESULTS : Age-related larger ITC was found for theta oscillations in the N2-P3 time range during NoGo , only.
RESULTS : Age-stereotype negativity was resilient despite encountering stressful events.
RESULTS : Age subgroups of EAA patients did not significantly differ in lung functions.
RESULTS : Age was associated with decreases in bodyweight , height , total lean mass and bone mass , but an increase in fat mass.
RESULTS : Age was discussed by @percent@ of the @number@ participants.
RESULTS : Age was negatively associated with social engagement actives for Chinese older adults.
RESULTS : Age was not a significant covariate for GE but meal type was.
RESULTS : Age was positively associated with initial social support but negatively associated with the rate of change in social support.
RESULTS : Age was significantly correlated with spine and neck BMD.
RESULTS : Age was similar in [ LLF & LLM ] and [ SLF & / or SLM ] .
RESULTS : Aging conditions and adhesives significantly affected μTBS ( p < @number@ ) .
RESULTS : Aging results in increased peripheral immune responses , impaired peripheral-CNS immune communication , and a shift of the CNS into a pro-inflammatory state.
RESULTS : A great reliability was seen when used for the male volunteers.
RESULTS : AHF was diagnosed in @number@ ( @percent@ ) patients ( age 81±6 years , @number@ men , @number@ women ) .
RESULTS : A high ACL within the HC group was associated with significantly slower response speeds for the Stroop color and incongruent trials.
RESULTS : A high degree of VE was associated with an increased risk of developing type @number@ diabetes in both substudies.
RESULTS : A higher level of serum fetuin-A was well associated with a variety of metabolic disorders and an increased prevalence of MetS.
RESULTS : A higher percentage of blacks than whites were depressed at nearly all time points.
RESULTS : A higher prevalence of psychological distress was observed in older women than in older men.
RESULTS : A higher proportion of Norwegians used PHC services compared to immigrants.
RESULTS : A higher proportion of postchallenge hyperglycemia ( PH ) , both in prediabetes and in diabetes stage , was associated with older age.
RESULTS : A history of colonoscopy was associated with a reduced subsequent risk of CRC , independently of the indication for the examination.
RESULTS : A history of hypertension diagnosis predicted lower cognition.
RESULTS : A history of sleep apnea was associated with shorter LTL ( P = .010 ) .
RESULTS : Airflow limitation prevalence was @percent@ ( male @percent@ and female @percent@ ) and was strongly related to male gender and smoking status.
RESULTS : A larger Stroop effect in errors was associated with reduced rs-fcMRI within the DMN and SAL.
RESULTS : A large wrinkle was observed as dermal buckling following a number of buckling events on the stratum corneum.
RESULTS : Albumin levels and variability showed distinctive changes during each of the @number@ periods.
RESULTS : Alcohol or substance abuse was reported by over @percent@ of respondents , with @percent@ of respondents engaged in maladaptive alcohol use.
RESULTS : A linear k-space trajectory was superior in vitro to centric and centric-paired trajectories.
RESULTS : Alirocumab reduced ultracentrifugally isolated LDL-C by @percent@ , LDL-apoB by @percent@ , and plasma Lp ( a ) by @percent@.
RESULTS : All analyses were conducted separately by sex.
RESULTS : All assessments showed significant skin rejuvenation.
RESULTS : All but the nasal quadrant cpRNFL thicknesses and GCC thicknesses obtained using the @date@ instruments were significantly correlated with age.
RESULTS : All cases were followed up for 12-18 months , mean @number@ months.
RESULTS : All chronic conditions except hypertension were statistically associated with poor results in quality of life and disability.
RESULTS : All cohorts differed significantly from one another , with recent cohorts always obtaining the highest mean HDL-depression score.
RESULTS : All dietary intake and patient characteristic variables showed large individual differences ( ranges ) .
RESULTS : All doses of RT002 were well-tolerated.
RESULTS : All error types increased with chronological age.
RESULTS : All examined aortic wall segments exhibited considerable heterogenous in-plane strain distributions.
RESULTS : All examined groups / sectors were judged to have high risk for occupationally related health problems by over @percent@ of the responders.
RESULTS : All formulas were strongly and independently associated with CVM.
RESULTS : All four network efficiency measures correlated negatively with age.
RESULTS : All genes were upregulated after @number@ h of treatment.
RESULTS : All HAs contained oxygen , carbon , and sodium , but with uneven distributions.
RESULTS : All indexes were significantly and differently associated with PTSD ; associations with depression were non-significant.
RESULTS : All infants experienced NTD.
RESULTS : All instruments showed clear relationships with PGC , with WHODAS-II and DUSOCS performing well ( ANOVA p < 0.001 ) .
RESULTS : All IPS measures showed a significant value to differentiate NCD patients from healthy subjects.
RESULTS : All measures revealed reliable differences between the oldest and youngest participant groups.
RESULTS : All measures were higher in the male than in the female subjects ( P < @number@ ) .
RESULTS : All model-fitted structural , covariate , and statistical parameters were estimated with good to excellent precision ( %RSE ) .
RESULTS : All @number@ flaps survived and got primary healing.
RESULTS : All @number@ midfacial angles in females and glabellar and maxillary angles in males showed statistically significant decreases with aging.
RESULTS : All @number@ participants completed the evaluation.
RESULTS : All @number@ patients completed more than a 6-month postoperative follow-up , and all the patients gained complete recovery.
RESULTS : All @number@ patients experienced reduction or complete resolution , the latter increasing with repeated treatments.
RESULTS : All @number@ patients were Chinese females , @number@ of whom received laser toning for non-ablative skin rejuvenation and the other @number@ for melasma.
RESULTS : All @number@ predictors were associated with well-being at baseline ( P < .05 ) .
RESULTS : All @number@ reserve measures were associated with baseline cognitive function ; the strongest associations were with occupation and the weakest with height.
RESULTS : All @number@ subjects , aged 39-55 years , completed the study.
RESULTS : All @number@ subjects completed the study.
RESULTS : All @number@ subjects completed treatment and received the follow-up examinations at @number@ and @number@ days.
RESULTS : All @number@ subjects enrolled in the study were evaluable for tolerability and @number@ were included in the pharmacokinetic analysis.
RESULTS : All of our patients showed improvement , with an overall patient satisfaction score of @number@
RESULTS : All outcomes showed improvement at @number@ weeks.
RESULTS : All papers reviewed showed that mean total costs increase with disease severity regardless of severity-measurement method.
RESULTS : All participants completed the study.
RESULTS : All participants , comprising @number@ males ( @percent@ ) and @number@ females ( @percent@ ) , were @number@ ( 67-73 ) years old.
RESULTS : All participants indicated a need for nutrition education and cooking programs for this population.
RESULTS : All patients had a median age ( range ) of @number@ ( 19-72 ) years , and @number@ ( @percent@ ) were men.
RESULTS : All patients had improved on the basis of photographic and clinical assessments at @number@ months.
RESULTS : All patients healed uneventfully without any major postoperative problems.
RESULTS : All patients received surgical treatment and there was no perioperative death.
RESULTS : All patients reported a high degree of satisfaction.
RESULTS : All patients tolerated the procedure well.
RESULTS : All patients were extremely satisfied with their treatments.
RESULTS : All patients were followed up from @number@ to @number@ months with an average of @number@ months.
RESULTS : All patients were more than @number@ years old and had been admitted to the hospital for a variety of diagnoses.
RESULTS : All PHP-Ib patients displayed hypocalcemic symptoms.
RESULTS : All physical performance measures significantly decreased with aging.
RESULTS : All predialysis HRV measurements had no differences between stroke patients and those without stroke , but were lower than healthy controls.
RESULTS : All refractive components approximately doubled in prevalence of anisometropia.
RESULTS : All related AEs were mild or moderate and of limited duration.
RESULTS : All samples subjected to TCML survived without mechanical failure.
RESULTS : All skin biopsies from smokers and non-smokers showed cytoplasmic staining in epidermal cells.
RESULTS : All specimens except one survived the artificial aging.
RESULTS : All studied tissues present signs of inflammation during ageing , but with different pattern and intensity.
Results • All studies discussed revealed significant physiological or clinical outcomes as a result of grounding.
RESULTS : All studies showed a statistically significant lengthening of the aging upper lip.
RESULTS : All study subjects had at least one symptom related to psychiatric morbidity.
RESULTS : All subjects showed basic APA patterns in the beginning , such as posterior shift of COP and tibialis anterior firing first.
RESULTS : All tested composite resins showed increase color change after a period of @number@ @number@ and @number@ days.
RESULTS : All texture parameters were significantly associated with the Beagley-Gibson score.
RESULTS : All the dental restorative resin based composites used in this investigation displayed different cyclic wear patterns after undergoing mechanical loading.
RESULTS : All the gelatinase components normally present in control samples were also present in AMD tissue without any significant differences in their molecular masses.
RESULTS : All the @number@ patients had smoking history.
RESULTS : All the participants had normal biochemical results.
RESULTS : All the patients , followed up from @number@ months to @number@ years , were satisfied with the aesthetic results.
RESULTS : All the PQAS-containing cements showed a significant antibacterial activity , accompanying with an initial CS reduction.
RESULTS : All the Δt methods provided a high reproducibility of arch-PWV.
RESULTS : All three interventions resulted in significant improvement in cognitive function as measured by the computerized cognitive assessment.
RESULTS : All three polymorphisms in the ARMS2 / HTRA1 region were in almost complete linkage disequilibrium.
RESULTS : All trajectory models yielded similar results.
RESULTS : All treatments resulted in significant improvements from baseline at all end points and on all PRO measures.
RESULTS : All volunteers showed notable to significant improvement in the photoageing symptoms , without any significant complications or adverse events.
RESULTS : All warts had one or more underlying lymphangiectases compared with @percent@ of peritumor normal skin samples and @percent@ of cosmetic specimens.
RESULTS : aLM index was not significantly different between age groups , but a significantly smaller site-specific MTH thigh ratio was found in the OG.
RESULTS : Almost all AD patients , and most subjects with MCI misidentified landmarks and made navigational errors when following the route without assistance.
RESULTS : Almost all caregivers were spouses or children ( in-law ) .
RESULTS : Almost all mimic muscles , but not the temporalis muscles , had symmetric size.
RESULTS : Almost all the respondents evaluated all the parameters , including the contextual factors , as ' very important'.
RESULTS : Almost half experienced a loss of weight during the follow-up period.
RESULTS : Almost one fifth of the employees admitted that they feel discriminated against in their company.
RESULTS : Almost @percent@ of the total Dutch population and @percent@ of patients @number@ years and older had @number@ or more chronic diseases.
RESULTS : Almost three quarters of community-dwelling older Americans live in a residence that has stairs at the entrance.
RESULTS : Almost two-thirds of individuals with spinal pain did not report any consequence.
RESULTS : Alopecia began at @number@ ± @number@ months and was sustained until @number@ ± @number@ months after chemotherapy initiation.
Results also demonstrated that structural brain networks exhibited a modular organization in which the connections between regions are much denser within modules than between them.
Results also emphasize the importance of age in symptom severity and impact.
Results also failed to support the notion of youthful conceptions having stronger health consequences for Baby Boomers.
Results also revealed increased activity in the right dorsolateral prefrontal cortex in aMCI patients , which may reflect compensation for reduced activations elsewhere.
Results also showed APOE4 / diabetes risk interactions for WM underlying supramarginal , superior temporal , precuneus , superior parietal , and superior frontal regions.
Results also showed that the traditional culture dictated care arrangement.
Results also show gender difference in social support.
Results also show that agitation / aggression tracks declines in cognition and independence independently over time.
Results also suggest a strong relationship between temporal processing and speech understanding in certain competing speech situations.
Results also suggest that high muscle quality may compensate for low ASMI with respect to functional impairments.
Results also suggest that the primary effects of controlling for whole brain integrity were on g associations , not specific abilities.
RESULTS : Although assessment is crucial to a policy pursuing a good quality of life , literature reveals that it is seldom performed.
RESULTS : Although multiple treatment options exist , there are advantages and disadvantages for each.
RESULTS : Although positive outcomes were achieved in all @number@ studies , none of the studies used a control group and randomization process.
RESULTS : Although some specific measures for financial abilities have been developed recently , the same is not true for testamentary capacity.
RESULTS : Although the association of olfactory impairment and malnutrition is widely accepted strong evidence is scarce.
RESULTS : Although the effect of aggregate health expenditure is not conclusive , public health expenditure plays a significant role in enhancing longevity.
RESULTS : Although the HIV-related mortality rate exceeded that from liver-related conditions before @number@ liver disease subsequently surpassed HIV as a cause of death.
RESULTS : Although the inclusion of the antioxidants negatively affected the μTBS over @number@ h , the antioxidant-doped adhesives maintained ( SB-Vit.
RESULTS : Although the majority of GPs indicated lack of competence in diagnosing dementia , only a small percentage showed a preference towards specialist referral.
RESULTS : Although triage accuracy has improved from @number@ to @number@ the undertriage rate still remains higher than the ACS-COT target of 5-10%.
RESULTS : Although visits to physicians and specialists were frequent , visits to dentists were lower in both populations.
RESULTS : Although younger and older adults differed in task-related activation , they showed comparable reward-related activation.
RESULTS : Altogether , @number@ consecutive LRs were performed in @number@ patients ( mean age @number@ ± @number@ years ) .
RESULTS : Altogether , @number@ participants completed the study in the first @number@ weeks.
RESULTS : Altogether @number@ persons ( @number@ men , @number@ women ; median age : @number@ years ) were included.
RESULTS : Altogether , @number@ subjects completed the study course and follow-up visits.
RESULTS : Altogether , @percent@ ( n = @number@ ) of the participants had restricted life-space ( LSA score < @number@ ) .
RESULTS : Altogether @percent@ participants developed stroke.
RESULTS : A majority ( @number@ % ) of injurious falls caused serious injuries such as fractures and open wounds.
RESULTS : A majority of nondrivers relied on their informal support system and / or paid assistance to drive them to places.
RESULTS : A majority of participants ( @percent@ ) reported occupational exposures to loud noise and / or ototoxic chemicals.
RESULTS : A majority ( @percent@ ) of participants recognized the POLST form.
RESULTS : Ambient air concentrations of particulate matter with aerodynamic size < @number@ microm ( PM10 ) declined in average by @number@ microg / m3.
RESULTS : aMCI subjects with high SSL scores presented higher cortisol levels ( p = @number@ ) .
RESULTS : AMD was observed in @percent@ out of @number@ subjects of @number@ years and above age group with prevalence increasing with age.
RESULTS : A mean follow-up of @number@ years after the second height measurement gave rise to @number@ CHD events in men and @number@ in women.
RESULTS : A mild to marked hyperpigmentation was observed and remained for a variable period.
RESULTS : A model of the process of spread of best practices within home care organizations was developed.
RESULTS : Among 1723 / 1762 women included in the final analysis , hrHPV and HPV16 / 18 prevalence was @number@ and @percent@ , respectively.
RESULTS : Among all participants , dementia was diagnosed in @number@ subjects , and @number@ persons had questionable dementia.
RESULTS : Among all participants , @number@ ( @percent@ ) experienced cognitive decline during the study period.
RESULTS : Among APOE-e4 carriers , there was no significant difference in depressive symptoms between high active and low active groups.
RESULTS : Among both men and women , older age was associated with self-reported impairment of vision , hearing , and pleasantness of light touch.
RESULTS : Among four miRNAs , only levels of miR-196a2 were significantly decreased from BD patients with active ileocecal ulcers as compared with healthy controls.
RESULTS : Among HIV-infected patients ( n = @number@ @number@ ) , @percent@ received at least one acetaminophen prescription.
RESULTS : Among @number@ adults ( mean age @number@ @percent@ men , @percent@ black ) , @number@ ( @percent@ ) developed diabetes over @number@ years.
RESULTS : Among @number@ cases of supratentorial ICH with volumes < 30 mL , expansion and END rates were @percent@ and @percent@ , respectively.
RESULTS : Among @number@ CN individuals , @number@ ( @percent@ ) self-reported a head trauma.
RESULTS : Among @number@ common diagnoses , only sleeping problems , urinary incontinence and stroke were significantly related to life satisfaction.
Results : Among @number@ components of successful aging , those related to self-sufficiency received the highest acknowledgment among the elderly individuals in Singapore.
RESULTS : Among @number@ deaths , we found significantly higher mortality for twin boys than for twin girls.
RESULTS : Among @number@ elderly patients , the mean age was @number@ ( 75-99 ) years.
RESULTS : Among @number@ elderly patients with lung cancer , @number@ cases occurred perioperative arrhythmias.
RESULTS : Among @number@ HIV-infected patients , @percent@ reported having a history of incarceration.
RESULTS : Among @number@ individuals , @number@ people ( @percent@ ) died of CHD during @number@ person-years of follow-up.
RESULTS : Among @number@ @number@ baseline participants , @number@ @number@ ( @percent@ ) attended the follow-up examination.
RESULTS : Among @number@ @number@ patients surviving > 30 days , 1-year mortality was @percent@.
RESULTS : among @number@ nursing home decedents , @percent@ ( n = @number@ ) died in hospitals.
RESULTS : Among @number@ old people ( average age @number@.6±8.4 years old ) , @number@ residents suffered from xerostomia ( @percent@ ) .
RESULTS : Among @number@ participants aged ≥60 , @number@ ( @percent@ ) were men.
RESULTS : Among @number@ participants ( @percent@ men , mean age @number@ years ) there were @number@ adverse cardiovascular events.
RESULTS : among @number@ participants , @percent@ ( @percent@ CI = 76-79% ) were overweight or obese ( n = @number@ ) .
RESULTS : Among @number@ participants , the 5-year incidence of functional disability was @percent@.
RESULTS : Among @number@ participants , the mean age was @number@ ( SD = 9.2 ) and @number@ ( @percent@ ) were African American.
RESULTS : Among @number@ patients analyzed , @percent@ of the patients were adherent.
RESULTS : Among @number@ patients diagnosed with CeAD , we identified @number@ patients ( @percent@ ) aged ≥60 years.
RESULTS : Among @number@ patients , @number@ ( @percent@ ) developed incident delirium.
RESULTS : Among @number@ patients , we excluded @number@ patients from the waiting list including @number@ ( @percent@ ) who displayed malignancies.
RESULTS : Among @number@ patients with MCA-M1 occlusions who received IV tPA , @number@ were treated according to the protocol of sequential combined IV thrombolytics.
RESULTS : Among @number@ postmenopausal women , @number@ women were classified as normal , @number@ as osteopenic and @number@ as osteoporotic.
RESULTS : Among @number@ tested subjects , the 99th percentile for all samples was @number@ ng / l.
RESULTS : Among older adults , @percent@ was found to be underweight , @percent@ normal weight , @percent@ overweight , and @percent@ obese.
RESULTS : Among older adults , @percent@ were fully able to complete self-care and mobility activities.
RESULTS : Among older adults with diabetes of short duration , cardiovascular complications followed by hypoglycemia were the most common nonfatal complications.
RESULTS : Among our study cohort , the mean years of follow-up were @number@ for ROS and @number@ for MAP.
RESULTS : Among participants , @percent@ were premenopausal , @percent@ were perimenopausal , and @percent@ were postmenopausal.
RESULTS : Among six differentially expressed protein spots , ceruloplasmin ( Cp ) and fibrinogen were over-expressed in obese group.
RESULTS : Amongst @number@ patients , @number@ patients ( @percent@ ) had cancer , of whom @percent@ were in remission.
RESULTS : Among the available drugs , @number@ ( @percent@ ) were included within the Beers-Fick criteria.
RESULTS : Among the evaluable subjects , @number@ ( @percent@ ) demonstrated aesthetic improvement at @number@ days based on blinded assessments.
RESULTS : Among the frail ( @percent@ ) , @percent@ had both depressive symptoms and anemia and @percent@ had pulmonary disease and anemia.
RESULTS : Among the @number@ blood samples , @number@ samples were confirmed to be infected with malaria by microscopic examination.
RESULTS : Among the @number@ included patients ( @number@ women and @number@ men ) , @percent@ displayed poly-pathologies.
RESULTS : Among the @number@ mtSNPs with minor genotype frequencies > 0.05 , @number@ mtSNPs were associated with coronary atherosclerosis.
RESULTS : Among the @number@ @number@ subjects , the median of MMSE sore was @number@
RESULTS : Among the @number@ participants , @number@ died during the follow-up period ( 1996-2004 ) .
RESULTS : Among the @number@ patients evaluated during the study period , @number@ ( @percent@ ) presented with mild memory complaints.
Results : Among the @number@ patients included , mean age at presentation was @number@ years.
RESULTS : Among the @number@ patients included , @number@ were assessable at @number@ months.
RESULTS : Among the @number@ patients , @number@ were male and @number@ were female , aging 43-61 years.
RESULTS : Among the @number@ patients , the mean age was 68±6.02 years , and @percent@ had MDD.
RESULTS : Among the @number@ patients who were diagnosed as fallers , eight became non-fallers.
RESULTS : Among the @number@ patients with thyroid cancer , the overall prevalence of tracheal invasion was @number@.4-0.7%.
RESULTS : Among the @number@ SNPs , rs2222823 and rs2811712 were found to be significantly associated with CSVD after multiple-testing adjustment.
RESULTS : Among the @number@ subjects enrolled , @percent@ were female and @percent@ were African American.
RESULTS : among the @number@ veterans who were dispensed medicines for diabetes , @percent@ had five or more co-morbidities.
RESULTS : Among the @number@ women studied , @number@ ( @percent@ ) were aged @number@ or more.
RESULTS : Among the participants ( n = 167 ) , @percent@ had at least one vascular risk factor.
RESULTS : Among the participants , the prevalence of the metabolic syndrome was 37·0%.
RESULTS : Among the patients included , @percent@ had an EUR and @percent@ of their caregivers reported a high level of burden.
RESULTS : Among the selected home-visit nursing agencies , responses suitable for analysis were obtained from @number@ ( effective response rate , @percent@ ) .
RESULTS : Among these @number@ participants , @number@ had dementia and @number@ had possible or probable AD.
RESULTS : Among the study group , @number@ women were not sexually active both at the time of surgery and during the follow-up period.
RESULTS : Among the total of @number@ HPVG patients , the overall mortality rate was @percent@.
RESULTS : Among those aged 20-29 , E ' was significantly higher in female than in male.
RESULTS : Among those who received intensive chemotherapy , there were @number@ cases of remission after induction chemotherapy ; treatment-related mortality was @percent@.
RESULTS : Amplitude and latency of M1 and M2 peaks did not change significantly from before to after surgery.
RESULTS : Amplitudes of the Novelty P3 and a late positive potential ( LPP ) were significantly larger in younger compared to older participants.
RESULTS : A multiple regression analysis found chronological age , intelligence , and SES to be predictive of performance on the SOPT.
RESULTS : An 87-item QI set was accepted by the expert panel.
RESULTS : An abnormal test occurred in @percent@ of NC , @percent@ of MCI , @percent@ of FTD , and @percent@ of AD subjects.
RESULTS : Analyses revealed age-related linear and quadratic volumetric change in the amygdalae and hippocampi , respectively.
RESULTS : Analyses revealed evidence for direct and independent multidirectional accounts.
RESULTS : Analyses revealed good content validity , factorial validity , internal consistency reliability , and construct validity in terms of expected theoretical group differences.
RESULTS : Analyses showed that EF measures were predictive of adaptive abilities , and significant interactions between D-KEFS measures and group were present.
RESULTS : Analyses suggest limited evidence that the receipt of help is a supply-driven phenomenon.
RESULTS : Analyses were performed on the @number@ workers in the intervention and @number@ workers from the business as usual group.
RESULTS : Analysis of data from the @number@ medical charts showed that @number@ patients ( @percent@ ) presented with AF.
RESULTS : Analysis of data on erythrocyte ageing patterns revealed that @number@ separate RBC turnover mechanisms seem to be present.
RESULTS : Analysis of mRNAs demonstrated a decrease in Tie1 expression in CVDRF individuals compared with aged or young healthy individuals.
RESULTS : Analysis of variance showed a significant difference between the study and control groups ( P = @number@ ) .
RESULTS : Analysis showed a significant increase in older patients between @number@ and @number@ ( p < @number@ ) .
RESULTS : A national estimate of @number@ PHF discharges was identified over the time period.
RESULTS : Anatomical features , and in particular vascularization , expose PTT to major degenerative disorders until rupture.
RESULTS : Anchor-based MICs of the Katz-ADL index score were @number@ points , while distributional MICs ranged from @number@ to @number@ points.
RESULTS AND CONCLUSION : Complications following homogenous hydrogels are caused by infection with bacteria , which have been inserted into the gel during injection.
RESULTS AND CONCLUSION : NLV used in regime S extended the life of patients , in particular , patients with spinal onset.
RESULTS AND CONCLUSION : One hundred twenty-six ( @percent@ ) participants had diabetes.
RESULTS AND CONCLUSION : Results showed that age was significantly associated with positive emotions and cognitive reappraisal.
RESULTS AND CONCLUSIONS : Baseline carotid artery compliance and brachial artery FMD were lower in postmenopausal than premenopausal women ( P < @number@ ) .
RESULTS AND CONCLUSIONS : During follow-up years from @number@ to @number@ @number@ participants developed acute CVD events and @number@ died.
RESULTS AND CONCLUSIONS : From @date@ to @date@ , @number@ individuals attended HEALE curriculum sessions at @number@ locations in Chicago and surrounding areas.
RESULTS AND CONCLUSIONS : The combined reproductive technologies yielded @number@ carriers and @number@ affected animals.
RESULTS AND CONCLUSIONS : The dominant GM fraction of DS persons showed an overall mutualistic immune-modulatory layout , comparable to that of healthy controls.
RESULTS AND CONCLUSION : The length of telomeres in cells of buccal epithelium was shorter in patients with PD than in the control group.
RESULTS AND CONCLUSION : The mean score of respondents ' SOC was @number@ ( SD = @time@ ) .
RESULTS AND CONCLUSION : The results revealed a significant cognitive decline in the fluid and crystal intelligence depending on age.
RESULTS AND DISCUSSION : Healthy male controls and opiate-dependent male patients were studied on @number@ and @number@ occasions , respectively.
RESULTS AND DISCUSSION : The demographic characteristics of the participants in the pre- and post-intervention groups were similar.
RESULTS AND DISCUSSION : This article shows a variety of concepts that have been developed to support elderly people in their ADLs.
RESULTS AND DISCUSSION : We present current therapeutic approaches focused on intermittent parathyroid hormone and Wnt signaling agonists / antagonists.
RESULTS AND IMPLICATIONS : No single symptom seemed sufficient to alert participants that dementia might be present.
RESULTS AND LIMITATIONS : After an expected initial decline , time-dependent improvements in SF and EF were observed through @number@ yr postoperatively.
RESULTS AND LIMITATIONS : The mean age ( SD ) of the group was @number@ ± @number@ years.
RESULTS : Androgen deprivation therapy recipients reported increasing hot flash interference with time relative to controls ( p < 0.001 ) .
RESULTS : Anemia was found in @percent@ of subjects studied.
RESULTS : Anemia was identified in @number@ ( @percent@ ) of the cohort.
RESULTS : An epigenome-wide discovery revealed two CpG sites in the promoter region of KIAA1549L that were significantly differentially methylated between cases and controls.
RESULTS : An estimated @number@ million community-dwelling older Americans may have dementia , and approximately @number@ million may have substantial depressive symptoms.
RESULTS : An expected linear increase with age was observed for hypertension , hyperlipidemia , obesity , and vascular compliance measured by pulse pressure.
RESULTS : Animal experiments showed that EVOO significantly increased BMD and decreased phosphatase , alkaline phosphatase , IL-6 , MDA , and nitrate levels.
RESULTS : An increase of the expression of structural proteins and inflammatory markers could be observed in MRI-groups @number@ and @number@
RESULTS : An intensive dietary and behavioral intervention was developed to achieve @percent@ CR and sustain it over the @number@ years.
RESULTS : An involvement of caspase-3 / keratin-18 pathway and serine / threonine kinase Aurora A / MDM2 pathway was shared between RS and SIPS.
RESULTS : Annual incidences for hospitalizations were @percent@ ( @percent@ CI , @number@ to @number@ ) .
RESULTS : Antagonism was associated with an increased risk of smoking.
RESULTS : Antecubital fossa veins are associated with lower phlebitis rates , while hands veins are the most risky sites to develop phlebitis.
RESULTS : Anthracycline regimens were used by @percent@ of women treated on-trial vs. @percent@ of those treated off-trial.
RESULTS : Anthropometric , clinical and biochemical data revealed an elevated prevalence of classic cardiovascular risk factors in the sample.
RESULTS : A @number@ year-old male patient was admitted to the hospital because of chest pain on the left side for @number@ month.
RESULTS : Anxiety and depressive symptoms were related significantly ( p < @number@ ) to six of the seven CRA self-esteem items.
RESULTS : AOx alone did not reduce erythema.
RESULTS : Apart from DHT , an age-dependent change of sex hormone levels were observed.
RESULTS : A @percent@ ( weight / volume ) supplement of AR or RS affected life-history and other physiological traits in distinct ways.
RESULTS : APN , AdipoR1 , and AdipoR2 were identified in the neural retina and in the RPE-choroid of humans and mice.
RESULTS : ApoE ε2 and ε4 was present in @percent@ and @percent@ , respectively , and postoperative delirium occurred in @percent@.
RESULTS : APOE ε3ε4 and ε4ε4 genotypes increased AD risk with dosage effect.
RESULTS : APOE ε4 allele frequency was @percent@.
RESULTS : Appalachia and the Mississippi Delta had higher levels of tooth loss than the rest of the country in @number@
RESULTS : Appendicular muscle mass and knee extension strength decreased with age in both men and women.
RESULTS : Application of a ceramic primer did not result in a negative impact on SBS.
RESULTS : Application of the concurrent Brooks ' Spatial Memory task led to longer step times compared to the baseline condition.
RESULTS : Application of the implant exhibited a lowering effect on IOP.
RESULTS : approximately a third ( @percent@ ) of all respondents experienced age discrimination , rising to @percent@ in those aged @number@ and over.
RESULTS : Approximately half the residents were well nourished with @percent@ moderately or severely malnourished.
RESULTS : Approximately one in four deaths were attributable to cardiovascular and one in six to neuropsychiatric diseases.
RESULTS : Approximately one in four pre-seniors and seniors reported at least one OHRQoL impact ' fairly / very often'.
RESULTS : Approximately one in three participants utilized bereavement services.
RESULTS : Approximately @percent@ ( 1062 / 2140 ) of participants took DS.
RESULTS : Approximately @percent@ and @percent@ of older Mexican adults were either overweight or obese , respectively.
RESULTS : Approximately @percent@ of older drivers reported having fallen two or more times in the prior year.
RESULTS : Approximately , @percent@ of older volunteers kept volunteering and @percent@ stopped or started their volunteering over time.
RESULTS : Approximately @percent@ of participants initiated smoking cessation treatment during the 2-month follow-up.
RESULTS : Approximately @percent@ of participants reported ExH , and @percent@ reported ExQoL.
RESULTS : Approximately @percent@ of participants were assessed as being at risk for malnutrition or as being malnourished.
RESULTS : Approximately @percent@ of participants were depressed and @percent@ experienced communication difficulty.
RESULTS : Approximately @percent@ of probes had an ICC > @number@ and were considered stable VMPs ( stable-VMPs ) .
RESULTS : Approximately @percent@ of the men and @percent@ of the women who were normal weight according to BMI had excessive %BF.
RESULTS : Approximately @percent@ of the @number@ participants had experienced early parental loss.
RESULTS : Approximately @percent@ of the participants were at risk for losing physical independence at @number@ years of age.
RESULTS : Approximately @percent@ of the sample was discharged to the community.
RESULTS : Approximately @percent@ of the sample were categorized with elevated depressive symptoms at follow-up ( a score ≥ @number@ on the CES-D ) .
RESULTS : Approximately two-thirds of family caregivers ( N = @number@ ) were involved in one or more medication management activities.
RESULTS : A prior warfarin use was present in @number@ patients ( @percent@ ) .
RESULTS : A progressive increase in both skin extensibility and hysteresis was observed , contrasting with a decrease in biologic elasticity.
RESULTS : A projected increase in distance between entry point and target of 5-10 mm was found from age @number@ to @number@ years.
RESULTS : A prototype system is developed using ADE cases reported over @number@ years and recommendations obtained from decision tree analysis are validated by physicians.
Results : A quarter of the sample were current smokers and @percent@ reported a prior history of smoking.
RESULTS are based on ordinary least squares regression analyses.
Results are compared for young and older control subjects and older adults with AMD to determine the factors underlying performance on this test.
Results are compared to ground truth based on a grading scale from 0-5.
Results are compatible with the notion that bones adapt to exercise-specific forces throughout the human lifespan.
Results are discussed in light of the literature on age-related cognitive decline.
Results are discussed in relation to how memory strategy use can be enhanced to improve everyday memory ability in older adults at risk for dementia.
Results are discussed in relation to the temporal self-appraisal theory.
Results are discussed in relation to this study's value with respect to determining cognitive impairment in individuals free from probable dementia or stroke.
Results are discussed in terms of age-related changes in language processing and context use in bilinguals.
Results are discussed in terms of age-related decline in resilience towards distributed processing while simultaneously preserving the ability to integrate parafoveal information into foveal processing.
Results are discussed in the context of life course perspectives on goal orientations and self-regulatory processes.
Results are discussed in the context of the multiprocess theory of prospective memory.
Results are discussed in the light of age differences in motivation.
Results are discussed within the framework of theories of adolescent behaviour.
Results are discussed with reference to retest effects and clinical implications.
Results are discussed with respect to their implications for intergenerational interaction , and interpreted through the lens of communication accommodation theory.
RESULTS : A reduction of ADC values with ageing was found in the spleen ( r = @number@ p < @number@ ) .
Results are expressed as hazard ratios ( HR ) and their @percent@ CI.
Results are expressed using 10-90 percentiles.
RESULTS : ARE from 126 / 127 tissues and cell-types were significantly enriched for stronger CRC-variant associations.
Results are grouped separately for all ( @number@ ) aging clusters.
Results are inconclusive for endurance outcomes , and no consistent effect was observed on balance and the ADL functional mobility.
Results are informative of the neural correlates of the development of attention networks in childhood.
RESULTS : ARE inhibited the viabilities of several cancer cells , including MDA-MB321 , K562 , HT29 , Hep3B , DLD-1 , and LLC.
Results are interpreted in terms of a spatial aging effect on mental transformations of three-dimensional representations of space in working memory.
RESULTS : A reliable ( ρ = @number@ ) unidimensional construct was established , meeting the Mokken item response theory criteria of medium scalability.
Results are linked to the theoretical location of T2D on an adjusted neural vulnerability continuum.
Results are maintained in women with recurrent prolapse after prior failed reconstructive surgery.
RESULTS : A remarkable expression of SMP-30 was seen in a control pediatric normal liver in comparison with that in an aged adult donor biopsy.
RESULTS : A remarkably lower dissection energy was needed to dissect within the individual ILT layers and through the thicknesses of old thrombi.
Results are most promising for cognitively less fit women.
Results are supportive of the view that retirement is associated with more rapid cognitive aging.
RESULTS : Arguments for and against deceiving patients with dementia overlapped with those previously described in relation to clinical practice in general.
RESULTS : Arm , leg , trunk and total fat masses correlated positively ( r = 0.78-0.95 ) with each other.
RESULTS : A robust association was observed between baseline handgrip strength and 1-year cognitive decline after multiple adjustment.
RESULTS : Arterial calcifications were significantly more common in the PPI group ( p < @number@ ) .
RESULTS : As a result of an exploratory and confirmation factor analysis a one-factor tool with five items was built.
RESULTS : As a result of the scenario process , five consistent scenarios were developed.
RESULTS : ASC induced proliferation of photo-aged HDF and type I collagen production and decreased MMP-1 production and expression of p16.
RESULTS : As compared to the group with psychoeducation and discussion , the group with enhanced BA had decreased levels of depressive symptoms.
RESULTS : As demonstrated by our center's patient demographics and national U.S. data , IVF centers are destined to treat increasingly adversely selected patients.
RESULTS : ASD was effective in reducing A1C and frailty in participants who did and did not use a walking aid.
RESULTS : A search of five databases yielded @number@ documents published between @date@ and @date@ .
RESULTS : As expected , age correlated significantly with concentrations of immune markers and neuropsychiatric symptoms.
RESULTS : As expected , age differences were larger when the text was absent.
RESULTS : As expected CDS score was significantly higher in the patient group compared to the healthy control group.
RESULTS : As expected , CR was related to change in body weight.
RESULTS : As expected , older adults were more biased than young adults.
RESULTS : As expected , older age was associated with less decline in positive affect while engaging with an intrusive thought.
RESULTS : A sheet of connective tissue , comparable to a septum , was consistently found between the lateral-temporal and the middle compartments.
RESULTS : Aside from race and ages below @number@ years , none of the investigated factors had substantial impact on LC.
RESULTS : A significant correlation was identified between RRT parameters and subject age at all three measurement sites.
RESULTS : A significant group by time interaction effect ( P = .02 ) was observed only for the 1RM leg press.
RESULTS : A significant improvement in all scores was observed.
RESULTS : A significant improvement in both subjective and objective evaluations was observed.
RESULTS : A significant interaction was observed between testosterone and APOE genotype ( epsilon4-negative vs epsilon4-positive ) .
RESULTS : A significant inverse relationship was found between baseline CIMT and annual EXEC score , but not annual MEM score.
RESULTS : A significantly higher use of anxiolytics was observed among women compared to men after taking into account their worse physical and mental health.
RESULTS : A significant main effect for duration was obtained.
RESULTS : A significant negative correlation was found between the WAI score and age , years in current job , and number of reported diagnoses.
RESULTS : A significant relationship was found between the density of LTS and the presence of VH in PD , AD , and DLB.
RESULTS : A single advice-seeking network appears to span the nation.
RESULTS : A single relevant pattern emerged that included leg strength and fat mass as predictors of the @number@ physical function variables.
RESULTS : As in older adults , prevalence rates varied widely.
RESULTS : A small percentage ( @percent@ ) of the oldest-old participants reported that they did not feel old.
RESULTS : ASM alternative splicing events occurred significantly less frequently in MDD patients compared to healthy subjects.
RESULTS : As of @date@ , @number@ ( @percent@ ) of @number@ eligible ≥ 10-year survivors have been contacted.
RESULTS : A soft pancreatic parenchyma with a not-dilated duct ( diameter < 3 mm ) was reported in all the @number@ patients.
RESULTS : Aspects of lens shape change relative to stretch were evaluated , including change in diameter , central thickness and accommodation.
RESULTS : AS performance in MCI resembled that in NE ; subjects with AD were impaired relative to both MCI and NE.
RESULTS : As predicted , participants with PTSD had shorter age-adjusted LTL than control subjects.
RESULTS : As regards the healthy sample , we found age-related deterioration in VR task performance.
RESULTS : Assessed care needs have increased regardless of dementia status.
RESULTS : Assessments of 3D photographs revealed an overall improvement in @percent@ of study subjects.
RESULTS : Assessments of SFCT and cataract were available for @number@ subjects.
RESULTS : Associated conditions of intertrochanteric fractures in the elderly are osteoporosis , dementia , cardiac disease and hypertension.
RESULTS : Associations between observed and proxy reports were stronger than between observed and self-report across BADL and IADL measures.
RESULTS : Associations between SEP measures over the life course and cognition were similar across study centers.
RESULTS : Associations were demonstrated between the five NEO-FFI personality traits , and all included demographic factors.
RESULTS : Assuming autosomal recessive inheritance , we identify @number@ genes that have homozygous or compound heterozygous loss-of-function variants in PD cases.
RESULTS : A statistically significant improvement in voiding function was noted postoperatively.
RESULTS : A statistically significant increase of lipid film in both U-zone and T-zone and on the neck was observed in the study group.
RESULTS : A statistically significant reduction of the duration of VA during the intervention phase relative to other phases of the protocol was found.
RESULTS : As the age growing , the response rate for oVEMP decreased.
RESULTS : As the patients aged , the parameters of acetabular dysplasia decreased.
RESULTS : Asthmatic patients showed a statistically significant increase in CD4 + T cells.
RESULTS : A strong correlation between the SBR and age was observed.
RESULTS : A summary of the findings of each article is provided as a table within this introduction.
RESULTS : A survey of literature revealed that the major chemical constituents of Hippocampus are sterides , essential amino acids , fatty acids and microelements.
RESULTS : Asymptomatic participants and those with non-allergic rhinitis alone were mostly non-sensitized ( around @percent@ ) while around @percent@ were polysensitized.
RESULTS : At 2-year follow-up , @percent@ and @percent@ of initially independent persons were ADL dependent in the development and validation samples , respectively.
RESULTS : At 3months , mean GH and in IGF-1 were similar between the three groups.
RESULTS : At 3-year follow-up , @number@ participants had developed dementia.
RESULTS : At 6-month follow-up , @number@ patients resulted asymptomatic : able to maintain standing position and walk without crunches.
RESULTS : At a 15-month follow-up survey , @number@ participants ( @percent@ ) reported the development of depressive symptoms.
RESULTS : At all ages , premutation carriers exhibited lower AMH levels.
RESULTS : At all levels of intensity , elderly individuals with MCI were significantly worse at identifying each EFE than healthy subjects.
RESULTS : At all sites on B-mode , cartilage and tendon thicknesses showed positive or negative correlations with age ( P < @number@ ) .
RESULTS : At a median time of 13months , @number@ out of @number@ analyzable patients ( @percent@ ) developed RILF after treatment.
RESULTS : At baseline , 21 ( @percent@ ) persons had prevalent ESRD.
RESULTS : At baseline and Year @number@ total SM was lower in HIV-infected than control men.
RESULTS : At baseline , approximately @percent@ of study participants reported having COPD.
RESULTS : At baseline , average levels were @number@ nmol / L in the younger cohort and @number@ nmol / L in the older cohort.
RESULTS : At baseline evaluation , @number@ subjects were cognitively normal , and @number@ subjects had MCI.
RESULTS : At baseline , groups did not differ in absolute MAC-Q , NSL or ADAS-Cog scores.
RESULTS : At baseline , LVH was not associated with worse cognitive function.
RESULTS : At baseline , MAs had a higher prevalence of diabetes mellitus and frailty and lower socioeconomic status ( SES ) than EAs.
RESULTS : At baseline , MAs who had recently become caregivers exhibited a significantly greater number of depressive symptoms compared to those who had not.
Results : At baseline , more than @percent@ of participants reported some degree of UI.
RESULTS : At baseline , @number@ GPs examined @number@ patients.
RESULTS : At baseline , @number@ participants had a positive history of VTE.
RESULTS : At baseline , @number@ participants had diabetes , and @number@ of them were using insulin.
RESULTS : At baseline , @number@ participants had no significant baseline group differences in clinical or demographic characteristics.
RESULTS : At baseline , @number@ ( @percent@ ) MCI were FBB + .
RESULTS : At baseline , @number@ ( @percent@ ) men and @number@ ( @percent@ ) women were prefrail.
RESULTS : At baseline , @number@ ( @percent@ ) of the initial @number@ participants had sarcopenia.
RESULTS : At baseline , @number@ ( @percent@ ) patients had a vitamin C concentration below @number@ µmol / L indicating biochemical depletion.
RESULTS : At baseline @number@ ( @percent@ ) patients showed pathological ultrasonographic findings.
RESULTS : At baseline , @percent@ ( n = @number@ ) of men had ED.
RESULTS : At baseline , @percent@ of DAT , @percent@ of MCI , and @percent@ of HC subjects showed high PiB retention.
RESULTS : At baseline , @percent@ of participants reported being discriminated against at least a few times a year.
RESULTS : At baseline , @percent@ of subjects developed day-time hypertension , @percent@ developed night-time hypertension and @percent@ developed 24-hour hypertension.
RESULTS : At baseline , @percent@ of the subjects reported good sleep , with @percent@ reporting a sleep duration of approximately @number@ hr.
RESULTS : At baseline @percent@ reported MC.
RESULTS : At baseline , @percent@ reported weight loss ( mean = @number@ kg , SD = @number@ ) in @number@ months.
RESULTS : At baseline , relatively healthy ( N = @number@ ) and multimorbid ( N = @number@ ) women did not differ in RMR.
RESULTS : At baseline , serum FGF21 levels increased progressively with eGFR category ( P for trend < .001 ) .
RESULTS : At baseline , the average age was @number@ years , @percent@ were female , @percent@ and @percent@ were prefrail and frail , respectively.
RESULTS : At baseline , the frequency of leaving one's home was associated with a decrease in carotenoid levels.
RESULTS : At baseline the median BMI is @number@ ( Interquartile range : @date@ @number@ Kg / m ( @number@ ) ) .
RESULTS : At baseline , the participants showed rather high levels of positive life orientation ( PLO total score @number@ ) .
RESULTS : At baseline , the prevalence of LAE was @percent@.
RESULTS : At baseline , the PTSD group had higher frequencies of comorbid depression and anxiety disorders and worse MHQoL than the other groups.
RESULTS : At baseline , there was a mild negative correlation by age for total lymphocytes and CD3 ( + ) T-cells.
RESULTS : at baseline , there were no significant between-group differences.
RESULTS : At baseline , there were @number@ ( @percent@ ) and @number@ ( @percent@ ) participants aged ≥65 and 18-64 years , respectively.
RESULTS : At both pharyngeal levels , tongue-hold swallows produced lower peak pressure compared with saliva swallows.
RESULTS : At diagnosis , @percent@ were overweight ( BMI = 85-94.9th percentile ) or obese ( BMI ≥ 95th percentile ) .
RESULTS : At discharge , there was no statistical difference in the change of total Modified Barthel Index score between control and intervention groups.
RESULTS : At each wave , frailty was nonlinearly associated with age , with acceleration in later years.
RESULTS : At enrollment , @number@ ( @percent@ ) had CKD.
RESULTS : At equivalent received intensities , the mean ratings were significantly lower in older than in younger subjects.
RESULTS : At first , @number@ studies were included in a meta-analysis.
RESULTS : At follow-up , @percent@ of the sample was defined as healthy ageing.
RESULTS : At follow-up , @percent@ of the surgical group were seizure-free , and @percent@ were no longer taking antiepileptic medication.
RESULTS : At follow-up , their mean age was @number@ ( SD = @number@ ) , of whom @percent@ were females.
RESULTS : A third of patients in each group had a previous fragility fracture.
RESULTS : A three-level classification framework for PCA is described comprising both syndrome- and disease-level descriptions.
RESULTS : At individual level , activities of daily living and income significantly predicted depressive symptoms.
RESULTS : At Landspitali ED , @number@ individuals were assessed , of whom @percent@ were women.
RESULTS : At least @number@ noncompressible ankle artery was observed in @number@ ( @percent@ ) of the @number@ feet.
RESULTS : At least one task of NPA showed provocative effect in @percent@ of cases.
RESULTS : At @number@ h , the shear bond strength values of all groups except the control showed no statistically significant difference.
RESULTS : At @number@ months , the intervention had positive effects on functional difficulty and all mediators ( P < @number@ ) .
RESULTS : At @number@ week , @number@ weeks , and @number@ weeks after treatment initiation , improvements in VAS were significantly greater with PRF.
RESULTS : A total of 44 / 91 subjects were Aβ-positive on PET scan.
RESULTS : A total of eleven articles were included in the review.
RESULTS : A total of @number@ 50-year or older adults were followed-up for eleven years , with a mean age of @number@
RESULTS : A total of @number@ acute ischemic stroke subjects were included in the final analysis.
RESULTS : A total of @number@ ADC papers were published from @number@ through @number@
RESULTS : A total of @number@ adults were identified to have HF in @number@
RESULTS : A total of @number@ articles met the inclusion criteria.
RESULTS : A total of @number@ articles were found.
RESULTS : A total of @number@ articles were identified.
RESULTS : A total of @number@ articles were obtained , but @number@ were included in the analyses.
RESULTS : A total of @number@ articles were retrieved , @number@ full texts were assessed for eligibility , and @number@ articles met the inclusion criteria.
RESULTS : A total of @number@ asymptomatic men were included in this study.
RESULTS : A total of @number@ cancers were identified during 1943-2009.
RESULTS : A total of @number@ cases and @number@ controls were included in the seven studies.
RESULTS : A total of @number@ cases ( @number@ male and @number@ female patients ) were evaluated.
RESULTS : A total of @number@ cases of BP were diagnosed ( in @number@ males and @number@ females ) .
RESULTS : A total of @number@ cases were reported.
Results : A total of @number@ children and adolescents aged 6- to 18-years old were included.
RESULTS : A total of @number@ citations were found.
RESULTS : A total of @number@ clients were present in the facility during the reporting period.
RESULTS : A total of @number@ clinicians from @number@ countries answered to the survey.
RESULTS : A total of @number@ COPD patients were enrolled.
RESULTS : A total of @number@ COP episodes out of @number@ hospital visits were enrolled during the surveillance.
RESULTS : A total of @number@ deaths occurred during @number@ person-years of follow-up.
RESULTS : A total of @number@ DEGs were screened , including @number@ up- and @number@ down-regulated genes.
RESULTS : A total of @number@ discs in these @number@ patients were treated with PCD.
RESULTS : A total of @number@ ECPBs were included in the study.
RESULTS : A total of @number@ elderly Black adults took part in the study.
RESULTS : A total of @number@ elderly patients were included , with mean age of @number@.2±8.1 years , and males accounted for @percent@.
RESULTS : A total of @number@ eligible subjects agreed to participate , giving an attendance rate of @percent@.
Results : A total of @number@ eyes from @number@ patients ( @number@ HbSS and @number@ HbSC ) and @number@ eyes from @number@ controls were included.
RESULTS : A total of @number@ eyes of patients with a mean age of @number@.03± @time@ examined.
RESULTS : A total of @number@ eyes were included.
RESULTS : A total of @number@ family carers participated : @number@ were caring for people with early and @number@ with advanced COPD.
RESULTS : A total of @number@ feet were included in this study , and a total of @number@ radiographs were measured.
RESULTS : A total of @number@ frontline staff who provide nursing , nurse aide , and social work services responded to open-ended prompts.
RESULTS : A total of @number@ HAART users contributed @number@ person-years of follow-up.
RESULTS : A total of @number@ HCC patients with cirrhosis underwent major hepatectomy between @number@ and @number@
RESULTS : A total of @number@ HFpEF patients were included.
RESULTS : A total of @number@ hospitalized patients have been recruited.
RESULTS : A total of @number@ incident dementia cases were documented.
RESULTS : A total of @number@ incident NCD cases were identified from the cohort.
RESULTS : A total of @number@ individuals completed both surveys.
RESULTS : A total of @number@ individuals developed AF ( @number@ men , @number@ women ) .
RESULTS : A total of @number@ individuals ( @percent@ ) were diagnosed with dementia.
RESULTS : A total of @number@ individuals were included and followed during the study period.
RESULTS : A total of @number@ individuals with a history of fractures were included in this study.
RESULTS : A total of @number@ male residents were screened with mean age @number@ years ( range 46-99 ) .
RESULTS : A total of @number@ Medicare-eligible incident dialysis patients were studied.
RESULTS : A total of @number@ men and @number@ women was classified as cognitive impaired.
RESULTS : a total of @number@ men and women were eligible to be included in the study ( aged 40-79 years at baseline ) .
RESULTS : : a total of @number@ men died during a median of @number@ years of follow-up.
RESULTS : A total of @number@ men [ mean age @number@ ( SD @number@ ) yrs ] had complete data on pain status.
RESULTS : A total of @number@ men participated in the study.
RESULTS : A total of @number@ men ( @percent@ ) died during the follow-up period.
RESULTS : A total of @number@ men with an average age of @number@ years completed the study.
RESULTS : A total of @number@ mild NCD cases were identified.
RESULTS : A total of @number@ non-synonymous variants were identified in the CCHS.
RESULTS : A total of @number@ ( @number@ HCV positive ) AH cases were analyzed.
Results : A total of @number@ @number@ hospitalized patients who died from metastatic cancer were included.
RESULTS : A total of @number@ ( @number@ lobar ICH , @number@ deep ICH ) subjects were included.
RESULTS : A total of @number@ ( @number@ male and @number@ female ) patients with a fragility hip fracture were identified.
RESULTS : A total of @number@ @number@ ( @number@ men ; @number@ women ) study participants were registered in the study.
RESULTS : A total of @number@ @number@ patients were included in this study.
RESULTS : A total of @number@ @number@ people were examined.
RESULTS : A total of @number@ @number@ RVO cases ( @percent@ in women ) were identified.
RESULTS : A total of @number@ @number@ subjects aged 30-97 years from @number@ population-based studies were included in the meta-analysis.
RESULTS : A total of @number@ Offspring participants sustained strokes and @number@ developed AD.
RESULTS : A total of @number@ of @number@ study subjects ( @percent@ ) retired early through disability.
RESULTS : A total of @number@ % of subjects had cognitive impairment.
RESULTS : A total of @number@ of the @number@ patients ( @percent@ ) were rehospitalized during their home health 60-day episode of care.
RESULTS : A total of @number@ older Aboriginal people participated in ten Yarning Circles across six sites in the state of New South Wales.
RESULTS : A total of @number@ older adults were included in the analysis.
RESULTS : A total of @number@ older ED patients were enrolled.
RESULTS : A total of @number@ operations were performed with a mortality of @percent@.
RESULTS : A total of @number@ out of @number@ ( @percent@ ) nondepressed persons developed depressed mood during follow-up.
RESULTS : A total of @number@ out of @number@ ( @percent@ ) patients were ≥ @number@ years old.
RESULTS : A total of @number@ outpatients were analyzed.
RESULTS : A total of @number@ papers met the inclusion criteria.
RESULTS : A total of @number@ papers ( @number@ studies ) were included in this review.
RESULTS : A total of @number@ participants completed the study.
RESULTS : A total of @number@ participants completed the survey.
RESULTS : A total of @number@ participants from three randomized controlled trials were identified in this meta-analysis.
RESULTS : A total of @number@ participants fulfilled criteria for EM.
RESULTS : A total of @number@ participants had at least @number@ infarct.
RESULTS : A total of @number@ participants had eligible magnetic resonance imaging scans.
RESULTS : A total of @number@ participants included @number@ % who used OTC medicines and @number@ % who did not adhere to their prescriptions.
RESULTS : A total of @number@ participants in @number@ and @number@ participants in @number@ completed the survey.
RESULTS : A total of @number@ participants ( mean age @number@ years ; @number@ male ) were included in the analyses.
RESULTS : A total of @number@ participants ( @percent@ ) had MetS.
RESULTS : A total of @number@ participants ( @percent@ ) were diagnosed with AMD.
RESULTS : A total of @number@ participants were analyzed at the end of the study.
RESULTS : A total of @number@ participants were enrolled.
RESULTS : A total of @number@ participants were enrolled , and @number@ completed the study.
RESULTS : A total of @number@ participants were included , of whom @number@ and @number@ provided a second sample and third sample , respectively.
RESULTS : A total of @number@ participants with a mean age of @number@ ( @number@ ) years at baseline were included in the analysis.
RESULTS : A total of @number@ participant were enrolled at baseline.
RESULTS : A total of @number@ patient charts were reviewed.
RESULTS : A total of @number@ patient interviews were used in data analysis.
RESULTS : A total of @number@ patients ≥65 years underwent elective craniotomy at Loyola University Medical Center over @number@ years.
RESULTS : A total of @number@ patients ( age @number@ ± @number@ ) underwent scheduled cardiac surgery.
RESULTS : A total of @number@ patients and @number@ measurements were collected.
RESULTS : A total of @number@ patients completed the study.
RESULTS : A total of @number@ patients consisted of the intent-to-treat population , with @number@ in the per protocol analyses.
RESULTS : A total of @number@ patients had at least one cardiovascular event and were included in the self-controlled case-series analysis.
RESULTS : A total of @number@ patients had bile duct injury.
RESULTS : A total of @number@ patients had surgical extractions of impacted third molars under local anaesthesia during the period of the study.
RESULTS : A total of @number@ patients in each of the two groups were recruited.
RESULTS : A total of @number@ patients ( mean age @number@.3years , female @percent@ ) were hospitalized.
RESULTS : A total of @number@ patients ( mean age @number@ years ; men @percent@ ) were included in the study.
RESULTS : A total of @number@ patients ( mean age , @number@ years ) were included in this study.
RESULTS : A total of @number@ patients met inclusion criteria , and approximately @percent@ were prescribed opioids.
RESULTS : A total of @number@ patients met the inclusion criteria.
RESULTS : A total of @number@ patients ( @number@ men ; mean age @number@.9±5.8 years ) were enrolled.
RESULTS : A total of @number@ patients ( @number@ radiographs ) were included in this study.
RESULTS : A total of @number@ patients ( @number@ % ) were diagnosed with PMI after elective coronary intervention.
RESULTS : A total of @number@ patients ( @percent@ ) completed the study.
RESULTS : A total of @number@ patients ( @percent@ females ) were included in the analysis.
RESULTS : A total of @number@ patients ( @percent@ ) had AR , whereas @number@ ( @percent@ ) had NAR.
RESULTS : A total of @number@ patients ( @percent@ women , mean age @number@.5±3.2 years ) were recruited.
RESULTS : A total of @number@ patients receiving rivastigmine and @number@ @number@ patients receiving donepezil formed the study population.
RESULTS : A total of @number@ patients scheduled for decompression surgery for lumbar stenosis were enrolled into the study.
RESULTS : A total of @number@ patients undergoing RARP were queried.
RESULTS : A total of @number@ patients were available for analysis.
RESULTS : A total of @number@ patients were classified as elderly patients.
RESULTS : A total of @number@ patients were enrolled , and @number@ ( @percent@ ) of these had at least one follow-up visit.
RESULTS : A total of @number@ patients were enrolled , eight of whom tolerated the fMRI.
RESULTS : A total of @number@ patients were enrolled ( @number@ % males ; median age @number@ years ) .
RESULTS : A total of @number@ patients were enrolled , of whom @number@ were assigned to receive solanezumab and @number@ to receive placebo.
RESULTS : A total of @number@ patients were evaluated.
RESULTS : A total of @number@ patients were identified.
RESULTS : A total of @number@ patients were identified with AIH in @number@ retrospective studies.
RESULTS : A total of @number@ patients were included.
RESULTS : A total of @number@ patients were included.
RESULTS : A total of @number@ patients were included.
RESULTS : a total of @number@ patients were included in the data analysis ( age : @number@ ± @number@ years ) .
RESULTS : A total of @number@ patients were included in the study.
RESULTS : A total of @number@ patients were included in the study.
RESULTS : A total of @number@ patients were included in the study group.
RESULTS : A total of @number@ patients were included in the study resulting in a total of @number@ intracuff pressure readings.
RESULTS : A total of @number@ patients were included ; @number@ ( @percent@ ) women , median age @number@.5±2.45 years.
RESULTS : A total of @number@ patients were recruited ( mean age @number@ ± @number@ years ) , with @number@ robust and @number@ frail.
RESULTS : A total of @number@ patients were reported , and detailed data were analyzed for @number@ patients.
RESULTS : A total of @number@ patients were studied of whom @number@ had a TIA , @number@ a stroke and @number@ had other diagnoses.
RESULTS : A total of @number@ patients were treated between @date@ and @date@ .
RESULTS : A total of @number@ patients who completed the study ( @number@ with Alzheimer's Disease ( AD ) ) were re-evaluated 6months later.
RESULTS : A total of @number@ patients with a median age of @number@ yrs completed the diffusion tensor imaging-magnetic resonance imaging protocol.
RESULTS : A total of @number@ patients with an average age of @number@ ± @number@ years met the inclusion / exclusion criteria.
RESULTS : A total of @number@ patients with caregivers were included in the study.
RESULTS : A total of @number@ patients with gout and @number@ gout-free patients were included in the study.
RESULTS : A total of @number@ patients with IBS were enrolled from @number@ centres.
RESULTS : A total of @number@ patients with oesophageal cancer and @number@ patients with gastric cancer were included.
RESULTS : A total of @number@ patients with trauma ( @percent@ ) had TBI.
RESULTS : A total of @number@ people participated in the study and @number@ photographs were taken.
Results : a total of , @number@ ( @percent@ ) AD patients from SC and @number@ ( @percent@ ) from PC.
RESULTS : A total of @number@ ( @percent@ ) cases of incident cognitive decline were observed during the follow-up period.
RESULTS : A total of @number@ ( @percent@ ) individuals had endplate irregularities and @number@ ( @percent@ ) individuals had vertebral wedging.
RESULTS : A total of @number@ ( @percent@ ) of @number@ participants received a blood transfusion.
RESULTS : A total of @number@ ( @percent@ ) of @number@ records were available.
RESULTS : A total of @number@ ( @percent@ ) participants were classified as frail.
RESULTS : A total of @number@ ( @percent@ ) patients were found to have a mismatch between the IRA identified on CMR and CA.
RESULTS : A total of @number@ ( @percent@ ) patients were treated surgically , whereas @number@ ( @percent@ ) underwent an endovascular procedure.
RESULTS : A total of @number@ ( @percent@ ) subjects contributed with lung function measurements and bronchial provocation testing.
RESULTS : A total of @number@ ( @percent@ ) subjects submitted their two fecal samples according to our requirement in @number@ subjects.
RESULTS : A total of @number@ ( @percent@ ) women and @number@ ( @percent@ ) men participated in the study.
RESULTS : A total of @number@ pharmacists registered the management of @number@ alerts for @number@ patients.
RESULTS : A total of @number@ procedures were performed on @number@ symptomatic patients ( @number@ females ) .
RESULTS : A total of @number@ prospective cohort and eight case-control studies met our inclusion criteria.
Results A total of @number@ pts. were analyzed.
RESULTS : A total of @number@ publications , reporting on @number@ associations , were included in the review.
RESULTS : A total of @number@ publications were identified , and @number@ studies met the inclusion criteria.
RESULTS : A total of @number@ randomized controlled trials were identified.
RESULTS : A total of @number@ randomly selected subjects older than @number@ years of age were selected.
RESULTS : A total of @number@ RCTs involving @number@ participants were included in this meta-analysis.
RESULTS : A total of @number@ RCTs published between @number@ and @number@ met the inclusion criteria.
RESULTS : A total of @number@ rectal cancer survivors completed a mailed questionnaire.
RESULTS : A total of @number@ residents from nine different nursing homes , @number@ experts and @number@ nonexperts answered the questionnaires.
RESULTS : A total of @number@ residents took part in this study , with a response rate of @percent@.
RESULTS : A total of @number@ residents were surveyed , which including @number@ males and @number@ female subjects.
RESULTS : A total of @number@ respondents completed the study giving a response rate of @percent@.
RESULTS : A total of @number@ respondents were analysed.
RESULTS : A total of @number@ respondents were included.
RESULTS : A total of @number@ samples from @number@ preterm infants were analyzed.
RESULTS : A total of @number@ screening colonoscopy participants were included in the study.
RESULTS : A total of @number@ students were assessed.
RESULTS : A total of @number@ studies could be included in the meta-analysis.
RESULTS : A total of @number@ studies enrolling @number@ subjects met the inclusion criteria.
RESULTS : A total of @number@ studies involving @number@ participants were included.
RESULTS : A total of @number@ studies met inclusion criteria.
RESULTS : A total of @number@ studies met inclusion in the current systematic review.
RESULTS : A total of @number@ studies were identified.
RESULTS : A total of @number@ studies were identified by the search strategy , and @number@ meet all inclusion criteria.
RESULTS : A total of @number@ studies were identified , including @number@ patients with @number@ ± @number@ years of follow-up.
RESULTS : A total of @number@ studies were identified in the search , ten of which were included in the final review.
RESULTS : A total of @number@ studies were initially identified of which @number@ met the inclusion criteria.
RESULTS : A total of @number@ subjects completed all procedures.
RESULTS : A total of @number@ subjects completed the 5-year follow-up.
RESULTS : A total of @number@ subjects completed the examination.
RESULTS : A total of @number@ subjects completed the study ( n = 16 , FCR and n = 15 , control ) .
RESULTS : A total of @number@ subjects participated in the study ( @number@ patients with Alzheimer's disease and their caregivers ) .
RESULTS : A total of @number@ subjects were available for analysis ( mean age : @number@.1±6.3 years and @percent@ women ) .
RESULTS : A total of @number@ sublingual video-microscopy clips corresponding to @number@ time points from @number@ trauma patients were analyzed.
RESULTS : A total of @number@ surveys were completed with an overall survey response rate of @number@ %.
RESULTS : A total of @number@ temporal bones in @number@ patients ( @number@ men ) were diagnosed with PDTB.
RESULTS : A total of @number@ titles and abstracts were identified , @number@ full-text articles were obtained and @number@ were included in the review.
RESULTS : A total of @number@ treatment areas were evaluable at 1-3 months follow-up.
RESULTS : A total of @number@ unique institutions received awards.
RESULTS : A total of @number@ vertebrae were instrumented.
RESULTS : A total of @number@ women aged @number@.38±6.32 years were included.
RESULTS : A total of @number@ women ( @number@ in SISTEr and @number@ in TOMUS ) were included in analysis.
RESULTS : A total of @number@ women ( @percent@ ) were depressed at all three surveys over the 6-year survey period.
RESULTS : A total of @number@ women were investigated.
RESULTS : A total of @percent@ ( n = @number@ ) of the children were overweight at @number@ years of age.
RESULTS : A total of @percent@ of males and @percent@ of females were fatigued.
RESULTS : A total of @percent@ of participants reported ADL disability , and @time@ % for IADL disability.
RESULTS : A total of @percent@ of patients complained of xerostomia.
RESULTS : A total of @percent@ of patients were malnourished and @percent@ were ARM.
RESULTS : A total of @percent@ of study participants experienced activities of daily living impairment , and @percent@ experienced instrumental activities of daily living impairment.
RESULTS : A total of @percent@ of the participants experienced ≥1 fall , and @percent@ experienced ≥2 falls per year.
RESULTS : A total of @percent@ of the questionnaires were returned and analysed , and @percent@ of the responders gave blood samples.
RESULTS : A total of @percent@ of the respondents reported using the CHC during the past year.
RESULTS : a total of @percent@ participant reported 3-year incident mobility disability.
RESULTS : A total of @percent@ reported clinically relevant depressive symptoms and @percent@ reported probable depression.
RESULTS : A total of twenty-two articles were reviewed.
RESULTS : ATP ( @number@ mmol / L ) induced PS exposure on RBCs stored for less than @number@ week.
RESULTS : At rest , LV twist was lower in children , because of a higher temporal dispersion of peak rotation between base and apex.
RESULTS : Atrophy and lesion changes were commonly seen in each MRI test.
RESULTS : At the 28-year follow-up , @number@ of the @number@ participants had died and @number@ had some form of disability.
RESULTS : At the baseline evaluation , @number@ subjects were cognitively normal and @number@ subjects had MCI.
RESULTS : At the baseline visit , participants averaged @number@ ( SD : @number@ ) years of age and @number@ ( @percent@ ) were female.
RESULTS : At the end of the follow-up period , @number@ ( @percent@ ) patients were non-persistent with antiplatelet medication.
RESULTS : At the end of the study , participants showed improvements in the active aging outcome measures.
RESULTS : At the endpoint of the study , @number@ women and @number@ men had died.
RESULTS : At the follow-up examination @number@ of the @number@ patients were available and @number@ ( @percent@ ) had undergone cataract surgery.
RESULTS : At the start of cholinesterase inhibitor therapy ( time of AD diagnosis ) , @number@ individuals ( @percent@ ) were living alone.
RESULTS : At t₁₀ , @number@ new cases of diabetes were found.
RESULTS : At treatment completion , @percent@ ( N = 31 ) scored in pre-action and @percent@ ( N = 79 ) at action.
RESULTS : Attrition at @number@ months was @percent@ and @percent@ in the intervention and control arms respectively ( p = @number@ ) .
Results : At Wave @number@ @number@ ( @percent@ ) men and @number@ ( @percent@ ) women reported they often experienced moderate or severe pain.
RESULTS : A two-factor model was the optimal fit for the 14-item and 10-item versions of PSS.
RESULTS : A two-way between-subject factorial analysis of variance revealed a significant main effect for hand placement technique and gain response.
RESULTS : Authorities in the field have offered guidelines and recommendations regarding the diagnosis , evaluation , and management of hypogonadism.
RESULTS : Autophagy is the main mechanism of action of spermidine at the molecular level.
RESULTS : Autopolymerizing groups exhibited reduced DC means , whereas intermediate values were observed when resin cements were polymerized through the disk.
RESULTS : Autotaxin levels were significantly higher in MCI and AD.
RESULTS : Available evidence shows that a three-hit hypothesis can be drawn.
RESULTS : A valid cIMT exam was available for @number@ patients.
RESULTS : Average age of the @number@ participating Veterans ( @number@ Vietnam theater and @number@ non-theater ) was @number@ years.
RESULTS : Average age of the patients was @number@ ± @number@ years , @number@ % female and @number@ % male.
RESULTS : Average age was @number@ @number@ % perceived that they were happy.
RESULTS : Average BMI among older Japanese was @time@ baseline and decreased with an accelerating rate over time.
RESULTS : Average CT was not significantly different between controls and STGD patients.
RESULTS : Average momentary assessments were moderately positively correlated with retrospective ratings of PA and NA.
RESULTS : Average muscle loss was @number@ ± @number@.05% / year.
RESULTS : Average protein intake was @percent@ of energy intake ( SD = @percent@ ) .
Results : Average subfoveal CT showed a significant relationship with age ( P < @number@ ) and axial length ( P = @number@ ) .
RESULTS : Average surface in the CCS @number@ group was @number@ cm² statistically different when compared to the STARR group ( @number@ cm² ) .
RESULTS : Average walking speed was faster for the 6-m course and the second trial of each course.
RESULTS : A \ "Western \ " and a \ "healthy \ " DP were identified.
RESULTS : Back pain and severe motor deficits were the most common presenting symptoms.
RESULTS : Baicalin revealed strong antioxidant ability by directly scavenging superoxide and reacting with peroxynitrite.
RESULTS : Bakuchiol is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia.
RESULTS : Barium stimuli were rated as having reduced taste intensity compared with nonbarium stimuli.
RESULTS : Basal acid output ( BAO ) and maximal acid output ( MAO ) gradually decreased with age in H. pylori-negative subjects.
RESULTS : Basal carotid artery compliance was different among the groups ( P < @number@ ) .
RESULTS : Base case net benefits of Model @number@ and Model @number@ were $ 417.00 and $ 97.30 , respectively.
RESULTS : Based on objective measurement , only @percent@ of participants were sufficiently active ( n = @number@ ) .
RESULTS : Based on seven measures of sex composition , no protective effect of sons was found in either China or Taiwan.
RESULTS : Based on the experts ' consensus , a revised version of the FAQ , consisting of @number@ items , was produced.
RESULTS : Based on the previous day dietary recall method , exclusive breastfeeding was reported by @number@ ( @percent@ ) of the mothers.
RESULTS : Based on the results of the 2008 / 2009 survey , @percent@ of Canadians aged @number@ or older were at nutritional risk.
RESULTS : Baseline 3MS score predicted baseline functional status.
RESULTS : Baseline agitation , nighttime behaviors , depression , and apathy significantly increased the risk of incident dementia.
RESULTS : Baseline and week @number@ ABPM data were available for @number@ out of 178patients who entered the active treatment phase.
RESULTS : Baseline B12 levels ranged from 50-1690 pg / ml.
RESULTS : Baseline characteristics of thrombolysed and nonthrombolysed > 80 and ≤80-year-old patients with WUIS were comparable.
RESULTS : Baseline characteristics were similar between the groups.
RESULTS : Baseline clinical characteristics were similar between patients with and without CAVB.
RESULTS : Baseline cognitive impairments were common.
RESULTS : Baseline data demonstrated that subjects > 55 years of age had a later onset of asthma and a longer duration of symptoms.
RESULTS : Baseline MCI prevalence varied between @percent@ and @percent@ and dementia conversion between @percent@ and @percent@ across different algorithms.
RESULTS : Baseline mean HbA1c level was @percent@ ; mean age , @number@ years ; and mean duration of T2DM , @number@ years.
RESULTS : Baseline median YKL-40 was higher in CHI than AHI ( @number@ versus @number@ ng / l ; P = @number@ ) .
RESULTS : Baseline prevalence of pain was @percent@ ( @percent@ CI @number@.3-38.3 ) .
RESULTS : Baseline proximal UE-FMA scores significantly predicted clinically important improvement on the primary outcome measure after all @number@ interventions.
RESULTS : Baseline serum concentrations of both forms of OC were significantly lower in case subjects than in control subjects.
RESULTS : B cell populations of three out of four reactive Lymph node tissues were composed of several clones.
RESULTS : BCI accuracy and communication rate did not differ significantly between ALS users and HVs.
RESULTS : BD participants demonstrated slower PS compared with the HC group , but no group differences were found in FA across tracts.
RESULTS : BD patients displayed significantly lower performances in processing speed and episodic memory but not in working memory and executive functions compared to controls.
Results bear statistical and clinical significance , given that we are examining racial and ethnic groups.
RESULTS : Because of the heterogeneity of the measurements , it was deemed inappropriate to conduct a meta-analysis and thus a narrative approach was employed.
RESULTS : Beer , wine or spirit preference was not related to diabetes risk compared with having no preference.
RESULTS : Before bed rest , the FDR subjects revealed significantly increased glucose uptake in SCAAT.
Results : Before retirement there was a slight decrease in sleep duration.
RESULTS : Beginning in @number@ @number@ oncologists and radiation oncologists were active and supplying @number@ full-time equivalents ( FTEs ) of patient care.
RESULTS : Behavioral performance of the KPT degraded compared to its single task components.
RESULTS : Behavioral variant of FTD was the most common clinical subtype ( @percent@ and @percent@ in familial and sporadic cases , respectively ) .
RESULTS : Bereaved spouses who reported prolonged forewarning of the death evidenced higher cortisol levels at W1 than those who did not experience prolonged forewarning.
RESULTS : Best-corrected logMAR VA worsened over time ( slope = @number@ intercept = @number@ both p < @number@ ) .
RESULTS : Best corrected visual acuity ( BCVA ) improved in @number@ of @number@ eyes ( @percent@ ) .
RESULTS : Best fitting the data is a model with @number@ groups characterized as early , mid , and late onset of limitation.
RESULTS : Better mental status was associated with more concordant reporting and less underreporting on disease history and the number of hospital episodes.
RESULTS : Better performance in several tests of verbal memory , verbal fluency and executive function was indeed associated with higher hippocampal neural activity.
RESULTS : Better sleep quality was associated with better Stroop performance and higher proportions of the gut microbial phyla Verrucomicrobia and Lentisphaerae.
RESULTS : Better vision and worse speech were associated with more frequent e-mail contact with the selected child.
RESULTS : Between 2004-2006 , NAMBTS sold @number@ RCC units to public sector facilities.
RESULTS : Between @date@ and @date@ , @number@ consecutive patients were admitted with a hip fracture to @number@ community and @number@ academic hospitals.
RESULTS : Between @date@ and @date@ , @number@ URI episodes , including @number@ with LRI , in @number@ infants were documented.
RESULTS : Between @date@ and @date@ we enrolled and randomized @number@ participants taking at least one medication with anticholinergic properties.
RESULTS : Between @number@ and @number@ among @number@ male LTRs , @number@ ( @percent@ ) had PC.
RESULTS : Between @number@ and @number@ a total of @number@ prostate cancer cases were diagnosed in Tianjin.
RESULTS : Between @number@ and @number@ @number@ CD and @number@ CF Medicare patients were identified in the dataset.
RESULTS : Bilateral hearing impairment was identified in @percent@ of participants and DSI in @percent@.
RESULTS : Bioavailability was estimated using model-independent and model-dependent procedures.
RESULTS : biochemical hyperandrogenism was found in @number@ of @number@ eligible patients ( @percent@ ) .
RESULTS : Bipolar disorder patients presented shorter telomeres when compared to controls ( p < 0.001 ) .
Results : Bisexual older adults reported significantly poorer health compared with lesbian and gay older adults.
RESULTS : Black participants were more likely to have fewer years of education and lower household income.
RESULTS : Blacks and Hispanics reported poorer self-rated oral health than Whites.
RESULTS : Blacks represented @percent@ of the participants at year @number@
RESULTS : Bleaching increases the amount of elutable substances.
RESULTS : Blood bank storage significantly affects metabolic profiles of RBC extracts and supernatants by Day @number@
RESULTS : Blue-collar workers have significantly earlier mean ANM ( @number@ years ) than white-collar workers ( @number@ years ) .
RESULTS : BMI among the employed was higher than among the unemployed for those under @number@
RESULTS : BMI calculated using the tallest height and BMI calculated using actual height both had strong correlations with %BF.
RESULTS : BMI increased linearly over time.
RESULTS : BMI values and WC were stronger related in father-offspring than in mother-offspring pairs.
RESULTS : BMI was strongly and positively associated with kOA in men and women.
RESULTS : BmMSCs and ucMSCs showed decreasing proliferative capacity over time , while their telomere lengths and mitochondrial activity remained stable.
RESULTS : Body composition growth charts were based on a total of @number@ measurements of body composition obtained from @number@ infants.
RESULTS : Body weight , % body fat , and energy metabolism did not change with bed rest.
RESULTS : Body weight increases because the decline in physical activity during the perimenopause is greater than the concomitant decline in energy intake.
RESULTS : Bond strength higher than @number@ MPa was considered clinically sufficient.
RESULTS : BoNT / A injection showed superior effects at @number@ and @number@ weeks.
RESULTS : Bootstrapping was used to examine mediation models.
RESULTS : Both adhesives and water storage time affected the mTBS.
RESULTS : Both age groups learned associative regularities , but age differences in favor of the young emerged with practice.
RESULTS : Both age groups showed significant improvements in depression symptoms.
RESULTS : Both approaches showed successful replication in the new data set.
RESULTS : Both DTP and UTP concentrations progressively decrease from nonfrail to frail participants.
RESULTS : Both experiments confirmed the presence of a larger dual-task cost in older adults than in young adults.
RESULTS : Both groups demonstrated an increase in sound pressure level and fundamental frequency from habitual voice to high intensity voice.
RESULTS : Both groups had similar muscle and lean body mass indices and activity level.
RESULTS : Both groups improved their performance from pre- to post-test.
RESULTS : Both groups increased amino acid concentrations ( P < @number@ ) and mTORC1 signaling after protein ingestion ( P < @number@ ) .
Results : Both groups of speakers produced steeper F2 slopes for the diphthongs in less frequent words and words from sparse neighborhoods.
RESULTS : Both groups presented a significant decrease in glycemia and diastolic blood pressure levels.
RESULTS : Both groups reported high levels of functional impairment and Axis I comorbidity.
RESULTS : Both intervention groups significantly improved their social participation , and their upper- and lower-body strength scores.
RESULTS : Both logarithmic and potential functions provide a good fit for the data ( R2 = @number@ and @number@ respectively ) .
RESULTS : Both magnitude and phase data showed an increase in putative iron content with age.
RESULTS : Both neutrophil infiltration and NE activity were elevated in photoaging.
RESULTS : Both older and mid-aged adults had significantly increased JPS error compared with younger adults ( P < .05 ) .
RESULTS : Both parameters were significantly improved following treatment with either form of CoQ10 , suggesting the effectiveness of CoQ10 in attenuating dry mouth symptoms.
RESULTS : Both perceived levels of social control and personal control had a statistically significant relationship with functional health status.
RESULTS : Both physical and mental activity groups performed better over time than the control group ( p < @number@ ) .
RESULTS : Both products showed immediate , good results after injection and touch-up and demonstrated good durability over time.
RESULTS : Both PSG and self-reported sleep measures confirmed that sleep is altered in patients with MCI.
RESULTS : Both psychosis and depressed mood at study entry were associated with worse subsequent cognitive decline.
RESULTS : Both repeated and novel biomeasures were successful.
RESULTS : Both simultaneous and lagged coefficients indicated that a high score on flexible goal adjustment significantly predicted subsequent levels of life satisfaction.
RESULTS : Both stroke groups were significantly poorer than normal controls for the MEB total score and its subtests ( p < @number@ ) .
RESULTS : Both %SUV and binding values increased with age linearly in the whole brain and in all brain regions.
RESULTS : Both the aerobic training and resistance training interventions were less costly than twice weekly balance and tone classes.
RESULTS : Both the AMI and the AI showed a temporally graded retrograde amnesia in the Korsakoff patients for personal semantic and episodic autobiographical memories.
RESULTS : Both the concentration of IGFBP-3 and the IGF-I to IGFBP-3 ratio are mainly determined by age.
RESULTS : Both the knowledge and certainty construct of the KOP-Q proved unidimensional in the Netherlands and USA sample.
RESULTS : Both the younger and the older group demonstrated a significant improvement in postimplant HINT and / or AZBio scores.
RESULTS : Both treatment conditions did not affect viability but significantly increased the expressions of MMP-1.
RESULTS : Both treatment group and urine volume were strong independent predictors of urine calcium concentration ( p < @number@ ) .
RESULTS : Both young and older adults solved problems violating parity rule and five rule more quickly than problems violating no rule.
RESULTS : Boys with ADHD had smaller total caudate volumes relative to controls , F ( @number@ ) = 4.29 , p = 0.04.
RESULTS : Brainstem Lewy bodies were associated with depressive symptoms , and the association was attenuated in those taking antidepressant medication.
RESULTS : BRD prevalence among older adults suffering from depression was @percent@.
RESULTS : Brenden was more mobile and had more vocalizations during the 12-week intervention.
RESULTS : BV was prevalent in @percent@ and @percent@ of postmenopausal women in Waves @number@ and @number@ and increased with age.
RESULTS : By design , older participants were active for longer ( 49±5 versus 6±4 years , P < 0.05 ) .
RESULTS : By @number@ @number@ men of the baseline cohort had died , and @number@ men responded to the mailed survey.
RESULTS : By simulation , we identified pleiotropic regions including SH2B3 and BRAP ( 12q24.12 ) for hematologic and blood pressure traits.
RESULTS : By year @number@ cognitive impairment was diagnosed in 15-38% participants depending on the criteria applied.
RESULTS : CA and RF led to collagen remodeling ; however , this result was more evident and lasted longer with RF.
RESULTS : CAB distinguished very clearly between controls and MCI as well as MCI and dementia.
RESULTS : CaHA has good safety , efficacy and tolerability profiles that are comparable to those of hyaluronic acid ( HA ) fillers.
RESULTS : Calcium intake influences skeletal calcium retention during growth and thus affects peak bone mass achieved in early adulthood.
RESULTS : Calibrated protein intake ranged from @percent@ to @percent@ energy.
Results call attention to inconsistencies in reporting of reliability , validity , and heterogeneity in the measurements and operational definition for cognitive frailty.
RESULTS : Cancer appeared to be a family matter.
RESULTS : Cancer survivors and those without a cancer diagnosis had similarly low rates of adherence to PA guidelines according to age group.
RESULTS : Cancer survivors had significantly higher total and cancer-specific domain scores compared to unexposed participants.
Results can guide practice and intervention with ethnically diverse older women who may be struggling to communicate about their sexual health concerns.
Results can inform national and international education efforts about AD and other dementias.
RESULTS : CAP and brachial arterial pressure tended to increase and renal function declined with age.
RESULTS : CAPE dependency RCS funding per resident per day varied from $ 32.20 for grade A to $ 116.20 for grade E4 residents.
RESULTS : Cardiac events occurred in @number@ patients ( @percent@ ) .
RESULTS : Cardiovascular symptoms ( @percent@ ) and pulmonary symptoms ( @percent@ ) were commonly experienced by U.S. Chinese older adults.
RESULTS : Caregivers considered decisions to stop cancer screening in terms of quality of life and burden on the patient and caregiver.
RESULTS : Caregivers presented mild anger levels and showed expression-in rather than expression-out of anger.
RESULTS : Caregivers showed increasing functional limitations and decreasing bodily pain over time , whereas role limitation and general health perception remained stable.
RESULTS : Care quality improved substantially over time in both arms.
RESULTS : Carers had a significant role in navigating services and operationalising care for their relative.
RESULTS : Care teams are minimally comprised of general practitioners or primary care providers , nurses , and social workers.
RESULTS : Care transition patterns remained consistent from year to year.
RESULTS : Care was rendered to @number@ patients over the first @number@ months of TECS.
RESULTS : Carotid plaque was detected in @number@ ( @percent@ ) persons.
RESULTS : Case-control studies including @number@ cases and @number@ controls were identified.
RESULTS : Cases and controls had similar enrollment matching characteristics.
RESULTS : Cases of elderly patients amounted to a stable @number@ % of all cases from @number@ until @number@
RESULTS : Caspase-3 and caspase-8 specific inhibitors suppressed HCT-induced cell death.
RESULTS : CCA and ICA PI were significantly correlated to femPWV ( ρ = @number@ and ρ = @number@ respectively ) .
RESULTS : CDST significantly improved spatial cognition and decreased beta-APP expression in the cortex and hippocampus ( P < @number@ P < @number@ ) .
RESULTS : Cell and nucleus diameters , cell density and FLIM vary according to the epidermal cell depth and the skin site.
RESULTS : Cells from the stromal vascular fraction ( SVF ) and subsequent cultured ASC were prepared.
RESULTS : Cell transplantation was an overall safe and well-tolerated procedure.
RESULTS : cfPWV increased in ESRD patients compared to control subjects.
RESULTS : CGGT participants demonstrated higher treatment response than TAU participants.
RESULTS : Changes in delta bandpower showed the highest and most consistent pattern of correlations with longitudinal changes in neuropsychological testing.
RESULTS : Changes in physical activity and body weight are associated with depressive symptoms after adjusting for confounders.
RESULTS : Changes in VAS and WOMAC scores were calculated for both knees as baseline minus post-treatment.
RESULTS : Changes of the lids in the XP group included blepharitis in @number@ patients , distichiasis in @number@ and madarosis in @number@ patients.
RESULTS : Changing economic conditions introduced barriers requiring recruiting a larger number of study sites.
RESULTS : CHD was identified in @number@ ( 7·9 % ) women.
Results : Childhood abuse was associated with caregiver abuse screen results ( odds ratio = @number@ @percent@ confidence interval = @number@ @date@ ) .
RESULTS : Children had a median age of @number@ years and @percent@ were boys.
RESULTS : Chinese older adults mostly characterized elder mistreatment in terms of caregiver neglect and identified psychological mistreatment as the most serious form of mistreatment.
RESULTS : Chinese workers were generally more likely to report adverse exposures.
RESULTS : Cho / Cr and NAA / Cr ratios were decreased and Glx / NAA ratio increased in MS patients vs CON.
RESULTS : Chronic cough and expectoration ( @percent@ ) and breathlessness during exercise ( @percent@ ) were commonly reported.
RESULTS : Cigarette price was mentioned most often in all countries and across all waves as trigger for thinking about quitting.
RESULTS : Cigarette smoking status , smoking pack-years , duration , intensity , and age at initiation were not associated with male breast cancer risk.
RESULTS : CIMT was significantly higher among older people and T / S ratio was significantly higher in young women.
RESULTS : Circulating levels of amino acids except threonine and tyrosine were significantly higher in GDM women than non-GDM women.
RESULTS : Classes included health provider plus clergy , physician plus mental health provider , and limited provider use.
RESULTS : Classification of nasolabial and periorbital wrinkles did not show any significant difference between groups.
RESULTS : Clinical guidelines support the use of opioids in persistent nonmalignant pain.
RESULTS : Clinical POPF ( ISGPF Grade B and C ) was seen in @number@ of @number@ patients ( @percent@ ) .
RESULTS : Clostridium difficile infection discharges increased from @number@ per @number@ persons in @number@ to @number@ per @number@ persons in @number@
RESULTS : Cocaine at @number@ and @number@ μM significantly increased human astrocyte proliferation.
RESULTS : Cocultured adipocytes increased myotube mRNA expression of genes involved in oxidative metabolism , regardless of the donor and degree of lipolytic activity.
Results : Cognition and BPSD were not associated with expenditures.
RESULTS : Cognitive behavioral therapy focused on problem solving is the main approach studied , having better effectiveness than supportive therapy in randomized clinical trials.
RESULTS : Cognitive debriefings started with HCAs.
RESULTS : Cognitive impairment was found in @number@ ( @number@ % ) patients.
RESULTS : Cognitive impairment was found in @percent@ of HIV-infected individuals.
RESULTS : Cognitive impairment was observed in MHE rats and DA ( @number@ µg , i.c.v. ) -treated rats.
RESULTS : Cognitive impairment was observed in mice exposed as infants but not as adults.
RESULTS : Cognitively normal FH + individuals had significantly increased whole-brain gray matter atrophy and CSF expansion compared to FH-.
RESULTS : Cognitive scores were significantly higher in the @number@ sample.
RESULTS : Cognitive test data were available for @number@ men and women taking part in EPIC-Norfolk @number@
RESULTS : Community was the major explanatory factor for patients ' choice of facility , probably reflecting a tendency to use the closest facility.
RESULTS : Compared to controls , AD had smaller volumes of ERC , subiculum , CA1 , CA1-2 , and total hippocampal volumes.
RESULTS : Compared to @number@ the number of deaths and the overall age-standardized mortality increased in @number@ by @number@ and @percent@ , respectively.
RESULTS : Compared to older adults who are food secure , those who are food insecure have an increased risk for PAD.
RESULTS : Compared to older adults without ADHD , those with ADHD reported more serious conflicts.
RESULTS : Compared to Spanish-born participants , Latin American-born participants reported higher health-related quality of life in the physical functioning and vitality dimensions.
RESULTS : Compared to the IG and CG , positive attitudes towards older adults increased in the IGVoA after the intervention.
RESULTS : Compared to WT mice , TLR4 KO mice showed reduced preference for lipids , sugars , and umami in a two-bottle preference test.
RESULTS : Compared with adults , children showed T-cell predominance in the skin.
RESULTS : Compared with all other parts of the brain , the cerebellum had the highest SUV.
RESULTS : Compared with females , males had longer , larger and higher feet.
RESULTS : Compared with the control group , the PST-HC group showed a significant decrease in depression but not anxiety scores.
RESULTS : Compared with the Elder-Healthy group , the Elder-HD group showed a lower total BHEI-R score ( P < @number@ ) .
RESULTS : Compared with the MT and MT + sham groups , the MT + MG group demonstrated improved muscular properties.
RESULTS : Compared with the young , older individuals exhibited significantly weakened CMC at all force levels tested.
RESULTS : Compared with younger drivers , older drivers showed a reduced frequency of visual inspection toward the rearview mirror and the blind spot.
RESULTS : Compared with young subjects , the older subjects had significantly slower tapping rates in all fingers and finger-pairs in the tapping tasks.
RESULTS : Complete data were available for @number@ cancer patients , including @number@ subjects who were over @number@ years old.
RESULTS : Completed responses were received from @number@ and @number@ practising optometrists in Australia and New Zealand , respectively.
RESULTS : Complete frailty screening data were available for @number@ patients.
RESULTS : Completely sclerotic glomeruli were not found in the first group.
RESULTS : Complex instrumental activities of daily living were subject to greater impairment than basic activities of daily living.
RESULTS : Compliance was high in @percent@ and low in @percent@ of the IG ( n = 42 ) .
RESULTS : Complicated patients were older , were sicker , and required increased ventilator days compared with the intermediate / uncomplicated patients.
RESULTS : Complications or reoperations between the approaches were not different.
RESULTS : Components of caregiver QoL correlated with caregiver-rated functional impairment , family accommodation , youth externalizing behaviors , and caregiver psychopathology.
RESULTS : Compromised BBB integrity was found in both MPS III cases.
RESULTS : COMT-Val + carriers performed more poorly on tests of attention , verbal fluency , and motor speed relative to COMT-Met homozygotes.
RESULTS : Concentrations of γ-tocopherol and δ-tocopherol decreased significantly , and α-carotene significantly increased in GBS patients compared to healthy controls.
RESULTS & CONCLUSIONS : Abstracts ( @number@ ) were screened and @number@ articles were reviewed in full.
RESULTS & CONCLUSION : The minimum inhibitory concentration of N12D and N23D against MRSA was @number@.9-9.8 and @number@ μM , respectively.
RESULTS & CONCLUSION : We developed an accurate tool for predicting gestational age of placentas using @number@ CpG sites.
RESULTS : Concordance between scan results and baseline diagnosis was high ( PiB @percent@ , FDG @percent@ ) .
RESULTS : Concurrent associations between AUD and CUD were significant.
RESULTS : Conditional logistic regression analyses and within-pair correlation analyses suggested positive associations between verbal development and drinking behaviors in both data sets.
Results confirm , as in many developing countries , a higher proportion of older Barbadians receive rather than provide support.
RESULTS : Confirmatory factor analysis supported the MBI-HSS as an acceptable measure to evaluate burnout in ID services staff.
RESULTS : Confirmatory factor analysis supported the two-factor model as having the best fit.
RESULTS : Confirmatory factor analysis supports a second-order model comprising one second-order factor and four first-order factors of RFS.
Results confirmed a general age benefit for real-life PM tasks.
Results confirmed an age-associated increase in N1 amplitude to auditory stimuli under the auditory-ignore but not auditory-attend task.
Results confirmed previous reports that older head injury victims in motor vehicle collisions were more likely to sustain bleeding injuries than younger head injury victims.
Results confirmed that impacts of vision loss on AVL are mediated by decline in functional ability.
Results confirmed that MOX had a positive effect on colour density , even after @number@ months of bottle aging.
Results confirmed the inverted U-shaped function of prospective memory performance across the lifespan.
Results confirm intravenous peramivir's usefulness.
RESULTS : Consensus was achieved for @number@ ( @number@ % ) of the @number@ medications and medication classes included in the survey.
RESULTS : Considered together , the findings can be viewed as manifestations of a need and desire for security in palliative family caregiving.
RESULTS : Consistently , dietary fiber intake remained below recommended adequate intake levels for total fiber defined by the Institute of Medicine.
Results consistently showed that women , in contrast to men , displayed a reliable own-gender bias.
RESULTS : Consistent with previous findings , we observed reductions in worry frequency and increases in physical symptom frequency with increasing age of participants.
RESULTS : Consistent with previous theories older adults experiencing MDS reported greater difficulties in regulating affect compared to normal controls ( NCs ) .
RESULTS : Content and face validity of the questionnaire was confirmed by experts.
RESULTS : Continuous ambulatory monitoring better indicates the increase of systolic tension and the reduction of the diastolic tension by aging.
RESULTS : Contrast sensitivity was reduced and straylight increased in all cataract patients , most notably in posterior subcapsular and nuclear-cortical cataract.
Results contribute to the present literature by offering some framework for developing effective , accessible , sustainable , and less costly interventions.
RESULTS : Control participants performed better than both aMCI and AD patients on olfactory identification.
RESULTS : Controls ( N = @number@ ) were compared with @number@ opiate dependent men.
RESULTS : Co-resident caregivers of spouse and children experienced more depressive symptoms than other relationship co-resident caregiving dyads.
RESULTS : Corneocyte detachment observed with dermatoscopy became more prevalent with age and was more severe on the dorsal forearm and in Caucasian subjects.
RESULTS : Corn oil supplementation had no effect on the muscle protein synthesis rate and the extent of anabolic signaling element phosphorylation in muscle.
RESULTS : Coronary angiography revealed a higher incidence of multivessel coronary artery disease in this elderly patient population.
RESULTS : Correct recall scores were lower for early positions compared with the latter positions , irrespective of listening condition.
RESULTS : Correlational analyses revealed that simple relationships between PD scales with GSIS subscales were generally stronger than with RFL subscales.
RESULTS : Correlations between the accelerometer metrics and DLW-determined PAEE were higher for triaxial counts than vertical axis counts.
RESULTS : Correlations ( @percent@ to > 90% ) between dermatologists were all statistically significant ( P < @number@ ) .
RESULTS : Correlations were largely non-significant ( except for stroke ) .
RESULTS : Cortical vitreous contains fibrillar collagens type II , V / XI , and IX.
RESULTS : COs reported significantly higher prevalence and intensity of LE symptoms compared to the industrial workers.
RESULTS : Covariant perfusion principal components ( PCs ) were not associated with either FC or cognitive or attentional measures in AD.
Results : CPAP withdrawal caused recurrence of OSA associated with hypoxemia , sleep disruption , and heart rate ( HR ) elevation.
RESULTS : Creatine kinase was higher at @number@ h , 3h , 24h and @number@ h following the ERE for the HR group.
RESULTS : Cronbach's Alpha of @number@ ( n = @number@ ) showed a good internal consistency of the Arabic ADAM questionnaire.
RESULTS : Cross-sectional analyses showed that height and thigh muscle area were positively and visceral adipose tissue negatively related to FEV1 and FVC.
RESULTS : Cross-sectionally , each drusen feature was associated with a higher frequency of the CFH and ARMS2 risk variants.
RESULTS : Cross-sectionally , mean LTL shortenings were @number@ @number@ and @number@ bp / y at S1 , S2 , and S3 , respectively.
RESULTS : Crowding estimates were higher for nursing homes and in dining and activity rooms.
RESULTS : CRT-treated survivors demonstrated significantly decreased FA compared with controls in frontal , parietal , and temporal WM tracts.
RESULTS : Crude and standardized mortality rates showed an upward trend for Brazil and its regions more than 2-fold the last @number@ years.
RESULTS : Crude HP prevalence was @number@.949 / 100 @number@ population.
RESULTS : CSF CD8 T cells were elevated in AHI compared with uninfected controls.
RESULTS : CT measurements were available for @number@ ( @percent@ ) students ( mean age : @number@.8±3.5 years ; range : 7-21 years ) .
RESULTS : Cumulative fibre > 60 fibre-months / cc showed a significant loss in lung function at the first test.
RESULTS : Cumulative results of CBC and HbA1c could be retrieved for @number@ outpatients aged @number@ years or older throughout the study period.
RESULTS : Cumulative trauma exposure predicted greater PTSD symptom severity in hierarchical regression analyses consistent with a dose-response model.
RESULTS : Curcumin dose-dependently reduced uptake of oxLDL in THP-1 cells.
RESULTS : Current best available evidence suggests that DHEA improves ovarian function , increases pregnancy chances and , by reducing aneuploidy , lowers miscarriage rates.
RESULTS : Current demographic trends leading to an increased number of individuals surviving past age @number@ will result in an increased number of osteoporotic fractures.
RESULTS : Current research efforts show that assistive information and communication technologies can successfully contribute to all dimensions of elderly's quality of life.
RESULTS : Cutpoints derived from Weak CONCLUSION : The ALM OBJECTIVES : To investigate the relationship between polypharmacy and frailty.
RESULTS : CVD prevalence rates were more than 6-fold higher in Framingham men and women than their Fukuoka counterparts ( P < @number@ ) .
RESULTS : CVD was significantly , negatively related to CPS ( β = @number@ @percent@ CI [ @number@ @number@ ] ) .
RESULTS : CV%RMS ranged from @number@ to @number@ %.
RESULTS : Cyclic stretch significantly induced ESC secretion of CXCL8 and CXCL1 and neutrophil chemotaxis.
RESULTS : Cycloplegic refraction data and biometry were obtained from @number@ subjects , of whom @number@ ( @percent@ ) were women.
RESULTS : Daily AEE declined @number@.61±293.25 kcal , which equated to a @number@.63±40.57 kcal / d decrease per year.
RESULTS : Daily intake of supplemental iron failed to produce any increment in urinary excretion of TBARS or 8-OHdG.
RESULTS : Daily pedometer steps ranged from @number@ to @number@
RESULTS : Daily positive experiences were associated with improved as well as disrupted subsequent sleep.
RESULTS : Damageable , nonlinear elastic biomechanical behavior is observed.
RESULTS : Data about peanut allergy were scarce in most developing countries.
RESULTS : Data analysis shows a significant negative correlation for all parameters and subject's age.
RESULTS : Data are available for @number@ GPs ; @number@ patients ( cycle @number@ ) and @number@ patients ( cycle @number@ ) .
RESULT ( S ) : Databases were searched for the literature published up to @date@ .
RESULTS : Data for @number@ @number@ persons were analyzed.
RESULTS : Data for @number@ patients were included , with a mean ± SD age of @number@ ± @number@ yr.
RESULTS : Data from analyzed studies , both gastro esophageal and pancreatic cancer , are contradictory.
RESULTS : Data from anthropometric measurements were available for @number@ men and @number@ women in the age group from @number@ to @number@ years.
RESULTS : Data from eight studies with @number@ patients were included in the final analysis.
RESULTS : Data from @number@ adults over the age of @number@ years were analyzed.
RESULTS : Data from @number@ Chinese nonagenarians and centenarians were included.
RESULTS : Data from @number@ community-dwelling older adults ( @percent@ women ) were analyzed.
RESULTS : Data from @number@ intervention groups were combined for the current analysis.
RESULTS : Data from @number@ patients ( @number@ sugammadex , @number@ neostigmine and @number@ no-reversal ) were analysed.
RESULTS : Data from @number@ STEMI patients were used.
RESULTS : Data from @number@ subjects remained for final analysis.
RESULTS : Data of @number@ cancer survivors were collected of whom @number@ ( @percent@ ) were immigrants.
RESULTS : Data of @number@ participants were analysed , mean age @number@ ± @number@ @percent@ female , and @percent@ frail.
RESULTS : Data on @number@ dental patients extracted comprised of @number@ treatment procedures delivered across @number@ courses of care.
Results : data on @number@ ( intervention = @number@ usual care = @number@ ) participants were analysed using intention to treat analysis.
RESULTS : Data show that the highest rankings were accorded to \ "treatment for children \ " and \ "high technology services. \ "
RESULTS : Data was available for @number@ patients with a mean age of @number@ ( @number@ ) y.
RESULTS : Data were analyzed for @number@ HIV + and @number@ uninfected participants.
RESULTS : Data were assessed for @number@ learners who completed the activity.
RESULTS : Data were available from @number@ participants.
RESULTS : Data were collected from @number@ articles , capturing @number@ patients.
RESULTS : Data were pooled from nine studies.
RESULTS : Death at @number@ year increased markedly with age ( from @percent@ for 65-79 years to @percent@ for ≥90 years ) .
RESULTS : Decline and acceleration of this decline were detectable in the period before death.
RESULTS : Decline in absolute toe flexor and handgrip strength began in the age groups 50-55 and 55-59 years , respectively.
RESULTS : Decline in the ability to understand speech in complex listening environments can be demonstrated in midlife.
RESULTS : Decreased response accuracy and parietal late positive component EP amplitude in the episodic memory task best characterized impaired subjects.
RESULTS : Decreases in maximum voluntary contractions ( older : @percent@ ; young : @percent@ ) and electromyographic activity were not different between groups.
RESULTS : Delirium occurred in @number@ of @number@ patients ( @number@ % ) .
RESULTS : Delirium occurred in @number@ patients ( @percent@ ) and patients with delirium were significantly older than patients who did not develop delirium.
RESULTS : Delirium was diagnosed in @number@ of @number@ patients ( @percent@ ) who underwent assessment.
RESULTS : Delirium was identified in @percent@ of new postacute nursing home admissions.
RESULTS : Dementia was diagnosed in @number@ individuals ( @percent@ ) .
RESULTS Dementia was diagnosed in @number@ ( @percent@ ) patients.
RESULTS : Demographic and tumor characteristics of laparoscopic and ODP were similar.
RESULTS : Demographic and tumor characteristics of laparoscopic and OLRs were similar.
RESULTS : Demographic characteristics accounted for significance variance in IADLs ( p = @number@ R ( @number@ ) = @number@ ) .
RESULTS : Demographic variables indicate that individuals that are illiterate demonstrate a @number@ fold ( p = @number@ ) increase in risk of developing AD.
Results demonstrate a sex-related difference in the absolute number of total , neuronal and non-neuronal cells , favoring women by 40-50%.
Results demonstrate a significant speedup of @number@.73-fold can be achieved for the development of MI classification model.
Results demonstrated an age-related decline in both object identification and localization.
Results demonstrated a predominance of aggressive dream imagery in the adolescent age group in line with social-developmental research.
Results demonstrated a significant increase of the epidermal mitotic index , significant dermal collagen remodeling and significant increases in both epidermal and dermal GAGs.
Results demonstrated homogeneous characteristics sample.
Results demonstrated that FUS-BBB opening caused the local TMZ accumulation in the brain to increase from @number@ to @number@ ng / mg.
Results demonstrated that the various qMRI measures were highly interrelated and that corrected measures proved to be the most robust measures related to neuropsychological performance.
Results demonstrated the feasibility of describing strengths of patients with chronic illness.
Results demonstrate for the first time that , in a demanding listening task , instantaneous acoustic conditions guide the allocation of attention.
Results demonstrate non-rapid eye movement sleep electroencephalographic abnormalities in PD patients.
Results demonstrate significantly increased left-hemispheric theta phase synchronization in AP compared with non-AP musicians.
Results demonstrate significant reductions in sway amplitude and sway variability for the difficult discrete task as well as the continuous tasks relative to single-task standing.
Results demonstrate strong age differences in movement time ( MT ) , with longer and more variable MT in older adults.
Results demonstrate that advantaged circumstances during childhood are associated with lower levels of labour market disadvantage and higher quality of life in older ages.
Results demonstrate that bioaccessibility of As , Cd and Pb reached a steady state after soils were aged for @number@ days.
Results demonstrate that the technique has the sensitivity to detect hemodynamic changes after CEA.
RESULTS : Denture status associated with food choices.
RESULTS : Deoxycholic acid causes adipocyte breakdown and an inflammatory tissue reaction leading to fat cell reduction and limited fibrosis.
RESULTS : Depressed mood occurred in @percent@ ( 155 / 1085 ) of participants.
RESULTS : Depression and frailty occur in a significant proportion of frail older individuals.
RESULTS : Depression and history of attempted suicide were not associated with neural responses to angry faces , failing to replicate earlier studies.
RESULTS : Depression groups displayed different patterns and levels of health care engagement.
RESULTS : Depression was associated with loneliness in both populations.
RESULTS : Depression was significantly associated with the presence of subcortical Lewy bodies.
RESULTS : Depressive and anxious seniors adopt dysfunctional sleep-related cognitions in higher proportions than asymptomatic older persons.
RESULTS : Depressive symptoms and functionality disability increased over time.
RESULTS : Depressive symptoms and suicidal ideation are the only factors that directly affect suicidal attempts.
RESULTS : Depressive symptoms occurred in @percent@ of the participants.
RESULTS : Depressive symptoms were consistently associated with elder abuse.
RESULTS : Dermatologist assessments revealed a general decrease in severity of roughness , wrinkles , pigmentation , and lentigines during winter compared with summer.
RESULTS : Describing partners ' suffering as interpersonal and using social ( family ) words were associated with higher systolic BP reactivity.
RESULTS : Despite diagnosis of comorbid medical conditions , most participants were admitted for improved functioning or assessment for alternative accommodation.
RESULTS : Despite improvements in body composition during treatment , residual benefits @number@ months later ( week @number@ ) were variable.
RESULTS : Despite the clinically normal-hearing participants , the analysis showed a significant relationship between speech recognition outcome and pure-tone thresholds.
RESULTS : DHEA-S levels were significantly higher on days after ADS use.
RESULTS : Diabetes is a predictor for institutionalization.
RESULTS : Diabetes was more prevalent in men and women who had uncontrolled hypertension than those with controlled hypertension or undiagnosed hypertension.
RESULTS : Diagnosis of depression and antidepressant therapy in residents diagnosed increased at a rapid rate.
Results did not change in those who were > 76 years at baseline or according to functional status.
Results did not differ between these groups.
RESULTS : did not show any significant between-group differences for improvements in muscle strength and power or ROM at any time points.
Results did not vary significantly by CFH genotype in African Americans.
RESULTS : Dietary intake of vitamin K was significantly associated with higher BMD and better QUS.
RESULTS : Differences between group chronological ages ( CA , @number@.47±0.48 to @number@.36±2.44 , mean±SEM ) were controlled with linear regression.
RESULTS : Differences existed in lists of foods most frequently consumed by mealtime and race when comparing results based on original and revised data sets.
RESULTS : Diffuse generalized hair loss was the most common form of scalp hair loss , reported by @percent@ of women.
RESULTS : Diffusivity values revealed statistical changes with age in both midline and lateralized subregions.
RESULTS : Dinucleotides in congenital aniridia patients were higher than in control subjects.
RESULTS : Disability in activities as household tasks , traveling , shopping , and continence had the highest risk and increased rapidly with age.
RESULTS & DISCUSSION : Microwave irradiation using a stop-flow monomodal microwave reactor has been found to facilitate scale-up of the synthesis of VX-745.
RESULTS : Diseases and regularly used medications were more common among the group of aging workers.
RESULTS : DISH was present in @percent@ of men and @percent@ of women.
RESULTS : Disparities in disability by education vary markedly across states-from a @number@ percentage point disparity in Massachusetts to a 12-point disparity in Wyoming.
RESULTS : Dissolution was found to be limited.
RESULTS : Distribution ratios of keratoconic eyes in the three age groups were @percent@ younger , @percent@ middle , and @percent@ older.
RESULTS : Dizziness was reported by @percent@ of participants in the study.
RESULTS : DM2 and non-DM did not differ for age , mean 24-hour BP levels , nighttime BP , albuminuria , and body mass index.
RESULTS : DNA methylation modulated rhythmic expression of clock genes in cultured fibroblasts.
RESULTS : DNA samples were isolated from the lens capsules of @number@ patients , mean age @number@ and screened for L-ferritin mutations.
RESULTS : Donor eyes showed a normal distribution of thicknesses.
RESULTS : Donors ' main reasons for donating were financial payment and wanting to help others.
RESULTS : Drinking speed was quickest for the wide-bore straw , followed by the NBS and slowest for the PSVS.
RESULTS : Drug utilization and adherence rates were high in both groups.
RESULTS : DSI diminishes communication and well-being and can cause social isolation , depression , reduced independence , mortality , and cognitive impairment.
RESULTS : dTGM had a lower physical activity and an increased food intake without change in body weight.
RESULTS : Dual targeting of VEGF and Ang2 achieved effective normalisation at only one-tenth of the dose required with bevacizumab alone.
RESULTS : Duration of disability varied among the four groups.
RESULTS : During a five-year follow-up , @number@ participants developed incident cognitive impairment.
RESULTS : During ageing in vivo , the enzymatic activity of AChE decreases , but not the AChE protein concentration.
RESULTS : During a mean follow up of @number@ ( SD ±4.4 ) years , @number@ participants had heart failure.
RESULTS : During a mean follow-up of @number@ years , @number@ participants died.
RESULTS : During a mean follow up of @number@ years ( SD = 5.2 yr ) , @number@ participants developed atrial fibrillation.
RESULTS : During a mean follow-up of @number@ y , there were @number@ deaths.
RESULTS : During a mean follow-up period of @number@ ± @number@ years , LVRR occurred in @percent@ ( 15 / 44 ) of the patients.
RESULTS : During a mean of @number@ years of follow-up ( SD = @number@ ) , @number@ individuals ( @percent@ ) developed mild cognitive impairment.
RESULTS : During a median follow-up of @number@ months , the cumulative incidence of restricting fatigue was @percent@ for men and @percent@ for women.
RESULTS : During a median follow-up of @number@ years ( 25th to 75th percentile , @number@.2-8.2 ] , @number@ ( @percent@ ) elderly patients died.
RESULTS : During a median follow-up of @number@ years , @number@ cases of incident all-cause dementia were diagnosed , of which @number@ cases were AD.
RESULTS : During a median follow-up of @number@ years , @number@ patients ( @percent@ ) died.
RESULTS : During a median follow-up of @number@ years , the cohort had @number@ CVD events , @number@ transplant failures , and @number@ deaths.
RESULTS : During a median follow-up of @number@ y , @number@ new cases of diabetes occurred.
RESULTS : During a median follow-up time of @number@ years , the prevalence of hypertension increased from @percent@ to @percent@.
RESULTS : During an 8-year period representing @number@ person-years of follow-up , @number@ individuals were newly diagnosed with AF.
RESULTS : During an average follow-up of @number@ years , @number@ adults ( @percent@ ) developed cognitive decline.
RESULTS : During an average follow-up of @number@ years , @number@ participants ( @percent@ ) developed CD.
RESULTS : during an average follow-up of @number@ years , @number@ participants ( @percent@ ) died.
RESULTS : During an average follow-up of @number@ y , @number@ women developed T2D.
RESULTS : During an average of @number@ years follow-up , @number@ deaths occurred with @number@ from cancer.
RESULTS : During complete 5-year follow-up @number@ ( @percent@ ) participants died.
RESULTS : During follow-up ( median @number@ years ) , @number@ subjects developed T2DM.
RESULTS : during follow-up , @number@ falls per @number@ person-years were reported.
RESULTS : During follow-up , @number@ hip fractures were identified in women and @number@ in men.
RESULTS : During follow-up , @number@ individuals developed AD.
RESULTS : During follow-up , @number@ participants developed CVD.
RESULTS : During follow-up , @number@ participants experienced at least one fall.
RESULTS : During follow-up @number@ patients died , @number@ ( @percent@ ) of PCa and @number@ ( @percent@ ) of other causes.
RESULTS : During follow-up , @number@ ( @percent@ ) men died.
RESULTS : During follow-up , @number@ ( @percent@ ) participants died.
RESULTS : During follow-up , @number@ persons developed limitations in walking speed , @number@ in balance , and @number@ in chair stands.
RESULTS : During follow-up , @number@ persons died.
RESULTS : During follow-up , @number@ women and @number@ men developed mobility disability , and @number@ women and @number@ men died.
RESULTS : During follow-up of @number@ years , @number@ of @number@ ( @percent@ ) participants developed impaired mobility.
RESULTS : During median follow-up of @number@ years , there were @number@ incident AF events.
RESULTS : During @number@ @number@ person-years , @number@ participants died , of whom @number@ due to a cardiovascular cause.
RESULTS : During @number@ person-years of follow-up , @number@ subjects developed diabetes.
RESULTS : During @number@ years ( median ) , @number@ deaths occurred.
RESULTS : During @number@ years of follow-up ( 2006-2012 ) , we documented @number@ incident MI cases.
RESULTS : During @number@ years of follow-up , @number@ of @number@ study participants developed primary RKF.
RESULTS : During @number@ years of follow-up , @number@ ( @percent@ ) of the participants died.
RESULTS : During @number@ years of follow-up , @number@ ( @percent@ ) participants died.
RESULTS : During @number@ years of follow-up , @number@ ( @percent@ ) participants died , of whom @number@ died due to cardiovascular diseases.
RESULTS : During rest , all hemodynamic parameters were similar between age groups , apart from blood pressure.
RESULTS : During storage under blood bank conditions , RBCs become increasingly susceptible to loss of phospholipid asymmetry induced by hyperosmotic shock and energy depletion.
RESULTS : During the 48-year follow-up , @number@ men ( @percent@ ) died.
RESULTS : During the 6-year follow-up , @number@ incident cases of T2DM were identified.
RESULTS : During the 9-month follow-up of the rehabilitation program , the employees ' physical capacity was improved.
RESULTS : During the decreasing period of hospitalisation days ( 2001-2004 ) , the reduction of LOS contributed to about @percent@ of the reduction.
RESULTS : During the first night ( no blood sampling ) , sleep was similar in both conditions.
RESULTS : During the follow-up ( median = @number@ years ) , @number@ ( @percent@ ) incident ADL disability events were reported.
RESULTS : During the follow-up , @percent@ reported declines in higher level functional capacity.
RESULTS : During the follow-up period , @number@ individuals developed AD.
RESULTS : During the follow up period , @number@ men developed CHD.
RESULTS : During the follow-up period , @number@ men ( @percent@ ) and @number@ women ( @percent@ ) died.
RESULTS : During the follow-up period of @number@ years ( 1998-2010 ) there were @number@ deaths ( @number@ % ) in the @number@ Cohort Survey.
RESULTS : During the median follow-up of @number@ years , @number@ participants deceased ( @percent@ ) .
RESULTS : During the @number@.5-year follow-up @number@ ( @percent@ ) patients died.
RESULTS : During the @number@ month subjects lost height ( @number@ cm ) and body weight ( @number@ kg ) .
RESULTS : During the @number@ years , @number@ cholecystectomies were performed in Finland , of which @number@ ( @percent@ ) were performed using laparoscopic technique.
RESULTS : During the period 2007-2011 , there were @number@ deaths.
RESULTS : During the study , @number@ patients ( @percent@ ) died.
RESULTS : During the study patients showed significant skin tightening on the lower two-thirds of the face.
RESULTS : During the study period , control participants had @number@ ED visits for ACSCs , for a rate of @number@ visits / person-year.
RESULTS : During the study period , @number@ cases ( male : @percent@ ) of culture-proven TB were identified.
RESULTS : during the study period , @number@ cases of AIDS were reported among people @number@ years of age or over.
RESULTS : During the study period , @number@ consecutive patients were hospitalized with bacteremic pneumococcal pneumonia.
RESULTS : During the study period , @number@ patients , of whom @percent@ were males and @percent@ females , were admitted to our Emergency Department.
RESULTS : During the study period , @number@ ( @percent@ ) NH residents with dementia used at least one DAP each month.
RESULTS : During the study period , @percent@ of patients in the diabetes mellitus cohort and @percent@ in the non-diabetes mellitus cohort died.
RESULTS : During this period , an overall of @number@ suspected homicides occurred , @percent@ being perpetrated against elders.
RESULTS : During this period , only two patients aged over @number@ years were diagnosed with internal carotid artery dissection in our center.
RESULTS : During three years of follow-up , @number@ of @number@ participants died , and the overall all-cause mortality was @percent@.
RESULTS : During treatment , compared with older adults , emerging adults reported more DDD but similar PDA.
RESULTS : D values for human skull caps scatter strongly as a function of age.
RESULTS : dVRS were observed in the BG or WM in every subject.
RESULTS : DXA assessments followed @number@ hospitalizations.
RESULTS : Dye staining was evident to some degree in all specimens.
RESULTS : Dyslipidemic CS had shorter TL than non-dyslipidemic subjects ( 7328±1274 vs 7957±1137 bp , p < 0.05 ) .
RESULTS : Dysphagia was observed in @number@ males ( @percent@ ) and @number@ females ( @percent@ ) .
RESULTS : E2 , E3 , and E4 allele frequencies were found to be @percent@ , @percent@ , and @percent@ , respectively.
RESULTS : Each lumbar T and Z scores in the lead exposure group were lower than the control group.
RESULTS : Each measure of diastolic function was robustly associated with N-terminal pro-brain natriuretic peptide and incident HF or death.
RESULTS : Each of the three domains ( Symptom , Activity , Impact ) of the SGRQ was found to be unidimensionality.
RESULTS : Each patient had a mean ± standard deviation of @number@ ± @number@ health problems.
RESULTS : Each performance measure was socially graded.
RESULTS : E-AP-SM2001 showed potent DPPH radical scavenging activity and SOD-like effects.
RESULTS : Early social relations research , while influential , lacked the combined approach of theoretical grounding and methodological rigor.
RESULTS : Eccentricity effects on latencies and errors were larger for older adults than for younger adults , especially in the hardest search condition.
RESULTS : EC could not have achieved its current level of success without academic-community partnership.
RESULTS : Echocardiographic measurements of myocardial function suggest that patients with AD present with an anticipated diastolic dysfunction.
RESULTS : ECs are generated within β-cells , which also express CB1Rs that are fully functioning when activated by ligands.
RESULTS : Edentate status was associated ( OR @number@ 95%CI @number@.2-9.3 ) with severe cognitive impairment in the fully adjusted model.
RESULTS : Educational attainment and follow-up data were available on @number@ ( @percent@ ) of the participants.
RESULTS : Education level independently predicted Internet adoption behavior.
Results : EE decreased with fasting ( @percent@ ± @percent@ ; P < @number@ ) and increased with overfeeding.
RESULTS : eEF1A2 protein expression was positive in @percent@.
RESULTS : EF impairment , assessed using the clock drawing test , was present in @percent@ of participants.
RESULTS : Eighteen articles were included.
RESULTS : Eighteen out of @number@ potentially eligible studies met our inclusion criteria , with most studies focusing on psychiatric inpatient samples.
RESULTS : Eighteen studies were selected after systematic review , comprising @number@ EA and @number@ age-matched untrained subjects.
RESULTS : Eight focus groups were attended by a homogenous sample of @number@ older people and @number@ offspring / caregivers , with @percent@ born overseas.
RESULTS : Eight hundred and four healthy participants ( @percent@ ) fulfilled the exercise test until voluntary exhaustion.
RESULTS : Eight hundred and sixty-one ( @percent@ ) died by @number@ months.
RESULTS : Eight hundred seventy-two ( @percent@ ) participants had used HRT , and @number@ ( @percent@ ) were current users.
RESULTS : Eight participants were resilient and @number@ were not.
RESULTS : Eight patients ( 83±4.5 years ) participated in the study.
RESULTS : Eight publications met the inclusion criteria.
RESULTS : Eight studies fulfilled our inclusion criteria.
RESULTS : Eight studies ( n = @number@ ) were included in the meta-analysis.
RESULTS : Eight subjects ( age 24-53 years ) completed the study.
RESULTS : Eight trials including @number@ patients investigated the effects of EXD in the treatment of osteoporosis.
RESULTS : Eighty-eight per cent of the participants completed @number@ year assessments.
RESULTS : Eighty-five percent of participants attended at least six of eight sessions.
Results : Eighty-five percent of participants indicated at least one role model.
RESULTS : Eighty-four patients ( mean age @number@ years , @percent@ women ) were recruited.
RESULTS : Eighty-nine percent of patients at the MSMC , and @percent@ of patients at the UTH were extubated in the OR.
RESULTS : Eighty-nine percent of the SDMs thought the decision aid was relevant to their needs.
RESULTS : Eighty participants completed the 12-week trial.
RESULTS : Eighty patients were enrolled in @number@ research centers.
RESULTS : Eighty percent of subjects reported participation restriction in at least one aspect of their life.
RESULTS : Eighty-seven ( @percent@ ) of the @number@ facelift patients examined underwent SMMS , and @number@ additional patients underwent isolated SMMS.
RESULTS : Eighty-seven women ( @percent@ ) completed @number@ months.
RESULTS : Eighty-six patients were included.
RESULTS : Eighty-two patients , mean aged @number@ ± @number@ years , were analysed.
RESULTS : Elderly Ghanaians who had been diagnosed with arthritis , angina , diabetes , and asthma were significantly more likely to be hypertensive.
Results : Elderly participants had significantly higher levels of CRP , tumor necrosis factor , and interleukin @number@ and shorter leukocyte telomere length.
RESULTS : Elderly patients constituted @percent@ of the total population.
RESULTS : Elderly patients could be mobilized with lower total collected CD34 + cells.
RESULTS : Elderly patients had the greatest overall survival ( OS ) with combined surgery , radiation and chemotherapy.
RESULTS : Elderly people approach the Internet and health information technology differently than younger people , but have growing rates of adoption.
RESULTS : Elderly persons presented significantly higher proportions not only of CD28-CD57 + , but also of CD28 + CD57 + cells.
RESULTS : Elderly subjects showed a specifically increased distractibility by happy faces when more attentional resources were available for face processing.
RESULTS : Elective hysterectomy was reported by @percent@ ( n = @number@ ) of participants over an 8-year period.
RESULTS : Elevated copeptin levels were seen in @number@ patients ( @percent@ ) .
RESULTS : Eleven combinations occurred more often and eight less often than expected ( p < @number@ ) .
RESULTS : Eleven CPGs were selected and analyzed from @number@ citations.
RESULTS : Eleven men and @number@ women with a mean age of @number@ years [ 60-87 ] were included in the study.
RESULTS : Eleven physicians completed the SQA pre- and posttest ; all answers were downloaded for analysis.
RESULTS : Eleven publications met inclusion criteria.
RESULTS : Eleven subjects in each group completed the study.
RESULTS : eleven trials were identified involving @number@ subjects.
RESULTS : Emergency medical response services were the preferred response for the majority of medium and high risk calls for both caller types.
RESULTS : Emergency trauma care research is characterized by focus on the timing , sequence , and time sensitivity of disease processes and treatment effects.
RESULTS : Emotional complexity was unrelated to age , but negatively related to feeling closer to death.
Results emphasize the need for customized treatment plans.
RESULTS : EMR was performed in @number@ lesions : @number@ were performed en bloc and @number@ by piecemeal technique.
RESULTS : Encapsulated nucleic acids samples were easily and efficiently recovered from minicapsules.
RESULTS : Endoscopy results were positive in @number@ of @number@ patients ( @percent@ ) .
RESULTS : Enrolled participants had a median age of @number@ years ( range 23-73 ) .
RESULTS : Enrollment body mass index was 49±3 kg / m ( @number@ ) ( X±SE ) .
RESULTS : Epidemiologic studies report a relationship between iERM prevalence , increasing age , and posterior vitreous detachment.
RESULTS : Epigenetic changes are responsible for modifying expression of oncogenes and tumor suppressors.
RESULTS : Episodic memory outcomes of adults with MMC were significantly ( P < .004 ) improved with DHA / EPA supplementation.
RESULTS : EPs were implanted for thoracic and abdominal procedures in @number@ and @number@ cases , respectively.
RESULTS : EQ-5D scores decreased with age , particularly for respondents who were unemployed or retired.
RESULTS : ERMs were observed in @number@ eyes ( @percent@ ) and @number@ eyes ( @percent@ ) were diagnosed as idiopathic ERM.
RESULTS : Eruca sativa Mill. aqueous extract ( @number@ to @number@ mg / mL ) inhibited P-selectin expression and platelet aggregation induced by ADP.
RESULTS : ESEM revealed a 5-factor structure in the NSHAP battery , but with considerable cross-loadings.
RESULTS : ES estimates differed substantially depending on the definition of IIV and the test ( s ) on which IIV was based.
RESULTS : Estimated GFRSCR was similar by HIV serostatus , but eGFRCYSC was lower in HIV-infected men.
RESULTS : Estradiol was significantly and positively correlated with global cognitive function in men only ( r = @number@ p < @number@ ) .
RESULTS : ET and CT significantly increased oxidative capacity and expression of mitochondrial proteins and transcription factors.
RESULTS : European consumers had a very strong belief that eating fish is healthy.
RESULTS : even though children were matched by lexical age , there were differences between GC and RG.
RESULTS : Every wrinkle examined was found above and within ±1 mm of a major lymphatic vessel and its surrounding tube of adipose tissue.
RESULTS : Evidence from prospective and case-control studies suggested that increased blood levels of tocotrienols were associated with favorable cognitive function outcomes.
RESULTS : Evidence of Baastrup disease was found in @number@ patients ( @percent@ ) .
RESULTS : Evidence that anxiety predicted FOF , BC , and OE was tentative.
RESULTS : EVO participants demonstrated similar improvements in mood and self-reported function after @number@ weeks of treatment to PST participants.
RESULTS : Excellent clinical outcomes with complete resolution of pain and other symptoms were obtained in @number@ patients ( @percent@ ) .
RESULTS : Excellent results were found for all parameters in reliability test used by the operator.
RESULTS : Executive dysfunction is a powerful predictor of mortality , frailty and disability.
RESULTS : Existing statistics indicate that unacceptable bias and discrimination are occurring , making trans patients less likely to seek care.
RESULTS : Exosomes were isolated from LNCaP cells by ultracentrifugation , contained PSMA and androgen receptor ( AR ) .
RESULTS : Expected roles of CCs included case management of high-risk patients , transitions of care , and population management.
RESULTS : Experiment @number@ indicated that the older adults learned on the ASRTT and achieved similar performance as young adults when no instructions were given.
RESULTS : Explanatory factory analysis produced two factors.
RESULTS : Exposing NHPs to repeated separation stress resulted in depression-like behaviors ( anhedonia and subordinance ) accompanied by reduced hippocampal neurogenesis.
RESULTS : Ex-POWs had shorter telomeres compared to controls ( Cohen's d = .5 indicating intermediate effect ) .
Results : Expression of AQP4 was associated with advancing age among all individuals ( R2 = @number@ P = @number@ ) .
RESULTS : Expression of LRRK2 in yeast was associated to increased hydrogen peroxide resistance.
RESULTS : ex-smokers and current smokers showed increased odds of locomotor disability , CVD and the combined outcome.
RESULTS : Ex vivo , similar amounts of bone mass fashioned adjacent cross sections.
RESULTS : Factor analyses interpreted in consultation with a panel of community advisers showed no measure was statistically robust.
RESULTS : Factor analysis indicated a one factor structure for disease count was tenable , although cancer did not appear to fit the model.
RESULTS : Factor analysis resulted in one-factor solution and acceptable model fit.
RESULTS : Factor analysis results replicated the two-dimensional structure of the Future Time Perspective Scale.
RESULTS : Factorial analysis resulted in three factors that explained @percent@ of the total variance.
RESULTS : Factors associated with the intellectual elements of the specialties were rated most highly.
RESULTS : Fallers had a shorter step length and slower step velocity than non-fallers.
RESULTS : Falls and fall-related injuries were reported by @number@ ( @percent@ ) and @number@ ( @percent@ ) subjects , respectively.
RESULTS : Family caregivers ' caregiving activities were related to patients ' stages of dementia.
RESULTS : Family companions predominantly facilitated doctor and patient information exchange.
RESULTS : Family members ' experience of decision making and death differed based on the presence or absence of trusting relationships with NH staff.
RESULTS : Fatigability was greater when high and low CD were performed during the fatiguing contraction for the women but not for the men.
RESULTS : Fat mass ( FM ) improved significantly ( pre-test , @percent@ , @number@ post-test , @percent@ , @number@ P < 0.01 ) .
RESULTS : FCGs ' most prevalent sleep disturbance problems were sleep quality problems ( @percent@ ) .
RESULTS : Feelings of loneliness significantly increased during @number@ years of follow-up but showed temporal stability ( reliability coefficient @number@ ) .
RESULTS : Female clinicians reported higher ERA-12 scores ; clinicians ' age expectations decreased with greater years in practice.
RESULTS : Females demonstrated lower functional performance in all motor functions relative to men.
RESULTS : Female sex was predominant ( @number@ @percent@ ) .
RESULTS : Females had greater odds of fear of falling than males.
RESULTS : Females : the DFactor model included @number@ cases ( standard R2 = @number@ ) .
RESULTS : Females with stenosis were significantly heavier and shorter than their counterparts in the control group.
RESULTS : Ferritin values in males reached a steady state by @number@ years and did not increase thereafter.
RESULTS : Fertility was assessed in @number@ tall women ( @number@ treated , @number@ untreated ) who had attempted to conceive.
RESULTS : FEV1 averaged @number@.4%±21.2% , and 6MWD @number@.4%±41.3% of predicted.
RESULTS : Few older adults talked with and initiated a talk with their health-care providers about falls in the follow-up period.
RESULTS : Few respondents achieved all good scores within each of the approaches to successful ageing.
RESULTS : Fifteen articles met the selection criteria.
RESULTS : Fifteen measures were excluded after the first round of scoring and a further @number@ after round two.
RESULTS : Fifteen patients completed the study and were analyzed.
RESULTS : Fifteen patients were included ( mean age = @number@ years , SD = @number@ years ) .
RESULTS : Fifteen percent of beneficiaries sustained at least one sentinel injury.
RESULTS : Fifteen studies assessing BASMF and @number@ studies assessing RASMF were included , comprising @number@ older and @number@ young healthy individuals.
Results : Fifteen studies were included and used the photovoice method , global positioning system tracking plus interview , or go-along interviews.
RESULTS : Fifty-eight subjects were diagnosed with NHAP ( Group A ) and @number@ with other pulmonary disorders ( Group B ) .
RESULTS : Fifty-five patients ( @number@ females and @number@ males ) with a mean age of @number@ years were studied.
RESULTS : Fifty-five percent of men and @percent@ of women reported being sexually active.
RESULTS : Fifty-five percent of the cohort was black.
RESULTS : Fifty high-school students participated in the study , conducted from February through @date@ .
RESULTS : Fifty high school students were enrolled and completed the study.
RESULTS : Fifty-nine patients ( Mean age @number@ ± @number@ years ) met the required length of stay and were included in the study.
RESULTS : Fifty-nine studies were included.
RESULTS : Fifty-one institutionalized elderly ( @number@ ± @number@ years ) were included.
RESULTS : Fifty-one percent of the consulted persons declined life-prolonging surgical measures.
RESULTS : Fifty-seven cases of myelomeningocele were identified along with @number@ controls.
RESULTS : Fifty-seven older people with a mean age of @number@ ± @number@ years old ( range from @number@ to @number@ years ) were included.
RESULTS : Fifty-seven percent of the men survived to age @number@ and @percent@ of the participants at a mean age of @number@ displayed independent aging.
RESULTS : Fifty-seven questionnaires were completed.
RESULTS : Fifty-six survey responses were received ( average age @number@ years , SD = 9.0 ; @percent@ females ) .
RESULTS : Fifty-six variants from @number@ previous publications were evaluated in the meta-analysis.
RESULTS : Fifty-six women were enrolled and @number@ percent were followed beyond reepithelialization.
RESULTS : Fifty staff ( mean @number@ per site ) completed training.
RESULTS : Fifty subjects were recruited in each group.
RESULTS : Fifty-three publications representing @number@ unique web-based interventions were included.
RESULTS : Fifty-two ( @percent@ ) patients had GI lesions.
RESULTS : Fifty-two qualitative , ten quantitative survey , and four mixed-methods studies were included in the final synthesis.
RESULTS : Filial piety was not directly related to depression , but rather worked indirectly through caregiving burden.
RESULTS : FIM score and Barthel Index were @number@ ± @number@ and @number@ ± @number@ respectively , in long-term care elderly.
RESULTS : FIM scores , including FIM gain and efficiency , of elderly patients were significantly lower than those of middle-aged patients.
RESULTS : Finally , @number@ cases were included , @number@ in the treatment group and @number@ in the control.
RESULTS : Financial-based factors were more strongly associated with the direction and magnitude of changing self-payments for dental care than were health factors.
RESULTS : Findings from three recent randomized clinical trials provided the rationale and basic components for implementing the new memory care program.
RESULTS : Findings indicated robust differences in health-spending efficiency.
Results : Findings revealed that men were more likely to access and use ICT than women.
RESULTS : Findings revealed that most participants had heard of elderly suicide , with television news as the main source for their information.
RESULTS : Findings showed high levels of disability in the US with small age-related changes between @number@ and @number@
RESULTS : Findings suggest that emotion-cognitive strategies are less efficient for secondary caregivers ( e.g. drawing on personal or religious beliefs ) .
RESULTS : Findings suggest that infectious disease research publications that explicitly or implicitly incorporate social epidemiological approaches have stagnated in recent years.
RESULTS : First , analyzing mean level age differences , the paradox was confirmed.
RESULTS : First approach : @number@ SNPs were selected based on an overall interaction effect at p < 10-4.
RESULTS : Firstly , results showed a significant improvement in associative learning and verbal recall , as well as significant stereotypes score reduction after treatment.
RESULTS : First , telomere length correlated with chronological donor age ( n = 41 ) .
RESULTS : FISI scores improved in @number@ ( @percent@ ) across all time points among the @number@ women ( @percent@ ) completing the trial.
RESULTS : Fitting linear mixed effect models , we found that hypertension and diabetes react differently with various spatial effects.
RESULTS : Five affected family members were found to have a D187Y substitution in the GSN gene known to cause hereditary amyloidosis type IV.
RESULTS : Five articles were selected from an initial pool of @number@ articles.
RESULTS : Five barrier profiles were identified.
RESULTS : Five eligible RCTs , randomizing @number@ patients in total , were included.
RESULTS : Five eligible studies containing @number@ participants were included in our meta-analysis.
RESULTS : Five focus groups totaling @number@ women with OAB were conducted.
RESULTS : Five groups were identified , each with explicit plans to avoid segregated housing by taking care of each other.
RESULTS : Five hundred and sixteen patients were included in the study.
RESULTS : Five longitudinal studies that examined links between childhood cognition and CVD in adulthood were included.
RESULTS : Five participants ( @percent@ ) of @number@ total did not finish the study.
RESULTS : Five patients were enrolled in this study.
RESULTS : Five publications had the same author and drew from the same population ; these were treated as a single study.
RESULTS : Five research articles , all using cycling TTs , were included , producing @number@ effect estimates and representing @number@ subjects.
RESULTS : Five studies , including eight datasets and @number@ subjects were analyzed.
RESULTS : Five subjects out of @number@ failed to regain weight after two years.
RESULTS : Five subjects received a lower treatment dose and were therefore excluded from analysis.
RESULTS : Five systematic reviews were identified.
RESULTS : Five thousand fifty nine persons ( @percent@ male ) were enrolled with a mean age of @number@ ± @time@ years.
RESULTS : Five thousand six hundred and ninety one elderly were included in the current analysis.
RESULTS : five trials of sufficient quality were included.
RESULTS : Five-year relative survival increased for both CLL and CML in both England and the US between 1996-2000 and 2006-2010.
RESULTS : Five-year relative survival was @percent@ overall in Germany and @percent@ in the US.
RESULTS : FMR1 did not associate with AMH overall.
RESULTS : Following adjustment of sociodemographic characteristics , the misdiagnosed were found to have less severe cognitive and functional impairment.
RESULTS : Following a systematic review , @number@ articles out of @number@ original research articles were selected for this analysis.
RESULTS : Following completion of the 8-week exercise programme , both groups showed significant improvements in global and specific cognitive domains.
RESULTS : Following programming , participants significantly improved strength , flexibility , and balance.
RESULTS : Following skeletal maturation , chondrocyte numbers decline while increasing senescence occurs.
RESULTS : Following TriPollar treatment , a significant increase of glycerol release by skin samples was found.
RESULTS : Follow up data were available for @number@ of the original @number@ participants.
Results Follow-up data were available for @number@ % , of whom @number@ % still had paid work.
RESULTS : Follow-up data were available of @number@ patients.
RESULTS : Follow-up has been completed for @number@ patients ; mean age was @number@ ( ±12.86 ) years and @percent@ were male.
RESULTS : Follow-up ranged from @number@ months to @number@ years , and there have been no major complications.
RESULTS : Follow-up was complete for @number@ patients.
RESULTS : Foot posture showed no association with low back pain.
RESULTS : For AI@75 there was an effect of age ( p < 0.0001 ) , but not training ( p = 0.71 ) .
RESULTS : For all ages and both races , fibers were preferentially oriented equatorially at all layers ( P < @number@ ) .
RESULTS : For all antipsychotics combined , weight change was not associated with persistence.
RESULTS : For all countries , DFLE values decline as age increases for both sexes , with a pronounced decline among women.
RESULTS : For article @number@ a total of @number@ reports were found.
RESULTS : For both age groups , there was robust facilitation by congruent contexts but minimal inhibition by incongruent contexts.
RESULTS : For both groups , ICCs for instrumented standing balance measures were best for spatio-temporal measures , while frequency measures were less reliable.
Results for CAIDE ranged from c-statistics of @number@ ( @number@.427-0.554 ) to @number@ ( @number@.565-0.625 ) .
RESULTS : Forearm muscle CSA was associated with cortical and total metacarpal CSA and polar SSI.
RESULTS : Foreign home care workers ' satisfaction was directly associated with family members ' and care recipients ' satisfaction.
RESULTS : For enamel , higher demineralization around the composite restorations was observed , regardless of dentifrice or aging.
RESULTS : Forgivingness and depression were negatively associated in both residential elderly individuals and community-dwelling elderly individuals.
RESULTS : For healthy adults with Down syndrome there is a gradual increase in thyroxine and possible gradual decline in thyroid-stimulating hormone with age.
RESULTS : For husbands , neither care status nor spouse's disability status are associated with experienced well-being.
RESULTS : For NEC and NYC groups , Glx / Cr and GABA + / Cr ratios were lower in NEC in ACC and rHP.
RESULTS : For our primary analysis , we matched @number@ pairs of statin users and nonusers.
Results : For partnered participants , greater positive affect and life satisfaction was associated with more sexual activity and physical tenderness.
Results for patients with mild but visible midface descent are gratifying.
Results for recurrent fallers were similar.
RESULTS : For standard trials , reported scanning was associated with more table gazes , relative to reported retrieval.
Results for the 10-year follow-up period were similar.
RESULTS : For the eight drugs included , @number@ citations were identified.
RESULTS : For the entire sample , there was a nonsignificant trend toward a negative relationship between DepE and CAMCOG-R scores.
RESULTS : For the factor \ "solution \ " , there was no significant difference among the groups ( p = 0.32 ) .
Results for the MIND diet were similar.
RESULTS : Forty children with CM were studied along with forty age- and sex-matched controls.
RESULTS : Forty-eight participants with adult CHD completed neuropsychological testing.
RESULTS : Forty-five eyes of @number@ subjects , who had no ocular disorders or fundus autofluorescence abnormalities except for age-related nuclear cataract , were included.
RESULTS : Forty-five older and @number@ younger adults ( median age @number@ and @number@ years , respectively ) were studied.
RESULTS : Forty-five studies ( @percent@ of @number@ studies ) reported gender ratios for each subsample and were included.
RESULTS : Forty-four elderly were included ( intervention group : @number@ control group : @number@ ) .
RESULTS : Forty-four patients ( @percent@ ) completed the study.
RESULTS : Forty men ( @percent@ ) and @number@ women ( @percent@ ) died during 6-year follow-up.
RESULTS : Forty-nine participants completed the trial in each group.
RESULTS : Forty of @number@ ( @percent@ ) were classified as NC-low , and @number@ ( @percent@ ) as NC-high.
RESULTS : Forty of @number@ registered patients reported adverse events in the glabellar region.
RESULTS : Forty of the forty-eight residents ( @percent@ ) completed the learner's needs assessment survey.
RESULTS : Forty-one cases were followed up for @number@ to @number@ years.
RESULTS : Forty-one families of children with HIV were enrolled.
RESULTS : Forty-one patients with CD were included.
RESULTS : Forty-one right-sided sleepers and @number@ left-sided sleepers were identified.
RESULTS : Forty-one studies were identified , reporting @number@ multivariate evaluations of the association between a CHADS ( @number@ ) covariate and bleeding risk.
RESULTS : Forty-one studies were meta-analyzed ( N = @number@ mean ± SD age = @number@ ± @number@ years , males = @percent@ ) .
RESULTS : Forty patients ( @number@ % ) transmitted abnormal events via the HM system.
RESULTS : Forty percent of older adults used e-mail or text messaging and @percent@ used the internet.
RESULTS : Forty percent of participants reported a change in sleep duration at baseline.
RESULT ( S ) : Forty percent of women across all age groups expressed concerns about their ability to conceive.
RESULTS : Forty-seven HD carriers and @number@ non-HD controls were enrolled.
RESULTS : Forty-seven older and @number@ younger subjects were included in this analysis.
RESULTS : Forty-seven residents , with a mean age of @number@ years , were presented during the ECHO-AGE pilot period.
RESULTS : Forty-seven subjects ( mean age , @number@.9±1.0 years ; @number@ percent males ) completed the study.
RESULTS : Forty-six full text articles spanning @number@ countries / regions were included in the review.
RESULTS : Forty-six organophosphate poisoning patients were enrolled in this study.
RESULTS : Forty-six patients ( ART group , n = 23 ; control , n = 23 ) were included in the analysis.
RESULTS Forty-six patients in the authors ' institution experienced @number@ late shunt failures in the last @number@ years.
RESULTS : Forty-six subjects aged 14-45years were included : @number@ from tertiary Centers , @number@ from OrSA meetings.
RESULTS : Forty-six women with evaluable voice data at baseline and after intervention were included in the analysis.
RESULTS : Forty-three healthcare professionals ( @number@ from primary care and ten in secondary care ) completed the survey which illuminated national prescribing statistics.
RESULTS : Forty-three patients were included in the clinical analysis , and @number@ from whom spinal cords were obtained were included in the neuropathological analysis.
RESULTS : Forty-two patients had a less than 20-dB change in their pure tone average , with a hearing preservation rate of @percent@.
RESULTS : Forty-two women received ( neo- ) adjuvant chemotherapy.
RESULTS : For upward support from adult children to their parents , children reported that they gave more than their aging parents reported receiving.
Results : Forward and reverse digit spans were similar across groups.
Results found that age was negatively related to participation in voluntary work.
RESULTS : Four acute care topics and @number@ topics in the field of rehabilitation were identified.
RESULTS : Four articles ( three RCT and one single-group pre- and post-test pilot study ) were included.
RESULTS : Four BMI trajectories were identified for men and four for women.
RESULTS : Four clusters were distinguished.
RESULTS : Four factors and the experience of connectedness or disconnectedness within each factor influenced quality of life according to people with dementia.
RESULTS : Four fifths of participants wanted to make decisions independently.
RESULTS : Four groups were identified ; each with distinct characteristics and significantly associated with later disease outcomes.
RESULTS : Four-hundred and five articles were analyzed with @number@ patients.
RESULTS : Four hundred and forty-two respondents returned surveys representing @number@ tribes and consortia.
RESULTS : Four hundred and sixty one participants completed this study.
RESULTS : Four hundred and thirty-six ( @percent@ ) of @number@ participants eligible for the analysis died during the @number@ months of follow-up period.
RESULTS : Four hundred and twenty-two subjects were included in the analysis.
RESULTS : Four hundred fifty-three participants were included in the analyses.
RESULTS : Four hundred five ( @percent@ ) participants reported MD.
RESULTS : Four hundred seventy healthy schoolchildren aged @number@ and @number@ were enrolled.
RESULTS : Four key themes were identified that highlight the role of place in social relationships.
RESULTS : Four overarching themes emerged from the analysis.
RESULTS : Four studies have assessed the primary outcome , two of which reported significant decreases in caregivers ' depressive symptoms.
RESULTS : Fourteen older adults participated in the focus group sessions.
RESULTS : Fourteen participants ( @percent@ ) were classed as having LS.
RESULTS : Fourteen studies met the inclusion criteria.
RESULTS : Fourteen subjects with mild to moderate age-related facial laxity were included in the study.
RESULTS : Fourteen trials with a total of @number@ smokers were included.
RESULTS : Four themes with supporting subthemes emerged : Views on Scholarship ; Locations ; Facilitators and Barriers ; and Visioning the Future.
RESULTS : Four thousand eight hundred and twenty-five participants were recruited ( mean age @number@ ± @number@ years ) .
RESULTS : Fourty-five ( @percent@ ) study subjects had STDE , @number@ at both day and night and @number@ only daytime.
RESULTS : Four weeks after the final treatment sessions , the average wrinkle grades of the treated side were reduced by @percent@.
RESULTS : Four-year decline was evident on measures of orientation , memory , executive function , and language.
RESULTS : Four-year mortality was @percent@ ( n = @number@ ) .
RESULTS : Foveal bulge was present in @number@ ( @percent@ ) and absent in @number@ ( @percent@ ) eyes.
RESULTS : Fracture incidence increased with age among both HIV + and HIV- men.
RESULTS : Frailty is widely recognized as an important risk factor for adverse health outcomes in older persons.
RESULTS : Frailty was highly prevalent ( FP , @percent@ ; FI , @percent@ ) .
RESULTS : Francophone seniors explained their willingness to age-in-place ; however , the lack of services and support in the community makes aging-in-place difficult.
RESULTS : Free cholesterol and LDL / VLDL levels in serum were reduced in groups mimicking estrous cycle and menstrual cycle hormones treatment.
RESULTS : Freedman's method found no between-group differences.
RESULTS : Frequency of CC ( homozygous for the minor allele ) subjects differed among populations ( 1-15% ) .
RESULTS : Frequency of contact did not have a significant influence on psychological distress when contextual factors are controlled.
RESULTS : Frequency of falling was @percent@.
RESULTS : Frequency of malnutrition in the PolSenior population accounted for @percent@ ( in @percent@ men and @percent@ women ; p < 0.001 ) .
RESULTS : From a demographic point of view , male fertility started to decline at 35-39 years of age.
Results from adjusted cohort-specific discovery GWA analyses were meta-analyzed with inverse variance weights ( n = @number@ ) .
Results from aged humans confirmed this positive association of plasma HSP70 and insulin.
RESULTS : From a high initial numerical density and a centripetal distribution of viable osteocytes , the density declined over time.
RESULTS : From all islands , the proportion of males aged 65-80 , 80-90 and > @number@ years was @number@ @number@ and @percent@ , respectively.
Results from clinical assessments indicate that aging signs , such as wrinkling and sagging , are unaffected over such period.
Results from cognitive training studies suggest that despite performance improvement in trained tasks , transfer effects appeared very limited.
Results from computational and numerical modeling studies and mechanical testing of ocular tissue are discussed.
RESULTS : From @date@ to @date@ , @number@ hematological cancer patients were referred for PC ; @number@ elderly AML patients were included into data analysis.
RESULTS : From @date@ to @date@ , @number@ patients were definitely diagnosed as SLE according to both @number@ and @number@ ACR classification criteria.
RESULTS : From exploratory factor analysis , two factors emerged , existential beliefs and perceived control , explaining @number@ % of the total variance.
Results from multivariate regression indicate that ED subjects had significantly lower PCT compared to AD overall and in all quadrants and distances from BMO.
Results from neurophysiological and neuroimaging studies showing that elderly adults are particularly susceptible to the negative effects of pain are of additional concern.
RESULTS : From @number@ case records , @number@ vignettes were abstracted by @number@ trained clinicians.
RESULTS : From @number@ children in the database , @number@ were included in the final analysis.
RESULTS : From @number@ men eligible for analyses , @number@ ( @percent@ ) developed T2DM.
RESULTS : From @number@ non duplicated hits , @number@ studies were included.
RESULTS : From @number@ references screened , @number@ studies were eligible for inclusion.
RESULTS : From @number@ retrieved articles , we screened-out @number@ duplicates and excluded @number@ extraneous articles , leaving @number@ unique articles.
RESULTS : From @number@ studies , @number@ colorectal cancer cases and @number@ controls were included.
RESULTS : From @number@ studies , @number@ meta-analyses and @number@ RCTs were eligible.
RESULTS : From @number@ subjects , @number@ cases were classified as having moderate or severe dementia , and @number@ cases were free of cognitive impairment.
RESULTS : From @number@ through @number@ we reached @number@ older Texas residents.
RESULTS : From @number@ titles , @number@ studies were identified as eligible for inclusion.
RESULTS : From @number@ to @number@ a total of @number@ admissions for PC were registered in Brazil.
Results : From @number@ to @number@ @number@ HIV-infected pregnant women delivered @number@ newborns ( @number@ born to PHIV and @number@ to NPHIV women ) .
RESULTS : From @number@ to @number@ @percent@ of adult depression visits included an SGA.
RESULTS : From @number@ to @number@ physicians reported SA in @percent@ of all office visits in persons aged @number@ and older.
RESULTS : From @number@ to @number@ there was a @percent@ increase in patients utilizing only NPs for primary care.
RESULTS : From @number@ to @number@ we followed @number@ patients for @number@ person-years.
RESULTS : From @number@ years old person to @number@ years , the telomere length becomes shorter during aging.
Results from one laboratory are often difficult to reproduce in another laboratory , leading to confusion.
Results from open field and rotarod tests show A53T mice develop age-dependent changes in locomotor activity and reduced anxiety-like behavior.
Results from our simulation studies show that the thresholds chosen by the proposed stability criteria outperform the Bonferroni threshold.
Results from pooled analyses of all cohorts were consistent with HEALS and BEST.
RESULTS from population studies like ours might increase the available knowledge base when using cats and dogs in clinical environments such as nursing homes.
Results from preclinical experiments are reviewed , including in vitro experiments demonstrating that trigeminal ganglia neurons possess oxytocin receptors and are inhibited by oxytocin.
Results from regression analyses revealed that older age , current financial strain , interpersonal problems , and stress were unique predictors of worse sleep quality.
Results from several studies have shown such latency in response to the nervous system leading to neurodegeneration in old age.
Results from street segment audits along with input from residents can be used to inform sound environmental policies.
Results from structural equation models indicated lower levels of negative affect with advancing age.
Results from studies evaluating BTM are inconclusive.
Results from such study are even more relevant to the clinical scenario when experiments are performed in uremic rats.
Results from the CCF test showed that the deep cervical flexor muscles endurance increased with regular exercise and decreased with aging.
Results from the GELS revealed a fairly even split in the alumni sample of careers in traditional and nontraditional settings.
Results from the initial representative models elicited high degrees of correlation to HU distributions , and regression parameters highlighted physiologically evident differences between subjects.
RESULTS : From the @number@ dry skulls , @number@ presented metopism.
RESULTS : from the @number@ individuals without dementia at the first assessment , @number@ developed dementia at the 2-year follow-up.
RESULTS : From the @number@ patients recruited , @number@ completed the trial per protocol.
RESULTS : From the @number@ retrieved articles , @number@ were included in the review.
Results from the qualitative analysis highlight key areas that contributed to job satisfaction.
Results from the STEP Trials should inform future research and the implementation of interventions to address unhealthy alcohol use among HIV-positive individuals.
Results from the treadmill-walking task showed that the amount of variation in inter-stepping target distance did not differentially affect CWS.
Results from the Western blot and morphology analysis suggested that compounds @number@ and @number@ had the better neuroprotective effects.
Results from this investigation support Tendo as a valid and reliable method for determining muscular power during a STS task among older adults.
Results from this study identify important factors to consider in the design of PHRs so that they meet the needs of middle-aged and older adults.
Results from this systematic review and NMA will enhance decision-making and the efficient allocation of scarce geriatric resources.
Results from two experiments revealed that prior experience with proactive interference ( PI ) diminished PI's effects for both young and older adults.
RESULTS : Frontal DWMH were detected in > 50% of the sample.
RESULTS : FT3 and FT4 levels were negatively associated with age.
RESULTS : FT3 decreases throughout life , significantly more so among females , with equalization between sexes with greater age.
RESULTS : FTS score was associated with several comorbidities and biomarkers classically associated with frailty.
RESULTS : Full MMSE scores can be generated for the abbreviated version by assuming high functioning on excluded items.
RESULTS : Functional decline over a 4- and 8-year period was noted in approximately @percent@ and @percent@ of study participants , respectively.
RESULTS : functional disability in ADL decreased between the cohorts ( @number@ versus @percent@ , P < @number@ ) .
Results : Gait speed was fastest in those with -WMH / -OC and slowest for those with + WMH / + OC.
RESULTS : Gal-3 levels were associated with age and severity of renal dysfunction.
RESULTS : GDM-exposed ECFCs were more proliferative than control ECFCs.
RESULTS : Gender , age , and education differentiated the criteria influencing the decision to purchase functional food.
RESULTS : Gender did not determine mean ACTH concentrations during the saline or cortisol feedback-clamp phases per se.
RESULTS : Gender differences are profound.
RESULTS : Gene expression levels followed different trajectories over the lifespan.
RESULTS : Generalised obesity and abdominal obesity increased among men and women from @number@ to @number@
Results generally show stability in cognition , mood , and physical performance.
RESULTS : Genome-wide methylation levels were measured in whole blood using the Illumina Methylation @number@ array.
RESULTS : Genotype analysis of the mice in L-ORD mouse colony detected the rd8 mutation in the homozygous and heterozygous state.
RESULTS : Genotype frequencies were compared in subjects with low and high NO ( x ) levels.
RESULTS : Geographic region was significantly associated with use of psychotropic medications.
RESULTS : Geriatric assessment , pharmacology , and psychosocial knowledge skills were the three identified areas of educational need.
RESULTS : Geriatric consultation occurred rarely in the perioperative period ( @percent@ ) .
RESULTS : geriatricians have made a significant contribution to the development of integrated care for older people.
RESULTS : Geriatric patients were older ( P < .001 ) and had lower preadmission functional levels ( P < .001 ) than medical patients.
RESULTS : Geriatric syndromes were much more strongly associated with self-care disability than chronic conditions in multivariable models.
RESULTS : Ghrelin was negatively correlated with several cognitive domains , including verbal memory , working memory , and naming.
RESULTS : Gigantol depressed AR gene expression in HLECs.
RESULTS : Glaucoma patients were followed up for a mean of @number@ years ( range , @number@ @date@ years ) .
RESULTS : GLB1 expression accumulates in replicative and induced senescence and correlates with senescent morphology and P16 ( CDKN2 ) expression.
RESULTS : GlcNAc increased the viability of , and inhibited ROS production in , HS68 cells exposed to UVB irradiation.
RESULTS : Global cognitive function was significantly better after 8-wk consumption of flavanone-rich juice than after 8-wk consumption of the low-flavanone control.
RESULTS : Global rather than region-specific structural alterations were revealed in groups of MCI and AD relative to healthy elderly using MANCOVA.
RESULTS : Glucose control was tight in @number@ % and fair in @number@ % of the residents.
RESULTS : glycine was the most abundant amino acid in the saliva.
RESULTS : \ "Good health \ " declined with increasing age with @percent@ of men over @number@ years reporting \ "good health \ ".
RESULTS : Governments in Australia have drawn on World Health Organization ( WHO ) concepts to establish AFC initiatives.
RESULTS : Governments were largely uninvolved in the care and support of older dependent people , leaving families to negotiate a ' journey without maps'.
RESULTS : Greater adherence to the Mediterranean diet was associated with longer telomeres after adjustment for potential confounders.
RESULTS : Greater goal engagement was significantly associated with positive but not negative affect.
RESULTS : Greater number of stressful events was associated with poorer performance on tests of speed and flexibility.
RESULTS : Greater strength and area were protective for mobility disability risk and gait speed decline.
RESULTS : Greater time spent in light intensity activity and lower sedentary times were both associated with lower BMI.
RESULTS : Greater total physical activity was associated with lower adiposity for all adiposity markers in a dose-response manner.
RESULTS : Grief reactions of staff reflected many of the core grief symptoms reported by bereaved family caregivers in a large-scale caregiving study.
RESULTS : Grip strength and strength / height decline with age ; the slope is greater after 40-49 years.
RESULTS : grip strength differed substantially between healthcare settings for both men and women ( P < @number@ ) .
RESULTS : GRN + showed smaller cortical thickness than GRN- in the right orbitofrontal and precentral gyrus and left rostral middle frontal gyrus.
RESULTS : Grossly @percent@ of the participants fell into the criteria for TDS.
RESULTS : Group and individual analyses showed a clear effect of age on P1 morphology and amplitude.
RESULTS : Group differences included significantly higher V-Na amplitude in young adults and shorter Pb latency in older nonsmokers.
RESULTS : Group distribution was : male / female = 14 / 16 for the younger group and @date@ for the older group.
RESULTS : Group E displayed the highest SBS before artificial aging , and no statistical difference was found among the other groups.
RESULTS : Growth was positively related to higher childhood SES.
RESULTS : Guidelines were implemented in @percent@ of cases.
RESULTS : GVD markers , including lipid raft-associated proteins and tau kinases , were detected in RVs.
RESULTS : Hair diameter was found to increase for the first 20-30 years of life , after which it began to decrease.
RESULTS : Half of all cases preferred water.
RESULTS : Half of older internet users ( n = @number@ ) had used online health information and found it was helpful.
RESULTS : Half of participants reported using analgesic medications in the previous @number@ weeks.
RESULTS : Half of the patients had dementia.
RESULTS : hAMSC showed proper mesenchymal stem cells phenotype.
RESULTS : handgrip strength was dependent on age , sex , height and BMI.
RESULTS : Happiness remained stable over time.
Results : Harmonization procedure reduced intercohort variation between testosterone measurements in men of similar ages.
Results have been analyzed in order to define the characteristics of the mechanical properties of young pelvic soft tissues.
Results have been compared with those in the literature in order to understand the similarities and discrepancies between young and old patients.
Results have been disappointing , except for the case of testosterone that have shown some benefits.
Results have been expressed by the ratios of Ct obtained for the two amplification curves.
Results have implications for the design and assessment of training interventions targeted at middle-aged and older adults for complex real-world tasks.
Results have implications for theories of health behavior and indicate further research with larger samples , additional psychosocial influences , and other symptoms.
RESULTS : Having lost a child , spouse or both child and spouse did not predict mortality risk.
RESULTS : HCT1026 was well tolerated and did not cause any measurable toxic effect , whereas flurbiprofen fed mice showed severe gastrointestinal side-effects.
RESULTS : Health literacy was directly associated with sunlight exposure ( β = .20 , p < .01 ) .
RESULTS : Health outcomes at baseline for MOW PN and non-MOW PN were not different , but both were worse than the WN.
RESULTS : Health providers reported several problems in tuberculosis control in ZJG county.
RESULTS : Health-related costs were higher for cases throughout the period.
RESULTS : Healthy behaviors were linked to the onset of functional disability.
RESULTS : Hearing loss was related to relatively poor SRTs , and higher speech intelligibility was associated with lower effort and higher performance ratings.
RESULTS : Hearing was better than predicted at nearly all frequencies in both ears for Lynx and Apache pilots.
RESULTS : Heart attack was significantly more prevalent in oldest old NHW compared with MA , regardless of gender.
RESULTS : Heart rate increased less in response to the upright posture in HF patients versus control subjects ( p = @number@ ) .
RESULTS : Heart rate increased more during the BFR session , whereas stroke volume decreased greater during the BFR session.
RESULTS : Heavy alcohol consumption , hypertension , and diabetes were significantly associated with lower FA or higher MD ( p < @number@ ) .
RESULTS : Height and weight had positive associations with BMD at all sites , although age had negative associations.
RESULTS : Height , weight , and all radiologic parameters were significantly lower in Group @number@ than Group @number@
RESULTS : Here we carry out a molecular investigation of selective pressure variation , specifically focusing on telomere associated genes across placental mammals.
RESULTS : Here we narrowed down the interaction sites between lamin A and Nesprin-2 to aa 403-425 in lamin A and aa 6146-6347 in Nesprin-2.
RESULTS : Here , we report a Japanese individual with neuroaxonal dystrophy associated with compound heterozygous mutations in the PLA2G6 gene.
RESULTS : Here , we report on the impact of single swim sessions on C. elegans physiology.
RESULTS : Here we test whether differences between people's chronological ages and estimated ages , DNA methylation age , predict all-cause mortality in later life.
RESULTS : Heritability estimates for fish and EPA + DHA consumption ranged from @number@ @date@ and @number@ @date@ , respectively.
RESULTS : Heritability estimates indicated a significant genetic component for EEM ( h2 = @number@ SE = @number@ ) .
RESULTS : Heritability of log-neopterin was estimated at @number@ after adjusting for age , gender , and household ( p = 0.03 ) .
RESULTS : hES-RPE showed impaired initial attachment compared to fRPE ; pigmented hES-RPE showed nuclear densities similar to fRPE at day @number@
RESULTS : Hierarchical linear modeling revealed age-related deterioration in HbA1c values that differed by race / ethnicity and income.
RESULTS : High CRP and low 25 ( OH ) D levels were associated with slow gait speed.
RESULTS : High-density lipoprotein cholesterol ( HDL-C ) was associated with better CCS ( β = @number@ p = @number@ ) .
RESULTS : Higher age was associated with a lower AWT Pi10 ( b = @number@ p < @number@ ) .
RESULTS : Higher DBI at years @number@ @number@ and @number@ was consistently associated with poorer function at year @number@
RESULTS : Higher education and younger age were consistently associated with better performance.
RESULTS : Higher levels of CR were associated with higher QoL , after controlling for potential confounders ( Coef.
RESULTS : Higher levels of organizational and intrinsic religiousness were associated with better physical and mental components.
RESULTS : Higher life satisfaction was associated with fewer doctor visits.
RESULTS : Higher midlife BMI was associated with higher risk of incident dementia ( adjusted HR , @percent@ CI @number@ @number@ @date@ ) .
RESULTS : Higher neuroticism traits of VS , impulsivity , anger-hostility , and anxiety were associated with worse treatment response over time.
RESULTS : Higher proportion of elderly reporting health problems was found.
RESULTS : Higher scores of the total IPSM were significantly ( β = @number@ p = @number@ ) related to shorter telomere length.
RESULTS : Higher stroke risk was associated with faster decline in verbal fluency , vocabulary , and global cognition.
RESULTS : Higher TC , higher HDL-C , and lower triglycerides were associated with higher age @number@ cognitive scores in most cognitive domains.
RESULTS : Higher values of both lost access and gained access at baseline were associated with an increased risk for decline at 18-month follow-up.
RESULTS : ' High ' eye contact tapes were found to be ' high ' in PC using both instruments.
RESULTS : high FOF ( Short FES-I ≥11 ) was reported by @percent@.
Results highlight that failing to show the frequently observed decline in anger expression with age may have pernicious health concomitants.
Results highlight the importance of careful test selection when evaluating for mild cognitive impairment in PD.
Results highlight the need for clinicians to be cautious when conducting neuropsychological assessments of older people who express high levels of dementia worry.
Results highlight the potential effect of FITT-C on healthcare use.
Results highlight the strong positive link between health and concurrent , persistent , and diverse CE among African American women.
Results highlight timelier access to assessment with a high proportion of patients being managed in primary care within a person-centred approach to care.
RESULTS : Highly variable between individuals , RPE-AF increases significantly with age.
RESULTS : High mRNA levels were detected for C1q and some inhibitory complement components.
RESULTS : High N was found among @percent@ , low E among @percent@ , and low C among @percent@ of the sample.
RESULTS : High PEP is associated with higher mastery while low PEP is associated with lower mastery , even after controlling for objective economic status.
RESULTS : \ "High-PS spot \ " and perihematoma regions had higher PS than the contralateral regions ( p < @number@ ) .
RESULTS : Hip BMD , CSMI , CSA and SI showed significantly negative correlations with age.
RESULTS : Hippocampal volume was about @percent@ smaller in the Alzheimer's disease group compared to the VaD group , but the difference was not significant.
RESULTS : Hispanics reported greater life satisfaction than non-Hispanic Whites ( p < @number@ ) .
RESULTS : Histologic features commonly associated with LM were common in negative controls from chronically sun-exposed skin.
RESULTS : Histologic sections demonstrated a lipomatous area without defined ligamentous attachments or encapsulations.
RESULTS : HMOX1 transfection induced cytoplasmic vacuolation and the accumulation of PAS + inclusions in cultured astroglia.
RESULTS : H₂O₂ dose-dependently reduced the cell viability of hRPE cells.
RESULTS : H₂O₂ reduced the viability of ARPE-19 cells in a concentration-dependent manner , which was presented as a typical s-shaped curve.
RESULTS : Hospital records of intentional self-harm ( ISH ) were present in @number@ cases per @number@ home care clients.
RESULTS : Hot flush severity persisted through the MT stages and peaked during the late MT stage , diminishing after the second year postmenopause.
RESULTS : HRQL was lower with nearly all exposures of interest.
RESULTS : HRQOL domains are impaired to variable degrees but with similar profiles depending on the cognitive performance level.
RESULTS : HRS adults with higher well-being polygenic scores experienced fewer depressive symptoms during follow-up.
RESULTS : HS was more common in those aged > 90 years ( @percent@ ) compared to younger subjects ( @percent@ ) .
RESULTS : Human cartilage expressed FOXO1 and FOXO3 but not FOXO4 proteins.
RESULTS : Human skull density estimates are widely scattered as a function of age for both sexes.
RESULTS : Humans with or at risk of type @number@ diabetes frequently exhibit insulin resistance along with structural and functional abnormalities of muscular mitochondria.
RESULTS : Hydrocortisone dose was similar between subtypes and during all growth periods.
RESULTS : Hyperglycaemia , when combined with hypoxia , is able to induce mitochondrial DNA damage in human dermal fibroblasts.
RESULTS : Hypertension , incontinence , arthritis , heart conditions , cancer , and diabetes were the most prevalent conditions.
RESULTS : Hypertension increased the risk of cardiovascular disease ( CAVD ) in elderly men approximately 3-fold.
RESULTS : Hypertension prevalence increased from @percent@ in the period 1993-1994 to @percent@ in 2004-2005.
RESULTS : Hypogonadism was found in @number@ patients ( @number@ % ) .
RESULTS : Hyposmia was reported by all laryngectomees and hypogeusia by @percent@ of patients.
RESULTS : ICC for EXE and MXE for the LOS test were excellent ( EPE = @number@ MXE = @number@ ) .
RESULTS : ICT adoption issues were categorized into different perspectives , representing older people , health professionals and management.
RESULTS : Identification by both age groups was above chance for all emotions.
Results identify factors associated with positive behaviour change that health promoters can utilize when targeting the older adult population.
RESULTS : Identity affirmation positively predicted social resources and mental health , and social resources positively predicted mental health.
RESULTS : Identity stigma was significantly related with higher depressive symptomatology and lower psychological HRQOL.
RESULTS : I developed a multi-tissue predictor of age that allows one to estimate the DNA methylation age of most tissues and cell types.
RESULTS : ( i ) Embryo morphology was reduced in presence of a low FMR1 allele ( P = @number@ ) .
RESULTS : IES score showed that there were @percent@ older people suffering from PTSD after falling ( average score @time@ ± @number@ ) .
RESULTS : IGF-I levels were significantly lower in the highest age categories.
RESULTS : IHC demonstrated that both CyPA and CD147 were expressed in both photophobic and exposal parts of normal human skin in all @number@ groups.
RESULTS : IL-17 and ANGPT2 were significantly increased in BPH cases when compared with controls.
RESULTS : IL-1β treatment increased the expression of LRP5 ( but not LRP6 ) via JNK and NF-κB signaling.
RESULTS : ILI resulted in improved PF compared with DSE after @number@ year ( p < @number@ ) and was maintained across time.
Results illustrated that middle-aged subjects showed similar degenerated pattern in gait stability as the older ones in ML direction.
Results illustrate the profound range of functioning in this age group and indicate considerable differences as a function of each dimension.
RESULTS : Images from a total of @number@ patients ( @number@ eyes ) , including @number@ patients with the rare variant , were analyzed.
RESULTS : IMF CSAs along the length of the thigh were similar in both age groups.
RESULTS : Immediate recall was only able to distinguish AD subjects from MCI patients and clinical controls ( p > @number@ ) .
RESULTS : Immigrant seniors had significantly low age- / sex-adjusted odds of hospitalization , compared with Canadian-born seniors ( OR = @number@ ) .
RESULTS : Immune cell frequencies and phenotypes did not vary between the groups.
RESULTS : Immunoblots revealed increased levels of proNGF in AD subjects but not MCI subjects , whereas cognate receptors were unchanged.
RESULTS : Immunohistochemical analysis showed SIRT6 was preferentially expressed in the superficial zone chondrocytes and PCNA-positive cluster-forming chondrocytes in the osteoarthritic cartilage tissue samples.
Results : Impairment in ADLs developed in @percent@ of participants aged @number@ to @number@ years , in whom further functional transitions were common.
RESULTS : Impairments in instrumental activities of daily living were common in this sample of HF patients.
Results implied modulation of activation in the orbitofrontal cortex ( OFC ) due to emotional distractor valence , which marginally correlated with participant age.
RESULTS : Improving facial volume deficits with filler is linked mainly to gel viscoelasticity and cohesivity.
RESULTS : In 1996 / 1997 , @percent@ of the municipalities had SCUs and @percent@ of the beds in Norwegian nursing homes were in SCUs.
RESULTS : In 2008 / 2009 , an estimated @number@ seniors reported that they experienced UI.
RESULTS : In 3T3-L1 preadipocytes , Ad36 , but not E4orf1 , increased MCP1 and TNFα mRNA , in presence of LPS stimulation.
RESULTS : In addition to the BMI SDS at certain ages , the previous BMI SDS during childhood is positively related to adult weight.
RESULTS : In a follow-up of @number@ to @number@ months ( mean @number@ months ) , four seromas occurred.
RESULTS In all cases , the areas of hypoperfusion were found in the middle cerebral artery territories.
RESULTS : In all dimensions of health , examinees from the category Active ageing achieve higher scores , which indicates better health and better functioning.
RESULTS : In all , @number@ articles were identified.
RESULTS : In all , @number@ older adults aged 65 + died by suicide during the follow-up of > 16 million person-years.
RESULTS : In all , @number@ patients entered the phase II study , of whom @number@ and @number@ had complete and partial responses.
RESULTS : In all , @number@ patients ( @number@ men ) were hospitalized for chest trauma in our hospital between @date@ and @date@ .
RESULTS : In all , @number@ patients were enrolled.
RESULTS : In all , @number@ responses were validated.
RESULTS : In all , @number@ subjects were interviewed.
RESULTS : In all patients a Class I molar relationship was achieved.
RESULTS : In all , @percent@ of subjects were normal , @percent@ sarcopenic , @percent@ obese , and @percent@ were SO.
RESULTS : In all , @percent@ of the subjects had hypertension , @percent@ had diabetes , and @percent@ were obese.
RESULTS : In a mixed-effects model , greater hearing impairment was associated with poorer physical functioning.
RESULTS : In a @number@ years old population , an association between subjective cognitive difficulties and poor sleep quality was observed.
RESULTS : In any 5-year duration , 19-28% of unilateral any AMD cases became bilateral and 27-68% of unilateral late AMD became bilateral.
RESULTS : In a total of @number@ participants , during @number@.8years follow-up , @number@ suffered an OP-fracture.
RESULTS : In baseline models , African Americans had larger persistent level of limitations over time.
RESULTS : In biomarker analyses , @number@ DM cases occurred during @number@ person-years.
RESULTS : In both age groups , corrugator supercilii muscle activity was the highest for all six movements.
RESULTS : In both age groups , dual-task processing was speeded up with practice and variability associated with the means was reduced.
RESULTS : In both countries women and rural residents reported more disability.
RESULTS : In both genders , all frailty indicators significantly aggregated into a three-category ordinal latent variable.
RESULTS : In both groups , a seven-factor solution was selected.
RESULTS : In both groups , CoP and VCoP in AP and ML increased in Post1 compared to Pre ( P < 0.001 ) .
RESULTS : In both groups , muscle CSA and FA did not significantly change over time , whereas ADC significantly decreased.
RESULTS : In both groups , @number@ natural deaths occurred during the study period.
RESULTS : In both groups , the networks were characterized by asymmetrically distributed edges ( predominantly in the left hemisphere ) .
RESULTS : In both @number@.5T and 3T RM images and histology , inter-rater reliability was high.
RESULTS : In both samples , low HSC trajectories were the most common.
RESULTS : In both stages of the trial , intervention and control wards were almost similar at baseline for individual patient characteristics.
RESULTS : In boys , growth of T , W and L shows a prepubertal decrease from BA @number@ to @number@ and then accelerates again.
RESULTS : In case of normal aging SST mRNA expression did not alter , but decreased in cancer ( p < @number@ ) .
RESULTS : In child group , Cobb angle in left was @number@ in neutral was @number@ and in right was @number@
RESULTS : In children , EZP was most strongly associated with weight ( r = @number@ ) .
RESULTS : In children , the ratio of eECV to ECV was @number@ ( SD @number@ ) .
RESULTS : incident overall dementia occurred in @number@ of @number@ participants over a mean follow-up period of @number@ years.
RESULTS : Included in the study were @number@ women with a mean age @number@ + or - @number@ years.
RESULTS : Included studies fell into three domains : @number@ ) electroacoustic characteristics , @number@ ) consumer surveys , and @number@ ) outcome evaluations.
RESULTS : Inclusion criteria were met by @number@ patients.
RESULTS : In comparison to the endurance-trained group , the sedentary group exhibited greater BOLD signal changes in response to the breath-hold task.
RESULTS : In contrast to the control group , the physical , cognitive , and combined training groups enhanced their concentration immediately after intervention.
RESULTS : In correlation analysis , age was positively associated with adiponectin in males ( P < @number@ ) , but not in females.
RESULTS : Increased age was associated with significantly more negative longitudinal changes with each ability.
RESULTS : Increased cognitive decline relative to \ "normal \ " aging was evident in CASI IRT at least @number@ years before clinical diagnosis.
RESULTS : Increased level of depressive symptoms was associated with worse velocity , stride , and swing time variability.
RESULTS : Increased Medicare spending was associated with higher white matter hyperintensity volume , presence of cerebral infarcts , and smaller total brain volume.
RESULTS : Increased periostin expression in glomeruli and tubular epithelium in diabetic renal pathology was observed.
RESULTS : Increased prevalence of lipid and lipoprotein abnormalities were observed across menopausal stages.
RESULTS : Increased WMH volume was associated with poorer cognition and higher cognitive and brain reserve were associated with better cognition.
RESULTS : Increases in disability were associated with newly screening for mild and severe depression.
RESULTS : Increasing age and higher day @number@ ( basal ) FSH levels were significantly associated with poorer response to COH.
RESULTS : Increasing the number of cylinder and wall gap elements beyond their nearest neighbors does not change the transverse relaxation rate.
RESULTS : Increasing THV ( suggesting greater regional atrophy ) was associated with lower scores on the LM-correct responses factor.
RESULTS : Incubation with T. arjuna triterpenes increased FGF-2 , TSP-1 , TGF-β and CTGF expression , and VEGF secretion in vitro.
RESULTS : Independent associations of cognitive ability with age , sex , education , and occupational social class were observed.
RESULTS : Independent mobility , visual attention to the switch , and positive facial expressions during the training period were significantly improved.
RESULTS : Independent of the condition , younger women were better at recognizing sadness and anger than older women.
RESULTS : Independent of the covariates , bilingualism was associated with better memory and executive function at baseline.
Results indicate a weak / moderate correlation between neighborhood and household disorder ( r = @number@ ) .
Results indicated age-related increases both in PFC activation magnitudes and in PFC fC with inferotemporal ( IT ) regions.
Results indicated an improvement in frequency and spatial discrimination in the experimental but not the control group.
Results indicated a preservation of visual expertise with age , with larger N170 amplitude for words than for symbols.
Results indicated high satisfaction in students ' expectations of the program , educational experience , and assessment of faculty.
Results indicated little support for the age dedifferentiation hypothesis , with only two of seven cognitive tests showing significant age dedifferentiation.
Results indicated no between-group volumetric differences at baseline.
Results indicated older adults positively experienced the project and found the relationships with their partners meaningful.
Results indicated possible bidirectional coupling between Fine Motor and Speed.
Results indicated significantly lower microstructural integrity in the bilingual group in several WM tracts.
Results indicated small , but robust , increases in mixed emotions with age.
Results indicated that ∼11% of the variance of Index scores was accounted for by these demographic variables , and @percent@ of variance in subtest scores.
Results indicated that aging and surface treatment significantly affected the shear bond strength of repaired samples ( P < @number@ ) .
Results indicated that all factors , except insight into symptoms , were significantly correlated with functional impairment.
Results indicated that all subjects adapted their reaches at a similar rate and to the same extent across the reaching trials.
Results indicated that although age and education affected the score on this test , sex did not.
Results indicated that both older and younger adults had poor medication management skills and high rates of mild cognitive impairment.
Results indicated that brain regions engaged during the task displayed greater reliability across sessions compared to regions that were not utilized by the task.
Results indicated that conscientiousness , neuroticism and executive function were significant predictors of health behavior in age-corrected regression analyses.
Results indicated that depressive symptoms were associated with both fall and fear of falling in old adults.
Results indicated that EC interacted with stress context in predicting cortisol response.
Results indicated that implicit descriptive norm information was associated with implicit PA intention ( p = @number@ Fisher's exact test ) .
Results indicated that increasing age is associated with changes in the functional architecture of the cortico-basal ganglia circuitry.
Results indicated that job design contributed to @percent@ of the variance in generativity and @percent@ of the variance in personal sense of control scores.
Results indicated that keeping the visual-spatial coordinates the same during acquisition resulted in superior retention only for younger adults.
Results indicated that men and women reported similarly high levels of subjective stress in response to both tasks.
Results indicated that only about @percent@ perceived themselves as financially prepared for retirement.
Results indicated that only current activity promoted better postural control while former activity was ineffective.
Results indicated that participants in both age groups experienced significant difficulties in using the PHR to complete routine health management tasks.
Results indicated that patients with AD and a-MCI generated significantly less physical features and semantic biographical knowledge about famous persons than did normal control participants.
Results indicated that @percent@ of participants aged @number@ and older and @percent@ aged @number@ and older reported AT use.
Results indicated that PKCF had antioxidative effect in vivo which significantly improved the activity of SOD and T-AOC and decreased MDA content.
Results indicated that practice and interval effects occur in simulated flight tasks.
Results indicated that self-efficacy and values mediated the relationship between knowledge and pro-environmental behavior.
Results indicated that short conscripts ( < 161.1 cm ) generally had higher survival rates than their tall peers ( ≥ @number@ cm ) .
Results indicated that the first-order full , three-factor model was the best model among all the alternative first-order and second-order models.
Results indicated that the higher the endorsement of the incremental theory , the better the free recall.
Results indicated that the intervention counties agreed more with being able to assist elder adults with a potential mental illness.
Results indicated that the mean proportion of correct trials and longest duration achieved increased across training sessions , confirming the success of the spaced-retrieval intervention.
Results indicated that there was acceptance of the technology as participants adapted to it.
Results indicated that the trajectory of change in brain activation while performing this semantic memory task differed between APOE ε4 carriers and non-carriers.
Results indicated that the younger group was significantly more accurate than the older adults , p < @number@
Results indicated that this task strongly discriminated individuals with healthy aging from those with early-stage DAT.
Results indicated that younger individuals and individuals with a more incoherent self-concept showed higher average negative affect across the study.
Results indicate GVS-induced adaptations were dependent on available visual information.
Results indicate mixed support for the influence of paternal maturity on fathers ' perceptions of costs and rewards.
Results indicate older-person-only households , and older persons with youth , have , generally , less wealth than households with other age compositions.
Results indicate that 60-year-old men in São Paulo in @number@ could expect to live @number@ years and women @number@ years without cognitive impairment.
Results indicate that age-expanded norms will provide a more accurate reflection of the typical performance of older individuals on the RSAT.
Results indicate that a spouse's onset of a severe health condition worsens the mental health of women and the self-reported health of men.
Results indicate that both husbands and wives who become ADL caregivers have more follow-up depressive symptoms than noncaregivers.
Results indicate that compared with continuously married controls , widowed participants experienced a significant decline in positive emotion within @number@ years following loss.
Results indicate that CR mediates a large amount of its effect by downregulating signalling through the TORC1-Sch9 branch.
Results indicate that functional limitations have a broad impact on self-reported social contact among older adults.
Results indicate that greater structural connectivity of the uncinate fasciculus predicts reduced amygdala activation to sad and happy faces.
Results indicate that health knowledge was less important for predicting driving behaviour than health experience.
Results indicate that high-knowledge participants had significantly higher LMI scores at baseline and over time compared to low-knowledge participants.
Results indicate that high percentages of one or more \ "abnormal \ " scores were obtained , irrespective of the cut-off criterion.
Results indicate that individuals over @number@ and those younger than @number@ rehearsed relationship-defining memories most often.
Results indicate that it is necessary to work on improving the status and protection of elderly.
Results indicate that only selected force platform variables are symmetric and repeatable enough so that their use for comparison purposes is appropriate.
Results indicate that participants ( male and female ) have significantly delayed age of acquisition of all three skills.
Results indicate that prolonged loading causes structural skin changes in humans in vivo in PU predilection sites.
Results indicate that scores of scanned images are equivalent or better than digital images of the same ilia.
Results indicate that several aspects of visual exploration of a flat screen display do not generalize to visual exploration in the real world.
Results indicate that the number of articles emphasizing older adults has not substantially increased.
Results indicate that these SNPs are not associated with reading ability in an Australian population.
Results indicate that verbal memory , processing speed and negative symptoms significantly contributed to functional status.
Results indicating that low and moderate income and advancing age predict more frequent chiropractic service are novel.
RESULTS : Individual differences in changes in neurocognitive performance were strongly correlated with individual differences in changes in performance on the everyday tasks.
RESULTS : Individuals in the 20-30 and 30-40 yr groups performed significantly better in all the psychoacoustic measures in comparison to other age groups.
RESULTS : Individuals living in nursing homes consumed meals more often than living at homes , while AD did not have any impact on it.
RESULTS : Individuals reported mixed experiences of the primary and hospital care they received.
RESULTS : Individuals who had made low-lethality attempts displayed an exaggerated preference for immediate rewards compared with nonsuicidal depressed and healthy control subjects.
RESULTS : Individuals with aMCI required significantly more trials to learn the temporal sequence compared with older adults ( p < @number@ ) .
RESULTS : Individuals with BD had shorter TLs but higher CMV IgG levels than controls ( both p < @number@ ) .
RESULTS : Individuals with bvFTD , eoAD or rtFTD laughed less across both contexts of self and partner than the other groups.
RESULTS : Individuals with CLBP had more sleep disturbance than controls.
RESULTS : Individuals with greater engagement in both literacy and visuospatial activities were more likely to have no cognitive impairment than CIND.
RESULTS : Individuals with high TC had lower MMSE scores as well as significantly more NPS and more symptoms of psychosis.
RESULTS : Individuals with IR had a lower eGFR ( @number@ ± @number@ versus @number@ ± @number@ P < @number@ ) .
RESULTS : Individuals with low LINE-1 methylation ( < median ) had a @number@.0-fold ( 95%CI @number@.3-6.9 ) increased incidence of all cancers combined.
RESULTS : Individuals with osteoporosis had poorer cognitive scores ( P < @number@ ) .
RESULTS : Individuals with schizophrenia had higher levels of TNF-α and IL-6 but not IFN-γ than HCs.
RESULTS : Individual tracings showed very high agreement among the four expert tracers ( pairwise Jaccard indices @number@.82-0.87 ) .
RESULTS : In e4 carriers only , subsequently remembered words were linked to increased hippocampal activity.
RESULTS : In elderly patients , total parathyroidectomy was the most used approach.
RESULTS : In Experiment @number@ the authors observed word frequency effects for both foveal and right parafoveal presentation locations.
RESULTS : In Experiment @number@ the older group had significantly higher thresholds on the relative motion displacement and coherent motion tasks than a younger group.
RESULTS : Infection rates among all ethnic groups declined in more recent birth cohorts.
RESULTS : Inferior frontal gyrus activity during the observation of facial expressions increased with age in subjects with autism , but not in control subjects.
RESULTS : In-field organs see less than @percent@ difference in dose between dose estimators.
RESULTS : Informants generally expressed that the questions and response categories were relevant and easy to understand.
RESULTS : information on the pH and transit time along the GI tract , as well as other GI physiology data was collated and summarised.
RESULTS : In general , destination performance was found to be higher for familiar than for unfamiliar faces.
RESULTS : In general , informal caregivers and hospice providers identified similar key factors that facilitated or impeded caregivers ' process in managing medications.
RESULTS : In general , older age was related to less percent fixation duration but not to differential pupil dilation toward the negative image.
RESULTS : In general , participants liked quasi-rich creams less than quasi-light creams.
RESULTS : IN glulisine was well tolerated but failed to have an acute impact on cognition in ApoE4 carriers with AD.
RESULTS : In Group A , pre-operative ASA grade was higher than the other two groups , compared with Group C , p < @number@
RESULTS : In HEK293 cells aldosterone and in mice DOCA significantly decreased KLOTHO gene expression , effects opposed by spironolactone treatment.
RESULTS : Inherited variants in SORCS1 were associated with AD in all datasets ( @number@ < p < @number@ ) .
RESULTS : In HK-2 cells , DDAH1 expression was reduced by aldosterone treatment , and overexpression of DDAH1 significantly attenuated aldosterone-induced EMT.
RESULTS : Initial CASI scores for younger age and more years of formal education were higher than those for older and less education.
RESULTS : Initial fracture forces were higher in the fusion group ( mean : 1388±190 N versus 1211±158 N ) .
RESULTS : Initially , only A2-O + A2 layering showed fluorescence intensity statistically similar to the natural tooth.
RESULTS : Initially the bioimpedance of the wounds was significantly lower than the impedance of the undamaged skin , used as a baseline.
RESULTS : Initial negative nitrogen balance approached equilibrium by day @number@ but remained lower than with the @percent@ protein diet.
RESULTS : Initial pain level evaluated by EMS ( emergency medical service ) was @number@ ( SD = @number@ ) .
RESULTS : In latent class models , persistent pain occurred with other frailty components in patterns consistent with a medical syndrome.
RESULTS : In linear regression models , leptin was strongly associated with indices of both insulin resistance and secretion.
RESULTS : In males and females , decreased brain metabolism with aging is found in bilateral lateral orbital prefrontal and right anterior cingulate cortices.
RESULTS : In middle-aged subjects , BP and handgrip strength were not statistically significantly associated.
RESULTS : In mixed-effects models adjusted for demographics , each s.d.
RESULTS : In msPLSDA analysis , RBC units stored @number@ days or fewer ( irradiated or nonirradiated ) showed similar metabolomic profiles.
RESULTS : In multivariable models , more frequent RTEC consumption was not associated with a cognitive benefit.
RESULTS : In multi-variate modeling , medical tourism was significantly related to being up-to-date with CRC screening.
RESULTS : In @number@ about @number@ new cases of breast cancer were expected in Ligurian women.
RESULTS : In @number@ a random sampling investigation were carried out on both eyes blind and the low vision in Zhejiang Province.
RESULTS : In @number@ cases the visit was conducted in nursing homes.
RESULTS : In @number@ NEDS contained information on @number@ ED visits of older adults , representing an estimated @number@ ED visits.
RESULTS : In @number@ @number@ geriatric outpatients were referred for CGA.
RESULTS : In @number@ @number@ men completed the revised Minnesota Multiphasic Personality Inventory , from which we derived a measure of self-regulation.
RESULTS : In @number@ of @number@ participants the self-measured waist circumference was confirmed as elevated.
RESULTS : In @number@ patients of the CWC who underwent the survey study , OSA had been previously diagnosed in only @percent@.
RESULTS : In @number@ patients ( @percent@ ) polyps were detected.
RESULTS : In @number@ patients , the prevalence of nocturia was @percent@ while nocturia of @number@ or more was @percent@.
RESULTS : In @number@ @percent@ of men and @percent@ of women reported musculoskeletal disorders lasting for six months or more in the SHLC.
RESULTS : In @number@ the @number@ AUGS practicing physicians represented @percent@ of the total physician workforce.
RESULTS : In @number@ there were @number@ treated-and-released ED visits in adults.
RESULTS : In older adults with multimorbidity , the most prevalent conditions were osteoarticular ( @number@.08-67.80% ) and hypertension ( @number@.64-60.03% ) .
RESULTS : In older patients urge and mixed urinary incontinence were the most prevalent type of ( UI ) .
RESULTS : In OP patients plasma t-Hcy , urine deoxypyridinoline and plasma TPx were significantly higher than those in NOP controls.
RESULTS : Inorganic nitrate supplementation did not affect plasma glucose ( P = @number@ ) or insulin ( P = @number@ ) responses.
RESULTS : In O-Un and O-Tr , type II fibres were smaller and contained fewer satellite cells than type I fibres.
RESULTS : In our approach , the base-case analysis showed a favourable pharmacoeconomic profile of ropinirole PR versus ropinirole IR.
RESULTS : In our BLSA II cohort , the prevalence of gout and hyperuricemia were @percent@ and @percent@ , respectively.
RESULTS : In our sample , @number@ ( @percent@ ) had incident stroke.
RESULTS : In patients with AF , frailty was @number@ ± @number@ ( TFI ) .
RESULTS : In @percent@ nigrosome 1was at least unilaterally clearly present.
RESULTS : In @percent@ of subjects , impaired endothelial function was revealed at inclusion in the study.
RESULTS : In @percent@ of the patients , elevated levels of anxiety and depression were found three months after a MI.
RESULTS : In @percent@ of the patients with MCI , progression of symptoms justified the clinical diagnosis of " probable AD".
RESULTS : In @percent@ of the studies , there was only one age group , i.e. , no stratification by age.
RESULTS : In persons aged 55-65 years , @percent@ reported memory complaints after three years of follow-up.
RESULTS : In post-mortem brain samples , THK-5117 bound selectively to neurofibrillary deposits , which differed from the binding target of PiB.
RESULTS : Insight was found to significantly predict depressed mood , anxiety , and apathy even after controlling for global cognition.
RESULTS : Institutionalized elders performance has significantly deteriorated on functional fitness.
RESULTS : In Study @number@ more than @number@ items were recorded and categorized into @number@ different groups.
RESULTS : In subjects of all ages , reflection times were well within systole.
RESULTS : Insulin sensitivity and mitochondrial oxidative capacity were ~31% and ~21% lower in the obese groups than in the lean group.
RESULTS : Insulin sensitivity was different ( p < @number@ ) between the groups ( patients < obese controls < lean controls ) .
RESULTS : Intensive changes of eyeball dimensions progress with age.
RESULTS : Interactions between perceived health status and social activity were statistically significant for almost all social activity / perceived health combinations.
RESULTS : Interdependent self-construal significantly moderated the effect of attention to angry and sad faces on older adults ' real-life social network changes.
RESULTS : Interestingly , interleukin @number@ beta ( IL-1β ) expressing CD14 + monocytes were increased in AD patients compared with controls.
RESULTS : Intergenerational coresidence significantly increases the psychological well-being of the older adults in Vietnam.
RESULTS : Interleukin @number@ receptor antagonist ( IL1RN ) SNPs ( rs419598 , rs315952 and rs9005 ) predicted Kellgren-Lawrence scores independently in each population.
RESULTS : Internal consistency of the ISEL was high ( α = 0.95 ) .
RESULTS : Internal consistency was @number@
RESULTS : Interrater reliability of muscle GSLs was high between examiners ( ICC ≥ @number@ ) and analysts ( ICC ≥ @number@ ) .
RESULTS : Intervention groups did not differ in demographic characteristics , use of support services , or use of healthcare resources at baseline.
RESULTS : Interviews were conducted with @number@ patients and @number@ health care providers.
RESULTS : Intervisit , interexaminer , and interevaluator intraclass correlation coefficients of randomly selected vessel measurements were all greater than @number@
RESULTS : In the ACT , the peak annual number of prescriptions for BPs was observed in @number@
RESULTS : In the analysis of parameters characterizing individual slope curves , results were varied among different age groups.
RESULTS : In the aprismatic enamel group , the longer etching time resulted in slightly , not statistically significantly higher SBS.
RESULTS : In the baseline study , the fall group had significantly lower values of OLS and MSL.
Results in the brain damaged groups did not support the Valence Hypothesis of emotional lateralization but did support the Right Hemisphere Hypothesis of emotional lateralization.
RESULTS : In the buttock , HA was higher in dermis than in epidermis , while tsGAG and tUA were higher in epidermis.
RESULTS : In the company studied @percent@ of employees were workers.
RESULTS : In the course of the @number@ year-follow-up , @percent@ of subjects were defined as occasional users of benzodiazepine and @percent@ as long-term users.
RESULTS : In the cross-sectional analysis , we found widespread decreases of resting-state functional connectivity in patients with PD in comparison to controls.
RESULTS : In the cross-sectional baseline data , univariate analyses revealed significant associations between many of the hormones and quality-of-life scores and self-rated health.
RESULTS : In the default mode network , only the ventral subnetwork negatively correlated with age.
RESULTS : In the degenerated IVD , the expression of MMP-3 , MRI grading and histopathological alterations of the IVD displayed significant correlation.
RESULTS : In the EAD-100 group and in EAD-200 group , the recruitment was stopped at the 14th and 15th patient , respectively.
RESULTS : In the first study SS produced significant increases of the fibrillin and collagen-1 anti-aging biomarkers compared with the untreated skin control.
RESULTS : In the fully adjusted model , continuous analyses demonstrated that overall physical activity counts were @percent@ lower for each year increase in age.
RESULTS : In the last @number@ months , @percent@ of the sample reported caregiving.
RESULTS : In the living subjects , the average biological age was almost the same as the average chronological age.
RESULTS : In the models containing the control variables , functional ability was found to be associated with both physical and mental HRQoL.
RESULTS : In the ≥ @number@ years group ( @percent@ men ) , the median Breslow thickness was @number@ mm and @percent@ was ulcerated.
RESULTS : In the period 2001-2013 , @number@ HZ-related hospitalizations were registered altogether.
RESULTS : In the pharmacogenetics cohort , @number@ ( @percent@ ) had eGFRs < @number@ mL / min / 1.73 m ( @number@ ) .
RESULTS : In the qualitative component the PTs reported @number@ motivators and @number@ barriers for organizing PA in LTCF.
Results : In the sample , @percent@ were nonsuccessful agers , @percent@ RSA-only , @percent@ SSA-only , and @percent@ successful agers.
RESULTS : In the schizophrenia group , mean GAF scores declined from @number@ at month @number@ to @number@ at year @number@
RESULTS : In the Serbian Citation Index , @number@ articles on the topic of the elderly , and @number@ on children were registered.
RESULTS : In the studied group , @percent@ achieved the recommended level of physical activity.
RESULTS : In the studied period , @number@ UBTs were performed and @number@ were positive.
RESULTS : In the study cohort , @number@ @number@ ( @percent@ ) people had collected at least one prescription for an NSAID in @number@
RESULTS : In the study group , girls had higher bone parameter values than boys.
RESULTS : In the systematic review , @number@ of the @number@ studies used the Mini-Nutritional Assessment ( long or short form ) for malnutrition screening.
RESULTS : In the three age group hair samples , the children's group hair samples have the smallest diameter.
Results in the validation sample were comparable , albeit with lower sensitivities.
RESULTS : In this cohort , the number of individuals with HCV increased from @number@ in @number@ to @number@ in @number@
RESULTS : In this cohort , waist circumference , total cholesterol and fat intake significantly improved at the 12-month review.
RESULTS : In this longitudinal analysis , asthma incidence was positively , but not significantly , associated with all exposure metrics , except for PMcoarse.
Results : In this study , incidence of sarcopenia was @percent@ in men at the 2-year follow-up and @percent@ at the 5-year follow-up.
RESULTS : In this study , @number@ patients participated , of whom @number@ patients ( @percent@ ) were aged ≥65 years.
RESULTS : In this study , @percent@ of participants with diabetes had both depressive symptoms and cognitive impairment.
RESULTS : In this study , @percent@ of urban older adults and @percent@ of rural older adults reported satisfaction with their lives.
RESULTS : In this study , we observed a significant increase of plasma levels of TRX80 in old subjects compared with healthy young subjects.
RESULTS : In this twin study , a variation in telomere length in the placental tissue was mainly determined by the common environment.
RESULTS : In total , A. fumigatus was recovered from @number@ HSCT recipients.
RESULTS : In total , @number@ and @number@ valid responses were received in the GEN and CVOL groups , respectively.
RESULTS : In total , @number@ articles were identified in the search.
RESULTS : In total , @number@ cases were identified : @number@ from our present series and @number@ from the literature.
RESULTS : In total , @number@ concepts were elicited during patient interviews.
RESULTS : In total , @number@ elderly adults ( @percent@ ) were included in the present study.
RESULTS : In total , @number@ geriatric patients ( @percent@ ) experienced AKI , and @number@ satisfied the inclusion criteria.
RESULTS : In total , @number@ GPs recruited @number@ participants ( @percent@ females ) .
RESULTS : In total , @number@ individuals were positively screened for RLS resulting in a standardized prevalence rate of @number@.0 / 1000.
RESULTS : In total , @number@ individual symptom or function domains ( latent factors ) were identified , grouped into @number@ broader factors.
RESULTS : In total , @number@ members in the CAS group and @number@ members in the medication group were recruited.
RESULTS : In total , @number@ @number@ patients were studied , of whom @number@ ( @percent@ ) had preoperative IS.
RESULTS : In total , @number@ older people ( @number@ men and @number@ women ) completed the questionnaire ( @percent@ response rate ) .
RESULTS : In total , @number@ older people participated in the study.
RESULTS : In total , @number@ participants had type @number@ diabetes , and @number@ participants were overweight / obese.
RESULTS : In total , @number@ participants of a random sample have already completed the initial evaluation.
RESULTS : In total , @number@ participants ( @percent@ ) completed the study.
RESULTS : In total , @number@ participants ( @percent@ ) had valid Gompertz curve fits.
RESULTS : In total , @number@ participants were assessed at Wave @number@ @number@ at Wave @number@ and @number@ at Wave @number@
RESULTS : In total , @number@ patients had complete NI data and were available for analysis.
RESULTS : In total , @number@ patients were included.
RESULTS : In total , @number@ patients were included for the final analysis , of whom @number@ ( @percent@ ) were evaluated by nephrologists.
Results : In total @number@ patients were included in this analysis.
RESULTS : In total , @number@ patients were randomized ( @number@ to daptomycin ; @number@ to the comparator ) and @number@ patients completed the study.
RESULTS : In total , @number@ procedures were performed.
RESULTS : In total @number@ publications were studied in @number@ in Enschede , the Netherlands.
RESULTS : In total , @number@ referrals were received and @number@ socioeconomically , cognitively , and racially diverse community-dwelling persons with cognitive disorders were enrolled.
RESULTS : In total , @number@ respondents reported having sex in the past five years and answered all knowledge questions.
RESULTS : In total , @number@ subjects comprised our study cohort.
Results : in total , @number@ subjects contributed data to the analysis.
RESULTS : In total , @number@ subjects were included in this analysis , average age 85±6 years , @percent@ women.
RESULTS : In total @number@ trials were analyzed and @number@ trials included.
RESULTS : In total , @number@ women were initially screened for eligibility , but skin samples from only @number@ of these were analysed.
RESULTS : In total , @percent@ of elderly Korean subjects had fear of falling.
RESULTS : In total , @percent@ patients in the aerobic training group and @percent@ patients in the control group completed the intervention period.
RESULTS : In total , study participants had @number@ hospitalizations , @number@ ( @percent@ ) of which were for an ACS condition.
RESULTS : In total , @time@ % and @percent@ of participants had poor and moderate masticatory function , respectively.
RESULTS : In total , we analyzed @number@ patients : @number@ patients with primary diagnosis of ovarian cancer and @number@ patients with relapsed disease.
RESULTS In total , we identified @number@ @number@ autosomal regions with ROHs.
RESULTS : Intra-class correlation coefficients between the two readers ranged from good to excellent ( @number@ to @number@ ) .
RESULTS : Intraclass correlation coefficients ( ICC ) estimating technical reproducibility were high for replicate samples for each collection method.
RESULTS : Intralaboratory variability of measures of pH and ATP were small compared to interlaboratory variability.
RESULTS : IntraMAT content in QF , HM , and AD for the Older group was significantly higher than in the Younger group.
RESULTS : Intraoperative blood pressure and heart rate were more stable with PNBs ( P < 0.001 ) .
RESULTS : Intra-rater and inter-rater measurements for SpIn yielded correlation coefficients of at least @number@
RESULTS : Intrarater reliability for the pre- and post-PMS scores for all @number@ participants was excellent ( intraclass correlational coefficients = @number@ ) .
RESULTS : Intrathyroidal thymic inclusions appeared on US as a hypoechoic area , with regular linear or punctuate internal hyperechoic echoes.
RESULTS : Intriguingly , we have observed a relationship between nanotopography and piezo-stimulated mechanotransduction and possibly see evidence of two differing osteogenic mechanisms at work.
RESULTS : Intubation of @number@ patients became more difficult , in one patient it became easier , and in the remainder did not change.
RESULTS : Intubation was successful in all @number@ patients.
RESULTS : In univariate analysis , symptoms , stage , effusion , surgery , chemotherapy and chemotherapy cycles showed affecting prognosis significantly.
RESULTS : In univariate analysis , systolic and diastolic blood pressure were significantly lower in the dizziness groups.
RESULTS : Invasive and noninvasive transit times were strikingly similar ( median values @number@ versus @number@ ms ) .
RESULTS : Investigator-assessed POL severity was reduced through week @number@ for @number@ U ( p < @number@ ) .
RESULTS : in vitro , all initial results showed nearly @percent@ gap-free margins.
RESULTS : In Vitro test results showed that the HDPE and all HDPE / HA nano-composites do not exhibit any cytotoxicity to WISH cell line.
RESULTS : In WHAS I and II , similar dose-response trends were observed between combined higher IL-6 and CRP levels and lower pulmonary function levels.
RESULTS : Ionizing radiation significantly increased histamine release and cytokine expression by HMC-1 cells.
RESULTS : IPL irradiation resulted in the improvement of cell viability of skin fibroblasts in a dose-dependent manner.
RESULTS : IR directly and / or with their lyses products ( indirect ) causes oxidative stresses to biological systems.
RESULTS : Irrespective of having chronic morbidity , having a partner was associated with better mental health when partners shared a home.
RESULTS : \ "Irritability \ " was the most prevalent , incident and persistent CSDD symptom.
RESULTS : IR was inversely associated with gait speed among the men.
RESULTS : ISD , mu , and tau , but not sigma , increased with age.
RESULTS : Isokinetic muscle strength significantly increased ( P < 0.01 ) with training.
RESULTS : Isonitramine exerted significant inhibitory effect on α-glucosidases but not α-amylase in vitro.
RESULTS : IS was higher in Control vs OW-Untrained and increased significantly following exercise.
RESULTS : Italian regions joined forces through the \ "Progetto Mattone Internazionale \ " of the Ministry of Health developing several national and international collaborations.
RESULTS : Items about assistive device use and help in the last month were robust ( most kappas @number@.7-0.9 ) .
RESULTS : It has been shown that in the organic comorbidity depressive disorders related in most men , between @number@ and @number@ years of age.
RESULTS : It showed that with aging , the muscle mass decreased with the bone mass losing.
RESULTS : It was founded that the frequency , phenotypic characteristics , and number / function of Tregs were altered significantly with aging.
RESULTS : It was found that concurrent arm swing-stepping induced hesitation primarily in Parkinson's disease patients with low fall-related self-efficacy and a fear of falling.
RESULTS : It was found that higher coffee consumption was associated with a small but significant reduction in number of teeth with periodontal bone loss.
RESULTS : it was possible to construct models that predicted which people would begin receiving intensive social care in the coming @number@ months.
RESULTS : It was revealed that the dominant damage pattern shifts from type L to E with aging.
RESULTS : JAD was found to induce expression of major skin proteoglycans and to induce subtle changes in GAG structure.
RESULTS : Keeping the motor coordinates the same during acquisition resulted in superior retention only for younger adults.
RESULTS : Keyword searches in bibliographic databases yielded high average precision ( @percent@ ) but low average sensitivity ( @percent@ ) .
RESULTS : Kidney function , vascular risk factors and cognitive performance were highly stable both in CKD and control patients.
RESULTS : Knee and ankle joint angles were similar between groups ( P > @number@ ) .
RESULTS : Knee replacement resulted in improved performance in almost all the analyzed ADL activities.
RESULTS : Knowledge of osteoporosis did not change significantly.
RESULTS : Knowledge of practitioners ' with regard to the diagnosis and management of dementia was unsatisfactory ( < 50% ) .
RESULTS : KP significantly increased with age , whereas KD tended to decrease.
RESULTS : Kyphoplasty was performed in @number@ patients ( @number@ sacroplasty ) , vertebroplasty in @number@ and intravertebral expanding implants in @number@
RESULTS : Lack of awareness , reluctance , unavailability , and affordability of services were the main reasons for unmet needs for HCBS.
RESULTS : Lacunar infarcts were found in @percent@ and cortical infarcts in 5·9% of the subjects.
RESULTS : Large variation of photoaging occurred within age groups.
RESULTS : LAR was confirmed in @number@ ( @percent@ ) study patients.
RESULTS : Latent growth curve analysis demonstrated increasing disability and variability after age @number@
RESULTS : Latent growth curve models indicated that initial training effects were maintained over @number@ years and amplified by booster sessions.
RESULTS : Latent profile analysis identified two profiles of parental Holocaust-related communication : intrusive and informative.
RESULTS : Laterally , the columella was framed by stratified squamous epithelium , which transitioned to mucosa at the level of the membranous septum.
RESULTS : Lay perception of fall risks was in general concordance with evidence-based research.
RESULTS : LCA revealed eight clusters characterised by distinct cognitive profile and disease severity.
RESULTS : L. chuanxiong increased osteogenic activity in hMSCs and up-regulated BMP-2 and RUNX2 gene expression via the activation of SMAD @date@ and ERK signaling.
RESULTS : Lean tissues decreased in both genders ( p < @number@ ) .
Results led to the conclusion that freeze-dried black and green tea extracts had strong UV absorbance.
Results : LeFort and total colpocleisis are effective procedures for surgical treatment of advanced pelvic organ prolapse with relatively low complication rates.
RESULTS : Leptin levels increased exponentially with increasing BMI.
RESULTS : LERTD demonstrated no reliability.
RESULTS : Less intensive screening history , higher background risk for CRC , and fewer comorbidities were associated with cost-effective screening at older ages.
RESULTS : Less than @percent@ ( n = @number@ ) reported an end-of-life conversation with a physician during the course of routine care.
RESULTS : Less than @percent@ of participants met recommended dietary intakes for vitamin D , calcium , potassium , or magnesium regardless of age.
RESULTS : Levels of preloss and postloss grief were relatively stable from baseline to @number@ months postloss.
RESULTS : Levels of well-being showed a U-shaped relationship with time.
RESULTS : Life expectancy at age @number@ ( LE65 ) increased by @number@ years for women and @number@ years for men from 1980-1985 to 2006-2011.
RESULTS : Life expectancy free of disability was estimated at @number@ years.
RESULTS : Life satisfaction is similar to that of the German age cohort population.
Results likely reflected in changes in habitual physical activity patterns associated with the transition from subsistence agriculture to less economic dependence upon agriculture.
RESULTS : Limited shoulder flexion was found in @number@ patients ( @number@ % ) and limited abduction in @number@ patients ( @number@ % ) .
RESULTS : Linear BMI slope was associated with all outcomes.
RESULTS : Linear mixed models showed that pain and depressive symptoms were associated over the 13-year follow-up : b = @number@ p < @number@
RESULTS : Lipid peroxidation was found in SMCs exposed to hypoxia and in all cell types exposed to oxidative stress.
RESULTS : Literature review showed that RCD definitions varied.
RESULTS : Little variance was explained across models.
RESULTS : Liver uptake was higher than uptake in any other organ but was not blocked by pretreatment with letrozole.
RESULTS : LN enlarged in @number@ of @number@ individuals , often both longitudinally along the nerve and in cross-sectional volume.
RESULTS : LOAD associations nominally differed for @number@ of @number@ variants ; CR1 and APOE variants were significant after Bonferroni correction.
RESULTS : Load of ultra-short telomeres increased closer to the central weight-bearing area and correlated with cartilage degradation in both OA and non-OA samples.
RESULTS : Logistic regression analyses revealed that greater cognitive ability and educational attainment had a protective effect against risk of tooth loss.
RESULTS : Longitudinal models found that wives were more likely than husbands to indicate reductions in burden in the months after placement in an institution.
RESULTS : Longitudinal predictors were depression history ( cognitive trait and repeated episodes ) and quality of partner's care.
RESULTS : Long-term skiers showed more favourable life-style characteristics and a better health status than the general population.
RESULTS : Loss of spouse increased the risk of outpatient psychiatric visits , psychotropic medication and all-cause mortality.
RESULTS : Low concentrations of EPO + IGF-I provided neuroprotection from gp120 in vitro in a synergistic fashion.
RESULTS : Low educational level was associated with poor initial physical and mental functioning.
RESULTS : Lower ABI had a modest independent association with poorer cognitive functioning at baseline ( partial r = @number@ P < @number@ ) .
RESULTS : Lower level mediation analyses were performed.
RESULTS : Lower methylation intensity at F2RL3 was strongly associated with mortality.
RESULTS : Lower SEP across life was associated with higher fat mass and higher android to gynoid fat mass ratio.
RESULTS : Lower social support and greater functional impairment were associated with greater depressive symptoms.
RESULTS : Lower socioeconomic position was associated with more adverse physical , but not psychological , working conditions.
RESULTS : Low SWB was significantly higher in women than in men ( @percent@ versus @percent@ ; p < @number@ ) .
RESULTS : Low testosterone was moderately related to high FG , independent of age and obesity.
RESULTS : LR intervention decreased depressive symptomatology , improved life satisfaction , and increased specific memories.
RESULTS : LRRK2 levels were increased in cases with restricted Lewy bodies , with a @percent@ increase measured in the substantia nigra.
RESULTS : LTL , cortisol and catecholamine levels did not significantly differ between groups.
RESULTS : LTL was inversely associated with age ( r = -0.090 , p < 0.0001 ) .
RESULTS : LUT SEPs demonstrated two positive ( P1 , P2 ) and one negative peak ( N1 ) .
RESULTS : LVMI , myocyte area and CVF were similar in males and females of 1-month-old rats.
Results lying within the first three deciles were considered as incompatible with safe driving capabilities.
RESULTS : Lymphocyte cultures from patients with CHH display growth defects in vitro , which is consistent with an immune deficiency cellular phenotype.
RESULTS : Macular images from the @number@ subjects with a mean age of @number@ years ( range , 47-85 years ) were assessed.
RESULTS : MAC was present in @number@ participants ( @percent@ ) .
RESULTS : MAD showed large variations according to paternal occupation.
RESULTS : Malar thicknesses showed significant increases at the time of the 1-month follow-up appointments ( p < @number@ ) .
RESULTS : Male facial sagging was prominent at the lower eyelid , upper cheek and lower cheek.
RESULTS : Males spent more time doing regular PA but less time walking and working at home than females ( P < @number@ ) .
RESULTS : Male-to-female ratio was 43 : 32 in both groups.
RESULTS : Mandibular growth spurt could be observed in all six different mandibular measurements , but distances from condylion were more informative.
RESULTS : Many analytes showed dynamic changes in concentration requiring at least @number@ age partitions.
RESULTS : Many of the elderly expressed distrust of health service once their functional decline began.
RESULTS : Many of the same barriers to and facilitators of engagement were discussed by both patients and surrogates.
RESULTS : Marital status and gender each have independent effects on subjective health and depressive symptoms.
RESULTS : MAR scores ranged from @number@ to @number@
RESULTS : MAWT was greater in men than in women and increased linearly with age in all the groups and across all the percentiles.
RESULTS : Maximum back extension moment was non-significantly smaller in elders.
Results may be applied in study of endothelial injury caused by excessive stress in situations such as aging , hypertension and atherosclerosis.
Results may indicate crisis competence in sexual minority elders.
RESULTS : MBs were detected in @number@ of the @number@ subjects ( @percent@ ) .
RESULTS : MCI and Alzheimer's patients showed significantly poorer performances in tasks requiring verbal memory of musical excerpts than the healthy participants.
RESULTS : MCI group performed worse than controls in all VF tasks ( p < @number@ ) .
RESULTS : MCI was identified in @number@ ( @percent@ ) of the participants.
Results : MCM8 was sequenced in @number@ POI participants , whereas MCM9 was sequenced in @number@ participants.
RESULTS : Mean age and median MNA-SF scores of the patients were 75±7.6 years and @number@ points ( min-max : 0-14 ) respectively.
Results : Mean age at baseline was @number@ ( SD = @number@ ) years and @percent@ were women.
RESULTS : Mean age at death was @number@ years ( @number@ SD ) .
RESULTS : Mean age at injury increased @number@ years since the 1970s.
RESULTS : Mean age from @number@ ( SD @number@ ) to @number@ years ( SD @number@ ) and women were @percent@ to @percent@.
RESULTS : Mean age @number@ @percent@ women.
RESULTS : Mean age of all participants was @number@ ± @number@ years ( range , @number@ to @number@ years ) .
RESULTS : Mean age of participants was 81±7years and @percent@ were women.
RESULTS : Mean age of participants was @number@
RESULTS : Mean age of participants was @number@ ± @number@ years , @percent@ were female , @percent@ were African American , and @percent@ had hypertension.
RESULTS : Mean age of participants was @number@ ± @number@ years ; @percent@ were men and @percent@ were white.
RESULTS : Mean age of participants was @number@ ( standard deviation , SD @number@ ) years.
RESULTS : Mean age of study participants was @number@ years ( Standard Deviation @number@ ) , @number@ ( @percent@ ) were women.
RESULTS : Mean age of study subjects was @number@ ( ±2.7 ) years.
RESULTS : Mean age of the elderly patients was @number@.1 + / -3.7 years ( range 65-80 years ) .
RESULTS : Mean age of the @number@ healthy participants was @number@ years ( range , 20-59 years ) .
Results : Mean age of the @number@ participants was @number@ ± @time@ .
RESULTS : Mean age of the @number@ patients studied was @number@ years old and @percent@ were men.
RESULTS : Mean age of the @number@ subjects studied was @number@ years.
RESULTS : Mean age of the OS patients was @number@ ± @number@ years.
RESULTS : Mean age of the participants was @number@ years ( SD @number@ ) , and @percent@ were nonwhite.
RESULTS : Mean age of the patients was @number@ ± @number@
RESULTS : Mean age of the patients was @number@ years.
RESULTS : Mean age of the population was @number@ + / - @number@ years , with @percent@ of women.
RESULTS : Mean age of the sample was @number@ years ( SD = @number@ ) .
RESULTS : Mean age of the study participants , of whom approximately @percent@ were men , was @number@ years.
RESULTS : Mean age ( SD ) of participants was @number@ ( @number@ ) years ( range = 72-96 years ) .
RESULTS : Mean age was @number@.4years , and 265 ( @percent@ ) were > 80 years.
RESULTS : Mean age was @number@ at enrollment and @number@ at death.
RESULTS : Mean age was @number@ ± @number@ years.
RESULTS : Mean age was @number@ ± @number@ years.
RESULTS : Mean age was @number@ ± @number@ years ( @percent@ ≥ @number@ years ) .
Results : Mean age was @number@ ± @number@ years , @percent@ were female.
RESULTS : Mean age was @number@ ( range @number@ to @number@ ) , @percent@ female.
RESULTS : Mean age was @number@ ( SD = 6.5 ) years and @percent@ were ≥ @number@ years.
RESULTS : Mean age was @number@ ( SD ± @number@ ) years.
RESULTS : Mean age was @number@ ( SD = @number@ ) years ; most women had low education and acculturation levels.
RESULTS : Mean age was @number@ ( standard deviation @number@ ) years , with a range from @number@ to @number@ and @percent@ were female.
RESULTS : Mean age was @number@ ± @time@ .
RESULTS : Mean age was @number@ women and men differed in body mass index ; @number@ versus @number@ respectively ( p < @number@ ) .
RESULTS : Mean age was @number@ years.
RESULTS : Mean age was @number@ years and BMI @number@.1kg / m ( @number@ ) for both genders.
RESULTS : Mean age was @number@ years , and @percent@ were female.
RESULTS : Mean age was @number@ years , and @percent@ were male.
RESULTS : Mean age was @number@ years , mean length of stay was @number@ days , and mean number of diagnosis per patient was @number@
RESULTS : Mean age was @number@ years ; @percent@ were men , @percent@ were black , and @percent@ had at least a high school education.
RESULTS : Mean age was @number@ years ( range , 22-77 y ) .
RESULTS : Mean age was @number@ years ( SD = @number@ ) , @percent@ were female and @percent@ were white.
RESULTS : Mean age was @number@ years ( SD = @number@ range 80-95 ) and @percent@ of the participants were male.
RESULTS : Mean AMH level was @number@ ranging from @number@ to @number@ ng / ml.
RESULTS : Mean and median serum retinol concentrations ( SRCs ) were @number@ and @number@ microg / l , respectively.
RESULTS : Mean and peak plantar pressure values were similar between the different days of evaluation.
RESULTS : Mean attentional , executive , and memory change Z-scores were @number@ ± @number@ @number@ ± @number@ and @number@ ± @number@ respectively.
RESULTS : Mean baseline levels ±SD for DKK-1 and sclerostin were @number@ ± @number@ and @number@ ± @number@ pmol / l , respectively.
RESULTS : Mean calculated CSFP was @number@ ± @number@ mm Hg and mean SFCT was @number@ ± @number@ μm.
RESULTS : Mean CCT was @number@ μm with an SD of @number@ μm and a range of 415-695 μm.
RESULTS : Mean change in BMD was @number@.6% / year ; @percent@ of participants reported falls , and @percent@ reported recurrent falls.
RESULTS : Mean CSF NfL concentrations were higher in bvFTD , SD , and PNFA than other groups.
RESULTS : Mean diameter of superficial epithelial cells increases with age ( @number@ μm per year ; p < @number@ ) .
RESULTS : Mean ear temperature was @number@ ± @number@.6°C overall and in the child and adult groups.
RESULTS : Mean EA was @number@.8±16% ( range : @date@ @percent@ ) and there were no differences by sex.
RESULTS : Mean education was @number@ ± @number@ years.
RESULTS : mean energy and macronutrient intake were consistent with dietary guidelines at both time points.
RESULTS : Mean epithelial thickness at the central cornea was @number@ ± @number@ μm.
RESULTS : Mean filler volume was @number@ mL for the Artiste-treated NLF and @number@ mL for manually treated NLF.
RESULTS : Mean FI was @number@ ± @number@ ( range @date@ ) was highest in the oldest group.
RESULTS : Mean follicular phase LH , FSH , E2 and AMH levels did not significantly differ between young women born SGA and AGA.
RESULTS : Mean follow-up was @number@ ( @number@ ) years.
RESULTS : Mean follow-up was @number@ ( SD @number@ ) years.
RESULTS : Mean follow-up was @number@ years ( range 0-9 years ) .
RESULTS : Mean fruit and vegetable consumption was @number@ ± @number@ g / day.
RESULTS : Mean gain was @number@ ± @number@ and there were no differences between sexes.
RESULTS : Mean hearing threshold decreased from preoperatively @number@ to @number@ dB @number@ months after canaloplasty.
RESULTS : Mean HR at rest was higher in women than in men ( p = @number@ ) .
RESULTS : Mean HRmax values were found to decrease at a faster rate in women than in men with age increase.
RESULTS : Mean IGF-I and IGF-II concentrations were lower at 60-64 than at @number@ years , by @percent@ for IGF-I and by @percent@ for IGF-II.
RESULTS : Mean investigator satisfaction was @number@ ( range @number@.7-9.5 ) at @number@ weeks and @number@ ( range @number@.4-9.8 ) at @number@ weeks.
RESULTS : Mean monthly WTP per capita for health insurance amounted to €260.
RESULTS : Mean negative mood scores reduced significantly between @number@ and @number@ as did mean CESD scores between @number@ and @number@
RESULTS : Mean Numerical Rating Scale and Oswestry Disability Index were @number@ and @percent@ , respectively.
RESULTS : Mean patient age was @number@ years.
RESULTS : Mean plasma bioavailable estradiol ( E2 ) levels in the two groups ranged between @number@ and @number@ pmol / l.
RESULTS : Mean retention values ranged from @number@ to @number@ MPa.
RESULTS : Mean RNFL thickness was @number@ ± @number@ µm in @number@ and @number@ ± @number@ µm in @number@
RESULTS : Mean ( ± SD ) anteroposterior and transverse appendiceal diameters were @number@ ± @number@ and @number@ ± @number@ mm , respectively.
RESULTS : Mean ( SD ) baseline age was @number@ ( @number@ ) years ( range , 66-81 years ) .
RESULTS : Mean ( SD ) patient age was @number@ ( @number@ ) years ( range , 31-73 years ) .
RESULTS : Mean ( ±SD ) scores for participants were @number@ ± @number@ for the MedDiet and @number@ ± @number@ for the HEI-2005.
RESULTS : Mean self-reported sitting time was 285min / day for males and 281min / day for females.
RESULTS : Mean serum 25 ( OH ) D level was @number@ ± @number@ ng / ml.
RESULTS : Mean serum sclerostin was @number@ pmol / l and was greater in men than in women ( P < @number@ ) .
RESULTS : Mean serum uric acid level was @number@ mg / dL.
RESULTS : Mean SIF concentrations were @number@.495mumol / l in men and @number@.457mumol / l in women.
RESULTS : Mean skin AF at baseline was @number@ ±0.68 AU and @percent@ participants were frail.
RESULTS : Mean SSA , ST , and C7 translation ratio were respectively @number@.4° ± @number@.1° , @number@.8° ± @number@.4° , and @number@.1° ± @number@.9°.
RESULTS : Mean ± standard deviation ( SD ) BMD was @number@ ± @number@ g / cm ( @number@ ) .
RESULTS : Mean steps / day were @number@ ( 991-17 , 156 ) and @percent@ reported < @number@ steps / day.
RESULTS : Mean sUA concentration was lower in women than in men and increased with age.
RESULTS : Mean systolic and diastolic blood pressure values of the study subjects were @number@ and @number@ mm Hg , respectively.
RESULTS : Mean temperatures of @number@ and @number@.2°C were reported for the infrared camera and infrared thermometer.
RESULTS : Mean time under observation was @number@ years.
Results : Mean total testosterone levels increased in the testosterone group of both trials.
RESULTS : Mean treatment duration was @number@.9 + / -16.1 months.
RESULTS : Mean urinary IL-8 levels almost doubled during and after a @number@ hS compared with a @number@ hS or a control day.
RESULTS : Mean values of cervical AP and TS were @number@ mm and @time@ mm , respectively.
RESULTS : Mean visual acuity was 20 / 100 ( range , 20 / 40 to 20 / 400 ) .
RESULTS : Mean WSRS improved significantly ( P < 0.001 ) by @number@ score points without any decline throughout the 12-week period.
RESULTS : Measures of word-list position-namely , serial position scores-together with Short Delay Free Recall of word-list learning best predicted conversion to AD dementia.
RESULTS : Meat was always the food with the largest amount of AGEs.
RESULTS : Median age among cases was @number@ years , and @number@ cases were classified MSI-high ( @percent@ ) .
RESULTS : Median age of patients and controls was @number@ and @number@ years , respectively.
RESULTS : Median age was @number@ ( 49-80 ) years.
RESULTS : Median age was @number@ ( range : 34-88 ) years at onset of AS.
RESULTS : Median age was @number@ years , @percent@ were Caucasian , @percent@ received antiretroviral therapy and @percent@ had undetectable viral load.
RESULTS : Median age was @number@ years ( range 18-91 , N = 499 ) ; more than half had a final diagnosis of cancer.
RESULTS : Median baseline age was @number@ ( 70-102 ) , median follow-up was @number@ years.
RESULTS : Median CRP concentration was @number@ mg / l.
RESULTS : Median follow-up time ( @number@ days for breast and @number@ days for cervical screening abnormalities ) compared favorably to external benchmarks.
Results : Median follow-up time was @number@ years.
RESULTS : Median growth hormone peak was @number@ μg / L and median cortisol peak was @number@ μg / dL.
RESULTS : Median relative total protein intake was @number@ g / kg body weight in men and @number@ g / kg body weight in women.
RESULTS : Mediation analysis followed guidelines proposed by Baron and Kenny.
RESULTS : Medication preparation and administration were observed for @number@ administrations during @number@ passes for @number@ residents.
RESULTS : Mediterranean diet and Mediterranean diet supplemented with Coenzyme Q10diets downregulated Gadd45a protein levels compared with the saturated fatty acid-rich diet.
RESULTS : Melatonin oral treatment significantly reversed the increased serum LPO level in former-smokers already after @number@ weeks of treatment.
RESULTS : Memory-trained participants showed higher verbatim recall than non-memory-trained participants.
RESULTS : Men and women having at least one child experienced lower death risks than childless men and women.
RESULTS : Men consumed @number@ g of protein / day more than women ( P < @number@ ) .
RESULTS : Men had more impaired cognitive scores on 3MS , MMSE , HVOT , and Trails A ( P < @number@ ) at baseline.
RESULTS : Men outperformed never users in task switching and updating.
RESULTS : Men's narratives demonstrate that an osteoporosis diagnosis is accompanied by negative psychosocial sequelae in this population.
RESULTS : Mental and physical loads were heavily perceived in shift healthcare workers ( p = 0.01 ; p = 0.02 ) .
RESULTS : Mental health service use was more likely for older adults with comorbid general medical illness than for those without it.
RESULTS : Men who reported having experienced adverse childhood experiences reported more depressive symptoms and lower quality of life than their counterparts.
RESULTS : Metabolic syndrome , defined by the criteria of the International Diabetes Federation , was determined in @percent@ of men and @percent@ of women.
RESULTS : metabolic syndrome diagnosis was observed in @percent@ of the sample.
RESULTS : Metatarsal head resurfacing was performed on @number@ patients.
RESULTS : MetS was not associated with cognitive function at baseline or cognitive change over time.
RESULTS : MetS was present in @number@ of @number@ males ( @percent@ ) and @number@ of @number@ females ( @percent@ ) .
RESULTS : Microarray assays revealed that the genetic profile of cord blood and adult ECFC differed in about @percent@ of examined genes.
RESULTS : Microcracks accumulated continuously and extensively in the human otic capsule throughout life.
RESULTS : Microinfarcts and cerebral amyloid angiopathy were not observed within the spinal cord parenchyma.
RESULTS : Microtensile bond strength to eroded dentin was always significantly lower than that to normal dentin.
RESULTS : Microvascular and macrovascular complications were found in @number@ % and @number@ of study population.
RESULTS : Middle-aged war veterans with current PTSD had shorter PBMC telomere length than their age-matched healthy controls while the elderly had the shortest telomeres.
RESULTS : Midpupil lid distances decreased in all angles with advancing age.
RESULTS might be applicable to other structurally similar agriculture regions and to craft sector.
RESULTS : Migraine headaches were found to have no effect on any of the cognitive measures.
Results Mild Alzheimer's disease presented a higher prevalence of apolipoprotein E allele ɛ4 in relation to amnestic mild cognitive impairment and control group.
RESULTS : Mild atrophy of the left hippocampus was associated with less-than-optimal ratings in lane control but not with other discrete driving skills.
RESULTS : Mild-severe depression scores were frequent ( @percent@ ) as well as high perceived stress ( @percent@ ) .
RESULTS : Missing item responses took up @number@.0%-2.7% in the scale.
RESULTS : Mitochondrial dysfunction or injury was demonstrated in different eye tissue of glaucoma.
RESULTS : Mitochondrial dysfunction was induced by treatment with oligomycin , which significantly decreased mitochondrial membrane potential ( ΔΨm ) .
RESULTS : Mixed effects analysis revealed a significant group × time interaction , F ( @number@ @number@ ) = @number@ p = @number@
RESULTS : Mixed-effects model analyses revealed that PATH was more efficacious than ST in reducing depression and disability at @number@ weeks.
RESULTS : Mixed-effects modeling revealed significant effects for the Processing Speed and Verbal Ability domains.
RESULTS : MMP-1 activity and protein level were increased by UVA , which was downregulated by CK.
RESULTS : MNA scores revealed that @percent@ of the subjects were at risk for malnutrition ( @number@ to @number@ points ) .
RESULTS : MOD and BOD specifically inhibited PMA-induced MMP-9 expression as well as invasive and migration potential via ICAM-1.
RESULTS : Model comparisons indicated dynamic coupling relationships between Balance and Fine Motor factors and the Speed cognitive factor.
RESULTS : Model fit indices confirmed that the optimal number of trajectories were between @number@ and @number@
RESULTS : Model @number@ ( n = @number@ ) assessed the prescription of any adjuvant regimen ( hormonal or chemotherapy ) .
RESULTS : Model @number@ showed @percent@ lower mortality in successful agers compared with typical agers and also a @percent@ lower conversion rate to MCI.
Results modestly suggest that nonadditive genetic variance may become increasingly important with age , especially for verbal ability.
RESULTS : Molecular analysis identified altered gene , microRNA , and protein expression in HOXA9 / Meis1 leukemic bone marrow compared to normal controls.
RESULTS : Monocytes from aged individuals were able to differentiate into LCs.
RESULTS : More people achieved their energy and protein requirements with the supplement drink intervention with no sufficient impact on habitual food consumption.
RESULTS : More positive self-perceptions of ageing were related to better self-rated health over a @number@.5-year period controlling for confounding variables.
RESULTS : More than half of all drivers reported at least one driving self-restriction.
RESULTS : More than @percent@ of subjects reported the presence of one or more common morbidities.
RESULTS : More than two-thirds of the elderly ( @percent@ ) had at least one migrant child.
RESULTS : More women reported poor overall HRQOL than men ( @number@ vs. @percent@ respectively ) .
RESULTS : Morphology , chemiluminescence , fluorescence immunohistochemistry , and western blot showed that the epididymal sperm of naturally aged rats had intact plasma membranes.
RESULTS : Mortality after @number@ months was @percent@ overall , with no significant difference between the two groups.
RESULTS : Most caregivers had stable levels of internal resources ( between @number@ and @percent@ showed an increase or decrease ) .
RESULTS : Most CIs aim to increase community participation , while addressing social isolation and poverty.
RESULTS : Most individuals ( n = @number@ @percent@ ) participated in at least @percent@ of the telehealth sessions.
RESULTS : Most interventions involved optimising independence in personal care and mobility.
RESULTS : Most of population showed a very high adherence to the Mediterranean diet pattern and optimal cognitive and affective status.
RESULTS : Most of the benefit measures revealed that the participants obtained significant improvement with their hearing aids.
RESULTS : Most of the mechanical and temporal parameters were influenced by the STS condition ( p < @number@ ) .
RESULTS : most of the sample ( @percent@ ) described themselves as drivers who drove daily or weekly.
RESULTS : Most of the subjects had an untreated component of metabolic syndrome.
RESULTS : Most of the subjects were women ( @percent@ ) .
RESULTS : Most participants ( 77-83% ) preferred including religion and / or spirituality in therapy for anxiety and depression.
RESULTS : Most participants ( @percent@ ) consented to biomarker testing.
RESULTS : Most participants ( @percent@ ) remained in their initial group , but shifts between categories did occur in both directions.
RESULTS : Most participants reported to use memory strategies to take correctly their medication.
RESULTS : Most participants showed stable alcohol-consumption patterns over @number@ years.
RESULTS : Most patients endorsed alcohol use , but frequency was low.
RESULTS : Most patients presented with severe CO-GHD ( @percent@ ) associated with other pituitary deficits ( @percent@ ) .
RESULTS : Most patients were elderly women ( @percent@ ) , mean age±SD was @number@.9±8.8 years.
RESULTS : Most patients were unable to recall their drug regimens or their medical conditions.
RESULTS : most reasons for consultation were those corresponding to lower gastrointestinal tract , followed by liver disease and upper gastrointestinal tract.
RESULTS : Most respondents ( @number@ @percent@ ) were aged @number@ years and older.
RESULTS : Most smokers did not meet the criteria for DSM 12-month ND.
RESULTS : Most track and field events show a linear decline to @number@ years.
RESULTS : Most women performed below criterion-referenced fitness standards for all measures.
RESULTS : Most women were aged 60-69 ( @number@ % ) .
RESULTS : Most women with tuberculosis lived in cities ( @percent@ ) , @percent@ of the evaluated patients lived in villages and @percent@ were homeless.
RESULTS : Mouse cartilage tissue and a human chondrocyte cell line were found to contain intrinsic molecular circadian clocks.
RESULTS : MOVES ranged from @number@ to @number@ where @number@ represents individuals who are immobile and @number@ those who are fully mobile.
RESULTS : MPOD at @number@.5° and @number@.0° between pairs and within single eyes was strongly correlated ( P < @number@ ) .
RESULTS : MP optical density was significantly ( P < @number@ ) related to reaction time and to balance ability for the older subjects.
RESULTS : MRI-PC diastolic parameters were reproducible as reflected by low coefficients of variations ( ranged between @number@ to @number@ % ) .
RESULTS : MR was deeper and wider in the abdomen than in the medial side of the forearm.
RESULTS : MSM who socialized in neighborhoods with more economic deprivation and greater general neighborhood attachment experienced higher GAD symptoms.
RESULTS : MS was found in @percent@ of patients.
RESULTS : MS was more prevalent in CHH ( P < 0.001 ) according to healthy controls.
RESULTS : mtDNA had a significant association with 6-month GOS ( p = 0.008 ) .
RESULTS : MTHFR subgroups ( wild and A1298C single polymorphism ) were not different for age , gender , dietary profile and BMI.
RESULTS : Multigroup confirmatory factor analyses were conducted , yielding a final model with excellent fit to the data.
RESULTS : Multilevel longitudinal analyses revealed linear and quadratic change trends for self-reported IADL function , with steeper declines at higher ages.
RESULTS : Multilevel longitudinal models found that caregivers showed poorer well-being at @number@ months poststroke than controls on all measures except physical health QOL.
RESULTS : Multilevel mixed modeling analyses revealed that greater EA predicted greater suppression and avoidance only among women with higher attentional capacity.
RESULTS : Multilevel models revealed White middle-aged adults provided more support to grown children than Black middle-aged adults.
RESULTS : Multimodal analyses will provide insight into AD pathophysiology and disease progression.
RESULTS : Multimorbidity was indeed related to subjective memory complaints.
RESULTS : Multiple adjusted linear regression analyses demonstrated that all components of logarithmic HOAs increase with age.
RESULTS : Multiple disease clusters were associated with cognition during a 12-year follow-up period in a healthy adult population.
RESULTS : Multiple linear regressions showed that neuroticism and extraversion were significant regression predictors of self-rated health , after controlling for demographic factors.
RESULTS : Multiple regression analyses showed that @percent@ of the variance in ST ( P < @number@ ) could be predicted.
RESULTS : Multiple regression analysis revealed that a younger subjective age at baseline was prospectively associated with better episodic memory and executive function.
RESULTS : Multivariable linear regressions adjusting for age revealed that Trauma , regardless of Depression , is associated with worse VERBAL-LMR performance.
RESULTS : Municipalities with high expulsion or reception rates experienced a slower epidemiological transition , with lower mean ages and aging indices.
RESULTS : Muscle attenuation of the rectus femoris muscle was significantly reduced following the initiation of ADT by @percent@ ( P < @number@ ) .
RESULTS : Muscle biopsy was successfully carried out in @number@ out of @number@ participants , mean yield @number@ mg ( range 20-290 mg ) .
RESULTS : Muscle force trainees were able to undertake training , progressing towards more strenuous exercises.
RESULTS : Muscle samples from newborn , juvenile , and adult Weddell seals were collected during an Antarctic expedition.
RESULTS : Muscle samples were compared between adult ( @number@ years ) and old ( @number@ years ) post-menopausal women.
RESULTS : Muscle strength in subjects in their 70s was significantly lower than that in subjects in their 60s in both sexes.
RESULTS : : Musculoskeletal impairments accounted for more than one-third of all perceived causes.
RESULTS : NAFLD developed after PD in @number@ ( @percent@ ) patients in our cohort.
RESULTS : NAFLD prevalence was @percent@.
RESULTS : Nasolabial fold improved by at least one grade in @number@ percent and by over one grade in @number@ percent.
RESULTS : Natural logarithm ( Ln ) transformation was applied to all HRV parameters.
RESULTS : Natural menopause occurred in @number@ women.
RESULTS : Nearly a third ( @percent@ ) of the young adults had an enrollment lapse.
RESULTS : nearly half , @number@ percent ( n = 45 ) of subjects , reported onset by day @number@
RESULTS : Nearly half of the administrators reported difficulty hiring U.S.-born job applicants.
RESULTS : Nearly half of the sample ( @percent@ ) had either marginal ( @percent@ ) or low health literacy ( @percent@ ) .
RESULTS : Nearly @number@ % of the participants reported they did not take calcium or vitamin D supplements or any specific osteoporosis drugs.
RESULTS : Nearly @percent@ of analyzed women were in the first-time-diagnosed dyslipidemic state.
RESULTS : Nearly @percent@ of participants lost weight and over @percent@ gained @number@ kg or more in midlife.
RESULTS : Nearly @percent@ , @percent@ , and @percent@ of participants had a western , traditional , and healthy dietary pattern , respectively.
RESULTS : Neck scans of @number@ males and @number@ females were reviewed.
RESULTS : Negative feeling scores such as tension-anxiety , anger-hostility , and confusion significantly improved after walking.
RESULTS : Negative priming was present in all age groups.
RESULTS : Negative , stable implicit attitudes towards older workers emerged in two studies.
RESULTS : Neither age group , gender , trial , nor their interactions was statistically significant ( P > 0.05 ) .
Results : Neither low or high body mass index , nor low or high WC , were associated with incident mobility disability.
RESULTS : Neither type of preliminary mechanical damage significantly affected the load-bearing capacity of FDPs.
RESULTS : Nerve impairments were detected in @percent@ of participants , and @percent@ developed mobility disability.
RESULTS : Neurogenesis in the subgranular zone of dentate gyrus was increased in BRINP1-KO mice creating a more immature neuronal population in granule cell layer.
Results : Neurons , but not neuroglia , and blood vessels undergo cellular senescence in the old-age human retina.
RESULTS : Neuroticism and type of illness played a major role in explaining caring burden and mental health.
RESULTS : Neuroticism , depression , anxiety and age accounted for overall sleep quality.
RESULTS : NFL thickness measured on OCTs varied by location around the optic nerve.
RESULTS : NF-κB-DVH significantly decreased UV-induced expression of TNF-α , IL-1α , MMP-1 and COX-2 while increased production of type I procollagen.
RESULTS : NFκB was most abundant in young erythrocytes but virtually absent in aged erythrocytes.
RESULTS : NH placement totaled @percent@ at 4-year follow-up.
RESULTS : Nicotine and nicotyrine were quantified in all @number@ e-liquids and aerosols.
RESULTS : Nine Chinese patients ( skin types III and IV , mean age @number@ ) were included.
RESULTS : Nine eligible studies were identified , with @number@ participants.
Results : Nine hundred and seventy-six women ( @percent@ ) had ≥1 hospitalization in the @number@ years after the Year @number@ examination.
RESULTS : Nine-hundred ninety-three ( @percent@ ) of the participants were seen by an ear , nose , and throat ( ENT ) specialist.
RESULTS : Nine hundred sixteen patients were treated ( @number@ ( @percent@ ) female , @number@ ( @percent@ ) male ) .
RESULTS : Nine meta-analyses were conducted in this study.
RESULTS : Nine participants with a total of @number@ treatment areas completed three treatments and the 1-month follow-up visit.
RESULTS : Nine population-based studies and seven clinical studies met the inclusion criteria.
RESULTS : Nine RCTs could be included in the study.
RESULTS : Nine studies indicated that comorbidity burden was associated with deterioration in at least one of the three dimensions of LOAD examined.
RESULTS : Nine studies met the inclusion criteria.
RESULTS : Nine studies were eligible for inclusion.
RESULTS : Nine studies were included in this systematic review , with four studies including multiple MRI sequences.
RESULTS : Nineteen interventional studies , including @number@ participants , were identified.
RESULTS : Nineteen out of the @number@ patients scheduled for thyroid surgery ( @percent@ ) at our University Hospital , developed post-operative acute respiratory failure.
RESULTS : Nineteen participants attended @percent@ of scheduled soccer sessions , and none suffered any injuries.
RESULTS : Nineteen patients showed a typical clinical picture with contractures , proximal weakness and slow disease progression while @number@ presented a more severe evolution.
RESULTS : Nineteen reviews were included.
RESULTS : Nineteen studies were identified , @number@ of which found significant differences in Aβ levels between depressed and non-depressed older adults.
RESULTS : Ninety-eight children with @number@ MR studies were identified from the data search.
RESULTS : Ninety-nine out of @number@ ( @percent@ ) patients on anti-TB treatment had AKI.
RESULTS : Ninety-one MRSA BSI episodes were included , of which @number@ ( @percent@ ) were caused by spa types t003 , t032 and t045.
RESULTS : Ninety-one patients completed the study.
RESULTS : Ninety-six ( @percent@ ) were found to have advanced WMLs.
RESULTS : Ninety-three patients were evaluated.
RESULTS : Ninety-two clients completed the validation study.
RESULTS : Ninety-two of @number@ subjects ( mean age , @number@.4±5.5 years ) completed the 12-month follow-up.
RESULTS : Ninety-two participants attended the Forum from Canada , United Kingdom ( UK ) , Ireland and the United States.
RESULTS : Ninety-two ( @percent@ ) patients representative for the entire study population responded.
RESULTS : Ninety-two studies were included.
RESULTS : Ninety-two subjects were included , Cronbach's α of @number@ showed a very good internal consistency of the Arabic AMS questionnaire.
RESULTS : Nitric oxide ( NO ) is the principal factor increasing blood flow into the penis.
RESULTS : No association was found between the total HEI-2005 score and BTMs.
RESULTS : No association was found between VDR polymorphism and CRC specific and all-cause mortality.
RESULTS : No association was noted between entorhinal cortex volume or hippocampal CBV and memory.
RESULTS : No baseline differences were found in GDS across age- and gender-specific tertiles of serum DHEAS.
RESULTS : No baseline differences were observed among groups.
RESULTS : No ceiling or floor effects were identified.
RESULTS : No clear influence of metabolic syndrome on SSe , SZn and SCu concentration and SOD and CAT activity was found.
RESULTS : No clinical feature predicted the probability of having out-of-pocket medical expenditures.
RESULTS : No correlation was found between the Rmax and echogenicity.
RESULTS : No cross-sectional association was found between IL-6 , ACT and CRP with depressive symptoms at baseline.
RESULTS : No departures from linearity were detected.
RESULTS : No difference approached significance between aMCI subjects and HC.
RESULTS : No difference in allelic and genotypic frequencies was found between the two groups ( P > 0.05 ) .
RESULTS : No differences in vaccine responses were found comparing control to MBSR or exercise.
RESULTS : No differences were found between the SMI and LDE groups for study outcomes.
RESULTS : No differences were found for any of the variables between genders.
RESULTS : No differences were observed for any of the blood parameters.
RESULTS : No difference was observed for the assessed parameters between the intervention and the control group at baseline.
RESULTS : No impact of gender and / or age on phonetogram , acoustic voice parameters , and maximum phonation time was detected.
RESULTS : No intraoperative complications , including vascular , neural , urologic , or bowel injuries , were reported.
RESULTS : No major adverse events were recorded.
RESULTS : Nominal associations among common mitochondrial DNA variants and haplogroups were identified but were not statistically significant after adjustment for multiple comparisons.
RESULTS : Non-Hispanic black participants had lower physical capacity than non-Hispanic white participants ( mean @number@ vs @number@ p < @number@ ) .
RESULTS : non-participation in CFAS II was higher than in CFAS I ( @number@ versus @percent@ ) .
RESULTS : Nonresponders at Wave @number@ were more likely to have been frail at Wave @number@
RESULTS : Non-response increased with age , and this increase was more pronounced among women than men.
RESULTS : No older frail treatment participants had an abnormal day @number@ ALT.
RESULTS : No overall significant difference was found in mean P300 ERP between patients and controls in latency or in amplitude.
RESULTS : No patient required supplemental nerve blocks.
RESULTS : No patient was converted to open surgery.
RESULTS : Normalized diameters for the dynamic aortic root varied among the age groups.
RESULTS : Normal ranges for LVSIsys and LVSIdia obtained in this study were slightly higher than previously reported.
RESULTS : No significant adverse side effects were detected or reported.
RESULTS : No significant age- or sex-related differences in the average curvature were detected.
RESULTS : No significant age-related decline in performance appears before age @number@
RESULTS : No significant association was observed for circulating phylloquinone at the genome-wide significance level of @number@ × 10 ( @number@ ) .
RESULTS : No significant differences between groups were observed on widely used clinical measures.
RESULTS : No significant differences in response consistency were attributable to age , gender , education , or immigration background.
RESULTS : No significant differences were found on effect outcomes and adherence between IMP and RCT ( all p≥0.135 ) .
RESULTS : No significant distributions of genotype frequencies were observed between life-satisfied and -unsatisfied groups across those with the three polymorphisms.
RESULTS : No significant effects were found within the ITT analyses.
RESULTS : No significant pre-post difference was found between the traditional or contemporary gallery groups on quantitative measures.
RESULTS : No statistical difference was revealed regarding the contact wear of the restorations ( P = @number@ ANOVA ) .
RESULTS : no statistically significant differences in signs of photodamage following MAL-PDT were observed between blue versus red light treated sides.
Results : No therapy-related TE-SAEs occurred at @number@ month.
RESULTS : No tumor tissue was found in liver and spleen of @number@ groups , and HE staining showed no tumor cells.
RESULTS : Novel alleles were detected at the long extreme of the GTTT-repeat , at 10- and 11-repeats , in the SCZ cases and controls.
RESULTS : NS expression is decreased in AhCPCs relative to FhCPCs , correlating with lowered proliferation potential and shortened telomere length.
RESULTS : NSHAP's protocols yielded U.S. prevalence rates similar to other nationally representative studies of older adults and comparable between waves.
RESULTS : NT-proBNP concentrations showed significant inverse correlations with body mass index ( BMI ) in peri- and postmenopausal women.
RESULTS : @number@ abstracts were retrieved , @number@ full text articles further explored , from which @number@ were excluded.
RESULTS : @number@ adults aged ≥ @number@ within @number@ studies ( @number@ countries and @number@ EU-wide ) were included.
RESULTS : @number@ and @number@ participants in the intervention and control groups completed @number@ months follow-up respectively.
RESULTS : @number@ APOE ε4 carriers and @number@ non-carriers were included.
RESULTS : @number@ articles were found in the literature.
RESULTS : @number@ articles were identified , of which @number@ were included in the review.
RESULTS : @number@ articles were identified of which @number@ with @number@ factors met the inclusion criteria for meta-analysis.
RESULTS : @number@ articles were included in the review ; mean age of the subjects ranged from @number@ to @number@ years old.
RESULTS : @number@ ) As the level of background noise increased , speech perception scores systematically decreased in all the groups.
RESULTS : @number@ athletes in total were screened.
RESULTS : @number@ blood samples were obtained.
RESULTS : @number@ cancer patients , aged 60-95 years , were recruited.
RESULTS : @number@ cases underwent RS ; metastatic pelvic and aortic LNs were documented in @percent@ , and @percent@ of cases , respectively.
RESULTS : @number@ cases were included in this study ( ranged 80-98 , male : female = 9 : 60 ) .
RESULTS : @number@ cases were revised.
RESULTS : @number@ chemical constituents , among which C19-diterpenoid alkaloids and C20-diterpenoid alkaloids are the predominant groups , have been isolated and identified from Fuzi.
RESULTS : @number@ Chinese nonagenarians and centenarians ( @percent@ women , mean age @number@ years ) were included.
RESULTS : @number@ countries were included in the analysis , covering @percent@ of the world's population.
RESULTS : @number@ emergency inpatients with multimorbidity were included.
RESULTS : @number@ indexed articles published between @number@ and @number@ were identified.
RESULTS : @number@ individuals were available for analysis.
RESULTS : @number@ individuals with mean age of @number@ were assessed.
RESULTS : @number@ Italians aged 16 + were included in the study.
RESULTS : @number@ male physicians ≥60 years were analyzed.
RESULTS : @number@ matched pairs were identified based on age , sex , and education.
RESULTS : @number@ men ( @percent@ ) had clinically significant depression and @number@ ( @percent@ ) had subthreshold depression.
RESULTS : @number@ men survived to the age of @number@ years ( @percent@ ) .
RESULTS : @number@ men were eutrophic , @number@ were overweight and @number@ were obese and mostly sedentary , independent of age.
RESULTS : @number@ non-pediatric , non-geriatric females were in the BeCS-14 cohort.
RESULTS : @number@ % of all studies included information on age.
RESULTS : @number@ of @number@ ( @percent@ ) patients were @number@ years or older.
RESULTS : @number@ of @number@ respondents ( @percent@ ) screened positive for possible mild cognitive impairment ( MCI ) or dementia.
RESULTS : @number@ of @number@ subjects completed a course of @number@ treatments and a 1-year follow-up.
RESULTS : @number@ of @number@ total subjects ( @percent@ ) reported RMU.
RESULTS : @number@ of the @number@ evaluated seniors were included in the present analysis.
RESULTS : @number@ opiate dependent SUD and @number@ N-SUD patients were studied.
RESULTS : @number@ out of @number@ websites advertised stem cell clinics.
RESULTS : @number@ papers were identified and analyzed , of which @number@ describe implementations of decision components.
RESULTS : @number@ participants answered all @number@ questions , and @number@ participants ( @number@ % ) presented recurrent falls.
RESULTS : @number@ participants between @number@ and @number@ years of age were tested.
RESULTS : @number@ participants died during mean period of follow-up of @number@ ± @number@ years.
RESULTS : @number@ participants died during the five-year study period.
RESULTS : @number@ participants died , @number@ met the criteria for successful aging.
RESULTS : @number@ participants had incident CHD during a median @number@.3-year follow-up.
RESULTS : @number@ participants ( @number@.52years , @percent@ male ) attended the follow-up ( @percent@ ) .
RESULTS : @number@ participants ( @percent@ ) had CVD ( @percent@ men ) ; @percent@ of participants had a SCREEN II score < @number@
RESULTS : @number@ participants remitted and @number@ did not.
RESULTS : @number@ participants were analyzed post-intervention , @number@ at follow-up.
RESULTS : @number@ participants were diagnosed with incident AD during follow-up ( 1995-2004 ) .
RESULTS : @number@ participants were included in the analysis , mean age @number@ years.
RESULTS : @number@ participants were included with @percent@ female , @percent@ African Americans , and @percent@ who completed at least twelfth grade.
RESULTS : @number@ participants with mean age @number@ ( SD @number@ ) years were recruited.
RESULTS : @number@ participants with @number@ observations and 1-5 visits were included in our analyses for black carbon and PM2.5.
RESULTS : @number@ patients aged > 65 years were enrolled ( @number@ males , @number@ females , mean age @number@ years ) .
RESULTS : @number@ patients between @number@ and @number@ years were under follow-up.
RESULTS : @number@ patients completed the PWS questionnaire.
RESULTS : @number@ patients had usable data.
RESULTS : @number@ patients , mean age @number@ years , were included.
RESULTS : @number@ patients ( @percent@ ) completed the 24-month BP follow-up.
RESULTS : @number@ patients ( @percent@ male , median age @number@ years , IQR 34-66.5 years ) were included.
RESULTS : @number@ patients ( @percent@ male ) with a LOS > 7 days were analyzed.
RESULTS : @number@ patients ( @percent@ ) showed at least one ductular or parenchymal abnormality.
RESULTS : @number@ patients were assessed.
RESULTS : @number@ patients were identified , of whom @number@ were included in the intention-to-treat ( ITT ) cohort.
RESULTS : @number@ patients were included.
RESULTS : @number@ patients were included.
Results : @number@ patients were included in the statistical analyses.
RESULTS : @number@ patients were included in the study of which @number@ ( @percent@ ) were infected with a multidrug resistant pathogen.
RESULTS : @number@ patients were included , @percent@ of all patients and @percent@ of patients ≥70 + suffered functional decline.
RESULTS : @number@ patients were recruited with a mean age of @number@ years ( SD @number@ ) .
RESULTS : @number@ patients were screened.
RESULTS : @number@ patients were treated with memantine and @number@ patients received placebo.
RESULTS : @number@ patients who underwent @number@ treatment courses were included in the study.
RESULTS : @number@ patients with CNV due to AMD , @number@ in @number@ and @number@ in @number@ were included.
RESULTS : @number@ patients with symptomatic hyponatremia ( serum sodium < = 125 mmol / L ) were studied.
RESULTS : @number@ people ( @percent@ women ) became depressed over the @number@ years.
RESULTS : @number@ people were included.
RESULTS : @number@ ( @percent@ ) participants died in a mean follow-up time of @number@ years.
RESULTS : @number@ ( @percent@ ) patients gave a possible cause for their PMR , while @number@ ( @percent@ ) respondents wrote ' no idea'.
RESULTS : @number@ ( @percent@ ) subjects reported SMC.
RESULTS : @number@ ( @percent@ ) subjects were not having CD whereas @number@ ( @percent@ ) patients with CD.
RESULTS : @number@ questionnaires were completed and included in the analysis.
RESULTS : @number@ randomized controlled studies were found to be eligible for inclusion.
RESULTS : @number@ RCT studies met criteria for this review.
RESULTS : @number@ respondents were classified into one of three employment trajectory groups : fully retired , fully employed , or bridge employed.
RESULTS : @number@ studies are included , of which @number@ have data on risk factors associated with psychotropic drugs.
RESULTS : @number@ studies involving @number@ participants were included in the final analysis , including two randomized trials.
RESULTS : @number@ studies that reported on the association between prenatal environmental risk factors and infants born with ARM were included in this review.
RESULTS : @number@ studies were eligible for inclusion , representing @number@ men.
RESULTS : @number@ studies were found , and @number@ remained after screening.
RESULTS : @number@ studies were identified ( @number@ RCTs and @number@ uncontrolled trials ) ; age ranged from @number@ to 80years.
RESULTS : @number@ studies with @number@ cases and @number@ controls were included.
RESULTS : @number@ subjects completed the study.
RESULTS : @number@ subjects completing T2 were largely white ( @percent@ ) , female ( @percent@ ) , well educated and in good health.
RESULTS : @number@ subjects were recruited , @number@ female ( @percent@ ) with a mean age of @number@ years.
RESULTS : ( @number@ ) The GA level of the @number@ subjects was ( @number@ + / - @number@ ) %.
RESULTS : ( @number@ ) The morbidity of HDP was @percent@ in anti-oxidants group vs. @percent@ in control group.
RESULTS : ( @number@ ) There were @number@ acute occupational poisoning accidents for @number@ years with @number@ workers poisoned and @number@ died.
RESULTS : @number@ unspecified polyneuropathy patients were registered.
RESULTS : @number@ Veterans had at least @number@ biomarker measurement available prior to HIV infection and prior to ART initiation.
RESULTS : @number@ women aged 73-94 yr were selected , @number@ of them with mean age @number@.2±6.1 years remained compliant.
RESULTS : @number@ women completed cognitive testing in @number@ @number@ in @number@ and @number@ in @number@
RESULTS : @number@ women described at least one fall.
RESULTS : @number@ women who had baseline and end-of-treatment cognitive function data constituted the analytic sample.
RESULTS : Numerous frameworks have been proposed yet the majority do not address all the barriers.
RESULTS : Nutritional status improved and body weight increased after @number@ months in the intervention group.
RESULTS : Nutritional status in general improved significantly , particularly during the first @number@ months after discharge.
RESULTS : Nuts and seeds intake was positively and linearly associated with telomere length.
RESULTS : Obesity did not show any correlation with the studied peripheral cortisol values.
RESULTS : Obesity increases the risk of CRC by @percent@.
RESULTS : Obesity in early adulthood ( age , mid-20s to mid-40s ) is a significant risk factor for HCC.
RESULTS : Obesity resulted in disturbed mitochondrial biogenesis and function ( respiratory chain complex I ) in the cardiomyocytes of young and old patients.
RESULTS : Objective assessments with super-imposable 3D color images showed statistically significant median volume reduction of @number@ mL after treatments.
RESULTS : Objective memory impairment was evident in @percent@ of elderly adults.
RESULTS : Objective sleep was disrupted in SCD participants , which showed increased nighttime wakefulness and reduced sleep efficiency.
RESULTS : Observation shows that some microrelief features disappear and even merge with wrinkles that become more marked.
Results observed with objective measurements , ie , in vitro assessments and electron microscopy , confirm the firming and restructuring effect clinically observed.
Results obtained with in vitro studies suggest that optimal levels of NO are required for neural tube closure.
Results obtained with other demographic indices are confirmatory.
RESULTS : Octogenarian's motivations for having cardiac surgery include survival , relief of symptoms , convenience and improving quality of life.
RESULTS : Octogenarians showed significantly higher levels of positive emotion than centenarians.
RESULTS : Of all @number@ eligible participants , @number@ ( @percent@ ) adults were diagnosed with ARC.
RESULTS : Of all participants , @number@ and @percent@ had undiagnosed diabetes by FPG≥126 mg / dl and A1c≥6.5% , respectively.
Results of annual health checkups at workplaces revealed a steady increase in the incidence of cardiovascular risk factors such as dyslipidemia and hypertension in Japan.
RESULTS : Of a total of @number@ included patients , @percent@ were females.
Results of biophysical investigations , such as measurement of transepidermal water loss , are discussed regarding their age-dependence.
Results of C9ORF72 screening in @number@ unrelated Iranian ALS patients are reported here.
Results of CDS were dependent on FACIT-F scores in the study group.
Results of combined ultrasound scanning for estimation of acoustic lens density and biometric relations of lens and other eye structures are presented.
Results of error analysis indicated that visual encoding errors were most prevalent.
RESULTS : Offspring groups did not differ on TICS-m scores at baseline.
RESULTS : Offspring provided parents with emotional support and listening more often than other forms of support.
Results of immunofluorescence confocal microscopy for translocation of NF-κB and p-ERK and p-p38 were also checked.
Results of morphometric analysis showed a significant increase in the somatotrope area , and significant decrease in somatotrope volume density and nucleocytoplasmic ratio with age.
RESULTS : Of note , @number@ AMIs ( @percent@ HIV + ) occurred over @number@ years ( median ) .
RESULTS : Of @number@ abstracts reviewed , a total of @number@ studies were included.
RESULTS : Of @number@ admissions , the proportion of potential ADR-related medical admissions was @percent@.
RESULTS : Of @number@ articles , @number@ were conducted in six African countries and included in this review.
RESULTS : Of @number@ articles retrieved , @number@ met our inclusion criteria ; most investigated aerobic exercise alone , and @number@ reported combined exercise training.
RESULTS : Of @number@ charts reviewed , @number@ patients met inclusion criteria.
RESULTS : Of @number@ clinicians in CARRA , @number@ completed surveys ( @percent@ ) , predominantly attending pediatric rheumatologists.
RESULTS : Of @number@ CN participants , @number@ ( @percent@ ) developed MCI.
RESULTS : Of @number@ dyads screened , @number@ ( @percent@ ) were eligible and @number@ ( @percent@ ) randomized.
RESULTS : Of @number@ elderly patients with ART calls , @number@ had repeat ART calls.
RESULTS : Of @number@ eligible parents , @number@ ( @percent@ ) participated.
RESULTS : Of @number@ eligible subjects , @number@ consented to study participation , and @number@ phakic eyes were analyzed.
RESULTS : Of @number@ enrolled patients , @number@ ( @percent@ ) had delirium diagnosed by the psychiatrist reference standard.
RESULTS : Of @number@ enrolled patients with peptic ulcers , @number@ ( @percent@ ) were judged to have IPUs.
RESULTS : Of @number@ family physicians , @percent@ ( n = @number@ ) report providing palliative care.
RESULTS : of @number@ HIV patients ( median age @number@ years ; @percent@ on CART ) , @percent@ had sensory neuropathy ; @percent@ were symptomatic.
RESULTS : Of @number@ included patients , @percent@ were malnourished and @percent@ at risk of malnutrition before HF.
RESULTS : Of @number@ male participants enrolled , a total of @number@ men met our study criteria.
Results Of @number@ NAFLD patients , @number@ patients developed CKD.
RESULTS : of @number@ offspring ( mean age @number@ years , @percent@ women ) , @number@ ( @percent@ ) had ≥1 parent achieve longevity.
RESULTS : Of @number@ older adults , @number@ were having cognitive impairment ( weighted prevalence , @time@ % ) .
RESULTS : Of @number@ older adults surveyed , @percent@ had anxiety disorders and @percent@ reported having any anxiety symptoms.
RESULTS : of @number@ participants , 203 ( @percent@ ) were females.
RESULTS : Of @number@ participants at baseline ( @number@ ) , @number@ ( @percent@ ) reported a history of dementia.
RESULTS : Of @number@ participants , a total of @number@ ( @percent@ ) had a CVD event.
Results : Of @number@ participants ( mean age of @number@ years ) , @number@ were frail.
RESULTS : Of @number@ participants , @number@ continued to receive home care ( @percent@ ) .
RESULTS : Of @number@ participants , @number@ had COPD ( men vs women : @percent@ vs @percent@ ; P < .001 ) .
RESULTS : Of @number@ participants , @number@ ( @percent@ ) attended the 6-month follow-up assessment and completed the questionnaire.
Results : Of @number@ participants , @number@ ( @percent@ ) developed AD dementia and @number@ ( @percent@ ) developed mild cognitive impairment.
RESULTS : Of @number@ participants , @number@ ( @percent@ ) older adults had anemia at baseline [ corrected ] .
RESULTS : Of @number@ participants recruited , data from @number@ patients were complete.
RESULTS : Of @number@ patients admitted to the Geriatric Rehabilitation ward , @number@ were eligible and agreed to participate.
RESULTS : Of @number@ patients enrolled ( mean @number@.7±6.2 years [ range 70-92 years ] ) , @number@ ( @percent@ ) completed the 28-day observation.
RESULTS : Of @number@ patients identified to have AF , @number@ had paroxysmal type , @number@ had persistent type , and @number@ had permanent type.
RESULTS : Of @number@ patients , @number@ had palmar fibromatosis.
RESULTS : Of @number@ patients , @number@ ( median age @number@ years , @percent@ female ) had HTN.
RESULTS : Of @number@ patients , @number@ ( @number@ % ) were taking BZDs at admission and @number@ ( @number@ % ) at discharge.
RESULTS : Of @number@ patients , @number@ ( @percent@ ) had delirium and @number@ ( @percent@ ) had dementia.
RESULTS : Of @number@ patients , @number@ ( @percent@ ) had RLS.
RESULTS : Of @number@ patients , @number@ ( @percent@ ) had urate levels ≥357 µmol / L at screening and required allopurinol up-titration.
RESULTS : Of @number@ patients , @number@ ( @percent@ overall ; @percent@ EVAR and @percent@ OAR ) died ≤30 days of repair.
RESULTS : Of @number@ patients , @number@ ( @percent@ ) were given a diagnosis of GERD based on endoscopy.
RESULTS : Of @number@ patients , @number@ ( @percent@ ) were tested in the morning and @number@ ( @percent@ ) in the afternoon.
RESULTS : Of @number@ patients , @number@ were living in the community and @number@ residing in nursing homes.
RESULTS : Of @number@ patients ( @percent@ ) assessed , @number@ were males , median age @number@ ( 71-81 ) years.
RESULTS : Of @number@ patients presenting with facial fracture , @number@ were older than @number@ years.
RESULTS : Of @number@ patients screened , @number@ patients were FISH-positive and met eligibility criteria for treatment.
RESULTS : Of @number@ patients treated , @number@ had follow-up imaging available with a median follow-up of @number@ months.
RESULTS : Of @number@ patients with AIS who underwent thrombectomy during the study period , @number@ ( @percent@ ) were admitted on a weekend.
RESULTS : Of @number@ patients with c-spine fractures , @number@ ( @percent@ ) were asymptomatic and reported no neck pain on presentation or on examination.
RESULTS : Of @number@ patients with NVUGIB , @number@ % ( @number@ ) were taking at least one antithrombotic agent.
RESULTS : Of @number@ patients with PMBT followed to death in hospice care , @number@ ( @percent@ ) were enrolled within @number@ days of death.
RESULTS : Of @number@ persons who entered ( mean age @number@ + @number@ years , @number@ % female ) , @number@ completed the study.
RESULTS : Of @number@ promoter-associated CpGs analyzed , @number@ showed statistically significant age-dependent methylation gains.
RESULTS : Of @number@ randomized subjects , @number@ completed the trial ( mean age ± SD , @number@.1±6.0y ) .
RESULTS : Of @number@ residents identified by our algorithm , @percent@ were long stay.
RESULTS : Of @number@ residents , @number@ residents completely responded to the questionnaire.
RESULTS : Of @number@ respondents interviewed , @number@ ( @percent@ ) were aged 60-69 years and @number@ ( @percent@ ) were male.
RESULTS : Of @number@ respondents , @percent@ were female and @percent@ were male.
RESULTS : Of @number@ scores , @percent@ of means for parkrunners fell outside overall and age and gender subgroups normative ranges.
RESULTS : Of @number@ selected students , @number@ ( @percent@ ) participated in the study.
RESULTS : Of @number@ students , @number@ ( @percent@ ) completed both an entry and exit questionnaire.
RESULTS : Of @number@ surgeries , @number@ ( @percent@ ) had appropriate preoperative CT scans.
RESULTS : Of @number@ surveys returned ( @percent@ response rate ) , @number@ surveys had complete data for all the variables of interest.
RESULTS : Of @number@ tools identified initially , @number@ were selected.
RESULTS : Of @number@ total studies , @number@ satisfied the inclusion criteria and investigated PI in older adults versus nutritional intake.
RESULTS : Of @number@ women who underwent bilateral oophorectomy before menopause , @number@ developed glaucoma.
Results of our study showed that the age-related atrophy affected all three fibre types.
RESULTS : Of participants , @percent@ reported having at least @number@ CHC , with @percent@ reporting ≥2 CHCs.
RESULTS : Of persons without disabling foot pain at baseline , @percent@ had developed it at @number@ years.
Results of recent studies indicate that nitrite may be effective in the treatment of vascular aging.
Results of recent studies on T-cell ALL and reduced-intensity allografting are reviewed.
RESULTS : Of residents @percent@ were well-nourished and @percent@ malnourished according to the MNA.
RESULTS : Of respondents , @percent@ had at least @number@ BADL limitation ; @percent@ had at least @number@ chronic condition , and @percent@ had MCCs.
Results of SAP and functional tests were significantly positive correlated.
Results of SDMTs with the rearranged and previous regular key were compared.
Results of sensitivity analysis also showed a significant association between higher LDL-C and lower mortality risk.
RESULTS OF SENSITIVITY ANALYSIS : An increased relative risk for functional limitation or mild cognitive impairment of @number@ to @number@ could offset the cardiovascular benefits.
Results of several dietary pattern scores were summarized.
Results of Study @number@ ( N = @number@ ) replicated this result using a lexical-decision task.
Results of Study @number@ provided evidence of substantial measurement and structural invariance of all dimensions across samples.
Results of the assessment of physical activity were verified against the Global Recommendations of Physical Activity for Health.
RESULTS : of the baseline reproductive hormones predicted cognitive decline in men without dementia over @number@ years.
RESULTS : Of the cohort , @percent@ exhibited high-risk CRP levels.
Results of the current study suggested implications for both government and non-governmental organizations to design family-based support for eldercare and improve neighborhood identity for elders.
Results of the elastic net regression showed weak relationships between IL-1Ra and FTC-triphosphate and deoxyadenosine triphosphate exposures , and MIP-1β , age and TFV-diphosphate exposures.
RESULTS : Of the fifty-five included patients , @number@ were frail ( @percent@ ) .
RESULTS : Of the five SNPs evaluated , no SNPs were significantly associated with grade @number@ or higher PIPN.
Results of the individual replication cohorts were combined by meta-analysis.
RESULTS : Of the journals reviewed , fewer than @percent@ of their publications related to palliative care.
Results of the morphometric analysis showed significant increase of the FS cells volume density in cases older than @number@ years.
RESULTS : Of the @number@ ACFs , only inhibition was impaired in aging after controlling for processing speed.
RESULTS : Of the @number@ articles consulted , @number@ met the inclusion criteria.
RESULTS : Of the @number@ CN participants who were amyloid-negative at baseline , @number@ met criteria for incident amyloid PET positivity.
RESULTS : Of the @number@ elderly hospitalized with trauma , @number@ had oral and maxillofacial trauma , with a prevalence of @percent@.
RESULTS : Of the @number@ eligible studies , eight ( n = 661 participants ) met inclusion criteria.
RESULTS : Of the @number@ HIV-infected and @number@ HIV-uninfected participants , @percent@ were women , and @percent@ were current / previous smokers.
RESULTS : Of the @number@ identified articles , @number@ met our eligibility criteria , with a large majority of uncontrolled studies ( @percent@ ) .
Results : Of the @number@ LonGenity participants ( mean age @number@ @percent@ women ) , @number@ were OPEL and @number@ were OPUS.
RESULTS : Of the @number@ male renal-transplant patients , nine were diagnosed with prostate cancer.
RESULTS : Of the @number@ mentors invited , @number@ ( @percent@ ) responded and @number@ ( @percent@ ) provided complete data for the study items.
RESULTS : Of the @number@ MoNNET-HA follow-up participants , @number@ were nonsmokers in @number@
RESULTS : Of the @number@ @number@ asylum seekers , @percent@ were women , @percent@ children aged < 7 years and @percent@ aged > 64 years.
RESULTS : Of the @number@ @number@ @number@ outpatient visits by Medicare beneficiaries , @number@ @number@ @number@ ( @percent@ ) occurred on rainy days.
RESULTS : Of the @number@ @number@ subjects , @number@ @number@ participants were enrolled.
RESULTS : Of the @number@ older persons , apathy was present in @number@ ( @percent@ ) of them.
RESULTS : Of the @number@ online surveys , only @number@ were assumed to have reached the intended recipients ( response rate @number@ % ) .
RESULTS : of the @number@ original articles , @number@ neuropsychological and @number@ brain imaging studies were selected.
RESULTS : Of the @number@ participants analyzed in the study , @percent@ were male and the average age was @number@ years.
RESULTS : Of the @number@ participants included in the analysis , @percent@ were CMV + viremic ; @percent@ CMV + aviremic ; @percent@ CMV-naïve.
RESULTS : Of the @number@ participants interviewed , @percent@ were female and the mean age was @number@ years.
RESULTS : Of the @number@ participants interviewed , @percent@ were female and the mean age was @number@ years.
RESULTS : Of the @number@ participants interviewed , @percent@ were women and the mean age was @number@ years.
RESULTS Of the @number@ participants , @number@ ( @percent@ ) had early AMD and @number@ ( @percent@ ) had late AMD.
RESULTS : Of the @number@ participants , @number@ ( @percent@ ) had functional dependence.
RESULTS : Of the @number@ participants , @number@ ( @percent@ ) had MCI and @number@ ( @percent@ ) had AD.
RESULTS : Of the @number@ participants , @number@ ( @percent@ ) lived alone at baseline.
RESULTS : Of the @number@ participants , @number@ ( @percent@ ) were hypertensive.
RESULTS : Of the @number@ participants , @number@ ( @percent@ ) were identified as frail.
Results : Of the @number@ participants , @number@ ( @percent@ ) were male ; mean ( SD ) age was @number@ ( @number@ ) years.
Results : Of the @number@ participants , @number@ ( @percent@ ) were men ; mean ( SD ) age was @number@ ( @number@ ) years.
RESULTS : Of the @number@ participants , @number@ ( @percent@ ) were weekly and @number@ ( @percent@ ) were daily tea consumers.
RESULTS : Of the @number@ participants , @percent@ were characterized as frail , @percent@ as pre-frail , and @percent@ as non-frail.
RESULTS : Of the @number@ participants , @percent@ were male , @percent@ were married , and @percent@ were retired.
RESULTS : Of the @number@ participants who originally reported exhaustion , @number@ ( @percent@ ) were exhaustion free at least once during follow-up.
Results : Of the @number@ participants who underwent MRI scans , @number@ ( @percent@ ) had CCM.
RESULTS : Of the @number@ participants who were recruited , @number@ were women and @number@ were men.
RESULTS Of the @number@ patients assessed , @number@ were sarcopenic.
RESULTS : Of the @number@ patients included in the study , @percent@ had mild dementia ; @percent@ and @percent@ had moderate and severe dementia.
RESULTS : Of the @number@ patients in our AVM database , @number@ patients were over the age of @number@ at presentation.
RESULTS : Of the @number@ patients , @number@ only received @number@ treatments and was therefore excluded from the statistical analysis.
RESULTS : Of the @number@ patients , @number@ ( @percent@ ) were elderly.
RESULTS : Of the @number@ patients @number@ years of age or older , @number@ underwent OAT for atrial fibrillation ( AF ) .
RESULTS : Of the @number@ patients , @percent@ received non-CYP2D6 BBs , @percent@ , CYP2D6 BBs , and @percent@ , no BBs.
RESULTS : Of the @number@ patients studied , @number@ ( @percent@ ) had a history of criminal behavior that emerged during their illness.
RESULTS : Of the @number@ patients who completed the study , @number@ ( @percent@ ) presented with POCD @number@ week after surgery.
RESULTS : Of the @number@ patients who underwent randomization , @number@ were included in the modified intention-to-treat analysis.
RESULTS : Of the @number@ patients with chronic pain interviewed , @number@ were male , @number@ were younger than age @number@ and @number@ were African-American.
Results : Of the @number@ patients with TNBC , all were women ; the mean ( SD ) age was @number@ ( @number@ ) years.
RESULTS : Of the @number@ proteins previously reported , @number@ AIBL candidates and @number@ non-AIBL candidates were available for testing.
RESULTS : Of the @number@ publications retrieved , @number@ publications ( seven randomized controlled trials , eight observational studies ) were included for review.
RESULTS : Of the @number@ records analyzed , @number@ fulfilled criteria for NGT and had complete biochemical data.
RESULTS : Of the @number@ records identified , @number@ articles met the inclusion criteria.
RESULTS : Of the @number@ references retrieved as a result of our search , six studies met inclusion criteria.
RESULTS : Of the @number@ respondents , @percent@ had an advance directive.
RESULTS : Of the @number@ respondents , @percent@ initially indicated that they intended to work during a flu pandemic.
RESULTS : Of the @number@ respondents , @percent@ was female.
RESULTS : Of the @number@ selected persons , @number@ ( @percent@ ) participated in this study ( age range 55-87 years ) .
RESULTS : Of the @number@ selected studies , @number@ met the selection criteria and were included in the final analysis.
RESULTS : Of the @number@ sources captured , only @number@ concerned technology specifically for older Indigenous adults.
RESULTS : Of the @number@ studied , @percent@ had stage IIIC disease and mean ( SD ) age was @number@ ( @number@ ) years.
RESULTS : Of the @number@ studies included , most assessed health services use ( ie , hospitalizations ) as a secondary outcome.
Results of the @number@ studies provide evidence for an animalistic form of dehumanization of older people by younger ones.
RESULTS : Of the @number@ studies selected for inclusion , @number@ were longitudinal in design.
RESULTS : Of the @number@ subjects , @number@ had lacunar infarctions.
RESULTS : Of the @number@ subjects , @number@ ( @percent@ ) were male and @number@ ( @percent@ ) were female.
RESULTS : Of the @number@ subjects who completed the trial , all recorded improvement in their treated skin ; half reported over @percent@ improvement.
RESULTS : Of the @number@ subjects who underwent ER for gastric neoplasm , @number@ ( @number@ % ) developed pneumonia.
RESULTS : Of the @number@ who met the inclusion criteria , @number@ were elderly who were introduced to full dose chemotherapy.
RESULTS : Of the @number@ women enrolled , @number@ were excluded ( @number@ had baseline UI ; @number@ with missing data ) .
RESULTS : Of the @number@ women who participated , @number@ had undergone forceps delivery , @number@ SVD , and @number@ cesarean delivery only.
RESULTS : Of the originally identified studies , @number@ met our inclusion criteria.
RESULTS : Of the overall sample , @percent@ of the sample ( n = @number@ ) was institutionalized during the study period.
RESULTS : Of the participants , @number@ ( @percent@ ) were classified as having baseline restricted life-space.
RESULTS : Of the participants , @percent@ had high depressive symptom scores ( CES-D ≥ @number@ ) .
RESULTS : Of the participants , @percent@ in the older cohort and @percent@ in the younger cohort had ≥1 limitation.
RESULTS : Of the participants , @percent@ lived alone.
RESULTS : of the participants recalled painful experiences that were not attributable to physical trauma.
RESULTS : of the participants were diabetics , smokers , or met criteria for obesity.
RESULTS : of the permutation-adjusted P values reached statistical significance.
RESULTS : Of the persons with dementia , @percent@ used at least one analgesic drug compared with @percent@ of those without dementia.
RESULTS : of the plasma lipid profile components at the time of enrollment were associated with WMHV.
Results of the present study demonstrated that PKCF could be a promising agent that may find applications in health care , medicine , and cosmetics.
RESULTS : Of the respondents , @number@ subjects ( @percent@ ) were in an OSA high-risk group according to the Berlin questionnaire.
RESULTS : Of the respondents , @percent@ were found to be severely or very severely lonely , while another @percent@ were moderately lonely.
RESULTS : of the restorative systems showed decreased bond strength after storage for one year in artificial saliva.
RESULTS : Of the sample , @percent@ self-reported hearing loss ( @percent@ males ) .
Results of these analyses were used to construct a decision tree-style flow chart for practitioner use.
Results of the second investigation indicated a largely similar performance pattern between healthy older adults and younger adults.
RESULTS : Of the senior author's 25-year database of @number@ patients , @number@ were identified ( @number@ women and seven men ) .
RESULTS : Of the six candidate materials assessed , cigarette paper provided the most practical and reproducible sample acquisition medium.
Results of the study are used to further improve the ambient intelligence technologies and their implementation.
Results of the study demonstrate significant gender differences in aging characteristics.
RESULTS : of the subjects had signs of hypersensitivity and all continued in Phase II.
RESULTS : Of the surveyed population , @percent@ had a hearing loss as measured in the better ear.
RESULTS : Of the total sample , the median and interquartile range value of conditions was @number@ ( 3-5 ) .
RESULTS : Of the tweets , @percent@ occurred before the mammogram compared to @percent@ that occurred afterward ( remainder of tweets indeterminate ) .
Results of the UK Prospective Diabetes Study indicate improvements in cardiovascular outcome and reduced total mortality independent of glycemic control.
Results of the values obtained in A , B , and C positions were compared using a one-way analysis of variance.
RESULTS : Of the whole group of elderly persons , @percent@ had at least one third molar.
Results of this intervention will provide evidence on the effect of a healthful diet on the prevention of age related decline.
Results of this review may suggest that deeper insertion is to be recommended for an older population of cochlear implant recipients.
Results of this review require attention by CPG developers and researchers to develop evidence-based recommendations surrounding spiritual care , EOL , and grief.
Results of this review show empirical evidence to support the efficacy of physical activity for the population with Parkinson's disease.
Results of this study are important for understanding the adult skull and how shape changes may pertain to brain atrophy , aging , and injury.
Results of this study concluded that strength was not significantly affected by aging.
Results of this study contribute to the epidemiologic data on gender differences and age trends in aging male and female femora.
Results of this study indicate a decline in naming performance between oldest and youngest groups.
Results of this study indicated that older adults may prefer certain elements on a trail , namely those elements that afforded their choice of activity.
Results of this study provide further insight into erythrocyte senescence induced by HE.
Results of this systematic review are mixed : CCT was found to increase and decrease both brain structure and function in older adults.
Results of tissue cultures were negative.
Results of tolerance evaluations documented overall treatment mildness for a majority of the study participants.
RESULTS : Of total @number@ subjects , @number@ ( @number@ women ; @number@ men ) were included.
RESULTS : Of women who survived until ≥70 y of age , @number@ women ( @percent@ ) met our criteria for healthy aging.
RESULTS : " Old age symptomatic depression " occurred in @percent@ of the patients in the tested sample.
RESULTS : Older adults demonstrated significantly larger gap detection thresholds than the younger adults.
RESULTS : Older adults expended more listening effort than young adults under both experimental conditions.
RESULTS : Older adults had a larger distance between the hyoid and mandible in both latitude and longitudinal positions compared to the young adults.
RESULTS : Older adults had lower OT , but higher AVP , without the marked gender differences seen in young adults.
RESULTS : Older adults had lower pictogram assessment scores and abstraction and logical abilities when compared with young adults.
RESULTS : Older adults had worse standing balance than younger adults did ( P < @number@ d = @number@ ) .
RESULTS : Older adults ' performance under threat suggested a prevention-focused approach to the task , indexed by increased accuracy and reduced speed.
RESULTS : Older adults performed lower than young adults in the visual and spatial high difficult tasks.
RESULTS : Older adults performed more poorly on precision driving measures and drove more slowly than younger adults at baseline.
RESULTS : Older adults performed the first conflicting response in a series as well as young adults but at a cost to prepotent response performance.
RESULTS : Older adults reported a high rate of approval of PST procedures and acknowledged its positive treatment effect.
RESULTS : Older adults reported less symptomatology than younger patients and younger patients described more personality dysfunction than older patients.
RESULTS : Older adults showed evidence of illusory correlations in source guessing while younger adults did not ; instead they showed evidence of probability matching.
RESULTS : Older adults showed greater prosocial behavior due to the empathy induction than younger adults.
RESULTS : Older adults showed less evidence of processing disruptions at the ambiguous noun phrase ( the food ) than younger adults.
RESULTS : Older adults were found to be weaker , more variable , and less efficient than young participants.
RESULTS : Older adults who did not drive ( former and never drivers ) at baseline had lower average cognitive scores compared with active drivers.
RESULTS : Older adults with depression and healthy comparison participants did not differ in their performance on the Iowa Gambling Task.
RESULTS : Older adults with ongoing exposure reported higher PTSD symptom level relative to those with intense time-limited exposure.
RESULTS : Older adults with OUD were more likely to die from any cause than younger adults with OUD.
RESULTS : Older age was related to lower numeracy and lower need for cognition.
RESULTS : Older cohorts are shown to have equivalent or better SWB than younger cohorts for each well-being measure.
RESULTS : Older HIV-infected patients have lower CD4 ( + ) T cell counts , higher viral load and are more frequently symptomatic at diagnosis.
RESULTS : Older people ( 55 + ) were more likely to live in larger residential homes.
RESULTS : Older people living alone in Mainland China rated social relationships and financial circumstances as sources of low satisfaction within their QoL.
RESULTS : Older people wanted to be included as full citizens in community life with their contributions acknowledged , including as carers.
Results : Older people who engaged in high levels of SOC talk had high well-being despite low physical function.
RESULTS : Older persons are involved in a wide range of care activities with several dependents to care for.
RESULTS : Olfactory disorder assessment is a promising method for improving both the early and differential diagnosis of Alzheimer's disease.
RESULTS : Olfactory functioning was significantly associated with emotional and nonemotional memory.
RESULTS : Olfactory hallucinations were reported in @percent@ of patients with TEA.
RESULTS : OLST , FR , and LR were @number@.5±8.3 s , @number@.8±5.9 cm , and @number@.2±6.4 cm , respectively.
Results on a Rod and Frame test indicated that older women were significantly more visually dependent than the younger women.
RESULTS : On average , both exercise interventions significantly improved physical function.
RESULTS : On average , LGBT older adults first disclosed their identities in their 20s ; many experienced job-related discrimination.
RESULTS : On average , @number@ extrinsic skin ageing symptoms were found among the seafarers without significant differences between ethnic groups.
RESULTS : On average , participants were aged @number@ years and had mild to moderate functional autonomy loss.
RESULTS : On average , people spent @number@ h ( @percent@ of wear time ) as sedentary.
RESULTS : On average , physical impairment increases throughout a resident's stay and is more rapid later in the stay.
RESULTS : On average , regardless of the age group , patients reported @number@ concurrent symptoms.
RESULTS : On average , respondents ' SRTn increased ( i.e. , deteriorated ) significantly over time by @number@ dB signal-to-noise ratio per annum.
RESULTS : On average , tau-positive voxels were closer to the white matter than were Aβ-positive voxels.
RESULTS : On average , the different types of pain shared one-third of the variance in pain catastrophizing.
RESULTS : On average , the platysma extended @number@ cm along the malar mandibular line , superiorly from the inferior border of the mandible.
RESULTS : On average , young-old differ from old-old in indoor physical environmental indicators but not in neighborhood characteristics or social aspects of housing.
RESULTS : One article was selected for review.
RESULTS : One half of the participants were vitamin D deficient ( 25 [ OH ] D < @number@ ng / mL ) at baseline.
RESULTS : One hundred adults with MCI [ @number@ ( @number@ ) years ; @percent@ women ] were enrolled and analyzed.
RESULTS : One hundred and eight patients ( @number@ males and @number@ females ) with a mean age of @number@ years were studied.
RESULTS : One hundred and eleven patients were included.
Results : One hundred and fifty-seven patients were surveyed.
RESULTS : One hundred and nine patients were included ; mean age @number@ ± @number@ years with @number@ patients in the ancillary study.
RESULTS : One hundred and nine subjects ( @percent@ ) carried Apo E ε4 and @number@ ( @percent@ ) carried Apo E ε2.
RESULTS : One-hundred and ninety CT scans and @number@ follow-up datasets from @number@ patients were available for analysis.
RESULTS : One hundred and ninety-five patients were randomized.
RESULTS : One hundred and ninety-one patients were included.
RESULTS : One hundred and sixty-five DPTs were obtained from children with Mongoloid skeletal pattern.
RESULTS : one hundred and thirty-three individuals with a mean age of @number@ years ( range 72-97 ) completed the study.
RESULTS : One hundred and twenty-one patients underwent LDS between @date@ and @date@ .
RESULTS : One hundred and two patients ( @number@ % ) among @number@ showed abnormal EEG findings before revascularization surgery.
RESULTS : One-hundred community dwelling older persons ( aged over @number@ years ) were recruited.
RESULTS : One hundred consecutive CT imaging studies were selected for review ( @number@ men , @number@ women ) .
RESULTS : One hundred fifty incident AD cases ( @percent@ ) died during the course of @number@ ( SD , @number@ ) years of follow-up.
RESULTS : One hundred fifty-seven patients with glaucoma and @number@ patients with pseudophakic eye were subjected to the analysis.
RESULTS : One hundred forty-four photos and reflections were submitted , representing students ' appreciation of diverse facilitators and challenges to rural nursing practice.
RESULTS : One hundred forty-seven men died during a median follow-up of @number@ years.
RESULTS : One hundred forty subjects ( @number@ men ) with mean age ( SD ) of @number@ ( @number@ ) years completed @number@ ISWTs.
RESULTS : One hundred seventy-seven men participated ( mean age = @number@ years , range = 23-83 ) .
RESULTS : One hundred sixty-nine participants ( @percent@ ) had an incident fall over a mean follow-up of @number@.1±12.2months.
RESULTS : One hundred sixty-three patients were reviewed , with a 1 : 1.03 ratio of male to female patients.
RESULTS : One hundred ten SRs with @number@ primary studies satisfied the inclusion criteria.
RESULTS : One hundred ten women were enrolled and collectively received @number@ treatment cycles with botulinum toxin.
RESULTS : One hundred thirty-five grants were identified.
RESULTS : One hundred thirty-four carriers were identified.
RESULTS : One-hundred twelve compounds of Eucommia ulmoides , including the main active constituents , lignans and iridoids , have been isolated and identified.
RESULTS One hundred twenty-five patients undergoing lumbar decompression and fusion were enrolled in this pilot program.
RESULTS : One hundred women had UI and information about absorbent products use.
RESULTS : One month after treatment significantly more than @percent@ of patients were rated as responders.
RESULTS : One pharmacokinetic study , @number@ clinical trials , and @number@ guidelines were identified as relevant to digoxin use specifically in the elderly.
RESULTS : one school only taught pre-clinical medicine and declined to participate.
RESULTS : One spouse's health shock affects the health of the other partner.
RESULTS : One-third of disabled elderly people receive no care.
RESULTS : One thousand and eighty five residents finally took part in this study , and the inclusion ratio was @percent@.
RESULTS : One thousand ninety-two patients were included : nT was observed in @number@ patients ( @percent@ ) .
RESULTS : One thousand six hundred fifty one men without MetS at baseline were identified.
RESULTS : One volunteer route , comprising six congregations that delivered meals to sixteen homebound older adults , was created.
RESULTS : Only in the CBT group did salivary cortisol levels significantly decrease after intervention , with a large effect size and high achieved power.
RESULTS : Only @number@ participants discussed medication cost during their glaucoma office visit.
RESULTS : Only @number@ + SED and @number@ + PF displayed significantly lower overall and type IIa fibre sizes vs. YA.
RESULTS : Only one non-randomized study was included.
RESULTS : Only one significant difference was found between the control and experimental group.
RESULTS : Only @percent@ of AD and @percent@ of MCI responded correctly about the recent news while @percent@ of NC responded correctly.
RESULTS : Only @percent@ of older adults with diabetes receiving metformin were tested for vitamin B12 status after long-term metformin prescription.
RESULTS : Only @percent@ of the Jewish sector and @percent@ of the Arab sector are sufficiently active.
RESULTS : Only @percent@ to @percent@ of the population reported trust in others and shared values.
RESULTS : Only seven studies fulfilled the inclusion criteria.
RESULTS : Only the physical function of SF-36 was slightly positively affected by the intervention ( p = 0.04 ) .
RESULTS : Only the spatial training improved performance in the maze task.
RESULTS : Only three out of @number@ comparisons ( two eyes × four Df parameters × three cognitive measures ) were found to be significant.
Results on the association of MetS with dementia and cognitive decline have been inconsistent.
RESULTS : On the whole , analyses revealed no significant association between subjective sleep parameters and CIND.
RESULTS : On T₁-weighted @number@.0T MRI , layers could be visualized at @number@ weeks GA and appeared clearer after @number@ weeks GA.
RESULTS : Organizational practices of employing PSWs in full-time or guaranteed hours are not associated with their life and work stress.
RESULTS : OSAS was more frequent in the postmenopausal groups , with @percent@ of women affected by severe OSAS belonging to the late postmenopause group.
RESULTS : Our analysis confirms the significance of many factors affecting life satisfaction among the oldest-old in China.
RESULTS : Our analysis focused on @number@ patients followed up during @number@ months and evaluated at each visit.
RESULTS : Our best-fitting model has @number@ latent classes.
RESULTS : Our candidate study found a significant association between SNP rs2066853 in exon @number@ of the aryl hydrocarbon receptor gene AHR and crow's feet.
RESULTS : Our data showed that UMSCs and PMSCs fitted well with the minimum standard of MSCs as well as BMSCs and AMSCs.
RESULTS : Our data show that TARC-PE38 efficiently killed HTLV-1-infected cell lines.
RESULTS : Our data suggest no generalized alteration in MI of walking with different task requirements among older adults.
RESULTS : Our findings from fully-adjusted models on Swedish data support claims of excess mortality risks in specific categories of foreign-born.
RESULTS : Our findings highlight the importance of relative poverty for mortality.
RESULTS : Our findings indicate that the age-related decrease in negative affect is mediated by mindfulness.
RESULTS : Our findings reveal that risk-taking tendencies in the financial domain reduce steeply in older age ( at least for men ) .
RESULTS : Our findings suggested that older adults who received relaxation interventions experienced greater reductions in depression and anxiety than controls in most studies.
RESULTS : Our findings suggest that OCD with and without OCPD are similar in terms of gender distribution and age at onset of OC symptoms.
RESULTS : Our findings were that older haenyeos still retain local cold tolerance on the extremities despite their aging.
RESULTS : Our immunohistochemical stainings revealed the presence of N- and C-terminus-containing Reelin fragments in corpora amylacea ( CAm ) , aging-associated spherical deposits.
RESULTS : Our initial protein sequence analysis showed that contactin-2 harbors a strong putative BACE1 cleavage site close to its GPI membrane linker domain.
RESULTS : Our method successfully detected and classified cells in @number@ human brain images.
RESULTS : Our model with the six variables consistently selected in every cross-validation loop had a mean squared prediction error of @number@
RESULTS : Our multivariate analysis suggested that performance in each domain of cognitive function was inversely associated with age and positively related to education.
RESULTS : Our results indicate that motor learning is significantly reduced in former concussed athletes relative to controls.
RESULTS : Our results showed that children and adolescents with concussion exhibit gender differences with respect to risk factors , recovery , and symptomatology.
RESULTS : Our results showed that older participants felt postprandially less hungry and more full.
RESULTS : Our results showed that uncrowded and crowded visual acuities do not change significantly as a function of age.
RESULTS : Our results suggest similarities and differences in factors influencing health ratings across evaluators but a high level of interevaluator disagreement in ratings.
RESULTS : Our results supported both the psychometric stability of our self-report measures , and the preliminary validity of our index of allostasis.
RESULTS : Our search provided @number@ publications.
RESULTS : Our search returned @number@ studies.
RESULTS : Our search returned @number@ studies , @number@ of which satisfied the inclusion criteria.
Results : Our studies demonstrate that Prom1 is primarily a cytosolic protein in the RPE.
RESULTS : Our study demonstrates an increase of AGEs together with a decrease of RAGEs in IPF lungs , compared with control samples.
RESULTS : Our study gives information about the reference values in children between birth to @number@ years of age.
RESULTS : Our study included @number@ older adults.
RESULTS : Our study population had a mean age ( standard deviation ) of @number@ ( @number@ ) years , and @percent@ had MetS.
RESULTS : Our study reveals that colorectal adenocarcinoma genomes , on average , contains up to @number@.2-fold more somatic NUMTs than matched normal genomes.
RESULTS : Our study showed that the HPV prevalence in Fujian province was @percent@.
RESULTS : Outcome measures showed a statistically significant reduction of CG , depressive and traumatic symptoms compared to the controls.
Results : Outcomes based on the accumulation and incidence of age-related chronic diseases are attractive for clinical trials targeting aging.
RESULTS : Out of a total of @number@ decision aid development projects , @number@ ( @percent@ ) specifically involved members of vulnerable populations.
RESULTS : out of a total of @number@ @number@ residents were recruited.
RESULTS : Out of @number@ caregivers interviewed , @percent@ reported helping to keep track of care recipients ' medications and @percent@ assisting with injecting medications.
RESULTS : Out of @number@ enrolled patients , most patients ( @percent@ ) with solid tumor were categorized as TNM stage IV.
RESULTS : Out of @number@ patients , @number@ ( @percent@ ) had concomitant hyperthyroidism and AF at diagnosis.
RESULTS : Out of @number@ patients , @number@ received at least one RBC unit.
RESULTS : Out of @number@ persons aged ≥60 years , @number@ ( @number@ % ) were enrolled.
RESULTS : Out of @number@ questionnaires sent , @number@ responded ( @percent@ ) .
RESULTS : Out of @number@ studies selected , @number@ met inclusion criteria for the review.
RESULTS : Out of @number@ subjects , @number@ ( @percent@ ) subjects had normal glucose tolerance.
RESULTS : Out of @number@ TNBC patients @percent@ were < 65 years and @percent@ were ≥65 years.
RESULTS : Out of the @number@ patients enrolled in the study , @number@ ( @percent@ ) were excluded due to loss of follow-up.
RESULTS : Out of the @number@ patients who were interviewed , @number@ ( @percent@ ) described AWP.
RESULTS : Over a follow-up of @number@.7years , the incidence of all-cause mortality was @percent@ ( N = 867 ) .
RESULTS : Over a lifetime , the gastric mucosa became abnormal in @percent@ of subjects.
RESULTS : Overall 5-year survival was @percent@ , and overall hospital mortality was @percent@ , with @percent@ in elective cases and @percent@ after urgent surgery.
RESULTS : Overall and across municipalities , loneliness estimates did not significantly differ between @number@ and @number@
RESULTS : Overall and in small-scale societies , later age at menarche is associated with shorter adult stature.
RESULTS : Overall , attitudes to aging were positive in this sample.
RESULTS : Overall , bilingual patients developed dementia @number@ years later than the monolingual ones.
RESULTS : Overall , bowel continence was associated with the greatest bother and constipation the least.
RESULTS : Overall , caregivers believed the intervention was beneficial , and most participants with dementia wore the amplification device daily.
RESULTS : Overall compliance rates were @percent@ for event-contingent and @percent@ for signal-contingent compliance.
RESULTS : Overall compliance was @percent@ with pedometer use and @percent@ with the mobile phone physical activity diary.
RESULTS : Overall , data of @number@ participants ( mean age @number@ ± @number@ years , male @percent@ ) were retrieved for analysis.
RESULTS : Overall , data of @number@ patients were used for analysis.
RESULTS : Overall , diabetes increased the HR of first-ever ischemic stroke by about @percent@ in both genders.
RESULTS : Overall , few differences between countries were founded.
RESULTS : Overall levels of neuropsychiatric symptoms increased over the @number@ years.
RESULTS : Overall , mean PHQ score was significantly higher among women compared with men.
RESULTS : Overall , memory worsened from age @number@ years through the 90s.
RESULTS : Overall , no association was observed between ET and the MAPT H1 haplotype.
RESULTS : Overall , nondrinkers did not differ from light drinkers in dementia risk.
RESULTS : Overall , @number@ articles were identified , with three studies eligible for inclusion ( n = @number@ participants ) .
RESULTS : Overall , @number@ Caucasian participants ( @percent@ women ) , mean age of @number@.7±9.3 years were included.
RESULTS : Overall , @number@ consecutive stroke patients ( mean age , @number@ years ; @number@ % males ) were included.
RESULTS : Overall , @number@ deaths occurred during @number@ years of follow-up.
RESULTS : Overall , @number@ hip fracture patients ( mean age @number@ ± @number@ years , @percent@ men ) were recruited for the present study.
RESULTS : Overall , @number@ individuals participated in this study.
RESULTS : Overall , @number@ Medicare patients had @number@ fractures and @percent@ of fractures were nonunion.
RESULTS : Overall , @number@ men ( mean age : @number@.5±4.7 years ) were enrolled for study and the prevalence of MetS was @percent@.
RESULTS : Overall , @number@ of the @number@ centers ( @percent@ ) completed the questionnaire.
RESULTS : Overall , @number@ participants aged @number@ and older were included in this study , of whom @number@ died from cardiovascular disease.
RESULTS : Overall , @number@ participants contributed data to the ROCF analyses and @number@ subjects contributed to the CTRM and DSST analyses.
RESULTS : Overall , @number@ participants ( @percent@ ) met the criteria for pathological diagnosis of AD.
RESULTS : Overall , @number@ patients ( @percent@ ) experienced at least @number@ in-hospital complication or death.
RESULTS : Overall , @number@ patients were categorized as elderly.
RESULTS : Overall @number@ patients were randomized to imiquimod @percent@ , @percent@ , or vehicle.
RESULTS : Overall , @number@ patients with dementia ( mean age @number@ ± @number@ years , @percent@ male ) participated.
RESULTS : Overall , @number@ ( @percent@ ) of the patients analyzed had poor outcomes.
RESULTS : Overall , @number@ RCTs ( n = @number@ ) and @number@ CTs ( n = @number@ ) were included.
RESULTS : Overall , @number@ residents were enrolled and @number@ of them completed the study.
RESULTS : Overall , @number@ studies could be included and meta-analyses could be performed for body weight and fat weight.
RESULTS : Overall , @number@ studies were identified including @number@ participants ( @percent@ men ) with age ranges from @number@ to @number@ years old.
RESULTS : Overall , @number@ study participants had a nonfatal and @number@ a fatal CVD event during @number@ years of follow-up.
RESULTS : Overall , @number@ subjects enrolled.
RESULTS : Overall , @number@ surveys were completed by SAH program participants and @number@ were completed by control group participants.
RESULTS : Overall obesity existed in @percent@ of men and @percent@ of women.
RESULTS : Overall , participants ' mean age was @number@ years and @percent@ ( n = @number@ ) had high risk APOL1 status.
RESULTS : Overall , @percent@ ( 85 / 1014 ) of the examined patients showed positive antibodies against T. gondii.
RESULTS : Overall , @percent@ had received the influenza vaccine in @number@
RESULTS : Overall , @percent@ ( n = @number@ ) of participants had VitD insufficiency defined as 25OHD < 30 ng / ml.
RESULTS : Overall , @percent@ ( n = @number@ ) of the participants were able to manage their medication by themselves at home.
RESULTS : Overall , @percent@ ( @number@ , 032 / 5 , 256 ) of participants declined in health literacy score over the follow-up.
RESULTS : Overall , @percent@ of all deaths were from a dementia-related disease , ranging from @percent@ in Mexico to @percent@ in Canada.
RESULTS : Overall @percent@ of male respondents reported military exposure.
RESULTS : Overall , @percent@ of men and @percent@ of women ate with others three times a day.
RESULTS : Overall , @percent@ of men had ABI < 0.9.
RESULTS : Overall , @percent@ of subjects had a high anticholinergic burden and @percent@ had a low burden.
RESULTS : Overall , @percent@ of the participants took sedative drugs , most frequently hypnotics and antidepressants.
RESULTS : Overall , @percent@ of the sample that had valid MRI ( n = 676 ) had brain IDs.
RESULTS : Overall , @percent@ of the serum samples tested were positive for IgM and IgG antibodies against B. microti , suggesting exposure to TBD.
RESULTS : Overall , @percent@ of the studied population presented a high risk of malnutrition.
RESULTS : Overall , @percent@ of tumors were B-K fusion positive.
RESULTS : Overall , @percent@ ( @percent@ confidence interval ( CI ) = @number@.9-5.5% ) of the cohort took a bladder antimuscarinic.
RESULTS : Overall , @percent@ reported depressive symptoms ( ≥5 ) ; @percent@ correctly identified the person in the vignette as depressed.
RESULTS : Overall , @percent@ reported no regular physical activity.
RESULTS : Overall , @percent@ were classified as frail , @percent@ prefrail and @percent@ non-frail.
RESULTS : Overall , @percent@ women reported regular attendance in organized religious practice , and @percent@ reported engaging in private spiritual practices.
RESULTS : Overall , positive attitudes towards older people were found and there was a relationship between greater knowledge about ageing and more positive attitudes.
RESULTS : Overall prevalence of ADL limitations was @percent@.
RESULTS : Overall prevalence of falling and multi-morbidity were @percent@ and @percent@ respectively.
RESULTS : Overall prevalence of food insecurity was @percent@.
RESULTS : Overall prevalence of microbleeds increased from @percent@ at baseline to @percent@ at follow-up.
Results : Overall prevalence of OD was @percent@ ( CI : @number@ @number@ ) .
RESULTS : Overall , ten individual-level studies were included that reported on the association between circulating vitamin D levels and OC incidence.
RESULTS : Overall , the 10th survival percentile was @number@ years , that is , @percent@ of the cohort lived longer than @number@ years.
RESULTS : Overall , the fit of the super-items to the Rasch model was good , with little evidence of misfit.
RESULTS : Overall , the mean PSA and PSAV were @number@ ng / mL and @number@ ng / mL / y , respectively.
RESULTS : Overall , the prevalence of sarcopenia was @percent@ by using RASM.
RESULTS : Overall , there were reliable individual differences with regard to both subjective organization and verbal learning.
RESULTS : Overall , these components explain @percent@ to @percent@ of the education gradient in prevention , with income being the most important.
RESULTS : Overall , these studies involved @number@ patients undergoing palliative surgery for MBO caused by PC.
RESULTS : Overall , the two dichotomies ( scales # 1 & # 2 ) showed the weakest construct validity with the health outcome variables.
RESULTS : Over a mean follow-up of @number@ ± @number@ months , @number@ falls occurred.
RESULTS : Over a mean follow-up of @number@ ± @number@ months , @number@ participants fell.
RESULTS : Over a mean follow-up of @number@ years , @number@ participants ( @percent@ ) fell.
RESULTS : Over a mean follow-up time of @number@ years , @number@ individuals died , and @number@ deaths ( @percent@ ) were by cardiovascular disease.
RESULTS : Over a mean of @number@ y , @number@ deaths occurred.
RESULTS : Over a median follow-up of @number@ years , a total of @number@ ( @percent@ ) participants developed AF.
RESULTS : Over a median follow-up time of @number@ years , @number@ of the @number@ participants met MCR criteria.
RESULTS : Over an average follow-up of @number@ years ( median follow-up , @number@ years ) , there were @number@ deaths.
RESULTS : Overexpressing both wild-type and R268Q PMCA4 significantly reduced maximum calcium surge after KCl-induced depolarization as compared with vector control cells.
RESULTS : Over five months , @number@ older people with dementia were recruited ( @percent@ of sampling frame ) .
RESULTS : Over follow-up , @number@ ( @percent@ ) participants developed dementia.
RESULTS : Over half of canceled trips were attributed to client reasons ( e.g. , no show , refusal ) .
RESULTS : Over half the study members reported a change in alcohol consumption over the past decade ( @percent@ decreased , @percent@ increased ) .
RESULTS : Over median follow-up of @number@ years ( interquartile range @date@ @number@ ) , @number@ participants ( @percent@ ) developed AF.
RESULTS : Over @number@ Chinese patients were evaluated in our outreach clinic.
RESULTS : Over @number@ months , home-based providers made @number@ telephone calls and sent @number@ faxes to other personnel , on average per participant.
RESULTS : Over @number@ months , @number@ falls were video-captured.
RESULTS : Over @number@ years ( median ) , @number@ incident AMIs occurred.
RESULTS : Over @number@ years , @number@ incident strokes occurred.
RESULTS : Over @number@ years , @number@ one-year transitions were observed.
RESULTS : Over @number@ years , @number@ ( @percent@ ) participants developed HF.
RESULTS : Over one-third of participants had at least one type of interaction.
RESULTS : Over one third of the individuals ( @percent@ ) had @number@ or more concurrent symptoms.
RESULTS : Over @percent@ ( n = @number@ ) reported internal funds covered services not reimbursed by insurers ; @percent@ used funds in last year.
RESULTS : Over @percent@ of children and @percent@ of parents reported parents acting in ways attributed to stubbornness at least sometimes.
RESULTS : Over @percent@ of older adults failed to consume @number@ cups of combined fruits and vegetables.
RESULTS : Over @percent@ of our cohort was older than @number@ years.
RESULTS : Over the follow-up periods , @percent@ of older adults developed functional limitations.
RESULTS : Over the @number@ years , there was a progressive decrease of body weight and waist circumference.
RESULTS : Over the past two decades , @number@ different bioactive polyphenols / phlorotannins have been isolated and studied from @number@ different brown algae.
RESULTS : Over the study period , @number@ cases of newly diagnosed COPD occurred in women and @number@ in men.
RESULTS : Over the study period , @number@ participants developed dementia ( @number@ with Alzheimer's disease ( AD ) ) .
RESULTS : Over up to @number@ years of follow-up ( mean @number@ years ) , @number@ of @number@ ( @percent@ ) participants died.
RESULTS : Oxygen therapy increased from @percent@ in @number@ to @percent@ in @number@ ( p-value of trend < 0.001 ) .
RESULTS : Pain assessment knowledge improved postvideo and at the four-week follow-up.
RESULTS : Pain intensity difference ( PID ) was found in @percent@ of patients.
RESULTS : Pain prevalence was dependent on type of resident and ranged between @number@ and @number@ %.
RESULTS : Pain scores at each time period were predictive of increased agitation and depression and decreased pleasant event frequency @number@ months later.
RESULTS : Pairs of sensitivity recovery functions were generated from the stimuli.
RESULTS : Parafoveal contrast thresholds showed a steeper decline and higher correlation with age at the parafovea than the fovea.
RESULTS : Parametric linkage and haplotype analysis mapped both families to FCD2 with significant two-point LOD scores.
RESULTS : Parathyroidectomy alone was performed in @percent@ of patients.
RESULTS : Part D narrowed racial / ethnic disparities in hospital utilization.
RESULTS : Participants ' breadth of ICT activities showed a significant trend across @number@ months.
RESULTS : Participants described and resolved many challenges including adjustment to new situations and cultures , work-related challenges , and readjustment to home.
RESULTS : Participants ' descriptions of their TKA experiences were primarily concerned with support , or the provision of aid and assistance.
RESULTS : Participants exhibited worse performance on sentences with non-canonical word order than canonical word order.
RESULTS : Participants from Canadian cities have less adverse childhood conditions and better childhood self-reported health.
RESULTS : Participants had a mean age of @number@ ( SD = @number@ ) years , @percent@ were African American , and @percent@ women.
RESULTS : Participants had a mean of @number@ ± @number@ geriatric conditions.
RESULTS : Participants had a mean ± SD age of @number@ ± @number@ years and @percent@ were male.
RESULTS : Participants had a median age of @number@ years [ IQR 54-61 ] , @percent@ were men , and @percent@ were African American.
RESULTS : Participants included @number@ patients aged between 60-99 years and their partners or relatives where applicable.
RESULTS : Participants ' living alone ' were @number@ ( @percent@ ) .
RESULTS : Participants ' mean age was @number@.4±4.2 years and @percent@ were female.
RESULTS : Participants ' mean age was @number@ years , @percent@ were female , and @percent@ were non-Hispanic white.
RESULTS : Participants ' ( N = @number@ ) average age was @number@ for those randomized to intervention and @number@ for those randomized to control.
RESULTS : Participants ( n = @number@ ) included nurses , physicians , food service workers , dietitians , and hospital management , among others.
RESULTS : Participants of this study were followed from @number@ to @number@ leading to @number@ person-years of observation.
RESULTS : Participants presented severe LBP ( @number@.18 / 10 , SD : @number@ ) .
RESULTS : Participants provided retrospective information on complementary therapy use and information on the use of therapies for specific symptoms experienced across @number@ person days.
RESULTS : Participants reported high life satisfaction ( median @number@ out of @number@ points ) despite having representative levels of disease and disability.
RESULTS : Participants reported significant improvements in knee joint pain and function and demonstrated significant increases in thigh muscle strength about the degenerative knee.
RESULTS : participants were eligible for @number@ QIs.
RESULTS : Participants were followed until long-term nursing home residence , disenrollment from Medicare plan , death , or @date@ .
RESULTS : Participants were highly adherent to their medications.
RESULTS : Participants were predominantly female ( @percent@ ) and Hispanic ( @percent@ ) .
RESULTS : Participants were primarily male , white , highly educated , and in good health.
RESULTS : Participants were randomized after baseline assessment-190 each to the intervention and control groups.
RESULTS : Participants whose mothers had few problems generally reported low levels of depressive symptoms.
RESULTS : Participants with better cardiorespiratory fitness had higher cognitive test scores at midlife.
RESULTS : Participants with chronic pain performed worse on tests of working memory and verbal episodic memory.
RESULTS : Participants with CP reported more pain as well as more reduced touch sensitivity and quality of life than healthy controls.
RESULTS : Participants with faster baseline gait had lower rates of incident disability.
RESULTS : Participants with longer diabetes duration had significantly lower gray matter volumes , primarily in certain regions in the frontal and temporal lobes.
RESULTS : Participants with poor maximal reach attempted shorter reaches than those who had good reaching ability.
RESULTS : Participants with SO showed lower physical fitness levels compared with normal subjects.
RESULTS : Participation in voluntary organizations was associated with higher positive affect , higher life satisfaction , and fewer depressive symptoms in younger adults.
RESULTS : Participation was @percent@ ( 559 / 909 ) .
RESULTS : Path analysis showed that the effect of generative action on ill-being was mediated by perceived rejection and respect from younger generations.
RESULTS : patients aged @number@ and over were less likely to have stage I disease and to undergo optimal surgery.
RESULTS : Patient satisfaction was extremely high following both techniques.
RESULTS : patients averaged @number@ ± @number@ years old with @percent@ having evidence of cognitive impairment.
RESULTS : Patient scores showed rhytid improvement only with HF treatments.
RESULTS : Patients diagnosed with ACA were on average @number@ years older than patients with EM ( p < 0.001 ) .
RESULTS : Patients experienced improved results , with a smoother appearance to the brow.
RESULTS : Patients given unilateral , bifrontal , and bitemporal treatments were similar with respect to personal , clinical , and treatment characteristics.
RESULTS : Patients in group A showed substantially more comorbidities as reflected in significantly higher MCS and ASA scores ( P < @number@ ) .
RESULTS : Patients in the DHEA group had a significantly higher live birth rate compared with controls ( P < 0.05 ) .
RESULTS : Patients ' mean age was @number@ ± @number@ years.
RESULTS : Patients ( n = @number@ ) were older ( @number@ ± @number@ years ) and male ( @percent@ ) .
RESULTS : Patients performed significantly worse than the comparison group on all neuropsychological measures.
RESULTS : Patients possessed antiretroviral drugs in @percent@ of the person-months.
RESULTS : Patients ranged in age from @number@ to @number@ years ( mean±SD , @number@.3±12.8 ) .
RESULTS : Patients receiving combination therapies for BPH are likely to be older and are more likely to be retired than those on monotherapy.
RESULTS : Patients were 52±13 years old , @percent@ were males and @percent@ were diabetics.
RESULTS : Patients were 65-91 years old.
RESULTS : Patients were hospitalized for mean of @number@.8±31.4 days ( 1-310 days , median @number@ days ) .
RESULTS : Patients were matched for age , gender , and disease severity.
RESULTS : Patients were @number@ ± @number@ years and had a mean disease duration of @number@ ± @number@ years.
RESULTS : Patients were @number@ ± @number@ years old ; @number@ ( @percent@ ) were women.
RESULTS : Patients with breast cancer undergoing radiotherapy rated their quality of life with an average of @number@ points.
RESULTS : Patients with bvFTD and SD spent more time in bed at night compared to their caregivers.
RESULTS : Patients with cirrhosis had biventricular dilatation , increased LV mass , impaired LV diastolic function , and biventricular systolic strain compared with controls.
RESULTS : Patients with delusions had lower Dementia Rating Scale memory subscale scores.
RESULTS : Patients with epinephrine-producing tumors were diagnosed @number@ yr later ( P < @number@ ) than those with tumors lacking appreciable epinephrine production.
RESULTS : Patients with late-life SSD exhibited a lower Mini-Mental State Examination total score and attention decline.
RESULTS : Patients with MCI generally reported SCD more often than healthy older adults.
RESULTS : Patients with Medicaid or no insurance presented at later stages and were less likely to receive definitive surgery.
RESULTS : Patients with osteopenia or osteoporosis had lower mtDNA copy numbers than normal subjects ( p < @number@ ) .
RESULTS : Patients with PCa showed higher TG / HDL-chol and diminished HDL-chol than Controls and BPH.
RESULTS : Patients with PD-MCI has significantly poorer sleep efficiency compared to those without PD-MCI.
RESULTS : Patients with VO more often had pulse wave velocity ( PWV ) in the aorta which corresponded to criteria of early vascular aging.
RESULTS : Pax7 + SC were significantly increased in young men @number@ h following RE.
RESULTS : PCA was applied to a set of training spectra of human meibum to predict the age of meibum donors.
RESULTS : pCBF ( ASL ) correlated to pCBF ( PCMRI ) ( r = @number@ P < @number@ ) .
RESULTS : PCV7 was phased out by @date@ .
RESULTS : PD admissions had @percent@ increased adjusted prevalence of bone fracture.
RESULTS : Peak BOLD microvascular responses were reduced for OA compared with YA.
RESULTS : Peak oxygen uptake was strongly correlated with MitoVd in @number@ 60- to 80-year-old adults.
RESULTS : Pegvisomant decreased serum IGF-I by @percent@ ( p < 0.01 ) and serum IGFBP-3 by @percent@ ( p < 0.05 ) .
RESULTS : Pensions provide the main source of income for urban elderly , while the principal income source for rural elderly is their family.
Results : : people-centered care starts when community members and healthcare providers foreground health and social issues among community members and families.
RESULTS : people who left school at an older age had a delayed onset of terminal decline.
RESULTS : People who used failure words more frequently exhibited shorter subsequent life spans , and this relationship remained significant when controlling for birth year.
RESULTS : People with diabetes had lower mean cognitive ability scores at ages @number@ and @number@ when compared with those without diabetes.
RESULTS : People with difficulty in carrying out activities of daily living are much older , frequently women and with low education and income levels.
RESULTS : People with low mood at baseline had a @number@.7-fold ( @percent@ CI @number@ to @number@ ) increased risk of developing MCI at follow-up.
RESULTS : Perceived burdensomeness mediated the relation between depression and suicide ideation , accounting for @percent@ of the variance in suicide ideation.
RESULTS : Perceived-health stress had stronger impacts on depressive symptoms than most other stress situations.
RESULTS : Perceived life constraints and physical problems significantly affected the acquisition of positive affect among the elderly.
RESULTS : Perceived need , medication effectiveness and medication safety were identified as critical influences on women's views about prescription osteoporosis medication.
Results : Perceived stress was positively related to depressive symptoms among U.S. Chinese older adults.
RESULTS : Percentage body fat was similar among the ethnic groups in men , while Brazilians were higher than Japanese in women.
RESULTS : @percent@ having used herbal medicines in many ways.
RESULTS : @percent@ Maori and @percent@ non-Maori rated their health from good to excellent.
RESULTS : @percent@ men and @percent@ women had anemia.
RESULTS : @percent@ ( @number@ ) of caregivers reported significant depressive symptoms ( CES-D ≥ @number@ ) .
RESULTS : @percent@ of Blacks and @percent@ of Hispanics , compared with @percent@ of Whites ( p < @number@ ) , reported having LTCI coverage.
RESULTS : @percent@ of older people did not meet the recommended guidelines.
RESULTS : @percent@ of participants had adequate health literacy skills.
RESULTS : @percent@ of participants self-reported walking difficulties , @percent@ had slow gait , and @percent@ clinical gait abnormalities.
RESULTS : @percent@ of patients declared the cosmetic effect important.
RESULTS : @percent@ of residents had chopped texture and @percent@ mixed texture.
RESULTS : @percent@ of respondents reported SCD and @percent@ of those with SCD received regular care.
RESULTS : @percent@ of smokers reported purchasing cigarettes from cheaper sources.
RESULTS : @percent@ of the characters were rated @number@ years or older.
RESULTS : @percent@ of the crude DM prevalence increase is attributable to the population aging during the whole period.
RESULTS : @percent@ of the participants had premature skin aging , worsening after the age of @number@
RESULTS : @percent@ of the participants reported a moderate to high concern ( FES-I ≥ @number@ ) about falls.
RESULTS : @percent@ of the patients were employed after lung transplantation.
RESULTS : @percent@ of the sample were normal weight , @percent@ overweight , @percent@ obese class @number@ and @percent@ obese class ≥2 according to BMI.
RESULTS : @percent@ of the study population , were classified as sarcopenic.
RESULTS : @percent@ of the total variance in older people's subjective ill-health was due to country differences.
RESULTS : @percent@ of TRIM participants and @percent@ of control participants provided the highest PACIC ratings ; this difference was not significant.
RESULTS : @percent@ of veterans ( N = @number@ ) had a baseline diagnosis of PTSD.
RESULTS : @percent@ patients presented Oropharyngeal Dysphagia ( OD ) , @percent@ presented laryngeal penetration and @percent@ presented aspiration.
RESULTS : @percent@ ( @percent@ confidence interval ( CI ) @percent@ to @percent@ ) of people with HIV had at least one other physical condition.
RESULTS : @percent@ persons were malnourished or at risk of malnutrition.
RESULTS : @percent@ received no care ; @percent@ formal care ; and @percent@ informal care ( @percent@ received both ) .
RESULTS : Performance on the RAVLT Trial @number@ and AF were very similar to comparable groups studied previously ; CLSA sample sizes were far larger.
RESULTS : Performance tests were reciprocally correlated at baseline.
Results : Performance was based on a measure of speed and accuracy for each game.
RESULTS : Perfusion in the anterior cingulate cortex was significantly decreased in aMCI cases compared to controls for both conditions.
RESULTS : Perioral aging can be broken down into changes of the lip shape and changes of the lip surface.
RESULTS : Periostin expression is highest in the papillary dermis and downregulated during skin aging.
RESULTS : Persistent and emergent depression are significantly associated with fear of God , feeling wronged by God , and negative religious coping.
RESULTS : Persons who experienced adverse childhood events showed a faster 10-year decline in processing speed but only when depressive symptoms were experienced.
RESULTS : Persons with a high number of recent falls tended to be younger , and more likely to have Parkinson's or multiple sclerosis.
RESULTS : Persons with PD exhibited step length asymmetry throughout many adaptation and adaptive learning conditions.
RESULTS : Pes planus foot posture was associated with increased odds of hammer toes and overlapping toes.
RESULTS : PE was confirmed in @number@ cases.
RESULTS : PF increased with age , with changes being larger for children than adolescents.
RESULTS : Pharmaceutical policies are linked to a country's socioeconomics.
RESULTS : Pharmacists and physicians showed high agreement in the identification and on the type and causality of ADRs.
RESULTS : Pharmacists have high starting wages but flat wage trajectories.
RESULTS : PHLPP2-knockout hepatoma cells and hepatocytes from L-PHLPP2 mice showed normal initiation of insulin signaling , but prolonged insulin action.
Results : Physical conditions were a stronger predictor in lower than in higher educated individuals while the association did not change with age.
RESULTS : Physicians reported significantly higher overall confidence in their dementia care competency @number@ months post-training compared to pre-training.
RESULTS : Physiological dysregulation is significantly , negatively related to SES in both the United States and Taiwan , especially for males.
RESULTS : PiB retention in WML was lower than in NAWM ( p < @number@ @number@ % reduction ) .
RESULTS : Pilot study inter- and intrarater scoring reliability were high ( weighted kappa scores of @number@ and @number@ respectively ) .
RESULTS : Plasma glucose concentration was unchanged during exercise in CON but decreased in DM2.
RESULTS : Plasma levels of SP-A increased with age and in the older group in relation to smoking and COPD.
RESULTS : Plasma NGAL concentrations were significantly associated with age , male gender , smoking and waist circumference.
Results : Plasmodium knowlesi parasitemia correlated with age ( Spearman's correlation coefficient [ rs ] = @number@ P < @number@ ) .
RESULTS : PLF was significantly increased in SI along with the increased amplitude of N20m in the old subjects.
RESULTS : Polyacrylamide hydrogel was as effective as NASHA , and effectiveness persisted throughout the 12-month follow-up.
RESULTS : Polygonum multiflorum is widely distributed throughout the world and has been used as a traditional medicine for centuries in China.
RESULTS : Poly ( I : C ) induced MMP-1 , @number@ and @number@ expressions , which were dependent on TLR3.
RESULTS : Polypharmacy was reported in @percent@ ( n = @number@ ) , and hyperpolypharmacy in @percent@ ( n = @number@ ) of participants.
RESULTS : Poorer baseline thresholds were strongly associated with faster hearing deterioration.
RESULTS : Poorer delayed recall performance at baseline predicted a steeper increase in depressed affect over time.
RESULTS : Poorer life-space mobility was associated with higher prevalence of different dimensions of depressive symptoms.
RESULTS : Poorer OI in older adults without dementia was associated with increased risk of dementia.
RESULTS : Poor general health , the number of longstanding health conditions , and most types of longstanding health conditions were associated with productivity loss.
RESULTS : Poor quality of care increased the risk of long-term care placement , as expected , but high-quality care was not related to placement.
RESULTS : Population concentrations of PFOS dropped approximately @number@ ( @percent@ CI : @number@ @number@ ) percent each year over 2003-2013.
RESULTS : Positive rate of measles antibody was @percent@ ( 1800 / 2125 ) and standardized positive rate was @percent@ .
RESULTS : Post-dialysis plasma carbonylated protein levels were significantly increased compared to pre-dialysis levels.
RESULTS : Postmenopausal women showed a good overall vocal quality , with a Dysphonia Severity Index value of @number@
RESULTS : Postoperative complications included moderate and transitory pain ; patients reported no major complications or recidivisms during the follow-up period of two years.
RESULTS : Postoperative delirium occurred in @number@ participants ( @percent@ ) .
RESULTS : Postoperative delirium screening was found positive in @percent@ ( @number@ of @number@ ) of patients.
RESULTS : Postoperatively , the keratometric value of the steepest meridian increased significantly in Group @number@ ( p = @number@ ) .
RESULTS : Postoperative mortality , overall morbidity , and each type of postoperative complication increased with increasing age.
RESULTS : PP is increased in @percent@ ( 4th report ) or @percent@ ( KIGGS ) of the patients , respectively.
RESULTS : Practices invited @number@ people with dementia to participate , @number@ ( @percent@ ) agreed.
RESULTS : Preadipocyte secretomes showed greater variation between depots than did intracellular protein expression.
RESULTS : PreCI was classified in @number@ of @number@ ( @percent@ ) patients ( @percent@ CI , @number@ to @percent@ ) .
RESULTS : Predisposing factors for multimorbidity among disease-free population were smoking , physical inactivity , and BMI.
RESULTS : Preeclampsia was associated with a rise in plasma and placental levels of MBG.
RESULTS : Prefrontal regions and the anterior cingulate were the leading brain areas associated with apathy in AD and MCI.
RESULTS : Pregnant women exhibited a decreased maximum voluntary isometric activity for all postural muscles evaluated.
RESULTS : Preliminary analyses revealed a main effect in the use of everyday and advanced technology across the four participant groups.
RESULTS : Preliminary analysis revealed that negative emotional experience with dyslexia negatively impacts self-esteem.
RESULTS : Preliminary CAB-SR reliability and validity were determined using reliability , factor analytic and correlational procedures.
RESULTS : Preliminary data revealed VFE and PhoRTE groups demonstrated a significant improvement in V-RQOL scores.
RESULTS : Premenstrual physical and mental symptom domains had similar negative effects on ADL.
RESULTS : preoperatively , plasma esterase activity was significantly lower in patients who developed delirium compared with the remaining subjects.
RESULTS : Preoperative PSQI scores indicative of sleep disturbance were reported in @percent@ of patients.
Results presented that TBI induced increased bilateral and decreased ipsilateral effective connectivity in the episodic memory network in comparison with that of normal controls.
RESULTS : Pre-test phase results suggested significant differences between both devices in the group of older participants only.
RESULTS : Pretreatment with Hu-Yi-Neng significantly reversed the decrease in cell viability induced by H2O2 in SH-SY5Y cells.
RESULTS : Prevalence and frequency of alcohol use was high throughout the study , with more than @percent@ of participants reporting weekly alcohol intake.
RESULTS : Prevalence of any endocrine abnormality was @percent@ ( dyslipidaemia @percent@ , glucose intolerance / T2DM @percent@ , thyroid disorders @percent@ ) .
RESULTS : Prevalence of at least one chronic-use medicines among older adults was @percent@.
RESULTS : Prevalence of CR and LVH was @percent@ and @percent@ , respectively.
RESULTS : Prevalence of diabetes was @percent@.
RESULTS : Prevalence of DM medication use was @percent@ in China and @percent@ in India.
RESULTS : Prevalence of frailty varies from @percent@ ( Frailty Index ) to @percent@ ( Groningen Frailty Indicator ) depending on the tool used.
RESULTS : Prevalence of misuse was @percent@.
RESULTS : prevalence of neuropathy ( @percent@ ) and obesity ( @percent@ ) was high.
RESULTS : Prevalence of the CC genotype in study participants ranged from @percent@ to @percent@.
RESULTS : Principal axis factor analysis indicated that two factors should be retained.
RESULTS : Principal components analysis with varimax rotation reduced the 26-item scale to the 10-item PFS.
RESULTS : Prior to the step initiation , the older subjects showed strong synergies that stabilized COP displacement to forward perturbation of the support surface.
RESULTS : Prior-wave body weight status prospectively predicted onset of functional limitation , and the relationship showed a U-shaped pattern.
RESULTS : Probability of multimorbidity and probability of slow gait speed were already above @percent@ and @percent@ among sexagenarians.
RESULTS : Progressive decline in relative survival ratios was noted over time.
RESULTS : Proliferation potential and telomere length were decreased in aged ADSC compared to young ADSC.
RESULTS : Proliferation was significantly stimulated by HA whereas migration was not affected.
RESULTS : Proportions meeting PA recommendation were @percent@ and @percent@ when utilizing absolute and relative MVPA , respectively.
RESULTS : Pro-SFTPB nondetectable status was significantly associated with lung cancer risk [ OR = @number@ @percent@ confidence interval ( CI ) @number@.24-27.48 ] .
RESULTS : Protein digestibility was severely reduced in the CF group ( @percent@ of healthy subjects ; P < @number@ ) .
RESULTS : Protein pulse feeding was more efficient than protein spread feeding at increasing plasma postprandial AA concentrations , notably of essential AAs.
RESULTS : Protocol B was associated with significantly lower complication rates.
Results provide important insights on youth's economic well-being , financial literacy , individual experiences regarding aging out of foster care and independent living.
RESULTS provide initial indications that lifetime stable personality traits may influence brain health in later life through health-promoting behaviors.
Results provide molecular confirmation of the genetic overlap between SCZ and general cognitive ability , and may provide additional insight into pathophysiology of the disorder.
Results provide support for the notion that adjustment to loss may be linked to factors that precede actual loss.
RESULTS : Providing or receiving financial support increased the likelihood as well as number of physician visits.
RESULTS : PS-omega-3 supplementation resulted in @percent@ increase in the ability to recall words in the delayed condition.
RESULTS : Psychological distress was generally low and not associated with MCI or whether study partners provided support or not.
RESULTS : Psychophysical thresholds were revealed to be the most precise and least variable acuity measure.
RESULTS : Ptw increased gradually with the increase in age.
RESULTS : Pure tone average ( low ) accounted for significant but minimal amount of variance in measure of MMSE.
RESULTS : Qi deficiency syndrome ( QDS ) and internal dampness-heat accumulation syndrome ( IDHAS ) were dominant in all syndrome types.
RESULTS : QRT-PCR revealed that the relative expression level of lens crystallins in C57BL / 6 corneas were higher than in Balb / c corneas.
RESULTS : QT interval was prolonged in patients with elevated blood pressure or body mass index.
RESULTS : Questionnaires were returned from @number@ care home managers ( @percent@ ) .
RESULTS : QUS bone quality data for an underrepresented , non-Western pediatric population are presented for the radius and tibia.
Results : R2 increased in both obese and nonobese subjects , independent of weight variations.
RESULTS : Racial / ethnic disparities were not present for well-child visits or dental checkups.
RESULTS : RACP was successfully performed in all patients assigned to the RACP group.
RESULTS : Radiographic primary shoulder OA was detected in @number@ people ( @percent@ ) , and secondary OA in @number@ ( @percent@ ) .
RESULTS : Random-effects models were used to assess the pooled effect sizes of longitudinal changes in cognitive function associated with MetS.
RESULTS : Rasch measurement theory and traditional psychometric methods confirmed the reliability and validity of the scales.
RESULTS : Rates of chronic disease appeared higher overall for people with ID as compared to the general population.
RESULTS : Rates of persistence were stable over the life span , whereas rates of new onset and recurrence decreased with age.
RESULTS : Ratings for the feet were surprisingly low.
RESULTS : Ratings of memory by both patients and neurologists correlated well with standard neuropsychological measures of memory.
RESULTS : RBCLS measurements were available for @number@ HD patients.
Results : RBD was diagnosed in @percent@ of patients.
Results : Rd improved similarly ( @percent@ ± @percent@ , p < @number@ ) with both weight loss and exercise.
RESULTS : Readiness to participate in ACP varied widely across behaviors.
RESULTS : Real-time PCR results showed a sixfold significant reduction in the Ang1 / Tie-2 ratio during aging.
RESULTS : Real time PCR results showed that BET stimulated significantly the expression of RUNX2 , osterix , bone sialoprotein and osteopontin.
RESULTS : Recurrence was recognized in @number@ patients ( @percent@ ) within @number@ years after operation.
RESULTS : Reduced perfusion predicted poorer cognition and decreased cortical thickness.
RESULTS : Reductions in SV and tachycardic response were smaller with UT60 than with WT60 , in both younger and older subjects.
RESULTS : Regarding acceptance of Alzheimer's disease screening ( Section B ) a single factor structure fitted best.
RESULTS : Regarding cognitive assessment , the majority was classified as independent ( @percent@ ) , not requiring caregiver assistance to answer the questionnaire.
RESULTS : Regardless of the cognitive condition , over @percent@ of the individuals in each group had at least one comorbid disease.
RESULTS : Regional CBF was lower in group B than in group A in the posterior cingulate gyrus and the precuneus.
RESULTS : Regional differences accounted for @percent@ of the variation in PT service provision and @percent@ of OT service provision.
RESULTS : Regional growth acceleratory phenomenon and favorable growth changes were found in type A collapse where the facets were intact.
RESULTS : Regression analyses indicated that LZC values were strongly dependent on age.
RESULTS : Regression analyses indicate that ADHD diagnosis and ADHD severity were only negatively associated with cognitive functioning in the attention / working memory domain.
RESULTS : Regression analyses revealed that FMTCG partially mediated the relationship between caregiver burden and caregiver mental health.
RESULTS : Regression analysis reveals that tiredness decreases with age.
RESULTS : Regular follow-up was completed in @number@ subjects ( @percent@ ) , with a median period of @time@ .
RESULTS : Relationships with adolescent and adult grandchildren were associated with all four facets of SWB.
RESULTS : Relative time to peak increased with age in controls ( P < 0.020 ) .
RESULTS : Relative to heterosexual women , lesbian / bisexual women showed higher cortisol stress reactivity @number@ min after exposure to the stressor.
RESULTS : Relevancy and clarity indexes of all items were more than @percent@.
RESULTS : Relevant data was available for @number@ ALSA participants.
RESULTS : Reliability for the composite LSA score was substantial ( ICC = @number@ @number@ % CI @number@.49-0.83 ) in Manizales.
RESULTS : Reliability was rated ' good ' in @number@ and @number@ infants respectively , for mirror distances and for the acuity cards.
RESULTS : Relocation was negatively associated with the number of social support resources that older adults perceived as being available.
Results remained highly significant in the multivariate models.
Results remained robust after adjusting for multiple potential confounders and accounting for normal-pace walking.
Results remained significant controlling for age , gender , education , ApoE , and total intracranial volume.
Results remained similar in sensitivity analyses.
Results remained similar when accounting for severity of cognitive impairment or disease duration.
Results remained similar when the serum measures were statistically adjusted for each other.
RESULTS : Remarkable lower expression levels of Klotho were observed in DLBCL patients and cell lines.
RESULTS : Remelted HXLPE qualitatively showed low oxidation indices ( ≤ @number@ ) when subjected either to cyclic loading or aging alone.
RESULTS : Remission occurred in @number@ ( @percent@ ) patients with completed follow-up assessments , while @number@ ( @percent@ ) did not remit.
RESULTS : Repeatability with regard to test-retest differences showed a mean limit of agreement of @number@ for whole digits and @number@ for half digits.
RESULTS : Repeated measure analyses of covariance revealed that greater age and MCI both significantly associated with slower gait speed , ps < .05.
RESULTS : reporting low / medium levels of social activity from mid-life to old age was the most common trajectory group.
RESULTS : Reports of previous-year suicidal thoughts decreased with age.
RESULTS : Research products increased from @number@ to @number@ ( approximately @percent@ ) .
Results : Residents ' mean age was @number@ years , @number@ ( @percent@ ) were African American , and @number@ ( @percent@ ) were women.
RESULTS : Residents of psychogeriatric units in nursing homes experienced low social engagement.
RESULTS : residents of RACF frequently presented severely unwell with multi-system disease.
RESULTS : Resilience and mastery were independently associated with psychological health-related quality of life.
RESULTS : Respiratory function declined significantly from @number@ to @number@ ( p < @number@ ) , but the mean annual changes were relatively small.
RESULTS : Respondents aged @number@ years or more were less likely than younger adults to endorse most of the GAD criteria.
RESULTS : Respondents averaged 68-70 years old , were well educated , had few physical dependencies , and had moderate incomes.
RESULTS : Respondents chose amoxicillin most frequently as an antibiotic , and clindamycin if penicillin allergy.
RESULTS : Respondents in poor health were older than those in good health ( @number@ vs. @number@ p ≤ @number@ ) .
RESULTS : Respondents ( N = @number@ ) had a median age of @number@ years ( range = 45-90 ) .
RESULTS : Respondents were generally accepting of low risk observational studies and slightly less accepting of low risk randomised trials of medicinal products.
RESULTS : Responders to treatment had less impairment ( P < .001 ) than nonresponders.
RESULTS : Response rates for maximum frown were @percent@ in the NTC group and @percent@ in the onabotulinumtoxin A group at week @number@
RESULTS : Response rates to initial postal invitations were low ( 526 / 1550 , @percent@ ) .
RESULTS : Response rate was @percent@.
RESULTS : Responses from GPs suggested that many patients with depression or anxiety may not be referred.
RESULTS : Responses from @number@ clinicians from @number@ different countries were analyzed.
RESULTS : Responses from @number@ students ( @percent@ of relevant classes ) were available.
RESULTS : Responses were collected from @number@ persons ( response rate = 68·8 % ) .
RESULTS : Responses were obtained from @number@ MDs , @number@ PhDs , and @number@ NPs.
RESULTS : Response to treatment was defined as a @number@ or more point improvement in patient and investigator assessments.
RESULTS : response was @percent@ for the patient sample and @percent@ for the staff sample.
RESULTS : Resulting age trajectories from all diseases showed a strong minimum , which was hidden in total mortality.
RESULTS : Results also indicated that age , ISS and GSC score have an effect on the GOSE score.
RESULTS : Results demonstrated a similar negative relationship between MAP and CBF across both age groups.
RESULTS : Results for immediate and delayed recall indicated an age-related improvement for dated memoranda and no age difference for unknown memoranda.
RESULTS : Results from the Camberwell Assessment Needs Forensic Short Version evidenced that met needs were more prevalent than unmet needs.
RESULTS : Results indicate a facilitation of new learning that was evident six weeks after rote learning ceased.
RESULTS : Results of @number@ RCTs involving a total of @number@ patients were analyzed.
RESULTS : Results of regression analysis showed that significant factors influencing successful aging were post-traumatic growth and social support.
RESULTS : Results on Phantom and Volunteers scans showed that I-ADNI acquisition parameters were comparable with those one of the ranked-A ADNI scans.
RESULTS : Results : Participants had significantly poorer self-rated health and negative health conditions.
RESULTS : Results provided some support for \ "strict \ " factorial invariance of the episodic memory and mental status measures across ethnicity and gender.
RESULTS : Results provide partial support for CBT as a treatment for depressive symptoms ; however , memory training augmentation did not produce improvements.
RESULTS : RESULTS revealed a large ( mean d = @number@ ) age-related decrease in spatial performance on psychometric tests.
RESULTS : Results show a significant increase in knowledge about older adults ' risks related to their medication and alcohol use from pre- to post-test.
RESULTS : Results showed a differentiated pattern of fat-cognition relationship depending on fat localization and type of cognitive function.
RESULTS : Results showed a significant three-way interaction effect among exergaming , play type , and age group on older adults ' psychosocial well-being.
RESULTS : Results showed that exercise did not alter cognitive control.
RESULTS : Results showed that the Memory Clinic Group as a whole improved on this training on most scales.
RESULTS : Results showed that the prevalence of self-reported cataract increased with age and was significantly higher in older women than in older men.
RESULTS : Results show that assessment of levels of root resorption was excellent ( Kappa @number@.88-0.94 ) .
RESULTS : Results show that each type of HA has a predictable histologic behavior in the skin.
RESULTS : Results show that in the earlier stages of AD , primary pathological foci are in the hippocampus and entorhinal cortex.
RESULTS : Results show that participants were involved in @number@ different leisure activities on average.
RESULTS : Results show that the older brain remains capable of showing sustained responses to light in several brain areas.
RESULTS : Results suggest that although qualitative errors do occur , they are relatively infrequent within a presumably cognitively normal sample.
RESULTS : Results suggest that OP , particularly with fracture , can have profound impacts on physical function / activity.
RESULTS : Results supported a longitudinal influence of grip strength on changes in cognitive function.
RESULTS : Resveratrol treated individuals showed a significant increase in tumor necrosis factor-α ( TNF-α ) levels 24h after treatment compared to baseline.
RESULTS : Resveratrol treatment has shown beneficial effects on glucose and lipid metabolism in some , but not all studies.
RESULTS : Retirees did not participate in their communities more than working people.
RESULTS : Retirees with the experience of repeated unemployment but not with one-time unemployment during working life reported worse mental health and satisfaction with life.
RESULTS : Retirement confidence is inversely related to parental history of cancer and cardiovascular disease but not to personal health history.
RESULTS : Retrieval-induced forgetting for names was observed in the YO group but not in the OO group.
Results reveal a strong relationship between positive aspects of the psychosocial work environment and improved self-reported health status , blood pressure , and cognitive function.
Results revealed a concern about the role , feasibility , and availability of case management for older adults within these settings.
Results revealed a different susceptibility to viewpoint changes in older than young participants.
Results revealed a more diffuse pattern of negative coherence-performance relations in older declined adults.
Results revealed an association between infants ' increasing knowledge of object use and maternal interpretations of infants ' gestures as conveying a clear communicative function.
Results revealed an interaction between age and APOE in a large cluster localized primarily to the bilateral precuneus.
Results revealed a significant effect of age group on feedback-based associative learning , consistent with evidence of persistent age-related declines in the basal ganglia.
Results revealed a significant group difference in the association between peak levels of cortisol and post task subjective stress.
Results revealed a significant interaction between social condition and type of communicative production.
Results revealed higher radial diffusivity in the anterior thalamic radiation among SOD2 CC genotypes compared to CT / TT genotypes.
Results revealed improvements in domain specific cognitive function in our sample.
Results revealed no quantitative changes of the capillary bed up to the age of @number@ years.
Results revealed poorer health , lower income and educational levels among Turkish than among Dutch elders.
Results revealed significant changes in upper body strength , leg strength , aerobic endurance , and body composition.
Results revealed significant moderate to large , negative effects of age on DA transporters and receptors.
Results revealed that age moderated the relation between pain catastrophizing and pain interference , with the strength of these effects declining with age.
Results revealed that better memory predicted shallower increases in functional limitations.
Results revealed that both infants ' and adults ' eye movements may be affected by holistic face information and demonstrated holistic face processing in 3-month-olds.
Results revealed that more-active adults had significantly fewer symptoms ( physical unstd.
Results revealed that older adults ' attitudes towards children improved significantly after their participation in the intergenerational program.
Results revealed that , overall , the rate of AMD documentation was @percent@.
Results revealed that parietal and occipital FBLs explained a significant portion of variance in EF.
Results revealed that perceived control is relatively stable in midlife , but starts to decline after midlife.
Results revealed that performance on the three lists was highly correlated and did not vary as a function of the order of presentation.
Results revealed that spacing enhanced learning beyond massed study.
Results revealed that very few randomized controlled trials exist on non-pharmacological management interventions for FTD.
Results reveal limited evidence for interaction effects between HIV and age on neuropsychological performance.
Results reveal several interesting , previously unknown , circadian patterns associated with human aging and gender.
Results reveal that about @percent@ of individuals from poor households face abuse of some kind , whereas only @percent@ of individuals from rich households do.
Results reveal that almost one-third of midlife and older gay men and lesbians maintain some fear of openly disclosing their sexual orientation.
Results reveal that early adversity contributes to more negative views of the past but rising expectations for the future.
Results reveal that nearly one-half of the sample revised their rating of childhood health during the 10-year observation period.
RESULTS : RFL-OA scores explained significant variance in suicide ideation , controlling for age , sex , depressive symptom severity , and loneliness.
RESULTS : RF produced noticeable clinical results , with high satisfaction and corresponding facial skin improvement.
RESULTS : Right and left eye functions were not significantly different from each other for either PVA or BCVA.
RESULTS : Right and left infarct groups had similar poststroke duration ( @number@ ± @number@ years ) , infarct size , and functional independence.
RESULTS : Risk factor data were available in > 96% and DXA in @percent@.
RESULTS : Risk of lower testosterone and higher LH and FSH levels was significantly increased for TCSs at all time points after RT or CT.
RESULTS : Risperidone , olanzapine and haloperidol showed a dose-response relation in mortality risk.
RESULTS : R max increased and the echogenicity decreased with age.
RESULTS : rMT was higher in OSAS than in RLS and controls.
RESULTS : ROC curve analysis showed that the fitness tests were good in diagnosing physical independence ( AUC > 0.7 ) .
RESULTS : Romanian older adults rate their health as \ "fair \ ".
RESULTS : Rotigotine proved beneficial on symptoms of anxiety in both patients , without worsening cognitive and behavioral symptoms.
RESULTS : RTL was distributed in the cohort with a mean ± SD of @number@ ± @number@
RESULTS : Rutin significantly inhibited the growth of LAN-5 cells and chemotactic ability.
RESULTS : S-ABR latencies , amplitudes , and sustained response mean data were obtained for younger adults and older adults.
RESULTS : Saccadic latency increased as stimulus size decreased in both groups.
RESULTS : safety.
RESULTS : Salivary progesterone level had significant positive correlations with oral mucosal epithelial MUC1 expression level and with salivary cortisol and DHEA levels.
RESULTS : Salivation significantly increased after consuming sorbet or water.
RESULTS : Samples from @number@ SCLC patients were analyzed.
RESULTS : Sarcopenia was identified in @number@ patients ( @percent@ ) .
RESULTS : Sarcopenia was present in @percent@ of the study population.
RESULTS : Sardinian elders self-rated lower levels of depression and cognitive failures and had greater levels of emotional competence.
RESULTS : SAT macrophage markers did not decrease with weight loss , but macrophage concentration may have increased , concomitant with improved IS.
RESULTS : SCD score demonstrated good construct validity compared to an existing measure of subjective memory and was partially explained by several lower-order measurements.
RESULTS : SCH and skin surface pH seemed to be unaffected by previous measurement procedures.
RESULTS : ScoliScore risk distribution in our population was @percent@ low risk , @percent@ intermediate risk , and @percent@ high risk.
RESULTS : SCRT treatment resulted in significantly decreased A549 cell growth and viability by induction of apoptosis.
RESULTS : Scull stripping and the extraction of the hippocampus data created a computerized model.
RESULTS : SDMT performance improved by @number@ points / test during the first six months and by @number@ points / test thereafter.
RESULTS : Searches resulted in @number@ included articles , describing @number@ QI sets with @number@ QIs.
RESULTS : Search yielded @number@ titles and abstracts from electronic databases and @number@ titles from hand searches , and @number@ studies met inclusion criteria.
RESULTS : Self-care or mobility limitations had a negative association with @number@ dimensions of well-being.
RESULTS : Self-efficacy was the only independent variable that consistently predicted all four exercise outcomes.
RESULTS : Self-esteem was correlated with age ( P = @number@ ) , but not with diabetes ( P = @number@ ) .
RESULTS : Self-neglect was associated with poorer cognitive function.
RESULTS : Self-rated health was a consistent predictor of mortality , but the respondent's expected health rating-10 years in the future-was an independent predictor.
RESULTS : Self-regulation of appetite involves a complex interaction between multiple domains , including cognitive , neural , social , and goal-directed behaviors and decision-making.
RESULTS : Self-report assessment of the context and type of ST is important but the tools tend to underestimate total ST.
RESULTS : Self-reported vaccination coverage was @percent@ ( @percent@ confidence interval : @number@.3-76.9 ) .
RESULTS : Self-reported walking speed was strongly associated with measured walking speed among men and women ( P < @number@ ) .
RESULTS : Semi-permanent fillers did not stimulate bacterial growth but they allowed bacterial colonization over the filler.
RESULTS : Sensitivity and specificity of informant-derived mood disorder diagnoses were related to patient personality.
RESULTS : Seroprotective influenza antibody titers ( ≥ 1 : 40 ) were observed in @percent@ HIV ( + ) and @percent@ HIV-uninfected women pre-vaccination.
RESULTS : Serum A-FABP positively correlated with body fat percentage , total cholesterol , serum triglycerides and erythrocyte sedimentation rate.
RESULTS : Serum AMH concentrations show a progressive decline with female ageing.
RESULTS : Serum AMH levels were more strongly correlated with AFCs than were serum levels of FSH , luteinizing hormone , and estradiol.
RESULTS : Serum AMH was above the detection limit in all samples with a marked variation according to age and pubertal status.
RESULTS : Serum concentrations of testosterone increased gradually with age by both methods.
RESULTS : Serum E2 ( @number@ vs. @number@ pg / ml ) was significantly lower in kidney stones patients compared to controls.
RESULTS : Serum estradiol was rapidly and uniformly suppressed on GnRHa.
RESULTS : Serum follicle stimulating hormone was significantly higher in males in the HT group ( P = @number@ ) than in the non-HT group.
RESULTS : Serum IgE was increased in allergic patients ( p = 0.0001 ) .
RESULTS : Serum IGF-1 concentrations were within the normal range ( mean @number@ nmol / l , standard deviation @number@ nmol / l ) .
RESULTS : Serum irisin levels were negatively correlated with age ( p < 0.001 ) and not associated with the VO2peak or HOMA-IR.
RESULTS : Serum lycopene increased in a dose-dependent manner after 8-week supplementation ( P < 0.001 ) .
RESULTS : Serum magnesium levels were within normal range in all patients , whereas intra-erythrocyte magnesium measurements were low in @percent@ of the patients.
RESULTS : Serum PCSK9 concentrations were significantly increased with aging.
RESULTS : Serum resistin levels were higher in type @number@ diabetic patients compared with the controls ( P < 0.01 ) .
RESULTS : Serum sclerostin levels varied significantly by season ( P < @number@ after adjustment for sex ) .
RESULTS : Serum sclerostin levels were higher in boys as compared to girls and declined in both sexes following the onset of puberty.
RESULTS : Serum sRAGE and AGEs levels were significantly higher in critically ill patients , compared to normal controls ( P < 0.05 ) .
RESULTS : Serum TXB2 levels were correlated with VEGF ( p < 0.05 ) .
RESULTS : Serum VEGF levels in AD patients with depression were significantly higher than AD patients without depression or the control.
RESULTS : Seven biomarkers were selected in accordance with a certain load standard.
RESULTS : Seven branched chain amino acid-related metabolites were found to be associated with both muscle CSA and the FFMI.
RESULTS : Seven cohort studies and @number@ randomized controlled trials ( RCTs ) were included in this meta-analysis.
RESULTS : Seven cross-sectional studies comprising @number@ participants were included.
RESULTS : Seven days after the last procedure , an increase in skin thickness was observed in all patients.
RESULTS : Seven electronic databases were searched from inception to @date@ .
RESULTS : Seven genes were associated with aβ in late middle age or change over time ; no associations were identified in old age.
RESULTS : Seven hundred eleven patients had radiographic signs of OA.
RESULTS : Seven hundred ninety-four articles were identified , and @number@ ( @number@ fetuses at risk for CoA ) articles were included.
RESULTS : Seven hundred sixty-three ( @percent@ ) participants met criteria for MetS.
RESULTS : Seven hundred thirty patients underwent procedures using fractional lasers in our center.
RESULTS : Seven individual haematologic malignancies which met criteria were identified.
RESULTS : Seven of ten patients showed response to treatment.
RESULTS : Seven out of @number@ clients ( @percent@ ) endorsed the quantitative item measuring suicidal ideation.
RESULTS : Seven patients ( @percent@ ) became shunt-independent before adulthood.
RESULTS : Seven patients ( @percent@ ) were males and @number@ patients ( @percent@ ) were females.
RESULTS : Seven patients presented a severe generalized RDEB phenotype ( RDEB-sev-gen ) , while the other @number@ suffered from milder phenotypes.
RESULTS : Seven patients were lost to follow up , leaving @number@ evaluable subjects.
RESULTS : Seven patients with a mean age of @number@ years and computed tomographic scans on average @number@ years apart were included.
RESULTS : seven patients with @number@ ulcers , nine of which received the described treatment , were enrolled.
RESULTS : Seven relevant studies were retrieved.
RESULTS : Seven studies involving @number@ patients ( completed LCR , n @number@ and COS , n @number@ ) were included.
RESULTS : Seven studies met inclusion criteria ( N = 1115 ) .
RESULTS : Seven studies met the inclusion criteria.
RESULTS : Seven studies were finally included in the meta-analysis.
RESULTS : Seventeen coding exonic variants were significantly associated with disease.
RESULTS : Seventeen patients were included ( all female , mean age @number@ years ) .
RESULTS : Seventeen patients with active CH , @number@ with inactive CH , and @number@ control individuals were evaluated.
RESULTS : Seventeen percent of our sample reported being caregivers.
RESULTS : Seventeen reviews on @number@ behavioral determinants of PA were eligible for this umbrella SLR.
RESULTS : Seventy analyses in @number@ studies were included in the systematic review ; @number@ of these were included in the meta-analysis.
RESULTS : Seventy-five participants were randomised ( IC n = @number@ GS n = @number@ GM n = @number@ ) .
RESULTS : Seventy-five-year-olds examined in 2005-2006 had higher values on extroversion and lower values on the Lie scale compared with those examined in 1976-1977.
RESULTS : Seventy-four Belgian nursing home residents ( @percent@ of women , @number@ ± @number@ years on average ) were included in this study.
RESULTS : Seventy-four veterans were admitted @number@ times.
RESULTS : Seventy percent conceptualized healthy sleep as an unbroken U shape and @number@ year olds were depicted with deeper sleep than @number@ year olds.
RESULTS : Seventy personalized and @number@ collective participation needs were reported related to daily and social activities.
RESULTS : Seventy-seven patients ( mean age @number@.5±6.4 years , sex ratio @number@ [ male / female ] ) were analyzed.
Results Seventy-seven ( @percent@ ) patients were positive for AMA-M2.
RESULTS : Seventy SRs were included ( @number@ paper-based and @number@ Cochrane SRs , respectively ) .
RESULTS : Seventy-three ( @percent@ ) of @number@ cases were taking daily medication for ET.
RESULTS : Seventy-two articles were reviewed.
RESULTS : Seventy-two patients were examined.
RESULTS : Seventy-two ( @percent@ ) of the @number@ participants met the MFC definition for frailty and @number@ ( @percent@ ) met the SPPB definition.
RESULTS : Seventy young and @number@ elderly cases were enrolled.
RESULTS : Several classes of linear mixed models evaluated whether cognitive decline increased per additional year closer to death.
RESULTS : Several factors were related to physicians ' adherence-predictions , including physicians ' perceptions of patient-agreement regarding treatment.
RESULTS : Several factors were significantly connected with PLO at ages @number@ @number@ @number@ and @number@
RESULTS : Several gait measures were worse in older compared to younger adults under all walking conditions ( p < 0.005 ) .
RESULTS : Severe shoulder pain was common in the study group , reported by @percent@ of all participants.
RESULTS : Sex , age , ethnicity , and persistent pain were independently associated with failing the visual field test in multivariate analysis.
RESULTS : Sexual thoughts / fantasies and sexual interest / desire / spontaneous morning erections emerged quickly and plateaued after @number@ weeks.
Results shed light on the orientation and magnitude of adiposity and metabolic markers in preventing muscle mass loss.
RESULTS : Shorter TL with increasing age was only observed in women who experienced child mortality ( p = @number@ ) .
RESULTS : Short-term mortality ( @number@ deaths ) was significantly associated with reduced eGFR only in patients with chronic ischemic heart disease.
Results show a direct relation between NL estimation performance and the amount of the activation in key areas for arithmetical processing.
Results show an improvement of up to 10%-20% using this approach compared to the classification performance obtained when using each individual data source.
Results show an increment of pro-inflammatory cytokine interleukin ( IL ) -1β secretion and caspase-1 activation during the senescence of endothelial cells induced by bleomycin.
Results show a significant improvement of three cognitive features after performing the NFT : visual perception , expressive speech , and immediate memory.
Results showed a decrease in a total number and the number of proliferating cells nuclear antigen-positive fibroblast-like cells in dermis with progression of age.
Results showed a deficient priming effect in AD patients when it was measured by an Identification of Fragmented Pictures task.
Results showed aesthetic improvement for all patients.
Results showed a greater Stroop interference in older than in young adults.
Results showed an overall reduction in postural sway across all participants from pre- to post-intervention.
Results showed an own-age bias for 7- to 9-year-old children and adults.
Results showed differences related to age in the healthy individuals and specific functional dissociations in the brain-damaged patients.
Results showed different effects of the co-variates across the three drug classes , and short half-life benzodiazepines were not associated with any neuropsychological measure.
Results showed improvement in recognition scores over four list administrations for the accented stimuli but not for the native English stimuli.
Results showed older grandmothers experienced less emotional and caregiving strain relative to younger grandmothers.
Results showed pronounced age-equivalent gains on the criterion task.
Results showed pronounced training-related improvements on the criterion updating task ( p < @number@ ) .
Results showed significant deterioration in destination memory , cognitive theory of mind and affective theory of mind in the older adults.
Results showed significant differences between the @number@ gels in all the tests.
Results showed significantly higher reaction times and error rates for older participants.
Results showed that acculturation factors were not associated with depression.
Results showed that age affects these two components.
Results showed that aging time was correlated with the concentration of some key aroma compounds and mannoproteins in Albariño wines.
Results showed that attachment avoidance was uniquely associated with lower perceptions of reward , whereas attachment anxiety was uniquely associated with stronger perceptions of threat.
Results showed that bilinguals outperformed monolinguals at the first testing session and across time both in episodic memory recall and in letter fluency.
Results showed that both groups produced comparable muscle mechanical work , though shared differently among muscles.
Results showed that both younger and older adults improved discrimination thresholds and RTs with similar learning rates and magnitudes.
Results showed that CP11 is stable at acidic pH showing a possible advantage for oral delivery due to the longer permanence in the stomach.
Results showed that decision tree classifier was able to reach @percent@ of classification accuracy using @number@ tags and @number@ mm standard deviation of noise.
Results showed that DistEn correctly ranked the complexity of simulated chaotic series and Gaussian noise series.
Results showed that , first , temporal pressure modified movement synchronization ; the finger extension preceded swing heel-off in RT , and inversely in SI.
Results showed that frequency of PVI was positively associated with memory scores for abstract words , but not faces.
Results showed that individuals with a higher level of depressive symptoms had shorter LTL.
Results showed that in the TFT SART only the older group exhibited a vigilance decrement.
Results showed that lack of initiative was closely related to lack of interest ( Study @number@ ) .
Results showed that larger NE was associated with greater cognitive decline @number@ months later , reliably classifying participants into decliners and nondecliners.
Results showed that mildly disturbed sleep the week prior and month prior to cognitive testing was associated with reduced working memory on cognitive evaluation.
Results showed that misestimated crossing times were related to the individual time base , with stronger time distortions in some older participants.
Results showed that more vulnerable cognitive components were related to executive functioning and in a lesser degree to processing speed.
Results showed that non-users reported higher levels of burden post-intervetion , and frequent users showed post-intervention reduction in experienced burden.
Results showed that @number@ × 10⁻¹-10 μM tenuigenin significantly promoted cell viability and reduced cell death.
Results showed that : ( @number@ ) For all noise levels , the SNR of ts-ASL was higher.
Results showed that older adults had preserved lipreading abilities when the visual input was clear but not when it was degraded.
Results showed that older adults had slower reactions than the young across all experimental conditions.
Results showed that older adults were physically able to produce fast primary submovements and that they demonstrated similar movement-programming capacities as young adults.
Results showed that PARP-1 inhibition under normal culturing conditions accelerated the rate of telomere shortening.
Results showed that @percent@ were correctly assigned to age class using this method.
Results showed that PKCF has antiaging effect on Drosophila.
Results showed that positive processing was negatively related to neuroticism and predicted well-being even after controlling for the average valence of past events.
Results showed that prior knowledge increased recollection in both age groups such that older adults recollected significantly more 1950s actors than younger adults.
Results showed that proverb interpretation accounted for a significant amount of unique variance of functional ability scores.
Results showed that QCZ NPs had considerably more effective antibacterial activities than Qe or CdSe nanoparticles ( CdSe NPs ) .
Results showed that relaxin promoted myogenic differentiation , migration , and activation of matrix metalloproteinases ( MMPs ) of cultured myoblasts in vitro.
Results showed that resequencing of this region resulted in @number@ candidate genes with potentially functional differences between strains.
Results showed that sample sizes required to achieve acceptable power of @percent@ are practically feasible , especially when using within-subject designs.
Results showed that the aged individuals ' statements about active aging are permeated with positive contents.
Results showed that the amplitude of factors representing the early and late N1b component was substantially larger after tetanic stimulation.
Results showed that the antioxidative ability of Gnaq-SY5Y cells was significantly improved.
Results showed that the average score for the MFES , some parameters of blood chemistry , and joint ROM were significantly improved after low-impact intervention.
Results showed that the contribution of age to different diseases was varied.
Results showed that the effect of vitamin D on falls followed a U-shaped curve whether analyzed by dose or serum 25OHD levels.
Results showed that the expression of both SIRT1 and FOXO3a were increased.
Results showed that the high EF group benefitted from increased effort in both tasks.
RESULTS showed that the learning parameters were positively correlated with the initial level and linear slope of subjective organization.
Results showed that the major predictors of needing formal care in elderly Taiwanese were old age , cognitive impairment and functional disability.
Results showed that the maximum lean angles of younger adults were @percent@ greater than middle-aged adults and @percent@ greater than older adults.
Results showed that the plasma thiols concentration decreased gradually during aging process , and the p-values between all three groups are less than @number@
Results showed that the repertoire of strategies was significantly smaller in older than in young participants.
Results showed that the total phenolic content of RPP was @number@ mg gallic acid equivalents ( GAE ) / g extract.
Results showed that the twins described themselves from the point of differences in relation to the co-twin.
Results showed that to be true even after controlling for the higher rates of co-morbidities among older patients and variations across hospitals in practice patterns.
Results showed that using a service dog increased the distance covered by the MWC users and also significantly decreased shoulder pain and intensity of effort.
Results showed that valence of semantic self-images , but not episodic autobiographical memories , was highly correlated with well-being , particularly in older adults.
Results showed that with increasing age , participants performed better on the task.
Results showed that young subjects had consistently larger pupils than older subjects for dark adaptation and during all light exposures.
Results showed the expected age-related decline in episodic memory performance , coupled with a relative preservation of semantic memory in older adults.
Results showed widespread age-related global and subregional atrophy , as well as some notable subregional expansion.
Results show emotion recognition deficits exist for the amnestic subtype with impairment in multiple domains , with an emotion-specific deficit for anger recognition.
Results showing the same trend were found for all MS components except glucose concentration.
Results show non-linear residual stress profiles across wall thickness , influenced by structural and mechanical parameters.
Results show that Abhd11os overexpression produces neuroprotection against an N-terminal fragment of mutant huntingtin , whereas Abhd11os knockdown is protoxic.
Results show that ADAS affects driving.
Results show that caregiving caused a disruption in workers ' functioning mainly by being absent , leaving work early , and coming to work late.
Results show that celebrities can trigger moral discussions among the nursing home residents.
Results show that celebrities can trigger moral discussions among the nursing home residents.
Results show that classroom training is not effective in making participants independent of benefit receipt.
Results show that cognition is complexly determined by multiple disease substrates.
Results show that except for object velocity and occlusion distance , occlusion duration was a critical constraint for infants ' reaching behaviors.
Results show that , in general , the number of attachment figures decreases in old age.
Results show that instantaneous complexity is able to effectively track the system dynamics and is not affected by statistical noise properties.
Results show that patients make significantly more errors than controls when identifying overlapping shapes , which correlate with reduced processing speed.
Results show that people with ID were earlier and more severely frail than people from the general population.
Results show that research has emerged from being technology-focussed to scenario-based taking different scientific perspectives into account.
Results show that similar to face perception , delayed face recognition was consistently facilitated by LSF content.
Results show that T₂ ( APP ) is able to discriminate between osteoarthritic and osteoporotic bone samples.
Results show that TF-SPE can be useful in examining potential risks associated with contaminated soils and to test effectiveness of remediation efforts.
Results show that the cognitive functioning of old rats is more affected by an impoverished environment than young rats.
Results show that the majority of teachers make use of early exit schemes.
Results show that the maximum tolerated dose of sildenafil citrate administered daily for @number@ weeks does not affect hearing in the mouse.
Results show that the presence of others influences the experience and expression of pain in older persons.
Results show that thresholds were higher for the two L2s groups than for the L1s.
Results show that time of testing modulates age-related differences only in the ability to resist automatic and prepotent responses.
Results show that women report lower marital happiness , marital interaction , and marital power than do men , on average.
RESULTS : SHS-attributable healthcare costs totalled over $ 241 million.
RESULTS : SIF ranged from @number@ to @number@ arbitrary units and was log-normally distributed.
RESULTS : Significant age and regional differences in Ascaris lumbricoides and Trichuris trichiura infection were detected.
RESULTS : Significant age and treatment effects were found.
RESULTS : Significant Age × AUD interactions were found across several prefrontal white matter regions ( R ( @number@ ) Δ = 5%-9% ) .
RESULTS : Significant age-dependent changes were found in the evenness of the surface reflection and in the intensity of the subsurface reflection.
RESULTS : Significant age-related trends were observed for frequency , position , and amplitude of dominant alpha peaks.
RESULTS : Significant brain region-specific differences in BDNF expression were found among the rats in different groups.
RESULTS : Significant correlations ( coefficients @number@.60-0.85 ) of gestational age , number of painful procedures and morphine exposure with brain volumes were observed.
RESULTS : Significant decline in physical function was observed ( p < @number@ ) .
RESULTS : Significant differences between the @number@ sample groups were observed in the pattern of physical surface alterations.
RESULTS : Significant differences in mean cartilage T2 values were observed between joint compartments.
RESULTS : Significant differences in the performance of aged and young adults were detected in both language and visuospatial memory tests.
RESULTS : Significant differences were found for some of the SELS parameters.
RESULTS : Significant disadvantage in OS and DSS was found with increasing age.
RESULTS : Significant effects of age and education were observed , but no interactions among the demographic variables were seen.
RESULTS : Significant effects of ceramic conditioning , cement type and storage conditions were observed ( p < @number@ ) .
RESULTS : Significant genotype-by-disclosure interaction effects were observed on several memory rating scales and tests of immediate and delayed verbal recall.
RESULTS : Significant improvement in P3 latency was found in exercising groups.
RESULTS : Significant improvements for all better health and better health care outcome measures were observed from baseline to 12-month follow-up.
RESULTS : Significant improvements in facial appearance could be observed as early as @number@ weeks , with continued improvement over the duration of the study.
RESULTS : Significant improvements in recognition performance due to processing were observed for the SPIN and QSIN.
RESULTS : Significant interrater agreement was found in the subscores of the four main sections of the NOPPAIN and also in the total score.
RESULTS : Significantly faster recovery of TEWL was seen on the PRP-treated side.
RESULTS : Significantly greater improvement was observed in both HBTX-A groups in comparison with the placebo group ( p < @number@ ) .
RESULTS : Significantly more residents with than without dementia are completely or to a great extent care dependent ( @number@ vs. @number@ % ) .
RESULTS : Significant main effects were found for both BMI and race / ethnicity , indicating that cognitive function varies significantly by both.
RESULTS : Significant negative correlations were found between the age of subjects and R2 , R3 , R7 , R8 and F3.
RESULTS : Significant negative correlation was observed between age and T2 / ADC mean values.
RESULTS : Significant reductions of local volumes on the brain surface were detected in frontal and temporoparietal areas in the BN compared with control participants.
RESULTS : Significant relationships were found between perceived stress / depression and hypertension.
RESULTS : Significant tissue reduction was observed bilaterally in the amygdala and hippocampus of schizophrenia patients.
RESULTS : Significant worsening occurred in all age groups on all outcomes over time.
RESULTS : Similar to previous studies , a sensitivity window on the order of a few hundred milliseconds was observed with all listeners.
RESULTS : Simulated cataract significantly impaired performance across all cognitive test performance measures.
RESULTS : Simultaneous exposure to polydatin and resveratrol produced synergistic antiproliferative effects compared with single compound treatment.
RESULT ( S ) : Single-year-specific median , mean , and SD values are summarized in Table @number@
RESULTS : Single-year-specific median , mean , and SD values have been evaluated for the Beckman Access AMH immunoassay.
RESULTS : SIRT1 expression was down-regulated in doxorubicin induced cardiomocyte injury , accompanied by elevated oxidative stress and cell apoptosis.
RESULTS : SIRTs are involved in proliferation and differentiation using NAM in BE ( @number@ ) -C cells.
RESULTS : Sit and reach test scores significantly increased ( @percent@ ) from baseline to week @number@ ( P < @number@ ) .
RESULTS : SIVD patients showed lower memory performance than both control groups for neutral as well as for negative words.
RESULTS : Six articles met the inclusion criteria and are analyzed in this review.
RESULTS : Six focus groups were conducted , involving @number@ women ( @number@ White , @number@ Black , @number@ Latina ) .
RESULTS : six hundred and eighty-six questionnaires could be analysed.
RESULTS : Six hundred and sixty-eight eyes of @number@ persons ( @number@ male , @number@ female ) were included in the study.
RESULTS : Six hundred forty-seven 21-year-olds were engaged in care ; @number@ ( @percent@ ) were LTFU in the year after turning @number@ years.
Results : Six hundred thirty-two participants ( n = @number@ @percent@ female ) were examined.
RESULTS : Six independent case-control studies were included in the meta-analysis.
RESULTS : Six key themes were identified.
RESULTS : Six main barriers and three facilitators were identified.
RESULTS : Six of the seven treatment conditions induced perceivable color change ( ΔE > @number@ ) .
RESULTS : Six papers were identified reporting the use of @number@ different interventions with people with dementia.
RESULTS : Six potential covariates were found to be sensitive to T2D associations with performance on seven cognitive measures.
RESULTS : Six prospective cohort studies were identified involving @number@ cases and @number@ participants.
RESULTS : Six studies were included , all performed in surgical departments and all observational.
RESULTS : Sixteen articles were reviewed , including seven cross-sectional surveys , seven qualitative studies and two mixed-methods studies.
RESULTS : Sixteen hospitals from six regions of Italy participated , and @number@ questionnaires were collected.
RESULTS : Sixteen HTx recipients ( mean age @number@ years , @percent@ male ) completed the study.
RESULTS : Sixteen observational studies met the inclusion criteria.
RESULTS : Sixteen of the @number@ patients were affected by RBD.
RESULTS : Sixteen out of @number@ articles were included.
RESULTS : Sixteen proteins correlated with disease severity and cognitive decline.
RESULTS : Sixteen studies were identified with all but one conducted in a community setting.
RESULTS : Sixteen subjects completed the trial.
RESULTS : sixteen subjects were below the sex-specific 15th percentile of the cohort.
RESULTS : Sixty-eight eyes of @number@ cases with a mean age of @number@ ± @number@ years were enrolled in the study.
RESULTS : Sixty-eight surveys ( @percent@ ) were filled out.
RESULTS : Sixty-five percent of women reported incontinence ( mean age 59±10 years ) .
RESULTS : Sixty-five ( @percent@ ) subjects in the intervention group and @number@ ( @percent@ ) in the control group fell during follow-up.
RESULTS : Sixty-five subjects completed study requirements.
RESULTS : Sixty nine mothers ( @percent@ ) reported offering items other than breastmilk.
RESULTS : Sixty nine percent of user guides were rated ' not suitable ' and @percent@ were rated ' adequate ' for their suitability.
RESULTS : Sixty-one ALNDs have been performed in the study period.
RESULTS : Sixty one patients gave answers to the interview questions.
RESULTS : Sixty-one patients were included , of whom @number@ patients ( @percent@ ) developed postsurgical delirium.
RESULTS : Sixty-one percent of practicing senior surgeons performed within the range of the younger surgeons on all cognitive tasks.
RESULTS : Sixty-one percent of residents with advanced dementia were admitted to a SNF after their hospitalization.
RESULTS : Sixty-one ( @percent@ ) of the participants developed AD.
RESULTS : Sixty patients completed the trial and assessments , including a 6-month follow-up.
RESULTS : Sixty patients were recruited and completed both tests.
RESULTS : Sixty ( @percent@ ) and @number@ ( @percent@ ) failed in any domain of the ASQ-3 and Bayley-III ( < 70 ) respectively.
RESULTS : Sixty publications ( @number@ clinical studies / reports and nine reviews ) published from @date@ to @date@ in PubMed met the inclusion criteria.
RESULTS : Sixty-three percent of participants conceived within @number@ months.
RESULTS : Sixty-three respondents completed the survey ( response rate , @percent@ ) .
RESULTS : Sixty-two elderly patients were studied ( @percent@ men ) .
RESULTS : Sixty-two ( @number@ % ) of programs responded.
RESULTS : Sixty-two patients had @number@ iliac arteries treated with angioplasty and stent placement.
RESULTS : Sixty-two percent of patients developed aVSP , and @percent@ developed DCI.
RESULTS : sjTREC and TBP gene were detectable in all @number@ samples of peripheral blood.
RESULTS : Skin laxity and photodamage ( rhytides and texture ) showed significant improvement with combination MFU + AFL treatment.
RESULTS : Sleep actigraphy data were successfully collected from @number@ individuals.
RESULTS : Sleep deprivation resulted in longer TOJ thresholds , poorer speech perception , and poorer nonword reading compared with controls.
RESULTS : Sleep duration declined during early adulthood.
RESULTS : Slower gait speed was associated with elevated depressive symptoms both concurrently and two years later.
Results : Small microaneurysms presented increased expression of collagen IV , laminin , fibronectin , nidogen , and perlecan , along with basement membrane thickening.
RESULTS : Small to moderate statistically significant effects of the intervention on the potential mediators were found at nearly all follow-up assessments.
RESULTS : SMCs were associated with poorer performance on measures of executive function ( p = @number@ ) .
RESULTS : SNCA mice display significant motor deficits at 14-18 weeks of age compared to WT mice , which progress over time.
RESULTS : SNP at a concentration of @number@ mM induced cell death , shown by the MTT method at different time points.
RESULTS : Social age deadlines for childbearing were perceived more frequently for women than men.
RESULTS : Social dominance covaried with patients ' capacity for cognitive control and verbal fluency.
RESULTS : Social engagement was significantly associated with depressive symptoms.
RESULTS : Social networks were negatively associated with onset of ADL disability but not associated with progression.
RESULTS : Social / role activities limitations , depression , and communication with physicians improved significantly from baseline to 6-month follow-up.
RESULTS : Sociodemographic and comorbid health factors were significantly associated with sleep quality.
RESULTS : socioeconomic inequalities in life satisfaction were present in all welfare regimes.
RESULTS : Socioeconomic status ( SES ) , age , and cognitive function accounted for approximately @percent@ of the variance in ICT use.
RESULTS : SOC was assessed to have an independent effect on work ability.
RESULTS : Sodium content per @number@ kcal differed widely among the @number@ chains by food item , precluding generalizations across chains.
RESULTS : Some amino acids increased or decreased with age.
RESULTS : Some factors associated with survival were common to both genders , whereas some others appeared gender specific.
RESULTS : Some personality characteristics were consistently related to psychosocial aspects more often than physical aspects of HRQOL.
RESULTS : SO prevalence was @percent@.
RESULT ( S ) : Specific spectral differences were highlighted in the two experimental groups of oocytes.
RESULTS : Specimens with lower amounts of silica-treated fillers exhibited more variations in color than specimens with larger amounts of fillers.
RESULTS : Spindles were detected in @percent@ of in vivo matured oocytes and in @percent@ adjacent to the first polar body ( PB ) .
RESULTS : Spinous process length was @number@.8±4.6 mm ( L5 ) to @number@.9±3.9 mm ( L3 ) .
RESULTS : Spline models resulted in better fits for many temporal and parietal regions compared with the dichotomous models.
RESULTS : SPMs and SPM receptors were detected in the human brain.
RESULTS : Sputum cell distribution of healthy subjects aged ≥50 years was mainly composed of neutrophils.
RESULTS : Staining for PPARγ showed cytoplasmic and nuclear localization in the @number@ youngest subjects ( ages , @number@ and @number@ years ) .
RESULTS : Staining of endothelium-Descemet membrane with LZ / BB was faint but sufficient.
RESULTS : Stakeholders acknowledged teen pregnancy as an issue but lacked contextual information.
RESULTS : Stakeholders reported frailty , lack of transport and dependence on others as factors impacting health access of the elderly.
RESULTS : Standardized data were obtained for @number@ studies ( n = @number@ mean age @number@ ± @number@ years ) .
RESULTS : Standard multiple regression revealed that @percent@ of the variance in sense of competence was explained by the combination of the four predictors.
RESULTS : Standard outcome measures indicated that the program had little effect on health and well-being.
RESULTS : Start-up times were slower in the stroller and shopping cart conditions compared with the unloaded and shopping bags conditions.
RESULTS : Statin use increased from @percent@ in 1998-99 to @percent@ in @date@ .
RESULTS : Statistical analyses were performed using the Kruskal-Wallis test and Spearman correlation coefficient.
RESULTS : Statistical differences were detected in peak-to-peak mean amplitude and threshold measures among groups.
RESULTS : Statistically significant differences in estradiol ( E2 ) and testosterone were seen between the ovarian samples and the peripheral samples in all groups.
RESULTS : Statistically significant differences ( p < @number@ ) were observed among all QCMC categories for the variables analysed.
RESULTS : Statistically significant group-dependent regression was observed between VAVG and H-index.
RESULTS : Statistically significant increases in prevalence proportions were observed for most individual cancers , and most prevalence durations studied.
RESULTS : Storage modulus , loss modulus and tangent delta ( tanδ ) were plotted against temperature.
RESULTS : Strength , body composition , function , and wellbeing all significantly improved over the intervention.
RESULTS : Strength of ( A ) upper limb in comparison to ( non-A ) was @percent@ weaker.
Results stress the importance of incorporating ALA into the diet.
RESULTS : Stroke and neurodegenerative disorders account for most causes of epilepsy in older patients.
RESULTS : Stroke participants showed significant worsening than controls in all three QOL measures.
RESULTS : Stroke survivors used more assistive devices and received more personal assistance and had greater unmet need than stroke-free controls.
RESULTS : Strong correlation between MR skeletal age and chronological age was observed for both investigators , Pearson correlation R2 = @number@ for each.
RESULTS : Strong non-linear age trajectory of life quality is revealed by the growth curve models where the peak is achieved in the late 60s.
RESULTS : Structural equation models indicate a strong positive correlation between altruistic types of activities and actual volunteering.
RESULTS : Students showed improved attitudes toward the elderly across two of the three ASD dimensions.
RESULTS : Studied properties were influenced by amines.
RESULTS : Studies have shown that Polish centenarian women are characterised by a specific physique and android obesity.
RESULTS : Study 1 : Results indicate that apron control requires especially high levels of memory-load and processing speed.
RESULTS : Study 1 : The CNST completed by site coordinators showed good sensitivity ( @percent@ ) and specificity ( @percent@ ) .
RESULTS : Study results show an excellent correction of facial defects.
RESULTS : Subjective and objective analyses showed @percent@ and @percent@ improvement at the two-month evaluation , respectively.
RESULTS : Subjective closeness to family and frequency of contact with friends were negatively associated with suicide ideation and attempts.
RESULTS : Subjective health worsened over time albeit moderately.
RESULTS : Subjective memory worsening was experienced in @percent@.
RESULTS : Subjects exposed to essential lavender oil showed a significant reduction in HR after the injection as compared to the pre-injection HR.
RESULTS : Subjects ' mean ± SD age was @number@ ± @number@ yr at baseline and @number@ ± @number@ yr at follow-up.
RESULTS : Subjects ranged in age from @number@ to @number@ years , with a mean age of @number@ ± @number@ years.
RESULTS : Subjects who died during the follow-up had higher baseline plasma levels of VCAM-1 , sFas , and HGF.
RESULTS : Subjects with a higher level of education had more retained teeth than subjects with a lower level of education.
RESULTS : Subjects with decreased TMIG-IC scores included @number@ ( @percent@ ) men and @number@ ( @percent@ ) women.
RESULTS : Subjects with greater habitual physical activity retained a greater lean mass over the @number@ years of observation.
RESULTS : Subjects with LSC , DM , or both had significantly greater risks of death.
RESULTS : Subjects without AD initiated PIMs more frequently than those with AD ( @number@ vs. @percent@ , respectively ; p < @number@ ) .
RESULTS : Substitution of VA for CA changed the FRS category into the higher one in @percent@ of subjects.
RESULTS : Suburban cases were found to comprise a growing proportion of OCC incidence.
RESULTS : Successful return to donation rated at 49·1% and the deferral rate was 13·3%.
RESULTS : Sufficient physical activity affected self-rated health most significantly in both genders , whereas excessive alcohol consumption had no significant effect.
Results suggest an age-related FBL shortening in specific brain regions related to poorer EF and CPS performance among older adults.
Results suggest a need to focus on the health of aging offenders with a history of SUD , particularly African Americans.
Results suggest an opportunity for greater coverage regarding the role of physical activity in promoting cognitive health in popular media.
Results suggest an overall age-deficit in VSWM.
Results suggest centenarians look different than do even the oldest age range of most normative aging datasets ( e.g. , 85-90 ) .
Results suggest continued study is needed in actigraphy and C-reactive protein as means to index positive health.
Results suggested that by increasing P407 concentration , the gelation temperature decreases and viscosity increases.
Results suggested that the factors capable of influencing MCI differed profoundly between older men and older women.
Results suggested that the Old group showed an additional deficit in associative memory that was not mimicked by divided attention.
Results suggested that the PDQ-8 was also associated with other clinical scales of mobility , depression and cognition.
Results suggest future directions for testing of geroprotective therapies in humans.
Results suggest maximal brain development and measures of brain injury / atrophy jointly contribute to cognitive function in older people.
Results suggest that a brief version of the GPG can be administered reliably and that this short form has high test-retest and interrater reliability.
RESULTS suggest that a more intensive physical therapy regimen may be recommendable during out-patient rehabilitation for individuals with DS post-stroke.
Results suggest that anticipated support from children is related to older parents ' better self-rated health and fewer depressive symptoms in both countries.
Results suggest that Black men who are older and incarcerated appear to be more resilient than White men who are older.
Results suggest that both pre- and postretrieval processes independently affect PM age effects.
Results suggest that changes in audiovisual temporal perception extend beyond the first decade of life.
Results suggest that delta and alpha λ indices are good markers of the severity of CHF.
Results suggest that environmental arsenic exposure reduces the effectiveness of folic acid supplementation in preventing myelomeningocele.
Results suggest that events related to marriage were the most frequent important event domains mentioned by U.S. centenarians.
Results suggest that increases in income may lead to a greater improvement in self-rated health.
Results suggest that in the lack of sensory feedback cueing , DPN participants were highly unstable compared to controls.
Results suggest that many AFC concepts did not apply well in developing areas.
Results suggest that mildly elevated blood pressure is a marker for better health status in Polish centenarians.
Results suggest that MNA-SF with calf circumference may possess some basic characteristics of a comprehensive and universal geriatric screening scale.
Results suggest that older adults were more successful than younger adults at implementing both attentional deployment and positive reappraisal.
Results suggest that phonological capacities may serve as potential clinical targets through rehabilitative training.
Results suggest that sad affective states might dampen subjective age.
Results suggest that self-differentiation prevents the impact of negative age-related information on older adults ' self-esteem.
Results suggest that sex hormones organize structural connections , and activate the brain areas they connect.
Results suggest that social support has a similar association with nursing home entry for rural , suburban , and urban elders.
Results suggest that sociodemographic factors influence the conditions of life of women treated with radiotherapy for breast cancer in a significant way.
Results suggest that subjective memory is influenced by aspects of psychological well-being but is unrelated to objective memory in older African Americans.
Results suggest that the attentional demands of blind navigation are higher in older than young adults , as well as when obstacles are present.
Results suggest that the educational model as described in this article sets forth positive outcomes in the education of aging savvy social workers.
Results suggest that the majority of ADNA personnel interviewed perceive the collaboration experience to be positive.
Results suggest that the use of visual art in nursing education can add a new dimension to students ' experiences.
Results suggest that those aging with HIV are subject to decreases in cognitive functioning.
Results suggest the need to improve care access , especially among men and those losing a child.
Results suggest the possibility of using the morphometric method to determine an aging profile of latent palmprints on glass surface , aiming for forensic purposes.
Results suggest there is room for policy changes to achieve equitable access to all levels of nursing home services for minority elders.
Results suggest white players live @number@ months longer than their African-American colleagues.
RESULTS : Suicide risk was found in @percent@ of the sample.
Results supported both mechanistic theories of CR and the use of our general theoretical model.
RESULTS : Supporting the hypothesis , the interaction between functional disability and social engagement within the facility was found to be significant.
Results support that FTP reflects a higher-order construct that consists of @number@ interrelated components-Opportunity , Extension , and Constraint.
Results support the notion of different brain functional connectivity patterns associated with the dynamic range of temporal discounting in old age.
Results support the protective role of exceptional parental longevity in preventing decline in physical function , possibly via genetic mechanisms that should be further explored.
Results support the use of intervention programs focused on parental criticism to help reduce adolescents ' somatic symptoms.
Results support this operational measure of reserve.
Results support using global measures of neurocognition to describe cognitive status in the oldest old , and we provide normative comparisons to do so.
Results support using nonpathogenic surrogate organisms to validate beef carcass intervention efficacy.
RESULTS : Support was obtained for a 51-item PCS made up of two constructs , Palliative Care Practice and Palliative Care Knowledge.
RESULTS : Surface treatments significantly influenced the μSBS ( p < 0.001 ) .
RESULTS : Surgery remains as the cornerstone treatment for early breast cancer in the elderly.
RESULTS : Surgery was performed in @number@ patients , of whom @number@ patients had been previously operated on.
RESULTS : Surprisingly , we discovered that human denervated myofibers survive years of denervation after full and irreversible disconnection from their motor neurons.
RESULTS : Survival was higher for patients with non-Medicaid insurance compared with either uninsured patients or patients with Medicaid.
RESULTS : sVCAM , sE-Selectin and oxLDL were higher and RBCVmax / RBCVbaseline and %Hyper lower in HE , while %Nitro and FCD remained unchanged.
RESULTS : symptoms improved , to a similar extent , in both groups.
RESULTS : Systemic administration of ADAMTS-13 achieved significant amelioration of microthrombosis and improvement in neurologic performance.
RESULTS : S-Zn levels and Zn / Cu ratio were lowest in ≤6h sleep.
RESULTS : T1 lesion load emerged as the most significant predictor of P300 and N200 latency.
RESULTS : T2 relaxation times and thickness of the patellar cartilage significantly decreased ( p < 0.0001 ) with increasing chronologic age.
RESULTS : TA parameters showed differences among the @number@ groups for the CC and thalamus.
RESULTS : Taxonomy-based analysis showed that The relative abundance of Firmicutes , Tenericutes , and Actinobacteria was significantly lower in LVC than in UTC.
RESULTS : TDP-43 pathology was identified in @percent@ of the participants.
RESULTS : Tear meniscus values were significantly correlated with clinical examination results and dry eye syndrome.
RESULTS : Telomerase activity was greater in retreat participants at the end of the MBT retreat.
RESULTS : Telomere length was correlated significantly across all placental tissues.
RESULTS : Ten medical student / older adult pairs completed the project.
RESULTS : Ten of @number@ eligible patients consented over @number@ months [ all female , mean age @number@ years ( SD @number@ ) ] .
RESULTS : Ten participants ( @percent@ ) completed the trial and reassessments.
RESULTS : Ten patients from the BRRT group and @number@ from the control group completed the 12-month follow-up.
RESULTS : Ten patients ( mean age : @number@ years ) with AFFs were compared with @number@ matched TFFs.
RESULTS : Ten patients participated ( antipsychotic-naive = 4 ) .
RESULTS : Ten SRs with @number@ primary studies satisfied the inclusion criteria.
RESULTS : Ten subjects completed the 8-week study.
RESULTS : Ten women and one man ( median age = @number@ years , interquartile range = @number@ ) participated.
RESULTS : Terms are proposed for distinguishing between devices that induce skin injuries of different depths.
RESULTS : Testicular volume ( TV ) is tightly associated with both sperm and hormonal parameters.
RESULTS : Test version , assessment site , and estimated quality of education were significant predictors of performance on the NYU Paragraph Recall Test.
RESULTS : The 11-year incidence of functional disability was @percent@ ( @number@ cases ) .
RESULTS : The 16-week home-based post-exercise supplementation resulted in a @percent@ increase ( p = @number@ ) in lower limb muscle mass.
RESULTS : The 20-year cumulative incidence of VI was @percent@.
RESULTS : The 25-item Chinese version of Resilience Scale ( RS-CN ) was fully completed by @number@ Chinese older people.
RESULTS : The 30-day in-hospital mortality rate was @percent@.
RESULTS : The 30-day unplanned readmission rate to the index hospital from SNFs was @percent@ ( @number@ hospital readmissions of @number@ discharges ) .
RESULTS : The 3-month application significantly improved overall photoaging through decrease of the Larnier's score in the three groups ( P < 0.001 ) .
RESULTS : The 5-HT ( 2A ) R BP ( ND ) s decreased with age , a relationship best described by an exponential-decay regression.
RESULTS : the 5-year survival rate was @percent@ for participants with low morale , @percent@ for moderate and @percent@ for those with high morale.
RESULTS : The AAQ total score proved significant influence of gender , having children , self-perceived health , depression , and quality of life.
RESULTS : The ABC-6 and ABC-16 balance confidence scores were strongly correlated ( r = 0.969 ; p < 0.001 ; convergent validity ) .
RESULTS : The abovementioned procedure generated an interdisciplinary intervention model for preventing postoperative delirium that is applicable to the Chinese medical environment.
RESULTS : The absolute number of patients starting PD between @number@ and @number@ was stable at about @number@ per year.
RESULTS : The accumulation of LFLP increased during storage of all walnuts.
RESULTS : The accuracy of the four dynamometers measurements compared to known forces was excellent ( r > @number@ ) .
RESULTS : The Ach index showed a strong reduction in the severe stages of AD dementia.
RESULTS : The ACT group ( n = @number@ ) and control group ( n = @number@ ) had similar baseline characteristics.
RESULTS : The action spectrum peaked at @number@ nm followed by , in order of decreasing effect , @number@ @number@ @number@ @number@ and @number@ nm.
RESULTS : The ACTIVE sample is younger , more likely to be female , Black , and more highly educated than the HRS sample.
RESULTS : The adherence rate was @percent@ in the aerobic exercise group and @percent@ in the strength training group.
RESULTS : The adjusted OR for current use of BPs with respect to past use was @number@ ( @percent@ CI @number@ to @number@ ) .
RESULTS : The AET program was effective as indicated by significant improvement in aerobic capacity in all participants.
RESULTS : The age- and sex-standardized incidence rate of HF was @number@ per @number@ person years.
RESULTS : The age- and sex-standardized prevalence of hypertension significantly increased from @percent@ to @percent@ from the @number@ to the @number@ survey.
RESULTS : The age at assessment was @number@.1±1.9 years.
RESULTS : The age at surgery averaged @number@ years ; there were @number@ men and @number@ women.
RESULTS : The age group of 5-9 had the highest mortality and morbidity among children.
RESULTS : The age @number@ and older fall rate per @number@ discharges was @number@ while the mortality rate for those who fell was @number@
RESULTS : The age of participants in the main survey was @number@ ± @number@ years ( mean ± SD ) .
RESULTS : The age or gender was not significantly different between the intervention and control groups.
RESULTS : The age range of patients in this series was @number@ to @number@ years.
RESULTS : The age-related trend in bone and muscle coincided in men but not in women.
RESULTS : The age to reach the same cumulative incidence as women without family history decreased with decreasing diagnostic age of the affected relative.
RESULTS : the all-cause and dementia mortality differed by occupational class.
RESULTS : The ALP and BAP levels of people in their 80s were significantly higher than those of people in their 60s.
RESULTS : The alternative transcript smLRP1 is ubiquitously expressed in @number@ human cell lines of different origin and @number@ tissues which is similar to LRP1.
RESULTS : The amounts of GSSH , CysSSH and GSSSH were decreased in the lung cells and ELF from patients with COPD.
RESULTS : The AMP-RSMM correlation was equal to @number@ ( @percent@ confidence interval , @number@ to @number@ P < 0.001 ) .
RESULTS : The AMS scale and both QoL questionnaires of group I showed significantly worse median scores in all parameters.
RESULTS : The AMTS could successfully differentiate the dementia group from the non-dementia group.
RESULTS : The analyses were based on @number@ @number@ participants aged≥50 years at baseline.
RESULTS : The analysis considered @number@ patients < 75 years and @number@ patients > or = 75 years of age.
RESULTS : The analysis found that , compared to controls , KS patients showed the differential up- and down-expression of @number@ and @number@ transcripts.
RESULTS : The analysis included @number@ person-years of follow-up.
RESULTS : The analysis is based on @number@ participants.
RESULTS : The analysis leaned towards an overall positive evaluation of the clinical learning environment with more positive values for students considering a career.
RESULTS : The analysis of the scale's reliability showed good internal consistency ( α = @number@ ) .
RESULTS : The analytic cohort included @number@ @number@ nurses.
RESULTS : The analytic sample included @number@ older adults.
RESULTS : The anatomic structures of the neck district were visualized in 124 / 127 enrolled patients and pathological features were observed in @number@
RESULTS : The anatomy of the lower eyelid and the lid-cheek junction has to be understood as a unit.
RESULTS : The annualized incidence rate of clinically significant depressive symptoms was @number@ per @number@ person-year.
RESULTS : The annualized percent changes in hip , femoral neck , and vertebral BMD were similar across klotho quartiles.
RESULTS : The antecedents , defining attributes , and consequence of resilient ageing were identified.
RESULTS : The anterior border of the substantia nigra was defined by the crus cerebri.
RESULTS : The antioxidant power as well as the intracellular glutathione concentration first increased , reaching maximal values after one and two weeks , respectively.
RESULTS : The APOE epsilon4 allele and problems meeting BN independently predicted CD.
RESULTS : The app does allow measuring differences in neuromotor performance.
RESULTS : The application of an age-dependent D-dimer cut-off showed a now negative test-result in @number@ of @number@ patients ( @percent@ ) .
RESULTS : The approach allowed screening of a limited number of references ( range : @number@ to 406 / review ) .
RESULTS : The Area under the Curve , AUC ± SE was @number@ ± @number@ p < @number@ with @percent@ CI ( @number@.695-0.922 ) .
RESULTS : The ASCOT and the ICECAP-O tapped into a shared factor , whereas both measures also loaded on two separate factors.
RESULTS : The assay was linear for 17-hydroxyprogesterone , with a coefficient of determination > 0.997 and imprecision ≤ @percent@.
RESULTS : The association between auditory-perceptual assessment of voice and acoustic parameters was not statistically significant but showed less vocal quality deviations.
RESULTS : The association between numerous different cardiovascular disease risk models and cognitive outcomes has been tested , including Framingham and non-Framingham risk models.
RESULTS : The association between sleep duration and sarcopenia exhibited a U shape in older adults.
RESULTS : the associations between serum 25 ( OH ) D and carotid IMT or PWV were non-linear.
RESULTS : The author discusses many aspects of healthcare for the elderly.
RESULTS : The authors discuss traditional and fractional ablative lasers for achieving skin tightening.
RESULTS : The authors find no significant effects of alcohol consumption on either ER visits or hospital admissions among older adults.
RESULTS : The authors identified @number@ comprehensive palliative care competencies for medical students and IM / FM residents , respectively.
RESULTS : The available symptom assessment tools are useable , well validated , and in common use but not in the older patient population.
RESULTS : The average adipocyte size of nasolabial fat is significantly ( p < @number@ ) larger than that of deep medial cheek fat.
RESULTS : The average age of patients was @number@ years.
RESULTS : The average age of patients with OA was @number@ ( ±15.87 ) years and patients with RA was @number@ ( ±14.87 ) years.
RESULTS : The average age of the @number@ men was 67±10 years.
RESULTS : The average age of the participants was @number@ ± @number@ years.
RESULTS : The average age was @number@ the majority of the sample was African-American ( @percent@ ) .
RESULTS : The average annual Canadian MS mortality rate , 1975-2009 was @number@.23 / 100 , 000.
RESULTS : The average awareness rate over the 3-year study period was @percent@ in subjects with cataract and @percent@ in subjects with age-related macular degeneration.
RESULTS : The average career length is @number@ ± @number@ yr for the top @number@ men and @number@ ± @number@ yr for women.
RESULTS : The average CHADS2 score was @number@ ± @number@
RESULTS : The average cost associated with the use of health resources was @number@ , 922€ / year.
RESULTS : The average donor age was @number@ years ( standard deviation = @number@ years ; range , 55-93 years ) .
RESULTS : The average effect size of APOE ε4 status was non-significant across cognitive domains.
RESULTS : The average followup was @number@ years.
RESULTS : The average follow-up was @number@ years and the average IOP during follow-up was @number@ mm Hg with or without medication.
RESULTS : The average inmate ( N = @number@ ) age was @number@ ± @number@ years ; @percent@ were ≥50 years.
RESULTS : The average iodine intake of the group was @number@ ± @number@ μg.
RESULTS : The average LFA was @number@ ± @number@ mm2 in the control group and @number@ ± @number@ mm2 in the LCSS group.
RESULTS : The average monthly birth number was 306±60.38.
RESULTS : The average MPOD for the whole group was @number@ ± @number@ optical density units.
RESULTS : The average MPOD value was @number@ ± @number@ ( range @number@ @date@ ) .
RESULTS : The average number of cancer hospitalizations for radiologists from @number@ to @number@ ranged between @number@ and @number@.26‰.
RESULTS : The average patient age was @number@ years ( 36-73 years ) .
RESULTS : The average rate of overall technical efficiency ( OTE ) was @number@ in @number@ there was considerable variability by region.
RESULTS : The average serum vitamin D level was 176±79nmol / L in recurrent tonsillitis group and 193±56nmol / L in control group.
RESULTS : The babyboomer cohort ( 1946-1965 ) in Victoria is @number@ times larger than the cohort before them.
RESULTS : The Baltimore group had @number@ subjects with falls , @number@ frail subjects , and @number@ deaths.
RESULTS : The baseline demographic variables were comparable in both groups.
RESULTS : The baseline plasma ADMA concentrations , carotid arterial compliance , and most other key dependent variables did not differ between the @number@ groups.
RESULTS : The baseline sociodemographic and clinical characteristics of the @number@ groups were comparable.
RESULTS : The basement membrane remained intact after intraepidermal microablation , as demonstrated by laminin γ2 immunostaining.
RESULTS : The BA showed a more acute angle at the angulation point in the elderly patients than in the healthy subjects.
RESULTS : The BCE-treated explants showed significantly higher RPE nuclear density than did the control explants at all time points.
RESULTS : The BChE-K allele frequencies in the Thai community-dwelling patients were in accordance with other ethnics.
RESULTS : The bilingual proficiency score in all participants was within the range for early bilingualism.
RESULTS : The bipolar group had smaller overall and subregional callosal areas and correspondingly reduced callosal width than the control group.
RESULTS : The BTMs of postmenopausal women were 17-96 % higher than premenopausal women.
RESULTS : The buildup of stream segregation is slowed for both age groups when the masker is intact , colocated speech.
RESULTS : The burden of major cardiovascular disease risk factors did not significantly differ across tertiles of psychological factors.
RESULTS : The calculated incidence rate was @number@ cases per @number@ person-years with a median age of @number@ slightly lower than previously published data.
RESULTS : The California Verbal Learning Test ( CVLT ) immediate recall was the first measure to decline , followed by CVLT delayed recall.
RESULTS : The cancer cohort spent an adjusted $ 15 , 605 more over @number@ years than did the noncancer comparison group.
RESULTS : The care of individuals with dementia compels solid interdisciplinary collaborations.
RESULTS : The CASD scores indicated that GPs had a neutral attitude towards older people.
RESULTS : The CAS identified at least one alert in @number@ patient-days , i.e. , @percent@ of screened patient-days.
RESULTS : The caudate tail was imperceptible in @number@ % , had a nodular shape in @number@ % , and was flat in @number@ %.
RESULTS : The cecum was reached in @percent@ of patients.
RESULTS : The CE-MRA results were in all cases consistent with the DSA dataset.
RESULTS : The change in HbA1c was significantly reduced after @number@ months of therapy ( @number@.1%±0.8% to @number@.3%±0.2% ) .
RESULTS : The changes in MMSE score in response to the @number@ different treatments were not different.
RESULTS : The choroidal-scleral interface was visualized in @percent@ and @percent@ of the macular and peripapillary scans , respectively.
RESULTS : The clinical and delivered pregnancy rates were similar in younger donors vs older recipients following fresh embryo transfer.
RESULTS : The clinical and economic burden of osteoporotic fractures in @number@ is given for each of the @number@ countries of the EU.
RESULTS : The clinical population size varied by definition , increasing from @number@ 000-19 @number@ patients in @number@ to @number@ 000-26 @number@ in @number@
RESULTS : The cluster analysis suggested five categories for home-visit nursing agencies based on the type of service delivery system.
RESULTS : The coexistence of lacunes and large infarcts results in higher likelihood of clinical diagnosis of AD only when AD pathology burden is low.
RESULTS : The cohort ( aged @number@ ± @number@ years [ means ± SD ] ) had a mean A1C of @number@ ± @percent@.
RESULTS : The cohort comprised @number@ individuals with median pre-ART age of @number@ years , @percent@ women ; @percent@ Black , non-Hispanic ; @percent@ Hispanic.
RESULTS : The cohort consisted of @number@ T2D men with age @number@.6±5.8years , HbA1c @number@.5±0.97% , and @number@ ( @percent@ ) metformin users.
RESULTS : The cohort included @number@ @number@ First Nations and @number@ @number@ @number@ non-First Nations people aged @number@ years or older.
RESULTS : The cohort was @number@ % female and mean ( SD ) age was @number@ ( @number@ ) years.
RESULTS : The color categories showed a broad overlap in proliferative activity and hormone receptor expression.
RESULTS : The community is generally well adapted to heat with all having modified their homes and behaviours to cope with extreme heat.
RESULTS : The composition of encrustations at the proximal coil reflected the composition of stones in patients with urolithiasis.
RESULTS : The connections between hallucinations , mood disorders and negative symptoms are often difficult to live with for the nearest and dearest.
RESULTS : The consensus recommendations address general questions regarding treatment and provide specific guidelines on each common aesthetic indication.
RESULTS : The correlation between age and PI was observed significant only for the > 60 years cases.
RESULTS : The correlation between the PACSLAC and PAINAD was high ( r = @number@ [ @percent@ CI : @number@.67-0.87 ] ) .
RESULTS : The correlation coefficient between recalled and calculated max weight in the overall sample was @number@
RESULT ( S ) : The correlations among AFC , AMH , FSH , and age are statistically significant.
RESULTS : The cortical thickness measured with Freesurfer was systematically lower by one third if compared to Civet's.
RESULTS : The country-based survey included @number@ AKI patients ( 7604 / 374 , 286 , @percent@ ) .
RESULTS : The CPS provided monographs for @percent@ of the medications , and requests to manufacturers produced the remaining monographs.
RESULTS : The CR group achieved an average @percent@ ± @percent@ CR during the 2-yr intervention.
RESULTS : The critical ratio was not significantly different for either preferred or nonpreferred arms within and between groups.
RESULTS : The Cronbach’s alpha of the instrument was @number@
RESULTS : The Cronbach's α coefficient of the C-APQ was @number@
RESULTS : The cross-sectional analysis showed that with an increased level of physical activity , the reporting of poor or moderate work ability decreased.
RESULTS : The crude disability incidence ( at least one ADL ) was 27·1 / 1000 person-years in the period.
RESULTS : The cultured cells were identified to be NPCs.
RESULTS : The cumulative annual incidence of hospitalization was @percent@ ( @number@.5%-42.7% ) for DAL and @percent@ ( @number@.0%-12.6% ) for LTC residents with dementia.
RESULTS : The cumulative rate of post-treatment HBV relapse at @number@ years was @percent@.
RESULTS : The curative care expenditure for the aged was @number@ billion RMB.
RESULTS : The current mean body weight was significantly higher in all groups than at the age of @number@
RESULTS : The dance therapy program was reflected by a significant improvement of erythrocyte count and hematocrit.
RESULTS : The data analysis revealed the core category , \ "Self-determination - shifting between self-governing and being governed \ ".
RESULTS : The database search resulted in @number@ articles , of which five papers were included.
RESULTS : The database was constructed in @number@ and covers @percent@ of the Danish population.
RESULTS : The data demonstrated that compared with that in the adult patients , subcutaneous bacterial survival rate was higher significantly in the elderly.
RESULTS : The data from each phase informed the development and refinement of the computer-assisted instruction.
RESULTS : The data from @number@ societies contained in PANLAR consist of @number@ adult and @number@ pediatric rheumatologists serving @number@ million people.
RESULTS : The data presented a broad profile of the adult ostomy population in the United States.
RESULTS : The data showed that BMI is associated with decreased ΔAGE , i.e. , increased epigenetic age , in middle-aged individuals.
RESULTS : The data showed that sportsmen outperformed sedentary participants.
Results : The demographic characteristics of the groups were matched.
RESULTS : The depressed group consisted of @percent@ abstainers , @percent@ moderate drinkers , and @percent@ at-risk drinkers.
RESULTS : The depressed patients had deficits in cognitive planning / organization , working memory , and sustained attention compared to the healthy controls.
RESULTS : The development of the orbit structure followed a biphasic pattern.
RESULTS : The difference in life expectancy between older men and women has narrowed since @number@ but a gap remains.
RESULTS : The differences in cognitive functioning observed between the groups were related to specific nutrient intake , as was handgrip strength to some extent.
RESULTS : The direction and the way of cancer propagation in larynx anterior commissure structures is dependent on morphological changes that occur with aging.
RESULTS : The disability review identified @number@ studies and three main types of interventions : exercise , multi-component , and health screens.
RESULTS : The distribution of AKI causes was different between the age groups.
RESULTS : The distribution of genotypes did not differ between elderly patients and control subjects.
RESULTS : The dives slightly decreased lymphocyte number and significantly reduced lymphocyte H ( @number@ ) O ( @number@ ) levels.
RESULTS : The DJGLS proved to be internally consistent and to have adequate convergent validity among all ethnic groups.
RESULTS : The dominant side was affecting in @percent@.
RESULTS : The DTE was found to be feasible for completion by residents with assistance from staff.
RESULTS : The dyadic relational resources of mutuality and preparedness moderated the effects of caregiving demand on caregivers ' role strain.
RESULTS : The EDC treatment had no influence on the dynamic mechanical properties of the hybrid layer immediately after bonding.
RESULTS : The educational needs of each discipline related primarily to foundation level knowledge in major aged care topics.
RESULTS : The EFA revealed a one-factor structure that was equivalent across all racial groups.
RESULTS : The effect of age on the ability to accurately and rapidly repeat long , complex nonwords was significant.
RESULTS : The effect of self-reported sleep apnea on dementia risk depended on APOE ɛ4 status.
RESULTS : The effect of soybean accelerated aging on tofu sensory characteristics and acceptance was more pronounced compared to the natural condition.
RESULTS : The effects of stress and negative relationship quality were dyadic and varied by gender.
RESULTS : The efficacy of secondary fracture prevention programs correlates strongly with their intensity.
RESULTS : The EI showed a significant negative correlation with muscle strength ( r = @number@ P < @number@ ) .
RESULTS : The elderly adults showed significantly higher co-activation than the young and middle-aged adults during gait ( p < @number@ ) .
RESULTS : The elderly and female patients were prescribed significantly lower doses of zolpidem than their counterparts.
Results : The elderly individuals presented normal patterns in more than @percent@ of the appearance and mobility parameters.
RESULTS : The elderly requiring care had significantly lower intracellular water than did healthy elderly in the upper and lower legs.
RESULTS : The elderly were capable of stabilizing the COPAP coordinate based on co-varied involvement of the M-modes.
RESULTS : The electronic literature search yielded @number@ articles.
RESULTS : The emergency decompressive surgery was performed within @number@ hours ( median @number@ hours , range 6-28 hours ) after sustaining the head injury.
RESULTS : The emergency increase of bacterial resistance shows severe clinical and economical problems.
RESULTS : The E.M.I. score showed the highest anisotropy in neonates.
RESULTS : The employment of positive and negative feedback significantly modulated performance in a conflict task.
RESULTS : The endurance time in young men was significantly shorter than in young women.
RESULTS : The entire survey was completed by @number@ of @number@ respondents ( @percent@ ) .
RESULTS : The EQ-5D index score was higher for habitual tea drinkers than their counterparts.
RESULTS : The EQ-5D was applied to @number@ older people , of whom @number@ ( @percent@ ) had dementia.
RESULTS : The errors in controlled force exertion tended to increase constantly with age in both sexes.
RESULTS : The estimated average cost of caregiving per month was US $ 186.18 , @percent@ of which was direct cost.
RESULTS : The estimated normal average RNFL thickness change over time was @number@ ± @number@ μm / year ( P < @number@ ) .
RESULTS : The estimated prevalence of MCI was @percent@.
RESULTS : The estimation of the prevalence of underweight was @percent@ and that of overweight was @percent@.
RESULTS : The evaluation of cognitive impairment by MMSE showed a significant difference in the two groups ( p < @number@ ) .
RESULTS : The evidence base consisted of seven systematic reviews focused on Alzheimer's disease prevention and @number@ reviews focused on symptom management.
RESULTS : The evolution of glycaemic control is not linear and differs across all age groups.
RESULTS : The excess in all-cause mortality before age @number@ years in adoptees was estimated to be @number@ ( @percent@ CI @number@ @date@ ) .
RESULTS : The exercise group showed significant improvement in attentional shift over the course of the observation period including a 6-month follow-up.
RESULTS : The expected accumulated superannuation balances for two hypothetical individuals are estimated.
RESULTS : The expected values varied with menstrual age for all parameters.
RESULTS : The experience of dementia is not universal , but is profoundly shaped by culture in which the demented person lives.
RESULTS : The experimental group reported the highest QOL for every facet and the total score.
RESULTS : The experimental results showed that the separability of the samples was apparently improved.
RESULTS : The exploratory factor analysis confirmed the construct validity of the AAQ.
RESULTS : The exploratory factor analysis using ESEM revealed that the data fitted the proposed model.
RESULTS : The expression of ROS in tissues and cells which under hypoxic condition was significantly increased.
RESULTS : The expression of α-Klotho and FGFR1 was significantly reduced in the hyperplastic parathyroid tissue compared to that in the normal parathyroid tissue.
RESULTS : The factor analyses yielded seven factors for each test battery.
RESULTS : The factors related to higher cognitive function at the intercept included being younger , male , higher education , and doing unpaid work.
RESULTS : The factor structure for the limitation domain within the LLDI in the LIFE-P study did not corroborate previous findings.
RESULTS : The FA values of left hippocampus , bilateral parahippocampal gyrus , and fornix showed negative correlations with aging.
RESULTS : The FCR group reduced their energy intake for approximately @percent@ upon completion of the study.
RESULTS : The female replicas showed more and deeper wrinkles than the male replicas ( P < @number@ ) .
RESULTS : The FEV1-SES patterns were clear ( p < 0.001 ) and constant over time.
RESULTS : The final analyses included @number@ patients ( median age @number@ years ; females @number@ % ) .
RESULTS : The final cluster-defining variables were continuous measures of cognitive status and depressive symptoms , and dichotomous indicators of slow gait and exhaustion.
RESULTS : The final dataset included @number@ individuals , of whom @percent@ were African American.
RESULTS : The final recommendations are : ( @number@ ) Imperatively start antimicrobial treatment and remove the focus in Staphylococcus aureus bloodstream infection.
RESULTS : The final reduced model predicted @percent@ of the variance in LTPA , including an indirect effect of EI x OE through intrapersonal constraints.
RESULTS : The final sample size was @number@ individuals with traumatic SCI.
RESULTS : The final search provided @number@ titles with abstracts.
RESULTS : The final study population included @number@ colorectal patients and @number@ healthy controls.
RESULTS : The findings demonstrated that the intervention group had more knowledge ( t = @number@ P < @number@
RESULTS : The findings from the present study showed that @percent@ of older Malaysians are at risk for social isolation.
RESULTS : The findings indicated that approximately @percent@ of subjects had urinary incontinence.
RESULTS : The findings revealed barriers to effective LTC pain management at the resident / family , health care provider , and system levels.
RESULTS : The findings showed an historical decrease in cycling and running but not swimming times.
RESULTS : The findings showed that caring for a relative with dementia was perceived as a time-consuming , exhausting and long-term task.
RESULTS : The findings show that , contrary to some stereotypes , many older people are enthusiastic , competent and confident users of ICTs.
RESULTS : The findings were : age standard deviation @number@ with minimum as @number@ and maximum as @number@ years old.
RESULTS : The Finnish data demonstrate a marked increase in RBC consumption with increasing age among recipients , beginning at around @number@ years of age.
RESULTS : The first stage grouped the identified problems by level of similarity , comprising a body of @number@ issues for analysis.
RESULTS : The first two PCs captured @percent@ of the variability.
RESULTS : The fistulas in two cases were successfully coiled with complete obviation of symptoms and signs.
RESULTS : The five most dominant PCs accounted for @percent@ of underlying trait variance.
RESULTS : The following findings are reported.
RESULTS : The follow-up rate was @percent@ in @number@ stroke patients.
RESULTS : The formulations were stable in the visual and Ph evaluation.
RESULTS : The four alcohol use / nonuse groups did not differ in past-year MDE.
RESULTS : The four valves differed substantially in thickness , degree of anisotropy , and stiffness.
RESULTS : The fraction of t → m transformation increased with aging time.
RESULTS : The frame height inversely correlated with attractiveness in modern female portrait photographs.
RESULTS : The framework of communal coping provided the mechanism of aging better together intentionally.
RESULTS : The frequency of masked hypertension in our study group was @percent@.
RESULTS : The frequency of osteoporosis and osteopenia was found to be @percent@ and @percent@ , respectively , in the As exposure group.
RESULTS : The frequency of polymorphic C / T alleles of the calcitonin receptor gene in each group fit the Hardy-Weinberg equilibrium model.
RESULTS : The freshly isolated NK cell degranulation assay detected FHL3 patients with high sensitivity ( @percent@ ) but low specificity ( @percent@ ) .
RESULTS : The full analysis set comprised @number@ placebo- and @number@ micafungin-treated patients.
RESULTS : The functional measures worsened with age ( p < @number@ ) .
RESULTS : The gender difference in total performance time was stable until @number@ yr and then significantly increased.
RESULTS : The generalized estimating equations model revealed general improvement in outcomes among participants on the tai chi qigong program.
RESULTS : The glass ionomer group and Biodentine group presented an overall @percent@ and @percent@ of continuous margins , with no difference between them.
RESULTS : The glenoid and glenoid-coracoid interface were identified in infancy as a contiguous , cartilaginous mass.
RESULTS : The global point prevalence of neck pain was @percent@ ( @percent@ CI @number@ to @number@ ) .
RESULTS : The global prevalence of RA was @percent@ ( @percent@ CI @percent@ to @percent@ ) , with no discernible change from @number@ to @number@
RESULTS : The greatest risk for shortage of qualified staff was found in the fluctuation of doctors and in the aging work force.
RESULTS : The great majority of subjects had used a mobile phone ( @percent@ ) but few currently owned one ( @percent@ ) .
RESULTS : The group mean IWT was not significantly different from the actual walking time measured during a training session prior to the fMRI study.
RESULTS : The group of infants less than @number@ year had similar value as control group.
RESULTS : The GRS is used in ~500 clinics around the world.
RESULTS : The GSIS demonstrated strong test-retest reliability and internal consistency.
RESULTS : The HapMap data in the Han Chinese population showed that the I337V was used as a representative for @number@ common functional polymorphisms.
RESULTS : The health care professional's emotions fluctuated between powerlessness and meaningfulness.
RESULTS : The healthy , at-risk , and CKD groups consisted of @number@ @number@ and @number@ people , respectively.
RESULTS : The hearing thresholds decreased slightly from @number@ to @number@ Hz.
RESULTS : The hearing was essentially unchanged during the span of the investigation-almost three decades.
RESULTS : The height of Telefolmin subjects , below the fifth percentile in @number@ remained below the fifth percentile in @number@
RESULTS : The heterogeneity of the older population is highlighted.
RESULTS : The high-contrast Snellen acuities clustered at 20 / 15 and 20 / 20.
RESULTS : The highest accuracy for discriminating age differences was @number@ and @number@ for males and females , respectively.
RESULTS : The highest levels of PINP were observed during the first year of life.
RESULTS : The highest plasma cFGF23 and iFGF23 concentrations were found in subjects with the lowest serum iron levels ( p < 0.001 ) .
RESULTS : The highest prevalence of anemia ( @percent@ ) was observed in Jharkhand in eastern India.
RESULTS : The highest scoring category by patients was softness ( median , @number@ percent ) .
RESULTS : The highest standardized effect sizes were found for midbrain , frontal lobes , and the third ventricle.
RESULTS : The high patient expectations before treatment ( ceiling effect ) were actually slightly exceeded.
RESULTS : The horizontal and vertical diameters of the fields of effect and the areas were significantly larger for onabotulinumtoxinA than those obtained for abobotulinumtoxinA.
RESULTS : The hypertensive patients exhibited worse executive and memory abilities than control subjects.
RESULTS : The hypothesis was well supported by the data.
RESULTS : The hypothetical campaign cost was $ 5 , 960 , 000 ( in @number@ US dollars ) .
RESULTS : The ICC method showed a staffing of @number@ nurses : a staff shortage of three nurse , if compared to the actual staff.
RESULTS : The illiterate participants had poorer performance than the educated participants.
RESULTS : The improvement rate at maximum frown by live assessment was not significantly different between the MT10109L and Botox groups.
RESULTS : The improvements in fastest @number@ m running times over time were not significant.
RESULTS : The incidence rate of disability was @number@ per @number@ person-years.
RESULTS : The incidence rates of hip fracture during 2004-2011 were @number@ and @number@ per @number@ person-years among women and men , respectively.
RESULTS : The incidences of femoral neck , intertrochanteric , and subtrochanteric fractures were @number@ @number@ and @number@ per @number@ persons , respectively.
RESULTS : The incision healing of both groups by first intention was achieved.
RESULTS : The increasing number of nonablative systems all seem to be effective and safe when used in the recommended manner.
RESULTS : The informant described her experiences as a salon employee including her interactions with salon patrons.
RESULTS : The inhibition of proliferation was dampened in PBMCs from elderly donors , especially after incubation with rapamycin.
RESULTS : The initial model accurately predicted age in healthy individuals ( r = @number@ ) .
RESULTS : The injury rate was 22 / 1000 worker-years.
RESULTS : The intention to treat ( ITT ) analysis showed significant positive effects of the intervention on mental health.
RESULTS : The interaction between education level and WML volume reached significance ( p = @number@ ) .
RESULTS : The interaction between erythrocyte EPA , but not DHA , and increased physical activity was associated with increased odds of a non-MCI classification.
RESULTS : The interim results @number@ months after injection are reported.
RESULTS : The internal consistency of the NPI-NH reported a value ( α = 0.62 ) according to the literature.
RESULTS : The internal consistency reliability was good ( Cronbach's α = 0.71 ) .
RESULTS : The interocular correlations for several measures of RT and RT layers were high ( P < @number@ ) .
RESULTS : The interrater reliabilities for each measured point were excellent ( overall intraclass correlation coefficients = 0.94 ) .
RESULTS : The inter-rater reliability of the photonumeric grades was good to excellent ( intraclass correlation coefficients @number@.65-0.93 ) .
RESULTS : The intervention groups were similar at baseline with respect to body weight , body composition , lipids and blood pressure.
RESULTS : The intervention led to upregulation of miR-29a-3p and miR-29a-5p and downregulation of miR-20b-5p.
RESULTS : The intervention was cost neutral over the 2-year study period.
RESULTS : Their mean age was @number@ ± @number@ years and @number@ ( @percent@ ) patients were women.
RESULTS : The IR of AMI among subjects without PD was @number@.19% / year.
RESULTS : The irradiation of epidermal cells with sublethal UVB doses increased IL-6 expression and ROS generation.
RESULTS : The Italian translation was sound , with acceptability in the Italian-speaking sample and acceptable internal consistency scores for full-scale and subscales.
RESULTS : The Klotho recombinant protein induced transient phosphorylation of mitogen-activated kinases within a few minutes.
RESULTS : The knowledgebase was populated with over @number@ instances generated by a text-mining pipeline.
RESULTS : The laryngeal mask airway was successfully placed on the first attempt in all @number@ children.
RESULTS : The left thalamus had significantly higher overall cortical connectivity than the right thalamus ( P < @number@ ) .
RESULTS : The level of burden of caregivers in the intervention group reduced significantly compared with caregivers in the control group.
RESULTS : The level of superoxide anion in the RGC layer was significantly higher in 24-week-old SOD1-deficient mice than in wild-type mice.
RESULTS : The levels of adiponectin between in plasma and in CSF showed a positive correlation.
RESULTS : The levels of plasma GDF11 in the COPD group were decreased compared with the control groups in the two independent cohorts.
RESULTS : The Lipo-Facelift demonstrated very satisfying results.
RESULTS : The literature search yielded @number@ references , of which @number@ met the screening criteria.
RESULTS : The loads to fracture ( LTF ) values in the CN group were higher than those in the CW and experimental groups.
RESULTS : The low educated group had a lower number of correct responses than the high educated group on all blocks of the test.
RESULTS : The lowest average variance from chronological age was shown by the Greulich and Pyle method , followed by Demirjian.
RESULTS : The LSCS group was older and exhibited a longer symptom duration , wider segmental motion , and thicker LF than the control group.
RESULTS : The macroscopic findings showed significantly greater swelling in oligomycin-injected knees than in control knees.
RESULTS : The main effect of age is a reduced superexcitability.
RESULTS : The main outcome measurements were differences in orbital soft tissue densities.
RESULTS : The main results showed higher mean values on the HADS-D for cat owners than for both dog and non-pet owners.
RESULTS : The main symptom of cataract is loss of visual acuity , which usually progresses slowly.
RESULTS : The majority of cases ( 80-90% ) needed only a single session for creation of permanent improvement in facial volumes and contours.
RESULTS : The majority of diagnoses were depression ( @percent@ ) , dementia ( @percent@ ) , and schizophrenia ( @percent@ ) .
RESULTS : The majority of older veterans with newly diagnosed PTSD received at least one follow-up mental health visit.
RESULTS : The majority of participants relied on SMBG to evaluate their self-management efforts.
RESULTS : The majority of patients ( n = 115 , @percent@ ) reported two or more comorbidities.
RESULTS : The majority of patients were Latino Spanish speaking women on public insurance.
RESULTS : The majority of persons with stroke were aged @number@ and older , white , female , and married.
RESULTS : The majority of posts were part of online social games , including cognitive , associative , and creative games.
RESULTS : the majority of respondents ( @percent@ ) did not agree with age-based stoppage policies.
RESULTS : The majority of RGFDs of young women were higher than those of the older ones.
RESULTS : The majority of the AD patients were in the mild stage of the disease.
RESULTS : The majority of the sample ( @number@ % ) wanted disclosure for themselves.
RESULTS : The majority of the samples in the anti-elastase assay and nine in the anti-collagenase assay showed more than @percent@ inhibition.
RESULTS : The majority of traits had moderate to excellent agreement among observers ( ≥0.6 ) .
RESULTS : The majority ( @percent@ ) of the people tested passed both tests.
RESULTS : The majority ( @percent@ ) reported experiencing one or more traumatic or stressful life experiences during their life span.
RESULTS : The malar fat pad becomes atrophic and descends with aging.
RESULTS : The Male OPAQ™ can discriminate between men with and without fracture , and men who have more fractures have poorer scores.
RESULTS : The Mankin score indicated that lesion cartilage was more degraded compared with remote cartilage.
RESULTS : The manual layer segmentation showed clear boundaries between the GCL and the GCC.
RESULTS : The MARD value against reference glucose values > 4.2 mmol / L was @percent@ ( @percent@ CI @number@ @number@ ) .
RESULTS : Thematic content analysis was undertaken.
RESULTS : The MBTR significantly correlated to all standard measures of physical performance.
RESULTS : The mean age at baseline was @number@ ( sd @number@ ) years.
RESULTS : The mean age at dementia onset among those receiving antidepressants before onset was @number@ years versus @number@ years among others.
RESULTS : The mean age at the onset was @number@ ± @number@ years.
RESULTS : The mean age at the time of cochlear implantation was @number@ years old.
RESULTS : The mean age of all @number@ patients was @number@ years.
RESULTS : The mean age of FCs was @number@ ( ±10.6 ) years , whereas that of geriatric patients was @number@ ( ±6.4 ) years.
RESULTS : The mean age of @number@ subjects was @number@.2±7.3 years.
RESULTS : The mean age of participants was @number@ years.
RESULTS : The mean age of participants was @number@ years and @percent@ were women.
RESULTS : The mean age of participants was @number@ years , with @percent@ being female.
RESULTS : The mean age of sample was @number@.1±7.3 and @percent@ were illiterate.
Results : The mean age of study participants was @number@ years ( SD ± @number@ ) and @percent@ were female.
RESULTS : The mean age of study subjects was @number@.3±8.4 years and @percent@ were females.
RESULTS : The mean age of subjects was @number@.6±4.9 years , and @percent@ ( n = 66 ) were women.
RESULTS : The mean age of subjects was @number@ years.
RESULTS : The mean age of the enrolled patients was @number@ years , and @percent@ were males.
RESULTS : The mean age of the group was @number@ ± @number@ years , @number@ % of them were women.
RESULTS : The mean age of the males was @number@ + / - @number@ years.
RESULTS : The mean age of the @number@ included subjects was @number@.8±15.3 years , and @percent@ was male.
RESULTS : The mean age of the @number@ patients was @number@ years.
RESULTS : The mean age of the @number@ study subjects was @number@ years , and @percent@ of subjects had radiographically detected knee OA.
RESULTS : The mean age of the participants was @number@.1±6.9 years.
RESULTS : The mean age of the participants was @number@.5±4.4 years ( range : 18-35 years ) .
RESULTS : The mean age of the participants was @number@ ± @number@ years , with a mean follow-up period of @number@ ± @number@ weeks.
RESULTS : The mean age of the participants was @number@ ( range , 65-91 ) years old.
RESULTS : The mean age of the patients was 70±3.6 years , and @percent@ were men.
RESULTS : The mean age of the patients was @number@ ± @number@ years.
RESULTS : The mean age of the patients was @number@ years , and @number@ patients ( @percent@ ) were women.
RESULTS : The mean age of the patients was @number@ years ( range 65-94 ) .
RESULTS : The mean age of the patients was @number@ years ( SD = 9.2 ) , @percent@ of them were female.
RESULTS : The mean age of the population was @number@.2±10.1 years , and the mean deviation with HFA 24-2 was @number@.26±2.6 dB.
RESULTS : The mean age of the population was @number@ ( standard deviation @number@ ) .
RESULTS : The mean age of the sample population ( women @percent@ ) was @number@ ( SD = 8.3 ) years old.
RESULTS : The mean age of the sample was @number@
RESULTS : The mean age of the sample was @number@ years , @percent@ were women , and @percent@ were married.
RESULTS : The mean age of the study participants is @number@ ± @number@ years.
RESULTS : The mean age of the study population was @number@.73±5.48years.
RESULTS : The mean age of the study population was @number@.9±11.1 years and @percent@ were males.
RESULTS : The mean age of the study sample was @number@ ( range 65-102 ) ; @percent@ were female , and @percent@ were white.
RESULTS : The mean age of the subjects was 45±9 years and @number@ ( @percent@ ) were male.
RESULTS : The mean age was @number@.1±8.0 years and @percent@ were men.
RESULTS : The mean age was @number@.2±5.9 years.
RESULTS : The mean age was @number@ ± @number@ ( 26-75 ) years.
RESULTS : The mean age was @number@ ± @number@ months.
RESULTS : The mean age was @number@ ± @number@ years.
RESULTS : The mean age was @number@ ± @number@ years and @number@ ( @number@ % ) were female.
RESULTS : The mean age was @number@ ± @number@ years and @number@ ± @number@ years in children and in adults , respectively.
Results The mean age was @number@ ± @number@ years and @number@ ( @percent@ ) were ≥80 at enrolment.
RESULTS : The mean age was @number@ @percent@ were female ; @percent@ were elective admissions ; @percent@ were admitted to a medical specialty.
RESULTS : The mean age was @number@ ( SD @number@ ) years , with @percent@ female and @percent@ white.
RESULTS : The mean age was @number@ ± @time@ @number@ ± @time@ in patient group and in control group respectively.
RESULTS : The mean age was @number@ years ( 62-108 ) with a female predominance ( @number@ % ) .
RESULTS : The mean age was @number@ years , and BMI was @number@
RESULTS : The mean age was @number@ years , and @percent@ of the participants were men.
RESULTS : The mean age was @number@ years , @percent@ were female , and @percent@ were African-American.
RESULTS : The mean age was @number@ years ( standard deviation : @number@ ) .
RESULTS : The mean and SD for telomere length was @number@ ± @number@ T / S in the whole cohort.
RESULTS : The mean ANL was lower than previously reported.
RESULTS : the mean ASD score of @number@ indicated a mildly positive attitude towards the target population.
RESULTS : The mean BMI increased in both genders by age.
RESULTS : The mean BMI values observed ranged from @number@ kg / m² to @number@ kg / m².
RESULTS : The mean BMI was @number@.08±4.48 kg / m² and the mean MMSE @number@.68±5.38.
RESULTS : The mean bone mineral density of the coracoid process significantly decreased with age ( p < @number@ ) .
RESULTS : The mean CBF over whole gray matter was @number@ with intraclass correlation coefficient ( ICC ) of @number@
RESULTS : The mean CDVA was significantly better in the 30s and 50s than in the 60s and 70s ( P < .033 ) .
RESULTS : The mean choroidal thickness was @number@ ± @number@ µm.
RESULTS : The mean coherence value for the alpha band at O1O2 was @number@ ( SD @number@ ) .
RESULTS : The mean corneal densitometry over the total area was @time@ ± @number@ GSU.
RESULTS : The mean correlation coefficient ( rho ) was @number@ for Whites and @number@ for Blacks.
RESULTS : The mean Ct values were strictly identical ( @number@ ± @number@ ) and the @number@ PCR curves were coincident.
RESULTS : The mean dental practice experience was @number@ ± @number@ years with average @number@ ± @number@ working hours per week.
RESULTS : The mean DHEA-S levels were @percent@ lower in the subjects who reported stress at work compared to the non-stressed group.
RESULTS : The mean DMFT values for the sample , 11-14 , 14-17 and 17-20 year-olds were @number@ @number@ @number@ and @number@ respectively.
RESULTS : The mean duration from the last treatment was @number@ months.
RESULTS : The mean endurance time of all the participants was @number@ ± @number@ seconds.
RESULTS : The mean EQ-5D utility of children with all-causes diarrhea was @number@
RESULTS : The mean FI-Lab score was @number@.34±15 , with an upper limit of @number@
RESULTS : The mean follow-up period was @number@ years.
RESULTS : The mean follow-up was @number@ months.
RESULTS : The mean follow-up was @number@ ± @number@ years ( range 1-18 ) .
RESULTS : The mean GCS and mR scores were moderately severe and comparable between both groups.
RESULTS : The mean GDS at @number@ months was significantly lowered only for the n-3 group.
RESULTS : The mean global RNFL thickness was @number@ ± @number@ µm.
RESULTS : The mean GWR curves characterize the normal brain by only six , neuroanatomy-related numbers.
RESULTS : The mean hair density , hair thickness , and the white hair percentages were not significantly different between genders at any scalp site.
RESULTS : The mean HEI-2010 in childhood cancer survivors was @number@ about @number@ percent of the maximum score.
RESULTS : The mean HGS demonstrate a decreasing trend with increased age across all ethnic groups and sexes.
RESULTS : The mean improvement scores @number@ months after treatment with the 1550- and 1565-nm Er : glass lasers were @number@.25±0.62 and @number@.28±0.59 respectively.
RESULTS : The mean inner retinal layer thickness for the entire population was @number@ μm.
RESULTS : The mean interval between the two surveys was @number@ + / - @number@ years.
RESULTS : The mean kappa for intra-rater agreement during grading with CVM was @number@ ( fair agreement ) .
RESULTS : The mean keratometry reading was @number@ diopter ( D ) [ @percent@ confidence interval ( CI ) : @number@.22-44.57 ] .
RESULTS : The mean maximal walking speed was @number@ m / s ( range @number@.3-2.9 ) .
Results : The mean mHAI score was @number@ @percent@ had a score of 0-2.
RESULTS : The mean MSCD was @number@ mm ( @date@ @number@ ) across the whole cohort.
RESULTS : The mean myocardial TG content was @number@.85±0.40%.
RESULTS : The mean operation time was @number@ minutes , the mean blood loss was @number@ ml and all the incisions were healed primarily.
RESULTS : The mean overall years saved following aesthetic facial surgery was @number@ years ( range , @number@ to @number@ years ) .
RESULTS : The mean permeability K2 of the extracted CP was @number@.033 + / -0.18 s ( @number@ ) .
RESULTS : The mean postoperative straylight value derived from @number@ studies ( @number@ eyes ) was @number@ log units ± @number@ ( SD ) .
RESULTS : The mean protein requirement ( @percent@ CI ) was @number@ ( @number@ @number@ ) g · kg⁻¹ · d⁻¹.
RESULTS : The mean score on the purpose in life measure at baseline was @number@ ( standard deviation = @number@ range : 2-5 ) .
RESULTS : The mean±SD , 3rd , 10th , 25th , 50th , 75th , 90th and 97th centile values of lipid parameters are presented.
RESULTS : The mean ( ±SD ) age at baseline was @number@ ± @number@ y.
RESULTS : The mean ( SD ) age of the @number@ patients was @number@ ( @number@ ) years.
RESULTS : The mean ± SD age of women at baseline was @number@ ± @number@
RESULTS : The mean ( SD ) follow-up time was @number@ ( @number@ ) years.
RESULTS : The mean ± SD HEI-2010 in childhood cancer survivors was @number@ ± @number@ of a maximum score of @number@
RESULTS : The mean ± SD number of drugs with anticholinergic properties taken by the subjects was @number@ ± @number@
RESULTS : The mean±SD patient age was 78±8 years , and @percent@ were nonwhite.
RESULTS : The mean ± SD resident age was @number@ ± @number@ years.
RESULTS : The mean ( standard deviation ) age of the subjects was @number@ ( @number@ ) years and @percent@ of them were male.
RESULTS : The mean ( standard deviation ) age was @number@ ( @number@ ) years , and @percent@ of participants were female.
RESULTS : The mean ( standard deviation ) GFR decline rate was @number@ ( @number@ ) mL / min / year.
RESULTS : The mean tHcy was within the normal range in this population.
RESULTS : The mean total free recall DDT score was @percent@ ( range = @number@ to @percent@ ) .
RESULTS : The mean total TFI score was @number@.7±3.1.
RESULTS : The mean unaccommodated LT for all participants was @number@ ± @number@ mm.
RESULTS : The mean value for any fracture and hip fracture probabilities for FRAX were @number@ ± @percent@ and @number@ ± @percent@ , respectively.
RESULTS : The mean value of LV ejection fraction did not change with age.
RESULTS : The mean values of early and delayed SUVmax of Schmorl's nodes without MRI enhancement were @number@ ± @number@ and @number@ ± @number@
RESULTS : The mean values of the right and left breast volumes were calculated as @number@.0±342.5 mL and @number@.3±347.2 mL , respectively.
RESULTS : The mean world standardized multimorbidity prevalence for LMICs was @number@ % ( @number@ % CI , @number@ % - @number@ % ) .
RESULTS : The median age at stroke onset was @number@ years in both groups.
RESULTS : The median age of both groups was similar ( @number@ vs. @number@ years , p = @number@ ) .
RESULTS : The median age of the Ashkenazi subjects was @number@ ( interquartile range ( IQR ) 95-104 ) .
RESULTS : The median age of the participants was @number@ years ( range , 15-86 ) .
RESULTS : The median age of the patients was @number@ ( 30-95 ) years.
RESULTS : The median age was @number@ for group @number@ ( range 70-79 ) and @number@ for group @number@ ( range 80-92 ) .
RESULTS : The median age was @number@ years and median FU @number@ years ( maximum @number@ years ) .
RESULTS : The median age was @number@ years , and @number@ ( @percent@ ) were women.
RESULTS : The median age was @number@ years ( interquartile range : 71-83 ) .
RESULTS : The median age was @number@ years ; @number@ patients were men , and @number@ were women.
RESULTS : The median age was @number@ years old.
RESULTS : The median duration of follow-up was @number@ years ( interquartile range , @number@.6-5.8 years ) .
RESULTS : The median duration of moderate-to-severe hot flushes was @number@ years and was strongly associated with menopausal stage at onset.
RESULTS : The median follow-up duration after surgery was @number@ months ( range 6-159 months ) for all patients.
RESULTS : The median follow-up time for the cohort ( n = @number@ ) was @number@ years ( interquartile range @date@ @number@ years ) .
RESULTS : The median follow-up time was @number@ years [ interquartile range ( IQR ) @date@ years ] .
RESULTS : The median follow-up was @number@ months.
RESULTS : The median ICC was @number@ across nonsex chromosomes and @number@ on the X chromosome.
RESULTS : the median inclusion rate was @percent@ ( @number@.9-84.5% ) .
RESULTS : The median [ interquartile range ( IQR ) ] annual moving-average BC concentration was @number@ ( @number@ @date@ ) microg / m3.
RESULTS : The median ( IQR ) patient age in this cohort was @number@ years ( 58-68 ) .
RESULTS : The median KT vintage was @number@ months.
RESULTS : The median LOS was @number@ days.
RESULTS : The median of the age of participants was @number@ years.
RESULTS : The median of the overall score of CECS equaled @number@ points , which is considered average in terms of negative emotions acceptance.
RESULTS : The median ( Q1 , Q3 ) of myocardial T2 in the normals was @number@ ms ( @number@ @number@ ) .
RESULTS : The median time from coarctation repair to reoperation was @number@ years.
RESULTS : The median XI score was @number@ ( min-max = 11-33 ) .
RESULTS : The men feel healthy , but prostate cancer affects their daily lives.
RESULTS : The MES included both patients aged 25-64 ( n = @number@ ) and ≥65 ( n = @number@ ) years.
RESULTS : The meta-analysis provided @number@ consensus integromics modules across mouse datasets and revealed microRNA relations with substantial collective action during aging.
RESULTS : The microarray data revealed significant down regulation in OXPHOS genes in AD , particularly those encoded in the nucleus.
RESULTS : The minimum distance from ET to ICA was @number@ mm ( average @number@ mm ) .
RESULTS : The mission of the medical units is devoted mainly towards elderly people.
RESULTS : the MMDs were trialled by @number@ patients ; the majority rated text readability well but rated MMDs poorly according to the other criteria.
RESULTS : The MMSE-MoCA conversion table is consistent with previously published tables and has an intra-class correlation of @number@ with the ADNI sample.
RESULTS : The MMSE was administered to @number@ residents living in @number@ LTCF.
RESULTS : The model developed in the @percent@ sample of HALS was strong and reproducible in the other data sets.
RESULTS : The model for osteoblastic differentiation of VSMCs was established in vitro by treating mouse VSMCs with @number@ mM β-GP for 3-15 days.
RESULTS : The model identifies statistically significant differences in the effect that diverse types of perceived discrimination can generate on the self-rated health of Europeans.
RESULTS : The model performance was examined in Monte-Carlo simulations.
RESULTS : The model ( RMSEA = @number@ CFI = @number@ ) showed the effects of all of the investigated determinants.
RESULTS : The model we report contained coefficients for two variables : sadness and tiredness , as well as a constant.
RESULTS : The morbidity rate was @percent@ ; two arterial punctures were reported with one self-limiting hematoma.
RESULTS : The mortality rate among the @number@ eligible beneficiaries with HF was @percent@.
RESULTS : The most common complications were pyocystis ( @date@ ) , bleeding ( @date@ ) , and pain-related symptoms ( @date@ ) .
RESULTS : The most common facilitator was the incorporation of specialized staff.
RESULTS : The most frequent cause of increased P100 latency was multiple sclerosis.
RESULTS : The most frequently fused spinous process was at S2 level.
RESULTS : The most frequent underlying cause of death in this cohort was cardiovascular ( @percent@ ) , followed by dementia ( @percent@ ) .
RESULTS : The most important effect of the study is quantification how different age groups mortality reduction impacts life expectancy of the newborn.
RESULTS : The most important pharmaceutical agents are beta secretase inhibitors , and active and passive immunizations.
RESULTS : The most prevalent symptoms were joint , muscle and back pain , cramps , abdominal pain and breast tenderness.
RESULTS : The most significant finding of the present research was that HFD induced the deposition of the βA peptide.
RESULTS : The mRNA and protein levels of OGG1 were significantly reduced in the lens cortex of ARC.
RESULTS : The multibiomarker risk score was associated significantly with risk for BE.
RESULTS : The MusEQ showed excellent internal consistency.
RESULTS : The n1 oVEMP latencies had a mean delay in the elderly of @number@.32ms with @percent@ CI of @number@.55-4.10ms.
RESULTS : The NAR-M indicated M = @percent@ adherence at Time @number@ ( SD = @percent@ ) .
RESULTS : The necessary weight loss for significant improvement of risk factors ranged from @number@ to @number@ kg.
RESULTS : The neural representation of simple ( tone ) and complex ( / da / ) stimuli declines with advancing age.
RESULTS : The newly developed Duke FI had content , construct , concurrent , and predictive validity.
RESULTS : The new Rapid Assessment Interface and Discharge service assessed @number@ patients compared to @number@ by the previous liaison team over the 4-month period.
RESULTS : The New Zealand sample scored @number@ points higher on average than the US sample on the @number@ point cognitive scale.
Results : The NHANES comprised @number@ respondents aged @number@ years and older who completed the DSST measuring cognitive performance.
RESULTS : The nine included studies differed in terms of qualitative method used , comprehensiveness of reporting , and geographical origin.
Results : The non-traumatic cannula technique resulted in product being confined to the deep anatomic layers.
RESULTS : The normal central foveal thickness in healthy Indian eyes measured using Spectralis OCT was @number@ ± @time@ ΅m.
RESULTS : The normalized volumes ( by intracranial volume , ICV ) of the hippocampus in males were smaller than those in females.
RESULTS : The normal upper limit of ACR was @number@ mg / g for male children and @number@ mg / g for female children.
RESULTS : The novel probe yielded rapid reproducible results and was easy to manage.
RESULTS : The NPI has reasonably good content validity and internal consistency , and good test-retest and interrater reliability.
RESULTS : The NRS scores of knee pain decreased significantly with increasing fruit and vegetable intake quartiles.
RESULTS : The NSHAP network change module was successful in providing reliable information about specific changes that occurred within respondents ' confidant networks.
RESULTS : The nulliparous women had higher PFM electromyographic activity than the other groups.
RESULTS : The @number@ ESs were far more likely never to have smoked.
RESULTS : The @number@ ET cases and @number@ controls were similar with respect to age , gender and other demographic variables.
RESULTS : The @number@ groups demonstrated no significant differences in frequencies of overall or septic complications , reoperation , or in-hospital death.
RESULTS : The @number@ included studies varied considerably in terms of size , scope and focus.
RESULTS : The @number@ LAR metrics are remarkably similar between healthy young humans and mice.
RESULTS : The @number@ matched patients had a mean age of @number@ ± @number@ years , @percent@ were women , and @percent@ were African American.
RESULTS : The @number@ % ( n = 375 ) of total population used at least one drug with anticholinergic properties.
RESULTS : The number of deaths remained at approximately @number@ in 1996-2008.
RESULTS : The number of incident cases of GCA will increase secondary to an aging population.
RESULTS : The number of MCs increased from @number@ in @number@ to @number@ in @number@ and to @number@ in @number@
RESULTS : The number of MSK deaths increased by @percent@ between @number@ and @number@ mainly due to population aging.
RESULTS : The number of PCs retained for analysis was chosen using a @percent@ trace criterion.
RESULTS. The number of subjects categorised by HPI was @number@ @number@ and @number@ respectively.
RESULTS : The number of subjects with frailty was @number@ ( @percent@ ) .
RESULTS : The number of subjects with frailty was @number@ ( @percent@ ) .
RESULTS : The @number@ OSA patients were over-weight but not obese and had higher IR than the non-OSA patients.
RESULTS : The @number@ participants , ages 66-88 yr , attended an average of @number@ of @number@ sessions.
Results : The @number@ participants included @number@ women and @number@ men with a mean ( SD ) age of @number@ ( @number@ ) years.
RESULTS : The @number@ participants in @number@ trials were significantly younger than the US KTR population ( P < 0.05 ) .
RESULTS : The @number@ participants in the prospective validation study had a mean age of @number@ years , and @percent@ had dementia.
RESULTS : The @number@ patients had a mean age of @number@ ± @number@ years , and @number@ % were males.
RESULTS : The @number@ prevalence was @number@ per @number@ persons and the @number@ prevalence was @number@
RESULTS : The numbers of cases of all age-related eye diseases are expected to rise in the coming years.
RESULTS : The numbers of patients in groups A , B , C , and D were @number@ @number@ @number@ and @number@ respectively.
RESULTS : The numbers of Sertoli cells in the aged groups were significantly lower than that in the controls ( p < @number@ ) .
RESULTS : the @number@ subjects had a mean age of @number@ years , @percent@ were women , and mean unadjusted hand-grip strength was @number@ kg.
RESULTS : The @number@ subjects had a median follow-up duration of @number@ years.
RESULTS : The nutritional status of most patients ( @percent@ ) was appropriate but @percent@ were at risk of malnourishment and @percent@ were malnourished.
RESULTS : The odds of abstinence increased and the odds of heavy drinking decreased during the study period.
RESULTS : The OGTT results were used for the diagnosis of diabetes mellitus using World Health Organization criteria.
RESULTS : The older adults were the more resilient group especially with respect to emotional regulation ability and problem solving.
RESULTS : The older adults with aMCI performed significantly poorer on all three tasks in the everyday task battery.
RESULTS : The O-O group reported higher levels of SPSA than the Y-O group.
RESULTS : The operation of each patient with a mean follow-up period of @number@ months was combined for a total of @number@ rejuvenation operations.
RESULTS : The orbital aperture width and orbital aperture area increased significantly with age for both sexes.
RESULTS : The original report included the outcomes for @number@ patients ( @number@ RTSAs ) who had been followed for a mean of @number@ months.
RESULTS : The osseous patellofemoral joint morphology measurements were all within a normal range.
RESULTS : The overall ADR in the sample was @percent@.
RESULTS : The overall average MPOD for the population obtained with the centre-only approach for @number@ individuals was @number@ ± @number@
RESULTS : The overall consensus for all items and raters was @percent@ ( corrected ) .
RESULTS : The overall correlation coefficient between PSL and maximal velocity of PSU was highly significant but unexpectedly low ( r = 0.269 ) .
RESULTS : The overall frequency of colposcopy referrals was @percent@ in both screening arms.
RESULTS : The overall incidence of repeat vertebral augmentation was @percent@ during the follow-up until @number@
RESULTS : The overall Knowledge and Attitude scores were @percent@ ( @number@ @date@ ) and @percent@ ( @number@.9 / 52 ) , respectively.
RESULTS : The overall observed rate of new institutionalizations was @percent@ ( N = @number@ ) .
RESULTS : The overall prevalence estimates of MetS among longevity group were @percent@ based on NCEP ATPIII criteria.
RESULTS : The overall prevalence for hypertension was @percent@.
Results : The overall prevalence of anosmia was @percent@ among blacks and @percent@ among whites.
Results The overall prevalence of disability ( score : 1-12 ) was @percent@ ( women : @percent@ ; men : @percent@ ) .
RESULTS : The overall prevalence of FI was @percent@ , being @percent@ and @percent@ for males and females respectively.
RESULTS : The overall prevalence of H. pylori infection was @percent@ in women and @percent@ in men.
RESULTS : The overall prevalence of IgA deficiency was found to be very low with only @percent@ of individuals affected.
RESULTS : The overall prevalence of LT was @percent@.
RESULTS : The overall QOL was good in two-thirds of the elderly patients.
RESULTS : The overall response rate was @percent@.
RESULTS : The overall standardized effect of age on muscle fatigue was positive ( @number@ ) .
RESULTS : The overall structure of vessel walls was shown by HE and EVG staining , respectively.
RESULTS : The overall success rate in the patients was @percent@.
Results : The overall success rate of device implantation was @percent@ ( @number@ surgical conversions immediately ) .
RESULTS : The overall SVR CONCLUSIONS : There was a minimal impact of hepatitis B core antibody seropositivity on HCV efficacy and safety.
RESULTS : The overall trophic factor secretion profile of cultured fetal RPE cells remained stable over multiple passages and extended culture duration.
RESULTS : the overall weighted prevalence of frailty was @percent@.
RESULTS : The overwhelming majority reported finding the Carer Support Needs Assessment Tool assessment process straightforward and easy.
RESULTS : The PACSLAC-II demonstrated satisfactory reliability , excellent validity , and ability to differentiate between pain and nonpain states.
RESULTS : The Parkinson's Progression Marker Initiative represents a study population with low genetic heterogeneity.
RESULTS : The participants are mostly male , with an average age of @number@ years , married , residing in rural areas.
RESULTS : The participants ' mean ± SD age was @number@ ± @number@ years , and @percent@ were women.
RESULTS : The participants reported a moderate level of quality of life , with the exception in the domain of social relationships.
RESULTS : The participants were older ( mean @number@.5±9.5 years ) and predominantly male ( @percent@ ) .
RESULTS : The patient and investigator clinical assessments showed minimal improvement in skin laxity.
RESULTS : The patient early terminated treatment due to dengue fever but eventually achieved SVR12.
RESULTS : The patient group had higher serum free T4 levels and suppressed TSH levels compared with the control group.
RESULTS : The patient presented with a thalamic infarct associated with a thrombus in the vein of Galen.
RESULTS : The patients and their caregivers participated in @number@ diaries and @number@ observation sessions.
RESULTS : The patients experienced both clinically and statistically significant pain reduction when a vibration stimulus was co-administered with the dermal filler injections.
RESULTS : The patients with PCOS had statistically significantly elevated AMH levels ( @time@ ±2.63 ng / ml ; p < 0.0001 ) .
RESULTS : The pattern of age-related differences in computer use was consistent with prior research with older adults.
RESULTS : The patterns of change in the means of %BF and BMI were different ( P < @number@ ) .
RESULTS : The patterns of family caregivers ' mental health best fit a three-group trajectory model ( poor , moderate , and good ) .
RESULTS : The PDQ-8 was found to have good validity and reliability.
RESULTS : The peak age of NAION onset was between @number@ and @number@ years.
RESULTS : The peak growth age ( PGA ) was @number@ years for boys and @number@ years for girls.
RESULTS : The Pearson's correlation coefficients between GIP and the four memory tests were between @number@ and @number@ ( p < @number@ ) .
RESULTS : The percentage of individuals undertaking ≥ @number@ h of PA per week decreased from @percent@ to @percent@ between adolescence and midlife.
RESULT ( S ) : The percentage of morphologically normal spermatozoa showed a decrease from roughly 30%-80% in @number@ to 0%-10% since @number@
RESULTS : The percentage of participants who had hypertension increased as people aged , which was mainly caused by the increase of systolic blood pressure.
RESULTS : The pertinent literature remains scarce and of mixed quality.
RESULTS : The PE which included biochemistry variables performed only marginally better than the anthropometric PE.
RESULTS : The phagocytosis of C. albicans is developed by DCs in TLR2- and TLR4-dependent way.
RESULTS : The pharmacokinetic and pharmacodynamic time profiles were left-shifted for faster aspart versus IAsp.
RESULTS : The pharmacokinetics of oxycodone showed age dependency.
RESULTS : The pharyngeal-esophageal time was shorter in group I subjects than in group II and III subjects ( P < 0.05 ) .
RESULTS : The phenotype of SA was present in @percent@ of participants.
RESULTS : The PLA-retinyl retinoate microsphere was more effective for the permeation of retinyl retinoate than retinyl retinoate in itself.
RESULTS : The plasma levels of KL-6 increased with age both in non-smokers and smokers.
RESULTS : The platelet response to adenosine diphosphate @number@ µΜ and @number@ µΜ at T0 were @number@ ± @number@ and @number@ ± @percent@ , respectively.
RESULTS : The point prevalence of DSM-IV depressive disorders in patients with COPD and controls were @percent@ and @percent@ , respectively.
RESULTS : The Population of Ireland is projected to grow by @percent@ between @number@ and @number@ and by @percent@ for the over 70s.
RESULTS : The population was primarily male , middle-aged , and ethnically diverse.
RESULTS : The post-intervention fall incidence rate for mentally ill residents was @percent@ , which was significantly better than our target.
RESULTS : The post-mortem level of Alzheimer's disease neuropathology was linearly related to rate of decline in word knowledge.
RESULT ( S ) : The power model was an excellent fit to the observed data.
RESULTS : The PrCCI varied from @number@ to @number@ points ( median = 2 points , RI25-75 = 1-3 ) .
RESULTS : The premanifest HD subjects scored significantly lower on the working memory score.
RESULTS : The premenopausal women were significantly stronger and performed better in chair stands than perimenopausal and postmenopausal women.
RESULTS : The presence of cofilin rods / aggregates correlated with the extent of tau pathology independent of patient age.
RESULTS : The present study developed a reliable and valid home nursing quality scale from the perspective of users of home nursing services.
RESULTS : The prevalence of 25OHD < 20 ng / mL was of @percent@ ( CI @percent@ @number@.6-64.6 ) .
RESULTS : The prevalence of AF was not different between the MS and non-MS group.
RESULTS : The prevalence of anemia was @percent@ and was found to be higher in oldest adults.
RESULTS : The prevalence of anemia was @percent@ at baseline , @percent@ at 2-year follow-up , and @percent@ at 5-year follow-up.
RESULTS : The prevalence of aortic valve calcium across the @number@ CHARGE cohorts was @percent@ ( n = @number@ ) .
RESULTS : The prevalence of apathy was @percent@ in the LonGenity cohort and @percent@ in the CCMA cohort.
RESULTS : The prevalence of attempted suicide in the elderly was @percent@.
RESULTS : The prevalence of back pain ranged from @percent@ ( China ) to @percent@ ( Poland ) .
RESULTS : The prevalence of chronic diseases rose sharply with age.
RESULTS : The prevalence of cognitive impairment was @percent@.
RESULTS : The prevalence of current depression in the sample was @percent@ ( n = @number@ ) .
RESULTS : The prevalence of depressive episode among those with and without tuberculosis was @percent@ and @percent@ , respectively ( P < @number@ ) .
RESULTS : The prevalence of depressive symptoms was @percent@.
RESULTS : The prevalence of depressive symptoms was @percent@ , with the @percent@ confidence interval @number@ - @number@
RESULTS : The prevalence of doctor-diagnosed CMC1 OA in adults was estimated at @percent@ ( @percent@ in women and @percent@ in men ) .
RESULTS : The prevalence of dry eye in the BOSS was @number@.5% : @percent@ of women and @percent@ of men.
RESULTS : The prevalence of early AMD was @percent@ , and @percent@ of participants were vitamin D deficient.
RESULTS : The prevalence of ED visits by older adults was @number@ %.
RESULTS : The prevalence of elder abuse showed large variations across sites.
RESULTS : The prevalence of falling in the preceding @number@ months was @percent@.
RESULTS : The prevalence of frailty was @percent@.
RESULTS : The prevalence of frailty was @percent@ ( SOF index ) , @percent@ ( CHS index ) , and @percent@ ( KFI ) .
RESULTS : The prevalence of geriatric syndromes increased with age.
RESULTS : The prevalence of GFR < 60 mL / min / 1.73m2 was @percent@.
RESULTS : The prevalence of glaucoma rises with age.
RESULTS : The prevalence of having depressive symptoms and being at risk of malnutrition / malnourishment in @number@ was @percent@ and @percent@.
RESULTS : The prevalence of hearing handicap was @percent@.
RESULTS : The prevalence of hearing loss increased over time in better and worse ear.
RESULTS : The prevalence of heavy / excessive drinking was @percent@ , daily drinking @percent@ , and binge drinking @percent@.
RESULTS : The prevalence of HI was @percent@ , and the mean ( SD ) WRCM score was @percent@ ( @percent@ ) .
RESULTS : The prevalence of hospital care use for non-disability retirees remained stable during the 6-year study window.
RESULTS : The prevalence of hyperuricemia and MCI was @percent@ and @percent@ respectively.
RESULTS : The prevalence of Hypogonadism among all study participants was @percent@.
RESULTS : The prevalence of individuals who fall was @percent@ in AD and @percent@ in non-AD ; whereas it was @percent@ in CHIs.
RESULTS : The prevalence of internal disc disruption , facet joint pain and sacroiliac joint pain was @percent@ , @percent@ , and @percent@ , respectively.
RESULTS : The prevalence of knee pain was found in @percent@ of the studied sample.
RESULTS : The prevalence of low muscle mass at the first wave of examinations was @percent@ in men and @percent@ in women.
RESULTS : The prevalence of malnutrition ( SGA B + C ) was @percent@.
RESULTS : The prevalence of malnutrition was @percent@ and @percent@ was at risk of malnutrition.
RESULTS : The prevalence of MCCs increased from @percent@ in @number@ to @percent@ in @number@
RESULTS : The prevalence of MCI in older people living in publicly managed congregate housing was @percent@.
RESULTS : The prevalence of MCI was @percent@ and the amnestic multiple domain was the most frequent subtype ( @percent@ ) .
RESULTS : The prevalence of MetS and MCI was 59·1% and 15·9% , respectively.
RESULTS : The prevalence of morbidity and multimorbidity was @number@ % and @number@ % , respectively , in the pooled sample of six countries.
RESULTS : The prevalence of MS was found to be inversely related with PAL.
RESULTS : The prevalence of MS was @percent@.
RESULTS : The prevalence of multimorbidity in this population was @percent@ ( @percent@ confidence interval [ CI ] , 65%-68% ) .
RESULTS : The prevalence of nocturia was @percent@ ( weighted @percent@ CI @date@ @number@ ) .
RESULTS : The prevalence of OH among older adults in Singapore was @percent@.
RESULTS : The prevalence of OH during HUT and AST was @percent@ and @percent@ , respectively.
RESULTS : The prevalence of orthostatic hypertension and hypotension was @percent@ and @percent@ in hypertensive patients.
RESULTS : The prevalence of participants who drink alcohol in the Chinese and Norwegian sample were @percent@ and @percent@ , respectively.
RESULTS : The prevalence of PCO by AFC was @percent@ and decreased with age.
RESULTS : The prevalence of PIM use was @percent@ ( 95%CI @number@.4-58.6 ) .
RESULTS : The prevalence of pinguecula was @percent@ ( @percent@ confidence interval ( CI ) : @number@.9-51.9 ) .
RESULTS : The prevalence of polypharmacy in this study was @percent@.
RESULTS : The prevalence of potential DDIs was @percent@ ( @number@ of @number@ ) .
RESULTS : The prevalence of pre- and postmenopausal women with SVH was @percent@ and @percent@ , respectively ( P > 0.05 ) .
RESULTS : The prevalence of psychosis in AD ( @percent@ ) was higher than in MCI ( @percent@ ; p < @number@ ) .
RESULTS : The prevalence of questionable dementia was @percent@ and definite dementia was @percent@.
RESULTS : The prevalence of sarcopenia was @percent@ ( 95%CI : @number@.8%-21.8% ) , similar in men and women.
RESULTS : The prevalence of sarcopenia was @percent@ and @percent@ using the EWGSOP and FNIH criteria , respectively.
RESULTS : The prevalence of sarcopenia was @percent@ in men and @percent@ in women.
RESULTS : The prevalence of sexual symptoms of male aging was @percent@ ( @percent@ CI : @number@.3%-69.1% ) .
RESULTS : The prevalence of skin diseases among hospitalized geriatric patients was @time@ %.
RESULTS : The prevalence of SNs was @percent@.
RESULTS : The prevalence of ( S ) was @time@ % in women and @time@ % in men.
RESULTS : The prevalence of tinnitus was @percent@.
RESULTS : The prevalence rate of at least one comorbid ICD in our sample was @percent@.
RESULTS : The prevalence rate of women at high risk of having osteoporosis was @percent@ ; @percent@ were considered at moderate risk.
RESULTS : The prevalence rates of chronic back pain and chronic arthritis / joints pain were higher in women than men.
RESULTS : The prevalence rates of stunting , underweight , and wasting did not exceed @percent@ based on the World Health Organization growth references.
RESULTS : The prevalences of sarcopenia and dysphagia were @percent@ and @percent@ , respectively.
RESULTS : The prevalence was @percent@ for frequent cough , @percent@ for chronic persistent cough , and @percent@ for nocturnal cough.
RESULTS : The prevalence was @percent@ for PAD , @percent@ for moderate stenosis , @percent@ for severe stenosis , and @percent@ for increased cIMT.
RESULTS : The prevalence was @percent@ for psychological distress and @percent@ for severe psychological distress among all participants.
RESULTS : The prevalent population in CVD includes adult and aging subjects ; four out of five are women.
RESULTS : The primary electronic literature search identified a total of @number@ records in the six different databases.
RESULTS : The primary end point was met.
RESULTS : The principal component accounted for @percent@ in male and @percent@ in female of the total variance in the battery of five variables.
RESULTS : The probability of hypogonadal symptoms increased at a serum TT level of @number@ ng / dL.
RESULTS : The process of care variables did not significantly differ between the two age groups.
RESULTS : The program for lower-limb muscle endurance significantly increased balance ( p < 0.05 ) in the evaluation tests after the training program.
RESULTS : The progression to clinical endpoints varied a great deal among the trials.
RESULTS : The project underwent multiple changes over its life span , including the addition of an option to mail patients educational materials about falls.
RESULTS : The proportion of caregivers with poor mental health was @percent@.
RESULTS : The proportion of elderly participants with normal function decreased with time throughout the study period.
RESULTS : The proportion of elderly patients increased from @percent@ of all ICU patients in @number@ to @percent@ in @number@
RESULTS : The proportion of hardcore smokers among smokers did not change significantly from @percent@ in @number@ to @percent@ in @number@
Results : The proportion of MyHCI + sto myofibers was significantly smaller in the orbital and global layer of ALS compared to control individuals.
RESULTS : The proportion of older PLWHA increased from @percent@ in @number@ to @time@ % in @number@
RESULTS : The proportion of participants with SI population was @percent@.
RESULTS : The proportion of patients with a simple fall as the etiology of their injury showed a statistically significant trend to increase with aging.
RESULTS : The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis.
RESULTS : The proportion of respondents using at least one VMFO was @percent@ in @number@ and @percent@ in @number@ ( p < 0.001 ) .
RESULTS : The proportion of survivors to age @number@ was markedly smaller among the Finnish men and women than Danish or Swedish subjects.
RESULTS : The proportions of grandparents providing childcare to grandchildren differ considerably between China ( @percent@ ) and South Korea ( @percent@ ) .
RESULTS : The proportions of patients with angiographic vasospasm , DINDs , and TCD abnormalities were @percent@ , @percent@ , and @percent@ , respectively.
RESULTS : The proposed method was applied to liver and lung cancer mortality data on Japanese men for illustration.
RESULTS : The proposed model substantially simplifies the chain of events potentially leading to organ rejection.
RESULTS : The proposed taxonomy divides uncertainty along three axes-source , issue , and locus-and further discriminates the uncertainties into five layers with multiple domains.
RESULTS : The prospective analysis indicated that @percent@ of the individuals eventually moved to an elder care institution.
RESULTS : The provision of telemedicine health services increased rural population QALE by @number@ quality-adjusted life years.
RESULTS : The psychometric properties of the CODE and KIDE scales are reported.
RESULTS : The PTD-EGF and FGF1 increased cell proliferation and collagen type @number@ alpha @number@ protein accumulation in skin tissue.
RESULTS : The quantity and quality of food items provided at the four daycare centers examined varied greatly.
RESULTS : The questionnaire was repeatable and able to discriminate between older women with and without vertebral fractures.
RESULTS : The radiographic dataset resulted in a correlation of radius length and width of r = 0.753 ( adj.
RESULTS : The range of rank-order DASH and Mediterranean diet scores was 1661-25 , 596 and 2407-26 , 947 , respectively.
RESULTS : The rate of baseline hypertension was @percent@ in this cohort and the mean nail selenium level is @number@.413±0.183μg / g.
RESULTS : The rate of care providers ' adherence to the communication plans was @percent@.
RESULTS : The rate of invasive pneumococcal disease per @number@ increased with increasing age.
RESULTS : The rate of malnutrition in the study population was @percent@ while the malnutrition risk was @percent@.
RESULTS : The rate of pre-eclampsia was @percent@.
RESULTS : The rates of postoperative complications ( @percent@ in group @number@ and @percent@ in group @number@ ) were not significantly different.
RESULTS : The RBM was visible by light microscopy at @number@ weeks gestation.
RESULTS : The readers will be aware of the results of the interaction with BoNTA.
RESULTS : There are intrinsic differences in skin and hair of darker-complexioned men , particularly in Hispanics , African Americans , Asians , and Afro-Caribbeans.
RESULTS : There are significant sex differences in the pattern of change in QUS parameters ( p < @number@ ) .
RESULTS : The recall rate at @number@ years was @percent@.
RESULTS : The records of @number@ patients were studied.
RESULTS : The reduction in nasolabial wrinkles was statistically significant at @number@ months after the first implant.
RESULTS : There exist both significant similarities and differences between adults and elderly with PTSD concerning cognitive and biological profile.
RESULTS : The reference group comprised @number@ adults ( 423F ; @number@ ± @number@ years ) .
RESULTS : The regions identified for each variant were generally what would be expected from prior studies of frontotemporal lobar degeneration ( FTLD ) .
RESULTS : The rehabilitation period averaged @number@ ± @number@ days.
RESULTS : There is conflicting evidence regarding the usefulness of creatine supplementation in older subjects.
RESULTS : There is heterogeneity in health services utilization across the late lifespan.
RESULTS : There is indeed some adverse selection in the URBMI and the NCMS.
RESULTS : There is not sufficient evidence to draw conclusions regarding the effectiveness of exercise for LSS.
RESULTS : there is wide variability in the choice of equipment and protocol for measuring grip strength.
RESULTS : The relationship between age and gait symmetry and regularity was statistically significant for both vertical and anteroposterior axes.
RESULTS : The relationship between age , findings on digital rectal examination , serum tPSA , abdominopelvic ultrasonography report , and histology are compared.
RESULTS : The relationship between control beliefs and memory performance was moderated by confidence.
RESULTS : The relationship between education and dietary habits was mediated by three variables excluding social support.
RESULTS : The relationship between log TSH and free T₄ was nonlinear.
RESULTS : The relationship was the strongest between cognitive ability and nutritional status among those living in special housing.
RESULTS : The renal corticomedullary junction was clearly depicted in all patients.
RESULTS : The repeated measures models confirmed a significant association between the DS and total care cost indicating an increase in cost with increasing dependence.
RESULTS : The respondents had various motives to use ambient intelligence technologies to support ageing-in-place.
RESULTS : The respondents ' mean age was @number@ years.
RESULTS : The response rate of the first wave was @percent@ ( n = @number@ ) .
RESULTS : The response rate was @percent@.
RESULTS : The response rate was @percent@ ( @number@ of @number@ ) .
RESULTS : The response rate was @percent@ ( @number@ respondents ) .
RESULTS : The resulting Home Care Frailty Scale consisted of a final set of @number@ items.
RESULTS : The result of the system acceptance testing indicates that this developed system , implementing patient-centered services , is highly accepted by the elderly.
RESULTS : The results are that vitamin D and calcium supplementation reduce incidence of hip fractures.
RESULTS : The results confirmed previous works showing a detrimental effect of age on visuomotor learning.
RESULTS : The results demonstrated a significant correlation between lumbar extensor muscle strength , muscle fibre angle , age and gender.
RESULTS : The results demonstrated high interindividual variations.
RESULTS : The results from the IRT model showed that these four methods indicate strong unidimensionality so that they measure the same latent variable.
RESULTS : The results indicated that low therapeutic self-care ability was associated with an increase in adverse events.
RESULTS : The results indicated that self-perceptions of aging mediated the relationship between receipt of care and depressive symptoms.
RESULTS : The results indicated that the functionality was improved owing to the end-user evaluations.
RESULTS : The results of a chi-square test indicated that the double-blind test was conducted correctly.
RESULTS : The results of the studies analyzed in this review are not unambiguous.
RESULTS : The results of this study clearly reveal the importance of culture for all ageing perceptions among Turkish and Dutch elders.
RESULTS : The results of wound healing in vitro assay revealed a significant reduction of cell-free area time-dependent in ELF-EMF-exposed cells compared to Sham condition.
RESULTS : The results prove age-related differences in personality.
RESULTS : The results provide tentative evidence that meditation-based interventions do indeed improve levels of depression and burden in family dementia caregivers.
RESULTS : The results revealed maintenance of the training-induced inhibition gains at both follow-up sessions.
RESULTS : The results show age-related differences in the evaluation of life satisfaction.
RESULTS : The results showed associations between childhood living conditions , marital status , social class in adulthood and mortality during mid life.
RESULTS : The results showed increased IGFR-1 and MMPs protein levels in the PC and HGPIN groups.
RESULTS : The results showed increasing disability trends experienced by men , and stable or decreasing trends by women.
RESULTS : The results showed significantly higher failure loads for the augmented pedicle screws ( Median @number@ ± @number@ N , Min.
RESULTS : The results showed that education affects scores for some of the memory tests and the figure-copying task.
RESULTS : The results showed that @percent@ of the caregivers were females.
Results : The results showed that @percent@ of the subjects presented some degree of TMD.
RESULTS : The results showed that the fusion limits were significantly expanded ( p < 0.01 ) after inserting the middle image.
RESULTS : The results showed that the majority of respondents achieved high and medium levels of functional capability.
RESULTS : The results showed that the mean age of the participants was @number@ ± @number@ years old.
RESULTS : The results show strong associations for demographic and biological risk for both impairment groups.
RESULTS : The results show that Montessori activities have a significant effect on affect and on participation in the activity.
RESULTS : The results show that subjects taking Cynatine ( ® ) HNS showed statistically significant improvements in their skin when compared with placebo.
RESULTS : The results show that this method can be used in ages @number@ to @number@ years.
RESULTS : The results show the ability of just a few variables to sum up a reasonable model to apply to successful aging population.
RESULTS : The results suggested that changes in physical activities contributed to depressive symptoms which reflected positive affect in the later wave.
RESULTS : The results suggest that height is associated with high-grade prostate cancer risk.
RESULTS : The results underline a similar pattern of increasing difficulty of the tasks that explore ToM abilities in both the groups.
RESULTS : The results visualized structural and linguistic barriers to recruitment and study questionnaire administration , and describe strategies for how to bridge them.
RESULTS : The results were gathered by the traditional scoring method.
RESULTS : The retinol group showed significant photodamage improvement over vehicle at all timepoints during the study.
RESULTS : The review identified @number@ studies describing data from @number@ participants including @number@ dementia caregivers and @number@ non-caregiver peers.
RESULTS : There was a constant increase in the daily activity level during the research period.
RESULTS : There was a high intraclass correlation between repeated recordings of early supernormality , indicating excellent reliability of this VRC measure.
RESULTS : There was a linear relationship between both age and weight and CF.
RESULTS : There was an age-dependent increase in the membrane stability in relation to SDS.
RESULTS : There was an increase of collagen I and III immunoexpression in the elderly larynges , in both layers.
RESULTS : There was an upward trend in AMI mortality in both urban and rural populations that accelerated from @number@ onwards.
RESULTS : There was a reverse J-shaped relationship between total-T and risk for dementia ( P = .007 ) .
RESULTS : There was a sex-related dichotomy in the heat shock response to high external load training.
RESULTS : There was a significant age-dependent increase in S1PD , S2PD , and M2PD values ( P < @number@ ) .
RESULTS : There was a significant and parallel decrease of IGF-1 and SOS with age ( p < @number@ ) .
RESULTS : There was a significant association between wellbeing and COPD risk.
RESULTS : There was a significant difference between ED groups concerning MetS presence ( p = 0.032 ) .
RESULTS : There was a significant difference between the case and control groups in the XRCC1399 genotype.
RESULTS : There was a significant difference in age between the NER-Rs and the NER-NRs , with the NER-Rs being younger than the NER-NRs.
RESULTS : There was a significant interaction between OA and sex ( P = @number@ ) .
RESULTS : There was a significant interaction of diagnosis and age , and the education significantly influenced the total score for all CDT conditions.
RESULTS : There was a slight male preponderance.
Results : There was a small but significant test size-dependent sensitivity decline with age , with smaller stimuli declining more rapidly.
RESULTS : There was a statistically significant difference in both tongue pressure and the number of voluntary swallows between YAs and OAs.
RESULTS : There was a strong dose-response relation of plasma PLP concentration with plasma CRP.
RESULTS : There was a strong , statistically significant second-order polynomial relation ( P < @number@ ) between global peak systolic strain parameters and age.
RESULTS : There was excellent intrareader and interreader reproducibility for both QGS and 4D-MSPECT algorithms.
RESULTS : There was little socioeconomic patterning of PI from birth to @number@ years.
RESULTS : There was no death during perioperative period.
RESULTS : There was no difference between the groups in the amounts of exercise undertaken during the 8-week intervention period.
RESULTS : There was no difference in patient characteristics between the groups.
RESULTS : There was no group difference between sides ( repeated measures ANOVA , P = @number@ ) .
RESULTS : There was no overall effect of statin exposure on cerebral structural indices.
RESULTS : There was no salient correlation between objective and subjective QOL measures.
RESULTS : There was no significant age-related reduction in muscle fibre oxidative capacity.
RESULTS : There was no significant bone loss at the spine , femoral neck and total hip in premenopausal women.
RESULTS : There was no significant change in Hcy level after benazepril treatment for @number@ weeks ( P = @number@ ) .
RESULTS : There was no significant difference in transaminase levels from day @number@ to day @number@ after transplantation.
RESULTS : There was no significant difference in μTBS to conditioned dentin ( p > @number@ ) .
RESULTS : There was no statistically significant difference ( p > @number@ ) between sound and caries-affected dentin regardless of the storage condition.
RESULTS : There was significant correlation between the selected variables and the subjective global aging scale.
RESULTS : There was significantly higher serum high-sensitivity C-reactive protein ( hs-CRP ) , levels in patients with AD compared with healthy controls.
RESULTS : There was statistically significant association of age with impaired clinical , radiological presentation and outcomes in cases of SAH.
RESULTS : There were age group differences in overall cancer-related concern and specific cancer-related domains.
RESULTS : there were complete longitudinal data available for @number@ participants.
RESULTS : There were complete research clinic data from @number@ participants.
RESULTS : There were differences between values obtained from traditional and NCI methods , particularly in the lower and upper percentiles of the intake distribution.
Results : There were few significant associations in adjusted analyses.
RESULTS : There were individual differences in the PC counts both in the ET and the PD cases.
RESULTS : There were no associations between these SNPs and overall risk of prostate cancer.
RESULTS : There were no baseline differences across the three groups.
RESULTS : There were no baseline differences between groups.
Results There were no baseline differences in comorbidities or cytokines between survivors and the control group.
RESULTS : There were no cases of vitamin D deficiency among the studied population.
Results : There were no changes in glucose tolerance , insulin sensitivity , weight , blood pressure , or lipid profile following resveratrol treatment.
RESULTS : There were no clinically significant changes in clinical chemistry safety parameters.
RESULTS : There were no differences between genetic groups in behavioral task performance or neural activation in postincongruent versus postcongruent trials.
RESULTS : There were no differences between Polish and German subjects on temporal ordering.
RESULTS : There were no differences between younger and older adults in their use of the distal speech rate cue to word segmentation.
RESULTS : There were no differences in age , sex , or education between Optimal vs. Typical performers.
RESULTS : There were no group differences on pitch and melody discrimination tasks.
RESULTS : There were no immediate differences or a signi cant temperature rise with different passing techniques using the at or the fractional optic.
RESULTS : There were no missing data for pain and sleep measures , except for actigraphy , that generated several missing data.
RESULTS : There were no PJIs in our HIV population.
RESULTS : There were no significant age differences associated with sex or race.
RESULTS : There were no significant changes in weight , BMI , fat mass , or fat-free mass.
RESULTS : There were no significant correlations between emotional functioning and measures of effort.
RESULTS : There were no significant differences between genders , in both tests.
RESULTS : There were no significant differences between groups for changes in L-spine BMD ( primary outcome ) or the other skeletal sites of interest.
RESULTS : There were no significant differences between the age cohorts on the measures of intellect , language , or memory.
RESULTS : There were no significant differences between the @number@ groups with regard to the sex , ratio of cardiopulmonary arrest , and survival ratio.
RESULTS : There were no significant differences between the two age groups.
RESULTS : There were no significant differences between the two groups with regard to risk factors.
RESULTS : There were no significant differences in age among the four groups.
RESULTS : There were no significant differences in baseline characteristics and angiographic findings between the two groups.
RESULTS : There were no significant differences in patient-reported improvement in photodamage , overall skin quality , and postprocedure adverse events between treatment arms.
RESULTS : There were no significant differences in the socio-demographics of the patients.
RESULTS : There were no significant group differences in the QLI at baseline and follow-up.
RESULTS : There were no significantly difference among the materials and control groups after initial , @number@ h and @number@ week testing.
RESULTS : There were no significant racial group differences in sleep duration.
RESULTS : There were no statistically significant differences between the two groups at baseline.
RESULTS : There were no statistically significant differences in pre-exercise training pelvic floor muscle strength parameters among the three groups.
RESULTS : There were no statistically significant differences in the postural sway parameters between the two age groups.
RESULTS : There were notable health differences between the injured worker and comparator samples for the post-injury period.
Results : There were no treatment-emergent serious adverse events at 1-month postinfusion or significant donor-specific immune reactions during the first @number@ months.
RESULTS : There were @number@ and @number@ patients in the ABPC / SBT and AZM groups , respectively.
RESULTS : There were @number@ cases of malignant PNETs including functional malignant PNETs in @number@ cases and nonfunctional malignant PNETs in @number@ cases.
RESULTS : There were @number@ CHS participants from @number@ clinical sites.
RESULTS : There were @number@ deaths and the overall @number@ person-year death rate was @number@ ( @percent@ CI : @number@.37-4.22 ) .
RESULTS : There were @number@ deaths from CRC ( @percent@ for CC ) .
RESULTS : There were @number@ deaths , @number@ CVD deaths , @number@ CVD events , and @number@ CHD events during follow-up.
RESULTS : There were @number@ deaths ( @percent@ ) , including @number@ of IHD.
RESULTS : There were @number@ descriptive themes.
RESULTS : There were @number@ elective and @number@ emergency admissions.
RESULTS : There were @number@ eligible randomized controlled trials comparing Cerebrolysin with placebo.
RESULTS : There were @number@ ET cases and @number@ cases with dystonic tremor.
RESULTS : There were @number@ female ( @percent@ ) and @number@ males ( @percent@ ) .
RESULTS : There were @number@ hospitalizations involving @number@ of the @number@ individuals in the cohort ( @percent@ ) .
RESULTS : There were @number@ important results : ( i ) Patients with FLE showed weaker task switching abilities than healthy individuals.
RESULTS : There were @number@ incident cases of age-related cataracts during the mean @number@ years of follow-up ( @number@ person-years ) .
RESULTS : There were @number@ incident stroke events during a median follow up of @number@ years.
RESULTS : There were @number@ LTCI users among the @number@ previous service users ( @percent@ ) .
RESULTS : There were @number@ male and @number@ female patients of mean age @number@.3 + / -9 years.
RESULTS : There were @number@ @number@ and @percent@ per-decade declines in DAT in the caudate , putamen , and substantia nigra , respectively.
RESULTS : There were @number@ @number@ hospitalisations and @number@ fall-related trauma presentations.
RESULTS : There were @number@ @number@ responses to people aged @number@ years or older , constituting @percent@ of total emergency workload.
Results : There were @number@ participants aged 21-84 years with measures of hearing , visual , olfactory , and cognitive function at the baseline examination.
RESULTS : There were @number@ participants enrolled on this study ( median age @number@ ) .
RESULTS : There were @number@ participants ( @number@ men and @number@ women ) including @number@ ( @percent@ ) with diabetes at baseline.
RESULTS : There were @number@ participants ( @percent@ HIV-infected ) enrolled in the VACS-VC who also participated in the @number@ LHS.
RESULTS : There were @number@ participants ( @percent@ ) with low ABI ≤0.90 and @number@ ( @percent@ ) participants with borderline low ABI @number@.91-1.00.
RESULTS : There were @number@ patients included.
RESULTS : There were @number@ patients included.
RESULTS : There were @number@ patients initially treated non-operatively at V1.
RESULTS : There were @number@ patients who underwent major hepatectomy ( resection of @number@ or more segments ) from @number@ to @number@
RESULTS : There were @number@ patients with an average Acute Physiology and Chronic Health Evaluation II ( APACHE II ) score of @number@
RESULTS : There were @number@ patients with definite or probable IE according to modified Duke criteria.
RESULT ( S ) : There were @number@ patients with endometriosis who produced @number@ blastocysts that met the criteria for inclusion in the endometriosis group.
RESULTS : There were @number@ ( @percent@ ) deaths from all causes during the study period.
RESULTS : There were @number@ ( @percent@ ) females and @number@ ( @percent@ ) males.
RESULTS : There were @number@ ( @percent@ ) incident dementia cases during the follow-up.
RESULTS : There were @number@ ( @percent@ ) occurrences of incident PSLL and @number@ ( @percent@ ) deaths during median follow-up of @number@ years.
RESULTS : There were @number@ ( @percent@ ) persons with diabetes.
RESULTS : There were @number@ SSI cases reviewed.
RESULTS : There were @number@ subjects ( @percent@ women ) whose age was below @number@ in @percent@.
RESULTS : There were @number@ subjects with a mean ( SD ) age of @number@ ( @number@ ) years.
RESULTS : There were @number@ usable responses received ( response rate @percent@ ) .
RESULTS : There were @number@ women included for analyses ( mean age : @number@ years ) .
RESULTS : There were @percent@ participants reported neck or shoulder pain symptoms.
RESULTS : There were significant differences between participants ' general characteristics : age , education , religion , housing , hobby , and economic status.
RESULTS : There were significant differences between the automatic and manual methods regarding all volumes.
RESULTS : there were significant differences in the importance given to various aspects of QOL for people living in medium and high-development countries.
RESULTS : There were significant linear relationships between sural SNAP amplitude and HRDB with age.
RESULTS : There were significantly higher sensitization rate of UV-filter , octocrylene and the sunscreen in resurfacing group than in non-resurfacing group.
RESULTS : There were significantly higher serum hs-CRP levels in patients with PD compared with healthy subjects.
RESULTS : There were significant multivariate within-group , between-group , and interaction effects ( p < @number@ ) .
RESULTS : There were statistically significant higher CAVI values in ELC subjects ( @number@ ± @number@ vs. @number@ ± @number@ p < @number@ ) .
RESULTS : There were two main findings.
RESULTS : The rFTC values of controls remained fairly constant over time ( @number@ annual change ; @percent@ confidence interval , @number@.010-0.004 ) .
RESULTS : The RISE showed excellent convergent validity with the average time involved in activities ( r = @number@ ) .
RESULTS : The risk of progression to advanced AMD increased with increasing age ( P = @number@ ) and severity of drusen.
RESULTS : The risk of suicide ideation was @number@.43-1.65 times higher among participants with visual impairment than in those without impairment.
RESULTS : Thermal and pain thresholds of BMS patients did not differ significantly from those of healthy subjects.
RESULTS : The ROA group had worse KOOS scores but SCT and 6MWT were not different.
RESULTS : The rs8192678 PGC-1α SNP was not associated with the risk of PD.
RESULTS : The RT group presented reduced levels of log₁₀IFN-γ ( approx.
RESULTS : The SAFES cohort included @number@ patients , aged 85±6 years , with a majority of women ( @percent@ ) .
RESULTS : The safety profiles of these pharmacological agents are generally satisfactory in this patient segment provided a few precautions are followed.
RESULTS : The sagittal thickness of every nuclear core decreased until age @number@ years and remained constant thereafter.
RESULTS : The sample consisted of @number@ men and @number@ women with a mean age of @number@ ± @number@ years.
RESULTS : The sample included @number@ adults aged 45-95 years.
RESULTS : The sample included @number@ decedents.
RESULTS : The sample included @number@ elderly ( @number@ % female , mean age @number@ ± @number@ ) .
RESULTS : The sample included @number@ families and caregivers ( @percent@ adult children ) .
RESULTS : The sample included @number@ unrelated Chinese.
RESULTS : The sample included @number@ women and @number@ men , mean age @number@ years.
RESULTS : The sample presented generalized weakness in scapular ( mean @number@ ) and pelvic ( mean @number@ ) muscle.
RESULTS : The sample was composed of @number@ ( @percent@ ) females and @number@ ( @percent@ ) males.
RESULTS : The sample was primarily Caucasian ( mean age = @number@ ( SD = @number@ ) years ) .
RESULTS : The sample was representative for many socio-demographic factors but under-represented people not in the labour force and over-represented those with university qualifications.
RESULTS : The sample was representative of the German-speaking Swiss population as determined by @number@ census data.
RESULTS : The sarcopenia assumed a role of moderator in the adiposity-osteoporosis relationship.
RESULTS : The satisfactory goodness-of-fit indices confirmed that the factorial structure of WHOQOL-AGE comprises two first-order factors.
RESULTS : The SBRN was found to have 6-12 fascicles.
RESULTS : The scale consists of two subscales , each addressing one trade-off , with a total of @number@ items.
RESULTS : The SCREEN II score was significantly correlated with the dietitian's risk rating ( rs = @number@ ( p < 0.01 ) .
RESULTS : These adults on average spent 9h / d being sedentary during waking hours and @percent@ reported ADL disability.
RESULTS : The search ( @date@ - @date@ ) identified @number@ articles , of which @number@ were eligible for analysis.
RESULTS : The search found @number@ publications , with @number@ selected for full manuscript review.
Results The search generated @number@ articles and @number@ duplicates were discarded.
Results The search retrieved @number@ records.
Results : the search returned @number@ unique articles , of which @number@ met inclusion criteria.
RESULTS : These caregivers describe a tension that exists across their experiences and communication with authorities on whom they rely for guidance and collaboration.
RESULTS : The selected model had a R ( @number@ ) of @number@ and a RMSE of @number@ kg and fulfilled every regression assumption.
RESULTS : The self-adhesive resin cements exhibited higher microtensile bond strength than conventional cementing systems for all conditions studied.
RESULTS : The sensitivity of GPs to detect MCI was very low ( 11-12% ) whereas their specificity amounts to 93-94%.
RESULTS : The sensitivity of the TTCC was @percent@ and @percent@ for the very mild AD and aMCI groups , and the specificity was @percent@.
RESULTS : The sepsis mortality in small and medium-sized cities and rural areas declined obviously over time.
RESULTS : The series consist of @number@ patients who received a total of @number@ injections of L-polylactic acid.
RESULTS : The severity of dPVS was found to increase with age regardless of cerebral area ( p < 0.001 ) .
RESULTS : The shape of the pattern onset VEP changed gradually with age.
RESULTS : The similarities and differences between the salutogenesis , the OC and healthy learning were shown in a graph.
RESULTS : The six-month prevalence of PTSS was @percent@.
RESULTS : The skin grafts survived in all cases , and the incisions healed primarily.
RESULTS : The skin samples were shown to be viable and metabolically active.
RESULTS : The skull thickness increased with age at all sites measured.
RESULTS : The SMI showed an age-dependent decrease in both sexes.
RESULTS : The soluble Klotho concentration was lower ( p < 0.001 ) in patients with significant CAD ( n = 233 ) .
RESULTS : The Spanish P-CAT demonstrated good reliability , with an alpha coefficient of @number@ and a test-retest reliability coefficient of @number@
RESULTS : The Spanish version of the DQoL showed acceptable psychometric properties.
RESULTS : The spline estimate suggested increasing bone mineral density up to a calcium intake of about @number@ g / day and a plateau thereafter.
RESULTS : The SPPB summary score was associated with minutes of MVPA ( ρ = 0.16 , P = .001 ) .
RESULTS : The SRT was well-correlated with the dementia rating scales and the K-HVLT.
RESULTS : The SSR and NFL treatments provided comparable results for each skin attribute.
RESULTS : The start of the trial was delayed which caused subsequent time schedule problems.
RESULTS : The steady state UPE at the three skin sites increased with age.
RESULTS : The strength of the brackets decreased in Groups @number@ and @number@ but was not significant ( P = 0.635 ) .
RESULTS : The stress model proved to be a good fit to the data.
RESULTS : The strongest associations seen for both macroscopic and microscopic infarcts were risk variants associated with diabetes.
RESULTS : The strongest enrichments were observed for visuospatial attention and verbal abilities sets in bipolar disorder.
RESULTS : The structural equations model yielded acceptable results : χ² ( @number@ ) = @number@ p = @number@
RESULTS : The structure of CRAWS-CV was examined by exploratory principal component analysis with varimax rotation.
RESULTS : The students had enjoyed the placement and felt it had increased their understanding of the issues surrounding disability.
RESULTS : The studies demonstrated improvement in the quality of life and examined factors that predicted whether patients would return to work after OLT.
RESULTS : The study cohort consisted of @number@ patients ≥70 years ( mean = @number@ years , SE @number@ ) .
RESULTS : The study comprised @number@ participants ( aged 30-74 years ) and @number@ BP measurements.
RESULTS : The study comprised @number@ PD scans and @number@ control scans ( @number@ scans in total ) .
RESULTS : The study demonstrated significant differences involving the right / left side among the three age groups.
RESULTS : The study demonstrated that physical activity promotion through primary care has a high potential.
RESULTS : The study enrolled @number@ adults ( aged 26-94 years ) undergoing active treatment for cancer of any type.
RESULTS : The study enrolled @number@ patients.
RESULTS : The study enrolled @number@ patients , with at least @number@ in each decade between @number@ and @number@ years old.
RESULTS : The study enrolled @number@ subjects.
RESULTS : The study found a reduction in parvalbumin immunostaining in layer @number@ ( p = @number@ ) of the DLFPC in elderly depressed patients.
RESULTS : The study found @number@ geriatrician per @number@ elders , and @number@ geriatric psychiatrist per @number@ elders , in Texas.
RESULTS : The study group comprised @number@ adults who survived IPD.
RESULTS : The study group included @number@ deceased patients ; @percent@ died at home.
RESULTS : The study included @number@ control subjects and @number@ patients with ARC.
RESULTS : The study included @number@ men.
RESULTS : The study included @number@ patients.
RESULTS : The study included @number@ patients.
RESULTS : The study included @number@ patients.
RESULTS : The study included @number@ patients ( group I-149 , group II-132 ) .
RESULTS : The study included @number@ patients with OSAHS and @number@ healthy control subjects.
RESULTS : The study included @number@ subjects ( M : F 78 : 22 ) .
RESULTS : The study investigated @number@ consecutive modified SMAS face-lifting procedures.
RESULTS : The study manifested that hypertensives were associated with the reduction of LE , ALE and ALE / LE compared to the normotensives.
RESULTS : The study participants had an average of @number@ teeth lost.
Results : The study participants included @number@ ( @percent@ ) women and the average age of participants was @number@ ( @number@ ) years.
RESULTS : The study population comprised @number@ persons.
RESULTS : The study recruited @number@ consecutive patients ( median age : @number@ years ) .
RESULTS : The study revealed effective and durable correction of nasolabial wrinkles for periods of 9-12 months.
RESULTS : The study revealed @number@ low energy hip fractures ( @number@ in men @number@ and in women ) .
RESULTS : The study sample consisted of @number@ Medicare beneficiaries who contributed a total of @number@ person-year observations for analysis.
RESULTS : The study sample included @number@ cases who died and @number@ matched controls.
RESULTS : The study shows that many residents reviewed and thought about their lives , and that this aspect changed during the study period.
RESULTS : The study will provide new knowledge on nutritional self-care in home-dwelling older adults and the factors promoting nutritional self-care.
RESULTS : The subjects consumed an average of @number@ g protein / day representing @number@ g protein / kg body weight / day.
RESULTS : The subjects included in the statistical analysis were @number@ men and @number@ women.
RESULTS : The success rate of the root canal treatment was of @percent@.
RESULTS : The summary score that provided equal weight to each subtest best differentiated between the four cognitive states.
RESULTS : The survey response rate was @percent@.
RESULTS : The survey was completed by @number@ adults aged 50-93.
RESULTS : The svMCI group showed smaller orienting effect compared with the nvMCI and HC groups.
RESULTS : The Sweet @number@ correlated highly with the MMSE ( Spearman r , @number@ P < .001 ) .
RESULTS : The symptoms ' hectic fever ' and ' spontaneous sweating ' were found to be most relieved during R6 treatment.
RESULTS : The synthesis of eight qualitative studies indicated that health care professionals and administrators have identified factors that influence antibiotic prescribing in LTCFs.
RESULTS : The systematic large-scale analyses of @number@ human diseases create three classes of molecular connectivity maps.
RESULTS : The systematic review identified five papers ( three cross-sectional , one case control , and one longitudinal study ) .
RESULTS : The systematic search yielded @number@ abstracts.
RESULTS : The talar body , neck , and head were affected differently by age-related changes.
RESULTS : The task performance changed with age.
RESULTS : The thicknesses of the PL-biofilm after @number@ and @number@ days were not significantly different.
RESULTS : The three groups did not differ significantly in baseline characteristics or outcomes.
RESULTS : The three groups substantially differed in their involvement with initiating , and attitudes towards , transfer.
RESULTS : The three most common diagnoses were nystagmus ( @percent@ ) , cerebral visual impairment ( @percent@ ) and albinism ( @percent@ ) .
RESULTS : The three NHs had an average census of @number@ beds.
RESULTS : The time from symptom onset to surgery was significantly longer in the resection group than in the group without resection.
RESULTS : the time older adults walked increased with higher temperature , higher wind speed and the absence of rain.
RESULTS : The time to @percent@ survival for the full cohort ( N = 312 ) was @number@ months.
RESULTS : The T ( @number@ ) - and T ( @number@ ) -weighted-imaging-based scores were highly correlated.
RESULTS : The tool was valid and the inappropriate patient stay ( IPS ) score was @percent@.
RESULTS : The top health problem impacting our workplace partner was mental health.
RESULTS : The total direct cost of the intervention per participant was $ 459 , @percent@ of which was counselor effort.
RESULTS : The total number of individuals aged @number@ years and older was @number@ ( @number@ women , @number@ men ) .
RESULTS : The total occurrence rate of palmomental reflex was @percent@.
RESULTS : The total period of exposure to CZP was @number@ patient-years ( PY ) .
RESULTS : The total population consisted of @number@ participants , with @number@ CVD deaths.
RESULTS : The trained limb improved performance , facilitated MEPs and released SICI in both age groups.
RESULTS : The training group improved in four of the trained tasks ( medium-to-large effects ) .
RESULTS : The training group improved their gait performance under ST and DT conditions as revealed by significant group × time interaction effects.
RESULTS : The training group showed significant improvements in body sway during single-support balance and center of gravity alignment during double-support dynamic balance.
RESULTS : The training was deemed easily usable and acceptable by senior users.
RESULTS : The transverse blepharotomy was successful in @number@ cases ( @number@ % ) as a primary surgical intervention.
RESULTS : The treated subjects experienced significantly improved skin complexion and skin feeling , profilometrically assessed skin roughness , and ultrasonographically measured collagen density.
RESULTS : The treatment group showed significant improvements in passive hip extension range of motion ( P = @number@ ) .
RESULTS : The trends of crude and age-standardized mortality from prostate cancer in the general population increased significantly ( P < @number@ ) .
RESULTS : The two clinical samples had significantly longer AR CAG repeats and higher depression levels compared with the CS.
RESULTS : The two groups resulted homogenous about age , sex , operative time , short-term post-operative complications.
RESULTS : The two groups were similar on reported physical activity and on the Mini-Mental State Examination ( MMSE ) .
RESULTS : The two studied groups showed comparable demographic data and years of work.
RESULTS : The two-week prevalence of attempted suicide in the elderly was @percent@.
RESULTS : The unadjusted follow-up mortality was @percent@ and @percent@ among the users and non-users of DAPs , respectively ( p = @number@ ) .
RESULTS : The underlying structural changes in the collagen network of young and aged sun-exposed facial skin in vivo were visualized by MPLSM.
RESULTS : The UPSA-M was feasible for use among middle aged and older adults with schizophrenia with no prior history of tablet usage.
RESULTS : The up-slanting lower eyelid margin was lowered and the lateral part of the palpebral aperture was enlarged by the procedure in all cases.
RESULTS : The USCT was evident as a string-like tissue structure in multiparous women or a thick mesh in nuliparous women.
RESULTS : The use of TCA to estimate CA was successful for most individuals.
RESULTS : The V / 4 isopter area decreased from age @number@ and the I / 4 isopter area decreased significantly from age @number@
RESULTS : The values describing lumbar lordosis increased linearly with years of training and were significantly greater than those reported in the literature.
RESULTS : The volume of OFC decreased with age and significantly correlated with age-related declines in olfactory function.
RESULTS : The water-based program provided a similar improvement in dynamic strength in comparison with resistance training.
RESULTS : The WAT showed a significant independent effect on cognitive scores , generally greater than that predicted by demographics.
RESULTS : The WC , WHtR , and LAP indicators showed the highest AUC , with values greater than @number@
RESULTS : The women's mean age was @number@ @percent@ were college graduates , @percent@ had a partner , and @percent@ were non-Euro-American.
Results : The XbaI @number@ AA genotype was more common among cognitive decliners , while -351G allele carriers showed cognitive stability or improvement.
RESULTS : The young group comprised @number@ ( @percent@ ) patients aged @number@ y or younger with a median age of @number@ y.
RESULTS : They will be presented in articles to follow.
RESULTS : thirteen of @number@ studies identified were included in the meta-analysis.
RESULTS : Thirteen percent of the study population reported one or several falls in the measured period.
RESULTS : Thirteen studies reported in @number@ articles were included in the review.
RESULTS : Thirteen studies were included in the review , @number@ longitudinal , prospective study and @number@ cross-sectional studies.
RESULTS : Thirty articles met the inclusion criteria.
RESULTS : Thirty C4-C5 IVDs and thirty C5-C6 IVDs were macroscopically examined for degeneration.
RESULTS : Thirty cases with clinical diagnosis of parkinsonism ( onset ≥80 years ) came to autopsy.
RESULTS : thirty-day mortality was @number@ ( @percent@ ; @percent@ confidence interval ( CI ) = 10-15% ) of whom @number@ died in hospital.
Results : Thirty-eight reports were identified.
RESULTS : Thirty-eight sleep , demographic and clinical correlates of sleep quality were considered.
RESULTS : Thirty-eight studies were identified that met the inclusion criteria.
RESULTS : Thirty-five HIV-positive patients with diabetes or hypertension participated.
RESULTS : Thirty five papers were included in this review.
RESULTS : Thirty-five papers were selected , with a total of subjects @number@ studied.
RESULTS : Thirty-five subjects were enrolled with a mean age of @number@ years ; @number@ subjects completed the study.
RESULTS : Thirty-four of @number@ selected SNPs were successfully genotyped in @number@ men.
RESULTS : Thirty-four of the cases were diagnosed as organic ED , and the other @number@ as psychological ED.
RESULTS : Thirty-four of these patients had at least one occluded artery , and @number@ % of them had at least one hospital admission.
RESULTS : Thirty four patients died at home under Zaitaku care , and @number@ patients died in the hospital during this period.
Results : Thirty-four preclinical and @number@ clinical studies were identified from database searches.
RESULTS : Thirty four subjects with aMCI and @number@ naMCI met study criteria.
RESULTS : Thirty individuals ( @number@ females and @number@ males ) participated in the study , ranging in age between @number@ and @number@ years.
RESULTS : Thirty of the treated patients have had follow-up for @number@ years at this time.
RESULTS : Thirty-one articles met the inclusion criteria.
RESULTS : Thirty-one patients received percutaneous mesenteric interventions during this period.
Results : Thirty-one samples of cSCC from @number@ patients were analyzed.
RESULTS : Thirty-one transfused critically ill children and eight healthy controls were studied.
RESULTS : Thirty participants ( @percent@ ) reported concealing their diagnosis in the previous month , most frequently from casual friends and close friends.
RESULTS : Thirty patients were injected with a mean dose of @number@ U of abobotulinumtoxinA per patient.
RESULTS : Thirty-seven articles were included.
RESULTS : Thirty-seven cohort studies were identified and included in this review : @number@ on comorbidity and @number@ on frailty.
RESULTS : Thirty-seven PD patients participated in the study.
RESULTS : Thirty-seven responses were received from the @number@ countries approached , representing an @percent@ response rate from members.
RESULTS : Thirty-six articles were selected , of which @number@ were included after critical reading.
RESULTS : Thirty studies were included.
RESULTS : Thirty subjects aged 40-65 years were enrolled.
RESULTS : Thirty subjects completed the study.
RESULTS : Thirty subjects were assessed.
RESULTS : Thirty-three articles reporting imaging findings for @number@ asymptomatic individuals met our study inclusion criteria.
RESULTS : Thirty-three farm household individuals ( including @number@ couples ) participated.
RESULTS : Thirty-three of @number@ patients ( @percent@ ) exhibited corrected QT ≥450 ms.
RESULTS : Thirty-three patients meeting eligibility criteria were enrolled , with equal numbers of subjects using latanoprost , travoprost , and bimatoprost.
RESULTS : Thirty-three percent of participants had 25 ( OH ) D < 20ng / mL.
RESULTS : Thirty-two laboratory studies fulfilled the inclusion criteria comprising @number@ experiments.
RESULTS : Thirty-two percent experienced auditory verbal hallucinations.
RESULTS : Thirty-two studies met the inclusion criteria ; these studies included @number@ individuals with an average follow-up of @number@ y.
RESULTS : thirty volunteers of mean age @number@ ± @number@ years and @number@ volunteers of mean age @number@ ± @number@ years were recruited.
RESULTS : This interdisciplinary , theory-based , patient-centered design approach produced a prototype for field-testing in six months.
RESULTS : This paper describes the development of the self-screening instrument and summarizes findings relative to increasing self-awareness among older drivers.
RESULTS : This review highlights that a single evaluation method often is not adequate for understanding why people adopt ICTs for aging in place.
RESULTS : This sample reported moderately permissive attitudes toward aging sexuality , indicating a low level of aging sexual stigma.
RESULTS : This study confirmed a priori hypotheses of @number@ latent cognitive domains in a unique longitudinal sample of cognitively normal adults.
RESULTS : This study derived @number@ insights , @number@ categories , @number@ themes , a conceptual framework , some potential solutions , and a prototype.
RESULTS : This study enrolled @number@ patients ( age @number@ ± @number@ years , @percent@ female ) who underwent PD.
RESULTS : This study enrolled @number@ secondary rhytidectomy patients.
RESULTS : This study has outlined the overall relationship between the electrocardiographic abnormalities and advancing age.
RESULTS : This study included @number@ eyes of @number@ normal subjects and @number@ eyes of @number@ glaucoma patients.
RESULTS : This study included @number@ individuals , with a mean age of @number@ years and @percent@ of whom were female.
RESULTS : This study included @number@ subjects ( mean age of @number@ ± @number@ years ) .
RESULTS : This study includes @number@ youth who entered the SIPP with insurance and became uninsured.
RESULTS : This study investigated the effects of EMS on TNF-α-induced MMP-1 expression in HDFs.
RESULTS : This study reports on @number@ persons aged @number@ years and above ( @percent@ men ) .
RESULTS : This technique takes approximately @number@ minutes per earlobe to complete.
RESULTS : This training method had a significant effect for patients with articulation disorders.
RESULTS : Those in the AG were younger and healthier , with fewer chronic diseases and fewer depressive symptoms than those in the IG.
RESULTS : Those variables hypothesized to predict the course of early-stage MCI patients were most predictive for MCI progression.
RESULTS : Those with a mental disorder had a significantly lower mean pre-morbid IQ score than those without.
RESULTS : those with limitations in physical functioning at baseline more frequently reported subsequent disability.
RESULTS : Three clusters were identified.
RESULTS : Three cross-sectional and @number@ prospective studies were identified.
RESULTS : Three dietary classes emerged : Western , Healthy and Low-Energy.
RESULTS : Three disability trajectories maintained function , progressive disability , and consistent disability were identified.
RESULTS : Three distinct trajectories of cognitive change were identified and characterized as stable , slow decline and rapid decline.
RESULTS : Three factors were identified ; Cronbach's alpha was @number@.83-0.86 for negative impact and @number@.77-0.78 for quality of support , indicating good internal consistency.
RESULTS : Three hundred and forty-eight eyes from @number@ children aged @number@ years to @number@ years were imaged.
RESULTS : Three hundred and sixteen patients ( mean age @number@ SD @number@ years ) were included ( @number@ % females ) .
RESULTS : Three hundred and sixty-seven subjects with overweight and obesity were included.
RESULTS : Three hundred and twenty-eight participants underwent autopsy ; @number@ ( @percent@ ) had AF.
RESULTS : Three hundred fifty-four deaths occurred within @number@ months of two sequential life-space assessments.
RESULTS : Three hundred fifty patients were enrolled.
RESULTS : Three hundred seventy-three treatments resulted in @number@ AEs ( @percent@ ) in @number@ patients ( @percent@ ) .
RESULTS : Three hundred thirty-nine men from Manchester and @number@ from Leuven , mean ages @number@ and @number@ years , respectively , participated.
RESULTS : Three main themes emerged from the interviews.
RESULTS : Three out of four games showed adequate results on AFR , CV , and DV measures.
RESULTS : Three overarching themes emerged : ( @number@ ) Functional changes included increasing body awareness , movement memory and functional skill.
RESULTS : Three papers were agreed as top-ranking.
RESULTS : Three preclinical stages of AD were proposed : asymptomatic amyloidosis , asymptomatic amyloidosis + neurodegeneration , amyloidosis + neurodegeneration + subtle cognitive decline.
RESULTS : Three-quarters of residents maintained or improved their basic social skills during both the time periods.
RESULTS : Three randomized controlled trials evaluating @number@ participants were included.
RESULTS : Three randomized control trials and six case series were included.
RESULTS : Three rounds of the Delphi identified twenty-six separate important issues.
RESULTS : three studies involving @number@ participants were included.
RESULTS : Three studies reporting on new technologies and one on a group work intervention identified significant reductions in loneliness.
RESULTS : Three superficial ( one central and two lateral ) and three deep ( one central and two lateral ) forehead compartments were identified.
RESULTS : Three themes emerged.
RESULTS : Three themes emerged : ' Dislike being alone' ; ' Loneliness and isolation' ; and ' Social isolation causes negative feelings'.
RESULTS : Three themes emerged : ( @number@ ) ' What is my worth ? '
RESULTS : Three trajectory groups were identified : maintaining nonfrailty , developing frailty , and high risk of frailty.
RESULTS : Throughout the 19-month study period , @number@ patients received @number@ treatments with an average follow-up of @number@ months.
RESULTS : Through the methodological approach , conflicts in the environment created by missing or inadequate elements were identified.
RESULTS : TIA , TK , and C2-C7A were found to markedly increase with age from late middle age ( P < @number@ ) .
Results : Time in bed restriction decreased sleep duration and increased objective and subjective daytime sleepiness.
RESULTS : Time trends of @number@ out of the @number@ activity limitation variables studied were stable.
RESULTS : T-lymphocyte-secreted IL-17 from aging-mimic mice induced NF-κB activity and target gene expression in LNCaP and RWPE-1 cells.
RESULTS : To address this challenge , we developed a method , implemented as a Cytoscape plugin called ExprEssence.
Results to date confirm only a few gene variants associated with longevity , while others show inconsistent results.
RESULTS : To evaluate this possibility , we performed a bioinformatic screen for the existence of compound regulatory elements in the human genome.
RESULTS : Tolerance of the two methods is reasonably good with better results for the IPL treatment.
RESULTS : Topics included SCD inclusion and exclusion criteria , together with the informant's role in defining SCD presence and the impact of demographic factors.
RESULTS : Total average intervention cost was $ 941.63 per day.
RESULTS : Total BASMI scores ranged from @number@ to @number@ with only @percent@ of the sample having a score of @number@
RESULTS : Total cognition score is not associated with cancer survivorship.
RESULTS : Total IGF1 levels were higher in females ( P = 0.048 ) .
RESULTS : Total IIEF and AMS scores were significantly improved during the @number@ weeks of treatment in both groups.
RESULTS : Totally , @number@ active intestinal BD patients were enrolled.
Results Totally @number@ CEA procedures were estimated : @number@ ( ESRD ) ' @number@ ( CKD ) ' and @number@ ( NF ) .
RESULTS : Totally , @number@ normal recordings belong to @number@ patients were included.
RESULTS : Totally , @number@ studies met the inclusion criteria , with @number@ participants.
RESULTS : Totally , @number@ studies were included after screening , which involved @number@ @number@ cases.
RESULTS : Total maxillary sinus volume was significantly smaller in completely and partially edentulous patients than in dentate subjects.
RESULTS : Total number of registered deaths was @number@ and @number@ ( @percent@ ) were classified as cases of dementia-related mortality.
RESULTS : total of @number@ men was interviewed , mean age @number@ years.
RESULTS : Total of @number@ PILs were analysed involving @number@ drug substances for the treatment of cardiovascular disease and type @number@ diabetes.
RESULTS : Total sperm count and sperm concentration were decreased in men with elevated serum PSA compared with age-matched controls.
RESULTS : Traffic pollution was not associated with mean parasympathetic tone and LF / HF for all examined moving averages.
RESULTS : Training attendance was @number@ % and the prescribed intensity of load was realised by the participants in the IG.
RESULTS : Training benefits emerged in the trained group for the tasks that were practiced.
RESULTS : Training resulted in improved reasoning performance through Year @number@
RESULTS : Tramadol plasma time-concentration profile changes with postmenstrual age.
RESULTS : Transepidermal water loss decreases slightly with age , which is partially explained by the age-dependent increase in SC thickness.
RESULTS : TREAT accepted @number@ geriatric admissions over a 12-month period , of which @percent@ were discharged on the day of admission.
RESULTS : Treatment A produced statistically significantly greater improvements in skin tone evenness , skin tone clarity , and blemishes and blotchiness.
RESULTS : Treatment with API-2 resulted in downregulation of cyclin D1 expression in cells with acquired radioresistance.
RESULTS : Treatment with BTX-A exhibited significant sebum alteration at the injection site of both groups , with a sebum gradient surrounding the injection point.
RESULTS : Trend analyses.
RESULTS : Trials enrolled @number@ participants ( @percent@ female , mean age at randomization = @number@ years ) .
RESULTS : Tr , Tsk , %HRmax , CVC and Msw were similar across age groups both pre and post heat acclimation.
RESULTS : Trypsin-1 and trypsin-2 were detected in the vitreous.
RESULTS : TTR was correlated negatively with age ( r = -0.30 , p < 0.001 ) .
RESULTS : Tumour tissue samples from @number@ patients with breast cancer were included.
RESULTS : twelve articles had an identified population or subpopulation aged @number@ years and older.
RESULTS : Twelve differentially expressed proteins were identified.
RESULTS : Twelve individuals with dMCI progressed clinically , and @number@ individuals remained stable over @number@ years.
RESULTS : Twelve-month all-cause mortality was @percent@.
RESULTS : Twelve older adults ( @number@.5±4.2 years old ) performed light intensity exercise with Jintronix for a total of @number@.9±7.9 minutes per week.
RESULTS : Twelve percent of the COHS was edentulous.
RESULTS : Twelve studies ( five quantitative , three qualitative and four mixed methods ) met the criteria for inclusion in the review.
RESULTS : Twelve studies involving @number@ participants were included.
RESULTS : Twelve studies were included.
RESULTS : Twelve studies were included in the review.
RESULTS : Twelve studies were included , reporting a large diversity of interventions in terms of content , duration , and follow-up period.
RESULTS : Twelve-year mortality rates were 133 / 242 ( @percent@ ) in men and 92 / 235 ( @percent@ ) in women.
RESULTS : Twenty-eight adults with T2DM reported using a blood glucose meter , and almost half reported monitoring their blood pressure.
RESULTS : Twenty-eight healthy human subjects from ages 20-82 years were enrolled as donors for FMT.
RESULTS : Twenty-eight kidney-tonifying herbal medicines with anti-aging effects and @number@ related target proteins were collected.
RESULTS : Twenty-eight women ( median age @number@ years ) were included in the analysis.
RESULTS : twenty-five participants were randomised to the intervention group and @number@ to the control group.
RESULTS : Twenty-five percent of the elderly women were classified as normal weight , @percent@ overweight , and @percent@ obese by the BMI.
RESULTS : Twenty five studies reporting on a total of @number@ elderly Brazilians were included.
RESULTS : Twenty-five women ( mean age @number@ years ) were included in the study.
RESULTS : Twenty-four consecutive patients were included , allowing follow-up of @number@ areas.
RESULTS : Twenty-four data sets with information on full MNA classification from researchers from @number@ countries were submitted.
RESULTS : Twenty-four eyes of @number@ patients ( n = @number@ HIV-positive and @number@ HIV-negative ) were imaged with the adaptive optics camera.
RESULTS : Twenty-four hour Uvols ranged from @number@ to @number@ mL , whereas the Uosm varied between @number@ and @number@ mOsm / kg.
RESULTS : Twenty-four injured elderly subjects were enrolled : mean injury severity score @number@ average age @number@ years , @percent@ survival , @percent@ blunt trauma.
RESULTS : Twenty-four percent ( n = @number@ ) of patients admitted during the study period were identified as presenting with mild functional deficits.
RESULTS : Twenty-nine MCI patients progressed and @number@ remained stable.
RESULTS : Twenty nine of forty six subjects responded to the survey with a response rate of @percent@.
RESULTS : Twenty-nine of @number@ subjects successfully completed the study.
RESULTS : Twenty-nine out of @number@ older subjects showed evidence of a double peak-shaped CIP waveform that could be interpreted as ocular pulse dicrotism.
RESULTS : Twenty-nine patients participated in interviews prior to , and @number@ and @number@ months post following TJR.
RESULTS : Twenty-nine percent reported no LTPA , whereas @percent@ performed moderate-to-heavy intensity LTPA.
RESULTS : Twenty-nine studies representing @number@ @number@ patients from @number@ unique cohorts were included.
RESULTS : Twenty-nine trials were identified for data extraction.
RESULTS : Twenty-one articles met the criteria and were included in the review.
RESULTS : Twenty-one depression attributes were identified and @number@ were present in at least @percent@ of the interviews.
RESULTS : Twenty-one percent of the study participants developed new infarcts.
RESULTS : Twenty-one studies were included.
RESULTS : Twenty participants , mean age @number@ ± @number@ years , participated.
RESULTS : Twenty patients completed the study.
RESULTS : Twenty patients had CRP-levels below @number@ mg / L before surgery and low levels of the additional inflammatory markers.
RESULTS : Twenty patients with @number@ TLHIs were analyzed.
RESULTS : Twenty ( @percent@ ) individuals had subclinical hypothyroidism and five ( @percent@ ) had subclinical hyperthyroidism.
RESULTS : Twenty percent of older adults reported rehabilitation use in the last year.
RESULTS : Twenty-seven patients were included with a mean follow-up of @number@ months.
RESULTS : Twenty-seven percent to @percent@ of the cohort was eligible for cardiovascular disease risk intervention , depending on the risk model used.
RESULTS : twenty-seven randomised controlled trials ( RCTs ) were identified ; seven trials were excluded.
RESULTS : Twenty-seven studies met the inclusion criteria.
RESULTS : Twenty seven thousand , five hundred and fourteen patients were admitted into the medical wards.
RESULTS : Twenty-six cases were performed successfully , and @number@ cases were converted to open procedure.
RESULTS : Twenty-six observational and three intervention studies ( n = 19-9 , 556 ) were included in the meta-analysis.
RESULTS : Twenty-six participants were treated for a minimum of @number@ years.
RESULTS : Twenty-six postmenopausal women were enrolled ( symptomatic : n = @number@ asymptomatic : n = @number@ ) .
RESULTS : Twenty-six surrogate / patient pairs ( @number@ per study arm ) were enrolled.
RESULTS : Twenty-three individuals ( mean ± S Falls on stairs are a major hazard for older adults.
RESULTS : Twenty-three ( @number@ % ) of the @number@ women fulfilled the diagnostic criteria for presarcopenia whereas @number@ ( @number@ % ) were sarcopenic.
RESULTS : Twenty-three papers were evaluated searching for sex differences in the prevalence of MetS and CV risk.
RESULTS : Twenty-three patients with a clinically significant incisional hernia and @number@ control patients were included.
RESULTS : Twenty-three percent of participants had limited literacy ( < 9th-grade level ) .
RESULTS : Twenty-three publications , including @number@ @number@ participants , from more than @number@ different countries were identified for inclusion in this review.
RESULTS : Twenty-three studies were included.
RESULTS : Twenty-two intervention studies and five web-based campaigns were included in the review.
RESULTS : Twenty-two manuscripts were identified reporting on @number@ unique studies.
RESULTS : Twenty-two older adults and older adults diagnosed with Parkinson's disease tolerated the intervention by completing all @number@ sessions.
RESULTS : Twenty-two participants enrolled : @number@ ( mean [ SD ] age : @number@ [ @number@ ] ) completed CR.
RESULTS : Twenty-two patients received the tinted IOL and @number@ the untinted IOL.
RESULTS : Twenty-two percent of residents were referred to hospice.
RESULTS : Twenty-two prepubertal TS patients had delayed bone age , were shorter and lighter than controls ( Ps < @number@ ) .
RESULTS : Twenty-two studies were included.
RESULTS : Twenty-two studies with @number@ patients were identified.
RESULTS : Twenty-two volatile aldehydes were identified and determined in the samples.
RESULTS : Two cohort and twenty-nine case-control studies were eligible.
RESULTS : Two consistent correlations between diet and hearing were observed.
RESULTS : Two dichotomous overarching themes were identified.
RESULTS : Two dimensions of pain were identified : physical pain and pain as suffering.
RESULTS : Two fTIC patterns were identified.
RESULTS : Two hundred and fifty-eight patients were identified for analysis.
RESULTS : Two hundred and fifty-one and @number@ cases of oxazepam and nordiazepam poisonings were included , respectively.
RESULTS : Two hundred and five ( @percent@ ) participants stopped driving over the study period.
RESULTS : Two hundred and ninety residents met the inclusion criteria.
RESULTS : Two hundred and seventy-two participants ( @percent@ ) were classified as obese and forty-one ( @percent@ ) were as breakfast skippers.
RESULTS : Two hundred and sixty GPs enrolled @number@ evaluable patients between @date@ and @date@ .
RESULTS : Two hundred and thirty-five ≥ 60-year-old subjects were studied.
RESULTS : Two hundred and thirty-nine patients were identified , with @number@ patients receiving treatment.
RESULTS : Two hundred fifty-five ( @percent@ ) participants experienced @number@ readmissions.
RESULTS : Two hundred fifty-seven residents responded to the survey.
RESULTS : Two hundred forty-one ( @percent@ ) participants had 25 ( OH ) D levels lower than @number@ ng / ml.
RESULTS : Two hundred ninety-one patients underwent at least 1-6 injections of PMMA microspheres into bilateral under eye area.
RESULTS : Two hundred sixty-nine patients ( @number@ eyes ) were recruited.
RESULTS : Two hundred sixty-three patients with a mean age of @number@ ( 50-95 ) were examined.
RESULTS : Two hundred three of @number@ men and @number@ of @number@ women had > or = 2 metabolic risk factors.
RESULTS : Two known loci at GCK rs730497 ( or rs2908282 ) and HK1 rs17476364 were confirmed ( p < 5e-8 ) .
RESULTS : Two MA and two SE were unable to complete the magnetic resonance imaging ( MRI ) study.
RESULTS : Two main and six sub-themes emerged.
RESULTS : Two main themes were identified : ' Recognising the Problem ' and ' Service Availability and Access'.
RESULTS : Two overarching notions were illuminated.
RESULTS : Two percent of the respondents felt proxy consent should never be allowed.
RESULTS : Two thirds of respondents expected to need LTSS , but few reported saving for such services.
RESULTS : Two thousand and fifty-eight ( @percent@ ) participants were physically active at study entry.
RESULTS : two thousand four hundred and four ( @number@ men ; @number@ women ) participants were recruited.
RESULTS : Two thousand , one hundred and forty-one participants were followed from @date@ to @date@ .
RESULTS : Two thousand three hundred forty-nine ( @percent@ ) reported a history of cancer.
RESULTS : Two-way ANOVA revealed that only the aging condition significantly affected the bond strength to zirconia.
RESULTS : UC had the highest contact angle ( @number@.4° ) , whereas HF10 showed the lowest contact angle ( @number@.5° ) .
RESULTS : UI was reported in @percent@ of the participants.
RESULTS : Unadjusted metabolic syndrome prevalence was @percent@.
RESULTS : Under dark adaptation , both methods revealed reduced OP amplitudes and prolonged implicit times by @number@ years of age.
RESULTS : Under each criteria set , single-domain amnestic MCI was the most frequent MCI diagnosis.
RESULTS : Under Medicare , almost @number@ % of women with any BCCP use were re-screened versus @number@ % of non-BCCP users.
Results underscore the importance of the positive aspects of caregiving such as finding meaning as potential buffers of the burden of caregiving.
RESULTS : Unlike PSM , ABM differentiated between diagnostic categories but did not relate to AD biomarkers.
RESULTS : Unplanned readmission rates were @percent@ , @percent@ and @percent@ after @number@ @number@ and @number@ days , respectively.
RESULTS : Unusual sleep postures were recorded in @number@ ( @percent@ ) people with DS.
RESULTS : Up to @number@ the incidence of all cancers combined is expected to decrease slightly for both sexes.
RESULTS : Urban Chinese elders ' living arrangement had transited from a traditional intergenerational co-residence pattern to a more self-independent style.
RESULTS : Urinary mannitol exhibited significantly different kinetics than lactulose and sucralose which were similar to each other and varied little over the 24h.
RESULTS : Using a cut score of @number@ the sensitivity of the PHQ-2 was @number@ and the specificity was @number@
RESULTS : Using a linear mixed model , differential expression with age was identified in @number@ genes in skin and @number@ genes in adipose tissue.
RESULTS : Using a robust hierarchical regression , the study found that neuroticism and hopelessness were significantly associated with suicidal ideation.
RESULTS : Using continued abstinence as the outcome measure showed that telephone counseling had the highest probability of being cost-effective.
RESULTS : Using generalized linear modelling , we examined associations between tinnitus ( mild to severe ) and symptoms of depression and anxiety.
RESULTS : using inertial sensor data , participants were classified as frail or non-frail with mean accuracy of @percent@ ( stratified by gender ) .
RESULTS : Using western blots and immunohistochemistry , we found that CSPalpha expression is reduced in hippocampus and superior temporal gyrus in Alzheimer's disease.
RESULTS : Using Winblad criteria , @number@ participants were classified as having MCI and @number@ as cognitively normal ( CN ) .
RESULTS : Usual endpoints actually recommended for drug development suffer from important flaws.
RESULTS : UVA irradiation raised the proportion of SA-β-gal-positive cells in comparison with the normal control group ( P < 0.05 ) .
RESULTS : Vacuoles were found in capillary basement membranes at the vessel-glia interface in all samples , from both the normal and disease cases.
RESULTS : Valid information was provided by @number@ individuals at all three time points.
Results varied across levels of spatial scale.
RESULTS : Various features are found , most often cognitive symptoms.
Results vary in the acute inflammatory phase and are scarce when sclerosis and atrophy have already been established.
RESULTS : Vascular and extravascular fractions of ICAM-1 immunoreactivity were lower in subjects with MDD than in non-psychiatric comparison subjects.
RESULTS : VAT and VAT% were higher in EA than AA women ( p < @number@ ) .
RESULTS : VD was reported in @number@ ( @percent@ ) patients while CP was detected in @percent@ patients.
RESULTS : Vertebral angles were different depending on location.
RESULTS : Veterans report higher sleepiness than normal controls.
RESULTS : V · E values during pre-PWM QS were calculated as 1-minute averages using data obtained between @number@ and @number@ minutes.
Results : Visual acuity measurements were available for @number@ ( @percent@ ) participants.
RESULTS : Visual conditions and lighting design have an impact on work performance in those over age @number@ even if there are few studies available.
RESULTS : Visual selective attention was influenced by aMCI , auditory cues , and task characteristics.
RESULTS : Visuo-haptic subjective vertical was correctly predicted by the model in healthy participants , as well as in patients in spite of different performances.
RESULTS : Vitamin D deficiency was evident in @number@ ( @percent@ ) patients.
RESULTS : Vitreomacular adhesion is defined as perifoveal vitreous separation with remaining vitreomacular attachment and unperturbed foveal morphologic features.
RESULTS : VO2max and gender significantly affected number of CPM at different PA intensities ( p < @number@ ) .
RESULTS : Volunteers with an average education showed longer times on the WEFT than those with a higher education.
RESULTS : Walking speed deteriorated with increasing severity of COPD.
RESULTS : Walking speed was slower during DTW compared with normal walking ( p < @number@ ) .
RESULTS : Washington State and national data were similar.
RESULTS : Wave aberration measurements were highly reproducible.
RESULTS : WBC counts were significantly different between subjects with and without MetS in both genders.
RESULTS : We analysed colonic mucosal biopsies in @number@ normal individuals and demonstrated that in most individuals promoter hypermethylation was not quantified for MYOD-1.
RESULTS : We analysed @number@ @number@ @number@ hospitalizations.
RESULTS : We analysed @number@ persons with a mean follow-up of 18±5.5 years.
RESULTS : We analyzed gene expression with microarrays in baboon aortas , and found that members of the HOX gene family exhibited spatial expression differences.
RESULTS : We applied discriminant function analysis to identify the factors associated with different ages at menopause.
RESULTS : We applied the proposed method to the genome-wide association analysis of Alzheimer's disease.
RESULTS : We argue that the motivational theory of lifespan development , which focuses on control , is particularly relevant to late life suicide.
RESULTS : We categorized ferritin in sex-specific quartiles.
RESULTS : We chose the hyaluronic acid for the methodization of education.
RESULTS : We confirmed APOE ε4 as a strong risk factor for AD.
RESULTS : We confirmed that the mRNA and protein expression levels of PlGF significantly decreased following subculture of the cells.
RESULTS : We confirmed the dye affinity of CV to MP in all tested models.
RESULTS : We confirm the associations between the minor allele of the SNP and higher triglycerides and lower glucose levels.
RESULTS : We constructed a binomial model to investigate the association between a metabolic syndrome index and DNA methylation in the Normative Aging Study.
RESULTS : We constructed multivariable linear regression models evaluating both outcomes.
RESULTS : We constructed the PPI network of autophagy in P. anserina based on the corresponding networks of yeast and human.
RESULTS : We demonstrated that human HDL is susceptible to glycation by MG ( @number@.2mmol / L and 1mmol / L ) .
RESULTS : We demonstrate here the role of aging , of inosine and of the IL-2 receptor γ mutation in controlling P. falciparum induced inflammation.
RESULTS : We demonstrate that TPL2 deletion does not alter body weight gain or adipose depot weight.
RESULTS : We described the clinical , radiological and pathological characteristics of our case and we make a comparison of what previously described in literature.
RESULTS : We determined the age-related reference intervals of grip strength for older adults.
RESULTS : We developed a general mechanism to assess the frailty state of a group of elders by using mobile devices as supporting tools.
RESULTS : We developed an R package stpm for the SPM-methodology.
RESULTS : We developed a web-based database server , called Gerontome that contains aging-related gene information and user-friendly analysis pipelines.
RESULTS : We developed the Barcas program , a specialized program for the mapping and analysis of multiplexed barcode sequencing ( barcode-seq ) data.
RESULTS : We discovered @number@ miRNAs that discriminate AD from control CSF.
RESULTS : We employed biological and technical replicates and selected the intersection of the two results , which included @number@ proteins.
RESULTS : We employed several recruitment methods to identify and solicit @number@ female caregivers for participation in qualitative interviews and quantitative surveys.
RESULTS : We enrolled @number@ elderly participants : @number@ HS and @number@ comparison participants.
RESULTS : We enrolled @number@ of @number@ ( @percent@ ) subjects / proxies in the intervention group ; @number@ subjects served as controls.
RESULTS : We estimate that approximately @number@ million persons had symptomatic knee OA , with advanced OA comprising more than half of those cases.
RESULTS : We evaluated @number@ patients , @number@ males and @number@ females , with a mean age of @number@ ( 44-79 ) .
RESULTS : We evaluated @number@ studies encompassing @number@ patients in total , including @number@ who underwent operation with polymethylmethacrylateand @number@ who received non-operative treatments.
RESULTS : We examined @number@ patients , of which @number@ were octogenarians ( @number@ ± @number@ years ) .
RESULTS : We examined @number@ ( @percent@ ) participants.
RESULTS : We examined @number@ study participants with a mean follow-up of @number@ years.
RESULTS : We first demonstrated that S-nitrosylation of parkin decreased its activity as a repressor of p53 gene expression , leading to upregulation of p53.
RESULTS : We first examined whether mice and humans experience similar patterns of change in the methylome with age.
Results : We focused on carbamylated albumin because it corresponded to the size of the thickest band detected by western blotting of anti-CarP antibodies.
RESULTS : We followed up on @number@ patients with LONMO and @number@ with LONMOSD during a mean of @number@ years.
RESULTS : We found age-associated CpGs ( ageCGs ) that are both tissue-specific and common across tissues.
RESULTS : We found a length-dependent loss of ENFs that worsened with aging.
RESULTS : We found an association between hospital-wide nurse staffing levels and in-hospital mortality among patients with hip fractures.
RESULTS : We found an average intra-expert F1-score agreement of 72±7% ( κ : @number@.66±0.07 ) .
RESULTS : We found a positive association between head injury and PD risk.
RESULTS : We found a prevalence of hearing disorders in @number@ individuals ( @percent@ ) , of whom @percent@ used hearing aids.
RESULTS : We found a relationship between larger cerebellar volume and better global cognition , executive function , information processing speed , and motor speed.
RESULTS : We found a significant association between PA and the magnitude of P-E fit problems that explained @number@ % of the variance of PA.
RESULTS : We found a social gradient in AL in late midlife among men and women living in Denmark.
RESULTS : We found a strong EGFR expression on dysplastic and neoplastic FDCs.
RESULTS : We found differential associations for different negative life events with cognitive decline none of which were mediated by depressive symptoms.
RESULTS : We found evidence for an indirect relationship between sports club membership and frailty , mediated by physical activity.
RESULTS : We found five novel variations in @number@ patients and none of them presented in the @number@ controls.
RESULTS : We found five social network types.
RESULTS : We found gender differences and social class gradients for all physical performance tests.
RESULTS : We found higher all-cause mortality among many immigrant categories , although some groups had lower mortality.
RESULTS : We found improvement of general skill for the young adults in all delay conditions.
RESULTS : We found no association of early SH with any of the EEG measures.
RESULTS : We found @number@ articles , but @number@ were specifically focused on Si studies.
RESULTS : We found @number@ CpGs to be differentially methylated between the groups , including @number@ CpGs that overlap with clusters of differentially methylated probes.
RESULTS : We found @number@ distinct subgroups.
Results : We found @percent@ of adults aged @number@ years or older were frail.
RESULTS : We found @percent@ were legally married , and @percent@ unmarried partnered ; one-half were single.
RESULTS : We found positive hTERT in normal skin and in the basal and sometimes in supra-basal layers.
RESULTS : We found robust age-dependent changes in gene expression in the PFCs of humans ( @number@ transcripts ) .
RESULTS : We found significant changes in N-glycan composition in the sera of T2DM patients.
RESULTS : We found significant differences in genotypic and allelic frequencies between patients and controls.
RESULTS : We found significant effects of ageing on memory , grey and white matter measures.
RESULTS : We found statistically significant positive associations between BC and sICAM-1 for averages of @number@ @number@ and @number@ weeks.
RESULTS : We found that a decline in the total number of stressors was associated with a subsequent improvement on CERAD TS.
RESULTS : We found that attachment anxiety was highest among younger adults and lowest among middle-aged and older adults.
RESULTS : We found that average resorption pit area and percent resorption area decreased with increasing AGEs independently of age.
RESULTS : We found that Beut techniques @number@ through @number@ can be performed through @number@ midfacial viaducts.
RESULTS : We found that both antirodent Aβ antibody and siRNA against murine APP reduced LTP as well as contextual fear memory and reference memory.
RESULTS : We found that both PA and AF incidence clearly showed seasonal trends with an annual period and inverse correlation.
RESULTS : We found that , compared with no-feedback group , only social feedback substantially reduced the age-related deficit in prospective memory.
RESULTS : We found that low-grade inflammation is independently associated with total WBC , monocyte and neutrophil counts , but not geriatric conditions.
RESULTS : We found that memory ( Tcm and Tem ) CD8 T cells expressed a significantly higher level of ADRB2 compared to naïve cells.
RESULTS : We found that men had longer and wider LAAs.
RESULTS : We found that miR-22 was upregulated in aged EPCs.
RESULTS : We found that mRNA levels of most 5HT receptors were either very low or undetectable in MIN6 cells.
RESULTS : We found that old monkeys have greater systemic inflammation and poor intestinal barrier function as compared to young monkeys.
RESULTS : We found that @percent@ of the subjects were cognitively impaired.
RESULTS : We found that social desirability and acquiescence increased by between one and two standard deviations between adulthood and old age.
RESULTS : We found that the absolute number of tubal secretory cells increased significantly with age within each age group.
RESULTS : We found that the AD brain is capable of generating all macrophage-like responses.
RESULTS : We found that the average degree of age-related miRNAs was significantly higher than that of non age-related miRNAs in the miRNA-mRNA regulatory network.
RESULTS : We found that the expression of @number@ miRNAs in CCA tissues was significantly different from their corresponding adjacent normal bile duct tissues.
RESULTS : We found that the muscle moments generated by the extensor muscles decreased with age ( P < @number@ ) .
RESULTS : We found that the SC stiffens with age , indicating that the keratin fibers stiffen , similarly to collagen fibers in the dermis.
RESULTS : We found the highest [ ( @number@ ) C ] ABP688 BPND in the lateral prefrontal and anterior cingulate cortices.
RESULTS : We found the Katz-15 to be both internally consistent and strongly associated with quality of life measures.
RESULTS : We found these indicators to be significantly associated with many of the chemicals measured in maternal blood and urine.
RESULTS : We found three novel variations in @number@ patients.
RESULTS : We found UPR activation primarily in disease-affected brain regions in both disorders.
RESULTS : We generated @number@ responses for analysis.
RESULTS : We had @number@ aneurysms in the final series.
RESULTS : We have generated a comprehensive set of genome-scale base-resolution methylation maps from multiple mouse tissues spanning a wide range of ages.
RESULTS : We have noticed no systemic complications.
RESULTS : We identified aberrant phosphorylation of CDC25C-T48 in FLT3-ITD mutated cells.
RESULTS : We identified a CRC genetic risk score that independently predicted which patients in the training set would develop CRC.
RESULTS : We identified a homozygous c.655G > A mutation in the CARS2 gene cosegregating in the family.
RESULTS : We identified a large @number@ Mb duplication of the SNCA locus in this family.
RESULTS : We identified an approximately @number@.5-megabasepair duplication on chromosome 11q21-11q22.3 that segregates with disease.
RESULTS : We identified and replicated one significant gene-environment interaction between rs6933349 and smoking in DNA methylation of cg21325723.
RESULTS : We identified and reviewed @number@ suitable publications representing @number@ separate cohorts , of which @number@ had a term control group.
RESULTS : We identified CXCL10 as the most highly induced cytokine in JAK2-mutated cell lines.
RESULTS : We identified FA and 5-methyltetrahydrofolate ( 5-mTHF ) by retention time and characteristic response across the channels of the electrochemical detector.
RESULTS : We identified @number@ activity profiles : Low Activity , Moderate Activity , High Activity , Working , and Physically Active.
RESULTS : We identified @number@ articles ( n = @number@ ) published between @number@ and @number@
RESULTS : We identified @number@ DhMRs significantly associated with neuritic plaques and @number@ DhMRs associated with neurofibrillary tangles.
RESULTS : We identified @number@ high-confidence ageing-associated CpG sites , @percent@ of which were hypermethylated in nonagenarians.
RESULTS : We identified @number@ hospitals with @number@ ICU beds and @number@ mechanical ventilators for critically ill patients.
RESULTS : We identified @number@ incident cases of dementia ( @number@ with AD ) during follow-up.
RESULTS : We identified @number@ latent groups , and each group demonstrated distinct residual decline profiles.
RESULTS : we identified @number@ longitudinal cohort or repeated cross-sectional studies in the UK that involved older adults.
RESULTS : We identified @number@ miRNA gene candidates from bats , of which @number@ unique mature miRNA were obtained.
RESULTS : We identified @number@ new users of metformin and @number@ new users of sulfonylureas.
RESULTS : We identified @number@ novel genes that are essential for the delay in the onset of sarcopenia in daf-2 mutants.
RESULTS : We identified @number@ @number@ sepsis admissions occurring in @number@ @number@ individuals.
RESULTS : We identified @number@ observational studies and @number@ systematic review that generally showed a statistically significant relationship between pain severity and QoL.
RESULTS : We identified @number@ OTC NHP menopausal products , @number@ of which had Health Canada license numbers.
RESULTS : We identified @number@ patients who underwent a VHR ; @number@ ( @number@ % ) were ≥80 years of age.
RESULTS : We identified @number@ patients with a primary osteolysis syndrome who received @number@ anesthetics.
RESULTS : We identified @number@ prevalent cases and @number@ incident cases of PD during the follow-up.
RESULTS : We identified @number@ studies.
RESULTS : We identified @number@ studies published between @number@ and @number@ of which @number@ met inclusion criteria.
RESULTS : We identified @number@ subsequent hospitalizations for ischemic stroke and @number@ hospitalizations for hemorrhagic stroke within @number@ year after AMI.
RESULTS : We identified @number@ TOF patients ( prevalence @number@.63 / 1000 in pediatric patients and @number@.06 / 1000 in adult patients ) .
RESULTS : We identified several important differences in diagnostic criteria that may have contributed to the differing estimates of AD prevalence.
RESULTS : We identified the cut-off points of ASM / ht ( @number@ ) , gait speed and handgrip strength.
RESULTS : We identified two major factors and generated factor scores using factor analysis.
RESULTS : Weighted to the national population , @percent@ of CSHCN reported at least one unmet health service need in the previous year.
RESULTS : Weight gain was common among women ( @percent@ ) and men ( @percent@ ) .
Results : We included > 50000 persons with > 250000 person-years of follow-up.
RESULTS : We included all HHT patients in the County of Fyn , Denmark , prevalent as of @date@ in total @number@ HHT patients.
RESULTS : We included a total of @number@ patients , aged @number@ to @number@ years.
RESULTS : We included @number@ articles in our review.
RESULTS : We included @number@ children , of whom @number@ ( @percent@ ) were male and @number@ ( @percent@ ) were female.
RESULTS : We included @number@ demented patients with AD and @number@ age-gender-race-matched controls.
RESULTS : We included @number@ HCC patients from China and @number@ from the USA , and @number@ non-HCC patients in China and @number@ in China.
RESULTS : We included @number@ older persons who visited an emergency department because of a fall.
RESULTS : We included @number@ participants with mean age of @number@ ± @number@ years.
RESULTS : We included @number@ patients ( 86±6 years ) : @number@ DP , @number@ NDP , and @number@ CSND.
RESULTS : We included @number@ patients ( @number@ NOAC-ICH and @number@ VKA-ICH ) .
RESULTS : We included @number@ patients : @number@ patients in the manipulator group and @number@ patients in the no manipulator group.
RESULTS : We included @number@ patients of whom @number@ ( @percent@ ) used nonantiretroviral comedication.
RESULTS : We included @number@ patients , of whom @number@ were men.
RESULTS : We included @number@ patients ( @percent@ smokers ) and @number@ controls ( @percent@ smokers ) in our study.
RESULTS : We included @number@ siblings and @number@ controls in our study.
RESULTS : We included @number@ studies with a total of @number@ patients.
RESULTS : We included @number@ women in our analysis.
RESULTS : We initially identified @number@ articles , of which @number@ full-text articles were screened for inclusion.
RESULTS : We interviewed @number@ residents aged @number@ years and older.
RESULTS : We investigated , in the postoperative time , the role of alpha-tocopherol acetate compared to gomenol oil.
RESULTS : We now demonstrate that skeletal muscles isolated from these animals have differential levels of mutant full-length APP depending on muscle type.
RESULTS : We now directly test the hypothesis that cortical amyloid acts as an accelerant for spreading of tangles beyond the medial temporal lobe.
RESULTS : We numbered @number@ patients ( @percent@ of women , mean age @number@ years ) .
RESULTS : We observe a statistically significant temporal decline in inpatient acute days and a statistically significant increase in inpatient post-acute days following hip fractures.
RESULTS : We observed considerably impaired functioning for cases with stroke , TIA , PD , and mild motor parkinsonian signs ( MMPS ) .
RESULTS : We observed increased proportion of use of antihypertensive , from @percent@ in @number@ to @percent@ in @number@ reaching @percent@ in @number@
RESULTS : We observed no significant association between genetic variants and prostate cancer survival.
RESULTS : We observed no significant associations between lean mass and contractile properties when using single stimulation.
RESULTS : We observed no significant differences in cognitive performance between persons with or without PAD.
RESULTS : We observed @number@ cases of all-cause dementia over @number@ years of follow-up.
RESULTS : We observed @number@ eligible deaths , @number@ of whom had HIV.
RESULTS : We observed @number@ hepatic decompensation events in @number@ @number@ person-years of follow-up ( incidence rate , @number@.4 / 100 person-years ) .
RESULTS : We observed statistically significant improvement in exercise capacity ( from 423±94 to 496±13 m ; P < 0.05 ) .
RESULTS : We observed that exclusive breastfeeding up to @number@ month is rare.
RESULTS : We observed that increasing age was associated with higher VD grades ( P < @number@ ) .
RESULTS : We observed that lipoperoxidation measured by TBARS increased by age but no differences were observed by sex.
RESULTS : We observed that neither muscle development nor animal longevity was compromised in these transgenic animals.
RESULTS : We observed that the phosphoinositide 3-kinase / Akt pathway is activated by HBx in vivo and in vitro.
RESULTS : We obtained data from @number@ participants ( mean age , @number@ y ; @percent@ racial / ethnic minority ) .
RESULTS : We obtained two principal components : one that reflected the degree of urbanization and another that reflected the volume of pediatric service delivery.
RESULTS : We obtained valid data on greater than @percent@ of participants on each test.
RESULTS : We perform a comprehensive analysis of methylation profiles to narrow down @number@ age-related CpG sites in blood.
RESULTS : We present an open three-axial mono-hierarchical nomenclature called SNOCAP-HET.
RESULTS : We present the current evidence that associate mitochondrial dysfunction with age related decrease in female reproductive outcome.
Results : We propose the SNP Interaction Pattern Identifier ( SIPI ) , which tests @number@ biologically meaningful interaction patterns for a binary outcome.
Results were analysed using univariate and bivariate structural equation modelling.
Results were analyzed using multilevel analysis.
Results were applied to dietary data from @number@ participants in NHANES 2003-2004.
Results were back-weighted.
RESULTS : We received @number@ responses from the survey.
Results were combined in random-effects meta-analysis.
Results were combined using fixed-effect inverse-variance meta-analysis.
Results were combined with previous research to provide an evidence-based approach to assessing older cancer survivors.
Results were comparable across age , sex , and race , and in sub-groups based on diabetes mellitus or cardiovascular disease at baseline.
Results were comparable between the two cohorts.
Results were comparable in analyses that controlled for dementia or parkinsonism during the study or postmortem measures of plaques and tangles or nigral cell loss.
Results were compared between age groups and among MSC sources.
Results were compared between males and females , right and left ears and between age groups.
Results were compared to unbiased estimates derived from the Mantel-Byar model.
Results were compared using one-way analysis of variance ( alpha @number@ ) .
Results were compared with a group of younger women published previously.
Results were compared with field measurements taken in a smoker's home @number@ h after the last cigarette had been smoked.
Results were compared with two similar studies in Sweden and the USA.
Results were confirmed by sequencing PCR products and by using more specific primers ( LEW1 and TBR ) .
Results were confirmed in Monte Carlo simulations ( $ 3164 vs $ 3882 , savings of $ 718 ) .
Results were confirmed using an optical profilometry technique.
Results were consistent only with the regulatory-fit account.
Results were consistent with the hypothesis that racial disparities in cessation widen with increasing age.
Results were consistent with this prediction.
RESULTS : We recorded @number@ stroke patients.
Results were correlated with skin type ( Fitzpatrick ) and baseline photodamage ( Glogau ) .
RESULTS : We recruited @number@ cognitively normal controls , @number@ aMCI and @number@ AD patients.
RESULTS : We recruited @number@ consecutive participants , @number@ of whom were diagnosed with epilepsy by a study neurologist.
RESULTS : Were enrolled @number@ elderly in recreational group and @number@ in physical activity group.
Results were essentially similar before and after adjustment for key covariates.
Results were evaluated at one week , one month and three months after the final treatment.
Results were evaluated with ANOVA , Tukey , and Dunnett's T3 tests ( α = 0.05 ) .
Results were extended to the European early-onset dementia cohorts ( @number@ early-onset Alzheimer's disease [ EOAD ] patients and @number@ nonaffected individuals ) .
Results were first evaluated by dividing patients into @number@ age groups according to the generally approved cutoff value of @number@ years.
Results were found to be statistically significant.
Results were inconclusive for cognitive , functional , and social outcomes.
Results were materially unchanged when diabetics were excluded from the analysis.
Results were not mediated via current SES or health practices.
Results were presented as a narrative review because significant heterogeneity among included studies precluded a meta-analysis.
Results were presented as hazard ratios ( HRs ) with @percent@ confidence interval ( CI ) adjusted for age and sex.
Results were presented in narrative synthesis.
Results were qualitatively similar when change in the Geriatric Depression Scale score over time was used as the outcome instead of incident depressive symptoms.
Results were ranked into five categories ranging from @number@ to @number@
Results were regrouped according to cancer phase.
Results were significant.
Results were significant in fully adjusted models for those deteriorating from optimal to suboptimal vision levels.
Results were similar across age groups.
Results were similar after adjustment for depressive symptoms , social network size , social activity , and loneliness.
Results were similar between patients with or without adequate anti-osteoporosis drug treatment.
Results were similar but slightly attenuated using less stringent goals.
Results were similar for both outcomes.
Results were similar for combined disability and mortality.
Results were similar for FreeSurfer and tensor-based morphometry.
Results were similar for HMW adiponectin.
Results were similar for men and women.
Results were similar in models that included adjustment for hearing aid use.
Results were similar using an adjusted fixed ROI.
Results were similar when we further adjusted for temperature variability.
Results were similar when within-group comparisons were made before and after cross-over.
Results were similar whether bilingualism was measured via self-report or an objective test of reading level.
RESULTS were statistically evaluated at p < @number@ level of significance.
Results were summarized by using the best-evidence synthesis approach.
Results were summarized with a synthesis based on the best evidence.
Results were unchanged after co-varying for baseline mini-mental state exam and presence of vascular disease.
RESULTS : We review the molecular genetics of FOXO3 in longevity , then current knowledge of FoxO3 function relevant to ageing and lifespan.
Results were weaker for patella lead.
RESULTS : We screened @number@ citations and reviewed @number@ articles reporting @number@ RCTs with @number@ arms in @number@ @number@ participants.
RESULTS : We screened @number@ records and assessed eligibility of @number@ full-text articles.
RESULTS : We selected for analyses the items that corresponded to DSM-IV criteria and constructed a dichotomous variable.
RESULTS : We selected @number@ studies on CGA efficiency and @number@ on screening tools.
RESULTS : we selected seven articles for falls , none for delirium , two for cognition and two for end-of-life situations.
RESULTS : We showed that the network generating MMN consisted of @number@ nodes that could modulate all intra- and inter-nodal connections.
RESULTS : We show that expression of human ApoE4 renders aged mice fed with a western-type diet more susceptible to sensorimotor deficits upon stroke.
RESULTS : We studied @number@ elderly patients whose median age was @number@ ± @number@ years.
RESULTS : We studied @number@ HIV + and @number@ HIV- men.
RESULTS : We studied @number@ patient MR images , which included @number@ males ( @percent@ ) and @number@ females ( @percent@ ) .
RESULTS : We studied @number@ patients ( @number@ iECG , @number@ RC ) who were @number@.6±5.4 years of age ; @number@ were female.
RESULTS : We studied six cross-sectional RNA expression profiles from different human tissues.
RESULTS : We submitted the data obtained from the study to a statistical enquiry.
RESULTS : We successfully contacted and obtained follow-up data on @number@ patients ( @percent@ ) via email , telephone , and postal survey.
RESULTS : We successfully extracted and displayed data.
RESULTS : We suggested a novel computational approach to identify an integrative network which profiles an underlying genotypic signature from time-series gene expression data.
RESULTS : We validated our automated food residue removal technique against semimanual quantifications.
RESULTS : We verified that ERP data could yield features that discriminate the age group of individual subjects with high reliability.
RESULTS : When adjusting for age and gender , life span was not statistically different in persons with and without PES.
RESULTS : When carrying out repetitive moderate load operations , women aged over @number@ years exceeded the recommended energy expenditure ( @percent@ CI ) .
RESULTS : When compared to age- and gender-matched HIV-uninfected reference controls , older HIV-infected persons had diminished physical function.
RESULTS : When compared with cells from young adult donors , AOBs from elderly women exhibited lower maximal lifespan ( P < @number@ ) .
RESULTS : When comparing fibers of similar size , no effect of training or age was found for myonuclear domain.
RESULTS : When coresidence shifts occur , they are shaped by the needs of older adults.
RESULTS : When examining men and women separately , socioeconomic and behavioral risk factor mediators vary in their importance.
RESULTS : Whereas memory performance separated the AD group from the others , the performance of NC and subjects with aMCI was similar.
RESULTS : While CG did not show any statistically significant change of POMA at T1 and T2 , VG revealed significant differences.
RESULTS : While global BN topologies do not significantly change with age , local topologies of a number of genes do.
RESULTS : While PIB patterns were diffuse in both patient groups , ApoE4- patients showed higher PIB uptake than ApoE4 + patients across the cortex.
RESULTS : White women and men exemplify results.
RESULTS : Whole-body protein breakdown was activated during fasting in young and older individuals ( P < @number@ vs fasted state ) .
RESULTS : Whole-brain WMLL and amyloid deposition were significantly higher ( P < @number@ ) in MCI and AD patients compared with controls.
RESULTS : Widespread polypharmacy , giving rise to @time@ % of PIPs in the whole collection of prescriptions , was observed.
Results will address a significant gap in the current Australian community-support base for people living with dementia and their caregivers.
Results will also be informative to health systems outside VA aiming to reduce ED use through accountable care organizations.
Results will be disseminated at conferences , in peer-reviewed journals , on our websites and throughout the multinational Education Against Tobacco network.
Results will be disseminated via peer-reviewed journal articles and conferences.
Results will be published in scientific peer-reviewed journals , in PhD theses and at public meetings.
Results will guide the further development of an existing service robot , the Care-O-bot®.
RESULTS : With aging , CRRTs decreased in all directions on the hand , the forehead and the canthus.
RESULTS : With aging , the central fat pad volume appeared to diminish , with relative sparing of the nasal fat pad.
RESULTS : With aging , the least rise was seen in the lateral segment , which was not statistically significant.
RESULTS : With a median follow-up of @number@ years , locoregional recurrence rate was @percent@ ( nodal recurrence = 1.06% ) .
RESULTS : With a median follow-up period of @number@ years , none of the @number@ patients studied developed a chronic renal insufficiency.
RESULTS : With good recruitment rate ( @percent@ ) and compliance ( attrition @percent@ ; adherence @percent@ ) rates the intervention was deemed feasible.
RESULTS : With increasing postnatal age at examination , the high signal intensity on the T1WI for both STN and globus pallidus diminished.
RESULTS : Within CSA , pretreatment with MH and VL showed higher initial TBS compared with AM-treated groups.
RESULTS : Within each HIV / HCV group , the prevalence of advanced hepatic fibrosis increased as alcohol use category increased.
RESULTS : Within its first year of operation , the HABC delivered @number@ visits to serve @number@ patients and @number@ informal caregivers.
RESULTS : Within one year after hospital admission , @number@ ( @percent@ ) subjects were institutionalised.
RESULTS : Within the median @number@ years of follow-up , @number@ ( @percent@ ) deaths occurred.
RESULTS : With no interacting term , age was the most prominent predictor.
RESULTS : Without cues , PD participants had slower and less steady gait than HAM or young.
Results with respect to age revealed a decrease in reported executive function problems with increasing age.
RESULTS : WML was no longer related to cognitive performance after adding atrophy into regression equations.
RESULTS : Women included were @number@ aging 15-49 ( mean @number@ years ) , @percent@ were pregnant.
RESULTS : Women's experience of negative mood and depressive symptoms was highest during the menopausal transition and lowest in the late postmenopause.
RESULTS : Women showed higher prevalence rates of ADL , IADL , and PT compared to men.
RESULTS : Women showed variable plasma concentrations of several steroids associated with menstrual cycle phase , menopause and oral contraceptive use.
RESULTS : Women with greater rate of weight loss over @number@ years had increased chance of developing MCI or dementia.
RESULTS : Work demands were found to be moderate according to both HR data and TLX scores.
RESULTS : Workers had underlying medical conditions that affected surveillance results.
RESULTS : Working memory accuracy was reduced in dual-task contexts with either sensorimotor task and deteriorated further under triple-task conditions.
RESULTS : Working space was divided by right costal arch during right hemicolectomy for right sided colon cancer.
RESULTS : Workload measured by total new-to-doctor consultations increased @percent@ from @number@ to @number@ ( @percent@ annually , P = 0.0008 ) .
RESULTS : Workouts elicited the same heart rate response while random organization seems to elicit the highest lactate , C and T increases.
RESULTS : Worse pre-diagnosis HRQOL was significantly associated with greater risk of death across HRQOL measures.
RESULTS : Wrinkle severity decreased rapidly after treatment.
RESULTS : Wrinkle severity was greater at all assessed locations with older age.
RESULTS : Wrinkle widths below the eye in women ≥ @number@ years of age were significantly higher than in women 20-29 years of age.
RESULTS : WWC1 T carriers had significantly better delayed recall performance than CC individuals ( p = @number@ ) .
RESULTS : Young adults reported higher levels of health anxiety than older adults.
RESULTS : Young depressed women exhibited higher absolute mean SWA levels and a stronger response to sleep deprivation , particularly in frontal brain regions.
RESULTS : Younger ( < 55 ) and older ( ≥55 ) homeless veterans reported an equal number of days homeless before enrollment.
RESULTS : Younger adults showed greater overall levels of temporal and occipital cortical activation than older adults for both auditory and visual stimuli.
RESULTS : Younger and older adults held similar beliefs about the course of emotions across the life span.
RESULTS : Younger , more educated individuals chose the self-directed format ( P < @number@ P = @number@ respectively ) .
RESULTS : Young men were significantly ( p < 0.05 ) lighter and had less fat mass than older men.
RESULTS : Young's modulus , yield and elongation parameters showed no significant difference among samples.
RESULTS : Youths aging out of foster care are at high risk for becoming homeless during the transition to adulthood.
RESULTS : Zn ( 2 + ) generated a bell-shaped concentration response , both regarding deoxyribonucleic acid replication and protein synthesis in cultured BPH SMC.
RESULT : The content of the delusions was mixed including persecution , infidelity , and grandiosity.
RESULT : The first outcomes of facial lifting with barbed sutures remain inconclusive.
RESULT : The hematopoietic reconstruction cells of female recipient mice were derived from male donor mice.
RESULT : The knowledge and perception of HR among women of South East Nigeria is poor and related to the level of education.
RESULT : The number of EPCs ( @percent@ Vs.
RESULT : The prevalence rate of sleep disturbance varied between and within age groups , as well as between the @number@ European countries.
RESULT : The proportion of participants with undiagnosed depression was @percent@.
RESULT : The results showed that a rising trajectory of depressive symptoms came about for both Taiwan elderly male and female over ten years.
RESULT : There were no significant differences between the community and nursing home groups in any of the QOL domains.
RESULT : These studies evaluated @number@ cases and @number@ controls for MTHFR C677T.
RESULT : Twenty-four subjects completed the trial.
Resuscitated cardiac arrests ( @number@ vs. @percent@ ; p = @number@ ) were observed more often in this elderly patients during hospitalization.
Resveratrol acts on several molecular targets in adipocytes and osteoblasts leading to a decrease in adipocyte number and size and an increase in osteogenesis.
Resveratrol also possesses antioxidant , anti-coagulation and anti-aging properties , and it may control of cell cycle and apoptosis.
Resveratrol , an activator of class III histone deacetylase SIRT1 , is important in attenuating cellular injury and oxidative stress.
Resveratrol , a natural compound found in grapes , became very popular for its suggested protective effects against aging.
Resveratrol , a natural polyphenolic molecule with several biological activities , is a well recognized anti-oxidant , anti-aging and cancer chemopreventive agent.
Resveratrol and equol are two of the best-known polyphenolic or phytoestrogens having similar chemical structures and some overlapping biological functions to 17β-estradiol.
Resveratrol , a phytoalexin , has gained much attention recently due to its effects on sirtuins.
Resveratrol , a plant-derived polyphenol , regulates many cellular processes , including cell proliferation , aging and autophagy.
Resveratrol-dependent improvement of insulin-resistance occurred through inhibition of serine phosphorylation of IRS1 / 2 , implicating resveratrol as a serine kinase inhibitor.
Resveratrol , especially , has been shown to increase the antineoplastic activity of cisplatin.
Resveratrol functions as an agonist for estrogen receptor ( ER ) -mediated transcription.
Resveratrol has been shown to possess anticancer , anti-aging , anti-inflammatory , antimicrobial , and neuroprotective activities.
Resveratrol has been shown to reduce organ damage following traumatic and shock-like states.
Resveratrol has emerged as a leading candidate for improving healthspan through potentially slowing the aging process and preventing chronic diseases.
Resveratrol improves endothelial function in aging , at least in part , through inhibition of S6K1.
Resveratrol induced VSMC differentiation through stimulation of SirT1 and AMPK.
Resveratrol induces intracellular signal transduction pathways which ultimately lead to changes in the gene expression pattern of the cells.
Resveratrol is a botanical antioxidant with diverse biologic effects.
Resveratrol is a naturally occurring phenol that is generated by plant species following injury or attack by bacterial and fungal pathogens.
Resveratrol is a naturally occurring polyphenol that provides a number of anti-aging health benefits including improved metabolism , cardioprotection , and cancer prevention.
Resveratrol is a naturally occurring stilbene phytoalexin phenolic compound produced in response to a variety of biotic and abiotic stresses.
Resveratrol ( ) is a natural phytoalexin known for its cardioprotective , neuroprotective , anti-inflammatory , anti-cancer and anti-aging properties.
Resveratrol ( ) is a natural phytophenol.
Resveratrol is an effective anti-aging molecule with diverse biologic activity.
Resveratrol is a plant-derived polyphenol that exerts diverse antiaging activities , mimicking some of the molecular and functional effects of dietary restriction.
Resveratrol is a potent activator of Sirt1 which could modulate inflammation through deacetylating histones of transcription factors.
Resveratrol is a promising chemical agent that treats multiple aging-related diseases and improves life span.
Resveratrol is a putative SIRT1 activator that has been shown to delay neurodegenerative diseases , including Amyotrophic Lateral Sclerosis , Alzheimer , and Huntington's disease.
Resveratrol-mediated SIRT1 activation decreased the acetylation of p53 and p65 induced by prion protein and SIRT1 inhibitor.
Resveratrol pretreated MRC5 fibroblasts were resistant to activation by TGFβ.
Resveratrol ( RES ) is a natural antioxidant that protects against mitochondrial dysfunction in various cells.
Resveratrol ( RES ) is a plant polyphenol with various anti-aging properties.
Resveratrol ( RSV ) , a phytoalexin , has shown to prevent endothelial dysfunction and reduce diabetic vascular complications and the risk of cardiovascular diseases.
Resveratrol ( RSV ) is a natural polyphenol extensively studied for its potential health benefits.
Resveratrol ( RSV ) is one of those.
Resveratrol ( RSV ) is well known for its anti-oxidant and anti-aging properties.
Resveratrol ( RV ) is a polyphenolic compound naturally produced by plants.
Resveratrol ( RVT ) is a naturally occurring trihydroxy stilbene that displays a wide spectrum of physiological activity.
Resveratrol's effects on both senescence and proliferation disappeared when FOXO3 was knocked down.
Resveratrol suppressed melanogenesis by the downregulation of MITF and tyrosinase via ERK pathway.
Resveratrol treatment significantly increased both SIRT1 protein expression and SIRT1 activity and protected neuronal cells against PrP ( 106-126 ) -induced cell death.
Resveratrol was found to inhibit protein expression and enzyme activities of CYP17 and CYP21.
RESV mediates a wide-range of biological activities , which comprise an increased life span , anti-ischemic , anti-cancer , antiviral , anti-aging and anti-inflammatory properties.
Retained activity of BTK-T474 partially rescued cell migration from inhibition by dasatinib.
Retained articles were scored using an adapted version of QUADAS.
Retaining information over extended periods is critical , and there are reasons to expect age-related effects on the neural correlates of durable memories.
Retention and adherence were high ( > 90% ) .
Retention capacities were evaluated after @number@ h of wakefulness or @number@ h of sleep.
Retention interval increases deficit in persons with AD.
Retention loss of the restorations was evaluated after every @number@ thermocycles and every @number@ cycles of thermomechanical loading.
Retention of each memory component was tested , at multiple intervals , up to @number@ mo following encoding.
Retention rates and data variability were satisfying.
Retention tests were conducted on Day @number@
Retention values in the frontal cortex , precuneus , and anterior cingulate gyrus retention values inversely correlated with naming performance.
Retention was measured on a universal testing machine under tension , with a crosshead speed of @number@ mm / min.
Retention was tested @number@ weeks later.
Retention weighted scoring improved the discrimination of MCI and AD groups.
Retest agreement exceeded @number@ ( ICC2 , 1 ) for all tests , with no relevant differences observed between gender- and age-specific subgroups.
Retest correlations over time were very high for both manual and FreeSurfer segmentations.
Retesting these compounds at @number@ @number@ and @number@ μM using the same exposure protocol yielded consistent results as compared with the primary screen.
Retest reliability was @number@ for the unimpaired and @number@ for the impaired validation groups.
Retest reliability was unanimous in young and older persons.
Retests were performed in @number@ days.
Retina is particularly susceptible to aging as oxidative damage accumulates within retina , leading to age-related retinal dysfunction or even visual loss.
Retinal arteriolar caliber , retinal venular caliber and retinal vascular fractal dimension were not associated with ESRD.
Retinal diseases are a major cause of noncorrectable visual impairment and blindness in this older population.
Retinal diseases represented the major cause of noncorrectable visual impairment and accounted for more than half of causes of blindness.
Retinal ganglion cell ( RGC ) differentiation demonstrates increased cell death in LHON-RGCs and can be rescued in cybrid corrected RGCs.
Retinal grading was performed in a masked fashion using a modified version of the International Classification and Grading System for AMD.
Retinal microvasculature can now be visualized , quantified and monitored non-invasively using state-of-the-art retinal imaging technology.
Retinal morphology was studied with fundus imaging , histology , light microscopy , electron microscopy , and immunohistochemistry.
Retinal neurodegenerative diseases like age-related macular degeneration , glaucoma , diabetic retinopathy and retinitis pigmentosa each have a different etiology and pathogenesis.
Retinal neurons and glia are generated in a conserved order from a pool of mutlipotent progenitor cells.
Retinal photographs were obtained in @number@ of these participants.
Retinal pigment epithelial cells as well as choroidal melanocytes ( CM ) possess melanin granules.
Retinal pigment epithelial ( RPE ) cells are continually exposed to oxidative stress that contributes to protein misfolding , aggregation and functional abnormalities during aging.
Retinal pigment epithelium cell density peaks at the fovea , independent of age , yet no net RPE cell loss is detectable.
Retinal pigment epithelium cells incubated with A2E displayed fluorescent bodies within the cytoplasm.
Retinal pigment epithelium cytoskeleton was labeled with AlexaFluor647-Phalloidin.
Retinal structure was associated with MTL volumes , but not memory performances , in otherwise neurologically normal older adults.
Retinal structure was not significantly associated with verbal or visual memory consolidation performances ( ps > @number@ ) .
Retinal thickness ( RT ) and fovea pit profile slopes were measured using optical coherence tomography ( OCT ) .
Retinal vascular Df was calculated with monofractal and multifractal analysis , performed on custom-written software.
Retinal vein images at the AV crossing were obtained by optical coherence tomography.
Retinal vessel measurement using Dynamic Vessel Analyzer consisted of 50-seconds baseline acquisition , followed by three 20-second flicker and 80-second relaxation periods.
Retinal vessels become hyalinized and there is a loss of rods before cones in the macula.
Retina-preserving activity of the collected CM was evaluated using an in vitro model of degenerating porcine retina.
Retina-preserving activity of the collected CM was evaluated using degenerating porcine retina in vitro.
Retinoic acid in different formulations has emerged as an alternative to prevent and repair age-related skin damage.
Retinoic acid is the major physiologically active metabolite of retinol regulating gene expression through retinoic acid receptor - dependant and independent pathways.
Retinoic acid ( RA ) is gold standard treatment for photoaging.
Retinoic acid ( RA ) signalling has a central role during vertebrate development.
Retinoic acid receptor-related orphan receptor α ( RORα ) is a nuclear receptor and can regulate several lipid metabolism genes in certain cancers.
Retinoids are essential in the development and function of several organ systems ; however , deregulated retinoid signaling can contribute to serious diseases.
Retinol and riboflavin deficiency has been detected in a small proportion of children of all ages.
Retinol is a pivotal regulator of differentiation and growth of developing as well as adult skin.
Retinopathy was graded using the modified Airlie House classification system.
Retinyl palmitate ( RP ) is widely used in pharmaceutical and cosmetics products to improve the skin elasticity.
Retirees were still not more depressed but less active.
Retirement behavior is examined by means of event-history models , with a competing risks framework being used to distinguish between voluntary and involuntary work-exit transitions.
Retirement pension had negative relationship with work after retirement.
Retirement policies or strategies for maintaining and promoting favorable SES in early old age may benefit the health of elderly adults later in life.
Retirement village managers ( n = @number@ ) were surveyed on village descriptive characteristics , including the provision of amenities and facilities.
Retrieval-induced forgetting ( RIF ) is a phenomenon wherein practicing recalling some items impairs recall of semantically related , unpracticed items.
Retrieval of verbal memory is a good surrogate measure reflecting frontal lobe functioning.
Retrobulbar fat showed significant age-associated increases in T1 values in the lateral side and in T2 values in both sides.
Retrogenesis refers to the phenomenon by which degenerative processes in aging reverse the sequence of acquisition in development.
Retrograde axonal transport also plays a major role in neurotrophic and injury response signaling.
Retrograde backflow , however , was greater with a cannula ( @percent@ ) compared to a needle ( @percent@ ) .
Retrograde transport is required to maintain homeostasis by removing aging proteins and organelles from the distal axon for degradation and recycling of components.
Retrograde transpubic screw fixation is recommended for pubic rami fractures.
Retropubic suspension and artificial urinary sphincter are also treatment options in appropriately selected patients.
Retrospective 25 ( OH ) D standardization can be applied to old studies where stored serum samples exist.
Retrospective analysis of clinical records of the patient revealed surgical removal of a meningocele present at birth.
Retrospective analysis was performed for @number@ patients who had experienced MI between @number@ and @number@
Retrospective and observational data were collected from direct professional and personal contact with the @number@ men in the running club.
Retrospective and prospective epidemiologic studies suggest that enhanced coffee / caffeine intake during aging reduces risk of Alzheimer's disease ( AD ) .
Retrospective and prospective observational studies were included.
Retrospective clinical and EEG data were retrieved from hospital archives or family documents.
Retrospective data were available from @number@ healthy controls and @number@ HD participants with CAG repeats ≥40 , and a total of about @number@ visits.
Retrospective information indicated that most participants used complementary therapies ( e.g. , @percent@ used home remedies in the past year ) .
Retrospective in nature , @number@ inpatient cases were compared.
Retrospectively registered @date@ .
Retrospectively registered on @date@ .
Retrospectively registered on @date@ .
Retrospectively , we examined the role of explicit , intentional retrieval strategies in priming.
Retrospective memory contributed small but significant unique variance ( β = @number@ ) to PM accuracy.
Retrospective self-recorded data on recent weights and every decade since the age of @number@ as well as the decade prior to diagnosis were collected.
Retrospective self-report might be the only possibility to capture prior weight.
Retrospective studies and those relying on identification by the usual treating team reported lower prevalence rates.
Retrospective studies of prescription databases have produced controversial and conflicting results.
Retrotransposons account for almost half of our genome.
Return migrant women are more likely to be disabled while men are wealthier than comparable older adults in Mexico.
Revanesse® Ultra ( Prollenium ) , a HA dermal filler , was used.
Revascularization decreases the rate of amputation.
Revealing differences in how MSCs are affected by age could help identify an optimal cell source for musculoskeletal therapies targeting older patients.
Reveals that the decision-making process is often reported as an interrelated experience by the couples and as a dyadic stressor.
Reverberation , however , reduces the reliability of the cues that allow a target source to be segregated and selected from a sound mixture.
Reversal of functional hypothalamic amenorrhea includes restoration of ovulatory ovarian function and fertility and amelioration of hypercortisolism and hypothyroidism.
Reverse mentoring focuses on knowledge sharing and leadership development.
Reverse total shoulder arthroplasty is a newer option that appears to be less dependent on tuberosity healing than hemiarthroplasty.
Reverse transcription polymerase chain reaction ( RT-PCR ) was used to assess AR gene expression.
Reversible cognitive impairment is indicated by subjective cognitive decline ( SCD ) and / or positive fluid and imaging biomarkers of amyloid-β accumulation and neurodegeneration.
Reversible infantile respiratory chain deficiency is characterised by spontaneous recovery of mitochondrial myopathy in infants.
Reversible posttranslational modifications are emerging as critical regulators of mitochondrial proteins and metabolism.
Review by a cardiologist is often useful to exclude myocardial ischaemia and to perform echocardiography which is a key investigation in assessment of CHF patients.
Reviewed species were primarily wild or wild cultivated , native to subtropical and temperate forests , and pend IUCN Red List of Threatened Species assessment.
REVIEWERS : This article was reviewed by Luigi Bubacco , Patrick Lewis and Xavier Roucou.
REVIEW METHODS : A review matrix was created to abstract information from @number@ studies so that synthesis could occur.
REVIEW METHODS : Two authors independently assessed trial eligibility , extracted data and assessed methodological quality.
Review of medical records contained detailed seizure description.
Review of the literature provides a starting point for physicians seeking to treat patients safely and effectively with newer devices.
Review of the literature supports the use of NAFL and AFL as safe and effective treatments for photoaging.
Reviews of national plans and reports on dementia show minimal consideration of ID and the challenges that carers face.
Reviews of rhGH in the somatopause have not been overtly favorable.
Review studies so far have presented important discrepancies , thus perpetuating a lack of clarity regarding this important geriatric care problem.
Review studies were excluded , as well as MSc dissertations , PhD theses and research with convenience sampling.
Revision surgery was performed in @number@ patients ( @percent@ ) , most of whom had long construction.
Revision surgery was performed in @number@ percent , mainly for incomplete correction of asymmetry ( @number@ percent ) or ptosis ( @number@ percent ) .
Revisions were made to the MAT based on recommendations from sites.
Rev. , @number@ 699-720 ) .
Reward seeking behavior undergoes tremendous changes in adolescence paralleled by neurobiological changes of this network including the prefrontal cortex , striatum and amygdala.
Rey's Auditory Verbal Learning Test ( AVLT ) is widely used to evaluate dysfunctional episodic memory.
Rey's Dot Counting Test ( DCT ) ( times criterion ) achieved @percent@ specificity , and was the only test passed by every participant.
REZULTS : Patient age was @number@ to @number@ years.
RFB-IAP alone , compared to doing nothing , prevents @percent@ of infant GBS cases at a cost of $ 240 / DALY.
RFB-IAP is also very cost-effective , but prevents only @percent@ of cases.
RF can be delivered using monopolar , bipolar , and unipolar devices , and each method has theoretical limits of depth penetration.
RF heating occurs irrespective of chromophore or skin type and is not dependent on selective photothermolysis.
RF thermal stimulation is believed to result in a microinflammatory process that promotes new collagen.
RF was carried out at a temperature higher than 40°C on the epidermis for @number@ min.
Rg1 ' s anti-aging effect is superior to its effect of treating aging.
RGN has been shown to have antioxidant properties by its activity reducing the production of reactive oxygen species and increasing the antioxidant defenses.
RhCMV shedding was measured by real time PCR in plasma , saliva and urine.
Rhes robustly binds the autophagy regulator Beclin-1 , decreasing its inhibitory interaction with Bcl-2 independent of JNK-1 signaling.
Rhesus macaques have been widely used for medical research including drug testing , neurology , behavioral and cognitive science , reproduction , xenotransplantation and genetics.
Rhesus monkey ( Macaca mulatta ) is the most extensively studied diurnal nonhuman primate.
Rhesus monkeys ( Macaca mulatta ) are excellent models for human cognitive aging and may provide novel insights on this issue.
Rheumatoid arthritis ( RA ) affects mainly women during their childbearing years.
Rheumatoid arthritis ( RA ) is associated with increased vascular calcification , although the rate of progress of calcification is uncertain.
Rheumatoid synovial tissues can be viewed as a tumor-like mass , consisting of hyperplastic fibroblast-like synoviocytes ( FLSs ) .
Rhinosinusitis is a common disease that affects more than @number@ million people in the USA every year.
Rhodiola rosea , growing in high altitude or cold regions of the world , has been reported to have anti-aging effects in Drosophila.
RhoGDIα is a key regulator of Rho proteins , coordinating their GTP / GDP and membrane / cytosol cycle.
Rho-GTPases undergo prenylation by attachment of ( GGPP ) catalyzed by GGTase-I.
Rho signaling regulates a variety of biological processes , but whether it is implicated in aging remains an open question.
RHR is independently associated with longevity even when familial factors are controlled for in a twin design.
RHR was assessed by palpating radial pulse.
RHTN patients were identified as controlled ( CRH , n = 43 ) or uncontrolled ( UCRH , n = 47 ) .
Rhythm-centred music making ( RMM ) has been shown to improve physical , psychological and social health.
Rhythmic genes were confirmed by quantitative reverse transcription-polymerase chain reaction using mouse tissue , primary chondrocytes , and a human chondrocyte cell line.
Rhythm is a temporal gait aspect that includes cadence and reflects how quickly steps are taken.
Rhytidectomy alone often fails to achieve a patient's expected goals , which is why there is a high demand for adjunct laser skin treatment.
Rhytidectomy surgeons should incorporate nonsurgical techniques into their practice to best serve the needs of the modern aging face patient.
Ribavirin-induced anemia , however , remains poorly understood and precludes rational optimization of combination therapy.
RIBE manifests itself by intercellular communication from irradiated cells to non-irradiated cells which may cause DNA damage and eventual death in these bystander cells.
Riboflavin deserves more attention for slowing human aging.
Ribosomal biogenesis and the mitochondrial DNA content were significantly reduced in these mice , along with a decrease of oxidative stress.
Ribosylation generated very high levels of PEN ( approx.
Richard Wallaschek seems to have been the only one from the late-nineteenth century to synthesize ideas from musicology , psychology , and neurology.
Rifampin can still be used in most patients who recover from AKI.
Right atrial cardiomyocytes were analyzed for mitochondrial function , markers of apoptosis , cardiac load or metabolism , and oxidative stress parameters.
Right brain damaged patients did not modulate the magnitude of the spatial priming effect with variation in repeat frequency , as did the control groups.
Right brain damaged patients with left spatial neglect typically bisect long horizontal lines to the right of their midpoint.
Right eye movements were recorded with an EyeLink @number@ infrared camera system.
Right hemisphere impairment coupled to a left hemispheric compensation might explain the perceptual shift observed in older adults.
Right hemisphere was still more complex in men.
Right kidney and liver weights of dosed males and females were generally significantly greater than those of the vehicle controls.
Right / left averages for levels L2 through L5 were determined.
Right-left regional cerebral differences are a feature of the human brain linked to functional abilities , aging , and neurodevelopmental and mental disorders.
Right thoracic curvature has also been reported in the normal spine.
Right thoracic curvature was given a positive value.
Rigorous evidence on the amounts , intensities , and movement patterns associated with better health in later life is needed.
Rigorous trials investigating the effects of protein supplementation on physical performance in sarcopenic populations are still scarce.
RIPK1 has important kinase-dependent and scaffolding functions that inhibit or trigger necroptosis and apoptosis.
RIP pull-down and luciferase reporter assay were used to verified the combination and regulating among TUG1 , miR-421 and caspase-3.
Risedronate itself strongly decreased bone resorption.
Rising obesity rates , coupled with population aging , have elicited serious concern over the impact of obesity on disability in later life.
Risk algorithms at baseline ( 1997-1999 ) were the Framingham Offspring , Cambridge , and Finnish diabetes risk scores.
Risk assessment of cardiovascular diseases ( CVD ) is shifting from the relative risk to an absolute risk approach.
Risk aversion and temporal discounting are preferences that are strongly linked to sub-optimal financial and health decision making ability.
Risk estimates calculated for HIV + and uninfected groups separately were not significantly different.
Risk estimates for deaths due to cancer , dementia , and ischemic stroke were not significant.
Risk estimates with the use of high body mass index were similar to those of MetS phenotypes in predicting adult outcomes.
Risk-factor assessment was conducted on initial encounter.
Risk factor-based IAP ( RFB-IAP ) for women with risk factors at delivery has had limited success in preventing neonatal infection.
Risk factor management is complicated by polypharmacy-related adverse events.
Risk factors , anthropometry and bone mineral density were recorded and considered in the reply and recommendations to the referring doctor.
Risk factors associated with AAA were to current and former smoking , age , and presence of femoral murmur.
Risk factors for breast cancer include early menarche , late menopause , hormonal therapies , exposure to environmental pollutants , smoking and alcohol use.
Risk factors for cardiovascular diseases ( CVDs ) and diabetes overlap , leading to the hypothesis that both share an inflammatory basis.
Risk factors for CSTF included booster injections ( @number@ patients ) and increased immune system reagibility ( @number@ patient ) .
Risk factors for incident microbleeds were similar to those for prevalent microbleeds and differed according to microbleed location.
Risk factors for infection were identified from the patient medical record.
Risk factors for MRSA carriage were identified by multiple logistic regression analysis.
Risk factors for osteoporosis appear to have increased through time.
Risk factors for POCD are aging , extensive invasive operations , intra and postoperative complications , and anesthetics.
Risk factors for poor survival included decreased or decreasing serum albumin levels , increasing age or over @number@ years and male gender.
Risk factors for postoperative falls among older hip fracture patients in Taiwan remain to be confirmed.
Risk factors for prognosis , such as 28-day mortality were analyzed using logistic regression analysis.
Risk factors for PrUs remain unclear in a community population.
Risk factors for refeeding syndrome did not predict falls in serum phosphate or magnesium.
Risk factors for sarcopenia include age , malnutrition , and physical inactivity.
Risk factors for such cognitive decline are unknown.
Risk factors for the occurrence of surgical site infections include variables related to the surgical procedure as well as host factors.
Risk factors for traditional serrated adenomas are largely unknown.
Risk factors , functional abnormalities along with symptoms affecting quality of life , were assessed by means of disease specific questionnaire.
Risk factors ( gender age , contact animal and breed dog ) were not significant ( P > 0.05 ) .
Risk factors include age and specific immunosuppression regimens.
Risk factors include an aging transplant population , oncogenic viruses and the long term effects of immunosuppression in the development of carcinogenesis.
Risk factors including obesity , medications , hereditary factors , and diet are critically reviewed with the most up-to-date evidence.
Risk factors measurements included waist circumference , body mass index , lipids , glucose , C-reactive protein , smoking and family history of coronary disease.
Risk factors , such as risk-taking behaviour , smoking and hypertension , are prevalent and amenable to early interventions.
Risk factors that predict an increased risk of falling are described.
Risk factors with moderate and consistent associations were higher body mass index , history of cardiovascular disease , hypertension , and higher plasma fibrinogen.
Risk for delayed AD diagnosis in the aging HIV-infected population is now among the most pressing issues in geriatric neuroHIV.
Risk for second kidney cancer was also increased , particularly after endometrial cancer of clear cell histology.
Risk for the recipient , however , must continually be evaluated and frequently updated in the context of that for the donor.
Risk for weight gain was higher among those with greater disease severity , regardless of weight at initiation.
Risk identification could assist in assessment of suicidality in this group.
Risk model prediction and validation were examined with the C statistic , net reclassification improvement , and integrated discrimination improvement.
Risk models were represented as risk score diagrams by gender for the age intervals 2-4 y and 2-6 y.
Risk of any end point ( complication or death ) became significantly higher at A1C ≥8.0%.
Risk of atrioventricular block requiring a pacemaker was @percent@.
Risk of bias and the quality of evidence was assessed using established methodologies.
Risk of bias was assessed for animal and human studies.
Risk of bias was assessed using the QUADAS-2 checklist.
Risk of CVD mortality was significantly greater in sarcopenic and obese but not sarcopenic obese men.
Risk of death ( alone ) was associated with age ( RR , @number@ @percent@ CI , @number@.54-1.84 ) .
Risk of disease is dynamic and changes in response to complex interactions of genetic , environmental and stochastic factors over the lifespan.
Risk of hemorrhage was affected significantly by eGFR-INR interaction.
Risk of menopause entry in CYP3A4 wild types who smoked was far lower ( adjusted HR , @number@ @percent@ CI , @number@ @date@ ) .
Risk of mental health problems was identified by hospice providers postloss.
Risk of mortality was calculated using a competing risk model.
Risk of OP-fractures was analyzed using Cox regression.
Risk of PIDP was positively associated with the total number of drugs and diseases , but negatively with age.
Risk of TKR over @number@ months was @percent@ , @percent@ , and @percent@ for knees with no , inconsistent , and consistent FKP , respectively.
Risk of traffic accident was greater in employed men ( @number@ @number@.40-2.22 ) and women diagnosis with arthritis ( @number@ @number@ @date@ ) .
Risk periods prior to antipsychotic initiation were also included to search for evidence of confounding by indication.
Risk-prediction scores were similar between those with ' known ' ( documented ) and occult ( only on ECG ) AF.
Risk preference also modulated striatal responses during feedback with risk-takers showing more positive responses to gains compared with risk-averters.
Risk ratios and the relative excessive risk due to interaction and @percent@ confidence intervals were modeled for separate and joint prediction estimates , respectively.
Risks are presented as odds ratios ( OR ) with @percent@ confidence intervals ( CI ) .
Risks by genotype also did not vary by smoking or by family history of prostate cancer.
Risk scores and C-statistics were computed for individual participants for the ANU-ADRI and the CAIDE index.
Risk scores can help to identify high-risk individuals who might benefit from different interventions.
Risk scores may have utility for frailty prediction in clinical practice.
Risk scores were calculated by dividing the individual regression coefficients by the regression coefficient with the lowest β to create simple scores.
Risks of initial hemorrhage were history of hypertension , smaller AVM size ( < 3 cm ) and exclusively deep venous drainage.
Risk stratification models are effective tools for the management of cardiovascular diseases.
Risks were assessed by Cox proportional hazards.
Risk taking increases dramatically after the onset of puberty , contributing to a @percent@ increase in mortality.
Risk tended to be higher in patients with either near-normal glycemia or very poor glycemic control.
Risk was higher in individuals with a lower eGFR , hypertension , and a higher body mass index.
Risk was particularly low after screening colonoscopy , even for cancer in the right colon.
RK in the presence of ATRA increased alkaline phosphatase ( ALP ) activity in a dose-dependent manner.
RK in the presence of rhBMP-2 also increased ALP activity.
RK promoted the differentiation of C3H10T1 / 2 stem cells into osteoblasts.
RL decreased discretely with ageing but without an obvious statistical correlation.
RLG presented better results than CG on follow-up ( p = @number@ ES = @number@ ) .
RLPFC has shown functional and structural changes with age , with increasing specificity of left RLPFC activation for relational integration during development.
RL showed discrete decreasing trend with ageing but without an obvious statistical correlation.
RL tended to increase protein components of the 40S ribosomal subunit in Y only ( ≈ + 20-25% ; P ≤ @number@ ) .
RM boosted the production of enzymes responsible for the breakdown of glycogen and lipid droplets.
RMDs are applied to > 1 patient , and users reprocess them prior to repeat use.
RMI1 attaches to the edge of the gate in TopIIIα through which DNA passes.
RMI1 projects a 23-residue loop into the TopIIIα gate , thereby influencing the dynamics of its opening and closing.
RM impairments in aMCI likely reflect neural changes in the medial temporal lobe ( MTL ) and posterior parietal cortex ( PPC ) .
RMR was measured using indirect calorimetry and the thermic effect of meals was estimated at @percent@ of TEE.
RMSD , on the other hand , decreased monotonically.
RNA and DNA were isolated from @number@ bone biopsies of postmenopausal donors varying markedly in bone mineral density ( BMD ) .
RNA-binding proteins ( RBPs ) are involved in mRNA splicing , maturation , transport , translation , storage and turnover.
RNA editing is a complex process affecting the mechanism of changes in transcriptome sequences.
RNA expression was analyzed using an analysis of covariance.
RNA from iliac crest bone biopsies were analyzed by Affymetrix microarrays and real-time reverse-transcriptase polymerase chain reaction ( RT-PCR ) .
RNAi analysis showed that OSG-1 was specific toward activation of RHO-1 GTPase signaling.
RNAi experiments using siRNA against TAK1 and p38 pathways blocked the phosphorylation of serine residue.
RNAi further implicated actin-binding proteins ARX-3 and ARX-5 , thus the actin cytoskeleton , as one of the targets of OSG-1 / RHO-1 signaling.
RNAi-mediated knockdown of RAB6A / A ' prevents the localization of COH1 to the Golgi complex.
RNA interference-mediated depletion of endogenous NICD and HIF-1α also decreased cell death under ischemia-like conditions.
RNA molecules are often altered post-transcriptionally by the covalent modification of their nucleotides.
RNA polymerase III ( Pol III ) synthesizes tRNAs and other small noncoding RNAs to regulate protein synthesis.
RNA ( RIP-seq ) identified ribosomal RNA ( rRNA ) as the predominant RNA binding partner of SIRT7.
RNA samples were extracted from @number@ cell line mixtures expressing various BCR-ABL1 transcript levels.
RNAseq analysis confirmed that many of these loci are expressed.
RNA-Seq analysis yielded @number@ differentially expressed transcripts ( corrected p-value ≤ @number@ ) , predominantly associated with mitochondrial genes and noncoding RNA.
RNA-seq identified many more differentially expressed transcripts enriched in immune system processes.
RNA sequence libraries were prepared following ribosomal RNA depletion , and sequencing was undertaken by using the Illumina HiSeq @number@ platform.
RNA sequencing analysis of testes revealed significant alterations in the non-coding regions of mutant mouse genome.
RNA sequencing in human islets revealed GPRC5C expression correlated with the expression of genes controlling apoptosis , cell survival and proliferation.
RNA was extracted and converted to cDNA.
RNA was extracted from each skin sample , followed by cDNA synthesis and RNA-seq.
RNA was extracted from muscle.
RNFL thicknesses were measured with RTVue-100 OCT.
RNFL thickness was measured by iVue SD-OCT.
RNFLT was furthermore linked to the disease duration ( p < 0.001 , GEE ) but neither to disease severity nor patients ' age.
RNs in ambulatory practice must expand their role to assist primary care physicians meet the growing demands of the aging American population.
R ( @number@ ) = 0.381 , p < 0.001 ) with sex significantly influencing this correlation ( p < 0.001 , adj.
R ( @number@ ) = 0.563 , p < 0.001 ) with sex having a significant ( p = 0.005 , adj.
R ( @number@ ) = 0.592 ) and side no influence on the correlation.
R ( @number@ ) = 0.598 ) .
R ( @number@ ) of logistic regression equation was used to estimate the goodness-of-fit of vascular diseases logistic regression models.
Road traffic noise was weakly positively associated with the incidence of self-reported hypertension.
Roberts syndrome is the next most common cohesinopathy.
Robot-assisted surgery has gained a lot of space in the last decade , but it still needs to dodge the trade barrier.
Robot-assisted surgery is a recent improvement of conventional minimally invasive surgery.
Robotic guidance data included execution rate , accuracy of guidance , total surgical time , and time required for robotic guidance.
Robotics technologies are expected as one of the effective methods to solve the problem in terms of detecting malfunction in swallowing and recovering swallowing function.
Robots could potentially facilitate healthy aging by engaging older adults in partner dance-based exercise.
Robust age differences in switch costs were observed across RSIs suggesting that task reconfiguration processes are different following endogenous than exogenous task selection.
Robust differences were found with several tasks of a neuropsychological screening battery.
Robust engraftment and intricate functionality of transplanted hBMEPCs likely abrogated stroke-altered vasculature.
Robust evidence across cohort studies , using standardised measures within a clear conceptual framework , will benefit policy and practice to promote healthy ageing.
Robust linear associations were observed between testosterone and perceived stress ( r range : @number@ to @number@ ) ; concentration-dependent patterns were less discernible.
Robustness across different scanners was validated using ten subjects from ADNI2 / GO study.
Robustness analysis revealed small changes related to parameter choices for histogram processing.
Robust RCTs examining WBV-only exposure on balance and functional mobility in older adults are warranted.
Robust scientific evidence demonstrates that senes-cence induction in cancer works as a potent weapon to eradicate tumorigenesis.
ROCK2 inhibition upregulated M1 markers without affecting macrophage recruitment , underlining the plasticity of these macrophages.
ROCK activation phosphorylated Rac1b at Ser71 and increased ROS levels by facilitating the interaction between Rac1b and cytochrome c.
ROCK inhibitors may be a new pharmacological approach to modulate human bladder hyperactivity.
ROCK isoforms determine macrophage polarization into M1 and M2 subtypes.
Rodent and clinical studies suggest that OSA impairs the structural integrity of several brain regions , including the medial temporal lobe.
Rodent models of Huntington disease ( HD ) are valuable tools for investigating HD pathophysiology and evaluating new therapeutic approaches.
Rodent , porcine / bovine and human RPE cells recognize POS from various species in a similar manner.
Rodents are conventional models for studying postmenopausal osteoporosis , but the major limitation is that ovariectomy is needed to mimic the estrogen decline after menopause.
Rodents are often the species of choice to examine the effect of drugs on survival and on the progression of specific diseased tissues.
Rodents are the most commonly used model organisms in studies of aging in vertebrates.
Rodents frequently exhibit rotational bias associated with asymmetry in lesions and neurotransmitters in the striatum.
Rodents models have often been used to enhance our understanding of mechanisms of age-related changes in human skeletal muscle.
Rodents , specifically rats , are the primary animal models used in toxicology testing.
Rods are selectively impaired in aging and many disorders of the retina , notably Age-Related Macular Degeneration ( AMD ) .
Role dissonance is an uncomfortable experience for graduate paramedics , and some blame their university education for the problem.
Role models were gender matched.
Role of developmental exposure to environmental agents in altering the disease process is well known.
Roles in development , sexual differentiation , and long-term neuronal survival have been suggested.
Romania has entered a period of rapid and dramatic population aging.
Romidepsin ( FK228 , depsipeptide ) is a potent HDAC inhibitor.
Ron J. van Golde has received unrestricted research grants from Ferring and Merck Serono , outside the submitted work.
Root-ADJCI was lower with greater adherence to recommendations for vegetables and total grains and greater with greater sugar-sweetened carbonated beverage consumption.
Root caries incidence rate did not vary significantly between quartiles.
Root-cause analyses were performed for all @number@ acute transfers of these long stay residents.
Root mean square error also increased on the low-friction surface for all subjects.
Root mean square error was calculated to quantify performance.
Root transparency has proven to be related to age and has been considered by different odontological methods for age estimation.
ROR1 and ROR2 are inversely expressed in melanomas and negatively regulate each other.
RORα and CS also inhibited the migration of A7r5 cells in two-dimensional and three-dimensional cell migration assays.
RORγt ( + ) CD34 ( + ) HPCs were located in tonsils and intestinal lamina propria ( LP ) and selectively differentiated toward ILC3s.
( Rosaceae ) is a traditional medicinal plant in P. R. China.
ROS also serve as a trigger switch for signaling cascades leading to corresponding cellular and molecular events.
ROS alter signaling pathways and constitute potential therapeutic targets to limit oxidative damaging effects in aging-associated diseases.
Rosario Hernandez was one of the first investigators to recognize the implications of this unique circumstance.
ROS can activate upstream kinases ( MKK ) responsible for MAPK activation and restrict the activity of their inhibitory phosphatases.
ROS can also lead to lipid peroxidation , whose byproducts can also react with DNA to produce exocyclic DNA lesions.
ROS can cause oxidation in both amino acid side chains and protein backbones , resulting in protein fragmentation or protein-protein cross-linkages.
ROS concentrations between 50-565 nmol m ( @number@ ) were detected in fresh SOA and SHS samples.
Rose bengal , a singlet oxygen producer structurally unrelated to verteporfin , also produced crosslinked p62 oligomers and inhibited autophagosome formation.
Rosen RC , Wu F , Behre H , et al.
ROS function as second messengers due to their ability to react with wide range of biomolecules resulting in modification of an array of signaling networks.
ROS , identified as signaling molecules , are responsible for maintaining redox homeostasis in vivo.
Rosiglitazone was not efficacious , even for apolipoprotein E ( APOE ) ε4 non-carriers ( MD @number@ @percent@ CI @number@ to @number@ ) .
ROS increased c-Jun , a critical member of transcription factor AP-1 complex , and increased c-Jun binding to the AP-1 site of the CCN1 promoter.
ROS induce skin aging through their damaging effect on cellular constituents.
ROS is generated via different cellular pathways and frequently arises in the mitochondrial electron transport chain as a by-product of oxygenic energy transduction.
ROS leads to mitochondrial dysfunction and chondrocyte death , which contributes to the development of OA.
ROS production is inevitably linked to ATP synthesis in most cells , and the rate of production is related to the rate of cell respiration.
ROS regulation of the Rac-GTPase , a required co-activator of many NOXes , is an example of this type of sensor.
ROSs were considered traditionally to be only a toxic byproduct of aerobic metabolism.
Rosuvastatin also shows anti-inflammatory and anti-atherosclerosis features , such as reducing carotid intima-media thickness and plaque area.
Rosuvastatin can also improve the prognosis of Chinese CHD patients , such as in the case of acute myocardial infarction.
Rotating night-shift work , which can disrupt circadian rhythm , may adversely affect long-term health.
Rotational speed was varied to estimate speed or temporal frequency thresholds in six conditions.
Rotator cuff injuries are a common clinical problem either as a result of overuse or aging.
Rotavirus ( RV ) P [ @number@ ] is an unique genotype that infects neonates.
Rothmund-Thomson syndrome ( RTS ) is a rare genetic disorder characterized by premature aging , developmental abnormalities , and a predisposition to cancer.
Rotifers have been used in biological research as well-characterized models of aging.
Roughly half the population follows the trajectory of mid onset and a quarter each of the other @number@
Roughly one third of eligible parents did not enroll , suggesting the need to increase awareness of parental eligibility and reduce barriers to enrollment.
Roughly one third of individuals with diabetes and prediabetes were identified by either FPG or A1c alone and by both tests simultaneously.
Roughly @percent@ and @percent@ fell at the < 10th and < 5th percentiles , respectively.
Routine assessments of frailty can be incorporated into patient counseling and decision-making for the EOC patient beyond simple reliance on single factors such as age.
Routine cerebrovascular pathological screening may miss subtle subcellular and molecular changes.
Routine claims data from six German sickness funds were analyzed and extrapolated to the German statutory health insurance ( SHI ) .
Routine Etest MIC testing of MRSA isolates is of limited value for treatment decisions.
Routine foot and nail assessment , clinically appropriate care , and individualized patient education are essential for achieving positive outcomes.
Routine genetic analysis of AR to confirm PAIS informs long-term prognosis and management.
Routine HRQOL screening may identify patients who could benefit from early interventions to improve HRQOL.
Routine identification of frailty is recommended in international guidance.
Routine laboratory test results captured into the study database , and serum testosterone measured within @number@ months after initiation of the baseline hemodialysis session.
Routinely , age estimation based on AAR is performed by analysis of dentine.
Routinely auditing mealtimes with MAT could be useful in identifying and removing barriers to food intake for older hospitalized patients.
Routine nuclear cardiology examinations indicate heart rate , cardiac rhythm , the height of cardiac pulse and respiration rhythm.
Routine RASS assessment of arousal during clinical care may be warranted as it correlates with prognosis.
Routine testosterone screening should be performed in all prediabetic men.
Rowe and Kahn's concept was used to measure SA.
Rowe and Kahn's model of successful aging highlights the interplay between social engagement with life , health , and functioning for a positive aging experience.
Rowers applied greater foot force and over a greater foot stretcher area with the high-density than the low-density and control insoles.
RPA displacement by WRN was independent of its ATPase- and helicase-dependent remodeling of the fork.
RPE and HR were assessed every @number@ min during each exercise session with @number@ data pairs.
RPE expressed more differentiated features on BCE-treated explants than on untreated explants , but expressed very little mRNA for bestrophin or RPE65.
RPE injury or degeneration may unlock mitotic block mediated by contact inhibition but may also promote epithelial-mesenchymal transition ( EMT ) contributing to retinal blindness.
RPE morphometric changes occur with aging.
RPE trophic factor mRNA expression was quantified by real-time PCR.
RPH3A loss correlated with dementia severity , cholinergic deafferentation , and increased β-amyloid ( Aβ ) concentrations.
RPL24 knockdown also reduced 80S subunit levels relative to 40S and 60S levels.
RPS was absent in five of the @number@ ( @percent@ ) slow injections in the elderly group.
RPTC treated with @number@ μM CYGAK-OC for @number@ h induced accumulation of ATP synthase β and NDUFB8 , two calpain @number@ substrates.
( R , R' ) -MNF caused significant inhibition of cell growth in β2-AR-expressing cells as monitored by radiolabeled thymidine incorporation and xCELLigence system.
RR results corroborated primary HR results , with additionally lower infection-related mortality in overweight and obese than in normal-weight individuals.
( R , R' ) [ ( R , R' ) -MNF ] is a highly-selective β2 adrenergic receptor ( β2-AR ) agonist.
Rs190590338 located in the promoter region was associated in the heterozygote form with an increased MASP-1 concentration of @percent@ ( P = @number@ ) .
Rs2854464 AA individuals were ∼2% stronger than G-allele carriers.
Rs3741916 showed the strongest LOAD association ( p = @number@ ) .
Rs405509 is a newly recognized AD-related polymorphism located in the APOE promoter region that can regulate the transcriptional activity of the APOE gene.
RSA had the greatest proportional increase over time , but only accounted for less than @percent@ of total interventions.
RS feeding did not cause heavy metal toxicity.
RS-fMRI results showed significantly reduced ( corrected P < @number@ ) DMN connectivity and altered fALFF activity in both MCI and AD groups.
RSL is influenced by prestorage variables and it might be associated with variable clinical outcomes.
RSR and SkBF were measured over each microdialysis membrane using ventilated capsules and laser-Doppler flowmetry.
Rs-SMR power in responders before start of ISC was higher in widespread parieto-occipital areas than in non-responders.
RSs were detected in @number@ subjects , occurring after impulses to both sides of the head in @number@ of these subjects.
RSTS is designed to deliver a localized stimulus to the peripheral vasculature , bone and muscle , without imposing a significant central cardiorespiratory strain.
RSV infections were shown to have no effect on the rate of decay of RSV-matAb.
RT001 Botulinum Toxin Type A Topical Gel ( RT001 ) is under development for the treatment of lateral canthal lines ( LCLs ) .
RT3DE is a reproducible method and a feasible tool for evaluating the LAV in children.
RT-dependent activity was observed in the bilateral posterior cingulate , supplementary motor area , and corpus callosum.
RT distribution parameters were not related to Ne / ERP-variability.
RTEC consumption was defined as daily , weekly , or infrequent use.
RTEC is a nutrient dense food , but should not replace the consumption of other healthy foods in the diets ' of elderly people.
Rtel1 was identified in mouse by its genetic association with telomere length.
RTEs are common in all kingdoms of life , and comprise close to @percent@ of mammalian genomes.
rTg4510 transgenic ( TG ) mice overexpress mutant ( P301L ) human tau protein.
RTH-RBCs showed slightly higher MDA concentration on days @number@ and @number@
RTIME increased ( P = @number@ ) pre to post ingestion in the caffeine condition but not in the placebo condition.
RT improves isokinetic strength and metabolic syndrome-related phenotypes in postmenopausal women.
RTL appears to be a marker reflecting changes in homeostasis associated with CKD that may contribute to the excess CVD risk.
RTL was measured by qPCR in @number@ out of @number@ GCKD patients at baseline.
RTL was not associated with WASO or self-reported sleep quality.
RTL was unrelated to HIV disease characteristics.
RT measurement in the Token Test could be used as a screening tool for linguistic slowing in the elderly population.
RT-PCR analysis revealed that the Oca2 transcripts were absent in the skin of NCT mice , suggesting intervention of the nonsense-mediated mRNA decay pathway.
RT-PCR assay was used to evaluate BubR1 expression in cultured hAoSMC stimulated with Angiotensin II or H ( @number@ ) O ( @number@ ) .
RT-PCRs and immunoblots showed higher expressional levels of TRPV2 in iPSC-ECs from HGPS patients than those from normal individuals.
RT-qPCR validates the expression of @number@ of @number@ assessed genes from different clusters.
RT recipients beyond the early acute posttransplant period , displayed serum testosterone levels and TDS prevalence similar to those of healthy controls.
RTS is caused by mutations in the RECQL4 gene , which encodes one of the five human RecQ helicases.
RT tuning curves exhibited a characteristic U-shape such that detection time increased with an increasing deviation from the participant's expected direction.
RT was divided in pre-movement-time ( PMT , time for stimulus processing ) and movement-time ( MT , time for motor response completion ) .
RT was divided in pre-movement-time ( PMT , time for stimulus processing ) and movement-time ( MT , time for motor response completion ) .
Rugby coaching theory suggests that rugby players need to possess various cognitive abilities.
Ruijs-Aalfs syndrome is a segmental progeroid syndrome resulting from mutations in the
Running , a popular form of exercise , is associated with the risk of developing injury , especially in older runners.
Runx1 transcription factor plays multiple roles in T cell development , differentiation , and function.
Rupture load ( N ) and extension were measured and graphed.
Rupture of abdominal aortic aneurysm ( AAA ) is a cause of significant mortality and morbidity in aging populations.
Rural African American adolescents participated in the Adults in the Making ( AIM ) program or a control condition.
Rural geriatricians were disproportionately scarce ( p < @number@ ) .
Rural health centers and those in the South had lower behavioral health and enabling services staffing.
Rural residents have been characterized as having a distinct culture , and health differences by residence have been well documented.
Russia had the highest prevalence of multimorbidity ( @number@ % ) whereas China had the lowest ( @number@ % ) .
Russian participants were more likely to be widowed and had lower self-rated health.
RVOT-VA in women were @number@ times more frequent than in men , while LVOT-VA were more frequent in men.
R ( Ω ) and Xc ( Ω ) values were standardized for stature ( H , m ) to obtain the classic bioelectrical values.
S100A4 Aging , though an inevitable part of life , is becoming a worldwide social and economic problem.
S100A8 / 9 , which is important in epithelial barrier function , was particularly decreased in elderly patients with CRS.
S100A9 was observed in some hippocampal and cortical neurons in TBI , AD and non-demented aging.
S1PD values differed up to @number@ g between genders.
S1R is an endoplasmic reticulum - ( ER ) resident transmembrane protein and is regulated by ER calcium homeostasis , which is perturbed in HD.
SA1- or TIN2-induced excess cohesion and anaphase delay can be rescued by overexpression of tankyrase @number@
SAA-deficient mice exhibited significant aging-associated differences in hepatic GSH , GSH / GSSG , ceramide , and nSMase.
SAA did not correlate with performance on tests of working memory.
Saccadic eye movements provide an opportunity to study closely interwoven perceptual , motor , and cognitive changes during aging.
Saccadic impairment in Alzheimer's disease ( AD ) was found in horizontal saccades.
Saccadic latency and accuracy are related to visual threshold , suggesting that saccadic latency and accuracy could be useful as perimetric outcome measures.
Saccadic reaction latencies also were doubled in high-risk older adults compared to young.
Saccharomyces cerevisiae Sir2 is an NAD ( + ) -dependent histone deacetylase that links chromatin silencing to genomic stability , cellular metabolism and lifespan regulation.
Sacral curvature angle and lumbosacral lordotic angle were noted.
Sacral neuromodulation may represent a viable , minimally invasive treatment option for some older adults.
SA didn't differ across classes.
Sad or neutral mood was induced by texts and music pieces.
SA during pregnancy seems partly to be associated with different factors than SA in general.
Safe and reliable application of the endoscopic technique depends on several important factors.
Safe pain management in older patients therefore requires cautious choice of selective and nonselective oral NSAIDs , topical NSAIDs or non-NSAID analgesics.
Safer and more efficient methods of reprogramming are rapidly being developed.
Safe Routes uses a toolkit based on the 5-E model providing practical resources to guide stakeholders in meeting the needs of the community.
Safety and clinical efficacy of NAFT are well established in multiple studies.
Safety concerns together with aging of the driving population has prompted research into clinic-based driving assessments.
Safety of the stem cell therapy can be declared from these clinical trials , but efficacy warrants further investigations.
Safety parameters are also documented ( adverse events and serious adverse events ) .
Safety profiles were assessed by physician-reported adverse drug reactions ( ADRs ) .
Safety was assessed according to reported adverse events ( AEs ) and serum antibody measurement.
Safety was assessed from adverse events at all study visits.
Safety was assessed with the Mini Mental State Examination ( MMSE ) .
Safety was demonstrated in @number@ patients with only @number@ minor complications of small lateral granuloma which all resolved within @number@ weeks after intralesion triamcinolone injection.
Safety was investigated by querying users about adverse events after every session.
SAF may in the future be a helpful tool to predict vascular and metabolic dysfunction ( early signs of aging and pathology ) .
SAF was non-invasively determined using an autofluorescence spectrometer.
Sagittal balance tended to be retained even in elderly subjects if lumbosacral lordosis was large enough to compensate for thoracic kyphosis.
Sagittal plane motion and net external sagittal and frontal plane moments were calculated.
SAHS physiopathology is multifactorial in which airway compliance is a very important component.
Salicin , an extract from white willow bark , has been researched as a potent anti-inflammatory agent when taken orally.
Salicylates have been used as analgesics and antiinflammatory agents for several decades.
Salience processing provides motivational context to stimuli.
Salient differences between typically aging vs. healthy aging older adult norms are discussed.
Saline injections was adopted in saline group , DESCs group was treated with DESCs transplantation.
Saline or @number@ µg , @number@ µg , to @number@ µg / day / mouse of sRAGE were injected intraperitoneally daily for @number@ days.
Saline solution was used as irrigation to treat the patients with acute necrotizing fasciitis.
Salivary 17β-estradiol did not correlate with recalled list @number@ or list @number@ items in either remember- or forget-cued young women.
Salivary amino acids were recovered after deproteinization with @percent@ trichloroacetic acid and determined by an amino acid analyzer.
Salivary cortisol , alpha-amylase and heart-rate responses to stress were assessed before , during and after stress induction.
Salivary cortisol and alpha-amylase are known to have distinctive diurnal profiles.
Salivary cortisol , cardiovascular , and subjective stress were assessed throughout the experiment.
Salivary cortisol samples ( wakening , @number@ min after wakening and evening ) were collected at the same age.
Salivary cortisol samples were collected at @time@ , @time@ , and @time@ , @number@ day after memory testing.
Salivary cortisol samples were obtained from @number@ nondemented subjects aged at least @number@
Salivary cortisol was measured with @number@ timed samples at the beginning , middle , and end of a 2-hr in-home interview.
Salivary levels of pubertal hormones ( testosterone , DHEA and oestradiol ) were also measured.
Salivary measures have emerged in bio-behavioral research that are easy-to-collect , minimally invasive , and relatively inexpensive biologic markers of stress.
Salivary samples were collected at home over @number@ days at awakening , 30-min after waking , afternoon , and evening periods to determine cortisol levels.
Salivary samples were collected at rest and @number@ minutes after the @number@ water-based exercise protocols.
Salivary samples were collected before and after each workout , at @time@ .m. and at @time@ . of the following day.
Salivary telomere length ( STL ) was determined from salivary DNA using quantitative polymerase chain reaction.
Saliva samples for cortisol assessment were collected at @number@ @number@ and @number@ min after awakening.
Saliva samples were collected from caregivers five times a day for @number@ consecutive days and were assayed for DHEA-S.
Saliva was collected using the spitting method at @time@ .
Salive was also collected during a non-training day.
Salmonella typhimurium is a facultative intracellular bacterium that causes gastroenteritis in humans.
Salt and energy intake were calculated from 3-day diet records with photographs.
Salt behaviour and sociodemographic data are captured using face-to-face interviews , alongside blood pressure and anthropometric measures.
Salts of copper chlorophyllin complex are semi-synthetic naturally derived compounds with anti-oxidant and wound healing activity that has not been previously tested in photodamaged skin.
Sam68-deficient adipocytes express Rps6kb1-002 and its encoded p31S6K1 protein , in contrast to wild-type adipocytes that do not express this isoform.
Sam68 null preadipocytes were monitored for alternative splicing imbalances in components of the mTOR signaling pathway.
SA may in turn increase the long-term mortality in the geriatric patients ; however , it remains unclear.
Same-gendered and near-aged participants were selected and were instructed to collect their urine in sterile nickel-free plastic containers.
Same respiratory manoeuvres were also performed at rest.
Same results were observed at 1-year follow-up ( @number@ % CI = @number@.85-9.84 ; p = @number@ ) .
Same substance stability was greatest in adulthood.
SAMP10-ΔSglt2 mice may serve as a unique preclinical model to study the link between aging-related neurodegenerative disorders and T2D.
Sample consisted of @number@ community-dwelling elderly , in São Paulo , Brazil.
Sample consisted of @number@ men , aged 42-61 years at baseline.
Sample consisted of @percent@ men with a mean ( SD ) duration of @number@ ( @number@ ) yrs postinjury ; @percent@ reported using a wheelchair.
Sample fracture load was measured by a bending test.
Sample persons ( n = @number@ ) who resided in their own or another's home at T1 were included.
Sample preparation involved hydrolysis of menadiol conjugates and oxidizing the released menadiol to menadione.
Sample proportions were weighted to reflect the prevalence in the U.S. population of @number@
Sample results are presented for a human lens of age @number@ years.
Sample results can be generalised ( men @percent@ , at least @number@ years old @percent@ , smallest / small enterprises @percent@ ) .
Samples consisted of subjects from two populations of European ancestry.
Samples from infants aged < 1 year were used to verify the calculated RI with evaluator protocol C28-A3.
Samples from @number@ women and @number@ men taking LTG and @number@ women and @number@ men taking OXC were used to develop a population pharmacokinetic model.
Samples from the patients were anonymous and only data with regard to age and gender was available at sample collection.
Sample size calculations indicate that @number@ participants need to be recruited into the longitudinal study , with @number@ participants randomized into the trial arms.
Sample size calculations resulted in a need for a total sample of @number@ patients.
Sample size ranged from @number@ to @number@ SNPs were imputed to the @number@ Genomes European panel.
SAMPLE SIZE : six residents.
Sample sizes ranged from @number@ to @number@
Sample sizes range from @number@ to @number@ ( median = @number@ ) , yielding @number@ subjects and @number@ all-cause deaths.
Sample sizes to power presymptomatic clinical trials based on rate of atrophy were calculated.
Sample sizes were limited among patients aged ≥75 years.
Sample sizes were @number@ ( self-report analyses ) and @number@ ( speech-in-noise test analyses ) .
Sample size varied at each assessment with an average of @number@ ( range 212-1096 ) .
Sample size was @number@ @number@ and @number@ respectively.
Sample size were @number@ the prevalence rate of blindness and low vision were @percent@ per hundred and @percent@ per hundred , respectively.
Samples of milk , whey , curd , and cheese were collected for enumeration of bacteria throughout the manufacturing and aging process.
SAMPLES : Published randomized trials and population-based studies since @number@
SAMPLE : Sub-groups from a cohort of @number@ women , of whom @number@ met enrollment criteria.
Samples were aged by thermocycling and water bath.
Samples were analyzed by immunohistochemistry , quantitative real-time polymerase chain reaction , and zymography.
Samples were collected from the units at storage days @number@ @number@ @number@ @number@ @number@ @number@ and @number@ respectively.
Samples were divided in @number@ groups : younger ( ages 21-45 ) and older ( ages 66-78 ) .
Samples were divided into three age groups : G1 , 19-40 years ; G2 , 41-60 years ; G3 , > 61 years.
Samples were examined by epifluorescence microscopy.
Samples were fed in @number@ rounds on the same day : blind and informed testing.
Samples were fixed in @percent@ formaldehyde in phosphate buffer and were evaluated histologically.
Samples were genotyped using the Illumina Human610-Quad BeadChip.
Samples were selected across the adult lifespan from @number@ to @number@ years of age.
Samples were split and tested by the two methodologies at a Quest Diagnostics national reference laboratory. cFT was calculated by the Vermeulen method.
Samples were taken at multiple specified time points across two non-consecutive days in the home and one day at the study sites.
Samples were taken every week for up to @number@ weeks and exposed to various stress conditions , such as hyperosmotic shock and energy depletion.
Samples were taken upon waking , @number@ min later , and then approximately every @number@ h until @time@ .
SAMPLE : twenty residents.
Sample weights were created.
Sample weights were used to ensure result generalizability.
Sampling bias should be considered when interpreting findings.
Sampling was both convenience and purposive.
Sampling was guided by constructivist grounded theory and data collected using open-ended , semi-structured interviews.
Sampling was performed using quarterly human landing catches , monthly Prokopack automated aspirators and monthly Biogents-sentinel traps.
Sandblasting treatment exerts a beneficial effect on shear bond strength.
Sandwich ELISA assays revealed significantly reduced soluble Aβ levels in the SS31-treated APP mice relative to the untreated APP mice.
\ "Sandwich moms \ " are likely to bear the brunt of the ravages of this storm.
Sanger sequencing of CKAP2L in a further eight unrelated individuals with clinical features consistent with Filippi syndrome revealed biallelic mutations in four subjects.
Saphenous veins were collected from patients undergoing coronary artery bypass graft surgery.
Saprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients and scarce evidence is available for treatment decisions.
Sapropterin increased pharmacologically induced vasoconstriction at the Ringer site ( @number@ ± @number@ vs. @number@ ± @number@ ΔCVC ; P = @number@ ) .
Sapropterin increased reflex vasoconstriction at the Ringer site at Tsk ≤ @number@.5°C ( P < @number@ ) .
Sarcoidosis is a systemic disorder of unknown cause characterized by its pathological hallmark , the non-caseating granulomas , and by variable clinical course.
Sarcoidosis patients were significantly younger than EAA group and had significantly better lung functions ( VC , FEV1 , TLCO ) .
Sarcopenia and cachectic muscles have been demonstrated to be abundant in myostatin-linked molecules.
Sarcopenia and cognitive decline could , therefore , produce slow gait velocity in older persons , with devastating effect and consequences.
Sarcopenia and lower serum 25-hydroxyvitamin D concentrations have been independently associated with poor physical performance and UI and were therefore included as secondary outcomes.
Sarcopenia and obesity share several pathophysiological mechanisms , and they may potentiate each other.
Sarcopenia and osteoporosis are risks of falls and fractures , and the risk for disability is also high.
Sarcopenia and osteoporosis are two sides of the same coin.
Sarcopenia and severe sarcopenia were defined according to the @number@ consensus of the Report of the European Working Group on Sarcopenia in Older People.
Sarcopenia and weakness are known to precipitate risk for disability , comorbidity , and diminished independence among aging adults.
Sarcopenia , a newly recognized geriatric syndrome , is characterized by age-related decline of skeletal muscle plus low muscle strength and / or physical performance.
Sarcopenia corresponds to the loss of muscle mass occurring during aging , and is associated with a loss of muscle functionality.
Sarcopenia describes reduced skeletal muscle mass and impaired muscle function associated with aging and with a variety of chronic diseases prevalent in the aging population.
Sarcopenia developed at a higher rate with incident UI ( adjusted odds ratio [ OR ] @number@ @percent@ CI @number@.0-2.9 ) .
Sarcopenia = / = dynapenia.
Sarcopenia encompasses the loss of muscle mass and strength / function during aging.
Sarcopenia incidence was documented after one year of follow-up , and correlated with several possible factors.
Sarcopenia index had a significant correlation with the conventional diagnostic parameters of sarcopenia.
Sarcopenia is a catabolic pathway common of the aging process and also associated with CHD.
Sarcopenia is a common and prominent geriatric syndrome , of major interest for daily clinical practice of professionals working with older people.
Sarcopenia is a highly prevalent condition in older persons that leads to disability , hospitalization , and death.
Sarcopenia is a major public health issue.
Sarcopenia is an emerging risk factor for metabolic disorders.
Sarcopenia is a notable and debilitating age-associated condition.
Sarcopenia is a relatively new concept in the medical literature , initially intended to describe the loss of lean body mass that occurs with aging.
Sarcopenia is characterized by decreases in both muscle mass and muscle function.
Sarcopenia is characterized by structural , biochemical , molecular and functional muscle changes.
Sarcopenia is closely linked to an increase in the risk of hip-femur fractures , inflammation , edema , and malnutrition.
Sarcopenia is considered to be one of the major factors responsible for functional limitations and motor dependency in elderly persons.
Sarcopenia is defined as an age-related decrease in muscle mass and performance.
Sarcopenia is defined as an age-related loss of skeletal muscle mass and function and is recognized as a major clinical problem for older people.
Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of muscle mass and strength.
Sarcopenia is defined as the age-related loss of muscle mass and function.
Sarcopenia is diagnosed by a decrease in skeletal muscle index ( SMI ) and reduction of either handgrip strength or gait speed.
Sarcopenia is prevalent in patients with chronic kidney disease ( CKD ) and associated with increased morbidity and mortality , as well as cardiovascular complications.
Sarcopenia is the age-associated loss of lean skeletal muscle mass.
Sarcopenia is the age-associated loss of muscle mass and is one of the main contributors to musculoskeletal impairments in the elderly.
Sarcopenia is the age-associated loss of skeletal muscle mass and strength.
Sarcopenia is the age-related loss of muscle mass and strength.
Sarcopenia is the loss of skeletal muscle mass and function with aging.
Sarcopenia is the progressive generalized loss of skeletal muscle mass , strength , and function which occurs as a consequence of aging.
Sarcopenia makes the physical act of toothbrushing more challenging.
Sarcopenia may be an early predictor for diabetes and MS susceptibility in the non-obese population , particularly in elderly people.
Sarcopenia may cause decrease in PCF in the elderly , which may stand for some common adverse respiratory complications.
Sarcopenia of age is prevalent and costly and proven pharmacological interventions are currently lacking.
Sarcopenia refers to the progressive loss of muscle mass and muscle function and is a contributing factor for cachexia , bone loss , and frailty.
Sarcopenia represents a loss of muscle strength and mass in older individuals.
Sarcopenia status was determined according to the EWGSOP guidelines.
Sarcopenia , the age related loss of muscle mass and function , may add to fracture risk by increasing falls risk.
Sarcopenia , the degenerative loss of skeletal muscle mass , strength and quality associated with aging , interferes in particular with the oropharyngeal phase.
Sarcopenia , the progressive loss of muscle mass and strength , is a phenomenon characterizing human aging whose etiology is still not clear.
Sarcopenia was classified according to both criteria.
Sarcopenia was defined according to the Asian Working Group for Sarcopenia ( AWGS ) criteria.
Sarcopenia was defined according to the criteria for the Asia Working Group for Sarcopenia.
Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People criteria using bioimpedance analysis for muscle mass assessment.
Sarcopenia was defined as low ALM-to-body mass index ( BMI ) -ratio using validated sex-specific cutoffs.
Sarcopenia was defined using the algorithm of the European Working Group on Sarcopenia in Older People ( EWGSOP ) .
Sarcopenia was measured using total psoas area at the L-4 vertebra on perioperative CT scans.
Sarcopenia was present in @percent@ of the sample , ranging from @percent@ in the poultry cluster to @percent@ in the alcoholic drink cluster.
Sarcopenia was significantly related to low body mass index , smaller waist circumference , poor nutrition and poor cognition.
Sarcopenia , which is defined as age-related loss of muscle mass , is considered to be a central manifestation of frailty.
Sarcopenic non-obese and non-sarcopenic obese subjects were not associated with an increased 10-yr CVD risk.
Sarcopenic obese men did not have significantly different total hip BMD over @number@ years compared with non-sarcopenic non-obese men ( p > @number@ ) .
Sarcopenic obese men had the highest risk of all-cause mortality but not CVD mortality.
Sarcopenic obesity , but not non-sarcopenic obesity , was closely associated with an increased CVD risk in Korean adults.
Sarcopenic obesity was more prevalent in women ( @percent@ ) than in men ( @percent@ ) .
Sarcopenic participants with low height-adjusted or weight-adjusted skeletal muscle index ( SMI ) were classified as having h-sarcopenia or w-sarcopenia , respectively.
Sarcopenic patients also had greater pharmacy , laboratory , respiratory care , and emergency department costs.
Sarcopenic patients are likely to have worse clinical outcomes and higher mortality compared to healthy individuals.
Sarcopenic patients were @number@ times as likely to require a blood transfusion ( @percent@ vs @percent@ , p = @number@ ) .
SA reported in visits increased from @number@ in @number@ to @number@ in @number@ with an annual per capita visit reporting rate of @percent@ to @percent@.
Sarkosyl-insoluble and soluble tau investigated by immunoblotting.
Sarpogrelate is an antiplatelet agent widely used to treat arterial occlusive diseases.
SAS @number@ was used for statistical analysis.
SASP in brain could contribute to age-related inflammation and chronic neurodegenerative diseases.
SAS-R cells continue to proliferate when exposed to fractionated radiation ( FR ) of @number@ Gy / day for more than @number@ days in vitro.
SAT and TAT specimens were obtained from @number@ patients undergoing cardiac surgery , making these tissues readily available as a prime source of adipose tissue.
Satellite cell regenerative functions decline with ageing.
Satellite cells are mitotically quiescent or slow-cycling , committed to myogenesis , but undifferentiated.
Satellite cells are one of the well-studied adult tissue-specific stem cells and have served as an excellent model for investigating adult stem cells.
Satellite cell ( SC ) proliferation and differentiation have critical roles in skeletal muscle recovery after injury and adaptation in response to hypertrophic stimuli.
Satellite cells express high levels of FGF receptors @number@ and @number@ low levels of FGF receptor @number@ and little or no detectable FGF receptor @number@
Satiety measures did not differ between groups throughout the test.
Satisfaction was also assessed.
Satisfaction was as high as @percent@ among patients treated primarily for hollowness , and the overall satisfaction rate was @percent@.
Satisfaction was examined by descriptive statistics.
Satisfaction was high and not different between groups ( P = 0.059 ) .
Satisfaction with life domains was robustly and positively associated with good successful aging outcomes.
Satisfaction with life , sufficient income , physical activity , volunteerism and mental workload were considered positive associations that protect the elderly from functional loss.
Satisfaction with living standards showed the strongest negative association with change in restless sleep reports.
Satisfaction with present life showed the strongest mitigating direct effect on depression.
Satisfactory measurement invariance was established across time and cohorts.
SAT is prone to \ "browning \ " - the appearance of particular beige adipocytes that contribute to its favorable metabolic effects.
SAT macrophage markers were not predictive for VAT macrophage markers.
SAVI provides a testable model to understand the literature on emotion and aging and to predict trajectories of emotional experience across the adult life span.
Savoring is associated with positive outcomes for people with higher and lower levels of resilience.
SA was measured as a ratio of days on SA divided by potential working days.
SB did not decline with age until @number@ years , and then decreased significantly thereafter.
SBGE-activated caspases @number@ and @number@ and increased reactive oxygen species generation.
SBGE suppressed mitochondrial membrane potentials and SBGE-induced apoptotic cell death was identified to be associated with downregulation of Bcl-2 , but upregulation of Bax.
SBGE was administered to cells at concentrations between @number@ and @number@ mg / ml , and cell viabilities were identified using an MTT assay.
S-BIS can evaluate electrical properties that may be related to muscle force production.
SBM related to disproportionately enlarged cortical and putamen and reduced hippocampus volumes.
SBO resolution was successful in 29 / 32 ( @percent@ ) patients.
SBP and DBP decreased after 8-week black soy peptide supplementation versus controls ( P < 0.001 ) .
SBP and PP increased with age to a higher degree in patients with the MetS.
SBP increased between the first two measures in @percent@ , decreased in @percent@ and did not change in @percent@ of the population.
SBP was converted to age- , gender- and height-specific z-scores ( SBPz ) .
SBP was measured at baseline and again at resurvey in 2001-2004.
SBP was significantly decreased in the older population postdrumming ( @number@ ± @number@ vs. @number@ ± @number@ mmHg ; P < @number@ ) .
SBRN ultrasonographical Asc was comparable to histological Asc.
SBS measured with each bonding concept surpassed this value , except control and MaxCem after @number@ d.
SBS values were inadequate for a sufficient ranking.
SCA31 has recently been reported to be associated with a complex penta-nucleotide ( TGGAA ) n repeat insertion in the introns of TK2 and BEAN.
SCA3 and Huntington's disease ( HD ) belong to a family of polyglutamine neurodegenerative diseases.
Scaffold and barrier nucleoporins are two major types of protein building blocks that make up the NPC.
Scaffold proteins coordinating signaling pathways in time and space play a critical role in this process.
SCAI undergoes prominent enrichment at DSB sites through dual mechanisms involving 53BP1-dependent recruitment to DSB-surrounding chromatin and 53BP1-independent accumulation at resected DSBs.
Scalar invariance testing identified the Buschke Cued Recall Test and Block Design as measures with invariant factor loadings but noninvariant intercepts.
Scale development involved both online photographs and live assessments of subjects.
Scale relevancy index equaled @percent@ and scale clarity index equaled @percent@.
Scalp alopecia progressed in a distinct pattern , with preservation of the hair over the midscalp and vertex areas for the longest period of time.
Scalp electroencephalography , memory accuracy , and reaction times were measured.
SC and CO stimuli were equally effective in supporting vowel identification except when acoustic information was limited to @number@ ms.
Scanning electron microscopy observations revealed morphological alterations in hair coat of Padi3 knockout mice.
Scanning electron microscopy ( SEM ) and immunofluorescence images indicated the presence of NETs after treatment with cationic liposomes.
Scanpaths have played an important role in classic research on reading behavior.
Scan-rescan reliability was assessed using the coefficient of variation ( CV ) and intraclass correlation ( ICC ) in eight subjects with three scans each.
Scans were obtained at encoding and retrieval.
Scapular kinematics in healthy adults is well described in the literature but little is known on typical children.
Scar severity is also shaped by interactions between these local factors and genetic and systemic factors such as hypertension and sex hormones.
SCA type @number@ showed lower metabolic ratios in almost all cerebellar subregions ( ANT , @number@ ± @number@ p < @number@ ) except INFV.
Scavenging and reverse transport of atherogenic oxidized lipids by high-density lipoprotein ( HDL ) was recently suggested to contribute to atheroprotection.
Scavenging reactive oxygen species ( ROS ) or inhibiting NADPH oxidase activity rescued loss of neuronal motility and morphology.
SCA was identified in @percent@ of participants.
SCA was not related to demographic composition , HIV disease or treatment factors , medical comorbidities , or histories of substance use disorders.
SCC mortality and survival rates remained relatively stable.
SCD rather echoes depressive symptoms in both patients with MCI and healthy subjects.
SCD was positively associated with depressive symptoms in both groups.
Scenes were presented either from an egocentric or allocentric viewpoint.
SCF complexes degrade proteins during the G1 phase.
SCF ligases are constitutively active and generally target only proteins after they have been selected for degradation , usually by phosphorylation.
Sch B and schisandrin C ( Sch C ) increased cellular reduced glutathione ( GSH ) level and protected against solar irradiation-induced oxidative injury.
Schistosomiasis infection rate was affected by host sex as males had higher infection rate than females.
Schizophrenia and related disorders have a major genetic component.
Schizophrenia , illicit drug and pharmaceuticals abuse are strongly positively associated with psychiatric and nurse HCU.
Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset.
Schizophrenia is one of the most serious mental diseases found in humans.
Schizophrenia patients needed relatively more trials to learn the first PCET category than the second or the third.
Schizophrenia patients performed worse than elderly healthy on abstraction , inhibition and verbal working memory.
Schizophrenia patients with antisocial behaviour problems had two and a half times higher drop-out rates.
Schizophrenia symptoms were assessed using the Positive and Negative Syndrome Scale ( PANSS ) .
SCH might augment and worsen the effects of aging on serum lipid profiles.
Schmorl's nodes with perifocal enhancement on MRI result in higher FDG uptake.
Scholars argue about whether age stereotypes ( beliefs about old people ) are becoming more negative or positive over time.
Scholars who study how social networks affect older adults ' health are often concerned with the prospect of declining social connectedness in late life.
Scholars , working in either academic or practice environments , provided points of difference on scholarship.
School-based screenings were conducted annually by the local government from April to June.
Schooling and job affect the performance obtained when dealing with verbs in the vocabulary test.
SC hydration on the canthus of both aged males and aged females is significantly lower than that of young subjects.
Science now asks how long can humans live , but we suggest a more appropriate question is : How long must humans live ?
Scientific achievements in the last few decades , leading to effective therapeutic interventions , have dramatically improved human life expectancy.
Scientifically , however , it has overturned Alois Alzheimer's age-based concept for disease classification-the essence of modern Geriatric Medicine and the National Institute of Aging.
Scientific data on conditions of blood supply in the skin during aging are insufficient and contradictory.
Scientific discoveries over the past two decades have been instrumental in dissecting molecular mechanism ( s ) which play important roles in determining longevity.
Scientific efforts for the evaluation of specific training programmes can be expected ; implementation of the results into clinical practice is desirable.
Scientific evidence links physical activity to several benefits.
Scientific interpretations for various preventive treatments in TCM present the idea that disease prevention should surpass medical intervention in humans.
Scientific literature has been quickly expanding as the availability of articles in electronic form has increased rapidly.
SCIENTIFIC SIGNIFICANCE : Successful smoking cessation makes patients appear biologically younger than they were at baseline , and to do so quite rapidly.
Scientists have been experimenting to find methods to prevent the memory loss associated with aging.
Scientists have presented evidence that systemic aging is influenced by peculiar molecules in the blood.
Scientists have worked for over a century to uncover the basis of Alzheimer's disease ( AD ) with the ultimate goal of discovering a treatment.
Sci. , @number@ pp. 1137-1145 ) .
SCI was assessed by a validated self-reported questionnaire.
Scleral material properties were fit to each eye using a microstructure-based constitutive formulation that incorporates the collagen fibril crimp and the local anisotropic collagen architecture.
Scleral thickness measurements were not significantly ( all P > @number@ ) associated with adult glaucoma.
Sclerostin , a Wnt signaling pathway antagonist produced by osteocytes , is a potent inhibitor of bone formation.
Sclerostin increased during BR across groups ( P = 0.016 ) .
Sclerostin is a soluble antagonist of Wnt / β-catenin signaling secreted primarily by osteocytes.
Sclerostin was heritable , and nine SNPs in the SOST gene region were associated with sclerostin.
SCOPE : Curcumin , a component of the spice turmeric , was tested for its potential hormetic anti-aging effects as an inducer of mild stress.
SCOPE : Leukocyte telomere length ( LTL ) is an important biomarker of aging.
SCOPE : @number@ young adults , @number@ older adults , and @number@ individuals with moderate knee OA were recruited.
SCOPE OF REVIEW : In this paper , we review the role of AGE-oxidative stress axis and its therapeutic interventions in vascular complications in diabetes.
SCOPE OF REVIEW : S-Nitrosylation directly modifies a number of cytoplasmic and nuclear proteins in neurons.
SCOPE OF REVIEW : This review presents recent findings about the structure , biosynthesis , and pathology of O-mannosyl glycans.
SCOPE OF REVIEW : We review the recent progress toward therapeutic and preventive applications of hydrogen.
SCOPE provided self-care education targeted at older people with low income and low education in order to improve health-related knowledge.
SCOPE : Tissue concentrations of omega-3 fatty acids may reduce cardiovascular disease risk , and genetic variants are associated with circulating fatty acids concentrations.
SCOPE was also designed to provide information for policy makers on chronic disease burden and healthcare facility utilization among community-dwelling older adults.
SCOPE : Zinc deficiency results in immune dysfunction and promotes systemic inflammation.
Scopolamine significantly impaired performance of aged , but not young dogs.
Scopus was searched for studies using healthy subjects and that reported means of P300 latency and amplitude measured at Pz and mean age.
Scores between @number@ and @number@ were considered indicative of subthreshold depression.
Scores calculated from the full and short FFQ were compared with nutrient intake and blood concentrations of vitamin C and lipids.
Scores did not differ significantly between departments or between the before and after measurements related to an innovative intervention study in healthcare delivery.
Scores for each domain from individual cognitive measures were converted to z-scores and then averaged to produce a composite score.
Scores for each test were summed to a total performance score ( range 0-12 ) , higher scores indicating better performance.
Scores for TUG and WS indicated relatively poor physical function , yet these measures were not associated with muscle mass or indices of sarcopenia.
Scores given by experienced otolaryngologists expert in treating dysphagic subjects correlated significantly with those of nonexpert otolaryngologists and speech-language-hearing therapists.
Scores of LTPA were obtained by questionnaire.
Scores on both SIB scales were moderately associated with functional measures at baseline and week @number@
Scores on Mini Mental State Examination , immediate and delayed recall tests , and tests for simple and complex speed were compared for both groups.
Scores on nine individual measures and the global Personal Well-being Index ( PWI ) were compared to national , normative data.
Scores on @number@ cognitive tests were related to scores on Neugartens ' LS index A ( LSI-A ) @number@ years later.
Scores on the non-memory scales have lower accuracy and are not recommend for predicting high-risk cases unless all non-memory subdomain scores are combined.
Scores on the non-memory subscales generally had high sensitivity but low specificity.
Scores on the RD nutrition risk rating and the Toddler NutriSTEP were correlated ( r = @number@ p < @number@ ) .
Scores on the Sense of Authenticity Scale increased across age cohorts.
Scores ranged from 0-56 with higher scores indicating increased stress.
Scores using this tool range from 0-120 ( higher scores indicate greater mobility ) .
Scores were analysed using General Linear Mixed Models.
Scores were between @number@ and @number@
Scores were compared between those with and without diabetes at age @number@
Scores were created for barrier domains.
Scores were discussed and refined during consensus meetings , resulting in a taxonomy of clinical features.
Scores were lower for surgical than medical or disease-specific ICUs.
Scores were reasonably stable over the 1-month period studied , at least for the children's sample employed.
Scoring protocols and interpretations were developed for each measure.
Scorings were performed under specific scales as established by a previously published referential Skin Aging Atlas , Volume @number@ Asian Type.
Screening and brief intervention ( SBI ) is increasingly available to older adults who engage in at-risk drinking.
Screening and referral in acute care could result in earlier diagnosis and treatment.
Screening at admission with algorithms of care that include referral to the dietitian are needed to improve the process of nutrition care.
Screening-based intrapartum antibiotic prophylaxis ( IAP ) for pregnant women , an effective strategy in high-income countries , is often not practical in these settings.
Screening colonoscopies have been offered as a primary screening tool in Germany since the end of @number@
Screening for colorectal cancer ( CRC ) is implemented in an increasing number of countries.
Screening for early detection of intracranial neoplasms among aging survivors of childhood cancer who received CRT should be evaluated.
SCREENING FOR FRAILTY : The BGS does not recommend population screening for frailty using currently available instruments.
Screening for HLA-B5701 to avoid abacavir hypersensitivity reactions has become a routine part of clinical care , and has markedly improved drug safety.
Screening for low FMR1 CGGn < @number@ at young age , thus , appears predictive of later PDFOR.
Screening for prediabetes did not increase the number or costs of drug prescriptions.
Screening for SRBD is indicated in some conditions , which are discussed.
Screening for this genetic variation may have predictive value in assessing potential longevity of subjects in China , as well as in the Western world.
Screening has been shown to reduce colorectal cancer incidence and mortality , but organised screening programmes are still to be implemented in most countries.
Screening , monitoring , and reducing stress in multiple life domains presents an opportunity to improve HRQoL outcomes for caregivers.
Screening must be considered as part of the health sector planning for the future and include the high risk younger age groups.
Screening of individuals with major risk factors of CKD , in order to early detection and treatment of impaired renal function , may be plausible.
Screening of patients with cirrhosis using the CRT index , therefore , identifies brain dysfunction rather than effects of gender and age.
Screening parameters and disease prevalence were calculated.
Screening pathways are being investigated and some are discussed in this review.
Screening programs in Nepal may assist early intervention in hypertensive patients with sub clinical depression.
Screening questions by healthcare professionals could be a means to identify , assess and treat older people with UI.
Screenings of C9ORF72 in other Middle East countries will reveal whether the low contribution of C9ORF72 to ALS is a feature of the entire region.
Screening tests for diabetes mellitus include fasting plasma glucose ( FPG ) and glycated hemoglobin ( HbA1c ) .
Screening tools can be used to detect elder abuse.
Screening uptake was @percent@ among those with adequate and @percent@ among those with limited health literacy skills.
Scrib is a membrane protein that is involved in the maintenance of apical-basal cell polarity of the epithelial tissues.
SCRT also increased death receptor-associated ligands and enhanced the activation of caspase-8 and cleavage of its substrate Bid.
SC-treated LL at 7d postmortem had a lower WBSF than those of CC-treated at 14d.
S-Cu levels were highest in ≥10h sleep.
SCUs have on average three patients per carer on an ordinary weekday day-time shift.
SDD after complex PCI was associated with younger age and more frequent use of forearm access.
SD-EEG consisted of waking up patients at @time@ and performing video EEG at @time@ .
SDF-1 has pleiotropic roles in bone formation and BMSC differentiation into osteoblasts / osteocytes , and in osteoprogenitor cell survival.
SDHC is a subunit of mitochondrial complex II.
SDLT scores were also significantly lower by @number@.38s ( P = 0.05 ) .
SDM brought about morphological changes to differentiated SH-SY5Y cells , particularly to neuronal processes.
SDM may be a biologically relevant polymeric melanoid that we previously showed exhibits redox activity and disrupts lipid bilayers.
SD-OCT provided useful information about topographic thickness of the different corneal layers in vivo.
SDS-PAGE showed decreased protein levels at ∼20 kDa in ARNC lenses but significantly increased levels at HMW ( > 200 kDa ) .
SE = 0.12 ) .
SE = 0.12 , great suffering : β = 0.15.
SE = 0.14 , severe suffering : β = 0.03.
Searched outcomes included survival , clinical and nutritional parameters and complications.
Searches involving PubMed / MEDLINE , EMBASE , SCOPUS and Web of Science will be used to identify systematic reviews and meta-analyses of observational studies.
Searches were combined to find reports addressing @number@ or more keywords.
Searches were conducted in EMBASE and MEDLINE ( by @date@ ) and additional datasets were obtained from study investigators.
Searches were limited to articles published in English with no restriction imposed to date of publication.
Searches were limited to the English language.
Search for scientific information on the relation fatty liver with the development of atherosclerotic lesions of arteries.
Search functions facilitate retrieval of data which can also be exported for further processing.
Search included systematic reviews , meta-analyses , controlled trials , cohort studies , case-control studies and transversal studies published until @date@ .
Searching for extractable triterpenoids in oak heartwood , @number@ new , 1-12 , and five known , 13-17 , oleanane types were isolated and characterized.
Search is a prerequisite for successful performance in a broad range of tasks ranging from making decisions between consumer goods to memory retrieval.
SEARCH METHODS : We searched CENTRAL , MEDLINE , Embase , PsycINFO , CINAHL and two clinical trials registers on @date@ .
Search results were rapidly screened to identify articles of relevance.
SEARCH STRATEGY : Medline , Embase , Cinahl and Cochrane were searched.
SEARCH STRATEGY & SOURCES : MEDLINE , Embase , PsycINFO , CINAHL , and reference lists were searched to @date@ .
Search terms included cheek ; lip ; reconstruction ; vascular anatomy , soft-tissue anatomy , aging face , outcomes , and perforator flap.
Search terms included dementia , elderly , prison and criminal.
Search terms included \ "frontotemporal dementia \ " , and words related to non-pharmacological management , and it identified a total of @number@ articles.
Search terms included were community integration , traumatic brain injury or TBI , @number@ plus or older adults , and assessment.
Search terms used included anthropology , culture , ethnic elderly and dementia.
Seasonal differences in serum osteocalcin , physical activity , and serum PTH were not statistically significant.
Seasonal mobilities bring about difficulties for retirees particularly in terms of their efforts to reconstruct their previous life and self-continuities.
Season of birth was not associated with any of the adult outcomes.
Sebaceous glands and hair follicles are important in the regeneration process of the dermis.
Sebaceous skin secretions along with daylight radiation cause the greatest perceivable color change to the silicone and pigment used in this study.
SEB was calculated by subtracting participants ' ratings of \ "Peer-Image \ " ( P ) from their ratings of Self-Image ( S ) .
Second , age-related declines in ProM with focal cues are larger in ProM proper and smaller in vigilance.
Second , analyses of variance tested associations between these distinct profiles and depressive symptoms.
Second , approaching the end , these processes may exhaust negative activation , prompting a terminal drop of NA close to death.
Second approach : @number@ SNPs were selected based on the overall genetic effect in exposed subjects ( p < 10-4 ) .
Second , are there similar atrophy rates within affected regions in AD ?
Secondarily , it examined their potential involvement in mediating inflammation and extracellular matrix degradation , the hallmarks of high-risk atherosclerotic unstable plaques.
Secondarily , the amount of food consumed on food intake assessments from foods on the FCI was analyzed.
Secondarily , the association between change in body mass and composition on change in several cardiometabolic risk factors and mobility was evaluated.
Secondarily , we assessed if varying cognitive demand resulted in decreased steadiness and was explained by anxiety or cortisol levels.
Secondarily , we stratified patients according to treatment with renin-angiotensin system ( RAS ) inhibitors.
Secondary aims pertain to intervention impact on HRQOL , physical function , and self-efficacy for managing fatigue.
Secondary aims were to assess other bone status indicators including bone turnover markers ( BTM ) and to define areas for future research.
Secondary aims were to consider whether the effects are independent of other measures of psychological functioning and how they may occur.
Secondary analyses considered time to loss of the ability to ambulate.
Secondary analyses examined additional outcomes : @number@ ) decline in @number@ cognitive subdomains and @number@ ) a global measure of the burden of AD pathology.
Secondary analyses examined eGFR using serum creatinine ( eGFR ( SCr ) ) .
Secondary analyses examining incident loss of the ability to ambulate revealed similar findings.
Secondary analyses were done within each cohort and across cohorts.
Secondary analysis of data from @number@ older adults from @number@ countries was completed.
Secondary carcinoma occurred in two cases.
Secondary : changes in medications.
Secondary client outcomes include changes in mental functioning , depressive symptoms , anxiety , and self-efficacy.
Secondary cognitive measures included set shifting and working memory.
Secondary conditions appear to be most commonly associated with severity of impairments.
Secondary cystectomy was performed in one patient.
Secondary dentine is responsible for a decrease in the volume of the dental pulp cavity with aging.
Secondary endpoints included BMD measurements and blood lipid profiles.
Secondary end points included Clarke Error Grid Analysis and alarm performance.
Secondary end points included clinical ( a composite of nonvertebral and symptomatic vertebral ) and nonvertebral fractures.
Secondary endpoints included investigator- and subject-assessed satisfaction and safety.
Secondary endpoints included physical performance , patient-reported outcomes , and immune markers of frailty measured at @number@ months postinfusion.
Secondary endpoints included recurrence rate , sustained clinical response ( clinical cure without recurrence ) , and time to diarrhea resolution.
Secondary endpoints included return of bowel function , pain scores , and changes in pulmonary function and quality of life.
Secondary endpoints included those focused on the safety and tolerability of prophylactic L-AMB.
Secondary endpoints were safety evaluation , performance duration , product handling , subjects ' and investigator's treatment evaluation.
Secondary endpoints were the amount of antibiotics used and bacteriologic response.
Secondary endpoint was in-hospital mortality.
Secondary goals examined albuminuria , age , race , sex , and metformin prescription.
Secondary hyperparathyroidism is a complex metabolic alteration secondary to chronic kidney disease ( CKD ) .
Secondary immunodeficiences are associated with an increased incidence of infection and malignancy , as well with development of autoimmune disease.
Secondary ion mass spectrometry ( SIMS ) imaging confirmed the presence of calcium phosphate in the spherules and identified cholesterol enrichment in their core.
Secondary measures included incidence and rate of hypoglycemia , and incidence of cardiovascular events.
Secondary measures included the Logical Memory test and changes in gray matter density.
Secondary measures were nutritional status and blood measurements.
Secondary objectives included an assessment of the product's effects on the appearance of rhytides and roughness.
Secondary objectives were microbiological outcome , duration of treatment and safety.
Secondary objectives were to evaluate the relationships between CFS and in-hospital complications and between admission FI-lab and discharge destination.
Secondary occlusion rate was low in both groups ( ≥70 years : @percent@ vs. < 70 years @percent@ ) .
Secondary osteoporosis is a consequence of an underlying cause and frequently is diagnosed after an atraumatic fracture.
Secondary osteoporosis is usually a result of a disease , such as cystic fibrosis , or medical treatment , such as corticosteroids or cancer treatment.
Secondary osteoporosis may be caused by various diseases and drugs , malnutrition , and other factors.
Secondary outcome measures have been selected to measure psychosocial , physical and mental health outcomes.
Secondary outcome measures included health parameters assessed with the RAI-HC ( Resident Assessment Instrument-Home Care ) .
Secondary outcome measures included renal failure and morbidity as defined within the postoperative morbidity survey.
Secondary outcome measures were ADL-dependency and pain documentation.
Secondary outcome measures were length of hospital stay and discharge destination.
Secondary outcome measures will be site-specific cancer incidence and mortality , respectively.
Secondary outcomes are : caregiver strain , all-cause readmissions , mortality , healthcare utilization , and medication adherence.
Secondary outcomes assess PA , physical performance , and anxiety / depression.
Secondary outcomes confirmed effects for strength and some , but not all , functional parameters.
SECONDARY OUTCOMES : handgrip strength , 8-m walk test , 4-step stairs test , Timed Up and Go test , and number of falls.
SECONDARY OUTCOMES : Impact of immune and metabolic markers.
Secondary outcomes include daily activity performance , fall self-efficacy , and health-related quality of life.
Secondary outcomes included a number of parameters for strength and function.
Secondary outcomes included appendicular lean mass , bone mass , biochemical bone markers , and physical function tests.
Secondary outcomes included association of normospermia , oligozoospermia , or azoospermia with biochemical or clinical hypoandrogenism.
Secondary outcomes included BMI , HbA1c , blood pressure and lipids.
Secondary outcomes included change in systolic blood pressure ( SBP ) .
Secondary outcomes included executive function , memory , and speed / attention tests , and cognitive domain scores.
Secondary outcomes included IGF-1 evaluated at baseline , @number@ and 6months.
Secondary outcomes included individual end points.
Secondary outcomes include discharge destination ; 30-day mortality , function and quality of life ; @number@ month readmissions ; and cost-effectiveness.
Secondary outcomes included length of stay , 90-day mortality and readmission , and CDI recurrence.
Secondary outcomes included measures of sensorimotor and daily functions.
Secondary outcomes include physical function and health-related quality of life.
Secondary outcomes include quality of life , healthcare utilization , and cost.
Secondary outcomes include skin aging analysis , telomere shortening in anesthetists.
Secondary outcomes of metabolic health included anthropometric measures and parameters of glucose metabolism.
SECONDARY OUTCOMES : other central haemodynamic variables.
Secondary outcomes were all-cause mortality , rehospitalizations , and hospital care costs.
Secondary outcomes were any , nonvertebral , and vertebral fractures.
Secondary outcomes were average daily step count for the @number@ days before the 2-month interview.
Secondary outcomes were behavior change , depressive symptoms , and alternate transportation use.
Secondary outcomes were BIS values , blood pressure , heart rate , respiratory rate , and body temperature.
Secondary outcomes were change in IPSS-quality of life score , maximum flow rate , average flow rate , voided volume , and post-voided volume.
Secondary outcomes were changes in staff adjustment.
Secondary outcomes were cognitive function ( Digits Forward , Montreal Cognitive Assessment , CLOX ) and physical function ( Barthel Index ) .
Secondary outcomes were contributing prognostic factors and impact of delirium.
Secondary outcomes were degree of frailty and use of municipal help services.
Secondary outcomes were dose and length of treatment and hospital stay , treatment complications , and 90-day mortality.
Secondary outcomes were institutionalization and mortality at 1-year follow-up , and logistic regression models were used to analyze these associations.
Secondary outcomes were lipid levels , blood pressure , health-related quality of life and symptoms of depression.
Secondary outcomes were not significantly different between the two groups.
Secondary outcomes were perceived fatigue , psychosocial work characteristics , work attitude , self-efficacy and work engagement.
Secondary outcomes were postoperative pain , opioid use , and length of hospital stay.
Secondary outcomes were qualitative assessments of specific methodology problems.
Secondary outcomes were the mortality rate , the respiratory rate , dyspnoea score , arterial blood gases.
Secondary outcomes were the total number of drug changes and the number of drug changes related to a recommendation.
Secondary outcomes will include the composite clinical events and major adverse cardiac events.
Secondary outcome was participation restrictions , which were defined as reductions / absence in valued social activities because of health.
Secondary POI implies surgical removal of ovaries , chemotherapy and radiotherapy , and infections.
Secondary predictors included QT duration as a continuous variable , a short QT interval , and QT intervals corrected by using other formulas.
Secondary prevention starts at the end of PPCI.
Secondary prevention strategies are aimed at reducing this risk.
Secondary sarcopenia should be considered when one or more other causes are evident , such as activity- , disease- , or nutrition-related sarcopenia.
Secondary sources of analyses were professionals ' insights ( obtained thought direct observation and interviews ) and statistics on the service.
Second , baseline level of PP predicted EM performance at centering age ( @number@ ) and rate of 9-year EM change.
Second , BrainAGE increased across at-risk , recent onset , and recurrent states of SZ.
Second , conventional methods do not clearly differentiate power due to rhythmic versus non-rhythmic activity.
Second , cross-sectional analyses from the same survey suggest that spiritual support is associated with volunteering in part because it promotes greater compassion.
Second , deciding to pass as opposed to gamble exerted more effort in inferior frontal and parietal areas only by 13- and 17-year-olds.
Second , Disease-disease network includes @number@ positively scored disease-disease relationships.
Second , do different genetic factors influence left and right hemisphere size in homologous regions ?
Second , effective treatment can be hampered by side effects of medications and complications from polypharmacy.
Second , fads and trends play a role in how the operation is taught and performed.
Second , FK-A11 is a pan-p110 isoform inhibitor.
Second-generation antihistamines and nasal glucocorticosteroids are also the first-line therapies in seniors.
Second-generation antipsychotics ( SGAs ) have been associated with an increased liability for weight gain and metabolic side effects.
Second , global aesthetic improvement score was used for assessment of the final cosmetic results.
Second , growth among the Hispanic population is outpacing both White and Black populations.
Second , H3.3 has been consistently associated with an active state of chromatin.
Second-hand smoke exposure and urban / rural residence had some impact among older groups.
Second , how old is the expansion ?
Second , I focus on the current efforts on developing various chemical approaches to targeting human telomeres and telomerase for the treatment of cancer.
Second , in a more therapeutically applicable approach , we administered ASOs targeting ataxin-2 to the central nervous system of TDP-43 transgenic mice.
Second , informal care externalities with spill-over into neighboring policy areas , the labor force , and formal LTC workers , should be properly addressed.
Second , in human studies , the data supporting cochlear synaptopathy are indirect although rapid progress has been made.
Second , interviews were conducted with eight social workers and nurses to uncover their perceptions about AD and their burnout experience.
Second , it was to compare precision errors and bone outcomes obtained with both methods within and between groups.
Second-line treatment should again be carefully selected.
Second , longevity statistics will be reviewed : Why do the most scientifically advanced countries have such low ( comparatively ) life expectancies ?
Second , low-executive OAs displayed white-matter deficits in the PFC , whereas low-memory OAs displayed white-matter deficits in the MTLs.
Secondly , adult lens structure and ultrastructure are covered , as well as the lens as a model for homeostasis and solute exchange.
Secondly , focus group discussions were conducted with @number@ purposively sampled students.
Secondly , SWDs may represent an independent risk factor for neuropsychiatric morbidities.
Secondly , those who improved their associative learning performance had a higher stereotypes score before the program.
Secondly , we considered the three phenotypes based on the definition of ageing , longevity and exceptional longevity and the associated biomarkers.
Secondly , we generated a human wild-type tau-overexpressing mouse.
Secondly , we generated probabilistic maps of the deep cerebellar nuclei in MNI space using a number of common normalization techniques.
Secondly , we review the systemic impacts of aneuploidy in cell physiology and emphasize how these include some of the primary hallmarks of aging.
Second , neurophysiologic output signals from complex brain connectivity might be characterized with multiple time scales or frequencies.
Second , @number@ families identified within the birth cohort had siblings discordant for autism.
Second , @number@ of @number@ dystonia subjects ( @percent@ ) exhibited an AI for position sense above the control group maximum.
Second , OCN undergoes physiological fluctuations during a lifetime.
Second , older age was associated with greater willingness to cancel the failing plan across all @number@ groups.
Second , participants were asked to recall memories from five life periods.
Second , personality traits that predicted subjective memory intercepts did not predict subjective memory slopes.
Second , pilot participants experienced statistically significant effects on mobility.
Second , prolonged exposure to chronic stress and environmental pollutants may play a critical role in decreasing fertility.
Second , ' Respect is a two-way street ' emphasises the need for reciprocal respect and recognition of history.
Second , respondents described the process of ' knowing your place ' within social hierarchies as a means through which they are rendered tolerable.
Second , RORα and CS modulated the expression of cell-cycle-regulating factors , such as p53 , p27 , and cyclin D in vSMCs.
Second , sex differences in ANP and BNP levels due to age were examined.
Second , simulated data and images of segmented T2-hypointensity were analyzed.
Second-stage analysis in an independent cohort further suggests the association of the 5q22.3 locus with circulating phylloquinone ( P < @number@ ) .
Second , such basic neural mechanisms of preparatory attention allocation seem preserved in healthy aging , despite impending sensory decline.
Second , that the lack of a corresponding increase in female reproductive lifespan reflects evolutionary constraint on late-life oocyte production.
Second , the authors examined whether baseline participation in lifestyle activities predicted differential @number@.5-year stabilities and transitions in cognitive status.
Second , the best fitting model was incorporated into a multi-group CFA model to test measurement invariance of the CES-D across the two population groups.
Second , the current care model is fundamentally detrimental to older women and women caregivers.
Second , the definition seems to treat SE as a characteristic of both the job and the individual at the same time.
Second , the deterioration of visual feedback and visuomotor integration in normal aging might have affected handwriting performance.
Second , the effect of each MS component on arterial stiffness may differ in relation to gender.
Second , the hearts of senescent animals are more susceptible to ischemia than those of young animals.
Second , the mechanisms underlying the neuroprotective , neurorestorative and stimulatory effects of NTFs on diseased neurons need to be defined.
Second , the molecular mechanisms through which insults might exert beneficial effects have thus far remained elusive.
Second , the observed improvement in CV function is attributed both to a reduction in CAA formation and a decrease in CAA-induced vasomotor impairment.
Second , the precipitating cause of the labro-acetabular damage must be addressed.
Second , there was an age-related reduction in the modulation of top-down coupling of the VLPFC on the hippocampus for episodically rich AMs.
Second , the same measurements were performed ex vivo on a second cohort , @number@ isolated , formalin fixed radii.
Second , these participants reported few specific ideas about how such health behaviors were important to their own brain health and cognition.
Second , these proteins carry a small charge and can be easily affected by the pH of the surrounding solution.
Second , the stability of individual ORF2 fusion proteins varies and difficult to predict.
Second , the tacit understandings which underpin the ' faith ' element of trust are difficult to explicate.
Second , they require a multidisciplinary approach.
Second , they were hospitalized in intensive care unit at our institution between @number@ and @number@
Second , this deficit extended to inconsistency , but less uniformly.
Second , three restrictions were identified that most readily form the basis of a graduated driving reduction program.
Second , to test for a causal link between SAT1 activity and PD histopathology , we investigated a mouse model expressing α-synuclein.
Second , two predicted yeast lifespan-extending genes , GRE3 and ADH2 , are experimentally validated , together with their associated hormetic effect.
Second type was characterized with significantly larger size , connective tissue content , and significantly lower cellularity , in relation to the first type.
Second , we analyzed different tensor mapping schemes for bone fabric prediction : identity , rotation-only , rotation and stretch tensor.
Second , we analyze the protective action of AMPK during fibrosis in myocardial , hepatic , renal , pulmonary , and other organs / tissues.
Second , we argue that wife sanctification contributes to widowers ' uncertainties about repartnering.
Second , we asked whether tactile-visual associations may be more pronounced in younger compared to older participants.
Second , we ask whether older adults have the same degree of flexibility to adjust the criterion in response to task demands as younger adults.
Second , we combined TDM-STF with the ordered subsets transmission ( OSTR ) algorithm for accelerating the convergence.
Second , we compared circulating inflammatory , antioxidant capacity , and vascular biomarkers between the groups.
Second , we concur that small things ( e.g. , transportation and medication management ) matter in big health systems.
Second , we constructed the bipartite miRNA-mRNA regulatory network by pair-wise correlation coefficient analysis between miRNA and mRNA expression profiles.
Second , we define relationships between dopamine , cognition , and frontoparietal activity in young adults indicating high levels of synthesis capacity are optimal.
Second , we described the effect of painful sites on disability during a 2-year follow-up period.
Second , we described the identified clusters with descriptive statistics and compared the clusters using analysis of variance ( ANOVA ) and chi-square tests.
Second , we discuss the pivotal role of Tfh in generation of antibody responses in HIV-infected persons in studies using influenza vaccines as a probe.
Second , we evaluated the effects of 25-OH oxysterol on apoptosis and pyroptosis hallmarks in keratinocytes.
Second , we examined the influence of an immediate retrieval attempt to minimize forgetting after the original encoding event.
Second , we examine the factors that contribute to health risks that the near-elderly face.
Second , we examine the relationship between major depression and cardiovascular disease and cancer , by baseline disease status.
Second , we explore autonomy and identify the tension between meaningful self-determination and prevailing ethical and legal norms associated with informed choice.
Second , we explore the underlying neurobiological mechanisms that may account for these human sleep alterations.
Second , we gathered evidence on effective health systems interventions in low- middle- and high-income countries.
Second , we generated retrospective standardized clinical data from patients with autopsy-confirmed PSP and control diseases.
Second , we hypothesized that differences in directional connectivity are associated with differences in religiosity.
Second , we hypothesize that after reproductive life , there was selection for organisms that contribute to host demise.
Second , we observed a significant indirect effect of social activity on all domains of cognitive function through cognitive activity at the between-person level.
Second , we present evidence in support of a chronic disease model of AD that informs our choice of phenotypes as the target outcome.
Second , we recommend a stronger orientation towards processes in order to study health behaviors and the design of health-behavior change interventions.
Second , we should assess the degree of functional reserve of specific , pertinent organ systems.
Second , we suggest that the process of healthy aging involves an adjustment of personal development that should never stop.
Second , we tested the effects of aerobic exercise training on plasma Klotho concentrations and arterial stiffness.
Second , we used the extracted five factors as predictors in regression models predicting the incidence of falls over a 12-month prospective observation period.
Second , we used the Norwegian Patient Registry ( NPR ) to estimate the proportion of the population who used specialist health services in @number@
Second , we use the optical fractionator to estimate pyramidal neuron number and the nucleator for pyramidal somal and nuclear volume.
Second , we were unable to include potential confounders such as medical comorbidities , smoking status , or environmental exposures.
Second , we will explore fundamental differences in individual PDE4 subtypes , and then begin to address differences between pathological and non-pathological aging.
Second , we will highlight outcome after transplantation from elderly donors.
Second , what are the emergent patterns of functionally adapted trait sets in long bones ?
Second , what role does gender play in understanding race differences ?
Second , whereas a large variation in CL affected WM performance , a small CL manipulation had no effect on the elderly.
Second , with increasing age , ETI was less strongly correlated with functioning whereas ETW was more strongly correlated with it.
Secreted Klotho functions as a humoral factor that inhibits AKI , vascular calcification , renal fibrosis , and cancer metastasis in an FGF23-independent manner.
Secreted proteins in media were analyzed by multiplex protein analysis after 48-hour exposure at culture day @number@
Secreted TNF- α level were determined using specific enzyme-linked immunosorbent assay kits.
Secretion by the choroid plexus is characterized by an extremely high rate and by the unusual cellular polarization of well-known epithelial transport proteins.
Secretion of extracellular matrix proteins is arrested in chondrocytes and causes skeletal malformation and chondrodysplasia.
Secretion of growth hormone ( GH ) and IGF-1 levels decline during advancing years-of-life.
Secretion of stress hormones ( CORT and 5HT ) is under the control of the circadian clock in the suprachiasmatic nucleus.
Secretion of these exosomes requires neutral sphingomyelinase @number@ and sphingolipid synthesis.
Secretion parameters were quantified by automated deconvolution , approximate entropy [ ApEn ] , spikiness , and diurnal properties.
Section detachment in immunohistochemistry ( IHC ) is a common phenomenon , increasing times and costs of diagnosis and research.
Sections from regions of interest ( ROI ) on post-mortem examination were studied.
Sections of disk immunostained for MMP-1 and TIMP-1 were evaluated semiquantitatively.
Sections of retina tissue stained by hematoxylin and eosin ( H & E ) and immunohistochemistry were analyzed.
Sections of skin , adipose tissue , and muscle were harvested from each of @number@ cadavers.
Sections positive for hTERT expression showed nuclear and some nucleolar staining in cells of the basal and suprabasal layers.
Sections ( thickness @number@ mm ) of each sample were taken and stained with hematoxylin-eosin and Verhoeff-Van Gieson stains.
Sections were stained with Masson-Goldner and Cresyl-violet dyes.
Secular change in adult height of residents in a rural indigenous community in the Valley of Oaxaca was evaluated.
Secular changes and intra-individual differences in body shape and size can confound cross-sectional studies of muscle ageing.
Secular effects of age were assessed by comparing @number@ younger and @number@ older women.
Secular increase in height occurred but estimated rates varied over time and between sexes.
Secular increases favoring later-born cohorts in fluid intelligence measures are widely documented for young adults.
Secular trends and correlations with changes in national income were examined.
Secular trends appear to modify age-related trajectories of cardiovascular risk factors , which may be a source of bias in longitudinal analyses.
Secure identification of those patients is mandatory to avoid complications with harmful long-term effects.
Sedative drug use was at @percent@ for frail , @percent@ for prefrail , and @percent@ for nonfrail participants.
Sedentary aging leads to increased cardiovascular stiffening , which can be ameliorated by sufficient amounts of lifelong exercise training.
Sedentary aging results in a diminished rapid cutaneous vasodilator response to local heating.
Sedentary and pre-frail , but not active , men displayed lower mitochondrial content irrespective of fibre type vs. YA.
Sedentary behavior averaged @number@ hr / day for the NYC sample and @number@ hr / day for the NHANES sample.
Sedentary behavior should be viewed as a distinct health behavior ; therefore , its determinants should be independently identified.
Sedentary behaviors ( involving prolonged sitting ) can be associated detrimentally with health outcomes.
Sedentary behaviour ( SB ) has recently emerged as an independent risk factor for different health outcomes.
Sedentary time and physical activity of light and moderate to vigorous ( mod / vig ) intensity was measured using an accelerometer.
Sedentary time during waking hours was measured by an accelerometer ( < 100 counts per minute ) .
Sedentary time was objectively measured with devices ( accelerometers ) and using self-reports.
See all the articles in this CEBP Focus section , \ "Biomarkers , Biospecimens , and New Technologies in Molecular Epidemiology. \ "
Seeding activity correlated positively with Braak stage and negatively with MMSE.
Seed longevity is important to preserve crops and wild plants and it is limited by progressive cellular damage ( aging ) during storage.
See Guidelines for Authors for a complete description of levels of evidence.
Seeing how their close relative cared for a dependent older adult led them to reflect on what they would become in the future.
Seeing patients in the community , time spent being taught by a GP and seeing patients with a GP were particularly well received.
See Instructions for Authors for a complete description of levels of evidence.
See Instructions for Authors for a complete description of levels of evidence.
See Instructions for Authors for a complete description of levels of evidence.
Seeking an insider's perspective , the study employed an ethnographic research design.
Seeking care for BP increased from @percent@ and @percent@ at the two youngest ages to @percent@ at the oldest.
Seeking support was unrelated to work ability.
SEER-Medicare data ( 1991-2009 ) were used to identify beneficiaries who underwent total thyroidectomy for WDTC.
SEER-Medicare-linked database ( @number@ white men and women aged ≥ @number@ with invasive melanoma [ regional and distant stages ] ; 1991-1999 ) was used.
See Stayte and Vissel ( doi : 10.1093 / awx064 ) for a scientific commentary on this article.
See the Guidelines for Authors for a complete description of levels of evidence.
See Vandenberghe and Schaeverbeke ( doi : 10.1093 / awx065 ) for a scientific commentary on this article.
Segmental bioelectrical impedance spectroscopy is a unique tool with which to assess intracellular and extracellular water in the limbs.
Segmental bioelectrical impedance spectroscopy would be useful for the assessment of skeletal muscle cell mass and sarcopenia in the elderly.
Segmental displacement and bilateral tibialis anterior and gastrocnemius muscle EMG responses were recorded.
Segmental lordosis at L4-L5 increased @percent@ and global lordosis increased @percent@.
Segmental motion tended to decrease in the most severe grade , with a significant difference in angular mobility.
Segmental progeroid syndromes are a group of disorders with multiple features resembling accelerated aging.
Segmental SFBIA and MFBIA were measured for the upper legs.
Segmentation of hippocampal subfields was performed using FreeSurfer.
Segmentation times were compared to results from two examiners who visually segmented the activities.
Segmentation was accomplished by identifying the first minimum or maximum to the right and the left of these peaks.
Segmentation was performed in the medial central ( weight-bearing ) femur and tibia to determine cartilage proteoglycan concentration and thickness.
Segregation was possible only for @number@ variant ( p.E462delInsGK ) that was found in @number@ affected siblings.
SE had an uneven involution , both individually and inter-individually , but with normal spermatogenesis in many of ST.
Se is an essential trace element for the biosynthesis of enzymatically-active selenoproteins , protecting the organism from oxidative damage.
Seizure-related injuries were noted in four out of seven patients and may have been a motivation to proceed with RES in our cohort.
Seizures have variable effects on brain.
Seizures were prominent in the other typical APP duplications.
Seizure threshold was titrated at the first ECT session.
Seladin-1 was considered a novel neuroprotective factor , because of its anti-apoptotic activity.
Selected articles are critically reviewed and summarized.
Selected formulations delivered into periodontal pocket evaluated clinically showed to be effective.
Selected HRR and HRV ( time-domain ) parameters , but not arterial stiffness were significantly reduced in adults after ToF repair.
Selected indices of glucose homeostasis were defined using fasting glucose and insulin data.
Selected instruments were evaluated and scored for scientific soundness and potential application in clinical quality measurement.
Selected interventions may help to improve the quality of prescriptions and reduce the burden of underprescribing.
Selected items can comprehensively and properly assess the fall risk of the healthy elderly as compared with existing questionnaires.
Selected medical conditions not associated with the heroin-use lifestyle ( i.e. , hypertension , diabetes , arthritis ) were lower relative to the comparison samples.
Selected non-peer reviewed literature such as government reports and unpublished academic dissertations were also reviewed.
Selected patients aged @number@ and older have a chance of treatment with pegylated interferon plus ribavirin , despite a higher likelihood of side effects.
Selected patients underwent a second-level evaluation.
Selected Reaction Monitoring ( SRM ) is a powerful tool for targeted detection and quantification of peptides in complex matrices.
Selected registered dietitians from the Ontario Long-Term Care Action Group also participated ( n = 5 ) .
Selected studies were assessed for methodological quality and data pooled and meta-analysed.
Selected variables from the first three examinations ( 1965-1968 ; 1968-1970 ; 1971-1974 ) were used to identify potential candidate GBM risk factors.
Select gait parameters were examined while individuals walked at their preferred speed across the GAITRite electronic walkway.
Selecting an appropriate donor is vital to the success of FMT.
Selecting appropriate candidates for surgical resection is therefore crucial to maximize the benefit derived from surgery.
Selection bias may also contribute to cross-study heterogeneity.
Selection criteria included community dwelling populations aged @number@ years and over and publications written in English.
SELECTION CRITERIA : Randomized trials in the English language with placebo and / or active arms with a duration of at least @number@ months.
SELECTION CRITERIA : The outcomes observed were : fetal and perinatal survival , preterm birth and abnormal neurological outcome.
Selection criteria ultimately focused on use of workstation alternatives during simulated or real work tasks.
SELECTION CRITERIA : We included randomized controlled trials ( RCTs ) and quasi-RCTs with or without blinding involving people with mRCC.
SELECTION CRITERIA : We planned to include randomized or quasi-randomised controlled trials where NAC was compared to control in people with age-related cataract.
Selection of appropriate antiepileptic drugs ( AEDs ) for this group of patient also requires more attention than younger patients.
Selection of persons at risk is a first crucial step in this process.
Selection of T cells does not end with events in the thymus , but continues in extrathymic tissues and for the life of the organism.
Selection pressure analysis using PAML program revealed that MRPS5 and PPARGC1A were under significant constraints because of their functional significance.
Selective attention , an essential part of daily activity , is often impaired in people with Alzheimer's disease ( AD ) .
Selective attention biases the encoding and maintenance of representations in visual STM ( VSTM ) .
Selective attention involves top-down modulation of sensory cortical areas , such that responses to relevant information are enhanced whereas responses to irrelevant information are suppressed.
Selective attention requires the ability to focus on relevant information and to ignore irrelevant information.
Selective attrition due to death and institutionalization is substantial over @number@ years.
Selective breakdown of brain networks during progression from normal aging to Alzheimer disease dementia ( AD ) has also been observed.
Selective contrast radiography was done using direct injection of double-contrast medium consisting of 20-100 mL of @percent@ gastrografin and 50-200 mL of air.
Selective engulfment of mitochondrial profiles into autophagic vacuoles is common in young-adult odontoblasts , suggesting a microautophagic pathway.
Selective infiltration etching is a new surface treatment that enhances bonding to zirconia-based materials.
Selective macroautophagy is an important protective mechanism against diverse cellular stresses.
Selective mutism occurred early , when general neurologic examination only showed mild decrease in finger dexterity in the right hand.
Selective neck dissection was applied in recurrent cases to extirpate branchial lesions , scarrings and inflammatory granuloma.
Selective protein oxidation may cause protein damage , or protein mutations may induce a dysfunction of the proteasome.
Selective removal of mitochondria by autophagy ( termed mitophagy ) has been extensively studied recently in both yeast and mammalian cells.
Selective ROCK2 inhibition with a small molecule decreased M2-like macrophages and choroidal neovascularization.
Selective serotonin reuptake inhibitors were most frequently prescribed.
Selective survival could possibly explain the lack of association between social adversity and hsCRP in the Latin American samples.
Selective survival may also play a role.
Selective violation of expectations can add to aesthetic response but radical or frequent violations are likely to be disliked or not comprehended.
Select reserve markers attenuate the risk of delirium associated with lower grade inflammatory processes , supporting the role of reserve in delirium.
Selenium is an essential trace element , which is incorporated as selenocysteine into at least @number@ selenoproteins using a unique translational UGA-recoding mechanism.
Selenium levels decline during aging , and its deficiency is associated with a marked increase in mortality for people over @number@ years of age.
Selenium levels regulate the entry into replicative senescence and modify the cellular markers characteristic for senescent cells.
Selenium levels were unchanged with aging.
Selenium protects keratinocyte stem cells ( KSCs ) against senescence via preservation of their stemness phenotype through adhesion to the basement membrane.
Selenium ( Se ) is an essential nutrient for human beings , with serious consequences resulting from clinical deficiency.
Selenoprotein forms of Msrs containing selenocysteine ( Sec ) at the catalytic site are found in bacteria , algae , and animals.
Selenoprotein P ( SELENOP ) is a liver-derived transporter of selenium ( Se ) in blood , and a meaningful biomarker of Se status.
Selenoproteins are important enzymes involved in antioxidant defense , redox homeostasis , and redox signaling pathways.
SELENOP was affinity-purified and its Se content was determined from a subset of samples.
Self-assessed hearing and tinnitus was mainly unchanged , or had minor changes both to the better and to the worse.
Self-assessment and self-satisfaction with glabellar line improvement were also evaluated.
Self-assessment of driving ability in older drivers provides useful information to raise awareness of their driving performance.
Self-assessment questionnaires , biomechanical measurements , and adverse events ( AEs ) were analyzed.
Self-association of amyloidogenic proteins is the main pathological trigger in a wide variety of neurodegenerative disorders.
Self-attack by the complement system can occur whenever it fails to do so.
Self-care may be neglected , resulting in hospitalization.
Self-comparative self-rated health was not associated with higher mortality.
Self complaint was related inconsistently to diagnostic outcome.
Self-efficacy and perceived norms were the most important factors predicting intent to communicate for this sample of women.
Self-efficacy , executive functioning , working memory , processing speed , episodic memory , and vocabulary were assessed with the NIH Toolbox.
Self-efficacy explained @percent@ of the variance in fallers ( P < @number@ ) and @percent@ in nonfallers ( P < @number@ ) .
Self-efficacy for neighborhood barriers trended toward significance in fallers ( β = @number@ P = @number@ ) .
Self-efficacy was also independently associated with physical performance and muscle strength.
Self-efficacy was independently-associated with self-care adherence ( P = @number@ ) .
Self-enhancement values were measured using the Norwegian Life Course , Generations and Gender Study beginning in @number@
Self-esteem is linked to high-risk behaviors in other populations but has not been examined in women aged @number@ and older.
Self-esteem partially mediated the association between rape and psychological functioning , but not health functioning.
Self-evaluation of @number@ patients using a 9-point rating scale after application of RF treatment also showed improving satisfaction ( p < @number@ ) .
Self-injurious behavior ( SIB ) is a distressing type of problem behavior that may be exhibited in individuals with intellectual disabilities ( IDs ) .
Self-limiting AF was defined as < 7 days ' duration.
Self-management ability and medication management support were predictors of medication management capacity.
Self-management ability and medication management support were significantly associated with medication management capacity.
Self-management of chronic conditions by older adults is a public health priority.
Self-management policies are part of a shift from patient rights to individual responsibilities , a shift that may be less persuasive than its supporters imagine.
Self-management was commonly negotiated alongside multimorbidities.
Self-perceived poor health and prior nursing-home admission were marginally significant.
Self-perceived risk of falling was assessed through four questions.
Self-perceived worsened health was positively associated with overall EA ( odds ratio [ OR ] @number@ ( @number@ @number@ ) .
Self-perceptions of aging were measured by the Attitudes to Aging Questionnaire.
Self-rated depression symptoms were measured using HADS-D , the scale of self-administered depression symptoms in HADS ( Hospital Anxiety and Depression Scale ) .
Self-rated disability and aspects of health-related quality of life explained additional @percent@.
Self-rated health appeared to improve over time , and the extent of this improvement was also related to executive functioning at baseline.
Self-rated health decreased in both groups of older people with a growing number of diseases.
Self-rated health , extraversion , and openness to experience were associated with a younger subjective age at older ages.
Self-rated health is a frequently used measure , notably in the field of gerontology.
Self-rated health ( SRH ) was measured by WHO-Europe recommended version ( ranging from ' very good ' to ' very bad' ) .
Self-rated health was dichotomized into very good / pretty good and not too good / poor / very poor.
Self-rated health was obtained from the SF-12.
Self-rated physical and mental health and personal mastery are associated with SAP and vary in different age groups.
Self-rated physical and mental health indicators were obtained at both occasions.
Self-rated physical and mental health were measured by two items from the International Classification of Functioning , Disability and Health checklist.
Self-rated quality of life measure also showed improvements alongside the cognitive benefits.
Self-Rating Scale of Memory Functions was used as a questionnaire subjective measure.
Self-referencing has been identified as an advantageous mnemonic strategy for young and older adults.
Self-regulation failures can arise from any of these factors , and the resulting implications for obesity should be considered in light of each domain.
Self-report and physical examination assessed anthropometric , sociodemographic and lifestyle factors.
Self-report cognitive effort scales have been developed , but objective measures are lacking.
Self-report depression scales were administered at baseline and end of acute treatment.
Self-reported 12-month usage patterns of CAM , AH , and MT were determined by mailed questionnaire.
Self-reported and objective measures of physical and mental health data and demographic information were collected for all participants.
Self-reported anger and hostility was higher for the exploited group.
Self-reported appetite in the past week was classified as ' good ' or ' poor ' using a validated instrument.
Self-reported back pain occurring in the past @number@ days was the outcome.
Self-reported balance tended to be associated with an objective assessment of vestibulo-ocular reflex in this population of older adults.
Self-reported circumference measures appeared to be more accurate than the derived WHR.
Self-reported current and maintained HEPA increased.
Self-reported current psychological distress did not affect telomere length.
Self-reported daily stressors and CAR moderated the relationship of cognitive decline and memory problems.
Self-reported daily TV viewing was measured at baseline and @number@ years follow up.
Self-reported data included current ( past week ) and maintained ( past @number@ months ) HEPA levels , sociodemographics and disease-related and psychosocial factors.
Self-reported data on health , life-style , and medication were used to adjust the multivariate linear regression models.
Self-reported data were verified by third parties when feasible.
Self-reported discrimination is significantly and positively associated with depressive symptoms , independent of sociodemographic characteristics , migration-related variables , and personality factors.
Self-reported discrimination was assessed by the Experiences of Discrimination instrument and was dichotomized ( yes vs no ) .
Self-reported emotion regulation measures were completed prior to the session.
Self-reported endoscopies were validated by medical records.
Self-reported glaucoma is ∼2.4 times more common than what the prevalence estimates suggest.
Self-reported health and lifestyle questions were administered as part of a wider sexual health interview.
Self-reported hearing difficulty was also associated with higher odds for mental health service use ( OR = @number@ @number@ % CI @number@.2-3.5 ) .
Self-reported histories of glaucoma and the use of drops to lower eye pressure were obtained at follow-up examinations ( 2014-2016 ) .
Self-reported HIV status and dried bloodspots for HIV biomarker testing were obtained during at-home interviews.
Self-reported IADLs were assessed at baseline and follow-up.
Self-reported information on colonoscopies and their indications was validated by medical records.
Self-reported IPAQ MVPA levels were adjusted using an equation derived from a previous validation study.
Self-reported measures included sociocultural characteristics , acculturation , cognitive function , family network , utilization of ADHC , and QOL.
Self-reported mobility disability on three tasks was assessed : walking up stairs , walking down stairs , and walking @number@ feet.
Self-reported number of teeth was classified as an inadequate dentition if less than twenty-one teeth were present.
Self-reported olfaction was assessed with a 5-point Likert scale.
Self-reported olfactory function has poor sensitivity ( i.e. , people with measured olfactory dysfunction are unlikely to accurately report it ) .
Self-reported PA was reported at baseline through year @number@
Self-reported physical activity was assessed at baseline ( 2002-2003 ) and through follow-up.
Self-reported prospective memory was correlated with informant report only in the dementia group , not in the control or MCI groups.
Self-reported restriction was prevalent in this cross-sectional sample ( @percent@ ) and was related to DriveSafe scores and personal circumstances but not DriveAware scores.
Self-reported rhinoconjunctivitis also correlated with urbanization.
Self-reported scores for energy and concentration were significantly greater.
Self-reported sedentary behavior was related to better performance on one cognitive task ( trails A ; p < @number@ ) .
Self-reported sedentary time was assessed by questionnaire and examined in @number@ categories ( ≤4 , > 4-8 , ≥8-11 , > 11 hours ) .
Self-reported sitting time ( < 4 or ≥4 h / day ) was the main outcome.
Self-reported sitting time , gait speed , and depressive symptoms also improved ( all p values < @number@ ) .
Self-reported sleep duration and anthropometric data were collected.
Self-reported sleep duration and sleep problems were also not associated with cortisol.
Self-reported sleepiness scores are similar to those of patients who have been diagnosed with sleep disturbances.
Self-reported sleep quality was also assessed using the Pittsburgh Sleep Quality Index.
Self-reported smoking , alcohol consumption , exercise and fruit intake at baseline is also available.
Self-reported supplementary intake of calcium was aggregated and divided into quintiles.
Self-reported visual impairment was present almost @percent@ of the sample.
Self-reported weight loss or gain and causes were measured during a personal interview.
Self-reporting questionnaires were used , followed by descriptive statistics and multiple regressions as inferential statistical analyses.
Self-report , interview and physical assessment were the data collection methods used.
Self-report is the gold standard for assessing pain ; however , in many clinical circumstances with older adults , the patient's verbal report is unobtainable.
Self-report measures of pain , anxiety , and tension were administered , and facial expressions , heart rate , and galvanic skin response were recorded.
Self-report of SB is lower , with average weighted self-reports being @number@ hr daily.
Self-reports of victimization of relational aggression were related to depression , anxiety , satisfaction with life and social loneliness , but not to emotional loneliness.
Self-reports were characterized by low sensitivity ( @percent@ ) , but high specificity ( @percent@ ) .
Sema5A is strongly expressed by GCs and regulates dendritic spine density in a cell-autonomous manner.
Sema5A- / - mice display deficits in social interaction , a hallmark of
Sema5A signals through PlexinA2 co-expressed by GCs , and the PlexinA2-RasGAP activity is necessary to suppress spinogenesis.
SEM analysis showed that specimens submitted to WS or ML showed features of degradation and fatigue at the fractured interface , depending on the adhesive.
SEM and AFM analyses showed dislodgement of ZrO BACKGROUND : Bradykinesia and reduced neuromuscular force exist in Parkinson disease.
Semantic and working memory changes from baseline were significant with DHA but no between group differences were detected.
Semantic memory and naming have also been found to be affected , although to a lesser degree than episodic memory.
Semantic variant patients had relatively reduced activation of caudate and anterior cingulate in response to increased entropy.
Sembragiline showed potent and long-lasting MAO-B-selective inhibition and did not inhibit MAO-A at doses where full inhibition of MAO-B was observed.
SEM demonstrated patterns of clot dissolution among various treatment modalities.
SEM examination revealed that all specimens failed cohesively by fracture of the supporting tooth.
SEMG was recorded bilaterally from the L1 ( iliocostalis lumborum ) , L2 ( longissimus ) , and L5 ( multifidus ) recording sites.
Semi-automated segmentation allowed extracting parietal thickness and lumen diameter.
Seminal events compounded by a sense of things being different triggered awareness of mealtime changes.
Seminal works , which were frequently cited in journal articles , were also reviewed.
Semiological , EEG , and 3-channel EKG features were studied.
Semiparametric ( ie , discrete ) group-based mixture modeling identified the trajectories , and multinomial logistic regression identified risk factors for differential trajectory groups.
Semistructured focus groups asked what activities best prepared the participants for decision making.
Semistructured , in-depth interviews were conducted in 2008-2009 , and transcripts of data were subjected to Morse's content analysis method.
Semistructured interviews and document reviews were used in the data-collection process.
Semistructured interviews explored the nature of the foot problem , help-seeking behaviors , and consultation experiences.
Semistructured interviews were administered , transcribed , and meaningful phrases extracted from transcripts.
Semi-structured interviews were analyzed using a qualitative description approach.
Semi-structured interviews were carried out with @number@ residents.
Semi-structured interviews were conducted.
Semistructured interviews were conducted and data were analyzed using within- and cross-case analysis.
Semi-structured interviews were conducted on the timeline of acquirements , and people and factors involved in acquirements.
Semi-structured interviews were conducted with @number@ adults aged 69-94.
Semi-structured interviews were conducted with @number@ family members who had recently been involved in a nursing home to hospital transfer decision.
Semistructured interviews were conducted with @number@ students and with @number@ older adults who participated in the programme.
Semi-structured interviews were performed with @number@ functionally independent aged individuals from João Pessoa , Paraiba , Brazil.
Semi-structured interviews with @number@ Chinese ageing males with moderate-to-severe LUTS were conducted.
Semistructured interviews yielded data that were analyzed qualitatively , using McCracken's five-step process for analysis.
Semi-structured questions prompted discussion on nurses ' perspectives , needs and strategies to meet their needs.
Semi-supercentenarians , or people who reach @number@ years of age , are regarded as model cases for ' successful ageing'.
SEM produced good fit indexes that supported the Work Ability Model.
SEM revealed tau as the most salient RT index associated with neuropsychological measures of executive functioning.
SENEB thickness was not changed.
Senescence-accelerated resistant animals showed no significant changes with age.
Senescence acts as a homeostatic mechanism that can even limit renal fibrosis , at least in animal studies.
Senescence-Associated β-Galactosidase ( SA-β-G ) expression in the three groups was examined using β-galactosidase staining working solution.
Senescence can be triggered by different stress stimuli , such as DNA damage or oncogene activation.
Senescence , defined as irreversible cell-cycle arrest , is the main driving force of aging and age-related diseases.
Senescence evolved as a beneficial response to damage promoting wound healing , limiting fibrosis , fighting against cancer and helping embryonic development.
Senescence is a cell state occurring in vitro and in vivo after successive replication cycles and / or upon exposition to various stressors.
Senescence is a cellular process that is thought to have prognostic and therapeutic relevance in conditions such as cancer , aging , and fibrosis.
Senescence is a cellular response to damage and stress.
Senescence is a form of cell-cycle arrest linked to tumor suppression and aging.
Senescence is a form of cellular aging that limits the proliferative capacity of cells.
Senescence is a highly regulated process that limits cellular replication by enforcing a G1 arrest in response to various stimuli.
Senescence is also recognized as a mechanism for limiting the regenerative potential of stem cells and to protect cells from cancer development.
Senescence is a permanent cell cycle arrest that is accompanied by changes in cell morphology and physiology occurring in vitro and in vivo.
Senescence is a phenomenon characterized by a progressive decline of body homeostasis.
Senescence is a stable proliferation arrest , associated with an altered secretory pathway , thought to promote tumor suppression and tissue aging.
Senescence is characterized by a breakdown of immunological self-tolerance , resulting in increased reactivity to self-antigens.
Senescence is one of the hallmarks of aging and identified as a potential therapeutic target in the treatment of aging and aging-related diseases.
Senescence marker protein-30 ( SMP-30 ) , which is a protein that is remarkably reduced upon aging , was used as a senescence marker.
Senescence markers and prelamin A were also observed in PBMCs from HIV-infected patients under ritonavir-boosted PIs.
Senescence markers were evaluated in peripheral blood mononuclear cells ( PBMCs ) from HIV-infected patients under PI treatment.
Senescence markers were lower in PBMCs from PI-treated patients cotreated with statins.
Senescence occurs when p53 fails to inhibit mTOR.
Senescence of vascular smooth muscle cells ( VSMCs ) contributes to aging as well as age-related diseases of the cardiovascular system.
Senescence provides an early barrier against tumor development by preventing proliferation of cells with damaged DNA.
Senescence secretome was recently reported to promote liver cancer in an obese mouse model.
Senescence was confirmed by cytochemical staining for a panel of markers including Ki67 , p21 , heterochromatin protein 1β , and activity.
Senescence was evaluated by calculating the percentage of amniocytes with fragmented nuclei : senescence associated heterochromatin foci ( SAHF ) , using DAPI staining.
Senescence was quantified by staining with senescence-associated β-galactosidase and by evaluating western blots probed for phosphorylation of mitogen-activated kinases.
Senescent animals show over-responsiveness to αMSH , the major anorexigenic neuropeptide.
Senescent cell accumulation in aging tissues is linked to age-associated diseases and declining function , prompting efforts to eliminate them.
Senescent cell-induced MYC silenced its target gene CFLAR , encoding the apoptosis inhibitor FLIPL , thus leading to the acquisition of TRAIL sensitivity.
Senescent cells accumulate during aging and have been implicated in promoting a variety of age-related diseases.
Senescent cells accumulate in tissues of aged animals and deteriorate tissue functions.
Senescent cells accumulate with age in a variety of human tissues where they develop a complex senescence-associated secretory phenotype ( SASP ) .
Senescent cells accumulate with age in tissues and are suspected to play a role in age-associated diseases.
Senescent cells accumulate with aging and at sites of pathology in multiple chronic diseases.
Senescent cells acquire a proinflammatory senescence-associated secretory phenotype.
Senescent cells acquire the ' senescence-associated secretory phenotype' , which promotes and sustains tissue inflammation.
Senescent cells are characterized by several features including increased activity of senescence-associated β-galactosidase ( SA-β-GAL ) and senescenceassociated secretory phenotype ( SASP ) .
Senescent cells are present in premalignant lesions and sites of tissue damage and accumulate in tissues with age.
Senescent cells are thought to impair tissue function , and their genetic clearance can delay features of aging.
Senescent cells develop a pro-inflammatory response termed the senescence-associated secretory phenotype ( SASP ) .
Senescent cells exhibit altered expression of numerous genes.
Senescent cells have been identified in many tissues and organs , including the kidney.
Senescent cells increase in number with age in most , if not all , mammalian tissues , including the airways and lungs.
Senescent cells influence many biological processes , including embryonic development , tissue repair and regeneration , tumor suppression , and aging.
Senescent cells observed in the area of chronic wounds have been proposed to affect wound healing.
Senescent cells secrete a plethora of factors with potent paracrine signaling capacity.
Senescent cells showed a reduced tolerance to oxidative stress.
Senescent cells were detected in murine , primate and human tissues using different markers.
Senescent chondrocytes are found in cartilage tissue isolated from patients undergoing joint replacement surgery , yet their role in disease pathogenesis is unknown.
Senescent EC populations were defined by increases in β-galactosidase activity and p16 levels.
Senescent ECs also displayed lower Jagged1 expression compared to young ECs , which was more evident after H₂O₂ stimulation.
Senescent endothelial cells ( EC ) have been identified in cardiovascular disease , in angiogenic tumour associated vessels and in aged individuals.
Senescent individuals may benefit from such a combination.
Senescent VSMCs have been shown to be present in atherosclerotic plaques.
Senile amyloid plaques are one of the diagnostic hallmarks of Alzheimer's disease ( AD ) .
Senile plaque and NFTs are formed by accumulation of amyloid-β ( Aβ ) and hyperphosphorylated tau , respectively.
Senior and senile age is characterized by psychological , social and somatic heterogeneity of patients.
Senior centers are interested in participating in research that provides benefit to older adults but may need assistance from researchers to overcome participation barriers.
Senior centers , health care organizations , and residential facilities served @percent@ of the participants.
Senior citizens are at an increased risk of developing chronic conditions , which in turn increase discomfort associated with physiological processes of aging.
Senior citizens are trained as paraprofessionals to deliver the BA module to increase the potential for sustainability of the program.
Senior citizens can improve their control beliefs and develop self-regulation and coping skills.
Senior citizens who have difficulties using new media run the risk of exclusion in today's information society.
Senior fitness test manual.
Senior groups showed increased negative priming in reaction times.
Senior populations represent a substantial percentage of Salmonella-related hospitalizations and deaths in Canada and the burden associated with those hospitalizations is also greater.
Seniors completed a sustained attention task and self-reported their current attentional states.
Seniors intended to use information in the educational tool to stimulate discussions about falls with health care providers.
Seniors ' online communities provided a unique form of casual leisure , whose nature varied among different groups of participants.
Seniors vs. young participants showed longer reaction times and higher skin conductance response ( SCR ) during swallowing.
Seniors with a higher 25 ( OH ) D status also had better cognitive function ( MMSE score ; p = @number@ ) .
Seniors with decreased postural control showed higher TA contributions during SLEO.
Seniors with reduced executive functioning-such as senior fallers-may be prone to poor mobility judgments , especially under dual-task conditions.
Senior wellness fairs ( SWFs ) offer a unique opportunity for community health promotion and interprofessional education ( IPE ) .
Senolytic agents are being tested in proof-of-concept clinical trials.
Senolytic drugs are agents that selectively induce apoptosis of senescent cells.
Sensations of pain have a particular influence on the mentioned discomfort , and pain is prevalent among older people.
Sense of coherence , the coping strategy Acceptance , neuropathic pain and leisure-time physical activity explained @percent@ of the variance in depressive symptoms.
Sense of coherence was found to be the surrogate term.
Sense of control is an important self-regulatory resource that drives cognitive and physical health over the lifespan.
Sense of control ( @percent@ ) and perceived cohesion ( @percent@ ) contributed to low SRH.
Sense of mastery emerged as a major ( negative ) predictor and as a mediator between caregiving burden and depressive symptoms.
Sensing of DNA lesions initiates a highly complex DNA damage response ( DDR ) .
Sensitive communication and a person-centred approach are essential.
Sensitive diagnostic tests now demonstrate that healthy urinary tracts host a ubiquitous , complex microbial community.
Sensitive magnetic resonance imaging procedures , such as gradient-echo T2 imaging and susceptibility-weighted images , are useful to detect microhemorrhagic lesions.
Sensitivities and specificities of A1c compared with FPG were @number@ and @percent@ for diabetes and @number@ and @percent@ for prediabetes , respectively.
Sensitivities of OSTA index at a cutoff value of @number@ and @number@ were @percent@ and @percent@ respectively , and the specificities were @percent@ and @percent@.
Sensitivities , specificities , and likelihood ratios with their @percent@ confidence intervals ( @percent@ CIs ) were calculated.
Sensitivity analyses assessed the robustness of the base-case analysis.
Sensitivity analyses conducted using multiple imputations to account for missing data confirmed these findings.
Sensitivity analyses confirmed that one specific disease did not drive the association and that competing mortality did not bias the association.
Sensitivity analyses demonstrated model robustness.
Sensitivity analyses failed to identify publication bias.
Sensitivity analyses , however , indicated that the interactions appeared to be driven by selection effects.
Sensitivity analyses in a subpopulation of men without antihypertensive medication confirmed these findings.
Sensitivity analyses provided further support for the robustness of these findings.
Sensitivity analyses showed that this result was rather robust for varying parameters deterministically , although cost savings were lost in some instances.
Sensitivity analyses stratified by TBI severity produced similar results.
Sensitivity analyses suggested a less curved dose-response in women.
Sensitivity analyses to test for confounding , reverse causality , and attrition were conducted.
Sensitivity analyses were performed on VE , duration of immunity , and levels of vaccine-induced cross-protection between B lineages.
Sensitivity analyses were specifically targeted at the characteristics of the type-specific HPV test in the screening practice and vaccine efficacy.
Sensitivity analyses where adherence was defined different show no relationship between adherence and use of OTC medicine.
Sensitivity analysis confirmed this relationship.
Sensitivity analysis of cost calculation with different discount rates was performed to improve robustness of our health economic evaluation.
Sensitivity analysis revealed considerable decision uncertainty corresponding to limited evidence about different treatment alternatives for peri-implantitis treatment.
Sensitivity analysis using sparse data methods included remaining trials.
Sensitivity analysis was also conducted by repeating the EFA on demographic subsets of caregivers.
Sensitivity analysis was performed on the base-case results.
Sensitivity and negative predictive value for CRC were @percent@ ( @percent@ CI : 84.9%-98.7% ) and @percent@ ( @percent@ CI : 99.1%-99.9% ) respectively.
Sensitivity and scenario analyses also indicated cost savings or cost-effectiveness below this same threshold.
Sensitivity and specificity of each cut-off score were assessed.
Sensitivity and specificity of RCM for LM diagnosis and κ value to establish correlations between dermoscopy , RCM , and histopathology were performed.
Sensitivity and specificity , positive ( LR + ) and negative ( LR- ) likelihood ratios , and crude and adjusted hazard ratios were computed.
Sensitivity and specificity reached values of @number@ and @number@ at the @date@ cut-off and of @number@ and @number@ at the @date@ cut-off , respectively.
Sensitivity and specificity were calculated for a cut-off point of @number@
Sensitivity clusters could be defined by differential responses to selective pan-PI3K inhibition vs. compounds acting more down-stream.
Sensitivity in recognizing impairment in the validation analysis was @percent@ with @percent@ specificity ( area under the curve = @number@ ) .
Sensitivity of informant-derived lifetime mood disorder diagnoses was compromised by higher Extraversion and higher Agreeableness.
Sensitivity of the proxy assessment instruments varied between @number@ and @number@ %.
Sensitivity ranged from @number@ to @percent@ and specificity from @number@ to @percent@.
Sensitivity ranged from @percent@ to @percent@ , and it did not vary substantially with and without medication or a nocturnal SOREMP.
Sensitivity recovery functions were fitted by non-linear regression to a seven-parameter model.
Sensitivity , specificity , accuracy , and precision were calculated for single-trait and dual-trait markers.
Sensitivity , specificity and accuracy have been @number@ @number@ and 90 & , respectively.
Sensitivity , specificity , positive and negative predictive values were calculated for detection of colorectal cancer.
Sensitivity , specificity , positive predictive value , negative predictive value and likelihood ratios were calculated for index tests.
Sensitivity , specificity , predictive values , and likelihood ratios were reported.
Sensitivity to life course dynamics is crucial to understanding etiological contributions to adult cognitive performance and cognitive aging.
Sensitivity to radial optic flow is still immature at 16years of age , indicating late maturation of higher cortical areas.
Sensitivity to the socially anxiolytic effects of ethanol can be modified by prior stress or ethanol exposure at both ages.
Sensitivity without computed tomography was @percent@ to @percent@ ( median , @percent@ ) .
Sensitization to inhalant allergen was measured using skin prick tests for @number@ common allergens.
Sensitization to TRAIL coincided with and depended on MYC upregulation and massive changes in gene regulation.
Sensitized microglia are a primary source of this exaggerated neuroinflammatory response and appear to be a hallmark of the normal aging brain.
Sensorimotor deficits due to aging might alter postural responses to visual manipulation , especially in more demanding tasks.
Sensorimotor deficits were assessed using an adhesive removal test and the findings were correlated with inflammatory markers.
Sensorimotor functions were independently assessed by the Timed Up and Go ( TUG ) and postural stability tests.
Sensorimotor performance declines with normal aging.
Sensorimotor regions tended to show increasing homotopic RSFC , whereas higher-order processing regions showed decreasing connectivity ( i.e. , increasing segregation ) with age.
Sensorineural systems play a crucial role in the diagnosis , treatment and management of several neurological disorders.
Sensory decline is viewed as an inevitable consequence of the ageing process.
Sensory functioning was generally a stronger predictor of personality change than disease burden or depressive symptoms.
Sensory impairments contributed to decreased postural sway complexity , which reflected reduced adaptive capacity of the postural control system.
Sensory impairments in midlife are associated with subtle deficits in cognitive function which may be indicative of early brain aging.
Sensory NCSs were performed by standard antidromic technique.
Sensory nerve blockade abolished these differences among the groups ( P > @number@ ) .
Sensory nerve function was assessed using 10-g and @number@.4-g monofilaments and sural sensory nerve conduction amplitude and distal latency.
Sensory nerve function was assessed with 10-g and @number@.4-g monofilaments and average vibration detection threshold at the toe.
Sensory nerve function was measured using 10- and @number@.4-g monofilaments and vibration detection threshold at the toe.
Sensory neuropathy is associated with substantial long-term disability and frequently requires management with analgesics.
Sensory-processing abilities that are known to deteriorate with age may reduce occupational engagement.
Sensory receptive fields in trained rats exhibited improved spectral and spatial selectivity.
Sensory suppression associated with elevated vibration levels on a construction site may increase the danger of losing balance.
Sensory testing of the genital area showed various points of static mechanical hyperesthesia at the left dermatome of the pudendal nerve.
SEP across life impacts on midlife physical performance , and thereby the ageing process.
SEP amplitude could be one of the surrogate markers of the degree of cortical hyperexcitability in ULD during the long-term follow-up period.
SEP amplitudes of P25 and N35 were enlarged in all patients and were gradually decreased with aging in ULD on average.
Separate analyses for both age groups revealed age differential explanation patterns.
Separate analyses were made for 12-month survivors and from an intention-to-treat perspective.
Separate analysis focusing on urban elderly and rural elderly revealed broadly similar results.
Separate assessment tools exist for both malnutrition and frailty ; however , there is intersection between concepts and measures.
Separated by age groups only aLM index was correlated with KE : KF 1-RM ratio for the OG ( r = 0·780 ) .
Separate densities of skin tissue , AT , muscle tissue and bone were obtained by hydrostatic weighing.
Separate logistic regressions were used to compare SI and non-SI subjects.
Separately the non-linear effect of θ° on IOPG cannot be ignored for reasons of precision.
Separate measures are also needed to address disparities in socioeconomic circumstance from village to village.
Separate models were used to assess the influence of the number of diseases on the same variables.
Separate multivariate linear regression models were used to examine the association of executive function , depressive symptoms , and symptoms of GAD with A1C.
Separate multivariate regression models were employed to examine the impact of socio-demographic , health , and health behaviors on cognitive functioning among older adults.
Separate multivariate regression models were employed to examine the impact of socio-demographic , health , and health behaviors on cognitive functioning among older adults.
Separate psychosocial factors showed modest mediating effects on the outcomes.
Separate reference values of LV EF and volumes need to be applied in both women and men depending on the software package used.
Separating oligomers from monomeric peptide by size exclusion chromatography produced effects at peptide concentrations approaching physiologic levels ( 10-100 nM ) .
Separating these components may be useful for deciphering the genetic variation in age-related memory abilities.
Separating the two conditions is of vital importance because treatment strategies differ completely.
Separation or self-reported traumatic experiences were not associated with LTL.
SEP , especially income and occupational class , accounted for most of the mortality differentials by country of birth.
SEPs confirmed these results , with older adults having longer latencies and reduced amplitudes.
Sepsis represents the host's systemic inflammatory response to a severe infection.
Sepsis was defined as organ dysfunction caused by a dysregulated host response to infection and identified with International Classification of Diseases 10th revision codes.
Sepsis with fungus was rare but was more prevalent in adult sepsis patients ( @percent@ ) than in neonatal patients ( @percent@ ) .
SEPs were recorded at the Cz electrode with reference to Fz.
Septal systolic motion is towards the left ventricle ( LV ) in healthy hearts.
Septic arthritis and spondylitis in elderly adult are uncommon disease.
Septic encephalopathy is a manifestation especially of severe sepsis and septic shock where the neurologist plays a crucial role in diagnosis and management.
Sequence analysis of ALS cohort identified @number@ novel variants on SOD1 ( p.Glu41Gly ) and FUS ( p.Gly496Glyfs 31 ) .
Sequence analysis of hTERT and hTERC showed overrepresentation of synonymous and intronic mutations among centenarians relative to controls.
Sequence analysis revealed conservation of domain structure and the unique imperfections in the triple helical domain.
Sequence geometry specifically influenced navigation , not reaching.
Sequence interruptions in the repeats have been described in the majority of these disorders and may influence disease phenotype and heritability.
Sequence position of the target IOI differed across conditions.
Sequencing analysis identified @number@ variants within BIN1.
Sequencing analysis identified @number@ variants within PICALM including @number@ new variants with extreme low frequency in the northern Han Chinese population.
Sequencing data suggest that observed effects are not due to rare mtDNA variants but rather the combination of SNPs representing the J versus H haplogroups.
Sequencing identified a premature stop codon and frame-shift in exon @number@ providing a molecular explanation for HA.
Sequencing of LMNA revealed a novel heterozygous de novo mutation p.L306R located in the α-helical rod domain of A-type lamins.
Sequential logistic regressions showed self-reported difficulty and physical performance were significant independent predictors of each category of CS.
Sequestration of Cu2 + by α-crystallin prevents metal-ion mediated oxidation.
SE refraction is the only significant predictor of RNFL thickness.
Serial cognitive testing , conducted over @number@ years , began @number@ years after dietary assessment.
Serial CSF and plasma samples were collected before administration and @number@ h , @number@ h , @number@ h , @number@ week and @number@ weeks post-dosing.
Serial skin samples were obtained at baseline and at various times after treatment.
Series of neuropsychological tests were administered.
Series of studies on senescence-associated secretory phenotype ( SASP ) in particular have revealed various layers of functionality of senescent cells in vivo.
Serious adverse events were mostly relapse related.
Serious adverse events were similar in the two groups.
Serious complications associated with this disorder include cardioembolic stroke , heart failure , and death.
Serious complications from fillers are rare but potentially devastating to patients and physicians.
Serious consideration should be given to delirium risk identification and modification programs.
Serious event are mostly caused by NSAIDs and / or aspirin which are the most widely prescribed medications in the world.
Serious games are emerging as virtual educational and pleasurable tools , designed for individual and cooperative skill building.
Serious nephrotoxicity was observed in @number@ cases ( @percent@ ) after administration of PIPC TAZ.
Ser ( @number@ ) mutations did not affect fibril formation , indicating an unprimed mechanism of Thr ( @number@ ) phosphorylation.
Serological examination for NMO-IgG was not performed in all the cases.
Serological testing for KIR4.1-specific IgG is unlikely to aid diagnosis of multiple sclerosis.
Serologic and immunologic deficits were most frequent in older HIV-infected participants.
Serologic studies can provide important insights into the epidemiology and transmission of Pneumocystis jirovecii.
Seronegative control subjects were age- and sex-matched with the ART naive patients and the two other groups.
Seronegative pregnant woman often acquire primary HCMV from clinically asymptomatic , but HCMV-shedding children.
Seroprotection was defined as an influenza antibody concentration≥160 units.
Seroresponses to influenza vaccination were measured by tests to the A / H3N2 strain at all time points.
Serostatus groups had similar amount of WMH volume growth over time.
Serostatus was not a predictor of disease stage in the studied population.
Serotonin ( 5-hydroxytryptamine ; 5HT ) is a neurohormone , which plays a role in sleep / wake regulation and affective disorders.
Serotoninergic mechanisms seem to play an important role in haemostasis , and their importance in this regard has long been underestimated.
Serotonin , or 5-hydroxytryptamine ( 5-HT ) , is found to be involved in many physiological or pathophysiological processes including cognitive function.
Serotype identification was performed using direct sequencing technique.
Serovar determination of the C. trachomatis-positive specimens was carried out by an omp1 PCR-based RFLP analysis method.
Serrated pathway polyps are a relatively new area of interest in the field of colorectal cancer screening and prevention.
SERT density was up-regulated in the amygdala in PRX-treated adolescents only while DAT density in the nucleus accumbens was down-regulated only in PRX-treated adults.
Sertoli cell ( SC ) number per tubule in two-dimensional was significantly less in aged men than that of young men , p < 0.01.
Serum 17OHP significantly increased throughout prepuberty ( p < @number@ ) .
Serum 25-hydroxyvitamin D [ 25 ( OH ) D ] levels were determined using chemiluminescent immunoassay.
Serum 25-hydroxyvitamin D ( 25OHD ) levels were measured at the baseline.
Serum 25-hydroxyvitamin D [ 25- ( OH ) D ] was assessed by radioimmunoassay at baseline and @number@ years later.
Serum 25-hydroxyvitamin D concentrations were assessed at year @number@
Serum 25OHD3 and @number@ , 25 ( OH ) 2D3 were also correlated with urinary steroid metabolites , suggesting a link with glucocorticoid metabolism.
Serum 25 ( OH ) D and intact parathormone ( PTH ) concentrations were measured by radioimmunoassay and by a 2-step immunoradiometric assay , respectively.
Serum 25OHD and intramuscular VDR protein expression were examined by immunoblot.
Serum 25 ( OH ) D concentration , indicating vitamin D status , was measured at age @number@ years.
Serum 25 ( OH ) D concentrations were obtained from @number@ centenarians and near centenarians ( @number@ years and older ) .
Serum 25 ( OH ) D concentrations were significantly correlated with age ( r = 0.21 , P = 0.024 ) .
Serum 25 ( OH ) D concentrations were used to assess vitamin D status.
Serum 25 ( OH ) D concentrations were used to define vitamin D status , and were categorized into tertiles.
Serum 25 ( OH ) D increased in supplemented group compared to placebo @number@ ng / ml versus @number@ ng / ml respectively.
Serum 25 ( OH ) D levels were measured at admission.
Serum 25 ( OH ) D levels were measured at the time of enrollment in 1998-1999 , and participants were followed up for mortality.
Serum 25 ( OH ) D level was measured by chemiluminescent microparticle immunoassay.
Serum 25OHD was measured , and intramuscular VDR , IL-6 , and TNFα gene expressions and protein concentrations were analyzed.
Serum 25-OH vitamin D , calcium , and intact parathyroid hormone were also measured.
Serum albumin and PCR were also assessed.
Serum alkaline phosphatase levels were significantly higher in the dogs with moderate to severe valvular regurgitation compared to the rest of the cohort.
Serum AMH and AFC started to decline in women between @number@ and @number@ years old.
Serum AMH assay is more sensitive , more specific and more reproducible that counting of ovarian follicles by ultrasound.
Serum AMH concentrations followed a steady reduction with increasing age.
Serum AMH concentrations show a progressive decline with female ageing.
Serum AMH , INH , ovarian volume , and AFC were lower while serum FSH was higher in cancer survivors.
Serum AMH levels become low approximately @number@ years before the final menstrual period and are undetectable in postmenopausal women.
Serum antibodies to intestinal microbial antigens in IBD are thought to reflect a loss of tolerance in the setting of genetically encoded innate immune defects.
Serum anti-Müllerian hormone ( AMH ) levels are regarded as an age-specific marker for predicting the ovarian reserve in women of reproductive age.
Serum- as well as CSF-tau levels were significantly elevated in CJD group compared to those in AD , non-CJD-RPD and healthy control groups.
Serum-based clinical biomarkers of vascular risk and biomarkers of inflammation related to AD were analyzed.
Serum BDNF concentration and atrophy of the right medial temporal lobe may in part mediate the relationships between depressive symptoms and cognitive decline.
Serum bicarbonate was measured using arterialized venous blood gas.
Serum biomarkers measured on admission : troponin I , C-reactive protein ( Abbott ) , and Lp-PLA ( @number@ ) ( DiaDexus ) .
Serum biomarkers of oxidative stress , the reactive oxygen metabolites , of the antioxidant status , the biological antioxidant potential did not change.
Serum blood urea nitrogen and creatinine were measured for renal function.
Serum C1q level may reflect loss of muscle mass ; therefore , C1q may be a novel biomarker of sarcopenia.
Serum CA @number@ levels did not enable identification of older patients who would benefit from surgery.
Serum carotenoid concentrations were measured at baseline and at @number@ @number@ @number@ @number@ and @number@ mo follow-up visits.
Serum carotenoids were measured using high performance liquid chromatography.
Serum CD4 ( + ) T-lymphocyte counts and SIV copy numbers did not differ between groups.
Serum cholesterol , both total and lipoprotein fractions , has been associated with mid- and late-life depression.
Serum cholesterol measures included total cholesterol ( TC ) , high-density lipoprotein cholesterol ( HDL-C ) , triglycerides , and cholesterol : HDL cholesterol ratio.
Serum concentrations of adiponectin and sialic acid were significantly higher in sarcopenic than non-sarcopenic CVD patients.
Serum concentrations of α-tocopherol and γ-tocopherol were highest among the hip fracture population after adjustment ( P < @number@ ) .
Serum concentrations total , bioavailable and free testosterone , as well as of follicle-stimulating hormone and luteinizing hormone were quantified in every patient.
Serum cortisol , insulin , estradiol , growth hormone had no significant age and sex differences in the present groups.
Serum creatine kinase is usually below @number@ IU / L. sIBM is generally refractory to current therapy , such as steroids or immunosuppressants.
Serum creatinine decreased among dolphins older than @number@ years compared to when they were 30-40 years old.
Serum creatinine measurements were taken a mean @number@ years apart.
Serum CRP levels were measured using a high-sensitivity assay at baseline and the 13-year follow up.
Serum CRP levels were within the normal range for all subgroups.
Serum cystatin C and kidney volume are significantly lower in school-age ELBW children.
Serum cystatin C concentration and the CG and MDRD formula might be valuable parameters , although there is insufficient evidence.
Serum cytokine levels were assayed by ELISA , and CRP using an immunoturbidimetric method.
Serum cytokine levels were low.
Serum deprivation induced SIRT2 expression , while SRF and the SRF binding protein , p49 / STRAP , repressed SIRT2 gene expression.
Serum deprivation of ARPE-19 was associated with increased formation of FM dye-positive membrane vesicles , many of which co-labeled for UC.
Serum DHEAS was inversely proportional to age in both genders.
Serum dihydrotestosterone increased in the testosterone only but decreased in the testosterone plus dutasteride group.
Serum Dkk1 expression as quantified by ELISA was correlated with lumbar and femoral t- and z-scores.
Serum E2 level was negatively correlated with the parasympathetic parameter of rMSSD , and positively correlated with LF / HF24 hours and GSI.
Serum E2 seemed to be a positive determinant factor of skeletal regions and @number@.5%-5.4% changes in BDR were determined by E2.
Serum EPA was not associated with cognitive decline.
Serum ferritin concentrations also decline , although there is no evidence to suggest that changes in iron stores are an inevitable consequence of ageing.
Serum fetuin-A levels were measured using ELISA and the modified NCEP-ATP III criteria were adopted to diagnose MetS.
Serum FGF21 levels were measured with an ELISA kit.
Serum FGF-23 concentrations and blood pressure ( BP ) were measured in the all subjects.
Serum folate , vitamin B-12 , and tHcy were mainly expressed as tertiles.
Serum free testosterone levels ( FT ) and these four scores were compared before and after TRT.
Serum from patients with SAM was obtained at hospital admission and @number@ d after nutritional stabilization and from community controls.
Serum FSH levels differed significantly in subjects with non-malignant , pre-malignant , and malignant prostate conditions.
Serum FSH levels in these women were significantly increased , whereas antral follicle counts and serum anti-Müllerian hormone levels were decreased.
Serum galactose-deficient immunoglobulin A1 ( Gd-IgA1 ) is an inherited risk factor for adult IgA nephropathy ( IgAN ) .
Serum Gd-IgA1 concentrations were quantified using a Helix aspersa-lectin-based enzyme-linked immunosorbent assay.
Serum HA level correlated with VAS of knee pain and / or KOOS Pain in the Normal and Moderate groups.
Serum HBV and hepatitis C virus ( HCV ) markers were regularly measured.
Serum hormones and metabolic measures were compared between women meeting each element of the Rotterdam criterion and those without PCO using age-adjusted linear regressions.
Serum hs-CRP levels were measured using a highly sensitive latex aggregation immunoassay.
Serum IGF-1 below but not above the median was inversely related to fracture incidence.
Serum IGF-1 concentrations were declined with age in both males and females after the age of @number@
Serum IGF-1 concentrations were determined by immunoradiometric assay ( IRMA ) .
Serum IGF-1 concentration was determined at baseline.
Serum IGF1 is a reliable measure of integrated GH concentrations in patients with acromegaly.
Serum IGF-1 levels were assessed at baseline via fasted blood draw.
Serum IGF-1 was measured at baseline by radioimmunoassay.
Serum IGF-I was determined by electrochemiluminescent immunoassay.
Serum IL6 , TNFα and IL10 were higher among patients with depressive symptoms at @number@ weeks.
Serum IL-8 was determined with a bead array.
Serum influenza antibody , nasal immunoglobulin A , and peripheral blood mononuclear cell interferon-γ ( IFNγ ) and interleukin-10 ( IL-10 ) concentrations were measured.
Serum insulin levels acutely dropped following treatment , but peripheral glucose levels remained unchanged.
Serum intact parathyroid hormone ( β = @number@ P = @number@ ) was negatively associated with △LF.
Serum interleukin-6 decreased ( @number@ vs @number@ pg / ml ) and MMP-3 ( @number@ vs @number@ ng / ml ) increased.
Serum Klotho levels were determined by the ELISA method.
Serum leptin levels were measured using direct sandwich ELISA.
Serum level of IL-6 correlated positively with activation markers of NK cells.
Serum levels of 25-hydroxyvitamin D were lower , while PTH higher in patients with post-partum thyroiditis than in patients without thyroid autoimmunity.
Serum levels of 25-hydroxyvitamin D were significantly increased in group C , but not changed in groups A and B at 24-month follow-up.
Serum levels of AMH and FSH had the highest diagnostic accuracy ( ROC AUC , @number@ and @number@ respectively ) for LMT.
Serum levels of AMH , FSH , LH , progesterone and estradiol were measured.
Serum levels of CPPs are increased in CKD patients and independently associated with vascular calcification and chronic inflammation.
Serum levels of creatinine , bone alkaline phosphatase and urinary deoxypyridinoline levels were determined in one laboratory.
Serum levels of cytokines were analyzed by ELISA.
Serum levels of IgE antibodies to CM were measured using UniCAP.
Serum levels of IL-6 , CRP , and TNF-R1 were greater in participants ≥65 than < 65 years of age.
Serum levels of MCP-1 were measured by enzyme-linked immunosorbent assay ( ELISA ) .
Serum levels of NT-proBNP , estradiol , testosterone and sex hormone-binding globulin ( SHBG ) were measured.
Serum levels of @number@ inflammatory proteins , including cytokines , growth factors , and acute phase proteins , were measured at baseline.
Serum levels of pro-inflammatory cytokines elevated beyond normal ranges indicate particular diseases.
Serum levels of reproductive hormones were obtained for all subjects ; APOE-ε4 haplotype was determined for @number@ women.
Serum levels of sRAGE and advanced glycation end products ( AGEs ) were determined using enzyme-linked immunosorbent assay.
Serum levels of total cholesterol were higher in the APOE E4 group ( P < 0.05 ) .
Serum levels of t-PA and VWF were measured at baseline.
Serum levels of TT were collected on the same day that men completed their ADAM questionnaires.
Serum levels of vitamin D show correlation with the risk of infections , cardiovascular diseases , cancer and autoimmune disorders.
Serum levels of δ-tocopherol were also lower in participants with greater levels of smoking ( p = @number@ ) .
Serum lipid parameters were correlated with several environmental factors , including age , gender , DBP , SBP , and BMI.
Serum lipids and risk factors were measured.
Serum liver injury markers of alanine transaminase , aspartate transaminase , and hepatitis viral infection were measured.
Serum L , measured at the baseline examination , was significantly associated with MPOD measured at follow-up.
Serum malondialdehyde ( MDA ) , superoxide dismutase ( SOD ) , and glutathione peroxidase ( GPx ) levels were analyzed in both groups.
Serum MIC-1 / GDF15 is a novel predictor of all-cause mortality.
Serum MIC-1 / GDF15 levels were determined for all subjects from samples taken at study entry.
Serum MIC-1 / GDF15 remained an independent predictor of mortality when further adjusted for telomere length , IL-6 and CRP.
Serum microRNAs have potential to serve as noninvasive markers for diagnostics / prognostics and therapeutic targets.
Serum miR-21 and miR-146a levels and FasL concentrations were lower in HRT users compared to their non-using co-twins , demonstrating their responsiveness to HRT.
Serum MLT levels were measured in both the light and dark phases.
Serum MLT levels were measured using the enzyme-linked immunosorbent assay.
Serum neopterin and IL-6 levels were measured using standard enzyme-linked immunosorbent assay.
Serum NGAL could be a sensitive marker of kidney function , particularly in elderly patients.
Serum NGAL , cystatin C , creatinine , and eGFR were evaluated in all patients.
Serum NT-pro-BNP and adipokines levels ( adiponectin and leptin ) were measured.
Serum NTproBNP concentrations showed significant positive correlations with SHBG in peri- and postmenopausal women.
Serum NT-proBNP concentration was significantly decreased after GnRH agonist administration , while NT-proBNP concentration in the control group did not change significantly.
Serum potassium is associated with ventricular arrhythmias and cardiac arrest.
Serum procalcitonin was measured on days @number@ @number@ and @number@ and at the end of treatment.
Serum proteomics analysis may lead to the discovery of novel osteoporosis biomarkers.
Serum quantification of HBsAg and HBVDNA was obtained regularly during the follow-up.
Serum retinol didn't show this behavior.
Serum samples from the two groups were analyzed by gas mass spectrometry and Acquity ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
Serum samples of @number@ patients were analyzed with the anti-CCP ELISA assay method established in our laboratory.
Serum samples were analyzed for anti-HSV antibodies ( immunoglobulin ( Ig ) G and IgM ) by enzyme-linked immunosorbent assays.
Serum samples were analyzed from @number@ PD cases and compared to a random sample of @number@ AD cases and @number@ controls.
Serum samples were fractionated on magnetic beads MB WCX using ClinProt robot prior to mass-spectrometry based profiling.
Serum sclerostin levels are associated with cortical porosity , suggesting that changes in sclerostin production during growth may play a role in defining cortical structure.
Serum serotonin , sclerostin , dickkopf-related protein @number@ ( DKK1 ) , and BTM were evaluated.
Serum SHBG level was also significantly decreased after GnRH agonist administration.
Serum sIL-6r was higher in Japanese than Americans , but was most notably low in African-Americans.
Serum sodium was measured and urine samples were assessed for color and electrolyte content.
Serum specimens were collected from the peripheral and ovarian veins of participants undergoing bilateral oophorectomy.
Serum starvation prevented induction of senescence , but not of p53 , by etoposide.
Serum TAGE predicts poor ART outcomes independent of age and Day-3 FSH.
Serum-tau would be a simple and useful marker to distinguish CJD from AD and non-CJD-RPD , requiring further large study to confirm this.
Serum T , DHT , E2 , and E1 levels were not associated with incident fractures in univariate or multivariate-adjusted analyses.
Serum testosterone increased similarly into the mid-normal range in both groups.
Serum testosterone levels and gonad function decline with the aging of males.
Serum TNF-α levels decreased in the 100M-group ( p = @number@ ) .
Serum T ≤ @number@ ng / dl is considered to be low , and T ≤ @number@ is considered to be frank hypogonadism.
Serum total and allergen-specific IgE ( sIgE ) levels were measured by using ImmunoCAP.
Serum Total Antioxidant Status ( TAS ) and Total Peroxide ( TPx ) levels were determined with new automated methods.
Serum total calcium , phosphorus , creatinine , intact PTH , and 25 ( OH ) D were measured.
Serum total cholesterol , high-density lipoprotein , triglycerides , and homocysteine levels were measured in fasting blood samples.
Serum total estradiol and total testosterone were measured by mass spectrometry , and bioavailable sex steroids were calculated from mass action equations.
Serum total testosterone ( TT ) and free testosterone ( FT ) levels were measured using enzyme-linked immunosorbent assay ( ELISA ) .
Serum total testosterone ( TT ) , free testosterone ( FT ) , dihydrotestosterone ( DHT ) and estradiol ( E2 ) levels were measured.
Serum triglyceride ( TG ) levels decreased to @number@ and @percent@ from initial levels in the YN and MN groups , respectively.
Serum TSH was measured at baseline.
Serum TSH was sub-normal in @percent@.
Serum TT concentrations , measured by chemiluminescent enzyme immunoassays , were categorised into age-specific quartiles.
Serum UA was measured in baseline serum samples.
Serum uric acid is a powerful antioxidant that may have neuroprotective properties.
Serum uric acid was an independent risk factor of incident fatty liver detected by ultrasonography.
Serum values are almost undetectable during infancy and then rapidly increase with the onset of puberty , reflecting the initial recruitment of primordial follicles.
Serum vitamin D concentration is associated with falls , and vitamin D administration decreases falls.
Serum vitamin D levels were determined by radioimmunoassay , and body composition was evaluated by dual-energy x-ray absorptiometry.
Serum vitamin D levels were negatively correlated with age and positively correlated with lumbar spine areal and volumetric BMD.
Serum vitamin D level was measured with ELISA ( nmol / L ) and receptor gene polymorphism was determined by PCR.
Serum was available from @number@ out of the @number@ participants at baseline and after 12weeks for determination of eHsp70.
Serum was collected for BDNF assay at baseline and after @number@ weeks ( @number@ h-48 h after the last training ) .
Serum was collected from a cohort of patients ( n = @number@ ) , @number@ patients with a reduced BMD and @number@ control patients.
Service delivery to meet all preferences presents a challenge for health service design.
Service dogs help people with mobility impairments.
Service-learning is an innovative teaching-learning-service method that provided reflective and hands-on experience of gerontological nursing.
Service providers may also need to adopt the use of new technologies to communicate with increasingly time-pressured family members.
Services currently offering weekly CST should collect routine outcome data to support its use and provide practice-based evidence.
Services for the elderly , whether in the community or in hospitals , and including end-of-life care , were ranked among the lowest.
Services making use of information and communication technology ( ICT ) are of potential interest to face the challenges of our aging society.
Services that are lesbian- and gay-friendly may facilitate service uptake and reduce pressures on lesbian and gay people's informal networks of support.
Services will be provided to community-dwelling participants with support from Aging and Disability Network Agencies.
Seryl-tRNA synthetase ( SerRS ) , an essential enzyme for translation , also regulates vascular development.
SES differences largely explained this ethnic disparity.
Sesns promote activation of ( AMP ) -dependent protein kinase in both mammals and flies.
Session frequency was five times a week , where sessions consisted of supervised PA combined with educational sessions.
Session presentations will be considered in the context of the broader topic of indices and predictors of aging-related change.
SES was assessed using a subjective social status rating representing where people stand in society.
SES was a stronger predictor for Blacks / African Americans , whereas cognitive function was a stronger predictor for Whites.
SES was defined by means of early-life education , longest occupation , and late-life financial conditions.
SES was defined from information on formal education , longest held occupation , and financial conditions through life.
SES was evaluated by educational attainment and household income.
SES was indexed using household income.
SES was inversely associated with a composite measure of AL ; hostility and poor sleep quality helped to explain the association between AL and SES.
SES was measured by census tract poverty level ( average of @number@ and @number@ Census data ) .
Set in the context of inner-city Toronto , Canada , this article reports on the findings from qualitative interviews with @number@ formerly homeless older persons.
SETTING : 1988-1994 and 1999-2002 rounds of the National Health and Nutrition Examination Survey ( NHANES ) .
SETTING : 2001-2011 data of the National Health Insurance database.
SETTING : 2010-2011 rounds of the Korean National Health and Nutrition Examination Survey.
SETTING : 204-bed inpatient NH in Bern , Switzerland.
SETTING : A 22-bed mixed surgical and medical ICU.
SETTING : a 450-bed hospital in the Netherlands.
SETTING : A 900-bed teaching hospital in Israel.
SETTING : A biomechanics laboratory of a tertiary university hospital.
SETTING : Academic biomedical imaging laboratory.
SETTING : Academic institution.
SETTING : Academic medical center.
SETTING : Academic medical center.
SETTING : Academic medical center.
SETTING : Academic medical center.
SETTING : Academic medical center.
SETTING : Academic medical centers.
SETTING : Academic medical center , Winston-Salem , North Carolina.
SETTING : Academic referral hospital sleep laboratory.
SETTING : Academic research center.
Setting : Academic research institution.
SETTING : Academic skin cancer prevention clinic with high-level experience in assessment of sun-damaged skin.
SETTING : Academic tertiary care hospital.
SETTING : A cohort of community-recruited elderly individuals at the Alzheimer Disease Center of the University of California , Davis.
SETTING : A community-based aging services agency.
SETTING : A community-based geriatric dental clinic in Minnesota.
SETTING : A community-based primary care practice in Kitchener , Ont.
SETTING : A community-based prospective cohort , the Kungsholmen-Nordanstig Project.
SETTING : A community-based study.
SETTING : A community-based study.
SETTING : A community recently converted to urban status with a newly constructed CHC in Southwest China.
SETTING : A cross-sectional , nationally representative sample of adults , with prevalence estimates weighted to represent the civilian , noninstitutionalized US population.
SETTING : Acute care for elders units of university hospital of Grenoble.
SETTING : Acute care geriatric and medical wards of five Italian hospitals.
SETTING : Acute care , Medicare participating hospitals from @number@ to @number@
Setting : acute hospital ( excluding critical care and subacute or intermediate care ) .
SETTING : Acute inpatient rehabilitation and follow-up in the community.
SETTING : Acute inpatient rehabilitation facilities.
SETTING : Adelaide , South Australia.
SETTING : Adult patients hospitalized in the United States between @number@ and @number@ identified in the Nationwide Inpatient Sample.
SETTING : Adults recently discharged from an aged care and rehabilitation service in Australia who were enrolled in a clinical trial.
SETTING : A general internal medicine unit of a university hospital in Italy.
SETTING : A general-population cohort in France.
SETTING : A laboratory of neuromuscular research and active aging.
SETTING : Albacete city , Spain.
SETTING : All short-stay inpatient hospitals in the United States , @number@ to @number@
SETTING : all subjects were born in Calabria ( southern Italy ) and their ancestry in the region was ascertained up to the grandparents.
SETTING : All territorial provinces in Poland.
SETTING : A longitudinal study started at @number@ in Hong Kong.
SETTING : Alzheimer Center , SS.
SETTING : Alzheimer's Association support groups for family members of individuals with dementia.
SETTING : A major medical institution.
SETTING : A major medical institution.
SETTING : Ambulatory patients with HF were recruited at Charité Medical School , Campus Virchow-Klinikum , Berlin , Germany.
SETTING : Ambulatory population.
SETTING : A nationally representative , population-based sample of community-dwelling adults.
SETTING : A nationally representative sample from the Second Longitudinal Study of Aging ( LSOA II ) .
SETTING : A national survey.
SETTING AND METHODS : Dual energy X-ray Absorptiometry ( DXA ) at the Osteoporosis Clinic in North Denmark was reorganised from @number@
SETTING AND PARTICIPANTS : adults aged @number@ and over living in the community ( n = @number@ ) .
SETTING AND PARTICIPANTS : a total of @number@ men and women aged 63-73 years who were taking part in the Hertfordshire Cohort Study.
SETTING AND PARTICIPANTS : A total of @number@ subjects with a mean ± standard deviation age of @number@ ± @number@ years were included.
SETTING AND PARTICIPANTS : coordinating physicians in @number@ nursing homes in France.
SETTING AND PARTICIPANTS : Cross-sectional study within a large cohort of community-dwelling older men , the MrOS study.
SETTING AND PARTICIPANTS : Data of @number@ patients were analyzed between @date@ and @date@ .
SETTING AND PARTICIPANTS : Functionally disabled home-dwelling elderly receiving home care.
SETTING AND PARTICIPANTS : Geriatric outpatients center.
SETTING AND PARTICIPANTS : @number@ men and women > @number@ years of age who were living in Cache County , Utah in @number@
SETTING AND PARTICIPANTS : @number@ non-demented and ambulatory community-dwelling older adults ( mean age @number@ years , @percent@ women ) .
SETTING AND PARTICIPANTS : Patients ≥ @number@ years admitted to a 1024-bed tertiary teaching hospital in the Netherlands.
SETTING AND PARTICIPANTS : The questionnaires were sent to the nursing staff and administrators in a hospital through e-mail and posts.
SETTING AND PARTICIPANTS : The United States population aged 15-64 years.
SETTING AND PARTICIPANTS : Top executives in a national sample of LHDs.
SETTING AND PARTICIPANTS : We studied a population-based sample of @number@ Dutch women with natural menopause.
SETTING AND POPULATION : @number@ women and their children sampled from the Danish National Birth Cohort.
SETTING : An emergency department located within an academic , tertiary care hospital.
SETTING : A neurorehabilitation center and a dental school.
SETTING : Angers University Hospital , France.
SETTING : An inpatient pulmonary rehabilitation center in Italy.
SETTING : An IVF laboratory in a university hospital in Taiwan.
SETTING : An outpatient clinic was chosen for the study.
SETTING : An urban , public hospital and healthcare system.
SETTING : A population-based study of community-dwelling very elderly adults in a city in southern Brazil.
SETTING : A population-based study of very old people in northern Sweden and western Finland , living in institutional care or in the community.
SETTING : A randomized trial of telemedicine vs. usual care in elderly persons with type @number@ diabetes.
SETTING : A regional SCI outpatient center in Sweden.
SETTING : A representative sample from the Elderly Nutrition and Health Survey in Taiwan during 1999-2000.
SETTING : A retirement home and a social day care centre for old people in Porto , Portugal.
SETTING : A rural community near Qufu in Shandong , China.
SETTING : A single-center tertiary-care hospital.
SETTING : A single Veterans Affairs Medical Center ( VAMC ) , 2002-2012.
SETTING : Assessments were conducted at university and medical research centers.
SETTING : Assisted-living facility.
SETTING : A subset of the Melbourne Collaborative Cohort Study ( MCCS ) .
SETTING : A sub-urban area in Northern Italy.
SETTING : A telephone survey conducted in 2009-2010 collected information on parental perceptions of their neighbourhoods , and household , parent and child demographic characteristics.
SETTING : A tertiary level neonatal intensive care unit in a university-affiliated teaching hospital in Taiwan.
Setting : A tertiary public hospital.
SETTING : A total of @number@ community-based clinics affiliated with a naturopathic medical school.
SETTING : A total of @number@ nursing homes across Italy.
SETTING : a traditional African rural population in Ghana.
SETTING : A transitional care unit ( TCU ) within a Department of Veterans Affairs hospital nursing home care unit.
SETTING : A university hospital.
SETTING : A university hospital in South Korea.
SETTING : Austrian Stroke Prevention Study , a population-based cohort study on brain aging.
SETTING A whole-genome case-control ROH study.
SETTING : Balance and gait laboratory.
SETTING : Baltimore City , Maryland , USA.
SETTING : Baltimore Longitudinal Study of Aging.
SETTING : Baltimore Longitudinal Study of Aging.
SETTING : Baltimore Longitudinal Study of Aging.
SETTING : Baltimore , Maryland.
SETTING : Baltimore , Maryland.
SETTING : Baltimore , Maryland.
SETTING : Baltimore , Maryland.
SETTING : Bambuí , Brazil.
SETTING : Baseline data collection occurred between @number@ and @number@ in or near Columbia , SC.
SETTING : Baseline data from two subsamples of older farmers in southwestern France.
SETTING : Bay of Plenty , New Zealand.
SETTING : Beijing , China.
SETTING : Betula Prospective Cohort Study , a population-based study in Umeå , Sweden.
SETTING : Biracial urban US population sample.
SETTING : Boston , Massachusetts ( general community ) and Harvard University.
SETTING : Both clinics and the community.
SETTING : British Regional Heart Study.
SETTING : British Regional Heart Study.
SETTING : Bronx , New York.
SETTING : Canada.
SETTING : Car-dependent urban and rural neighborhoods in Worcester County , Massachusetts , USA.
SETTING : Cardiac operating room at a single institution.
SETTING : Cardiovascular Health Study.
SETTING : Cases were drawn from the Danish Psychiatric Central Register.
SETTING : Central Alabama.
SETTING : Centre of assisted reproduction Sanus , Pardubice ; PPCHC s.r.o.
SETTING : Chicago metropolitan area.
SETTING : Chronic disease ward of Kyushu University Hospital at Beppu in Japan.
SETTING : Cities of Montréal , Laval , and Sherbrooke in Quebec , CA.
SETTING : City of Lausanne , Switzerland.
SETTING : City of Padua , Italy.
SETTING : Civilian noninstitutional population of the United States.
SETTING : Civil service departments in London ( the Whitehall II study ) .
SETTING : Civil service departments in London , United Kingdom.
SETTING : Clinic.
SETTING : Clinical neuroimaging research center.
SETTING : Clinical research center.
SETTING : Clinical research center.
Setting : Clinical research facility.
SETTING : Clinical research setting with facility based exercise and nutrition education.
SETTING : Clinical setting.
SETTING : Clinical settings.
SETTING : Clinic examinations in Pittsburgh , Pennsylvania , or Memphis , Tennessee.
SETTING : Clinic visit in 1991-93.
SETTING : Communities.
SETTING : communities in I-Lan County of Taiwan.
SETTING : Communities in the South East Region of Singapore.
SETTING : Communities throughout northeastern Illinois.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community.
SETTING : Community and long-term care facilities.
SETTING : Community based.
SETTING : Community-based.
SETTING : Community-based.
SETTING : Community-based aging cohort study.
SETTING : Community-based aging study data.
SETTING : Community-based and primary care setting.
SETTING : Community-based cohort.
SETTING : Community based cohort in three U.S. sites.
SETTING : Community-based cohorts.
SETTING : Community-based , multidisciplinary sports medicine clinic.
SETTING : Community-based prospective cohort study.
SETTING : Community-based research centers.
SETTING : Community-based sample.
SETTING : Community-based samples drawn from three Australian states.
SETTING : Community-based senior centers.
SETTING : Community-based setting in four rural areas in China.
SETTING : Community-based setting in longevity areas in China.
SETTING : community-based study.
SETTING : Community-based study.
SETTING : Community dwellers aged 65 + years living in Sweden between @date@ and @date@ .
SETTING : Community dwelling.
Setting : Community-dwelling adults aged @number@ years or older , Rotterdam , The Netherlands.
SETTING : Community dwelling adults in the Republic of Ireland ( ROI ) .
SETTING : Community-dwelling elderly in Nara , Japan.
SETTING : community dwelling elderly subjects.
SETTING : Community-dwelling elders.
SETTING : Community-dwelling members of a U.S. health maintenance organization.
SETTING : Community dwelling members of Helsinki rheumatoid association.
SETTING : Community dwelling older ( ≥65 ) women.
SETTING : Community-dwelling older adults.
SETTING : Community-dwelling older adults.
SETTING : Community-dwelling older adults.
SETTING : Community-dwelling older adults.
SETTING : Community-dwelling older adults from five Alabama counties in the University of Alabama at Birmingham ( UAB ) Study of Aging.
SETTING : Community-dwelling older adults in the Canadian province of Manitoba sampled in @number@ and followed in @number@
SETTING : Community-dwelling older adults who came to autopsy.
SETTING : Community-dwelling patients and nursing homes residents aged @number@ years and older with a history of chronic constipation.
SETTING : Community-dwelling population in Copenhagen , Denmark.
SETTING : Community-dwelling subjects.
SETTING : Community dwelling vegetarians.
SETTING : community exercise facilities.
SETTING : Community in northern Manhattan.
SETTING : Community ( n = 4 ) and Veterans Affairs ( VA ) NHs ( n = 4 ) .
SETTING : Community nonclinical.
SETTING : Community of Nakanojo.
SETTING : Community of Nakanojo.
SETTING : Community patients receiving primary care at general practitioner ( GP ) practices across England.
SETTING : Community sample.
SETTING : Community sample.
SETTING : Community sample.
SETTING : Community senior centers in B city , South Korea.
SETTING : Community , usual care.
SETTING : comparison between NH residents and H patients.
SETTING : comprehensive geriatric assessment outpatient clinic.
SETTING : Concord Health and Ageing in Men Project , Sydney , Australia.
SETTING : Contiguous United States.
SETTING : Cornea and Laser Eye Institute , Hersh Vision Group , Teaneck , NJ.
SETTING : Crisis intervention training program for police officers in San Francisco.
SETTING : Database of a military health care system.
SETTING : Data collected in the Finnish population-based Health @number@ Survey.
SETTING : Data collection was carried out in the participants ' own homes.
SETTING : Data from @number@ physicians offering screening colonoscopy and participating in a quality assurance program in Bavaria , Germany , were used.
SETTING : Data from the Health , Aging , and Body Composition Study ( years @number@ @number@ and @number@ ) .
SETTING : Data used in this study were collected as part of longitudinal research at the University of California , Davis Alzheimer's Disease Center.
SETTING : Data were collected in two community health centres and one elderly retirement village in Los Angeles , California.
SETTING : Data were drawn from the first and third waves of the Mexican Health and Aging Study.
SETTING : Data were obtained from the @number@ Health and Retirement Study.
SETTING : Day care centres.
SETTING : Dementia caregivers were recruited from eight catchment areas throughout the United States.
SETTING : Department of Anaesthesiology , Queen Fabiola Children's University Hospital , Brussels , Belgium.
SETTING : Department of Clinical Physiopathology , University of Florence , and National Institute of Applied Optics , CNR , Florence , Italy.
SETTING : Department of Food and Nutritional Sciences and the Clinical Health Sciences at the University of Reading.
SETTING : Department of Geriatrics , University Hospital of Montpellier.
SETTING : Department of Mechanical and Aerospace Engineering , Princeton University , Princeton , New Jersey , USA.
SETTING : Department of Ophthalmology , University Hospital of Crete , Crete , Greece.
SETTING : Department of Veterans Affairs national healthcare system.
SETTING : Diagnostic and clinical laboratories.
SETTING : Edmonton , Alta.
SETTING : EEG was recorded with ambulatory recorders in the subjects ' homes.
SETTING : Eight contiguous , predominantly Yoruba-speaking states in Nigeria.
SETTING : Eighteen primary care clinics from eight healthcare organizations.
SETTING : Eight field centers throughout the United States.
SETTING : Eight hospitals in Baltimore , Maryland.
SETTING : Eight Italian municipalities included in the Italian Longitudinal Study on Aging.
SETTING : Eight nursing homes in Southeast Queensland , Australia.
SETTING : Eight post-acute care ( PAC ) facilities.
SETTING : Eight US academic centers.
SETTING : Eight U.S. centers.
SETTING : Einstein Aging Study , a community-based longitudinal aging study.
SETTING : Elderly centres and community centres in Hong Kong.
SETTING : Elderly individuals were recruited via GP offices at six study centers in Germany.
SETTING : Elderly persons own homes.
SETTING : Eleven European countries.
SETTING : Eleven inpatient medical rehabilitation facilities located across the United States.
SETTING : Eleven long-term care sites in Massachusetts and Maine.
Setting : English Longitudinal Study of Ageing.
SETTING : English Longitudinal Study of Ageing.
SETTING : Established population-based cohort in Reykjavik , Iceland.
SETTING : ESTHER cohort ( Germany ) .
SETTING : Facial plastic surgery private practice in Toronto , Ontario , Canada.
SETTING : Fall clinics in two university teaching hospitals in the Netherlands.
SETTING : Falls and Fractures Clinic , Nepean Hospital ( Penrith , Australia ) .
SETTING : Falls and Fractures Clinic , Nepean Hospital ( Penrith , NSW , Australia ) .
SETTING : Falls prevention clinic.
SETTING : Falls Unit , Complejo Hospitalario Universitario of Albacete ( Spain ) .
SETTING : Fifteen academic reproductive centers.
SETTING : Five community NHs.
SETTING : Five French cities including Amiens , Lyon , Montpellier , Paris and Toulouse.
SETTING : five primary care trust areas in England and their associated councils with social services responsibilities.
SETTING : Five university-based research centers.
SETTING : Florida AL facilities.
SETTING : Florida Alzheimer's Disease Research Center.
SETTING : Focus groups took place at three Group Health clinics in King County , Washington.
SETTING : Formal Dutch intellectual disability services and Dutch population-based study.
SETTING : For the home-living setting , home-dwelling elderly people from Hamburg , Germany who were participants in a prior study were included.
SETTING : Forty clinical centers in the United States.
SETTING : Four academic research centers.
SETTING : Four acute care hospitals in Canada.
SETTING : Four memory care practices within four healthcare systems in the greater Indianapolis area.
SETTING : Four memory clinics in the United States and Europe.
SETTING : Four NHs.
SETTING : Four U.S. centers.
SETTING : Framingham , Massachusetts.
SETTING : Framingham , Massachusetts.
SETTING : free-living elderly people of northwestern Spain.
SETTING : French community dwellers aged @number@ or over reporting subjective memory complaints , but free from clinical dementia.
SETTING : Functional Neuroimaging Unit , University of Montreal Geriatric Institute.
SETTING : \ "Gait , cOgnitiOn & Decline \ " ( GOOD ) initiative.
SETTING : Geisinger Rural Aging Study , Pennsylvania.
SETTING : General community.
SETTING : General community.
SETTING : General community.
SETTING : General community from two clinic sites in the United States ( Pittsburgh , Pennsylvania and Memphis , Tennessee ) .
SETTING : General community in Japan.
SETTING : General community in pre-designated zip code areas in Memphis , Tennessee , and Pittsburgh , Pennsylvania.
SETTING : general population of the city of Leiden , the Netherlands.
SETTING : General practices in the Netherlands.
SETTING : Geographically defined community in Chicago.
SETTING : Geriatric Assessment and Rehabilitation Unit ( GARU ) of a tertiary teaching hospital.
SETTING : Geriatric department of teaching hospital.
SETTING : Geriatric medicine outpatient clinic of a university hospital.
SETTING : Geriatric nursing home.
SETTING : Geriatric outpatient clinic of a university hospital.
SETTING : Geriatric rehabilitation patients , Sydney , Australia.
SETTING : Geriatrics memory clinic.
SETTING : Geriatric ward of a rural clinical hospital in Japan.
SETTING : Geriatric wards of a general hospital.
SETTING : German screening colonoscopy program.
SETTING : German state of Saarland.
SETTING : Godthaab Health and Rehabilitation Institution in Bærum , Norway.
SETTING : Greater metropolitan Chicago area.
SETTING : Greater New Haven , Connecticut.
SETTING : Greater Rochester , New York.
SETTING : Group Health and University of Washington , Seattle , WA , from @number@ to @number@
SETTING : Group training classes were held at a research center in Itabashi Ward , Tokyo , Japan.
SETTING : Health , Aging and Body Composition ( Health ABC ) Study.
SETTING : Health , Aging and Body Composition Study.
SETTING : Health , Aging and Body Composition Study.
SETTING : Health , aging , and body composition study performed in the USA.
SETTING : Health and Retirement Study.
SETTING : Healthy Aging in Neighborhoods of Diversity across the Life Span study.
SETTING : Healthy independent-living adults.
SETTING : Hertfordshire , UK.
SETTING : Hill's Pet Nutrition , Inc. dog colony.
SETTING : Home-assessment.
SETTING : Home-based assessment.
SETTING : Home-based rehabilitation ; measurements in university laboratory.
SETTING : Home-based treatment in patients recruited from outpatient clinics and from case-finding using general practitioners ' offices in the Amsterdam region.
SETTING : Home , senior center.
SETTING : Home settings in southern Sweden.
SETTING : Homes of community-dwelling older adults.
SETTING : Hong Kong , People's of Republic of China.
SETTING : Hospital.
SETTING : Hospital- and community-based older people were recruited in the region of Chongqing , China.
SETTING : Hospital based.
SETTING : Hospital-based spinal cord injuries unit.
SETTING : Hospital fertility center.
SETTING : hospital ( geriatric acute ward and transitional care of IRCCSS AUO San Martino Hospital , Genoa , Italy ) .
SETTING : Hospital , rehabilitation , nursing home , community.
SETTING : Hospital rehabilitation unit.
SETTING : hospitals and nursing care facilities.
SETTING : Hospitals and nursing homes.
SETTING : Hospitals , home , and long-term care.
SETTING : Hospitals participating in the American College of Surgeons National Surgical Quality Improvement Program.
SETTING : Human Brain Physiology Laboratory , Johns Hopkins Medical Institutions.
SETTING : Human Performance Laboratory , University setting.
SETTING : ICUs of two teaching hospitals in Paris area , France.
SETTING : Individuals in old age were recruited via general practitioners ' offices ( at six study centers ) in Germany.
SETTING : Individuals were recruited at the Memory Clinic , Queen Mary Hospital , Hong Kong.
SETTING : In Dordogne and Gironde , South Western France.
SETTING : Infertility clinic.
SETTING : Inhabitants of Ommoord , Rotterdam , The Netherlands.
SETTING : In-home assessment for cognitive impairment and self-administered caregiving questionnaire.
SETTING : Inpatient rehabilitation units and facilities contributing to the Uniform Data System for Medical Rehabilitation from the United States.
SETTING : Inpatient wards as well as ambulatory and emergency units run by a Brazilian university.
SETTING : In-person household interviews.
SETTING : Institute of Gastroenterology , Kaplan Medical Center , Rehovot , Israel.
SETTING : Intermediate care unit of the Intensive Medicine Service of the São João Hospital Center , Porto , Portugal.
SETTING : intervention at outpatient's clinic.
SETTING : Intervention in the participants ' homes after discharge from hospital.
SETTING : Interviews in homes or workplaces or by telephone.
SETTING : Interviews were conducted in participants ' homes.
SETTING : In two experiments a delayed letter recognition task was performed in a @number@.5T scanner at @time@ after two nights of total SD.
SETTING : John A. Moran Eye Center , University of Utah , Salt Lake City , Utah , USA.
SETTING : John Sealy Hospital at the University of Texas Medical Branch , Galveston , TX.
SETTING : Karolinska Institutet , Stockholm , Sweden.
SETTING : Kashiwa-city , Chiba-prefecture in Japan.
SETTING : Kinesiotherapy program for seniors with AD , São Paulo State University.
SETTING : Kungsholmen cohort , Stockholm , Sweden.
SETTING : Kungsholmen , Stockholm , Sweden.
SETTING : Laboratory.
SETTING : Laboratory.
SETTING : Laboratory.
SETTING : Laboratory of Inflammation Biology and Surgical Science and multi-institution level @number@ trauma centers.
SETTING : Landline and cellular telephone survey.
SETTING : Large academic hospital.
SETTING : Large multicenter study in the United States.
SETTING : Large multicentre study in the United Kingdom.
SETTING : Large , national hospice provider.
SETTING : Lifestyle Interventions and Independence in Elder ( LIFE ) Study.
SETTING : Local community.
SETTING : Lod , a town in the central Israel.
SETTING : Longitudinal Aging Study Amsterdam ; population-based , in three regions in The Netherlands.
SETTING : Long-term geriatric wards , in Reims , France.
SETTING : Los Angeles community.
SETTING : Male infertility specialty clinic.
SETTING : Manhattan ( broader area ) .
SETTING : Manitoba Study of Health and Aging.
SETTING : Mayo Clinic Study of Aging ( Olmsted County , MN ) .
Setting Medical center.
SETTING : Medical center.
SETTING : Medical ICU at an urban , academic medical center.
SETTING : Medical , surgical , and progressive ICUs of three academic hospitals.
SETTING : Medicare beneficiaries in the National Cardiovascular Data Registry-ICD Registry.
SETTING : Members of the Danish SCI Association.
SETTING : memory clinic and geriatric unit.
SETTING : Memory clinic in a rural part of the Netherlands.
SETTING : Memphis , Tennessee , and Pittsburgh , Pennsylvania.
SETTING : Memphis , Tennessee and Pittsburgh , Pennsylvania.
SETTING : Metropolitan-based health care system.
SETTING : Michael E. DeBakey VA Medical Center and Baylor College of Medicine.
SETTING : MOW , Forsyth County , North Carolina.
SETTING : Multicenter , international clinical trials.
Setting : Multicenter randomized trial in Spain.
SETTING : Multicenter trial , university medical centers.
SETTING : Multicenter university-based clinical practices.
SETTING : Multicenter U.S. institutions participating in the LIFE-P trial.
SETTING : Multiple communities.
SETTING : Multiple institutions that were members of international PRACTICAL consortium.
SETTING : Municipal registries in three Dutch regions.
SETTING : National Alzheimer's Coordinating Center from @number@ through @number@
SETTING : National Health and Aging Trends Study , 2011-2015.
SETTING : National Health and Nutritional Examination Survey ( @date@ ) .
SETTING : National Health and Nutrition Examination Surveys ( 2001-2002 ) .
SETTING : National hospital discharge survey datasets , 1980-2010 , United States.
SETTING : National Institute of Aging network of Alzheimer's Disease Centers.
SETTING : National Institute on Aging Intramural Research Program Clinical Research Unit at Harbor Hospital , Baltimore , Maryland.
SETTING : National Institute on Aging , Intramural Research Program , Clinical Research Unit , Baltimore , Maryland.
SETTING : National Institute on Aging Intramural Research Program Clinical Research Unit in Baltimore , Maryland.
SETTING : Nationally representative study from England.
SETTING : National Survey of Physical Fitness and Physical Activity , Portugal.
SETTING : Nationwide , older population-based Longitudinal Aging Study Amsterdam ( LASA ) .
SETTING : Nationwide study in Denmark.
SETTING : Naval Medical Research Institute.
SETTING : NCODE operates in a naturalistic treatment milieu.
SETTING : Nested cross-sectional study.
SETTING : Netherlands Study of Depression in Older Persons ( NESDO ) .
SETTING : Neurobehavioral Diseases Outpatient Clinic , Clinical Hospital , Ribeirao Preto Medical School ( University of São Paulo ) .
SETTING : Newcastle and North Tyneside , United Kingdom.
SETTING : Newcastle-upon-Tyne , United Kingdom ; Leiden , the Netherlands ; and Lakes and Bay of Plenty District Health Board areas , New Zealand.
SETTING : New Haven , Connecticut.
SETTING : New South Wales ( Australia ) retirement village.
SETTING : NHs in Texas.
SETTING : NIA.
SETTING : Nine French university teaching hospitals.
SETTING : Nine memory clinics around Australia.
SETTING : Nine residential aged care facilities and two geriatric / rehabilitation units in Southeast Queensland , Australia.
SETTING : Non-institutionalised elderly patients in Denmark.
SETTING : Noninstitutionalized community dwellers.
SETTING : Non-institutionalized persons in the United States participating in the National Health and Nutrition Examination Surveys III and its linked mortality dataset.
SETTING : Non-institutionalized Spanish elderly participating in the EXERNET multi-centre study.
SETTING : North central Alabama.
SETTING : Northern Italy.
SETTING : Northern Manhattan ( Washington Heights , Hamilton Heights , and Inwood ) .
SETTING : North Shore City , Auckland , New Zealand.
SETTING : Northwest Sydney.
SETTING : Not applicable.
SETTING : @number@ academic primary care clinics.
SETTING : @number@ general medicine units in an academic medical center.
SETTING : @number@ geriatric health care settings ( GHCSs ) , long term care and rehabilitation care settings in France.
SETTING : @number@ geriatrics units in the @number@ Teaching Hospitals of Paris-Sud ( APHP ) , France.
SETTING : @number@ Medicare Advantage plans.
SETTING : @number@ National Health and Aging Trends Study and National Study of Caregiving.
SETTING : @number@ National Health and Aging Trends Study and National Study of Caregiving.
SETTING : @number@ NHs in the greater Boston area.
SETTING : @number@ randomly selected administrative communities in Gironde and Dordogne ( France ) .
SETTING : @number@ university-affiliated primary care clinics.
SETTING : Nurses ' Health Study.
SETTING : Nursing home.
SETTING : Nursing home in Pavia , Italy.
SETTING : Nursing home located in the territory of Florence ( Italy ) .
SETTING : Nursing homes.
SETTING : Nursing homes.
SETTING : Nursing homes.
SETTING : Nursing homes in eight states ( @number@ facilities ) .
SETTING : Oak Hammock at the University of Florida , a nursing home located in Gainesville , Florida.
SETTING : Obira , Hokkaido , Japan.
SETTING : Observational and interventional studies.
SETTING : Odense Androgen Study-the effect of Testim and training in hypogonadal men.
SETTING : Older Adult Acute Psychiatric Inpatient Unit at the University of Maryland Medical Center from 10 / @date@ / 2010.
SETTING : Older adults enrolled in the Invecchiare in Chianti Study.
SETTING : Olmsted County , MN.
SETTING : Olmsted County , MN.
SETTING : One academic medical center and @number@ SNFs.
SETTING : One clinical site.
SETTING : One community pharmacy at Sabugal ( Portugal ) .
SETTING : One NH.
SETTING : One tertiary care medical center and eight postacute care sites.
SETTING : Open-access endoscopy within an academic hospital.
SETTING : Operating room in an academic health center.
SETTING : Operating room of an academic hospital.
SETTING : Originally a community sample of elementary school students in Victoria , Australia.
SETTING : Otopathology laboratory in a tertiary academic medical center.
SETTING : Outpatient clinic.
SETTING : Outpatient clinic for older people ( ≥75 years ) with diabetes.
SETTING : Outpatient clinic in Taiwan.
SETTING : Outpatient clinic of the Department of Cardiovascular , Respiratory , and Geriatric Medicine Kyushu University Hospital at Beppu in Japan.
SETTING : Outpatient clinics in two US tertiary care centers.
SETTING : Outpatient hospital-based Milan Geriatrics 75 + Cohort Study.
SETTING : Outpatient oncology clinics in seven academic medical centers.
SETTING : Outpatient rehabilitation clinics.
SETTING : Outpatient research at the Massachusetts General Hospital.
SETTING : Outpatient setting.
SETTING : Participants ' daily environment.
SETTING : Participants ' homes.
SETTING : Participants ' homes in Philadelphia region.
SETTING : Participants ' homes or apartments in southern California.
SETTING : Participants in the Nurses ' Health Study and the Health Professionals Follow-up Study , United States.
SETTING / PARTICIPANTS : @number@ community-dwelling , undernourished men and women aged > 65 years from South Australia , Victoria and New South Wales.
SETTING & PARTICIPANTS : @number@ consecutive Chinese patients with anti-GBM disease diagnosed in 1998-2008 in our tertiary referral center.
SETTING & PARTICIPANTS : @number@ participants @number@ years and older were recruited from arseniasis-endemic areas in northeastern Taiwan.
SETTING & PARTICIPANTS : @number@ prevalent hemodialysis patients.
SETTING / PARTICIPANTS : We conducted a mail-in survey targeting @number@ adults aged 50-65 in @number@ cities in Japan , and @number@ persons responded.
SETTING : Participants were recruited during a health screening examination by their general practitioners.
SETTING : Participants were recruited from the German federal state of Saarland.
SETTING : Participants were recruited from the Kahrizak Charity Foundation ( KCF ) .
SETTING : Participants were recruited from urban communities at @number@ field centers in Boston MA USA and Stockholm SWE.
SETTING : Patients admitted to a tertiary university hospital for acute hip fracture.
SETTING : Peking University People's Hospital , Beijing , China.
SETTING : Peripheral Geriatric Hospital.
SETTING : Pharmaceutical care discussed at home.
SETTING : Philadelphia region.
SETTING : Philadelphia senior center.
SETTING : Physicians ' Health Study participants.
SETTING : Pittsburgh , Pennsylvania , and Memphis , Tennessee.
SETTING : Population-based.
SETTING : Population-based cohort in England.
SETTING : Population-based cohort of older individuals ( > 65 years ) free of liver disease.
SETTING : Population-based cohort ( Singapore Longitudinal Ageing Study , SLAS ) .
SETTING : Population-based cohort study.
SETTING : Population-based cohort study in Olmsted County , MN.
SETTING : Population-based cohort study in Tokyo , Japan.
SETTING : Population-based cohort study of Denmark , Finland , Norway and Sweden.
SETTING : Population-based sample.
SETTING : Population-based sample from @number@ U.S. communities.
SETTING : population-based sample of community-dwelling older persons.
SETTING : Population-based study of three communities in the Chicago area.
SETTING : Population-based study on the incidence and prevalence of cognitive impairment in Olmsted County , Minnesota.
SETTING : Population-based three-city study.
SETTING : Population base , From \ "Aging in Leganes \ " cohort.
SETTING & POPULATION : Patients with CKD and caregivers.
SETTING : Population-representative sample.
SETTING : Population survey in Adelaide , South Australia.
SETTING & POPULATION : This analysis used data from the ACHIEVE trial , in which patients received either Cinacalcet-D or Flex-D.
SETTING : Post ward-rehabilitation.
Setting - Primary Care.
SETTING : Primary care chart registry sample.
SETTING : Primary care clinics affiliated with a safety net urban health care system in Indianapolis , Indiana , USA.
SETTING : Primary care clinics at a Veterans Affairs Medical Center.
SETTING : Primary care clinics in Indianapolis , Indiana.
SETTING : Primary care Lleida ( Spain ) .
SETTING : Primary care practices in England ( Clinical Practice Research Datalink ) .
SETTING : Primary health-care centres in Jaen , Spain.
SETTING : Private assisted reproductive technology clinic , synchrotron beam line , and university infrared laboratory.
SETTING : : prospective cohort analysis within the European Male Ageing Study.
SETTING : Prospective community-based cohort study.
SETTING : Prospective , serially assessed cohort of community-dwelling subjects.
SETTING : Province of Quebec , Canada.
SETTING : Public health system.
SETTING : Public hospital system.
SETTING : Public Primary Health Care Unit in a municipality in the Brazilian State of Sao Paulo.
SETTING : Quaternary referral center.
SETTING : Randomly sampled United States communities.
SETTING : Rehabilitation hospital.
SETTING : Relevant studies were identified by a search of PubMed and the Cochrane Library to @date@ , without language restrictions.
SETTING : Representative districts of Bangui ( Central African Republic ) and Brazzaville ( Republic of Congo ) .
SETTING : Republic of Ireland.
SETTING : Research centre and participants ' homes.
SETTING : Research Centre in Physical Activity , Health and Leisure , Faculty of Sport , University of Porto.
SETTING : Research clinic within a community.
SETTING : Research laboratory in a general hospital.
SETTING : Research sleep laboratory affiliated with a University hospital.
SETTING : Residential Aged Care Facilities.
SETTING : Residential care facilities and private dwellings in Australia.
SETTING : Residential homes , day care centres , nursing homes and institutions.
SETTING : Retirement communities across metropolitan Chicago.
SETTING : Retirement communities , senior housing facilities , and homes across the greater Chicago metropolitan area.
SETTING : Retirement home in Antalya , Turkey.
SETTING : Rotman Research Institute , Baycrest Health Sciences.
SETTING : Rotterdam Ophthalmic Institute , Rotterdam , the Netherlands.
SETTING : Rural Midwestern United States.
SETTING : Saarland , Germany.
SETTING : Salisbury , Maryland.
SETTING : San Antonio , Texas , neighborhoods.
SETTINGS AND PARTICIPANTS : Frail residents in four nursing homes with a Clinical Frailty Scale score ≥5 ( median 7±0 ) .
SETTINGS AND PARTICIPANTS : @number@ healthy men and women aged between @number@ and @number@ years recruited through consumer's database.
SETTINGS AND PARTICIPANTS : Participants were last-semester student nurses from @number@ universities offering nursing undergraduate programs in Shandong , China.
SETTING : Sanitary and Health Care Section of Yuan Ze University in Taiwan.
SETTING : São Paulo , Brazil.
SETTINGS : A teaching hospital in Kuala Lumpur , Malaysia.
SETTING : SCI Model Systems.
SETTING : SCI Model Systems and Shriners Hospital SCI units.
Settings community samples ( n = @number@ @number@ ) from @number@ world regions ( Latin America , China , and India ) .
SETTINGS : Department of Orthodontics , Faculty of Dentistry , Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.
SETTING : Seattle , Washington , USA.
SETTING : Secondary analysis of data from the Beijing Longitudinal Study on Aging.
SETTING : Secondary hospitals.
SETTING : Seven LTC facilities in the province of Quebec , Canada.
SETTING : Seven nursing homes.
SETTING : Seven public nursing homes.
SETTING : Seventy-three community-based LTC facilities in northern Taiwan.
SETTINGS : Four general hospitals in the Netherlands and four general hospitals in the USA.
Setting should be taken into consideration in studies for validation of GFR equations.
SETTING : Single center , @number@ bed community teaching hospital.
SETTING : Single-center study conducted at a Veterans Affairs Healthcare System.
SETTING : Single clinical reference laboratory.
SETTING : Single primary care addiction clinic in Brisbane , Australia.
SETTING : Six annual examinations in four U.S. communities.
SETTING : Six churches in North Florida.
SETTING : Six clinical sites participating in the Osteoporotic Fractures in Men ( MrOS ) Study.
SETTING : Six different municipal residential homes in the south-east of Sweden.
SETTING : Six French nursing homes or other institutions for elderly.
SETTING : Six hospital sites ( five public , one private ) .
SETTING : Six U.S. cities.
SETTING : Six U.S. sites.
SETTING : Sleep laboratory.
SETTING : Sleep laboratory.
Setting : Sleep laboratory at Emory University School of Medicine.
SETTING : Sleep laboratory in a university hospital.
SETTING : Sleep laboratory studies conducted from 2001-2011.
SETTING : Sleep research center.
SETTINGS : Nine university hospitals in France.
SETTING : Social Neuroscience Laboratory.
SETTING : Socioeconomically and ethnically diverse neighborhoods in San Antonio , Texas.
SETTING : Socioeconomically diverse neighborhoods in San Antonio , Texas.
SETTING : Socioeconomically diverse neighborhoods in San Antonio , Texas.
SETTING : Southeast of England , UK.
SETTING : Southern California community.
SETTING : Southern California community.
SETTING : South Korea.
SETTINGS : Six sites in the United States.
SETTING : Standardized in-person home interviews.
SETTING : Standardized , in-person home interviews and physical performance testing.
SETTINGS : The Longitudinal Aging Study Amsterdam ( LASA ) , the Netherlands.
SETTINGS : The study was carried out in seven Italian nursing schools.
SETTINGS : three respiratory units.
SETTING : St. Michael ' s Hospital , Toronto , ON , Canada.
SETTING : Studies from multiple countries were included.
SETTING : Study data is based upon the Italian Longitudinal Study on Aging ( ILSA ) a prospective , community-based cohort study.
SETTING : Study data were obtained from detailed interviews conducted in the home or by telephone.
SETTING : Study of Osteoporotic Fractures ( SOF ) .
SETTINGS : university campus and community-based halls.
SETTINGS : University of Alexandria.
SETTING : Surgical or burn ICU.
SETTING : Surveillance , Epidemiology , and End Results cancer data linked with Medicare claims.
SETTING : Survey participants were non-institutionalized.
SETTING : Surveys were mailed to community-dwelling individuals who had @number@ of @number@ diagnoses ( MS , MD , PPS , or SCI ) .
SETTING : Swedish Dementia Registry ( SveDem ) , 2007-2012.
SETTING : Taiwan.
SETTING : Taiwan Longitudinal Study in Aging from @number@ @number@ @number@ @number@ and @number@
SETTING : Taiwan's National Health Insurance claims data.
SETTING : Teaching geriatric unit.
SETTING : Tehran Lipid and Glucose Study , university center.
SETTING : Tertiary academic Alzheimer's Disease Centers funded by the National Institute on Aging.
SETTING : Tertiary academic referral center.
SETTING : Tertiary and university hospital.
SETTING : Tertiary and University Hospital.
SETTING : Tertiary care , academic medical center.
SETTING : Tertiary medical center.
SETTING : Tertiary referral center.
SETTING : Tertiary referral center.
SETTING : Tertiary referral center , primarily ambulatory setting.
SETTING : Tertiary referral hospital.
SETTING : Tertiary teaching hospital in Western Australia.
SETTING : Texas , New Mexico , Colorado , Arizona , and California.
SETTING : The Aging , Demographics , and Memory Study.
SETTING : The Aging , Demographics , and Memory Study ( ADAMS ) .
SETTING : The Baltimore Memory Study , a population-based sample of older urban residents.
SETTING : The Bambuí ( Brazil ) Cohort Study of Aging.
SETTING : The Bambui-Epigen ( Brazil ) Cohort Study of Aging.
SETTING : The Basel Memory Clinic and the Basel Study on the Elderly ( Project BASEL ) .
SETTING : The biomechanical laboratory in a tertiary hospital.
SETTING : The center laboratory and the Department of Otolaryngology-Head & Neck Surgery , Beijing Tongren Hospital.
SETTING : The CF and dermatology clinics at St Louis Children's Hospital.
SETTING : The cohort was recruited from the general population.
SETTING : The dietary intake was studied in elderly people living at home or in nursing home , in different cities of Sweden.
SETTING : The ED of the Children's Hospital at Westmead , Australia.
SETTING : The European Male Aging Study.
SETTING : The Framingham Offspring Study.
SETTING : The French national gas and electricity company.
SETTING : The Hatoyama Cohort Study and Kusatsu Longitudinal Study , Japan.
SETTING : The Health , Aging , and Body Composition Study.
Setting : The Health and Retirement Study.
SETTING : The Health and Retirement Study , a nationally representative survey of community-living older adults ( @number@ to @number@ ) .
SETTING : The Helsinki Businessmen Study in Finland.
SETTING : The Hunter New England ( HNE ) region of New South Wales ( NSW ) , Australia.
SETTING : The ICTUS study is a prospective , naturalistic observational study conducted in specialised memory clinics in @number@ European countries.
SETTING : The island of Crete ( rural areas and the city of Heraklion ) .
SETTING : The Knight Alzheimer's Disease Research Center , Washington University at St. Louis.
SETTING : The Kolpino district of St. Petersburg.
SETTING : The Madrid region , Spain.
SETTING : The Modified Delphi process was conducted online using survey software.
SETTING : The National Social Life , Health , and Aging Project.
SETTING : The Normative Aging Study , an ongoing cohort study of community-dwelling men in the Boston area.
SETTING : The @number@ U.S. population aged @number@ years and older.
SETTING : The Nurses ' Health Study , a cohort of registered nurses residing in @number@ US states.
SETTING : The participants were living in ordinary housing or special housing in Sweden.
SETTING : The physical examination center in Xuanwu Hospital , Capital Medical University in Beijing.
SETTING : The Physical Frailty in Elder Cancer patients ( PF-EC ) study ( France ) .
SETTING : The Pilot Coordination Unit in Geriatric Oncology of Côte d'Or , Burgundy , France.
SETTING : The preventive medical center ( CMP ) in Nancy.
SETTING : The programme participants were in one underserved neighbourhood in Birmingham , Alabama , an urban city in the south-eastern USA.
SETTING : The program took place at the Massachusetts General Hospital ( MGH ) .
SETTING : The PROOF study , including @number@ elderly community residents.
SETTING : The Rosa Parks Geriatric Center at Detroit Medical Center / Wayne State University.
SETTING : The sample was drawn from seven towns and cities across Japan.
SETTING : The sample was drawn from seven towns and cities across Japan.
SETTING : The sample was selected among community-dwelling older people from the city of Ribeirão Preto / Brazil.
SETTING : The Save Hearts in Arizona Registry ( SHARE ) .
SETTING : The setting for the study was the Korean and US population.
SETTING : The setting was a community-based observational cohort.
SETTING : The Singapore Longitudinal Aging Studies ( SLAS ) , a community-based study in urban region of Singapore.
SETTING : The Singapore Longitudinal Aging Study ( SLAS ) .
SETTING : The single center study in Seoul , Republic of Korea.
SETTING : The study occurred in Nursing homes and hospitalised settings.
SETTING : The study took part in a laboratory setting.
SETTING : The study took part in a laboratory setting.
SETTING : The study took place in Hamburg , Germany and made use of health care structures and professionals of a geriatrics centre.
SETTING : The study was conducted at a tertiary referral center.
SETTING : The study was conducted at a university hospital in the city of Leiden , The Netherlands.
SETTING : The study was conducted at @number@ sites in the United States.
SETTING : The study was conducted at primary care practices in @number@ countries.
SETTING : The study was conducted at two institutional research centers.
SETTING : The study was conducted between @date@ and @date@ in a tertiary 1002-bed university hospital.
SETTING : The study was conducted in a laboratory.
SETTING : The study was conducted in a tertiary referral center.
SETTING : The study was conducted in independent-living women in the midwest United States.
SETTING : The study was conducted with community-dwelling volunteers participating in the Baltimore Longitudinal Study of Aging.
SETTING : The study was nested within the AGES-Reykjavik Study , conducted in Reykjavik , Iceland.
SETTING : The study was performed in the acute geriatric medicine wards of the Prince of Wales Hospital , Sydney Australia.
SETTING : The study was set in an academic spine center.
SETTING : The Survey of Health , Ageing and Retirement in Europe ( SHARE ) .
SETTING : The Taiwan Longitudinal Study on Aging is a nationwide prospective cohort study comprising a representative random sample of middle-aged and older adults.
SETTING : The Third National Health and Nutrition Survey ( NHANES III ; 1988-1994 ) .
SETTING : The Toledo Study for Healthy Aging , Spain.
SETTING : The Treviso Longeva ( Trelong ) study , in Treviso , Italy.
SETTING : The Tromsø Study ( TS ) is a cohort study using a survey approach with repeated physical examinations.
SETTING : The University of Texas Medical Branch , Clinical Research Center , Galveston , Texas.
SETTING : The Veterans Aging Cohort Study ( VACS ) , at eight VA Medical Centers nationally.
SETTING : The Washington Heights-Inwood Columbia Aging Project and the Estudio Familiar de Influencia Genetica de Alzheimer study.
SETTING : Third National Health and Nutritional Examination Survey ( 1988-1994 ) .
SETTING : thirteen European countries representing four welfare regimes ( Southern , Scandinavian , Post-communist and Bismarckian ) .
SETTING : Thirteen health examination centres in Eastern France.
Setting : Thirteen prospective cohort studies with baseline examinations between @number@ and @number@
SETTING : Thirty-five of @number@ prefectures in Japan.
SETTING : Thirty-one hospitals that perform gastrostomy insertion , replacement and management.
SETTING : Thirty-one NHs in Southeastern United States.
SETTING : Thirty-three community pharmacies in the North of England.
Setting : This study was conducted at the Veterans Health Administration ( VA ) .
SETTING : This study was conducted in a large county hospital in western Sweden.
Setting : This study was conducted in Beijing , China.
SETTING : This study was performed in nursing homes.
SETTING : This was a multicenter study with samples from @number@ cohorts from the United States , Canada , and Europe.
SETTING : This was a population-based study of healthy volunteers.
SETTING : Three academic centers.
SETTING : Three acute care public hospitals in two Australian states.
SETTING : Three areas in Sweden : Municipality of Nordanstig , Stockholm and Skåne County.
SETTING : three care homes in the United Kingdom.
SETTING : Three clinical research centers in the Midwest and on the West Coast and East Coast.
SETTING : Three community settings in Japan from autumn to winter.
SETTING : Three elderly homes in Cairo , Egypt.
SETTING : three geographical areas of the United Kingdom.
SETTING : three healthcare settings in one town.
SETTING : Three health centers in Japan.
SETTING : Three health centers in North-East of France.
SETTING : Three large urban nursing homes within a long term care system in New York State.
SETTING : Three Los Angeles churches.
SETTING : Three North Island locations in New Zealand.
SETTING : Three North Island locations ( rural and urban areas ) in New Zealand.
SETTING : Three Ontario emergency departments.
SETTING : Three primary care sites in southern California.
SETTING : Three primary care sites in southern California.
SETTING : three specialist elderly care wards in a general hospital.
SETTING : Three urban ambulatory care practices at Boston Medical Center between @date@ and @date@ .
SETTING : Three urban communities in the United States.
SETTING : Three US clinical sites.
SETTING : TILDA participants were community dwelling only while IDS-TILDA participants were drawn from community and institutional settings.
SETTING : Tokyo Dental College , Suidobashi Hospital , Tokyo , Japan.
SETTING : Toronto , Ontario and Vancouver , British Columbia , Canada.
SETTING : Treadmill in the animal house.
SETTING : TREAT was based in the Accident and Emergency ( A & E ) department of the Royal Free Hospital , London.
SETTING : Tsurugaya district , Sendai , Japan.
SETTING : Tuscany , Italy.
SETTING : Tuscany , Italy.
SETTING : Twelve contiguous ZIP code areas in Baltimore , Maryland.
SETTING : Twelve outpatient clinics in the San Francisco Bay area.
SETTING : Twenty-four nursing homes ( NHs ) .
SETTING : Twenty-two Boston-area NHs.
Setting : Two academic centers.
SETTING : Two academic medical centers.
SETTING : Two academic medical centers.
SETTING : Two academic medical centers.
SETTING : Two acute medical female wards in a university hospital in England.
SETTING : Two care facilities in Gelderland , the Netherlands : a residential care home and a rehabilitation center.
SETTING : Two community-based social and clinical networks.
SETTING : Two counties in Iowa ; a part of the Established Populations for Epidemiologic Study of the Elderly.
SETTING : Two GEM units at St Vincent's Hospital Melbourne , Australia.
SETTING : Two homecare organizations in the Netherlands.
SETTING : Two NHs in North Carolina.
SETTING : Two primary care clinics in the San Francisco Bay area.
SETTING : Two tertiary hospitals in Boston , Massachusetts.
SETTING : Two U.S. clinical centers.
SETTING : Two U.S. clinical sites.
SETTING : United Kingdom infertility clinics.
SETTING : United States.
SETTING : United States.
SETTING : United States.
SETTING : United States , 2000-2006.
SETTING : United States , @date@ .
SETTING : Universidade Estadual Paulista , Botucatu Medical School , São Paulo State University ( UNESP ) , Brazil.
SETTING : University-affiliated reproductive medicine unit.
SETTING : University andrology and research laboratory.
SETTING : University balance laboratory.
SETTING : University clinic.
SETTING : University hospital.
SETTING : University hospital.
SETTING : University hospital.
SETTING : University hospital.
SETTING : University hospital from @date@ to @date@ .
SETTING : University medical center.
SETTING : University medical center.
SETTING : University medical center balance disorder laboratory.
SETTING : University neuromuscular and neurogenetics and magnetic resonance imaging units.
SETTING : University of California at Los Angeles Department of Medicine Community Offices and Primary Care Network.
SETTING : University of California San Diego and the Veterans Administration San Diego Healthcare System.
SETTING : University of Michigan Health System , a 930-bed tertiary care hospital.
SETTING : University of Pittsburgh , Pittsburgh , Pennsylvania.
SETTING : University of Washington Medical Center from 2001-2006.
SETTING : University research facility.
SETTING : University research laboratory.
SETTING : University research laboratory.
SETTING : University research laboratory.
SETTING : University teaching center.
Setting up a nationwide system for continuous monitoring of stroke costs is feasible.
SETTING : Uppsala Longitudinal Study of Adult Men , Sweden.
SETTING : Urban academic hospital that serves as a safety net for urban and rural populations with low resources and serves central and northern Alabama.
SETTING : Urban and rural counties of central North Carolina.
SETTING : Urban and rural households in the Southwestern United States.
SETTING : Urban area of Stockholm , Sweden.
SETTING : Urban neighborhoods in Washington , DC , USA.
Setting : Urban public health system.
SETTING : Urban tertiary care hospital and community hospital.
SETTING : Urology , urogynaecology , and primary care offices / clinics.
SETTING : US clinical centers.
SETTING : U.S. hospice and PC programs from the National Hospice and Palliative Care Organization's program list.
SETTING : US Medicare- and Medicaid-certified nursing homes , @number@ to @number@
SETTING : US Medicare insurance claims data linked to rainfall data from US weather stations.
SETTING : US non hospital and hospital based clinics.
SETTING : US population.
SETTING : US primary care , internal medicine , orthopaedic and rheumatology practices.
SETTING : VA Healthcare System.
SETTING : VA medical centers in the United States.
SETTING : Vancouver Falls Prevention Clinic , Canada ( www.fallsclinic.ca ) .
SETTING : Veterans Affairs Dental Longitudinal Study in greater Boston , Massachusetts , area.
SETTING : Veterans Affairs Maryland Health Care System ( VAMHCS ) .
SETTING : Veterans Affairs Medical Center , Durham , North Carolina.
SETTING : Veterans Affairs Medical Center , Houston , TX.
SETTING : Veterans Affairs Medical Center ( VAMC ) EDs.
SETTING : Veterans Health Affairs inpatient and outpatient settings.
SETTING : Wake Forest School of Medicine , Winston-Salem NC @number@ USA.
SETTING : Web-based platform.
SETTING : Weill-Cornell Advanced Center for Interventions and Services Research.
SETTING : We recruited @number@ residents with limited ability to communicate.
SETTING : West of Scotland.
SETTING : Wishard Health Services senior care and community mental health clinics.
SETTING : Women Cognitive Impairment Study of Exceptional Aging.
SETTING : Women's Health and Aging Studies II ( WHAS-II ) , Baltimore , Maryland.
SETTING : Women's Health Initiative ( WHI ) Clinical Trials ( CT ) and Observational Study ( OS ) conducted at @number@ clinical centers.
SETTTING : area assisted by the Family Health Program of the Ribeirão Preto Medical School , University of São Paulo , Brazil.
Seven additional variants were associated ( P < 0.05 ) with ER-positive disease.
Seven age groups ( AgGr ) between @number@ and @number@ years were designed.
Seven age groups were designed , from @number@ to @number@ years.
Seven age groups were divided by decades ranging from @number@ to @number@ years to @number@ + years.
Seven agencies delivered @number@ CDSMP workshops at @number@ sites from @date@ , to @date@ .
Seven articles on @number@ RCTs involving @number@ participants were included.
Seven buildings had the SAH program and four did not.
Seven cases , in which the primates were administered Am citrate by intravenous injection , were evaluated using the ICRP @number@ systemic model.
Seven-day accelerometry was used to assess total physical activity , moderate-to-vigorous activity and sedentary time.
Seven days after CR treatment , all female mice were caged with male mice until pregnancy was verified.
Seven groups included patients ( n = 38 ) , aged ≥65 years , who reported making serious medical decisions.
Seven healthy volunteers ( mean age @number@ years ) participated in this study.
Seven independent risk factors for a perioperative MACE were identified.
Seven major scientific databases ( including MEDLINE , Scopus and CINAHL ) were searched.
Seven normal transparent human lens nuclei were obtained from fresh normal cadaver eyes during corneal transplantation surgery.
Seven of @number@ patients had CT scans prior to developing CSDH.
Seven of the @number@ included studies provided test-retest coefficients , and these were used in the meta-analyses of test-retest reliability.
Seven of the patients had a previous facelift.
Seven of these treated patients are currently being followed and have good control of the disease.
Seven out of eight persons with mUPD had a history of psychiatric illness.
Seven out of eight subjects showed varying degree of improvement.
Seven out of @number@ used interaction databases.
Seven out of ten studies investigating cognition found comorbidities to be related to decreased cognitive performance.
Seven participants ( @percent@ ) completed ≥ @number@ hours of ACT.
Seven patients died , some of whom experienced severe plegic attacks or epileptic seizures at the time of death.
Seven patients had undergone coronary artery bypass surgery that requires prolonged operative time.
Seven patients required right ventricular assist device ( RVAD ) including @number@ patients converted to durable RVAD.
Seven ( @percent@ ) deaths were caused by CVD , including four cases of stroke and three cases of myocardial infarction.
Seven polymorphisms of IGF1 , IGFBP3 , and IGFBP5 were analyzed by using Illumina GoldenGate Genotyping Assay.
Seven PWD and their caregivers who spoke French as their primary language but who lived in a primarily English-speaking region completed the interviews.
Seven RCTs were included in our review.
Seven spatiotemporal gait parameters were collected with the GAITRite ( r ) system.
Seven spatiotemporal parameters were extracted and compared between the two groups.
Seven standard photographs from the Early Treatment for Diabetic Retinopathy Study were obtained from each eye after pharmacological pupil dilatation.
Seven stressful events were examined for which data were available in all cohorts.
Seven studies examined measures of muscle strength.
Seven studies examined optimal BP targets.
Seven studies , from @number@ previously selected ones , were identified according to the inclusion criteria.
Seven studies met our inclusion criteria , describing @number@ different CGAs that have been validated for nursing home residents with palliative care needs.
Seven studies met the selection criteria.
Seven studies ( @percent@ ) were found for the short-term outcome , and four studies ( @percent@ ) were found for the long-term outcome.
Seven studies were observational and @number@ were quasi-experimental.
Seven subjects ( @number@ male , @number@ female ) had RBD , three of whom ( @number@ male , @number@ female ) had Parkinson disease.
Seven subjects presented sacral sparing and improved American Spinal Injury Association impairment scale ( AIS ) grades to B or C - incomplete injury.
Seven subjects reported greater satisfaction with their overall facial appearance.
Seventeen candidate SNPs ( from @number@ genes / regions ) associated with neuroimaging phenotypes in prior studies showed no significant evidence of association.
Seventeen common LRRK2 exonic variants were genotyped and assessed for association with MSA.
Seventeen control subjects spanning @number@ decades underwent magnetic resonance imaging to assess age-related changes.
Seventeen eligible studies were included.
Seventeen healthy subjects , @number@ years and older , were recruited from the community.
Seventeen men ( mean ± S.D. age = @number@ ± @number@ yrs ) participated in this double-blinded , placebo-controlled , crossover study.
Seventeen older adults and seventeen young controls performed two-segment aiming movements.
Seventeen patients belonged to the moderate to high risk group for cardiovascular disease , whereas the remaining @number@ belonged to the low risk group.
Seventeen patients ( @time@ % ) presented with previous abdominal surgery , and @number@ patients ( @percent@ ) presented a medical history of urological surgery.
Seventeen patients with mild AD and @number@ healthy age-matched controls took part in the study.
Seventeen percent scored below the cutoff for cognitive impairment.
Seventeen studies were included in the review , including those related to literary , performing and visual arts.
Seventeen volunteers participated in the study.
Seven transgenic marmosets were produced by lentiviral introduction of the human ataxin @number@ gene with @number@ CAG repeats encoding an expanded polyQ stretch.
Seventy cases ( @percent@ ) were classified as ' idiopathic ' and @number@ ( @percent@ ) as ' others'.
Seventy cognitively intact adults ( 43-87 years ) completed a cued-trials task switching paradigm.
Seventy-eight articles were eligible , with @number@ arms and @number@ patients.
Seventy-eight older mixed-ethnicity adults ( age @number@ and older ) who were not culturally affiliated with TC were recruited for this study.
Seventy-five elderly participants were randomly assigned to one of the three groups : the comparison group , the cognitive-behavioural strategies with or without exercise group.
Seventy-five individuals with calcified NCC and their matched control subjects were included in the analysis.
Seventy-five participants were voluntarily enrolled in the exercise group.
Seventy-five percent of injectors found Voluma fairly / very easy to inject and @percent@ found it easy to sculpt / massage.
Seventy-five percent of patients had an organic disorder , @percent@ exhibiting psychotic symptoms.
Seventy-five percent of the respondents believe that the WHO-guidelines are not feasible for LTCF-residents.
Seventy five residents ( @percent@ ) were identified as affected by coexisting severe frailty and malnutrition.
Seventy four are alive worldwide , with twenty two in the United States.
Seventy-four of the @number@ fungal strains were selected for identification at the species level by using morphological criteria and internal transcribed spacers sequencing.
Seventy-four ( @percent@ ) individuals participated in the study.
Seventy-four subjects completed all study visits.
Seventy-nine older adults ( mean age @number@ ± @number@ ) wore an accelerometer at the lower back during two nonconsecutive weeks.
Seventy-nine percent of infections occurred within @number@ days postoperatively.
Seventy-nine studies met inclusion criteria.
Seventy-nine young and @number@ older adults continuously reported their moods while viewing emotional and neutral faces.
Seventy of these proteins exhibited an age-dependent secretion pattern and were accordingly denoted ' skin aging-associated secreted proteins ( SAASP ) '.
Seventy-one agreed to participate and were given a brochure along with a brief review of the materials it contained.
Seventy-one patients ( @number@ % ) died during the one-year follow-up.
Seventy-one patients were evaluated after varying energy ( mJ ) and density settings by superficial ablation , deeper penetration , and combined treatment.
Seventy participants ( @percent@ ) had cortical CMIs ( median , @number@ range , 0-43 ) .
Seventy percent of participants engaged in unprompted discussions about birth order and family dynamics.
Seventy percent of people in the United States who have dementia die in the nursing home.
Seventy per cent of the interventions were adaptive.
Seventy percent of the studies reported some brain regions in which greater activation related to better cognitive performance among older participants.
Seventy-seven Japanese American older adults participated in focus groups.
Seventy-seven of them ( @number@ younger adults , @number@ older adults ) underwent the same assessments @number@ to @number@ weeks later.
Seventy-seven patients ( @number@ prostheses ) had died before the 10-year follow-up , and @number@ patients ( @number@ prostheses ) had been lost to follow-up.
Seventy-six incident hip and @number@ incident nonvertebral fractures occurred over a median follow-up of @number@ years.
Seventy-three CHF males with New York Heart Association ( NYHA ) classes II and III and @number@ control subjects aged ≥ @number@ yr were recruited.
Seventy-three elderly patients with MD , unipolar and bipolar , were treated with a course of formula-based BF ECT or RUL ECT.
Seventy-three Meals on Wheels volunteers participated in workshops to train as health literacy coaches.
Seventy-three patients ( @percent@ women ) were recruited : @number@ with ischemic stroke and nine with haemorrhagic stroke.
Seventy-three patients with NPs , septal deviations and middle concha hypertrophies were recruited.
Seventy-three percent of children continued to meet ADOS cut-off at school age.
Seventy-three percent of included patients had respiratory and hemodynamic supports at renal replacement therapy initiation , similarly distributed across quintiles.
Seventy-three percent reported at least @number@ correct warning sign of stroke , whereas only @percent@ reported @number@
Seventy-two child and caregiver dyads completed clinician- and self-rated questionnaires.
Seventy-two occupants with moderate to severe ( AIS 2 + ) liver injuries were investigated.
Seventy-two of the subjects were characterized as nondemented throughout the study.
Seventy-two patients had a preoperative neurologic deficit and @number@ had a systemic morbidity before surgery.
Seventy-two retired workers admitted to hospitals after a fall were matched with @number@ controls from the same industrial sectors.
Seventy-two subjects ( 43 / 72 women , 38 / 72 with OSA ) were studied.
Seventy women ( @number@ Active group , @number@ Vehicle group ) completed the study.
Seven variables of interest were measured and analysed to identify morphologic alterations of the vertebral bodies in each QCMC category.
Seven waves of data from the Health and Retirement Study were analyzed for @number@ adult child caregivers using latent growth curve models.
Seven young and seven older participants walked both over-ground and on a treadmill to obtain the swing foot trajectory data.
Several active drugs regulate brain lipid signaling and provide proof of concept for targeting the brain.
Several additional alterations in many other genes have been established to either cause or increase the risk of parkinson disease.
Several ADRs are particularly associated with major adverse consequences in the elderly and their reduction is therefore a clinical priority.
Several adverse testing schemes simulating impingement showed satisfactory behaviour.
Several age-related diseases , such as Alzheimer's disease , and longevity have also been linked to the functions of sirtuins.
Several age-related traits are associated with shorter telomeres , the structures that cap the end of linear chromosomes.
Several aging studies have also reported an increase of gliosis as a function of normal aging.
Several agonists showed preference for activation of Gαs GTPase relative to βarr recruitment , and no βarr-biased ligand was identified.
Several analytical approaches to extract information from the EEG signal have been proposed.
Several anatomic and functional ophthalmological parameters are associated with increasing chronological age.
Several animal models have investigated the bone protective effects of RES supplementation.
Several animal models of atherosclerosis-induced chronic bladder ischemia are available and should be useful tools for further research.
Several antioxidant therapies and drugs affecting mitochondrial biogenesis are undergoing investigation , although not all of them have demonstrated favorable effects in the clinic.
Several approaches have been introduced to render the SABG assay quantitative.
Several approaches to infection prevention exist , including antimicrobial prophylaxis and decolonization.
Several approaches to retain the integrity of the hybrid layer and to improve the long-term dentin bond strength have been tested.
Several aspects of chronologic and biologic aging in the human choroid are reviewed from the literature.
Several aspects of the tracking process can influence performance.
Several aspects of wisdom were judged , including those related to cognitive skills , and those related to socioemotional aspects of wisdom.
Several attempts have been done to define ACOS on the basis of medical history , symptoms , and functional findings.
Several attempts to rescue the normal cellular phenotype with farnesyltransferase inhibitors ( FTIs ) and other compounds have resulted in partial cellular recovery.
Several autosomal dominant progranulin ( GRN ) mutations have been reported , accounting for 5%-10% of FTLD cases worldwide.
Several avenues for future research are suggested , including an exploration of the role played by internal sources of support.
Several bacterial taxa and metabolic modules ( biochemical functions ) have been associated with human health and the absence of disease.
Several biological findings have been associated with age-related disorders , including increased oxidative stress , inflammation , and telomere shortening.
Several brain regions , but not all , showed principally positive correlations between R2 values and age ; negative correlations emerged in the cerebellar peduncles.
Several candidate genes obtained through this analysis have been confirmed by functional experiments , thereby validating the experimental approach.
Several candidate tests have been proposed already , and no doubt others will be proposed in the future.
Several caregiver background characteristics were associated with care recipients ' depression and agitation , but not with other BPSD.
Several case-control studies have confirmed HPV as an independent risk factor for squamous cell carcinoma.
Several causes for this lack of efficacy can be given.
Several changes have been reported to occur in the cavernosal tissue and tunica albuginea with aging.
Several characteristics of aging and geriatrics medicine affect drug prescribing for elderly.
Several chemosensitizers reverse MDR but have significant toxicities.
Several circRNAs have been shown to function as microRNA \ "sponges \ " to counteract microRNA mediated repression of mRNA.
Several clinical features were evaluated and their possible association with MN frequency was tested.
Several clinical studies in healthy subjects show that consumption of wolfberry juice improves general wellbeing and immune functions.
Several clinical trials used randomisation and single-blindation to strengthen the validity of the study outcome.
Several clock genes were disrupted in the early stages of cartilage degeneration in the DMM mouse model of OA.
Several CNS disorders have been linked to the presence and severity of jugular venous reflux.
Several cohort studies in neonates with significant comorbidities requiring surgical procedures early in life have also demonstrated abnormal neurodevelopmental outcomes.
Several collaborative efforts toward discovery of low-frequency variants and copy number variation for BP traits are currently underway.
Several common categories of protein function were observed among genes ranked with the strongest associations with MLS identified by all regression models.
Several common genetic variants influence cholesterol levels , which play a key role in overall health.
Several common items with significant differences were observed in the mandibular measurements.
Several communication intervention studies have been conducted to improve communication between nursing home staff and nursing home residents with dementia.
Several competing companies are now promising flights for the general population.
Several compounds exhibited promising Aβ self-assembly and cholinesterase inhibition and in parallel , showed good free radical scavenging properties.
Several compounds inhibiting 11β-HSD1 at nanomolar concentrations were identified.
Several consensus definitions of sarcopenia exist , each providing different cut points and methodologies for assessing muscle mass and muscle strength.
Several correlations between sleep variables and neuropsychological tests were found.
Several cross-tabulations were computed to investigate culture and gender differences in most important life event domains.
Several cytokines and transcription factors are linked to autophagy and play an important role in the degradative cascade in osteoarthritis ( OA ) .
Several demographic and structural factors are associated with this variation.
Several demographic factors correlated with knowledge ; health literacy and numeracy were both important predictive variables.
Several demonstrated lack of benefit of statins among persons with end-stage renal disease.
Several demonstrated no difference or an increased risk of adverse outcome among persons with DM and tight control of HTN as compared to usual control.
Several dengue vaccines are under development , and some are expected to become available imminently.
Several diagnostic innovations were presented , such as some polymerase chain reaction techniques for use in gastric biopsy specimens or gastric juice.
Several diseases are known to have a multifactorial origin , depending not only on genetic but also on environmental factors.
Several DNA repair enzymes critical to the prevention of cutaneous malignancies have been isolated and added to topical preparations designed for skin cancer prevention.
Several domains differed between men and women and differed across age groups.
Several drug-disease interactions such as benzodiazepines and falls were cited in most criteria.
Several drugs in these groups are in phase III at the moment.
Several drugs targeting vascular endothelial growth factor signals are now in clinical use for anti-angiogenic cancer treatment.
Several equations are used to estimate kidney function.
Several evolutionarily conserved pathways that modulate lifespan have been identified in organisms ranging from yeast to primates.
Several examples are brain-penetrant and exhibit balanced multitargeted in vitro activity in the low μM range.
Several examples are highlighted in this review.
Several executive functions , among which the strategic retrieval ability , were evaluated.
Several exemplars of frailty scales that might serve this purpose are identified , and their potential contributions and limitations are discussed.
Several exogenous factors were significantly related to social disconnectedness and perceived isolation.
Several experiments indicate that fasting in animals substantially increased their production of GIT melatonin.
Several explanations for this paradoxical finding have been put forward , but the mechanisms underlying the association between age and negative affect remain largely unclear.
Several explanations including instruments used to characterize participants and variability among study populations contributed to the findings.
Several factors are associated with severe acute pain after surgery , including psychological factors and severe preoperative pain.
Several factors can account for the unfavorable outcome of the elderly , comprising increased glucose values.
Several factors can force retirees to go to paid work.
Several factors increased poor nutrition independently including self-rated health , comorbidity , chronic obstructive pulmonary disease , gastrointestinal disease and cognitive impairment.
Several factors may affect this phenomenon : some of these depend on the patient and others may depend on implant design and materials.
Several factors should be taken into account in geriatric prosthodontic care , including quality of life and psychosocial needs.
Several gaps in our knowledge , however , need to be filled before they can be adopted clinically.
Several genes and risk factors are associated with Parkinson's disease ( PD ) .
Several genes related to cell cycle , cell replication and stemness were found to be changed with the overexpression of Bmi1.
Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without apparent hematological malignancies.
Several genetic defects have been found in patients and families with the clinical manifestations of ARCL II.
Several growth factors and cytokines may be involved in the adaptive responses.
Several high-energy compounds ( HECs ) such as ATP , phosphoenolpyruvate , phosphocreatine and acetyl coenzyme A have been shown to exhibit neuroprotective effects.
Several hypotheses have been proposed on how the transcribed repeat RNA leads to the development of amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Several impairments and comorbidities related to or associated with diabetes are potential disabling conditions that could account for the excess risk of disability.
Several important points deserve mention.
Several indicators are available to measure the frequency of cancers , the main being incidence and mortality indicators.
Several interactions helped to integrate these associations.
Several investigations have also suggested an association between high AOPP levels and aging-related diseases.
Several investigations have demonstrated that running performance gradually decreases with age by using runners > 25 years grouped in 5-year age brackets.
Several investigators have found protection by physiological concentrations of 17β-estradiol against oxidative stress induced by H2O2 in cultured lens epithelial cells.
Several isoforms of apolipoprotein J / clusterin ( CLU ) are encoded from a single gene located on chromosome @number@ in humans.
Several key concepts emerged : @number@
Several key proteins govern the autophagy pathway including beclin1 and microtubule associated protein @number@ light chain @number@ ( LC3 ) .
Several laboratories have described the existence of undifferentiated precursor cells that may act like stem cells in the ependyma of the rodent spinal cord.
Several large cohort studies have disclosed the trajectories of sex steroids changes overtime in men and their clinical significance.
Several large trials indicate that doses in the range of 700-1 , 000 IU / day can lower fracture risk by ~20 %.
Several laser-based ablative resurfacing and nonablative rejuvenation technologies offer non-surgical options for improving the appearance of the skin.
Several leucine > proline substitutions in other PSEN1 transmembrane helices revealed aggressive AD phenotypes.
Several limitations were identified , mainly focused on the lack of a common and standardized method to evaluate the balance during the dual-task performance.
Several lines of evidence indicate that mutant forms of A-type lamins impact on genome function and integrity.
Several lines of evidence indicate that the retina is particularly vulnerable when hypoxia coincides with hyperglycemia.
Several lines of evidence now indicate that TERRA molecules play crucial roles in telomere homeostasis and telomere functions.
Several lines of evidence suggest that alleles influencing breast cancer risk might also be associated with breast cancer survival.
Several lines of evidence suggest that an interaction between MS and SVD may influence MS-related neurodegeneration.
Several lines of evidence suggest that an interplay between a microbial infection and a genetic predisposition could take place in the development of the disease.
Several lines of evidence suggest that insulin signalling dysfunction produces these metabolic alterations and underlie the development of these neurodegenerative diseases.
Several lines of inquiry point to overlapping molecular mechanisms between late-onset Alzheimer disease ( AD ) and age-related macular degeneration ( AMD ) .
Several lines of pathological and physiological evidence reveal that impaired mitochondrial function and dynamics play crucial roles in aging and pathogenesis of neurodegenerative diseases.
Several logistic regression models are estimated using robust standard error estimation to address data clustering at the person level.
Several major sodium transporters or channel subunits were differentially expressed between the genotypes.
Several markers can be used to identify senescent cells , of which the most widely used is the senescence-associated β-galactosidase ( SABG ) activity.
Several markers can be used to identify senescent cells , of which the most widely used is the senescence-associated β-galactosidase ( SABG ) activity.
Several markers have been associated with sarcopenia in the elderly , including bioelectrical indices.
Several measures of physical capacity , including grip strength and lower-extremity physical performance , were associated with pain and multisite pain.
Several mechanisms are known that might counteract this decline in cognitive functions.
Several mechanisms associated with aging are present in the lungs of patients with COPD.
Several mechanisms contribute to the decline of all physiologic functions during aging.
Several mechanisms could help to explain this proposed link ; however , our focus is on insulin resistance and deficiency.
Several mechanisms explain these deleterious effects of HAART on mitochondria , and evidence points to other mechanisms beyond the \ "Pol- γ hypothesis. \ "
Several mechanisms involving abortive apoptosis , telomere erosion , mitotic errors , micronuclei formation , and p53 inactivation might cause chromothripsis.
Several mediator antagonists or inhibitors tested in COPD have so far been disappointing.
Several medical need variables are significantly associated with increased risk for low and high anticholinergic burden.
Several methodological approaches have been developed to objectively classify gait patterns in patients with central nervous system lesions.
Several methods are available for the estimation of muscle or lean body mass.
Several methods of estimating prevalence of dementia are presented in this article.
Several methods to measure biological aging show promise but it is not known if these methods are sensitive to changes caused by geroprotective therapy.
Several microRNA profiling studies have identified changes in microRNA patterns that take place during ovarian cancer development.
Several minerals , namely magnesium , selenium , and zinc , appear to be important determinants of IGF-1 bioactivity.
Several miRNAs , which can function either as oncomiRs or tumor suppressive miRs are deregulated in cancer cells.
Several mis-sense mutations of the POMK catalytic domain are known to cause a severe congenital muscular dystrophy , Walker-Warburg syndrome.
Several modalities have been used to overcome the PIH.
Several model organisms have been used to identify the pharmacological properties of the different plants or active components therein and Drosophila is one of them.
Several models have been proposed in the literature , which should be seen as complementary , instead of contradictory.
Several models of ANOVA , correlation and linear regression were employed.
Several modifiable and non modifiable risk factors have been studied.
Several mouse models with aberrantly increased p53 activity display signs of premature aging.
Several multicomponent instruments predicted mortality , functional status , or MACCEs , but the quality of evidence was low to moderate.
Several nanotechnological approaches were developed to improve life quality for patients with insulin-dependent diabetes.
Several natural and synthetic retinoids are in clinical use or undergoing trials for treating specific diseases including cancer.
Several natural compounds with UV absorption property have been used to substitute for or to reduce the quantity of synthetic sunscreen agents.
Several new biomarkers are emerging and a more biological characterization of underlying pathophysiologic spectra may become possible.
Several new insulin and insulin analogue preparations are now available for clinical use.
Several new radiotracers have been developed that bind to fibrillar Abeta providing sensitive estimates of amyloid deposition in various brain regions.
Several next-generation BTK inhibitors are under development with the goal of decreasing treatment-related toxicity and resistance.
Several nonpharmacological and pharmacological treatment approaches are presented in this article.
Several non-pharmacological interventions have been evaluated to treat BPSD in people with dementia.
Several numbered circles were shown on a monitor and subjects were required to memorize the location of these circles sequentially.
Several nutritional and physiological factors have been linked to depression in adults , including low folate and vitamin B-12 and elevated tHcy levels.
Several observational studies , on the other hand , found negative associations between high testosterone levels and worse cognitive function in older women.
Several observations indicate that numerous E3 Ub ligases intimately collaborate with molecular chaperones to maintain the cellular proteome.
Several of her immediate family members also presented with parkinsonism , cognitive decline , and psychosis.
Several of newer AEDs have good safety and cognitive effect profiles and have no interactions with other drugs.
Several of our DMRs are at genes with potential relevance for age-related disease.
Several of Sirt1's substrates regulate key metabolic processes , and Sirt1 activation may underlie the lifespan prolonging effect of caloric restriction.
Several of these aspects are summarized in this review based on the literature and the results of our studies.
Several of these changes are gender specific affecting postmenopausal women.
Several of these changes may represent a field defect that predisposes to cancer development.
Several of these have been linked to various aspects of AD , and each offers a novel potential therapeutic target for AD.
Several of these modalities have been attempted in human trials , with early outcomes having promising results.
Several of these peptides are in clinical trials for stroke.
Several of the top gene ontology terms identified in downregulated isoforms in old tendon related to collagen and post-translational modification of collagen.
Several operational definitions of frailty and the associated clinical signs , symptoms , and outcomes are outlined.
Several ophthalmological diseases contain aspects of maladjusted inflammatory processes.
Several options are mentioned.
Several organizations have recommended screening older patients to identify those with a high risk of falling and , or fractures.
Several other caspases have demonstrated anti-tumor roles.
Several other compounds including PFOA , PFHxS , and PFuNDA also showed a population-level decrease.
Several other demographic characteristics and other factors were associated with the food-addiction measure in both cohorts of women.
Several other factors appeared to operate differently for women and men.
Several other miRNA-target relationships correlated negatively , indicating possible miRNA regulation , including miR-29a-3p and lipoprotein lipase mRNA levels.
Several other neurodegenerative disorders also produce Parkinson syndrome.
Several other studies also demonstrated that these polymorphisms have no , small , or inconsistent effects on memory function.
Several pairs of sense / antisense promoters were newly identified within single RefSeq gene regions.
Several papers converge to suggest that DNA methylation , histone modification , and small non-coding RNAs are the widely appreciated epigenetic changes towards hTERT modulation.
Several parameterizations of CSF Aβ were compared using likelihood ratio tests and the Akaike information criterion.
Several pathological studies with autopsy samples have demonstrated , however , that dementia subjects with diabetes have less AD-related neuropathology than subjects without diabetes.
Several pathways contribute to the regulation of PEPCK , including the nuclear receptor Rev-erbα and the histone deacetylase SIRT1.
Several patients with Coats plus display critically shortened telomeres , suggesting that telomere dysfunction plays an important role in disease pathogenesis.
Several phosphatidylcholines and some acylcarnitines also differed.
Several plant constituents showed considerable inhibition of IL-6 production , a representative SASP marker.
Several plant extracts , including certain polyphenols , prime innate lymphocytes and enhance responses to secondary stimuli.
Several policy implications are explored.
Several possible explanations for the outcomes are proposed.
Several potential explanations are possible including poor risk standardization , more research is needed.
Several potentially modifiable risk factors were associated with long-term higher levels of inflammatory markers.
Several potential mechanisms have been proposed and warrant further investigation.
Several predisposing , enabling and need factors were associated with the use of potentially inappropriate anticholinergic medications.
Several projects on occupational and environmental risks already applied to a public call for nested research projects.
Several prosthetic treatment needs for residents living with or without dementia were identified.
Several PTM target residues and their corresponding modifying enzymes have been discovered in human and nonhuman desmin.
Several public-funded agencies have identified the synergistic role of systems biology in aging research.
Several published studies suggest that physical activity is a beneficial nonpharmacological intervention to reduce chronic inflammation.
Several questions were addressed.
Several recent clinical studies evaluated the effect daily treatment by IPDE @number@ on the LUTS secondary to BPH among patients with or without ED.
Several recent gene expression studies identified hundreds of genes that are correlated with age in brain and other tissues in human.
Several recent lines of evidence are proving an important role for dopamine in the aging process and in the determination of life span.
Several recent proteome studies with clinically sound designs are available.
Several recent reports have also indicated that TRT may produce cardiovascular ( CV ) risks , while others report no risk or even benefit.
Several recent reviews have highlighted the importance of these cells as a model to understand stem cell biology.
Several recent studies have documented age-related changes in brain activity less amygdala activity and higher prefrontal activity in response to emotional stimuli.
Several recent studies have shown that low serum vitamin D concentration is associated with lower physical function and falls in older adults.
Several recent studies have shown that memory retrieval can be facilitated by reactivating memories during their consolidation during sleep.
Several recent studies suggest that systemic aging in metazoans is differentially affected by functional decline in specific tissues , such as skeletal muscle.
Several regions were characterized only by decreased binding of [ ( @number@ ) C ] ABP688.
Several regression analyses evaluated how years of musical activity , age of acquisition , type of musical training , and other variables predicted cognitive performance.
Several regression strategies were applied to evaluate the association of IgG glycosylation with age , sex , and longevity.
Several reports have highlighted the roles of specific immune subsets in contributing to the immune pathogenesis of these viruses.
Several risk factors , such as childbirth and aging , have been identified.
Several screening instruments are available to document objective impairments and guide further evaluation.
Several sets of explicit criteria for potentially inappropriate medications ( PIMs ) have been developed by expert consensus.
Several sex hormone levels correlated with the two questionnaires , but neither of these questionnaires had sufficient sensitivity and specificity.
Several signaling cascades activate or suppress autophagy in response to diverse environmental cues.
Several signaling pathways , especially nuclear factor κB mediated signaling , play crucial roles in these pathophysiological processes.
Several signaling pathways involved in skeletal muscle apoptosis are currently under intense investigation , particularly the caspase-independent pathway.
Several significant pathways relate to metabolizing sugars and fatty acids ; others relate to insulin signaling.
Several sleep parameters were derived from the accelerometer.
Several SNPs were associated with changes in gene expression levels , and the related genes are connected to biological pathways linking DHEAS with ageing.
Several sociodemographic factors that could plausibly explain age-differences in mixed emotions ( e.g. , retirement , disability ) did not alter the age-effects.
Several speculative associations were , however , identified at loci that have been previously implicated in ALS.
Several steps in the pathway are amenable to reversal for exit from the vicious cycle of EORS.
Several strategies have evolved to prevent and limit mitochondria damage , and macroautophagy plays a role in degrading superfluous or severely damaged mitochondria.
Several studies already reported significant sex differences in dopamine metabolism and its related biological pathways.
Several studies also point towards a general tumor suppressive role for Sirt1 , at least in the context of certain human cancers.
Several studies concerning skin aging have analyzed the changes in gene expression , and very few investigations have been performed at the protein level.
Several studies demonstrated pronounced performance decrements ( dual-task costs ) in older adults for combinations of cognitive and motor tasks.
Several studies demonstrate superiority of some immunosuppressive regimens over others in the QOL domain.
Several studies had demonstrated that PCI does not reduce the risk of death or myocardial infarction when performed to patients with stable angina.
Several studies have also shown that diabetes induces Ca ( 2 + ) dysregulation in neurons.
Several studies have analyzed modulation of gene expression during physiological ageing with interesting , but often contradictory results , depending on the model used.
Several studies have analyzed the movements produced by artificially generated slip and fall stimuli , but few have investigated these stimuli.
Several studies have been conducted in order to assess the diagnostic accuracy of various nuclear medicine techniques in diagnosis of PVE.
Several studies have demonstrated decreases of docosahexaenoic acid-containing phosphatidylcholines ( DHA-PCs ) in the AD brain.
Several studies have demonstrated hereditary and genetic influences on thyroid function.
Several studies have demonstrated that PPARγ activation is involved in the immunostimulation of amyloid-β precursor protein processing by nonsteroidal anti-inflammatory drugs ( NSAIDs ) .
Several studies have established a number of post-transcriptional regulators implicated in metabolic diseases such as diabetes and obesity.
Several studies have evidenced that in aging , osteoblast functional activity is impaired : osteoblast proliferation is slower and matrix deposition is less efficient.
Several studies have found that aerobic exercise enhances cognition and likely prevents cognitive decline in the elderly.
Several studies have identified changes in certain gait parameters as independent predictors of fall risk.
Several studies have identified violence and trauma resulting from hospitalization as significant problems with current acute PGU care.
Several studies have investigated age-related effects , but compared young versus old subjects.
Several studies have investigated the agreement between these two devices , but not in populations with elevated levels of arterial stiffness.
Several studies have investigated the pathophysiology of MetS and cardiovascular complications in HIV infection.
Several studies have proposed the dentate and CA3 subfields of the hippocampus as the potential locus of this change.
Several studies have related oxidative stress , production of free radicals , and neuroendocrine and genetic changes to the physiopathogenesis of vascular aging.
Several studies have reported a direct correlation between birth weight and nephron number and an indirect association between nephron number and blood pressure.
Several studies have reported that oxidative stress and failure of the antioxidant system are the major factors contributing to lens oxidation.
Several studies have shown a direct involvement of hTERT in gene transcription.
Several studies have shown a strong relationship of IBS with psychiatric conditions.
Several studies have shown increased frequency and number of Tregs in the elderly.
Several studies have shown loss of glomeruli due to age-related glomerulosclerosis.
Several studies have shown that acute stress affects working memory ( WM ) in young adults , but the effect in older people is understudied.
Several studies have shown that conflict processing improves from childhood to adulthood and declines from adulthood to old age.
Several studies have shown that obesity is associated with changes in human brain function and structure.
Several studies have shown that the proportion of free iron increases with age , leading to increased Fenton chemistry in later life.
Several studies have shown that total nephron ( glomerular ) number varies widely in normal human kidneys.
Several studies have suggested an association between obesity , alterations in glucose metabolism , diabetes and the BRS-3 receptor.
Several studies have suggested an association between the age of menopause and longevity.
Several studies have suggested a relationship between vascular calcification , which is a predictor of cardiovascular morbidity and mortality , impaired bone metabolism and fractures.
Several studies have suggested that income , wealth , and perceptions of economic status are associated with increased risk of death among elderly people.
Several studies have suggested that other vasoactive hormones , including endothelin and apelin systems are also associated with development of AS.
Several studies have suggested that repletion of testosterone in deficient men with these comorbidities may indeed reverse or delay their progression.
Several studies , including SYST-EUR2 , NORDIL , and STOP-2 , have demonstrated the effectiveness of these drugs in the geriatric patient.
Several studies indicate that SIRT2 is upregulated under serum deprivation conditions.
Several studies on molecular mechanisms underlying death of erythrocytes have been reported.
Several studies reported coagulation factor X deficiency and excessive fibrinolysis in immunoglobulin light chain amyloidosis.
Several studies reported the antioxidant activity of bifidobacteria using assays in vitro.
Several studies showed that Beclin-1 expression is associated with several prognostic factors of gastric carcinomas.
Several studies show that hypertension-driven brain damage and pathogenic mechanisms lead to an Aβ increase.
Several studies suggest an increased risk of stroke following zoster infection , but the results are conflicting.
Several studies suggest poorer self-reported health among foreign-born compared to natives , while results on mortality and life expectancy are inconclusive.
Several studies suggest telomere length may be positively correlated with cognitive performance but the evidence is equivocal.
Several studies suggest that the clinical features of EOS differ from those of sarcoidosis in younger patients.
Several studies support the relation between leptin and Alzheimer's disease ( AD ) .
Several studies with similar outcomes are needed to establish causality.
Several subcortical structures have been also involved in the etiology of FOG , principally the caudate nucleus and the locomotor centers in the brainstem.
Several subgroup analyses were performed , defined by anti-dementia medication use , baseline MMSE score , and DLB core features.
Several such compounds , including rapamycin , metformin and resveratrol , have been identified as potential DR mimetics.
Several symptom questionnaires have been proposed for detecting TD.
Several systemic factors were significantly correlation with the change in IOP.
Several target proteins of the sirtuin genes are key sensors and / or effectors of oxidative stress pathways including FOXO3 , SOD3 , and AKT1.
Several technologies entered our homes to change our lives.
Several template update strategies are also studied as possible measures to reduce the impact of aging on the system's performance.
Several terms are used for this syndrome , but late-onset hypogonadism ( LOH ) is preferred.
Several testosterone-replacement therapies are approved for treatment and should be selected according to the patient's preference , cost , availability , and formulation-specific properties.
Several theoretical models have been proposed to explain the putative underlying relationship between brain function and performance.
Several theories have been proposed to explain age-related declines in immune responses.
Several theories link processes of development and aging in humans.
Several theories of aging are reviewed along with the potential impact of telomerase in developing new treatments.
Several therapeutic approaches have been developed to preserve retinal function or restore eyesight in pathological conditions.
Several tools are available for geriatric assessment ( GA ) and there is strong evidence that an effective GA can detect previously unknown problems.
Several transcatheter mitral repair technologies have been developed during the last decade.
Several transgenic mouse models expressing tau mutations have been tested extensively for memory or motor impairments , though reports of amygdala-dependent behaviors are lacking.
Several treatment options exist for these patients , ranging from immobilization with a semirigid orthosis to surgical arthrodesis.
Several treatments have been effective in the prevention and management of osteoporosis.
Several trials have shown the benefits of treating hypertension in elderly patients.
Several unique nonsynonymous variants were identified in the extremes of AEE with some occurring at highly conserved sites predicted to affect protein structure and function.
Several vaccine-preventable diseases-influenza , pneumonia , herpes zoster , and pertussis-threaten the health of older adults in the United States.
Several variants Currently , the rate of aging is increasing rapidly and the number of elderly patients in hospitals is rising in Japan.
Several well-performing clustering algorithms exist to infer topological network partitions.
Several WM multi-subject clustering methods have been proposed to study WM bundles.
Severe adverse reactions were found to a lesser extent in patients treated with HA and PLA.
Severe and nonsevere dementia were associated with decreased odds of low burden but increased odds of high burden.
Severe aortic stenosis is a significant source of morbidity and mortality among the aging population.
Severe AP was classified among @number@ patients ( @percent@ ) .
Severe arthrosis was more prevalent at earlier ages among women and reached @percent@ in women and @percent@ in men who were @number@ years or older.
Severe cardiac sympathetic degeneration occurs in DLB , but not in AD , offering a potential system for a biological diagnostic marker.
Severe cognitive effects were at least @number@ times as important as severe constipation.
Severe complications were not observed in this series.
Severe COPD and ageing are independent and probably concurrent conditions leading to malnutrition.
Severe COPD mainly affected right ventricular function.
Severe CTS progressively increased , reaching more than @percent@ of the CTS diagnoses in people over @number@ years.
Severe family dysfunction was associated with increased risk of cognitive impairment.
Severe frailty on admission , as determined by the FI-lab ( FI-lab > @number@ ) , was not associated with adverse outcomes.
Severe hypoglycemia was more prevalent in patients with dementia ( @percent@ ) compared with patients without dementia ( @percent@ ) .
Severe impairment in the overall field or a region was defined as average sensitivity in the lowest quartile of sensitivity.
Severe injection site responses were reported less frequently with VYC-15L than NASHA.
Severe intracranial hemorrhage is a known side effect of alteplase but is not associated with age in patients with acute ischemic stroke.
Severe leptin resistance in Nur77 KO mice with increased appetite , lower energy expenditure , and hyperleptinemia contributes to aging-induced obesity.
Severely affected patients had worse impairment in all Work Productivity and Activity Impairment Questionnaire domains.
Severely injured older adults have far worse outcomes than younger adults.
Severe memory loss , confusion , and impaired cognitive abilities characterize AD.
Severe mental illness ( SMI ) impacts many different facets of individuals ' lives.
Severe MR and AS prevalence rates increased strikingly with age.
Severe obesity is more prevalent in women than men worldwide , and obesity pathophysiology and the resultant obesity-related disease risks differ in women and men.
Severe olfactory dysfunction , however , is not a fully penetrant trait at the time of symptom onset.
Severe or sustained oxidative stress impairs the function of the UPP and decreases intracellular proteolysis.
Severe pain was associated with greater AL defined by all four formulations.
Severe renal abnormality occurred in @percent@.
Severe scattering of the data leads to an estimation error that is too great for this method to be of practical relevance in aad estimates.
Severe small-vessel disease , severe amyloid angiopathy , and hippocampal sclerosis were also independently associated with the degree of cognitive impairment.
Severe vertebral fractures also were associated with poor trabecular microarchitecture regardless of aBMD.
Severe vitamin D deficiency was also independently associated with the development of MCI when analyzing @number@ subjects whose baseline MMSE scores were < 27.
Severe white matter hyperintensities ( WMH ) represent cerebral small vessel disease and predict functional decline in the elderly.
Severity and duration of visual impairment had no effect on loneliness.
Severity of ASC correlated with higher rates of discharge to rehabilitation / nursing facilities compared with home discharge.
Severity of dementia , male sex , and frontotemporal dementia were associated with greater levels of neuropsychiatric symptoms at baseline.
Severity of depression was assessed with the Inventory of Depressive Symptomatology ( IDS ) at 6-month intervals.
Severity was similar to that for object recognition and visuospatial processing.
Sevoflurane , an inhaled anesthetic , sequesters acrolein and enhances the formation of a serotonin-derived melanoid ( SDM ) .
Sex , age , and axial length ( AL ) are the factors that influenced macular thicknesses.
Sex , age , and sex hormone levels may affect frequency and extension of forgetting.
Sex and age effects were observed within the buccal samples as is the norm within blood-derived DNA.
Sex and age have important influences on sympathetic neural control of blood pressure in humans.
Sex and age-specific upper reference limits for cTnI should be considered.
Sex- and age-specific variances in the prevalence of hypertension are partly induced by estrogen.
Sex and behavior also played a large role.
Sex and CMV independently impacted on multiple B-cell and T-cell subsets.
Sex and COL5A1 genotype accounted for @percent@ of the variance in SR ROM in the older group.
Sex and education did not modify the degree of deterioration with age.
Sex and hemisphere had no influence on network pattern.
Sex and race had only a small effect on the appropriate age to stop screening.
Sex and the degree of pain were not correlated with the thickness of the LF.
Sex and the degree of pain were not correlated with the thickness of the LF.
Sex-based differences in balance problems were determined.
Sex-based memory advantage does not mitigate age-related memory decline in either APOE ɛ4 carriers or non-carriers.
Sex-dependent differences were analyzed.
Sex did not influence E / A ratio ( p = @number@ ) but age decreased it significantly ( p < @number@ ) .
Sex did not influence such differences.
Sex did not modify the association of season with sclerostin , so the men and women were analyzed together.
Sex did not show a significant effect.
Sex difference in performance remained unchanged across years.
Sex differences and health factors may modify the associative deficit regardless of age.
Sex differences and the differences in the method of categorizing depressive symptoms may contribute to the inconsistencies.
Sex differences in AF epidemiology are insufficiently understood.
Sex differences in FMD and baseline artery diameter were assessed using mixed linear models.
Sex differences in human lifespans imply nonautonomous effects modulated by sex-specific gene-environment interactions that could still include pheromonal mechanisms.
Sex differences in lifespan exist world-wide , with women outliving men by more than a decade in some countries.
Sex-differences in PF did not reach significance.
Sex differences in predictors of increased VA among cardiovascular ( CV ) risk factors and arterial stiffness ( AS ) parameters were identifi ed.
Sex differences in predictors of increased VA were identifi ed.
Sex differences in systolic and diastolic blood pressure levels and trends with age have been consistently observed in both industrialized and unindustrialized populations.
Sex differences in the timing of dementia risk factors have important implications for brain health and hypertension management.
Sex differences in white matter microstructure were examined in relation to pubertal development.
Sex differences ( p = 0.002 ) regarding MVC were attributed to the greater ( p < 0.01 ) peripheral fatigue of males vs females.
Sex differences start to develop at puberty and are maintained during aging.
Sex differences warrant further investigation and suggest a need for targeted interventions.
Sex differences were evident in adult hyoid bones and discriminant function analysis correctly confirmed sex in @percent@ of cases.
Sex differences were evident , specifically in gFD and sFD , with men showing higher FDs.
Sex differences were noted such that men demonstrated greater lip and cheek strength but not tongue strength.
Sex effects on links between callosal thickness and intelligence during childhood and adolescence are present but appear rather weak in general.
Sex had a major impact on absolute counts of CD4 + T cells which were higher in females.
Sex had a stronger effect on pulse pressure than acculturation.
Sex-hormone binding globulin ( SHBG ) was not correlated with any measure of FT.
Sex hormones and aging have been also suggested to drive the incidence of ocular surface diseases such as dry eye and cataract.
Sex hormones and metabolic parameters were measured.
Sex hormones are important determinants of body composition.
Sex hormones , genes encoded on the sex chromosomes , and gender-specific behaviors likely contribute to these differences.
Sex hormones thus seemingly boost DNA methylation at the RELN promoter.
Sex modified the association between adiponectin and fracture ( p = @number@ for interaction ) .
Sex of individuals was assessed for its influence in aging.
Sex of participants and exercise type are two possible factors contributing to this variation.
Sex-related differences in the developmental trajectory of functional homotopy were detected within dorsolateral prefrontal cortex ( Brodmann areas @number@ and @number@ ) and amygdala.
Sex-related differences were observed at ages below @number@ years.
Sex significantly moderated the relation between testosterone reactivity and buccal TL.
Sex-specific analyses revealed that these relationships were significant in men only.
Sex-specific BMI latent class trajectories were derived from @number@ possible measures of height and weight from @number@ to @number@
Sex-specific change in the mean HAS was computed for the age categories of 65-69 , 70-74 , 75-79 , 80-84 , and ≥85 years.
Sex-specific data can improve disease prevention , diagnosis , and treatment as well as reduce inequities.
Sex-specific differences also were present in the percentage of NK cells but not in their cytotoxic activity and in circulating cytokine levels in plasma.
Sex-specific odds ratios ( OR ) and @percent@ confidence intervals ( CI ) were calculated from sequential logistic regression models.
Sex-specific proportional hazard models were used to assess the effect of leptin on all-cause and CV mortality.
Sex-standardized cumulative incidence also remained steady.
Sex steroid hormone levels and lipid profiles were determined.
Sex steroid hormones exert effects in nonreproductive organs , such as the lungs.
Sex steroid hormones may also drive sex differences in AD through their organizational effects during developmental sexual differentiation of the brain.
Sex steroids are central to sexual development and reproduction , exerting pleiotropic effects on multiple tissues and organs throughout the lifespan of humans.
Sex steroids are fundamental to skeletal development , bone homeostasis and immune function.
Sex steroids in numerous ways can modify cerebral physiology , and along with many processes adult neurogenesis is also modulated by sex steroids.
Sex steroids , primarily estrogen and testosterone , have been shown to play a central role in the aging process of bone.
Sex-stratified analyses were conducted using adjusted stepwise regression models.
Sex-stratified linear mixed-effects modeling was used to investigate whether drinker types differed in their relationship to pulse wave velocity and its progression over time.
Sex-stratified linear regression analyses were used with adjustments for gestational age , smoking , and education.
Sexual Activity and Physical Tenderness in Older Adults : Cross-Sectional Prevalence and Associated Characteristics.
Sexual aging should be part of health care and medical education.
Sexual arousal disorder , though commonly affected by the same factors as HSDD , is heavily associated with psychotropic drugs and mood elevators.
Sexual behavior clearly follows the established principles and phases for wanting , liking and satiety involved in the pleasure cycle of other rewards.
Sexual behavior is critical to species survival , yet comparatively little is known about the neural mechanisms in the human brain.
Sexual decline in old age was considered redeemable with the support of biomedical and traditional medicines.
Sexual desire , erectile function , overall sexual function scores , partner intimacy , and health-related quality of life did not differ significantly between groups.
Sexual desire was decreased or absent in @percent@ of the postmenopausal respondents.
Sexual differences in reaction of monocytes to pneumonia are not present.
Sexual dimorphism was only observed at T IV-V.
Sexual dysfunction and in particular erectile dysfunction ( ED ) are frequent complications of DM.
Sexual dysfunction in women is a common and often distressing problem that has a negative impact on quality of life and medication compliance.
Sexual dysfunction is common in ageing men and may be exacerbated by the special medical issues and psychological problems associated with haemophilia.
Sexual dysfunction ( SD ) is devastating to a man's ego and its presence could defeat his purpose of masculinity.
Sexual function , quality of life , and body composition were also assessed.
Sexual functions ( erectile function , sexual activity , and sexual desire ) were self-reported via standardized questions.
Sexual health across the life course is influenced by biological and psychosocial factors.
Sexual health is a key public health issue.
Sexual health severely decreases with age.
Sexual identity and gender were weak covariates of service utilization.
Sexual interest and capacity can extend far into later life and result in many positive health outcomes.
Sexuality and sexual needs in older adults remains a neglected area of clinical intervention , particularly so in long-term care settings.
Sexuality is an important aspect of active aging.
Sexuality is an important , yet often overlooked , aspect of successful aging.
Sexuality plays an important role in elders ' lives.
Sexually active men had better mobility ( p = @number@ ) and erectile function ( p < @number@ ) .
Sexually active men reported higher levels of concern with their sexual health and sexual dissatisfaction than women at all ages.
Sexually active women had better sexual desire scores ( p < @number@ ) and more drank alcohol ( p = @number@ ) .
Sexual minorities ( SMs ) were more likely to have non-kin-based social networks and reported higher levels of loneliness compared with heterosexuals.
Sexual orientation and gender identity are not commonly addressed in health and human service delivery , or in educational degree programs.
Sexual problems and concerns were prevalent , including patient and / or partner fear of \ "causing another heart attack. \ "
Sexual problems as low desire and difficult erections are frequently reported by TD patients.
Sexual , psychological and physical symptoms were evaluated using the Androgen deficiency in Aging Male ( ADAM ) questionnaire.
Sexual transmission was the main route , accounting for @percent@ of infections in this group.
Sex was a significant effect modifier of this relationship , whereby the increase in HDL-C with age was steeper for women than for men.
Sex was not associated with primary outcome rate ( @number@ @percent@ CI , @number@.93-1.10 ) , nor did it significantly modify the age effect.
SF-12 derived Physical Component Summary ( PCS ) and Mental Component Summary ( MCS ) scores varied little by age and country.
SF-12 MCS scores also improved to a greater extent in frail compared to non-frail participants ( @number@ vs < @number@ point ) .
SF-36 physical and mental components were significantly increased in the intervention group.
SF-36 scores were between @number@ and @number@ points higher among more physically active compared to less active patients.
SF-36 scores were worse in those with low visual acuity , while VFQ-25 domain scores were poorer in those with vision impairment / blindness.
SFBIA tends to significantly overestimate muscle CSA in subjects who had relative expansion of ECW in the thigh segment ( P < @number@ ) .
SFN-induced proteasome activity was significantly enhanced in Hsp27-overexpressing cells but absent in Hsp27-silenced cells.
SF proteins associated with chelation and anti-aging physiological functions such as matrilin , transthyretin , and complement @number@ increased at least 2-fold in concentrations.
SFRP1 methylation in whole blood may be associated with gastric cancer risk.
SG-ADVISER web server is freely available to all users at @url@ .
SGK-1 has been also associated with cancer , neurodegenerative diseases , and cardiovascular disease , among other age-related diseases.
Shame decreased from adolescence into middle adulthood , reaching a nadir around age @number@ years , and then increased in old age.
Shape from shading may thus provide a simple behavioral tool to track age related changes in hemispheric organization.
Shared decision-making between patients and physicians is now the ' gold standard ' in Western Europe and the United States.
Shared frailty models were computed to further explore the association between CRC specific survival and insurance status after adjustment for demographic and treatment variables.
Shared genetic pathways are a major focus , particularly those favoring apoptosis and cell proliferation at opposite ends of the spectrum.
Sharing a home with a partner can mitigate these adverse effects , while other combinations of relationship status and living arrangement do not.
Sharing an intense transgenomic metabolism with the host , the intestinal microbiota is an essential factor for several aspects of the human physiology.
Sharp estimates for many predictors of higher levels of life quality are also found.
Shaving presents an opportunity to deliver cosmeceuticals for men.
SHBG was positively correlated and TT and AR% were negatively correlated with the course of DM.
She also discusses related issues-the importance of being culturally competent about U.S. culture.
Shear bond atrength ( SBS ) was tested on the etched enamel of extracted human teeth.
Shear bond strength and adhesive remnant index were also tested.
Shear forces predominantly exhibited cohesive failure ( @percent@ ) , whereas peel forces predominantly exhibited adhesive failure ( @percent@ ) .
Shear force was applied to the adhesive interface in a universal testing machine ( @number@ mm / min ) .
( Shear , K. , Frank , E. , Houck , P. R. , & Reynolds , C. F. 3rd.
Shear tests were executed using @number@.4-mm-thick wire at @number@ mm / min.
Shear wave elastography can be used to quantify the shear modulus ( i.e. an index of stiffness ) of a specific muscle.
Shear wave velocity and elastic modulus were measured at the proximal , middle and distal areas of the patellar tendon.
She became more reactive , with a shriller voice.
She decided to seek medical help.
She developed nausea and psychiatric symptoms , followed by fever and an acute progressive disturbance of consciousness.
She died of respiratory arrest within 24h after PRES diagnosis.
She explains how international certified nursing assistants can benefit residents because of skills developed by family-centered care in their countries of origin.
She got the injection for correction of HA filler excess.
She had hyperreninemia and hyperaldosteronemia without kidney failure or renal arterial stenosis.
She had hypokalemic metabolic alkalosis , elevated plasma cortisol and ACTH , and elevated urinary cortisol.
She had received an operation and adjuvant radiotherapy @number@ years previously.
She has been observed for over @number@ years , as she repeatedly refused reoperation.
She is the founder and Director of the Fremont Community Therapy Project , a low-fee psychotherapy training clinic in Seattle.
She lacked insulin resistance , hypertriglyceridemia , hepatic steatosis , and diabetes.
She lived with a 92-year-old roommate , developed close friendships with many of the residents , and kept a detailed journal of her experience.
Shelterin is the major protein complex bound to mammalian telomeres ; however , its potential relevance for cancer and ageing remained unaddressed to date.
She married late in life and started trying to conceive shortly thereafter.
She points out how religiousness not only affects residents but is a buffer for staff against the stress of physically and emotionally demanding low-wage work.
She suffered from repeated diarrhea and vomiting , and experienced syncope.
She then approached our plastic surgery department for help.
She was able to independently ambulate around her home with her rolling walker.
She was admitted to our hospital and was diagnosed with acute colitis and syncope.
She was noted as having a 1-week history of vision loss in her left eye , along with a 2-month history of a nonspecific headache.
Shh mediates activity-dependent and injury-induced hippocampal neurogenesis.
Shifting visual focus on the basis of the perceived gaze direction of another person is one form of joint attention.
Shift in HDL subfractions might be responsible for the increased risk of atherosclerosis in CKD patients.
Shifts in body weight and composition were associated with favorable changes in clinical parameters of cardiometabolic risk and mobility.
Shifts in splicing patterns occur in the development , tumorigenesis , and response to diverse stimuli in a tissue-specific and cell type-specific manner.
Shift work disorder is associated with insomnia and excessive drowsiness as individuals often work during their sleeping hours.
Shift work , involving repeated and chronic exposure to misaligned environmental and behavioral cycles , disrupts circadian coordination.
Shift work tolerance should be considered in different shift work populations.
Shore A hardness was measured according to the American Society for Testing Materials specification D2240.
Short-acting PRN benzodiazepines were associated with lower night time sleep quality and longer day-time napping compared to long-acting regular benzodiazepines.
Short and long-term outcome measurement is an integral part of the process.
Short-chain fatty acid concentration ( @percent@ ) and bacterial composition ( @percent@ ) were the most frequently studied outcomes.
Shortened telomeres are thought to limit the proliferation of cells and are associated with increased morbidity and mortality.
Shortening of PBMC telomere length correlated with airflow obstruction and diffusing impairment.
Shorter axial length or hyperopia may be associated with higher intraocular concentration of cytokines.
Shorter duration of AMD , as measured by the subjective duration of visual symptoms , is associated with better visual outcome after treatment.
Shorter FBLs were also associated with increased age.
Shorter frontal and temporal FBLs were associated with lower performance on CPS tests TMT-A and CWIT @number@
Shorter frontal , parietal , and occipital FBLs were associated with poorer performance on L-N Seq and Symbol Coding.
Shorter leukocyte telomere length in UHR could represent early signs of accelerated aging in this population.
Shorter LTL was associated with older age , current smoking , and white race / ethnicity.
Shorter LTL was significantly associated with higher c-reactive protein , interleukin-6 , area under the curve with respect to increase , and heart rate.
Shorter occipital FBLs were associated with poorer performance on the EF tests TMT-B and CWIT @number@
Shorter persons had more proximally positioned fixed ROIs which moved distally when corrected , so dimorphisms lessened.
Shorter RTL was associated with older age , and RTL was shorter in males than females.
Shorter RTL was found among the SHS group compared to the ideal health group ( p < @number@ ) .
Shorter survival in the elderly has been associated with deterioration of the immune system and also with functional disability.
Shorter telomere length was observed in duodenal and gastric ulcer patients compared with non-ulcer subjects among NSAID users.
Shorter telomeres appeared frequently in those with cataract , osteoporosis , atherosclerosis , or coronary heart disease.
Shorter telomeres are proposed to restrain adaptive immunity as an energy saving mechanism.
Shorter telomeres have been associated with increased adiposity in adults.
Shorter telomeres have been associated with increased incidence of diseases and poor survival.
Shorter-term effects of TC were assessed by randomly allocating TC-naïve participants to either @number@ months of TC training or to a waitlist control.
Shorter term transition probabilities that underlie multiperiod trajectories are examined.
Shorter TL in SAT is entirely due to shorter TL in the SVF compared to visceral AT ( P < @number@ ) .
Short-Form Six-Dimension ( SF-6D ) health utility index scores were derived from the SF-36.
Short , intraweekly cycles of anti-HIV combinations have provided intermittent , effective therapy ( on @number@ patients ) ( @number@ ) .
Shortly after surgery , a painful lytic image in the external cortex of her right femur diaphysis was detected.
Shortly after surgery @number@ patients ( @percent@ ) developed postoperative cognitive dysfunction , which has recovered at six-months-follow-up.
Shortly afterward , we tested their recognition memory for the words and false memory for non-presented but related words.
Short sleep was reported by @percent@ ( n = @number@ ) and long sleep by @percent@ ( n = @number@ ) of the sample.
Short stature was associated with poorer functional health only among men and the relationship was explained by adult characteristics.
Short telomeres also contribute to genome instability and are a hallmark of many cancers.
Short telomeres are associated with atherosclerosis.
Short telomeres are associated with some diseases , such as dyskeratosis congenita , idiopathic pulmonary fibrosis , and aplastic anemia.
Short telomeres block the proliferative capacity of stem cells , affecting their potential to regenerate tissues , and trigger the development of age-associated diseases.
Short-term adaptations in learning the sinusoidal task were similar for young and older adults.
Short-term challenges include preparing the dwelling for the patient and understanding the organization of care at home.
Short-term change in nerve function was not associated with concurrent short-term change in muscle power / kg.
Short-term disuse and subsequent recovery affect whole muscle and single myofiber contractile function in young and old.
Short-term growth hormone substitution might improve liver repopulation by transplanted hepatocytes , thus augmenting the therapeutic benefit of clinical hepatocyte transplantation in older patients.
Short-term improvements in memory were maintained at @number@ months.
Short-term interruption of antiplatelet or anticoagulant drugs before lung cancer surgery and heparinization was acceptable from the view of perioperative outcomes.
Short-term ( lifting effect ) and long-term ( anti-wrinkle ) improvements of skin roughness parameters were evaluated by both objectives ' and subjectives ' measurements.
Short-term mortality ( < 140 person-months ) was higher in women , whereas long-term mortality ( > 140 person-months ) was higher in men.
Short-term mortality is higher in CHD ( vs. non-CHD ) patients undergoing OHT , regardless of prior cardiac surgery status.
Short-term nitrite therapy reverses age-associated vascular endothelial dysfunction , large elastic artery stiffness , oxidative stress , and inflammation.
Short Term Outcomes were also prospectively assessed.
Short-term randomized controlled trials of muscle protein synthesis have demonstrated that whey protein increases synthesis more so than casein or soy isolates.
Short-term regimens of CR and CRMs alleviated age-related EMT via AMPK-mTOR signaling , suggesting a potential approach to reducing renal fibrosis during aging.
Short-term safety appeared favourable.
Short-term studies in rodent models have demonstrated increased sclerostin in response to mechanical unloading that is reversed with reloading.
Short-term survival was @percent@ and @percent@ at @number@ days and @number@ months , respectively.
Short-time Fourier transform was used to analyze heart rate variability during shifts.
Short TL was independently associated with increased risk of prevalent microalbuminuria in diabetic men with CKD ( p = @number@ ) .
Short TL was significantly associated with CKD progression among smokers ( p = @number@ ) and diabetic patients ( p = @number@ ) .
Short training intervention programs may decrease QoL by changing the elderly's daily routine and making it more active and exhausting.
Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians , with @number@ differently abundant lipid species with respect to elderly subjects.
Shoulder angle at the door could be predicted , for larger aperture ratios , by both shoulder angle variability and lateral trunk variability.
Shoulder arthroplasty has demonstrated encouraging outcomes but the outcome data is not yet as robust as the data for hip and knee arthroplasty.
Shoulder ROM with an angle meter and shoulder pain were evaluated.
Should ongoing and future studies suggest early phenotype-driven therapy improves in-hospital and post-discharge outcomes , ED treatment decisions will need to evolve accordingly.
Should post-transplant diabetes develop , there are a range of treatment options available.
Should such misfolded proteins escape the protein quality control ( PQC ) system , they become proteotoxic and accelerate the loss of cellular integrity.
Should this change how she evaluates her life , and would a similar change occur when she turns @number@ ?
showed an association in our cohort with a false discovery rate of less than @percent@.
SHP-2 ( encoded by PTPN11 ) is a ubiquitously expressed protein tyrosine phosphatase required for signal transduction by multiple different cell surface receptors.
SHP2 is a widely expressed protein tyrosine phosphatase required for signal transduction from multiple cell surface receptors.
Shrinkage-strain-rate data were obtained from numerical differentiation of shrinkage-strain data with respect to time.
SHS-attributable healthcare costs were estimated using a prevalence-based annual cost approach.
Shunt infections occurred in @percent@ of primary implantations.
Shunt revisions continued to occur as late as @number@ years of age.
SHU were more likely to have leg oedema.
Sialidase mimicked this stimulatory action.
Sibling analyses revealed that the genetic risk score was predictive of BMI net of risk factors shared by siblings.
SIBs showed extensive antero-medial temporal lobe activation for faces that was not present in any other group , suggesting a potential compensatory mechanism.
SICI was released in both tDCS conditions for young and old.
Sickle cell disease is one of the most systemic pathologies contrasting with its monogenic characteristic and its inter- and intra-individual variability.
Sickle cell disease ( SCD ) is an inherited haemoglobin disorder , associated with recurrent painful episodes , ongoing haemolytic anaemia and progressive multi-organ damage.
Sickness absence ( SA ) among pregnant women is high.
Sick sinus syndrome remains a highly relevant clinical entity , being responsible for the implantation of the majority of electronic pacemakers worldwide.
Side effects and complications of up-titration were minimal.
Side effects are minimal and short lived.
Side effects following MAL-PDT were evaluated.
Side effects following MAL-PDT with red versus blue light were similar and mild in severity.
Side effects included transient erythema and edema which were mild and self-limited.
Side effects included transient nipple tenderness in @number@ patient.
Side effects of head-mounted visual displays include nausea and disorientation , but , have not been reported specifically in older subjects.
Side effects such as post-inflammatory hyperpigmentation , epidermal burns , and scar formation were not observed.
Side effects that do occur are generally mild and transient in nature.
Side effects were absent.
Side-effects were also evaluated.
Side effects were also recorded after each treatment.
Side effects were classified as minor or major and were analyzed on the basis of their incidences in each age group.
Side effects were mild in nature and did not differ between treatment sides , and all but mild erythema resolved by day @number@
Side-effects were minor and did not preclude patients from continuing the study.
Sidestream darkfield imaging showed a significantly greater thickness of the erythrocyte perfused boundary region in the type @number@ diabetic patients compared with the young.
SIF420 [ kx0.5 , km0.5 ] was higher in girls than boys in patients with diabetes patients.
SIF concentrations in post-menopausal women arise from the increased fluoride release from bone after menopause.
SIF concentrations in women were significantly higher in the post-menopausal group than in the pre-menopausal group.
SIF concentrations were independently related to eGFR in both sexes and to menopause status in women.
SIF concentrations were measured using highly sensitive methods.
SIF measurements were obtained on the underside of the forearm near the elbow using a skin fluorescence spectrometer.
Sigmoidoscopy was the first endoscopic procedure performed in @percent@ of patients and rectal enema was the first method of bowel preparation in @percent@ of them.
signal changes in the amygdala while viewing erotic video were positively correlated with estrogen levels in the two groups.
Signal detection analysis using @number@ variables was applied to identify factors associated with the occurrence of severe pedestrian injuries.
Signaling by target of rapamycin ( mTOR in mammals ) has been shown to modulate lifespan in several model organisms ranging from yeast to mice.
Signaling can be altered at ligand , receptor or signal transduction molecule level through mutagenesis.
Signaling components of the UPR are emerging as potential targets for intervention and treatment of human liver-associated metabolic diseases.
Signaling from the PC recruits the autophagic machinery to trigger autophagosome formation.
Signaling of CD200R1 is hypothesized to attenuate osteoclastogenesis.
Signaling pathway activity was assessed by western blotting.
Signaling pathways and downstream effectors were characterized by Western blotting , immunofluorescence microscopy , luciferase reporter assays , qPCR , and studies.
Signaling pathways implicated in disrupted myelination include those mediated by Notch , WNT-beta catenin , and hyaluronan.
Signaling pathways induced by CR are therefore potentially new therapeutic targets for neurodegenerative diseases.
Signal intensity on the inphase and out-of-phase MRI was analyzed from the same location and size of the single-voxel ( @number@ ) H MRS measurement.
Signal intensity was higher in women than in men in both groups.
Signal intensity was reduced in women , but not in men , in the bipolar group.
Signals are transduced by relatively few reactive oxygen species ( ROS ) , through very specific redox modifications of numerous proteins and enzymes.
Signal transducer and activator of transcription @number@ ( STAT3 ) is a transcription factor that plays a critical role in heart development and protection.
Signal transduction proteins expression ( Akt and ERK ) was measured by Western blot.
Signatures of positive selection were also investigated.
Significant decreases in muscle mass and strength are also common.
SIGNIFICANCE : According to the study results nano-composite CAD / CAM crowns should be cemented with VAR.
SIGNIFICANCE : Aging is a multi-factorial process that may be associated with several functional and structural deficits which can evolve into degenerative diseases.
SIGNIFICANCE : All tested specimens survived artificial aging and exhibited clinically acceptable wear resistance and fracture resistance.
SIGNIFICANCE : An auditory late negative wave could represent a marker of auditory working memory encoding deficits in Alzheimer's disease.
Significance and validities of such ' life codes ' in biology beyond genomic and proteomic concepts has also been clarified.
SIGNIFICANCE : Bleaching gels might alter the physical properties of resin-based composites , especially at low irradiation times and fresh placed restorations.
SIGNIFICANCE : Chronic exposure to environmental ultraviolet radiation ( UVR ) plays a key role in both photocarcinogenesis and induction of accelerated skin aging.
SIGNIFICANCE : Clinically the prevalence of the double peaked P1 may have been underestimated , and its reflectance of demyelinating disease overestimated.
SIGNIFICANCE : Combined assessment with several different evoked responses may be useful to evaluate the disease conditions of patients with retrocochlear lesions.
SIGNIFICANCE : CTS seems to be a chronic condition whose signs and symptoms may vary and progress , becoming worse over time.
SIGNIFICANCE : Epilepsy has major socioeconomic consequences for the individual patient and for society.
SIGNIFICANCE : Epileptic spasms occur more frequently in the waking state and daytime.
SIGNIFICANCE : Even the standard visually assessed EEG can complement a memory clinic diagnostic workup.
SIGNIFICANCE : Fused crowns are superior to luted crowns.
SIGNIFICANCE : Greater muscle activation requirements can have negative implications on fatigue resistance at low to moderate intensities in older individuals.
SIGNIFICANCE : Heart disease is the primary cause of death in the industrialized world.
SIGNIFICANCE : Immediate dentin sealing protocol is recommended whenever dentin is exposed during the preparation for thin glass-ceramic occlusal veneers.
SIGNIFICANCE : In amnesic MCI patients , global EEG functional coupling is basically low in amplitude and does not react to hypercapnia.
SIGNIFICANCE : In conclusion , major components of CNSL yield overall best dentin biomodification outcomes when applied for one minute without staining the dentin collagen.
SIGNIFICANCE : In most of the previous publications , uncertainty was not considered in the regression model of bone Pb and age.
SIGNIFICANCE : In vitro , hydrolytic degradation supports mechanical fatigue in dentin-composite bonds over time.
SIGNIFICANCE : It is a well-established scientific observation that mammalian cells contain fidelity or watchdog proteins that maintain the correct function of cellular organelles.
Significance level was defined p < 0.05.
SIGNIFICANCE : Locomotor adaptation therapy may be effective in ameliorating asymmetric gait deficits in persons with PD.
SIGNIFICANCE : Maintenance of metabolic homeostasis is critical for cellular and organismal health.
SIGNIFICANCE : Many genotoxic chemotherapies have debilitating side effects and also induce cellular senescence in normal tissues.
SIGNIFICANCE : Memory is an essential human cognitive function.
SIGNIFICANCE : Mitochondria are complex dynamic organelles pivotal for cellular physiology and human health.
SIGNIFICANCE : Mitochondria utilize most of the oxygen to produce adenosine triphosphate via electron transfer coupled with oxidative phosphorylation.
SIGNIFICANCE : NF jiggle derived from DQEMG can be a useful method of identifying neuromuscular dysfunction at various stages of MU remodeling and aging.
SIGNIFICANCE OF RESULTS : Findings can inform the development of individualized educational programs and interventions for family caregivers.
SIGNIFICANCE : Older people reporting spinal pain have @percent@ increased risk of mortality per year lived.
SIGNIFICANCE : Our findings provide original insights into the definition of the ' normal ' behavior of age-related MEG spectral patterns.
SIGNIFICANCE : Our results support the notion of a progressive defect in SCH , which does not contradict the existence of a basic neurodevelopmental alteration.
SIGNIFICANCE : Our study is the first to clarify a difference between children and adults in the perception of facial emotional change.
SIGNIFICANCE : Overall , these results demonstrate that curcumin-induced mild ER stress increases osteoblast differentiation via ATF6 expression in C3H10T1 / 2 cells.
SIGNIFICANCE : Oxidative stress and damage are well-established components of neurodegenerative diseases , contributing to neuronal death during disease progression.
SIGNIFICANCE : Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease.
SIGNIFICANCE : P300-based BCI performance in people severely disabled by ALS is similar to that of age-matched control subjects.
SIGNIFICANCE : Plants produce many small molecules with biomedical potential.
SIGNIFICANCE : Previous and forthcoming clinical studies using complexity estimates might be interpreted from a more complete and dynamical perspective.
SIGNIFICANCE : Recommendations based on the results are provided regarding device designs for BR estimation , and clinical applications.
SIGNIFICANCE : ROS , which are known to be present in vivo , can create structural damage and change electrical properties of MEAs.
SIGNIFICANCE : Selenium is utilized in the methionine sulfoxide reduction system that occurs in most organisms.
SIGNIFICANCE : Spectral biomarkers may have both diagnostic and prognostic value.
SIGNIFICANCE STATEMENT : Astrocytes play a central role in CNS function and associated diseases.
SIGNIFICANCE STATEMENT : Children show substantial individual differences in math abilities and ease of math learning.
SIGNIFICANCE STATEMENT : During early language acquisition , typically developing infants gradually construct phonemic maps of their native language in auditory cortex.
SIGNIFICANCE STATEMENT : Face perception , which is critical for daily social interactions , develops from childhood to adulthood.
SIGNIFICANCE STATEMENT : Frontal , striatal , and medial temporal functions implicated in value-based decision processing of rewards and costs undergo substantial age-related changes.
SIGNIFICANCE STATEMENT : Glycosylation is the key posttranslational mechanism that regulates function of immunoglobulins , with multiple systemic repercussions to the immune system.
SIGNIFICANCE : Stimulus properties need to be considered when deciding the most appropriate way to investigate vestibular function using oVEMPs.
SIGNIFICANCE : Storage of Kalore GC in dry air , water or heptane at 37°C for @number@ days caused post-curing reactions.
SIGNIFICANCE : Surface transformation was evident , which can lead to rougher surfaces and increased wear of opposing dentition / materials.
SIGNIFICANCE : Tau may be an age-independent factor of accelerated neurodegeneration , with effects differing by types of neurons and regions of the retina.
SIGNIFICANCE : The accepted effects of aging in mammalian skeletal muscle are progressive atrophy and weakening , or sarcopenia.
SIGNIFICANCE : The advent of child-sized whole-head MEG systems opens new opportunities for the study of cognitive brain development in young children.
SIGNIFICANCE : The application of EDC to acid-etched dentin helps maintain the viscoelasticity of hybrid layers.
SIGNIFICANCE : The EEG photic driving can reveal functional topographic alterations not present in the spontaneous EEG.
SIGNIFICANCE : The expression of nodal KCNQ channels appears to be greater in females.
SIGNIFICANCE : The high variability of bond strength test results highlights the need to establish individual acceptance levels for a given test institute.
SIGNIFICANCE : The incidence of cardiovascular events ( CVEs ) increases with age , representing the main cause of death in an elderly population.
SIGNIFICANCE : The molecular mechanism of aging is still vigorously debated , although a general consensus exists that mitochondria are significantly involved in this process.
SIGNIFICANCE : The nematode Caenorhabditis elegans is a widely used model organism for research into aging.
SIGNIFICANCE : The neonate's brain development during the first weeks of life can be traced from changes in the characteristics of EEG functional connectivity.
SIGNIFICANCE : The resin containing DMAEMA showed higher DC , shrinkage-strain , shrinkage-strain rate , and microhardness , in addition to better optical properties.
SIGNIFICANCE : These findings provide clinical implications for conditions restricting the use of one limb , such as stroke.
SIGNIFICANCE : These normative data sets provide a firm basis for planning clinical studies.
SIGNIFICANCE : These results illustrate how measures of otolith function change with age in community-dwelling adults.
SIGNIFICANCE : The study indicates long-range communication impairments in the aged brain and the results are discussed considering hypotheses on increases in neural noise.
SIGNIFICANCE : This article is the first to investigate the nature of medication cost discussions between ophthalmologists and glaucoma patients.
SIGNIFICANCE : This study provides for the first time a neurobiological explanation for the age related changes of the MMN in the ageing brain.
Significance was accepted at P < @number@
SIGNIFICANCE : We provide the first electrophysiological evidence for age-related changes in oscillatory neural activities across the somatosensory areas.
Significant aesthetic improvements on the treated sides were observed at all visits , with the exception of the décolletage at week @number@
Significant age and gender interactions were found to influence the relationship between age-stereotypes and internal health locus of control.
Significant age-related changes included local expansions of regions low in volumetric bone mineral density ( vBMD ) and local contractions of regions high in vBMD.
Significant amelioration of motor and cognitive functions was revealed in young , but not aged , Tx and CM groups.
Significant association between CAVI≥9 and male subjects or age was recognized.
Significant association between paraseptal emphysema and interstitial lung abnormalities was observed.
Significant association of cataract risk with highest versus the lowest category of serum ascorbate was found in general [ @number@ ( @number@.564-0.879 ) ] .
Significant association of the TPH2 genotype with Neuroticism and Conscientiousness was found at age @number@ and with Extraversion and Conscientiousness at age @number@
Significant associations between age and function were observed for many functions.
Significant associations between age and function were observed for many functions.
Significant associations may exist between mastication and higher brain function among the elderly.
Significant associations were also found after adjusting for anxiety , anger , or depression and after controlling for positive affect.
Significant associations were detected between human lifespan and SNPs in genes SIRT3 , SIRT5 , SIRT6 , FOXO3 and SOD3.
Significant associations were found between amplitude of the responses and both age of L2 acquisition and years of L2 experience.
Significant associations were found between hsCRP and childhood social adversity in the Canadian but not in the Latin American samples.
Significant associations were found only in ApoE e4 noncarriers ( n = @number@ ) .
Significant bias and Type I error rates in the estimated effects of retest were observed when these convergence assumptions were not met.
Significant biofilm formation was observed on MTA and Dycal.
Significant changes in HTR2A expression with age were found in frontal cortex , amygdala , thalamus , brain stem and cerebellum.
Significant changes in most of the examined variables documented the positive effects of the program.
Significant changes in opioid doses were reported with an inverse relationship with age ( p = 0.0001 ) .
Significant changes in the voice occur after the age of @number@ years.
Significant changes were found for @number@ proteins involved in crucial neuronal process such as energy metabolism or signal transduction.
Significant changes were not detected for antioxidant-related genes.
Significant clusters were found only under the condition of some of the NC combinations but not under the others.
Significant combinations were defined as type profiles and used in simulated accessibility analyses.
Significant correlation between age and morphology was found.
Significant correlations between methylation level and age were identified in four of the seven regions.
Significant correlations between sagging index and RRT values were found for 110-170° and 290-350° only at the center of the cheek.
Significant correlations between these factors and thermal sensitivity were not established.
Significant correlations emerged between the three clusters of measured variables.
Significant correlations were also found between EEG and movement kinematic measures.
Significant correlations were detected between all measures of TMS and static steady-state balance ( r = .43-.57 , p < @number@ ) .
Significant correlations were found between FS and endurance , agility-dynamic balance , upper and lower limbs muscle strength tests.
Significant correlations were found between MNA-SF and the full version ( r = 0.916 ; p < @number@ ) .
Significant correlations were found between muscular strength , cardiorespiratory fitness , and neuromuscular economy ( r = @number@.43-0.64 , p < @number@ ) .
Significant correlations were found between SPY and PWV , augmentation indices , and AA , respectively.
Significant correlations were found between the RCPM test , the VerPA task , the Block Design test and masticatory ability.
Significant correlations were observed between specific measures of TMS and dynamic steady-state balance ( r = .42-.55 , p < @number@ ) .
Significant correlations were observed between the extent of chest X-ray infiltration and CRP levels in both CAP and pneumococcal pneumonia.
Significant correlations were observed between the result of the two questionnaires and these hormone levels.
Significant correlation was observed between prostate cancer and methylation level of RARβ2 gene promoter.
Significant cortical bone loss occurred after midlife.
Significant decreases in connectivity were found across AD variants compared with controls in the non-DMN networks.
Significant decreases in the synovial fluid total protein concentrations were observed after the second dosage of high molecular weight hyaluronic acid injections.
Significant decreases were observed with FM only in the dairy supplement group ; no changes were observed for any other variables.
Significant decrement of cortisol ; ACTH ; and increment in serotonin , dopamine , and BDNF was noted following yogic practice.
Significant design characteristics included sidewalks ( β = @number@ p < @number@ ) and crime ( β = @number@ p < @number@ ) .
Significant diet correction was achieved after 18-month follow-up in the intervention group , comparing to controls.
Significant difference ( F = 32.702 ; p = 0.001 ) was found in the endurance time across the age groups.
Significant differences and correlations were also identified for BMI , UAC and MNA-SF.
Significant differences between MCI and AD were essentially confined to the corpus callosum.
Significant differences between skin locations and to a lesser extent age groups and gender were demonstrated.
Significant differences by sex were noted for weight , BMI , ALT , total bilirubin , and indirect bilirubin.
Significant differences existed between minority and middle age groups in all above-mentioned parameters ( P < @number@ ) .
Significant differences in all the above parameters were also found in patients with moderate OSA compared to those with mild OSA.
Significant differences in CMRgl co-variations in AD and MCI groups as compared to NC were found.
Significant differences in demographic , lifestyle and health outcomes were associated with class membership.
Significant differences in health status variables , but not in well-being were detected between groups.
Significant differences in hearing threshold changes existed for pilots with @number@ or more years of service compared to those in other categories.
Significant differences in mean μ ( MRE ) and μ ( PWV ) between young and old healthy volunteers were observed.
Significant differences in pharmacotherapeutic prescribing were noted depending on the stage of disease progression and the number of years working as a GP.
Significant differences in Q wave amplitude , duration and area were identified both by sex and level of participation.
Significant differences in RRT values were noted for 110-150° and 300-350° at this site between subjects with and without the use of YAC extract.
Significant differences in sedentary behaviours between stratified groups were only detected with the SenseWear.
Significant differences in the expression of nine proteins ( @percent@ ) in the resting platelet proteome were observed in children compared to adults.
Significant differences in the expression of numerous plasma proteins between healthy children and adults have been recently demonstrated.
Significant differences in the profile of consumption were identified between men and women , with more abusive use among men.
Significant differences occurred due to speed for all muscles ( p < .0001 ) .
Significant differences persisted after adjustment for age , sex and self-reported health.
Significant differences were also seen between high-speed and standard-speed yoga for volume of oxygen consumed and carbon dioxide produced.
Significant differences were found according to diabetic complications in specific Audit of Diabetes-Dependent Quality of Life items and impact scores.
Significant differences were found in BMI and %fat mass , between BBP and S with relation to LDR ( p < 0.001 ) .
Significant differences were found in the number and viability of cells that were transferred as a full sheet , depending on the transfer method.
Significant differences were not detected by quantification of Lineage trees.
Significant differences were observed among all test groups ( P < @number@ ) .
Significant differences were observed between the basal insulin groups for glycated hemoglobin level and dosing frequency.
Significant differences were observed between the hearing results obtained with the application and the standard audiogram at all frequencies and in both ears.
Significant differences were observed in the built environment features of the three countries and in particular between Finland and the other two.
Significant differences were observed in therapeutic strategies utilized with the two groups , but the overall survival was not significantly different.
Significant differences were observed in the tear meniscus borderline , TMA , and tear transparency between the @number@ groups.
Significant differences were only found in distribution of diagnoses between the two centers in joint consultations.
Significant differences were shown in facial tissue depth between Mi'kmaq and White Americans and Mi'kmaq and African Americans.
Significant difference was detected regarding the pain intensity for mandibular incisors only ( p < @number@ ) .
Significant drop in EF was seen at @number@ weeks after PB , with gradual decline thereafter.
Significant DS-CVD interactions were observed cross-sectionally ( but not longitudinally ) for figural memory and fine motor speed.
Significant DTI changes were also tested for correlations with changes in clinical measures , dopaminergic imaging and CSF biomarkers in PD patients.
Significant effect of BFR was seen in IWA but not in RWA.
Significant effect size was observed in lateral and medial but not orbital PFC.
Significant excess mortality before age @number@ years was also observed for infections , vascular deaths , cancer , alcohol-related deaths and suicide.
Significant factors among only rural residents were gender and cognitive function.
Significant factors for the age slopes for women were stress , smoking and dementia.
Significant gender and nativity differentials emerge.
Significant group main effects were also found , with aMCI recalling less than controls.
Significant health benefits were even seen among participants who became physically active relatively late in life.
Significant health care resources are required for all fractures.
Significant hemodynamic changes ensue with aging , leading to an ever-growing epidemic of hypertension.
Significant heterogeneity in the results of the quantitative studies precluded statistical data synthesis.
Significant higher Er was observed for PACs and EDC / NHS groups at the hybrid layer after 24h.
Significant IADSBP is associated with increased arterial stiffness in community-dwelling older adults.
Significant improvement in survival for younger patients was demonstrated with adjustment for recursive partitioning analysis ( RPA ) class.
Significant improvements in mood and disability were consistent , although evidence of changes in cognitive measures is controversial , less studied , and limited.
Significant improvements in reported attitudes , confidence , and practices were found across measured items.
Significant improvements in this issue took place between @number@ and @number@ thanks to the Dependency Law ( @number@ ) .
Significant improvements on the TMT-B test occurred after passive leg cycling.
Significant improvements were evident in the AOFAS scores , and the VAS scores decreased , in both groups.
Significant improvements were found in attention / executive function and memory abilities 12-weeks and 12-months after surgery.
Significant improvements were found in upper and lower musculoskeletal fitness and partial curl-ups , with TC being embraced by the participants.
Significant improvement was maintained in investigator-assessed NLF severity at @number@ months , and investigators and subjects reported high satisfaction with VYC-17.5L throughout the study.
Significant improvement was noted in objective assessment of post-test aggregate scores ( Mean difference @number@ @percent@ CI @number@.52-3.77 , p = @number@ ) .
Significant increased mTOR protein levels were determined in old tissue and cells.
Significant increase in serum alanine transaminase in both sexes and bilirubin only in male suggests the eventuality of hepatic disintegration.
Significant increases have occurred in the incidence of colorectal , thyroid , female breast , and prostate cancers.
Significant increases in perceived proficiency in these competencies occurred , as did significant decreases in negative attitudes toward older people and working with older adults.
Significant increases in physical activity participation were maintained among participants who were physically inactive at baseline.
Significant increases in self-efficacy and morale were observed for program completers.
Significant independent predictors of mortality , regardless of ethnic group , were diabetes mellitus with complications , comorbidity , depressive symptoms , and cognitive impairment.
Significant individual variability of the macro and trace elements ' status of children-northerners and some gender dependence were revealed.
Significant interactions between AA and EPA + DHA intakes were observed cross-sectionally in women and longitudinally in men.
Significant interactions between GS and CMD were observed for all functional measures with 20%-30% of observed ORs attributable to additive interaction.
Significant interactions between social support and negative interaction showed that social support buffers against the harmful effects of negative interaction on suicidality.
Significant interactions were found between PTSS and each health measure , suggesting that health only predicts subjective age for those reporting high PTSS.
Significant intercorrelations were observed among the morphologic indices with univariate analysis for given ROIs.
Significant interpopulation and sex-specific longevity differences among human populations appear enigmatic biodemographic phenomenon.
Significant intrinsic fall risk factors for elderly people are orthostatic and postprandial hypotension.
Significant levels of heteroplasmy were identified at @percent@ of sites evaluated.
Significant linear regressions were identified , but there was no significant difference in the rate of increase in both sexes.
Significantly , ablation of type-1 interferon-α receptor @number@ expression in BE ( @number@ ) M17 neuroblastoma cells and primary neurons afforded protection against Aβ-induced toxicity.
Significantly better outcomes were noted in all cognitive test scores among those with higher walnut consumption ( P < @number@ ) .
Significantly correlated ( p < 0.002 ) variables were entered into a multiple linear regression.
Significantly , decreased iFC in PD-CI patients compared with control subjects was observed , predominantly between major nodes of the default mode network.
Significantly deregulated miRNAs and mRNAs were correlated and examined for potential binding sites ( in silico ) .
Significantly different 3DCε and 3DRε values were obtained with vendor-independent versus Vsp 3D STE ( P < @number@ ) .
Significantly fewer women died in the response group than in the population as a whole.
Significantly greater deactivations from baseline were observed for the Top group than for the Novice group in the right medial prefrontal cortex.
Significantly greater hippocampal atrophy was observed for participants reporting a life-changing religious experience.
Significantly greater variability was found in the 7-9 group compared to the 13-16 years.
Significantly higher age-adjusted oral cancer incidence rates are observed in suburban neighbourhoods from @number@ to @number@ accompanied by rising socioeconomic deprivation in those areas.
Significantly higher crude prevalence of obesity , abdominal obesity , dyslipidemia , and metabolic syndrome among women compared with men persisted from 2002-2003 to 2011-2012.
Significantly higher knee pain was reported in the involved knee than in the contralateral knee , as determined by a visual analog scale.
Significantly less severe pain / tenderness was reported with HA ( E ) than with HA ( P ) ( P < 0.05 ) .
Significantly , long-lived animals with reduced insulin / IGF-1 signaling abrogate stress granule RBP aggregation through activation of the transcription factors HSF-1 and DAF-16.
Significantly , loss of MDM2 in Ptch1 ( + / - ) mice , a model for Shh-mediated human medulloblastoma , impedes cerebellar tumorigenesis.
Significantly lower levels of C-reactive protein ( CRP ) and fibrinogen ( FBG ) provided confirmatory evidence for a population difference in proinflammatory activity.
Significantly lower levels were observed thereafter.
Significantly more participants from the SHA setting were at risk of malnutrition compared to the home-living setting.
Significantly more patients with different forms and grades of age-related hearing loss had abnormal tympanometry and absent acoustic reflex.
Significantly more patients with loss of appetite live alone.
Significantly more women than men were institutionalized , although for women the move occurred later in life.
Significantly , prolonged or inappropriate inflammatory responses contribute to the pathogenesis of these diseases.
Significantly , resveratrol activates SIRT7 deacetylase activity , inhibits breast cancer lung metastases , and increases survival.
Significantly , selenium supplementation inhibited differentiation by increasing ROS-scavenging selenoenzyme biosynthesis because glutathione peroxidase @number@ and TXNRD1 expression and TXNRD1 enzyme activity were restored.
Significantly , the CISD2 gene is located within the candidate region on chromosome 4q where a genetic component for human longevity has been mapped.
Significantly , the clinically relevant mutations perturbed ChlR1 DNA unwinding activity.
Significantly , the induction of senescence by angiotensin II was abrogated by rotenone and by the mitochondria-targeted superoxide dismutase mimetic , mitoTEMPO.
Significantly , these findings showed age- and genetically-modulated changes in dual-task postural displacement in the medio-lateral direction in female PM-carriers.
Significantly , we discovered new global pathway activation signatures of AMD involved in the cell-based inflammatory response : IL-2 , STAT3 , and ERK.
Significant main effects for age and reverberation were not found for ANL or MCL.
Significant main effects of noise type , SNR , and group were found.
Significant main effects were observed for the velocity response for hand placement technique and age group.
Significant monthly differences in birth number ( q2 = 21.077 , p < 0.03 ) were observed.
Significant negative change over time was observed for all cognitive and brain measures.
Significant negative correlation between cadaver age and the CT value or cortical bone thickness was observed only among the female samples.
Significant negative correlations between cadaver age and sample thickness , ST / CS , and the sample density were observed only among the female samples.
Significant non-invariance was identified in each of the age group analyses.
Significant ( p < .0125 ) group interactions were found for all PC scores.
Significant pain associated with this second day exposure was an indication to return indoors immediately.
Significant positive associations were found with maternal smoking before and during pregnancy and during the first and sixth year of life.
Significant positive correlation was observed between the area of the somatotropes and volume density of type @number@ muscle fibers.
Significant power interactions between cannabis exposure and the square and cube of CA were demonstrated ( from p < 0.002 ) .
Significant predictors of homeless program completion assessed from univariate models were then evaluated in multivariate models.
Significant predictors of sedentary behaviours were not identified.
Significant prevalence of risk factors was established in men with myocardial infarction in St. Petersburg.
Significant progress has been made in understanding the neurobiological mechanisms through which exercise protects and restores the brain.
Significant progress has been made uncovering functional brain networks , yet little is known about the corresponding structural covariance networks.
Significant public interest focuses on questions like : how does my child grow ?
Significant reduction in the NRC was found in PD as compared with @number@ age- and sex-matched normal volunteers.
Significant reduction of the NRC was demonstrated in patients with visual hallucinations as compare with patients without the symptoms.
Significant reductions in context memory retrieval accuracy were observed in MA , compared with YA.
Significant reductions were present in the bilateral frontal white matter / cingulate gyrus and the posterior limb of bilateral internal capsule.
Significant regional differences in gray and white matter volume and subtle cognitive differences between young diabetic and nondiabetic children have been observed.
Significant regional differences in the SR indices was seen in passive joint rotation ( P < @number@ ) for both cohorts.
Significant region of interest and voxel-wise gray matter volume associations were observed for the high frequency hearing construct.
Significant relationship between risks of MOF , falls , and death and the modified PF model was found.
Significant relationships were observed between task performance and age and sex , although the contributions of both factors differed by varying degree.
Significant self-efficacy by education interactions indicated that associations between self-efficacy and executive abilities were stronger for individuals with lower education.
Significant social differences were observed for premature and total mortality.
Significant systemic inflammation developed in aging Nlrp3 mutant Il18r-null mice , indicating that IL-1 and IL-18 drive pathology at different stages of the disease process.
Significant thresholds were found for all three variables , and also for total motile count ( TMC ) in the prepared sperm.
Significant time effects were present for CK , elbow extension , elbow flexion , arm volume , and soreness.
Significant topographical variations in thickness of each of the retinal layers were also observed ( P < @number@ ) .
Significant treatment engagement barriers were the older adults ' lack of motivation , denial of depression , perceived stigma , and other personal attitudinal factors.
Significant Trp fluorescence quenching occurs on interaction of the green tea component , EGCG with HGC ( c ) accompanied by a red shift.
Significant ultrasound differences were registered between the patients with traumatic and atraumatic onset of neck pain.
Significant variables after Bonferroni adjustment were further considered in a multivariate Cox regression analysis.
Significant variables of loneliness were social support received from spouse , social support provided to spouse , and children living together with both elderly parents.
Significant WM changes in the left intrafrontal and frontostriatal pathways were found in nfvPPA , but not in the semantic or logopenic variants.
Significant WMH increases were observed in all selected regions , particularly within the corona radiata.
Signs indicate the importance of bronchial hyperreactivity ( BHR ) as a key factor.
Signs of backlog and deformation of development of the nervous system , determining a disadaptation of the child are taped.
Signs of hyperandrogenism may appear in postmenopausal women due to tumorοus and non-tumorοus adrenal and ovarian causes as well due to the normal aging process.
Signs of mucosal senescence first appear in the gut immune system.
SI increase was selectively associated with CAP phases.
SI in the past @number@ weeks and @number@ months were assessed.
Sildenafil citrate ( Viagra ) , a phosphodiesterase @number@ inhibitor ( PDE5i ) , is a commonly prescribed drug for erectile dysfunction.
Silencing Chemerin in senescent fibroblasts or the CCRL2 and GPR1 receptors in the SCL-1 cSCC cell line abrogates the Chemerin-mediated chemotaxis.
Silencing MDMX induces RB accumulation , cell cycle arrest and senescence-like phenotypes , which are reverted by simultaneous RB knockdown.
Silencing of Ago2 in ATSCs significantly induces upregulation of miR10b and miR23b expression.
Silencing of CYP27B1 and VDR significantly blunted the stimulating effect of spironolactone on KLOTHO mRNA levels in HEK293 cells.
Silencing of GATA6 gene expression up-regulates caveolin-1 expression , whereas overexpression of GATA-6 protein sustains the transcriptional repression of caveolin-1 in bladder smooth muscle cells.
Silencing of GLP-1R gene expression by siRNA significantly blocked the effects of liraglutide in ALP protein expression and PI3K / Akt phosphorylation.
Silencing of SDC1 in liposarcoma cells impaired cell viability and proliferation.
Silencing of SOX5 in human SH-SY5Y neuroblastoma cells resulted in a significant repression of WNT signaling activity and altered expression of WNT-related genes.
Silencing of the histone acetyltransferase Mof , which specifically acetylates H4K16 , down-regulates Nox4 gene / protein expression.
Silencing REGγ abrogated this response in multiple cell lines.
Silencing S6K1 in senescent cells reduced superoxide generation and enhanced NO production.
Silencing TDP-43 itself is probably not appropriate , given its critical cellular functions.
Silent information regulator @number@ ( Sir2 ) orthologs are an evolutionarily conserved family of NAD-dependent protein deacetylases that regulate aging and longevity in model organisms.
Silent mating type information regulation @number@ homolog @number@ ( SIRT1 ) , a NAD-dependent deacetylase , mediates cellular processes involved in gene silencing and aging.
Silica coating was only sufficient after @number@ d of water storage and when combined with phosphate-esters or phosphone-containing primers.
Silodosin is administered once daily and provides rapid improvements in the signs and symptoms of moderate to severe LUTS / BPH in male patients.
Silymarin is a flavanone derivative extracted from the seeds of the milk thistle Silybum marianum.
SI may be a risk factor for hip fracture in Chinese women.
SI may be a risk factor for hip fracture that is independent of BMD measurement in Chinese women.
Similar age-related volumetric changes were not found for PCA ( p = @number@ ) .
Similar analyses revealed no significant between-group differences for statin or thiazide use.
Similar analyses were used to determine predictors of profile membership.
Similar associations related to frequent ( daily or weekly ) consumption were also identified.
Similar associations were detected among APOE ε4 allele carriers and noncarriers.
Similar associations were found between sUA and IMT , but only in men.
Similar associations were found for changes over @number@ years in serum T and decline in sexual desire , but not for erectile function.
Similar associations were observed among the younger participants and those with @number@ to @number@ or @number@ to @number@ teeth.
Similar associations were observed for cancer mortality.
Similar associations were observed regardless of heart rhythm or receipt of beta-blockers.
Similar associations were observed when fitting accelerometry-based PA as a time-dependent variable.
Similar associations were observed with survival.
Similar benefit of chemotherapy was found for CRC outcomes in both the CIMP-low / negative group and the CIMP-high group.
Similar cells accumulate at younger ages in persons chronically infected with HIV-1.
Similar changes are found in a more pronounced form in age-related macular degeneration.
Similar changes have also been observed for saccular responses evaluated through Cervical vestibular evoked myogenic potential ( cVEMP ) after the age of @number@ years.
Similar changes have been reported for several animal species and are thought to facilitate age discrimination of an individual based on body odors , alone.
Similar changes in extracellular Aβ deposits and MAP2 positive cells were also seen in the hippocampus.
Similar changes in the hemostatic system with aging are observed.
Similar CVF and LVF associated to greater myocyte size and LVM in male rats suggest a process of physiological response.
Similar degrees of conversion were attained in control and experimental groups for CSE.
Similar difference was found in both genders.
Similar dose intensities were delivered to the elderly and younger.
Similar effects in physical function were observed using the SPPB.
Similar effects of self-rated health emerged for both types of stimuli.
Similar effects were also observed when the myosin molecules extracted from muscle fibers were exposed to oxidative stress.
Similar effects were observed for the peak concentrations of EAA and total AA ( TAA ) .
Similar effects were observed upon ROS ablation via the antioxidant N-acetylcysteine confirming ROS as the mediators.
Similar effect was observed with theobromine , besides its antioxidant capacity inducing SOD-1 and GPx expression.
Similar features between the immune system of healthy elderly people and of younger individuals subjected to conditions of chronic immune activation are progressively being observed.
Similar figures were observed in @number@ young controls ( @number@ yr ) .
Similar findings are also reported for major hepatic resection in elderly patients with either hepatocellular carcinoma ( HCC ) , Klatskin tumour or gallbladder carcinoma.
Similar findings for controls were made across all ages , spanning from infants to the elderly.
Similar findings resulted when HbA1c was further adjusted for BMI.
Similar findings to those seen in Tg2576 mice were found in apoE4 , but not in apoE3 mice.
Similar findings were not observed in mice or dogs at much higher exposures.
Similar findings were observed among ex-smokers and current smokers.
Similar findings were observed for females.
Similar findings were observed for men and for hip fracture.
Similar findings were observed in a subgroup analysis consisting of patients with a pancreatic duct diameter smaller than @number@ mm.
Similar findings were observed regardless of whether all included studies , or only those evaluating patients with atrial fibrillation , were assessed.
Similar glomerular abnormalities have been described in autopsied preterm infants.
Similar improvements were observed for heart failure and acute myocardial infarction.
Similar improvements were obtained in KKA ( y ) genetically diabetic mice.
Similar increases have recently been reported in false memory for complex , realistic life events , using forensically oriented paradigms.
Similar increases were seen in HepG2 cells following treatment with OTC.
Similar indices can be created in existing datasets to identify frail individuals and where appropriate account for frailty , an often unmeasured confounder.
Similar insignificant results were found for yield load and linear stiffness.
Similarities and differences in the relationship of glucocorticoid hormones to psychiatric symptoms in these conditions will be reviewed.
Similarities in aging processes and prediction methodologies have been identified between human aging and aircraft aging.
Similarities were highest over shorter age ranges and when external features were concealed.
Similarity between the sinusoidal and lymphatic endothelium includes the fact that both types are LYVE-1 positive and CD34 negative.
Similarity in oldest parturitions in humans and great apes suggests that we maintain ancestral rates of ovarian aging.
Similar levels of alpha-synuclein accumulation in mitochondria were detected in the ventral midbrain , striatum and cortex of Thy1-aSyn mice.
Similarly , 1M chip array outperformed 610K and 317K.
Similarly , 20 / 366 coding synonymous were identified in ND related genes , mostly epigenetic.
Similarly , 25 ( OH ) D levels were not significantly related to anxiety symptoms after three years in both samples.
Similarly , a best practice for the anesthetic management of patients with AD is not yet defined.
Similarly , adult epidermal stem cells have the capacity to renew epidermis , the fully differentiated , protective envelope of our body.
Similarly , adults of all ages used comparable decision strategies and adapted their strategies to the demands of the task.
Similarly , AFP had sensitivity = @number@ specificity = @number@ PPV = @number@ and NPV = @number@
Similarly , aging results in a reduced acute testosterone response to resistance exercise in men.
Similarly , allostatic load ( AL ) , the ' wear and tear ' of chronic stress , is associated with inadequate HPA axis activity.
Similarly , anchor-based MICs of the Lawton IADL scale were between @number@ and @number@ points and distributional MICs ranged from @number@ to @number@ points.
Similarly another study showed that atrial fibrillation was significantly associated with conversion from mild cognitive impairment to dementia during a @number@ years follow-up.
Similarly , antihypertensive and antihyperglycaemic drugs ( pioglitazone and insulin ) have been shown to reduce the risk of Alzheimer's disease or disease progression.
Similarly , antipsychotics and mood stabilizers have no proven efficacy for depression and the risk of adverse effects seems to outweigh any potential benefit.
Similarly , applying the same segmentation to PD population , we were able to isolate these activities within ~500 ms of the visual segmentation.
Similarly , arterial stiffness indices of the PTA remained unchanged after the exercise , whereas HR increased significantly ( p < @number@ ) .
Similarly , a social vulnerability index was created using @number@ self-reported social deficits.
Similarly , associations have been reported between testosterone levels and psychotic symptoms.
Similarly , atrophy was not observed in the caudate and pallidum despite marked amyloid accumulation.
Similarly , being on nonaspirin antiplatelets was protective against in-hospital mortality ( P = @number@ ) .
Similarly , bilingualism is also considered to be a safeguard.
Similarly , calcium channel blockers ( CCBs ) also have clearly shown protective effect of cardiovascular system , especially as it regards cerebrovascular disease risk.
Similarly , caspase-8 has dual role in cell death , mediating both receptor-mediated apoptosis and in its absence , necroptosis.
Similarly , cognitive inhibition abilities explained inter-individual variability in number-space associations over and above the factors age , WM capacity and response speed.
Similarly , connectivity of the anterior hippocampus to the right superior temporal lobe and IFG was uniquely linked to subsequent memory of intentionally encoded associations.
Similarly , coordinated changes of the nuclear membrane and endoplasmic reticulum may also help unravel the regulatory mechanisms of RNP dynamics.
Similarly , Cross-ApEn results also showed differences between all groups , with ET persons showing strongest inter-limb coupling followed by PD and elderly.
Similarly , Crp expression is also suppressed in fasted and diet-restricted liver.
Similarly cytoplasmic localization of phosphorylated p38 in KGN cells was observed after treatment with H ( @number@ ) O ( @number@ ) .
Similarly , differences between previously exposed ( n = @number@ ) and unexposed ( n = @number@ ) retired women tended to reduce with age.
Similarly , drug combinations that may cause DDIs decreased by @number@ % and antipsychotics by @number@ %.
Similarly , earlier and later maturation ages were accompanied by increased and decreased energetic investments into early fecundity , respectively.
Similarly , eHSP72 reduced β-cell viability ( at least @percent@ for BRIN-BD11 and @percent@ for @number@.1B4 cells ) .
Similarly , environmental neurotoxicants that are implicated in the etiology of age-related neurodegenerative conditions cause regionally specific damage in the brain.
Similarly , expression of OSKM in vivo improves recovery from metabolic disease and muscle injury in older wild-type mice.
Similarly , FACIT-F scores were higher for married patients than for widowed ones , and they were age-dependent.
Similarly , FCD2-linked families display an exponential trend in severity with age , as was observed in a family linked to FCD1.
Similarly , for every increase in @number@ units in GL , the PAIx75 increased by @number@ ( @percent@ CI : @number@ @date@ ) .
Similarly , for those considered at risk for frailty , each social deficit was associated with a @percent@ increased risk of mortality.
Similarly , glycated apoA-I ( gA-I ) by fructosylation has a covalently multimerized band without a crosslinker and impaired phospholipid-binding ability.
Similarly , greater EA predicted greater use of suppression , but only among women with greater vagal flexibility.
Similarly , having children only improves the life-satisfaction of lower educated older adults.
Similarly , higher socioeconomic status was associated with greater height and a greater secular increase in height.
Similarly , HIV infection is associated with fatty liver as a result of multiple viral and host factors.
Similarly , HTN increased proportionately with the participant's body mass index.
Similarly , IGF1 signaling reduction protects mice from AD-like disease.
Similarly , in age-related hearing loss , degeneration of cochlear synapses precedes both hair cell loss and threshold elevation.
Similarly , increased expression of Sirt1 in Tie2 expressing vascular endothelial cells and monocytes / macrophages does not protect retinal vessels in OIR.
Similarly , inhibiting autophagy would contribute in the treatment of cancer.
Similarly , intermediate molecular weight oligomeric species displayed an increase in aged and Alzheimer brains when compared with the young using two amyloid-β42 antibodies.
Similarly , interviews with members of the research team highlighted the dual nature of their positions as researchers and as clinicians.
Similarly , in the fast gait condition older adults lacked the strength to match the plantar flexor torque produced by young adults.
Similarly , it correlated with the changes in @number@ RM in YT.
Similarly , its levels increase with aging and are related to impaired survival in elderly adults.
Similarly , levels of the major anticoagulant proteins are low at birth.
Similarly , long-term prevention of stroke risk among diabetic patients is not improved with glucose-lowering therapies.
Similarly , lung disease was a predictor only for MA.
Similarly , microfold ( M ) cells involved in the antigen ( Ag ) uptake are ideal targets for facilitating Ag-specific mucosal immune responses.
Similarly , mitochondrial-anchored ubiquitin is sufficient to recruit p62 and promote mitochondrial clustering , but does not promote mitophagy.
Similarly , most classes of higher organisms have been shown to have some version of a central stress-mediating transcription factor , NF-κB.
Similarly , neovascular age-related macular degeneration ( nAMD ) affects older patients and is a leading cause of irreversible visual loss.
Similarly , neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients , relative to the two other groups.
Similarly , no data are available about the reasons to ED visit and its role in determining the ED utilization pattern.
Similarly , no significant changes ( P > 0.05 ) were observed following the detraining period compared with the standard-care group.
Similarly , no significant correlation was observed between renal cortical thickness and age ( r = @number@ P = @number@ ) .
Similarly , @number@ studies employed prescription reviews , whereas @number@ studies employed clinical medication reviews.
Similarly , older adults with LV were more likely to have high-risk levels of homocysteine compared to older adults with normal vision.
Similarly , overweight increased the risk for categories of mild impairment of cognitive function and likely dementia.
Similarly , oxylipins derived from the ω-6 fatty acid linoleic acid generally have more adverse than beneficial cardiovascular effects.
Similarly , patients on drug regimens , which tend to lessen the side effects , report better QOL.
Similarly , patients treated with warfarin carry a greater risk of developing osteoporosis and fractures , due to reduced BGP activity.
Similarly , pegvisomant supplementation had no effect on mRNA expression of IGF-I and collagen in skeletal muscle.
Similarly , peripheral peptides ( e.g. , ghrelin , glucagon-like peptide @number@ and cholecystokinin ) are modulators of memory.
Similarly , preincubation with the hydroxyl radical scavenger dimethyl sulfoxide ( DMSO ) resulted in the enhanced presence of DMT1 at the apical membrane.
Similarly , pretreatment of cultured ECs with serum containing Adipo attenuated phospholipase C-mediated Tcad cleavage.
Similarly , proangiogenic cell therapy has so far not maintained the original promises.
Similarly , relearning sessions showed only statistical trends between the groups ( F = @number@ p = @number@ ) .
Similarly , reproduction of Caenorhabditis elegans ceases in mid-adulthood.
Similarly , research to determine whether carotenoids consumed as supplements have similar benefits to increased dietary intake through whole foods , is still required.
Similarly , retarded secretion of proteo-hormones in hypothalamic neurosecretory neurons leads to hypothalamus induced combined pituitary hormone deficiency.
Similarly , rutaecarpine or CGRP I over-expression also inhibited Ang II-induced EPCs senescence.
Similarly scientists do not have atomic data to show how the compounds that reduce both fibril formation and toxicity in cells bind to Aβ42 oligomers.
Similarly , SIRT7 was decreased in lung tissues of bleomycin-challenged mice.
Similarly , Spearman correlation coefficients ( r CONCLUSIONS : Metabolomic measurements appear reproducible and stable in fecal samples collected with @percent@ ethanol or FOBT.
Similarly , studies in animal models show that physical activity has positive physiological and cognitive effects that correlate with changes in transcriptional profiles.
Similarly , surgical menopause in humans is rarely directly amenable to experimental research.
Similarly , SynCav1-transfected differentiated human neurons derived from induced pluripotent stem cells ( hiPSCs ) exhibited increased expression of DISC1 and markers of synaptic plasticity.
Similarly , systemic arterial hypertension , cardiovascular diseases and metabolic disorders should alert us to the possibility of obstructive sleep apnea syndrome.
Similarly , the agreement between the two visual methods was very high , and the agreement between each visual methods and RAI was substantial.
Similarly , the altered glycolytic pathway , the so-called ' Warburg effect' , rewires tumor cell metabolism to support the biosynthetic requirements of uncontrolled proliferation.
Similarly , the amplitude of the BOLD response was stable across age.
Similarly , the antioxidant activities might exhibit differential intracellular distribution rendering subcellular structures differentially vulnerable to toxic insults.
Similarly , the changes in dermal thickness obtained with the two treatments were not significant ( P = @number@ Mann-Whitney test ) .
Similarly , the higher CMV titers were found in elderly with worse functional status.
Similarly , the manner in which global and regional differences in white matter integrity contribute to age-related differences in cognition has not been well established.
Similarly the plaques from elderly patients show more calcification as compared with those from younger patients.
Similarly the prevalence of OI was @percent@ in frail and @percent@ in robust participants.
Similarly , the proportion of geriatric problems ( cognitive , malnutrition , depression and falls ) did not differ between these two groups.
Similarly , there are no data regarding the actual safety profile of the new-generation antihistamines at higher doses than those recommended in elderly patients.
Similarly , there was a significant association between plasma resistin and blood urea with growing older in diabetic patients.
Similarly , there was no clear association between performance on the DSST and BLL after accounting for all covariates.
Similarly , there was no influence of envelope colour on the number of participants returning their questionnaires ( OR @number@ @percent@ CI @number@.60-1.63 ) .
Similarly , there were no observed differences in risk of AD by regular use of either folate or B6 supplements.
Similarly , the secretory phenotype can promote wound healing by transiently providing growth factors and the initial inflammatory stimulus that is required for tissue repair.
Similarly , these phenomena were also observed in cultured mouse RTECs following AGE treatment.
Similarly , the sex and age of the juvenile faces did not appear to affect the accuracy of age estimation.
Similarly , the SUAs inhibited SR-BI-mediated cholesterol efflux from transfected BHK-21 cells.
Similarly , the δ-tocopherol concentration correlated positively with γ-tocopherol , α-tocopherol , lutein , Q10 , δ-CEHC , and γ-CEHC concentrations , respectively.
Similarly , this immobilisation model had no impact on the assessed blood flow characteristics.
Similarly , those reporting four to seven facilitators had lower odds for restricted life-space compared with those reporting three or fewer facilitators.
Similarly , three postulates are formulated here to help evaluate hypothetical proposals attempting to explain the pathogenesis of Alzheimer's disease ( AD ) .
Similarly , transient knockdown of Foxo1 at the wound site by local delivery of antisense oligodeoxynucleotides enhanced skin wound healing.
Similarly , using grip strength alone , the frailty status was classified correctly with mean classification accuracy of @percent@.
Similarly , variants associated with later age at first birth are associated with a longer maternal life span ( P~1.4 × 10-3 ) .
Similarly , we know little about what personal and household assistance is needed by people with chronic illness.
Similarly , well-developed muscle spindles in young biceps reflect early need of reflex control in learning and performing arm motor behavior.
Similarly , white matter disruption was associated with worse cognitive scores up to @number@ months later.
Similarly , with each @number@ mIU / L increase in TSH , the LDL-C level tended to show gradually greater increases as age increased.
Similarly , XFE progeroid syndrome results from defects in the ERCC1-XPF DNA repair endonuclease.
Similarly , younger adults ' age-stereotype reliance was larger when source memory was impaired in Experiment @number@
Similar measurements were made in Npc2 ( - / - ) mice at 70days.
Similar measurements were taken on the left side [ @number@ ( ± @number@ ) cm and @number@ ( ± @number@ ) cm ] .
Similar metabolic and histologic changes were evident in the lungs of the Npc2 ( - / - ) mice.
Similar models were constructed to test the effect of hypertension on WMH and lifelong cognitive change.
Similar nonsignificant trends were also seen with the use of hydrophilic or lipophilic statins.
Similar observations were made in the fibroblasts isolated from aged mice hearts.
Similar observations were obtained versus the healthy elderly men ( P < @number@ ) .
Similar or increased UTS was observed after oil storage.
Similar patterns but greater RRRs were observed for men with WC ≥ @number@ cm , notably @number@.4-fold greater in least active men who smoked.
Similar patterns of FOXO expression in normal joints and changes in aging and OA were observed in mouse models.
Similar patterns or trends were observed when saturated fat and carbohydrate were dichotomized into high and low as individual macronutrients.
Similar patterns were also evident for mild pre-eclampsia , although attenuated.
Similar patterns were apparent in the more detailed LMSChartmakerPro percentiles.
Similar patterns were seen for FVC and among never smokers.
Similar phenomena are found in multicellular eukaryotes by seemingly different mechanisms.
Similar plastic effects have been measured in cortically-generated auditory potentials but it is unclear how the two interact.
Similar polygenic AF susceptibility exists between Europeans and Japanese.
Similar proportions of drivers with cognitive or visual impairments were found regardless of ABT status.
Similar proportions of men and women were sexually active ( @percent@ and @percent@ , respectively ; p = @number@ ) .
Similar protection of salidroside against replicative senescence was observed as well.
Similar protective effects were observed in Tg mAPP mice overexpressing neuronal ABAD decoy peptide ( Tg mAPP / mito-ABAD ) .
Similar rates of amplification were obtained with the two techniques.
Similar rates of successful in-hospital procedures and deaths were observed in men and women.
Similar relationship is not observed between high-frequency hearing and cognition.
Similar relationships persisted for disabled participant.
Similar relationships were observed between clusterin and HV , although the relationship was stronger for left-side HV than the right-side.
Similar reliability in hippocampal activation was observed across both CDR groups overall , but the CDR @number@ group was more variable in left hippocampal activity.
Similar results are obtained analyzing the effect of immunosuppressive drugs.
Similar results following treatment with expanded mesenchymal stem cells were observed.
Similar results have been reported in GWAS of general cognitive ability.
Similar results were achieved by ISH.
Similar results were also obtained with normal B cells , where MEK1 inhibitor downregulated TβRII and subsequent TGF-β signaling.
Similar results were found after adjustment for age and gender.
Similar results were found after adjustment for limb length and body height.
Similar results were found for bioavailable-E2.
Similar results were found for FSH.
Similar results were found for FT4.
Similar results were found for total testosterone although not significant.
Similar results were found for VAT score as outcome measure although these results were only borderline statistically significant ( p≤0.10 ) .
Similar results were found in a randomized controlled trial on blood pressure management in acute ICH.
Similar results were found in case-control studies ( NC OR @number@ @percent@ CI @number@.47-2.36 ; posterior subcapsular cataract OR @number@ @percent@ CI @number@.97-2.65 ) .
Similar results were found in unadjusted analyses.
Similar results were found using conditional logistic regression models with propensity methods.
Similar results were found with SASP from SIPS-WI-38 on the MCF-7 proliferation.
Similar results were generally obtained in older patients with HbA1c ≤6.5 %.
Similar results were noted when analysis was performed separately for subjects whose involvement was unilateral or bilateral.
Similar results were observed for processing accuracy , although the age effect in this component was marginal.
Similar results were observed for stage- and age-specific analyses , with survival being consistently higher for nHW and API compared to other groups.
Similar results were observed in effect modification by Taq1.
Similar results were observed in mice immunized with hen egg lysozyme and aluminum adjuvant alone or together with treatment with T3.
Similar results were obtained both for the intermediate and nonclassical subsets and in vitro.
Similar results were obtained for exposure to anesthesia after the age of @number@ years and during @number@ @number@ and @number@ years before the first visit.
Similar results were obtained for the association of crisis reported following maternal parental death ( CFPD-M ) at different age groups and dementia.
Similar results were obtained for vectors treated with the anticancer drug , cisplatin.
Similar results were obtained in a longitudinal mixed-model regression analysis across the @number@ days of the week.
Similar results were obtained in human granulosa-like KGN cells treated with hydrogen peroxide ( H ( @number@ ) O ( @number@ ) ) .
Similar results were obtained in human subcutaneous ( hsc ) pre-adipocytes cultured in an age-adapted hormone mix with reduced levels of insulin and dexamethasone.
Similar results were obtained when performing in-depth cultures.
Similar results were obtained when prediabetes was used as the dependent variable.
Similar results were obtained when tertiles of walnut consumption were examined in trend analyses.
Similar results were obtained with grip strength and walking speed.
Similar results were reported by investigators.
Similar results were seen in all ages and both genders.
Similar results were seen using the FI after categorisation into ' high' , ' medium ' and ' low ' levels of frailty.
Similar risks were observed for cardiovascular mortality.
Similar sensitivities and specificities were observed for a decline over time greater than @number@ percentile zone from the first measurement.
Similar significant association was demonstrated between subjective cognitive difficulties and daytime sleepiness ( OR = @number@ p = @number@ ) .
Similar studies have also shown cognitive advantages amongst yoga practitioners versus non-practitioners.
Similar suspensions of Ibuprofen containing either sodium carboxymethylcellulose ( Na-CMC ) or ( HPMC ) were also produced.
Similar tendencies were observed for the associations of breast-feeding exclusivity with change in length , weight and BMI.
Similar to cartilage in adults , cartilage in children gets progressively thinner during skeletal maturation.
Similar to cerebral amyloid angiopathy patients , microbleeds in the general population cluster and the distribution is affected by APOE genotype.
Similar to children with a congenital SFK , uni-x sheep demonstrate a progressive increase in arterial pressure and a loss of renal function with aging.
Similar to estradiol-17β ( E2 ) , BPA increased stem-progenitor cell self-renewal and expression of stem-related genes in a dose-dependent manner.
Similar to growth curves used in pediatrics , cognitive charts allow longitudinal cognitive evaluation and enable prompt initiation of investigation and treatment when appropriate.
Similar to humans , it features consolidated nighttime sleep and advanced cardiovascular , neuroendocrine , and cognitive responses.
Similar to in vitro results , we observed downregulation of FAK , VEGF and Akt molecules to inhibit angiogenesis in the hUCBSC-treated nude mice brains.
Similar to Lyme disease transmitted by Borrelia burgdorferi , B. microti is spread by Ixodes scapularis ticks.
Similar to memTreg cells , the @number@ Teff subsets resided primarily in the memory CD4 + T cell compartment.
Similar to neuron-enriched gray matter areas , WM undergoes a series of changes during the process of aging.
Similar to other epithelial cells , taste cells turn over continuously , with an average life span of about 8-12 days.
Similar to other yeasts , the human pathogen Candida glabrata ages when it undergoes asymmetric , finite cell divisions , which determines its replicative lifespan.
Similar to oxygen , iron is essential for aerobic life and energy production.
Similar to PINK1 and parkin , DJ-1 also limits mitochondrial fragmentation in response to the mitochondrial toxin rotenone.
Similar to previous findings , HYPO was associated with slower V ( O₂p ) and LBF kinetics compared with CON.
Similar to screen-based studies , during free viewing in the real world low-level saliency was related to gaze direction.
Similar to that , inhibition of selective lipid transport of the SR-BI scavenger receptor resulted mainly in reduction of αTP and not αT uptake.
Similar to the endoscope for clinical use , a deep crack was found in the surface of the AA sample.
Similar to the entire organism , skin is subject to an unpreventable intrinsic ageing process.
Similar to the pathogenesis of transmissible prion diseases , amyloid fibrils induce a seeding-nucleation process that may lead to development of AA amyloidosis.
Similar to WTs , odor-evoked sniffing was not impacted in APP mice up to @number@ mo.
Similar training can be implemented in other surgical residency programs.
Similar translocation of leptin was found in brains from Tg2576 and apoE4 mice.
Similar trends were observed for the spectral notch frequencies which ranged from @date@ @number@ kHz at P0-1 to @date@ @number@ kHz in adults.
Similar trends were observed in all individual healthcare component cost and use metrics.
Similar trends were observed in women.
Similar trends were seen for PK protein level in AD and VaD.
Similar trends were seen when education was used as a proxy for socioeconomic status.
Similar uncertainties are present regarding the definition of ' old ' in this context.
Similar volume of both products was injected at baseline and touch-up.
Simple and reproducible tools to assess frailty in elderly patients are clearly on demand.
Simple changes in urban built environments may facilitate the full participation of all persons in society.
Simple descriptive statistics were performed.
Simple hypertension wasn't significantly associated with disability.
Simple linear regression revealed that all of the included factors significantly influenced SBS.
Simple partial and complex seizures are common modes of clinical manifestation.
Simple preliminary in vitro screening assays can reduce the time and expense involved.
Simple prognostic indicators can inform health promotion and care planning , but evidence is limited by heterogeneity in measures of function.
Simple regression analysis showed a significant inverse correlation between patient age and the magnitude of aMPFA : the correlation coefficient was @number@
Simple regression analysis was performed to determine the relationship between the patient's age and the magnitude of aMPFA , aLDFA , aMPTA and aLDTA.
Simple rinse can prevent implantation infection significantly.
Simple unadjusted linear regression was used to test whether baseline measures changed at each follow-up time point.
Simple-virilizing boys ( P < @number@ ) and girls ( P < @number@ ) were diagnosed later than their salt-wasting counterparts.
Simplified measurement of macular pigment optical density ( MPOD ) is important because of the ocular health benefits that are attributed to these retinal carotenoids.
Simulation has been used widely for training and assessment in the aviation industry as well as in automobile driving exams.
Simulation performed at different values of radiation effect and heterogeneity variance.
Simulation results suggested a central role of CD8 ( + ) T cells for adequate viral clearance kinetics in young and aged mice.
Simulations are carried out to examine the performance of the proposed method.
Simulations are performed to evaluate the finite-sample performance of the proposed methods.
Simulations show that these patterns are plausible in model cohorts that in the aggregate resemble cohorts in the Human Mortality Database.
Simulation studies are performed to examine the performance of the combination method.
Simulations were performed in a hypothetical cohort of Medicare beneficiaries suffering from insomnia.
Simulations with ten type profiles predicted varied patterns of accessibility problems.
Simultanagnosia , an impairment in simultaneous object perception , has been attributed to deficits in visual attention and , specifically , to processing speed.
Simultaneous and lagged models were specified and estimated using structural equation modeling.
Simultaneous binding of MDC1 and RNF8 to the highly conserved WD40 scaffold domain of WRAP53β facilitates their interaction and accumulation of RNF8 at DSBs.
Simultaneous combination treatment would be anticipated to provide further improvement but has not previously studied.
Simultaneous , competing masker digit streams were simulated at locations 15° left and right of center.
Simultaneous frontal bilateral near-infrared spectroscopy ( NIRS ) was performed to assess VMR by cortical oxy- and deoxy-haemoglobin concentration changes.
Simultaneous loss of 53BP1 can rescue the HR defect of BRCA1-defective cells and restore cellular viability.
Simultaneously , active polyribosome is more associated with long noncoding RNAs ( lncRNAs ) .
Simultaneously , a decay of the average brain volume , especially in the frontal lobe accompanies the process of aging.
Simultaneously , BMD decreased in the placebo group , while remaining stable in the treatment group.
Simultaneously , BPL and ECG were acquired with a pulse oximeter placed on the earlobe and Eindhoven triangle setup , respectively.
Simultaneously , cardiovascular diseases increase with age and are associated with ED.
Simultaneously , epigenetic marks were redistributed across the phases of the cell cycle and the DNA damage response ( DDR ) machinery was activated.
Simultaneously , every organism undergoes accumulative ' wear and tear ' during its lifespan , which confounds the effects of the ageing process.
Simultaneously , golgin-84 and Golgi reassembly stacking protein @number@ @number@ important Golgi matrix proteins , were decreased in the brains of elder mice.
Simultaneously , projects should not be entirely subsidized , otherwise there are no incentives to scale-up the innovations.
Simultaneously , the findings convey deficits concerning knowledge about ageing and health.
Simultaneously , the global trend of an aging population has placed a greater burden on the healthcare system.
Simultaneously , the maximum plantar and forearm loads during walking with an FWW-AR were measured.
Simultaneously , these breakthroughs enhance our knowledge about this neurodegenerative disease and raise the question of whether the disorder is preventable or even treatable.
Simultaneously , these technologies are generating uncertainties of an unprecedented scale that laboratories , clinicians , and patients are required to address and manage.
Simultaneously , they have the highest prevalence of falls and nine times greater risk of injury due to a fall.
Simultaneously , this intervention depresses Gardos channel-modulated erythrocyte rheological functions.
Simultaneously , we measured the LAV using the 2D biplane Simpson's method.
Simultaneous measurement of BOLD signal during atDCS also showed \ "youth-like \ " processing in an elderly population.
Simultaneous performance of a postural and a concurrent task is rather unproblematic as long as the postural task is executed in an automatic way.
Simultaneous presence of CHF and COPD significantly increased the risk of death.
Simultaneous procedures included submental lipectomy , fat injection , laser skin resurfacing , blepharoplasty , endoscopic forehead lift , and chin / jowl augmentation.
Simultaneous surface and needle-detected electromyographic ( EMG ) signals were collected during voluntary contractions , and then analyzed using DQEMG.
Simultaneous treatment of patients with first generation antipsychotics and second generation antipsychotics induced a significant decrease in SOD activity in the younger group.
Simultaneous ultrasonography based measurements of Achilles-soleus myotendinous junction and Achilles-calcaneus osteotendinous junction displacement together with Achilles tendon force estimates yielded free Achilles tendon mechanical properties.
Sinapaldehyde , syringaldehyde , syringol , and syringylacetone all have bond dissociation energies that are lower than resveratrol and comparable to the flavonoid catechin.
SIN can also serve as a proinflammatory mediator to regulate the MSC immunosuppressive effects.
Since absolute values depend on imaging methods and magnetic field strengths , continuous evaluation of specific reference values remains requisite.
Since AF is a disease of the aging heart , it is important to assess safety and efficacy of these new anticoagulants in elderly patients.
Since aging accompanies increased cellular senescence and death , we aimed to characterize potential age-related alterations in cf-DNA.
Since aging is a risk factor for OSA development , it is expected that its prevalence will increase with the current increase in life span.
Since all antihypertensive agents can lower blood pressure in the elderly , therapy should be based on its potential side effects and drug interactions.
Since all assembly types impact cell physiology , their localization and dynamics need to be tightly regulated.
Since Alzheimer's disease and a part of frontotemporal lober degeneration ( FTLD-tau ) have abnormal tau pathology in brain , these are called Tauopathy.
Since Alzheimer's disease was first described in @number@ many attempts have been made to reveal its main cause.
Since Ang II is a pleiotropic peptide , the age-protecting effects of RAS blockade are expected to involve a variety of other mechanisms.
Since auditory attention continues to develop throughout childhood , the present study explored whether attentional control of medial-efferent inhibition in 5-10 year-old children is adult-like.
Since cattle are the primary reservoir for STEC , lowering the prevalence of this pathogen in farm animals may reduce STEC outbreaks in humans.
Since CNR is correlated with age , subjects in Group2 and Group3 are more likely to have fluid overload.
Since data are scarce , the goal of this study was to gain new knowledge about acute lung function changes in children while SCUBA diving.
Since @date@ young people have been increasingly attracted to rescue roles.
Since diabetic hyperglycaemia causes hyperosmolarity , we investigated the contribution of hyperosmolarity in the proinflammatory endothelial effects of hyperglycemia , and investigated the mechanisms involved.
Since dietary interventions can alter neurodegenerative processes , Csb ( m / m ) mice were given a high-fat , caloric-restricted , or resveratrol-supplemented diet.
Since DS symptoms include premature aging , the shortening of telomeres might be one of the markers of cellular aging.
Since DXA is not appropriate for assessing tissue variability cautious clinical interpretation is warranted.
Since dysregulation of the EGF receptor has been associated with carcinogenesis , we examined AM251 regulation of EGF receptor ( EGFR ) expression and function.
Since established overweight at age @number@ already predicts BMI scores at age @number@ longitudinally , obesity interventions should be implemented in early childhood.
Since falls are a major public health problem in an aging society , there is considerable demand for low-cost fall detection systems.
Since fertility declines with age , it is not surprising that larger numbers of women over @number@ are seeking IVF.
Since fronto-limbic dysfunctions also underlie major psychiatric diseases beginning in adolescence , this investigation focuses on network characteristics separating adolescents from adults.
Since GGT activity correlated with GGT1 expression in serum exosomes isolated by differential centrifugation , we measured serum exosomal GGT activity in patients.
Since GP-LR models are Bayesian , computationally expensive cross-validation hyper-parameter grid-search methods can be avoided.
Since in most instances ubiquitination is the primary event in target selection , the system ofubiquitination and deubiquitination might be of similar importance.
Since it is the main relational and socialization region of each individual , it presents unique ways of suspension.
Since its activity is rather low in tumor cells it can be exploited as a source for therapeutic targeting.
Since its conception in the late 1990s , chemical biology has provided powerful and diverse small molecule tools for modulating stem cell function.
Since its creation in @number@ this mouse strain has been used by our laboratory and others for numerous studies ranging from growth to aging.
Since its discovery over two decades ago , the importance of this pathway in cell proteostasis has been made increasingly apparent.
Since its first description over @number@ years ago , cellular senescence has gained increasing attention.
Since its inception in @number@ the program has affected not only the fellows who participate , but also the field of health and aging policy.
Since its introduction , the TRAP assay has been widely used in cancer and aging studies.
Since lifetime abstainers and ex-drinkers have significantly different characteristics , researchers should distinguish between these groups.
Since mastocytosis is , by definition , a mast cell mediated disease ; these cells could be involved in this phenomenon.
Since mitochondria harbor their own genome , which encodes essential enzymes , mitochondrial protein synthesis is a determinant of metabolic adaptation.
Since more patients are seeking definitive management for their prolapse , the number of elderly patients undergoing sacral colpopexies will likely increase.
Since most drugs specifically act on their specific targets , H2 seems to differ from conventional pharmaceutical drugs.
Since mtDNA codes for subunits of respiratory chain enzymes , its lesions can alter homeostasis of the cell resulting in a decrease of intracellular ATP.
Since normal cells also secrete exosomes , isolation of cancer-derived exosomes from blood is a prerequisite for their better understanding.
Since no significant tipping was detected , the type of movement can be described as bodily movement.
Since @number@ ageing populations worldwide have received increasing attention by global policy-makers.
Since @number@ EU and EEA countries have shown decreasing seropositivity ; however , considerable regional variability exists.
Since @number@ however , mean sleep duration and the percentage of adults sleeping ≤ @number@ h have changed little.
Since @number@ less itinerancy and disturbance in the forest has occurred because the colonial administrations concentrated people and villages along the primary communication axes.
Since @number@ more than @number@ lung consultant physicians have been registered to specifically assess donor lungs and provide advice on intensive respiratory care to donors.
Since @number@ no one has exceeded Jeanne Calment's record of @number@ years , despite an exponential increase of centenarians.
Since @number@ participants were interviewed in the autumn of @number@ and the winter of 2013 / 2014.
Since @number@ people with active transfers either maintained strength or experienced decreased strength of @percent@ to @percent@.
Since @number@ prolonged 30-day cardiac monitoring has been recommended as a part of transient ischemic attack and stroke workup in patients with cryptogenic stroke.
Since @number@ there have been signs of improvement of the quality of drug prescribing to elderly persons in Sweden.
Since @number@ the United States has been in the midst of a profound demographic change : the rapid aging of the population.
Since @number@ the vaccine , ZOSTAVAX ( ® ) , has been licensed to prevent herpes zoster.
Since @number@ this trend has been stabilizing or turning into a downward trend.
Since @number@ we have been following up on the mental health conditions of four major aboriginal peoples of Taiwan.
Since only one randomized study has been published , publications , independent of evidence levels and quality assessment , were reviewed.
Since p53 has been identified as the most frequently altered gene in human cancers , regulation and stabilization of its normal functions are important.
Since paracrine action is the main action of MSCs , we examined the anti-inflammatory activity of each MSC under lipopolysaccharide ( LPS ) -induced inflammation.
Since people are unconsciously influenced by people around them ( i.e. by ' social norms' ) automatic processes could be used to promote PA.
Since protein damage can impair mitochondrial function , mitochondrial proteases are critically important for protein maintenance and elimination of oxidized protein.
Since proteins are the major functional building blocks of the biological world , most homeostasis regulations are realized at the protein level.
Since pterygia can form due to aging or UV exposure , it is reasonable to find D-β-Asp-containing proteins in specimens with pterygia.
Since R2 and R2 ' depend on the fiber orientation , their feasibility to estimate iron content in WM is challenging.
Since RCTs are expensive and challenging in rehabilitation , establishing feasibility prior to larger effectiveness trials is prudent.
Since recruitment of control mechanisms was less required , the frontoparietal network was less activated and performance was improved.
Since renal function diminishes with aging we examined the association between GFR and CAC in the Rotterdam Study , a population-based study of elderly individuals.
Since risk alleles are similarly present in middle and old age , environmental factors probably play similar role in these onsets of autoimmune diabetes.
Since self-renewal is largely studied by assays that measure proliferation , the concept of self-renewal programs imposed during non-proliferating conditions is counterintuitive.
Since several pathological conditions , including bacterial infections , display aberrant autophagy , we propose that pharmacological agents targeting this regulatory circuit hold therapeutic potential.
Since similar faces generate lower responses than dissimilar faces due to fMRI adaptation , this design objectively evaluates neural sensitivity to face identity across development.
Since smoking causes both herniation and cancer , data from indulgers will have to be analyzed separately from abstainers.
Since smoking rates vary across age and race / ethnicity groups , demographics alone could contribute to changes in smoking prevalence among the general population.
Since SRH is integrated in widely used psychometric instruments , further research is needed to establish the mechanism and implications of this finding.
Since technology acceptance factors fluctuate over time , a distinction was made between factors in the pre-implementation stage and factors in the post-implementation stage.
Since that time , however , the value of an evolutionary approach to medicine has become increasingly recognized.
Since that time , the ADC program has expanded to include @number@ centers in major medical schools throughout the United States.
Since the aging population increases demands on healthcare budgets , effectively stimulating physical activity ( PA ) against acceptable costs is of major relevance.
Since the beginning of mankind , man has sought ways to promote and preserve health as well as to prevent disease.
Since the biology of NTE is being explored , new pharmacological agents should be developed in future.
Since the cell-medicated immunity to VZV declines with aging , herpes zoster occurs more frequently in the elderly.
Since the compound affects the lifespan of yeast and flies it might be an anti-aging substance.
Since the discovery of the non-image-forming visual system , tremendous research efforts have been dedicated to understanding its mechanisms and functional roles.
Since the earliest descriptions of Alzheimer's disease ( AD ) , many theories have been advanced as to its cause.
Since the early 1980s , the field of skin rejuvenation has evolved rapidly.
Since the end of the Vietnam War and increasing tourism to Asia , there has been ongoing reverse migration of Westerners to Southeast Asia.
Since the era of highly active antiretroviral therapy , the prevalence and persistence of warty lesions in oral mucosa have increased.
Since the execution process lacks the nuclear and mitochondrial events in apoptosis , it has been referred to as quasi-apoptosis or eryptosis.
Since the family has a special place according to the Iranian culture and religion and the family health is a priority in their health.
Since the final decades of the last century , twin studies have made a remarkable contribution to the genetics of human complex traits and diseases.
Since the first report of a case in Saint Martin Island in @number@ it has spread to South , Central , and North America.
Since the first successful heart transplantation in @number@ significant improvements have been made regarding donor and recipient selection , surgical techniques , and postoperative care.
Since the initial release , we have enhanced this resource both in content and especially with regard to data mining support.
Since the introduction of combination antiretroviral therapy ( ART ) in @number@ the number of AIDS-related deaths has plateaued worldwide.
Since the introduction of Viagra in @number@ several case reports have linked Viagra to sudden sensorineural hearing loss.
Since their extraction from Clostridium botulinum , they have been harnessed and incorporated into different formulations with varied properties and actions.
Since their pharmacological manipulation in rodents has been reported to affect cognition , they are potential drug targets for AD therapy.
Since the late 1980s , the concept of ' successful ageing ' has set the frame for discourse about contemporary ageing research.
Since the latest refinements , lipostructure has revolutionised blepharoplasty and serving as a reference , it has become an established technique.
Since the level of total 25 ( OH ) D2 is low , only a minority of subjects had detectable 3-epi-25 ( OH ) D2.
Since the long term application of oral antibiotics is likely to be of limited efficacy this indicates the need for new antimicrobial solutions.
Since the measurement outcomes were not continuous , the data was analysed using non-parametric statistics.
Since then a generation , treated with special diet and medical foods right after neonatal diagnosis has reached adulthood.
Since then , a significant increase in weight and BMI was observed in both genders and across all specialty groups.
Since then at least @number@ members of this family have been identified in mammals.
Since then , data have become available on hip fracture incidence in the Ukraine.
Since then , four updates to the search were performed using the same search methods , and the most recent was @date@ .
Since then , it has been firmly established that telomere shortening imposes an individual fitness cost in a number of mammalian species , including humans.
Since then , more cases have been found , leading to great concern among patients and a dramatic decrease in bisphosphonate prescribing.
Since then , other studies have reported its applicability with reasonable methodology , although without a consistent scientific background and consensus.
Since then , there have been no studies of MS frequency in Hobart.
Since then , the use of BoNT in therapeutic and aesthetic indications has grown year-on-year , and continues to expand well beyond Scott's initial aim.
Since the population is aging , the prevalence of these conditions will probably increase considerably and require more resources.
Since the population is aging with a greater life expectancy , it is crucial that these questions be answered.
Since the prevalence of diabetes increases constantly , we attempt to address refreshment of criteria for screening of carotid artery disease in the diabetic population.
Since the previous review on this topic in @number@ the cohort of @number@ million baby boomers began turning @number@ in @date@ .
Since there are few treatments against oxidative stress , so it is important to search further therapeutic agents.
Since there are many reviews in this field , the focus was centered in articles published recently.
Since there is yet no cure for dementia , there is great pressure to discover potential therapeutics for these diseases.
Since the safety profile is pristine , an added advantage is the use of RSV as a dietary supplement.
Since these differences are quantitative , however , it was hypothesized that AD might simply reflect an accelerated aging process.
Since these post-translational modifications accumulate over a period of many years , they can only be studied using organisms that have lifespans measured in decades.
Since these values were obtained in the 1960s from subjects in a limited age range.
Since they arise developmentally , they are less likely to reflect environmental confounds.
Since this age group shows a rapid deterioration after onset , prompt decompression surgery is required.
Since this syndrome can resemble other diseases , its diagnosis is a significant challenge.
Since TRF2 inhibition leads to ATM activation , a novel positive feedback loop exists to amplify uncapped telomere-induced , p53-mediated cellular responses.
Since we found reduced BDNF-levels in subjects with a positive family history of Alzheimer's disease , we speculate that BDNF-reduction might precede cognitive impairment.
Since we found that the endolysosomal asparagine endopeptidase was responsible for truncation , we propose that it is a readout of microfusion in hypoxia.
Since women are more susceptible to obesity than men , it seems plausible that neural correlates may also be different.
Since women usually remain healthy through and beyond childbearing age , human communities include substantial proportions of economically productive postmenopausal women.
Since α1A is predominantly expressed in the prostate , higher selectivity for α1A may account for lower blood pressure-related adverse effects.
Singapore faces a rapidly aging population.
Singing also enhanced short-term and working memory and caregiver well-being , whereas music listening had a positive effect on QOL.
Single-agent chemotherapy would be a good choice for elderly lung cancer.
Single and multiple regression analysis was used for correlating BMD to weight and age.
Single- and paired-pulse stimulations of @number@ artifact-free MEG signal epochs were averaged separately.
Single and repeated doses of flupirtine-MR were very well tolerated.
Single ASCs are expanded in vitro into clonal organoid cultures to generate sufficient DNA for accurate whole-genome sequencing ( WGS ) analysis.
Single Bond @number@ adhesive was applied and the samples were restored with a composite.
Single Bond @number@ was applied to both sound and caries-affected substrates.
Single-cell transcriptomics on cultured live adult patient derived cells is a prime example of the promise of personalized precision medicine.
Single-centered patterns reflected more stable postural conditions and were more frequent with complete visual input and a wide base of support.
Single-channel electroencephalographic data were recorded from each subject using a vertical montage referenced to the right earlobe.
Single chronic inflammatory diseases are known to increase the risk of frailty.
Single-cohort HRs were pooled by random-effects meta-analysis.
Single daily sampling may not detect more frequent variability ( i.e. pulses ) in hormone levels.
Single disease occurred in @percent@ , dual disease in @percent@ and triple disease in @percent@.
Single joint fatigue affected torque variability at all lower extremity joints , with similar changes for both age groups.
Single-legged standing time and Timed-Up-and-Go tests characterized physical function.
Single-molecule analysis revealed that AUF1 slowed down assembly of AGO2-let-7b-mRNA complex unexpectedly.
Single nucleotide polymorphisms at the following loci were studied : COMT Val158Met , CYP1B1 4 Asn452Ser , CYP1B1 3 Leu432Val , and CYP3A4 1B.
Single nucleotide polymorphisms in ESR1 ( ER-α ) were also analyzed.
Single-nucleotide polymorphisms in the TMEM106B gene have been identified as a risk factor in frontotemporal dementia ( FTD ) .
Single nucleotide polymorphisms ( SNP ) associations with overall survival and recurrence-free survival were assessed using a Cox regression model.
Single nucleotide polymorphisms ( SNPs ) in the exons and their surroundings of the SIRT6 were studied using direct PCR sequencing.
Single nucleotide polymorphisms ( SNPs ) rs9534578 in GNG5P5 reached genome-wide significance after first replication phase ( p = 9.96×10 ( @number@ ) ) .
Single-organ comorbidity involving liver , lung , heart , or kidney before HCT has been traditionally found to cause organ toxicity after HCT.
Single photon emission computed tomography demonstrated left > right frontotemporal cortical abnormalities.
Single photon emission computed tomography ( SPECT ) images of pre-RT and post-RT were registered into RT dose distributions.
Single plain radiographs of both hands were taken.
Single-population studies are therefore an important complement to larger international collaborations.
Single standard deviation increase in genetic risk score is associated with @number@ d earlier age at onset.
Single-strand breaks are common DNA lesions and are associated with the neurodegenerative diseases , ataxia-oculomotor apraxia-1 and spinocerebellar ataxia with axonal neuropathy-1.
Single-strand breaks ( SSBs ) are the most common type of oxidative DNA damage and they are related to aging and many genetic diseases.
Single-stranded filaments laterally associate to form double-stranded , ribbonlike , and PHF-like filaments.
Single-tablet regimens are perceived to be less flexible in patients with multi-morbidity and at higher risk of drug-drug interaction.
Single tasks consisted of mental arithmetic cued by auditory tones , and a visuomotor task , drawing a circular shape with spatiotemporal constraints.
Single-task timing was comparable in both groups.
Single-voxel MRS was performed in the L5 vertebral body of @number@ subjects ( @number@ women and @number@ men ) .
SIPI takes non-hierarchical models , inheritance modes and mode coding direction into consideration.
SIPS-induced myoblasts exhibit large flattened cells and prominent intermediate filaments ( senescent-like morphology ) .
Sir2 / Sirt1 , a mediator of longevity in several animal models , is a member of the sirtuin family of type III histone deacetylases.
SIRT1-activating compounds ( STACs ) , which have been identified from a variety of chemical classes , provide health benefits in animal disease models.
SIRT1 agonist resveratrol was used to treat the doxorubicin-induced heart failure mouse model.
SIRT1 also reduced cell apoptosis by inhibition of p38MAPK phosphorylation and caspase-3 activation.
Sirt1 , a mammalian member of the sirtuin gene family , holds great potential for promoting longevity , preventing against disease and increasing cell survival.
SIRT1 and XRCC5 enable cells to cope with unfavorable growing conditions.
SIRT1 and XRCC5 were up-regulated after oxidant insult and expression levels increased in aging cells.
SIRT1 bound to the promoter regions of IL-8 and IL-6 , but dissociated from them during cellular senescence.
SIRT1 deacetylates FoxO1 and enables activation of FoxO1 transcription in multiple systems.
SIRT1 deficiency is subsequent to epigenetic silencing of its promoter.
Sirt1 enzyme activity assay was used to analyze enzymatic activity.
SIRT1 exerts protective effects against endothelial cells dysfunction , inflammation and atherosclerosis , indicating an important role on myocardial infarction ( MI ) pathogenesis.
Sirt1 expression is reduced during aging.
SIRT1 expression was barely detectable in the severely degenerated cartilage while SIRT1 was clearly expressed in the less damaged cartilage.
SIRT1 expression was examined using cartilage samples from patients undergoing total knee arthroplasty and femoral head replacement by immunohistochemistry.
SIRT1 forms a stable complex with DBC1 , an endogenous inhibitor.
SIRT1 gene expression was estimated to mediate @percent@ of the positive association between LTL and leukocyte mtDNA content.
SIRT1 has been implicated as a key factor in aging-related diseases.
SIRT1 has been shown to have a neuroprotective effect ; however , its working mechanisms are not well understood.
SIRT1 is also dispensable for life-span extension by spermidine.
SIRT1 is a member of the Sir2 family of NAD ( + ) -dependent protein deacetylases.
SIRT1 is a NAD-dependent deacetylase that participates in cellular controls of gene expression , metabolism , genomic stability and anti-aging.
SIRT1 is a NAD-dependent protein deacetylase possessing antiaging activities in a wide range of organisms.
SIRT1 is an NAD ( + ) -dependent protein deacetylase induced by metabolic stresses , such as nutrition or oxygen deprivation.
SIRT1 is involved in the pathogenesis of obesity , diabetes , and aging.
SIRT1 is proposed to mediate key aspects of CR , and small molecule activators may therefore act as CR mimetics.
SIRT1 level , a nicotinamide adenine dinucleotide-dependent deacetylase with anti-aging activities , is dramatically decreased in PT-ECFCs and correlated with gestational age.
SIRT1 limits apoptosis and inflammation by deacetylating p53 and p65 ( also known as RelA ) , a subunit of NF-κB.
SIRT1 / macroH2A1.1-dependent epigenetic regulation of lipid metabolism may be relevant to NAFLD development.
Sirt1 may also interfere with mechanisms implicated in pathological disorders.
SIRT1 might play important roles in the pathogenesis of OA.
SIRT1 might therefore be an important mediator of host-microbiome interactions.
SIRT1 overexpression also restores PT-ECFC capacity for neovessel formation in vivo.
SIRT1 over-expression reduced doxorubicin induced cardiomyocyte apoptosis with the attenuated ROS production.
Sirt1's activation patterns and roles in energy metabolism appear to have tissue specific differences.
Sirt1's activity in multiple tissues may decline with aging , and sustaining or reactivating this activity seems invariably beneficial.
Sirt1's activity on these substrates may underlie its connection with the metabolic changes brought about by caloric restriction ( CR ) .
SIRT1 silencing was found to induce cell growth arrest in HCC cells.
SIRT1 ( sirtuin-1 ) , an NAD + -dependent protein deacetylase , decreases ROS levels and participates in cell survival under oxidative stress conditions.
SIRT1 SNPs and serum-induced SIRT1 expression in older men may be more closely associated with nutrition and body composition than aging and age-related conditions.
SIRT1 was downregulated in a panel of non-small cell lung carcinoma ( NSCLC ) cells exposed to hypoxia for @number@ hours.
SIRT1 was over-expressed in cultured neonatal rat cardiomyocyte by adenovirus mediated gene transfer.
SIRT2 gene expression was also repressed by the Rho / SRF inhibitor , CCG-1423.
Sirt2 knockdown obtained opposing results.
SIRT3 expression is reduced in human breast cancers , and its loss correlates with the upregulation of HIF1α target genes.
SIRT3 loss increases reactive oxygen species production , leading to HIF1α stabilization.
SIRT5 has been shown to regulate the recently described post-translational modifications succinyl-lysine , malonyl-lysine , and glutaryl-lysine.
SIRT5 is a lysine desuccinylase known to regulate mitochondrial fatty acid oxidation and the urea cycle.
SIRT6 also undergoes auto-ribosylation , which might contribute to a self-regulation of catalytic functions.
SIRT6 belongs to the sirtuin family of protein lysine deacetylases , which regulate aging and genome stability.
SIRT6 deficiency is associated with various diseases including inflammation , cardiac hypertrophy , liver dysfunction , adipocyte / muscle disorders , and cancer.
SIRT6 expression in skin keratinocytes was increased by exposure to UVB light through activation of the AKT pathway.
Sirt6 expression levels were decreased in CRSwNP tissue.
Sirt6 expression levels were modulated by small interfering RNA transfection in human nasal epithelial cells ( HNE ) .
SIRT6 functions as an ADP-ribosylase and NAD ( + ) -dependent deacylase of both acetyl groups and long-chain fatty-acyl groups.
SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases.
SIRT6 is a key regulator of healthy ageing.
SIRT6 is an epigenetic modification enzyme that regulates gene transcription through its deacetylase activity.
SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in metabolism , genomic stability , and aging.
SIRT6 is one of the seven members of the NAD-dependent family of sirtuins mammals.
Sirt6 knock-out mice have been reported to develop typical features of aging and senescence at the age of 2-3 weeks and die within @number@ weeks.
SIRT6 may represent a novel target for developing future therapeutics for the treatment of aggressive NBs.
SIRT6-mediated ribosylation also enhances PARP1-dependent DNA repair under oxidative stress and aging.
SIRT6 promoted expression of COX-2 by repressing AMPK signaling , thereby increasing cell proliferation and survival in the skin epidermis.
SIRT6 recruits the chromatin remodeler SNF2H to DSBs and focally deacetylates histone H3K56.
SIRT7 belongs to the Sirtuin family of NAD-dependent enzymes , the members of which play diverse roles in aging , metabolism , and disease biology.
SIRT7 deficiency promotes breast cancer cell metastasis , while temporal expression of Sirt7 inhibits metastasis in polyomavirus middle T antigen breast cancer model.
SIRT7-deficient mice develop chronic hepatosteatosis resembling human fatty liver disease.
SIRT7 expression was reduced in aged HSCs , and SIRT7 up-regulation improved the regenerative capacity of aged HSCs.
SIRT7 has been shown to be important for ribosome biogenesis and transcriptional regulation.
SIRT7 knockout mice exhibit complications associated with fatty liver and increased aging in hematopoietic stem cells.
Sirtinol is a known inhibitor of sirtuin proteins , a family of deacetylases involved in the pathophysiology of aging.
Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.
Sirtinol significantly inhibited the activity of HNE from human neutrophils in response to various stimulators.
SIRTs are interesting drug targets as they are considered to be related to important pathologies such as inflammation and aging-associated diseases.
Sirtuin6 ( SIRT6 ) has been implicated as a key factor in aging and aging-related diseases.
Sirtuin enzymes regulate metabolism and aging processes through deacetylation of acetyl-lysines in target proteins.
Sirtuin genes and their downstream targets have been associated with lifespan in numerous organisms from nematodes to humans.
Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways.
Sirtuin @number@ over-expression or siRNA plasmid was transfected.
Sirtuin @number@ ( SirT1 ) is a deactylase that regulates substrates associated with stress mitigation , metabolism , and aging.
Sirtuin @number@ ( SIRT1 ) is a longevity gene that protects cells against oxidative and genotoxic stress.
Sirtuin @number@ was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease ( PD ) .
Sirtuins act either as accessory components or downstream factors of circadian oscillators , which are also under control by melatonin.
Sirtuins are a class of enzymes with important functions in regulation aging , metabolism , and genome stability.
Sirtuins are a conserved family of deacetylases whose activities are dependent on nicotinamide adenine dinucleotide ( NAD + ) .
Sirtuins are a group of molecules involved in longevity and stress resistance.
Sirtuins are associated with prolonged life span.
Sirtuins are considered attractive therapeutic targets for metabolic and aging-related diseases , such as metabolic syndrome and neurodegenerative disorders.
Sirtuins are evolutionarily conserved NAD ( + ) -dependent acetyl-lysine deacetylases that belong to class III type histone deacetylases.
Sirtuins are NAD ( + ) dependent deacylases enzymes.
Sirtuins are NAD ( + ) -dependent protein deacetylases that regulate metabolism and aging processes and are considered to be attractive therapeutic targets.
Sirtuins are nicotinamide adenine dinucleotide ( NAD + ) -dependent deacylases that have traditionally been linked with calorie restriction and aging in mammals.
Sirtuins are protein deacetylases regulating aging processes and various physiological functions.
Sirtuins are protein deacetylases that represent master regulators of senescence , metabolism , and substrate utilization.
Sirtuins are the mammalian homologs of the yeast histone deacetylase Sir2.
Sirtuins can also regulate metabolic pathways by changing preference for glycolysis under aerobic conditions as well as glutaminolysis.
Sirtuins , class III histone deacetylases , are proteins homologous to the yeast protein Sir2p.
Sirtuins comprise a family of deacetylase enzymes that catalyze the removal of an acetyl moiety from the ɛ-amino group of lysine residues within protein targets.
Sirtuins comprise a family of NAD⁺-dependent deacylases that are central to the body's response to diet and exercise.
Sirtuins exert their biological effects by catalyzing deacetylation and / or deacylation reactions in which Acyl groups are removed from lysine residues of specific proteins.
Sirtuins have gained considerable attention due to their impact as physiological targets for treating diseases associated with aging.
Sirtuins interact with metabolic pathways and may serve as entry points for drugs.
Sirtuin ( SIRT ) @number@ is a key protein in mediating the benefits of calorie restriction ( CR ) in mammals.
Sirtuins participate in the protection against these aging processes by promoting genome homeostasis in response to cellular stress.
Sirtuins regulate the aging process and are themselves regulated by diet and environmental stress.
Sirtuins regulate the cell cycle , DNA repair , cell survival , and apoptosis , thus having important roles in normal and cancer cells.
Sirtuins regulate various normal and abnormal cellular and metabolic processes , including tumorigenesis , neurodegeneration , and processes associated with type @number@ diabetes and obesity.
Sirtuins represent novel players in these complex regulatory circuits.
Sirtuins seem targeted by resveratrol to mediate its action on energy homeostasis.
Sirtuins share NAD dependency for their enzymatic activity , but some show NAD-dependent deacetylase activity , others exhibit ADP ribosyltransferase activity or both.
Sirtuins ( SIRTs ) are critical enzymes that govern genome regulation , metabolism , and aging.
Sirtuins ( SIRTs ) catalyze the NAD ( + ) -dependent deacetylation of N ( ε ) -acetyl lysines on various protein substrates.
Sirtuins such as SIRT1 are conserved protein NAD ( + ) -dependent deacylases and thus their function is intrinsically linked to cellular metabolism.
Sirtuins target a wide spectrum of molecules for diversified post-translational modifications , thereby exerting multiple physiological benefits.
SIS scores ≥2 were considered indicative of social isolation.
Site-matched differences in bone mass were compared among three generations.
Site-specific augmentation with fillers can now be used to refine facial shape and topography in a more predictable and precise fashion.
Site-specific muscle loss was defined as a ratio of MTH > @number@ standard deviations below the mean for young adults in each segment.
Sites with robust support for aging in place exhibited a statistically significant longer length of stay compared to sites with limited support.
Sitting on a stability ball or using sit-stand / standing desks does not impair task performance relative to the traditional seated condition.
Sitting time was determined by asking participants to indicate number of hours per day usually spent sitting.
Sitting time was self-reported at baseline , year @number@ and year @number@
Sit-to-stand is a fundamental activity of daily living , which becomes increasingly difficult with advancing age.
Sit-to-stand ( STS ) movements are essential for daily activities.
SITT were calculated from the first duodenal image to the first cecal image.
Situations such as the recovery from injury and illness can lead to enforced periods of muscle disuse or unloading.
Sivelestat is the only commercially available selective HNE inhibitor.
SI was defined : appendicular lean mass / squared height and calculated at every follow-up ( n = @number@ ) .
Six 1-hour PST-HC sessions included depression education , problem-solving skills , pleasurable activity scheduling , homework , and weekly telephone calls over a 6-week period.
Six acquisition media were compared to determine the most suitable media for RSSC collection.
Six additional loci with suggestive association evidence ( p < @number@ × 10 ( @number@ ) ) were also observed , including CACNA1D and WNT3.
Six aged persons have participated in this research.
Six and 8-year-old children were taught @number@ novel facts from two different sources and recall for fact and source information was later tested.
Six appropriately chosen dilutions were sufficient for good reliability ( @number@ ) in normosmic subjects.
Six aspects of photodamaged skin were recorded using a @number@ point scale at @number@ @number@ and @number@ months after the treatment.
Six broad categories emerged : Independence / Ability , Health , Mindset , Activity / Service , Family , and Spirituality.
Six cases of EBV-negative DLBCL ( @percent@ of NHL ) were present in the same series.
Six children presented with nodal disease , and @number@ presented with extranodal localization ( bone ) .
Six core tests from the Maastricht Aging Study were used to assess general cognitive impairment.
Six CPGs did not address loss or grief , and seven CPGs did not address or had minimal content regarding EOL care.
Six databases were searched.
Six dietary patterns were identified.
Six different ASPs were used to derive inter-scanner correction equations.
Six dimensions of PWB were included in the questionnaire.
Six doctors underwent a short training course on delirium.
Six FLSQ items demonstrated reliability and validity as stand-alone items outside their domains.
Six focus groups and two individual interviews were conducted.
Six healthy older adults voluntarily participated in this pilot study.
Six hours after light exposure , cell viability , necrosis and apoptosis were assessed using the Apotox-Glo Triplex™ assay.
Six-hundred and seven ( @percent@ ) were HIV-positive , with a mean duration of infection of @number@ ± @number@ years.
Six hundred seventy-three women were continent at baseline ; @number@ ( @percent@ ) developed UI symptoms at year @number@
Six hundred six ( @percent@ ) respondents believed that MOC should be tailored to accommodate the aging neurosurgeon.
Six main issues were encountered by researchers who participated in this survey.
Six measurements of the pharynx and two of larynx were performed.
Six-month assessments were available for @number@ participants.
Six-month dyadic skills and 9-month triadic competencies were positively related in preterm and full term infants.
Six-month follow-up was recorded in @percent@ of the patients.
Six-month mortality and decline in Barthel Index were defined as adverse clinical outcomes.
Six months 2DE and 2-year clinical follow-up were obtained.
Six months after chemotherapy initiation and at the one-year point , there were multiple , significant relationships among cytokines and multiple cognitive.
Six months after surgery , only @percent@ of patients continued to have sleep disturbance.
Six months later , @number@ of the original sample repeated the 26-item survey.
Six neurocognitive domains were assessed using tests designed to avoid ceiling effects.
Six neuroendocrine , metabolic , and anthropometric biomarkers were analyzed and values were transformed into an AL index using clinical reference cut-offs.
Six papers based on studies with particular epidemiological designs are presented here which have been selected on the basis of their visibility in the literature.
Six partial fixed dental prostheses had complications : @number@ debonded , @number@ had chipping , and @number@ had periapical pathology.
Six participants used the first prototype of RB ( RB1 ) and eight participants used the second prototype of RB ( RB2 ) .
Six patients had post-mortem brain analysis available for assessment of neuropathological findings associated with prion disease.
Six patients on Efavirenz switched their regimes , as this drug is known for its potential central nervous system ( CNS ) side effects.
Six patients ( @percent@ ) experienced adverse events , all tolerated.
Six patients were eligible for transfusion at home but only three of them could be treated at home.
Six patients with remaining rebuild-up in postoperative follow-up EEG showed poorer postoperative clinical outcomes.
Six ( @percent@ ) deaths were due to cancer , and four ( @percent@ ) were due to other reasons.
Six ( @percent@ ) did not receive any treatment.
Six per cent of men were current smokers and @percent@ were former smokers.
Six providers participated in a focus group to assess satisfaction with care.
Six regions of Poland were distinguished according to first level of Nomenclature of Units for Territorial Statistics ( NUTS ) classification .
Six residents voluntarily participated in 1-hour recorded interviews focusing on memory and guided by eight open-ended questions.
Six schools ( @percent@ ) included some palliative care content in related courses such as gerontology policy.
Six separate groups included surrogates ( n = 31 ) , aged ≥18 years , who made decisions for others.
Six Sigma and Lean Thinking are quality initiatives initially deployed in industry to improve operational efficiency leading to better quality and subsequent cost savings.
Six Sigma incorporated as part of the \ "company's or hospital's culture \ " would be most desirable but the learning curve will be steep.
Six SLCs cared for by a primary care geriatrics practice were intervention facilities , with the remaining @number@ being controls.
Six SLCs selected as intervention facilities , with the remaining SLCs serving as controls.
Six SNPs in PTH and @number@ SNPs each in PTH1R , PTH2R and PTHLH were analysed.
Six studies compared GLP-1 receptor agonists with short acting insulin as a treatment strategy to intensify basal insulin therapy.
Six studies demonstrated effective interventions , @number@ were inconclusive , and four were ineffective.
Six studies used cognitive intervention , improving memory and one study used physical activity as intervention , improving executive functions.
Six studies were included in this review.
Six studies were included in this review.
Six studies were selected for inclusion , whereas @number@ studies were excluded from the analytical review.
Six substitutions were described as putatively damaging by the bioinformatics tools and @number@ intronic variation was described to affect splicing.
Sixteen children were retested on the same tasks a year later.
Sixteen genes were identified by protein-altering variants in both East Asians and Europeans , and thus are likely to be functional genes.
Sixteen glass-infiltrated zirconia FPDs were used as a control.
Sixteen healthy , sex-matched individuals ( @number@ males , @number@ females , range 60-95 years ) were also recruited as controls.
Sixteen healthy young ( 22-28 years ; YF ) and @number@ healthy older ( 65-92 years ; OF ) females participated in the study.
Sixteen meta-analyses , representing @number@ pooled analyses , were included.
Sixteen of @number@ cases of polymorphic extranodal LPD were classified as EBV ( + ) mucocutaneous ulcer.
Sixteen older adults made a joystick movement under two conditions during functional magnetic resonance imaging.
Sixteen older ( @number@ ± @number@ yr ) overweight ( @number@ ± @number@ kg / m
Sixteen papers focusing on complementary treatment were also rejected.
Sixteen papers met the eligibility criteria and were included in the analysis.
Sixteen participants ( @percent@ ) received an on-road Fail score.
Sixteen participants were interviewed before and @number@ were interviewed after aging out.
Sixteen Penicillium species were identified , with P. commune ( @number@ strains ) and P. chrysogenum ( @number@ strains ) being the most abundant.
Sixteen ( @percent@ ) had benign paroxysmal positional vertigo , of which @number@ ( @percent@ ) had an additional peripheral vestibular impairment.
Sixteen per cent of 90-year old participants were ' free from OA'.
Sixteen ( @percent@ ) of fallers had injurious falls or fell more than or equal to two times.
Sixteen ( @percent@ ) of the original patients underwent revision surgery.
Sixteen resistance exercise trained women between the ages of 18-37 completed @number@ eccentric-biased extension exercises with their nondominant arm.
Sixteen studies were found to meet the inclusion criteria and assessed for quality using pre-specified criteria.
Sixteen studies with a total of @number@ participants contributed data to meta-analyses.
Sixteen volunteers ( age @number@.2±13.1 years ) underwent the oscillometric measurements and brachial ultrasound at rest and under nitroglycerin ( NTG ) administration.
Sixteen women had a monogamous relationship with a male spouse ; @number@ had a long-term female partner.
Sixteen women participated in a qualitative case study with semistructured interviews.
Sixteen young healthy male subjects were recruited for this study.
Six thousand nine hundred and eleven illiterate residents aged @number@ or older were investigated.
Six thousand , two hundred and fifty died.
Six to @number@ 24HR are required to properly rank individuals according to their usual vitamin K intake and limit attenuation of the regression coefficient.
Six training sessions were administered on alternate days over a 2-week period.
Six trials had adequate randomization , five had low risk of performance bias and four had low risk of detection bias.
Sixty-7 ( HC = @number@ , MCI = @number@ ) had Aβ scans available for analysis.
Sixty ADHD subjects were included into the study aging between @number@ and @number@ years.
Sixty age and gender matched healthy controls were chosen from a database of participants enrolled in the NIH EXAMINER multi-site study.
Sixty asymptomatic individuals were recruited to form five gender-balanced age groups between @number@ and @number@ years old.
Sixty cylindrical specimens ( @number@ × @number@ cm ) were prepared from each material and equally divided into three groups.
Sixty-day-old animals exhibited a performance deficit in all three tests.
Sixty-eight patients with MetS ( @percent@ ) and @number@ patients without MetS ( @percent@ ) had severe ED ( p = @number@ ) .
Sixty-eight physically inactive volunteers participated in exercise and TV-watching control conditions.
Sixty eight PwD and their carers were recruited through three community Memory Assessment Services.
Sixty-eight subjects were selected from the osteoarthritis initiative ( OAI ) control and incidence cohorts.
Sixty-eight women undergoing In vitro fertilization ( IVF ) treatment were enrolled in the study.
Sixty-five participants met criteria for frailty by the end of the study.
Sixty-five samples of scleral tissue were analyzed.
Sixty-four of the @number@ procedures encountered at least one complication.
Sixty-four patients ( @number@ in home oxygen alone and @number@ in home oxygen plus home NIV ) completed the 12-month study period.
Sixty-four percent also sought information from medical providers or social workers.
Sixty-four percent of facilities answered the questionnaire.
Sixty-four percent were African-American , @percent@ were single , and @percent@ were @number@ years of age or older.
Sixty healthy adults between the ages of 30-77 were included in this study designed to address this gap.
Sixty healthy subjects aged from the 20s to the 70s were recruited , and @number@ subjects were assigned to each age group.
Sixty older adults were assigned to an aerobic exercise , a coordination exercise , or a control group based on their previous exercise experience.
Sixty-one consecutive axillary lymph node dissections ( ALNDs ) were performed in @number@ patients who underwent surgery for stage II and III invasive breast cancer.
Sixty-one healthy men ( @number@ to @number@ yrs ) were enrolled in this study.
Sixty-one items on foodservice attributes , an overall satisfaction question , and demographic / contextual information were tested.
Sixty-one out of @number@ patients were older than @number@ @number@ underwent faecal diversion by TPI and @number@ by CLI.
Sixty-one patients with @number@ ambiguous pigmented facial macules and @number@ control photodamaged facial areas were included in the study.
Sixty-one percent of all participants stated that the elderly are needed in society.
Sixty-one percent of mild cognitive impairment participants progressed to dementia.
Sixty-one percent were women and the median age of all patients was @number@ years ( range , 0-102 ) .
Sixty overweight subjects were randomly assigned to consume either @number@ g / day of doenjang or placebo for @number@ weeks.
Sixty patients aged @number@ years and older will be recruited from primary care practices.
Sixty patient samples underwent Western blot analysis ( @number@ young , @number@ aged , and @number@ with AD ) .
Sixty percent could rise from a chair and @percent@ could walk independently.
Sixty ( @percent@ ) developed AKI within two months of anti-TB treatment , including @number@ ( @percent@ ) with a prior history of rifampin exposure.
Sixty ( @percent@ ) of @number@ organizations completed the survey.
Sixty percent of the female participants had muscle strength values below the cut-off and @percent@ had low SPPBm values.
Sixty percent of the reported stem cell studies involved transplantation , of which over three quarters were allogeneic transplants.
Sixty ( @percent@ ) participants developed new UI at discharge.
Sixty persons with severe dementia ( @number@ in the experimental and @number@ in the control group ) were enrolled.
Six types of DM have been identified : idiopathic , juvenile ( JDM ) , cancer-related other autoimmune diseases-related , iatrogenic DM and amyopathic DM.
Sixty-seven cyclists with a mean age of @number@ years ( SD = @number@ ) and extensive international experience participated in the study.
Sixty-seven ( @percent@ ) had at least two admissions during the study period ; the maximum number of readmissions was five.
Sixty-seven percent of establishments had voting procedures , and @percent@ declared that they assessed residents ' capacity to vote.
Sixty-seven percent of patients presented with their first event between the ages of @number@ and @number@ years , and @percent@ presented at ≤50 years.
Sixty-six patients with diabetes per health center were included.
Sixty-six studies were included.
Sixty six women ( @number@ per group ) , mean age of @number@ ± @number@ years , participated in the study.
Sixty subjects ( @number@ males , @number@ females ; mean age , @number@ years ; range , 20-78 years ) were recruited.
Sixty three emission lines have been identified in the spectrum that are dominated by calcium lines.
Sixty-three percent were tested in Spanish.
Sixty-two of the @number@ ( @percent@ ) patients who recovered from AKI had successful re-introduction or continuation of rifampin.
Sixty-two papers and four published scientific abstracts were selected for full review.
Sixty-two participants ( @percent@ ) fell during follow-up.
Sixty-two patients were ⩾65 years of age and @number@ were < 65 years of age.
Sixty-two subjects ( mean age @number@ years , standard deviation [ SD ] ± @number@ years ) with knee OA participated in the study.
Six-week-old mice were injected with the maximum tolerated dose of sildenafil citrate ( @number@ mg / kg / day ) or saline for @number@ days.
Six weeks of training improved blood lipids along with loss of visceral fat.
Six were elderly patients.
Six years later , at the age of @number@ a decline in their cognition was found.
Six young and @number@ older men were recruited , and muscle biopsies were taken from the vastus lateralis at basal state.
Size and aneurysm location , timing and type of treatment were analyzed.
Size effects or magnitude of associations across the different studies cannot also be determined.
Size exclusion chromatography of human serum demonstrated the presence of GGT activity and GGT1 subunits in fractions positive for CD9.
Sjögren syndrome is the prototypic disease associated with dryness of the eyes and mouth and predominantly affects women in their perimenopausal and postmenopausal years.
Skandinavisk Aktuarietidskrift 20 : , 150-199 ) .
Skeletal aging results in apoptosis of osteocytes , cells embedded in bone that control the generation / function of bone forming and resorbing cells.
Skeletal and cardiac muscle function are also decreased to mdx levels.
Skeletal fragility is common at metaphyseal regions of long bones.
Skeletal implants correct concave morphology by increasing projection and provide a means to resuspend cheek soft tissues that have descended off a deficient bony platform.
Skeletal injury is one of the most prevalent clinical problems that jeopardize the activities of daily life , especially in our aging society.
Skeletal malformations were associated with alterations in cartilage and a marked increase in trabecular bone mass.
Skeletal maturation was determined by physeal patency ( open ; or closed or closing ) on MRI.
Skeletal muscle abnormalities are responsible for significant disability in the elderly.
Skeletal muscle atrophy is a consequence of several physiological and pathophysiological conditions including muscle disuse , aging and diseases such as cancer and heart failure.
Skeletal muscle atrophy occurs during disuse and aging , or as a consequence of chronic diseases such as cancer and diabetes.
Skeletal muscle atrophy occurs in many chronic diseases and disuse conditions.
Skeletal muscle biopsies require transecting the muscle fibers resulting , in structural damage near the cut ends.
Skeletal muscle blood flow is attenuated in aged humans performing dynamic exercise , which is due , in part , to impaired local vasodilatory mechanisms.
Skeletal muscle-derived stem cells , called satellite cells , play essential roles in regeneration after muscle injury in adult skeletal muscle.
Skeletal muscle displays a strong structure-function relationship by which several architectural characteristics factor into its functional capacity.
Skeletal muscle dysfunction and mass loss is a characteristic feature in patients with chronic diseases including cancer and acute conditions such as critical illness.
Skeletal muscle energy metabolism has been a research focus of physiologists for more than a century.
Skeletal muscle exhibits remarkable plasticity with respect to its metabolic properties.
Skeletal muscle function is impaired in heart failure patients due , in part , to loss of myofibrillar protein content , in particular myosin.
Skeletal muscle generates superoxide and nitric oxide at rest and this generation is increased by contractile activity.
Skeletal muscle has an outstanding regenerative capacity that relies on its resident stem cells ( satellite cells ) .
Skeletal muscle homeostasis depends on muscle growth ( hypertrophy ) , atrophy and regeneration.
Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement , as well as nutrient and temperature regulation.
Skeletal muscle is a highly regenerative tissue , but muscle repair potential is increasingly compromised with advancing age.
Skeletal muscle is an integral body tissue playing key roles in strength , performance , physical function , and metabolic regulation.
Skeletal muscle is an organ system that , when challenged , is often injured in response to varying stimuli.
Skeletal muscle is endowed with a remarkable capacity for regeneration , primarily due to the reserve pool of muscle resident satellite cells.
Skeletal muscle is the largest organ in the body and contributes to innumerable aspects of organismal biology.
Skeletal muscle is the major storage site for glucose following a meal and as such has a key role in maintenance of blood glucose concentrations.
Skeletal muscle loss is an inevitable consequence of advancing age.
Skeletal muscle mass and other body composition factors were measured with octapolar bioimpedance InBody @number@ analyser.
Skeletal muscle mass declines and muscular strength also weakens with age.
Skeletal muscle mass decreased slightly , but significantly , in women.
Skeletal muscle mass , function , and repair capacity all progressively decline with aging , restricting mobility , voluntary function , and quality of life.
Skeletal muscle mass was estimated using bioimpedance analysis.
Skeletal muscle mass was estimated using the predicted equation from a bioelectrical impedance analysis measurement.
Skeletal muscle mass was measured using bioelectrical impedance , and muscle mass index was defined as muscle mass divided by height squared.
Skeletal muscle mitochondrial content varies extensively between human subjects.
Skeletal muscle mitochondrial oxidative capacity declines with age and negatively affects walking performance , but the mechanism for this association is not fully clear.
Skeletal muscle power starts declining after the age of @number@ with slight variations depending on the events.
Skeletal muscle provides a fundamental basis for human function , enabling locomotion and respiration.
Skeletal muscle regeneration efficiency declines with age for both men and women.
Skeletal muscle samples were obtained for gene expression using RNA-Seq analysis and to assess mitochondrial morphology.
Skeletal muscle samples were taken at baseline , @number@ h , @number@ h , and @number@ h postexercise from eight healthy , endurance-trained men.
Skeletal muscle showed type @number@ fiber-predominant atrophy with pale central clearing.
Skeletal muscle shows high plasticity in response to external demand.
Skeletal muscles in vertebrates have a phenomenal regenerative capacity.
Skeletal muscle ( SkM ) comprise ∼40% of human body weight.
Skeletal muscle specification and morphogenesis during early development are critical for normal physiology.
Skeletal muscle strength deteriorates in older age.
Skeletal muscle , the most abundant tissue in mammals , is essential for any activity in life.
Skeletal muscle undergoes numerous morphological changes from early adulthood to old age including muscle size , configuration , and structure.
Skeletal muscle wasting is a major reason for morbidity and mortality in many chronic disease states , disuse conditions and aging.
Skeletal myoblasts , adipose-derived stem cells , and bone marrow-derived mesenchymal stem cells ( MSCs ) have also been tested in clinical studies.
Skilled players outperformed less skilled and medium-aged players outperformed older-aged players in basketball and dart throws.
Skills assessments demonstrated mastery of most skills , but some providers required additional training.
Skill variety and coworker support were the most important job design variables for successful aging outcomes.
Skin AF ( arbitrary units ( AU ) ) was measured using the AGE Reader.
Skin ageing and gender influences on the scalp have been seldom studied.
Skin ageing is an irreversible process that is caused by both intrinsic and extrinsic factors.
Skin AGE levels measured in biopsy specimens are associated with the development and progression of diabetic microangiopathy.
Skin aging appears to be principally attributed to a decrease in type I collagen level and the regeneration ability of dermal fibroblasts.
Skin aging has received tremendous attention in recent years by both scientists and the lay public.
Skin aging is a complex phenomenon in which several mechanisms operate simultaneously.
Skin aging is an extremely important medical and social problem in the modern world.
Skin aging is an inevitable biological phenomenon of human life.
Skin aging is associated with changes in both the mechanical properties of the skin and extracellular matrix ( ECM ) components.
Skin aging is mainly due to intrinsic ( chronologic ) and extrinsic aging ( photo-aging ) .
Skin aging is the most apparent form of senescence and could reflect the aging of inner organs.
Skin aging is the result of internal and external factors.
Skin Aging manifests primarily with wrinkles , dyspigmentations , texture changes , and loss of elasticity.
Skin aging on the knee had the same tendency as the Crow's feet.
Skin aging-reducing strategies should incorporate the sex differences found in this study.
Skin also provides opportunities to interrogate the clock regulation of tissue metabolism in the context of stem cells and regeneration.
Skin appearance before and after application of Wild Plum compounds demonstrated an improved appearance of skin including a decreased number of wrinkles.
Skin autofluorescence and vessel stiffness were significantly linked to the AGE autofluorescence of the collagenase digestible collagen fraction from graft material.
Skin autofluorescence was measured with an autofluorescence reader ; pulse wave velocity with the VICORDER.
Skin biopsies from sun-protected inner arm were subjected to @number@'-end sequencing for expression quantification , with results verified by quantitative reverse transcriptase-polymerase chain reaction.
Skin biopsies revealed an increase in collagen in the dermis.
Skin biopsies were also taken from five subjects on day @number@
Skin biopsies were obtained before treatment , at the end of treatment , and at three months post-treatment.
Skin biopsies were performed in five volunteers before treatment and at @number@ months after the final treatment.
Skin biopsies were taken @number@ h after the last irradiation.
Skin cancer is the most common type of cancer in fair-skinned populations in many parts of the world.
Skin cancers are the most common cancers worldwide.
Skin changes have been described in myotonic dystrophy type @number@ ( DM1 ) .
Skin color is related to the distribution of skin chromophores and the structure of the dermis , which affects light scattering.
Skin-derived precursors ( SKPs ) are embryonic neural crest- or somite-derived multipotent progenitor cells with properties of dermal stem cells.
Skin elasticity was assessed at baseline and Months @number@ and @number@ using a cutometer.
Skin elasticity was significantly increased.
Skin examination is highly informative in these patients and reveals features suggestive of premature aging and impaired vitamin D homeostasis.
Skin examination was performed in @number@ DM1 , @number@ DM2 , and @number@ control , unselected patients by means of dermoscopy.
Skin explants were maintained ex vivo for @number@ days and massaged twice daily for one minute at various frequencies within the range of 65-85 Hz.
Skin friction coefficients on some body sites were higher in females than in age-matched males in some age groups.
Skin healing process is postnatally always associated with scarring of various extent.
Skin health is associated with the day-to-day activity of fibroblasts.
Skin images were graded according to the Beagley-Gibson system.
Skin is a self-renewing tissue that is required to go through extensive proliferation throughout the lifespan of an organism.
Skin is frequently exposed to a variety of environmental and chemical agents that accelerate ageing.
Skin is mainly damaged by genetic and environmental factors such as ultraviolet ( UV ) light and pollutants.
Skin is prone to the development of several diseases , varying from benign to malignant.
Skin is the outermost part of the body and is , thus , inevitably exposed to UV rays and environmental pollutants.
Skin is the single organ of vitamin D synthesis , induced by ultraviolet B light.
Skin laxity changes were evaluated objectively ( digital images , @number@ independent experts ) and subjectively ( patients ' satisfaction numerical rating ) .
Skin mechanical properties were assessed at the cheek , neck , volar forearm and dorsum of the hand using a non-invasive suction device.
Skin microrelief parameters were evaluated using the Visioscan ( ® ) VC98 - SELS @number@ from Courage + Khazaka.
Skin microtopography and stiffness affect the interaction of skin with contact surfaces contributing to PU development.
Skin microtopography and stiffness were measured at the PU predilection sites before and after loading.
Skin might present an accessible tissue for manipulation of telomerase activity and telomere length with the potential of ameliorating skin diseases associated with ageing.
Skin moisturizing effects were detected by mouse skin water content test.
Skin naturally changes with age , becoming more fragile.
Skin penetration experiments demonstrated efficient intraepidermal protein delivery particularly in barrier deficient skin , penetration of the nanogels themselves was not detected.
Skin photoageing is becoming one of the most studied cosmetological topics.
Skin photoaging , the most common skin damage , is caused by chronic UV irradiation.
Skin physiology measurements and immunoblotting were utilized as methodologies for validating toxicity.
Skin plays a protective role against the loss of water and external aggression , including mechanical stresses.
Skin problems generally were common , with over @percent@ of respondents reporting past problems.
Skin provides barrier protection for the body , but aging disrupts epidermal barrier function.
Skin quality was assessed via blinded live evaluation and subject satisfaction by questionnaire.
Skin rejuvenation has developed into one of the most popular indications for laser and intense pulsed light ( IPL ) treatment in dermatology.
Skin-related quality of life and patient satisfaction with skin appearance had significantly improved after the last treatment.
Skin replicas were analyzed using an optical profilometry technique.
Skin represents an attractive target for DNA vaccine delivery because of its natural richness in APCs , whose targeting may potentiate the effect of vaccination.
Skin represents an ideal model for the study of ageing.
Skin responses observed after treatment were moderate erythema , mild edema , itching , and desquamation.
Skin resurfacing and rejuvenation techniques have experienced significant advances in the last few decades , and new devices are continuously being introduced into the marketplace.
Skin resurfacing is very effective at improving aging symptoms , including wrinkles and skin imperfections.
Skin rigidity correlated with increasing length of time since menopause , however , only in the white subgroup.
Skin rigidity was assessed at the forehead and cheek using a durometer.
Skin samples were collected at @number@ and @number@ weeks after the treatment.
Skin samples were collected from the shaved area for histological examination by hematoxylin & eosin ( HE ) staining.
Skin sections from the cheek area were selected without eye region wrinkles or naso-labial lines for consumer interpretation.
Skin senescence is induced by various factors including intrinsic aging and extrinsic aging.
Skin-specific quality of life had significantly improved.
Skin specimens were obtained from the surgical margins.
Skin specimens were taken before and @number@ and @number@ months after treatment.
Skin surface lipid ( SSL ) film is a mixture of sebum and keratinocyte membrane lipids , protecting skin from environment.
Skin surface pH significantly increases with aging in the face.
Skin tears have been reported to have prevalence rates equal to , or greater than , those for pressure ulcers.
Skin Tester was used to analyze differences in facial skin parameters between patients affected by facial photoaging and healthy controls.
Skin texture is mainly determined by wrinkles , which arise from atrophy of the skin layers , elastosis , and facial expressions.
Skin thickening was observed in all patients studied , being more intense in the group of patients with photodamage ( p < @number@ ) .
Skin tightening was evaluated by morphometric analysis of collagen fibers and the dosage of collagen synthesis.
Skin tumors are sensitized by methyl aminomevulinate then illuminated with red light.
Skin uptake of osthole was 8-fold higher than that of coumarin.
Skin-wound healing is an orchestrated biological phenomena consisting of three sequential phases , inflammation , proliferation , and maturation.
Skin wrinkle and elasticity on the knee are age-dependent related and aging on the knee is highly related to Crow's feet.
Skin wrinkles and rigidity were correlated with age , time since menopause , weight , and body mass index ( BMI ) .
Skin wrinkles are associated with collagen synthesis and matrix metalloproteinase-1 ( MMP-1 ) activity.
Skin wrinkling , hair graying and lip height were significantly and independently associated with how old the women looked for their age.
Skin youthfulness was defined as the top @percent@ of individuals whose assessed skin aging features were most discrepant with their chronological ages.
Skipping breakfast is considered a frequent and unhealthy habit associated with an increased cardiovascular ( CV ) risk.
Skipping of exon @number@ of COL6A1 was found in @percent@ of index cases and was mostly associated with a severe clinical evolution.
Skull deformation is believed to be a contributing factor to some types of traumatic brain injury ( TBI ) .
SLC1A2 encodes excitatory amino acid transporter type @number@ ( EAAT2 ) , which clears glutamate from the synaptic cleft.
SLC25A24 encodes a mitochondrial inner membrane ATP-Mg / P Changes related to aging alone typically don't interfere with one's ability to function independently.
Sleep and arousals were scored according to AASM standards.
Sleep and metabolism are intertwined physiologically and behaviorally , but the neural systems underlying their coordination are still poorly understood.
Sleep and nap habits were assessed using a questionnaire.
Sleep and sleep quality data were collected for @number@ weeks using diaries and Actiwatches.
Sleep apnea has been recognized as a factor predisposing to atrial fibrillation recurrence and progression.
Sleep architecture was measured by polysomnography ( older adults = @number@ min ; young adults : @number@ min ) .
Sleep assessment / intervention in SCD might help prevent / delay AD onset.
Sleep consolidation is also associated with AD risk , and previous work suggests that APOE genotype and sleep may interact to influence cognitive function.
Sleep deprivation induced a significant increase in systolic and diastolic blood pressure in elderly but not young adults.
Sleep deprivation ( SD ) has becoming one of the most relevant health problem in modern societies.
Sleep deprivation ( SD ) leads to cardiovascular risk by disturbing autonomic nervous system ( ANS ) .
Sleep difficulties was assessed again at follow-up.
Sleep-disordered breathing is evident in both healthy aging and MCI with associated decrements in processing speed.
Sleep disorders and metabolic disease related to the circadian rhythm affect metabolic and endocrine activities via the autonomic nervous system and the intestinal bacterial flora.
Sleep disorders are a pervasive problem throughout all patient populations but represent an especially important health problem for the elderly.
Sleep disorders in midlife women should be treated because substantial improvements in quality of life and health outcomes are achievable.
Sleep disturbance and abnormal sleep-wake cycles are commonly reported in seriously ill older patients in the intensive care unit ( ICU ) .
Sleep disturbance is common in patients with dementia.
Sleep disturbances and cognitive impairment are common non-motor manifestations of Parkinson's disease ( PD ) .
Sleep disturbances are common among older women ; however , little is known about sleep experiences among chronic benzodiazepine users.
Sleep disturbances are common with dementia and can adversely affect waking function.
Sleep disturbances in Alzheimer's disease ( AD ) patients are associated with the severity of dementia and are often the primary reason for institutionalization.
Sleep disturbances increase with increasing age in both males and females and become fairly common in the older community when compared to their younger counterparts.
Sleep duration declined from an initial @number@ to @number@ h in @number@
Sleep duration , self-rated health , quality of life and other health-related variables were assessed using a self-report questionnaire.
Sleep duration was assessed by a self-report of hours of nightly sleep in the past month.
Sleep duration was assessed in a face-to-face interview and was self-reported.
Sleep duration was assessed in @number@ 2007 / 2008 , @number@ @number@ and @number@
Sleep duration was associated with both verbal and non-verbal memory , while sleep quality was only associated with verbal memory.
Sleep duration was calculated as the difference between each child's bed and wake times.
Sleep duration was categorized as < @number@ h , 7-8 h and > 8 h.
Sleep duration was not associated with proximal femur integral vBMD in the multivariate models.
Sleep duration was significantly correlated with age , depressive affect , interpersonal problems , and stress ; only age was a unique significant predictor.
Sleep duration was unrelated to cognition.
Sleep efficiency , as measured by the PSQI , component @number@ was also better with PRM ( P = 0.017 ) .
Sleep has been shown to foster the process of insight generation in young adults during problem solving activities.
Sleep increases variability equally and proportionally to daytime variability.
Sleepiness , short or long sleep duration and obstructive sleep apnea ( OSA ) are associated with insulin resistance ( IR ) .
Sleeping @number@ hours or less was not associated with higher mortality than sleeping @number@ hours in persons with good health status.
Sleep in older adults with Alzheimer's disease can often be extremely fragmented , thus disturbing normal sleep-wake rhythms.
Sleep is a fundamental physiological process , characterized by the activation of several cortical and subcortical neural networks.
Sleep is an active state that plays an important role in the consolidation of memory.
Sleep is a physiological process with an internal program of a number of well defined sleep stages and intermediate wakefulness periods.
Sleep is a restorative behavior essential for health.
Sleep is essential , but poses a risk to breathing in some children.
Sleep is implicated in cognitive functioning in young adults.
Sleep is necessary for the optimal consolidation of procedural learning , and in particular , for motor sequential skills.
Sleep loss results in higher stress vulnerability and is often found in mental disorders.
Sleep parameters were recorded by wrist actigraphy.
Sleep pattern changes are considered normal as individuals age.
Sleep problems are prevalent among older adults , often persist untreated , and are predictive of health detriments.
Sleep problems in children are very common and affect both the child and parents.
Sleep problems were measured by the Jenkins Sleep Questionnaire.
Sleep quality and duration were not related to children's task performance.
Sleep quality and poor emotional ( depression and anxiety tendencies ) were main related factors for blood deficiency syndrome ( P < 0.
Sleep quality declined over time but not for all women.
Sleep quality included quality classification and scores , sleep duration , sleep latency , and sleep efficiency.
Sleep quality markedly declines across the human lifespan.
Sleep quality was estimated by using the Sleep Scale from the Medical Outcomes Study.
Sleep quality was measured using The Pittsburgh Sleep Quality Index ( PSQI ) .
Sleep spindle activity was particularly impaired in PD patients who developed dementia , with a more posterior topographic pattern.
Sleep spindle peaks were identified for each individual and individual sigma band power was determined.
Sleep spindles are thalamocortical oscillations in nonrapid eye movement sleep , which play an important role in sleep-related neuroplasticity and offline information processing.
Sleep spindles have been associated with learning potential and intelligence ; however , the details of this relationship have not been fully clarified yet.
Sleep spindles promote the consolidation of motor skill memory in young adults.
Sleep state development in preterm neonates can provide crucial information regarding functional brain maturation and give insight into neurological well being.
Sleep undergoes predictable changes across the lifespan , with notably dramatic alterations occurring during adolescence and with old age.
Sleep was adequate and not associated with C-reactive protein.
Sleep was assessed in @number@ children via actigraphy and parent-report sleep diaries for @number@ consecutive days on @number@ separate occasions over @number@ months.
Sleep was assessed using actigraphy and diaries.
Sleep was polygraphically recorded during the last two nights , and blood samples were obtained at 15-min intervals for @number@ h.
Sleep was polysomnographically assessed and blood samples were repeatedly collected.
S' / L ' genotype was characterized by higher beta @number@ rhythm power in elderly compared with young women.
Slightly different patterns between male and female adults were found regarding the weight status associated with the fewest depressive symptoms.
Slightly elevated homocysteinemia may contribute to increasing TPx and reducing TAS in the OP group.
Slightly higher adverse event rates were observed with Fitzpatrick skin type IV for both compounds.
Slightly over half of respondents were women ( HRS : @number@ @percent@ ; ELSA : @number@ @percent@ ) .
Slingshot-1 ( SSH1 ) is a protein phosphatase that dephosphorylates and activates cofilin , an actin-severing and -disassembling protein.
Slingshot-1 ( SSH1 ) is a protein phosphatase that specifically dephosphorylates and activates cofilin , an F-actin-severing protein.
Sling training was more effective in that than traditional physiotherapy.
Slips and falls during ordinary daily activities are a common cause of fractured bones and muscle injury.
Slope and caudal radius of curvature decreased with age , and increasingly convex morphology was noted at most levels.
Slope and variability estimates were used to reconstruct \ "real-world \ " OCT imaging measurements with computer simulations.
Slope at L5 was steeper than other levels ( @number@.7°±10.5° , p < .0001 ) .
Slope , caudal morphology , and radius measures showed large interspecimen variation.
Slope eGFRs before and after entry into the LCC showed that @percent@ of patients improved on entry into the LCC.
Slope was significantly different from @number@ and indicated that there was modest change over time.
Slowed processing speed only predicted falls in the presence of slowed gait ( interaction ) .
Slower atrophy in middle frontal and angular gyri may predict late-life CRF.
Slower atrophy in middle frontal and angular gyri was associated with higher late-life CRF , independent of CRF at baseline magnetic resonance imaging.
Slower gait speed and lower knee ROM were correlates of knee pain and were found to mediate the association between age and oxygen consumption.
Slower LTL attrition rates were observed in ever smokers over 8years of follow-up.
Slowing down of Wrel in relation to the calendar age increment was found if the sum doses were lower than @number@ cSv.
Slowing of movement with aging is inevitable.
Slowing of response times due to distraction by irrelevant targets was larger in older than younger participants.
Slowing was strongly associated with self-reported fatigue and walking ability but weakly associated with performance-based mobility measures.
Slowly biodegradable or nonresorbable fillers may give rise to severe reactions that show little or no tendency to spontaneous improvement.
Slowness , although less known , has been also recently reported in children with ADHD and may contribute to their learning difficulties.
Slow response time and greater response time variability have been highlighted by several computerized tasks.
Slow walking speed is strongly associated with adverse health outcomes , including cognitive impairment , in the older population.
Slow waves become more numerous in stage N3.
Slow wave sleep ( SWS ) is known to favour episodic memory consolidation.
SLRs and meta-analyses ( MAs ) of observational studies investigating the association of psychological variables and PA were considered eligible.
SLRs and meta-analyses ( MAs ) of observational studies that investigated the behavioral determinants of PA were considered eligible.
SLT-VEGF is a recombinant cytotoxin comprised of Shiga-like toxin ( SLT ) subunit A fused to human vascular endothelial growth factor ( VEGF ) .
SMA-affected individuals harbor low SMN expression from one to six SMN2 copies , which is insufficient to functionally compensate for SMN1 loss.
Smac peptidomimetics , downregulation of XIAP or cytosolic expression of cleaved Smac restores apoptosis in PARL-deficient cells.
Small arteries from @number@ essential hypertensive patients ( HT ) and @number@ normotensive individuals ( NT ) were dissected after subcutaneous biopsy.
Small bore , atraumatic needles reduce the occurrence of post-lumbar puncture headache ( PLPH ) .
Small but significant associations were observed between attendance and memory in the MI-WP and general cognition in the LI-AP.
Small but significant improvements in IIEF scores over time also were noted with TRT.
Small but significant pre-treatment to post-treatment differences were found on the Harvard Trauma Questionnaire and a number of other ratings in both groups.
Small dense LDL ( sdLDL ) has been reported to be more atherogenic than large buoyant LDL ( lbLDL ) .
Smaller age differences in availability were also found for items stored inside the focus of attention.
Smaller amounts of abnormal tau were observed in neurons and rarely in oligodendrocytes.
Smaller fragments of the N-terminal region of RECQL4 did not rescue the cells from lethality.
Smaller frontal cortical thickness was also associated with better EM ( p < 0.01 ) and SDM ( p < 0.01 ) performance in OA.
Smaller frontal lobe volumes were observed as persistent group differences among women assigned to active HT compared with placebo.
Smaller hippocampal and total brain volumes and increased WMH load represent proxies for underlying vascular brain injury.
Smaller linear anisotropy partially mediated age-related reduction in speed of processing.
Smaller mouse strains , for example , tend to have lower plasma IGF-1 levels and to be longer-lived.
Smaller or no effects were observed for all other outcomes.
Smaller proximal cross-sections had thicker less porous cortices of higher MMD , a small medullary canal with little trabecular bone.
Smaller reductions were observed for SBMP , regardless of moisture conditions.
Smaller skin incisions ( transverse or longitudinal ) and the mapping of carotid artery bifurcation with Doppler ultrasound are promoted.
Smaller TICV increased the odds of dementia , Alzheimer's disease , and vascular dementia in participants with WMLs.
Small excretory ducts were arranged in groups , often surrounded by the clusters of lymphoid cells.
Small , frequently undetected , target location shifts invoke fast , automatic adjustments , usually without awareness.
Small group differences in education , cognitive status , and health suggest positive selection may have attenuated possible biases.
Small heat shock proteins ( sHSPs ) are gatekeepers of cellular homeostasis across species , preserving proteome integrity under stressful conditions.
Small increases in lateralization with age were seen , but no differences in gender were observed.
Small infarctions were seen in the subcortical white matter , the basal ganglia , the brainstem and the cerebellum.
Small interfering autophagy-related @number@ was used to evaluate the role of autophagy in mitochondrial dysfunction.
Small interfering RNA ( siRNA ) -mediated knockdown of ARFGAP3 showed that ARFGAP3 siRNA markedly reduced LNCaP cell growth.
Small interfering RNA targeting endothelial NO synthase reduced the antisenescence effects of insulin.
Small molecule inhibitors of BTK are being investigated for treatment of several hematologic cancers and autoimmune diseases.
Small molecule senolytic agents are being developed.
Small proportions of the direct effects were mediated by individual health behaviors.
Small quantities of tissue can be directly placed on some chemical matrices to stabilize DNA , however RNA and proteins are not preserved.
Small RCFs were more likely to be for profit than larger RCFs.
Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival.
Small scale randomized clinical trials ( RCTs ) of T supplementation suggest a protective effect against myocardial ischemia in men with coronary artery disease.
Small studies in humans have suggested that temperatures may be lower among elderly populations , usually attributed to loss of thermoregulation.
Small studies reported some benefits of testosterone treatment in combination with oestrogen on cognition , although these were of short duration.
Small to moderate reductions in resting and exercise blood pressure have been reported with some indication that this effect may be genotype dependent.
Small ubiquitin-related modifiers ( SUMOs ) are important regulator proteins.
Small vertebral size is an independent risk factor for osteoporotic vertebral fractures.
Small vessel diseases ( SVDs ) of the brain are likely to become increasingly common in tandem with the rise in the aging population.
SMAP2-deficient mice provide a model for globozoospermia in humans.
SMAP2 is an Arf GTPase-activating protein that is located and functions on early endosome membranes.
SMAP2 therefore belongs to an ArfGAP subtype that resides on the TGN and functions as a negative regulator of vesicle budding from the organelle.
Smart furniture may play a role in promoting the health and independence of diverse user groups.
Smart multifunctional materials can play a constructive role in addressing some very important aging-related issues.
SMC rises from @percent@ in the 65-69 age groups to @percent@ in the @number@ and above group.
SMCs were also associated with impaired delayed recall ( p = @number@ ) but this did not remain significant after statistical adjustment for multiple comparisons.
SMCs were inversely associated with conscientiousness ( p = @number@ ) and directly associated with neuroticism ( p < @number@ ) .
SMC were associated with a number of specific objective cognitive deficits including poor verbal fluency , and poor immediate and delayed recall.
SMC were obtained through questions regarding memory complaints.
SME , in a micelle form , strengthened the inflammatory response more than SME-loaded nanobubbles.
SMFE reduced Nε- ( carboxymethyl ) lysine ( CML ) expression , whereas SMFE stimulated fibrillin-1 expression compared to treatment with methyglyoxal.
SM gain was associated with increasing CD4 count , whereas stavudine use may contribute to SM loss.
Smilax glabra Roxb ( sarsaparilla ) has been used in folk medicine because of its many effects.
SMI participants were taught coping skills and uncertainty management strategies while LDE participants learned about liver function and how to stay healthy.
SMI was significantly associated with protein intake and statin treatment.
SMM index and SMM : FFM ratios were similar among the ethnic groups in women , excluding SMM : FFM ratio in Brazilian.
SMN1 encodes SMN , a ubiquitous housekeeping protein , which makes the primarily motor neuron-specific phenotype rather unexpected.
Smoke-free policies rather than modifying tobacco products should be enforced.
Smokers did not differ from nonsmokers for any of these parameters.
Smokers had a lower baseline inhibin B level relative to age at the FMP than nonsmokers ( P = @number@ ) .
Smokers without ND still have relatively high rates of dependency symptoms.
Smokers with SHS exposure at work ( @percent@ ) did not have significantly higher cotinine levels after adjustment.
Smokers with the TT genotype had the highest Hcy levels.
Smoking accounts for a large share of lung cancer.
Smoking and alcohol use should also be addressed.
Smoking and body mass index showed moderately inverse associations with MPOD at @number@.0° , and age was positively related to MPOD at both eccentricities.
Smoking and deprivation related to increasing comorbidity ( P < @number@ ) .
Smoking and drinking alcohol were inversely associated with vaccination.
Smoking and hypertension were mainly named.
Smoking and stress are risk factors for periodontitis that are common and shared between young , adult , and older age.
Smoking and sunbed use were associated more strongly with wrinkling in women than in men.
Smoking and the use of drugs of addiction have a negative impact on maternal and infant leukocyte TL , possibly through oxidative telomere damage.
Smoking-attributable kidney cancer deaths decreased while obesity-related deaths rose , most prominently in women from developing countries.
Smoking-attributable mortality was assessed using epidemiological models.
Smoking behavior had a strong impact on the health of men , whereas fruit and vegetable consumption was a relevant factor for women.
Smoking , body-mass index , and exercise patterns in midlife and late adulthood are predictors of subsequent disability.
Smoking can transiently modify the regulation of blood pressure ( BP ) by a swift effect on the autonomic nervous system.
Smoking causes endothelial dysfunction , increased oxidative stress , and decreased nitric oxide synthesis leading to inward remodeling.
Smoking cessation is effective regardless of patient age and length of consumption.
Smoking cessation may increase the efficacy of lower gastrointestinal endoscopy.
Smoking cessation programs might aim to increase network diversity so as to prevent relapse.
Smoking did not mediate and rarely moderated associations between MHD and smoking-related disease.
Smoking effects on LTL appear masked by HIV , and HCV infection may accelerate LTL shortening , particularly in coinfected individuals.
Smoking fully mediated the effects of both accumulated childhood misfortune and child maltreatment.
Smoking has reduced its impact in men but not yet in women.
Smoking history was categorized as never smoker , former smoker , and current smoker and cumulative pack years was calculated.
Smoking increases oxidative DNA modification and thus may influence telomere dynamics and human telomerase reverse transcriptase ( hTERT ) activity.
Smoking induced elevation both in Cd and in Pb in blood.
Smoking , initial weight and weight increase were significant factors.
Smoking intensity and pack-years of smoking were also inversely associated with LTL , and a positive association was observed with years since smoking cessation.
Smoking is a potential risk factor for age-related cognitive decline.
Smoking is associated with mood disorders , including depression and anxiety.
Smoking is the greatest risk factor for both chronic obstructive lung disease and interstitial lung disease.
Smoking is the risk factor most consistently associated with AMD.
Smoking , lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels.
Smoking negatively affected the adjusted levels of Se among seniors aged ≥65 years but this was not observed in other age groups.
Smoking or earlier CVDs greatly increase the risk for further cerebral and cardiovascular events in persons after @number@ years.
Smoking-related bladder cancer deaths increased among women from developed countries and decreased among men.
Smoking-related epigenetic biomarkers may open new avenues to better quantify the adverse health effects of smoking , and to better understanding of the underlying mechanisms.
Smoking-related probes at 2q37.1 and AHRR were stable-VMPs and related to time since quitting.
Smoking status was significantly and independently related to longevity ; @percent@ of the non-smokers survived to the age of @number@ and @percent@ of the smokers.
Smoking tobacco is a known risk factor for the development of colorectal cancer and for mortality associated with the disease.
Smoking was also an important risk factor for IS and HS ; risk was reduced by quitting.
Smoking was associated with an increased risk of hyperechoic parenchymal foci.
Smoking was found to increase the degree of wrinkling ; however , no differences related to ethnic origin in relation to smoking were observed.
Smoking was inversely associated with LTL.
Smooth muscle cell ( SMC ) proliferation is a hallmark of vascular injury and disease.
Smoothness , softness and roundness of stimuli positively correlated with luminance of the chosen colour ; and smoothness and softness also positively correlated with chroma.
Smooth test for goodness of fit.
SMP30 may be a potent inhibitory protein against oxidative stress and chronic inflammation.
SMRT ( mRID1 ) cells exhibit increased susceptibility to oxidative damage , which could be rescued by PPAR activation or antioxidant treatment.
SMs traveled seven times the distance to attend CMPs , highlighting the need for greater access to such sites.
Snack occasions were self-reported as distinct eating occasions.
SNAI2 expression in selected PCa cells , by regulating their self-renewal , NED and metastatic potential , endows them with highly malignant properties.
SNAI2 may thus constitute a key target for modern approaches to PCa progression.
Snail and fish mortality appeared to be higher in SRB microcosms than in Equus and AGLR microcosms.
Snail growth data followed the von Bertalanffy Model.
Snake venoms are natural sources of biologically active molecules that are able to act selectively and specifically on different cellular targets , modulating physiological functions.
SNCA-OVX mice display age-dependent loss of nigrostriatal dopamine neurons and motor impairments characteristic of Parkinson disease.
SND and AF frequently coexist.
Snellen acuity involves target recognition ; contrast acuity detects threshold differences ; both aspects can be important.
( Snellen equivalent 6 / 82 , range 6 / 900- @date@ ) .
SNF admission is strongly associated with PEG tube insertion during hospitalization and with nursing home factors.
S-Nitrosylated proteins in signaling networks modulate key events in brain development.
S-Nitrosylation disrupts MEF2-DNA binding and transcriptional activity , leading to impaired neurogenesis and survival in vitro and in vivo.
S-nitrosylation inhibits the activity of the protein deacetylase SIRT1.
S-Nitrosylation modulates neuronal development by reaction with specific proteins , including the transcription factor MEF2.
S-Nitrosylation of protein-disulfide isomerase may also be associated with mutant Cu / Zn superoxide dismutase toxicity in amyotrophic lateral sclerosis.
S-nitrosylation of the active site of PDI inhibits the PDI activity and links protein misfolding to neurodegenerative diseases like Alzheimer's and Parkinson's diseases.
SN occurrence , aging , and disk location were positively correlated with lumbar disk degeneration grade.
Snoring increased with aging.
Snoring , witnessed apnoea and nocturnal awakening were observed in @number@ @number@ and @percent@ of participants , respectively.
SNP responses were also similar.
SNP rs11263763 genotype was associated with HNF1B mRNA expression but not with HNF1B methylation in endometrial tumor samples from The Cancer Genome Atlas.
SNP rs144581330 in exon @number@ was also predicted to be probably damaging by PolyPhen2.
SNP rs535812 revealed a stronger association with obesity in meta-analysis of these two samples ( P = @number@ ) .
SNPs and both fitness groups were not associated with serum irisin levels.
SNPs associated with BUA or SOS in the Framingham study with p < 10-4 were selected and genotyped using SEQUENOM technology.
SNPs at ARNTL , TF , and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis.
SNPs in MARK4 were marginally associated with AD.
SNPs in miRNA-processing genes may modify associations between ambient pollution and sICAM-1 and sVCAM-1 , which are correlates of atherosclerosis and cardiovascular disease.
SNPs in the promoter region of the CETP gene is likely important in regulation of the expression of the CETP gene.
SNPs in these @number@ genes have a cumulative effect with PD.
SNPs located in the mutually exclusive splice region had opposite effects on the protein concentrations.
SNPs not directly genotyped were imputed based on @number@ Genomes.
SNP statistical analysis was performed using SNPstats.
SNPs that associated with fertility were analyzed for association with mortality.
SNPs within the gene ATP binding cassette A7 ( ABCA7 ) reached significance in these studies , warranting investigation into their actions.
SNPs with significant associations were then tested in the BEOCOPD study and the International COPD Genetics Network.
SNVs also increased with age with the highest rate of accumulation in the non-coding control region which contains elements necessary for translation and replication.
SNX27 associates with the γ-secretase complex subunit presenilin @number@ this interaction dissociates the γ-secretase complex , thus decreasing its proteolytic activity.
SNX27 deficiency results in reductions in ependymal cells and cilia density , as well as severe postnatal hydrocephalus.
SNX27 is a trafficking component required for normal brain function and was shown previously to suppress γ-secretase-dependent amyloid precursor protein and Notch cleavage.
SO4-2 seven day moving averages are associated with higher sICAM-1 and a suggestive association was observed with sVCAM-1 in aging men.
Sobel test revealed that IGF-1 was a significant partial mediator in the relationship between age and SOS ( z = @number@ ) .
So , BINS can be considered an instrument of adequate psychometric properties , able to screen children under risk , according to Psychological Association requests.
So-called photoaging has been identified as the major factor in skin aging.
Soc. Am.
Soc. Am.
Soccer is the most popular sport in the world.
Soccer players are at high risk for repetitive subconcussive head impact when heading the ball.
Soccer players demonstrated greater cortical thinning with increasing age compared to controls in the right inferolateral-parietal , temporal , and occipital cortex.
Social activities are beneficial for both gender groups , but more so for males than for females.
Social activities had no significant association.
Social activity was divided into various elements and the same analysis was conducted for each of these elements.
Social ageing is limited to the role of an old person is culturally conditioned and may change as customs change.
Social ageing refers to how a human being perceives the ageing process and how society sees it.
Social and cognitive aspects seem to be more important than physical health.
Social and emotional loneliness shared @time@ % variance.
Social and personal role factors were identified.
Social behavioral abnormalities are commonly seen in the later stages of dementia.
Social capital and participation predicted happiness across the age span.
Social capital inequalities in low SRH , physical inactivity , and hypertension were decomposed into demographic , socioeconomic , network and psychosocial determinants.
Social capital was assessed for all adults interviewed from 2002-2010 ( n = @number@ census tracts = @number@ ) .
Social changes and medical advances have increased longevity , but the conditions governing healthy vs unhealthy cardiovascular ( CV ) aging are not fully known.
Social cognition involves social knowledge , perception and processing of social cues , and the representation of mental states.
Social cognition matures dramatically during adolescence and into early adulthood , supported by continued improvements in inhibitory control.
Social comparisons and practical solutions are strategies that facilitate adaptation and acceptance of the new situation due to LEoP.
Social conditions in childhood and adulthood were assessed using self-reports.
Social conduct impairment / disinhibition , loss of insight , and inflexibility were the most frequent clinical features observed at onset.
Social connections were measured at baseline ( 1994-96 ) , and survival status and cause of mortality were identified in @date@ .
Social desirability correlated with all self-report measures , and covarying social desirability diminished the mood-MSE relationship while enhancing the relationship between MSE and objective memory.
Social disparities in optimism were evident.
Social engagement and depressive symptoms were measured for @number@ residents with the Minimum Data Set of the Resident Assessment Instrument.
Social engagement comprises various aspects which need to be taken into consideration when studying cognition.
Social engagement is a lifestyle factor that has received much attention in preventative research.
Social engagement is positively related to life satisfaction ( β = @number@ p < @number@ ) .
Social engagement patterns were examined with a list of @number@ social engagement activity related questions.
Social engagement was assessed with @number@ questions.
Social engagement was negatively associated with both onset and progression of disability , even after adjustment for health status.
Social Environment and Biomarkers of Aging Study is a nationally representative study of health outcomes in the Taiwanese population.
Social factors , in particular those relating to social isolation , constitute a risk for incident MDD.
Social identification , personal identity strength , cognitive ability and well-being were measured at the commencement of the intervention and @number@ weeks later.
Social inhibition was not found to have any effect on somatization , although hypothetically it should.
Social integration is increasingly recognized as key to successful aging ; however , definitions and assessments vary greatly across gerontological studies.
Social interaction could also be reduced in this age group due by limited mobility caused by chronic conditions.
Social isolation , contributed to physical inactivity ( @percent@ ) and hypertension ( @percent@ ) .
Social isolation , loneliness , poor verbal communication , and cognitive reserve depletion might causally link ARHI with cognitive impairment.
Social isolation , social disconnectedness , and perceived isolation were measured from the Lubben Social Network scale-6.
Social isolation was also more prevalent for HIV + ( @percent@ ) than uninfected participants ( @percent@ , P < @number@ ) .
Social isolation was measured with the Lubben Social Network Scale.
Sociality permeates each of the fundamental motives of human existence and plays a critical role in evolutionary fitness across the lifespan.
Socially disadvantaged children face increased morbidity and mortality as they age.
Social marketing interventions , along with audience segmenting are explained.
Social measures were also important correlates of vulnerability , indicating that both neurocognitive and social cognitive deficits may contribute to financial exploitation in later life.
Social media thus warrants further evaluation as a potential tool to help foster greater adherence to screening guidelines.
Social minorities ( racial , ethnic , cultural , and sexual minorities ) are at high risk for all three.
Social motives were associated with decreased likelihood of drinking alone , but negative affect was associated with decreased likelihood of drinking outside one's home.
Social network and contact with family and friends , and engagement in leisure and social activities were important support mechanisms.
Social network characteristics were measured using the Berkman-Syme Social Network Index.
Social networks are based on ties with family and friends.
Social networks of older adults with HIV have been characterized as fragile , with a greater reliance on friends as compared to family.
Social network types have been proved to have significant impacts on older population's health outcomes.
Social network type was found to be associated with each of the well-being indicators after adjusting for demographic and health confounders.
Social organization correlates with longevity across animal taxa.
Social participation and sense of belonging questions came from Statistics Canada surveys.
Social participation has been linked to healthy aging and the maintenance of functional independence in older individuals.
Social participation is a criterion for successful aging.
Social participation is a key determinant of successful and healthy aging and therefore an important emerging intervention goal for health professionals.
Social participation level was examined using question items from the National Health and Nutrition Survey in Japan.
Social preventive measures need to involve early interventions in order to augment their effectiveness against mental frailty.
Social , psychological and physical health factors could contribute to the experience of loneliness.
Social representations were analyzed through a structural focus , based on the content analysis.
Social science should provide information on that progress , or its absence.
Social service referrals were made directly to community agencies.
Social services and psychological interventions are needed to promote health and well-being among U.S. Chinese older adults.
Social support and community engagement were positively associated with both resilience and mastery.
Social support and coping partially mediate the association between adverse childhood experiences and quality of life.
Social support and life events were assessed using the Comprehensive Assessment and Referral Evaluation ( SHORT-CARE ) inventory.
Social support and physical activity mediated the relationships between stress and mental health , except depression.
Social support and strain were measured by the scales drawn from the Health and Retirement study.
Social support and the incongruence between preferred and actual social contact were significantly associated with decreased psychological distress for several outcomes.
Social support changes were measured over @number@ year from baseline to follow-up round @number@
Social support has a positive influence on cognitive functioning and buffers cognitive decline in older adults.
Social support has been shown to buffer the relationship between life stress and psychological distress in late life.
Social support included positive support and negative strain.
Social support is a resource for the older people that effectively reduces psychological distress , with or without specialized health service provision.
Social support is commonly measured with the Interpersonal Support Evaluation List ( ISEL ) , a 40-item , 4-factor , self-report measure.
Social supports were measured by asking the frequency of receipt of support from spouse , non-spouse family members , and friends.
Social support was assessed by marital status and frequency of contact with friends , relatives or children.
Social support was assessed using the Medical Outcomes Study Social Support Survey measure ( MOS-SSS ) of which psychometric properties were examined through factor analyses.
Social-transfer payments were all significantly larger in patients than in control subjects.
Social-transfer payments were included to illustrate the effect on national accounts.
Social withdrawal was defined as a decline in social engagement without distress while social isolation was defined as a decline in social engagement with distress.
Social work education plays a critical role in preparing social workers to lead efforts that improve health.
Social workers aim to prevent ongoing gaps in care for older LGBT adults that can lead to negative individual and social consequences.
Social workers are often the key link between older adults , their families and community-based services.
Social work faculty's low bias and perceived need for gerontological content in curricula is an encouraging finding for gerontological social work education.
Social work researchers , practitioners and allied professionals may utilize the ASD-Mandarin instrument to measure young people's attitudes towards older adults in China.
Social work with older people has both therapeutic and practical components.
Societal aging raises challenging ethical questions regarding the just distribution of health care between young and old.
Societal efforts to address racial discrimination in concert with efforts to promote positive in-group racial attitudes may protect against premature biological aging in this population.
Societies with low levels of trust may lack the capacity to create the kind of social supports and connections that promote health and successful aging.
Society allows adolescent exuberance and creativity to be bounded and explored in relative safety.
Society places great emphasis on the presence of hair.
Sociocultural conceptualization of the symptoms of dementing diseases remains obscure in many countries.
Sociocultural determinants of HPV-related disease , as well as the impact of forces that result in social destabilization , demand further study.
Socio-demographic and biomedical data were collected and cognitive status was assessed using the Mini-Mental State Examination ( MMSE ) .
Socio-demographic and clinical characteristics were used as potential determinants of PTSS.
Sociodemographic and clinical data , activities of daily living , functional capacity , and physical activity were also evaluated.
Socio-demographic and dietary habits data were collected at baseline.
Sociodemographic and family functioning data were collected , and cognitive function was assessed in all subjects using the Mini-Mental State Examination.
Socio-demographic and psychosocial factors associated with health-related quality of life are analyzed.
Sociodemographic , anthropometric , clinical and biochemical data were collected.
Sociodemographic characteristics associated with EM did not differ by definitional criteria.
Socio-demographic , clinical and pain data and medication use were assessed at baseline for the association with falls in the following year.
Socio-demographic , clinical , psychological and lifestyle factors were assessed using standard questionnaires and procedures.
Sociodemographic covariates-adjusted Cox regression models were applied to estimate hazard ratios ( HRs ) and @percent@ confidence intervals ( CIs ) .
Sociodemographic data and medical history were obtained from the medical records.
Sociodemographic data and self-reported physical activity were analyzed using descriptive statistics and Cochran's Q , respectively.
Sociodemographic data , practice of regular physical activity and drug intake data were collected.
Socio-demographic determinants , co-morbidities , functional and cognitive evaluation , and incident mortality were taken into account.
Sociodemographic , economic , family and social network , and health and functioning variables were selected.
Socio-demographic , environmental and general health status were evaluated during the medical interview.
Sociodemographic factors considered were gender , age , marital status , monthly household income , education , employment status and city of residence.
Sociodemographic factors differentiate the motivations for consumption of functional food.
Sociodemographic , lifestyle , and health-related factors were examined in multivariate models of ED and low SD.
Sociodemographic measures included age , sex , education , poverty status , and perceived neighborhood disorder.
Socio-demographic , psychosocial , and specific migration data were also collected.
Sociodemographics and other health-related information were collected during the exam.
Sociodemographics and other health-related information were collected during the exam.
Sociodemographics , medical conditions , and dietary and lifestyle habits were derived throughout standard procedures.
Sociodemographic variables , sensory status , cardiovascular risk factors , comorbidity , and geriatric tests were analyzed.
Socio-ecological indicators ( GII , GNI , and DCI ) in Europe appear to have a latent effect on OLE levels.
Socio-ecological models suggest that weather conditions are determinants of PA and may bias relations between other environmental factors and PA.
Socioeconomic adversities early in life are related to an increased probability of a low occupational grade and more stressful jobs in adulthood.
Socioeconomic and health advantages in childhood and healthier lifestyles during young adulthood explained most of the association between childhood cognitive functioning and adult cardiorespiratory fitness.
Socioeconomic-demographic characteristics and health-related behaviours were established using interviewer administered questionnaire.
Socioeconomic differences in BMI began to emerge by @number@ years old , and widened with increasing age.
Socioeconomic differences in cardiovascular mortality were not significant.
Socioeconomic disparities are associated with differences in cognitive development.
Socioeconomic factors contribute to the occurrence of frailty ; though in our study do not explain the relationship between pain and frailty.
Socioeconomic factors do not influence AD public cost , but do affect the level of out-of-pocket expenditure.
Socioeconomic indicators included education , household income , and net worth.
Socioeconomic inequalities in health are commonly known to decrease at late age.
Socioeconomic inequalities in mortality were observed.
Socioeconomic position ( SEP ) across life is found to be related to adult physical performance , but the underlying pathways are not well characterized.
Socioeconomic position was a stronger correlate of health than psychological working conditions alone.
Socioeconomic resources , such as education , prevent disability but are not readily modifiable.
Socioeconomic status and education level were not mentioned in the text.
Socioeconomic status explained the largest portion of differences between regions in @number@ but a smaller portion of the trends.
Socioeconomic status is associated with health disparities , but underlying psychosocial mechanisms have not been fully identified.
Socioeconomic status ( SES ) was assessed using information about the current / most recent occupation and also net wealth.
Socioeconomic status significantly interacted with genes that affect fiber integrity : heritability was higher in those with higher SES.
Socio-economic status was assessed by years of full-time education and occupational social class.
Socioeconomic status was defined based on validated classification scores.
Socioeconomic status was measured by occupation and education , and health status by functioning and comorbidity.
Socioeconomic status was measured using occupation.
Socioemotional disinhibition was measured using the Neuropsychiatric Inventory.
Sociological insights in this field come from the view that dementia and social class are embedded in social relations.
SOC measures the extent to which an individual conceptualizes the world as comprehensible , manageable , and meaningful.
SOD1 , CAT , and HSP27 levels were not significantly different between groups.
SOD1G93A ALS mice were divided into three groups : sham , intravenous ( IV ) , and intracerebroventricular ( ICV ) groups.
SOD1 G93D mutation has been described in amyotrophic lateral sclerosis ( ALS ) patients with slowly progressive disease.
SOD1 , TARDBP , OPTN , TBK1 , and NEK1 were sequenced in @number@ cases and @number@ controls.
SOD activity was measured in erythrocyte hemolyzates by Ransod commercially available test.
SOD and MDA levels in culture supernatant were detected.
SOD is a metalloenzyme and it acts as an excellent antioxidant to protect the body from superoxide radicals that are generated in the biological system.
Sodium bicarbonate but not saline administration to these mutant mice markedly prolonged their survival , decreased their protein catabolism and attenuated organ abnormalities.
Sodium-hydrogen exchangers ( NHEs ) and aquaporins ( AQPs ) are key regulators of cell volume and intracellular ions both in physiological and pathological conditions.
Sodium levels and plasma volume changes were not different between sexagenarians and octogenarians ( all p > @number@ ) .
Sodium nitrite may be a novel therapy for treating arterial aging in humans.
Sodium nitroprusside ( SNP ) was used as a NO donor compound and cell viability was evaluated by MTT assays.
SO elderly people have lower physical functional levels than healthy counterparts.
So far , aging studies have concentrated on endurance athletes.
So far , gastric ulcer in elderly persons is considered proximal gastric ulcer due to corpus-predominant atrophic gastritis.
So far , genetic variation only explains ~20-25 % of the variability of human survival to age 80 + .
So far , hearing aids and cochlear implants are the only possibility to \ "treat \ " profound deafness.
So far , however , how LIF mediates cytoskeleton contractility remains unknown.
So far , however , it has been used sparingly to study immune ageing.
So far , however , the empirical research examining these models does not take stabilisation into account.
So far , little data for EC-IC bypass surgery in elderly patients suffering occlusive cerebrovascular disease are available.
So far , little information is available on the association between polypharmacy status and mortality.
So far , little is known about the contribution of genetic polymorphisms to the risk of VaD.
So far , no biological explanation has been suggested for the positive effect of delivering sons later in life.
So far , no medical treatment has been suggested to alleviate this morbidity.
So far , no pharmacologic interventions have changed the onset or progression of AD and their use is accompanied by side effects.
So far , @number@ variables on health conditions and a variety of exposures , including biomarkers and genetic data have been harmonized.
So far , predictors have not been analyzed separately for different age groups.
So far , public health researchers have largely ignored genetic discoveries , and geneticists have ignored important aspects of population health science.
So far , several studies have shown that TLRs play a role in obstructive nephropathy but the contribution of TREM1-DAP12 herein is unknown.
So far , the cellular and molecular basis of inflammation is not fully understood.
So far , the German version of the CANE has not been established in health services research.
So far , there are four different patient controllers available on the European market.
So far , there has been no data about the presence of MS in young hypogonadal patients.
So far , there is no single theory that fully explains all facets of aging.
So far , there was no local recurrence.
So far , the validity and reliability of the Katz-15 scale is unknown.
So far , to our knowledge , no large-scale genetic study of dementia with Lewy bodies has been done.
Soft tissue augmentation and volume correction in these areas may be an effective strategy for facial rejuvenation.
Soft tissue augmentation is a process of implanting tissues or materials to treat wrinkles or soft tissue defects in the body.
Soft-tissue augmentation provides a minimally invasive option for patients seeking to look younger.
Soft-tissue calcification is associated with aging , common conditions such as diabetes or hypercholesterolemia , and with certain genetic disorders.
Soft-tissue composition was found to be heterogenous , with varying distributions of tissue at different levels of the columella.
Soft tissue filler injection has been a very common procedure worldwide since filler injection was first introduced for soft tissue augmentation.
Soft tissue options include the conversion from a subpectoral to a subglandular position to use the pectoralis major , or a latissimus dorsi muscle flap.
Soft tissue thickness was measured using ultrasound.
Software Implementation : An implementation of the algorithm in R is available at : @url@
( SO ) had glycemia ( > 110 mg / dl ) .
Soils were measured for bioaccessibility at different aging periods.
So , it can be considered as an appropriate tool to evaluate the social function and social motivation of older persons with and without depression.
So , it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components.
So it is no wonder that almost every heart disease is related to metabolic shift.
So its expression is always tightly controlled in cells.
Solar elastosis also correlated with increased number of lymphangiectases.
Solar lentigines are a common sign of aging in Asians , who often asked for treatment.
Solar lentigines , especially those which are light in color , show somewhat limited response to pigment lasers and intense pulsed light sources.
Solar UVA exposure plays a causative role in skin photoaging and photocarcinogenesis.
Solid amyloid plaques in the affected brain tissues characterize AD.
Solid evidence is lacking to guide optimal pharmacotherapy in most end-of-life settings , especially in non-cancer diseases and very old patients.
Solid lipid nanoparticles ( SLNs ) are categorized as a new generation of lipid nanoparticles consisting of a complete solid lipid matrix.
Solid nanodelivery systems include nanocrystals , lipid nanoparticles , and polymeric nanoparticles.
Solid-organ transplant recipients have an elevated risk for some malignancies because of the requirement for immunosuppression [ @number@ ] .
Soluble fibre was inversely associated with triglycerides and apolipoprotein B100.
Soluble Klotho can be found in the blood , cerebrospinal fluid , and the urine of mammals.
Soluble RAGE ( sRAGE ) acts as a decoy of RAGE and has been used to treat pathological vascular conditions in animal models.
Soluble receptor for advanced glycation end products ( sRAGE ) can decoy the toxic AGEs and is considered to be a protective factor.
Solutions are needed to satisfy care demands of older adults to live independently.
Solutions to reduce H. pylori prevalence and its sequelae should focus on people at greatest risk of the infection.
Somatic ( acquired ) mtDNA mutations are also associated with degenerative diseases and with normal human ageing.
Somatic and psychological parameters are lacking which would be able to signalize the actual level of the aging process in a given person.
Somatic cells can be reprogrammed into induced pluripotent stem ( iPS ) cells by ectopic expression of four transcription factors.
Somatic cells change continuously during culture expansion-long-term culture evokes increasing cell size , declining differentiation potential , and ultimate cell cycle arrest upon senescence.
Somatic cellular senescence ( SCS ) describes the limited ability of cells to divide.
Somatic copy number aberrations ( CNA ) represent a mutation type encountered in the majority of cancer genomes.
Somatic illness , bereavement , and attention to suicide in the media were more common among older adults than middle-age adults.
Somatic inclusions undergo a stage-like maturation , with progressive compaction coinciding with decreased soluble somatic and nuclear alpha-synuclein.
Somatic mosaicism as the cause of other diseases is becoming more appreciated.
Somatic mosaicism is well appreciated as a cause of cancer and , possibly , aging.
Somatic mutation is not evenly distributed and exhibits certain micro-sequence specificities.
Somatic mutations are difficult to detect in bulk tissue samples.
Somatic mutations of NFE2L2 leading to NRF2 accumulation promote cell survival and drug resistance in cancer cells.
Somatic rearranged during transfection ( RET ) mutations are reported in 40-50% of sporadic medullary thyroid carcinoma ( sMTC ) patients with prognostic significance.
Somatic stem cells ensure tissue renewal along life and healing of injuries.
Somatic symptoms of depression increased concurrently with declining processing speed , which may reflect common neurodegenerative processes.
Somatic symptoms on the DSSS also attenuated significantly during the study period ( P < @number@ ) .
Somatization was elicited from the somatization subscale when using the Symptom Checklist SCL-90 instrument.
Somatometric measurements , biochemistry , and hematologic parameters were analyzed.
Somatosensory evoked potentials ( SEPs ) enabled the objective evaluation of somatosensitivity in both groups.
Somatostatin analogues have shown to be effective in these patients.
Somatotroph adenomas are rare in the aging population.
Somatotype was determined by the Rees-Eysenck index.
Some acquire a locals spouse and raise a second family.
Some act to promote normal life span and stress resistance , whereas others inhibit these phenomena.
Some adults without ADs / POA perhaps would have completed advance care documents , if they had had received more information and support.
Some advanced schistosomiasis patients are worse ; therefore the chemotherapy and salvation work still should be strengthened.
Some affected individuals have intellectual disability , seizures , undescended testicles in males , and teeth and hair abnormalities.
Some agents produce only one of these actions , whereas others have multiple effects.
Some age-related neurodegenerative diseases have an etiology that is related to mitochondrial dysfunction.
Some aging clocks that have been proposed include the suprachiasmatic nucleus , the hypothalamus , involution of the thymus , and cellular senescence.
Some aging clocks that have been proposed include the suprachiasmatic nucleus , the hypothalamus , involution of the thymus , and cellular senescence.
Some aging men develop a condition of suppressed serum testosterone levels , which is associated with diffuse sexual , physical and psychological symptoms.
Some analytes including insulin and DHEA-S required additional gender partitions for specific age groups.
Some antidepressants may reduce the expression of inflammation markers.
Some applications deal with lifestyles suggestions and tips.
Some approaches to use reparative autophagy for prevention of cell degeneration are considered.
Some areas , within the amygdala-hippocampus complex , which are affected early in life by schizophrenia , age in a physiological way.
Some are ingested in substantial quantities from nutritional sources , more are produced by medicinal plants , and some of them are taken as drugs.
Some argue there are too few providers already ; others say our current supply-demand problems lie with efficiency.
Some aspects ( e.g. , different task formats ) , however , hamper the comparability of results among different populations and the reproducibility between laboratories.
Some aspects of the morphological and electrophysiological alterations promoting AF have been studied extensively in animal models.
Some attributes of neighborhood environments are associated with physical activity among older adults.
Some authors described that HOA increases with age in adults and that aging disrupts compensation between corneal and internal aberrations.
Some authors have proposed that a deregulation of LMNA affects the differentiation potential of stem cells.
Some authors predicted elderly individuals to be the most rapidly growing subgroup of patients currently sustaining acetabular fractures.
Some believe that menopause is programmed and purposeful ( grandmother theory ) .
Some body of evidence justified suicide in elderly as the final auto determination to preserve the person's dignity , and quality of life.
Some , but not all body systems , exhibit signs of premature or accelerated aging.
Some , but not all , have pensions and modest assets.
Some caloric restriction-related outcomes , such as cause-specific mortality and lifespan , are not practical for human clinical trials.
Some caregivers believe in providing relief from suffering , but are uncertain about making decisions regarding dialysis therapy initiation and discontinuation.
Some causes are inherent with aging , such as gross structural and cellular changes , decrease in physiologic function , and lowered vascular compensatory reserve.
Some CDPs could be used as biomarkers in these pathologies.
Some challenges to scientists are finally proposed for future proteomic investigations to solve main drawbacks in this research field.
Some changes are normal ones , but may be misunderstood as abnormal by prejudice and ignorance of the senile sexuality.
Some changes are of a low or subtle extent , whereas some others show significant amplitudes.
Some characteristics of the observed patterns need to be seen in the context of our cohort , featuring particularly high γ-GT levels.
Some circadian clock genes have been described as tumor suppressors , while other genes have less clear functions in aging and cancer.
Some commentators have suggested that this is not a meaningful epidemiological trend rather a methodological artifact.
Some common biological and medical changes in old age might actually enhance longevity and represent novel targets for improving health in older people.
Some co-morbidities , such as substance abuse or depression likely play significant roles in the neuropsychiatric profiles of some HIV-infected patients.
Some conclusions : Until @number@ the absolute number of 75-plus doubled to about @number@ million persons , but the number of informal caregivers will decrease.
Some conditions might have a different meaning in certain groups of elderly subjects , like in frail people or older patients with heart failure.
Some contextual factors , such as resources and the accessibility of organizations and training facilities , are important and contributed indirectly to quality of life.
Some controversial medical prescriptions are not adequately controlled by the health service.
Some countries experienced improved collaborations , others had difficulties finding a socially integrated location for MCSP.
Some cross-sectional and case-control studies reported better cognition in those with higher dietary thiamine intakes , but the data remains inconclusive.
Some CSF-tau may leak into the blood.
Some data concerning left atrial dilatation as an inalienable component of the cardiovascular continuum in essential hypertension are submitted.
Some data suggest being female , and having a lower household income and less than a high-school education were associated with concurrent use.
Some dementias , like semantic dementia and Alzheimer's disease , are linked to alteration of semantic memory.
Some dietary components of foods possess biological activities which influence circadian rhythms in humans.
Some differences between the @number@ groups may reflect changes in choroidal morphology associated with aging.
Some differences in the risk factor profile emerged between the homebound and the semi-homebound populations.
Some differences were noted between women with cancer and those without.
Some different ways old lesbians identify that may affect policy decision and research analysis are included.
Some disorders linked to mutations in RBPs include : amyotrophic lateral sclerosis , frontotemporal dementia and spinal muscular atrophy.
Some disorders show specific neuroimaging features , while examination of the cerebrospinal fluid awaits markers for in vivo stratification of cases.
Some distinguished Italian scientist working abroad is also mentioned.
Some drivers may be able to compensate for the increased crash risk by avoiding complex driving situations or restricting their driving.
Some dual-polymerizable resin cements used to bond porcelain laminates were shown to undergo color changes during service.
Some dual-process studies have suggested that recollection is impaired and familiarity is spared in PD , yet others have found the opposite.
Some endoscopic changes requiring biopsy and morphological studies are revealed.
Some enhanced inflammatory or innate immune activation markers are interesting but still not validated for the patient's follow-up.
Some enzymes ( GAPDH , retinal dehydrogenase @number@ and carbonyl reductase @number@ ) may be involved in and / or accelerate this process.
Some estrangements appeared to result from a cultural bias towards the nuclear family form.
Some evidence indicates a high rate of memory loss , while other evidence suggests a benefit in dementia prevention.
Some evidence of typing impairment is inconsistently reported with active workstation alternatives ; the finer motor skills required for mouse-related tasks may be more affected.
Some evidence suggests that the benefits of R / S to health and longevity would be more present in populations from more religious regions.
Some examples of data mining methods implementation in gerontology are presented.
Some examples will be given.
Some expected hearing impairment with older age , thus they found it easier to accept wearing HAs than they may have at a younger age.
Some factors increase the risk of adenotonsillar surgery and should be excluded before contemplating surgery in a secondary care setting.
Some family members are critical for mediating programmed cell death in development.
Some features and complications of DM did associate with FRAX scores.
Some features of sporadic inclusion body myositis ( s-IBM ) suggest that there is acceleration of the normal ageing process in muscle tissue.
Some felt stigmatised by healthcare professionals , but others said their drug use was acknowledged and people were compassionate towards them.
Some females were dissected at different physiological stages to observe the ovaries development.
Some filtering technique is also applied for noise reduction.
Some functions such as bitterness revival are used more often by people with depression or anxiety.
Some gastrointestinal issues may be more common in the elderly population and possibly in older women.
Some gender differences were found.
Some groups have advocated using self-reported ancestry or carefully selected single-nucleotide polymorphisms , also known as ancestry informative markers , to sort individuals into populations.
Some had never heard of CS.
Some hallucinations occurred out of boredom , which exacerbated the sensory deprivation experienced by these persons , thereby increasing the likelihood of hallucinations.
Some have interpreted these associations to suggest that obesity causes intellectual decline in the first half of the life course.
Some health care providers are unaware of the effective low-risk treatments currently available.
Some health decision makers and providers ( @percent@ ) thought that they needed more village doctors.
Some hypothalamic neurons remain intact and active during the process of aging , others become even hyperactive , which may lead to disorders.
Some hypotheses have been drawn to explain the variability of the DUOX2 / A2 phenotype.
Some hypothesize that aging in humans is a cumulative process of macromolecular and mitochondrial damage starting years , even decades before any symptoms arise.
Some important recent clinical studies point to new treatments and add to the existing body of research on corneobiology.
Some indicators of cognitive function may also improve with ST.
Some individuals are able to integrate the conditions of old age while others respond in ways that inhibit effective integration.
Some individuals delay , escape or survive much of this age-related decline and live past age @number@
Some individuals fear living with advanced dementia and may even commit suicide if they receive dementia diagnosis.
Some individuals utilize compensatory strategies that may result in successful hearing aid use.
Some inflammation markers were identified such as interleukin-6 , C-reactive protein or tumor necrosis factor alpha.
Some interactions between age and shift type and shift system have been found , however.
Some interventions ( n = @number@ ) were deemed unlikely to provide any benefit ( Grade D ) .
Some investigators propose that late-onset schizophrenia may be a prodromal symptom of dementia.
Some kinds of mushrooms , cereals and germinated legumes or seeds are also good dietary sources of melatonin.
Some laboratories recently developed PET tracers to detect tau pathologies in patients with AD ( @number@ ) ) .
Some lipid- and blood pressure-lowering bioactives were studied for their impact on human vascular health , particularly as regards endothelial function and arterial stiffness.
Some liver diseases are particularly frequent in the elderly , e.g. chronic hepatitis C and hepatocellular carcinoma.
Some loss of visual performance may therefore precede retinal structural changes that can be detected reliably using conventional fundus imaging techniques.
Some machines can be used without any anesthesia or only with topical cooling or cryospray.
Some mastication parameters are slightly modified by age , but ageing itself does not impair mastication , as the adaptation possibilities remain operant.
Some MCI patients show white matter hyperintensities in magnetic resonance imaging , revealing subcortical vascular damage ( SVD ) .
Some measures of muscle strength may improve , although consensus was not reached.
Some mechanisms for this increase are aging ; autoimmunity ; congenital , metabolic and degenerative disorders ; and AIDS.
Some medical disorders can impair performance , increasing the risk of driving safety errors that can lead to vehicle crashes.
Some medical schools have implemented strategies of intentional socialization between their students and older adults to improve the students ' attitudes.
Some memories about events can persist for decades , even a lifetime.
Some men between the ages @number@ and @number@ years develop complaints and symptoms reminiscent of menopausal complaints in women.
Some mental problems of aging , especially the occurrence of dementia , are not easily noticed in early stage.
Some metals , such as copper , aluminum , zinc and iron et al , can also have close relationship with AD.
Some MMDs may be difficult to open and access , especially for patients with cognitive impairment.
Some modifications of the simple asexual Penna model , enriched by epigenetic contributions , are presented.
Some more recent methods of spectacle and contact lens correction are described in more detail.
Some negative dose-dependent cortical associations persisted after controlling for all covariates.
Some newer drugs are better tolerated or safer than older ones , but none is more effective.
Some NHS trusts have introduced geriatric admission-avoidance systems , but evidence of their effectiveness is lacking.
Some nominally significant effects were observed ( i.e. , covariate-adjusted differences between genotype groups at p < @number@ ) .
Some non-inferential physiological measurements can enhance animal models of human neurodevelopmental anxiety disorders.
Some novel issues were raised as well as a number of those discussed within the bioethical literature.
Some nuclear-encoded subunits of cytochrome c oxidase are present as tissue-specific isoforms.
Some nuclear expressions of MUC2 and MUC6 were noted in children without intestinal metaplasia.
Some objects of special value and other cherished objects materialized the connections between generations within a family.
Some observational studies have reported inverse associations between diabetes and subsequent glioma risk , but possible mechanisms are unclear.
Some of ghrelin's changes may contribute to the regulation of food intake and weight in children.
Some of immunological changes are apparently a consequence of joined actions of radiating and not radiating factors.
Some of the affected children exhibited mental retardation.
Some of the age-related decline in speech perception can be accounted for by peripheral sensory problems but cognitive aging can also be a contributing factor.
Some of the changes in medical nutrition therapy and specialized nutrition support are addressed.
Some of the common molecular pathways activated include : endoplasmic reticulum stress , reactive oxygen species formation , and glutamate excitotoxicity.
Some of the consequences of these findings and new open questions arising from them are discussed.
Some of the disturbances of gait are focused on step length , cadence , and temporal variability of gait cycle.
Some of the effect of transient reprogramming may result from increased proliferation and enhanced function of adult stem cells.
Some of the effect was explained by social and health behaviors , but most of the effect was explained by health outcomes.
Some of the identified genes with differential methylation ( DLG associated protein @number@ mechanistic target of rapamycin ) have previously been associated with traumatic stress.
Some of the inflammation markers and autonomic nervous system dysfunction were also independently correlated with carotid IMT increase.
Some of the main topics being investigated are those related to oxidative stress and aging.
Some of the metaphase chromosomes showed no telomeric signal at chromatid ends , suggesting an aberrant telomere structure.
Some of them have been shown to cross the BBB and have been tested either for diagnosis or treatment of AD.
Some of the more common chronic diseases are respiratory.
Some of the most commonly utilized treatments require lifelong use , requiring high patient adherence to ensure effectiveness.
Some of the most highly reactive aldehydes produced endogenously are 4-hydroxy-2-nonenal , malondialdehyde , acrolein , crotonaldehyde and methylglyoxal.
Some of the most notable discoveries are their extreme insulin sensitivity in the presence of obesity.
Some of them would be willing to make a proxy decision to stop feeding in the absence of advance directives.
Some of the nonagenarians ( n = 8 ) were also recruited for follow-up after one year. cf-DNA was extracted using two different methods.
Some of the novel modulators have also been shown to participate in the control of melatonin biosynthesis and melatonin receptor expression.
Some of the participants lived in their own homes , some in service houses and some in nursing homes.
Some of the pictures depicted include the picture of a gradually declining memory of an Alzheimer's disease patient and the challenges of elderly care.
Some of the presented curves in female patients were observed beginning two decades after that of male patients , and at lower levels.
Some of the problems confounding this research can be reduced by harmonising and pooling data across studies.
Some of these actions might even be harmful , and could play an important role in aging of connective tissues with loss of function.
Some of these age-dependent modifications mediated by hyaluronan will be reviewed and commented , especially the upregulation of matrix degrading enzymes as MMP-2 and MMP-9.
Some of these approaches can now be applied to clinical practice.
Some of these are located in the alpha-helical central rod domain required for the polymerization of the nuclear lamins into higher order structures.
Some of these associations may be driven by women with dementia in whom disturbed sleep and cognitive performance share an underlying neuropathological basis.
Some of these changes are visible , whereas others are not and may be elicited during the patient encounter.
Some of these changes in the enzyme properties are due to their reduced expression and / or structural modification by reactive oxygen species.
Some of these changes may prove helpful for clinical and forensic practitioners , particularly when evaluating less severe cognitive impairments.
Some of these functional abnormalities can be explained by aberrant DNA damage response and chromosomal instability.
Some of these functions undergo daily variations , such as temperature or water loss , suggesting the presence of time-keeping mechanisms.
Some of these have shown promise in controlled clinical trials in OA patients.
Some of these in vitro potency assessments correlated with , and were relevant to , the observed in vivo actions.
Some of these markers have been identified in cells from age-related pathologies.
Some of these models have been crucial for the development of therapeutic approaches in humans.
Some of these phytochemicals appear to have potential as possible therapeutic interventions to offset key components of the secondary injury cascade.
Some of these practices may require additional time or resources.
Some of these proteins have previously been shown to interact with WRN , whereas most are new partners.
Some of these reactions are nonspecific to different injuries ; however some , such as the appearance of inclusion bodies , can be highly disease-specific.
Some of these sex differences may be related to sexual dimorphism in brain structure , as it emerges during prenatal and post-natal development.
Some of the support for this hypothesis has come from animal research.
Some older adults , known as \ "Supernormals \ " , maintain excellent memory.
Some older patients develop symptoms of clinical heart failure after closure of an atrial septal defect ( ASD ) .
Some open questions for research are suggested.
Some outcomes improved for all caregivers , whereas some improved for caregivers experiencing more initial difficulties or caring for veterans with more-severe impairments.
Some papers have suggested surgical treatment to repair femur fractures after long-term treatment with bisphosphonates.
Some participants could not attend the whole program due to poor health or difficulties securing transport.
Some participants wanted to spare their children the burden of having to decide on what to do with their possessions.
Some pathologic mechanisms related to diseases may help to explain frailty.
Some patients are frail as they have impaired homeostatic mechanisms , deteriorated physiological systems , and limited functional reserve.
Some patients exhibit skin xanthomas and severe hyperlipidemia.
Some patients reported bearable pain in the temporal region and tension during mouth opening.
Some patients saw the aids as helping to maintain independence , others as casting doubt on their independence.
Some patients with GBA heterozygous mutations develop clinical features of DLB.
Some patterns are stronger for daughters and biological children who tend to have stronger relationships with their parents.
Some PD patients with normal cue-information memory changed strategy to initiate smooth tracking.
Some people will turn to adapted sports to meet their need to be involved in occupations.
Some @percent@ of these dentists expressed to be suffering from the cervical pain , whereas , @percent@ complained about back pains and @percent@ shoulder problems.
Some peroxisomal abnormalities , which are often not compatible with life or normal development , were identified in severe demyelinating and neurodegenerative brain diseases.
Some personal-level determinants ( age-related barriers ) and environment-level factors ( car dependence , bus services ) were shared across samples.
Some pharmacological interventions have already shown promising results.
Some physicians cite an excessive bleeding risk as one reason for withholding oral anticoagulation therapy from older patients with atrial fibrillation.
Some physiological and disease processes associated with ageing may reduce vision and , in some cases , this reduction in vision cannot be treated.
Some plasma samples were first depleted of albumin and immunoglobulins to improve detection of lower abundance proteins.
Some practices / drills , moderate exercise , mastication , and a cognitive task itself could enhance cognitive function.
Some predisposing factors - as aging , diabetes , hypertension - induce and maintain electrophysiological and ultrastructural remodeling that usually includes fibrosis.
Some primary lines also tend to merge to form thin new wrinkles.
Some prognostic metrics have been reported to guide better patient selection ; however , universal risk stratification measures have not been established.
Some proponents of non-programmed aging still contend that their non-programmed theories are superior despite the new mechanics concepts.
Some proteins identified had little well-known function in the human testis , as follows : AKR7A3 , FDXR , PGAM1 , @date@ and HMGCS2.
Some QOL factors identified in the regression analyses can be used as targets to improve QOL.
Some quick screening tests for mobility disorders can be performed in a clinical praxis.
Some randomized controlled trials have shown that frailty screening in primary care , with subsequent CGA and intervention , can prevent adverse outcomes.
Some rare autosomal dominant pathologies are clearly related to paternal age.
Some recent data suggest harm when testosterone was given to men with limited mobility.
Some recent evidence favors the latter hypothesis , but determining the best approach to study how deficits scale remains a key goal for understanding aging.
Some recent large observational studies now support these findings.
Some recently produced cements are described as being color stable , but scientific data are not available.
Some recent patents and inventions for the treatment of Alzheimer's disease have also been discussed.
Some recent studies however indicate that cerebellar Purkinje cell ( PC ) loss is the pathological basis of ET in most patients.
Some recommendations are provided for the major subtypes of lymphomas including the antitumoral treatment and primarily the optimal supportive care.
Some regions of interest had a loss of white matter connectivity at baseline.
Some regulatory factors of taste cell differentiation and degeneration have been identified , but our understanding of these aspects of taste bud homoeostasis remains limited.
Some reports have identified factors associated with the acceleration of the epigenetic age.
Some reports suggest that measures of general adiposity such as body mass index ( BMI ) predict better survival.
Some researchers claim that health care expenditures for older people are growing faster than for the rest of the population.
Some researchers have gone so far as to suggest that pedestrians rely more on physical distance of a vehicle in their crossing decisions than TTA.
Some researchers have interpreted this hyperactivity as playing a compensatory role.
Some researches have linked TL shortening to increases in stress-related cortisol , but others have not.
Some research has observed an increase of more than @number@ cal per day over the weekend in American adults.
Some residents ' descriptions of their situation revealed that certain changes in social life on the ward had occurred.
Some results of Russian researchers obtained during 2005-2010 have been summarized as well.
Some root fractions of molars estimated age accurately ; however , the standard deviation was more than @number@ years.
Some scientists believe that approx.
Some screening tests can also be helpful for monitoring treatment outcomes.
Some sex differences were also observed.
Some social inequalities levelled off in higher age.
Some specialties face critical shortages and a significant percentage of physicians are aging.
Some studies also suggest statins increase the risk of new-onset diabetes.
Some studies are underway.
Some studies demonstrated that older drivers perform well compared with younger drivers.
Some studies have reported a significant inverse relationship , but others have not , perhaps in part owing to insufficient power.
Some studies have shown a loss of corneal transparency and an increase in turbidity associated with aging.
Some studies have shown a potential role for grapes or wine in slowing cognitive decline and other effects of aging.
Some studies have shown its effectiveness in the treatment of dementia.
Some studies have shown that one of the mechanisms underlying the association is that TBI may contribute to earlier onset of dementia.
Some studies have shown that polymorphisms in the insulin growth factor-1 ( IGF-1 ) signaling pathway genes could influence human longevity.
Some studies have shown that such gait disturbances were measurable years before mild cognitive impairment or dementia or walking difficulties were clinically manifest.
Some studies have suggested the medial temporal lobe while others have suggested the hippocampus.
Some studies , however , demonstrated that a high-fat diet contributes to achieving peak bone mass , along with microstructure , at a younger age.
Some studies indicate no benefits , while others highlight potential negative side effects of vitamin supplementation.
Some studies in humans indicate that LCPUFA can increase bone formation , affect peak bone mass in adolescents , and reduce bone loss.
Some studies in younger adults linked this to accelerated cellular aging , indexed by shortened telomere length ( TL ) .
Some studies provide a post hoc analysis of data in relation to older age ( ≥65 years ) , which is useful.
Some studies suggested that the risk for Down syndrome may be related to an aging grandmother.
Some studies suggest that age-specific immunity cannot be assumed.
Some suggested a postgraduate residency or mentoring option to assist NP role transition and progression and limit role confusion.
Some suggested that excess fat in the pancreas is associated with chronic pancreatitis.
Some symptoms encouraged immediate consultation ; others prompted periods of monitoring and lay management.
Some systematic reviews ( SRs ) have been published on different nonpharmacological treatments of frailty and sarcopenia using heterogeneous definitions of them.
Some systemic conditions can cause abnormal physiological maturation , and skeletal maturation is usually more delayed than dental maturation.
Some theoretical results are presented.
Some therapeutic agents like histone deacetylase inhibitors and anti-miR34a agents have been reported to be effective against age-related OA.
Sometimes it is difficult for the practitioner to decide which laser to use for what indication.
Sometimes , through the process of integration , we experience and remember these items as parts of a whole rather than as separate entities.
Some trans-eQTLs point toward novel mechanistic explanations for the association of the SNP with the GWAS-related phenotype.
Some transfer effects were found , but only in the young-old-trained participants , and they were not maintained at the follow-up.
Some treatment of LUTS have undesirable effects on the erectile function.
Some variables showed larger improvements in the usual care group two months post-discharge from therapy than in the telerehabilitation group.
Some village doctors ( @percent@ ) were at least @number@ years old.
Some VOC could be dangerous to human health , therefore it is important to determine real-time indoor and outdoor personal exposures to VOC.
Some well-characterized miRNAs were substantially enriched in WM as expected.
Some were worried that they would not find work or were concerned about negotiations with potential employers.
Somewhat surprisingly , later-born cohorts showed , on average , a steeper decline than the earlier-born cohort.
Somewhat surprisingly , research using the budding yeast has had a profound impact on our current understanding of the mechanisms involved in aging.
Some women , however , embraced the term or its meaning , as indicative of the reality of older women's sexuality and continued sexual desire.
Some wood substances such as ellagitannins can be extracted during wine aging in oak barrels.
Sonic hedgehog signaling ( SHH ) was activated by Wip1 overexpression and inhibited by Wip1 silencing.
Sonoelastography ( SE ) is a new ultrasound-based imaging technique that provides information on elastic properties and stiffness of tissues.
Sonothrombolysis induced better clot lysis in fresh thrombi with high cholesterol levels.
Soon after implantation , cell lineages bifurcate into future somatic and germ cells.
So , other approaches such as nutritional strategies are needed to limit muscle wasting and to improve muscle mass recovery in such situations.
SOP-2 also showed less theta and alpha activity.
So , parallels were sought between the changes in female and male endocrinology during that period of life.
SOP patients showed significantly higher prevalence of falls and fractures.
Sorafenib was demonstrated to significantly increase the survival of patients with advanced HCC in two prospective , randomized , placebo-controlled trials.
SORL1 has been identified as a major contributor to late onset Alzheimer's disease ( LOAD ) .
Sorting out the indications and timing for @number@ pneumococcal serotypes and @number@ pneumococcal serotypes administration is complex and presents a significant challenge to healthcare providers.
So , stability between the position of the organization and that of the volunteer is necessary.
So that we can detect the secondary cancers earlier and can treat them with long expected survival period.
So the aim of the study was to evaluate biventricular myocardial function in cirrhotic patients and its alteration with or without liver transplantation.
So , the molecular connections between aging and obesity are promising targets for bio-medical researches and innovative therapies of many health problems.
So , the study of medicinal plants which rarely cause any side effect is very important to mankind.
So , the use of animal models is essential to understand these processes in the context of different cell types and during the whole life.
So , the violence against senior people has been considered a problem of public health.
So , too , is the leadership of hospice and palliative care social workers within IPE and IPP.
So , to remain motivated , older employees seem more in need of intrinsic challenging and fulfilling jobs.
Sound localization requires precise and specialized neural circuitry.
Sounds are filtered in a spatial- and frequency-dependent manner by the head and pinna giving rise to the acoustical cues to sound source location.
Sound waves emitted by two or more simultaneous sources reach the ear as one complex waveform.
Source accuracy was equally impaired in older adults for both materials.
Source analysis revealed a dipole pair in the anterior temporal lobes.
Source estimations localized this effect within left superior parietal and left occipital areas.
Source localization studies are analyzed to examine the association between the inhibition processes that are indexed by the ERP components and their functional brain areas.
Source memory involves recollecting the contextual details surrounding a memory episode.
Source-memory was best for information that violated their ( positive ) expectations.
Source of data under study is period life tables for the Polish population , 1950-2008.
Source of the hair fibre is the hair follicle , a highly specialized skin appendage.
Source power maps in the mu-alpha and mu-beta bands were localized using Dynamic Statistical Parametric Mapping ( dSPM ) .
Sources have acknowledged a severe shortage of intensivists , yet there has been minimal discussion on the lack of critical care training opportunities.
Sources included PubMed , EMBASE , and MEDLINE databases.
SOURCES OF FUNDING : financial sponsors played no role in the design , execution , analysis and interpretation of data.
SOURCES OF INFORMATION : PubMed-MEDLINE was searched from @number@ to @number@
Sources of phthalates other than Polyvinyl chloride ( PVC ) related products are scarcely documented in Mexico.
Sources of social support were classified as spouse , children living with their elders , children living apart , and friends / neighbors.
Sources of variability should be identified and corrected for clinical use.
Sources were reviewed and coded thematically.
Source waveforms for the transient evoked fields and ASSRs were reconstructed at these locations and compared between attended and unattended tones.
Source waveforms revealed attention enhances the sustained negativity of the transient evoked responses in both adults and children around @number@ and @number@ ms.
South Africa's population is aging.
South America is one of the most heterogeneous regions in the world regarding ethnical composition and socioeconomic development level.
South Korea recently topped the list of low-fertility countries , and so this study examined the trends in parental age in this country.
( SO ) was @percent@ in women and @time@ % in men.
So we assume a role of lipoprotein ( a ) as predictor of venous thromboembolism in neoplastic patients.
So we followed up by periodic chest CT.
So , we gynecologists should be careful about bone health with understanding characteristic of bone metabolism markers.
So , what is aging ?
So , while men do not have a ' menopause' , testosterone deficiency in old age deserves serious attention.
Sox2 knockdown and overexpression of a dominant negative form of Sox2 disrupts locomotor and anatomical-histological recovery.
SOX5 encodes a transcription factor that is expressed in multiple tissues including heart , lung and brain.
Soyaethyl morpholinium ethosulfate ( SME ) and bromide ( CTAB ) are the two cationic surfactants employed in this study.
Soybean isoflavones are flavonoids with an isoflavone backbone.
Soy foods contain several components , notably , isoflavones and amino acids , that may improve cardiovascular health.
Soy isoflavone is an attractive source of functional cosmetic materials with anti-wrinkle , whitening and skin hydration effects.
Soy- or red clover- derived products containing isoflavones have been amply studied in climacteric and postmenopausal women , and confusing contradicting results have been published.
Soy protein and isoflavone ( either alone or together ) did not impact serum lipids or inflammatory markers.
Soy sauce and coffee contained N ( ε ) -carboxymethyl-lysine ( CML ) .
Space flight , bed rest as well as osteoporosis and sarcopenia experimentations have allowed to accumulate considerable evidence.
Space flown worms were found to have decreased expression of a number of genes that increase lifespan when expressed at lower levels.
Spacing was more uniform in BEL than JUV and JUV was more uniform than RES.
Spalax fibroblast conditioned media had no effect on proliferation of noncancerous cells.
Span increased with age on both tests , but relatively more in navigational than in reaching space , particularly in males.
Spanish-English bilingualism was estimated via both self-report and an objective measure of English reading level.
SPARE-AD and ADAS-Cog were found to have similar predictive value , and their combination was significantly better than their individual performance.
Spark fluorescence rise time was not a good surrogate for the duration of calcium release.
Spastic Bobath inhibiting abnormal pattern was done in the whole process of training.
Spatial and temporal characteristics of movement speed and shoulder rotation were collected over the initial approach phase and while crossing the doorway threshold.
Spatial and temporal contributions to causal perception were assessed by parametrically varying the spatial linearity and the temporal delays of the movement of the balls.
Spatial cognition and balance maintenance rely on the efficient integration of information across the main senses.
Spatial correlation information , which is usually lost in bioanalytics , pinpointed a relatively small number of potential lipofuscin components.
Spatial domains with distinct protein expression profiles were observed within each choroid plexus.
Spatial factor scores of individual spatial factors were the dependent variable in separate mixed-design ANOVAs for each temporal factor of interest.
Spatial independent component ( IC ) analysis was used to identify functional networks over all participants and all conditions.
Spatially informative orienting cues improved response times , whereas spatially neutral alerting cues did not influence performance.
Spatially , results were consistent with inferior-to-superior gradients of lesser-to-greater vulnerability.
Spatial measures did not correlate with either the MMSE or GDS.
Spatial memory performance was evaluated in a three-day moving platform Morris water maze task.
Spatial navigation is a complex cognitive skill that is necessary for everyday functioning in the environment.
Spatial navigation requires a well-established network of brain regions , including the hippocampus , caudate nucleus , and retrosplenial cortex.
Spatial navigation ( SN ) impairment is present early in Alzheimer's disease ( AD ) .
Spatial pattern separation supports spatial memory by preserving unique representations for distinct locations.
Spatial proximity of signals from different sensory modalities is known to be a crucial factor in facilitating efficient multisensory processing in young adults.
Spatial reference frames are fundamental to represent the position of objects or places.
Spatial reference memory was assessed in a Morris Water Maze ( MWM ) task at @number@ and 12months of age.
Spatial relational processing forms relational representations of objects to locations or between objects and other objects in space.
Spatial sequestration plays a central role in protein quality control and cellular fitness and represents a critical link to the pathogenesis of protein aggregation-linked diseases.
Spatial Span Backward was more sensitive to severity.
Spatial Span Forward remains relatively stable regardless of level of impairment.
Spatial Span subtest of the Wechsler Memory Scale has been viewed as an indicator of working memory and visuospatial processing.
Spatial variation of the haemodynamic stresses acting on the arterial wall is commonly assumed to explain the focal development of atherosclerosis.
Spatiotemporal and balance parameters were quantified during eight consecutive gait cycles using a motion analysis system and an instrumented treadmill.
Spatiotemporal and kinematic variables were analyzed during the TUG test with a Vicon 3-D motion analysis system.
Spatiotemporal characteristics of gait were evaluated using a computerized walkway in @number@ community-dwelling older adults with CLBP and @number@ age- and sex-matched healthy controls.
Spatiotemporal deposition of hADSCs differed between young and aged rats , most notably reduced migration to the aged spleen.
Spatiotemporal gait data were obtained as participants completed two walks across a @number@.6-m electronic walkway ( GAITRite ( ® ) ) .
Spatiotemporal gait variables , average values and co-efficient of variation ( COV ) were obtained from @number@ consecutive steps during single- and dual-task walk trials.
Speakers respond automatically and rapidly to compensate for brief perturbations of pitch in their auditory feedback.
Speaking slowly and providing contextual information enhance patient comprehension.
Spearman correlation coefficients were calculated to examine the association between self-reported time and objective sedentary time.
Spearman correlation coefficients were examined between these motivation scores and symptom ratings.
Spearman correlation coefficient tests and Lin's concordance tests were applied to assess the absolute and relative association between the markers and mitochondrial content or OXPHOS.
Spearman correlations were used to associate autotaxin and CSF biomarkers due to non-normality.
Spearman rank order correlations were used to evaluate the correlation between the HAP scores and accelerometer variables.
Spearman's Correlation Coefficient and ANOVA were used to analyze the variables.
Spearman's correlations were calculated and were subjected to factor analysis.
Spearman's correlations were performed to examine relationships between gene expression patterns and hormone concentrations.
Spearman's correlation was used for comparison of strength of correlation.
Spearman's rank correlation coefficients for IVD and EP scores showed good consistency in predicting macroscopic degeneration.
Spearman's rank correlation with bootstrap resampling was used to find associations between parameters.
Spearman's rank-order correlations and ordinal logistic regression examined religious / spiritual variables as predictors of preferences for inclusion of religion or spirituality into counseling.
Spearman's rho was used to examine correlations between MRI volumes and neuropathology measures and linear regression to assess the relationship between neuropathology and MRI volumes.
Spearman's rho was used to examine the relationships with time of onset.
Spearman ρ correlations were used to assess the strength of the relationship between health literacy level and self-care scores.
Special attention has been paid to determining whether antidiabetic agents might be effective in treating AD.
Special attention is drawn to caffeine physiological effect on human organism.
Special attention is given to fertility-sparing treatments , due to the increasing number of older men desiring fatherhood.
Special attention is given to generation of reactive oxygen species ( ROS ) in various cellular compartments of cells under stress conditions inducing autophagy.
Special attention is given to methodological aspects of determination of activity of poly ( ADP-ribose ) polymerases ( PARPs ) .
Special attention is given to papers on foot deformities at initial stages of the disease.
Special attention is given to the analysis of the use of peptide bioregulators as geroprotectors.
Special attention is given to the influence of the cell proliferative status on PARP activity.
Special attention is given to the prospects of gerontology in Russia.
Special attention should be given to interventions to reduce the risk of falls , especially among older women.
Special attention should be paid to undiagnosed and insulin-dependent diabetes cases , which have a particularly high risk of poor cognitive performance.
Special attention was given to patients with dementia and delirium.
Special caution should be taken to the old population in hospitalized patients to prevent the pre-renal AKI.
Special disorders of life functions in elderly people are provided by cleft palate.
Special focus has to be placed on preoperative evaluation , the ventilation regime and general intraoperative management.
Special focus is dedicated to the contribution of optimal cognitive abilities to this success and to what extent MBI may support cognitive reserve.
Special focus is given to skeletal muscle and physical function.
Special focus is on catecholamines , peptides and other biologically active compounds acting in these processes.
Special focus will be on technologies with a potential to circumvent the problems associated with cell heterogeneity in biomarker discovery.
Specialist recommendation to cease or reduce dosage of these medications was associated with a high success rate.
Specialists claimed that they diagnose patients with AD themselves in @percent@ of cases versus @percent@ for generalists ( P < @number@ ) .
Specialized magnetic resonance imaging techniques are explored for diagnosing preclinical changes in white matter integrity or brain microvascular pulsatility.
Specialized receptors ( RAGE , Galectin 3… ) bind AGE.
Specialized training in geriatrics is essential for healthcare professionals to provide optimal health care.
Specializing and developing standards for determining the criminal responsibility of the elderly is required.
Special micro-anatomical features of the ITA wall may protect it from age related pathological changes.
Special operations are so designated for the specialized military missions they address.
Special scoring of word-list recall data for serial position has been suggested to improve discrimination of normal aging from dementia.
Special study rats in the @number@ g / kg groups died by the end of the first week.
Species are defined by biological criteria.
Species-specific lifespan , age-dependent changes in expression pattern of genes , etc. are compatible with the concept of phenoptosis.
Species such as naked mole rat , human and certain bat species all exhibit extreme longevity with respect to body size.
Specific action projects were implemented and evaluated to enhance these processes necessary for compassionate caring.
Specific actions are undertaken to optimize implementation of the Coach2Move strategy during the trial.
Specific age differences were found at stair transition where older adults showed more attentional effects.
Specific age-related populations ( i.e. , the very young and the aging athlete ) carry additional considerations.
Specific aim of this approach was to facilitate the design of future personalized preventive interventions in older persons.
Specific alcoholic beverage types were not associated with male breast cancer.
Specifically , after adapting to younger or older faces , faces of all ages appeared @number@ to @number@ years older or younger , respectively.
Specifically , ageing is defined as a time-dependent decline of functional capacity and stress resistance , associated with increased chance of morbidity and mortality.
Specifically , ageing presents peculiar epigenetic markers that , taken altogether , form the still ill-defined \ "ageing epigenome \ ".
Specifically , alterations in hormonal networks and concomitant hormonal deficits / excess , augmented by poor sensitivity of tissues to their action , take place.
Specifically , a ( MoM ) increase in maternal E3 concentration during early pregnancy was associated with a @time@ % increase in infant TL.
Specifically , a narrower spectral distribution with more long-range correlations and an inverted-U pattern of complexity changes were observed with increasing force level.
Specifically , antiretroviral NRTIs cause mitochondrial dysfunction , oxidative stress , and mitochondrial DNA defects that resemble features of both HANA and aging.
Specifically , a number of models will be showcased which focus on the complex age-related disorders associated with unhealthy aging.
Specifically , a significant increase in IGF-induced AKT phosphorylation and alkaline phosphatase ( ALP ) activity were observed in hMSC-TERT.
Specifically , a significant rise in coresidential living follows widowhood as well as deterioration in functional health.
Specifically , a smaller percentage of children with ASD showed face-sensitive activation of the FFA than TD children.
Specifically , at a high tangible support level , females had lower life satisfaction when compared to a low tangible support level.
Specifically , ATP and pH levels decrease as metabolic end products , oxidative stress , cytokines , and cell-free hemoglobin increase.
Specifically , because of predominant age-related changes in the hippocampus , we expected to find larger age differences in recognition of between-domain than within-domain associations.
Specifically , both spatial and temporal smoothness are imposed in the energy function to obtain consistent longitudinal sulcal parcellation results.
Specifically cardiovascular disease , certain cancers , and renal disease are more common with other comorbidities less certain.
Specifically , circRNA 103829 , circRNA 103827 and circRNA 104816 were validated to be up-regulated , while circRNA 101889 was down-regulated in AA samples.
Specifically , directed differentiation of HGPS-iPSCs to SMCs leads to the appearance of premature senescence phenotypes associated with vascular ageing.
Specifically , egg production and sexual harassment of females by males reduce female longevity.
Specifically , enhancing endogenous glutamatergic synaptic transmission through increased co-agonist signaling or through positive allosteric modulation of metabotropic glutamatergic receptors appears as an attractive strategy.
Specifically excluded were studies of psychotropic medications such as antidepressants , benzodiazepines , anxiolytics , hypnotics , mood stabilizers , and stimulants.
Specifically , five genes were not covered at all in the German data.
Specifically for dual-X-ray absorptiometry , prevalence ranged from @percent@ to @percent@ in men and from @percent@ to @percent@ in women.
Specifically , greater current L2 experience facilitated L2 word processing , but impeded L1 word processing among younger adults only.
Specifically , greater peak force error was associated with greater power from 13-30 Hz and lesser power from 30-60 Hz.
Specifically , HDAC3 stabilized ataxin-7 and increased modification of the protein.
Specifically , IGF-1 increases progenitor cell proliferation and numbers of new neurons , oligodendrocytes , and blood vessels in the dentate gyrus of the hippocampus.
Specifically , immune cell entry was largely considered to be pathological or to mark the beginning of pathology within the brain.
Specifically , increasing the sarcopenia , the relationship adiposity-osteoporosis ( β : @number@ ) decrease in intensity.
Specifically , individuals with low education but high self-efficacy performed similarly to individuals with high education.
Specifically , infants look longer at a negative emotional display when it follows a completed goal compared to when it follows a failed goal.
Specifically , interference is smaller both for individuals with higher working memory capacity and following an incongruent trial.
Specifically , it has been found that SIRT3 promotes activities of the upstream mitochondrial regulators adenosine monophosphate-activated protein kinase and PGC1α.
Specifically , it increased annually at @percent@ for age group @number@ - @number@ year versus @percent@ for age group @number@ years or more.
Specifically , it is unknown if greater anxiety leads to subsequent declines in cognitive performance or if worse cognitive performance leads to increased anxiety.
Specifically , it is unknown why elderly patients are more likely to develop POCD and whether POCD is dependent on general anesthesia.
Specifically , life-long physical activity and endurance exercise training have been proven to provide cardioprotection against cardiac insults in both young and old animals.
Specifically , likelihood ratio , Wald , and score tests are proposed and investigated.
Specifically , living with a spouse , financial independence , perceiving care support from any resource is associated with higher survival rates for elderly people.
Specifically , mean fragmentation was higher in the youngest age group than all other age groups , which did not differ from one another.
Specifically , minichromosome maintenance ( MCM ) helicase proteins are less abundant with age and SSc , and they exhibit an altered subcellular distribution.
Specifically , molecular aging was remarkably conserved across cohorts and brain areas , and included numerous developmental and transcription-regulator genes.
Specifically , more participants with atypically high postural sway pre-intervention experienced an overall postural sway reduction.
Specifically , older participants had problems integrating face features into global structures , demonstrating enhanced dependence on distal global information.
Specifically , @percent@ of patients reported pain ( @percent@ confidence interval 61%-67% ) and @percent@ reported weakness ( @percent@ confidence interval 75%-81% ) .
Specifically , PINK1 and parkin modulate mitochondrial dynamics by promoting autophagic removal of depolarized mitochondria.
Specifically , previous research has shown adolescents to be more , less , and similarly sensitive to alcohol-induced cognitive deficits compared to adults.
Specifically , regional primacy score ( a measure of word-list position learning ) most consistently predicted conversion to AD dementia and course of cognitive functioning.
Specifically , relative risks of outcomes associated with individual slopes in ( i.e. rate of ) dysregulation range @number@ @date@ per unit slope.
Specifically , responder rates at both maximum frown and at rest were assessed based on clinical photography.
Specifically , sex hormone actions during early development may confer inherent vulnerability of the female brain to development of AD in advanced age.
Specifically , SFN enhances progerin clearance by autophagy and reverses the phenotypic changes that are the hallmarks of HGPS.
Specifically , SFN-induced expression of heat shock protein @number@ ( Hsp27 ) underlies SFN-stimulated proteasome activity.
Specifically , social support had no significant impact on executing a will for either WPW or WPM.
Specifically , the abundance and signaling of the primary 5-HT receptor influencing appetite via POMC activation , the 5-HT2CR , is not perturbed with age.
Specifically , the aim of this study is to investigate the relationship between age-stereotypes and health locus of control.
Specifically , the Barcelona track was chosen because of its inherently difficult nature characterised by intermittent deceleration points.
Specifically , the cognitive reserve hypothesis is that individual differences in how tasks are processed provide reserve against brain pathology.
Specifically , the highest level of depressive symptoms was found among the underweight , followed by the severely obese and then the obese.
Specifically , the increase in their usage of ICT could be expected in leisure-based online activities.
Specifically , the influence of the cell cycle on γH2AX foci patterns is demonstrated in normal fibroblasts of the cell line NHDF.
Specifically , the latter group had lower modularity and small-worldness ( indices of more efficient network organization ) .
Specifically , the MDMX C-terminal ring domain binds to the RB C-pocket and enhances MDM2-RB interaction.
Specifically , the more active groups differed from controls , and in some cases from the least active group.
Specifically , the most frequent strategies used by older participants included submovements , while those used by young participants did not include submovements.
Specifically , the most significant associated SNP is located @number@ kb upstream of Fscn2.
Specifically , the Otago Exercise Program has demonstrated benefit and cost-effectiveness for the primary prevention of falls in four randomized trials of community-dwelling seniors.
Specifically , there is a clear contradiction between what the law recognizes as being a citizen's rights and the implementation of guidelines.
Specifically , the relationship between the biceps femoris muscle and the voluntary COP shift was reinforced in the elderly group.
Specifically , these challenges will include volume and financial management , as well coordination of cancer treatment and pain management.
Specifically , these studies identified rigidity in place cell remapping in similar environments in the CA3.
Specifically , the signaling mediated by cytokines and hormones secreted by TECs declines during aging.
Specifically , the similar hypoestrogenic hormonal milieu present during postpartum lactation provides biologic advantages ( fitness ) to both mother and newborn.
Specifically , the uncinate fasciculus is the major direct fiber tract that connects the prefrontal cortex and the amygdala.
Specifically , they exhibit deficits in naming and repetition in the context of spared semantic , syntactic , and motor speech abilities.
Specifically , they reached to grasp cylinders located at near and far positions in either unimanual or bimanual condition.
Specifically , thiazides and calcium channel blockers have been known to cause itch in elderly patients.
Specifically , TMS can measure cortical excitability , intracortical inhibitory and excitatory mechanisms , and local and network cortical plasticity.
Specifically , using this cut-off value , total IgA deficiency could be excluded with a sensitivity of @number@ and specificity of @number@
Specifically , we adapted a well-established discounting paradigm to measure the extent to which cognitive effort causes participants to discount monetary rewards.
Specifically , we analyzed reduced inflammation and improved metabolic profile as a potential medium through which the MeDi reduced the risk of AD.
Specifically , we argue that damage to the auditory system generates an initial tinnitus signal , consistent with previous research.
Specifically , we ask whether additional children improve or threaten parents ' mental health status.
Specifically , we conducted a longitudinal study of alterations in face shape induced by aging.
Specifically , we considered twin correlation ratios to agnostically re-evaluate biometrical models across age and by cognitive domain.
Specifically , we consider streamlines from different subjects as data streams , and each streamline is assigned to a mobile agent.
Specifically , we describe evidence showing that these forgotten early-acquired memories have not permanently decayed from storage.
Specifically , we employed five different delays ( @number@ s-1.1 s ) between masker onset and target speech onset.
Specifically , we examine how childhood identities were shaped in three settings ; home , hospital and school.
Specifically , we examine whether APOE ε4 moderates the association between high blood pressure and cognition in later life.
Specifically , we explore this dichotomy in the context of societal understandings and responses to dementia.
Specifically we find that @number@ ESTs are differentially regulated in mature and old R15 neurons.
Specifically , we focus on the heritability of brain structures across the ages , age-related genetic influences on brain development and sex-specific developmental trajectories.
Specifically , we follow drebrin-connexin-43 interactions and drebrin behavior at the cell-cell interface described earlier.
Specifically , we have little knowledge regarding the role mTOCR1 has in liver physiology.
Specifically , we hypothesized that age-related deficits in neural synchrony and neuronal oscillatory activity occur independently in older adults and disrupt auditory temporal processing.
Specifically , we identified differences in tau strain potency between AD-tau , CBD-tau , and PSP-tau in non-Tg mice.
Specifically , we identify REST and regulatory factors of the histone methyltransferase MLL complex , whose function may be disrupted in aging.
Specifically , we propose that parents influence RAEs through Matthew effects , coaches influence RAEs through Pygmalion effects and athletes influence RAEs through Galatea effects.
Specifically , we review data on ovarian and nonovarian reproductive aging processes and reproductive staging.
Specifically , we speculate about possible pathomechanisms underlying nesprin-associated diseases.
Specifically , we tested whether priming was equivalently sensitive in both age groups to reversal of the task-specific decision cue.
Specifically , we will show that the HyperSPHARM basis forms a subset of a wavelet-based multiscale representation of surface-based signals.
Specifically within those with type @number@ DM , greater glycemic variability in GVC2-3 was associated with worse learning and memory scores.
Specifically , zebrafish β2aAR had a high binding affinity for phenylephrine , a classical α-adrenergic receptor agonist.
Specifically , α-synuclein directly bound to the SNARE-protein synaptobrevin-2 / vesicle-associated membrane protein @number@ ( VAMP2 ) and promoted SNARE-complex assembly.
Specific antibody titers against influenza virus and CMV were determined by ELISA.
Specific aspects of power analysis for pharmacoeconomic studies are presented.
Specific associations with vertebral fracture ( n = @number@ ) , and nonvertebral fracture ( n = @number@ ) were also computed.
Specific attention is paid to issues relating to inappropriate or suboptimal antibiotic prescribing to guide future AMS interventions.
Specific bile acids are potent signaling molecules that modulate metabolic pathways affecting lipid , glucose and bile acid homeostasis , and the microbiota.
Specific biomolecular interactions for each antioxidant also will be important.
Specific challenges such as delirium , functional decline , or carer strain need to be screened for and managed appropriately.
Specific clinical and early anatomical features may suggest rare and atypical pathological diagnosis in vivo.
Specific clinical settings are also detailed , such as the Ramadan or multiple medications especially in elderly patients.
Specific clusters of metabolic syndrome ( MetS ) components impact differentially on arterial stiffness , indexed as pulse wave velocity ( PWV ) .
Specific cohorts that account for most of the disparity in mortality between the populations are identified.
Specific cohorts were created to identify osteoporosis-related fractures and their costs.
Specific consideration was given as to how these two spheres intersect in regard to recall and memory.
Specific contributions by poor bottom-up and or top-down control of visual attention to the reduced FFOV of older adults were investigated.
Specific diagnoses like stroke , dementia and cardiac disease were not related to LS.
Specific dietary patterns , like the Mediterranean diet , may be more beneficial than a high consumption of single nutrients or specific food items.
Specific diets such as the Mediterranean diet rich in anti-oxidants , is currently investigated in the prevention of frailty.
Specific drug classes are associated with increased rates of kidney injury including agents that block the renin angiotensin system , antimicrobials , and chemotherapeutic agents.
Specific examples of such foods are apples , pears , graapes , wine , and tea.
Specific examples of the bioimaging of metal distributions in normal rodent brains are provided.
Specific facial findings often help point to the correct diagnosis , which improves counseling and management.
Specific factors for example falls , hip axis length , vertebral fracture assessment could be used in individual patients.
Specific factors of cognitive failures were differentially associated with measures of depression and working memory.
Specific food preferences in participants with a poor appetite were identified by one-sample t-tests comparing frequencies to the expected value of @number@
Specific force and maximum shortening velocity ( Vo ) were measured with single muscle fibres.
Specific genes are responsible for the control of oocyte number undergoing the ovulation process and the time to cessation of the reproductive function.
Specific inhibition of the UBC13-UEV1A complex responsible for K63-linked ubiquitination establishes Lys147 as the predominant site of K63-ubiquitin conjugation and responsible for STAT3 activation.
Specific interventions for OLT recipients should be designed to evaluate and change their health perceptions and encourage their return to work.
Specific interventions , such as Dignity Therapy and advance care planning , may aid this state of mind.
Specificitiesare linked to the existence of HIV-specific risk factors and to the problem of drug-drug interactions with antiretrovirals.
Specificity and positive predictive value were low ( ≤33% and ≤24% , respectively ) .
Specificity and positive predictive value were low ( ≤45% and ≤27% , respectively ) .
Specificity and sensitivity were used to evaluate the accuracy of the detection algorithms.
Specificity for CAA was decreased using the Condensed Protocol when compared with the Original Protocol.
Specificity of informant-derived lifetime mood disorder diagnoses was compromised by lower Agreeableness and higher Conscientiousness.
Specificity of the tests to detect MCI was similar.
Specific memory functions seem unimportant , except for procedural memory.
Specific microbial genera were differentially abundant in the lower , middle , and upper 33rd percentiles of biological age.
Specific mobility and balance interventions reduce falls risk.
Specific molecular pathways detect misfolded proteins and act either to unfold or degrade them.
Specific obstacles encountered in caring for these patients are discussed.
Specific patterns were identified in chronic diseases , disease comorbidity , and disability rates.
Specific policies examined in this paper concern medical reporting and medical review , license renewal processes , and driver testing.
Specific protocols were designed to test the compatibility of this new electrode material , both with EMG recording and with US analysis.
Specific psychiatric features have not yet been clarified , specifically in relationship to age and genetic characteristics.
Specific recommendations regarding antiretroviral treatment of older HIV-infected individuals are lacking and prospective trials in older age groups are urgently needed.
Specific recruitment efforts are also directed at subjects with Alzheimer's disease , Parkinson's disease and cancer.
Specific screening and treatment of spatial neglect during acute stroke care may be necessary to improve long-term mobility recovery.
Specific sequence alterations within the homozygous regions identified by whole exome sequencing were verified by Sanger sequencing.
Specific strategies are presented that have been successfully implemented to improve recruitment and retention in research targeting minority older adults.
Specific studies on the incidence and prevalence of sarcoidosis in this subgroup are scarce.
Specific subregion diffusivity measures may be a more sensitive aging marker than hippocampal volume change.
Specific system-based alterations , such as the coagulopathy observed in sepsis , offer both potential insight and possible therapeutic targets.
Specific target IOIs within sequences differed across discrimination conditions.
Specific topics have been selected to illustrate the principles of important paradigm shifts that will influence the future of ophthalmic diagnostics.
Specific to these conditions are assessments of cognition , neuropsychiatric symptoms , and level of functioning.
Specific variations of VEGF genes have been demonstrated to be genetic determinants for susceptibility , outcome and therapy response , especially for the solid tumors.
Specific YY1 siRNA led to decreases in APH-1A promoter activity and mRNA and protein levels.
Specifying different types of reminiscence is a crucial component of the approach.
Specify strategies to reduce falls in older adults , especially as related to maintaining skin integrity.
Specimen aging enhanced the surface phase changes and also induced compressive stresses in zirconia polished with Intensiv.
Specimens aged @number@ years or older , of either sex , and of any race were considered for this study.
Specimens ( @date@ @date@ mm ) were produced and stored in water for @number@ h , or @number@ months in either water or mineral oil.
Specimens from black individuals had larger width and height , as well as steeper slope.
Specimens from both upper eyelids then underwent histologic examination using light and transmission electron microscopy.
Specimens from each material were tested after aging with Red Bull , Bison and Power Horse energy drinks and distilled water as a control.
Specimens ( @number@ mm thick , @number@ mm diameter ) were divided into eight groups of @number@ specimens per group.
Specimens of coronal dentin were evaluated by nanoDMA using single indents and in scanning mode via scanning probe microscopy.
Specimen-specific finite element models of the posterior scleras were generated from the experimentally measured geometry.
Specimen-specific intertrochanteric fractures were induced by subjecting the femur models to a sideways fall and repaired with a contemporary implant.
Specimens produced for mechanical properties evaluation were also analyzed before and after the 60-day intra-oral aging.
Specimens stored in PA and DW showed bond strengths significantly reduced after one and six months , respectively ( p < 0.05 ) .
Specimens were aged @number@ to @number@ years.
Specimens were carried out using layering with different shades of composite , and dental blocks ( dentin / enamel ) were obtained of human molars.
Specimens were dissected in a layered fashion to analyze relationships between the injected filler and midfacial anatomy.
Specimens were either auto-polymerized or dual-cured ( except P21 ) and stored in water at @number@ °C for @number@ day prior to measurement.
Specimens were evaluated at @number@ h , after application of the surface sealant Fortify Plus , and after thermocycling.
Specimens were fixed in formalin and embedded in paraffin.
Specimens were individually tested for biaxial flexure on a universal testing machine.
Specimens were loaded to failure in a universal testing machine , and the data were analyzed with 2-way ANOVA ( α = .05 ) .
Specimens were sectioned in beams , which were tested ( μTBS ) immediately or after @number@ months of aging.
Specimens were sectioned into sticks and subjected to microtensile testing.
Specimens were sections into beams and the μTBS was tested.
Specimens were sliced into sticks ( @number@ ± @number@ mm2 ) for microtensile bond strength testing ( μTBS ) .
Specimens were stored at 37°C in dark containers for @number@ @number@ @number@ and @number@ days.
Specimens without failures during TCML were loaded until failure.
Specimen workup , histomorphological analysis and immunohistochemical analysis were performed in a standardized manner.
Spectacle , contact lens , and aging influences were evaluated.
SPECT images were analyzed by Statistical Parametric Mapping ( SPM5 ) .
Spectral analysis of wake electroencephalogram ( EEG ) was performed for 30-second periods at the start of each MSLT trial.
Spectral data were processed and interpreted by exploratory unsupervised chemometric methods based on hierarchical cluster analysis and principal component analysis.
Spectral domain optical coherence tomography was used to identify foveal bulge.
Spectralis HRA + OCT was used to scan a circular region around the optic disc.
Spectrographic analysis of temporal and acoustic characteristics was carried out using the Praat software.
Spectroscopical analysis and melting temperature studies suggest structural perturbations in the DNA as a result of modification.
Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells.
Spectroscopic studies revealed structural alterations in the DNA molecule upon crotonaldehyde treatment which result in the generation of neoepitopes and enhanced immunogenicity.
SPECT was repeated @number@ to @number@ months after the acute event in @number@ patients.
Speech comprehension in multitalker situations is a notorious real-life challenge , particularly for older listeners.
Speeches were transcribed and analyzed with Linguistic Inquiry and Word Count software and coded for interpersonal content.
Speech is slowed because of expiratory strength effort.
Speech is unique among highly skilled human behaviors in its ease of acquisition by virtually all individuals who have normal hearing and cognitive ability.
Speech perception by the older group was enhanced , and the enhancement effect was similar to that observed with the younger group.
Speech perception difficulties are common among elderlies ; yet the underlying neural mechanisms are still poorly understood.
Speech perception in background noise is a common challenge across individuals and health conditions ( e.g. , hearing impairment , aging , etc. ) .
Speech perception in multitalker environments often requires listeners to divide attention among several concurrent talkers before focusing on one talker with pertinent information.
Speech perception tests showed statistically significant improvement in speech recognition.
Speech understanding in the presence of concurring sound is a major challenge especially for older persons.
Speech understanding performance in the presence of a steady-state masker was related to high-frequency pure-tone thresholds.
Speed did not differ between the groups.
Speed discrimination thresholds were determined using a staircase procedure.
Speed of error correction was estimated from the number of tones to return within @percent@ of the preshift synchronization error.
Speed of onset was extracted as either the interval between symptom onset and diagnosis or between hospital admission and diagnosis of incident delirium.
Speed of processing training has been shown to improve cognitive functioning in normal older adults.
Speed of processing was found to be the best predictor of performance , rather than the efficiency of EF or semantic knowledge.
Speed related profiles of peak HCFs and ground reaction forces ( GRFs ) reveal a different progression of the two peaks during walking.
Speed was reduced under all loaded conditions , with a greater effect in young than older participants when handling a stroller or shopping cart.
Spent POS are eliminated daily by RPE cells.
Spermatogonial stem cells ( SSCs ) are germline stem cells located along the basement membrane of seminiferous tubules in testes.
Sperm CFTR expression was conducted by indirect immunofluorescence staining.
Sperm chromatin integrity was measured by sperm chromatin structure assay.
Sperm concentration ( normospermia , oligozoospermia , and azoospermia ) is not well associated with hypoandrogenism in infertile men.
Sperm concentration , sperm motility , and normal head morphology were negatively correlated with the amount of CpG methylation.
Sperm concentration , total count and progressive motility were analysed by computer-assisted sperm analysis.
Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes.
Spermidine's mechanism of action on aging has been primarily related to general protein hypoacetylation that subsequently induces autophagy.
Sperm immunofluorescence quantification experiments disclosed whether the aged men indeed shared the same PATE1 defect with @number@ young asthenozoospermia patients.
Sperm morphology was analysed by modified Papanicolaou staining.
Sperm quality declines with aging ; however , the underlying molecular mechanism remains elusive.
Sperm quality was assessed by motility and bicarbonate-induced capacitation.
Sperm selected from the @percent@ gradient fraction exhibited less methylation than sperm from the @percent@ fraction.
Spherical equivalent anisometropia changed from @number@ to @percent@.
Spherulation degree is considered as biological age and along with the volume determines the probability of their elimination from circulating bed.
Sphingolipid levels are tightly regulated to maintain cellular homeostasis.
Sphingolipid microdomains , also called lipid rafts , participate in several metabolic and catabolic cell processes , including apoptosis.
Sphingolipids are components of all eukaryotic cells that play important roles in a wide variety of biological processes.
Sphingomyelin metabolism has been linked to several diseases and to longevity.
Sphingosine kinase , the enzyme that synthesizes S1P , is a crucial enzyme in regulation of the balance of these sphingolipids.
SP-HSC in blood and bone marrow decreased with age but the quality of the surviving stem cells increased.
SPI1 encodes PU.1 , a transcription factor critical for myeloid cell development and function.
Spinal cord injury ( SCI ) causes profound bone loss due to muscle paralysis resulting in the inability to walk.
Spinal cord injury ( SCI ) due to tumors accounts for 26-45% of non-traumatic SCI.
Spinal cord regeneration is very inefficient in humans , causing paraplegia and quadriplegia.
Spinal muscular atrophy results from diminished levels of survival motor neuron ( SMN ) protein in spinal motor neurons.
Spinal stenosis is an abnormal narrowing of the spinal canal that mainly occurs in the cervical and lumbar regions.
Spindle peak frequency was negatively related to full scale IQ ( r = @number@ ) .
Spine and femoral BMD ( both total hip and neck ) were positively correlated with body weight.
Spine disorders in patients with PD may be degenerative in nature or may arise secondary to motor effects related to the parkinsonian disease process.
Spine protection was blocked by neuronal deletion of S1R.
Spine specialists performed computer-based measurements.
Spine specialists performed lumbar disc degeneration evaluations through the Pfirrmann's classification system.
Spines , the postsynaptic elements , are morphologically the most plastic part of the synapse.
Spine strength depends primarily on the number of incorporated glutamatergic receptors , which are more numerous in larger spines.
Spin exercise also resulted in a significant improvement in estimated V02max ( P = @number@ ) .
Spin exercise can be an effective mode of aerobic exercise to improve semantic fluency in previously sedentary older adults.
Spinocerebellar ataxia ( SCA ) is a clinically , pathologically , and genetically heterogeneous group of dominantly inherited neurodegenerative disorders.
Spinocerebellar ataxia type @number@ ( SCA7 ) is caused by a toxic polyglutamine ( polyQ ) expansion in the N-terminus of the protein ataxin-7.
Spiral scores were higher in boys than girls , were inversely associated with age , and were higher in the nondominant than dominant hand.
Spiral scores were highest in children who were taking psychiatric medications and in children with psychiatric or neurological disorders.
Spiral score was correlated with age ( r = @number@ P = @number@ ) .
Spiritual issues often come to the fore.
Spirituality had a direct negative relationship with severity of depression , while relationship of spirituality with severity of cognitive decline was more complex.
Spirituality is another important dimension in elderly , and it is believed to help them cope with various adversities.
Spirituality's influence on general well-being and its association with healthy ageing has been studied extensively.
Spirituality was the highest in controls , followed by MCI group , and then depression group.
Spiritual / religious identity was marginally associated with insurance status for men aged 36-50.
Spiroergometry is well established in occupational and social medicine.
Spirometric obstruction is a prevalent problem in older adults and related to life-style risk factors.
Spirometric obstruction prevalences were @number@ and @percent@ with fixed and age-corrected FEV1 / FVC thresholds , respectively.
Spirometry can guide therapies for COPD and predict outcomes when used in general practice.
Spironolactone significantly reduced systolic and diastolic BP at rest and peak exercise.
Splanchnic sequestration can be saturated by pulse feeding ( @percent@ of daily protein intake in a single meal ) , enabling increased protein synthesis.
Splenic T cells were harvested using anti-CD3 Dynabead isolation.
Spline functions demonstrated a difference between 25 ( OH ) D deficient and sufficient individuals.
Spline models indicated that dynamic associations between memory and functional limitations were substantively similar between participants aged 70-79 and those aged 80-95.
Splines were used to graphically present behavior-mortality relation.
Split-face design comparing a monophase hyaluronic acid ( HA ) filler ( mono-HA ) with a biphasic HA filler ( bi-HA ) .
Split-read analysis of WES data followed by breakpoint PCR and Sanger sequencing determined both breakpoints flanked by a 4-bp microhomology ( CTTG ) .
SPMs were analyzed in cerebrospinal fluid ( CSF ) .
SPN was defined as peripheral neuropathy and bilateral symptoms.
Spoken number words of two speakers were presented simultaneously to participants from two out of eight locations on the horizontal plane.
Spondylometaphyseal dysplasia Kozlowski type ( SMDK ) is a monogenic disorder within the TRPV4 dysplasia spectrum and has characteristic spinal and metaphyseal changes.
Spontaneous adoption of new models of care is unlikely without specific attention to the complexities and resource constraints of health care systems.
Spontaneous clearance was defined as undetectable viremia twice at least 6-months apart.
Spontaneous coronary artery dissection ( SCAD ) is a rare cause of acute myocardial infarction and sudden cardiac death.
Spontaneous EI and protein intake also declined over time and were higher in the years preceding menopause onset ( P < 0.05 ) .
Spontaneous home visits were appreciated by some , but rejected by others.
Spontaneous or environmental neurotoxin-mediated exacerbation of these processes contributes to the symptoms of AD and PD , respectively.
Spontaneous recognition was measured as the influence of old vs. new distracters on target recognition.
Spontaneous retrieval was inferred from slowed lexical decision responses to target cues ( i.e. , intention interference ) .
Spontaneous rupture of the Achilles tendon is increasingly common in the middle aged population.
Sporadic amyloid β-protein ( Aβ ) -type CAA is commonly found in elderly individuals and patients with Alzheimer disease.
Sporadic amyotrophic lateral sclerosis ( sALS ) is a severe neurodegenerative disease that causes progressive motor neuron death.
Sporadic and hereditary microphthalmos have been associated with heterozygous mutations in genes fundamental for eye development.
Sporadic Creutzfeldt-Jakob disease is considered primarily a disease of grey matter , although the extent of white matter involvement has not been well described.
Sporadic inclusion body myositis ( IBM ) is an acquired muscle disorder associated with ageing , for which there is no effective treatment.
Sporadic inclusion body myositis ( sIBM ) is an intractable and progressive skeletal muscle disease of unknown etiology and without effective treatment.
Sporadic inclusion body myositis ( sIBM ) is the most common acquired muscle disease in older individuals.
Sporadic inclusion body myositis ( sIBM ) is the most frequently acquired myopathy in patients over @number@ years of age.
Sporadic tauopathies are characterized by differential cellular and topographical predominance of phospho-tau immunoreactivity and biochemical distinction of the tau protein.
Sport-related concussion ( SRC ) is a common mild traumatic brain injury among young , active individuals , affecting approximately @number@ young American adults annually.
Sports and weight-bearing activities can have a positive effect on bone health in the growing , mature , or aging athlete.
Sports clubs accessible to older people may improve health in this demographic by increasing activity levels and reducing frailty and associated comorbidities.
Sports-related orbital fractures are the fourth most common cause of orbital fractures.
Sports specific training , realistic goal setting , and counseling are of maximal importance.
Spot and 24-hour urine samples are collected in a random subsample ( n = 1200 ) and sodium , potassium , creatinine and iodine analysed.
Spousal caregiving allows stressed couples to continue living in the community rather than seeking institutional solutions.
Spousal caregiving is associated with a @percent@ increase in the likelihood of experiencing difficulties in meeting basic expenses compared to other types of caregiving.
Spousal driving cessation reduced husbands ' likelihood of working or formal volunteering , and wives ' likelihood of working or informal volunteering.
Spouse caregivers report more depression symptoms , greater financial and physical burden , and lower levels of psychological well-being.
Spouse education moderated the relationship between years since spouse's retirement and SRH for wives.
Spouses also had lower income , more social transfer , and posed higher health-related costs than matched controls.
Spouses provide the majority of care for individuals with Alzheimer's disease ( AD ) .
Spouses were also exposed to psychological threats , physical violence , and had feelings of placing one's own needs last.
SPP1 expression was especially reduced in surviving large neurons in both M1 and the spinal cord of ALS patients.
Sprague-Dawley male rats aged @number@ months were used in the experiment.
Spray use was lower in the West than in the Northeast ( @number@ [ @number@.58-0.97 ] ) .
Spread occurred within the home care context of high staff and manager turnover and time and resource constraints.
SPRTN accomplishes DPC processing through a unique DNA-induced protease activity , which is controlled by several sophisticated regulatory mechanisms.
SPRTN cleaves various DNA binding substrates during S-phase progression and thus protects proliferative cells from DPC toxicity.
SPS remained unchanged.
SPSS10.0 software was used for data and statistical analysis.
SPs share some risk factors with conventional adenomas and have been associated with tobacco use , obesity , and age.
SPSS @number@ software package was used for statistical analysis.
SPSS @number@ software was used to analyze the date.
SPSS @number@ ( SPSS Inc , Chicago , IL ) was used to analyze the data.
SPSS @number@ was used for statistical analysis.
SPSS version @number@ was used for descriptive analysis of participant characteristics and to determine frequencies of perceived outdoor fall risks and strategies used for prevention.
SPT was performed using an audio or video recording prepared by family members or surrogates.
Spurred by these positive findings in normal subjects , investigators have tried to determine if being bilingual may be associated with delayed onset of AD.
Sputum culture was applied to detect bacterial infection and quantitative ELISA was adopted to detect the specific antibodies of MP and CP.
Sputum fractionation had a relatively minor effect on the levels and AUC of these proteins.
Sputum levels of these proteins correlated inversely with obstruction and positively with ageing , smoking history , sputum macrophages and eosinophils.
Sputum samples were processed and then were analyzed by optical microscopy.
Sputum was collected in @number@ fractions ( @number@ periods of @number@ min each ) .
SPV should next be used to test patients with an impaired sense of verticality , to determine its diagnostic value in comparison to established tools.
SPY is significantly associated with an increased arterial stiffness in smokers regardless of gender , and with an increased SBPAo only in female smokers.
SQ-PCR of selected mtDNA sequences confirmed the potential of the extract to alleviate levels of mtDNA damage.
Square peripheral precues ( @number@ ms ) indicated likely target locations ( @percent@ valid ) across two or six locations ( set sizes ) .
Squatting , walking and climbing functions were affected significantly.
SRC correlated strongly with hemoglobin , vitamin E , BMI and serum ferritin.
SRCF might prove useful in improved risk stratification in primary prevention.
SRH did not predict toxicity or mortality.
SRH provides a simple assessment tool for identifying individuals at increased risk for decline in physical function.
SRH was assessed with a single-item question in the ACT study.
SRH was measured with the question \ "How is your health in general ? \ " including @number@ response categories.
SR rate also manifested significant variations ( from @number@ up to @number@ ) .
SR significantly inhibited oxidative damage and skin-aging factor via mitogen-activated protein kinase signaling pathways.
SRT1720 was initially described as an activator of human Sirt1 , but it also potently inhibits human Sirt3.
SS-31 binds selectively to cardiolipin via electrostatic and hydrophobic interactions.
SS-31 did not impact podocyte density , but it reduced markers of podocyte injury ( desmin ) and improved cytoskeletal integrity ( synaptopodin ) .
SS-31 is a member of the Szeto-Schiller ( SS ) peptides known to selectively target the inner mitochondrial membrane.
SS-31 represents a new class of compounds that can recharge the cellular powerhouse and restore bioenergetics.
SS-31 treatment improved age-related mitochondrial morphology and glomerulosclerosis.
S. sanguinis colonies from CF individuals produced significantly larger H2O2 halos compared with HC subjects.
S. sanguinis counts were significantly higher in CF than HC individuals ( p < 0.05 ) .
SSH1 also contains a DEK-C domain in the N-terminal region.
SSH1 binds to and co-localizes with F-actin , and the cofilin-phosphatase activity of SSH1 is markedly increased by binding to F-actin.
SSH1 is accumulated in the F-actin-rich lamellipodium but is also diffusely distributed in the cytoplasm.
SSH1 is bound to and activated by F-actin , but not G-actin.
SSH1 was activated by gelsolin-generated soluble actin filaments.
SS is often difficult to diagnose and may be life-threatening if not adequately managed.
SSNA was normalized to , and expressed as , a percentage of baseline.
SSRI use was associated with a higher risk of any nonspine fracture , but not hip fracture , in this cohort of older women.
SST expressing cells were detected by immunohistochemistry on colonic biopsy samples ( n1 = @number@ n2 = @number@ n3 = @number@ ) .
SST methylation percentage in biopsy samples ( n1 = @number@ n2 = @number@ n3 = @number@ ) was defined using methylation-sensitive restriction enzyme digestion.
SSTR1 is a member of the superfamily of somatostatin receptors possessing seven-transmembrane segments.
ST188 ( @percent@ ) was the most common sequence type regardless of classification.
Stability , change , and covariation were investigated in longitudinal biometric models.
Stability of p53 is regulated by the ubiquitin-proteasome pathway ( UPP ) .
Stability of the epoxide group was also studied under liquid chromatography-mass spectrometry ( LC-MS ) conditions.
Stability of the formulation was also monitored for @number@ months at multiple storage conditions per ICH Q1A ( R2 ) guidelines.
Stability performance has been examined by simulated forward falls before and after the intervention.
Stabilization of stalled DNA replication forks is a recently identified PARPi-resistance mechanism that promotes genomic stability in BRCA1 / 2-deficient cancers.
Stabilization solutions can now robustly preserve fresh tissue for up to 7days at room temperature.
Stabilometric measures appear useful in investigating the relationship between balance , sensory disturbance , and falls.
Stable and brightly luminescent amine-terminated Si nanoparticles ( SiNPs ) have been synthesized from electrochemically etched porous silicon ( PSi ) .
Stable angina was present in @percent@ of patients.
Stable fullerene nanoemulsions were formulated using high shear homogenization and ultrasonic dispersion technique.
Stable IFG did not show greater decline in global cognition or brain volumes compared to normal.
Stable isotope tracer methodology was applied to assess the basal as well as the postprandial muscle protein synthesis rates in the three groups.
Stable MiR-30a over-expression strongly impaired epidermal differentiation , inducing severe barrier function defects in an organotypic culture model.
Stable or at least limited weight gain may be a preventive factor.
Stable overexpression of TXS increased VEGF secretion in-vitro.
Stable skin replacement of severely burned patients have proven life saving.
Stably Expressed Genes ( SEGs ) whose expression varies within a narrow range may be involved in core cellular processes necessary for basic functions.
ST-activated OAs reported more TRI than ST-relieved OAs and had worse performance on the operation span task.
Staff and resident outcome measures were obtained pre-intervention , three months and six months post-intervention.
Staff education was the most cited opportunity for improving diabetes care.
Staff felt conflicted between their desire to provide optimal treatment for one ill resident , and their obligations to other residents under care.
Staff in the control group only received education on how to measure MNA and the residents followed the usual meal routines.
Staff ( n = @number@ ) and residents ( n = @number@ ) were from @number@ residential care facilities.
Staff participated in focus groups and received continuing education credit.
Staff perspectives were largely consistent with published data , but we describe new results for other informant groups.
Staff turnover may be an important barrier to improved LTC immunization rates.
Staff turnover was cited as a significant barrier to improved performance.
Staff workers used huddles as a forum to stay informed , review work , problem solve , and develop person-centered action plans.
Staged generalized additive models assessed the impact of caregiving on HRQoL and the role of caregiver strain and global stress in this relationship.
Staged stepwise multiple linear regression analyses were carried out for each of the four anger scores.
Stage @number@ and slow-wave sleep predicted worse and better sleep quality , respectively.
Stage of change progression may be enhanced using a goal-setting tool during strength training in older women.
Stages of reproductive aging were defined as premenopause , early postmenopause , and late postmenopause.
Stages of the model are illustrated by experiences within the context of retirement.
Stages were characterized using empirically defined methods.
Staining with hematoxylin and eosin was performed to evaluate collagen and fat composition.
Staining with propidium iodide ( PI ) followed by flow cytometry was used to detect cell cycle phase.
Stair ascent was assessed at self-chosen ( AFV ) , standardized ( ASV ) , and maximal velocity ( AMV ) pre- and posttraining.
Stakeholder engagement in genomics policy development is still at a nascent stage.
Stakeholder engagement is widely lauded as an important methodology for improving clinical , scientific , and public health policy decision making.
Stakeholder incongruence arises as a mismatch between the needs of the BSN program and the skills and contributions of aging nurse faculty members.
Stakeholder input is critical to guide the development and delivery of acceptable and useful child safety education.
Stakeholders and program planners can use these data to guide decisions regarding introducing telerehabilitation as a new service in their clinic.
Stakeholders are , however , somewhat pessimistic and many sense complete rebuilding , or major changes , may be necessary.
Stakeholders sought modules incorporating communication skills , cultural and social issues and the importance of a multidisciplinary approach to aged care.
Stakeholders were drawn from local government , and a range of community groups and organisations , as identified in a scoping study.
Stance knee co-contraction of non-fallers was similar to young for shorter steps and similar to fallers for longer steps.
Standard 12-lead ECG enabled measurement of QT and Tpeak-Tend ( TpTe ) intervals and TpTe / QT ratios.
Standard anticoagulation does not completely inhibit thrombin generation , and continuous consumption of coagulation factor continues throughout bypass.
Standard cancer treatments can be safe and effective in older adults and result in improved survival and enhanced quality of life.
Standard care consists of instructions for self-monitoring visual changes with subsequent self-report to the clinical center.
Standard care included regular home visits by social workers.
Standard chemotherapy often only provides these patients a few extra months survival time.
Standard criteria were used to classify 8-year incident dementia and subtypes.
Standard descriptive statistics as well as correlations were calculated and possible gender age influences tested for both populations separately.
Standard echocardiography operators were blinded on PSID exam and viceversa.
Standard face-lifting techniques are described , along with the authors ' preferred approach , supplemented by video demonstration of the high-superficial musculoaponeurotic system technique.
Standard first-line chemotherapy for younger patients with stage IV NSCLC includes platinum-combination therapy.
Standard instruments were used to evaluate SCD , episodic memory , BPS and affective states.
Standardization in outcome reporting was lacking , and clinical outcome data were absent.
Standardized administrator interviews provided facility level data.
Standardized blepharoplasty , which has often been improperly used , has shown its limits.
Standardized class II cavities were cut in @number@ human molars with one proximal box limited within enamel and one proximal box extending into dentin.
Standardized cognitive and neurological evaluations were repeated after @number@ @number@ and @number@ years.
Standardized diagnostic algorithms and rigorous perioperative assessment are critical to safe management of glaucoma patients undergoing refractive corneal surgery.
Standardized digital photographs in frontal view were captured with the forehead and eyebrows in a maximally relaxed position and with the eyes open.
Standardized digital photographs were taken and self-assessment questionnaires were conducted.
Standardized digital photography and subject self- assessment were performed at each visit.
Standardized education in healthcare core curriculum , reference guidance and training are strongly needed to improve elder abuse recognition in Italy.
Standardized effects were coded as positive when less fatigue was reported in older individuals compared with young individuals.
Standardized exercise programs do not necessarily bring about the behavioral change that is necessary.
Standardized exercise programs do not necessarily lead to more physical activity in daily life , however , and a more personalized approach seems appropriate.
Standardized field-based fitness tests were used to assess muscle strength ( 30-s chair stand , handgrip strength and arm curl tests ) .
Standardized mean differences ( SMDs ) were used for cognitive test scores in RCTs.
Standardized measures revealed that children's attitudes towards older adults improved , though not significantly so , after participation in the intergenerational program.
Standardized methods are used for case ascertainment and data recording by trained staff into standardized case report forms.
Standardized methods for prescribing and monitoring exercise intensity are needed to advance exercise research in Alzheimer's disease ( AD ) .
Standardized neuropsychological tests are valid predictors of later functional changes in both non-demented and demented older adults.
Standardized photographs using the Canfield Visia CR system® were assessed by two independent observers.
Standardized protocols were used to collect clinical and biochemistry data.
Standardized radiographs were sent to the coordinating centre for centralized evaluation in duplicate by two physicians who were blind to PPI status.
Standardizing the operational methods and evaluation of the single activities and a joint practice can contribute to achieve the validation of the application model.
Standard kaolin-activated thromboelastograms were then run with the primary outcome variable being estimated percent lysis.
Standard magnetic resonance imaging ( MRI ) fails to differentiate between pathologic painful and asymptomatic aging discs.
Standard magnetic resonance imaging ( MRI ) scans , vaMTA , and calculations of hippocampal volumes were performed in @number@ subjects.
Standard mean differences ( SMD ) or mean differences ( MD ) , and @percent@ confidence intervals ( CIs ) were calculated using random-effect models.
Standard observational studies of individual-level associations , however , are subject to potential confounding of exposure and outcome by shared genes and environment.
Standard paraffin sections were prepared and stained with hematoxylin and eosin and Alcian blue and examined by an independent pathologist.
Standard photographs and skin biopsy specimens were obtained at baseline , and at @number@ and @number@ months after the start of treatment.
Standard pre- and postinjection photographs were taken and compared to analyze the success of the procedure.
Standard psychometric measures were not related to RSN composite scores.
Standard questionnaires assessing anxiety , depression , cognition , smell , nonmotor symptoms , and rapid eye movement ( REM ) sleep behavior were administered.
Standard regimen of testosterone esters ( @number@ mg / 3 weeks ) was given to @number@ patients.
Standards in ROB evaluations in Cochrane and paper-based SRs were compared using the Fisher's exact test.
Standard subjective questionnaires might not reflect the sorts of concerns that bring individuals to clinical attention.
Standard times for pedestrian lights in Dublin pelican crossings are specified in the Traffic Management Guidelines ( TMG ) .
Standard treatment for acute poisoning involves administration of intravenous atropine , oxime 2-PAM to counter AChE inhibition and diazepam for CNS protection.
Standard treatment of organophosphorus ( OP ) poisoning includes administration of an antimuscarinic ( e.g. , atropine ) and of an oxime-based reactivator.
Standard weighting procedures were used to construct sample weights considering the multistage stratified cluster sampling survey scheme.
Standing balance is an important motor task.
Standing on a moving surface induced larger target-gaze errors.
Standing sequences A and B are defined as supine-to-standing and , respectively.
Standing , walking , and running are sensorimotor tasks that develop during childhood.
Staphylococcus aureus ( SA ) constitutes a significant problem.
Staphylococcus aureus ( S. aureus ) is a prominent human and livestock pathogen investigated widely using omic technologies.
Staphylococcus aureus was isolated from @number@ joint aspirations and Pseudomonas Aeruginosa from one patient.
Staphylococcus epidermidis is the major bacterial strain.
StAR activity facilitates the supply of cholesterol substrate into the inner mitochondrial membranes where conversion of the sterol to a steroid is catalyzed.
Start date @date@ , end date @date@ .
Starting at low doses and proceeding in a gradual manner , these agents have proven efficacy in decreasing the risk of stroke and cardiovascular events.
Starting at @number@ perceived control declines an average of a quarter of a SD per @number@ years.
Starting from mortality and survival data , incidence and prevalence were derived using a statistical back-calculation approach.
Starting from @number@ phenylketonuria is part of the newborn screening program in Hungary.
Startle reaction was also remarkable in all patients , although myoclonus was generally mild.
Start-up time was determined from video recordings and walking speed measured using timing gates.
Stasis of blood flow and prothrombotic environment in the stented region can lead to the formation of very late stent thrombosis.
STAT3 phosphorylation is dose dependently activated by IL-21 and inhibited by rhIL-21R-Fc in vitro using T cells.
State and national patterns of female pelvic surgeon density were mapped graphically using ArcGIS software and @number@ US Census demographic data.
State and trait anxiety , depression , general memory , specific memories , life satisfaction and subjective happiness were measured.
Statement of contribution What is already known on this subject ?
STATEMENT OF CONTRIBUTION : What is already known on this subject ?
STATEMENT OF PROBLEM : Advanced high-strength dental ceramics based on zirconium oxide are widely used for dental restorations.
STATEMENT OF PROBLEM : A key factor of an implant-retained facial prosthesis is the success of the bonding between the substructure and the silicone elastomer.
STATEMENT OF PROBLEM : Because of the high mechanical strength of zirconium dioxide , the metal in fixed partial prostheses can now be replaced.
STATEMENT OF PROBLEM : Information about the influence of zirconia crown surface treatment and cement type on the retention of zirconia crowns is limited.
STATEMENT OF PROBLEM : The lack of long-term bond stability between resin cements and dentin may compromise the success of indirect restorations.
STATEMENT OF PROBLEM : Yttria-stabilized zirconia used for the fabrication of crowns and fixed prostheses may require intraoral adjustments after placement and cementation.
STATEMENT OF RELEVANCE : The effect of occupational activity on cognitive functioning is under-researched.
STATEMENT OF SIGNIFICANCE : Current mesenchymal stem cell ( MSC ) culture methods result in premature cellular senescence or loss of differentiation potential.
STATEMENT OF SIGNIFICANCE : Obtaining robust , mature elastic fibers is a key obstacle in tissue-engineered blood vessels.
STATEMENT OF THE PROBLEM : The color stability of resin cements plays a major role in the esthetic performance of porcelain laminate veneers.
Statements were then sent to the experts for validation.
State @number@ respiration was also measured.
State-of-the-art appearance-based age estimation methods from the literature are implemented as baseline.
States are shifting Medicaid spending on long-term services and supports from institutional to home and community-based services , a process known as rebalancing.
States should examine opportunities to assist young adults with serious mental health problems who are aging out of Medicaid enrollment categories for children.
States ' socioeconomic and policy contexts appear particularly important for older adults.
States with larger increases in the quality of diagnostic procedures , drugs , and physicians did not have larger increases in per capita medical expenditure.
States with LGBT CMPs reported the highest levels of racial / ethnic / cultural diversity initiatives and high levels of statewide LGBT protective policies.
Stathmin and fut8 were identified as downstream targets regulated by loss of PAX2 and mutation of p53 in MOE cells.
Static and absolute accuracy was assessed by comparing the AHRS orientation measurement to those obtained using an optical gold standard.
Static and dynamic balance was measured on a force platform.
Static balance was evaluated using the blind monopodal stance static balance test.
Static FC was calculated as Fisher's z-transformed correlation coefficient.
Static mechanical compression tests were performed on the materials , as well as fatigue tests to assess their static and dynamic mechanical behaviors , respectively.
Static postural control was measured during bipedal stance , and dynamic postural control was obtained while walking on an instrumented walkway.
Static pressure at @number@ % of FVC [ Pst ( L ) 50 % ] was estimated based on age.
Static stabilometry and the Montreal Cognitive Assessment ( MoCA ) test were performed.
Statin exposure was ascertained based on prescriptions dispensed between @date@ and @date@ .
Statin , renin-angiotensin inhibitors and anti-osteoporosis drug are well studied in recent years.
Statins and antiplatelet drugs have proven beneficial in both primary and , especially , secondary prevention of coronary events in older adults.
Statins are the most widely used cholesterol-lowering drugs in clinical practice.
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation.
Statins improve the removal from plasma of chylomicrons in a dose dependent manner.
Statins inhibit the activity of enzyme 3-hydroxy-3-methyl-acetyl coenzyme A reductase and further inhibit cholesterol synthesis.
Statins may promote EPC / CEC mobilization in the peripheral blood.
Statin treatment also introduced increased mRNA levels of MMP-1 , MMP-3 , MMP-13 , TIMP-1 and decreased levels of collagen type @number@ and @number@
Statin use appears to regulate cVMR and the cVMR training response.
Statistical analyses comprised of Cox proportional hazard regression models.
Statistical analyses comprised Pearson's c2 test , Wilcoxon test , linear regression model for statistical analysis and different multivariate linear regression analyses.
Statistical analyses include individual study results as well as a meta-analysis on the combined results of the three studies.
STATISTICAL ANALYSES PERFORMED : Descriptive statistics and multiple linear regression were applied.
STATISTICAL ANALYSES PERFORMED : Multivariate logistic regression models were stratified by gender to estimate the association between food insecurity and higher weight status.
STATISTICAL ANALYSES PERFORMED : Normalized 36-Item Short-Form Survey component scores were used in analysis of covariance to calculate multivariable adjusted mean scores.
Statistical analyses show substantial sex differences , age variations , and sex by age interaction effects for all variables examined.
Statistical analyses used linear mixed models adjusted for randomization levels.
Statistical analyses were based on competing risk framework.
Statistical analyses were carried out in order to identify significant differences between the features computed from the distinct groups that could allow for their discrimination.
Statistical analyses were conducted using R. FINDINGS : Attitudes vastly differed between healthy participants , physicians and melanoma patients.
Statistical analyses were conducted using SPSS software.
Statistical analyses were conducted using Statistica , version @number@
Statistical analyses were conducted with and without participants who developed dementia within @number@ years after the MRI scan session.
Statistical analyses were corrected for age , sex , joint , and technical covariates.
Statistical analyses were made retrospectively on a prospective database.
Statistical analyses were performed both with inclusion and exclusion of visibly incorrect segmentations.
Statistical analyses were performed on the interrelationships among the study variables.
Statistical analyses were performed to assess the associations between age-related hearing loss and 12S rRNA gene variants.
Statistical analyses were performed to determine the influence of age on complication rate.
Statistical analyses were performed using Cox regression.
Statistical analyses were performed using linear regression analysis , analysis of variance , and multiple comparison analysis.
Statistical analyses were performed using Pearson's correlation coefficients.
Statistical analyses within and between all age groups were performed using analysis of variance tests.
Statistical analyses with percentage estimates and @percent@ confidence intervals ( CIs ) were performed.
Statistical analyses with two-way ANOVA were conducted ; the level of significance was set at p < @number@
Statistical analysis ( ANCOVA ) showed a significant difference in DHEA-S levels between the groups ( p = @number@ ) .
Statistical analysis and association between biostrumental and biochemical data were investigated.
STATISTICAL ANALYSIS : Descriptive statistics ( mean ± standard deviation ) were used to characterize the population demographics , anemia rates , and diet.
Statistical analysis did not identify significant differences in genotype or allele frequencies between healthy controls and patients with ET ( p > @number@ ) .
Statistical analysis included multivariate stepwise backward linear regression and multivariate logistic regression.
Statistical analysis included Paired Samples t-tests and Repeated Measures Analysis of Variance.
Statistical analysis included univariable followed by multivariable Poisson regression and step-wise reduction to refine the multivariable model.
Statistical analysis includes descriptive statistics , Hi-square test , Spearman's correlation coefficient , and Mann-Whitney U test.
Statistical analysis of previously published cases suggested there is a trend toward increasing disease severity and disease penetrance with increasing duplication size.
Statistical analysis of seizure occurrence in time bins was carried out using binomial calculations. p-Values < 0.05 were taken as significant.
Statistical analysis of the percentage of the area occupied by elastin showed a statistically significant difference in favor of the controls.
Statistical analysis of the results was performed using the Student's t-test.
Statistical analysis revealed a significant impact of composition on tanδ ( P < @number@ ) .
Statistical analysis revealed that all the aforementioned factors are statistically significantly associated with sRAGE levels.
Statistical analysis showed a significant increase in dermal thickness ( mean variation @percent@ , ( @percent@ confidence interval = @date@ @number@ ) .
Statistical analysis showed differences in both overall MNA scores and MNA assessment scores.
Statistical analysis showed higher C. trachomatis prevalence in the younger age groups , and this peaked at younger age in women than in men.
STATISTICAL ANALYSIS : Simple comparisons and mixed models of multiple ordinal regression.
STATISTICAL ANALYSIS USED : Statistical Package for Social Sciences ( SPSS Inc.
Statistical analysis was carried out using general linear mixed models , taking into account variances associated with time of assessments and with patients.
Statistical analysis was carried out using Review Manager @number@
Statistical analysis was carried out with SPSS @number@
Statistical analysis was done by means of descriptive statistics and logistic regression analysis.
Statistical analysis was done using a generalized linear model.
Statistical analysis was done with two-way analysis of variance with Holm-Sidak's correction for multiple comparisons.
Statistical analysis was performed at a significance level of @percent@.
Statistical analysis was performed by One-Way ANOVA and a Newman-Keuls or Student's post-hoc test.
Statistical analysis was performed by the Wilcoxon's method.
Statistical analysis was performed comparing data between treated and untreated eyes.
Statistical analysis was performed on gray matter qT1 and qT2 values.
Statistical analysis was performed to assess factors related to trauma characteristics.
Statistical analysis was performed to compare clinical and operative parameters between these two groups.
Statistical analysis was performed using 1-way ANOVA and the Tukey post hoc test to perform multiple comparison tests ( α = .05 ) .
Statistical analysis was performed using a mixed linear effects model using the R-statistical package.
Statistical analysis was performed using analysis of variance ( ANOVA ) , followed by post-hoc by Duncan's.
Statistical analysis was performed using discrete time proportional odds ( logistic regression ) duration models for each birthday.
Statistical analysis was performed using log-transformed normalized CT values using SAS @number@
Statistical analysis was performed using multiple regression , principal component ( PCA ) and discriminant analysis.
Statistical analysis was performed using Pearson's correlation coefficient at the @percent@ level of significance.
Statistical analysis was performed using percentages and chi-square test.
Statistical analysis was performed using the SPSS software package ; significance was assumed for p < @number@
Statistical analysis was performed using the Student t , chi-square and Fisher tests , considering p < 0.05 as significant.
Statistical analysis was performed using three-way ANOVA and Tukey's post-hoc tests.
Statistical analysis was performed with 1-way and 2-way ANOVA.
Statistical analysis was performed with nonparametric test methods ( p < @number@ ) .
Statistical analysis was performed with repeated-measures two way ANOVA and Tukey's test ( p < 0.05 ) .
Statistical analysis was performed with STATA version @number@
Statistical analysis was undertaken using ANOVA ( p < 0.05 ) .
Statistical analysis was used to assess differences in VSQ scores.
Statistical analysis with generalized estimating equations and repeated measures ANOVA tests was used.
Statistical assessment was performed by use of non-parametric tests.
Statistical assessment was performed by use of SPSS @number@
Statistical association with CTS was determined for five sociodemographic and nine medical factors.
Statistical calculations were performed using a permutation ANOVA with bootstrap confidence intervals.
Statistical comparisons accounting for multiple comparisons were made between groups with and without cerebrovascular risk factors.
Statistical comparisons are made for fertility , mortality , ageing , migration and population density.
Statistical comparisons between groups were performed using appropriate tests with the aid of software.
Statistical correlations between the echocardiographic parameters and age , body weight , sex , and heart rate were investigated.
Statistical correlation was performed between estradiol , FSH blood levels and relative variation in moles dimensions.
Statistical database models are used as an alternative to randomised controlled trials ( RCTs ) to assess influenza vaccine effectiveness.
Statistical data processing included calculation of arithmetic-mean values , their errors , confidential intervals ( excel ) .
Statistical differences in diabetes care management emerged relating to gender , age , diagnostic latency period , comorbidity and citizenship.
Statistical efficiency is affected by ascertainment bias , and careful adjustment can lead to substantial improvements in statistical power.
Statistical evaluation correlating age with central and nasal fat pad change was performed.
Statistical evaluation of the data included percentage , median and Kruskal Wallis Test and Mann-Whitney U-test.
Statistical evaluations evidenced reduction of pain , improvements of nerve function and trophism.
Statistical evaluation was performed with age , gender , and ethnicity as covariates.
Statistical fine-mapping at this locus pointed to RBPMS at this locus and excluded nearby GTF2E2.
Statistical interaction between protein intake % and Ca ( total , dietary , supplemental ) intake was examined.
Statistical linear regression was used to explore relationships between nerve excitability and the independent variables.
Statistically correcting for sympathetic nerve activity abolished the age-related difference in arterial compliance ( P = 0.35 ) .
Statistically significant associations with AMD included increasing age and family history of the condition.
Statistically significant changes occurred both for self-assessment of a range of practice aspects and for diabetes care measures.
Statistically significant change was identified pre-post training on all outcome measures.
Statistically significant correlation between BNP concentration and a functional class of heart insufficiency is revealed.
Statistically significant correlations between the improvements in neurological function and both injury size and level were found.
Statistically significant correlations were intra-nurse coordinator relational coordination indices and two patient perception of care factors ( information and education and patient's preferences ) .
Statistically significant declines in the RMBPC and PW-BCIP were observed over the study period.
Statistically significant decrease on pain intensity and disability were also found in both groups.
Statistically significant differences between groups attending to the therapeutical adherence to clinical guidelines ( p < @number@ ) were observed.
Statistically significant differences in Cho / NAA were also found among the @number@ age groups.
Statistically significant differences in GIP memory scores between patients with dementia and non-demented patients were found ( p < @number@ ) .
Statistically significant differences in kurtosis values were not found in the lateral white-matter bundles of the spinal cord.
Statistically significant differences in life span cholesterol trajectories according to gender and use of cholesterol-lowering medications were also detected.
Statistically significant differences in mtDNACD4977 expression were identified among all of the groups ( P < 0.001 ) .
Statistically significant differences of the CIP speed were found in all age groups of the investigated persons with different levels of FNMP.
Statistically significant differences on NCF and QOL were observed between CRT and RT arms at @number@ months.
Statistically significant differences were recorded regarding dyslipidemia ( @percent@ vs @percent@ , P < 0.001 ) .
Statistically significant group differences were also present on Trails-B and WAIS-R Digit Symbol performance ( p < @number@ ) .
Statistically significant improvements were seen for skin texture , skin laxity , wrinkles , enlarged pores , and acne scars.
Statistically significant interrelations between the studied parameters and age of the examined persons were determined in the blood plasma.
Statistically significant superiority of EGb @number@ over placebo was confirmed by responder analyses as well as for patients suffering from dementia with neuropsychiatric symptoms.
Statistically significant trend was observed in @percent@ CpG loci before adjustment for cell-type composition and in @percent@ loci after adjustment.
Statistically within the normal ageing and cataract populations , visual acuity and straylight vary quite independently from each other.
Statistical mediation analysis was used to study intermediate mechanisms of the telomere-mitochondrial axis of ageing.
Statistical methods include proportional Cox hazard modeling and Relative Excess Risk due to Interaction ( RERI ) to assess interactions.
STATISTICAL METHODS : We used random effect models in each of the meta-analyses calculating with the DerSimonian and Laird weighting methods.
STATISTICAL METHODS : We used random effect models in each of the meta-analyses calculating with the DerSimonian and Laird weighting methods.
Statistical modeling provides an avenue for forensic anthropologists and bioarchaeologists to increase the accuracy of traditional aging methods.
Statistical modeling was by general estimating equations and Cox model regression.
Statistical models indicated that a variety of covariates and their interaction influenced SERT availability measured by distribution volume ratios ( DVR ) .
Statistical package SPSS version @number@ and Amos @number@ were used for the analysis.
Statistical parameters were mapped on the anatomic images to facilitate visual inspection.
Statistical parametric mapping and multiple regression models were used to examine clinical , CMRglc and COX data across groups.
Statistical parametric mapping and voxel based morphometry were used to assess the associations of the identified NPs with AD biomarkers.
Statistical significance reached at P value < 0.05.
Statistical significance was considered at p ≤ @number@ significance level.
Statistical significance was considered to exist when P≤ @number@
Statistical significance was defined with an α set at P≤.05.
Statistical significance was estimated with permutation test.
Statistical tests for interactions assessed whether associations differed among age groups.
Statistical tests for stability of diurnal type were based on transition matrices and p values obtained using likelihood ratios.
STATISTICA software was adopted to perform an unpaired t test.
STATISTICS : analysis of variance ; Bonferroni's post hoc analysis , Kaplan-Meier-Log Rank test ( α = @number@ ) .
Statistics-Cox models adjusted for demographics , comorbidity , and substance use.
Statistics included univariate and multivariate regression analysis.
Statistics in Medicine Published by JohnWiley & Sons Ltd.
Statistics on depression in later life are presented with a discussion of physical health comorbidities.
Statistics show that children are at an increased risk.
Statistics used for data analysis included frequency distributions , Spearman's rho correlation coefficient and the Mann-Whitney test.
Statistics were done using ANOVA and t-tests.
Stature is also a marker for levels of insulin-like growth factor ( IGF ) -I in childhood.
Status cribrosum was found in @percent@ of participants. dVRS were also highly prevalent within the hippocampus ( @percent@ ) and hypothalamus ( @percent@ ) .
Staying active and in good health were not just talked about as ways to achieve personal well-being.
STC should be used to improve EB in primiparous women.
Steadiness decreased ( force fluctuations increased ) more during high CD than control.
Steadiness decreased in both sexes when high CD was imposed.
Steady-state pupil constriction was greater under blue than green light exposure in both age groups and increased with increasing irradiance.
Steady state walking speed was assessed under single- and dual-task conditions at preferred and fast walking speed.
Steaks aged @number@ d had the lowest LL and GM WBSF and steaks aged 2d had the highest LL , GM , and ST WBSF.
Steaks from steers castrated at @number@ mo had lower GM WBSF than those from bulls.
Steaks from steers had lower ( more tender ) LL Warner-Bratzler shear force ( WBSF ) values than those from bulls.
Steeper decline in processing speed correlated with a steeper increase in somatic symptoms of depression over time.
Steeper decrease of BMI and low late-life BMI are associated with higher risk of dementia and AD.
Stem and progenitor cells are characterized by their abilities to self-renew and produce differentiated progeny.
Stem cell activity is tightly regulated during development and in adult tissues through the combined action of local and systemic effectors.
Stem cell-based disease modeling is an emerging technology for the mechanistic study and therapeutic screening of complex ocular pathologies.
Stem cell biology provides a natural framework and experimental methods for understanding the mechanistic basis of life-history evolution.
Stem cell frequencies were determined with multiparameter flow cytometry and using an internal control to determine the intrinsic variance of the assays.
Stem cell function is essential for organismal homeostasis , providing a renewable source of cells to repair damaged tissues.
Stem cell renewal and proliferation is strongly regulated during aging of the organism.
Stem cell research holds a promise to treat and prevent age-related degenerative changes in humans.
Stem cells appear to be progressively lost with aging and only the highest quality stem cells survive.
Stem cells are able to generate both cells that differentiate and cells that remain undifferentiated but potentially have the same developmental program.
Stem cells are defined by their ability to self-renew and their multi-potent differentiation capacity.
Stem cells are essential for normal organ development , maintenance , and repair.
Stem cells are regulated by a combination of shared and tissue-specific mechanisms and are distinguished from restricted progenitors by differences in transcriptional and epigenetic regulation.
Stem cells are undifferentiated cells and have multi-lineage differentiation potential.
Stem cells are undifferentiated cells , which have the important properties of self-renewal and differentiation.
Stem cells are uniquely able to self-renew , to undergo multilineage differentiation , and to persist throughout life in a number of tissues.
Stem cells are unspecialized cells , which have the capacity to self-renew and generate differentiated cell types.
Stem cells , ciliary neurotrophic factor , rheopheresis , ozonated autohemotherapy and prostaglandins show promise in stabilizing or improving visual acuity.
Stem cells have been found in most tissues / organs.
Stem cells have recently been shown to play important roles in wound healing.
Stem Cells @number@ ; 35 : 1141-1153.
Stem Cells @number@ ; 35 : 1246-1258.
Stem Cells @number@ ; 35 : 1392-1401.
Stem Cells @number@ ; 35 : 1443-1445.
Stem Cells @number@ ; 35 : 597-610.
Stem cells persist in specialized niches in the adult mammalian brain.
Stem cell therapy for stroke has advanced from the laboratory to the clinic , but remains as an experimental treatment.
Stem cell tourists may not be aware of the information they should seek when consulting these clinics , or of the potential risks involved.
Stem cell transplantation is a potentially important means of treatment for a number of disorders.
Stem cell transplantation is a potential therapy for regenerative medicine , which aims to restore tissues damaged by trauma , aging , and diseases.
Stem cell transplantations are therefore expected to be of considerable significance in the future treatment of ocular diseases.
Stenosis of the internal carotid is the most common cause of central retinal artery occlusion ( CRAO ) .
Stent degradation was rare and consisted of corrosion and rupture.
Stent graft localization / deployment was more precise in the RACP group ( 2±1 versus 5±2 mm , P < 0.001 ) .
Stenting should be avoided in older patients , but may be as safe as endarterectomy in younger patients.
Stents were previously positioned for both urolithiasis and during the management of other urologic diseases and / or procedures.
Stent type may influence the benefit of prolonged DAPT. © @number@ Wiley Periodicals , Inc.
Step and stance time improved after CPAP.
Step initiation , preparatory and swing phases , and foot-contact time were extracted from data on center of pressure and ground reaction force.
Step length considerably decreased with WT.
Step length was the only individual WWT parameter that predicted falls [ hazard ratio ( HR ) @number@ p = @number@ ] .
Step @number@ ( for those failing Step @number@ ) was a 10-item version of the Unified Parkinson Disease Rating Scale and the Mini-Mental State Examination.
Step @number@ was to move beyond diagnostics and mechanistical risk assessment , towards providing a foundation for personalized therapeutics.
Steps , distances , and speeds ( on foot and in vehicle ) were determined.
Steps must be taken immediately to resolve these issues in an effort to keep an adequate supply of nurses at the bedside.
Steps per day declined from baseline to the 12-week follow-up ; there was also a trend for declines in moderate-vigorous PA.
Step training in both forward and lateral directions appears to induce no negative transfer effects in diagonal stepping.
Step width ( SW ) did not change as a function of age , but SW variability was higher for the two older groups.
Stepwise analysis identified distensibility and moisture content of the lower labial mucosa as predictive factors of age.
Stepwise discriminant modeling showed correct classification of @percent@ of patients with AD , @percent@ of patients with DM2 , and @percent@ of patients with FTD.
Stepwise models identified combinations of metabolites to explain approximately @percent@ of the variability inherent in muscle CSA or the FFMI.
Stepwise multiple linear regression analysis revealed that VFA was the strongest predictor of plasma LECT2 levels.
Stepwise multiple regression models were used to determine the proportion of variance in burst characteristics explained by clinical measures of physical function in PD.
Stepwise regression analyses revealed that ankle mean arterial pressure was the strongest independent predictor of carotid augmentation index.
Stepwise regression analysis indicated that facial pigmentation was associated with carotid IMT via visceral fat area.
Stepwise regression analysis was used to examine the relationships between BMD and strength measures , controlling for subject age and years since menopause.
Stepwise regression kept b-age , basal NIH Stroke Scale , sex , p-mRS , and recanalization treatment as better explanatory variables , instead of c-age.
Stepwise regression yielded a predictive nonunion model with @number@ significant explanatory variables ( all , p≤0.003 ) .
Stepwise removal of up to three items reduced SN slightly.
Stereological counting of NM content , α-synuclein content , and TH immunoreactivity revealed significant accumulation of NM and α-synuclein in neurons during the aging process.
Stereopsis is the primary cue underlying our ability to make fine depth judgments.
Stereoscopic depth perception utilizes the disparity cues between the images that fall on the retinae of the two eyes.
Stereothresholds were measured using the Frisby Stereo Test , which utilizes a four-alternative forced-choice staircase procedure.
\ "Stereotype threat \ " is often thought of as a singular construct , with moderators and mechanisms that are stable across groups and domains.
Stereotype threat often incurs the cost of reducing the amount of information that older adults accurately recall.
Stereotype threat should be associated with poor performance when the assessment emphasizes gaining correct answers , but not when it emphasizes avoiding mistakes.
Stereotypical behaviors in FTD are often considered in contrast to obsessive-compulsive disease ( OCD ) .
Sterile-inflammation is a form of pathogen-free inflammation caused by mechanical trauma , ischemia , stress or environmental conditions such as ultra-violet radiation.
Steroidogenic acute regulatory protein ( StAR ) is essential for steroid hormone synthesis in the adrenal cortex and the gonads.
Steroidogenic enzymes and receptors are expressed in glutamatergic neurons.
Steroid pulse therapy was partially effective , although he continued to have dementia with myoclonus and psychiatric symptoms , despite resolution of the consciousness disturbance.
Steroids stimulated fibroblast contraction but not α-SMA expression.
Steroids were quantified by liquid chromatography-tandem mass spectrometry.
Sterol metabolites are critical signaling molecules that regulate metabolism , development , and homeostasis.
Stiffening of the proximal aorta is strongly associated with age and hypertension.
Stiffness and feeling tired were the most common symptoms.
Stiffness for the annulus region was significantly higher compared to the cusp region at all stages.
Stiffness of EC was measured by atomic force microscopy indentation while Rho GTPase activity was quantified by Rho G-LISA assay.
Stigma is recognized as a barrier to the prevention , care , and treatment of HIV , including engagement in the HIV care continuum.
Stigma is then placed in a historical context of HIV and AIDS , and events exacerbating HIV stigma are discussed.
Stigma management strategies are outlined and finally , implications of working with older adults related to HIV stigma are provided.
Stigmatization throughout the lifespan may have a causal influence on barriers to care , social isolation , and concomitant health disparities.
Stilbenoid compounds consist of a family of resveratrol derivatives.
Stillbirth-associated placentas showed similar changes in oxidation of DNA / RNA and lipid , lysosomal location , and autophagosome size to placentas from late-term.
Still , body composition is rarely factored in routine HF care.
Still , HIV alone also conferred increased risk ( HR @number@ @number@ % CI @number@ @number@ ) .
Still , how exercised muscle signals to induce system-wide health improvement remains poorly understood.
Still lacking , however , is a clear understanding of how sustained visual attention varies across the broad sweep of the human life span.
Still , laser resurfacing has a place in the ( field ) treatment of widespread AKs and extensive photodamage.
Still @number@ patients did not remain seizure-free after addition of another antiepileptic drug.
Still , old MZ pairs with strikingly similar DNA methylation were also observed at these loci.
Still , reinvestigation in a larger cohort similar to this , as well as a meta-analysis , is important to confirm these results.
Still , the determinants of grandparents ' involvement in childcare ( e.g. , age , geographic proximity ) are fairly similar in both countries.
Still , the dissection of causal relationships has turned out to be remarkably difficult.
Still , the interplay between structural and functional neuroplasticity is poorly understood , and studies of treatment-induced long-term neuroplasticity are rare.
Still , the majority of people do not comply with current recommendations for physical activity.
Still , these findings indicate that , of the entire pathway , variation in BER might influence longevity the most.
Still , they fail to anticipate self-propelled ( SP ) spoons that move toward the mouth and manual combing actions directed toward the head.
Still , they felt limited and demotivated due to the poor working conditions , outsourcing of the division , and the prevailing workload organization.
Still , they show a considerable life expectancy after ICU admission even though they get less invasive care than younger patients.
Still unresolved are the mechanisms and factors that govern Nrf2 distribution between its subcellular locales.
ST improves or reverses some of the adverse effects of fibromyalgia and rheumatoid arthritis , particularly pain , inflammation , muscle weakness and fatigue.
ST improves performance in functional tasks important for ADLs.
Stimulated whole saliva was collected.
Stimulating beverages were main related factor for yin deficiency syndrome ( P < 0.05 ) .
Stimulating microglia to an M2 phenotype may thus slow down the progression of AD and could be a target for future therapies.
Stimulation of autophagy using rapamycin may represent a novel strategy to prolong lifespan and combat aging-associated diseases.
Stimulation of old bone marrow cells by NPY treatment rejuvenated the growth characteristics of aging bone marrow cells as a result of Y5R overexpression.
Stimulation with the cytokine TGF-β1 had distinct effects on some tendon-related genes in both tensioned and de-tensioned tissue.
Stimuli comprised three concentric rings containing five or @number@ equally spaced dots.
Stimuli that are proximal in time and space are likely to be bound together by the brain and ascribed to a common external event.
Stimuli varied on valence ( pleasant , neutral , and unpleasant ) and arousal ( high and low ) dimensions.
Stimuli were dots presented at three different eccentricities along the horizontal , oblique , and vertical diameters and three interstimulus intervals.
Stimuli were embedded in stationary noise alternating with modulated noise.
Stimuli were @number@ ms trains , consisting of @number@ identical clicks ( @number@ ms burst of white noise ) delivered binaurally.
Stimulus and electrode differences plus smoking and aging effects can guide neurodiagnostic AMLR protocols , especially in young adult smokers.
Stimulus bandwidth did not affect performance.
Stimulus conditions were blocked according to these conditions with baseline ( unisensory ) performance assessed during the multisensory block.
Stimulus duration was 500ms.
Stimulus type was the within-subject independent variable , and age group was the between-subject independent variable.
STM glucose and insulin responses were normalized by @number@ and @number@ months.
Stoke remains a leading cause of death and disability with limited treatment options.
Stool specimens were collected and tested for @number@ enteric viruses and bacteria.
Stopping a benzodiazepine was associated with a significantly reduced fall risk ( OR @number@ @percent@ CI @number@ @date@ ) .
Stopping antihypertensive medication during the study period predicted more severe worsening of YEM ( β = 360.2 mm Hg ; P = 0.008 ) .
Stopping RAGE-dependent signaling may hold the key to interrupting cycles of cellular perturbation and tissue damage in these disorders.
Stopping rules therefore were anytime six failures had occurred.
Storage conditions had little effect on NNR.
Storage in air or water for @number@ days did not seem to cause further effects.
Storage in ethanol for @number@ days caused a strong change of the sample morphology and the DMTA results were not reliable.
Storage in heptane for @number@ days may cause plasticization and probably some degradation of the filler-silane bond and polymer matrix.
Stories of going about daily occupations and particular moments in the day were elicited during conversational-style interviews.
Stories passed down from generation to generation sometimes teach , record history , provide examples , or inform.
Stories were repeated across practice blocks , and then the noun phrases were presented in novel sentence frames in a transfer task.
Storing silicone elastomer in simulated sebum under light aging induced the greatest color changes.
ST + placebo did not change bioavailable testosterone and lean body mass.
Strain-encoded ( SENC ) imaging was additionally performed to investigate possible effects of myocardial strain on global or segmental T2 values.
Strain rates along and in the cross-section of the fiber were calculated from the SR tensor and used to derive the out-plane SR.
Strains of Achilles tendons ' proximal , middle and distal parts were assessed semi-quantitatively with comparing a reference tissue.
Strains resistant to tetracycline ( @percent@ ) were also resistant to erythromycin.
Strains were identified by Phoenix100 system , 16S rRNA sequencing , and two MALDI-TOF MS platforms ( Bruker Biotyper , Vitek MS ) .
Strategic FA assessments provided the most robust discriminative power to differentiate SIVD from AD , and FAB may serve as an additional cognitive marker.
Strategies aimed at reducing these disparities may favorably affect the incidence of dementia.
Strategies are needed for determining what types and levels of reduced function provide a threshold for disqualification in drivers with medical disorders.
Strategies are needed for the early identification of risk factors to prevent nutrition problems.
Strategies are presented to manage common complications.
Strategies critical for success were an interdisciplinary team , collaboration with community organizations , and alternatives to aggressive end-of-life care.
Strategies for approaching generational issues that affect teaching and learning , mentoring , and technology in emergency medicine ( EM ) have been reported.
Strategies for early detection of CKD are needed because , in many cases , CKD remains asymptomatic until late stages.
Strategies for therapy and intervention for ED should acknowledge this basic evolution with time.
Strategies how to manage senescent phenotypic change in VSMC may provide novel therapeutic opportunities for the prevention of vascular calcification.
Strategies include such actions as timing events , regulating one's presence , and composing social groups.
Strategies such as educating / coaching and evaluating and feedback were key to sustaining the change.
Strategies ( such as guided tissue regeneration ) have been developed to guide and control regeneration using bioresorbable membranes and bone grafts.
Strategies that reduce literacy disparities should be designed and evaluated.
Strategies to address these increasing demands on the health system must include expanded physician training.
Strategies to ameliorate or to obviate these precipitating factors are most effective in preventing DHF and its exacerbations.
Strategies to elaborate such approaches require knowledge of specific immune system involvement in disease pathogenesis.
Strategies to enhance top-down attentional control may be particularly relevant in late-life GAD treatment.
Strategies to enhance weight loss with a high fat-to-lean ratio in overweight / obese older adults are important since lean loss could exacerbate sarcopenia.
Strategies to expand functional cells have focused on discovering and controlling mechanisms that limit the proliferation of human β cells.
Strategies to help generate a feeling of home in long-term care settings are shared.
Strategies to improve public transport and minimize age-related barriers may translate from urban to rural contexts.
Strategies to mitigate age-dependent dysregulation in glycemia should therefore target systemic and / or local inflammation and fibrosis of the aged islet vasculature.
Strategies to overcome silence and invisibility on the part of service providers in the health and social services system are considered.
Strategies to reduce immune activation or augment pTfh function may enhance antibody responses in the aging HIV-infected population.
Strategies to reduce PIM use are thus urgently needed.
Strategies to regulate aging-associated signaling pathways are expected to be effective in the delay and prevention of age-related disorders.
Strategies to slow the growth of NAFLD cases and therapeutic options are necessary to mitigate disease burden.
Strategies to suppress age-associated vascular changes could ameliorate vascular damage associated with hypertension.
Strategies which encourage older people to eat meals and be physically active with others may assist to improve their health.
Strategy becomes monotonically more conservative with age , whereas ability peaks in the early 40s and is followed by a gradual decline in older adults.
Strategy changes were also observed to compensate for impaired pursuit during whole body rotation while the target moved with the head.
Strategy scores differed between both age groups , whereas vibration only affected the older group ( p = @number@ ) .
Stratification analyses were run to determine whether BMI changes depended on baseline BMI status.
Stratification by known cancer risk factors , history of cancer , other randomized treatment , and follow-up time showed no significant interactions.
Stratification by measurement technique , study design , study size , and ethnicity explained heterogeneity in certain cardiometabolic outcomes.
Stratification demonstrated an increased effect size depending on various study characteristics.
Stratification into a high-risk versus low-risk patient population is recommended.
Stratification into CF children ( n = @number@ ) and adults showed comparable values for protein digestibility and similar kinetic responses to pancreatic enzyme intake.
Stratification of patients according to survival status revealed age-related tumor expression patterns of both H3K9Ac and H3K27me3.
Stratified analyses by chronic disease status were also performed.
Stratified by age , the HR for stroke events was @number@ ( @percent@ CI , @number@ @date@ ) for individuals aged 18-49 years.
Stratified by time to infection , larger proportions of knee SSIs occurred after @number@ days versus hip SSI.
Stratified estimates of effects were obtained using subject status ( e.g. , age≥75 years , diabetes , CVD ) at each visit.
Stratified multiple linear regressions were undertaken to assess disability differences by sex and residence , controlling for other biological and socioeconomic determinants of disability.
Stratified multivariate analyses were used to further examine the effect of race / ethnicity on LTCI ownership.
Stratified random sampling procedures were used to select provider types across five geographic regions in Ohio.
Stratified results showed a significant relationship in black ( P = @number@ ) but not white ( P = @number@ ) participants.
Stratifying risk factors to identify patients at risk for community-acquired multidrug-resistant pathogens should be considered when selecting therapy.
Stratifying sensor data by gender yielded significantly ( p < 0.05 ) increased accuracy in classifying frailty when compared with equivalent manual TUG time-based models.
Stratifying subjects according to APOE ε4 status , their genetic effects continued to be significant in the APOE ε4-negative subgroup.
Straylight defines disability glare , and causes symptoms of glare , haloes , hazy vision etc.
Straylight improvement after lens replacement was assessed by evaluation of preoperative and postoperative values.
Street signs and landmarks were overwhelming favorites as helpful wayfinding features.
Strength and strength / height tended to increase between @number@ and @number@ while the opposite occurred for strength / weight.
Strengthening of the health workforce has been adopted as one of the five priorities of the National Health Sector Strategy ( 2013-2025 ) .
Strength gained during phase @number@ was largely retained throughout detraining with only a slight reduction at the final time point.
Strength gains , but not aerobic capacity changes , mediate the cognitive benefits of PRT.
Strength / mass declines linearly with age and rates do not differ between young and older adults of both sexes.
Strength / mass is greater in @number@ than @number@ but differences are not significant in most age groups.
Strength measures were obtained using the Iowa Oral Performance Instrument ( IOPI ) .
Strength of association between cognitive and neuroanatomical indices depended on the executive task used in the study.
Strength of this model was assessed using an area under the curve ( AUC ) calculation , and out-of-sample AUC = 0.710.
Strength results in CR were similar , with decreases in absolute flexor and extensor strength , but increases when expressed relative to body mass.
STRENGTHS AND LIMITATIONS : Careful consideration was given to the selection of the final HIS-Q-SF items based on quantitative data and clinical expert feedback.
Strengths and limitations of the present study as well as suggestions for further studies were considered.
STRENGTHS AND LIMITATIONS : The main limitation of the present project was the short period of study and the animal model used.
STRENGTHS AND LIMITATIONS : The major strengths are the large , diverse patient population being treated in multidisciplinary clinical settings.
STRENGTHS AND LIMITATIONS : This large systematic analysis attempted to objectively assess the ejaculation latency in men with self-reported DE.
STRENGTHS AND LIMITATIONS : This study provides standardized data for the implantation of @number@ testosterone pellets.
STRENGTHS AND LIMITATIONS : Thus far , this is one of the largest samples of sexual behavior assessment in adults older than @number@ years.
Strengths and weaknesses of functional NIRS in the field of cognitive aging are presented and finally , novel perspectives of research are proposed.
Strengths include its ability to import clinical measures , interchangeable components , and its potential ability to identify latent risk factors.
Strength values increased with increasing core thickness for all IC , EM and K regardless of aging.
Strength was assessed using a handgrip dynamometer , and was normalized to body mass.
Strength was significantly related to small artery elasticity after adjusting for ethnic origin , leg lean tissue , age , and blood pressure.
Streptococcus gallolyticus subspecies gallolyticus ( SGG ) is potentially associated with colorectal cancer ( CRC ) and its precursors.
Stress affects people of all ages , but the lives of the elderly may particularly be affected.
Stress and ageing now consistently appear in the literature as factors that act upon the immune system in the way that is often damaging.
Stress and depression are associated with an acceleration of brain and bodily aging ; effects which have been attributed to chronic elevations of glucocorticoids.
Stress-and oncogene-induced accelerated senescence , replicative senescence in vitro and life-long cellular aging in vivo all can be described by 2-step model.
Stresses of these mucous membranes , seemingly minor , give rise to complaints of a perceived perineal discomfort , which is disproportionate to the causes.
Stress fractures mainly occur in the lower limb as a result of cyclic submaximal stresses.
Stressful events can have both short- and long-term effects on the brain.
Stressful premature senescent phenotypes induced by NaDC3 were markedly ameliorated via treatment with the antioxidants Tiron and Tempol.
Stress has been associated with negative changes observed during the aging process.
Stress has been identified as a main factor involved in the cognitive changes that occur during the aging process.
Stress imposed on frail older adults strengthens this negative feedback to activity , leading to disuse.
Stress induced by adversity is a probable cause of accelerated telomere shortening from an early age.
Stress-induced STAT3 activation is also unaffected in Tg-Ranbp2 ( R2944A-HA ) : : Ranbp2 ( - / - ) .
Stress is a major health burden in today's society.
Stressors not related to care recipients ' needs impact caregiver outcomes , yet are seldom reported.
Stressors related to physical health , however , do.
Stressors such as acute injury or chronic inflammation may induce SCS , which in turn exhausts organ regenerative potential.
Stress-related exhaustion has been linked to a pattern of selective cognitive impairments , mainly affecting executive functioning , attention and episodic memory.
Stress signals and physiological aging robustly increase autophagy with concomitant upregulation of Prom1 expression.
Stress temperature maintenance ( @number@ degrees C ) twice as decreased the longevity of all studied stocks however remaining interstock LS ranges.
Stretch also increased MMP-1 , MMP-2 , and MMP-3 activity , activin A secretion , and activity in ESC.
Stretch reflexes were measured from tibialis anterior and soleus during anterior and posterior perturbations , respectively.
Striae increased from @number@ to @percent@.
Striae of this bacterial strain with a MacFarland @number@ turbulence pattern were seeded from a spot of inoculated biomaterial using Müller-Hinton medium.
Striatal concentrations of METH and AMPH were also determined.
Striatal degeneration may contribute to cognitive impairment in older people.
Striatal dopamine ( DA ) functions , associated with cognitive performance , are linked to the TaqIA polymorphism of the DRD2 / ANKK1 gene.
Striated cells were significantly less present only in the lower thoracic part of the oesophagus.
Strict control was not consistently better than mild control in older adults.
Strict definition of phenotypes was planned : subjects were observed twice , and several hemodynamic and other biological variables measured at least @number@ months apart.
Stride cycle time variability was unchanged significantly ( P = @number@ ) .
Stride duration showed a weak linear relationship with age , increasing by approximately @percent@ per year.
Stride duration variability and gait symmetry were also affected by the speech task in older but not younger adults.
STRIDE is a promising interdisciplinary approach to promoting mobility and improving outcomes in hospitalized older adults.
Stride time variability was measured at self-selected pace with a 10m electronic portable walkway ( GAITRite ) .
Striking degeneration of the endoplasmic reticulum ( ER ) was present in the mouse livers at an early stage ( @number@ months old ) .
Strikingly , accumulating evidences indicate that these pathways are involved in both the modulation of the aging process and the control of the clock.
Strikingly , age and refractive errors also had significant impacts on the asymmetry of the corneal shape along the horizontal meridian.
Strikingly , DPCs attenuated osteoclastogenesis when cocultured with primary splenocytes , whereas ABCs slightly but significantly promoted osteoclastogenesis.
Strikingly , EEG results showed an analogous , hyperbolic curve for N1 amplitude , reflecting neural biasing.
Strikingly , mutants blocking acetylation exacerbate α-synuclein toxicity in vivo , in the substantia nigra of rats.
Strikingly , NAP1-like histone chaperones interact with CSB and greatly enhance CSB-mediated chromatin remodeling.
Strikingly , @number@ year after CA , ALA therapy significantly reduced serum markers of inflammation.
Strikingly , only secreted Hsp70 exhibits robust protection against Aβ42-triggered toxicity in the extracellular milieu.
Strikingly , the expression was found to depend on the stimulus frequency with maximum expression at 75Hz.
Strikingly , the regulation by phosphorylation of TERT seems to reveal multiple parallels.
Strikingly , these effects were only in younger T carriers ( < 50 years ) , where aging quells the effects of these genetic factors.
Strikingly , Vps35 overexpression is able to rescue several parkin-mutant phenotypes.
Strikingly , we found a reduction of HACE1 levels in the striatum of Huntington disease patients , implicating HACE1 in the pathology of Huntington disease.
Strikingly , we found no significant effect modification by the MTHFR C677T polymorphism on the Hcy changes after benazepril treatment.
Striking social inequalities were evident , whereby men and those from minority and deprived backgrounds were particularly vulnerable to literacy decline.
Stringent statistical analysis also identified these @number@ miRNAs , and @number@ additional miRNA candidates.
Strip loins from these carcasses were collected , and steaks measuring @number@ cm were fabricated and aged for @number@ or @number@ d postmortem.
Stroke and ADL deficits did not increase.
Stroke and dementia are closely associated , whether in the form of vascular cognitive impairment or Alzheimer's disease.
Stroke and multiple cardiometabolic diseases appear to become less disabling over time , which may partly contribute to the favorable trend in ADL disability.
Stroke and Parkinson disease cause disability and immobilization that increase the risk for fractures.
Stroke can be broadly classified in two major clinical types : ischemic stroke ( IS ) and hemorrhagic stroke.
Stroke ( CHADS2 and CHA2DS2-VASc ) and bleeding ( HASBLED and HEMORR2HAGES ) risk-prediction scores were then applied.
Stroke educational campaigns are used worldwide but there are few published evaluations of such campaigns.
Stroke frequently results in motor impairment.
Stroke incidence was derived from self-report , informant report , and death certificates.
Stroke-induced angiogenesis is similarly regulated by many factors most notably , eNOS and CSE , VEGF / VEGFR2 , and Ang-1 / Tie2.
Stroke is a dramatic event and is associated with potentially severe consequences , including disability , mortality , and social costs.
Stroke is a leading cause of death and the most common cause of long-term disability in the USA.
Stroke is a leading cause of mortality and severe long-term disability worldwide.
Stroke is a life-changing event.
Stroke is a life-threatening disease with limited therapeutic options.
Stroke is a major cause of death and serious neurological disability in older adults in the United States today.
Stroke is an extremely common clinical entity , and poststroke incontinence is a major cause of morbidity for stroke survivors.
Stroke is a serious health problem and is chiefly a disorder of the elderly population.
Stroke is one of the leading causes of death and disability worldwide.
Stroke is one of the leading causes of death in industrialized countries for people older than @number@ years of age.
Stroke is one of the most devastating manifestations of two common diseases , atherosclerosis and hypertension.
Stroke is the largest cause of disability and is third largest cause of mortality in the United States.
Stroke is the second leading cause of death and the third leading cause of disability-adjusted life years.
Stroke may occur at any age ; however , most strokes occur in individuals aged @number@ years and older.
Stroke prevention and treatment remains generic among diabetic patients.
Stroke remains one of the most significant U.S. health problems ( @number@ ) .
Stroke results in disproportionate increase in the risk of dementia when premorbid cognitive functioning is high.
Strokes are the 3rd leading cause of death and reason for disability in Germany and many other countries.
Strokes can themselves generate SDB.
Strokes occurred in @number@ subjects ( @percent@ ) during the follow-up period.
Stroke strongly affects prognosis of patients including quality of life.
Stroke survivors who lived alone were at greater risk for increases in depressive symptoms.
Stroke treatment is effective in reducing mortality and disability , but it is still not available in many areas of the world.
Stroke was associated with increased RR of poststroke dementia ( RR , @number@ @percent@ confidence interval , @number@.80-3.84 ; P < 0.001 ) .
Stroke was induced by unilateral striatal injection of endothelin-1 , the potent vasoconstrictor.
Stromal cells were distinguished according to the presence of vimentin , Factor XIIIa , CD117 , and versican.
Stromelysin-1 ( matrix metalloproteinase-3 : MMP-3 ) occupies a central position in collagenolytic and elastolytic cascades , leading to cutaneous intrinsic and extrinsic aging.
Strong agreement existed between the present sample and previous samples as to the most and least difficult aspects of imprisonment.
Strong associations between ACVR1B genotypes and knee muscle strength ( P-values up to @number@ ) were present.
Strong associations were observed between pain quality and measures of pain severity , interference , and distribution ( P < @number@ ) .
Strong , but indirect evidence suggests that LTL at birth and its attrition during childhood largely explains interindividual LTL variation among adults.
Strong consensus exists regarding the most robust environmental intervention for attenuating aging processes and increasing healthspan and lifespan : calorie restriction ( CR ) .
Strong correlation between early- and adult-life latent factors may have led to a loss in precision when estimating mutually adjusted effects of all periods.
Strong correlation between FS cells and LH cells morphometric parameters might point to age-related interaction between these two cell groups.
Strong correlations between age and strength were not observed.
Strong correlations were observed for men receiving testosterone therapy and for men in the lowest and highest quartiles for total and FT.
Strong cultural values of caring for older adults and a historical tradition of community cooperation may explain this finding.
Strong endorsement from corporate leadership made randomization prior to recruitment feasible with @percent@ participation of facilities randomized to the intervention arm.
Stronger correlations were observed for mental components and the mental scales turned out to be independently related to the TFI in a multidimensional analysis.
Stronger deactivation in the posteromedial cortex with increasing memory load on functional MRI predicted future decline.
Stronger inverse associations were observed in women than in men.
Stronger muscles fatigued more quickly , and slower contractile properties were associated with longer sustained contractions.
Stronger relationships often emerge between mood and memory self-efficacy ( MSE ) than between MSE and memory abilities.
Stronger reward perceptions were associated with higher commitment , investment , and satisfaction , as well as lower quality of alternatives in all studies.
Stronger threat perceptions were also correlated with higher levels of investment and commitment , although these effects did not replicate in our experimental study.
Stronger threat perceptions were associated with lower satisfaction in all @number@ studies.
Strongest enrichment was observed for digestive tissues and immune cell types.
Strong evidence has established the medical and health services utilization benefits of home care services for older adults.
Strong evidence indicates that these two reserves are functionally related.
Strong evidence suggests that systemic inflammation and central adiposity contribute to and perpetuate metabolic syndrome.
Strong friendship bonds and social networking emerge as key features of old lesbian culture.
Strong immunoreactivity to D-β-Asp-containing proteins was observed in subepithelial elastotic lesions and surrounding collagenous lesions from all surgical specimens with pterygia.
Strong interest in stem cell therapies for degenerative diseases has extended to skin aging , itself a degenerative process.
Strong masking deficits are found from an age of about @number@ years on.
Strong mitogenic signaling , such as oncogene activation , also drives cells into a senescent state.
Strong pathophysiological similarities that exist between OSA and AD are underscored here.
Strong primary health care seems to be effective on the population's health outcome.
Strong sex gaps were observed after age @number@ in total body LMI and appendicular LMI ( p < @number@ ) .
Strong SOC may promote good health.
Strontium ranelate is administered orally as a suspension and is generally well tolerated.
Stroop performance was associated with early and with late adaptation in young adults.
Stroop task performance did not differ between groups in all conditions.
Stroop Word and Color-Word performance correlated with higher proportions of Verrucomicrobia and Lentisphaerae.
Stroustrup et al.
Structural acoustical attributes of music defining its treatment effect , are described with the comparison of aspects of rock music and of classical music.
Structural alterations include wide collagen deposition and intravascular reactive oxygen species , and the progression rate with age is steeper.
Structural and functional alterations of vessels accumulate throughout life , culminating in increased risk of developing CVD.
Structural and functional imaging modalities contribute to the diagnosis and understanding of the different dementias.
Structural and functional LC-related measures may provide early AD markers.
Structural and functional magnetic resonance imaging was performed in @number@ early blind ( EB ) humans and @number@ sighted controls ( SC ) .
Structural and functional networks share some of the same characteristics , although their relationship is complex and nonlinear.
Structural and gene expression changes in the microvasculature of the human choroid occur during normal aging and age-related macular degeneration ( AMD ) .
Structural and molecular imaging can now recapitulate the neuropathology of AD antemortem.
Structural and ultrastructural analysis of the myocardial cells revealed reduced myofibrillar content , myofibrillar disorganization , mitochondrial defects and the presence of PolyQ-GFP positive aggregates.
Structural biomarkers for advanced AD stages have not been evaluated yet , being considered only hypothetically.
Structural brain states follow intrinsic dynamics according to a linear system with additional inputs accounting for potential driving forces of brain development.
Structural cerebellar and thalamic damage and posterior cortical alterations are the brain magnetic resonance imaging signatures of C9orf72 MND.
Structural changes due to ischemia and oxidative stress may contribute to prostatic noncompliance in aging men.
Structural changes in critical brain regions may underlie both conditions.
Structural changes in the aging lung superimposed on structural changes due to asthma itself can worsen the disease and physiologic function.
Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal cancer.
Structural changes were categorized to @number@ anatomical categories , and each category was scored from @number@ to @number@ based on severity.
Structural connectivity in white matter pathways , representing the integrity of anatomical connections , underlies the communication between the nodes of these functional networks.
Structural covariance inequality between the Fear of Losses and Physical Appearance factors was shown between males and females.
Structural covariance of the default network scores declined in healthy and pathological aging.
Structural degeneration has been found in the entire cerebral white matter with greatest deterioration in frontal areas , affecting whole brain structural network efficiency.
Structural equation modeling examined latent constructs : emotional distress , age , drug use severity , criminal behavior , gender , and race / ethnicity.
Structural equation modeling indicated that among young and middle-aged adults , increasing family negativity was associated with increases in depressive symptoms over time.
Structural equation modeling ( SEM ) was conducted to test a mediation model.
Structural equation modeling ( SEM ) was used to examine the simultaneous relationships between the variables that comprise the Work Ability Model.
Structural equation modeling using LISREL @number@ was performed to assess the effects of stress , support , and physical activity on mental health.
Structural equation modeling was applied to dissect the observed phenotypic variance into its genetic and environmental components.
Structural equation modeling was completed to examine the strength of the inter-variable relationships.
Structural equation modeling was used to determine relations between AUDs and CUDs across the three developmental periods , and to test for gender differences.
Structural equation modeling was used to estimate the effects of predictor variables on ICT use and the effects of use on depressive symptoms and well-being.
Structural equation modeling was used to estimate the significance of the path coefficients.
Structural equation modeling was used to test an analytic model that focused on the mediating effects of self-perceptions of aging and perceived loss of control.
Structural equation modeling was used to test models with three first-order EF components which included shifting , working memory / updating , and inhibition.
Structural equation modeling was used to test the mediational role of integrity / despair in the relation between forgivingness and depression in both samples.
Structural equation models were used to measure the indirect associations between CVD and @number@ EF task outcomes through a CPS factor.
Structural imaging is limited for early AD detection in the setting of HIV , but proper studies are absent.
Structural magnetic resonance imaging and DTI datasets were acquired from @number@ healthy subjects aged 22-84 years.
Structural magnetic resonance imaging ( MRI ) has been used to compare brain size development , brain structure proportions and brain aging.
Structural magnetic resonance imaging ( MRI ) is a reliable technique used to detect age-related changes in the human brain.
Structural magnetic resonance imaging scans were acquired on a @number@.7T system.
Structural magnetic resonance imaging studies have revealed that the extent of age-related brain changes varies markedly across individuals.
Structural measures of the hippocampus have been linked to a variety of memory processes and also to broader cognitive abilities.
Structural , mechanistic and inhibitor design all contribute to a developing but yet incomplete story of NAMPT function.
Structural modifications in ischemic prostate tissue were similar to those in cells exposed to oxidative stress.
Structural MRI data were segmented and normalized , applying a voxel-based morphometric analysis.
Structural path models suggested that through those age-related changes in Pe amplitude , an indirect effect on the performance was observed.
Structural prediction of MUTYH based on the MutY protein structure allowed us to interpret effects on the protein stability or catalytic activity.
Structural proteins associated with the nuclear envelope play important roles in the organization of the genome.
Structural studies by X-ray crystallography revealed increased electron density surrounding Cys113 following hydrogen peroxide treatment.
Structural studies of matrilin VWA domains will depend on the use of eukaryotic expression systems.
Structural variation has recently been shown to underlie spinocerebellar ataxia types @number@ and @number@
Structure and function of the cardiovascular system are not well understood.
Structure-based analysis reveals that MEF2 dimerization creates a pocket , facilitating S-nitrosylation at an evolutionally conserved cysteine residue in the DNA binding domain.
Structured clinical interviews were conducted to assess PTSD and other psychiatric disorders and childhood trauma exposure.
Structured cognitive assessments were administered at baseline , at @number@ weeks after completion of rTMS , and at @number@ weeks post treatment.
Structure determination of the products was performed by support of chemical ionization MS in positive and negative modes.
Structured inclusion criteria were applied to screen @number@ titles and abstracts to identify @number@ qualitative studies published from @number@ to @date@ .
Structured interview included sociodemographic , lifestyle , health data , and the five alcohol misuse screening questions of the Self-Reporting Questionnaire.
Structured PA may help older adults maintain or increase such routine activities over time.
Structured questionnaires were used to define rhinitis , asthma , and comorbidity , and allergen skin prick tests were used to define atopy.
Structured responses were obtained for living arrangement , marital status , social relationships , and supports.
Structured self-care telephone talks have proved to be successful and a relevant method to use in practice.
Structure , function and breakdown of the blood-brain barrier and the possibilities to cross it , are presented.
Structure-function associations were not significantly different between older and younger subjects.
Structure-function relations also predicted task performance , including accuracy and speed of responding.
Structure-function relationships were investigated using path analyses.
Structures are continuous from the eyelid to the cheek influencing each other during aging.
Structures formed by human telomere sequence ( HTS ) DNA are of interest due to the implication of telomeres in the aging process and cancer.
Structures of the medial temporal lobe ( MTL ) are known to be involved in declarative memory processes.
Structure was evaluated by media-lumen ratio ( M / L ) .
Struggles with independence post-emancipation were common despite adult service use.
ST segment elevation myocardial infarction and non-ST segment elevation myocardial infarction were defined by the presence of certain conditions in reference to the literature.
ST + TT decreased fat mass ( total , central , and extremity ) and increased BioT and LBM versus placebo.
Studentized residuals generated from the model represented the discordance between cognition and pathology , and served as measure of resilience.
Students are mainly aware of the availability of assisted reproductive technologies ( ARTs ) , but overestimate their effectiveness.
Students engaged in one-on-one conversations with healthy older adult mentors and practiced assessment , interviewing and prescription counseling for physical activity and social support.
Students expressed uncertainty as to their ability to make judgements about honest communication with patients with dementia and their families.
Students from all disciplines sought online materials that are interactive , engaging , case-based and locally relevant.
Students in an undergraduate applied research in aging class learned about qualitative research methods by analyzing previously collected narratives.
Students submitted to educational strategies were compared against students with no intervention.
Student's test was used for univariate analysis and regression analysis models was used for multivariate analysis.
Student's t-test and ANOVA were used for quantitative variables by categories and regression for linear relationships.
Student's t-test and chi-squared test were used for data analysis as appropriate.
Student's t test and chi-square test were used to compare ferritin levels and Body Mass Index , respectively , between sexes.
Student's t-test and Pearson's correlation coefficient ( r ) values were calculated.
Student's t-tests for paired samples and repeated measures ANOVA were used to compare dependent variables , and statistical significance was set at P < 0.05.
Student's t-tests were performed to compare characteristics of CIND and non-CIND individuals ; data from male and female participants were analyzed separately.
Student's t tests were used to analyse the data.
Student's t tests were used to compare costs per treatment between the two groups.
Student's t-tests were used to select the components displaying significant group difference for a more purposed analysis.
Students were able to distinguish between different waveforms of blood flow within different age groups.
Student-teacher relationship quality was moderately stable for the typical development group , but less so for the intellectual disability group.
Student-teacher relationships in the intellectual disability group were significantly lower for children in regular than special classes by age @number@
Student-teacher relationships of @number@ children with moderate to borderline intellectual disability and @number@ with typical cognitive development were assessed from child ages 6-8 years.
Student t test and multiple logistic regression analysis were used to compare the absolute and relative values of the TT-TG distance between patients and controls.
Studies about risk factors for epilepsy during MS are heterogeneous.
Studies accounting for this over-adjustment suggest that age is , in fact , independently associated with mortality in hospitalized patients with CAP.
Studies across neurological traits have shown that younger-onset cases have an increased genetic burden.
Studies addressing immunosenescence in the immune system have expanded to focus on the innate as well as the adaptive responses.
Studies addressing telomere shortening in rheumatic diseases so far yielded controversial results.
Studies aiming at identifying the factors , which are responsible for these changes during the individual's life , are still needed.
Studies also indicate that plasma apoE levels may reflect disease status , suggesting that apoE is a potential AD biomarker.
Studies also indicate that telomerase activity in epidermal stem cells might have roles that go beyond telomere elongation.
Studies also suggest that essential amino acids stimulate muscle protein synthesis to a greater extent than nonessential amino acids.
Studies are largely limited by varying inclusion criteria , as well as differences in pathological classification schemes.
Studies are needed that evaluate whether sleep variables are associated with neuroimaging evidence of β-amyloid ( Aβ ) deposition.
Studies are needed to clarify the mechanisms of these associations and their implications for functional outcomes.
Studies are needed to evaluate the benefit of early detection of CKD and treatment to decrease these deaths.
Studies are needed to examine whether APOE promotes AD by degrading sleep and to clarify the role of race in these associations.
Studies are required to determine the prognostic value of MBI for dementia development , and for predicting different dementia subtypes.
Studies assessing energy expenditures documented that the majority of gardening tasks were classified into low-to-moderate intensity physical activity.
Studies assessing satisfaction illustrated a high level of satisfaction for the majority of patients.
Studies assessing the association between AC-drug use and health-related quality of life ( HRQoL ) show conflicting results.
Studies based on any type of dementia patient were combined and analyzed by subgroup.
Studies concerning post-surgery rehabilitation , case studies , and articles that did not measure primary results were excluded.
Studies concerning the determinants of shared decision-making mostly focused on non-modifiable factors.
Studies concerning the pharmacokinetics and dynamics of sufentanil administered as a bolus or continuous infusion in children are few.
Studies confirm the efficacy of these topical agents in combination with superficial and / or medium depth or deep peeling agents for photodamaged skin treatment.
Studies consistently show that increasing levels of socioeconomic status ( SES ) and having a familial history of longevity reduce the risk of mortality.
Studies describing normal healthy subjects and observational studies that used control groups as a comparison were included.
Studies designed to further delineate whether training-induced changes in cognitive function could contribute to dual-task gait improvements and falls reduction , remain to be conducted.
Studies detailing the methodology of the conversion methods and the strategies and approach for the development of these novel drug delivery systems are described.
Studies did not use consistent , valid and reliable instruments.
Studies documenting the barriers experienced to antipsychotic discontinuation are rare.
Studies documenting the role of these variables would be useful.
Studies done focused on assessing COX-2 expression after acute ultraviolet exposure and in photocarcinogenesis.
Studies dysfunction in accelerating aging.
Studies evaluating integrated general medical and psychiatric self-management interventions for adults with schizophrenia spectrum or mood disorders and general medical comorbidity were included.
Studies evaluating MIP have noted its positive impact on financial protection , but find only a marginal impact on improved access.
Studies evaluating the association of canities with osteopenia and cardiovascular disease have revealed mixed results.
Studies evaluating the natural history and conservative treatment modalities of cSDH remain sparse and are predominantly of low level of evidence.
Studies examined the effects of medication on @number@ mA tDCS delivered to M1 ( motor ) and orbit / supraorbital ( SO ) area.
Studies examining differential intervention effects by at least one PROGRESS-Plus factor were quality assessed.
Studies examining the relationship of myosteatosis and mortality among older individuals recruited without regard to their health status are sparse.
Studies exploring the impact of early intervention for these risk factors on hippocampal integrity are warranted.
Studies from the 1990s estimated mortality of ICH to be as high as @percent@.
Studies from yeast have suggested that in addition to altered nucleotide transport properties , the mutant proteins cause a global stress on the inner membrane.
Studies had to report an underpinning theory and measure at least one adherence and one clinical / humanistic outcome.
Studies have already linked the circadian clock to the control of UVB-induced DNA damage and skin cancers.
Studies have also examined risk factors and impact of urinary incontinence , including lifestyle , comorbidities and medications.
Studies have also shown significant urban-rural differences in access to healthcare in developing countries such as China.
Studies have assessed IMF content , using the mid-thigh as a representative location.
Studies have been conducted with scars in various parts of the body and further research is ongoing.
Studies have compared echocardiography and CMRI for diagnosing diastolic dysfunction in small patient groups with similar results.
Studies have convincingly shown that both physical and mental activity are positively associated with cognitive task performance in aging.
Studies have demonstrated a direct correlation between telomere length and life expectancy , stress , DNA damage , and onset of aging-related diseases.
Studies have demonstrated a significant correlation between several genes involved in the metabolic pathway of insulin and environmental factors.
Studies have demonstrated that an increase in rectus femoris EI may affect physical performance.
Studies have demonstrated that PSP can present clinically as an atypical dementing syndrome dominated by a progressive apraxia of speech ( AOS ) and aphasia.
Studies have found that statins also play a positive role in periodontitis treatment.
Studies have implicated the sirtuins ( SIRT1-SIRT7 ) as mediators of key effects of caloric restriction during ageing.
Studies have indicated telomere length as a biomarker for biological aging.
Studies have indicated that there may be a smoking-dependent association between skin wrinkling and airflow obstruction of the lung.
Studies have linked neurogenesis to the beneficial actions of specific antidepressants.
Studies have not investigated the relationship between self-rated health and risk of ET.
Studies have recently identified certain factors that may contribute to maintaining the cognitive health of seniors.
Studies have related human lifespan as being 25-32 % due to genetic polymorphisms between individuals associated to longevity and aging.
Studies have reported an increased risk of developing diabetes in subjects receiving statins versus placebo.
Studies have reported that older females have impaired heat loss responses during work in the heat compared to young females.
Studies have shown a clear association between gait and cognition.
Studies have shown a higher risk of peri-prosthetic joint infections ( PJI ) in HIV patients.
Studies have shown an association between iron deficiency without anemia and adverse effects on psychomotor development.
Studies have shown differences in specific cognitive ability domains and risk of Alzheimer's disease between the men and women at later age.
Studies have shown inhibition of early and late autophagy in cells cultured in medium treated with zinc chelators.
Studies have shown protective effects of resveratrol against ultraviolet radiation-mediated oxidative stress and cutaneous damages including skin cancer.
Studies have shown reactive oxygen species ( ROS ) type free radicals are linked to skin cancer and aging.
Studies have shown that an integrated model of care for the elderly can improve the quality of patient care and outcomes.
Studies have shown that exercise programs including balance training and resistance training are effective in preventing falls.
Studies have shown that factors such as food choices , physical activity , and screen time play important roles in fostering obesity.
Studies have shown that low HGS is associated with common age-related disorders including frailty and sarcopenia.
Studies have shown that older and younger adults differ in how they respond to reminders of their mortality.
Studies have shown that oncogene-induced senescence function as a barrier to neoplastic transformation.
Studies have shown that the number of elderly burn patients has reached @percent@ to @percent@ of the total number of burn patients.
Studies have shown that white matter ( WM ) volumetric reductions and overall degradation occur with aging.
Studies have shown that women have worse postural balance and greater functional dependence than men , but there is no consensus regarding this.
Studies have suggested a link between Sirt1 and circadian rhythms , the disruption of which has been linked to cancer.
Studies have suggested that dental development substantially influences the variation of mandibular morphology and growth in primates.
Studies have suggested that telomere shortening may be associated with aging related diseases and also psychiatric disorders.
Studies have suggested that the quality of dietary intake may affect the development of frailty.
Studies highlight satisfaction with life as a predictor of quality of life and has a marked correlation with a decrease in functionality.
Studies identifying optimal dosing for proteins and amino acids are not currently available.
Studies in animal models have demonstrated beneficial effects on glucose metabolism , vascular function and anti-inflammatory and antioxidant properties.
Studies in areas of high malaria transmission have shown that asymptomatic individuals infected with multiclonal infections are at reduced risk of febrile malaria during follow-up.
Studies in cancer models suggest that sunitinib might also modulate autophagy , which is dysregulated in our models of Tat-induced neurotoxicity.
Studies including hospitalized patients with a mean age≥65years , describing change of hand grip strength and / or muscle mass were found eligible.
Studies indicate that hippocampal atrophy has functional consequences , e.g. cognitive impairment.
Studies indicate the involvement of brain-derived neurotrophic factor ( BDNF ) in the pathogenesis of Alzheimer's disease ( AD ) .
Studies in dopamine-related polymorphisms have focused on associations with neuroleptic-induced movement disorders.
Studies in emerging mouse models of ALS are therefore warranted to further explore the potential of SMN as a modifier of ALS.
Studies in flies , worms , yeast , and mice support the notion that the TOR signaling network modulates aging.
Studies in genetic mouse models provided evidence that cell death could cause inflammation in different tissues.
Studies in humans have shown that muscle mechanoreflex activation inhibits cardiac vagal outflow , decreasing the sensitivity of baroreflex control of HR.
Studies in humans suggest that leukocyte telomere length may act as a marker of biological aging.
Studies in invertebrate model organisms have led to a wealth of knowledge concerning the ageing process.
Studies in invertebrates , particularly Caenorhabditis elegans , have uncovered numerous genes involved in aging , many conserved in mammals.
Studies in mammals have demonstrated that hyperglycemia and hyperinsulinemia are important factors in aging and cancer.
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging.
Studies in mice implicate loss of chromosome cohesion as an important cause of age-related meiotic errors in the oocyte.
Studies in model organisms suggest that changes in signaling can augment these critical stress response systems , increasing life span and reducing age-related pathology.
Studies in mouse models showed that sensitization of keratinocytes to apoptosis or necroptosis triggered by TNF and other stimuli causes severe chronic inflammatory skin lesions.
Studies in mutant mice targeting various lipid biosynthesis pathways have shown that myelinating glia have a remarkable capacity to compensate the lack of individual lipids.
Studies in neuronal cells subjected to oxidative stress , mimicking such stress in AD brains , are therefore of great interest.
Studies in older persons with HF and frailty have shown a non-statistically lower mortality rate compared to those receiving placebo.
Studies in pregnant women show satisfactory results.
Studies in several animal prototypes of brain injury suggest that RESV is an effective neuroprotective compound.
Studies in simple model organisms demonstrate that pharmacological substances , genetic interventions and dietary restriction can slow down the process of aging.
Studies in STZ-DM rodents show that cellular processes underlying synapse strengthening or weakening are not altered.
Studies in the healthy elderly suggest that DHA homeostasis changes during aging.
Studies in the yeast Saccharomyces cerevisiae have provided valuable insights into the mechanisms of cellular dysfunction associated with the expression of faulty PD genes.
Studies in transgenic mice have suggested a number of possible anti-inflammatory approaches but they may not always be a good model.
Studies investigating multiple pain sites found the lower limb and the spine to be the most prevalent complaints ( @percent@ each ) .
Studies investigating the relation between lycopene and PCa risk have produced inconsistent results.
Studies investigating the relationship between the ACE-insertion / deletion ( I / D ) gene polymorphism and myocardial infarction ( MI ) have been inconsistent.
Studies involving diffusion tensor imaging ( DTI ) of amyotrophic lateral sclerosis ( ALS ) with whole-brain voxel-based analysis yielded variable findings.
Studies involving neurobiological correlates such as neuroimaging and biomarkers have presented distinct results.
Studies in which LD was measured by dual-energy x-ray absorptiometry or by abdominal computed tomography or magnetic resonance imaging scan only , were included.
Studies in young adults indicate that past and future thinking share common cognitive and neural underpinnings.
Studies manipulating emotional valence in prospective memory ( PM ) have so far revealed inconsistent results.
Studies measuring mental health outcomes have shown decreases in anxiety , and increases in cognitive performance after yoga interventions.
Studies of AIH in elderly patients have been fairly limited.
Studies of diffusion tensor imaging have focused mainly on the role of deep white matter tract microstructural abnormalities associated with aging and age-related cognitive decline.
Studies of diverse species have revealed that chromatin undergoes extensive rearrangements during aging.
Studies of estrogen and the heart span human clinical trials and basic cell and molecular investigations.
Studies of exceptionally long-lived individuals show that heritability is greatest at the oldest ages.
Studies of head size and brain volume in autism spectrum disorders have suggested that early cortical overgrowth may be followed by prematurely arrested growth.
Studies of healthy aging over the entire life spectrum promise valuable normative data for age-specific assessments of health and the setting of realistic health goals.
Studies of human type @number@ diabetic islets underline that these miRNA families could have important roles also in human type @number@ diabetes.
Studies of implicit memory for novel associations have focused primarily on verbal materials and have highlighted the contribution of conceptually unitized representations to such priming.
Studies of miRNAs and their interactions with SNPs could provide further insights into the mechanisms of prostate cancer risk.
Studies of Nordic twins suggest an increased genetic influence on mortality with age.
Studies of nutritional interventions should consider using MRI atrophy rather than cognition as outcome.
Studies of OCD have found a close correlation between clinical symptoms , cognitive function , and brain function.
Studies of oxidative damage during the progression of Alzheimer's disease ( AD ) suggest its central role in disease pathogenesis.
Studies of racial residential segregation have found that black-white segregation in U.S. metropolitan areas has declined slowly but steadily since the early 1970s.
Studies of recognition typically involve tests in which the participant's memory for a stimulus is directly questioned.
Studies of skin aging are usually performed at the genomic level by investigating differentially regulated genes identified through subtractive hybridization or microarray analyses.
Studies of subjects free of neurologic disease at baseline , with or without mild memory complaints ( MMC ) , were included.
Studies often involve small numbers of subjects , and design may be sub-optimal in other respects.
Studies of the aging process especially those involving the comparison of long-lived individuals and young controls are fairly limited.
Studies of the microbiota in older people might tell us which probiotics could increase longevity.
Studies of the older autistic brain may not address original causes but are essential to discovering how best to help the older aging autistic person.
Studies of theory of mind ( ToM ) abilities in older age groups have yielded mixed results.
Studies of the risk of incident dementia in the population with stroke compared with the population without stroke were identified and compared.
Studies of this nature in women are difficult , and often unethical to conduct.
Studies of very old adults to quantify the role of PA in reducing dementia burden via WM integrity are warranted.
Studies of women with type @number@ diabetes are inconsistent but suggest increased anovulation and earlier menopause.
Studies on age-shift ( morning , afternoon , night ) and age-shift system ( roster ) interactions were also reviewed.
Studies on cognitive impairment could not be pooled due to large heterogeneity.
Studies on decision making have come to challenge the idea that having more choice is necessarily better.
Studies on frequency / volume of weight training and WC change are warranted.
Studies on in vitro tau aggregation show that tau forms two different intermediate aggregates called tau oligomers and granular tau oligomers before forming fibrils.
Studies on large informative families are advisable to better define how genetics and non genetics factors like exercise and diet may influence the clinical phenotype.
Studies on longer-term outcomes , including cervical cancer and the emergence of new viral genotypes are also necessary.
Studies on mice to uncover the cellular and molecular changes underlying neural connectivity have found effective changes in brain networks after learning or training.
Studies on normal aging have identified a molecular circuit in which the dysfunction of telomeres caused by cellular aging activates the TP53 gene.
Studies on outcome evaluation suggest positive outcomes of OTC devices in the elderly population.
Studies on pomegranate peel have revealed antioxidant , anti-inflammatory , anti- angiogenesis activities , with prevention of premature aging and reducing inflammation.
Studies on progeroid syndromes have suggested that the DNA damage response is involved in regulation of metabolic homeostasis.
Studies on the association of T2DM and mild cognitive impairment ( MCI ) are rare.
Studies on the prevalence of symptoms in the general population and its ' relation to LS in the oldest-old are to our knowledge non-existent.
Studies on the processes of blood cell formation have revealed several shortcomings as a consequence of chronological age.
Studies on the relation between environmental factors and PA should consider adjustment for weather factors.
Studies on these subjects , and concerning men aged @number@ years or older , were eligible for inclusion in this review.
Studies on the shortage of village doctors , mainly based on the national statistics , have so far been very broad.
Studies performed to date have provided us with some clues that can help orient clinicians in taking the most appropriate course of action.
Studies primarily focused on nurse assisted home care patients and mostly examined PD related clinical outcomes.
Studies published in English , Italian , French , Portuguese , and Spanish were considered for inclusion in the review.
Studies published so far have been case-control studies and hence vulnerable to bias introduced by cohort effects.
Studies relating differential methylation with intermediate phenotypes and disease endpoints may be useful in identifying additional candidate genes and mechanisms involved in disease.
Studies reporting an incidence rate for GCA were used to model disease incident cases at regional and national levels.
Studies reveal that communication with one's circle is therefore often arduous , leading us to believe that it can cause suffering.
Studies reveal that MMPs and the tissue inhibitors of metalloproteinases ( TIMPs ) play pivotal roles in pathogenesis and recovery of neurons.
Studies show an association between eveningness and depression.
Studies show a positive association between pulmonary function and the cognitive performance of individuals from middle age on.
Studies show that ambient temperature and air pollution are associated with cardiovascular disease and that they may interact to affect cardiovascular events.
Studies show that the blood-brain barrier is altered in animal models of epilepsy and in epileptic patients.
Studies solely involving pediatric populations , or addressing spinal conditions of nondegenerative causes , were excluded.
Studies specifically designed for elderly patients are rare.
Studies suggest frailty occurs earlier in HIV-infected individuals , but data in postmenopausal HIV-infected women are lacking.
Studies suggest improvements of neurocognitive function among older adults who undergo aerobic exercise training.
Studies suggesting that imaging biomarkers of neurodegeneration are independent of amyloid-β give rise to new hypothesis regarding the pathological cascade in Alzheimer's disease.
Studies suggest that aging affects the sensory re-weighting process , but the neuroimaging evidence is minimal.
Studies suggest that a large proportion of adults do not manage to save enough for retirement.
Studies suggest that cumulative exposure to lead , as measured in the bone , is associated with accelerated cognitive decline at older age.
Studies suggest that ER stress facilitates fibrotic remodeling through activation of pro-apoptotic pathways , induction of epithelial-mesenchymal transition , and promotion of inflammatory responses.
Studies tend to focus on the neurotoxicity of specific Aβ species.
Studies testing the effectiveness of GnRH antagonists in controlled ovarian stimulation ( COS ) for intrauterine insemination ( IUI ) have provided controversial results.
Studies that examined polypharmacy or specific drugs were excluded.
Studies that explore the potential determinants of hearing-aid usage were to be included.
Studies that include large samples are needed to further evaluate the psychometric properties of the USE-PAP.
Studies that reported on the use of nutritional supplementations and / or populations with significant cognitive impairment were excluded.
Studies that specifically target diabetes management in older population are lacking and those that target diabetes management in the long-term care facilities are even fewer.
Studies that verify this latter outcome are needed , as are studies designed to elucidate the mechanisms of fatigue.
Studies to date indicate that change in performance with ageing is largely environmentally mediated , with little contribution from genetics.
Studies used theory across the intervention trajectory.
Studies using fMRI have reported that lower task-based activity in the prefrontal cortex and limbic regions was associated with poorer outcome.
Studies using functional near infra-red spectroscopy ( fNIRS ) reported inconsistent findings of brain activation age-related changes in response to increased task demands.
Studies using human PBMC or isolated monocytes confirmed potentiation of TNF-α production with different TLR agonists , while interleukin ( IL ) -10 was inhibited.
Studies using inulin , Cr-51-EDTA , Tc-DTPA or iohexol assays as the gold standard were included.
Studies using various MSC subpopulations and models have led to discrepant results.
Studies varied by use of objective , self-report , and a combination of outcome measures with a greater number reporting only subjective measures of adherence.
Studies were also obtained through reference mining.
Studies were also required include at least one objective measure of physical function as a dependent outcome.
Studies were assessed for methodological quality.
Studies were assessed for suitability , then reviewed with data extracted , and grouped by categories of outcome measures.
Studies were eligible if they included data on non-transportation rates , information on outcomes or alternate care pathways for older people who have fallen.
Studies were graded using the American Association of Critical Care Nurses ' ( AACN ) level of evidence.
Studies were grouped into @number@ following categories : routine geriatric consultation , geriatric ward with orthopaedic consultation , and shared care.
Studies were grouped into three major themes for review : men's experiences of caregiving , relational factors , and outcomes of caregiving.
Studies were heterogeneous in design and methodology.
Studies were heterogeneous in methodology and results were not consistent.
Studies were heterogeneous with respect to case numbers , control types and adjustment for covariates.
Studies were identified from a systematic search across major electronic databases from inception as @date@ .
Studies were identified from MEDLINE and EMBASE databases from inception to @date@ .
Studies were limited to those conducted in the United States and published in English between @number@ and @number@
Studies were only included if patients had an official diagnosis and were in the early stages of dementia.
Studies were pooled in homogenous prevalence groups and factors that differed across groups were ascertained.
Studies were pooled using the generic inverse variance method and both fixed and random effects models.
Studies were reviewed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses ( PRISMA ) guidelines.
Studies were screened for inclusion or exclusion using a priori criteria and , once identified , studies were examined for quality using pre-specified criteria.
Studies were then selected in a systematic fashion using specific predetermined criteria.
Studies which report no effect of phytoestrogens on cognition have mainly been carried out in European cohorts , with an average low dietary consumption.
Studies with a larger sample size and conducted over longer periods should be performed.
Studies with even longer observation periods are needed to evaluate the ultimate effect of BP on kidney function.
Studies with large number of cases and longer follow-up time are needed to validate our results.
Studies with monoclonal antibodies have been disappointing , highlighting the tendency for infections and malignancies during treatment.
Studies with only a home training intervention and those without an applied research component were excluded.
Studies without suitable data for meta-analysis were summarized separately.
Studies worldwide have identified that some older patients with good appetites do not receive sufficient nourishment because of inadequate feeding assistance.
Study 2 : @number@ medical or surgical patients.
Study 2 : There were @number@ ACs ( age : 23-51 yr ) who volunteered for trials during late shifts at an international airport.
Study adherence was @percent@ , with @percent@ of subjects maintaining @percent@ or greater adherence.
Study adherence was unexpectedly high.
STUDY AIM : To characterize the interaction between gigantol extracted from D. chrysotoxum Lindl and the AR gene , and determine gigantol's efficacy against cataractogenesis.
Study and analysis of the distribution level DC-potential brain mapping was carried out by the measured values of monopolar constant potentials.
STUDY APPRAISAL AND SYNTHESIS METHODS : A systematic review of population-based articles published up until @date@ , is presented.
STUDY APPRAISAL AND SYNTHESIS METHODS : Determination of relevance and data extraction was performed independently by two reviewers.
STUDY APPRAISAL AND SYNTHESIS METHODS : Risk of bias was systematically assessed by using the Cochrane risk of bias tool.
STUDY APPRAISAL AND SYNTHESIS : Risk of bias was systematically assessed independently by both authors using the Cochrane risk of bias tool.
Study appraisal included a thorough risk of bias assessment.
Study characteristics and results were extracted and dose-response relationships were graphically displayed in a standardised manner.
Study Code Daylight 01.
Study collection began in @date@ .
Study criteria yielded a final sample of @number@ women with @number@ observations.
Study data included responses to open-ended prompts asking participants to describe one positive experience and one negative experience caring for a dying patient.
STUDY DESIGN : A descriptive study of the association between diffuse idiopathic skeletal hyperostosis ( DISH ) and kyphosis.
STUDY DESIGN : A histological , biological , and immunohisto-chemical study of human lumbar ligamentum flavum.
STUDY DESIGN : A histological study on degenerative changes in cervical IVDs and EPs was conducted.
STUDY DESIGN : A kinematic magnetic resonance imaging study.
STUDY DESIGN : A Medline search was performed on rejuvenation of the chest from @number@ to @number@
STUDY DESIGN : An anatomic observational study.
STUDY DESIGN AND METHODS : Data were drawn from a prospective , observational cohort study of morbidity outcome in patients undergoing cardiac surgery.
STUDY DESIGN AND METHODS : RBCs were processed and stored according to Australian blood banking guidelines.
STUDY DESIGN AND METHODS : RBCs were processed and stored following standard Dutch blood bank procedures.
STUDY DESIGN AND METHODS : SAGM-RBCs were prepared from mixed and split pairs ( n = @number@ ) of WB units.
STUDY DESIGN AND METHODS : Ten units of RBCs were stored for @number@ days.
STUDY DESIGN AND SETTING : Lifelines is a cross-sectional population-based Dutch cohort study.
STUDY DESIGN AND SETTING : We illustrate and quantify the expected bias using cancer registry data from the United States.
STUDY DESIGN : An electronic search of PubMed and Chinese Biomedicine databases was conducted to select studies.
STUDY DESIGN : An electronic search of PubMed and Chinese Biomedicine database was conducted to select studies for meta-analysis.
STUDY DESIGN : An observational , cross-sectional cohort design was used with a sample of @number@ elderly Japanese citizens living in a community setting.
STUDY DESIGN : A prospective clinical study.
STUDY DESIGN : A prospectively designed multicenter observational study using data from the Canadian Kidney Disease Cohort Study ( CKDCS ) .
STUDY DESIGN : A prospective , population-based 15-year follow-up study of the age cohort of 70-year-olds living in the city of Turku , Finland.
Study Design A retrospective case-control study.
STUDY DESIGN : A retrospective radiographic study.
STUDY DESIGN : A retrospective radiographic study.
STUDY DESIGN : A retrospective single-center study.
STUDY DESIGN : Cadaver study.
STUDY DESIGN : Case-control histopathologic human temporal bone study.
STUDY DESIGN : Case control study ; Level of evidence , @number@
STUDY DESIGN : Case series.
STUDY DESIGN : Case series.
STUDY DESIGN : Case series ; Level of evidence , @number@
STUDY DESIGN : Case series ; Level of evidence , @number@
STUDY DESIGN : Cervical decompression ( CD ) and cervical fusion ( CF ) patients in @percent@ Medicare Part B claims data.
Study design characteristics , fiber exposures , and outcome categories were summarized.
STUDY DESIGN : clinical prospective.
STUDY DESIGN : Cohort imaging study.
STUDY DESIGN : Cohort study.
STUDY DESIGN : Cohort study.
STUDY DESIGN : Cohort study ; Level of evidence , @number@
STUDY DESIGN : Cohort study ; Level of evidence , @number@
STUDY DESIGN : Comparison between two groups of different age ranges.
STUDY DESIGN : Consecutive case series.
STUDY DESIGN : Controlled laboratory study.
Study Design Controlled laboratory study , cross-sectional.
STUDY DESIGN : Cross-sectional.
STUDY DESIGN : Cross-sectional.
STUDY DESIGN : Cross-sectional.
STUDY DESIGN : Cross-sectional.
STUDY DESIGN : Cross-sectional.
STUDY DESIGN : Cross-sectional analysis.
STUDY DESIGN : Cross-sectional analysis of a national database.
STUDY DESIGN : Cross-sectional analysis of a national database.
STUDY DESIGN : Cross-sectional analysis of a national database.
STUDY DESIGN : Cross-sectional analysis of observational data collected in the Baltimore Longitudinal Study of Aging.
STUDY DESIGN : Cross-sectional analysis of the Baltimore Longitudinal Study of Aging , a prospective cohort study.
STUDY DESIGN : Cross-sectional cohort study.
STUDY DESIGN : Cross-sectional @number@ and @number@ National Health Interview Survey data were used.
STUDY DESIGN : Cross-sectional observational clinical trial.
STUDY DESIGN : Cross sectional , observational study.
Study Design Cross-sectional study.
STUDY DESIGN : Cross-sectional study.
STUDY DESIGN : Cross-sectional study.
STUDY DESIGN : Cross-sectional study.
STUDY DESIGN : Cross-sectional study.
STUDY DESIGN : Cross-sectional study.
STUDY DESIGN : Cross-sectional study.
STUDY DESIGN : Cross-sectional study.
STUDY DESIGN : Cross-sectional study.
STUDY-DESIGN : Cross-sectional study.
STUDY DESIGN : cross-sectional study in @number@ community-dwelling older people aged ≥65 years.
STUDY DESIGN : Cross-sectional study of auricular and septal cartilage from @number@ fresh cadavers.
STUDY DESIGN : Cross-sectional study with @number@ elderly healthy females with no history of voice problems.
STUDY DESIGN : Cross-sectional survey.
STUDY DESIGN : Cross-sectional survey.
STUDY DESIGN : Data were reviewed from consecutive patients who had laparoscopic surgery for endometrial cancer staging in @number@ Italian centers.
STUDY DESIGN : Decision-tree analysis.
STUDY DESIGN : Demographics , diagnoses , surgical treatments , and postoperative outcomes of patients who underwent major hepatic resection were reviewed.
Study Design Descriptive , cross-sectional.
STUDY DESIGN : Descriptive , laboratory study.
STUDY DESIGN : Descriptive laboratory study.
STUDY DESIGN : ECG was recorded using a PBSM , and the maximum entropy of ECG every @number@ RR intervals was calculated.
STUDY DESIGN : Economic analysis of SHPT treatment in hemodialysis patients.
STUDY DESIGN : Forty-nine subjects received a total of two radio-frequency treatments to the face and neck one-month apart.
STUDY DESIGN : In a prospective comparative study , we enrolled @number@ infertile women with uterine septum as a sole cause for reproductive failure.
STUDY DESIGN : Information on the mode of death was obtained from first-degree relatives and / or health personnel of a local health office.
STUDY DESIGN : Interventional , comparative , split face clinical trial.
STUDY DESIGN : It is a retrospective study on otherwise healthy post-menopausal women.
STUDY DESIGN : Ligamentum flavum ( LF ) thickness was measured by using lumbar magnetic resonance imaging in patients with low back or leg pain.
STUDY DESIGN : Longitudinal cohort.
STUDY DESIGN : Longitudinal cohort study of community-resident people born in @number@ and assessed at mean ages of @number@ @number@ and @number@ years.
STUDY DESIGN : Longitudinal random effects modelling.
STUDY DESIGN : Longitudinal study.
STUDY DESIGN : Longitudinal study with postal survey.
STUDY DESIGN / MATERIALS AND METHODS : One fractional CO2 laser procedure was performed on the full face in @number@ patients with photoaging.
STUDY DESIGN : Meta-analysis.
STUDY DESIGN : Narrative overview of the focus issue on cervical spondylotic myelopathy ( CSM ) .
STUDY DESIGN : Observational.
STUDY DESIGN : Observational population-based study.
STUDY DESIGN : Observational study with a cross-sectional design.
STUDY DESIGN : Patients ( n = @number@ ) with temporomandibular disorders ( age , @number@ to @number@ years ) underwent clinical and radiographic examinations.
STUDY DESIGN : Pelvic morphology was evaluated in a normal adult population by measuring the anatomical parameters of sagittal pelvic alignment.
STUDY DESIGN : Pilot cross-sectional clinical measurement.
STUDY DESIGN : Pooled data from three 12-week , randomized , double-blind , parallel-group , multicentre trials.
STUDY DESIGN : Post hoc analysis of pooled data from two 12-week randomized , placebo-controlled studies.
STUDY DESIGN : Postmenopausal women with dyspareunia were enrolled in this study.
STUDY DESIGN : Prospective.
STUDY DESIGN : Prospective.
STUDY DESIGN : Prospective cohort study.
STUDY DESIGN : Prospective cohort study.
STUDY DESIGN : Prospective experimental.
STUDY DESIGN : Prospective group design.
STUDY DESIGN : Prospective interventional study.
STUDY DESIGN : Prospective , multicenter study.
STUDY DESIGN : Prospective observational and analytic study.
STUDY DESIGN : Prospective observational cohort study.
STUDY DESIGN : Prospective observational cohort study.
STUDY DESIGN : Prospective , randomized , controlled.
STUDY DESIGN : Prospective study.
STUDY DESIGN : Prospective study of normal sagittal global spinal balance in the Caucasian adult population.
STUDY DESIGN : Prospective translational experiment.
STUDY DESIGN : Qualitative research.
STUDY DESIGN : Qualitative semi-structured interviews conducted with a self-selecting sample of retired people.
STUDY DESIGN : Qualitative study involving in-depth interviews.
STUDY DESIGN : Randomized controlled trial ; Level of evidence , @number@
STUDY DESIGN : Randomized parallel group controlled trial.
STUDY DESIGN : Retrospective.
STUDY DESIGN : Retrospective chart review.
STUDY DESIGN : Retrospective chart review of patients evaluated from @number@ to @number@
STUDY DESIGN : Retrospective chart review of patients treated with bilateral thyroplasty and / or injection augmentation.
STUDY DESIGN : Retrospective , clinical review.
STUDY DESIGN : Retrospective cohort study.
STUDY DESIGN : Retrospective cohort study.
STUDY DESIGN : Retrospective cross-sectional chart study of @number@ children ( ages @number@ to @number@ years ) followed at an A-T clinic.
STUDY DESIGN : Retrospective database review.
STUDY DESIGN : Retrospective data collection study.
STUDY DESIGN : Retrospective observational study.
STUDY DESIGN : Retrospective review.
STUDY DESIGN : Retrospective review of data on patients who underwent laparoscopic sacropexy in two tertiary centers.
STUDY DESIGN : Retrospective study.
STUDY DESIGN : Retrospective study.
STUDY DESIGN : Retrospective study comparing ScoliScore and clinical risk estimates.
STUDY DESIGN : Retrospective , survey-weighted , cohort analysis of the @number@ Medicare Current Beneficiary Survey Cost and Use files.
STUDY DESIGN : Scoping review.
STUDY DESIGN : Secondary analysis using regression analysis to predict the outcome.
STUDY DESIGN / SETTING : An in vitro study.
STUDY DESIGN / SETTING : Review article.
STUDY DESIGN / SETTING : This cross-sectional study was conducted in a laboratory.
STUDY DESIGN , SIZE , DURATION : A cross-sectional study was performed in @number@ post-menopausal women with , and @number@ post-menopausal women without , diabetes.
STUDY DESIGN , SIZE , DURATION : A multicenter , cross-sectional study was performed between @date@ and @date@ in @number@ women.
STUDY DESIGN , SIZE , DURATION : An online cross-sectional survey of Chinese university students in Hong Kong was conducted in @number@
STUDY DESIGN , SIZE , DURATION : A retrospective cohort study was performed with @number@ women who visited the outpatient clinic between @number@ and @number@
STUDY DESIGN : Study participants completed structured , in-person interviews administered by trained research assistants.
STUDY DESIGN : Systematic review.
STUDY DESIGN : Systematic review.
STUDY DESIGN : Systematic review and effectiveness analysis.
STUDY DESIGN : Systematic review and meta-analysis.
STUDY DESIGN : Systematic review and thematic synthesis of qualitative studies.
STUDY DESIGN : The QI set was developed based on the ACOVE QIs , Dutch national guidelines , evidence from the literature and expert opinion.
STUDY DESIGN : The study included @number@ male subjects ( mean age @number@.6±11.3 years ) presenting to our department for cardiologic evaluation.
STUDY DESIGN : The study was performed at the Institute of Obstetrics and Gynecology , University of Modena , between @date@ and @date@ .
STUDY DESIGN : The thickness of @number@ skulls of Thai population was measured at the areas where halo pins are placed.
STUDY DESIGN : Thirty-three subjects performed @number@ treatment sessions every other day , over @number@ weeks on the periorbital areas.
STUDY DESIGN : This is a cross-sectional study.
STUDY DESIGN : This is a measurement study using cross-sectional and longitudinal data.
STUDY DESIGN : This is a retrospective pilot cohort study , conducted in a single university-affiliated hospital.
STUDY DESIGN : This study was a longitudinal assessment of variables drawn from an epidemiological prospective study of women's healthy ageing.
STUDY DESIGN : This was a prospective case-control study.
STUDY DESIGN : This was a prospective evaluation of @number@ postmenopausal women consecutively recruited from the database of three different investigators.
STUDY DESIGN : Ultrasound imaging of the brachial artery following reactive hyperaemia was conducted in @number@ children and @number@ adults.
STUDY DESIGN : Vertebral defects were created in a validated 3D finite element model ( FEM ) to simulate destructive tubercular lesions of increasing severity.
STUDY DESIGN : We collected placentas from women at 37-39 weeks ' gestation ( early-term and term ) , late-term , and with unexplained stillbirth.
STUDY DESIGN : We conducted a retrospective evaluation of donor oocyte recipient cycles according to specific ages.
STUDY DESIGN : We performed a population-based prospective cohort study among @number@ school-age children.
STUDY DESIGN : We retrospectively reviewed the charts of women with OAB who were evaluated between @number@ and @number@ in our urogynecology unit.
STUDY DESIGN : We used the CHS cohort data linked to participants Medicare claims.
STUDY ELIGIBILITY CRITERIA : Cross-sectional or prospective observational studies with data on TT and / or SHBG concentrations in combination with MetS in men.
STUDY ELIGIBILITY CRITERIA : Studies on the prevalence of self-medication in community-dwelling elderly were included.
Study endpoints were dementia , mild cognitive impairment ( MCI ) , or normal cognition.
Study exclusion criteria , ethical dilemmas , patient preference , risk of bias and challenges for treatment comparisons are particular problems faced by researchers.
Study finding reinforced the goodness of physical activity participation to enhance positive affect among the elderly.
Study findings have implications for developing interventions aimed at increasing and retaining functioning ability with the end goal of improving successful aging in this population.
Study findings indicated that older Black women experienced high levels of HIV stigma , retention in care , and ART adherence.
Study findings indicate that the main social support exchange for the elderly was with adult children living together , spouse , and friends / neighbors.
Study findings suggest a degree of plasticity associated with women's aging and , in particular , the age group correlated with perimenopause.
Study findings suggest that more mindful approaches to the transitions related to resident deaths would be valued by CNAs and could improve their work experience.
Study findings were mixed with both statistically significant and nonsignificant findings on various caregiver outcomes.
Study findings will increase awareness about the unique , complex needs of older women facing breast cancer with non-supportive intimate partners.
STUDY FUNDING / COMPETING INTEREST ( S ) : General Clinical Research Center for phlebotomy work has been supported in part by NIH grant UL1RR024986.
STUDY FUNDING / COMPETING INTERESTS : N.M.P.D. is supported by the Dutch Heart Foundation ( grant number 2013T083 ) .
STUDY FUNDING / COMPETING INTERESTS : No funding and no competing interests declared.
STUDY FUNDING / COMPETING INTERESTS : The FAC Clinic was established in @number@ as part of the ReproHigh collaboration.
STUDY FUNDING / COMPETING INTERESTS : This work was supported by grants from the National Natural Science Foundation of China ( NO.
Study implementation requires careful planning and monitoring to maintain fidelity to the scientific goals.
Study implications are further discussed , including specific suggestions for social programs and revisions to the physical environments.
Studying ethnically diverse groups is important for furthering our understanding of biological mechanisms of disease that may vary across human populations.
Studying in another cultural context can challenge these views.
Studying mitochondrial function in diseased cells vs healthy cells may reveal the modified mechanisms and molecular components involved in specific disease states.
Studying onabotulinumtoxinA in controlled settings is beneficial to treating a hyperfunctional orbicularis oris.
Studying the effects of medication in different age ranges appears useful to complete the studies on effects of medication.
Studying the role of FOXO in non-aging organisms might , therefore , illuminate the path to extend life span in aging organisms.
Studying this association will help in controlling the increase in spondylotic myelopathy with age.
Study limitations are not considered to impact on the study observations.
Study limitations include an open-label design and modest number of subjects.
Study limitations include reliance on self-reported PPI use and lack of dispensing data.
Study @number@ confirmed that user-centered design and the use of technology can be used to enhance daily living.
Study @number@ established convergent and discriminant validity with other measures of relationship quality , including an observational measure.
Study @number@ found associations with measures of positive relationship quality and high test-retest correlations using a sample of parents.
Study @number@ found high internal consistency and test-retest correlations among undergraduates.
STUDY : @number@ healthy female patients ( 40-70 years of age ) were treated with a picosecond pulsed alexandrite laser with a diffractive lens.
Study @number@ indicates that the test can be used with 2-year-olds , as it shows high test-retest reliability , demonstrating that 2-year-olds can think divergently.
Study @number@ led to Study @number@ demonstrating the need to conceptualize new ideas for smart nightstands.
Study @number@ manipulated participants ' future time perspective as a factor potentially contributing to age-related differences.
Study @number@ ( N = 449 ) extended these ratings to relationship-related memories and the phenomenological experience of the memory.
Study @number@ ( older adults only ) involved a low-cognitive demand session ( subtracting by 1s ) .
Study @number@ replicated this pattern with an adult life span sample including middle-aged individuals.
STUDY OBJECTIVE : Delirium is a common form of acute brain dysfunction with prognostic significance.
STUDY OBJECTIVES : Chronic non-healing wounds are a major human and economic burden.
Study Objectives : Cross-sectional studies suggest that insomnia symptoms are associated with falls in later life.
Study Objectives : Daytime sleepiness increases across adolescence.
Study Objectives : Determine the associations of sleep disturbances with hospitalization risk among older women.
STUDY OBJECTIVES : During normal sleep several neuroplasticity changes occur , some of which are considered to be fundamental to strengthen memories.
STUDY OBJECTIVES : During sleep deprivation ( SD ) , failures to respond ( FR ) increase across a variety of tasks.
STUDY OBJECTIVES : Growing evidence suggests that sleep disturbances precede by years the clinical onset of Alzheimer disease ( AD ) .
STUDY OBJECTIVES : Inflammation may represent a common physiological pathway linking both short and long sleep duration to mortality.
Study Objectives : In young adults , napping is hypothesized to benefit episodic memory retention ( eg , via consolidation ) .
STUDY OBJECTIVES : Light exposure , particularly blue light , is being recognized as a potent mean to stimulate alertness and cognition in young individuals.
Study Objectives : Menopausal transition is associated with increased dissatisfaction with sleep , but the effects on sleep architecture are conflicting.
STUDY OBJECTIVES : Narcolepsy is characterized by instability of sleep-wake , tonus , and rapid eye movement ( REM ) sleep regulation.
STUDY OBJECTIVES : Older adults and patients with dementia often have disrupted circadian activity rhythms ( CARs ) .
STUDY OBJECTIVES : Periodic limb movements in sleep ( PLMS ) are common in the elderly.
STUDY OBJECTIVES : Sleep deprivation and daytime somnolence impair numerous aspects of physical , cognitive , and memory performance.
STUDY OBJECTIVES : Slow wave EEG activity in NREM sleep decreases by more than @percent@ between ages @number@ and @number@ years.
STUDY OBJECTIVE : Steep Trendelenburg position is frequently used during gynecologic minimally invasive surgery ( MIS ) .
STUDY OBJECTIVES : The amplitude of the N550 component derived from the averaged evoked K-complex decreases with normal aging and with alcoholism.
STUDY OBJECTIVES : The impact of hospitalization on sleep in late-life is underexplored.
STUDY OBJECTIVES : The natural history of insomnia symptomatology is poorly understood.
STUDY OBJECTIVES : To determine how aging affects the impact of sleep deprivation on blood pressure at rest and under orthostatic challenge.
Study Objectives : To determine the association of actigraphic sleep duration and fragmentation with cognition in community-dwelling older women.
STUDY OBJECTIVES : To determine the combined effects of aging and propofol on autonomic nervous system activity using heart rate variability ( HRV ) analysis.
STUDY OBJECTIVES : To examine whether subjective sleep quality and sleep duration moderate the association between age and telomere length ( TL ) .
STUDY OBJECTIVES : To identify associations between sleep-disordered breathing ( SDB ) and arterial stiffness.
STUDY OBJECTIVE : The primary outcome was to measure physical health and emotional well-being.
STUDY OBJECTIVE : The trend in sleep duration in the United States population remains uncertain.
STUDY OBJECTIVE : To investigate the associations between sleep stage distributions and subsequent decline in cognitive function in older men over time.
STUDY OBJECTIVE : To investigate the facial cues by which one recognizes that someone is sleep deprived versus not sleep deprived.
Study of IL-2p showed reduced levels of expression in aged humans compared to young.
Study of the determinants of aortic stiffening process in this population may optimize cardiovascular prevention.
Study of the relationships between these factors may inform the development of interventions for depression in this service setting.
Study of verbal explicit memory impairment tapped by the NAL index may advance understanding of abnormal hippocampus dependent mechanisms common to schizophrenia and aging.
Study outcomes included the receipt of @number@ types of preventive screenings and @number@ types of health education services.
STUDY OUTCOME : Stroke incidence , subtypes and mortality will be calculated.
Study participants ages ranged from @number@ to @number@ with education ranging from @number@ to @number@ years.
STUDY PARTICIPANTS AND METHODS : Using a cross-sectional design , @number@ residents from @number@ Austrian nursing homes were recruited.
Study participants filled out a standardized questionnaire including report of their age at last menstrual period.
Study participants had baseline CSF biomarker measurements and longitudinal magnetic resonance imaging assessments for a mean follow-up period of @number@ to @number@ years.
Study participants included @number@ @number@ women aged 14-92 years , completing the menopause rating scale ( MRS II ) .
Study participants played all games three times with @number@ days in between sets.
Study participants received annual assessments of global cognitive function with the Modified Mini Mental State exam.
Study participants reported significant improvements in more physical activity and less emergency room ( ER ) visits and hospitalization during that period.
Study participants underwent two 3-week treatment periods-IF and IF with anti-oxidant ( vitamins C and E ) supplementation.
Study participants were followed in annual or biennial health examinations between @number@ and @number@
Study participants were n = @number@ hospital in-patients aged > 65.
Study participants were primarily minority and low income.
Study partners ( i.e. family members / friends ) were categorized as providing support with instrumental everyday activities or not.
Study personnel and patients remained blinded to the assigned treatments throughout the study.
Study platforms were activated using radio frequency ID cards providing electronic adherence monitoring ; placebo platforms resembled the active platforms.
Study population , resveratrol source , and dose have varied widely , potentially explaining inconsistent findings.
STUDY POPULATION : Seventy-five eyes from @number@ normal participants.
Study purpose was to determine whether arterial elasticity is related to strength , central and peripheral fatigue , fatigue at rest , and treadmill endurance.
Study quality ratings were low and , therefore , evidence was not strong enough to conclude that interventions were effective.
Study quality was adequate but variable.
Study quality was assessed using the Mixed Methods Appraisal Tool @number@
Study quality was independently assessed using an appraisal instrument.
Study quality was mixed.
Study quality will be assessed with the Effective Public Health Practice Project quality assessment tool.
STUDY QUESTION : Are differences in androgen levels among women with various forms of ovarian dysfunction associated with cardiometabolic abnormalities ?
STUDY QUESTION : Do advanced glycation end products ( AGEs ) and their receptors play a role in female reproduction ?
STUDY QUESTION : Does age of G-1 PLUS @date@ embryo culture medium affect IVF outcome ?
STUDY QUESTION : Is type @number@ diabetes a determinant of advanced ovarian ageing , resulting in an early age at natural menopause ?
Study respondents were geographically distributed throughout the United States , representing all @number@ states.
Study results underlined the contribution of participation in leisure activities both to the adaptation of an elderly person to his residence and to life satisfaction.
STUDY SAMPLE : A group of @number@ older adults ( mean age = @number@ years ) with normal hearing or minimal hearing loss participated.
STUDY SAMPLE : Articles were identified through systematic searches in the Web of Science , Medline , CINAHL , and a manual search.
STUDY SAMPLE : A sample of @number@ hearing aid user guides ( four user guides from nine different hearing aid manufacturers ) were analysed.
STUDY SAMPLE : A total number of @number@ people ( @number@ women , @number@ men ) were recruited from three age cohorts.
STUDY SAMPLE : A total of @number@ older adults were assessed ; @number@ participants had a hearing impairment and @number@ owned a hearing aid.
STUDY SAMPLE : A total of @number@ older adults were included.
STUDY SAMPLE : A total of @number@ subjects in the age range from @number@ to @number@ yr participated in this research.
STUDY SAMPLE : Audiological data of @number@ @number@ South African mine workers were investigated.
STUDY SAMPLE : Data was collected from @number@ otologically-normal persons aged between @number@ and @number@ years.
STUDY SAMPLE : Five hundred and seventy Mandarin speaking participants , aged from @number@ to @number@ years were included.
STUDY SAMPLE : Male twins born 1914-1958 , representing an unscreened population , were tested for hearing loss at two occasions , @number@ years apart.
STUDY SAMPLE : Nine CI users and nine NH listeners participated in this study.
STUDY SAMPLE : @number@ @number@ participants answered hearing questions.
STUDY SAMPLE : Participants were younger and middle-aged females ( n = @number@ per group ) with normal hearing through @number@ Hz bilaterally.
STUDY SAMPLE : Seven English-language Canadian newspapers were searched for publications between @number@ and @number@
STUDY SAMPLE : Ten young ( 21-35 years ) and @number@ middle-aged ( 48-57 years ) adults with normal hearing were included in the study.
STUDY SAMPLE : The participant sample included ten adults over the age of @number@ years who had owned hearing aids for at least one year.
STUDY SAMPLE : Thirty four adults ( aged 22-77 yr ) with hearing thresholds falling within normal limits.
STUDY SAMPLE : Three-hundred-and-seven individuals who were @number@ years or older and who presented with a unilateral or bilateral HI participated in the study.
Study sample was @number@ British civil service workers from the Whitehall II cohort.
STUDY SAMPLE : Young adults and middle-aged adults with normal hearing sensitivity participated in the experiment.
Study satisfaction was high.
STUDY SELECTION : All randomized double-blind placebo-controlled studies on @number@ ml / day of Cerebrolysin in mild-to-moderate AD were included.
STUDY SELECTION : A retrospective cohort study of @number@ liver transplant patients and @number@ control patients.
STUDY SELECTION : Articles studying the mitochondria-related pathologic mechanism and treatment of glaucoma were selected and reviewed.
STUDY SELECTION : Articles that specified both the methodology for quantifying melatonin and indicated the clinical purpose were chosen for inclusion in the review.
Study selection , data extraction , quality assessment , and data analyses were conducted according to Cochrane standards.
STUDY SELECTION : Eligible studies were published placebo-controlled double-blind RCTs published in English.
STUDY SELECTION : Forty-three eligible articles were identified , with @number@ selected for full review using a standardized critical review method.
STUDY SELECTION : Randomized and controlled clinical trials evaluating the effect of Pilates on balance and / or falls in older adults.
Study Selection : Randomized clinical trials ( RCTs ) of fall-prevention interventions for participants aged @number@ years and older.
STUDY SELECTION : RCTs and nRCTs comparing elderly before and after dance interventions with non-exercising controls and / or practitioners of other types of exercise.
STUDY SELECTION / SATA EXTRACTION : Articles were reviewed and selected considering relevance to the subject.
STUDY SELECTION : Search terms included community-based interventions , physical functioning , and cancer survivors.
STUDY SELECTION : Selected articles were original articles , clinical cases , review articles and meta-analysis.
STUDY SELECTION : Studies were included if they described an inpatient multidisciplinary approach to hip fracture management involving an orthopaedic surgeon and a geriatrician.
STUDY SELECTION : We identified @number@ studies evaluating disability outcomes in critically ill patients who were @number@ years and older.
Study settings included nine single hospital / dialysis centers and three regional / metropolitan areas and five were at the national level.
Study-specific associations of aPWV with CVD outcomes were determined using Cox proportional hazard models and random effect models to estimate pooled effects.
Study-specific risk estimates were pooled using a random-effects model.
Study subjects included @number@ healthy , elderly volunteers.
Study subjects reported no pain to moderate pain during treatment with no need of pain relief medication beyond topical anesthesia.
Study subjects were grouped into six 10-years age groups.
Study variability and methodological issues limit interpretation of available results.
Study variables included sociodemographic parameters such as age , sex , education , occupation , socioeconomic status , and marital status.
Study was conducted in multiple waves from 2003 / 2004 to @number@
Stunted and thin students had significantly fewer PT than their nonaffected peers.
Stunting is associated with adverse cognitive development in childhood and adolescence , fewer years of schooling , decreased productivity , and reduced adult stature.
STW focal sclerosis could explain focal degeneration of SE in senescence , although CN undergoes no significant changes.
SUA and MS were much more closely related in females than in males.
SUAbase was higher among men compared with that among women , and increased with GRStotal tertiles.
SU admission increased total score of @number@ ( @number@ % CI @number@.52-2.58 ) .
SUA was significantly positively related with body mass index and waist circumference.
Subanaesthetic ketamine is often administered intraoperatively for postoperative analgesia , and some evidence suggests that ketamine prevents delirium.
Sub-analyses suggested that the association between disturbed sleep and AL might be explained by underlying disorders.
Subanalyses were performed for autopsied subgroups with tauopathy ( n = @number@ ) and TDP-43 proteinopathy ( n = @number@ ) .
Sub-analysis was performed according to menopausal status.
Subcellular distribution of mTOR was investigated by immunofluorescent staining of RPE culture or flatmount.
Subcellular fractionation of the brain showed that the 1N isoform is over-represented in the soluble nuclear fraction.
Subclinical and clinical cardiovascular diseases accelerate the ageing process in part and in total.
Subclinical atherosclerosis was present in @percent@ of participants ( @percent@ of men , @percent@ of women ) .
Subclinical cerebrovascular disease was defined as silent brain infarcts and white matter hyperintensity volume ( WMHV ) .
Subclinical hypothyroidism is not necessarily a precursor to definite hypothyroidism.
Subclinical hypothyroidism ( SCH ) has a high global prevalence.
Subconjunctival fat prolapse is a rare clinical condition occurring typically spontaneously in elderly patients with a mean age of 65-72 years.
Subcortical hyperintensities ( SH ) are a commonly observed phenomenon on MRI of the aging brain ( Kertesz et al. , @number@ ) .
Sub-cortical reconstructions of the hippocampus and amygdala were generated using the longitudinal pipeline available with Freesurfer.
Subcutaneous adipose tissue in the areas corresponding to surface EMG electrode placements was measured via ultrasonography.
Subcutaneous adipose tissue was also lower in trained individuals but was not affected by age.
Subcutaneous filler injections enable to fill wrinkles and folds ; by using high density products it is also able to provide genuine facial volumetric reconstruction.
Subcutaneous injection of ADSC significantly increased collagen synthesis in hairless mice , and dermal thickness , collagen density and fibroblast number also increased.
Subcutaneous preadipocytes treated with interleukin-6 ( IL-6 ) resembled omental preadipocytes in terms of chemokine secretion and macrophage / monocyte chemoattraction.
Subdental and neurocentral synchondroses closed simultaneously after @number@ years ( range 7-9.5 years ) .
Sub-domains of MOCA responsible for the relationship were predominantly memory recall and language.
Subdural hematoma evacuation was associated with decreased mortality but did not significantly protect against poor discharge disposition and was associated with significantly higher cost.
Sub-epidermal separations and altered orientation of collagen fibers were observed in aged skin at earlier time points.
Subfertility relates with reproductive aging ( RA ) .
Subgroup analyses by cancer site and stage and by beta-blocker type were conducted.
Subgroup analyses by sex and age group yielded similar results.
Subgroup analyses found unhealthy weight gain occurred regardless of patients ' receipt of cranial radiation therapy , sex , and , weight status at diagnosis.
Subgroup analyses indicated that various methodological and clinical factors can influence the study results.
Subgroup analyses raised concerns about an increase in infarct size among older patients.
Subgroup analyses revealed that studies with ( predominantly ) men showed similar SMF responses between the older and the young groups.
Subgroup analyses showed decreased risk in Chinese , HBV- and HCV-related HCC.
Subgroup analyses were conducted by age group , history of HF hospitalization , and type of universal health security program enrolled in.
Subgroup analyses were conducted by sex and race / ethnicity.
Subgroup analyses were done for menopause status , smoking habits and histology.
Subgroup analyses were performed to identify sources of heterogeneity.
Subgroup analysis also did not reveal serotype-dependent differences in survival , nor a relationship between survival and human plasma viremia levels.
Subgroup analysis identified greater effectiveness of person-centered care when implemented for people with less severe dementia.
Subgroup analysis was also performed for each risk-factor category.
Subgroup analysis was performed according to the age between the two groups.
Subgroup analysis was performed based on offspring education level.
Subgroup analysis was performed comparing 10years ' intervals from ( 30-40 ) and from ( 40-50 ) .
Subgroup and meta-regression analyses were used to study the influence of age and potential moderating factors.
Subgroup variations included the likelihood of discussing health-related issues with network members.
Subiculum volumes were more negatively related to age in men than in women.
Subject and investigator satisfaction was evaluated using the Global Aesthetic Improvement Scale.
Subject and investigator satisfaction was high , and the procedure was well tolerated.
SUBJECT AND METHODS : The study was conducted in the municipality of Tuzla in 2009-2010 , in outpatient family medicine Simin Han.
Subject-based reports of motivation , fun , pain , and fatigue evaluated on 0-to-10 numeric rating scales were compared between groups.
Subject biological age but not chronological age correlated with a decrease in stool microbial diversity.
Subject characteristics were calculated by CAG status and SI.
Subject degree of satisfaction and self-assessed rate of response were also measured.
Subject group consisted of @percent@ of people living alone , and @percent@ control group consisted of elderly patients who live in traditional family surroundings.
Subjective age , or how young or old individuals experience themselves to be relative to their chronological age , is a crucial construct in gerontology.
Subjective age was operationalized as felt age relative to chronological age.
Subjective aging has a small significant effect on health , health behaviors , and survival.
Subjective and objective measures of physical function were compared between the two groups , accounting for potential confounders.
Subjective and objective ( oral ) health measures showed differences between Germany and Poland.
Subjective appetite was measured at regular time points for 60min after meal initiation.
Subjective assessments by investigator and participants were performed @number@ month after each treatment.
Subjective benefit could not be predicted by any of the variables considered.
Subjective burden was assessed with the Carers ' Assessment of Difficulties Index ( CADI ) .
Subjective caregiver burden explained the greatest amount of total variance in all MH subscales and the 2nd greatest amount of variance in most physical subscales.
Subjective closeness and frequency of contact with extended family and friends and negative family interaction were examined in relation to lifetime suicide ideation and attempts.
Subjective closeness to friends and negative family interaction were positively associated with suicide ideation and attempts.
Subjective cognitive complaint was examined using the Memory Complaint Questionnaire ( MAC-Q ; score 0-30 , best ) .
Subjective cognitive difficulties were scored on the McNair and Kahn Scale.
Subjective cognitive impairment ( SCI ) is a clinical state characterized by subjective cognitive deficits without cognitive impairment.
Subjective current health status and employment status influenced the life span trajectory of nonfamily social contact only.
Subjective estimates of listening effort did not correlate with any of the objective dual-task measures.
Subjective fatigue at rest was related to large artery elasticity after adjusting for ethnic origin ( < 0.02 ) .
Subjective Global Assessment performed by site coordinators was used as a gold standard for comparison.
Subjective global assessment ( SGA ) and weight measurements were performed at admission and discharge.
Subjective improvements of cognitive functions due to the training were reported.
Subjective improvement was assessed by patient questionnaires.
Subjective knowledge was found to be a stronger predictor of fish consumption than the previously noted factors.
Subjective life expectancy is a powerful predictor of a variety of health and economic behaviors.
Subjective memory complaints are often used as diagnostic criteria for several neurocognitive disorders.
Subjective memory complaints are very common among elderly.
Subjective memory concerns are common in older adults and may prompt the use of web-based cognitive screening.
Subjective memory impairment ( SMI ) is considered the earliest clinical stage of Alzheimer's disease ( AD ) .
Subjective norm was mostly associated with the SOC followed by attitude and perceived control.
Subjective organization was measured by using the Paired Frequency measure.
Subjective push-up amplitudes were the dioptric distance at which the target first blurred along a near-point rod.
Subjective ratings of recalled memories were largely comparable between the groups.
Subjective reports of symptoms are typically obtained in clinical settings , yet the validity of these reports is relatively unknown.
Subjective reports regarding perceived decline in olfactory detection and olfactory identification were also obtained.
Subjective sleep complaints were evaluated according to the St. Mary's Hospital Sleep Questionnaire and the Epworth Sleepiness Scale score.
Subjective sleepiness measured with the KSS increased with shorter sleep duration , but this effect did not change with age.
Subjective socioeconomic status during childhood and current height were obtained by self-report through questionnaire in @number@
Subjective stress , mood , and state self-esteem assessments were made before and after stress.
Subjective symptoms including nasal dryness , burning , obstruction , itching and crusting were evaluated by a visual analog scale.
Subjective wellbeing and health are closely linked to age.
Subjective well-being is measured by happiness and life satisfaction , and leisure participation is examined by the type and diversity of leisure activities.
SUBJECT / METHODS : A total of @number@ middle-aged and older Korean adults from a population-based cohort were included in the study.
Subject perception of the efficacy , tolerance and cosmeticity of the tested products were assessed at days @number@ @number@ and @number@
Subject questionnaires showed the test product was highly rated.
Subject-reported assessments of treatment efficacy were evaluated using a questionnaire administered at week @number@
Subject-reported satisfaction was high , as indicated by the self-assessment on the GAIS and results from the subject satisfaction questionnaire.
Subjects ( 20-89 years ) were stratified by age into seven groups.
SUBJECTS : About @number@ aged @number@ and older community residents in Beijing metropolitan area , China.
SUBJECTS : Adults aged 30-64 years ( n @number@ ) who participated in the Healthy Aging in Neighborhoods of Diversity across the Life Span study.
SUBJECTS : Adults aged 60-71 years.
SUBJECTS : African American and white adults ages @number@ to @number@ years residing in @number@ predefined census tracts in Baltimore , Maryland.
SUBJECTS : African-American and White adults with two dietary recalls ( n @number@ ) .
Subjects aged @number@ @number@ and @number@ years scored ≤2 , while the two oldest age groups had scores ≤3.
Subjects aged @number@ to @number@ years who have full National Health Insurance coverage in @number@ were included.
Subjects aged @number@ years and older were included in the present study.
Subjects also completed an electrophysiologic gap detection procedure to determine their electrophysiologic gap detection threshold ( EGDT ) .
Subjects also completed @number@ trials of an explosive push-up ( EPU ) on a force plate over @number@ testing days.
Subjects also performed a control exercise recovery ( CER ) test to compare data from the PEMI test.
Subjects also performed a spatial- or non-spatial-memory cognitive task during the delay-time in a subset of trials.
Subjects also rated the tolerability of the treatments.
Subjects also received deep subdermal injection of CaHA ( ~0.1 ml ) of the same dilution in the peri-auricular area for skin biopsy.
Subjects also reported the frequency of dermatologic facial product use.
SUBJECTS : Analysis based on @number@ children whose parents participated in the survey and provided measured heights and weights.
SUBJECTS AND METHODS : A total of @number@ ambulatory subjects ( age 51-95 years , median @number@ @number@ female ) were studied.
SUBJECTS AND METHODS : A total of @number@ participants were randomly selected at a megamall in Jeddah , on @date@ .
SUBJECTS AND METHODS : A total of @number@ patients older than @number@ years were studied.
SUBJECTS AND METHODS : A total of @number@ postmenopausal women were included in this cross-sectional study , which was conducted during their medical check-ups.
SUBJECTS AND METHODS : Eighty-three high school students were enrolled in the study.
SUBJECTS AND METHODS : Fifty-two healthy subjects were divided into five groups by age.
SUBJECTS AND METHODS : Five hundred and sixty one healthy adults aged between @number@ to @number@ years volunteered for this study.
SUBJECTS AND METHODS : In total , @number@ parameters of breast were measured with participants in a standing position.
SUBJECTS AND METHODS : Life-quality linked to health was measured with an SF-36 survey , which gives multi-dimensional criteria of health and life-quality.
SUBJECTS AND METHODS : Mean arterial pressure and SDPTG before and after meal ingestion in young and elderly subjects were measured.
SUBJECTS AND METHODS : @number@ elderly demented patients underwent clinical , bio-chemical and functional assessment.
SUBJECTS AND METHODS : Patients were randomly subdivided into two groups.
SUBJECTS AND METHODS : Patients with a diagnosis of heart failure were recruited from a variety of community settings.
Subjects and Methods Patients with UVFP onset > 6 months were recruited ( N = @number@ ) .
SUBJECTS AND METHODS : Subjects tested were healthy volunteers and patients who visited Dental Clinical Division of Hokkaido University Hospital.
SUBJECTS AND METHODS : Subjects were Medicare beneficiaries.
SUBJECTS AND METHODS : The model was formulated as a discrete Markov process.
SUBJECTS AND METHODS : The sample consisted of @number@ cognitively healthy controls and @number@ patients with Alzheimer's disease.
SUBJECTS AND METHODS : The sample consisted of @number@ elderly persons aged between @number@ and @number@ years.
SUBJECTS AND METHODS : The sample consisted of sixty-four healthy young adults ( @number@ females and @number@ males , mean age @number@ years ) .
SUBJECTS AND METHODS : The subjects were @number@ institutionalized older adults ( aged @number@.2±6.5 years ) .
SUBJECTS AND METHODS : This was a cross-sectional study including medical outpatients from a Social Security Hospital in Southeast Mexico.
SUBJECTS AND METHOD : Ten Korean women were enrolled in this study.
Subjects and physicians assessed treatment outcomes using the 5-point Global Aesthetic Improvement Scale ( GAIS ) .
SUBJECTS AND SETTING : Potential participants were randomly selected from an electronic database of @number@ persons with ostomies.
Subjects applied EGF serum to the infraorbital area twice daily for @number@ weeks.
Subjects are classified by age ( old > 35 years and young ˂35 years ) and by meiotic error ( MI and MII ) .
Subjects are placed in the supine position and allowed to rest quietly for at least @number@ min prior to the start of the exam.
Subjects assessed pain on a 100-mm visual analog scale ( VAS ) .
Subject satisfaction and comfort was evaluated using self-administered questionnaires at day @number@ and at week @number@
Subject satisfaction ( @percent@ ) , subject recommendation of the treatment ( @percent@ ) , and investigators GAIS scores ( @percent@ improvement ) were high.
Subject satisfaction scores were @number@ ( range @date@ @number@ ) at @number@ weeks and @number@ ( range @date@ @number@ ) at @number@ weeks.
Subject Satisfaction scores were significantly different ( p < @number@ ) between treatment groups beginning week @number@ and continuing through month @number@
Subject satisfaction , treatment tolerability , and subject outcome assessment were performed.
Subject satisfaction was high.
Subject satisfaction with appearance was also analyzed.
SUBJECTS : a total of @number@ community-dwelling individuals aged ≥68 years in Spain.
SUBJECTS : A total of @number@ elderly aged @number@ years and over ( mean @number@.9±5.6 years ) participated in this study.
SUBJECTS : A total of @number@ first-born children ( @percent@ male ) .
SUBJECTS : A total of @number@ French community dwellers aged @number@ years old and over from the PAQUID study were included.
SUBJECTS : a total of @number@ individuals aged 50-75 years.
Subjects : a total of , @number@ patients diagnosed with AD registered 2011-14 in SveDem , the Swedish Dementia Registry.
Subjects ' audiograms were analyzed for air conduction thresholds with age correction performed in accordance with ISO @number@
Subjects began each trial by holding the hand within the central target for @number@ milliseconds.
Subjects began stepping over the force platform in response to an auditory stimulus.
Subjects characterized by a general lifestyle showed higher everyday competence than those with a sedentary lifestyle or subjects who needed care.
SUBJECTS : Chinese older adults ( n @number@ ) aged @number@ years and above in the Singapore Longitudinal Ageing Studies.
Subjects completed a graded exercise test to determine maximal oxygen uptake ( VO2peak ) and muscle biopsies were obtained from the vastus lateralis.
Subjects completed a questionnaire at both @number@ weeks and @number@ months after treatment.
Subjects completed @number@ trials and the last @number@ were used for analysis.
Subjects completed tasks assessing executive functioning , episodic memory , speed , and general knowledge.
Subjects comprised a homogeneous population of American men of Japanese ancestry , well characterized for aging phenotypes and who have been followed for @number@ years.
Subjects comprised @number@ PD cases and @number@ controls.
Subjects considered had best corrected visual acuity by standardized subjective refraction of 20 / 40 or better.
SUBJECTS : Current drinkers 60years and older accessing primary care clinics around Santa Barbara , California ( N = 1049 ) .
SUBJECTS : Data were analyzed from @number@ community-dwelling CDSMP participants.
SUBJECTS : Eight healthy postmenopausal women , 48-74 yr old , without sleep complaints or vasomotor symptoms.
Subject self-assessment , however , showed a significant and growing preference toward the investigated JM product over the course of the study.
Subject self-evaluations showed that both treatments were effective , with a nominal preference for combination treatment.
Subjects eligible were diagnosed with biopsy-verified prostate cancer , naïve.
Subjects exercised according to the Bruce protocol , to achieve @number@ % of their age-predicted maximum heart rate or until the appearance of exercise-associated symptoms.
Subjects expended @number@ ± @number@ kcal / session ( @number@ ± @number@ kcal / wk ) during the intervention and lost ~8% body weight.
Subjects exposed to the placebo did not show any significant difference in BP or HR between pre-injection and postinjection.
SUBJECTS : Fifty two elderly patients ( @number@ male , @number@ female ) with anemia , 65-91 years of age.
SUBJECTS : Forty-six depressed females , aged 66-95 years.
Subjects for whom the Cmax fell within the sampling period ( over 2h ) , Cmax was @number@.42-4.57ng / mL and Tmax was 67-92min.
SUBJECTS : four hundred and sixty patients @number@ years or older admitted between @date@ and @date@ .
Subjects from both studies underwent similar clinical and neuropsychological assessments and brain magnetic resonance imaging.
Subjects from the general population ( n = @number@ males @number@ @percent@ White , @percent@ Black , and @percent@ others ) were studied.
Subjects from the METASTROKE consortium served as a replication sample.
Subjects from YDH group also showed lower iNOS expression , compared with all other groups.
Subjects had a mean age of @number@ years.
Subjects had at least @number@ headaches per month , and no limit was placed on the number of headaches per month that could be experienced.
Subjects had at least two indications for BoNT-A treatments on each third of the face ( upper , middle and lower ) .
Subjects had undergone a magnetic resonance imaging ( MRI ) scan and APOE genotyping.
SUBJECTS : hundred and one inpatients on a rehabilitation ward , @number@ community rehabilitation referrals and @number@ nursing home residents.
Subjects identified the order of two 1-ms clicks presented monaurally in rapid succession.
Subjects ' improvement assessment and subjective self-satisfaction levels were also investigated.
Subjects included @number@ community residing older adults with dementia who participated in @number@ of @number@ interventions being tested in randomized clinical trials.
Subjects included @number@ controls , @number@ mild cognitive impairment ( MCI ) , and @number@ AD subjects with serial volumetric @number@.5-T MRI.
Subjects included @number@ obese but otherwise healthy adult women.
Subjects included @number@ obese children ( 12·5 ± 2·9 years ) .
Subjects included premanifest ( tested ) and at-risk ( not tested ) individuals without clinical symptoms or signs of Huntington disease ( HD ) .
Subjects in Cohort @number@ were treated with the highest dose and observed for @number@ weeks or until GLSS returned to baseline.
Subjects indicated that information regarding medication regimens and adherence , calendaring , and cognitive health were most needed.
Subjects indicated whether each test item was recollected , familiar , or novel.
Subjects in the group II received one intravaginal estriol ovule ( @number@ mg ) plus pelvic floor rehabilitation in a similar regimen.
Subjects in their early 40s showed the best improvement in comparison to younger and older age groups.
Subjects in the non-implementation group had worse functional status , their somatic comorbidity was more severe , and their clinical condition more unstable.
Subjects in the NRP-e group also received weekly email alerts and phone calls from a nurse care manager for @number@ months.
Subjects in the top quintile of the combined GRS had > 2-fold increased risk of IS compared with subjects in the lowest quintile.
Subjects learned associations between nine equi-familiar common objects and locations in a nine-location grid.
Subject's level of comfort was measured with Kolcaba's verbal rating scale ( VRS ) .
Subjects made brisk walking twice a day during the whole follow-up including both CR and IF periods.
SUBJECTS / MATERIALS AND METHODS : The authors analyzed data from @number@ consecutive patients admitted in @number@
SUBJECTS : Men and women aged 50-69 years at baseline ( n @number@ ) and at 10-year follow-up ( n @number@ ) .
SUBJECTS / METHODS : Adult patients were admitted to surgical and medical wards only ( no palliative patients ) .
SUBJECTS / METHODS : A total of @number@ community-dwelling men and women aged 65-87 years were randomly assigned to two groups.
SUBJECTS / METHODS : Serum 25 ( OH ) D was measured in three Danish population-based studies , including @number@ adults aged 18-64 years.
SUBJECTS / METHODS : This is a multicenter study on a population-based sample of Italian people aged 65-84 years.
SUBJECTS / METHODS : This was a 5-year observational , longitudinal study on the menopausal transition.
SUBJECTS : nine hundred and twenty-three community-dwelling individuals aged @number@ and older.
SUBJECTS : @number@ adults aged ≥50 years from The Irish Longitudinal study on Ageing.
SUBJECTS : @number@ community dwelling older adults , aged 55-85 years.
SUBJECTS : @number@ community-dwelling older subjects aged > or = 60 assessed between @date@ and @date@ ( mean age @number@ SD @number@ ) .
SUBJECTS : @number@ males and females aged ≥60 years over 15-year of follow-up.
SUBJECTS : @number@ participants ( @percent@ men and @percent@ women ) , the average of age for both genders was @number@ ± @number@
SUBJECTS : Nurses and physicians who had experience working the night shift.
SUBJECTS : Nursing home residents and healthcare agents of incapacitated nursing home residents ( n = @number@ ) .
SUBJECTS : Older adults ( n @number@ ) who were independent in ADL in @number@
SUBJECTS : older people admitted as emergencies.
SUBJECTS : older people aged @number@ years and over.
Subjects older than @number@ years had a significantly worse ADL score ( P < 0.05 and P < 0.001 ) .
SUBJECTS : one hundred and fifteen free-living non-sarcopenic older men and women aged 60-84 years at baseline and 5-year follow-up were included.
SUBJECTS : one hundred and fifty patients with surgical fixation for a hip fracture.
SUBJECTS : One thousand five hundred thirty adult patients who required renal replacement therapy initiation in the ICU.
Subjects over the age of sixty comprised @percent@ with only @percent@ being under the age of forty five.
SUBJECTS : Overweight and obese subjects ( n = 1225 ) were evaluated at baseline in five weight loss clinics in southeastern Spain.
SUBJECTS : Participants were @number@ people aged @number@ and older , prospectively recruited from a U.S. hospital following CAB surgery.
Subjects participated in their respective interventions twice a week for @number@ weeks.
Subjects participated in the three campaigns in random order.
SUBJECTS : Patients aged ≥70 years , electively or acutely hospitalised for ≥2 days.
SUBJECTS : Patients with type @number@ diabetes aged @number@ years or older.
Subject-specific random intercept for BMI was the predictor for ADNP due to minimal BMI change ( p = @number@ ) .
SUBJECTS : people aged @number@ or older registered continuously with a general practitioner in five selected areas of England ( n = @number@ ) .
Subjects performed a @number@ × 10RM leg press exercise protocol before and after @number@ weeks of hypertrophic resistance training.
Subjects performed a self-evaluation at the end of the study.
Subjects performed a step with self-selected step length onto the force plate to establish a single leg stance ( SLS ) on their dominant leg.
Subjects performed a texture discrimination task in the peripheral visual field and a letter discrimination task in central vision.
Subjects performed IAA tasks with and without a deep and constant breathing pattern in two sessions.
SUBJECTS : population based sample of @number@ participants aged @number@ years.
Subjects ranged in age from @number@ to @number@ years.
Subjects rated improvements in GL severity and completed the Facial Line Outcomes ( FLO ) and Self-Perception of Age ( SPA ) questionnaires.
Subjects received an i.v. infusion of @number@ mg / kg dipyridamole.
Subjects received financial , instrumental , and emotional support , and they actively provided instrumental and emotional support to others.
Subjects received @number@ bi-weekly laser treatments.
Subjects received @number@ ± @number@ stimulation bouts during surgery.
Subjects received Princess VOLUME in both nasolabial folds at Day @number@
Subjects received three split-face treatments @number@ weeks apart.
Subjects receiving one session of treatment and evaluations were conducted at baseline , four weeks , and twelve weeks after treatment.
Subjects remained on treatment throughout the 3-month study.
Subjects reported fluid intake , while urine output was measured and sweat rate was calculated.
Subjects reported high levels of satisfaction.
Subjects reported no treatment-related adverse events after the second retreatment.
Subjects reported post-treatment improvements in other characteristics associated with healthy skin.
Subjects reported satisfaction with treatment in > 90% of their onabotulinumtoxinA visits and in @percent@ of their incobotulinumtoxinA visits.
Subjects reported that , at Day @number@ @percent@ of the maximal effect ( defined as the effect on Day @number@ ) persisted.
Subjects returning for their month-2 visit were offered open-label quinacrine.
Subjects scored @number@ or greater on the Mini-Mental Status Exam and completed mental health assessments.
Subjects scoring higher than @number@ on the BI and higher than @number@ on the MEC were compared with the rest.
Subjects ' self-efficacy was also assessed using the activities-specific balance confidence ( ABC ) scale.
Subjects ' sex and age had no effects on these relationships.
Subjects spent @number@ minutes in a quiet standing ( QS ) position.
SUBJECTS : Studies involved samples of people of all ages.
SUBJECTS : Subjects included healthy PMW , 45-55 ( n = @number@ ) and 70-80 ( n = @number@ ) years old.
SUBJECTS : The subjects included @number@ @number@ and @number@ community-dwelling adults aged @number@ years and above in @number@ @number@ and @number@
SUBJECTS : The subjects under consideration are both MOW clients and volunteers.
SUBJECTS : thirty-six young adults ( 18-33 years ) and @number@ healthy older adults ( 63-85 years ) .
SUBJECTS : Three thousand two hundred and sixty community-dwelling individuals , @number@ years and older.
Subjects treated for CFL and GL experienced even greater effects.
Subjects underwent both brain MRI and comprehensive neurocognitive assessment.
Subjects underwent magnetic resonance imaging ( MRI ) .
Subjects underwent neuropsychological assessment , fasting blood draw and brain magnetic resonance imaging ( MRI ) .
Subjects underwent pre- and post-treatment ( @number@ days ) ultrasound scans to determine dermal thickness around the umbilicus and sides of the abdomen.
Subjects underwent right heart catheterization to define LV pressure-volume curves ; secondary functional outcomes included cardiopulmonary exercise testing and arterial compliance.
Subjects underwent standardized history and examination , including demographics and assessment of pelvic floor function and sexual function using validated quality-of-life instruments.
Subjects used a 0-10 grading scale for self-assessment of photoaging.
Subjects used the study serum product containing @percent@ salicin on their face twice daily for @number@ weeks.
Subjects wearing cosmetic make-up appeared @number@ years younger than those wearing no make-up.
SUBJECTS : We followed @number@ middle-aged and older adults , totalling @number@ person-years.
Subjects - we included @number@ subjects from the Italian Brain Normative Archive database.
Subjects were also divided into hyperuricemia and normal SUA groups.
Subjects were also genotyped for the BstUI RFLP ( C / T ) within the @number@'-untranslated region of the COL5A1 gene.
Subjects were asked to complete a postal questionnaire , which enquired about lifestyle and the occurrence of musculoskeletal pain over the past month.
Subjects were asked to use the highest device setting.
Subjects were asked to walk @number@ m at their own self-selected speed.
Subjects were asked whether they had ever had an HT with loss of consciousness.
Subjects were assessed using the Geriatric Mental State Examination , the Mini-Mental State Examination and Short Form @number@ and their prison records.
Subjects were assigned to groups based on their stepping strategy.
Subjects were categorized for time in service and flying hours.
Subjects were categorized into CRF categories ( high , moderate , and low ) relative to age and gender normative classifications.
Subjects were categorized into individuals with MetS and individuals without MetS.
Subjects were categorized into normal cognitive function , mild cognitive deterioration , and moderate-to-severe cognitive impairment and were further stratified by physical disability status.
Subjects were characterized using the Clinical Dementia Rating ( CDR ) as either nondemented or with very mild to mild Alzheimer's disease.
Subjects were classified as Aβ42 + ( < 550 pg / mL ) or Aβ42- ( > 550 pg / mL ) .
Subjects were classified as having NHAP ( Group A ) or other pulmonary disorders ( Group B ) .
Subjects were classified as \ "regular \ " or \ "nonregular \ " exercisers on the basis of participation frequency and adherence.
Subjects were classified at baseline according to their number of risk factors ( from @number@ to @number@ and more ) .
Subjects were divided into equal groups based on age and gender.
Subjects were divided into low- and high-fitness groups within each age group according to the median VO2peak value.
Subjects were divided into @number@ groups according to age ( 41-59 , 60-69 and ≥ @number@ years ) and further into HT and non-HT sub-groups.
Subjects were divided into @number@ groups according to SPMSQ score ( either impaired < @date@ or normal ≥ @date@ ) .
Subjects were divided into @number@ groups based on a 2-GROUP ( young or old ) by 2-ORDER ( random or blocked practice ) between-subject design.
Subjects were divided into seven age-groups.
Subjects were divided into six cross-sectional age groups.
Subjects were divided into tertiles of CAS score for analysis.
Subjects were divided into those with COPD and controls.
Subjects were divided into three groups according to age at PHV ( early , middle , and late ) .
Subjects were divided into three groups , normal , osteopenia , and osteoporosis , depending on their young adult mean BMD % value.
Subjects were divided into two groups based on the relative direction of ghrelin response to a standard meal.
Subjects were drawn from nonclinical populations.
Subjects were eligible if the investigator had already decided to prescribe BoNT-A ( s.U ) , according to the labelling.
Subjects were enrolled in a multicenter chemoprevention trial of aspirin or folic acid for the prevention of large bowel adenomas.
Subjects were examined with a neurological test battery to identify symptoms of FXTAS and a neuropsychological test battery to investigate cognitive and behavioral profiles.
Subjects were experiencing , on average , mild levels of depression and minimal manic symptoms.
Subjects were followed for @number@ year.
Subjects were followed for up to @number@ months after their initial treatment.
Subjects were followed periodically for @number@ years , and progression to dementia was evaluated.
Subjects were followed up at @number@ and @number@ months post last treatment.
Subjects were followed-up over @number@ years for the detection of dementia.
Subjects were followed up to week @number@
Subjects were free of manifest cardiovascular disease , cardiovascular risk factors , and significant coronary artery disease as determined by electron-beam computed tomography.
Subjects were grouped as follows : 0-3 , 4-12 , 13-24 months , 2-5 , 6-10 , and 11-16 yr.
Subjects were grouped based on a hypothetical construct correlating pathological features with PADW stages.
Subjects were grouped by very low calcium score ≤10 and scores above @number@
Subjects were identified from a trauma registry kept in our Department and were tested for eligibility.
Subjects were instructed to abduct their leg as forcefully and quickly as possible under isometric condition , in response to audible beeps.
Subjects were instructed to apply HA5 LS at least three times a day to ensure coverage @number@ hours a day for four weeks.
Subjects were instructed to maintain gaze on target during quiet stance with or without yaw surface rotations.
Subjects were instructed to \ "perform the lateral step and keep walking forward \ ".
Subjects were matched with respect to age , body mass index , ethnicity , sex , and smoking status.
Subjects were @number@ community-dwelling Japanese men and menopaused women , aged 40-81 years.
Subjects were @number@ healthy family members of early-onset coronary artery disease patients.
Subjects were @number@ healthy women aged > 60.
Subjects were @number@ pre-menopausal women.
Subjects were @number@ professional music therapists from all seven American Music Therapy Association ( AMTA ) regions with an overall average longevity of @number@ years.
Subjects were @number@ white postmenopausal women age @number@ to @number@ years in good general health.
Subjects were otherwise much more likely to grasp the rail in reaction to the perturbation.
Subjects were part of the general population or clinic-referred cohort of the TRacking Adolescents ' Individual Lives Survey ( n = @number@ ) .
Subjects were @percent@ women , @percent@ African-American , mean age @number@ ± @number@ years.
Subjects were randomized to daily transdermal @percent@ T gel plus oral placebo or dutasteride for @number@ months.
Subjects were randomized to receive an injection of Emervel Classic or Restylane on their left or right side.
Subjects were randomized to receive injection of HA ( E ) or HA ( P ) on their left or right NLF.
Subjects were randomly assigned to either an experimental group ( n = @number@ ) or a control group ( n = @number@ ) .
Subjects were receptive to the skills and the delivery methods.
Subjects were sampled based on a diagnosis of a chronic medical illness with chronic pain as one of the major symptoms.
Subjects were separated into @number@ groups based on the number of falls : @number@ @number@ @number@ and ≥ @number@ falls.
Subjects were separated into @number@ groups based on the number of falls : @number@ @number@ @number@ and ≥ @number@ falls.
Subjects were stratified according to whether a uterine manipulator was used during surgery ; if so , the type of manipulator was identified.
Subjects were switched to incobotulinumtoxinA at unit doses that were numerically and statistically similar to the onabotulinumtoxinA doses they received in period @number@
Subjects were tasked with judging objects in this second viewing as having retained their original location , or having moved.
Subjects were then followed during outpatient visits and hospitalization.
Subjects were then followed for @number@ years to identify those who developed MCI.
Subjects were trained to criteria to equalize initial learning across subjects.
Subjects were treated with a new non-ablative fractional Q-Switched @number@ , 064-nm Nd : YAG laser ( Harmony XL , Alma Lasers Ltd. ) .
Subjects were treated with either ashwagandha-root extract ( @number@ mg twice daily ) or placebo for eight weeks.
SUBJECTS : we used data from @number@ NH residents , and @number@ H patients.
SUBJECTS : White and African-American US adults ( n @number@ ) , aged 30-64 years.
Subjects who failed this initial screen were tested with secondary screening tests.
Subjects who failed to respond because of subjective measures tended to have higher DAS28-P scores at baseline.
Subjects who improved in nutritional status had a significantly higher MEMS score at discharge ( p < 0.001 ) .
Subjects who suffered from severe pain and were more fearful of falling were most likely to be severely osteoporotic.
Subjects who thought tanned skin was important were significantly more likely to report interest in improving their appearance through cosmetic procedures and medical means.
Subjects with a FRAX® value lower than the NOF thresholds were not considered at high risk.
Subjects with a lower limb fracture in the follow-up were excluded.
Subjects with aMCI were older at death ( @number@ vs. @number@ years of age , p = @number@ ) .
Subjects with an improvement of at least @number@ point on the FWS were considered responders.
Subjects with a recurrent depression had higher plasma NGAL levels compared to those with a first episode.
Subjects with a score ≥90% of the distribution in the total sample were classified having LSC.
Subjects with at least @number@ migraine headaches in this period were then entered into Period B and randomized into either amitriptyline or placebo tracks.
Subjects with baseline radiographic hip osteoarthritis were excluded.
Subjects with clinical or DAT PET evidence of Parkinson disease ( PD ) were not eligible for the study.
Subjects with cognitive impairment had lower family functioning scores than those without cognitive impairment ( P = @number@ ) .
Subjects with coincident MTL showed lower hippocampal volume.
Subjects with common variable immune deficiency may have mutations in transmembrane activator calcium modulator and cyclophilin ligand interactor ( TACI ) .
Subjects with DS can develop some traits of Alzheimer disease ( AD ) at an earlier age than subjects without trisomy @number@
Subjects with evidence of structural heart disease or arrhythmias were excluded.
Subjects with fear of falling had a median FES score of @number@ ( interquartile range , @number@ to @number@ ) .
Subjects with fragile X syndrome and their unaffected siblings were recruited and their parents filled out functional-behavioral and psychiatric comorbidities questionnaires.
Subjects with full fan at maximum smile were most dissatisfied with their appearance and perceived themselves to look older versus other patterns.
Subjects with glaucoma and corneal or retinal diseases were excluded.
Subjects with higher education levels were seen to be more likely to be resilient to the deleterious effects of severe WML.
Subjects with higher p-tau ( @number@ ) and p-tau ( @number@ ) / Aβ42 had less GM in temporal lobes.
Subjects with hypertension showed more GM atrophy in the cerebellum , occipital , and frontal regions.
Subjects with incident AF had a @number@.5-fold risk of death in comparison with those without AF.
Subjects with incident CKD had a @number@.792-fold higher risk of developing new CKD complications.
Subjects with incident nonspine fractures were older , had lower total hip bone mineral density ( BMD ) , and higher serum phosphorus.
Subjects with known history of metabolic or endocrine diseases , sports or traumatic injuries , peripheral vascular disorders were excluded.
Subjects with LDD had an increased OP fracture risk compared to subjects without LDD ( HR : @number@ CI : @number@ @date@ ) .
Subjects with LTCF-acquired infections were more likely to die than those without infections.
Subjects with normal BMI with elevated body fat may metabolically have higher cardiovascular and overall mortality than previously suspected.
Subjects with normoglycemia also lost less whole-brain volume and exhibited lower conversion from MCI to AD.
Subjects with nuclear cataract grades @number@ or more ( @percent@ of the sample ) were excluded.
Subjects with @number@ - @number@ diseases were classified as relatively healthy and with > @number@ diseases as multimorbid.
Subjects with @number@ @number@ or @number@ healthy lifestyle behaviours had a significantly @number@ @number@ and @number@ % reduced risk of death , respectively.
Subjects with NWO had higher rates of abnormal cardiovascular risk factors.
Subjects with ocular disease that could possibly affect their IOP were excluded.
Subjects without ThAbs in this population sample are relatively older.
Subjects with PD were grouped according to treatment ( dental prophylaxis , intensive treatment , and PD without treatment ) .
Subjects with PD were tested under two medication conditions.
Subjects with pre-diabetes might nevertheless profit from preventive efforts reducing their cardiovascular risk profile because cardiovascular and kidney disease share common risk factors.
Subjects with rheumatoid arthritis , traumatic history , and severe degenerative changes in the upper cervical spine were excluded.
Subjects with RSWA but no abnormal REM sleep behaviors were diagnosed with subclinical RBD.
Subjects with STDE expressed lower CBF in left frontal , temporal , inferior parietal regions and bilateral superior parietal regions compared to men without STDE.
Subjects with stroke or neurodegenerative diseases other than Alzheimer's disease were excluded.
Subjects wore accelerometers and cellular network-based tracking devices over @number@ days of normal activity.
Subjects wore a heart sound / ECG / respiratory monitor.
Subjects wore a portable 5-lead electrocardiogram holter for @number@ h ( @number@ h prior to and following a maximal aerobic capacity test ) .
Subjects wore a uniaxial accelerometer ( Actiwatch ) , resulting in the measurement of actigraphic activity counts ( AC ) .
Sub-lethal and prolonged low doses of oxidative stress considerably accelerated telomere attrition.
Sub-lethal and prolonged low doses of oxidative stress considerably accelerated telomere attrition.
Sublethal dosage of NSC @number@ and the chemotherapy drug topotecan acted synergistically to inhibit cell proliferation and induce DNA damage.
Sub-lethal doses of oxidative stress induced cell-cycle arrest , senescent-morphological features and senescence-associated β-galactosidase positivity.
Sub-lethal doses of oxidative stress reduced proliferation rates and induced senescent-morphological features and senescence-associated β-galactosidase positivity.
Submaximal aerobic capacity was tested by a calibrated cycle ergometer with a commercial program ( Aino Fitware pro , Helsinki , Finland ) .
Submental muscular medialization and suspension is a simple yet highly effective surgical technique that can result in dramatic and enduring improvement in the cervicomental angle.
Submissions own research confirm this position.
Sub-network analysis led us to identify Bcl-xL as an important gene up-regulated in centenarians.
Suboptimal guideline adherence and underuse of anticoagulants in patients with atrial fibrillation ( AF ) have been reported worldwide.
Suboptimal health status questionnaire-25 ( SHSQ-25 ) was used in the community-based health survey.
Suboptimal health status ( SHS ) has been linked to cardiovascular risk factors , psychosocial stress , and unhealthy lifestyle.
Suboptimal interactions with providers are one such challenge.
Suboptimal percentages had claims indicating recommended exams were performed.
Suboptimal platelet inhibition was defined as on-treatment aggregation above the lower limit of normality.
Suboptimal platelet inhibition was found in @number@ patients ( @percent@ ) for ASA and for ADP antagonists in @number@ patients ( @percent@ ) .
Subperiostal mediofacial lift allows outstanding results at the cost of a certain technical aggressiveness.
Subplatysmal preparation and disconnection of the cranial-platysmal border permits optimal modeling of neck structure.
Subregional variations in forniceal diffusivity may exist , given its heterogeneous anatomy and connectivity ; however , these have not been closely examined in vivo.
Subsamples of @number@ older adults from the Medical Expenditure Panel Survey were selected for analyses.
Subsequent analyses based on the partial credit model explored the internal structure of eHEALS data.
Subsequent analyses included Sanger sequencing , in silico analyses , real-time PCR , and CCDC53 immunoblotting.
Subsequent analyses revealed verbal parent-child interactions have similar effects on Verbal Comprehension scores and rGMD in the right STG in both cross-sectional and longitudinal analyses.
Subsequent analysis indicated substantial shared variance among the covariates race and both measures of spectral-pattern discrimination in accounting for cognitive performance.
Subsequent analysis with a murine trauma model also demonstrated that elderly mice had increased mortality after posttrauma Pseudomonas pneumonia.
Subsequent behavioral studies revealed that the APP / PS1 / htau mice showed reduced mobility in old ages and exaggerated fear response.
Subsequent comparison between the @number@ timepoints revealed that patients with PD displayed further decreases in functional connectivity independent of aging effects.
Subsequent dramatic headlines and media stories have called into question the integrity of researchers and clinicians and undermined public faith in medical research.
Subsequent exploratory analyses suggested that AIM-induced reductions in adolescents ' anger served as a mediator connecting group assignment to TL.
Subsequent ex-vivo analyses examined serum PRX concentrations , striatal neurotransmitter content , and regional serotonin and dopamine transporter ( SERT , DAT ) binding density.
Subsequent FLCN sequencing identified an intronic c.1177-5 -3delCTC alteration that most likely affected the correct splicing of exon @number@ of the FLCN gene.
Subsequent hemolysis due to storage conditions and / or hemolytic disorders may have some pathophysiological consequences as a result of the release of Hb.
Subsequent histopathological analysis suggested the presence of a cardioprotective effect associated with the restoration of ovarian influence.
Subsequent investigation ruled out the role of DNA damage and classical p53 and p16 ( INK4a ) signaling in hSKP senescence.
Subsequent in vitro studies demonstrated that normal hepatocytes but not other non-parenchymal liver cells responded to bile acids with inflammatory cytokine induction.
Subsequent in vitro studies demonstrated that the expression of NRF2 significantly increased the proliferation activity of MCF7 and SK-BR-3 breast carcinoma cells.
Subsequently , aortic mechanical reserve is exhausted , and aortic remodeling with wall stiffening and dilatation ensue.
Subsequently , a parameter ( ΔE ) that was proportional to the perceived color differences was defined.
Subsequently , a screening procedure for five SIRT1 activators and the metabolite M1-SRT1720 in DBS specimens was developed.
Subsequently , atrophy appears to subsume the MTG.
Subsequently , autophagosomes communicate with the lysosomal compartment and acquire acidic hydrolases for final cargo degradation.
Subsequently , baseline levels of IgG anti-CMV antibodies were measured using an automated chemiluminescent microparticle immunoassay.
Subsequently brains were cut and stained with Luxol fast blue , Perls stain , and immunohistochemistry for substance P and calbindin.
Subsequently , completed surveys are transposed into a database for analysis and reporting.
Subsequently , confirmatory factor analysis was used to test for measurement equivalence across the three perspectives.
Subsequently , dosage of exercise and the molecular signaling pathways involved in its adaptations are discussed.
Subsequently , Epo from the hepatocytes stimulates erythropoiesis in the fetal liver of later stage embryos in a paracrine manner.
Subsequently , functional connectivity was computed between all ICs in each of the tasks.
Subsequently , further studies are necessary to clarify the incidence of acute myocardial infarction in old people.
Subsequently , he developed sensory disturbance in his lower limb.
Subsequently , inhibitory compounds are analyzed in a similar complementation assay in living cultured mammalian cells to select for those that can penetrate cells.
Subsequently , JMATs II have been providing long-term continuing medical support to disaster-affected areas.
Subsequently , latanoprost showed a neuroprotective effect , an additional pharmacological action.
Subsequently , more studies have evaluated the relationship of regional adiposity with BMD , and findings were inconsistent for central obesity.
Subsequently , neuropil rarefaction appears , followed by neuron loss.
Subsequently , new artificial tear products are developed that specifically target this pathomechanism.
Subsequently , ( @number@ ) F-FDG was used for imaging various cancers , such as lung , pancreas , colorectal and hepatoma.
Subsequently , @number@ of them were treated with BoNTA.
Subsequently , participants carried out the tasks in the apartment with the aid of their formulated plan ( execution stage ) .
Subsequently , participants classified novel strings as grammatical or nongrammatical.
Subsequently , participants completed the two depression screening questions and the 15-item version of the Geriatric Depression Scale ( GDS-15 ) .
Subsequently , population pyramids and structure indicators were constructed for each group of municipalities for two comparative reference years ( @number@ and @number@ ) .
Subsequently , preparation was started by carefully reviewing and selecting instruments to measure a wide set of health variables to answer the research questions.
Subsequently , regions of drusen are identified though a maximal region-based pixel intensity approach via RGB and HSV channels.
Subsequently , relative power values were correlated with neuropsychological tests scores and hippocampal volumes.
Subsequently , residents not enrolled in qualified plans at the start of the next year were rerandomized.
Subsequently , risk factors of AII were examined using multivariable logistic regression models.
Subsequently , specimens were sectioned serially and stained.
Subsequently , the difference between patients with presbylarynx and @number@ vocally healthy elderly subjects were assessed with multivariate analysis.
Subsequently , the FVR and BP measurements were again performed at @number@ @number@ @number@ @number@ and @number@ min of recovery ( postintervention ) .
Subsequently , the graph metrics and the connectivity within and between modules were related to cognitive performance.
Subsequently , the measurements were again performed at @number@ @number@ @number@ @number@ and @number@ minutes of recovery ( post-intervention ) in the supine position.
Subsequently , the performance of high-intensity exercise tasks , which rely heavily on the creatine-phosphocreatine energy system , is enhanced.
Subsequently , these women kept a diary to record menstrual bleeding and intercourse and conducted standardized pregnancy testing for up to @number@ months.
Subsequently , the three sensors dimerize and autophosphorylate to promote the signal cascades of ER stress.
Subsequently , the volume of the testes stabilizes in a plateau-like manner until age @number@ years.
Subsequently , they completed a thermal pain threshold and tolerance task.
Subsequently , we examined in a subset of the study the expression in blood of two genes regulating mitochondrial biogenesis , YY1 and PGC-1α.
Subsequently , we investigated proximity and lobar distribution in strata of APOE genotype.
Subsequently , we measured APH-1A mRNA and protein levels and γ-secretase activity in C or G allele carriers.
Subsequently , we performed neurobehavioral tests and quantitative immunohistochemistry to assess effects on AD-related phenotypes , including learning and memory , and synaptic damage.
Subsequently , we sought replication in a non-overlapping set of @number@ participants.
Subsequent memory effects common to the @number@ age groups were identified in several regions , including left inferior frontal gyrus and bilateral hippocampus.
Subsequent nutrition education and follow-up may be important in preventing further decline.
Subsequent quartile comparisons suggested a concentration-dependent threshold with respect to evening testosterone.
Subsequent reactivation episodes occur , leading mainly to subclinical detection of VZV , but also to the clinical entity herpes zoster.
Subsequent responses , including alteration of mitochondrial biogenesis , mitophagy , apoptosis and paraptosis , participate in the aging process from different respects.
Subsequent studies identified similar indels in controls and suggested that these indels may confer susceptibility to ALS.
Subsequent studies in different ethnic populations have not reached any conclusive result about the role of CHCHD2 in PD.
Subsequent studies , with the exception of a few studies with modest numbers of patients , have confirmed the prognostic importance of the HCT-CI.
Subsequent surveys were used to define and prioritize modular continuing education topics suitable for web-based delivery.
Subsequent treatments of the same body location after a healing period of @number@ to @number@ months resulted in no greater risk of AEs.
Subsequent univariate analyses indicated that WMHs in the deep fronto-parietal and periventricular parieto-occipital regions had the strongest associations with physical decline.
Subsequent work could focus on defining inadequacy.
Subset analyses for colon and rectal cancers yielded similar , yet non-significant risk estimates at all five loci.
Subset analysis of monocyte , neutrophil , and T-cells supported these findings.
Subset ( n = @number@ ) had automated hippocampal volumetry.
Subsets of monkeys additionally had their intestinal motility , intestinal permeability , and fecal microbiomes characterized.
Subsite specific sensitivity for various types of colorectal neoplasms was derived by comparing FIT results with findings at screening colonoscopy.
Substance use disorders ( SUD ) , including alcohol and tobacco , have been associated with chronic , infectious diseases , and mental health disorders.
Substantial age- and AD-related alterations in Ca ( 2 + ) -sensing proteins most likely contribute to selective vulnerability of BFCN to degeneration in AD.
Substantial agreement in GMFCS ratings over time was achieved ( κ ( lw ) = 0.74-0.76 ) .
Substantial bias even persists if the initial years of follow-up are excluded from the analyses.
Substantial changes in population size , age structure , and urbanization are expected in many parts of the world this century.
Substantial cross-country variations were seen in the four health outcome measures.
Substantial differences between male and female heavy drinkers were found in sociodemographics , health status , and social support and social engagement.
Substantial differences between MCI and prevalent dementia reflected high inpatient costs for dementia and appear partly related to co-occurring mental disorders.
Substantial differences existed between men and women in terms of socio-economic status , education level and occupational status.
Substantial differences of radiation dose were observed between direct human- versus mouse-derived biokinetic data.
Substantial efforts have been made to predict ANM by using anti-Müllerian hormone ( AMH ) levels.
Substantial evidence demonstrates that failure of microglia to clear abnormally accumulating amyloid-beta ( Aβ ) peptide contributes to neuroinflammation and neurodegeneration in AD.
Substantial evidence from studies in yeast has shown that SUMOylation plays an important role in the regulation of DNA replication and repair.
Substantial evidence has accumulated linking epigenome change to alterations in stem cell function during postnatal development and aging.
Substantial evidence indicates that disrupted neuronal calcium homeostasis is an early event in AD that could mediate synaptic dysfunction and neuronal toxicity.
Substantial evidence suggests heightened inflammatory state and significant immune system alterations in frailty.
Substantial funding has also been received from the Michael J. Fox Foundation for Parkinson's Research.
Substantial general transfer effects were found for the trained group , but not for the control one.
Substantial IAT scores and quad processes except guessing varied with age.
Substantial improvements have occurred in the longevity of several groups of individuals with early-onset disabilities , with many now surviving to advanced ages.
Substantial improvement was offered by using three CCA diameters , with only minor further improvement using five CCA diameters.
Substantial individual differences exist in the magnitude of the cognitive decline associated with normal aging.
Substantially elevated brain iron was found in AUD subjects in the basal ganglia and dentate nucleus.
Substantially more variability was observed in the pattern and magnitude of children compared with adults , which may be interpreted as proxy for developmental change.
Substantial progress in the understanding of the biology of Alzheimer's disease ( AD ) has been achieved over the past decades.
Substantial progress of genomic studies in genetic of aging processes , including complex metabolic processes and gene regulation is outlined.
Substantial resources have been devoted to researching this disease , and rich multimodal data resources have been generated.
Substantial sexual differences were found in the overhead but not in the first-person view APTT version.
Substantial variability is associated with laboratory measurement of serum total 25-hydroxyvitamin D [ 25 ( OH ) D ] .
Substantial variation in discharge destination and LOS remained after adjusting for demographic and clinical characteristics.
Substantial variation of CRC survival between European countries and between age groups persisted and even tentatively increased over time.
Substituting @number@ min / day of weight training for any other discretionary activity had the strongest inverse association with WC change.
Substrate proteins of the canonical UPP are first tagged by multiple ubiquitin molecules and then degraded by the 26S proteasome.
Substrate selectivity is mainly provided by the group of E3 enzymes.
Substrate sensitivity for octanoyl-carnitine did not differ between groups.
Subtle changes in memory , attention , and problem-solving abilities may negatively influence an individual's ability to adopt positive health behaviors.
Subtle cognitive deficits have been described in narcolepsy.
Subtle or conspicuous \ "picture-frame \ " appearance may also be identified.
Subtotal BMD was calculated by subtracting head BMD from total BMD along with whole body measurement.
Subtotal parathyroidectomy was mostly reserved for younger patients suitable for kidney transplantation.
Subtypes did not differ on age , education , income , marital status , living arrangements , or years in the USA.
Subtype selectivity of inhibition is lost during long-term use of ' selective ' monoamine oxidase inhibitors.
Subtypes of concordance and discordance provide a more holistic biopsychosocial conceptualization of successful aging.
Subtypes of dementia and MCI were similar to those in younger populations.
Success at crossword puzzles taxes several aspects of memory and cognition.
Successes include improved community relations , increased opportunities for education and employment and rewarding partnerships , while insufficient funding was a commonly identified challenge.
Successful accommodation was associated with maintaining participation in valued activities and high well-being , but substantial disparities by race , ethnicity , and income existed.
Successful ageing is not only about the maintenance of health , but about maximising one's psychological resources , namely self-efficacy and resilience.
Successful ageing was defined through health status and well-being.
Successful agers had less co-morbidity and a lower risk of falls or malnutrition , and they had higher scores on the QoL scale.
Successful aging in place encompasses safety , health , and economic security.
Successful aging is important ; however , there is a lack of knowledge on how to promote successful aging in Black older adults.
Successful aging was defined as absence of disease , adequate physical function , high quality of life ( QOL ) , and social engagement.
Successful care of a stroke patient begins with recognition by the public and health professionals that stroke should be considered an emergency.
Successful educational interventions are described , including the authors ' experience at the helm of a monthlong geriatrics clerkship for fourth-year medical students.
Successful execution of motor tasks requires an integration of the perception of one's physical abilities and the perception of the task itself.
Successful free tissue transfer was achieved in @number@ of the @number@ flaps.
Successful human social interactions depend upon the transmission of verbal and non-verbal signals from one individual to another.
Successfully , the newborn survived and it was further investigated to exclude this condition.
Successful management of the underlying disorder often resolves orgasmic disorder.
Successful mobility requires appropriate decision-making.
Successful naming rates correlated positively with white matter integrity across a broad range of regions implicated in language production.
Successful PAV deployment and function are heavily reliant on the tissue-stent interaction.
Successful performance of a memory-guided motor task requires participants to store and then recall an accurate representation of the motor goal.
Successful perioperative respiratory care of the geriatric patient relies on careful risk assessment and optimization of pulmonary function and support.
Successful regeneration of a functional organ relies on the organized and timely orchestration of molecular events among distinct stem / progenitor cell populations.
Successful repair of the I-SceI-induced breaks by NHEJ or HR restores the functional GFP gene.
Successful reproduction is the result of a myriad interactions in which the ovary and the ovarian follicular reserve play a fundamental role.
Successful reprogramming of differentiated human somatic cells into a pluripotent state allows creation of patient- and disease-specific SCs.
Successful resolution of HSDD frequently facilitates resolution of other disorders.
Successful results from a previous RCT were able to be translated into community settings , with a similar magnitude of effect on balance and mobility.
Successful smoking cessation was defined as a minimum of @number@ smoking free days during follow up.
Successful translation of this technology in the clinic could serve as a sensitive diagnostic tool for the definition of effective therapeutic windows.
Successful treatment may either increase the ability to cope with the problem or may be curative.
Successful treatment of depression has beneficial effects on sleep outcomes in these patients.
Successful treatment of these diseases could benefit from cell-based therapy that would regenerate lost cells or otherwise restore tissue function.
Success is \ "hit or miss \ " and the lessons learned are largely anecdotal to date.
Successive cyclic loading to a uniform level of stretch softened BVs with decaying peak stresses , and shifted their stress-stretch relationship.
Successively smaller lines were read until a participant could no longer read any of the letters correctly.
Success rate of the VCG task decreased during walking , but only for OG.
Success was accessed by ( @number@ ) C urea breath test @number@ months after the end of treatment.
Such account grew to the point of inspiring , on speculative grounds , possible roles in the organization of the cerebral cortex.
Such a collection offers an additional to the international research community to advance the understanding on neuropsychiatric diseases.
Such a conceptualization might eventually encourage key stakeholders to combine their efforts in approaching the sarcopenia condition.
Such a correlation was not observed in a population from northern Italy that we used as an independent replication set.
Such activities should also include optimizing the children and youth training in these disciplines , where an early specialization operates.
Such activity was abrogated by modification of plasminogen structure and interference of PrP-plasminogen interaction.
Such activity was quantified at pH @number@ in ovarian epithelial cells from @number@ donors without a history of cancer , by the chemoluminiscent method.
Such a decrease may be considered as a potential biomarker of underlying neurodegeneration.
Such adrenocortical remodeling is ascribed to high-sodium / low-potassium diets.
Such advances , to a significant extent , can be attributed - up to @percent@ of the total - to the results of pharmaceutical research.
Such a framework would provide the necessary unifying context for a more powerful explanatory account.
Such an adaptation to increased loading did not occur in the older GM muscle.
Such analyses will serve as the foundation for better understanding of dopaminergic development , function , and development of future stem cell-based therapies.
Such an approach may reduce disability and the risk of hospitalization and increase functional independence and quality of life.
Such an association per se does not imply that CKD is a causal determinant of CVD.
Such an association was not found among women in this study.
Such an effect was markedly enhanced by glycated forms of the protein.
Such an effect was not associated with a significant difference in systolic blood pressure ( SBP ) decrements between the younger and older groups.
Such an effect was reverted by exogenously added Cbln4.
Such an estimate will help determine if women are candidates for preventive measures and specific therapies such as aspirin.
Such a network-based approach considerably increases the opportunities for targeting DNA repair-defective tumors.
Such a network representation of brain connectivity has provided a novel means of investigating brain changes arising from pathology , development or aging.
Such an impending situation may be associated with multiple medical , social and economic issues.
Such antibodies block cell adhesion and Gal-8-induced Th17 apoptosis.
Such an understanding is also crucial for designing interventions and preventive measures for successful brain aging.
Such a personalized approach may be more sensitive to gender differences and to the impact of psychiatric co-morbidities and medications.
Such apparently irrelevant immune activity unprovoked by an exogenous infectious agent characterizes the aging brain and is even more pronounced in several neurodegenerative diseases.
Such approaches miss the opportunity to systemically integrate the phenome-wide data available for genetic association analysis.
Such a process is likely to increase the present nursing shortage and so to endanger the care access for a part of the population.
Such a programming effect of milk intake in early life could potentially have implications for cancer and ischemic heart disease risk many years later.
Such a regulation is not in place in China yet , and CCA-treated wood is widely used in public parks.
Such a regulatory system has caused more than several years of approval delays compared to delays in other countries.
Such a role can be counteracted during RRMS by anti-Gal-8 antibodies , worsening disease prognosis.
Such a senescence rate is generally estimated from parameters of a mathematical model fitted to these mortality rates.
Such a situation suggests that both paediatric and adult physicians might be interested in adolescent and young adult medicine training and practice.
Such associations were less prominent in the younger group.
Such a structure might be important for telomere biology and a good target for drug design.
Such a study has two components facial age estimation and age-separated face recognition.
Such a trained system can then be used to classify unseen texts.
Such biases survived a stringent statistical correction and were largely confirmed in a voxel-based analysis.
Such biomarkers merit evaluation in clinical trials.
Such care can occur on a daily basis leaving little opportunity for the caregiver to take care of himself / herself.
Such cell damage very likely underlies the serious adverse effects of blood transfusion.
Such cells have provided a potential resource for stem cell therapy and regenerative medicine.
Such changes appear much alleviated by a daily strong photo-protective regimen.
Such changes can potentially affect the epigenetic patterns and levels of gene expression , and ultimately the phenotypes of cells.
Such changes in collagenous skin tissues have been suggested to be causes of cutaneous aging and skin cancer.
Such changes may impair the use of adipose tissue as source of autologous PCs in elderly patients.
Such circumstances lead to rapid skeletal muscle atrophy , loss of functional strength and a multitude of related negative health consequences.
Such combinations lead to a worsening of the overall prognosis.
Such comparisons can help inform models aimed at identifying where , when , and for which individuals proposed interventions might be cost-effective.
Such concepts are multi-faceted in nature and have important practical implications in areas such as time management , financial planning , or medical choices.
Such conditions tip the immune balance in favor of altered T cell activation and a related decreased response in aging.
Such constraints should be accounted for in the analysis.
Such counterbalance was not observed in the older group.
Such data is deposited into data repositories such as the Gene Expression Omnibus ( GEO ) for potential reuse.
Such data may be of value to physicians and their patients who are considering reproductive options.
Such data provide a window into the microevolutionary dynamics that drive successful immune responses and the dysregulation that occurs with aging or disease.
Such data suggest that humor processing undergoes developmental changes and is moderated by higher IQ scores , both factors likely improving incongruity detection and resolution.
Such DDIs are common.
Such declines observed with aging may result from multiple but minor sensory and motor deficits.
Such deficits could contribute to functional deficits and a poorer response to rehabilitation.
Such definitions may need to differentiate between \ "Longevity Syndrome \ " and \ "Exceptional Longevity \ ".
Such delay may be associated with the inability to react and recruit muscles quickly.
Such detection may be biased , as some factors and their modifications may not reflect physical DNA damage.
Such differences equate to estimated reductions in odds of depression by @percent@.
Such differences may contribute to the predisposition of primary open-angle glaucoma in various high-risk populations.
Such differences should be considered in future investigations assessing aortic atherosclerosis and the effects of anti-atherosclerotic therapies.
Such differential utilization appears mainly attributable to inequalities in preventive dental visits , either alone or in combination with operative treatment.
Such discrepancy is more prominent in older patients.
Such disorders result from abnormal expression and distribution of connexins , the major constituents of cardiac gap junction channels.
Such drugs should be known by practicing cardiologists for their possible use in ICUs in the years to come.
Such effectiveness might be specifically important to patients with poor oral intake because of nausea , vomiting , or chemotherapy-associated mucositis.
Such effect of amplification of inflammatory response may explain the higher risk of chronic diseases observed in subclinical hyperuricemia in observational studies.
Such effects refer to men older than @number@ years and may have impact on socio-economic issues.
Such effects were generally absent among those born into landowning families.
Such effects were more evident in viscera than in skin.
Such efficient in vitro glycation of older cortical bone could result from aging-related increase in porosity caused by the loss of mineral content.
Such electronic technologies could potentially benefit the growing population of patients with multiple chronic conditions ( MCC ) .
Such ERPs , however , comprise various components reflecting different aspects of auditory and task-related processing.
Such evaluation can increase the possibility of detecting wall stiffness and atherosclerosis in its early stage.
Such events eventually lead to activation of cell death pathways and to an aberrant aggregation or incorporation of ubiquitinated proteins into hallmark structures.
Such evidence may inform future studies focused on cognitive decline in aging.
Such executive functions include problem solving , planning , dividing attention and inhibiting responses.
Such factors include inflammatory markers and vascular factors , which might also directly contribute to ARHI.
Such features were present nearly uniformly in the LM and LMM specimens.
Such findings begin to delineate the noncognitive course of Alzheimer disease dementia in the preclinical stages.
Such findings can facilitate development of screening processes to identify families at-risk following institutionalization.
Such findings challenge the proposed sequence and suggest that Aβ-independent precursors underlie AD-typical neurodegenerative patterns.
Such findings have important implications in dosing drugs cleared by the kidney.
Such findings have profound implications for the stem cell-based therapy of age-related diseases.
Such findings may have implications for the clinical management of the individual patient.
Such findings must be interpreted with care in children with suspected disease such as juvenile arthritis.
Such findings need replication in an independent cohort.
Such findings provide the foundation for the model of hemispheric asymmetry reduction in older adults , or \ "HAROLD \ " [ @number@ ] .
Such findings suggest that young and older adults may differentially access and / or weight different kinds of information in making vividness judgments.
Such findings underscore the relevance of information processing for the ownership of technological devices in late life.
Such findings were partially mediated by age-related increases in the structural connectivity of the occipital lobe within the posterior brain.
Such functional divergence has important implications in promoting behavioral isolation across short- and long-term timescales.
Such functional impairment of the effector response may be a useful indicator for predicting clinical prognosis and recommending starting or stopping secondary prophylaxis.
Such gait changes are often too discrete to be detected by clinical observation alone.
Such glomeruli might be considered as hypertrophic.
Such highly structured tasks may not be representative of the processes at work under more natural word retrieval conditions.
Such histological sections enable microstructural analyses and anatomical evaluations of functional and structural neuroimaging data , for example , based on magnetic resonance imaging.
Such hyperpolarization could happen because of artificial activation of cellular response to caloric restriction in the absence of energy deficit.
Such important diseases as chronic heart failure , diabetes mellitus , chronic pulmonary obstructive disease have the high risk of disability.
Such individuals may have an increased risk for injury to self or others through self-neglect as a result of the CI symptoms.
Such influences lead to a certain experimental variability in inter-person and intra-person variation , which is higher than the inter-finger and intra-finger variation.
Such information assists in counseling patients and family members and can guide therapeutic decisions.
Such information can be used for benchmarking and to identify gaps in diabetes detection and management.
Such information can help healthcare professionals to maintain long-term autonomy of elders in self-care and to promote healthy aging.
Such information could be used in the creation of a pathologic ' staging ' of WMSA through a detailed regional characterization at the individual level.
Such information could be used to tailor intervention strategies to reduce harmful consumption.
Such information is crucial to elucidating mechanisms underlying arterial stiffness and the design of interventions to retard it.
Such information is crucial to medical experts that target site-specific bone loading through exercise in elderly populations in order to prevent hip bone loss.
Such information is essential to identify potential problems and to inform targeted intervention strategies.
Such information is very scarce.
Such information will also provide the additional guidance necessary toward a personalized nutritional advice to reach sufficient vitamin D status.
Such input should be considered as research institutions respond to changes in biorepository regulation.
Such insidious processes may affect human health , fitness and ultimately may limit our lifespan.
Such insights can be utilized to detect person-specific critical periods and for designing immediate person-specific interventions.
Such insights will help health systems internationally as they grapple with the issue of ALC whilst trying to optimize engagement with patients and their families.
Such intervention may deserve further consideration in clinical practice.
Such interventions also may reduce gender gaps in later-life disability and self-rated health.
Such interventions have also been successful in mammals , proving the principle that discoveries in invertebrates can be evolutionarily relevant to humans.
Such interventions must engage with the power dynamics , values , interests and institutional factors that mediate the path by which science shapes government budgets.
Such investigations have thus far been small , and unblinded.
Such isolation could be prevented by monitoring at-risk individuals at the neighborhood level and by implementing supportive networks at the community level.
Such is the case for the DNA replisome responsible for copying the genetic information that provides the recipe of life.
Such knowledge can then be used to provide therapeutic targets aimed at managing obesity-linked diseases including type @number@ diabetes and metabolic syndrome.
Such knowledge is important since several of its side effects are dose dependent.
Such knowledge shall constitute an important starting point toward the goal of modifying AHN in neurodegenerative or psychiatric diseases.
Such knowledge will undoubtedly lead to new drugs that better prevent or reverse left ventricular hypertension.
Such knowledge would assist healthcare practitioners in advising patients on a suitable choice of device.
Such LHON lessons are actively being applied to common ophthalmological diseases like glaucoma and neurological diseases like Parkinsonism.
Such MAOA carriers may have higher negative urgency , which may in turn predict greater aggressive responses to provocation.
Such markers are , however , valuable in aging research.
Such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints.
Such markers may reflect and / or be a proxy for the core biology of suicide.
Such mechanisms include DNA methylation as well as modifications of histones and microRNAs ( miRNAs ) .
Such mechanistic insights will facilitate strategic interventions that prevent accelerated metabolic decline and the premature onset of T2D in the current and future generations.
Such membranes include the bacterial plasma membrane and IMM.
Such mentorship may be particularly relevant to promoting their interest in geriatrics.
Such methodology would also be potentially useful to address a number of difficult problems in clinical dermatology , such as ageing and itching.
Such methods are an essential step in computational pipelines and provide anatomically comparable measurements across a population in atlas-based studies.
Such methods could ultimately be used to noninvasively monitor muscle health and fitness.
Such methods have up to now mainly been applied to complex mixtures of glycoproteins in biofluids ( e.g. plasma ) .
Such models can be used to estimate the cumulative risk of developing dementia in the presence of the competing risk of dementia-free death.
Such modifications limit blood and oxygen supply to the cortex , possibly resulting in energy failure and neuronal death.
Such modifications make the appearance of this sufferance , diagnose , and treatment to be complex and different in the rest of the population.
Such molecular knowledge may pave the way to methods for maintaining short-term tissue reconstitution while retaining long-term cellular and genomic integrity.
Such monitoring could potentially predict decline of brain function.
Such mtDNA content increase correlated with the levels of the @number@ bp deletion and with cancer stage ( p < @number@ ) .
Such multifactorial effects of vitamin D3 can be a profitable source of new therapeutic solutions for two radically divergent diseases , cancer and neurodegeneration.
Such nature of the dynamics on the same type of repetitive exposure indicates change in adaptation strategies.
Such need arises in functional neuroimaging studies , where individual differences in cognitive performance are variables of interest or serve as confounds.
Such networks will be useful to future comparative studies of complex effects of polyphenols.
Such neurotransmission deficits are not seen at either noradrenergic or serotoninergic terminals.
Such non-AIDS-defining comorbidities include cardiovascular disease , dyslipidemia , osteoporosis and frailty , and are of increasing importance with improved survival on antiretrovirals.
Such novel interventions may be particularly helpful for older adult implant users.
Such oxidative stress brings damage by oxidation of cell components such as lipids , proteins , and DNA.
Such parallels are used to support the universal applicability of the metrics and the methodology presented in this paper.
Such patients are more prone to develop painful and debilitating spinal deformities but are difficult to treat.
Such patients often have complicated clinical courses and ultimately die of infection and sepsis.
Such performance monitoring abilities undergo maturational and aging-related changes across the lifespan.
Such physiological variations should be considered when interpreting pathologic changes of the choroid.
Such processes are involved in the regulation of tissue-specific gene expression , cell differentiation and genomic imprinting.
Such profiles could guide the ideation of effective preventive strategies and / or targeted early lifestyle or therapeutic interventions.
Such profiling has implications for disease prevention and treatment.
Such programmes can serve to ensure the quality of life of long-lived seniors.
Such programs could be provided through the Internet , but that could result in the exclusion of cancer survivors not familiar with the Internet.
Such progress of accumulation of Aβ on photoreceptor outer segments with age was also confirmed in human retinae using immunohistochemistry.
Such projects require multidisciplinary teams with expertise in the many health and contextual factors that must be considered.
Such properties may impact on the risk diseases which predominate in older people , and also ageing-related physiological changes.
Such protective factors may ' buffer ' the effects of specific risk alleles.
Such redox dysregulation can result from many cellular events , including hyperactivation of the N-methyl-D-aspartate-type glutamate receptor , mitochondrial dysfunction , and cellular aging.
Such regimens generally result in temporary WM benefits to the trained tasks but minimal transfer of benefit to untrained tasks.
Such relationship is maintained over time.
Such reproductive senescence in mid-lifespan is an evolutionary puzzle of enduring interest because it should be inherently disadvantageous.
Such research is needed for understanding and planning health expenditures.
Such research will guide physical activity approaches aimed at facilitating enhanced physical and mental health outcomes in individuals with schizophrenia.
Such result requires further investigation , especially concerning the role of these asymmetries for development of articular injuries.
Such results strongly indicate the key importance of oocyte quality for a successful clinical outcome in egg sharing practices and assisted reproduction treatment more generally.
Such results will be achieved only through long-term interventions.
Such risk is of alarming concern due to the high disability and mortality rates associated with falling in older adults.
Such roles may contribute to the overall longevity and health of the organism.
Such secrecy obligation implies a well-designed and secure system for data storage.
Such sedentary activity in older adulthood is thought to risk deterioration of physical and mental functioning , health and wellbeing.
Such selectivity should translate into a favorable clinical safety profile.
Such signal molecules as tumor necrosis factor ( TNF-alpha ) , interleukins-1 , 6 ( IL-1 , 6 ) take part in these processes.
Such specific Runx requirements have been unveiled by a series of cell type- , developmental stage- or age-specific gene targeting studies in mice.
Such strategy can be valuable if helping to improve postural control in the elderly.
Such strategy may reflect age-changes in the relative costs and benefits of different regional tissue masses.
Such striking similarities indicate that lifespan is strongly dependent on autophagy.
Such studies are relevant to establish LTL dynamics as biomarkers of mortality as well as to disentangle the causality of telomeres on aging.
Such studies could improve our understanding of the development and fluctuations in back pain , and therefore influence treatment approaches.
Such studies could prove very valuable in studies of the mechanisms of cancer development , aging , and other processes of disordered genomic functioning.
Such studies may provide an insight in developing therapeutic strategies and may have clinical implications.
Such studies provide the rationale for use of Tβ4 in other types of eye disorders beyond dry eye.
Such subtypes may delineate groups of individuals that are more homogenous in terms of suicidality biology and behavior.
Such surveys reveal important information , however , are largely based on the concerns of providers as opposed to the concerns of residents.
Such techniques enable accurate and standardized assessments of patients ' performance and actions in real time and real life situations.
Such testing may have the potential to select / stratify patients in treatment trials of cognitively impaired patients or prevention trials in cognitively intact individuals.
Such therapies may represent effective strategies in the future management of SBP.
Such \ "thinking inside of the brain \ " may further expand our understanding of the brain to improve our clinical interpretations and treatments.
Such tradeoffs may result from underlying intertwined homeostatic mechanisms.
Such translational research can help to guide the dissemination of additional state-wide health promotion programs for older women.
Such trends have raised concerns about live disenrollment's effect on care quality.
Such type of study could help in the choice of targeted sanitary protection procedures and for further toxicological investigations.
Such variability is likely caused by ethnic differences between the populations studied.
Such Web-based interventions provide novel opportunities for large scale prevention of metabolic deregulation in our rapidly aging population.
Such well-intentioned studies would generate numerous data , but render SD a scientific and logical enigma.
Sudden cardiac death ( SCD ) occurs in approximately @number@ cases per @number@ persons annually in each country of Asia.
Sudden death is the leading cause of late mortality , although therapeutic advances may alter this profile.
Sudomotor nerve fiber loss correlated with ENF density ( p < @number@ ) and sweating output ( p < @number@ ) .
Sufentanil is a potent synthetic opioid.
Sufferers of respiratory diseases may exhibit exacerbated symptoms due to altered environmental conditions ( e.g. , pollen ) .
Suffering a stroke can be a devastating and life-changing event.
Suffering from comorbidity and functional limitations were each associated with considerably lower perceived control.
Suffering related to dementia is multifaceted because cognitive and physical functioning slowly deteriorates.
Sufficient amount of intravenous extracellular fluid and constant infusion of insulin are essential.
Sufficient antigen-specific B cell memory B generated by adequate priming and consecutive booster vaccinations and / or exposure is a prerequisite for long-term protection.
Sufficient cerebral blood flow ( CBF ) and venous drainage are critical for normal brain function , and their alterations can affect brain aging.
Suffocation is a suicide method that is highly lethal , requires relatively little planning , and is readily available.
Sugar-sweetened beverages were not associated with stroke or dementia.
Suggested sex differences deserve further study.
Suggested strategies include group photovoice experience and the expansion of reflection to enhance rural health research.
Suggesting that reducing the risk of food intolerance , keeping the suitable weight was necessary.
Suggestions for clinic implementation and ongoing capacity building were identified.
Suggestions for future research are discussed.
Suggestions for future research , the utility of varied measurement instruments , and implications for practice are discussed.
Suggestions for future research with adolescents and a proposal for a guiding model are provided.
Suggestions for how this domain needs to progress are also summarised.
Suggestions for improvements were noted and incorporated into the online tool.
Suggestions for medication adjustments were also frequent.
Suggestions for new recommendations are given.
Suggestions for person-tailored interventions may be based on these risk profiles.
Suggestions to improve practice guidelines in the management of diabetic patients with sleep apnea are provided.
Suggestions to improve the reproducibility of this emerging field are provided , including the adoption of a trans-diagnostic approach.
Suggestive evidence was also found for eye-hand coordination ( P = @number@ ) .
Suggestive results from Stage @number@ from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset.
Sugihara causality between the channels is described by a quality score based on comparison between the reconstructed signal and the original signal.
Suicidal behavior is a potentially lethal complication of late-life depression.
Suicide cases were not more likely to be short of breath or poor sleep quality.
Suicide methods differed between gender and age groups.
Suicide rates of men aged 45-64 in Australia and US also fell , though by 2009-13 the US rate had risen again.
Suicide-related variables and predictive factors associated with significant suicidal ideation were compared between the two groups.
Suicide remains a clear , present and increasing public health problem , despite being a potentially preventable tragedy.
Suicide risk is particularly high in the first @number@ years following stroke.
Suicide tends to increase with age in most countries.
SUI is associated with pelvic floor debility , absence of detrusor contraction , or a loss of control over the sphincter muscle apparatus.
Suitability for inclusion was evaluated through interview , based on a questionnaire , and physical examination.
Suitable animal models are required to test this hypothesis.
Suitable music can positively affect people.
SUJECTS : one hundred volunteers aged 60-70 years.
Sulfate data was available for @number@ participants with @number@ observations.
Sulfatide is a major component of glycosphingolipids in lipoproteins.
Sulfur amino acids are determinant for the detoxification of paracetamol ( N-acetyl-p-aminophenol ) through sulfate and glutathione conjugations.
Sulfur dioxide exposure was found to be associated with earlier mean ANM in blue-collar workers.
Sulfur dioxide may be part of the reason that blue-collar workers experience earlier menopause than white-collar workers.
Sulfur mustard , an agent used in chemical warfare , is an alkylating substance with carcinogenic potential.
Summarizing it can be noted that the bioavailability of insulin administered via routes others than subcutaneously is comparably low ( max.
SUMMARY : A better understanding of the molecular mechanisms of platelet-related immune activity allows their utilization as powerful diagnostic tools or targets of therapeutic intervention.
SUMMARY : Additional research is needed to better define the role of the extracranial venous system in relation to CNS disorders and aging.
SUMMARY : Aerobic training among older adults with mild SIVCI can improve executive functions and neural efficiency of associated brain areas.
SUMMARY : Age-related hearing loss is a critical public health issue that affects almost all older adults.
SUMMARY : A growing elderly population is expected worldwide , and the burden of hip fractures on health care system will continue to increase.
Summary A high incidence of 25OH vitamin D deficiency has been observed in HIV-infected subjects.
SUMMARY ANSWER : AGEs might contribute to the etiology of polycystic ovary syndrome ( PCOS ) and infertility.
SUMMARY ANSWER : No clear evidence was provided that type @number@ diabetes is a determinant of accelerated ovarian ageing resulting in an early menopause.
SUMMARY ANSWER : Shortened telomere length and diminished telomerase activity were associated with biochemical POI.
SUMMARY : Antioxidant supplements do not possess preventive effects and may be harmful with unwanted consequences to our health , especially in well-nourished populations.
SUMMARY : ARHL is related to cognitive impairment and dementia.
SUMMARY : A statistically significant improvement in wrinkles , texture and fine lines was noticed in most subjects.
SUMMARY : A unified approach to defining , assessing , and stratifying pneumonia is essential to decrease morbidity and mortality in nursing home residents.
SUMMARY BACKGROUND DATA : Large volume pRBC transfusions are associated with multiple adverse clinical sequelae , including lung inflammation.
SUMMARY BACKGROUND DATA : Outcomes of HD extending to adulthood are unclear ; bowel function and quality of life may deteriorate by aging.
SUMMARY : Biomechanical evidence indicates that foot orthotics and specialized footwear may change muscle activation and gait patterns to reduce joint loading.
SUMMARY : B lymphocyte clones that were detected in human reactive lymph node tissues represent major responding clones in normal polyclonal immune response.
SUMMARY : BNP / NT-Pro-BNP assay has widespread utility as an adjunct to cardiovascular disease diagnosis and management.
SUMMARY : CKD includes a diverse group of individuals with reduced GFR from a variety of causes.
SUMMARY : Coffee and tea can generally be recommended as health-promoting additions to an adult diet.
SUMMARY : Complex epigenetic mechanisms are involved in aging and longevity , directly or indirectly via disease mechanisms.
SUMMARY : Contrary to conventional wisdom , chronological age is independently associated with adverse outcomes in patients with CAP.
SUMMARY : Current efforts aim at treating elderly PCNSL patients within clinical trials that are specifically designed for this group of patients.
SUMMARY : Current findings suggest that childhood development is strictly connected to psychiatric phenotypes across the lifespan.
SUMMARY : DXA and clinical fracture risk prediction tools are preferential markers of fracture risk.
SUMMARY : ECs provide a fertile niche for maintenance of functional HSCs throughout their lifecycle.
SUMMARY : Educational interventions with farmers have met with limited success in reducing farm-related injuries.
Summary estimates were derived using random effects models.
SUMMARY : Findings indicate that the logopenic variant is a distinct subtype of progressive aphasia that may hold value as a predictor of underlying pathology.
SUMMARY : Formation and role of RBC microparticles are far from being completely understood.
SUMMARY : Future epidemiologic and public health research should aim at sustaining a comprehensive systems view on health and disease.
SUMMARY : Ghrelin and GHS have the potential to effectively prevent or reverse CACS.
SUMMARY : Goals of diabetes care in elderly and younger adults are alike , though managing diabetes in elderly requires individualized approach.
SUMMARY : Hand radiographs are obtained routinely to determine bone age of children.
SUMMARY : Here , we review the recent developments in our understanding of signaling pathways required for podocyte function in health and disease.
SUMMARY : IM therapies are appealing to and utilized by many cancer survivors and may reduce symptom burden.
SUMMARY : In a select group of patients , thermotherapy and laser prostate surgery could be safely used to treat LUTS / BPH patients.
SUMMARY : Increasing numbers of ageing transgender individuals will be interfacing with health and care providers.
SUMMARY : In osteoarthritis , pain analysis should not be restricted to intensity.
SUMMARY : In this review article we will highlight possible new avenues using external physical and biochemical stimulation in order to optimize muscle bioengineering.
SUMMARY : In this review , the differential impact of uremia on the cellular immune system is summarized.
Summary : Mathematical models and their simulation are increasingly used to gain insights into cellular pathways and regulatory networks.
Summary measures across activities and several hierarchical classification schemes ( e.g. , no accommodation , devices / activity reductions only , help ) were developed.
Summary measures of long-term strenuous and moderate activity were constructed for each participant.
SUMMARY : Metabolic issues persist in HIV patients who are otherwise stable.
SUMMARY : Mild cognitive impairment as currently defined is still etiologically and prognostically heterogeneous , particularly outside specialty clinical settings.
SUMMARY : Morbidity in sarcoidosis is significant and multifactorial.
SUMMARY : Multiple myeloma typically affects elderly patients.
SUMMARY : New imaging techniques may provide more accurate estimations of BAT mass in adults.
SUMMARY OF BACKGROUND DATA : An increase in TLHIs complicated by DISH was observed.
SUMMARY OF BACKGROUND DATA : CSM is a progressive spine disease and the leading cause of spinal cord dysfunction worldwide.
SUMMARY OF BACKGROUND DATA : DISH and thoracic kyphosis are well-defined radiographical findings in spines of older individuals.
SUMMARY OF BACKGROUND DATA : Halo orthosis is a device used for providing stable fixation of instability of cervical spine injury.
SUMMARY OF BACKGROUND DATA : Lumbar instability is one of the common degenerative changes , which presents as @number@ radiologic features : anterolisthesis and retrolisthesis.
SUMMARY OF BACKGROUND DATA : Lumbar spinal stenosis is a prevalent and disabling condition in the aging population.
SUMMARY OF BACKGROUND DATA : Scheuermann disease is a form of osteochondrosis characterized by increased posterior rounding of the thoracic spine with structural vertebral deformity.
SUMMARY OF BACKGROUND DATA : The anatomical features of the EM have been mostly discussed on the basis of cadaver studies in the whole spine.
SUMMARY OF BACKGROUND DATA : The number of cervical spine procedures in the United States has risen along with associated hospital costs.
SUMMARY : On the basis of current evidence , there is no role for oral DHEA supplementation in healthy , postmenopausal women.
SUMMARY : Optimizing dietary protein intake to improve health requires a detailed consideration of topics including muscle protein anabolism , appetite control and satiety.
SUMMARY : Our findings support recent efforts to integrate collaborative care approaches into chronic disease management , with the strongest evidence for pharmacist care.
SUMMARY : Pediatricians should be familiar with the use of common cosmeceuticals used in children , especially the use of broad-spectrum sunscreen.
SUMMARY : PFDs are a significant public health issue and they negatively impact the lives of millions of adult women.
SUMMARY : Pharmacogenetic knowledge has already had considerable impact on antiretroviral prescribing.
SUMMARY : Prevention and treatment of PEW should involve individualized and integrated approaches to modulate identified risk factors and contributing comorbidities.
SUMMARY : Previous studies on the association between uric acid and bone mineral density yielded conflicting results.
SUMMARY : Recent evidence suggests positive effects of protein supplementation on muscle protein synthesis , muscle mass and muscle strength.
Summary recommendations are provided in this review.
Summary relative risks ( RRs ) were calculated using meta-analysis methods.
SUMMARY : Reports regarding the relationship between frailty , visual impairment , cataract , and cataract surgery are limited , but gradually increasing.
SUMMARY : Research in the use of low and high technology in late-life mental disorders continues to evolve in its scope and innovation.
SUMMARY : SBD remains poorly studied.
SUMMARY : Several inflammatory biomarkers appear to add to our ability to predict mortality or opportunistic disease in HIV-infected individuals.
SUMMARY : Significant evidence-based data exists confirming the positive effects of exercise in otherwise healthy populations.
Summary statistics ( means , standard deviations , proportions ) were used to describe the study sample.
SUMMARY : Still little is known about the relationship between delirium and cognitive trajectories in the elderly , and the underlying pathophysiological mechanisms.
SUMMARY : Supraventricular arrhythmias exceed ventricular arrhythmias in prevalence , as atrial fibrillation increases with the aging population.
SUMMARY : Taken altogether , these results from independent teams using multiple organisms including humans draw the lines of future directions in ageing research.
SUMMARY : Telomere length shortens with age.
SUMMARY : The aim of this study was to examine the gender-specific association between sarcopenia and bone geometry / metabolic parameters.
SUMMARY : The biochemical mechanisms by which RECQL4 and p53 affect mtDNA replication have been elucidated.
SUMMARY : The conventional paradigm of kidney disease in people with diabetes has been challenged.
SUMMARY : The future increase in elderly patients being exposed to surgery calls for improved perioperative management to prevent collaterally increased AKI.
SUMMARY : The influence of age and sex steroids on bone density and geometry of the radius was examined in two European Caucasian populations.
SUMMARY : The most important recent findings disclose that HDL is more complex than previously thought.
SUMMARY : The positive effects of protein intake on bone health may only be beneficial under conditions of adequate calcium intake.
SUMMARY : The potential of twin studies to understand ageing and dementia is only beginning to be realized.
SUMMARY : The present cross-sectional study investigated the prevalence of sarcopenia and clarified its associated factors in @number@ elderly participants of Japanese population-based cohorts.
SUMMARY : The present findings are suggestive of an almost complete lack of evidence on the addressed topic.
SUMMARY : The prevalence of sarcopenia increases with age.
SUMMARY : There are increasing data to support the role of nutrition in maintaining cognition.
SUMMARY : There is no standard treatment for olfactory loss.
SUMMARY : The scarcity of fungal endocarditis demands a high index of suspicion and knowledge of the group of at-risk patients.
SUMMARY : These advantages and disadvantages of blue light filtering IOLs have not been proven clinically and thus many questions remain.
SUMMARY : The use of antiretroviral therapies in older individuals is complex.
SUMMARY : This review article describes the demographics of ambulatory surgery in the elderly population.
SUMMARY : To date , there is no effective treatment for muscle wasting.
SUMMARY : Treatment of older patients with liver disease may require different or longer interventions.
SUMMARY : UES and cricopharyngeus function is complex and dynamic.
SUMMARY : Various factors that affect Klotho expression have been identified.
SUMMARY : VGDT is an emerging approach that shows enormous promise for stroke rehabilitation.
SUMMARY : We determined factors associated with serum sclerostin in @number@ Afro-Caribbean family members.
SUMMARY : We studied femoral geometry in relation to age and ethnicity in a cross-sectional study.
SUMMARY : With the goal to improve stem cell properties that are impaired upon aging , some strategies are highlighted.
Summated power in frequencies between @number@ and @number@ Hz was almost always < 5 µV ( @number@ ) .
SUMO2 / 3 , in contrast to SUMO1 , are predominantly involved in the cellular response to certain stresses , including heat shock.
SUMO conjugation to calpain @number@ promoted its enzymatic activity , and SUMO attachment to calpastatin mainly promoted its turnover and altered its subcellular distribution.
Sumoylation is a posttranslational modification that regulates a wide spectrum of cellular activities.
SUMOylation is a reversible posttranslational modification of specific target proteins by the attachment of a small ubiquitin-like protein.
SUMOylation substrates are numerous and diverse and modification by SUMO is involved in many biological functions , including the response to stress.
Sunburned skin , including minimal asymptomatic ultraviolet ( UV ) radiation-induced erythema , is characterized by infiltrating neutrophils.
Sunburned skin is a leading risk factor for melanoma and non-melanoma cancers.
Sun exposure among infants and pre-school children is largely dependent on the discretion of adult care providers.
Sun-induced reduction of SC hydration is more evident on the dorsal hand of aged females than that of males ( P < 0.001 ) .
Sunitinib is an antiangiogenic therapy given as a first-line treatment for renal cell carcinoma ( RCC ) .
Sunlight includes infrared light photons , visible light and ultraviolet light ( UVL ) photons.
Sunlight is indispensable for life.
Sunlight , specifically UVB and UVA , triggers various types of DNA damage.
Sun-protected skin on the lower back of geriatric human volunteers was wounded by dermabrasion and the skin was allowed to heal for three months.
Sun protective habits of mothers may predict the level of sun exposure in children.
Sunscreen pre-application abrogated or significantly reduced these effects , as underlined by unsupervised clustering analysis.
Sunscreens absorb only a portion of UV radiation and often are not photostable.
Sunscreens also prevent photoimmunosuppression and signs of photoaging.
Sunscreens are an important aspect of photoprotection.
Sunscreens are commonly used as protection against sun damage.
Sunscreens are known to protect against radicals generated by UV radiation ; however , no data exist for those generated by IR radiation.
Sunscreens are very valuable , but they have limitations.
Supartz® , compared with the phosphate-buffered saline control , significantly reduced the total Lesquésne Index score in the post-injection period.
Supartz® was well tolerated in patients with osteoarthritis of the knee.
SuperAgers also displayed a patch of ACC where cortical thickness was higher than in 50- to 60-year-old younger cognitively healthy adults.
SuperAgers were also found to have a lower frequency of the ɛ4 allele of apolipoprotein E than the general population.
Supercentenarians ( @number@ years or older ) are the world's oldest people.
Superficial layers I to III of the human cerebral cortex are more vulnerable toward Aβ peptides than deep layers V to VI in aging.
Superficial lipodystrophy defines thisfacial region in the cadaver specimens.
Superficial temporal and central forehead compartments were delimited , analyzing respective volumes and dimensions by group.
Super-imposable three-dimensional ( 3D ) photographs were taken at baseline and @number@ weeks post-second treatment.
Superimposing mild COPD on the normal aging effects had greater sensory consequences in women because of their naturally reduced ventilatory reserve.
Superior quadrant RNFL thickness was greatest in ART-naïve participants relative to the HIV-uninfected group ( p-trend = @number@ ) .
Superior vestibular ganglion cells were more negatively correlated with age than inferior ganglion cells.
Supernatants from human fractured tibial bone fragments promote osteogenesis and migration of muscle-derived stromal cells ( MDSC ) in vitro.
Supernormals had less amyloid deposition than other groups.
Superoxide and hydrogen peroxide ( H RATIONALE : The thoracic aortic wall can degenerate over time with catastrophic consequences.
Superoxide and nitric oxide are generated by skeletal muscle , and these species are increased by contractile activity.
Superoxide anion and free radicals among KYN derivatives trigger phospholipase A2-arachidonic acid cascade associated with AAMPD.
Superoxide dismutase activity in response to acute exercise was significantly higher in young compared to older adults ( P < @number@ ) .
Superoxide dismutase ( SOD ) activity and plasma levels of total glutathione and protein carbonyls were determined.
Superoxide dismutase was higher at rest and at the recovery for the physically active subjects compared with sedentary subjects ( p < @number@ ) .
Superoxide production improved @number@ months following fracture to the level seen in controls.
Supervisors thus exercise discretion , sometimes reclassifying gift exchanges as punishable thefts.
Supplemental materials are available for this article.
Supplemental n-3 PUFA was also positively associated with forced vital capacity ( b = 0·091 , SE = 0·045 , P = 0·045 ) .
Supplemental Security Income ( SSI ) was the most commonly utilized social service among HIV-infected.
Supplemental vitamin D is likely necessary to avoid deficiency , especially in winter months.
Supplemental vitamin E intake was non-significantly associated with ARC risk ( relative risk = 0·92 ; @percent@ CI 0·78 , 1·07 ) .
Supplementary ( 0-2 years ) weight and length measures ( needed for growth curve modelling ) were drawn from subjects ' child health records.
Supplementary information : Supplementary data are available at Bioinformatics online.
Supplementary information : Supplementary data are available at Bioinformatics online.
Supplementation of Cr to the parenteral nutrition ( PN ) solution corrected these abnormalities.
Supplementation of either diet with AJC dramatically improved the performance of both genotypes.
Supplementation of N-ethylmaleimide in the cell lysis buffer was critical for the apparent bands of oxidized and reduced PTEN.
Supplementation of RJ in the diet has been shown to increase spatial memory in rodents.
Supplementation protects against oxidative damage although it enhances nitrative damage in young athletes.
Supplementation was well tolerated.
Supplementation with FPP did not modify alpha-tocopherol depletion but significantly improved redox balance parameters.
Supplementation with FPP significantly , although partially , downregulated TNF-alpha production from monocytes.
Supplementation with the vitamins B12 and folic acid could contribute to reduced chromosomal damage in institutionalized elderly.
Supplementation with Vitamin E can restore the balance and protect against the deteriorating effects of oxidative stress , progression of degenerative diseases , and aging.
Supplementation with vitamin K1 and K2 may reduce the risk of fractures , but the trials that examined fractures as an outcome have methodological limitations.
Supplementing standard methods with alternative methods reduced these error rates to @percent@ and @percent@ respectively.
Supplementing with creatine , a high-energy compound found in red meat and seafood , during resistance training has a beneficial effect on aging muscle.
Supplements such as α-lipoic acid may have antiaging effects by positively affecting oxidative stress , cognitive function , and cardiovascular function.
Supplements were removed approximately @number@ hour before meals were served and weighed waste ( g ) was obtained.
Supplement use increased the prevalence of polypharmacy and resulted in potential supplement-drug interactions.
Supplement users followed in general a healthier lifestyle than non-users.
Supplement users had increased prevalence of polypharmacy compared to non-users ( @percent@ vs. @percent@ , p < 0.001 ) .
Supplement users tend to be non-Hispanic white , have higher family incomes , report more physical activity , and have health insurance.
Supplement use was almost twice as prevalent in the ID group but substantially less diverse with only @number@ types of supplements reported.
Supported decision-making is increasingly being promoted as an alternative to guardianship for persons aging with intellectual disabilities.
Support for associations between these biomarkers and episodic memory and SCC were more limited.
Support for families to take care of elderly relatives would appear to be essential for an effective nursing and social care system.
Support for older adults to maintain socially engaged lives and to access the internet should help promote the maintenance of functional literacy skills during ageing.
Support for the development of neurotherapies must continue from the bench to their ultimate place at the bedside.
Support for this hypothesis has come from cross sectional , longitudinal , and intervention studies.
Support for this prediction has been obtained from various sources.
Support from adult children to ageing parents may be of importance for parental health and longevity.
Support groups , counseling , and psychotropic medications were used in similar proportions.
Supporting cells may play a role in the clearance of excess neurotransmitters after their release from taste receptor cells.
Supporting experimental approaches as well as physiologically based pharmacokinetic modeling are also discussed together with their limitations and challenges.
Supporting older people with pain to be active requires sensitivity to the function of activity restriction , especially as a means of preventing deterioration.
Supporting people living with dementia in maintaining selfhood , relationships , and well-being requires seeing beyond the common negative focus on disability.
Supporting the in vitro data , cilostazol was found to significantly increase ( @number@ ) H-tracer levels in both plasma and feces.
Supporting the problematic activities need not involve a robotic solution.
Supportive analyses were also performed classifying as responders patients with a percentage of affirmative answers of at least @percent@ or > 75% of time.
Support operated in three key domains : ( @number@ ) informational support , ( @number@ ) clinical support , and ( @number@ ) personal support.
Support provided through home care services may be useful in attaining a more efficient and higher quality care for CKD patients.
Support systems , however , are not infallible.
Support to assist caregivers in this often stressful and demanding role is critical to sustaining the caregivers ' health and ability to provide care.
Support vector machines ( SVM ) were used to discriminate PD versus AD versus controls.
Support was insufficient when their expectations of support were not met ; unmet support expectations led to an overall negative TKA experience.
Supposedly leptin modulates osteocalcin bioactivity , which in turn stimulates insulin and adiponectin secretion , and β-cell proliferation.
Suppression effort increased linearly with age ( though perceived difficulty did not ) .
Suppression of deacetylase survival factor sirtuin @number@ ( SIRT1 ) , a key host defense , is a central feature of AD.
Suppression of irrelevant information , unlike enhancement of relevant information , has been shown to be deficient in aging.
Suppression of Jmjd3 in N9 microglia inhibited M2 polarization and simultaneously exaggerated M1 microglial inflammatory responses , which led to extensive neuron death in vitro.
Suppressor of cytokine signaling ( SOCS ) proteins are the most important regulators of this cytokine signaling pathway.
Suprabasal cells expressing LBR showed altered DNA distribution , suggesting the induction of gene expression changes.
Supramaximal single and doublet electrical stimulation was used to assess the contractile properties of the quadriceps.
Supramolecular 3D entities are highly attractive materials for biomedical application.
Suprapatellar bursal fluid < 3 mm was detected in 9 / 60 ( @percent@ ) knees.
Supraperiosteal placement is performed with a sharp needle or a non-traumatic cannula.
Supratentorial tumor location , older age , and treatment prior to @number@ were poor prognostic factors.
Sural nerve sensory nerve conduction velocity in the lower extremities were low relative to controls.
Surface and subsurface reflection components were extracted by means of an image-processing technique.
Surface-based analysis of cortical T1 values was performed with the FreeSurfer toolbox.
Surface-based analysis was applied to assess cortical thickness in the whole brain.
Surface-based and volume-based analyses were performed for @number@ cortical and subcortical regions of interest per hemisphere.
Surface-based smoothing increases reliability of cortical thickness maps , while it decreases reliability of cortical surface area and volume.
Surface electromyography ( EMG ) electrodes were placed at midline underlying the submental muscle group.
Surface electromyography signals were sampled from the left soleus , medial gastrocnemius and tibialis anterior.
Surface electromyography was performed to evaluate masticatory muscles activity.
Surface electromyography was used to evaluate motor unit action potential for each muscle in each of six eyebrow movements.
Surface muscle activity of @number@ leg and trunk muscles was analyzed to identify sets of @number@ muscle modes ( M-modes ) .
Surface roughness values of G Aenial Posterior and Filtek Ultimate Universal Restorative increased significantly after surface sealant application.
Surface roughness was determined before and after tooth brushing.
Surgeons are therefore emphasizing soft tissue augmentation to achieve a natural , rejuvenated appearance in patients.
Surgeons can adopt either approach with confidence depending on their preference if they are familiar with that approach.
Surgeons ' disagreement about ideal treatment for proximal humerus fractures ( PHFs ) may reflect a difference in training.
Surgeons need to be more selective with advancing age regarding who will benefit from the surgical intervention.
Surgeons should be aware of preexisting alterations in traumatized spines and the impact on therapeutic decisions.
Surgeons should consider parathyroidectomy in patients with primary hyperparathyroidism regardless of age.
Surgeons should take care to minimize the likelihood of intraoperative blood transfusion in elderly patients.
Surgeons will be able to select several options of the treatment for CHF by understanding the advantages and disadvantages of those surgical treatments.
Surgeries requiring prolonged neck hyperextension put patients with cervical spondylosis at risk for SCI.
Surgery alone was performed in @number@ % , and combined with antifungal therapy in @number@ %.
Surgery and postoperative care were performed according to the surgeons ' usual routines.
Surgery and postoperative care were performed according to the surgeons ' usual routines.
Surgery can also be beneficial in diagnosis and treatment of IPA.
Surgery caused marked inflammation with high peak values of CRP and SAA on the second day after the operation.
Surgery , cholecystostomy , and ERCP presented harms in 21-25 %.
Surgery for PFDs is common as @percent@ of women undergo stress urinary incontinence or POP surgery over their lifetime.
Surgery had a significant impact on outcomes ( p < @number@ ) .
Surgery , if possible , is the treatment of choice for acromegaly in the elderly.
Surgery involving elderly patients is becoming increasingly common due to the rapid aging of societies all over the world.
Surgery is frequently needed but the clinical outcome is often poor due to the decreased natural healing capacity of the elderly.
Surgery is seldom needed.
Surgery is usually the treatment of choice , but conservative treatment may be a good alternative in some situations.
Surgery requires highly-trained individuals with expensive operating facilities.
Surgery was needed in @percent@ of patients , and global mortality rate was @percent@.
Surgery was successful when a one-third reduction of baseline IOP was obtained at the last follow-up.
Surgery , when considered from a technical point of view , does not differ significantly with patient age.
Surgery with dural plasty and laminoplasty resulted in decompression of the cervical cord with clinical improvement , revealing marked thickening of the dura mater.
Surgical aesthetic facial rejuvenation has become increasingly popular , more accessible , and has lost much of the stigma that it once carried.
Surgical and nonsurgical options are reviewed as well as benefits and side effects.
Surgical execution necessitates experience in the indications for each type of implant for various types of defects.
Surgical incisions cause further disruption of the microvasculature of aged skin.
Surgical indications and approaches , including direct , coronal , mid-forehead , endoscopic , and trans-blepharoplasty , are reviewed.
Surgical intervention for the spine and lower extremities is also indicated if conservative management proves ineffective in subjects with progressive walking disability.
Surgical intervention is the treatment of choice , but its outcomes may not be satisfactory because of recurrence and physical infirmity associated with aging.
Surgical intervention is typically required.
Surgical interventions for esthetic purposes are usually associated with higher complication rates and longer recovery times when compared to less invasive treatments.
Surgical management has also been subject of numerous technical and strategic developments.
Surgical margin was R0 in @number@ patients ( @percent@ ) .
Surgical morbidity was classified according to the Chassagne grading system.
Surgical procedures in elderly patients are associated with a higher risk of complications.
Surgical procedures that proved to be a risk factor for acute exacerbation should be chosen cautiously for these high-risk patients.
Surgical repair of the damaged labro-acetabular complex should satisfy two goals.
Surgical replacement of the aortic valve is an effective treatment modality in patients with degenerative and calcific aortic stenosis.
Surgical replacement remains the treatment of choice for this disease.
Surgical resection of nonobstructive degenerate lesions may merely remove evidence of the disorder while the OA and associated symptoms proceed.
Surgical resection with a lobectomy is the standard treatment for stage I non-small cell lung cancer.
Surgical site infections were seen in @percent@ of patients , all of whom had had arthroplasty.
Surgical stress parameters were collected preoperatively , @number@ @number@ and @number@ days after surgery.
Surgical treatment is the only means of treating cataract ; this approach , however , has limitations and complications.
Surgical treatment may be considered in such cases with well-circumscribed lesions.
Surgical treatment of proximal femoral fracture is one of the most common surgeries for orthopaedic surgeon.
Surgical treatment was applied in @percent@ of patients ; median hospital stay was @number@ days.
Surgical treatment was used at a higher rate in the younger cohort ( p = @number@ ) .
Surprisingly , acetylated proteins were largely excluded from compact aggregates.
Surprisingly , after joint-treatment with the @number@ kinds of stimulators together , synergistic effects on follicular development were observed.
Surprisingly , alanine substitutions in the motif failed to alter C99 dimerization in detergent soluble state.
Surprisingly , among HIV-infected women , total body fat , not lean mass , was associated with frailty in multivariate analysis.
Surprisingly , a narrow bandwidth in blue light generated the greatest phototoxic risk to retinal pigment epithelium cells.
Surprisingly and in contrast to what has been recently reported for ubiquitin-induced pexophagy and xenophagy , p62 appears to be dispensable for mitophagy.
Surprisingly , ASncmtRNA-2 is not upregulated in two different EC SIPS scenarios , treated with H2O2 and UV.
Surprisingly , bone morphogenetic protein receptor 1a extracellular domain ( BMPR1a-ECD ) exhibited an anti-wrinkle effect which was 6-fold greater than that of retinoic acid.
Surprisingly , changes in heteroplasmy were not uniform with some sites demonstrating a loss of variation ( increased homoplasmy ) with aging.
Surprisingly , CMV status did not have a significant impact on longitudinal trends in CD8 + CD38 + HLA-DR + %.
Surprisingly , coffee is associated with neutral to reduced risks for both atrial and ventricular arrhythmias.
Surprisingly , computed tomography angiography completed based on the recommendation of neurology department identified three saccular CAs.
Surprisingly , cytomegalovirus infection seems to be associated with these T cell alterations.
Surprisingly , deacetylase sirtuin @number@ ( SirT1 ) , one of the top predicted targets , was positively regulated by miR-34a during SMC differentiation.
Surprisingly , distance metrics that incorporate the biases of somatic hypermutation do not outperform simple Hamming distance.
Surprisingly , endurance running only had modest effects on cardiovascular function compared to lean healthy controls.
Surprisingly , expression of the self-renewal-associated gene PRDM14 or the developmental processes-regulating genes WNT3A and GSC are restricted to ESCs.
Surprisingly , for both older adults and AD patients , results of Experiment @number@ revealed a similar OD effect across all study-test cycles.
Surprisingly , G → T mutations , considered the hallmark of oxidative damage to DNA , do not significantly increase with age.
Surprisingly , he wrote the poem as a young man.
Surprisingly , highly educated older adults showed the reversed age pattern-they looked more toward factual cues than did young adults.
Surprisingly , high-quality care increased the risk of death while poor-quality care decreased the risk.
Surprisingly , however , epidemiologic data from several recent independent cohort studies suggest that there may be an inverse association between these diseases.
Surprisingly , however , instead of decreasing , the nSMase activity and ceramide increased in the OTC-fed mice irrespective of their age.
Surprisingly , however , little is known about whether and how chronic stress contributes to microglia-mediated neuroinflammation that may underlie cognitive impairments in AD.
Surprisingly , in vascular smooth muscle cell ( VSMC ) activation of DNA damage response pathway downstream of ataxia-telangiectasia mutated ( ATM ) was observed.
Surprisingly , in young mice , Sod2 deficiency accelerated wound closure , increasing epidermal differentiation and reepithelialization , despite the reduced proliferation.
Surprisingly , less social support was associated with stronger perceived control.
Surprisingly , little agreement exists on the association of cortisol and cognitive impairment.
Surprisingly little information has been published regarding the normal chimpanzee immune system , and most extant studies have been based on small numbers of animals.
Surprisingly , long-term intake of large amounts of fish oil shortened the lifespan of these mice.
Surprisingly , metformin did not affect levels of serum cholesterol , triglycerides , glucose and insulin.
Surprisingly , mouse lines with genetic impairment of anti-oxidative capacity generally did not show enhanced cognitive ageing but rather an increased sensitivity to oxidative challenge.
Surprisingly , no gender differences are observed.
Surprisingly , OA exhibited more learning than YA in the two vocal response conditions.
Surprisingly , observational studies are not consistent with different effects in men and women.
Surprisingly , only minimal differences were observed between lower and higher microbeam energy settings.
Surprisingly , our results suggest that the pelvis and L4 vertebra increase in width after skeletal maturity and cessation of longitudinal growth.
Surprisingly , performance for discriminating motion away from horizontal was strongly decreased.
Surprisingly , relatively few tests of judgment have been developed specifically for older adults a population particularly vulnerable to executive and functional declines.
Surprisingly , solid historical data reveal the epidemic is a creature of the last century.
Surprisingly , specific DNA regions show directional epigenetic changes in aged individuals suggesting the importance of these events for the aging process.
Surprisingly , the AIMP3 transgenic mouse exhibited a progeroid phenotype , and the cells that overexpressed AIMP3 showed accelerated senescence and defects in nuclear morphology.
Surprisingly the decrease in FWS of crows ' feet at rest was more pronounced.
Surprisingly , the effect of EX-527 on SIRT1-DBC1 binding is independent of DBC1 acetylation.
Surprisingly , the excess of fatty mass seems not to be related to atherosclerotic burden in very elderly individuals.
Surprisingly , the mean mRNA levels of TNF-α and IL-1β in leptomeningeal cells after treatment with the conditioned medium from P.g.
Surprisingly , the minor variant , V92M , was associated with increased risk of photoaging ( @number@ ( @number@ @date@ ) ) .
Surprisingly , the most frequent patterns were consistent with replication traverse of an ICL , without lesion repair.
Surprisingly , the opposite is true in an inter-species context.
Surprisingly , there are only three published studies that have addressed the question of whether meditation diminishes age-related brain degeneration.
Surprisingly , the same mice showed a threefold increase in total endogenous murine Tau in CSF at the stages when Aβ pathology became prominent.
Surprisingly , these studies have revealed that the homozygous deletion of CDKN2A / 2B is a major hallmark of iron-induced carcinogenesis.
Surprisingly , these two groups of nucleoporins differ dramatically in their turnover rates.
Surprisingly , the technique used for this classification permits a uniqueness proof of the solution of the ODE model in a non-Lipschitz case.
Surprisingly , the unfavorable effects of cardiovascular disease on ESRD and of diabetes on survival significantly decreased with increasing age.
Surprisingly , the variant was observed seven times in the ExAC database , presumably in individuals without BOS.
Surprisingly , this loss of resistance is not a result of intrinsically defective T cell responses.
Surprisingly , this regulatory function of VEGF is not based on paracrine signaling involving cell surface receptor activation.
Surprisingly , this topic has received little attention in the rheumatology community.
Surprisingly , two months or more of exercise intervention appeared to be ineffective to promote cognitive performance compared to shorter durations.
Surprisingly , variations in the skin hue show a total absence of correlation with the consumer grading.
Surprisingly , we also found that CSPalpha expression is upregulated in cerebellum in Alzheimer's disease.
Surprisingly , we found HF2-BE2 could also deaminate C that was proximal to the gRNA-binding region.
Surprisingly , we found that the expression of autophagy-related proteins was not decreased in the tissues of patients with OA.
Surprisingly , we found widespread sIBM-specific changes in the RNA metabolism pathways themselves.
Surprisingly , when expressed in relation to baseline pupil size , no significant age-related differences were observed in pupil constriction.
Surprisingly , wild-type γd-crystallin promoted W42Q polymerization in a catalytic manner , even at mutant concentrations too low for homogeneous nucleation to occur.
Surprisingly , within @number@ days @percent@ of the primary amino groups are lost and mostly converted into amides.
Surrogates commonly face a broad range of decisions in the intensive care unit and the hospital ward setting.
Surrogates had knowledge if they correctly predicted all @number@ responses.
Surrogates of whole-brain white matter ( WM ) networks reconstructed using diffusion tensor imaging ( DTI ) are novel markers of structural brain connectivity.
Surrogates randomized to the intervention had contact with the FN on @percent@ or more of eligible patient days.
Surrogates were asked whether they believed the older person had completed these activities.
Surveillance for incident events commenced at examination @number@ and continued for @number@ years.
Surveillance mechanisms acting at the molecular , organellar , and cellular level monitor mitochondrial integrity and ensure the maintenance of mitochondrial proteostasis.
Survey-adjusted data were analyzed descriptively.
Survey data found that workers felt more competent and self-confident about their abilities to work with residents.
Survey data was collected via interview from residents of a continuing care retirement community.
Survey data were collected from @number@ residents in San Diego County.
Survey data were collected from @number@ retirees across three time points.
Survey domains were drawn from constructs of behavioural change models.
Survey findings reveal a sample of highly engaged older African Americans in reasonable health who perceive their neighborhoods favorably.
Survey format consisted of yes and no responses , Likert scale and open / closed-ended responses.
Survey items on physical activity were combined to produce a measure of moderate or vigorous physical activity for each wave.
Survey measures included baseline emotional support , fatalism , and acceptance and emotional well-being @number@ months later.
Survey results were then used to identify patterns or trends that existed in the data.
Surveys and clinic-based research reports on headache disorders in elderly populations are extremely limited in number.
Surveys were mailed , given during follow-up clinic , or answered during telephone contact.
Surveys were used for depression , fatigue , loneliness , self-reported activity level , and sexual function.
Survival after diagnosis is about 12-14 months.
Survival among elderly patients is significantly less than among younger patients.
Survival analyses at 1- , 3- and 5-year intervals were performed using the Kaplan-Meier method.
Survival analyses were conducted using Cox regression models.
Survival analyses were performed using intention-to-treat analysis by Log-rank tests and Cox regression adjusted for confounders.
Survival analysis determined whether or not baseline rCBF predicted later development of use disorders.
Survival analysis examined the effect of baseline pulse pressure on progression to dementia.
Survival analysis showed an increased risk of mortality in each frailty category using either definition , ( log-rank p < 0.001 ) .
Survival analysis showed that non-denture wearers and removable-denture wearers had lower follow-up 4-year survival.
Survival analysis was performed to determine the association between reservoir-wave parameters and cardiovascular events.
Survival analysis was performed using a Kaplan-Meier curve and a stepwise Cox regression analysis.
Survival analysis was used to assess associations between incident advanced disease and vitamin D intake.
Survival at @number@ months was unaffected ( adjusted hazard ratio [ aHR ] , @number@ @percent@ CI , @number@.54-1.08 ; P = @number@ ) .
Survival curves across RDW quartiles were statistically different according to the log-rank test ( p = @number@ ) .
Survival curves were estimated using the Kaplan-Meier curve.
Survival data was available in @number@ out of @number@ patients.
Survival data were collected @number@ years after enrollment.
Survival did not equal that seen in clinical trials for either country , but strong improvement in survival was seen between @number@ and @number@
Survival during hospitalization , at 1- and 5-year follow-ups was the outcome of interest evaluated with Cox proportional hazard models.
Survival estimates increased for a minority of haematologic malignancies between 2003-2007 and 2008-2012.
Survival for patients with acute myeloblastic leukemia ( AML ) has increased during the past two decades.
Survival increased between @number@ and @number@ by @percent@ points in Germany and @percent@ points in the US.
Survival increased by @number@ years ( @number@ vs. @number@ years ) .
Survival increased slightly in southern Europe , more in the UK , and conspicuously in northern , central , and eastern Europe.
Survival in eastern Europe was generally low and below the European mean , particularly for cancers with good or intermediate prognosis.
Survival is longer after adjuvant radiotherapy , either normofractionated over 6-weeks course or hypofractionated over 3-weeks course , for patients with good clinical status.
Survival is significantly longer in patients who necessitate exenteration greater than @number@ years out from initial treatment.
Survival = months.
Survival of C9 + patients with ALS and C9 + patients with ALS-FTD declined over the 12- and 18-month follow-up.
Survival of HL patients in the US was lower than in Germany overall , but was comparable in older patients and in women.
Survival of @number@ g / kg mice was significantly less than that of the vehicle controls ; the cause of the deaths was uncertain.
Survival of premature infants born at increasingly earlier stages of gestation has made the prevention of lung injury increasingly challenging.
Survival of study participants was checked annually over the period of @number@ years.
Survival of the participants was documented during a period of up to @number@ years.
Survival of TRIAP1- and PRELI-deficient cells is conferred by an excess of exogenously provided phosphatidylglycerol.
Survival , primary and secondary patency , and freedom from restenosis were comparable between patients who reported symptomatic improvement and those who did not.
Survival rates have continued to improve while treatment modifications to decrease late effects are studied across all populations.
Survival status was followed up at @number@ months.
Survival substantially increased over time in all European regions.
Survival time was significantly shorter in the FTLD-ALS and ALS-FTLD groups than in the FTLD without ALS group ( P < @number@ ) .
Survival time within a @number@ years post-discharge follow up period was used as the outcome.
Survival to hospital discharge was higher for sports-associated SCA ( @percent@ versus @percent@ ; P = 0.04 ) .
Survival usually decreased with age , although to different degrees depending on region and cancer type.
Survival was followed up to @number@ months.
Survival was highest for northern , central , and southern Europe.
Survival was modeled on the basis of published data from the Italian cancer registries.
Survival was significantly better in patients with lower ASA scores ( P = 0.005 ) .
Survival was similar between patients with childhood- and adult-onset craniopharyngioma.
Survival with and some risk factors for diabetes have improved in developed countries , but global diabetes mortality has increased by @number@ % since @number@
Survival = years.
Survivin expression was increased in polyploid / senescent cells as analyzed by Western blotting.
Surviving RPE cells from explants cultured for @number@ days were harvested to compare bestrophin and RPE65 mRNA expression.
Survivors also had significantly shorter LTL compared with controls ( median , @number@ vs @number@ base pairs ; P = @number@ ) .
Survivorship was determined by the National Death Registry until the end of @number@
Survivors of a TIA or stroke have an increased risk of another stroke , which is a major source of increased mortality and morbidity.
Survivors were divided into recovery and nonrecovery groups according to their RF @number@ days post-AKI.
Survivors who received cranial irradiation had shorter LTL compared with those who had not ( P = @number@ ) .
Susceptibility testing of A. fumigatus isolates was performed by Etest , followed by EUCAST broth microdilution testing if elevated MICs were recorded.
Susceptibility to environmental stressors has been described for fetal and early childhood development.
Susceptibility to eryptosis is enhanced in aged erythrocytes and stimulated by NFκB-inhibitors Bay 11-7082 and parthenolide.
Susceptibility was positively associated with age and negatively associated with income , cognition , psychological well-being , social support , and literacy.
Suspected aberrations in the structure and function of the connective tissue , muscles , and nerves of the pelvic floor are still under investigation.
Suspending treatment as part of a drug holiday may reduce the risk of adverse effects , but may also lead to reduced BMD.
Sustainability is , therefore , an intergenerational phenomenon , and protecting resources today leaves a positive legacy and enhances quality of life for future generations.
Sustained activation of the NF-κB pathway by TNFα has been reported to involve upregulation of IKKβ kinase activity.
Sustained improvements at @number@ months compared with baseline indicate that efficacy could be maintained long term.
Sustained N1ICD activity induced EC senescence , expression of chemokines and the adhesion molecule VCAM1.
Sustained oxygen therapy use increased from @percent@ in @number@ peaked in @number@ to @percent@ and declined to @percent@ in @number@
Sustained proliferative signaling and de-regulated cellular bioenergetics are two of the chief hallmarks of cancer.
Sustained responses at the onset of vowel periodicity were prolonged in latency and smaller in amplitude as age increased.
Sustained responses were observed in @number@ patients , after a median follow-up duration @number@ months ( interquartile range 9-37 ) .
Sustained stress or irreparable damage trigger p53's killer functions to permanently eliminate genetically-altered cells as a potential source of cancer.
Sustained technical assistance with using EHRs for performance improvement and care coordination is also needed.
Sustained voice activation is a useful examination maneuver that may elicit or amplify head tremor in ET.
Sustaining musical and interpersonal connectedness would help value who the person is and maintain the quality of their life.
Suture threads are a minimally invasive surgical technique for facial rejuvenation.
SVBP increased the solubility of VASH1 protein in detergent solution and inhibited the ubiquitylation of VASH1 protein.
SVD can present as a stroke or cognitive decline , or can have few or no symptoms.
SVD frequently coexists with neurodegenerative disease , and can exacerbate cognitive deficits , physical disabilities , and other symptoms of neurodegeneration.
SVD markers include white matter hyperintensities ( WMHs ) using the modified Fazekas scale , lacunes and microbleeds.
SveDem is a national quality registry in Sweden , which was established in @number@ to evaluate and improve dementia healthcare.
SVI was also strongly correlated with scan quality ( R ( @number@ ) = 0.77 ) .
SVM analyses were highly accurate at distinguishing PD versus AD versus controls.
SV patients showed also a strongly left-lateralized loss of hubs , and reduced nodal degree in the inferior and ventral temporal regions and occipital cortices.
SVR was defined as undetectable serum HCV RNA by real-time polymerase chain reaction ( PCR ) @number@ weeks after IFN discontinuation.
SV was calculated by Doppler echocardiography.
Swallowing disorders are common in the elderly , and aging is a factor that affects swallowing function.
Swallowing disorders are common in the elderly and may become life-threatening when they cause aspiration , inhalation pneumonia , malnutrition or dehydration.
Swallowing is complex neuromuscular activity consisting essentially of @number@ phases : oral , pharyngeal , and esophageal.
SWA ( @number@ ) and TWA ( @number@ ) declined significantly ( P < @number@ ) across ages @number@ to @number@
Sway path traveled and area covered by the center of foot pressure were recorded , low values indicating efficient balance.
Sway velocity and mediolateral sway range were recorded.
Sway velocity was used to measure SB standing on a platform and foam with eyes open and closed.
SWB was assessed using the WHO-5 well-being index ( score range : @number@ to @number@ ) .
SWB was dichotomized into \ "low \ " ( score ≤ @number@ ) and \ "high \ " ( score > @number@ ) SWB.
Sweden and the United States have much to learn from each other in terms of appropriately educating and training those who support our older people.
Sweden was one of the first countries to experience rapid population aging.
SWE may be valuable in detecting aging tendons before visible abnormalities are observed on B-mode ultrasonography.
Swimming exercise and caffeine supplementation increased the ratio of reduced glutathione / oxidized glutathione in the rat liver and gastrocnemius muscle.
Swimming may also result in improved balance function under few complicated balance conditions.
Swing toe trajectory has been investigated due to its association with tripping-induced falls.
Switched and IgM memory B cells execute different and noninterchangeable functions.
Switching between tasks was based on feedback-based transition cueing which places particularly high demands on mechanisms for cognitive control.
Switching rates were highest for patients taking Alendronate @number@ or Strontium Ranelate @number@ and lower for patients taking Ibandronate @number@ or Risedronate @number@
Switching the energy source from glucose to galactose caused uncoupling of mitochondria with increased proton leak in SOD1 ( I113T ) fibroblasts.
Switching to in-person interviews was not associated with measures of participant function or cognition.
Switch task performance was not associated with adaptation in either age group.
SWM was assessed via a combination of probabilistic tractography and tract-based spatial statistics ( TBSS ) .
Symmetric auditory cues at altered cadences have been used to improve walking speed or step length.
Sympathetic nerves may be involved in vasospasm.
Symptomatic androgen deficiency is common in patients taking opioid analgesics , as these drugs potently suppress the axis.
Symptomatic depression was identified a score of @number@ or higher on the 10-item Center for Epidemiologic Studies-Depression Scale.
Symptomatic improvement on the first post-operative visit was evaluated , with bilateral treatments counted separately.
Symptomatic individuals who have no contraindications to TST should be offered treatment.
Symptomatic patients frequently exhibited multiple and frontal foci , and a large number of idiopathic patients had central , temporal , and occipital foci.
Symptomatic patients require surgery ( class I , level of evidence B ) .
Symptomatic patients were significantly younger than asymptomatic ( P = @number@ ) .
Symptomatic tendon tears are one of the most important causes of pain and joint dysfunction.
Symptom duration , ACPA , SJC and CRP did not mediate the association of age with joint damage severity.
Symptom recognition by physicians treating other acute conditions was a portal to dementia services for others.
Symptoms according to the Aging Males ' Symptoms scale remained unchanged.
Symptoms and pain-related disability in TMD cases are also described.
Symptoms appear generally during early childhood and adolescence.
Symptoms are also not as reliable an indication of disease severity in older patients.
Symptoms are often similar to those of overactive bladder and the history in older women should include those of hesitancy and poor flow.
Symptoms as sleep problems , joint and muscular discomfort , heart discomfort and physical and mental exhaustion increased drastically with advancing age.
Symptom severity and level of social adjustment were measured with the Autism Diagnostic Observation Schedule and the Social Functioning Scale.
Symptom severity did not differ significantly between groups.
Symptom severity was recorded via self-reported daily Wisconsin Upper Respiratory Tract Infection Score @number@
Symptoms form a central component of illness burden , and distress.
Symptoms in persons with PART usually range from normal to amnestic cognitive changes , with only a minority exhibiting profound impairment.
Symptoms in the control eye remained unchanged.
Symptoms of androgen deficiency should be corroborated with testosterone level to establish a multidisciplinary approach for management of hypogonadism.
Symptoms of BPE may vary between the patients.
Symptoms of depression and GAD were not associated with A1C levels.
Symptoms of memory loss are caused by a range of cognitive abilities or a general cognitive decline , and not just memory.
Symptoms of sexual dysfunction ranged between @percent@ ( low sexual desire ) and @percent@ ( infrequent morning erections ) of the participants.
Symptoms of these changes can be observed starting between the ages of 40-50 years with a slow progression that increases after @number@ years of age.
Symptom-specific testosterone thresholds could not be defined.
Symptoms rated ≥4 points on the Likert scale were defined as significant.
Symptoms related to ( COPD ) are also prevalent symptoms with diverse etiologies - not limited to pulmonary obstruction.
Symptoms related to hemorrheological activation ( including itching , nocturnal cramps ) progress in parallel with increasing signs.
Symptoms were often bilateral.
Synapse formation is defective in Top3β mutant flies and mice , as well as in FMRP mutant flies and mice.
Synapses are functionally distinct neuronal compartments that are critical for brain function , with synaptic dysfunction being an early pathological feature in aging and disease.
Synapses are the building blocks of neuronal networks.
Synapses may represent a key nidus for dementia including Alzheimer's disease ( AD ) pathogenesis.
Synapses , the loci of communication between neurons , are characterized by signature protein combinations arrayed at tightly apposed pre- and post-synaptic sites.
Synaptic damage is a critical hallmark of Alzheimer's disease , and the best correlate with cognitive impairment ante mortem.
Synaptic dysfunction is a well-documented manifestation in animal models of Alzheimer's disease pathology.
Synaptic functioning may be a useful early marker of cognitive aging and possibly a target for future brain aging interventions.
Synaptic impairment rather than neuronal loss may be the leading cause of cognitive dysfunction in brain aging.
Synaptic integrity is morphologically maintained by the precise regulation of actin assembly.
Synaptic loss is one of the hallmarks of AD and associated with cognitive impairment.
Synaptic numbers correlated highly with Mini Mental State Examination scores and a test of category verbal fluency.
Synaptic pathology and mitochondrial oxidative damage are early events in disease process.
Synchondroses at the AAA closed after @number@ years ( range @date@ years ) .
Synchronization likelihood , an index based on the theory of nonlinear dynamical systems , was used to measure functional connectivity.
Synchronization Likelihood , an index based on the theory of nonlinear dynamical systems , was used to measure functional connectivity.
Synchronizing dietary guidelines for these @number@ common diseases may provide a simplified public health message.
Synchrony between the superior thorax and abdominal motion was calculated ( phase angle ) .
Syncope or presyncopal symptoms occurred in @number@ persons , @number@ athletes and @number@ controls ( p = @number@ ) .
Syndecan-1 ( SDC1 / CD138 ) is one of the main cell surface proteoglycans and is involved in crucial biological processes.
Synergistic and antagonistic dependences in geriatric disease risks were observed among US elderly confirming known and detecting new associations of wide spectrum of age-associated diseases.
Synergy was demonstrated when IB-367 was combined with colistin or imipenem.
Synonyms : 2-Methyl-6-methylene-2 , 7-octadiene ; 7-methyl-3-methylene-1 , 6-octadiene ; myrcene.
Synovial fluid plays an important role in lubricating synovial joints.
Syntactic flexibility was assessed using five syntactic operations : adverb insertion , adjective insertion , left dislocation , passive and movement.
Syntactic priming , the phenomenon in which participants adopt the linguistic behaviour of their partner , is widely used in psycholinguistics to investigate syntactic operations.
SynTgSod1 ( - / - ) mice expressed CuZnSOD in brain , spinal cord , and peripheral nerve , but not in other tissues.
Synthesis of findings show the DEU clinical model may increase student interest and knowledge of LTC nursing through collaboration with the practicing LTC nurse.
SYNTHESIS : Significant improvements were detected on postural control.
Synthesizing this myriad of aspects will lead to improved treatment options for patients with osteoporosis who are suffering from spinal deformities.
Synthetic lethal genes to mutant p53 can be divided into cell cycle regulators and non-cell cycle regulators.
Synthetic materials have been developed and applied in various parts of human body to meet the biomedical needs.
Synthetic soluble Aβ oligomers are often used as a surrogate for biologic material in a number of model systems.
Synuclein is a soluble , natively unfolded protein that is highly enriched in the presynaptic terminals of neurons in the central nervous system.
Systematic approaches to case-finding individuals who are at high risk of sustaining fragility fractures are described.
Systematic assessment and site-specific nonsurgical rejuvenation of the midface may lead to increased safety , accuracy , and technique reproducibility in this commonly injected region.
Systematic assessment of the DTA plaques was performed using a biplane mode from the aorta at the level of the stomach to the aortic arch.
Systematic characterization of this ' ground state ' immunity in comparison with memory will allow a better understanding of clonal selection during immune challenge.
Systematic collection and analysis of personality data alongside HRQOL measures may be helpful in medical research , clinical practice , and health policy evaluation.
Systematic evaluation of case reports , registries and , ultimately , randomized clinical trials are needed to elucidate potential benefit for patients.
Systematic evaluation of preoperative frailty should play a key role in decision making for patients undergoing surgery for primary spinal tumors.
Systematic follow-up of adults with CP appears necessary to timely detect and intervene in health problems and functional decline.
Systematic increase in rate over the study period , with the @percent@ in last year compared to @number@ year can be noticed.
Systematic non-response threatens the validity of results.
Systematic review of the literature : level of evidence IV.
Systematic Review Registration Number : PROSPERO 2014 : CRD42014009091.
SYSTEMATIC REVIEW REGISTRATION : PROSPERO CRD42014014008.
SYSTEMATIC REVIEW REGISTRATION : PROSPERO CRD42015019198.
SYSTEMATIC REVIEW REGISTRATION : PROSPERO CRD42016045692 .
SYSTEMATIC REVIEW REGISTRATION : PROSPERO CRD42016052762.
Systematic reviews focus on quantitative studies and there is a lack of qualitative reviews in the area.
Systematic reviews of literature relevant to driving and community mobility for older adults are important to the practice of occupational therapy.
Systematic reviews were performed of the prevalence , incidence , remission , duration and mortality risk of neck pain.
Systematic studies of PROs have not been conducted in the lower face.
Systemic adverse effects of smoking may be mediated by pathways associated with F2RL3 methylation.
Systemic analgesia , such as opioids , can lead to untoward side effects , especially in this particular group of patients.
Systemic and CD163 ( + ) eye macrophages obtained from AMD patients also demonstrate STAT3 activation.
Systemic and inhaled corticosteroids were prescribed at higher rates of @percent@ and @percent@ compared to long-acting bronchodilators.
Systemic ANS tests may not be useful in detecting the underlying physiologic changes that lead to LUTS in aging men.
Systemic arterial hypertension is an age-dependent disorder , and almost half of the elderly human population is hypertensive.
Systemic conditions impairing the patient's immune competence , such as diabetes , may play a predisposing role.
Systemic control of diabetes can improve ocular surface health , possibly aided by anti-inflammatory and vasoprotective agents.
Systemic hemodynamic parameters during tasks as well as cognitive scores had no correlation with cerebrovascular measurements ( P > @number@ ) .
Systemic hypoxia is a physiological and pathophysiological stress that activates the sympathoadrenal system and , in young adults , leads to peripheral vasodilation.
Systemic inflammation also affects the kidney via pro-inflammatory cytokines and infiltration of inflammatory cells , and autophagy also has a regulatory role in systemic inflammation.
Systemic inflammation seems to be an important factor for its establishment and repeated bursts of inflammatory mediators during COPD exacerbations could further inhibit erythropoiesis.
Systemic inflammation was assessed by suPAR , TNFα , and IL-6.
Systemic inflammation was assessed with a composite measure of commonly used circulating inflammatory markers ( C-reactive protein and tumor necrosis factor-alpha ) .
Systemic loss of neutral sphingomyelinase ( SMPD3 ) in mice leads to a novel form of systemic , juvenile hypoplasia ( dwarfism ) .
Systemic lupus erythematosus is an autoimmune disease that results in nephritis and subsequent destruction of renal microstructure.
Systemic medical conditions can have a negative impact on oral health.
Systemic VEGF inhibition disrupts endothelial homeostasis and accelerates the atherogenesis , suggesting that these events contribute to the clinical cardiovascular adverse events of VEGF-inhibiting therapies.
Systemizing is defined as the drive to analyze a system in terms of the rules that govern the system in order to predict its behavior.
Systems biology is becoming an essential tool to investigate disease initiation and disease progression.
Systems employing VR can include desktop and head-mounted visual displays among other devices.
Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing.
Systems redesign processes were effective for redesigning the tool and implementing practice changes with clinicians involved in dysphagia screening.
System-wide approaches are now being applied to study vaccine responses , whose mechanisms of action , and failure , are not well understood.
Systolic and diastolic blood pressure levels were @number@ and @number@ mmHg higher , respectively.
Systolic and diastolic BPV was calculated using the coefficient of variation ( CV ) and standard deviation method.
Systolic blood pressure levels were up to @number@ mmHg lower in naturally post- compared to premenopausal women at all ages between @number@ and @number@ years.
Systolic blood pressure responsivity ( SBP-R ; reflective of effort ) and subjective perceptions of task difficulty were assessed.
Systolic blood pressure ( SBP ) and oxygen saturation were unchanged after the procedure.
Systolic BP ( SBP ) was grouped in 10-mmHg increments from less than @number@ to @number@ mmHg or more ( reference 145-154 mmHg ) .
Systolic function of the left ventricle were evaluated in echocardiography.
Systolic hypertension , the predominant form of hypertension in patients aged over 50-60 years , is a growing health issue as the Asian population ages.
Systolic transvalvular pressure gradient ( TPG ) and the effective orifice area are commonly used to grade the severity of valvular dysfunction.
T1-11 exerted a therapeutic effect on HD transgenic mouse by decreasing protein level of polyglutamine-expanded huntingtin in the striatum.
T1-11 [ N6- ( 4-Hydroxybenzyl ) adenosine ] , isolated from a Chinese medicinal herb Gastordia elata , is an adenosine A2A receptor agonist.
T1-11 or JMF1907 ameliorated the symptom of motor incoordination displayed by SCA3 mouse.
T1-11 or JMF1907 significantly augmented the chymotrypsin-like activity of proteasome in the pontine nuclei or cerebellum of SCA3 mouse.
T1 and T2 lesions were automatically segmented using an edge-finding tool and total lesion volumes were calculated.
T1 and T2 values of the extra-ocular muscles increased with age , with higher T1 and T2 values compared to the masseter muscles.
( T1D and LADA ) .
T1D prevention by this reagent occurred by a Th2 / TR-1 polarization in the pancreas.
T1 measurements pre-contrast and post-contrast in a cardiac magnetic resonance ( CMR ) study provide a method for quantification of ECV.
T1-weighted 3T MRI scans were used to evaluate gray matter cortical thickness.
T1-weighted axial MR imageswere acquired at the facet joint level from individual patients.
T1-weighted high-resolution ( @number@ × @number@ × 1mm ( @number@ ) ) images were acquired.
T1-weighted magnetic resonance imaging scans were acquired in @number@ MA and @number@ OA adults from respective random community samples.
T1-weighted MRI was used to create models of the cortex for calculation of regional cortical thickness.
T1 weighted structural MRI and Diffusion Tensor Imaging data from @number@ healthy participants from the Brain Resource International Database was used for this study.
T1WI , T2WI and diffusion-weighted MR images ( DW MRI ) were obtained and bilateral parotid , submandibular and sublingual glands segmented manually.
T1ρ maps were calculated and atlas-based segmentation used to determine regional T1ρ values.
T21F had high SOD1 expression and activity which led to an interenzymatic imbalance in the antioxidant defense system , accentuated with replicative senescence.
T2DM arises largely from obesity , poor diet , and lack of exercise , but it also involves genetic predisposition.
T2DM was ascertained by glycated haemoglobin level , self-report , hypoglycaemic medication use and clinical records.
T2 FLAIR axial images were analyzed using the AIS WMH volumetric , protocol and compared with the ARIC ( gold standard ) method.
T2 maps analysis suggested that water distribution did not change.
T2 of the deep and superficial femorotibial cartilages was determined in @number@ femorotibial subregions , using a multi-echo spin-echo ( MESE ) MRI sequence.
T2 relaxation times and cartilage thickness were greater in males than in females ( p < 0.05 ) .
T2 values in all three compartments were evaluated according to age and gender.
T2 values were measured at patellar cartilage , posteromedial and posterolateral femoral cartilage adjacent to the central horn of posterior meniscus.
T3 was thought to act predominantly through pathways that require transcriptional regulation by thyroid hormone receptors ( TRs ) .
T5 burden and Sequence Kernel Association ( SKAT ) gene-based tests assessed functional variants with MAF≤5%.
Tables are provided to convert raw scores to scaled scores.
Tabulated treatment planning will also present algorithms summarizing a logical approach to the treatment of more-minor grades of scarring.
Tachycardia therapy ( ablation and implantable ) was administered in @percent@ ( annually @percent@ ) of patients with nonperioperative tachycardia.
Tacrolimus has been shown to be associated with better QOL than cyclosporine ( ciclosporin ) , as has corticosteroid-free immunosuppressive regimens.
Tactile extinction was the most frequent subtype with a prevalence of @percent@ ( @percent@ CI @date@ @number@ ) .
Tactile sensory performance , manual dexterity ( \ "haptic efficiency \ " ) , and the subjective response to tactile stimulation were quantified.
Tadalafil had a reassuring safety profile and no evidence of increased cardiovascular AEs in aging men.
Tadalafil was not statistically significantly better than placebo in men aged ≥75 years , but effect size varied between studies.
T administration did not add to the effect of physical training.
T'ai chi and meditation plus exercise include mental and physical training.
Tai Chi has many benefits for middle-aged / older individuals including improvements to muscle strength and various body lipid components.
Tai Chi practitioners displayed better arm movement control than ONPs on a relatively challenging and functional stand-reaching task.
Tai Chi ( TC ) is a multisystem intervention that reduces fall risk , yet its impact on sway measures vary considerably.
Tailored calendar journal pages were used to document falls daily and returned by mail monthly.
Tailored calendar journals and incentives may be effective in ascertaining falls among community-dwelling older adults.
Tailored fall prevention screening and intervention may be of value in populations younger than those traditionally screened.
Tailoring news releases to a particular mass media outlet increases the possibility that the release will result in a published story.
Tailor their approach to face lifting based on patient anatomy.
Taken altogether , our study demonstrates a role of miR-155 in thiamine homeostasis and suggests a function of this oncogenic miRNA on breast cancer metabolism.
Taken as a whole , results support a modest yet significant improvement in cardiac function in cell-treated patients.
Taken from these reviews , we here pinpoint several topics fit for future attention.
Taken overall , these data suggest that LD-1227 has the potential to be included in the nutraceutical armamentarium in the management of OA.
Taken together , age and temporal lobe ADC accounted for a striking @percent@ of the variance in memory scores within the ε4 carrier group.
Taken together , age-related increases in prefrontal activity and reduced amygdala activity may underlie observed affective changes in aging.
Taken together , CDP inhibits UVB-induced MMP-1 expression in skin fibroblasts by suppressing expression of AP-1 and CYR61 and MCP-1 production.
Taken together , DNA damage and repair capacity can be a biomarker of aging.
Taken together , increased amygdalar volume may serve as a significant marker of anxiety , regardless of developmental phase.
Taken together , it appears that the developmental mismatch in structural brain maturation is present in neurotypically developing individuals.
Taken together , it is suggested that aging reduces the ability to modify eye movements to meet various behavioral constraints imposed on manual aiming tasks.
Taken together , our data demonstrate that AIMP3 / p18 regulates cellular aging in hMSCs possibly through miR-543 and miR-590-3p.
Taken together , our data further support the model that lysine deacetylases are selective regulators of DNA binding proteins.
Taken together , our data provide evidence that RBM24 is a novel regulator of p63 via mRNA stability.
Taken together , our data provide further evidence on the beneficial effects of testosterone , which may be useful for future drug development for AD.
Taken together , our data suggest that eupatilin inhibits TNFα-induced MMP-2 / -9 expression by suppressing NF-κB and MAPK⁄AP-1 pathways via PPARα.
Taken together , our data suggest that SHQA inhibit TNFα-induced MMP-2 / -9 expression and age-related inflammation by suppressing AP-1 and NF-κB pathway via PPARα.
Taken together , our data supports a biological role for CSB and NEIL2 in transcription associated base excision repair.
Taken together , our findings imply that aging disturbs the balance between Treg cells and Teff cells.
Taken together , our findings reveal that lower theta inter-trial coherence is related to greater behavioral variability within and across age groups.
Taken together , our findings suggest that targeting BIS or HSF1 could be a viable therapeutic strategy for GSCs resistant to conventional TMZ treatment.
Taken together , our present study provides compelling evidence that engineered minibody is more effective and promising agent for in vivo targeting of solid tumors.
Taken together , our results demonstrated that the relative Bcl-2 expression decreased with aging , while Bax expression was upregulated compared to 10-year-olds.
Taken together , our results indicate that age-related autoimmunity contributes to development of DED with aging.
Taken together , our results indicate that both microglia and neurons produce GlcNAc polymers , which trigger neurotoxicity both directly and through microglia activation.
Taken together , our results indicate that increased E2 is one of the initiating signals that trigger liver regeneration.
Taken together , our results revealed an important role of Wnt signaling in FTLD-TDP pathology and suggest a novel target for therapeutic intervention.
Taken together , our results suggest that canonical Wnt signaling and its antagonist , sFRP1 , regulate proliferation of human CSCs.
Taken together , our results suggest that circRNA 100269 and miR-630 comprise a novel pathway that regulates proliferation of GC cells.
Taken together , our results suggest that hUCBSC have the potential to inhibit the angiogenesis of glioma cells both in vitro and in vivo.
Taken together , our results suggest that multiple pathways are potentially involved in MG-induced neuron death.
Taken together , our results suggest that targeting Mcl-1 with KRIBB11 treatment , while simultaneously downregulating BIS , could be a therapeutic strategy in NSCLC.
Taken together , oxidative stress considerably accelerated telomere shortening and cellular aging in chondrocytes.
Taken together , recovery from functional hypothalamic amenorrhea putatively offers neuroprotection and ameliorates stress-induced premature brain aging and possibly syndromic Alzheimer's disease.
Taken together , results from this study may provide the basis for future anti- atherosclerotic drug development mediated through RAGE activation.
Taken together , results of this study may contribute to developing new cognitive intervention programs in older adults presenting with proper-name anomia.
Taken together , results suggest that PMF exposure does not interfere with genotoxicity and cytotoxicity induced by oxidative stress.
Taken together , results suggest that the processing of decision-relevant information promotes a stronger focus on negative information in older adults.
Taken together , serum IgG antibody titer test is useful in the prognosis of periodontitis recurrence during the SPT phase.
Taken together , the cellular model have important implications for understanding the molecular exploration of Dental pulp stem cells senescence and aging.
Taken together , the findings are consistent with the notion that aging overrides the effect of sleep loss on the genetic damage in elderly mice.
Taken together , the findings from human patients , yeast , and a mouse model implicate the polyamine pathway in PD pathogenesis.
Taken together , the findings suggest that the neural mechanisms engaged during successful episodic retrieval can remain stable with advancing age.
Taken together , the neuroprotective , including preservation of pre-synaptic proteins by AGE and SAC can be utilized in future drug development in AD.
Taken together , the present study demonstrated that methyl caffeate might be a specific and strong inhibitor of SASP production without affecting the aging process.
Taken together , the present study provides new insight into the role of KY17 as a potential antitumor compound.
Taken together , the results demonstrate a new source of MSCs with a high potential for application in tendon repair.
Taken together , the results encourage broader activities in disability measures to capture better disability's scope and dynamics.
Taken together , the results indicate no age-related decline in the capabilities to process faces holistically.
Taken together , the results showed that human masseter and biceps muscle spindles are morphologically mature already at young age.
Taken together , the results suggest a dissociation of preview benefit and parafoveal-on-foveal effect.
Taken together , these considerations place RAGE in the center of biochemical and molecular stresses that characterize the complications of diabetes and chronic disease.
Taken together , these data demonstrate an important role for USP47 in regulating DNA repair and maintaining genome integrity.
Taken together , these data identify brain hypermetabolism in Tg2576 mice which cannot be accounted for by changes in vascular compliance.
Taken together , these data indicate that APO10LA can effectively inhibit HFD-promoted hepatic tumorigenesis by stimulating SIRT1 signaling while reducing hepatic inflammation.
Taken together these data strongly indicate that the presence of a basal level of telomere-associated DDR is a determinant of susceptibility to G4 stabilization.
Taken together , these data suggest a concomitant loss of functional capillaries and brain volume in AD subjects.
Taken together , these data suggest that acute lower limb heating improves both macro- and microvascular dilator function in an age dependent manner.
Taken together these data suggest that AD patients are associated with chronic disturbance of @number@ , 3-diphosphoglycerate metabolism in erythrocytes.
Taken together , these data suggest that age-related changes in MSC population dynamics result in impaired therapeutic potential of aged progenitor cells.
Taken together , these data suggest that both age and sex differences affect cardiac amyloid formation , mainly derived from WT TTR , in FAP.
Taken together , these data suggest that Eucalyptus globulus may be a useful agent in cosmetic products.
Taken together , these data suggest that reduction in PGC-1α expression and disruption of mitochondrial dynamics and autophagy might contribute to lipid accumulation during aging.
Taken together these data suggest that regular engagement in ultra-endurance aerobic exercise attenuates cellular aging.
Taken together , these data suggest that there are age-related differences in the catabolism of proteoglycans in human skin.
Taken together , these data suggest the operation of certain senescence-associated functional nuclear barriers by down-regulation of the nucleo-cytoplasmic trafficking genes in the senescent cells.
Taken together , these data support the notion that BLVRA contributes significantly to modulation of the aging process by adjusting the cellular oxidative status.
Taken together , these elements are a call to action for research and practice psychologists who are working to improve the lives of gay men.
Taken together , these examples imply that aging may modify breast cancer risk , prognosis and treatment.
Taken together , these findings highlight EF-and not simply cognition in general-as a potential determinant of well-being in oneself and one's partner among aging couples.
Taken together , these findings identify CRIM1 as the causative gene for MACOM syndrome and emphasize the importance of CRIM1 in eye development.
Taken together , these findings indicate that GRK5 dysfunction accelerated tau hyperphosphorylation in APP ( swe ) mice by activating GSK3β through impaired cholinergic activity.
Taken together , these findings may reflect a generalized reduction in inhibitory processes.
Taken together , these findings suggest novel nesprin-2 functions in cellular signaling.
Taken together , these findings suggest that the phenotype of HGPS represents a unique skeletal dysplasia.
Taken together , these findings warrant further investigation of the potential therapeutic benefit of MAO-B inhibitors in patients with AD and other neurologic disorders.
Taken together , these findings were consistent with ABS , and critical observations on coronary angiography indicated the diagnosis by exclusion.
Taken together these observations led us to hypothesize that mast cells activity could be involved in both negative emotionality and telomere shortening in mastocytosis.
Taken together , these results demonstrated that CCL5 promotes VEGF-dependent angiogenesis in human chondrosarcoma cells by downregulating miR-199a.
Taken together , these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senescence.
Taken together , these results indicate that CLDN8 functions as an AR downstream signal to facilitate the progression of prostate cancer.
Taken together , these results indicate that healthy aging largely leaves judgments of learning intact for negatively charged words.
Taken together , these results indicate that men and women lose vertebral bone differently with age , particularly in the peripheral ( cortical ) compartment.
Taken together , these results show that emotion has beneficial effects on visual short-term memory in ageing and AD.
Taken together these results show that this nutricosmeceutical supplement may have photo-protective effects and help improve skin health.
Taken together , these results show the maturation of performance monitoring capacity to depend on more focal engagement of posterior MFC substrate for cognitive control.
Taken together , these results suggest an effect , but an overall limited burden , of harboring a single GBA mutation in aging mutation carriers.
Taken together , these results suggested that compound 8b down-regulates the expression of hTERT and induces mitochondrial-dependent apoptosis.
Taken together , these results suggest that eIF5B silencing provides a negative feedback to deactivate MAPK signaling , leading to reduced cell growth.
Taken together , these results suggest that future genome-wide analyses can benefit substantially by taking into account the phenotypic and genetic heterogeneity of BP features.
Taken together , these results suggest that , like its vertebrate counterparts , dAven plays a role in cell cycle regulation.
Taken together , these results suggest that MHY336 could be a potential candidate to be used in chemoprevention and / or treatment of colon cancer.
Taken together , these results suggest that PVI may indeed have beneficial effects on memory function in healthy young women.
Taken together , these results suggest that species comparisons of phosphoproteomic data may reveal regulatory principles in glomerular biology.
Taken together , these results suggest that SSeo has putative potential anti-atherosclerotic activity.
Taken together these results suggest that the oldest old with DLB might represent a distinct group.
Taken together , these results suggest that WBVT can off-set age related performance decrements , which has therapeutic implications for musculoskeletal aging.
Taken together , these results support a link between oxidative protein modifications and the altered cellular metabolism associated with the senescent phenotype of human myoblasts.
Taken together , these studies identify DDE as a compound well suited to prevent and reverse loss of subcutaneous fat.
Taken together , these studies suggest that KLVS leads to altered homodimerization that indirectly leads to changes in processing and FGFR1c interactions.
Taken together , these studies suggest that variation in entity versus incremental endorsement represents a key predictor of older adults ' memory performance.
Taken together , this study suggests that neurodevelopmental signatures impart differential trajectories towards neurodegenerative disease.
Taken together , underlying ER stress and UPR pathways are emerging as important determinants of fibrotic remodeling in different forms of tissue fibrosis.
Taken together , UVB-RHE emulate hallmarks of skin aging and might contribute to an improved non-clinical development of medicinal or cosmetic products.
Taken together , viscolin attenuated PDGF-BB-induced HASMC proliferation in vitro and reduced neointimal hyperplasia in vivo.
Taken together , we draw @number@ main conclusions.
Taken together , we show that human Pol α interacts with MSH2-MSH6 complex and propose that this interaction occurs during the mismatch repair reaction.
Taken together , we summarize the recent evidence to elucidate that Htt is also a potential substrate of CMA.
Taking a different approach , we investigated the variation in LAA morphology in a consecutive patient population with and without AF.
Taking a lifetime perspective , these costs shed new light on solidarity in health care.
Taking a multi-locus approach may increase the ability to identify individuals at highest risk for any AD syndrome.
Taking a pragmatic approach , we need to understand the drivers for immune decline if we are to consider intervening therapeutically in this process.
Taking care of non-self-sufficient people such as those with dementia causes distress.
Taking cognitive reserve into account may allow for earlier detection and better characterization of age-related cognitive changes and Alzheimer's disease.
Taking into account the high consumption of codeine , only few fatal adverse events have been published.
Taking physician-recommended sleep medications increases the risks for falling in older adults , irrespective of the presence of insomnia symptoms.
Taking reasonable precaution to prevent the postinflammatory hyperpigmentation is the most important point in making ALA-IPL PDT a successful therapy.
Taking the above into account , our aim was to quantify Greek adolescents ' exposure to SHS using serum cotinine levels.
Taking these results together , we conclude that CHIP-dependent p53 regulation occurs specifically during senescence.
Taking these results together , we propose that the VP2 protein of oncolytic H-1 parvovirus determines its specific tropism in human cancer cells.
Taking this advice as such , would mean that we should screen for ASCS and operate on all appropriate candidates.
Taking this into account , are articles on the elderly well represented in domestic medical journals ?
Taking this into consideration , we evaluated the levels of nitric oxide , reactive oxygen species , and superoxide dismutase activity.
Takotsubo cardiomyopathy ( TTC ) is a well-known condition , which leads to sudden transient regional systolic dysfunction.
Talking about sexual health can be a challenge for some older women.
Taller height was associated with lower concentrations of androstenedione , testosterone , free testosterone and sex hormone-binding globulin and higher concentrations of androstanediol glucuronide.
Taller men or women had longer eyes , with flatter corneas and less powerful lenses , independent of refractive error.
Taller persons had more distally positioned fixed ROIs which moved proximally when corrected.
Taller stature in both sexes and late growth in women were associated with better midlife cognitive performance.
Tamoxifen , a first generation SERM , is used for treatment of ER positive breast cancer.
T and E2 were not associated with musculoskeletal pain , whereas significant differences in LH and FSH levels were found between pain groups.
T and R signals are detected from a single reaction well containing the same input DNA.
Tangle density was associated with cortical ( p = @number@ ) and hippocampal atrophy ( p < @number@ ) .
Tankyrase @number@ a telomeric poly ( ADP-ribose ) polymerase ( PARP ) , elongates telomere length by inhibiting TRF1 binding to telomeres.
Tankyrase @number@ siRNA knockdown in human cells significantly elevated recombination specifically within telomeres , a phenotype with the potential of accelerating cellular senescence.
Tanned skin has long been viewed as attractive in today's culture.
Tannin-based agents ( Aroeira and PACs ) stained the specimens in dark brown color.
Tanshinones isolated from the plant including cryptotanshione , tanshinone I , and tanshinone IIa , are the active components.
Tanycytes are emerging as key players in the neuroendocrine control of gonadotrophin-releasing hormone ( GnRH ) release.
TA of MR images of anatomic structures in mild AD and aMCI is not well-studied.
Tape-strippings were carried out on the inner face of one forearm , the other unstripped forearm serving as control.
Tardive dyskinesia ( TD ) , a kind of dyskinesia , may develop after long-term antipsychotic treatment.
TAR DNA binding protein @number@ ( TDP-43 ) aggregates in the cytoplasm of neurons were also observed in aged PGRN-deficient mice.
TAR DNA binding protein @number@ ( TDP-43 ) is another protein linked to Alzheimer's disease.
TAR DNA-binding protein @number@ ( TDP-43 ) plays a key role in the neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Target Audience : Obstetricians and gynecologists , family physicians.
TARGET AUDIENCE : This continuing education activity is intended for physicians and nurses with an interest in skin and wound care.
Targeted analyses of meat and fish consumption did not replicate previous associations with total brain volume or total gray matter volume.
Targeted dissemination of this Curriculum ( in-person and online ) will allow more to benefit in the future.
Targeted exercise programs to increase physical activity and improve speed and power should be evaluated as interventions to improve QoL during ART.
Targeted experiments were performed by varying section age , thickness , cleanliness , slide brand and age , and sample size and fixation.
Targeted inhibition of both IL10 receptor-mediated signalling and STAT3 activation in macrophages reverses the ageing phenotype.
Targeted inhibition of MET / RON signaling by tyrosine kinase inhibitor BMS-777607 for cancer treatment is currently under clinical trials.
Targeted interventions are needed to improve overall quality of care for hospitalized older adults in rural settings.
Targeted manipulation of purine-metabolizing enzymes may benefit this vulnerable population.
Targeted next-generation sequencing was performed in the @number@ probands.
Targeted Pim1 overexpression in hCPCs allows for selection of the desired phenotypic properties to overcome patient variability and improve specific stem cell characteristics.
Targeted prevention and promotion measures should be offered both to men and women.
Targeted proteomics has emerged as a powerful approach for reproducible quantification but is limited in the number of proteins quantified.
Targeted therapy has become a powerful approach for cancer treatment.
Targeted voxel-based analysis localized this association to the hippocampus and entorhinal cortex.
Target identification studies showed that ADDN-1351 is a TrkA inhibitor , and , in complementary studies , TrkA overexpression increased AβPP-C31 and cell death.
Targeting BubR1 may represent a novel therapeutic strategy for age-related cognitive deficits.
Targeting cancer metabolism is a potential alternative strategy to counteract tumour growth and recurrence.
Targeting factors involved in ER-related protein processing and trafficking may , therefore , be a key to modulating αSyn levels and associated toxicity.
Targeting Klotho may provide novel strategies for future therapeutic intervention.
Targeting macrophage plasticity opens up new possibilities for more effective AMD treatment.
Targeting Notch regulation of TRPC6 will be beneficial in the development of novel therapies for pulmonary hypertension associated with hypoxia.
Targeting of LIS1 by miR-144 was confirmed by luciferase reporter assays.
Targeting OSA to reduce IR could be useful in the elderly , although further exploration is required.
Targeting osmosignaling pathways may represent a novel strategy to reduce vascular effects of hyperglycemia.
Targeting PI3K signaling may therefore offer a new strategy in improving neutrophil functions during infections and reduce inappropriate inflammation in older patients.
Targeting S6K1 may thus represent a novel therapeutic approach for aging-associated vascular disease.
Targeting SDC1 in these tumors might provide a novel therapeutic strategy.
Targeting SIRT1 / AMPK signaling by resveratrol may have potential therapeutic implications for cancer and age-related diseases.
Targeting the c-Jun / CCN1 axis may provide clinical benefit for connective tissue aging in human skin.
Targeting the intrinsic capacities of neuroprotective proteins to restore neuronal function and / or attenuate degeneration represents a potential means toward therapeutic intervention.
Targeting these pathways as therapies might improve clinical outcomes of EBV ( + ) DLBCL-E.
Targeting these pathways may improve outcomes of bacterial infection in elderly patients.
Targeting those at greatest risk such as the multimorbid or using simpler screening methods may be more effective.
Target of rapamycin ( TOR ) is an evolutionarily conserved nutrient-sensing protein kinase that regulates growth and metabolism in all eukaryotic cells.
Target pairs and regulatory networks of targets could reflect more potential interactions between targets and comprehensive effects on anti-aging.
Target pairs with high correlation related to anti-aging were also discovered by data mining algorithm.
TARGET POPULATION : U.S. adults aged @number@ to @number@ years.
Target proteins of these herbal medicines were obtained from bioinformatics databases.
Target samples size is @number@ drivers.
Targets in a recognition exclusion task were words encoded using two alternative decisions.
Target speech was presented without noise , with fluctuating speech-shaped noise , or with competing speech from a single distractor speaker.
Target's salience and distractors ' numerosity were manipulated , while accuracy and reaction times were recorded as dependent variables.
Target stimuli and three-dimensional scenarios were judged adequate and the content analysis demonstrated that ECO-VR evaluates temporo-spatial orientation , memory , language and executive functioning.
Targets were presented in the frontal field by a robotically controlled loudspeaker assembly hidden behind a screen.
Targets were single lines of high-contrast letters based on the Bailey-Lovie chart.
Targets were systematically placed in regions that extended @number@ @number@ @number@ and @number@ degrees from center.
Target therapy might be considered in EGFR and c-MET-mutated patients.
T. arjuna bark extract decreased TEWL , improved skin moisturization , reduced scaliness and led to significantly improved skin elasticity.
Tarsal fixation and lipoinfiltration are major advances in secondary upper lid blepharoplasty.
Tartrate-resistant acid phosphatase type 5b ( TRAP-5b ) is derived from osteoclasts , and is involved in normal bone homeostasis.
Task-absent resting-state fMRI ( RS-fMRI ) assessed atDCS-induced changes at the network level independent of performance.
Task difficulty was modulated to investigate differential activation for precise control of gait.
Task instructions were manipulated to separate age-related differences in the specificity of underlying memory representations from age-related differences in following task instructions.
Task performance for behaviors that engage motor cognitive processes may be particularly sensitive to age-related changes.
Task performance ( matching accuracy , reaction times ) did not differ across age.
Task performances , racket oscillation , ball-racket impacts as well as the ball-racket coupling were analysed.
Task performance was also correlated with regions associated with effortful verbal processing , working memory , and performance monitoring.
Task performance was assessed by recording motor imagery latencies , eye movements , and electromyography during functional magnetic resonance imaging scanning.
Task performance was monitored by simultaneous MR-compatible video recording.
Task-related deactivation in the precuneus demonstrated much greater variability than hippocampal activation in all analyses.
Task-related fMRI data were concurrently acquired.
Task-related increases in theta power were observed at frontal , temporal and parietal electrode sites during fact and source retrieval.
Task shifting is suggested as a strategy to reduce the costs of delivering home-care services.
Task shifting refers to the delegation or transfer of tasks from regulated healthcare professionals to home-care workers ( HCWs ) .
Tasks included a control and an experimental condition : during both tasks individuals had to solve simple mental arithmetic problems.
Task-switching performance relies on a broadly distributed frontoparietal network and declines in older adults.
TAS , OSI , PON and stim-PON were comparable.
Taste receptor cells detect nutrients and toxins in the oral cavity and transmit the sensory information to gustatory nerve endings in the buds.
Taste was identified as the most important meat quality attribute ( perceived as [ very ] important by @percent@ of the respondents ) .
Tat-activating regulatory DNA-binding protein-43 ( TDP-43 ) acts as an InSAC scaffold that selectively associates with IL-6 and IL-10 RNAs in a sequence-specific manner.
TAT appears to be the most appropriate source of angiogenic and endothelial factors in elderly cardiomyopathy subjects compared to SAT.
Tat but not Nef induced an early increase in NF-κB activity and cytokine / chemokine secretion.
Tat-induced effects were prevented by the NF-κB inhibitor parthenolide , indicating that Tat triggered senescence via NF-κB activation leading to oxidative stress.
TAU.
Tau accumulates in progressively larger and more heterogeneous forms in brains with neurofibrillary pathology.
Tau and MAP2 , but not α-synuclein depositions , were also found in Aβ aggregates.
Tau deposition in the brain may have a relationship with systemic causes of death , including cancer , in the cognitively normal elderly.
Tau deposits detected by immunohistochemistry.
Tau deposits were immunonegative with a phosphorylation-dependent antibody.
Tau gene mutations have been found in frontotemporal dementia with parkinsonism linked to chromosome @number@ suggesting that mutation of tau induces tauopathy.
Tau hyperphosphorylation has been attributed in part to the deregulation of kinases and phosphatases activities.
Tau hyperphosphorylation is a critical event in Alzheimer's disease , in which the neuronal Golgi fragmentation occurs earlier than tau hyperphosphorylation.
Tau imaging agents offer the opportunity of in vivo topographical mapping and quantification of tau aggregates in parallel with clinical and cognitive assessments.
Tau immunohistochemistry performed in @number@ brain regions and quantitative assessment of regional tau load using image analysis were performed.
Tau is a microtubule-associated protein exerting several physiological functions in neurons.
Tau mutations cause FTD , but how mutant tau impairs the salience network is unknown.
Tauopathic patients have significant cognitive decline accompanied by irreversible and severe brain atrophy , and it is thought that neuronal dysfunction begins years before diagnosis.
Tauopathies are a group of disorders in which the cytosolic protein tau aggregates and accumulates in cells within the brain , resulting in neurodegeneration.
Tauopathies are a group of disorders leading to cognitive and behavioral impairment in the aging population.
Tauopathies are characterized by hyperphosphorylation of the microtubule-associated protein tau and its accumulation into fibrillar aggregates.
Tauopathies are characterized by the accumulation of filaments of the microtubule-associated tau protein.
Tauopathies are neurodegenerative diseases characterized behaviorally by dementia and neuropathologically by neurofibrillary tangles and neuronal loss.
Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain.
Tauopathies , the most common of which is Alzheimer's disease ( AD ) , constitute the most crippling neurodegenerative threat to our aging population.
Tau PET imaging has also revealed characteristic spatial patterns among various non-AD tauopathies , supporting its potential role for differential diagnosis.
Tau phosphorylation is under the control of multiple kinases and phosphatases , including Fyn.
Tau protein is the major component of all of these ultrastructures.
Tau-related therapies are also under clinical investigation but few compounds are available.
Taurine supplementation might help forestall the age-related decline in cognitive functions through interaction with the GABAergic system.
Tau transgenic mice subjected to acute neuronal injury using 3-nitropropionic acid showed increased interstitial fluid tau and plasma tau.
Tau was identified as microtubule associated protein and was implicated in microtubule initiation as well as assembly.
Tau was observed in microglia , but its role is not illustrated.
TA was elevated in MPN but borderline in MDS , probably because of differences in the nature of the diseases.
TAZ-knockdown does not stimulate EGCG-induced myogenic differentiation.
Tbata is expressed in thymic stromal cells and interacts with the enzyme Uba3 , thereby inhibiting the Nedd8 pathway and cell proliferation.
TBB was performed again and the tumor was diagnosed as SCC.
TBG was negatively associated with BMC and areal BMD at all sites.
TBI-exposed older adults may be ideal candidates for aggressive fall-screening and prevention strategies.
TBI pathophysiology is complicated and can be distinguished by the initial primary injury and the subsequent secondary injury that ensues days after the trauma.
TBK1 sequences were analyzed in @number@ consecutive patients with sALS using either multigene panel or exome sequencing.
TBS values were analyzed using three-way and one-way ANOVA , followed by post hoc Scheffé-test , and two-sample Student's t-tests.
TBS was analyzed using one-way ANOVA with Scheffé post hoc , unpaired Student t , Mann-Whitney U , Kruskal-Wallis H , and chi-squared tests.
TBV , standardized to head size , is estimated quantitatively from brain magnetic resonance imaging.
TBV was not associated with drinking status or amount consumed in men or women.
TCA use was associated with a higher risk of nonspine fracture , but this association was in part explained by confounding factors.
TCA use was associated with an increased risk of nonspine fracture in age-adjusted models , but in multivariable models this risk was attenuated.
T cell cytokines were also found to be a chemoattractant.
T-cell exhaustion has been identified as a state of hyporesponsiveness that arises under continuous antigenic stimulus.
T-cell immune activation and senescence were analyzed in a subgroup of @number@ patients by flow cytometry.
T-cell proliferative and cytokine-producing capacities were analyzed by stimulation with overlapping peptides spanning the large HDV antigen.
T-cell receptor rearrangement excision circle ( TREC ) levels , telomere length and telomerase activity in peripheral blood cells were quantified by real-time PCR.
T cell receptor ( TCR ) diversity is critical for adaptive immunity.
T cell responses can be regulated by macrophages and may depend on the functional phenotype macrophages adopt in response to microenvironmental signals.
T cells from untreated patients produced less IL-2 , possibly underlying their decreased proliferative abilities.
T cells have been extensively studied in this context due to the initial discovery of their reduced proliferative capacity with aging.
T-cells showed increased expression of the effector molecules perforin and interferon-γ with high expression of the transcription factor T-bet.
T-cell subsets in peripheral blood were measured by multi-colored flow cytometry.
T cells were activated for @number@ h with costimulation of @number@ IU / ml interleukin-2 ( IL-2 ) and @number@ μg / ml of anti-CD28.
T cells were activated through T-cell receptor before apoptosis and proliferation measurements.
T cell V genes are also skewed in targeting mutations but to a lesser extent and are lacking the codon usage bias observed in BCRs.
TCM , including Chinese herb medicine , acupuncture , and other nonmedication therapies , has its unique therapies in treating neurological diseases.
TCM is used frequently in China , and its impact on quality of life needs further investigation.
TCM syndrome typing was performed.
TCM users were identified as participants who reported visiting a Chinese medicine clinic in the year before each of the three interviews.
TC-naïve participants then completed a 6-month , two-arm , wait-list randomized clinical trial of TC training.
TCSs were categorized according to treatment : surgery , radiotherapy ( RT ) , or chemotherapy ( CT ) .
TD can be caused by primary testicular failure , decreased LH secretion ( secondary ) or a combination of both ( mixed type ) .
TDF maintained biochemical and virological response throughout the follow-up.
TDI e ' was nonlinearly associated with incident HF or death , with inflection points for risk supportive of ARIC-based limits.
TDMRs have been useful in various applications , particularly medicine and forensic sciences.
TDP-43 also recruits key spliceosomal components from Cajal bodies.
TDP-43 degradation was observed in the absence and presence of selective inhibitors and small interfering RNAs against the proteasome and autophagy.
TDP-43 inclusions are also found in up to approximately @percent@ of Alzheimer's disease ( AD ) brains.
TDP-43 is a key disease protein for amyotrophic lateral sclerosis but how it drives motor neuron degeneration remains unresolved.
TDP-43 is well known as being actively degraded by both the proteasome and macroautophagy.
TDP-43 Obesity is an induced health problem that human beings have been facing with non-optimal treatment so far.
TDP-43 pathology is a disease hallmark that characterizes amyotrophic lateral sclerosis ( ALS ) and frontotemporal lobar degeneration ( FTLD-TDP ) .
TDP-43 without HS was separately related to lower episodic memory.
TDS may be a new adjunctive neurorehabilitation regimen in treating tongue-disabled patients.
Teachers and researchers are valuable resources of universities.
Teachers , apart from having this perception had more problems in the VR-QOL questions of the physical domain , related to the professional requests.
Teaching for a practice is more than the dissemination of knowledge and information to the learner.
Tea intake was associated with lower risk of incident NCD , independent of other risk factors.
TEA is characterized by recurrent episodes of acute transient amnesia lasting less than one hour.
TEA is characterized by recurring amnestic seizures and is commonly associated with persistent interictal memory deficits.
Tea is most popular beverage in the world because of its attractive aroma , exceptional taste , health promoting and pharmaceutical potential.
Team grant # CIF @number@
TE and HE underwent a supervised exercise program ( @number@ day / week ) .
TEA participants ' performance was compared to @number@ matched healthy control participants.
Tea polyphenols enhance osteoblastogenesis and suppress osteoclastogenesis in vitro.
Tea polyphenols ( TP ) is one of the most used antioxidants and exerts beneficial effect on neurodegenerative diseases.
Tear flow rates were estimated from time taken to collect a fixed volume of tear fluid.
Tear meniscus values were negatively correlated with age in healthy Chinese subjects.
Tear production decreased to the trough at @number@ month after treatment and then recovered gradually.
Tear production was markedly reduced in all these patients.
Tears of the human supraspinatus tendon are common and often cause painful and debilitating loss of function.
Tears were collected to quantify the levels of diadenosine polyphosphates Ap4 A and Ap5 A by high-performance liquid chromatography ( H.P.L.C ) .
Tear trough deformity is one of the most difficult depressions to correct surgically.
TECHNIQUE : Realization of an upper fragment of circular muscle of eyelids turned on itself during a upper blepharoplasty with fat autograft.
Techniques that selectively elevate the lateral brow are more likely to have a rejuvenating effect on the upper third of the female face.
Techniques to date have largely relied on multiple injections , fanning techniques and deep placement of product under muscle or on periosteum.
Technological advancements in electronic health can be a driving force for new health management models , especially in chronic care.
Technological improvements continuously accelerate high-throughput tissue processing , image acquisition , and morphological reconstruction.
Technologies and ICTs can help elderly people to improve their quality of life , to be healthy and independent and to get better assistance.
Technologies have become a major force in people's lives.
Technologies that provide immersive experiences continue to become more ubiquitous across all age groups.
Technology can simplify the task and facilitate daily data collection.
Technology in the form of telehealth is one important tool to improve the efficiency of health care delivery.
Technology use did not vary by group membership once the covariates of age , gender , and living arrangements were accounted for.
TECs synthesize thymulin peptide that is required for T-cell differentiation and maturation within the thymus gland.
Tectal plate tumors are intrinsic midbrain tumors that behave more like hamartomas than neoplasms.
TEE and AEE from the Mini and 7D-PAR were each compared with values from the DLW.
TEE and EI values , EI-to-TEE ratios and EI-TEE values were compared.
T.E.E.N.S. participants who consent to MI Values are randomized to either MI or an education control condition.
Teeth were assigned randomly to five groups ( n = @number@ ) and restored with incrementally placed composite restorations.
Teeth were cut into sticks and the microtensile bond strength ( μTBS ) to dentin was tested in a universal testing machine.
Tel Aviv participants ( n = @number@ ) were evaluated on attention , executive function and psychomotor speed tasks.
Telecardiology has recently been investigated as a means of constantly monitoring the heart rate of CHF patients in their homes.
Telecommunication technologies may overcome limitations related to test administration.
Telemedicine provides potential for more effective care management of leg and foot ulcers.
Telemedicine provision does improve rural residents ' health status.
Telemonitoring transmitted vital signs and clinical alerts daily to a central nursing station.
Telencephalic neurocircuitry that plays functional roles in spatial learning and memory includes hippocampus , dorsal striatum and medial prefrontal cortex.
Teleologically , the relative preservation of nasal fat may be due to its higher abundance of neural-crest progenitor cells.
Tele-ophthalmology has the potential to improve operational efficiency , reduce cost , and significantly improve access to care.
Telephone follow-up calls after discharge is a potentially cost-effective strategy to identify these patients and potentially provide comfort and timely referrals where needed.
Telephone interviews were completed for @number@ women to ascertain the circumstances , injuries and medical care associated with falling.
Telephone or face-to-face counseling sessions were not of interest for this review.
Telephone use was not associated with communicative difficulties or depressive symptoms.
Tele-PST participants were satisfied with videoconferenced sessions because they were convenient and allowed them to see their therapist.
Telepsychiatry , internet-delivered therapy programs and bright-light therapy were used in managing symptoms associated with depression.
Telerehabilitation is an emerging approach that is being used for the effective treatment of multiple diseases , and is beginning to show promise for stroke.
Television is the most important source of information about DSWL.
Television ( TV ) viewing is known to affect children's verbal abilities and other physical , cognitive , and emotional development in psychological studies.
Telomerase activation by pioglitazone in cultivated cells was prevented by Akt inhibitors.
Telomerase activation , therefore , might serve as a viable therapeutic strategy to delay the onset of cellular senescence , tissue dysfunction and organismal decline.
Telomerase activity declined with age in the resting T-cells and B-cells and the activated T-cells.
Telomerase activity is tightly regulated by expression of human ( h ) TERT at both the transcriptional and post-translational levels.
Telomerase can also act as a transcriptional modulator of the Wnt-β-catenin signalling pathway and has RNA-dependent RNA polymerase activity.
Telomerase can elongate telomeres.
Telomerase contributes to cell proliferation and survival through both telomere-dependent and telomere-independent mechanisms.
Telomerase deficiency in patients with CHH is not mediated by abnormal telomerase gene transcript levels relative to those of endogenous genes.
Telomerase depends upon a complex pathway for enzyme assembly , localization in Cajal bodies , and association with telomeres.
Telomerase expression and activity appear elevated in > 80% of human cancers.
Telomerase is also active in certain somatic cells such as those in the epidermis but is almost undetectable in the dermis.
Telomerase is a rate limiting enzyme for cellular senescence , cancer and aging.
Telomerase is a ribonucleoprotein complex with a direct telomere protective function.
Telomerase is essential to maintain telomere length.
Telomerase is expressed in early human development and then becomes silenced in most normal tissues.
Telomerase is present in most human cancers , and proliferative stem cells including germline cells.
Telomerase is present in most human cancers , and proliferative stem cells including germline cells.
Telomerase is the ribonucleoprotein ( RNP ) reverse transcriptase responsible for synthesizing the @number@ ends of linear chromosomes.
Telomerase mutation carriers with emphysema report a family history of idiopathic pulmonary fibrosis , and both lung phenotypes show autosomal dominant inheritance within families.
Telomerase mutations and significantly shortened chromosomal telomeres have recently been implicated in human lung pathologies.
Telomerase plays an essential role in tumorigenesis by maintaining / elongating telomeric DNA , and thus preventing the telomere shortening that results in replicative senescence.
Telomerase plays an essential role in tumorigenesis by maintaining / elongating telomeric DNA , and thus preventing the telomere shortening that results in replicative senescence.
Telomerase plays a pivotal role in the pathology of aging and cancer by controlling telomere length and integrity.
Telomerase plays a pivotal role in the pathology of aging and cancer by maintaining genome integrity , controlling cell proliferation , and regulating tissue homeostasis.
Telomerases constitute a group of specialized ribonucleoprotein enzymes that remediate chromosomal shrinkage resulting from the \ "end-replication \ " problem.
Telomerase ( TERT ) is essential for telomere maintenance.
Telomerase , the reverse transcriptase capable of reconstituting shortened telomeres , is only minimally active in oocytes and preimplantation embryos.
Telomere and Telomerase have recently been explored as anti-aging and anti-cancer drug targets with only limited success.
Telomere-associated cellular senescence contributes to certain age-related cutaneous disorders , including increased cancer incidence.
Telomere assumes intra-molecular G-quadruplex that is a significant drug target for inhibiting telomerase maintenance of telomeres in cancer.
Telomere attrition is a natural process that occurs due to inadequate telomere maintenance.
Telomere attrition is associated with age-related LV diastolic dysfunction.
Telomere biology has recently emerged as an important player in the aging and disease process.
Telomere biology has recently emerged as an important player in the fields of ageing and disease.
Telomere composition changes during tumourigenesis , aging and in telomere syndromes in a poorly defined manner.
Telomere damage and reduced TPP1 dimerization as a result of Akt inhibition was also accompanied by diminished recruitment of TPP1 and POT1 to the telomeres.
Telomere deprotection occurs during tumorigenesis and aging upon telomere shortening or loss of the telomeric shelterin component TRF2.
Telomere DNA is related to cell aging and cancer genesis because the telomeric region of DNA sequences at chromosome ends are shortened with cell divisions.
Telomere dysfunction and genomic instability appear to be of critical importance for aging at a cellular level.
Telomere dysfunction has been linked to aging and cancer development.
Telomere dysfunction induced by TRF2 inhibition can accelerate cellular senescence in human fibroblasts.
Telomere dysfunction in WS is closely correlated with abnormality in tumorigenesis.
Telomere elongation by human telomerase is inhibited in cis by the telomeric protein TRF1 and its associated proteins.
Telomere elongation is carried out by telomerase.
Telomere erosion has been observed in psychiatric disorders including schizophrenia and mood disorders , suggesting an accelerated aging of @number@ to @number@ years.
Telomere erosion is a central component of aging , and telomere-associated proteins regulate cellular senescence and survival.
Telomere function is essential to maintaining the physical integrity of linear chromosomes and healthy human aging.
Telomere integrity will also be discussed in relation to aging and cognitive impairment , as well as , the micronutrients related to these events.
Telomere length , a highly heritable trait , is longer in offspring of older fathers.
Telomere length also did not correlate with any other haematological parameter in both men and women.
Telomere length and mitochondrial DNA ( mtDNA ) copy number were measured from leukocyte DNA by quantitative polymerase chain reaction.
Telomere length and mtDNA copy number were measured using quantitative polymerase chain reaction.
Telomere length and telomerase activity are important factors in the pathobiology of human diseases.
Telomere length and the rate of telomere attrition vary between individuals and have been interpreted as the rate at which individuals have aged.
Telomere length appears to be a biomarker of myocardial ageing.
Telomere length assessment is useful to predict organ transplantation outcome.
Telomere length at birth has been related to life expectancy.
Telomere length attrition has been demonstrated in schizophrenia but not in individuals in ultra high risk ( UHR ) for psychosis.
Telomere length can be considered as a biological marker for cell proliferation and aging.
Telomere length decreases with aging , and this contributes to cell senescence.
Telomere length has been associated with longevity.
Telomere length has been shown to be positively associated with nutritional status in human and animal studies.
Telomere length has emerged as a marker for biological ageing but it is unclear how telomere length relates to marital status.
Telomere length has emerged as a promising biomarker in studies that test the hypothesis that internalizing psychiatric disorders are associated with accumulating cellular damage.
Telomere length has garnered interest due to the potential role it may play as a biomarker for the cellular aging process.
Telomere length in adipocytes was shorter than in whole adipose tissue.
Telomere length in cancer was not associated with histological type , lesion location , or cancer stage.
Telomere length increased gradually with increasing UICC stage ( P = @number@ ) .
Telomere length in humans is emerging as a biomarker of aging because its shortening is associated with aging-related diseases and early mortality.
Telomere length in placental tissue and in buccal cells in young adulthood correlated positively ( r = @number@ P < @number@ ) .
Telomere length inversely correlated with lifespan , while telomerase expression co-evolved with body size.
Telomere length is a good indicator of the senescence of cells.
Telomere length is an important indicator of proliferative cell history and potential.
Telomere length is maximum at birth and decreases progressively with advancing age and thus is considered as a biomarker of chronological aging.
Telomere length is quantified by reduced telomere signal numbers and shorter chromosome @number@ telomeres measured in micrometers ( microns ) .
Telomere length is related to cellular aging and cardiovascular disease.
Telomere length of adipocytes but not whole adipose tissue correlated negatively with waist and adipocyte size , which was still significant after correction for age.
Telomere length of polar bodies predicts the fragmentation of human embryos.
Telomere length of whole adipose tissue associated negatively with fibrosis as determined by collagen content.
Telomere length shortening in subjects exposed to traffic exhausts and an increase in mitochondrial DNA copy number correlated to benzene exposure was also found.
Telomere lengths were determined using a multiplex qPCR assay.
Telomere length ( TL ) as a novel marker of cellular aging had a complex relationship to the MetS.
Telomere length ( TL ) is associated with an increased risk of aging-related diseases.
Telomere length ( TL ) shortening is a novel CVR marker , associated with inflammation biomarkers.
Telomere length ( TL ) was measured by QRT-PCR as abundance of telomere template versus a single gene copy encoding acidic ribosomal phosphoprotein P0.
Telomere length ( TL ) was quantified using qPCR in @number@ women from buccal specimens collected in @number@
Telomere length ( T / S ratio ) was measured using quantitative polymerase chain reaction.
Telomere length varies greatly among individuals of the same age , and is heritable.
Telomere length was analyzed in patients carrying telomerase gene mutations.
Telomere length was assessed using the quantitative polymerase chain reaction method.
Telomere length was available for a subset of participants in the @number@ wave ( n = @number@ ) .
Telomere length was correlated to perceived stress ( r = 0.77 ; p = 0.0001 ) but not to depression in our population.
Telomere length was determined from peripheral blood mononuclear cells of @number@ β-thalassemia / HbE patients and @number@ normal controls using Flow-FISH analysis.
Telomere length was determined using the Southern blot telomeric restriction fragment assay ( TRF ) .
Telomere length was determined with the use of monochrome multiplex quantitative real-time polymerase chain reaction in each placental tissue.
Telomere length was estimated at Wave @number@
Telomere length was measured as abundance of telomeric template versus a single gene by quantitative real-time polymerase chain reaction.
Telomere length was measured by restriction digestion - southern blotting technique.
Telomere length was measured using the telomere restriction fragment assay , gene expression was determined by rtPCR.
Telomere length was measured using the telomere restriction fragment assay , gene expression was determined by RT-PCR.
Telomere length was measured with qPCR and intracellular reactive oxygen species ( ROS ) content and cell death with flow cytometry.
Telomere length was not associated with any of the other measured cognitive , physical , or social traits.
Telomere length was shortened by PCB @number@ from day @number@ and PCB @number@ and CAM from days @number@ on.
Telomere length was significantly decreased in hCPC with slow-growth kinetics concomitant with decreased proliferation and upregulation of senescent markers compared with hCPC with fast-growth kinetics.
Telomere length was significantly shorter in placental samples from black mothers compared with white mothers.
Telomere length was significantly shorter in the @number@ formerly abused women compared to the @number@ controls ( t = @number@ p = @number@ ) .
Telomere loss limits the number of times cells can divide and is intimately involved in cell loss and renewal.
Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging.
Telomere maintenance is essential for protecting chromosome ends.
Telomere measurements obtained from blood-derived DNA are often used in epidemiological studies.
Telomere overhangs are essential for telomere end protection and telomerase extension , but how telomere overhangs are generated is unknown.
Telomere related diseases are also discussed in this review.
Telomere repeat amplification protocols showed a 2-fold increase of aortic telomerase activity in the pioglitazone group.
Telomere repeat copy number to single gene copy number ( T / S ) was determined by quantitative real-time PCR telomere assay.
Telomeres act as an internal clock , regulating the lifetime of the cell by their shortening during cell division.
Telomeres and mitochondria are known to deteriorate over time.
Telomeres and telomerase activity hold great promise for CKD risk stratification and personalized medicine.
Telomeres are a hotspot for sister chromatid exchange ( T-SCE ) .
Telomeres are a repeated sequence -of bases found at the ends of chromosomes.
Telomeres are DNA-protein structures that form protective caps at the end of eukaryotic chromosomes.
Telomeres are DNA sequences that cap the ends of chromosomes , protecting them from fraying and fusing together during replication.
Telomeres are dynamic chromosome-end structures that serve as guardians of genome stability.
Telomeres are ends of chromosomes that play an important part in the biology of eukaryotic cells.
Telomeres are ends of chromosomes that play an important part in the biology of eukaryotic cells.
Telomeres are essential for the integrity of chromosomes and for cellular replication.
Telomeres are essential in maintaining chromosome integrity and in controlling cellular replication.
Telomeres are gene sequences present at chromosomal ends and are responsible for maintaining genome integrity.
Telomeres are heterochromatic domains composed of repetitive DNA ( TTAGGG repeats ) bound to an array of specialized proteins.
Telomeres are important in aging processes and carcinogenesis.
Telomeres are known as the biological clock of the cell , since they shorten with each cell division.
Telomeres are located at each end of eukaryotic chromosomes.
Telomeres are longer in pluripotent stem cells than in somatic cells and lengthen significantly during preimplantation development.
Telomeres are long nucleotide repeats and protein complexes at the ends of chromosomes that are essential for maintaining chromosomal stability.
Telomeres are nucleo-protein complexes at the end of eukaryotic chromosomes.
Telomeres are nucleoprotein structures that cap the ends of eukaryotic chromosomes , protecting them from degradation and activation of DNA damage response.
Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic chromosomes , thus protecting their stability and integrity.
Telomeres are present at the ends of all eukaryotic chromosomes.
Telomeres are protective components that stabilize the ends of chromosomes and modulate cellular aging.
Telomeres are repetitive DNA sequences at the ends of chromatids that shorten following each cell replication.
Telomeres are repetitive DNA sequences at the ends of eukaryote chromosomes.
Telomeres are repetitive nucleotide sequences that together with the associated sheltrin complex protect the ends of chromosomes and maintain genomic stability.
Telomeres are repetitive sequences of DNA and associated proteins , which form a loop ( t loop ) at chromosome ends.
Telomeres are ribonucleoprotein structures capping the end of every linear chromosome.
Telomeres are short DNA repeats on the ends of mammalian chromosomes , which can undergo incomplete replication leading to gradual shortening with each cell cycle.
Telomeres are specialized DNA / protein structures essential for the maintenance of genome stability.
Telomeres are specialized DNA structures localized at the end of linear chromosomes.
Telomeres are specialized DNA structures , protecting the ends of linear chromosomes.
Telomeres are specialized nucleoprotein structures that protect chromosome ends from persistent DNA damage response activation.
Telomeres are specialized structures at the ends of eukaryotic chromosomes that are important for maintaining genome stability and integrity.
Telomeres are specialized structures at the ends of linear chromosomes that protect these ends from degradation and fusion.
Telomeres are structures that cap the ends of chromosomes.
Telomeres can be elongated by the enzyme telomerase , which adds de novo telomere repeats to the ends of chromosomes.
Telomeres consist of repetitive DNA-protein complexes that cap the ends of vertebrate linear chromosomes.
Telomeres constitute an attractive target for the development of novel small-molecule anti-cancer drugs.
Telomeres exhibit a paternal effect whereby the offspring of older fathers have longer telomeres due to increased telomere lengths of sperm with age.
Telomere shortening acts as a mitotic clock that prevents aberrant proliferation such as cancer.
Telomere shortening , a marker of cellular ageing , is linked with arterial stiffening.
Telomere shortening and an altered expression of the proto-oncogene c-FOS are among the key molecular mechanisms associated with photoaging and tumorigenesis.
Telomere shortening and chromosomal instability in the duct epithelium might be associated with carcinogenesis of the pancreas.
Telomere shortening and dysfunction results in cellular senescence , an irreversible proliferative arrest that has been suggested to promote organismal aging and disabling age-related diseases.
Telomere shortening and mitochondrial dysfunction are thought to be central to the cellular aging process.
Telomere shortening and telomerase deficiency have been linked with several age related degenerative diseases.
Telomere shortening causes reduced synapsis and chiasma , chromosome fusions , embryo arrest and fragmentation , and abnormal meiotic spindles.
Telomere shortening has been linked to cellular senescence and human aging , with oxidative stress as a major contributing factor.
Telomere shortening induces chromosomal instability that , in the absence of functional tumor suppressor genes , can contribute to tumorigenesis.
Telomere shortening in the kidney explains the impaired regenerative capacity , but may not drive the ageing phenotype itself.
Telomere shortening is a biomarker of aging.
Telomere shortening is a marker of aging and therefore telomere length might be related to disease progression and survival.
Telomere shortening is associated with aging , early senescence , and premature cell death.
Telomere shortening is associated with the risk of many aging-related diseases.
Telomere shortening is closely associated with severity of H. pylori-induced gastritis and CDH1 methylation status.
Telomere shortening is enhanced in HIV-infected patients because of HIV and some nucleoside analogue reverse transcriptase inhibitors.
Telomere shortening is found in blood leukocytes and alveolar epithelial cells from patients with IPF.
Telomere shortening is linked to hypertension , diabetes mellitus , and cardiovascular diseases.
Telomere shortening is proposed to be a primary molecular cause of aging.
Telomere shortening occurs concomitant with aging.
Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury.
Telomere shortening represents an established mechanism connecting aging and cancer development.
Telomere shortening represents lifetime exposure to oxidative stress and is negatively correlated with age , smoking , and mortality.
Telomere shortening was shown to parallel Alzheimer's disease ( AD ) associated dementia.
Telomeres in skin cells may be particularly susceptible to accelerated shortening because of both proliferation and DNA-damaging agents such as reactive oxygen species.
Telomeres , located at the end of linear chromosomes , are essential to maintain genomic stability.
Telomeres maintain chromosome stability and cell replicative capacity.
Telomeres of basal cells in the sun-exposed group were shorter than those in the sun-protected group.
Telomeres play a central role in cellular aging , and shorter telomere length has been associated with age-related disorders including diabetes.
Telomeres play a central role in cellular senescence and are associated with a variety of age-related disorders such as dementia , Alzheimer's disease and atherosclerosis.
Telomeres play a central role in human cancer , cardiovascular aging and possibly longevity.
Telomeres play a critical role in maintaining genome integrity.
Telomeres play an important role in cellular aging and cancer.
Telomeres play an important role in the maintenance of genomic stability / integrity and are synthesized by the RNA-dependent polymerase telomerase.
Telomeres prevent the blunt end of DNA from triggering a DNA damage response.
Telomeres protect chromosome ends against being recognized as double stranded DNA breaks , and are thought to be a guard against cancer.
Telomeres protect the chromosome ends from degradation and play crucial roles in cellular aging and disease.
Telomeres protect the chromosome ends from unscheduled DNA repair and degradation.
Telomeres protect the ends chromosomes from fusion with nearby chromosomes , and allow effective replication of DNA.
Telomeres protect the integrity of information-carrying DNA by serving as caps on the terminal portions of chromosomes.
Telomeres , regions of DNA that shorten with cell division , are considered reliable markers of biological aging.
Telomeres repress the DNA damage response at the natural chromosome ends to prevent cell-cycle arrest and maintain genome stability.
Telomeres shorten with age , and shorter leukocyte telomere length ( TL ) has been associated with overall mortality in numerous studies.
Telomeres shorten with each cell division and with increasing chronological age and short telomeres have been associated with a range of age-related diseases.
Telomeres shorten with each cell division eventually leading to cellular senescence.
Telomere stability is believed to be related to aging and tumorigenesis.
Telomeres , the DNA-protein structures located at the ends of chromosomes , have been proposed to act as a biomarker of aging.
Telomeres , the nucleotide repeats and protein complex at chromosome ends , are required for chromosomal stability and are important markers of aging.
Telomeres , the protective ends of linear chromosomes , shorten throughout an individual's lifetime.
Telomeres use distinct mechanisms ( not used by arms or centromeres ) to mediate cohesion between sister chromatids.
Telomeres were significantly longer in males than females ( p < @number@ ) .
Telomeric diseases are a group of rare progeroid genetic syndromes , presenting premature aging phenotypes , characterized for defects on telomere maintenance.
Telomeric DNA has been intensely investigated for its role in chromosome protection , aging , cell death , and disease.
Telomeric length is a reliable indicator of intrinsic biologic age and a surrogate for the mitotic clock.
Telomeric repeat amplification protocol ( TRAP ) is a fast and sensitive PCR-based assay for detection and measurement of telomerase activity.
Telomeric repeat binding factor @number@ ( TRF2 ) is essential for telomere maintenance and has been implicated in DNA damage response and aging.
Telomeric repeat binding factor @number@ ( TRF2 ) , which plays a central role in telomere capping , is frequently increased in human tumors.
Telomeric repeat containing RNAs ( TERRA ) are small RNA molecules synthesized from telomeric regions which were previously considered as silent genomic domains.
Telomeric repeat-containing RNA ( TERRA ) , which is transcribed from telomeres , emerged as important player in telomere integrity.
Telomeric termini are processed in two distinct phases.
TEM observation showed a demineralized layer and an amorphous gel phase in the polyalkenoic acid conditioned group.
Temperature is a basic and essential property of any physical system , including living systems.
Temperature-related changes in cerebral vascular function may play a role , but this hypothesis has not been previously evaluated.
Temporal analysis of these data revealed cascades of modules that are dynamically activated within and across species.
Temporal and correlative associations between TBARS and 8-OHdG were explored.
Temporal autocorrelation was not significantly associated with frailty.
Temporal change is one source of within-person variation in DNA methylation that has been linked to aging and disease.
Temporal changes in their demographics , the mode of treatment , and outcomes including mortality were analysed.
Temporal correlations between spatially distinct regions were evaluated by using longitudinal resting-state fMRI.
Temporal discounting ( TD ) matures with age , alongside other markers of increased impulse control , and coherent , self-regulated behaviour.
Temporal Gait measures were collected on a GAITRite walkway and gait variability was determined by calculating intraindividual standard deviations.
Temporal patterns of quiescent electromyography termed ' gaps ' were investigated in young and old men and women for a discrete task and daily activity.
Temporal processing can be evaluated using gap detection procedures.
Temporal processing was relatively resistant to subjects ' hearing status , but it depended on cognitive competence.
Temporal segmentation , independent of the cultural level , revealed the best acquired knowledge in our control population.
Temporal sequencing influences of AUDs and CUDs on each other were similar in youth and adulthood but not young adulthood.
Temporal trends in adherence and viral load suppression were examined by the patient's most frequently used HAART regimen in the year.
Temporary restorations were fixed on enamel and CIE L a b colour parameters of each specimen were assessed before and after artificial accelerated aging.
Temporary weakness in the branches of the facial nerve experienced by two patients resolved completely within some months.
Temporospatial principal component analysis ( PCA ) was used to identify underlying components that may be obscured by overlapping ERP waveforms.
TEM showed swollen mitochondria with degraded cristae , loss of membrane , loss of Golgi bodies , degenerated nerves , and disrupted cell-to-cell junctions.
Ten 30-min music sessions occurred in which participants engaged in singing , structured conversation , moving to music , and instrument playing interventions.
Ten articles reported positive staff , patient and volunteer feedback.
Ten cerebella from elderly female subjects with severe Alzheimer's disease and @number@ age- and gender-matched controls were examined.
Ten databases were used.
Tendency for a lesser increase of the browning potential index values was detected for white wines aged in new oak wood barrels.
Tender cuts were cooked by a dry heat method , and less tender cuts were cooked by moist heat methods.
Tenderness of primal cuts from the same carcass varied considerably , with collagen content and shear force resistance as the largest discriminants between the cuts.
Tenderness , residue and collagen solubility of all cuts decreased significantly with animal age.
Ten different transcripts for GFAP isoforms were detected at different abundancies.
Tendon collagen fibrillar area tended to be higher in GHD patients relative to ACRO patients ( P = 0.07 ) .
Tendon-derived stem cells ( TDSCs ) are multipotent adult stem cells with potential applications in tendon and tendon-bone junction repair.
Tendon-like tissue formed in vivo consisted of parallel collagen fibres typical of tendon tissues.
Tendons treated with hASCs showed better gross morphological and biomechanical recovery than those in the fibrin and sham groups.
Tendon thickness has a linear relationship with age ; however cartilage thickness varies across sites and also differs as a function of gender.
Tendon thickness was not significantly influenced by gender.
Tendon vascularity was only present in young children ( group @number@ ) , in @date@ ( @percent@ ) quadriceps tendons.
Ten elderly individuals were exposed to external predictable and unpredictable perturbations applied to the upper body in the sagittal plane.
Ten eligible studies were identified.
Ten employees who had contact with the students , clients , and family were interviewed using a semistructured interview method.
Ten female sibship cohorts , each consisting of three individuals , were allocated to one of three groups.
Ten frail aged adults ( frail group [ FG ] ) and ten young subjects ( young group [ YG ] ) performed the TUG.
Ten health care providers ( nurse , physiotherapists , and occupational therapists ) were interviewed and data was analysed.
Ten healthy elderly subjects were enrolled as a control group.
Ten healthy older adults and thirteen healthy young adults were exposed to predictable external perturbations using the pendulum impact paradigm.
Ten healthy older adults were tested with the previous protocol and compared with the previously-tested young adults.
Ten healthy participants were recruited in @number@ groups ; young : 20-33 years , Older1 : 65-74 years , Older2 : 75-85 years.
Ten healthy young adults ( @number@.5±2.5 years ) and ten healthy older adults ( @number@.5±2.9 years ) participated in the study.
Ten individuals were selected through purposive sampling and tested using a single group pretest-posttest design.
Ten instrumented standing balance measures and @number@ instrumented TUG measures were computed from the wireless sensor data.
Ten male transgenic mice ( αMHC ( @number@ ) ) were examined at ages @number@ weeks , @number@ weeks , and @number@ weeks.
Ten-month-olds ( n = @number@ ) and adults ( n = @number@ ) anticipate SP spoons ; however , only adults anticipate combing actions.
Ten muscles were tested in vitro.
Ten novel lipid-related CpG sites annotated to various genes including ABCG1 , MIR33B / SREBF1 , and TNIP1 were identified.
Ten nurses rated the perceived age of the twin from the original and swapped facial images.
Ten of @number@ items in which kappa could be calculated had at least fair agreement.
Ten of these sets of target genes are significantly enriched for microRNA targets ( FDR < @percent@ ) .
Ten of the wheelchair users also participated in individual semi-structured interviews exploring their perceptions regarding how sports-related experiences affected their quality of life.
Ten older ( 5M / 5W ; > 60years old ) and nineteen height-matched young adults ( 10M / 9W ) were recruited.
Ten out of @number@ articles found BMD was significantly lower in patients with PKU.
Ten participants had suffered from pain for @number@ years or more.
Ten patients had a history of myocardial infarct , @number@ cerebrovascular accident , and @number@ various tumors.
Ten patients had minor wound breakdown , which healed with conservative wound care.
Ten patients had serial MRI of the same anatomic region for more than @number@ years of clinical follow-up.
Ten patients of @number@ years old or older were shadowed from admission until discharge.
Ten patients ( @percent@ ) reached end-stage kidney disease ( ESKD ) at ages ranging from 37-69-yo ( mean @number@ , 1-yo ) .
Ten patients underwent surgery because of an incomplete resection and / or histological evaluation.
Ten percent to @percent@ of all human transmissible spongiform encephalopathy are characterized by a mutation in prion protein gene ( PRNP ) .
Ten residents ( @number@ female ; @number@ ± @number@ years ) participated in @date@ / week Seated Qigong sessions for 10-weeks.
Ten samples , @number@ × @number@ × @number@ mm3 , from each silicone were made and stored in sealed glass containers in the dark.
Tense feelings and worrying especially need more attention , because more than one-half of all older people with ID reported such symptoms.
Tensile bond strength testing was performed at a crosshead speed of @number@ mm / min and permanent deformation with a compressive load of @number@ gf.
Tensile tests up to rupture are carried out to evaluate the influence of age and wall anisotropy.
Tension-type headache ( TTH ) is the most prevalent headache type in all age groups worldwide , including patients with advanced age.
Ten SNPs in four haploblocks showed significant association with IGF-1 levels , with p = @number@ @date@ .
Tens of thousands of women treated for cancer each year experience infertility and early menopause as a result of treatment.
Tensor-based morphometry methods were used to evaluate volume change over time.
Tensors were calculated to obtain fractional anisotropy ( FA ) and mean diffusivity ( MD ) maps.
Ten sound human molars were sectioned and silicon carbide-polished to obtain enamel and dentin slabs @number@ mm in thickness.
Ten specimens were built using a @number@ mm thick increment of dentin composite overlapped by a @number@ mm thick increment of enamel composite.
Ten studies met all inclusion criteria.
Ten studies observed a positive association between early AFB and CVD while two studies observed a positive association between later AFB and CVD.
Ten subjects in each group completed the study.
Ten subjects presented GH peak of less than @number@ microg / L after GST , none confirmed in ITT.
Ten subjects underwent an additional [ ( @number@ ) C ] PiB PET scan within @number@ weeks.
Tentative evidence was found for BC and OE predicting AA / AR , as well as for AA / AR predicting FOF.
Tentative evidence was found for FSe predicting depression.
Tentative evidence was found for FSe predicting QoL.
Ten trials were collected in one session.
Ten trials were included.
Tenuigenin could provide a novel antioxidative strategy for Parkinson's disease.
Tenure-related increases in psychosocial exposure levels may help explain the CO symptom increase.
Ten-year mortality data were obtained through the National Registry Department.
Ten years ago we first proposed the Alzheimer's disease ( AD ) mitochondrial cascade hypothesis.
Ten years later , some have been answered , including confirmation that HT for most newly menopausal women is safe and effective.
Ten years later ( t₁₀ ) , the screening was repeated in @number@ subjects who were non-diabetic at t₀ ( @percent@ of survivors ) .
Ten young and @number@ elderly healthy subjects were assessed using gait analysis while walking at comparable speed.
Ten young and @number@ older healthy volunteers took part in this study.
Ten young subjects ( @number@ ± @number@ years ) and ten subjects aged over @number@ years ( @number@ ± @number@ ) participated in the study.
Teriparatide ( @number@ µg daily subcutaneous ) ( TPD ) was used as an open label active comparator.
Terminal Restriction Fragment analysis was additionally performed in a sub-sample to obtain absolute LTL in base pairs.
Terminal Restriction Fragment analysis was additionally performed in a subsample to obtain absolute TL in base pairs.
Terminology and definitions for imaging the features of SVD vary widely , which is also true for protocols for image acquisition and image analysis.
Terms for total daily physical activity and its interaction with WMH volume were then added to the model.
TERRA abundance is highly dependent on developmental status ( including nuclear reprogramming ) , telomere length , cellular stresses , tumour stage and chromatin structure.
TERRA has been involved in the regulation of telomere length , telomerase activity , and heterochromatin formation at telomeres.
Tert-butanol-based XP Bond showed excellent marginal adaptation in both enamel and dentin.
TERT gene was successfully transfected into normal HCECs.
TERT-HCECs formed a monolayer cell sheet , maintained similar cell junction formation and pump function with primary HCECs.
Tertiary outcomes included global and executive cognitive function and incident MCI or dementia at @number@ months.
Tertile analyses tended towards a protective association , but most did not achieve statistical significance ; there was no dose-response.
TERT mutation status is more accurately predicted by short telomere lengths than any of these measured phenotypes.
Test bias against African Americans has been documented in both cognitive aging and early life span studies.
Test characteristics of item two of the CSI ( suicidal thoughts ) and MINI were compared.
Test data was used to build classification models for a Pass or Fail score on an on-road driving assessment.
Tested by random effect model and sensitivity analysis , the pooled results show nice robustness.
Testicular glucose metabolism increases until age @number@ years , after which it declines gradually over time at a constant rate.
Testicular nuclear receptor @number@ ( TR4 ) , a member of the nuclear receptor superfamily , plays important roles in metabolism , fertility and aging.
Testicular nuclear receptor @number@ ( TR4 ) plays protective roles against oxidative stress and DNA damage and might contribute to aging.
Testicular samples derived from @number@ young men were used for control.
Testicular volume rapidly increases during puberty and peaks at age @number@ years.
Testing effective pharmacological treatment of human heart failure requires a suitable animal model that adequately mimics the human disease state.
Testing for association between TL and rs2293607 was performed using linear regression models or variance component analysis conditioning on relatedness among subjects.
Testing for executive dysfunction may help identify individuals at risk for stroke in time to prevent them.
Testing for the indirect effect is challenged by the fact that the null hypothesis is composite.
Testing included @number@ candidate and established risk genes.
Testing infants at @number@ @number@ and @number@ months of age , we hypothesized that different age groups are differentially sensitive to accentuation and repetition.
Testing @number@ participants , we demonstrated that independent hints relating to the initial search space and to representational change had little effect on solution rates.
Testing of this grading was made on the basis of the Scientific and Methodological Gerontological Center.
Testing older adults in the morning generally improves behavioral performance relative to afternoon testing.
Testing one's memory of previously studied information reduces the rate of forgetting , compared to restudy.
Testing only for BRCA1 / 2 would miss in our series more than @percent@ of the patients with a deleterious variant in established risk genes.
Testing the interaction between IL-6 and GSTM1 genotype , we found a significant result ( p = 0.02 ) .
Testing viability effects of sets of genetic variants that jointly influence @number@ of @number@ traits , we detected a number of strong signals.
Testing was binocular with habitual near correction.
Testing was conducted on two occasions , one week apart.
Testing was performed before a control period of @number@ d , as well as before and after @number@ d of RIF.
Test items were words that corresponded to studied words or the names of studied objects.
Test @number@ and @number@ were always taken individually , and Test @number@ was done either in triads or alone.
Testosterone administration has been shown to stimulate GH secretion.
Testosterone administration was also associated with an improvement in body composition.
Testosterone and bioavailable testosterone levels at @number@ months were @number@ ng / dL and @number@ ng / dL , respectively , in the treatment group.
Testosterone and dihydrotestosterone may also relax penile artery and cavernous smooth muscle through their nongenomic effects.
Testosterone and E2 levels were measured by liquid and gas chromatography / mass spectrometry , respectively.
Testosterone and growth hormone improve muscle mass and muscle strength , but have several side effects.
Testosterone and leg bone mineral content were negatively associated with adiponectin in females ( P < @number@ ) .
Testosterone and TL data were available on @number@ individuals.
Testosterone appears to have a biphasic effect on gonadotropin production in females.
Testosterone causes water retention and oedema is common in older persons.
Testosterone decreases angina and may improve the cardiac healing response after myocardial infarction.
Testosterone deficiency afflicts approximately @percent@ of men ages 40-79 years.
Testosterone deficiency can occur in males of all ages.
Testosterone deficiency syndrome ( TDS ) has received widespread attention in the last several years.
Testosterone deficiency ( TD ) is defined as a serum level less than @number@ ng / dL on a morning total testosterone test.
Testosterone dosing was adjusted to a serum testosterone of @number@ to @number@ ng / dl.
Testosterone enhances function in males with heart failure ( HF ) .
Testosterone had little effect , implying it is not an intermediate.
Testosterone has now become one of the most widely used medications throughout the world.
Testosterone is implicated in regulating metabolic functions , maintenance of muscle and bone , and inhibition of adipogenesis.
Testosterone is one of the most potent naturally secreted androgenic-anabolic hormones , and its biological effects include promotion of muscle growth.
Testosterone levels are not unequivocally low and associated symptoms are non-specific.
Testosterone levels exhibit a circadian rhythm in healthy men , with morning levels tending to be higher compared to evening titers.
Testosterone levels were lower in men from the AUE group compared with non-anaemic controls.
Testosterone pellets were well tolerated.
Testosterone preserved the integrity of neurites and the expression of presynaptic proteins.
Testosterone provides dual action in breast tissues , stimulation with being converted into estrogen and suppressant effect as testosterone.
Testosterone replacement has therefore been suggested as a possible intervention to treat frailty.
Testosterone replacement in deficient men with such co-morbidities ameliorates or partially reverses their progression.
Testosterone replacement is being increasingly offered to older men with age-related low testosterone.
Testosterone replacements in orchidectomised rats were able to prevent the rise of CTX.
Testosterone replacement therapy is effective in treating hypogonadism.
Testosterone replacement therapy is only warranted in the presence of both clinical symptoms suggesting hormone deficiency and decreased hormone levels.
Testosterone replacement therapy provides significant symptomatic improvements for men with late start hypogonadism.
Testosterone's effects on physical activity were mediated through a different pathway because testosterone directly affected Physical Activity Score of the Elderly.
Testosterone's promyogenic effects are mediated through upregulation of follistatin.
Testosterone supplementation therapy ( TST ) is the standard treatment for male hypogonadism.
Testosterone ( T ) is a biologically important androgen that demonstrates a widely-known natural decline with advancing age.
Testosterone treatment did not have any significant effect on plasma levels of FGF23 or soluble Klotho.
Testosterone treatment increased spine areal BMD but less than vBMD.
Testosterone treatment in frail older men with limited mobility and with testosterone deficiency improved insulin resistance , glucose metabolism , and body composition.
Testosterone treatment resulted in a hemoglobin concentration of more than @number@ g / dL in @number@ men who had not been anemic at baseline.
Testosterone ( T ) replacement is being increasingly offered to older men with age-related decline in testosterone levels.
Testosterone was highly age dependent , and most putative symptoms of TDS showed significant age dependence but was not affected by serum testosterone levels.
Testosterone was monitored before treatment , @number@ weeks and after @number@ weeks.
Testosterone was not significantly correlated with global cognitive function or executive function in either gender.
Test results indicated that he was , with a few exceptions , neuropsychologically normal.
Test-retest data for cortical areas showed good to moderate reproducibility ( @percent@ to @percent@ ) .
Test-retest data with a 1-year interval were used to estimate reliability coefficients and to calculate Reliable Change indices useful for evaluating persons with suspected dementia.
Test-retest intraclass correlation was @number@
Test-retest photographic evaluations demonstrated that both interrater and intrarater reliability were adequate for primary study outcomes.
Test-retest reliabilities for the FTSTS and TUG tests were high ( intraclass correlation coefficient = @number@.89-0.94 ) for the VU + and VU-.
Test-retest reliability and internal consistency were calculated by intraclass correlation coefficient ( ICC ) and Cronbach's coefficient α , respectively.
Test-retest reliability for the EPU was r = @number@ R = @number@
Test-retest reliability of the fMRI blood oxygen level dependent ( BOLD ) activity was assessed using an intraclass correlation ( ICC ) analysis approach.
Test-retest reliability of the @number@.5- and @number@.0-kg SMBT was r = @number@ and r = @number@ respectively.
Test-retest reliability was assessed in @number@ children.
Test-retest reliability was assessed using intraclass correlation coefficients ( ICCs ) .
Test-retest reliability was assessed using the intraclass correlation coefficient ( ICC ) .
Test-retest reliability was at least fair to good for adults and adolescents , but poor to fair for the youngest age group.
Test-retest variation is relatively large and tends to decrease with increasing age in both men and women.
Test-retest was carried out to test the instrument's stability.
Tests about tears and fissures showed inconsistent results , as well as for disc collapse and dehydration.
Tests assessed locomotion , strength , balance / coordination , and endurance capacity in mice.
Tests between apoE polymorphisms with other clinical / biochemical variables and those with arterial calcification showed no significant differences between groups.
Tests evaluating other cognitive functions were not affected by use of drugs with anticholinergic activity.
Tests included verbal associative and logical memory and memory in executive and object recognition domains.
Tests of aerobic capacity and muscle function were performed and anthropometric data were collected.
Tests of attention , executive function , processing speed and memory were performed to assess actual cognitive function.
Tests of famous faces are used to study language and memory.
Tests of moderation by demographic characteristics and level of ICT use were also performed.
Tests of physical performance are now routinely included in longitudinal studies to measure functional limitations , which are considered the building blocks of functioning.
Tests of proverb interpretation , additional executive functions , and functional ability were administered to nondemented older adults.
Tests on @number@ healthy male subjects showed the apparatus located the epigastric region with a success rate of @percent@.
Test-specific statistical regression-weights for age , education and gender were calculated to establish preliminary test norms.
Tests to detect suboptimal effort are becoming widely used in clinical practice and are based on their reported insensitivity to cognitive dysfunction.
Tests were administered at baseline , @number@ months , and @number@ months.
Tests were quantified using shank-mounted inertial sensors.
Tests were repeated after @number@ days to determine any long-term effects.
Tests were repeated at @number@ @number@ @number@ @number@ and @number@ days after initial examination.
Tests with proteasomal and macroautophagy inhibitors further demonstrate that RER1 effects on αSyn are primarily mediated through the ubiquitin-proteasome system.
TET2 gene mutations similar to those observed in myeloid and lymphoid malignancies also accumulate with age in otherwise healthy subjects with clonal hematopoiesis.
TET2 has pleiotropic roles during hematopoiesis , including stem-cell self-renewal , lineage commitment and terminal differentiation of monocytes.
TET2 is the most expressed TET gene in the hematopoietic tissue , especially in hematopoietic stem cells.
TET dioxygenases require 2-oxoglutarate , oxygen and Fe ( II ) for their activity , which is enhanced in the presence of ascorbic acid.
Tetracycline hydrochloride was administered orally @number@ and 3days prior to sacrifice for determination of active mineralization sites.
Tetravalent dengue vaccine is currently being tested in clinical trials.
TEWL gradually improved , although without statistical significance.
TEWL was systematically increased after pH and systematically decreased after stratum corneum measurements.
Text-based representations of models are precise descriptions , but hard to understand and interpret.
Text processing , which analyzes free-text fields through automated methods , can facilitate this process.
Textual and visual representations of age are instructive as they suggest ideals towards which individuals should strive and influence how we perceive age.
Texture and bioadhesion assay showed that formulation B is suitable for topical application.
Texture and color were also evaluated via an instrumental method.
Texture defects described in the literature are contradictory.
TF expression level correlated with age in both wild-type and DKO mice.
TF motifs in promoter regions of trimmed sets of target genes were scanned using JASPAR and TRANSFAC.
TFPI release was measured prior to ( baseline ) and at @number@ @number@ @number@ and @number@ min post-UFH dose.
Tf protects hepatocytes against Fas-induced cell death by reducing BID cleavage , inhibiting caspase-3 and @number@ activation and up-regulating survival signals such as Bcl-xL.
TF protein expression was also enhanced in human AMD maculae.
TF signatures established a global mapping of agglomerating motifs with distinct clusters when ranked hierarchically.
TFS sensitivity was not correlated with absolute sensitivity at the test frequency.
TFTs were performed at hospital admission , and mortality was registered in the follow-up period.
TG activity increases with age in many circumstances.
TG and apoC-III co-accumulated with LDL , high density lipoprotein ( HDL ) 2 , and HDL3 in the MetS group.
Tg-ArcSwe mice express variants of Aβ , accumulating senile plaques at 4-6 months of age , and develop AD-like neuropathology as adult animals.
TGase-1 enzyme expression was upregulated @number@ ± @number@ times in the matrix gel-treated skin.
TGDS ( dTDP-D-glucose @number@ , 6-dehydrogenase ) is a conserved protein belonging to the SDR family and probably plays a role in nucleotide sugar metabolism.
TGF-β1 inhibited the cellular growth and migration of follicular ( FTC-133 ) and papillary ( B-CPAP ) thyroid carcinoma cell lines.
TGF-β1 is known to modulate several stromal responses ; however there are few transgenic models to study its integrated biology.
TGF-β1 is overexpressed in wound repair and in most proliferative disorders including benign prostatic hyperplasia and prostate cancer.
TGF-β1 , TβRII and EGFR expressions were evaluated in benign and malignant thyroid tumors.
TGF-β1 was a negative determinative factor for BAP , OC , sCTX and uCTX , which could explain @number@.7-7.3% of the variation in these markers.
TGFβ2 was found to downregulate the expression of the CITED2 gene and knockdown of CITED2 abolished the effect of TGFβ2 on TDSC proliferation and senescence.
TGF-β activity regulates reproductive span and germline / oocyte quality noncell-autonomously and is temporally and transcriptionally separable from its regulation of growth.
TGF-β-loaded EMTs ( EMT ( + TGF ) ) facilitate cartilaginous tissue formation during culture in media not supplemented with the growth factor.
TGFβ signalling is induced by loading and has an important function in maintaining the differentiated phenotype of articular chondrocytes.
Tg mice exhibited neuronal degeneration and neuronal decline.
TG performed an 8-week resistance training program , while CG followed their daily routines.
TG performed an 8-week resistance training program , while CG followed their daily routines.
Th17 cells produce IL-17 that plays an important role in host defense.
T had no univariate effect but was a positive correlate of ACTH when assessed jointly with E2 ( negative ) under cortisol pulses.
Thalamic CDR DT MRI abnormalities were correlated with abnormalities of the corresponding cortico-thalamic tracts.
Thalamic connectivity defined regions ( CDRs ) were segmented based on their cortical connectivity using diffusion tractography-based parcellation.
Thalamic diffusion differences are related to lower cognitive function only in participants with high-grade DWMHs.
Thalamic reliability was also very good , with VAR of @percent@ and ICC of @number@
Thal phase and VGLUT1 did not distinguish the cognitive impairment and dementia groups.
Thal phase , Braak stage , cerebrovascular disease , hippocampal sclerosis and Pathological 43-kDa transactive response sequence DNA-binding protein ( TDP-43 ) were also analysed.
Thanks to early treatment initiation , children with phenylketonuria are able to lead life to the full.
Thanks to good storage conditions , it was possible to analyze their original characteristics.
Thanks to major randomized studies such as the PARTNER US trial , this treatment has been approved for high-risk patients.
Thanks to the generative nature of the scheme , the segmentation method is robust to changes in MRI contrast or acquisition hardware.
Thanks to their high antioxidant activity , caffeic and p-coumaric acids were identified as the major antioxidant components.
Thanks to treatment advances , people with HIV can and do live long and full lives.
That Alzheimer's disease ( AD ) might be a human-specific disease was hypothesized by Rapoport in @number@
That can be considered as elevated risks for dysadaptation in those individuals under extra functional exercises.
That decrements were not attenuated for positive emotions indicates that they cannot be explained by a positivity effect in older adults.
That includes Parkinson's disease and Alzheimer's disease.
That is , a high level of mutuality and preparedness protected caregivers from high levels of role strain , even when caregiving demand was high.
That is , as the duration increased , the acoustic reflex threshold for the @number@ Hz tonal activator decreased.
That is , cognitive aging does not spell doom for financial decision-making in domains where the decision maker has developed expertise.
That is , dysfunctional state and national systems should be boldly marked for demolition.
That is , for every year increase in age , AUC increases by approximately @number@ mg·h / liter.
That is , generative concern is partly associated with meaning in life because it leads to generative goals.
That is , individuals with lower control beliefs made more errors as confidence decreased.
That is , nesprins are implicated in diseases such as cancer , myopathies , arthrogryposis , neurological disorders and hearing loss.
That is , poorer-strategy effects were smaller on current problems after using a poorer strategy on preceding problems than after using a better strategy.
That is , reshaping can add @number@ to @number@ diopters of accommodation.
That is , SD is associated with a generalized somatosensory deficit.
That is , that group perceived greater postural demands with the standing posture and elected to program a more conservative strategy , resulting in underestimation.
That is , the disease was also rare in developed countries , until the 20th century.
That is , which factors and processes characterize successful aging both on a system and on a molecular level ?
That is , while osteoporosis tends to occur in postmenopausal women , the decrease in skeletal muscle is more likely to occur in men.
That is , while the motor deficits in focal dystonia are confined , the associated somatosensory deficits are generalized.
That many older individuals continue to engage in various forms of sexual expression well into later life is now well established in the literature.
That number is expected to rise to @number@ billion by @number@ or to @percent@ of the overall population.
That paper's principal data set , the ED01 records , was scrambled when read and analyzed with a statistical software package.
That prescription would require either a re-allocation of resources ( incomes ) away from politically well-entrenched interests , or simply more money.
That prevalence rate is expected to triple as the population ages.
That process is called chronologic or intrinsic aging.
That program was modified with examples and exercises targeted to an older population and evaluated in the current single-arm pilot study.
That reduces osteoblastogenesis , thus favoring bone-mass loss and fracture , representing an important worldwide health-issue , mainly in countries with aging populations.
That RPE associated to its corresponding load was subjected to a linear regression analysis to extrapolate the maximal RPE score and its corresponding 1-RM.
That some aging-associated phenotypes may be reversible is an emerging theme in contemporary aging research.
\ "That's opposite to what we typically think , \ " he remarks , looking back on the incident.
That the association increased with parents ' age and was somewhat stronger for the non-married may suggest that social support is a possible explanation.
That the gender gap in aging is attributable to androgens appears more likely given a recent report of exceptional longevity in eunuchs.
THC was safe and well tolerated.
The 0N isoform is mainly found in cell bodies and axons , whereas nuclei and dendrites are only slightly stained with the 0N antibody.
The 10-item Center for Epidemiological Studies Depression Scale was the outcome measure.
The 10-point ( @number@ to @number@ ) MedDiet Score was used to categorize adherence to MedDiet.
The 10-year fracture prediction was established , using the FRAX calculator and Garvan nomogram.
The 10-year median survival probability based on their comorbidities and age was more than @percent@.
The 10-year overall prosthetic survival rate using revision as the end point was @percent@.
The 10-year predicted coronary CS was based on the mathematical formula derived by the Heinz Nixdorf Recall Study.
The 11-repeat allele was human specific and the sole allele detected in @number@ unrelated Iranian individuals randomly selected and sequenced from our control pool.
The 12-19 y.o. and 20-39 y.o. groups had a delayed sleep schedule and acrophase compared to all other groups.
The 12-kb haplotype is a risk factor for metabolic syndrome and insulin resistance that needs to be explored in further populations.
The 13-item Orientation to Life Questionnaire ( OLQ-13 ) can be used to measure Sense of Coherence.
The 1410-nm wavelength is optimal for superficial dermal treatments up to @number@ μm deep.
The 15-year incidence for definite hypothyroidism remains low and subclinical hypothyroidism is not a precursor for the onset of definite hypothyroidism.
The 16-week intervention included progressive and challenging balance , gait , and strength exercise as well as changes to behavioral aspects.
The 17-item Hamilton Rating Scale for Depression ( HRSD17 ) was used to measure efficacy.
The 17-item Philadelphia Geriatric Center Morale Scale ( PGCMS ) was used to assess morale.
The 18-month cohort comprised @number@ HCs , @number@ MCI cases , @number@ AD patients , and one Parkinson's disease dementia case.
The 1KJPN was effective for imputing genotypes of the Japanese population genome wide.
The 1RM prediction equations were developed by multiple regression analyses.
The 1-year adverse outcomes were correlated with mFI , patients ' and procedure's risk factors.
The 1-year all-cause mortality was @percent@ among patients who received their first HF diagnosis during a hospitalization in @number@
The 1-year mortality of patients was @number@ and @time@ % ( P < @number@ ) in men and women , respectively.
The 1-year mortality rate was @percent@ , with no significant difference between cardiovascular ( @percent@ ) and noncardiovascular ( @percent@ ) deaths.
The 1-year rate of ischemic stroke decreased from @percent@ ( @percent@ CI @number@.3%-3.4% ) to @percent@ ( @number@.5%-2.7% ; P < @number@ ) .
The 2006-2011 incidence rate was @number@ per @number@ person-years , much higher among females and persons born in the Isle of Man.
The 2010 / 2011 influenza vaccine has been adapted and includes the pandemic influenza H1N1 @number@ strain.
The 20-item Center for Epidemiologic Studies Depression Scale was used to measure depressive symptoms.
The 20-m shuttle run , handgrip strength , and standing long jump tests were used to assess physical fitness.
The 23-valent polysaccharide pneumococcal vaccine has been discussed critically.
The 29-item Menopause-Specific Quality of Life Questionnaire was used to assess vasomotor , psychosocial , physical , and sexual symptoms related to menopause.
The 2-day workshop combined KT theory presentations with small group activities to prioritize topics using a modified Delphi method.
The 2N isoform that was undetectable at P0 , in adult brain was mainly found localized to cell bodies and dendrites.
The 2-year combined events rate was significantly lower in reversible MD ( log-rank test P = @number@ ) compared with sustained MD patients.
The 2-year follow-up outcomes examined were all-cause mortality , disability , hospitalisation and falls.
The 30-day all-cause readmission rate and discharge disposition remained stable.
The 30-day mortality rates of community-acquired pneumonia ( CAP ) and nursing home-acquired pneumonia ( NHAP ) were @percent@ and @percent@ respectively.
The 30-item mini-mental state examination ( MMSE ) was used to assess cognitive function.
The 30-s sit-to-stand test was evaluated as a functional capacity parameter.
The 30-year survival rate after MI was poor for the patients with a low LVEF.
The 32-channel coil generally outperformed the 12-channel coil , with more benefit for MP2RAGE.
The 3- , 5- , and 7-year survival rates were @percent@ , @percent@ , and @percent@ , respectively.
The 36-item short-form survey was administered to assess HRQOL.
The 39-item Parkinson's disease Questionnaire ( PDQ-39 ) is the most widely used PD-specific health-related quality-of-life questionnaire.
The 3-BSRS-subitem sum score correlated with suicidal ideation.
The 3D-CAM delirium diagnosis was compared with the reference standard in all patients and subgroups with and without dementia.
The 3D environment of the anatomical structures contained in the MTL is an important issue.
The 3D model of pathological and MRI residual tumors was reconstructed with 3D-DOCTOR software.
The 3D volumetric method had favorable intra-observer and inter-observer agreement.
The 3- ( @number@ , 5-Dimethylthiazol-2-yl ) -2 , 5-diphenyltetrazolium bromide ( MTT ) assay was used to assess cell viability.
The 3T MRI using NeuroQuant has an increased resolution @number@ times that of @number@.5T MRI.
The 3xTgAD adaptive response was to substantially increase monocarboxylate transporters in neurons while decreasing their expression at the BBB and in astrocytes.
The 3xtg AD model likely has the highest face and construct validity but further studies are needed.
The 3-year-olds exhibited a strong yes bias for both objects , and their response latency was significantly shorter than that of the 6-year-olds.
The 3-year overall failure risk ratio was @number@ [ @number@.38- @time@ ] in favor of ceramic inlays although not statistically significant.
The 40-min soccer sessions were held @number@ times per week for @number@ weeks.
The €4 allele of the apolipoprotein E ( apoE ) gene is associated with dementia and unfavorable outcome following brain insult.
The 5b ( 3b ) 3b MOLLI scheme offered comparable native T1 measurement accuracy and precision to conventional MOLLI , despite its shortened acquisition.
The 5th centile for percentage recovery of SYSBP was @percent@.
The 5XFAD mice may serve as a useful model for testing therapeutic strategies to improve sleep consolidation in AD patients.
The 5-year DFS and OS rates were @percent@ and @percent@ , respectively.
The 5-year DSS rate was significantly lower in older patients ( @percent@ ) .
The 5-year overall survival ( OS ) in patients ≥ @number@ years old with acute myeloid leukemia ( AML ) remains < @percent@.
The 5-year survival rate of the overall patients was @percent@ ± @percent@.
The ≥65 year olds living in rental or leasehold retirement villages may require extra assistance / resources to adhere to their medicines.
The 6CIT was administered by general practitioners ( GPs ) at routine examinations every two years.
The 6-Day Sample ( N = @number@ ) were rated on six personality characteristics by their teachers at around age @number@
The 6-minute walk distance ( 6MWD ) test for functional capacity assessment , may be time-consuming and burdensome.
The 6-month cognitive change was examined with the Mini-Mental State Examination ( MMSE ) score in the @number@ groups according to the use of memantine.
The 6-month-long ADF diet resulted in a @percent@ reduction ( P < @number@ ) of cardiomyocyte diameter and 3-fold increase in interstitial myocardial fibrosis.
The 6-month program includes three in-home visits , monthly group sessions , monthly team meetings for providers , and nurse-led care coordination.
The 70- to 80-year-olds have an eightfold higher RBC consumption than 20- to 40-year-olds.
The 72-hour average insulin infusion rates were @number@ ± @number@ and @number@ ± @number@ U / hr ( p = not significant ) .
The 7KFAEs are not toxic and do not induce inflammatory responses.
The 7-valent conjugated vaccine is more immunogenic and efficient in children and first studies demonstrate its efficacy in immunosuppressed persons.
The 7-year-old boy had short stature and craniofacial malformations including macrocephaly , midface hypoplasia , micrognathia , frontal bossing , and down-slanting palpebral fissures.
The 8-feet walk time also significantly decreased ( @percent@ , P < @number@ ) .
The 8-halo-7-deaza-dGTP derivatives were poor substrates for but strong binders to hMTH1.
The 8-week intervention periods were separated by a 4-week wash-out.
The 8-week PEP was implemented with the intervention group.
The 90-day mortality rate was @percent@.
The 90-day mortality rate was @percent@ , and dialysis was required in @percent@ of patients ( 9 / 623 ) .
The 90-day mortality was @percent@ in patients with transient AKI and @percent@ in patients with persistent AKI.
The 95th percentile of ACR was used as the normal upper limit.
The 95th percentile values for GA and HbA1c in controls were @percent@ and @percent@ , respectively.
The 99th percentile URL of a healthy population was calculated to be 43ng / L with no significant difference between genders or sample types.
The A10398G mitochondrial SNP has been inversely associated with risk of PD in some studies.
The A1GP racing simulator ( Allinsport , Modena ) established a realistic race platform.
The A30 : P70 and A50 : P70 ratios were also not correlated with maximal walking speed.
The A30P mutation is known for its fast oligomerization , but slow fibrillization rate.
The AABFC harbors antibodies against ARMs.
The AA genotype groups also showed an apparently higher rate and earlier onset of incident fractures than the other genotypes.
The AA in patients < 50 years were the most distensible compared to other aortic regions.
The AAI was evaluated using a portable Doppler and mercury column manometer.
The A allele of the G395A polymorphism of klotho may be associated with the risk of mortality in Korean hemodialysis patients.
The AAL technologies are designed to meet the needs of the aging population in order to maintain their independence as long as possible.
The a ( ) and EI value increased in red-light-PDT group.
The abbreviated Barcelona Test ( a-BT ) is an instrument widely used in Spain and Latin American countries for general neuropsychological assessment.
The abdominal visceral fat area and thigh muscle cross-sectional area ( CSA ) were quantified by computed tomography.
The aberrant expression of miRNAs may contribute to phenotypic features of malignant cells , including resistance to chemotherapy.
The abilities of the technique are to perform spectral profiling and to identify single cells with different potentials to synthesize GAGs.
The ability for GWIR to discriminate between these groups was assessed on its own and as an adjustment factor for cortical thickness.
The ability of ARTSENS to detect age-related trends in arterial compliance was also investigated.
The ability of ASA to increase anti-inflammatory LXA₄ and 15-epi-LXA₄ and reduce pro-inflammatory PGE₂ and TXB₂ suggests considering aspirin further for treating clinical neuroinflammation.
The ability of cofilin to displace drebrin from actin filaments is pH dependent and is facilitated at acidic pH ( @number@ ) .
The ability of ( - ) -epigallocatechin gallate ( EGCG ) to retain its antioxidant effect even in the presence of H2O2 was investigated.
The ability of F2RL3 methylation to predict lung cancer was examined by Harrell's C statistics.
The ability of IGF-1R ( + ) hCSCs to regenerate infarcted myocardium was then compared with that of unselected c-kit ( + ) hCSCs.
The ability of injured axons to regenerate declines with age , yet the mechanisms that regulate axon regeneration in response to age are not known.
The ability of MGP to inhibit calcification requires the activity of a vitamin K-dependent enzyme , which mediates MGP carboxylation.
The ability of @number@ younger and older adults to visually perceive exocentric distances was evaluated.
The ability of organisms to adapt to their environment during aging is altered.
The ability of the ABC-H scale to predict future falls was adequate with high sensitivity and specificity values.
The ability of the human immune system to repel infections is drastically diminished with age.
The ability of these self-tests to accurately distinguish MCI and dementia from SCD was examined with ROC curves.
The ability of the system to detect artery anatomy and measure compliance was verified by in-vivo measurements conducted on @number@ subjects.
The ability to achieve peak propulsive force within a short time is critical for the performance of such a quick powerful step.
The ability to adapt vergence peak velocity and the rate of phoria adaptation showed no significant age-related influence ( p > 0.05 ) .
The ability to associate items in memory is critical for social interactions.
The ability to attend to multiple objects that move in the visual field is important for many aspects of daily functioning.
The ability to conceive was shown to be associated with age , tumor histology and type of conservative surgery.
The ability to control locomotion through the environment and to intercept , or avoid objects is fundamental to the survival of all locomotor species.
The ability to detect errors during cognitive performance is compromised in older age and in a range of clinical populations.
The ability to discriminate speech sounds is crucial for higher language functions in humans.
The ability to encode and retrieve spatial and temporal contextual details of episodic memories ( context memory ) begins to decline at midlife.
The ability to encode a simple signal was related to degradation in the neural representation of a complex , speechlike sound.
The ability to identify and study individuals about to die of natural causes with no apparent diseases is a game-changer in this field.
The ability to identify these women would be critically important if decreased ovarian reserve were associated with increased long-term health risks.
The ability to interact with 14-3-3 correlates with the pattern of intracellular LRRK2 distribution.
The ability to learn new movements and dynamics is important for maintaining independence with advancing age.
The ability to maintain a functional proteome , or proteostasis , declines during the ageing process.
The ability to maintain balance deteriorates with increasing age.
The ability to maintain stability in the frontal plane ( medialateral direction ) while walking is commonly included as a component of motor performance assessment.
The ability to manage these competing demands is compromised by the progressive sensory , neural and motor declines associated with aging.
The ability to measure human biological aging using molecular profiling has practical applications for diverse fields such as disease prevention and treatment , or forensics.
The ability to modulate sympathetic α-adrenergic vasoconstriction in contracting muscle is impaired with age.
The ability to perceive causality is a central human ability constructed from elemental spatial and temporal information present in the environment.
The ability to perform multiple tasks simultaneously has become increasingly important as technologies such as cell phones and portable music players have become more common.
The ability to quantify DNA damage responses is thus critical in the public health , pharmaceutical and clinical domains.
The ability to quantify these changes and assess response to therapies will be pivotal in understanding disease mechanisms and monitoring efficacy of therapy.
The ability to recognize speech in noise was measured twice with the online National Hearing Test , a digit-triplet speech-in-noise test.
The ability to regulate translocation by the p97-AIRAPL complex is entirely dependent on the proteins ' signal peptide.
The ability to remember associations between previously unrelated pieces of information is often impaired in older adults ( Naveh-Benjamin , @number@ ) .
The ability to remember the spatial context in which our experiences occur declines linearly across the adult lifespan.
The ability to retrieve temporal and spatial context information from memory declines with healthy aging.
The ability to safely perform cognitive-motor dual-tasks is critical for independence of older adults.
The ability to study regenerative and non-regenerative stages in Xenopus laevis makes it a unique model system to study regeneration.
The ability to suppress irrelevant information declines with age , while the ability to enhance relevant information remains largely intact.
The ability to understand speech under adverse listening conditions deteriorates with age.
The ability to use thoracic quantitative computed tomography ( QCT ) to detect the annual change of BMD remains unclear.
The ability to walk independently contributes to the mobility , but is increasingly restricted by numerous diseases that impair gait and balance.
The ABI was calculated for each leg , as the ratio between the lowest ankle pressure and the highest brachial pressure.
The ablation success rate for RVOT-VA ( @percent@ ) was higher than that for LVOT-VA ( @percent@ ; P < 0.0001 ) .
The abnormal elongation of the CAG increases the polyglutamine stretch of huntingtin , which becomes proportionally toxic.
The abnormalities in the remote ( not local ) default network connectivity were significantly associated with episodic memory performance in patients.
The Aboriginal population in Canada , much younger than the general population , has experienced a trend towards aging over the past decade.
The above expert tables can be used in urological departments practicing contact ureterolithotripsy for ureterolithiasis , and in medical high schools for teaching students.
The above findings suggest a novel mechanism for polyphenols ' neuroprotective effect in neurodegeneration and galangin as a potential drug candidate for AD therapy.
The above HPC subtypes were not proliferating.
The above is supported by evidence to eventual increase of the probability of heteroplasmy with age due to specific mitochondrial haplogroup background.
The above significant associations remained in the lag time analyses , applied to check for reverse causation.
The absence of a control group precludes definitive conclusions about the nature of these changes or if their degree is beyond normal aging.
The absence of a specific deficit of short term memory for conjunctions of surface features seems to distinguish cognitive ageing from Alzheimer's Disease.
The absence of changes in older fibromyalgia subjects is probably related to the ageing process of controls.
The absence of drugs indicated for frequently under-treated conditions before and after CGA was compared.
The absence of interset statistical differences allowed us to perform joint and conjunction analyses.
The absence of movement , the lack of function of any organ or system leads to the inefficiency , atrophy and death.
The absence of nuclear DNAPK holoenzyme correlates with premature as well as physiological ageing.
The absence of scars and surgical risk makes this technique useable for a large number of patients.
The absence of telomere attrition with age among patients with PD could reflect a telomere regulation by mechanisms other than age.
The absence of transfer effects may also point to its limits.
The absence of vascular risk factors and depressive symptoms did not modify the predictive role of reversible cognitive frailty on these outcomes.
The absolute amplitude values of the Mm. gastrocnemii showed no differences in the age groups while the relative levels were decreased.
The absolute and @percent@ FI limits were calculated for different age groups and analyzed by sex.
The absolute and relative between-country disparities decreased during the study period.
The absolute differences in death risks increased with parents ' age and were somewhat larger for men than for women.
The absolute ethnic differences in seroprevalence decreased in subsequent cohorts , but the relative ethnic differences increased.
The absolute mean rCBF values were consistent with the ones reported from PET , as was the relatively low variability in different feeding arteries.
The absolute risks of early retirement and becoming economically inactive were lowest in countries with a Scandinavian welfare state regime.
The absolute stereochemistry of @number@ was further confirmed by X-ray single crystallography analysis.
The absolute test-retest difference was close to zero for low as well high degrees of cataracts.
The absorption , distribution , metabolism and elimination of drugs are discussed in the context of breast cancer.
The absorption of UVL results in photochemical reactions involving reactive oxygen species ( ROS ) with consequent damages to the skin.
The abstract selection was based on the Strobe checklist for observational studies.
The abstracts of all articles were read , classified and examined to identify patterns over time.
The abstracts of these papers were read to determine their relevance to the purpose of this paper.
The ABS was administered to @number@ patients ; a total of @number@ ABS tests were completed for these patients.
The abundance of many of the key transport proteins that contribute to urine concentrating ability is reduced in the kidney medulla of aged rats.
The abundance of stem cells harvested from adipose tissue enables us to instantly apply primary cells without culture expansion.
The abutments in Group A failed early due to fractures of the internal parts and parts close to the implant neck.
The academic medicine community must play an expanded role in filling evidence gaps in order to continuously improve health policy making among U.S. states.
The ACA may modestly exacerbate the shortage.
The accelerated hydrothermal aging testing ( at @number@ °C , 2-bars pressure ) was conducted up to @number@ h.
The acceleration data on flexion / extension corresponded to this finding.
The acceleration of IVD degeneration observed in PGRN null mice was probably due to the enhanced activation of NF-κB signaling and β-catenin signaling.
The accelerations of the limbs were recorded during the clinical tests with an accelerometer network distributed on the body.
The acceptability of a high-calorie-expenditure ( HCE ) exercise program in older coronary heart disease patients participating in a behavioral weight-control program was evaluated.
The account predicts that stereotype threat decreases the availability of executive-control resources and hence should impair working memory performance.
The Accreditation Council for Graduate Medical Education approved the training requirements in @number@
The Accreditation Program for Healthcare Organizations should include Senior-Friendly Hospitals -relevant standards considering Korea's medical environment.
The accrual of large genotyped AN case-control samples should be an immediate priority for the field.
The accumulated scientific data presented here point to a serious need to lower the recommended amount of parenteral Cr.
The accumulating evidences indicate that DNA methylation patterns change with age.
The accumulation and aggregation of phosphorylated tau proteins in the brain are the hallmarks for the onset of Alzheimer's disease ( AD ) .
The accumulation of advanced glycation end products ( AGEs ) in skin plays a very important role in skin ageing.
The accumulation of AGEs is associated with various disease conditions that include complications in diabetes , Alzheimer's disease and aging.
The accumulation of altered proteins and damaged mitochondria , particularly at axon terminals , ultimately might overwhelm the capacity of intracellular disposal mechanisms.
The accumulation of amyloid-β ( Aβ ) peptide is one of the major neuropathological hallmarks of Alzheimer's disease ( AD ) .
The accumulation of amyloid-β ( Aβ ) plaques is a central feature of Alzheimer's disease ( AD ) .
The accumulation of Aβ is considered the first step of AD pathophysiology.
The accumulation of cerebral amyloid βpeptide ( Aβ ) is a key precipitating factor for neuronal cell death in Alzheimer's Disease ( AD ) .
The accumulation of crystallin fragments in vivo and their subsequent interaction with crystallins are responsible , in part , for protein aggregation in cataracts.
The accumulation of damage caused by these multiple parametabolic processes results in the reduction of vitality generally known as aging.
The accumulation of damaged proteins can perturb cellular homeostasis and provoke aging , pathological states , and even cell death.
The accumulation of damaged proteins contributes to multiple age-related diseases such as Alzheimer's , Parkinson's or Huntington's disease.
The accumulation of epigenetic changes was proposed to contribute to the age-related increase in the risk of most common diseases.
The accumulation of human capital also varies across the transition.
The accumulation of irreparable cellular damage restricts healthspan after acute stress or natural aging.
The accumulation of lipofuscin with age was documented with the diminution in the size of epithelial cells.
The accumulation of misfolded or damaged proteins is an important determinant of the aging process.
The accumulation of OS causes damage to lipids , proteins and DNA in the placental tissue that induces a form of accelerated ageing.
The accumulation of pre-clinical evidence should promote further epidemiological and controlled clinical studies.
The accumulation of progerin in HGPS cells leads to an aberrant nuclear morphology , genetic instability , and p53-dependent premature senescence.
The accumulation of progerin in HGPS nuclei causes numerous morphological and functional changes that lead to premature cellular senescence.
The accumulation of recent negative life events did not affect cognitive functioning over a longer time period.
The accumulation of senescent cells in tissues and organs with time plays a role in organismal aging and in several age-associated disorders and pathologies.
The accumulation of senescent stromal cells in aging tissue changes the local microenvironment from normal to a state similar to chronic inflammation.
The accumulation of several oxidation products in neurons during aging prompts the idea that consumption of antioxidant compounds may delay neurodegenerative processes.
The accumulation of such peptides in aging lenses may explain a novel mechanism for age-related crystallin aggregation and cataractogenesis.
The accumulation of unfolded protein in the endoplasmic reticulum induces an adoptive mechanism called the unfolded protein response ( UPR ) .
The accumulation of unhealthy mitochondria results in mitochondrial dysfunction , which has been implicated in aging , cancer , and a variety of degenerative diseases.
The accumulation of VRF increasingly affected WM integrity , particularly in areas known to be injured in patients with mild cognitive impairment and dementia.
The accuracy achieved by the classifiers in differentiating the age cohorts was used as a surrogate measure of the aging signal in the different tissues.
The accuracy can be further improved in studies including more risk factors and younger cohorts with long-term follow-up.
The accuracy deteriorated with advancing age in NHAP but not CAP.
The accuracy in predicting residual reproductive lifespan is still needed in both users and non-users of OC.
The accuracy in predicting treadmill results from the WIQ score was fair in group @number@ and nonsignificant in group @number@
The accuracy is affected by current BMI , changes in weight , end-digit preferences , and current cognitive ability.
The accuracy of BIA may be influenced by the expansion of extracellular water ( ECW ) relative to muscle mass with aging.
The accuracy of compliance estimates were evaluated by comparison with a state of art imaging system.
The accuracy of discriminating aMCI from NC was @percent@ by using left frontal match / nonmatch effect combined with nonmatch reaction time.
The accuracy of each algorithm to predict progression to dementia over @number@ years was examined for @number@ individuals.
The accuracy of MEWS in predicting the in-hospital mortality was assessed with the area under the receiver-operating characteristic curves.
The accuracy of predictive equations for calculating resting energy expenditure ( REE ) in elderly people has been questioned.
The accuracy of the fitting and reliability of the model suggest applications both at the diagnostic and therapeutic level.
The accuracy of three models was @percent@ , @percent@ , and @percent@ , respectively.
The accuracy rate for the age estimation by this method was @percent@.
The accuracy with which significant others can predict how an older adult envisions HRQoL in a future state of cognitive impairment is also unknown.
The accuracy with which young and older participants reproduced remembered reference hand positions was assessed under different experimental conditions.
The accurate age estimation of adults is an important step in the construction of the biological profile of skeletonized remains.
The accurate and precise estimation of liver volume is therefore essential.
The ACE I / D genotype met Hardy-Weinberg expectations in all the cohorts.
The ACE-R was able to successfully discriminate between patients and healthy subjects.
The ACES framework identifies three unique concepts integral to delivering high quality care.
The acetabular rim is a highly specialized structure known as the labro-acetabular complex.
The acetylation of Histone H3 ( K9 ) and H4 ( K16 ) of the IL-8 and IL-6 promoter regions gradually increased during cellular senescence.
The AC group undertook a \ "media workshop \ " of six sessions focused on learning journalistic techniques.
The AC haplotype shows a significantly higher methylation level than the GT haplotype.
The ACP demonstrated greater vigilance than usual care in ensuring completeness and accuracy in charted medication orders.
The acquired quantitative proteomic dataset was subjected to the development of biomarker signatures predicting prognostic clinical endpoints.
The acquisition of cognitive reserve has been linked to the performance of certain intellectual and cognitive activities throughout the whole of the individual's life.
The acrophase of LF / HF was earlier in females than in males , and in younger individuals than in older individuals.
The ACR value for girls was significantly higher than that for boys ( P < 0.001 ) .
The AC stimuli had higher thresholds for oVEMPs than for cVEMPs and all three stimuli produced higher asymmetry for the oVEMP than for the cVEMP.
The Actigraph activity-monitoring accelerometer underestimated gmax by an average of @percent@ ; underestimation by the X6-2mini was not significant.
The actin cytoskeleton plays a dual function as sensor and target of oxidation , in tight connection with the former signalling cascades.
The action mechanisms of @number@ in human neutrophils were further investigated.
The action of compound @number@ as a PPARβ / δ agonist was determined by reporter gene assay , immunostaining , and Western blotting.
The action of Klotho is enzymatic in nature which includes alteration of transport activity and the more traditional means of regulation by trafficking.
The action of n-3 PUFA on the aging brain might therefore differ according to ApoE polymorphism.
The actions of melatonin on radical metabolizing / producing enzymes may be mediated by the Keap1-Nrf2-ARE pathway.
The actions of the learning community's leadership , state governments , and local programs together may have contributed to the high sustainment rate.
The activated HPA axis is a risk for depression.
The activation and cytoplasmic localization of p38 in H ( @number@ ) O ( @number@ ) -treated KGN cells were blocked by N-acetylcysteine and SB203580.
The activation capacity of AMPK declines in metabolic stress and with aging which could augment the metabolic diseases and accelerate the aging process.
The activation of adiponectin / AdipoR has caloric restrictive and exercise-mimicking effects thus prolonging lifespan.
The activation of caspase-2 can be measured by assessing its dimerization and / or cleavage of the caspase-2 zymogen and its substrates.
The activation of H69 cells by lipopolysaccharide ( LPS ) resulted in the induction of RelB and p100 expression.
The activation of hepatic stellate cells ( HSCs ) is a key event in the process of liver fibrosis.
The activation of p38 and JNK mitogen-activated protein kinases ( MAPK ) after UVB irradiation was also inhibited by phlorizin.
The activation of stimulus-responsive transcription factors may explain many of the intracellular activities of resveratrol.
The activation phenotype was independently associated with the anti-cytomegalovirus IgG levels and with functional and cognitive decline.
The activation state of NK cells , reflected by telomerase activity and intracellular interferon γ ( IFNγ ) content , was also measured.
The active acquisition of epigenetic changes is a poorly understood but very important process in mammalian development , differentiation , and disease.
The Active Australia survey was used to assess walking , moderate , and vigorous physical activity.
The active form stimulates the Keap1 / Nrf2 transcriptional pathway and thus production of phase @number@ antioxidant enzymes.
The active phase consists of bi-monthly in-person coaching with access to a full suite of eHealth technology supports.
The active secretion of tau could be a physiological response of neurons to increased intracellular amounts of tau during the progression of tau pathology.
The activities created by Maria Montessori seem to be adaptable to this clientele.
The activities of BCX were significantly attenuated by activators of α7-nAChR / PI3K signaling or by overexpression of constitutively active PI3K.
The activity and aggregation of RBPs appears to be important in the context of unfolded protein diseases.
The activity and mass of the muscles in the body make them susceptible to constant injury.
The activity and protein level of TH are decreased to cause DA deficiency in the striatum in PD.
The activity and regulation of the axis has been related to cognitive decline during aging.
The activity and the expression of matrix metalloproteinases ( MMP ) - @date@ was evaluated by zymography and Western blot analysis , respectively.
The activity facilitated the use of optimal movement strategies in young and older adults.
The activity level of each child was characterised , with @percent@ reliability , by averaging their eight annual physical activity measures.
The activity of Aurora B is reduced and the localization of Aurora B on the central spindle is disturbed in anaphase cells without p21.
The activity of carotid chemoreceptor is modulated and significantly contributes to the ventilatory acclimatization at high altitude.
The activity of CHIP is regulated by two co-chaperones , BAG2 and HSPBP1 , which are potent inhibitors of the E3 ubiquitin ligase activity.
The activity of EZH2 influences cell fate regulation , namely the balance between self-renewal and differentiation.
The activity of glycolytic , antioxidant , and Na + / K ( + ) -ATPase enzymes decreased with erythrocyte aging in vivo.
The activity of KRAS is regulated by guanine nucleotide exchange factors ( GEFs ) , GTPase-activating proteins ( GAPs ) , and also post-translational modification.
The activity of SA-β-galactosidase was significantly increased , but the proliferation capacity was significantly reduced as compared to young control.
The activity of SOD1 and CAT was upregulated , and LF accumulation was inhibited by CSOL.
The activity of the antioxidant enzyme paraoxonase-1 toward two substrates was determined by spectrophotometry.
The activity of the isoxazole analogues depends on the nature and the number of the antioxidant substituents.
The activity of the thyroid gland diminishes during ageing , but a certain tissue reserve of T3 and its metabolites is maintained.
The activity of this compound and of a series of chemical analogues was investigated in selected tumor cell lines , expressing both PPARα and PPARγ.
The activity participation model explained more variance in physical functioning among older women than in the whole sample , including both males and females.
The activity significantly increased time taken to rise from floor-sitting ( p = @number@ ) .
The activity stimulating PrP conversion was specific for plasminogen and conserved in its kringle domains.
The ACTN3 R577X genotype accounted for @percent@ of the variability in the results of the chair stand test among men in the ≥55 age group.
The actual daily total calorie and nutrient intake was also calculated.
The actual data indicate opposite effects of nicotine in the CNS.
The actual meaning and material content of this human right is subject to debate.
The actual molecular mechanism behind the progression of dysfunctional autophagy is not yet fully understood.
The acupuncture-moxibustion serum has received wide attention as a new idea and method.
The acute care surgery model has been developed in which the trauma team also manages all general surgical emergencies to improve patient outcomes.
The AC was measured in centimetres at the H of the navel and body composition was ascertained using bioimpedance analysis.
The AD8 detected MCI in all @number@ individuals , whereas the IQCODE misclassified @number@ individuals.
The AD8 , however , was more successful than IQCODE in detecting MCI.
The ADAP short version is considerably shorter than the original test and provides a good representation of the constructs being measured.
The adaptation , the \ "Mistreatment of Older Adult Risk Factors \ " tool , offers a comprehensive tool for screening in the home setting.
The adaptive algorithm allowed reaching an average assessment duration < 15 minutes , making its clinical applicability realistic.
The adaptive immune response is regulated primarily by mechanisms that affect the balance between regulatory and effector T cells.
The adaptive immune response should be abolished to avoid graft rejection by the host.
The adaptive immune system requires a diverse T-cell repertoire to be able to respond to a wide variety of pathogens.
The adaptive nature of regulated variation can be explained by the differential success of lineages in macro-evolution.
The adaptive shift to the ketogenic system as an alternative fuel coincided with decline in mitochondrial function.
The AD brain shows increased levels of lipid peroxidation products , including 4-hydroxy-2-nonenal ( HNE ) .
The AD-CSF-indices have a high sensitivity and specificity of @percent@ to @percent@ and @percent@ , respectively , in differentiating patients with AD from nondemented controls.
The ADCs were estimated using both fat-saturated and non-fat-saturated diffusion-weighted imaging via a periodically rotated overlapping parallel lines with enhanced reconstruction ( PROPELLER ) technique.
The ADC values of @number@ kidneys with VUR were compared with those of @number@ kidneys without VUR.
The ADC values of right amygdala and left cingulum interestingly showed negative relation and the left hippocampus represented positive relation with age.
The added effect of having a premutation decreased AMH levels by @percent@.
The addicted population was more severe as a function of age on all indices ( p < 0.05 ) .
The additional antithrombotic properties displayed by ticagrelor may explain its greater efficacy in reducing thrombotic events in clinical trials.
The additional cognitive load made the age differences in the Stroop task reappear even when visual perceptual stress was equivalent.
The additional health burden placed on those who are already disadvantaged is likely to become an increasingly important issue in an ageing population.
The ( additional ) prevalence of severe ( 70-99% ) stenosis is @percent@.
The addition of a cognitive task did not further worsen balance performance in KTRs.
The addition of actoxumab did not improve efficacy.
The addition of blunt cannulas to the clinical setting may be appropriate.
The addition of calcium depends on tolerance , history of kidney stones , and emerging data regarding its cardiovascular safety.
The addition of CTR to HP medium was able to recover Klotho expression.
The addition of frailty improves the ability of the EuroSCORE II to predict postoperative delirium , pointing to opportunities for improved prevention and management.
The addition of hip shape to fracture-prediction tools may improve the risk assessment for osteoporotic hip fractures.
The addition of new etiological categories such as fronto-temporal NCD or NCD with Lewy bodies should also to be considered as a significant improvement.
The addition of NT-proBNP to the SHFS ( @number@ versus @number@ P = 0.168 ) generated marginal growth in the c-statistic.
The addition of @number@ mg of TRIAL REGISTRATION : This trial ( NCT02952014 ) was retrospectively registered on @date@ .
The addition of nutritional supplementation resulted in further declines in intermuscular fat and improved muscle density compared to placebo.
The addition of other variables to HARP did not improve its diagnostic accuracy for either measure of quality of life.
The addition of spironolactone to her previous medications controlled and normalized hypertension , hypokalemia , and hormonal abnormalities within @number@ months.
The addition of the gene score to a phenotypic risk model leads to a potentially clinically important improvement in discrimination of incident T2D.
The addition of vitamin E to the bulk material is a potential way to reduce the aging processes.
The adequate and controlled interaction between these components is necessary for a robust and strong immune response.
The AD group demonstrated a significant impairment in dual-task ability.
The AD group exhibited significantly lower total scores on both tests compared with the age-matched controls.
The adherence rate varied from @percent@ to @percent@.
The adipokine's association with new-onset HF remains less well defined.
The adipose area of the renal sinus did not correlate with any anthropometric measure.
The adipose area of the renal sinus did not correlate with any anthropometric measures.
The adipose tissue is metabolically active and an endocrine organ , whose dysregulation causes a low-grade inflammatory state and ectopic fat depositions.
The adjusted ethnic odds ( MA vs EA ) of incident frailty were estimated using generalized estimating equations.
The adjusted model included variables selected by backward elimination with a cut off of < @number@
The adjusted odds ratio for a 1-unit increase in HHIE score was @number@ ( @percent@ confidence interval : @number@ @date@ ) .
The adjusted odds ratio for prevalent diabetes in the lowest quintile of wealth compared with the highest was @number@ for men and @number@ for women.
The adjusted prevalence of a CAC score of @number@ HU or higher was @percent@ in the low-stable group.
The adjusted prevalence of pain @number@ months before death was @percent@ ( @percent@ CI , @percent@ to @percent@ ) .
The adjusted RORs for ETN ≥ @number@ and ADA ≥ @number@ groups were the lowest among the age-stratified groups undergoing the respective monotherapies.
The adjustment for vitamin C intake , but not dietary acid load , attenuated the association between fruit intake and bone mass.
The adjustment to the NLV device plays a crucial role.
The ADL scores for the two groups were compared.
The administration of CGA is time consuming and consequently some screening tools were developed.
The administration of cognitive tests among older adults may provide relevant information for patient care and treatment decisions.
The administration of more immunogenic vaccines can be beneficial in the elderly.
The administration of perioperative chemotherapy had no significant effect in improving the survival , as assessed by the Kaplan-Meier method.
The administration of prehospital analgesia was associated with significant pain relief.
The administration of sulodexide could potentially be used in prevention of atherosclerotic changes.
The admission rates significantly fell for both men and women and for all examined age categories after both first and second phases of the ban.
The adolescent period is associated with high significance of interactions with peers , high frequency of stressful situations , and high rates of alcohol use.
The adolescents with low PA were mostly football and basketball players.
The adoption of assistive technology devices for physical intervention tends to motivate and retain older people exercising for longer periods of time.
The adoption of user profile and persona has not received much attention in health care informatics research and , in particular , research involving CHT.
The AD-related differences were also leftward.
The adrenal response to cortrosyn was assessed by the hormonal rise observed at @number@ minutes , and by the area under the response curve.
The ADs alone may be insufficient to prepare diverse patients and surrogates for complex medical decisions.
The Adults and Older Adults Functional Assessment Inventory is a new measure of basic and instrumental activities of daily living.
The adult with congenital heart disease ( CHD ) is at risk of developing atherosclerotic cardiovascular disease ( ASCVD ) .
The AD / VaD ratio increased from @number@ in the early 1990s to @number@ in the 2010s , similar to the worldwide ratio.
The advanced-age , frail elderly are especially vulnerable to developing pneumococcal infection and disease.
The advanced glycation endproducts ( AGEs ) are elevated in AD brains and the AGEs can stimulate β-amyloid production.
The advanced glycation end-products ( AGEs ) are the consequence of non-enzymatic reactions between lipid and protein with several oxidants in the aging process.
The advanced maternal age had no significant effects on the risk for schizophrenia in offspring.
The advance in its understanding will help to the development of potential therapeutic agents to alleviate and treat sarcopenia and other related myophaties.
The advances in healthcare over the past several decades have resulted in populations now living longer.
The advantage of AMH in relation to the ovarian steroid hormones is that serum levels do not fluctuate significantly during the menstrual cycle.
The advantage of PMMA microsphere is that the result seems to be predictable and natural.
The advantage of the ex vivo operation made it possible to perform safe and definitive cancer resection without massive bleeding.
The advantage of the pneumococcal conjugate vaccine is the additional induction of a T-cell dependent immune response that leads to good immunogenicity despite immunosenescence.
The advantages and disadvantages of each approach are discussed and techniques briefly described.
The advantages and limitations of the behavioral models in assessing memory and the link to the long-term potentiation are discussed.
The advantages as well as the limits of proteomics in view of the identification of new biomarkers are evaluated.
The advantages of HSOA include its statewide reach and integration with county aging services.
The advantages of MR imaging in bone dysplasias caused by TRPV4 mutations are emphasized in this article.
The advantages of quantitative over qualitative diagnostic approaches have been widely acknowledged and demonstrated.
The advantages of this system is an electron transport train which is able to adapt to changes in its environment.
The advent of molecular genetic testing panels in hematology clinical practice has complicated the evaluation of older patients with unexplained anemia.
The advent of next-generation sequencing has dramatically decreased the cost for whole-genome sequencing and increased the viability for its application in research and clinical care.
The advent of transcranial magnetic stimulation ( TMS ) combined with electroencephalography ( EEG ) has allowed for the assessment of functional neurotransmission in vivo.
The adverse effect of free radicals can be neutralized by antioxidants.
The adverse effects of complexity of dual tasks on postural stability were also revealed among patients with multiple sclerosis ( @number@ to @number@ ) .
The adverse effects of some orthodontic materials should be considered during material selection and throughout orthodontic treatment , in order to minimise possible undesirable implications.
The adverse event profiles were similar between the titration and double-blind maintenance phases.
The adverse events in five patients in the low-dose cohort and in eight patients in the high-dose cohort were considered to be drug related.
The adverse reactions to HEMA / EMA in HA were severe in @percent@ of the patients.
The aerobic exercise group included @number@ individuals and the control group included @number@ individuals who reported low aerobic exercise at baseline.
The aerobic glycolytic phenotype of hepatocellular carcinoma ( HCC ) is often correlated with tumor progression and poorer clinical outcomes.
The aerobic power , measured by VO₂max and @number@ meters performance , and the neuromuscular fitness and quality of life were evaluated.
The aerobic training group significantly improved in maximal oxygen uptake and episodic memory performance.
The aesthetic experience , in particular the experience of beauty in the visual arts , should have neural correlates in the human brain.
The aesthetic outcome , patient satisfaction , and development of eyelid malposition were evaluated.
The AEs were minimal and no significant complications occurred.
The aetiology of idiopathic PD largely remains an enigma.
The aetiology of several cardiovascular disorders is thought to involve impaired mitochondrial function and oxidative stress.
The aetiology of the effusions was determined using standardised criteria.
The aetiology of these results and possible clinical and biological implications are discussed.
The aetiology of this condition is not well understood.
The AFC corresponding to the 5th , 25th , 50th , 75th , and 95th centiles for each age have been calculated.
The affected mRNAs resulted in either predicted targets for nonsense mRNA decay ( NMD ) or non-functional isoforms.
The affinity of radiolabeled cCPE.GST for claudin-4 was confirmed using claudin-4-expressing MDA-MB-468 and SQ20b cells , compared with claudin-4-negative HT1080 cells.
The Affordable Care Act will place greater emphasis on preventing complications and reducing hospital-acquired infections.
The AF group showed elevated levels of serum triglyceride ( TG ) and C-reactive protein with hyperuricemia.
The AF lamellar architecture is established early in development.
The AFM images of most of the older subjects revealed dilapidated structures , poorly demarcated scale edges and undulated surfaces.
The aforementioned aging functions were used to develop FE models representing two additional ages : @number@ and @number@ YO.
The aforementioned are all related to the determinants of active aging.
The aforementioned velocity values obtained in the right lobe may be used as reference values for normal liver stiffness in children.
The African Americans had a significantly higher percentage of occurrence of meridional fibers than did the Caucasians ( P < @number@ ) .
The age-adjusted AMI hospitalization rate for men showed a decline of @number@.87 / 100 , 000 population ( P = @number@ ) .
The age-adjusted annual incidence of clinically relevant GO is @number@ per @number@ population in women and @number@ in men.
The age-adjusted OR in men was @number@ ( @number@ @date@ ) .
The age-adjusted RF of ADC in 2007-2012 increased consistently in all the investigated areas.
The age-adjusted tissue Doppler Z-scores might avoid these disadvantages and be more discriminant for myocardial impairment than the raw velocities.
The age and development of axial length were statistically significant factors influencing the decline in sensitivity ( p = @number@ ) .
The age and education influences on the performance of the test and normative data are provided.
The age and the amount of myopia at stabilization were correlated ( r = @number@ P < @number@ ) .
The age-associated cumulative incidence of LRRK2 parkinsonism was also estimated using case-control and family-based designs.
The age-associated decline of adult stem cell function contributes to the physiological failure of homeostasis during aging.
The age-associated increase in recovery time results in the accumulation of deficits.
The age at death ranged from @number@ to @number@ years , with an average of @number@ years.
The age at onset of first symptoms was compared between monolingual and bilingual groups.
The age at which patients were diagnosed with PCNSL increased during the period of the study.
The age at which @percent@ of the general population died was @number@ vs. @number@ years in Tour de France participants.
The age-BMD correlation was negative for femoral neck while it was positive for the spine.
The aged artery is characterized by endothelial dysfunction and vascular smooth muscle cells altered physiology together with low-grade chronic inflammation.
The age data was stratified into 10-year intervals ranging from age @number@ to older than @number@
The age dependency of cell cycle regulation in human β-cells might explain the reduced β-cell regeneration in adult humans.
The age-dependent increase in VGF-expression could serve as mechanism that counterregulates the decrease in functionality of T lymphocytes.
The age-dependent liver repopulation by transplanted wild-type hepatocytes was investigated in juvenile and senescent rats deficient in dipeptidyl-peptidase IV.
The age-dependent nutritional status and resting metabolism in overweight and obese children have been examined.
The age-dependent pattern of adiponectin decrease in skin , correlated well with that of HA in skin.
The age-dependent racemization in total tissue samples proves that permanent or at least long-living proteins are present in scleral tissue.
The age-dependent random patterns are analyzed by a new functional principal component analysis that incorporates both covariate dependence and multilevel structure.
The age-dependent rise in SAF was steeper in smokers and in subjects presenting arterial hypertension.
The age-dependent shift towards Smad1 / @date@ signalling might trigger the differentiation of articular chondrocytes with an autolytic phenotype.
The age did not differentiate significantly the level of neuroticism and of extraversion.
The age differences in the inflammatory markers partly depended on the shift system.
The age differences in the reading-with-distraction task persisted when visual acuity was equated between older and younger adults ( Experiment @number@ ) .
The age distribution had two peaks , in the third and eighth decades.
The age distributions were noticeably different between thyroid cancer cases with and without tracheal invasion.
The aged model was developed by altering the geometry and material properties of the model developed for the 50-year-old.
The aged Tg mice also showed impaired glucose tolerance.
The age effect for egocentric pointing contrasts with previous findings showing preserved egocentric spatial abilities.
The age effect showed an increasing trend.
The age effect was incorporated to determine a model for straylight improvement.
The age effect was significantly stronger in females , the longer-lived sex.
The Age-Friendly Manitoba Initiative was launched in @number@
The age groups did not differ in measures of psychological distress or well being with the exception of older adults describing more autonomy.
The ageing context is highlighted in the concluding section.
The ageing effect is more pronounced in men.
The ageing human population is one of the most urgent challenges facing us today.
The ageing of biological tissues can be accelerated by many factors , mainly of physiological and nutritional nature.
The Ageing of societies is a unique historical development of mankind.
The ageing of the general population and thus of working population , too , is one of the crucial aspects of modern society.
The ageing of the population brings particular challenges to psychiatric practice.
The ageing population is currently one of the main issues facing UK healthcare systems.
The ageing process is characterized by deterioration of physiological function accompanied by frailty and ageing-associated diseases.
The ageing process is separate from , and independent of , exercise-mediated processes that maintain or adapt physiological function.
The ageing process is strongly influenced by nutrient balance , such that modest calorie restriction ( CR ) extends lifespan in mammals.
The age is significantly affecting the PEFR unlike BMI.
The age of an individual is an important , independent risk factor for many of the most common diseases afflicting modern societies.
The age of another @number@ dogs was predicted using data from the diseased dogs and the healthy poodles.
The age of bioinformatics offers hope , but only if creative systems approaches are forthcoming.
The age of human subjects was estimated through the analysis of human CCO activity from @number@ actual forensic cases.
The age of menopause onset in respect to CGG repeats was further analyzed.
The age of @number@ to @number@ years is an important transitional period.
The age of onset of presbyopia in familial amyloidosis patients was significantly lower than in control individuals ( @number@ years vs. @number@ years ) .
The age of onset was delayed by @number@ years when the patients were also carriers of the APOE genotype ε3 / ε3.
The age of patients was in the range from @number@ to @number@ ( mean , @number@ yr ) .
The age of patients was @number@ ± @number@ years.
The age of peak incidence was earliest in patients with occipital foci , followed by those with central foci and then those with frontal foci.
The age of the best marathon performance has been well investigated for flat city marathon running , but not for mountain marathon running.
The age of the children ranged from @number@ to @number@ year.
The age of the men under investigation was recorded , and their body mass index ( BMI ) was calculated.
The age of the participants at the beginning of this study ranged from @number@ to @number@ years.
The age of the participants significantly affected the LTP-like effect induced by QPS5 , which suggests that brain plasticity decreases with age.
The age of the participants was in the range @number@ - @number@ years.
The age of the patients ranged from @number@ to @number@ years ( mean age , @number@ y ) .
The age of the patients varied from @number@ to @number@ years , with an average age of @number@ years.
The age of the victim plays a crucial role for the legal implications concerning pornography.
The age , period , and cohort effects on mortality in China were generally comparable between urban and rural populations.
The age-period-cohort analysis showed a strong age effect , with women at the extremes of maternal age having the greatest risk of pre-eclampsia.
The age ranged between @number@ and @number@ years ( @number@ + @number@ years ) , with @percent@ male.
The age range of @number@ years and above was associated with a greater chance of non-participation in activities.
The age range of the monkey and baboon samples was not sufficient to justify an analysis of age dependence.
The age ranges produced from each approach were tested on an historic Italian sample , using cumulative binomial tests.
The age range was from @number@ to @number@ with a majority ( @percent@ ) female.
The age-related accumulation of maternal non-crossover gene conversions also mostly occurs within these regions.
The age-related altered expression of neuron-related proteins as seen in other regions of the central nervous system is expected in the aging retina.
The age-related annual rate of bone density loss was computed and compared to the thoracic and lumbar QCT , as well DXA measures.
The age-related capacity decline of DNA damage repair in human peripheral blood has been demonstrated.
The age-related central resistance to leptin and insulin does not reduce their inhibitory effects on the activity of NPY and AgRP neurons.
The age-related changes for controlling grip force in adults who practice regular and supervised physical activity have not been investigated.
The age-related changes in AMH were best fitted by a polynomial function.
The age-related comorbidities that HIV infected patients experience suggest that they suffer from accelerated aging.
The age-related decline in muscle function contributes to the movement limitations in daily life in old age.
The age-related decline in SCI for total serum testosterone concentration was @number@.6% / year compared to @number@.4% / year in the Massachusetts Male Aging Study.
The age-related decline in the encoding function may be due in part to changes in frontal lobe function.
The age-related decline was also observed in the tactile sensitivities of all fingers and in the pegboard test.
The age-related decrease in GH secretion ( \ "somatopause \ " ) may contribute to osteoporosis and atherosclerosis , commonly observed in the elderly.
The age-related decrease in parenchymal CBF was augmented in arterial spin-labeling compared with phase-contrast MR imaging.
The age-related decreases of FT and AR impair the physiological functions of androgen so as to accelerate the progression of coronary atherosclerosis.
The age-related differences in LV strain and torsion may reflect myocardial maturation and aging.
The age-related discrimination deficits were independent of sequence locations of both the target interval and the accented tonal component.
The age-related epithelial cancers of the breast , colorectum and prostate are the most prevalent and are increasing in our aging populations.
The age-related impact on gait performances appears reduced in this cohort.
The age-related impairment is an increasing problem due to the aging suffered by the population , especially in developed countries.
The age-related increase in activity was associated with changes in gaze behavior and improvements in social functioning.
The age-related influences are then reduced by robust subject-specific scaling.
The age-related loss in muscle force is attributable to loss of myofibers , myofiber atrophy , and a reduction in specific force.
The age-related loss of power is a fact , but the characterization or the rate of muscle power loss remains an open issue.
The age-related loss of skeletal muscle mass results from a chronic disruption in the balance between muscle protein synthesis and degradation.
The age-related miRNAs have synergism , which tend to work together as small modules.
The age-related reduction in membrane-associated Rho proteins was associated with a reduction in GGTase-Iβ levels that regulates binding of GGPP to Rho-GTPases.
The age-related reduction in the production of ovarian and adrenal androgens may significantly affect women's health.
The age-related WM deficit was not greatly affected , however , and the training gains did not transfer to the other cognitive tasks.
The age remains the main prognostic factor of glioblastoma.
The age , sex , occupation and number of children of the participants did not affect the ability to estimate age from facial images.
The ages of RA onset and AA amyloidosis diagnosis were estimated in each patient.
The ages of the older adults ranged from @number@ to @number@ years , while those of the younger adults ranged from @number@ to @number@ years.
The age-specific mortality rate for CVD increased with age in all three periods , especially for citizens older than @number@ years.
The age-specific prevalence of dementia approximately doubled with each @number@.8-yr increase of age.
The age-specific risk of prostate cancer among G84E mutation carriers was higher than among non-carriers.
The ages ranged from @number@ to @number@ years.We were unable to obtain sufficient information to reliably determine how both these studies were designed and conducted.
The age-standardized annual incidence of dementia is also high : @number@ per @number@ population , with @number@ new cases annually.
The age-standardized cancer incidence and mortality rates were @number@.63 / 100 @number@ and @number@.98 / 100 @number@ respectively.
The age-standardized grip strength among the female participants was @number@ kg and @number@ kg lower in Russia than in Denmark and in England , respectively.
The age-standardized incidence increased from @number@.6 / 100.000 person-years in @number@ to @number@.1 / 100 , 000 person-years in @number@
The age-standardized incidence rate for Canada was @number@ cases per @number@ person-years.
The age structure of early humans was balanced by fertility and mortality , with an exceptionally prolonged juvenility.
The aggregation of amyloid-β ( Aβ ) peptides plays a crucial role in the onset and progression of Alzheimer's disease.
The aging brain shows a progressive loss of neuropil , which is accompanied by subtle changes in neuronal plasticity , sensory learning and memory.
The aging brain undergoes several anatomical changes that can be measured with Magnetic Resonance Imaging ( MRI ) .
The aging characteristics of the RPE involve lysosomal accumulation of lipofuscin and extracellular protein aggregates called \ "drusen \ ".
The aging condition was determined by histochemical staining of senescence-associated β-galactosidase ( SA-β-gal ) .
The aging decreased the fluorescence intensity compared with initial values.
The aging effects on the concentration of these elements were also investigated.
The aging eye appears to be at considerable risk from oxidative stress.
The aging eye appears to be at considerable risk from oxidative stress.
The aging face in skin of color patients has a unique pattern that can be successfully augmented by dermal fillers.
The aging field is replete with theories.
The aging HIV population presents a new clinical concern for HIV providers : adverse effects from polypharmacy.
The aging immune system is unable to optimally respond to pathogens and generate long-term immunological memory against encountered antigens.
The aging immune system loses the ability to protect against infections and cancer and fails to support appropriate wound healing.
The aging-in-place movement presents numerous opportunities for consultant pharmacists.
The aging is one of the most important risk factors of upper GI injuries induced by LDA , such as gastric ulcer.
The aging model was established by subcutaneous injection of D-galactose for @number@ days.
The aging musculoskeletal system experiences a general decline in structure and function , characterized by a reduced adaptability to environmental stress.
The aging network has significant potential to enhance access to service utilization ; strategies for integrating behavioral health services in the aging network are discussed.
The aging of bone marrow cells and in particular , of adaptive immune cells in the bone marrow has been addressed relatively rarely.
The aging of current village doctors exacerbates the problem.
The aging of humans is a physiological and dynamic process ongoing with time.
The aging of our population implies management of increasing numbers of older patients who often have concomitant pathologies and , consequently , polypharmacy.
The aging of our societies is another reason.
The aging of skeletal muscle is characterized by a progressive decline in muscle mass , force , and condition.
The aging of swallowing , so-called presbyphagia , is still not noticeable by @number@
The aging of T cell memory is often considered in terms of senescence , a process viewed as decay and loss of memory T cells.
The aging of the human body is associated with the decline of cellular function which leads to the development of a variety of diseases.
The aging of the population and new developments in medicine both lead to the increasing number of elderly patietnts undergoing extensive surgery.
The aging of the population has been associated with an increased incidence and prevalence of neoplastic diseases.
The aging of the population has led to an increase in geriatric trauma.
The aging of the population increases the potential for serious consequences from a lapse in safety.
The aging of the population in the Western World results in a significant increase in the number of elderly patients with hematological malignant diseases.
The aging of the population in westernized countries constitutes an important issue for the health systems struggling with limited resources and increasing costs.
The aging of the population is one of the most important demographic events of the 21st century.
The aging of the population leads to increasing incidence rates of dementia.
The aging of the population raises new questions in the management of the colorectal surgery in the elderly.
The aging of the population worldwide has sharply increased the number of post-menopausal osteoporosis patients.
The aging of the U.S. population continues to highlight emerging issues in providing care generally for older adults and specifically for older adults with cancer.
The aging patient population has unique needs arising from progressive deterioration in both physiological and psychological abilities.
The Aging Perceptions Questionnaire was translated into Chinese version professionally.
The aging phase was initiated by flooding agricultural soils with rainwater in @number@ m ( @number@ ) fiberglass microcosm tanks.
The aging population has resulted in an increasing need for long-term enteral nutrition of patients with a wide range of disabling conditions.
The aging population , high chronic diseases prevalence and polypharmacy are closely associated factors.
The aging population increases the demand of intensive care unit ( ICU ) treatments.
The aging population is an undeniable reality which must be faced by all health systems all over the world.
The aging population is increasing dramatically.
The aging population will increase the demand for care of women with SUI.
The aging population with intellectual and developmental disabilities ( I / DD ) deserves appropriate health care and social support.
The aging process affects the structural organization and function of penile erectile components such as smooth muscle cell and vascular architecture.
The aging process and menopausal transition are important factors in sexual dysfunction of menopausal women.
The aging process and menopause are two potent contributors to female sexual dysfunction.
The aging process causes a number of changes in the skin , including oxidative stress and dyschromia.
The aging process conveys multiple changes in the organism , as well as changes in individual's surroundings.
The aging process has also been shown to affect the facial bones.
The aging process in vascular smooth muscle is characterized by : ( @number@ ) Altered replicating potential.
The aging process involves an inherent decrease in physiological abilities.
The aging process is a normal stage in development characterized by the gradual deterioration of all life functions.
The aging process is associated with a decline in mitochondrial functions.
The aging process is associated with decreasing muscle strength and an increasing risk of falling.
The aging process is a universal , intrinsic , progressive accumulation of deleterious changes in cells and tissues that increases morbidity and leads to death.
The aging process is characterized by a gradual derotation and deprojection of the nasal tip.
The aging process is characterized by a high level of complexity , which makes the care of older adults particularly challenging.
The aging process is characterized by gradual changes to an organism's macromolecules , which negatively impacts biological processes.
The aging process is driven at the cellular level by random molecular damage that slowly accumulates with age.
The \ "aging \ " process is essential for better understanding the toxicity and fate of NPs in the environment.
The aging process is frequently characterized by an involuntary loss of muscle ( sarcopenia ) and bone ( osteoporosis ) mass.
The aging process is unavoidable and often augmented by extrinsic forces , such as ultraviolet radiation.
The aging process leads to normative age-related bodily and functional declines and numerous social changes and life events that potentially threaten the self-concept.
The aging process leads to significant alterations in many organ systems , with the kidney being particularly susceptible to age-related changes.
The aging process results in remarkable changes in the kidney.
The aging process seems to be associated with oxidative stress and hence increased production of lipid peroxidation products , including isolevuglandins ( isoLGs ) .
The aging rate in Japan is the highest in the world , and it is entering a very aging society that has never happened before.
The aging rates are the same for males and females.
The aging-related genes were categorized by a set of structural terms from Gene Ontology ( GO ) .
The aging risk factor for Parkinson's disease is described in terms of specific disease markers including mitochondrial and gene dysfunctions relevant to energy metabolism.
The Aging Semantic Differential ( ASD ) is the most widely used instrument to measure young people's attitudes towards older adults.
The aging slope of the isopter areas were significantly larger in I / 4 than in V / 4.
The aging society has arrived , and home care options are being promoted.
The aging society , the continuous stream of innovative technologies and the growth of chronic illnesses are jeopardizing the sustainability of healthcare systems.
The aging spontaneously hypertensive rats were more vulnerable to AF induction both by S2 stimulation and burst pacing.
The aging-suppressor gene klotho encodes a single-pass transmembrane protein that is predominantly secreted by the choroid plexus of the brain and in the kidney.
The aging U.S. population will approach @percent@ of the total population by @number@
The aging voice can have a significant effect on the quality of life of the patient.
The Agitated Behavior Scale ( ABS ) was the only assessment tool regularly utilized and , therefore , its use was evaluated.
The Ago2-binding gene selenoprotein N1 ( SEPN1 ) was also effectively involved in ATSC survival and self-renewal through ROS-mediated p38 MAPK inactivation.
The agreement between C-G , MDRD , and BIS1 equations was assessed with Bland-Altman analysis.
The agreement between frailty and disability was high with each measure , suggesting that frailty is not simply a pre-disability stage.
The agreement between the responses given by patients and respondents was assessed using Spearman , weighted Kappa and Bland Altman tests.
The agreement between the two tests in identifying acquired red-green and blue-yellow errors was high.
The agreement between this classification and that obtained using BMI calculated by alternative measurements was \ "fair-good. \ "
The agreements between physicians ' and patients ' responses were significant for every single VDSP item.
The agreement was fair to perfect for all items , except for cognitive disorders , undernutrition and polymorbidity ( poor agreement ) .
The agreement was quantified by Cohen's Kappa statistic.
The AID mRNA was not differentially regulated by degradation in aging.
The aids were often issued without discussion with the patient.
The aim here was to determine the impact of hyposalivation and the saliva pH on the quality of life and caries status of geriatrics population.
The aim in talking with a hearing-impaired patient is clarity of communication.
The aim is not , however , to provide a comprehensive systematic review of existing research evidence regarding the older person and disasters.
The aim is to describe the development of a middle-range theory based on coping and adaptation with active aging.
The aim is to identify how many years before death individuals experience a change in the rate of decline of their cognitive ability.
The aim is to survey available methods for adhesion testing and influential parameters affecting experimental outcome.
The aim of LifeLines is to be a resource for the national and international scientific community.
The aim of our investigation is to identify potential associations between brain volume change and POCD in elderly patients undergoing major surgery.
The aim of our observational study was to evaluate , among patients with hip fragility fracture , characteristics and circumstances of falls.
The aim of our present systematic review and meta-analysis was to roundly evaluate the association between AD and its modifiable risk factors.
The aim of our project was to establish an analogous test battery to assess motor function in mice.
The aim of our retrospective cohort study is to analyze the persistence rates in relation to antiosteoporotic drugs using administrative databases in the Campania Region.
The aim of our retrospective study was to identify the causes and methods of management of cobalamin deficiency at Nice geriatric university hospital.
The aim of our review is to present recent findings in phenylketonuria focusing mainly on the adult care.
The aim of our study was first to quantify oxysterol levels in keratinocytes as a function of aging and UV irradiation.
The aim of our study was to assess the age limit from which the test is no longer positive in asymptomatic healthy carriers.
The aim of our study was to evaluate whether genetic variations in AQP-4 gene are associated with the development of LA.
The aim of our study was to examine the validity of these two parameters in CHD classification as used in three different classification programs.
The aim of our study was to explore the age related changes of the fibre type composition of the human psoas major muscle.
The aim of our study was to investigate relative risk factors of HAPR in elderly patients with coronary artery disease.
The aim of our study was to investigate the age-related alterations in Achilles tendons using SE.
The aim of our study was to investigate the role of FcγRs in the pathogenesis of HT.
The aim of our study was to test alteration in balance potentially related to use of acetylcholinesterase inhibitor ( AchEI ) .
The aim of regenerative medicine is to restore or establish normal function of damaged tissues or organs.
The aim of the article is to work out the simple approach for matching of the ages of the human and mammalian.
The aim of the conference was to discuss the progress in the field of neurorecovery.
The aim of the current study was to clarify the association between colorectal cancer ( CRC ) and subsequent risk of being unemployed.
The aim of the current study was to examine if variation in CTSD increases the risk of AD.
The aim of the current study was to examine the association between the course of late-life depression and feelings about God and religious coping.
The aim of the current study was to investigate balance and walking gait in adults with a history of cannabis use.
The aim of the current work was to quantify the ultrasonic properties of the whole breast in vivo as a function of age.
The aim of the present paper is to conceptualize and differentiate these terms and to discuss their interrelations.
The aim of the present research was to study the protective effects and underlying mechanisms of apigenin on d-galactose-induced aging mice.
The aim of the present review is to show the impact of cardiovascular and respiratory conditions on physical function.
The aim of the present review was to address what does measured blood pressure really mean and what are its determinants during the aging process.
The aim of the present review was to help to shed some light on the relationship between IWL and AD.
The aim of the present study is to examine the prevalence of physical frailty in depressed older patients and its potential overlap with depression criteria.
The aim of the present study is to follow several parameters reflecting cell metabolism , antioxidant defences , morphology and membrane dynamics during storage.
The aim of the present study was 2-fold.
The aim of the present study was an in-depth analysis of fine motor skills of the hands in elderly women from different socio-cultural backgrounds.
The aim of the present study was to assess cognitive performance in hemodialysis patients and determine the variables associated with poor cognitive function.
The aim of the present study was to assess the influence of schooling on age-related cognitive decline using unbiased cognitive tests.
The aim of the present study was to assess the psychometric properties of a version in Portuguese of the Reminiscence Functions Scale.
The aim of the present study was to compare the adherence to the PA recommendation using both absolute and relative thresholds.
The aim of the present study was to create reference equations of radial speed of sound ( SOS ) for Central European children and adolescents.
The aim of the present study was to critically compare these four neuropathological staging scales.
The aim of the present study was to elucidate the importance of the preoperative β-cell function in T2DM for the chance of remission after RYGB.
The aim of the present study was to establish a Dutch version of the MCQ and evaluate its psychometric properties.
The aim of the present study was to establish neutralizing monoclonal antibody ( mAb ) against human VASH2 and apply it as an anti-cancer treatment.
The aim of the present study was to evaluate bone and muscle characteristics in children , adolescents , and young adults with MFS.
The aim of the present study was to evaluate , for the first time , the normal values HRM in asymptomatic parous and non-parous women.
The aim of the present study was to evaluate medication appropriateness and frailty among Malaysian aged care home residents with chronic disease.
The aim of the present study was to evaluate the association between periodontitis and long-term medical expenditure in elderly Japanese.
The aim of the present study was to evaluate the three-dimensional morphology of these bodies in the brain in normal aging.
The aim of the present study was to evaluate the validity of the ipsative imputation method using data involving the 15-item Geriatric Depression Scale.
The aim of the present study was to evaluate third molar development and its relation to chronological age using panoramic radiography.
The aim of the present study was to examine the correlation between thoracolumbar curvatures and respiratory function in community-dwelling older adults.
The aim of the present study was to examine the potential interaction of testosterone and APOE genotype with respect to hippocampal volume in middle age.
The aim of the present study was to explore whether collagen degradation causes inhibition of HA synthesis in human skin fibroblasts.
The aim of the present study was to find evidence of a possible decrease of craving in elderly alcohol-dependent patients.
The aim of the present study was to investigate associations between rare TREM2 variants and specific FTD subtypes ( FTD-S ) .
The aim of the present study was to investigate long-term predictors of regular dizziness in older persons.
The aim of the present study was to investigate tau phosphorylation of neurons and astrocytes in the brain of aged dogs with progressive cognitive impairment.
The aim of the present study was to investigate the association between ikigai and incident functional disability among elderly persons.
The aim of the present study was to investigate the neural correlates of feedback processing in risky DM.
The aim of the present study was to investigate whether childhood trauma is associated with long-term DNA methylation alterations in old age.
The aim of the present study was to investigate whether specific clusters of MetS are consistently associated with stiffer arteries in different populations.
The aim of the present study was to provide new original data from a Mediterranean population.
The aim of the present study was to provide normative values for ECAS total score and sub-scores in a sample of Italian healthy subjects.
The aim of the present study was to test to what extent perceived discrimination influences active aging.
The aim of the present work is to describe the overall design of the study.
The aim of the present work was to estimate how non-enzymatic glycation of human serum albumin altered its tertiary structure using fluorescence technique.
The aim of the research was to determine the influence of WBC treatment on the improvement of spine activity in elderly men.
The aim of the research was to study blood responses to pneumonia in patients of different age and sex.
The aim of the study has been to review the various options of treatment , currently available , in the field of phytotherapy.
The aim of the study is to assess the association between WBC and geriatric conditions , CV diseases , and seric IL-6 levels.
The aim of the study is to determine how specific EEG findings during neonatal period correlate with clinical outcome on follow-up.
The aim of the study is to determine the characteristic pattern and frequency of dermatoses in dermatologic patients aged @number@ years and above.
The aim of the study is to elucidate , epidemiologically , associations between mastication and higher brain function.
The aim of the study is to investigate the relationship between the process of aging and the occurrence of LDH in old adults.
The aim of the study was the quantification and functional characterization of the CD56 + monocyte subset in rheumatoid arthritis ( RA ) .
The aim of the study was to analyse the dynamics of growth and weight transitions in a cohort of school children from India.
The aim of the study was to asses functional status elderly people after MAS during early postoperative physiotherapy.
The aim of the study was to assess similarities between aging- and AD-related modifications of gene expression and investigate possible interactions between the two processes.
The aim of the study was to assess the effects of age on the outcome of laparoscopic colorectal surgery for cancer at a single department.
The aim of the study was to assess the food consumption of residents in four French nursing homes depending on diet texture.
The aim of the study was to assess the influence of hypomagnesemia on ED in elderly chronic kidney disease patients.
The aim of the study was to assess the morphologic characteristics of the Achilles tendon in subjects with diabetes in comparison with controls without diabetes.
The aim of the study was to compare telomere length in patients with Parkinson's disease ( PD ) .
The aim of the study was to compare the hemodynamic and nutritional parameters between elderly persons practicing regular physical activity , nonsmokers and ex-smokers.
The aim of the study was to compare the morbidity and mortality of elective and emergent repair.
The aim of the study was to determine the connection between the SOC levels and life satisfaction among the U3A students.
The aim of the study was to determine whether LRA is a valid alternative for coronary angiography compared with RRA in Asian populations.
The aim of the study was to determine whether plasma esRAGE is associated with CKD and is predictive of developing CKD in older adults.
The aim of the study was to determine whether the balance between testosterone and estradiol has any relation to some aspects of sexual function.
The aim of the study was to elucidate whether serum C1q level is associated with aging- and resistance training-induced changes in muscle mass and strength.
The aim of the study was to establish them.
The aim of the study was to evaluate BDNF serum levels in naive elderly depressed patients , before and after antidepressant treatment.
The aim of the study was to evaluate the adherence and efficacy of quetiapine treatment in a 6-month , multicentre , noninterventional naturalistic design.
The aim of the study was to evaluate the progression of and the predictors for calcification in different vascular beds over @number@ years.
The aim of the study was to evaluate the results of an ERAS protocol in older patients that underwent colorectal surgery compared to younger patients.
The aim of the study was to evaluate whether age at the time of evaluation modulates clinical , functional or cognitive profiles in MCI subjects.
The aim of the study was to examine the association between Frank's sign and the development of ischemic stroke.
The aim of the study was to explore perspectives of older Indigenous Australians about their health and wellbeing.
The aim of the study was to identify genetic pathways differentiating phenotypic expression in patients carrying GRN mutations.
The aim of the study was to identify the best combination of clinical and stabilometric tests to predict falls prospectively.
The aim of the study was to investigate a multidisciplinary inpatient treatment with emphasis on hyperthermia therapy by patients with widespread pain.
THE AIM OF THE STUDY was to investigate the comorbidity in patients with a diagnosis of organic depression.
The aim of the study was to investigate the development of a rhythmical skill of children aged from @number@ to @number@ years old.
The aim of the study was to investigate the incidence of the C1367T ( rs1346044 ) polymorphism in patients with age-related cataract.
The aim of the study was to investigate the occurrence and intranuclear distribution of Marinesco bodies in substantia nigra neurons of the human brain.
The aim of the study was to investigate the relationship between functional vision and balance and mobility performance in a community-based sample of older adults.
The aim of the study was to investigate the role of redox balance in the pathogenesis of skin aging in menopausal women.
The aim of the study was to know the main incidents of the adverse reactions in Campo Grande ( MS , Brazil ) .
The aim of the study was to monitor oxidative stress and redox status of both young and old age groups.
The aim of the study was to validate a revised version of Palmore's Facts on Aging Quiz ( FAQ ) .
The aim of the study was to verify which specific physical function measure is a more important predictor of quality of life in these individuals.
The aim of this article is to describe and understand the experience of aesthetic body changes in women between @number@ and @number@ years old.
The aim of this article is to describe the indication , method , and clinical results of PCD.
The aim of this article is to display morphological , histological and molecular biological alterations of the aging eye.
The aim of this article is to provide a general overview of trends impacting the faculty of U.S. dental schools.
The aim of this article is to provide basic recommendation concerning the development and the use of ICT for Alzheimer's disease and related disorders.
The aim of this article is to raise awareness among nurses about frailty and to discuss the recognition and management of this prevailing condition.
The aim of this article is to review the current evidence for the influence of cognitive functioning on sexual behavior in normal aging and dementia.
The aim of this article was to explore age-related differences in the muscle modes ( M-modes ) during voluntary body sway ( VS ) .
The aim of this article was to explore repartnering from the stepfamily's perspective , which has scarcely been studied.
The aim of this article was to investigate the factors contributing to older people's decisions to stop participation in a resistance training program.
The aim of this cross-sectional observational study was to compare the prevalence of domain-specific cognitive impairment between patients with COPD and non-COPD controls.
The aim of this cross-sectional study was to analyze the typical aging process in adults with Down syndrome , focusing on its variability.
The aim of this descriptive study was to determine the cost of management of this disease in the cardiology department at University Hospital of Brazzaville.
The aim of this explorative study was to evaluate this intervention and its implementation.
The aim of this exploratory study was to better understand interpersonal communication between frail elders and caregivers in the context of long-term care giving.
The aim of this guidance is to facilitate clinical research for and with the older patient population.
The aim of this human volunteer study was to evaluate RSSC in relation to ethnicity , gender and age.
The aim of this intervention trial is to identify care needs of people with dementia suffering from pain living in a nursing home.
The aim of this investigation was to assess the influence of microneedles on the skin penetration of peptides using fluorescence imaging to determine skin distribution.
The aim of this investigation was to determine the effects of CR on V˙O2max and muscle strength in the CALERIE trial.
The aim of this investigation was to identify these resources.
The aim of this longitudinal and naturalistic study was to compare aspects of imitative exchanges in dyadic grandmother-infant and mother-infant interactions.
The aim of this meta-analysis was to evaluate evidence for the efficacy of n-3 PUFA in managing overweight and obesity.
The aim of this meta-analysis was to evaluate the association between FAS gene A-670G polymorphism and AD.
The aim of this mini-review is to describe the potential application of surface electromyography ( sEMG ) techniques in aging studies.
The aim of this mini review is to present a risk of carcinogenesis within the prostate related to testosterone treatment.
The aim of this open , multicentric , international study was to assess the efficacy of the combination RAL-HAFi in the correction of skin photoaging.
The aim of this paper is to analyze the elderly patients cohort undergoing neurosurgical procedures and any trend variations over time.
The aim of this paper is to demonstrate the significant effect of the economic cycle on the final accumulated balance in superannuation retirement accounts.
The aim of this paper is to explore some of the factors that underlie this vulnerability.
The aim of this paper is to investigate whether these findings are present also in elderly people.
The aim of this paper is to present an overview of the information available in the current medical literature on presbycusis and presbystasis.
The aim of this paper is to provide estimates of cancer incidence , mortality and prevalence for the Abruzzo and Molise regions combined.
The aim of this paper is to test steepening , applying new data and revised methods.
The aim of this paper was the review the relevant data on the potential role of mitochondria in reproductive aging.
The aim of this paper was to assess whether the metabolic syndrome could be associated to entheseal lesions.
The aim of this paper was to collect and present the most important theories of aging , pointing if possible on reciprocal relationships between them.
The aim of this paper was to evaluate the importance of telomere length assessment for prediction of organ transplantation outcome.
The aim of this paper was to investigate the effect of commercial video games ( VGs ) in physical rehabilitation of motor functions.
The aim of this paper was to review definitions of optimal protein status and the evidence base for optimal dietary protein.
The aim of this pilot study was to evaluate the effect of a task managing training on gait stability.
The aim of this qualitative study is to explore how community-dwelling , older adults living in deprived neighbourhoods address ageing issues.
The aim of this qualitative study was to provide information if and how prostate cancer affects men's daily lives @number@ years after the diagnosis.
The aim of this randomized controlled trial was to determine the effects of 8-week exercise-intervention on cognition and related serum biochemical markers in nonagenarians.
The aim of this report was to analyze the prognostic value of telomere length in men admitted for acute coronary syndrome.
The aim of this report was to characterize the burden of osteoporosis in each of the EU27 countries in @number@ and beyond.
The aim of this report was to characterize the burden of osteoporosis in the EU27 in @number@ and beyond.
The aim of this research was to assess the quality of life in women undergoing radiotherapy for the treatment of breast cancer.
The aim of this research was to examine attitudinal barriers to the employment of Taiwanese older workers ( aged @number@ and above ) .
The aim of this research was to quantify the effect of blade speed and applied thrust force on the volumetric cutting rate of bone cement.
The aim of this review is to characterize recent advances in the genetics of POI and its link with overall health.
The aim of this review is to describe the potential anti-cancer and anti-aging properties of metformin and discuss the possible underlying mechanisms.
The aim of this review is to describe the recent advances in modeling AD using fly and to emphasize some limits of these models.
The aim of this review is to discuss clinical considerations when managing osteoporosis in patients with diabetes.
The aim of this review is to evaluate our current understanding of mechanisms underlying the programming of CVD.
The aim of this review is to examine the interaction between dietary fatty acids and ApoE genotype on the risk for AD.
The aim of this review is to explore more in depth cardiovascular and metabolic disorders associated to KS.
The aim of this review is to give an update on the antibiotic prophylaxis for surgical site infection in elderly people.
The aim of this review is to highlight the main effects of FX on human health.
The aim of this review is to identify enological factors that affect bottle-fermented sparkling wine quality , predominantly aroma , flavor , and foaming quality.
The aim of this review is to outline the involvement of AGEs in the various forms of renal pathology associated with diabetic and non-diabetic nephropathies.
The aim of this review is to provide up-to-date information about phytochemistry , pharmacology , and toxicology of Anemarrhena asphodeloides based on scientific literatures.
The aim of this review is to summarise the evidence linking vitamin D to bone health outcomes in older adults.
The aim of this review is to summarize current literature that shows the involvement of Klotho in the regulation of several intracellular pathways.
The aim of this review is to summarize the available evidence regarding LOH and its interaction with general health.
The aim of this review is to synthesize current evidence to identify the determinants of hearing-aid adoption and use among the elderly.
The aim of this review is to take a deep look into the influence of donor age and in vitro aging on MSC properties.
The aim of this review was to determine whether or not poor PI healing in older adults is a result of suboptimal zinc status.
The aim of this review was to provide an overview and a classification of the filling materials that are most commonly used.
The aim of this review was to systematically evaluate the effect of WBV exposure alone on balance and functional mobility in older adults.
The aim of this secondary analysis was to describe the frequency and nature of patient-physician communication regarding medication cost during glaucoma office visits.
The aim of this short communication is to examine the rationale of a rehabilitation protocol after a vertebral fracture.
The aim of this single-center study was to evaluate the short-term to midterm results after AAA repair in patients > 85 years of age.
The aim of this study is to analyze the factors of affecting prognosis.
The aim of this study is to assess the impact of hearing status on age-related decrease in verbal short-term memory ( STM ) performance.
The aim of this study is to assess the impact on cancer recurrence of a failed laparoscopic attempt.
The aim of this study is to assess the relationship between ART use and utilization of health care services for diabetes and hypertension.
The aim of this study is to assess whether COS for ART may have an impact on mole structure and / or characteristics.
The aim of this study is to calculate risk of death from specific causes for a broader spectrum of dementia diagnoses.
The aim of this study is to clarify contribution of ageing to the development of AA amyloidosis associated with RA in our large cohort.
The aim of this study is to compare both images in the same health control ( HC ) and PD subjects.
The aim of this study is to compare Italian single-centre mid-term outcome in prospective patients treated with LVAD vs. HTx.
The aim of this study is to compare preocclusion , occlusion and postocclusion baseline brachial artery measurements on the calculation of peak FMD.
The aim of this study is to compare these operational models ( i.e. , non-government vs. government-supported funding ) from a cost-benefit perspective.
The aim of this study is to define the basic variables related with criminal behavior among the elderly for cases over @number@ years.
The aim of this study is to describe the association of pet ownership and loneliness.
The aim of this study is to detect survival differences in female breast cancer and identify the main associated factors.
The aim of this study is to determine clinical outcomes associated with class of preinjury anticoagulants ( PA ) used by this population.
The aim of this study is to determine clinical profile of AMD in Nepalese presenting to a Teaching Hospital in Kathmandu.
The aim of this study is to develop and validate effective purification system for PGJ₂ interacting factors ( PGJIFs ) .
The aim of this study is to develop strategies to screen diabetic subjects with isolated postload hyperglycemia ( IPH ) in Chinese population.
The aim of this study is to elucidate the relationship between VEGF , depression , and cognitive impairment in AD.
The aim of this study is to establish the age-related postural changes recorded by the Computerized Dynamic Posturography.
The aim of this study is to establish the method for isolation of prostate cancer-related exosomes from blood.
The aim of this study is to establish the RIs of complete blood cell count for apparently healthy elderly people.
The aim of this study is to evaluate the association between inflammatory aspects of diet and incident AD risk.
The aim of this study is to evaluate the association between physical activity level and physical fitness with erectile dysfunction in men aged 40-75 years.
The aim of this study is to evaluate the efficacy for effectiveness of type A botulinum toxin intradermal injection for facial rejuvenation.
The aim of this study is to evaluate this relationship in older subjects.
The aim of this study is to examine age-related changes within the VAN , focusing on connectivity between its regions.
The aim of this study is to examine older adults ' readiness to relocate to age-appropriate housing versus the wish to stay where they are.
The aim of this study is to examine respondents ' age as a moderator of SRH predictive validity with respect to subsequent mortality risk.
The aim of this study is to examine the outcomes of orthotopic liver transplants from older patients ( > or = @number@ years ) .
The aim of this study is to examine the use of infrared lights in treating facial and body skin laxity.
The aim of this study is to highlight in vivo anatomical and functional changes in early stages of PVD allowing the correct treatment.
The aim of this study is to investigate age-related changes of quantitative diffusivity parameters and fiber characteristics on limbic system in healthy volunteers.
The aim of this study is to investigatethe anti-oxidative activity of Klothoin ox-LDL-treated human umbilical vein endothelial cells ( HUVECs ) .
The aim of this study is to investigate the effects of aging and acid reflux on esophageal motility.
The aim of this study is to investigate the pathogenesis mechanisms and explore as a new potential therapeutic targets for DC.
The aim of this study is to investigate the relationship between personality traits and somatization , and social inhibition.
The aim of this study is to propose a characterization of the viscoelastic properties of the same human muscle in relaxation.
The aim of this study is to provide an extended understanding of the influence of DCCs on family caregivers ( FCs ) .
The aim of this study is to verify whether higher levels of leptin are associated with longitudinal changes of estimated GFR ( eGFR ) .
The aim of this study was the development , characterization and the in vivo effectiveness of RP in non-ionic LCS structures.
The aim of this study was therefore to determine and analyze the willingness to pay ( WTP ) for health insurance among elderly Germans.
The aim of this study was therefore to investigate the influence of RAGE ligands and anti-sRAGE autoantibodies on sRAGE quantification.
The aim of this study was thus to replicate and further elucidate the effect of common genetic variation in WNT16 on osteoporosis related parameters.
The aim of this study was to adapt and to test the reliability of the Polish version of the TFI.
The aim of this study was to analyse blood donor return behaviour.
The aim of this study was to analyse the evolution of strength and muscle mass in women with fibromyalgia along ageing.
The aim of this study was to analyse the relative age effect ( RAE ) in competitive swimming.
The aim of this study was to analyze and compare surgical morbidity associated with third-molar extractions in young and aging populations.
The aim of this study was to analyze BP changes over @number@ years in active elders using ABPM.
The aim of this study was to analyze normal , age-related , metabolic changes in the pons by using turbo spectroscopic imaging.
The aim of this study was to analyze the human orbital asymmetry during development.
The aim of this study was to analyze the interaction effects of aging and leg muscle fatigue on gait parameters in walking and obstacle crossing.
The aim of this study was to answer the question , which endogenous compounds at physiological concentrations can effectively prevent glycation.
The aim of this study was to ascertain the physical activity and nutritional parameters that better predict cardiovascular risk in a cohort of older women.
The aim of this study was to assess age-related changes in the temporal relationship between QT and RR interval variability.
The aim of this study was to assess baseline predictors of how objectively measured physical activity changes with time in older people.
The aim of this study was to assess conditions that influence grip strength in geriatric inpatients.
The aim of this study was to assess differences in nonmotor symptoms between nonmanifesting carriers and noncarriers of the G2019S mutation.
The aim of this study was to assess predictors of bile duct injury using a national database.
The aim of this study was to assess the anti-wrinkle formation efficacy of LF-SQ in subjects.
The aim of this study was to assess the association between MCI and doing housework among old people.
The aim of this study was to assess the association of BP profile with CKD and the presence of cardiac organ damage.
The aim of this study was to assess the association of serum 25-hydroxyvitamin D with exacerbations and mortality in primary care patients with COPD.
The aim of this study was to assess the clinical significance of serum Trx1 level in patients with breast carcinoma.
The aim of this study was to assess the effectiveness of a Guided Walking Program in a high social vulnerability context.
The aim of this study was to assess the levels of flexibility , functional autonomy and QoL in elderly yoga practitioners.
The aim of this study was to assess the molecular , histological , morphological and microflora alterations of GI tract in male Alzheimer's transgenic mice.
The aim of this study was to assess the potential for n-butylidenephthalide to improve PD in C. elegans models.
The aim of this study was to assess the prevalence of hormonal disorders in women with acne resistance to conventional therapy.
The aim of this study was to assess the prevalence of PIMs among Lebanese aged outpatients using Beers criteria of @number@
The aim of this study was to assess the relationship between TRT and prostate cancer.
The aim of this study was to assess the significance of the variable Jung in non-infarction patients with acute pulmonary edema.
The aim of this study was to assess the validity and reliability of the Persian version of SASS ( P-SASS ) for older adults.
The aim of this study was to assess the visual impact on the skin of repeated ultraviolet-A ( UVA ) exposure through a window.
The aim of this study was to assess time trends in benzodiazepine use.
The aim of this study was to assess whether serum levels of FFAs are associated with long-term prognosis in subjects with stable coronary heart disease.
The aim of this study was to better understand the cortical mechanisms underlying the interaction between pain and the motor system.
The aim of this study was to characterise the therapies offered by online stem cell clinics.
The aim of this study was to characterize anandamide breakdown in physiological and pathological aging and its regulation by CB1 and CB2 receptor agonists.
The aim of this study was to characterize the spatial and temporal patterns of resting state neuronal synchronizations in primary progressive aphasia syndromes.
The aim of this study was to clarify how age and gender influence LAP and its relation to diabetes.
The aim of this study was to clarify the longitudinal relationship between hypotension and incident LLD.
The aim of this study was to clarify the role of uPAR on the development of adipose tissue.
The aim of this study was to compare attitudes about depression in primary care practices in South Korea , Russia , and the USA.
The aim of this study was to compare conventional laryngeal mask airway sizing by weight with sizing by age in over- or underweight children.
The aim of this study was to compare intracellular and extracellular magnesium concentrations in geriatric outpatients.
The aim of this study was to compare MUC1 expression level in oral mucosal epithelial cells of the elderly with that of young adults.
The aim of this study was to compare ovarian ageing between girls born appropriate for gestational age ( AGA ) and SGA.
The aim of this study was to compare the effects of exercise training on arterial stiffness between older hypertensive and healthy females.
The aim of this study was to compare trends in osteoporosis preventive practices between veteran and nonveteran older adults.
The aim of this study was to correlate donor age and the patterns of ischaemia reperfusion injury and synthetic function early after liver transplantation.
The aim of this study was to define age-related trends including sex differences based on reliable data.
The aim of this study was to describe supplement use among Icelandic older adults and to assess its association with total mortality and CVD-related mortality.
The aim of this study was to determine how sex hormone levels and the AR polymorphism relate to depressive symptoms in aging men.
The aim of this study was to determine if aging is associated with enhanced endothelial progenitor cell ( EPC ) sensitivity to apoptosis.
The aim of this study was to determine if CS activates complement and if the antioxidant transcription factor Nrf2 modulates this response.
The aim of this study was to determine if those changes can be detected automatically and used to prevent false positive flagging.
The aim of this study was to determine the association of hormone levels with the occurrence of musculoskeletal pain.
The aim of this study was to determine the course of thyroid function over @number@ years in a population with normal thyroid function.
The aim of this study was to determine the diagnostic value of the recently identified candidate PC biomarker HIST1H4K.
The aim of this study was to determine the effect of age on the COP trajectory during barefoot gait at a self-selected speed.
The aim of this study was to determine the effect of aging on ICC number and volume in the human stomach and colon.
The aim of this study was to determine the effect of a treatment based on aerobic exercise in institutionalised elderly people diagnosed with knee osteoarthritis.
The aim of this study was to determine the frequency and spectrum of mutations in MATR3 in a Taiwanese ALS cohort of Han Chinese origin.
The aim of this study was to determine the impact of benzodiazepine use on cognitive functions in a young adult population.
The aim of this study was to determine the predictors of DKA in children with newly diagnosed type @number@ diabetes mellitus ( T1DM ) .
The aim of this study was to determine the prevalence of ICDs among elderly patients and to evaluate the related sociodemographic and clinical features.
The aim of this study was to determine the relative contributions of MLCK and ROCK to carbachol-induced contraction of human detrusor smooth muscle in vitro.
The aim of this study was to determine the response of central hemodynamics during the BFR exercise to assess its impact on cardiac load.
The aim of this study was to determine the universality and the clinical utility of GA in screening for diabetes mellitus.
The aim of this study was to determine whether and how baicalein can act as an antioxidant.
The aim of this study was to determine whether articles on delirium among medical inpatients proved sudden onset and rapid recovery.
The aim of this study was to determine whether functional IL-6 promoter -174G / C ( rs1800795 ) polymorphisms confer susceptibility to knee OA.
The aim of this study was to determine whether high protein intake was associated with declines in kidney function among older patients.
The aim of this study was to determine whether the effects attributed to aging on cardiovagal and sural nerve function decline are associated.
The aim of this study was to determine whether this policy shortens the DCD donors ' life.
The aim of this study was to develop a new procedure for evaluating effortful inhibition on the basis of the comprehension of metaphors.
The aim of this study was to enhance our understanding of age-related changes in the functional architecture of these circuits.
The aim of this study was to establish age-related reference values for distensibility and wall stiffness index of the ascending aorta.
The aim of this study was to establish normative data for IVA at the lateral tricuspid valve annulus ( RV IVA ) .
The aim of this study was to estimate the prevalence of attempted suicide in the elderly and examine the associated factors.
The aim of this study was to evaluate age-related morphological canal changes in mesial root canals of mandibular first molars of known ages.
The aim of this study was to evaluate associations between bone mineral density ( BMD ) and As exposure in men subjects.
The aim of this study was to evaluate cortical thickness in former professional soccer players using high-resolution structural MR imaging.
The aim of this study was to evaluate different veneering approaches for zirconia single crowns regarding contact wear , fracture strength , and failure mode.
The aim of this study was to evaluate early cardiac abnormalities in obese youth and the potential association with insulin resistance ( IR ) .
The aim of this study was to evaluate efficacy and safety of low-dose oral prolonged-release oxycodone-naloxone ( OXN-PR ) in patients aged ≥70 years.
The aim of this study was to evaluate forearm and foot weight bearing using a FWW-AR and the effect of the armrest height.
The aim of this study was to evaluate perinatal cardiovascular changes in ventricular geometry and myocardial performance in normal term fetuses.
The aim of this study was to evaluate swallowing dysfunction and carbonated liquid using videofluoroscopy in DLB and PDD patients.
The aim of this study was to evaluate symptoms of premature aging in women of young age with central hypogonadism.
The aim of this study was to evaluate the association between persistent organic pollutants ( POPs ) and thyroid hormones in an aging population.
The aim of this study was to evaluate the association between total testosterone and incident T2DM in a large population-based cohort.
The aim of this study was to evaluate the association of depressive symptoms with hospitalization and mortality rates in a general unselected older population.
The aim of this study was to evaluate the carotid arterial intima-media thickness ( IMT ) and its relation to clinical parameters in Japanese children.
The aim of this study was to evaluate the effect of age on the relationship between BSP and CSP measured after exercise.
The aim of this study was to evaluate the effect of cynical distrust on mortality in middle-aged and aging men.
The aim of this study was to evaluate the effect of this ban on hospital admissions for ischemic heart disease ( IHD ) .
The aim of this study was to evaluate the effects of high-intensity exercise on antioxidant vitamins in non-professional runners with varying levels of aerobic power.
The aim of this study was to evaluate the efficacy and safety of SVC technology , based on the principle of separate biological responses.
The aim of this study was to evaluate the efficacy and safety of urological surgeries in old patients.
The aim of this study was to evaluate the influence of partial-retainer design on the failure load of selective infiltration-etched zirconia restorations.
The aim of this study was to evaluate the operative risks of LR in the elderly.
The aim of this study was to evaluate the vitamin D status and the prevalence of vitamin D deficiency in an urban Korean population.
The aim of this study was to evaluate this hypothesis in healthy octogenarians.
The aim of this study was to evaluate this screening protocol in relation to clinical outcomes and management.
The aim of this study was to evaluate whether C. rotundus extract and its constituents can inhibit this channel.
The aim of this study was to evaluate whether ginger and its pungent constituents modulate these channels and exert antioxidant effects.
The aim of this study was to evaluate whether sleep deprivation affects the integrity of DNA in skin and exacerbates the effects of aging.
The aim of this study was to evaluate whether the postmenopausal ovary is hormonally active and whether hormone status contributes to lipid metabolism.
The aim of this study was to examine and compare the effects of different resistance training protocols on bone marker concentrations in older men.
The aim of this study was to examine outcomes of perioperative rehabilitation intervention for patients who underwent lumbar decompression surgery ( LDS ) .
The aim of this study was to examine physiological , perceptual , and affective responses during self-paced walking for three age groups.
The aim of this study was to examine potential associations between exercise and lowering the risk of cognitive impairment.
The aim of this study was to examine the agreement between the IE and validated observational pain tools.
The aim of this study was to examine the association between indoor mobility-related fatigue and muscle strength decline in nonagenarians.
The aim of this study was to examine the association between socio-demographic and health-related factors and cognitive impairment in the elderly in Taiwan.
The aim of this study was to examine the barriers and facilitators of service use among family caregivers of people with dementia.
The aim of this study was to examine the differences in food intake among older community-dwelling adults with different reported appetite levels.
The aim of this study was to examine the effectiveness of exercise in these three diseases.
The aim of this study was to examine the effect of aging and training status on ventilatory response during incremental cycling exercise.
The aim of this study was to examine the effect of aging on strategy selection in a paired-associate word task.
The aim of this study was to examine the health related quality of life of old people living in Bandar Abbas , Iran.
The aim of this study was to examine the impact of age on the perceptions of mental and physical health in an Australian population.
The aim of this study was to examine the moderating role of gender on relations among social support functions and life satisfaction in older Malaysians.
The aim of this study was to examine the relation between UI and cognitive function among non-disabled middle-aged and elderly community-dwelling people.
The aim of this study was to examine the relationship between mutation status and cognitive and motor functioning in a sample of community-dwelling older adults.
The aim of this study was to examine the relationships between apathy and perceived self-efficacy.
The aim of this study was to examine tissue turnover in cartilage affected by ochronosis and its role in disease initiation and progression.
The aim of this study was to examine whether an optimistic outlook predicts survival among the oldest-old.
The aim of this study was to examine whether cerebellar and brainstem changes emerge during development or aging in late life.
The aim of this study was to examine whether ET is associated with Purkinje cell ( PC ) loss.
The aim of this study was to examine whether high subjective wellbeing is associated with a lower risk of developing COPD.
The aim of this study was to examine whether mild cognitive impairment ( MCI ) and slow gait are associated with the serum IGF-1 level.
The aim of this study was to examine whether performance on phonemic and semantic fluency tasks follows similar lifespan trajectories.
The aim of this study was to explore experiences of self-determination when developing dependence in daily activities among community-dwelling persons @number@ years and older.
The aim of this study was to explore personal preferences of potential patients regarding life-prolonging neurosurgical interventions by interviewing ambulatory , autonomous elderly people.
The aim of this study was to explore the association between BDNF promoter methylation and MCI in the Xinjiang Uygur and Han populations.
The aim of this study was to explore the association of dietary and lifestyle patterns with MCI among elderly people in Beijing.
The aim of this study was to explore the incidence trends and the age distribution of CRC by subsite in Guangzhou between @number@ and @number@
The aim of this study was to explore the influence of disability on attempted suicide within this demographic.
The aim of this study was to explore the perspectives of a range of service providers involved in mealtime management in residential aged care.
The aim of this study was to explore the prevalence of vitamin D deficiency and its association with mortality.
The aim of this study was to explore the relationship between use of dopamine agonists and the risk of heart failure.
The aim of this study was to explore the relative contribution of worry and physical symptom frequency to clinical significance associated with late-life GAD.
The aim of this study was to explore the views of older people with UI on the process of seeking help.
The aim of this study was to explore whether abilities in six different cognitive domains could predict LS in the oldest-old @number@ years later.
The aim of this study was to find those mechanical skin parameters best representing influence of aging at five different body sites.
The aim of this study was to further investigate whether DLA-M regulates intestinal absorption and gut microbiota to prevent obesity-related metabolic disorders.
The aim of this study was to identify acoustic measures , particularly LTAS's , which characterize vocal aging in women without vocal complaints.
The aim of this study was to identify new factors predictive of rupture.
The aim of this study was to identify significant sociodemographic predictors of psychological well-being among Malay elders.
The aim of this study was to investigate age-related differences in dual task performance by using an upper limb proprioceptive task.
The aim of this study was to investigate aging-related alterations of midfacial fat thickness ( FT ) using computed tomographic images.
The aim of this study was to investigate associations between lifestyle factors and high CRP among middle-aged men living in Shanghai , China.
The aim of this study was to investigate circadian rhythmicity of serum cholesterol concentrations in offspring of nonagenarian siblings and their partners.
The aim of this study was to investigate differences in the brainstem volume and shape between patients with AD and elderly normal controls.
The aim of this study was to investigate longitudinal cortical microstructural changes in PD with quantitative T1 relaxometry.
The aim of this study was to investigate patient outcomes after hospitalization for out-of-hospital cardiac arrest in the United States.
The aim of this study was to investigate possible changes in the membrane skeleton of these RBCs and to compare them with pathological RBCs.
The aim of this study was to investigate sex-specific differences in gait among older adults.
The aim of this study was to investigate socioeconomic inequalities for all-cause , cardiovascular and dementia mortality among the people aged @number@ or older.
The aim of this study was to investigate solid organ cancer incidence among subjects on the waiting list at a single center.
The aim of this study was to investigate the age-association and regional differences of histomorphometric properties in the femoral neck cortical bone.
The aim of this study was to investigate the association between p22phox C242T single nucleotide polymorphism and aging in Turkish population.
The aim of this study was to investigate the association of body composition and functionality with metabolic syndrome in the elderly.
The aim of this study was to investigate the association of early sub-clinical cognitive decline with CBF.
The aim of this study was to investigate the associations between CB ( level and change ) and SMC over a 10-year span.
The aim of this study was to investigate the benefits of home-based rocking-chair training , and its effects on the physical performance of elderly women.
The aim of this study was to investigate the dietary intake in elderly people in two types of living situations.
The aim of this study was to investigate the effect of age on supra-sternal USCOM scan repeatability during anaesthesia.
The aim of this study was to investigate the effect of a member of this cluster , miR-17 , on cardiac senescence.
The aim of this study was to investigate the effect of tau mutation on the retina using a transgenic tau P301L mouse model.
The aim of this study was to investigate the effects of age on hemispheric asymmetry in the auditory cortex after pure tone stimulation.
The aim of this study was to investigate the effects of curcumin from the rhizome of Curcuma longa on appoptosin-induced apoptosis in SH-SY5Y cells.
The aim of this study was to investigate the effects of different cognitive challenges on handgrip fatigue with aging.
The aim of this study was to investigate the effects of hybrid training on glucose metabolism and serum IL-6 levels in elderly people.
The aim of this study was to investigate the effects of knee or hip OA on physical performance during a follow-up period of @number@ years.
The aim of this study was to investigate the feasibility of the definitive surgery for the acute subarachnoid cases aged @number@ or older.
The aim of this study was to investigate the impact of age and other covariates on the rate of GE.
The aim of this study was to investigate the impact of CIMP on CRC survival in a large population-based study with comprehensive adjustment.
The aim of this study was to investigate the impact of these factors on early outcomes in patients aged ≥85 years with acute STEMI.
The aim of this study was to investigate the influence of aging on electrogastrograms ( EGGs ) .
The aim of this study was to investigate the long-term effect of protracted ionizing radiation exposure on telomere length in CNPP clean-up workers.
The aim of thisstudywas to investigatethe myoelectrical signal ofknee jointmusclesin different agestages during upright standing.
The aim of this study was to investigate the neuronal network characteristics in physiological and pathological brain aging.
The aim of this study was to investigate the potential effects of cardiac function on CBF.
The aim of this study was to investigate the prevalence and factors related to alcohol consumption among older adults in China and Norway.
The aim of this study was to investigate the prevalence of diabetes in Icelandic nursing homes over the period 2003-2012.
The aim of this study was to investigate the prevalence of late-onset hypogonadism ( LOH ) in population of Polish men with prediabetes.
The aim of this study was to investigate the prevalence of prediabetes in population of Polish men with late-onset hypogonadism ( LOH ) .
The aim of this study was to investigate the quantity of 5hmC containing nuclei by immunohistochemistry in human and murine brains at several developmental stages.
The aim of this study was to investigate the relationship between bone area and indices of carotid and peripheral atherosclerosis.
The aim of this study was to investigate the relationship between clinical parameters in GDM and variants in genes involved with nutrients and metabolism.
The aim of this study was to investigate the relationship between lipoprotein subclasses and brachial-ankle PWV ( baPWV ) .
The aim of this study was to investigate the relationship between serum ferritin levels and bone mineral density ( BMD ) in elderly Koreans.
The aim of this study was to investigate the relationship of aging and malnutrition to innate immune functions in tube-fed bedridden patients.
The aim of this study was to investigate the relationships between contrast sensitivity , RNFL thickness , HIV infection and frailty in South African adults.
The aim of this study was to investigate the reliability of new automated oscillometric measurement of eA and V ( E ) .
The aim of this study was to investigate the role of age-related IL-17 dysregulation in prostate tumorigenesis.
The aim of this study was to investigate the role of cytochrome P450-2E1 ( CYP2E1 ) in aging-dependent kidney damage since it is poorly understood.
The aim of this study was to investigate the role of dermal CD271 + cells in wound healing.
The aim of this study was to investigate these mechanisms in terms of effective connectivity by application of dynamic causal modeling with Bayesian Model Selection.
The aim of this study was to investigate the top cancers that affect centenarians.
The aim of this study was to investigate the transferability of these algorithms in people with Parkinson's disease ( PD ) .
The aim of this study was to investigate whether AD patients present with a different CMV-specific CD8 immune profile compared to non-demented controls.
The aim of this study was to investigate whether psychosocial resources modify the effects of frailty on functional decline and mortality.
The aim of this study was to investigate whether sequence variations of SIRT6 are associated with aging and longevity in Finnish men.
The aim of this study was to measure olfactory ability in patients with TEA and explore whether olfactory symptoms relate to other clinical variables.
The aim of this study was to observe age-related changes of sodium currents between pediatric and adult atrial myocytes.
The aim of this study was to obtain information about clinical characteristics which might predict the HbA1c response to DPP-4 inhibitors.
The aim of this study was to perform a meta-analysis investigating the relationship between SPPB score and all-cause mortality.
The aim of this study was to qualify natural skin wrinkles as potential anatomical markers of carotid artery bifurcation and scar camouflage.
The aim of this study was to quantify the effect of frailty on glomerular filtration of drugs , using the probe drug gentamicin.
The aim of this study was to quantitatively analyse a number of morphometric parameters of the ageing oral mucosa.
The aim of this study was to quantitatively summarize the evidence for the MTHFRC677T polymorphism and ALL risk.
The aim of this study was to report our experience with cemented percutaneous screws in the management of patients with a poor bone stock.
The aim of this study was to report persistence of ReGS despite clitoridectomy.
The aim of this study was to see whether this relationship differs for M-type seniors , as compared to seniors outside the M-type category.
The aim of this study was to standardise the CRT method outcomes for age and gender effects.
The aim of this study was to study the variation in foveal bulge with age.
The aim of this study was to summarize the literature on CVD risk among Arctic Inuit.
The aim of this study was to systematically explore the relationship between these two platelet serotonin parameters in large human population.
The aim of this study was to test if variants in the TMEM230 gene are associated with PD in @number@ independent American European data sets.
The aim of this study was to test this hypothesis by examining whether individual physiological responses to odors could predict the subject's nutritional status.
The aim of this study was to understand the experience of home as experienced by older adults living in a rural community in Sweden.
The aim of this systematic literature review was to identify the neurocognitive markers associated with suicide vulnerability in elderly people.
The aim of this systematic review is to evaluate the role of enteral nutrition in dementia.
The aim of this systematic review is to evaluate the role of the Tregs in immunosenescence.
The aim of this systematic review was to examine factors that influence adherence to cancer treatment in older adults with cancer.
The aim of this systematized review was to describe the association between depression and QOL in older adults with visual impairment.
The aim of this trial was to evaluate , through ultrasound imaging , the long-term effects of microinjections of HA on SLEB echogenicity.
The aim of this viewpoint article is threefold.
The aim of this work is the adaptation and validation of the Person-centered Care Assessment Tool ( P-CAT ) for a Spanish population.
The aim of this work was the study of indicators of memory and intellectual activity among the elderly with different reading productivity.
The aim of this work was to assess the effect of age and severity of CDS on social responsiveness.
The aim of this work was to assess whether the antioxidant status of RBC changes in aging and AD.
The aim of this work was to develop a score for frailty in experimental animals based in the human frailty phenotype.
The aim of this work was to validate the hypothesized involvement of IL-23A and its receptor in IDD.
The aims are ( @number@ ) to describe SPPB distribution before hospital discharge and ( @number@ ) to investigate the prognostic role of SPPB score.
The aims of present study were to evaluate the prevalence , risk factors , and prognostic significance of masked hypertension in diabetic patients.
The aims of the study were to assess the change in nutritional status during hospitalization and determine if its decline is associated with prolonged LOS.
The aims of this article are to define the term heatwave and identify the normal thermoregulatory responses to hot weather.
The aims of this report were to assess the prevalence and clinical significance of vitamin C deficiency among hospitalized acutely-ill older patients.
The aims of this review are threefold.
The aims of this study were to determine the age effects on upper limb kinematics and establish norms in healthy children.
The aims of this study were to determine the association between midlife physical activity and late-life disability and to investigate gender-specific differences.
The aims of this study were to gather in-depth information on the concerns of lesbian and gay elders with respect to aging and care needs.
The aim was also to explore factors associated with risk of falling.
The aim was to determine the ergonomic and functional requirements of such devices and to include these requirements in a user-centered development process.
The aim was to determine the relationship of vitamin B12 levels in serum with metabolic parameters and the possibility of correction using gerodietetic meat pate.
The aim was to determine whether depressive symptoms are also associated with greater structural knee OA progression.
The aim was to develop a small-scale affordable and transportable simulation device that allowed transferring effects to a full-scale device involving actual walking.
The aim was to develop the PRISCUS-PAQ and test the reliability in community-dwelling people ( ≥70 years ) .
The aim was to evaluate cVEP in children with red-green congenital colour vision deficiency.
The aim was to examine grocery purchasing behaviour in relation to chewing ability , dietary knowledge and socio-economic status ( SES ) among older adults.
The aim was to examine trend in MSK as underlying cause of death in @number@ countries across globe during 1986-2011.
The aim was to explore the relationship of neighborhood characteristics with metabolic conditions in older women.
The aim was to find candidate biomarkers able to discriminate between mTBI and sTBI.
The aim was to identify and validate several immune cell function parameters as markers of biological age.
The aim was to identify brain-based predictors for initiation of alcohol use and onset of future substance use disorders.
The aim was to increase students ' understanding of some of the issues surrounding disability and what this means to individual patients.
The aim was to investigate attitudes towards parenthood , intentions for childbirth and knowledge about fertility issues among men and women.
The aim was to investigate BMI and PA tracking over @number@ years from youth to adulthood.
The aim was to investigate if socioeconomic position was associated with antipsychotic drug treatment among older adults with and without dementia.
The aim was to investigate the impact of enriched environment at work on the incidence of dementia.
The aim was to investigate the influence of various biological factors upon the outcome of intrauterine insemination ( IUI ) .
The aim was to provide insights of relevance to the development of future efforts to optimise seniors ' food shopping experiences and nutrition-related outcomes.
The aim was to re-evaluate the existing state of hemotherapy , identify areas where further studies are needed , and to provide up-dated recommendations.
The aim was to study if the chromosomal pattern in TS women changes over time.
The aim was to study metamemory during encoding in older schizophrenia patients.
The aim was to undertake a systematic review of the existing research literature on dysmobility syndrome.
The air leaks were stopped in @number@ cases except for @number@ case.
The air quality in this area was determined to be grade I with high negative oxygen ion content and low SO2 and inhalable particle contents.
The airway is wider anteroposteriorly and narrows in the transverse dimension from the subglottis to the cricoid in infants.
The Akt kinase regulates processes of cellular proliferation and survival.
The AKT-signaling pathway , thought to mediate the effect of DJ-1 on cell survival , was also altered.
The albumin levels and variability were negatively correlated with each other and exhibited exactly opposite movements throughout the course of chronic HD treatment.
The ALCCs were determined manually via SD-OCT.
The aldicarb hypersensitivity can be rescued by full length APL-1 in a dose dependent fashion.
The alexithymia features in patients with mild Alzheimer's disease and mild cognitive impairment did not significantly differ ( p > @number@ for all ) .
The ALFF method was applied to evaluate spontaneous brain activity.
The algal intracellular hemolytic toxicity averaged about @percent@ at different algal growth phases.
The algorithm had a correlation of @number@ with the average of graders and @number@ with each of the graders individually.
The algorithm has the potential to benefit older adults with SNHL who struggle to communicate via the telephone with or without hearing aids.
The allele frequencies of rs7895833 and rs7069102 , which are different from Caucasians , might explain why Japanese show less marked obesity compared with Caucasians.
The alleles of PvuII polymorphism were defined as T and C : heterozygote TC , homozygote TT , and wild type CC.
The alleles of the XbaI polymorphism were defined as A and G : heterozygote AG , wild type GG and homozygote AA.
The Allergic Rhinitis and its Impact on Asthma ( ARIA ) initiative commenced during a World Health Organization ( WHO ) workshop in @number@
The allometric model was developed from adult data and then the model was used to predict clearance of the coagulation factors in individual child.
The allopurinol response is highly variable , with many users failing to achieve target serum uric acid ( SUA ) levels.
The all-time top @number@ American film villains and heroes were obtained from the American Film Institute @number@ Greatest Heroes and Villains List.
The alpha2 band decreased in the young , while the delta band increased in the elderly in the task condition.
The alphaviruses , Barmah Forest and Ross River , accounted for @number@ ( @percent@ ) of these notifications during @date@ .
The alpha ( α ) long-range scaling coefficient derived from DFA and gait speed were evaluated as outcomes.
The ALSA data are held at the Flinders Centre for Ageing Studies , Flinders University.
The alteration of RAP1GAP mRNA levels may explain the clinical variability of GRN-FTLD patients.
The alterations in the levels of these parameters correlated significantly with the total antioxidant capacity of the plasma.
The alterations of myocardial connexin are well established as a consistent feature of both human and animal heart disease and aging.
The alterations undergone by the mitochondrial proteome revealed aging- and T2DM-specific hallmarks.
The alterations were quite important in the color , MSM and rheological functions of the skin.
The altered balance between ROS generation and elimination plays a critical role in a variety of pathologic conditions including neurodegenerative diseases , aging and cancer.
The altered dynamics of CD44 in the cell membrane demonstrated a further action of miR-7 in regulating the HA-dependent CD44 / EGFR pathway.
The altered taste perception was associated with decreased levels of key taste regulatory molecules in the tongue epithelium.
The altered transfer of CBF to cortical oxygenation in AD indicates that properties of the cerebral microvasculature are changed in this disease.
The Alzheimer BACE1 enzyme cleaves numerous substrates , with largely unknown physiological consequences.
The Alzheimer Cohorts Consortium aggregates data from nine international population-based cohorts to determine changes in the incidence of dementia since @number@
The Alzheimer's Association and the Alzheimer's Drug Discovery Foundation convened a one-day workshop to delve into this discussion.
The Alzheimer's Disease Neuroimaging Initiative recently implemented accelerated T1-weighted structural imaging to reduce scan times.
The ambiguity is primarily related to sarcopenia , the progressive loss of muscle and gain in fat that come with aging.
The ambiguous nature of the human condition of discogenic low back pain motivates the use of animal models to better understand the pathophysiology.
The ambulatory arterial stiffness index ( AASI ) is a proposed indicator of arterial stiffness easily calculated from ambulatory blood pressure.
The aMCI group also exhibited altered regional convergence degree in the right inferior parietal lobule.
The aMCI participants were impaired on the Simon task when working memory was required , but conflict resolution was similar to controls.
The AMD-associated risk haplotype ( T-in / del-A ) impairs the ability of the RPE to defend against aging-related oxidative stress.
The a-md-MCI group showed a significant power increase within delta and theta ranges and reduced relative power within alpha and beta ranges.
The AMD test required subjects to respond verbally to queries regarding whether or not they detected arm motions.
The amelioration of age-associated phenotypes by epigenetic remodeling during cellular reprogramming highlights the role of epigenetic dysregulation as a driver of mammalian aging.
The American College of Obstetricians and Gynecologists ' Committee on Gynecologic Practice endorses the joint document and encourages its use by Fellows.
The American Medical Association ( AMA ) developed an evidence-based , multi-media Curriculum to promote basic competences.
The American Medical Association Current Procedural Panel developed a new billing code making behavioral health screening a reimbursable healthcare service.
The American Occupational Therapy Association ( AOTA ) Evidence-Based Practice Project has developed a table summarizing the research opportunities in the area of productive aging.
The American Occupational Therapy Association's Centennial Vision articulates the strategic goals for the profession to be science driven and evidence based in major practice areas.
The AMH levels were higher among African American compared with Latina and Chinese women at older ages.
The amine-terminated SiNPs showed no significant cytotoxic effects toward HepG2 cells , as assessed with MTT assays.
The amount of adipose tissue in abdominal and thigh depots may also convey risk beyond BMI.
The amount of available food is one of these parameters.
The amount of each nutrient per @number@ kcal was calculated to determine whether there were trends in product reformulation.
The amount of family contact was examined with descriptive statistics.
The amount of Gd precursor can be well-controlled to realize the optimized balance between the MR relaxivity and optical properties.
The amount of home-help services used did not reflect cognitive severity , suggesting that home help did not meet the needs related to cognitive deterioration.
The amount of information was rated as just right ( @percent@ ) , but the tool had limited space for responding ( @percent@ ) .
The amount of light received during the nighttime influenced sleep more significantly than during the daytime.
The amount of melanin and lipofuscin granule and drusens were noted.
The amount of membrane cholesterol may play an important role both in protecting neuronal cells against toxic insults and in inhibiting the production of β-amyloid.
The amount of Ni element can be increased in the urine of patients who have experienced broken endodontic instrument inside the dental canal.
The amount of shuttle craft transcript appeared to be substantially decreased in mutant embryos.
The amount of sleep declines with aging and to a greater extent in AD.
The amount of slow wave sleep obtained was not determined to be important.
The amount of stem cells did not affect the increase in collagens.
The amount of total cost health care throughout the life of a stroke patient is calculated at €43 , 129.
The amounts of CML in raw and cooked butters were @number@ ± @number@ and @number@ ± @number@ μg / g , respectively.
The amounts of elastic fibers and proteoglycans were assessed by Elastica-Masson staining and alcian blue staining , respectively.
The amounts of pattern types are different : @date@ is increased and 2LV and 2ULV are reduced in the old group.
The amounts of reactive persulfides and polysulfides in the lung cells had a positive correlation with the degree of airflow limitation.
The amounts of subarachnoid blood , microthrombi , apoptosis and degenerative neurons were compared.
The amounts of synthases in the lung tissues , sputum and primary cells were quantified.
The AmpFLSTR® Identifiler® Plus kit , which targets @number@ STRs , is commonly used worldwide.
The amplitude of component N2 is above at the account of sounds in both age groups.
The amplitude of optimal stimulus for improving balance performance was predominantly in the range of ±100 to ±400 μA.
The amplitude of pattern ERG was significantly reduced , although dark-adapted and cone ERGs showed no impairment , in 24-week-old SOD1-deficient mice.
The amplitude of this component negatively correlated with go-RTs.
The amplitude ratio was neither correlated with the degree of endolymphatic hydrops nor with the duration of disease.
The amplitudes of the LFOs were generally higher in young adults than in the elderly and increased significantly only in the younger subjects after HUT.
The amplitudes of tongue-palate pressure or submental sEMG did not differ when swallowing barium versus nonbarium stimuli.
The amplitude-time parametres of component P300 do not differ at examinees of different age in a problem of listening of sounds.
The AMPS can be used internationally to evaluate ADL performance in children and to determine if the child is eligible for occupational therapy services.
The amygdala has also been implicated in mood and anxiety disorders which display sex-specific features , most prominently observed during adolescence.
The amygdalar nucleus showed the greatest involvement , with over @percent@ local tissue reduction.
The amyloid cascade hypothesis of Alzheimer's disease ( AD ) posits that the generation of β-amyloid ( Aβ ) triggers Tau neurofibrillary pathology.
The amyloid fibrils were composed of full-length apoA-I with differential oxidation of the three methionines.
The amyloid hypothesis of Alzheimer's disease posits that the excessive accumulation of amyloid-β peptide leads to neurofibrillary tangles composed of aggregated hyperphosphorylated tau.
The amyloid hypothesis suggests that beta-amyloid ( Aβ ) deposition leads to alterations in neural function and ultimately to cognitive decline in Alzheimer's disease.
The amyloid volume density correlated inversely with the β-cell volume density but not with the body mass index in the eT2DM group.
The amyloid-β ( Aβ ) peptide has come into focus and is believed to be central to the pathogenesis of Alzheimer's disease.
The amyloid β ( Aβ ) protein is a major component of senile plaques , one of the neuropathological hallmarks of Alzheimer's disease.
The anabolic effect of food intake was measured by studying the volunteers both at the post-absorptive and post-prandial states.
The analgesic and anti-inflammatory effects of NSAIDs are COX-2-dependent effects , unrelated to COX-2 selectivity.
The analgesic and anti-inflammatory effects of NSAIDs are dependent on the extent and duration of COX-2 inhibition in the spinal cord and inflammatory sites.
The analgesic effect of this method was tested in this study during facial dermal filler injections.
The analog-based free testosterone value can be considered instead as a suitable biochemical determinant for diagnosing late-onset hypogonadism syndrome.
The analog-based free testosterone values were approximately @percent@ of the calculated free testosterone values.
The analyses also indicated different effects on inpatient care depending on educational level.
The analyses also showed that age was correlated with FMDTs only.
The analyses are conducted in two steps.
The analyses demonstrate how decline in resistance to stresses and adaptive capacity accompanying human aging can be evaluated from longitudinal data.
The analyses focus on availability and receipt as the two primary dimensions of intergenerational support relationships.
The analyses have been adjusted for age and gender.
The analyses identified new rare variants in chromosomes @number@ and @number@ associated with extreme survival and with reduced risk for cardiovascular disease and Alzheimer's disease.
The analyses include descriptive statistical data , gender differences and correlation matrices.
The analyses included @number@ adults ( mean age @number@ years ; @number@ % men ; @number@ % ever asthma ) .
The analyses of genetic effects in age-matched samples suggest a role of environmental and age-related mechanisms in the associations of different SNPs with TC.
The analyses of several discrimination parameters ( d ' and probability of recognition ) and the response criterion yielded significant age differences.
The analyses of the data were performed according to inductive thematic analysis.
The analyses presented reveal previously unappreciated functions of microRNA-142 and contribute to an emerging view of small RNAs as key players in erythropoiesis.
The analyses show that women's lifespan is more sensitive to the e4 allele than men's in all these populations.
The analyses suggest the existence of age- and gender-sensitive systemic mechanisms linking the e4 allele to lifespan which can non-additively interfere with cancer-related mechanisms.
The analyses were adjusted for age , gender , number of chronic conditions , cognitive impairment , lower extremity performance and education.
The analyses were carried out in the dentate gyrus area of the hippocampus using a Thioflavin-S stain and immunofluorescence assays.
The analyses were made in men and women separately.
The analyses were then stratified according to numerous indicators of health status.
The analysis also compares chronic disease and pain status.
The analysis also demonstrated how health as a moral discourse was actualised during the interviews.
The analysis also includes the consideration of gender imbalance of aging indicators.
The analysis by age revealed that the differences in this parameter between the two groups were significant in women aged @number@ years or older.
The analysis by Levine et al.
The analysis compared bootstrapped means and medians between and within these three methods.
The analysis confirmed that the progression of AD represents a complex multidimensional physiological process that is similar across different study cohorts.
The analysis confirmed the link between high AOPP levels and mortality risk , independent of other intervenient factors.
The analysis detailed within this article provides evidence that information and service provision must be tailored to individual caregiver experiences.
The analysis did not show any influence of IOD and long occlusion duration in the occurrence of MACE.
The analysis established two empirical categories : end of life care from the perception of family members and that of health professionals.
The analysis examined the effect of ADL hierarchy scale , CPS , joint motion and comorbidities on UI.
The analysis focused on the first @number@ consecutive commercial EPs collected between @number@ and @number@ and made from polyethylene terephthalate.
The analysis focuses on a single dengue outbreak typical of a region with a strong seasonally-varying mosquito population.
The analysis found themes that relate to relationships and change , as well as themes concerning core beliefs and existential questions.
The analysis found themes that relate to relationships and change , as well as themes concerning core beliefs and existential questions.
The analysis identified four latent sub-populations with class-specific longitudinal cognitive decline and mortality risk.
The analysis identifies crucial factors for consideration in developing clinical guidelines to deal with real-world patient observations.
The analysis included logistic regression , with odds ratios for the primary outcome and time-to-event analysis for mortality.
The analysis included the identification of brain regions involved and assessments of apathy and cognition.
The analysis included the results of @number@ published epidemiological studies , including people aged 65 + .
The analysis indicated that children and adults had similar levels of variability in the CMJ but different levels in the CMJA.
The analysis integrates two research avenues , aging with disability and disability trajectories.
The analysis is based on Kuopio Ischemic Heart Disease study , follow-up from @number@ to @number@
The analysis of antagonists revealed no significant effects on βarr recruitment.
The analysis of daily living language abilities improved selectively in AtDCS group.
The analysis of molecular weight used HPGPC chromatogram.
The analysis of primary mutant fibroblasts also showed reduced velocity and less contractibility.
The analysis of R2 ' related to R2 may provide valuable information about the size of iron deposits.
The analysis of regional LP changes of component P300 has found out the maximum distinctions between groups in frontal area of the left hemisphere.
The analysis of replicating mtDNA molecules provided in vivo evidence in support of the asymmetric mode of replication.
The analysis of single NPI items shows that delusions , agitation and apathy significantly improved in the experimental , but not in the control group.
The analysis of the collected data allows us to assume a reality of conditions at which zero rate of ageing is possible.
The analysis of the human balance allows for the understanding and identification of such strategies.
The analysis of the pathological mechanisms is hampered by the lack of detailed structural information on matrilin VWA domains.
The analysis of the studies on bone mechanical strength confirms the efficacy of physical exercise , which is an important element of comprehensive management.
The analysis of time-series examinations in a linear mixed effects model allowed the discrimination of population-based aging processes from individual determinants.
The analysis of twitch time and slope parameters demonstrated no significant correlations with lean mass.
The analysis relied on our recent strategy utilizing mass spectrometry-based enrichment of carbonylated peptides after DNPH derivatization.
The analysis revealed a significant alteration of long-term memory in women whereas there was no significant association in men.
The analysis revealed a significant small-to-medium effect of ABST ( d = @number@ ) and important moderators of the effect size.
The analysis revealed @number@ major themes.
The analysis reveals that all activities are positively related to cognitive functioning in elderly people.
The analysis showed a late stay of epidermal changes , which did not occur in the dermis.
The analysis used dietary AGE values from @number@ years before the AD prevalence data.
The analysis was a modified intent-to-treat comparison of treatment groups by multivariable linear regression adjusted for balancing factors as required by minimization.
The analysis was based on the sample of @number@ @number@ non-institutionalized adult population from Finland , Poland and Spain.
The analysis was carried out on @number@ fields of vision per one sample.
The analysis was conducted according to qualitative research methodology and the frame work method.
The analysis was conducted from January to @date@ .
The analysis was focused on the feedback-related negativity ( FRN ) and P3 , two ERP components that represent different stages of feedback processing.
The analysis was performed for all subjects and terciles of serum iron levels in relation to hs-CRP were calculated.
The analysis was performed using Poisson regression with robust variance estimation.
The analysis was repeated among carriers and noncarriers of the apolipoprotein E ( APOE ) ε4 allele.
The analysis was repeated on measles and parvovirus B19 antibody titers.
The analytical approach comprised latent growth mediation models.
The analytical focus is on the perspectives of the men with dementia and the strategies with which they respond to the condition.
The analytical sample consisted of @number@ adults aged ≥50years.
The analytical sample consisted of @number@ community dwelling adults aged > 50 years in spouse / partner relationships.
The analytical solution obtained by acid attack was used to acquire information on calcium and magnesium content with atomic-absorption spectroscopy.
The analytic approach was constructivist grounded theory.
The analytic approach was thematic and based on grounded theory.
The analytic equation for gender estimation ( y ) was y = @number@ x1 + @number@.042x2-12.979.
The analytic group included @number@ men with incident nonspine fractures ( @number@ hip ) and a random sample of @number@
The analytic sample included @number@ participants with cross-sectional measures of muscle parameters and @number@ participants with data on change in muscle parameters.
The analytic sample includes @number@ married women and @number@ married men ( aged 57-85 in the first wave ) who were interviewed in both waves.
The analytic strategy developed here could help adjudicate between degradation and deployment in other conceptual domains and other populations.
The analytic strategy included descriptive statistics , paired t tests , chi-square analyses , and repeated measures analyses of variance.
The analyzed cohort comprised @number@ females and @number@ males younger than @number@ years and @number@ females and @number@ males at least @number@ years.
The anaphase-promoting complex / cyclosome ( APC / C ) is an E3 ubiquitin ligase that targets proteins for proteosomal degradation by the 26S proteasome.
The anatomical distribution of imaging biomarkers is described in relation to estimated years from symptom onset.
The anatomical studies that the authors have performed regarding the neck , jowl , and subplatysmal elements have influenced the techniques that they now use.
The anatomical substrates for this type of tremor remain unknown at present.
The anatomic relationship changed in 10 / 120 ( @percent@ ) following insertion of the LMA.
The anatomy of lateral thoracic vein , angular vein and axillary vein was studied and compared with standard anatomical description.
The androgen receptor and its downstream effector pathways , central to prostate cancer initiation and progression , are subject to a multitude of epigenetic alterations.
The androgen receptor ( AR ) has a central role in prostate cancer progression , particularly treatment-resistance disease including castration-resistant prostate cancer.
The androgen receptor ( AR ) plays a critical role in the development and the progression of prostate cancer.
The anemia of inflammation ( AI ) is most often normocytic and normochromic and is usually mild.
The AngII + losartan group displayed longer telomere lengths , further reduced β-galactosidase staining and decreased P53 and P21 expression compared to the AngII group.
The angiotensin-converting enzyme ( ACE ) gene is a candidate genetic locus for coronary artery disease ( CAD ) .
The angle , angular velocity , and acceleration were analyzed based on the wave shape derived from the device worn around the second sacral.
The angles and triangular areas were summated into angulation indexes and used to quantify the degree of BA tortuosity.
The angular momentum changes show largest backward regulation for Step @number@ and forward regulation for Step @number@
The animal models seem indispensable for elucidating the biophysiological and etiopathological aspects of male and female sexual disorders.
The animal's ability to maintain homeostasis in response to different environments can influence its survival.
The animals were sacrificed at advanced stages of the disease ( @number@ month-old ) , and spleen , thymus , and plasma were obtained.
The animals were then assessed for spatial memory using a Morris water maze.
The ANIO approach yielded a quadratic cost function with linear terms.
The annual cases of bypass surgery for the PAD cases averaged @number@ and the cases for limb amputation ranged from @number@ to @number@ annually.
The annualized PBVC ranged from @percent@ to @percent@ per year.
The annual mean was @number@ cases ( SD = @number@ ) and the average rate 36 / 100 , 000.
The annual mortality rate exceeded @number@ deaths per @number@ individuals ; in other words , more than @number@ individuals die of cancer each year.
The annual mortality rate is @percent@ among the dialysis population.
The annual number of new 3-year survivors after severe sepsis rose @percent@ during @number@ to @number@
The annual percent change in age-standardized rates ( APC ) was estimated for specific causes of death in 2007-2015.
The annual prevalence of VTE increased with age : @number@ in patients ≥65 years versus @number@ in patients < 65 ( @number@ data ) .
The annual wound care products market is projected to reach $ 15.3 billion by @number@
The anomalous aggregation of proteins into pathological filaments is a common feature of a many human diseases , often related to aging.
The anorexia of aging was first recognized as a physiological syndrome @number@ years ago.
The answers were subjected to thematic analysis with an inductive approach.
The answer varies according to physicians , couples or society.
The antemortem diagnosis is further confounded by other diseases linked to hippocampal atrophy including frontotemporal lobar degeneration and cerebrovascular pathologies.
The anterior elbow , suprapatellar and retrocalcaneal bursae were evaluated for fluid.
The anterior inclination of the mandibular fossa was affected by aging and gender becoming steeper in Asians males than females.
The anterior inclination was significant steeper in males than in females on both the left and right sides.
The anterior maxillary bone has an average thickness of @number@ mm.
The anterior maxillary bone thickness was affected by age but this difference was not observed in canal dimensions.
The anterior sagittal cortex was @number@ mm larger than the posterior and the equatorial cortex was @number@ mm greater.
The anteroposterior ( AP ) diameter of the hiatus was less than @number@ mm in @percent@ of cases.
The antero-posterior sway component was demonstrated to be the best predictor of the MoCA overall score.
The anthropometric analysis and biochemical assays , as well as abdominal ultrasonic examination were performed.
The anthropometric features and age were combined to generate powerful predictors for OSA.
The anthropometric PE on average over-estimated LBM by @number@ kg in the combined cohort.
The anti-aging effect of C. fistula flower extract on human skin fibroblast was investigated.
The anti-aging effects of phloridzin on the yeast Saccharomyces cerevisiae were investigated by employing a replicative lifespan assay of the K6001 yeast strain.
The anti-aging hormone klotho and other glycosidases stimulate TRPV5-dependent Ca ( 2 + ) uptake.
The anti-aging protein Klotho is a type @number@ membrane protein produced predominantly in the distal convoluted tubule.
The antiaging protein of Klotho is a transmembrane protein mainly expressed in the kidney , parathyroid glands and choroid plexus of the brain.
The anti-atherogenic activity of HDLs can be explained by their functionality or quality.
The antibacterial mechanisms of N12D may be bacterial wall / membrane damage and disturbance of gluconeogenesis and the tricarboxylic acid cycle.
The anti-CCP assay results were compared with RF-IgM and CRP concentration analyzed in Catholic University.
The anti-cellulite effect was evaluated by the dosage of released glycerol and histological analysis of the hypodermis.
The anticholinergic drugs were identified using the Anticholinergic Drug Scale ( ADS ) .
The anticipatory component of postural control was not affected by age.
The anti-diabetic activity of ginger powder ( Chronic kidney disease is a major public health problem around the world.
The antidiabetic and insulin-sensitizing effect of berberine has also been confirmed in a few relatively small , short-term clinical trials.
The anti-fatigue ability was evaluated by using the time of exhausted swimming task and liver mitochondrial respiratory function was detected by Clark oxygen electrode.
The antifibrotic effects of STC1 include reducing oxidative stress , endoplasmic reticulum ( ER ) stress , and TGF-β1 production in AECs.
The antigen positivity was serotype-dependent and more frequent in nonvaccinated children.
The antigen was purified to homogeneity and characterised thoroughly by various biochemical and immunological methods.
The antiglycation activity of silibinin was dose-dependent.
The anti-inflammatory ability of CP11 was assessed in U937 cells , an immortalized human monocyte cell line.
The antioxidant activities in vitro measured through reducing power , the scavenging effects on hydroxyl radical and @number@ , ( DPPH ) radicals.
The antioxidant activity of Phytochemicals are botanical compounds used in dermatology applications as cosmeceuticals to improve skin health.
The antioxidant assays in vivo were conducted using mice model.
The antioxidant capacity was also determined after simulated in vitro gastrointestinal digestion of WSEs.
The antioxidant effectiveness of CoQ10-loaded usNLC compared to conventional nanocarriers was investigated in the human keratinocyte cell line HaCaT.
The antioxidant molecule N-acetyl- cysteine had no or minimal effects on Tat- or Nef-induced senescence.
The antioxidant tests of the DPPH , ABTS , and lipid peroxide models showed that these CS-SeNPs could scavenge free radicals at different levels.
The antioxidant vitamins C and E play an important role in the production of collagen , mesenchymal cell differentiation into osteoblasts , and bone mineralization.
The antiparkinsonian agents could be potential therapeutic agents to prevent or delay AD and LBD progression.
The antiplatelet action of C. digitatus was studied on platelet function : secretion , adhesion , aggregation , and sCD40L release.
The anti-proliferative function of miR-375 is possibly exerted , at least in part , by targeting 14-3-3zeta and SP1 genes.
The anti-senescence mechanisms of CGRP on EPCs were investigated either by applying CGRP antagonist or by silence of klotho , an anti-aging protein.
The anti-skin aging effects of ( EGCG ) have been studied extensively in vitro and in vivo models.
The anti-tumor necrosis factors ( TNFs ) appear to be slightly less effective in the elderly.
The ANT scores did not differ among the groups.
The ANU-ADRI may be used for population-level risk assessment and screening.
The AoA rating estimates appear to be relatively consistent across participants.
The aorta expanded homogeneously and stretched heterogeneously with age because of posterior arch elongation.
The aorta possesses a micro-architecture that imparts and supports a high degree of compliance and mechanical strength.
The aorta stiffens with aging , a process that is accelerated by arterial hypertension.
The aortic circumference , especially in the descending portion , serves as an excellent age-related marker.
The aortic morphology was age-dependent.
The aortic pressure waveform was recorded using a pressure sensor mounted catheter , and augmentation index and subendocardial viability ratio were calculated.
The aortic root is wedged within the cardiac base.
The AP-2α strongly repressed the reporter expression in the CC genotype and showed less repression of the TT genotype driving expression in vitro assay.
The APC and yeast-mold counts were within expected ranges.
The AP-direction sway is significant larger than the ML-direction sway , particularly in the test conditions with sway-surface.
The aperture moved in a rectangular pattern over a fixed time period.
The AP group showed motor control strategies governed by prolonged TRT in both conditions.
The APH transgenic model we developed will enable in vivo testing of the roles of crystallin fragments in protein aggregation.
The Apo D promoter shows @number@ estrogen response elements and it has been shown that its expression is influenced by estrogens in breast cyst fluid.
The APOE-4 allele modulates hemispheric asymmetry in entorhinal cortical thickness.
The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its influence on exceptional longevity ( EL ) is uncertain.
The APOE genotype significantly modified the association between both biomarkers.
The APOE ε4 allele , cognitive function , and incident stroke were associated with mortality.
The APOE ε4 allele increases the risk for sporadic Alzheimer's disease and modifies brain activation patterns of numerous cognitive domains.
The ApoE ε4 allele is associated with an increased mortality risk , and its effect has been suggested to decrease with age.
The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.
The APOE-ε4 allele may interact with testosterone and moderate the hormone's association with cognition.
The Apolipoprotein E ( APOE ) ϵ4 allele is the greatest known genetic risk factor.
The apolipoprotein E ( APOE ) e4 allele is strongly associated with increased risk of cognitive impairments in older adulthood.
The apolipoprotein E ( APOE ) gene has been consistently shown to modulate the risk of Alzheimer's disease ( AD ) .
The apolipoprotein E ( APOE ) gene is associated with structural and functional brain changes.
The apolipoprotein E ( APOE ) gene is the strongest genetic risk factor for late-onset Alzheimer disease.
The apolipoprotein E ( APOE ) ε4 allele and hypertension are two of the most prevalent risk factors for cognitive decline in later life.
The apolipoprotein E epsilon @number@ allele ( ApoE-ε4 ) is the strongest known genetic risk factor for late onset Alzheimer's disease.
The apolipoprotein E gene ( APOE ) is a susceptibility gene for AD with the e4 allele being associated with a greater risk of AD.
The apolipoprotein E ε4 allele is a prevalent and potent risk factor for AD that has facilitated research into its preclinical phase.
The apoptosis mechanism of action was assessed by the level of caspase-3 activity and expression of apoptosis related genes , Bcl-2 , Cdk1 and p53.
The apoptosis-related protein , caspase-3 , Bax and blc-2 were abnormal expression in the anterior lens capsules of age-related cataract tissue.
The apoptosis-related proteins BAX and BCL2 as well as MYCN mRNA express were determined by RT-PCR analysis.
The apoptosis was suppressed by caspase @number@ and @number@ inhibitors.
The apoptosis was triggered through extrinsic pathway by up-regulating DR5 modulating as well as through intrinsic pathway by modulating IAP family members.
The apoptotic cells were detected with Annexin V staining analysis by flow cytometry.
The apoptotic-related protein , caspase-3 , Bax and blc-2 were analyzed by western blot.
The apparent age was compared with the patient's actual age , and the reduction in apparent age was calculated.
The apparently protective effect of heavier drinking was partly due to less healthy former heavy drinkers who moved to lower drinking categories.
The apparent negative effect of CEE / MPA on verbal memory does not appear to be age-dependent.
The apparent stiffness coefficient values were higher while the damping coefficients were lower in older adults leading to lower damping ratio.
The appearance and shape of the caudate tail were classified into nodular , linear , or imperceptible.
The appearance of facial expression wrinkles is the result of chronic contraction of mimic muscles.
The appearance of human scalp hair is often tied to perceptions of youth and virility , especially in men.
The appearance of new-onset criminal behavior in an adult should elicit a search for frontal and anterior temporal brain disease and for dementing disorders.
The appearance of new RFs and the growth of previously formed RFs occur over time.
The appearance of senescence was associated with polyploidy in which β-galactosidase is exclusively expressed in polyploid cells.
The appearance of these scars is often worsened by the normal effects of aging.
The appearance of the treated condition was evaluated in a retrospective study by two blinded investigators based on follow-up photographs and by patient self-assessment.
The appendicular LMI was more strongly associated with total body BMC and TBLH BMC than was total body LMI.
The applicability of knowledge in this field lies in possible interventions intended to counteract these age-related losses.
The applicability of the Ach index was examined in an elderly population of healthy controls and patients suffering from various causes of cognitive decline.
The application of a Bayesian LME framework allows for additional information to be extracted from longitudinal studies.
The application of antioxidants from various sources in skin care products and food supplements is therefore widespread , with increasingly effective formulations being introduced.
The application of antisenescent approaches to the prevention of auditory aging has produced inconsistent results.
The application of a silane coupling agent alone showed very low values in the TBS test.
The application of CH showed significantly less microleakage than that of the control group at the gingival margins of Nexus @number@ after @number@ months.
The application of CRF-specific HRpeak prediction equations should be used to improve interpretation of HRpeak from exercise tests.
The application of current guidelines for the assessment of chronic inflammation failed to detect a single case of \ "high risk \ " CRP.
The application of metabolomics to aging research is still relatively new , but has already added significant insight into the aging process.
The application of self-generation procedures has been found to improve memory in healthy elderly and in individuals with impaired cognition.
The application of SNA identifies critical aspects derived from over-connected portions of the network.
The application of STOPP / START may be further augmented with relevant criteria from PIEA and Beers.
The application of such a network dynamics concerns the sequence overweight / obesity / type II diabetes and neurodegenerative diseases.
The application of sunscreen may in some instances need to be adjusted to take into account the increased roughness of highly sun-exposed anatomical sites.
The application of these findings may provide a novel clinical strategy for the early detection of individuals at increased AD risk.
The application of TIgGER to Rep-Seq data from seven subjects identified @number@ novel V segment alleles , including at least one in every subject examined.
The application rate is higher and interference with cognitive as well as linguistic deficits is lower.
The applications of IR therapy have moved on rapidly in recent years.
The applications were carried out by a dermatologist , once a mont h every @number@ days , during @number@ months.
The approach consists in testing whether the frequency of an allele varies across ages , accounting for variation in ancestry.
The approaches mentioned for decreasing n-6 / n-3 ratios have both advantages and disadvantages.
The approaches rely on propensity score-based adjustments , and we demonstrate that estimation of the propensity score must be adjusted to acknowledge the length-biased sampling.
The approach has potential uses for early detection of AD and differentiation between stable and progressing MCI.
The approach improves feasibility of examining large publicly available datasets.
The approach incorporated adult learning strategies based on Ajzen's Theory of Planned Behavior.
The approach is probed on two published focused attention studies.
The approach is simple , quick , and well tolerated by the patient and may result in less bruising than deeper techniques.
The approach to implement the policy of active and healthy longevity as a valuable asset of the modern society is underlined.
The approach to pain assessment and management is often different and more complex for older patients than for younger ones.
The approach to the removal of excess fluid should be similar : the avoidance of large ultrafiltrations and , above all , rapid ultrafiltration rates.
The appropriate cut-off values of all anthropometric indices for cardiometabolic abnormalities were obtained.
The appropriate expression of complex sets of genes is needed for oocyte maturation and early embryo development.
The app was given to patients by research assistants , not by physicians.
The Arabic version of the Mini-Mental State Examination ( MMSE-A ) was used to evaluate the cognitive functions of all participants.
The arbitrary age limits for RES need reconsideration in the face of an ever increasing elderly population.
The architectural features , reminiscent of the human thymus , are intrinsic to the nonhematopoietic compartment and are neither necessary nor sufficient for thymic involution.
The arc of scientific progress is now requiring a change in how we diagnose Alzheimer's disease.
The area and length of skin furrows and the number of skin ridges decreased with age.
The area of the parotid duct penetrating the buccinator muscle was fully formed in 5-month-old fetuses.
The areas in which hospitalists expressed the least confidence were in caring for patients with dementia , self-care issues , and care planning.
The areas with decreased FA continuously enlarge with aging.
The area under the curve demonstrated poor sensitivity and specificity for p-tau , but moderate sensitivity and specificity for t-tau and p-tau / t-tau ratio.
The area under the curve for discriminating between healthy controls and aMCI was @number@ and between healthy controls and mild AD was @number@
The area under the curve for procalcitonin in predicting in-patient mortality was @number@ ( @percent@ CI @number@.70-0.98 , P = @number@ ) .
The area under the curve of the ROC curve of the early responders was @number@
The area under the curve of the ROC curve of the early responders was @number@
The area under the receiver operating characteristic curve ( AUC ) was used to compare test discriminatory ability.
The area under the receiver operating characteristic curve for the Stanford Age and Diffusion-Weighted Imaging score was 0·82 in the derivation dataset.
The area under the receiver operating characteristic curve ( ROC AUC ) was calculated as a measure of diagnostic accuracy.
The area under the receiver operating characteristic curve was used to analyse the predictive capacity of a variable.
The area under the receiver-operating curve for CRP was @number@ using CCS C100 as a binary outcome.
The area under the receiver operating curve was @number@
The area under the ROC curve ( AUC ) for the PHQ-2 was @number@
The area under the ROC curve for moderate and high RD risk ratings were @percent@ and @percent@ , respectively.
The area under the ROC curve for volume , shape , and the combination of both were , respectively , @number@ @number@ and @number@
The area under the ROC curve in each one-year age group was defined as AUCage.
The area with wrinkles was calculated by planimetry point counting , in accordance with Mandarin-de-Lacerda.
The AREDS2 follow-up study , designed to improve upon the earlier formulation , tested the addition of lutein , zeaxanthin , and ω-3 fatty acids.
The arithmetical mean of the IMT value was calculated.
The arithmetic mean height as a roughness parameter and the void volume of the surface profile were calculated.
The armband was placed around the left upper triceps for up to @number@ days.
The Armitage-Doll multi-stage model of carcinogenesis tremendously refocused cancer science by postulating that carcinogenesis is driven by a sequence of genetic changes in cells.
The arrested spermatocytes in Ing2 ( - / - ) testes were characterized by lack of specific HDAC1 accumulation and deregulated chromatin acetylation.
The ARRs were higher under RCP @number@
The arterial baroreflex is fundamental for evoking and maintaining appropriate cardiovascular adjustments to exercise.
The arterial burden of MetS increased as the number of altered MetS components increased.
The arterial endothelial dysfunction in aging and diabetes remains a clinical problem.
The arterial stiffness and limb blood flow responses to resistance training in young and older women have not been well-studied.
The arteriole was measured at its widest diameter , the arteriolar wall at its thickest portion , and the luminal diameter between its widest points.
The artery was assessed for an aberrant path.
The arthritis only group was three times more likely to report upper-lower extremity functional limitations and ADL disability.
The article addresses the main issues related to the diagnosis and treatment of asthma in the geriatric age.
The article also considers the prospects for using of music in the treatment and prevention of age-associated diseases.
The article also reports on a small survey of students who were exposed to such a teaching technique in an undergraduate aging course.
The article analyses the role of handbags in the everyday lives of women with dementia.
The article concludes by discussing the key elements and resources needed to develop age-friendly cities.
The article concludes with a conceptual model of glucocorticoid actions in the brain that may lead to novel therapeutic opportunities.
The article concludes with concern about the support of observational studies for future randomized clinical trials.
The article concludes with policy and practice recommendations to reduce these disparities in access to mental health services for diverse populations of older adults.
The article concludes with policy and research implications of these findings.
The article concludes with practice implications for social workers who may encounter older individuals with IDs and SIB.
The article considers two possible explanations : normative change and life stage resources.
The article contains the results of studies of clinical and morphological features of chronic gastritis of viral and bacterail etiology in age aspects.
The article covers the use of sildenafil in patients with diseases of the cardiovascular system , diabetes , hypogonadism.
The article demonstrates the results of the researches executed by authors , and other leaders of this direction in a medical science.
The article describes the current diagnosis and treatment modalities of subclinical thyroid dysfunction in the older age group.
The article describes the etiologies behind the dysmorphologies in this area and presents a problem-oriented algorithm for treating them.
The article discusses guidelines for the choice of intervention.
The article discusses some ethical problems within this context.
The article discusses the role of a number of social factors to identify trends.
The article discusses the self-perception of life satisfaction and health of senior citizens.
The article discusses the usefulness of the known biomarkers of Alzheimer's disease in early diagnosis.
The article explores and evaluates the quality of life , safety , and security of elderly people in Tehran City in Iran.
The article explores the assessment and the management of the most common and debilitating symptoms in older cancer patients.
The article first provides a general introduction to DF world , and an overview of the different materials is available for fillers.
The article gives a broad overview of the factors of cancer , presents biopsychosocial model of development of oncological diseases.
The article is devoted community principles and stages of the psychoprevental and correctional approach for teenagers with beer.
The article may help guide others in their molecular-based endeavors to identify paths leading to discovering new treatments and new pathogenic aspects.
The article posits a conceptual model of how this phenomenon of \ "aging better together intentionally \ " occurs and the resulting benefits.
The article presents clinical description of nucleopathies in children , their causative mutations and pathophysiology.
The article presents research data on the effectiveness of the drug melatonin in the climacteric syndrome.
The article presents results of studies.
The article presents some aspects of the health status of the veterans of the Samara region.
The article presents the results of a clinical study on the features of age-related pathology of the salivary glands.
The article presents the results of research on the structure , chemical and mineral composition of hard tooth tissues of persons of different age groups.
The article presents the results of studies of the behavioral response in @number@ elderly women.
The article presents the results of the study of self-assessment of quality of life of older Kazakhstan citizens.
The article provides an overview of trends in the incidence and mortality of prostate cancer in the Czech Republic and Europe.
The article provides evidence of ways that consumers are trying to \ "time bend \ " and change today's perceived reality of aging.
The article represents evidence about structures , properties and functions of adhesion molecule JAM-A / 1 belonging to JAM subfamily.
The articles also reveal important areas of future research and policy innovation that are needed related to place and aging.
The articles in this Review series outline current developments in vision research and highlight its continued importance in ophthalmology and medicine.
The articles in this supplement are based on a conference held in @date@ sponsored by a grant from the Robert Wood Johnson Foundation.
The articles portrayed sexual interests and functioning as declining in later life ( @percent@ ) more often than sustaining ( @percent@ ) .
The articles reviewed in this study indicated a greater focus on aging issues and addressing issues during this life cycle stage.
The article suggests qualitative methodologies as an interpersonal means of exploring DA within the contexts of psychotherapy and counselling.
The articles were preselected based on searches for comprehensive reviews covering diseases of the VMI.
The artificial iris is the structure responsible for the dissimulation and aesthetics of ocular prosthesis.
The artificial saliva aging and thermocycling did not interfere with dentin bond strength.
The aryl hydrocarbon receptor ( AhR ) is a nuclear receptor that regulates xenobiotic metabolism and detoxification.
The ASAP1-depleted DCs showed impaired matrix degradation and migration.
The ASAP1 protein is involved in actin and membrane remodeling and has been associated with podosomes.
The ascending aorta was the only curvilinear length unaffected by age , whereas the supra-aortic trunks parted from each other.
The ascertained CVD risk factors were self-reported and / or directly measured hypertension , diabetes mellitus , obesity , waist circumference measurement , and smoking.
The ascetic type and splenomegaly type of advanced schistosomiasis patients were the most.
The ASEAN Economic Community's ( AEC ) goal of regional economic integration and a single market by @number@ presents both opportunities and challenges for UHC.
The Asia-Pacific has the largest diabetes burden in the world.
The Asia-Pacific is first in rank in terms of the number of urban dwellers.
The as-prepared composite did not induce any cytotoxic response in vitro or in vivo.
The as-prepared composite was also found to exhibit acceptable electrochemical performance , which was retained upon @number@ weeks storage in argon atmosphere.
The ASRs of CRC incidence stabilized during the period of 2000-2011 for both males and females.
The assay displayed saturable kinetics and detected Synj1's substrate preference for PI ( @number@ ) P2 over PI ( @number@ ) P3.
The assay is designed to detect aberrant promoter methylation of RARβ2 gene in ejaculate samples.
The assay was also validated in an independent set of samples using Southern blot ( r = @number@ ) .
The assembly and disassembly of nucleosomes is dependent on the function of histone modifiers , chromatin remodelers and histone chaperones.
The assessed neurocognitive components were attention , episodic and working memory , communicative and executive functions.
The assessed nutritional indicators were investigated by univariate and multivariate logistic regression analysis to verify if they can predict MNA classification.
The assessment and the monitoring of chronic wounds are mainly based on visual inspection by medical professionals.
The assessment consisted of 3D gait analysis : all pathological participants performed gait analysis in a longitudinal examination , from childhood to adulthood.
The assessment included a medical history , anthropometric measures and dietary intake.
The assessment included structured interview , physical examination , geriatric functional assessment , resting electrocardiography , and blood and urine sampling.
The assessment involved a battery of standard neuropsychological tasks and STM binding tasks.
The assessment of age at death for identification purposes is a frequent and tough challenge for forensic pathologists and anthropologists.
The assessment of apo ( a ) isoform size in this cohort does not add significant information about CHD risk.
The assessment of balance disorders , particularly in geriatric patients , is based on validated scales composed of several items.
The assessment of cell activity and protein expression in a larger number of patients could be next step to support and supplement the present data.
The assessment of coexpressed gene list now uses more reasonable P-values derived from platform-specific null distribution.
The assessment of features of built environment is crucial when thinking about ageing and enhanced participation.
The assessment of general conditions in elderly patients , as demonstrated by the literature , is a fundamental moment in the management of colorectal cancer.
The assessment of health-related quality of life was also performed.
The assessment of physiologic age is currently based on a comprehensive geriatric assessment ( CGA ) .
The assessment of suspected dementia often involves the analysis of change scores from neuropsychological tests administered on two occasions.
The assessments were completed by independent housing sites in COLLAGE , a non-profit , national senior housing consortium.
The assessment times will be @number@ @number@ @number@ and @number@ months.
The assistance provided by an exercising specialist decreased gradually during the intervention in an autonomy-oriented approach based on the self-determination theory.
The assistive robots designed for people with dementia mostly focus on companionship.
The associated factors were corneal curvature , age and sex for the different astigmatisms ( p < @number@ ) .
The associated financial implications were calculated for the United States.
The associated health care cost is great.
The associated increased levels of aromatase in the breast provide a plausible mechanistic link between WAT inflammation and estrogen-dependent breast cancers.
The associated lumbar extensor muscle activity was derived from measurements at standing , half , and maximum flexion positions.
The associated PR for IVD pathology occurring concurrently with Modic changes ranged from @number@ to @number@ ( p < @number@ ) .
The associated quasi-static boundary value problem was solved semi-analytically over a cardiac cycle while accounting for surrounding perivascular tissue.
The associated RNA was able to effectively activate the deacetylase and defatty-acylase activities of SIRT7.
The association among GSTP1 Val105 carriers was comparable to that of @number@ years of age in baseline MMSE scores.
The association among sarcopenia with adiposity and metabolic markers has rarely been studied in the elderly population , with controversial results.
The association appears to be independent of cerebrovascular disease and atherosclerosis.
The association became non-significant after adjustment for health status.
The association between 25 ( OH ) D status and ADMA concentration was analyzed by multiple linear regression models.
The association between AC drug and HRQoL was determined by a mixed model analysis using four annual time points.
The association between ACL and cognitive function was examined for each diagnostic group ( HC , MCI , AD ) .
The association between adherence to dietary patterns and plasma lipid levels was assessed by linear and logistic regression.
The association between ADL limitations and health conditions was assessed through logistic regression.
The association between ADL task disability and the daily percentage of sedentary time was evaluated by multiple logistic regression.
The association between adverse health and loneliness among aging people is known , but most of the studies are cross-sectional.
The association between age and NKA content was investigated within the OA and CON groups and in pooled data.
The association between ageing and cancer seems to be more than apparent.
The association between AII and cerebral microbleeds may indicate cerebral vasculopathy , independent of traditional vascular risk factors.
The association between andropause and psychological symptoms such as depression are not very clear yet.
The association between APOE and late-onset AD has also been reported.
The association between baseline hemoglobin and depression was assessed with adjusted Cox regression analyses.
The association between baseline serum vitamin E and cognitive impairment was analyzed with multiple logistic regression after adjusting for several confounders.
The association between blood pressure and dementia seems to be complex and far from being unidirectional.
The association between BP and handgrip strength was analyzed by linear regression analysis.
The association between buccal TL and testosterone was tested using multivariate generalized estimating equations to account for clustering of children within families.
The association between CC and current ADL score was stronger than the association between current ADL score and either BMI or MAC.
The association between childhood cognitive ability and older-age diabetes was partly accounted for by body mass index and cholesterol level in older-age.
The association between cognitive cerebellar GMV and gait speed was no longer significant after adjusting for DSST score in the linear regression models.
The association between cognitive impairment and mortality contributes to assessing cognitive impairment-related risk constellation in old age in the absence of manifest dementia.
The association between COL5A1 BstUI RFLP and sit and reach ( SR ) ROM in an apparently healthy and physically active cohort was investigated.
The association between concurrent testosterone levels and high depressive symptoms ( CES-D ≥16 ) differed by race ( p = 0.008 ) .
The association between COPD and risk for death was moderately attenuated by disability status.
The association between CRP and CCS persisted even after adjustment for age , sex , cardiovascular risk factors and statin therapy.
The association between delirium and disability in critically ill patients has not been described.
The association between depression and positive / negative exchanges was weaker among the above 70s compared with those aged @number@ to @number@
The association between depression and the risk of CDR decline and dementia was observed in non-demented Chinese subjects.
The association between disability and MetS at baseline and after follow-up was assessed by logistic regression.
The association between DNA damage to the lens epithelium and the development of lens opacities has been reported in many studies.
The association between DNA methylation changes and gene expression levels was also investigated in the same individuals.
The association between drugs and falls has been widely studied in the past @number@ decades , with increasingly robust evidence of a causal link.
The association between education and good health is well established , but whether the strength of the association depends on other social statuses is not.
The association between education and inpatient or outpatient care use did not change over time.
The association between eGFRcr and outcomes tended towards a U-shape.
The association between erectile dysfunction and cardiovascular diseases is not proven in primary care.
The association between erythropoiesis and adiponectin in elderly men is unclear.
The association between felt age and well-being is moderated by developmental assessments.
The association between functioning of the hypothalamic pituitary adrenal ( HPA ) axis and physical performance at older ages remains poorly understood.
The association between GAD and longer term BPV was consistent when analyzing morning and evening HBPM measures of BPV.
The association between gastric acid secretion and chronological period was assessed with a multivariate linear regression analysis.
The association between genotype , PD risk and phenotype was tested using multivariate regression models.
The association between greater baseline CIMT and the progression of cognitive impairment was maintained after adjustment for conventional baseline risk factors of cognitive impairment.
The association between HAS and mortality was assessed with Cox proportional hazards models.
The association between health literacy and screening was estimated using multivariable-adjusted logistic regression.
The association between hsTnT and HCY was not present in the younger subgroup ( < 65 years old ) .
The association between hypovitaminosis D and diabetes in older adults is equivocal , however.
The association between IGF-1 and delirium was evaluated with logistic regression.
The association between increased stride time variability and SMI has not been reported.
The association between intensity during sedentary time and metabolic syndrome was borderline significant.
The association between IOP and BMI , plasma lipid profiles was examined using cross-sectional analysis.
The association between laxative use and self-reported constipation was poor and laxative use was associated with self-reported constipation in less than a third of cases.
The association between lens power and AL differed between the nonmyopes and myopes.
The association between life space and mortality was examined using proportional hazards models adjusted for age , sex , race , and education.
The association between life-space mobility and depressive symptoms should be studied further utilizing longitudinal study designs to examine temporality and potential causality.
The association between long-term cancer survivorship and cognition score was significant ( p < @number@ b = @number@ ) .
The association between low bio-T and dementia may be more relevant to men @number@ years or older and men with a high level of education.
The association between lower baseline serum TSH levels and the development of MCI or dementia was maintained after adjustment for conventional baseline risk factors.
The association between lower general cognitive functioning and perceiving sexuality as unimportant seemed stronger in women compared with men.
The association between low-grade inflammation and endothelial dysfunction , and cognitive functioning was evaluated with linear regression analysis.
The association between low to moderate arsenic exposure and kidney disease has not been fully clarified.
The association between lumbar spine BMD and uric acid remained significantly positive after excluding women older than @number@ years.
The association between menstrual and childbearing factors and the risk of lung cancer among women is still debated.
The association between metabolic syndrome and DNA methylation is of great research interest.
The association between moderate activity and incident MCI was not significant ( HR = @number@ @percent@ CI = @number@.67-1.09 ) .
The association between moderate PA and NCI was driven by executive function ( p = @number@ ) .
The association between mppBMI and offspring ΔBMI was slightly attenuated ( @percent@ ) with the addition of genetic scores.
The association between multimorbidity and subjective memory complaints was positively influenced by age.
The association between muscle quality ratio and nerve conduction velocity was maintained after adjustment for anthropometric measurements ( P < @number@ ) .
The association between muscular strength and all-cause mortality tended to be stronger in women.
The association between mutational status and treatment outcome was evaluated.
The association between negative marital experiences and cognitive limitations is similar for men and women.
The association between @number@ different frailty characteristics and the receipt of a PHV was assessed through logistic regression.
The association between OSA and TL was determined using unadjusted and adjusted linear models.
The association between paraseptal emphysema and interstitial lung abnormalities was investigated.
The association between peripheral fractures and bone microarchitecture was weaker and nonsignificant after adjustment for aBMD.
The association between PFT and SPPB abnormality was examined using multiple logistic regression analysis.
The association between PiB / FDG results and changes in management was evaluated using χ ( @number@ ) and multivariate logistic regression.
The association between PIMs used and independent variables were analyzed by logistic regression.
The association between plasma Aβ concentrations and the risk of dementia was assessed using Cox proportional hazard models.
The association between plasma total tau levels and cognition is independent of elevated brain Aβ.
The association between polymorphisms and glucose levels did not differ between controls and offspring ( Pinteraction = 0.523 ) .
The association between polypharmacy ( > 4 medications ) or fall risk-increasing medications and subsequent falls or injurious falls was assessed using modified Poisson regression.
The association between potential risk factors and SWB was assessed by logistic regressions analyses.
The association between PrCCI and mortality shows that it is useful as comorbidity index.
The association between pre-diagnostic and time-dependent post-diagnostic beta-blocker use and overall survival was estimated using Cox proportional hazard regression models.
The association between retirement , ageing and their interaction on sedentary and ambulatory outcomes were examined.
The association between retirement and blood pressure was stronger for men and for urban dwellers.
The association between RS functional connectivity and executive functions was assessed in @number@ patients with neuropsychological assessment.
The association between serum IGF-1 and fracture risk is partly mediated via BMD.
The association between serum thyroid hormone concentration and cognitive function was investigated.
The association between speed of information processing and cognition has been extensively validated in normal aging and other neurocognitive disorders.
The association between ST and candidate predictor variables was examined with regression analysis.
The association between SVD , its microstructural integrity , and incident dementia and parkinsonism has never been investigated.
The association between SWB , operationalized as affect and life satisfaction , and all-cause mortality risk was examined using between-individual and within-pair survival analyses.
The association between symptoms of depression and self-rated mental health was weaker among minority groups than that among non-Hispanic Whites.
The association between targeted therapy utilities and their perceived financial burden was evaluated using a multivariable logistic regression.
The association between telomere length and education remained significant after adjusting for current socioeconomic circumstances.
The association between the cut-off score for BBS-9 and fall risk was tested using the Chi-square test.
The association between the degree of Prx @number@ expression and several clinicopathologic parameters was then evaluated by statistical analyses.
The association between the EQ-5D index and SPPB abnormality was examined using multinomial logistic regression analysis.
The association between the fracture and folate levels or their related gene polymorphisms is not completely clear.
The association between the metabolic syndrome ( MetS ) and adverse outcomes in older adults may be explained by other health conditions.
The association between the polymorphisms and RA was analyzed using the chi-square test and de Finetti program.
The association between these anthropometric measurements and all-cause and cardiovascular mortality were independently estimated by Cox proportional hazards model.
The association between these biomarkers and lung cancer risk was evaluated using conditional logistic regression models.
The association between these disorders , mood and functioning , and the direction of causality , warrants further investigation.
The association between these four categories and MS maintenance was evaluated using General Linear Modeling ( GLM ) .
The association between these SNPs and bone mineral density ( BMD ) measured using dual-energy X-ray absorptiometry ( DXA ) was also tested.
The association between the variables for each condition was tested using Spearman's correlation ; Wilcoxon signed ranks test was used to test North-South Europe differences.
The association between tibia lead and MMSE score appeared progressively steeper in participants with increasingly more GSTP1 Val105 alleles.
The association between time spent in sedentary behavior and mortality varied according to time spent at higher activity level.
The association between vascular pathology and antemortem rates of cognitive decline adjusted for level of AD pathology was assessed using linear mixed-effects models.
The association between VASH1 expression in the tumour and clinical outcomes was analyzed statistically.
The association between VE and type @number@ diabetes has , however , not been investigated prospectively.
The association between visual attention and emotional reactivity differed by age group and positive reappraisal.
The association between vitamin D deficiency and the metabolic syndrome was mainly determined by the components low HDL and ( high ) waist circumference.
The association between white matter lesions ( WMLs ) and other cardiovascular risk factors ( CVRF ) remains controversial.
The association cortex of the superior temporal gyrus ( STG ) is implicated in complex social and linguistic functions.
The association could not be explained by known demographic factors , health behaviors , or biological factors.
The association did not differ by sex , study design , or after restricting to glioblastoma , the most common histological subtype.
The association did not vary by surgical indication for oophorectomy.
The association for advanced fibrosis / cirrhosis persists even among participants without hepatitis C and / or HIV infection.
The association for short sleep was smaller ( and not statistically significant ) ( HR = @number@ [ @percent@ CI @number@ @number@ ] ) .
The association is largely mediated by markers of both neurodegeneration and cerebrovascular disease.
The association is modulated by concurrent cholesterol concentration.
The association is particularly important in sub-Saharan Africa , given the poverty in the region.
The association is stronger in men than in women and persists at very old ages.
The association LDD-OP-fractures in females was lower and not significant ( adjusted-HR : @number@ 95%CI : @number@.82-1.41 ) .
The association of advanced fibrosis / cirrhosis and incident CHF persisted regardless of HIV / HCV status.
The association of age at first birth with BMI was greatest for women age @number@ and younger.
The association of age with the height and the proportion of temporal length to the entire horizontal diameter were evaluated in each group.
The association of ASM modes with incident hip fracture was analyzed by logistic regression.
The association of certain exposures with increased hazard of injurious falls begins earlier than previously studied.
The association of CRC risk and beta blocker use and subclasses of beta blockers was estimated by multiple logistic regression.
The association of diabetes with RFFT score was not modified by APOE ε4 carriership.
The association of DISH with Cobb angle is stronger within the African American population.
The association of e2 genotype with slower visual search performance complicates the premised protective effects of this allele in cognitive ageing.
The association of each of these processes with aging may account for the greater severity of malaria observed in older adults in low-endemic regions.
The association of each social network measure with BMI was investigated by multiple linear regression analysis.
The association of estradiol with visceral and subcutaneous fat tertiles varied by menopausal status ( p < @number@ ) .
The association of fasting glucose and nocturnal hypoglycemia based on CGM data was analyzed , comparing with bedtime glucose.
The association of GORD and the type of Hp gastritis remains to be confirmed.
The association of HAART and transition to menopause on SILs was assessed using survival analysis.
The association of increased visceral adipose tissue with both drug-related and chronic inflammation-related factors is now better understood.
The association of individual dietary and lifestyle patterns with HT was assessed by fitting into binary logistic regression models.
The association of lens power and AL was analyzed using multiple regression.
The association of lifestyle and facial ageing has been less well studied.
The association of myopia with incidence of age-related cataract could not be confirmed in meta-analysis of @number@ study findings.
The association of neurodegenerative and inflammatory processes appears to play an important role in the pathogenesis and the clinical course of cognitive impairment after delirium.
The association of number of drugs with fall risk indices was stepwise.
The association of @number@ predictor variables with the successful aging score in the schizophrenia group was examined.
The association of obesity with poor outcomes is attenuated across more advanced CKD stages and eventually reverses in the form of obesity paradox.
The association of objectively measured physical activity with leukocyte telomere length ( LTL ) is currently unknown.
The association of occupational PA during the longest held occupation with disability in old age was determined using logistic regression.
The association of ocular HOAs with corneal parameters indicates that ocular HOAs are mainly generated by the cornea.
The association of PCF with grip strength disappeared when MIP alone or \ "MIP and MEP \ " were included in the regression analysis.
The association of pericardial fat with incident CVD events was independent of these biomarkers only among Hispanic Americans.
The association of PIMs with HRQoL was analyzed using Mann-Whitney U test.
The association of PIM with overall mortality was not statistically significant ( risk ratio ; @percent@ confidence interval , @number@ @number@.95-1.35 ) .
The association of PON1 rs662 polymorphism and serum lipid levels was different among the three groups.
The association of severe aortic stenosis ( AS ) with AD in different aortic regions has not been evaluated.
The association of sleep disorders and stroke is exciting.
The association of sociodemographic , lifestyle and health-related variables with care need and care arrangements at baseline and four years later were analyzed.
The association of SVD with atrophy did not follow a consistent pattern.
The association of the CPT1C mutation with changes in lipid droplet biogenesis supports a role for altered lipid-mediated signal transduction in HSP pathogenesis.
The association of the intraocular pressure and the refraction was also highly significant ( p > @number@ ) for the three groups.
The association of the latter variables with SF-36 Health Survey physical component ( PCS-36 ) were evaluated in the whole sample.
The association of these discordant SBP targets with cognition and differences by race have not been systematically evaluated in the same population.
The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians.
The association of these three gait assessment modes with incident falls was examined using Cox proportional hazards models.
The association of total protein with frailty may be observed regardless of the source of protein and the amino acid composing the protein.
The association of TSH levels in the euthyroid and subclinical hypothyroid range with incident AF was examined by using Cox proportional hazards models.
The association peak lies within and very close to the maximum linkage peaks of @number@ prior positive linkage studies defining the PARK10 locus.
The association persisted after additional adjustment of bone mineral density and inflammatory markers ( P for trend = 0.017 ) .
The association persisted for self-reported hypertension even after adjustments for BMI and history of diabetes ( OR = @number@ @percent@ CI @number@.77-4.59 ) .
The association persisted in analyses restricted to individuals not taking sleep medication ( ORQ4 vs Q1 = @number@ @number@ % CI = @number@.54-0.95 ) .
The association persisted when the potential confounding effect of having a partner was taken into account.
The association remained after adjustment for cardiovascular disease risk factors.
The association remained robust among those without preexisting diseases and those who reported sleeping well.
The association remained significant after adjusting for demographics , APOE ε4 , baseline 3MS score , comorbidities , and renal function.
The associations and determinants of hypertensive organ damage , the principles of treatment , and the possibility of rejuvenation of the cardiovascular system are discussed.
The associations are consistent for the N-SLI group but rather more mixed for the SLI group.
The associations between 25 ( OH ) D and tau variables were not significant.
The associations between 25 ( OH ) D concentrations and measures of physical function were evaluated with unadjusted and adjusted regression models.
The associations between access to healthcare and health outcomes were generally stronger among older adults in rural areas than in urban areas.
The associations between alcohol consumption and depressive symptoms persisted over three years and were responsive to changes in alcohol-related categories.
The associations between blood pressure and dementia have been inconclusive.
The associations between declining muscle strength and mortality were assessed using a joint longitudinal and survival model.
The associations between depression and cognitive variables were attenuated when the models were adjusted for sensory impairment , physical health , and locus of control.
The associations between felt age and depressive symptoms were analyzed using stepwise linear regression analyses.
The associations between frailty and cognition were investigated using logistic regression.
The associations between frailty and other pathophysiologies has also been shown.
The associations between LTL and the lung function variables were weak.
The associations between patient age or pathological findings and tumor recurrence were determined.
The associations between PIMs use and health outcomes were largely inconclusive because of limited data.
The associations between RBCLS and inflammatory biomarkers were evaluated using linear mixed effects models.
The associations between selenium level and prevalent hypertension at baseline and between selenium and incident hypertension were examined.
The associations between the markers and survival time were investigated by Cox regression analyses.
The associations between these SNPs were analyzed by the Cochran-Armitage trend test , and results of the @number@ studies were combined with a meta-analysis.
The associations between the studied variables were assessed using multiple linear regression ( MLR ) analysis.
The associations did not vary with health status.
The associations in self-rated health and depressive symptoms were more pronounced in long-term caregivers than among those who recently started caregiving.
The associations may vary by APOE ε4 carrier status.
The associations of AL with cognitive abilities were not mediated by these brain volume measures.
The associations of beta blocker use and overall , CRC-specific , and recurrence-free survival were estimated by Cox proportional hazard regression.
The associations of BMI and height with global cognition and its five component domains were assessed by multiple regression.
The associations of COPD and disease duration with MCI and its subtypes were evaluated by using logistic regression models adjusted for potential covariates.
The associations of IELT and MELT with serum testosterone were measured.
The associations of physical and psychosocial work conditions with safety and health outcomes , e.g. , injuries , illnesses and job satisfaction , are presented.
The associations of these conditions with socio-demographics , type @number@ diabetes mellitus and depression were also studied.
The associations of vitamin D status with BUA and BMD were modified by BMI.
The associations persisted in fully adjusted models.
The associations were adjusted for age , systolic blood pressure and cholesterol level , using multivariate logistic regression analysis.
The associations were evaluated with overall breast cancer risk and with estrogen receptor negative and positive disease.
The associations were examined with multivariable logistic regression models.
The associations were not influenced by depressive symptoms.
The associations were partially attenuated when socioeconomic , family / social support , behavioral , and health-related covariates were individually taken into account.
The associations were partially mediated through walking difficulties , health and the sense of autonomy in participation outdoor activities.
The associations were significant and persisted after adjusting for confounders and a two-way interaction between cognitive ability and education.
The associations were similar , but statistically non-significant for obese men.
The associations were similar for FVC and persisted among lifetime never-smokers.
The associations with cognitive outcomes were independent of educational level , depression , and other SVD MRI markers.
The associations with higher adolescent and midlife BMI were both restricted to those with low childhood SEP ( p < @number@ for interaction ) .
The associations with mortality outcomes were much stronger among men than among women.
The associations with non-CVD mortality are weaker and not reach statistical significance.
The association varies considerably by time since interview and cause of death.
The association was attenuated when height was added to the model ( RR = @number@ @percent@ CI , @number@.98-1.14 ) .
The association was clearer for severe psychological distress ( OR : @number@ @percent@ CI : @number@.43-0.61 ) .
The association was consistent across age , history of diabetes mellitus , and physical inactivity subgroups.
The association was especially strong and consistent for memory recall with olfaction , explaining as much as @percent@ additional variance over and above general cognition.
The association was evaluated between anticholinergic drugs and cognitive performance in primary care patients with first cognitive complaints.
The association was maintained after additional control for cardiovascular risk factors ( β = @number@ P = @number@ ) .
The association was not modified by medication use or cognitive impairment.
The association was only slightly diminished-and many remained statistically significant-with further adjustments for psychological disposition and baseline health.
The association was seen mainly among those with diabetes mellitus.
The association was stable from young adulthood into midlife , and not weaker at age @number@ years.
The association with clinically relevant depression generally followed that with depressive symptoms.
The association with colorectal cancer prognosis remains widely unexplored.
The association with increased amyloid burden and Apolipoprotein E ε2 genotype supports cerebral amyloid angiopathy as the most common mechanism.
The association with macroscopic infarcts was driven by lacunar infarcts , and was independent of cerebral atherosclerosis and arteriolosclerosis.
The association with mortality appeared to be J-shaped for BMI , and linear for MNA.
The association with mortality seemed to be J-shaped for BMI , and linear for MNA.
The association with S-Cu remained statistically significant following further adjustment for hs-CRP in the same model.
The association with self-report mobility disability did not reach significance ( HR @number@ @percent@ CI @number@.99-1.20 ) .
The association with sulfates was stable across the moving averages.
The association with the number of falls was assessed using negative binomial regression.
The association with the other risk factors related to the metabolic syndrome makes the elderly more prone to the occurrence and development of cardiovascular diseases.
The association with white matter hyperintensity was no longer significant in models adjusted for cardiovascular risk factors and disease.
The associative fact did not affect young adults ' performance.
The assumption is that elderly people have specific financial needs that sometimes are not covered by financial providers ' offers.
The assumption of aerobic system linearity implies that the pulmonary oxygen uptake ( pV̇O2 ) dynamics during exercise transitions present a first-order characteristic.
The assumption that hypercholesterolaemia is a risk factor at the highest ages seems to be based on extrapolation from younger adults.
The astigmatic angle of posterior surface , GRIN lens , and homogeneous refractive index lens did not change significantly with age.
The astute practitioner will screen for depression in this population and appropriately treat to improve chronic illness management and quality of life in older adults.
The asymmetric distribution of damaged cellular components has been observed in species ranging from fission yeast to humans.
The asymmetric rate was assumed as the normal anatomic pattern.
The asymmetry occurred in all ages , being calculated as a percent rate for VD @percent@ , HD @percent@ , area @percent@ and perimeter @percent@.
The asymmetry of the mitochondrial fission is similar to that of their evolutionary ancestors , bacteria , which also undergo an aging process.
The asymptotic relative efficiencies and empirical biases under model misspecification are assessed for both proportional hazards and accelerated failure time models.
The asynchrony between host and malignant tissues in cell proliferation and metabolism also provides new and exciting options for novel anticancer therapies.
The AT1R A1166C gene polymorphism might modulate these changes in the Chinese.
The ATC , the ICD-10 and the PCNE Classification @date@ classification systems were used for medicines , health problems and DRP classifications , respectively.
The atherosclerosis of the penis that occurs with aging causes a decrease in penile oxygen tension.
The atherosclerotic wall might increase the occurrence of thrombembolic events or its rigidity might endanger the occlusion of perforators within the aneurysm vicinity.
The athletes also have a significantly lower adipose tissue than that of the physically untrained students and patients.
The Atlanta Regional Commission is replicating these best practices in other communities and providing support to those aspiring to launch or expand Lifelong Communities.
The atlas is based on the annotation of a few examples , and a large number of imaging data without annotation.
The ATM kinase is necessary for YAP and PML accumulation in WRN-depleted cells.
The atopic status , CF genotype and drug history were recorded for each patient.
The ATRI is slated to play a central role in clinical dementia research in the US in near future.
The ATRI will share all relevant data and materials with the academic community , corporations , and government organizations.
The atrophy of senescence was treated by adding volume to the lips and filling the deep nasolabial creases.
The atrophy pattern associated with the AD-CSF index was highly symmetrical and corresponded with the typical AD signature.
The ATR will collect longitudinal data on lifestyle , including diet and activity levels , aging , complex traits , and diseases.
The attachment-focused integrative reminiscence ( AFIR ) intervention differs from these in its central emphasis on attachment themes.
The attachment patterns of younger and older adults were studied using two-dimensional self-report measures of adult attachment.
The attempted separation of DA from object anxiety is a significant difficulty.
The attempt of this paper is to overcome this gap by exploring how gender intersects with the loss of bodily autonomy experienced by hospice patients.
The attempt of this study is to determine the optimal time to begin prevention of osteoporosis.
The attendant changes represent a mix of gains and losses for women , in which not all women have benefited ( or suffered ) equally.
The attentional capacity for such dynamic tracking , however , is highly limited and undergoes age-related decline.
The attentional cost involved was higher than for the first task.
The attentional demands were further elevated during cued walking , with larger RTs for walking to visual stepping stones than to metronome beeps.
The attention control consisted of weekly educational lectures by clinicians for @number@ months.
The attention received by both conditions derives from their strong association with disability , hospitalization , and death.
The attenuated cardiovascular adjustments in the aged could be due to lower increases in sympathetic nerve activity during heat stress.
The attenuation of the hsCRP-MI association by these three metabolites indicates a potential link to systemic inflammation.
The Attitudes to Aging Questionnaire measured participants ' attitudes toward physical change , psychosocial loss , and psychological growth.
The attraction to and promise of BHRT is rooted in the idea that it is a \ "natural \ " therapy.
The ATTR is an efficient tool for the assessment of temporal resolution at both ends of the lifespan.
The ATXN2 CAG repeats were amplified using polymerase chain reaction.
The AUC0-2h ( n = 11 ) was @number@.67-3.51ng / mL.
The AUC for gender , age and body mass index ( BMI ) in prediction for KOA was @number@
The AUC in the external validation data set was @number@ for the < 50-nmol / L model.
The AUC of MEWS in predicting in-hospital mortality was @number@ ( @percent@ CI , @number@ @number@ ) .
The AUC of the MMSE was @number@ ( @percent@ CI : @number@.74-0.89 ) .
The AUC values for hip fractures were @number@ for Garvan nomogram and for @number@ FRAX , and did not differ.
The AUC was @number@
The audiological data show that the percentage of impaired people increases with age and in particular becomes relevant aged over @number@
The auditory-frontal cortical network involved seems , therefore , to play a pivotal , unifying role in the different abnormalities.
The auditory periphery exhibits a progressive bilateral , symmetrical reduction of auditory sensitivity to sound from high to low frequencies.
The augmented Victoria Longitudinal Study Activities Questionnaire was used to quantify level of engagement in physical activity , sociocognitive activity , and TV viewing.
The Austrian LEAD study has been initiated in the general population @number@ to investigate the natural history of obstructive airway diseases.
The author assessed the driving behaviors of a sample of @number@ men and women.
The author discusses recent developments in the perspective of Alzheimer disease pathogenesis and potential therapeutic interventions.
The author emphasizes that there is a need to update current definitions of aging , or to formulate new multidisciplinary ones.
The author estimates , based on prior experience , that duration of effect will be approximately two to three years.
The author has discussed patients with these complaints : their epidemiology , pathophysiology , and management in the emergency department.
The author illustrates how the act of writing a memoir can be an important tool in resolving questions of identity.
The author managed five hematoma cases in which surgery to the neck was performed.
The authors addressed quality improvement issues identified by the Institute of Medicine and our health network.
The authors advocate a long follow-up for pediatric patients with shunts in situ to monitor them for various causes of late shunt failure.
The authors agree that medication management abilities decrease as cognitive impairment increases , even if a lot of studies assess only the physical dimension.
The authors aimed to describe the reliability and validity of the MMSE as a measure of cognitive function among healthy older adults.
The authors aimed to give a focus on the particularities of each of the issues addressed.
The authors ' aim was to determine the evolution of subcutaneous fat in the aging upper face , focusing on shifts in volume and dimension.
The authors ' aim was to measure the seated sway of typically developing children using a multisegment approach.
The authors also analyzed in how smoking , age , and skin properties might affect the clinical outcome.
The authors also conclude that general practitioners require more guidance from haematologists in the management of patients with very high values.
The authors also conducted Google and other online searches to supplement study findings.
The authors also discuss how to engage older adults in participatory research.
The authors also draw on qualitative research to examine the transmission of ideology and rhetoric in self-skills training.
The authors also intend to gauge the evolution of older patients ' admission profile over @number@ years , in the same clinical setting.
The authors also observed that maxillary bone thickness increased toward the upper areas of the lacrimal sac fossa and with increasing subject age.
The authors also performed Pittsburgh Compound B ( PIB ) imaging among seven cognitive impaired patients with stroke.
The authors also studied the relationships between these dispositions and the adolescents ' spending preferences and ability to control spending.
The authors analyse the relatively scarce legislation about this topic at both national and regional level.
The authors analyzed data by using descriptive statistics , the Mann-Whitney test , the Kruskal-Wallis test and a χ ( @number@ ) test.
The authors analyzed pre- and postsurgical photographs of @number@ patients with a Lipo-Facelift after @number@ and @number@ months and analyzed their charts for complications.
The authors analyzed results and complication rates of two methods for hollow eye ring treatment.
The authors analyze surveys administered to Dutch employers in @number@ @number@ @number@ @number@ and @number@
The authors analyze the effect of participation in short-term training measures on older German recipients of means-tested unemployment benefits.
The authors believe the technique described is another option for approaching and fixating the eyebrow.
The authors carried out a psychophysical experiment with the method of binocular observational technique.
The authors compared cytokine levels , examined demographic and clinical associations , and adjusted for relevant variables with linear models.
The authors compared the findings with data from their previous study of centrifuge-processed fat grafts ( historical controls ) .
The authors compared the ratio of vertical to horizontal eye movement ( height / width defined as aspect ratio ) in normal and test subjects.
The authors concluded that age at release is a poor index of within-subject changes in risk of sexual or violent recidivism.
The authors conclude that better coordination and systematic funding of research in gerontology is needed because of the actual demographic challenges.
The authors conclude that desisting from delinquency is an important part of the package of role behaviors that define adulthood.
The authors conclude that few studies have tested whether BDNF mediates age-related hippocampal atrophy and memory impairment.
The authors conclude that mucin deposits in the legs are not inherent to aging.
The authors conducted a study to find out the different causes of late shunt failures in their institution.
The authors conducted telephone interviews , using random digit dialing , of @number@ adults aged @number@ and over in the city of Hamilton.
The authors consider that the knowledge gap in this area requires attention of all stakeholders in the healthcare community.
The authors created a final model based on multivariable risk factors.
The authors declare no competing financial interests.
The authors declare that there are no conflicts of interest.
The authors describe and evaluate the impact of a 3-year , university-community SWF collaboration on interprofessional competencies among students across multiple professional programs.
The authors describe a technique for improving the obtuse cervicomental angle.
The authors describe the creation and monitoring of an enhanced surveillance system concerning Iowa's dentists.
The authors determined agreement using absolute agreement.
The authors developed a controlled DCD protocol in which comfort therapy is regularly used.
The authors developed , implemented , and evaluated a QI curriculum for geriatrics fellows.
The authors discussed important implications for future research and social policy.
The authors discuss implications for potential knowledge transfer for cost minimization and medical tourism.
The authors discuss the current state of cognitive therapeutic interventions and then present the need for development and validation of more powerful neurocognitive therapeutics.
The authors discuss the evidence supporting the involvement of the IIS pathway in modulating the PN and regulating proteostasis in Caenorhabditis elegans.
The authors discuss the implications of their findings for the ongoing discussions on the ecological approach to learning.
The authors discuss the nonsignificant findings between telomere length and cognitive assessments including the potential modifying role of gender.
The authors discuss the prevalence of androgen deficiency and its relationship with age , concomitant diseases , pharmacotherapy and other factors.
The authors discuss these findings and their implications for the assessment of late-life social anxiety.
The authors discuss the specific driving risks adults face as they age and how nurses can raise older patients ' awareness of these risks.
The authors distinguish between ER visits linked to a hospital admission for that individual and ER visits not linked to an admission.
The authors divided the task into @number@ phases ( accelerated , decelerated , and steady ) based on the relationship between COM and COP.
The authors educated chief residents about value-based care , linking them to key interprofessional staff to build team-based care.
The authors employed a battery of @number@ widely utilized clinical cognitive tests.
The authors employed qualitative analytic techniques using an interdisciplinary team process.
The authors evaluated the association between BMI and aspects of ABPM together with their associations with cardiac remodeling in @number@ patients.
The authors evaluate the repercussion of hypoestrogenism and sexual steroids on some elements of the pelvic floor and lower urinary tract.
The authors examined age-related differences in fine motor control during a bimanual coordination task.
The authors examined associations of infarcts , white-matter lesions ( WML ) and atrophy at different locations with depressive symptoms and cognitive functioning.
The authors examined how lexical characteristics affect speech output in individuals with Parkinson's disease ( PD ) and healthy control ( HC ) speakers.
The authors examined if older adults would show a lexical-only parafoveal benefit.
The authors examined longitudinal change in positive affect ( PA ) , a component of subjective well-being.
The authors examined risk factors , including mental disorders and dementia , for hospitalization of Medicaid-enrolled NH residents with ACS conditions during fiscal year 2003-2006.
The authors examined the association between birth month and longevity for major league baseball players.
The authors examined the neural correlates of emotion processing and how they relate to individual differences in optimism among older adults.
The authors examined the relationship between the sex composition of offspring and parental survival in contemporary China and Taiwan.
The authors examined the role of anesthetic management in optimizing the microcirculation and potentially improving postoperative wound repair in older persons.
The authors examined the self-adhesive resin composite cements without ( @number@ ) and with ( @number@ ) the use of a ceramic primer.
The authors examine these issues through the lens of sociopsychological identity theory , specifically examining how identity threat influences academic physicians ' decisions about retirement.
The authors ' findings have important implications for education and practice.
The authors ' findings illustrated the distribution of ISLD grades.
The authors find that those near retirement could fare the worst because they have no time to recoup their losses.
The authors found domain-specific lead-lag associations ( time lags of @number@ years ) among wives and husbands as well as between spouses.
The authors give particular attention to illnesses , including Alzheimer's disease , Parkinson's disease , skin aging and cardiovascular diseases.
The authors have been performing autologous fat grafting for facial rejuvenation for @number@ years and the procedure has evolved significantly during this time.
The authors have developed power assist suits named \ "smart suit \ ".
The authors have illustrated different approaches that can act on NSPs , modulating the rate of the aging process.
The authors have indicated no significant interest with commercial supporters.
The authors have indicated no significant interest with commercial supporters.
The authors have indicated no significant interest with commercial supporters.
The authors have no potential conflict of interest to declare.
The authors have used the unique capabilities of the three-dimensional camera to average the faces of large numbers of subjects to understand this complex process.
The authors hypothesized that a frailty index can predict postoperative outcomes after pancreaticoduodenectomy ( PD ) .
The authors hypothesized that age may be an important modulating factor in this relationship.
The authors hypothesized that cells in the mesenchymal compartment of dental pulp attenuate osteoclastogenesis.
The authors hypothesized that high school students would be less knowledgeable about memory aging issues than college students , middle-aged , and community-dwelling older adults.
The authors hypothesized that older adults exert more listening effort compared with young adults.
The authors hypothesize that admission frailty assessment would be predictive of outcomes in the elderly burn population.
The authors identified at least one ACS hospitalization in @number@ residents for a total of @number@ hospital admissions ( @percent@ of all hospitalizations ) .
The authors identify key success factors that made the transformation possible , as well as challenges and work that remains to sustain the change.
The authors illustrate this using @number@ case studies of couples who sought guidance in the area of sexuality.
The authors integrate their knowledge to describe how the technique of one of the senior authors ( R.J.R. ) has evolved over time.
The author's intent for this review is to provide an historical overview of the field of embryonic stem cells with relation to the retina.
The authors investigated cognitive predictors in patients with confluent WML.
The authors investigated normative beliefs about personality development.
The authors investigated the association between CSVD and incident depressive symptoms.
The authors investigated the combined age and HIV effects on cognitive functions in @number@ individuals , @number@ of whom had HIV infection.
The authors investigated the impact of knowledge of carrying the risk allele on subjective ratings of memory and objective memory test performance of older adults.
The authors investigated the relative effectiveness of different attentional focus instructions on motor learning in primary school children.
The authors investigated the use of Google Earth's Street View option to audit the presence of built environment features that support older adults ' walking.
The authors investigated this question in an epidemiologically defined cohort with psychotic disorders followed for @number@ years after first hospitalization.
The authors investigated whether age differences in the recall of original judgments account for this difference.
The authors investigated whether executive attention could be improved in healthy older adults following brief exposure to nature pictures.
The authors investigated whether incidental task structure was differentially beneficial to younger and older adults.
The authors investigated whether young adult survivors of childhood acute lymphoblastic leukemia ( ALL ) have a biologic phenotype of cellular ageing and chronic inflammation.
The authors might have explored why ( as they argue ) public policy has retreated from their prescription in recent decades.
The authors observed positive significant relations between distant caregiver negative health perceptions and conflict frequency and usage of the distributive and avoidance conflict strategies.
The authors of the current study combined these tasks to create a Stroop switching task.
The authors of these articles offer novel insights into the theoretical underpinnings of spousal interrelations as well as how to approach such issues analytically.
The authors present a case of cytomegalovirus encephalitis and hepatitis , due to viral reactivation associated with development of secondary immunodeficience in an HIV-negative patient.
The authors present a reproducible and effective technique utilizing poly-L-lactic acid for panfacial revolumization.
The authors previously suggested this location as significant for cross-facial nerve coaptation.
The authors projected to @number@ nationwide age-standardized incidence rates and cases ( including the top @number@ cancers ) .
The authors propose a mathematical model of the influence of the environment on the aging of living systems.
The authors propose several recommendations for tackling new approaches and applications.
The authors propose that an age-related decline in the integrity of body-schema information may account for this change.
The authors propose that CST ranges from @number@ μm to @number@ μm in normal eyes.
The authors propose that this method is more sensitive and versatile than using SBB alone.
The authors provided cross-ethnicity replication in the MESA Hispanic-American participants.
The authors provide four points that should be considered in any neck-lift procedure.
The authors ' purpose was to evaluate the geriatrics clerkship's impact on internal medicine knowledge and medical student attitudes toward older adults.
The authors ' purpose was to explore the role of parenting in the intergenerational transfer of economic orientation and economic behavior.
The authors reason that increased effort in cycling might benefit overall times of older triathletes.
The authors recommend combined craniofacial approach to achieve good outcome and decrease the incidence of complications.
The authors recommend that the MNA should be routinely applied by the nursing staff.
The authors report no conflicts of interest.
The authors reviewed the literature to examine the relationship between brain-structure size and cognitive performance in older adults.
The authors reviewed the medical records of @number@ consecutive patients who underwent transcutaneous lower eyelid blepharoplasty with orbitomalar suspension.
The authors review the evidence on the situation in Portugal and propose an intervention plan.
The authors see this phenomenon as a potential but largely unrecognised ' fourth digital divide ' which has serious implications for social inclusion.
The authors set out to quantify the health state utility outcome assessment of living with arm deformity requiring brachioplasty.
The authors sought to analyze medical students ' journals regarding their mentored experiences within a new geriatrics curriculum at a U.S. medical school.
The authors sought to describe current geriatric psychiatry teaching practices during the psychiatry clerkship.
The authors sought to determine which neuropsychiatric symptoms predict relapse.
The authors sought to examine the clinical efficacy , complication rate , and cost-effectiveness of rhBMP-2 use in elderly patients undergoing spinal fusion surgery.
The authors sought to investigate whether the obesity paradox also applies to intracerebral hemorrhage ( ICH ) survivors.
The authors sought to measure whether these changes in individuals with schizophrenia remain stable , are accelerated , or are diminished with age.
The authors speculate an IFN-dependent mechanism that plays a role in the aging process and cognitive decline.
The authors studied the effects of aging on the flexible use of categorization rules based on thematic and taxonomic relations.
The authors suggest maximizing residents ' independence to stabilize care dependency and improve incontinence care.
The authors suggest that in order to avoid possible risks of AMD development , people who frequently take ASA should have their vision checked regularly.
The author states , that the thermodynamics is driving power of evolution and development.
The authors tested an alternative formulation of this model : genes may buffer against depressogenic effects of life stress.
The authors tested the notion that older adults may also have difficulty perceiving the postural constraints associated with reach estimation.
The authors therefore recommend recording motor axonal excitability in various muscle groups rather than a single muscle group.
The authors think that this dramatic improvement is owing to multiple factors.
The authors treat these areas , however , as part of a current philosophy of smaller volumes over larger areas.
The author suggests that ( besides biology , psychology and sociology ) the technological discipline should be included in the integrative gerontology model.
The authors used an appraisal point system to evaluate the quality of the studies.
The authors used Cox proportional hazard regression to assess time to the first ACS hospitalization.
The authors used data from a sample of the Scottish Mental Survey , @number@ to study personality stability from childhood to older age.
The authors used these interviews to identify major themes and discuss implications for population health.
The authors we achieved @percent@ follow-up with @percent@ patient satisfaction.
The authors were concerned that , in an increasingly comorbid population , this method of raising help was not fit for purpose.
The automated characterization enables objective evaluations of alpha band activities over large samples.
The automated electronic search algorithm for cognitive impairment was @percent@ sensitive and @percent@ specific.
The Automated Self-Administered 24-hour ( ASA24 ) Dietary Assessment Tool is a web-based system that guides respondents through 24-h recalls.
The automatic calculations of brain volumes took approximately @number@ minutes per investigation.
The automotive safety community has been interested in understanding the effect of age on restraint performance.
The autonomic nervous system activity was assessed through 24-hour heart rate variability and 15-minute spontaneous baroreflex sensitivity at baseline.
The autonomic nervous system is a key regulator of the cardiovascular system.
The autonomic nervous system plays a central role in both acute and chronic blood pressure regulation in humans.
The autophagosomal pathway can be further activated in response to elevated levels of reactive oxygen species ( ROS ) .
The autophagy-lysosome system is an essential pathway to get rid of unwanted cellular components ( proteins and organelles ) .
The autophagy-mediated switch to an irreversible presenescent state of geriatric satellite cells appears to play a key role in age-related impaired satellite cell function.
The auto-polymerized cement showed an increase in opacity.
The autopsy confirmed prion disease pathology.
The availability of an adequate household food supply is critical for the older population.
The availability of and demands for energy constitute one of the most important aspects of the environment.
The availability of auditory rehabilitation has significantly improved with the current legislation.
The availability of dermal fillers for multiple cosmetic indications has led to a dramatic increase in their application.
The availability of diverse options would help fit the needs of a heterogeneous population.
The availability of family can be considered a protective factor for aging well.
The availability of human stem cells heralds a new era for in vitro cell-based modeling of neurodevelopmental and neurodegenerative diseases.
The availability of multiple insulin products provides new opportunities to achieve control of diabetes mellitus.
The availability of tools to identify frail people is relevant for both research and clinical purposes.
The available clinical trials that have specifically studied the elderly with lung cancer are summarized.
The available data indicate that these pathways will be fruitful areas for study in the modification of renal disease.
The available data on the effectiveness of therapeutic hypothermia in different patient groups are heterogeneous.
The available data strongly suggest significant effects at the molecular level that represent interactions with the epigenome.
The available data suggest that further investigations will be required to ultimately develop a standardized thermal cycling protocol.
The available evidence of a possible association between anesthesia , surgery , and long-term cognitive effects , including AD , deserves consideration.
The available evidence suggests that current management of patients with PD in LTC facilities is less than optimal.
The available literature confirms this expectation.
The available published data generally indicate that stiffness varies spatially within the lens and that stiffness parameters tend to increase with age.
The available treatment modalities that provide desirable results are often overtly invasive and entail a risk of undesirable adverse effects.
The available TST agents have changed significantly over the past decade similar to the trends in the diagnosis of TD.
The average absolute difference between two successive HBF measures was @number@ mL / ( @number@ g min ) or @percent@.
The average age at baseline is similar across cohorts ranging between @number@ and @number@
The average age at death was @number@ years.
The average age at onset of this family was @number@ years.
The average age at onset was @number@ years.
The average age in @number@ was significantly younger than in @number@ ( @number@ vs @number@ years , P < @number@ ) .
The average age of dentists changed from @number@ years in @number@ to @number@ years in @number@
The average age of donors was @number@ years ( range , 18-68 years ) .
The average age of golfers was @number@ years ( range , 32-79 years ) .
The average age of patients was @number@
The average age of patients was @number@ ± @number@ years.
The average age of students was @number@ years.
The average age of subjects with a high AIX was @number@ y ± @number@ y.
The average age of the older residents was @number@ ± @number@
The average age of the patients in the THA studies ranged from @number@ to @number@ years.
The average age of the study population was @number@ years and @percent@ was male.
The average age of those attending HIV clinics has therefore increased , with this trend expected to continue into the future.
The average age of women having their first child has been rising in recent decades [ @number@ ] .
The average age of women was @number@ ± @number@ years , men @number@ ± @number@ years.
The average age reductions across the DA system were @number@.7%-14.0% per decade.
The average age values calculated according to the three methods were compared with the values of known age.
The average age was @number@.02years and most were males ( @number@ patients ; @percent@ ) .
The average age was @number@ but with many in their 40s when the diagnosis of ' late onset hypogonadism ' is not generally considered.
The average age was @number@ ± @number@ years old with @percent@ of women ( n = @number@ ) .
The average age was @number@ years and average maximum flow rate was @number@ mL / s.
The average age was @number@ years , and most individuals were women ( n = @number@ @percent@ ) .
The average age was @number@ years , and @percent@ were men , @percent@ were women , and @percent@ were transgender or intersex.
The average amount consumed declined with advancing age , regardless of the presence of any of the eight most common chronic diseases.
The average amplitude of the rectified submentalis muscle EMG signal was then obtained for all 1-s mini epochs of REM sleep.
The average annual 1975-2009 rates for females and males were @number@ and @number@
The average annual cost of dementia was @number@ Euros per patient living at home and @number@ Euros per patient living in nursing homes.
The average annual percentage change in hospitalization rates was used to highlight any significant change in time trends.
The average available length of GEA is @number@ mm ( range : 210-280 mm ) .
The average CT of the PACG eyes at each location was compared to that of normal eyes.
The average daily cost of care during the last @number@ days did not differ significantly between the two groups.
The average daily dose of thyroxine ( @number@ µg ) roughly corresponded to @number@ µg / kg.
The averaged difference between dominant and non-dominant side was non-significant.
The averaged difference between male and female was significant , with males being faster than females for both hands and feet.
The average delay in diagnosis of ACA was @number@ years ( range @date@ years ) .
The average diameter and area of a red blood cell population were ascertained to correspond to the generally accepted adult upper normal ranges manually calculated.
The average difference between the observed and expected NGF count was @number@ ( @percent@ CI , @number@ @number@ ) .
The average division of TM / CAM use was @number@ modalities in the null model and @number@ in the full model.
The averaged Thompson's grade was found to be @number@.9±1.3.
The average duration from initial symptoms to cognitive decline is @number@ months , ranging from @number@ to @number@ months.
The average error in cortical bone area between the predicted geometries and a validation set of cadaver femur geometries across @number@ shaft locations was @percent@.
The average error in midshaft cortical bone areas between the predicted geometries and the patient geometries was @percent@.
The average estimated cost of a rapid review was C $ 11 , 646 ( SD = C $ 10 , 914 ) .
The average estimated time to complete retirement was @number@ years.
The average estradiol levels were similar in both the active group and placebo group after treatment.
The average Falls Efficacy Scale score was significantly higher in fallers ( P = @number@ ) .
The average fat grafting volume was @number@ ml per hand dorsum administered in one or two procedures.
The average Florida NH had @number@ beds , and @percent@ of its residents were classified as low-care.
The average formal quality score was better after the distribution of the booklet increasing form @number@ to @number@ points ( p < 10⁻⁴ ) .
The average heights of adult men and women were @number@ and @number@ cm , respectively , with wide variation among states.
The average hip ROM decreased from 380° in average pre-surgery to 200° in average at last follow-up.
The average human lifespan has increased throughout the last century due to the mitigation of many infectious diseases.
The average ILA was @number@.45° ± @number@ and @number@.25° ± @number@ for males and females , respectively ( P < 10-25 ) .
The average IMD consists of @number@ internists with one-fifth of the hospital beds.
The average increase in malar projection was @number@ cm for the right cheek and @number@ cm for the left cheek.
The average inter-expert agreement was 61±6% ( κ : @number@.52±0.07 ) .
The average iodine intake of the patients with hypothyroidism and euthyroidism was @number@ μg and @number@ μg , respectively.
The average LFT was @number@ ± @number@ mm in the control group and @number@ ± @number@ mm in the LCSS group.
The average life expectancy and the proportion of the elderly in the Western countries are increasing.
The average lifespan of humans and the percentage of people entering the @number@ and older age group are growing rapidly.
The average lifetime risk of developing Alzheimer disease is 10-12%.
The average men's arch also had a more acute angle at the apex ( @number@.7° vs @number@.7° p < @number@ ) .
The average methadone dose ( p < @number@ ) and the 1-year retention rate ( p < @number@ ) also increased significantly.
The average mortality rate was @percent@ , but it significantly decreased after new anticoagulants were approved in @number@
The average number of brain contusions on CT / MRI was approximately the same.
The average number of medications per subject was @number@ and it was higher in women ( @number@ ) than in men ( @number@ ) .
The average number of needs reported was @number@ comprising @number@ met needs and @number@ unmet needs.
The average number of years in education was @number@ ( standard deviation = 5.2 ) .
The average observation period for the @number@ patients was @number@ months.
The average observation time of both groups was @number@ years , and mean age was @number@ years , by the end of the observation period.
The average of urban household carbon emissions in the region was estimated to be @number@ tonnes CO2 in @number@
The average out-of-pocket health expenditure was Chinese Yuan ( Y ) @number@ ( Y100 = $ US12.2 in @number@ ) .
The average participant was @number@ years old , and the sample consisted of @number@ males and @number@ females.
The average peak width at half height was 340ms and the average tailing factor was @number@
The average pigment improvement score was @number@ ± @number@ on a 4-point scale.
The average pigment improvement score was @number@ ± @number@ ( P < @number@ t-test , n = @number@ ) .
The average postmortem interval was @number@ h.
The average preoperative computed tomographic effective dose was @number@ mSv ( 18-81 ) .
The average procedural pain scores for the cheek , submental , and submandibular regions were @number@ @number@ and @number@ respectively.
The average proximal diameter is @number@ mm , and the distal diameter is @number@ mm.
The average QoL score in the sample was @number@ ( 95%CI : @number@ @number@ ) .
The average Q values of the posterior surface at @number@ @number@ and @number@.0mm were @number@.26±0.216 , @number@.26±0.214 , and @number@.26±0.215 , respectively.
The average rate of change per year across frequencies and age was @number@ dB.
The average rate of descent was @number@ mm per year.
The average rate of perioperative PTE was estimated to be @number@ per @number@ operations between @number@ and @number@
The average rates of decline in distensibility ( @date@ OBJECTIVE : To determine age-based criteria for polycystic ovary morphology.
The average reduction in apparent age after a facelift alone was @number@ years.
The average reduction in working life expectancy was @number@ years.
The average resection width was @number@ mm ( 8-15 mm ) .
The average respondent was @number@ years old and worked @number@ clinical and @number@ non-clinical h per week.
The average RNFL thickness ( mean ± SD ) was @number@ ± @number@ μm.
The ' average R / S ' subtype had significantly greater life satisfaction than their ' low R / S ' counterpart.
The average RT for older and younger participants was not different.
The average saccade latency ( measured by video-oculography ) was longer in the elderly , and irrespectively of the condition.
The average salt intake in the Netherlands is well above the nationally recommended maximum intake of @number@ grams per day.
The average score for social capital was @number@ points of a maximum of @number@
The average size of corneal endothelial cells directly correlated with age ( r = 0.586 , P < 0.01 ) .
The average size of decorin protein did not alter , indicating size of GAG chain is reduced in aged , compared to young skin.
The average skin resection was @number@ mm for the primary and @number@ mm for the secondary rhytidectomy patients.
The average somatic and sexual subscore was significantly higher in group I ( P < @number@ ) .
The average survival after baseline was @number@ years ( SD = @number@ ) .
The average swallowing duration measurements increased with age.
The average telomere length declined with age at a rate that differed between age-specific breakpoints and between cell types.
The average thickness of skull at the anterior midline varied from @number@ mm ( 0-9 years ) to @number@ mm ( 80-89 years ) .
The average thickness was calculated from enhanced depth SD-OCT images and manually analyzed with Image J software.
The average time elapsed between their previous and last rhytidectomy was @number@ years.
The average time from first noticing symptoms to diagnosis varied from @number@ to @number@ weeks.
The average time of the interaction between ritonavir and fluticasone was @number@ months.
The average time since diagnosis was @number@.9±3 years.
The average tumor size for the GE group was significantly decreased compared to the non-GE group.
The average value of global SOC was @number@ the standard deviation @time@ ; discrepancy @number@ ( minimum @number@ and maximum @number@ ) .
The average volume in the CCS @number@ group was @number@ cc , while in the PPH-01 it was @number@ cc and difference was statistically significant.
The average volume required ranged from @number@ to @number@ ml of filler.
The average weight regain during follow-up was @number@ kg less in the SRI + DIET + EX group.
The average window shapes did not differ between normal-hearing and hearing-impaired groups ; however , there was large individual variability.
The AVL and NAS were adapted for use in Spain.
The awakening of telomerase during carcinoma initiation and development is being seen with different perspectives including genetic and epigenetic tools and events.
The awareness of qualia was found to be more varied among subjects compared to the belief in free will.
The awareness of qualia was found to increase significantly with age , suggesting a continuous learning process.
The awareness of the phenomenal qualities of one's experiences can be considered as an instance of metacognition.
The axis ossified from @number@ OCs and @number@ synchondroses.
The axis recovered completely.
The axis tilt in the principal axis direction was assessed by calculating the coordinate Y-axis and X-axis tilt.
The axonal response to losing specific proteins also depends on the rates of protein turnover and on whether the protein can be locally synthesized.
The axon terminals of the glutamatergic cortico-striatal projection neurons were quantified at the striatum using antivesicular glutamate transporter-1 ( VGLUT-1 ) immunohistochemistry.
The azimuth measure correlated with the GDS score , and pressure with the MMSE and the GDS scores.
The azuki bean ( Vigna angularis ; VA ) has been widely used as a food product as well as a traditional medicine.
The Aβ42 / Aβ40 ratio was superior to Aβ42 concentration with regard to identify incipient AD in MCI.
The Aβ42-induced PS1 increase was abolished by siRNA AChE pretreatment , suggesting that AChE may participate in the pathological feedback loop between PS1 and Aβ.
The Aβ level was measured according to a summary distribution volume ratio of frontal , lateral temporal and parietal , and retrosplenial PiB-PET tracer uptake.
The Aβ-peptide is believed to be the major pathogenic compound of the disease.
The Aβ peptides aggregate to form soluble oligomers and finally deposit into amyloid plaques that are a hallmark of AD.
The baby boom generation began turning @number@ in @number@ and is now driving growth at the older ages of the population.
The BACE1 cleavage site mutation 1008MM / AA dramatically impaired soluble contactin-2 release.
The backbone of K6W-Ub is indistinguishable from that of Wt-Ub.
The back-scratch test revealed an improvement only in AG ( @percent@ ; P < @number@ ) , while the sit-and-reach test improved in all groups.
The bacterial flagellae are essential to move the bacteria towards the epithelial surface.
The bacterial genotoxin colibactin , encoded by the pks genomic island is frequently harboured by Escherichia coli strains of the B2 phylogenetic group.
The bacteria VacA and CagA are cytotoxic factors.
The bacterium Wolbachia ( order Rickettsiales ) is probably the world's most successful vertically-transmitted symbiont , distributed among a staggering @percent@ of terrestrial arthropod species.
The balance between cell survival and death leaves an ovarian follicular reserve as a legacy.
The balance between endogenous activators and inhibitors of angiogenesis delicately maintains a normally quiescent vasculature to sustain homeostasis.
The balance between osteoblasts and adipocytes is influenced by a reciprocal relationship.
The balance between self-renewal and differentiation is achieved through control of cell division mode , which can be either asymmetric or symmetric.
The balance between self-renewal and differentiation is considered to be critical to the maintenance of stem cell numbers.
The balance between treatment efficacy and quality of life is a major focus because of the shorter life expectancy of patients.
The balanced cardiomyogenesis ( cardiomyocyte hypertrophy and hyperplasia ) and neo-angiogenesis are essential determinants for exercise-induced cardiac growth.
The Balanced Scorecard or Integrated Scorecard of the integration process was introduced as it has been designed.
The balance of evidence indicates that early therapy is essential to delay the accumulation of irreversible neurologic damage and consequent disability.
The balance of omega-6 and omega-3 FA is important for homeostasis and normal development throughout the life cycle.
The balance reactions of participants in both groups improved ( p < @number@ ) .
The BAPs revealed @percent@ of the differences between day @number@ and @number@ scores were within the @percent@ confidence interval of the mean difference.
The barium esophagogram and direct laryngoscopy are the most useful diagnostic tools.
The baroreflex slope ( BRS ) and baroreflex effectiveness index ( BEI ) were determined using the sequence method for baroreflex sensitivity.
The barriers to accessing planned healthcare for older people with ID need more investigation.
The barriers were identified by participating in the program and interviewing ministry , program and project actors.
The Barthel Index and Lawton IADL scale are recommended for future use in research and clinical practice in this group.
The Barthel score was the characteristic most strongly associated with grip strength.
The basal AMH , AFC and maximum serum level of 17β-estradiol before pickup continue to show higher correlation to pregnancy rate.
The basal and stimulated content of cGMP in HCC was significantly decreased in patients with ED , but specially reduced in diabetic patients.
The basal forebrain volumes of AD and aMCI subjects were significantly reduced compared to those of control subjects.
The basal ganglia nuclei are critical for a variety of cognitive and motor functions.
The base-case population consisted of men and women aged @number@ years with a hip fracture.
The base cohort included Medicare beneficiaries aged ≥65 years , diagnosed with depression as of @number@ and with any MDS assessment in @number@
The baseline and post-treatment sebum production was measured using a Sebumeter.
The baseline assessment , Wave @number@ was conducted in @number@ and follow-up assessment , Wave @number@ was conducted in @number@
The baseline characteristics , the prescriptions and the treatment outcome were compared.
The baseline concentrations of Aβ40 were similar in all MCI groups.
The baseline DDD could be a valuable parameter accessing their microvascular circulation.
The baseline DDD was greater than @number@ °C in @percent@ of the patients.
The baseline duct sizes for patients with gallstones were not significantly different from those who never had gallstones ( P = @number@ ) .
The baseline estimate of the cost per life-year gained from pharmaceutical innovation is $ 2776.
The baseline evaluation was carried out in @number@ and the follow-up in @number@ and @number@
The baseline examination included a questionnaire and a clinical and functional examination.
The baseline prevalence of T. cruzi infection was @percent@ and the overall mortality rate from stroke was @number@ per @number@ person-years.
The baseline sample included @number@ assessments while the 6-month follow-up sample of persons still being served by the home care agencies consisted of @number@ assessments.
The baseline serum total and high molecular weight adiponectin were measured using an enzyme-linked immunosorbent assay.
The baseline study collects biomarker-based data on HIV , ART , diabetes , and hypertension and self-reported data on health care utilization.
The baseline study included self-reported oral health measurements , and clinical oral health measures were introduced in @number@
The baseline survey was conducted partly in @number@ and partly in @number@ and the follow-up survey was conducted in @number@
The baseline visits occurred from @date@ through @date@ .
The basic analytic approach was based on an intention-to-treat analysis.
The basic and instrumental activities of daily living were assessed ( ADL , IADL ) .
The basic approach to the treatment of Wernicke-Korsakoff syndrome is long-term parenteral administration of thiamine , often in high doses.
The basic group was made of @number@ patients aged 60 + years , @number@ patients younger than @number@ years were included in the control group.
The basic LTC building blocks housing , services , and medical care can be combined in various ways to meet consumers ' needs and preferences.
The basic premise is that congruency between the recipient's cultural characteristics and the respective message will increase the communication's effectiveness.
The basic principles of management , especially in the fit elderly , do not differ from those in younger patients.
The basic science of sensory impairment and social engagement in people with dementia needs to be developed.
The basic social process named \ "changing focus \ " that women use as they negotiate the perimenopausal transition is discussed.
The basic tenets of their arguments favour considering cancer as a cell-based , genetic disease whereby DNA mutations cause uncontrolled cell proliferation.
The basis for pathogenesis is unknown.
The basis for the petition was that the MS patient had a significant reduction is his mental competence.
The basis of the age-related toxicity partly resides in age-related mitochondrial dysfunction and an oxidative shift in mitochondrial and cytoplasmic redox potential.
The basis of this relationship with survival is not known ; however , systemic inflammation may reflect comorbidity.
The battery free sensor module could improve the wearability of the wireless device.
The battery was compared to in-person standard assessments of cognition and FC with respect to baseline convergence and sensitivity to group differences.
The Bayesian False Discovery Probability ( BFDP ) was computed to assess the noteworthiness of the results.
The Bayesian inference using WinBUGS is also discussed.
The BChE activity was measured in plasma according to the Ellman's method.
The BChE-K homozygotes were significantly associated with lower BChE activity.
The Bcl-2 family protein , Mcl-1 is known to have anti-apoptotic functions , and depletion of Mcl-1 by cellular stresses favors the apoptotic process.
The BDI-II also predicted baseline memory.
The BDI-II total score was positively associated with RSA ( β = @number@ p = @number@ ) .
The BDNF Met-allele carriers showed a significantly smaller decline in set shifting during follow-up compared with the homozygous BDNF Val-allele carriers.
The beam is split by a lens into several microbeams , and super-pulse repetition is limited by the pulse width.
The bed is intended both for elderly and persons with a disability.
The Beers criteria of @number@ were used to evaluate PIMs.
The beginning of the search time frame was not restricted and the end of the search time frame was @date@ .
The beginning of the target sentence was indicated by the keyword \ "Stefan \ ".
The BEHAVE-AD and the NPI-NH had similar rates and showed a high convergent validity.
The behavioral analyses showed a positivity bias , that is , a preference for positive words , in recognition memory.
The behavioral deficits started at 6-8 months of age and were associated with a progressive increase in the accumulation of 3R Tau.
The behavioral results showed that reduced attentional resources for relational information during encoding equated YAs RM performance to that of OAs.
The behavioral symptoms are distressing to patients and their caregivers.
The Behaviour Rating Inventory of Executive Function ( BRIEF ) was completed by the mothers and a preschool teacher.
The Belgian law has addressed assisted suicide as an option in case of unbearable psychic suffering with no future prospective.
The Bem Sex Role Inventory ( BSRI ) is the most commonly used and validated gender role measurement tool across countries and age groups.
The beneficial and potential adverse effects are reviewed with a discussion on the current cardiovascular controversy.
The beneficial axis promotes adipogenesis , blocks the production of inflammatory cytokines , and lowers oxidative stress , thereby improving insulin sensitivity and secretion.
The beneficial effect of exercise on depressive symptoms is restricted to APOE-e4 non-carriers.
The beneficial effects of acetylcholinesterase inhibitors , however , are typically short-lived and accompanied by adverse effects.
The beneficial effects of fasting followed by vegetarian diet in rheumatoid arthritis are confirmed by randomized controlled trials.
The beneficial effects of resveratrol are believed to be associated with the activation of a longevity gene , SirT1.
The beneficial effects of WBV observed in previous studies of younger women may not occur to the same extent in elderly individuals.
The beneficial metabolic effect is translated to improvement in atherosclerosis , which is characterized by a decrease in carotid intima-media thickness.
The beneficial role of ROS in lifespan extension is consistent with the essential role of these molecules in cell signalling.
The benefit of complete surgical excision , adjuvant radiotherapy and endocrine treatment in preventing recurrence and invasive progression has been demonstrated in DCIS.
The benefit of neurosurgical intervention in the octogenarian population and the outcome is unclear.
The benefit of restoring an outer facial frame , periorbital frame , and perioral frame is elaborated.
The benefit of tele-homecare was measured by annual willingness to pay ( WTP ) for tele-homecare by a user and medical expenditures avoided.
The benefit of the physical activity intervention did not differ significantly based on hospital exposure.
The benefit on reaction time performance was evident for both age groups and persisted after cessation for 15-20 min.
The benefit-risk ratio of beta blockers and ACEI has to be carefully considered in the case of cardiopathy. double dagger.
The benefits and burdens of providing standard therapy to a vulnerable population are discussed.
The benefits and drawbacks of new technology and human factor considerations associated with increased general aviation automation will be debated.
The benefits and limitations of each therapy , and how and when to apply each in the setting of chronic distal dissection , are discussed.
The benefits and limitations of NMDAR antagonists that can diminish the excitatory neurotoxicity triggered by glutamate are also addressed in relation to AD.
The benefits clients expect from physiotherapy-led treatment include an improvement of gait , a better speed of motion and the decrease of fatigue and rigidity.
The benefits of activity varied by stage of disease.
The benefits of quercetin for exercise performance may have implications for athletes and extended to disease prevention.
The benefits of these animal-derived products are wound healing promotion , anti-inflammatory , antimicrobial activity , moisturizing effect , biocompatibility , and safety.
The benefits of this agent as a possible medication should be more thoroughly clinically tested.
The benefits seem to be equivalent between frail and nonfrail participants.
The benefits that improvements and dedication in nutrition and fitness approaches may offer at the molecular level are also discussed.
The benefit was particularly evident among the participants with a baseline SPPB score of ≥7 ( interaction P < .001 ) .
The bene ts of monotherapy with hydroquinone for melasma and retinoids for photodamaged skin is well established.
The bereaved spouses were also compared with a group of married contemporaries ( n = @number@ ) regarding subjective health and depressive symptoms.
The bereavement exclusion criterion in the DSM-IV should be reconsidered.
The BER expression pattern in Tg-ArcSwe mice thus reflects responses to oxidative stress in vulnerable brain structures.
The Berg Balance Scale ( BBS ) has been the main instrument used to evaluate balance impairment.
The Berlin Questionnaire and the Epworth Sleepiness Scale were used to screen individuals for OSAHS-related symptoms.
The best approach to pre-operative screening and decolonization programmes remains unclear.
The best characterized are laminopathies , depending on lamin A / C gene mutations and affecting tissues of mesenchymal origin.
The best characterized function of VHL protein is suppression of the α subunit of hypoxia inducible factor ( HIF ) .
The best characterized hTERT spliced variants encode for inactive proteins that possess specific deletions within the hTERT catalytic domains.
The best characterized oxylipins in relation to cardiovascular disease are derived from the ω-6 fatty acid arachidonic acid.
The best classifiers based on OARSI grade and score were T1- and T2-weighted image intensities , which yielded accuracies of @number@ and @number@ respectively.
The best described molecular link between alveolar epithelial dysfunction and myofibroblast activation and proliferation is the profibrotic cytokine transforming growth factor-β ( TGF-β ) .
The best discriminant using DXA variables was obtained with total femur aBMD ( AUC = @number@ p = @number@ ) .
The best discriminative distance between control and AD cases was found in the temporal pole / dentate gyrus rostrocaudal length in histological sections.
The best estimates of national seroprevalence were obtained by geographic regional weighting and corrections for selection and measurement bias.
The BESTest revealed that functional balance in fallers was worse than in non-fallers.
The best examples of positive outcome for both pain relief and functional improvement are total hip arthroplasty and total knee arthroplasty.
The best fit parameters in this case turn out to be related by a form of SM correlation.
The best fitted equations were then tested on a new sample of @number@ subjects ( @number@ males and @number@ females ) for validation purposes.
The best fitting growth curves were determined using statistical methods for linear mixed effect models.
The best-fitting model also indicated specific genetic influences on learning , which accounted for @percent@ of the overall variance.
The best markers include the clone CR3 / 43 , Iba1 , and CD68.
The best model was chosen with the adaptive lasso procedure.
The best @number@ Portuguese swimmers ( 12- to 18-year-olds ) for the main individual swimming pool events of both genders were considered.
The best of three attempts for PIF measured through the mouth , and five for each nostril for SNIP were recorded.
The best overall agreement was achieved at a distribution volume ratio of @number@
The best performing algorithm yielded an accuracy of @percent@ and an area under the curve ( AUC ) of @percent@.
The best performing anthropometric PE was then compared to published anthropometric PEs in an older ( age≥50 years ) cohort of @number@ people.
The best PLS-DA model produced a fall classification accuracy of AUC = @number@
The best-practice cohort life expectancy has increased from @number@ years in @number@ to @number@ years in @number@
The best predictors of long walking distance were ability to squat without limitations and low BMI ( @percent@ and @percent@ , respectively ) .
The best sensorial character was obtained in wines aged @number@ d on lees.
The best set of predictors was extracted from the baseline variables in one randomly selected half of the sample.
The best strategy to prevent lower GI complications has yet to be defined.
The best-studied class of short ncRNAs , microRNAs , mainly repress gene expression post-transcriptionally.
The best studied example of this process is A-to-I RNA editing.
The best surgical approach for internal fixation of displaced proximal humeral fractures is still being debated.
The best validated susceptibility variants for Parkinson's disease are located in the α-synuclein ( SNCA ) and microtubule-associated protein tau ( MAPT ) genes.
The between-group difference in overall survival ( OS ) was not significant , although this trial was not powered to detect such a difference.
The between-group difference in the R2-R1 of the elbow joint after the 6-week treatment was statistically significant.
The between-group statistical analysis indicated similar cortical thickness in the patients as in the healthy controls.
The beverages did not alter performance parameters during maximal exercise.
The beverages enhance the gene expression of antioxidant enzymes in peripheral blood mononuclear cells after exercise in young athletes.
The biases should not be taken lightly because they may pose serious obstacles to our understanding of the molecular basis of human diseases.
The bibliographies of articles identified through this search were searched manually for additional references of interest.
The bibliographies of extracted papers were also searched for relevant articles.
The bibliographies of qualifying studies were searched.
The bidirectional relation between MDD and chronic disease is now firmly established.
The biggest challenge in neuro-oncology is the treatment of glioblastoma , which exhibits poor prognosis and is increasing in incidence in an increasing aging population.
The biggest contributions were found for biomechanical and physical exposures , and job insecurity.
The biggest LI% is in the south provinces of China , whereas the biggest CI% is in the northwestern provinces of China.
The biggest PutwV was in the group of 30-60 years old.
The biggest risk factors for stroke , besides age , are results of the metabolic syndrome.
The bilateral pneumothorax was well controlled , and no recurrence has been observed.
The bilingual status includes early bilingual , late bilingual and monolingual.
The binary image is cleaned and thinned to a fiber skeleton representation of the image.
The binding activities of the immobilized CB1 / CB2 receptors were established using frontal affinity chromatographic techniques.
The binding constant was determined by UV-visible.
The binocular DVA was measured while walking on a treadmill at @number@ and @number@ m / s speeds.
The Binominal test was used for comparisons ( p < @number@ ) .
The bioactive food components have a potential preventive action on cancer.
The bioavailability of free lutein and PLGA-NP lutein in rats was assessed by determining plasma pharmacokinetics and deposition in selected tissues.
The biochemical basis of nrf-2 activation needs to be substantiated in human studies.
The biochemical composition , AGEs , and their age-related trends were determined from data reduction of the Raman spectra and compared for the two tissues.
The biochemical evaluation showed very high FSH serum levels in the presence of central hypogonadism.
The biochemical function of this enzymatic system is the metabolism of reactive dicarbonyl metabolites , glyoxal and methylglyoxal , to less reactive products.
The biochemical modulations by acupuncture in the brains of Alzheimer's models are correlated with the cognitive improvement.
The biochemical processes that link APTX deficiency to mitochondrial dysfunction have not been well elucidated.
The biochemical properties of the signal-induced multifunctional transcription factor II-I ( TFII-I ) indicate that it is involved in a variety of gene regulatory processes.
The bioengineered autograft exhibits significantly better survival in the hosting site.
The bioengineered hair follicles also autonomously connected with nerves and the arrector pili muscle at the permanent region and exhibited piloerection ability.
The bioengineered hair follicles properly connected to the host skin epithelium by intracutaneous transplantation and reproduced the stem cell niche and hair cycles.
The biofilm contains mucins , salivary glycoproteins with oligosaccharides side chains able to sequester water and endogenous bacteria surrounded by a glycocalyx.
The bio-identical progesterone may indirectly regulate bone remodeling and may also play a role in the development and maintenance of cartilage.
The biological activities of macrophage migration inhibitory factor ( MIF ) might be mediated through a classical receptormediated or non-classical endocytic pathway.
The biological age ( BA ) equation is a prediction model that utilizes an algorithm to combine various biological markers of ageing.
The biological age score equation was employed to compute the individual biological age scores for all subjects.
The biological aging process is commonly associated with increased risk of cardiovascular diseases.
The biological aspects of these models are contrasted and the types of research questions that may be addressed with these models are presented.
The biological clock , whose function deteriorates with increasing age , determines bodily circadian ( i.e. 24h ) rhythms , including that of cholesterol metabolism.
The biological consequences of cellular senescence and immortalization in aging and cancer are in conflict.
The biological diagnosis relies on the identification of excessive secretion of the metanephrines which are more sensitive and specific than those of catecholamines.
The biological , functional , clinical and evolutionary significance of this epigenetic drift , however , remains unclear.
The biological function of BTK in several B-cell lymphoid malignancies has led to the development of the oral BTK inhibitor ibrutinib.
The biological mechanisms of aging , and more specifically cellular senescence , are increasingly a subject of research.
The biological mechanisms responsible for the decline in skeletal muscle mass during aging remain unknown.
The biological mechanisms underlying cortical T1 reductions remain to be further elucidated.
The biological mechanisms underlying the increased AD risk in women remain largely undetermined.
The biological mechanisms underlying this age-related neuronal decline are not well understood.
The biological reason for this morphological change is unclear and still not fully understood.
The biological relevance of these endpoints for UVA-induced skin damage , however , is not known.
The biological role of pancreatic L-PHP is still not clear.
The biological roles of the proteasome activator REGγ are not completely understood.
The biological significance of such biased reduction of methionine sulfoxide has not been fully explored.
The biological significance of these regulatory circuits is discussed in this article.
The biologic mechanisms hypothesized to underlie frailty are explored , particularly in the musculoskeletal , endocrine , and immune systems.
The biologic response of hydroxyapatite needs to be fully understood for its use to be confidently recommended.
The biologic significance of atypical melanocytic proliferations within melanocytic matricomas is uncertain and requires further study of additional cases and long-term follow-up.
The biologic significance of polyploidization in senescent reversal , within the context of new ways to think of liver aging and liver diseases is considered.
The biomarker pairs detected MCI with sensitivity , specificity and overall accuracy similar to those obtained in the first study.
The biomarker results were compared among mild and moderate to severe AD as defined in the NIA-AA work group guidelines.
The biomarkers of brain injury neuron-specific enolase and S100β protein , age , and level of education were included in secondary multivariable logistic regression analyses.
The biomechanical load required to rupture the bone-tendon junction was determined.
The biomechanical mechanisms underlying sex-specific differences in age-related vertebral fracture rates are ill defined.
The biomechanical response of the human aorta varies with axial location , but little is known about the respective variation of residual strains.
The biomechanics literature contains many well-understood mechanisms behind typical fracture types that have important roles in treatment planning.
The biometric measurements were performed with the aid of the OcuScan® ( Alcon , USA ) .
The biopsies were taken immediately after implantation of the product and at day @number@
The biopsy specimens harvested during surgery were subjected to histologic evaluation , an immunohistochemical reaction with monoclonal anti-elastin antibodies , and the DAB chromatic reaction.
The bioreactor used in this study is a close-loop tubular reactor.
The birth cohort effect was evident in each category ( quartile ) reflecting the continuous decline in H. pylori acquisition.
The BI showed a similar trend to BBS.
The bi-tensor diffusion model was introduced to quantify the contribution of free water and eliminates its bias on estimations of tissue microstructure.
The bivalent vaccine has also been shown to be effective in reported trials.
The BIVA technique is a promising tool for the screening and monitoring of nutrition and hydration status in Alzheimer's disease.
The black sample displayed a similar pattern as the white sample , although a decrease was observed in cognitive function scores once BMI reached obesity.
The black South African population is witnessing a tremendous increase in the prevalence of cardiovascular disease , part of which might be explained through urbanization.
The black-white disparity in IADL independence narrowed poststroke.
The Bland-Altman plots revealed wide limits of agreement for all measures.
The Bland and Altman plots confirmed that %BF-Brozek reflects a better agreement with %BF-DXA.
The Bland and Altman plots confirmed that none of the three dynamometers reflects a good agreement with the Jamar Hydraulic.
The blinded clinical evaluation of photographs confirmed significant improvement in the intervention groups compared with the control.
The blockade of ETA receptor can increase the availability of ET-1 to the ETB receptor and can potentiate the neuroprotective effects of EPO.
The blocking of IGFBP4 / 7 also reduces apoptosis and promotes cell growth , suggesting that they may have a pleiotropic effect on MSC biology.
The block of RAGE completely prevents this effect.
The blocks were timed such that it was sometimes necessary for participants to adjust their speed in order to pass through the gap.
The blood-brain barrier ( BBB ) has many important functions in maintaining the brain's immune-privileged status.
The blood-brain barrier ( BBB ) plays critical roles in the maintenance of central nervous system ( CNS ) homeostasis.
The blood-brain barrier ( BBB ) represents the interface between the brain and other body tissues.
The blood-brain barrier ( BBB ) , which saves the brain from toxic substances , is formed by endothelial cells.
The blood-brain barrier is an interface between the circulation and brain.
The blood cellular fractions offer a viable alternative to current cerebrospinal fluid and neuroimaging modalities.
The blood pressure J-curve discussion has been ongoing for more than @number@ years , yet there are still questions in need of definitive answers.
The blood samples were collected within @number@ h before the embryo transfer and analyzed by six-color flow cytometry.
The blunt cannula may provide more comfortable and lower risk delivery of CaHA for nasolabial folds ( NLF ) correction.
The BMD of the thoracolumbar spine , upper , and lower extremities were measured using QCT and DXA , respectively.
The BMD was measured at the femoral neck.
The BMI and W / H ratio were calculated.
The BMI cut-off point of the NSI offers better sensitivity and specificity for men ( @percent@ and @percent@ respectively ) .
The BMI in early-onset patients was lower than that in the late-onset patients ( F = @number@ P = @number@ ) .
The BMI of the patients is significantly higher than the BMI of the athletes and untrained students.
The BMI × race / ethnicity interaction was also found to be significant.
The BMI range was @date@ @number@ kg / m ( @number@ ) .
The BM is well understood to play a key role in plasma cell homing and survival in mice.
The BMT + C group trained one-on-one , 3× / week for @number@ weeks on a balance obstacle course while completing cognitive tasks.
The BMT group trained one-on-one , 3× / wk for @number@ weeks on a balance obstacle course.
The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy.
The bodily experience of patients near end of life has been presented within sociological literature as largely undifferentiated.
The body composition was measured using dual-energy X-ray absorptiometry ( DXA ) and mobility was assessed by motor tests.
The body mass index , aldosterone-renin ratio and pulse wave velocity ( PWV ) were significantly higher in UCRH patients.
The body mass index of the patients was limited to @number@.0±2 kg / m2.
The body of evidence on older adults ' sexual health is beginning to grow.
The body of evidence relating to topical investigational agents is growing and involves controlled trials as well as individual cases.
The BOLD amplitude enhanced with increasing age , modulated by task conditions.
The bolus technique was performed in the right side , and serial puncture technique was done on the left side.
The bone is a preferred site for breast cancer metastasis and leads to pathological bone loss.
The bone loss is accompanied by microarchitectural deterioration resulting in reduced mechanical strength likely leading to fragility fractures.
The bone marrow ( BM ) plays a key role in the long-term maintenance of immunological memory.
The bone mineral densities in the femoral neck and lumbar spine improved after @number@ year , and were maintained at the 3-year follow-up.
The bone remodeling mechanism has sparked great interest among bone research societies.
The bone samples were μCT scanned and the 3D microstructure was quantified.
The bone-targeting calcitonin analogues were also tested in a separate cohort of male rats developing adjuvant-induced arthritis.
The boundaries of nuclear cores containing from @number@ to @number@ mg , in @number@ mg increments , were determined from the isoindicial shells.
The bovine serum albumin tannin assay also allows for the estimation of the anthocyanins content with the measurement of small and large polymeric pigments.
The bowhead whale ( Balaena mysticetus ) is estimated to live over @number@ years and is possibly the longest-living mammal.
The BPM method utilized for controlling SCM muscle may be a valuable alternative to control SCM muscle contraction when electromyography equipment is not available.
The BQG showing gait function increased in the gait speed ( m / s ; P = @number@ ) .
The brachial and cPP showed a small decline from the young group to the middle group and a greater rise after @number@ years old.
The brain activation during DTW was correlated with executive function.
The brain aging process is not uniform.
The brain and cord share the same cellular components , yet the latter is simpler in cytoarchitecture and connectivity.
The brain and eye share a common embryological origin and numerous similarities exist between the small vessels of the retina and brain.
The Brain Atrophy and Lesion Index may have use in quantifying the impact of dementia on brain structures.
The Brain Bank Committee of the Japanese Society of Neuropathology also allowed an e-mail inquiry with regard to possible resource supply.
The brain changes as we age and these changes are associated with functional deterioration and neurodegenerative disease.
The brain contains all that makes us human , but its complexity is the source of both inspiration and frailty.
The brain-derived neurotrophic factor ( BDNF ) plays an important role in activity-dependent synaptic plasticity , which underlies learning and memory.
The brain during healthy aging exhibits gradual deterioration of structure but maintains a high level of cognitive ability.
The brain functional connectome constitutes a unique fingerprint allowing identification of individuals among a pool of people.
The brain has a central role in the regulation of energy stability of the organism.
The brain has a high level of complexity and needs continuous oxygen supply.
The brain has long been known as a dimorphic organ and as a target of sex steroids.
The Brain Health Registry will help recruit subjects and monitor subject cognition.
The brain is a lipid-rich organ where docosahexaenoic acid ( DHA ) is enriched and where eicosapentaenoic acid ( EPA ) may have anti-inflammatory effects.
The brain is dynamic , with some areas developing faster and becoming more dominant until other areas catch up.
The brain is highly susceptible to oxidative stress , which increases during ageing and is considered a major contributor to neurodegeneration.
The brain is not idle during rest.
The brain is one of the most energy-demanding organs in the body.
The brain is studied by board certified neuropathologist.
The brain network is quantitatively described as a plane , rostrocaudally-oriented , and presenting Euclidean / real distances.
The brain processes involved in attending to relevant information while filtering out irrelevant information are still largely unknown.
The brain regions susceptible to hypometabolism are the hippocampus , entorhinal cortex and cognition-associated neocortical regions like parietal , temporal and frontal cortex.
The brain reserve hypothesis has been posited as being one important mediating factor for developing dementia , especially Alzheimer's disease ( AD ) .
The brains are sourced from a population-based autopsy service.
The brain's need of n-3 PUFAs is predominantly met by the blood delivery due to their limited synthesis in the brain.
The branching structures of neurons are a long-standing focus of neuroscience.
The Brazilian recombinant hepatitis B vaccine ( VrHB-IB ) is based on the expression of the recombinant antigen in Hansenula polymorpha yeast cells.
The Brazilian version of the Center for Epidemiologic Studies Depression Scale was used to screen for depressive symptoms.
The BRCA1 tumour suppressor has an important role in this process and is believed to channel the DSBs into the HR pathway.
The bread group had significantly larger regional gray and white matter volumes of several regions , including the right frontoparietal region.
The breadth of high antibody responses over time was more influenced by age than by the frequency of infection.
The briefs were presented to the Ghana Health Service in @number@
The British Geriatrics Society Fit for Frailty guideline is consensus best practice guidance for the management of frailty in community and outpatient settings.
The broad scale of affected cognitive domains suggests wide-spread network disturbances that not only involves , but also extends beyond the frontal lobe.
The broad spectrum of economic and cultural diversity in the U.S. population correlates with and affects the study of behavioral aspects of health.
The broad theme of this first paper is the mechanisms and biology of oxidative stress.
The broken clock is recovered by melatonin administration , that is accompanied by the normalization of the innate immunity and mitochondrial homeostasis.
The brow in men is usually more resistant to downward movement until they are in their fifties.
The BS and FA gene products co-operate in the repair of damaged DNA.
The BSRI and health indicator questions were completed by @number@ community-dwelling adults aged 65 + living in Aragon , Spain.
The BTM reference values determined in this study were also significantly different from the reference values given by the manufacturers of the reagents used.
The buccal , blood-1 , and blood-2 measurements generated heritability estimates of @percent@ , @percent@ and @percent@ , respectively.
The buccal branch was affected in @number@ percent.
The Bucharest Early Intervention Project is a unique randomized controlled trial of foster care placement compared with continued care in institutions.
The build in fail safe mechanisms of homeostasis , which prevent skewing toward disease , themselves contribute to aspects of aging.
The bulkier and longer tail of Edaglitazone exhibited additional hydrophobic interactions , explaining its stronger binding to PPARγ supported by binding affinity calculations.
The burden of cardiovascular events and of osteoporotic fracture is considerable for the health care system in term of costs and resources.
The burden of disease is greatest in the elderly.
The burden of geriatric conditions was significantly higher in the HIV-infected group compared with controls ( P < @number@ ) .
The burden of hip fractures in elderly population has been growing worldwide.
The burden of obesity is particularly relevant in old age , due to accumulating co-morbidities and changes in body composition.
The burden of ovary cancer in China will continue to be relative stable due to the aging population.
The burden of pleural diseases continues to rise and affects an increasingly complex and aging patient population.
The burden of pneumococcal disease can be reduced by effective vaccination programs , but the recommendations on pneumococcal vaccination in adults vary widely.
The burden of premature death and health loss from ESRD is well described.
The burden of providing informal care to a family member can lead to caregiver depression and potentially harmful caregiving behavior.
The burden of these diseases is considerable when taken with the annual @number@ million people worldwide who will suffer stroke.
The buried bumper syndrome is a rarely encountered but grave complication of percutaneous endoscopic gastrostomy.
The bursting force of the SMAS was @number@ N , with the average bursting pressure of @number@ PSI.
The C1-C2-C3 morphology of the ISCEV standard pattern onset VEP becomes apparent consistently after @number@ years to @number@ check stimulation.
The C-4 carbonyl group in the carabrane-type sesquiterpenoid @number@ and the C-9 ether linkage in the germacrane sesquiterpene @number@ were associated with the enhanced potency.
The Ca and P contents of the left coronary arteries in the 40s were significantly higher in men than in women.
The Ca and P contents tended to increase in the left coronary arteries of men with age , but the increases were not statistically significant.
The c-ABL non-receptor tyrosine kinase and the p53 tumor suppressor protein are pivotal modulators of cellular responses to DNA damage.
The Cache County Memory Study is a prospective study of persons initially aged @number@ and older in @number@
The Cache County Study on Memory in Aging is a longitudinal , population-based study of Alzheimer's disease ( AD ) and other dementias.
The Cag type IV secretion system delivers these proteins inside the epithelial cells.
The C-A haplotype was significantly different between LA group and the control group ( P = @number@ ) .
The CAIDE risk score replicated well with a C statistic of @number@ quite similar to the original CAIDE C statistic of @number@
The CAIDE score also predicted well within different race strata.
The CA-Klotho cell line was subjected to real-time PCR and showed positively changed expression of genes related to aging and cell survival.
The calcifications in the arteries were determined by CT imaging and the artery PET images were analyzed slice by slice.
The calculated specificity and sensitivity of the concurrent arm swing-stepping test was @number@ and @number@ % for hesitation and @number@ and @number@ % for incoordination.
The calculated TRP ( tubular reabsorption of phosphate ) was decreased and the FGF23 increased.
The calculation needs only the raw velocity and patient age.
The calculation of bias demonstrated no obvious trend for either overestimation or underestimation of age when all individuals were pooled together.
The calf circumference was measured at the point of greatest circumference.
The California Verbal Learning test ( CVLT-II ) was used to assess their episodic memory function.
The call bells were on average @number@ cm away from the bed.
The C allele was associated with lower triglycerides , and this association was modulated by fat intake.
The caloric deficit was ~2800 kcal per week for all groups.
The calorie restriction paradigm has provided one of the most widely used and most useful tools for investigating mechanisms of aging and longevity.
The CAM-based method missed chart-identified cases occurring during the night shift.
The Cambridge Neuropsychological Test Automated Battery ( CANTAB ) is a semiautomated computer interface for assessing cognitive function.
The Canadian health care system's delivery and policies are often based on a heterosexual nuclear family model.
The Canadian Health Measures Survey between @date@ and @date@ , documented the oral problems that elderly people experience.
The Canadian Study of Health and Aging was conducted in three waves over a 10-year period ( 1991-2002 ) .
The canal system appeared cleaner , clearer and more sharply defined than in the other age groups.
The cancer incidence rate is not constant within the human life span ( it exponentially increases with advancing age ) .
The cancer metabolism regulation related to O-linked β-N-acetylglucosame was described.
The Cancer Registry of Norway has registered data on patients with chronic lymphocytic leukemia since @number@
The cannabinoid CB1 receptor has gained much attention as a potential pharmacotherapeutic target in various neurodegenerative diseases including Alzheimer's disease ( AD ) .
The canonical function of TERT is the synthesis of telomeric DNA repeats , and the maintenance of telomere length.
The canonical function of TERT is the synthesis of telomeric DNA repeats and the maintenance of telomere length.
The canonical function of TERT is to prevent telomere erosion and thereby the development of replicative senescence and genetic instability.
The canonical senescence markers p16 , p53 , and p21 were up-regulated and coexisted with apoptosis in old-age human microaneurysms.
The capability of central nervous system ( CNS ) cells to regenerate is most limited , because their repair is inhibited by anti-apoptotic molecules.
The capability of spine DXA in identifying men with T-score ≤-2.5 is at its maximum around the fifth decade of life and it decreases later.
The capability of the retina to produce these trypsins was analyzed with polymerase chain reaction.
The capacity for recovery may be negatively impacted by advancing age but can be boosted by interventions such as diet restriction and exercise.
The capacity of CD4 ( + ) T cells to proliferate and secrete IL-2 cytokine was inversely associated with the level of KLRG1 expression.
The capacity of suppressing lymphocyte proliferation of the 13th passage MSC was enhanced , compared with the 5th passage.
The capacity to generate an efficient innate immune response is pivotal for survival.
The capacity to produce regulated variation is a phenotypic property , which is not described in the genome.
The capacity to self-identify goals and pursue actions toward goal achievement transcends age.
The capacity to walk independently is a central component of independent living.
The capillary bed was quantified by two parameters : capillary area ( CA ) and intercapillary distance ( ID ) in @number@ age groups.
The capillary bed , which is a space-filling network , is treated as a porous medium and modelled using a homogenized continuum approach.
The capsular specimens were probed with an AFM cantilever tip to produce force-indentation curves for each specimen.
The capsule elasticity of young humans ( < 45 years ) was not statistically different from that of the monkey and baboon.
The carcinogenic risks following radiation exposure rise with age among adults.
The cardiac axis in a structurally normal heart is influenced by a number of factors.
The cardiac blood supply-workload balance gradually improves from infancy to young adulthood.
The cardio-ankle vascular index ( CAVI ) is a reliable indicator of arterial stiffness and early arteriosclerosis.
The cardiometabolic risk attenuated , but the augmented kynurenine pathway activity could increase the oncogenesis risk.
The cardioprotective effects of resveratrol are associated with its preconditioning-like action potentiated by its adaptive response.
The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved.
The cardiovascular effects of escitalopram were examined in a large group of participants in double-blind , randomized , placebo-controlled studies.
The Cardiovascular Health Study ( CHS ) and Health , Aging , and Body Composition ( ABC ) study were used for validation.
The cardiovascular risk-benefit profile of T therapy remains largely evasive in view of a lack of well-designed and adequately powered randomized clinical trials.
The cardiovascular risk profiles were compared in patients aged > 90 years with and without CAD after cardiac catheterization.
The cardiovascular variables play a crucial role in the evaluation of biological aging.
The care for older people with PWS requires a lifespan approach that recognizes the presence , progression , and consequences of specific morbidity.
The caregiver burden was measured with the short version of the Zarit Burden Interview ( ZBI ) .
The caregiver-provider encounter is examined , and challenges faced by service providers in addressing sexuality are considered.
The caregivers of stroke patients are faced with various stressors that can threaten different aspects of their health , especially their mental health.
The caregivers of the patients were given a questionnaire concerning the awareness of and attitudes toward VCI.
The caregivers ' religiosity was salient to how they viewed and coped with their caregiver role.
The caregivers should be aware of this and pay a lot of attention to these two groups of non-verbal expressions.
The caregiving role undertaken by these women does not appear to be sustainable under their current circumstances.
The care of disabled individuals subjected to litigation should be coordinated by an attorney or registered nurse.
The care of multimorbid patients is , therefore , heavily reliant upon guidelines developed mostly for single diseases.
The care of the older person with hip fracture is complicated by their comorbid condition , limited physiological reserve , cognitive impairment and frailty.
The care of these previously rare conditions is a new challenge for caregivers in haemophilia centres.
The care processes used for the elderly are known to differ between the care providers in Sweden.
The Carer Support Needs Assessment Tool provided a formal structure to facilitate discussions with family caregivers to enable needs to be addressed.
The care should include keeping people with dementia involved in meaningful activities which decrease or eliminate behavioral symptoms of dementia.
The CareWell in Hospital questionnaire has good content validity , internal consistency , and test-retest reliability and warrants further research to explore responsiveness.
The carotenoids are a group of red , orange , or yellow pigmented polyisoprenoid hydrocarbons synthesized by prokaryotes and higher plants.
The cartilage clock could be reset by temperature signals , while the circadian period was temperature compensated.
The cartilaginous precursors of the distal clavicle and acromion conformed to the final shape of these structures.
The CAR was significantly lower in male patients compared to male controls and female patients.
The case-control design is often used to test associations between the case-control status and genetic variants.
The case fatality rate increased with increasing age , from @percent@ for those aged 17-54 years to @percent@ for those aged ≥75 years.
The case histories ( @number@ @number@ and @number@ ) of @number@ patients were studied.
The cases occurred in three men and four women aged between @number@ and @number@ years , with a mean of @number@ years.
The case studies presented here are then placed in the context of the literature regarding EB and weight change.
The case study is the method of analysis that we have recommended.
The cases were visually classified into predefined dementia patterns by three experts.
The CASE was then used with @number@ primary caregivers.
The catalogue of somatic mutations from a cancer genome bears the signatures of the mutational processes that have been operative.
The catalytic activity of MHY336 on the topoisomerase II enzyme was the same as that of the etoposide.
The catecholaldehyde hypothesis also leads to testable experimental therapeutic ideas.
The categorical data were compared among the four groups.
The categorical scores and transition analysis ages were subjected to multinomial logistic regression and decision tree analysis to derive accurate age interval estimates.
The categories function well , and responses to all items in these assessments are not biased by patients ' characteristics.
The category-free net reclassification improvement from SRCF was calculated at 15-year follow-up on CVD and all-cause mortality.
The cathepsin B , B & L and H activity increased over the rigor period.
The cathepsin K inhibitor odanacatib has recently been shown to decrease vertebral , non-vertebral , and hip fracture rates and is nearing approval.
The cationic components of liposomes can induce inflammatory responses.
The CAT polymorphism was not associated with brain outcomes in this cohort.
The caudal blocks were performed during ultrasonographic observation of the spread of local anesthetic ( LA ) in the epidural space.
The causality of these associations is debated.
The causality , preventability and severity of each ADR-related admission were assessed.
The causality , preventability and severity of each adverse drug reaction-related repeat admission within the 12-month follow-up were assessed.
The causal pathway often involves a concatenation of factors or events , some of which can be prevented or controlled.
The causative link between ambient wood particle constituents and observed adverse health effects is currently lacking.
The cause and mechanism of development of Alzheimer ' s disease ( AD ) remain unexplained.
The cause and mechanisms driving these distinct forms of bone loss , however , are complex and controversial.
The cause could be a GIST bleeding.
The cause for the accumulation and retention of molecules in the sub-RPE space , however , remains an enigma.
The cause of ALS is not known and it is not known yet why it affects some people and not others.
The cause of Alzheimer's disease ( AD ) is still unknown.
The cause of Alzheimer's is still not clear.
The cause of death was known in @number@ patients.
The cause of FUO was not found for @number@ patients.
The cause of mild to moderate dementia remained uncertain in @percent@ of the patients.
The cause of neuropathy may be levodopa-induced impairment of vitamin B12 metabolism , suggesting levodopa-naïve subjects should be unaffected.
The cause of the muscle wasting in these patients is not fully understood , and no predictive biomarker exists to identify these patients early on.
The cause of this decrease is probably related to patient aging coupled with bone erosion and / or deltoid impairment over time.
The causes and outcomes of AKI in children , middle-aged , and older patients are different.
The causes and spectrum of kidney disease among these patients is extensive , including HIV-related and HIV unrelated causes.
The causes of aging remain unknown , probably being related to a multifactorial process.
The causes of slowing down may be found on any stage of information processing.
The causes of such hampered FC are not understood.
The causes of the latter were not found.
The causes underlying this limited regenerative potential are multifactorial , but one critical aspect is neuroinflammation.
The causes were burn injury , twisting injury , and crush injury in @number@ cases , respectively.
The CBE-OUT is composed of @number@ items that can be recorded when present in the evaluated environment.
The CBE-SR is a four-scale instrument with good psychometric properties that measures the person-environment interaction.
The CBFV was measured using transcranial Doppler ultrasound , simultaneously with oxyhaemoglobin ( O2Hb ) using near-infrared spectroscopy and beat-to-beat BP measurements using Finapres.
The CBMN assay was conducted on cultured isolated lymphocytes stained with Giemsa.
The CC and thalami were manually segmented for each subject , and @number@ texture parameters were computed for each of these structures.
The CCFM was subsequently incorporated into NSHAP , Wave @number@ ( n = @number@ ) .
The CC genotype strongly bound to AP-2α , and the TT genotype showed less binding affinity to AP-2α.
The CCHS surveyed @number@ adults , providing a representative sample of the Canadian population.
The CCI score was inversely correlated with the levels of melatonin ( p = 0.03 ) .
The CCM lesions also exhibit damaged neuronal architecture , the likely cause of neurologic defects , such as ataxia and seizure.
The CCO activity , the amount of protein and the mRNA expression increased in the 3rd week and decreased afterwards in rats.
The CCSs for predicting stent revascularization were elucidated.
The CD33 single-nucleotide polymorphism ( SNP ) rs3865444 has been associated with the risk of Alzheimer's disease ( AD ) .
The CD34 + hematopoetic stem cell has shown significant promise in addressing myocardial ischemia by promoting angiogenesis that helps preserve the functionality of ischemic myocardium.
The CD36 scavenger receptor binds several ligands and mediates ligand uptake and ligand-dependent signal transduction and gene expression , events that may involve CD36 internalization.
The Cdc5L ( cell division cycle 5-like ) complex is a spliceosomal subcomplex that also plays a role in DNA repair.
The CD concentrations in the buttock skin samples were similar in both populations.
The cdk inhibitor and tumor suppressor p16INK4A is consistently upregulated in cervical carcinoma cells for reasons that are poorly understood.
The cDNA sequence encoding human sRAGE was optimized for RNA structure , stability , and codon usages in CHO cells.
The CDR functions as a consequence of system's thermodynamically determined intrinsic tendency to acquire new states of inner equilibrium and equilibrium against the environment.
The CD-RISC had acceptable reliability and a conceptually interpretable structure.
The CE and SA are feasible techniques to detect alteration in autonomic control of heart rate in the old group.
The C. elegans models developed severe locomotor defects associated with the aggregation of TDP-43 in neurons.
The cell activity was detected with MTT assay.
The cell adhesion was determined by flow cytometry and the cell shape was analyzed by scanning electron microscopy.
The cell-autonomous antimicrobial functions of autophagy have been established in the macrophage.
The cell-based approaches are focused on applying multipotent mesenchymal stem cells ( MSCs ) mostly harvested from bone marrow.
The cell-based assay showed that these two chemicals inhibited oxidative stress-induced neurotoxicity caused by over-expression of a PD-specific LRRK2 mutant , G2019S.
The cell cycle and chronological aging networks of proteins in budding yeast were reconstructed.
The cell cycle arrest and apoptosis in a dose-dependent manner was measured by flow cytometric and fluorescent microscopy analyses.
The cell delivery route stands as a key translational item that warrants careful consideration in facilitating the success of stem cell therapy in the clinic.
The cell is known to be the most basic unit of life.
The cell proliferation index , cell number index , expression of caspases and apoptosis-associated proteins and cell morphology were measured.
The cell proliferation rates of NPCs at passage @number@ in-vitro in monolayer culture and in 3-D alginate microsphere culture were detected.
The cells could be subcultured for @number@ passages.
The cells evenly covered the surface and displayed easily visualized single cell outlines.
The cells exhibited high proliferative capacity and differentiated toward cells of mesenchymal lineages with high efficiency.
The cells isolated from the tissues were characterized for osteoblastic , adipogenic , chondrogenic , and tenogenic differentiation in vitro and in vivo.
The cells showed the aging morphological feature.
The cells were differentiated into cardiomyocytes to assess phenotypes.
The cells were divided into the activated group and the negative control group.
The cells were serially cultured until they achieved the state of permanent growth arrest.
The cells were serially passaged and maximal lifespan evaluated.
The cells were shammed or irradiated with @number@ J / cm ( @number@ ) of UVA irradiation and treated with @number@ μg / mL astragaloside.
The cells were stimulated with hGH , IGF-I , hGH + IGF-I , and TGF-β1.
The cell that receives the inclusion body has decreased proliferation and increased differentiation compared with its sister cell without Htt.
The cellular and molecular changes exhibited by the aging gut cells also vary.
The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood , and current therapies are limited.
The cellular cohesion also increases with age , a result of the altered intercellular lipid structure.
The cellular consequences and metabolism of oxidatively damaged DNA can be quite complex with a number of DNA metabolic proteins and pathways involved.
The cellular content of kinase-1 and hexokinase @number@ was reduced consistent with diminished PI3K-AKT signaling and glucose metabolism.
The cellular content of the integral membrane protein glycophorin A , however , decreases with storage time in the more dense RBC fractions.
The cellular level of BLM is strongly dependent upon FANCJ , and BLM is degraded by a proteasome-mediated pathway when FANCJ is depleted.
The cellular line from a patient with diagnosis of \ "adenomyosis \ " had a lot of cells with changes in karyotype's structure.
The cellular line obtained from donor with adenomyosis showed signs destabilization of he genome , typical for cell transformation.
The cellular machinery leading to MP shedding involves the loss of the plasma membrane asymmetry and phosphatidylserine externalization with an increase in cytosolic calcium concentrations.
The cellular mechanisms underlying psychological stress are poorly understood.
The cellular nuclear-factor-kB ( NF-kB ) protein level was also reduced , confirming its role in the induction of SASP.
The cellular prion protein ( PrP ( C ) ) is an ubiquitously expressed glycoprotein that is most abundant in the central nervous system.
The cellular roles of topoisomerase IIβ are very less understood compared to its counterpart topoisomerase IIα.
The cellular transition from normal to malignant state is linked to deregulated gene expression.
The cement and the interaction of the cement and aging did not significantly affect the shear bond strength to zirconia.
The cement choice was not revealed as a determining factor after aging conditions , as long as composite cement was used.
The cement containing amorphous calcium phosphate ( Aegis ) did not bond to zirconia surfaces.
The cements containing the borate glass with @number@ mol % TiO2 had the highest initial compressive strength , ranging between @number@ and @number@ MPa.
The CEM predicts that , in the presence of filial values and certain background variables , caregiving demands are appraised as challenges instead of stressors.
The centenarian rate ( CR ) in @number@ was computed for Japan's @number@ prefectures , whose geography and climate vary greatly.
The centenarians received follow-up phone calls.
The Center for Epidemiological Studies Depression Scale was used to identify depressive symptoms ( threshold = ≥16 ) at the baseline visit.
The Center for Epidemiologic Studies Depression Scale-10 Korean edition was used as the dependent variable.
The Center for Epidemiologic Studies Depression Scale was used to assess depressive symptoms.
The Center for Epidemiologic Studies Depression scale was used to measure the extent of depressive symptoms.
The center of pressure area , mean velocity , and mean frequency in the anteroposterior and mediolateral directions were measured.
The Centers for Medicare and Medicaid Services Virtual Research Data Center allowed for rapid outcomes ascertainment.
The centiles of AMH distribution were estimated with the CG-LMS method.
The central atlantoaxial joint may be closely related to the mechanisms for protecting the spinal cord by restriction of the atlantoaxial movement.
The central auditory system has to perceptually segregate and group the acoustic input into sequences of distinct auditory objects.
The central circadian clock located in the suprachiasmatic nucleus of the hypothalamus is like other brain regions subject to age-associated changes.
The central female hypogonadism is a model of premature aging.
The central importance of epigenetics to the aging process is increasingly being recognized.
The central nervous system is the main target.
The central organizing concept that emerged from these data were managing complexity.
The central radiopaque positioning marker and the fine adjustment wheel allow for accurate positioning within degenerated bioprostheses.
The central role of AMPK in regulating cellular ATP regeneration , makes this enzyme as a central control point in energy homeostasis.
The central role of SIRT1 in multiple metabolic and age-related pathways has pushed SIRT1 to the forefront to discover small-molecule activators.
The Centre for Epidemiological Studies Depression Scale ( CES-D ) was administered at baseline and at follow-up @number@ years later.
The centre , home and no visit respondents differed in demographic characteristics , behavioural factors , physical functioning and health.
The centre-of-pressure displacement rates were similar to the control floor for the SmartCell floor condition.
The centre-only technique was an accurate predictor of values based on centre and peripheral measures , with @percent@ limits of agreement of @number@ OD units.
The centro-medial , cortical , and lateral nuclei were also atrophic in patients.
The CERAD-BRSD , soliciting reports of the fewest specific symptoms , detected the fewest psychotic symptoms.
The cerebellar mass was related to the body length ( R = @number@ for men and R = @number@ for women ) .
The cerebellum plays important roles in motor coordination and learning.
The cerebellum was a consistent outlier compared to all other regions , and showed over @number@ @number@ differentially methylated regions ( DMRs ) .
The cerebral substratum of age-related cognitive decline was evaluated in an elderly-cohort followed for @number@ years ( n = 306 ) .
The cerebrospinal fluid pressure ( CSFP ) may thus influence the choroidal venous blood pressure.
The cerebrovascular burden also was assessed in the younger patients with RVO.
The certainty of this conclusion is reduced by the variation across calculational methods.
The cervical paraspinous exhibited shorter latencies compared with the other muscles ( 2-143ms ) .
The cervical spine physiological age can be determined by summing up the scores obtained for each parameter.
The cervicomedullary angle significantly increased from flexion to extension posture , however , no significant differences were observed in every posture among the groups.
The CES-D is widely used for the assessment of depressive symptoms in the adult population.
The CES-D was assessed in both samples.
The CFA provided evidence of adequate overall model fit for a previously proposed 6-factor model.
The CFAQ1 scores indicated a low level of knowledge about ageing.
The cfPWV-age relationship was found to have a steeper increase in ESRD patients.
The cfPWV and PPA at baseline were assessed with an arterial tonometer.
The CFS may be used to triage resources to mitigate adverse outcomes in this population.
The CGA is allow to elaborate a personalized treatment plan in geriatric oncology.
The CGA is universally accepted as the most appropriate instrument to analitically evaluate the age related problems of elderly patients.
The CGA items are predictive of severe toxicity , however it is not clearly established which are the best performers and the best cut-offs points.
The CGA questionnaire used with these patients included the Chinese translation of the Gero-Oncology Health and Quality of Life Assessment tool.
The CGAs are evaluated in terms of psychometric properties and content comprehensiveness.
The CG continued their usual daily lives.
The CG underwent equivalent face-to-face training sessions using music therapy.
The chalcone also suppressed the expression of RANKL by the tumor cells.
The challenge for developing α1AT deficiency therapeutics is to understand the PN pathways involved in folding and export.
The challenge in finding reproducible loci of ischemic stroke susceptibility may be in part related to the etiologic heterogeneity in clinically defined stroke subtypes.
The challenge in high-income countries is to maintain access to care whilst dealing with trends in technology and aging.
The challenge is identifying the issues that have the greatest impact on the population so potential interventions can be prioritised.
The challenge is open for new submissions via the web-based framework : @url@
The challenge is to develop processing tools that effectively and reliably quantify subcortical small vessel disease in the context of brain tissue compartments.
The challenge is to enhance healthy ageing and to reduce the financial and social burdens associated with chronic ill health in later life.
The challenge now is to develop personalized supplements comprised of specific phytochemicals for each clinical situation.
The challenge now is to understand the senescence response well enough to harness its benefits while suppressing its drawbacks.
The challenge of an aging population is the occurrence of multiple diseases , complicated by geriatric syndromes , in the same person.
The challenge of comorbidity and the potential offered by new systems approaches for introducing these biomarkers into the clinical decision process will be discussed.
The challenge of developing comprehensive programs for the geriatric population requires changes in the care models and care pathways.
The challenge of global population aging has been brought into sharper focus by the financial crisis of @number@
The challenge of obtaining opinions which are not influenced by an individual's own circumstances is not new.
The challenge of the next future will be to develop biomarkers useful to identify the individuals who react abnormally to COX inhibition.
The challenge remains to causally link the molecular and cellular changes of aging with age-related changes in lung physiology and disease susceptibility.
The challenges and opportunities in this area of research and development are reviewed , covering the most up-to-date initiatives , trends , and topics.
The challenges of geriatric care demand prompt attention by proposing strategies for improvement in several key areas.
The challenges surrounding dementia are large and growing but are only part of broader social and health concerns.
The challenge to this objective is to combat the origin of the loss of physical function through treatment of chronic disease conditions.
The chance-corrected inter-rater reliability ( expert versus non-expert ) measure κ , based on binary outcome ( aMCI / not-aMCI ) , was estimated.
The CH and CRF were measured with the Ocular Response Analyzer.
The change from a mainly vegetarian fare to meat consumption went along with brain growth and increased insulin resistance to improve brain's glucose supply.
The change from baseline in the mean score was significant at each time point , including the final visit ( Weeks 20-21 ) .
The change from baseline in the MMSE score was @number@ in the solanezumab group and @number@ in the placebo group.
The change , however , was not statistically significant ( p < 0.098 ) .
The change in ACD was greater at the peripheral region than at the central region.
The change in baPWV during the study period showed a significant negative correlation with the change in L-BMD.
The change in dermal thickness from baseline to postintervention was significant ( P < @number@ Wilcoxon signed rank test ) .
The change in epigenetic status correlates with altered expression of TERT and genes near to TERT , indicating a change in chromatin.
The change in global cognition was not statistically significant ( paired t ( @number@ ) = @number@ p = @number@ ) .
The change in health functioning ( phase 1-3 ) score was examined with repeated measures analyses.
The change in hearing in noise testing and AZBio testing between pre and postimplantation was evaluated in each group.
The change in IOP between the @number@ examinations and the factors that were significantly associated with the change in IOP were investigated.
The change in MSNA between baseline and handgrip , for both frequency and incidence , increased with increasing handgrip intensity for both groups.
The change in muscle elasticity with exercise is higher in younger children.
The change in perceived fatigue rating was normalized to energy expenditure during walking to determine perceived fatigability.
The change in perceived fatigue was measured after a fast-pace 400meter walk test.
The change in scores between the control and intervention groups were compared using a two-way analysis of variance.
The change in the intestinal microbiota also influences the change in obesity and regresses the liver steatosis.
The change in the patients with low muscle mass was not significant.
The change in the physical composition including sarcopenia and sarcopenic obesity is likely attributable to the development of insulin resistance observed in the elderly.
The change in the ratio of OGT to OGA gene expressions correlated negatively with the change in muscle CSA.
The change in the Short Form-12 Physical Component Summary and Mental Component Summary scores did not differ significantly between the two groups.
The change point did not differ by sex , education level , or APOE ε4 genotype.
The change provides additional time for processing claims before the applicant ages out of the foster care system.
The change rate was @percent@.
The changes are consistent with expected behavior related to myelination and asynchrony of fiber development.
The changes are more distinct in females.
The changes associated with age were not differentially affected by sex or colonic region.
The changes between the estimates for the FI-OutRef quartiles in the univariate- and the multiple analyses were negligible.
The changes in cortical thickness with aging were obvious in the posterior side and trabecular bone on the medial condyle.
The changes in ED were compared between the two groups after three months of treatment.
The changes in fitness , hippocampal perfusion and volume were positively related to changes in recognition memory and early recall for complex spatial objects.
The changes in force signal's regularity presented a strong dependence on time-scales , which significantly interacted with age and condition.
The changes in glycosylation were performed by GalNAc-α-O-benzyl or sialidase treatment.
The changes in head control during narrow-base walking may be an attempt to simplify the interpretation of the vestibular signal and increase otolith sensitivity.
The changes in levels of ALP correlated well with the changes in BAP levels before and after bisphosphonate therapy.
The changes in number of MSK deaths between @number@ and @number@ were decomposed using two counterfactual scenarios.
The changes in respiratory function and symptoms over the study period were probably due to aging.
The changes in superficial layer and middle layer were more evident than deep layer.
The changes in the somatosensory system in aging and peripheral neuropathies are similar.
The changes observed in stressed subject may accumulate during repeated episodes of stress forming a picture typical of the aging brain.
The changes of mRNA and protein expressions of TH and GAP43 played a vital role in the process of maintaining the atrial fibrillation.
The changes of several metabolic and mitochondrial transcripts correlated significantly with changes in mitochondrial volume density.
The changes of these senescence associated markers suggested that HFS , but not HAS , could ameliorate replicative senescence of hAMSC in vitro.
The changes over time and the variability of the prospective indicators are smaller than those that are observed in the conventional ones.
The changes that accumulate in the vasculature with age , however , are highly variable.
The changes that some of the permanent fillers undergo during years of residence in human tissue have not been included in this discussion.
The changes that the skeletal muscle undergoes aging sarcopenia , alteration of fiber type distribution and also intimate metabolic transformations.
The changes were generally greater during the first observation period , and there were no significant gender difference.
The changes were more pronounced when GH was injected.
The change was not significant in NH C ( @number@ vs @number@ vs @number@ respectively ; H = 3.94 , ns ) .
The changing brain may lead to abrupt behavioural change with attendant risks , but such a brain is flexible and can respond quickly and imaginatively.
The changing frequency composition of the resting state EEG reflects maturation of brain function.
The channel was weakly cation-selective and showed several subconductance states.
The chaperone ability of α-crystallin for acetylated γD-crystallin was lower than that for the nonacetylated protein.
The chapter also reviews music interventions used for persons with neurodegenerative diseases.
The characteristic masses lost from the modified prenylated peptides distinguished the types of prenylation.
The characteristic of LV twist-displacement loop was like the configuration of @number@
The characteristics of CPLs were compared between the increase ( i.e. , size increase during subsequent follow-up ) and no-increase groups.
The characteristics of foot morphology were measured using a 3D foot scanner.
The characteristics of microglia-like cells were analysed by flow cytometry and functional assay.
The characteristics of people most likely to be at nutritional risk provide evidence for targeted screening and assessment.
The characteristics of the activity experience seem to determine the perceived fitness changes.
The characteristics of the cohort , including the initial IOP distribution , are based on data of @number@ patients.
The characteristics of the facilities had a significant influence on the proportion of in-hospital deaths among the nursing home decedents.
The characteristics of the nutritional status of women were established on the basis of anthropometric measurements.
The characteristics of these fractures are different from pelvic ring disruptions in adults.
The characteristics of underlying cardiovascular disease and MRI findings were compared between the younger patients with RVO and age-matched controls.
The characterization of gene expression profiles associated with interleukin-6 levels might suggest important molecular events underlying its regulation.
The characterization of mutational processes that generate sequence diversity in the human genome is of paramount importance both to medical genetics and to evolutionary studies.
The characterization of the genetic and environmental contributions to daily DHEAS concentrations is thus important for understanding the genetics of health and aging.
The charged FOS were digested with a sialidase and compared with free oligosaccharides from transferrin for structural decoding.
The Charlson comorbidity index was calculated using ICD-10 codes.
The chart also includes a measure of uncertainty in this estimate.
The chart-based method missed delirium in individuals that the CAM identified who were lacking features of psychomotor agitation or inappropriate behavior.
The chart is clinically interpretable as it plots an estimate of the failure rate for a \ "standard \ " patient.
The CHD cases were ascertained using an annual follow-up questionnaire and validated by an End Point Committee through a review of the medical records.
The checklist content was validated by consulting experts in the field.
The cheeses were then analyzed for the presence of Listeria monocytogenes , Salmonella , Escherichia coli O157 : H7 , Staphylococcus aureus , and Campylobacter.
The chemical potentialities of metabolites far exceed metabolic requirements.
The chemoattractive properties of the biomaterials were analyzed @number@ days after inoculation.
The chemosensory abilities of @number@ subjects , aged from @number@ to @number@ years , were evaluated.
The chemotactic capacity , phagocytic ability , and oxidative burst activity of circulating leukocytes were determined with flow cytometry kits.
The chemotaxis , phagocytosis , natural killer activity and lymphoproliferation in neutrophils and lymphocytes of peripheral blood were analyzed.
The chemotherapy efficiency was observed after at @number@ cycles of intra-arterial chemotherapy.
The chemotherapy group failed to improve at @number@ month after treatment but improved during the last two follow-up assessments.
The chemotherapy usage declined from @number@ % in @number@ to @number@ % in @number@ of the cohort.
The Chen group now identified 15-oxospiramilactone as a chemical inhibitor of the mammalian deubiquitylase USP30 , acting on Mfn1 and Mfn2.
The chest wall defect was reconstructed with a polypropylene ( Marlex ) mesh sheet followed by a left-side transverse rectus abdominis myocutaneous flap.
The CHH disease phenotype has some overlap with dyskeratosis congenita , a well-known \ "telomere disorder. \ "
The Chicago group had @number@ subjects with falls and @number@ deaths.
The child also presented scleroderma plaques on the abdomen.
The childhood estimates were robust , but the estimate for BMI at @number@ years was attenuated by adjustment for BMI at @number@ to @number@ years.
The childhood personal-history characteristics studied were known predictors of age-related disease and mortality , and were measured prospectively during childhood.
The children and adolescents examined here represent normal growth and development for an underrepresented south Asian population.
The children of a multiple sclerosis ( MS ) patient filed a guardian ad litem case to be brought against the patient.
The children sat unsupported for @number@ s while their posture and sway were quantified using stereophotogrammetry.
The children's mothers combed the kids prior to the start of the test in order to confirm that they were all lice-infested.
The children were not aware that hyperthermia could adversely affect the brain of MS patients.
The children with ADHD made more errors than children on the control group.
The children with CP presented the highest EMG and level of co-activation ( p < .05 ) .
The Chilean older population has a high life-expectancy , but the prevalence of functional dependence is also high.
The Chinese Cantonese MoCA had a high internal consistency with a Cronbach's alpha of @number@
The Chinese Health Literacy Scale for Low Salt Consumption - Hong Kong population ( CHLSalt-HK ) was also assessed.
The Chinese patients had the lowest 5-year survival compared to Malay and Indian patients.
The Chinese society is rapidly aging.
The Chinese survey measured important environmental aspects in developing regions that were missing in the WHO AFC framework.
The Chinese TFI had excellent criterion validity with the AUCs regarding physical phenotype and frailty index of @number@ and @number@ respectively.
The chi-squared test was used to compare the distribution of failure modes ( p < @number@ ) .
The Chi-square test and the linear Chi-square test were performed for bivariate analysis , as well as logistic regression for multivariate analysis.
The chi-square test , multiple regression analyses and multinomial logistic regression analyses were performed using SAS @number@
The chi-square test was used to compare the proportions and the level of significance was @percent@.
The chitosan-based functional food also has been reviewed.
The Cho / Cr decreased rapidly at 0-5 years , then continued to decline , and was stable after @number@ years of age.
The choice between treatment modalities depends on physician and patient preferences.
The choice of acupoints and the frequency of EA have to be taken into account to achieve a positive treatment effect.
The choice of end criteria will have an impact on the number of the participants as well as the VO2max outcome.
The choice of going deep or wide depends on the goal of the ascertainment.
The choice of incidence rates on which to build the estimates may be critical.
The choice of initial insulin therapy can be made based on blood glucose profiles.
The choice of measures will take into account the potential resources available for outcome and process evaluation.
The choice of task contrast consistently shows a greater impact than the age cohort , for ( P , R ) metrics and activation overlap.
The choice of testosterone assay is important in clinical decision making.
The choice of the events is reduced to the claim of being observable.
The choice of treatment should be based not only on the fracture type but also on the local and general comorbidity of the patient.
The cholinergic system is well-established as important to cognition.
The chondrocyte-like cells in transgenic discs expressed higher levels of connective tissue growth factor ( CTGF ) than were expressed in WT counterparts.
The chondrogenic potential is defective in PG-MSCs , although both PG and LMNA transduced MSCs , have an increase in hypertrophy markers during chondrogenic differentiation.
The chondro-osseous interphases became progressively more lobulated and notched in the distal acromion and clavicle respectively.
The chorioretinal junction comprises the retinal pigment epithelium , Bruch's membrane ( BM ) , and adjacent choroidal capillaries.
The choroidal tissues from C57BL / 6J and 129S6 / SvEvTac mice and Sprague Dawley rats were isolated and incubated in Matrigel.
The choroidal vascular diameter was significantly greater in adults than in children ( P < @number@ ) .
The choroid plexus contains fenestrated capillaries surrounded by tightly connected choroid plexus epithelial cells that form the blood-cerebrospinal fluid barrier.
The choroid plexus epithelium is a cuboidal cell monolayer , which produces the majority of the cerebrospinal fluid.
The Christian faith offers the possibility of retaining and recovering the sense of personhood and connection with God and others.
The chromatin regulatory factor SIRT6 plays pivotal roles in metabolism , tumor suppression , and aging biology.
The chromosomal aberrations frequently found in MM are ' hyperdiploid ' or ' non-hyperdiploid ' and immunoglobulin gene ( Ig ) translocation of chromosomes.
The chromosomal passenger complex ( CPC ) plays a pivotal role in the regulation of cell division.
The Chronic Disease Self-management Program ( CDSMP ) focuses on increasing self-efficacy for managing chronic disease.
The chronic expression of damaged proteins during disease can have devastating consequences on protein homeostasis ( proteostasis ) , resulting in disruption ofnumerous biological processes.
The chronic inflammation that ensues has been named " inflammaging. "
The chronic inflammatory state at old age may contribute to the pathophysiology of or reflect chronic conditions resulting in loss of physical and mental functioning.
The chronological age of an individual animal predicts many of its biological characteristics , and these in turn influence population-level ecological processes.
The ciliary body becomes collagenized , there are choroidal vascular changes , and Bruch's membrane thickens.
The cingulo-opercular effect increased for participants with the best overall performance.
The cingulum showed no correlation.
The ciPSCs expressed critical pluripotency markers and showed evidence of silencing the viral vectors and normal karyotypes.
The circadian clock choreographs fundamental biological rhythms.
The circadian clock directs many aspects of metabolism , to separate in time opposing metabolic pathways and optimize metabolic efficiency.
The circadian clock entrains to diurnal environmental changes by using light and food intake as external time cues.
The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells.
The circadian rhythm is a fundamental physiological process present in all organisms that regulates biological processes ranging from gene expression to sleep behavior.
The circadian timing system controls daily rhythms of physiology and behavior , and disruption of clock function can trigger stressful life events.
The circadian variation of heart function and heart sounds in patients with and without heart failure ( HF ) is poorly understood.
The circulating levels of humanin decline with age in mice and humans.
The circulating sex steroids were associated with better muscle quality while the muscle concentrations reflected the amount of infiltrated fat within muscle tissue.
The circulatory diseases seem to mostly affect the presence of long-lived individuals and a prominent effect of altitude and population density also emerges.
The circumference of the descending portion increased significantly as the severity of aortic atherosclerosis increased ( p for trend < @number@ ) .
The CISD2 gene , which is an evolutionarily conserved novel gene , encodes a transmembrane protein primarily associated with the mitochondrial outer membrane.
The cistrome was integrated with transcription data to obtain a global view of LXR action in keratinocyte biology.
The citizens ' own health and social situation are included as explanatory variables.
The citrullination might also be occurring during aging process in healthy populations.
The claimed beneficial effects of the Mediterranean diet include prevention of several age-related dysfunctions including neurodegenerative diseases and Alzheimer-like pathology.
The claims-based diagnosis of obesity underestimates the true prevalence in the older Medicare population with a low sensitivity ( @percent@ ) .
The Claims-based Frailty Indicator might be used in research with large datasets for confounding adjustment or risk prediction.
The classical estrogen receptors ( ERα and ERβ ) are ligand-activated transcription factors that confer estrogen sensitivity upon many genes.
The classical Framingham risk equation provides a method for predicting cardiovascular risk , but it does not include the kidney function indexes.
The classical functions of p53 protein are those related to its role on DNA damage , cell growth arrest , senescence and apoptosis.
The classical neurotransmitter noradrenaline ( NA ) has critical roles in modulating behaviors including those involved in sleep , anxiety , and depression.
The classification accuracies of quantitative MRI parameters and corresponding weighted image intensities were evaluated.
The classification accuracy obtained by this approach is @percent@ , which is an increase of at least @percent@ from the conventional full-spectrum methods.
The classification accuracy of the resulting scoring system - the six-item CDT - was examined.
The classification accuracy was @number@ and @number@ for adipose tissue , @number@ and @number@ for soft tissue , and @number@ and @number@ for bone.
The classification method allowed indentifying the most important muscles in each wrinkle pattern.
The classification of hallucinations into subtypes may not be meaningful , and most visual and auditory hallucinations were not associated with negative affect.
The classification of the three sleep stages are achieved by a multi-class support vector machine using the one-versus-rest scheme.
The classification of UAB can provide a reasonable basis for the future research.
The classification performances of the used algorithms were compared.
The classification rate was determined by a planar discriminant analysis.
The classification tree determined age thresholds for changing behaviours but also found dates when profiles changed within the same age-sex group.
The classification was validated by three plastic surgeons.
The classified blocks are then used to design an efficient graph-cut based segmentation algorithm.
The classifier integrating all @number@ types of surface measures significantly improved classification performance compared with classification based on single measures.
The clathrin assembly protein , CALM , promotes the assembly of clathrin-coated vesicles.
The clearest correlations could be detected between plasma SP-A vs. age , pack years and FEV1 / FVC.
The Clearfil Esthetic Cement showed the lowest microtensile bond strength and a significant reduction after @number@ years of storage in artificial saliva.
The clepsydra of foods may help choose foods associated with healthy benefit while avoiding foods associated with harm , including cancer.
The CLHLS sample consisted of @number@ individuals aged @number@ years and over in @number@
The clients in the intervention group routinely received occupational therapy , whereas clients in the control group received assistance from a home help for bathing.
The clinical and developmental implications from these findings are discussed.
The clinical and epidemiological studies discussed in this section give an update on the interplay between late onset hypogonadism ( LOH ) and CVD.
The clinical and histological characteristics are analogous to hereditary ataxias in humans.
The clinical and paraclinical data , etiological diagnosis , treatment and follow-up modalities were analyzed retrospectively.
The clinical and psychiatric assessments were done by an expert team including psychiatrists , through an informant.
The Clinical and Translational Science Awards ( CTSA ) program represents a significant public investment.
The clinical aspects of NASH , as part of the metabolic syndrome in the aging population , have been presented.
The clinical benefits of coronary revascularization must be cautiously weighed against the risk of reducing the protective support derived from coronary collaterals.
The clinical benefits of such screening remain uncertain and merits investigation.
The clinical case studies are a good educational tool to promote home care medicine in pharmacies and university pharmaceutical colleges.
The clinical characteristics and cognitive performance of the @number@ groups did not differ at baseline.
The clinical characteristics on admission were analyzed , and the patients were followed for @number@ months.
The clinical characteristics , procedural data , and clinical outcomes were compared in patients with versus without CAVB.
The clinical characteristics were compared between the elderly and younger patients.
The clinical classification of hereditary sequence variants identified in disease-related genes directly affects clinical management of patients and their relatives.
The clinical conditions on admission represent the most important factor for the treatment results.
The clinical consequences of endothelial dysfunction and CVD will also be reviewed.
The clinical consequences of immunosenescence include increased susceptibility to infection , malignancy and autoimmunity , decreased response to vaccination , and impaired wound healing.
The clinical course and management of liver disease in the elderly may differ in several aspects from those of younger adults.
The clinical course is slow with chronic worsening.
The clinical course of CLL presents with an impressive heterogeneity.
The clinical course of MCI is heterogeneous , with a significant number of cases progressing to dementia or reverting back to normal.
The clinical course was evaluated , including need for drug therapy / surgery or drug therapy intensification.
The Clinical Dementia Rating score was used as an alternate grouping variable in three of the studies.
The clinical diagnosis of osteoporosis has evolved over the past @number@ years to emphasize the relationship between compromised bone strength and fracture susceptibility.
The clinical effect of microglia in patients with Alzheimer's disease ( AD ) is poorly defined.
The clinical effect of microglia in patients with Parkinson's disease ( PD ) is poorly defined.
The clinical efficacy of MA was confirmed on artificially tanned human skin.
The clinical end points were recurrent ICH , ischemic vascular events , and vascular death ( fatal ICH or ischemic vascular events ) .
The clinical endpoint was an epidermal temperature of @number@ °C. Two blinded reviewers assessed photographs taken at baseline and @number@ days post-procedure.
The clinical evaluations included detailed testing of cognitive function from which previously established composite measures of global cognition and specific cognitive functions were derived.
The clinical examination included the measurement of muscle strength using Lovett test.
The clinical examination will determine the depth of the lesions to treat and will take into consideration counter-indications and specific limits to each patient.
The clinical experience in elderly patients is still in its infancy , but available data indicate that these approaches are feasible and promising.
The clinical expression of adult onset TD is protean , with varied symptoms and signs often overlapping with those of aging and several chronic conditions.
The clinical expression of intrinsic aging include smooth , dry , and thinned skin with accentuated expression lines.
The clinical factors that may accelerate the cardiac aging process include visceral obesity , diabetes mellitus , dyslipidemia , and hypertension.
The clinical features of accelerated aging and the molecular finding were consistent with the diagnosis of Hutchinson-Gilford progeria syndrome ( HGPS ) .
The clinical features of Parkinson's disease are primarily motor deficits , while the patients of Alzheimer's disease present with dementia and cognitive impairment.
The clinical features of TD depend on the age of onset.
The clinical features shown by our patient were typical of KS with the exception of chorioretinal degeneration which is a rare manifestation.
The clinical features , treatment monitoring and molecular genetic mechanism of CAH are reviewed.
The clinical features were compared among five groups of patients , divided according to onset age.
The clinical heterogeneity of Parkinson's disease ( PD ) may point at the existence of subtypes.
The clinical impact and management of low volume metastasis in high-risk patients should be further clarify.
The clinical impact includes a year-on-year increase in skin cancer incidence , and topical sunscreens alone provide an inadequate measure to combat overexposure to UVR.
The clinical impact of testicular aging implies androgen production decrease and diseases associated with aging.
The clinical implications of enlarged early cortical components of somatosensory evoked potentials in benign adult familial myoclonus epilepsy remain unknown.
The clinical implications of FHD lesions in this specific population are yet to be clarified.
The clinical implications of the observed changes in V˙O2max and muscle strength will be important to explore in future studies.
The clinical implications of these findings , in relation to efficacy and tolerability , deserve further investigation.
The clinical implications of these findings require further investigation.
The clinical implications of urinary periostin activities in patients with type @number@ diabetes have not been evaluated.
The clinical information was collected ; and the nasopharyngeal aspiration fluid and serum samples were sent for multi-pathogen detection.
The clinical interpretation of change on the ADAS-cog or MMSE differs depending on age.
The clinical judgment of the general practitioner is finally retained for determining the eventual presence of frailty.
The clinical management of fragility fracture is simple but complex at the same time.
The clinical manifestations in older-onset IBD are distinct , and patients tend to have less of a disease trajectory.
The clinical outcome of the infection may involve a combination of bacterial factors , host factors and environmental factors.
The clinical outcome of this material will be apparent from the results of prospective , randomised clinical studies.
The clinical outcomes of this pharmacotherapy adherence approach were the secondary objective of the study.
The clinical outcome variables were retention loss , marginal discoloration , detectable margins , and a clinical index comprising the three parameters by weighing them.
The clinical phenotype is extremely variable and its severity does not correlate with the genotype or with recorded ammonium / ornithine plasma levels.
The clinical phenotype was characterized by early onset dementia in @number@ affected subjects over @number@ generations.
The clinical phenotype was typical for DS and his intellectual disability was mild in severity.
The clinical presentation and evolution of AF can be highly variable.
The clinical presentation is often atypical and the presence of unexplained falls is particularly frequent.
The clinical profiles , treatment methods , and outcomes were investigated.
The clinical , radiological and pathological characteristics of those patients were summarized.
The clinical ramifications of our findings emphasise the importance of an accurate evaluation and attention to unemployment status during the care of these patients.
The clinical relevance of such a pathway for bone pathology in diabetes should be further investigated.
The clinical relevance of these findings was supported by the positive significant correlations of BMI-related BPs with left ventricular mass and atrial diameter.
The clinical risk factors for POPF after DP using a triple-row stapler were identified based on univariate and multivariate analyses.
The clinical significance and long-term progression of subclinical RBD needs to be further explored , given the prevalence and its possible relation to RBD.
The clinical significance is that a home-based walking program may be one approach to increase endogenous antioxidant capacity.
The clinical significance of this is uncertain and warrants further investigation.
The clinical significance remains unresolved , a few studies showing Baastrup disease as a cause of back pain.
The clinical spectrum of TTD varies widely from patients with only brittle , fragile hair to patients with the most severe neuroectodermal symptoms.
The clinical staging systems by Rai and Binet have been the backbone of clinical management for several decades.
The clinical success rate was @percent@ after the 7-year follow-up.
The clinical syndromes were characterized by nonspecific and psychiatric symptoms at disease onset and progressed to predominant motor signs.
The Clinical Test of Sensory Interaction and Balance and posturography integrated with virtual reality ( Balance Rehabilitation Unit ) were used.
The clinical trial register of the United States National Institutes of Health Differences was searched for all current clinical trials on breast cancer treatment.
The clinical use of the ADC might be associated with less useless diagnosis procedures , without significant increase in rate of diagnosis failure.
The clinical use of these parameters can be help to design and target appropriate public health interventions.
The clinical utility of the NPI also needs to be further explored.
The clinical utility of these biomarkers and flow parameters at the bedside are yet to be elucidated.
The Clinical Working Group from SLANH was put in charge of finding a consensus definition of a confirmed clinical case of CKDnT.
The clinicopathologic significance of BLM in sporadic breast cancers is unknown.
The CL intensities from the PCR products could be enhanced approximately 10-fold using FITC-labeled primers as compared with those using nonlabeled primers.
The clock controls these cellular functions both locally in cells of peripheral tissues and at the organismal level via extracellular signaling.
The clock drawing tasks were blindly scored with Freedman's method.
The Clock Drawing Test ( CDT ) is a cognitive screening tool used in clinical and research settings.
The Clock-in-the-Box ( CIB ) is a rapidly administered cognitive screening measure which has been previously validated with cognitive screening and neuropsychological assessments.
The clonidine clearance rate was two-fold that measured in patients not on ECMO.
The cloning of p53 cDNA was done in the beginning of eighties and soon after that the whole p53 gene was cloned.
The close linkage of these two has led people to believe that aging , like age , is immutable.
The close link between cardiac function and brain health has numerous clinical and public health implications.
The close monitoring of patients with HF improves adherence , reduces mortality and improves survival.
The closest AUDIT-C was not statistically significantly associated with rs2066702.
The closest AUDIT-C was obtained a median of @number@ years after the VACS-BC blood draw.
The closing of hospitals has exacerbated challenges for older adults in accessing healthcare , especially those living in economically underserved settings.
The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation , with a particular emphasis on neurodegenerative disorders.
The clots were lysed by tPA and / or transcranial Doppler ultrasound sonication for @number@ h.
The CLU gene is one of the prime genetic candidates associated with Alzheimers disease.
The cluster analysis identified six distinct groups that hold very different expectations.
The cluster file from this experiment is available at www.chargeconsortium.com / main / exomechip.
The cluster groupings were used to predict working memory performance.
The clusters we have identified in this study can help tailor the development and deployment of eHealth intervention to specific segments of the older population.
The CMAP scan has potential value as a follow-up tool in monitoring disease progression , recovery or aging of the peripheral nerves.
The CMJ performance is significantly reduced only in S group ( @number@ m , p < 0.001 ) .
The c-Myc and hTERT protein and mRNA levels were significantly higher in local recurrent gastric cancer samples than in primary gastric cancer samples.
The CNCR analysis is supported by demographic data and by the Death Records Database.
The CNS differs from other organs due to several peculiarities that affect local immune surveillance.
The CNS dysfunction may induce several human pathological conditions associated with both cognitive impairment and a variable degree of neuroinflammation.
The CNS plays a pivotal role in the regulation of energy and glucose homeostasis.
The CNS symptoms included drowsiness , lethargy , confusion , seizures and coma.
The coating of Aβ on outer segments may also have an impact upon visual function with age.
The cochlear implant recipients also completed three speech perception tests , the CUNY , HINT sentences , and the CNC test.
The cochlear nucleus ( CN ) is populated by morphologically diverse types of neurons with discrete physiological and neurochemical properties.
The Cochrane risk-of-bias assessment criteria and the Newcastle-Ottawa Scale were used to assess the quality of the studies.
The Cochran-Mantel-Haenszel test was used to identify variables associated with frailty.
The Cockcroft-Gault ( CG ) and MDRD equations and the serum cystatin C concentration produced the highest correlations with the gold standard.
The co-cultured HDFs exhibited increased expression of SA-β-GAL.
The CoDe system increases the probability of classifying deaths more accurately in people living with HIV / AIDS.
The coefficient of nonlinear correlation ( r ) between Vmca and EtCO ( @number@ ) was @number@ in girls vs @number@ in boys.
The co-efficient of repeatability ( CoR ) was calculated for each bleaching technique.
The coefficient of variation ( CoV ) of stride time and walking speed were recorded under usual condition and while counting backwards.
The coefficient of variation of blood glucose ranged from @percent@ to @percent@ in the glucagon-like peptide-1 group and from @percent@ to @percent@ in saline group.
The coefficients of quadratic , linear , polynomial and power-law approximations were calculated using the least-squares fitting procedure.
The coenzyme bioavailability may be significantly affected by these reactions , with ensuing major impact on energy metabolism , cell survival , and aging.
The co-factor CHIP ( C-terminus of HSP70-inteacting protein , STUB1 ) ubiquitinates chaperone substrates and directs proteins to the cellular degradation systems.
The cognitive changes on the ADAScog were not different among the groups.
The cognitive changes that occur with ageing are usually referred to as ' age-related cognitive decline'.
The cognitive control and fluency scores did not differ between the groups or correlate significantly with the disease markers.
The cognitive deficits correlated with neuroimaging findings in concussed participants.
The cognitive domains included processing speed , memory , language , visuospatial , and executive functions.
The Cognitive Drug Research test battery was used to assess the effect on their cognitive abilities.
The cognitive effects of other agents targeting the co-agonist site of NMDA receptors are also discussed.
The cognitive function declined with age increasing.
The cognitive function of illiterate elderly persons was assessed using Chinese revised Mini Mental State Examination ( MMSE-r ) in @number@ and @number@
The cognitive functions of delayed responders were assessed by home visits.
The cognitive function substudy began in @number@
The Cognitive Function Trial evaluated cognitive function in all TTrials participants.
The cognitive function was assessed by using the Mini-Mental State Examination ( MMSE ) and the Montreal Cognitive Assessment ( MoCA ) .
The cognitive function was measured preoperatively , one week and six months postoperatively by the mini-mental state test ( MMSE ) .
The cognitive impairment in people with DS is virtually universal but varies considerably with respect to expressivity and severity.
The cognitive implications of these common markers are not well understood.
The cognitive neuroscience of aging is a growing and stimulating research area.
The cognitive reserve hypothesis postulates that individuals with higher IQ are able to better tolerate age-related increase in brain pathologies.
The cognitive reserve hypothesis suggests that appropriate cognitive stimulation could maintain or improve cognitive performance.
The cognitive stimulation indices were only significant in univariate analysis.
The cognitive subtypes have imprecise boundaries and have limited ecological validity.
The cognitive tasks perceived to be equally difficult were selected for the second phase.
The cognitive test battery included @number@ tests assessing memory and executive function ; a global cognitive score summarized performances across these tests.
The cognitive tests were added into six different cognitive domains.
The cognitive training group displayed improved cognitive speed @number@ months after intervention.
The CO group showed no difference between materials and had highest μTBS.
The cohort comprised men aged ≥40 yr who had undergone @number@ or more serial transrectal ultrasonographies.
The cohort comprised @number@ DLB cases and @number@ controls.
The cohort comprised @number@ elderly subjects who had at least one prescription filled during the study year.
The cohort consisted of @number@ Health and Retirement Study participants who were aged @number@ or older and dementia-free at baseline.
The cohort disparity trends for both disabilities showed a decline with each successive cohort except for ADL disparity among women.
The cohort effect tended to show a slight oscillation from @number@ to @number@
The cohort included @number@ patients / cycles : @number@ smokers , @number@ non-smokers.
The cohort of patients included @number@ patients who underwent surgical procedures in the department of urology between @date@ and @date@ .
The cohort ranged from @number@ to @number@ years old , with @number@ ( @percent@ ) females.
The Cohorts for Heart and Aging Research in Genomic Epidemiology-AF ( CHARGE-AF ) risk prediction model variables served as our benchmark.
The cohorts were defined by the preoperative use of BBs and BB type ( non-CYP2D6 BBs , CYP2D6 BBs , or no BBs ) .
The cohorts were followed up from adulthood or old age , taking into account possible confounders and mediating paths.
The cohort was analyzed to compare longevity among all players , and for players stratified by ethnicity , with the general U.S. population.
The cohort was established in 1971-75 with follow-up examinations being conducted approximately every @number@ years.
The cohort was followed for a mean of @number@ years for CVD and all-cause mortality.
The cohort was followed up for mortality till @date@ .
The cohort was followed up for total mortality until @date@ , by means of record linkage with the National Causes of Death Register.
The cohort was followed up to @number@ y ( until @number@ ) to detect incident dementia cases.
The cohort will be assessed every two years , with in-depth assessments being repeated.
The cold-induced change in skin perfusion was not related to age or BMI in either group.
The collaboration between geriatrician and oncologist remains essential to elaborate an appropriate therapeutic strategy and limit the situations of over- and under-treatment.
The collaboration of multiple community partners in program implementation and delivery is essential.
The collagen AGE autofluorescence in patient vein graft material increased with patient age.
The collagen and hyaluronic acid ( HA ) synthesis was then measured using the collagen kit and ELISA , respectively.
The collagen mass also contained fine elastin , fibroblasts , lymphocytes , occasional granulomas , and vessels.
The collagen-rich connective tissue is produced , organized , and maintained by dermal fibroblasts.
The collateral circulation is not a permanent set of structures , but undergoes dynamic changes with important consequences for cardioprotection.
The collected data included patient characteristics ( demographics , comorbidities , and medication exposure ) and repeat vertebral augmentation.
The collected data were entered into a checklist and subjected to statistical analyses.
The collection and analysis of data in semi-structured interviews was based on the model of signs , meanings and actions.
The collection of information for this review was limited to the most recently available human data.
The collective academic output of the BBDP is now described as the Arizona Study of Aging and Neurodegenerative Disorders ( AZSAND ) .
The collective antioxidant properties and transcriptional effect of this extract suggest potential antiaging properties which could be utilized in cosmetic and nutraceutical formulations.
The collective data suggest that telmisartan is a promising drug for controlling hypertension and reducing vascular risk in high-risk elderly patients with new-onset diabetes.
The collective transcriptional effects of these extracts suggest interesting antiaging properties which could be utilized in nutraceutical antiaging formulations.
The colocalization analysis of CD8 and CD3 , however , suggested the suppressed activity of these effector cells in tumor microenvironment.
The colonization and cell number of Bifidobacterium species in human intestine vary with ageing.
The colony forming efficiency of PDLSC for three experimental groups was determined.
The color analysis was performed @number@ h after cementation of the samples and after @number@ months of storage in relative humidity by means of spectrophotometry.
The color change ΔE ab , Δb and Δa exhibited by Arabic coffee , in Turkish coffee and Nescafe except Δa .
The color differences ( deltaE ab ) between before and after aging were calculated by CIE Lab color-difference formula.
The color difference stabilized within @number@ days.
The colorimetric analysis was performed using Commission Internationale de l'Éclairage standards.
The colorimetric coordinates of the IOLs were calculated by measuring their transmission spectra using a microspectroscopy technique.
The Color Trails Test ( CTT ) was developed as a culturally fair analog of the Trail Making Test.
The coma root mean square also was higher ( P < @number@ ) in the Crystalens group than in the young group.
The combination effect of the methanolic extract with doxorubicin was also investigated by determination of a combination index.
The combination of 8-Br-cAMP and VPA synergistically increases the efficiency to @number@.5-fold.
The combination of activated CD8 ( + ) T cells with any of the cytokines provided the best fits in young and aged animals.
The combination of age-related increases in obesity and inflammation can lead to chronic disease , decreased strength , and physical disability.
The combination of aging and composition had a significant effect on all dynamic properties ( P < @number@ ) .
The combination of any code plus laboratory abnormality increased PPV ( @percent@ ; 95%CI , 47%-79% ) .
The combination of Aβ and tau imaging studies would likely help elucidate the relationship or interplay between the two pathologic hallmarks of the disease.
The combination of BMI + WC and BMI + WHtR using current cut-off points may provide an improved measure of hypertension risk.
The combination of both imaging modalities can lead to better discrimination between early-stage AD and normal aging.
The combination of creatine supplementation and resistance training could be an effective intervention to improve aging musculoskeletal health.
The combination of creatine supplementation and resistance training may further lead to greater physiological benefits.
The combination of HF and COPD presents many therapeutic challenges including beta-blockers ( BBs ) and beta-agonists.
The combination of infarcts and leukoaraiosis carried the worst prognosis , presumably reflecting small vessel disease.
The combination of Massive epidural scarring and spinal deformity represents the ultimate challenge for the spinal deformity surgeon.
The combination of MLN0128 and TSA induces apoptosis in most breast cancer cell lines tested , but not in the non-malignant MCF-10A mammary epithelial cells.
The combination of modern interventional and preventive medicine has led to an epidemic of ageing.
The combination of reduced vision , hearing , memory and mobility contributes to isolation and depression.
The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.
The combination of the obesity epidemic and an aging population presents growing challenges for the healthcare system.
The combination of these attributes simultaneously promotes high specialization and high integration within a modular small-world architecture.
The combination of these effects accelerated neurodegeneration in PS cDKO ; WtTau mice.
The combination of these techniques is described in the second section.
The combination of two or more of aforementioned comorbidities further increases the risk of relapsing BPPV , worsened by the presence of osteoporosis.
The combination of various modifications and their accumulation with age not only affects function , but leads to crosslinking and protein aggregation.
The combined approach is considered the best treatment choice.
The combined effect of systemic inflammation and excess clotting on tissue function leads to end-organ disease.
The combined effects of porosity and AGEs resulted in an @percent@ reduction in propagation toughness.
The combined effect was stronger than either of the individual effects , and both gene variables explained significant proportions of variance in BOLD signal change.
The combined influence of CSF biomarkers and hypertension ( HTN ) on the gray matter ( GM ) is also not well described.
The combined method had high predictive validity for all clinical outcomes.
The combined population-attributable risk was 60·3% ( @percent@ CI 43·7-69·3 ) .
The combined results thus suggest that both CMV-dependent and CMV-independent immunosenescence occurs.
The combined therapy did not impair epidermal barrier function.
The combined training group displayed improved cognitive speed both immediately and three months after intervention.
The comet assay was used to evaluate the DNA damage , strand breaks and formamidopyrimidine DNA glycosylase ( FPG ) -sensitive sites.
The commentary outlines these key challenges , as well as the proposed solution of each , with concrete examples from our working plan.
The comments made by older adults and their caregivers in focus groups provided the narrative for this paper.
The commercially available artificial tears tested lack both the antioxidant content and UV absorbing characteristics of natural tears.
The common and specific involvement of brain networks in clinical variants of Alzheimer's disease ( AD ) is not well understood.
The common belief that signs of atherosclerosis and cardiovascular disease ( CVD ) are clinically relevant only during adult and elderly age is gradually changing.
The common cause of Hyponatremia was SIADH ( @number@ ) followed by drugs of which diuretics was the major contributor.
The ' common cause ' theory of ageing proposes that declines are shared across multiple , seemingly-disparate functions , including both physical and intellectual abilities.
The common clinical presentations of frailty ( falls , delirium , sudden immobility ) can also be used to indicate the possible presence of frailty.
The common co-morbid conditions were Hypertension ( @percent@ ) and diabetes mellitus ( @percent@ ) .
The common extensor , common flexor , quadriceps , patellar and Achilles tendons and plantar fascia insertions were evaluated with gray-scale and power Doppler ultrasound.
The commonly cited explanation is the \ "grandmother hypothesis \ " , which applies only to higher , social mammals.
The commonly perceived aging changes in the lower eyelid are a natural consequence of the anatomic attachments and age-related changes in the periorbital tissues.
The common model of demyelination-induced increase in radial diffusivity cannot directly explain these results.
The common nature of the trait suggests the presence of many genetic factors that individually may have modest effects.
The common neural network and behavior suggests that healthy aged subjects thought about their future prospects in the past.
The common problems are bedtime resistance , delayed sleep onset and frequent night waking.
The common variant Val393Ala in COQ2 does not appear to be associated with MSA in ethnic Chinese.
The communication was wholly electronic.
The communities may provide social support , contribute to self-preservation , and serve as an opportunity for self-discovery and growth.
The Community Integration Questionnaire ( CIQ ) is the most widely used community integration measurement tool used in research for people with TBI.
The community interviews provided demographic , health , and ADL information.
The community wellbeing index ( CWI ) is a new measure of the individual's level of satisfaction with the local place of residence.
The comorbidity of other psychiatric disorders makes diagnosis difficult and has negative effects on both treatment and the prognosis of ICDs.
The comorbidity score did not affect functional impairment.
The compact design of the simulator allows for the side-by-side arrangement of the stimulator units such that they impinge upon adjacent fingers.
The comparative utility of @number@ screening strategies ( biomarkers vs risk scores ) in identifying prevalent stage B HF is unknown.
The comparison between the two groups showed that the BMD of the WBV group had increased significantly ( P = 0.016 ) .
The comparison groups were the composite without adhesive and a 2-step etch-and-rinse AS ( Prime & Bond NT ) without etching of enamel and dentin.
The comparison of four samples in each condition further limited the possibility of false positives and provided various new , age- and strain-specific targets.
The comparison of sleep-deprived individuals with other groups with known difficulties in these linguistic skills might suggest that different groups exhibit common difficulties.
The comparison of the %BF-Siri and %BF-Brozek mean values also revealed significant differences ( p < @number@ ) .
The comparison of women who underwent bilateral oophorectomy with referent women provided evidence for a sizeable neuroprotective effect of estrogen before age @number@ years.
The comparisons of the repeatability of the velocity index between the left and right leg revealed the difference only in @number@ years old children.
The COMP has noted discordance between the prevalence of certain haematological malignancies at the time of Orphan Designation and at the time of Marketing Authorisation.
The complementary perspective is the prevention of frailty , which has physical , cognitive , social and psychological dimensions.
The complementation at the other studied loci : HM loci , telomere and sub-telomere does not occur.
The complete data from @number@ males and @number@ females aged ≥67 years were retrieved.
The complete dataset has been made publicly available as a comprehensive resource for future studies.
The complex contains the splicing factor hPrp19 , also known as SNEV or hPso4 , which is involved in cellular life-span regulation and proteasomal breakdown.
The complex etiology of aging is a challenge to the researchers.
The complex interaction between biological ageing and blood pressure elevation on the vasculature is highlighted.
The complex interaction between immune senescence and chronic illness provides an ideal landscape for translational research with the potential to greatly affect human health.
The complex interactions among these @number@ factors and the potential impact of exercise on cognition remain to be systematically studied.
The complex intervention consists of training at the GP practice with an interactive 2-day workshop to provide a patient's education programme.
The complexity is further increased when taking the step from model systems of aging to human aging.
The complexity of central breathing disturbances during sleep has become increasingly obvious.
The complexity of controlling the trunk in the mediolateral direction was suggested by different strategies used for trunk control in different conditions.
The complexity of HR dynamics was assessed using multiscale entropy analysis.
The complexity of multicellular organisms requires both an increase in genetic information and fine tuning in regulation of gene expression.
The complexity of the hearing process is reflected by its extensive genetic heterogeneity , with probably many causative genes remaining to be identified.
The complex macromolecular structure of chromatin regulates all nuclear processes requiring access to the DNA sequence.
The complex pathological consequences of genome instability are insufficiently explained by cell-autonomous DNA damage responses ( DDR ) alone.
The complex patterns of the expression of sirtuins in relation to tissue damage should be taken into account when searching for therapies interacting with sirtuins.
The compliance chamber volume greatly affected the dynamics of the RTD function , while the effects of mixing and flow were small to non-significant.
The compliance of large elastic arteries in the cardiothoracic circulation declines , whereas sympathetic nervous system activity increases markedly with advancing age in adult humans.
The complicated nature of various neuropathic features manifested early in neurodegenerative diseases suggests the involvement of a system-wide transcriptional regulation and epigenetic control.
The complication rate was higher in elderly as compared with younger patients.
The complication rate was @number@ ( @percent@ ) out of @number@ young patients and @number@ ( @percent@ ) out of @number@ elderly patients.
The complications after filler injection can occur at any time after the procedure , early and delayed , and they range from minor to severe.
The complications for secondary rhytidectomy included one hematoma and one hypertrophic postauricular scar.
The component scores of the SPPB and vSPPB were also moderately correlated ( all p values < .01 ) .
The components of our intervention could be easily adapted to the belongings of other professions.
The composite in-hospital MACCE rates did not differ statistically between both groups ( @number@ vs. @percent@ ; p = @number@ ) .
The Composite International Diagnostic Interview evaluated the presence of a 12-month history of anxiety and depressive disorders.
The composite score provided an overall score for the battery , ranging from @number@ to @number@ with higher scores representing better function.
The composite scores on memory , information-processing speed , and executive function were derived from a cognitive test battery.
The compositional profiles of tannins in the fruits vary depending on the cultivars as well as ripening stages.
The COM position in the elderly group during the backward COP shift was also significantly lower than that in the young group.
The composition of a red blood cell population was determined by the distribution of cells containing different hemoglobin levels.
The composition of cellular membranes changes in aging and AD.
The composition of gut microbial communities of HF patients was distinct from that of HC subjects in both unweighted and weighted UniFrac analyses.
The composition of the gut metabolome can be captured by measuring metabolite levels in the feces.
The composition of the peripheral blood lymphocyte compartment underlies developmental changes during ontogeny.
The composition of the preparation should be checked when changing dosage forms , or when switching brand-name drugs to generic drugs.
The composition of the transfersomes was statistically optimized by Design of Experiments using Box-Behnken design with four factors at three levels.
The composition of the waveforms may considerably differ for ERPs elicited by other auditory events.
The compote was proposed as a lunchtime dessert every two days for a period of three consecutive weeks.
The compound behaves as a selective and competitive inhibitor of mouse and human MAGL , which potently elevates hippocampal levels of 2-AG in mice.
The compound is known to accumulate in the RPE with age and was the first identified compound extracted from lipofuscin.
The compounds reduced d-Ser in PC-12 cells , but only MLA and ( R , S ) -dehydronorketamine were effective in 1321N1 cells.
The compounds retained both high SIRT2 selectivity and potent inhibitory activity.
The compounds specifically impacted the BCR-induced physical TCL1-AKT interaction.
The compounds were identified as nomilin glucoside and a novel ionone glucoside.
The comprehension of mechanisms and pathways leading to epigenetic modifications associated with ageing may help the development of anti-ageing therapies.
The comprehensive detection and delineation of these PTMs is critical for drug target discovery and validation.
The Comprehensive Geriatric Assessment ( CGA ) is a tool used to detect frailty.
The comprehensive review by Mastroeni et al.
The compromised BBB allows an influx of inflammatory cytokines to enter the brain.
The computed tomographic scans were converted into three-dimensional craniofacial models for each patient , using the initial and the follow-up computed tomographic scan data.
The computed tomographic scans were obtained during either natural sleep or with sedation and spontaneous ventilation without airway devices in place.
The ( COMT ) gene has been a candidate gene for BD.
The COMT genotype had significant effects on language performance and processing.
The concave and convex parts of the scoliotic discs were analyzed separately.
The concentration and activity of CXCL8 , CXCL1 , MMPs , and activin A were measured using ELISAs and specific assays.
The concentration of collagens IV and V was the same across age groups.
The concentration of injected and / or baseline platelets was rarely clarified ( @percent@ ) .
The concentration of more than fifty metabolites in the lens cortex and nucleus has been determined.
The concentration of nucleated cells was elevated compared with reported adult counts , while CD34 + percentage and CFU-GM counts were similar.
The concentration of the markers in the sample was based on physiological levels present in healthy adults.
The concentration ratio of acetonitrile to 3-EP increased substantially with aging.
The concentrations of chemokines and the degree of cell migration were determined by ELISA and chemotaxis assays , respectively.
The concentrations of Cr , Fe , Mn , and Co were significantly increased in the LR group ( p < @number@ ) .
The concentrations of serum triglycerides were determined by an enzymatic colorimetric method.
The concentrations of several cytokines in conditioned medium from DAs ( DA-CM ) were determined.
The concentrations of the free plasmatic metanephrines reflect the ongoing production of tumor.
The concept analysis facilitates a deeper understanding of communication during the patient encounter.
The concept and the process of retirement are rapidly evolving.
The concept of aging male is defined by an age in which might appear some clinical symptoms.
The concept of antioxidant therapies needs to be tested in well-defined randomized control trials.
The concept of a \ "polypill \ " is receiving growing attention to prevent cardiovascular disease.
The concept of augmentation has moved from simple lines , scars , and wrinkles to revolumizing the aging face.
The concept of cancer stem cells was proposed in the late 1990s.
The concept of cognitive reserve also has important implications for clinical practice in terms of diagnosis and prognosis.
The concept of early life programming is therefore widely accepted.
The concept of ease of acquisition and the dissociation between AA's general mental state and lexicon of kanji are also discussed.
The concept of evolving facial shape from a circle , to an upright triangle , to a square , to an inverted triangle is covered.
The concept of forecasting of environmental risks risks to population health from ecological factors of influence is formulated.
The concept of immunosenescence reflects changes in both cellular and serological immune responses throughout the process of generating specific response to foreign antigens.
The concept of personalized medicine is not new.
The concept of QOL was divided into two different approaches , ie , QOL as achievement and QOL as subjective well-being.
The concept of reserve is used to explain the observation that some individuals function better than others in the presence of brain pathology.
The concept of reserve may account for this imperfect relationship.
The concept of self-enhancement and generativity in middle-aged parents may explain the intergenerational differences in the association between parental disability and support.
The concept of social cognition is also introduced as one of the core functional domains that can be affected by a neurocognitive disorder.
The concept of social cognition refers to a set of skills and to emotional and social experiences regulating relationships between individuals.
The concept of social cognition thus refers to a multitude of skills.
The concept of social vulnerability is presented.
The concept of stressful cognitive dysfunction , which is under consideration in this review , allows picking out several therapeutic targets.
The concept of successful ageing was previously unfamiliar to participants , and their conceptualization of ageing derived from comparing themselves with their peers.
The concept of the program is empowerment for patients : a process to help patients make better healthcare decisions.
The concept of thriving encapsulates and explores experiences of well-being in relation to the place where a person lives.
The concept promotes patient-centered care , enabling goal adjustment by the patient and APN.
The concepts of ' house ' and ' home ' are compelling and contradictory.
The concepts of quality and value have become ubiquitous in discussions about health care , including cancer care.
The concepts of solvency , sustainability , and budget impact are common in discussions of Social Security , but are not well understood.
The concepts of \ "symptom inducer \ " and \ "symptom carrier \ " will also be addressed.
The conceptual foundation for the Healthy Ageing Model is described first , followed by a brief description of the key characteristics of the model.
The conceptual framework that frailty is a product of the environment and the recovery rate provides a new understanding of women's frailty burden.
The concept underlying this mechanism is that the life represents a lot of the interconnected physical and chemical processes moving by the bioenergetics.
The concerted action of a variety of integral membrane proteins mediates the transepithelial movement of solutes and water across the epithelium.
The concluding section discusses some implications for nursing home management.
The conclusion comments briefly on policy options to address these adverse trends.
The conclusion is made about the systemic CNS damage in liquidators as compared with healthy individuals.
The conclusion reached is that the study will provide material for reflection about the construction of a new reality about aging in Brazil.
The conclusions of this sobering analysis present challenges to current silvicultural practices and to those of the future.
The concordance between Abadie's sign and Achilles sonographic abnormalities needs to be evaluated in a larger sample to consider it useful for practical purposes.
The concreteness level was manipulated in order to modify the benefit of imagery and sentence strategies in relation to task characteristics.
The concurrent validity and test-retest reliability of the FaB-FC were respectively examined among subsamples including @number@ bilingual and @number@ unilingual participants.
The concurrent validity measured against the FES-I showed moderate correlation.
The concurrent validity of the PBS-ST scale scores were also examined in comparison with two sport-specific emotion-related measures and a general measure of affect.
The Condensed Protocol consolidates the same @number@ regions into @number@ tissue cassettes at ∼75% lower cost.
The condition affects both men and women , with an incidence that increases dramatically with age.
The conditional role of attachment style in stress-induced endogenous oxytocin production is highlighted.
The condition is also known as a neonatal progeroid syndrome.
The condition is associated with circulating inflammatory cytokines and sarcopenia , features that are shared with heart failure ( HF ) .
The condition is frequently associated with advancing age , structural cardiac dysfunction , and preexisting comorbidities.
The condition is particularly prevalent among older people , and the ageing UK population means this number is expected to rise.
The condition of oxidative stress reported in familial and sporadic forms of ALS prompted us to investigate Asn deamidation in ALS tissue.
The condyle / clivus ratio offers suboptimal results and cannot , therefore , be recommended.
The condyle / clivus ratio yielded low sensitivity for both 2D and 3D approaches.
The cone phases of these functions were identical.
The cone response of full-field ERG is a marker of retinal damage in macular pathology due to PVD.
The conference also promoted networking among developing researchers , leaders in the field of SCR and aging , and National Institutes of Health program personnel.
The conference brought together internationally renowned scientists and clinicians , who described the clinical and therapeutic relevance of translational research and its applications in neurorehabilitation.
The confidence of an individual should be considered if the eyewitness is a younger adult.
The confirmatory factor analysis provided an acceptable fit for the model.
The conflicting evidence leaves us recommending that metabolic monitoring be implemented , with regular follow-up as advocated in other populations.
The conflicting observations suggest that the contribution of A673T may be confined to Europeans and Americans rather than Asians.
The conflicting results might have resulted from the extent of BB metabolism by the cytochrome P-450 ( CYP2D6 ) isoenzyme.
The conformational range of the peptide revealed by NMR studies has been analyzed in terms of characteristic secondary features.
The conformity rate of prescription was better prior the distribution of the guidelines , respectively @percent@ and @percent@ ( p < 10⁻³ ) .
The confounding variables showed no statistical significance in the results.
The congress was held @date@ @number@ @number@ in Budapest , Hungary.
The conjunctiva usually accumulated on the nasal and temporal areas of the conjunctival sac ( @number@ eyes , @percent@ ) .
The connection between increased pain and a poor outcome has previously been shown.
The connectivity within the default-mode network , which contains both local and more distant nodes , also increases in strength with age.
The CONOR Mental Health Index , a seven-item self-report scale was used.
The consensus aging DMRs are significantly enriched for muscle biogenesis pathways.
The consensus recommendation addressed the most heavily used muscles to receive higher doses and to be injected into a larger number of sites.
The consequence is the increased risk of old , age-associated , neurodegenerative diseases.
The consequence of the process of resilient ageing was optimal quality of life.
The consequence of these effects is cytotoxicity and cell death.
The consequences of disclosing one's illness and its suffering are also explored.
The consequences of hip fractures in elderly individuals are significant in terms of years of life lost and reduction of the quality of life.
The consequences of our findings are discussed.
The consequences of pickiness may be malnutrition and , if prolonged , potentially lower body weight.
The consequences of short-duration intermittent exercise on heat storage with aging are unclear.
The consequences of SUMOylation are widely variable , depending on the physiological state of the cell and the attached SUMO isoform.
The consequences of these fungal infections are occasionally serious.
The conservation in both sequence and methylation patterns of the age-dependent CpGs indicate that the epigenetic clock is a fundamental feature of aging in mammals.
The conserved characteristics , defined neuroanatomy , and advanced technological application of Caenorhabditis elegans render this metazoan an unmatched tool for probing neurotoxic factors.
The conserved E3 ubiquitin ligase CHIP / CHN-1 contributes to proteostasis by ubiquitylating HSP70 and HSP90-interacting proteins.
The considerable growth in the elderly population in Turkey has brought with it problems as well as concerns regarding gerontological education for health care professionals.
The consideration of ancestral and prenatal stress effects on lifetime health trajectories is critical for improving strategies that support healthy development and successful aging.
The considerations emphasize the many important relationships ahead for possible future studies with many other fields.
The consistency across demographic variables is open to multiple interpretations.
The consistency of the components was assessed using ICASSO and the DMN was recognized through spatial correlation with a pre-defined template.
The consistency of these associations and their relationship to each other are unclear.
The consistency was good.
The Consortium to Establish a Registry for Alzheimer's Disease criteria and Braak stage were applied for semiquantitative grading of neuritic plaque and neurofibrillary tangle pathology.
The consortium to establish a registry of Alzheimer's disease test battery was used for neuropsychological assessment.
The constellation of symptoms comprising OAB affects ∼ @percent@ of the adult population and its prevalence increases with aging.
The constitutive triterpene saponins , ginsenosides , or panaxosides are attributed to ginseng's miraculous efficacy towards anti-aging , rejuvenating , and immune-potentiating benefits.
The construct of ideomotor-compatible tasks may comprise @number@ quite different classes of experimental procedures.
The construct of multimorbidity was initially developed and used in nongeriatric settings.
The construct of network type should be incorporated in mental health screening among older people who reside in the community.
The constructs are based on an engineered GFP gene containing recognition sites for a rare-cutting I-SceI endonuclease for induction of DSBs.
The construct variance of Sadness , and how this issue might be related to the assessment of depression in older adults , is discussed.
The consultant found that in @number@ patients ( @percent@ ) all three knee reflex methods examined produced similar results.
The consumption of alcoholic beverages and a higher waist-hip ratio remained independently associated with decreased high-density lipoprotein levels.
The consumption of beer was associated with use of tobacco between women ; and with marital status and schooling between men.
The consumption of distilled beverages was associated with schooling and use of tobacco between women ; and age and use of tobacco in men.
The consumption of foods and intake of nutrients was used as an outcome variable and was measured using a validated Food Frequency Questionnaire.
The consumption of other vitamin supplements has decreased.
The consumption of red meat , which is CML-AGE rich , has been positively associated with pancreatic cancer in men.
The content addresses personnel structure and assignment of responsibility ; details of interdisciplinary intervention protocols and implementation procedures ; and required personnel training.
The content of each dimension represents both culture-specific and culturally-universal elements.
The content of geranin ( @number@ mg / g extract ) was the highest among those of the @number@ identified phenolic compounds.
The content of vitamin B12 in the blood of the elderly has been closely linked to metabolic indicators and body mass.
The contents of sjTREC in human peripheral blood showed a decreasing tendency with aging.
The content validity index was @number@
The context of sampling may influence the likelihood of detecting senescent declines in GC functioning.
The ' Continental ' dietary pattern scores were significantly inversely correlated with plasma lutein and α-carotene ( r ( adj ) = -0·13 ) .
The continuation rate for quetiapine treatment during 6-month follow-up period was @percent@.
The continued presence of these factors prolongs the influx of inflammatory cells and factors , thereby leading to fibroblast dysfunction.
The continuous reaction times ( CRT ) method is used in screening for MHE.
The contralateral eye was used as a control.
The contrast and difference from the point spread function of the central centroids were evaluated.
The contrast between gray and white matter in MRI is critical for accurately measuring cortical thickness.
The contrasting effect was insignificant.
The contrasting patterns exhibited by felt age and ideal age reflect the complexities of age perceptions.
The contribution from these comorbidities to BBB compromise is great.
The contribution of aberrant EZH2 expression to tumorigenesis by directing cells toward a cancer stem cell ( CSC ) state is increasingly recognized.
The contribution of altered Ca ( 2 + ) signaling in the most important neurological disorders will then be considered.
The contribution of autophagy to age-related changes in the human skin is unclear.
The contribution of blast wind to injurious head acceleration may be a primary injury mechanism leading to blast-related TBI and CTE.
The contribution of C9ORF72 to ALS is notably lower in the Far East , but its role in other populations is unknown.
The contribution of CYP2C8 , 2C9 , and 2C19 to metabolism of apixaban was less significant.
The contribution of deficient telomerase activity to age-related decline in osteoblast functions and bone formation is poorly studied.
The contribution of each of the putative mediating variables was then calculated.
The contribution of each of these determinants to muscle weakness in old age is , however , largely unknown.
The contribution of ester formation to the naturally occurring components of lipofuscin was discounted since their fragmentation patterns were different to those found in vivo.
The contribution of mTBI to the amyloid accumulation requires further study , and mTBI patients should be recruited for longitudinal research with repeated amyloid-PET studies.
The contribution of other predictors was relatively small.
The contribution of retrospective memory and executive function to PM performance was assessed.
The contribution of retrospective thinking into the future that engages the same network as the one recruited when remembering the past is discussed.
The contribution of sensory nerve-mediated vasodilatation was lower in the older untrained group compared with all other groups ( P < @number@ ) .
The contribution of socioeconomic conditions was addressed by stratifying the sample into groups of high and low SES.
The contribution of the decline in thymic activity for the emergence of autoimmunity is still debatable.
The contribution of these aldehydes to ECM modification is not known.
The contribution of these @number@ factors varies between individuals with noticeable hereditary influence.
The contribution of vascular factors such as RAGE expression and CAA to the impairment of insulin signaling will be discussed.
The contributions are estimated for predictors amenable to intervention such as social capital.
The contributions of age , gender , school years , and vascular risk factors to the probability of conversion were estimated using logistic regression models.
The contributions of somatic mutations and noncoding microRNAs are also being explored.
The contributors to the changes in cell surface glycans were examined by real-time polymerase chain reaction or Western blot analysis.
The control and regulation of stem cells and their niche are remaining challenges for cell therapy and regenerative medicine on several tissues and organs.
The control comparison group received usual care plus two sessions of education and a depression brochure.
The control condition was @number@ °C and @percent@ RH.
The control counties ( @number@ counties ) received no intervention activities.
The control group ( CG ) , comprised of @number@ participants , mirrored the same age and gender status of the EG.
The control group completed a 10-week shoulder abductor stretching program.
The control group completed a 10-week shoulder abductor stretching program.
The control group comprised @number@ eyes ( @number@ subjects ) .
The control group comprised @number@ women who did not undergo any form of therapy.
The control group consisted of @number@ age-matched normal Japanese subjects ( @number@ males and @number@ females ) .
The control group consisted of @number@ healthy active subjects ( n 34 , @number@ ± @number@ years ) who have regular exercises other than swimming.
The control group consisted of @number@ premenopausal women ( mean age , @number@ y ) .
The control group consisted patients recruited from basic health care units.
The control group did not receive any intervention or attention except for the questionnaires.
The control group had greater sway velocity for all tests ( P < @number@ ) except Tandem eyes closed.
The control group had @number@ DPRs from normal BMD children.
The control group included @number@ age- and body mass index ( BMI ) -matched healthy young men ( age @time@ ± @number@ years ) .
The control group included @number@ children born full-term selected from one general practice in the district.
The control group included @number@ clean-up workers without mental disorders.
The control group included @number@ males and @number@ females , aging from @number@ to @number@ years [ mean ( @number@ ± @number@ ) ] .
The control group included @number@ patients ( @number@ females , @number@ males ) aging from @number@ to @number@ years without ARMD.
The control group ( n = 10 ) received conventional therapy alone.
The control group ( @number@ clusters , n = @number@ ) did not receive micronutrient powder until after the study period.
The control group presented worst performance in mental manipulation of information , abstraction , mental flexibility , and attention.
The control group provided significantly lower fracture strength.
The control group received a routine program.
The control group received no feedback.
The control group received no training during the eight weeks.
The control group received standard care , but no follow-up after discharge.
The control group received standard , mainly assessment-based occupational therapy services.
The control group received the usual care offered by the Primary Health Care Unit ( medical and nurse consultancies ) .
The control group received usual care.
The control group received vinorelbine @number@ mg / m ( @number@ ) days @number@ and @number@ with @number@ days as a cycle.
The control group showed more circadian variation in cardiac function.
The control group showed no appreciable improvements.
The control group sustained habitual food intake.
The control group underwent standard care , and the levosimendan group was administered levosimendan in addition to standard care.
The control group was composed of @number@ community-dwelling men aged @number@ and over.
The control group was stroke survivors using the usual care at a public geriatric day hospital.
The control group will receive the usual physiotherapy care.
The control group ( Younger Women ) consisted of @number@ women between the ages of 20-25 years ( posture stabilization period ) .
The control of cell fate by these two interconvertible lipids has been called the sphingolipid rheostat or sphingolipid biostat.
The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging.
The control of these transcriptional programs and the interpretation of the underlying genetic instruction is the task of the epigenome.
The control subjects demonstrated an increasing incidence of diastolic dysfunction with age , while systolic function was mostly unchanged with aging.
The control subjects were selected according to their age and educational level.
The controls were age- and- sex- matched , euglycemic children.
The controls were defined at start of follow-up in @number@
The CO ( @number@ ) laser for fractional treatment is used in super-pulse mode.
The conventional thinking was that HSC aging could not be reverted by therapeutic intervention.
The convergent validity and discriminant validity of the PDQ-8 were demonstrated by item-to-dimension correlations.
The conversion of the mechanisms of reversible disintegration into mechanisms of irreversible disintegration is the consequence of progressive evolution.
The co-occurrence of both MetS and higher cytokines levels was associated with greater increases in arterial stiffness and thickness.
The co-occurrence of diabetes and elevated depressive symptoms significantly accelerates cognitive decline over time , especially among those aged 50-64 years.
The coordinated function of different cell types and the regulated expression of molecular systems make possible the functionality of blood-brain barrier.
The coordinate locations describing the shape of each region were regressed with age to generate a model predicting the landmark location with age.
The COPA model improves the quality of care provided to very frail elderly patients by reducing unplanned hospitalizations and improving some health parameters.
The COPap and COPml time series were used to estimate the area and velocity of the COP.
The COP ( area , velocity ) was significantly higher for the younger individuals in the vestibular group than the younger controls.
The COP burden was estimated based on the surveillance data and national statistics.
The COPD prevalence in males was about two-fold higher than in females , and it increased with increasing age.
The coprimary end points were the cumulative incidences of new vertebral fractures at @number@ months and @number@ months.
The COP signals in both anteroposterior ( AP ) and mediolateral ( ML ) directions were analyzed respectively.
The copy number of AR gene in T24GR cells determined by PCR was twice as many as that of T24 cells.
The core and proximal promoter organization for Lim3A and a previously unknown mRNA named Lim3C were described.
The core barrier was the lack of commitment to the empowerment.
The core clinical criteria of the recommendations regarding AD dementia and MCI due to AD are intended to guide diagnosis in the clinical setting.
The core FTD spectrum disorders include behavioral variant FTD , nonfluent / agrammatic variant primary progressive aphasia , and semantic variant PPA.
The core observations come from @number@ studies with H.M. , an amnesic with cerebellar and HR damage but virtually no neocortical damage.
The core of the FRASER program includes patients admitted to hospital for ACS.
The core of the sarcopenia condition involves quantitative and qualitative losses of skeletal muscle.
The core of the stimulator is based on a microcontroller with two modular output stages.
The core topic of the results was : reconstructing ways to deal with the circumstances of dying and death.
The cornea flattens and there is an attrition of endothelial cells.
The Cornell Scale for Depression in Dementia ( CSDD ) was completed by nurses monthly for @number@ months.
The cornerstone of safety is careful preparation and treatment of comorbidities.
The coronary artery calcium score is a well-established marker of adverse cardiovascular outcomes.
The corpus callosum ( CC ) is particularly vulnerable to this type of injury.
The corpus callosum changes structurally throughout life , but most dramatically during childhood and adolescence.
The corpus callosum , the major connection between the cerebral hemispheres , grows constantly throughout childhood and adolescence.
The correct composition and functionality of this microbiome is essential for maintaining a \ "healthy status. \ "
The corrected item-total correlation was @number@ @date@ ( QoL-ADc ) and @number@ @date@ ( QoL-ADp ) .
The corrected paragraph appears in the correction. ]
The correction of FAO flux correlated with a marked increase in mutant CPT2 or VLCAD protein level , in cells treated by RSV.
The correction of volume loss has become an important part of facial rejuvenation treatments , particularly in the midface region.
The correct lateralization rate to the ipsilesional / contralesional stimuli was also calculated.
The correct regulation of the telomeric transcripts may be essential to genome stability , and altered TERRA levels associate with tumorigenesis and cellular senescence.
The correlates of age discrimination across the five discriminatory situations were similar.
The correlates of each measure were different : mostly clinical co-morbidities for WS , and mostly cognition and function for TMT-A speed.
The correlates of recognition memory included the medial temporal lobe and OFC , replicating prior studies.
The correlation between activity restriction and depression was positive and of large magnitude ( r = @number@ @percent@ CI , .34-0.44 ) .
The correlation between acupoints and motor points provides a model of acupoint selection to improve spasticity.
The correlation between age and cortical thickness showed a similar pattern in patients and controls , both globally and regionally.
The correlation between age and ED was statistically significant ( P value < @number@ ) with coefficient of @number@
The correlation between age and LUTS was statistically significant ( P value < @number@ ) with coefficient of @number@
The correlation between age and regional VMAT2 uptake was also examined.
The correlation between arteriolosclerosis and hippocampal sclerosis of ageing pathology was strong in multiple brain regions outside of the hippocampus.
The correlation between BP-GMD and age showed an inverted U shape followed by a U-shaped trajectory in most regions.
The correlation between CBF and clinical outcome was explored.
The correlation between circRNAs expression and clinical characteristics was analyzed in additional @number@ samples.
The correlation between Heidelberg and Zeiss subfoveal CT measurements was strong ( r = @number@ ) and significant ( P < @number@ ) .
The correlation between lncRNAs expression and NPC development has not been well identified in the recent literature.
The correlation between MAT performance and educational attainment was small.
The correlation between ordinal and interval variables was quantified by the Spearman rank correlation ( ρ ) .
The correlation between ovarian aging markers and AFCs was investigated.
The correlation between peak BOLD and PA was r ≥ @number@ P ≤ @number@
The correlation between pretreatment variables and outcomes was evaluated in a multivariate regression analysis.
The correlation between SEE-SV and self-assessed physical activity was r ( s ) = @number@ ( ns ) .
The correlation between the data generated by the two methods was modest ( R ( @number@ ) = @number@ ) .
The correlation between tongue and handgrip strength is consistent with the hypothesis that impaired oropharyngeal strength reflects global age-related declines in muscle strength.
The correlation between vaccine responses and age was examined with the Pearson test.
The correlation between working memory and reduced FA in frontal lobes is marginally significant ( p = 0.0787 ) .
The correlation between X-ray attenuation and sGAG optical density was then analyzed.
The correlation coefficient between corrected biological age and chronological age in males and females were @number@ and @number@ respectively.
The correlation coefficient between IPSS and SHIM scores were determined , and the scatter diagram was made.
The correlation coefficient in males and females were @number@ and @number@ respectively.
The correlation coefficients of @number@ nutrient intake measures and agreements on healthy eating classification between the two instruments were compared overall and by race.
The correlation improved when more studies were included compared to assessing only one study.
The correlation of AAR in human sclera and age at death is close enough to serve as basis for age estimation.
The correlation of HDL level and breastfeeding duration ( r1 = @number@ p < @number@ ) was found in the 1st group of children.
The correlation of Moray House Test scores between age @number@ and age @number@ was @number@ ( @number@ when corrected for range restriction ) .
The correlation of S with QoL1 and QoL2 scores was evaluated using Spearman's rank correlation tests.
The correlation of the CIRENS chronotype score was r = @number@ with the MEQ and r = @number@ with the MSFsc.
The correlation proved the reliable relationships between investigated variables.
The correlation remained significant for RA when AD was considered instead of dementia OR ( @percent@ CI ) @number@ ( @number@ @date@ ) .
The correlations among age , gender , and DA are variable.
The correlations among clinical factors , including radiographic factors , angiogenic factors , and angiogenesis , were statistically analyzed.
The correlations among such factors as ROM , OXY , oxidative index , and clinical characteristics were investigated.
The correlations among the @number@ occasions ranged from @number@ to @number@ reflecting substantial stability.
The correlations between androgen levels , DES composite scores , DES symptoms , and global , lipid , and aqueous tear film parameters were evaluated.
The correlations between health classes and socio-demographic factors were discussed.
The correlations between sarcopenia and cognitive impairment were expressed as crude and adjusted odds ratios with @percent@ confidence intervals ( CIs ) .
The correlations between the BMC values and the LM measures were stronger than the fat mass results.
The correlations between the NI-BUT , age , and gender were determined.
The correlations between these values and the axial length or age were evaluated using a partial correlation analysis.
The correlations , except for VFA were no longer significant with further adjustment for VFA.
The correlations of each choroidal structure and the age , sex , axial length ( AL ) , and refractive errors were calculated.
The correlations of genotypes with metabolic risks were then determined.
The correlations of the SURs to the clinical parameters were examined.
The correlative increase in age-associated diseases incidence has a profound public health impact and is an important matter of concern for our societies.
The correspondence bias was assessed in younger and older samples after death-related , negative , or neutral primes.
The correspondent opacity was @percent@.
The correspondent opacity was @percent@.
The correspondent opacity was @percent@.
The correspondent opacity was @percent@.
The corresponding 10-year mortality was @percent@ , @percent@ , and @percent@.
The corresponding 6-year incidence of dementia was @percent@.
The corresponding adjusted odds ratio for the association between anxiety and pain was @number@ ( @percent@ confidence interval @number@.0-4.8 ; P = 0.0363 ) .
The corresponding average SCCSA values were @number@ ± @number@ and @number@ ± @number@ mm.
The corresponding demographic information of age , body mass index , and comorbidities was evaluated using univariate analysis and univariate linear regression.
The corresponding difference for Mediterranean quintiles was @number@ ( P = @number@ ) .
The corresponding figures for mothers increased from @percent@ to @percent@ - more than double.
The corresponding figures for the direct differences in the VM between women and men are @number@ and @percent@ , respectively.
The corresponding figures in year @date@ were @percent@ , @percent@ , @percent@ and @percent@ respectively.
The corresponding gap between period and cohort life expectancies increases with time.
The corresponding increase in esterified cholesterol concentration was 10- and 40-fold , respectively.
The corresponding minimal detectable change values for the former were @number@ and @number@ and those for the latter were @number@ and @number@
The corresponding odds ratio was @number@ ( @percent@ CI @number@ to @number@ ) in the fully adjusted model.
The corresponding values were @number@ ( @number@.70-2.73 ) in white women and @number@ ( @number@ @date@ ) in AA women.
The corresponding α for the subscales were @number@ @number@ and @number@
The corroboration of this hypothesis will open new opportunities for the prevention and treatment of cancer.
The cortex was automatically segmented and parcellated , and phase shift was analyzed using an in-house developed method.
The cortical distribution of ipsilateral thalamocortical fibers was quantified by using a landmark-constrained conformal mapping technique.
The cortical neural synchronization is typically indexed by EEG power density.
The cortical surface is still expanding , reaching its maximum area during adolescence.
The corticospinal pathway is the major pathway connecting the brain with the muscles and is therefore highly relevant for movement control and motor learning.
The corticospinal tract , a major neural tract in the human brain for motor function , is concerned mainly with movement of the distal extremities.
The corticospinal tract ( CST ) is known to originate from multiple cerebral areas , including the primary motor cortex ( M1 ) .
The cortisol : DHEAS ratio and IL6 levels related to depressive symptom scores but not to neutrophil function.
The CORtisol NETwork ( CORNET ) consortium undertook genome wide association meta-analysis for plasma cortisol in @number@ Caucasian participants , replicated in @number@ participants.
The cosmeceuticals most likely to be used by younger children are moisturizers and sunscreens.
The cosmetic use of botulinum toxin ( BoNT ) is the most common cosmetic procedure performed in the world today.
The Costa Rican Government raised the amount of the non-contribution pension for the poor @percent@ before @date@ , and an additional @percent@ after that date.
The cost base year was @number@
The cost-effectiveness of long-term or life-long use should be examined in future research.
The cost-effectiveness of such strategies has not been analyzed.
The cost factor remained the principal reason , but other factors such as fear or accessibility problems were cited.
The cost impact of shorter hospital stays was offset by the increasing cost per day of hospitalization.
The cost of age-related diseases will only increase as the world's population continues to live longer.
The cost of caring for someone with Alzheimer's disease is magnified in the more severe stages of the disease.
The cost of health care in the United States continues to increase as an aging population places increasing demands on institutions providing health care.
The cost per person with dementia has decreased somewhat , mainly because of de-institutionalisation.
The costs and benefits of arousal in memory binding have been examined for younger adults but not for older adults.
The costs are expected to increase by @number@ % in @number@
The costs are expected to increase by @number@ % in @number@
The costs are expected to increase on average by @number@ % in @number@
The costs for society are substantial.
The co-twin control studies support the role of mid-life lifestyle factors for cognitive ageing and late-life dementia.
The counseling interventions lasted for @number@ months and were complemented by nicotine patches.
The counselling was either in-person at the patient's homes , or over the telephone.
The count of chronic conditions and functional disability were not associated with social support.
The couple's health context , that is , similarity or dissimilarity , was examined with an actor-partner interaction variable.
The coupling between gait and these cues was assessed using a perturbation paradigm.
The coupling was expressed by cross-correlation calculated in 1-min time windows.
The COURAGE in Europe Consortium recommends that future studies exploring determinants of health and disability in ageing use COURAGE-derived methodology.
The COURAGE Protocol for Ageing Studies has proven to be a valid tool for collecting comparable data in the ageing population.
The Courage-SNI is an instrument useful to identify high risk groups or populations whose social network is poorer.
The course and specificity of age changes in belief reasoning across the adult lifespan is unclear , as is the cause of the age effects.
The course is usually progressive with early lethality.
The course of a night's sleep is reported on a \ "hypnogram \ ".
The course of bereavement is influenced by a number of factors , including health problems , financial concerns , social support , and family relationships.
The course of MDD may be associated with brain aging modifications , including hippocampal , amigdalar and frontal volume reductions.
The course of the disease in the elderly is often complicated by co-morbid conditions , and its management is complicated by drug-drug interactions.
The course of the facial nerve branches to the corrugator supercilii muscle was much more predictable at their distal part than the proximal part.
The co-variables of cold , gender , obesity , and rapid ascents were not significant contributors to developing DCS in this study.
The covariance strength showing C-carriers > TT-carriers was the entorhinal-cingulum axis.
The coverage of cataract services was @percent@.
The COX-2 selectivity of NSAIDs can predict , at least in part , the GI toxicity.
The Cox model was used to estimate the multivariate-adjusted hazard ratios of incident functional disability.
The COXPRESdb ( @url@ provides gene coexpression relationships for animal species.
The Cox proportional hazard model was used to examine demographic and clinical characteristics ' effects on ill health retirement.
The Cox proportional hazards model and crude death rate were applied to estimate mortality risk.
The Cox proportional hazards model was used to determine the independent risk factors for recurrence within @number@ years after the operation.
The Cox proportional hazards model was used to estimate the relationship between the sex composition of offspring and parental mortality.
The Cox regression , with hazard ratios ( HR ) and @percent@ confidence intervals ( CI ) , was applied.
The CP-FI-CGA correlated well with the specialist-completed FI-CGA ( @number@ P < 0.05 ) .
The CpG island in first exon of OGG1 displayed hypermethylation in the DNA extracted from the lens cortex of ARC.
The CPM-mediated inhibition of the NFR , gauged by increases in NFR-threshold , did not differ significantly between groups ( p = @number@ ) .
The CPR duration increased with age ( P < 0.001 ) .
The CPR duration was defined as the time from CPR initiation by EMS providers to prehospital ROSC.
The CR and EX groups were significantly leaner than the WD group.
The cranial volume reaches its adult size in females at @number@ years of age and a year later in males.
The creams were based on the same base formula but differed with respect to the texture.
The creatinine clearance did not decrease in any circumstance.
The creatinine clearance was estimated using the Shull method.
The creatinine level was significantly reduced on the first postoperative day but reached the preoperative level towards the end of the observation period.
The CREDOS WMH visual rating scale showed excellent correlation with the automatically measured volume of WMH.
The CR group increased their treadmill test time and workload at @number@ and @number@ yr.
The CR hypothesis suggests several avenues for dementia prevention.
The cricoid is not round as has been observed in older children.
The CRIER represented the novel integration of cognitive test performance and depression self-report information.
The crisis imposed by ongoing drought and restricted use of water generated a strong impetus for adaptation , resilience and acceptance of change.
The criteria for defining ' progressive CKD ' need revisiting , as many patients exceed them.
The criteria from CHS and KFI correlated with each other , but SOF did not correlate with KFI.
The criteria of MetS recommended by the joint interim statement criteria were adopted.
The criteria were applied to medication reviews of @number@ ambulatory older Australian patients.
The criterion measure was the actual number of steps observed , counted with a manual tally counter.
The \ "criterion standard \ " for diagnosis was formal cognitive evaluation supplemented by input from an expert neurologist.
The critical appraisal was performed by two independent reviewers , and the data were extracted onto standardized forms.
The critical function of individual MMPs in tissue repair is also very important.
The critical impact that microbiota have on health and disease makes the interaction between host and microbiome increasingly important as we evaluate therapeutics.
The critical issues regarding the optimization of the gene silencing approach as well as the delivery strategies are discussed.
The CR model suggests the brain actively attempts to cope with brain damage by using pre-existing cognitive processing approaches or by enlisting compensatory approaches.
The Cronbach alpha value was high ( 0·89 ) .
The Cronbach's alpha of the subscales ranged from @number@ to @number@
The Cronbach's alpha was @number@ for the total scale.
The Cronbach's CONCLUSION : P-SASS has good reliability and validity for older adults.
The Cronbach's α of the HCS was @number@ and test-retest reliability was r = 0.71.
The cross-lagged paths from young adult AUD to adult CUD and young adult CUD to adult AUD were both nonsignificant.
The crosslinking of collagen in the body can form via two mechanisms : one is enzymatic crosslinking and the other is nonenzymatic crosslinking.
The cross-modal priming is a way to verify the nature of knowledge.
The cross-sectional and longitudinal findings converged on the idea that affect-whether positive or negative , global or experiential-decreases as a function of age and time.
The cross-sectional data were analysed with partial association and analysis of variance and covariance.
The cross-sectional data yielded that morning types were less common in the 2000s than two decades earlier.
The cross-sectional observation of overrecruitment reflected a select elderly sample.
The cross-sectional study was conducted on @number@ healthy Chinese women ( 20-80 years old ) .
The cross-seeding effect of actin was stronger but that of fibroin was weaker than that of other proteins.
The crosstalk in the functional interplay of the neuroimmune system is essential to ensure homeostasis preservation and health.
The cross-validated area under the ROC curve for this model was @number@ ( CI : @number@.69-0.97 ) .
The cross-validation was performed based on differences between the two groups in both frequency values and ages.
The crotonaldehyde modified DNA induced high titer antibodies in experimental animals which showed high specificity towards the immunogen.
The crowns were loaded at a 30-degree angle in a universal testing machine until fracture or bending.
The CRQ is associated with the cognitive performance of executive functioning.
The CRT index , however , was independent of age and gender in both groups.
The crucial role of MMP-13 is further underlined by reduced OA pathology in MMP-13 deficient mice.
The crucial step in AD pathogenesis is the production of amyloid-β42 peptide , which causes chronic inflammation.
The crude and adjusted odds ratios were @number@ ( @percent@ CI , @number@.297-3.728 ) and @number@ ( @percent@ CI , @number@.210-4.168 ) , respectively.
The crude and adjusted rates of surgeries were usually higher in lower economic status groups.
The crystal structure of CBDP-inhibited BChE confirmed that the phosphate adduct is the ultimate aging product.
The crystal structure of the five-subunit human Ragulator at @number@ Å resolution was determined.
The CS concentration and chain length were determined using high-performance liquid chromatography ( HPLC ) and gel filtration chromatography , respectively.
The CSDH series appeared in the literature was also reviewed.
The CSF biomarkers Aβ42 , t-tau , and p-tau181 were assessed.
The CSF biomarkers β-amyloid 1-42 , total tau , and phosphorylated tau at threonine @number@ were measured with commercially available assays.
The CSF cytokines were one to three orders of magnitude higher compared to the plasma.
The CSF F2-IsoP concentration increased by approximately more than @percent@ for every 5-U increase in body mass index ( P < @number@ ) .
The CSL is a single point of entry system to link caregivers to national and local services to support care of a veteran.
The CSMP expressed in watts ( velocity × load ) for each repetition was assessed by a device that measures mean velocity.
The C-statistic for 10-year CVD risk increased from @number@ by @number@ ( 95%CI @number@ @date@ ) with CTCS.
The C-statistic for the final model was significantly improved over the Health ABC model alone ( @number@ vs. @number@ p = @number@ ) .
The CST mental health and trauma items did not perform well as scales with Cronbach's alphas of @number@ and @number@ respectively.
The CST-SA is a short , reliable , and valid measure of SA.
The C-terminal @number@ kDa fragment of TDP-43 was unstable but remarkably aggregation-prone.
The C-terminal region containing the zinc-finger domains negatively regulates chromosome alignment , and phosphorylation in the FPE region counteracts this regulation.
The CTL group did not demonstrate significant changes.
The CTX levels were also similar for all the groups before treatment.
The cueing paradigm provides an established method for eliciting involuntary and voluntary attention shifts.
The cue-locked ERP ( P3a ) data revealed an age-related decrease in neural activity related to the processing of switch cues.
The cultural aspects of cognitive aging are examined , especially the role of stigma and stereotype threat.
The cultural-historical background and sociopolitical conditions of each diverse group poses unique challenges in developing successful recruitment and retention methods and strategies.
The cultures of the biopsy specimen yielded yellow-green colored , granular mold colonies and creamy white yeast colonies.
The cumulative damage provided by RA was most pronounced in patients with disease duration ≥10 years.
The cumulative development rate of CKD was @percent@ at the 5th year and @percent@ at the 10th year.
The cumulative effects of cellular senescence and cell loss over time in various tissues and organs are considered major contributing factors to the ageing process.
The cumulative incidence of a first VTA through @number@ years of follow-up was significantly lower in older patients than in younger patients.
The cumulative incidence of Bell's palsy was found to be @number@.3 / 100.000 / year.
The cumulative incidence of dementia was @percent@ at @number@ year , @percent@ at @number@ @percent@ at @number@ @percent@ at @number@ and @percent@ at @number@ years.
The cumulative incidence of diabetes among groups was estimated according to baseline serum 25OHD levels.
The cumulative incidence of extracolonic Lynch syndrome-associated cancer was significantly lower with suspected familial colorectal cancer type X than with Lynch syndrome.
The cumulative incidence of LTC admission was @number@ per cent by @number@ months.
The cumulative incidence of PCa mortality was @percent@ [ @percent@ confidence interval ( CI ) @number@ @number@ ] after @number@ years.
The cumulative mortality rate was @percent@ after @number@ year and @percent@ after @number@ years.
The cumulative platinum dose was significantly associated with risk of higher LH levels at both surveys and higher FSH at SI.
The cumulative probabilities of sustained response were calculated using the Kaplan-Meier.
The cupula and lumina of the semicircular canals were examined for evidence of deposits.
The CURB65 scores were calculated from information obtained at initial hospital presentation.
The CURB65 score was developed to predict mortality risk in community acquired pneumonia.
The current analyses further explored the SIB-8 scale with respect to its validity and sensitivity.
The current analysis focused on three medication groups : anxiolytics , sedatives / hypnotics and antidepressants.
The current analysis reexamines the relationship between supplemental vitamin E and all-cause mortality.
The current animal literature suggests that females tend to be more active than males due to biological pathways of estrogenic origin.
The current article aims to contribute to the understanding of innovation in healthcare services.
The current article explores strategies to improve participation in cognitive aging research by older adults , particularly minority older adults.
The current article presents concrete requirements and recommendations for deploying cognitive training software in older adult residential homes.
The current article presents highlights from the @number@ meeting.
The current article provides an overview of the potential of cannabinoids in the treatment of LOAD and related neuropsychiatric symptoms in older people.
The current challenge is to promote osteoblastogenesis and bone formation to prevent age-related bone deterioration.
The current cognitive subtypes have some validity and utility but additional approaches should be explored so as to enhance these properties.
The current consensus suggests that PD develops from multiple risk factors including aging , genetic predisposition , and environmental exposure.
The current data , as well as published studies showing cerebrovascular activation in human AD , support further exploration of vascular-based mechanisms in AD pathogenesis.
The current data suggest several compounds worthy of further study as treatments for AD.
The current disputable evidence does not allow definite conclusions as to whether statins contribute to , or cause , clinically meaningful cognitive impairment.
The current efforts to reinvent the nursing home perpetuate a flawed model of care.
The current evidence for the implication of LPO in pathological processes is discussed in this review.
The current evidence is insufficient to determine the safest , most beneficial hypertension regimen in older adults.
The current financial crisis is putting a strain on this system.
The current findings confirm lower late-life BMI confers increased odds for ADNP.
The current findings facilitate an understanding of the molecular and cellular mechanisms of HDAC7 in the regulation of hippocampal-dependent memory.
The current findings of an age-related deterioration in the ability to discriminate lifted weight extend and disambiguate the results of earlier research.
The current fMRI study investigates the neural foundations of evaluating oneself and others during early adolescence and young adulthood.
The current healthcare systems are built around the traditional paradigm of patients suffering from a single acute illness.
The current interpretation is that these restrictions are a general defense against the proliferation of any tumoral mass.
The current intervention occurs over a 48-month period , using a manual , newsletters , and phone coaching calls.
The current investigation also provides SLCrel data for healthy people which can be compared with patient populations.
The current investigation assessed the effect of acute caffeine administration on working memory during the earliest stage of cognitive decline in elderly participants.
The current literature does not provide sufficient evidence of the physical functioning consequences of gardening.
The currently recommended TEG cut-off values were poorly predictive of vascular obstruction and modestly predictive of hemorrhage.
The current mainstay of pharmacological therapy for OAB is antimuscarinic agents.
The current management of colorectal cancer ( CRC ) would greatly benefit from non-invasive prognostic biomarkers indicative of clinicopathological tumor characteristics.
The current management of EOS remains empiric because of the lack of randomized , controlled studies.
The current nursing workforce is aging , and large numbers of retirements are anticipated.
The current obesity epidemic has contributed to this high prevalence rate.
The current paper explores this question and suggests new research avenues.
The current population of nurses is aging and rapidly approaching retirement , and graduation of new nurses is not expected to meet demand.
The current produces a major impact on the resting membrane potential of basal neurons.
The current quantity of such services is @number@.11×10⁸ and underprovided by @percent@.
The current report describes two siblings with severe neurologic abnormality and premature aging.
The current research aimed to identify variables that independently affect behavior trends in PAL over the course of two years among elderly.
The current research challenge is to determine the primary pathways contributing to ' non- or epi-genetic ' causes of excess adult weight gain and adiposity.
The current research extended beyond this initial study to provide more definitive evidence for relative preservation of memory-based automaticity in reading tasks for older adults.
The current research investigated the role of practice effects in longitudinal comparisons on the discrepancy.
The current results are the first to provide neural evidence for an age-related reduction in processes that support intentional forgetting.
The current results indicated that miR-124 increases as a result of cell senescence and that it decreases during tumorigenesis.
The current results indicate that the calculation of QSM contrasts contributes to an improved visualization of the entire STN.
The current results suggest that tomatoes and ferulic acid may contribute to prevention of chronic inflammatory diseases.
The current review analyzed this random sample and further selected trials when the reported mean age was ≥ @number@ years.
The current review article is divided into two parts.
The current review considers one possible neural network , which may contribute to cognitive reserve.
The current review focuses on the potential of Drosophila melanogaster for the identification of medicinal / pharmacological properties associated with plants / plant-derived components.
The current review focuses on the roles of opioid systems in blood vessels , especially angiogenesis , during development and tumour malignancy.
The current review integrates recent findings regarding the construct of self-awareness in dementia from both clinical and cognitive perspectives.
The current sample of ET cases demonstrates a reduction in Purkinje cell number relative to that of controls.
The current situation , providing universal coverage for residents aged @number@ years and over , may not be sufficient for equality in care.
The current state of knowledge is summarized and open questions and emerging fields of research are discussed.
The current state of research indicates that oral fibroblasts possess unique characteristics and tightly controlled specific functions in wound healing and repair.
The current status of ICT-supported services is described and examples of how these services can be implemented in everyday practice are given.
The current status of the management of common and important congenital cardiac defects is also described.
The current studies examined the effect of taking a standard memory test on older adults ' subjective age.
The current study addressed the question whether audiovisual ( AV ) speech can improve speech perception in older and younger adults in a noisy environment.
The current study aimed to determine the potential mechanism ( s ) by which mTOR inhibition modulates cardiac proteasome.
The current study aimed to examine the relation between Mediterranean-type diet and LTL.
The current study aimed to examine the salience of anxiety-provoking social situations for older adults.
The current study aimed to provide extended age- and gender-specific norms for the German AVLT for individuals older than @number@ years.
The current study aims to explore the outcomes of TPN use in older adults which are at present poorly defined.
The current study aims to provide a comprehensive snapshot of operational definitions of SA.
The current study analyzed the extent and mechanisms of attenuating associations in a cardiovascular patient cohort.
The current study begins the exploration of relationship-defining memories ( i.e. , the first time someone met their spouse ) across adulthood.
The current study builds upon previous research examining the reliability and validity of responses to a brief Hebrew language version of the Zarit Burden Interview.
The current study characterized age-related differences in electrocortical processes during the performance of discrete aiming movements in children and adults.
The current study compared the expression of microRNAs in young facial skin and senescent facial skin , and this study identified skin aging-related microRNAs.
The current study documents the expression of prohibitins in human and rodent islets and their key role for β-cell function and survival.
The current study evaluates the potential medication cost savings of adding personalized pharmacogenetic information to traditional medication management strategies.
The current study examined correlates , moderators , and mediators of functional impairment in @number@ treatment-seeking adults with obsessive-compulsive disorder ( OCD ) .
The current study examined the association between depressive symptoms and all-cause and cause-specific mortality in Chinese older people.
The current study examined the correspondence between valence ratings and emotional word use in young and older adults ' autobiographical memories.
The current study examined the effects of two manipulations on equal and expanded spaced retrieval schedules in young and older adults.
The current study examined the impact of cognitive impairment and its severity on Spatial Span performance.
The current study examined the implications of war captivity and depression / PTSD trajectories on telomere length.
The current study examined their validity in a sample of @number@ women ( 30-75 years ) in multiple ways.
The current study examined the prevalence and course of neuropsychiatric symptoms in a large sample of patients with dementia attending memory clinics.
The current study examined the relations between distinct functions of social support and numerous cognitive domains in older adults.
The current study examined the role of temporal resolution of attention in the decline in multiple object tracking abilities with healthy aging.
The current study examined TRI while manipulating older adults ' performance-related concerns.
The current study examined whether reduced physical activity increases risk for cognitive impairment and brain hypoperfusion over time in HF.
The current study examines the EEG coherence of young , old , and old declined adults performing a visual paired-associates task.
The current study examines the impact of physical activity on odds of physical and functional limitations in older adults with central and general obesity.
The current study examines the possible contribution of temporal modifications in the often-reported posterior-anterior shift.
The current study examines the prevalence and correlates of homebound status aiming to elucidate the predictors and implications of being homebound.
The current study examines whether social and environmental correlates of depression are similar in men and women.
The current study explored this relationship in @number@ volunteers aged sixty years and older.
The current study explored whether older adults can use their preserved metacognitive knowledge to make source guesses in the absence of source memory.
The current study focused on analysis of factors associated with osmotic imbalance and oxidative stress in aging and diabetic human cataractous lenses.
The current study focuses on the characteristics of older people with intellectual disabilities with the lowest frailty levels.
The current study found that psychology students demonstrated greater aging knowledge than medical students ; however , both groups showed gaps in knowledge about sexuality.
The current study further addressed this question by testing whether motor asymmetry was reduced in a sample of @number@ healthy right-handed adults ages 65-89.
The current study helps to elucidate the role of risk and resilience factors when adults are faced with daily stress.
The current study identified a number of limitations in the field of perceptual-motor research.
The current study included @number@ participants ( @number@ females and @number@ males ) aged between @number@ and 79years from the Tasmanian Healthy Brain Project.
The current study included one of the most widely-used measures of attentional bias , the dot-probe task ( Mathews & MacLeod , @number@ ) .
The current study investigated age differences in the use of attentional deployment , positive reappraisal and suppression while regulating responses to sadness-eliciting content.
The current study investigated how the recovery response is moderated by age , walking speed , muscle strength and speed of information processing.
The current study investigated the developmental trajectory of infants ' sensitivity to these two situational input cues in word recognition.
The current study investigated the effects of aging on the neural basis underlying true and false recollection.
The current study investigated the extent to which young and older adults are able to direct attention to distinct processes in mapping spelling onto sound.
The current study investigated the impact of APOEε4 status on the relationship between biomarkers of cardiovascular risk , systemic inflammation , and NPS.
The current study investigated the independent factors associated with successful H. pylori eradication using a multiple logistic regression analysis.
The current study investigated the nature of the flow state among older adults.
The current study investigated the relationship between plasma HCY and hsTnT levels in a community-based population.
The current study investigated the upper extremity movements during typical assembly tasks using the framework of the UCM analysis.
The current study investigated whether age increased the variability in text based global inference generation a measure of crystallized intelligence.
The current study investigated whether a reduction in attentional resources for processing of relational information ( i.e. , relational attention ) underlies age-related RM deficits.
The current study investigated whether neuroplastic changes in the visual pathway can persist in older adults.
The current study investigates cognitive processes as reflected in late auditory-evoked potentials as a function of longitudinal auditory learning.
The current study investigates this link by clustering characteristics of network members nominated by older adults in Lebanon.
The current study is a follow-up of a previous study conducted @number@ years ago with the same participants.
The current study is a preliminary literature review regarding the influence of light on the visual functioning of the aging workforce and their related tasks.
The current study is investigating aging , cognitive decline , and dementia in older urban / regional Aboriginal Australians.
The current study provides first evidence regarding the psychometric properties of the SMMSE score in a sample of older primary care patients.
The current study provides new insights in the role of the cerebellum in manual motor performance.
The current study provides normative data stratified by estimated quality of education as indexed by irregular word reading skill.
The current study quantified age-related changes across SI and SII mainly based on oscillatory activity indices measured with magnetoencephalography.
The current study results provide an insight into this paradox.
The current study's findings demonstrate the potential of directing implicit processes toward physical-function enhancement over time.
The current study sought to examine the factors associated with freedom from neurocognitive impairment in older HIV-infected adults.
The current study sought to explore whether warnings could be tailored to specifically reduce false recall of categorical information in both younger and older populations.
The current study sought to identify baseline factors associated with treatment outcome in major depression , diagnosed according to DSM-IV criteria.
The current study sought to investigate whether envelope colour affected response rates in a study about the effectiveness of screening older women for osteoporosis.
The current study successfully developed a multimedia text-based screening system.
The current study supplements and corroborates existing literature that shows that older adults demonstrate lower tongue strength than younger adults.
The current study tested the hypothesis of an association between brain aging and synaptic protein loss across males and females.
The current study tested two possible mediators ( physical health and cognitive functioning ) of the link between conscientiousness and longevity.
The current study thus investigated whether the self-reported frequency of sexual intercourse was related to memory function in healthy female college students.
The current study used falls direction to categorize falls and explore age-related effects on the biomechanics of medio-lateral balance control.
The current study used this framework to investigate age differences in description-based and experience-based decision-making tasks.
The current study was an intervention study examining the effects of a high-fiber , low-fat diet on periodontal disease markers in high-risk subjects.
The current study was conducted to investigate the role of general slowing , as measured by Trail-Making-Test-A , in age-related alterations of Stroop interference.
The current study was designed to look for individual differences in selective attention ability and to see if any such differences correlate with age.
The current study was limited to adults age @number@ and older.
The current study was restricted to participants who were followed up past the age of @number@
The current systematic review aimed to evaluate research pertaining to the impact of arts and health interventions on cognition in people with dementia.
The current treatment modalities utilizing UVR ( i.e. phototherapy ) can also predispose to skin cancers.
The current understanding of the experiences of elderly males with LUTS is considerably limited.
The current understanding of the pathogenesis of GCA is explored.
The current version of euL1db centralizes results obtained in @number@ studies.
The current version of MitProNet covers @number@ high-confidence proteins , and the remainders were further classified as middle- or low-confidence.
The current work addressed this question.
The current work demonstrates that exposure to ethanol during adolescent development can produce long-lasting detrimental impairments.
The curriculum is currently being piloted and evaluated.
The curve's lowest point , the optimal blood pressure , does not appear to be the same for all patients.
The cushioning function of large arteries encompasses distension during systole and recoil during diastole which transforms pulsatile flow into a steady flow in the microcirculation.
The CUSPAD , soliciting the most items , presented the highest prevalence rates.
The cut-off levels for eGFR are not yet clear.
The cutoffs identified could be used as a lifestyle-based risk index for DM.
The cut-off thresholds for grip strength were defined separately for men and women of different ages using a weighted polynomial regression.
The cutoff value at 97th percentile was @number@ U / mL.
The cutoff value is @number@
The cutoff value of uAm / uCr was @number@ with a sensitivity of @percent@ and a specificity of @percent@.
The Cutometer has been widely used to evaluate skin elasticity and its change with aging.
The cut-point for sc- @time@ correlating with the presence of > 1 VFx was @number@ nmol / L ( sensitivity @number@ specificity @number@ ) .
The cutting-edge promise is gene therapy although both the delivery and efficacy of the numerous transgenes remain under investigation.
The Cuzick test and the Cochran-Armitage test were used to determine the significance of changes over time.
The CV cells generate an inflammatory defense in an attempt to limit the molecular disorder.
The cVEMP amplitude increased as a function of EMG target level for each age group.
The CVM grade could not predict the change of cephalometric variables.
The CVs for LERTD and HGRFD were ≤ @time@ %.
The CWI psychometric properties were studied using Rasch analysis.
The cyclodextrin polymer-based system now in clinical trials offers optimism that polyplexes may potentially be used for RNAi-mediated cancer intervention in the clinic.
The cystic fibrosis transmembrane conductance regulator ( CFTR ) has been shown to play an essential role in fertilizing capacity of sperm and male fertility.
The cytochrome P450 2D6 ( CYP2D6 ) belongs to a group of CYPs considered of utmost importance in the metabolism of xenobiotics.
The cytochrome P450 ( CYP ) 2D6 genotype of the patients was determined.
The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production.
The cytokine IFN-α is secreted during viral infections and has been shown to inhibit telomerase activity and accelerate T cell differentiation in vivo.
The cytokine-induced loss of methylation status in the IL1B promoter was ameliorated by both GlcN and BAY to @percent@ and @percent@ , respectively.
The cytokines IL-1β , IL-6 and IL- @date@ be helpful in NPH diagnostics.
The cytopathological hallmark of multiple system atrophy is the accumulation of α-synuclein aggregates in oligodendrocytes , forming glial cytoplasmic inclusions.
The cytoplasmic domain of band @number@ serves as a center of erythrocyte membrane organization and constitutes the major substrate of erythrocyte tyrosine kinases.
The cytoplasm , nucleus and mitochondria have been considered primary targets for gene delivery using targeting moieties or environment-responsive materials.
The cytoregulatory role of G6PD has largely been overlooked.
The cytotoxicity and hydrophobicity of heme necessitate that heme mobilization be carefully controlled to mitigate the deleterious effects of this essential toxin.
The cytotoxicity and photocytotoxicity of the carriers were examined with or without their load.
The cytotoxicity of DNA-protein crosslinks ( DPCs ) is largely ascribed to their ability to block the progression of DNA replication.
The cytotoxicity of extracts ( at @number@ @date@ mg / ml ) was determined with human skin fibroblasts.
The cytotoxicity of fibroblasts was evaluated by SRB assay for the purposes of selecting non-toxic doses for further experiments.
The cytotoxicity of isolated compounds was tested against two cancer cell lines ( PC3 and MCF-7 ) , and normal lymphocytes.
The cytotoxicity of these vegetable oils was assessed in vivo on 8-week-old mice and in vitro by using the neutral red and YO-PRO-1 tests.
The D2S2 risk assessment tool can be installed easily in existing EHR systems.
The D : A : D models also more accurately predicted five-year CVD-risk for key prognostic subgroups.
The daily consumption of two servings of soft plain cheese was well accepted in terms of tastiness and appetite suited portion size.
The daily intake portion for milk , cheese and yoghurt was calculated from food frequency questionnaire ( FFQ ) responses.
The daily mean BG decreased from @time@ ± @number@ to @number@ ± @number@ mmol / l ( @percent@ , p < @number@ ) .
The daily step count , and the time in moderate ( incl. walking ) and low activity and sedentary behavior were assessed.
The damage accumulation theory is one of the most accepted theories due to the large body of evidence found over the years.
The damage appears as horizontal , flap , or complex tears ; meniscal maceration ; or destruction.
The damping ratio was above unity for most data in young adults and below unity for older adults.
The dancers have a visual dependence to control the postural balance.
The dangerous convergence of small typefaces , dim lighting , aging nurses.
The DASH score was significantly higher in the OA group and increased according to the grade of shoulder OA ( P < @number@ ) .
The DAS remains installed in the vehicle for six months while the participant goes about his / her normal driving with no imposed study restrictions.
The data also highlight the usefulness of determining fiber-size-based clusters for gaining mechanistic insight into the relationship between skeletal muscle fiber size and myonuclear content.
The data also provided evidence against rule-specificity , as single-dimensional rules could not explain age declines.
The data also showed that several pathways are affected in DS , including PI3K-Akt signaling.
The data also suggest that excessive intramuscular fat accumulation could be the initial trigger for p53 activation and consequent loss of muscle mass and strength.
The data also suggest that p.R47H is associated with an FTD phenotype that is characterized by the presence of underlying AD pathology.
The data also suggest that proactive interference did not significantly contribute to the forgetting rates for monkeys or younger children.
The data analysis targeted P-E fit ( i.e. accessibility ) problems , including studying the personal and environmental components separately.
The data analysis was based on content analysis.
The data analysis was explorative and descriptive.
The data are based on linkages between the Utah Population Database and Medicare claims that hold medical diagnoses data.
The data are discussed in terms of age differences in resource demanding strategy use during a semantic word matching task , specifically during controlled retrieval.
The data are drawn from two Swedish television documentaries on health encounters.
The data are evidence that sensitivity of the post-receptor retina improves in those with a history of mild ROP.
The data are from focus group discussions conducted in seven villages in Nang Rong district , northeastern Thailand.
The database at baseline also included a broad set of sociodemographic , behavioral , and health status covariates.
The database can be accessed at @url@ and all the stored data can be viewed with a guest account.
The database has shown that the basic diagnostic work-up programme with MMSE , and a brain scan is performed in almost all patients.
The databases are freely available for down-loading from the Psychonomic Society Web archive at www.psychonomic.org / archive / .
The databases were searched for English language papers focusing on human studies published relating cognitive functioning to sexual behavior in the aging population.
The data came from a longitudinal population-based sample of @number@ participants interviewed at 3-year intervals from @number@ to @number@
The data collected are in part consistent to provide a longitudinal overview for treatment access , but topical items are included such as ageing.
The data collected by the app characterizes accuracy , reaction times , and speed of movement.
The data collection targets environmental factors such as assistive devices , social support , physical environmental barriers , accessibility problems and perceived aspects of home.
The data consisted of thoracic and lumbar vertebral angles relative to a fixed plane , as well as vertebra-to-front skin and spine-to-back skin distances.
The data consist of eight group interviews of Finnish middle-agers ( 50-65years ) .
The data consist of telephone conversations between a psychotherapist and people seeking help for their life difficulties on a Swedish radio programme.
The data contains self-reported functional and clinically-measured hearing ability for a representative sample of the Danish population aged 50-64.
The data extend evidence of fast , emotional modulation of stepping , with theoretical and applied consequences.
The data extracted by one reviewer was verified by a second experienced reviewer.
The data extracted from these studies were synthetized into metathemes.
The data for episodic memory are the most robust.
The data for @number@ subjects were included in the analysis.
The data from limited institutions in many Asian countries seem to bias the true incidence and mortality rates.
The data from our study were overlayed using the @date@ STATA software package.
The data from the official race results showed @number@ age class competitors that provided @number@ sets of observations.
The data from this study suggest that Pure Gold Collagen can counteract signs of natural aging.
The data further suggest that CD should be considered in patients with small bowel adenocarcinoma , particularly when the tumors display MSI.
The data gathered in clinical examination give useful information for the assessment of walking ability in relatively healthy older women.
The data gathered were used to compare oral fibroblasts with fibroblasts from other tissues in terms of their regulation and function during wound healing.
The data generated from this study suggest that the revised method can be reliable for age estimation on a modern European population.
The data has generated a non-cohesive sketch of the process.
The data highlight the importance of the brain microcirculation in the pathogenesis and evolution of AD.
The data included age , sex , place , and diagnosis.
The data including history , physical examination , laboratory tests , diagnosis , treatment and follow-up were collected and analyzed.
The data indicated a significant decrease in visual acuity as a result of the half-mile test.
The data indicate that the efficacy of fesoterodine in elderly patients is comparable with that in younger patients.
The data indicate that the highest binding affinities and functional activities were produced by methyl and ethyl substituents at the α ' position.
The data in elderly cohort do not confirm previously reported role of ACE DD genotype to the development of HT.
The data obtained open the new ability for patogenetic treatment of various age patients with chronic parodontitis using the EHF- and IR-electromagnetic emanation method.
The data obtained provide a basis for the elaboration of medical and social programs aimed at increasing life expectancy.
The data obtained were statistically analyzed by two-way analysis of variance and the Tukey test ( α = 0.05 ) .
The data of @number@ older participants were analyzed in this study.
The data of @number@ subject were excluded due to non-compliance to study medication.
The data of our study suggest that BFCS morphometry may provide an emerging biomarker in AD.
The data of patients with and without diabetes and / or hypertension were compared.
The data of the research was collected using a questionnaire that determined the descriptive and UCLA Loneliness Scale ( UCLA-LS ) .
The data on the effects of aerobic training on plasma antioxidant vitamins are conflicting.
The data on the functional results are , however , promising for dysphagia interventions.
The data originated from the Linnaeus database , available at the Center for Population Studies , Umeå University , Sweden.
The data originates from the SIESTA project database established in the late 1990s.
The data period examined in this study was only @number@ years.
The data points from two walks in each level of each condition were examined for linear and quadratic relationships.
The data presented may be of utility to prevent premature aging of reproductive function.
The data provide a mechanistic explanation for why senile plaques are present preferentially near the cerebral vasculature.
The data provide evidence that altered expression of DNA repair genes is associated with pathogenesis of ARC.
The data represented @number@ individuals in @number@ of @number@ Swedish municipalities.
The data resource will continue to be updated with data across additional waves of these surveys and new waves.
The data revealed a continual increase of basal CD4 + IL23R + cell amounts in the different age groups.
The data revealed that most participants actively sought to explain their symptoms.
The dataset and code used in this study are publicly available.
The data set consisted of client level home care data from service agencies around the world.
The data should greatly contribute to the development of molecular evaluation of sperm quality , and the diagnosis and treatment of asthenozoospermia.
The data should help to encourage effective strategies concerning public health policies for this population.
The data showed a gradual increase in the mean age of workers , especially among subjects with restrictions / requirements regarding their job title.
The data showed that part of elderly suffered influence of advertisement to medication use , and are not conscious of risks involved.
The data showed that the participants with lower IQ had a higher incidence of epileptic seizures.
The data show previously unidentified connections between UPS and calpain-based degradative systems and advance our understanding of roles for Ub K6 in eye development.
The data shows cancer prevalence and cancer incidence increases until ages 85-89 , after which the rates decrease into 100 + ages.
The data show that dancing improves minimum foot clearance variability and cognitive performance in a dual-task situation.
The data show that whereas reproductive decline is linked to increasing risks of mortality in chimpanzees , human reproductive senescence precedes somatic senescence.
The data so far point to a strong gene-environment interaction that determines the lung disease type.
The data source was semistructured interviews with @number@ family members of decedents who died @number@ to @number@ months prior to the study.
The data streams recorded by the DAS are uploaded to the data coordinating center for analysis.
The data substantiate the importance of the circumpubertal years for accruing bone mineral.
The data suggest a possible rationale behind the observation that aging blood products may increase the risk of complications following surgery and blood transfusion.
The data suggests that Drosophila CG31414 gene mutation might be useful for unraveling the molecular mechanism of Gaucher's disease.
The data suggests that PA monitoring can aid in evaluating clinical status.
The data suggest that aging impairs the ability to engage cognitive control effectively to prioritize what will be recollected.
The data suggest that both cortical and subcortical alterations may interact along the progression of MDD.
The data suggest that contraction in CSMC is dependent on cav-1 reorganization dynamics , which restores the physiological contractile response in aged CSMC.
The data suggest that INCENP in the CPC pathway contributes to ER-negative breast cancer susceptibility in the European population.
The data suggest that metazoan life span interventions may act through a common hormesis mechanism involving liver UPRmt , mitochondrial maintenance and sexual differentiation.
The data suggest that MM occurs in Drosophila and that the resultant misframed proteins accumulate with age.
The data suggest that osteogenic silica nanoparticles may be a safe and effective therapeutic for counteracting age-associated bone loss.
The data suggest that population differences in RMR may be due to genetic variants.
The data suggest that the MGE and CGE are the primary source of cortical interneurons.
The data suggest that the optimum activity of repair processes may favor longevity.
The data suggest that the relationship between human ageing and physiological function is highly individualistic and modified by inactivity.
The data support a favourable benefit-to-risk ratio for fesoterodine in elderly and medically complex vulnerable elderly patients with OAB.
The data support C allele as a protective factor for IVF pregnancy outcome.
The data support the conclusion that trospium chloride XR is safe and effective in patients with OAB taking multiple concomitant medications.
The data support the contention that side chain-oxidized oxysterols are strong suppressors of cholesterol biosynthesis under specific pathological conditions in humans.
The data support the idea that exercise may protect against aging.
The data survey can help us define national cancer management priorities.
The data themes suggest ways to develop male-specific messages and interventions that consider the aging body.
The data used for this study were derived from the epidemiological survey and were self-reported.
The data used in this study were from a nation-representative panel survey conducted in Taiwan from @number@ to @number@
The data was analysed using grounded theory.
The data was analyzed by standard contingency table and Poisson distribution methods after age justification.
The data was analyzed by using Pearson correlation test in SPSS version @number@
The data was collected from intraoral and radiological examinations and from a structured questionnaire.
The data was organized and analyzed using Alceste software.
The data were analysed after multiplanar image reconstruction.
The data were analysed applying Kvale's method of interpretive analysis.
The data were analysed by non-linear mixed-effect modelling with the use of a two-compartment structural model.
The data were analysed using mixed model anova to determine differences in the outcomes between the two groups.
The data were analysed using multilevel mixed-effects logistic and linear regression.
The data were analysed using non-linear regression modelling with a 1-phase exponential decay curve fit.
The data were analyzed according to two categories of maternal ages , < 30 yr and > or = 30 yr.
The data were analyzed at Qui-square and the association among the events was the odds ratio.
The data were analyzed for any minimum \ "safe distance. \ "
The data were analyzed for sleep apnea , diastolic heart sounds , and systolic time intervals.
The data were analyzed statistically using the univariate ANOVA test for comparisons between the groups before and after the intervention.
The data were analyzed using constant comparisons.
The data were analyzed using continuous methods to determine differences in variability between groups and between types of jump.
The data were analyzed using hierarchical regression analysis.
The data were analyzed using mixed ANOVA.
The data were analyzed using @number@ logistic regression models.
The data were analyzed using SPSS version @number@
The data were analyzed using storyboarding techniques and identifying critical turning points , culminating in a poetic transcription of the resulting narrative.
The data were analyzed using three-way ANOVA and the Tukey's test ( alpha = @number@ ) .
The data were analyzed using two-way ANOVA and Tukey HSD's post hoc test ( α = 0.05 ) .
The data were analyzed using univariable and multivariable logistic regression.
The data were analyzed with thematic content analysis.
The data were clustered to derive patterns of dietary intake.
The data were collated for common measurement instruments.
The data were collected by interviews that were analysed by qualitative content analysis as interplay between analysis , interpretation and meaning construction.
The data were collected by researchers in face-to-face interviews.
The data were collected during maximum-speed phase , and variability and symmetry indices were calculated from a total of @number@ steps.
The data were collected from @date@ to @date@ .
The data were collected from Peking University First Hospital and Anhui Chest Hospital between @date@ and @date@ .
The data were collected in 2011-2015 and analyzed in 2015-2016.
The data were collected in @number@
The data were collected through an interview and were analyzed using the technique of thematically analyze.
The data were collected using questionnaires to determine neglect and abuse experienced by both older people and caregivers , and the Zarit Burden Scale.
The data were compared using Mann-Whitney U , Fisher's exact and Student's t tests ( p < 0.05 ) .
The data were compared using three-way ANOVA.
The data were deployed to develop and evaluate a five-protein biomarker signature for colorectal cancer detection.
The data were evaluated in two groups : infertile patients @number@ years ( group @number@ ) and control @number@ years ( group @number@ ) .
The data were extracted by two independent observers.
The data were filtered and analysed using signal analysis methods in order to calculate PWV in the assessed retinal artery ( rPWV ) .
The data were fitted to a quadratic model.
The data were from four intervention and two observational studies with ages ranging 22-89 years.
The data were gathered from a survey , using face-to-face interviews.
The data were grouped by gender , blood group and / or genotype.
The data were merged to create consolidated themes.
The data were obtained from assessments found in the literature.
The data were obtained from functionally independent residents aged ≥65 years from @number@ municipalities in Japan ( n = @number@ ) .
The data were sorted into three themes : Cognitive Operations , Plasticity , and Mental Effort.
The data were sorted into three themes : Expectations , Self-Image , and Ways of Coping.
The data were statistically analyzed according to sex , age , and race.
The data were statistically analyzed , by means of ANOVA tests , Spearman correlation , t test , with significance level of @percent@.
The data were statistically analyzed using Student's t test and Wilcoxon-Mann-Whitney test.
The data were subjected to bi- and multivariate analysis.
The date of registration was @date@ .
The date of the first prescription fill was considered the index date.
The dates of data collection were 2005-2007.
The dates of the analysis were @date@ , to @date@ .
The date that the diagnosis of IBS had been made was the index date.
The daughters ' trabecular bone volume ( BV / TV ) , thickness , number , and separation predicted the corresponding traits in their mothers.
The DBA / 2J strain is a model for early-onset , progressive hearing loss in humans , as confirmed in the present study.
The DCD group was significantly less sensitive in detection of passive motion than TD children.
The D & CM intervention included a teamwork including nurses as care managers for the implementation of tailored care plans.
The DDR must be integrated with ongoing signaling and housekeeping processes.
The DDR to helix distorting covalent DNA modifications , including interstrand DNA crosslinks ( ICLs ) , is not as well defined.
The deacetylation ability of SIRT1 is important for controlling the function of several transcription factors , including nuclear factor kappa B ( NF-ĸB ) .
The deacylation activity of SIRT6 has been attributed to the regulation of TNF-α secretion.
The dead lice always appeared considerably shrunken due to drying.
The death of a child is one of the most traumatic events that a parent can experience.
The death rate increased significantly with increases in the FI , but women showed a lower death rate than did men.
The death rate significantly increased as biological age became larger than chronological age ( linear trend test , p value < @number@ ) .
The death risks seem to reach a plateau of around @percent@ at the age @number@ years for men and @number@ years for women.
The debilitating cognitive and behavioral symptoms characteristic of AD make it an extremely distressing illness for patients and carers.
The debilitating effects of muscle loss include declines in physical function and quality of life and increases in morbidity and mortality.
The decay of mRNA over time and under differing storage conditions was also assessed.
The decay of RRC is the substantive characteristic of aging , which gives a new understand of the redox theory of aging.
The deceased subjects were older and had lower ASM , handgrip strength , and walking velocity.
The decision is made by comparing two competing likelihood based models , the molecular clock ( MC ) and UPM.
The decision of SDD or not was on treating physician discretion.
The decision rule developed in this study may help to target early preventive measures against overweight in high-risk children.
The decision to have surgery involved clinical advice by doctors that the time had come to take up a surgical option.
The decisive cellular events at early stages of IPF are poorly understood.
The decline accelerated about @number@ years before clinical diagnosis.
The decline in AA's mental lexicon is discussed in light of the rates of declines in object naming ability reported in previous studies.
The decline in activity energy expenditure underlies a range of age-associated pathological conditions , neuromuscular and neurological impairments , disability , and mortality.
The decline in brown adipose tissue amount with increasing age may account for or aggravate middle-age obesity.
The decline in cognitive abilities is mainly due to reduced capacities in speed of information processing and working memory.
The decline in cognitive abilities over the course of the BD seems to be associated with the number of episodes and number of hospitalizations.
The decline in functional capacity is a heterogeneous phenomenon in the elderly.
The decline in functional capacity is unavoidable consequence of the process of aging.
The decline in LTP correlated with decreased expression of NMDAR subunits NR2A and NR2B.
The decline in purely subtractive surgical techniques in blepharoplasty surgery and the advent of fat repositioning and other volume enhancement techniques has improved surgical outcomes.
The decline in reserve groups defined by education ( p = @number@ ) and height ( p = @number@ ) was similar.
The decline in Sal-T with increasing age remained after adjustment for health-related factors.
The decline in sex hormone levels that accompanies the menopause has substantial effects on the tissues of the urogenital system , leading to atrophic changes.
The decline in sex hormones along with aging is suggested to be involved in age-associated diseases such as cardiovascular diseases , osteoporosis , and dementia.
The decline , known as sarcopenia , could lead to physical disability , poor quality of life , and death.
The decline of circulating androgens results from a combination of two events : reduced ovarian production and aged-related decline in adrenal androgen synthesis.
The decline of cognitive function has emerged as one of the greatest health threats of old age.
The decline of nephron number is accompanied by a comparable reduction in measured whole-kidney GFR.
The decline of tissue function in ageing is a consequence of many changes in the gene expression and other extrinsic factors.
The decline over time was similar for individuals with the late-onset and adult-onset phenotypes , but differed according to gender.
The declining fertility potential and the late age of motherhood are increasing significantly the number of patients over forty consulting infertility specialists.
The declining trend was reversed upon retirement , whereas the variance of sleep duration declined throughout the recording period.
The decomposition of the relaxivity signals enables the calculation of the CP capillary permeability ( K2 ) .
The decreased desire ( p < @number@ ) and frequency of nuts / almonds consumption ( p < @number@ ) were noted.
The decreased downtime of LF treatments made this the preferred choice of patients.
The decreased expression of p16 was partly due to GR-induced chromatin remodeling through effects on histone acetylation and methylation of the p16 promoter.
The decreased hydrophilicity of the modified dentin matrix likely influence the immediate mechanical properties of the hybrid layer.
The decreased reactive inhibitory control might result from speed-accuracy tradeoffs.
The decreased relaxation response to ISO and increased contractile response to ATP were also changed after administrating SQJN.
The decreased responses involve altered signaling events associated with the early steps of T cell activation.
The decrease in ACDG was significantly associated with deep initial ACDG and wide ACA.
The decrease in active MMP2 may be attributable to a similar reduction in the level of free pro-MMP2 , the precursor to the active form.
The decrease in ataxin-2 reduced aggregation of TDP-43 , markedly increased survival and improved motor function.
The decrease in Aβ deposition was associated with a reduction in the expression of BACE1 , the main enzyme responsible for Aβ generation.
The decrease in CRT was statistically significant in group @number@ ( P = 0.001 ) .
The decrease in damping properties and the increase in muscle-tendon unit stiffness suggest that postmenopausal women might be at a greater risk of injury.
The decrease in ovary cancer of urban areas tended to be restricted to women aged @number@ years and younger.
The decrease in response time in the yellow filter condition was larger when the stimuli were displayed peripherally in both groups.
The decrease in response times with more acoustic detail was stronger in the group of older participants.
The decrease in serum insulin-like growth factor-1 ( IGF-I ) with aging is related to the neurobiological processes in Alzheimer's disease.
The decrease in strength of those with active transfers over the 11-year period was within the reported aging loss for the normal population.
The decrease in testosterone levels is one of the causes , but the effect of estradiol is not well known.
The decrease in the number of blood vessels is statistically associated with that in the general number of fibroblasts and proliferating fibroblasts.
The decrease in the pupil response as a function of increasing SNR was relatively small for the listeners with hearing loss.
The decrease in total BDNF mRNA levels in these tauopathies was predominantly due to down-regulation of transcript IV.
The decrease of dissolved Cu concentrations was likely due to the dilution of rainwater.
The decrease of DMT1 levels at the apical membrane induced by iron was associated with decreased iron uptake rates.
The decrease of fast MHC and atrophy of muscle fiber with aging recapitulate observations in human VL muscle.
The decrease of free amino groups and of intrinsic fluorescence of tryptophan demonstrates HDL apoprotein modifications in HDL incubated with MG.
The decrease of SRB1 levels was a consequence of SRB1 / HNE adducts formation that leads to SRB1 ubiquitination and degradation.
The decrease of TCR diversity with aging has never been studied by direct methods.
The decreases in accuracy in target compared to nontarget trials were smaller in older compared to younger participants.
The decreases in apolipoprotein A-I and interleukin @number@ beta protein band densities were significant in the high molecular weight hyaluronic acid injection group.
The decrease was similar among men and women except for the items suffering from loneliness and feeling needed.
The deep cerebellar nuclei ( DCN ) are a key element of the cortico-cerebellar loop.
The deep fat compartments would appear to be more greatly subjected to age-related volumetric deflation.
The deep forehead compartments are in general avascular planes and permit blunt dissection for access to the supraorbital region.
The deep-plane midface lift offers many advantages in midface rejuvenation.
The default network of the human brain has drawn much attention due to its relevance to various brain disorders , cognition , and behavior.
The default network's functional architecture has been shown to change over the course of healthy and pathological aging.
The default system consists mainly of the medial prefrontal and medial parietal areas.
The defective expression of RACK1 may be dependent on age-related alteration of the balance between the adrenal hormones cortisol and dehydroepiandrosterone ( DHEA ) .
The defect size ranged from @number@ mm @date@ mm to @number@ mm @date@ mm after opening digital web-spaces.
The defects were more severe than observed in EDMD cells with mutations in a single gene.
The defense of a democratic and sustainable system reveals the importance of understanding how changes in healthcare take place.
The deficit accumulation-based frailty index ( FI ) can quantify health and its outcomes in aging.
The deficit could neither be explained by physiological aging nor by problems in earlier stages of auditory perception.
The deficit in brain metabolism was sustained thereafter.
The deficits in LTP were accompanied by changes in the expression and function of synaptic AMPARs.
The deficits were partially explained by greater complexity of older adults ' search paths.
The deficit was restored by transfection of wild type , but not BrS-related PKP2.
The defining feature is a kinetic tremor of the arms.
The definition includes a combination of universally accepted definitions of CKD and the main clinical manifestations of CKDnT.
The definition of a nursing home and the type of assistance provided in a nursing home is quite varied by country.
The definition of disease will incorporate genotype into what has historically been a phenotype-centric discipline.
The definition of ' elderly ' ranged from @number@ to @number@ years ; @number@ elderly and @number@ younger patients were included for analysis.
The definition of \ "gene \ " itself has become ambiguous , and the central dogma is continuously being revised and expanded.
The definition of IE was based on modified Duke criteria.
The definition of the action spectrum of the different drugs forms the basis for a defect-specific compensation strategy and a future personalized therapeutic approach.
The definition rightfully acknowledges the longitudinal dimension of SE , but its operationalization focuses solely on achieving value.
The definitions of normal and pathological aging are given.
The definitive mechanisms of high vulnerability in the elderly against pathogen threats are unclear.
The deformational load of the high-SMAS face lift caused only a @number@ percent creep in the tissue ex vivo.
The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease ( AD ) .
The degeneration of retinal ganglion cells and their axons results in an irreversible loss of vision and is correlated with increasing age.
The degeneration of retinal pigment epithelial cells ( RPE ) causes secondarily adverse effects on neural retina leading to visual loss.
The degradation disappears in obesity when JNK1 is inactivated in mice.
The degradation leads to inhibition of SIRT1 function , which contributes to development of hepatic steatosis.
The degradation of proteoglycans , which is another main ECM component in the IVD , however , has not been extensively investigated.
The degradation of the stitches and the number of ruptures increased with duration of implantation.
The degradation pathway is therefore a viable therapeutic target for future intervention.
The degree and distribution of the arterial wall enhancement on Gd-3DBB was assessed.
The degree of AAR increased with age.
The degree of aging was significantly reduced.
The degree of apathetic behavior was negatively associated with sport activity in female subjects and positively associated with TV watching in male subjects.
The degree of association between muscle mass and metabolic profiles was relatively very weak.
The degree of blood pressure elevation correlated positively with serum FGF-23 concentrations and inversely with Klotho levels.
The degree of calcification was assessed as @percent@ , @percent@ to @percent@ , @percent@ to @percent@ , @percent@ to @percent@ , and @percent@ to @percent@.
The degree of cell senescence was detected by aging cells in situ test kit.
The degree of cellular senescence , based on characteristic changes in cell morphology , is measured by laser scanning cytometry.
The degree of connectivity between different network nodes is described by the so-called link strength.
The degree of conversion ( DC ) was measured in real-time with Fourier transform infrared spectroscopy ( FTIR ) .
The degree of decrement in scores with age was stronger in the low education level group than in the high education level group.
The degree of degenerative changes was based on magnetic resonance imaging films.
The degree of dVRS was associated with the volume of white matter hyperintensities and the prevalence of lacunes , but not with brain atrophy.
The degree of galactosylation of IgG decreased with increasing age.
The degree of hearing loss ranged from mild to severe.
The degree of heterogeneity is unknown because accurate assessment is difficult using conventional proton magnetic resonance spectroscopy techniques in a beating heart.
The degree of hypertrophy during training is controlled in part through the activation of satellite cells and myonuclear accretion.
The degree of impairment in daily functioning is independently related to nutritional status.
The degree of increased peak compensation predicted executive dysfunction , while the degree of impaired pitch-response persistence predicted memory dysfunction , in AD patients.
The degree of knee pain was quantified by visual analogue scale ( VAS ) and Knee injury and Osteoarthritis Outcome Score ( KOOS ) Pain.
The degree of LTP-like effects induced by QPS5 was significantly smaller in the older group compared to the younger group.
The degree of mineralization and microstructure are regulated by bone turnover.
The degree of monomer conversion ( DC ) was measured using Fourier transform infrared ( FTIR ) spectroscopy.
The degree of neuronal inflammation and vasospasm was also compared.
The degree of pain measured @number@ ± @number@ points on average.
The degree of pigment reduction following combined therapy and QSNY alone was similar at @number@ weeks ' follow-up ( = @number@ ) .
The degree of reproductive impairment is dependent on chronologic age and the diagnosis or treatment.
The degree of restoration after cART was similar in both CD4 and CD4 NKT cells.
The degree of Rhythm deterioration was associated with the degree of airflow limitation , symptoms and frequency of exacerbations.
The degree of severity due to airbag-related UEI was generally minor.
The degree of systemic inflammation was not changed by ADAMTS-13 administration.
The degree of telomere shortening and c-FOS gene expression were measured in all specimens.
The degree of temporal changes of P25 and N35 in ULD was similar or even lower than that of healthy subjects.
The degree of the abnormal expansion of the CAG repeats governs the gradually diffuse atrophy of the brain.
The degree of VE was measured among @number@ participants without type @number@ or @number@ diabetes at baseline.
The degree of writing disability and personal , spatial , and temporal orientation was compared in these two groups.
The degree to which physicians discussed treatment-specifics with the patient moderated agreement-perception accuracy but not adherence-prediction accuracy.
The degree to which the association between HI ( T0-T2 ) and psychotic experiences at T4 was moderated by T0 urbanicity was examined.
The degree to which these changes are related to hyperglycemia remains unclear.
The degree to which these entities coexist and overlap is explored on high-resolution CT scans.
The degree to which this applies to elderly patients with hip fractures is unclear.
The DEGs were identified using LIMMA package among the three groups.
The deheterochromatinization T ( m ) was decreased by ~3-3.5°C compared with the T ( m ) observed for young individuals.
The delay predominantly occurred before transfer , as the patients had to wait for a bed to become available at the trauma centre.
The deleterious effect is mediated by mitochondrial reactive oxygen species , being abolished when the mitochondria electron transport is blocked.
The deleterious effect of ADF in rats suggests that additional studies of ADF effects on cardiovascular functions in humans are warranted.
The deleterious effects of reduced contrast and eccentricity were stronger in elderly individuals.
The deletion of p75NTR did not significantly change the cognitive function of the mice up to the age of @number@ months.
The delicate balance of pro- and antiinflammatory processes can lead to beneficial or detrimental effects to the failing heart.
The Delphi consensus panel survey of expert clinicians was a suitable method of developing such indicators.
The Delphi method was used to select standardized patient images confirming appropriate patient candidacy and overall surgical effect.
The Delphi process was conducted from April to @date@ .
The delta-lognormal model was used to obtain a detailed description of the velocity of these movements and of the neuromuscular synergy that produces them.
The demand for elective and emergency surgery by older patients is increasing.
The demand for facial rejuvenation and cosmetic procedures is rising among all ethnicities and skin types.
The demand for noninvasive and minimally invasive skin-tightening procedures is rising within the aesthetic world.
The demand for noninvasive methods of facial and body rejuvenation has experienced exponential growth over the last decade.
The demand for surgical correction of pelvic organ prolapse is expected to grow as the aging population remains active and focused on quality of life.
The demand for topical products capable of preventing aging or delivering cosmetic improvement to the male skin is growing.
The demands of physician practice are growing.
The dementia finding was unexpected , given consistent observational evidence that associates use of estrogen-containing hormone therapy with reduced risk of Alzheimer's disease.
The DEMMI test and the 30-s CST seem to be complementary to each other when evaluating functional changes in a geriatric hospital population.
The demographic and epidemiologic transition resulting from aging and the increase of life expectation means an increment related to chronic conditions.
The demographic and operative variables and postoperative medical and surgical complications were analyzed.
The demographic change in industrial countries leads to an increasing population that sustains an acetabular fracture in an advanced age.
The demographic data and clinical history were reviewed.
The demographic data and measurements were comparable between the two groups at baseline ( p > 0.05 ) .
The demographic data , stone parameters , stone-free rate , retreatment rate , and complication rate were analyzed in both elderly and non-elderly patient groups.
The demographic information with clinical parameters , procedure medication used and complications was noted.
The demographics , APOE [ Latin Small Letter Open E ] 4 status , and vascular risk factors were compared in the @number@ subgroups.
The demographics , clinical characteristics , and urodynamic recordings were reviewed.
The demographic shift towards an older population increases the public health burden.
The demographics of the world's population are changing , with many adults now surviving into their 80s.
The demonstration of preserved viewer-centered habitual attention in older adults suggests that it may be used to counter declines in controlled attention.
The DemTect® Polish language version proved to be independent of age and education level.
The DEM test should not be used to diagnose eye movement difficulties in a patient with poor reading ability.
The dendrimer-RSV formulation was successfully scaled up towards commercialization.
The de novo atherosclerotic lesion narrows the vessel lumen and causes stasis of blood flow in the distal stent.
The de novo lesion can also cause myocardial ischemia creating a prothrombotic environment in the stented region.
The densities of corneal endothelial cells and subbasal nerves were measured in both visits and compared with @number@ eyes of @number@ normal age-matched controls.
The densities were plotted against age and volume ratios.
The density of blood vessels in SAS-R tumors was higher than in SAS tumors.
The density of cholinergic fibers and terminals is modest as compared to other hypothalamic nuclei.
The density of female pelvic surgeons was highest in metropolitan areas.
The density of plaques showed a trend to increase , but only 6-CN-PiB-positive plaques reached significance in AD subjects.
The density of these deposits was increased in the molecular layer of the subiculum of AD compared to non-demented individuals.
The dental practitioner therefore needs to be familiar with the diagnosis and management of oral fungal infections.
The dental protrusion was verified when the overjet was larger than @number@ mm through periodontal probe in millimeters.
The dental skills necessary to treat these elderly are modifications of skills students routinely learn in dental school.
The dentin hydrophilicity significantly decreased after application of the priming solutions.
The Denver II Developmental Screening Test is a valuable test to detect early developmental delays , especially in infants with risk factors.
The dependence of cofilin binding on fractional saturation of actin filaments with drebrin suggests direct competition between these two proteins for F-actin binding.
The dependence of lesion volume upon age , sex , coronary artery disease , and the severity of AS were tested.
The dependency on DDR markers of DSB detection tools has left questions unanswered.
The dependent measure was the relative attention paid to the faces on each slide.
The dependent variable of the study was the Life Satisfaction Scale.
The dependent variable quantified facility-level multiracial diversity.
The dependent variables included the age-specific prevalence of decreased testosterone and the probability of TDS-specific symptoms.
The dependent variable was the number of physician visits in the past @number@ months.
The dependent variable was treatment response.
The dependent variable was whether the respondent ate together more or less than once a month.
The depigmentation can appear after only a few treatment sessions , and can cause much disfigurement , especially in cases with background melasma.
The depletion effects were most pronounced for the old-old , suggesting that increased age may be associated with decline in attentional resources.
The depletion of SMP30 caused an elevation of NF-κB-responsive inflammatory markers.
The depletion of SMP30 increased redox-related PTK / PTP imbalance and PP1 / PP2A inactivation.
The deposited ECM was exposed by removing BCE.
The deposition of aluminum when using Shofu abrasives and nickel in Intensiv was demonstrated.
The deposition of AβpN3 increased in accordance with the number of SP , but that of N-terminally intact Aβ ( AβN1 ) did not.
The depressed group included @number@ elderly , depressed subjects with high comorbid apathy and @number@ with low apathy.
The depressed participants were more often abstinent and less often moderate drinkers than the nondepressed participants ; they did not differ in at-risk drinking.
The Depression and Somatic Symptom Scale ( DSSS ) was also used to evaluate somatic symptoms in the subjects.
The Depression Residual Symptom Scale ( DRSS ) and Montgomery-Åsberg Depression Rating Scale ( MADRS ) were administrated to evaluate depressive symptoms.
The depressive state was further evaluated using simultaneous semi-structured interviews.
The depth of our knowledge regarding mast cells has widened exponentially in the last @number@ years.
The depth of thermal delivery was adjusted before each pass and all subjects received a minimum of two to three passes to the treated areas.
The depth of the vein was measured vertically from the outer border of the retinal pigment epithelium to the outer vein wall.
The depth of t-m transformation slightly increased to @number@ µm.
The deregulated nonoxidative pentose phosphate pathway ( PPP ) is known to promote oncogenesis , but the molecular mechanism remains unknown.
The deregulation of B cell differentiation has been shown to contribute to autoimmune disorders , hematological cancers , and aging.
The derivation of physiological markers or new approaches to detection and treatment of disease-related entities associated with the risk factor aging are desirable.
The derived formula shows that the concentration of water in each tissue type can be modeled as a negative exponential function of age.
The derived relation of the new TPG is expressed in terms of clinically available surrogate variables ( anatomical and hemodynamic data ) .
The dermal elastic fibre network imbues skin with the capacity to recoil and loss of this property contributes to an aged , wrinkled appearance.
The dermal filler portfolio available in Europe is exponentially larger than that in the US.
The dermal filler Princess VOLUME is a highly cross-linked , viscoelastic hyaluronic acid injectable gel implant used for aesthetic treatment.
The dermatologic issues of this aging population are strongly influenced by many social , economic , and cultural factors.
The DERs were developmentally conserved across @number@ brain regions and in the developing mouse cortex , and were expressed in diverse cell and tissue types.
The DERs were further enriched for active chromatin marks and clinical risk for neurodevelopmental disorders such as schizophrenia.
The descending control system of bipedal upright posture and gait may have a functional link to cognitive domains.
The description of the specific aspects of PLMS in children was also carefully reported , with important clues on their evaluation in this age group.
The descriptive microanatomy was corroborated by morphometry.
The design allowed participants to monitor time by checking a clock whenever they decided.
The design of the partial retainer could affect the clinical performance of these restorations.
The designs are intended to provide robust evidence on risk , natural history , and underpinning neurobiology and outcomes relevant to aging populations.
The desire for minimally invasive facial rejuvenation has continued to increase from the perspective of both the patients and injectors.
The desire of many to look young for their age has led to the establishment of a large cosmetics industry.
The destabilizing mutation A546T in the corneal protein TGFBIp leads to lattice-type corneal dystrophy , but symptoms only appear in the fourth decade of life.
The destruction induced by the ANHCPS on bacterial surface structure was proven by using SEM technique.
The detailed mechanism for reactive oxygen species ( ROS ) generation in infected cells remains elusive.
The detection limit of the PCR products with the proposed method was @number@ ng on the membrane.
The detection of NIs in skin biopsies is useful for an antemortem diagnosis.
The detection of P. aeruginosa was significantly associated with RP even after adjusting for chronic pulmonary diseases ( aHR = @number@ ) .
The detection of the fall is done on the basis of accelerometric data and depth maps.
The detection rate at the femoral neck was similar to the overall detection rate.
The detection rate of B. dentium was higher in the elderly than in other ages.
The detection rate of causative bacteria in ICT consultation was @percent@ ( @number@ out of @number@ patients ) .
The detection time was measured for each trial.
The deteriorating ability to communicate has a negative impact on quality of life in the aging population.
The deterioration in the ability to do housework is a potentially important indicator of evolving cognitive impairment in some old people.
The deterioration of bone mineral density and lean body mass , leading to osteoporosis and sarcopenia , respectively , are age-related processes.
The deterioration of sleep in the older population is a prevalent feature that contributes to a decrease in quality of life.
The determinants identified in this review depicted the stage progression of the trans-theoretical model ( TTM ) in explaining an individual's readiness to hearing-aid usage.
The determinants of in-hospital death were hemodialysis and congestive heart failure.
The determinants of malnutrition were explored and the relationships between nutritional status and unhealthy lifestyle factors were examined.
The determinants of telomere attrition , a potential marker of cellular aging , are not well understood.
The determination of the vitamin A value of plant foods rich in provitamin A is important but has challenges.
The detrimental associations were stronger in women with BMI < 30 kg / m2.
The detrimental consequences of vitamin D dietary deficiency have been documented in other neurodegenerative diseases.
The detrimental effects of aortic stiffening may result in brain damage as well as heart failure.
The detrimental effects of chronically elevated glucose levels on bone should be added to the more well-known complications of diabetes.
The detrimental effects of vascular risk factors on white matter microstructure were exacerbated among APOE ε4 carriers.
The developed method has excellent potential as individualized biomarkers in the detection of pathophysiological changes in early-stage AD.
The developed model was used to evaluate the cost-effectiveness for sacubitril / valsartan at different per diem prices.
The developed model was validated with published experimental data for elderly exposure to transient and steady hot and cold environments.
The developed protocol could be applied to characterization of other enzymes / proteins and other types of unconventional posttranslational protein modification.
The developed score was associated strongly with the presence of advanced neoplasms.
The developed software analyzes the fiber skeleton to obtain intersections , fiber orientation , concentration , porosity , diameter distribution , segment length and tortuosity.
The developing collagen fragments are further degraded by MMPs @number@ and @number@
The developing lamination appeared the most distinguishable at the parieto-occipital part of brain and peripheral regions of the hippocampus.
The developmental differences identified across age groups between @number@ to @number@ years for a sample of @number@ children support a multistage interpretation of EF development.
The Developmental Eye Movement ( DEM ) test was developed on the assumption that poor eye movement control is a major cause of reading difficulties.
The developmental origins of brown adipose depots as well as transcription factors involved in their differentiation have recently been described.
The developmental regulation of globin gene expression has shaped research efforts to establish therapeutic modalities for individuals affected with sickle cell disease and β-thalassemia.
The developmental task of finding integrity and avoiding despair showed to be a significant mediator in this relationship.
The development and daily use of tools for rapid assessment of autonomy should enable practitioners to innovate and thus , adapt their management.
The development and detailed analysis of animal models of TDP-43 proteinopathies are critical for understanding the pathogenesis of these disorders.
The development and implementation of feasible , effective PA programs for older adults with multiple comorbidities are warranted.
The development and implementation of the NIS provided considerations for program practicality.
The development and maintenance of mitochondrial heteroplasmy has important consequences for both health and heredity.
The development and physiological aging of teeth provide many clues for estimating age , in methods that are mainly based on conventional radiography.
The development and understanding of interventions to reduce concerns about falling are therefore relevant.
The development dataset comprised @number@ @number@ men ; the validation dataset comprised @number@ men.
The development of a cataract becomes highly likely from the sixth decade of life onward.
The development of accurate diagnostic tests and treatment of dementia must be important issues in an aging society.
The development of a Center for Advanced Practice was explored and implemented.
The development of a CF-specific approach to the diagnosis and treatment of NTM infection is a research priority for the CF community.
The development of age-related cataract ( ARC ) is associated with DNA damage of the lens epithelial cells ( LECs ) .
The development of AMD-like retinopathy in OXYS rats is also accompanied by increased accumulation of Aβ in the retina.
The development of a model to complement the physician's experience in specifying therapeutic regimens is therefore desirable.
The development of animal models to study human frailty is important to test interventions to be translated to the clinical practice.
The development of associative memory during childhood may be influenced by metacognitive factors.
The development of a unified conceptual framework for the field of biogerontology has been impeded by confusing and misleading terminology.
The development of BCIs for use by this population may begin with studies in HVs but also needs to include studies in people with ALS.
The development of biological markers ( biomarkers ) pertaining to disease is a rapidly growing area within this field of medicine.
The development of colonic diverticulosis is a common aging change in industrialized nations.
The development of computational approaches is , however , challenged by a wide spectrum of aging mechanisms participating on different levels of biological organization.
The development of educational disparities in health was tracked across the three waves.
The development of empathy and positive attitudes are essential elements of professional education.
The development of fractional photothermolysis is a milestone in the history of laser technology and cutaneous resurfacing.
The development of gastric adenocarcinoma is a complex multistep process involving multiple genetic alterations.
The development of HCC is a multistep process which includes the progressive alterations of gene expression leading to the increased proliferation and to liver cancer.
The development of hepatoblastoma ( HBL ) is associated with failure of hepatic stem cells ( HSC ) to differentiate into hepatocytes.
The development of information and communication technologies for design of environments for ageing is of great importance considering demographic trends in the future.
The development of interventions to reduce oxidative stress is hampered by the absence of sensitive detection methods that can be used in live animals.
The development of in vivo ultrasensitive magnetic resonance imaging ( MRI ) and two-photon laser-scanning microscopy has revolutionized our understanding of neuroinflammation.
The development of LA is not associated with the use of metformin , but with the severity of the pre-existing disease.
The development of LV remodeling after primary percutaneous coronary intervention is associated with increased mortality and with shorter event-free survival.
The development of medical interventions for the preservation of disease-free longevity would be facilitated by markers that predict healthy aging.
The development of mobility disability , an early event in the disablement process , precedes and predicts more severe forms of inability.
The development of narrow-gauge transconjunctival vitrectomy systems has improved the rate of visual recovery following surgery.
The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier.
The development of new UI was defined as participant report of inability to control voiding at discharge.
The development of nursing interventions to improve positive attitudes towards old age and self-efficacy is essential for enhancing health-promoting behaviours.
The development of palliative care in China is vital to the care of its aging population and associated increase in cancer incidence.
The development of presbycusis , or age-related hearing loss , is determined by a combination of genetic and environmental factors.
The development of public health interventions could help reduce co-existing physical and mental health problems , especially during late middle-age.
The development of reward-related neural systems , from adolescence through adulthood , has received much recent attention in the developmental neuroimaging literature.
The development of sensitive measures to assess subtle functional decline poses a major challenge for characterizing functional limitations in MCI.
The development of sensitivity to radial optic flow discrimination was investigated by measuring motion coherence thresholds ( MCTs ) in school-aged children at two speeds.
The development of shadows and shadow patterns are the fundamental changes that occur with volumetric facial aging.
The development of SIRT7 modulators may allow new therapeutic strategies that control tumor progression by reprogramming the chromatin landscape and biosynthetic machinery of cancer cells.
The development of such inequalities across childhood ; however , has not been studied using longitudinal data.
The development of symptoms after valproate onset is unpredictable , and severity of symptoms is unrelated to plasma levels.
The development of the disease-concept is historically different between cervical spinal stenosis and lumbar spinal stenosis.
The development of the next generation of soft hydrogel biomaterials focuses on facile synthetic methods , efficacy of treatment , and tunable multi-functionalities for applications.
The development of visual function takes place over many months or years in primate infants.
The deviation is characterized by mechanism of adaptation to the insufficient energy production in CNS.
The deviation of an individual's AMH level from the modeled value showed a reasonable intra-individual correlation.
The device consists of two leaflets and a sealing component made from bovine pericardium , supported by a self-expanding wireframe made from superelastic NiTi alloy.
The DHEA plasma concentrations decreased with age in subjects with DS as well as in controls.
The DHEA plasma concentrations of @number@ adults with DS and @number@ age-matched controls were determined.
The diabetes risk variant rs864745 within JAZF1 was associated with arteriolosclerosis ( OR = @number@ p = @number@ ) .
The diagnoses were not mutually exclusive.
The diagnosis and follow-up of these alterations allow professionals and caregivers to consider adaptations of the patient's environment according to their needs.
The diagnosis and management of TB in these circumstances is often challenging.
The diagnosis and treatment of DED are often difficult due to the discordance between symptoms and signs of the disease.
The diagnosis based on clinical criteria was used as reference standard , as it was the best available reference despite its known limitations.
The diagnosis can be easily mistaken for other neurodegenerative diseases , which are often accompanied by inflammation and the production of cytokines.
The diagnosis followed to Brown diagnostic system.
The diagnosis is also challenging due to the lack of a definitive serum total testosterone level that reliably correlates with symptoms.
The diagnosis is clinical and there is no treatment for it but recognition is necessary to minimize early atherosclerosis through the control of dyslipidemia.
The diagnosis is complex and requires the integration of information obtained by clinical , laboratory testing , imaging and muscle biopsy.
The diagnosis is oriented to clinical and histomorphological criteria which will be critically reviewed.
The diagnosis of AD was based on NINCDS-ADRDA criteria.
The diagnosis of age-related cataract diagnosis might alert doctors to some systemic disorders on the whole body level.
The diagnosis of Alzheimer's disease can be improved by the use of biological measures.
The diagnosis of COPD is primarily based on the physiological documentation of airflow limitation using spirometry.
The diagnosis of dementia was based on DSM-IV criteria and the probable and possible AD on the NINCDS-ADRDA criteria.
The diagnosis of dry eye was referred to the well-accepted domestic diagnostic criteria The SPSS11.
The diagnosis of ED , associated or not with late onset hypogonadism , is mostly clinical.
The diagnosis of epilepsy in old age is particularly challenging and is often overlooked or missed.
The diagnosis of IBS usually depends primarily on established clinical criteria.
The diagnosis of infection was reached when it was classified as certain or possible by an expert panel.
The diagnosis of interatrial blocks ( IABs ) is easy to perform using the surface ECG.
The diagnosis of MCI was made according to Petersen's criteria.
The diagnosis of menopause is established by the absence of menstruation for @number@ months or more.
The diagnosis of mild cognitive impairment ( MCI ) entails evidence of objective cognitive loss using neuropsychological measures.
The diagnosis of non-convulsive status epilepticus is difficult in the elderly because possible aetiologies of confusion may present with the same clinical picture.
The diagnosis of PD was also confirmed by SPECT with DATSCAN , after CT-brain exclusion of potential other causes of the symptoms.
The diagnosis of PML is based on clinical , neuroradiological , pathological , and molecular analyses.
The diagnosis of PTTI is largely a clinical one.
The diagnosis of sarcopenia relies in part on normative data on muscle mass , but these data are lacking.
The diagnosis of sarcopenia should be considered in all older patients who present with observed declines in physical function , strength , or overall health.
The diagnosis of UC was confirmed by a combination of laboratory examination , colonoscopy , and histological assay.
The diagnosis relies on clinical signs and the peculiar metabolic triad of hyperammonemia , hyperornithinemia , and urinary excretion of homocitrulline.
The diagnosis was established by coronary artery angiography.
The diagnostic accuracy and discriminatory ability of the ACE-R were examined via receiver operating characteristic ( ROC ) analysis.
The diagnostic accuracy is sufficiently high for this technique to be clinically useful in distinguishing DLB from AD , especially in patients with mild dementia.
The diagnostic algorithm should lead to verification of nocturia and identifying its cause because treatment of nocturia differs remarkably according to the etiology.
The diagnostic approach to anemia in the elderly is the same as in younger individual.
The diagnostic criteria for LOH varied.
The diagnostic criteria of LOH were adapted according to European male aging study , @number@
The diagnostic power of AMH in predicting spontaneous pregnancy was evaluated by receiver operating characteristic ( ROC ) curves.
The diagnostic test had @percent@ sensitivity , @percent@ specificity , and area under the curve receiver operating characteristic of @percent@.
The diagnostic use of GDF-15 will be also useful in a forthcoming MA-5 clinical trial.
The diagnostic value of echocardiography in diagnosis is operator-dependent and its sensitivity can decrease in presence of intracardiac devices and valvular prosthesis.
The diagnostic value of predictors was judged using multivariate logistic modeling and area under the receiver operating characteristic curves ( ROC area ) .
The Diag-Sympt group displayed the highest \ "difficulty in adhering to treatments. \ "
The diameter as well as the depth of the IJV increased with the age and weight of the patient.
The diary data were analyzed using Daily Life software program.
The Dicer oscillations were either reduced or phase shifted with aging and Type @number@ diabetes.
The Dice similarity scores were as high as @number@ for subcutaneous fat and @number@ for visceral fat.
The diet and several of its components have additionally been shown to have beneficial effects on the co-morbidities typical of elderly populations.
The dietary arachidonic acid content of both diets was constant at approximately 0·4 % total fatty acids.
The dietary intake of diet score components was associated with BMI , which was associated with blood pressure and total cholesterol.
The DIET group were asked to follow a Mediterranean type diet for @number@ weeks whereas the CON group were asked to follow their normal diet.
The diets of @number@ 3-6 y old children attending low-income day-care centers serving either @number@ or a single meal were examined.
The diets were administered continuously for @number@ weeks when six fresh skin samples from each group were assembled and subjected to extraction of protein.
The diets were assessed on the basis of qualitative meal classification method of Bieliiska and Kulesza.
The diet was also assessed separately by meal time.
The difference between accelerometer-measured weekday and weekend sedentary time was nonsignificant.
The difference between attempted reach and actual maximal reach provided a measure of judgment error.
The difference between biological age and actual chronological age would indicate an individual's level of aging.
The difference between cortisol responders and nonresponders was equivalent to approximately @number@ years in aging.
The difference between DNA methylation age and chronological age ( Δage ) was calculated in four longitudinal cohorts of older people.
The difference between energy level scores ( @number@ to @number@ ) felt by respondents in the evening and morning defines the chronotype score and classification.
The difference between groups was statistically significant.
The difference between iTUG and aTUG ( Δ TUG ) was calculated.
The difference between neuroanatomical age and chronological age was compared between the three groups.
The difference between protein served and consumed was also significant ( p = .04 ) .
The difference between the groups achieved statistical significance ( p < @number@ ) .
The difference between the mean perceived age for the @number@ evaluators and the chronological age was only @number@ years ( < 10 months ) .
The difference between the negative control group and the activated group was analyzed using student's t test.
The difference between the numbers of days to AMD documentation for all three services was not statistically significant.
The difference between these two measures ( PQ1 - PQ2 ) was designated DΔ.
The difference between the two was the same for the two groups.
The difference between Walkers and Non-Walkers was greater in men.
The difference between younger and older adults ' rates of learning depended in part on initial WMC.
The difference compared to placebo in systolic or diastolic BP was not clinically or statistically significant.
The difference , however , was only statistically significant for the presence of superficial marginal discoloration ( McNemar , p = 0.01 ) .
The difference in AD was not evident when the sample was stratified by educational level.
The difference in agreement between the FTF-FTF and OL-FTF groups was @percent@ , indicating that there was no difference between the methods of assessment.
The difference in BMI between subjects with good and poor sleep quality was non-significant.
The difference in complete clearance rates ( imiquimod minus vehicle ) was @percent@ and @percent@ , respectively.
The difference in disease-specific mortality rates between groups A and B was significant ( p < @number@ ) .
The difference in echogenicity between the upper and the lower ROIs of the oldest group showed a positive correlation with the Rmax.
The difference in gray matter density between homotopic coordinates was used as a regressor to reduce the effect of structural asymmetries on functional lateralization.
The difference in involvement between live-in and nonlive-in caregivers could be the foundation to tailor more specific interventions.
The difference in knowledge scores between the study groups was not significant.
The difference in level of agreement between the professions was assessed using the weighted least-squares approach for comparing correlated kappa of Barnhart et al.
The difference in mg / l between the 5th and 95th percentile was @number@ @number@ and @number@ for these age groups.
The difference in mortality between those who died versus survivors was assessed by means of Fishers Exact Test.
The difference in oral LD bioavailability between the groups may result from a difference in excretion ability.
The difference in ORs from the GEE and the matched case-control analysis was statistically significant ( p = @number@ ) .
The difference in physical HRQL between HIV-positive and HIV-negative individuals did not become greater with a higher number of comorbidities or with higher age.
The difference in prevalence of multimorbidity between the two cohorts was more pronounced among women.
The difference in the risk of falls was not significant ( relative risk @number@ @percent@ confidence interval [ CI ] @number@.94-1.75 ) .
The difference in the wavelet coherence of the elderly subjects and the young subjects indicates an altered cerebral autoregulation caused by aging.
The difference of plasma vWF level between male and female were analyzed by independent sample t test.
The difference of systolic BP ( SBP ) between two ankles was calculated as DETASBP.
The difference of the trend between temporal vertical lines was significant as well ( P < @number@ ) .
The difference of WPCO in response to posture change between the elderly and the young subjects indicates an altered CA due to aging.
The difference remained statistically significant after adjustment for cardiovascular risk factors ( P = @number@.2×10 ( @number@ ) ) .
The differences between pathways and age groups were quantified and interpreted in context of the test-retest repeatability of the measurements.
The differences between PIMs use according to Beers criteria @number@ and @number@ were calculated using chi-squared and McNemar's tests.
The differences between the self-assessment of quality of life of older people living in institutional care in the hospital and outside the hospital are discussed.
The differences between these techniques and the information they capture about swallowing have not previously been explored in a direct comparison.
The differences between young and elderly ONH fibre alignment within regions suggest that age-related microstructural changes occur within the structure.
The differences depend on the diagnostic age of the affected relative.
The difference showed statistical significance ( χ ( @number@ ) = @number@ P < @number@ ) .
The difference showed statistical significance ( χ ( @number@ ) = @number@ P < @number@ H = @number@ P < @number@ ) .
The differences in aetiology , clinical diagnosis and treatment of cemental tears are described and discussed in order to provide guidance for clinical practice.
The differences in depressive symptoms between married and widowed elderly people could be explained by the inverse of the level of family support.
The differences in healthcare utilization between the groups remained significant after adjusting for comorbidity levels , lifestyle factors , and attending primary care.
The differences in LV volumes and EF between the software packages were small.
The differences in mean scores between fallers at baseline ( n = 113 ) and non-fallers were statistical analyzed.
The differences in mortality rates and APC effects between regions are related to demographic differences and access of health services across the country.
The differences in regulation can be distinguished by new techniques of cardiovascular physics.
The differences in the average contents of Ca and P by age group were observed between the left coronary arteries of men and women.
The differences in the calculated and reported rates negatively affected quality rankings for the plans that most accurately reported rates.
The differences in the genetic regulation of inflammatory processes may influence the presence of age-related disorders.
The differences in the higher frequency range suggest the main disturbance to be connected with the spinal reflexes.
The differences in the mechanisms of FoxO activation by antioxidants and oxidants result in differences in FoxO phosphorylation and target gene expression.
The differences observed between school-aged children and adults could also potentially impact clinical decision analysis.
The differences observed between young and older adults were independent of whether ID was manipulated via target size or movement distance.
The differences observed in the outcomes of both approaches are due to the probabilistic character of ABMS contrasted to SDMS.
The differences remained largely unchanged after adjusting for income and tended to be accentuated when the threshold period was extended.
The differences were significant for both the TMH ( p = @number@ ) and the TMA ( p = @number@ ) .
The difference was not related to age , sex , level of education or informant.
The difference was smallest in Italy ( @number@ and @number@ years among men and women , respectively ) .
The difference was statistically significant ( p < @number@ × 10-9 ) .
The difference was statistically significant ( χ ( @number@ ) = @number@ @number@ @number@ respectively , P < @number@ ) .
The difference was statistically significant ( χ ( @number@ ) = @number@ P = @number@ ) .
The different aetiopathogeneses and distinct molecular events involved in tau aggregation have led to the development of various animal models for these diseases.
The different age-related alteration patterns of the global and regional network metrics between aMCI patients and healthy controls were assessed by a linear regression model.
The different behavioral strategies available for mammal species to cope with both decreased and increased levels of ambient temperature are reviewed.
The different clinical phenotypes in the two siblings support the absence of an obvious genotype-phenotype correlation in Cockayne syndrome type A patients.
The different clusters were related to specific kinematic parameters that can be assessed in routine clinical practice.
The different forms of mycosis usually have been described as mutually exclusive , independent entities , with few descriptions of overlapping cases.
The differential diagnosis , neuroimaging , and pathological findings are discussed , as well as their public health implications.
The differential diagnosis of hyponatremia should include plasma osmolality , which can be increased , normal or decreased.
The differential effects of dual tasks and dual-task training on postural stability still remain unclear.
The differential impact of ageing and cytomegalovirus ( CMV ) latent infection on human T-cell subsets remains to some extent controversial.
The differential laminar pattern was validated through postmortem examination.
The differentially expressed proteins were associated with diverse cellular processes including amino acid metabolism , RNA processing and protein metabolism , and DNA synthesis.
The differentially methylated genes were found on various autosomes , with no enrichment on chromosome @number@
The differentially methylated regions in mice have high sequence conservation in humans and the pattern of methylation is also largely conserved between the two species.
The differential results between older males and females suggest that certain gender-specific mechanisms may affect the association between adiponectin and age-related body composition changes.
The differential role of these polymorphisms appears at early stages of treatment rather than in the final antidepressant outcome.
The differential value for P300 latency in the krill oil group was significantly lower than that in the medium-chain triglyceride group at week @number@
The differentiated muscle cells , the multinucleated contractile myofibers , are terminally withdrawn from mitosis.
The differentiation potential of hTMSCs was evaluated in osteogenic media by histology and determination of osteoblastic gene expression.
The different polishing protocols did not affect the wear to the antagonist ( P > .05 ) .
The different products proved to be equivalent in response rate and effectiveness with no significant difference after @number@ weeks and @number@ months in statistical analysis.
The different QT correction equations provided similar results , except the Bazett equation.
The difficulties of assessing the symptoms of late-onset hypogonadism are highlighted.
The difficulties of establishing best practices due to methodological challenges and implications for further research are presented.
The difficulty in capitalizing on synthetically lethal interactions in cancer cells is that many potential targets do not possess well-defined small-molecule binding determinates.
The difficulty in performing precise and uniform human studies is mostly responsible for the inconsistent outcomes reported in the literature.
The difficulty now is in maintaining the nationwide commitment to these preventive measures.
The difficulty of detecting Salmonella in sprouts , whether using LAMP or qPCR , warrants further study.
The diffusion metrics from multiple subjects and sessions at each site were aligned to their common white matter skeleton using tract-based spatial statistics.
The digital nature of next-generation sequencing has revealed clonal heterogeneity in the majority of AML at diagnosis.
The Digit Symbol-Coding and Information subtests from the Wechsler Adult Intelligence scale were used to measure the @number@ cognitive domains at each assessment.
The DII was calculated from food intakes assessed using 24-h dietary recalls and expressed per @number@ calories consumed.
The dimension of the head and pinnae in the chinchilla as well as the acoustical properties associated with them are mature by ~6 weeks.
The dimensions of the incisive foramen and incisive canal , and anterior maxillary bone thickness demonstrated gender differences with males showing greater values.
The dimensions of these devices vary from @number@ to @number@ mm in diameter and @number@ to @number@ μm in thickness.
The diminishment of contractility is exerted via MAP kinase pathway , and involves reduction of c-fos gene expression and of transcription factor AP-1 protein expression.
The DIOP surface was then modified using a silane coupling agent , ( KH570 ) , to reinforce interfacial adhesion.
The dipeptide is not only found in skeletal muscle , but also in other excitable tissues.
The direct and indirect cost of brain disorders exceeds EUR @number@ billion a year.
The direct application has several drawbacks and its performance has not been evaluated.
The Direct Assessment of Functional Status-Revised ( DAFS-R ) provided a performance-based assessment of IADLs.
The direct correlation between higher FGF-23 level and higher VLM is most pronounced in hypertensive patients.
The directed osteogenic and chondrogenic differentiation of line SC6-MSC has shown.
The direct effect of age represented @percent@ of the total effect in @number@ and decreased to @percent@ in @number@
The directionality , magnitude , and progression of these associations remain unclear.
The direction and course of the canals were assessed.
The direction and severity of herniation and the presence of myelopathy was determined for spinal levels C2 to C7.
The direction and size of some of these effects were different for cognitively impaired versus cognitively intact residents.
The direction in which the items were formulated was just as important as what was being measured.
The direction of the effect was consistent across both the better and worse ears.
The direction of treatment-induced change of abnormal brain responses can distinguish these two possibilities and shed light on the therapeutic mechanism.
The directions of the effects varied depending on the performance measure in question though.
The direct phosphorylation of human synaptojanin-1 by R1441C hLRRK2 could further be confirmed by in vitro kinase assays.
The direct repair of DNA damage by endogenous repair enzymes lessens rates of mutagenesis and strengthens the immune response to tumor cells.
The disability , mortality and costs caused by osteoporosis-induced nonvertebral fractures are enormous.
The disabling effect decreased over time for stroke ( p trend = @number@ ) and multiple cardiometabolic diseases ( p trend = @number@ ) .
The disabling impact of visual loss was significant for @number@ of the @number@ activities , when analyzed one by one.
The disadvantage of this co-location is exposure of mtDNA to mutagenic ROS ( reactive oxygen species ) , which are by-products of aerobic respiration.
The Discharge Abstract Database and National Rehabilitation Reporting System were used.
The discharge management was significantly different in comparison to patients under the age of @number@ with respect to avoidance of discharge at the weekend.
The disciplines of cardiology and oncology have increasingly recognized the benefits to patients of collaborating in the care of cancer patients with cardiac disease.
The discoloration increased with aging time toward yellowness ; however , it was not perceptible in all test groups after @number@ days.
The discordance between bone quantity and skeletal fragility has driven investigation into additional determinants of fracture resistance in T2DM.
The discovery and characterization at the molecular level of its novel components has increased our understanding of how t-PMET regulates distinct cellular functions.
The discovery of cell surface GRP78 , in cancer cells and cells undergoing ER stress , presents a novel therapeutic strategy.
The discovery of epidermal stem cells in the HF has given new life to the search for a cure for baldness.
The discovery of extracellular microRNAs ( miRNAs ) in CSF raises the possibility that miRNA may serve as novel biomarkers of AD.
The discovery of heat stress cognate @number@ secretion , in normal and cancer cells undergoing stress , presents novel therapeutic strategies.
The discovery of induced pluripotent stem cells ( iPSCs ) has the potential to revolutionize the field of regenerative medicine.
The discovery of olfactory receptors by Axel and Buck sparked greater understanding of the molecular basis of olfaction.
The discovery of small molecules that specifically inhibit EZH2 raises the exciting possibility of exploiting the oncogenic addiction of tumor cells toward this protein.
The discovery of various GFAP splice variants gave an additional boost to explore this protein in more detail.
The discovery that mutations in these RBPs can cause familial motoneuron diseases and familial dementias indicates the importance of these genes to neuronal degeneration.
The discovery that the retina is another CNS tissue synthesizing neurosteroids , among which neuroactive steroids , has favored these studies.
The discreet temporal access and the MUST dissector allowed a safe dissection of anatomical tissue planes to perform safely a mid-face and eyebrow lift.
The discrepancy was assessed using the individual difference score and the residuals for each domain of DEMQOL.
The discrepant TH01-longevity association results in Germans and Italians could therefore be due to population-specific effects.
The discrete variables were peak joint net moments and ROM in sagittal plane in knee and ankle.
The discriminant analysis showed that for the pooled sample , @percent@ of the cases were correctly classified into the respective age group.
The discriminant value was @number@ @number@ and the resolution was @percent@.
The discrimination ability and the reproducibility of μ ( PA ) have been compared with other traditional ANS indices.
The discrimination ability and the reproducibility were evaluated by Cohen's d between young and elderly groups and by the interclass correlation coefficient , respectively.
The discrimination power of mE-PASS was assessed by the area under the receiver operating characteristic curve ( AUC ) .
The discrimination results are examined and discussed within the context of multiple-look mechanisms and possible age-related differences in the sensory coding of signal onsets.
The discriminative ability of the basic model was high ; the extended model did not enhance predictive ability.
The discriminative accuracy of the Hachinski ischemic score for dementia subtypes in atrial fibrillation is poor , with a significant proportion of misclassifications.
The discussed system is intended for evoked muscle training of the anterior and posterior thigh.
The discussion focuses on the role of desirable difficulty during encoding in producing the benefits of lag , spacing , and testing.
The discussion focuses on the roles of recollection and familiarity in supporting associative memory as well as implications for the remediation of age-related memory decline.
The discussion focuses on understanding women's sexual relationships and behaviors within the context of their cohort and lives.
The discussion is divided into @number@ sections.
The discussion provides a means to better understand functional connectivity and its application to typical and atypical brain function.
The disease combination malignancies and movement disorders multimorbidity also appeared to significantly affect cognition.
The disease duration ranged from @number@ week to @number@ years ( median , @number@ weeks ) .
The disease duration varied from @number@ days to @number@ days ( @number@ days on average ) .
The disease duration was from @number@ months to @number@ years.
The disease has several subtypes which defer slightly in the clinical characteristics , immunological markers , population distribution and the suitable treatments.
The disease involves widespread synaptic loss in the neocortex and the hippocampus.
The disease is characterized by intracellular neurofibrillary tangles and extracellular amyloid fibrils composed of amyloid beta peptides ( Abeta ) .
The disease is further characterized by the tendency to extensively spread beyond normal fascial and connective tissue planes.
The disease is highly associated with age , and becoming increasingly prevalent in our aging societies.
The disease is prevalent in Europe and the United States , which has a large number of individuals of European descent.
The disease is prevalent in Finland only and is not commonly included in the differential diagnosis of ALS.
The disease often is normally difficult to diagnose due to its broad range of characters without specific symptoms.
The disease prevalence was @percent@ in males versus @percent@ in females , yet this difference was not statistically significant ( P = @number@ ) .
The disease progresses relentlessly , leading to dystonia , chorea , motor disability and neuropsychiatry features.
The disease-risk allele was also associated with up-regulated humoral immunity through increased levels of soluble BAFF , B lymphocytes , and immunoglobulins.
The diseases associated with robust genes seem to be relatively lethal like cancer and aging.
The disease severity was estimated at admission and at day @number@ using model for end-stage disease and discriminant function index scores.
The disease-specific reductions were significant for admissions for cancer and diabetes , but not for cardiovascular disease.
The disease-state of age-related cognitive decline-Alzheimer's disease and other dementias-hijacks our consciousness and intellectual autonomy.
The disease typically occurs in elderly patients and has a highly variable clinical course.
The disinhibitory process , referred to as \ "priming \ " , involves presynaptic GABA autoreceptors that inhibit GABA release.
The dislocation of β-catenin appeared to reflect synaptic disorganization.
The dispersions were characterized by zeta potential , light scattering techniques , optical and transmission electron microscopy , encapsulation efficiency and in vitro drug release.
The displacement of brain tissue under conditions representing the onset of hydrocephalus are then calculated.
The displacement of the centre of pressure ( COP ) is a measure that has been successfully employed in studies regarding the postural control.
The displacement of the COP was collected for each subject standing on a force plate.
The disproportionate distribution was highest for older asylum seekers and children < 7 years.
The disproportion of degenerative change in joints of the upper cervical spine might also contribute to the high frequency of type II odontoid fracture.
The dissociation between the startle reaction and myoclonus was suspected to be another feature of V180I CJD.
The distalization forces applied were @number@ N in group @number@ and @number@ N in groups @number@ and @number@
The distal radius fractures ( DRFs ) are the second most common fracture in the elderly population.
The distal radius is assembled with a thin cortex formed by fusion ( corticalization ) of trabeculae arising from the periphery of the growth plate.
The distance between the segments was measured using retinal photographs.
The distance from the mirror was increased until they no longer held fixation.
The distance map resulting from the second method showed a relative volume loss in the intermetacarpal spaces of the average old hand.
The DistEn had relatively lower sensitivity to the predetermined parameters and showed stability even for quantifying the complexity of extremely short series.
The DistEn took full advantage of the inherent information underlying the vector-to-vector distances in the state space by probability density estimation.
The distinct effects of salience and relevance suggest that they had different statuses in attentional processing of manoeuvring drivers.
The distinct features of these specific microbial communities might affect human health and disease.
The distinctive merit of metaproteomics on health state monitoring will be given special attention.
The distinctive properties of transformed cells suggest that treatment with such materials will have a deleterious rather than a protective effect on such abnormal cells.
The distinct regional distribution of WM atrophy reflected the topography of gray matter ( GM ) loss.
The distinct sites of collagen cleavage generated by collagenases and cathepsin K in healthy and OA human femoral condylar cartilages were identified and compared.
The distortion in temporal organization is thought to be related to a number of serious health problems and promote neurodegeneration.
The distractor effect was similar in both groups.
The distribution and number of CD68-positive KC and CD83-positive DC reflect the progression of liver fibrosis leading to liver failure.
The distribution by gender was @percent@ male and @percent@ female , and the mean age was @number@ years.
The distribution characteristics of basic syndromes were analyzed using SPSS @number@
The distribution of age showed biphasic peaks-in the tens to twenties , and sixties to seventies.
The distribution of a population throughout the physiological age of the individuals is very relevant information in population studies.
The distribution of baseline characteristics among individuals with or without MRIs was not different.
The distribution of CFS scores was similar irrespective of AF status.
The distribution of corneodesmosome remnants was analysed by corneodesmosin distribution with immunocytochemical corneocyte labelling.
The distribution of immune-labelled corneodesmosome remnants and the corneocyte projected area showed a correlation between age and structural maturation.
The distribution of lesions may overlap in MS and NMO although the immunoreactivity of AQP4 differs in these @number@ conditions.
The distribution of metabolites between the left and right auditory cortex was also determined.
The distribution of p53 overexpression was coincident with that of pathological alteration , such as neuronal loss , calcification and atrophy.
The distribution of refractive astigmatism showed a two-peak distribution with high astigmatism for with-the-rule and against-the-rule astigmatism.
The distribution of responses on the SCREEN II-AB nutritional risk instrument is reported.
The distribution of rheumatologists is mainly in the large cities , particularly in the smaller countries.
The distribution of rs11171806 genotype was also investigated in subgroups according to the age and gender.
The distribution of SNs along lumbar spine and their relationship with age and gender were examined by single factor analysis of variance chi-square test.
The distribution of SS may predict the probable underlying cause.
The distribution of stage , differentiation grade , and extent of venous invasion were similar.
The distribution of the amount of corneocyte removal with adhesive tape increased with age.
The distribution of the CD83-positive DC in the sinusoidal and the periportal spaces was not even.
The distribution of the different strategies also differed significantly between groups.
The distribution of these morbidities was similar in the two genotype groups.
The distribution of these pathological hallmarks throughout the brain is not random ; it follows a predictive pattern that is used for pathological staging.
The distribution of the visits for these diagnoses across @number@ specialties was assessed.
The distribution of transdiscal and transosseous injuries was almost equal ( 13 / 10 ) .
The distributions of scores for these measures were the primary outcomes.
The distributions of the FIs were skewed with long right tails.
The distributions of the population over the age of @number@ and life expectancy are significantly affected by both contemporaneous and historical GDPpc at provincial level.
The disturbance of brain Ca ( 2 + ) homeostasis may play a pivotal role in the revelation of brain disease.
The disturbances in ERK signaling in Nup107 depleted cells closely mirror the similar changes in senescent cells.
The disynaptic reciprocal inhibition and D1 inhibition and International Cooperative Ataxia Rating Scale ( ICARS ) scores were evaluated in both groups after @number@ weeks.
The diuretic amiloride potentiated the human GABA-A ρ1 GABA-mediated current , whereas GMQ antagonized the receptor.
The diurnal variation in positive affect was greater in participants < 65 years compared with older individuals.
The divergent mortality risks for visceral fat and subcutaneous fat in women suggest complex relationships between overall fatness and mortality.
The diverse functions of the cerebellum make it an important structure to investigate in aging.
The diversity in rates of aging observed in nature suggests that the rate at which age-specific selection weakens is determined by species-specific ecological factors.
The diversity of bacterial communities in aged pit mud was higher than that in aging pit mud.
The diversity of etiological factors and electrophysiological mechanisms promoting AF in humans hampers the development of more effective therapy of AF.
The diversity of this population in terms of life expectancy , treatment tolerance , function , disability , and social support mandates personalized treatment plans.
The division in quartiles of ages showed an underestimation of GFR only in the first quartile of age ( < @number@ years old ) .
The DLK1 ( PREF1 ) status of human ASC is however unknown.
The DM-by-FPG group had higher systolic and diastolic blood pressure , fasting serum insulin , and HOMA-IR.
The DM-by-HbA1c group had significantly older age , higher proportion of women , and lower hemoglobin concentration.
The DM epidemic poses huge public health challenges for China and India.
The DMFT scores ( DT , MT , FT ) were recorded.
The DMN-DAN anti-correlation was numerically but not significantly lower in aMCI compared to HC.
The DNA damage and repair pathway might be an effective target to delay the onset of ARC.
The DNA damage response ( DDR ) arrests cell cycle progression until DNA lesions , like DNA double-strand breaks ( DSBs ) , are repaired.
The DNA damage sensors ATM and ATR linked to the subnetwork associated with senescence.
The DNA damage signaling pathway was also regulated with anthocyanins.
The DNA methylation analysis was limited to @number@ individuals with both imaging and brain methylation data.
The DNA-PK complex also functions in both DNA double strand break repair and telomere maintenance.
The DNA repair protein Cockayne syndrome group B ( CSB ) has been recently identified as a promising anticancer target.
The DNA / RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines.
The DNase I footprint revealed the protein-binding core sequence through which the protein binds the ATEE.
The DNAs were extracted from the samples stored at room temperature after @number@ weeks.
The dogma until recently was that cell differentiation was largely fixed unless exposed to the environment of an activated oocyte.
The domain regarding cognition and social function appeared to be less sensitive than the upper and lower extremity skills domains to increasing age.
The domestic asthma clinical guideline have no significant effect on ICS prescription , especially in primary clinics.
The domestic living arrangements were assessed by a single item with five options : ' With whom are you living together ? '
The dominance of type E damage accelerates cuticle loss.
The DONE framework was created by an interdisciplinary workgroup in a multiphase , multimethod process.
The donor sites were sutured directly.
The dopamine metabolite @number@ , ( DOPAL ) is detoxified mainly by aldehyde dehydrogenase ( ALDH ) .
The dopaminergic system is modulated by a number of other different factors.
The dopamine transporter ( DAT ) and the enzyme ( COMT ) both terminate synaptic dopamine action.
The dorsolateral pFC ( DLPFC ) is a key region for working memory.
The dorsomedial hypothalamus ( DMH ) controls a number of essential physiological responses.
The dorsum of the other hand of each subject was injected with saline solution and used as a control.
The dosage of BoNTA should be less than @number@ U during treatment in China with lowered incidence of complications.
The dosage of paroxetine was the average dose per day in each week.
The dose and regimen were at the discretion of the treating oncologist.
The dose-duration effect was significant in @number@ terms and by time.
The dose of a drug varies from patient to patient and individual adjustment of the dose is always ideal but is not always practical.
The dose of radiation and contrast volume were not different between the two approaches.
The dose range was 40-160 mg oxycodone hydrochloride equivalent per day.
The dose-response relationships were assessed by using generalized least-squares trend estimation.
The dose-response relationship was assessed by a restricted cubic spline model.
The Dosett® consistently rated better across all criteria.
The dose was adjusted to achieve testosterone levels between @number@ and @number@ ng / dL.
The DPE is an index of inter-trial inhibition to keep attention away from previewed , non-target information.
The DPPH and ABTS radical scavenging activities of GEB at @number@ and @number@ mg / mL approximately ranged between @percent@ and @percent@.
The draft guidelines were written by a multidisciplinary expert panel ; they were then revised , based on comments by expert organisations.
The dramatic increase in smartphone usage has spurred the development of many health-related mobile applications ( apps ) .
The dream of slowing down the aging process has always inspired mankind.
The DRI , based on the interRAI CHA , fills this void.
The Drinking Motives Questionnaire measures motives for alcohol consumption on four subscales.
The driving and socialization behaviors were videotaped for @number@ minutes per session ( @number@ session per week ) within the same period.
The driving patterns of older adults are influenced not only by their health and socioeconomic backgrounds , but also by state relicensing policies.
The drop in HbA1c was correlated with insulin-associated weight gain.
The drug-dependent induction of premature senescence in neoplastic cells is considered per se an important tumor suppressive mechanism.
The drug-related anticholinergic burden was estimated by the Anticholinergic Risk Scale ( ARS ) .
The drug-related mortality rate did not decline with age.
The drugs appear able to reduce the age-dependent increase in Ca ( 2 + ) transients and the Ca ( 2 + ) -sensitive afterhyperpolarization.
The drugs selected were : amitriptyline , cimetidine , diazepam , digoxin , fluoxetine , methyldopa , nifedipine , promethazine , thioridazine and ferrous sulfate.
The dry , amine-terminated product can be obtained from bulk silicon wafers in less than @number@ h.
The DS and multidomain cognitive outcomes were measured annually for an average follow-up of @number@ years.
The DTI maps are typically analyzed by region-of-interest or voxel-based analytic techniques such as tract-based spatial statistics.
The DTS's negative likelihood ratio was @number@ ( @percent@ CI @number@ to @number@ ) for both raters.
The DTS was @percent@ sensitive ( @percent@ CI @percent@ to @percent@ ) , with an expected specificity of approximately @percent@ for both raters.
The dual mechanisms of control account posited two qualitatively different cognitive control mechanisms ( Braver , Gray , & Burgess , @number@ ) .
The dual role of cell senescence in chronic liver disease will make this an intriguing but challenging area for future clinical interventions.
The dual-task paradigm has previously been used to investigate the attentional demands associated with postural control.
The dual-task situation thus greatly reduced the demands of stimulus categorization while still requiring two response selections and two response executions.
The Duke Activity Status Index was completed , and the greatest distance from @number@ ISWTs was recorded.
The durability and efficacy of each treatment were assessed by microscopy and staining.
The durability of resin-ceramic adhesion varied , depending on the adhesive cement type.
The duration and quality of life in elderly patients with CHF also depend on accompanying diseases.
The duration of caregiving was < 5 years in @percent@ of the participants , while its mean was @number@.2±2.5 years.
The duration of exposure correlated positively with the frequency of MN ( r = @number@ P = @number@ ) .
The duration of follow-up was @number@ years.
The duration of hospitalization was @number@ + / - @number@ days.
The duration of hospital stay was significantly shorter in the patients in Group-1 compared to those in Group-2 ( p = @number@ ) .
The duration of hypertension significantly influenced on the severity of cognitive impairment in patients of middle and old age.
The duration of LOH treatment was not fixed and was established individually by both the patient and treating physician.
The duration of mTOR treatment for SEGAs might have to be prolonged , probably lifelong , because SEGAs usually grow back after treatment is stopped.
The duration of proximal esophageal contractions was longer in group I than in groups II and III ( P < 0.001 ) .
The duration of shoulder pain showed a moderately negative correlation with PMBF values ( n = @number@ ) .
The duration of single saccades depends on age to a smaller extent and does not change in patients with Parkinson's disease.
The duration of the illness and the extent of radiographic changes were also taken into consideration.
The duration of their intimate relationship was on average @number@ years ( SD = @number@ minimum = @number@ maximum = @number@ ) .
The duration of the primary submovement tended to be longer for the aged groups , although significance was reached only for the elderly group.
The duration of treatment was @number@ days.
The durations of mechanical ventilation and hospital stay , and rates of bloodstream infection and mortality , were also comparable between the @number@ groups.
The Dutch population of first generation Turkish and Moroccan migrants is ageing.
The Dutch Society of Cosmetic Medicine advises against the use of polyalkylimide.
The dwelling check contributed most to the awareness of and interest in possible alterations for aging-in-place.
The ' dwelling check ' was developed as a ' basic ' check on the possibility for aging-in-place.
The dynamic and multi-position radiographic observation was conducted.
The dynamic balance of mitochondrial fission and fusion can be studied in terms of antagonistic subpopulations that regulate the mitochondrial responses in space and time.
The dynamic mechanical analysis ( DMA ) results showed that the storage and loss moduli increased with increasing the HA ratio and the testing frequency.
The dynamic nature of the framework allows it to evolve as experts can continually add new determinants and ratings.
The dynamic nature of these processes motivates mathematical modelling and the simulation of such complex process.
The dynamic properties of aging processes deserve particular attention.
The dynamics of accumulation , photo-oxidation , and photodegradation of bisretinoids during aging or in the presence of pathology have been insufficiently investigated.
The dynamics of aortic growth throughout life are greater in women than in men.
The dynamics of B cell clonal evolution during affinity maturation has significant importance in infectious and autoimmune diseases , malignancies and aging.
The dynamics of performance in professional sport requires a systematic improvement of the training process.
The dynamics of the decline was different between males and females.
The dynamics of the mean and variance of the population age resulting from the two proposed formulations are obtained.
The dynamic strength , the isometric peak , and rate of torque development for the lower limbs were assessed before and after interventions.
The dynamism proved non-homogenous with a visible gender difference.
The dysexecutive subgroup had a history of hypertension less frequently compared with the amnestic subgroup.
The dysfunctions of adaptive B and T cells are well documented , but the effect of aging on innate immunity remains incompletely understood.
The dyslipidemic subjects were characterized with higher intake of energy , fat , and saturated fatty acids ( SFA ) .
The dysphagia-screening tool was redesigned on the basis of frontline clinician feedback , clinical guidelines , user satisfaction , and multidisciplinary expertise.
The dysregulation of mitochondrial function has been implicated in the pathogenesis of Parkinson disease.
The dysregulation of MT in these systems is likely to have tissue-specific effects on aging outcomes.
The dysregulation of Wnt signaling has been implicated in age-associated diseases , such as cancer and some neurodegenerative conditions.
The E47 mRNA stability is decreased in old B cells due to decreased phospho-MAPKinase and phospho-TTP ( tristetraprolin ) .
The e4 allele confers risks of neurological disorders in men and women ( RR = 1.98 , p = 0.046 ) .
The ɛ4 allele of Apolipoprotein E ( ApoEɛ4 ) was the only known major risk factor for late onset AD.
The E50K optineurin transgenic mouse described here exhibited clinical features of POAG and may be useful for mechanistic dissection of POAG and therapeutic development.
The e-ageing modules developed in this project have been evaluated positively by users.
The EA meta-analysis results were highly consistent with CHS-only results.
The earlier the menopause , the more severe and complex the impact on sexuality is.
The earlier the osteoporosis is diagnosed , the more quickly people can take action to stop bone deterioration.
The earliest pathological symptom observed by HE staining in the cerebral cortex is spongiform change.
The early cognitive diagnosis of stroke patients could be useful by helping physicians to identify those at a high risk of developing PSCI.
The early damage in anatomical connectivity and progressive loss of synapses that characterize early Alzheimer's disease suggest that MCI could also be a disconnection syndrome.
The early decline in LH to @percent@ of baseline was not different in older vs. younger PMW.
The early detection and diagnosis of AD and other age-related neurodegenerative diseases , however , remain a challenging scientific frontier.
The early diagnosis of necrotizing fasciitis can be difficult.
The early extubation strategies applied in the @number@ centers were successful in the majority of cases.
The early identification of a frail status is essential for preventing loss of functional capacity , and its clinical consequences.
The early identification of DCI by noninvasive imaging modalities would provide valuable information of therapeutic intervention for improving the patient outcomes.
The early identification of elderly patients more prone to physical decline represents a crucial step for establishing preventive measures.
The early identification of elevated Hcy will offer a window of opportunity for the primary prevention of CVD and metabolic syndrome.
The early life environment can be crucial in influencing the development of an animal's long-term physiology.
The early sign of subclinical atherosclerosis presented as an intima media thickness in the carotid may indicate endothelium dysfunction.
The earth's average global temperature is slowly but consistently increasing , and along with mean temperature changes come increases in heat wave frequency and severity.
The ease of set-up lends itself to replication and testing in clinical and cost-effectiveness studies.
The easiness of accomplishment of forced oscillation measurements was greater than that of spirometry.
The Eastern Cooperative Oncology Group performance status was ≥2 in @number@ ( @percent@ ) .
The Eastern region is estimated to grow by @percent@ over the lifetime of the projections at the expense of most other regions.
The easy access to massive WJ amount makes it an attractive source of MSCs for cell-based therapies.
The EBR was recorded under resting conditions , using two gold skin electrodes above and below the left eye.
The EC50 values of action potential duration and action potential duration at @percent@ of repolarization were @number@ and @number@.3nM respectively.
The ECG entropy value and HF value decreased at > or = @number@ years old with statistically significant.
The ECM components including collagen , elastin , and fibrillin-1 and that of signaling molecules ( SIRTs ) were determined from each passage of cells.
The EC ( @number@ ) value of aged garlic extract for the superoxide radical scavenging effect was @number@ mg / ml.
The economic burden of colorectal cancer is likely to increase over time owing to its current trend and aging population.
The economic burden of incident and previous fragility fractures was estimated at CHF @number@ million for the same year.
The economic burden of incident and prior fragility fractures was estimated at < euro > @number@ billion.
The economic burden of incident and prior fragility fractures was estimated at € @number@ billion.
The economic consequences of applying the accelerated 1-h algorithm are unknown.
The economic costs related to presenteeism exceed those of absenteeism and employer health costs.
The economic evaluation will examine the incremental costs and benefits generated by using the Otago Exercise Program intervention versus the control.
The economic impact of cardio-cerebrovascular disease in EU alone is more than EUR @number@ billion , while tumors have an impact of EUR @number@ billion.
The economic impact of osteoporotic fractures is large and growing.
The economic implications of these treatment regimens have not been explored.
The economic inequity causes difference in aging process , which deserves for future interventions.
The economic value of delayed aging is estimated to be $ 7.1 trillion over fifty years.
The ECO-VR demonstrated feasibility for cognitive assessment in older adults , as well as content and construct validity evidences.
The ectodomain of Klotho is cleaved and secreted into the urine to regulate several ion channels and transporters.
The ectopic expression of p31S6K1 in wild-type 3T3-L1 cells resulted in adipogenesis differentiation defects , showing that p31S6K1 is an inhibitor of adipogenesis.
The ED01 records and our earlier research are available @url@
The edges lost due to AD tended to connect nodes in the temporal lobe to other lobes or nodes within or between the latter lobes.
The ED LoS , RU , and accuracy of the 1-h algorithm was compared to that achieved by the SoC at ED discharge.
The ED ( @number@ ) for glutamic acid and the @number@ established excitotoxins was 200- to 360-fold lower , varying from @number@ to @number@ μM.
The EDSS @number@ score was independently predicted by an older age at onset , as a continuous variable after @number@ years of age.
The EDT group was also required to answer cognitively challenging questions while doing beginner-level square-stepping exercise ( i.e. , dual-task training ) .
The educational goal of the study was to expose undergraduate students to qualitative research methods , having them analyze transcripts and audio recordings.
The educational level and economic status of CHILILAB people in @number@ have improved.
The education and income differences did not change significantly over time for most policies and in most countries.
The Education in Palliative and End-of-Life Care ( EPEC ) Program has been one model of training clinicians in primary palliative care skills.
The education issues include a lack of qualified faculty and clinical sites to allow for more students to be accepted into the programs.
The education mission of the Department of Veterans Affairs ( VA ) is to train health professionals to benefit VA and the United States.
The education of recurrent fallers and their care givers is required in order to implement appropriate intervention.
The EEG findings after the TBI are highly predictive.
The EEG signal is the best window we have on cortical brain activity and provides a fair pharmacodynamic feedback of the effects of hypnotics.
The EEG study consisted of at least one awake and one nap-sleep video-EEG recordings and evaluation of other EEGs performed elsewhere.
The EEGs were visually assessed for the presence of focal and / or diffuse abnormalities.
The EE paradigm has been proposed as a non-invasive treatment for alleviating age-related memory impairment and neurodegenerative diseases.
The effect for mortality , but not for disability , was independent of sociodemographic and psychosocial factors.
The effect is small but clinically relevant in the interpretation of inner retinal layer thickness measurements.
The effective dose ( ED ) was calculated using age-specific correction factors.
The effectiveness and risk of surgical treatment , chemotherapy , radiotherapy and combination therapy for elderly patients with esophageal cancer will also become important.
The effectiveness of approved antidementia drugs , however , is limited-licensed AD medications provide only moderate relief of clinical symptoms.
The effectiveness of current influenza vaccines in the elderly population is often diminished by immune senescence.
The effectiveness of nutritional interventions to prevent and maintain cognitive functioning in older adults has been gaining interest due to global population ageing.
The effectiveness of the health care providers ' treatment was associated with the cause of sickness absence.
The effectiveness of the programme has more impact on children than adolescents ( P < 0·05 ) .
The effectiveness of the proposed approach was demonstrated by applying it to detect the SWS of @number@ subjects.
The effectiveness of the recruitment strategies and the feasibility of recruiting APOE e4 carriers are discussed.
The effectiveness of the training on increasing the participants ' knowledge of and confidence in using IM was explored.
The effectiveness was similar.
The effective number of tests was calculated using the Genetic Type I Error Calculator.
The effective reflecting length was significantly and positively associated with the difference between central and peripheral pulse wave velocities ( r = 0.76 ) .
The effect of 17β-estradiol on ethanol-induced BBB disruption and change / or increase of iNOS activity , which modulate BBB integrity , were evaluated.
The effect of 2-3 births on lifespan may be associated with delayed cellular aging.
The effect of 8-Br-cAMP or VPA may in part be due to the up-regulation of cytokine-related and inflammatory pathways.
The effect of acute limb heating on dilator function within the atherosclerotic prone vasculature of the lower limbs of aged adults is unknown.
The effect of age and gender was modeled with forward / backward selection using a regression model.
The effect of age and menopause status on drug pharmacokinetics is evaluated.
The effect of age , gender , and refractive error on various ONH parameters were also studied.
The effect of ageing on hyperthermia-induced changes in cardiac function is unknown.
The effect of ageing on hyperthermia-induced changes in cardiac function is unknown.
The effect of age in the compensatory treatment of HVFD , however , has never been investigated hitherto.
The effect of age must take into account when evaluate the LV function by the twist-displacement loop.
The effect of age on cerebral metabolic rates for acetoacetate in gray matter did not reach significance ( p = @number@ ) .
The effect of age on frontal lobe related cognitive functions of depressed patients , however , has not been adequately studied.
The effect of age on prevalence of PCO was assessed.
The effect of age on rate-adaptation dynamics of the QT interval is less well understood.
The effect of age on the clearance ( CL ) of therapeutic proteins has not been explored extensively in pediatric subjects.
The effect of age on trace element contents in intact prostate of @number@ apparently healthy 13-60 years old men was investigated by neutron activation analysis.
The effect of age , sex , ethnicity , and diabetes status on SIF420 [ kx0.5 , km0.5 ] was analyzed.
The effect of AGEs on cell viability of primary lung fibrotic fibroblasts and alveolar epithelial cells was assessed.
The effect of age was independent of the contrast of the peripheral target or distractors.
The effect of aging is substantial.
The effect of aging of gel formulations for 3months in refrigerator was investigated.
The effect of aging on brain asymmetry was studied under consideration of possible confounding effects of known age-related decline in higher cognitive functioning.
The effect of aging on hippocampus is often confounded by diseases that commonly occur in the elderly.
The effect of aging on the main features of corneal epithelium , sub-basal nerve plexus , stroma , and endothelium was investigated.
The effect of aging on these brain-behavior relationships was also of interest.
The effect of aging was minimal for all Zirconia implants.
The effect of aging was seen as delayed anticipatory muscle activity and larger compensatory muscle responses in older adults as compared to young adults.
The effect of aging was tested in a sample of @number@ healthy male subjects ( 20-58 years old ) during eyes open condition.
The effect of androgen-deprivation therapy on the ST segment was also evaluated in @number@ prostate cancer patients ( Study @number@ ) .
The effect of anthocyanins on epithelial-mesenchymal transition ( EMT ) has not been extensively studied.
The effect of ARE on cell viabilities of several tumor cells was estimated by MTT assay.
The effect of Casp12 on NF-κB activation was indicated via the post-translational degradation of IκB.
The effect of computerised imagery-based cognitive bias modification on positive affect , vividness of positive prospective imagery and interpretation biases in older adults was measured.
The effect of contemporary social changes on informal care in aging migrant communities is poorly understood.
The effect of continuous visual flow on the ability to regain and maintain postural orientation was examined.
The effect of contrast interacted with the temporal sampling rate.
The effect of CR on endometrial receptivity was determined by an in vitro adhesion assay between JAr cells and CR-induced Ishikawa cells.
The effect of culturing conditions on efficiency of BM-MMSC expansion was determined.
The effect of daily ingestion of collagen hydrolysate ( CH ) on skin extracellular matrix proteins was investigated.
The effect of decreased O-GlcNAc on the maintenance of normal β-cell function , however , is not well understood.
The effect of deformation rate was not modulated by the treatment either , indicating no effect on viscosity.
The effect of depression was even higher on post-dexamethasone cortisol levels ( @number@ ) , whereas it was non-significant on morning ACTH and CRH levels.
The effect of diabetes with and without insulin use on the rate of first fall-related injury hospitalization was assessed using proportional hazards models.
The effect of different types of exercise on central mechanisms such as temporal summation of pain ( TSP ) is less clear.
The effect of early therapeutic intervention on LTL in HIV and HCV infections should be evaluated.
The effect of excess intramyocardial fat on cardiac function in nonobese individuals is unknown.
The effect of exercise in IBM continues to be investigated.
The effect of fats on longevity has traditionally been disregarded as purely detrimental.
The effect of female gender was @number@ ( @number@ @number@ ) .
The effect of fish , vegetables , fruits , and alcohol needs further investigation.
The effect of gender in the non-disability group , mostly composed of older persons , is limited.
The effect of genetic / early-life factors is also unknown.
The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer.
The effect of healthy aging on cognitive control of irrelevant visual information was investigated by using event-related potentials.
The effect of HFD is present even without effects on insulin sensitivity and intramyocellular lipid accumulation.
The effect of higher levels of glucose and insulin on muscle mass has not been studied in individuals without diabetes.
The effect of HIV on immune function in aging is relatively unknown.
The effect of immersion in the field for about @number@ months was insignificant for As concentration on the surfaces.
The effect of immune diffusible mediators on synaptic plasticity might result in CNS dysfunction during neuroinflammatory brain diseases.
The effect of increased intensity on the acoustic and perceptual parameters was assessed.
The effect of insulin under high-glucose conditions was associated with reduced reactive oxygen species and increased nitric oxide ( NO ) .
The effect of interventions aimed at surgery-related falls should focus on the first @number@ days after surgery and differentiate between the causes of falling.
The effect of low grade inflammation was markedly weaker and affected only iFGF23 levels.
The effect of low testosterone concentration on aortic stiffness is more prominent in young men and in subjects with higher blood pressure levels.
The effect of low vitamin D levels in children with bone fragility disorders has not been examined in detail.
The effect of LS is complex and may be mediated or confounded by health and functional status.
The effect of marital status , income , and employment on insurance coverage differed by age and gender.
The effect of MCI on total decision-making was equivalent to the effect of more than @number@ additional years of age.
The effect of miR-21 on chondrogenesis was also investigated in a chondrocyte cell line.
The effect of miR-21 on the expression of growth differentiation factor @number@ ( GDF-5 ) was further assessed by luciferase reporter assay and western blot.
The effect of multimorbidity and its interaction with dementia status was studied using individual growth models.
The effect of NANOG on contractile function was sustained for about @number@ days after termination of its expression.
The effect of obesity and aging was ascertained with general linear models.
The effect of obesity on the incidence of hypertension is stronger in women than in men.
The effect of octreotide on cell growth was tested on Caco-2 cell line.
The effect of older age on CD4 count changes was insignificant ( p-trend = 0.06 ) .
The effect of older age on time to first treatment modification was insignificant ( p-trend = 0.21 ) .
The effect of other sleep-disturbing conditions on atrial fibrillation progression is not known.
The effect of pain catastrophizing on pain interference was strongest in adolescents and relatively weak in all @number@ other groups.
The effect of perioperative prophylactics , such as steroids and sivelestat , was not confirmed in this study.
The effect of pharmaceutical therapies for sarcopenia can be enhanced by this comprehensive approach.
The effect of phylloquinone supplementation ( @number@ μg / d ) for @number@ y on plasma ucMGP was determined among @number@ participants.
The effect of pre-diabetes and T2DM on bone macroarchitecture and strength has not been well investigated.
The effect of PRP on the proliferation of chondrocytes was performed using cell counting and WST8 proliferation assays.
The effect of Rab1A expression on multiple cancer-associated signaling pathways was also examined.
The effect of RAS blockers on soluble Klotho in patients with diabetic kidney disease ( DKD ) is unknown.
The effect of reactive oxygen species generated by the functional activity of cells , i.e. apoptosis and mitotic cycle , is shown.
The effect of reward on performance accuracy and speed was not related to age , indicating that all subjects could perform the task correctly.
The effect of risk factors on cord blood titres was investigated.
The effect of sarcopenia on cognition is related to low muscle strength rather than low muscle mass.
The effect of sex hormones , either endogenous or through hormonal replacement therapy , might be the most plausible explanation for the observed patterns.
The effect of short and long sleep duration on mortality was highest among young individuals and decreased with increasing age.
The effect of single variants and the combined effect of variants were calculated.
The effect of SIRT1 inhibition by siRNA on chondrocyte gene expression was examined by real-time PCR and Western blotting.
The effect of smoking was assessed using appropriate statistical tests.
The effect of speed on foot and ankle kinematics was assessed by comparing results during slow walking and fast walking.
The effect of such practices has been investigated in previous imaging studies but limited to cerebral neural activity.
The effect of the adhesive system was significant for microtensile and macroshear ( p < @number@ ) but not for macrotensile.
The effect of the association between providing and receiving social support on mortality was examined using Cox regression analysis after adjusting several covariates.
The effect of the dietary n-3 long-chain PUFA , DHA ( @number@ : 6n-3 ) , on the growth of pre-term infants is controversial.
The effect of the metabolic syndrome ( MetS ) on this yearly change has never been explored.
The effect of the most significant single-nucleotide polymorphism at all genome-wide significant loci on serum urate was added to create a genetic urate score.
The effect of the oxidative chlorine content and morphology / size on the antimicrobial capability was constructed as well.
The effect of these changes on the health of the individual and implications for practice are described in Part @number@
The effect of these risk factors may be especially pronounced in some racial and ethnic populations.
The effect of these treatments on PS exposure was measured by flow cytometric analysis of annexin V binding.
The effect of the various predictors on IHC ordering rates was similar in both groups.
The effect of the viscosity of a liquid on the amplitude of a pressure wave was then considered using a phantom simulating human blood vessels.
The effect of thinning plates and rods on the transverse relaxation can be understood in terms of simple cylinders and open walls.
The effect of this ALDH2 polymorphism on the lung and its stem cells has not been thoroughly examined.
The effect of this highly branched microstructure on the local mechanical properties is investigated by means of numerical simulations.
The effect of this mutation results in a strong reduction of PYCR1 expression in skin fibroblasts from affected siblings.
The effect of this polymorphism on cognitive function in middle-aged healthy women is not well known.
The effect of traffic on parasympathetic tone was stronger among diabetic as compared to non-diabetic participants.
The effect of unilateral oophorectomy acutely or in the long-term on ORT is not known.
The effect of vascular pathology on cognitive decline was not significantly different according to AD pathology.
The effect of Wnt signaling on the activation of satellite cells , rather than Wnt-mediated fibrosis , was observed in both adult and aged mice.
The effect on all-cause and cause-specific mortality rate was also assessed after a mean follow-up of @number@ years.
The effect on bone microarchitecture and fracture risk has never been studied.
The effect on health outcomes , such as morbidity and mortality , remains to be assessed.
The effect on personal growth and purpose in life was particularly strong.
The effect remained after adjusting for sociodemographic status , life habits and metabolic indicators.
The effects are particularly important in existing ischemic brain injury.
The effect seems to differ depending on educational level.
The effects induced by mechanical changes on body kinematics were very small.
The effect size estimate of the different Framingham methods varied noticeably ; reasons for those differences warrant further investigation.
The effect size in males was @percent@.
The effect size was @number@ μmol / l ( p < @number@ ) when pooling the @number@ studies where serum creatinine levels were reported.
The effect size was roughly similar at both ages ( Cohen's d≈0.32 ) .
The effects of accelerated ageing after gamma irradiation on morphological , mechanical and thermal properties of HDPE / HA nano-composites were measured.
The effects of ACE alleles / genotypes on incident dementia risk were small.
The effects of age-20 interaction quality on midlife outcomes , on the other hand , were mediated by age-30 interaction quality.
The effects of age and gender on the regional distribution of those properties were examined.
The effects of age and hearing loss on recognition of unaccented and accented words of varying syllable length were investigated.
The effects of age and hypertension on vessel diameter were also examined.
The effects of age and race were estimated using Generalized Estimating Equations , while accounting for intradonor correlations.
The effects of age , gender , and repeated measures ( three trials in a single session ) on MPT were assessed.
The effects of age on the relationship between anxiety and haemostasis should be further investigated.
The effects of aging , gender , and their interaction are presented in the specific biomeasure papers included in this Special Issue.
The effects of aging on central hemodynamics during exercise have not been well characterized.
The effects of aging on PE-induced responses were also investigated.
The effects of aging on suprahyoid muscle strength are unclear.
The effects of aging were determined by testing for linear trends using regression analysis.
The effects of anti-photoaging and anti-inflammation were analyzed by Enzyme-linked immunosorbent assay ( ELISA ) , immunoblotting and immunochemistry.
The effects of apolipoprotein E ( Apo E ) polymorphism on MetS are not well established.
The effects of a variety of comorbidities on IQS and / or on the relationship between IQS and aASM were assessed using multiple regression models.
The effects of bilingualism should be considered when cognitively screening is performed in aging immigrant populations.
The effects of both topical and oral administration of VAE were tested in UVB-irradiated hairless mice.
The effects of caloric restriction on DNA methylation were detectable across different tissues and correlated with gene expression.
The effects of carbocysteine on TLR4 expression and on the TLR4 activation downstream events are largely unknown.
The effects of cardiac resynchronization therapy ( CRT ) on libido and erectile function have not been previously evaluated.
The effects of childhood conditions were , in part , both mediated and modified by social class in adulthood.
The effects of chronic disease and sustained use of alcohol , tobacco , and medications often exacerbate age-related GI dysfunction.
The effects of cognition on mortality did not differ by sex.
The effects of cognitive reserve on 18F-FDG uptake were investigated using years of education as a proxy.
The effects of cortisol on the telomere system are complex and may depend on the intensity and duration of exposure.
The effects of density gradient centrifugation and aging of males on CREM promoter methylation were also investigated.
The effects of dietary krill oil on neurocognitive functions and proteomic changes in brain tissues of d-galactose-induced aging mice were evaluated.
The effects of different intervention programs on physical fitness were also described.
The effects of different preprocessing steps on these results were then explored.
The effects of education and sex on baseline performance versus change suggest a role for life experiences in cognition.
The effects of fatigue on postural control are more important when proprioceptive information at the ankle is altered.
The effects of high-intensity progressive resistance training ( HIPRT ) on cardiovascular function and autonomic neural regulation in older adults are unclear.
The effects of household income were also similarly mediated by the identical variables.
The effects of hyperthyroidism on B-cell physiology are still poorly known.
The effects of IL-21 are pleiotropic , owing to the broad cellular distribution of the IL-21 receptor.
The effects of insomnia symptoms on fall risk differed by sleep medications use.
The effects of integration were examined when discriminating 1-3 flashes , 1-3 beeps , or 1-3 flashes presented with 1-3 beeps.
The effects of intensive LDL-C lowering on neurocognition might be attributed to an off-target effect.
The effects of L5 were attenuated in mice deficient for L5's receptor , lectin-like oxidized LDL receptor @number@ ( LOX-1 ) .
The effects of long-term supplementation with SSE on arterial stiffness in human subjects were evaluated.
The effects of mammalian MsrBs , including selenoprotein MsrB1 on fruit fly aging , have been investigated.
The effects of medications will be discussed and linked to oral complaints patients may express.
The effects of milk protein supplementation and low intensity home based physical exercise on body composition and muscle functions were investigated.
The effects of miR-144 were evaluated by cell proliferation , migration , transwell , and tumorigenicity assays.
The effects of mitochondrial retrograde signaling may even spread to other cells / tissues in a noncell autonomous manner by yet unidentified signaling mediators.
The effects of mTBI on Aβ accumulation remain uncertain because of a lack of mTBI pathology data.
The effects of mTOR pathway on degradation of phagocytosed photoreceptor outer segments ( POS ) were determined by measuring the turnover rate of rhodopsin.
The effects of NE on memory CD8 T cells were primarily mediated by ADRB2 as confirmed by the adrenergic receptor agonist and antagonist assays.
The effects of normal aging and orthopedic conditions on gait patterns during customary walking have been extensively investigated.
The effects of obesity on the respiratory system have received less attention and are the subject of this article.
The effects of oxidative stress on chondrocytes are still unknown.
The effects of oxidative stress on MSCs are still unknown.
The effects of oxidative stress on PTHR signaling and trafficking have not been elucidated.
The effects of physical activity on brain function can be assessed through event-related potentials ( P300 ) that reflect cortical activities related to cognitive functions.
The effects of physical exercise on mental health have been extensively investigated , mainly in older people.
The effects of postmenopausal estrogen replacement on thyroxine requirements in women with hypothyroidism should be considered.
The effects of price run-ups were concentrated on homeowners , as opposed to renters , suggestive of wealth-driven effects.
The effects of PTD-EGF and FGF1 were examined by WST assay , Western blotting , immunohistochemistry , and skin wrinkle parameters.
The effects of PT were similar but weaker.
The effects of quality of close social relationships in later life on the risk of developing dementia are not well understood.
The effects of rs3734355 / 4 on SIM1 activity were tested using an in vitro reporter assay.
The effects of schisandrin B ( Sch B ) and its analogs on solar irradiation-induced oxidative injury were examined in BJ human fibroblasts.
The effects of scopoletin on autophagy and anti-aging were investigated in human lung fibroblast cell line , IMR @number@
The effects of serum FSH on BDR were approximately @date@ @number@ folds than those of serum E2.
The effects of sex , age and their interactions on muscle properties were analyzed.
The effects of some specific foods in the context of overall diet warrant further study.
The effects of sub-lethal oxidative stress regarding proliferation and telomere biology were more distinct in senescent cells.
The effects of swimming exercise and caffeine on oxidative stress in muscle and liver of middle-aged rats were also investigated.
The effects of the ageing process on thermoregulatory responses are discussed and the presenting symptoms of heat exhaustion and heatstroke are outlined.
The effects of the chain length , loading and grafting ratio of the QAS were significant.
The effects of the different tasks are consistent in the two age groups.
The effects of the HCSMP-NHR were measured three times : at baseline , week @number@ and week @number@
The effects of the intervention were analyzed with generalized estimating equations.
The effects of the programs on the attention and memory functions were assessed by means of the symbol digit modality test.
The effects of these processes on the function of distributed cognitive networks , however , are poorly understood.
The effects of these risk factors from childhood on midlife cognitive performance are unknown.
The effects of this genotype on PWV were not related to the presence of antihypertensive treatment.
The effects of training were generally maintained in both practiced and unpracticed memory tasks.
The effects of TRT on these abnormalities are not entirely clear.
The effects of water-storage were material-dependent , and significantly affected the mechanical properties and silver uptake patterns of adhesives.
The effects of widowhood on subjective health differed significantly at both time points.
The effects of WML on connected GM regions were assessed using the Change in Connectivity ( ChaCo ) score.
The effects on dauer formation and lifespan require the aak-2 / AMPK gene , and tatn-1 mutations increase phospho-AAK-2 levels.
The effects on glucose metabolism and serum IL-6 levels were evaluated after @number@ weeks of hybrid training.
The effects on medical care utilization were varying.
The effects on mortality rates were examined using age-period-cohort ( APC ) models.
The effects on prostate and urinary function and hematocrit were within safe margins.
The effects on the V̇O2peak and lifestyle-related disease score were evaluated every @number@ mo.
The effects persisted in the majority ( ∼80% ) of subjects without repeat treatment for at least one interval of @number@ weeks.
The effects remained mostly unchanged after controlling for medication.
The effects seem to be associated with a decline in updating and maintaining representations during perceptual encoding.
The effects were more pronounced in ADL and IADL disability scales in which QoL moderated both linear and quadratic age-related changes.
The effect was attenuated among women living in areas with lower educational attainment and was negligible among Hispanic women.
The effect was greatest in the mid-thoracic area.
The effect was more pronounced in the peripheral area , and the effect increased with age.
The effect was statistically significant in the subpopulation of the elderly who harbored C. difficile at the start of the study.
The efficacy and safety of prolonged DAPT has been questioned.
The efficacy did not improve at higher injection doses , with the four-unit regimen generally not being more potent than the two-unit regimen.
The efficacy of an autograft can be traced back to multipotent stem cells residing within the bone graft.
The efficacy of immunotherapy in cancer patients is influenced by differences in their immune status.
The efficacy of long-term nutritional supplementation in combination with physical activity in older adults remains unclear.
The efficacy of MI as an adjunct in the treatment of pediatric obesity remains relatively understudied.
The efficacy of PR was defined as a 54-m increase in 6-min walk distance or a four-point decrease in St. George's Respiratory Questionnaire score.
The efficacy of spermine was investigated on induction of autophagy through histone deacetylation and p53 activation in human fibrosarcoma cell line , HT1080.
The efficacy of statin therapy was not associated with Taq1B polymorphism.
The efficacy of sunscreens can be measured by different methods , involving in vitro , ex vivo , or in vivo techniques.
The efficacy of sunscreens to protect against ultraviolet ( UV ) A radiation is usually assessed by measuring erythema formation and pigmentation.
The efficacy of the antioxidant systems , e.g. , glutathione and thioredoxin , is an important factor in pathophysiology of the aging nervous system.
The efficacy of these interventions is debated , mainly due to methodological differences between studies.
The efficacy of these strategies for preventing subsequent adverse outcomes has been limited to small studies to date.
The efficacy of the treatment is evaluated at visits @number@ to @number@ by documenting all existing and new AK lesions in the face.
The efficacy of this agent has previously been demonstrated in an in vivo study using an electrophysiological protocol in a rat model.
The efficacy of triple standard therapy is clearly inadequate.
The efficacy of using an objective assessment method to measure the extent of use of wheelchairs was demonstrated in this study.
The efficacy outcome was International Prostate Symptom Score ( IPSS ) .
The efficacy was evaluated with Pearson chi-square or Fisher's exact tests , Log-rank test and Cox proportional hazards model.
The efficacy was presented as comparing ever versus never vaccinated people during the entire study period without regard to seasons.
The efficiency of polymerisation is considered an essential property for all polymers.
The efficiency of somatic energy metabolism is correlated with cognitive change over the lifespan.
The efficiency of the cellular defenses decreases in stressed or aging neurons , leading to neuroinflammation , apoptosis and tissue loss.
The EFP will be argued to be a place theory which subsumes themes of emergent environmental gerontology theories within a developmental science perspective.
The eGFR was calculated using equations from the CKD Epidemiology Collaboration and Modification of Diet in Renal Disease studies.
The egocentric component looked less affected by aging.
The E group exhibited a significantly increased handgrip strength at postintervention.
The EG underwent @number@ months of VR memory training ( VRMT ) that involved auditory stimulation and VR experiences in path finding.
The eigenstrat method showed no stratification.
The eigenvectors that define the variations in the spectra provide clues to the compositional changes that occur in meibum with age.
The eight individual IADL items clustered clearly around physical , mental or combined mental and physical IADLs.
The elaboration of specific epigenetic marks is also linked with regulating sex hormone signaling pathways later in life.
The elderly adults also showed enhancement after the 12-hr period , revealing brain plasticity similar to young adults.
The elderly age group ( ≥65years of age ) is one of the fastest growing populations.
The elderly and chronically ill patients are affected mostly.
The elderly are among those who benefit most from preventive measures against acute renal failure.
The elderly are generally with poor health and low information literacy.
The elderly are highly susceptible to sepsis-induced organ injury.
The elderly are often treated with several medications , which may have both beneficial and deleterious effects.
The elderly are particularly susceptible to trauma , and their outcomes are frequently dismal.
The elderly are prone to postprandial hyperglycemia that increases their cardiovascular risk.
The elderly are prone to suffer more diseases than the young.
The elderly are susceptible to many disorders that alter the gait pattern and could lead to falls and reduction of mobility.
The elderly didn't show this kind of pattern.
The elderly facing health and economic challenges are at higher risk of not receiving filial support than other elderly individuals.
The elderly go through life facing social , economic and financial hardships.
The elderly group also showed larger inter-fingertip distances with arch-like fingertip trajectories compared to the young adult group for all object sizes.
The elderly group presented decreased ALA-D activity compared to the young group.
The elderly group was characterized by a higher incidence of comorbidities and a lower incidence of eating behavior disorders at baseline.
The elderly had more flexed knees at the instant of ground contact.
The elderly has been under-represented in clinical trials of cancer therapy , even in the era of targeted therapy.
The elderly have difficulty mounting protective immune responses against newly encountered antigens.
The elderly have increased chronic diseases and complications with aging , and the adverse event in medication therapy also increases.
The elderly have unique alterations in physiology that put them at a greater risk of toxicity from chemotherapy and biologic therapy.
The elderly in Belo Horizonte in @number@ represent @percent@ of total population residing therein.
The elderly in North America represent the fastest growing segment of the population and the most common skin complaint in this age group is pruritus.
The elderly in palliative care are confronted with difficult decisions relating to treatments.
The elderly may develop all types of the disease but are most prone to drug-related acute renal failure.
The elderly modulate their performance in response to positive and negative feedback differently from young adults , showing a classical positivity effect.
The Elderly Nutrition Program ( ENP ) is being challenged to improve the quality of meal programs.
The elderly often complain of numerous comorbidities that complicate the determination of the cause of pruritus , as well as its treatment.
The elderly participants predominately showed 1-4 years of education , with non-participants @number@ - @number@
The elderly participants produced lower force magnitudes by noninstructed fingers and higher force magnitudes by instructed fingers in nontask directions.
The elderly patient-healthcare provider relationship has unique legal and ethical aspects that require deep reflection and special training.
The elderly patients had a patient clinical complexity level of mean @number@
The elderly patients revisited our hospital with another trauma more frequently than did the younger patients ( P < @number@ ) .
The elderly person who chooses to have dialysis will frequently have different requirements than younger patients.
The elderly population has less pulmonary reserve , and cough strength is decreased in the elderly population due to anatomic changes and muscle atrophy.
The elderly population is heterogeneous.
The elderly population is increasing progressively.
The elderly population is increasing worldwide.
The elderly population is particularly vulnerable to the acute challenges of muscle disuse atrophy.
The elderly population is rapidly growing and particularly diverse.
The elderly population is rapidly increasing in number.
The elderly population is very heterogeneous.
The elderly represent a large percentage of patients seen in departments of vascular surgery.
The elderly represent the largest-growing segment of the population.
The elderly residents of public nursing home belonged to the group distinguishing negatively compared to other two study groups.
The elderly sample took substantially longer to complete the activity ( almost @percent@ ) with longer trajectories compared with the young sample.
The elderly should consume foods and fruits with laxative and stool-softening properties to prevent constipation.
The elderly show deficiencies in immune function.
The elderly tended to die from liver-unrelated causes.
The elderly were capable of recognizing an upcoming predictable perturbation and activated muscles prior to it.
The elderly were divided into PiB ( + ) and PiB ( - ) groups based on radiotracer retention.
The elderly were separated in two groups ( active and moderately active ) according to HAP.
The elderly who had never worked in a lifetime were @number@ times more likely to report poor health.
The elderly with one or more than one chronic condition had the odds of @number@ times and @number@ times respectively , of reporting poor health.
The elder patients had a faster increment in incidence.
The electrocardiogram , and finger and ear photoplethysmograms were recorded simultaneously.
The electrocardiographic diagnosis of hyperkalemia and acute myocardial infarction in paced rhythms is also discussed.
The electrocardiographic QRS duration , a measure of ventricular depolarization and conduction , is associated with cardiovascular mortality.
The electrochemical methodology presented here could open up new possibilities in research on protein glycation and oxidative modification.
The electroencephalogram ( EEG ) of wakefulness , sleep , and anaesthesia changes during childhood.
The electroencephalograms from @number@ patients with localization-related epilepsy were analyzed to compare the distribution of spike foci in different age groups.
The electroencephalogram signal reflects the electrical activity of the neurons in the cerebral cortex.
The electromagnetic approach has intriguing advantages over the conventional and frequently implemented ray optics analysis.
The electronic database at the Chinese People's Liberation Army General Hospital includes discharge records for all patients treated in the hospital.
The electronic system developed at Toronto Rehabilitation Institute automatically detects hand hygiene opportunities and records hand hygiene actions.
The elements that comprise the components of successful aging , especially physical health , may be better targets for intervention.
The elevated CerS6 activity resulted in accumulation of the pro-apoptotic C16 : @number@ ceramide , which facilitates the mitochondrial apoptosis in response to oxidative stress.
The elevated complexity of pV̇O2 dynamics is a consequence of a multiple-order interaction between muscle oxygen uptake and circulatory distortion.
The elevated iron was not associated with the amyloid plaques.
The elevated level of α2M mRNA has been described in replicative senescence and it could be used as a biomarker of the aging cells.
The elevated nigral iron levels observed in PD may reflect a dysfunction of brain iron homeostasis.
The elevated OCN at these stages represents enhanced bone turnover and metabolic activity , which require more energy supply.
The elevated SIRT1 was accompanied by enhanced activation of the Akt / p70S6K1 signaling pathway in response to GR.
The elevation of intracellular Ca ( 2 + ) induces degranulation and oxidative stress.
The elevation of the hyoid bone is important for swallowing and is controlled by the suprahyoid muscles.
The ELF-EMF accelerates wound healing modulating expression of the MMP-9 via Akt / ERK pathway.
The elimination of expanded T cells at the end of immune response is crucial to maintain homeostasis and avoid any uncontrolled inflammation.
The elimination of oxidatively modified proteins is a crucial process in maintaining cellular homeostasis , especially during stress.
The elimination of senescent cells from aged mice not only attenuates progression of already established age-related disorders , but also extends median lifespan.
The elimination was not associated with more hospital or skilled nursing facility admissions or with longer lengths-of-stay in a skilled nursing facility.
The ELISA assay of the sera also supported an increasing SHBG level along with age.
The ELISA displays a wide working range ( @number@.6-538.4µg / L ) , high accuracy ( @percent@ ) and good precision ( @percent@ ) .
The elliptical shape of the LC was also predictive of the biaxial strain ratio.
The elongated polyglutamine ( polyQ ) stretch in the N-terminal region of htt leads to dysfunctional and degenerative events in neurons and peripheral tissues.
The eluates were analyzed by gas chromatography / mass spectrometry.
The elution time of endogenous placental MBG-like immunoreactive material from reverse-phase HPLC column was identical to that of authentic MBG.
The Emax for oxazepam and nordiazepam were sleepiness or obtundation in @number@ and @number@ cases , respectively.
The emergence of active control mechanisms allows infants to integrate sensory information into their movements so that they can exhibit more adaptive sitting.
The emergence of a useful mouse model should facilitate the development of novel therapeutic approaches.
The emergence of drug-resistant fungi poses a major threat to human health.
The emergence of interprofessional education and competencies is a development that is relevant to social work practice in this field.
The emergence of persister cells during chronic infections is critical for persistence of infection , but little is known how this occurs.
The emergent realist perspective on evaluation is instructive in the quest to use theory-informed evaluations to reduce health inequities.
The emergent themes and perceptions were then added to the BEMI-C through synthesis of findings.
The emergent themes were used to inform the design of the educational program delivered to adolescents and evaluated in Study @number@
The emerging concept of organ engineering may offer a new hope for these patients.
The emerging therapies tasquinimod and ipilimumab are reviewed.
The EMG activity of first dorsal interosseus ( FDI ) and second palmar interosseus ( SPI ) muscles was measured with intramuscular electrodes.
The E.M.I. score and the associated pattern of corneodesmosome breakdown may be used as markers of the stratum corneum maturation.
The emotional processing of musical excerpts following stroke has been relatively unexplored.
The emotional stress of bereavement is associated with suppressed neutrophil superoxide production and with a raised cortisol : DHEAS ratio.
The emphasis in disaster situations is on preserving life , and this goal is both appropriate and laudable.
The emphasis is on key age-related characteristics that influence the interpretation of tissue changes by the toxicologic pathologist.
The emphasis is on possible molecular mechanisms controlling PIMT expression and the ability of PIMT to repair isomerized substrates during aging.
The emphasis is on preferences for care and not actual care received.
The empirical analysis supports this proposition , with both arrest and self-reported crime blocking the passage to adult status.
The empirical material consists of @number@ articles from the Swedish news-press from the years 2013-2014.
The empirical P value for the combined result was @number@
The empirical regression curves often crossed each other.
The employment- and health-related consequences could be identified up to @number@ years before the first diagnosis and increased with disease advancement.
The employment rate increased from @percent@ before surgery to @percent@ at final follow-up ( P < @number@ ) .
The EM was an adipo-fibro-vascular tissue with various histomorphologies , blending with the periradicular sheath.
The encoding conditions were as follows : word / word , picture / picture , picture / word , and word / picture.
The encoding regions of SQSTM1 were screened by direct sequencing.
The encounter with multimorbid patients has become the most common situation in the health care system.
The endocrine system plays a major role in orchestrating cellular interactions , metabolism , growth , and senescence.
The endocrinology of the aging male is complex , with multiple hormones along the ( HPT ) axis interacting with one another in feedback.
The end of the year can trigger the recognition that aging adults are no longer as independent as they once were.
The endogeneity-corrected models produced implausibly large main effects of supplemental insurance , but the Cancer × Insurance interactions were similar in both models.
The endometriosis diagnosis was confirmed by videolaparoscopy and the controlled ovarian stimulation protocol was similar to all patients.
The endometrium is apparently involved in the mechanism underlying IVF failure in smokers.
The endoplasmic reticulum ( ER ) is a cellular compartment that has a key function in protein translation and folding.
The endoplasmic reticulum ( ER ) is a multifunctional organelle critical for the proper folding and assembly of secreted and transmembrane proteins.
The endoplasmic reticulum ( ER ) is the major lipid-synthesizing organelle.
The endosomal-lysosomal system plays important roles in cellular physiology.
The endosome is increasingly recognized as an important crossroad for APP and these secretases , with major implications for APP processing and amyloidogenesis.
The endothelial cell loss showed a statistically significant negative correlation with the initial subbasal nerve density ( Rs = @number@ P = @number@ ) .
The endothelial NO component of prostacyclin ( PGI ( @number@ ) ) -mediated vasodilation is reduced in aging.
The endothelin receptor type A ( ETA ) antagonist BQ123 increased extracellular levels of ET-1 in human fetal astroglial cell line ( SV-FHAS ) .
The endothelium-dependent vasodilation was assessed by acetylcholine iontophoresis and the endothelium-independent vasodilation by sodium nitroprusside iontophoresis.
The endothelium is a key constituent of the vascular wall , being actively involved in maintaining the structural integrity and proper functioning of blood vessels.
The endothelium is a key player in vascular control and appears to be also disrupted in many compensatory functions ( i.e. , vasodilation ) .
The endothelium is located in a strategic anatomical position within the blood vessel wall and thus constitutes a barrier between the blood and all tissues.
The endothelium of liver sinusoids in relation to the endothelium of other blood vessels has specific antigen expression similar to the endothelium of lymphatic vessels.
The endothelium of sinusoids and lymphatic vessels express LYVE-1 , and the endothelium of lymphatic vessels express LYVE-1 and D2-40 but not CD34.
The endothelium plays a critical role in the maintenance of cardiovascular health by producing nitric oxide and other vasoactive materials.
The Endotine was always palpable under the skin but visible in only roughly half of patients.
The endpoint of interest was late recurrence of AF.
The endpoints were the HCV sustained virological response ( SVR ) and the HBV virological / clinical reactivation.
The endpoints were total brain volume and anatomical regions.
The end point was all-cause death during a mean follow-up of @number@ days.
The end point was all-cause mortality during a mean follow-up period of @number@ days.
The end point was death from stroke.
The endpoint was overall mortality.
The end result is a fatty , ptotic perioral mound of tissue that is not well addressed by conventional rhytidectomy.
The end result is an accelerated loss of articular cartilage and increased erosion of the joint.
The end result is a well-defined , well-contoured neck , with an approach grounded in sound anatomical principles.
The end result is improved self-management , increased quality of life , reduced hospital admissions , and an associated decrease in societal costs of HF.
The energy expenditure from chronic inflammation contributes to weight loss.
The energy function is efficiently minimized by a graph cut method.
The energy levels ranged from 30-70 mJ with coverage between @percent@ and @percent@.
The engagement of amygdala functional network also contributed to higher memory performance and faster response times in older adults.
The engineering principle of safety factors ( maximal capacity divided by routine functioning ) may also be informative.
The English MoCA was translated into Cantonese Chinese and then back-translated.
The enhanced fatty acid oxidation observed in SIRT4 KO hepatocytes requires functional SIRT1 , demonstrating a clear cross talk between mitochondrial and nuclear sirtuins.
The enhanced parietal connectivity was associated with the clinical and cognitive deficits of the patients.
The enhanced post-movement rebound in young subjects potentially reflects post-training plastic changes in SM1.
The enhanced potency of GO-Y030 may make it more useful than curcumin , which suffers from low bioavailability.
The enhanced response of aged naïve CD4 T cells is dependent on IL-6 produced by the DC.
The enhancement of each of these parameters by platelets was abrogated by the present of metformin in the vast majority of cancer cell cultures tested.
The enhancement of the T-cell-mediated natural immune defense might be one of the important underlying mechanisms for probiotics to express their anti-infective effects.
The eNOS protein level was significantly decreased in older people as compared to adults.
The enriched environment ( EE ) began in the adulthood ( @number@ months ) and lasted for @number@ months.
The ENS can be affected by environmental factors , diet and disease.
The enteric nervous system ( ENS ) orchestrates a broad range of important gastrointestinal functions such as intestinal motility and gastric secretion.
The enthesopathies were recorded as either present or absent.
The entire genomic sequence of HBV recovered from this patient revealed no mutations in the core promoter and precore regions that interfere with HBeAg production.
The entire Japanese public was profoundly affected by \ " @date@ . \ "
The entire population and subgroups stratified to age and spherical equivalent were analyzed.
The entropy of males at birth was lower than that of females.
The environmental and growth conditions and especially the substrate determine whether toxin formation occurs , but indoor air concentrations are always very low.
The environmental components for AUD correlated over time ( r = @number@ ) , but not for MDD.
The environmental , social or physical unmet needs , respectively , showed less or no meaningful predictive value for variance in depression severity.
The environment of the carbonyl band becomes less polar with increasing age.
The enzyme 5-lipoxygenase ( 5-LOX ) has been revealed responsible for producing fatty acid molecules , leukotrienes.
The enzyme acetyl-CoA carboxylase @number@ plays an important role in biotin accumulation within adipose tissues of Adipo-H363Y.
The enzymes involved in catecholaminergic and cholinergic metabolism were determined by both immunohistological and western blot analyses.
The enzymes of purine metabolism have been documented to be particularly sensitive to the effect of dietary L-arginine supplementation.
The enzymes serine hydroxymethyltransferase @number@ ( gene name SHMT1 ) and methylenetetrahydrofolate reductase ( gene name MTHFR ) regulate key reactions in folate-mediated one-carbon metabolism.
The enzyme telomerase is active in germ cells and is critically involved in maintenance of telomere length in successive generations.
The EOVs performed at the other NHs consisted of one session of three hours of lectures about the guidelines.
The ephemeral effects of neurotoxins and fillers are well described for facial remodeling and rejuvenation.
The epidemiological data , in addition to disability weights , were used to calculate years of life lived with disability ( YLDs ) .
The epidemiological shift and aging population make cancers a challenge.
The epidemiological transition has produced a society with a growing number of the elderly affected by multiple chronic diseases which often requires polypharmacy.
The epidemiology of AD in advanced age is highly relevant but deceptively challenging to address given the low autopsy rates in most countries.
The epidemiology of iatrogenic disease in the elderly has not been extensively reported.
The epidemiology of invasively-treated PAD in Taiwan was estimated , and the influences of potential confounders on these invasively-treated methods were evaluated.
The epidemiology of kidney disease in HIV-infected individuals has changed significantly since the introduction of combination antiretroviral therapy ( cART ) in the mid 1990s.
The epidemiology of methicillin-resistant Staphylococcus aureus ( MRSA ) in the community in Portugal is not completely understood.
The epidemiology of valvular heart disease has significantly changed in the past few decades with aging as one of the main contributing factors.
The epidermis of non-smokers showed positive hTERT in @percent@ and negative hTERT in @percent@ of biopsies ( P > @number@ ) .
The epidermis of smokers showed positive hTERT in @percent@ and negative hTERT in @percent@ of biopsies.
The epidermis of the skin is a highly polarized , metabolic tissue with important innate immune functions.
The epidermis was explored using the CD44 variant @number@ and Ki67 immunolabellings.
The epigenetic modulation of CD20 coding gene ( BACKGROUND : Living independently can be challenging for seniors.
The epigenetic switch is not fixed.
The epigenome , consisting of chromatin and its modifications , acts as a link between the inherited genome and the changes imposed by the environment.
The epigenome is of fundamental importance for development and ageing.
The epileptic syndromes , notably the temporal lobe epilepsy , frequently include memory disturbances.
The epithelial-mesenchymal transition is involved in several physiological processes.
The Epstein Barr virus oncogene LMP1 , the anti-apoptotic Bcl-2 protein and the tumor suppressor p53 have recently emerged as biomarkers of the disease.
The EQ-5D index of the elderly was found to be @number@ ( @percent@ confidence interval = @number@.862-0.880 ) .
The equation obtained was used to correct our own previous RI ( DSL RIA ) for infancy for the Diasource RIA.
The equation ( right-left ) / ( right + left ) was used to calculate frontal asymmetry as a marker of approach-related emotions.
The equations were then contrasted to a number of equations reported in the literature.
The ergothioneine content of GEB was @number@ mg / mL DW.
The erosion of telomeres is an important mechanism for regulating the aging process by limiting cell proliferation.
The ERP analyses suggest that these impairments reflect deficits in the ability to build up relational representations of ambiguous outcomes.
The ERP data revealed larger P3b amplitudes for context-dependent than for context-independent trials only in younger adults.
The ERP results revealed a dynamic temporal-spatial change in older adults.
The error rate is highest for the ELT and lowest for the SAT.
The error rate is highest for the SAT and lowest for the ELT.
The error rate was @percent@ ( @percent@ when omitting timing errors ) .
The erythema index and melanin index on the PRP-treated side were lower than on the control side.
The erythrocyte activities of GSH-Px , SOD and CAT were significantly decreased during perimenopausal and postmenopausal phases compared to reproductive phase.
The erythrocyte deformability and heme degradation for @number@ subjects with SCD and @number@ with sickle trait were compared with normal healthy adults.
The erythrocyte lysis was observed in hypotonic solution of buffered saline at varying concentrations and optical density was measured at @number@ nm.
The ES CSC model , histopathogenesis , histogenesis , pathogenesis , ES mediated Hematopoietic stem progenitor cells ( HSPCs ) senescence are also discussed.
The essentiality of tau to mediate cognitive decline by environmental perturbations needs further investigation.
The essential role of peroxisomes in fatty acid oxidation , anaplerotic metabolism , and hydrogen peroxide turnover is well established.
The essential trace metals iron , zinc , and copper play important roles both in retinal physiology and disease.
The established model was then valided independently on the second database.
The established standard of care is modified radical mastectomy followed by tamoxifen for endocrine-responsive positive disease , although other options are being explored.
The establishment of an efficient exchange of information between the cerebral hemispheres is of crucial importance in the developing functionally lateralized brain.
The establishment of centres of excellence with a high patient volume has lowered the complication and increased the resection rate.
The establishment of different normal cutoffs seems to be complicated and uroflowmetry data should be interpreted with caution in order to avoid misdiagnosis.
The esthetic results were satisfactory in @number@ patients ( @percent@ ) .
The estimated annual number of adult COP cases in the entire Japanese population was @number@ and @percent@ were aged ≥ @number@ years.
The estimated areas under the receiver operating characteristics ( ROC ) curves suggested a clinically negligible difference between the two indices.
The estimated average requirement ( EAR ) method was adopted as a cut-off point for estimating the prevalence of inadequate intake.
The estimated brain pathological age could be not only more helpful for the classification of AD but also more precisely reflect the accelerated brain aging.
The estimated cost saving effect of improving vitamin D status in Germany might be up to @number@ billion euros annually.
The estimated CVD risk can be used to quantify risk and to guide preventive care.
The estimated glomerular filtration rate decreased with age over @number@ years in a similar way to the general population.
The estimated ICER was $ @time@ ( @percent@ confidence interval $ @time@ - $ 39.37 ) per additionally vaccinated Medicare elderly in a probabilistic analysis.
The estimated impedance modulus and phase are similar to those observed in the systemic circulation and other vascular beds.
The estimated increase in purchase probability from experience with LTC is about half the previously estimated increase from tax policy-induced price decreases.
The estimated median score for an individual age @number@ years was @number@ increasing with age to @number@ for an individual age @number@ years.
The estimated number of MG patients in Japan was @number@ giving a prevalence of @number@ per @number@
The estimated parameters were then applied to California-specific data.
The estimated presymptomatic phase of the disease spanned more than @number@ decades in younger patients , compared to @number@ decade in older patients.
The estimated prevalence of physical frailty with cognitive impairment was @percent@ , and physical pre-frailty with cognitive impairment was @percent@.
The estimated prevalence of SD was @percent@.
The estimated prevalence rate of HF was @number@ persons per @number@ adults.
The estimated shear force was calculated by substituting these values in the model.
The estimated strength increases were greater in trabecular than peripheral bone and greater in the spine than hip.
The estimated total costs were €465 million.
The estimated value of dietary protein intake was @number@ g / kg / day.
The estimates for the other cancer sites were considerably lower , ranging from @number@ ( colon-rectum ) to @number@ ( cervix ) .
The estimates include smoking-attributable health care expenditures and productivity losses from smoking-caused mortality.
The estimates suggested that there could be large cost offsets to Medicare and Medicaid from the slowing of AD progression among patients with mild AD.
The estimates were robust in confounder-adjusted models , but attentuated when excluding subjects with baseline prevalent or follow-up incident diabetes.
The estimate was attenuated after full adjustment ( OR = @number@ [ @percent@ CI : @number@ @number@ ] ) .
The estimation of FMR can be readily carried out using existing software implemented for functional principal component analysis and mixture regression.
The estrogen agonist-antagonist tamoxifen did not affect telomere biology , but inhibited the E ( @number@ ) -stimulated reduction in telomere shortening.
The estrogenic effect of EE2 in O. latipes was confirmed by significant up-regulation of four key estrogen responsive genes in the liver.
The estrogen receptors , ERα and ERβ , function as hormone-dependent transcription factors that directly regulate the expression of their target genes.
The etched surfaces were silanized and resin cement was applied.
The ethanol extract of Tilia taquetii Schneider leaves was investigated for its anti-wrinkle properties and for the relevant chemical constituents.
The ethical dimension of treating the elderly , including risk-benefit analysis , focuses mainly on quality of life and end-of-life issues.
The ethical , logistical , and biological complications of working with an older population of people inherently limits clinical studies of frailty.
The ethical problems that arise in the care of dying patients are numerous and complicated.
The ethnic composition was @number@ Malays and @number@ Chinese children ( Willems dental age = @date@ @number@ years ) .
The ethnic difference was attributed to significantly higher GST levels among Mexican-Americans.
The ethnomedical uses of Polygonum multiflorum have been recorded in many provinces of China and Japan for nine species of adulterants in six families.
The ethyl acetate extract of S. brachypetala bark and leaves of P. capensis inhibited elastase activity by more than @percent@.
The ET / ICA / midline angle varied from @number@.0- to @number@.6- ( average @number@.7- ) .
The etiological mechanisms underlying the neuropathological changes in AD remain unclear , but are probably affected by both environmental and genetic factors.
The etiological mechanisms underlying these neuropathological changes remain unclear , but are probably caused by both environmental and genetic factors.
The etiologies of disabilities are many , including genetic , congenital , traumatic , or due to chronic illnesses or the aging process.
The etiology and pathogenesis of floaters ' formation is still not well understood.
The etiology of Alzheimer's disease ( AD ) is complex with oxidative stress being a possible contributory factor to pathogenesis and disease progression.
The etiology of anemia in CF-LVAD was primarily due to accelerated erythrocyte aging.
The etiology of functional limitations in elderly people is complex and often ascribed to conditions that escape the traditional definition of disease.
The etiology of GBM is unknown.
The etiology of PD is unknown , although aging and neurotoxins are established risk factors.
The etiology of PD remains unclear.
The etiology of radiation-induced cardiovascular disease ( CVD ) after chronic exposure to low doses of ionizing radiation is only marginally understood.
The etiology of sarcopenia in the elderly is multi-factorial.
The etiology of sarcopenia is multifactorial and underlying mechanisms are currently not fully elucidated.
The etiology of sIBM is still unknown ; however , genetic factors , aging , lifestyles , and environmental factors may be involved.
The etiology of these abnormalities may be related to embryologic developmental arrest , aging or other comorbidities.
The etiology of this disease is not well defined yet.
The etiopathogenesis of this disease remains unclear.
The eukaryotic cell cycle is conventionally viewed as comprising several discrete steps , each of which must be completed before the next one is initiated.
The eukaryotic genome exists in vivo at an equimolar ratio with histones , thus forming a polymer composed of DNA and histone proteins.
The eukaryotic stress response involves translational suppression of non-housekeeping proteins and the sequestration of unnecessary mRNA transcripts into stress granules ( SGs ) .
The euploid oocytes come from young and healthy donors may overcome age associated endometrial receptivity defect.
The European Dementia Prevention Initiative ( EDPI ) , an international collaboration , encourages data sharing between different randomized controlled trials.
The European Innovation Partnership on Active and Healthy Ageing ( EIP on AHA ) has prioritized noncommunicable diseases ( NCDs ) .
The European League Against Rheumatism ( EULAR ) response was assessed after @number@ months of treatment.
The European Male Aging Study has demonstrated that the hypogonadism of male aging is predominantly secondary.
The EuroQoL visual analogic scale maintained its significant associations with SPPB , ADL and IADL , even after adjustment for potential confounders.
The EVA for typical surgical strabismus care is @number@.3B per yr.
The evaluation consisted of three phases.
The evaluation instruments had been the Berg Scale , Dizziness Handicap Inventory ( DHI ) and speech analysis.
The evaluation is performed using two different WBAN channel models.
The evaluation of ABI , and in particular TBI , typically requires significant technical skill and often involves referral to a vascular laboratory.
The evaluation of fall severity should be based on a standardized questionnaire and physical examination.
The evaluation of feasibility comprised training attendance , realised intensity of load , and perceived exertion.
The evaluation of monosaccharide compositions and proportions used gas chromatogram.
The evaluation of perceived health and quality of life is also significantly lower in the group of older prisoners.
The evaluation of their correct use represents a tool to verify the post analytical quality.
The evaluation of these symptoms requires measures of ocular and oral dryness.
The evaluation of this axis has moderate diagnostic validity as a screening tool to distinguish ET cases from those with dystonia.
The evaluation of TMD signs and symptoms was performed using the Fonseca Anamnestic Index ( IAF ) as to sociodemographic , systemic and otological factors.
The evaluation results show a preference for solely acoustic presentations or an acoustic presentation in combination with visual and tactile output.
The evaluations for disease were structured and uniform across time.
The evaluations of chromatic alteration through visual analysis and reflection spectrophotometry were carried out initially and after @number@ @number@ and @number@ hours of aging.
The evaluations of each informant seem to be influenced by their own emotional state and the inner experience of the effects of the disease.
The evaluation was based on subjects suffering from chronic lower back pain.
The evaluator needs to weigh not only factors related to the normal biological process of aging but also those that are attendant with the litigation.
The even fewer longitudinal studies indicate that iron accumulation may precede shrinkage of the basal ganglia and thus predict poor maintenance of cognitive functions.
The event created the platform to discuss the provision of medicines for older adults from a pharmaceutical sciences perspective.
The events observed in this model mimic those observed during senescence including thymus involution , i.e. enhanced glucocorticoid reaction to distress , and obesity.
The events occurring in meiotic prophase I are a prerequisite for proper chromosome segregation in the meiotic divisions.
The evidence about a direct relationship between tendinopathy and endothelial dysfunction is still poor.
The evidence as a whole suggests that exposure to insecticides is linked to increased risk of obesity and type @number@ diabetes.
The evidence base regarding the demography of aging with disabilities in the US is growing yet substantial gaps remain.
The evidence comparing different modalities of exercise is scarce and heterogeneous.
The evidence for all long-term outcomes was also of very low quality.
The evidence for an association between circulating microRNAs and diet is weaker because of a small number of studies.
The evidence for and against cosmeceutical use in patients with acne is reviewed.
The evidence for associations to mucous membrane irritation and atopic eczema ( manifestation , progression , exacerbation ) is classified as limited or suspected.
The evidence for efficient treatment ( the third perspective ) with analgesics is also limited , with few statistically well-powered trials.
The evidence for the use of ST as a countermeasure of abdominal obesity is less convincing.
The evidence for vitamin K supplementation in older adults is mixed.
The evidence from the qualitative studies demonstrated multiple positive effects of shared reading groups.
The evidence is presented via the four primary pharmacokinetic processes ( absorption , distribution , metabolism and elimination ) .
The evidence linking different oxidative stresses to the different types of cataracts is critically evaluated.
The evidence of an association with plasma beta amyloid could not be clearly demonstrated.
The evidence of the impact of retirement on the rate of decline in fluid cognitive abilities is conflicting.
The evidence on epidemiology , associated risk factors , treatment and hygiene measures were summarized.
The evidence on pharmacological and non-pharmacological ( exercise , nutrition , etc. ) interventions in older adults with arterial stiffness is promising.
The evidence on the nervous system does not provide evidence of premature aging as a result of SCI.
The evidences linking mTOR to energy and metabolic homeostasis included the following.
The evidence strongly supports that hypertension in the elderly is associated with an increase in stroke risk and cardiovascular mortality and morbidity.
The evidence suggests that the addition of elevated inflammation at the time of meniscal damage or meniscectomy results in an accelerated progression toward cartilage degradation.
The evidence summarized here strongly supports the consideration of PD as a disorder of cell metabolism.
The evidence supporting the administration of new targeted therapies in patients older than @number@ years is scarce and more research is needed.
The evidence that the DMT2 is regulated by a high number of genes , demonstrate the pathogenetic complexity of this disease.
The evidence we found regarding oxidative stress and autonomic nervous system might be seminal in RLS treatment.
The evidential value of this review is limited due to the lack of randomized , prospective studies.
The EVIDENT @number@ application integrates the information collected by the smartband on physical activity and the self-reported information by participants on daily food intake.
The evolutionarily conserved IGF-1 signalling pathway is associated with longevity , metabolism , tissue homeostasis , and cancer progression.
The evolutionary theories of aging are useful for gaining insights into the complex mechanisms underlying senescence.
The evolution is characterized by a change of systems and objects of the universe.
The evolution of magnetic susceptibility over this lifespan was found to display differential trajectories between the gray and the white matter.
The evolution of melatonin as an antioxidant by this organism was necessary as photosynthesis is associated with the generation of toxic-free radicals.
The evolution of the cognitive profile is a matter of debate , whether an eventual decline could be global or process-specific.
The evolving field of molecular pathological epidemiology has unique strength to investigate the effects of dietary and lifestyle exposure on clinical outcomes.
The ex1f-VNTR risk genotype was associated with AD in the total sample and at the second follow-up.
The exact causative factors have not been clearly defined , and development may result from structural disruptions in the connective tissue of the fasciae.
The exact cause of these very late stent thromboses is not clearly understood.
The exact function of autophagy in ovarian carcinoma is highly dependent on the circumstances of cancer including hypoxic , nutrient-deficient , chemotherapy and so on.
The exact interval recommended depends on the severity of the valve dysfunction and whether the patient is symptomatic.
The exact mechanisms underlying cataract formation are still unclear , but growing evidence suggests a potential role of inflammatory and oxidative processes.
The exact nature of pain ( amount or severity ) associated with in depression in the elderly population has not been studied extensively yet.
The exact nature of this relationship and its pathophysiology needs to be determined by further studies.
The exact role of microglia or other potentially infiltrating myeloid cells in different brain diseases is not fully understood.
The exact time point of the initiation is not well defined.
The exact underlying mechanisms are largely unknown , but enhanced mitochondrial biogenesis and preservation of mitochondrial function have been suggested to explain healthy ageing.
The examination begins on page @number@
The examination included visual acuity measurement , slit-lamp biomicroscopy , and optical coherence tomography.
The examination included visual acuity testing , slit lamp biomicroscopy , funduscopy and performance of a Schirmer test.
The examinations included a clinical investigation , brain neuroimaging , and a comprehensive neuropsychological test battery.
The examinations were performed using multifrequency transducers and low mechanical index.
The examination was performed with a Scheimpflug camera which enables to examine the anterior and posterior corneal surface separately.
The examined subjects were compromised for various reasons.
The exception was the action fluency task , where adults with Parkinson's disease performed most poorly.
The excessive properties have manifestations that accompany the enzymatic processes and may be not only irrelevant but even overtly adverse.
The excess mortality associated with hospital admission and lower disability scores is persistent at @number@ and @number@ years.
The excess of matrix proteins deposition was associated modestly with the activation of myofibroblasts and transforming growth factor-beta signaling pathway.
The excess risk in smokers increased with cigarette consumption in a dose-response manner , and decreased continuously with time since smoking cessation in former smokers.
The excess risk of incident dementia diminishes with time after stroke and may be higher in those without an APOE epsilon4 allele.
The excess risks of mental , physical , and social health outcomes highlight a need for more support directed toward spouses bereaved by suicide.
The excision ratio between malignant and benign skin tumours should be optimized.
The exciting realization that the retrograde response is embedded in the network of cellular quality control processes has emerged over the past few years.
The excluded categories were @number@ @number@ and @number@ ( service , transportation , and signage and identification ) .
The exclusion criteria included prior myocardial infarction , stroke , heart failure , atrial fibrillation , type @number@ diabetes mellitus , and pacing.
The exclusion criteria were obvious chest and spinal diseases.
The exclusion criteria will be people in need of institution-based rehabilitation or nursing home placement , and people who are terminally ill or cognitively reduced.
The exclusive attachment of the urethral sphincter to soft tissues implies dependence on pelvic-floor integrity for optimal function.
The excretion levels of urinary periostin were quantified with enzyme-linked immunosorbent assay.
The excursion of the centre of pressure and surface electromyogramme ( EMG ) of leg muscles were measured.
The excursions were not related to isokinetic truncal muscle power.
The execution rate was @percent@ , with an accuracy of @percent@.
The executive composite positively correlated with striatal volumes , and the working memory score negatively correlated with disease burden.
The executive functions were correlated with the priming task only in the elderly participants.
The executive , left and right frontoparietal resting-state ( RS ) networks showed age-related increases in RSFC.
The exercise challenges consisted of inclined treadmill brisk walking ( 60min , 68-69% V˙O2peak ) .
The exercise group completed @number@ weeks of aerobic exercise training.
The exercise group completed @number@ wk of moderate aerobic exercise training.
The exercise group , in contrast , perceived physical capacities as maintained or improved.
The exercise groups underwent a program for lower-limb muscle endurance that consisted of 40-minute sessions twice a week for six weeks.
The exercise intervention consisted of combined aerobic and resistance workouts scheduled @number@ days / week for @number@ minutes / day.
The exercise intervention enhanced indices of executive function , although memory , mood , and functionality were not affected.
The exercise intervention successfully increased fitness and resulted in a greater fall in cortisol concentration from peak to midday , compared with the control group.
The exercise program included measurements of radial artery blood flow waveform for different age groups using a noninvasive optical sensor.
The exercise program included strength and balance training and the 8-form Tai Chi Chuan.
The exercise required them to grip intermittently at @percent@ maximum handgrip strength until voluntary exhaustion.
The exercises were effective to improve preferred and fast gait speed.
The exercise volume was equal in both interventions ( @number@ weeks , two times per week and ∼ @number@.5h per session ) .
The existence of a DPC protease in higher eukaryotes is inferred from data in Xenopus laevis egg extracts , but its identity remains elusive.
The existence of an SIS in a particular modality was not associated with the presence of a PP in the same modality.
The existence of cayenne could not be detected by chest CT in any of the patients.
The existence of HOAs is not , in itself , sufficient to account for the myopia epidemic in China.
The existence of microrelief had an effect on the suppression of dermal buckling.
The existence of novelty is thus confirmed with a different method across a wide variety of participants.
The existence of RAS gene polymorphisms and inflammatory cytokines may further potentiate susceptibility to renal disease in Indigenous Australians.
The existing data encourages to look for new treatment methods for CHF , replacing or enhancing traditional ones while constituting a low nuisance for patients.
The existing evidence suggests that psychosocial needs such as the need to engage in daily individualized activities and care must not be ignored in LTC.
The existing health care response to frailty is mainly secondary care-based and reactive to the acute health crises of falls , delirium and immobility.
The existing male-unfriendly health-care system and the negative influence of masculinity on men's health behaviour must be addressed.
The existing Older Adult Mental Health ( OAMH ) liaison service was increasingly unable to meet the escalating needs of older and frail patients.
The existing physician shortage is heightened by the high percentage of doctors reaching retirement age.
The existing standard values are defined for younger adults ; however patients have predominantly an older age.
The EXIT25 was the primary measure examined.
The EXIT and Quick EXIT should be considered to be measures of global cognitive function rather than pure ECF measures.
The expansion of the aging population , residential care facilities , and projected registered nurse shortages pose significant challenges to nurse staffing ratios.
The expectations for therapy also change with age.
The expectations of both parties must be clearly stated and donor safety must remain the top priority.
The expectations of drug treatment effects were not statistically significantly influenced by any variables considered about the patients or the caregivers.
The expectation was a significant postural effect with the standing condition , as evidenced by reduced overestimation.
The expected rearrangements at immunoglobulin , T-cell receptor and BCL2 loci were detected in DNA samples by all laboratories.
The expected reciprocal relationship between different biomarkers was verified by structural equation modeling.
The experience of aging is discussed in the context of Puerto Rico's history and continued dependence on the United States.
The experience of death and dying is very different in the 21st century than it was in the 19th.
The experience of dementia is raises many important questions about the nature of self and personhood.
The experience of depression is diverse based on social locations and context.
The experience of pain and disease symptoms diminished significantly in both sexes ( p < 0.001 ) .
The experience of primary care seldom appeared to move beyond a label of arthritis and an unwelcome emphasis on pharmacologic treatment.
The experience of the psychological present is known to differ according to psychological state and cognitive processes , such as attention.
The experiences initiated by the University of Stanford , or in Spain by the National Patients ' Forum , could serve as models.
The \ "experiencing aging \ " intervention was associated with improvement in empathy but worsening of attitude.
The experimental cement showed less CS reduction and higher antibacterial activity than Fuji II LC.
The experimental data were then fitted with a Fung-type constitutive model.
The experimental design also comprised breaks with various durations.
The experimental group applied a Lycogen ( TM ) -containing skin care product via sonophoresis in the same time schedule.
The experimental group completed a 3-month EXDASE program.
The experimental group did not exhibit a higher PAM blood level than did the control group.
The experimental group participated in a supervised creative dance program for @number@ weeks.
The experimental group received intervention consisting of a 12-week support group for dementia caregivers.
The experimental groups carried out @number@ weeks of an excise program performed on water or on land.
The experimental group showed significant improvement in the task as a result of training whereas the older control group showed no significant improvement.
The experimental groups showed an increase in slots and erosions on the surface of the enamel and were more pronounced in Group @number@
The experimental group will be offered reablement and the control group offered standard treatment.
The experimental phase included data collection and then sharing the results with the case managers.
The experimental primers together with the control group were applied onto acid-etched premolars for attachment of orthodontic brackets.
The experimental results demonstrated promising performance ( @percent@ F-measure ) .
The experimental results showed that the proposed method generated smooth surfaces with less volume differences and better shape similarity to input volumes than others.
The experimental results showed that the selected voxels may be categorized into two components according to the two steps in the proposed method.
The experimental results show that real-time music biofeedback according a user's EEG feature may positively improve the user's attention state.
The experimental results show that the proposed system may provide an on-line fatigue monitoring and analysis for the lower extremity muscles during cycling movement.
The experimental results suggested that skin irritation caused by coumarins was mainly derived from the analogs but not from coumarin itself.
The experimental task was to provide old / new recognition and confidence rating judgments.
The experiment group was administrated with α-lipoic acid , while only Vitamin C for the control group , for @number@ consecutive weeks.
The experiments are performed on the two publicly available iris aging databases namely , and ND-TimeLapseIris-2012 using a commercial matcher , VeriEye.
The experiments showed that PTH increased calcified callus tissue and torsional strength with a greater response in young mice.
The experiments show that cells are very heterogeneous with respect to inclusion formation and so we use stochastic simulation.
The experiments suggest that the proposed algorithm can outperform a popular commercial system and evaluates them against humans in matching disguised face images.
The experiments we carried out in human primary skin fibroblasts.
The experiment was comprised of four conditions and we looked at two situations that involved a social context and non-social ( solitary ) context task.
The expert panel identified @percent@ with delirium , @percent@ of whom had hypoactive or normal psychomotor features.
The expert panel included geriatrician , epidemiologist , neurologist , psychiatrist , psychologist , ICT engineers , representatives from the industry and patient association.
The experts were also requested to suggest additional substances and indication areas for assessment and possible inclusion in the FORTA List.
The explanation for this phenomenon is unclear.
The explanation of these universal mechanisms by tracing survival curves of model organisms clearly suggests that death of individuals is a direct consequence of aging.
The explants were analyzed quantitatively by light microscopy and scanning electron microscopy.
The exploration of frailty as a pre-disability geriatric condition represents one of the most promising research arenas of modern medicine.
The exploration of the subthemes revealed that the decision-making process is often reported as an interrelated experience by the couples and as a dyadic stressor.
The exploratory factor analysis confirmed the existence of a unique factor structure that explained @percent@ of the variance.
The exploratory factor analysis revealed five main latent components of social network with one component composed of hierarchical part.
The exploratory principal component analysis with varimax rotation revealed RS-CN to have a four-factor structure.
The exposure of radiologists and other medical workers to medical treatment radiation may thus be increased.
The exposure-response function was nonlinear for averages of temperature , presenting a J-shaped pattern , suggesting greater risk at lower and higher temperatures.
The exposure variables were the baseline serum IL-6 and CRP levels measured by ELISA.
The exposure variable was age and the outcome variables were UEI incidence and severity.
The expression and activities of MMPs are regulated by signaling molecules , TIMPs , cell surface receptors and transcription factors.
The expression and distribution of Wnt components in different organs vary with age , which may have important implications for preserving tissue homeostasis.
The expression levels depended on the animal strains or cell status.
The expression levels of Ac-histone H3 , HDAC1 , HAT1 , p300 and SIRT1 were increased in HT1080 cells treated with spermine.
The expression levels of both CyPA and CD147 were increased with increase in age.
The expression levels of circRNA 100269 and its linear isomer LPHN2 mRNA were found to be downregulated ( p < 0.01 ) in GC tissues.
The expression levels of Col I , Col III , TIMP-1 , TIMP-2 and MMP-1 mRNA were detected with RT-PCR.
The expression levels of DNA repair genes were evaluated by microarray analysis.
The expression levels of mRNA or proteins for enzymes are as low as 1 / 200 - @date@ @number@
The expression levels of MTH1 in the hippocampi of 8- and 12-month-old SAMP8 mice were significantly lower than those of control mice.
The expression levels of TGF-β1 , IL-10 , IL-17A and RANKL mRNA in periodontal tissues were detected by real-time quantitative PCR.
The expression levels of the genes were evaluated by xx genes microarray analysis.
The expression levels of these genes must be fine-tuned in the brain to keep Aβ at a balanced amount under physiological condition.
The expression levels of these two proteins and their aggregation processes are modulated by reactive oxygen radicals and transition metal ions in a similar manner.
The expression of active-caspase-3 was parallel with that of SSTR1 in a time-dependent manner.
The expression of aldehyde oxidase @number@ was measured by real-time polymerase chain reaction.
The expression of all three proteins was significantly correlated with each other ( P < @number@ and r > @number@ respectively ) .
The expression of AQP4 is preserved in MS lesions losing myelin basic protein ( MBP ) positivity.
The expression of cleaved caspase-3 , appoptosin , heme oxygenase-1 ( HO-1 ) was examined using Western blotting.
The expression of COL1A1 , COL3A1 , MMP1 , MMP2 , MMP3 , and MMP9 genes was determined by qRT-PCR.
The expression of extracellular matrix ( ECM ) genes was determined using quantitative polymerase chain reaction.
The expression of GPRC5C was analysed by RNA-sequencing , qPCR , western blotting and confocal microscopy.
The expression of growth factors and matrix-related genes were unaffected by NSAID.
The expression of heme oxygenase-2 was markedly increased in the sunlight-exposed skin compared with the sun-protected skin.
The expression of ICAM-1 mRNA was examined by RT-PCR and the expression of p53 and p21 was examined by western blot analysis.
The expression of immunomodulation-related genes was detected by RT-PCR.
The expression of long non-coding RNAs ( lncRNAs ) is dysregulated in non-small cell lung cancer ( NSCLC ) .
The expression of LRP1 as well as smLRP1 is decreased in HNSCC cell lines in comparison to healthy mucosa.
The expression of macrophage phenotype markers was investigated with real-time polymerase chain reaction.
The expression of MCP-1 , IL-8 and IL-6 ( which are traditionally classified as ' pro-inflammatory' ) increased substantially after acute exercise.
The expression of miR-124 increased in UVB-irradiated NHEKs compared to controls in a dose-dependent manner.
The expression of miRNAs in plasma may be indicative of presence of CRC.
The expression of MMP-7 , c-Jun and c-Fos were detected using the immunohistochemical method.
The expression of monocyte surface markers was compared between tuberculosis patients with and without type @number@ diabetes ( DM2 ) .
The expression of most activating components starting at C3 was low.
The expression of NOS isoforms in embryonic tissues is temporally and spatially regulated , and disruption of endogenous NO can lead to developmental defects.
The expression of orexin is induced by hypoglycemia , low food , pregnancy , and hemodialysis.
The expression of p400 was measured by immunohistochemistry using a tissue microarray containing tumor tissue samples from @number@ RCC patients.
The expression of PCNA and Ki-67 showed the same trend.
The expression of PDHK1 , a major isoform of PDHKs in cancer , was not affected by ARE treatment.
The expression of phosphor-PDH , PDH and PDHK1 were measured by Western blot analysis.
The expression of Prdm13 in the hypothalamus increased under diet restriction , whereas it decreased during aging.
The expression of protein and RNA were detected by Western blot and Reverse polymerase chain reaction.
The expression of the ( G4C2 ) 102 repeat produces RNA foci and also undergoes RAN translation.
The expression of the hPER1 gene at @number@ h was determined from oral mucosa cells by relative quantification using h36B4 as house-keeping gene.
The expression of the INK4A-ARF-INK4B gene cluster is silenced by polycomb during normal cell growth and is activated by oncogenic insults and during aging.
The expression of the p16 ( INK4α ) is primarily under transcriptional control.
The expression of these receptors is reduced during CKD.
The expression of truncated tau alone induced significant mitochondrial fragmentation in neurons.
The expression of VASH1 has been shown in endothelial cells ( ECs ) in both physiological and pathological conditions associated with angiogenesis.
The expression of xanthine oxidase ( XO ) and manganese-superoxide dismutase ( Mn-SOD ) was assessed by Western blotting analysis.
The expression of α-Klotho and FGFR1 in the parathyroid tissue was detected using immunohistochemical staining.
The expression of α-Klotho decreased further with increasing parathyroid pathology.
The expression of α-secretase and β-secretase was slightly altered in the transfected cells , but the activities of α-secretase and β-secretase were not significantly altered.
The expression of α-smooth muscle actin ( α-SMA ) , p21Waf1 / Cif1 , γ-H2AX , and IL-6 was investigated by immunohistochemistry or immunofluorescence.
The expressions of MMP-1 and TIMP-1 were related to patients ' age and degree of degenerative changes.
The expressions of MMP-1 and TIMP-1 were strongly correlated to the age and the degree of the degenerative changes.
The extended impact is attributed to associated brain pathology.
The extended model was adopted to include the measurement of the exposure of interest throughout the follow-up period and not only at baseline.
The extension is linked to the core domain by a salt bridge and two hydrophobic patches.
The extension of life expectancy is a global phenomenon.
The extension of life span by caloric restriction has been studied across species from yeast and Caenorhabditis elegans to primates.
The extent and magnitudes of their differential effects on the metabolic syndrome ( MetS ) are still unknown.
The extent of bladder dysfunction in chronic bladder ischemia may depend on the degree and duration of ischemia.
The extent of damage was directly proportional to the duration of exposure.
The extent of DNA damage was assessed with respect to the duration of exposure.
The extent of DNA damage was measured as plasma 8-OHdG.
The extent of engagement of familiarity and recollection processes during associative retrieval was estimated by using event-related potentials ( ERPs ) .
The extent of insomnia symptoms exhibited a positive , dose-response relation with risk of falling among those not using sleep medications.
The extent of IVDD was evaluated by macroscopic grading , histopathology , glycosaminoglycan content , and matrix metalloproteinase @number@ activity.
The extent of lipid peroxidation in form of malondialdehyde was measured by thiobarbituric acid method.
The extent of matrix mineralization was measured by Alizarin Red S staining.
The extent of oxidized Trp ( N-formyl kynurenine ) in HGC due to cataract formation was determined , primarily using fluorescence spectroscopy.
The extent of sarcopenia judged by the muscle / bone ratio was approximately twice that determined when normalising to height squared.
The extent of subtelomeric methylation of long telomeres tended to correlate negatively with the telomeric attrition.
The extent of such damage is inversely related to constitutive skin pigmentation.
The extent of such resource use , and associated costs , are not fully understood.
The extent of that effect varied across AHRS.
The extent of the impairment in metabolism was classified as absent , mild , medium or strong.
The extent of the improvement of extra-hepatic manifestations in the elderly with SVR is also unclear.
The extent of their utilisation being unknown may result in the prescription of standard wheelchairs.
The extent of the latter increase was correlated with symptom severity.
The extent of theory use and intervention effectiveness in terms of adherence and clinical / humanistic outcomes varied across studies.
The extent to which age-related changes in cognitive and motor function affect the ability to imitate speech is poorly understood.
The extent to which age-related changes in early visual processing contribute to impairments in selective attention remains to be determined.
The extent to which Aβ-related effects occur outside of the DMN and between networks remains unclear.
The extent to which deficits in specific cognitive domains contribute to older drivers ' safety risk in complex real-world driving tasks is not well understood.
The extent to which heterozygosity at the WRN locus may modify the effect of biallelic SAMHD1 mutations is unknown.
The extent to which IIVRT is an independent predictor of mortality , however , is unclear.
The extent to which individual younger adults suppressed competitors predicted their performance on a memory span task.
The extent to which social relationships influence cognitive aging is unclear.
The extent to which the age-related decline in regional brain glucose uptake also applies to other important brain fuels is presently unknown.
The extent to which the neurotoxic effects of drugs of abuse influence subsequent drug seeking behaviors and impulsivity is an understudied area of research.
The extent to which there are subgroups of older adults whose moods are less positive , however , is unclear.
The extent to which these associations are present in other study populations is unknown.
The extent to which these cardiovascular changes influence human fetal and neonatal cardiac adaptation has not been fully elucidated.
The extent to which these recommendations can create change depends greatly on our researcher colleagues.
The extent to which they may reduce negative aspects of SWB may be unequally distributed across educational groups.
The extent to which this alteration is a cause or effect of WS disease phenotypes remains unknown.
The extent to which this control relies upon optic flow , visual direction cues or non-visual sensory inputs has long been debated.
The extent to which this translates to disparities in brain structure is unclear.
The extent to which WMH location relates to cognitive performance has received less attention , but is likely to be functionally important.
The extracellular domain could be cleaved off and released into the systemic circulation.
The extracellular domain of Klotho can be enzymatically cleaved off and released into the systemic circulation where it acts as β-glucuronidase and a hormone.
The extracellular domain of Klotho is cleaved and released in the blood stream , where it may function as a vasculoprotective hormone.
The extracellular domain of Klotho protein is subject to ectodomain shedding and released into the blood and urine.
The extracellular matrix of the dermis is a complex , dynamic system with the various dermal components undergoing individual physiologic changes as we age.
The extracellular volume fraction ( ECV ) was derived accounting for the hematocrit level.
The extra costs for introducing structural attention to work in healthcare are estimated at 2-3 Euros per employee.
The extracranial venous system is complex and variable between individuals.
The extract at @number@ mg / ml exhibited the highest MMP-2 inhibition of @number@ ± @percent@.
The extracted data were assessed based on the importance of the determinants , the strength of evidence , and the methodological quality.
The extracted data were assessed on the importance of determinants , strength of evidence and methodological quality.
The extracted respiratory signals may be influenced by several technical and physiological factors.
The extraction of a proxy for the respiration signal from a recorded electrocardiogram ( ECG ) signal has therefore received considerable interest from previous researchers.
The extract is from the natural biomaterial of the mushroom which is rich in polysaccharides , including β-glucan.
The extracts ( at @number@.001-10 mg / ml ) were tested for antioxidative and tyrosinase inhibition activities using a colorimetric method.
The extracts obtained this way from the plant stem cells are currently used for production of both common or professional care cosmetics.
The extracts were determined for total phenolic and flavonoid contents.
The extracts were evaluated based on tea quality control tests , UV , IR scans , and in vitro antioxidant capacity tests.
The extra demand in sulfur amino acids led to a consumption far above the corresponding population-safe recommendation.
The extragenital manifestation of Chlamydia trachomatis infection frequently results in non-specific conjunctivitis among sexually active adults.
The extramacular and temporal retina showed higher response amplitude and faster response latency when compared with the macular and nasal retinae , respectively.
The extraoral scars were almost imperceptible.
The extreme form of reproductive aging is primary ovarian insufficiency ( POI ) with prevalence ranging from @number@ to @percent@ of the female population.
The extreme risk in this subgroup may arise from the preexisting burden of cerebral ischemic disease.
The eyebrow is simple to regard , but complicated to understand.
The eye fissure frame ratio of modern idealized female portraits was similar to that of beautiful female portraits idealized by classical artists.
The eye is a sensitive organ with complex optical system involves in the perception of light.
The eye lens crystallins represent an ideal target for studying the effects of aging on protein structure.
The eyelid laxity improved , and no complications occurred.
The F388L mutation locates adjacent to the critical catalytic aspartate site ( D385 ) of PS1.
The FaB-FC also demonstrated high internal consistency ( α = @number@ ) .
The FaB-FC could also be useful in guiding fall prevention interventions and measuring the impact of these interventions on seniors ' behaviors.
The FaB-FC is a relevant complementary assessment tool for identifying seniors at risk for falls.
The fabricated smart sensor tag module has an operating range of up to @number@.5m and conducting in real-time activity and falling detection.
The face appears as a single dynamic structure with a smooth contour and very little if any shadowing between different anatomical regions.
The faces could be negative , positive , or neutral.
The face , seen as a unitary region is subject to the gravitational force.
The faces of the twins in these images were swapped creating two new images per twin pair ( @number@ images in total ) .
The face specific decline in older adults revealed deficits in handling internal facial features , while young adults matched external and internal features equally well.
The face-to-face interactions of infants and their parents are a model system in which critical communicative abilities emerge.
The facet of Sadness exhibited the largest age-group difference , relating more to guilt and anxiety in older than younger adults.
The facial skin of @number@ women , aged 18-80 , living in Shanghai , was investigated over two successive 6-month periods , summer and winter.
The facilities ' practice of filling the bed quickly was most often experienced as negative.
The facilities were provided with a written educational toolkit and shared information through an e-mail distribution list.
The factor analysis showed that the severe group was expanded to D3P1 and D3P2 in the revised CREDOS ischemia classification system.
The factorial structure of the scale was examined using confirmatory and exploratory factor analysis.
The factorial structure of the test is essentially one-dimensional and the item discrimination indices are high , with values between @number@ and @number@
The factor labelled ' Free spirits ' posits the dominant view of freedom.
The factor means showed substantial decrements with increasing age.
The factor most consistently associated with current and future walking ability is leg speed.
The factors affecting the health , aging and longevity are discussed.
The factors associated with ADL performance were analyzed with adjustment for age , gender , Charlson's comorbidity index and Kellgren-Lawrence score.
The factors associated with mortality were specifically analyzed with multiple logistic regression models.
The factors associated with PIMs use were age , osteoporosis , Alzheimer / dementia , diabetes , and alcohol consumption.
The factors associated with such phenomena are yet to be elucidated.
The factors associated with survival were investigated separately for men and women by Cox regression with , as much as possible , time-dependent variables.
The factors causing increased CD33 expression by microglia in brain are still unclear , although both genetic and disease factors are involved.
The factor scores for manual dexterity declined significantly with increasing age.
The factors focused mainly on lifestyle , physical condition , and the model was adjusted for age and gender.
The factors influencing anxiety and depression in patients were aging , independence , problem-solving ability , and NYHA functional class.
The factors influencing healthy aging were depression , leisure activities , perceived health status , ego integrity , and self-achievements.
The factors of school limiting concerning formation of somatic and mental properties of schoolboys are surveyed.
The factors predicting non-persistence were identified in the Cox proportional hazards model.
The factors that determine the age of onset currently remain unexplained.
The factors that were statistically significant ( p < @number@ ) predictors of both onset of overweight and obesity were income , ineffectiveness and race.
The factor structure showed stability over the two-year period.
The factors underlying the sex differences in AD are not well understood.
The factors used were : age , sex , postal c ode , and date of visit.
The factor variances were on most parts equal across age groups.
The fact that aging affects the capacity to attune sets a new line of research in the study of perception and perceptual-motor skills of elderly.
The fact that awareness is not strongly associated with healthy behaviours suggests that antihypertensive medication is not accompanied by non-pharmacological therapies.
The fact that not only energy intake but also REE are decreased brings a new insight on catabolic situations.
The fact that resource-rich postindustrial societies have a very low prevalence of iron-deficiency anemia offers hope that common types of anemia can be eliminated.
The FAERS database contains @number@ reports from @date@ to @date@ .
The failure load and type of the bonded restorations were evaluated by applying axial load to the pontic.
The failure of clearance mechanisms to eliminate Aβ from the brain contributes to the development of sporadic CAA and AD.
The failure of healthcare professionals to recognise and respond to who older patients are aside from their illness exacerbate the experience of disruptions.
The failure rate was @percent@.
The failures appeared to be of a mixed nature , although aging caused more areas of cohesive than adhesive failure in all groups.
The failure to control gait speed may account for this lack of agreement.
The failure types were evaluated after debonding.
The FA index predicted change in functional status , future need of nursing care , and mortality in an unselected population of community-dwelling seniors.
The fall in LDL-apoB was caused by an @percent@ increase in LDL-apoB FCR and a @percent@ reduction in LDL-apoB PR.
The fall in testosterone levels with age appears to be a real phenomenon.
The fallopian tube epithelium ( FTE ) is one of the progenitor populations for high-grade serous ovarian cancer ( HGSC ) .
The fall rate was evaluated for @number@ years.
The fall risk awareness questionnaire did not predict incident falls or injurious falls.
The Falls Efficacy Scale was used to quantify fear of falling.
The families predominantly manage AD patients.
The family and the State play a basic role in the construction of care systems and in the establishment of strategies to access care resources.
The family caregiver's utility was @number@ at baseline and significantly decreased to @number@ ( p-value = @number@ ) when their children were hospitalized with diarrhea.
The family cohort consisted of parents of age @number@ or above and their children ranging in age from @number@ to @number@
The family physician has the social obligation to research and promote health , to fight diseases.
The FAS equation detects higher rates of CKD than MDRD and CKD-EPI , which are most widely used at present.
The FAs in these regions have a strong negative correlation with age.
The fasting plasma glucose and glycated hemoglobin ( HbA1c ) was measured every 3-6 months.
The fast pathway ERP was significantly longer in group @number@ than in other groups , and was associated with the largest tachycardia window.
The fatality rate of prosthetic valve endocarditis ( PVE ) remains stable over the years , in part due to the aging of the population.
The fat compartments surrounding the facial folds could be defined in each subject.
The fate of the bioactive depends on its physicochemical properties and the location of its release.
The fatigue strength was improved compared to irradiated and melted UHMWPEs crosslinked using the same irradiation dose.
The fatiguing exercise , performed on a dynamometer , consisted of maintaining an isometric contraction of the plantarflexors at @number@ % of maximum until exhaustion.
The fat mass ( FM ) and %FM for both CA and BA were significantly higher than zero at baseline.
The favorable anti-atherosclerotic effect of carotenoids was also demonstrated in cross-sectional population studies showing a positive correlation between low carotenoid levels and adverse cardiovascular outcome.
The favorable effects associated with SWB have prompted new research aimed at raising happiness and wellbeing through individual interventions and public health initiatives.
The F-box DNA helicase @number@ ( FBH1 ) is a @number@'@number@ DNA helicase with a putative function as a negative regulator of HR.
The FCP induced differential expression of genes and proteins is associated with stress response pathways.
The FCPP generated a non-partisan grassroots effort to educate and motivate policymakers to address caregiving issues and solutions.
The FCR of apo ( a ) tended to increase ( @percent@ ) without any change in apo ( a ) PR.
The FCSRT assesses verbal learning and memory.
The FDA continues to focus on routine post-marketing surveillance monitoring of reported adverse events.
The FD measures revealed relatively higher association with age among women than men , but not as strong as MCW.
The fear that testosterone treatment of elderly men would lead to prostate disease has not been substantiated in studies.
The feasibility of implementation of the QI set and inter-rater reliability were determined.
The feasibility of supervised exercise training in individuals with small AAA remains unclear.
The feasibility of this approach has been shown in demonstration projects.
The feature of risk factors for cardiovascular disease may be affected by both sex hormone and sex related genes.
The febrile period of the ABPC / SBT group was significantly shorter than that of the AZM group ( P = @number@ ) .
The fecundity of women decreases gradually but significantly beginning approximately at age @number@ years and decreases more rapidly after age @number@ years.
The fecundity of women decreases gradually but significantly beginning approximately at age @number@ years and decreases more rapidly after age @number@ years.
The federal government currently employs four food and nutrition programs that target the senior population in an effort to address their specific needs.
The feeling of knowing ( FOK ) task allows measurement of the predictive accuracy of this reflective judgement.
The feldspathic ceramic showed the highest values of ΔE00.
The female cardioprotective advantage , present in mammals of a reproductively competent age , is lost during the transition to a postreproductive state.
The female group had an age-associated negative correlation of FDG uptake only in the right corpus callosum.
The female participants ' views on adapting to home , planning for their elderly years , and views on growing older are also explored.
The female prevalence ( @time@ % , 95%CI : 9.95%-14.94% ) was higher than male prevalence ( @percent@ , 95%CI : 5.94%-9.43% ) .
The female sexual quality of life questionnaire improved in the 100M-group ( p = @number@ ) .
The female susceptibility for AD has been largely associated with the loss of ovarian sex hormones during menopause.
The femoral cartilage was divided into weight-bearing ( WB-P ) and less-weight-bearing ( LWB-P ) portions.
The femur was the most frequent fracture site.
The few Danish studies are more difficult to compare , with conflicting results arising in the analysis.
The FFMI curve showed a very modest exponential increase with age.
The FGF23-Klotho endocrine axis is a pivotal regulator of mineral metabolism.
The FHBM was determined to represent a 53-59 YO mid-sized male.
The FHC will make it possible to discriminate between the effects of aging and radiation on this biomarker.
The FI better predicted mortality than did the metabolic syndrome , regardless of age.
The fibre angles at the mid-substance of the muscle were recorded.
The fibroblasts and ADSCs were isolated from human tissue and cultured.
The fibroblast was used for collagen synthesis and MMP-1 , @number@ @number@ inhibition tests on herbal extracts.
The fidelity of the program also has been maintained by implementing an instructor certification program and standardizing program content and delivery.
The field of cartilage repair has exponentially been growing over the past decade.
The field of evolutionary demography has long focused on understanding the evolution of senescence while largely failing to address the evolution of ontogenescence.
The field of learning and memory is becoming particularly interested in understanding the cognitive influence of epigenetics.
The field of nutrition has evolved rapidly over the past century.
The field of psychiatric genetics is hampered by the lack of a clear taxonomy for disorders.
The field of redox proteomics focuses to a large extent on analyzing cysteine oxidation in proteins under different experimental conditions and states of diseases.
The field of stem cell therapy has emerged as a promising research area for brain repair.
The field study began in @date@ .
The fieldwork for the first and second waves of CRELES was conducted from @number@ to @number@ and from @number@ to @number@ respectively.
The fifth percentile of age- , sex- , and body mass index-stratified reference values were used as cut-off.
The figure can be manipulated with certain interaction functions to display more detailed information.
The figure of Schirmer I test and BUT decreased in elder people , at the same time the scores of Fl and MGD increased.
The figures at @number@ weeks and @number@ months were @number@ ( @percent@ ) and @number@ ( @percent@ ) patients , respectively.
The figures depict an age where the human population has a minimal risk of death from biological causes.
The FI-Lab can be applied as a single frailty measure or in combination with / in addition to other frailty instruments.
The FI-lab determined on admission for trauma may not be useful.
The FI-Lab was correlated with all the other frailty instruments ( all CONCLUSION : The FI-Lab showed key characteristics of an FI.
The filler was administered in the preperiosteal tissues.
The final analysis included @number@ children with BMI in normal range for age.
The final analysis included @number@ participants.
The final choice was made by an expert committee.
The final consequence is the accumulation of highly cross-linked undegradable aggregates such as lipofuscin.
The final database included about @number@ posts.
The final data set included @number@ younger adults ( YA , age < 65 ) and @number@ older adults ( OA , age≥65 ) .
The final decision was made by patients.
The final diagnosis depends ultimately on pathological biopsy , and thoracoscopy is the most effective method to confirm DLBCL.
The final diagnosis was adjudicated by a study-independent physician.
The final diagnosis was adjudicated by two independent cardiologists.
The final follow-up visit was on @date@ .
The final global meta-analysis across discovery and replication data sets comprised @number@ AN cases and @number@ @number@ controls.
The final hallmark of diminishing ovarian reserve is menopause , a state known to be inextricably linked to the deterioration of female cardiovascular health.
The final model has a mean prediction error of @number@ a mean squared error of @time@ , and a coefficient of correlation of @number@
The final model included age , weight , total cholesterol , heart failure , valvular heart disease , and antihypertensive treatment.
The final Model @number@ revealed a different relationship between recovery-stress factors and performance.
The final model revealed a statistically significant association between FI and functional and cognitive impairments.
The final model specification includes an intercept and spatial components ( structured and unstructured ) .
The final model was applied to an independent dataset containing genotype and PSA screening data.
The final neurological assessment determined the degree of developmental disorder.
The final plate counts were @number@ and @number@ log CFU / cm ( @number@ ) for dry and wet aged samples , respectively.
The final regression model explained about @percent@ of variance of depression in the sample.
The final sample consisted of @number@ elderly , mostly females , with mean age of @number@ years.
The final sample included @number@ subjects with complete data and without chronic disease at baseline.
The final sample involved @number@ participants recruited in three Canadian cities between @number@ and @number@
The final sample size for the analysis was @number@ participants.
The final search query was run in MEDLINE / PubMed , CINAHL Plus , ISI Web of Science and Scopus.
The final section contains several suggestions concerning measurement and methodology that may lead to stronger conclusions in the future.
The final section of the review is devoted to a consideration of pharmacological , anti-inflammatory strategies with adjunctive potential in the antimicrobial chemotherapy of CAP.
The final stage of phenoptosis can be represented by endothelium dysfunction related with oxidative stress , insulin resistance , and the most prevalent cardiovascular pathologies.
The final study population consisted of @number@ women.
The final TAT-Cygb had a molecular weight of @number@ kDa with @percent@ purity , as shown by SDS-PAGE.
The final three clinical measures reflect compromised vision , little interest or pleasure in things normally enjoyed , and diarrhea.
The financial constraint was the main pushing factor for the retiree to go to paid work.
The financial rationale for embarking on this quality journey is clear ; applying it to today's health care remains challenging.
The financing scheme of the aged was concentrated on social health insurance and family health expenditure.
The finding also indicates gender differences.
The finding demonstrates the particular importance of social engagement within the facility for those with reduced physical function.
The finding illustrates that the burden of old people is still heavy.
The finding needs to be reproduced in additional cohorts to assess its generalizability.
The finding of a resource-dependency of this positivity effect suggests demanding self-regulating processes that are related to emotional well-being.
The finding of aspirin benefit at low-doses used for cardioprevention , locates the antiplatelet effect of aspirin at the centre of its antitumour efficacy.
The finding of focal diminished bone mineral density of the greater tuberosity in the absence of rotator cuff tears warrants further investigation.
The finding relies on the fact that vascular and valvular calcifications are predictors of cardiovascular diseases and mortality in persons with chronic renal failure.
The findings also call for the creation of particular guidelines for primary prevention of SCC.
The findings also demonstrate that perceived age is a better biomarker of skin , hair and facial aging than chronological age.
The findings also highlighted the developmental trajectories of depressive symptom in terms of their related factors in the elderly.
The findings also highlight the diversity of residential care communities across different sizes.
The findings also highlight the diversity of residents across the different sizes of residential care communities.
The findings also highlight the need to examine the mechanisms of group-referencing that can lead to variability in the group-reference effect.
The findings also illustrate that licensure and certification of home health agencies may enhance the capacity for improvements in quality of care.
The findings also indicate that there is no consensus on the definition of quality of life or its domains structures.
The findings also provide evidence of the potential of the So-Moral as a developmentally appropriate measure of MR throughout childhood and adolescence.
The findings also revealed good reliability for BOLD magnetic resonance imaging in OA for the soleus and anterior compartment muscles.
The findings also suggest , but do not prove , a beneficial effect of lung protective strategies using adoptively transferred MSCs in ARDS.
The findings also suggest that a focus on the present orientation before and following admission and on staff-to-resident communication may be beneficial.
The findings also suggest that clients embedded in restricted networks are at high risk for negative outcomes.
The findings are also projected to pave the way for major investments in the field of disability prevention in old age.
The findings are discussed in context of neurobiological processes known to be involved in brain maturation , including synaptic reorganization , pruning and myelination.
The findings are discussed in relation to social , emotional , and cognitive changes with age.
The findings are discussed in relation to the stereotyping of older people and transformed into hypothetical statements to be modified in future research.
The findings are discussed in terms of compensation theory , whereby planning is a key compensatory resource for fine motor control in older adults.
The findings are discussed in terms of their implications for the clinical management of ED post-surgery and helping men adjust to life following treatment.
The findings are even more promising because future generations of family caregivers will be more familiar with the Internet.
The findings are explored in relation to ideas about health care delivery associated with neoliberalism.
The findings are interpreted in the context of the bilingual advantages in attention and executive functions.
The findings can be interpreted as reflecting major differences in task demands and underlying control mechanisms.
The findings confirmed the importance of considering the role of metacognitive attitudes of older adults in memory training activities.
The findings could have important implications for China to develop and target community health programs to improve self-perceived usefulness among older adults.
The findings demonstrated an absence of the bilateral deficit for children , but not for younger and older adults.
The findings demonstrate that culture and ethnicity affect health evaluations and caregiving decision making.
The findings demonstrate that the driving mobility of older people is influenced by state relicensing policies.
The findings demonstrate that the importance of sleep duration for daily affective well-being is better understood when considering the age of the sleeper.
The findings demonstrate the importance of autonomy in older adults ' definitions of home.
The findings demonstrate the significance of ageing-related stereotypic beliefs and self-efficacy in guiding the health-promoting behaviours of older people.
The findings do not support a direct effect of cardiac function on CBF , but demonstrates gender-related differences in cardiac output distribution.
The findings draw attention to the limits of human agency under the constraints of early adversity-a process described as biographical structuration.
The findings emphasize that perceptions regarding one's future perspective may affect the quality of the relationship between and will-to-live.
The findings fall into three general categories.
The findings for E1 and calculated free T were similar.
The findings from dose-response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC.
The findings from @number@ high quality / low bias articles are summarized.
The findings from these studies provide a better understanding of what constitutes respect for older people , and a method for improving this in adolescents.
The findings from this analysis contradict several common assumptions.
The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.
The findings from this study did not support the association between job demands and decision latitude and CVD mortality.
The findings from this study support the use of arginine supplementation in PEG patients with PU.
The findings from two complementary studies are presented and discussed.
The findings have implications for the development of weight gain prevention programs for socially disadvantaged groups.
The findings have implications for understanding the mechanisms underpinning working memory deficits in both health and disease.
The findings have important clinical implications for the assessment and treatment of this patient population.
The findings highlight a likely contribution of NA to negative emotional memory , mediated via arousal that may be compromised with aging.
The findings highlight the complexity of dementia awareness and understanding.
The findings highlight the vulnerability of heavy smoking middle-aged and older women.
The findings illustrate the range of insights that can be gained into cognitive aging by incorporating neuropathologic indices into well designed , prospective cohort studies.
The findings imply that interventions that aim to improve elderly individuals ' SWB may promote their quality of life and , ultimately , EL.
The findings imply that shared cultural or religious normative values do not predict day-to-day care practices.
The findings indicate a dearth of information on the characteristics and care delivery of home care agencies and individual providers of nonmedical home care.
The findings indicate a need for improved dissemination of evidence-based health information and education for older drivers and their doctors.
The findings indicate a novel link between microRNA pre-processing and the timing of whole organism growth and development.
The findings indicated higher age declines and / or earlier onset of decline in swimming and running than cycling.
The findings indicated that cultural beliefs of SEA elders impact their ability to understand , recognize , and respond to depression.
The findings indicate harmony in living , enjoying being frank as well as rating the ' little ' things.
The findings indicate that EFAT2 might be an appropriate outcome measure to use within the palliative care setting.
The findings indicate that high sCysC levels were directly associated with decreased lung function in elderly Chinese men with COPD.
The findings indicate that informal church-based support is associated with healthy lifestyles among older African Americans but not older Whites.
The findings indicate that keeping the house warm in the winter can help to maintain physical performance.
The findings indicate that Lewy body disease impairs late life olfactory function even in otherwise asymptomatic individuals.
The findings indicate that recognition of accented speech , especially in noise , is a particularly challenging communication task for older people.
The findings indicate that social integration can mitigate as well as exacerbate depressive symptomatology among older Mexicans.
The findings indicate that specific isolated Premarin ( ® ) components differ in their ability to affect cognition and nAChR expression.
The findings in the elderly may partly depend on dysfunction in fronto-basal ganglia postural loops.
The findings invoke a new paradigm for community aging that highlights the unique contributions of older adults as a core social resource.
The findings may also be useful in other countries with growing aging populations.
The findings may be vital to the refinement of protocols for the efficient derivation of functional patient-specific HLCs for regenerative and toxicology studies.
The findings of both experiments were related to previous work suggesting that the bizarreness effect and the OD effect are mediated by different processing.
The findings of our review showed that BVs are under significant genetic influence at all ages , although different brain regions showed different heritability levels.
The findings of the current study have important implications for risk of disability and the need for , and use of , long-term care services.
The findings of the present study highlight the importance of ongoing genetic research into the cause of ALS and its likely future challenges.
The findings of the review will be disseminated in a related peer-reviewed journal and presented at conferences.
The findings of the simulations suggest that infants primarily utilize passive muscle stiffness to remain upright when they first begin to sit.
The findings of the study are that all four tasks activated PFC to some extent , without laterality except for the verbal fluency task.
The findings of this review may inform future , more rigorous research.
The findings of this study are used to develop an automated algorithm to verify the faces presented under disguise variations.
The findings of this study can help design proper instructional guidelines on healthy lifestyle in the elderly.
The findings of this study demonstrate that involvement in leisure activities offers substantial physical , psychological , and social benefits for older Korean women.
The findings of this study demonstrate that the semantic differential scale of sexual attitude is a reliable and valid instrument.
The findings of this study demonstrate the importance of a gender-based approach to the study of DV in older adults.
The findings of this study have implications related to gambling availability within an aging population.
The findings of this study imply that employment improves the quality of life and does not endanger health.
The findings of this study indicate that hippocampal atrophy in late life may be uniquely influenced by certain types of religious factors.
The findings of this study may be valuable in the development of intervention programmes aimed at sustainable , long-term reduction of falls in the elderly.
The findings of this study promote our understanding of the unique patterns of social connectedness in older immigrants.
The findings of this study will contribute to the development of vocal fold models that account for aging.
The findings point to gaps between facility philosophies of care and their translation into a care environment where care is truly resident-directed.
The findings point to important targets for future interventions.
The findings point to the importance of targeting health promotion and interventions through addressing negative age-attitudes.
The findings point to the interplay of personality and sociostructural conditions in the caregiving role over time.
The findings point to the need for attention to the mental health of elderly parents left behind in less economically developed regions.
The findings presented in this manuscript are a subanalysis of the EVIDENT study whose purpose was to analyze the relationship between lifestyle and arterial aging.
The findings provide an evidence-based molecular framework to understand the potential salutary effects of insomnia treatment on inflammation , with implications for inflammatory disease risk.
The findings provide no evidence that depressive symptoms have a detectable effect on changes in radiographic disease severity in knee OA.
The findings provide practical implications for the Health Administrative Department to allocate medical resources , and help hospitals to manage investments on medical facilities.
The findings provide preliminary but crucial clues for future studies specifically aimed at exploring the longitudinal relationships of interest before proceeding with interventions.
The findings provide valuable information for practical use for BM transplantation and contribute to the understanding of hematopoiesis from birth to adulthood.
The findings reaffirmed wet or dry chilling and aging as potential interventions for small plants as a critical control point.
The findings reflect the complex interaction between age , frailty , acute illness , and coagulation.
The findings remain largely unchanged in quartile and jackknife sensitivity analyses.
The findings revealed that older adults are more likely to comply with a mandatory evacuation order.
The findings reveal that in the majority of these documents there is no reference to the right to leisure.
The findings serve as an important empirical foundation for the evaluation and development of interventions designed to augment accelerated aging experienced by individuals with SCI.
The findings showed positive feedback and acceptance.
The findings showed that there was positive relationship between CHCE and bridge employment.
The findings show lasting improvement of skin quality and a youthful appearance.
The findings show that nursing homes increasingly receive deficiency citations for resident safety issues.
The findings suggest a link between AL and later life brain health and cognitive functioning.
The findings suggest a positive response to the presence of social work students in the enhancement of home healthcare and in this independent living environment.
The findings suggest a role of hippocampal atrophy in the decline in fluid intelligence in the elderly.
The findings suggest further nuances to the weathering hypothesis-social disadvantage can generate instability in physical function as minority adults age.
The findings suggest that addressing social issues faced by individuals in youthful age will go a long way to achieving good health in the future.
The findings suggest that both white matter volume loss and microstructural alterations should be considered more prominently in models of aging and neurodegenerative diseases.
The findings suggest that caregiving crises triggered intergenerational communication about caregiving alternatives and new arrangements , although each generation had different stances and motivations.
The findings suggest that driving status is likely to moderate the association between neighborhood environments and older adults ' leisure walking.
The findings suggest that health professionals working with individuals seeking guidance to modify their eating practices should assess a person's coping strategies to manage stress.
The findings suggest that high serum MIC-1 / GDF15 levels indicate reduced WM integrity and possibly greater WM pathology.
The findings suggest that HPA-axis dysregulation occurs at the MCI stage of AD and may accelerate disease progression and cognitive decline.
The findings suggest that , in combination , leader age and the age-related construct of generativity importantly influence leadership processes and outcomes.
The findings suggest that increased cognitive load during a gait and cognitive DT produces more pronounced gait measures of attention-prioritization in cognitively healthy older adults.
The findings suggest that longitudinal declines in fluid cognition are associated with reduced spoken language comprehension.
The findings suggest that more than half of rural elderly and @number@ percent of urban elderly were at some point abused.
The findings suggest that neuroaxonal loss and / or metabolic neuronal dysfunction , and decline in glutamate-glutamine neurotransmitter pool progress with aging.
The findings suggest that rostral ACC energy hypo-metabolism , possibly arising from neurodevelopmental processes , is associated with working memory impairment in schizophrenia.
The findings suggest that some prolonged seizure phases and prolonged PGES duration may be electroclinical markers of SUDEP risk and merit further study.
The findings suggest that SVDs in the brain and CAC in the heart may develop under similar systemic pathogenic processes.
The findings suggest that the intervention programme was of greater benefit for children than adolescents.
The findings suggest that the older AT practitioners walked with gait patterns more similar to those found in the literature for younger adults.
The findings suggest the need to develop race / ethnicity-specific strategies to screen psychiatric disorders in diverse elderly populations.
The findings support the cross-cultural use of a relatively inexpensive odor identification test as an early biomarker of cognitive decline and AD dementia.
The findings support the hypothesis that exposure to air pollution may affect vascular function.
The findings support the hypothesis that unirhinal olfactory assessment may assist in differentiating between demented and nondemented individuals.
The findings support the idea that the ecological validity of laboratory tasks influence age differences in emotion recognition.
The findings support the proposal that regular moderate-intensity walking improves aerobic fitness in adults with MCI.
The findings support the use of both human ASCs and BMSCs for clinical regenerative medicine.
The finding suggests the mutation does rarely contribute to the etiology of Parkinson's disease.
The findings underscored the need to support aging parents of adult children with ASD through enhancing their informal social support networks.
The findings underscore the importance of the association of caregiving transitions and caregiver health and the potential health benefits of ADS use for family caregivers.
The findings underscore the important role of telomere-regulating proteins for vascular cell function and survival.
The findings were compared with data obtained in the 1990s.
The findings were used to propose an Active Living Framework which is the subject of ongoing research.
The findings were validated in Cardiovascular Health Study and Health , Aging , and Body Composition study and were similar across various QT correction methods.
The findings will be of great significance to guide people to prevent dementia.
The findings would be valuable both in Japan as well as in other countries with rapidly growing aging populations.
The finding that resveratrol supplementation mimics caloric restriction prompted researchers to study the effects of resveratrol on lipid metabolism.
The finding that sociocultural differences shaped these cognitive representations underscores the need for cultural competency in patient assessment and education.
The finding that SPARE-AD in amyloid-negative MCI patients was predictive of clinical progression is not expected under the amyloid hypothesis and merits further investigation.
The finding that this pathway compensates for mitochondrial dysfunction to extend the replicative lifespan of yeast cells has generated additional impetus for its study.
The finding underlined the tremendous importance of preventing high blood pressure and its complication.
The finding was validated in a replication study ( OR = 0.66 , 95%CI @number@.48-0.90 , p = 0.011 for females ) .
The fine motor task was the Lifesaver task that required monkeys to remove a Lifesaver candy from rods of different complexity.
The Finnish version of IPA ( IPAFin ) was translated into Finnish using the protocol for linguistic validation for patient-reported outcomes instruments.
The first age-position was found to occur during the fifth decade and a later one during the eighth decade.
The first aim is to present evidence to support the use for combining exercise and cognition-focused interventions.
The first aim was to compute rates of transition from HC to MCI , and MCI to AD.
The first author wore an actimeter continuously for more than three decades , starting in @number@ at the age of @number@ years.
The first axis was associated with anemia , inflammation , and low levels of calcium and albumin.
The first biomarker to be studied was the MTL to discriminate age effects from those of radiation exposure.
The first BP reading was discarded , and the average of the remaining @number@ to @number@ BP readings was taken for analysis.
The first cases were observed in adolescents ( 15-19 years ) and a peak was observed in the seventh decade.
The first case was a 13-year-old girl who presented with nephritic syndrome and a rapidly progressive kidney failure.
The first cause of death is a malignant neoplasm , and opportunities of the treatment for elderly cancer patients are rapidly increasing.
The first cholesterol-limiting step and the final aromatase-limiting step are discussed as possible check-points of retinal functional / dysfunctional E2.
The first class showed higher memory functioning similar to younger adults , while the second class was characterised by lower memory functioning.
The first cohort ( n = @number@ ) was acquired at the Medical Prevention Center ( MPCH ) in Hamburg , Germany.
The first complete procedure consisted of a written assessment and personal counselling by physicians.
The first component , a primary injury , occurs at the time of impact and is the result of the mechanical insult itself.
The first component focuses on the precentral and postcentral gyri , and the caudate nucleus , which play an important role in sensorimotor tasks.
The first component includes lower frequency clonotypes for which distribution can be described by a power law.
The first concerned participants ' motivation for and assessment of the project.
The first consisted of a self-assessment questionnaire intended to perform an assessment on skin , hair , and nail health after @number@ days of treatment.
The first consistent and reproducible evaluation of the effect of aging on dynamic signature is reported.
The first dataset contained data from @number@ native Dutch elders aged 70-99 years.
The first data set ( \ "multi-task \ " ) consists of @number@ individuals engaging in four consecutive cognitive tasks.
The first Epo-producing cells emerge in the neural crest and neuroepithelium of mid-stage embryos and support primitive erythropoiesis in the yolk sac.
The first evaluation variable was the injection site pain measured using a 100-mm visual analogue scale ( VAS ) .
The first experimental indications have been already obtained indicating that both chronic and acute phenoptosis are suppressed by SkQ1.
The first feature group characterizes the waveform pattern of the EEG signal.
The first group of @number@ participants aged 60-75 years was recruited to measure their 1RM , 4-10RM , and 11-15RM of the three exercises.
The first group was observation only , while the second received gonadotropin releasing hormone agonists followed by cyclic oral contraceptives.
The first growth phase was before @number@ years and the second growth phase was between @number@ years and @number@ years of age.
The first harbored a NRAS point mutation ( c.35G > A ) in codon @number@ resulting in a p.G12D substitution.
The first included age , sex , and GCS.
The first includes a set of eleven measures that revolve around the absence of decline.
The first institute for hospice care was established in Tianjin.
The first is a phase II study in solid tumors , the second is a haematological trial on non Hodgkin lymphoma.
The first is a saccadic reaction time study assessing the efficiency with which multisensory integration varies as a function of aging.
The first is global change in the brain structure , observed more often in the earlier phase of development.
The first is : reserve is a hypothetical construct , and direct measures of reserve are not available.
The first is single agent chemotherapy , and the second is doublet chemotherapy.
The first is the average quality of diagnostic imaging procedures , defined as the fraction of procedures that are advanced procedures.
The first line of treatment of PHN is medication with tricyclic antidipressants and anticonvulsants.
The first-line treatment of hyperuricemia , which causes gout , is allopurinol.
The first local transmission in the continental United States was reported in Florida in @date@ .
The first metaphor captures the classical function of an axon as conductor of action potentials ( and information ) from one brain region to another.
The first method quantified the smoothness of the old and young dorsa.
The first @number@ min of sleep were excluded when a nocturnal SOREMP was recorded.
The first @number@ patients had a positive patch test reaction to Vita C Serum.
The first @number@ treatments were @number@ weeks apart.
The first objective is achieved by system suitability tests ( SST ) , which verify that mass spectrometric instrumentation performs as specified.
The first objective of this review and re-evaluation is to present a brief history of efforts to mathematically model the growth of tissues.
The first objective of this study was to examine a possible comorbid condition.
The first objective was to assess whether healthy individuals could accurately estimate their weight-bearing distribution in sit-to-stand transfers.
The first one included quality attributes.
The first one of calculated MNA-SF tests was with BMI , the second one with CC , and the last one with HGS.
The first part describes mastication adaptation in young healthy individuals.
The first part focuses on the evolution of the recording techniques and describes some methodological issues.
The first part of the report describes general characteristics of faculty trends , and the second part provides an analysis of those trends.
The first part of the study examined what the relatedness needs Korean elderly have in close relationships ( spouse , children , friends ) are.
The first patient was diagnosed with the typical radiological feature of long tapered stenosis due to mural hematoma.
The first-person view perspective taking is a potentially important candidate psychological marker for AD.
The first PIE iteration reveals an increase of 75-112% more peptides than the DDA method alone.
The first postulate requires that the cause of AD precedes the cognitive decline and neurodegenerative pathology that characterize AD.
The first principle component of change was strongly associated with age ( p < @number@ ) and heritable at @percent@ ( 27-62% ) .
The first quartile presented higher probability of survival compared to the last one.
The first reference to \ "imbecility \ " appeared in Greece in 6th century BC.
The first relates to the neuropathology of probable Alzheimer's disease , mild cognitive impairment , and those without dementia or mild cognitive impairment.
The first representations of knowledge in the AI's domain are largely based on model tests of semantic memory.
The first segment had two target sizes to alter accuracy constraints.
The first stage ( cognitive humor component ) involves the detection and resolution of incongruity , and is associated with activity in temporo-occipito-parietal brain areas.
The first stage in skills acquisition is to gather current views on dying and death.
The first step of pathological diagnosis starts to observe macroscopic findings of brains , which reveal the distribution of lesions specific to individual disorders.
The first step to accomplish this goal is to target them specifically , by unveiling and understanding their unique markers and signaling pathways.
The first study compares @number@ validated centenarians born in the United States between @number@ and @number@ to their shorter-lived siblings.
The first study on this was published in @number@ by Cuce et al. , as a treatment option for melasma.
The first study screened the psychometric properties of a battery of neuropsychological tests in order to identify those with optimal properties to evaluate cognitive aging.
The first suffered eye was taken as the observed eye when both eyes were involved.
The first supposes that senescence is programmed similarly to the genetic program of development from a zygote up to a mature organism.
The first theme of liminal life portrays the elders ' fears as they move through the stages of care.
The first theme , personal living environment , involves the subthemes privacy , autonomy and obtrusiveness.
The first trait covers clonality and sectoriality and the second concerns the lack of a differentiated germ line.
The first twenty pages of each search result were screened against @number@ variables.
The first two steps aimed to identify and select relevant articles.
The first used focus groups to assess IPP rewards , barriers , and facilitating factors among practitioners in clinical settings.
The first view ' Altogether now ' prioritises compassionate engagement.
The first visit included UHR performance ; the second visit included dynamic and static motion analysis.
The fist , the MIDAS Study demonstrated that DHA can be of benefit for episodic memory in healthy adults with a mild memory complaint.
The Fit and Strong ! education sessions focus on using PA to manage OA ; whereas Fit and Strong !
The fit between medical choices and the guideline or the reasons for non-implementation were recorded on clinical charts.
The fitting valley corresponds to the BMD fitting peak and may possibly be an effective means of determining the BTM reference intervals.
The five-category risk classification could be useful for therapeutic stratification or for diagnostic testing purposes once preventive treatment is available.
The five characteristics of frailty were operationalised using measures available in MUNS.
The five different corneal regions showed significant differences of corneal sensitivity ( p < @number@ ) .
The five dimension-specific measures together accounted for @percent@ of the variance in self-rated SA.
The five diseases with the worst QoL scores were scabies , pododermatitis , complicated atopic dermatitis , pemphigus foliaceus and endocrine alopecia.
The five groups were similar at baseline.
The five groups were similar at baseline.
The five key guidelines are : @number@
The five most common combinations of conditions associated with a certain disease concerned only a limited portion ( @percent@ ) of all disease comorbidity.
The fiveyear follow-up data showed no difference in the overall survival rate of employed and unemployed patients.
The FI was generated from @number@ deficits , including self-reported health , morbidities , functional performance and psychological assessments.
The FI was generated from @number@ self-reported health deficits.
The fixtures were separated at a velocity of @number@ mm / min in @number@ μm intervals to stretch the CCC to its rupture point.
The flanker task was used to assess EF.
The flap successfully sealed the oral cavity during the follow-up period.
The flexibility measurements were obtained by a fleximeter.
The flexible allocation of attention enables us to perceive and behave successfully despite irrelevant distractors.
The flexible goal adjustment ( FLEX ) and tenacious goal pursuit ( TEN ) scales are used regularly in aging research.
The flexor muscles around the hip joint include femoral rectus and abdominal muscles.
The flow area of ONH and the VD were automatically calculated.
The flow area of the ONH was @number@.74±0.10 mm / 1.34 mm.
The flow cytometry analysis of GLO-1 in leukocytes showed that expression index of GLO-1-positive cells was slightly increased in mononuclear leukocytes from diabetic patients.
The FLSQ comprises Baseline and Follow-up versions and was field-tested with @number@ subjects in a US observational study designed to assess its psychometric performance.
The fluidity of neuronal membranes plays a pivotal role in brain aging and neurodegeneration.
The fluorescence yield of the MET fraction from cataractous lenses also significantly increases.
The fluorescent properties of the GCIS / ZnS BQDs can be thoroughly optimized by varying reaction temperature , aging time , and ZnS coating.
The flux of essential metabolites , such as ATP , determines the functioning of the mitochondria to a noxious stimulus.
The FLZ questionnaire assesses the global life satisfaction of a person and health domain separately.
The FMR1 gene plays a role in defining FOR at all ages.
The fMRI analysis showed trends for increased activation during cognitive performance tasks immediately after and at @number@ weeks post-treatment.
The fMRI results revealed extensive age differences in the relationship between BOLD signal and MT , within and outside the sensorimotor system.
The fMRI results suggest that training entails activity in sensory as well as higher motor centers and brain areas known to be involved in navigation.
The fMRI showed only minimal activation in response to the @number@ kHz stimulation , despite the fact that all subjects heard the stimulus.
The FN400 results additionally suggest that task switching may have a detrimental effect on familiarity-based memory retrieval.
The FN upregulation of PKG-I protein content was due to increased mRNA expression , determined by augmented transcriptional activity of the PKG-I promoter region.
The focal length and chromatic and spherical aberrations are observed to change owing to age-related refractive index variation in the lens.
The focal point of all skeletal pathologies is the deregulation of bone remodeling , mediated by bone-forming osteoblasts and bone-resorbing osteoclasts.
The focus group meetings lasted approximately @number@ minutes , were digitally audio-recorded , and transcribed verbatim.
The focus is now shifting from physical well-being to improvement in mental well-being or maintenance of cognitive function in old age.
The focus is on enhancing the competent use of coping skills via BA.
The focus of research in the HIV field has recently switched towards elimination of the HIV reservoir as a means of combating long-term HIV complications.
The focus of the current analysis was on the effects of the NYUCI-AC on change in primary subjective stress over @number@ @number@ and @number@ months.
The focus of the current review is the examination of evidence from rodent models investigating the critical period hypothesis.
The focus of the discussions ranged from current research progress , challenges and opportunities , to future directions on these topics.
The focus of this paper is on the types of dietary protein that people might reasonably consume to offset sarcopenic muscle loss.
The focus of this report was graduate nursing students ' reflections on elder and end-of-life care for prisoners.
The focus of this review is on the impact of aerobic activity on the progression and symptom control of OA.
The focus of this review was on the relationship between obesity and brain alterations assessed by DTI.
The focus of this study resides within a novel approach to target survivin , an integrator of both cell death and mitosis.
The focus of this study was on the association between sarcopenia and pre-sarcopenia in kidney transplant recipients.
The focus was on expression in Escherichia coli , as this allows incorporation of isotope-labeled amino acids , and on finding conditions that enhance solubility.
The focus was on the impact of specific comorbidities and radiologic data.
The fold lies above one subcutaneous fat compartment that can be used for augmentation.
The following chapter presents preliminary explorative results of a survey delivered on @number@ elder individuals ( 65-80 yrs. ) leaving in Milan.
The following conditions were evaluated : dyslipidemia , systemic arterial hypertension , and type @number@ diabetes.
The following databases were accessed on @date@ : Medline , Cochrane Collaboration , Ovid and Scholar Google.
The following day , patients applied a chemical sunscreen and went into either shaded or direct sunlight for 15-30 extra minutes depending on sensitivity.
The following factors were associated with a greater rate of local control : maximum dose and mean dose.
The following FS indicators were assessed : weight loss , exhaustion , weakness , slowness , and low physical activity level.
The following indicators were also evaluated : social contacts , and performing mental , physical and leisure activities during late-life.
The following information was extracted from the selected studies : device type , number and type of patients , intervention , and main outcomes.
The following is a detailed and evidence-based article , on how hospital medicine might benefit both the public and prívate healthcare systems in Chile.
The following key word combinations were used , limited to the title : elderly or older people or older adults and fall and risk.
The following motor measures were obtained : grip force , tapping speed , bimanual visuomotor coordination , and manual dexterity.
The following nutritional biochemical parameters were also evaluated : albumin , cholesterol , iron , and hemoglobin.
The following parameters are proposed to estimate in survival curves analysis : Median Life Span , Hill slope , Expected Maximal Life Span.
The following review focuses on the roles that autophagy plays in response to the ROS generated in several diseases.
The following review is intended to provide the practitioner with practical knowledge for safer and more effective treatment of pain.
The following review summarizes the relationship between heart failure and frailty , and the utility of a frailty assessment in heart failure management.
The following stains were used : Modified Goldner's Masson trichrome , Ferric Orcein-Hematoxylin and the combined stains Orcein-Goldner's trichrome.
The following update gives recent research results on the withdrawal pathophysiology and practical information in order to treat or prevent benzodiazepine withdrawal syndrome.
The following variables were considered : type of enamel surfaces , prismatic vs aprismatic enamel , etching time , and aging and shearing procedures.
The follow-up includes an yearly self-administered questionnaire , a periodic visit to an HSC and linkage to social and national health administrative databases.
The follow-up period ranged from @number@ months to @number@ years.
The follow-up period ranged from @number@ to @number@ months with mean @number@ months.
The follow-up period was @number@ months , to @date@ .
The follow-up period was @number@ year.
The follow-up period was the time between liver biopsy and TE.
The follow-up re-evaluation in surviving patients showed a recovery of values to the range expected for Parkinsonisms of same disease duration.
The follow-up test scores from a total of @number@ employees were significantly higher in the submaximal aerobic capacity test ( p < @number@ ) .
The follow-up time ranged from @number@ to @number@ months.
The follow-up time was @number@.26-19.3 years.
The follow-up time was @number@.7±1.9 ( 12-19 ) months.
The follow-up time was taken into account in the analyses.
The follow up was @number@ months.
The follow up will be specified as well as the management of the possible complications.
The Food and Drug Administration ( FDA ) has been more proactive in regulating sunscreen products.
The Food Craving Inventory ( FCI ) was used to measure cravings at baseline and at @number@ and @number@ months.
The food industry is the point of final integration of consumer food choices with dietary guidelines.
The food preparation was detected with a sensitivity of @percent@ and a specificity of @percent@ using a vision sensor.
The foot movement times were significantly increased with both immobilization devices compared with the running shoe ( p < @number@ ) .
The foot's trajectory resembles pendulum motion but further work will be necessary to test the foot-pendulum control hypothesis.
The force and range-of-motion angle required for a passive exercise apparatus is also examined with the help of a professional physical therapist.
The forced expiratory vital capacity , FVC , was calculated by FVC = @number@.0615 H - @number@.0308 A - @number@ r = @number@
The force-generating capacity of the type I and IIa MyHC isoforms was , on the other hand , not affected by old age.
The force variability of tapping at @number@ Hz further increased with age , indicating an effect of aging on the control of force.
The forgetting rates in children decreased with age , and the forgetting rates for monkeys were most comparable to those of younger children.
The Forkhead box O ( FOXO ) transcription factors are regulators of life span and tumor suppression.
The formalism produces large-scale , quasi-equilibrium ' resilience ' states representing normal and pathological protein folding.
The formant transitions ( F2 slopes ) of the diphthongs in the target words were compared across lexical categories between PD and HC groups.
The format and content of intergenerational communication indicated that both conflicts and compromises took place.
The formation and accumulation of AGE have been known to progress at a normal physiological aging and at an accelerated rate under diabetes.
The formation of advanced glycation endproducts ( AGEs ) occurs in diverse settings such as diabetes , aging , renal failure , inflammation and hypoxia.
The formation of AGEs results in the generation of free radicals which play an important role in the pathophysiology of aging and diabetic complications.
The formation of an oxide layer may inhibit the outward movement of ions , thereby acting as an obstacle for release.
The formation of cross-links between collagen fibers is regulated by the action of lysine hydroxylases and lysyl oxidase and could occur spontaneously.
The formation of large aggregates containing CHIP is a consequence of its binding to misfolded proteins and to molecular chaperones.
The formation of lipofuscin is related to oxidative enzymatic activity and free radical-induced lipid peroxidation.
The formation of L- isoaspartyl residues in proteins alters their three-dimensional structure leading usually to a loss of function.
The formation of new cardiomyocytes in response to exercise suggests that exercise might be a useful tool to enhance cardiac regenerative capacity.
The formation of new tissue may replace damaged or dysfunctional tissue to preserve cellular integrity and function after injury.
The formation of reactive oxygen species and the induction of matrix metalloproteinases reflect the central aspects of skin ageing.
The formation of reactive oxygen species ( ROS ) is a widely accepted pivotal mechanism leading to skin aging.
The formation of the hippocampus is generated during embryonic development , but most neurons within the structure are produced after birth.
The formation of these polymers ( aggregates ) leads to an unregulated and , consequently , pathological protein network.
The former are believed to be the major intracellular compartments where the APP is cleaved by BACE1 and β-amyloid is produced.
The former attempted a crossword daily for @number@ weeks while the latter kept a daily gratitude diary for the same period.
The former group had advanced age with a greater burden of cognitive impairment , gait disability , arrhythmia , and fall risk medications.
The former group underwent a three-month program of two 60-minute sessions each week , with the socially active volunteers paired up with them during practice.
The former is based on the exponential increase in the incidence of AD with ageing , while the latter on AD prevalence rates.
The former is more likely to progress to dementia than the latter.
The former primarily shortened reaction times while the latter primarily improved memory accuracy.
The form of the glands in the different parts of human urinary bladder ( proximal , middle and distal ) is difference.
The forms were completed by the main caregivers of @number@ adults with a genetically confirmed diagnosis of PWS.
The formulation increased the hydration and protected the skin barrier function after a single application.
The formulation of the retinyl retinoate , however , is required to enhance skin permeation , and thus to increase the anti-wrinkle effect.
The formulations showed accepted gelation temperature ranging from @number@ to @number@ °C and all had pH value of @number@
The formulations used must be kept under refrigeration and should be manipulated every @number@ days.
The formulations were evaluated regarding gelation temperature , pH , viscosity , syringeability study , in-vitro release and chemical stability of cur.
The formulations were subjected to polarized light microscopy , which indicated the presence of a hexagonal mesophase.
The fornix and hippocampus are critical to recollection in the healthy human brain.
The forward swing phase of the trailing leg was rapidly interrupted and reversed in direction.
The fountain of youth has always been a myth for mankind.
The four articles adopt cross-sectional and longitudinal methodologies and offer key insights into the nature , correlates , and developmental trajectories of subjective memory.
The four cohorts varied considerably in age , education , ethnicity / race , and APOE-e4 allele frequency.
The four-disc version is a promising method of assessing planning in children and adolescents in clinical situations.
The four-factor model provided good approximate fit ( comparative fit index , @number@ standardized root-mean-square residual , @number@ ) .
The four-factor SAI-K showed reliable internal consistency with a Cronbach's alpha for the total scale of @number@
The four-item Cohen's Perceived Stress Scale ( PSS ) was also administered at baseline.
The fourth generation mice with telomerase deletion have progressive shortening of telomeres.
The fourth group was the irradiated negative control group ( no therapy ) .
The fourth Leon Thal Symposium ( LTS2010 ) was convened in Toulouse , France , on @date@ .
The fourth one identified participants ' attitudes toward assistive ICTs , designed specifically for older adults ( \ "gerontechnologies \ " ) .
The fourth question addressed relative two-wave longitudinal changes.
The fourth recall trial was administered @number@ week later.
The fourth study documented an interaction for the CFH genotype only.
The FoxO family of forkhead transcription factors is at the crossroads of many signal transduction pathways that are evolutionarily conserved.
The FOXO forkhead transcription factors are involved in metabolism control , cell survival , cellular proliferation , DNA damage repair response , and stress resistance.
The FOXO genes are homologues of daf-16 , a key regulator of the insulin-IGF1 signaling pathway and a modulator of lifespan in Caenorhabditis elegans.
The FoxO signaling is regulated by their interactions with other intracellular proteins as well as their post-translational modifications such as phosphorylation.
The fractal dimension is a global measure of complexity and is useful for quantifying anatomical structures , including the retinal vascular network.
The fractal dimension was measured based on the log log plot of the number of grids versus the size.
The fractional @number@ nm laser was comprised of a thulium rod pumped by a pulsed alexandrite laser.
The fraction of IMCL touching mitochondria was lowest in old women in the total area and in old men in the subsarcolemmal region.
The fraction of population disability attributable to obesity followed a similar trend.
The fractured surfaces of all specimens were examined under scanning electron microscopy ( SEM ) to evaluate the failure mode on the enamel surface.
The fracture risk assessment tool may be used in osteoporosis consultation in many countries.
The fracture risk of men and women were calculated separately.
The fragile X mental retardation @number@ ( FMR1 ) gene is primarily associated with neuro / psychiatric risks.
The fragments of the wall of the ascending aorta were fixed in @percent@ formalin solution immediately following its resection.
The frail group showed no reduction in entropy values in either direction , and the pre-frail group showed no reduction in the ML direction.
The frail phenotype is considered present if three or more of the indicators are observed.
The frailty index and the modified frailty phenotype each confirmed previously established characteristics of frailty scales.
The frailty index describes frailty as a nonspecific age-associated vulnerability , reflected in an accumulation of medical , social , and functional deficits.
The frailty index score was significantly lower among subjects with higher calf circumference ( @number@ versus @number@ p = @number@ ) .
The frailty phenotype is grounded in a theoretical construct hypothesized to have an underlying biological basis.
The frailty phenotype was modified from a previously adapted version and a 46-item frailty index was created following a standard protocol.
The frailty , prefrailty , and nonfrailty states were defined according to the Fried and colleagues ' criteria.
The frailty syndrome is a pre-disability condition suitable to be targeted by preventive interventions against disability.
The frailty syndrome is considered one of the most important limitations when treating octogenarians with type @number@ diabetes in polypharmacy.
The frame ratio was defined by anthropometric measurements of modern portraits of twenty consecutive Miss World winners.
The framework and proposed implementation could be used to conceptualize and implement evidence-informed policymaking.
The Framework includes methodological considerations and environmental and personal contextual factors ( or lenses ) through which to approach research in the field.
The framework incorporates a physically informed generative model of smooth B1 ( + ) inhomogeneities and their multiplicative effect on R1 estimates.
The framework of social epidemiology provides infectious disease researchers with such a perspective and research opportunity.
The FRASER program enrolls only patients aged ≥70 years.
The free active fraction is affected by age because of the reduced α ( @number@ ) -acid glycoprotein plasma concentrations in neonates.
The free and right ear-directed recall DDTs were administered using @number@ sets of triple-digit pairs with a @number@ dB HL presentation level.
The free androgen index ( FAI ) and TG / HDL-chol were calculated.
The free radical theory of aging indicates that redox imbalance may be an important factor in the aging process.
The free radical theory of aging posits that aging is caused by accumulation of damage inflicted by reactive oxygen species ( ROS ) .
The free radical theory of aging postulates that the production of mitochondrial reactive oxygen species is the major determinant of aging and lifespan.
The free-radical theory of aging was proposed more than @number@ years ago.
The frequencies of APOE-​ε2 , ε3 and ε4 were @number@ @number@ and @percent@ , respectively.
The frequencies of rare sequence variants in NPC1 / 2 did not differ significantly between patients and controls.
The frequencies of structural abnormalities , according to both Abadie's sign and the Toronto Clinical Neuropathy Score , were determined.
The frequencies of visits and hospitalizations and costs from primary sectors were based on data from the National Health Security.
The frequency and accuracy of reoccupation of the synaptic sites by TSCs and axon terminals are impaired.
The frequency and duration of VA were measured through computer-assisted direct observation several times before , during and after the intervention.
The frequency and severity of periodontal diseases is known to increase in elderly subjects.
The frequency and severity of treatment-emergent adverse events ( TEAEs ) were also documented.
The frequency deviations impaired performance more in physically inactive than active seniors.
The frequency of abnormal tests in all diagnostic groups increased with functional impairment as assessed by the Clinical Dementia Rating scale ( CDR ) .
The frequency of activated CSF CD8 T cells positively correlated to CSF HIV RNA and to markers of CNS inflammation.
The frequency of adverse effects of anti-TNFs is higher in an elderly population , although the same is seen with comparator disease-modifying treatments.
The frequency of alcohol intake in the previous three months was obtained through self-reports of interviewees.
The frequency of butter consumption decreased ( p < @number@ ) and consumption of vegetable fats increased ( p < @number@ ) .
The frequency of CD11b ( + + ) neutrophils correlated with plasma TNF , and recombinant TNF elevated neutrophil CD11b ex vivo and in vivo.
The frequency of CD28 and CD95 demonstrated a \ "curved \ " rather than linear tendency by age.
The frequency of consumption of meat and fats seemed to be among the determinants of SRC and hemoglobin values.
The frequency of control attempts and patients ' behavioral responses , however , were unrelated to patients ' depressive symptoms.
The frequency of diabetes mellitus and hyperlipidemia peaked in patients in their 50s or 60s and gradually decreased thereafter.
The frequency of extracolonic Lynch syndrome-associated cancer was significantly lower with suspected familial colorectal cancer type X than with Lynch syndrome.
The frequency of GCH1 variants was evaluated in whole-exome sequencing data of @number@ cases with Parkinson's disease and @number@ control subjects.
The frequency of hyoid bones with diarthrodial structure of this joint was compared between the age groups.
The frequency of hypertension increased with age , peaking in patients in their 70s , and decreasing slightly thereafter.
The frequency of idiopathic peptic ulcers seems to be rising and their prognosis is worse.
The frequency of left jugular venous reflux ( JVR ) also increased with aging.
The frequency of MATR3 mutations in ALS patients in Taiwan is , therefore , approximately @percent@ ( @number@ of @number@ ) .
The frequency of MN in lymphocytes was significantly higher in the exposed group ( P < @number@ ) .
The frequency of nonvalvular atrial fibrillation is increasing in sub-Saharan Africa , particularly as a consequence of population aging and the high prevalence of hypertension.
The frequency of osteoporosis was found to be @percent@ and osteopenia was @percent@ in control subjects.
The frequency of outliers from undetermined methodological causes was highest for blood , but less than @percent@ for all values.
The frequency of participation across @number@ types of community-based activities was assessed.
The frequency of plasma and memory B cells from both sources decreased with age , while immature and naïve B cells were unaffected.
The frequency of side-effects was also assessed.
The frequency of spontaneous contraction and the MDA decreased significantly ( P < @number@ @date@ ) .
The frequency of the G allele was @number@ and @number@ in white and black , respectively.
The frequency of these HSC populations in trochanteric and femoral bone marrow rose significantly with age.
The frequency of trips outdoors is a strong indicator of older adults ' physical activity levels.
The frequency ranges of the monaural spectral notch cues to source elevation are also expected to decrease.
The frequency was significantly higher in autosomal dominant PD ( ADPD ) compared with autosomal recessive PD.
The frequent claims of health benefits , smoking cessation , strategies appealing to youth and women are concerning , especially targeting women.
The frequent co-occurrence of hypothyroidism with other multiple chronic conditions characterizes it more as a comorbidity rather than an isolated chronic disease.
The frequent occurrence of an S-acetyl intermediate before lysine N-acetylation suggests that proximity to a thioester is a key determinant of lysine susceptibility to acetylation.
The frequent use of diuretics in old people may be accompanied with dehydration and risk of developing thromb formation.
The FRET-based seeding assay may also complement standard neuropathological classification of tauopathies.
The FRET phenomenon was also predicted by acceptor photobleaching using confocal microscopy.
The Fried index was measured as the gold standard.
The Fried model revealed the strongest associations with the frailty outcomes ( dependence and performance ) .
The friend-centered / restricted ( @percent@ ) and diverse / no children network types ( @percent@ ) were the most prevalent.
The frontal and the occipital portions of the skull caps of adult females and males were investigated separately.
The frontal-executive domain was significantly associated with poor cognitive performance in the low eGFR group ( p < .001 ) .
The frontal-parietal executive system plays an important role in cognitive aging and is also vulnerable to damage in elderly patients with hypertension.
The fronto-limbic network interaction , driven by glutamatergic and dopaminergic neurotransmission , represents a core mechanism of motivated behavior and personality traits.
The fruit fly Drosophila melanogaster has emerged as a useful model for cardiac diseases , both developmental abnormalities and adult functional impairment.
The fruits and fruit extracts have potential in inhibiting the growth of cancer cells and reducing DNA damage induced by chemicals and radiation.
The fruits are rich in a wide range of bioactive phenolics.
The fruits of this progress are largely applicable to adults with congenital heart disease.
The fruits of various Zanthoxylum species are used as a spice in the Chinese and Japanese cuisine because of their delicate flavour and tingling properties.
The FSES was evaluated in two studies of older Israelis , aged 75 + years.
The FTLD group had a significantly higher prevalence of HS / MTS than that of the AD group.
The FTO rs9939609 polymorphism was genotyped using DNA samples collected at baseline and LTL was assessed at the 10-year follow-up period.
The FTP-PET measures were computed as standardized uptake value ratios.
The FTs of the mid-cheek exhibited almost no change among the age groups ( all P > 0.05 ) .
The FTSST and cognition shared almost the same common environmental factors but only part of the unique environmental factors , both with negative correlation.
The FTT sequence was performed faster at retest than at the end of the learning session , indicating an offline boost in performance.
The full analysis set will follow an intention-to-treat principle and will include all randomised participants for whom a baseline assessment is conducted.
The full coding region of sheep FVIII mRNA was sequenced to identify the genetic lesion.
The full complement of molecular pathways contributing to the pathogenesis of Parkinson disease ( PD ) remains unknown.
The full protocol is available from PROSPERO ( PROSPERO 2014 : CRD42015010616 ) .
The full protocol is available from PROSPERO ( PROSPERO2014 : CRD42015010616 ) .
The full protocol is available from PROSPERO ( Record ID : CRD42015010616 ) .
The full spectrum of activities of the tumor suppressor p53 ( TP53 ) has not been completely elucidated yet.
The full spectrum of Aβ peptides was determined by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.
The full strain tensor of the outer scleral surface was calculated directly from the displacement field.
The full-thickness bladder tissues were obtained at least @number@ cm away from the margin of the tumours.
The full-year consolidated data files from @number@ to @number@ were pooled to yield a final analytic sample ( N = @number@ @number@ ) .
The \ "functional autonomy measurement system \ " ( SMAF ) was used to evaluate functional autonomy.
The functional connectivity decrease was not due to structural changes but to a decrease in response amplitude.
The functional consequences of the interactions between FoxO1 and SIRT1 remain incompletely understood.
The functional consequences of the mutations were analyzed using PolyPhen.
The functional consequences of the mutations were analyzed using PolyPhen2.
The functional development was assessed with a speech discrimination task based on the dichotic presentation of consonant-vowel syllables.
The functional difference caused by rs2229116 needs to be investigated.
The functional form to model the association between Aβ and regional brain atrophy has not been well defined.
The functional impact of carbonylation was assessed in human vein endothelial cells by studying models of modified human serum albumin.
The Functional Independence Measure ( FIM ) and Barthel Index were determined as indices of physical function.
The Functional Independence Measure ( FIM ) is used by rehabilitation professionals to access disability.
The functionality ex vivo was strongly associated with soluble inflammatory markers.
The functional-linkage network should be a valuable resource for the study of biological functions of mitochondrial proteins and human mitochondrial diseases.
The functionally impaired group had lower anti-CD3 responses , but gradually increased responses against CMV.
The functional muscle-bone unit was calculated as the ratio between the bone mass to muscle mass.
The functional relationship between parathyroid glands and prostatic gland is commonly very well known.
The functional relevance of this observation deserves to be investigated in vivo.
The functional response of RA and their receptors are modulated by a host of coactivators and corepressors.
The functional role of endogenous EWS at stem cell level on both senescence and tumorigenesis is a link between cancer and aging.
The functional role of Sir-related enzymes @number@ ( sirtuin @number@ ) in treating liver cancer still requires further investigation.
The functional role of T-bet + B cells is unclear , although it is known that T-bet promotes class switching to IgG2a / c.
The functional significance of genes that showed differential expression between young and old tendon was determined by using ingenuity pathway analysis.
The functional significance of this binding is unknown.
The functional significance of this residue has not been investigated previously.
The functional state was assessed by Barthel Index ( BI ) and Activity Daily Living ( ADL ) .
The functional time of such devices is a crucial aspect.
The functional vitamin B12 deficiency and the associated hyperhomocysteinemia are risk factors for neurodegenerative diseases and accelerate bone loss.
The function and mass of the neuromuscular system gradually deteriorate during the natural process of aging.
The function and volume of thyroid were also measured.
The function of AGK as a subunit of the TIM22 complex does not depend on its kinase activity.
The function of each organ including the brain tends to decline with aging.
The function of neuronal collagen XVII remains unclear.
The function of p21 in mitosis has been proposed but not systematically studied.
The function of the aging heart is mostly compensated by the hypertrophy of the remaining myocytes.
The function of the eye and ear represents a unique window for testing various conditions in cognitive decline or dementia.
thefunction of theknee joint muscles.
The function of these genes and their contribution to PD pathogenesis remain to be fully elucidated.
The function of this all-glass culturing device was confirmed by culturing HeLa , fibroblast and ES cells.
The function of VASH1 may not be restricted to angiogenesis inhibition.
The functions of autophagy overlap remarkably with those of vitamin D / VDR signaling.
The functions of both DCs and AECs are impacted with age.
The functions of the bladder and terminal bowel are regulated by complex neuronal networks.
The functions of TSPs in myocardium , vasculature , vascular complications of diabetes , aging and immunity are discussed.
The fundamental differences in these four methods are the roles of CA and the selection criteria of aging biomarkers.
The further study revealed that the voltage-dependent inactivation of sodium currents were more slow in adult atrial cardiomyocytes than pediatric atrial cells.
The fusion protein TAT-Cygb , whose expression was induced by lactose , was purified by CM Sepharose Fast Flow Protocol and verified by Western blotting.
The fusion rate was @percent@.
The fusion rate was @percent@ at final follow-up.
The FUS protein is physiologically mainly located in the nucleus , while cytoplasmic FUS aggregates are pathological hallmarks of FUS-ALS.
The FUS / TLS-NKAP interaction takes place through the RS domain of NKAP and the RGG1 and RGG3 domains of FUS / TLS.
The future formulations and applications of BoNT type A will be plentiful , and are exciting to consider.
The future , however , may be brighter , with multiple new agents recently available.
The future of genetic diagnostics will see a move toward massively parallel next-generation sequencing of a patient's DNA.
The future of this therapeutic modality continues to be exciting.
The future potential of these methods include further discoveries in functional genomics and contributions to the elucidation of the histone code.
The future remains bright for fractionated laser devices and with new devices and wavelengths , the applications of this technology continue to grow.
The fuzzy-logical model of perception confirmed the significant impact of aging on audio-visual integration by showing an increased weight of audition in the older group.
The gain is consistent with a selectively relaxed regime , until purifying selection slows it down as aging genes accumulate a large number of variants.
The gains of the mechanisms are adapted so that their mean response under one context is equated for a different context.
The gait indices obtained by autocorrelation of trunk acceleration can be considered useful to evaluate aging effect on gait.
The gait protocol contained @number@ unexpected soft trials to quantify the reactive adaptation.
The gait speed and handgrip strength cut-off points were defined as the 20th percentile of their population distributions.
The gait speed , grip strength and maximal isometric knee extension strength were measured.
The Gait Variability Index ( GVI ) , a composite measure of variability across several gait parameters , was previously developed to overcome this challenge.
The Gal-3-HF relation was seen for HF with and without antecedent coronary heart disease.
The gallbladder bed did not contain cytokeratin 19-positive cells.
The G-allele was more prevalent among patients with MDD.
The games Conveyer Belt , Sunshine , and Papyrinth have AFR ICCs of @number@ @number@ and @number@ respectively.
The game was designed and developed by a multidisciplinary team.
The gap in cardiometabolic burden between men and women has also persisted.
The Gaps-In-Noise ( GIN ) test ( Musiek et al , @number@ ) was used to assess temporal resolution ability.
The gap space between the head of the implant and the inner surface of the attachments was detected.
The gastric concentrations of cytokines representative of the innate and Th1 response were higher in the H. pylori-positive than in the -negative children and adults.
The gastrointestinal ( GI ) system is responsible for the digestion and absorption of ingested food and liquids.
The gastrointestinal microbiota produces short-chain fatty acids , especially butyrate , which affect colonic health , immune function and epigenetic regulation.
The GAT correction equation can consider the combined effect of PCT , Pa , CCT , and age on IOPG.
The gathered data were analyzed by the Mann-Whitney U-test , the Kruskal-Wallis test , Spearman's rank correlation coefficient , and the receiver-operating characteristic.
The GBD @number@ study results demonstrate that progress is possible in the war against cancer.
The GCIS / ZnS@PLVs present great potential as bimodal imaging contrast agents for tumor diagnosis.
The GCS was lower as TBV decreased , AWM increased , and WM-FA ( all p < 0.01 ) .
The GDS-15 optimal cut-off was @date@ with a sensitivity of @percent@ , specificity of @percent@ , PPV of @percent@ and NPV of @percent@.
The GDS score was an independent significant inverse determinant of 24-h SD of SBP.
The GDTs of the other groups fell between those of the younger adults and youngest children.
The GDxVCC analyses were adjusted further for typical scan score to handle atypical retardation.
The gel structure formation was confirmed by viscoelastic measurements.
The gender difference in the disability group and the role of culture on these differences need further research.
The gender differences in bone-muscle relationship may be helpful for the development of gender-specific preventive strategies in the elderly , especially in men.
The gender distribution differed with age.
The gender of the child did not matter for the association between parenthood and mortality.
The gender repartition revealed a higher frequency in the case of female patients ( @percent@ ) .
The gene dosage-dependent function of SIRT1 in DNA repair and cell survival is consistent with the dual roles of SIRT1 in UVB-induced skin tumorigenesis.
The gene expression analysis was limited to @number@ individuals with both imaging and brain RNA sequencing data.
The gene expression patterns from the subset of women who were younger-appearing were similar to those in women who were actually younger.
The gene expression profile of the study subjects was determined with HumanHT- @date@ Expression BeadChip from peripheral blood mononuclear cells.
The gene expression related to chondrogenesis and proteoglycan synthesis was significantly higher in the LSCS group.
The gene lists were compared and analyzed as well with Ingenuity Pathway Analysis.
The gene products of these delayed response genes are ultimately responsible for the changes in the biochemistry and physiology of resveratrol-treated cells.
The general advised target blood pressure is < 140 / 90 mmHg for patients with cardiovascular disease or chronic kidney disease.
The general age-related conformities in forming CIP and FMNP were established favoring the genetically determined program for development of these nervous system properties.
The general aims of rehabilitation are to increase functioning and improve patients ' activities , participation level , and quality of life.
The general caspase inhibitor , z-VAD-fmk , completely abolished cordycepin-induced cell death , demonstrating that cordycepin-induced apoptosis was dependent on the activation of caspases.
The general characteristics , laboratory test results and GNRI of the patients at baseline were recorded.
The general confirmatory factor analysis model had a good fit.
The general deficit in fulfilling the needs of the patients was low.
The general diagnosis of MCI was based on criteria.
The General Health Questionnaire ( GHQ-12 ) score of @number@ or more was defined as poor mental health.
The general information , postoperative pathology results , surgical options and followup were also collected.
The generalizability of the models was estimated using leave-one-out cross-validation.
The general limitations of QOL assessment in the elderly population are discussed in the review.
The generally accepted mechanism of metformin's effect is stimulation of adenosine monophosphate ( AMP ) -activated protein kinase ( AMPK ) .
The general pattern of results suggests that hearing loss , age , and cognitive factors limit the ability to recognize Spanish-accented speech.
The general population average could be influenced by age with its accompanying physiological changes and / or illness.
The general prevalence of urinary incontinence was @percent@ , higher among the women.
The general reliability of EQ-5D for cases was @number@ and for controls @number@ for each dimension.
The general screening ability of the Braztel-MMSE was high ( AUC = @number@ CI95% = @number@.964-1.001 ) .
The general severity of symptoms was assessed by a clinician using the Clinical Global Impressions Scale for Severity ( CGI-S ) .
The general theoretical framework for this research is the Transtheoretical Model ( TTM ) of Health Behavior Change.
The general trend in MNA-SF scoring was more consistent with these patterns as a group ; but requires clarification in larger cohorts.
The general trends were similar for @number@ m middle-distance running and @number@ m freestyle swimming.
The generation of functionally specialized neural subtypes from hPSCs relies on fundamental developmental principles learned from animal studies.
The generation of gametes falls between two reprogramming phases.
The generation of reactive oxygen species ( ROS ) is a fundamental aspect of normal human biology.
The genesis of brain AVM remains enigmatic.
The genes related to CpGs in ME3 are enriched for polycomb group target genes known to be involved in cell renewal and aging.
The genetic aetiology was remarkably stable.
The genetically encoded indicators , based on fluorescent proteins , have provided new opportunities in biomedical research.
The genetic and environmental impacts on correlations between hearing and cognitive functions have not been well studied.
The genetic architecture described here will be useful in the analysis of myriad biological and clinical traits within this study.
The genetic architecture of amyotrophic lateral sclerosis ( ALS ) is being increasingly understood.
The genetic background , thus , takes center stage as a driver of epigenetic dysregulation in AML.
The genetic basis controlling language development remains elusive.
The genetic basis of disorders of lens development , including paediatric cataract ( lens opacity ) , are also discussed in this section.
The genetic contribution is suggested to be more potent in EOAD.
The genetic contribution to the variation in skin aging in non-Caucasian populations is poorly understood.
The genetic correlation among the PS measures was strongest for DS and TMTA , and between the PS measures and GCA was strongest for DS.
The genetic correlations across the @number@ occasions ranged from @number@ to @number@ and did not differ significantly from @number@
The genetic covariance between ME and depression accounted for @percent@ of the phenotypic correlation.
The genetic determinants of body fat distribution are poorly understood.
The genetic findings warrant further studies to identify and characterize SOX5 variants that confer risk for AD , ALS and intellectual disability.
The genetic , genomic and epigenetic influences on human longevity are expected to be much more complex.
The genetic influence on the bone qualities assessed by QUS remains an under-studied area.
The genetic influences on aging-related phenotypes , including cognition and depression , have been well confirmed in the Western populations.
The genetic landscape of classical myeloproliferative neoplasm ( MPN ) is in large part elucidated.
The genetic material of all organisms is susceptible to modification.
The genetic , pharmacological , physiological , and pathological aspects related to ADAMTS13 / VWF have been extensively investigated.
The genetics of aging is typically concerned with lifespan determination that is associated with alterations in expression levels or mutations of particular genes.
The genetics of NER mutations have provided important insights into the distinct consequences of genome instability.
The genetic variation between each individual may be responsible for interindividual differences.
The gene tyrosine hydroxylase @number@ ( TH01 ) has been suggested as a candidate for human longevity.
The genomes of a wide range of different organisms are non-randomly organized within interphase nuclei.
The genomic analyses revealed that most differentially methylated loci were situated in genomic regions with enhancer activity , distant from gene bodies and promoters.
The genomic convergence approach has been used to implicate the gene MMP20 in human kidney ageing.
The genomic region marked by rs855203 may consequently be of significance for further molecular and pharmacogenetic research , in particular in advanced age.
The genotype and allele distributions of the BChE-K were determined by polymerase chain reaction and subsequent DNA sequencing.
The genotype frequencies of LRP5 gene polymorphism were @number@ @number@ and @percent@ for AA , AV , and VV , respectively.
The genotypes of the COMT Val158Met polymorphism were determined using polymerase chain reaction plus restriction fragment length polymorphism analysis.
The genotype treatment interaction was statistically significant for both gait speed ( P = @number@ ) and SPPB ( P = @number@ ) .
The genotyping was performed using a polymerase chain reaction ( PCR ) with confronting 2-pair primers ( CTPP ) assay.
The genus Faecalibacterium was depleted , while Lactobacillus was enriched in the gut microbiota of older HF patients.
The geographic distribution of pediatricians showed rapid concentration in urban areas.
The geographic origins of populations can be identified by their maternally inherited mitochondrial DNA ( mtDNA ) haplogroups.
The geographic trends observed in hip fracture incidence rates can provide important clues to etiology and prevention.
The geometric properties of the femur influence femoral strength and fragility , but differences in femoral geometry according to age and ethnicity are poorly understood.
The geometry as well as bone mineral density ( BMD ) of the proximal femur contributes to fracture risk.
The geometry of the tensors was quantified pixel-wise by decomposing the tensor in sphere-like , plane-like , and line-like components.
The Geriatric Academic Career Award ( GACA ) was a vital resource that benefitted @number@ junior faculty members.
The geriatric drug guidelines included a list of medicines suitable for the elderly ( conformity list ) and recommendations for prescription and monitoring.
The Geriatric Emergency Medicine Competencies ( GEMC ) are high-impact geriatric topics developed to help residencies efficiently and effectively meet this training demand.
The geriatric faction of the surgical population is increasing , and malnourished , critically ill geriatric surgical patients have worse outcomes.
The Geriatric Mental State Automated Geriatric Examination for Computer Assisted Taxonomy and the Cambridge Cognitive Examination were used to determine cognitive status.
The Geriatric Mental State-Automated Geriatric Examination for Computer Assisted Taxonomy was used to measure dementia.
The Geriatric Oral Health Assessment Index ( GOHAI ) was administered to evaluate OHRQoL.
The geriatric patient may have several incurable , but treatable , chronic diseases that affect their skin.
The geriatric population ( age @number@ and older ) is the fastest growing segment nationally and globally.
The geriatric population is more prone to pressure ulcers , venous stasis ulcers , and other chronic wounds.
The Geriatric Resource Nurse model is the foundation of the program.
The geriatric resource nurse model was used to achieve a reduction in falls through standardized delirium screening and implementation of fall prevention strategies.
The geriatric syndromes include a wide variety of disease processes ranging from incontinence and dementia to impairments in physical function.
The geriatric trauma patient is becoming an increasingly important cohort for trauma services.
The German and the United States survival estimates were compared using the Surveillance , Epidemiology and End Results @number@ database.
The German health care system needs to adjust its services-linguistically , culturally , and medically-for this subpopulation of patients.
The GFAL project results can serve as a model for sustainable , community-based older-adult exercise programs.
The GFAP ( @number@ ) isoform defines a unique subset of astrocytes , with numbers increasing with AD progression.
The GFR was estimated with six modified GFR prediction formulae.
The GG gene variant is expected to be more active than the GA or AA gene variant.
The GG genotypes of rs16835198 were associated with increased HbA1c and FPG in the low-fitness group only ( p < 0.05 ) .
The GGGGCC-hexanucleotide repeat expansion in C9orf72 is the most common genetic cause of familial amyotrophic lateral sclerosis and frontotemporal dementia.
The GGGGCC hexanucleotide repeat expansion of the C9ORF72 gene was present in @number@ ALS patient.
The GH / IGF-I axis has essential roles in regulating bone and vascular status.
The GHPSS questionnaires were self-administered via a special website which is created ad hoc for the survey.
The GHQ-28 was used as a screening tool for mental disorders.
The GHRD group showed enhanced cognitive performance and greater task-related activation in frontal , parietal , and hippocampal regions compared with controls.
The giant exercising board game required participants to per-form strength , flexibility , balance and endurance activities.
The GI epithelium also contributes to poor permeability for numerous drugs.
The Giessen Test was standardized in a representative German sample in @number@
The GI is a kinetic parameter that reflects the ability of carbohydrate ( CHO ) contained in consumed foods to raise blood glucose in vivo.
The ginsenoside content of EG was measured by liquid chromatography-mass spectrometry ( LC-MS ) .
The GIOG promotes the development of a clinic database with the aim of obtaining a qualitative improvement in the management of hip fracture.
The GIP correlations with the MMSE and CDR were @number@ and @number@ respectively ( p < @number@ ) .
The GIST of concepts.
The given reference ranges of plasma lipids can assist in early identification of individuals with hypocholesterolemia and hypercholesterolemia , especially familial hypercholesterolemia.
The glabella is in fact , the most common site for botulinum toxin injection in Asians.
The glabellar and maxillary angles decreased significantly with age for both sexes , whereas the pyriform aperture area significantly increased for both sexes with age.
The glabellar rhytid has not only dynamic but also static cause , which is usually achieved by injection of filler.
The glands are not pathological and represent an age-related alteration that occurs with or without the presence of the mouth floor enlargements.
The glands have roundish , oval , ribbon forms.
The glands were investigated with the application of stereo binocular microscope MBS-9.
The glass transition temperatures are taken from the peak of the tangent tanδ versus temperature curves.
The glazed and non-glazed specimens were further divided into two groups.
The glazed specimens were then conditioned with @percent@ HF acid gel for @number@ s , rinsed with water for @number@ s , and neutralized.
The glaze group showed the highest shear bond strength.
The glenoid growth plate fused by @number@ years of age.
The Gln203Stop mutation , located in KL1 domain , was severely hypomorphic and led to a 17-fold reduction of renal Kl expression.
The global aesthetic improvement scale ( GAIS ) and a novel questionnaire were used to assess subject treatment satisfaction.
The global annualized rate of GM atrophy remained constant throughout the age range of the cohort , in both sexes.
The global annualized rate of GM was @number@ cm3 / year ( @number@.83% / year ) .
The global burden of cancer continues to increase largely with the aging and growth of the world population.
The global burden of cancer is increasing.
The Global Burden of Disease Study @number@ ( GBD @number@ ) documented that ischemic heart disease and stroke collectively caused one in four deaths worldwide.
The global burden of IHD increased by @number@ million disability-adjusted life-years ( @percent@ increase ) between @number@ and @number@
The global economic burden of HF is not known.
The global NPI score evolution was assessed using a linear mixed-effect model.
The global obesity epidemic enhanced contemporary interest in adipose tissue biology.
The global population is ageing.
The global population is aging.
The global population is aging , and with that comes new challenges.
The global population is aging , with the over-65 age group expected to double in the USA by @number@
The global prevalence of chronic kidney disease ( CKD ) is rising , particularly among the elderly population.
The global prevalence of dementia is as high as @number@ million , and has been predicted to quadruple by the year @number@
The global prevalence of diabetes mellitus has reached epidemic proportions.
The global prevalence of obesity has grown to epidemic proportions , and @number@ million people are now considered to be obese.
The global PWV was found to increase nonlinearly with age.
The global shift in demographics towards aging populations is leading to a commensurate increase in age-related disease and frailty.
The global trend towards increased longevity has resulted in ageing populations and a rise in diseases or conditions that primarily affect older persons.
The globus pallidus receives the dopaminergic input from the substantia nigra and plays a key role in motivation which is critically linked to dopamine.
The Glogau classification system score demonstrated a mean reduction of @number@ ( @number@ preoperatively as compared with @number@ postoperatively , p < 0.0001 ) .
The GLP-1 response normalizes within @number@ year after surgery.
The GLP-1 response to G3 was much greater ( P < @number@ ) than to G2 and G1.
The glucocerebrosidase gene ( GBA ) is a known risk factor of Parkinson's disease ( PD ) .
The glucose-lowering effect of IDeg was numerically lower in elderly subjects compared with younger adults , but no significant differences were observed between age groups.
The glutathione S-transferase mu-1-null genotype strengthened the association between BC and Alu hypomethylation.
The GL was defined as a vertical line drawn through the centre of vertical pressure measured by the force plate.
The glycemic index ( GI ) indicates how fast blood glucose is raised after consuming a carbohydrate-containing food.
The glyoxalase @number@ gene is also a site of copy number variation in both transcribed and non-transcribed regions giving rise to population variation of expression.
The glyoxalase system and Glo1 expression particularly is therefore likely linked to healthy ageing.
The glyoxalase system has been studied since @number@
The GM group showed better results for the peak torque and work than the GS group , but without statistical significance.
The GMS scheme covers approximately @percent@ of the Irish population in @number@ and entitles them , inter alia , to free prescription drugs and appliances.
The GM volume ROI was not a significant predictor ( p = @number@ ) .
The goal for this study was to examine within-person processes driving individual development related to social goals.
The goal here was to better understand the relationship between well-being and environmental factors and their influence on hypertension.
The goal is to function at the optimum state , or to return to that optimum state.
The goal is to help practitioners who work with older people with cognitive impairments to accurately assess their ability to manage themselves and their property.
The goal is to produce a deeper wound healing response at multiple levels with robust collagen remodeling and a more durable clinical response.
The goal is to restore the natural youthful appearance rather than to create an effect that differs from the patient's appearance earlier in life.
The goal is to track changes in psychophysiological characteristics of cognitive functions associated with the transition of the elderly in the senile.
The goal of orthopaedic care in the elderly patient is shifting from simple pain relief toward return to athletic activity.
The goal of short-term training programs is to whet the students ' appetite for research and spark their interest in the field.
The goal of the intervention is to achieve blood pressure control defined as SBP < @number@ mm Hg and DBP < @number@ mm Hg.
The goal of the present study was to identify the cognitive components underlying fluency performance.
The goal of the present study was to investigate the role of sensory modality in age-related vulnerability to distraction , using a response interference task.
The goal of these studies is to quantify biological shape variability within and across individuals , and also to distinguish between normal and disease populations.
The goal of the study was to analyze the association between endothelial dysfunction , evaluated by asymmetric dimethylarginine ( ADMA ) levels , and frailty.
The goal of the treatment is to return the patients to their pre-fracture level of quality of life and avoid complications during the surgery.
The goal of the two experiments described in this article was to explore the relationship between gap acceptance and TTA estimation.
The goal of this article is to critically review published studies to determine if there is a role for DHEA supplementation in postmenopausal women.
The goal of this article is to provide a systemic approach to forehead rejuvenation.
The goal of this article is to synthesize findings of existing longitudinal studies through a meta-analysis.
The goal of this paper was to review specific considerations for balancing efficacy and safety in the pharmacologic treatment of persistent pain in older adults.
The goal of this pilot study was to examine MRI- and magnetic resonance spectroscopy ( MRS ) -derived hippocampal correlates of pain in older adults.
The goal of this qualitative study was to better understand the barriers to and facilitators of PA and participation in PA programs among older adults.
The goal of this report is to describe recent findings to help elucidate remaining questions.
The goal of this review is to explore the benefits of considering older adults in the study of personality disorders.
The goal of this study is to describe and quantify the rate and extent of age-related submandibular gland ptosis.
The goal of this study is to understand the biomechanical properties of the pelvic floor tissues of young women and the impact of aging.
The goal of this study was to assess plasma miRNA profiles and to identify plasma miRNAs that are differentially expressed in patients with heart failure.
The goal of this study was to assess the age-dependent changes of the SC barrier function and the associated physiological parameters.
The goal of this study was to characterize and compare the biomechanical properties of aged human and porcine aortic tissues.
The goal of this study was to compare the content of elastin in the rectus muscle sheath of obese patients and nonobese controls.
The goal of this study was to determine if dietary nitrate would increase cerebral blood flow in older adults.
The goal of this study was to determine whether cord blood ECFCs from GDM pregnancies exhibit altered functionality.
The goal of this study was to determine whether there is any influence of patient's sexual gender on occurrence of that hematoma.
The goal of this study was to evaluate the effect of a neighborhood-changing intervention on changes in obesity among older women.
The goal of this study was to examine perceived financial preparedness for retirement and its correlates.
The goal of this study was to examine the relationship between BP variations and neurological deficit outcome in old-old patients after AIS.
The goal of this study was to examine whether altered cerebral hemodynamics in depressed elders predicted antidepressant response.
The goal of this study was to identify factors associated with purchasing cigarettes from cheaper sources among adult smokers in China.
The goal of this study was to identify preoperative factors associated with decreased survival for older patients who underwent resection of a GBM.
The goal of this study was to investigate dysphonia in this cohort.
The goal of this study was to investigate individual and contextual factors associated with dental care utilization by U.S. informal caregivers.
The goal of this study was to investigate the effects of aging on pointing movements under restricted visual feedback of hand movement and target location.
The goal of this study was to obtain a comprehensive picture of nutritional status in SOP patients.
The goal of this study was to systematically investigate age-related changes of the limbic system using measures of cortical thickness , volumetric and diffusion characteristics.
The goal of this study was to test that hypothesis.
The goal of this study was to verify the anatomical relationship between the sagittal suture and the superior sagittal sinus ( SSS ) .
The goal of this work was to investigate changes in spatial distribution and microstructure of cortical porosity associated with aging in men and women.
The goal of treatment of osteoporosis is fracture prevention.
The goals of earlier diagnosis and individualized treatment of bipolar disorder were endorsed.
The goals of pharmaconutrition for metabolic optimization are to drive biochemical reactions in a desired direction and to meet health condition-specific metabolic demands.
The goals of this study are twofold.
The goal was to examine risk factors for hospitalization for an ACS condition of Medicaid-enrolled younger and older ALF residents during 2003-2008.
The goal was to survey how patient age influences the development of glaucoma.
The goiter volume was measured by ultrasound ( no. = 127 ) , or by magnetic resonance imaging ( no. = 43 ) .
The golden hamster is an excellent animal experimental model for oocyte research.
The gold standard for diagnosing Ps. aeruginosa infection was a positive sputum culture.
The Gompertz model for spontaneous mortality and gamma-frailty model for heterogeneity are used.
The Gompertz model is well known and widely used in many aspects of biology.
The Gompertz relationship fits age trajectories of all-diseases mortality in @number@ out of @number@ cases.
The goodness of fit and discrimination were assessed for model performances.
The good variability does not affect the COM position , while the bad variability does.
The Google Scholar keyword search had low precision ( @percent@ ) but provided the highest sensitivity ( @percent@ ) .
The governor of Caen prison and two inmates describe the reality of the detention of elderly people.
The GP cohort significantly underestimated the average length of postgraduate training ( five years ) to become a vascular surgeon.
The GPs indicated that social therapeutic options are seen to be as effective as pharmacological options and more effective than other psychological and bibliotherapy options.
The GPs suggested that lower waiting times and a more localised service would increase the likelihood of a referral being made.
The Gpx6 gene was upregulated while the Txnrd1 gene was downregulated with age / hearing loss.
The Gpx6 , Txnrd1 and Hspb1 gene expression changes were validated using qPCR.
The grade and the frequency of tau protein deposition were increased in accord with aging.
The grade of nuclear opalescence or cortical opacity was assessed using the Lens Opacities Classification System III ( LOCS III ) .
The grades of SLIL or LTIL did not correlate with the morphology of the lunate , the SL gap or the SL angle.
The gradient measure of contextual probability ( derived from a separate offline rating study ) affected the speed of recognition.
The grading and staging of histopathologic findings were performed according to the Brunt method after reevaluation of the slides by a pathologist.
The gradual accumulation of DNA damage is thought to contribute to the functional decline of tissues and organs with ageing.
The gradual alterations in protein homoeostatic response are accompanied by Schwann cell de-differentiation and macrophage infiltration.
The gradual , irreversible loss of dopamine neurons in the substantia nigra is the signature lesion of PD.
The gradual programmed decrease of the level of bioenergetics causes the slow and coordinated attenuation of all physiological functions , i.e. aging.
The gradual removal of the tolerogenic effect of HBeAg leads to the awakening of the immune response ( immune clearance phase ) .
The granting of APA is a decentralized process , with @number@ County Councils ( CC ) managing it , with wide room for local interpretation.
The graphical user interface provides biologists with a practicable and reliable way to analyze and visualize epigenetic difference.
The graying prison population is also straining state and local budgets.
The greater axial lengths were counterbalanced by both lower corneal and lower lens powers.
The greater instability in elderly participants , despite their comparable movement characteristics , emphasizes the importance of stability control following sit-to-stand performance.
The greater jitter for older speakers indicates a decrease in the stability of the vocal production mechanism of the older speakers.
The greater peak force error in older adults was associated with changes in the activation of the ADM muscle but not the FDI.
The greater the support network , the greater the amount of perceived happiness ( @number@ OR ; 5-9 95%CI ) .
The greater tuberosity cortex and greater tuberosity subcortex outcome measures were similar.
The greater WM atrophy in EOAD than LOAD fits with the evidence that EOAD is a more aggressive form of the disease.
The greatest 3-month improvement for both programs was in hyperpigmen- tation.
The greatest attenuation of these results was seen by height , parental social class and smoking , especially among the under 65s.
The greatest barrier to being sexually active at an older age is lack of a partner , which particularly affects women.
The greatest burden was found in Poland , where direct costs were over EUR @number@ million.
The greatest cause of fracture in older people is osteoporosis which contributes to increased morbidity and mortality in older people.
The greatest challenge in the biology of ageing is to now identify the mechanisms underlying increased healthy lifespan in these model organisms.
The greatest decrease was assessed at the forehead.
The greatest differences were found for neuroimaging ( @percent@ in PC vs. @percent@ in SC ) and clock tests ( @percent@ vs. @percent@ ) .
The greatest effect was observed in HER2 + breast cancer with an increase in patients achieving pCR from @number@ to @number@ %.
The greatest improvement in photodamage measures following @number@ MAL-PDT were pigmentation , AK and erythema.
The greatest improvement was seen in tonsillar and tongue cancers.
The greatest incidence rates increase ( @percent@ ) occurred in the northeast , a less developed region that has recently achieved significant economic advances.
The greatest overall improvement is the extent of midface ptosis and infraorbital hollowing at the lower eyelid-cheek junction followed by improvement in the nasolabial region.
The greatest relative contribution to predicting individual brain maturity was made by the weakening of short-range functional connections between the adult brain's major functional networks.
The greatest risk factor for AD is aging.
The greatest risks of postoperative stroke , respiratory , and cardiac complications were found in patients with CKD.
The greatest transition to sarcopenia ( @percent@ ) was in presarcopenic individuals.
The great increase in the number of patients with chronic kidney disease ( CKD ) can be explained by a number of reasons.
The great number of fillers on the market is composed of a large heterogenic number of biomaterials.
The Great Recession has brought along a rearrangement of living patterns both in the U.S. and in Europe.
The grip force and the object's acceleration were recorded and used to calculate the parameters of grip force control.
The grounded theory approach was used to identify a process model of older people's perceptions and experiences of living with chronic pain.
The group believes that the efficiency of its actions is limited due to the lack of transport and other professionals.
The group consisted of blood donors and patients undergoing regular preventive examinations.
The group mean PA was @number@.6° ± @number@.1° ( @number@.4°-9.2° ) .
The Group @number@ ( n = @number@ ) patients received lifestyle modifications ( diet and exercise ) , and medical treatment for intensive glycemic control.
The group of Alzheimer's patients were impaired in all experimental tests as compared to healthy participants.
The group of elderly drivers with suspected deficits in driving skills also underwent a medical examination and a practical on-road driving test.
The group of interest were those aged 50-75 who had retired early.
The groups A , B and C were treated with PESF.
The groups also differed in health variables related to PTSD symptoms.
The groups cleaned using alcohol only showed low bond strength values in dry conditions and the bond strength was reduced dramatically after aging.
The groups compared were statistically similar in age , sex , education level and comorbidity score.
The groups did not differ in total sleep time.
The groups did not differ on daily step counts or 6-minute walk performance.
The groups showed equivalent levels of global disability.
The groups significantly ( p < 0.05 ) differed on NSL and MAC-Q difference scores.
The groups were approximately matched on immediate test ; both showed systematic forgetting which was particularly marked in the elderly.
The groups were compared using t-tests and the relations between measures using correlation coefficients.
The groups were generally satisfied on most measures of work , with PAs more satisfied than NPs on some measures.
The groups were matched on a range of relevant cognitive test scores and on the established CR variables of education , socioeconomic status and intelligence.
The groups were selected on the basis of anamnesis , physical examination and nutritional assessment according to the Mini Nutritional Assessment ( MNA ) score.
The groups were similar regarding EF , proBNP and FC.
The group under treatment with atypical antipsychotics was further subdivided according to the risk of medication to cause metabolic syndrome ( MetS ) .
The group was well below average across multiple neurocognitive domains , and @percent@ had required accommodations at school for learning disorders.
The group , who underwent parathyroidectomy associated with thyroidectomy , had no greater complications than the group receiving only parathyroidectomy.
The growing consensus that ageing is driven by a limited number of interconnected processes suggests an alternative approach.
The growing elderly population worldwide highlights the need to understand how aging promotes CVD in order to develop new strategies to confront this challenge.
The growing follicles develop from a reserve of primordial follicles constituted early in life.
The growing influx of patients in healthcare providers is the result of an aging population and emerging self-consciousness about health.
The growing interest and knowledge in the field of microRNAs adds a further dimension to this field of research.
The growing need to better understand both aging and neurodegenerative processes has led to the development of simple eukaryotic models amenable for mechanistic studies.
The growing number of dementia patients leads to both policy , economic and health organization constraints.
The growing number of older people will probably lead to increased demands for nurses working in elderly care.
The growing number of the older people and changing morbidity patterns will obviously influence both the entire society and the health care system.
The growing prevalence of maternal obesity , gestational diabetes , childhood obesity , and early-onset disease can lead to premature morbidity and mortality.
The growing recognition of the social determinants of health has stimulated research on social capital and mental health.
The growing scenario of economic shortages in heath care system seems to further legalize the social prejudice and the ageistic discrimination towards elderly with disability.
The growing societal and individual burden of dementia means that counting the cases of dementia is critical.
The growth arrest is a potent anticancer mechanism whereas the secretome facilitates wound healing , tissue repair , and development.
The growth curves showed active proliferation for 8-10 passages with a consequent gradual decrease of proliferative activity , which ended to 20th passage.
The Growth Hormone / Insulin like growth factor-1 axis could play a role in the development of IR during sleep disorders.
The growth in testosterone's reputation and its increased use by men of all ages has seemed to outpace the scientific evidences.
The growth in the ageing population has created a new health scenario in which there is a higher prevalence of frailty and multimorbidity.
The growth of highly vascularized tumors in PLK3-null mice suggests a role for Plk3 in angiogenesis and cellular responses to hypoxia.
The growth of the Brazilian elderly people has led to a trend to an increase in the medication use.
The growth of the pregnant uterus and increase in content of myofibrillar proteins , may abolish any previous age-related force deficit.
The growth of tumors in a mouse peritoneal cavity was intensified when the cancer cells were co-injected together with senescent HPMCs.
The growth period is crucial to skeletal development and results in larger bones in males than in females.
The growth rates of allograft LLC cells were also reduced by ARE treatment.
The gSG6 protein was immunogenic and anti-gSG6 IgG levels and / or prevalence increased in exposed individuals during the malaria transmission / rainy season.
The GTPases are one of the signaling molecules that activate crucial signal transducing pathways downstream of Ras through several effector proteins.
The guidelines are based on an analysis of natural history studies of AS and risk and durability of AVR.
The guidelines for the classification of reproductive aging stages proposed at the Stages of Reproductive Aging Workshop were used.
The guidelines for the management of urticaria in adults and children have been revised and updated recently.
The guidelines reflect this uncertainty , providing no clear indications , even in the gradation of severity of the FMR.
The guidelines were approved by the National Nutritional Council in Finland.
The guidelines were developed for primary physicians as well as patients and the general population.
The guidelines were elaborated according the Haute Autorite de Sante methods by a multidisciplinary working group comprising experts and practitioners.
The Guidelines were externally reviewed by a panel of experts.
The guiding hypothesis is that the magnitude of adaptation after @number@ weeks will be greatest in those initially randomized to RSTS.
The GUI of ViSiBooL allows to model , organize , simulate and visualize BNs as well as corresponding simulation results such as attractors.
The Gulf Advocate Group recommends following the U.S. Centers for Disease Control and Prevention ( CDC ) guidelines for pneumococcal vaccination [ @number@ ] .
The Gunning Fog Index was used to determine the readability of the PILs to older adults.
The gunpowder age is information of great importance that could help to establish safety regulations related to the propellants use and manipulation.
The gut microbiome is increasingly recognized as having an important role in human health and disease.
The gut microbiota and host immune system co-evolve from infants to the elderly.
The gut microbiota is the assembly of microorganisms living in our intestine and their genomes are known as the microbiome.
The GVI of OA ( @number@.92±8.75 ) was significantly lower compared to the GVI of YA ( @number@.79±7.99 ) .
The H3.3 histone variant has been a subject of increasing interest in the field of chromatin studies due to its two distinguishing features.
The HAALSI cohort was established to investigate the impact of these interactions on CMD morbidity and mortality among middle-aged and older adults.
The habit-training process-dissociation was used to explore the cognitive mechanisms underlying memory slips to separate the contribution of habit and recollection to memory performance.
The habitual PM task involved pressing a button twice daily ( Bed-time , Rise-time ) on the actigraph.
The hAECs may be a candidate seed cell for liver regeneration.
The HA film created in this study demonstrated excellent microstructural and mechanical properties , even after the application of thermal stress.
The hair cuticles in the children and young adult groups were relatively complete and less damaged than in the elderly group.
The hair status was further considered according to nonalopecic and alopecic patterns and severity ( discrete , moderate , and severe ) .
The hair was then clipped into the uniaxial tensile testing device.
The hallmark pathological feature in most cases of ALS is nuclear depletion and cytoplasmic accumulation of the protein TDP-43 in degenerating neurons.
The hallmark pathology of AD consists of pathological aggregates of amyloid-β ( Aβ ) peptides and tau proteins.
The hallmarks of an AD brain include plaques comprising of extracellular beta-amyloid ( Aβ ) protein aggregates and intracellular hyperphosphorylated neurofibrillary tangles of tau.
The hallmarks of IPF are aberrant activation of alveolar epithelial cells and accumulation of fibroblasts and myofibroblasts along with excessive production of extracellular matrix.
The hallmarks of sporadic Alzheimer's disease ( AD ) are extracellular amyloid deposits , intracellular neurofibrillary tangles ( NFTs ) , and neuronal death.
The hallmark symptom of sarcopenia is the loss of muscle mass and strength without the loss of overall body weight.
The Hamilton Depression Rating Scale and Young Mania Rating Scale were used to evaluate clinical response during weeks @number@ @number@ @number@ @number@ @number@ and @number@
The hamster oocytes are very useful in clinical examination of human spermatozoan activity.
The Handgrip Test ( HT ) and the 6-Minute Walk Test ( 6MWT ) are used to assess physical fitness in the elderly.
The HA particles in the deposited film were densely packed , and the surface of the HA film was unchanged after thermal cycling.
The HAP is a useful indicator of physical activity levels in older women.
The haplogroup was assigned through a combination of sequencing and PCR-RFLP techniques.
The haplotype block of this @number@ Kb region was different between Caucasian and Japanese.
The happiest elders were more likely to be home-dwelling elders ; however , there were fewer unhappy elders among those who were institutionalised.
The hardness and elastic modulus of the young adult group's hair samples were higher than those in the elderly and children's groups.
The harmful cumulative dose of sunlight is not the risk factor but the cause , including the inheritance , for AMD development.
The harmonization of outlines and the trophicity are preserved , which gives a much more natural aspect.
The Harvard Aging Brain Study is sharing its data with the global research community.
The HA score was significantly correlated with sex , age and VEGF level , and single and multiple regression analyses yielded the same results.
The hASC were intravenously injected into the tail vein of a PD mouse model induced by 6-hydroxydopamine.
The HAS declined with increasing age for both sexes , albeit slightly steeper in women.
The Hasegawa Dementia Scale-revised ( HDS-R ) and the Mini-Mental State Examination ( MMSE ) are widely used in Japan to screen for dementia.
The Hasegawa Dementia Scale-Revised score of AD subjects ranged from @number@ to @number@
The HASs also contain variants associated with exceptional longevity , based on a separate analysis.
The HAS was strongly associated with mortality in both sexes.
The Haversian canal area was higher in the infero-posterior area compared to the postero-superior area ( P = @number@ ) .
The Hawai'i State Center for Nursing collects ongoing data on the nursing workforce to inform strategic planning.
The HA was administered into the preperiosteal tissues with a serial puncture technique and approximately @number@ mL was injected at each pass.
The hazard rates followed an exponential trend , indicating a rapid increase in health impairments in particular beyond @number@ yrs of shiftwork.
The hazard ratios obtained from each cohort were subsequently pooled by meta-analysis.
The hazard score was calculated for these men to test prediction of survival free from PCa.
The HCE group experienced significantly greater weight loss ( @number@ ± @number@ vs. @number@ ± @number@ kg , p < @number@ ) .
The HC group tended to be younger , with higher educations , and more likely to live in urban area than the Functional Impairment group.
The HCT-comorbidity index ( HCT-CI ) has provided better prediction of HCT-related morbidity and mortality than other non-HCT-specific indices.
The HD initiation and death-associated changes were also analyzed using generalized additive mixed models.
The HDS-R was applied to subjects with MCI and dementia.
The Head-Shake Sensory Organization Test ( HS-SOT ) has been developed to improve the delineation of balance performance.
The heads of departments were also asked for their opinion and suggestions on management , projects and future.
The heads of @number@ Japanese cadavers ( @number@ male cadavers , @number@ female cadavers ) autopsied in our department were used in this research.
The heads of the IMD identify problems in their relationship with hospital managers , other specialties and local population.
The healing effects that wheat complex can have on damaged hair are also addressed.
The healing rate of PU is improved with Arginaid Water supplementation.
The healing rate was determined macroscopically @number@ @number@ and @number@ days later.
The Health Belief Model was used as the study's theoretical framework.
The health benefits of sport and physical activity and the health risks of inactivity are well known.
The health benefits of the Mediterranean diet can be largely ascribed to the nutraceutical properties of extra-virgin olive oil ( EVOO ) .
The health benefits of this type of activity pattern remain unclear.
The health burden from heatwaves is expected to increase with rising global mean temperatures and more extreme heat events over the coming decades.
The health burden of osteoporosis in men is expected to increase with an aging population and increasing life expectancy.
The health care cost of smoking was $ 662 million for the Hispanic community.
The healthcare costs and quality-of-life scores were determined at the follow-up examination.
The healthcare costs for women and men were $ 877.1 million and $ 294.3 million , respectively.
The health care environment in the U.S. is changing.
The health care needs of elderly people were influenced by their heterogeneity.
The health care products and services should be centered on the needs of older adults.
The healthcare provider landscape is rapidly changing.
The health care system is further complicated by a shortage of highly trained nurses , challenging financial incentive models , and inefficient traditional staffing models.
The health economic consequences associated with the choice of second-line treatment in older patients were assessed using the CORE Diabetes Model.
The health education control group will meet one time per week for two 2h per session.
The health effects are present for up to more than @number@ years before a diagnosis of PD / AP.
The health effects of increased body mass index as a child may significantly impact obese youth as they age.
The health effects of resveratrol in cardiovascular diseases , cancer and longevity are an area of active research.
The health effects were present in all age groups and in both genders.
The health gain resulted from earlier diagnosis and access to first-line curative treatments , among which RFA provided the best value for money.
The healthier metabolic profile is related to obesity in an age-dependent fashion.
The health implications of physical inactivity , including its integral role in promoting obesity , are well known and have been well documented.
The health indicators derived from these survey data are self-rated general health , overall health state , quality of life and disability levels.
The health of individuals is highly heterogeneous , as is the rate at which they age.
The health of older people is a priority in many countries as the world's population ages.
The Health of the Retina index ( HRindex ) was computed to capture the loss of contrast sensitivity with decreasing light level.
The health outcomes selected were observed to be inconsistent between studies.
The health professionals reported significantly higher on search other sources than the students.
The health profile differed by gender and ethnicity.
The health sector alone cannot solve this problem.
The health status of elderly people includes a variety of health indicators.
The health status of older people is frequently complicated by one or more chronic diseases.
The health systems as well as healthcare structure and provisions vary considerably.
The Health Visitor Implementation Plan published by the Department of Health in England in @number@ aimed to expand and strengthen health visiting services nationwide.
The Healthy Ageing Model is anchored in established theory on motivation and health behaviour change.
The Healthy Aging Index ( HAI ) may be a subphenotype of longevity , which can be constructed in many studies for genetic analysis.
The Healthy Aging Index ( HAI ) was recently developed to describe a wider range of health and disease across multiple organ systems.
The Healthy Eating Index-2010 ( HEI-2010 ) was calculated to quantify diet quality.
The healthy fat intake is likely one mechanism for reducing inflammation , optimizing cholesterol , and other risk factors.
The Healthy Foods cluster also had significantly more years of healthy life and more favorable levels of selected nutritional biomarkers than the other clusters.
The healthy life expectancy , life expectancy free of disability and life expectancy with disability in the older adult analysis was highlighted.
The hearing aid industry should strive to design signal processing algorithms that are cognition friendly.
The Hearing Handicap Inventory for the Elderly ( HHIE ) score was significantly elevated among these @number@ participants.
The hearing loss is connected to age-related histologic changes , as described and classified by Schuknecht.
The hearing threshold levels in the present study were higher ( poorer ) than the ones provided by ISO @number@ ( @number@ ) .
The hearing thresholds at two time points were compared at each frequency and in two different frequency regions.
The hearing threshold shift was more pronounced in the high-frequency region , especially at @number@ Hz.
The heart and the kidney are of utmost importance for the maintenance of cardiovascular ( CV ) homeostasis.
The heart begins to beat before the brain is formed.
The heart is a muscle with high energy demands.
The heart is a very special organ in the body and has a high requirement for metabolism due to its constant workload.
The heart is highly energy dependent with most of its energy provided by mitochondrial oxidative phosphorylation.
The heart is the first organ formed during mammalian development.
The heart rate and cardiac output increase , and total peripheral resistance reduction following exercise were not different among RE protocols.
The heart rate , stroke volume , and cardiac output significantly increased during the stimulation.
The heart-to-mediastinum ratios of 123I-MIBG uptake were also calculated using an automated region-of-interest based system.
The heart transplantation for indicated patients is still gold standard surgery although the 10-year survival rate is approximately @percent@ based on the worldwide data.
The heat stress cognate @number@ is one of the major cytoplasmic chaperones to supply a multitude of the housekeeping chaperoning functions.
The hedonism effect is partially associated with the fact that individuals holding hedonistic values are in good health.
The height loss values were divided into quartiles ( Q1-Q4 ) for men and women.
The height of L4 did not increase over time , but the L4 width did increase.
The height of PPVP at the fovea was @number@ ± @number@ µm in children and @number@ ± @number@ µm in adults.
The height , weight , body mass index ( BMI ) , the percentage of body fat ( BIA ) were also measured.
The HeLa and MS751 cells were significantly more sensitive to ginsenoside-Rg5 treatment compared with the C-33A , HT-3 and Me180 cells.
The hemagglutinating activity of this hemagglutinin was demonstrated to be ion dependent and stable over a wide range of temperature and pH values.
The hematopoietic cells were of mixed lineage , but one type , often erythroid , predominated.
The hematopoietic system has the remarkable ability to provide a lifelong supply of mature cells that make up the entire blood and immune system.
The hemispheres of the human brain are functionally and structurally asymmetric.
The hemodynamic changes did not differ between sexes or between surgical and non-surgical etiologies of vocal fold paralysis.
The hemodynamic monitoring is recommended so that timely intervention can be applied in case any warning sign occurs.
The hemodynamic reference values obtained suggest that the diagnostic threshold for abnormal filling pressure should be individually determined according to age of the patient.
The hemolytic compounds in the ECS strain were extracted and analyzed.
The hemolytic , ichthyotoxic , and cytotoxic activities of the algae was characterized.
The hemostatic system is incompletely developed at birth and matures throughout infancy.
The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution.
The hepatitis C virus ( HCV ) , a major cause of chronic liver diseases worldwide , has been described to induce autophagy.
The hepatotoxic effects of ethanol undermine the contribution of malnutrition to the liver injury.
The HE program featured health-related discussions and a brief upper body stretching routine.
The hereby-detected age-associated and consistently coexpressed PPI modules therefore may provide a molecular basis for future research into mechanisms underlying human aging.
The heritability of age at death in adulthood is approximately @number@ %.
The heritability of borderline personality ( BP ) features has been established in multiple twin and family studies.
The heritability of lifespan estimated across most studies has been rather low.
The heritability of Δage was @number@
The heritability was significant on each of the @number@ occasions and ranged from @number@ to @number@
The heritage of the nursing home as the dominant model for LTC needs to be reexamined.
The heterogeneity among studies were examined by using Cochrane's Q statistic and I-squared.
The heterogeneity and the complexity of the older old population represent the main challenge to the treatment of cancer in those patients.
The heterogeneity of assessment methods and outcome measurements lead to inconsistent results.
The heterogeneity of life courses and migration trajectories should be taken into account when developing public policies.
The heterogeneity of the methods used to measure IS precluded meta-analysis.
The heterogeneous nature of this transition appears to be due to differences in socio demographic factors.
The heterozygosity of the same SNP was seen in 2 / 63 men from the HBS-cohort ( MAF @number@ ) .
The heterozygous mutation observed in exon @number@ resulted in a valine to alanine substitution at position @number@ in the β-barrel domain of the SOD1 protein.
The hexonucleotide repeat expansion ' GGGGCC ' at the C9ORF72 gene has been strongly linked with amyotrophic lateral sclerosis and frontotemporal dementia.
The hexosamine biosynthesis pathway ( HBP ) regulates the post-translational modification of nuclear and cytoplasmic protein by O-linked N-acetylglucosamine ( O-GlcNAc ) .
The HF183 marker exhibited decay rates of @number@ to @number@ day Human CAXII was initially identified as a cancer marker in different cancers and tumors.
The HFE gene appears to be a genetic risk factor for severe aging WML independently of the APOE ε4 genotype.
The HFP results also showed a significant correlation with age , consistent with senescent increases in short wavelength absorption by the crystalline lens.
The HF subjects had more sleep apnea and higher occurrence of heart rate non-dipping.
The HGS was measured twice : at hospital admission and discharge.
The HHV-8 test was positive , with positive polymerase chain reaction-HHV8 in the serum and skin.
The hierarchical cluster analysis was then performed to identify possible patient profiles.
The hierarchical control from the central clock to peripheral clocks extends to other functions including endocrine , metabolic , immune , and mitochondrial responses.
The hierarchy logistic regression analysis was applied to estimate the risk of independent variables for urinary incontinence among respondents.
The HIF-1a protein interacts with c-Myc , decreasing c-Myc-regulated transcription of the key mitochondrial regulator mitochondrial transcription factor A ( TFAM ) .
The HIF-1α , AR , VEGF , and IL-8 were upregulated under @percent@ O2.
The high accumulations of these minerals may be induced by eating large amounts of sheep meat.
The high average VHI score indicated that these geriatric patients experienced significant dissatisfaction because of their dysphonia.
The high blood pressure-lowering effect likely results from improved global arginine bioavailability and protection from hypertension-associated renal damage.
The high degree of between-study heterogeneity and the low number of available studies underline the need for further methodologically adequate analyses to confirm this evidence.
The high-dose dexamethasone did not suppress the elevated ACTH and cortisol.
The high education level included junior high school to senior high school and above college.
The high energy visible light between @number@ nm and @number@ nm ( blue light ) is incriminated.
The higher cerebral glucose metabolism in this brain region was positively associated with improved verbal memory seen in the combined group only.
The higher concentration in familial PD suggests that the mechanism may involve genetic factors.
The higher density MLBs occurred preferentially in older and more advanced cataracts suggesting a maturation process.
The higher distress reported by abstainers in this age group was partially explained by abstainers having poorer social relationships than light / moderate drinkers.
The higher DNA replication rate could not be attributed to mitochondrial DNA and may be due to satellite cell activation.
The higher-expressing mice displayed hyperactivity , memory deficits in the water maze and alterations in the round beam.
The higher frequency of bleeding was explained by concomitant antiplatelet treatments , and major asthenia was frequent in PS1 elderly patients.
The higher histological grade were correlated with pCR statistically ( Z = @number@ P = @number@ ) .
The higher incidence of AD among women indicates that sex is one of the main risk factor for developing the disease.
The higher incidence of LOAD can be explained by segregation of Alzheimer disease-related genes in these families or shared environmental risks.
The higher mortality rate in older individuals is a result of these pathologies.
The higher predictive power of oral word reading on cognitive scores compared to education was consistent across the three communities.
The higher prevalence of MCI in men may suggest that women transition from normal cognition directly to dementia at a later age but more abruptly.
The higher prevalence on geriatric wards could partly be explained by age-related changes in the regulation of serum sodium.
The higher rate of progression in MMAS may be due in part to the shorter follow-up time ( ∼3 years ) in MALES.
The higher rates of musculoskeletal injury among older workers may stem from a complex interaction of manual handling risk factors.
The higher resistance due to erupted second molars can be compensated by the use of higher forces without significantly reducing distalization speed.
The higher the age of the patient , the higher is the exposure to paracetamol.
The higher the owner in extraversion , the higher was the number of non-overlapping patterns per minute.
The higher value is reflective of Calgary's younger population compared to the rest of Canada.
The highest absolute FI value was @number@ in men and @number@ in women.
The highest accuracy was achieved based on objective cognitive impairment alone.
The highest age-specific prevalence rates were recorded among subjects ≥85 years old ( 100 / 100 ) .
The highest average number of cells was obtained by tissue homogenization and culture growth on the AmnioGrow medium.
The highest bond strength for both cements was achieved at @number@ hours , whereas the lowest bond strength values were recorded in the immediate groups.
The highest brominated , the decabromodiphenyl ether ( BDE-209 ) remains in use and its adverse and persistent effects are subject to debate.
The highest cfPWV and EVA values were observed in patients with diabetic nephropathy.
The highest concurrent fluctuations in CMRgl were basically identified between homologous cortical regions in all groups.
The highest correlations were between the SKT attention score and the WAIS-IV subtests for processing speed , perceptual reasoning and working memory.
The highest correlation was between delta bandpower increase and decline in the Rey Auditory-Verbal Learning Test ( @number@.59 : p < @number@ ) .
The highest erythrocyte membrane rigidity was detected immediately after strenuous exercise until exhaustion was performed.
The highest feasibility score was given to standard @number@
The highest feasibility values were given to standards @number@ @number@ and @number@
The highest GRS category identifies AMD patients with a sensitivity of @percent@ and a specificity of @percent@ when compared to the four lower categories.
The highest hip fracture rates were found in Scandinavia and the lowest in Africa.
The highest iLA was found in the obese hypertensive subgroup ( @number@ ml / m ; p < @number@ vs. all other groups ) .
The highest incidence occurs in the 65 + year age group , with males more than twice as likely to be afflicted as females.
The highest incidence of SNs was found in discs with degeneration grades III ( @percent@ ) and IV ( @percent@ ) .
The highest incidence of TBI occurs in young adults ( 15-24 years age ) and in the elderly ( ≥75 years of age ) .
The highest incidences of SNs presentation was on disks with degeneration grade III ( @percent@ ) and grade IV ( @percent@ ) .
The highest incidence was observed at ages of 70-79 years for thyroid cancer with tracheal invasion and 60-69 years for thyroid cancer without invasion.
The highest increments in lower and upper body strength were observed in the PrG ( @percent@ ) and ExG ( @percent@ ) , respectively.
The highest level of evidence was utilised by the committee to make evidence based recommendations based upon the Oxford grading system.
The highest microtensile bond strength was obtained for self-adhesive resin cements , with no significant difference between them.
The highest mortality was among men with 3MS < 78 , with @percent@ dying within @number@ months.
The highest positive correlation with change in restless sleep reports occurred with respect to health deterioration.
The highest prevalence of A and C clusters and obsessive-compulsive personality disorder was observed.
The highest prevalence of home healthcare services was in the 75-84 year age group in both sexes.
The highest prevalence rates of delusions were found through the CUSPAD , and the lowest through the CERAD-BRSD.
The highest prevalence values were estimated for breast and colorectal cancer with about @number@ and over @number@ cases in @number@ respectively.
The highest proliferative activity and maximal thickness of the epidermis were detected at the age of 19-21 years.
The highest quantitative synovial hypertrophy values were found in the hip ( @number@ mm ) and talonavicular joint ( @number@ mm ) .
The highest-ranked dynamic exercise for all muscle segments was the dip test.
The highest rate of polysensitization ( @percent@ ) was found in participants with comorbid asthma and allergic rhinitis.
The highest rate of vaccine coverage ( @percent@ ) occurred two years after the pandemic.
The highest rates are seen among the elderly , second only to hip fractures.
The highest rates of regional GM loss were found in the frontal and parietal cortices , middle occipital gyri , temporal cortex and hippocampus.
The highest response rate was observed at day @number@ ( @percent@ ) .
The high estrogen group ( luteal ) had an overall greater strength decrement and higher CK concentration at @number@ hours.
The highest rTL variability was observed in peripheral leukocytes , and the lowest variability was found in brain.
The highest sample frequencies and conversion rates were associated with case definitions of multiple-domain MCI.
The highest tertile of energy intake was associated with lower depression incidence after controlling for all confounders ( OR @number@ 95%CI @number@.34-0.87 ) .
The highest tooth shade prevalence belonged to the second group and the highest skin colour prevalence was also in the second skin colour group.
The highest total color difference ΔE ab was found in the Red Bull group after @number@ days.
The highest values of spherical refractive error were observed in WTR astigmatism group.
The high evolutionary rate was partly due to relaxation of some selection pressures and partly to distinct positive selection of SOD1 in great apes.
The high expulsion group had the least regression , based on the Sundbärg index.
The high-frequency condition triggered lower mirror-movement ratios.
The high image contrast and noninvasive properties make OCM ideal for performing longitudinal studies without requiring tissue dissections or staining.
The high incidence of CAP poses a significant health and economic burden in this region.
The high incidence of cervical cancer is a consequence of the inability of most countries to either initiate or sustain cervical cancer prevention services.
The high-intensity telemedicine model of care has been proposed as an innovative approach to expand access to acute illness care , thereby preventing ED visits.
The high level of psychological distress found corroborated previous studies.
The highly complex structure of the human brain is strongly shaped by genetic influences.
The highly vulnerable CA1 pyramidal neurons were characterized by age- and disease-unrelated increases in PRCKB levels and by age- and disease-related increases in MAPK1 levels.
The high mortality in hip fracture patients remains a challenge both in middle-aged and elderly individuals.
The high odds of physical limitations in non-drinkers can be largely explained by poor health of former drinkers.
The high prevalence of childhood trauma among aging prison inmates warrants attention to increasing social support mechanisms to improve mental health.
The high prevalence of chronic HCV infection has led to an increased risk for liver failure and hepatocellular carcinoma.
The high prevalence of IgE binding to the Der f 14-N indicates that it could be an important mite allergen.
The high prevalence of stunting indicates the need to perform preventive nutritional intervention beginning earlier in life , i.e. , in utero.
The high prevalence of this condition and multiple etiology factors makes of its treatment a challenge-especially in the older population.
The high prevalence of this pathogen found in ocular samples should alert ophthalmologists to focus on the role of C. trachomatis in adult conjunctivitis.
The high prevalence of this subset of hand OA is a concern in an aging population.
The high price for organic meats was the strongest limiting factor for organic meat purchases followed by poor availability.
The high protein expression of Rab1B and MMP9 in @number@ CRC tissues is associated with deep tumor invasion , lymph-node metastasis and advanced TNM stage.
The high rates of osteopenia and osteoporosis in SCD support the need for research addressing this rising public health problem.
The high response rates observed after @number@ months suggest a good effectiveness beyond this observation period.
The high risk of stroke in elderly patients with atrial fibrillation is markedly reduced with warfarin , although bleeding risk is increased.
The high-risk participants were recognized according to the National Diabetes Prevention and Control Committee criteria and were introduced to an assigned laboratory.
The high-risk subjects were significantly heavier , had greater waist and hip circumferences , higher AHI , and reported more frequently hypertension and diabetes.
The high scores of BBS-9 were associated with better static and dynamic balance.
The high sensitivity and specificity of MNA-SF might be sufficient for medical practice to identify patients at undernutrition risk or undernutrition.
The high specificity is due to the broad exclusion criteria.
The high test-retest ICC and the low CV and TEM values confirmed the reliability of all anthropometric measurements in young artistic gymnasts.
The high VO2 max of Tsimane is consistent with their high physical activity and few indicators of cardiovascular disease , measured in previous studies.
The HILAQ strategy simplifies the analysis of newly synthesized proteomes through the use of isobaric labels and achieves higher sensitivity than previously published methods.
The hip arthropathy which occurs in Hereditary Haemochromatosis ( HH ) and the ostensibly idiopathic precocious bilateral concentric form of hip OA are virtually indistinguishable.
The hip axis ( HA ) was @number@ cm anterior to the GL.
The hippocampal lesions were moderately argyrophilic and Thioflavin-S negative.
The hippocampal neurovascular niche and the total number of microvessels are also changed after radiation exposures.
The hippocampal volume was quantified from a three-dimensional T1-weighted MRI using semi-automated software.
The hippocampus and thalamus assume a significant role in the overnight consolidation of memories , a process that is negatively impacted by sleep disruption.
The hippocampus demonstrated similar patterns across the groups , showing task-induced activity that decreased in response to repetition.
The hippocampus displayed a series of synergistic biochemical alterations , including microgliosis , deposition of Aβ precursor protein fragments , and cellular degeneration.
The hippocampus is a crucial player across several learning and memory domains , and is highly vulnerable to alterations during aging.
The hippocampus is a primary region of neurogenesis within the adult mammalian brain.
The hippocampus is a structure equipped with a high degree of flexibility and adaptation.
The hippocampus is composed of distinct subfields : the four cornu ammonis areas ( CA1-CA4 ) , dentate gyrus ( DG ) , and subiculum.
The hippocampus is crucial for long-term episodic memory and learning.
The hippocampus is deteriorated in various pathologies such as Alzheimer's disease ( AD ) and such deterioration has been linked to memory impairment.
The hippocampus is vulnerable to age-related changes ranging from gene expression to network connectivity.
The hippocampus shows a selective vulnerability under several noxes especially those including hypoxia.
The hippocampus shrinks in late adulthood , leading to impaired memory and increased risk for dementia.
The hippocampus was manually segmented in each hemisphere , and volumes were calculated with correction for intracranial volume.
The hippocampus was segmented using an automated method.
The Hippo pathway plays an evolutionarily conserved fundamental role in controlling organ size in multicellular organisms.
The Hippo pathway was initially identified in Drosophila by genetic mosaic screens for tumor suppressor genes.
The Hippo signaling pathway is regulated by various stimuli , such as mechanical stress , G-protein coupled receptor signaling , and cellular energy status.
The hiPS-RPE could therefore be a very good candidate for RPE replacement therapy in AMD.
The HIS-Q-SF is an abbreviated version including17 items from the original 28-item HIS-Q.
The histogram plot showed @number@ clearly divided modes for GBM thickness.
The histological analysis result further demonstrates that ACPs exerted a stronger beneficial effect on normalizing skin structure and collagen arrangement than TP and CP.
The histological examination after neuro-surgery showed an atypical pituitary adenoma with FSH-positive cells.
The histological grade and the immunohistochemistry results of Ki67 and p53 are related to pCR of neoadjuvant chemotherapy for primary breast cancer.
The histological results revealed a progression of wound depth for different peeling agents without full thickness necrosis.
The histologic effects , efficacy , and treatment safety in various clinical conditions and for different phototypes are discussed.
The histone acetyltransferase ( HAT ) regulator of Ty1 transposition @number@ ( Rtt109 ) is the sole enzyme responsible for H3K56ac in yeast.
The histone deacetylase SIRT6 promotes DNA repair , but its activity declines with age with a concomitant accumulation of DNA damage.
The histopathologic appearance of gold threads is particularly distinctive and easily recognizable by dermatopathologists.
The histopathologic findings showed thickened collagen bundles.
The historical roots of gerontology date to a time when old age was characterized as physical and mental decline.
The historical underpinnings in the field of gerontology rest on the contributions of scholars across a myriad of racial and ethnic backgrounds.
The history of aspiration could be recalled after confirmed diagnosis for the other seven cases.
The history of chemotherapy for MM began in the early 1960s , when the efficacy of alkylating agents , particularly melphalan , was shown.
The history of studies on cultured cells is reviewed.
The HIV CONCLUSIONS : This cohort has high CMD risk based on both traditional risk factors and novel markers like hsCRP.
The HIV epidemic in the United States has affected at least two generations of gay men.
The HIV-infected population in the United States is aging.
The HIV-infected population is aging and comorbidities and polypharmacological regimens are increasing.
The HLA-humanized mice may thus represent valuable tools to test HLA-based vaccines and therapeutics for human autoimmune diseases.
The Hmox1 promoter contains numerous consensus sequences that render the gene exquisitely sensitive to induction by diverse pro-oxidant and inflammatory stimuli.
The Hochschild's method and KDM share a similar concept , making CA an independent variable.
The holoTC-AD relationship was less influenced by controlling for tHcy ( OR changed from @number@ to @number@ @percent@ CI @number@.968-1.000 ) .
The home-based step training program could therefore be included in exercise programs designed to prevent falls.
The home care cases were compiled by the university faculty members and the home care practice pharmacists.
The home care clinic group indicated a demand of the swallowing function test in short-term admission or home practice.
The home care worker plays a key role in ensuring the overall satisfaction in the caregiving triad.
The home-diet was assessed by means of @number@ non-consecutive 24-hr recalls.
The homeostasis model assessment insulin resistance ( HOMA ) was also measured.
The homeostasis model assessment of IR ( HOMA-IR ) was used to measure IR.
The homeostatic insulin resistance model was > 2.8 in @number@ ( @percent@ ) .
The homeostatic model of aging formalizing the concept of oxidative damage to the body was proposed in @number@
The homogenate is compared with the Pfi preparation.
The homozygotes were chosen because APOE ε3 / ε3 variant is considered \ "neutral \ " with respect to LOAD risk.
The Hong Kong Chinese version of the World Health Organization's Quality of Life-Brief version was used.
The Honolulu-Asia Aging Study began @number@ years later , with cognitive assessment by the Cognitive Abilities Screening Instrument ( CASI ) in @number@ men.
The hope is that with insightful preparation the older population can be spared then worse consequences of a disaster when it strikes.
The hormetic response involves the expression of genes that encode cytoprotective proteins such as chaperones like heat-shock proteins , antioxidant enzymes and growth factors.
The hormones used are estrogen and anti-androgen for MtoF and testosterone for FtoM persons.
The Hospice Palliative Care Act , amended on @date@ , legalizes the CE procedure in Taiwan.
The Hospital Anxiety and Depression Scale ( HADS ) was used to assess depression and anxiety.
The Hospital Anxiety and Depression Scale was used to assess anxiety and depression.
The hospital costs for these rehospitalizations was €52 millions.
The hospital is one of the premier hospitals covering the South East zone of Nigeria.
The hospital stay and the cost for the first surgical procedure did not show statistically significant differences between TPI and CLI.
The host-pathogen interaction is strikingly complex during HIV infection.
The hours per week of active help and supervision were ascertained by informant questionnaire.
The HOXB13 gene has been implicated in prostate cancer ( PrCa ) susceptibility.
The HPA AR may vary with age and gender.
The ( HPA ) axis has been evaluated in psychiatric diseases where hypercortisolism and oxidative stress are often present.
The HPLC fraction from the extract that was most protective against oxytosis contained the alkaloid voacamine ( MW = 704.90 ) as the predominant compound.
The HR data indicated a moderate cardiac stress level throughout the shifts , despite which WP decreased after @time@ .
The H-reflex is dependently modulated during isometric and anisometric muscle actions.
The HR for total and ischemic stroke for calcium intake also showed a borderline trend ( p = 0.071 and @number@ respectively ) .
The HR group had higher preoperative albumin level than did the non-HR group.
The HRindex and interocular differences could be used to screen for and separate the earliest stages of subclinical disease from changes caused by normal aging.
The HR NBL survivors had significantly shorter telomere length and higher serum levels of high sensitivity C-reactive protein than did the controls.
The HRS CAMS includes information on types and amounts of activities.
The HRs estimated from the competing risk models remained unchanged.
The HRS has expanded its economic measurement to longitudinal studies of consumption and to broader-based measurement of pension and Social Security wealth.
The HR was not significant for @number@ participants with low-risk WCH and age-matched low-risk normotensive subjects.
The HS-Aging pathology protective ABCC9 haplotype was associated with decreased ABCC9 expression , indicating a possible toxic gain of function.
The hs-CRP level in the population studied was @number@ + / - @number@ mg x L ( @number@ ) . hs-CRP significantly increased with age.
The HSF processing deficit could be partially restored by enhancing luminance contrast.
The Hsp90 and p23 molecular chaperones have been shown to associate with hTERT for the assembly of active telomerase.
The HUCB cell preparation is composed of immature T-cells , B-cells , monocytes and stem cells.
The HUGE equation has been recently described and validated in Spain for screening CKD without taking into account the patient's GFR value.
The human aging process is often accompanied by significant increases in degenerative spine disease.
The human APE1 has recently been shown to endonucleolytically cleave single-stranded regions of RNA.
The human auditory brainstem is thought to undergo rapid developmental changes early in life until age ∼2 followed by prolonged stability until aging-related changes emerge.
The human body is naturally selected to be well-functioning until the age of reproduction to keep the species alive.
The human brain comprises distributed cortical regions that are structurally and functionally connected into a network that is known as the human connectome.
The human brain contains an intricate network of about @number@ billion neurons.
The human brain displays oxidant and antioxidant markers with regional specificity that directly impinges on neuronal function in aging and in disease states.
The human brain expresses three additional isoforms with three microtubule-binding repeats ( 3R ) each.
The human brain is a complex network.
The human brain is a complex network that is known to be affected by normal aging.
The human brain is a complex system whose topological organization can be represented using connectomics.
The human brain presents multiple asymmetries that dynamically change throughout life.
The human CCAAT / enhancer-binding protein ( CEBP ) delta ( CEBPD ) is known to be induced in many inflammation-related diseases.
The human circadian clock ensures that biochemical and physiological processes occur at the optimal time of day.
The human cytomegalovirus ( CMV ) has increasingly been implicated in accelerated immunosenescence in aging studies.
The human environment is subjected to changes due to anthropogenic activity.
The human eye is constantly exposed to sunlight and artificial lighting.
The human eye is enriched in MTs , and multiple isoforms may contribute to distinct antioxidant defense mechanisms in various ocular tissues.
The human gastrointestinal microbiota plays a key homeostatic role in normal functioning of physiologic processes commonly undermined by aging.
The human genome comprises of many protein coding and even more non-coding RNA genes.
The human genome encodes seven different sirtuins ( SIRT1-7 ) , which share a common catalytic core domain but possess distinct N- and C-terminal extensions.
The human gut contains trillions of microbes which form an essential part of the complex ecosystem of the host.
The human hip is subjected to several hundred million loading cycles during a lifetime.
The human immunodeficiency virus ( HIV ) and acquired immunodeficiency syndrome ( AIDS ) pandemic has entered its 4th decade.
The human intestine is colonised by 10¹³ to 10¹⁴ micro-organisms , the vast majority of which belong to the phyla Firmicutes and Bacteroidetes.
The human jaw system is different from those of other primates , carnivores , ruminants , and rodents in temporomandibular joint and muscle anatomy.
The human lens contains three major protein families : α- , β- , and γ-crystallin.
The human lens , which contains proteins that do not turnover , is used to illustrate the impact of these gradual deleterious modifications.
The human monoclonal antibody against RANK-L ( denosumab ) has been approved for the treatment of osteoporosis.
The human MPV17-related mitochondrial DNA depletion syndrome is an inherited autosomal recessive disease caused by mutations in the inner mitochondrial membrane protein MPV17.
The human organism has developed a protection system against the destructive action of free radicals by means of the antioxidant network.
The human population is getting older , and technology will play a key role in addressing the pressures this aging will place on healthcare systems.
The human preterm brain is particularly susceptible to cerebral white matter injury ( WMI ) that disrupts the normal progression of developmental myelination.
The Human Rights treaty bodies rank the elderly as a vulnerable group , who are more susceptible to various forms of discrimination.
The human skeleton optimizes its microarchitecture by elaborate adaptations to mechanical loading during development and growth.
The Hutchinson-Gilford progeria syndrome ( HGPS ) is an exceptionally rare medical disorder caused by mutations in the lamin A / C gene.
The HVa was lower in men than in women overall ( P < @number@ ) and more specifically beyond age @number@ years.
The HVa worsened gradually from age @number@ years to the mid-60s and more steeply beyond that age.
The hybrid layer formed in intertubular old dentin ( G15O ) was very thin.
The hybrid materials comprised biological tissue grown on the fabric.
The hybrid material showed a comparable performance to conventional filters for protein removal.
The hybrid material showed lesser blood coagulation than polysulfone and cellulose.
The HYDI diffusion-encoding scheme consisted of five concentric q-space shells with b values ranging from @number@ to @number@ s / mm ( @number@ ) .
The hydrophilic and acidic characteristics of current dentin adhesives have made hybrid layers highly prone to water sorption.
The hydrophilicity of the dentin matrix during and after bonding procedures may result in an adhesive interface that is more prone to degradation over time.
The hyoid and laryngeal elevation allows the bolus to enter the esophagus.
The hyperactivity subgroup was associated with combination use of memantine and AChEI.
The hyper-elastic behaviour of the human sternocleidomastoideus muscle has been previously studied.
The hyperintensities appeared most frequently in the deep white matter of the frontal lobe with a similar average hyperintensity size in all hemispheric lobes.
The hyper-phosphorylated tau-mediated intracellular neurofibrillary tangle and amyloid β-mediated extracellular senile plaque are characterized as major pathological lesions of AD.
The hyperplastic endometrium of both postmenopausal women and aged mice exhibited elevated mTOR activity as seen with increased expression of the pS6 protein.
The HyperSPHARM coefficients are global ; they cannot be used to directly infer localized variations in signal.
The hypertrophic response to resistance training is generally attenuated with aging ; yet the mechanisms regulating this phenomenon are largely unknown.
The hypometabolism patterns in several areas of the brain were significantly correlated with the clinical manifestations.
The hypoperfusion leads to activation and degeneration of astrocytes with the resulting fibrosis of the extracellular matrix ( ECM ) .
The hypothalamus is likely to play a major role in the regulation sleep , metabolism , and their interaction.
The hypothesis could lead to developing new treatments for age-related illnesses and help humans to live longer.
The hypothesis is advanced that cortical changes in the course of aging might differentially impact on tDCS efficacy on behavioral performance.
The hypothesis is that ageing and / or the increased age-related burden of pathology explains the declining SRH.
The hypothesis that faster age-related reduction in testosterone is linked with increased PCa risk remains untested.
The hypothesis that presbycusis and presbystasis have a genetic background was proposed some years ago.
The hypothesis that the relationship of perceived social support and social networks to SRH differs according to gender has been confirmed.
The hypothesis that we present provides new bases for modern medical problems , such as inflammation-induced neoplasia and degenerative diseases of the elderly.
The hypothesis that β-blockers cause depression has been both confirmed and refuted in previous studies.
The hypothesis was tested using structural equation modeling.
The hypothesis was that mineral bone density of the coracoid process decreases with age.
The hypothesis was that older adults attempt to compensate for sensory and motor slowing by using progressively larger perceptual units ( holistic encoding ) .
The hypothesis was that the auto-polymerizing cements would show less color and opacity stability.
The hypothesis was that the visual cues would help PD and NC to exert better control over bistable perception.
The hypothesized positivity ratio group × time interaction emerged for each psychological health measure.
The hypothesized SEM model was supported with adequate fit ( χ OBJECTIVES : To investigate the relationship between vision and disability in the elderly.
The hypothetical inverse association between MPOD and ARM stage was not confirmed.
The hypothetical involvement of the age-related gut microbiota unbalances in the inflamm-aging , and immunosenescence processes will also be discussed.
The hypothetical role of several other factors remains to be clarified.
The hypoxia-induced upregulation of HOTAIR expression may contribute to its roles in tumorigenesis.
The hypoxia inducible transcription factor HIF1 activates autophagy , a general catabolic pathway involved in the maintenance of cellular homeostasis.
The HZ vaccine was approved by the US Food and Drug Administration for individuals aged 50-years or older.
The IADL Hierarchy Scale consisted of @number@ items , meal preparation , housework , shopping , finances and medications.
The IAServ is expected to offer intelligent , pervasive , accurate and contextually-aware personal care services.
The iatrogenic deformity and reoperation rates were both less than @percent@.
The IBI was associated with cognitive decline in the memory domain , adjusting for demographic and vascular risk factors ( P = @number@ ) .
The ICA was an average @number@ mm from the midline ( minimum @number@ mm ) .
The ICC for the interrater reliability was @number@ ( P < @number@ ) .
The ICC for the total score was @number@ ( @percent@ CI @number@.61-0.89 ) .
The ICC method also demonstrate its strength as a useful tool to reorganize care.
The ICC results of VE showed poor reliability for hip and knee joints.
The ICC values of the @number@.5- and @number@.0-kg SMBT were R = @number@ and @number@ respectively.
The ICER was $ 1 , 754 per LYG in France and $ 32 , 415 per LYG in the United States.
The ICF underlines the multifaceted and complex nature of functioning in which disease , environmental factors , and personal factors play a role.
The ICH occurred in a patient taking VKA.
The ICI ratio at ISI of @number@ ms was decreased in RLS patients only.
The ICRP @number@ updated tissue-weighting factors decrease the effective dose in most cases.
The ICRs from C3 / C4 to C6 / C7 were determined from the radiographs using MIMICS software.
The ICS prescription rate before and after guideline dissemination was @percent@ and @percent@ respectively ( P < @number@ ) .
The ICSS is a feasible approach for supporting caregivers who prefer an alternative service model.
The ICTs in homes can now help prolonge our longevity.
The I-DAS had a three-factor structure , such as the original scale.
The I-DAS scored was significantly correlated with individuals ' education , but not with age or gender.
The I-DAS showed good psychometric properties and can be a valid and reliable tool to assess multidimensional apathy.
The I-DAS showed high internal consistency , good convergent and divergent validity.
The idea has been changing with regards to the extracranial venous system.
The ideal anti-OA drug should have immunomodulatory effects while at the same time having limited or no toxicity.
The ideal interval ( s ) during which a delirium screening process should take place has yet to be determined.
The idealization of classes , both theoretical and practical , proposed in this work proved to be of great value in teaching physicians.
The ideal study would combine field and laboratory observations and experiments.
The ideal treatment of the nasolabial fold , the tear trough , the labiomandibular fold and the mentolabial sulcus is still discussed controversially.
The idea was to first experiment with innovative long-term care practices outside the system and then to scale-up these innovations to change the system.
The identification and control of modifiable risk factors could influence conversion to dementia.
The identification criteria for AKI included the @number@ KDIGO AKI definition and an expanded criterion.
The identification of ALS biomarkers in presymptomatic individuals might also provide clues to the earliest biochemical correlates of the disease.
The identification of cost-effective interventions that improve the health status and prevent disability in old age is one of the most important public health challenges.
The identification of different patient profiles can help defining the best care strategy according to specific patient needs.
The identification of different subtypes of DRPs and the factors associated with DRPs may facilitate risk reduction for BPH patients.
The identification of disease-causing mutations in Alzheimer's disease has contributed greatly to the understanding of the pathogenesis of this disease.
The identification of dividing myocytes in the adult and senescent heart raises the important question concerning the origin of these newly formed cells.
The identification of early cellular mechanisms in the advent of obesity- and diabetes-related renal complications could afford avenues for future therapeutic interventions.
The identification of functional targets represents a major hurdle in our understanding of microRNA function in ovarian carcinoma , but significant progress is being made.
The identification of gene-diet associations is likely to provide useful information about the etiology of postmenopausal dyslipidemia and help in effective treatment.
The identification of geriatric syndromes might help to improve comprehensive care for community-dwelling older adults.
The identification of health factors that influence physical activity level ( PAL ) will help in the development of strategies for increasing PAL older adults.
The identification of LOAD risk loci associated with non-clinical cognitive performance may help in screening for individuals at greater risk of cognitive decline.
The identification of longevity-related structural adaptations in biological macromolecules may yield relevant insights into the molecular mechanisms of aging.
The identification of miRNA-mRNA networks that modulate the health and functionality of lin- BMCs is a critical step in understanding the process of vascular repair.
The identification of molecular changes that take place during skin aging provides biomarkers and possible targets for therapeutic intervention.
The identification of new drugs that provide benefit in arresting the decline seen in PD patients is the focus of much recent study.
The identification of novel anti-apoptotic sequences has lead to new insights into the mechanisms involved in regulating different forms of programmed cell death.
The identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major paradigm shift in the field.
The identification of presarcopenia has important implications for dietary interventions that might delay age-associated loss of lean mass.
The identification of regulatory elements in the promoter of RACK1 shed some light on its transcriptional modulation in physiological and pathological context.
The identification of reliable diagnostic biomarkers in differential diagnosis of neurodegenerative diseases is an ongoing topic.
The identification of retinoids cellular receptors was reported in @number@ but a direct cause-effect relation has not been established.
The identification of risk factors for accelerated MQ decline may offer clues to identity the underpinning physiological mechanisms and indicate targets for prevention and treatment.
The identification of safe gaps between passing cars when crossing a street is a task most of us accomplish successfully on a daily basis.
The identification of sleep disturbances may help identify high-risk Chinese elders who may benefit from fall prevention education.
The identification of specific membrane receptors that bind and internalize extracellular ligands has revolutionized the traditional roles of this tissue.
The identification of these factors may provide insight into which patients would benefit most from aggressive surgery.
The identification of these mechanisms has been facilitated by pharmacological studies and has opened new possibilities for pharmacotherapeutic approaches to the treatment of brain disorders.
The identification of which chronic diseases contribute most to the disability prevalence is important to reduce the burden.
The identification was carried out by biotin pull-down assays followed by LC-MALDI TOF / TOF mass spectrometry.
The identified associations will need to be followed up in further studies.
The identified CpG sites could potentially be prognostic epigenetic markers of OS and OS-related health outcomes.
The identified CpG sites have the potential to be prognostic biomarkers of frailty and frailty-related health outcomes.
The identified genes include splicing factors , vacuolar sorting proteins , transcription factors , and metabolic enzymes.
The identified GPHN microdeletions involve exons 5-9 ( Δ5-9 ) and 2-3 ( Δ2-3 ) , both affecting the gephyrin G-domain.
The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes.
The identified proteins interacting with the FRA16D fragment included some known CFS stabilizers , thereby validating this screening approach.
The identities of the enzymes responsible for these activities in whole blood of neonates have been defined in this study and contrasted to adult blood.
The identity of prohibitin in the retina and RPE was studied using 2D electrophoresis , immunohistochemistry , western blot , and mass spectrometry analysis.
The identity of selenoproteome of Msrs will be sought along with characterization of the identified selenoprotein forms.
The IDS group showed wider cognitive decline in tests of short-term verbal memory and category verbal fluency compared to the NDS group.
The IDS-TILDA consists of a random sample of @number@ persons aged @number@ and older.
The IDTS Advisory Committee meets annually to review these data and monitor trends.
The IFD rate appears higher than previously reported , warranting further investigation.
The IgE-binding capacities of the PCI- and sham-treated HDM allergens were analyzed by an ELISA.
The IGF1 / IGFBP3 ratio was also calculated.
The IgG1 responses in the INF were high regardless of age.
The IG showed increased levels of PA at post-intervention and 6-month follow-up.
The IGT group also oxidized less carbohydrate during insulin infusion than NGT ( P < @number@ ) .
The IHC test demonstrated excellent performance at a level equivalent to two DNA-based counterparts ( pyrosequencing and SNaPshot ) .
The IL-17 and STAT3-expressing CD4 ( + ) splenocytes dramatically decreased in the rhIL-21R-Fc treated mice.
The IL-2-stimulated NK cell assay had improved specificity , but @number@ out of the @number@ non-FHL3 patients still showed degranulation below the threshold level.
The IL-6 gene polymorphism has been associated with disease prevalence and different physiological responses to exercise.
The IL-8 response to the shifts may also increase with age.
The ILB was not associated with measures of eyelid height such as palpebral fissure width.
The IlluminOss™ monomer offers ease of control for use in biological tissues.
The illustrative case example used in this paper emerged from a larger critical ethnographic study of aging in the Filipino community in Montreal , Canada.
The Image of Aging Scale and Likert-style questions to measure interest in working with older adults were the primary outcome measures.
The image quality index was given by the OCT software.
The images of the PCoA in @number@ fetuses were also reviewed.
The images were assessed subjectively for gray and white matter relative signal intensity and results correlated with histologic findings.
The images were then analyzed with 3DSTE software.
The imaging was repeated five times for averaging.
The imbalance of any signals involved in this process may result in either premature aging or tumorigenesis and reduce the life span of the organism.
The IMCL content was ~2-fold higher at baseline and 12h post-exercise in old compared with young individuals.
The immaturity of neurons differentiated from human induced pluripotent stem cells ( hiPSCs ) presents difficulties for modeling late-onset neurodegenerative disorders such as Parkinson's disease.
The immediate post-treatment histological evaluations showed architectural disarray of dermal collagen and elastin.
The immigrants work and live in garment sweatshops and speak their original languages.
The immune response analysis identified several relevant modules , consistent with recent findings on apoptosis and NFκB activation following infection.
The immune response is essential for keeping an organism healthy and for defending it from different types of pathogens.
The immune system and β cells undergo senescence and this impacts on the risk for developing post-transplant diabetes and our ability to prevent such development.
The immune system dysfunction seems to be somehow mitigated in this population , probably due to genetic and environmental factors yet to be described.
The immune system is a critical component in defense against viral , bacterial , parasitic , and fungal diseases.
The immune system is affected by the aging process and undergoes significant age-related changes , termed immunosenescence.
The immune system is intimately involved in the pathophysiology of several human disorders.
The immune system is the result of the interplay between innate and adaptive immunity , yet the impact of aging on this function is unclear.
The immune system protects organisms against environmental and endogenous pathogens.
The immune systems of men and women differ in significant ways , especially after puberty.
The immune system undergoes a complex and continuous remodeling with aging.
The immunized mice additionally showed improvements in two behavioral assays , odor habituation and nesting behavior.
The immunoblotting profiling verified the role of proliferation in skin damage induced by osthole , byakangelicin , and 7-hydroxycoumarin.
The immunoexpression of elastin decreased in the elderly larynges , in both lamina propria layers of the vocal folds.
The immunofluorescence assay showed aspirin could prevent the nuclear translocation of GLI1 to inhibit its transcriptional regulation.
The immunohistochemical findings corresponded to type A of the FTLD-TDP pathology classification system.
The immunohistochemical method with anti-human CD34 was used for the detection of the capillary endothelium.
The immunohistochemistry profiles of small-cell carcinoma of the esophagus and the lung are highly similar.
The immunostaining for Klotho was mostly localized in the cytoplasm.
The impact is more substantial in analyzing macular progression than circumpapillary RNFL progression.
The impact of adult bone traits on changes in bone structure and mass during aging is not well understood.
The impact of aging and physical capacity on coenzyme Q10 ( Q10 ) levels in human blood is unknown.
The impact of aging on audio-visual integration also depended on the quality of the visual cues.
The impact of aging on t-m transformation and micro crack formation was measured.
The impact of a high-cholesterol diet was assessed by measuring the serum cholesterol level and the infarction volume was determined by magnetic resonance imaging.
The impact of an age-dependent decline of stem cell function weighs differently in organs with high or low rates of cell turnover.
The impact of aortic stiffness on cardiovascular outcomes is proposed to be mediated by the attenuation or the reversal of the arterial stiffness gradient.
The impact of a pop out distracter and a dual task on the FFOV measure was also investigated.
The impact of catch-up growth on adult lung function and the relationship between childhood BMI trends and adult lung function were assessed using regression analyses.
The impact of cognitive task complexity on walking also was examined.
The impact of dietary factors on brain health and vulnerability to disease is increasingly appreciated.
The impact of dietary habits on our health is indisputable.
The impact of gender was also assessed.
The impact of generosity on residents ' medication use and health outcomes is unknown.
The impact of GNEC is discussed along with effects on faculty participants over @number@ years.
The impact of HAART on ICU outcomes is unclear.
The impact of healthy mid-life ageing on these processes has not been characterised.
The impact of hearing impairment is as detrimental for young and middle-aged as it is for older adults.
The impact of HSP72 on β-cell metabolic status was determined using Seahorse Bioscience XFe96 technology.
The impact of intrinsic aging upon human peripheral blood T cell subsets remains incompletely quantified and understood.
The impact of long-term stress on depressive status ( evaluated with CES-D10 , score range 0-30 ) was determined with multivariate logistic regression analysis.
The impact of low Cd levels on kidney function and gender differences in Cd levels needs further investigation.
The impact of medical tourism on CRC screening is unknown.
The impact of MetS on arterial function was similar in men and women.
The impact of MPA on the vasculature of older adults remains unclear.
The impact of multimorbidity on disability in each activity was substantial , while education was not.
The impact of mutations on cell-cycle advancement was assessed by flow-cytometry.
The impact of mutations on HBsAg-secretion was assessed by measuring the ratio [ secreted / intracellular HBsAg ] until day @number@ post-transfection.
The impact of NCLEX-RN failure is felt not only by the graduate student and their nursing program , but by healthcare organizations as well.
The impact of NO availability on development of LVH has never been demonstrated in humans.
The impact of obesity on HR-QOL is particularly strong in young people , who are free of co-morbidities.
The impact of Parkinson's disease on quality of life may vary depending on age at onset.
The impact of pharmaceutical care on non-adherence and hospitalisation was analysed by @number@ × @number@ tables , and mortality by Cox regression.
The impact of physical function impairments on health-related quality of life ( QoL ) during ART is unknown.
The impact of poor appetite on food intake in older adults is unknown.
The impact of race was tested using a race interaction term.
The impact of resistance exercise alone on CV risk markers in type @number@ diabetes remains unclear.
The impact of rs2229901 on GRM4 / miR-1202 hybrid stability and local GRM4-3 ' UTR secondary structure were assessed using RNAsnp program.
The impact of sepsis-related deaths on all-cause hospital mortality is insufficiently described , in particular in Europe where data are non-existent.
The impact of sex , education level , and APOE genotype on cognitive trajectories was assessed.
The impact of such memory systems on lung regeneration is currently unknown.
The impact of the flow rate , the compliance chamber volume and mixing were investigated.
The impact of the immunosenescence process varies amongst the different cellular subsets represented within the immune system.
The impact of the pathology on ageing immunity is poorly understood and few data are available on the immunological status of old polypathological patients.
The impact of the program upon older listeners ' mood , quality of life ( QOL ) and self-reported loneliness was independently evaluated.
The impact of these care models on the quality of life of residents has been studied.
The impact of these demographic changes over the activity in the gynecology-obstetrics field is not clearly identified.
The impact of these SNPs , which may exert joint effects , may be obscured by gene-environment interactions or inter-ethnic differences.
The impact of the various barrier functions on successful viral invasion is not known.
The impact of this evolutionarily conserved pathway on the modulation of human lifespan remains unclear.
The impact of type @number@ diabetes on ageing societies is great and populations across the globe are becoming more diverse.
The impact of varicocele detection and surgical correction on sperm parameters / fatherhood is debated.
The impact of vascular burden on the association did not differ between younger and older adults.
The impact on cardiac outcomes remains unclear.
The impact on the food industry will be specific to each company based on their products , culture and capacity to adapt.
The impact on the subjective perception of cognitive decline has not yet been examined.
The impacts of allotment gardening on health and well-being were moderated by age.
The IMPACT team met with Mr K and his wife for a @number@ h interprofessional assessment.
The impact was greatest for both continued workforce participation and need for assistance for those suffering from depression or anxiety.
The impaired recovery from fatigue in older adults relied more on the recovery of central factors.
The impaired suppression of reflexive saccades may be explained if the excessive inhibition of SC is \ "leaky. \ "
The impairment in specific cognitive functions ( i.e. memory and executive functions ) seems to correlate with the decline in the most complex mentalistic abilities.
The impairment of humoral immune response in elderly humans has been extensively demonstrated.
The impairment of memory functions in T-pos seniors was accompanied by a decreased self-reported quality of life.
The impairment of primary haemostasis induced by SSRIs may result , as a beneficial counterpart , in a reduction in the thrombotic risk.
The impairment of this system underlies POAG-associated pathogenesis , supporting the possibility that Tie2 agonists could be a therapeutic option for glaucoma.
The impairments mostly began after age @number@ and increased with age particularly at ages 85 + .
The impetus in initiating and continuing this work requires a \ "knowledge of our roots \ " while moving into the future.
The implementation is described using the Fixsen and Blasé implementation process model.
The implementation of high-quality , evidence-based perioperative care programs for the elderly on an ambulatory basis has assumed increased importance.
The implementation of this tool into preclinical frailty research should greatly accelerate translational research in this important field.
The implemented sodium-reduction strategies were product substitutions , recipe modifications , and cooking from scratch.
The implicated genes are expressed in the developmental and adult human brain.
The implication of ANRIL in cellular aging has provided an attractive unifying hypothesis to explain its association with various susceptibility risk factors.
The implication of these observations is that the medical education enterprise urgently needs an international initiative of faculty development around CBME and assessment.
The implication of this gene is further supported by association with the endophenotype biomarker results.
The implications and future directions for gerontological social work , research , and policy with older adults in the criminal justice system are advanced.
The implications for future research reach across several fields of study and application.
The implications for national inpatient capacity requirements have not been quantified.
The implications for nursing care of critically ill elders who have these conditions are also discussed.
The implications for policy and practice are outlined.
The implications for social work practice are discussed.
The implications for the development of genetic or pharmaceutical interventions for the treatment of mitochondrial malfunction in complex disease are also explored.
The implications of activity for self- and social-identity in PWD and caregiver are discussed.
The implications of results are discussed in terms of behavioral adaptation and safety.
The implications of these findings are discussed in the light of classic and recent findings from face development literature.
The implications of these findings for performance appraisal methodologies and recommendations for further research are discussed.
The implications of these findings for treatment of older adults with suicide ideation and elevated suicide risk are discussed.
The implications of these results are discussed.
The implications of these results are discussed , and recommendations are provided.
The implications of these results for age-related changes in stream segregation are discussed.
The implications of the T2 correction were investigated by studying the age dependence of the T2 -weighted fat fractions and the PDFF.
The implications of this JUPITER subanalysis and the broader role of statins among older adults is the subject of this review.
The implications of this study to a better understanding of the mechanisms underlying the detection of the rate of change in bearing angle are discussed.
The implications of uromodulin glycation and AGEs in the urine are not understood.
The implicit intervention strengthened positive age stereotypes , which strengthened positive self-perceptions of aging , which , in turn , improved physical function.
The importance and implications of these findings for future research are discussed.
The importance , feasibilityand the degree of authority for the psychological index system were graded by two rounds of Delphi method.
The importance of analysis of pneumonia as an underlying cause of death was also highlighted.
The importance of any given role varies by the type of health outcome and timing in the life course.
The importance of bystander effects is becoming more appreciated , as studies show they may affect the course of cancer and other chronic diseases.
The importance of cellular quality-control systems in the maintenance of neuronal homoeostasis and in the defence against neurodegeneration is well recognized.
The importance of ECM remodeling to cancer is appreciated ; the relevance of stiffening is less clear.
The importance of extrinsic factors in skin ageing and the detection of its mechanisms have furthered the development of various therapeutic and preventive strategies.
The importance of genetic susceptibility , epigenetics , aging , and the modern-day environment are highlighted.
The importance of geriatric psychopharmacology will grow further as the average lifespan increases all over the world.
The importance of identifying treatable causes in the frail elderly is strongly emphasized.
The importance of integrating a therapeutic approach into all aspects of social work practice with this population cannot be overestimated.
The importance of investigating gene-gene effects on complex phenotypes has been emphasized , but most imaging studies still focus on single polymorphisms.
The importance of iron in oxidative damage is discussed , along with the three clinically approved iron chelators.
The importance of low NEPA for cardiovascular health and longevity is limited , especially in elderly.
The importance of monitoring PA in the elderly emerged , in particular in those having some certain social-demographic characteristics.
The importance of obesity for certain conditions such as heart disease and type @number@ diabetes is well appreciated.
The importance of physical activity is highlighted.
The importance of providers and HIV-positive peers was discussed most frequently relative to meeting these needs.
The importance of QOL to age bands in different cultures was not significantly affected by whether or not participants perceived themselves to be healthy.
The importance of RNA editing increases with an increase in the organism's complexity.
The importance of telomere length as a prediction marker depends on the analyzed material.
The importance of the early environment on long-term heath and life span is well documented.
The importance of the endocrine environment in the initiation of the ageing process has been elucidated in several in vivo and in vitro studies.
The importance of the in utero environment as a contributor to later life metabolic disease has been demonstrated in both human and animal studies.
The importance of the lens correction on MPOD measurements was confirmed in a simulation study.
The importance of these changes is wide-ranging because of the ubiquitous role of sex hormones in male physiology.
The importance of X chromosome in the aetiology of premature ovarian failure ( POF ) is well-known but in many cases POF still remains idiopathic.
The important biological finding of this work is that some brain regions show periods of accelerated volume loss well before the CSF Aβ42 threshold.
The important changes in body composition associated with aging are a decline in skeletal muscle mass and an increase in body fat.
The important role of modeling in understanding the phenomenon of chemo fog , memory deficit in breast cancer chemotherapy , is explored.
The important role of such changes in morbidity of veterans of extra risk divisions is shown.
The important roles of p21 in the interphase of the cell cycle have been intensively investigated.
The important sex-dependent differences in the developmental programming of diseases seem to be partly secondary to the effects of sex hormones.
The important variability observed within the elderly forces us to take into account their specificities , in particular for ageing physiology and associated comorbidities.
The improved cellular uptake and skin permeation of the CPP-conjugated liposomes were due to the cationic arginine-rich peptide.
The improved glycaemic control during the last decades may have prevented vascular damage from occurring to an extent that would affect organ function.
The improved perception of quality of life was associated with a reduction of @percent@ ( @percent@ CI @number@ to @percent@ ) of the consultations.
The improved performance post-training equaled that of a younger control group and was maintained for at least @number@ months.
The improved tools and mechanistic insights now enable a more efficient development of Sirtuin modulators for in vivo studies and therapeutic applications.
The improvement in accommodation and visual acuity is hard to explain.
The improvement in balance performance did not differ significantly between the stimulations in the two frequency ranges.
The improvement in cognitive functions cannot be explained by blood parameters , such as SpO2 , erythrocytes , hemoglobin , and hematocrit.
The improvement in these outcomes continued for @number@ weeks after the last intervention session.
The improvement of preoperative physical status of these patients is possible and may reduce morbidity and allow faster recovery after major surgery.
The improvement of related symptoms was significant in all groups at 12-month follow-up.
The improvement of the coarse wrinkles was also quantitatively analyzed with a 3D in vivo imaging system.
The improvement score after PRGF use was @number@ ( @date@ ) for the group of patients with signs of skin photodamage.
The improvements in visuospatial skills emerged even though the intervention was restricted to the verbal domain.
The imputations did not significantly affect estimated heritability of BP.
The inability of cells to maintain protein folding homeostasis is implicated in the development of neurodegenerative diseases , malignant transformation , and aging.
The inability to independently grocery shop , a food-related IADL , negatively affects nutritional status and survival among seniors.
The inability to successfully communicate pain in severe dementia is a major barrier to effective treatment.
The inactivation of p53 severely impaired both MALM and MIV generation , leading to accumulation of unhealthy mitochondria.
The inactivation of plasminogen activator inhibitor-1 ( PAI-1 ) has been shown to exert beneficial effects in age-related vascular diseases.
The inactive Y559F-mutant behaved similarly without affecting mitochondrial transcripts.
The inadequate use of drugs can be induced by some factors , like advertisement , with the risk of damaging the user's health.
The in all participants CIMT was measured with ultrasonography at baseline and after a mean interval of @number@ years.
The INAPIC invites international research groups to submit proposals for collaborative projects on these subjects.
The inappropriate administration of folic acid in the presence of vitamin B12 deficiency may lead to both neurologic and , later , hematologic relapse.
The inbreeding coefficient was estimated using the excess homozygosity method with and without adjusting for admixture.
The incidence among men and women over @number@ years of age was @number@ ± @number@ and @number@ ± @number@ P < @number@ respectively.
The incidence and diagnosis of cutaneous malignancies are steadily rising.
The incidence and outcomes of acute exacerbation within @number@ days from the operation were investigated.
The incidence and prevalence of AF increased with advancing age.
The incidence and prevalence of gout increases , and male predisposition to gout reduces , with increasing age.
The incidence and prevalence of heart failure increase strikingly with age and make heart failure the most common reason for hospitalization among older adults.
The incidence and prevalence of older adults living with HIV infection is increasing.
The incidence and prevalence of rheumatologic conditions are increasing and the rheumatology workforce must be aware of aging-specific issues.
The incidence and risk of intraoperative complications in the age groups did not differ statistically ( Duncan's test , P = @number@ ) .
The incidence and severity of herpes zoster ( HZ ) increases with age.
The incidence and the prevalence of this disease will increase with the increase in the number of the aging population of the United States.
The incidence data indicate that incidence of nocturia rises with age and probability of nocturia relief decreases with age.
The incidence , degree , and pattern of cartilage calcification of the sixth through eighth ribs were noted.
The incidence density of falls was @number@ per @number@ person-years.
The incidence , histologic distribution , and clinical manifestations of ovarian tumors in the pediatric population are distinct from those in adults.
The incidence increased to between @number@ and @number@ per @number@ among those @number@ years of age or more.
The incidence is estimated to 3-4 for @number@ Aberrant placental ageing is implicated in a high percentage of birth complications , stillbirths and neonatal deaths.
The incidence is expected to double by the year @number@ owing to the continuous aging of the population.
The incidence is expected to increase in parallel with the aging population.
The incidence is higher among men than women.
The incidence , malignancy and treatment resistance of many types of human B-cell leukaemias ( B-ALL ) are directly related to patient age.
The incidence , morbidity and mortality rates of skin cancers are increasing and , therefore , pose a significant public health concern.
The incidence of acute kidney injury in the elderly has grown over the past decade.
The incidence of acute myocardial infarction in patients undergoing transurethral resection of the prostate is controversial.
The incidence of adjacent segment degeneration was @percent@.
The incidence of AEs was not different between the @number@ preparations , and no patient developed a keloid.
The incidence of AF increased to > 1.12-fold as follows : from @time@ @time@ @number@ person-years ( p < 0.001 ) .
The incidence of Alzheimer disease is increasing due , in part , to increased life expectancy and the aging baby boomer generation.
The incidence of Alzheimer's disease and diabetes is increasing with age.
The incidence of ankle fractures ( AFs ) in the elderly is rising due to the increase in life expectancy.
The incidence of both diabetes mellitus ( DM ) and dementia increases with aging and the incidence of dementia are higher in people with diabetes.
The incidence of both sinus node dysfunction ( SND ) and atrial fibrillation ( AF ) increases with age.
The incidence of both syndromes is much higher in males than females.
The incidence of CAP was @number@.6 / 100 , 000 person-years ( @percent@ confidence interval @date@ @number@ ) in persons aged @number@ years and older.
The incidence of cataract surgery was significantly ( P < 0.001 ) associated with age only.
The incidence of chronic kidney disease ( CKD ) has clearly increased in recent years.
The incidence of CIND was @number@ ( SE , @number@ ) cases per @number@ person-years.
The incidence of cognitive decline after @number@ months in this group of patients is low.
The incidence of cortical cataract additionally was associated with nonsmoking ( P = @number@ ) .
The incidence of CRC has been increasing in recent years.
The incidence of cutaneous squamous cell carcinoma ( SCC ) is rapidly increasing in white populations , causing high morbidity and health-care costs.
The incidence of deep vein thrombosis ( DVT ) and pulmonary embolism has been increasing in the elderly because of hypercoagulability associated with aging.
The incidence of delirium did not differ between the two groups when stratified by surgery type , anesthesia type , or preoperative risk status.
The incidence of dementia and cardiovascular disease ( CVD ) increases with age.
The incidence of dementia and obstructive sleep apnea ( OSA ) increases with age.
The incidence of depression among those without prevalent depression was @number@ per @number@ person-years.
The incidence of differentiated thyroid cancer is increasing worldwide across all age groups.
The incidence of epilepsy is higher among the elderly , the most rapidly growing segment of the population , than in any other age group.
The incidence of epilepsy is high in older individuals.
The incidence of ESRD in the older IgAN patients was @number@ times higher than that in the non-older IgAN patients.
The incidence of falls in the elderly is increasing with the aging of society and is becoming a major public health issue.
The incidence of fever was slightly higher and that of cystitis was lower in the younger group.
The incidence of fragility fractures in Italy is very high , and osteoporosis is the leading cause of morbidity in the Italian population.
The incidence of fragility fractures of the pelvis is increasing quickly.
The incidence of glioblastoma increases with age , with a median age , at diagnosis , of @number@ years.
The incidence of HCC without viral liver disorders was significantly high in the elderly group than in the younger group.
The incidence of heart failure continuously increases in aging societies illustrating the need for new therapeutic approaches.
The incidence of hip fractures is bimodal in its distribution.
The incidence of hypertension was higher than the Hungarian national average for that age.
The incidence of IA was @percent@ among @number@ AML patients and @percent@ among @number@ ALL patients.
The incidence of laparoscopy increased from @number@ % in 2009-23.2 % in @number@ ( p < @number@ ) .
The incidence of LDH drops with age in the elderly , especially after the age of @number@ years.
The incidence of LSS is projected to continue to grow as the population ages.
The incidence of many autoimmune diseases also increases significantly with age , as is evident with rheumatoid arthritis ( RA ) for example.
The incidence of medication-related adverse events can be decreased with careful selection of agents and appropriate dosage adjustments.
The incidence of metabolic syndrome increases substantially during perimenopause and early menopause.
The incidence of mitral regurgitation ( MR ) is rising as a result of an aging population worldwide.
The incidence of one or more falls was recorded after three and six years.
The incidence of osteoporosis-related fracture is similar to myocardial infarction and exceeds that of lung and prostate carcinoma combined.
The incidence of osteoporosis-related fractures in Asian countries is steadily increasing.
The incidence of osteoporotic fractures increases with age.
The incidence of Parkinson's disease by the end of @number@ and the associated risk factors were investigated.
The incidence of perioperative acute kidney injury ( AKI ) is more common than previously recognized , especially in high-risk patients undergoing higher risk procedures.
The incidence of perioperative neurological and surgical complications , bypass patency , bypass function and short-term outcome were retrospectively analyzed.
The incidence of postoperative cognitive dysfunction was observed less often than expected.
The incidence of prostate cancer showed @number@ incremental stages during the 24-year period at an annual average of @percent@.
The incidence of pseudoaneurysm in upper extremities artery is less than lower extremities.
The incidence of renal complications including kidney failure is on the rise.
The incidence of SAH increases with advancing age.
The incidence of self-reported cognitive failures among older adults may be an index of successful cognitive aging.
The incidence of serious AEs was low and they were reported more frequently in the placebo than in the G-GR group.
The incidence of skin cancer among U.S. Hispanics increased @percent@ annually from @number@ to @number@
The incidence of skin cancer continues to increase annually despite preventative measures.
The incidence of systemic fungal infections has risen , as shown by increases in the numbers of immunosuppressed or immunocompromised patients.
The incidence of the atrophic type of OA was significantly higher in older patients.
The incidence of the other known variants was @number@.15-99.85%.
The incidence of these cancers is much lower in Eastern countries but is increasing with Westernisation and increases more acutely in migrants to the West.
The incidence of the small renal mass continues to increase owing to the aging population and the ubiquity imaging.
The incidence of this neoplasm tends to increase with population aging , diabetes and obesity's augmentation.
The incidence of treatment-related morbidity and late mortality with aging is unknown.
The incidence of type @number@ diabetes is increasing at an alarming rate throughout the world.
The incidence of underlying malignant tumor in our study population was @percent@.
The incidence on CT scans was @percent@ ( 95%CI : @number@.44-0.74 ) .
The incidence per million was @number@ and @number@ in women and men , respectively.
The incidence rate for all cancer combined increased by @percent@ annually from @number@ to @number@
The Incidence rate ( IR ) of nonspine fractures was @number@ per @number@ person-years.
The incidence rate is known but detailed epidemiology and pathology data regarding the disease are not available.
The incidence rate of malnutrition was @percent@.
The incidence rate of pancreatic fistula in middle segment pancreatectomy is higher than that in pancreaticoduodenectomy.
The incidence rate of RVO was estimated for the entire Korean population.
The incidence rates for lung cancer will continue to decrease only in men ( down to @number@ per @number@ in @number@ ) .
The incidence rates in all groups increase with age.
The incidence rates of breast cancer rose , reaching a plateau in the mid 2010s.
The incidence rates of symptomatic perioperative pulmonary thromboembolism ( PTE ) in Japan are being investigated by the Japanese Society of Anesthesiologists since @number@
The incidence rates were estimated up to the year @number@ using two scenarios : a linear extrapolation and a last observation carried forward.
The incidence rates were increasing for female lung cancer , male colorectal cancer , and melanoma.
The incidence rate was @number@.2 / 100 , 000 person-years.
The incidence rate was @number@ SDHs per @number@ persons , and the age-standardized rate was @number@.1±4.74 SDHs per @number@ persons.
The incidences of AEs were similar for the two groups.
The incidences of atypical mitosis and anaphase bridges , which are morphological characteristics of chromosomal instability , were negatively correlated with telomere length.
The incidences of bone marrow atrophy and lymph node follicle atrophy in the spleen were significantly increased in @number@ g / kg females.
The incidences of chronic inflammation in @number@ and @number@ g / kg males and females were significantly increased.
The incidences of falls , post intervention , in both experimental groups were significantly lower than those in the comparison group.
The incidences of grade @number@ neutropenia and febrile neutropenia ( FN ) were @number@ and @percent@ , respectively.
The incidences of liver neoplasms were significantly increased in @number@ and / or @number@ g / kg males and @number@ g / kg females.
The incidences of papillary mineralization in @number@ and @number@ g / kg males were significantly increased.
The incidences of porphyrin pigmentation in the Harderian gland of males administered @number@ g / kg or greater were significantly increased.
The incidences of subtrochanteric fractures insensibly increased , while the incidences of femoral neck and intertrochanteric fractures exponentially increased with aging.
The incidence trend was analyzed and the annual percentage change ( APC ) in incidence was calculated by using JoinPoint software.
The incident MCI / dementia group showed an unexpected practice effect in memory from baseline to visit @number@ with a significant decline thereafter.
The incision line can be minimized using intraoperative laser resurfacing immediately after suturing.
The incisive canal was @time@ long and @number@ mm wide.
The included studies displayed significant heterogeneity in both methodologies and clinical populations , which did not allow for a meta-analysis to be completed.
The included studies had a total of @number@ participants , in which @number@ cases of type @number@ diabetes mellitus were recorded.
The included studies lacked sufficient internal validity , sample size , methodological consistency , and standardization of protocols and outcomes.
The included studies needed to have an older group.
The included studies reported FA reduction at @number@ coordinates in ALS and no FA increased.
The inclusion criteria were case-control , cohort studies published in any language.
The inclusion criteria were patients who were @number@ years or older and had a diagnosis of cancer at any stage.
The inclusion criteria were , to be aged @number@ years or older , able to walk and able to carry out daily living activities independently.
The inclusion criterion was age ≥50.
The inclusion criterion was a score > 24 on the mini-mental state examination.
The inclusion of any of these definitions of frailty improved the discrimination of the EuroSCORE II in predicting postoperative delirium.
The inclusion of cognition and gait dynamics in fall classification models reduced misclassification.
The inclusion of relevant biomarkers and functional measurements is also recommended to elucidate the underlying biological mechanism.
The increased binding strength of the TCR repertoire for self-pMHC in neonates was not solely due to reported defects in clonal deletion.
The increased cytosolic GRK2 appears to be colocalized with damaged mitochondria and neurofibrillary tangles.
The increased demand for health care for the aging population creates significant financial burden to any healthcare system.
The increased enzyme levels ( especially of MAO-B ) seemed to correlate with the grade of disease severity.
The increased exercise volume in individuals without MetS may contribute to their better control of insulin resistance than individuals with MetS.
The increased expression of SA-β-GAL indicated an accelerated aging process.
The increased expression of SRF that was observed in the aged heart may affect SIRT2 gene expression and contribute to altered metabolic status in senescence.
The increased functional connectivity within the frontal network was associated with executive dysfunction.
The increased LCs steroidogenic function together with the impairment of inflammatory pathways and BTB structure , result in increased apoptosis.
The increased levels of BMP6 were accompanied by defects in hippocampal neurogenesis in AD patients and APP transgenic mice.
The increased levels of mGluR5 were accompanied by a concomitant increase in the activation of downstream signaling components including ERK , Elk-1 and CREB.
The increased levels of pEGFR and ZNF216 in the nuclear fraction of NIH3T3-EGFR / ZNF216 cells were paralleled by increased levels of phospho-MAPK and phospho-Akt.
The increased morbidity and mortality due to infections among the elderly result from the age-associated decline of the body's defence systems.
The increased mortality rate seemed to be largely explained by age and comorbidities.
The increased mortality risk of other causes of unintentional weight loss may be related to underlying disease.
The increased Nampt during osteoblast differentiation , the enzyme catalyzing NAD resynthesis from nicotinamide was noted.
The increased need for informal care requires resilience and organizational skills of families , but also of volunteers , professionals and employers.
The increased Omega-complexity observed in the elderly is probably caused by reduced interneuronal connectivity.
The increased parietal connectivity may have a role in an attempt to maintain cognitive efficiency in the presence of structural frontotemporal injury.
The increased permeability observed in intimal thickening could represent the substrate on which low-level atherosclerotic stimuli can promote the development of advanced atherosclerotic lesions.
The increased permeability of the blood-brain barrier may relate to endothelial cell activation and activated monocytes / macrophages.
The increased prevalence of obesity and chronic illness in ageing men both cause a large drop in testosterone levels independent of ageing.
The increased proportion of aging and isolation in society is another reason.
The increased recall of recent events possibly obscures the reminiscence bump in the results of younger participants.
The increased risk may potentially be attributed to a negative impact of preterm birth on nephron endowment.
The increased risk of chronic AF was not explained by the occurrence of heart failure.
The increased risk of depression , falls and cardiovascular disease risk in people with dementia will also be highlighted.
The increased Src phosphorylation was also confirmed following treatment with 20GPPD in the human keratinocytes.
The increased stent height , compared with the Sapien XT , led to no complications , especially in mitral position.
The increased waist circumference was independently associated with low values of the low-density lipoprotein levels.
The increase in acetyl histone H3 and H4 was observed in Neuronal N immunopositive pyramidal neurons in Alzheimer's disease brain.
The increase in ADNP2 might be a consequence of neuroleptic treatment , as seen in rats subjected to clozapine treatment.
The increase in ADNP was associated with the initial stages of the disease , possibly reflecting a compensatory effect.
The increase in air pollution over the years has had major effects on the human skin.
The increase in anterior processing began as early as middle-age , was sustained throughout old age , and appeared to be linear in nature.
The increase in BCVA was statistically significant in group @number@ ( P = 0.009 ) .
The increase in cancer survival , added to population aging , will inflate the cancer prevalence.
The increase in central and peripheral fatigue was greater ( p⩽0.01 ) in the young adults vs the older adults.
The increase in copper plumbing use in developed countries parallels the increasing prevalence of Alzheimer's disease.
The increase in depth of the anterior chamber plays a lesser role.
The increase in extra-axial bleeding injury rate was especially prominent in relatively low Delta-V crashes.
The increase in fracture risk may be due , in part , to reduced bone quality.
The increase in Hsp70 negatively correlated with TLR2 and TLR4 downregulation.
The increase in lean mass was predominantly in the legs , while the decreases in fat mass were in the trunk and abdomen.
The increase in life expectancy has dramatically enhanced the prevalence of age-related chronic diseases resulting in growing costs for both society and individuals.
The increase in life expectancy has resulted in a high occurrence of dementia and Alzheimer's disease ( AD ) .
The increase in life expectancy in this period is accompanied by a stable prevalence of most activity limitations.
The increase in mitochondrial membrane depolarization was correlated with activation of effector caspase-3 and cleavage of poly-ADP-ribose polymerase , a vital substrate of activated caspase-3.
The increase in muscle oxidative capacity is due to the combination of strength development and aerobic exercise often used in resistance-type circuit training.
The increase in numbers of people at the oldest ages in the population will bring an increase in the number of people with AD.
The increase in oxidative damage that has been shown to occur with age might be explained by these two processes.
The increase in pCR rate over time suggests improvement in outcome accomplished by a multidisciplinary decision-making process and stringent measures for quality control.
The increase in risk factors for gallstones in Finland implied more marked increase in laparoscopic cholecystectomies.
The increase in SGA augmentation was broad-based , with no significant differences in time trends between demographic and clinical subgroups.
The increase in sputum neutrophils was not secondary to an increase in blood neutrophils.
The increase in sulfur amino acid intake corresponded to half of the sulfur excreted in urinary paracetamol conjugates.
The increase in the application of nonsurgical modalities , particularly injectable shaping agents , has been remarkable.
The increase in the average lifespan and the consequent proportional growth of the elderly segment of society has furthered the interest in studying ageing processes.
The increase in the size of the neuronal LC in elderly people may represent the compensatory reaction of neuroplasticity triggered by the aging process.
The increase may be due to either population aging or improved diagnostic capability or both.
The increase of age predicted less disordered eating.
The increase of choline levels after MPH compared to the levels of choline before MPH in striatum in the combined type patients were statistically significant.
The increase of collagen content in responders ranged from 1-26% , with the mean improvement of @percent@.
The increase of endothelial tube formation induced by BPC @number@ was also inhibited by dynasore.
The increase of glucose , urea and lactate dehydrogenase content in blood was accompanied by growth of blood toxicity.
The increase of life expectancy together with the decline of birth rates implies a global aging of populations living in industrialized countries.
The increase of risk factors for the development of CKD such as hypertension , diabetes and adipositas is essentially responsible for this.
The increase of the number of expression data with multiple platforms could enhance the reliability of coexpression data.
The increase reliance on familiarity was significantly and positively associated with the rate of false alarms.
The increase was found to be maintained at the 1-year follow-up.
The increase was mainly due to the use of vitamin D and calcium.
The increase was seen in three separate human cohorts , totaling @number@ AD and @number@ controls.
The increase with age is more significant in younger subjects compared to older subjects for both men and women.
The increasing age of patients with PCNSL and decreasing renal function limit the intensity of chemotherapy with MTX containing regimens.
The increasing aging population has highlighted the need to deliver post-acute care and to assess its appropriateness.
The increasing burden of ageing populations and their healthcare expenditure is a major challenge worldwide.
The increasing disparity is partly explained by changes in the age structure but is also associated with behavioral and environmental factors.
The increasing frequency of diabetes in the aging population in the United States affects the donor pool.
The increasingly aging population in Europe and worldwide brings up the need for the restructuring of healthcare.
The increasingly functional diversity may lead to more independence between dental development and mandibular growth than during the first two years.
The increasingly important role of patient and carer engagement in management of disease and syndromes is highlighted.
The increasing middle-aged population is leading to the production of many new cosmetic products promising improvement of the various signs of aging , termed cosmeceuticals.
The increasing popularity of this molecule is certainly due to its anti-obesity effect , primarily detected by murine studies.
The increasing prevalence of frailty within the aging population poses challenges to current models of chronic disease management and end-of-life care delivery.
The increasing prevalence of HD has been made possible by growth of the HD capacity.
The increasing prevalence of multimorbidity places additional demands on health-care resources for the elderly.
The increasing prevalence of sarcopenia and critical illness in the elderly has resulted in a deadly intersection of disease processes.
The increasing proportion of overweight and obese people may explain the convergence in time of the mortality rates of the different Italian macro areas.
The increasing share of immigrants in Canada's senior population can affect the demand for hospital care.
The increasing sophistication of modeling techniques is associated with pitfalls that may not be readily apparent to readers or investigators.
The incremental cost-effectiveness ratio for the intervention was @number@ kcal per dollar.
The incremental cost-effectiveness ratio ( ICER ) and bootstrapped cost-effectiveness acceptability curve ( CEAC ) were estimated for routine CT.
The incremental cost of achieving clinically significant changes in major trial endpoints was calculated.
The incremental net cost associated with potentially inappropriate use of antimuscarinic medication was higher under the @number@ Beers Criteria than under the @number@ Beers Criteria.
The incremental utility of reservoir-wave parameters in addition to the Framingham Risk Score was assessed.
The incremental vaccine price of QIV as compared with that of TIV was set at US $ 5.40 per dose.
The increment of collagen and elastic fiber in papillary dermis was confirmed histologically.
The increments in 17-OHP4 , cortisol , A , and progesterone were @percent@ , @percent@ , @percent@ , and @percent@ , respectively.
The increments in LXA₄ and 15-epi-LXA₄ caused by high-dose ASA were significantly greater in LPS-infused rats.
The independent contribution of these factors to motor dysfunction in obese individuals is scarcely defined.
The independent contributions of CRF and PA to metabolic disease risk factors are unknown.
The independent effect of low muscle mass was generally stronger than that of each disease.
The independent factors associated with thinner corneas included older age , lower intraocular pressure and greater corneal curvature.
The independent ( predictor ) variable was the pure tone average of speech frequency ( @number@.5-4 kHz ) hearing thresholds in the better-hearing ear.
The independent risk factors for COPD were smoking , advanced age and male gender.
The independent variables were : age , education , family functioning and multimorbidity.
The independent variables were body mass index ( BMI≥27kg / m RESULTS : The results showed sex differences in all study characteristics.
The independent variable was group type , with @number@ group receiving experimental methods based on the work of Shear et al.
The independent variable was the number of chronic-use medicines taken by older adults , linked to eight chronic diseases investigated.
The index date for each patient was the later of the date HIV care began or @date@ .
The index of ALA-D reactivation was similar to both study groups , but negatively associated with metals.
The index of organic mild impairment ( IOMI ) and IOMI corrected for age ( COMI ) were calculated.
The index single-nucleotide polymorphism ( SNP ) , rs1990622 ( A ) , was associated with more advanced TDP-43 pathology.
The index was reduced in patients with mild cognitive impairment and prodromal AD , indicating a decreased cholinergic activity.
The indication for surgery was typical sagging of the face associated with aging ; the relative contraindications were previous facelift and severe facial atrophy.
The indication for testosterone therapy in aging hypogonadal men without hypothalamic , pituitary , or testicular disease remains to be elucidated.
The indications of each of these therapeutic options have changed over time.
The indicator might also be used for emergency preparedness for identification of regions enriched with frail individuals.
The indicators have also been used in several pharmacoepidemiological studies.
The indicators have likely contributed to this.
The indicators of the functioning of social network ties ( close relations ) , frequency of direct contact and general support were evaluated.
The indicators were representative and well-recognized.
The indices of the ellipse area and velocity COP shifts were calculated.
The indirect effect can help in designing interventions on the mediator as opposed to the exposure and better understanding the outcome's mechanisms.
The indirect effect through IL-6 log units accounted for @percent@ of the total effect between FEV1 and 6MWD.
The indirect links from CVD to the individual measures of the EF composite score via CPS were all significant.
The individual Aβ species separately failed to alter Aβ clearance or the cell-based BBB model integrity.
The individual clinically showed Parkinsonism as a predominant phenotype instead of cerebellar ataxia.
The individual differences of the mucous membrane of the gastroduodenal transition are identified.
The individual experience of the menopause transition varies widely.
The individuals were evaluated for age , presence of dyslipidemia and smoking and for anthropometric parameters for the characterization of body mass index.
The individual with WABS displayed microcephaly , pre- and postnatal growth retardation , and abnormal skin pigmentation.
The induced functions of p53 secure the timely elimination from the organism of damaged and potentially dangerous cells.
The inducer of such externalization was identified by monodimensional gel electrophoresis and mass spectrometry investigations as beta2-microglobulin.
The induction and activation of VEGF receptor @number@ ( VEGFR2 ) were dampened by treating PCE to db / db mice.
The induction of Akt ( Ser473 ) phosphorylation and ROS production by αTP can be attenuated by αT.
The induction of apoptosis was determined by morphological changes and cleavage of poly ( ADP-ribose ) polymerase.
The induction of lipolysis and the thermogenic program could explain the reduction of lipid droplets size.
The induction of senescence of HSCs would accelerate the clearance of the activated HSCs.
The induction of stress responses by curcumin in human cells led to protective hormetic effects to further oxidant challenge.
The industrial processing of tomatoes into tomato-based products includes several thermal treatments.
The industrial production of plant meristem cell metabolites is toxicologically and ecologically sustainable for fully \ "biological \ " anti-age cosmetics.
The industry has responded to these demands with an emergence of noninvasive skin tightening devices.
The infection is life-threatening for infants and immunocompromised individuals , because of direct cytopathicity by viral replication , causing systemic organ injuries.
The infection progresses more rapidly , with higher morbidity and lethality rates.
The inferior and superior cortical edges were detected automatically using a global active shape model image search , followed by an active appearance model search.
The inferior level consistently had the highest concordance.
The inferior temporal gyrus plays an important role in verbal fluency , a cognitive function affected early in the onset of AD.
The inferred rate of gray matter volume loss was significantly accelerated in schizophrenia up to middle age and plateaued thereafter.
The infiltration of M1 macrophages in adipose tissue was also observed in a previously established hamster model of endogenously elevated L5.
The inflammasome is a cytoplasmic multiprotein complex that promotes proinflammatory cytokine maturation in response to host- and pathogen-derived signals.
The inflammation-modulatory activities of the isolates on elastase release and superoxide anion generation in human neutrophils were evaluated.
The inflammatory effects of smoking contributes to the underlying association between inflammation and PAD.
The inflammatory profile was healthier among the premenopausal women compared to the postmenopausal twins.
The inflammatory tissue microenvironment that promotes the development of breast cancer is not fully understood.
The influence of 11βHSD1 in the brain is likely confined to subregions , notably the hippocampus.
The influence of age , gender , and Tanner's classification ( T ) was assessed in children aged > 1 year by ANOVA.
The influence of age , gender , leg length , modified speed or dual tasking is unclear.
The influence of age on CD31 ( + ) T-cell number and function is unclear.
The influence of age on the central and peripheral contributors to exercise-induced hyperaemia is unclear.
The influence of age , sex and CMV-infection on T-cell subpopulations in the peripheral blood remains incompletely understood.
The influence of aging on hearing and vestibular function in patients with auditory neuropathy has not been investigated.
The influence of aging was evaluated with respect to kinematics of the trunk , hip , knee and ankle joints.
The influence of a half-mile walk on the visual acuity of older people who engaged in physical activity was examined.
The influence of androgen level on the age- and blood pressure-related increase in aortic stiffness is unknown.
The influence of ApoE genotype on miRNA biomarker performance was also evaluated.
The influence of biological age on future mortality was analyzed using Cox proportional hazards regression considering gender , chronological age , and event type.
The influence of CCT adjusted for age on IOP readings was analyzed by multiple linear regression analysis.
The influence of education , occupation , and leisure activities on the passive and active components of reserve capacity remains unclear.
The influence of endurance training on cognitive function was assessed by the use of the Vienna Neuropsychological Test Battery and the CERAD test battery.
The influence of estradiol is to promote vasodilation , which , in the skin , results in greater heat dissipation.
The influence of gender on ' p ' and ' t ' was analysed by a Mann-Whitney U-test for each age group separately.
The influence of genetics on ASDD remains to be explored.
The influence of heterogeneity in individual radiosensitivity on estimation of ageing using survival curve is considered.
The influence of hypertension on the aging cardiovascular system has been studied in models of hypertensive rats.
The influence of intestinal bacteria and other factors is also critical.
The influence of leptin level on cognitive function in patients with the metabolic syndrome increases with age.
The influence of marriage and widowhood disappeared after adjusting for all covariates.Our study confirmed the frequent use of psychotropic medications with uninvestigated dyspepsia.
The influence of menopause and exogenous estrogen and progestogens must be included in this equation.
The influence of negative symptoms on functional capacity was partially mediated by processing speed.
The influence of number of languages spoken , education , occupation , and other potentially interacting variables was examined.
The influence of nutritional status upon a person's physical functioning should be considered more broadly in falls research.
The influence of OSA on vascular function is most pronounced in young subjects.
The influence of public urban environment intervention policy on physical activity has been emphasised recently.
The influence of SADW on sleep characteristics was more pronounced on school days.
The influence of sexual attitudes on sexual activity and expression has been relatively understudied in older populations.
The influence of sexual attitudes on sexual activity and expression has been relatively understudied in older populations.
The influence of shared familial factors is unlikely.
The influence of site specificity on the amount of debris and on frictional forces of the first molar tubes could not be demonstrated.
The influence of systolic ( SBP ) vs.diastolic blood pressure ( DBP ) is still controversial.
The influence of the age at onset on β-cell function was investigated in a longitudinal analysis at diagnosis and up to 5-years follow-up.
The influence of the corneal anterior and posterior surfaces on aberrations of the whole cornea was also investigated.
The influence of the environment is taken into account by the parameters of the model , in the general case , depending on the time.
The influence of the GRIN on lens astigmatism and the astigmatic axis is minor.
The influence of the person and the mirror on locomotion and exploratory behaviour was also studied.
The influence of the PICALM genotype on brain function in nondemented subjects remains largely unknown.
The influence of these @number@ factors varied by health condition and type of care.
The influence of the shared environment was not significant at any of the ages.
The influence of this total psoas area ( TPA ) on postoperative morbidity and mortality was evaluated using univariate and multivariate analysis.
The influence of VEGF and bFGF on the mRNA expression of nidogen-1 was studied in vitro.
The influence of WAT may be modulated by SES and cognitive task properties.
The influence of wave reflection on age-related differences in pulse pressure was minor.
The influence on cell-in-cell formation was likely dictated by specific liposome components as some liposomes affected cell-in-cell formation while some others didn't.
The influences of ageing on the diameter , surface topography , nanomechanical properties and tactile perception of hair were determined.
The influences of nutrients and bioactive food components on epigenetic phenomena such as DNA methylation and various types of histone modifications have been extensively investigated.
The influences on the retina image were examined using a Hartmann-Shack aberrometer ( wavelength : @number@ nm ) .
The influential role of the pharmaceutical industry in the process is discussed.
The influenza vaccine often does not provide protection against infection , however , it does provide good efficacy against severe complications related to influenza.
The informants appreciated the adapted physical and social activities and expressed their enjoyment and gratitude.
The informants emphasised aesthetic dimensions in architecture for the prolongation of ageing in place and independent living in a residential home.
The informants felt themselves valued as the persons they were.
The information about the interactions between intrinsic and extrinsic factors for retinal cell fate specification is useful to regenerate specific retinal neurons from RPCs.
The information from the Betula includes @number@ participants from the city of Umeå and VIP includes data for almost @number@ participants.
The information obtained from this work is beneficial in designing nanoparticulate formulations for balancing clinical activity and toxicity.
The information on amounts and types of daily drinking water was recorded by subjects for seven consecutive days using a quantitative measurement.
The information on the levels of metals of industrial , occupational or clinical importance in blood of general Japanese populations is however still scarce.
The information pertaining to health seeking behaviour were collected from them using a pre-designed pretested interview schedule.
The Information Technologies ( IT ) infrastructure of health systems will need to adapt.
The information then is interpreted remotely.
The information was collected through in-depth interviews with @number@ students and graduates and the directors of the three training programs.
The infrared light technique used has turned out to be useful in contrasting skin laxity of the face and other parts of the body.
The infusion of aging content may facilitate further advancement in the field , but additional strategies may also be needed.
The infusion suppressed body weight in the young , aging , and old rats , but not in middle-aged animals.
The ingestion differences did not exceeded the limit of the two standard deviations for the majority of the pairs ( Bland Altman ) .
The inherent affective properties of the words in terms of mean valence and arousal ratings explained more of the variance in the ratings.
The inherent instability of these loci is associated with chromosomal rearrangements in cancers and is a feature of cells from patients with chromosomal instability syndromes.
The inherent limitations associated with records-based studies may have underestimated this risk.
The inhibition constants for AChE were @number@ to @number@ orders of magnitude slower than those for BChE.
The inhibition ELISA showed that anti-CarP antibodies were inhibited by CarALB , but not by citALB.
The inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of ovary.
The inhibition of cysteine cathepsins by specific proteinase inhibitors or chloroquine , which raises cellular pH , restored HDAC4.
The inhibition of proliferation by the N-terminal fragment was independent of its mitochondrial localization.
The inhibition of SIRT1 by siRNA induced OA-like gene expression changes , namely the significant down-regulation of aggrecan and up-regulation of COL10A1 and ADAMTS-5.
The inhibition of SST expression in CRC can be epigenetically regulated by promoter hypermethylation.
The inhibition of the platelet function has been used for a long time in an effort to prevent and treat cardiovascular diseases.
The inhibition of the proteasomal system is one of the major aspects of the cytotoxic effects of lipofuscin.
The inhibition rates have been found to depend on the magnesium ion concentration.
The inhibition rate was independent on the enzyme concentration confirming pseudo-first order conditions.
The inhibitor of cyclin-dependent kinase , p27 , prevents the passage through this critical point in all normal cells.
The inhibitory activity was also based on the suppressed transcriptional activity in MCF-7 breast cancer cells.
The inhibitory adenosine A1 receptor ( A1R ) and excitatory A2A receptor ( A2AR ) are predominantly expressed in the brain.
The inhibitory deficit hypothesis has often been cited as a possible explanation for cognitive changes related to age.
The inhibitory effect of LA-peptide conjugates on melanin synthesis and tyrosinase activity is stronger than that of LA or the pentapeptide alone.
The inhibitory effects on hair cell function are noteworthy given the proposed use of diflunisal to treat neurodegenerative diseases.
The inhibitory processing in the second time window has been associated with the N2 and P3 ERP components.
The inhibitory role of topoisomerase I in mitochondrial transcription is strikingly different from the stimulatory role of topoisomerase I in nuclear transcription.
The in-hospital mortality of IE was @percent@ in the 1990s and @percent@ in the 2000s.
The in-hospital mortality rate was @percent@.
The in-hospital mortality rate was zero.
The initial attempts at harmonising key variables like neuropsychological test scores are in progress.
The initial cognition test was designated PQ1.
The initial concavity of the glenoid osseous surface gradually transformed to convexity , matching the convex glenoid articular surface.
The initial decrease in DMT1 levels in the apical membrane induced by iron was followed at later times by increased levels of DMT1.
The initial electronic search resulted in @number@ @number@ manuscripts.
The initial enthusiasm generated by preclinical studies has been tempered by the modest success of clinical trials assessing therapeutic angiogenesis.
The initial experience with these emerging treatments is encouraging , although much work remains to be done.
The initial @number@ weeks of antidepressant treatment were part of the DOTCODE trial.
The initial procedures developed for facial rejuvenation involve skin resurfacing via complete ablation of layers of skin.
The initial remission rate of CD after the first treatment was @percent@.
The initial sample ( sample frame n = 4518 , random sample n = 700 ) was drawn from the population register.
The initial sample was @number@ caregivers of @number@ veterans with diagnosed dementia.
The initial search yielded @number@ potentially relevant articles.
The initial setting of telomere length ( TL ) in early life has important implications for telomere maintenance and related disorders throughout the life span.
The initial value of %PPP in the oil could help to carry out the storage traceability.
The initiating events of the inflammatory cascade promoting a greater AT inflammatory profile are not completely understood.
The initiation and progression of Alzheimer disease ( AD ) is a complex process not yet fully understood.
The initiation and progression of many human diseases are mediated by a complex interplay of genetic , epigenetic , and environmental factors.
The initiation of intensive chemotherapy is necessary to control further progression of the disease.
The initiation of swallowing was prolonged by both meal consumption and aging ; there was a significant interaction between these two factors.
The initiation of telemedicine programmes can change this situation for better.
The initiative identified medical schools with the necessary components for training academic geriatricians.
The injecting clinician and the subjects were blinded to the contents of the syringes.
The injection of fat and its stromal vascular fraction or expanded mesenchymal stem cells was performed in the preauricular areas.
The injection procedure was performed without local anesthetic for @percent@ of the patients.
The injections were administered in a randomly assigned split-face design.
The injector should be knowledgeable of the advantages and disadvantages of each product.
The innate and adaptive immune systems are important host defences against alphavirus infections.
The innate immune inflammatory response in the TM may play a role in the ABCB1 detoxification of potentially harmful constituents in the aqueous humor.
The innate immune response is regulated at various stages , from hematopoiesis to monocyte changes and macrophage activation.
The innate immune response to band @number@ membrane proteins , and their regulation of cellular lifespan and therapeutic potential will be presented.
The inner possibilities and the social participation were identified as important elements for the elderly self perception.
The innovation of these high-protein and high-energy cookies was the texture adapted to edentulous patients ( Protibis® , Solidages , France ) .
The inpatient geriatric consultation team was involved in only @percent@ of the hospitalizations with at least one change in medication.
The inpatient therapy of patients with severely progressive fibromyalgia is characterized by a high frequency of therapy input.
The input of community partners will ultimately improve population health.
The input of the efferent systems on hair cells occurs during development and persists in the adult cochlea.
The INQ was administered orally , as were measures of social support , death and suicide ideation , and meaning in life.
The INSAT was used ( Work and Health Questionnaire ) .
The insistent efficacy of brain vascular angiogenesis may delay also the comorbid incidence of depressive disorders with dementia pathology.
The insLQ variant was not significantly associated with any of the main outcomes to COH.
The insoles applied sub- or supra-sensory levels of random mechanical vibrations to the feet.
The Institute of Medicine offers a road map for reforming the \ "chaotic and costly \ " delivery of cancer care in the United States.
The institutionalised and those with limited cognition were excluded.
The institutionalization rate was estimated to be @percent@ over @number@ months.
The instrument is able to achieve measures of functional incapacity with the useful properties of the Rasch model.
The instruments were assessed by the researchers who then agreed on the tools to be included in the MHI.
The instrument was applied to @number@ healthy participants , aged 19-75.
The instrument was reduced to @number@ items representing five factors with loadings ranging from @number@ to @number@
The insula , the putamen , and the pallidum were the brain regions most frequently involved in patients with sensory extinction.
The insulin and GIP responses were markedly lower in T than UT and correlated during the first @number@ min after the liquid meal.
The insulin / IGF-1 receptor inhibits the forkhead transcription factor , FoxO through activating a cascade of conserved kinases.
The insulin / IGF-1 signaling pathway is a determinant of aging and age-related diseases.
The insulin / insulin-like growth factor pathway is involved in breast and colorectal cancer ( CRC ) development.
The insulin-mediated suppression of endogenous glucose production and lipolysis did not differ between groups ( all P > @number@ ) .
The insulin receptor exists as two isoforms , IR-A and IR-B , which result from alternative splicing of exon @number@ in the primary transcript.
The insulin signaling pathway is known to influence the aging process ; however , various factors responsible for affecting the aging phenotype are unknown.
The intact aging model fails to achieve very low estrogen levels , and the ovariectomy model lacks a perimenopause phase.
The intake of energy and other macronutrients did not change significantly.
The intake of fruits and vegetables is associated with reduced incidence of many chronic diseases.
The integral component of psychosocial health in overall quality of life and well-being , however , is underscored and requires greater focus.
The integral role of the endothelium during the coordination of blood flow throughout vascular resistance networks has been recognized for several decades now.
The integrated impact of the RAS on glucose homeostasis is still a matter of debate.
The integrated status of major CVD risk factors can determine lifetime cardiovascular health and CVD risk in Chinese.
The integration and control of systemic immune responses depends on the regulated trafficking of T-lymphocytes.
The integration of autophagy into these biological functions and other stress responses is determined by the transcriptional factors that undertake the regulatory mechanism.
The integration of both epidemiological and clinical data promises to create more robust models that shed new light on physiological processes.
The integration of CAGE and ChIP-chip analyses successfully identified a cluster of androgen-inducible miRNAs , as exemplified by the miR-125b-2 cluster on chromosome @number@
The integration of frailty measures in clinical practice is crucial for the development of interventions against disabling conditions in older persons.
The integration of modeling and simulation tools allowed the identification of system bottlenecks.
The integration of multisensory information is essential to forming meaningful representations of the environment.
The integration of rich clinical data , quantitative proteomic technologies , and tailored computational modeling facilitated the characterization of these signatures in patient circulation.
The integration of these factors could allow centenarians to maintain moderate levels of free radicals that exert beneficial signaling and modulator effects on cellular metabolism.
The integration of TIgGER into Rep-Seq processing pipelines will increase the accuracy of V segment assignments , thus improving B-cell repertoire analyses.
The integrative symposium investigated different aspects of alcohol-induced liver disease ( ALD ) as well as non-alcohol-induced liver disease ( NAFLD ) and possible repair.
The integrity ( FA values ) in selected fiber bundles correlated strongly with cognitive measures on executive function and processing speed.
The integrity of epithelial barriers is compromised , leading to a chronic , subclinical inflammatory state and an enhanced Th2 ( allergic ) immune response.
The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents.
The integrity of selective thalamic nuclei and projections decline with advancing age , particularly those in thalamofrontal , thalamoparietal , and thalamolimbic networks.
The integrity of the canalicular network might influence bone quality and reflect its mechanosensory potential.
The integrity of the endothelial cells , which line the entire circulatory system like wallpaper , is essential to prevent the onset of cardiovascular disorders.
The integrity of the lung endothelial cell ( EC ) monolayer is critical for preservation of lung function.
The integrity of these neural regions are affected in aging and neurodegenerative conditions.
The integrity of the vascular system is essential for the efficient functioning of the brain.
The integromics meta-analysis approach can serve as an efficient subvening signature tool for more-oriented better-designed experiments.
The intellectual autonomy of elderly people must be preserved.
The intellectual working capacity and indicators of time of reaction to visual , acoustical and skin signals in older persons were studied.
The intensity and duration of these effects are influenced by dose and half-life of the NSAID.
The intensity distributions on the retina for both on- and off-axis illumination are calculated.
The intensity of depressive symptoms was assessed using the Polish version IA of Beck Depression Inventory ( BDI ) .
The intensity was feasible for participants who continued the MI-WP.
The intensive work in this area throughout the world has created an urgent need for a unified language.
The intention of surgery in all cases was curative resection with ileo-colic anastomosis.
The intention of the eighth symposia was to advance the international profile of the biological research on alcoholism.
The intention of the review is to summarize the data regarding the uses of jojoba in dermatology for readers and researchers.
The intention of this study was to provide a simple , yet reproducible classification and to offer appropriate rejuvenation approaches.
The intent is to spread the ACE Strategy's elder-friendly models of care and practices to @number@ participating healthcare delivery organizations.
The intent of this review is to describe the range of BER capacity among individuals and the functional consequences of BER genetic variants.
The interacting molecular pathways which control bone remodeling in physiological conditions during a lifelong process are described.
The interaction between age and APOE genotype on rate of decline suggests that preclinical disease may be overrepresented in older ε4 + individuals.
The interaction between age and diabetes was not significant for all outcomes.
The interaction between botanicals and macronutrients that modulates life span is not well understood.
The interaction between cardiolipin and cytochrome c determines whether cytochrome c acts as an electron carrier or peroxidase.
The interaction between DCs and AECs plays a crucial role in lung immunity at homeostasis and during infections.
The interaction between depression and APOE genotype was not statistically significant.
The interaction between functional limitations and environmental barriers generated a score expressing the magnitude of P-E fit problems in their home environment.
The interaction between gender and IQ was not statistically significant.
The interaction between genetic factors and micronutrients ( nutrigenomic and nutrigenetic approaches ) may influence ageing and longevity because the micronutrients may become also toxic.
The interaction between metabolic and demographic factors on ALT variation has also been discussed in previous studies.
The interaction between pharmacology and nutrition science is on the rise.
The interaction between red meat intake , NAT2 genotype , and colorectal cancer has been inconsistently reported.
The interaction between statin exposure and 3MS was significant for total-WMH and WM FA ( both P < @number@ ) but not GM MD.
The interaction between TAK1 and EGFR in H. pylori-infected cells might open new dimensions in understanding H. pylori-associated gastric carcinogenesis.
The interaction between TDP-43 and the FOXO pathway in mammalian cells is mediated by their competitive binding to 14-3-3 proteins.
The interaction between these contents is pivotal to understand the research on ageing.
The interaction between VASH1 and SVBP was confirmed using the BIAcore system and immunoprecipitation analysis.
The interaction effect between gender and sexuality was also tested.
The interaction effect between relative deprivation and relative poverty was not associated with poor health.
The interaction effect ( JPA × Cognitive activity ) was nonsignificant.
The interaction effect of education and age on cardiovascular risk factors was tested by including an interaction term.
The interaction effect remained significant after statistically controlling for relevant variables , including education and gender.
The interaction effects between self-focused attention / depressive symptomatology and objective memory performance on the severity of SMI were not significant.
The interaction of ABAD with Aβ exacerbates Aβ-induced mitochondrial and neuronal dysfunction.
The interaction of age with shift rotation in relation to sleep-wakefulness and inflammation were studied among male employees ( n = @number@ ) .
The interaction of amyloid beta peptide ( Aβ ) with CypD potentiates mitochondrial and neuronal perturbation.
The interaction of deltaE ab values were analyzed by two-way analysis of variance followed by Newman-Keuls Multiple comparison test.
The interaction of FAM96B with prelamin A was confirmed by GST pull-down and co-immunoprecipitation experiments.
The interaction of free radicals with antioxidants is a topic of increasing interest in the development of prevention strategies against skin ageing.
The interaction of genes with their environment , may explain ND.
The interaction of midlife alcohol consumption by age at stroke was evaluated in Cox-regression and analyses of monozygotic twins were used.
The interaction of the liposomes with the plasma membrane triggered the stimulation of neutrophils.
The interaction of the peptide with native crystallin was studied by multi-angle light scattering and fluorescence methods.
The interactions between experience-dependent and injury-induced neural plasticity are complex , time-dependent , and varied with age and other factors.
The interactions between number of chronic conditions with wealth were significant at the @percent@ level.
The interactions between PfS and social isolation on SI and SH were also investigated.
The interactions of duration x age group and duration x hearing level were not significant.
The interactions of modeling parameters suggested that cognitive changes were the cause of lowered performance in older adults.
The interactions of Schwann cells , axons , macrophages , and mast cells via cell-cell and cell-matrix signaling regulate the permeability of this interface.
The interactions of these molecules and influence on beta-amyloid peptide synthesis and contribution to ischemic brain degeneration and finally to dementia are reviewed.
The interaction term was significant ( P = 0.024 ) .
The interaction term WMLs TICV was also significant.
The interaction was not significant in control and AD dementia groups.
The interactive effect of gene polymorphisms associated with folate metabolism may modify the risk of developing hearing impairment after middle age.
The intercapillary distance in the papillary dermis singnificantly increased during the 8th decennium.
The intercarpal ligaments demonstrate an age-related progression of laxity of the SL and lunotriquetral joints.
The intercorrelation among the morphologic indices may dampen the use of individual morphological parameter in featuring cerebral structural alterations.
The inter-correlations of these outcome measures were fair to moderate supporting their distinctiveness.
The interest for this enzyme stems from the fact that it is involved in glycolysis , but also in aging , human diseases and metabolism.
The interest in the action of nicotine in the central nervous system ( CNS ) has significantly increased during the past @number@ years.
The interest in this compound has increased dramatically over the last few years and many studies are now applying this molecule across many disease models.
The interference effect was predicted by the psychometric tests designed to evaluate inhibition.
The intergenerational programs provide opportunities to fulfil basic human needs and reintegrate older adults into society.
The intergroup analysis used was the logistic regression.
The inter-hemispheric increased synchronization values could reflect a compensatory mechanism for the lack of efficiency of the memory networks in MCI patients.
The interleukin-10 ( IL-10 ) gene regulates the production capacities of IL-10 and tumour necrosis factor-α ( TNF-α ) .
The internal consistency and construct validity of the FaB-FC were studied among @number@ community-dwelling adults aged @number@ and over.
The internal estimate of verticality can be assessed through the subjective visual , haptic , or postural vertical ( SPV ) .
The internal gradient index distribution adapts to the external shape so that the analytical expression is invariant with the changes with age and accommodation.
The internal reliability of the new tasks and questionnaires was analyzed , as well as their relationship with the spatial and working memory tests.
The internal validity was estimated using bootstrap techniques.
The International Classification of Functioning , Disability and Health ( ICF ) was employed as the theoretical model.
The international clinical diabetic retinopathy and macular edema disease severity scales are very useful for information sharing between ophthalmologists and diabetologists.
The international community views this practice as a human rights violation.
The International Index of Erectile Function ( IIEF ) -5 and International Prostate Symptom Score were recorded for each patient.
The International Knee Documentation Committee ( IKDC ) subjective score improved from @number@ ± @number@ to @number@ ± @number@ at the final evaluation.
The International Osteoporosis Foundation's ( IOF ) latest figures show that globally about @percent@ of the population does not have an optimal vitamin D status.
The International Physical Activity Questionnaire ( IPAQ ) and accelerometers were used to measure levels of PA.
The International Physical Activity Questionnaire ( short form ) measured PA in metabolic equivalents.
The international residential assessment instrument ( interRAI ) has been adopted for phased national implementation in New Zealand.
The Internet affords numerous opportunities for individuals of all ages to communicate , access information , and engage in recreational activities.
The interocular difference remained stable despite significant decrease in RNFL thickness with aging.
The interocular differences in RNFL thickness were calculated , and normal ranges of interocular differences were determined as the @number@.5th and @number@.5th percentiles.
The interplay of neuroendocrine processes and gonadal function is exquisitely expressed during aging.
The interpolation of Markov Chain method was used to estimate gender differences in TLE , DLE , and DFLE.
The interpretation and the application of these biomarkers are here presented.
The interpretation of BASMI scores has been hindered by the absence of normative values.
The InterRAI assessment tool for ED´s was used by nurses to assess participants.
The interRAI IADL-ADL Functional Hierarchy Scale was created through an amalgamation of the ADL Hierarchy ( developed previously ) and IADL Hierarchy Scales.
The interRAI instrument for long-term care facilities was assessed by trained staff at baseline and @number@ months later.
The interrater agreement of individual scoring criteria was analyzed and items with poor or moderate reliability were excluded.
The interrater agreement κ statistics were @percent@ for vertebral wedging and @percent@ for endplate irregularity.
The inter-rater and intra-rater reliability of measuring muscle thickness with the ultrasound scanner and the validity of the target point were demonstrated before the examination.
The interrater reliability estimates indicated excellent reliability ( κ values > 0.81 , percentage agreement @number@.1%-96.1% ) .
The inter-rater reliability for the Persian version of Word Association Test was @number@ and that for the English version was @number@
The inter-rater reliability was ρ = 0.991 and ρ = 0.999 for the caregiver distress.
The interrelation between aging , obesity , CVD , frailty and inflammation is a current issue of intensive research.
The interrelationship between frailty and DM deserves further investigation.
The interrelationships of growth hormone ( GH ) actions and aging are complex and incompletely understood.
The inter-relationships were assessed using both mediation analyses and general linear models.
The inter-relationship with the vertebral body and articular facets is discussed.
The intersection of aging and HIV / AIDS is a looming ' epidemic within an epidemic. '
The interval between initial administration and death was @number@ to @number@ days.
The interval between the midlife ascertainment of PA and late-life cognitive function was @number@ years.
The interval from transitional living to institutionalization was @number@ ± @number@ months.
The intervals between the lines ranged from 50-100 cm and were unequal.
The intervention appeared to have smaller effects on expenditures as BMI level increased.
The intervention carried out in the states of California , Texas , and Washington DC.
The intervention coincided with all parties committing to the single largest annual increase in spending on families with children in over a decade.
The intervention comprises four group meetings ( 'senior meetings' ) and one follow-up home visit made by a multi-professional team.
The intervention consisted of 5-7 sets of @number@ s timed bilateral hopping exercise at 75-90% intensity three times / week.
The intervention consisted of a first meeting with health professionals and additional five self-care telephone calls.
The intervention consisted of at least two visits from nurses ( 2-3 weeks apart ) to identify , review and address caregivers ' needs.
The intervention consisted of biweekly , 60-minute group sessions in all primary health care settings in the city.
The intervention consisted of @number@ hrs / day , @number@ days / wk for @number@ wks.
The intervention consisted of providing @number@ weekly MCAs during the monthly visit.
The intervention consisted of STOPP recommendations made by the IGCT to ward physicians to discontinue PIMs , in addition to the standard geriatric advice.
The intervention consisted of twice-weekly 70-min lessons for @number@ weeks.
The intervention costs were $ 1.27 per person per day higher than usual care ( P < @number@ ) .
The intervention focused on supervised , aerobic and resistance exercises ( mainly leg press ) , and included @number@ weekly sessions.
The intervention for the worksite study was Booster Breaks ( a physical activity routine of @number@ minutes ) practiced daily to break-up prolonged sitting time.
The intervention group completed @number@ training sessions ( @number@ min , @number@ weeks ) .
The intervention group demonstrated enhanced memory and social support compared to the control group.
The intervention group received a 30-min EA treatment on a weekly basis for @number@ weeks , while the control group received a sham treatment.
The intervention group received a case management intervention which comprised monthly home visits during @number@ months by nurses and physiotherapists employing a multifactorial preventive approach.
The intervention group received activities of daily living retraining three times per week for up to one hour per session.
The intervention group received a median of @number@ home visits from the study occupational therapists.
The intervention group received booster education every visit by viewing a 15-minute educational video.
The intervention group received psychoeducation from a registered social worker over the phone for @number@ sessions.
The intervention group receives ESS plus usual rehabilitation and the control group receives sham ESS plus usual rehabilitation.
The intervention group ( REPRINTS ) was recruited through intensive weekly training seminars for three months.
The intervention group was given an enteral formula containing lactic acid bacteria-fermented milk products.
The intervention group will receive geriatric physiotherapy according to the Coach2Move strategy.
The intervention had no effect on caregiver burden.
The intervention in both groups consisted of ten 50-minute sessions delivered remotely during @number@ weeks ( @percent@ by telephone ) .
The intervention included seven 90-min , weekly sessions that were based on a standardized self-designed schedule.
The intervention included the following components : patient education , health promotion coaching , medication management , and physician care management.
The intervention , including exercise , health education , and social activities , was performed @number@ hr per week for @number@ weeks.
The intervention involved @number@ weekly RMM sessions.
The intervention is aimed at enhancing well-being and future planning among older adults with macular degeneration by increasing preparation for future care.
The intervention is a multifaceted educational program.
The intervention is applied as @number@ h of ESS / sham ESS daily , followed by motor training of the affected upper limb.
The intervention itself was found to be feasible , but elaborate and time consuming.
The intervention model used an algorithm and was multifaceted for both patients and their primary care providers.
The intervention offering low frequency had a positive effect on cognitive function in patients with chronic diseases.
The intervention participants had a significantly lower 1-year institutionalization rate ( @percent@ ) than the control group ( @percent@ ) .
The intervention period ( divided in two subperiods ) was compared with a control period.
The intervention period is @number@ months.
The intervention promoted positive affect and improved psychological outcomes for family caregivers of people with FTD.
The intervention rate could be greatly increased by better registration of information on renal function.
The intervention showed that women improved more than men.
The intervention significantly improved scores in all @number@ GEMC domains ( improvement @percent@ to @percent@ ; p < 0.001 ) .
The interventions lasted @number@ weeks and each group performed identical exercise intensity and volume per session.
The intervention socially activated the participants , and their feelings of loneliness had been alleviated during the intervention.
The interventions ranged in their impact on health and social outcomes but reductions in perception of caregiver burden were consistently observed.
The intervention successfully improved some parameters of aerobic fitness , i.e. ventilatory thresholds @number@ and @number@ ( P < 0.05 ) .
The interventions were implemented in a short-form group format.
The intervention was a two-phase targeted intervention falls prevention program.
The intervention was completed as planned , physical resources were suitable , and financial resources were adequate.
The intervention was composed of a 6-week program of combined activities including cognitive training , Tai Chi exercise , and group counseling.
The intervention was conducted over @number@ weekly sessions and involved individual instruction.
The intervention was delivered in different conditions ( i.e. print-delivered versus Web-based , and with or without additional information on local PA opportunities ) .
The intervention was designed to be translated into clinical or community-based programming.
The intervention was finalized with an award ceremony for the best intraprofessional team.
The intervention was from day @number@ to @number@ of life until the infant's expected date of delivery ( EDD ) .
The intervention was marketed as a \ "dinner theater \ " to farm couples.
The intervention will comprise multicomponent group exercise sessions , nutrition education , oral care education and on-going support and counselling.
The intervention with the MD did not change 1-year levels of these metabolites.
The intervertebral disc ( IVD ) is a joint unique in structure and functions.
The interview data constitute the basis for the definition of MCI cases ( gold standard ) .
The interviewees emphasized the importance of practical experience , although many of them encountered some degree of antagonism during their training or placement.
The interviewees had difficulties with the GP out-of-office hours services.
The interviews were analysed using the constant comparative method in the grounded theory approach.
The interviews were analyzed to identify themes.
The interviews were conducted in New York and New Jersey using a phenomenological approach ( Moutsakas , @number@ ) .
The interviews were transcribed and analyzed using thematic analysis.
The interviews were with @number@ participants who were national experts in senior transportation in the United States.
The interview texts were analysed by means of discourse analysis.
The interview texts were analyzed using manifest and latent content analysis.
The intestinal microbiota is essential for nutrient acquisition , immune development , and exclusion of invading pathogens.
The intestinal parasite , Anisakis simplex , has an immunomodulatory effect.
The intestine , liver and kidneys each play essential roles in regulating body folate homeostasis.
The intimal compressive component compensates part of tensile stress induced by blood pressure , hence reduces severity of endothelial tension.
The intra- and extracellular axial diffusivities as estimated with WMTI do not change appreciably in normal brain development.
The intracellular and extracellular water in the upper and lower legs were assessed by segmental bioelectrical impedance spectroscopy.
The intracellular Ca ( 2 + ) in brain tissues is increased with aging.
The intracellular Ca content was modulated by the Ca ionophore A23187 and by varying the Ca concentration in the medium.
The intracellular iron accumulation would lead to a rise in oxidative damage , contributing to AD pathophysiology.
The intracellular LFLP formation rate is negatively correlated with the life expectancy of cell.
The intracellular ROS content displayed @percent@ increase ( p = @number@ ) in BSO compared to the control.
The intracellular ROS level was strongly reduced immediately after treatment with these compounds , showing that they are potent antioxidants.
The intracellular zinc homeostasis is mainly regulated by Metallothioneins ( MT ) , via ion release through the reduction of thiol groups in MT molecule.
The intra-class correlation coefficients ( ICC ) presenting test-retest reliability were all over @number@
The intraclass correlation coefficient values of the HRV indices varied from @number@ ( very large ) to @number@ ( near perfect ) .
The intragenic methylation changes are overrepresented in genes that guide the formation of the junction of the motor neuron and myofibers.
The intraindividual variability ( IIV ) of cognitive performance has been shown to increase with aging.
The intramuscular collagen FSR was evenly increased following LL- and HL-RE and was not affected by feeding.
The intranasal route can thus transport drugs directly to the brain from the nasal cavity along the olfactory and trigeminal nerves.
The intranasal route is composed of two pathways , one being intracellular while the other being extracellular.
The intraocular pressure ( IOP ) was measured with an induction-impact tonometer.
The intraoperative complications which occurred during the operation were recorded.
The intraorbital fat protrusion in the lower eyelids occurs as an aging process , and the protruded fat is routinely removed during aesthetic surgeries.
The intrarenal RAS plays a key role in promoting tubulointerstitial fibrosis.
The intrauterine environment is a major contributor to normal physiological growth and development of an individual.
The intravenous infusion of apolipoprotein E4 exacerbated the brain accumulation of aggregated amylin and vascular pathology in HIP rats.
The intricately interwoven role of detailed autobiographical memory in our daily lives and in our imaginative envisioning of the future is increasingly recognized.
The intriguing lack of differences in lifespan in such pairs implies that PA is not an important life prolonging factor.
The intrinsic aging process of the skin in unavoidable and depends on the passage of time per se.
The intrinsic complexity of ageing remains a significant challenge to understand the cause of this natural phenomenon.
The introduction of high-resolution ultrasonography provided a long-awaited tool to image the reproductive tissues in situ in both animals and humans.
The introduction of intravenous immunoglobulin decreases the incidence of coronary artery lesions to less than @percent@.
The introduction of less invasive procedures has increased acceptance of such procedures.
The introduction of MRI conditional pacemakers will enable more patients to undergo routine MRI assessment without risk of morbidity or device malfunction.
The introduction of new drugs including novel monoclonal antibodies and kinase inhibitors offers enhanced opportunities for the treatment of elderly patients with CLL.
The introduction of novel agents such as thalidomide , lenalidomide and bortezomib has significantly improved the outcome for MM patients , including the elderly.
The introduction of open visiting and care rounding has reduced the risk of isolation in single rooms.
The introduction of recombinant proteins has allowed manufacturers to produce large amounts of the proteins usually present at very low concentration in blood.
The introduction of regorafenib expands the currently limited range of effective treatment options in patients with previously treated , progressive mCRC.
The introduction of walking training positively influences the menopause immune-neuroendocrine changes , independent of ACE I / D genotype.
The intronic single-nucleotide polymorphism rs707284 in ERBB4 links to PI3K-AKT suppression in SZ.
The intron @number@ VNTR polymorphism in the XRCC4 gene showed an association with RA patients.
The inventory of processes that miRNAs regulate has continued to expand since their relatively recent discovery.
The inverse association between ESR1 and age persisted after adjusting for trunk fat mass , estradiol , or leptin.
The inverse association between longevity and LC-FFA persisted after correction for body mass and phylogenetic interdependence.
The inverse associations were primarily related to cardiovascular disease mortality but not to cancer mortality.
The inverse comparison of placebo versus caffeine had no significant difference.
The inverse correlation between TERT or TERC expression and gestational age was steadily observed in these fetus tissues.
The inverse proportion between mortality and age fitted in @number@ of @number@ cases before mortality minimum.
The inverse proportion between mortality and age is used from birth to the age when all-diseases mortality reaches the minimum value.
The inverse relationship in these RNA pairs suggests miRNAs regulate mRNA levels on aging and between genders.
The investigated inflammatory parameters were interleukin @number@ and C-reactive protein.
The investigated persons had less percent of mortality and a significantly higher systemic pressure as well as higher value of the variable Jung.
The investigated population consisted of @number@ individuals aged @number@ and more - participants of the population-based PolSenior project.
The investigation of abuse or neglect may be more difficult because of aging changes.
The investigation of CHD as guided by a complex genetic model could help estimate risk more precisely and logically lead to a means of prevention.
The investigation of glaucoma effects on LGN volumes demonstrates that the bilateral LGN volumes shrink in patients.
The investigation of pressure waves leads to understanding the propagation characteristics of a pulse wave.
The investigations included socio-demographic data , health status , lifestyle and anthropometric measurements.
The investigator and a blinded evaluator assessed patients @number@ days after treatment and then every @number@ days after the initial treatment session for @number@ days.
The investigators interpreted this result as reflecting the ability of L1 listeners to rapidly segregate the target words from a masker.
The invitation was either in a brown or white envelope and contained a matching pre-paid reply envelope.
The in vitro activities were used to calculate normalized hepatic clearances using both allometric scaling and a physiologically based pharmacokinetic model.
The in vitro coculture experiments showed that uMSCs only inhibited lymphocytes and splenocytes proliferation but not mesangial cells.
The in vitro cytotoxic assays showed that KA-unloaded LCS and KA-loaded LCS didn't present cytotoxicity.
The in vitro experiments showed that OB-plasma significantly impaired endothelial insulin-stimulated NO production and bioavailability compared to CTRL-plasma.
The in vitro lifespan was determined by both replicative and stress-induced senescence mechanisms.
The in vitro release studies for both films showed a burst drug release , followed by prolonged release for @number@ h.
The in vivo force applied to the SMAS was found to be only @number@ percent of its total bursting strength.
The in vivo imaging also demonstrated that Sox2 ( / ) 3 ( + ) neural progenitor cells generate neurons in response to injury.
The in vivo imaging characteristics of VMAT2 is consistent with the expression of VMAT2 in a recent autopsy study.
The in vivo results indicated that down-regulation of GJA3 in lens epithelial cells was associated with age-related cataract genesis.
The in vivo results showed a reduction in bacterial load on the ureteral stent tissue of the pre-treated strain.
The in vivo significance of this oncogenic switch is highlighted by demonstrating CPI-17's involvement in human melanoma pathogenesis.
The in vivo skin capacitive images were taken by a capacitance based fingerprint sensor , the skin capacitive images were then analysed by GLCM.
The in vivo study confirmed that the sunscreen prevented UVA radiation-induced transcriptional expression of the five studied genes.
The in vivo study was performed on the STR / OrtCrlj mouse , an experimental model which spontaneously develops an osteoarthritic process.
The involvement of abnormal MSC differentiation in cancer is then discussed.
The involvement of antagonist muscle co-activation remains unclear.
The involvement of Bregs in cancer remains poorly understood despite their well-documented regulation of responses to the self and protection from harmful autoimmunity.
The involvement of endocytosis was also studied by testing several endocytic mutants and by following the vacuolar delivery of the probe FM4-64.
The involvement of motor-associated cortices during recognition of a personal enemy may reflect readiness for attack or defense.
The involvement of rarer variants in these loci has been poorly studied.
The involvement of the IIS pathway in regulating longevity and response to a variety of stresses is well documented.
The involvement of the superior parietal lobe even during rest is a strong indicator for its key role in AV synesthesia.
The involvement of transcription factor YY1 might be a novel mechanism for the development of AD.
The IOP level was not changed in the SOD1-deficient mice.
The IOP-lowering effect of drugs is based on meta-analyses and applied by Monte Carlo simulation to a hypothetical cohort of patients with OH.
The IOR patterns varied minimally with age , consistent with the conclusion that older adults and young adults distributed inhibition in a similar manner.
The iPSC-MSCs showed adequate capacity of osteogenesis and chondrogenesis compared to the BM-MSCs , while less adipogenic potential was found in the iPSC-MSCs.
The iPSCs formed teratoma containing the structures developed from all three germ-cell layers in severe combined immune-deficiency mice.
The iPSCs were differentiated into neural progenitors , endothelial cells , fibroblasts , VSMCs , and mesenchymal stem cells ( MSCs ) .
The IPSS includes scores for @number@ questions on voiding symptoms , @number@ on storage symptoms , and @number@ on postmicturition symptoms.
Their 3-year progression rate to Alzheimer's disease-type dementia was @percent@ compared to @percent@ for subjects without prodromal Alzheimer's disease.
Their 3-year progression rate to Alzheimer's disease-type dementia was @percent@ compared to @percent@ for subjects without prodromal Alzheimer's disease.
Their ability to self-renew and differentiate into several lineages makes them a promising tool for cell-based therapies in different types of degenerative diseases.
Their absorption and emission spectra were similar to those of A2E.
Their absorption from foods , metabolism , their effects on physiological and pathological processes , and the mechanisms of action are intensely investigated.
Their accumulation in the elderly people , as reflected by skin autofluorescence ( sAF ) , may be a marker of metabolic memory.
Their accuracy as ADHD markers is increasingly questioned but may improve with pattern classification.
Their activation causes intra- and intermitochondrial redox-environment changes leading to ROS release.
Their advantages and limitations are presented : sacroplasty , iliosacral screw osteosynthesis , cement augmentation , transiliac internal fixation , trans-sacral osteosynthesis , lumbopelvic fixation.
Their age ranged from @number@ to @number@ years with a mean ( sd ) of @number@ ( @number@ ) years.
Their age range was 20-80 years.
Their age range was 66-98 years ( mean age @number@ ± @number@ years ) , @percent@ were females.
Their ages at the initial MI ranged from @number@ months to @number@ years ( median , @number@ years ) .
Their ages ranged from @number@ to @number@ years ( @time@ ± @number@ years [ mean ± SD ] ) .
Their aggregation appears to give rise to large RFs.
Their aging in vitro is thus also an important consideration.
Their answers to the questionnaire were then reviewed using content analysis.
Their antitumor efficacy has been confirmed by in vitro and in vivo studies.
Their application may help physicians in the selection of invasive and medical treatments and in the timing and modality of the follow-up.
Their attitudes , perceptions and understanding regarding AD were captured in the IMPACT survey , a 30-minute Web-based questionnaire.
Their average monthly salary was @number@ ± @number@ € ( range : @number@ to @number@ € ) .
Their average posttest score gain was @percent@ ( p = 0.012 ) .
Their balance was assessed with stabilographic platform CQ Stab 2P.
Their better support networks were close relationships and relatives.
Their bioactivity in health and disease is underexplored.
Their blood was collected and assayed spectrophotometrically for oxidative protein damage in terms of protein carbonyls and plasma antioxidant capacity in terms of FRAP.
Their brain morphometric features may be used as normative references for patients with suspected neurodegenerative disorders.
Their capacity to remove aged , damaged cells is well established.
Their cognitive deficits correlate with everyday functional limitations.
Their concentration is strongly correlated with synaptic impairment in animals and parallel cognitive decline in animals and humans.
Their cumulative effects are , however , large.
Their cytotoxicities were tested against cancer cells ( PC3 and MCF-7 ) and lymphocytes.
Their data indicate that the two pathologies arise in different ECMs.
Their data were collected and retrospectively analyzed.
Their data were compared with a dataset obtained in a similar earlier study of young subjects.
Their decrease in response can be attributed to both optical and neural factors.
Their demographic characteristics , cognitive function , their balance , falling risk and their physical fitness level have been evaluated.
Their dental and labial stone casts were obtained , digitized , and virtually reproduced using a computerized electromechanical digitizer and applying nonuniform rational B-spline geometry.
Their dental casts were digitized with a 3-dimensional ( 3-D ) laser scanner , reconstructed into 3-D images , and measured with IMAGEWARE.
Their diagnostic criteria are similar to those used for younger patients.
Their distribution was recognized to be a major determinant of metabolic risk.
Their dysfunctions are associated with aging , cancer , obesity , and inflammation.
Their efficacy , along with minimal downtime , has enabled an effective and safer treatment.
Their efficacy in reducing photocarcinogenesis and photoaging is widely documented.
Their eGFR was calculated using the MDRD , CKD-EPI , their respective modified equations for Chinese , and the diabetes specific CKD-EPI Chinese T2DM equations.
Their empirical significance levels and power are studied using simulations.
Their evaluation could be a useful tool with a view to ascertaining vinegar origin and genuineness.
Their experiences and beliefs need to be considered for developing effective interventions to improve sleep , waking function , and wellbeing.
Their explanation of cancer phenotypes is based on the premises adopted by the somatic mutation theory ( SMT ) and its cell-centered variants.
Their expression and significance increase with age and with the progression of diabetes , two major contributors to the development of atherosclerosis and its complications.
Their expression in apparently normal white matter in cases with WML suggests that white matter dysfunction is not restricted to lesions.
Their expression is selectively controlled by the modulation of mRNA levels and translational recoding efficiencies.
Their extent of leukoaraiosis measured by the Fazekas scale was correlated with their vasoregulatory capacity.
Their fecundity is significantly reduced.
Their formation is favored by mutations and external factors , such as heavy metals , pesticides , trauma-related oxidative stress and heat shock.
Their functionality therefore depends on a continuous lipid supply from the ER and the distribution of lipids between both mitochondrial membranes.
Their functional role is genomic stability maintenance.
Their functions could vary depending on the pathophysiological state of the tissues.
Their hair were exposed to Licatack , which is a recently developed new anti-louse medicinal product containing extracts of grapefruits besides high quality shampoo components.
Their handgrip strength and muscle strength of lower extremities were also measured using dynamometers.
Their hand skin temperature was measured before and after cold stimuli using infrared thermography.
Their health-seeking behaviour has been shown to be strongly influenced by family members and friends.
Their height , weight , and pubertal stage were recorded.
The IR-HGS association was not changed after further adjustment of leg strength.
Their high correlation with age makes them particularly applicable to represent the influence of aging onto skin mechanical properties.
Their higher propensity to develop serious adverse events and their shorter lifespan could prevent them from obtaining the potential benefits of the interventions administered.
Their horizontal disparity thresholds were a factor of ∼10 higher than adults , but their vertical disparity thresholds differed by a factor of only ∼4.
Their identified need for a greater response from the healthcare system should be tested in quality improvement programs for this overlooked yet rapidly growing population.
Their impact in the U.S. general population is however uncertain.
Their impact on the organoleptic perception of red wine is poorly known.
Their impact on the risk of thromboembolic events is well documented , with better results than those obtained with new oral anticoagulants.
Their importance should be constantly emphasized during the educational process of all kinds of health-care professionals as well.
Their incidence increases with age and might be a contributing factor to late-onset pathologies of the retinal vasculature.
Their individual rejuvenation would require specific surgical treatments according to their particular demands.
Their inhibition is a promising strategy for the treatment of several pathologies including cancer , atherosclerosis , hypercholesterolaemia , and infectious diseases.
Their involvement in two organs , blood and skin , is well documented.
Their Left ears showed worse results , in the competitive condition of SSW.
Their length is considered a marker of human replicative senescence and premature aging.
Their lengths of stay , mode of discharge and discharge management as well as costs and reimbursements according to the relevant diagnosis-related groups were analysed.
Their loss of functionality may indeed contribute to the development of aging and age-related neurodegenerative disorders.
Their mean ages were @number@ ± @number@ and @number@ ± @number@ years old respectively.
Their mean age was @number@ ( ± @number@ ) years , and most ( @percent@ ) worked in professional or managerial jobs.
Their mean age was @number@ years.
Their mean age was @number@ years and mean body mass index ( BMI ) was @number@ kg / m ( @number@ ) .
Their mean age was @number@ years and @percent@ were female.
Their mean FMD was @number@.6±2.3%.
Their mean length of stay was @number@ ( median , @number@ ) , range , 1-129 days.
Their mean ( SD ) age was @number@ ( @number@ ) years , and @percent@ ( n = @number@ ) were female.
Their median age was @number@ years and there was male predominance.
Their mobilization in germline but also some somatic tissues contributes to human genetic diversity and to diseases , such as cancer.
Their mortality risk , therefore , increased in the long-term perspective.
Their MRI features were similar to gliotic CMIs with or without cavitation , but these ' CMI mimics ' were always located juxtacortically.
Their multi-organ characters and their sensitivity for chemicals and environmental changes make them useful as in vivo toxicological and lifespan models.
Their needs will become an ever more dominant feature of public policy and healthcare provision.
Their nephroprotective activity could involve not only eNOS-dependent , but also NO-dependent but eNOS-independent mechanisms , or other molecular alternative signaling systems.
Their network composition was more heavily kin oriented ( @percent@ ) .
Their neuroprotective potential has been shown in both oxidative stress-induced and amyloid-beta and alpha-synuclein-induced neuronal death models.
Their occurrence in chronic hepatitis C ( CHC ) remains unclear , and triggering factors have to be elucidated.
Their older colleagues may be challenged and threatened by the new order.
Their ontogenetic development , phylogenetic evolution and aging changes are described.
Their oral health status may be jeopardised by frailty , disability , care dependency and limited access to professional oral health care.
Their origin and function are unknown.
Their OS was comparable to wild-type cases ( @number@ vs. @number@ months ) .
Their overall mean hs-cTnT level was @number@ ng / mL.
The IRP appears to identify a subset of treated HIV-infected individuals with a higher degree of immune senescence.
Their perceptions of and behaviors toward pain were often influenced by perceptions of their aging bodies.
Their performance change was compared with that of a control group.
Their performance was compared with that of @number@ young adults ( aged 18-28 ) .
Their peripheral blood T lymphocyte subsets and content of serum immunoglobin is detected before and two weeks after drug use.
Their preference for variation differs from those with a good appetite.
Their presence or absence makes possible or not the initiation of this commitment and its pursuit.
Their principal applications and their possible impact are discussed.
Their prophylactic use by healthy subjects to ameliorate stress and prevent age-related diseases appears to be justified.
Their proposal suggests that cognitive load differentially affects cognitive abilities in older adults.
Their proximal femoral bone mineral densities ( BMD ) were measured by quantitative computed tomography and further analyzed geometric properties.
Their QOL ( in its overall and physical , psychological , social and environmental domains ) was assessed with the World Health Organisation's WHOQOL-BREF.
Their QOL was more strongly related to severe depressive symptoms , major medical conditions , and insomnia.
Their qualifications are the 1st cycle of basic education ( four years of Primary School ) and have a predominance of cerebrovascular diseases.
Their reasoning in responding to these dilemmas reflected an ethic of care and responsibility and a recognition of the limitations of autonomy.
Their redox-regulated biosynthesis triggers in turn plant cell antioxidant and detoxification molecular mechanisms resembling human cell pathways.
Their regenerative potential is impaired by cellular senescence.
Their regular use may contribute to an understanding of the nutritional basis for the French Paradox.
Their rehabilitation is therefore of great importance.
Their relatively independent coping with requirements of routine activities is strongly determined by overall cognitive performance.
Their research has continued relevance to contemporary gerontological scholarship and practice , signaling both prevailing and emergent agendas for anthropologically informed gerontology.
Their respective share varied according to care.
Their results are promising but require further study.
Their results demonstrated that the relationship between confidence and error correction was stronger for younger adults compared with older adults.
The irreversible inhibition of acetylcholinesterase ( AChE ) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment.
The irreversible protein-protein interactions lead to protein aggregation and cell degeneration , which are observed in all aging-associated diseases.
Their role in the skin moisturization is completed by corneodesmosomes and tight junctions.
The iRR sequence was collected during ten minutes , breathing spontaneously , in supine position and in the morning , using a heart rate monitor.
Their scores were compared to those obtained by people of similar age without limitations ( general population ) .
Their serum IgE level was less than @number@ IU / ml.
Their shortening is caused by inflammation and oxidative stress within the cellular environment and ultimately leads to cellular senescence.
Their significance lies in their general good absorption and slow excretion within our body.
Their skin diseases were recorded and the distribution pattern was compared with those in the other studies.
The IRs of AMI during the 10-year follow-up period were compared among groups.
Their structures were elucidated by spectroscopic analysis , X-ray diffraction , and density functional theory calculations.
Their structures were elucidated on the basis of extensive spectroscopic analysis.
Their task was to determine whether the prime and test words were semantically related.
Their testes showed degeneration of seminiferous tubules , meiotic arrest before pachytene stage with incomplete meiotic recombination , induction of p53 , and enhanced apoptosis.
Their total testosterone ( TT ) levels were measured and carotid-femoral pulse wave velocity ( PWVc-f ) was measured as an index of aortic stiffness.
Their trabecular BV / TV also predicted their mothers ' cortical thickness ( r = @number@ p = @number@ ) .
Their transcriptional activity is regulated through a number of posttranslational modifications , including phosphorylation , acetylation and ubiquitination.
Their treatment is not only technically demanding and challenging , but can also be associated with serious complications.
Their underlying mechanisms , however , remain largely unknown.
Their unique role in energy supply makes these organelles essential , especially in those tissues strictly dependent on oxidative metabolism.
Their upregulation in diseased cardiovascular tissues and resistance to desensitization suggest they may be attractive therapeutic targets.
Their use as soft biomaterials and their related applications are described in this Review.
Their utility as predictors of geriatric trauma outcomes is unknown.
The IRVDI is a convenient tool for the selection of older people at risk for vitamin D insufficiency.
Their visits were characterized by higher emergency levels , admission rate and length of ED stay.
Their VO ( 2max ) was determined using incremental cycling exercise ( ICE ) .
Their WMH scores were rated using the CREDOS WMH visual rating scale.
The ISAR showed low to moderate sensitivity ( 54%-69% ) and a high negative predictive value ( ≥78% ) at all measurement points.
The ISAR , TRST and VIP were administered at admission.
The ISD failed to show an acceptable level of diagnostic accuracy for MCI ( AUC = @number@ ) .
The islet mass was significantly reduced in the eT2DM group.
The isoflavone genistein binds to estrogen receptor β and has been reported to improve skin changes.
The isolated neck lift is one the most common procedures requested by men asking for neck improvement.
The isolation of the pure monoculture should be performed using the antibodies against CD105.
The isolation paradigm is the classic method for studying the effects of distinctiveness on memory ( Hunt , @number@ ) .
The I-SPY @date@ neoadjuvant trials exemplify this approach.
The I-SSST is similar to the TSST but with a new twist : public singing.
The issue deals with the actual problem of gerontology , notably physiological features of human skin ageing.
The issue is divided into three main areas.
The issue of addiction to sildenafil is outlined.
The issues discussed are also relevant to the wider geriatric refugee or prisoner-of-war experience.
The issues of rising numbers of disasters , overwhelming increases in number of older adults , and historically flawed evacuations present real challenges.
The issues revealed in this study may be useful for adapting AAS for use in older community-dwelling adults.
The Italian Longitudinal Study on Aging ( ILSA ) included a prevalence phase in @number@ and an incidence phase from @number@ to @number@
The item hierarchy formed through logits provided an expected pattern of healthy lifestyle behaviors.
The items assessing machine control usability received the least favorable ratings.
The items fall across @number@ categories of function , movement , cognition and communication , social life , nutrition , and clinical symptoms.
The items not significantly related to the MNA global score were those concerning protein intake , independence and number of medicinal drugs taken.
The IVDs were carefully excised along with EPs and then sectioned to obtain midsagittal samples for macroscopic examination according to a five-grade classification system.
The iVolmin and iVolmax increased by @number@ and @number@ ml per decade , respectively , while LAAEF decreased by @percent@ per decade in both sexes.
The JAAM established a committee to promote the ER-type model of EM in @number@
The Jadad scale appraised the quality of identified studies.
The JAK2V617F allele burden was similar in patients with ( @number@ ± @percent@ ) and without ( @number@ ± @percent@ ) long-term hydroxyurea treatment.
The JAK2V617F mutation was searched and its allele burden was evaluated.
The Jamar hand dynamometer is the most widely used instrument with established test-retest , inter-rater and intra-rater reliability.
The Japanese Association for Acute Medicine ( JAAM ) , an academic society for emergency physicians , was founded in @number@
The Japanese Guidelines for VTE Prophylaxis were formulated and issued in @number@ and then revised in @number@
The Japanese population is rapidly aging and will have the largest proportion of elderly people in the world.
The Japanese sample was more likely to report historical events.
The Japan Hawaii Cancer Study provides data on incident cancer cases in the HHP / HAAS cohort.
The jaw opening force ( JOF ) was measured with a jaw opening sthenometer and compared between the healthy adult and elderly groups.
The JNK1-SIRT1 pathway provides a new molecular mechanism for the pathogenesis of hepatic steatosis in obesity.
The JOF of the men was significantly greater than that of the women in the healthy adult and elderly groups.
The joggers were divided into light , moderate , and strenuous joggers.
The Johnson-Neyman technique determined whether baseline IGF-1 levels moderated the relationship between changes in aerobic endurance ( Δ2MST ) and cognition ( Δ3MS ) .
The joint attention condition includes three types of social input : language , face-to-face interaction , and the presence of joint attention.
The joint attention condition involves an experimenter directing the infant's attention to pictures.
The joint effect of two exposures was quantified using the concept of relative excessive risk due to interaction ( RERI ) .
The joint kinematics , the stress distribution and resultant force of the ACL were obtained under a tibial varus or valgus torque load.
The jojoba plant produces esters of long-chain alcohols and fatty acids ( waxes ) as a seed lipid energy reserve.
The Journal of the American Medical Association , @number@ 2601-2608 ) , CGGT versus.
The Juvéderm product line exploits innovative 3-D technology , producing a range of cohesive , homogenous gels that produce predictable , long-lasting and natural results.
The Jyväskylä Longitudinal Study of Personality and Social Development ( n = @number@ ) follows individuals from age @number@ ( b.
The Kaplan-Meier curves of recurrence-free survival rates demonstrated that patients aged 55-64 had been continuously tumor-free than the equal or older than @number@ group.
The Kaplan-Meier method and Cox proportional hazards regression were used to examine the association between polypharmacy status and mortality.
The kappa coefficients for intraobserver and interobserver agreements were substantial to excellent ( intraobserver [ @number@ ] and interobserver [ @number@.721 0.807 ] ) .
The Kato-Katz technique is the most widely used diagnostic method in epidemiologic surveys and drug efficacy trials pertaining to intestinal schistosomiasis and soil-transmitted helminthiasis.
The Katz Index of Independence in Activities of Daily Living ( Katz ADL ) was used to assess functional status.
The KCNJ11 I337V gene polymorphism was determined using high-throughput TaqMan technology.
The KCT problem is NP-hard , and existing solution approaches are mostly heuristic.
The KDIGO definition of chronic kidney disease ( CKD ) allowed a more detailed characterization of CKD causes , epidemiology and consequences.
The KEAP1-Nrf2-ARE antioxidant system is a principal means by which cells respond to oxidative and xenobiotic stresses.
The key event caused by WRN gene mutation is the dysfunction of telomeres.
The key features of JBBNNR are as follows.
The key finding of our study was that SIRT1 expression plays a pivotal role in the telomere-mitochondrial interactome.
The key informants ( n = 35 ) were randomly selected nutrition managers of Ontario LTC homes.
The key is damage of sensory cells of the retina and inner ear caused by microcirculatory disorders.
The key issue is whether further evaluations are warranted to extrapolate the results in a clinical setting.
The key lipid-lowering target is to achieve guideline-recommended low-density lipoprotein cholesterol ( LDL-C ) levels , usually by using statins.
The key management decision is whether to add radiotherapy and / or endocrine therapy to minimize the risk of a subsequent recurrence.
The key might be found in high-quality care in the community.
The key molecule involved in skin moisture is hyaluronic acid ( HA ) , which has a significant water-binding capacity.
The key role of ERK signaling was shown by reduced nuclear accumulation of phosphoERK and of ELK-1 phosphorylation in response to CF.
The key safety endpoint was type @number@ @number@ or @number@ bleeding according to the BARC criteria.
The key secondary endpoint was satisfactory relief of overall IBS symptoms.
The key stakeholders drafted evidence-based policy recommendations that were used to develop policy briefs.
The key variables in these models are usually measured by using psychometric instruments.
The keywords used in the search were \ "Higashi Nihon Dai-shinsai \ " ( The Great East Japan Earthquake ) .
The keywords used were : benign prostatic hyperplasia ; cyclic nucleotide phosphodiesterase type @number@ lower urinary tract symptoms ; erectile dysfunction.
The key words used were words that described meal time assistance for adult patients in hospital units or rehabilitation settings.
The Kidney Disease Outcomes Quality Initiative chronic kidney disease ( CKD ) classification was used to categorize patients ' eGFR values.
The kidney was innately larger than that of control mice with no histological alterations.
The kinase activity of mTOR is controlled by upstream regulatory proteins and its subcellular localization.
The kind of resources used postdischarge also varied between treatment groups.
The kinematic differences were identified for middle-aged as well as older adults suggesting midlife changes in neuromuscular physiology or behavior may have important consequences.
The kinematic performance of basic motor tasks shows a clear decrease with advancing age.
The kinetic experiments showed no reactivation of activity.
The kinetics changes of activated γδ T cells were much stronger in the young , while corresponding changes in the elderly occurred slower.
The kinetics of DSB-induced chromatin association of CSB is distinct from that of its UV-induced chromatin association.
The kinetics of evolution of each test variable were distinct over time.
The kinetics of the assay where the cell's PT response transforms from linear to nonlinear regime is reported.
The kinetics of water movement through the SC is also decreased.
The Kitchen Picture Test ( KPT ) is a new screening measure of practical judgment.
The KIT-ET3-NO pathway most likely also play critical roles in other cell functions that involve dual requirement of SCF-KIT signaling and NO.
The Klotho gene encodes a transmembrane protein that after cleavage is also found as a secreted protein.
The Klotho gene , identified as an ' aging suppressor ' gene , encodes a single-pass transmembrane protein.
The Klotho gene is a suppressor of the aging phenomena , and the secretion as well as the circulation of Klotho proteins decrease with aging.
The Klotho gene is closely related to this pathway.
The Klotho gene was identified as an ' aging suppressor ' in mice.
The klotho mouse shows a phenotype , regulated by only one gene named α-klotho , similar to human progeria.
The Klotho protein deficiency is known to participate in premature aging.
The Klotho protein exists in two forms , a full-length membrane form and a soluble secreted form.
The Klotho protein not only serves as a coreceptor for FGF-23 , but also functions as a humoral factor.
The KL-VS heterozygote survival and white matter volume disadvantages were unexpected.
The KLVS polymorphism is suggested to lead to changes in protein trafficking although the mechanism is unclear.
The KL-VS variant did not have any influence on plasma NO ( x ) status ( p = 0.260 ) .
The K ( m ) values for nicotinamide are low and in the range of @number@ @number@ μM.
The knee extension force in the sitting position and thickness of the quadriceps femoris muscle were also measured.
The knee joint was @number@ cm posterior and the ankle joint was @number@ cm posterior to the GL.
The knockdown of these three FOXOs by siRNAs completely abolished the SOD2 induction , ROS reduction , and anti-apoptotic function of resveratrol.
The knowledgebase was extensively populated with literature-derived data using text mining techniques.
The knowledge level toward LST was assessed and compared before and after the presentation of the two vignettes.
The knowledge of age related changes in spinal features are important in understanding different spine related problems.
The knowledge of general vibratory characteristics and gender difference is beneficial for the appropriate clinical care of VFA.
The knowledge of the burden of chronic musculoskeletal disorders in elders is still limited , particularly in the developing world.
The knowledge on that phenomenon develops towards an integrative approach.
The knowledge on the molecular aspects regulating ageing in eukaryotic organisms has benefitted greatly from studies using the budding yeast Saccharomyces cerevisiae.
The knowledge translation tool was acceptable and usable , but further evaluation is required.
The kojic acid ( KA ) is iron chelator employed in treatment of skin aging , and inhibits tyrosinase , promotes depigmentation.
The KOP-Q is developed and validated in the Netherlands.
The Korean Longitudinal Study of Aging was utilized to analyze data from @number@ women over @number@
The Korean National Health Insurance Service Senior Cohort Database contains personal medical data of every citizen in Korea.
The Korean versions of the Patient Health Questionnaire ( PHQ-9K ) and Mini-mental Status Examination ( MMSE-KC ) were administered by trained community health workers.
The KRAS GTPase plays a critical role in the control of cellular growth.
The Kreuth initiative toward optimal use of blood products should continue.
The Kruskal-Wallis nonparametric test was used to determine intergroup difference.
The L1 slope is a central parameter that defines the whole-spine sagittal balance.
The L5- and CBS-offset in subjects in their 50s and 60s were also significantly posterior to those in subjects in their 30s.
The LAA isthmus is considerably shorter than the mitral isthmus.
The LAA isthmus line was smooth in @percent@ of all cases , with only small crevices in the remaining @percent@.
The LAA isthmus was longer in hearts with a common left pulmonary vein ( p = .037 ) .
The label distribution covers a certain number of class labels , representing the degree that each label describes the instance.
The labels did not increase educational inequalities among continuing smokers.
The laboratory data of patients were collected and the telomere length parameters in their peripheral blood leukocytes were determined by Southern blotting.
The laboratory data suggested that the disease status was uncontrolled to a greater extent , and complications were more common in the elderly group.
The laboratory model did not reflect the clinical findings.
The lack of a formal definition of human longevity continues to generate confusion about its genetic and nongenetic determinants.
The lack of age-related decrease in non-visual sensitivity to light may involve as yet undefined adaptive mechanisms.
The lack of any clear association supports the conclusion that ALS is likely to be caused by multiple rare genetic risk factors.
The lack of any major involvement of DNA-PKcs in NHEJ in hESCs was supported by siRNA-mediated DNA-PKcs knockdown.
The lack of apparent clinical benefit merits further investigations in patients with reduced cardiac performance.
The lack of association between the genetic score and the latter phenotypes also was observed in the Women's Genome Health Study.
The lack of associations between weight gain and cognition in women is consistent with the existing literature.
The lack of association with ECG derived QTd and UCP2 DD may suggest that gene-related QRS duration prolongation is independent of cardiac hypertrophy.
The lack of a unified definition for SO might contribute to inconsistent findings about the association of SO with CMD.
The lack of change between the low and high demanding tasks suggests that elderly reach a resource ceiling.
The lack of consistent improvements in walking kinematics is attributed to the presence of multiple disabilities and limitations present in the frail subjects.
The lack of data on risk benefit ratios may result in challenging clinical decisions in this expanding group of patients.
The lack of data on vitamin D and bone health outcomes in certain population groups such as diverse racial groups warrants attention.
The lack of diagnostic criteria to identify patients with sarcopenia hinders potential management options.
The lack of evolutionary established mechanisms linking genes to age-related traits makes the problem of genetic susceptibility to health span inherently complex.
The lack of exercise has been linked to increasing the incidence of hypertension , coronary artery disease , osteoporosis , degenerative arthritis , and diabetes.
The lack of invariance in item @number@ confirms previous studies with adults and emerging adults in Chile that suggest this item is culture-sensitive.
The lack of sensitive , standardized MV assays , however , poses a significant barrier to implementing MV analyses into clinical settings.
The lack of specificity of the clinical presentation of hypothyroidism in the elderly might justify the routine measurement of thyroid-stimulating hormone in these patients.
The lack of such reference intervals may imply significant risks for the patients.
The lack of theory-driven , systematic approaches and ( occasionally serious ) methodological shortcomings complicates this debate even more.
The lack of this modification directs BACE1 to late endosomes / lysosomes where it is less colocalized with APP , leading to accelerated lysosomal degradation.
The lack of validation studies of previous results prompted us to replicate this finding in a comprehensive series of patients and controls.
The lactulose mannitol ( LM ) dual sugar permeability test is the most commonly used test of environmental enteropathy in developing countries.
The LA distensibility , which demonstrates LA reservoir function , decreased with age and BSA.
The lag could be chosen as the first minimum of the auto mutual information function.
The lamellar structure of the vitreous cortex may be related to the vitreoschisis.
The lamellar structure of the vitreous cortex was seen in @number@ of the @number@ eyes ( @percent@ ) of subjects aged > 51 years.
The lamina is an important regulator of nuclear structural integrity as well as nuclear processes , including transcription , DNA replication and chromatin remodeling.
The lamina provides mechanical support for the nucleus and functions as the major determinant of its size and shape.
The lamin A tail was unique among lamins in having a second actin-binding site ( AB-2 ) .
The Lamtor2 : Lamtor3 dimer stacks upon Lamtor4 : Lamtor5 to create a platform for Rag binding.
The language barrier , low education and cultural differences make the diagnosis more difficult.
The language was restricted to English.
The large cells were positive when tested by Epstein-Barr virus ( EBV ) -encoded RNA in situ hybridization.
The large majority of the deregulated transcripts were expressed by Sertoli cells ( SCs ) and Leydig cells ( LCs ) .
The large number of cases , including some very rare conditions , provides a unique resource and an opportunity for worldwide collaborations.
The large number of people over @number@ years of age , and their difficult living conditions , underline the importance of informal caregivers.
The large number of possible causes and their interaction shows why it is so difficult to mitigate anemia prevalence.
The large-particle variant may have longer persistence that may be useful in selected clinical circumstances.
The large population will continue to increase because of baby boomers that have recently turned @number@ years old.
The larger dosage produced severe brain injuries as well as neurological deficits , more closely mimicking severe human ISH.
The larger dosage , therefore , would be useful for investigating the pathophysiology of the severer ISH in the striatum.
The larger ooplasmic volume was also associated with earlier and more rapid cleavage ( p < @number@ ) .
The larger the underlying WFE , the greater the impact on measurement variation.
The larger the WFE and pupil center uncertainty , the greater the effect.
The largest challenge to be addressed is the delegation of physician tasks to physician assistants.
The largest components of costs included the management of prevalent type @number@ diabetes and incident cardiovascular events.
The largest decline occurred on entering the labor market ( from @percent@ to @percent@ ) .
The largest differences were in basal ganglia , and frontotemporal and limbic regions , with sparing of parieto-occipital regions.
The largest hip torque found was the trail-limb hip extensor torque.
The largest increase in body weight and BMI ( mean @number@ ) was recorded among female primary care physicians.
The largest indel ( p.Gly138 Tyr143del ) was observed in @number@ control.
The largest number of diseases ( @percent@ in men and @percent@ in women ) was identified during seeking medical assistance in polyclinic.
The largest overall decrease is observed in N2 with @number@ per decade.
The largest proportion ( @percent@ ; n = @number@ @number@ ) were between @number@ and @number@ years of age.
The largest relationships linked FA and striatum volume to processing speed and executive function , and hippocampal volume to episodic memory.
The largest reported improvements were in their ability to educate patients and caregivers about dementia and making appropriate referrals to community care services.
The largest retention was in knee extensor strength but most of the exercise effects were lost in the follow-up.
The largest seasonal changes were obtained in BFV in carotid arteries , the relative constancy in BFV in the basilar artery.
The largest trial is a @number@ patients observational series that confirmed the role of CGA in decision making.
The largest variation was observed in overall functioning ( Cohen's d = @number@ ) .
The large total contraction time may be related to muscle hypertrophy and strength gain.
The large variation in progression measures , comorbidity indexes and study designs hampered the ability to perform a meta-analysis.
The large width of @percent@ confidence interval ( CI ) for a new prediction suggests questionable reliability for clinical use.
The LASA cohort is a representative sample of the Dutch older population.
The laser gradually lightened the skin tone and macula and was ultimately more efficient than the IPL after five treatments.
The laser needs a power adaptation to meet the set fluence per microbeam.
The laser operates in wavelength from @number@ to @number@ nm.
The laser toning regimens received by these patients , as well as the treatment given for depigmentation , were analyzed retrospectively.
The laser was well tolerated by all patients with no adverse effects.
The last age group included @number@ participants , totaling @number@ males.
The last date of examination was @date@ .
The last decade has witnessed the development and characterization of tracers for the evaluation of neuropathology in vivo.
The last decade , however , has seen substantial changes in our conceptions of this increasingly recognized disorder.
The last factor increases bone density at puberty , mostly due to estrogen production.
The last @number@ years have been characterised by an increase in life expectancy and an improvement in the quality of patients ' lives.
The last section of the manuscript is devoted to the age-associated diseases in which exercise is contraindicated.
The last two decades have seen a revolution in these prevailing dogmas , with a significant contribution made by the authors.
The Latarjet procedure is one of the most common procedures performed.
The late activation of GR had a similar gene-expression profile as from GR pre-activation , while ameliorating the disruption of metabolic genes.
The late form can occur in old age with psychosis , paranoid delusions , affective disorders or cognitive impairment.
The latencies for the wrist , elbow , and shoulder displacements were @number@ ± @number@ @number@ ± @number@ and @number@ ± @number@ ms , respectively.
The latency shift for the probe response relative to the masker response was calculated.
The latent class analysis classified four groups of the elderly individuals according to their lay views on successful aging.
The latent health dimension represented somatic health , and was tested against three external criteria : height , waist-hip ratio , and smoking status.
The late onset patients showed a distributed bilateral pattern with the temporal and cingulate areas strongly affected.
The late P2 and N2 to novels inversely correlated.
The lateral brow was higher than the middle brow with a mean height of @number@ mm ( 0-4.2 mm ) .
The lateral curvature of the femoral shaft associated with aging may contribute to the initiation of varus-type OA of the knee.
The lateralization-by-age interaction was not significant for movement execution.
The lateral ventricles were manually extracted by an experienced neuroradiologist on b ( @number@ ) images.
The later born cohort showed steeper mortality-related declines.
The later group includes the stem cells existing in both embryo's and adult human's organs.
The latest approach to the research on therapeutic utility of reminiscence is gaining popularity among researchers and practitioners , and has yielded promising results.
The latest classification proposed by The Cancer Genomic Atlas ( TCGA ) , has been made routinely applicable through the international consortium TransPORTEC.
The latest generation of smartphones is comparable to computers , allowing the development of new applications in health field.
The latest insights into molecular mechanisms of autophagy lead to the discovery of potential drug targets.
The latest replicator dynamics models assume that regulation of the population size acts through feedback driven by density dependent juvenile mortality.
The latest studies have shown that the level of circulating GDF @number@ correlates with the outcomes of patients with cardiovascular diseases , cancer and uremia.
The latter also had significantly lower C-reactive protein levels , indicating a lower proinflammatory status compared with CMV-infected controls.
The latter appear to be mainly the consequence of injury , strain and aging in a predisposing genetic background.
The latter are enriched in echinocytes and other misshapen cells during storage.
The latter are often in need of a comprehensive geriatric assessment ( CGA ) .
The latter association might be an epiphenomenon of regression to the mean.
The latter compared well with a measured thickness increase of @percent@.
The latter compounds look promising in treating several incurable pathologies as well as aging.
The latter comprise eight signs , among the @number@ that became , far above scoring threshold , indeed affected during this 6-month period.
The latter effects interact to produce the most severe phenotype in old Scn5a ( + / - ) mice.
The latter finding provides a clue for countering age-related decline in physical activity.
The latter findings imply that both components were involved in the observed group differences in the variability of force fluctuations in the modulation task.
The latter form of molecular regulation is probably the least studied.
The latter form suppresses oxidative stress and growth factor signaling and regulates ion channels and transporters.
The latter gene encodes for a small ( @number@ amino-acid ) subunit and appeared important for the stabilization of the entire TFIIH complex.
The latter group had a higher prevalence of ischemic heart disease and low walking speed.
The latter group rated their depression symptoms the lowest.
The latter had almost non-existent levels of FVIII : C and extremely prolonged aPTT , with otherwise normal hematologic parameters.
The latter harbor the ortholog of the most frequently encountered human R350P desmin missense mutation.
The latter has been determined experimentally.
The latter has features of SASP ( senescence-associated secretory phenotype ) , whose protumorigenic properties are potentiated by YAP , PML and p53 depletion.
The latter has received the greatest attention because of its reported potential for an allergic response.
The latter include more focused educational activities at the undergraduate and graduate levels and continuous clinical training throughout their work as palliative care nurse specialists.
The latter includes deterioration of the material and structural properties of bone.
The latter includes deterioration of the material and structural properties of bone.
The latter is a novel finding and was confirmed by a direct survey of female BPPV patients ( @number@ participated ) .
The latter is critical for transparency , but the mechanism by which cell nuclei are removed has remained an age old enigma.
The latter is illustrated by a 2-4-fold increase in the levels C-reactive protein ( CRP ) or interleukin ( IL ) -6.
The latter is primarily attributable to attenuation of the orbitomalar ligament.
The latter may underscore a tight link between SIRT1 and insulin signaling components.
The latter melted and liquefied the organic and synthetic components of the granulomas , facilitating subsequent evacuation.
The latter might occur in a proteoglycan depleted peri-cellular matrix , where DDR-2 expression is enhanced in OA cartilage and transgenic suppression attenuates experimental OA.
The latter part of the 20th century was a period characterized by a fundamental transition in scholarship on activity and the aging process.
The latter received meropenem according to a regimen decided by the attending physician.
The latter received supervised modified step aerobics training ( twice weekly , @number@ h per session ) over a period of @number@ months.
The latter represents the proportion of total biomarker variance accounted for by the between-individual variance.
The latter results have led to inferences that cognitive change does not begin until late middle age.
The latter result should be further evaluated in future studies.
The latter supports the hypothesis that senescence-specific de-repression of SPP1 aids in SIPS-dependent stromal activation.
The latter two genes are candidate genes for risk for sporadic PD identified by genome-wide association studies.
The latter two , together with albumin and fibrinogen , aligned with an \ "integrated albunemia \ " model of aging proposed recently.
The latter underline the compensatory processes of normal typical and pathological aging.
The latter was derived from @number@ CRC cases diagnosed in the German screening colonoscopy program during 2003-2007.
The latter was due to a @percent@ increase in IDL-apoB FCR coupled with a @percent@ decrease in conversion of IDL to LDL.
The latter was initially deemed to be a missense mutation but we demonstrate here that it affects splicing.
The latter were also inversely related to elevated CRP and positively associated with hyperuricemia.
The latter were regionally specific depending on their differential sensitivity to microscopic tissue properties.
The LAVs measured by RT3DE were significantly smaller than those measured by the 2D biplane Simpson's method.
The law decree no.
The law in most countries requires the healthcare provider to persist the records for a certain amount of time.
The layered system skin / sWAT appears as the hierarchical structural composite in which single layers behave as fiber-reinforced structures.
The layout of the PILs was evaluated using criteria derived from the relevant regulatory guidelines on the design of PILs.
The LCC-derived CM was found to be more potent than fibroblast-derived CMs and , furthermore , to inhibit alpha-smooth muscle actin expression.
The LC-MS / MS conditions in the presence of sodium , and the extraction method using methanol protein precipitation were optimized.
The LD ( @number@ ) in @number@ h was @number@ × 10 ( @number@ ) cells / mL.
The leading classes of medications identified to cause PIMs were those acting on the central nervous system ( @percent@ ) .
The leading discipline in the study of aging ( within the humanities ) is sociology accounting for more than a third of all defended theses.
The leading joint hypothesis ( LJH ) offers a novel interpretation of control of human movements that involve multiple joints.
The leading tonal marker was always a 20-ms , 250-Hz complex tone with energy at @number@ @number@ @number@ and @number@ Hz.
The lead variants in @number@ of these loci had a high probability of being causal.
The lean mass of the thigh was measured by dual-energy X-ray absorptiometry.
The learning difficulty ordering for these types of three-dimensional stimuli has proven robust and has been replicated by several researchers.
The least commonly occurring everyday activities were going to the cinema , participating in an educational program , visiting a restaurant and doing everyday chores.
The least effective recruitment strategy was the use of flyers , which resulted in only @number@ completed interviews or questionnaires.
The least-effective vaccine currently recommended is the varicella-zoster vaccine , with a @percent@ efficacy.
The least frail group consisted of @number@ participants , corresponding with @percent@ of the study population.
The least frail group was selected based on a frailty index score ≤ @number@
The least frail group was significantly younger , had less severe levels of ID , and less often Down syndrome than the remaining group.
The least frequently encountered were the representatives of asthenic ( @percent@ ) and athletic ( @percent@ ) somatic types.
The least prevalent type was the fully restricted network type ( @percent@ ) .
The left arms were also treated with EGF through a tip.
The left LC showed strong connectivity to the left parahippocampal gyrus that correlated with memory performance in healthy persons.
The left LF at the L4-L5 and L5-S1 levels was significantly thicker than on the right side ( P < @number@ ) .
The left side of the face served as the control side.
The left ventricle was partially involved in RT fields in all patients.
The leftward shift in both young and older subjects ' estimates was in the same direction and a third of the extent of adapted movement.
The legal context is described.
The leg strength loading was significantly greater than the fat mass loading in men and women aged 55-64 and ≥ @number@ and differed between sexes.
The length from the aortic valve to the major reflection site ( eg , effective reflecting length ) significantly increased with aging.
The length of catheter introduction ranged from @number@ to @number@ cm.
The length of hospitalization stay was also longer in seniors ( @number@ days ) than other adults ( @number@ days ) .
The length of hospital stay was calculated in number of days using the hospital registry.
The length of pharynx was associated with gender and age.
The length of stay in the ICU was also significantly shorter in NIV group ( @number@.2±4.9 vs. @number@.7±7.7 days ) .
The length of surgical incision was @number@ cm.
The length of telomere repeats and the integrity of telomere-binding proteins are both important for telomere protection.
The length of the body , the transverse diameter of the chest and the cerebellar mass were measured.
The length of the critical noun phrase ( NP ) as well as the type of verb provided were manipulated.
The length of the telomeric arrays in fishes ranges from @number@ to @number@ kb and shortens with age in some of the species.
The length , width , and surface area of the footprints were measured.
The lens absorption of each subject was also estimated using a heterochromatic flicker photometry ( HFP ) paradigm.
The lens grows and becomes cataractous.
The Lens Opacities Classification System III was used to grade the cataracts at baseline.
The less frequently registered were the groups of infectious disease , injuries and ear diseases.
The lethality rate was @percent@.
The level and the location of the maximum intensity of sources also differed between genders , especially in young subjects.
The level of accompanying comorbidities in Group-1 was significantly lower than that of the other groups ( p = @number@ ) .
The level of activity of this histaminergic system in AD remained unknown.
The level of aggrecan mRNA was highest in the mature group and decreased significantly with aging.
The level of agreement across all three instruments was good ( Gwet's AC1 = 0.907 ) .
The level of agreement of these estimations was assessed by a Bland-Altman analysis.
The level of agreement was found to be lowest at baseline , and increased during follow-up visits.
The level of antioxidants contained in the majority of skin creams is not sufficient to majorly impact free radical damage.
The level of cognition in five different cognitive abilities was also related to incident mobility impairment.
The level of complexity and low financial compatibility emerged as the strongest potential inhibitors to program implementation in the context examined.
The level of distress on the DTE was significantly related to depression , number of problems and practical-physical problems.
The level of education of the girls is also a major factor.
The level of eNO among asthmatic children was higher than that of normal children in both the younger and the older groups.
The level of family-perceived distress was evaluated on a numerical rating scale from @number@ to @number@
The level of HMF in cooked butters was @number@ ± @number@ μg / g.
The level of insoluble Aβ rises with age and is further increased in AD.
The level of interest of participants for the DBox topics , and their level of satisfaction with the Dboxes demonstrate the acceptability of the intervention.
The level of matching between the item's difficulty and person's ability was analyzed by item-person targeting as well as ceiling and floor effects.
The level of MMP-1 mRNA increased with age and both type I , II collagens decreased with age.
The level of Ni was measured and the correlation coefficient was calculated.
The level of @number@ hydroxy vitamin D ( 25OHD ) was measured.
The level of oxidative stress to mitochondrial proteins is not constant , but instead varies greatly with numerous metabolic and environmental factors.
The level of pain is a major determinant for the outcome of any treatment of these fractures regardless of its location.
The level of perceived threat is likely to affect the proportion of nurses willing to work.
The level of physical activity may even be reduced to a minimum when physical restraints are applied.
The level of physical exercise was assessed using self-report form.
The level of responsiveness was strongly affected by the duration of the exercise intervention , with more positive responses following more prolonged exercise training.
The level of reverberation was varied to alter task difficulty by interfering with localization cues ( increasing localization blur ) .
The level of service is behind people's expectations.
The level of significance for all analyses was p < @number@
The level of significance for statistical tests was P < @number@
The level of significance was defined as P ≤ @number@
The level of significance was p < @number@
The level of significance was P ≤ @number@
The level of significance was set at P @number@
The level of statistical significance was set at P < @number@
The level of Svbp mRNA was relatively high in the bone marrow , spleen and testes of mice.
The level of tau protein deposition in the hypothalamus was compared semi-quantitatively with that in the posterior pituitary , and the levels correlated well.
The level of these hydrolyzable tannins in wine depends of some parameters of oak wood.
The level of total IgE followed a similar trend to that of allergic sensitization.
The level , size , and functionality of cutaneous HA are known to diminish with age.
The levels of acrolein , methacrolein , and acrylonitrile exceeded concentrations considered harmful by the State of California.
The levels of antioxidative enzymes , such as heme oxygenase @number@ and @number@ Cu / Zn-SOD , Mn-SOD and catalase , were also examined.
The levels of Cd and cotinine were adjusted for creatinine level.
The levels of C-PP and AP were much higher in those with a high AIX ( P = @number@ ) .
The levels of daily physical activities were also examined in all age groups.
The levels of DA in the cerebral cortex of both MHE and DA ( @number@ µg ) -treated rats were increased.
The levels of exosome-associated Aβ notably decreased in the CSF of aging animals.
The levels of H3K4-trimethylation and histone acetylation are also enriched at the HOTAIR promoter.
The levels of HDL-c in the longevity group were different among the three genotypes ( p < 0.05 ) .
The levels of hs-CRP increased in pilots as they presented greater numbers of MS diagnostic criteria.
The levels of human OGG1 protein , which is associated with mtDNA repair , were analyzed by Western blot.
The levels of IL1B and MMP13 mRNA were examined using qRT-PCR.
The levels of let-7a correlated inversely with the levels of Shc proteins without affecting Shc mRNA levels.
The levels of long-chain acyl-CoA esters decreased with increased passage number.
The levels of maximum curvature were at S3 and S2 in @percent@ and @percent@ of cases , respectively.
The levels of metabolic risk factors were positively associated with age , yet only few subjects fulfilled all metabolic syndrome criteria.
The levels of microRNAs ( miRNAs ) are altered under different conditions such as cancer , senescence , and aging.
The levels of microRNAs ( miRNAs ) could be altered during muscle maintenance and repair.
The levels of mRNAs of ho-1 , bach1 , and CD14 were measured by qRT-PCR.
The levels of oxidized proteins in plasma provide an excellent biomarker of oxidative stress due to the relative long half-life of such oxidized proteins.
The levels of p53 and p21 were elevated.
The levels of peripheral amyloid , Aβ40 and Aβ42 , are not modified in either sex until @number@ months of age.
The levels of PGRN were upregulated in murine IVD tissue during aging process.
The levels of plasma GDF11 were significantly positively correlated with pulmonary function data.
The levels of protection achieved were equivalent to those observed with irradiated sporozoites , a candidate vaccine undergoing development for further large scale clinical trial.
The levels of R for AD were significantly higher than those for DM2 or FTD.
The levels of several BTMs were determined , and the BMD was measured using a dual-energy X-ray absorptiometry.
The levels of the brain-derived neurotrophic factor ( BDNF ) were determined in hippocampus and frontal cortex of mice at 5months of age.
The levels of the serum BuChE and red blood cells acetylcholinesterase and the serum PAM levels were also measured.
The levels of thiamine and its derivatives of those with MetS were not significantly different from those without.
The levels were closely correlated with age in both normal controls and patients with asthma.
The levels were semi-quantitated by densitometry.
The levobunolol hydrochloride solution was discontinued and the bradycardia resolved.
The lexical effect on the F2 slope differed among the diphthongs and between the @number@ groups.
The LFA was measured as the cross-sectional area of the whole LF at the L4-L5 stenotic level.
The LF is an important anatomical structure , which might cause low back or leg pain.
The life expectancy for persons living with HIV infection is markedly increasing , largely because of the advances made with antiretroviral therapy.
The life expectancy of persons with Prader-Willi syndrome ( PWS ) has increased in recent years.
The life experiences , values , and attitudes shared by generations make a cohort-specific analysis of gambling among older adults a worthwhile pursuit.
The life of a patient so affected is prolonged by therapy with hormones , antimicrobials , and immunosuppressants.
The LIFE PA program may be an effective strategy for reducing mobility disability in vulnerable older persons with MetS.
The Life Review and Experiencing Form ( LREF ) structured the delivery of the life review component.
The Life-Space Assessment ( LSA ) , indicating distance and frequency of moving and assistance needed in moving ( range 0-120 ) , was used.
The lifespans in these @number@ groups were significantly shorter compared with normal controls ( @number@ ± @number@ days , both p < @number@ ) .
The life stories of @number@ older twins were analyzed with narrative analysis.
The lifestyle questionnaire was used to evaluate the data.
The lifetime CVD risk , up to age @number@ for men and women at age @number@ were @percent@ and @percent@ respectively.
The lifetime prevalence of ICDs was @percent@ in men and @percent@ in women.
The lifetime risk of cancer for people born since @number@ is forecast to be more than @percent@.
The lifetime risk was similar ( > 30% ) for both sexes.
The ligament limited the descent of the orbicularis oculi muscle.
The light device used did not lead to a considerable clinical improvement of hypertrophic scars , acne scars , or wrinkles in this study.
The likelihood of CJD was assessed using our previously published criteria.
The likelihood of having hypertension does not decrease during the PD course ; rather , BP pattern shifts towards nocturnal hypertension.
The likelihood of having short versus long telomeres was calculated as a function of stress and exercise group , covarying age , BMI and education.
The likelihood of multimorbidity was higher in older age groups and was lower in those with higher socioeconomic status.
The likelihood that FNBMD has improved appears strongest for older white women.
The likelihood that the geriatric LTC system must prepare for adequately caring for this population is high.
The likelihood that the mandibular cortex index agrees with adjusted PIXI T-values is significant.
The likely future of HZ burden is one of rising costs , primarily driven by the demographic shifts of an increasing and aging population.
The limitations of the research and recommendations for intervention are discussed.
The limited age range prevented meaningful interpretation of age effects on measured data or the automatic segmentation procedure.
The limited agreement may , in part , reflect differences in typical measurements of Aβ using imaging compared with the CERAD neuropathologic protocol.
The limited data from intervention trials provide some support for observational studies with regard to nuclear - but not other types of - cataracts.
The limited data on sodium thiosulfate are promising.
The limited durability of prosthetic cardiac valves together with an aging population will present ongoing management challenges.
The limited evidence does not allow conclusions to be drawn or to inform clinical practice.
The limited lifetime of prosthetic devices made from first-generation nearly inert biomaterials requires new approaches to meet these two large needs.
The limited number of studies meeting inclusion criteria warrants formulation of guidelines for reporting in clinico-pathological studies ; suggested guidelines are provided.
The limited previous research suggests that the absence of explicit terminology ( e.g. , use of the term Alzheimer's ) is problematic.
The limited research associating vitamin D , alcohol , dietary acid-base load , dietary fat and anti-oxidant nutrients with age-related muscle loss is described.
The limited research conducted so far on endocrine disruptors , aging , and neurogenesis argues that they should be overlooked no longer.
The limited role relates to a lack of reimbursement streams , which stems from poor articulation about their unique contributions.
The limiting factor for long-term graft survival is allograft vasculopathy , an immune-mediated process causing diffuse narrowing of the coronary arteries.
The limits of agreement were ±6.13 kg / m ( @number@ ) using KH and ±4.66 kg / m ( @number@ ) using UL.
The limits of the model were assessed by evaluating the impact of aging , cerebral damage and spatial deficits.
The linea aspera ( LA ) forms a characteristic ridge along the posterior aspect of the human femur.
The lineage-specified progenitors of ILC3s and their site of development after birth remain undefined.
The linear and logistic regression models results were both evidently worse than EANN results.
The linear and nonlinear dose-response relations were evaluated with data from categories of lycopene consumption / circulating concentrations.
The linear association of Cho ends at the age of about @number@ years and is followed by an inverted ' U'-shaped curve.
The linearity of signal and the methodological variation coefficient was obtained.
The linearized mortality rate was @number@.1% / patient-year ( porcine : @number@.9% / patient-year ; mechanical : @number@.2% / patient-year ) .
The linear multiple regression analysis confirmed that age and cigarette smoking had independent effects on plasma KL-6.
The line between Mn-dependent biology and toxicity is thus blurred.
The linkage of TR4 functions in cancer progression , however , remains unclear.
The linkage scan found a single significant linkage peak on chromosome @number@
The link between brain iron homeostasis and neurodegenerative disease has been the subject of extensive research.
The link between brain structure and intelligence is a well-investigated topic , but existing analyses have mainly focused on adult samples.
The link between cancer , cardiovascular disease , and aging is well documented.
The link between chronic sun exposure of human skin and harmful clinical consequences such as photo-aging and skin cancers is now indisputable.
The link between dietary phytochemicals and eye health is well established , although transition away from a wild diet has reduced phytochemical variety.
The link between HIF-1α and apoptosis , a major determinant of cancer progression and treatment outcome , is poorly understood.
The link between lower Openness and AD risk is consistent with recent findings on cognitive activity and AD risk.
The link between psychological stress and aging is intuitive although the underlying mechanisms are not well defined.
The link between reduction of hematoma growth and improved outcome is therefore still lacking.
The link between stroke and the later development of dementia is not understood.
The link between this bias and relative volume of the ACC suggests a shared mechanism with an age-related positivity bias.
The links between cellular and vascular ageing reflect a complex interaction between genetic and environmental factors acting over the life-course.
The links between hormonal signalling and lifespan have been well documented in a range of model organisms.
The link with past exposure among retirees decreased with age.
The lipid and apolipoprotein composition of HDL was severely altered and its beneficial functions were severely diminished.
The lipid composition of myelin varies significantly from other biological membranes.
The lipid to protein ratio and lipid compactness decrease significantly with age only for the arm sites.
The Lipocalins ApoD , Glial Lazarillo ( GLaz ) and Neural Lazarillo ( NLaz ) are neuroprotectors upon oxidative stress or aging.
The lipoprotein particles from the AF group promoted more foam cell formation via accelerated phagocytosis by macrophages compared to the control group.
The liposomes ' cytotoxicity and their induction of proinflammatory mediators , intracellular calcium , and neutrophil extracellular traps ( NETs ) were investigated.
The liquids were then fractionated into high-molecular weight ( HMW ) fractions and low-molecular weight ( LMW ) fractions.
The liquid wax is an important substrate for a variety of industrial applications and is used in skin treatment preparations.
The literature citations show that adequately trained individuals should ideally conduct several forms of MT to obtain optimal benefit.
The literature concerning music and dementia was considered and analyzed.
The literature concerning subjects who have reading difficulties has repeatedly noted their abnormal eye movements.
The literature consistently confirmed benefits of lifestyle interventions to physical function assessed at the clinical level.
The literature documents mixed results , due possibly to variability between studies in task design.
The literature for dance in PD is growing , but many knowledge gaps remain , relative to what is known in older adults.
The literature has demonstrated that the continuity of diabetes care can lower medical service utilization and expenses.
The literature has documented a positive relationship between walkable built environments and outdoor mobility in older adults.
The literature has shown a minor complication rate.
The literature has suggested that the use of insulin sensitizers and statins is correlated with a lower rate of cognitive decline in older persons.
The literature has varying reports on the overall incidence of allergic contact dermatitis with advancing age.
The literature is limited by small sample sizes that reduced statistical power to detect true differences.
The literature is quite controversial on this matter.
The literature offering evolutionary explanations of the male longevity deficit does not address temporal variation in the deficit.
The literature on age-friendly communities is predominantly focused on a model of urban aging , thereby failing to reflect the diversity of rural communities.
The literature on health screenings and services demonstrated the important role of health checks in identifying previously undetected conditions.
The literature on patient-physician interactions has largely ignored the perspectives of older adults with multiple morbidities.
The literature on this topic is limited , and no study examined this matter for peripheral venous catheters.
The literature on visuomotor adaptations during reaching suggests , however , that older adults have little problems in adapting their motor behavior.
The literature provides evidence that people living with dementia or MCI can learn how to use this technology and that they enjoy doing so.
The literature provides several studies concerning their applicability in different geographic contexts.
The literature provides solid evidence that UV can induce considerable damage to structures of the eye.
The literature review discovered seven studies on aging , as well as five that lend themselves to a framework oriented toward research on aging.
The literature review has identified that gerontological nursing does not feature highly as a career goal.
The literature search provided @number@ studies that were eligible for inclusion , involving @number@ animals and @number@ human subjects in total.
The literature search was performed using key words and phrases relevant to fertility treatments in older women.
The literature should be expanded in upcoming years to capture associations between country of birth and mortality more clearly.
The literature supports the use of vertebroplasty in conjunction with pedicle screw-based instrumentation for treating more severe spinal deformities.
The literature , though sparse with regard to the neuropsychological underpinnings of this kind of prospective memory task , is consistent with the present hypothesis.
The live attenuated zoster vaccine generates immune responses similar to HZ.
The live delivered pregnancy rates for recipients < or = @number@ was @percent@ vs. @percent@ for women > or = age @number@
The live delivered pregnancy rate was @percent@ for women > or = age @number@
The lived experience of gardening was explored through hermeneutic phenomenological analysis.
The liver can fully regenerate itself by a compensatory regrowth in response to partial hepatectomy or injury.
The liver experiences various changes with aging that could affect clinical characteristics and outcomes in patients with liver diseases.
The liver is a vital organ involving in various major metabolic functions in human body.
The liver is known to be a target tissue for estrogen signaling , but the physiological role of this signaling is not well characterized.
The living arrangement in which they eat alone is important in identifying those with the greatest risk.
The living environment plays a key role in the \ "Aging in Place \ " strategy.
The LJH makes control of each multijoint movement transparent.
The LLF was negatively correlated with SOD ( r = -0.461 ; P = 0.010 ) .
The LMF from soy sauce suppressed the AGE-induced RAGE trafficking to lipid rafts.
The LMNA gene gives rise to lamin A and lamin C through alternative splicing.
The LMN loss was most severe in ALS-FTLD , followed by FTLD-ALS and FTLD without ALS.
The load at fracture and shear punch values of each specimen were recorded after 24-hour storage in distilled water.
The load-bearing fraction attributed to collagen ( ani ) oscillated from @number@ to @percent@ between diastolic and systolic pressures during the cardiac cycle.
The load effect was the opposite of expectation : the N1 to task-irrelevant auditory events was smaller under high load.
The loading and maintenance doses were doubled in the high-dose cohort ( n = @number@ ) .
The loading efficiency of P. aviculare extract in both liposomes was calculated to be about @percent@.
The loading required to open packaging should be understood to ensure that packaging design is developed to be inclusive.
The localisation and expression of GDF11 in the lungs were investigated by immunohistochemistry and quantitative reverse transcription PCR , respectively.
The localization and the proportion of cells positive for OGG1 were determined by immunofluorescence.
The localization of CD44 in lipid rafts , which is required for myofibroblast differentiation , was inhibited by the reduction of sialylation.
The localizations cheek , forearm and neck showed the highest correlation with age , while cleavage showed only low correlation.
The location and relation of the caudate tail to the temporal horn and adjacent brain parenchyma were categorized.
The location of epileptic foci is variable , as is etiology.
The location of neuropathological changes in AD patients indicates the potential diagnostic utility of olfactory tests.
The location of the ACA lesion on the body was compared with that of erythema migrans ( EM ) .
The location of the center of mass of the STN was not affected by contrast.
The location of the COM , however , did not differ between the two task conditions.
The locations of arterial pressure wave reflection , along with arterial stiffening , have a major influence on the timing of the reflected wave.
The locus coeruleus ( LC ) noradrenergic system regulates arousal and modulates attention through its extensive projections across the brain.
The log10 CD14 ( + ) HIV DNA was associated with HAND in unadjusted and adjusted models ( p = @number@ ) .
The logistic regression analysis showed that low SPPBm was associated with grip strength ( OR : @number@ @percent@ CI : @number@.84-0.92 ) independent of SMI.
The logit model revealed that facial pore widening were associated with gender , age , oily skin , sun protection and anti-aging cosmetic.
The longer a patient with osteoporosis complies and persists with treatment , the lower the risk of fracture.
The longest follow-up period was @number@ years.
The longest PLTs were measured on the chest or waist instead of other locations , such as the thigh and shank.
The longevity of brain neurons depends on their capacity to respond to and repair extensive ongoing DNA damage.
The longevity of the results beyond the mean follow-up period of @number@ months needs to be determined.
The longevity of these populations has not changed despite long-term ITN use.
The longevity regulator SIRT1 is an enzyme catalyzing the deacetylation of protein substrates , in turn modulating their biological functions.
The longitudinal analysis of treatment effects revealed a heterogeneous pattern of decelerated loss of gray matter volume associated with intensive glycemic treatment.
The longitudinal analysis used 40-month follow-up data to evaluate differences in progression of volume loss between intensive and standard glycemic treatment arms.
The longitudinal cognitive trajectories indicate that heterozygotes would have an advantage in very late life.
The longitudinal dataset revealed a significant shift from evening type to another type from @number@ to @number@ ( p = @number@ ) .
The longitudinal model is then used as a reference for the cross-sectional analysis.
The longitudinal sample bias towards healthy survivors is likely to underestimate these results.
The long-lasting hypothesis stating that mtDNA mutations emanate from oxidative damage via a self-perpetuating mechanism has been extensively challenged in recent years.
The long NPs also tended to be shifted to the end of the sentence , whereas short NPs tended to be positioned after the verb.
The long-range goal of our research is to reduce the incidence of CVD-related illness and death among aging law enforcement officers.
The long-term aging study suggests that the cements may have a long-lasting antibacterial function.
The long-term benefits of viral eradication by DAAs in the elderly await further explorations.
The long-term effectiveness of chlorhexidine as a matrix metalloproteinase ( MMP ) inhibitor may be compromised when water is incompletely removed during dentin bonding.
The long-term effect of BRS on memory changes may suggest a role of the ANS in cognitive decline.
The long-term effect of earthquake was assessed using the Mental Health Continuum-Short Form questionnaire.
The long-term effects of footwear interventions on balance , gait , and the prevention of falls in older people require further investigation.
The long-term effects of long-acting testosterone undecanoate ( TU ) in a large number of LOH men have not yet been reported.
The long-term function of cilia is hypothesized to regulate cell cycle.
The long-term interactions between HIV infection , treatment , and CMD remain to be elucidated in the African population.
The long-term memory ( LTM ) score of the Auditory Verbal Learning Test ( AVLT ) was the primary outcome measure.
The long-term safety and efficacy of allogeneic MSCs for cardiac repair remain to be established.
The long-term stability and γ-sterilisability of bioactive layers is the precondition for the application of implants.
The long tube was passed into the proximal part of obstruction or the proximal end of ileum driven by intestinal peristalsis.
The long version of the guidance will be available on the EFGCP's website : www.efgcp.be / .
The Lon Protease is a key enzyme in the degradation of oxidized proteins within the mitochondrial matrix.
The Lo-Old , but not the Hi-Old , showed source memory performance decrements compared to the Young.
The loss of active Pin1 leads to the accumulation of abnormal tau and the overproduction of β-amyloid , the cardinal features of Alzheimer's disease.
The loss of complexity in physiological systems may be a dynamical biomarker of aging and disease.
The loss-of-function of G2385R correlates with several cellular phenotypes that have been proposed to be kinase-dependent.
The loss of lean muscle mass occurring with advancing age is termed sarcopenia.
The loss of muscle mass and strength with aging , referred to as sarcopenia , is a prevalent condition among the elderly.
The loss of muscle mass and weakness that accompanies ageing is a major contributor to physical frailty and loss of independence in older people.
The loss of muscle mass with aging has been , at least partly , attributed to a blunted muscle protein synthetic response to food intake.
The loss of raptor ( regulatory associated protein of mTOR , complex @number@ ) an essential mTORC1 component , has the opposite effects.
The loss of Rb1 function is a key contributor to the pathogenesis of both neoplasms.
The loss of sons may partly explain a subtype of late-life risk of suicide or mood disorders especially in the oldest-old.
The loss of synaptic mitochondria is an early pathological change that might cause later degenerative events.
The loss of taste not only affects quality of life , but can also cause weight loss and health problems in the elderly.
The loss of the outer segments occurred gradually over @number@ month , and during this time the genetic signature of cones decreased.
The Lothian Birth Cohort @number@ ( LBC1921 ) completed the MHT at ages @number@ and @number@
The Lothian Birth Cohort @number@ ( LBC1936 ) completed the MHT a second time at age @number@
The Lothian Birth Cohort @number@ ( n = @number@ ) completed cognitive tests aged @number@ having taken an intelligence test aged @number@
The low association of the PBS-ST scale with other measures suggests that the scale taps unique constructs.
The low-barrier group reported significantly higher physical activity engagement and improved mental health quality of life than the high-barrier group.
The low bioavailability of many of these molecules poses a problem for both the study of their activities and their utilization.
The low-density lipoprotein receptor-related protein @number@ ( LRP1 ) is a multifunctional endocytic receptor abundantly expressed in neurons.
The low education level included illiterate and elementary school.
The lower binding site was found more constructive favorable for binding.
The lower extremities of both groups behaved like a simple spring-mass system at all three hopping frequencies.
The lower face is treated with botulinum toxin to achieve a harmonious facial profile.
The lower levels of intracellular EC observed under serum-deprivation were associated with increased formation and secretion of ApoB.
The lower likelihood of overweight was observed among men , smokers , and those aged @number@ years and more.
The lower limit of normality ( LLN ) for FEV1 / FVC was applied to establish the occurrence of airway obstruction in the elderly population.
The lower limit of quantification ( LLOQ ) was @number@.3pmole menadione / mL urine.
The lower PF and absolute and relative RFD values for the old men may contribute to the increased functional limitations often observed in older adults.
The lower portion was at the L3 in small children and at L2 as children approached puberty.
The lower rate of jaw osteonecrosis in patients without cancer was also confirmed in a number of sensitivity analyses.
The lower risk of clinical fracture that was seen with romosozumab was evident at @number@ year.
The lower risks indicate a healthy-migrant-effect , whicht was primarily effective shortly after the immigration event.
The lower values of scan-rescan variability for all DKI parameters were found for the inferior level.
The lowest CAC was observed in those who started HRT within @number@ years after menopause.
The lowest CBF in nocturnal dippers was observed in subjects with maximal STDE daytime.
The lowest increase was observed in group @number@ ( P < @number@ ) .
The lowest levels of friction were observed with the as-received Superelastic Titanium Memory Wire on metallic brackets.
The lowest levels of pleasure and interest were observed for music.
The lowest physical HRQL was associated with amputation.
The lowest psychological distress was found in older Japanese.
The lowest risk group ( ISAR-HP = @number@ ) scored consistently higher on functioning and HRQoL than all other groups.
The lowest score was sweating , which all patients scored @number@
The lowest SEP group was less likely to increase consumption compared to high SEP ( RR @number@ @percent@ CI @number@ to @number@ ) .
The lowest tertile had the lowest triglyceride and highest high-density lipoprotein levels ( P < 0.05 ) .
The lowest value was obtained by BAFC ( @number@ ) .
The low frequency power spectrum increases with age only in the posterior cingulate cortex and posterior default mode network.
The low incidence rate of prostate cancer does not reflect the actual statistics of this disease in Asia.
The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the development of diseases which usually occur in the elderly.
The low levels of Caspase-6 in fetal and adult brain indicate that increased expression as observed in Alzheimer Disease is a pathological condition.
The low percentage of depressed patients with COPD seeking psychiatric treatment suggests that there is an unmet need in the psychiatric care of COPD patients.
The low pH solves the foaming problem.
The low relative ASM group was older and had higher insulin and homeostatic model assessment of insulin resistance values at baseline.
The low-to-high frequency power ( LF / HF ) ratio of RRI was calculated to represent sympatho-vagal balance.
The LPC data indicate that retrieval mode may play an important role in the successful recollection of conceptual stimulus information.
T helper ( TH ) @number@ cells have been implicated in the development of autoimmune and chronic inflammatory diseases in humans.
The L / P ratio decreased from @number@ to @number@ with age ; however , this decrease was only significant in men.
The LRP-TW may offer a clinical intervention program for supporting cognitive and mental performance in individuals with dementia.
The LSA questionnaire summarizes where people travel ( @number@ levels from room to places outside of town ) , how often and any assistance needed.
The LSCS group showed significantly more CD34-positive capillaries than the control group ( P = @number@ ) .
The LS group had a shorter unipedal stance time and a longer normal and fast @number@ MWT than the non-LS group.
The LS , RS , CS , and AT of the middle-aged group also decreased gradually.
The LTL was measured by real-time quantitative polymerase chain reaction.
The LTR estimation is important because it could be more easily comprehended by clinicians and patients.
The LTSS industry should also adapt to meet the need for formal services , which will likely continue to grow.
The L-type Ca ( 2 + ) channel inhibitor isradipine did not inhibit oscillation-linked exocytosis.
The lumbar lordosis for standing and the range of motion for maximal upper body flexion ( RoF ) and extension ( RoE ) were determined.
The lumbar spine range of motion was significantly different between individuals with and without SNs ( @number@.4° vs. @number@.9° , ρ < @number@ ) .
The luminal diameter of a common terminal arteriole ( TA ) controls blood flow through up to @number@ capillaries belonging to a single MVU.
The luminance range of the monitor was extended using neutral density filters.
The lung age and the chronological age of the individuals in each group were compared in isolation and between the two groups.
The lung ages , like any other organ , with progressive functional impairment and reduced capacity to respond to environmental stresses and injury.
The lung ages , resulting in decreased function and reduced capacity to respond to environmental stresses and injury.
The lung just like all other organs is affected by age.
The lung matures by the age of @number@ and age-related changes start around middle age , at 40-50 years.
The lung may directly develop COPD in old age.
The LV CSF diffusivity may offer a useful quality assurance measure and become a potential noninvasive marker of deep brain temperature.
The LV group performed one set of each exercise , while the HV group performed three sets , @number@ days / week.
The LV peak early diastolic longitudinal strain rate ( GSRE ) was measured using a two-dimensional speckle tracking imaging technique.
The lymph node count did not have a significant impact on outcome overall , whereas the LNR proved significant for stage III.
The lymphocyte subsets did not vary between groups.
The lysosomal membrane is the locus for sensing cellular nutrient levels , which are transduced to mTORC1 via the Rag GTPases and the Ragulator complex.
The lysosomal transmembrane protein , SLC38A9 , is required for mTORC1 activation by cholesterol through conserved cholesterol-responsive motifs.
The lysosome distribution was essential for mTORC1 function , as disruption of the Ragulator complex abolished mTORC1 activation by amino acids.
The m-AAA protease preserves proteostasis of the inner mitochondrial membrane.
The MacArthur Competence Assessment Tool for Clinical Research ( MacCAT-CR ) was the most frequently cited.
The macrostructure , microstructure , and neural connectivity of the thalamus changes across the adult lifespan.
The Magic Carpet ( MC ) is a new electronic device translating the traditional Corsi Block-tapping Test ( CBT ) to navigational space.
The magnification correction made the most correlations positive.
The magnitude and distribution of diffuse WMI are related to both the timing of appearance and regional distribution of susceptible preOLs.
The magnitude of age differences in volume varied among the regions.
The magnitude of decrease in vasoreactivity in hypertension without stroke was comparable to the magnitude of decrease in vasoreactivity in stroke without hypertension.
The magnitude of differences in carotid artery intima-media thickness may represent greater vascular aging.
The magnitude of discrepancy increases with lower SCr , lower BMI , and higher age.
The magnitude of expression of the molecules increased significantly on activated blasts after mitogen stimulation compared to their baseline levels in resting cells.
The magnitude of improvements was greater in older age groups gradually closing the gap in athletic performance between younger and older participants.
The magnitude of ITB depends on the duration of excluded immortal time and the prognosis of each cancer.
The magnitude of phoria adaptation decreased as a function of age ( r = -0.33 ; p = 0.04 ) .
The magnitude of the difference between the mean scores obtained from children / adolescents and that of their proxy respondents was evaluated through effect size.
The magnitude of the increase in F2 slopes was significantly less in the PD than HC group.
The magnitude of the problem and current treatment guidelines for lung cancer are reviewed with a focus on barriers specific to the elderly.
The magnitude of these changes demonstrated significant differences among groups ( P < @number@ ) .
The magnitude of this issue is becoming more evident with an aging population and an increasing number of older individuals.
The magnitude of unmasking could not be explained by any of the factors assessed in this study.
The magnitudes of these associations were large , for example , the equivalent of almost @number@ years of chronological age for those CMV seropositive.
The magnitudes of waves b-e are normalized by that of wave a for within- and between-patient comparison.
The MA group was predominantly aerobically trained with some resistance exercise incorporated in their routine.
The mail-administered assessment included the CAB-SR and other care recipient and caregiver measures.
The main aim in the treatment of orthogeriatric patients who suffered from a proximal femoral fracture is the preservation of function and independency.
The main aim of this chapter is to review preclinical studies that have evaluated interventions which may aid in preventing or delaying age-related behavioural decline.
The main aim of this study was to establish whether DCAF4 ( DDB1 and CUL4-associated factor @number@ ) is associated with LTL.
The main aim of this study was to gain more insight into the development of MCs in the Netherlands since @number@
The main aim of this study was to investigate the risk factors and consequence of LTCFs-acquired infections in Taiwan through a 16-month follow-up.
The main analyses involved a multiple single-case method , by which we tested for differences among each patient's performance rates on the three task types.
The main analyses were performed using quantile regression.
The main analysis revealed a positive overall random effect of exercise intervention on cognitive function in patients with chronic diseases.
The main areas of needs explored in these instruments were : information , psychosocial , social , psychoeducational and other needs.
The main barriers to cataract surgery were the high cost ( @percent@ ) and people being unaware that treatment was possible ( @percent@ ) .
The main barrier to vaccination was lack of knowledge regarding the need for and risks and advantages of influenza vaccination.
The main benign diseases , symptoms or signs involving the GI tract are discussed , debating the potential role of a multidisciplinary approach when appropriate.
The main cause is vitamin B12 malabsorption resulting from a type B atrophic gastritis.
The main cause of failure was secondary caries.
The main cause of falling was stumbling due to irregularities on the ground.
The main cause of fertility drop is rapid decrease of ovarian follicle count.
The main causes of a reduced range of motion are degenerative joint diseases and increased stiffness of collagen tissue.
The main causes of blindness were cataract ( @percent@ ) , glaucoma ( @percent@ ) and age-related macular degeneration ( @percent@ ) .
The main causes of death in French Olympians are neoplasms , cardiovascular diseases , and external causes.
The main causes of trauma were physical aggression , traffic accidents , falls and domestic accidents.
The main challenges presented by our framework are finding the most suitable time sequence similarity and aggregation of the retrieved UMLS concepts.
The main clinical manifestations were dyspnea , productive cough , fever and chest pain with hypoxemia via blood gas analysis.
The main color variation was observed within the dried specimens after @number@ hours of immersion.
The main component of CSE , linolenic acid , was determined by gas chromatography-mass spectroscopy.
The main conclusions are that ( @number@ ) the brain shrinks in volume and the ventricular system expands in healthy aging.
The main constituents of amyloid fibrils are atrial natriuretic peptide ( ANP ) and the N-terminal part of its precursor form ( NT-proANP ) .
The main contribution of this work is to devise a proper coupling model at the interface between these two components.
The main corneal higher order aberration is the Z ( @number@ ) spherical aberration which has a positive value and increases with age.
The main correlates of financial preparedness were financial knowledge and involvement in financial activities.
The main criterion of evaluation is acute toxicity.
The main dependent variables were influenza vaccination uptake in the year @number@ and the reason for receiving or refusing vaccination.
The main dietary patterns were identified by factor analysis.
The main difference between countries concerned the residents ' cognitive status that influenced their degree of involvement.
The main differences were due to cultural gender issues.
The main differential diagnosis is transient global amnesia ( TGA ) .
The main drawbacks to retinoid use are local irritation and erythema that can limit utility in some patients.
The main effect of the age category was observed in muscle strength and physical performance parameters.
The main end-user group is patients above the age of @number@ years.
The main enzymes which lead this process are DNA-dependent DNA polymerases.
The main exposure of interest was the last HbA1c level collected in the year preceding the observation period.
The main factor responsible for this is TNF-α , which promotes first MDSC migration , then osteogenic differentiation at low concentrations.
The main factors contributing to earlier onset of menopause and menopausal symptoms were lower educational level , poor economic status , and smoking.
The main findings indicated that older adults ' response times ( RTs ) did not differ across the valence picture.
The main finding was a tendency for lower total number of hospital days for patients assigned to telemonitoring.
The main focus is on muscle strength and power , which are closely associated with mobility and functional capacity among older populations.
The main focus lies on the impact of cognitive and physical activity on neuroprotection.
The main focus of this study is to illustrate the applicability of latent class analysis in the assessment of cognitive performance profiles during ageing.
The main function of SCs is regeneration and skeletal muscle-build up.
The main function of the skin is to protect the body against exogenous substances and excessive water loss.
The main gaps that should be filled to achieve this objective are examined.
The main goal of a therapeutic procedure should be improvement of health-related quality of life ( QoL ) .
The main goal of this paper is to validate the CWI in a sample of older adults.
The main goal of this study was to determine whether seizure semiology differs between older and younger adults with epilepsy in the outpatient setting.
The main goal of this study was to investigate whether brain insulin infusions improve spatial memory in aged and young rats.
The main goals of lung transplantation are to prolong survival and improve the quality of life.
The main hormetic agents identified so far are irradiation , heat , heavy metals , antibiotics , ethanol , pro-oxidants , exercise and food restriction.
The main hypothesis of this study proposes that the perception of motion will subsequently influence cognitive processing in a specific , emotional manner.
The main inclusion criteria were a minimum of two drug prescriptions and duration of use of @number@ or more days.
The main inclusion criterion for study was a baseline serum 25OHD < 20ng / ml ( 50nmol / L ) .
The main increase was in the percentage of patients over @number@ years : @time@ % in @number@ versus @percent@ in @number@
The main independent variable was a lapse in Medicaid enrollment.
The main indication for VKA therapy was atrial fibrillation ( AF ; @number@ % ) .
The main indications were patients with vertically narrow palpebral aperture or an up-slanting appearance.
The main kind of death by external causes among men is aggressions , followed by transport accidents , the opposite of women.
The main management trend for allergic rhinitis in elderly patients is the same as the trend in young patients.
The main mediator of this effect seemed to be improvements in HbA1c.
The main objective is to uncover the activities that impede or stimulate actual volunteering and / or the likeliness to volunteer at an older age.
The main objective must be to fight against any form of age discrimination ( ageism ) .
The main objective of this study is to evaluate the gender-specific relationship between MS and CAVI in the general Chinese population.
The main objective of this study was to determine the types of adenoviruses causing keratoconjunctivitis in Saudi Arabia.
The main objective of this study was to perform an unbiased , whole transcriptome search for genes that associate with intrinsic skin youthfulness.
The main objective of this study was to test the linearity of the oxygen delivery-utilization balance during random moderate exercise.
The main objective of this study was to test the predictive value of some different variables on the poor Self-Rated Health among elders.
The main objective was to determine if there is in vivo regulation of telomere length in situ by atherosclerotic lesions.
The main objective was to estimate the adjusted annual costs and use of hospital healthcare resources in frail older adults compared to non frail ones.
The main outcome is the caregiver's burden assessed by the Zarit Burden Index at @number@ @number@ and 18months.
The main outcome measurement was frailty , assessed using the Cardiovascular Health Study method.
The main outcome measures recorded were readmissions and hospital nights @number@ months after discharge.
The main outcome measures were incident ADRs during hospital stay.
The main outcome measures were insulin sensitivity , oxidative capacity and oxidative stress.
The main outcome measures were mean ACTH concentrations , pulsatile ACTH secretion , and ACTH approximate entropy ( ApEn ) .
The main outcome measures were physical activity , smoking , alcohol consumption and diet.
The main outcome measures were the diagnosis-by-age interaction on whole-brain-averaged WM FA values and FA values from @number@ major WM tracts.
The main outcome measure was 5-year mortality.
The main outcome measure was a CAC score > 100.
The main outcome measure was calcification of the aorta and iliac arteries in relation to PPI use.
The main outcome measure was the incremental cost per quality-adjusted life year ( QALY ) gained.
The main outcome measure was total number of utilization events.
The main outcome of this analysis is uncorrected visual acuity after @number@ months , adjusted for baseline acuity.
The main outcomes included depression , quality of life , and , after the follow-up period , also cardiovascular disease and cancer.
The main outcomes of interest are recruitment , adherence , retention and acceptability.
The main outcome suggests that the perception of social support improves explicit memory and quality of life and reduces depression in active older adults.
The main outcomes were baseline DCD , GCD , and SMR , and @number@ months IOP.
The main outcomes were change in lean body mass and change in muscle strength for both the meta-analysis and the pooled analysis.
The main outcomes were hazard ratios ( HR ) of mortality and median age at death.
The main outcome variable was the Global Cognitive Score assessed using the MindStreams ( ® ) mild cognitive impairment assessment , a computerized cognitive assessment.
The main outcome variable was the place of death ( hospital vs. home ) .
The main outcome was childhood mortality in FDR and SDR of men with SA and their matched controls.
The main outcome was recurrent falls ( ≥2 ) in the ensuing @number@ months.
The main outcome was self-reported receipt of mammography in the last year.
The main outcome was the potentially inappropriate drug use according to each set of criteria , separately and combined.
The main outcome was the proportion of subjects achieving recommended clinical targets for ≥ @number@ of uncontrolled CVD risk factors at 12-month.
The main phenolic compounds identified were phenolic acids and flavonoid aglycons.
The main physiological function of adipose-derived stromal / progenitor cells ( ASC ) is to differentiate into adipocytes.
The main prediction of this framework is that action perception should be strongly correlated with parameters of action execution.
The main prediction was that age-related deficits in emotion recognition will only be evident in context-poor tasks.
The main predictors of adiponectin level are age in men ( p = 0.027 ) and BMI in women ( p = 0.003 ) .
The main predictors of leptin level are BMI and the testosterone / estrone ratio in both sexes ( p < 0.05 ) .
The main predisposing factor was dry skin.
The main premise is simple : the biochemical processes that maintain life , secure homeostatic equilibrium , and prevent the collapse of health require energy.
The main prescription treatment options employed were AD-specific medication ( @percent@ ) and medication for mood or behaviour ( @percent@ ) .
The main processes involved in skin aging are intrinsic and extrinsic.
The main purpose of this study is to determine if the shift in genuine scores can be attributed to aging or not.
The main purpose of this study is to evaluate the quality of outpatient services for elderly patients in Taiwan.
The main purpose of this study was to evaluate the survival impact of MetS among older men aged @number@ and over in Taiwan.
The main questions posed in ageing theories are how ageing evolved and whether or not it is programmed.
The main questions were whether personality scales reflected coherent units of trait development and thereby coherent personality traits more generally.
The main question this review aims to answer is whether rheumatic diseases cause accelerated aging or that accelerated aging drives rheumatic diseases.
The main reason behind these effects seems to be related to a like \ "hormetic \ " response induced by zinc.
The main reason for continued exercise participation was to maintain health ( @percent@ ) .
The main reason for non-application was the physician's judgment of the patient's clinical condition.
The main reasons for ART calls were wandering and physical aggression.
The main reasons for not accepting surgery were obtained using a questionnaire.
The main results indicate that the elderly group increased from @percent@ in @number@ @percent@ in @number@ to @percent@ in @number@
The main results of the study of the ageing changes of skin blood perfusion using this method has been also presented.
The main results showed that ( a ) older adults used a smaller strategy repertoire ( Expt.
The main results were essentially unchanged using different assumed misclassification rates or imputation of age of infection.
The main risk factor for a number of diseases , including cancer , is aging.
The main risk factor for development of non-melanoma skin cancer and its precursor lesions is chronic UV exposure.
The main risk factors to develop tinnitus or hyperacusis are hearing loss , social stress and age.
The main risk is falling.
The main safety concern about GLP-1Rx agonists use is the possible association with increased risk of pancreatitis and / or tumors.
The main source of secondhand smoke switched from a spouse in @number@ to offspring in @number@
The main specific protein-ligand interaction is π-π stacking of phenothiazine ring with indole group of Trp82.
The mainstay for treatment , however , remains draining with an indwelling catheter or clean intermittent clean catheterisation.
The mainstay of treatment in persisting androgen deficiency is to restore normal physiological levels of testosterone by using exogenous testosterone.
The main still unanswered question is : What is the therapeutic role of carotenoids in atherosclerotic disease ?
The main strategy to reduce the impact of influenza infections in the elderly population is vaccination.
The main study is currently ongoing and is planned to finish on @date@ .
The main subjects in all contents were sex , gender differences , aging , grandparenting , politics , faith , and alcohol.
The main symptoms of the patient were left side chest pain , with occasional cough.
The main symptoms were chest pain and fever.
The main targets of ROS are DNA , proteins , and membrane phospholipids.
The maintenance of a high level of performance in aging has often been associated with changes in cerebral activations patterns for various cognitive components.
The maintenance of an active private and social life is a method of fighting premature aging associated with infirmity and disease.
The maintenance of any training benefits was assessed after @number@ months.
The maintenance of cellular proteostasis is dependent on molecular chaperones and protein degradation pathways.
The maintenance of chronic immune activation due to leishmaniasis or even due to microbial translocation is associated with immunosenescence and may contribute to frequent relapses.
The maintenance of effects from home-delivered cognitive-behavioral therapy ( CBT ) was examined.
The maintenance of eukaryotic telomeres requires telomerase , which is minimally composed of a telomerase reverse transcriptase ( TERT ) and an associated RNA component.
The maintenance of genetic integrity was evaluated during in vitro culture by karyotype and microsatellite instability analysis.
The maintenance of genome stability is critical for the suppression of cancer and premature ageing.
The maintenance of genomic integrity by the DDR has also been found to be involved in the process of organismal ageing.
The maintenance of healthy weight in men from adolescence onward may be a useful strategy to avoid the atherosclerotic complications of adiposity tracking.
The maintenance of muscle function into late life protects against various negative health outcomes.
The maintenance of protein solubility is a fundamental aspect of cellular homeostasis because protein aggregation is associated with a wide variety of human diseases.
The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues.
The maintenance of the human genome requires hundreds of proteins involved in DNA repair , DNA replication , chromosome segregation and cell cycle checkpoint responses.
The maintenance of this balance and its modulation can influence pathophysiological mechanisms predisposing to neurodegenerative diseases like AD.
The main variable was disability including basic activities of daily living ( ADLs ) , instrumental ADLs ( IADLs ) , and mobility disability.
The main vascular risk factor for SVD is brain hypoperfusion from cerebral blood vessel narrowing due to chronic hypertension.
The major advantages of urine-based assays are their noninvasive nature and the ability to monitor PC with heterogeneous foci.
The major adverse effect of factor replacement therapy in patients with hemophilia is the development of neutralizing antibodies termed inhibitors.
The major allele of SNP rs3173615 is a risk factor in sporadic FTD , whereas the minor allele seems protective in GRN- and C9orf72-mediated FTD.
The major and minor centroidal axes ( CA ) serve as automated reference points in cross-sections of cadaveric mid-diaphyseal femora and tibiae.
The major barriers to practising geriatric dentistry are the lack of trained faculty members , a crowded curriculum and monetary concerns.
The major barriers to vaccine implementation among healthcare professionals are an incomplete awareness of pneumococcal disease and the vaccination options in adults.
The major barriers were a fear of adverse reactions and the belief in resilience of an older adult.
The major cardiac defects observed are produced by a significant increase in apoptosis , which is dp53-dependent.
The major cause of the development of the SUI is dysfunction of the urethral supporting tissues as a result of aging and childbirth.
The major cause of this increase is the well-known aging of the society in Europe and in the US as well.
The major causes of death were considered in order to deepen the analysis of the observed geographical differences.
The major cellular proteolytic machineries , namely the proteasome and the lysosome , have been shown to dysfunction during aging and age-related diseases.
The major central effects of 11β-HSD2 occur in development , as expression of 11β-HSD2 is high in fetal brain and placenta.
The major complication of shingles is postherpetic neuralgia.
The major component of SP is amyloid β-peptide ( Aβ ) , which has been shown to induce oxidative stress.
The major components of the endoplasmic reticulum stress-mediated apoptosis pathway , including pro-apoptotic factors downstream of the ATF3-CHOP cascade , were dramatically up-regulated.
The major components of the lamina are A- and B-type lamins.
The major difference between the young-adult and postmenopausal pelvic floor was the expansion of fat in between the components of the pelvic floor.
The major difference in the pattern of lipid peaks between ABCA7 and ABCA1 was the high lysoPC / PC ratio of ABCA7.
The major difficulty for the development of therapeutic strategies is to restore a balanced autophagic flux , due to the dynamic nature of autophagy.
The major drivers of cost effectiveness were cost of increasing coverage , effectiveness of the interventions and country-specific factors.
The major effect of phosphorylation and ADP-ribosylation is the disassembly of desmin filaments , while ubiquitylation of desmin leads to its degradation.
The major epigenetic mechanisms are DNA methylation , histone modification and non-coding RNA.
The major facilitators of taking the vaccine were recommendations by , and trust in , health professionals , and a belief in vaccine efficacy.
The major factor involved in these experiments is the use of animal models to assess hippocampal-based spatial memory.
The major findings were that prophylactic physostigmine prevented complete inhibition of AChE by soman and resulted in partial spontaneous recovery of the enzyme by de-carbamylation.
The major function of E-type cyclins is to drive cell division.
The major gender differences as observed suggest the need to further explore gender-specific barriers in leisure participation.
The major goal of cancer therapy is to destroy cancer cells without harming normal cells.
The major immune cells of the brain - microglia and astrocytes - significantly change their morphology and functional state during aging.
The major innovation is that we use labeled activity data from some subjects to predict the activity labels of other subjects.
The majority ( > 70% ) of all PAD encounters occurred in the outpatient setting.
The majority does not know the WHO guidelines regarding the amount of PA for adults aged @number@ and over.
The majority feared being a burden to relatives ( @percent@ ) and becoming unable to master an independent life ( @percent@ ) .
The majority focused on breast and prostate cancer treatment decisions and most studies used a qualitative design.
The majority had a spouse ( @percent@ ) and lived in a rural area ( @percent@ ) .
The majority had long-term HIV ( LTHIV ) , with an average duration of @number@ years since diagnosis.
The majority have abnormalities in triglycerides ( @percent@ ) .
The majority have secondary schooling.
The majority maintained their scores over time , and two smaller groups showed increases and decreases in life satisfaction over time.
The majority ( n = @number@ @percent@ ) of patients were managed in a non-health-care facility location , primarily their own residence.
The majority ( @number@ studies , @number@ participants ) evaluated the effect of dietary supplements on skin appearance among women.
The majority of AA patients have somatic mutations and / or structural chromosomal abnormalities detected as early as at diagnosis.
The majority of ADRs in older people are Type A , potentially avoidable and associated with commonly prescribed medications.
The majority of adverse events were non-serious and the vaccine has not been conclusively implicated with serious events.
The majority of age-related hypermethylated sites were located at CpG islands of silent genes and enriched for repressive histone marks.
The majority of airbag-related UEI appeared to shift slightly from abrasions to contusions with aging.
The majority of articles ( @number@ of @number@ ) utilized reactive postural control paradigms.
The majority of available work has focused on miRNA , and we review the many studies implicating specific miRNAs in the development of the disease.
The majority of cancer incidences and deaths occur in the elderly.
The majority of cases showed small to medium-sized follicular structures with secreted materials.
The majority of cases were heard and decided in lower level courts , addressing a broad range of primarily non-criminal legal issues.
The majority of cilia are formed and maintained by the highly conserved process of intraflagellar transport ( IFT ) .
The majority of clients was female and living alone ( widowed ) .
The majority of communities implemented one or more age-friendly projects.
The majority of data was based on qualitative research investigating factors in the pre-implementation stage.
The majority of deaths in the UK occur in acute hospitals , and older people are particularly likely to die in this setting.
The majority of deaths , @percent@ ( @number@ ) , were among those ≥65 years.
The majority of DPGs were differentially regulated by age and / or CAR activation.
The majority of elder care is provided by relatives , albeit with varying patterns of involvement and responsibility across family structures.
The majority of elderly patients with HF are frail with multiple comorbidities.
The majority of elderly subjects were white men.
The majority of employees worked as part of a three shift ( @percent@ ) .
The majority of existing clinical skin ageing scales were developed for evaluating facial characteristics.
The majority of falls in older adults are due to trips and slips.
The majority of frequent attender visits were appropriate ( @percent@ ) , and of these , @percent@ resulted in admission.
The majority of glaucoma office visits did not discuss medication cost , and providers often did not ask about cost problems.
The majority of golfers can return to preoperative levels in terms of performance ( handicap ) and frequency of play.
The majority of graduates seeks and obtains ABPN certification , and the majority of those who were fellowship trained have maintained certification.
The majority of HBV / D isolates were closely related to D3 sequences.
The majority of health professionals studied ( @percent@ ) had good nutritional knowledge.
The majority of hereditary and acquired myopathies are clinically characterized by progressive muscle weakness.
The majority of HHCW were also exposed to secondhand smoke and occasionally experienced violence.
The majority of individuals considered the question of substitution of factor concentrates in case of bleeding as most important.
The majority of individuals with dementia will first present for care and assessment in primary care settings.
The majority of interventions were delivered to informal carers ( @number@ studies ) , with three of these studies also involving older adult care recipients.
The majority of intracardiac thrombi form in the left atrial appendage ( LAA ) .
The majority of medication trials in men , however , used bone density as the primary outcome rather than fractures.
The majority of neural stem cells ( NSCs ) in the adult brain are quiescent , and this fraction increases with aging.
The majority of neuroimaging studies reported an association between older age and LOBD and the presence of WMHs in LOBD.
The majority of nurses and students correctly identified non-abusive strategies.
The majority of older adults , however , are sedentary and have difficulty initiating and maintaining exercise programs.
The majority of overweight youth remained overweight as adults ; however , the majority of overweight adults were not overweight youth.
The majority of participants agreed that depression is a kind of disease ( Korea @percent@ , Russia @percent@ , USA @percent@ ) .
The majority of participants indicated they would access online cognitive screening.
The majority of participants rated their work ability as ' good ' to ' excellent'.
The majority of participants were female and approximately @percent@ were under the age of @number@ years.
The majority of patients had paraplegia ( n = @number@ @percent@ ) and a metastatic tumor ( n = @number@ @percent@ ) causing their SCI.
The majority of patients on combination therapy were on two or more OADs and higher injectable use was observed in the severely uncontrolled cohort.
The majority of patients , @percent@ in @number@ and @percent@ in @number@ preferred to eat their meal at their bedside.
The majority of patients ( @percent@ ) were initially treated with external beam whole-pelvic radiation with concurrent cisplatin.
The majority of patients ( @percent@ ) were satisfied with their results.
The majority of patients suffer from dry eye symptoms.
The majority of patients were also treated with pulsed dye laser ( PDL ) and / or intense pulsed light ( IPL ) for photoactivation.
The majority of patients with Duchenne muscular dystrophy ( DMD ) have electrocardiographic abnormalities , but the clinical significance of conduction disturbances remains unclear.
The majority of patients with lung cancer present with locally advanced or metastatic disease.
The majority of patients with Major Depressive Disorder ( MDD ) suffer from significant executive dysfunctions.
The majority of people with dementia develop behavioural disturbances , also known as behavioural and psychological symptoms of dementia ( BPSD ) .
The majority of plaques in acute monophasic and relapsing-remitting MS ( RRMS ) were active.
The majority of projects were investigator-initiated grants ( @percent@ ) .
The majority of protein molecules must fold into defined three-dimensional structures to acquire functional activity.
The majority of records included reference to recommended blood tests , informant history and caregiver concerns.
The majority of records ( @percent@ ) were retrospective case studies , qualitative studies , and reviews / commentaries.
The majority of reported adverse events were of grade @number@ or @number@ severity.
The majority of research examining structural-cognitive relationships in aging focuses on the role of age-related changes to grey matter integrity.
The majority of research on sleep-dependent memory consolidation focuses on adults ; hence , the current study examined sleep-related effects on two tasks in children.
The majority of residents with hypoglycemia ( 39 / 42 ) or chronic hyperglycemia ( 45 / 51 ) were insulin-treated.
The majority of respondents ( @percent@ ) do not consider that there is a consensus definition of familial ALS ( FALS ) .
The majority of SNPs , associated with QUS parameters in the Framingham Study , were not replicated in an independent population sample of European men.
The majority of specimens showed evidence of nerve fiber regeneration although confined to the mid- or lower reticular dermis.
The majority of sperm donors and more than one-third of oocyte donors expressed concerns about having donated.
The majority of studies demonstrated no effect of a single comorbid condition on outcomes.
The majority of studies investigated driver avoidance , followed by driver restriction.
The majority of studies ( @percent@ ) were case series without controls.
The majority of studies reported an inverse relationship between BMI and telomere length.
The majority of studies to date have utilised aspatial methods to identify OCC.
The majority of studies used a quasiexperimental , cross-sectional design.
The majority of study participants were very satisfied from the results of the independent treatment using the tested device for wrinkle reduction.
The majority of subjects have a funnel shape-like incisive canal with the broader opening located at its superior.
The majority of subjects receiving oxygen therapy and sustained oxygen therapy were female.
The majority of subjects reported that they perceived improvements in each of the @number@ parameters associated with skin appearance.
The majority of T cells in the skin of both age groups expressed CD69 , a characteristic of skin-resident T cells.
The majority of testosterone-treated anemic participants increased their hemoglobin into normal range.
The majority of the athletes was hypohydrated throughout the day and dehydrated even more during practice despite fluid availability.
The majority of the costs occur in the social care sector , but the costing of informal care is crucial for the cost estimates.
The majority of the current studies also have a relatively a short follow-up period of @number@ months.
The majority of the included studies included a larger percentage of males as compared with females.
The majority of the interviewees ( @percent@ ) has at least a chronic health condition and @percent@ consumed regularly at least one medication.
The majority of the margin of safety and displacement rate variables for the foam floors were significantly lower than the control condition.
The majority of the @number@ respondents consider depression as disease , which should be treated.
The majority of the patients ( @number@ % ) reported a preference for vibration anesthesia with subsequent dermal filler injections.
The majority of the patients reported are pediatric or young adults , and long-term studies able to define the prognosis of the disease are lacking.
The majority of the patients with type @number@ diabetes ( T2DM ) show remission after Roux-en-Y gastric bypass ( RYGB ) .
The majority of the recommendations put forward by the pharmacist or a multidisciplinary team were accepted by physicians.
The majority of the respondents ( @number@ % ) were between @number@ and @number@ years old.
The majority of the results of mexametric measurements-MEX ( melanin level ) and ERYT ( the severity of erythema ) are statistically insignificant.
The majority of the sample consisted of women ( @percent@ ) .
The majority of the sample ( @number@ % ) was in favor of advance care planning completion , most of all younger participants and non-caregivers.
The majority of the sample reported walking independently ( @percent@ ) and not using an assistive device ( @percent@ ) .
The majority of these conditions are diagnosed radiographically , at which point the disease process is often more advanced and challenging to treat.
The majority of these costs ( @percent@ ) resulted from inpatient treatment due to fractures.
The majority of these loci are within CpG islands and there is a positive correlation between age and DNA methylation level.
The majority of these modifications result in compounds that are much more hydrophobic than A2E.
The majority of these mutations are ' background ' mutations that were acquired during normal aging of hematopoietic stem cells.
The majority of these older adults retained optimal positivity ratios over time and appeared to flourish.
The majority of these prescribing indicators pertain to overprescribing and misprescribing , with only a minority focussing on the underprescribing of indicated medicines.
The majority of the studies did not rely on a theoretical framework.
The majority of the symptoms were either unexplained or attributed to medication side effects.
The majority of this work has tended to examine performance on tasks involving young adult faces and prototypical emotions.
The majority of those with dizziness tend to have more than one risk factor , suggesting that dizziness is a multifactorial geriatric condition.
The majority of vaccinations were administered in the perinatal period and within @number@ months of the child's birth.
The majority of women at high fracture risk do not receive active treatment.
The majority of women had diet that \ "needs improvement \ " ( @percent@ ) , and only @percent@ had \ "good \ " diet.
The majority of women in those observational studies had undergone natural menopause and were treated for the relief of menopausal symptoms.
The majority of YLHIV ( 13-24 years old ) are cared for at adult sites , @number@
The majority ( @percent@ ) of DDIs were of the C2 pattern ( severity : moderate ; documentation : probable ) .
The majority ( @percent@ ) of older adults with pain endorsed multiple sites of pain.
The majority ( @percent@ ) of the energy needs of the human body are met by mitochondrial oxidative phosphorylation ( OXPHOS ) .
The majority ( @percent@ ) were classified as overweight and @percent@ had an increased waist circumference , yet only @percent@ of participants were normotensive.
The majority required reoperations.
The majority were male ( @percent@ ) , and the average age at death was @number@ ± @number@ years.
The majority were single site studies incorporating small patient populations.
The major limitation is the frequency of switching from one formulation to another.
The major limitation of our study is the lack of clinical follow-up of participants during life.
The major limitation of this approach is lack of accuracy and precision in estimating EE , especially in low-intensity activities.
The major nutrients present in foods include carbohydrates , proteins , lipids , vitamins , and minerals.
The major objective is to assess , and observe change in , health status over time in a prospective manner.
The major objective was to investigate whether intensive lipid-lowering therapy using the treat-to-target approach yielded greater regression of aortic plaques.
The major pathogenic mechanism of AIDS is the massive apoptotic destruction of the immunocompetent cells , including uninfected cells.
The major predictor for hospital admission was history of a previous fall.
The major predictor of improvement in each agitation measure was a higher baseline score in that measure.
The major problems of chemotherapeutic treatment in cervical cancer are non-specific cytotoxicity and drug resistance.
The major proteins are amyloid-β ( Aβ ) , tau , α-synuclein , and TDP-43.
The major reason for the increased susceptibility to infections in the elderly is the deregulated functions of the immune system.
The major respiratory problem in infancy and early childhood is respiratory exacerbations caused by infections ( particularly viral ones ) , which need hospitalization.
The major risk factor of COPD , which has been proven in many studies , is the exposure to cigarette smoke.
The major risk factors are , however , aging and APOE ε4.
The major risk factors for the increased severity of SVD markers were advancing age and hypertension.
The major risk factors identified are impaired balance and gait , polypharmacy , and history of previous falls.
The major role of vitamin D in humans is to increase the absorption of calcium and phosphatase for the mineralization of the skeleton.
The major source of cellular damage involves the generation of reactive oxygen species produced during mitochondrial respiratory activity of the electron transport chain.
The major thiol / disulfide redox couple in human plasma is cysteine ( Cys ) and its disulfide form , cystine ( CySS ) .
The major transporter for fructose in intestinal epithelial cells is thought to be the facilitative transporter GLUT5.
The maldigestion and malabsorption coupled with altered motility contributes to the development of malnutrition.
The male / female ratio for positive UBTs was @number@ : 1·77.
The male , female ratio was equal for colon ( 1 : 1 ) .
The male gender and childhood conduct disorder are related with higher prevalence rates of ICDs in elderly.
The Male OPAQ™ is a reliable and validated instrument that may be utilized in clinical trials seeking to include male populations.
The male OST was significantly more than the female OST.
The male patient carrying mutation p. I99L presented limb symptom at age of @number@ and died in @number@ months.
The male preponderance in autism prevalence has brought together the disparate topics of sex / gender and autism research.
The males ' aqueductal CSF stroke volumes and average flow rates are significantly higher than those of the females.
The male to female ratio was 4 : 21.
The male to female ratio was @percent@ each.
The malfunction of the death machinery may play a primary role in various pathologic processes , leading to proliferative or degenerative diseases.
The mammalian FOXO family consists of FOXO1 , @number@ @number@ and @number@ are highly similar in their structure , function and regulation.
The mammalian intestinal epithelium is one of the most rapidly self-renewing tissues in the body , and its integrity is preserved through strict regulation.
The mammalian intestinal mucosa exhibits a spectrum of responses after acute injury and repairs itself rapidly to restore the epithelial integrity.
The mammalian Sir2 ortholog Sirt1 regulates metabolic and stress responses through the deacetylation of many transcriptional regulatory factors.
The mammalian sirtuins have emerged as critical regulators of cellular stress resistance , energy metabolism , and tumorigenesis.
The mammalian target of rapamycin ( mTOR ) plays an important role in cardiac development and function.
The mammalian target of rapamycin ( mTOR ) senses nutrients and growth factors to coordinate cell growth , metabolism and autophagy.
The mammalian target of rapamycin ( mTOR ) signaling pathway is a master regulator of cell growth and metabolism.
The mammalian Tsc1-Tsc2 GTPase activating protein ( GAP ) heterodimer is a critical negative regulator of Rheb and mTOR activation.
The management of cancer in older aged people is becoming a common problem due to the aging of the population.
The management of cancer itself may result in the addition of more medications to counteract the adverse effects of antineoplastic treatment.
The management of chronic lymphocytic leukemia ( CLL ) is undergoing profound changes.
The management of chronic lymphocytic leukemia ( CLL ) is undergoing profound changes.
The management of combined presence of cataract and glaucoma is a common clinical challenge.
The management of continence in hospitalized older adults requires more diligence , and further investigation is needed to devise continence promotion methods in hospital settings.
The management of COPD includes smoking cessation , influenza and pneumococcal vaccinations , and the use of short-and long-acting bronchodilators.
The management of ischemic nephropathy may include medical therapy and / or revascularization.
The management of major orthopedic surgery in the elderly prototypically reflects the perioperative risks of geriatric , often very frail patients reflecting an aging population.
The management of patients with festoons is a highly challenging undertaking with potential to drastically alter the appearance of those afflicted.
The management of periprosthetic fractures is an issue of increasing importance for orthopaedic surgeons.
The management of pre-hospital cardiac arrest in children requires psychosocial as well as medical skills.
The management of prostate cancer in the elderly is a major public health concern in most countries.
The management of sarcopenia is primarily focused on physical therapy for muscle strengthening and gait training.
The management of seizure waves in children diagnosed with ASD may result in improves function and reduction of autistic symptoms.
The management of the elderly , surgical , critical care patient is extremely challenging.
The management of this difficult chronic condition could be improved by using pain descriptors to improve analyses of painful sensations.
The management of this group involves internal fixation through a sliding hip screw device or intramedullary fixation device , both of which have good results.
The mandibular angle significantly increased with age for both sexes.
The mandibular vBMD was twice measured with QCT by one operator and resulted highly repeatable ( ICC @number@
The manic episodes are less severe , mixed depression is common , as well as confusion and cognitive impairment.
The manifestation of neutrophilocytosis and lymphocytopenia might be due to age-related features of adaptive reaction in peripheral blood cells during the COPN recurrence.
The manifestation of these alterations relies on the balance between their production and cellular renewal.
The Mann method approached @percent@ in predicting age in older males , but the method did not fare as well on Thai females.
The Mann-Whitney test , analysis of variance ( ANOVA ) , and Bonferroni tests were performed for statistical analysis at @number@ level of significance.
The Mann-Whitney U-test or chi-square test was used for statistical analyses.
The Mann-Whitney U test was used to analyze sex-related differences in the number of medications used among age-stratified subgroups.
The manual method has been previously validated and was used as the reference.
The manuscript introduces these studies ' methods , cautions , results , and problems related to the reports of the results.
The many physiological changes that come with aging modify habits , patterns of behavior , and limit autonomy and functionality of elderly patients.
The MAO-A upregulation resulted in increased 5-hydroxyindoleacetic acid / serotonin ratio , oxidative stress , leading to NF-κB activation , inflammation and apoptosis.
The MAPDAQ-G should be statistically tested for validity and reliability using a larger sample.
The MAPK signaling pathway was hypermethylated with age , consistent with a defective MAPK signaling in aging T cells.
The maps also quantify the variability of the anatomical location of the deep cerebellar nuclei after normalization.
The marginal fit was evaluated by scanning electron microscopy ( SEM ) and dye penetration.
The MARK-AGE project involves @number@ European countries and a total of @number@ research centres.
The marked differences in PA intake among various sociodemographic subgroups need further investigation in relation to health disparities and chronic disease prevalence in the US.
The marked heterogeneity long after maturation raises the prospect that diverse populations harbor distinct roles aside from glucose-stimulated insulin secretion.
The marker of mitochondrial mass COX-IV was also evaluated.
The markers CEA , MMP-2 , and p27 ( kip1 ) were studied by immunohistochemistry in all patients.
The markers were clustered into five factors , and factor scores were related to cortical thickness by general linear model.
The marketing of skin care products for men is evolving and becoming seemingly complex ; further research is warranted.
The masker-probe intervals ( MPIs ) were varied at @number@ @number@ @number@ @number@ and @number@ sec , with an interpair interval of @number@ sec.
The mask interference demonstrated the perceptual nature of the priming effect which supports the sensory-dependent theory of knowledge.
The mass increase after biomodification followed the same order aforementioned.
The massive accumulation of infected erythrocytes in the placenta has been suggested to trigger the deleterious effects of malaria in pregnant women and their offspring.
The mass of liver changes cyclically as well as body weight.
The mass ratio of P / S decreased significantly in the LCFs in childhood.
The mass spectrometric analysis results were consistent with the Western blot validation.
The matching ( and proper concordance ) are useful for the choice of the individual regimens of medical treatment.
The matching criteria were age ( mean = @number@ years ) , sex , country , and type of housing.
The matching procedure allowed us to assess the importance of hearing loss as an explanatory factor of age-related STM decline.
The material consisted of surgical samples of testicular tissue from @number@ patients with orchidectomy for prostate carcinoma.
The material properties were determined by calibrating the finite element model using the L4 cortical shell strains of the anterior centre measurement site.
The material stiffness , extensibility , and degree of anisotropy of the leaflet samples were quantified.
The materials were extracted from the rat's body , approximately @number@ days post-implantation.
The mathematical stretch-dependent model of accommodation presented may have utility in investigating lens behaviour at states other than the relaxed or fully accommodated states.
Thematic analysis and synthesis was applied to the three qualitative studies and the qualitative data of the mixed-method studies.
Thematic analysis of interview transcripts led to a conceptual model of aging better together intentionally.
Thematic analysis was employed for the textual data using MAXQDA @number@
Thematic analysis was employed to analyze interview transcripts , using a realist approach to better understand the contexts , mechanisms and outcomes of technology acquirements.
Thematic analysis was employed to illuminate residents ' perspectives on the nature of social relationships in this setting.
Thematic analysis was performed using an inductive approach.
Thematic analysis was used to identify themes and findings were reported qualitatively using framework-based narrative synthesis.
Thematic analysis was used to synthesise the findings.
Thematic content analysis served to analyse our data with the grounded theory approach.
Thematic synthesis was used to analyse the data.
Thematic synthesis was used to integrate the emergent themes into an overall analytical theme.
The maturation of in vivo neuroimaging has led to incredible quantities of digital information about the human brain.
The maturation of locomotor adaptation follows at least two time courses , which we propose is determined by the developmental state of the cerebellum.
The maturation process involves the transfer of secondary metabolites , mainly phenolics , from the wood to the liquid.
The maximal stability , center of pressure ( COP ) velocity , and percentage ankle strategy were obtained under six different balance conditions.
The maximal stress value in the ACL had also altered while the stress distribution did not varied obviously.
The maximal vertical loss in micrometers was determined with profilometer.
The maximal Youden's index was used to estimate optimal cut-off values for the indices.
The maximum abduction degree of digital web-spaces was 40-60 degrees.
The maximum abduction degree of digital web-spaces was 5-10 degrees.
The maximum allowed difference between the prediction method result and the ETT that fit was defined as @number@ mm.
The maximum diameter of the aneurysms was 44-72 mm ( mean , @number@ mm ) .
The maximum endometrial thickness at pickup resulted important to predict the pregnancy rate and the chances to detect ongoing pregnancy.
The maximum failure load during pull out test was documented by a universal material testing machine.
The maximum follow-up period after the initial MI was @number@ years ( median , @number@ years ) .
The maximum grip force was stronger in rotating shift work nurses ( p = 0.0001 ) .
The maximum isometric torque of knee extension at a knee angle of 90° was measured.
The maximum lean angles for forward leans were @percent@ greater than sideways leans and @percent@ greater than backward leans.
The maximum score possible was @number@
The maximum walking speed of participants was recorded.
The maximum wet weight was @number@ g.
The maximum wrinkle depth ( Rmax ) of an eye corner wrinkle was obtained.
The MCA deceleration post-hyperventilation by @percent@ in young people decreases to @percent@ and to @percent@ respectively in the older categories.
The M-C analysis was available for @number@ stones ( @percent@ ) : multiple morphological types were concomitantly identified in @percent@.
The mCAT mice have demonstrated the largest effects on life span and healthspan extension.
The MCI group had higher protein levels of spinophilin compared with mAD and sAD , and higher spinophilin-ir dendritic spine density compared with sAD.
The MCI group performed worse than the CN group on the off-road screening tests.
The MCIS is effective in detecting aMCI , and in discriminating it from cognitive changes observed in AD and normal aging.
The MCIS may be a valuable tool in the identification of elderly at high risk for dementia due to its ease-of-use and brief administration time.
The MCIS significantly discriminated among aMCI , AD , and healthy elderly controls.
The McMaster Quality of Life Scale covers nine domains.
The McNemar and Kappa tests were also applied.
The MCP-1 levels were significantly different , with the highest levels found in SO participants ( P < 0.05 ) .
The MCT program improved results of functional tests including chair stand and habitual walking speed.
The MCW of men and women ( @number@.17mm and @number@.91mm , respectively , p < @number@ ) was strongly associated with age and MCI.
The MDC varies by sample size.
The MDC was estimated using SEM , based on a test-retest study ( 2-week interval ) and on the anchor-based method.
The MDD cohort comprised @number@ MDD patients and @number@ controls ( aged 20-79 years ) .
The MDR interaction analysis revealed weak synergism between the markers XPD-Asp312Asn and XRCC1-Arg399Gln contributing to cataract.
The MD values of bilateral hippocampi and pallidums , and the relative volume of left pallidum , entered the final model of combination analysis.
The MD values of bilateral hippocampi and pallidums entered the final model of MD analysis.
The Mealtime Audit Tool ( MAT ) is a staff-administered clinical assessment tool to identify FI barriers for individual patients.
The mealtime experience is known to be important in the multifactorial causes of food intake.
The mean 10-year Framingham CVD risk was @number@ ± @percent@ , and @number@ ( @percent@ ) had increased hsCRP.
The mean absolute loss of TASM in these men and women subjects was @number@ and @number@ kg , respectively.
The mean age at baseline was @number@ ± @number@ years.
The mean age at death was @number@ ± @number@ years.
The mean age at diagnosis was @number@ years , and the time lapse between liver transplantation and diagnosis was @number@ months.
The mean age at natural menopause onset was @number@.66±4.44 years , and the median menopause age was @number@
The mean age at onset was @number@.3±15.8 years.
The mean age at onset was @number@ ( SD = @number@ ) years in prospective cases ( N = @number@ ) .
The mean age at the time of operation was @number@ years ( range : @number@ to @number@ years ) .
The mean age at visit @number@ was @number@.2±9.5 years.
The mean age for this group was @number@ years , and @number@ members ( @percent@ ) of the group were female.
The mean age ( mean ± SD ) of the subjects was @number@ ± @number@ years.
The mean age of males in the studies sample was @number@ ± @time@ mean age females was @number@ ± @number@
The mean age of participants was different , and the dosage and frequency of ferrous sulphate differed.
The mean age of participants was @number@ and mean educational attainment was @number@ years.
The mean age of participants were @number@.5±6 years and @percent@ of them did not perform physical activity.
The mean age of patients ( @number@ women , @number@ men ) was @number@ years.
The mean age of patients ( @percent@ male ) was @number@ ( interquartile range [ IQR ] , 35-48 ) years.
The mean age of patients was @number@.72±8.76years.
The mean age of patients was @number@ ± @number@ years ( range 90-100 years old ) .
The mean age of presentation for each finding was < 12 months.
The mean age of respondents was @number@ ± @number@ years ( range , 65-97 years ) , and @number@ ( @percent@ ) were women.
The mean age of respondents was @number@ years and they were predominately female ( @percent@ ) .
The mean age of subjects with each grade of histological changes was calculated.
The mean age of subjects with the histological changes was significantly higher than that of individuals without such changes ( P < @number@ ) .
The mean age of the cohort was @number@ ± @number@ years.
The mean age of the entire sample was @number@.2±7.4 years at baseline.
The mean age of the group was @number@ years.
The mean age of the participants was @number@.3±8.8 years.
The mean age of the participants was @number@.5±13.8 years and ranged from @number@ to @number@ years.
The mean age of the participants was @number@ ± @number@ years.
The mean age of the participants was @number@ years.
The mean age of the participants was @number@ years.
The mean age of the participants was @number@ years ( SD = @number@ ) .
The mean age of the participants was @number@ years ( standard deviation @number@ years ) .
The mean age of the patients varied with sub-site and gender from @number@ years to @number@ years.
The mean age of , the patients was @number@ + / - @number@ years.
The mean age of the patients with endometriosis was @number@ ± @number@ years.
The mean age of the population was @number@ years with roughly equal proportions of males ( @percent@ ) and females ( @percent@ ) .
The mean age of the pt with complications in Poland and in Italy was @number@ and @number@ years , respectively.
The mean age of the recipients was @number@ ± @number@ years , and the mean duration of dialysis was @number@ ± @number@ years.
The mean age of the sample was @number@ years , and @percent@ of participants were female.
The mean age of these trial participants was compared with the mean age of the overall population of incident KTRs in the United States.
The mean age of the study group was @number@ years.
The mean age of the subjects was @number@ years ( range 32-80 ) .
The mean age of women ( @number@ ± @number@ years ) was significantly higher than that of men ( @number@ ± @number@ years ) .
The mean age of women was @number@.67±5 years.
The mean age was @number@.04±7.55 ( 65-108 ) years.
The mean age was @number@.52±3.29years ( range 90-108years ) .
The mean age was @number@.7±4.3 years ( normal subjects ) and @number@.1±5.1 years ( glaucoma patients ) .
The mean age was @number@.7±6.5 years.
The mean age was ( @number@ ± @number@ ) years.
The mean age was @number@ ( @number@ ) years.
The mean age was @number@ ± @number@ years.
The mean age was @number@ ± @number@ years.
The mean age was @number@ ± @number@ years.
The mean age was @number@ ± @number@ years.
The mean age was @number@ ± @number@ years ( age range , 30-75 years ) .
The mean age was @number@ ± @number@ years old with @percent@ of women and @percent@ lived at home.
The mean age was @number@ ± @number@ years , @percent@ of the cohort were aged over @number@ and @percent@ were male.
The mean age was @number@ ± @number@ years , @percent@ were women.
The mean age was @number@ ± @number@ years , @percent@ with a hypercoagulable state , and no sex differences.
The mean age was @number@ ( range 65-82 ) with a mean length of stay of @number@ days.
The mean age was @number@ ( range : @date@ ) years.
The mean age was @number@ ( SD @number@ ) and @number@ of the participants were women.
The mean age was @number@ years.
The mean age was @number@ years.
The mean age was @number@ years.
The mean age was @number@ years ( 17-85 years ) .
The mean age was @number@ years ( 18-89 ) .
The mean age was @number@ years and @percent@ were classified as having hyposalivation.
The mean age was @number@ years and @percent@ were women.
The mean age was @number@ years and the duration of DM was @number@ years.
The mean age was @number@ years and the majority ( @percent@ ) were classified as high dependency.
The mean age was @number@ years , @number@ ( @percent@ ) were female and mean follow up time was @number@ months.
The mean age was @number@ years old.
The mean age was @number@ years old and most of the patients were late elderly.
The mean age was @number@ years ( @percent@ women ) .
The mean age was @number@ years ( range 51-59 ) .
The mean age were @number@ ± @number@ years old , @percent@ were female.
The mean age where mortality reached minimal value was @number@ ( @percent@ confidence interval @number@ @date@ ) years.
The mean allelic frequency observed in the controls was @number@ with higher occurrences in Central European populations ( @number@.006 / 0.008 ) .
The mean ALM was @number@ kg [ standard deviation ( SD ) : @number@ ] .
The mean and median of thyroglobulin were calculated in these subgroups.
The mean and standard deviation of the ADC values of normal testicular parenchyma were calculated for each age group separately.
The mean and standard deviation of the @number@ movement detection thresholds were used to compute a Proprioceptive Acuity Score ( PAS ) .
The mean aorta-sacral promontory measurement based on the CT scan was @number@ mm.
The mean appendicular SMI in the vitamin D group did not change significantly over the 1-year period.
The mean ASA value for the patients in Group-1 was @number@ significantly lower than that in the other groups ( p = @number@ ) .
The mean ASMR decreased from @number@ million person-years in 1987-1989 to @number@ million person-years in 2009-2011 ( @percent@ reduction ) .
The mean BMI was @number@ kg / m ( @number@ ) ( standard deviation @number@ ) and the mean age was @number@ years.
The mean body weights of @number@ g / kg males were significantly less than those of the vehicle controls.
The mean carotid intima-media thickness and cardiometabolic parameters showed no statistically significant findings.
The mean CCI was @number@
The mean CD4 count was @number@ ( 194-1193 ) .
The mean CH and CRF were @number@.6±1.5 and @number@.1±1.6 mmHg , respectively.
The mean change in MMSE score from baseline and reported adverse effects were compared between the two groups.
The mean Cobb angle of kyphosis in the analytic sample was @number@.3° ( standard deviation = @number@ ) .
The mean collagen score significantly increased ( P < 0.05 ) from @number@.53±4.39 to @number@.69±5.46 with @percent@ increment at the end of the treatment.
The mean concentration of each element is compared between different groups.
The mean contractile forces for spontaneous and oxytocin-induced contractions were @number@ ± @number@ and @number@ ± @number@ mN , respectively.
The mean cortical thickness was @number@ ± @number@ mm.
The mean corticomedullary contrast ratio was @number@ ± @number@
The mean cost of the FRIDs intervention was €120 per patient.
The mean cost per hospitalization with primary AF was $ 8 , 819.
The mean costs for Medicare and Medicaid were significantly higher for the patients with schizophrenia than for the patients without schizophrenia.
The mean CPIS ± SD was @number@ ± @number@ in Group A and @number@ ± @number@ in Group B ( P < @number@ ) .
The mean cross-sectional area of the caudate tail was constant across ages despite the varied age range of the subjects.
The mean DDK rate was lower with increased severity of the disease , and was much more severe in patients with moderate AD.
The mean decayed , missing and filled teeth ( DMFT ) score for the study population was @number@
The mean deficit was @number@ ( median : @number@ ) € per patient , range : - @number@ , 470-75 , 144 €.
The mean difference between EGDT and BGDT for all subjects was @number@ msec.
The mean difference between the actual and calculated ages was @number@ and @number@ months , respectively.
The mean differences were greater for free PSA level in the serum for TURP , TRUS-guided prostate biopsy , prostate massage , and rigid cystoscopy.
The mean dose of ritonavir was @number@ mg / day , while the fluticasone dose was @number@ μg / day.
The mean duration of clinical follow-up was @number@ ± @number@ weeks.
The mean duration of follow-up was @number@ months.
The mean duration of treatment was @number@ weeks ( @number@ to @number@ weeks ) .
The mean EBL overall was @number@ cc and the mean operative time was @number@ min.
The mean ED LoS for the 1-h algorithm was @number@.3h-it was @number@.5h for SoC , which is a reduction of @percent@.
The mean energy content of the served food was @number@ ± @number@ kcal per day.
The mean Enneking score , measuring functional outcome , was @number@ out of @number@ ( SD : @number@ range : 16-40 ) .
The mean estimated lifetime costs were $ 130 , 000 after ischemic stroke or intracerebral hemorrhage and $ 80 , 000 after subarachnoid hemorrhage.
The mean extent of wedging was @number@ ± @number@ mm.
The mean FI increased exponentially with age ( r ( @number@ ) = 0.87 ) and was higher in women than in men.
The mean follow-up period lasted @number@ ± @number@ days.
The mean follow-up time was @number@ months.
The mean follow-up was @number@.6±2.4 years.
The mean follow-up was @number@ ± @number@ years.
The mean gain score was high in all the domains of quality of life in the study group at weeks @number@ @number@ and @number@
The mean GCS and mean ISS were @time@ @number@ respectively.
The mean global age at natural menopause ( ANM ) appears robust , suggesting a distinct genetic control.
The mean hair density and thickness were significantly different according to scalp sites.
The mean half-life of ceftaroline in healthy subjects was approximately @number@ hours , and urinary excretion was the primary route of elimination.
The mean HDL level in the 1st and 2nd groups was significantly higher , and triglycerides lower than in the 3rd group.
The mean HDS for IVDs was @number@.1±5.8 and for EP was @number@.2±5.2.
The mean height of brow descending at the midpupil line was @number@ mm ( 0-4 mm ) .
The mean height of lateral brow descending was @number@ mm ( @number@ to @number@ mm ) .
The mean hematocrit level increased significantly from @number@.3±3.4% to @number@.1±3.8%.
The mean hemoglobin A1c was @percent@.
The mean horizontal distance of the brow apex from the midpoint of the pupil for young women was @number@ mm.
The mean hospital length of stay was @time@ + / - @number@ days.
The mean hospital stay in the CCS @number@ group was @number@ d , while in the PPH-01 group the median hospital stay was @number@ d.
The mean hospital stay ( @number@ days ) was not different between the two cohorts.
The mean hospital stay was @number@ days ( standard deviation ( SD ) : @number@ ) .
The mean ICU length of stay was @number@ ± @number@ days.
The mean IIEF-5 ( P = 0.011 ) and IIEF-15 scores ( P = 0.021 ) improved significantly.
The mean increase in BMI z-score during treatment in @number@ patients with pediatric ALL was @number@ ( @percent@ CI : @number@ @date@ ) .
The mean increase in BMI z-score ranged between @number@ and @number@ beyond treatment completion.
The meaningfulness of the masker had a greater detrimental effect on speech understanding for older participants than for younger participants.
The mean initial pain score for those @number@ patients who did receive pain medication was @number@ ( SD = @number@ ) .
The mean interval between the studies was @number@ ± @number@ years.
The mean interval to diagnosis of depression , anxiety , PTSD and personality disorders were @number@ @number@ @number@ and @number@ months respectively.
The mean intervertebral foraminal areas in the control group of C5-C6 and C6-C7 are significantly greater than those of C3-C4 and C4-C5.
The mean intima-media thickness was @number@ mm in diabetics , @number@ mm in hypertensive patients and @number@ mm in controls.
The mean IOP in women was @number@ mmHg higher than in men ( p = @number@ ) .
The mean IOP of men was significantly higher than women ( P = @number@ ) .
The mean IOP of subjects was @number@ ± @number@ mmHg for both eyes.
The mean IOPs of males and females in @number@ were @number@.4±3.1 and @number@.8±2.8 mm Hg , respectively ( P < 0.0001 ) .
The mean IPSS improved from @time@ @number@ ( p < 0.05 ) .
The mean leakage rate and relative leakage volume were calculated using noise-corrected histogram analysis.
The mean length of hospital stay decreased from @number@ days in @number@ to @number@ days in @number@ ( P < @number@ ) .
The mean length of in-hospital stay was @percent@ shorter in the POSH cohort ( @number@ vs @number@ days ; p = @number@ ) .
The mean length of the MDx remained constant with age.
The mean lens power showed a biphasic trend.
The mean level of anxiety and depression as measured by HADS was @time@ + / - @number@ and @number@ + / - @number@ respectively.
The mean level of BMI was @time@ ±3.47kg / m ( @number@ ) and mean SUA was @number@.72±87.01.
The mean level of carbohydrate oxidation rate in the 3rd group of children was lower than normal value ( p < @number@ ) .
The mean level of cerebellar tonsillar related to BO line was @number@ mm.
The mean level of stress was significantly reduced ( @number@.64±4.15 vs @number@.64±3.82 , p < 0.001 ) between baseline and the study endpoint.
The mean levels of essential metals were within the reference values , while the most toxic metals were above them in both groups.
The mean levels of subcutaneous AT were over 2-fold greater than visceral AT in women aged 60-69 years in any BMI stratum.
The mean lifespan of untreated N2 and LB25 was @number@ ± @number@ and @number@ ± @number@ days , respectively.
The mean LOS was @number@ days , and the median LOS was @number@ day.
The mean macular and RNFL thickness were recorded , and the effects of age , gender , and refraction on these parameters were evaluated.
The mean mandibular vBMD was higher in females than males in each age group ( P less than @number@ ) .
The mean maximum amplitude values for spontaneous and oxytocin-induced contractions were @number@ ± @number@ and @number@ ± @number@ mN , respectively.
The mean maximum voice intensity was @number@ dB.
The mean measurements in each group were calculated and compared within each group.
The mean , median , minimum and maximum values for days stayed in hospital were @number@ @number@ @number@ and @number@ respectively.
The mean menopause age of participating women was x = @number@ ± @number@
The mean mirror distance was @number@ cm ( range @number@.5-178 , SD = 42.8 ) .
The mean MMSE score was @number@ ± @number@ ) .
The mean MMSE score was @number@ ( SD = 7.24 ) , and the mean EQ-5D score was @number@ ( SD = 0.34 ) .
The mean normalized and non-normalized EMG activities of erector spinae during the entire task also were calculated.
The mean ( normative ) GWR curves were employed to describe the normal brain and quantify aging and to illustrate pathology detection and characterization.
The mean number of active diagnoses per patient was @number@ ( SD±3.4 ) .
The mean number of calls to physicians per patient decreased from @number@ to @number@ ( p < @number@ ) .
The mean number of chronic diseases was @number@
The mean number of comorbidities and Charlson comorbidity index score were greater in MCI and dementia groups than in control group.
The mean number of criteria for each time-point within each group was compared using a paired Student's t-test.
The mean number of diagnoses per resident was @number@ ( SD : @number@ ) .
The mean number of DRPs per patient at baseline in the intervention group and waiting list combined was @number@ with no difference between the groups.
The mean number of hours individuals reported sleeping was @number@
The mean number of hours of use per day was @number@ hours ( SD , @number@ h ) .
The mean number of meals per day of normal men was significantly higher than of obese men.
The mean number of medicines dispensed was @number@ ± @number@ ( ± SD ) with a @number@ % confidence interval of @number@.63-5.65.
The mean number of nodes removed , by means of ilio-obturator lymphadenectomy , was @number@ ( 13-19 ) .
The mean number of STOPP / START criteria at each time-point was compared for pre- and post-introduction of a pharmacist using a Mann-Whitney U-test.
The mean @number@ OHD level was 53·3 nM ; 47·8% had @number@ OHD levels below @number@ nM.
The mean observation period was @number@ years.
The mean of corneal astigmatism , distribution of astigmatism and the cumulated distribution were calculated.
The mean offset of centre of the acoustic meati from the GL was @number@ cm.
The mean of Kappa coefficient between two examiners was @number@ which was between @number@ and @number@ for various items.
The mean operation time and estimated blood loss were @number@ min and @number@ ml , respectively.
The mean operative time was @number@ minutes.
The mean overall bowel function score was decreased among patients ( @number@ ± @number@ vs @number@ ± @number@ P < @number@ ) .
The mean PA for men was @number@.7° ± @number@.3° ( @number@.4°-9.2° ) , and for women it was @number@.5° ± @number@.7° ( @number@.8-6.0° ) .
The mean participant age was @number@ years ( SD = @number@ ) .
The mean patient age was @number@ years , and @percent@ of the patients were women.
The mean patient quality score was @percent@ ± @percent@ ( range @percent@ to @percent@ ) .
The mean PCS and MCS ( / 100 ) scores were @number@ ± @number@ and @number@ ± @number@ respectively.
The mean percentage of accommodation utilised increased with subject age ( r = 0.517 , p = @number@ ) .
The mean platelet volume was increased in all patients before and after surgery especially in the elder age group.
The mean postimplantation follow-up time was @number@ years.
The mean postoperative decrease in the green : blue ratio was greater in the untinted IOL group ( P = @number@ ) .
The mean pre-operative prostate volume was @number@ cm³.
The mean preparedness and burden scores before and after the program essentially remained the same.
The mean prevalence in Brazil is higher than that found in the rest of the world.
The mean prevalence reported in the articles was @percent@ , but several criteria were utilized to measure self-medication.
The mean progression time of psychotic or affective transformation was @number@ to @number@ years.
The mean rate of myopic shift also decreases with age.
The mean rates of polypharmacy > 5 drugs and polypharmacy > 7 drugs were @percent@ and @percent@ , respectively.
The mean reaction time and three measures of intra-individual reaction time variability were calculated separately across @number@ trials of simple and choice reaction time tasks.
The mean reaction time had no significant association with mortality.
The mean reading grade level for all user guides was grade @number@ which is too high for older adults.
The mean relative volumes and mean MD values of subcortical gray matter structures were compared between early-stage AD and control groups.
The mean resected tissue weight was @number@ g.
The mean RV IVAc was @number@ m / sec ( @number@ ) ( ±2 SD : @number@.1-3.6 m / sec ( @number@ ) ) .
The mean S2-S4 distance was @number@ cm for group @date@ @number@ cm for group II , and @number@ cm for group III.
The mean score for ERA ( possible range = 0 to @number@ ) was @number@.04± @time@ .
The mean score of burden was 28±12.75.
The mean score of quality of life was ( @number@ ± @number@ ) .
The mean score of spiritual attitude was @number@.77±6.20.
The mean score of spiritual well-being was ( @number@ ± @number@ ) .
The mean score on the measure of purpose was @number@ ( SD , @number@ range , @number@.1-5.0 ) .
The mean score on the scale was @number@ ( range 3-9 ) , indicating relatively low levels of loneliness.
The mean scores for each domain increased from the premenopausal period through the postmenopausal period ( P for trend < @number@ ) .
The mean scores obtained were @number@ ( group @number@ ) and @number@ ( group @number@ ) .
The mean ( ±SD ) age at baseline was @number@ ± @number@ y.
The mean±SD age in the prevalent CMC1 cohort ( n = 11 , 111 ) was @number@.7±11.4 years ; @percent@ of diagnoses were in women.
The mean ± SD age of the @number@ patients with potential DDIs was @number@ ± @number@ years , and @percent@ of these patients were male.
The mean ( SD ) age of the participants was @number@ ( @number@ ) years and @percent@ were women.
The mean ( ±SD ) age of the patients was @number@.1±2.1 years.
The mean , S.D. and @percent@ limits of agreement of ADC values for each age-defined group are reported.
The mean ( SD ) BMD change was @percent@ per year ( @percent@ ) .
The mean ( ±SD ) delay in conception was @number@.5±2.6 months.
The mean ± SD duration of implantation was @number@ ± @number@ months ( range @number@ days-8 years ) .
The mean ( SD ) follow-up lasted @number@ ( @number@ ) years.
The mean ± SD number of daily classes of drugs received at admission was @number@ ± @number@ ( median @number@ range 0-20 ) .
The mean±SD surrogate age was 57±10 years , and @percent@ were nonwhite.
The mean size of the resected specimens was @number@ mm ( range 8-80 mm ) .
The mean social contact score was @number@ ± @number@
The means of EMPs were @number@ ± @number@ @number@ ± @number@ and @number@ ± @number@ in groups A , B and C , respectively.
The means of EPCs were @number@ ± @number@ @number@ ± @number@ and @number@ ± @number@ in groups A , B and C , respectively.
The mean spherical equivalent values was hyperopic until @number@ y / o and decreased slightly as the population ages.
The mean ( standard deviation ) HAS was @number@ ( @number@ ) in men and @number@ ( @number@ ) in women.
The mean ( standard deviation ( SD ) ) age of the sample was @number@ ( @number@ ) years.
The mean strength was reduced for all materials after immersion in the fluid.
The mean subfoveal CT in right eyes was @number@ ± @number@ µm.
The mean surgery time was @number@ minutes ( 180-420 ) .
The mean survival time of ALS cases from first paresis was @number@ months.
The mean T2 relaxation time and thickness of the patellar cartilage were documented for each MRI examination.
The mean Teller acuity was @number@ cycles per degree ( range @date@ @number@ SD = 2.8 ) .
The mean telomere length in peripheral blood leukocytes was measured by quantitative real-time PCR.
The mean telomere length in the leukocytes of PCOS patients was comparable to that of control individuals who were on average @number@ years older.
The mean temporal delays corresponding to peaks in inter-regional transfer entropy are computed and used as features to discriminate between the three groups of participants.
The mean test duration was not significantly different between the tests ( p = @number@ ) .
The mean testosterone level was calculated for patients aged < 50 years and was compared with the mean value of patients aged ≥50 years.
The mean time delay between the diagnosis of neurodegenerative diseases and onset of skin lesions is @number@.17years.
The mean total cost of care was @number@ ± @number@ € ( range : @number@ to @number@ € ) .
The mean total costs were €2176.77 for the intravenous infusion and €1911.09 for the subcutaneous injection.
The mean total score was @number@ out of a maximum of @number@
The mean total testosterone level was @number@ ± @number@ ng / dL.
The mean total volume of Voluma injected was @number@ mL / patient.
The mean value of coefficient K characterizing this contribution in healthy group was positive and increased from preschool age till adolescence.
The mean value of coefficient K in cecutient children was negative or near zero.
The mean value of GHQ12 significantly decreased as the HPI increased by adjusting age.
The mean value of IMT was @number@ ± @number@.1mm , which was lower than the normal value ( @number@.0mm ) in adults.
The mean value of the 180-degree peel strength of the orthodontic acrylic resin group was found to be lower ( P < .05 ) .
The mean value of the orthodontic acrylic resin subgroup peel bond strength was found to be statistically lower ( P < .05 ) .
The mean values of early and delayed SUVmax of Schmorl's nodes with MRI enhancement were @number@ ± @number@ and @number@ ± @number@
The mean values of IL-1β , TNF-α , IL-6 and CCL5 values were @number@ @number@ @number@ and @number@ pg / mL , respectively.
The mean values of PI were significantly greater for these cases.
The mean velocity during normal walking was @number@.9±20.6cm / s , and the mean cadence was @number@.1±9.9 steps / min.
The mean ventricular temperature was determined from the distribution function of the temperature of all selected voxels.
The mean volume of filler used was @number@ ml / eyelid ( range , @number@.1-1 ml ) .
The mean volume of SGP-HA required for optimum NLF correction decreased substantially with each retreatment.
The mean VSQ score for GP and MS groups was @number@ and @number@ ( P < @number@ ) , respectively.
The mean white hair percentages were @number@ ± @percent@ in males and @number@ ± @percent@ in females.
The mean white hair percentages were significantly increased in subjects over @number@ years of age.
The mean within-subject VAS difference was @number@ mm.
The mean years of potential life lost was @number@ years.
The mean Δ MDRD and C-G was @number@ ( @percent@ limits of agreement @number@ and @number@ ) .
The measured effect of selection increased exponentially with increasing pathogenicity score.
The measured PTH was normalized according to S1W and age of the subjects , allowing the comparison among anatomies of different sizes.
The measurement of appendicular lean mass ( ALM ) may distinguish those at higher versus lower risk of poor outcomes.
The measurement of APV is an easy and practical new echocardiographic method and may be used to identify arterial stiffness in these patients.
The measurement of carotenoids in human skin was performed in vivo using resonance Raman spectroscopy.
The measurement of lower back mobility is essential in the assessment of lower back pain including ankylosing spondylitis.
The measurement of PNIF could be useful in evaluating elderly patients who complain of nasal obstruction.
The measurement of ROS markers in the rat experiments was consistent and supported human study data.
The measurement of serum AMH levels during woman's reproductive life represents an ideal tool for the assessment of the ovarian follicular reserve.
The measurement of the maximally elevated point of the hyoid bone decreased with age.
The measurements are highly suited for the development of anti-ageing strategies and can be efficiently used in the medical diagnostics and therapy control.
The measurements are performed in triplicate and the average is used for analysis.
The measurements can be taken from those already existing for the general population or be specifically designed for the visually impaired population.
The measurements made using ARTSENS showed strong correlation with those made using the imaging system.
The measurements of the network properties were calculated for each of the three groups respectively.
The measurements were carried out before each of the @number@ retinol peel treatments applied at 3-week interval and @number@ weeks after the last treatment.
The measurements were compared according to age , sex , and dentition.
The measurements were performed before and after aging.
The measurement was conducted for @number@ hours.
The measure of absolute , or fixed , poverty was based upon the US poverty threshold.
The measures of efficiency and variability ought to be considered as complementary since they convey specific information on the organization of control processes.
The measures of physical performance included hand-grip strength , the five-times-sit-to-stand test , and walking speed.
The measures were repeated at three and six months.
The measuring instruments used were the Barthel Index and a semi-structured interview.
The mechanical model treats the lens as an axisymmetric object , and the optical model incorporates a gradient refractive index.
The mechanical obstruction , along with the direct action of the unfavorable metabolic and hormonal milieu on the bladder neck , helps in generating LUTS.
The mechanical properties of pulmonary tissues are important in normal function and the development of diseases such as pulmonary arterial hypertension.
The mechanical properties of skin are determined primarily by the extracellular matrix of the dermis.
The mechanical properties of the aorta affect cardiac function and are related to cardiovascular morbidity / mortality.
The mechanical properties were evaluated by tensile tests during aging.
The mechanical results were converted with respect to the diameter and Stress-Strain curve was obtained for each sample.
The mechanical stimulus thus evoked an anti-aging response.
The mechanism attributable to acquired resistance harbors evolution of neoantigen landscape , mutations of JAK and β-2-microglobulin , and epigenetic stability of exhausted T cells.
The mechanism behind the antioxidant activity of prolactin remains elusive.
The mechanism behind these comorbidities is chronic excessive inflammation induced by HIV infection , which persists under antiretroviral therapy.
The mechanism behind this novel finding and its implications require further study.
The mechanism by which all these signals are coordinated to yield a final response is not well understood.
The mechanism by which amyloid-β ( Aβ ) produces brain dysfunction in patients with Alzheimer's disease is largely unknown.
The mechanism by which CENP-A declines appears to be post-transcriptional , as there was no correlation between CENP-A mRNA levels and age or islet purity.
The mechanism by which the human KL-VS variant affects cognition also requires further elucidation.
The mechanism by which the three-dimensional extracellular matrix confers the MMP genes into an epigenetically permissive state has not been well characterized.
The mechanism by which this occurs is not well understood , but might be related to impairments in several key immunoregulatory systems.
The mechanism for the bonding between zirconia and veneering ceramics remains unknown.
The mechanism for this association remains unknown and requires further research , including studying the potential role of GGT in oxidative stress.
The mechanism for this failure of vaccine response in HCV-infected subjects remains unclear.
The mechanism involved may be related with TGF secretion and decrease of collagen degradation.
The mechanism involves selective association of the active enzyme with transcriptionally active nucleoids and a direct interaction with mitochondrial RNA polymerase.
The mechanism linking poor quality with high DON quit intentions is an area for future research.
The mechanism might be related to increasing TGase-1 expression and activity.
The mechanism of activation was described in @number@ studies ( @percent@ ) , while anticoagulation was uncommonly elucidated ( @percent@ ) .
The mechanism of antiplatelet action of CDA could be by NF-κB inhibition and that is cAMP independent.
The mechanism of cellular aging likely involves decreased telomere length and is associated with age-related diseases such as cardiovascular disease.
The mechanism of declining NAD + levels and its fundamental importance to aging are yet to be elucidated.
The mechanism of senescence is not atavism from which we should escape but the achievement of evolution without which the humanity cannot exist.
The mechanism of Sirtuin modulation by resveratrol is not well understood.
The mechanism of such age-specific host restriction remains unknown.
The mechanism of these differences due to either genetics or age is not known but can be investigated in strain- and age-specific infectious disease models.
The mechanism of this enhancement needs further investigation and its elucidation should advance COPD management.
The mechanism of this inhibitory effect on growth and invasion / migration was Ras inactivation through disrupting the p190-A RhoGAP / p120RasGAP complex.
The mechanism of this result could not be elucidated by cell proliferation , migration and invasion assays.
The mechanisms affecting epidermal homeostasis during aging remain poorly understood.
The mechanisms and triggers underlying these functional activation and connectivity changes remain to be investigated.
The mechanisms behind aberrant DNA methylation have long remained obscure.
The mechanisms behind stress-induced AD or dementia are not known.
The mechanism ( s ) behind the apparent sexual dimorphism warrants further study.
The mechanisms by which aging and other processes can affect the structure and function of brain networks are important to understanding normal age-related cognitive decline.
The mechanisms by which air pollution has multiple systemic effects in humans are not fully elucidated , but appear to include inflammation and thrombosis.
The mechanisms by which the risk increase is transported are still unknown.
The mechanisms for adaptation involve a multistep process of cellular mechanotransduction stimulating bone modelling , and remodeling resulting in either bone formation or resorption.
The mechanisms involved in intrinsic and extrinsic ( photo- ) aging are described.
The mechanisms involved in this association include pathways , greater adherence to healthy behaviors and diverse social factors.
The mechanisms involved in this phenomenon are not yet clear and merit further investigation.
The mechanisms leading to frailty typically involve several systems : mainly hormones , oxidative stress , inflammation , immunity , and vascular system.
The mechanisms leading to these changes are poorly understood.
The mechanisms linking fetal smoke exposure with cardiovascular risk factors in later life may include other mechanisms than structural microvasculature adaptations.
The mechanisms linking indicators of religious involvement with indicators of cellular aging are also undefined.
The mechanisms of action involve induction of intracellular cAMP , activation of PKA and MAPK pathways and phosphorylation of CREB.
The mechanisms of both transcriptional repression and activation of Arf are not understood.
The mechanisms of mitochondrial genome damage in the development of chronic age-related diseases such as atherosclerosis are not yet well understood.
The mechanisms of mitochondrial lipid trafficking are only now emerging and appear to involve membrane contact sites and lipid transfer proteins.
The mechanisms of neuroprotection are diverse and include both neuronal and vascular pathways.
The mechanisms of stem cell aging and its real contribution to human aging remain to be defined.
The mechanisms of this photodamage to all layers of the skin by the various wavelengths ( UVB and UVA ) will be clarified.
The mechanisms of vascular control of thrombotic events remain unclear.
The mechanisms regulating incretin secretion are not fully known.
The mechanisms regulating neutrophil apoptosis are basically unaffected by the aging process.
The mechanisms responsible for postmenopausal hypertension have not been completely elucidated.
The mechanisms responsible for the changes in basal post-absorptive protein turnover and its impact on muscle hypertrophy following resistance exercise training are unknown.
The mechanisms responsible for this deterioration , however , remain poorly understood.
The mechanisms that account for this phenomenon are incompletely known , but it is becoming clear that longevity genes might be involved.
The mechanisms that regulate the aging epigenome and level of conservation are not entirely clear.
The mechanisms through which diabetes is assumed to promote oncogenesis include insulin resistance and associated hyperinsulinemia , hyperglycemia , and inflammation.
The mechanisms through which these fetal events affect adult testosterone levels are largely unknown.
The mechanisms underlying aggregate formation in age-related neurodegenerative diseases remain not well understood.
The mechanisms underlying DHF include abnormal matrix dynamics , altered myocyte cytoskeleton , and impaired active relaxation.
The mechanisms underlying DM-related changes in LTD and LTP inductions are still unknown.
The mechanisms underlying primary and acquired resistance to PD-1 / PD-L1 blockade have remained ambiguous.
The mechanisms underlying ryanodine receptor ( RyR ) dysfunction associated with Alzheimer disease ( AD ) are still not well understood.
The mechanisms underlying the age-related endothelial , smooth muscle and extracellular matrix vascular dysfunction are discussed.
The mechanisms underlying the cognitive-frailty link are multi-factorial , and vascular , inflammatory , nutritional , and metabolic influences may be of major relevance.
The mechanisms underlying the preferential vulnerability of nigrostriatal dopaminergic neurons in PD remain poorly understood.
The mechanisms underlying the relations among health literacy , perceived capacity for communication , diabetes knowledge , and diabetes self-care are unclear.
The mechanisms underlying these benefits remain unknown although it has been suggested that exercise-induced changes in the circadian pattern of cortisol secretion may be implicated.
The mechanisms underlying these relationships may be differentially related to specific neuroelectrical processes involved in neurocognitive control.
The mechanisms underlying this effect remain hotly debated.
The mechanisms underlying this process are thought to be an age-related decrease in activation extent as well as an increased magnitude in task-related areas.
The mechanisms underpinning and the impact of these changes are not well understood.
The mechanisms underpinning these improvements come from comparable and diverse pathways.
The mechanism through which social support is associated with poorer cognitive function in some domains deserves further exploration.
The mechanism underlying this apparent protective effect warrants further study.
The mechanism underlying this association is not known.
The mechanism underlying this compensation is still poorly understood.
The mechanism whereby cholesterol metabolism functionally impacts neurodegeneration induced by α-synuclein is undefined.
The mechanistic background concerning how bilirubin and its metabolism may influence disease prevention and its clinical relevance is also discussed.
The mechanistic cause of this observation is not well established.
The mechanistic link between the aging process and disease pathogenesis , however , is still enigmatic.
The mechanistic target of rapamycin ( mTOR ) coordinates eukaryotic cell growth and metabolism with environmental inputs , including nutrients and growth factors.
The mechanistic target of rapamycin ( mTOR ) pathway is crucial for life span determination in model organisms.
The medial entorhinal cortex ( MEC ) contains specialized neurons called grid cells that form part of the spatial navigation system.
The medial temporal lobe is implicated as a key brain region involved in the pathogenesis of Alzheimer's disease ( AD ) and consequent memory loss.
The medial temporal lobe ( MTL ) is the first brain area to succumb to neurofibrillary tau pathology in Alzheimer's disease ( AD ) .
The median 25 ( OH ) D level was @time@ Quartile Range = 26.08 ) .
The median age at death is @number@
The median age at diagnosis is nearly @number@ years.
The median age at diagnosis is @number@ years , yet older patients are under-represented in clinical trials.
The median age at diagnosis was @number@ months.
The median age at diagnosis was @number@ years ( range @number@ to @number@ years ) .
The median age at transplantation was @number@ years , and the median age at the diagnosis of prostate cancer was @number@ years.
The median age is @number@ years.
The median age of HIV-infected patients is increasing all over the world.
The median age of Namibian transfusion recipients was @number@ years ( SD , ±19 ) .
The median age of participants was @number@ years ( range , 48-96 years ) .
The median age of patients was @number@ ( interquartile range 76-87 ) and @percent@ were women.
The median age of the AF patients increased from @number@ to 71years ( p < 0.001 ) .
The median age of these @number@ patients was @number@ years ( range 60-88 years ) .
The median age of this population was @number@ years , with @percent@ being male.
The median age was 75·4 ( 69·8-81·2 ) years , and the median osteocalcin level was 1·8 ( 1·3-2·4 ) nmol / l.
The median age was @number@ ( range 19-93 ) .
The median age was @number@ years , and @number@ % were women.
The median age was @number@ years ( interquartile range [ IQR ] 69-80 ) , @percent@ were women and @percent@ had OAB syndrome.
The median age was @number@ years ( interquartile range [ IQR ] @number@ @number@ ) .
The median age was @number@ years ( interquartile range : @number@ ) .
The median age was @number@ years ( IQR @number@.6-74 ) .
The median age was @number@ years , with @number@ % females.
The median AKI diagnosis time , presence of oliguria , uric acid level , and a more severe AKI stage were associated with delayed consultation.
The median amyloid PET was low until age @number@ years and increased thereafter.
The median and mode for natural menopause were @number@ and @number@ years of age , respectively.
The median article had @number@ patients.
The median CFSEI-2 score for both healthy and diabetic children was @number@
The median Cutometer readings ranged from @number@ to @number@ percent of the control values.
The median delay in onset of the Emax was @number@.5h ( @number@.33-15 ) in nordiazepam and 4h ( @date@ ) in oxazepam overdose.
The median disease-free survival time was @number@ mo for the young group and @number@ mo for the old.
The median duration of follow-up was @number@ years ( range : @number@ months to @number@ years ) .
The median eminence at the base of the hypothalamus serves as an interface between the neural and peripheral endocrine systems.
The median ESI was @number@ ( interquartile range : @number@ @number@ ) g / day.
The median follow-up time was @number@ years.
The median follow-up was @number@ years.
The median glomerular filtration rate was @number@ mL / min / m².
The median healthy life span of creatine-fed mice was @percent@ higher than in their control littermates , and they performed significantly better in neurobehavioral tests.
The median initial prostate-specific antigen level was @number@.4ng / ml.
The median ( interquartile range ) age on procedure date for the octogenarian cohort was @number@ ( @number@ ) years.
The median ( interquartile range ) number of drugs was @number@ ( 1-4 ) ; @percent@ of subjects reported regular use of ≥5 drugs.
The median ( IQR ) age of patients was @number@ ( 77-86 ) years.
The median ( IQR ) age was @number@ ( 70-78 ) .
The median ( IR ) CPAP daily usage was @number@.3 ( @number@ @number@ ) h / day.
The median length of follow-up was @number@ years.
The median length of stay in the hospital was @number@ [ 3-6 ] days.
The median Mini Mental State Examination score was @number@ ( IQR @number@ @number@ n = @number@ ) .
The median MRS score was higher for HIV-positive compared to HIV-negative women ( p = @number@ ) .
The median number of BG per patients in target range increased from @number@ ± @number@ to @number@ ± @number@ ( p < @number@ ) .
The median number of ideal CVH metrics was @number@ and no participant met all @number@
The median number of injections before the MH formation was @number@
The median number of prescribed drugs was @number@ per resident during the two period of study.
The median numbers of patients with hypogonadism-related symptoms per month were @number@
The median of astigmatism was @number@ D ( @number@ @date@ D ) .
The median of BMI was @number@ kg / m2.
The median of metabolic scores and Gal-3 levels were @number@ ( @number@.3-5.2 ) and @number@.8ng / mL ( @number@.7-100ng / mL ) , respectively.
The median of the lying down duration was @number@ hours and @number@ minutes.
The median of the physical activity duration was @number@ hour and @number@ minutes , and in most cases it was the moderate physical activity.
The median OS was @number@ months and the median PFS was @number@ months.
The median overall survival and cause-specific survival for the cohort receiving treatment was @number@ and @number@ months , respectively.
The median overall survival was @number@ months.
The median pain scores during the initial and final treatments were @number@ and @number@ respectively , on a scale of 0-5.
The median percentage of items addressed was @percent@ ( interquartile range 4-100% ) .
The median PFS of RCT arm was significantly longer than that of RT arm ( @number@ vs. @number@ months , p = @number@ ) .
The median preoperative Glasgow coma scale score was @date@ ( range 3- @date@ ) .
The median progression-free survival was @number@ months and the median overall survival was @number@ months.
The median ( range ) LOS was @number@ ( 1-117 ) days.
The median ( range ) total time spent on teaching in ageing and geriatric medicine was @number@ ( 26-192 ) h.
The median rate of laparoscopic cholecystectomy varied between @number@ and @number@ operations per @number@ inhabitants.
The median rate of lesion growth was @number@ cm ( @number@ ) per year.
The median RNA Integrity Number ( RIN ) for frozen brain and body tissue is @number@ and @number@ respectively.
The median sample size was @number@ participants.
The median score on @number@ questions was @number@ of @number@
The median SITT were @number@ min for females and @number@ min for males.
The median survival of elderly glioblastoma patients is generally inferior to @number@ months.
The median survival times of the three groups were @number@ @number@ and @number@ months ( P < @number@ ) .
The median survival times of the three groups were @number@ @number@ and @number@ months ( P < @number@ ) .
The median survival was longer in surgical patients than in those receiving conservative therapy ( 8-34 vs 4-5 weeks ) .
The median time from AML diagnosis to death was @number@ months.
The median time from the diagnosis of HCV infection to the end of follow-up was @number@ years ( IQR @date@ @number@ years ) .
The median time of abdominal pain in the intent-to-treat ( ITT ) population was @number@ h for racecadotril and @number@ h for loperamide.
The median time of renal recovery was @number@ days ( range , 1-180 days ) .
The median time since primary blepharoplasty was @number@ years ( range , @number@ to @number@ years ) .
The median time spent in the ICU post-operatively was @number@ days.
The median time spent walking was @number@ min per day.
The median time to tumor recurrence was @number@ months.
The median total burden did not differ by serostatus ; however , a subset of HIV + individuals had high WMH burden.
The median total volume of IDs was 40mm3 , inter-quartile range ( IQR ) = 196.
The median waiting time was @number@ seconds ( range , 2-5344 ) .
The median weighted kappa coefficients square for the individual items was @number@
The media thickness of the thoracic aorta progressively increased with age , associated with hypertrophy of vascular SMCs.
The mediation analysis shows that inhibition and flexibility operate as a mediator in the negative relationship between age and the laboratory time-based task.
The mediator variables were organizational , non-organizational and intrinsic religiousness.
The medical community tried , and failed , to resolve these differing definitions several times at consensus conferences and through published articles.
The medical literature has come primarily from oncology.
The medical management of inflammatory bowel disease ( IBD ) in the older patient extends beyond luminal disease activity.
The Medical Outcomes Study 36-Item Short Form Health Survey ( SF-36 ) was used to assess health-related quality of life.
The medical profession is intricately involved in this process because eligibility for consideration for compassionate release is generally based on medical evidence.
The medical records of individuals residing in Santa Catarina aged≥60 years were obtained from the Hospital Information System of the Brazilian National Health System.
The medical records of @number@ consecutive cancer patients starting chemotherapy from @date@ up to @date@ were identified.
The Medical Research Council ( MRC ) provides a framework for a systematic step-wise approach to the evaluation of complex interventions.
The medical system must respond to the evolving needs of this aging and growing older adult population who will dominate the epidemic.
The medication suppresses the endogenous sex-hormone production and brings about the desired features of the other sex.
The medicinal approaches are not always effective.
The Mediet reflects food patterns typical of Mediterranean regions , where olive oil plays an essential role in the food pyramid.
The Mediterranean diet is currently considered a functional diet with an increasing amount of scientific evidence that supports its beneficial effects in human health.
The medium constituents therefore impact the efficacy of ADSC.
The medium-intensity InSTEP model significantly ( p = @number@ ) reduced self-reported falls in comparison with the other models.
The medium was changed to @percent@ FBS @number@ h before treatment.
The MEDLINE database was searched with the following terms : ( gingival OR mucoperiosteal ) AND fibroblast AND ( wound healing OR repair ) .
The meeting organized by LVMH Recherche was centered on the theme of skin rejuvenation.
The megalin receptor has also been implicated in the pathogenesis of AD.
The Mehl-Avrami-Johnson ( MAJ ) theory was applied , which allowed modeling the micromechanisms of nucleation and growth of monoclinic sites during the transformation process.
The MEK inhibitor , U0126 , blocked both PMA- and anti-IgM-induced upregulation of TβRII.
The melanocyte stem cells of the hair follicle provide an attractive system for the study of the stem cells.
The membrane-bound INSR regulates the insulin and IGF1 signaling ( IIS ) pathway and thereby defines metabolism and aging.
The membrane-bound phospholipid ( PL ) hydroperoxides escape detoxification by the lens enzymatic reduction.
The membrane fluctuations showed decreased amplitudes during shape transition from discocytes to spherocytes.
The memory and cognitive impairment of the elderly can be the target of research to prevent development of dementia.
The Memory for Names test was found to measure the same cognitive construct as the Boston Naming Test.
The Memory Impairment Screen ( MIS ) was administered to each participant annually.
The meniscus is a critical tissue in the healthy knee joint because of its shock absorption and load distribution properties.
The menopausal state predisposes to metabolic syndrome and type @number@ diabetes , and therefore the effects of SERMs on metabolic homeostasis are gaining attention.
The menopausal transition increases susceptibility to metabolic diseases such as obesity , diabetes , cardiovascular disease , and cancer.
The menopausal transition is associated with an increased risk of future cardiovascular morbidity and mortality , irrespective of chronological age.
The menopausal transition ( MT ) is the time in each woman's reproductive life that precedes the final menstrual period ( FMP ) .
The menopausal transition precedes menopause by several years and is usually characterized by irregularity of the menstrual cycle and by hot flashes and night sweats.
The menopause transition is a dynamic process that begins with the first appearance of menstrual irregularity and ends with a woman's final menstrual period.
The mentioned measures , increased inclusion rates but also caused an increased time investment and consequently extra financial resources for staff costs.
The menus of Japanese foods from @number@ different years , @number@ @number@ @number@ and @number@ were prepared , cooked , and powderized.
The men were followed @number@ years on average.
The men were selected from couples attending an infertility clinic , who had tried for @number@ months or more to achieve pregnancy without success.
The men with MS showed statistically significant higher Zn and lower Mg concentrations.
The MeP adduct is considered a sign of \ "aging \ " and results in loss of the o-alkyl identifier specific to each nerve agent.
The merits of such measurements as a basis for making clinical decisions still need to be explored.
Themes emerged about perceptions of the health effects of work and coping strategies.
Themes emerged across studies regarding receptivity to completing ASA24 , user experiences with the interface , and practical considerations for different populations.
Themes emerged in relation to preferences and expectations about the technology and how it fits into daily routines.
Themes further distilled into optimal descriptive characteristics of patient-centered providers that may best support older adults ' healthy aging.
The mesh was placed fixation-free and secured in place through the friction exerted by the tentacles.
Themes on structure of social relations , social support , and negative aspects of social relations emerged clearly from the interviews.
The message gleaned from research has been one of greater decline in abilities to recognize specific negative emotions than positive ones.
Themes were discussed in the context of an ethic of care.
Themes were examined across nurse demographics , institutional and unit characteristics.
Themes were searched for function.
Themes were then refined and further detailed.
The meta-analyses results suggested no significant association between the A-670G polymorphism and AD in any genetic models.
The meta-analysis based on uncontrolled studies showed significant heterogeneity among all included studies.
The meta-analysis confirmed that the baseline differences between the two groups were balanced.
The meta-analysis included @number@ studies with a total of @number@ older adults.
The meta-analysis resulted in a list of @number@ suggestive genome wide significant SNPs in or near @number@ genes.
The meta-analysis supported the association between Neuroticism and Conscientiousness and cognitive decline.
The metabolic changes underlying these phenotypes have been poorly characterized , and whether homeostasis is achieved during hospital stay is unclear.
The metabolic diversity of the tissues that are affected by excessive carbohydrate intake suggests that dietary carbohydrate quality may affect cellular homeostasis.
The metabolic drug-drug interaction potential of apixaban was evaluated in vitro.
The metabolic efficiency of N-acetyltransferase @number@ ( NAT2 ) required for the metabolic activation of such amines is influenced by genetic variation.
The metabolic profile in transformed cells is altered to accommodate their fast proliferation , confer resistance to cell death , or facilitate metastasis.
The metabolic state was further characterized in fasting blood samples.
The metabolic syndrome , if unchecked , quickly advances to outcomes that include diabetes , hypertension , cardiovascular disease , and obesity.
The metabolic syndrome is a cluster of risk factor for diabetes and cardiovascular diseases.
The metabolic syndrome is becoming increasingly prevalent in the general population and carries significant incremental morbidity and mortality.
The metabolic syndrome ( MetS ) presents an increasing prevalence in elderly people.
The metabolic syndrome pandemic reflects poor cardiometabolic health due to sedentary lifestyles and excess caloric intake over the background of an aging population.
The metabolic syndrome was defined using the International Diabetes Federation criteria.
The metabolic syndrome was present in @number@ of @number@ patients over @number@ years of age.
The metabolism of these glycated proteins is not yet understood , and the mechanisms that reduce their accumulation are not known so far.
The metabolite biomarkers attenuated the association between hsCRP and MI , indicating a potential link to systemic inflammatory processes.
The metabolite levels were compared with observed age-related changes among the groups.
The metabolite pattern of the MRJPs-fed aged rats was regressed to that of the young rats.
The metalloproteinase-1 ( MMP-1 ) expression was used as a surrogate marker for dermal aging and the involved regulatory mechanisms were explored.
The meta-regression may have identified the causes of heterogeneity as the intervention method , comparator and trial design.
The meta-regression showed that duration of follow up was not associated with changes in cognitive estimates ( β = @number@ p = @number@ ) .
The method also allows investigation of factors that are secreted by myenteric tissue in vitro.
The method combines a senescence-associated beta-galactosidase assay with staining of molecular markers for cellular senescence and of cellular identity.
The method comparison between Minicare cTnI and Beckman Coulter Access , AccuTnI + 3 demonstrated a correlation coefficient of @number@ with a slope of @number@
The method consists of three phases : theory , fieldwork , and analysis.
The method developed by Murtagh et al. was used to give a population-based palliative care needs estimate , encompassing generalist and specialist palliative care need.
The method developed herein represents a powerful tool for analyzing Pls , which may provide a better understanding of their physiological roles in vivo.
The method first determines the location of the macula , which is used as a landmark for a clinical drusen grading overlay.
The method involved review of the pertinent published literature.
The method is applicable for evaluation of free human Achilles tendon mechanical properties in relation to training , injury and rehabilitation.
The method is based on the determination of selected carbonyl compounds called as \ "aging indicators \ " , which are formed during beer aging.
The method is subsequently applied in investigating the influence of age and gender on the human amygdala and hippocampus shapes.
The method might help researchers and clinicians alike in understanding risks for and extent of human diseases.
The method of fracture fixation , soft tissue closure , patient demographics , complications and mortality were recorded.
The method of iterative congruence of search of parameters of kinetic mathematical model of aging of living systems according to medical statistics is developed.
The method of research mainly being empirical , it is preceded by theoretical and literature review.
The method of the approach is qualitative and consists of multi-case study.
The methodological quality of each study was assessed using the Quality of Reporting of Observational Longitudinal Research checklist.
The methodological quality of studies was assessed using the PEDro scale.
The methodological quality of the included trials was generally low.
The methodological quality of the indicator sets varied considerably.
The methodological quality of the meta-analyses was moderate.
The methodological quality of the QI sets was assessed with the Appraisal of Indicators through Research and Evaluation ( AIRE ) instrument.
The methodological quality of the studies varied.
The methodological variation was relatively low in all four methods ( 4-11% ) .
The methodology and findings of these studies were critically reviewed and discussed.
The methodology appears generally applicable in AD modeling.
The methodology developed in our previous studies ( Brochu et al.
The methodology is used to analyze a hearing loss study.
The methodology provided a step-by-step process to unravel a complex problem.
The methodology used in this study may provide a useful model for similar investigations into other balance training approaches.
The methodology used varied widely between studies.
The method requires ∼20 ng of DNA per assay.
The methods are illustrated using data from a population-based longitudinal study of ageing , the Cambridge City over @number@ Cohort Study.
The methods differed in detection of psychomotor features and time of onset.
The methods employed encompassed clinical examinations , fundus photography , indirect ophthalmoscopy , Farmsworth-Munsell @number@ hue discrimination testing and Illumina BeadChip analyses.
The methods included voxel-based analysis with and without smoothing , two types of region-based analysis , and combinations thereof with skeletonization.
The methods include semi-structured interviews with residents and caregivers , and participant observation.
The methods used to achieve it are also based generally on highly expensive measurement devices.
The methods were evaluated with respect to scan-rescan reliability and an application to normal aging.
The method used to learn routes may also influence performance.
The method utilizes an antibody-free enrichment step and isotope-labeled physiologically relevant lipoprotein particle standards produced by immortalized astrocytes.
The method was based on a cross-modal priming paradigm with familiar bimodal items.
The method was compared to the FreeSurfer segmentation tools.
The method was fully validated for use with human plasma samples and was linear from @number@ nmol / ml to @number@ nmol / ml.
The method was then employed with a THA cohort to assess pre- and postsurgical differences in their healthy and operative legs.
The method we use is an extension of the symbolic mapping procedure originally proposed for permutation entropy.
The method will be implemented as part of the popular neuroimaging package FreeSurfer.
The methylation levels at @number@ CpGs differed significantly between healthy and osteoporotic women at @percent@ false discovery rate ( FDR ) .
The methylation levels of six genes were found to correlate with alcohol consumption.
The methylation of RARβ2 gene promoter is a common molecular event in prostate cancer.
The methylmercury content of large , long-lived fish such as swordfish , shark , tuna or marlin , is higher.
The MET mutation was further observed to abrogate the ERBB3-mediated AKT signal transduction , which is shared downstream by EGFR.
The MetS cluster score used the average of deviates of the MetS components standardized to their means and standard deviations at mean age @number@
The MetS definition captures clustering of risk factors that predict higher risk for diabetes mellitus and cardiovascular disease.
The MetS group had much weaker serum antioxidant ability and were more susceptible to copper-mediated low-density lipoprotein ( LDL ) -oxidation.
The MetS was defined dichotomously by current pediatric and adult criteria.
The mFI was developed using the Canadian Study of Health and Aging Frailty Index as a model.
The mHAI could provide incremental value for mortality risk prediction beyond clinically diagnosed chronic diseases among elders.
The MIAMOD method was applied also to estimate the colorectal cancer incidence , mortality and prevalence rates in the Ligurian provinces in the period 1988-2015.
The MIC90 for tigecycline was the highest in the group aged > 90 years.
The mice are also useful in defining the molecular pathways affected by the over-activation of GLUD in glutamatergic neurons of the brain and spinal cord.
The micelles were characterized by static and dynamic light scattering , electron microscopy , and asymmetrical flow field-flow fractionation.
The mice were assessed @number@ times per week for signs of arthritis and histologic features as well as serum immunoglobulin.
The mice were divided into @number@ groups @number@ saline infusion and saline injection ; @number@ saline infusion and sRAGE injection ; @number@
The microarray revealed that the majority of elastic fibre network components were unchanged with age.
The microbiology data were retrieved and selected from a literature search of the China Academic Journal Database between @number@ and @number@
The microbiota and its respective metabolites communicate to the host through a series of biochemical and functional links thereby affecting host homeostasis and health.
The microbiota regulates and acts as a key element in harmonizing immune responses at intestinal mucosal surfaces.
The microcirculation provides tissue perfusion , fluid homeostasis , and delivery of oxygen and other nutrients.
The microcirculatory changes were examined directly by fundus photography and fluorescein angiography and indirectly testing hearing and equilibrium.
The microglia showed a reduced expression of phagocytosis and / or endocytosis genes.
The microorganisms were isolated in @number@ cases : Staphylococcus aureus in @number@ cases ( including methicillin-resistant Staphylococcus aureus in nine ) and others in three.
The microRNA-31 ( miR-31 ) has been shown to be overexpressed in metastatic breast cancer.
The microRNA miR-17-92 cluster plays a fundamental role in heart development.
The microRNAs profile of ES CSCs is shared by ESCs and CSCs from divergent tumor types.
The microscopic worm Caenorhabditis elegans ( C. elegans ) is one of the most prominent animal models for aging studies.
The microspot size for the dot handpieces was ~ @number@.2-0.3 mm.
The microstate associated with these changes is a potential diagnostic tool to detect age-related cortical changes.
The microstructure of the samples was assessed through histology.
The microTBS results were affected significantly by the luting system used ( P < @number@ ) .
The microtensile bond strength of RelyX ARC and self-adhesive resin cements did not decrease after storage in artificial saliva and mechanical load cycling.
The microtensile bond strength ( μTBS ) was determined for each storage time.
The microtubule associated protein tau promotes neuronal survival through binding and stabilization of MTs.
The microvascular density was significantly decreased in the sunitinib-treated metastases compared with untreated tumors ( P = 0.001 ) .
The middle frequencies of hearing and cognitive functions may have a shared genetic basis.
The middle lamella was not touched during the procedure.
The middle portion of each vocal fold was removed and placed in @percent@ buffered formalin.
The midface has suffered vigorous challenges in terms of rejuvenation techniques over the years.
The midlife vaccine gap drastically impacts health in later life , especially in unvaccinated and older populations.
The mid-term follow up results showed favorable outcomes in patients receiving this surgery.
The mild cognitive impairment-AD group showed pronounced volume reductions in the posterior NbM , but preserved volumes of anterior-medial regions.
The milk group component of HEI-2005 had a significant negative linear relation with uNTx / Cr.
The Mill-Hill Vocabulary Scale was used to estimate premorbid cognitive ability.
The Mincer method showed very high mean variances.
The mineralization was measured by Alizarin Red S staining.
The minerals accumulated in scalp hair were measured by the inductively coupled plasma mass spectrometry method.
The Mini and 7D-PAR have the potential to accurately estimate TEE for older adults.
The Mini-Cog is a brief , cognitive screening test that is frequently used to evaluate cognition in older adults in various settings.
The minimal effective dose is @number@ IU per day.
The minimal number of the sebaceous glands was observed in children.
The Mini-Mental State Examination and the self-report of memory difficulties were also utilized.
The Mini Mental State Examination ( MMSE ) is the most broadly used cognitive screening instrument in clinical and research contexts.
The Mini-Mental State Examination ( MMSE ) test was performed to evaluate the cognitive status of patients and to exclude the diagnosis of dementia.
The Mini-Mental State Examination ( MMSE ) was adopted as an instrument to measure the cognitive function of adult who had self-reported memory decline.
The Mini-Mental State Examination ( MMSE ) was used to screen for dementia.
The Mini-Mental State Examination was used to assess cognitive function.
The minimum dose was one pill per day.
The minimum intake to achieve maximal retention is @number@ mg / day for white boys and @number@ mg / day for white girls.
The minimum mortality occur at BMI = @number@ Kg / m ( @number@ ) .
The minimum ΔE value was obtained for both blue light-filtering IOLs with middle-aged human lenses.
The Mini Nutritional Assessment ( MNA ) was used in evaluating each individual's nutrition.
The Mini-Nutritional Assessment short-form ( MNA-SF ) has been validated in international studies in a variety of settings.
The mini-nutritional assessment test was used as an assessment tool to detect nutritional risk.
The Mini Nutritional Assessment test was used to detect nutritional risk.
The MINIplus questions are not broad enough to assess other important self-destructive behaviors.
The mini-review stemmed from a recent meeting on national aging research strategies in China discusses the components and challenges of aging research in China.
The minor allele frequency for controls was derived from in-house genotyping data and publicly available databases.
The minor allele frequency ( MAF ) of rs662 was significantly higher in the longevity group than in the two control groups.
The minority of LAT partners who would not exchange care reciprocally are more likely to give as opposed to receive care.
The miR-15 / 107 family comprises a group of @number@ paralogous microRNAs ( miRNAs ) , sharing a @number@ AGCAGC sequence.
The miR-17 / 92 cluster is among the best-studied microRNA clusters.
The mismatch between explicit and implicit responsiveness to emotional cues was found both in behavioral variant FTD and in agrammatic variants of primary progressive aphasia.
The missense variants were unlikely to be disease causing , suggesting that VPS26A mutations are not a frequent cause of PD.
The Mississippi Delta is aging more quickly than the rest of the country , which explains @percent@ of the disparity in the time trend.
The mitochondria in the homogenate were more uncoupled compared with the Pfi.
The mitochondrial 12S rRNA is a hot spot for deafness-associated mutations in Chinese populations.
The mitochondrial alterations may be secondary to defects in nuclear DNA repair.
The mitochondrial common deletion ( CD ) mutation is induced by oxidative stress.
The mitochondrial DNA ( mtDNA ) 4977-bp deletion is a biomarker of mitochondrial genomic instability.
The mitochondrial DNA point mutation 11778G > A was identified in the ND4 gene.
The mitochondrial function deteriorates with aging , and the mitochondrial damage correlates with increased intracellular production of oxidants and pro-oxidants.
The mitochondrial genome encompasses hundreds of nuclear DNA ( nDNA ) -encoded genes plus @number@ mitochondrial DNA ( mtDNA ) -encoded genes.
The mitochondrial genome provides not only respiratory chain function , but it also ensures the impact of mitochondria on nearly all crucial metabolic processes.
The mitochondrial haplogroup may contribute some genetic risk for coronary heart disease.
The mitochondrial lysine deacetylase Sirtuin @number@ ( Sirt3 ) reverses this modification with benefits reported in diabetes , obesity , and aging.
The mitochondrial oxidative stress caused excessive apoptosis leading to low birth weight and growth retardation in the neonatal developmental phase in Tet-mev-1 mice.
The mitochondrial permeability transition pore ( MPTP ) has been implicated as a major factor associated with stroke-induced neuronal cell death.
The mitochondrial redox imbalance and mitochondrial DNA mutation might collaboratively involve in the process of cochlear senescence in response to the aging stress.
The mitochondrial sirtuin SIRT3 deacetylates numerous proteins in this organelle , regulating mitochondrial functions and suppressing diverse age-associated pathologies.
The mitochondrial structure and functionality were analyzed by confocal microscopy and electron microscopy.
The mitochondrial theory of ageing is one of the main contenders to explain the biochemical basis of the ageing process.
The mitochondrial theory of ageing proposes that accumulation of damage to mitochondrial function and DNA mutation lead to ageing of humans and animals.
The mitochondrial transcription factor A ( TFAM ) is required for mitochondrial DNA ( mtDNA ) replication and transcription.
The mitochondrial unfolded protein response is a conserved pathway that allows mitochondrial chaperones and other factors to be induced in response to mitochondrial dysfunction.
The mitochondrial voltage-dependent anion channel ( VDAC ) is a protein at the crossroads of metabolic and survival pathways.
The mitochondrion is the cellular organelle which consumes oxygen in order to synthesise ATP.
The mitochondrion represents an existentially defined endosymbiotic model of complex organelle development driven by evolutionary modification of a permanently enslaved primordial bacterium.
The mitofusin @number@ expression was reduced in cancer patients compared with controls , independent of CC.
The mitophagy regulators PTEN-induced putative kinase @number@ and Parkin were both down-regulated in cancer patients compared with controls.
The mitral isthmus line has many unwanted structures that may entrap the catheter , which is not the case for the LAA isthmus.
The mixed-effects model has been a useful tool for the analysis of such data.
The mixed-effects regression model was used for analysis of repeated measures of salt intake.
The mixed texture had more protein than the normal one and was better balanced regarding fat intake.
The mix of facility sizes varied by region.
The mixture modeling approach provides a powerful tool to identify latent groups with distinct cognitive trajectories.
The MLHFQ scores of the subjects improved significantly during the study period ( p < @number@ ) .
The MLRM presented a predictability of @percent@.
The MLS increased dependently with hematoma expansion with high correlation coefficients , yet no mortality occurred.
The MMN is a marker recorded through the electroencephalogram and is used to evaluate the integrity of the memory system.
The MM-related incidence and mortality have been increasing at an alarming rate over at least the past four decades.
The MMSE and the Braztel-MMSE were applied to @number@ AD patients and @number@ healthy elderly participants.
The MMSE is not sufficient to ascertain the negative effect of ECT on cognition.
The MNA and BI were positively correlated ( r = @number@ P = @number@ ) .
The MNA has become an extensively used tool to evaluate nutritional status in European countries and the United States.
The MNA questionnaire allows a valuable insight into the complexity of components of nutritional status and may provide useful clues for treatment strategies.
The mobility factors were found to have a stronger negative influence on HRQoL , i.e. , physical and mental , than functional ability in itself.
The MoCA should not be viewed as a substitute for more in-depth neuropsychological assessment when domain-specific information is required.
The MoCA test was administered to assess participants ' global neuropsychological profile.
The MoCA took an average of @number@.6min ; the time for the CCFM was @number@ min.
The model additionally includes significant positive indirect effects from spirituality , affective support and consciousness on satisfaction.
The model also emphasizes that quantitatively analyzing patterns of variability in ecological factors can shed light on diverse behaviors and patterns in nature.
The model also estimated weak but significant inverse genetic correlation for depression with cognition ( @number@ ) and memory ( @number@ ) .
The model also includes tips , tilts , and decentrations of the surfaces according to experimental findings.
The model-based clustering analysis revealed that social networks clustered into five types : diverse , family , congregant , congregant-restricted , and restricted.
The model-based individual's estimates could be used as an important tool to fit age-related patterns of the corresponding diseases and conditions.
The model borate glasses containing higher levels of TiO2 ( @number@ mol % ) tended to have longer working times and shorter setting times.
The model can be adapted to represent different therapeutic schemes and may offer useful indications for the optimization of therapy protocols in the transplanted patient.
The model controlled for socio-demographic factors and the use of cigars and SLT.
The model described in this viewpoint article is therefore likely to be an oversimplification.
The model did not support our hypotheses about modifying effects by age.
The model emphasizes care from the right skill level , for the right patient need , at the right time.
The model exhibited a @percent@ correlation between predicted and chronological age with a mean absolute deviation ( MAD ) from chronological age of @number@ years.
The model exhibited good discriminative accuracy , area-under-curve ( AUC ) of the receiver-operating characteristic of @number@ which was confirmed in a cross-validation approach.
The model explained @percent@ and @percent@ of variance in burnout and engagement.
The modelfree approach was applied to meta-analyze these studies.
The model had an area under the receiver operating curve of @number@ to concurrently predict a frailty phenotype.
The model had good fit ( comparative fit index = @number@ ) and explained @percent@ of the variance in knowledge and @percent@ in self-care.
The model has a good fit in terms of both the measurement and structural model.
The model has been explored in the context of Finland but still needs to be applied in other countries.
The model identified locations that consistently exhibited pulsatility across the sample.
The model included all ED and hospitalization episodes rather than just episodes linked to falls.
The model included delayed text memory , free recall , naming , orientation match , object decision , and alpha span.
The model includes a variable number of open walls and infinitely long cylinders as well as multiple geometric parameters.
The modeling showed that the loadings and intercepts of all measures are age invariant.
The model is based upon dimensionless parameters , an important criterion for inter-species comparisons where lens sizes can vary greatly ( e.g. bovine ( approx.
The model is person-centered and allows team members to practice to the full extent of their education and training.
The model is polychromatic , and its optical performance was evaluated along the keratometric axis.
The model is used for developing new statistical methods for analyzing longitudinal data on aging , health , and longevity.
The model of successful aging generated from this study appears to be more comprehensive than existing models and incorporates sociocultural experiences.
The model organism Caenorhabditis elegans offers a promising solution for studying the potential bioactivity and molecular mechanisms of natural compounds in vivo.
The model parameters have been estimated by regression from the observed CML incidence curves.
The model performed fair in external validation ( c statistic = 0.69 ; @percent@ confidence interval , @number@ to @number@ ) .
The model predicted a nonlinear response and damage region.
The model predicted female occipital and temporal lobes to be @number@ kPa and @number@ kPa stiffer than males of the same age , respectively.
The model predicting desire for palliative care was not significant.
The model predicts , therefore , that interventions designed to unjam the endosome carry high therapeutic promise.
The model provides a predication on medical service demand of these three types of disease up to @number@
The model qualitatively captures the experimental observations and accurately describes the effect of iron , NAC , and DMSO on the apical distribution of DMT1.
The model reconciles procedural and representational accounts of the specificity-of-learning phenomenon.
The model reflects the provisions of thermodynamics , gerontology and typical results observed in medical experiments.
The model revealed the importance of music to support the personal psychology of people with dementia and the social psychology of the care home environment.
The models differed across diagnostic groups.
The model sheds new light on available evidence and current debates and fosters the search for mechanistic explanations.
The model showed that health literacy , knowledge , communication capacity , and diabetes self-care formed complex relations.
The model showed that the discounted total lifetime cost of Medicare benefits was $ 174 , 018 per person , from age @number@ until death.
The model shows significant improvement in prediction accuracy over several age-based body weight prediction methods.
The model shows that there are substantial opportunities for savings through modest improvements to the health of the Medicare population.
The model shows that the variability is partly due to stochastic effects but also depends on protein expression levels of UCH-L1 within cells.
The models included number of HZ cases parsed into categories by chronological-age and time-since-vaccination as the dependent variable with different explanatory variables in each model.
The models remained robust after adjusting by baseline cognition except for dual-task gait cost when dichotomized.
The model stresses the role of time , both as individual aging and as the anchoring of lives in particular historical periods.
The models were adjusted for age , systemic E2 , and total body fat mass.
The models were used to highlight areas of bone growth and bone resorption using a color scale and to perform a cephalometric analysis.
The models yielding the highest AUC were retained as optimal.
The model takes in four parameters , including age-based CDC-inferred median body weight and three facial feature distances measured from digital facial images.
The model that combines the four parameters measured on the vertebral bodies , the age and the gender showed an excellent prediction.
The model was adjusted stepwise for sex , age , education , functional capacity , and depressive mood.
The model was also analyzed stratifying for BMI tertiles.
The model was examined with three simulated data sets and one experimental data set.
The model was matched with the staff requirements for each department.
The model was then compared by gender.
The model was then compared by gender.
The model worked best at predicting cognitive level when cutoff scores were used to classify individuals into impaired vs. not nonimpaired.
The mode of action for Naclynamide™ as a first-in-class anti-cancer drug candidate is discussed.
The mode of action , however , remained elusive.
The mode of action of these small molecules has not as yet been fully elucidated at the molecular level.
The mode of vaginal delivery had no significant effect on continence scores or manometry pressures.
The moderate changes in the talar neck might explain the persistent low incidence of talar neck fractures with age.
The moderate knowledge level among both genders uncovered in this study is of concern.
The moderating effects of cardiometabolic conditions , physical functional limitations and WM hyperintensities were also examined , as they can affect PA and brain integrity.
The modern pharmacological research shows that Eucommia ulmoides has many functions , such as anti-aging , antitumor and bone cell proliferation.
The modest data available suggest similar benefits in older patients and excellent safety.
The modifiable features of meaning in life may offer an intervening angle for improving the well-being of elderly stroke survivors.
The modifiable risk factors for subclinical cerebrovascular disease beyond hypertension have not been well characterized.
The modifiable risk factors identified provide direction for prevention efforts to increase SA at a population level.
The Modified Barthel Index was used to measure functional status on admission and discharge.
The Modified Caregiver Strain Index was selected for the assessment of caregiver burden , while GAS was selected for participation level outcomes.
The modified Clinical Test of Sensory Integration for Balance and the Tandem test have been used to screen for balance.
The modified DNA was highly immunogenic eliciting high titre immunogen specific antibodies , while the unmodified form was almost non-immunogenic.
The modified frailty index may be a useful tool in predicting mortality , guiding patient and family expectations and elucidating implant / surgery choices.
The modified Jadad scale assessed the quality of the methodology of the published papers.
The modified Kaplan-Meier method was used to calculate the lifetime risk of CVD.
The modified lipoprotein properties with impaired antioxidant functions can be used as a putative biomarker for prognostic detection for the relatively young onset AF.
The Modified Mini-Mental State Examination assessed cognitive function.
The modified PF model could capture and categorize the future risk of MOF more accurately than the original model.
The modular approach taken allows model parameters to hold inherent and intuitive meaning , offering advantages over more generalized methods such as principal component analysis.
The modular organization of structural brain networks was similar between the young and middle age groups , but quite different from the old group.
The modulation of biological processes associated with skin aging was measured by Reverse Transcription quantitative PCR ( RT-qPCR ) .
The modulation of microglial proliferation , activation and secretion by baicalin could be a promising therapeutic option for the treatment of Alzheimer's disease.
The modulation of parasympathetic tone in daily activities plays an important role in the longevity of very elderly residents of long-term care facilities.
The modulatory connections associated with relational integration increased with age.
The molecular basis for this duality of action remains unknown.
The molecular basis of selective neuronal vulnerability in Alzheimer's disease ( AD ) remains poorly understood.
The molecular basis of the association of 14-3-3ζ within NFTs and the pathological significance of its association are not known.
The molecular basis of these activities remains poorly understood , although increasing evidence suggests that a variety of mechanisms may be involved.
The molecular changes in PPEDA films were studied over a long-time period of @number@ days.
The molecular clock comprises two transcription factors , CLOCK and BMAL1 , whereas PERs and CRYs are responsible for the negative limb.
The molecular composition and concentration of lipid species determine their cellular localization , metabolism , and consequently , their impact in disease and health.
The molecular determinants of muscle progenitor impairment to regenerate aged muscles are currently unclear.
The molecular function and regulatory mechanism of circRNA 100269 in GC cell lines were also elucidated.
The molecular HPV research was negative , while the Thin prep pap-test was indicative of vaginosis and cellular reactive changes associated with inflammation.
The molecular mechanism behind these events involves p16-mediated signaling pathway ( or p16- Rb pathway ) , the focus of our study.
The molecular mechanism of action of As-MIF and human JAB1 are poorly understood.
The molecular mechanism of this process is , however , only poorly understood.
The molecular mechanisms behind this senescence remain largely obscure , precluding targeted approaches to counteract aging.
The molecular mechanisms involved in epithelial ovarian cancer initiation and progression are just beginning to be elucidated.
The molecular mechanisms involved in human immunodeficiency virus ( HIV ) -associated neurocognitive disorder ( HAND ) remain poorly understood.
The molecular mechanisms involved in prostate cancer are diverse and heterogeneous.
The molecular mechanisms leading to and responsible for age-related , sporadic Alzheimer's disease ( AD ) remain largely unknown.
The molecular mechanisms leading to fibroblast dysfunction during aging and the senescent process have not yet been clarified.
The molecular mechanisms of signal transduction are complex and are specific of the tissues where GHS-R1a is expressed.
The molecular mechanisms underlying AHL are unknown , and currently there is no treatment for the disorder.
The molecular mechanisms underlying BP regulation , however , remain unclear.
The molecular mechanisms underlying lin- BMC senescence and apoptosis are poorly understood.
The molecular mechanisms underlying rod photoreceptor vulnerability and potential biomarkers of the aging process in this highly specialized cell type are unknown.
The molecular mechanisms underlying the carcinogenic effects of arsenic species remain incompletely understood.
The molecular mechanism through which ELF-EMFs can influence cellular behavior is still unclear.
The molecular pathophysiology of heart failure , which is one of the leading causes of mortality , is not yet fully understood.
The molecular pathways involved in triggering and / or maintaining the senescent phenotype are not fully understood.
The molecular signaling of resveratrol and cellular mechanisms that make this botanical active an important anti-aging ingredient for topical application will be discussed.
The molecular subtype of sporadic Creutzfeldt-Jakob disease ( sCJD ) is an important prognostic marker for patient survival.
The molecules that carry out these roles are complex , utilizing non-amino acid cofactors and earth-abundant metals.
The money cannot be used prior to retirement.
The monitoring of cancer survival by population-based cancer registries is a prerequisite to evaluate the current quality of cancer care.
The MoNNET-HA cohort consists of men and women aged @number@ years and older , residing in the Montreal Metropolitan Area ( MMA ) .
The monochromatic wave aberrations were described using a sixth-order Zernike polynomial expansion.
The monotonic relationship between educational attainment and longevity was observed for all age groups , except for those aged @number@ years or more.
The monotonic trend was sustained across different strata of age , gender , and disease complexity.
The Monte Carlo simulations project that females will be a bigger driver of GMS costs than males.
The Montgomery-Asberg Depression Rating Scale was administered to measure depression severity.
The Montreal Cognitive Assessment ( MoCA ) can address this need , but has limitations in a survey context.
The Montreal Cognitive Assessment ( MoCA ) screen was developed as a brief instrument to identify mild cognitive impairment and dementia among older individuals.
The mood state profile was analysed using a visual analogue scale and the state-trait anxiety inventory.
The morbidities most cited by the elderly who participated in educational activities were : hypertension and vision problems.
The morbidity data recorded in family practice ( FP ) were extracted from Croatian Health Service Yearbooks for the years 1995-2012.
The morbidity of hyperglycemic crises and acute hypoglycemic attacks in patients with diabetes mellitus has been increasing for the past several decades.
The more \ "active \ " the cat , the fewer non-overlapping patterns occurred per minute , but the higher was the event type complexity.
The more factors on which positive tendencies were reported , the greater the likelihood of having good health.
The more frequent diseases treated were colorectal surgery @percent@ , followed by hepatobilopancreatic surgery @percent@ , upper gastro-intestinal @percent@ , and others @percent@.
The more frequent dosing needed for NOACs may reduce adherence , especially in elderly patients with polypharmacy.
The more important is that the storage symptoms contribute significantly more effects on QOL than the voiding symptoms ( P = 0.0032 ) .
The more promising strategies involved pharmacists or multidisciplinary teams including geriatric medicine services.
The more rare bacteria require culture on special media to provide an early diagnosis to enable proper antimicrobial therapy to commence.
The more recent guidelines for treating osteoporosis now include men , but the recommendations for screening and treatment are not necessarily gender specific.
The more recently introduced oscillometric device is simpler to use.
The more severe is the fact that older pedestrians are among the most vulnerable road users.
The more time since spousal driving cessation , the less likely husbands were to work and the less likely wives were to formally volunteer.
The morphological and biochemical changes in the aging brain are the subjects of many extended research projects worldwide for a long time.
The morphological and biomechanical properties were similar to those of a native enthesis.
The morphological and functional features of incomplete regeneration and reinnervation are compared between adult and aged animals.
The morphological changes and nucleocytoplasmic ratio of MSC were observed using Giemsa staining.
The morphological characteristics of aged synapses could shed light on the underlying molecular changes and their functional consequences.
The morphological features of the EM were observed and recorded in each patient during decompression.
The morphological properties of orbital adipocytes were assessed and the fat cell size displayed a decreasing trend with advancing age.
The morphologic changes in the tissue composition and structure also infer the structural and functional difference between aged human valves and those of animals.
The morphology and physiology of both the vulva and vagina undergo characteristic age-related changes over a lifetime.
The morphology and size of the ANHCPS were well tailored by tuning reaction conditions such as monomer molar ratio , temperature , and copolymerization time.
The morphology of cultured normal human epidermal keratinocytes ( NHEKs ) transfected with a miR-124 mimic changed to an enlarged and irregular shape.
The morphology of the cervical spine was assessed by lateral cephalometric radiographs obtained in accordance with an innovative method for establishing a standardized head posture.
The mortality among patients with heart diseases increases steadily in an aging society like Japan.
The mortality at @number@ years was lower in the elderly than in the younger patients ( @number@ vs. @percent@ ; P < 0.001 ) .
The mortality in frail patients is further driven by FTR from postoperative complications.
The mortality of the patients with both shock and PI was very high ( @percent@ ) .
The mortality of the subpopulations aged 1-54 years tended to be lower than the national averages.
The mortality prediction of SHARE-FI75 + was similar to that of the other SHARE frailty scales.
The mortality rate for prostate cancer remains stable , with a slight decline in recent years.
The mortality rate for upper cervical spine injury was similar in all groups.
The mortality rate of participants living in residences is three times greater than those of participants living in the community.
The mortality rate over the study period was @number@ per @number@ person-years , this solely among persons born overseas.
The mortality rate reaches almost nine times higher among men comparably to women , being higher in North and Northeast regions.
The mortality rate was found to be @percent@.
The mortality rate was @percent@ after @number@ mo.
The mortality rate was @percent@ in the first phase and @percent@ in the second phase.
The mortality was @percent@ in the control group and @percent@ , @percent@ , and @percent@ , respectively , during the next three consecutive 9-month intervals.
The mosquitoes were counted , identified using morphological and molecular markers and dissected to determine parity.
The mosquito species Aedes albopictus is a major vector of the human diseases dengue and chikungunya.
The most active group , however , had a more benign composition of plaques , with fewer mixed plaques and more often only calcified plaques.
The most advanced finding at colonoscopy was CRC , advanced adenoma , and nonadvanced adenoma in @number@ @number@ and @number@ cases , respectively.
The most affected organs included the lungs , oropharyngeal mucosa , lymph nodes , skin , and larynx.
The most appropriate treatment approaches and their benefits are still unknown.
The most broadly and well-studied pathways influencing ageing are the insulin / insulin-like growth factor @number@ signaling pathway and the dietary restriction pathway.
The most challenging arose because of how critical gonadal hormones are to brain function , especially as determinants of brain sexual differentiation.
The most cited barriers were quality improvement tracking and implementation.
The most common action of the platysma was drawing the lips inferiorly ( @percent@ ) or posteriorly ( @percent@ ) .
The most common adverse events were gastrointestinal.
The most common adverse reactions to HEMA / EMA in HA and PLA were nodules and hardening.
The most common afatinib-related adverse events were rash / acne ( @percent@ ) and diarrhea ( @percent@ ) .
The most common and concerning adverse event is postinflammatory hyperpigmentation.
The most common biomechanical postural control task outcomes were spatial measures , temporal measures , and end-points of lower extremity joint kinetics.
The most common cardiovascular involvement type is pericarditis.
The most common causative bacterium , Streptococcus pneumoniae , frequently colonises the upper respiratory tract , where it resides mostly asymptomatically.
The most common cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of the inner ear.
The most common causes of adenoviral keratoconjunctivitis in Saudi Arabia were adenovirus types @number@ @number@ and @number@
The most common change was an increase in the expression of lipid metabolism genes.
The most common chronic disease of participants was hypertension ( @percent@ ) .
The most common combination of multiple diseases was hypertension with dyslipidemia ( @percent@ ) or diabetes ( @percent@ ) .
The most common complex syndromes were qi deficiency complicated qi stagnation syndrome and qi deficiency complicated blood deficiency syndrome.
The most common complications involved infection , mainly sepsis and surgical site infections.
The most common complications , stroke and heart failure , result in significant morbidity and mortality.
The most common complications were acute cardiovascular events ( @percent@ ) , electrolyte disturbances ( @percent@ ) , and hypoxemia ( @percent@ ) .
The most common complication was inflammation ; other complications were hardening , migration , and accumulation of the product.
The most common conditions-age-related and noise-induced sensorineural hearing loss-are both progressive and , for the foreseeable future , neither curable nor reversible.
The most common dermatoses were Eczema in females followed by Photodermatitis and comparatively in males viral and fungal infections were common.
The most common destinations were within the neighborhood : parks and streets for recreation walking and shops and eating places for transport-related walking.
The most common drug-disease interaction was aspirin / NSAID use in those with history of peptic ulcer disease without gastroprotection.
The most common eating pattern in modern societies , three meals plus snacks every day , is abnormal from an evolutionary perspective.
The most common European haplogroup is H while individuals of maternal African origin are of the L haplogroup.
The most common finding associated with anti-Ro antibodies is prolonged corrected QT ( QTc ) interval.
The most common finding during gynecological examination was cystocele @percent@ , followed by rectoenterocele @percent@ , and central defect @percent@.
The most common form of BEEC is isolated classic bladder exstrophy ( CBE ) .
The most common form of sensory disability is age-related hearing loss ( ARHL ) , also referred to as presbycusis.
The most common forms of back pain are mechanical.
The most common genomic changes that interface with the environment and cause complex disease must , therefore , be mitochondrial and epigenomic in origin.
The most common health complications in survivors were hearing impairment , second cancers , diabetes , hypertension , and endocrine deficiencies.
The most common HGPS mutation is found at position G608G within exon @number@ of the LMNA gene.
The most common ICD was intermittent explosive disorder ( @percent@ ) , followed by pathological gambling ( @percent@ ) .
The most common level affected by myelopathy was C5-C6.
The most commonly assessed outcome was mental health , which included depressive symptoms , stress or distress , and anxiety.
The most commonly noted adverse reaction was transient erythema ( @percent@ ) lasting from a few hours to a day.
The most commonly reported impacts were within the dimensions ' physical pain ' and ' psychological discomfort'.
The most commonly seen adverse events were hematological toxicity , nausea , vomiting , fatigue , alopecia , joint and muscle pain.
The most commonly used AEDs were carbamazepine , gabapentin , pregabalin , valproic acid and lamotrigine.
The most commonly used analgesic was acetaminophen ( @percent@ ) .
The most commonly used are oxybutinin , tolterodine , solifenacin , darifenacin , fesosterodine and trospium.
The most commonly used current AEDs were phenytoin , gabapentin , levetiracetam , and lamotrigine.
The most commonly used regimen is the classical CHOP21 ( cyclophosphamide , doxorubicin , vincristine and prednisone ) regimen.
The most commonly utilized non-prescription drugs were analgesics and antipyretics , followed by non-hormonal anti-inflammatories , cardiovascular agents , dietary complements and alternative medicine components.
The most common mechanism of injury was falls ( @percent@ ) , and most patients were men ( @percent@ ) .
The most common medications taken were for gastrointestinal , neurological , and cardiovascular disorders.
The most common misconceptions on the ADAPS indicated a tendency for participants to overgeneralise the cognitive effects of normal ageing.
The most common pathogenetic factors for male erectile dysfunction are vascular diseases.
The most common perceived environmental barrier to engaging in physical activity was the fear of falling , particularly on the ice during the winter months.
The most common PIMs were muscle relaxants and urinary antispasmodics.
The most common presentation shown by chest computed tomography ( CT ) was pneumonic opacity ( eight cases , @percent@ ) .
The most common preventive medicine discontinued was statins , followed by warfarin and aspirin.
The most common primary osteoporosis occurs as a result of menopause and aging process.
The most common product of carbamylation is homocitrulline ( HCit ) , where a lysine ( Lys ) amino group has reacted with urea-derived cyanate.
The most common reasons for presentation were agitation , intrusiveness , and paranoia.
The most common reasons for use of supplements in children are for health promotion , yet little scientific data support this notion in nutrient-replete children.
The most common reasons given for decreases were as a health precaution and fewer social occasions.
The most common results of polypharmacy are increased adverse drug reactions , drug-drug interactions.
The most common risk factors associated with POP were : multiparity with vaginal deliveries , obesity and aging.
The most common site of LDH is toward the bottom of the spine at L4-L5 and / or L5-S1.
The most common symptoms were impaired balance and / or falls ( @percent@ ) and morning drowsiness ( @percent@ ) .
The most common tau-negative type is FTLD with ubiquitinated inclusions , which are composed of TAR DNA-binding protein-43 ( TDP-43 ) ( FTLD-TDP ) .
The most common TDP-43 proteinopathies , frontotemporal lobar degeneration with TDP-43-positive inclusions , and amyotrophic lateral sclerosis , share overlapping neuropathological and clinical phenotypes.
The most common turning points identified were relationship and occupation related.
The most consistent and well-reported changes are luminal enlargement with wall thickening and a reduction of elastic properties at the level of large elastic arteries.
The most consistent disagreements involved global ratings of depression where caregiver scores ranged from @number@ higher to @number@ lower than clinician rating.
The most consistent predictor of UPDRS part III was baseline level of activities of daily living ( part II ) .
The most cost-effective proposal , would lead to a saving of < euro > @number@ , 950 / year in the studied sample.
The most critical factor for aging-related BDR is FSH in women while a decreased level of estrogen may be secondary.
The most damaged spinal segment was determined in each patient from the preoperative neurological and image findings along with the remaining symptoms at follow-up.
The most demanding criterion was high function , closely followed by absence of disease , while approximately two-thirds were actively engaged in life.
The most demonstrative indications favoring this conclusion originate from recent discoveries of the in vivo effects of mitochondria-targeted antioxidants ( MitoQ and SkQs ) .
The most disastrous complication was alar rim necrosis following injection of the nasolabial fold.
The most distal epiploic branch that feeds the bypass is approximately @number@ mm ( range : 161-195 mm ) of the origin of the GEA.
The most distal SNP was located up to @number@ kbp from the IGF-1 gene.
The most distinctive interaction effect of age and gender was found in ME out of the four FCC measures.
The most effective approaches may be those tailored to the individual.
The most effective means available for reducing the burden of stroke involves risk factor modification.
The most effective measure of prevention of the photoaging and photocarcinogenesis is sun protection.
The most effective PDE-Is in preclinical models of aging and AD appear to be PDE2-Is , PDE4-Is and PDE5-Is.
The most efficient elution range for high-resolution phosphopeptide separation was between pHs @number@ and @number@
The most evident reduction occurs in the antral follicles of 5-7 and 8-10 mm with the highest number of AMH secreting granulosa cells.
The most frequent aberrancy is the \ "common deletion \ " that involves a @number@ , 977-bp region flanked by 13-bp repeats.
The most frequent adverse event ( excessive perioral weakness ) was related to high dose in the perioral area.
The most frequent barriers were internal ( e.g. , age / health restrictions ) .
The most frequent cancer locations were breast ( @percent@ ) , colon-rectum ( @percent@ ) and lung ( @percent@ ) .
The most frequent cause of SIADH is the use of drugs that induce secretion of the hormone.
The most frequent changes were drug discontinuation ( @percent@ ) and dose reduction ( @percent@ ) .
The most frequent clinical complication with zirconia-based FDPs was chipping of the veneering porcelain that was affected by many factors.
The most frequent complication was chipping , which was directly related to the number of units of the prosthesis.
The most frequent diagnoses include colorectal cancer , lung cancer , breast cancer , and prostate cancer.
The most frequent DIs were reported in five articles.
The most frequent failure mode exhibited was mixed failure involving the enamel-resin-bracket interfaces.
The most frequent genotype identified was HPV58 ( @percent@ of typified samples ) .
The most frequent inappropriately prescribed drugs were calcium antagonists ( overprescribed ) , ACEIs and beta-blockers ( underprescribed ) .
The most frequent interventions in the included studies were physical exercise ( @number@ ) and nutritional supplementation ( @number@ ) .
The most frequent late complications were lymphovascular ( N = 25 / 61 , @percent@ ) .
The most frequently cited reason given by those who did not favour routine screening at age @number@ was screening inaccuracy.
The most frequently colonizing serotypes were : 19F , 23F , @number@ 19A , 6B and @number@
The most frequently implicated drugs are corticosteroids , even after local or inhaled treatment.
The most frequently involved area is the ileocecal region.
The most frequently mentioned were sudden weakness , dizziness , and headache.
The most frequently occurring adverse events were nausea and constipation.
The most frequently p53 mutated codons of lung cancer are @number@ ( exon @number@ ) and @number@ ( exon @number@ ) .
The most frequently performed activities were walking and wheeling.
The most frequently registered diagnostic groups were cardiovascular and neoplasms , followed by the groups of endocrine , urogenital and musculoskeletal diseases.
The most frequently reported adverse events ( AEs ) were drowsiness ( @percent@ ) and dry mouth ( @percent@ ) .
The most frequently reported CHC was high cholesterol ( @percent@ ) followed by hypertension ( @percent@ ) and diabetes ( @percent@ ) .
The most frequently reported illnesses ( as diagnosed by a physician ) were musculoskeletal disorders , endocrine / metabolic diseases , and cardiovascular diseases.
The most frequently reported phantom smell was smoky / burnt.
The most frequently reported reason for not having one was lack of awareness.
The most frequently reported skin feature was sclerodermoid change , which commonly involved the abdomen and bilateral lower extremities.
The most frequently used methods index explicit emotion recognition and / or mental state attribution.
The most frequently used model to describe the exponential increase in mortality rate over age is the Gompertz equation.
The most frequently used potentially inappropriate anticholinergics were cyclobenzaprine , promethazine , amitriptyline , hydroxyzine and dicyclomine.
The most frequent organism causing IE was Streptococcus viridians both in the 1990s and 2000s.
The most frequent prescribers were psychiatrists and general practitioners.
The most frequent reasons for revision surgery of the same motor segment were recurrent disc herniation , inadequate decompression and inappropriate surgical technique.
The most frequent sites of fragility fractures are the hip , the distal radius , the spine , the proximal humerus , and the ankle.
The most frequent sites of injury were the lower extremity , thorax , upper extremity , and head.
The most frequent site was hip ( IR = @number@ per @number@ person-years ) and the IR of vertebral fractures was @number@ per @number@ person-years.
The most frequent transition pattern was transition to the hospital and back.
The most frequent tumor locations were the lower extremity ( N = @number@ @percent@ ) and the trunk ( N = @number@ @percent@ ) .
The most frequent vascular pathologies in the aging brain and in AD are cerebral amyloid angiopathy and small vessel disease.
The most important affected pathway is PI3K-Akt signaling.
The most important affected pathway is PI3K-Akt signalling.
The most important and consistent predictors of access in all cases were those that measured health care need.
The most important aspect of polyclinic services related to menopause is to increase and maintain women's quality of life.
The most important constraints on participation in leisure were lack of accessibility , material considerations , functional abilities , affective constraints and social constraints.
The most important effect of hypotension is cerebral hypoperfusion , which can induce syncope and fall.
The most important effects result from DNA damage , due to the mutations formation , which can lead to the development of tumors.
The most important function of Hippocampus in TCM is invigorating kidney-yang.
The most important molecular mechanism for malnutrition associated with chronic obstructive pulmonary disease appears to be the mismatching between protein synthesis and breakdown.
The most important new aspect in andrology is the publication of the World Health Organization laboratory manual for semen analysis in @number@
The most important predicting pattern for mortality was the combination of AF , CKD , and visual impairment after @number@ years.
The most important predictor was admittance from nursing home , which was associated with comorbidity and frailty.
The most important result is that there are multiple studies reporting positive lifestyle changes in an older population.
The most important results related to morphological , histological and molecular biological changes are summarized.
The most important risks of this treatment are scarring and dyspigmentation.
The most informative features for the patient versus control task were low frequency content words , generic terms and components of metanarrative statements.
The most intensive service that includes identification , assessment and treatment of patients appears to deliver the best outcomes.
The most interesting aspects of PDT is the absence of severe delayed adverse events and an optimal healing.
The most interesting result in this work is that mechanism underlying lithium action was not related to the inhibition of GSK3 activity.
The most investigated source of MSCs is bone marrow ( BM ) .
The most notable finding to emerge from this study is that neuroticism is not associated with marital satisfaction , neither husbands nor wives.
The most notable mutation is the lamin A mutation Q432X that alters LINC complex protein assemblies and causes chromosomal and transcription factor rearrangements.
The most obvious change was improvement in the lateral part of the nasolabial folds.
The most obvious reason for nocturia in patients with OAB was the polyuria and reduced nocturnal bladder capacity , which are not dependent on age.
The most of the examinees that use DSWL were overweight and used it for esthetic reasons.
The most physiologically relevant loading direction of tendon is along its longitudinal axis.
The most physiological type of cell cycle arrest - namely , contact inhibition in dense culture - is the least densely studied.
The most popular are the non invasive methods to decrease the signs of aging.
The most popular investigation area for the scientists has been the oxidant and anti-oxidant systems in different tissues.
The most popular primary caregiver was the patient's spouse and @number@ % patients mentioned that they were having problems managing the finances.
The most powerful component is strength-and-balance exercise training.
The most powerful predictors for outcomes are the severity of heart failure , the presence of comorbidities , and prolonged hospitalization at baseline.
The most predictable variables of DNA SBs were the aerobic capacity and MDA.
The most predominant pattern in the entire study population was Type I ( @percent@ ) .
The most prevalent CVD risk factor was hypertension ( @percent@ ) and the lowest one was smoking ( @percent@ ) .
The most prevalent hypothesis concerning the relationship between reproduction and longevity predicts that reproduction is costly , particularly in females.
The most prevalent physical activity was walking for adults aged ≥ @number@ years old ( 41-52% ) regardless of SCD status or receipt of care.
The most prevalent risk factor of idiopathic ERM was aging.
The most prevalent stroke type was ischemic.
The most prevalent symptoms were physical in nature.
The most prominent changes seem to occur in the outer retinal layers of the central fovea.
The most prominent characteristics of mitochondrial aging are their structural alterations and mitochondrial DNA damage.
The most prominent effects of aging include visual impairments , particularly age-related cataracts ( ARC ) .
The most prominent mitochondrial mutation is the common deletion ( CD ) , which is induced in many tissues by oxidative stress.
The most promising in terms of pregnancy were the I and II groups.
The most promising of these compounds is called probucol.
The most promising rs3741916 variant is unlikely to be functional given opposing effects in different series.
The most prone to DKA were children under @number@ yr of age ( n = @number@ ) .
The most pronounced changes may be found in the executive functions that require integrity of the prefrontal cortical circuitry.
The most proper cutoff point of MNA-SF was lower than @number@
The most rapid loss of bone density occurs after actual menopause.
The most recently discovered @number@@number@'-cyclic nucleotide phosphodiesterase family is the Phosphodiesterase @number@ ( PDE11 ) family , which is encoded by a single gene PDE11A.
The most recent review used search strategies conducted over a decade ago and concluded that study findings were equivocal.
The most relevant features are hair abnormalities , physical and mental retardation , ichthyosis , signs of premature aging and cutaneous photosensitivity.
The most relevant ones were chosen as references for the current review article.
The most representative similarity degrees were between @percent@ and @percent@ considering @number@ frailty factors from @number@ patient instances.
The most robust differences in MD were between the 50-59 and 70 + age groups.
The most salient deficit appearing from the early stages of dementia / Alzheimer's disease ( AD ) is a deterioration in memory.
The most salient needs were \ "love and care \ " for spouse and \ "contact and often meeting \ " for children and friends.
The most serious were as follows : one patient ( < 0.5% ) died ; and four ( < 2% ) patients underwent reoperation.
The most severe disorder being premenstrual dysphoric disorder ( PMDD ) affects 3-8% of women of reproductive age.
The most severe grade occurred primarily in elderly patients.
The most severe signs of CVD ( edema , venous ulcers ) show a significant progression in the aging segment of the population.
The most significant association between age and adipose tissue DNA methylation was found upstream of ELOVL2.
The most significant change was an age-related decline in RbAp48 , a histone-binding protein that modifies histone acetylation.
The most significant complications include vascular damage , stroke , paravalvular aortic insufficiency , and heart block.
The most significant differences were achieved between the youngest and the oldest participants ' groups.
The most significant differences were noted in the upper lip area , where the thickness had increased by an average of @number@ mm.
The most significant drop in MWSS occurred between the age groups 48-57 and 58-67 ( P < @number@ for @number@ vessels ) .
The most significant factor contributing to the overall change in the appearance of an individual's facial features over time is age.
The most significant of them are osteoporosis , osteoarthritis and sarcopenia.
The most significant patient concerns were formulary and copayment ( @number@ % ) and Donut hole ( @number@ % ) .
The most significant single-nucleotide polymorphism was rs7911500 ( P = 1.31×10 ( @number@ ) ) .
The most similar associations happened between weakness and slowness ; weakness , slowness , and LPAL ; or weakness , slowness , and exhaustion.
The most substantial change is that the cognitive disorder-not otherwise specified category found in prior editions has been eliminated.
The most substantial increases were observed in individuals with the lowest baseline scores.
The most suitable method is the consumption of natural antioxidants in the form of fruit and vegetables , for example.
The most useful laboratory tests for its diagnosis are urinary sodium concentration , plasma osmolality and urinary osmolality.
The most vulnerable areas are those that are supplied by a single arterial branch ; for example , the glabellar and nasolabial folds are susceptible.
The most widely-endorsed criteria for adulthood were accepting responsibility for one's self , making independent decisions , and becoming financially independent.
The most widely used neuronal markers comprise phosphorylated and nonphosphorylated neurofilaments , microtubule-associated protein-2 , NeuN , or synaptic markers such as synaptophysin.
The motivational Simon task-a new paradigm in which rewards and punishments are delivered to promote fast and accurate responses-was employed.
The motivation for identifying the genetics of LOAD is clear.
The motivation is mainly on the role of information asymmetries between elder consumers and financial institutions.
The motivation to perform therapy as well as the physical ability to do so also changes with age.
The motor response is usually the main dependent variable in studies regarding physical or cognitive decline in aging.
The motor test battery included measures of strength ( force-generating capacity ) , gait speed , and static and dynamic balance.
The mouse clinical frailty index and the mouse frailty phenotype assessment are two recently developed tools used to assess frailty in mice.
The mouse clinical frailty index identified @number@ mice as frail and the agreement between the two scales was @percent@.
The mouse frailty phenotype assessment identified no mice as frail but modification of the assessment tool identified six mice as frail.
The mouse has proved an essential tool in the identification of early-onset deafness genes and in revealing the basic mechanisms of hearing.
The mouth regions in the bilateral primary sensorimotor areas were activated more significantly during the repetition task relative to the perceptual task.
The move away from family influence towards independence and self-determination is filled with uncertainty.
The move away from publicly funded and publicly administered long-term care is accelerating under the leadership of Premier Ed Stelmach.
The movement of the hyoid bone during swallowing can be visualized by US.
The movement patterns were classified as hip , ankle or mixed strategies based upon joint kinematics.
The moving average showed a decrease of MDA levels in the endometriosis group with increasing female age.
The MPC represents a central node of carbon metabolism , and its activity is likely to play a key role in bioenergetics.
The MPN-restricted driver mutations , including those in In glaucoma , lowered intraocular pressure ( IOP ) confers neuroprotection.
The MPOD distribution was unrelated to the slope of the foveal pit or the choroidal thickness.
The MPOD values were not associated with sex , BMI or smoking status.
The MPOD was assessed using 2-wavelength autofluorescence ( AF ) .
The MRI scans showed a decrease in thickness and redistribution towards a length increase but no total volume loss.
The mRNA and protein expression of predicted targets was not significantly affected by the intervention.
The mRNA and protein expression of TRP channels in HGPS and control ( IMR90 ) iPSC-ECs were examined by semi-quantitative RT-PCRs and immunoblots , respectively.
The mRNA and the protein of AdipoRs in the retina were detected with qRT-PCR and western blotting , respectively.
The mRNA expression of GDF11 in mesenchymal cells from the COPD group was decreased.
The mRNA expression of IL-17 , IL-17F , IL-22 , and RORC2 was also significantly increased in aged people.
The mRNA levels of antioxidant enzymes and pro-inflammatory cytokines were detected using quantitative real-time polymerase chain reaction.
The mRNA levels of SOD1 , SOD2 and CAT were quantified by qPCR.
The MSNA was greater in the older groups ( P < @number@ ) only ( sex , P = @number@ ) .
The MSP Master file contains claims reported for every provincially insured medical service and supplementary health benefit including chiropractic visits.
The mTBS was analyzed using one-way ANOVA ( SPSS @number@ ) .
The mtDNA content was found to be inversely associated with age among the age of group 40-70 years.
The mtDNA control region regulates gene expression and replication of the genome of this organelle.
The MTHFR 677T polymorphism modulates posterior cingulate cortex-anchored structural covariance strength independently of white matter integrities.
The MTHFR C677T variant was significantly associated with Hcy concentrations.
The MTL of the baseline image was then mapped onto the corresponding follow-up image to measure volume change ( ΔMTL ) .
The MT + MG and MT + sham groups showed greater improvement in manual dexterity and daily function than the MT group did.
The mTOR pathway is dysregulated in a number of human pathologies including cancer , diabetes , obesity , autoimmune disorders , neurological disease and aging.
The mTOR signaling pathway is one of the major regulators of aging as suppression of this pathway prolongs lifespan in model organisms.
The MTT increase indicates significant structural changes corroborated by microscopy studies in animals or humans.
The MUC1 transmembrane glycoprotein is aberrantly overexpressed in diverse human carcinomas and has been shown to inhibit apoptosis induced by genotoxic agents.
The much desired and much needed prospective , double-bind , randomized , placebo-controlled trials with adequate follow-up and sample size have not yet been performed.
The mucosal healing ( MH ) rate at week @number@ was @percent@.
The multidimensional actions of NO species are , in part , mediated by their redox nature.
The multidimensionality of the host factors contributing to allostasis in the oral cavity is illustrated with an example on changes occurring in puberty.
The multi-domain MCI is the one that evolves directly into AD , not the amnestic MCIs.
The multi-facet nature of self-face-specific activation may hold potential as the basis for a multi-dimensional diagnostic tool for the cognitive system.
The multifactorial nature of nocturia supports the delivered management and treatments being targeted to underlying etiologies in order to optimize women's symptom management.
The multifactorial nature of telomere length ( TL ) regulation increases the perplexity of studies in the field.
The multifactorial nature of variables affecting sleep in old age cannot be overstated.
The multifunctional cosmetic formulation studied can be suggested to preventing signs of aging and improving skin conditions.
The multifunctional roles of SASP would depend on the cell type and their physiological nature.
The multigenerational living arrangements were compared with independent living in a dispersed ethnic community and in an ethnic cluster of public housing.
The multimorbidity frailty index included deficits from outpatient and inpatient diagnosis.
The multimorbidity trajectories affected later physical functioning , depressive symptoms , cognitive function , and life satisfaction.
The multiparametric correction equation has been modified accordingly.
The multiple group-based trajectories analysis approach was applied to identify the trajectory groups.
The multiple possible diagnoses associated with this symptom make correctly attributing back pain to a specific disease difficult.
The multiple regression analysis models confirmed a weak , independent contribution of TL to both RBC and WBC.
The multiple regression analysis showed that the SMI was negatively associated with visceral obesity in both sexes.
The multisensory training approach yields an improvement of balance in the elderly , which reduces the risk of falls.
The multisystem nature of these myriad changes strongly suggest that the ageing process itself is stimulated in these patients.
The multi-target iron chelator , M30 , has all the properties of ladostigil , but is not an acetylcholinesterase ( CHE ) inhibitor.
The multitude of variables that come with advanced age means that the management of pruritus in the elderly poses a particular therapeutic challenge.
The multivariate analyses were repeated after @number@ year.
The multivariate analysis of senescence markers by laser scanning cytometry offers a promising tool to explore the potential anti-aging properties of a variety agents.
The multivariate analysis revealed that in both sexes survival to age @number@ y was predicted independently by legitimacy and paternal occupation.
The multivariate analysis showed higher probability of being hospitalized among the elderly , but not for risks for acute morbidity and ambulatory care.
The multivariate analysis was based on binomial and multinomial logistic regressions.
The multivariate association only showed significant results among participants aged less than @number@ years old.
The Multivariate Cox proportional hazards model was used to determine independent prognostic factors associated with DFS and OS.
The multivariate linear regression model of predictors of well-being in older age also confirmed differences between urban and rural elderly residents.
The multivariate log-binominal regression model was used to compare the prevalence of H. pylori infection between seven geographic areas.
The multivariate logistic regression model was used to analyze data collected from samples.
The multivariate regression analysis revealed that components of MS ( systolic blood pressure and waist circumference ) are stronger predictors of LVM than MS itself.
The municipalities with populations above @number@ thousand inhabitants reported @percent@ of the cases.
The municipality health care service should implement such activity centers with specialist nurses in dementia care together with volunteers.
The murine model has been widely employed for investigation of immunity to influenza virus infection.
The muscarinic agonist carbachol and the M₂-preferential agonist oxotremorine also generated ATP release , which was antagonized by the M₂-specific agent methoctramine.
The muscle cell is multinuclear and each nucleus controls transcriptional activity in the surrounding territory of cytoplasm called myonuclear domain ( MND ) .
The muscle co-contraction was evaluated using the co-contraction index ( CI ) .
The muscle oxygenation parameters and tHb were continuously monitored by using near-infrared spectroscopy.
The muscle quality index ( MQI ) was recently recommended as an ideal evidence-based assessment of functional status in older adults.
The muscle sizes showed gender differences and a muscle-specific correlation with body weight , but not with age.
The muscle strength , in septuagenarians , and cardiorespiratory capacity , in septuagenarians and octogenarians contributes significantly to the self-perception of physical health.
The muscle tensile related to hand grip movement decreases with age.
The muscular gap was repaired employing a gore-tex mesh while the external covering was made by a pedicled perforator fasciocutaneous anterolateral thigh flap.
The muscular tension , motor function ( GMFM ) , functional independence ( WeeFIM ) were observed after treatment.
The musculoskeletal system functions because of the precise and coordinated assembly of its components , namely bones and joints , muscles , tendons and ligaments.
The mutant LA triggered a frequent and severe nuclear dysmorphy that occurred independently of prelamin A processing , as well as increased histone H3K9 acetylation.
The mutant proteins likely interfere with general mitochondrial biogenesis in a dominant-negative manner , which secondarily destabilizes mtDNA.
The mutated huntingtin is ubiquitous in somatic tissues , yet the pathologic changes are apparently restricted to the brain.
The mutated patients show an earlier onset of clinical manifestations as compared to CCM1 / CCM2 mutated patients.
The mutation frequency and the associated clinical characteristics were analyzed.
The mutation frequency of COQ2 is @percent@ in a Chinese MSA population.
The mutation frequency of SQSTM1 was @percent@ in Chinese patients with SALS , which was lower than those in other racial populations.
The mutation ( g.877C > T , p.P23L ) has been previously reported in a Chinese frontotemporal dementia patient.
The mutation is localized at the last nucleotide of exon @number@ and thus is predicted to cause aberrant splicing.
The mutation responsible for Hutchinson Gilford Progeria Syndrome ( HGPS ) causes abnormal nuclear morphology.
The mutation resulted in a truncated protein.
The mutation retaining enzymatic activity ( G37R ) was phenotypically indistinguishable from controls.
The mutation spectrum of SQSTM1 in Chinese patients with SALS remains unknown.
The mutations were not found in our study , suggesting that they are not a common cause of PD in South African patients.
The mutation targeting and the codon bias allow B cell CDRs to diversify by specifically accumulating nonconservative changes.
The mutation was inserted in the mouse genome by homologous recombination in mouse embryonic stem cells.
The mutation was not present in SNP databases and was also not found in @number@ control individuals.
The MVC and hand grip power were meaningfully greater in the young group than in the elderly group.
The MVs of senescent , cultured ECs , and those present in the plasma of elderly subjects , promote vascular calcification.
The MWT identified a high-frequency band as the main oscillator , which frequency ( 150-155 Hz ) was unaffected by age.
The mycosporine-Gly extract , but not the other MAAs , had strong antioxidant activity in the @number@ , ( DPPH ) assay.
The myelinated axons within WM are the structural foundation for efficient neurotransmission between cortical and subcortical areas.
The myelodysplastic syndrome ( MDS ) is a clonal hematologic disorder that frequently evolves to acute myeloid leukemia ( AML ) .
The mylohyoid bridging is a hyperostotic variation representing formation of bony bridges over the mylohyoid groove.
The myoblasts was grouped as young control , SIPS-induced , TRF control , TRF pretreatment , and TRF posttreatment.
The myocardial hypoenhancement area in the delayed contrast-enhanced effect suggests microvascular obstruction.
The myocardium was contoured , and the regional RT dose was calculated.
The myocardium was extensively transduced with microdystrophin to significantly prevent the development of fibrosis , and expression persisted for the duration of the study.
The myometrium is active through a woman's entire life , not just during pregnancy.
The myths of paramedic glories past tend to add to the confusion of graduates.
Then , 10mg oral MPH was given to the subjects and the same metabolite levels were measured after an interval of 30min.
The N15D / N71D mutant shows only minor additional effects when compared with the N15D mutation , supporting that deamidation of N71 induces negligible effects.
The N450 , a measure of conflict processing , was found to be sensitive to both stimulus and response conflict.
Then a better attention and qualification of GPs with regard to the recognition of MCI might be achievable.
The nAChR subtype selectivity was probed using α7-nAChR selective inhibitors MLA and ( R , S ) -dehydronorketamine and α3β4-nAChR specific inhibitor AT-1001.
Then , activities of swallowing muscles during normal swallowing with different volume of bolus were measured using MMG signal.
The NAD ( + ) -dependent histone deacetylase , Sirt1 , has been implicated in the ageing process.
The NAD ( + ) depending enzyme SIRT1 regulates the mitochondrial biogenesis , fat and glucose metabolism through catalyzing the deacetylation of several metabolism-related protein-substrates.
The NAD ( + ) / NADH ratio in WI38 / hNaDC3 cells was also decreased.
The naive cell deficiency is not related to a deficiency in IL-7 or its receptor.
The Na-K-2Cl cotransporter ( NKCC2 ) was downregulated by HSD in wild-type mice , but it increased in TG mice.
The Nakuru Posterior Segment Eye Disease Study is a population-based sample of @number@ participants aged ≥50 years , enrolled in 2007-2008.
The NALCC was significantly thicker than the CALCC ( P < @number@ ) and TALCC ( P < @number@ ) .
Then , all the visual targets were processed.
Then , alterations of the molecular pathways regulating osteogenesis are addressed.
The nanoleakage was observed by SEM with a backscattered electron detector.
The nanoparticles showed a size of 170-225 nm.
The narrow cytokine secretion pattern was the most striking difference between elderly and younger adult age groups.
The narrower the frame , the more aesthetically pleasing and youthful the gaze appears.
The NART and the Schonell had a strong linear relation , allowing for the imputation of NART scores based on Schonell performance within @number@ study.
The nasal choroid appeared thinner than in the temporal area ( analysis of variance , P < @number@ ) .
The nasal orbicularis fibers are released and the fat compartments are released and sewn to the midface fat using 6-0 transcutaneous sutures.
Then , a several group questions were asked them about their health status , how they managed their medication and their assessment about the applications.
The NASH-HCC patients exhibited a lower OXY than the NASH patients , probably due to the effects of aging.
The NASH-HCC patients tended to be older and exhibited a diminished anti-oxidative function.
The nasolabial fold , the tear trough and the labiomandibular fold represent an anatomical border between adjacent fat compartments.
Then , a three-way classification based on the principal components is conducted.
The National Alzheimer's Coordinating Center's Uniform Data Set implemented a Spanish neuropsychological battery.
The national and regional dialysis and transplant registers currently provide partial data on this phenomenon , but our information is incomplete.
The National Center of Neurology and Psychiatry provided resource-related information in comformance with the living will of individuals and the Research Resource Network.
The National Danish Registry of Medicinal Products Statistics was used to identify all claimed prescriptions for glaucoma medication and antihypertensive drugs.
The national health insurance system allows each member of the population to receive high-quality medical care.
The National Hospice Service Program has developed five principles to the practice of palliative care in China.
The national incidence of SE was highest at @number@.78patients / 100 , 000 / year in @number@
The National Institute on Aging-Alzheimer's Association revised criteria for AD provided a framework for this new thinking.
The National League for Nursing's Advancing Care Excellence for Seniors ( ACES ) project has addressed this challenge.
The National Notifiable Diseases Surveillance System received @number@ notifications of diseases transmitted by mosquitoes in Australia from @date@ to @date@ .
The National Research Council ( CNR ) , Neuroscience Institute , Aging Branch ( Padua ) is the promoting center.
The nationwide cancer statistics in this paper will provide essential data for evidence-based decisions in the national cancer control program in Korea.
The natural decline of melatonin levels with aging strongly contributes to the development of neurodegenerative disorders.
The natural extension is to directly apply the JPM to county-level cancer incidence data.
The natural history and penetrance of these mutations in the elderly is controversial and inadequately studied.
The natural history of ASCS is quite benign.
The natural history of cSDH remains unclear and is analysed only in case reports or very small case series.
The natural history of GO consists of two phases : an active inflammatory phase and a static phase.
The natural history of life span cognitive performance and its late-life determinants have been studied from an array of perspectives.
The Naturalistic Action Test was carried out after the patient had completed their routine assessment in the clinic.
The natural products seem to be safer and more biocompatible to human tissue.
The natural vitamin E analog α-tocopheryl phosphate ( αTP ) modulates atherosclerotic and inflammatory events more efficiently than the unphosphorylated α-tocopherol ( αT ) .
The nature and impact of these changes warrant further investigation.
The nature creates a number of mechanisms , which defend the organism from cosmic rays and free radicals as consequence.
The nature of knowledge , i.e. sensory-dependent or abstract , is controversial.
The nature of the dose response in and adjacent to the therapeutic zones , over the past decade has received considerable advances.
The nature of the link between arterial stiffness and quality of life in older people merits attention.
The nature of the TDP-43-mediated neurotoxicity associated with these diseases is not yet understood.
The nature of this relationship between age and outcome of a primary prevention ICD in patients with nonischemic systolic heart failure warrants further investigation.
Then CHIP-QPCR was conducted to analyze histone modifications of P66SHC between young cells and aging cells.
Then , cluster characterisation based on socio-demographic and linguistic performance was tested ( fluency , naming , syntax and spelling ) .
The NCMS has improved the health-care utilization of rural elders , and they have the highest satisfaction with it among all age groups.
The nCMSP was not associated with any gait variables.
Then conditioned medium was collected and transferred to non-irradiated hSC for time course studies.
The NC was delayed ( > 48 h ) in @number@ patients ( @percent@ ) ( median time to consultation , @number@ days ) .
Then diabetic ketoacidosis , angiopathy , and neuropathy were examined as diabetic complications for their involvement in cognitive impairments.
Then DMR threshold was determined from methylation probability model.
The near-epidemic prevalence of incontinence in women continues to generate interest in the functional anatomy of the pelvic floor.
The necessary response to these changes is discussed with attention to methods of monitoring and recommendations for providing supportive care.
The necessity of this phenomenon , since A. Weismann , has been justified by the need for population renewal according to ecological and evolutionary requirements.
The need for an increased role of social workers in community development interventions is explored and strategies are suggested.
The need for a tissue or other diagnostic biomarker is reinforced.
The need for domiciliary dental care has increased with the aging of Japanese society.
The need for imposing measured inlet velocity profiles would seem to be relevant only for those cases where the CCA is severely truncated.
The need for interdisciplinary training and increased communication and collaboration among providers was emphasized , including the need for clarification of provider roles.
The need for joint replacement is expected to increase as this population develops degenerative changes from aging and avascular necrosis ( AVN ) .
The need for physicians with training in clinical neurosciences will grow.
The need for post-surgical wound care is sharply on the rise.
The need for rehabilitation strategies to optimize function and reduce disability is a clear priority for research to address this public health challenge.
The need for social workers with a specialization in gerontology has become a global priority.
The need for standardized procedures when collecting and reporting epidemiological data on hearing loss has become evident.
The need for strategies against disability has led researchers to look for the most relevant risk factors potentially determining or accelerating the disabling cascade.
The need for therapies that can protect and / or improve mitochondrial function is obvious.
The need for this surgery has become an important socioeconomic problem and may affect health-care providers , especially in aging societies.
The need to alter practice approaches includes vascular access techniques and the administration of intravenous medications , fluids , and blood components.
The need to ensure that research into older peoples ' health is effectively translated to policy is immediate.
The need to reduce unnecessary hospitalization will become only more urgent as the population ages and healthcare expenses continue to escalate.
The need to report more thoroughly on characteristics of young and old participants in future studies is also emphasized.
The NEET proteins mitoNEET ( mNT ) and nutrient-deprivation autophagy factor-1 ( NAF-1 ) are required for cancer cell proliferation and resistance to oxidative stress.
The negative association between duration of HRT and CAC was evident in all age groups of older women.
The negative association of BMI with telomere length was stronger among younger than older participants ( P for interaction , @number@ ) .
The negative association was particularly strong for leisure , culture or sports clubs , and for family or school reunion.
The negative control group cells received no treatment.
The negative correlation between paraoxonase lactonase activity and homocysteine level was noticed.
The negative effect of aging on IGFBP2 mRNA levels in visceral WAT was confirmed in obese men.
The negative effect of hypertension on lifelong cognitive ageing was all mediated via MRI-derived brain WMH.
The negative effect of WMH on ' g ' was linear and greater in the older sample due to greater WMH burden.
The negative effects of depression on resilience related to emotional regulation were countered by low hopelessness but only in the young adults.
The negative effects of diabetes on kidneys , nerves , and vessels are well established.
The negative effects of dysglycemia , leading to cardiovascular complications , are amplified during aging.
The negative effects of secondary tasks on balance control in those with peripheral visual losses become more apparent under somatosensory perturbations.
The negative externality of peer competition is experienced in all cities , fairly independent of their population size.
The negative impact of ageing was also assessed by the prevalence of comorbidities.
The negative influence of the advanced maternal age has been thoroughly demonstrated , while the paternal age has attracted comparatively less attention.
The negative profiles are primarily due to more negative physical characteristics ascribed to older adults and more negative cognitive characteristics ascribed to adolescence.
The negative relation between metabolism and life span is a fundamental gerontological discovery well documented in a variety of ontogenetic and phylogenetic models.
The negative relationship between age and numeracy was mediated by need for cognition.
The negative relationship between WMH and late-life intelligence is linear and increases with age.
The Ne-IC was smaller in the older than the younger subjects for both speed and accuracy instructions.
Then , electrophysiological recordings permitted the classification of sleep stages according to the observed EEG patterns.
The nematode Caenorhabditis elegans ( C. elegans ) has four Sir2 paralogs , sir-2.1 , sir-2.2 , sir-2.3 , and sir-2.4.
The neodymium : yttrium-aluminum-garnet ( Nd : YAG ) laser is a popular non-ablative treatment used for skin rejuvenation.
The NEO-Five Factor Inventory and the Depressive Experiences Questionnaire were administered.
The neolignan ( DDE ) caused a @percent@ increase in lipid accumulation in murine 3T3-L1 cells.
The neonatal line is usually the first accentuated incremental line visible on the enamel.
The nephrology community should pay more attention to bone fractures in dialysis patients.
The nephrosclerotic patient showed severe hyalinosis with luminal narrowing of small arteries directly inducing glomerulosclerosis.
The nerve center responsible for controlling our circadian rhythm is located in a cluster of cells known as the suprachiasmatic nucleus in the hypothalamus.
The nervous system , once exposed , has a limited capacity of self-repair.
The net age effect on AMI mortality increased exponentially.
The net benefit and ROI were estimated for each of the interventions.
The net societal budget impact would be US $ 5.8 billion and the incremental cost-effectiveness ratio US $ 27 , 411 / QALY gained.
The network of protein-protein interactions among the BCL-2 protein family plays a critical role in regulating cellular commitment to mitochondrial apoptosis.
The networks are represented by graphs , in which nodes correspond to the areas , and edges denote statistical associations between them.
The network structure decreases flexibility from conception onward due to differentiation and cumulative responses to environment ( exposome ) .
The neural centers that support cognition and behavior are the \ "hubs \ " defining the salient geographic landmarks of the cerebral topography.
The neural mechanisms that underlie these processes are not well understood despite many decades of research.
The neural mechanisms underlying lateral spatial interactions are a matter of debate , and various hypotheses have been proposed.
The neural organization of cognitive processes , particularly hemispheric lateralization , changes throughout childhood and adolescence.
The neural substrates associated with Lesch-Nyhan disease remain poorly understood.
The neurobiological correlate of this variation is not well described.
The neurobiological mechanisms modulating stress may share common pathways with appetite regulation and consequent obesity.
The neuroinflammatory response , produced by these challenges results in increased and prolonged production of pro-inflammatory cytokines in the otherwise healthy aged brain.
The neurological examination revealed supranuclear vertical gaze palsy , poor face miming , and a mild balance deficit.
The neurological underpinnings of PTSD have been well characterized , but the causal relationships with the traumatic event are still unclear.
The neurologist diagnosing early septic encephalopathy may therefore contribute to the optimal management of septic patients.
The neuromodulation of motor excitability has been shown to improve functional movement in people with central nervous system damage.
The neuromuscular junctions ( NMJs ) become smaller and less abundant in aging rat laryngeal muscles , with evidence of functional denervation.
The neuromuscular junction suffers at cellular and molecular level , with possible implications of various cell components , mediators and oxidative stress.
The neuromuscular system is comprised of individual motor units , each of which features a single motor neuron and all the muscle fibers it innervates.
The neuromuscular system is one of the largest and most vital organ systems of the body.
The neuromuscular system provides the necessary components for all locomotion , and is thus a logical choice for preventative therapies to target.
The neuronal cells expressed numerous genes associated with sub-regions within the brain thus suggesting the usefulness of our in-vitro model.
The neuronal losses and dendrite structural changes occur in select regions of the brain.
The neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques-which are frequently surrounded by dystrophic neurites-and intracellular neurofibrillary tangles.
The neuropathological hallmarks of the disease are extracellular amyloid-β ( Aβ ) plaques and intraneuronal hyperphosphorylated tau aggregates.
The neuropathology of DS is complex and likely results from impaired mitochondrial function , increased oxidative stress , and altered proteostasis.
The neuropathology underpinning head injury is becoming increasingly better understood.
The neuropeptide oxytocin has multiple prosocial effects when administered intranasally in humans and there is growing interest in its therapeutic potential in schizophrenia.
The neuroprotective action of OXM , however , has not been thoroughly investigated.
The neuroprotective effects of estrogen have been demonstrated consistently in cellular and animal studies but the evidence in women remains conflicted.
The neuroprotective effects of memantine and vitamin D may potentiate each other , with benefits for cognition.
The neuroprotective effects of these flavonoids in cellular were evaluated in vitro by this cell model.
The neuroprotective mechanisms might involve antioxidative effects , maintenance of mitochondrial function , and regulation of caspase-3 and tyrosine hydroxylase expression and activity.
The neuroprotective role of adenosine and the deregulation of adenosine receptors in Alzheimer's disease ( AD ) have been extensively studied in recent years.
The neuropsychological assessment revealed impaired delayed memory in AE.
The neuropsychological battery from the National Alzheimer's Disease Coordinating Center is designed to provide a sensitive assessment of mild cognitive disorders for multicenter investigations.
The neuropsychological predictors consisted of the performance on tests of episodic memory , working memory , switching , inhibition and flexibility.
The neuropsychological profile of adult HFA / AS patients diagnosed late in life is compatible with that of previously investigated HFA / AS populations.
The neuropsychological protocol showed a significant ecological validity as @number@ of the cognitive factors explained @percent@ of the variance on Instrumental Activities of Daily Living.
The neuropsychological test battery covered @number@ major cognitive domains by several well-established tests each.
The neuropsychological tests and the proposed cutoff values might be used for the clinical assessment of older adults with low formal education.
The neurorestorative activity has been identified as being related to the ability of the drug to activate hypoxia-inducible factor ( HIF ) by inhibiting prolyl-4-hydroxylase.
The neurosurgical prevalence is even more striking in cervical or intradural procedures.
The neurotrophin Nerve Growth Factor ( NGF ) is essential for the maintenance and differentiation of basal forebrain cholinergic neurons.
The neurotrophin receptor p75NTR has been proposed to mediate Aβ-induced neurotoxicity ; however , its role in the development of AD remains to be clarified.
The neurotropic parasite Toxoplasma gondii infects one third of the world population , but its effect on memory remains ambiguous.
The neutral effect of rosuvastatin treatment on clinical outcomes was not modified by baseline telomere length.
The neutralization procedure did not enhance the ceramic / resin cement bond strength.
The neutrophil morphology observed by electron microscopy confirmed this trend.
The neutrophil stimulated oxidative burst in the injured elderly subjects at time periods @number@ @number@ and @number@ was not significantly different from the NIY controls.
The Ne was examined by means of ICA and PCA , yielding a prominent independent component on error trials , the Ne-IC.
The new BIA equation showed a PE close to RMSE of the estimate with no significant bias.
The Newcastle-Ottawa quality assessment was used.
The Newcastle-Ottawa Scale and Physiotherapy Evidence Database assessed methodological quality of all studies.
The new concept of social health suggested by Huber and colleagues seems helpful to make such a shift.
The new dermal implant Uma Jeunesse® was compared to Juvéderm® in this split-face study.
The new distribution is characterized by @number@
The new epigenetic landscape we describe may provide a mechanism for the regulation of hematopoiesis and may contribute to leukemia development.
The new FD2 test gives comparable values to the original FD2.
The new gait parameters therefore may be complementary to existing methods and may have potential as biomarkers for specific disorders.
The new gait parameters were compared to accidental falls , mental state and co-morbidities.
The new genetic factors in AUD were not related to MDD.
The new ICD-10-CM ( M62.84 ) code for sarcopenia represents a major step forward in recognizing sarcopenia as a disease.
The new impairments led to decreased physical and mental health.
The new information generated has increased our understanding of the impact of health campaigns on organizational behavior.
The new Jouk scoring method was then compared to other commonly used systems ( e.g. Shulman , Tuokko , Watson , Wolf-Klein ) .
The new kernel method is mathematically equivalent to isotropic heat diffusion , kernel smoothing and recently popular diffusion wavelets.
The newly defined SCINIB category of ADNI subjects is more prevalent than AD preclinical stage individuals.
The newly discovered 5-hydroxymethylcytosine mediates DNA demethylation , is highly abundant in the brain , and is dynamically regulated by life experiences.
The newly gained edges were mostly confined to the temporal and paralimbic regions , which manifest demyelination of SWM already in mild AD.
The newly identified mutant as well as known mutants rendered neuronal cells susceptible to oxidative stress.
The newly identified SGG six-marker panel and associations found with precancerous lesions should be further explored.
The newly proposed clinico-radiological diagnostic criteria are based on characteristics of pain , joint mobility , and radiological assessment.
The new metric may lead to improved understanding of atherogenesis.
The new oral anticoagulants ( NOAC ) dabigatran , rivaroxaban and apixaban have been shown to be non-inferior to VKA for stroke prevention in AF.
The new pseudophakic norm can be used clinically to predict the straylight value after lens replacement and as a reference criterion for clinical studies.
The new service provides comprehensive health care , including the management of physical co-morbidity and a recovery orientation.
The new task's parameters are reliable , and have very high correlations with the existing task.
The new task's parameters perform as expected with respect to age and intelligence differences.
The new template includes the majority of the fornix from the hippocampal formation to the subcallosal region and the thalamus / hypothalamus.
The new U-Gompertz models are special cases of the Unified-Richards ( U-Richards ) model and thus belong to the Richards family of U-models.
The new ward received additional resources to establish the model of care , including a broader skillmix.
The new workflow of an imaging department entails a reduction of @number@ % of the total completion time.
The next challenges , alternative strategies , their limitations and prospects are also discussed.
The next challenge will be to develop interventions and supplements that can abrogate the deleterious effects of senescent cells while preserving their beneficial effects.
The next decade will likely bring newer antivirals and vaccines to the forefront.
The next functional imaging technique widely used in the diagnosis of cognitive disorders is single photon emission computed tomography ( SPECT ) .
The next meeting is planned for the fall of @number@ in the same venue.
The next morning , at @number@ am , the subjects had to drive in a simulated monotonous driving environment for @number@ h.
The next morning , participants reported their sleep quality the previous night and their current experience of morning pain.
The next most common criterion was low physical activity ( expenditure of kcal / week ) .
The next question is whether these alterations are common to other geriatric diseases and / or preexist before the clinical onset of the diseases.
The next step is to conduct sequencing of top significant loci in a subset of samples with overlapping ROHs.
The next step is to use the validated framework in evaluating actual priority setting at the different levels.
The next Symposium is anticipated in @number@ in Jeju , Korea.
Then , family members iteratively moved through all the other key phases in the process until a time to let go became evident.
The NF-kappaB family of transcription factors regulates genes that are critical for inflammation and immunity.
The NF-kappaB signaling pathways have a critical role in the development and progression of various cancers.
The NFL thickness and neurofilament protein were reduced in 24-week-old SOD1-deficient mice.
Then for the following @number@ months , eight biweekly telephone follow-up calls were carried out.
The NFT pathology of AD is associated with DTI alterations involving the medial temporal limbic connections and medial parietal white matter.
The NF-κB family of transcription factors is essential for an effective immune response , but also controls cell metabolism , proliferation and apoptosis.
The N-glycan fingerprint of membrane proteins was obtained using DNA sequencer-assisted fluorophore-assisted carbohydrate electrophoresis ( DSA-FACE ) .
The NHANES was composed of a civilian , noninstitutionalized community , and the NHATS comprised Medicare beneficiaries in the contiguous United States.
The NHATS included @number@ @number@ respondents aged @number@ years and older with dementia status assessment.
The NIA-AA initiative also built upon research criteria for AD proposed by the International Working Group ( IWG ) in @number@ and updated in @number@
The niche is essential to support HSC function and to maintain a correct balance between self-renewal and differentiation.
The NICHE ( Nurses Improving Care for Healthsystem Elders ) program provides a framework to create an aging-sensitive care environment in the critical care setting.
The niche provides protection and produces signals that guide stem cell division and differentiation.
The night shift effect was present even @number@ days after ending night shifts.
The NIH Trauma Research Roundtable was convened on @date@ to @number@ @number@
Then , in a second section , the general practitioner expresses his / her own view about the frailty status of the individual.
The Nintendo Wii was the most prevalent gaming system ( @percent@ or 27 / 30 studies ) used in the identified studies.
Then , it presents evidence pertaining to the use of ketamine , aripiprazole , brexpiprazole , quetiapine , and methylphenidate in the treatment of LLD.
The nitric oxide ( NO ) pathway is a key regulator in the cardiovascular system and modulates vascular tone and myocardial performance.
The nitrite reaction with deoxyhemoglobin was followed by chemiluminescence , electron paramagnetic resonance and visible spectroscopy.
Then joint model is estimated where attrition is considered.
The NKA content was also contrasted between subgroups below and above the median age of @number@ yr.
The NKA content was @percent@ lower in the older ( 69-81 yr ) than in the younger ( 55-68 yr ) subgroup.
The NKT cells from the LTNPs showed higher proliferation ability.
The NLR was directly related to the prevalence of CAD ( P = @number@ ) and severe CAD ( P < @number@ ) .
Then MALDI-MSI was used to study age modifications.
Then , NFTs spread from the entorhinal cortex to the limbic and neocortex.
Then , NOA generates two alternative reference sets to statistically rank the enriched functional terms for a given biological network.
Then , @number@ ml of the Licatack shampoo was placed onto the top of each child's head.
Then , @number@ people as the selected residents were enrolled , which was figured out through the random cluster sampling procedure.
Then @number@ specimens of dentin-resin composite were fabricated in each group.
The no-contact control group members were also recreated to participate in health checks and surveys for data collection purposes.
The NoDiag-NoSympt group had the lowest \ "not seeking care when needed \ " and \ "difficulty in adhering to treatments. \ "
The NoDiag-Sympt group reported the highest \ "not using preventive care \ " and \ "not seeking care when needed. \ "
The nomogram estimates the absolute HbA1c reduction from baseline using the type of DPP-4 inhibitor , baseline values of HbA1c and fasting glucose.
The nonclinical γ-secretase inactive PS1-D257A mutation did not alter gene expression in either cell line.
The nondemented ALS patients displayed loss of VGLUT-1-positive axon terminals in the putamen , but those were relatively spared in the caudate head.
The non-dominant hand was subjected to three trials of impulsive loading with arm muscles precontracted to @number@ @number@ or @percent@ of maximum pre-cocontraction levels.
The non-enzymatic reaction between glucose and protein can be chemically reversed by transglycation.
The Non-Homologous End Joining ( NHEJ ) pathway repairs a majority of DSBs in vertebrates.
The non-invasiveness and improvement in imaging technology facilitates the emergence of new screening tools.
The non-linear relationships observed with eGFRcr underscore the limitations of creatinine as a predictor of frailty outcomes in older individuals.
The nonmedicinal intervention for postmenopausal women is mainly exercise.
The nonparametric Mann-Whitney U test was used to evaluate the power of differentiating control from PD subjects for both image modalities.
The nonpharmacological interventions seem to be an efficient , inexpensive , and easy tool for family caregivers.
The non-racquet arm can act as an internal control for the exercising racquet arm without confounding factors , e.g. genotype.
The non-random distribution of detected mosaic events throughout the genome suggests common mechanisms could influence the formation of mosaic events.
The non-receptor tyrosine kinase Abl is linked to neuro-inflammation in AD.
The nonresurfaced epidermis helps tissue to heal rapidly , with short-term postoperative erythema.
The nonshared environmental correlations ranged from @number@ to @number@
The non-targeted approach revealed a specie-specific lipidomic profile that accurately predicts the animal longevity.
The nontoxic excipients and sophisticated material engineering of SLNs tailor the controllable physicochemical properties of the nanoparticles for GI penetration via mucosal or lymphatic transport.
The normal aging process and weight gain are regularly blamed.
The normal aging process did not significantly change LVSIsys , whereas LVSIdia progressively and consistently increased with age.
The normal cellular function requires communication between mitochondria and the nucleus , termed mitochondria-to-nucleus retrograde signaling.
The normal condition was not restored after six months of chemotherapy.
The normality values ranged from @number@.7° to @number@.3° in the sagittal plane , and from @number@.6° to @number@.2° in the frontal plane.
The normalized diameters were similar between both genders within each age group ( p > @number@ ) .
The normalized effective reflecting length did not alter with aging until @number@ years of age and increased remarkably thereafter in men and women.
The normalized total hippocampal volume accounted for @percent@ of the variance in recollection performance.
The normal level of serum sulfatide in kidney transplant recipients might affect platelet function , and contribute to the reduction of cardiovascular disease incidence.
The normal map that is extracted through shape from shading method is composed of face contour and skin fine-structure parts.
The normal model reproduced measured volumes within @number@ SD , as well as most metrics of regional mechanics.
The normal neonatal canine brain exhibits marked differences from that of the mature brain.
The normal range for serum testosterone is @number@ to @number@ ng / dl.
The normal ranges for ALT have been updated and validated considering the metabolic covariates in the various ethnic districts.
The normal upper limit for DeltaSBP was @number@ mmHg in this population , the prevalence of sIAND by≥16 mmHg was @percent@.
The normative database is available in Database S1.
The normative values demonstrate that a decrease in endurance time is expected with increasing age.
The norms can be used in clinical practice to identify patients at increased risk for adverse outcomes.
The norms were built from a sample ( n = @number@ ) of community-dwelling French speaking residents from Québec aged @number@ and older.
The Northern Manhattan Study ( NOMAS ) includes @number@ stroke-free participants from a largely Hispanic multi-ethnic urban community.
The Northwestern University SuperAging Project recruits community dwellers over the age of @number@ who have unusually high performance on tests of episodic memory.
The Norwegian and Canadian group self-enhanced their perceptions of psychosocial loss based on harmonious social relationships and being part of a larger social group.
The notion of dietary balance is fundamental to health yet is not captured by focusing on the intake of energy or single nutrients.
The notion of the heterogeneity of aging goes along with the awareness that every person experiences aging differently.
The notion that prion-like spreading of misfolded α-synuclein ( α-SYN ) causes Parkinson's disease ( PD ) has received a great deal of attention.
The noun-pair lookup ( NP ) task was used to evaluate strategic shift from visual scanning to retrieval.
The novel anticoagulants are an alternative to warfarin in patients with AF.
The novel finding of an increase in functional muscle mass suggests that smoking cessation could increase functional capacity.
The novel finding of this study was that muscle architecture and tendon properties explained interindividual differences in mobility.
The novel lipidomic biomarkers are reviewed in an effort to underline their role in diagnosis , in prognostic characterization and in prediction of therapeutic outcomes.
The novel method enabled determination of each Pls species in human plasma at the concentrations of @date@ .6μM.
The novel method for analysis of ion conduction mechanisms of ion channels can be easily used by means of IBiSA tools.
The novel model enables to simulate age-related changes of trimethylation of lysine @number@ at histone H3 and of DNA methylation.
The novel @number@ h postexercise transcriptome indicates substantial transcriptional activity potentially associated with the prolonged presence of leukocytes in the muscles.
The novel p.Lys91ArgfsTer8 mutation led to a frameshift causing the addition of @number@ new amino acids , including a premature stop codon at position @number@
The novel radio-frequency delivery device was used to heat the dermis between 41-43°C for five heat cycles.
The novel rehabilitation technique of performing light resistance exercise during blood flow restriction was also successful in overcoming the anabolic resistance to exercise.
The novel targeting vectors transduced HK with high efficiency and a remarkable specificity even in mixed cultures of HK and feeder cells.
The novel , two-step cosmetic formulation reduced the appearance of wrinkles and increased skin elasticity thus providing an effective anti-aging option for target wrinkle areas.
The Novelty-index remained non-significant.
The novel virus included hMPV and HBoV , which also played an important role in ARI.
Then participants , though informed of it , were asked to ignore their overflow.
Then participants were given @number@ milliseconds to complete the movement.
The NPM1 C-terminal domain was previously shown to bind nucleic acids.
The NQO1 polymorphism C609T has been associated with increased susceptibility to various age-related pathologies.
The NRC in PD was negatively and significantly correlated with duration of illness and disease severity assessed by UPDRS and Hoehn & Yahr stage.
The NRC showed significant positive correlation with normal aging and was slightly but significantly higher in women than in men.
Then region growing was applied to delineate LGN.
Then , research results were analyzed critically in order to select the best experiences available.
Then ROS generation and inflammatory and gene expression in HUVECs were evaluated by dihydroethidium staining and real-time reverse transcription-polymerase chain reaction analyses , respectively.
The NRSP is more likely to significantly improve the quality of life of one-child elders.
Then , SBS tests were conducted.
The NSHAP collected data from @number@ adults ( aged 57-85 ) .
The N-terminal hydrolysis was more efficient than the C-terminal one , but both abolished the ability of AAT to inhibit trypsin in an additive manner.
Then the biological age score was taken as a dependent variable and the chronological age as an independent variable for linear regression.
Then , the combined effect of SRH-global and SRH-age on depressive symptoms was further investigated.
Then the cream was removed and the first blood draw taken.
Then the epidermis was separated from dermis and lipid metabolism was investigated.
Then , the femur was mechanically tested to fracture in a sideways fall on the hip position to measure stiffness and strength.
Then , the food intake of the residents was measured by a precise food-weighing method.
Then the joint model uncovers the peak somewhat later in time , and also reveals secular improvement in life quality experienced by recent cohorts.
Then , the main and interaction effects of drinking and smoking on psychological distress were analyzed.
Then , the MCI group was divided into an amnestic MCI ( a-MCI ) and a multidomain MCI ( md-MCI ) group.
Then the mean and standard deviation of intensities of each layer were calculated.
Then , the mothers distributed the rather fluid product all over the hair thoroughly from their base at the skin until the free end.
Then , the participants listened to lists composed of five pairs of words in quiet and in 20-talker babble.
Then the PC-Pls and PE-Pls species in the plasma of both healthy subjects and patients with Alzheimer's disease were quantitated.
Then , the possible association between CT and some clinical features was evaluated by means of linear regression analysis.
Then , the recently developed technologies and approaches employed to encapsulate cells are summarized and compared in benefits and flaws.
Then there's a famous hoax against Pelias : Medea , pretending to rejuvenate the old tyrant , kills him.
Then the residual contaminants were analyzed , and adhesion characteristics were investigated.
Then the RF current was applied to the elevated muscle flap until the target temperature of 60°C to 80°C was reached.
Then , the same tests were performed on a foam support.
Then , the selected genes were integrated with protein-protein interactions to construct time point specific network.
Then , the solid dispersion of trans-resveratrol with PEG or inclusion complexes trans-resveratrol / βCD were prepared and characterised by different methods.
Then , the subjects performed 2×3 repetitions at @percent@ 1RM to compare purely concentric and eccentric-concentric repetitions.
Then the surgical techniques of temporal and brow liftings must be considered and coupled with the techniques of lipostructure that are more and more practiced.
Then the two types of PSC can be differentiated , using standardized protocols , towards the cell type necessary for the regeneration.
Then they dived to @number@ msw for @number@ min with air tank.
Then , two radiologists scored the simulated trabecular architectures using the age-matched radiographs.
The nuclear factor erythroid 2-related factor @number@ ( Nrf2 ) signaling pathway provides cellular protection against oxidative stress.
The nuclear lamina is an interconnected meshwork of intermediate filament proteins underlying the nuclear envelope.
The nuclear lamina underlies the inner nuclear membrane and consists of a proteinaceous meshwork of intermediate filaments : the A- and B-type lamins.
The nucleolus is a compartment for the transcription of ribosomal RNA ( rRNA ) and assembly of ribosome subunits.
The nucleus is the defining feature of eukaryotic cells and often represents the largest organelle.
The nucleus was hydroexpressed and the capsular bag evacuated by irrigation / aspiration.
The null and non-null genotypes of GSTM1 and GSTT1 genes were determined by multiplex PCR.
The null hypothesis tested was that microtensile bond strength ( microTBS ) was not affected by oxalate treatment and dentin moisture during two evaluation periods.
The @number@.5th and @number@.5th percentile interocular difference tolerance limits for average RNFL thickness were @number@ μm and @number@ μm , respectively.
The @number@ adoptees alive in @number@ were similarly compared to all Danes using SMR as well as cause-specific SMR.
The @number@ aging conditions of adults with an intellectual disability include physical and mental health.
The @number@ American Gastroenterology Association Future Trends Committee report states that serum ALT levels remain constant with age.
The @number@'-AMP-activated protein kinase ( AMPK ) , which is a sensor of cellular energy , regulates neuronal survival and energy homeostasis.
The number and function of EPCs declines as part of aging-associated senescence , thereby potentially contributing to vascular pathologies.
The @number@ and @number@ g / kg mice were not evaluated due to early deaths.
The number and scope of DRPs identified by pharmacists was best represented by STOPP / START.
The @number@ and the @number@ untranslated regions ( UTR ) of the insulin genes are very well conserved across species.
The @number@ Beers Criteria identified more females , more White people , and a younger population with PIM.
The @number@ Beers Criteria only group had lower median unadjusted healthcare costs ( $ 7104 vs. @number@ p < @number@ ) .
The @number@ blue light-filtering IOLs best reproduced yellowing of the human lens at @number@ to @number@ years of age.
The @number@ brain structures were first defined in multiple ( n = 29 ) geriatric atlases.
The @number@ cases had multiple-system involvements , mainly the renal system.
The @number@ cases were divided into @number@ groups by age : 0-5 , 6-20 , 21-50 , and older than @number@ years.
The @number@ categories of change were : maintained low , decreased , increased , and maintained high.
The @number@ children ( @percent@ ) experiencing early AR had higher BMI , FMI , LMI and percent fat at @number@ years.
The @number@ cities were Buenos Aires , Bridgetown , São Paulo , Santiago , Havana , Mexico City and Montevideo.
The @number@ clusters that showed significant differences tended to be areas that are involved in visual-spatial and executive processing.
The @number@ C to T transition in the MTHFR gene is a genetic determinant for hyperhomocysteinemia.
The @number@ day boil and @number@ bar @number@ h autoclave produced similar transformation results , while the @number@ day boiling treatment revealed the greatest transformation.
The @number@ deg stimulus replaces the small , eccentrically viewed stimulus used in traditional HFP.
The @number@ dentate elderly who underwent clinical oral examinations at baseline and @number@ who participated in the follow-up were included in this study.
The @number@ groups did not differ in demographic characteristics , general cognitive functions and memory impairment.
The @number@ groups did not differ significantly in any demographic characteristics.
The @number@ groups were compared using t-test.
The @number@ groups were well matched at baseline.
The @number@ h systolic blood pressure ( SBP ) and other blood biochemical parameters were assayed for all patients.
The @number@ hypertensive patients were divided into four sub-groups according to the duration of hypertension.
The @number@ included trials comprised @number@ for older people and @number@ for older people with heart failure.
The @number@ informants were relatives , general practitioners ( GPs ) and home-based care workers.
The number in need of intervention was dramatically increased when overweight / obesity as a cardiovascular disease risk was considered.
The number is expected to increase by ∼1.5 fold over the next ten years due to an increase in aging population.
The @number@ item survey was answered from @date@ to @date@ , by @number@ randomly selected academic employees.
The @number@ kDa FK506-binding protein ( FK506BP12 ) , an immunosuppressor , modulates T cell activation via calcineurin inhibition.
The @number@ kHz reactance , resistance and phase were used as the major outcome variables.
The @number@ LBP patients showed varied deviations in pattern and excursion from the average of the healthy subjects.
The Number Line ( NL ) task requires judging the relative numerical magnitude of a number and estimating its value spatially on a continuous line.
The @number@ loci account for ∼2.7% of BMI variation , and genome-wide estimates suggest that common variation accounts for > 20% of BMI variation.
The @number@ major causes of vision loss in this population are briefly reviewed.
The @number@ mammalian HDACs are grouped into four classes.
The @number@ MCPH1 mutations were homozygous microdeletions of @number@ and @number@ bp , respectively , for which we were able to map the exact breakpoints.
The @number@ metabolites are components of key metabolic pathways regulating oxidative stress , inflammation , and nitric oxide bioavailability.
The @number@ month-old DJ-1 KO retinas were also characterized by a noticeable increase in RPE fluorescence to wild-type.
The @number@ NAFLD patients included patients with non-alcoholic fatty liver ( NAFL ; n = 14 ) and NASH ( n = 44 ) .
The number needed to treat and the effect size could not be calculated from the data provided.
The @number@ nm wavelength matches one of the water absorption peaks in the mid infrared band of electromagnetic energy.
The @number@ Objects Test is a reliable and valid very brief screening test that is suitable for primary care.
The @number@ Objects Test requires the recall of the locations of five everyday objects , immediately after placement and after a brief period of time.
The number of adults above sixty-five years of age in the United States will expand considerably over the next thirty years.
The number of Americans aging with disabilities will grow substantially in coming decades.
The number of bed days for @number@ and @number@ was estimated at @number@ and @number@ respectively , representing a @number@.1-fold increase.
The number of beds in SH units increased from @number@ beds in 1996 / 1997 to @number@ beds in 2010 / 11.
The number of births in these months exceeded the following two four-month data ( q2 = @time@ , p < 0.024 ) .
The number of blood vessels positively stained either to von Willebrand factor or to CD31 in dermis was decreased gradually with age.
The number of body rotations along the path affected MC performance in children more than in adults , and in women more than in men.
The number of bony depressions , distribution and amount of joint fluid and the presence of bone marrow changes were assessed.
The number of cancer survivors has been steadily increasing due in part to the aging population and advancements in cancer care and treatment.
The number of cancer survivors increases annually , because of advances in detection and treatment , and the aging and growth of the population.
The number of cases will increase as the baby boomer cohort ages and as the prevalence of chronic disease increases.
The number of cases with falls / fractures was @number@ in atypical antipsychotic users and @number@ in typical antipsychotic users.
The number of causal errors was higher in healthy older adults compared to AD patients but affective content attenuated the effect.
The number of cells comprising biological structures represents fundamental information in basic anatomy , development , aging , drug tests , pathology and genetic manipulations.
The number of cells of certain specificity may reflect the number and time point of previous antigen encounters and intrinsic age-related changes in the BM.
The number of centenarians is projected to rise rapidly.
The number of centenarians per @number@ is opposite to the percentage of people above @number@ decreasing from west to east.
The number of chronic diseases was @number@ ± @number@ per subject , whereas the number of drugs was @number@ ± @number@ per subject.
The number of correlations was greater among the gerontic aged people in comparison with the middle aged , especially among women.
The number of cosmetic procedures for facial rejuvenation has increased steadily over the past decade.
The number of deaths also decreased for esophageal cancer , stomach cancer , and chronic myeloid leukemia , although these results were not statistically significant.
The number of deaths from liver cancer has not declined even following various therapies.
The number of dental restorations was higher for women compared to men ; however , men had more caries than women.
The number of depressive symptoms is similar for those with subthreshold-level depression with comorbid anxiety , compared to case-level depression without symptoms of anxiety.
The number of drugs and age were the most significant factors.
The number of drugs in polymedicated people was @number@ ± @number@ versus @number@ ± @number@ in non polymedicated people ; p≤0.01.
The number of elderly diabetic patients who require chronic hemodialysis is progressively increasing in Japan.
The number of elderly patients with chronic pruritus has been gradually increasing in aging countries.
The number of elderly patients with hematologic malignancies has been steadily increasing with the aging of society.
The number of elderly people starting dialysis is continuously increasing.
The number of elderly persons , defined as those > 65 yrs of age , is the fastest growing segment of the U.S. population.
The number of environmental barriers per se was not significantly associated with PA , while functional limitations explained @number@ % of the variance of PA.
The number of excess deaths attributable to AD dementia in the United States was then estimated.
The number of female urologists has grown almost a 1000-fold and represents a growing and younger cohort of the workforce.
The number of fibroblasts and lymphocytes in glandular stroma increased with age.
The number of folds decreases with age.
The number of fractions per linac patient declined by @percent@ annually ( P < 0.0001 ) .
The number of free , unbound and thus available muscarinic acetylcholine receptors ( mAChRs ) is highest when ACh release is lowest.
The number of GFP positive cells counted by flow cytometry provides quantitative measure of NHEJ or HR efficiency.
The number of globally sclerotic glomeruli was averaged across two biopsy sections.
The number of group dental practices increased and the number of individual practices and group practices for specialized dental care and dental centres decreased.
The number of high coherent connections ( HCC ) ( coherence > 0.6-0.8 ) was estimated among @number@ leads in each hemisphere.
The number of hip fractures is expected to increase from @number@ in @number@ to @number@ in 2035-a @number@.7-fold increase.
The number of hip fractures worldwide will approximately double by the year @number@ and more than triple by @number@
The number of hospital admissions was not different between the feeding routes.
The number of incident AD cases was @number@
The number of individuals ≥70 years with HF will increase considerably in the future.
The number of individuals suffering from diseases of the central nervous system ( CNS ) is growing with an aging population.
The number of individuals who were referred to other medical institutions was @number@ ( @percent@ ) .
The number of lacunes and microbleeds ( MBs ) were counted.
The number of lacunes was associated with memory , frontal dysfunctions , and disease severity.
The number of local letters forming the global figure was modulated in @number@ steps.
The number of lymph nodes retrieved from colorectal cancer ( CRC ) resection specimens is crucial for adequate diagnosis and therapy.
The number of lymphoid cells and fibroblasts around the large excretory ducts was found to increase with age.
The number of macrophages was compared between patients with DC and controls in CD68 immunostained specimens.
The number of male cancer cases will increase by @percent@ , from @number@ in 2005-2009 to 25910 / year in 2015-2019.
The number of male nonagenarians increased more rapidly than female nonagenarians.
The number of male patients was still more than that of female patients , but more old aging patients were found.
The number of medications used per participant correlated significantly and positively ( @number@ P = @number@ ) with GFI score.
The number of metabolic diseases also correlated with incremental risks of CAVD ; presence of one abnormality approximately increases the risk approximately @percent@.
The number of midlife and older women with HIV / AIDS is high and increasing , especially among women of color.
The number of movements included in each category was significantly higher in patients than in controls.
The number of near-falls during the past year was self-reported using the Elderly Falls Screening Test.
The number of neurons in females reached @number@ million , being no more than @number@ million in males , a difference of @percent@.
The number of nighttime VMS correlated directly with the degree of sleep disturbance.
The number of obese older adults is on the rise , although we lack a proper definition of obesity in this age group.
The number of observed pathologies correlated with AD-neuropathologic change ( p < @number@ ) .
The number of older HIV-infected people is growing due to increasing life expectancies resulting from the use of antiretroviral therapy ( ART ) .
The number of older people who continue to drive is constantly increasing.
The number of older victims of domestic violence is expected to increase drastically in Asia as many countries are experiencing rapid population aging.
The number of old people is growing around the world.
The number of oligodendrocytes in the corpus callosum is established in childhood and remains stable after that.
The number of organs with Lynch syndrome-associated cancer was significantly lower with suspected familial colorectal cancer type X than with Lynch syndrome.
The number of palliative care domains addressed in the care plan increased ( @number@ vs @number@ P < @number@ ) .
The number of participants included in the analysis at baseline in @number@ was @number@ of whom @number@ were also included in the follow-up in @number@
The number of participants ranged from @number@ to @number@
The number of parvalbumin expressing interneuron in hippocampal CA1 subregion was also increased in BRINP1-KO mice.
The number of patients on antithrombotic treatment due to atrial fibrillation and venous thromboembolism is increasing fast due to an aging population.
The number of patients suffering from joint pain and progressive disability is growing , especially in economically developed countries.
The number of patients to be recruited for each group had to be at least @number@ subjects.
The number of patients with AD , the most common cause of disability in the elderly , is set to rise dramatically.
The number of patients with PML increased after the pandemic of acquired immunodeficiency syndrome.
The number of PCNA + fibroblasts in dermis showing their proliferative activity was decreased with the progression of age.
The number of people diagnosed with chronic inflammatory diseases has increased noteworthy in the last @number@ years.
The number of people living with COPD has increased substantially between @number@ and @number@
The number of people with dementia internationally is increasing.
The number of people with end stage kidney failure is increasing worldwide , mainly due to aging of the population.
The number of persons per age group ranged from @number@ to @number@ million.
The number of plasma cells was increased with age in the stroma of the glands of the upper part of the esophagus.
The number of pregnancies as well as live births was lower in women with AITD ( p < @number@ ) .
The number of pregnancies was statistically lower in the III age group compared to groups I and II.
The number of previous hospitalizations was strongly associated with poor overall functioning ( F = @number@ p = @number@ ) .
The number of procedures on patients over @number@ years of age increased significantly whereas the mortality dropped.
The number of PTA procedures remarkably increased , but the 2-year failure rate of PTAs reduced from @number@ to @number@
The number of PT was significantly correlated to HAZ and BMI-z-score.
The number of QT-prolonging drugs had a stronger influence on the risk of long QT syndrome in men than in women.
The number of redistributed tasks after the intervention was especially substantial among the dental students , although the amount of change per task was minimal.
The number of reports stating that depression is a risk factor for dementia has recently been increasing.
The number of research publications on cellular senescence last year alone is more than the number of publications in the decade in 1990s.
The number of residents showed a statistically significant relationship.
The number of retired people in Europe has increased significantly in recent decades.
The number of RGCs was counted in both the retinal sections and the flat-mount retinas after retrograde labeling.
The number of rural urologists and the number of international medical graduates have continued to decline since @number@
The number of secretory and ciliated cells from both tubal fimbria and ampulla segments was counted by microscopy and immunohistochemical staining methods.
The number of self-reported mobility limitations was computed based on an eight-item list of mobility tasks presented to the participants in @number@ @number@ and @number@
The number of sessions ranged from one to five , with weekly intervals , and timing of sample collection ranged from @number@ to @number@ days.
The number of studies related to miR-21 on hypertension is limited.
The number of subjects per group was between @number@ and @number@
The number of suicidal subjects ranged from @number@ to @number@ ( mean age = 66.8 to @number@ years old , 0-85% women ) .
The number of surgeries for colorectal cancer in elderly patients is increasing in correspondence to Japan's aging society.
The number of teeth was associated with the volume and shape of lips and with jaw mobility.
The number of theses defended in the 2000-s has increased significantly compared to the second half of 1990-s.
The number of total joint replacements , for example , is two times more than it was @number@ years ago.
The number of training programs also varies widely , with some countries having no indigenous programs.
The number of transfused RBC units was an independent risk factor for 90-day mortality.
The number of U.S. adults with VTE is projected to more than double from @number@ million in @number@ to @number@ million in @number@
The number of visits of working generations ( from @number@ to @number@ years old ) and men increased after @time@ . and on weekends.
The number of visits on Mondays was the highest in a week and the most frequent visiting time was between @number@ and @time@ .
The number of visits was projected to the @number@ population based on changes in population demographics predicted by the US Census Bureau.
The number of years separating date of discharge and testing was @number@ and @number@ for the TBI and non-TBI groups , respectively.
The number of zones showing basement membrane re-duplication was indeed strikingly reduced on C-xyloside-treated skin.
The @number@'-overhangs were analyzed in blood samples from @number@ individuals aged 91-106 years and @number@ individuals ranging from @number@ months to @number@ years.
The @number@ papers adopt a range of methodologies , from an experimental session to short- and longer-term longitudinal observational studies.
The @number@ participants were enrolled at the Cooper Institute , Stanford University , University of Pittsburgh , and Wake Forest University.
The @number@ patients ( mean age , @number@ ± @time@ ) were hospitalized for a mean of @time@ ± @time@ .
The @number@ patients were divided into severe hypoalbuminemia and non-severe hypoalbuminemia groups.
The @number@ patients who had subsequent additional treatments had three documented AEs ( @percent@ ) .
The @number@ release of arrayMap contains more than @number@ genomic array data sets , representing about @number@ tumor diagnoses.
The @number@ remaining miRNAs showed area under the curve values between @number@ and @number@
The @number@ remaining patients proceeded to undergo surgery.
The @number@ Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means.
The @number@ slice of @number@ MRIs used in this study included @number@ AD patients , @number@ MCI patients , and @number@ HC individuals.
The numbers of CD45-positive cells and mast cells are gradually increased with aging.
The numbers of circulating IFN-γ-secreting VZV-specific CD4 ( + ) T cells are significantly decreased in old subjects.
The numbers of Hispanic and African American older adults in the United States are expected to increase by @percent@ and more than @percent@ , respectively.
The numbers of non-typhoidal ( NT ) Salmonella-related hospitalizations from the Canadian Hospitalization Morbidity Database were analysed for a period of @number@ years for seniors.
The @number@ studies were classified as Level I and II evidence.
The @number@ Targeted point mutagenesis through homologous recombination has been widely used in genetic studies and holds considerable promise for repairing disease-causing mutations in patients.
The @number@ twins were comprised of @number@ MZ pairs , @number@ MZ singletons , @number@ DZ pairs and @number@ unpaired twins.
The @number@ U collagenase significantly increased MLS to @number@.5-3.0 times greater than the @number@ U did at all post-intracerebral hemorrhage ( ICH ) time points.
The @number@ WHO / FAO recommended nutrient intakes were used as the standard for adequate nutrient consumption.
The @number@ women with abdominal obesity were conventionally divided into @number@ groups : @number@ ) @number@ with PCOS and @number@ ) @number@ without this condition.
The @number@ worse complications in this series were migration of the product above the medial canthal tendon in @number@ patient and overcorrection in another patient.
The numerical density of completely sclerotic and other glomeruli was measured , and the resulting percentages were obtained from this parameter.
The numerical implementation is validated on a unit sphere using spherical harmonics.
The numerical results and hydrodynamic tests show the feasibility of the device to be adopted as a transcatheter valve implant for treating mitral regurgitation.
The nurse population is growing old in most occidental countries.
The nurses were able to create a good atmosphere and spread joy in the center together with the volunteers.
The Nursing Education Exchange ( NEXus ) is a viable solution to help meet that challenge.
Then , using activity analysis , we explored the typical contexts , demands and potential meanings of activities ( main dimension ) .
Then , using an functional magnetic resonance imaging adaptation paradigm , we measured category selectivity and individual-level adaptation for faces and houses in each ROI.
The nutritional assessment , however , must be framed in a larger comprehensive geriatric assessment addressing several functional domains.
The nutritional benefits of fish and seafood are also due to the content of high-quality protein , vitamins , as well as other essential nutrients.
The nutritional content was based on previous nutrition studies and a lifestyle education package on healthy aging , which contains four modules.
The nutritional needs in different age and disability groups should be considered.
The nutritional screening was performed using the Mini Nutritional Assessment ( MNA ) test.
The nutritional status and food intake of older individuals should be assessed regularly.
The nutritional status has been added to these factors as contributing to cognitive function decline when presenting in COPD.
The nutritional status of patients with dementia is more impaired than that of healthy patients.
The nutritional status was evaluated using the Mini Nutritional Assessment test.
The nutrition and memory in the homebound elderly study ( NAME ) excluded cases clinically diagnosed as having dementia.
Then we analyzed the NIH-CPSI scores , duration of symptoms and white blood cell count in the expressed prostate secretion ( ESP ) .
Then , we analyzed the relationship between the T1ρ and T2 values and the degree of patella cartilage degeneration.
Then we applied this battery to assess AD patients to appreciate the feasibility of this tool for this population.
Then , we apply sensitive measures of topology to the dynamic BNs to study cellular changes with age.
Then , we carry out a study to determine whether the data collected by MotorBrain can be meaningful for describing aging in human motor performance.
Then we collected primary skin fibroblast cells from a β-thalassemia patient with HBB @number@ ( A > G ) homozygous mutation.
Then we comparatively studied their endothelial differentiation capabilities and paracrine actions side by side in vitro.
Then we constructed LV twist-displacement loop and compared the characteristic of them among different groups.
Then , we discussed efforts on cell transplantation in animal models and PD patients , highlighting the immune response and the immunomodulatory treatment strategies performed.
Then , we discuss NGS technology in the context of retinal disease and develop a vision for therapies based on network biology.
Then we discuss the recent advances using genomic technology to better understand biological mechanisms driving this association.
Then we employed logistic regression models with mental health outcomes as the dependent variables.
Then we establish intersubject cortical correspondences by groupwise registration of the within-subject mean cortical folding geometries of all infants.
Then , we estimate how many baby boomers are vulnerable and to what extent.
Then , we further explored the underlying signaling pathways involved in the processes.
Then , we identified potential therapeutic conflicts and classified them as either major or minor conflicts according to their clinical significance.
Then we introduce a recently established technique for eliciting swallowing using electrical stimulation in humans and our ongoing studies using this technique.
Then , we made estimation for the location of the epigastric region using the distances between these landmarks.
Then we performed 3-SNP sliding window haplotype analyses , correcting all analyses for multiple testing.
Then we reported the assessment outcomes with respect to the rates , severity , and correlates of depressive symptoms.
Then , we tested participants ' learning using from both route and survey perspectives.
Then we used a longitudinal model to predict postoperative recovery overall , adjusting for comorbidity.
Then , we will consider how to leverage this data platform to accelerate risk factor identification and pathogenesis study with its data analytics capability.
The NYC sample spent a longer proportion of time in sedentary behavior and light activities , but more time in MVPA than the NHANES sample.
The O3 group presented a lower prevalence of BTP in comparison with other groups.
The OABSS includes scores for daytime frequency , nighttime frequency , urgency , and urgency incontinence.
The obese drank more beverages ( P < @number@ ) .
The obese participants also exhibited blunted substrate oxidation upon insulin stimulation.
The objective improvement in static rhytides ( 43%-56% ) has not previously been demonstrated.
The objective is to discover predictive markers of response to adapt the treatment at diagnosis.
The objective is to estimate average global and regional percentage brain volume loss per year ( BVL / year ) of the physiologically ageing brain.
The objective is to initiate a unified approach for monitoring progress in improving population health outcomes.
The objective is to inquire which personal network characteristics are the best predictors of mortality risk after adjustment for mental , cognitive and physical health.
The objective method was the result of the urine excretion of hypertensive persons older than @number@ years during @number@ hours.
The objective of APPLES was to compare comorbidities and risk factors in HIV-positive older GBM with an appropriate control group of HIV-negative GBM.
The objective of further subtyping is to delineate subgroups that are more clinically homogeneous.
The objective of our study was to determine validity and reliability of the LLAC measure.
The objective of our study was to explore the association between urinary levels of nine phthalate metabolites and the use of personal care products.
The objective of the current analysis is to evaluate the performance of a body-weight-dependent allometric exponent ( BDE ) model of remifentanil.
The objective of the present article is to clarify the various uncertainties relating to the use of antioxidant substances in dermatology.
The objective of the present paper is to describe other aspects of nutrition and their association with skeletal muscle mass.
The objective of the present study was the comparative analysis of acoustic parameters of the voice in the subjects of different age groups.
The objective of the present study was to analyze the cognitive function changes of two different samples , born > @number@ years apart.
The objective of the present study was to assess the relative validity of the NANA method for dietary assessment in older adults.
The objective of the present study was to determine predictive factors for hospitalizations in people with dementia.
The objective of the present study was to identify general neural correlates underlying age-related behavioral slowing and the reduction in motor task accuracy.
The objective of the present study was to investigate the effects of physical health on neuropsychological test norms.
The objective of the study was to assess anti-Müllerian hormone's ( AMH ) role in predicting spontaneous onset of pregnancy.
The objective of the study was to characterize the single-photon photobleaching action spectrum of the aged human lens in vitro.
The objective of the study was to evaluate the accuracy of retrospective recall of body weight in old age and factors that might predict accuracy.
The objective of the study was to evaluate the prevalence of thyroid hormone modifications in elderly frail subjects and its relationship with frailty.
The objective of the study was to examine the association between serum uric acid and lumbar spine bone mineral density ( BMD ) .
The objective of the study was to investigate how elderly suicide cases had perceived the health service and what characterised their contact with it.
The objective of the study was to investigate the association of 25OHD with metabolic syndrome in a population at increased risk for diabetes.
The objective of the study was to investigate the effect of RF treatments on body sculpting , as assessed by objective volumetric assessments.
The objective of the study was to investigate whether patients with post-stroke depression or DES have increased rates of stroke recurrence.
The objective of the study was to measure the costs of implementing the EnhanceFitness program to elderly residents of South Florida.
The objective of this analysis was to review the efficacy and tolerability of allopurinol up-titration in achieving the EULAR target levels.
The objective of this article is to identify a method to assess older adult cancer survivors to be used in tailoring survivorship care.
The objective of this article is to review the current and emerging treatments of CKD prior to dialysis in the elderly.
The objective of this article is to understand the concept , causes and measurement of medication errors in elderly.
The objective of this article was to determine not only CML content but also that of 5-hydroxymethylfurfural ( HMF ) in raw and cooked butters.
The objective of this article was to report on efforts in surveillance of health conditions and behaviors in underserved rural Dominican communities.
The objective of this country-based study was to identify the characteristics and mortality factors for AKI in different age groups in China.
The objective of this cross-sectional hospital-based study was to determine whether vitamin D insufficiency was associated with subjective cognitive complaint amongst geriatric patients.
The objective of this meta-analysis is to evaluate the effectiveness of combining acupuncture with herbal medicine to treat AD.
The objective of this narrative review is to discuss several promising developments in the field of gait and balance treatment.
The objective of this paper is twofold.
The objective of this report was to characterize sex differences in aging trends of pulse pressure within unindustrialized populations.
The objective of this retrospective study was to identify factors affecting curve flexibility in patients with skeletally immature and mature idiopathic scoliosis.
The objective of this review is to identify micronutrient deficits in the Middle East and to consider current and new approaches to address this problem.
The objective of this study is to determine if educational attainment is correlated with cognitive decline , brain lesion volume , and total brain atrophy.
The objective of this study is to determine the current distribution of clinical phenotypes and to estimate future trends of ALS incidence in Western societies.
The objective of this study is to determine the relationship between common dementia-associated pathologies and mid- to late-life NSAID exposure.
The objective of this study is to determine which operationalization of the MCI criteria is most accurate at predicting dementia.
The objective of this study is to examine the prevalence and factors associated with frailty in Peruvian Navy Veteran's older adults and family members.
The objective of this study is to explore family caregiver accounts of their experiences within the health care system and with individual providers.
The objective of this study is to identify the relationship between physical exercise and the feelings of well-being of the retired elderly.
The objective of this study is to physically and chemically characterize the Pb-rich particles emitted at different workplaces in a lead recycling plant.
The objective of this study is to reflect on care for people with terminal illnesses in primary health care.
The objective of this study is to use this imaging modality to monitor early effects of the home-use NAFT on collagen networks.
The objective of this study , therefore , was to estimate the economic burden of family caregiving for the elderly in southern Ghana.
The objective of this study was to analyze FoxO transcription factors in normal , aging and OA cartilage.
The objective of this study was to assess cognitive impairment and related risk factors in Chinese PD patients.
The objective of this study was to assess how agitation is managed in current practice on an ABI rehabilitation unit.
The objective of this study was to assess relationships between age and sex with FMD across childhood and adolescence.
The objective of this study was to assess the association between melanocortin-1 receptor ( MC1R ) variants and the severity of facial skin photoaging.
The objective of this study was to assess the capability of the method.
The objective of this study was to assess the risk of falls in the elderly.
The objective of this study was to assess the validity and reliability of EQ-5D in older adults with and without dementia in Mexico City.
The objective of this study was to characterize clinical efficacy using this technology to treat photodamaged skin in human subjects.
The objective of this study was to characterize psychiatric comorbidities in subjects with fragile X syndrome at different ages.
The objective of this study was to characterize the clinical phenotype of Ashkenazi Jewish ( AJ ) PD carriers of the LRRK2 G2019S mutation.
The objective of this study was to compare caveolin-3 expression in myasthenia gravis ( MG ) and control muscles.
The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls.
The objective of this study was to compare the cognitive , behavioural , and neuropsychiatric symptoms in biomarker-confirmed AD , DLB , and FTD patients.
The objective of this study was to compare the efficacy and safety of ASA in patients under and over @number@ years old.
The objective of this study was to confirm the relationship between socio-ecological factors and OLE in Europe.
The objective of this study was to determine abnormalities in plasma biomarkers of coagulation and fibrinolysis in FAP.
The objective of this study was to determine the association between polypharmacy and dementia through multiple statistical approaches.
The objective of this study was to determine the association between pre-lung cancer diagnosis HRQOL and OS.
The objective of this study was to determine the effects of age on cognitive function postbariatric surgery.
The objective of this study was to determine the prevalence and the correlates of loneliness among a community-dwelling older Mexican American population.
The objective of this study was to determine the prevalence , species and subtypes of Cryptosporidium infecting yaks in the Qinghai Province of Northwestern China.
The objective of this study was to determine whether activation of autophagy protects against mitochondrial dysfunction in human chondrocytes.
The objective of this study was to determine whether an infection-related hospitalization increased the short-term risk of a cardiovascular event in older patients on dialysis.
The objective of this study was to develop a low-cost in vitro model of glycated gelatine as an alternative to the glycated collagen model.
The objective of this study was to elucidate the prognostic differences between elderly and young patients who undergo liver resection.
The objective of this study was to estimate the cost-effectiveness of complying with HCC screening guidelines.
The objective of this study was to evaluate a new commercially available fully automatic software for MR imaging of brain volume assessment.
The objective of this study was to evaluate association with and predictive capacity of self-perceived risk of falling in recurrent falls.
The objective of this study was to evaluate attitudes towards aging of children living with elderly individuals with and without cognitive changes.
The objective of this study was to evaluate cardiac autonomic control and muscle vasodilation response during isometric exercise in sedentary and physically active older adults.
The objective of this study was to evaluate characteristics that discriminate prolactinoma from non-functioning pituitary macroadenoma with hyperprolactinemia.
The objective of this study was to evaluate IL-6-independent association of serum neopterin levels with prevalent frailty.
The objective of this study was to evaluate longitudinal , bi-directional associations between SRH and PPF.
The objective of this study was to evaluate soft-tissue histology of the columella and discuss findings that are pertinent to clinical rhinoplasty.
The objective of this study was to evaluate the effect of age on the GST in participants without vestibular disease.
The objective of this study was to evaluate the effect of cholecalciferol administration on serum 25OH vitamin D levels in HIV-infected patients.
The objective of this study was to evaluate the validity , acceptability , and reliability of using a VRHMD to assess balance in older adults.
The objective of this study was to evaluate whether heterozygous TREM2 genetic variations might be associated to the risk of FTD.
The objective of this study was to evaluate whether it can contribute to LV diastolic dysfunction in healthy subjects.
The objective of this study was to examine caregivers ' coping styles and the relationship with reported levels of burden and depression.
The objective of this study was to examine the age-related trajectories of physical functioning among those in full-time work and retirement.
The objective of this study was to examine the association of telomere length with coronary artery calcification in middle aged adults.
The objective of this study was to examine the effects of zinc deficiency on cellular immune activation and epigenetic mechanisms that promote inflammation.
The objective of this study was to examine the incidence of sarcopenia and associated factors over a 1-year period in an elderly Chinese suburban population.
The objective of this study was to examine the prevalence and characteristics of adult psychotropic medication use in São Paulo , Brazil.
The objective of this study was to examine the prevalence of MCCs from @number@ to @number@ in Taiwan.
The objective of this study was to examine the relationships between executive functions , physical fitness and mobility in well-functioning older adults.
The objective of this study was to examine the scope , resource requirements , partnerships , successes and challenges among selected Ontario CIs.
The objective of this study was to examine whether reduced inflammation is a possible mechanism for postoperative cognitive improvement in bariatric surgery patients.
The objective of this study was to examine why and how families and older adults utilize adult day services.
The objective of this study was to garner a clearer understanding of factors that influence physicians to pursue careers in neurosurgery and neurology in China.
The objective of this study was to identify and evaluate leukocyte DNA methylation patterns as a potential biomarker for early detection of CRC.
The objective of this study was to identify effective interventions that improve long-term PF in ICU survivors.
The objective of this study was to identify predictors of cognitive performance among adults with HIV.
The objective of this study was to identify the social representations of the elderly regarding active aging.
The objective of this study was to identify whether dual tasking impacts gait in healthy adults when speed is constant.
The objective of this study was to investigate anti-dementia drug use and its associations with NPS.
The objective of this study was to investigate how age affects arm reactions generated in response to unexpected slips.
The objective of this study was to investigate innate immune function in relation to long-term survival in the oldest old.
The objective of this study was to investigate subjectively and objectively the efficacy of a single fractional NIMNRF treatment.
The objective of this study was to investigate the association between benzodiazepine use and sleep quality in residents of RACFs.
The objective of this study was to investigate the association of serum potassium and the risk of atrial fibrillation in a population based setting.
The objective of this study was to investigate the frequency at which c-spine fractures were unassociated with neck pain in an aging population.
The objective of this study was to investigate the influence of schizophrenia and aging on performance in the CDT.
The objective of this study was to investigate the relationship between RBCLS and inflammatory biomarkers in chronic HD patients.
The objective of this study was to investigate whether adiponectin plays a role in modulating the bioavailability of circulating EPCs and endothelial repair.
The objective of this study was to longitudinally assess hormonal and tissue responses after RYGB.
The objective of this study was to measure regional mechanical properties of mouse aortic valve tissue using a modified micropipette aspiration technique.
The objective of this study was to pool dual-energy X-ray absorptiometry ( DXA ) body composition reference data from population-based Swedish cohorts.
The objective of this study was to quantify the bone mineral density of the coracoid process in different age groups.
The objective of this study was to understand the factors ( clinical , echocardiographic and biochemical ) that specifically influence plasma CTproET-1 in healthy subjects.
The objective of this study was to validate the diagnostic accuracy of AD-CSF-Index in our local Chinese patients with AD compared to nondemented controls.
The objective of this systematic literature review was to synthesize the available evidence on amount of SB reported by and measured in older adults.
The objective of this systematic review is to evaluate whether Internet mediated lifestyle interventions can successfully change lifestyle in people aged @number@ and older.
The objective of this systematic review was to evaluate current evidence for the efficacy of Ginkgo biloba extract EGb 761 ( ® ) in dementia.
The objective of this systematic review was to evaluate the efficiency of probiotics in treating constipation in elderly people.
The objective of this work is to determine the prevalence of FI and associated factors in institutionalized elderly.
The objective of this work was to analyze the anatomic feasibility of an epiploic BF and to determine its limits.
The objective of this work was to examine the temporal formation and progression of carotid atherosclerotic plaques in relation to telomere dynamics.
The objectives of this study are to assess mortality and calculate survival for the overall study population and within ethnicity.
The objectives of this study were to establish prediction equations for healthy Malagasy adults , and then compare Malagasy measurements with published prediction equations.
The objectives of this study were to examine cross-sectional and longitudinal associations between anemia and frailty in older Australian men.
The objectives of this study were to investigate associations between shape , age , and number of offspring in both men and women from Thailand.
The objectives were to assess and evaluate the quality of measurement properties of available clinical skin ageing scales.
The objectives were to develop a multimorbidity frailty index using Taiwan's claim database , and to understand its ability to predict adverse event.
The objectives were to involve HCWs in the creation of \ "safety zones \ " , and to give personal satisfaction.
The objective was analyze the differences of nurse consultation utilization in primary care.
The objective was to analyze primary and secondary interventions carried out in individuals diagnosed with femur fragility fracture at Teruel in @number@
The objective was to assess the drugs in the program considered to be inappropriate for the elderly.
The objective was to assess the severity of illness upon admission in relation to age and gender , in a single-center , prospective observational study.
The objective was to compare the contribution of changes in modifiable risk factors versus aging to the development of high 10-year predicted ASCVD risk.
The objective was to determine NMSs in untreated de novo PD patients.
The objective was to evaluate the psychometric properties of the Satisfaction with Life Scale ( SWLS ) in a representative sample of Mexican adults.
The objective was to examine patient and surrogate reports of ACP engagement and associations with surrogate knowledge of goals.
The objective was to examine relationships between cardiovascular and pulmonary health , and cognitive function in African American men.
The objective was to examine the effects of dark chocolate / cocoa product consumption on the lipid profile using published trials.
The objective was to examine the secretomes and chemoattractive properties of preadipocytes from visceral and subcutaneous WAT.
The Objective was to explore nursing students ' views on ageing and older adults before and after a gerontology course held abroad.
The objective was to identify common staff responses to R-REM.
The objective was to identify early determinants of incident undernutrition in a prospective population-based study.
The objective was to identify predictors of poor health outcome at @number@ years of follow-up in the Multi-Ethnic Study of Atherosclerosis ( MESA ) .
The objective was to investigate the association between family dysfunction ( FD ) and malnutrition in the elderly.
The objective was to investigate the cir-cumstances and consequences of falling and risk factors associated with limitations in performing activities after falling.
The objective was to summarize the evidence regarding the effect ( s ) of comorbidity on the outcomes of medication for an index chronic condition.
The object of this study was to assess the effectiveness of AMD documentation at a local Veterans Affairs Medical Center.
Theobromine , present in cocoa , the main LMN diet component , was analysed in parallel using SH-SY5Y and PC12 cell lines.
The observational period for each patient was > 48 months , beginning at the time sitagliptin therapy was initiated.
The observation of increased hyperphosphorylated tau levels correlating with microglial activation in opiate abusers has been interpreted as predisposition to accelerated Alzheimer disease-related changes.
The observation period of the free-living physical activity of stroke survivors was significantly less than that of the healthy controls.
The observations are useful to evaluate the best preventive and treatment options on the basis of the most recent pathophysiological considerations.
The observations could be explained by neuromuscular performance and change of MU activation patterns may result from age-related sarcopenia.
The observed absence of such an association in the offspring suggests an altered regulation of mitochondrial biogenesis in the members of long-lived families.
The observed adverse association between the consumption of dark fish and AF merits further investigation.
The observed age-related changes of pSTS intrinsic functional connectivity ( iFC ) suggest that no single developmental pattern characterizes ASD.
The observed cellular phenotypes are in keeping with data from in vitro and in vivo knockdown studies performed in human cells and mice , respectively.
The observed changes are complex and multivariate in nature.
The observed changes in six of these eight signs , in majority related to pigmentation , appeared efficiently alleviated in the photo-protected group.
The observed changes suggest a decreased activity of the one carbon metabolism in pept-1 ( lg601 ) mutants.
The observed correlation between atherosclerosis and AD pathology supports the latter.
The observed decrease of Yin deficiency related symptoms is in agreement with the use of R6 in Chinese medicine to nourish Yin.
The observed dietary intake was related to Recommended intake and Lower intake level.
The observed differences challenge stereotypes and prejudices relating to negative aging process.
The observed effects show promise for potential factors to reduce cortical atrophy in normal aging.
The observed high mean WL in worksites and videoconference-delivered programs broadens options for scalable WL program implementation.
The observed improvement is significantly greater than that seen with the classical training program.
The observed increase in the hosts ' lifespan is shown to confer a significant selective advantage for a pathogen in some parasitic systems.
The observed interaction effect between bone lead and the Bsm1 genotype persists over time during the follow-up.
The observed inverted relations support a link between dopamine and DLPFC efficiency.
The observed mortality rates were lower compared to earlier studies conducted in younger patient groups.
The observed negative correlations between callosal thickness and intelligence in children and adolescents contrast with the positive correlations typically reported in adult samples.
The observed neural characteristics of 5-repeat allele carriers may lead to an increased risk of ADHD and behavioral deficits.
The observed pattern of results suggests that microstructural white matter integrity may be especially important to perceptual speed among very old adults.
The observed patterns support the existence of adverse effects of smoking on CRC prognosis among nonmetastatic CRC patients.
The observed probabilities illustrated that approximately @number@ in @number@ men and women of middle age will suffer from a stroke in their remaining lifetime.
The observed relation between scanning patterns and executive function supports the hypothesis that frontal-lobe changes with age may underlie some changes in emotion recognition.
The observed systematic down-regulation of several mitochondrial respiratory chain components implies compromised function in oxidative phosphorylation and thus in the production of chemical energy.
The observed telomere loss in newborns by prenatal air pollution exposure indicates less buffer for postnatal influences of factors decreasing telomere length during life.
The observed trajectory of [ 18F ] -FDG alterations deviated from our proposed hypothesis of gradual decreases with worsening amyloidosis.
The observed U-shaped association between obesity status and CES-D score was tested by regressing CES-D score on linear and quadratic terms of BMI scores.
The observed VaD effect is probably linked to cardiovascular risk comorbidities : hypertension , stroke and hyperlipidemia.
The observers judged the extent of fronto-parallel and in-depth spatial intervals at a variety of viewing distances from 50cm to @number@.3cm.
The observer's task was to indicate whether a stereoscopic cartoon character was nearer or farther away than a zero-disparity reference frame.
The obstacle increased the spatial-temporal variability ( step-to-step and walking variability ) during the approach phase to the obstacle.
The obstacles and prospects in this field will also be discussed.
The obstacle was positioned 4m from to the start position.
The obtained classifier was significantly above the chance level ( @percent@ ) for detecting AD already @number@ years before conversion from MCI.
The obtained data indicate that the aged and cataractous human lenses are more vulnerable to UV-A light than the middle-aged lenses.
The obtained hydrophobic GCIS / ZnS BQDs were surface engineered into aqueous phase with PEGylated dextran-stearyl acid polymeric lipid vesicles ( PEG-DS PLVs ) .
The obtained lice were used for in vitro tests.
The obtained measurements were : greater horizontal diameter ( HD ) , greater vertical diameter ( VD ) , orbital perimeter and orbital base area.
The obtained pulp-tooth volume ratios were the strongest related to age on incisors.
The obtained results accentuate phenolic acids as the more specific antioxidants compared to ascorbic acid and Trolox.
The obtained results do not support a causal relation between the supraphysiological hormone levels stimulation and worsening of clinical and dermoscopical features of moles.
The obtained results showed that physically active elderly people have shortened P300 latency and higher amplitude.
The obtained results were compared to those of monolithic zirconia ( 3Y-TZP ) femoral heads.
The obtained results were compared with the results of adult healthy subjects , forming a control group.
The obtained signal of COP was then analyzed in both time and frequency domains in order to perform a thorough analysis of the signal.
The obvious source for the chronic inflammatory stimulus in the prostate is the documented dramatically altered lower female genital microbiota associated with the menopause.
The OC-1 and OC-2 courses exhibit similar clinical results.
The occlusal surfaces of @number@ molars were grinded to obtain flat enamel surfaces.
The occupancy rate displays positive associations among contextual factors.
The occurrence and progression of diseases are strongly associated with a combination of genetic , lifestyle , and environmental factors.
The occurrence of ACS was recorded among @number@ patients ( @percent@ ) and ACS-related death among @number@ patients ( @percent@ ) .
The occurrence of arrhythmias was associated with higher mortality ( excluding cardiac surgical death , @percent@ vs @percent@ , P = @number@ ) .
The occurrence of chronic diseases such as neurological , metabolic and cardiovascular degenerative disorders increases with age.
The occurrence of delirium may increase the related physical and psychological risks , delay the length of hospital stays , and even lead to death.
The occurrence of de novo mutations in ALS genes might be an explanation for sALS , but reduced penetrance could be an alternative theory.
The occurrence of depression in patients with coronary heart disease ( CHD ) substantially increases the likelihood of a poorer cardiovascular prognosis.
The occurrence of diabetes-related complications and all-cause mortality were the primary outcomes of this study.
The occurrence of falls over the follow-up period of @number@ months was recorded.
The occurrence of falls was also observed.
The occurrence of falls was related to BMI , gender and age.
The occurrence of hyperglycemia was independent of sex , but it occurred mostly in children under @number@ years old.
The occurrence of myopathy , rhabdomyolysis and cognitive impairment was largely unreported in the included trials.
The occurrence of nonneoplastic lesions in the kidneys of BN / aW mice was increased ( P < @number@ ) .
The occurrence of pulmonary fibrosis in numerous individuals from the same family suggests a genetic cause for the disease.
The occurrence of several geriatric conditions may influence the efficacy and limit the use of drugs prescribed to treat chronic conditions.
The occurrence of SN , aging and disc location were positively correlated with lumbar disc degeneration grade.
The occurrence of spontaneous recognition is discussed in relation to ability to constrain retrieval to goal-relevant information.
The occurrence of stroke increases with age , but anyone at any age can suffer a stroke.
The occurrence of three and four risk factors was more prevalent in Mexico , the Russia Federation and South Africa.
The occurrence of uterine neoplasms was higher in DBA / W and 129S1 / SvW mice.
The occurrence , patient characteristics and outcomes of sepsis hospitalizations during the years @number@ and @number@ were estimated and compared with Norwegian population data.
The occurrence rate of such saccades was similar in the young and the elderly subjects.
The occurrence rate was @percent@.
The occurrences of significant change in laminar depth and neuroretinal parameters were compared with survival models.
The oceans encompass a wide range of habitats and environmental conditions , which host a huge microbial biodiversity.
The Octopus G1 program showed @percent@ sensitivity and @percent@ specificity to detect CVFD in eyes where the HFA 10-2 test revealed a CVFD.
The ocular spherical aberration ( @number@ μm / year ) and horizontal coma ( @number@ μm / year ) increased moderately with age.
The oculocutaneous albinism II ( Oca2 ) gene has previously been identified as the p gene.
The oculomotor system facilitates obtaining accurate information from the visual world.
The ODA analyses shows that Hispanics on average have higher levels of declining health and increased depression attributable to the discrimination factor.
The odds associated with 1°C increase in central temperature was @number@ ( @percent@ CI : @number@ @date@ ) .
The odds of absent responses were significantly higher in individuals age ⩾80 for oVEMPs , and age ⩾70 for cVEMPs.
The odds of being overweight in adulthood was @number@ times greater ( @percent@ CI : @date@ @number@ ) in overweight compared with healthy weight youth.
The odds of detectable viral load after cART initiation decreased with age ( p-trend = < @number@ ) .
The odds of DGF were almost five times higher for a combination of CX ( CT or CC ) donor genotype and TT recipient genotype.
The odds of disability in IADL and PT remained significantly higher for women compared to men after accounting for all available covariates.
The odds of experiencing caries ( DMFT , DT , FT ) increased with increase in participant's age.
The odds of exposure to polypharmacy were higher for older subjects , males and subjects living in urban areas.
The odds of heavy drinking decrease at lower levels of wealth.
The odds of in-hospital mortality decreased by @number@ for every additional FTE-RN added per patient day , even after controlling for covariates.
The odds of SI and SH were examined for groups defined by presence of PfS and social isolation.
The odds of using health care services were larger among older people with both depressive symptoms and CMI than depressive symptoms only.
The odds ratio and @percent@ Cl for associations between use of psychotropic drugs and fall are @number@ and @number@.57-2.01 , respectively.
The odds ratio for T2D ( top vs. bottom quintiles of gene score ) was @number@ ( @percent@ CI @number@ @date@ ) .
The odds ratio of decreased renal function increased as the number of components of MetS increased.
The odds ratio of lipoprotein ( a ) was @number@ on PVT and @number@ on HCC.
The odds ratios for MetS were @number@ in men and @number@ in women after adjustment for confounding variables ; both were statistically significant.
The odds ratios varied from @number@ to @number@
The ODI scores decreased significantly from @number@ ± @number@ preoperatively to @number@ ± @number@ postoperatively ( P < @number@ ) .
The official Danish population forecast 2006-2015 was applied for projecting the population composition.
The official migrant death statistics for Germany suffer from incomplete migrant population stock data due to non-registered remigration events.
The offspring of the long-lived siblings were followed from @number@ to @number@
The offspring under study carry an increased risk of AD but do not yet experience cognitive impairment.
The often required dosage of 25 ( OH ) VitD is reasonably not necessary to initiate VitD supplementation protocol in this vulnerable population.
The often subtle clinical manifestations in the frail geriatric patients may not be recognized initially , impeding timely administration of antiviral treatment.
The OG adopted a different gait pattern at the faster speeds by generating more H3 work than A2 work.
The oil from the jojoba plant is the main biological source of wax esters and has a multitude of potential applications.
The oil paint presented the highest color resistance to artificial aging regardless of drying method.
The old adults also presented a lower muscle power.
The old and more recent oral glucose-lowering agents , along with the newer types of insulin , will be discussed in this review.
The older adult and the older adult diagnosed with Parkinson's disease exhibited both tolerance and health-related improvements in physical fitness following the intervention.
The older adult group was significantly more sensitive to linear than to circular gratings in all spatial frequencies , except in the @number@ cpd frequency.
The older adult population faces unique challenges to receiving adequate nutrition.
The older adult population is growing rapidly with various comorbidities for health care providers to consider.
The older adults also modified eye movements less depending on the hand termination and accuracy requirements.
The older adults also showed higher levels of activity in the ipsilateral ventral premotor cortex.
The older adults demonstrated significantly less total sway path , but larger total sway area in single-leg stance after stepping down than the young adults.
The older adults had significantly longer reaction times and higher error rates when dual-tasking compared with single-tasking , but the younger adults did not.
The older adults had similar amounts of joint movement as the young adults during balance recovery except for the thoracic-lumbar joint.
The older adults ' performance on destination memory was significantly correlated with and predicted by their performance on cognitive theory of mind.
The older adults produced slower responses.
The older adults showed age-related deficits on all measures of bimanual motor performance.
The older AEDs have the advantages of being cheaper and being readily available in developing countries.
The older-aged have many different types of living circumstances.
The older age group had more concomitant diseases and used more drugs , which may have reduced efficacy.
The older cohort consumed significantly less ( p < @number@ ) dietary protein when compared to the young cohort.
The older cohort scored higher on Agreeableness and Conscientiousness.
The older control group had significantly greater COP area and velocity compared with younger controls for the BRU and the SOT.
The Older Drivers Project ( ODP ) of the American Medical Association has provided evidence-based training for clinicians since @number@
The older group had higher end-inspiratory lung volume compared to Y-matched%Pred FVC group during submaximal ventilations.
The older group had higher rates of confusion , organic diagnoses , but lower levels of previous psychiatric admissions.
The older group increased EELV during exercise , while EELV stayed below resting in the Y-matched%Pred FVC group.
The older group represented @percent@ of the whole studied population and @percent@ of them were dialyzed.
The older groups scored 2-3 , 2-5 , and 4-6 points better than the younger groups at @number@ @number@ and @number@ months , respectively.
The older participants had larger MEPs during saliva swallowing than the young participants ( p = @number@ d = @number@ ) .
The older participants ' judgments of surface shape were just as accurate and precise as those of the younger participants.
The older participants were at the time of injury , the greater the curvature and the more rapid decline were found in later years.
The older patient will be confident and satisfied with the caring encounter if the desired components in the nurse's approaching are exhibited.
The older patient with IBD is more susceptible to disease-related complications and also to adverse events with therapy , particularly immunosuppression.
The Older People in Acute Care Survey - United States ( OPACS-US ) is an instrument measuring hospital nurses attitudes regarding older patients.
The older people need more health and social services , and their life quality in there is getting more and more important.
The older people should often have fish because of their nutritional benefit.
The older persons demonstrate a decrease in basal level of reactance of touch areas.
The older population is currently the fastest growing age group in the United States , and this trend is expected to continue for several decades.
The older respondents tended to have a lower saliva flow and pH compared to their younger counterparts.
The older RVO group had a longer history of hypertension and less smoking history.
The \ "older seniors \ " ( 76 + ) were ambivalent towards certain wordings referring to aging.
The older Spaniards lived under Franco's political regime ( 1936-1975 ) , whereas the Americans never experienced such repression.
The older the cat , the lower was dyadic event type complexity.
The older the insured are , the larger the enrollment rates are.
The older two groups showed greater variability , with the middle elderly group being most variable.
The older woman faces a number of changes to her sexual health , wellbeing and sexuality.
The oldest group is important because they are at the highest risk for both osteoporosis-related complications and treatment-related adverse events.
The oldest participants also exhibited lower anterior and posterior tongue elevation strength relative to the middle-age group.
The oldest people carrying AG genotypes for rs7895833 have the highest SIRT1 level suggesting an association between rs7895833 SNP and lifespan longevity.
The oldest planks exhibited high As concentrations , which was related to its original treatment with high retention of CCA preservative.
The oldest quintile included @number@ patients @number@ years old and over.
The oldest seniors , on the contrary to the old ones , revealed similar level of serum antioxidant status as the young subjects.
The oldest third of the men were most affected by LOH symptoms ( p < @number@ ) .
The old showed more habituation to highly arousing negative but not positive or neutral stimuli in prefrontal cortex as compared to younger participants.
The Omaha System assessment currently consists of identifying signs / symptoms for @number@ health concepts.
The Omaha System was used as a documentation system to capture both interventions and client outcomes.
The oncoming retirement of baby boomers has governments worried.
The one-week test-retest reliability using intra-class correlation coefficients ( ICCs ) showed significant correlations except for the EB and RANDOM subscales.
The one-year mortality was @percent@.
The ongoing debate on U.S. healthcare reform fueled by increasing cost and poor access to quality healthcare is spurring interest in medical travel.
The ongoing demographic development creates distinctive challenges for the management of hospitals.
The ongoing glycation by methylglyoxal @number@ mM resulted in pronounced decrease in the GST activity.
The ongoing TACT2 trial may clarify its use in post-MI diabetic patients.
The online algorithm operating showed performance results of @percent@ specificity , @percent@ sensitivity and @percent@ accuracy.
The online survey was anonymous and carried out using a secure website.
The only approved medications for AD are symptomatic and there are no currently available disease modifying treatments.
The only available treatment for cataract is surgery.
The only condition for participation is to be a person able to hold a brush.
The only diagnostic criteria to significantly predict dementia @number@ years later was the cognitive impairment no dementia ( CIND ) -2 case definition.
The only difference was the faster recovery when the arthroscopic approach was used.
The only direct inhibitor of electromotility and the associated charge transfer is salicylate , possibly through direct interaction with an anion-binding site on prestin.
The only exception to the general improvement in sleep after retirement was related to retirement on health grounds.
The only factor associated with poor sexual function was being over @number@ years of age.
The only factor consistently associated at all ages with increased likelihood of loneliness was not being married.
The only factor related to female sexual function that was associated with the metabolic syndrome was sexual dysfunction in the woman's partner.
The only factor that negatively influences the survival rate is the 2b clinical category of acute ischemia , regardless of the age of the patient.
The only global parameter , AI , showed a high repeatability and the overall best correlations with AIX and PWV.
The only longitudinal study to examine changes in ABPV , however , found ABPV decreased over @number@ years follow-up.
The only parameter associated with PWV was preperitoneal fat tissue thickness.
The only parameter that was significantly different from the preoperative value was the steepest keratometry reading in Group @number@ patients.
The only postoperative age-related morbidity was confusion in the elderly.
The only protective factor against xerostomia identified was medications that induce hypersialorrhea OR = 0.81 , @percent@ CI ( @number@.67-0.98 ) , p = 0.03.
The only significant relationships observed were in association with weight loss ( P ≤ @number@ ) , most likely signaling incipient disease.
The only statistically significant difference between the sociodemographic characteristics of patients with or without ICDs was gender.
The only variable associated to HPV infection was the history of previous sexually transmitted disease ( OR = @number@ , P = @number@ ) .
The only variable positively associated with SA was good self-perceived health-status ( P < @number@ ) .
The only way to reduce the risk of DSWLs misuse is providing all of the necessary information by the health care professionals.
The onset and maintenance of senescence are regulated by two tumor suppressors , p53 and retinoblastoma proteins.
The onset of an age-related decline in aiming duration can be clearly located in middle adulthood.
The onset of anisometropia occurred at all ages within the studied age range , with no particular preference for any one age.
The onset of chronic disease is often the prelude to the subsequent physiological and mental twilight in the aging population of modern society.
The onset of functional disability and all-cause mortality were followed up for @number@ d ( follow-up rate = @percent@ ) .
The onset of lead lower limb movement in relation to object movement onset was quantified as a measure of motor coordination.
The onset of symptoms is insidious , but the longer the CAG expansion , the earlier their occurrence.
The onset of the decline of the teeth-mandible relationship coincides with the onset time of the adult-like pattern of mastication and speech.
The onset of the distracting speech masker triggered a prominent contingent negative variation ( CNV ) in the EEG.
The onset of the nocturnal surge was delayed by increasing BMI and advanced by increasing age.
The onset of tolerance to surgery occurred after @number@ days ( SD : @number@ ) .The transfusion rate after surgical intervention was @percent@.
The onset time , maximum level and time to reach the maximum level of sensory and motor blockade were recorded.
The onset VEP waveform produced by @number@ checks is distinguished by more prominent negative C2 and earlier C1 and C2 latencies.
The onset was acute or subacute in @number@ patients , insidious in @number@ and unclassified in @number@
The oocyte is the major determinant of embryo developmental competence in women.
The oocyte must be the locus of reproductive aging because donation of oocytes from younger to older women abrogates the effects of aging on fecundity.
The ooplasmic volume was also significantly larger in the group achieving pregnancy.
The opacity ( CR ) for enamel nor for enamel dentine complex does not change within the two age groups considered in this study.
The Open Access Series of Imaging Studies is a series of neuroimaging data sets that are publicly available for study and analysis.
The Open Door intervention offers a strategy to overcome barriers to mental health treatment engagement and to improve the odds of quality care for depression.
The opening angle caused by radial cut of arterial ring defines residual stress.
The open physis group had longer mean T2 relaxation times at the osteochondral area and articular cartilage than in the central portion.
The operational definitions utilized in the included studies identify between < 1% and > 90% of study participants as successfully aging.
The operation is easy and can reduce hospitalization days.
The ophthalmic branch of the trigeminal ganglion contains somas of neurons that innervate the cornea.
The ophthalmology technician follows a detailed protocol that collects information about the patient's eyes.
The opportunities for metal-targeted pharmacological strategies in the major NDs are briefly outlined as well.
The opportunity to choose when stop practicing facilitated motor performance and learning compared to the yoked condition.
The opposable thumb , which is critical for hand dexterity and strength , can be severely disabled by basal joint arthritis.
The opposite effect was observed when cells were transfected with shorter isoforms ( TS2 and TS3 ) .
The opposite occurred for thrombocytosis.
The opposite pattern was observed for words.
The opposite trend was present for the left PHC.
The optical intensity in RNFL was negatively correlated with age ( r = @number@ ) .
The optical intensity of RNFL decreased with age.
The optical properties of the lens are dependent upon the integrity of proteins within the fiber cells.
The optic nerve exhibits structural changes with age.
The optic nerve head in glaucoma : role of astrocytes in tissue remodeling.
The optic nerve head in glaucomatous optic neuropathy.
The optimal cardiovascular risk stratification approach in this evolving patient population remains unclear.
The optimal cut-off score for detection of AD was 19 / 20 , which gave sensitivity and specificity of @percent@ and @percent@ , respectively.
The optimal cut-off score for detection of aMCI was 22 / 23 , which yielded a sensitivity and specificity of @percent@ and @percent@ , respectively.
The optimal cut-off values for predicting hemorrhage were : R = @number@ K = @number@ MA = @number@ ANGLE = @number@
The Optimal group performed better in Processing Speed ( p = 0.016 ) and Executive Functioning ( p < 0.001 ) .
The optimal management in this population often requires complex multidisciplinary supportive care due to multiple comorbidities to optimize their cancer care.
The optimal management of SEAs in patients @number@ years of age and older remains a matter of considerable debate.
The optimal source of antioxidants seems to come from our diet , not from antioxidant supplements in pills or tablets.
The optimal subsidy on preventive expenditures is shown to depend on the combined impacts of misperception , externalities and self-selection.
The optimal surgical approach for this group of patients is still debated.
The optimized transfersomal formulation of EGCG and HA exhibited considerably higher skin permeation and deposition of EGCG than that observed with plain EGCG.
The optimized transfersomes were found to increase the cell viability and reduce the lipid peroxidation , intracellular ROS and expression of MMPs in HaCaT cells.
The optimum balance remains to be found for the design of shoes regarding at once cushioning , durability and injury prevention.
The optimum dose and frequency of pulse steroid therapy were significantly lower in elderly patients ( p = @number@ and @number@ respectively ) .
The optotype display was placed at @number@ m for NearDVA and at @number@ m for FarDVA.
The oral and craniofacial abnormalities caused dental caries , severe malocclusion , and swallowing , feeding and speech problems.
The oral health status of participants was assessed by clinical examination.
The oral nutritional supplements ( ONS ) helped participants to regain their energy and to motivate them to exercise and make changes in their diets.
The orbicularis oris muscle becomes thinner and shows a decrease of the forward curve defining the vermilion border.
The orbicularis retaining ligament arose from the inferior orbital rim and ended at the junction of palpebral and orbital portions of the orbicularis oculi muscle.
The orbicularis retaining ligament continued with the origin of the orbicularis oculi muscle and the dense muscular attachment arose from the maxilla.
The orbitofrontal cortex ( OFC ) is vulnerable to normal and pathologic aging.
The Orbscan® ( Bausch and Lomb ) procedure was used for pachymetry and keratometry.
The order in which they completed the schedules was not randomized but was accounted for in all statistical analyses.
The order of inhibition was reversed in eight subjects ( group @number@ ) .
The order of IP and TP test administrations in individual subjects was determined randomly.
The order of testing was randomized , with sessions occurring a minimum of @number@ week apart.
The order of the lists was randomized across subjects.
The ordinal levels of performance across different conditions argued against rule-complexity , as older adults showed greater deficits on less complex categories.
The ordinary ways of ' being in the every day' , such as having a routine and a familiar purposefulness , conceal being aged.
Theoretical analysis then used the ICF to reconceptualize the data using a disability lens.
Theoretical and practical implications are discussed.
Theoretical and practical implications are discussed.
Theoretical explanations for age differences focus on the allocation of attentional resources to support prospective remembering.
Theoretical explanations for negative outcomes have been developed.
Theoretical explanations state that personal networks offer indirect psychosocial and direct physiological pathways.
Theoretical health , the total absence of pathological conditions , is then a value-free scientific notion.
Theoretical implications are discussed.
Theoretical implications are discussed in this review.
Theoretical implications of these results are discussed.
Theoretically , dose selection in paediatric drug development or clinical settings can be done by using either body weight or the clearance of a drug.
Theoretically , it sheds new light on the under-researched area of control beliefs in older men.
Theoretically , multimorbidity results in an innumerable potential disease constellations.
Theoretically , our findings extend contemporary thinking on secondary control.
Theoretically these substances could be used to enhance recovery after brain injuries.
Theoretically with appropriate stimulation from the pituitary , the aging testis should be able to produce eugonadal levels of testosterone.
Theoretical models and preceding studies have described age-related alterations in neuronal activation of frontoparietal regions in a working memory ( WM ) load-dependent manner.
Theoretical predictions of magnetic force distribution within each well demonstrated that there was no magnetic field interference among magnets in adjacent wells.
The orexigenic hormone , ghrelin may moderate anxiety and stress-related eating behavior.
The OR for all-cause mortality was @number@ ( @percent@ CI @number@ @date@ ) .
The organic depressive disorders frequently co-exist : the teams dementia , anxiety , personality disorders , delusional teams.
The organisation of health and social care relies on the delegation arrangement to meet the needs of a growing number of older home-care recipients.
The organizational network changes in the human brain across the lifespan have been mapped using functional and structural connectivity data.
The organization eventually altered greatly , shifting to a more localized organization in old age.
The organization of the brain network enables its function.
The organization of these interpersonal abilities and how they change across the life span are still poorly understood.
The organization operates in long-term health-care facilities or in low-income housings and day centers.
The organized aggregation of misfolded proteins is proposed to serve several purposes collectively increasing cellular fitness and survival under proteotoxic stress.
The Orienting×Executive networks interactions was only observed after about age @number@
Theories of embodied cognition propose that perception is shaped by sensory stimuli and by the actions of the organism.
The original and best evidence for the existence of CSCs came from advances in the field of haematological malignancies.
The original categories did not provide an optimal assessment of functional incapacity.
The original cohort consisted of @number@ participants with selective service records who were living on the island of Oahu , Hawaii , in @number@
The original crude incidence rates were standardized for age and sex for comparability.
The original data set consisted of all foods reported ; each food was coded as if it was consumed individually.
The original Leuven trial demonstrated that proper implementation of glycemic control can reduce morbidity and mortality.
The original method of Morris and Temple was applied to the discovery cohort.
The original MPOD values without automated correction were used for analysis.
The original pink-eyed dilution ( p ) on chromosome @number@ is a very old spontaneous mutation in mice.
The original protein Toll in Drosophila melanogaster regulates both host defense and morphogenesis during development.
The origin of life is the result of requirement by the quasi-equilibrium hierarchical thermodynamics , in particular , the supramolecular thermodynamics.
The origin of these changes are studied using simulations and experimental measures.
The origin of the telomeric sequences co- localizing with the major rDNA sequences or scattered along the whole chromosomes is not clear.
The origin of this ovarian dysfunction is still debatable.
Theorists struggled for more than a century in efforts to develop non-programmed theories that fit observations , without obtaining a consensus supporting any non-programmed theory.
The OR of receiving IVT was @number@ ( @percent@ CI @number@.54-0.86 ) for patients with dementia.
The ORR was @percent@ overall ( n = 9 of @number@ ) .
The ORs and possible mechanisms have been discussed in this article.
Theory and past research suggests filial obligation ( FO ) may mediate the relationship between attachment and caregiver preparedness.
Theory emphasizing the inevitable decline of human capacity was gradually replaced with concepts stressing positive , multidimensional views of aging.
The oscillation of the center of pressure was assessed with a force platform.
The os pubis is one of the most widely used areas of the skeleton for age estimation.
The osteocyte network , under physiological conditions , activates osteoclastogenesis and suppresses osteoblast function enhancing bone resorption and inhibiting bone formation.
The osteogenic potential of these cells exceeds that of adipose and skin-derived stromal cells and is equivalent to bone marrow stromal cells.
The OTC-fed aged mice also exhibited hepatic steatosis and triacylglyceride accumulation.
The other aim was to explore the correlation between post-CAS hypotension within @number@ h and long-term BP reductions after CAS.
The other antioxidants such as green tea , dehydroepiandrosterone , melatonin , selenium and resveratrol , have also antiaging and anti-inflammatory effects.
The other breeds tested did not have the polymorphism.
The other case was clinically diagnosed as drug-induced hypersensitivity syndrome.
The other endoscopic findings were similar between the two groups.
The other group of patients who sustain an intracapsular fracture at the femoral neck are at increased risk of nonunion and osteonecrosis.
The other half and the surviving specimens were subjected to quasi-static loading until failure.
The other hemisphere was comprehensively dissected and frozen for molecular studies.
The other independent @number@ individuals were selected for the validation cohort.
The other @number@ factors have been less frequently evaluated , and current literature is not definitive.
The other one is local , but involves a multicomponent field of speed states.
The other outcomes were not significantly associated with frailty status.
The other parameters did not change significantly.
The other possible effects of that complex in humans are still under investigation.
The other rats were fed ad libitum.
The other reactions covered 4-18%.
The other secondary functions of melatonin came about much later in evolution.
The other sensory stimulation interventions lack evidence , and there is a strong need for further research.
The other seven cases were misdiagnosed as pneumonia and the time to accurate diagnosis was from @number@ month to @number@ months.
The others represented a control group ( C ) that did not exercise.
The other studied candidates showed significant correlations in the telomere-mitochondrial interactome but not independent from SIRT1.
The other study ( @number@ ) showed vardenafil , another formulation of PDE5i , to be protective against noise-induced hearing loss in mice and rats.
The other study ran for four months with a data collection point at the start and end of the study only.
The other two species are catabolic fragments of @date@ and @date@ which have the amino acid sequence DPEAAE as their carboxyl terminus.
The other variables investigated ( i.e. , setting and product categories ) led to no conclusive findings for the three societies.
The Ottawa Charter of Health clearly states housing as a prerequisite of health.
The outcome achieved throughout childhood remains stable during adult life as long as catastrophic events of shunt malfunction can be prevented.
The outcome had to address all-cause mortality or cardiovascular events.
The outcome in patients treated for rAAA by eEVAR or OPEN repair was investigated.
The outcome measure , maximum grip strength , was measured at each measurement point.
The outcome measurements were combined by calculating the mean difference with @percent@ confidence interval.
The outcome measures of interest were vHIT gain and velocity.
The outcome measures were a computer-based working-memory test ( 2-back ) and several standardized psychometric tests of memory and executive cognitive functions.
The outcome measures were balance as measured by any validated outcome measure.
The outcome measures were mental and physical health ( SF-12 ) and quality of life ( WHOQOL-8 ) .
The outcome measure was a summary of multidimensional domains influencing LS : health , finance , housing , neighbor relationships , and family relationships.
The outcome of AKI needing CRRT in elderly patients is known to be poor.
The outcome of cognitive impairment in Alzheimer's disease has both individual ( the patients and their families ) and socio-economic effects.
The outcome of interest was PSF ( fatigue that limits daily activities reported at baseline and 12-month follow-up ) .
The outcome of interest was the annual rate of emergency department utilization obtained from the Center for Medicare and Medicaid Services.
The outcome of interest was the first occurrence of MMD or incident MMD.
The outcome of recipients receiving kidneys from living donors has demonstrated superior graft and patient survival compared to deceased donors.
The outcome of the Chernobyl nuclear power plant ( CNPP ) accident was that a huge number of people were exposed to ionizing radiation.
The outcome of the lifelong special treatment , and the particularities of phenylketonuria in adulthood are yet to be determined.
The outcome of the study is mortality over a 2-year follow-up since the survey.
The outcome prevalence was calculated according sociodemographic , behavioral and health related variables.
The outcomes also revealed that the prevalence of suspicion for mental disorders increased noticeably with aging.
The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA ( MAFEIP ) .
The outcomes , however , of varying styles of caregiving are unknown.
The outcomes including change in overall cognitive function , memory , attention , executive function , and visual-spatial ability.
The outcomes of focus were sunscreen use , shade seeking , and use of sun protective clothing.
The outcomes of patients with a hypoenhancement area detected by MDCT have not been clear.
The outcomes of studies were categorized in the short-term and the long-term , according to the follow-up period of readmission.
The outcomes rate of cognition changes are assessed by the Montreal Cognitive Assessment scores , and rate of motor changes are assessed by UPDRS part-III.
The outcomes were compared with the previous OAMH liaison service data over the same period a year earlier.
The outcomes were obtained using administrative data from electronic medical records.
The outcomes were the 5-year mortality rate , the loss of autonomy and mental decline.
The outcome variables were HGS and FWS assessed at each survey.
The outcome variable was health-related quality of life of older adults , measured by SF-12 ( physical and mental components ) .
The outcome variable was suicidal ideation.
The outcome variable was the presence of difficulties while carrying out basic ADL after @number@ years.
The outcome was defined as having or not VE episodes during a study visit.
The outcome was disability measured with the Groningen Activity Restriction Scale.
The outcome was measured using the AOFAS Ankle-Hindfoot score and a Linear analog scale.
The outcome was pelvic girdle pain @number@ months after delivery.
The outcome was person-specific cognitive slopes ( Modified Mini-Mental State Examination ) from @number@ years of follow-up.
The outcome was the Functional Recovery Scale total score measured at four time points during a 12-month period of observation.
The outcome was the number of residents dying in nursing homes from @number@ to @number@
The outer segments of cones serve as light detectors for daylight color vision , and their dysfunction leads to human blindness conditions.
The out-of-pocket expenditures per person accounted for almost half ( @percent@ ) of their daily income.
The outpatient GEM services significantly reduced the items of oral medications and improved quality of life.
The output of naïve T lymphocytes by the thymus decreases , increasing susceptibility of aged individuals to infection and cancers.
The outputs were reviewed by an expert panel.
The overall activity score was @number@ as determined by the intraclass correlation coefficient ( ICC ) .
The overall agreement for Study @number@ was > 60% with a kappa value of @number@ ( @percent@ CI @number@.433-0.645 ) .
The overall aim was to investigate effects of a pain management intervention on nursing homes residents and to describe staffs ' experiences of the intervention.
The overall and complete response ( CR ) rates were @number@ and @percent@ , respectively.
The overall annual cancer burden predicted for 2015-19 is of @number@ new cases in Switzerland.
The overall assessment of ARTAG showed moderate agreement ( kappa @number@ @percent@ CI @number@.534-0.653 ) among raters.
The overall brain activation in the IPD group was more extended as number of voxels with respect to ESs , suggesting underlying compensatory mechanisms.
The overall cancer burden in China has been increasing during the past decades.
The overall cardiovascular risk was not increased in dizzy patients.
The overall complication rates were @percent@ in group E and @percent@ in group Y ( P = 0.427 ) .
The overall complication rate was @percent@ , with a major complication rate of @percent@.
The overall content validity index was greater than @number@
The overall Cronbach's coefficient of @number@ was acceptable and changed minimally ( from @number@ to @number@ ) when items were removed.
The overall crude prevalence's rates were @number@ and @percent@ for chronic back pain and chronic arthritis / joints pain respectively.
The overall database consisted of @number@ brain coordinates that yielded an overall sample of @number@ healthy participants.
The overall database included @number@ messages.
The overall decrease in proteolytic activity in aging can promote and accelerate protein accumulation and metabolic disturbances.
The overall denouement is that exercise is so beneficial that it should be deemed a drug both for young and old populations.
The overall deterioration in mobility was greater in older patients ( p < @number@ ) .
The overall diagnostic yield was @percent@.
The overall economic cost of HF in @number@ was estimated at $ 108 billion per annum.
The overall effect test showed p = 0.01 , disclosing that such difference was significant.
The overall fatality rate was @percent@ ( 477 / 27 @number@ ) of medical admissions.
The overall frequency of 3-month PSCI was @percent@ , whereas that of dementia was @percent@.
The overall GQoL question , EQ-5D and OHIP-14 were regarded as appropriate instruments.
The Overall Haemostatic Potential ( OHP ) and Calibrated Automated Thrombogram ( CAT ) were used to globally assess coagulation function.
The overall hospital costs was €34 millions.
The overall impact of diabetes using the average weighted impact score from the Audit of Diabetes-Dependent Quality of Life questionnaire was calculated.
The overall impact of race was assessed by multilevel mixed-effects linear regression models that included empirically relevant covariates.
The overall incidence of cancer was @number@ events / person-months and the overall prevalence of cancer was @percent@.
The overall in-hospital mortality rate was @percent@ , with no difference between patients treated in academic versus community hospitals ( p = @number@ ) .
The overall mean gain score difference was @number@ in all domains of quality of life between the study group and the control group.
The overall mean gain score in the study group was @number@ versus @number@ in the control group.
The overall mean measure of On.AspR ( @number@ ) was @number@ ( @number@ Aspect Ratio ) .
The overall morbidity and mortality rates were @number@ and @number@ % , respectively.
The overall mycological cure at the end of the 2-year study showed a comparable benefit between the two groups.
The overall number of B cells seems to be stable or the decrease is moderate.
The overall number of nodes identified as hubs in posterior cortical regions decreased in older participants.
The overall number peaked in neonates then remained relatively unchanged.
The overall objective is to look backward in order to see ways forward.
The overall olfactory score is able to predict MCI with a good sensitivity and specificity ( @number@ and @percent@ respectively ) .
The overall predictive performance of CURB-65 score was comparable in CAP and NHAP.
The overall prevalence of all subtypes of sensory extinction was @percent@ ( @percent@ CI @date@ @number@ ) .
The overall prevalence of bothersome pain in the last month was @percent@ , afflicting @number@ million older adults in the United States.
The overall prevalence of E. granulosus in yaks was @percent@.
The overall prevalence of frailty based on the presence of @number@ or more frailty criteria was @percent@.
The overall prevalence of frailty syndrome in this population-based study was @percent@ ( @percent@ confidence interval ( CI ) @number@.55-8.57 ) .
The overall prevalence of H. pylori infection was @percent@ ( M : @percent@ vs. F : @percent@ ; P = @number@ ) .
The overall prevalence of IBS was @number@ % ( @number@ % CI @date@ @number@ ) .
The overall prevalence of individual Fried frailty phenotype markers ranged from @percent@ to @percent@.
The overall prevalence of known atheromatous disease was @percent@.
The overall prevalence of late-life mania was estimated to be @percent@ in the reported @number@ older psychiatric inpatients.
The overall prevalence of mild cognitive impairment ( MCI ) at baseline was @percent@.
The overall prevalence of suicidal thoughts was @percent@.
The overall prevalence of UI increases with age in both men and women.
The overall prevalence of UR was @percent@ , similar in men and women.
The overall prevalence ( @percent@ ) has been increasing since the 1970s , and it increased rapidly with age.
The overall procedure success rates were similar.
The overall quality of the evidence was low.
The overall rate of anticoagulation increased from @percent@ in the pre-DOAC era to @percent@ in the post-DOAC era ( p < 0.001 ) .
The overall rather small effect sizes observed for smoking-related variables suggest that LTL reflects smoking-related health hazards only to a very limited extent.
The overall response rate was @percent@ and the disease control rate was @percent@.
The overall results suggested poor accuracy for visual age estimation of juvenile faces.
The overall results suggested that MTHFR C677T was associated with the risk of PE.
The overall risk of stroke is around @percent@ per year and within the group higher degrees of stenosis are associated with higher risks.
The overall satisfaction rate was @percent@.
The overall scale Cronbach's α was @number@ ( subscales ranged from @number@ to @number@ ) , demonstrating good internal consistency.
The overall seizure recurrence was @percent@ after treatment with carbamazepine or valproate sodium.
The overall sensitivity strongly depends on the mean infection intensity.
The overall shape of the learning curve depended on the relative share of fast vs. slow phases of latent time reduction.
The overall small-world property seen in ε4- was preserved in ε4 + .
The overall stroke rate was @number@.6% : @percent@ ( ESRD ) , @percent@ ( CKD ) , and @percent@ ( NF ) .
The overall structure of the MAD2L2-CAMP complex in both crystal forms was essentially similar to that of the MAD2L2-REV3 complex.
The overall success rate in our series was @number@ % and rose to @number@ % in cases of primary surgery.
The overall survival and the LVAD related complications were retrospectively evaluated in these @number@ patients.
The overall survival rate was @percent@ at @number@ year and @percent@ at @number@ years.
The overall survival was not significantly different between the two groups ( @number@ mo. vs. @number@ mo. , p = @number@ ) .
The overall tone was somewhat more positive than negative.
The overall visual inspection indicated that the reduction of the NRC in PD should start at the ventrolateral portion of SNc and advance medially.
The overexpression of bta-mir-10020 significantly decreased the DsRed fluorescence in the wild-type expression cassette compared to the mutant type.
The overexpression of human COL17 in aged mouse epidermis suppresses IFE hypertrophy.
The overflow hypothesis suggested that when SAT is unable to expand sufficiently , fat overflows towards metabolically adverse ectopic depots.
The overlap of the theory with a multiplicity of other constructs is reviewed.
The overlapped nodes were mostly involved in an inferior-posterior pattern and were primarily related to auditory and visual perception.
The overlapping strategy analysis was used to maximize the sample size and to provide age- and education-adjusted normative data using a logistic regression analysis.
The overstimulation of prostate stromal cell proliferation by down-regulation of CFTR-enhanced PGE2 production and release during aging may contribute to the development of BPH.
The overview offers an integrated framework for understanding the disablement process , trends and their complex milieu of causes and consequences.
The overview on the establishment , main activities and results of The Gerontological Society of The Russian Academy of Sciences since @date@ .
The overview represents the recent most conspicuous findings in aging studies.
The overweight group had more eating disordered behavior , more body dissatisfaction , and lower physical quality of life.
The overwhelming majority of sports-related sudden deaths occur among those older than @number@ years of age.
The overwhelming majority of them stated that they found the test easy.
The Ovid and Google Scholar databases were utilized as well and provided no additional references for the two terms.
The oxidation-mimicking W42Q mutant of γd-crystallin formed non-native polymers starting from a native-like state under physiological conditions.
The oxidation of TOP thiol groups by peroxidases did not promote the inactivating oligomerization observed in the oxidation promoted by the enzyme aging.
The oxidative imbalance presented in older participants and increased in hypoxia participants had a direct effect on dehydrogenase cell distribution.
The oxidative index positively correlated with BMI , CRP , and HbA1c.
The oxidative stress imposed by reactive oxygen species ( ROS ) plays an important role in many chronic and degenerative diseases.
The oxidized proteins include advanced oxidation protein products ( AOPP ) derived from oxidation-modified albumin , as well as fibrinogen and lipoproteins.
The oxygen-limiting ( hypoxic ) microenvironment of tumors induces metabolic reprogramming and cell survival , but the underlying mechanisms involving mitochondria remain poorly understood.
The [ oxyHb ] changes were measured with @number@ channels of NIRS during VFT.
The p16 gene displayed similar ASncmtRNA-2 expression patterns , suggesting a possible co-regulation of the two genes.
The p16INK4a positive epidermal cells ( identified as primarily melanocytes ) were also significantly associated with more facial wrinkles and a higher perceived age.
The p27 expression was determined by Western blot from internal mammary arteries ( IMA ) obtained from CABG patients ( n = 13 ) .
The P2Y agonist UTP but not the P2X agonist α , β-methylene-ATP generated ATP release.
The P300 amplitude might index neural power or cognitive resources , which increase with maturation.
The P300 component of event-related potentials was also measured during a working memory task.
The P300 latency possibly indexes neural speed or brain efficiency.
The P450 CYP3A4 enzyme is responsible for the major metabolic N-dealkylation pathway.
The p53 gene acts highly selectively through multiple mechanisms.
The p53 tumor suppressor gene has recently been shown to mediate metabolic changes in cells under physiological and pathological conditions.
The p53 tumor suppressor protein has achieved stardom in molecular oncology owing to frequent inactivation in a large range of cancers.
The p53 tumor suppressor serves to secure genetic stability of multicellular organisms.
The p62- and PML-positive structures were more frequently found in NIHID cases.
The p62 / Ref ( @number@ ) P family of proteins is involved in the autophagic clearance of cytoplasmic protein bodies or sequestosomes.
The p66Shc adaptor protein has been in the spotlight of many researchgroups around the world for over adecade.
The p66Shc adaptor protein is an important regulator of lifespan in mammals , but the mechanisms responsible are still unclear.
The p66Shc gene has emerged as a novel gerontogene affecting health and life during aging.
The p73 gene is relevant for brain development , and p73-deficient mice display important malformations of the telencephalon.
The p75NTR / ExonIII- / - mice and APPSwe / PS1dE9 mice were crossed to generate transgenic AD mice with deletion of p75NTR gene.
The pace at which science continues to advance is astonishing.
The PaceMaker results also suggest a decay in the rate of change in DNA methylation with age.
The pace of reproductive aging has been of considerable interest , especially in regard to the long postreproductive period in modern women.
The package estimates several versions of SPM currently available in the literature including discrete- and continuous-time multidimensional models and a one-dimensional model with time-dependent parameters.
The PAD does not impair the endothelium beyond that which already occurs from comorbid conditions and cardiovascular risk factors in patients with claudication.
The PADR-EC score could potentially be used at hospital discharge to prioritise patients for interventions to prevent subsequent adverse drug reaction-related hospital admissions.
The Paediatric Bone Index is designed to have minimal relative standard deviation ( @percent@ ) , and the precision is determined to be @percent@.
The pain level was self-rated by using a visual Borg scale.
The pain perception level was recorded on a 0-10 point scale ( 0 = No pain ; 10 = Most severe pain ) .
The pain perception level was recorded on a 0-10 scale ( 0 = No pain ; 10 = Most severe pain ) .
The pain score with fractional erbium-doped glass was higher than that with fractional bipolar RF , but duration of scab shedding was shorter.
The PA intake in a free-living population has not yet been reported , however.
The PA intervention attenuated this effect ( PA = @number@ vs HE : @number@ min·wk , P = @number@ ) .
The PA intervention included a walking regimen with strength , flexibility , and balance training.
The paired data of @number@ @number@ children aged 5-16 years were analysed for the study.
The paired t test and mixed model were used to compare the differences.
The paired t-test and t-test for independent samples were applied in the intragroup and intergroup analysis , respectively.
The palate defect was about @number@ × @number@ cm.
The palate defect was @number@ × @number@ cm.
The panel also convened to develop a clinical consensus on the individual wrinkle pattern in Asians.
The panel of experts included @number@ Brazilian researchers ( physical therapists , medical doctors , nurses , and physical educators ) .
The panel of mediators of the pro-cancerous activity of senescent HPMCs appeared to be cancer cell line-specific.
The panel of selected miRNAs shows promise as biomarkers to discriminate mTBI from sTBI.
The paper concluded with some suggestions for future research.
The paper concludes with key recommendations for future research and practice in this area.
The paper concludes with recommendations for clinical assessment of sensory features in Autism.
The paper considers modern conceptions about the prognostic value of left ventricular hypertrophy ( LVH ) different types.
The paper deals with health problems of working-age population in the Russian Federation.
The paper describes the main specific and nonspecific ways of reactive oxygen species generation in the course of the disease development.
The paper describes the participation of parasites in the regulation of the physiology of development and reproduction of their hosts.
The paper ends with pointers for potential future research in this area.
The paper expands on the Vardis multiplicative censoring model ( Vardi , @number@
The paper identifies methodological issues of implementation and use of DCM , i.e. , coding practices , mapping duration.
The paper offers a rationale for the integration of both developmental research and action research , particularly community-based participatory inquiry.
The paper presents a structured overview of evidence from the revealed preference and stated preference literature in this area.
The paper presents major steps of gerontology development in Russia.
The paper presents the methodology and current status of the Task Force on EIP on AHA synergies.
The paper reviews human mastication , focusing on its age-related changes.
The paper reviews the ethnopharmacology , the biological activities and the correlated chemical compounds of Epimedium species.
The paper summarizes literature data on the importance of oxidative stress as one of the pathogenetic mechanisms in Alzheimer's disease.
The paper summarizes pathways for exocyclic adducts removal and describes how proteins involved in repair of these adducts can modify pathological states of the organism.
The papillary dermis and superficial reticular dermis are free of HA.
The papillary dermis is free of exogenous hyaluronans.
The papules were controlled under ultrasound and biopsies at D0 and D15.
The paradigm is relatively robust to optical blur and unlikely affected by motor dysfunctions.
The paradigm presented here provides a sensitive index of both memory resolution and feature binding , with the potential for assessing their modulation by interventions.
The paradoxical presence of increased , reactive microglia yet accumulating extracellular debris suggests that these cells may be phagocytically compromised during disease.
The paraffin embedding process can degrade RNA.
The parafoveal measure of the green : blue ratio , expressed in decibels , is proportional to the blue-light attenuation by the lens.
The parameters analyzed may lack the sensitivity necessary to detect differences in subjects with normal voices.
The parameters of subjective well-being in teachers and their significance in a possible reduction in work capacity and precocious retirement were studied.
The parameters of the differential model were difficult to estimate , and the goodness-of-fit of the power model was slightly inferior to the quadratic model.
The parameters selected amongst these studies seem to be done on the basis of convenience for the authors in most cases.
The parameters studied in healthy individuals showed age-related differences in the pool of saturated and unsaturated fatty acids ( SCFA ) .
The parameters that were disputed at the global level necessitate further discussion when using the framework at that level.
The parameters used in the FOG detection were optimized for each patient.
The parameters were measured with an electronic caliper.
The paraptosis is one cell death which is characterized by dilation of the endoplasmic reticulum and / or mitochondria.
The parasite-induced increase in the longevity of a host is accompanied ( provided ) by its reduced reproduction.
The parietal go-P3 latency was also delayed with aging , while the central nogo-P3 was more pronounced in older adults than in younger controls.
The parietal lobe is important for successful recognition memory , but its role is not yet fully understood.
The Parkinson's disease ( PD ) is a degenerative disorder of the nervous system and the cause of the majority of sporadic cases is unknown.
The parotid glands secrete about @percent@ of all saliva produced.
The PARQ is a succinct measure that captures positive and negative aspects of support and interactions in relationships between adults and their parents.
The partial PCC group had a greater likelihood than the non-PCC group of receiving @number@ types of preventive services.
The participant age was @number@ to @number@ years old at baseline , and the median observation time was @number@ years.
The participants also completed multiple physical tests that assessed health- and skill-related fitness.
The participants answered a survey on socio-demographic factors and health , had blood pressure measured and urine and blood samples collected.
The participants assigned to the exercise groups performed @number@ weeks of moderate intensity ( 55-65% VO2max ) exercise training.
The participants completed a single 3-hour sensory testing session where responses to thermal , mechanical , and cold stimuli were assessed.
The participants completed congruent and incongruent trials of a modified Stroop Test , during which , event-related potentials were recorded.
The participants completed detailed tests of olfaction , value-based decision making , emotional memory , and general cognitive ability.
The participants completed questionnaires of the frequency of food consumption and food preferences.
The participants completed the MAT twice within @number@ weeks.
The participants completing both the @number@ and @number@ waves were included for analysis in this study ( n = 3228 ) .
The participant's evaluation of their most recent sexual experience in terms of arousal , erectile difficulty , and orgasm all declined with age.
The participants experienced considerable impact of the new and increased impairments on their life situation.
The participants experienced stress and strain , although they were not the primary caregivers.
The participants had a valid driving license and drove at least once a week.
The participants had to have a close relative who was caring for an elderly family member with dementia.
The participants included @number@ women.
The participants in group C maintained the grip strength , while those in groups A and B exhibited decreased grip strength at 24-month follow-up.
The participants interviewed a total of four subjects in their respective countries.
The participants in the focus group interviews were @number@ older adults with a mean age of @number@ years ( range : 66-86 ) .
The participants in the post-intervention time also reduced BMI , SBP , and waist circumference.
The participants in the profiles differed in the proportion of individual and environmental barriers.
The participants in the Robust clusters reported leading a physically active lifestyle and participants in the Less robust cluster reported leading a sedentary lifestyle.
The participants made studied or unstudied judgments during the recognition phase.
The participants ( N = @number@ ) aged 65 + were included in the analysis.
The participants ' performance was evaluated by analysing their reaction times and accuracy , while employing a diffusion model analysis.
The participants reported an estimate of their sleep duration.
The participants responded when prices of a target company exceeded specific values , while ignoring all other companies.
The participant's sex , age and parental age at birth were used as covariants for adjusting confounding effects.
The participants underwent an overnight polysomnography and multiple sleep latency test ( MSLT ) the following day.
The participants were asked to draw a picture about their lived experiences of urinary incontinence in a self-portrait.
The participants were asked to selectively attend to the target sentence and repeat back the spoken words.
The participants were assessed using standardized scales.
The participants were assigned to good- and poor-stability groups on the basis of the stability index ( SI ) , using the Biodex® Balance System.
The participants were categorized into five age groups : 60-61 , 62-63 , 64-65 , 66-67 , and 68-69 years.
The participants were classified into @number@ groups on the basis of sex and age.
The participants were community-dwelling women and men aged 75-90 years ( N = @number@ ) .
The participants were divided into having major diseases or ADL disability or none.
The participants were divided into people with mild disability , severe disability , and without disability according to the Korean disability registration system.
The participants were followed for an average of @number@ years for the assessment of CVD events and mortality.
The participants were given a questionnaire on driving characteristics and questionnaire on driving adjustments.
The participants were healthy volunteers aged 50-81 , some of whom had elevated blood pressure , a known vascular risk factor.
The participants were @number@ adults aged 20-30 years and @number@ older adults aged 61-76 years.
The participants were @number@ children ranging in age from @number@ years , @number@ months to @number@ years , @number@ months.
The participants were @number@ community-dwelling older adults living in Tehran who were selected randomly from the primary health care centers.
The participants were @number@ elderly ( ≥65 years ) individuals , a cross-sectional sample from @number@ aged care homes.
The participants were @number@ HIV-infected and @number@ uninfected Hispanic and African American postmenopausal women.
The participants were @number@ individuals over @number@ years of age , who had been bedridden or suffered from dementia for more than @number@ months.
The participants were @number@ nondisabled men and women aged @number@ to @number@ years at the @number@ survey.
The participants were @number@ non-Hispanic blacks and @number@ non-Hispanic white adults , ages @number@ to @number@ years.
The participants were @number@ older adults with a mean age of @number@
The participants were @number@ parents with sons aged 15-30 years.
The participants were @number@ typically developing children ( control ) without cerebral palsy and @number@ children with cerebral palsy ( CP ) .
The participants were older people who met the study criteria and who lived in public housing in Wanhua District , Taipei City , Taiwan.
The participants were randomized into three groups : aquatic exercise group , non-aquatic exercise group and control group.
The participants were recruited randomly from all administrative regions of Poland by a three-stage , proportional , stratified-by-age group selection process.
The participants were reevaluated after six weeks.
The participants were required to write down the second word of the pair.
The participants were selected through convenience sampling and consisted of @number@ participants.
The participants were submitted to a working memory recognition paradigm , assessing proactive and reactive cognitive control by manipulating the interference level across items.
The participants were the elderly , their care-givers , physicians , and pharmacists.
The participants with better cognitive function were more independent in their performance of AADLs and IADLs.
The participants with hypertension had lower Mg concentration.
The participating @number@ employees with good self-rated health ( SRH ) at baseline were observed in @number@ 5-year time windows.
The participation of each of the four anatomic components and their approach in the facial rejuvenation surgeries are here in discussion.
The participation of mast cells in atherosclerosis is still an enigma and it may be of therapeutic interest to clarify this process.
The participation of master runners increased during the 1980-2009 period , to a greater extent for females compared to males.
The participation rate was @percent@.
The participation rate was @percent@.
The participation rate was @percent@ , and @number@ completed the questionnaire.
The particle sizes of both liposomes were approximately @number@ nm.
The particles size was @number@ @number@ @number@ and @number@ μm , respectively , for suspensions containing Na-CMC , ibuprofen alone , HPMC , and GG.
The particular aim was to investigate whether the response of blood lipids is associated with changes in body composition of blood lipid medication.
The partition coefficient was determined by the slope of the linear relationship of ( 1 / T1myo vs. 1 / T1blood ) .
The PARTNER approach aims to involve residents through collective action to improve their community life and wellbeing.
The partnership with the university , nevertheless , provided a point of stability and continuity for the project officers in implementing their mandate.
The partner's role is depicted as consultative and mostly supportive.
The passage from one state to another and vice versa is modelled by two functions r0 and ri depending on the total tumour size.
The past decade has seen outstanding scientific progress in the field of stem cell ( SC ) research and clinical application.
The past decade has seen significant progress of regenerative medicine in China , the world's most populous developing country.
The past few years have witnessed an increase in the development of wearable sensors for health monitoring systems.
The past two decades have seen remarkable progress in our understanding of the multifactorial drivers of hippocampal aging and cognitive decline.
The past two years have seen exciting progress in determining telomerase holoenzyme architecture and the structural basis of telomerase activity.
The past year has seen some extraordinary activity in clinical amyotrophic lateral sclerosis ( ALS ) research.
The PATE1 protein seems to mediate sperm-egg interactions ; however , the mechanisms are still unknown.
The pathogenesis and incidence of AFF are reviewed herein.
The pathogenesis differs between these two types of infarctions.
The pathogenesis for developing autoantibodies against these coagulation factors is still unclear.
The pathogenesis of aging-associated structural changes is not completely understood.
The pathogenesis of ALD , influenced by host and environmental factors , is currentlyonly partially understood.
The pathogenesis of Alzheimer's disease involves the progressive accumulation of amyloid β-protein ( Aβ ) .
The pathogenesis of brain AVM in HHT1 patients is currently unknown and no specific medical therapy is available to treat patients.
The pathogenesis of delirium and the mechanisms leading to these disabling consequences remain unclear.
The pathogenesis of dysgenetic CH is still largely unknown.
The pathogenesis of executive dysfunction in geriatric depression remains uncertain although causal bidirectional relationships with depression have been discussed.
The pathogenesis of fibrosis involves multiple cell types and extracellular signals , of which transforming growth factor-ß ( TGF-ß ) is pre-eminent.
The pathogenesis of HAND is multifaceted , and mounting evidence indicates that immune cells play a major role.
The pathogenesis of PUs is different at the heels , the sacral and upper back skin.
The pathogenesis of right ventricular fibrofatty changes can be broadly divided into genetic or acquired.
The pathogenesis of sarcopenia is complex and multifactorial.
The pathogenesis of secondary osteoporosis is almost always multifactorial.
The pathogenesis of sepsis is highly complex.
The pathogenesis of the arteriopathy is the key to understanding the differential progression of disease in various SVDs.
The pathogenesis of type @number@ diabetes ( T2DM ) in aging is characterized by two major features : impaired insulin secretion and peripheral insulin resistance.
The pathogenic mechanisms involved in the development of this disease are still unknown.
The pathogenic repeat expansion [ GGGGCC ] Posterior reversible encephalopathy syndrome ( PRES ) is diagnosed based on neuroradiological findings.
The pathogenic repeat expansion was detected in @number@ patients ( @percent@ ) .
The pathogenic role of AGEs in vascular diabetic complications is widely recognised.
The pathological characteristics of sIBM include two unique features : inflammatory changes in muscle fibers , and cytoplasmic and intranuclear inclusions containing several Alzheimer-type proteins.
The pathological consequences of ALEs tissue damage include inflammation and increased risk for many chronic diseases that are associated with a Western-type diet.
The pathological diagnosis included small cell lung cancer in @number@ cases , adenocarcinoma of lung in @number@ case.
The pathological end point of these interactions may facilitate a positive feedback loop resulting in increased penetration of HIV into the CNS.
The pathological processes of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases engender synaptic and neuronal cell damage.
The pathological response under supra-physiologic FSS magnitude peaked at @number@ hours but was then maintained until the 72-hour time point.
The pathological significance of this up-regulation is not known.
The pathological substrates associated with post-stroke or vascular dementia are poorly understood , particularly those associated with executive dysfunction.
The pathologic diagnosis was DLB neocortical-type with low-likelihood of Alzheimer's disease by NIA-Reagan criteria.
The pathologic effects of MYBPC3 and MYH7 were found to be independent of gene mutation location.
The pathologic hallmarks of Alzheimer's disease ( AD ) include senile plaque , neurofibrillary tangles ( NFTs ) , synaptic loss , and neurodegeneration.
The pathologies most studied are intracranial neoplasms and acute ischemic strokes.
The pathology of cervical spine affecting the intervertebral foramina of female which complaint earlier than male due to narrower foramina.
The pathology of TBI is complex and dependent on injury severity , age-at-injury , and length of time between injury and neuropathological evaluation.
The pathology underpinning CVD is atherosclerosis , a chronic inflammatory state involving the arterial wall.
The pathomechanisms of CAA remain unknown.
The pathophysiological mechanism by which OSA enhances hypertension may be linked to sympathoexcitation , oxidative stress , and endothelial dysfunction.
The pathophysiological mechanism is a complex immune and neuroendocrine dysregulation.
The pathophysiological mechanisms for these paradoxical situations need to be understood in at least two different ways , causal and non-causal.
The pathophysiological mechanism underlying Hashimoto's thyroiditis ( HT ) is still unclear.
The pathophysiological process of Alzheimer's disease ( AD ) is thought to begin many years before the diagnosis of AD dementia.
The pathophysiologic basis of @date@ -dependent cyst proliferation and disease progression , however , is not fully understood.
The pathophysiology is poorly understood , but it has been suggested that inflammation and oxidative stress may play a role.
The pathophysiology of both syndromes is incompletely described with multiple causes , inter-relationships and complex pathways proposed.
The pathophysiology of EED remains poorly understood.
The ( patho ) physiology of estrogen and its receptors is complex.
The pathophysiology of frailty is multifactorial and associated with comorbidities.
The pathophysiology of intervertebral disc degeneration has been extensively studied , but the etiology of this aging-related problem remains poorly understood.
The pathophysiology of lower urinary tract symptoms ( LUTS ) , particularly in the elderly , seems to be multifactorial.
The pathophysiology of osteoarthritis , which ultimately leads to joint destruction , is still poorly understood.
The pathophysiology of pelvic organ prolapse is believed to be multifactorial.
The pathophysiology of postoperative cognitive dysfunction ( POCD ) remains unclear.
The pathophysiology of primary progressive aphasias remains poorly understood.
The pathophysiology of SCAD is still not fully understood , and its management can be challenging.
The pathways through which this operates still need to be explored.
The pathway to diagnosis might be easier with outreach to help South Asian immigrants differentiate between normal aging and dementia.
The patient and her mother had a history of Raynaud's phenomenon.
The patient developed herpes zoster in the hospital , which challenged traditional treatments.
The patient did not have hoarseness , dysarthria , dysphagia , as well as other neurologic symptoms.
The patient died of sudden cardiac arrest at @number@ months after the onset of symptoms.
The patient group exhibited both global and regional cortical thinning in regions including the prefrontal and temporal cortices.
The patient had an ulcerous lesion which developed in the site of a trauma on the middle finger of the right hand.
The patient had an uneventful recovery , and his symptoms resolved.
The patient had repeated incidents of making expensive purchases and then had difficulty making payments.
The patient made an excellent recovery following cessation of valproate and commencement of dopaminergic therapy.
The patient mean age was @number@ years , @percent@ were female , and the mean LVEF was @number@.25%±5.76%.
The patient presented at the clinic with sharp jaw pain and swelling on the left mandible @number@ months after extraction of the third molar.
The patient presented many episodes of vascular access thrombosis that required endovascular interventions.
The patient presented with prominent behavioral changes in addition to the more typical cognitive and motorimpairments seen in sporadic Creutzfeldt-Jakob disease.
The patient received physical therapy and occupational therapy @number@ days per week for @number@ days in an SNF.
The patient recognized progressive weakness of extremities at age @number@
The patient reported frequent falls , but the neurological deficits remained unchanged.
The patient returned to normal life with minimum loss of pulmonary reserve and no recurrence of lung cancer for @number@ months.
The patient's age and length of time without circulating ovarian hormones are likely to be key factors in the specific neurological outcomes of hormone therapy.
The patients ' ages at the time of surgery ranged from @number@ to @number@ years.
The patients ' ages ranged from @number@ to @number@ years , with @number@ month to @number@ years of follow-up.
The patients also demonstrated a category effect with massive difficulties in recognizing human actions and musical instruments as compared to the other categories.
The patients also showed a statistically significant reduction in vestibular atrophy and cotton swab test at the end of treatment.
The patients and cadavers were of similar ages.
The patients are evaluated using validated risk assessment instruments , and the care is planned , executed , evaluated.
The patient satisfaction surveys at @number@ weeks showed better satisfaction on the BoNT / A treatment side compared to the MFR treatment side.
The patients ' average global aesthetic improvement score also indicated better cosmetic outcomes.
The patients ' biological skin age was also calculated so as to better quantify the benefits they obtained by giving up smoking.
The patients ' characteristics , postoperative clinical outcomes , and the medication records after TUR-P were compared.
The patient's comorbidities may provide clues.
The patients completed a posttreatment questionnaire pertaining to injection pain , adverse effects , and preference for vibration with future dermal filler injections.
The patients ' diagnoses included amyotrophic lateral sclerosis , multiple system atrophy , spinocerebellar degeneration , corticobasal syndrome , Parkinson's disease , and Huntington's disease.
The patient's drug-resistant status epilepticus markedly improved following second-line immunotherapy with rituximab and cyclophosphamide.
The patients ' EDSS and NRS scores were @number@.77±2.14 ( range : 1-7.5 ) and @number@.88±11.99 ( range : 42-94 ) respectively.
The patients ' education sessions are scheduled at @number@ @number@ @number@ @number@ @number@ and @number@ months following the start of the trial.
The patients had lost walking ability.
The patients had skin prototypes @number@ to @number@ and wrinkle degrees @number@ to @number@
The patient should be provided brochures to study and also adequate opportunity to seek information.
The patient showed overlap of the PLP1.
The patient showed remarkable improvement @number@ months after the procedure. < p > < em > J Drugs Dermatol.
The patients in the @number@ survey were also questioned as to whether they felt lonely in their single room.
The patient's knowledge of his or her genotype and risk of Alzheimer's disease should be considered when evaluating cognition in the elderly.
The patients ' mean age was @number@ ± @number@ years.
The patients'median age was @number@ years.
The patients must be @number@ years or older , use at least seven different medications and have their medications administered by the home nursing service.
The patient-specific computational models allowed us to predict the severity of the disease phenotype , providing a proof of principle for the systems medicine approach.
The patient's personal footwear from home is the safest footwear option while admitted into hospital.
The patients population consisted of @number@ subjects with a recent diagnosis of knee osteoarthririts of mild-moderate severity.
The patient's premorbid status should be carefully assessed.
The patients presented with a wide spectrum of liver diseases.
The patients randomized into the intervention group received pharmaceutical care intervention besides the usual care offered.
The patients received RT with median total doses of 60-66 Gy for the primary tumor and metastatic lymph nodes.
The patients reported a mean age of onset of @number@ years ( range = 13-38 , SD = 6 ) .
The patients reported high levels of satisfaction after treatment.
The patients represented @number@ different local health units.
The patients ' risk for conversion to AD because of CR was estimated by controlling for cognitive efficiency , MTA , and WMLs at baseline.
The patients scored significantly lower than the normgroup of healthy adults.
The patients sometimes needed to insist on being transferred to an examining table when physicians preferred to examine them seated in their wheelchairs.
The patients tended to be critical in regards to medication.
The patients treated with lipid-lowering drugs amounted to @number@ subjects ( @percent@ ) , with no gender difference.
The patients ' underlying disease and individual comorbidities rather than elevated vancomycin MICs determine adverse clinical outcomes in MRSA BSI.
The patients underwent sampling of fat by liposuction from the abdominal region.
The patient's urologist recommended he have a suprapubic cystostomy done in a hospital.
The patient survived and has an acceptable outcome.
The patient survived until @number@ years of age.
The patients were admitted with ACS.
The patients were allocated to the intervention group ( n = 206 ) or control group ( n = 202 ) .
The patients were all proved to have infrarenal AAA by computed tomography angiography ( CTA ) .
The patients were analyzed according to gender.
The patients were asked whether they noticed excess wrinkling of the hands when exposed to water.
The patients were assigned to the study or control group based on frusemide use.
The patients were classified into two groups according to age as those older than @number@ years and those younger than @number@ years.
The patients were divided in @number@ groups based on the amount of weight change.
The patients were divided into four groups on the basis of the use of β-blockers and β2-agonists.
The patients were divided into those treated within or after @number@ h using a receiver-operating characteristic curve.
The patients were divided into three age groups : @number@ to @number@ years , @number@ to @number@ years , and @number@ to @number@ years.
The patients were divided into three groups.
The patients were divided into two genotype groups : C homozygotes ( n = @number@ ) and T carriers ( n = @number@ ) .
The patients were divided into two groups with respect to the age of @number@ years , and differences were compared statistically.
The patients were evaluated at baseline , and @number@ and @number@ months ( M1 , M3 ) after the treatment using a quartile grading scale.
The patients were evaluated with the MADRS at admission to and discharge from hospital.
The patients were examined on tests of letter-writing ability.
The patients were followed up 12-30 months with an average of @number@ months.
The patients were followed up 2-8 months ( mean , @number@ months ) .
The patients were followed-up over @number@ year.
The patients were followed up periodically for at least @number@ months.
The patients were found to be homozygous for two novel mutations.
The patients were grouped according to the Clinical Dementia Rating ( CDR ) .
The patients were grouped in @number@ categories according to decade of life.
The patients were kept on VM for 1hour to observe the hemodynamic and respiratory stability.
The patients were mainly male ( @percent@ ) and of Han ethnicity ( @percent@ ) .
The patients were matched for diagnosis , sex , BMD of the lumbar spine and contralateral femur , Body Mass Index and age.
The patients were @number@.1±5.7 years post heart transplantation.
The patients were primarily female , Caucasian , @number@ years of age with Alzheimer's disease.
The patients were receiving highly active antiretroviral therapy ( HAART ) and secondary prophylaxis after VL therapy.
The patients were reevaluated at the end of the sixth month.
The patients were retrospectively divided into a transradial group ( n = @number@ ) and a transfemoral group ( n = @number@ ) .
The patients were seen in the clinic @number@ weeks after discharge.
The patients were selected on clinical grounds from National Institute of Cardiovascular Diseases , Karachi and Jinnah Postgraduate Medical Centre , Karachi , Pakistan.
The patients were stratified into @number@ age groups , and @number@ patients ( @number@ male and @number@ female ) were selected for each group.
The patients were supplemented for @number@ months with 6g / day of a certified fermented papaya preparation ( FPP ) .
The patients were treated in an acute hospital focusing on rheumatologic pain therapy and multidisciplinary complementary medicine.
The patients were treated with one session of autologous plasma filler.
The patients who are above @number@ years old may have less complication rates than the younger patients.
The patients who did not receive pain medication had an initial pain score of @number@ ( SD = @number@ ) .
The patients who died in / after their 70s demonstrated AGs similar to controls , except for the patient with CBD.
The patients who had optimum weaning criteria after the T-tube trial of 30minutes were extubated.
The patients who underwent Roux-en-Y gastrojejunostomy differed in incidence of postoperative ileus but not in severe postoperative complication rate.
The patients with ALS showed reduced empathy ( Fantasy scale ) and increased behavioural dysfunction with high levels of apathy.
The patients with cirrhosis reacted slower and with a higher degree of instability than volunteers.
The patients with PMO were commenced on @number@ mg of risedronate , @number@ mg of calcium , and @number@ IU of vitamin D daily.
The patients with the lower variable value account for a significantly higher mortality.
The patients with type @number@ diabetes mellitus with a longer duration of disease have an increased probability of suffering from benign paroxysmal positional vertigo.
The patient underwent a left lower lobectomy and the tumor was diagnosed as BSC by postoperative pathological examination.
The patient underwent neuroimaging , evaluation by neurology , and comprehensive neuropsychological testing to determine the nature of any other associated impairments.
The patient underwent phacoemulsification cataract surgery with implantation within the capsular bag.
The patient was a 28-year-old woman with bilateral pneumothorax secondary to LAM who had undergone thoracoscopic surgery in another hospital.
The patient was able to live enjoyably at home with her family before she was transferred to a palliative care hospital.
The patient was able to return home and live with her husband while requiring only incidental assistance with activities of daily living.
The patient was admitted to the emergency service due to sudden onset of abdominal pain.
The patient was akinetic with mutism , and clonic perseveration induced in the upper limbs was evident while she was examined.
The patient was a @number@ years old woman complaining of altered balance and low-back pain.
The patient was diagnosed with nonocclusive mesenteric ischemia ( NOMI ) , and a subtotal colonectomy was performed successfully.
The patient was pathologically diagnosed with FTLD with TDP-43-positive inclusions ( FTLD-TDP ) without motor neuron disease.
The patient was placed on an over-the-counter daily oral polyphenolic mixture containing resveratrol and re-evaluated @number@ months later.
The patient was started on androgen replacement therapy , but his symptoms did not improve.
The patient was treated properly with surgical debridement and itraconazole therapy.
The patient was treated with CHOP regimen @number@ times.
The patient with history of previous acetabular fracture walks with two crunches and is still waiting for total hip arthroplasty.
The patient with sporadic FTD presented primarily with deteriorating behavior and mental status.
The patient with the CS showed atrophy of the pupillary rim and a subcapsular cataract.
The pattern and overall 24-h level of whole body protein balance differed per individual.
The pattern matching rules for identifying age are explained and enacted following a discussion on how to minimise false positives.
The pattern of amnesia in Korsakoff patients was not affected by examining only one event per life-period.
The pattern of antibiotic resistance with respect to the age of patients depended on the antibiotic mode of action.
The pattern of BMI change may also depend on the initial BMI.
The pattern of calcification was classified as marginal , granular , and central.
The pattern of changes in cutaneous sensation varied according to the site tested with smaller changes on the fingers compared to the palm.
The pattern of consumption of various nutrients was analyzed in detail.
The pattern of correlations between the reasons for tanning and appearance orientation was similar for girls and boys.
The pattern of dSWM changed with the age of AD onset.
The pattern of findings was not modified by gender , apolipoprotein ε4 status , education or current memory performance.
The pattern of findings was similar for IADLs.
The pattern of hemodynamic response was not related to regional gray matter volume loss.
The pattern of regional progression of neurofibrillary degeneration in AD to some extent inversely recapitulates ontogenetic and phylogenetic brain development.
The pattern of results showed that visual memory performance was better for negative stimuli than for neutral ones , irrespective of the group.
The pattern of results was similar across age groups and experiments.
The pattern of significant correlations between the ADAPS , KMAQ , and ADKS supported the convergent validity of the ADAPS.
The patterns are consistent between patients and are predictable.
The patterns of association between age and suicide rate vary by country , subpopulation and gender , and over time.
The patterns of associations by gender were not consistent and tended to diminish after adjusting for indicators of health and life circumstances.
The patterns of development differed for the three spinal regions and between genders.
The patterns of EC deposition in murine BrM wholemounts are comparable with findings in human BrM wholemounts.
The patterns of effects across these two anagram types for the two groups of readers were very similar.
The patterns were largely age-dependent and overlapped in a sizeable part of the population.
The pattern was similar for the prevalence of chronic diseases by raised WC.
The PB1 mathematical growth model was utilized to derive biological parameters of the adolescent growth curves.
The PBPA intervention is delivered at a local YMCA , and a regional grocery store chain donates the food to the food bank.
The PCA-biplot technique highlighted important trends or red flags that should be considered when evaluating recurrent falls in elderly females.
The PCA method was used to build an integral formula of the BA for the population.
The PCA model should be considered as a framework for similar efforts aimed at creating age-friendly communities.
The PCL beads were located stably at the applied urethra site ( urinary incontinent SD rat ) without migration to provide a passive bulking effect.
The pCR rates between the carboplatin and noncarboplatin arms were compared.
The PCR-RFLP method were used to determine the distributions of selected alleles and genotype frequencies.
The PDA collects information about participation in society and employment , independent living , health conditions , safety and living environment.
The PD group showed similar scores to those of the control group on semantic categorization.
The PD patients scored lower than controls on the EXAMINER Executive Composite , Cognitive Control , and Working Memory Scores.
The PDQ-39 , the PDQ-8 and other scales were administered.
The PDQ-8 replicated the results of the PDQ-39 well at all follow-up time points ( intraclass correlation coefficient : @number@.96-0.98 ) .
The peak amplitude of sodium currents recorded in adult atrial cells was significantly larger than that in pediatric atrial myocytes.
The peak applied force ( F1 ) occurred a mean ( ± SD ) @number@ ( ± @number@ ) ms after impact.
The peak creatine kinase was significantly higher in HR group versus the normal response group.
The peak creatinine phosphokinase level , left ventricular ejection fraction and in-hospital mortality rate were similar between the two groups.
The peak effect occurred later at rest than at maximum tension.
The peak hip abductor moment of the stepping limb was @percent@ larger by older adults compared to younger adults ( p < 0.001 ) .
The peak incidence of HCC is around @number@ years.
The peak of incidence of malignant tumors of maxillofacial region falls on the elderly life.
The peak of the rhythms occurred in early afternoon.
The peak of this P3b was delayed , and its amplitude reduced in the older , compared with younger , adults.
The peak stress for S / ST was significantly higher than for VS / VST ( P < 0.0001 ) .
The peak stress for S / ST was significantly higher than VPS / VPST ( P = 0.025 ) .
The peak stress for VPS / VPST was significantly higher than for VS / VST ( P < 0.0001 ) .
The peak tangential velocity of the wrist in either hand appeared significantly earlier in the elderly group than in the young adult group.
The peak-to-peak amplitude also decreases by age and is lower in overweight subjects.
The Pearson correlation coefficient for total densitometry was r = @number@ ( p < @number@ ) .
The Pearson one-way ANOVA was used to compare data between the groups.
The Pearson's correlation coefficient was @number@ indicating that @percent@ of the aging-induced reduction in bond strength can be explained by the degradation of collagen.
The peculiarities of clinic course of stomach cancer and its relapse were analyzed in @number@ histories.
The peculiarities of neurodegenerative processes during normal aging and aging with Parkinson's disease are discussed.
The pediatric choroidal thinning with increasing age is more rapid in the central area.
The PEG-patterned surfaces are also applicable to detect apoptotic HeLa cells.
The pelvic floor guards the passage of the pelvic organs to the exterior.
The pelvic inlet did not enlarge over time while the distance between the hips and the femoral head diameter did significantly increase.
The pelvis changes in females with age and reproduction-related changes in hormones.
The pelvis , one of the most important cavities in the human body , is involved in human reproduction health.
The penetrance of the phenotype is widely distributed , even though a consistent genotype is assumed in @percent@ of the cases.
The People's Republic of China has the largest population of older persons of any country in the world.
The people who are treated in the community setting will often have multiple comorbidities.
The people who were more likely to use the services tended to have more intensive consultation support.
The PEP program decreased depression and improved a measure of physiological health in older dementia caregivers.
The pepsin digestible collagen fraction was significantly less modified in comparison to the collagenase digestible fraction.
The peptides injection decreased the frequency of cancerogenesis and increased physiological resource of cells , tissues and organism till 20-42%.
The peptides KEDW and AEDL tissue-specifically affect gene expression in pancreatic and bronchial cell cultures , respectively.
The peptides were all detected in their intact forms in the blood.
The perceived barriers and facilitators differed with gender as a result of the characteristics of Korean culture.
The percentage contributions of each in explaining health disparities were calculated.
The percentage decline in gait speed after @number@ years was @percent@ in men and @percent@ in women.
The percentage DNA methylation in the CpG sites of the IL1β and MMP13 proximal promoter were quantified by pyrosequencing.
The percentage improvements of rhytides evaluated by the investigators were mostly similar to those found from in vivo measurements.
The percentage loss of ASM in @number@ years was @percent@ and @percent@ in men and women , respectively.
The percentage mismatch lost was not different between men and women ≥71 years old ( @percent@ in both groups ) .
The percentage occurrence of meridional fibers decreased significantly from the inner to the outer layers of the posterior sclera ( P < @number@ ) .
The percentage of all insulin exposures that were unintentional therapeutic errors increased progressively , from @percent@ to @percent@.
The percentage of asymptomatic patients with palmar fibromatosis was calculated.
The percentage of ceiling and floor effects were below @percent@ , except the ceiling effect in the Impact domain ( @percent@ ) .
The percentage of colon cancer in all CRCs increased significantly.
The percentage of colon cancer in all CRCs increased significantly for both males and females between the periods of 2000-2002 and 2010-2011.
The percentage of diffuse colonies was also found to correlate with the SA-βgal positive cells in mass culture.
The percentage of elderly persons is rapidly growing.
The percentage of facilities having residents who received LTC services paid by Medicaid varied by facility size.
The percentage of long-lived people in the area was closely related to the macro- and micro-element contents of their staple food , rice.
The percentage of morphologically normal spermatozoa has no prognostic value for individual IVF / ICSI patients.
The percentage of naive T cells showed a strong correlation with measured TCR diversity and decreased linearly up to age @number@
The percentage of non-Caucasian individuals seeking these treatments continues to rise.
The percentage of once over-drinking was @percent@ ( @number@ ) .
The percentage of optimal , normal , and high normal blood pressure was : @percent@ , @percent@ , and @percent@ , respectively.
The percentage of patients receiving osteoporosis evaluation and treatment increased significantly.
The percentage of patients with a CHA CONCLUSION : The incidence and prevalence of AF gradually increased from @number@ to @number@
The percentage of patients with group B blood declined with age ( P < @number@ ) .
The percentage of PECAM-1 positive cross bridges declined progressively from almost @percent@ at @number@ days gestation to less than @percent@ in adults.
The percentage of questions answered with \ "don't know \ " ranged @percent@ to @percent@.
The percentage of readmissions rated as potentially avoidable was @percent@ and @percent@ according to hospital and SNF staff , respectively.
The percentage of receptors using the given Vβ gene is determined by flow cytometric analysis of T cells stained with anti-Vβ family antibodies.
The percentage of receptors using the Vβ gene in combination with the chosen Jβ gene is determined by quantitative PCR.
The percentage of subjects with SMC was @percent@ among persons diagnosed with depression or anxiety , and @percent@ among subjects without.
The percentage of Th17 cells in PBMCs and the serum IL-6 level are potential biomarkers for predicting disease progression.
The percentage of the cochlear volume that received @number@ Gy or greater , @number@ Gy or greater , and @number@ Gy or greater was calculated.
The percentage of the different fibre types did not change during aging.
The percentage of unprotected individuals at the time of enrollment differed substantially for tetanus ( @percent@ ) and diphtheria ( @percent@ ) .
The percentages of \ "perfect margin \ " after aging ranged from @percent@ to @percent@ in enamel and @percent@ to @percent@ in dentin.
The percentages of readmissions in each cohort attributable to the top three readmission diagnoses were examined.
The percent agreement was @percent@ , sensitivity @percent@ and specificity @percent@.
The @percent@ centre , @percent@ surround condition was also presented for 100ms duration.
The @percent@ confidence intervals of the controls were used as reference values.
The percent correct scores for each of the five serial positions were analyzed comparing the two listening conditions for YA and MA.
The @percent@ exercise was associated with greater central fatigue whereas the @number@ and @percent@ exercises involved mostly peripheral fatigue.
The @percent@ growth inhibition concentrations of GO-Y030 ranged from one-11th to one-14th of those of curcumin.
The @percent@ limits of agreement were : @number@ to @number@ cm for men and @number@ to @number@ cm for women.
The @percent@ limits of agreement were widest for youngest age groups and narrowest for the oldest participants.
The @percent@ non responders developing hyperglycemia survived 3-4 months longer than their untreated littermates.
The percent of fractured individuals was similar , but the mean number of fractures per individual was lower in IGHD than CO.
The percentual tissue damage due to the peeling was calculated , and a one-sample t-test for statistical significance was performed.
The percent variation in blood viscosity was not associated with the percent variation in any of the CHD risk factors.
The perception of elderly people to society can variously affect ( positively or negatively ) quality of life in this age group.
The perception of event structure in continuous activity is important for everyday comprehension.
The perception of menopause , menopausal attitudes , and problems faced during this period vary from one society to another.
The perceptions of cognitive aging of African American and Hispanic older adults are also described.
The perceptual organization index ( POI ; IQ subcomponent ) of the rice group was significantly higher than that of the bread group.
The performance cost of including the central task was measured and found to be negligible for younger adults.
The performance of balloon-type gastrostomy devices was evaluated in an accelerated aging failure mode as well as a feeding tube interlock pullout failure mode.
The performance of cTnI hs-ARCH was evaluated in patients with CHF by comparing it to findings with other @number@ methods.
The performance of each group in Catalan and Spanish was more similar than different.
The performance of many everyday activities requires the coordination of the two upper limbs to achieve the goal of the task.
The performance of @number@ children from four to fourteen years of age and @number@ adult rhesus monkeys was compared.
The performance of older adults relative to younger adults therefore depends on the relative importance of each type of intelligence for the decision at hand.
The performance of our proposed method is illustrated via extensive simulation studies.
The performance of the proposed age group prediction scheme was evaluated using the leave-one-out cross validation method and found to exceed @percent@ accuracy.
The performance of the proposed system is evaluated by testing it on @number@ MR images from the Osteoarthritis Initiative ( OAI ) database.
The performance of these patients was compared to a group of @number@ patients with Alzheimer's disease and @number@ healthy controls.
The performance of the Sweet @number@ is equivalent or superior to that of the MMSE.
The performance of the two educated groups was similar on all versions of the BNT.
The performance of the two groups in the VSM was compared and correlated with performance in established neuropsychological tests.
The performance of this tool was assessed through ROC analysis.
The performance on low-template samples also was not different.
The performance on the neuropsychological tests was equivalent to the average scores of previous normative Greek samples.
The performance pattern may reflect a trade-off between speed and accuracy that can guide clinical recommendations for maintaining patient independence.
The performances of the estimated GFRs were compared with those of the standard GFRs measured by technetium-99m acid.
The performances of the three automatic segmentation methods were evaluated by comparing with the manual segmentation method.
The perfusion ASL data from @number@ consecutive preterm neonates ( PN ) studied at term-equivalent age and @number@ TN were evaluated.
The pericentrin gene ( PCNT ) has sequenced in 21q22.3 inside of the minimal critical region for Down's syndrome.
The perimenopausal period puts women in a more vulnerable state in regard to certain functions such as memory.
The period between questionnaire administrations was @number@ weeks.
The period between the MRI and the FDG PET / CT examinations was within @number@ week.
The period of stay in the hospital was 2-4 weeks.
The period of treatment for both the groups was @number@ days , and minimum cost analysis was used to analyze the treatment.
The perioperative management of the elderly has to be of maximum standardised quality.
The perioral cosmetic treatment options can be divided into various lifting procedures and volumising techniques.
The perioral region is unique and important in the face , both from a functional and an aesthetic point of view.
The periorbital complex is a critical cosmetic unit.
The periorbital region deserves special mention given the overall differences in aesthetics between sexes.
The peripheral and central changes may be the key factors for these different characteristics.
The peritendinous concentrations of PINP increased significantly in the placebo group as a result of the run , as shown previously.
The permanent fillers , such as the ones derived from silicon oil and minerals are not biodegradable and may cause serious and irreversible side effects.
The Persian version of Word Association Test content validity index was @number@ %.
The persistence of the pseudohomophone effect across all grades illustrates the importance of phonological recoding in Dutch readers.
The persistent DNA damage in pancreatic tissue may be the source for its tumorigenesis.
The Persistently high comorbid class was characterized by a concentration of disadvantages over the life course.
The personal component was analyzed in terms of functional limitations , and the environmental component in terms of physical environmental barriers.
The Personal Genome Project ( PGP ) provides unrestricted access to genomes of individuals and their associated phenotypes.
The personalised diagnostic algorithms in the future should be therefore based on the combination of multiple biomarkers.
The personal reflections of @number@ graduate nursing students who attended a presentation by Susan J. Loeb on @date@ were included in this report.
The personal relevance of the survey topic was positively related to response consistency in multiperson households.
The person-item map showed that these assessments were difficult for our participants.
The person reliability coefficients of these assessments ranged from @number@ to @number@
The person separation index ranged from @number@ ( Symptom domain ) to @number@ ( Activity domain ) .
The person separation index was @number@.82-0.85 , indicating a good reliability.
The perspectives of formerly homeless , older women are absent in the academic literature on aging and homelessness.
The perturbation was then delivered after a random delay.
The pervasive application of credit scoring has outpaced knowledge about why credit scores are such useful indicators of individual behavior.
The PET cutoff values derived from an unsupervised classifier converged with previous PET cutoff values and the established CSF Aβ1-42 cutoff levels.
The PET visual interpretation predicted conversion to AD during 3-year follow-up with an overall diagnostic accuracy of @percent@.
The PFS showed strong internal consistency ( Cronbach's alpha @number@ ) and excellent test-retest reliability ( intraclass correlation @number@ ) .
The p.G257R mutation displayed diminished levels of palmitoylation , a post-translational modification crucial for trafficking of proteins to the cell membrane.
The PG also showed significant improvement in the Activities-Specific Balance Confidence Scale ( mean difference = @time@ , p = @number@ ) .
The PG exercises were performed twice weekly for @number@ weeks.
The PG received rehabilitation intervention during hospitalization for lumbar decompression surgery.
The pH and transit time of the GI tract varies with age , with the greatest changes occurring during the neonate's first month.
The phantom study indicated a FWHM of @number@.72mm.
The pharmaceutical and cosmetic industries have recognized the huge potential of these privileged frameworks and believe them to be a promising alternative to contemporary drugs.
The Pharmaceutical Care Network Europe Classification Version ( PCNE ) @number@ was used as a tool to classify DRPs.
The pharmaceutical industry introduces these new methods for validating manufacturing processes , or for quality control assessments.
The pharmacodynamics and pharmacokinetics of medications , their therapeutic and toxic effects are age dependant.
The pharmacological activation of cellular stress responses could be a new strategy to combat protein conformational diseases.
The pharmacological management of pain includes the use of nonsteroidal anti-inflammatory drugs ( NSAIDs ) .
The pharmacological properties of glucocorticoids are useful to counteract some pathogenetic mechanisms of tendinopathies.
The pharyngeal phase was mainly mediated by the pharyngeal plexuses of both the glossopharyngeal and vagus nerves.
The phase changes in these regions were used to estimate local iron concentration.
The pH cycling caused a reduction in the superficial enamel microhardness close to the cavity wall.
The phenol acts as a protective agent involving various body constituents.
The phenomenology of negative hallucinations provides quite an amount of information on the origin of the psychotic symptoms when one is rather old.
The phenomenon commonly described as the middle-age spread is the result of elevated adiposity accumulation throughout adulthood until late middle-age.
The phenomenon has an uncertain future , however , as the main proponents and supporters are aging.
The phenomenon of cross-limb transfer , in which unilateral strength training can result in bilateral strength gains , has recently been tested for ballistic movements.
The phenomenon of greying population has changed the attitude towards the old but common observations prove that quality of geriatric care is still unsatisfactory.
The phenomenon of hippocampal long-term potentiation ( LTP ) is widely used in studies of memory formation and storage.
The phenomenon of skin aging includes thinning of skin losses of elasticity and moisture , pigmented spot formation , and wrinkle development.
The phenomenon was reversible which indicates its therapeutic potential.
The phenothiazine neuroleptic trifluoperazine , an activator of macroautophagy , selectively reduced one particular alpha-synuclein species and rescued cells.
The phenotype appeared to progress with age , but BTM did not suggest increased bone formation.
The phenotype of CD28 ( - ) and CD28 ( + ) T cells was determined by flow cytometry.
The phenotypic data gathered included subjective , biochemical , nerve conduction , electromyography , and muscle magnetic resonance imaging data.
The phenotypic diversity amongst laminopathies is hypothesized to be caused by mutations affecting specific protein interactions , possibly in a tissue-specific manner.
The phenotypic outcome of the telomere-triggered transposon activity is the saltatory appearance of nonadaptive characters simultaneously in many individuals.
The philosophy for brow lifting and brief overview of current brow lift techniques will also be presented.
The phonetographic analysis involved @number@ relatively healthy subjects ( @number@ men and @number@ women ) divided into two age-matched groups.
The phosphatidylserine expression amounted to 0·25 ± 0·20% in RTH-RBCs and 0·07 ± 0·12% in RC-RBCs.
The phosphodiesterase type @number@ inhibitors ( IPDE @number@ ) revolutionized the treatment of ED.
The phosphoinositide 3-kinase-Akt signaling network may be the common denominator that links these areas together.
The phospholipid content of purified myelin was determined by BACKGROUND : Back pain and disc degeneration have a growing socioeconomic healthcare impact.
The phosphorylated form of NRIF then translocates to the nucleus and induces the expression of pro-apoptotic proteins.
The phosphorylation induces a brief activation of SIRT1 function and degradation of SIRT1 thereafter by the proteasome.
The phosphorylation of extracellular signal-regulated kinase ( ERK ) and Akt was also enhanced by 20GPPD in a dose-dependent manner.
The photo-assisted anthropometric measurements investigated gave reproducible results related to perioral aging.
The photogrammetric method was used to evaluate body posture using the phenomenon of the projection chamber.
The photographic scale was highly consistent with the clinical judgment.
The photographs of these patients were presented to @number@ blinded raters , each of whom was randomly assigned to @number@ rater groups.
The photography scaling and self-assessment questionnaire revealed no significant changes in either group.
The photomicrographs were evaluated using ImageJ software and the percentage of the area affected by the color reaction was assessed.
The photomorphometric study further showed an increase of prolabium skin at the cost of a decreasing visible upper lip vermilion.
The photoprotection was paralleled by decreases in the elastases-type protease activity and expression in solar-irradiated fibroblasts.
The photosensitizer used in fluorescence-guided surgery persists in the remaining peripheral tumor extensions.
The PHQ-9 and SCID show more agreement on items unrelated to PD manifestations.
The PHQ- @date@ performed equally well as the PHQ-9 , but would be more efficient for the agency to administer.
The PHR use by the low-income elderly was limited due to poor technical skills and low physical / cognitive abilities.
The pH value was @number@ while blood faecal test was positive.
The PHV was @number@ cm / yr in boys and @number@ cm / yr in girls.
The phylogenetic order of cerebral myelination helped to further explain the intersubject variability in GM thickness.
The physical ability of older women was positively correlated with the lengths of their somatic telomeres.
The physical activity of elderly people may decrease , because of the health problems or think that with aging sport activity should be reduced.
The physical and intellectual domains of wellness are prominent aspects in protection from cognitive decline.
The physical and psychological status and laboratory values are evaluated at the yearly follow-up doctor visits.
The physical characteristics of typical liposomes and CPP-conjugated liposomes containing P. aviculare extract were evaluated.
The physical component of the SF-8 was also lower in the low protein group but did not remain significant when controlling for BMI.
The physical examination included body mass index , Pelvic Organ Prolapse Quantification measurements , and pelvic muscle strength ( Oxford scale ) .
The physical examination included height , weight , waist circumference , blood pressure , blood glucose and blood lipids.
The physical fitness tests consisted of @number@ items to measure balance , agility , flexibility , muscle strength , and endurance.
The physical fitness was assessed using bio-behavioral measurements ( strength , lung capacity , speed ) .
The physical , functional , emotional , social , and spiritual well-being of individuals with MDS can be affected by both disease and treatment-related factors.
The physical-function effect of the implicit intervention surpassed a previous study's effect with participants of similar ages.
The physical function findings are promising and require further evaluation as frail women are at high risk for falls and fracture.
The physical functioning , social support , optimism , meaning in life , and subjective well-being of the participants were measured.
The physical interaction between MUC1 cytoplasmic domain ( MUC1-CD ) and JNK1 was established by GST-pull-down assay in vitro and co-immunoprecipitation assay in vivo.
The physical interaction of HDAC3 with normal and polyQ-expanded ataxin-7 affects the toxicity in a polyQ-dependent manner.
The physical part includes technologies that make living easier and more autonomous.
The physical reality of living with HIV thus shapes relational networks , making self-care a social practice.
The physicians ' helpful suggestions will be added to future SQA test versions.
The physicians reported significantly more frequent use than registered nurses and occupational therapists.
The physiological changes accompanying inflammation may alter the pharmacokinetics ( PK ) of certain medications.
The physiological consequences of changes in CMA activity depend on the substrate proteins present in a given cell type.
The physiological effects of the dietary polyphenol resveratrol are being extensively studied.
The physiological functions of ODx in eukaryotes remain unclear.
The physiological functions of -synuclein remain to be fully defined , although recent data suggest a role in regulating membrane stability and neuronal plasticity.
The physiological importance of H₂S is motivating efforts to develop strategies for modulating its levels.
The physiological outcome of injury-induced Ca²⁺ inflow is , however , unknown.
The physiological performance parameters cannot be referred to elderly persons.
The physiological range of laxity at the SL and lunotriquetral joints is wider than originally described.
The physiological responses to nutrient availability play a central role in aging and disease.
The physiological roles of the protease inhibitor SERPINB3 ( SB3 ) are still largely unknown.
The physiological significance of such interaction remains unclear.
The physiologic and pathological significance of lens crystallins in corneas deserves more investigation.
The physiology of reproductive senescence in women is well understood , but the drivers of variation in senescence rates are less so.
The physiotherapist evaluated @number@ qualitative features typical for the age of @number@ months in the prone and supine positions.
The Physiotherapy Evidence Database ( PEDro ) scale was used to assess quality of all studies included in this systematic review.
The phytochemical and pharmacological activities of C. rotundus have supported its traditional as well as prospective uses as a valuable Ayurvedic plant.
The phytochemical investigation revealed the presence of steroidal saponins , flavonoids , phenylpropanoids , alkaloids , steroids , organic acids , anthraquinones , and others.
The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological processes including cellular energy storage , growth , and survival , among others.
The PI and the sagittal positional parameters were measured on large radiographs in standardized standing position.
The PIB-binding site may represent a particularly pathogenic entity and / or report local pathologic conditions.
The PiB uptake was quantified as a region to cerebellar cortex ratio.
The PICALM rs3851179 A allele is thought to have a protective effect , whereas the G allele appears to confer risk for AD.
The picture that has emerged is worrisome from the point of view of translation.
The pigmented groups with opacifier presented the lowest ΔE values , with a statistical difference from the other groups.
The pilot stage confirmed that the protocols are well fitted to reach our goals.
The pilot study showed high appraisal of the strategy by both physical therapists and patients.
The pink vests quickly alert disaster rescue and response workers of LTC residents with special needs.
The pioglitazone group improved cognition and rCBF in the parietal lobe , while the control group showed no such improvement.
The pioneers and main proponents of the procedure are described here.
The pipeline we proposed and the implication the results suggest may be helpful in the research of other complex diseases.
The Pittsburgh Sleep Quality Index ( PSQI ) provides a means of examining these separate aspects of sleep.
The Pittsburgh Sleep Quality Index ( PSQI ) was used to assess sleep variables.
The Pittsburg Sleep Quality Index , actimetry and specific tests for frailty phenotype variables were used.
The Piwi-piRNA pathway also operates in tumorous cells and in somatic cells of certain organisms , including hydras , which likewise exhibit immortality.
The PK / PD parameters and treatment outcomes of VCM were compared between the two groups.
The p.L83Q ( human p.L71Q ) failed to localize to the mitochondria.
The placebo group received identical capsules comprising liquid paraffin oil.
The placebo group received standard health recommendations only.
The placenta is a tractable model of aging in human tissue.
The placenta used in the study was sourced during a Cesarean section.
The placenta , which is a complex multi-tissue organ , serves as the primary transducer of bidirectional information between the mother and fetus.
The place of residence is an important predictor of TM / CAM use.
The planar cell polarity ( PCP ) pathway is critical for the embryonic development of many organs , including kidney and lung.
The plant × animal design was orthogonal.
The plantar fascia thickness and elasticity modulus value were measured at the insertion of the calcaneus and at @number@ cm from the insertion.
The plantar fat pad of the human foot is a specific tissue made up of adipose chambers enveloped by fibrous septa.
The plasma Aβ40 / Aβ42 ratio increased in the control group , but showed no significant change in the pioglitazone group.
The plasma concentration of erlotinib ( Ce ) was measured at steady state on day @number@
The plasma concentrations of two lipid subclasses , triglycerides and ( GM3 ) , were different between PD and control participants.
The plasma kallikrein-kinin system modulates cerebrovascular tone through release of vasoactive bradykinin ( BK ) .
The plasma leptin levels were higher under catecholamine depletion compared with placebo in the whole sample ( treatment effect ; P = .0004 ) .
The plasma malondialdehyde ( MDA ) level and advanced glycation end-products obtained after dioscorin oral administrations were lower compared to the Gal group.
The plasma proteomic profiles of neonates were strikingly dissimilar to the older children and adults.
The plasma RCS concentration in different age groups showed a nonlinear association with age.
The plasma samples were collected from @number@ adult women as part of a case-control study of arsenic and myelomeningocele risk in Bangladesh.
The plasmatic level of CXCL7 at baseline was correlated with progression-free survival ( PFS ) .
The plasticity model predicts that respiratory complexes exist and function both as single complexes and as supercomplexes.
The platform also expands from the size of a standard microscope slide to a 96-well format , enabling parallel processing.
The platform-free and species-free nature of EpiDiff makes it potentially applicable to a wide variety of epigenomes at an unprecedented scale and resolution.
The platysma ascended upward and medially ( @percent@ ) or ascended from the clavicle to the face ( @percent@ ) .
The platysma muscle was identified and isolated during the procedure.
The platysma was located @number@ cm inferiorly from the malar eminence along the malar mandibular line.
The pleiotropic actions of melatonin in different physiological and pathological conditions indicate that may be basic cellular targeted for the indole.
The pleiotropic cytokine , interleukin-6 ( IL-6 ) , has emerged as a key factor in the biology of aging and the physiology of inflammation.
The pleiotropic effects of citrulline in aging could be due , at least in part , to the anti-inflammatory effect of citrulline.
The pleiotropic effects of KSR2-rs7973260 on metabolic phenotypes were also explored.
The pleiotropic effects of RES in cells of the immune and endothelial system were examined in this study.
The pleiotropic effects of statins including effects on inflammation and oxidation may mediate a decrease in the rate of cataract formation.
The pleiotropic effects of the ghrelin / GHS-R system suggest their exploitation to prevent and treat a number of clinical conditions.
The pleural effusion disappeared , and so did the bradycardia.
The PLFI is examined using longitudinal data from the Health and Retirement Study ( HRS ) database , for which it was developed.
The plot of predicted age versus actual age was linear , p < @number@ with a slope of @number@ and r = @number@
The PLT showed the correlation to the body angle at the start of PLT , but it was uncorrelated at the end of PLT.
The PLTs of the three kinds of fall activities were slightly different , but there was a significant difference between two fall modes.
The PM increases the amount of ROS that triggers the increase of metalloproteinases that leads to extrinsic aging , which includes skin pigmentation.
The PNX rates after cannulation of the IJV vary between @number@ and @percent@.
The poem can thus further insight into the development of contempt and promote empathy and professionalism in dealing with states such as late-life depression.
The point and counterpoint discussion highlights adaptive vs. maladaptive autophagy.
The point of departure of this Editorial is the fact that we all are engaged in self-rationing in our everyday lives.
The point prevalence of antibiotic use in patients with dementia ranged from @number@ to @percent@.
The Poisoning mortality rate was @percent@.
The polarization of immune cells is critical in controlling the stages of inflammatory response.
The policy actors , including individuals and organizations working within and outside of government , are described.
The policy goal of the study was to expand the discussion on levels of assistance needed in senior transportation.
The Polish adaptation of the TFI proved a useful and fast tool for assessing frailty.
The Polish versions of the Tilburg Frailty Indicator ( TFI ) for frailty assessment and 8-item Morisky Medication Adherence Scale for adherence assessment were used.
The polyamine spermidine is naturally present in human diets , though to a varying amount depending on food type and preparation.
The polycomb group protein BMI1 has been linked to proliferation , senescence , cancer progression and stem cell phenotype.
The polyglutamine expansion destabilizes htt leading to protein misfolding , which in turn triggers neurodegeneration and the disruption of energy metabolism in muscle cells.
The polyglutamine tract is encoded by a trinucleotide repeat in a coding region of the ataxin @number@ gene ( ATXN2 ) .
The polymerization kinetic revealed a rising curve , and materials , when directly photopolymerized , reached a plateau immediately after light exposure.
The polymerization kinetic was recorded for @number@ minutes.
The polymorphisms were also investigated for their association with reported life-long engagement in complex cognitive activity using a retrospective questionnaire.
The polymorphisms were apolipoprotein E ( APOE ) , ( COMT ) , and brain-derived neurotrophic factor ( BDNF ) .
The polypeptide hormone relaxin has been proven to be effective in promoting both the remodeling and regeneration of various tissues , including cardiac muscle.
The POMK catalytic domain shows a typical protein kinase fold consisting of N- and C-lobes.
The PON1 rs662 SNP ( single nucleotide polymorphism ) was associated with serum HDL-c levels in the longevity group.
The pooled data from randomized controlled studies favored person-centered care in reducing agitation , neuropsychiatric symptoms , and depression and improving the quality of life.
The pooled effect from three studies for self-reported function was @number@ in favour of power training ( @percent@ CI @number@ to @number@ ) .
The pooled odds ratio of CI-AKI in the elderly was @number@ ( @percent@ CI @number@.85-3.52 , I ( @number@ ) = 0.34 ) .
The pooled sample comprised of @number@ individuals.
The pooled specificity ( @percent@ CI ) of FIT was @percent@ ( 90-95% ) .
The pools compress the collagen fibers.
The poor bioavailability of resveratrol in humans has been a major concern for translating basic science findings into clinical utility.
The poor clinical outcome of aging in cardiovascular disease is recapitulated on the cellular level.
The poorer optical properties of the eye with older recipient age after DSEK can be attributed to the retained host cornea.
The poorer performance of older Met-allele carriers reflected transposition errors , whereas no genetic effect was found for omissions.
The poorest participants in each frailty category had similar well-being to the most well-off with worse frailty status.
The poorest self-rated health and the highest disability rate were found in the older Vietnamese.
The poor functional status of aging combat-exposed Veterans is of particular concern.
The poorly conserved miR-1202 is downregulated in depression and is negatively correlated with GRM4.
The poor outcomes in this group are due , in part , to underdiagnosis and undertreatment.
The poor state of health in men compared to their female counterparts is well documented.
The popular approach considering SAT mainly as the subject of cosmetic procedures for improving the appearance of body contours should be avoided.
The popularity of cutaneous laser resurfacing has soared in recent years.
The population above @number@ years is a very heterogeneous group though , and age alone might not be the best predictor.
The population aged @number@ years and older is also increasing and is not exempt from the obesity rise.
The population ageing is a challenge for health professionals.
The population aging in Brazil and in the world is a reason for an epidemic inquietude.
The population attempting pregnancy and having babies is ageing.
The population attempting pregnancy and having babies is ageing.
The population attributable fraction of death due to high SAAG was @percent@ ( @percent@ CI @date@ @percent@ ) .
The population-attributable risk proportion was @percent@ for all fractures and @percent@ for hip fractures.
The population average fabric atlas yielded substantially higher errors than the MTP with the CR mapping scheme.
The population-based controls were sampled from the resident registry according to the gender ratio of the EL group.
The population coverage of cancer surveillance has been expanded , and the data quality has been improved.
The population focused on this study were healthy older people who participated in randomized controlled trials that investigated the effectiveness of cognitive-based training.
The population is aging.
The population is aging , and breast cancer incidence increases with age , peaking between the ages of @number@ and @number@
The population is aging , the prevalence of heart failure increases with age , and on average women live longer than men.
The population is aging throughout the world.
The population of adults with Duchenne muscular dystrophy is increasing rapidly.
The population of baby boomers ( age 60-65 ) is rapidly increasing globally.
The population of elderly individuals is increasing worldwide.
The population of elderly patients with von Willebrand Disease ( VWD ) is growing because of the improvement of medical care.
The population of Europe is rapidly aging , which will increase the health effects of future temperatures.
The population of men who can be potentially treated with testosterone supplementation is growing.
The population of older adults is increasing.
The population of older patients with inflammatory bowel disease ( IBD ) continues to grow , partly reflecting the aging global population in general.
The population of older people with ID is growing , but knowledge about their use of healthcare is limited.
The population of patients with osteoporosis and diabetes is increasing as the aging population increases.
The population of the Netherlands is aging , although it is still relatively young in comparison with the population of most other European countries.
The population of the United States and most industrialized nations is undergoing rapid expansion of persons aged @number@ years and older.
The population of the United States and the world is aging rapidly.
The population sample showed a relative satisfaction with their life , as well as a low physical and psychological malaise.
The populations of light-demanding trees that dominate the canopy of central African forests are now aging.
The populations studied are not homogeneous and generate different results.
The population studied is consistent with the Fried model , in which one in five older adults can be labeled as frail.
The population used a mean of eight medications per day ( prescription and nonprescription ) .
The population was a cohort of @number@ older men examined between @number@ and @number@
The population was derived from the REACTION study conducted across China.
The population was drawn from the Metropolit cohort of men born in @number@
The population was predominantly female ( @percent@ ) , White ( @percent@ ) , married ( @percent@ ) , and catholic ( @percent@ ) .
The population was subsequently stratified according to age and use of abciximab.
The Populus species possess great potential for therapeutical applications , especially for their known anti-inflammatory properties.
The porosity was also quantified using the CSLM data and compared to this derived from SEM imaging.
The portability and ease of use would make it a useful additional tool for detecting impaired visual function in infants.
The Portuguese version of the Falls Efficacy Scale was used for measure fear of falling.
The positioning of the eyelid-cheek clinical junction in relation with the low orbital bone rim influences our strategy in choosing the appropriate technique.
The position paper focused on eight quality standards for the management of hip fracture older patients in orthogeriatric model of care.
The positions of wrinkles were compared with the anatomical location of carotid artery bifurcation with the use of Doppler - Duplex Ultrasound.
The positive association observed in men was partially mediated through attained height.
The positive association of TTR with postprandial TG warrants further investigation.
The positive correlation between iron levels and age was most significant in the basal ganglia ( caudate nucleus , putamen and globus pallidus ) .
The positive correlation with uric acid and BUN warrants further studies.
The positive effects , however , were not maintained at 6-month follow-up , but were reduced.
The positive effects of these games have also been demonstrated on physical health ( e.g. improvement of balance and gait ) .
The positive emotion skill-building intervention proved feasible especially in the internet videoconference delivery format.
The positive feedback from participants indicated the feasibility of our tailored nutritional guidance.
The positive influence of childhood intelligence on ' g ' was greater in the younger sample.
The positive influence of PA interventions on sarcopenia has been described previously on many occasions.
The positive perceptions among students in the current study suggest an increased acceptance of sexuality and diversity that should be maintained in university curricula.
The positive predictive value of the single-item criteria in predicting the Fried frailty phenotype ranged from @percent@ to @percent@.
The positive rate of anti-HBs was statistically significant ( χ ( @number@ ) = @number@ P = @number@ ) .
The positive rate of anti-HEV antibody in veterinarian and farm staff-related practitioners was significantly higher than the general population.
The positive rate of hepatitis B indicators and coverage rate of HepB in different population were compared.
The positive relation of HRQoL with physical activity was significantly higher in old-old compared to young-old adults.
The positive relationship between childhood and late-life intelligence decreases with age.
The positive relationship between higher BMD and recreational activities is attenuated with age.
The positive relationship between perceived stress and depressive symptoms was weaker for people who were higher in Conscientiousness than those who were lower in Conscientiousness.
The positive subjects from either method would be provided a further colonoscopy examination for pathological diagnosis.
The positivity of blood cultures and proportions of microorganisms varied by geographical region across mainland China.
The positivity rate of the test in children aged 72-83 months was similar to that referred in healthy adults , irrespective of colonization.
The positivity ratio was also associated with mental health status in the hypothesized direction ; higher positivity ratios were associated with better mental health.
The possibilities of the reverse development of symptoms were statistically proved.
The possibility of a cohort effect for the middle-aged group is discussed.
The possibility of arresting or delaying skin ageing represents a large research area and has a big potential in the cosmetics sector.
The possibility of dementia prevention by cardiovascular risk factors control has not been demonstrated.
The possibility of differences between sexes in lens thickness growth is also analyzed.
The possibility of modulating the follicular pool and the health of follicles during this period to improve fertility is worth exploring.
The possibility of retesting these samples after many years should be guaranteed.
The possibility to identify the moment of switch from a mortality-governing pathway to some other pathways might be useful for testing geroprotective drugs.
The possible adaptive significance of long-term memory for events ontogenetically preceding long-term memory for locations is discussed.
The possible association of vitamin D with depression and global cognitive performance was explored by Poisson regression.
The possible better compliance of this cohort due to high educational status may overestimate the clinical effectiveness of outpatient GEM services.
The possible comorbid condition of VHD and CAD and the factors that influence the comorbidity were examined by covariance structure analysis and multivariate analysis.
The possible contribution of physical and chemical carcinogens associated with environmental pollution and negative lifestyle changes should not be forgotten either.
The possible effects of BET on hObs differentiation were evaluated by real time PCR , western blot and immunofluorescence analysis.
The possible existence of such processes and the data confirming their presence are discussed in this review.
The possible genotoxicity of extremely low frequency magnetic field ( ELF-MF ) exposure is still a controversial topic.
The possible mechanism for antimicrobial resistance and mechanism of action of probiotics are also discussed in detail.
The possible metabolic outcomes of the pharmacological manipulation of sirtuins are also discussed.
The possible modifying effect of the city on correlates of LSA was examined.
The possible molecular mechanisms that lead to an age-related decline in brown adipogenic stem / progenitor cell function include cell-autonomous and external effects.
The possible participation of autophagy in the pathogenic sequence of COPD has been extensively explored.
The possible regulation mechanism of red light was determined to discover how to retard UVA-induced skin photoaging.
The possible role of age as a modifier of PFAS serum trends merits further research.
The possible role of brain natriuretic peptide in the pathophysiology of accelerated malignant hypertension was discussed and a review of the literature was completed.
The possible role of crotonaldehyde-modified DNA in cancer has been suggested.
The possible role of host counter responses and interactions with gastric epithelia and immune cells are also detailed.
The possible role of inflammation , bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically discussed.
The possible role of statins on gallstone disease is discussed.
The possible strengths and limitations of each method are highlighted , which can guide readers when selecting a method based on a given research question.
The posterior border was flanked by white matter bridging the red nucleus and substantia nigra and seen as hypointense on spin-echo magnetic resonance images.
The posterior central gyrus and supplementary motor area during MI were more active in the younger group than in the older group.
The posterior cingulate cortex is a highly connected and metabolically active brain region.
The posterior column , corticospinal tract and spinocerebellar tract showed loss of myelinated fibres and gliosis.
The posterior eye is a complex biomechanical structure.
The posterior probability distributions for model parameters derived using WeLMoS method were inconsistent with the ICRP @number@ default parameters.
The posterior scleral cup of @number@ eyes from @number@ human donors was mounted onto a custom inflation chamber.
The posterior tibial muscle is the key dynamic support of the medial longitudinal arch of the foot.
The posterolateral boundary of the putative cardinal and sacrouterine ligaments coincided with the adventitia surrounding the mesorectum.
The post-feeding profile in children with Prader-Willi syndrome is also peculiar , with a conserved and deeper inhibition of all ghrelin forms.
The post-GWAS era provides an opportunity for cross-phenotype analyses between different complex phenotypes.
The post-hoc results suggest that Mental group improved significantly more than the Control group.
The post-inflammatory hyperpigmentation rate was @percent@ and @percent@ at @number@ and @number@ months post-treatment , respectively.
The postintervention assessment results provided evidence that phonic reading instruction was generally effective in improving reading skills and phonological awareness of children with Down syndrome.
The postmenopausal study group shows significant lower values in the damping ratio ( young @number@ vs. postmenopausal @number@ P < 0.01 ) than young women.
The postoperative ADL score ( focusing on patients ' walking ability ) was significant for those living at home than for those living in facilities.
The postoperative complication rate ( p = @number@ ) was not increased , even for major complications ( p = @number@ ) .
The postoperative pure-tone average was @number@ dB HL ( the best mean threshold was @time@ HL , the worst was @number@ dB HL ) .
The postoperative results were used to define the norm for straylight in pseudophakia.
The postPU is well known to be an initial region of DAT decline and be severely affected throughout the illness.
The postPU , which belongs to the sensorimotor striatum , may be particularly vulnerable to the effects of age in young and middle-aged subjects.
The posttest response rate was @percent@ ( n = @number@ ) .
The post-translational AAR and AAI could significantly induce the density and localization of plaque deposition in brain tissues.
The posttreatment outcome was assessed through B-mode ultrasound , 3-dimensional ( 3D ) topography scanning , and a patient satisfaction survey.
The post-tumor samples did not show any distinct clustering of the gut microbiota between the two diet groups.
The postural tasks selected consisted of static standing , functional reach , functional stability boundary and gait.
The posture was monitored on a force platform.
The posturographic signals of old patients with idiopathic gait disturbance were compared with the control group of similar age and with younger patients.
The potency of these cells promises to change the longer term prognosis for many degenerative conditions currently suffered by our aging population.
The potential application of the insights gleaned from these research findings to anti-inflammation and anti-infection is also discussed.
The potential applications of this engineered chaperone are discussed.
The potential benefits of supplement use in athletes are thus questionable.
The potential cause of disc degeneration has been attributed to aging , genetic factors , mechanical factors and nutrition.
The potential cellular and molecular mechanisms whereby AMSCs restore mucosal immunity in immunosenescence are discussed in this short review.
The potential contributions of age-related sensory and cognitive declines to these stream segregation effects are discussed.
The potential deleterious effects of RBC microparticles in transfused recipients , including hypercoagulability , microcirculation impairment and immunosuppression , are discussed.
The potential effect of obesity on oesophageal peristalsis and the implication of impaired oesophageal clearance in GORD pathogenesis are still to establish.
The potential for DDIs between DAAs and comedication / cART were predicted using @url@
The potential for flavanone-rich foods and drinks to attenuate cognitive decline in aging and the mechanisms that underlie these effects should be investigated.
The potential for identification of a minimal set of objective measures to identify , or at least consider risk for both conditions , is proposed.
The potential for improvements can be directly influenced by the nursing home itself.
The potential for metals to bioaccumulate in aquatic species , such as fish , via trophic level transfer was investigated.
The potential for positron emission tomography ( PET ) to detect neuroinflammation in vivo has sparked a remarkable interest in various disciplines of neuroscience.
The potential for workplaces to become social institutions that contribute to dimensions of successful aging is discussed.
The potential impact of future studies which incorporate risk-stratification into ED disposition decisions cannot be underestimated.
The potential impact of neutralizing antibodies and systemic toxicity were also addressed.
The potential impact of recent research findings in the field on therapeutic treatment strategies for human obesity is also discussed.
The potential implications of F2RL3 methylation for early detection , risk stratification and prevention of lung cancer warrant further exploration.
The potential influence exercise may impact on this relationship is unstudied in aging men.
The potential interaction with RBMS3 needs confirmation.
The potential long-term effects of a higher early protein intake on long-term kidney function needs to be determined.
The potential mechanisms of how this crosstalk proceeds are discussed in detail.
The potential mediating roles of perceived social support and perception of control were also explored.
The potential now exists to delay human aging , whether it is through known classes of small molecules or a plethora of emerging ones.
The potential of anesthetics to induce long-term alterations in brain function , particularly in vulnerable populations , warrants investigation.
The potential of caveolin to overcome barriers to protection with the ultimate hope of clinical translation will be discussed.
The potential of chitosan , chitooligosaccharides and their derivatives in prevention and treatment of age-related dysfunctions is reviewed and discussed in this paper.
The potential of melatonin-based therapeutics for clinical application in stroke patients requires translational research to guide the conduct of clinical trials.
The potential of transcutaneous vagus nerve stimulation ( tVNS ) , a noninvasive alternative to dVNS , to alter memory performance remains unknown.
The potential options for IGF-1 therapy arise as a promising strategy in a wide list of human diseases.
The potential physiological role of AMH and clinical applicability of AMH measurements remain to be determined.
The potential predicting variables were baseline proximal , distal , and total UE-FMA and Action Research Arm Test scores.
The potential predictors may allow occupational therapy practitioners to target those children who will benefit most after home-based constraint-induced therapy.
The potential risk factors for gout and hyperuricemia were analyzed by logistic regression.
The potential risk of increased toxicity in older adults with comorbidities is explored using the data available.
The potential role of brain and cognitive reserve in traumatic brain injury ( TBI ) is reviewed.
The potentials for prevention and treatment are also discussed.
The potential sources of disconnection , however , are unclear.
The potential therapeutic effect of repetitive TMS in restoring or compensating damaged cognitive functions , might become a possible rehabilitation tool in AD patients.
The potential to enhance prognosis of CRC patients by promotion of smoking cessation , embedded in tertiary prevention programs warrants careful evaluation in future investigations.
The potential to ' find home ' was influenced by mediating and facilitating / constraining factors.
The potential usefulness of the CGA in evaluating treatment and follow-up of older patients with CKD is unknown.
The potent induction of GH secretion and the stimulation of appetite are the most intensively studied functions of GHS-R1a.
The potent redox activity of copper is required for sustaining life.
The power training-induced neuromuscular adaptations were associated with increases in isometric muscle strength and partly with increases in fast gait velocity.
The PPAR subfamily includes ligand-dependent transcription factors that consist of three isotypes : PPARα , PPARβ / δ , and PPARγ.
The PPEDA films undergo an alteration during the storage in ambient air , particularly , due to reactions with oxygen.
The PPVs for HPV DNA screening with cytology triage were consistently higher than those for conventional screening.
The p.R47H variant was found in @number@ patients with FTD-S.
The practical as well as theoretical implications of these findings are discussed.
The practical necessity and performance of FMR are illustrated through applications to a longevity analysis of female medflies and a human growth study.
The practical use of our model was illustrated by an application to longitudinal episodic memory outcomes from two cohort studies of aging and AD.
The practice of a physical activity increased in @percent@ among the patients after surgery.
The practice of Generational Dermatology will decrease patient morbidity and bring down the cost of healthcare.
The practice of sports is known to benefit brain functioning , improving memory among other abilities.
The pragmatic concept to constrain microglia through dietary intervention is significant because neuroinflammation and cognitive deficits are co-morbid factors in many chronic inflammatory diseases.
The pragmatic potential of the three postulates was applied to seven proposals using evidence-based meta-analysis mainly from randomized controlled trials.
The pragmatic trial design provides a real-world assessment of the COMPASS care model effectiveness and will facilitate rapid implementation into clinical practice if successful.
The PRC2 signature was shown to be generally stable across cell types.
The PRCs associate with the p16 ( Ink4a ) / Arf locus in young proliferating cells and dissociate from it in senescent cells.
The PREADViSE trial recruited @number@ men , of whom @number@ continued into the cohort study.
The pre-analytical phase , including all the aforementioned issues , should be standardized within a quality assurance program.
The pre- and post-DOAC era cohorts included admissions from @date@ to @date@ and @date@ to @date@ , respectively.
The pre- and post-scenario assessment comprises @number@ questions , exploring the understanding toward basic issues related to LST.
The precautionary savings model predicts that households accumulate wealth to self-insure against unexpected declines in future income and unforeseen expenditures.
The precipitants , course , and outcomes related to these symptoms may be unique from other neuropsychiatric symptoms characteristic of AD.
The precise and detailed anatomical knowledge of the intervertebral foramen of the cervical spine is essential for the diagnosis and management of cervical radiculopathy.
The precise effects of aging on DCs in immunity to infections are not well understood.
The precise extent of aortic wedging , however , and its influence on the surrounding cardiac structures , has not been systematically investigated.
The precise impact of CKD on the development of cognitive impairment is poorly understood.
The precise localisation of the Hbs is within the inner membrane space and associated with inner mitochondrial membrane.
The precise mechanisms by which these phytochemicals differentially affect the AHR and NRF2 system remain largely unknown and warrant future investigation.
The precise mechanisms by which this occurs are not yet understood , but there are some testable hypotheses and already a few direct clues.
The precise mechanisms of antioxidant-mediated longevity are poorly understood.
The precise operational definition of psychosis in dementia lacks consensus , partially owing to incongruence in the various assessment tools used.
The precise pathogenic mechanism remains unknown , and there is currently no effective therapy.
The precise role of age-related muscle anabolic resistance in the progression of sarcopenia and functional decline in older individuals is unclear.
The precise shape of their association , however , has not been established.
The precision of the observers ' judgments across repeated trials , however , was not affected by age.
The precuneus is included in the default mode network , which is deactivated during cognitive tasks.
The predicted clearance can then be used to select a dose to initiate a clinical trial ( pharmacokinetics , safety and efficacy ) in children.
The predicted clearance value was then compared with the observed clearance value in that child.
The predicted complication incidence rate was well matched with the actual complication rate by Hosmer-Lemeshow test.
The predicted evolution of pressure and augmentation index with age followed accurately the curves obtained in a number of large-scale clinical studies.
The predicted fracture patterns matched fairly well with the visually observed experimental cracks.
The predicted new b-blocker equation to peak VO ( @number@ bb ) was @number@ - @number@ × age.
The predicted role of CMJ on interlimb coordination indicates that a fine neuromuscular activation timing is central for both jump and coordinative performances.
The predicted \ "safe distance \ " decreases with age from @number@ mm to @number@ mm in females and @number@ to @number@ mm in males.
The predicted wavelengths and amplitudes of various instability patterns match well with our experimental data.
The prediction equations were validated using double cross-validation.
The prediction model used a support-vector machine learning technique to perform a 10-fold cross-validation analysis.
The prediction model was internally validated using resampling techniques.
The predictions improve on existing fixed percent-weight-loss thresholds.
The predictive ability of CRP was limited ( C-statistic increment @number@ ) .
The predictive ability of the scoring system was quantified by the area under the curve.
The predictive accuracy for progression to dementia was poor.
The predictive ( concurrent ) validities of the adverse health outcomes and healthcare utilization were acceptable ( AUCs : @number@.65-0.83 ) .
The predictive link between systemic 11β-HSD1 activity and progressive brain atrophy and cognitive decline suggests 11β-HSD1 inhibition as a plausible therapy for brain aging.
The predictive positive value of biopsy was @percent@ ( 32 / 130 ) .
The predictive power of such longitudinal models will always be limited by the reproducibility of repeated measures acquired during different sessions.
The predictive validity of the frailty classification was tested against 2-year mortality and 4-year disability.
The predictive validity of the resulting scale for poor cognitive performance was evaluated using logistic regression.
The predictive value exceeded all other biomarkers.
The predictive value of BFH-OSTM was validated in the @number@ hospital-checkup population , which performed better than OSTA.
The predictive value of cognitive functioning at @number@ years old on successful ageing @number@ years later is not established.
The predictive value of RDW for a range of negative health outcomes may in part be due to variants influencing fundamental pathways of aging.
The predictive value test of serum lipoprotein ( a ) on PVT was @number@ and on HCC was @number@
The predictive variables included were : Ht ( @number@ ) / R , sex , and body weight.
The predictor risk variables included demographic and comorbid health risk factors.
The predictors of the place of death were identified using logistic regression analysis.
The predictor variable was having fallen in the @number@ months prior to the operation.
The predilection for the site of fracture at the neck of femur falls into two major subgroups.
The predispositions to either major depression or suicide are thought to depend on genetic risk factors or epigenetic effects.
The predominance of chronic non-communicable diseases and rapid aging of the population nonetheless present significant challenges for public health and the health system.
The predominance of hospital deaths was similar to other Brazilian cities , albeit higher than in other countries.
The predominant assumption is that in higher organisms , shortening telomeres provide a firewall against tumor growth.
The predominant distribution pattern of IPC and IDS and the presence of K7 ( + ) hepatocytes were registered.
The predominant form of the disease in either case is sporadic with uncertain etiology.
The predominant mode of failure was adhesive failure at the ceramic surface.
The preferences of the older adult placed at the center of the care planning process strategically support goal attainment.
The preferred treatment is directed at the underlying disease.
The pregnancy and implantation rates were similar whether the source was infertile women sharing half their oocytes or compensated donors.
The pregnancy became complicated due to oligohydramnios and therefore a caesarean section was carried out in order to preserve the fetus.
The pre-impact lead time of fall ( PLT ) is an important part of the human fall theory.
The preliminary broad search of the literature on the effects of omega-3 fatty acids on normal aging yielded @number@ citations.
The preliminary findings showed that the screening tool was delivered efficiently and targeted clients at potential high risk for residential care placement.
The preliminary result of greater brain activation with increasing age might reflect an attempt to compensate for decreasing episodic memory capacity associated with aging.
The preliminary results from three patients showed an abnormal slowness of latencies , even in the gap condition expected to promote automatic and reflex saccades.
The preliminary results indicate a promising therapeutic regime for dry AMD and perhaps for other types of retinopathies as well.
The «premature ageing» hypothesis proposes that the brain areas of alcoholics undergo deterioration similar to that observed in old age.
The pre-mRNA alternative splicing of hTERT at the post-transcriptional level is one of the mechanisms for the regulation of telomerase activity.
The prenatal environment significantly contributes to the width of the neonatal line , influencing the pace of reaching post-delivery homeostasis by the newborn's organism.
The preoperative mean pure-tone average threshold for @number@ Hz , @number@ Hz , @number@ Hz , and @number@ Hz was @number@ dB HL.
The preoperative MPOD prediction formula was MPOD = @number@ - @number@ × nuclear color score.
The preparation is a very important phase which requires a thorough knowledge of cosmetics.
The PrepMan Ultra sample preparation reagent yielded the best results among the four DNA extraction methods.
The pre / post distribution for hyperphosphorylated tau was @number@.9% / 30.7% , and for misfolded tau @number@.3% / 19.3%.
The pre-processed signals were then used to calculate @number@ time , frequency , and time-frequency domain features for each independent signal.
The prerequisite to investigate causal risk patterns including biologic , genetic and environmental factors across different NCDs are well characterized cohorts with associated biobanks.
The prescribing of long-acting calcium channel blocker drugs in a single dose is the most recommended.
The prescription of insulin is a dynamic process , and the insulin regimen should be adjusted based on individual response.
The presence and location of resident pancreatic β-cell progenitors is controversial.
The presence and number of CMBs were graded using Brain Observer Microbleed Scale on susceptibility-weighted images.
The presence and the degree of STDE were analyzed in relation to regional CBF in nocturnal blood pressure dippers / non-dippers.
The presence of a chronic health condition was not related to chronological age.
The presence of active brown adipose tissue in adult humans has been recognized in general physiology only since @number@
The presence of additive interactions between comorbidity and less than positive attitudes on falling in low QoL was clearly suggested.
The presence of a family member increases nonverbal pain expressiveness whereas the presence of a stranger results in decreased self-reported pain unpleasantness.
The presence of age-related reference intervals.
The presence of AGEs and CEL was also determined by western blotting and immuno-histochemical analysis.
The presence of a mutation was associated with a lower grey matter volume ( P = @number@ ) , even in presymptomatic subjects.
The presence of an abrupt weight decline was not associated with MCI / dementia.
The presence of an extended GRD , however , seemed to potentiate the hnRNP D silencer activity of isoforms p42 and p45.
The presence of atherosclerosis in ancient human beings suggested that aging and genetic predisposition might be essential risk factors for atherosclerosis.
The presence of atrial fibrillation was @percent@ in patients with LVRR and @percent@ in those without ( p = @number@ ) .
The presence of brown adipose tissue is associated with cold-induced nonshivering thermogenesis , and the tissue may be a major organ for glucose disposal.
The presence of CAA in patients without Alzheimer's disease may indicate a distinct cerebrovascular condition.
The presence of cardiopulmonary disease was negatively associated with walking speed as well , with the highest effect size for the 6-min walking test.
The presence of cerebral amyloid angiopathy may be an important source of cognitive decline in aging.
The presence of cerebral microbleeds seems to be a potential biomarker.
The presence of cerebral white matter lesions ( WMLs ) is a radiological marker of sub-clinical ischemic brain damage.
The presence of certain Bifidobacterium groups was associated with significantly higher numbers of other Bifidobacterium species / subspecies.
The presence of chronic low-grade inflammation did not affect post-infection mortality , body weight loss and tissue mass decreases.
The presence of coronary heart disease and alcohol consumption in this population may confound this association.
The presence of cortical amyloid pathology , as assessed using AV45-PET , did not significantly interact with the observed associations.
The presence of delayed neurologic deficit was also detected.
The presence of diabetes and compliance with standards of care were estimated using appropriate algorithms.
The presence of diabetes and statin use was documented.
The presence of diabetes mellitus was also a significant predictor of patient awareness of cataract ( odds ratio , @number@ ) .
The presence of diabetes mellitus was associated with lower likelihood of SNF admission ( AOR = @number@ @percent@ CI = @number@.73-0.99 ) .
The presence of disc degeneration , spinal stenosis , and disc herniation was evaluated.
The presence of d-isomers is thought to result from the racemization of Asp residues in the crystallins during aging.
The presence of double mutations increases the risk for symptomatic HCM with no change in severity , as determined in this study subset.
The presence of drusen in the extramacular regions ( extramacular drusen score ) , pigmentary abnormalities , and disease staging were also evaluated.
The presence of dysfunctional sleep-related beliefs and attitudes at bedtime in asymptomatic , depressive , and anxious seniors was thus compared.
The presence of early active plaques rapidly declined with disease duration.
The presence of either a large RV midcavity diameter or tricuspid valve tethering area was predictive of adverse outcome at @number@ year after tricuspid annuloplasty.
The presence of end-stage pathology in cognitively intact persons would support the hypothesis that pathological markers are epiphenomena.
The presence of facial aesthetic unit separation results in a less youthful appearance.
The presence of fatty liver was determined at each examination by ultrasound.
The presence of fever and rash may be associated with renal recovery.
The presence of genomic instability in the ageing process and in most chronic diseases , demands further investigation on this issue.
The presence of HPC in CHC was examined in relation to histological and virological parameters and patient age.
The presence of HPC was evaluated by immunohistochemical expression of keratin @number@ ( K7 ) .
The presence of HS-Aging pathology correlates with significant cognitive impairment which is often misdiagnosed as AD clinically.
The presence of HV was assessed visually using a validated examination.
The presence of hyperlipidemia at baseline ( HR down to @number@ p < 0.05 ) was associated with better prognosis.
The presence of hypertensive participants did not affect the results.
The presence of impaired thermoregulatory and fluid balance responses to exercise in older individuals is well established.
The presence of irritation ( @number@ additional hours ) was associated with the greatest number of additional hours of active help.
The presence of isopeptide bonds impairs protein structure / function.
The presence of isopeptide bonds impairs protein structure / function and can trigger autoimmune responses.
The presence of joint disorders , especially RA , at midlife seems to be associated with a worse cognitive status later in life.
The presence of low cognitive performance was negatively associated with walking speed , with the highest effect size for the 4-m walking test.
The presence of L-PVSs was also associated with a steeper decline in information processing speed and more than quadrupled the risk of vascular dementia.
The presence of lumbar disc herniation was associated significantly with decrease in signal intensity of intervertebral disc and posterior disc protrusion in the cervical spine.
The presence of lymphatic vessels was confirmed in the VF of elderly subjects.
The presence of major depressive symptoms was associated with moderate or greater severity alcohol symptoms ( AOR = @number@ @number@.1-3.0 ) .
The presence of metastases , high leukocyte count , and platin-based chemotherapy increased the risk up to three-fold.
The presence of mild cognitive impairment was determined through an expert consensus process using Level @number@ criteria from the Movement Disorder Society.
The presence of multiple cell clones with distinct genotypes in the same individual is referred to as ' somatic mosaicism'.
The presence of multiple risk genotypes was associated with a trend for additive risk for HS-Aging pathology.
The presence of normal number of functional mitochondria is also crucial for proper implantation and pregnancy maintaining.
The presence of @number@ additional small noncoding RNAs was also verified by TaqMan qPCR in productively infected fibroblasts and ARPE19 cells.
The presence of olfactory symptoms was obtained via case notes and clinical interview.
The presence of OSA in stroke patients is associated with poor outcome.
The presence of other co-morbidities , age-related changes in pharmacokinetics and possible risk of drug-drug interaction needs to be considered before commencement of medication.
The presence of other degenerative changes , such as disk degeneration , spondylolisthesis , and facet osteoarthritis , at affected levels also was noted.
The presence of pneumococcal antigen in urine was detected by BinaxNOW® S. pneumoniae kit.
The presence of previous bladder cancer and Grade @number@ were independent predictors for tumor recurrence ; however , patients ' age was not selected.
The presence of proinflammatory monocytes / macrophages ( CD14 + CD16 + ) has been documented in conditions of inflammation , such as atherosclerosis.
The presence of PVN and lesion volume ≥2 mL are independent predictors of sensory extinction in acute stroke.
The presence of RBC autoantibodies has never been extensively investigated in HS.
The presence of risk in the ability to discover and organize visual logical stimuli is explored.
The presence of senile purpura requires continuous follow-up since drug-induced purpura may cause plaque function alterations.
The presence of several RBC antigens , expressed on microparticles , has been demonstrated.
The presence of steroidogenetic enzymes in muscle tissue indicates that the elevated postmenopausal steroid levels in skeletal muscle are because of local steroidogenesis.
The presence of such pattern confirms observations from experimental studies that regulation of life span involves genes responsible for stress resistance.
The presence of the APOE ε4 allele correlated with lower total selenium levels in the temporal cortex and a higher concentration of soluble selenium.
The presence of the GLUT8 transporter was established and found to be attenuated by ( R , R' ) -MNF.
The presence of the mutation in the Japanese population extends the geographic region for involvement of the VCP gene in sporadic ALS to East Asia.
The presence of these abnormalities usually disrupts normal blood flow and is associated with the development of prominent collateral circulation.
The presence of these alleles identifies patients of high risk and requirement of insulin therapy.
The presence of these isoforms enhances the complexity of the astrocyte cytoskeleton and is likely to underlie subtype specific functions.
The presence of the ε4 allele has been associated with lower levels of apoE in both serum and brain tissues of normal and AD subjects.
The presence of ubiquitin deposits within drusen was remarkable , but diffuse ubiquitin aggregates between the retinal pigment epithelium and Bruch membrane were also noticed.
The presence of wild-type protein also downshifted the temperature range of W42Q aggregation.
The presence of WMH was assessed using MR images.
The presence or absence of pain may be an unreliable indicator of c-spine fracture in an aging population.
The presence or absence of rod-shaped microglia was scored on IBA1 immunohistochemically stained slides for the hippocampus and cortex.
The presence or higher levels of serum antibodies against the genitourinary pathogens studied were not consistently associated with PCa.
The present analyses incorporate @number@ cases of autopsy-proven hippocampal sclerosis of ageing and @number@ controls.
The present analysis includes @number@ individuals ( mean age @number@ ± @number@ SD years ) followed up over @number@ years.
The present analysis utilized a European database to focus on the elderly.
The present article aims to define pelvic health and to compare the differences in perspective on this issue between the medical and women.
The present article aims to evaluate the outcomes of enteral nutrition for people with advanced dementia.
The present article aims to highlight the relative contribution of platelet oxidative stress as a key target of frailty in elderly people with CVD.
The present article draws attention to developmental trajectories of self-continuity , defined as perceived associations of one's present self with past and future selves.
The present article focuses on the social explanations , i.e. explanations that identify causes of loneliness in the structure of modern society.
The present article is aimed at reviewing scientific studies that show the protective effects of flavonoid intake against mild cognitive impairment and dementia.
The present article is a review of the development of biomarkers for these purposes specifically as they pertain to degenerative musculoskeletal conditions.
The present article reports the main results of the Task Force discussions to generate a new paradigm.
The present article reviews the literature , and introduces contemporary perspectives and management of testosterone deficiency.
The presentation of an ADR in older adults is often atypical , which further complicates its recognition.
The presentation of mitochondrial cardiomyopathy includes hypertrophic , dilated and left ventricular noncompaction , but the molecular mechanisms involved in cardiac impairment are unknown.
The present candidate gene approach investigates the relationship between single nucleotide polymorphisms ( SNPs ) in genes encoding key CPC components and breast cancer risk.
The present case is reported because of its rarity.
The present case is reported due to its rarity.
The present cognitive rehabilitation included physical therapy , occupational therapy and speech therapy for 1-2 h once or twice a week.
The present commentary highlights selected scientific opportunities specific to the study of renal development , physiology , and cell biology.
The present comparison should be considered in the domain of a case-study format.
The present cross-sectional study investigated the development of phonological recoding in beginning readers of Dutch , using a proofreading task with pseudohomophones and control misspellings.
The present data expand our knowledge of human muscle mass regulation during short-term immobilization.
The present data illustrated that younger subjects suffering from heart disease showed characteristics of people of higher age ( higher physiological age ) .
The present data indicate that LD absorption is consistent in PD patients , regardless of age.
The present data may provide a rationale to derive recommendations for the starting age of screening in women with affected family members.
The present data provide a global perspective on expression of DNA repair genes that may contribute to cataract pathogenesis.
The present data suggest that annual health examination data does not predict longevity , but that HRV does.
The present data suggest that BM-A play a supporting role in the hematopoietic niche and directly sustain HSC survival.
The presented data may be used as reference values for BDI scores of healthy Polish men in subsequent age categories.
The presented data suggest that the ependymal region is more likely to be reminiscent of a low-grade ependymoma.
The presented method allows good visualization of volume relation between gender groups.
The presented multi-stakeholder approach is generally recommended for future development of health promotion interventions.
The presented nanocomposite consists of AA , nano-hydroxyapatite ( nHAp ) and carboxymethyl cellulose ( CMC ) .
The presented protein-interaction network is relevant to the discoveries of the mechanisms of tumorigenesis , aging , and neurodegeneration.
The presented simulations clearly depict the cone of uncertainty as a function of the underlying diffusion profile.
The presented study demonstrates that the radial head is a skeletal site where different age- and sex-related changes of the bone structure become manifest.
The presented technique , on the other hand , is versatile and easy to use , as it follows general geometric principles.
The presented work is a proof of concept of knowledge extraction using the eServices platform information.
The present evidence suggests that the loss of lean tissue in the elderly is exacerbated by low dietary protein intake.
The present experiment aimed to explore the interindividual variability in chemosensory abilities among the elderly population.
The present experiment applied different cueing conditions that measured involuntary orienting , voluntary orienting , and involuntary and voluntary orienting in combination in older adults.
The present experiment examined adult age differences in the production and monitoring of responses in dual-list free recall.
The present experiment examined whether arousal would enhance younger and older adults ' within-item and between-item memory binding.
The present experiment investigated electrophysiological correlates of processing faces of younger and older individuals.
The present feasibility study investigated a virtual online caregiver support group to bring the support group into the home.
The present findings are consistent with SAVI's predictions and advance understanding age differences in the time course relating everyday stressors to emotional responses.
The present findings are of major value for further clinical studies carried out using Orbitrap MS in order to correlate gangliosides with CNS disorders.
The present findings confirm recent studies reporting semantic memory impairment in MCI.
The present findings could have important implications for the interpretation of dual-task performance in both clinical and research settings.
The present findings demonstrate that QBI model is suitable for studying WM tract degeneration in population-level clinical studies.
The present findings depict the potential of FSH receptor-mediated lipodystrophy of adipose tissues in aging.
The present findings emphasize the potential utility of endurance training in increasing the complex variability of HR in middle-aged women.
The present findings highlight the potential of wearable sensor technology for in-home assessment of frailty status.
The present findings may assist public health authorities to implement policies of vitamin D supplementation among older adults at risk for this condition.
The present findings may be helpful when developing immunotherapy for the prevention of CAD.
The present findings point to a complex relationship between younger and older adults ' visual attention and emotional reactions.
The present findings provide evidence of a significant reduction in hospital admissions for IHD in Taiwan following smoking bans.
The present findings provide evidence that p.T96K is associated with FTD-S and that p.L211P may contribute to its pathogenic effect.
The present findings represent the first in vivo report of decreased availability of mGluR5 in bvFTD.
The present findings seem to indicate that the topical application of BAs may represent a suitable treatment option for selected features of skin photoaging.
The present findings suggest that acute caffeine intake enhances WM-related brain activation as well as functional connectivity of blood oxygen level-dependent fMRI in elderly individuals.
The present findings suggest that cortisol output during fMRI should be considered as confounder and integrated in analyzing developmental changes in brain activation during adolescence.
The present findings suggest that DA-induced impairment of autophagy underlies the parkinsonism in HD patients.
The present findings support the hypothesis that alterations in transport of glutamate , and more particular via GLT-1 , may be involved in AD pathogenesis.
The present findings support the use of time intervals and total scores on tasks of verbal fluency in clinical settings and for research purposes.
The present findings will help guide future studies in evaluating geriatrics among hematology / oncology fellows across institutions.
The present fMRI study investigates the effect of age on the spatial frequency processing in scenes.
The present functional magnetic resonance imaging ( fMRI ) study investigated developmental differences in functional connectivity associated with true and false memory retrieval.
The present functional magnetic resonance imaging study investigated whether these findings extend to subsequent memory effects associated with successful encoding of item-context information.
The present implementation should be reappraised , because the present expenditure did not move closer to the objective budget.
The present investigation reveals that contrary to the prevailing views , even young children are able to tell strategic lies in some contexts.
The present investigation therefore sought to preliminarily characterize MQC pathways in muscle of old gastric cancer patients with cachexia.
The present in vitro study was designed to test the hypothesis that α7 nAChR activity decreases when endogenous production of KYNA increases.
The present legal definition of the term research creates problems with what can be considered for ethical vetting by the Research Ethical Review Board.
The present meta-analysis focuses on the following questions : Does prospective memory decline with aging ?
The present meta-analysis integrates the results from @number@ empirical studies on differences between caregiving spouses , adult children , and children-in-law.
The present meta-analysis investigated whether event-based prospective memory ( PM ) age effects differ by task order specificity.
The present meta-analysis synthesized the treatment effect sizes ( ES ) of BT relative to comparison conditions , and examined moderators of treatment.
The present paper addresses this question by investigating the degree to which health effects depend on the development of a shared sense of group identification.
The present paper briefly reviews the advantages and disadvantages of autografts , allografts and BSs for bone reconstruction.
The present paper confirms our hypothesis that live-in caregivers perceive a greater burden than nonlive-in , and this difference increases further after @number@ months.
The present paper describes a theoretically driven community-based project designed to increase volunteer participation in serving Meals on Wheels ( MOW ) clients.
The present paper provides information of the institutional manager's perception on early onset aging and service preparation for this population.
The present paper reviews the definitions and techniques used to measure sarcopenia , as well as the health outcomes of sarcopenic obesity.
The present post-hoc study assessed relationships between age , body image , and emotional distress in women facing breast cancer surgery.
The present prospective cohort study investigated the association between dietary patterns and incident functional disability.
The present randomized controlled trial aims to analyze the effects of a dancing program on the performance on a motor-cognitive dual task.
The present report describes a case in which polydioxanone threads were used to lift the lower third of a patient's face.
The present research examined stressful life events and personality development across middle adulthood.
The present research investigates conditions which might contribute to older adults ' propensity to perform planned intentions under inappropriate conditions.
The present research investigates how these levels combine , and whether the paradox of well-being persists across different economic contexts.
The present results also suggest that these pathological changes in the VPM / VPL are likely a result of lysosomal dysfunction.
The present results indicated a correlation between the individual responsiveness of HSPCs to ionizing irradiation , especially to low dose irradiation , and aging.
The present results indicate that mild oxidative stress maintained throughout culturing regulates APP metabolism / processing in SK-N-MC human neuroblastoma cells.
The present results indicate that the monkey suffers from a kind of progeria that is not necessarily typical to human progeroid syndromes.
The present results indicate the importance of educating students with regard to the unique challenges such work poses.
The present results obtained by NIRS are consistent with the valence asymmetry hypothesis.
The present results provide evidence of a mechanism able to increase PKG-I protein content in contractile cells.
The present results provide initial insights into the behavioral and neural consequences of instructed attention and emotional distraction during WM encoding.
The present results reported the prevalence and associated risk factors of E. granulosus in yaks , Tibetan pigs and native Tibetans.
The present results stress the importance of parahippocampal atrophy as an early biomarker of AD.
The present results suggest a link between adherence to the Dietary Guidelines and favourable vascular health.
The present results suggest that aging is an important factor related to decline in BDNF level.
The present results suggest that uPAR plays a pivotal role in the development of adipose tissue through PI3K / Akt pathway.
The present results support the notion that non-demented PD patients may be capable of acquiring comparable semantic skill to those of the control group.
The present results support the notion that SK channels may offer a promising new therapeutic target in the treatment of AF.
The present review aimed to assess the effectiveness and acceptability of Choto-san in the treatment of adults with cognitive impairment.
The present review article highlights key clinical and research issues in the emerging field of geriatric epilepsy.
The present review attempts to summarize the current knowledge of lncRNA expression patterns and mechanisms in prostate cancer , which contribute to carcinogenesis.
The present review discusses mechanisms involved in muscle atrophy following disuse and during recovery and emphasises the effect of age in these mechanisms.
The present review evaluates the published literature on the prevalence and significance of anaemia in COPD.
The present review examines the enduring effect of exposure to LPS and poly ( I : C ) during the pubertal period.
The present review explores the accelerated aging hypothesis of schizophrenia by comparing changes in BDNF expression in schizophrenia with aging-associated changes.
The present review focuses on longitudinal studies with repeated cognitive assessments.
The present review focuses on some of these less studied and emerging functions of mammalian caspases.
The present review focuses on the coagulation system and CVD from the perspective of testosterone.
The present review focuses on the metabolism of n-3 PUFAs in the brain , including their accumulation and turnover.
The present review focuses on the neuroprotective actions of DR as demonstrated by accumulating experimental and encouraging albeit still limited clinical and epidemiological data.
The present review highlights some of the current developments and future prospects of biotechnological intervention in this important medicinal plant.
The present review includes pre-clinical , translational and clinical research that characterizes ALD and NAFLD.
The present review outlines current knowledge concerning possible pathways , which might be involved in the molecular pathogenesis of sarcopenic obesity.
The present review points out the role of oxidative stress in aging and the potential therapeutic targets of modern antioxidant therapies.
The present review provides a brief summary and update of the relevant literature , summarizing screening tools and interventions to prevent falls and fractures.
The present review provides an updated analysis of the normal and impaired BBB / BSCB , focusing on the ALS-altered barrier.
The present review provides an update on the current knowledge regarding the association of gender and obesity with stroke prevalence and outcome.
The present review provides the scientific foundation of the practice guide.
The present review reports data related to the possible interactive effects of Klotho and FGF23 on the prognosis of renal and CV diseases.
The present review successively addresses these different issues.
The present review summarizes the available evidence in support of physical activity as a remedy against physical frailty and sarcopenia.
The present review summarizes the evidence for synaptic activity-modulated Aβ levels and the mechanisms underlying this regulation.
The present review summarizes the knowledge about a protein-interaction network , which includes proteins with significant functions in the mechanisms of aging and age-related diseases.
The present review summarizes the molecular and clinical aspects of FOXO transcription factor.
The present studies address mechanisms mediating the role of Cbp in diabetes by inhibiting hypothalamic Cbp using a Cre-lox strategy.
The present studies seek to understand the conditions contributing to older adults ' ability to suppress memories voluntarily.
The present studies , using the same model , aimed to demonstrate that dermal fibroblasts influence skin pigmentation up to the macroscopic level.
The present study adapts existing clinical and preclinical indices of frailty to the Fischer ( F344 ) rat.
The present study addresses the need for improved , efficient and feasible continuing pain education through the use of an assessment training video.
The present study adds to the growing literature documenting vital changes in the complexity of emotional experience over the life span.
The present study aimed at comparing the voice characteristics in sustained phonations of PD patients with an age-matched control group.
The present study aimed at describing the effect of aging on LA properties in a large cohort of subjects without structural heart disease.
The present study aimed to characterize profiles of residual decline in late life cognition.
The present study aimed to clarify effects of ELF-EMF on wound healing and molecular mechanisms involved , using a scratch in vitro model.
The present study aimed to contribute to the discussion about the relation between motor coordination and executive functions in preschool children.
The present study aimed to describe the nutritional status and clinical correlates for malnutrition risk in the older people.
The present study aimed to determine the effects of WBV training on HRQoL in elderly women.
The present study aimed to determine the reliability of a series of selected anthropometric measurements in young male and female gymnasts.
The present study aimed to determine whether this capacity is compromised by effects of aging.
The present study aimed to establish normative data for this test in the elderly French-Quebec population.
The present study aimed to evaluate CHCHD2 and CHCHD10 coding variants in Italian patients with PD.
The present study aimed to evaluate the prevalence of sarcopenia and its associative clinical characteristics in Taiwan.
The present study aimed to evaluate these notions while controlling for confounders that may bias towards focalization.
The present study aimed to evaluate whether ginsenoside-Rg5 had any marked cytotoxic , apoptotic or DNA-damaging effects in human cervical cancer cells.
The present study aimed to examine longevity in relation to smoking , overweight and physical fitness.
The present study aimed to explore the potential therapeutic effect and pro-angiogenic mechanism of BPC @number@
The present study aimed to fill this gap.
The present study aimed to find gender differences for arterial stiffness and arterial aging in smokers.
The present study aimed to further explore the fun culture in these communities and to discover its unique qualities.
The present study aimed to identify brain piRNAs across transcriptome that are associated with Alzheimer's disease ( AD ) .
The present study aimed to investigate the effect of loneliness and depression on total as well as specific cognitive domains in cognitively normal male subjects.
The present study aimed to investigate the epidemiology of cough in a community elderly population , particularly in relation with their comorbidity.
The present study aimed to investigate the interplay between psychache and resilience amongst aging HS.
The present study aimed to reveal the duration of obstacle visibility necessary for appropriate visuomotor control during obstacle avoidance in healthy older adults.
The present study aimed to systematically review the literature to assess whether recommendations for zinc intake could be made according to genotype.
The present study aims to assess the relationship between Met S and its components and cognitive functioning in a cohort of elderly non-demented community residents.
The present study aims to clarify such interaction in terms of body movements during daily face-to-face communication in real organizations of more than @number@ people.
The present study aims to evaluate the mutations in mtDNA from dentin and pulp and their relation with age.
The present study aims to examine the unique contribution of food insufficiency in childhood to dementia in old age.
The present study aims to identify potential differences in underlying cognitive processes that may explain inter-individual variability in driving performance.
The present study aims to investigate the validity of an unstructured neuropsychological assessment protocol for this population and develop cutoff values for clinical use.
The present study also demonstrated that the highest sensitivity and specificity are achieved with pairs of miRNAs whose concentrations in plasma are highly correlated.
The present study also demonstrates that miR-128 inhibition in monocytes from AD patients improves Aβ ( 1-42 ) degradation.
The present study also investigates the effect of dihydrotestosterone ( DHT ) treatment ( @number@ mg / kg ) on AD mice.
The present study also points out a way to propagate hSKPs in vitro so as to fulfill their promises in regenerative medicine.
The present study also suggests that unforgiveness has a prospective , but not reciprocal , association with self-reported physical health.
The present study analysed sperm samples of @number@ donors.
The present study analyzes the influence of social networks in the relationship between loneliness and depression in the older adult population in Spain.
The present study assessed performance in @number@ participants in order to identify the ages at which mature performance was reached across differing attention subcomponents.
The present study assessed this possibility in @number@ healthy elderly subjects drawn from the Three-City cohort.
The present study assessed whether age deficits in episodic memory were affected by stimulus characteristics , specifically age of acquisition ( AoA ) .
The present study assessed whether the decline in the efficacy of pain inhibition processes is associated with decreased cognitive inhibition in older persons.
The present study assesses the respective roles of inhibition , age , working memory ( WM ) and response speed.
The present study attempted to examine the relationships between family support , negative interaction , and psychological well-being in older Thai parents.
The present study attempts to uncover this paradoxical association between UA and cognitive impairment in elderly.
The present study can assist understanding the changes in alcohol intake among older adults throughout time and the ageing process.
The present study compared averaged ERP peak and single trial time-frequency ( TF ) data analysis.
The present study compared combined locomotor and cognitive functioning during different phases of stair descent between healthy young and older individuals.
The present study compared how varying task priorities affected young and older adults ' language production.
The present study compared individuals with AD ( N = 240 ) or FTD ( N = 13 ) .
The present study compared the intra-striatal injection of @number@ U with that of @number@ U of collagenase in inducing severe ISH in rats.
The present study compared the performance of forward , backward , and branch and bound feature selection algorithms when applied to electroencephalography and electromyography data.
The present study complements our previous work.
The present study concerns the relation of mental and bodily characteristics to one another during ageing.
The present study concludes that the aged population exhibited a strong increasing future trend for septicemia-related ED visit rates.
The present study contributes to TA-research by validating TA for multiple , differently experienced observers using a collection of modern forensic skeletal cases.
The present study defines muscle fiber type-specific satellite cell content in human skeletal muscle tissue over the entire lifespan.
The present study demonstrated that 25 ( OH ) D concentrations were non-linearly associated with immediate word recall in mid-life.
The present study demonstrated that the SI volume in PD differs depending on cognitive status and is significantly correlated with cognitive performance.
The present study demonstrates in vivo the early functional disruption of nonmotor frontostriatal circuits in PD.
The present study demonstrates that intake of NSAID decreased interstitial PGE₂ and abolished the exercise-induced adaptive increase in collagen synthesis in human tendons.
The present study demonstrates that the effect of APOE E4 on cognitive function depends on age and education.
The present study demonstrates that under definite conditions zinc ions are able to inhibit the ATPase activity of neuron-specific KIF5A ( kinesin-1 ) .
The present study describes a case of fatal sepsis in a patient with systemic lupus erythematosus.
The present study determines whether age effects on associative learning are independent of other cognitive processes involved in PAL.
The present study documented that the HUGE equation had and acceptable performance for screening CKD in elderly Argentine patients.
The present study employed a cross-sectional design using a self-administrative structured questionnaire that was completed by the respondents in @date@ .
The present study employed an Internet-based intervention to increase walking in @number@ sedentary adults over @number@ years of age.
The present study evaluated handgrip strength as independent predictor of cognitive decline.
The present study evaluated perceptions of old age and aging among new CCRC residents and their adult children.
The present study evaluated the influence of aging on blood and plasma viscosity in a group of subjects followed for @number@ years.
The present study evaluated the validity , sensitivity and reliability of the Edmonton Functional Assessment Tool ( EFAT2 ) within a UK palliative care setting.
The present study evaluated whether certain serum parameters predict CD.
The present study evaluated whether vascular and inflammatory markers influence the relationship between BMI and white matter in healthy aging.
The present study evaluates the effect of aging on level- and layer-specific LV longitudinal strain in subjects without structural heart disease.
The present study examined 7- to 11-month-old infants ' anticipatory and reactive reaching for temporarily occluded objects.
The present study examined age and cultural differences in cognitive and affective components of subjective well-being.
The present study examined age dedifferentiation using a structural equation model that controlled for ability differentiation , along with linear and quadratic effects of age.
The present study examined age-group ( younger vs. older adults ) differences in how alcohol use influenced next-day tiredness during daily life.
The present study examined age-related differences in multisensory integration and the role of attention in age-related differences in multisensory integration.
The present study examined developmental differences in event-related potentials between second graders and adults in arithmetic.
The present study examined how younger and older adults choose to selectively remember important information.
The present study examined performances on the MoCA among @number@ non-clinical older adults ( ages 51-85 ) enrolled in a prospective study of cognitive aging.
The present study examined the association between mitochondrial DNA ( mtDNA ) copy number and telomere length in a sample of medically healthy adults.
The present study examined the contribution of quality of that information to episodic FOK judgments.
The present study examined the effect of aging on the detection and discrimination of contours embedded in a dense field of distractors.
The present study examined the effects of seven years of rocket attacks fired toward the south of Israel on adult participants of different ages.
The present study examined the hypothesis that PPARβ / δ promotes HRAS-induced senescence resulting in suppression of tumorigenesis.
The present study examined the mechanism of induction of inflammatory mediators at the transcriptional level in human differentiated neuroprogenitor cells ( NPCs ) .
The present study examined the prospective association between symptom-limited maximal oxygen consumption ( VO2max ) and longitudinal performance on a comprehensive neuropsychological battery.
The present study examined the relationship between executive function ( EF ) and fine motor control in young and older healthy adults.
The present study examined the relationship between lifestyle activities and episodic memory in younger and older adults.
The present study examined the relationship between weight and depressive symptoms over time in older adults in South Korea.
The present study examined the relationship in the eye corner.
The present study examined the reliability and validity of individualized satisfaction measurement using the ADOC.
The present study examined the role of controlled attention in age differences in event-based prospective memory performance across adolescence.
The present study examined these possible negative effects using a dyadic perspective.
The present study examined to what extent cerebral hemodynamics are improved when training is sustained throughout the adult lifespan.
The present study examined whether people become more susceptible to capture by salient objects as they age.
The present study examined whether prolonged contact of mineralized dentin with recently commercialized versions of these materials adversely affects dentin collagen matrix integrity.
The present study examined whether subjective age is associated with memory level and changes , as indexed by measures of immediate and delayed recall.
The present study examined whether there are age-related differences in the ability to accurately monitor forgetting.
The present study examined whether this age-related pattern differs between educational groups.
The present study examined whether this age-specific influence of cortisol on behavioral and brain activation levels also applies to adolescence.
The present study examines age differences in the memory benefits from group-referncing.
The present study examines potential differences in the types of everyday functional limitations present in these @number@ dementias.
The present study examines relationships between host factors ( including age , comorbidity , deprivation , and systemic inflammation ) and survival in CRC.
The present study examines responses of Drosophila reared on AR-supplemented food to crowding , thermal or oxidative stresses.
The present study examines source memory for actions ( e.g. , placing items in a suitcase ) .
The present study examines the direction of influence between aerobic endurance and lower body strength over time in Italian sedentary older adults.
The present study examines the possibility that the visuo-perceptual priming effect is spared in AD.
The present study examines the prediction that emotion can facilitate short-term memory.
The present study examines the reliability of age progressions of the same individuals created by different artists.
The present study examines whether subjective age is associated with change in sleep difficulties across middle adulthood and old age.
The present study examines whether there are secular trends in body weight in old age among three birth cohorts.
The present study examines whether the relationship between memory complaints and memory performance is better assessed by analyzing the mutual development.
The present study explored multi-scale entropy ( MSE ) analysis to investigate the entropy of resting state fMRI signals across multiple time scales.
The present study explored own-age biases in deception detection , investigating whether individuals were more likely to trust those in their own-age group.
The present study explored the identity-cognition association further by investigating the impact of a group decision-making intervention on cognition.
The present study explored the impact of VDR rs2228570 on survival and health of oldest old individuals ( > @number@ years ) .
The present study explored the interaction of aldosterone and DOCA as well as the moderately selective mineralocorticoid receptor antagonist spironolactone on klotho expression.
The present study explored whether older adults have a similar dependency between verbal and spatial information.
The present study explores patterns of parity and disparity in the effect of filial responsibility on health-related evaluations and caregiving decisions.
The present study explores Winick's research in the context of an ageing population and older adult mental health services.
The present study extended this examination systematically to other prefrontal white matter regions.
The present study focused on Alzheimer disease , a condition commonly associated with cognitive declines detrimental to daily life activities such as crossing the street.
The present study focused on evaluating additional neurodegeneration-related proteins , including α-synuclein and TDP-43 , and p62-positive deposits.
The present study focuses on the quantitative changes of the capillary bed in aging human skin.
The present study found that such measures detected early disease changes in MCI as well as further minicolumn thinning and disruption in AD.
The present study found that tripchlorolide ( T Epigenetic modulation is found to get involved in multiple neurobehavioral processes.
The present study further investigated whether young and older adults break gaze anchoring through short-term practice under the same conditions.
The present study has contributed to the validation of the \ "e-IOA \ " in an English-speaking community setting in Ontario , Canada.
The present study has determined the distribution of T-cell phenotypes and their correlation to 2-year mortality in a cohort of Chinese male seniors.
The present study has explored licence restrictions as applied to Victorian older drivers over a ten-year period.
The present study highlights significant DNA damage in people exposed to FA.
The present study identified foods consumed at mealtimes and by race when combination codes were or were not utilized.
The present study included @number@ community-dwelling persons aged ≥65 years who were followed until @number@ for their vital status.
The present study included @number@ healthy men having different habitual patterns of daily locomotor activity.
The present study included @number@ subjects of European ancestry from @number@ studies.
The present study informs the development of future health promotion initiatives in this context.
The present study introduces four event detection algorithms for defining touch-down and foot-off during stair descent and stair ascent using segmental kinematics.
The present study investigated age-related structural brain changes in gray matter from young to early middle-age adulthood for males and females.
The present study investigated and characterized deletion mutants of this gene , @date@ in the nematodes.
The present study investigated different properties of autobiographical remembering as a function of discrete emotions and age.
The present study investigated evidence for race-related test bias in cognitive measures used in the baseline assessment of the ACTIVE clinical trial.
The present study investigated feedback as a strategy for facilitating prospective memory in the elderly.
The present study investigated how fast younger and older adults recovered from a distracted attentional state induced by rare , unpredictable sound events.
The present study investigated how the CNS resolves speed-accuracy trade-offs when forced to use PV to guide perturbation-evoked reach-to-grasp balance-recovery reactions.
The present study investigated melatonin secretion profiles and sleep patterns before and after cataract surgery.
The present study investigated object recognition impairment and the existence of category effects in patients with mild Alzheimer's disease.
The present study investigated one hypothesized explanation for these findings : Age-related differences in the tendency to make correspondent inferences.
The present study investigated the antiaging potential of HP biomass using the fruit fly Drosophila melanogaster as the animal model.
The present study investigated the association between genetic variation in folate metabolism and age-related cognitive decline in the ninth decade of life.
The present study investigated the association between postural tasks and center of pressure spatial patterns of three-dimensional statokinesigrams.
The present study investigated the associations between APOE genotypes and cognitive change over @number@ years in older community-dwelling individuals.
The present study investigated the degree to which an infants ' use of simultaneous gesture-speech combinations during controlled social interactions predicts later language development.
The present study investigated the effect of MMP-9 overexpression in macrophages on cardiac aging.
The present study investigated the effect of performing a cognitive task on normal walking speed in patients presenting to a memory clinic with cognitive complaints.
The present study investigated the effects of SIRT1 activation on prion protein-mediated neuronal cell death and examined its possible signals in intracellular apoptotic pathways.
The present study investigated the extent to which a particular type of fear extrapolates to other emotional responses to diverse threatening challenges.
The present study investigated the prevalence of dysphagia among patients with sarcopenia , and the association between the two conditions.
The present study investigated the relationship between cholesterol and NPS in AD.
The present study investigated the response of blood lipids to resistance exercise in old adults.
The present study investigated the role of working memory capacity ( WMC ) in the control of recollection in young and older adults.
The present study investigated whether baseline and longitudinal changes in speed and accuracy of IADL performance differed between persons with MCI and cognitively normal peers.
The present study investigated whether SMAP proteins interact genetically.
The present study investigated whether the analysis of saccadic eye movements could be used as a screening method for the assessment of driving ability.
The present study investigates age-and sex-related changes in a group of healthy middle-aged and older adults , participating in a three-wave study on cognitive aging.
The present study investigates the antitumor effect of Fomitopsis pinicola ( Sw.
The present study investigates the evolution of visual expertise for printed stimuli with aging.
The present study investigates the neurobiological mechanism underlying this hypothesis.
The present study investigates the relationship between DHEA serum levels and age and the risk of dementia in adults with DS.
The present study investigates whether age-related changes in metabolite concentrations occur in the healthy cervical spinal cord.
The present study investigates whether human skin fibroblasts suffer permanent damages due to a long-term exposure to GC excess.
The present study involved a large occupational cohort ( N = 887 , mean age = 44 , @percent@ male ) .
The present study is focused on the relationship between human age and protein oxidation in erythrocyte membranes in a healthy Indian population.
The present study is the first comprehensive examination of the long-term effects of ADF on general cardiovascular fitness in rats.
The present study is the first to demonstrate both age-deficits and age-equivalence in metacognitive prediction accuracy within a working memory paradigm.
The present study is the first to investigate this Nature Effect in older adults.
The present study is to verify the relationship between age and PPM implantation infection.
The present study offers an insight into the differences in hip loading profile in postmenopausal women during walking and running at different speeds.
The present study of @number@ community-dwelling non-demented individuals aged 70-90years aimed to examine age-related brain volumetric changes over two years.
The present study performed a comparison that can be useful in better addressing the skin improvement therapies for aging and in its prevention.
The present study proposed to assess the effects of physiological adult ageing on the proprioceptive control of movement and the related internal models.
The present study proposes to investigate age-related episodic memory impairment in encoding.
The present study provides evidence that brain ganglioside abnormality , in particular GM1 , may be involved.
The present study provides normative data of the mandible in an age- and sex-stratified manner , which can be helpful in clinical practice.
The present study provides opening angle and residual strain data throughout the course and around the circumference of the aorta harvested during autopsy.
The present study recruited @number@ healthy elderly men.
The present study reports a global and regional description of the annualized rate of grey matter loss and its evolution after the age of @number@
The present study reports descriptive normative measures for @number@ Italian verbal idiomatic expressions.
The present study reports the natural mycobiota occurring in dry-cured hams , and in particular on the incidence of mycotoxin-producing fungi.
The present study reports the preliminary short-term clinical outcomes of low-intensity pulsed ultrasound ( LIPUS ) for treatment for Achilles tendinopathy.
The present study reports therapeutic evidence for Kangen-karyu from pre-clinical animal experiments related to human diseases.
The present study revealed that AβpN3 was deposited in an age-dependent manner in canine brains.
The present study reveals a completely novel effect of acetazolamide , i.e. , interference with osteoinductive signaling and tissue calcification in kl / kl mice.
The present study seeks to validate the use of GVI in the older adult population.
The present study should analyze the effects of pre- and postmenopausal estrogen concentrations on chondrogenic cells.
The present study shows evidence for conscious motor intention in motor preparation prior to movement execution.
The present study shows no direct relationship between worsening health status and poor adherence.
The present study shows that , despite these changes , older adults can successfully compensate for degradations in speech perception.
The present study solves this contradiction.
The present study sought to address this gap by using a resource depletion paradigm.
The present study sought to determine changes in bacterial phagocytosis in aging alveolar Mϕ ( AMϕ ) and the underlying mechanisms.
The present study sought to determine the minimum number of trials that are required to obtain a reliable FRN component using a simple gambling paradigm.
The present study sought to provide such data for the Karolinska Sleepiness Scale.
The present study suggests a role for the ventral striatum in the development of clinical dementia.
The present study suggests that the metric assessment of the face may be used for age estimation on images.
The present study supports the hypothesis that greater arterial stiffness is a contributor to microvascular brain disease.
The present study supports the notion that systemic PES is not a life-threatening condition.
The present study tested specific biochemical and molecular effects of AGE in neuronal and AD rodent models.
The present study tested this prediction by examining age-related differences in behavioral and electrophysiological adaptations to prior conflict.
The present study therefore investigates functional deficiency in the inhibitory system as complementary to the identified alterations in the glutamate excitatory pathway in AD.
The present study used a novel interview method to examine the potential role played by mental representations of extended lifetime periods.
The present study used electrophysiological measures to study effects of age on auditory stream segregation in a multitalker scenario.
The present study uses an ecological momentary assessment design to examine how timing of daily stressors relates to age differences in negative emotional responses.
The present study utilized a novel method to quantify the gray-white matter boundary in eight ASD and eight typically developing control subjects.
The present study was a first look at the ontogenetic pattern of dream content across the lifespan for men.
The present study was aimed at determining IGFBP2 mRNA levels in adipose tissue in conditions of insulin resistance such as aging and obesity.
The present study was aimed at determining the frequency of genetic variations in MAPT in a south Indian FTD cohort.
The present study was aimed at identifying genetic modifiers modulating AAO in a large cohort of Italian FTD patients.
The present study was aimed to examine the effects of dietary cis- and trans-fatty acids on the model organism Caenorhabditis elegans.
The present study was an attempt to specifically address these issues.
The present study was carried out to investigate the in vitro free-radical quenching capacity of a known Ayurvedic poly-herbal formulation called Vayasthapana Rasayana.
The present study was designed to evaluate the apoptotic effect of SCRT against human non-small-cell lung cancer ( NSCLC ) A549 cells.
The present study was designed to evaluate the association between multimorbidity and subjective memory complaints.
The present study was designed to prospectively collect pharmacokinetic and safety data on age-adapted intrathecal liposomal cytarabine in children aged > 3 years.
The present study was intended to contribute to this literature.
The present study was undertaken to evaluate the impact of habitual physical activity and exercise types on physical performance across ages in community-living adults.
The present study was undertaken to investigate the mechanism responsible for the SBGE-induced apoptosis of MCF-7 human breast cancer cells.
The present survey found a close relationship among the HEV of Tibetan people and pigs.
The present systematic review revealed many ICT systems that could purportedly support the range of activities of daily living for patients with dementia.
The present theoretical framework of Alzheimer's disease proposes that pathophysiological changes occur 10-20 years before the diagnosis of dementia.
The present work acknowledged the novel PSEN1 pathogenic mutation M84V and might contribute to the ongoing debate about the involvement of cerebellum in AD.
The present work aims to suggest a pragmatic approach to achieve reasonable accuracy for performing patient dose surveys in countries with limited resources.
The present work concerns the cystatin C levels and degree of inflammation in longitudinal studies of individual subjects without inflammation , who undergo elective surgery.
The present work describes bibliographic analysis of ontogenetic changes in hormonal regulation of sleep and circadian biorhythms.
The present work examines how bilinguals perceive second language ( L2 ) accented speech and where accommodation to dialectal variation takes place.
The present work explores the application of information theoretical measures , such as entropy and normalized mutual information , for research of biomarkers of aging.
The present work provides evidence that within a group of persons with MS , there are gait differences that are influenced by falls history.
The preservation of muscle trophism may protect against various negative health outcomes.
The pressure decreased in @number@ instances ( @percent@ ) , most frequently with neck extension.
The presynaptic protein alpha-synuclein aggregates to form intraneuronal Lewy bodies in PD.
The pre-treatment of filter paper does not appear to be necessary.
The prevailing assumption is that HC / AG variability is small in young adults , and widens with advancing age and pathology.
The prevailing concept is that defects in memory T-cell populations result from inexorable end-stage differentiation as a result of repeated lifelong antigenic challenge.
The prevalence and domains of NMSs in untreated de novo PD remains unclear , especially comparing to normal aging.
The prevalence and factors of influence for MCI in older people living in publicly managed congregate housing are currently unknown.
The prevalence and incidence of symptomatic , radiographic and self-reported hip or knee OA were included.
The prevalence and incidence were estimated for each age and sex using Japanese volume of thyroidectomies and Japanese population data.
The prevalence and the magnitude of VMS may vary across populations.
The prevalence-based Sullivan method was used to disaggregate total life expectancy into expected life time without and with mobility limitations.
The prevalence currently is thought to be increasing because of more accurate diagnostic methods and aging of the population.
The prevalence data for atrial fibrillation ( AF ) are dated.
The prevalence decreased with education levels increasing ( χ ( @number@ ) = @number@ P < @number@ ) .
The prevalence estimates and the various patterns of BP reporting over time are presented as percentages.
The prevalence , incidence , clinical manifestations , and genetic components of PD are discussed in this review.
The prevalence increased for all the considered cancers except cervical cancer.
The prevalence increased with age increasing ( χ ( @number@ ) = @number@ P < @number@ ) .
The prevalence in the general population reported ranged from @percent@ to @percent@.
The prevalence in the Hui population was higher than other ethnic groups.
The prevalence in the northeastern states was relatively low.
The prevalence is estimated at ~10% of the French general practice patient population over @number@ years old.
The prevalence is expected to increase due to aging population.
The prevalence of abnormal was @percent@ , in which , the prevalence 1o sIAND was @percent@ and that of 2o sIAND was @percent@.
The prevalence of ACOS increases with aging , then it is relatively stable in elderly individuals ( > 65 years ) .
The prevalence of ACS was @percent@.
The prevalence of AD biomarkers was derived by adjusting for nonparticipation and standardizing to the Olmsted County , Minnesota , population.
The prevalence of AD increases with aging , and women have a higher predisposition to both AD and affective disorders than men.
The prevalence of AD is predicted to rise as life expectancy grows across populations.
The prevalence of adolescents who have both of PfS and social isolation and the risks for SI and SH among them are also unknown.
The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder ( PTSD ) .
The prevalence of allergic diseases in the elderly ranges from @number@ to @percent@ and appears to be rising.
The prevalence of A-LOC following syncope on tilting was @percent@ ( 44 / 159 ) .
The prevalence of Alzheimer's disease doubles after the age of @number@ years , every @number@ years.
The prevalence of anemia in a workforce averaging @number@ years old was @percent@.
The prevalence of annular fissure increased from @percent@ of those @number@ years of age to @percent@ of those @number@ years of age.
The prevalence of anxiety and somatization symptoms was higher than social dysfunction and depression symptoms.
The prevalence of anxiety syndrome was higher in the hearing-impaired group ( @percent@ vs. @percent@ , p = @number@ ) .
The prevalence of any cataracts was similar in north ( @percent@ ) and south India ( @percent@ ) .
The prevalence of aortic stenosis is increasing due to aging of the general population.
The prevalence of aortic stenosis is increasing with aging population.
The prevalence of aortic valve stenosis ( AS ) is increasing in the aging society.
The prevalence of arthritis in aging populations continues to rapidly grow.
The prevalence of assistance is higher and physical and cognitive capacity lower in each successive setting.
The prevalence of astigmatism was @time@ % ( @percent@ confidence interval : @number@ to @time@ ) and was not significantly related to age and gender.
The prevalence of atherosclerosis in four diverse ancient cultures is consistent with atherosclerosis being fundamental to aging.
The prevalence of atopy was @percent@ ( @percent@ in participants with rhinitis ) , and atopy did not show a significant association with rhinitis.
The prevalence of atrial fibrillation ( AF ) and the embolic risk increase with age.
The prevalence of atrial fibrillation ( AF ) is increasing in the United States as the population ages , but national surveillance is lacking.
The prevalence of balance disorders and associated symptoms and their impacts on self-reported functional limitations were determined.
The prevalence of bone disease is higher among HIV-infected subjects.
The prevalence of BTP was only shown to be lower in the oldest group ( O3 ) .
The prevalence of CAC ( CAC > 0 ) was @percent@ in men and @percent@ in women.
The prevalence of cardiovascular disease in the United States is extensive and growing rapidly.
The prevalence of cataract increases with the aging population.
The prevalence of ChD was @percent@ ( n = 557 ) .
The prevalence of childhood conduct disorder was significantly higher in the group with ICD.
The prevalence of chronic diseases and multimorbidity was calculated for the total population and subsequently by sex and age groups.
The prevalence of chronic organ damages increases as the age of patients followed in France.
The prevalence of chronic pain increases with age , exceeding @percent@ in individuals aged ≥65 years.
The prevalence of CI and BPH on autopsy is similar in Asian and Caucasian men despite very different diet and lifestyle.
The prevalence of cirrhosis increased from @percent@ in @number@ to @percent@ in @number@
The prevalence of CKD and of renal failure vary worldwide , yet parallel increases in leading risk factors explain only part of the differential prevalence.
The prevalence of CKD increases with old age.
The prevalence of clonal hematopoiesis increases with age , particularly after the fifth decade of life.
The prevalence of cobalamin deficiency increases with age ( ranges from @percent@ to @percent@ depending on the population studies and criteria for diagnosis ) .
The prevalence of cognitive impairment was @percent@.
The prevalence of cognitive impairment was @percent@.
The prevalence of co-morbidities was calculated , and the proportion of patients with each co-morbidity along with GOLD stages was analysed by chi-square for trend.
The prevalence of conditions associated with UC visits in men and women were identified.
The prevalence of confluent WMH was @percent@ , lacunes , @percent@ and microbleeds , @percent@.
The prevalence of constipation increases with age.
The prevalence of COPD increases with age.
The prevalence of COPD is two to three times higher in people over the age of @number@ years than in younger age groups.
The prevalence of coronary events was comparable in both groups.
The prevalence of correctable NVI increased with age from @number@ to 50-60 years and then decreased at all sites.
The prevalence of cortical , nuclear and posterior subcapsular cataract were assessed separately for the risk factors and its association with outdoor activity.
The prevalence of Cryptosporidium spp. was detected by microscopy and nested-PCR.
The prevalence of deleterious variants did not differ significantly between patients at primary diagnosis and relapse.
The prevalence of dementia among Hispanics is higher than that of non-Hispanic whites and they frequently present at a more advanced stage of illness.
The prevalence of dementia is predicted to rise worldwide partly due to an aging population.
The prevalence of dementia was @percent@ for participants aged @number@ years or older and @percent@ for those aged @number@ years or older.
The prevalence of dementia was significantly higher in rural areas than in urban ones ( @percent@ vs. @percent@ , P < @number@ ) .
The prevalence of dental caries and periodontal disease was high in the study population , and warrants intervention.
The prevalence of dental caries was @number@ % and increased with age.
The prevalence of depression ( CSDD score of 6 + ) was @percent@.
The prevalence of depression in this population was @percent@ ; @percent@ of the study sample was classified as \ " food insufficient \ " .
The prevalence of depression using three different cut-off points was calculated.
The prevalence of depressive symptoms , cognitive impairment , falls , and urinary incontinence were @percent@ , @percent@ , @percent@ and @percent@ , respectively.
The prevalence of depressive symptoms was assessed using the Geriatric Depression Scale.
The prevalence of diabetes and arthritis was higher in people with generalised obesity in both sexes.
The prevalence of diabetes and heart failure in AF subjects increased ( p < 0.001 ) .
The prevalence of disability and survival were compared using logistic and Cox models.
The prevalence of disability was @percent@.
The prevalence of disk degeneration in asymptomatic individuals increased from @percent@ of 20-year-old individuals to @percent@ of 80-year-old individuals.
The prevalence of DSD was @percent@ , and the prevalence of delirium and dementia alone were @percent@ and @percent@ , respectively.
The prevalence of DUA in different patient groups suggests that multiple aetiologies are involved in DUA pathogenesis.
The prevalence of each ATN group changed substantially with age , with progression towards more biomarker abnormalities among individuals who remained cognitively unimpaired.
The prevalence of elevated C-reactive protein was @number@ to @percent@ during the study.
The prevalence of erectile dysfunction is high in men of all ages and increases greatly in the elderly.
The prevalence of excessive daytime sleepiness was @percent@ overall and this was higher in males.
The prevalence of falls in older adults with MCI and AD is higher than in subjects cognitively healthy.
The prevalence of falls was about @percent@ among subjects and significantly increased with age ( p = @number@ ) .
The prevalence of fall was @percent@ ( @percent@ for men and @percent@ for women ) .
The prevalence of family dysfunction was @percent@ , including @percent@ severe and @percent@ moderate dysfunction.
The prevalence of fibrosis is rising worldwide , and to date no agents has shown clinical efficacy in the attenuating or reversing the process.
The prevalence of FI was @percent@ ( CI @percent@ , @number@.39-48.15 ) .
The prevalence of FI was @percent@ ( @percent@ female , @percent@ male ) .
The prevalence of frailty assessed using different models varied from @percent@ to @percent@.
The prevalence of frailty ranged from @percent@ to @percent@.
The prevalence of Frailty Syndrome ( FS ) is of potentially enormous significance , as it potentially affects 20-30% of adults older than @number@
The prevalence of frailty was @percent@ in this study , while pre-frailty was @percent@ and @percent@ of all participants were robust.
The prevalence of frailty was @percent@ using the modified frailty phenotype and @percent@ using the frailty index.
The prevalence of frailty was significantly higher among the HR NBL survivors @date@ ( @percent@ ) than among the controls ( @percent@ ) .
The prevalence of gastric mucosal changes also declined despite aging.
The prevalence of gastro-oesophageal reflux disease ( GORD ) has been increasing worldwide.
The prevalence of gingival bleeding , periodontal pockets and loss of attachment was @number@ @number@ and @percent@ , respectively.
The prevalence of gout and hyperuricemia were evaluated.
The prevalence of gout in the Han population was significantly lower than that in Hui population ( @percent@ vs. @percent@ ) .
The prevalence of hearing problems in the Western world has , due to aging of the population , doubled over the past @number@ years.
The prevalence of heart failure substantially increases with advancing age.
The prevalence of Helicobacter pylori infection was similar in both groups.
The prevalence of high BP was greater in men ( @percent@ ) than in women ( @percent@ ) .
The prevalence of high-risk status based on questionnaires for OSA was @percent@ ( @percent@ CI @percent@ , @percent@ ) .
The prevalence of hippocampal atrophy was compared between cases and control subjects by the use of the McNemar's test for correlated proportions.
The prevalence of histologically confirmed CIN or cancer was @percent@ in the HPV DNA screening arm vs @percent@ in the conventional screening arm.
The prevalence of HIV-associated neurocognitive disorder has not changed from the pre- to the potent antiretroviral therapy era , remaining at approximately @percent@.
The prevalence of HIV ( human immunodeficiency virus ) associated neurocognitive disorders ( HAND ) will undoubtedly increase with the improved longevity of HIV-infected persons.
The prevalence of HIV infection in this group was @percent@ , compared with @percent@ among those aged 15-49 years.
The prevalence of H. pylori was calculated for each quartile and for each birth cohort from @number@ to @number@
The prevalence of HTN is increasing in developing countries and is one of the leading causes of death in older individuals.
The prevalence of hypertension and diabetes increased with age , whereas the prevalence of obesity and high cholesterol decreased with age.
The prevalence of hypertension detected by OBPM dropped from @percent@ to @percent@.
The prevalence of hypertension increases with age making it a significant health concern for older persons.
The prevalence of hypertension increases with aging.
The prevalence of hypertension was significantly higher in passive smokers ( @percent@ ) than in non-passive smokers ( @percent@ ) .
The prevalence of hyperuricemia was @percent@.
The prevalence of Hypogonadism in diabetic and non-diabetic men was @percent@ and @percent@ , respectively.
The prevalence of hypovitaminosis D was @percent@ ( @percent@ insufficiency and @percent@ deficiency ) .
The prevalence of ICDs was investigated by using the modified version of the Minnesota Impulse Disorders Interview ( MIDI ) .
The prevalence of inadequate vitamin E levels is significantly higher among non-users of dietary supplements.
The prevalence of LAR in adult patients with a previous diagnosis of non-AR was assessed.
The prevalence of liver neoplasms was significantly higher in the CBA / W strain ( P < @number@ ) .
The prevalence of low , normal and high AAI was @percent@ , @percent@ and @percent@ , respectively.
The prevalence of low testosterone level is particularly high among patients with end-stage renal disease ( ESRD ) and has been associated with mortality.
The prevalence of low vitamin D status in the elderly population of subtropical area and the potential risk / protective factors have not been addressed.
The prevalence of L-PVSs was @percent@ ( median number of L-PVSs , @number@ range , 1-17 ) .
The prevalence of LT increased markedly with increasing BMI.
The prevalence of LVH was @percent@ in men and @percent@ in women.
The prevalence of LVOT origin I-VA increased with age compared to that for the RVOT.
The prevalence of macular cysts , LMHs , and ERMs was higher in eyes with a history of cataract surgery.
The prevalence of major depressive disorder was @percent@ to @percent@ , while that of clinically significant depressive symptom was between @percent@ and @percent@.
The prevalence of malnutrition among veterans was high compared to the community dwelling U.S. civilian elderly population.
The prevalence of malnutrition risk at the time of ICU admission of the patients aged ≥65 years old was @percent@.
The prevalence of malnutrition was significantly associated with the prevalence of physical frailty ( P < @number@ ) .
The prevalence of MCI increased with age and was higher in men.
The prevalence of mental health disorders among the elderly is often unrecognized.
The prevalence of MetS is @number@ % ( @number@ % CI @number@.1-42.9 % ) .
The prevalence of minor ECG abnormalities was similar among survivors and controls ( @percent@ vs @percent@ , P = @number@ ) .
The prevalence of minor polypharmacy and major polypharmacy was @percent@ and @percent@ respectively.
The prevalence of moderate stenosis ( 50-70% ) increases from @percent@ for those < 70 years to @percent@ in those ≥70 years.
The prevalence of moderate to severe levels of SDB reached @percent@ in all subjects.
The prevalence of Modic changes and IVD pathology were greater in L4 / 5 and L5 / S1 , compared with the upper lumbar spine.
The prevalence of MS increased among the groups with higher levels of hs-CRP.
The prevalence of multimorbidity patients with DI ranged from @number@ to @percent@ and the number of DIs per @number@ patients was from @number@ to @number@
The prevalence of NAFLD also increases with age.
The prevalence of neurological disease , such as dementia , stroke , and peripheral neuropathy , is large and growing consequent to the aging population.
The prevalence of neurological disorders and signs was assessed by physical examination and medical interview.
The prevalence of non-dipping BP was @percent@.
The prevalence of OAB was closely associated with aging ( P < @number@ ) and the degree of LUTS ( P < @number@ ) .
The prevalence of obesity increased with age , notably when defined by WC.
The prevalence of OH is higher in older people because of comorbidities , polypharmacy , and physiological changes that occur with aging.
The prevalence of OSAS increases with aging , occurring in up to @percent@ of older adults and up to @percent@ in patients with Alzheimer's disease.
The prevalence of osteoarthritis increased with aging both in men and women.
The prevalence of osteoporosis increases with advancing age.
The prevalence of overall cognitive disorder was @time@ % ( 95%CI : @number@.22%- @time@ % ) .
The prevalence of over-weight ranged from @percent@ to @percent@ in both surveys.
The prevalence of patients on RRT varies from @number@ pmp. in Paraguay and @number@ pmp in Chile.
The prevalence of PD increases with age.
The prevalence of physical inactivity worldwide is @percent@ , however there is insufficient data from prevalence and trends of physical inactivity in Mexican population.
The prevalence of PIMs was @percent@ and @percent@ at baseline and @number@ months later , respectively.
The prevalence of pinguecula and pterygium and their relationship with lifestyle factors and ocular and systemic diseases was investigated.
The prevalence of polypharmacy among the participants was @percent@ , with @percent@ of those participants using five or more medications.
The prevalence of polypharmacy substantially increased with age and with a higher number of chronic conditions.
The prevalence of polypharmacy was measured together with subject characteristics found to be predictive of polypharmacy exposure.
The prevalence of positive ADAM and low serum BT is increasing with age.
The prevalence of prescription medication use among the ambulatory adult population increases with advancing age.
The prevalence of protrusion was @percent@ and previous open bite @percent@.
The prevalence of psychotropic drugs usage is growing in the general population.
The prevalence of pterygium was @percent@ ( @percent@ CI : @number@.3-7.9 ) .
The prevalence of reduced cortical thickness was @percent@ ( @number@.4%-31.5% ) : women , @percent@ ; men , @percent@.
The prevalence of reports ranged from @number@ to @number@ % for victims older than @number@ years.
The prevalence of rhinitis was @percent@ and did not decrease until @number@ years of age.
The prevalence of SADW in the study population was @percent@ and sub-SADW @percent@.
The prevalence of SAH , dyslipidemia and diabetes mellitus did not influence the results.
The prevalence of sarcopenia was inversely correlated with body mass index.
The prevalence of sarcopenia was @percent@ after one year.
The prevalence of sarcopenia were calculated using different diagnostic criteria.
The prevalence of sarcopenic obesity was lower by using RASM than SMI ( @percent@ vs @percent@ , P < @number@ ) .
The prevalence of S. aureus and MRSA carriage among the elderly was @number@ % and @number@ % , respectively.
The prevalence of self-medication varied between @number@ and @percent@ , and the majority of studies reported values between @number@ and @percent@.
The prevalence of self-reported constipation increased from @percent@ in 1992-1993 to @percent@ in 2003-2004.
The prevalence of self-reported hypertension ( @percent@ ) and diabetes mellitus ( @percent@ ) are high.
The prevalence of severe WMH ( Fazekas score = @number@ ) was significantly higher in patients with delirium.
The prevalence of SIS among autistic individuals was @percent@ and that of PP was @percent@ ( @percent@ in controls ) .
The prevalence of SIS increased with intelligence and age.
The prevalence of SMC depends on age , education , sex , mood and cognitive performance.
The prevalence of subsequent neoplasms after CRT exposure was @number@ % ( @number@ of @number@ ) .
The prevalence of supraventricular arrhythmias among AMA-M2-positive patients was higher than that among AMA-M2-negative patients ( @percent@ vs. @percent@ , p = 0.008 ) .
The prevalence of suspicion for mental disorders was higher in urban ( @time@ % ) than rural areas ( @percent@ ) .
The prevalence of target-organ damage and raised BP increases with aging.
The prevalence of the 65-74 years group was as high as @percent@.
The prevalence of the metabolic syndrome ( Adult Treatment Panel III definition ) remained stable across the age groups.
The prevalence of these crystals dramatically increases with age , and crystals are typically found in osteoarthritic cartilage and synovial fluid.
The prevalence of these deposits was associated with the duration of disease rather than with aging.
The prevalence of this symptom is without doubt underestimated , although its presence often underlines thymic suffering that is more striking.
The prevalence of TIAs was @number@.15 / 1 , 000.
The prevalence of TMD was @percent@ among non-institutionalized elderly individuals and of @percent@ among institutionalized individuals.
The prevalence of tobacco use was @percent@.
The prevalence of type @number@ diabetes mellitus ( T2DM ) is increasing in the elderly.
The prevalence of unoperated cataract increased with age and was higher in women than men ( odds ratio [ OR ] , @number@ ) .
The prevalence of urinary incontinence ( UI ) increases with age and can negatively affect quality of life.
The prevalence of valvular heart disease ( VHD ) in the United States was estimated to be approximately @percent@ in the 1990s.
The prevalence of VC among KT and CKD patients were @percent@ and @percent@ , respectively , ( P = @number@ ) .
The prevalence of VCI is high in ischemic stroke patients , and there are different impact factors at different stages.
The prevalence of vitamin D insufficiency ( 25OHD level of 20-29 ng / mL ) among the elderly in Dakahlia was @number@ %.
The prevalence of vitamin D , insufficiency in the general German population is high.
The prevalence OH in frail participants was @percent@ , compared to @percent@ in robust.
The prevalence , predictors and outcomes of malnutrition on admission to hospital are not clear for this population.
The prevalence rate increased with age ( X2 = @time@ , P < @number@ ) .
The prevalence rate of advanced schistosomiasis was @number@.46 / 10 , 000.
The prevalence rate of cognitive frailty was @percent@.
The prevalence rate of undiagnosed HT was @percent@.
The prevalence rates became relatively low among those over the @number@ years old than expected.
The prevalence rates of Alzheimer's disease and vascular dementia were @percent@ ( @percent@ CI @number@.0-4.3% ) and @percent@ ( @percent@ CI @number@.5-1.1% ) .
The prevalence rates of cortical , nuclear and posterior subcapsular cataract per person were @percent@ , @percent@ and @percent@ , respectively.
The prevalence rates of frequent snoring , breathing pauses , and EDS were @percent@ , @percent@ , and @percent@ , respectively.
The prevalence rates of ICDs seem to decrease with aging.
The prevalences of BMLs and large BMLs in the tibiofemoral compartments were @percent@ and @percent@ , respectively.
The prevalences of multimorbidity and polypharmacy in people over @number@ with intellectual disabilities are comparable to those of the Dutch nursing home population.
The prevalences were only modestly lower in men without prevalent chronic diseases.
The prevalence was also higher in subjects who never married and in subjects with an APOE epsilon3epsilon4 or epsilon4epsilon4 genotype.
The prevalence was higher among females and persons born in the Isle of Man at both time points.
The prevalence was measured as the percentage of patients with at least @number@ PIM during 1-year period.
The prevalence was @percent@ , and most pronounced among the oldest women ( @percent@ ) .
The prevalence was twice the incidence for lung cancer in both sexes.
The prevalent population was estimated based on those who were still alive in @number@
The prevention and adequate management of T2DM are , to a great extent , contingent on access to healthy food environments.
The prevention and adequate treatment of LLD may help to reduce premature disability and death among elders with depressive symptoms.
The prevention and control of prostate cancer should be strengthened.
The prevention of infectious diseases affecting the elderly can be successful only through a holistic approach.
The previous and current trends in facial crease classification are also discussed.
The previous chapter focused on the conceptualization and operationalization of the deficit accumulation and phenotypic approaches to the description of frailty.
The previous guideline recommended against the inclusion of lumbar fusion in the absence of spinal instability or a likelihood of iatrogenic instability.
The previously measured ( @number@ ) H NMR spectra were re-analyzed using LCModel with the Asc spectrum included in the basis set.
The previous study generated a preliminary pharmacophore for the quercetin binding site on SIRT6 , containing @number@ hydrogen bond donors and one hydrogen bond acceptor.
The primary aim is to evaluate different laboratory parameters at age-related reference intervals.
The primary aim of this study is to examine the potential influences of birth cohort and gender on LTSS planning.
The primary aim of this study was to critically discuss available evidence regarding the potential mechanisms relating shorter telomeres to periodontitis.
The primary aim of this study was to delineate the functional networks that subserve the recognition of emotional expressions as a function of eye gaze.
The primary aim of this study was to describe the outcome following open , ankle fragility fracture.
The primary aim of this study was to find the prevalence of malnutrition among Veterans enrolled in HBPC programs.
The primary aim of this study was to investigate the role of sensory nerves in this age-related change.
The primary aim of this study was to investigate whether renal tissue alterations associated with vesicoureteral reflux ( VUR ) can be displayed by DWI.
The primary analysis examined the association between age at surgical menopause and decline in a global cognition score.
The primary analysis focused on determining if the eGFR-mortality relation differed by the extent to which the eGFR was consistent with normal aging.
The primary analysis is a non-inferiority analysis with a non-inferiority upper limit for the HR for the primary outcome of @number@
The primary behavioral defect was that flies expressing either hTDP-43 G294A or M337V showed a faster decline with age in negative geotaxis.
The primary chronic symptom in patients with HFpEF , even when well compensated , is severe exercise intolerance.
The primary composite endpoint was cardiovascular death , non-fatal myocardial infarction , and non-fatal stroke , which occurred in @number@ patients during follow-up.
The primary concern of staff from the residents ' former group homes was social isolation.
The primary CVD outcome was a composite of myocardial infarction , stroke and cardiovascular death.
The primary data from 28-day survivors and nonsurvivors were compared.
The primary dichotomized outcome was favorable neurological outcome ( cerebral performance category , 1-2 ) , evaluated by logistic regressions.
The primary effectiveness end point was noninferiority of VYC-15L versus NASHA by mean change in LFS score from baseline to Month @number@
The primary effect measure was the difference in means of the final measurements between the intervention and control groups.
The primary efficacy end point was mean change in Wrinkle Assessment Scale ( WAS ) scores at @number@ months.
The primary efficacy endpoint was satisfactory relief of abdominal pain / discomfort for at least half of the weeks of the treatment period.
The primary efficacy endpoint was the improvement rate at maximum frown at week @number@ by the investigators ' live assessment.
The primary efficacy outcome was the change in chest CT-measured RV / LV diameter ratio at @number@ hours after procedure initiation.
The primary efficacy variable was the change from baseline in mean 24-hour ambulatory SBP after @number@ weeks.
The primary endpoint ( cognition ) has previously been reported.
The primary endpoint is patient-reported functional status as measured by the Stroke Impact Scale @number@
The primary endpoint of the study is the change in hippocampal volume over time in patients with and without POCD.
The primary endpoint of the trial is the change in short physical performance battery score and percentage of patients maintaining or improving their physical performance.
The primary endpoints were early and midterm rates of survival and limb salvage.
The primary endpoints were outcomes and predictors of in-hospital mortality.
The primary endpoints were time until medically fit for discharge and length of hospital stay.
The primary endpoint was 12-month all-cause mortality.
The primary endpoint was a composite based on the incidence of hospital mortality and / or the incidence of at least one organ failure.
The primary end point was all-cause mortality , and hazard ratios were estimated using a Cox proportional hazard model.
The primary endpoint was a repeat visit to the hospital for another traumatic condition after discharge , and the secondary endpoint was death.
The primary endpoint was clinical response to meropenem therapy.
The primary endpoint was health-related quality of life assessed by questionnaires.
The primary end point was hospital admission during the follow-up period.
The primary endpoint was incidence of any treatment-emergent serious adverse events measured at @number@ month postinfusion.
The primary endpoint was incidence of treatment-emergent serious adverse events ( TE-SAEs ) at 1-month postinfusion.
The primary endpoint was in-hospital mortality and the secondary endpoint was failure of discharge to home.
The primary endpoint was investigator-assessed change in NLF severity over @number@ months using the validated photonumeric NLF Severity Scale.
The primary end point was investigator-assessed progression-free survival.
The primary endpoint was mortality at one-year follow-up.
The primary end point was recurrent infection ( new episode after initial clinical cure ) within @number@ weeks after infusion in the modified intention-to-treat population.
The primary end point was the accuracy to diagnose a cardiac syncope.
The primary endpoint was the development of proven or probable IFD.
The primary endpoint was the improvement of depressive symptoms as evaluated by Geriatric Depression Scale ( GDS ) .
The primary end point was the time to illness alleviation.
The primary end point was total procedural duration.
The primary endpoint will be assessment of valsartan efficacy to prevent left ventricle remodeling during @number@ month follow-up.
The primary endpoint will be the change in maximum exercise capacity ( peak V'O2 ) .
The primary exposure was time to / from the FMP.
The primary facilitator was a desire to offer programs that were of interest and beneficial to seniors.
The primary feature of AD is progressive cognitive decline , and severe AD is characterized by reduced communication skills and mobility.
The primary features of FXTAS are late-onset intention tremor and gait ataxia.
The primary function of crystallins is to maintain the clarity of the lens through ordered interactions as well as through the chaperone-like function of α-crystallin.
The primary goal is the new development of CKD.
The primary goal is to update the different trends in over-nutrition by gender and location among elderly Chinese.
The primary goal of this review is to determine if there are body composition methods that can accurately track body composition from infancy into adulthood.
The primary goal of this study was to obtain N-glycan profiles of human placental membrane proteins using a reliable , simple and high-throughput method.
The primary independent variable was elder abuse reported to a social services agency.
The primary indications of the procedure were upper lid dermatochalasis with lateral hooding.
The primary limitation is the potential bias attributable to nonresponders.
The primary method used was cross tabulation.
The primary microstructural unit of cortical bone , the secondary osteon or Haversian system , is widely assumed to have a cylindrical shape.
The primary objective is to review the literature on non-pharmacological management for FTD and to propose directions for future research , with reference to findings.
The primary objective of our study was to examine the hospital-level variation in rates of new institutionalizations among Medicare beneficiaries.
The primary objective of surgery is to reconstitute the spinal canal.
The primary objective of this paper was to assess the safety of cultured ASCs.
The primary objective of this study was to evaluate the effect of various urologic procedures in prostatic area on serum free and total PSA levels.
The primary objective of this study was to provide supplementary normative data on aging and cognition from an ongoing community-based study.
The primary objective was between-group comparison of duration of maintaining the HbA1c goal in older patients ( ≥65 years of age ) .
The primary objective was to compare weight change and the remission rate of co-morbidities in the @number@ groups after @number@ months of follow-up.
The primary objective was to examine what predicts the speed of processing training gains observed in the previous study.
The primary outcome event was any stroke or death.
The primary outcome is a comparison of the change in fatigue from baseline to @number@ months between Intervention and Control arms.
The primary outcome is a composite memory score from the Rey Auditory Verbal Learning Test.
The primary outcome is a composite of 1-year all-cause mortality and hospital readmission for any cause.
The primary outcome is blood pressure ( BP ) control ( systolic BP < 130 mmHg ) at @number@ year.
The primary outcome is conversion to a clinical diagnosis of dementia.
The primary outcome is physical activity as assessed by the Community Healthy Activities Model Program for Seniors ( CHAMPS ) Questionnaire at @number@ months.
The primary outcome is quality of care for older residents using a composite measure of quality indicators from the interRAI LTCF assessment system.
The primary outcome is repeat ED use within @number@ days ; secondary outcomes are patient satisfaction with care and total costs.
The primary outcome is the change in Revised Fibromyalgia Impact Questionnaire total score from baseline to @number@ weeks.
The primary outcome is the decline in visual acuity at CNV diagnosis from baseline.
The primary outcome measure is health-related quality of life according to the 15D instrument.
The primary outcome measurement was the Berg Balance Scale ( BBS ) .
The primary outcome measures included Modified Barthel Index score , Mini-Mental Status Examination score , and the institutionalization rate.
The primary outcome measures were changes in fasting plasma glucose , serum insulin and HOMA-IR , an index of insulin resistance.
The primary outcome measures were hemorrhage and vascular obstruction.
The primary outcome measures were Modified Barthel Index ( MBI ) and Mini-Mental Status Examination ( MMSE ) scores.
The primary outcome measures will be muscle mass , size and strength and cognitive function.
The primary outcome measure was decline in gait speed of @number@ m / s or more in the following year of statin use.
The primary outcome measure was falls ; the secondary outcome measures included gait , balance function and reaction time.
The primary outcome measure was postoperative length of stay ( PLOS ) .
The primary outcome measure was the comparison of CVFD detection rates.
The primary outcome measure was the number of DRPs leading to a recommendation for drug change.
The primary outcome measure was the Stroop Test , a cognitive test of selective attention and conflict resolution.
The primary outcome measure was the time to adjudicated all-cause dementia and Alzheimer dementia ( AD ) .
The primary outcome measure was the Work Ability Index ( WAI ) , and the level of physical activity was measured using a single-item question.
The primary outcome measure was useful field of view test ( UFOV ) performance , and secondary outcomes included cognitive self-perceptions and depressive symptoms.
The primary outcome of interest was change in Alzheimer's Disease Assessment Scale cognitive subscale ( ADAS-cog ) scores over @number@ months.
The primary outcome of interest was evaluation of cognitive changes in older people after anticholinergic discontinuation , measured using cognitive assessment scales.
The primary outcome results were reported in @number@ clinical trials with explicit and relevant data on older people.
The primary outcomes are traditional smoking cessation rates and number of smoked cigarettes.
The primary outcomes evaluated were level of independence in mobility at discharge and @number@ months after surgery.
The primary outcomes were measures of functional outcomes ; secondary outcomes were balance , gait , strength , power , muscle volume and adverse effects.
The primary outcomes were prostate volume measured by magnetic resonance imaging , serum prostate specific antigen and androgen levels.
The primary outcomes were volumetric BMD of the hip and spine measured by quantitative computed tomography ( QCT ) and biochemical markers of bone turnover.
The primary outcomes were work ability , vitality and productivity.
The primary outcomes will be cancer incidence and cancer mortality in association with a central nervous system disorder.
The primary outcomes will be collected to determine downstream resource utilization.
The primary outcome was 30-day mortality , and secondary outcomes included 30-day morbidity and FTR.
The primary outcome was a combined outcome of CABG and PCI in @number@ years.
The primary outcome was a composite of nonfatal acute myocardial infarction , nonfatal stroke , or cardiovascular death.
The primary outcome was a composite of recurrent venous thromboembolism or major bleeding during the @number@ months after randomization , regardless of treatment duration.
The primary outcome was admission avoidance from the ED , with readmissions , length of stay and bed-day use as secondary outcomes.
The primary outcome was a sum score indicating how many ADLs ( out of @number@ ) the patient was able to perform without difficulty.
The primary outcome was cardiovascular events after @number@ years of follow-up , with data obtained from national registries.
The primary outcome was change in cognition as measured through comprehensive neuropsychological test battery ( NTB ) Z score.
The primary outcome was change in HbA1c-concentration after @number@ and @number@ months.
The primary outcome was change in Short Physical Performance Battery total scores.
The primary outcome was CONSORT @number@ reporting quality.
The primary outcome was CVD ( acute myocardial infarction [ AMI ] , unstable angina , ischemic stroke , and heart failure ) .
The primary outcome was CVM.
The primary outcome was frailty , determined using the 36-item Carolina Frailty Index ( CFI ) .
The primary outcome was incidental VTE.
The primary outcome was major CHD ( myocardial infarction or CHD death ) .
The primary outcome was muscle strength , as assessed by one-repetition maximum ( 1-RM ) tests.
The primary outcome was neurocognitive functioning and secondary outcomes were physical functioning and plasma levels of BDNF.
The primary outcome was postoperative delirium as measured by the Confusion Assessment Method.
The primary outcome was postoperative delirium , assessed using the Confusion Assessment Method ( CAM ) .
The primary outcome was relative increase in physical activity measured objectively using ankle- and wrist-worn accelerometers.
The primary outcome was survival.
The primary outcome was survival from randomization to month @number@
The primary outcome was the absence of any DSM-IV depressive disorder at six-month follow-up.
The primary outcome was the cessation rate at the longest follow-up period.
The primary outcome was the composite endpoint of drug discontinuation and dose reduction of drugs taken on admission.
The primary outcome was the duration of moderate-to-severe hot flushes estimated by survival analysis ( n = 259 ) .
The primary outcome was the incidence of delirium.
The primary outcome was the incidence of phlebitis associated with anatomical site of peripheral catheterization.
The primary outcome was the number of hospitalizations / person-day alive among long-stay patients with advanced dementia or cardiopulmonary disease.
The primary outcome was the number of prescription drugs to which individuals were exposed during the last @number@ months before death.
The primary outcome was the proportion of participants in each preclinical AD stage.
The primary outcome was the proportion of patients with a diagnosis of osteoporosis and without contraindications to anti-osteoporosis medicines who were prescribed an anti-osteoporosis medicine.
The primary outcome was the rate of ED use.
The primary outcome was the risk of disease recurrence.
The primary outcome was time to complete a 400-m walk in seconds ( 400MWT ) .
The primary outcome was total score of the Pittsburgh Sleep Quality of Index ( PSQI ) .
The primary outcome , which is a person reported outcome , is the SF-36 Mental Health dimension at six months post randomisation.
The primary outcome will be self-perceived performance , and satisfaction with performance of daily activities , assessed with the Canadian Occupational Performance Measure.
The primary outcome will be weight loss.
The primary predictor at baseline was PIM use based on @number@ Beers Criteria.
The primary predictor variable was the score on the ERA Index , an instrument that predicts emergency room visits and hospitalization.
The primary predictor was elder self-neglect reported to social services agency.
The primary predictor was estimated GFR ( eGFR ) calculated using serum cystatin C ( eGFR ( cys ) ) .
The primary purpose of telomeres is to protect chromosome ends from erosion during cell division cycles.
The primary purpose of the present study was to examine the roles of self-focused attention and depressive symptomatology in subjective memory complaints.
The primary purpose of this study was to examine age differences in processing strategies of emotionally difficult trade-off decisions.
The primary purpose of this study was to test whether there is regional cerebral age-related hypometabolism specifically in later stages of life.
The primary purpose of this trial was to assess the effectiveness of ketamine for prevention of postoperative delirium in older adults.
The primary purposes of this study were to determine whether GT placement in patients with A-T would be tolerated and associated with caregiver satisfaction.
The primary reactive insults associated with the aging process are a result of oxidative stress ( OS ) and nitrosative stress ( NS ) .
The primary role of mitochondria was long considered to be production of cellular energy.
The primary safety end point was rate of serious adverse events ( AEs ) through @number@ months after treatment.
The primary safety outcome was device-related serious adverse events.
The primary safety outcome was major bleeding within @number@ hours.
The primary search terms were ' constipation ' and ' probiotics'.
The primary study outcomes were change in IPSS , BP , and heart rate from baseline.
The primary study outcomes were gross infarcts , neuritic plaques , and neurofibrillary tangles , ascertained using consensus guidelines.
The primary study point was oral intake discontinuation after the initiation of oral intake during hospitalization in cases of recurrent aspiration.
The primary task involved a closed-set sentence-recognition test , and the secondary task involved a vibrotactile pattern recognition test.
The primary themes that emerged in the literature are ageism and stigma , gender , mental health , and social supports.
The primary treatment method for chronic heart failure is pharmacotherapy , but it has limitations.
The primigravid pregnant , cesarean section and vaginal delivery groups had higher electromyographic activity than the postmenopausal group.
The principal component analysis ( PCA ) is applied as one of the common and frequently used methods in the construction of the BA formula.
The principal components analysis revealed @number@ factors interpreted as reflecting verbal memory and executive functioning.
The principal component scores ( PC scores ) generated from the model were analyzed for group differences using independent samples t-tests.
The principal direction of loading at @percent@ humerus length was towards mediolateral plane , likely due to fixing the humerus close to the torso.
The principal factors associated with BRD were widowhood and lower level of education.
The principal marker of arterial aging is an increase in arterial stiffness and pulse pressure.
The principal outcomes and related survival rates for this population were compared.
The principal plantar flexors , consisting of the bi-articular gastrocnemeii and the mono-articular soleus , appear to be affected differently by the aging process.
The principal risk factors are immunosenescence and immunosuppression.
The principle cause of heart failure is the loss of self-renewal ability of cardiomyocytes in various injuries such as myocardial infarction.
The principle of a type Ellman monopolar radiofrequency at a rate of @number@ MHz Pellevé , Surgitron Dual RF S @number@ is described.
The principle of respirometric OXPHOS assessment is centered around measuring oxygen concentration utilizing a Clark electrode.
The principles highlight the critical nature of cumulative exposure memories in defining changes in resilience progressively during life.
The principles of managements were adequate drainage , infection control during acute period and radical surgery during quiescent period.
The principles of the technique put forth apply equally to volumetric enhancements obtained through successful fat grafting and to the promise of ADSCs.
The principles of treating rheumatoid arthritis ( RA ) have changed considerably in recent years.
The PR interval and QRS duration in their previous ECGs were analyzed retrospectively.
The PR interval gradually increased with age , but no ECGs showed an abnormally prolonged PR interval.
The pro-allele of a TP53 polymorphism in codon @number@ ( rs1042522 ) has been associated with longevity.
The probability of a recipient pregnancy increased by almost @number@
The probability of becoming a centenarian varies significantly among the Japanese prefectures.
The probability of death was calculated for each patient based on these scores.
The probability of developing a cataract rises with age because of biochemical aging processes.
The probability of experiencing a TEAE was significantly influenced by use of multiple concomitant medications.
The probability of exposure to Ae. aegypti bites was highest in urban areas , outdoors and in the afternoon hours.
The probability of finding disease modifiers is enhanced in individuals with extreme HD phenotypes.
The probability of forming proper telomere structures depends on the length of the telomeric DNA tract.
The probability of fractures of the cortical shell of vertebral bodies increases as ageing progresses.
The probability of having HTN was significantly higher with increasing age with @number@ ( @percent@ ) of the participants > 50 years of age.
The probability of longevity may be a useful concept when informing the general public about the benefits of a healthy lifestyle.
The probability of obtaining a specific diagnosis of AAP increases with aging.
The probability of older patients actually receiving a deceased donor kidney transplant is unclear , preventing informed choice about pursuing the option of transplantation.
The probability of staying at the same status was higher at the two intervals across @number@ years.
The probability that dabigatran is cost-effective at a conservative willingness-to pay threshold of €20 , 000 per QALY was @percent@.
The probable role of neuronal plasticity and molecular mechanisms in training effects also are discussed.
The proband and each of his parents were heterozygous for a mutation in WRN , which could not explain his symptoms.
The proband and ten family members of Iranian ancestry participated in this study.
The proband had a homozygous mutation at c.293-13C in the second intron of CYP21 gene , while the parents had heterozygous mutations.
The proband manifested slow and progressive parkinsonism at @number@ years.
The proband possessed an intermediate phenotype.
The proband presented with memory and other cognitive symptoms at age @number@
The probe also ensures that both measurements are performed under equal conditions and at the same skin location.
The probe response completely recovered at the MPI of @number@ sec in NH listeners and at the MPI of @number@ sec in CI users.
The probe was guided at a deliberate pace , treating a surface area of @number@ cm2 every two minutes.
The probing of contextual information came as a surprise for all participants.
The probiotic group also showed decreased concentrations of the pro-inflammatory cytokine IL-8 but increased antimicrobial peptide hBD-2.
The problem cannot be addressed solely on an individual patient , individual clinician basis.
The problem is often multifactorial , necessitating a multidisciplinary evaluation and treatment approach that addresses biological , psychological , sociocultural , and relational factors.
The problem of comorbidity and multimorbidity in geriatrics is the most actual and required today.
The problem of mild dehydration is also likely common in animal field studies , which may also benefit from these collection and assay protocols.
The problem requires further study.
The problems surrounding pharmaceuticals are related to centralized , strict drug pricing control under the universal health coverage.
The problem was of sufficient magnitude to result in a high percentage of patients proceeding with treatment.
The procalcitonin time course was analyzed according to the therapeutic efficacy.
The procedural complete-success rate was @percent@.
The procedure gives more weight to recent outcomes and down-weights the influence of outcomes further in the past.
The procedure involves injection of bone cement into a fractured vertebra.
The procedure is extremely well tolerated , requiring only topical and ice anaesthesia.
The procedure is simple , and the anatomic causes for deepening of the nasolabial folds can be corrected.
The procedure proved to be a reliable and consistent technique that provided satisfactory results in carefully selected patients.
The procedure results in a relatively low number of these cells , which can decrease with donor's age.
The procedure results in significant central face skin tightening and wrinkle reduction.
The procedures of both memory tasks included encoding and memory test phases separated by a short delay.
The procedure starts in the case of moderate behavioral problems.
The procedures were well tolerated , and subject and investigator satisfaction with treatment results was very high.
The procedure was performed in less than @number@ minutes and was well tolerated.
The process compelled participants to think critically , collaboratively and in nontraditional ways.
The processes causing this phenomenon are incompletely understood.
The processes driving these increases in mortality and morbidity are often conceptualised as highly complex and multi-causal.
The processes of myogenesis and osteogenesis involve common mechanisms with skeletal muscle cells and osteoblasts sharing the same precursor.
The processing of all face aspects activated the core face-network across the age range , as well as additional and partially separable regions.
The process is a consequence of accelerated oocyte atresia , diminished number of germinated cells , and central nervous system aging.
The process is homogeneous and the affected lens fibres retain their gross morphology.
The process is sensitive to oxidative stress and ER stress.
The process of ageing has an impact on the entire human body including the organ systems.
The process of aging impacts many of the world's top health concerns.
The process of aging involves the accumulating changes in the microenvironment that lead to cell senescence or apoptosis , and subsequent tissue or organ dysfunction.
The process of aging is the result of subcutaneous loss of volume , in addition to vertical tissue descent.
The process of analysis of the studies involved reading titles , abstracts and full texts.
The process of cancer development consists of three sequential stages termed initiation , promotion , and progression.
The process of human aging is complex and individualized , occurs in the biological , psychological and social sphere.
The process of immunosenescence is accelerated in rheumatoid arthritis ( RA ) .
The process of inflammation consists of two stages.
The process of leg lateralization is finishing about 6th year of life.
The process of macroautophagy is compromised in diseases , such as cancer , neurodegenerative disorders , and diabetes.
The prodromal stage of AD is characterized by mild cognitive impairment ( MCI ) , representing a transitional state between normal aging and AD.
The production and clearance of Aβ in the brain are regulated by a large group of genes.
The production and expression of IL-1β , TNF-α , IL-18 and IL-18BP were measured by enzyme-linked immunosorbent assay and quantitative real-time PCR.
The production of reactive oxygen species and oxidative damage are high in the brains of aged SAMP10.
The production of reactive persulfide and polysulfide species in the lungs of patients with COPD remain unknown.
The production of ROS and the aberrant morphology of nuclei were detected by cell staining with the fluorescent dies Dihydrorhodamine @number@ and DAPI , respectively.
The production of type I IFN was significantly lower in DCs from older donors , compared with younger donors.
The products differ by their cross-linking process.
The products were separated on an @percent@ polyacrylamide gel and confirmed using Sanger sequencing.
The profile of auditory processing deficits among older adults with cognitive impairment may include multiple domains.
The profile of effects by GH therapy may be somewhat different than that of IGF-1.
The profile of metabolites provides better prognostic value versus conventional biomarkers.
The profile of mis-attachments exhibited is consistent with the types of chromosome segregation error observed in aged oocytes.
The profile of responses on four additional subquestions on RBD and one on obstructive sleep apnea improved specificity.
The profiles of mesenteric and pancreatic lymph nodes differ and often change reciprocally due to directed migration of T cells towards the site of inflammation.
The profiles of sIBM patients are similar to those in Western countries.
The profiles populated by these subjects as defined by HI did not vary with age or gender.
The progeria syndromes appear to cause rapid aging through disruption of normal nuclear structure.
The prognosis and clinicopathologic features of CRC in the young , compared with those in older patients , continue to be debated.
The prognosis for men after a hip fracture is very grim.
The prognosis of chronic lymphocytic leukemia ( CLL ) is very heterogeneous.
The prognosis of HF patients is still poor despite recent advances in HF treatment.
The prognosis of non-melanoma skin cancer improves significantly with early diagnosis , as well as with guideline-compatible treatment and follow-up.
The prognostic evaluation of elderly patients with chronic kidney disease ( CKD ) plays a key role in the decision analyses of care processes.
The prognostic implications of such abnormalities in asymptomatic and moderate cardiovascular risk populations remain to be evaluated.
The prognostic implications of the different geometric patterns have been extensively studied in middle-aged subjects , but data are scarcer for elderly populations.
The prognostic significance , interdependence , and hierarchy of cardiovascular risk factors could evolve with advancing age.
The prognostic significance of PSA nadir and time to PSA nadir on PCSM and ACM were analysed using Kaplan-Meier analysis and the Cox regression model.
The prognostic significance of this finding needs to be determined.
The prognostic value of heart rate variability ( HRV ) in patients with cardiac conditions has been investigated for many years.
The prognostic value of TC and CR in mild SCH should be considered.
The prognostic values of DBP and SBP were assessed by a multivariate Cox regression model and their interactions with ATS examined.
The program comprised @number@ health lectures , @number@ events , and @number@ booths.
The program comprised Pilates exercises for upper- and lower-body strength , agility , and aerobic capacity.
The program goal was to improve skills and facilitate career development.
The program had a duration of @number@ months and a 6-month follow-up period after the intervention.
The program has been met with high patient satisfaction ( @number@ of @number@ ) .
The Program has made rapid autopsy a priority , with a @number@.0-hour median post-mortem interval for the entire collection.
The program is delivered by telephone to increase accessibility and sustainability for caregivers.
The program is designed to cover the @number@ core competencies in the Can MEDS-Family Medicine roles.
The program , Life Enhancing Activities for Family Caregivers : LEAF was conducted in-person or by videoconference with caregivers across the United States.
The programme comprised four exercises , half of them in a standing position , performed at @percent@ of maximum.
The programme consisted of a unique programme of physical activity and health education.
The programmed aging paradigm interprets aging as a function favored by natural selection at a supra-individual level.
The Program of medical and psychosocial care to patients with cancer with positions of personalized medicine was proposed.
The program's @number@ year history was well represented with participants ranging from the first graduating class to current students.
The program's ongoing evaluation is vital and will provide internationally valuable data.
The program's successes and opportunities for improvement are examined , as well as the recommendations for other nursing programs facing issues with student attrition.
The program was also beneficial with respect to cost savings.
The program was developed over @number@ sessions of @number@ min.
The program was independently promoted by the health center team for a further @number@ months post-intervention.
The progress in this line of research is hindered due to the lack of appropriate in vitro models.
The progression group exhibited a higher prevalence of hypertension and greater CIMT compared with the nonprogression group.
The progression in cognitive scores correlated with age and disease duration , but not with nCTG , muscular impairment nor education at baseline.
The progression of AS involves complex inflammatory and fibroproliferative processes that resemble to some extent atherosclerosis.
The progression of cardiovascular disease could be regarded as following atherosclerosis-related and age-related pathways.
The progression of facial shape with aging is the subject of various theories and assumptions but remains poorly understood.
The progression of mild parkinsonian signs in the absence of idiopathic Parkinson's disease in aging is unclear.
The progression of Parkinson's disease was accelerated , and dementia evolved earlier than reported in the younger onset cases.
The progression / resolution of delirium will be monitored.
The progressive accumulation of metabolic waste and damaged organelles in cardiomyocytes blocks the intracellular recycling process of autophagy and increases the cell's propensity toward apoptosis.
The progressive course of Parkinson's disease is clinically characterised by bradykinesia , rigidity and tremor.
The progressive decline of renal function with aging is not inevitable , because it is mainly due to comorbid conditions such as hypertension and diabetes.
The progressive increase in the prevalence of obesity and aging in the population is resulting in increased healthcare and disability spending.
The progressive introduction of blood derived products has greatly improved the prognosis and quality of life of affected patients.
The progressive loss of estrogen and its protective effects , combined with deficient endogenous antioxidant results in oxidative stress.
The progressive loss of muscle strength during aging is a common degenerative event of unclear pathogenesis.
The progress made on the premature aging disorder Progeria is a shining example of the impact that studies of rare diseases can have.
The progress of deformity and GM changes in the fusion mass and the kyphotic curve was documented.
The progress of the disease may be slowed if treatment is administered in accordance with current guidelines.
The pro-inflammatory cytokine LIF governs fibroblast activation in cancer by regulating the myosin light chain @number@ activity.
The proinflammatory phenotype of the microglia suggests that they may negatively affect disease course and contribute to behavioral decline.
The project aims to investigate the association between CSVD and susceptibility loci and candidate genes.
The project descriptions are based on relevant English publications , on-site visits and interviews with developers and users.
The projected adult population growth in the United States from @number@ to @number@ will be @percent@.
The projected growth in organs is highly heterogeneous across different United Network for Organ Sharing regions.
The projected increase in hospitalization and health care needs for this group requires immediate attention.
The projected increase will be driven largely by growth and aging of populations and will be largest in low- and medium-resource countries.
The projected prevalence for @number@ was @number@ million for AF only , @number@ million for AFL only , and @number@ million for AF and AFL.
The project incorporates a developmental action research design in partnership with homeless and formerly homeless women.
The projections indicate that the proportion of the elderly in a few decades will increase significantly.
The project outcomes of current initiatives are consolidated and recommendations for future research in the field of active and assisted living were issued.
The projects are introduced in terms of their basic architecture and implementation , their present status and future objectives.
The project was designed to raise awareness in the general population on major lifestyle behaviors and risk factors for chronic diseases.
The proliferation of A549 was assessed by MTT assay.
The proliferation of gambling opportunities in Canada , coupled with an aging population , has led to an increased prevalence of gambling among older adults.
The proliferation of prostate cancer cells is controlled by the androgen receptor ( AR ) signaling pathway.
The proliferation of these progenitors reduced as a function of gestational age , almost terminating by @number@ gw.
The proliferation rate decreased significantly as passages increased , and the expression of p16 ( INK4a ) mRNA significantly increased.
The proliferation-related proteins examined in this work included glucose-regulated proteins , cytokeratin , and C-myc.
The proliferative arrest suppresses the development of cancer by preventing the propagation of stressed or damaged cells that are at risk for neoplastic transformation.
The proliferative potential of eukaryotic cells is critically dependent upon the maintenance of functional telomeres , the protein-DNA complexes that cap the ends of chromosomes.
The prolonged follow-up period allowed the capture of deep storage lesions.
The prolonged survival time uncovered the development of corneal opacities due to corneal edema.
The prolonged TFPI-mediated anticoagulant levels observed in children administered UFH may contribute to the increased rate of major bleeding reported in children compared to adults.
The prolonged transitions common for White young adults explained racial differences in support of offspring.
The pro-longevity effects of activating AMPK or deactivating calcineurin decrease CRTC-1 and CRH-1 activity and induce transcriptional responses similar to those of CRH-1 null worms.
The prominent PM group was younger , had a higher S ' and lower E / e ' than other groups.
The promising results achieved in the laboratory with animal models have not been replicated with human trails as expected.
The promoter analysis pipeline allows users to investigate the age-dependent regulation of gene expression.
The promoter for the Sdpr gene was determined to be progressively hypomethylated with age.
The promoter region of the FOXA2 gene is completely unmethylated in bronchial cells irrespective of cell culture age and AEDL action.
The promoter region of the MGMT gene was hypermethylated in ARC tissue compared to controls.
The promoter region of the Osx gene encodes two potential binding motifs for XBP1 , and we show that XBP1 binds to these regions.
The promotion of light PA may be a valuable means to maintain cognitive ability in older age.
The promotion of social engagement may be important in preventing institutionalization.
The proof-of-concept of this method was established using prenylated peptides which mimicked the prenyl motifs in the proteins.
The proof of principle was performed with pigmented skins differing only in the fibroblast component.
The proof that Hayflick limit is also caused by the decrease in level of bioenergetics is presented in this article.
The proper cuff size is selected and a blood pressure is obtained using an oscillometric device.
The proper function of a neuron relies on the compartmentalization of their intracellular domains.
The properties of GIRK2 have been shown to be enhanced by the stress peptide corticotrophin-releasing hormone.
The properties of the ODN containing 2-amino-Adap were evaluated by measuring thermal stability and fluorescence quenching.
The proper treatment strategy will have to consider the peculiarities of geriatric patients , so a multidisciplinary approach is mandatory.
The proponents prioritise ideas of intergenerational justice and meritocratic justice based on individual performance , and underline pension-related interest oppositions between age groups and cohorts.
The proportion of abnormal to total white matter volume was estimated using the total volume of the white matter skeleton.
The proportion of CD28-CD57 + cells also remained higher among patients with cancer throughout the sampling duration.
The proportion of CD33 expressed as D2-CD33 correlated robustly with rs3865444 genotype.
The proportion of cerebrovascular disease remained unchanging but the proportion of ischemic heart disease showed a significant increase.
The proportion of CGI-C agitation responders ranged from @number@ to @percent@ and was significantly different from zero.
The proportion of chain-affiliated RCFs grew with increasing facility size.
The proportion of children potentially deficient in essential elements or poisoned by toxic elements was evaluated.
The proportion of deamidation increased from birth to teen-age years and then plateaud.
The proportion of \ "diastolic heart failure \ " is about @number@ to @percent@ of the total number of heart failure patients.
The proportion of drivers with probable cognitive or visual impairments was similar in those who had ABT and those who did not.
The proportion of elderly in the world is increasing , resulting in larger pool of people at risk for Parkinson's disease.
The proportion of elderly people in societies of western industrialized countries is continuously rising.
The proportion of global functional decline exhibited a dose-response curve with increasing levels of IL-6.
The proportion of individuals being unaware of an olfactory dysfunction was high in both middle aged ( @percent@ ) and old ( @percent@ ) participants.
The proportion of life expectancy without diabetes to total life expectancy decreased , indicating a similar development in both.
The proportion of mechanical strength attributable to the peripheral compartment increased with age in both sexes and at both vertebral levels.
The proportion of men receiving non-surgical cosmetic procedures has risen substantially in recent years.
The proportion of MVPA that was vigorous was not associated with weight change.
The proportion of national cardiovascular mortality on total deaths increased annually by @percent@ to @percent@ from @number@ to @number@
The proportion of older people exposed to polypharmacy and hyperpolypharmacy has increased in @number@ compared to @number@
The proportion of older people living in our communities is rising and , to live independently , some require assistance from home care services.
The proportion of older persons assessing their health positively ranged , depending on the studies , from @percent@ to @percent@.
The proportion of outpatients positive for targeted pathogens was analyzed by residential areas and seasonal patterns.
The proportion of paroxysmal atrial fibrillation and non-paroxysmal atrial fibrillation ( persistent or permanent ) patients were @percent@ and @percent@ , respectively.
The proportion of participants living alone differs significantly ( P < @number@ ) across the three age groups.
The proportion of participants receiving polypharmacy was nearly 3-fold greater in @number@ than in @number@ ( @percent@ vs @percent@ ; p < 0.001 ) .
The proportion of patients displaying such α-synuclein and / or ubiquitin intracytoplasmic inclusions was significantly higher with aging.
The proportion of patients suffering from cataracts and frailty is expected to increase , as are age-related diseases.
The proportion of patients taking antihypertensive or antidiabetic medication prior to stroke decreased , whereas the proportion of patients taking lipid lowering medication increased.
The proportion of patients treated with an antiepileptic was higher in case of neuropathic pain.
The proportion of patients who still had one or more PIM at discharge did not differ between groups.
The proportion of patients who were unable to perform the test and the maximal walking distance were obtained.
The proportion of patients with non-specific abdominal pain was significantly lower in patients ≥65years than in their younger counterparts ( p = 0.04 ) .
The proportion of patients with suppressed HIV-1 RNA increased over time.
The proportion of people with prevalent disability who died < 3 years remained stable , as did the survival time of people with incident disability.
The proportion of rheumatic heart disease declined while the proportion of other cardiovascular disease mortality showing a slight change.
The proportion of subjects reporting progression increased with age.
The proportion of temporal length to the entire horizontal diameter was calculated as temporal length / horizontal diameter of PPVP.
The proportion of temporal length to the entire horizontal diameter was @number@ ± @number@ and @number@ ± @number@
The proportion of the Australian population aged @number@ years or more increased from @percent@ in @number@ to @percent@ in @number@
The proportion of the elderly population in most countries worldwide is increasing dramatically.
The proportion of total phosphatidylcholine within the mitochondrial fraction increased within the entorhinal cortex with age , while total mitochondrial phosphatidylethanolamine decreased.
The proportion of under-reporters was @number@ and @percent@ , respectively.
The proportion of visits with elder abuse was estimated using survey weights.
The proportion of white matter in the brain has increased during evolution , and white matter comprises approximately half of the human brain.
The proportion of women diagnosed with MUI varied significantly by definition ranging from @percent@ to @percent@.
The proportion of women , for the same age categories , was @number@ @number@ and @percent@ , respectively.
The proportion of women with low apoA1 levels decreased with age , but the proportion with low high-density lipoprotein levels remained stable across age groups.
The proportion parous across each village ranged between @number@.54-0.58.
The proportions of AKI in the four age groups were @time@ % , @percent@ , @percent@ , and @percent@ , respectively.
The proportions of dementia disorders were similar across HF types.
The proportions of dementia disorders were similar across HF types.
The proportions of osteoarticular infections among patients with both HACO and CA bacteremia were higher than that of patients with HO bacteremia.
The proportions of variance explained by RPE overall , RPE within participant , and RPE within session were only @number@ @number@ and @percent@ , respectively.
The proportion was @percent@ ( @number@ of @number@ ) in patients aged over @number@
The proposed algorithm can be used to automatically label a novel scan with any of the protocols from the training data.
The proposed algorithm was evaluated in a population of @number@ subjects.
The proposed approach supported the significant influence of personal medical history features during an optimal observation period.
The proposed categorization in this chapter can be helpful for usage by patients and their relatives , care givers , and medical doctors.
The proposed causes accented pesticides , especially persistent organochlorines such as DDT.
The proposed classification differentiates between continuous and episodic gait disturbances because this subdivision has important ramifications from the functional , prognostic , and mechanistic perspectives.
The proposed classification for the deviated nose with unilateral cleft lip could serve as a practical guide for surgical planning.
The proposed concepts are hope , health habits , coping with aging , social relations , and active aging.
The proposed conceptual model was validated using a general structural equation model with a logit link function for positive self-rated health.
The proposed framework is applied to a study of diffusion-based connectivity in subjects with autism.
The proposed framework utilizes sensor sequence similarity and NLP on EHR nursing comments to automatically notify the physician when health problems are detected.
The proposed hypothesis has several implications.
The proposed improvements in wine quality arising from MOX include color stabilization , removal of unwanted off-odors , and improvements in wine mouthfeel.
The proposed mechanism may explain the clinical effects of vibratory rehabilitation in neurological patients with motor deficits.
The proposed method has been successfully applied to sulcal parcellation of both real and simulated longitudinal inner cortical surfaces of human brain MR images.
The proposed method is applicable to both cross-sectional and longitudinal region-level imaging data.
The proposed method might provide the means to solve the so far unresolved issue of determining a fingerprints age in forensics.
The proposed methodology is generic in regard to application domains.
The proposed methods are evaluated using simulations.
The proposed methods improve , in terms of mean square error , on the unconstrained estimators.
The proposed method uses PZMs to extract discriminative information from the MR images of the AD , MCI , and HC groups.
The proposed method was robust in the independent sample yielding SI = 0.64±0.17 with ICC = 0.93 for ADNI2 / GO subjects.
The proposed model allows determination of FPA mechanical properties for subjects of any given age in the range of 13-82years.
The proposed model has the potential to help healthcare professionals effectively design and implement their suicide prevention programs.
The proposed model is based on a hypergraph structure , and thus it allows a high-order relationship between contextual nodes and enables incremental learning.
The proposed model was used to predict both cancer incidence rates and counts at the county level.
The proposed new algorithm was based on weighted combination and named as multi-modality SCDDL ( mSCDDL ) .
The proposed relation includes empirical constants which need to be empirically determined.
The proposed solution , i.e. serious games rehabilitation exercises coupled to motion analysis , seems to be an interesting tool to assess global motor function.
The proposed solutions were classified using the Selection , Optimization , and Compensation ( SOC ) model.
The proposed system integrates the tablet PC and GPS to track and to detect the occurrence of abnormal condition off-line.
The proposed technique employs multi-spectrum networks to characterize the complex yet subtle blood oxygenation level dependent ( BOLD ) signal changes caused by pathological attacks.
The proposed trial will determine the clinical and cost effectiveness of the intervention delivered in a UK context.
The proposed underlying anti-aging mechanisms are down-regulated translation , increased autophagy , altered metabolism and increased stress resistance.
The \ \ " proposes that group coordination , arms and fire abolished the survival advantage of lean individuals from predation.
The proprietary product was better tolerated than tretinoin , with fewer subject reported side effects.
The proprotein convertase furin is a potential target for drug design , especially for the inhibition of furin-dependent virus replication.
The pros and cons of our screening method are discussed.
The pro-senescence effect of mutant collagen was blocked by vitronectin , a ligand for αvß3 integrin that is presented by denatured but not native collagen.
The pro-senescent effects of IGFBP4 and IGFBP7 are reversed by single or simultaneous immunodepletion of either proteins from senescent-CM.
The prospect of optimizing FoxO3 activity in humans to increase lifespan and reduce age-related diseases represents an exciting avenue of clinical investigation.
The prospect of space travel continues to capture the imagination.
The prospects for drugs that can deliver at least a subset of the benefits of CR seems very real.
The prostacyclin analogue iloprost is currently recommended in CLI patients for its effects in relieving symptoms by promoting local perfusion.
The prostate is exposed to environmental and endogenous stress that may underlie this remarkable incidence.
The proteasome inhibitor epoxomicin raised ubiquitinated protein levels at least 3-fold higher than the lysosomotropic agent chloroquine.
The proteasome is an enzyme complex responsible for targeted intracellular proteolysis.
The proteasome plays a key role in the maintenance of proteostasis and its failure is associated with various biological phenomena including senescence and aging.
The protection mechanism does not involve simple competition between ADDLs and insulin , but rather it is signalling dependent down-regulation of ADDL-binding sites.
The protection occurred in a dose-dependent manner , with 5μM offering best efficacy.
The protection of the skin against sunlight is the main action to prevent skin cancer and photo-aging.
The protective effect of emotional support was strongest amongst adults aged @number@ years and older.
The protective effect of statins observed among the very old appears to be independent of TC.
The protective effect of tea consumption on HCC development deserves further validation.
The protective effects of 3-deoxysappanchalcone against TNF-α-induced damage was investigated using human skin keratinocytes.
The protective effects of a high AA intake may be dependent on the amount of EPA + DHA intake.
The protective effects of cognitive reserve could contribute differentially in early versus late stages of the disease.
The protective effects of exercise training on cognition may be realized through the enhancement of neural recruitment mechanisms , which may possibly increase cognitive reserve.
The protective influence of greater early childhood height was strongest in those with the lowest systolic blood pressure at @number@ to @number@ years.
The protective potential of melatonin ( MLT ) in Parkinson's disease ( PD ) is the subject of considerable controversy.
The protective role of telomeres depends on various factors , including number of nucleotides repeats , telomere-binding proteins , and telomerase activity.
The protein aggregates formed at the cell periphery are delivered along the microtubulus network by dynein-dependent retrograde trafficking to a juxtanuclear location.
The protein carbonylation of erythrocyte membrane was positively correlated with plasma RCS concentration ( p < @number@ ) , but not plasma thiols concentration.
The protein contains an ubiquitin-binding zinc finger ( UBZ ) domain at the N terminus and an ATPase domain in the middle region.
The protein deacetylase SIRT1 , and its activator resveratrol , exert beneficial effects on glucose metabolism.
The protein deacetylase SIRT1 regulates various pathways in metabolism , aging and cancer.
The protein displaying the most pronounced UVA-induced upregulation was identified as the nucleolar protein nucleophosmin.
The protein isoform is suggested to be secreted.
The protein is shed and circulates.
The protein LC3 is indispensible for the cellular recycling process of autophagy and plays critical roles during cargo recruitment , autophagosome biogenesis , and completion.
The protein levels , gene expression and methylation status of Nrf2 / Keap1 were investigated in human lenses from different age groups.
The protein levels of complement C1q and C3 were analysed by Western blotting.
The protein levels of two mediators for DNA damage induced-senescence , p16 and p21 , were examined by western blotting.
The protein levels were determined by Western blot analysis.
The protein-ligand docking pipeline provides information on the position and orientation of a ligand in an age-related protein surface.
The protein L-isoaspartyl ( D-aspartyl ) methyltransferase ( PIMT ) is an enzyme that recognizes and repairs the abnormal L-isoaspartyl residues in proteins.
The protein mutated in Huntington disease ( HD ) , mutant huntingtin ( mHtt ) , is expressed throughout the brain and body.
The proteins act within most intracellular compartments and span the molecular determinants of firing and wiring in the developing brain.
The proteins Atg6 ( Beclin @number@ ) and Pi3K59F are involved in autophagosome formation , a key step in the initiation of autophagy.
The proteolytic activity of cysteine cathepsins is controlled by endogenous protein inhibitors-the cystatins-which evidently fail to perform their function in neurodegenerative processes.
The protocol allowed sensitive and selective precursor ion scans to detect the modified peptides in complex sample mixtures.
The protocol consisted of a detailed interview , visual acuity ( VA ) testing , and clinical examinations.
The protocol consisted of both active-assisted cycling and resistance training.
The protocol for this review was registered on PROSPERO ( CRD42016032905 ) .
The protocol here would provide an effective method to perform a wide range of studies to understand the mechanisms of cardiac diseases in humans.
The protocol is illustrated with the example of color vision , but is generally applicable to any form of visual adaptation.
The protocols for juvenile toxicity studies are devised in consultation with the FDA or EMEA.
The protocol takes ∼2-4 d , including the generation of standards.
The protocol was pre-specified ( PROSPERO CRD42015023731 ) .
The protocol was registered at Clinicaltrials.gov ( NCT02103075 ) .
The protocol was repeated 24h later with the alternative preparation.
The proto-oncogene c-Myc is vital for vascular development and promotes tumor angiogenesis , but the mechanisms by which it controls blood vessel growth remain unclear.
The proto-oncogenes NTRK1 / @date@ encode the tropomyosin receptor kinases TrkA / B / C which play pivotal roles in neurobiology and cancer.
The prototypes of the proposed concepts in this paper have been tested with elderly people.
The provided overview could be used to create fall preventive measures for elderly.
The provided results showed that with age , women tended to have better diet.
The provision and receipt of emotion work-defined as intentional activities done to promote another's emotional well-being-are central dimensions of marriage.
The provision of nutrition has traditionally been driven by the desire to provide adequate calories.
The provision of pharmaceutical care , medication reviews and educational interventions by pharmacists in the nursing home , ambulatory and acute care settings are discussed.
The provision of reasonable alternatives and / or certification of approved supplements by the U.S. Department of Defense would be prudent.
The provision of skilled nursing services did not vary by facility size.
The provocative effects of NPA tasks were more prevalent in photosensitive cases , especially the tasks of action-programming type ( p = 0.04 ) .
The proximal esophageal contractions were recorded @number@ cm from a pharyngeal recording site located @number@ cm above the upper esophageal sphincter.
The proximal humerus not only forms the lateral portion of the shoulder articulation but also has significant associations with musculoskeletal and neurovascular structures.
The proximal landing zone was longer than @number@ cm.
The PR was significantly higher in women < 35 years of age or with < 3 years of unexplained primary infertility.
The p.S85C MATR3 variant was previously associated to a different phenotype , namely a distal myopathy associated with dysphagia and dysphonia.
The PSA rises were related to the stimulation strength of the procedures.
The PS externalization provides a signal for phagocytes to initiate uptake of apoptotic cells.
The psoriatic lesions were treated with calcipotriol ointment.
The PST group experienced a decline in depression scores compared with the social contact group.
The PST-HC group generally reported more favorable satisfaction with treatment than the control group.
The Psy-BBBABSG first milestone is the collection of @number@ brains each of BD and OCD patients , and matched controls.
The psycholinguistic relevance of each dimension , their measures and the correlations among them are provided and discussed.
The psychological aging scale for healthy people included @number@ dimensions as follows : cognitive function , emotion , personality and motivation.
The psychological and cultural features of redemptive life stories are considered , as are the problems and potentialities of life-narrative research in psychological science.
The psychological and physical consequences of bereavement are well established , and the consequences are more severe for mothers than fathers.
The psychological and physical health of this prison population was poorer than that of their community-based peers.
The psychological domain had the highest effect size.
The psychological impact of an adverse life event was assessed based on the Psychosocial Stress Questionnaire.
The psychological present is a diverse psychological phenomenon , including the perception and evaluation of time , which has been studied from different perspectives.
The psychological questionnaire results showed that the bereaved had significantly greater depressive and anxiety symptoms than the non-bereaved.
The psychological status of the patients was evaluated with the help of the Well-being-Activity-Mood test.
The psychometric properties of the proposed OLQ-11 , obtained by deleting the two items , were better.
The psychometric properties of the SGRQ were examined using Rasch model analysis with a mixed rating scale and partial credit mode by Winsteps software.
The psychosocial model of music in dementia was developed.
The psychosomatic approach arose in antiquity as mankind looked for explanations for illness and death.
The psychotherapeutic group \ "@number@ plus \ " provides a supportive group intervention for physically and psychically impaired patients in their second half of life.
The p-tau increased marginally more in patients with PD than in HC. α-syn remained relatively stable in patients with PD and HC.
The PTA values of Stoccareddo and Carlantino are statistically different from PTAs of the other villages.
The PTH peptides significantly stimulated proliferation of hMSCs.
The public and all professionals report a very high level of general support for care provided in a caring and respectful manner.
The public expenditure is mostly for drugs and cash-for-care benefits.
The publicly released labels will allow the widespread implementation of the standard segmentation protocol.
The public , patients , and trainees need the medical education enterprise to improve training and outcomes now.
The published BIA equations proved to be inaccurate and had significant bias.
The published data on sarcopenia are vast , and this review is not intended to be exhaustive.
The published use of MAL-PDT for photorejuvenation is more limited.
The puborectal component of the levator ani muscle defined the levator hiatus boundary.
The pulp response time was measured in seconds and the pain intensity was assessed by visual analogue scale.
The pulp sensibility test was performed with a refrigerant spray.
The pulse pressure is significantly higher at the over sixty-five group.
The pulse pressure levels of women were lower than those of men in early adulthood and higher in older ages.
The pulse pressure was calculated as the difference between the systolic and diastolic brachial blood pressure.
The purified yam tuber's major water-soluble protein , dioscorin , and its protease hydrolysates have been reported to have several biological activities.
The purity of resulting fractions was checked by transmission electron microscopy.
The purported modulatory roles of children's working memory , attentional capacity , or focus preferences require further investigation.
The purpose is to analyze the socio-demographic and clinical profile associated with skin and wound care in hospitalized elderly.
The purpose of care and management for diabetes mellitus is a prevention of chronic complications and maintaining longevity and quality of life.
The purpose of our article is to assess the latest developments in neurotransmitters research using cell and mouse models of AD.
The purpose of our article is to highlight recent advancements in miRNAs and their involvement in cellular changes in aging and senescence.
The purpose of our article is to highlight recent advancements in the regulatory role of miRNAs in OS-induced cellular senescence.
The purpose of our study was to evaluate IOP changes during laparoscopic or robotic hysterectomy conducted in the steep Trendelenburg position.
The purpose of our study was to examine the cognitive and psychosocial factors associated with self-rated health.
The purpose of our study was to identify microRNAs ( miRNAs ) as early detectable peripheral biomarkers in Alzheimer's disease ( AD ) .
The purpose of our study was to use a qualitative approach to examine what perceptions community-dwelling rural older adults have regarding their health.
The purpose of sun-safety behavior is not to avoid outdoor activities , but rather to protect the skin from detrimental sun effects.
The purpose of the current study is to determine whether asymmetries in intralimb coordination are also reduced during the aging process.
The purpose of the current study is to examine a construct that motivates involvement in activities-finding interests in life.
The purpose of the current study was to describe gait performance in different age groups while wearing an age simulation suit.
The purpose of the current study was to evaluate the action of 15-epi-LXA4 in the endothelium viability of human corneas stored in Optisol-GS.
The purpose of the current study was to examine the impact of driving anxiety on young older adults ' health and well-being.
The purpose of the current study was to validate the proposed latent structure of the ACS psychometric battery.
The purpose of the present article was to review empirical research on the factors associated with body dissatisfaction and disordered eating in middle-aged women.
The purpose of the present investigation was to determine if the naturally occurring hormone aldosterone ( ALD ) could regulate NKCC1 protein expression.
The purpose of the present larger , randomized double-blind study was to determine whether a longer period of DHEA replacement improves glucose tolerance.
The purpose of the present research was to clarify the efficacy of @number@ different bisphosphonates against hip fracture in elderly patients with these neurologic diseases.
The purpose of the present review is to summarize evidence for bilingualism as a reserve variable against AD and discuss potential underlying neurocognitive mechanisms.
The purpose of the present review is to summarize the recent progress in the mechanisms underlying autophagy activation during ischemia and preconditioning.
The purpose of the present study was to assess whether the association between sleep duration and mortality varies with age.
The purpose of the present study was to clarify the efficacy of interventions against hip fractures in patients with Alzheimer's disease.
The purpose of the present study was to determine the relationship between serum Klotho ( sKlotho ) and the presence of CVD in dialysis patients.
The purpose of the present study was to determine whether vestibular control of standing balance is altered with adult aging.
The purpose of the present study was to elucidate the relationship of 12S rRNA gene polymorphisms and age-related hearing loss.
The purpose of the present study was to estimate MI performance in older adults , taking into account task requirements.
The purpose of the present study was to evaluate the reliability of the measurements and the performance of hand grip strength dynamometers in the elderly.
The purpose of the present study was to evaluate the shortened telomere as a potential biomarker for tumorigenesis in gastric carcinoma.
The purpose of the present study was to examine communities ' age-friendliness and its relationship to health-related outcomes in a rural context.
The purpose of the present study was to examine these relationships in a group of community-dwelling cognitively normal older adults.
The purpose of the present study was to explore the impact of in-home service utilization on institutionalization.
The purpose of the present study was to explore the relationship between circulatory melatonin level and the extent of senile cataracts.
The purpose of the present study was to investigate serum MLT levels in unilateral 6-hydroxydopamine ( 6-OHDA ) lesion rats and patients with PD.
The purpose of the present study was to investigate the relationship between the age-related loss of thigh muscle , muscle function and gait performance.
The purpose of the present study was to provide new norms for the a-BT as part of the Neuronorma project.
The purpose of the present study was to validate this pressure-independent index for aortic stiffness in humans.
The purpose of the present work was to find new anticancer molecules from a natural source.
The purpose of the project was to theorize key dynamics of livability for older adults who are aging in place in their homes and communities.
The purpose of the study was to compare the prevalence of diabetes and cardiometabolic conditions in a Manitoba First Nation between @number@ periods.
The purpose of the study was to compare young old normal PNIF values with older old normal PNIF values.
The purpose of the study was to determine factors related to DDT performance in a large cohort spanning the adult age range.
The purpose of the study was to determine if syntactic complexity would show an age-related decline.
The purpose of the study was to examine predictors of the leg hemodynamic response to exercise in middle- and older-aged men and women.
The purpose of the study was to examine the relationship between CRF and cognition in young and OA and whether CRF mitigates age-related cognitive decline.
The purpose of the study was to explore the specialized supportive mobility needs of community-residing older adults.
The purpose of this article is 2-fold.
The purpose of this article is to assess whether midface lifting based on purely vertical repositioning constitutes an effective procedure for its correction.
The purpose of this article is to consider hints that crosswords provide and questions that they prompt regarding how the mind works.
The purpose of this article is to describe @number@ cases of patients with FTD to illustrate salient aspects of the caregiving experience.
The purpose of this article is to discuss current techniques used with poly-l-lactic acid to safely and effectively address changes observed in the aging face.
The purpose of this article is to draw attention to this topic and highlight some of the critical issues , gaps , and opportunities.
The purpose of this article is to highlight how to interpret these deficits within the framework of neuroplasticity and cognitive reserve for this clinical population.
The purpose of this article is to provide a narrative review of current technology appropriate for older adults ' home use.
The purpose of this article is to provide clinicians with practical input about therapeutic issues and interventions for use with TGNC elders.
The purpose of this article is to provide older adults ' sex-and-age-specific normative values for accelerometer-determined steps / day , adjusted to a pedometer-based scale.
The purpose of this article is to report the influence of gender on aging with childhood onset paralytic polio.
The purpose of this article is to review existing peer-reviewed literature supporting the concept of restoration of endogenous testosterone in the treatment of LOH.
The purpose of this article is to review how ROS signaling leads to the activation of TGF-β.
The purpose of this article is to review minimally invasive surgical options for the treatment of osteoarthritis of the hip , knee , and shoulder.
The purpose of this article was to assess the reliability , construct and convergent validity of the LSA in Latin American older populations.
The purpose of this article was to evaluate the efficacy and safety of PAE on LUTS related to BPH.
The purpose of this article was to review the empirical literature that investigated trauma and stress among older adults in the criminal justice system.
The purpose of this chapter is to discuss how frailty is conceptualized and operationalized based on these two approaches.
The purpose of this chapter is to summarize some studies that compared these most commonly used frailty definitions.
The purpose of this cross-sectional study was to investigate the association between carotid artery PI , cardiovascular risk and ischaemic heart disease in aging women.
The purpose of this current opinion is to provide an evolutionary overview of sarcopenia research since @number@
The purpose of this exploratory study was to characterize the memory experiences and concerns of AL residents.
The purpose of this exploratory study was to examine telomeric DNA length in women who have experienced chronic stress related to IPV.
The purpose of this exploratory study was to investigate factors that influence depression among older Korean immigrants in Toronto.
The purpose of this investigation attempts to clarify these issues.
The purpose of this investigation is to assess the effects of age on peak VO ( @number@ ) in HF patients taking b-blockers.
The purpose of this investigation was to compare pharyngeal wall thickness at rest and when maximally constricted during swallow in younger and older adults.
The purpose of this investigation was to determine body composition classification using field-based testing measurements in healthy elderly men and women.
The purpose of this investigation was to determine the role of activation intensity requirements of the thigh musculature in limiting a multi-joint STS endurance task.
The purpose of this next phase is to perform a longitudinal follow-up 6-months postintervention.
The purpose of this paper is to clarify the age-associated changes in walking movements.
The purpose of this paper is to describe aspects of optimal aging from the perspective of the Neuman systems model.
The purpose of this paper is to propose a fast reconstruction framework that combines a CS-based reconstruction algorithm with several speed-up techniques.
The purpose of this paper is to review current promising drugs that are being evaluated in clinical trials.
The purpose of this paper was to describe the data collection methods and report preliminary population estimates for each measures.
The purpose of this paper was to investigate whether young and older adults adapt to lower lip perturbations during speech differently.
The purpose of this pilot study was to examine the relationship between health literacy and self-care of patients with heart failure.
The purpose of this project was to improve dysphagia-screening processes in a tertiary Veterans Affairs Medical Center.
The purpose of this qualitative study was to provide in-depth descriptions of preferences for receipt of long-term care among a small sample of information-rich cases.
The purpose of this research was to evaluate healthy older adults ' interest and participation in a dance game adapted for an older user.
The purpose of this research was to investigate the mechanisms of antiplatelet action of Cyperus digitatus.
The purpose of this review is to analyze the developments in the area during the last @number@ years.
The purpose of this review is to assess the health effects of chronic tea and / or coffee consumption.
The purpose of this review is to describe how crystals could influence cartilage biomechanics and mechanotransduction in osteoarthritis.
The purpose of this review is to describe the details of this mechanism to better direct future research.
The purpose of this review is to describe the role of protein and exercise in slowing the progression of sarcopenia.
The purpose of this review is to examine emerging knowledge on morbidity and mortality in sarcoidosis.
The purpose of this review is to examine lung cancer in relation to oxidative stress , physical activity , and nutrition.
The purpose of this review is to identify and highlight the areas of telerehabilitation that require the most research attention.
The purpose of this review is to provide a clear description of the current strategies for diagnosis and management of TD.
The purpose of this review is to provide a comprehensive update on the genetic causes of frontotemporal lobar degeneration ( FTLD ) .
The purpose of this review is to provide a current overview of bond strength testing methods and their applicability to the characterization of dental adhesives.
The purpose of this review is to stimulate further research to identify new strategies to prevent or treat age-related lung disease.
The purpose of this review is to summarize and compare existing criteria to enable more informed choices about their use.
The purpose of this review is to summarize the epidemiological evidence underpinning the association between blood pressure and a range of conditions.
The purpose of this review , therefore , is to define a measured position in relation to the use of this drug.
The purpose of this review was to assess the effects of climate change and consequent increases in environmental heat stress on the aging cardiovascular system.
The purpose of this review was to identify the cognitive domains that are significantly associated with falls or falls risk in older adults.
The purpose of this review was to summarize known findings related to exposure of aged and diseased kidneys to the environmentally relevant nephrotoxicant Hg.
The purpose of this scoping review was to examine the empirical evidence published since @number@ on men as family caregivers of persons with dementia.
The purpose of this secondary study was to describe the mobility adaptations of community-living older adults.
The purpose of this study is to analyze the influence of a cognitive training program on @number@ subjects with age-related memory loss.
The purpose of this study is to assess social and health related factors of self-reported health among the elderly in Ghana.
The purpose of this study is to clarify the association between platelet activation and aging or atherosclerosis.
The purpose of this study is to compare the clinical outcomes of LLR versus OLR for HCC in elderly patients.
The purpose of this study is to compare the clinical outcomes of these two several approaches in elderly patients.
The purpose of this study is to demonstrate the predictive validity of the CIB for discharge location among a sample of older medical inpatients.
The purpose of this study is to elucidate the cross-sectional profile of patients affected by sIBM in Japan.
The purpose of this study is to establish a relevant mouse model of LF hypertrophy and to examine disease-related factors.
The purpose of this study is to evaluate the feasibility of using ethnodrama as an intervention to highlight late-life potential.
The purpose of this study is to evaluate the mechanism of postural control in the M / L direction in the elderly.
The purpose of this study is to examine how social factors in the church influence the decision to volunteer.
The purpose of this study is to examine the effects of a speed or accuracy strategy on response interference control during choice step execution.
The purpose of this study is to examine the effects of the selected non-pharmacological lifestyle activities on the delay of cognitive decline in normal aging.
The purpose of this study is to examine the relationship between selenium level and hypertension in a rural elderly Chinese cohort.
The purpose of this study is to explore the effectiveness of Jingui external lotion for the management of painful knee osteoarthritis in a short-term study.
The purpose of this study is to explore the phenomenon of detention of persons suffering from dementia.
The purpose of this study is to identify the psychosocial factors influencing healthy aging and examining their socio-demographic characteristics.
The purpose of this study is to investigate reliability and validity of the Persian translation of BBS in Parkinson disease.
The purpose of this study is to investigate the effect of the Life Review Program-Taiwan ( LRP-TW ) on outpatients with mild to moderate dementia.
The purpose of this study is to investigate the role of non-canonical EGFR pathway in resistance mechanism against cisplatin treatment.
The purpose of this study is to investigate whether aging changes the QT dispersion in the very old.
The purpose of this study is to observe the efficacy and safety of the protocol ' ActiveFX ' for photodamaged facial skin in Chinese patients.
The purpose of this study is to present an age and gender normative values for static back extensor muscles ' endurance in adults.
The purpose of this study is to qualitatively and quantitatively describe the morphology of the biceps insertion on the radial tuberosity.
The purpose of this study is to review the current literature regarding the control of physical activity levels by the sex hormones in humans.
The purpose of this study is to see if encouragement from fellow church members helps older people develop and maintain healthy lifestyles.
The purpose of this study is to test a novel hearing intervention for persons with dementia and family caregivers delivered in outpatient settings.
The purpose of this study , therefore , was to determine whether the motor plan differs for young and older adults.
The purpose of this study was to analyze the incidence of delirium in patients undergoing orthopedic surgeries and to explore possible related factors.
The purpose of this study was to assess perspectives among prefrail and frail , middle-aged and older homeless women.
The purpose of this study was to assess TBK and BCM in healthy men over a 21-year period , and to evaluate changes with age.
The purpose of this study was to assess the biological organ age of liver grafts.
The purpose of this study was to assess the correlation of skin colour and tooth shade.
The purpose of this study was to assess the effect of a moderate intensity exercise program on markers of oxidative stress in older age adults.
The purpose of this study was to assess the preclinical therapeutic efficacy of FUS-BBB opening for enhanced temozolomide ( TMZ ) delivery in glioma treatment.
The purpose of this study was to assess the relation between specific foot disorders , foot posture , and foot function.
The purpose of this study was to assess whether autonomic nervous activity assessed by HRV contributes to AF termination.
The purpose of this study was to better estimate the fusion timeline of the synchondroses at the CVJ.
The purpose of this study was to better understand adjustment and life satisfaction in later life.
The purpose of this study was to characterize age-related alterations and functional consequences of mTOR signaling in the postmitotic RPE cells.
The purpose of this study was to characterize quadriceps femoris muscle fatigue of both lower extremities in patients with knee osteoarthritis ( OA ) .
The purpose of this study was to characterize the distribution of intramyocellular lipid content and to determine its association with disease characteristics.
The purpose of this study was to clarify age-related changes in the elastic properties and moisture content of the lower labial mucosa.
The purpose of this study was to compare odor identification performance among Polish subjects and to define the correlation between olfactory deficits and cognitive impairment.
The purpose of this study was to compare spring-mass behavior between older and younger individuals at a range of hopping frequencies.
The purpose of this study was to compare the comfortable pace gait kinematics of older AT practitioners with those of healthy , age-matched controls.
The purpose of this study was to compare the most important life events reported by U.S. and Japanese centenarians.
The purpose of this study was to conduct a systematic review to determine the risk of pneumococcal infections in celiac disease.
The purpose of this study was to construct an integral formula of the BA , by using principle component analysis ( PCA ) .
The purpose of this study was to define risk factors of AAA and AIOD in the Polish population and indicate differences between diseases.
The purpose of this study was to describe income-related inequalities in dental service utilization by the elderly populations residing in different European countries.
The purpose of this study was to determine how aging , with and without hypertension , affects left ventricular function.
The purpose of this study was to determine how closely associated these commonly used biochemical measures are to muscle mitochondrial content and OXPHOS.
The purpose of this study was to determine how the spinal canal of the lumbar spine changes with age.
The purpose of this study was to determine if aging was associated with reduced ability of forward reach or changes in movement patterns.
The purpose of this study was to determine if children transmit vibration differently than adults while standing on a vibration platform.
The purpose of this study was to determine if economic status in late life is associated with cognition independent of socioeconomic status in early life.
The purpose of this study was to determine if there are differences in cognitive decline among racial and ethnic older adults.
The purpose of this study was to determine if these gender differences are also noted within a pediatric population.
The purpose of this study was to determine reference thresholds above @number@ kHz.
The purpose of this study was to determine the association between spine bone mineral density ( BMD ) and vascular and valvular calcification.
The purpose of this study was to determine the early and late-onset expression of various vascular markers in a rodent model of depression.
The purpose of this study was to determine the influence of age on the acute viscoelastic responses to a practical stretching intervention.
The purpose of this study was to determine the key determinants of loneliness of older Canadians.
The purpose of this study was to determine the relative contribution of selected neuromuscular and biomechanical variables associated with balance recovery to the MRLM.
The purpose of this study was to determine what role aging and optical blur play in stereoscopic disparity sensitivity for real depth stimuli.
The purpose of this study was to determine whether age affects the adjustment of cognitive control following a conflict.
The purpose of this study was to determine whether balance confidence differed between future fallers and non-fallers , and whether the construct prospectively predicted falls.
The purpose of this study was to determine whether CKD is associated with cognitive impairment among nonagenarians and centenarians in China.
The purpose of this study was to determine whether pharmacokinetic indices for vancomycin are associated with mortality from MRSA hospital-acquired pneumonia in elderly patients.
The purpose of this study was to determine whether ultrastructural changes in intramyocellular lipid ( IMCL ) and mitochondria occur with aging.
The purpose of this study was to determine which functional test best discriminates between elderly women with low and high concern about falls.
The purpose of this study was to develop and test a connectedness scale for older adults.
The purpose of this study was to develop and test a semantic differential scale of sexual attitudes for older people in Korea.
The purpose of this study was to elucidate age-related changes in IVC diameter using echocardiography.
The purpose of this study was to elucidate the relative importance of staff factors associated with sense of competence.
The purpose of this study was to elucidate using time series analysis age and menopause induced differences in selected health quality related physiological factors.
The purpose of this study was to evaluate the association between oxidative stress parameters with a more valid and reliable method in patients with NPs.
The purpose of this study was to evaluate the effect of habitual endurance exercise on muscle mass and strength in active older adults.
The purpose of this study was to evaluate the efficacy of aggressive surgical treatment in managing uncontrollable elevated intracranial pressure coupled with early skull reconstruction.
The purpose of this study was to evaluate the metabolic processes in women with diabetes mellitus type @number@ of different age groups.
The purpose of this study was to evaluate the outcomes after a minimum of @number@ years , and to document prosthetic survival and complications.
The purpose of this study was to evaluate the physiological basis for sex-differences in exercise-induced dyspnea in patients with mild COPD.
The purpose of this study was to evaluate the relationship between clinical symptoms of osteoporotic vertebral fractures with intravertebral cleft and radiographic findings.
The purpose of this study was to evaluate the responsiveness of the PMS using residents of a long-term care facility.
The purpose of this study was to evaluate the role of perceived well-being in obese and overweight older adults.
The purpose of this study was to evaluate women's knowledge of the implications of delaying pregnancy.
The purpose of this study was to examine adult age differences in the distribution of IOR to multiple locations.
The purpose of this study was to examine arterial stiffness and blood flow adaptations to high-intensity resistance exercise training in young and older women.
The purpose of this study was to examine differences in center of mass movement strategies and lower extremity joint kinetics in the elderly during sit-to-walk.
The purpose of this study was to examine if differences in symptoms of CIMD exist when induced in the menstrual cycle follicular or luteal phase.
The purpose of this study was to examine possible relationships between personality , burnout level , longevity , and demographic variables among professional music therapists.
The purpose of this study was to examine proverb interpretation performance and functional independence in older adults.
The purpose of this study was to examine the accuracy of application-based hearing screening in an elderly population.
The purpose of this study was to examine the age-related site-specific muscle loss of the upper and lower extremities and trunk in men and women.
The purpose of this study was to examine the association between C reactive protein ( CRP ) and depressive symptoms in an elderly Korean population.
The purpose of this study was to examine the association between PA and the home environment in well-functioning older community-dwelling persons.
The purpose of this study was to examine the association between total and differential WBC counts and incident CHD in an elderly Japanese-American population.
The purpose of this study was to examine the effect of age on behavioral and physiological measures of frequency representation.
The purpose of this study was to examine the impact of physical geographic factors and climate conditions on human longevity.
The purpose of this study was to examine the predictive factors associated with this antibody titer elevation.
The purpose of this study was to examine the relationship between mobility and plantarflexor muscle-tendon properties in healthy older adults.
The purpose of this study was to examine the relationship between the amount of physical activity and oxidised LDL in older adults.
The purpose of this study was to examine the role of SIRT6 in human chondrocytes by inhibiting SIRT6 in vitro.
The purpose of this study was to examine the sex-specific association between muscle weakness and incident diabetes in older Mexican Americans.
The purpose of this study was to examine the time of onset , the rate , and predictors of menopausal bone loss.
The purpose of this study was to examine what happens to goals over the course of a physical activity counseling trial in older veterans.
The purpose of this study was to examine whether a cognitive training intervention leads to significant improvements on measures of balance and gait.
The purpose of this study was to explore how food preferences varied depending on gender and ethnic groups.
The purpose of this study was to explore social work students ' interest in gerontology.
The purpose of this study was to explore the subjective experience of older adults interacting with both virtual and real environments.
The purpose of this study was to explore whether Sirt1 is involved in the action of Ginsenoside Rb1 regarding protection against H2O2-induced HUVEC Senescence.
The purpose of this study was to find a practical FOG detection system.
The purpose of this study was to find the associations between complications and attributable death.
The purpose of this study was to identify clinical predictors for VT achievement in patients with intermittent claudication.
The purpose of this study was to identify in the scientific literature , the self-image and representations that elders have about themselves in different contexts.
The purpose of this study was to identify prevalence and risk factors of social isolation in older Malaysians.
The purpose of this study was to identify system-wide factors contributing to falls in community-dwelling octogenarians.
The purpose of this study was to identify the frequency of and risk factors of masked hypertension in Korean workers.
The purpose of this study was to identify the hydration status of elite young athletes of different sports , during a typical day of training.
The purpose of this study was to identify these patterns in different age groups.
The purpose of this study was to investigate age differences in offset analgesia of heat pain in healthy younger and older adults.
The purpose of this study was to investigate age-related differences in short-term training adaptations in cortical excitability and inhibition.
The purpose of this study was to investigate color stability of pigmented and nonpigmented maxillofacial silicone elastomer exposed to different human and environmental aging conditions.
The purpose of this study was to investigate gender differences in the associations of life satisfaction with family and social relations among the Japanese elderly.
The purpose of this study was to investigate how hearing and vestibular function in this disease change with aging.
The purpose of this study was to investigate recent changes in the geographic distribution of pediatricians and the factors underlying this change.
The purpose of this study was to investigate the age-related changes in multiple intra-orbital structures using quantitative MRI ( qMRI ) .
The purpose of this study was to investigate the association between LTL and MetS.
The purpose of this study was to investigate the clinicopathological features and treatment approaches of patients with BC aged @number@ years or over.
The purpose of this study was to investigate the differences in foot kinematics between young and older adults during walking using a multi-segment foot model.
The purpose of this study was to investigate the effect of metabolic syndrome on CAVI.
The purpose of this study was to investigate the effects of aging on the cVEMP and on the sternocleidomastoid muscle EMG level.
The purpose of this study was to investigate the effects of sex , age and their interactions on hip abductor muscle properties.
The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults.
The purpose of this study was to investigate the immunophenotyping characteristics of adult acute lymphoblastic leukemia ( ALL ) patients in groups of different ages.
The purpose of this study was to investigate the in vivo IGF-I stimulation of tendon protein synthesis in elderly compared with young men.
The purpose of this study was to investigate the link between subjective cognitive and sleep complaints in a population aged @number@
The purpose of this study was to investigate the molecular pathways involved in RPE death induced by exogenous ROS , especially at higher concentrations.
The purpose of this study was to investigate the neuropsychological profile among older males with the premutation who are at risk for FXTAS.
The purpose of this study was to investigate the predictors of improved functional outcome after rehabilitation of elderly inpatients.
The purpose of this study was to investigate the regularity of movement in individuals with PD , and the effect of dopaminergic medication.
The purpose of this study was to investigate the relationship between BCAA metabolism and IS in overweight ( OW ) individuals during exercise intervention.
The purpose of this study was to investigate the relationship between these morphological measures and the aging effects on these structures.
The purpose of this study was to investigate the relationships between breakfast skipping and obesity prevalence among elderly.
The purpose of this study was to investigate the role of miR-125b in the development of age-related cataract.
The purpose of this study was to investigate these different aspects in a large cohort of patients with this disorder.
The purpose of this study was to investigate the self-rated burden associated with mental health conditions among caregivers.
The purpose of this study was to investigate the surgical treatment of HCTs and their effect on dynamic tibiofemoral contact mechanics.
The purpose of this study was to observe exercise training-induced effects on adiponectin , leptin , and ghrelin.
The purpose of this study was to propose more precise results for these issues using a large sample size.
The purpose of this study was to provide a first test of this hypothesis.
The purpose of this study was to provide a more complete picture of age-related differences in attachment anxiety and avoidance.
The purpose of this study was to provide normative data for an elderly population living in Spain.
The purpose of this study was to quantify manual wheelchair use by nursing home residents.
The purpose of this study was to study the effects of ageing on fibre orientation and strength of the lumbar extensor muscles.
The purpose of this study was to synthesize internal consistency ( Cronbach's alpha ) and test-retest reliability for the AMS scale and its three subscales.
The purpose of this study was to test the hypothesis that sex modulates the FMD response to acute aerobic exercise in older adults.
The purpose of this study was to test the reserve hypothesis in the association between WMH severity and cognition.
The purpose of this study was to understand how best practices related to older adults are spread within home care organizations.
The purpose of this study was to understand the health and safety risk factors for HHCW.
The purpose of this study was to use an arterial spin labeling dynamic magnetic resonance angiography technique to characterize intracranial hemodynamics before and after CEA.
The purpose of this systematic review and meta-analysis was to determine if orthogeriatric collaboration models improve outcomes.
The purpose of this systematic review was to synthesize current findings on the association between loneliness and cognitive function in older adults.
The purpose of this work was to characterize those transcripts in eight patients affected with HGP-like rare syndromes.
The purpose of this work was to examine the dependence of human cerebellar mass and its age dynamics on the body length and body-build type.
The purposes of this study were to investigate calcium scores in offspring as compared to controls and to determine the influence of cardiovascular risk factors.
The purpose was to describe the phenomena of negotiating reliance on canes and walkers as walking devices and the lifeworld context underlying each phenomenon.
The purpose was to develop a reliable and valid Toddler NutriSTEP.
The purpose was to evaluate the clinical validity of these requirements in older hospitalized patients with pressure ulcers by assessing nutritional status and wound healing.
The purpose was to review the translucency of human teeth and related dental materials that should be considered for the development of esthetic restorative materials.
The push to use marine reserves for managing pelagic and demersal species poses significant questions regarding their utility for highly-mobile species.
The putamen , lingual , and so on demonstrated stronger activation during dominant hand MI in the older group.
The putamen , nucleus accumbens and hypothalamus were found with significant interaction between two SERT gene polymorphisms ( SERT-LPR and VNTR ) .
The putative procognitive actions of 5-HT6 agonists are also reviewed.
The putative role and use of dehydroepiandrosterone ( DHEA ) as replacement therapy for menopausal women has been under consideration during the latest years.
The P-value for all samples combined was @number@ and the odds ratio @number@ ( @percent@ confidence interval @number@.96-13.4 ) .
The PWV-by-race interaction was significant in women and analyses are reported separately by race.
The QCZ NPs had an average diameter of 10nm and prominent yellow emission under UV irradiation.
The QEI and EI of the four quadriceps portions were calculated by ultrasound imaging.
The QI set demonstrated excellent inter-rater reliability and good feasibility.
The QKI isoforms are known to regulate RNA metabolism within oligodendrocytes , however , little is known about their roles during cellular stress.
The Qmax was @number@ ± @number@ ml / s , RUV measured by B-Ultrasound was @number@ ± @number@ ml.
The QOL reached about @percent@ of maximum result value , showing equal levels in its specific areas.
The QoL was assessed using the latest version of the audit of diabetes-dependent quality of life ( ADDQoL ) .
The QOL was explored with multiple linear regression analysis.
The QRS duration was not correlated with LV systolic function ( P = @number@ ) .
The quadratic effect appears to be unique to Aβ42 , as Aβ38 and Aβ40 showed only positive linear relationships with age and CSF tau.
The quadratic relationships showed stride length decreased with very high cadences.
The quadriceps muscles were more susceptible to age-related atrophy compared with other thigh muscles.
The quadriceps seems relatively more affected by ageing than other thigh muscles.
The quadripulse stimulation with 5-ms inter-pulse interval ( QPS5 ) was applied over the primary motor cortex ( M1 ) .
The qualitative changes in physique during the school-age years were examined by showing the changes in the level of body fat accu- mulation with age.
The qualitative data revealed that the program was discontinued due to participants ' low adherence and human resource limitations in the unit's operational dynamics.
The qualitative data were examined by content analysis.
The qualitative evaluation identified important categories of caregivers ' and staff feelings related to the delirium experience.
The qualitative findings also draw attention to the ongoing barriers to healthy aging that can be experienced among older persons with a history of homelessness.
The qualitative observational method of shadowing was used.
THE QUALITY AND QUANTITY OF BONE TISSUE : Developing bones are much more responsive to mechanical loading and physical activity than mature bones.
The quality of care and food provided for clients in long-term care facilities is critical for the prevention of malnutrition.
The quality of care provided for older people is directly related to the attitudes of health care professionals.
The quality of each respiratory signal was assessed by calculating its correlation with a reference oral-nasal pressure respiratory signal using Pearson's correlation coefficient.
The quality of eight studies was moderate , with one study being of lower quality.
The Quality of Life - Alzheimer Disease scale ( QoL-AD ) and Geriatric Depression Scale-15 items ( GDS-15 ) were used.
The quality of life and satisfaction were also studied.
The quality of life and the fall efficacy scores increased significantly at the end of the study.
The quality-of-life construct can be used to assess how well an individual's needs are met or being met by the society.
The quality of life for the participants in groups B and C remained consistent , but that in group A was deteriorated at 24-month follow-up.
The quality of life ( QoL ) in older adults is largely determined by their functional status and health conditions.
The Quality of Life Scale was used to assess quality of life.
The Quality of Life Short Form-36 ( SF-36 ) and the Visual Function Questionnaire ( VFQ-25 ) were also administered.
The quality of mitochondria determines the ability of meiotic divisions , fertilization ability , and activation after fertilization or sustaining development of a new embryo.
The quality of most studies was good.
The quality of relationship-defining memories also predicted marital satisfaction.
The quality of studies was assessed using Jadad and United States Preventive Services Task Force ( USPSTF ) scoring systems.
The quality of the data was manually evaluated , and was found to be of high accuracy ( estimated precision > 86% ) .
The quality of the DCC influenced its use , and the FC's motivation to care for the PWD.
The quality of the evidence on anxiety and social behaviour was very low , so effects were very uncertain.
The quality of the papers was assessed using the Critical Appraisal Skills Programme ( CASP ) assessment tool for qualitative research.
The quality of the studies was evaluated by the mixed-methods appraisal tool ( MMAT ) .
The quality of the supervisor-subordinate relationship and the existence of positive age-related supervisory practices were examined as moderators of this relationship.
The quality scores are studied for their potential as biomarkers to distinguish between the different cognitive groups.
The quality use of medication and its association with health related quality of life ( HRQoL ) have not been reported in Malaysia.
The quantification of these peptides was determined using a stable isotope [ ( @number@ ) N ] -labeled Aβ1-40 internal standard.
The quantification results showed that sjTREC declined in human PBLs in an age-dependent manner ( r = @number@ P < @number@ ) .
The quantified dissection properties were rate dependent for both tissue types ( ILT and wall ) .
The quantitated functional data of EDV , ESV , and EF using the QGSPECT software were assessed in the rest and stress studies.
The quantitative meta-analysis of cross-sectional and longitudinal studies were performed.
The quantitative meta-analysis of cross-sectional studies and that of longitudinal studies were performed , respectively.
The quantitative model of p16-mediated pathway is created in a systematic manner in terms of Petri net technologies.
The quantitative parameters included the mean densities of goblet cells , conjunctival basal epithelium , Langerhans cells , and meibomian glandular acinar units.
The quantitative real-time PCR data confirmed the alterations of the co-upregulated miRNAs.
The quantitative relationships observed should assist in the economic assessment of interventions which effect cognition , function , behaviour and dependence.
The quantitative results from these studies permitted computer simulations that successfully replicated the observed sinoatrial node phenotypes shown by the different experimental groups.
The quantity of high-density regions was positively correlated to stabilogram and statokinesigram variables ( p < .05 or lower ) .
The quantity of immune competent cells in groups with diabetes of various types is different.
The quest for an active and healthy ageing can be considered a \ "wicked problem. \ "
The quest for youth and beauty is an ongoing one.
The question about the existence of this effect in tasks not permitting such compensatory strategies is still open.
The question arises whether it is possible to find a predictive marker to identify a patient population which could benefit from this new treatment option.
The question arises whether training intervention per se is able to reduce the level of this adipokine.
The question for policy makers is whether beneficiaries enrolled in Part D plans exhibit drug utilization patterns comparable with those seen in retiree plans.
The question is how this can be achieved.
The question is how to meaningfully approach this problem.
The questionnaire addressed pain intensity and quality of life variables ( EQ-5D ) .
The questionnaire addressed social background , health-related behaviors , chronic conditions , EQ-5D items , and self-rated health.
The questionnaire also contained items measuring well-being , physical and mental health-related quality of life , and number of chronic conditions.
The questionnaire assessed background characteristics , ( change in ) health / participation problems , and unmet needs.
The questionnaire assesses behavioral responses to music and is answered by the care partner.
The questionnaire covered sociodemographic , behavioral , and health variables , and to verify the aging male's symptoms , the AMS Scale was used.
The questionnaire included questions about participants ' backgrounds.
The questionnaire included socio-demographic characteristics , health variables , and anthropometric measurements.
The questionnaire included socio-demographic characteristics , health variables , and self-reported sleep duration.
The questionnaires for the elderly included their characteristics , economic conditions , ADL , behavioral disturbances associated with dementia , etc.
The questionnaires included a food frequency questionnaire which was used for DII calculation.
The questionnaires included the Physical Activity Scale for the Elderly ( PASE ) and questions about smoking and alcohol consumption.
The questionnaires were conducted in June to @date@ in @number@ different regions ( urban , suburban and rural areas ) .
The questionnaire was completed by the participants before , immediately after , and @number@ months after the intervention.
The questionnaire was distributed by mail and self-completed by participants.
The questionnaire was distributed by post and self-completed by participants.
The questionnaire was provided to patients by a research nurse and was administered in Mandarin.
The questionnaire was validated by exploratory as well as confirmatory factor analysis.
The questionnaire were related to indicators of oxidative stress.
The question of existence of so-called periodontal-systemic connection is discussed.
The question of the present and anticipated future requirement of physicians is central for an appropriate and necessary medical care of the population.
The question of which factors drive human eating and nutrition is a key issue in many branches of science.
The question of why some candidates actually embark on such treatment while others eventually prefer not to freeze remains unclear.
The questions were part of the Short Portable Mental Status Questionnaire , a 10-item free-recall and immediate recall test.
The question therefore arises whether so much complexity can be integrated into microfluidic systems without compromising reliability and throughput of assays.
The quit attempt rates were not different between the intervention and control groups ( @percent@ vs. @percent@ , respectively , p = @number@ ) .
The RAAS deleterious axis increases the production of inflammatory cytokines and raises oxidative stress , exacerbating the insulin resistance and decreasing insulin secretion.
The rabbit models of kidney-yang deficiency were created by pouring Hydroxyurea.
The Radial Atrophy Mapping technique was used to reconstruct the 3D shape of the amygdala and the hippocampus.
The radical resection with complete removal of the tumour remains the main therapeutic approach.
The radicals were detected by fluorimetry , using terephthalic acid as a chemical trap.
The radiographic length of the styloid process was measured on both sides using the measurement toolbars on the accompanying analysis software.
The radiologic outcomes showed no significant difference between groups in terms of volar tilt , radial inclination , or ulnar variance.
The radiopharmaceutical [ ( @number@ ) C ] ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography ( PET ) .
The radius and the shape of the biceps insertion on the radial tuberosity were computerized using a three-dimensional digitizer.
The RalGAPα-RalGAPβ heterodimer shares sequence and structural similarity with Tsc1-Tsc2.
The Ral guanosine triphosphatases ( GTPases ) , RalA and RalB , are members of the Ras superfamily of small GTPases.
The Raman spectra of dried whole human blood excited at @number@ nm are shown to be exclusively due to oxyhemoglobin or related hemoglobin denaturation products.
The rampant diabetes pandemic over the past few decades has been associated with an increased rise in cardiovascular events and deaths.
The RAMs of the subjects were measured from CT images taken at the umbilicus level.
The RAND Corporation / University of California , Los Angeles methodology for a modified Delphi consensus process was used.
The random effect model was used to combine the results.
The range of measurement extends well beyond traditional IADL scales.
The range of motion of metacarpophalangeal joint was normal.
The range of motion preserved depends on the age of the patient.
The range of values was larger in the dorsal forearm than the upper inner arm and was greater in Caucasian subjects than African-American subjects.
The range of variance explained in psychosocial HRQOL was @number@ to @percent@ and the range of explained variance in physical HRQOL was @number@ to @percent@.
The ranges of GLA and GALC were higher in females , whereas GBA was higher in males.
The ranges of motion of thigh , shank , and knee in both swing and stance phase were calculated , in addition to stride duration.
The rank order in average expression in liver tissue and cellular systems was OATP1B1 > OATP1B3 ≈ OATP2B1.
Therapeutic agents targeting the microvasculature and the neurovascular unit may impact both SVD and MS and may benefit patients with dual pathology.
Therapeutic agents that target ECM homeostasis represent promising prevention strategies.
Therapeutic angiogenesis is a relatively new medical strategy in the field of cardiovascular diseases.
Therapeutic approaches include the clearance of senescent cells via the use of senolytics or via the cooperation with the immune system.
Therapeutic approaches that protect synapses from degeneration in the aging brain offer the potential to slow or halt the progression of such conditions.
Therapeutic approaches that target aging processes may be beneficial for halting the progression of disease and improving quality of life in IPF patients.
Therapeutic attempts to cure Alzheimer's disease ( AD ) have failed , and new strategies are desperately needed.
Therapeutic decision-making for patients with multimorbidity ( MM ) is challenging.
Therapeutic drugs including anti-estrogen and aromatase inhibitors are used to treat patients with breast cancer.
Therapeutic effects demonstrated in this preclinical study support further exploration of the possibility to use uMSCs from mismatched donors in lupus nephritis treatment.
Therapeutic gains from AGE restriction constitute a paradigm shift.
Therapeutic goals for HIV-infected patients receiving antiretroviral therapy include minimizing risk of future physical disability.
Therapeutic improvements raise the question of QOL versus cure.
Therapeutic interventions in PCOS women based on lifestyle modification as well as use of insulin sensitizers did not show significant effect on dyslipidemia.
Therapeutic interventions that target old cells could help in the clearance of chronic infections.
Therapeutic management of gait and balance impairment during aging and neurodegeneration has long been a neglected topic.
Therapeutic manipulations to preserve and enhance healthier fat in order to correct obesity-related metabolic disorders seem to be a relevant but still unexplored opportunity.
Therapeutic mechanisms of MSCs in the treatment of ARDS / COPD were focused on cell engraftment and paracrine action.
Therapeutic modalities imply photoprotection with sunscreens that prevent sunburns and block ultraviolet irradiation.
Therapeutic opportunities for TBI remain very limited with patients subjected to surgery or rehabilitation therapy.
Therapeutic properties of tea Camellia sinensis are of particular interest since it has been consumed for ages and was always regarded as safe beverage.
Therapeutic self-care is the ability to take medications as prescribed and to recognize and manage symptoms that may be experienced , such as pain.
Therapeutic sialylation of ANGPTL4 could limit albuminuria.
Therapeutic strategies should focus on supporting normal angiogenesis.
Therapeutic strategies that bridge the nutrient sensing pathways and circadian clock might be rational designs to defy aging.
Therapeutic success is less common in older patients ( > @number@ years ) than it is in younger patients with AML.
Therapeutic synergy between foods and drugs does not necessarily mean that both have the same primary target.
The rapid aging of the population and a higher prevalence of diabetes will probably translate into a burden of ESRD in the future.
The rapid aging of the world's population is causing an increase in the prevalence of cognitive decline and degenerative brain disease in the elderly.
The Rapid Assessment of Physical Activity was used to assess aerobic and anaerobic activity levels.
The rapid growth of the testosterone market in the past @number@ years is due to many factors.
The rapid increase in the ageing population of most developed countries is presenting significant challenges to policymakers of public healthcare.
The rapidly aging population and their frequent use of hospital services will create substantial quality challenges in the near future.
The rapidly growing elderly population has specific physiological characteristics , which makes it susceptible to colonization and subsequent infection due to Candida species.
The rapidly increasing prevalence and serious consequences of sarcopenic obesity are recognized as a critical public health risk in the aging society.
The rapid progression of the disease was observed in @number@ patients , slow progression in @number@ patients.
The rapid technological advancements achieved in the last years have boosted the progressive identification of age-associated epigenetic changes.
The rapid ubiquitination results in accelerated accumulation of 53BP1 and RAP80 at DSBs , which in turn protects DSB ends from resection in OTUB2-depleted cells.
Therapies designed to improve arterial resistance and particularly to enhance aortic compliance may hold promise to prevent or reverse cardiac ageing and its sequelae.
Therapies for back pain can be nonpharmacological , pharmacological or surgical.
Therapies , outcomes and mortality are often influenced by age and elderly must have a specific and a multidisciplinary approach.
Therapies restoring the stress response can re-tip the balance from disease into health and address the multifaceted defects associated with the disease.
Therapies that block B7x and B7-H3 , either as monotherapies or in synergism with traditional therapies , should be pursued.
Therapies that increase megalin expression at the choroid plexus could potentially control accumulation of brain Aβ.
Therapies that restore regenerative capacity may therefore be beneficial.
Therapies to extend healthspan are poised to move from laboratory animal models to human clinical trials.
Therapist focus groups were conducted and stroke outcomes were used to assess patient response.
Therapist response was determined from the focus groups ; patient response was measured by standardized assessments.
Therapist's adherence had no relationship to outcome , but the higher application of modifying dysfunctional thoughts was associated with higher goal attainment.
Therapist's adherence to the manual was also assessed.
Therapy can be maintained or changed dependent on the achieved intraocular pressure ( IOP ) and side-effects.
Therapy included different vasotropic remedies , as well as family therapy , art therapy , and cognitive training.
Therapy-induced bone loss such as bisphosphonate-associated osteonecrosis of the jaw also increases in incidence with age.
Therapy of glabellar lines , which has received regulatory approval , is presented in detail.
THERAPY : Patients with active or symptomatic disease or with advanced Binet or Rai stages require therapy.
Therapy should be chosen based on the type of osteoporosis.
Therapy should start with a thiazide diuretic ( best evidence ) or an angiotensin-converting enzyme inhibitor.
Therapy to prevent or limit LV remodeling is of paramount importance , and it should be started in the early phase of reperfusion.
Therapy with BTX also ranks high in curative dermatology.
Therapy with doxycycline hydrochloride and minocycline hydrochloride led to partial improvement in one case and resolution in another.
The Rasch measurement model was used to form an interval-level score and fit to this model was assessed.
The Ras-Raf-MEK-ERK pathway plays a central role in tumorigenesis and is a target for anticancer therapy.
The rat clinical FI has significant value for use in aging and interventional studies.
The rate and pattern of calcification had no relationship to age.
The rate constant of elimination of both drugs was greatly decreased and the elimination half-life was significantly greater in old compared with young rats.
The rate-limiting step in the production of Aβ from APP is mediated by the β-site APP-cleaving enzyme @number@ ( BACE1 ) .
The rate of 1-month CPC 1-2 was @percent@ ( @number@ , 650 / 35 , 709 ) .
The rate of adverse events was low.
The rate of age-related shortening of telomeres is highest early in life and decreases with age.
The rate of aging-related increase in fat contents is gender-dependent.
The rate of a one-week ER revisit was @percent@ and the 30-day rehospitalization rate was @percent@.
The rate of beer aging is affected by storage conditions including largely time and temperature.
The rate of bone loss varies across the aging period via multiple complex mechanisms.
The rate of change varied according to functional and anatomical regions of the brain.
The rate of coinfection with these TBDs in humans is unclear as most studies have focused their prevalence in ticks or rodent reservoirs.
The rate of completed 30-day outpatient follow-up also improved.
The rate of complete resection was @number@ % , incomplete @number@ % , not estimable @number@ %.
The rate of correct response in naming colour ( accuracy ) and associated reaction time ( RT ) were recorded for the cognitive task.
The rate of decline for both DB and SB was approximately @percent@ per year.
The rate of decline was higher among the late-onset phenotype than in the adult phenotype.
The rate of decline was two to four times greater in the terminal phase relative to the preterminal phase , depending on the domain.
The rate of development and marketing of these devices has increased exponentially within the last decade.
The rate of donors over @number@ years of age has increased from @percent@ in the period of 1983-1995 to @percent@ in the last @number@ years.
The rate of extensive ( ileocecal + hemicolonic ) resection in all operated patients was @percent@.
The rate of glycation was evaluated using several analytical methods.
The rate of growth was more profound in youth , but also occurred in early adulthood.
The rate of hemorrhagic stroke remained stable at @percent@ and did not differ by subgroups.
The rate of human schistosomiasis increased in Al- Baha Province , Saudi Arabia in the last few years.
The rate of increased PP remains stable between @number@ and @percent@ , irrespective of sex , age , and the control population.
The rate of increase in aortic stiffness with normal aging has been previously described.
The rate of increase of longevity has varied considerably across U.S. states since @number@
The rate of inflammation increases in elderly individuals , a phenomenon called inflammaging , and is associated with degenerative diseases.
The rate of local ( voxel-wise ) volume change per year was compared between groups and its relationship with clinical outcomes was assessed.
The rate of malnutrition in the individuals living alone was found to be higher than that of those living with their families.
The rate of meningitis decreased with increasing age , as did admission to intensive care and use of mechanical ventilation.
The rate of muscle loss with aging is higher in men than women.
The rate of nodule formation was @percent@ at a minimum follow-up of two years.
The rate of older adult falls has increased dramatically in North Carolina.
The rate of ordering was most disparate for biopsies of cancerous and benign lesions.
The rate of polymerization was reduced in antioxidant-doped adhesives.
The rate of recurrent venous thromboembolism was lower but the rate of major bleeding was higher with edoxaban than with dalteparin.
The rate of senescence can be inferred from the acceleration by which mortality rates increase over age.
The rate of shunt revision per patient-year initially decreased as age increased , except for an increase in revision frequency in the early teen years.
The rate of skin aging , or that of tissue in general , is determined by a variable predominance of tissue degeneration over tissue regeneration.
The rate of TEAEs did not increase over @number@ months of repeated treatment ( mean @number@ cycles ; range 1-9 ) .
The rate of telomere change was distinct for T-cells , B-cells and monocytes for any given subject.
The rate of telomere shortening can be either increased or decreased by specific lifestyle factors.
The rate of telomere-shortening has been widely reported as a marker of risk for age-related conditions and mortality in human population.
The rate of torque development increased only in the water-based group around the hip extensors muscles ( P < @number@ ) .
The rate of tube replacement of home healthcare patients in Taiwan deserves to be paid more attention.
The rate / quality of human aging and the development / progression of diseases depend on a complex interplay among genetics , epigenetics and environment.
The rates in urban regions were higher than in rural regions.
The rates of adverse events were similar among these groups ; the most common events were diarrhea and nausea.
The rates of both cardiac death and all-cause death were significantly lower in the PCI group.
The rates of changes in MF and MPF were calculated.
The rates of child and adult obesity have increased in most developed countries over the past several decades.
The rates of increasing vs. decreasing abdominal pain score were @percent@ ( @number@ @number@ ) vs. @percent@ ( @number@ @number@ ) respectively.
The rates of medical conditions will be compared to a non-psychiatric peer group.
The rates were adjusted by a direct method using the WHO-2000 standard population.
The ratings and factors underlying avoidability differ between hospital and SNF staff.
The ratings of fatigue were related to glazed eyes and to all the cues affected by sleep deprivation ( P < @number@ ) .
The ratio is about @number@ patients per carer in the SH units and is also stable.
The rationale lies on epidemiological observations that have noted a tenfold higher incidence of SUDEP in adults.
The rationale of the study was to examine how these respondents explain loneliness among the elderly.
The ratio of Aβ42 to Aβ40 rather than absolute levels of the peptides can aid in the identification of incipient AD among MCI patients.
The ratio of IGF1 / IGFBP3 was not associated with metabolic syndrome.
The ratio of LV mass to LV volume was also calculated.
The ratio of muscle thickness to height was calculated.
The ratio of [ NAD ( + ) ] / [ NADH ] was very low in the whole body and mitochondria of control LB25.
The ratio of observed-to-estimated mortality rates ( OE ratio ) was used as a metric of surgical quality.
The ratio of peak VO2 and SMI was significantly higher in the statin treatment group.
The ratio of posterior scleral thickness to scleral thickness in the pars plana region decreased significantly with increasing axial length.
The ratio of severe cases in @number@ was higher than in @number@ ( @number@ vs @percent@ , P < @number@ ) .
The ratio of thickness of the large choroidal vessel layer to total choroidal thickness was calculated.
The ratio of trauma case in the @number@ was higher than that in @number@ ( @number@ vs @percent@ , P < @number@ ) .
The ratio of YPLL for CVD in all death causes showed increase trend ( chi2 = @number@ P < @number@ ) .
The ratio Q10 / cholesterol and Q10 / LDL increased in these people.
The ratios Ang1 / Tie-2 and VEGF / KDR and Akt levels were also determined.
The rats in the normal control group and aging model group were not received any treatment.
The RAVLT learning and delayed recall scores also correlated with the hippocampal part of the cingulum bilaterally.
The raw data files for the samples were assembled into a single project for joint calling.
The raw data were automatically segmented into @number@ layers using the 3D graph search approach.
The RBC acetylcholinesterase level was elevated in the experimental group but was not in the control group.
The R code is published in one of the Additional files and is available at @url@ .
The rd8 mutation is found in C57BL / 6N but not in C57BL / 6J mouse sub-strains.
The Reach , Effectiveness , Adoption , Implementation and Maintenance ( RE-AIM ) framework was followed to assess the program.
The reach of the intervention was @percent@.
The reactive oxygen species that are generated by aerobic metabolism and environmental stressors can chemically modify proteins and alter their biological functions.
The readability of @number@ % of the PILs had a score above @number@ which is considered difficult for older people to understand.
The reader is presumed to have a basic understanding of facial anatomy and facial rejuvenation procedures.
The readers measure the movement of objects such as medicines , foods , drinks , dishes , utensils.
The reading span task was used to measure working memory components by examining processing accuracy , processing time , and end-word recall of sentences presented.
Thereafter , an association between PML and monoclonal antibody therapy has come into light.
Thereafter , the brain was processed with a special method ideally suited for cytoarchitectonic analyses.
Thereafter the decline is less steep except for changes in future plans and feeling needed.
Thereafter the epidermis thinning was observed , together with the progressive decrease of keratinocyte proliferative activity and an increase of the fraction of p53-positive cells.
Thereafter , the @number@ older trained and untrained participants took part in a @number@.5-h post-test phase again with both devices.
Thereafter , the phase shifting effects of ACh prompted researches to view ACh as an agent for nocturnal clock resetting.
Thereafter the rate of bone substance loss slows to the same rate as seen in aging men and is likely related to aging itself.
Thereafter , the subjects were taken to the gym to perform their exercise sessions or remained at rest during the same time period.
Thereafter they function automatically as a result of a supraspinal network that controls spinal pattern generators.
Thereafter , they performed 14-minute rhythmic PWM at @number@ Hz and this was followed by @number@ minutes of QS.
Thereafter , trained interviewers collected psychometric data by interviewing the patients at home.
Thereafter , various drugs targeting VEGF-mediated signals have been developed to control tumor angiogenesis.
The real age plus the optimal deviation is taken as the brain pathological age.
The real costs in @number@ were by far closer to those in the conventional scenario than to the reductions expected in the objective scenario.
The realignment to PHC was positively correlated with free recall but not non-memory measures , implying a reconfiguration that is beneficial to residual memory.
There also exists a range of functioning on executive tasks during normal aging.
There also were no changes in body fat percentage , muscle strength , and muscle fiber type characteristics.
The real statistical analysis was planned by covariance structure analysis.
There , an effect of PrP ( C ) on tau expression could be observed under oxidative stress conditions but not during aging.
There appears to be a bi-directional relation between sleep disordered breathing ( SDB ) and cerebrovascular accidents.
There appears to be a common mechanism through which estrogens can protect against CVD and AD.
There appears to be a need for a standardised test protocol for colour stability of maxillofacial materials.
There appears to be a strong relationship between TD and metabolic syndrome , though the relationship is not certain to be causal.
There appear to be considerable differences between guidelines in terms of the guidance given to clinicians.
There are about @number@ different HDL-associated proteins ; however , there are many more lipid species potentially associated with HDL particles.
There are a few main findings to report.
There are also a few empirical findings that cast doubt on that conclusion.
There are also changes in the tone and character of facial muscles.
There are also factors present at particular life stages , such as childhood or adolescence , which predict back pain in adulthood.
There are also major differences in how the sexes respond to stroke at the cellular level.
There are also medical conditions that occur more commonly with advancing age.
There are also new options defining CLM associated with respiratory events.
There are also new unknowns and skin issues which arise from large numbers of people in the 9th and 10th decades.
There are also potential uses in the areas of anti-aging , skin-whitening , and pigmentation reduction products.
There are also thousands of diseases , dozens of which latently occur in the body of each person.
There are an estimated @number@ million people with dementia across the world , of whom @percent@ experience regular pain.
There are an estimated @number@ new cases of VI per year in people aged ≥50 years per @number@ people , of whom @number@ are blind.
There are an estimated ten times more bacteria in an individual than human cells.
There are an increasing number of reports of permanent CIA.
There are an increasing number of studies on the localization of personality using voxel-based morphometry.
There are a number of controversies surrounding resveratrol that have not been resolved.
There are a number of limitations to the research and there are still significant gaps in knowledge in this field.
There are a number of mechanisms suggested to explain age-related endothelial dysfunction.
There are a number of previously untested domains of personal competence which could influence social vulnerability in later life.
There are a number of profile candidates.
There are approximately @number@ chemicals that can function as ultraviolet ( UV ) filters.
There are approximately @number@ hospitals in the United States , @number@ , 000-4 , 000 that are antiquated or obsolescing.
There are a variety of different mechanisms of DDD ( genetic , mechanical , exposure ) .
There are a variety of factors related to aging itself that affect the presentation of asthma in the elderly and influence diagnosis and management.
There are certain lipid modifications associated with the somatopause , characterized mainly by an increase in total cholesterol and triglyceride levels in both genders.
There are concerns that an aging population over the next decade and changing lifestyle patterns may translate into a higher CRC incidence.
There are conflicting data regarding the effects of exercise on androgen status.
There are conflicting reports about the stage during disease progression at which nigral iron change occurs in PD.
There are controlled trials and a growing body of open-label reports on their use in clinical care.
There are currently > 5 million people in the United States who have been diagnosed with Alzheimer's disease.
There are currently multiple forms of ablative therapy to correct such concerns.
There are currently no curative therapies available.
There are currently no cures , but there are promising potential therapies that target the underlying disease mechanisms of dry ARMD.
There are currently no treatments to effectively prevent or treat dementia.
There are currently @number@ member studies , from regions that include Asia , Australia , Europe , and North America.
There are differences between racial minority groups on help-seeking and acceptability of services.
There are differences in health behaviours and health conditions between genders and by ethnicity in advanced age.
There are different clinical conditions that can mediate abnormal platelet activation and favors pathological thrombosis and CVD.
There are different subtypes of Mild Cognitive Impairment taking in consideration the cognitive domains that are affected , being the amnestic subtype the most common.
There are discrepancies with respect to the age at which adult-like performance is reached on tasks assessing global motion perception.
There are doubts as to whether performance in this task remains unchanged with the aging process.
There are emerging initiatives that address the transgender and gender non-conforming population.
There are emerging results indicating that AMPK signaling can inhibit the inflammatory responses induced by the nuclear factor-κB ( NF-κB ) system.
There are endogenous anti-oxidant defense systems that have the potential to partially counteract ROS impact.
There are evidences that stem cells also exist in adult gonad , and can maintain the renewal of germ cells and decelerate aging process.
There are evidences that the risk of developing dementia may be reduced by modifiable risk factors.
There are few cross-country comparisons of socioeconomic differences in healthy life expectancy.
There are few data available on the effect of the macronutrient composition of clinical supplements on the postprandial muscle protein synthetic response in older subjects.
There are few defined risk factors for the modest elevations in inflammatory markers seen with aging.
There are few epidemiologic studies on vitamin D status of postmenopausal women in Iran.
There are few long-term nationally representative studies of all-cause mortality among those infected with hepatitis C virus ( HCV ) .
There are few precedents for using dyadic interviews as a technique for qualitative research.
There are few prospective studies that evaluated the role of CGA in treatment choice.
There are few studies about how patients with dementia recognize familiar music.
There are few studies directly comparing the comprehensive neuropathology of amnestic ( aMCI ) and nonamnestic ( naMCI ) MCI.
There are few studies from East and Central European countries on health-status , lifestyle and social circumstances of medical professionals.
There are few studies on Baastrup´s disease epidemiology and their results are inconsistent.
There are gaps in the literature regarding the utility of providing home care to CKD patients and the impact this has on healthcare resources.
There are gendered differences in perceptions about aging and appraisals of sleep.
There are , however , caveats to this assessment.
There are , however , many factors that interfere with the way the immune response functions.
There are , however , several degrees of neuroinflammatory responses , some of which are positive.
There are important , yet poorly studied , sex differences in cardiometabolic disease.
There are increasing data indicating profound ethnic differences in the levels of virilization of males.
There are increasing needs for QOL-emphasizing home-based care for patients in the intermediate stage after completion of acute stage treatment , or for end-of-life care.
There are increasing reports of azole-resistant Aspergillus spp.
There are issues that are particular to the Asia-Pacific region involving diet and prevalence of specific respiratory diseases.
There are large variations in the type of DCE-MRI sequence , the imaging protocols and the contrast agents used.
There are limited data on intra-individual telomere length ( TL ) variability in DC and related disorders.
There are limited data regarding age and sex differences in the TSH-T₄ relationship.
There are limited data regarding the effect of age on the risk of ventricular tachyarrhythmias ( VTAs ) .
There are many age-associated changes in the respiratory and pulmonary immune system.
There are many agents that inhibit IGF1R in oncology clinical development , and in some cases , they have been associated with rapid tumor regression.
There are many aspects that have to be assessed before treating an elderly patient , or before to choose the treatment itself.
There are many causes of anaemia ; anaemia balance is a complex diagnostic process.
There are many challenges for establishing recommendations for intakes of nonessential food components.
There are many devices that are now available.
There are many different medical history patterns between individuals with dementia and normal controls.
There are many different ways to protect skin against UV radiation's harmful effects.
There are many molecular mechanisms involved and exogenous factors such as stress also contribute to the aging process.
There are many more to write about the elderly.
There are many observational studies exploring the potential association between adherence to the Mediterranean diet and cognitive decline.
There are many options in the treatment of changes caused by chronic actinic damage.
There are many proposed mechanisms of age-related muscle loss that include the endocrine system.
There are many somatic and potentially psychologic benefits of fasting or intermittent calorie restriction.
There are many studies about bone aging from the aspects of osteoporosis and other bone diseases.
There are many studies showing a clear role for endogenously produced melatonin and clear effects of melatonin supplementation.
There are many studies showing the effects of colours on brain activity.
There are many techniques , which we will present.
There are many variables determining the complex situation that are interconnected.
There are many ways to study aging in vitro.
There are marked differences between RCFs which make them difficult to compare.
There are mixed findings regarding racial and ethnic differences in the use of CAM.
There are multiple age-related deficits in both the innate and adaptive systems that may play a role in the increased incidence of cancer.
There are multiple factors contributing to facial aging.
There are multiple factors , which may apply pathophysiologically , including the residual immune dysregulation syndrome and antiretrovirals alone.
There are multiple genetic links between schizophrenia and a deficit of proline dehydrogenase ( PRODH ) enzyme activity.
There are multiple mechanisms by which cells evade TGF-β-mediated growth inhibitory effects.
There are multiple peptides available that will achieve different topical results.
There are no age-correlated changes of dermal eosinophils quantity observed.
There are no approved therapies for muscle wasting in children infected with human immunodeficiency virus ( HIV ) , which portends poor disease outcomes.
There are no comparative studies of adherence to medicines in the older-aged living in indigenous communities compared to other communities.
There are no competing interests.
There are no currently Food and Drug Administration-approved or proven off-label treatments for the frontotemporal dementias ( FTD ) .
There are no current published tools available to predict functional decline following cardiac surgery.
There are no data on ES after syngeneic HSCT.
There are no data regarding geriatric dermatologic diseases are available from Nepal.
There are no data to determine the safety or efficacy of HAART initiation in the ICU.
There are no default formulas for selecting priority issues.
There are no disease-altering therapies for dry AMD , which is characterized by accumulation of subretinal drusen deposits and complement-driven inflammation.
There are no effective TDP-43-directed therapies for ALS or related TDP-43 proteinopathies , such as frontotemporal dementia.
There are no effective treatments.
There are no epidemiologic estimates of prevalence for many visually-impairing conditions.
There are no financial conflicts of interest to report.
There are no follow-up data available either on post-freezing changes in relational status , or on attitude towards the undergone treatment and the reproductive outcome.
There are no longer doubts about the existence of gender's differences in cognition , only their origin is still controversial.
There are no pharmacologic agents for the treatment of sarcopenia.
There are no previous studies exploring HRQoL among stroke survivors in Ghana , despite the increasing public health significance of the disease in this country.
\ "There are no problems with cardiotoxicity with croton oil-phenol peels if done appropriately. \ "
There are no randomized controlled trials investigating long-term outcomes of testosterone replacement therapy in populations with or without ESRD.
There are no recent published reviews that compile the efficacy and safety evidence for recommended immunizations in older people.
There are no reported studies from the developing world including Africa.
There are no reports about the serum HE4 reference intervals ( RIs ) with electrochemiluminescence immunoassay ( ECLIA ) .
There are normal changes to sleep architecture throughout the lifespan.
There are no Scottish data on the resources and costs of treatment of the scalp psoriasis patient.
There are no significant differences between the hemodynamic and nutritional conditions in both groups.
There are no studies of sleep disorders and subjective ratings of skin appearance or cutaneous body image ( CBI ) .
There are no studies of whether APOE-e4 moderates the relationship between exercise and later life depressive symptoms.
There are not enough studies , especially demographic ones , evaluating lower urinary tract symptoms and / or nocturia in males and females.
There are no treatments for white fibrous papulosis of the neck.
There are not yet sufficient data to recommend oocyte cryopreservation for the sole purpose of circumventing reproductive aging in healthy women.
There are no unified and universally accepted evidence-based practice guidelines on the management of heartfailure in this population.
There are no unique diagnostic methods or treatment modalities in the care of the geriatric patient with AKI.
There are no validated techniques for an early detection of pulmonary cancer lesions other than low-dose helical computed tomography scan.
There are now precise tools to investigate PTMs and visualize cellular structures that have been underexploited in the study of desminopathies.
There are @number@ levels of integrative systems : homeostatic ( organismal ) , systemic and cellular-molecular.
There are @number@ main forms ( vitamin K1 and vitamin K2 ) , and they come from different sources and have different biological activities.
There are @number@ male cases and @number@ female cases individually matched with their nondiabetic controls on age.
There are @number@ people living with Parkinson's in the UK.
There are @number@ phases of the HealtheSteps™ program , lasting @number@ months each.
There are numerous barriers to glaucoma treatment adherence in the literature , including cost.
There are numerous examples of hormetic effects ranging from mild stresses of irradiation to heat stress , hypergravity , pro-oxidants , or food restriction.
There are numerous examples of sex differences in brain and behavior and in susceptibility to a broad range of brain diseases.
There are numerous laser and light technology instruments for cosmetic improvement of skin appearance.
There are occasions however , in which memory occurs more spontaneously ( e.g. , an acquaintance seeming familiar out of context ) .
There are only a few long-term studies on how knee or hip OA affects the course of physical performance.
There are only few case reports of psychoses in patients with Sheehan's syndrome.
There are only few data on sarcopenia in healthy general population.
There are only minimal data on the association between alcohol and brain magnetic resonance imaging ( MRI ) markers.
There are @percent@ cases with positive family history of prostate cancer Worldwide.
There are physician-related and population-related barriers which impede palliative care development.
There are physiologic changes associated with aging.
There are recent reports of hybrid tissue-fabric materials with good performance-high biocompatibility and high mechanical strength.
There are relatively few migrant mortality studies in Germany , which is primarily due to the restricted quantity and quality of existing data.
There are relatively few studies investigating toxic effects of Aβ on the endothelial cells of the blood-brain barrier ( BBB ) .
There are seven mammalian sirtuins , SIRT1-SIRT7 , which are localized to different cellular compartments and are capable of diverse catalytic activities.
There are several age-related diseases with no appropriate treatment ; therefore , the complex aging phenomena needs further understanding.
There are several algorithms and strategies for assessing frailty syndrome , but currently , no universally accepted definition or measurement protocol has been determined.
There are several approaches and methods that can be used to identify dementia cases.
There are several characteristic features such as tumor location , histology , biological behavior and pathway of carcinogenesis in malignant neoplasms occurring in the elderly.
There are several chemicals and mixtures that impair male fertility.
There are several comprehensive reviews on all these topics.
There are several factors possibly and / or certainly influencing dementia risk including non-modifiable and modifiable risk factors.
There are several groups across Italy working actively on basic science of aging producing high impact papers with a significant contribution to biogerontology.
There are several intricate causes.
There are several key areas in which treatment could be improved to reduce the incidence and severity of HAND.
There are several methods for estimating telomere length ( TL ) from extracted DNA samples.
There are several pathways for generating ATP in skeletal muscle that allow adequate ATP supply to meet increased demand during muscle activity.
There are several possible explanations for this decline at the tissue , cell , and molecular levels , which are described here in.
There are several possible reasons for these discrepant data.
There are several presumed causes of this condition and anthropologists consider skull porosities as a marker of physical and nutritional stress.
There are several reasons for a lack of significance for the other candidates including platform differences and the use of serum rather than plasma samples.
There are several studies investigating the impact of the various forms of MT on alleviating BPSD.
There are several suggestions that such visuomotor learning requires lowering the gain of the proprioceptive inputs.
There are several therapies currently available in Japan for the treatment of postmenopausal osteoporosis , each with a unique risk / benefit profile.
There are several ways in which an evolutionary perspective can enrich medical education and improve medical practice.
There are several ways in which we might select potential pharmacological interventions for testing in clinical trials.
There are several ways to evaluate inappropriate prescribing , with various levels of support for their use.
There are significant age and sex differences in LV volumes , EF , and geometry , whereas mass differs between sexes but not age groups.
There are significant differences in sleep characteristics and chronotype between people with SADW and no-SAD.
There are significant differences in the classification of financial status , according to the groups ( p = @number@ ) .
There are significant differences in the mechanical properties of the two human mitral valve leaflets from this advanced age group.
There are significant inter-individual differences in the levels of gene expression.
There are situations in which the parameters of the model are subject to some restrictions or constraints.
There are some data relating to opioid use for noncancer pain in older people.
There are some early data postulating that cancer itself may impair ovarian reserve.
There are some little studies that show lamotrigine efficacy in bipolar depression in elderly.
There are specific multimorbidity patterns and individual associations between physical and mental conditions , which bring new insights into the complexity of chronic patients.
There are specific pattern of frequency of dermatoses in elderly.
There are three time-related factors affecting cancer mortality , of which the cohort effect is one.
There are thus plenty of possibilities for adaptive changes in the spinal motor circuitries both early and late in life.
There are two domains ( mental health and performance ) that are positively evaluated by more than two-thirds of senior citizens.
There are two hallmarks of aging that must be considered primary concerns when trying to improve health for older adults : frailty and chronic diseases.
There are two main types of nanodelivery systems , liquid and solid.
There are two major approaches in the current management of photoaging.
There are two members of the vasohibin ( VASH ) family , VASH1 and VASH2.
There are two possible explanations for this failure.
There are two variations in GJA3 ( c.-39C > G , c.
There are two viewpoints concerning cardiac regeneration.
There are two ways to picture white matter : as a grid of electrical wires or a network of roads.
There are two well-known but opposing concepts of the reason for aging.
There are various definitions of biomarkers and also different classifications of the same.
There are very preliminary data on AMH as a predictor of menopause.
There are well-established associations between diabetes and fracture risk and yet the mechanism underlying these associations are controversial.
The reason brain hypometabolism develops is unclear but may include defects in brain glucose transport , disrupted glycolysis , and / or impaired mitochondrial function.
The reason for consultation was basically facial ageing ( @percent@ ) and loss of facial volume ( @percent@ ) .
The reason for the high vulnerability of entorhinal cortex neurons to neurofibrillary tangle pathology and Casp6 activity is unknown.
The reason for the robust placebo response in the IM group is not clear , but has been occasionally reported.
The reason for this causal association remains poorly understood.
The reason for this difference is considered to depend on methodological factors.
The reason for this difference remains to be determined.
The reason for this enhanced reactivity was investigated using peptides.
The reason for this hype lies in the potential of stem cells to drastically increase quality of life through repairing aging and diseased organs.
The reason for this is not yet understood.
The reasoning can be widened to a more general setting including an extension of the Gyllenberg-Webb model with a nonlinear birth rate.
The reason of early return of the reflected pressure wave in infancy is their height.
The reason patients who were listed did not receive a transplant was usually death on the waiting list.
The reasons are still unclear.
The reasons behind these trends are unclear , but could include increasing incidence , detection rates , severity of disease or age of the population.
The reasons for admission to ED as well the diagnosis at the time of hospital discharge were separated into social and health disorders.
The reasons for failure of the surgery were analysed in detail based on history , physical examination , imaging studies and surgery reports.
The reasons for these differences remain unclear.
The reasons for the survival differences between both countries require clarification.
The reasons for this are complex and poorly understood.
The reasons for this are uncertain.
The reasons for this are unclear and have sometimes been attributed to socio-economic differences.
The reasons for this failure include the emergence of insecticide resistance and the narrowing of the spectrum of efficient products.
The reasons for this translational gap are discussed.
The reason was a faster increase in base of support.
The rebalancing of stroke care and research initiatives requires a reinvestment in rehabilitation and community reintegration of stroke survivors.
The rebuild-up was observed more frequently in younger age groups ( less than @number@ years ) and Suzuki stages III.
Thereby , incipient functional decline is recognized , e.g. in GPs ' practices and senior community health centers , to initiate early appropriate preventive action.
Thereby , noise-induced hearing loss is an important factor that worsens over time in addition to age-related hearing loss.
Thereby , people retrospectively described the sources as having made more statements that fit with stereotypes about their age group than they had truly made.
Thereby , we identified @number@ proteins , including @number@ proteins with an age-associated abundance change.
The receiver operating characteristic curve showed a cutoff score of @number@ with sensitivity and specificity of @percent@ and @percent@ , respectively.
The receiver operating characteristics curve analysis showed that γ-tocopherol may serve as a good predictor for GBS.
The recent aging trend in the United States has resulted in exponential growth in the number of informal dementia caregivers.
The recent commercialization of specific detection methods has offered new opportunities to go further in the understanding of glicentin physiology.
The recent development of an FI in naturally ageing mice provides an opportunity to conduct frailty research in a validated preclinical model.
The recent development of animal models of frailty , and tools for assessing frailty in animal models provides an invaluable opportunity for frailty research.
The recent emergence of faecal microbiota transplantation has played an important role in treating recurrent Clostridium associated diarrhoea.
The recent emergence of GSK-3β as a regulator of myocardial fibrosis will also be discussed.
The recent evidences indicate that autophagy is associated with a number of pathological processes including cancer , muscular disorder and neurodegeneration in addition to longevity.
The recent literature has suggested that nutrition could differently influence the health of male and female individuals.
The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission.
The recent recession constitutes one of the macro forces that may have influenced workers ' retirement plans.
The recent revival of old theories and setting them on modern scientific rails to a large extent are also relevant to mitochondrial science.
The recent spermidine / mitophagy theory is gaining momentum.
The recent years have seen the emergence of graph theoretical analysis of complex , functional brain networks estimated from neurophysiological measurements.
The receptor for advanced glycation end products ( RAGE ) regulates cellular proliferation in hepatocellular carcinoma ( HCC ) .
The receptor for AGEs ( RAGEs ) has been implicated in the lung fibrotic process and the alveolar homeostasis.
The receptor of advanced glycation endproducts ( RAGE ) , is a multi-ligand receptor belonging to the immunoglobulin superfamily.
The receptors for melatonin , the membrane bound melatonin receptors @number@ and @number@ are present on some smooth muscles , neurons , and epithelium.
The recession temporarily eased the health care workforce shortage , but our aging population will boost both retirements and demand for your services.
The recipients used an oral / vaginal graduated estradiol regimen followed by intramuscular and vaginal progesterone.
The reckoning process was also moderated by assumptions about loci of control and self-efficacy and the information available to participants.
The recoding and rehearsal processes are mediated by articulatory control process in the left ventrolateral prefrontal cortex ( VLPFC ) .
The recommendation for guiding treatment based on MICs is supported only marginally.
The recommendations included appropriate medical and surgical perioperative care , which requires , especially in the elderly , a multidisciplinary approach including orthogeriatric care.
The recommendations provide direction for health policy , education , and clinical practice.
The recommendations should not be rigidly applied and implementation will differ from country to country.
The recommended current treatment modality depends on the Gleason grade , stage , PSA levels , and associated comorbid conditions.
The recommended daily vitamin D and K requirements are 400-800 IU and 250-300μg , respectively.
The recommended final concentration of BTA was @number@ U / mL after reconstitution with physiologic saline.
The recommended schedule is : @number@ mg / day for @number@ days , with @number@ days drug free.
The reconstructed digital web-spaces had good appearance and soft texture.
There continues to be a strong correlation between BMI and %BF in adult women as they age.
The recorded average temperatures , on a monthly basis , were inputs of the predictive model.
The recording spanned a mean duration of @number@ hours , including sleep.
The recoveries of Pls from human plasma were nearly @percent@ , and matrix effects were not observed.
The recovery function of cortically generated auditory evoked potentials has not been investigated in cochlear implant ( CI ) users.
The recovery of amino acids from a porous surface can be used as a measure for the efficacy of a visualization agent.
The recovery of MVC was correlated with the CAR in older adults ( p = 0.001 ) .
The recovery of serum sulfatide might derive from the attenuation of systemic oxidative stress.
The recovery rate of MVC was greater ( p < 0.001 ) in the young adults vs the older adults , with no sex effect.
The recovery rate of the second fingertip and dorsum after cold stimuli was lower than @percent@ in @percent@ and @percent@ patients , respectively.
The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability.
The recruitment goal is @number@ patients ( @number@ per arm ) .
The recruitment of patients will be completed during @number@
The recruitment of prospective memory target monitoring seems to be influenced by perceived task importance.
The recruitment paradigm targeted known barriers and identified those unique to the study's urban environment.
The recurrence of pneumothorax after surgery was @number@ cases.
The redacted Canadian data set suggests resident-to-resident abuse makes up approximately one-third of reported abuse cases.
The redox potential was then compared with functional biological activity , and the para-hydroquinones demonstrated a superior neuroprotective profile.
The redox reactions involving oxidants and antioxidants play a key role in many biochemical pathways and cellular biosynthesis and regulation processes at the molecular level.
The reduced bone mass tends to be distributed farther from the centroidal axis ( increase in radius of gyration with decline in CSA ) .
The reduced expression of SIRT6 via treatment with SIRT6 siRNA dramatically enhanced the OGD-induced release of HMGB1 in SH-SY5Y cells.
The reduced offset found in older adults may reflect an age-related decline in endogenous inhibitory systems.
The reduced repolarization reserve was reproduced decreasing the IKs current.
The reduced serum levels of Klotho and sclerostin were also correlated with concentric LV remodeling.
The reduced stiffness of cells from the older donor group corresponds to the measured decrease of actin in these cells.
The reduction in A1C was similar for the @number@ groups.
The reduction in frailty was greater for the group that used a walking aid.
The reduction in phosphate levels was inversely associated with bioavailable testosterone.
The reduction in the amount of care for elderly individuals living with a cohabitant was substantially greater for males than for females.
The reduction in the percent of relative values was calculated.
The reduction is also observed in young patients with diabetes mellitus ( DM ) .
The reduction of apoptosis markers can promote the persistence of activated cells involved in chronic conditions.
The reduction of bond strength was accompanied by the degradation of collagen.
The reduction of CSC self-renewal via EZH2 inhibition offers a potentially attractive therapeutic approach to counter the aberrant activation found in lymphoma and leukemia.
The reduction of full-length TDP-43 level in mutant SOD1 cells indicates that at least some SOD1 mutations alter TDP-43 metabolism.
The reduction of muscle mass in the elderly is widely studied as one of the most important landmark of human aging.
The reduction of plasticity with age has been shown by many previous papers in animal experiments.
The reduction of sialylation did not have any effect on proliferation , migration , or induction of cellular senescence.
The reduction of the dose of NSAIDs may mitigate , but not avoid , the risk of CV adverse effects.
The reduction rate of oxidized hPTEN was monitored in S. cerevisiae mutants in which the genes involved in redox homeostasis had been disrupted.
There exists a broad array of endoscopic procedures with varying inherent risks that must be weighed with each elderly patient in mind.
There exists a number of noninvasive electrophysiological methods investigating the excitability and plasticity of this pathway.
There exist several dozen lines of transgenic mice that express human amyloid-β protein precursor ( AβPP ) with Alzheimer's disease ( AD ) -linked mutations.
There exists strong evidence for the critical role of the glycolytic pathway's rate limiting enzymes in promoting immunosuppression.
The reference group BMI is an important factor in establishing COPs for low muscle mass.
The reference group was employees aged 18-32 years with low physical exposure.
The reference group was @number@ psychiatrically healthy elders.
The reference interval was defined as the central @percent@ range , and was determined based on age and gender.
The reference list of all the identified articles was also searched for additional studies.
The reference lists of all included articles were also examined.
The reference lists of all the relevant studies and existing reviews were screened for additional relevant publications.
The reference lists of identified articles were then screened.
The reference lists of included articles were screened for further reviews.
The reference lists of relevant articles were also searched for appropriate studies.
The reference lists of selected articles were also reviewed to identify other relevant studies.
The reference standard for delirium was a comprehensive psychiatrist assessment using Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition , Text Revision criteria.
The reference standard was the frailty phenotype measured at visits @number@ and @number@
The reference values for these parameters were determined.
The reflection component has been found to be sensitive to cochlear damage.
The reflection of an ultrasound ( US ) wave is strongest when the propagation direction of the wave is perpendicular to muscle fascicles.
The reflective lifeworld approach , based on phenomenological philosophy , was used to analyse the collected data.
The reflexive , information-integration system is striatally mediated and operates by implicitly associating perception with actions that lead to reinforcement.
Therefore , a better understanding of the function and regulation of estrogen-responsive genes provides insight into the gene regulation network associated with breast cancer.
Therefore , accurate assessment of the glomerular filtration rate is important.
Therefore , accurate evaluation of mitral valve anatomy and function are pivotal to the success of these therapies.
Therefore , a count of the nine other diseases was used.
Therefore , a decrease in benzodiazepine use is expected , particularly in prolonged use.
Therefore , aged participants appeared to activate an insufficient antioxidant response against hypoxia-related oxidative stress.
Therefore , ageing is probably a highly polygenic trait.
Therefore , age-specific work design and interventions are inevitable to create a work environment that sustainably promotes health and well-being.
Therefore , aging is frequently accompanied by reduced social support , which might affect health status.
Therefore , a high serum testosterone level may not mandate adjustment of PSA values.
Therefore , alcohol ingestion as well as smoking is a significant risk factor for CSA in Japanese.
Therefore , a link of MS with mitochondrial dysfunction has been suspected since long.
Therefore , also with this particular mutation , the elevated clinical variability described among GRN-mutated FTLD cases is confirmed.
Therefore , alternate mechanisms might exist.
Therefore , alternative approaches that can circumvent these limitations are needed.
Therefore , a method for retrospective determination of temperature of stored beer was developed.
Therefore , among middle-aged and young-old adults , sexual well-being may be reduced by harboring negative ageist sexual attitudes.
Therefore , among middle-aged and young-old adults , sexual well-being may be reduced by harboring negative ageist sexual attitudes.
Therefore , a more extensive investigation of supercentenarian populations might provide insight into successful brain aging.
Therefore , a more precise definition of NF is required.
Therefore , a multimedia screening system is necessary.
Therefore , an adequate glycemic control is mandatory in diabetes to preserve bone health.
Therefore , analyses of existing cohort studies measuring cognitive outcomes could benefit from methods to ascertain a retrospective delirium diagnosis.
Therefore , analysis of signals that reflect integrated function may be useful in probing dynamical changes in this syndrome.
Therefore , an analysis of consequent repeats of the same experiments in the same biological conditions yields the whole degenerate manifold of possible Gompertz parameters.
Therefore , an early onset of an anti β-amyloid strategy may additionally be potential in preventing aging-associated cholinergic deficits and cognitive impairments.
Therefore , an easily wearable device or instrumented garment would be valuable for monitoring elderly people's postures and activities to facilitate healthy aging.
Therefore , a need exists for efficient nonsubjective monitoring methods.
Therefore , an increase in LA size that occurs before the eighth decade is likely to represent a pathological change.
Therefore , a nonsurgical , minimally invasive , and toxin-free approach to eliminate facial hyperdynamic lines is desirable.
Therefore , a novel mechanism is presented how proteolytic collagen cleavage may inhibit HA synthesis in dermal fibroblasts during extrinsic skin aging.
Therefore , antioxidant and anti-inflammatory factors of the diet , such as vitamin K1 , could play a protective role.
Therefore , a patient-centered approach is needed.
Therefore , a plethora of prognostic factors has been identified to allow a better prediction of the individual prognosis of a given patient.
Therefore , a promising alternative strategy is to maintain a healthy neuronal population in the aging brain for as long as possible.
Therefore , AQP4 immunoreactivity may distinguish NMO from MS neuropathologically.
Therefore a reliable model of cellular senescence remains an indispensable tool for the investigation of senescence-associated changes and human disease.
Therefore , a restricted cubic spline model was developed to account for the non-linear decline with age.
Therefore , a rise in elder homicide is expected.
Therefore , arterial stiffness has the potential to be an important therapeutic target in the management of isolated systolic hypertension.
Therefore , a sensitive and specific detection method is required for the telomere DNA.
Therefore , a simple test such as the Stroop test could differentiate groups of younger and older subjects based on magnetic resonance imaging metrics.
Therefore , assessment of the nutritional status should be included in the comprehensive assessment of AD patients.
Therefore , associated factors must be determined to permit risk-reduction approaches.
Therefore , as the population ages , the impact of AD on the healthcare landscape will increase.
Therefore , as the usage of TST increases , clinicians will be challenged to maintain an up-to-date understanding of TD and TST.
Therefore a strong need exists to identify strategies that facilitate program implementation and sustainability.
Therefore , a study was carried out to find prevalence and risk factors of E. granulosus in yaks , Tibetan pigs and Tibetans.
Therefore , at least two monthly PRP injections may be beneficial for treating patients with minor to moderate knee OA combined with supra-patellar bursitis.
Therefore , at present , it seems that for most patients , best ( intensive ) medical treatment is the best option.
Therefore , autocrine / paracrine actions of adiponectin in the testis may contribute to support male reproductive function.
Therefore , autophagy modulation might be a potential therapeutic method to treat disc degeneration.
Therefore , AZM may be another first choice of antibiotic treatment for patients with aspiration pneumonia when they have no risk of multidrug-resistant pathogens.
Therefore , BCX can be used as a chemopreventive agent or a chemotherapeutic compound against lung cancer.
Therefore , besides the known anti-oxidant activity of Phyllanthus emblica fruits , dietary AR also enhances cellular levels of Hsp27.
Therefore , betaine suppressed the cytokine interleukin-1β production by inhibiting the activation of the NLRP3 inflammasome via interaction of FOXO1 and TXNIP.
Therefore , body fluid-specific differential DNA methylation is a promising indicator for body fluid identification.
Therefore , both future studies and clinical practice may benefit from regarding comorbidity as a modifiable factor with a possibly fluctuating influence on LOAD.
Therefore , both p53 and p73 are critical in apoptosis induced by DNA damage and differentiation.
Therefore , CaHA and HA fillers may be considered complementary rather than competitive to each other.
Therefore , CB1 receptors should be further assessed as a potential therapeutic target in AD.
Therefore , CCO activity analysis may be useful for age estimation in forensic cases.
Therefore , CD14 may represent a promising target for preventing BMDM dysregulation , and macrophage accumulation may provide diagnostic and therapeutic clues.
Therefore , CD57 can apparently be upregulated on activated human T cells by mere contact with CD57 + target cells.
Therefore , cell kinetic alterations during colorectal cancer development show uncontrolled rejuvenescence as opposed to the controlled cell growth in juvenile colonic epithelium.
Therefore , cell replacement and targeting of the molecular systems found in skin hold great promise for controlling or even curing skin aging.
Therefore , cellular senescence has been assumed to be a potent anticancer mechanism.
Therefore , changes in photoaging include wrinkling , elastosis , actinic keratoses , irregular pigmentation , telangiectases , and the development of malignant skin tumours.
Therefore , cholinergic systems appear to enable adaptation to injury even as they degenerate , which has implications for functional restoration.
Therefore , clarification of the relationship between trunk co-activation and locomotor instability will be helpful for developing optimal rehabilitation of elderly people to prevent fall.
Therefore , clinical judgment should be used in applying the dose and the type of those drugs.
Therefore , clinicians should objectively test patients.
Therefore , CLL patients should be treated in clinical trials whenever possible.
Therefore , collaboration among industry , government , and academia should be encouraged.
Therefore , collaboration between ophthalmologists and physicians is mandatory.
Therefore , collagen membranes have adequate properties for further in vivo investigations for orbital floor reconstructions.
Therefore , combinations of resveratrol with other phytochemicals may lead to potential novel potent therapies for both obesity and osteoporosis.
Therefore , combination therapeutic strategies might be more effective than a single strategy for promoting functional recovery after SCI.
Therefore , compilation of data and comparison of results from studies utilizing different measures of baseline brachial diameter may be able to be conducted.
Therefore , compound @date@ be a promising lead compound to further develop a PD therapeutics based on LRRK2 kinase inhibition.
Therefore , conservative treatments such as chemical pleurodesis are frequently performed for inoperable patients with intractable SSP.
Therefore , continuous efforts in this direction are necessary before translating the knowledge to any therapeutic strategies.
Therefore , contrary to current belief , the metabolic effects produced by SRT1720 require AMPK , which can be activated independently of Sirt1.
Therefore , conversion from reversible arrest to senescence ( geroconversion ) is suppressed.
Therefore , copper homeostasis is tightly regulated by cells and tissues.
Therefore , cortical T1 might be a promising additional imaging marker for future longitudinal PD studies.
Therefore , crowns with worn or damaged surfaces may not be able to be assessed , potentially limiting sample sizes.
Therefore , cTnI hs-ARCH may be a useful method for evaluation of prognosis in patients with CHF who often have impaired renal function.
Therefore , D2O has unrivaled utility to quantify day-to-day MPS in humans and inform on short-term changes in anabolism and presumably catabolism alike.
Therefore decisions concerning elderly and smaller subjects concerning remuneration due to impaired lung function after industrial exposure on the basis of EGKS values are questionable.
Therefore , dermal rejuvenation therapies may play a significant role in preventing the initiation of skin cancer in geriatric patients.
Therefore , despite using low mechanical load , LI-VRT is a potentially effective training alternative to traditional HI-RT for enhancing bone health in older men.
Therefore , detecting corresponding changes of COMT expression in estrogen-responsive cells may be a useful method to estimate estrogenic effects of various compounds.
Therefore , detecting occupational risk factors , standards of work position , regular exercise and following ergonomic policy are intensely recommended.
Therefore , determining the levels of sex hormones may be useful for risk stratification and may open a new window for preventive interventions.
Therefore , developing interventional strategies to prevent depression might be a fruitful approach in order to delay functional impairment in old age.
Therefore , development of an HDAC / PI3K dual inhibitor is reasonably attractive.
Therefore , different cut-off values may be needed in some groups of older subjects.
Therefore , different indications for thrombolytic treatment are in use for stroke patients on warfarin.
Therefore , diffusion will occur at a different concentration gradient in each treatment cycle subsequent to the injection.
Therefore , dissection of the broad bipolar phenotype in genetic studies could actually generate new findings that could index novel biologic pathways underlying bipolar disorder.
Therefore , drug and cell therapies aimed at suppressing post-stroke inflammation have emerged as a promising approach to improve recovery after stroke.
Therefore , drug dosage in children should also be based on eLBM rather than weight.
Therefore , DSCs may provide an ideal source of stem cells that can further extend their therapeutic application in nerve injury and neurodegenerative diseases.
Therefore , D-β-Asp-containing proteins in pterygia may responsible for the fibrovascular changes seen in the disorder.
Therefore , early diagnosis and treatment of predisposing cardiovascular risk factors is warranted in this population.
Therefore , early onset preeclampsia is associated with placental aging.
Therefore , early pharmacotherapy is of great significance in prevention or slow-down of the progression of CAVD.
Therefore , effective measures should be taken to prevent and control HEV infection in Tibet , China.
Therefore , effective strategies to prevent or treat lung disease are likely to increase healthspan as well as life span.
Therefore , efforts are needed to limit or decrease the prescription of medications that have been associated with risk of dementia in the elderly.
Therefore , elderly individuals should be closely monitored for the occurrence of renal disorder when they are subjected to polypharmacy.
Therefore , elderly patients with decreased maximum IVC and increased respirophasic IVC collapsibility may need prevention for dehydration.
Therefore , elderly people with certain disabilities should be considered for suicide prevention interventions and should be supported in IADL as much as possible.
Therefore , elucidating the roles of TRP channels in stroke could shed light on the development of novel therapeutic strategies and ultimately improve stroke outcome.
Therefore , elucidation of the molecular and cellular mechanisms of tendon aging will be essential for the development of TDSC-based therapies.
Therefore , end-stage characteristics of EMRA CD8 ( + ) T cells are stringently controlled by distinct and reversible cell signaling events.
Therefore , epidemiological data on older Okinawans , who experienced a caloric restriction-like diet for close to half their lives , are of special interest.
Therefore , epigenetics may play a role in cell senescence.
Therefore , even in prehospital situations , analgesic therapy appears to be reasonable.
Therefore , exclusion of organic diseases , using several investigations , is of paramount important in the older patients.
Therefore , expression of SRD5A2 is not static and ubiquitous in benign adult prostate tissues.
Therefore , falling diastolic BP and increased pulse pressure are associated with increased ICA pulsatility index , which in turn is associated with WMH.
Therefore , FD-ASOCT is expected to become a valuable technique in dry eye screening and diagnosis.
Therefore , for optimal protection against skin damage , sunscreen formulations should filter all UV wavelengths , including UV-A1 irradiation.
Therefore for the assessment of upper-limb function , we should take into account the influence of age.
Therefore , free EAA supplements may aid in the prevention and treatment of muscle wasting in this patient population.
Therefore , from the perspective of an elderly person and senior care , it is crucial to identify determinants of effective coping with chronic pain.
Therefore , further analysis of Koreans with CADASIL might be necessary to implement a Korean-specific mutation screening paradigm.
Therefore , further placebo-controlled trials are necessary to determine the most efficient strains , doses , and the optimal treatment duration.
Therefore , further work based on a more realistic models is necessary.
Therefore , future studies should investigate the underlying physiological mechanisms of prefrontal and cardiovascular changes related to aging.
Therefore , gaining a better knowledge of mechanosignaling events in endothelial cells may prove to be beneficial for developing potential therapies for cardiovascular diseases.
Therefore , GDF11 is a critical rheostat for bone turnover and a key integrator of bone homeostasis.
Therefore , genome-wide mapping of DMRs across various temporal and spatial methylomes is important in revealing the impact of epigenetic modifications on heritable phenotypic variation.
Therefore , geriatric trauma is becoming more prevalent.
Therefore , germ stem cells play a pivotal role in rejuvenation of adult tissues as well as regeneration of damaged organs.
Therefore , greater understanding of the regulation of FOXO target specificity is still needed to boost its use as a therapeutic target.
Therefore growth factors and cytokines in the connective tissue around the SC are major influences in the decline of SC function with age.
Therefore , HDS can be recommended for academic and pathologic purposes in cervical disc degeneration.
Therefore , HIF1α represents a potential therapeutic target to prevent osteoclast activation and bone loss in post-menopausal patients.
Therefore , high intensity should be included to compare elderly and young voice.
Therefore , hip replacement surgery should be considered and effective nursing care should be provided to improve the recovery of older adults.
Therefore , HMSN-P is not confined to the Far East and may simply not have been diagnosed in other populations.
Therefore , IDA provides both comprehensive data resources and analytical tools for understanding potential roles of ARS / AIMPs in cancers.
Therefore , identification of biomarkers that will help screen the population at risk is urgently needed.
Therefore , identification of sirtuin interacting proteins could be a useful aid in focusing the search for substrates.
Therefore , identifying biomarkers that can be easily assessed within the clinical setting and predict cognitive decline is important.
Therefore , identifying treatable risk factors for falls in this population is very important.
Therefore , IFN-α can inhibit the enzyme telomerase in CD8 ( + ) T cells by transcriptional and posttranslational mechanisms.
Therefore , if people age in better health , medical spending may be significantly reduced.
Therefore , impaired cortical connection is substantially a global process affecting various major tracts simultaneously.
Therefore , improvements in air quality may promote molecular longevity from birth onward.
Therefore , in a busy practice , geriatric screening tools are useful to identify patients in need of further evaluation using a full GA.
Therefore , in addition to treating illnesses , physicians and other healthcare professionals are often faced with managing secondary mental health consequences.
Therefore , in a first approach , the C-terminal benzamidine of MI-1148 was replaced by less basic P1 residues.
Therefore , in a second part this review will introduce several examples for the application of clinical proteomics to aging itself and age-related diseases.
Therefore , in designing interventions , socioeconomic inequalities should be taken into account through the use of multi-dimensional measurement tools.
Therefore , inherited CPC variability could influence tumor development.
Therefore , inhibition of PAPP-A represents a novel approach to indirectly decrease the availability of bioactive IGF.
Therefore , inhibition of the tau aggregation is one of the key approaches for the treatment of these diseases.
Therefore , initiation of treatment should rely more on symptoms and less on a discrete numerical threshold.
Therefore , in older individuals , the semantic and phonological routes seem to merge into a single pathway.
Therefore , in order to detect and treat age-associated hypertension appropriately , it is important to assess ambulatory blood pressure monitoring throughout the 24-h period.
Therefore , in order to improve QOL and mental health in older women , the understanding and management of urinary incontinence interventions is required.
Therefore , in recent years , research has begun to investigate epigenetic mechanisms for a potential role in disease etiology.
Therefore , instead of being permanently hungry , a prolongation of human life could be achieved by a replacement melatonin therapy.
Therefore , instead of merely subsidizing transportation expenses , transportation services must be improved.
Therefore , instead of providing evidence of ' true ' health disparities across groups , findings may actually reflect reporting heterogeneity.
Therefore , intensity-thresholds were created for both men and women of ranging VO2max values ( low , medium , high ) .
Therefore , interest is growing to evaluate the effects of interventions aiming at preventing cognitive decline and , ideally , dementia onset.
Therefore interpretation of presepsin concentrations might be altered in the elderly or in patients with impaired renal function.
Therefore , in the nucleus a special PARP-1-mediated mechanism of proteasomal activation exists to ensure a rapid degradation of oxidized nuclear proteins.
Therefore , in this article we describe platelet hyperactivity by AGEs via RAGE-independent and RAGE-dependent pathways.
Therefore , in this mouse model , age-related accumulation of 8-oxoguanine in RNA is correlated with decreased expression of MTH1.
Therefore , in this study , we immunolocalized NRF2 in @number@ breast carcinoma cases.
Therefore , intravenous vernakalant provides an effective option for the management of recent-onset atrial fibrillation.
Therefore , investigating the inhibiting mechanisms of photoaging would be useful to enable development of agents to slow down the aging process.
Therefore , investigations in additional study populations are needed before final conclusion can be drawn.
Therefore , is it essential to develop and use relevant animal models to further the research on sarcopenia therapy ?
Therefore , isonitramine may be a new drug candidate for the treatment of diabetes mellitus.
Therefore , it becomes crucial to understand how senescent cells function and how they contribute to the aging process.
Therefore , it becomes increasingly challenging to select the right treatment strategy for each condition.
Therefore , it becomes increasingly challenging to select the right treatment strategy for each condition.
Therefore , it can be used for assessing attitudes toward aging among older adults.
Therefore , it has often been regarded as not posing a significant health hazard.
Therefore , it is a challenge to select the most appropriate therapy for an elderly patient.
Therefore , it is critically important to study alternative treatment strategies.
Therefore , it is difficult to control long term experimental culturing conditions.
Therefore , it is easy to understand why recent literature focuses on the epigenetic modifications associated with Alzheimer's disease and other neurodegenerative disorders.
Therefore , it is essential to understand the relationship between protein oxidation , intracellular proteolytic systems and cellular defence mechanisms.
Therefore , it is feasible and convenient to analyze these hemoglobin modifications from DBSs in studies involving large populations.
Therefore , it is highly desirable to develop computational methods to identify antioxidant proteins.
Therefore , it is imperative to develop effective therapeutic strategies to contend with this significant issue.
Therefore , it is important for us to identify agents that have anti-oxidant properties to protect skin against free radical damage.
Therefore , it is important to define the distinctive characteristics of the EC that make this region particularly vulnerable.
Therefore , it is important to detect SDB in the early stages.
Therefore , it is important to know both the extent and limitations of this association.
Therefore , it is important to understand how adaptive genetic variations interact with environments to influence health.
Therefore , it is important to understand how the environment may influence the measurement to ensure the highest level of accuracy.
Therefore , it is important to understand the underlying pathogenic mechanisms of this syndrome.
Therefore , it is important to understand what insults can lead to mitochondrial dysfunction in order to promote cell health and increase cellular viability.
Therefore , it is likely that stem cells give rise to new cells that replace senescent cells.
Therefore , it is necessary to conduct experimental studies in a human model.
Therefore , it is necessary to consider molecular interactions to correctly and specifically annotate biological networks.
Therefore , it is necessary to support the elderly and caregivers in ways that suit their ethnic characteristics.
Therefore , it is necessary to understand the difficulties older pedestrians encounter.
Therefore , it is not surprising that postoperative ileus ( POI ) affects patients of all ages.
Therefore , it is of great importance to study the mechanical properties and model the response of these ligaments.
Therefore , it is of particular importance to diagnose and to treat hearing and vision loss ( dual sensory loss ) as early as possible.
Therefore , it is particularly important to confirm that the correct inhalation procedure is used by elderly female patients with asthma.
Therefore , it is possible that other forms of innate or acquired alterations of the immune system could favor the occurrence of non-melanoma skin cancers.
Therefore , it is reasonable to postulate that these pathways are involved in the increased risk of dementia that occurs in the T2D population.
Therefore , it is reasonable to speculate that metal ions , especially zinc , can modulate the activity of BDNF.
Therefore , it is recommended to consider the HBM to enhance self-care behaviors in the elderly.
Therefore , it is tempting to investigate their use as a tool to improve regenerative medicine strategies in orthopedics.
Therefore , it is unclear for clinicians to which older patients the results can be applied.
Therefore , it is unlikely that hitting a single target will result in significant benefits to patients with AD.
Therefore it is very important and useful to learn macroscopic findings of neurological disorders.
Therefore , it is vital to know the clinical predictive value of self-report pain assessment in this population.
Therefore , it is worthwhile investigating extensively the cardiac substrate in selected cases when the initial evaluation demonstrates its presence.
Therefore it lacks a necessary mean to implement mechanisms of prevention and programming for a disease that increasingly shows significant social - health consequences.
Therefore , it may be important to consider the different fetal developmental stages when linking early life experiences with later health.
Therefore it may be of benefit when both phases are being managed in term of hormonal deficit if antioxidant is an adjunct.
Therefore , it may be possible for us to estimate human age by analyzing mitochondrial activity.
Therefore , it may have positive impact on seniors ' well-being and successful aging.
Therefore , it might be hypothesized that the likelihood of conversion to dementia would be higher within this subtype.
Therefore , it might be responsible for the prevention of testosterone deficiency symptoms to maintain testosterone secretion taking account of the modifiable factors.
Therefore , it remains unclear how an alteration in CBF or its regulation affects cognitive function.
Therefore , its assessment along with other major cognitive functions may be highly beneficial in terms of obtaining a comprehensive neuropsychological profile.
Therefore , its driving force may be controlled by the surface tension and the mobility of the boundaries.
Therefore , it seems to be very important to find other sources of mesenchymal stem cells nowadays.
Therefore , it should be given appropriate consideration in research and clinical practice.
Therefore , it should have no or little adverse effects.
Therefore , it shows promise as a measure for screening the presence of suicidal thoughts among the elderly in long term care facilities.
Therefore , it's strongly recommend that researchers consider and report their realignment methods when assessing upper body variables during gait.
Therefore , it suggests that μ ( PA ) is associated with the decrease in the ANS function accompanied by aging.
Therefore its usefulness as a stand-alone screening tool is limited.
Therefore it was hypothesized that the reduction of melatonin levels with age contributes to the aging process.
Therefore , it was shown in a simulated environment that oxidation can have detrimental effects to the clinically relevant properties of irradiated and melted UHMWPEs.
Therefore , KDCI can be a useful tool to identify incident dementia.
Therefore , klotho protein could be considered as a protective factor against changes caused by altered monocytes in epithelial cells.
Therefore , Klotho up-regulates TRPV5 from both the inside and outside of cells.
Therefore , knowledge about disease-specific pathologies may provide useful guidelines for differential diagnosis of cortical lesions occurring in neurological diseases.
Therefore , larger cytoplasmic volume , with earlier cleavage speed , implies more mtDNA copies.
Therefore , levels of circulating bioactive IGF1 does not appear to be a better biomarker of physiological ageing than total IGF1.
Therefore , lifestyle is predictive of mental health among midlife and older women.
Therefore , long-term aging may be useful to determine a dental material's toxicity.
Therefore , low educational level , associated with aging , may potentialize the risks for language decline.
Therefore , maintaining a functional population of mitochondria is critical for cardiac function.
Therefore , maintaining the environment surrounding working women has become an important priority of the occupational physician.
Therefore , maintenance of normal glucose regulation depends on the ability to compensatory increase of the beta cell function.
Therefore , major efforts have been invested to improve the repair capability of stem cells in aged individuals by overexpressing antisenescence and antiapoptotic genes.
Therefore , manipulating Ca2 + signaling pathways might represent a potential therapeutic strategy for Parkinson's disease.
Therefore , many researches have attempted to search for agents that can accelerate wound healing with safety and biocompatibility to human body.
Therefore , many research groups focused their studies to understand the mechanisms of Rad26p / CSB functions to illuminate the molecular bases of CS.
Therefore , medical professionals should prescribe fewer medications to eliminate adverse drug reactions and reduce depressive symptoms.
Therefore , Meta-analysis approaches were conducted to give more precise estimate of relationship between telomere length and PTSD.
Therefore , metabolic recovery in children with SAM likely extends beyond discharge , which may explain the poor long-term outcomes in these children.
Therefore , metabolism by monoamine oxidase plays an incremental , predominant role in biogenic amine turnover , leading to greater oxidative stress.
Therefore , microsomal prostaglandin E synthase ( mPGES-1 / -2 ) , is a potential target for cancer therapy.
Therefore , minimum estimates of the variance in later-life MHT accounted for by childhood performance on the same test ranged from 26-44%.
Therefore miRNAs might be directly linked to bone tissue homeostasis.
Therefore , mitochondria specific antioxidants such as acetyl-L-carnitine and R-alphalipoic acid seem to be potential treatments for AD.
Therefore , mitochondrion may be the most important determinant of life span.
Therefore , molecules inhibiting SSAO could provide an alternative treatment for preventing / delaying the progress of CAA-AD-associated vasculopathy.
Therefore , more attention must be paid to adapting anti-diabetic treatment in this complex population.
Therefore , more effective tools should be developed.
Therefore , much focus is being placed on the effects of dietary phytochemicals on aging and stress response.
Therefore , mutations of the mitochondrial genome are currently believed to be involved in many common diseases as well as classical mitochondrial neuromyopathies.
Therefore , natural compounds or extracts that possess antiglycation activities may have great anti-ageing potential.
Therefore , negative calcium balance usually means reduction of bone mass.
Therefore , nerve enlargement remains the main diagnostic criterion in high-resolution ultrasound.
Therefore , neuropathological processes other than β-amyloidosis must underlie declines in brain structure and memory function in middle age.
Therefore , new approaches to maintain health for as long as possible in this age group are required.
Therefore , new automatic sleep staging methods , to be used in both of young and elderly patients , are needed.
Therefore , new materials are needed to improve surgical outcomes.
Therefore , new medications to combat type @number@ diabetes are needed.
Therefore , @number@ individuals were analyzed.
Therefore @number@ normal-hearing participants ( @number@ young , Ø @number@.8years ; @number@ older Ø @number@.8years ) were tested.
Therefore , @number@ unrelated sporadic ALS patients , @number@ unrelated familial ALS patients , and @number@ neurologically normal controls were studied.
Therefore , nutritional assessment and early nutritional supplementation should be essential domains in this strategy.
Therefore , nutritional guidance and exercise instruction are extremely important as well as management of diseases in older people.
Therefore , OKG may be of a potential interest to modulate muscle protein metabolism and to maintain muscle mass during aging.
Therefore , old C- subjects are likely to benefit more from zinc supplementation restoring NK cell cytotoxicity and improving the zinc status.
Therefore , older adults may not fully benefit from metacognitive knowledge about sources in source monitoring.
Therefore , older patients with kidney disease are particularly susceptible to the risks of adverse drug reactions.
Therefore , older subjects have a higher CSP after exercise , which is not readily assessed by conventional measurements of BSP.
Therefore , olmesartan might provide a greater long-term benefit for hypertensive patients with impaired endothelial function than amlodipine.
Therefore , only in physically active people can the inherent aging process proceed unaffected by disuse complications.
Therefore , our aim is to investigate the potential protective effects of Hu-Yi-Neng on human neuron cells.
Therefore , our aim was to provide a broad overview of the widely used methods for reducing post-operative blood loss after total hip arthroplasty.
Therefore , our analysis suggests that Subdued channels may amplify the nociceptive neuronal firing that is initiated by thermo-TRP channels in response to thermal stimuli.
Therefore , our case is the first case.
Therefore , our data strongly suggest that CA acts as an anti-inflammatory drug by directly suppressing IRAK1 and IRAK4.
Therefore , our experimental results indicate left hemisphere dominance for Chinese character processing , providing evidence for one part of our model.
Therefore our objective was to study the association between REV-ERB-ALPHA1 rs2314339 and obesity in two independent populations.
Therefore , our results demonstrate that the ER stress-regulated ATF4 / p16 pathway is involved in the premature senescence of RTECs during DN progression.
Therefore , our results indicate that selected genetic polymorphisms in DNA repair genes may influence overall survival in resected NSCLC.
Therefore , our results suggested that frequency-specific QTLs control early-onset hearing loss in DBA / 2J mice.
Therefore , our results suggest that individuals with ASD might be relatively protected from age-related cognitive decline and the risk of dementia.
Therefore , our results validate the use of height among the population aged over @number@
Therefore , our study suggests that suppressing the disease-related genes via epigenetic modification is an important contributor to human longevity.
Therefore , patients at higher risk of adverse outcomes should have higher priority to publicly funded CGA services.
Therefore , patients attending polyclinics were found to have higher AD8 scores compared with patients in GP clinics ( P < @number@ ) .
Therefore , patients injected with Thorotrast comprise a suitable study group to understand biological effects of internal ionizing radiation injury.
Therefore , patients with pyogenic spondylitis treated at two university hospitals were retrospectively investigated to clarify the recent clinical and radiologic characteristics of this infection.
Therefore , PCE may be a potent therapeutic agent targeting abnormal angiogenesis in DN leading to kidney failure.
Therefore , @percent@ of patients ( @percent@ aged ≥ @number@ years ) would not be electively screened.
Therefore , pitch discrimination , as measured by FDLs , and neural representation of frequency , as reflected by FFR , declined as age increased.
Therefore , policy-makers sometimes consider supporting older volunteers.
Therefore , precise regulation of p16 ( INK4a ) is essential to tissue homeostasis , maintaining a coordinated balance between tumor suppression and aging.
Therefore , predicting mortality outcomes in people living with HIV is extremely important as this population ages.
Therefore , preventing mitochondrial dysfunction could be an effective therapeutic strategy against cellular degenerative processes.
Therefore , prevention and treatment of dysphagia would contribute to extending healthy-life and QOL of elderly people and decreasing healthcare cost.
Therefore , primary prevention is very important.
Therefore , proinflammatory monocytes / macrophages ( CD14 + CD16 + ) should be evaluated according to the sex and age.
Therefore , promoting appropriate physical activity among older adults in the community is essential to delaying the health implications of aging.
Therefore , proper control of other vascular risk factors is mandatory in patients with diabetes , in particular of arterial hypertension.
Therefore , proper identification and management of this condition is a major task for clinical geriatricians and geriatric hepatologists.
Therefore , proper management of antimicrobial agents by an antimicrobial stewardship team may lead to decreased incidence of AKI.
Therefore , prospective human resource planning is important to avoid loss of competence.
Therefore , proteostasis maintenance in stem cells might have an important role in organismal aging.
Therefore , PSLs will be potential pharmacological interventions for inflammatory and immune diseases through feedback mechanism utilizing PGE ( @number@ ) .
Therefore , quantitative assessment of lipids in isolated mitochondria is of importance for mitochondrial research.
Therefore , radiation dosimety calculations for commonly used positron-emitting radiotracers in the paediatric population are highly desired.
Therefore , radio ( Sestamibi ) guided surgery could have an ; interesting rule in the thyroid follicular lesion treatment.
Therefore , rather than a numerical impairment , poor numerosity discrimination is likely to reflect elderly's impoverished inhibitory processes.
Therefore , readmission for HF and AMI is receiving increasing attention.
Therefore , reagents that selectively recognize different key morphologies of tau are needed to help define the role of tau in AD and related diseases.
Therefore , recently it has been hypothesized that COPD begins in childhood.
Therefore , recognizing specific symptoms is important to improve support for SMID.
Therefore redox sensitive microRNAs or \ "redoximiRs \ " add an important regulatory mechanism for redox signaling beyond the well-characterized actions of Nrf2.
Therefore , reduced global methylation may play a role in the systemic senescence process.
Therefore , reducing postoperative morbidity and mortality is a major concern in medical research and practice.
Therefore , reduction of ROS-induced oxidative stress via inhibition of MAO-B activity may delay the progression of the disease.
Therefore , registries focusing on adverse reactions to injectable fillers and their treatment should be encouraged.
Therefore , regular aerobic exercise may prevent age-related diseases , increase life quality and prolong life span through regulation of mitochondrial function and redox balance.
Therefore , regular monitoring of growth and dental development might be helpful for targeting support programmes in developing countries.
Therefore , regular oral examinations coupled with early preventive measures should aim at maintaining oral health until old age.
Therefore , reprocessing of RMDs has become more difficult , and issues related to infection risk have become more prevalent.
Therefore , research into therapeutic treatment alternatives or alleviation of these effects on skeletal muscle is of great importance.
Therefore , residents ' assigned plans may be relatively more or less generous for their particular drugs.
Therefore , residents with DSI might cognitively benefit from interventions to improve involvement in social life at nursing homes.
Therefore , resveratrol inhibits melanogenesis through the activation of FOXO3a but not by the activation of SIRT1.
Therefore , risk factors and pathomechanisms of chronic neurodegenerative disorders , including AD , and persistent cognitive dysfunction may overlap.
Therefore , rodents chronically exposed to D-gal are increasingly used as a model for aging and delay-of-aging pharmacological research.
Therefore , ROS production critically affects the survival of the DNA repair mutant during chronological aging.
Therefore , RPE replacement and microenvironmental regulation represent viable treatments for dry AMD.
Therefore , senescence has been suggested to functions as a natural brake for tumor development and plays a critical role in tumor suppression and aging.
Therefore , serum cystatin C level might predict the progression of cerebral WMH.
Therefore , serum E1 is a novel potential risk factor for poor self-rated health in older men that warrants further investigation.
Therefore , services for older people should encompass medical as well as social components.
Therefore , SFN is a promising therapeutic avenue for children with HGPS.
Therefore , SGK- @date@ represent a specific target to further develop novel therapeutic options against chronic diseases such as diabetes typical of aging.
Therefore , similar to the first conceptual issue , it seems unlikely that the capability set adequately reflects SE.
Therefore , since immune cells require iron for proper function hepcidin may also play an important role in immune response.
Therefore , SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.
Therefore , SIRT6 has emerged as a therapeutic target for the treatment of metabolic disorder and age-related diseases.
Therefore , sirtuins became recognized as critical affectors of cellular metabolism which participate in fat mobilization , gluconeogenesis , caloric restriction etc.
Therefore , sivelestat was chosen as the model structure in an attempt to obtain more potent anti-NsPs agents.
Therefore , social interest in the fields of health , longevity , and anti-aging has been increasing as well.
Therefore , some amount of mucin is expected a priori in the reticular dermis of aged patients , even in the absence of clinical lesions.
Therefore , some confusion is still present in the definition and diagnosing criteria of these conditions.
Therefore , special attention should be paid to behavioral problems as part of general management of adults with PWS.
Therefore , spirometric obstruction may clinically be over / under diagnosed.
Therefore , strategies targeting myelin impairment may provide therapeutic opportunities for patients with AD.
Therefore , strategies to prevent / reduce oxidative stress-mediated aging , whether environmental , nutritional and pharmacological , need to be taken into account.
Therefore , studying the basic mechanisms underlying structural and functional recovery after brain injury in aged subjects is of considerable clinical interest.
Therefore , subcortical MD may be an alternative biomarker of brain morphology for complex traits worthy of future investigation.
Therefore , subjects with metabolic syndrome practicing sports and other activities stressing the Achilles tendon should receive advice for more frequent controls.
Therefore , subtle changes in the folding environment that occur during aging can significantly impact the health of the proteome.
Therefore , successful therapy should target several pathological features simultaneously.
Therefore , supplying appropriate in-home services to current nonusers would help to greatly reduce the rate of institutionalization of older people.
Therefore , SynCav1 might be a potential therapeutic target for restoring neuronal function in schizophrenia.
Therefore , tailor-made rather than uniform therapy becomes important.
Therefore taking care of the elderly by detecting activity and falling for preventing and mitigating the injuries caused by falls needs to be concerned.
Therefore , tau protein has been focused recently as the new target for the treatment of Alzheimer's disease.
Therefore , TAVEC seems a fitting , simple procedure with which to measure cognitive plasticity , and an effective indicator of impairment.
Therefore , T cell dysfunction in the elderly may contribute to poor treatment outcomes.
Therefore , TDP-43 mediates stress responses and couples the regulation of RNA metabolism and protein quality control in a FOXO-dependent manner.
Therefore , the ability to coordinate muscle activity around the knee in a timely manner may be critical to avoiding falls from slips.
Therefore , the abrupt onset was unable to capture attention away from the target-color cue.
Therefore , the activation of autophagy through the modulation of nutrient-sensing pathways may be a new therapeutic option for the suppression of diabetic nephropathy.
Therefore , the adjustment of normal ranges in the elderly should be considered.
Therefore the aggravated spatial memory and spatial reference memory deficits of the homozygous mice correlated with the elevated soluble and insoluble Aβ levels.
Therefore , the aim of many researchers is to find out a way to eliminate senescent cells and improve the health condition of aging people.
Therefore , the aim of this study was to assess the antidiabetic effect of M. oleifera extract from Cambodia.
Therefore , the aim of this study was to assess the views , knowledge and practices of professionals in relation to this issue.
Therefore , the aim of this study was to explore possible factors associated with fatigue among persons with late effects of polio in Sweden.
Therefore , the aim of this study was to investigate the status of aforementioned parameters in elderly physically disabled patients vs. healthy ones.
Therefore , the aim of this systematic review is to examine the relationship between attitudes towards menopause and symptom experience using original research studies.
Therefore , the aim was to establish for the first time collaborative recommendations for these patients.
Therefore , the antioxidant E-AP-SM2001 may serve as a predictable functional ingredient.
Therefore , the authors introduce a novel method of inserting a small strip of acellular dermal matrix ( ADM ) underneath the wrinkle line.
Therefore , the authors recommend that clinicians use a ceramic primer when cementing zirconia restorations.
Therefore , the authors suggest that @number@ familiarization sessions be performed to correctly assess PT.
Therefore , the benefit of vitamin E as a treatment for neurodegenerative disorders is still under debate.
Therefore , the capacity of LTL to predict arterial stiffness was examined.
Therefore , the clinical management of diabetic retinopathy and diabetic maculopathy in elderly patients with diabetes is increasingly becoming more important.
Therefore , the clinical management of ED related to aging can be done by therapeutic interventions that include PDE-5 inhibitors , and other pharmacological treatments.
Therefore , the concept does not only consist of people's own perceived efforts , but also includes the influence of external sources.
Therefore , the concept of a dual axis of RAAS regarding glucose homeostasis has emerged.
Therefore , the current study was designed to assess the immunohistochemical changes in neurodegenerative markers in patients with BPD.
Therefore , the development of alternate therapies for treating hypogonadism would be highly desirable.
Therefore , the development of curative modalities such as gene therapy is imperative.
Therefore , the dysregulated cytokine production could contribute to immune senescence in the elderly.
Therefore , the early identification of possible risk factors and the establishment of preventive and treatment strategies for dementia have become increasingly important.
Therefore , the effects of FRIDs on postural control were examined by reviewing literature.
Therefore , the effects of gonadal hormones on the aging brain are important to consider.
Therefore , the effects of the aged milieu on these cells and their intrinsic aging in vivo are important considerations.
Therefore , the elderly will benefit more of treatment.
Therefore , the elderly with RA should be considered a different patient population from the viewpoint of treatment and be administered specialized medical care.
Therefore , the equations can be used to predict 1RM from submaximal skeletal muscle strength accurately for older adults.
Therefore , the equipment we developed could potentially be useful in the assessment and monitoring of balance and the risk of falling in older people.
Therefore , the establishment of a nomogram of AFC values is the first step to counsel patients on a scientific basis.
Therefore , the explanation for the differences must be studied further with respect to elements that are distinctive for each device.
Therefore , the expression level of glutamate transporters could be important in essential tremor pathogenesis.
Therefore , the extent of forward scattering and its influence on macular visual acuity could be important components of ophthalmological evaluations of cataract patients.
Therefore , the further increase of epidemic-like incidence of malignant tumors in a population can be expected in the near future.
Therefore the future orientation of EU social policies should aim to reduce the impact of these social determinants on health equity.
Therefore , the goal of the present study was to assess the prevalence and characteristics of UR in French adults.
Therefore , the goal of this study was to empirically map this legal terrain.
Therefore , the HRV can be considered reliable in professional soccer players and is able to differentiate between international- and national-level players.
Therefore , the IC network represents a unique candidate for viable therapeutic intervention and should become a high priority for research in AD.
Therefore the identification , characterization and discovery of potent MAO-A and B inhibitors is very crucial in research.
Therefore , the impact of different factors , such as physical activity , on work ability is of interest.
Therefore , the impact of FMR1 CGG repeat on ovarian reserve is needed to be investigated in large Chinese cohort.
Therefore , the indication of polysurgery for intractable pneumothorax is controversial.
Therefore , the initial response component might be an objective parameter for investigating change in lip function with age.
Therefore the interpretation of plasma CTproET-1 levels in such individuals should take into account these variables to avoid potential confounding.
Therefore , their determination would not allow us to predict the IVF / ICSI outcome with sufficient specificity and sensitivity.
Therefore , the joint effect of rs6214 and rs2854744 was analyzed.
Therefore ; the lack of efficient pharmacotherapies is evident in such patients.
Therefore the main problem is how to maintain the aging population in good health and promote and improve their working life and social integration.
Therefore , the main thrust of this paper is to provide an overview of the current clinical evidence and significance of miR-21 in HTN.
Therefore , the management of BW may contribute to prevention of decline of tibial BMD for TKA patients owing to aging.
Therefore , the Mediet may be considered as including several nutraceuticals that favourably influence health.
Therefore , the metabolic activity of bone and the energy-related organs like fat and islets are closely linked by circulating OCN.
Therefore , the microcirculation may be considered an essential target for both the pharmacological and non-pharmacological treatment of arterial hypertension and other cardiovascular diseases.
Therefore , the molecular components of the pathways activated by the sexual steroids could represent targets for anti-aging therapies.
Therefore , the need to find effective preventive means is pressing.
Therefore , the NET is suggested to play a critical role in ADHD.
Therefore , the NO-cGMP pathway is a treatment target in heart failure.
Therefore , the NP-related fraction of NFT appears to be co-localized spatially with NP.
Therefore , the objective of this study was to describe the prevalence of potential drug-drug and drug-disease interactions and associated factors in community-dwelling older adults.
Therefore , the objective of this study was to identify age-specific differences in the Achilles tendon-muscle complex using an animal model.
Therefore , the objective of this study was to investigate the association between ankle muscle co-contractions and postural steadiness during standing in the elderly.
Therefore , the optimal management of this group of women remains less certain.
Therefore , the parotid duct is important to maintaining a healthy oral cavity.
Therefore , the period just prior to menopause , also known as the subfertile period , is important.
Therefore , the possibility of developing antiaging interventions for humans has gone from a dream to a reality.
Therefore the precise molecular diagnosis of familial hyperchylomicronemia may affect treatment decisions.
Therefore , the pre-participation physical examination offers a unique opportunity to screen athletes for metabolic bone disease through the history and physical examination.
Therefore , the presence of COPD in CHF patients should be considered a relevant factor in predicting high risk of mortality.
Therefore , the present explorative study examines the effects of normal aging on multiple aspects of FDM.
Therefore , the present review focuses on the impact of mitochondria in the ageing process of heart and skeletal muscle.
Therefore , the present study aimed to examine the dyadic effects of attitude toward aging on the psychological well-being of older couples.
Therefore , the present study indicates the pharmacological basis for treatment of atherosclerosis with DTD.
Therefore , the present study investigated the relationship between bone mineral densitometry measurements , bone markers , endocrine hormones and blood lead levels.
Therefore , the present study shows that compound @number@ prevents collagen degradation in aged rat skin and UVB-exposed fibroblasts through PPARβ / δ activation.
Therefore , the present study was designed to investigate the role of mitochondrial retrograde signaling in isoflurane-induced hippocampal neuroinflammation and cognitive impairment in aged rats.
Therefore , the present study was done to determine the effect of a healthy lifestyle program on elderly's health in Arak.
Therefore , the prevention and treatment of atherosclerosis that causes these ischemic organ dysfunctions is indispensable.
Therefore , the promotion of such lifestyles is likely to help prevent CRLDS in this population.
Therefore , the purpose of the study was to examine the determinants of financial performance of home-visit nursing agencies.
Therefore , the purpose of this meta-analysis is to systematically review and determine whether vascular SMF is different between older versus young healthy individuals.
Therefore , the purpose of this project was to examine the feasibility of using MMG and muscle performance measures to noninvasively assess muscle fiber characteristics.
Therefore , the purpose of this review will be to examine the role of sex hormonal status in the development of sarcopenia.
Therefore , the purpose of this study is to examine this relationship in the very old.
Therefore , the purpose of this study was to determine whether there are differences related to obesity and aging on required friction during overground walking.
Therefore , the purpose of this study was to investigate the effects of cocoa-intake frequency on arterial stiffness in postmenopausal women.
Therefore , the purpose of this study was to investigate the risk factors for POPF after DP using a triple-row stapler.
Therefore , the purpose of this study was to present muscle architecture of the upper and lower limbs of a @number@ year old female cadaver.
Therefore , the purpose of this study was to validate the Chinese Revised Algase Wandering Scale-Community Version ( CRAWS-CV ) in northern Taiwan.
Therefore , the question arises whether to treat older men whose serum testosterone is low.
Therefore , therapeutic interventions which possess thymopoietic potential and lower thymic atrophy are required.
Therefore , therapy with 5-ARI could be considered as neoadjuvant to surgery , whatever this is.
Therefore , the recruitment of undergraduate students into gerontology programs is an important , although challenging task.
Therefore , the reduction of the expression of RORα could represent a potential warning sign of colorectal cancer.
Therefore , the regression coefficients associated with the mean effect of time on hearing ability will be constrained.
Therefore , there have been many attempts to employ antioxidants treat inner ear damage.
Therefore , there is a need to further examine the mechanism of FCR.
Therefore , there is a need to further improve and strengthen the integrated community care system.
Therefore , there is a need to recognize the existence of AD in elderly CU patients.
Therefore , there is a pressing need for novel therapeutic modalities.
Therefore , there is considerable interest in unraveling the pathways by which estrogen exerts its protective effects on bone.
Therefore , there is expanding social demand for the development of better rehabilitation treatment of dysphagic patients.
Therefore , there is great interest in understanding mitochondrial metabolism and the complex relationship it has with other cellular processes.
Therefore there is increased expectation that therapeutics can be developed that act in some fashion to suppress reactive oxidant species and ameliorate the condition.
Therefore , there is little or no evidence to guide the use of positive inotropes in older patients with HFrEF.
Therefore , there is significant merit in better understanding the biology of sarcopenia and developing therapeutic interventions to prevent , slow or reverse its progression.
Therefore there is still a need for new and effective oral agents in the combination therapy of lipid disorders.
Therefore , the relationship between the GXXXG motifs , substrate dimerization , and γ-secretase-dependent cleavage sites remains unclear.
Therefore , the restoration of facial volume and contour changes has become an important treatment approach in aesthetic dermatology in recent years.
Therefore , the results and the arguments presented in this paper throw light on the finer nuances of the science of aging.
Therefore , the results of our systematic review and meta-analyses should be interpreted with caution.
Therefore , the results suggest the possibility that Aβ may promote NFT maturation and induce synaptic dysfunction through the disturbance of actin assembly.
Therefore , the role of genetic factors on bone loss may also change similarly.
Therefore , the role of vitamin E as an ' anti-ager ' has been called into question.
Therefore , the R. rosea extract and salidroside deserve further study as novel agents for chemoprevention of bladder carcinogenesis.
Therefore the safety and efficacy profile of intravenous zanamivir ( IVZ ) was examined in Japanese patients with severe influenza.
Therefore , the safety and photo-stability in the development of RA or ROL derivatives have been an important issue.
Therefore , these agents are strongly recommended when dealing with elderly patients suffering from an invasive form of Candida infection.
Therefore , the second objective was to assess the executive involvement in the priming task.
Therefore , the secretome would be primarily responsible for SC effects.
Therefore , these data successfully demonstrate the involvement of senescence gene in the expression of stemness markers and osteogenic potential of MSCs.
Therefore , these differences have to be considered when targeting proteins for therapeutic approaches.
Therefore , these findings suggest that scopoletin could exert a positive effect on anti-aging related to autophagy through modulation of p53 in human lung fibroblasts.
Therefore , these long-lived mice enjoy a longer period without suffering the various sequelae of ageing.
Therefore , these parameters may be used for additional testing in diagnostics of the risk of ischemic complications and repeated thrombosis.
Therefore , these processes may serve as protective mechanisms for the RPE.
Therefore , these proteins do not contribute to the sensor's surface potential change.
Therefore , these studies are assigned as ' awaiting classification ' in the review until sufficient information can be obtained from the authors.
Therefore , the simple but well-established Drosophila model-system provides an alternative for investigating the molecular pathways that are affected in these diseases.
Therefore , the study of dysregulation trajectories should allow important insights into aging physiology and provide clinically meaningful predictors of outcomes.
Therefore , the supine position can be recommended for the diagnosis and therapy of weakened PFM.
Therefore , the synergies of upper extremity movement may not be impaired for machine-paced tasks as people age.
Therefore , the term ageing not only reflects the lifespan of an organism but also refers to progressive functional impairment and disease.
Therefore , the thickness of the LF should be measured and evaluated carefully in the case of spinal stenosis.
Therefore , the transition speed and associated number of poses should be considered when targeting specific improvements in performance.
Therefore , the treatment of geriatric depression is necessary.
Therefore , the use of objective measures of FM distribution may not be necessary to examine the impact of FM distribution on mobility.
Therefore , they are effective in MS assessment in the elderly and during follow-up for individual and collective clinical practice.
Therefore , they need special attention from family , policy makers , and those who work with elderly people.
Therefore , they need to be adapted when used in a non-US hospital setting.
Therefore , they now need to be tested with novel agents.
Therefore they should not be considered benign.
Therefore , this compound might be effective in alleviating chronic low-grade inflammation linked to age-related degenerative disorders.
Therefore , this condition is easily overlooked.
Therefore , this enzyme could play an important role in brain inflammation and neurodegeneration.
Therefore , this group of patients should be given special postoperative monitoring and , in particular , intensive respiratory rehabilitation immediately after reconstitution.
Therefore , this innovative-fluorescent fusion protein would be useful for NIR-based imaging in vitro and in vivo.
Therefore , this material shows promise as a pulp capping material for vital pulp preservation in the treatment of deep caries.
Therefore this new parameter resembles large artery PWV.
Therefore , this population would be the one who would benefit most from the prevention , detection and control of DRP.
Therefore , this research aims to determine the differential gene expression profile in related individuals from villages in Pahang , Malaysia.
Therefore , this review will focus on the role of these two proteins in cardiovascular aging.
Therefore this study addresses the differences of biomechanical properties of the triceps surae muscle-tendon unit between young and postmenopausal women.
Therefore , this study aimed to analyse how ageing affects key mechanisms that regulate intracellular calcium in human atrial myocytes.
Therefore , this study aimed to characterize aortic hemodynamics in relationship to WMH in postmenopausal women.
Therefore , this study aims to investigate the association between frequency of breakfast consumption and muscle strength among apparently healthy Japanese adults.
Therefore , this study aims to investigate the concept of health care-related perceived control from the viewpoint of frail older adults.
Therefore , this study investigates the determinants of life satisfaction among the oldest-old ( i.e. individuals aged @number@ or over ) in China.
Therefore this study provides new evidence for a correlation between neocortical Aβ accumulation and basal forebrain degeneration.
Therefore , this study sought to determine the contribution of NO in the PLM-induced LBF with age.
Therefore , this study was designed to investigate this issue.
Therefore , this test allows us to accurately identify prostate cancer patients likely to experience future recurrent disease immediately following removal of the primary tumor.
Therefore , this work was aimed to the study of age-related changes in the number of blood vessels in the human dermis.
Therefore , thorough and precise knowledge of the corticospinal tract is necessary for successful brain rehabilitation.
Therefore , thorough research is still needed in this dynamic and promising field.
Therefore , tissue-specific gene expression may protect against common age-dependent methylation.
Therefore , TLRs are worthy of investigation to elucidate their roles in chronoinflammaging associated AD.
Therefore , to increase the predictive value ( PV ) of GRS it is necessary to first see whether the included polymorphisms have heterogeneous effects.
Therefore , transcatheter aortic valve implantation has emerged as a promising technology for treating this group of high risk patients.
Therefore , transcriptionally active SNPs near these genes may serve as putative susceptibility alleles.
Therefore , treatment data for men is still rather limited , and there is also very little information in the oldest subset of this population.
Therefore , treatment for COPD needs to focus on these comorbidities as well as the lungs.
Therefore , treatment of AF can be challenging in some patients.
Therefore , treatment recommendations may need to be individualized and adapted to co-morbidities.
Therefore , TRF length is associated with kidney function and may serve as a marker of aging.
Therefore , uncovering regulators of the antioxidant stress responses is important for understanding the course of these diseases.
Therefore , understanding how cells respond to DNA damage has become one of the most intense areas of biomedical research in the recent years.
Therefore , understanding how stress during childhood shapes and rewires the brain may optimize preventive and therapeutic strategies for these disorders.
Therefore , understanding how this mutant form of lamin A provokes HGPS may shed significant insight into physiological aging.
Therefore , understanding nongenomic aldosterone / MR effects is of potential relevance for modulating genomic aldosterone effects and may provide additional targets for intervention.
Therefore , understanding the impact of aging on bimanual coordination is essential for prolonging functional independence and well-being in older adults.
Therefore , understanding these hemostatic changes could contribute to developing strategies for the proper management of health in old age.
Therefore , unnecessary driving restrictions need to be avoided.
Therefore up-to-date recommendations for optimal administration of blood products in hemotherapy are needed.
Therefore , up to six treatments were possible with any visit.
Therefore , urgent needs must be met in order to help policy-makers deal with the increasing societal costs of diseases.
Therefore , use of age-specific norm is recommended.
Therefore , using simple tool for evaluation of diet of older population in relation to overweight and obesity is of public health importance.
Therefore , usNLC-CoQ10 are very suitable to increase the antioxidant potential of skin.
Therefore , vaccines may predispose vaccinees to the risk of developing DHF in future infections.
Therefore , vascular risk reduction is important in both age groups.
Therefore , veteran tennis player side asymmetries were examined to investigate age , sex and starting age effects on bone exercise benefits.
Therefore , VGs could be added as an adjunct treatment in rehabilitation for various pathologies to stimulate patient motivation.
Therefore , VZV-specific CD4 ( + ) T cells in the skin of older individuals are functionally competent.
Therefore , walking capacity may serve as an early risk marker.
Therefore , WBVT could be undertaken to minimise age-related performance deterioration in middle-aged female populations.
Therefore , WBVT does not appear to acutely improve balance in CAI.
Therefore , we aimed to characterize the genome-wide methylation and gene expression signatures and the differentiation capacity of hMSCs from patients with hip fractures.
Therefore , we aimed to determine the efficacy of this trunk orthosis during level walking in healthy elderly subjects.
Therefore , we aimed to evaluate associations among frailty , visceral fat depots and PA in patients with symptomatic severe AS.
Therefore , we aimed to examine whether the clinical condition of COPD patients is reflected in plasma klotho concentration.
Therefore , we aimed to identify predictors of previously unknown AF during in-hospital ECG monitoring.
Therefore , we aimed to investigate the role of marital status in the association between BZD use and injurious RTCs among senior drivers.
Therefore , we aim to examine the association between genetic variants in promoter of ATM and longevity in Chinese Nonagenarians / Centenarians.
Therefore , we applied a cross-sectional approach for investigating the relationship between muscular strength and the condition of the intrarenal vasculature.
Therefore , wear studies addressing LTD of Y-TZP are needed utilizing accelerated aging.
Therefore , we asked if activation of astrocytic CEBPD could contribute to AD pathogenesis.
Therefore , we assessed the associations between air pollution , circulating immune mediators and impaired glucose metabolism.
Therefore , we compared morphology and function of skeletal muscles between different age groups.
Therefore , we compared Trec and Tint during a half-marathon during which cold water was ingested to prevent bodyweight ( BW ) losses > 2%.
Therefore , we compare the likely consequences of innate immune cell interactions with T cells in young versus elderly hosts.
Therefore , we conclude that HIT is superior to MCT for enhancing aerobic fitness.
Therefore , we conclude that OXM is neuroprotective against ischemic brain injury.
Therefore , we conclude that the IPL-ALA-PDT protocol requires optimization for photorejuvenation in Asians.
Therefore , we conducted a cross-sectional study in a representative urban area of Beijing , China.
Therefore , we conducted a meta-analysis to evaluate the association between these two polymorphisms and hepatitis virus-related HCC risk.
Therefore , we conducted a prospective study to identify predictors of insulin-associated weight gain.
Therefore , we conducted a retrospective cohort study to examine the relationship between TSH elevation and all-cause mortality in elderly patients with CKD.
Therefore , we conducted a retrospective examination of naming latencies from a randomized picture naming task containing a wide variety of items and categories.
Therefore , we conducted a systematic review of previous studies that have focused on the association between TB death and socio-economic factors.
Therefore , we conducted a systematic review to address these issues.
Therefore , we conducted a theory-led , systematic review of how intra-organizational dynamics among hospital managers and physicians can influence entrepreneurship.
Therefore , we conducted Experiment @number@ in which we collected several task and resting-state fMRI runs with an acquisition order counter-balanced.
Therefore , we confirmed the content validity of the proposed ULCEAT method.
Therefore , we decided to review the assessment methods and search for tests that evaluate analogous cognitive processes in animals and humans.
Therefore , we designed and synthesized 8-halogenated 7-deaza-2'-deoxyguanosine triphosphate ( 8-halo-7-deaza-dGTP ) derivatives as mimics of 8-oxo-dGTP in order to interact with hMTH1.
Therefore , we determined the proportion of US Caucasians recommended for treatment of osteoporosis according to NOF Guidelines ( @number@ and @number@ ) .
Therefore , we developed a comparative study based population which contains @number@ longevity and @number@ control.
Therefore , we developed a method to calculate senescence rates from the acceleration of mortality directly without modeling the mortality rates.
Therefore , we developed and evaluated a novel 2-step approach to delirium surveillance for the ED.
Therefore , we developed a survey adaptation of the MoCA , called the MoCA-SA , and describe its psychometric properties in a large national survey.
Therefore , we evaluated resident exposure and participation in treatments as well as proposed management for SRMs.
Therefore , we evaluated the agreement in an elderly population with high risk of arterial stiffness.
Therefore , we evaluated the measurement invariance of the SWFL scale across older adults from Chile and Ecuador.
Therefore we evaluated the relation between both circulating and induced inflammatory markers and serum thyroid function parameters in the Leiden 85-plus Study.
Therefore , we evaluated whether exposure to phthalates affects IR , and oxidative stress is involved in the phthalates-IR pathway.
Therefore , we examined oenothein B responsiveness in T cells from cord blood , young , and adult donors.
Therefore , we examined the association between VASH1 expression in the tumour and clinical outcomes.
Therefore , we examined the association of protein and amino acid intakes with frailty among elderly Japanese women.
Therefore , we examined the clinicopathological and molecular features of these tumors in elderly patients.
Therefore , we examined the relationship between subjective sleep quality and objective sleep characteristics ( standard PSG and qEEG ) across middle to older adulthood.
Therefore , we examine whether higher WMH burden is related to worse cognitive function in older adults with BD.
Therefore , we explored whether Nrf2 is involved in the mechanism by which rapamycin delays cell senescence.
Therefore we failed to support the suggestion that advanced age of the DS grandmother is responsible for meiotic disturbance in her daughter.
Therefore , we found preliminary evidence that mirror-neuron resonance is not shaped by physical similarity but by the kinematics of the observed action.
Therefore , we generated CUGBP1 KO mice and examined HBL signatures in the liver of these mice.
Therefore , we have characterized developmental changes in peripheral B cell populations from infancy to adulthood in order to define age-dependent reference values.
Therefore , we have demonstrated that age affects the ability to recover balance nearly a decade earlier than the rate of falls.
Therefore , we have evaluated the role of miR-216a as a molecular component involved in the loss of autophagic function during endothelial aging.
Therefore , we have here further established critical components for decreased AID with age.
Therefore , we have hypothesized that BET might be effective on osteoblast cell differentiation.
Therefore we hypothesized that a common variation in the SLC6A4 is associated with inter-individual variation in CPM.
Therefore , we hypothesized that APC protects against MGO-induced cardiomyocyte apoptosis through the inhibition of ER stress.
Therefore , we hypothesized that individuals with a familial predisposition for longevity have a higher amplitude circadian serum cholesterol concentration rhythm.
Therefore , we hypothesized that mechanisms of vacuolar formation in RVs and GVD bodies are common despite their role in two differing pathologies.
Therefore , we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting ( CABG ) surgery are associated with stroke.
Therefore , we hypothesized that NLRP3 inflammasome activation promotes adipogenesis and repress osteogenesis in MSCs via inhibiting SIRT1 expression.
Therefore , we hypothesized that ob / ob mice have abnormalities in hair cycle progression beyond @number@ weeks of age.
Therefore , we hypothesized that the ApoE-ε4 allele is associated with altered patterns of longitudinal ventricular expansion , in dementia and normal aging.
Therefore , we hypothesized that TNF-α induces JNK-dependent epithelial plasticity , which contributes to lung matrix remodeling.
Therefore , we hypothesize that the key steps leading to synaptotoxicity by Aβ and gramicidin involve peptide aggregation , pore formation , and calcium dysregulation.
Therefore , we investigated age-related association on the presence of mtDNA heteroplasmy within the hypervariable segment @number@ ( HVS-I ) in a selected study group.
Therefore , we investigated age-related methylation changes in semen-specific tDMRs using body fluids from young and elderly men.
Therefore , we investigated FF HDL particle components as predictors of embryo quality during IVF.
Therefore , we investigated in rats whether Japanese food is beneficial to health maintenance compared with American food.
Therefore , we investigated the appropriate concentration of EACA for neonates undergoing bypass.
Therefore , we investigated the association of type @number@ diabetes with cognitive function in people aged 35-82 years.
Therefore , we investigated the changes of APE in aging rat kidney since aging is the consequence of increased susceptibility to apoptosis and impaired repair.
Therefore , we investigated the effectiveness and tolerability of Korean Red Ginseng adjuvant treatment in patients with residual symptoms of major depression.
Therefore , we investigated the effect of alfacalcidol on muscle mass in patients with low muscle mass.
Therefore , we investigated the effects of anthocyanins from fruits of Vitis coignetiae Pulliat ( AIMs ) on EGF-induced EMT and the underlying molecular mechanisms.
Therefore , we investigated the effects of vegetable peptones on cell proliferation and type I collagen production and their possible mechanisms in human dermal fibroblasts.
Therefore , we investigated the impact of testosterone deprivation on mitochondrial gene expression in the brain of male gonadectomized ( GDX ) rats.
Therefore , we investigated the relationship between self-reported knee pain and the consumption of fruits vegetables , carotenoids and vitamin C and self-reported knee pain.
Therefore , we investigated the suppressive function of RORα on the proliferation of vSMCs and the molecular mechanisms involved.
Therefore , we investigated this relationship in industry workers , whose health has economic implications.
Therefore , we investigated whether components of metabolic syndrome are associated with type @number@ diabetes mellitus in elderly.
Therefore we investigated whether foot pain , foot structure , and / or foot function is affected by obesity in older adults.
Therefore , we investigated WM morphometric changes using FD analyses in ALS patients with different clinical phenotypes.
Therefore , we investigate whether age differences between couples affect extent of depressive symptoms among older adults.
Therefore , we looked for a circulating regulator.
Therefore , we measured the spinal canal diameter and vertebral body height at T5 , T6 , L4 , and L5 with age.
Therefore , we obtained a higher number of early stages in the MIS group ( p < @number@ ) .
Therefore , we performed a meta-analysis on randomised trials comparing different DAPT durations.
Therefore , we performed an autologous bone marrow cells to modulate the immune system with his permission.
Therefore we performed lipid profiling of keratinocytes which demonstrated a major dysregulation of cellular lipid metabolism.
Therefore , we performed longitudinal clinical evaluation and retrospective chart review of autopsied patients diagnosed with isolated LMN disease.
Therefore , we propose that functional peptides can be transferred to the skin by dietary supplements of collagen.
Therefore , we propose that NaDC3 accelerates cellular aging by inhibiting SIRT1.
Therefore , we propose that these new formulas , with their improved accuracy , be used in healthy active and clinical populations.
Therefore , we propose that to date , the strongest pro-tumoural action of BASIGIN is mediated through the control of fermentative glycolysis.
Therefore , we reviewed the safety of codeine in adults.
Therefore , we sequenced OPTN in @number@ FTLD cases but no mutations were detected , suggesting changes in OPTN do not cause FTLD.
Therefore , we set out to evaluate and compare plasma leptin and adiponectin levels in Danish and Inuit children.
Therefore , we shall have to think about new ways in which our societies can reaffirm basic human values.
Therefore , we should focus on the drug discovery for targeting the tumor microenvironment to develop tumor-specific cytostatic agents including angiogenesis inhibitors.
Therefore , we should pay more attention to post implantation infection in the elderly.
Therefore , we sought to examine the relationship between age and 24-hour urine composition.
Therefore , we sought to examine the role of KCNJ6 polymorphisms in adult alcohol dependence and stress-related alcohol abuse in adolescents.
Therefore , we sought to explore the mechanisms underlying these phenomena.
Therefore , we sought to systematically review and determine the effect of ExT on RBCV in healthy individuals across all ages.
Therefore , we sought to understand and compare the associations of ageing and obesity with SHBG.
Therefore , we studied a 13-item version of PSS and 10-item and 4-item subsets representing PSS-10 and PSS-4.
Therefore , we studied the impact of 24-week dietary protein supplementation on cognitive performance in pre-frail and frail elderly people.
Therefore , we suggest ARE as a potential candidate for developing anti-cancer drugs.
Therefore , we suggest that PLE can be a potential agent for prevention of skin aging.
Therefore , we tested the hypothesis that a B-lymphocyte response to stroke could contribute to the onset of dementia.
Therefore , we tested the hypothesis that ATP-mediated vasodilatation is impaired with age in healthy humans.
Therefore , we tested the hypothesis that neutrophils constitute the predominant selection pressure in vivo.
Therefore , we tried a new combination therapy of intradermal RF and HA filler.
Therefore , we used a Chinese community-dwelling cohort to examine these relationships.
Therefore , we used PC3 cells for further studies.
Therefore , we wanted to elucidate whether a physical interaction exists between Trx-1 and actin and what the functional consequences are.
Therefore , we will probably have to re-define the current risk threshold for many factors , molecules and stresses.
Therefore what is needed at this time are international nursing partnerships and assistance.
Therefore , what we eat , or refrain from eating , may have an important impact on our cognitive ability and mental performance.
Therefore , when there is an oxidant / anti-oxidant imbalance , no matter what direction , cells are likely to be damaged.
Therefore , whether a biomaterial strongly influences cellular aging process must be considered in the selection of a biomaterial for the biomedical application.
Therefore , with an increasing elderly population , interventions that can improve muscle mass content and / or function are essential.
Therefore , with increased attentional demands healthy OA employed different compensatory strategies than YA to maintain postural control.
The reform processes are positioned within the wider context of European integration and public administration reforms.
The refractive development of the pseudophakic eyes was not significantly different from the fellow phakic eyes.
The refractive errors were classified by the spherical equivalent ( SE ) : sphere + ½ cylinder.
The refractive index of the lens is largely dependent on high concentrations of soluble proteins called crystallins.
The refractory diabetic wound is the result of various endogenous and exogenous factors.
The regeneration of human tissues requires actively dividing tissue-specific stem cells.
The regeneration potential of DSCs declines with advanced age ; however , the mechanism of the impaired potential in DSCs has not been fully explored.
The regenerative capacity of stem cells harvested from elderly people is however controversial.
The regenerative decline of organisms during ageing is linked to the reduced proliferative activity , impaired function and exhaustion of tissue-specific stem and progenitor cells.
The regenerative potential declines upon aging.
The regimen produced an average of \ "marked improvement \ " in melasma severity ( 51-75% improvement ) .
The regional PiB uptake values and SVD markers were obtained and compared between groups.
The regional relationship between ChaCo , glucose uptake and Aß was explored via linear regression.
The regional responses may be understood in terms of a tentative model of the bladder control system.
The region-based association signal of ITGB3 replicates in an independent data set and achieves formally genome-wide significance.
The region is typically discussed as having a unitary function because of a common pattern of relative deactivation observed during attentionally demanding tasks.
The Région Languedoc Roussillon is the umbrella organisation for an interconnected and integrated project on active and healthy ageing ( AHA ) .
The region of JDP2 that encompasses its histone-binding domain and DNA-binding region is essential to inhibit histone acetylation by histone acetyltransferases.
The regions with a significant GWR decline with age surround the ventricular system.
The region treated was also found to be a significant predictive factor.
The registered parameters were stamina , posture , and pain.
The register was made by @number@ patients of elderly and senile age with coronary heart disease being on treatment during the period since 2013-2014.
The registration numbers of the trials reported are NCT00276848 and NCT00262795.
The registry also provides the government and health care politicians with data for setting aims for elderly care.
The registry helps the caregivers fulfill the preventive care according to the best available clinical knowledge and practice.
The registry is used in @percent@ of the municipalities and county councils throughout the country.
The regression analysis demonstrated that the only chronologic age was associated with the facial growth.
The regression analysis performed showed that the sedentary habit predicts the %fat mass and CMJ performance.
The regression analysis results further indicated that only MP and the STS stabilization phase could differentiate individuals who had past fall events.
The regression equation of CIMT vs. age for all four groups is determinated.
The regression line between the two values was y = @number@.097x + @number@ where x = estimated value , y = measured value.
The regression model was significant , explaining @percent@ of the variance in PA ( F = @number@ P < @number@ ) .
The regression model was significant , where the ABC score predicted falls at @number@ months.
The regression model was used to examine the influence of elderly women's participation in productive activities on their life satisfaction.
The regression model , which included all eight variables , explained @percent@ of the variance associated with LOS ( r = @number@ ) .
The regression of lung function to height largely follows the ECCS prescriptions.
The regression of the individual morphologically normal cell profiles.
The regression result indicated that predisposing , enabling and community factors were significantly associated with the aging care model preference.
The regucalcin gene is localized on the X chromosome and its expression is enhanced through various transcription factors.
The regularity in FW was significantly lower among older volunteers.
The regular smoking rate was @percent@ ( @number@ ) .
The regulation of PUMA during Aβ-induced neuronal apoptosis remains poorly understood.
The regulatory mechanisms of oncogenic activity of EWS fusions could provide new prognostic biomarkers , therapeutic opportunities and tumor-specific anticancer agents against ESFTs.
The regulatory mechanisms underlying these functional abnormalities remain to be uncovered.
The regulatory processes that shape the platelet transcriptome and the full scope of platelet translation have remained elusive.
The regulatory process places a significant importance on Japanese data collection regardless of data accumulation from other countries.
The regulatory role of ERβ is due in part to ERβ acting as a negative regulator of ERα-mediated transcription.
The REGγ-proteasome serves as a short-cut for the destruction of certain intact mammalian proteins in the absence of ubiquitin- and ATP.
The rehabilitation was carried out with the standard rehabilitation protocol.
There has been a change in this research arena , necessitating a re-evaluation of our knowledge on the topic from a multidisciplinary perspective.
There has been a growing appreciation for the differences in epidemiology across age groups and the potential differences in disease biology.
There has been a lack of research into all aspects of this dysfunction , and as yet , no effective treatments exist.
There has been a large growth in the variety of treatment options in recent years.
There has been an explosion in our knowledge of the pathways and mechanisms by which the immune system can influence the brain and behavior.
There has been a rapid increase in the number of elderly patients worldwide.
There has been a recent attempt to define the age-associated changes predisposing individuals to develop IPF.
There has been a recent focus on the development of preclinical models of frailty in mice.
There has been a significant escalation in the incidence of this malignancy in the Czech Republic and in developed countries of Europe recently.
There has been a striking decrease in the prevalence of H. pylori infection , especially in younger Japanese populations.
There has been a substantial research on the underlying factors responsible for aging both in the general and the HIV-infected populations.
There has been considerable interest in a stimulus ( \ "the dress \ " ) that yields starkly divergent subjective color percepts between observers.
There has been considerable interest in peroxisome proliferator-activated receptors ( PPAR ) in the kidney , which affect multiple processes in addition to mitochondrial biogenesis.
There has been controversy as to whether there is an underlying neurodegenerative process of the cerebellum in essential tremor ( ET ) .
There has been controversy over the past three decades about whether this slowing is generalized or process-specific.
There has been enormous growth in participation at Masters events , and older athletes have been competing at the highest levels with much younger athletes.
There has been growing concern about racial and ethnic disparities in completion rates of advance directives ( ADs ) in community-dwelling older populations.
There has been limited research examining the risks , benefits , and use of common endoscopic procedures in the elderly.
There has been limited research in people attending memory clinics.
There has been limited work on health visualizations from a consumer perspective , in particular for an older adult population.
There has been little change in long-term case-fatality , despite changes in practice.
There has been little research on the effects of aging on mortality rates and causes of death in this group.
There has been minimal attention paid in the literature to the aesthetics of the perioral area , either in youth or in senescence.
There has been much research both experimental and clinical on this topic.
There has been no prospective study on age-related changes of the extensor muscles of the cervical spine in healthy subjects.
There has been significant controversy around describing , defining and characterizing mild cognitive impairment.
There has been some debate as to why the start-off age for exemption among the elderly is @number@ years.
There has not been an update on the underlying nature and etiology of late-life migraine accompanimentsd since the original description.
There has not yet been an equivalent discussion for MEG developmental studies.
There has recently been an increased demand in bone age estimation ( BAE ) of living individuals and human remains in legal medicine applications.
There have been a few descriptive studies in aged rodents about transcriptome changes in the hippocampus , most of them in males.
There have been analyzed the WHO conception on active aging , which has no precise universally agreed definition , its main determinants.
There have been a number of studies attempting to ameliorate this through memory interventions including memory rehabilitation and training.
There have been considerable advances in understanding the biology of many age-related disorders that cause dementia.
There have been exciting recent advances in the detection of somatic mosaicism.
There have been extensive studies on the roles of DNA methylation in cancers , and several cancer drugs were developed targeting this process.
There have been few case reports on the cytopathologic features of MASC to date.
There have been few discussions about which the format is most effective.
There have been few investigations of the link between changes in life-course socioeconomic position ( SEP ) and cognitive decline or incidence of dementia.
There have been few replications of efficacious evidence-based programs for dementia caregivers offered in community settings.
There have been few reports on the development of metabolic disorders , especially when they are considered as a cluster.
There have been few studies on the process of ageing of the brain in chronic neurological disorders.
There have been important advances in both preventive vaccines and in cure research , but both areas require ongoing investment and innovation.
There have been inconsistencies throughout the literature in defining disability and aging.
There have been increasing numbers of scientific reports on the therapeutic effect of ASCs on skin repair , scar remodeling and rejuvenation.
There have been increasing reports of noncognitive symptoms , including loss of motor function , reported to be associated with incident AD.
There have been major advances in our understanding of the principles of brain plasticity and behavior in laboratory animals and humans.
There have been multiple attempts to measure frailty , some focusing on physiologic losses , others on specific diseases , disabilities or health deficits.
There have been no curative treatments for CAA so far.
There have been no national studies in Ireland on the factors that affect early withdrawal from the labour force through disability or long-term illness.
There have been no RCTs with the prespecified outcomes of cardiovascular events or mortality.
There have been no relevant reports about ASP's effect in regulating the aging of leukemia cells.
There have been relatively few placebo-controlled studies of amitriptyline in migraine prophylaxis or in treatment of chronic daily headache ( CDH ) .
There have been several modifications along the phylogenetic tree as NF-κB has taken a larger role in managing cellular stresses.
There have been showed satisfaction of quality of life depending on getting care in different care system's organizations.
There have been some cross-sectional studies of anemia and frailty but no longitudinal studies.
There have been some studies investigating the effect of WBV on osteoporosis ; however , the intervention models and results are different.
There have been substantial changes in the clinical and demographic characteristics of HIV-positive patients receiving ART in Asia.
There have , however , been few studies investigating the role of cognitively stimulating leisure activities in maintaining cognitive health.
There have no universally accepted criteria and have been established for classification of underactive bladder ( UAB ) at present.
The reimagining article examines how to diminish the role of nursing homes in the LTC system.
The reinforcing properties of alcohol are mediated by dopaminergic signaling ; however , there is little evidence to indicate how stress alters alcohol reinforcement.
Therein , senescent and damaged CAFs , as well as non-tumoral stellate cells , expressing SASP including IL- @date@ contribute to the development of SH-HCC.
There is a basic distinction between congenital and acquired cataracts.
There is a broad consensus on the coupling of deteriorating gait and vestibular asymmetry , which has proved predictive of falls in the elderly.
There is a broad scientific consensus that amyotrophic lateral sclerosis ( ALS ) , a fatal neuromuscular disease , is caused by gene environment interactions.
There is a broad variety of filler materials and products.
There is accumulating evidence for an interaction between stress and a serotonin transporter polymorphism , though there is also heterogeneity among studies.
There is accumulating evidence suggesting that children may drive the spread of influenza epidemics.
There is accumulating evidence that altered chromatin plasticity and histone acetylation are also involved in cognitive aging , neurodegeneration , and neuropsychiatric diseases.
There is accumulating evidence that neurotrophins , like brain-derived neurotrophic factor ( BDNF ) , may impact aging and Alzheimer's Disease.
There is accumulating scientific evidence that air pollution plays an important role in extrinsic aging.
There is a clear need for a clinical assessment tool to detect such a decline in newly diagnosed patients.
There is a compelling need to assess the efficacy of assessment and management of modifiable fall risk factors in patients with advanced cancer.
There is a connection between caloric reduction and melatonin levels in GIT.
There is a critical need to potentially individualize new strategies able to prevent and to slow down the progression of predementia and dementia syndromes.
There is a dearth of health economic data in the area of behavioural interventions for dementia prevention.
There is a dearth of research focused on factors related to the development of regular tanning.
There is a dearth of research on the neuroendocrine control of eating after menopause.
There is a decline in pregnolone secretion and C-19 steroids ( DHEA ) with aging.
There is a definite need to acquire knowledge about harmful effects of occupational noise to support the prevention of NIHL and ensure healthier workplaces.
There is a demand for effective training methods that encourage exercise adherence during advancing age , particularly in sedentary populations.
There is adequate evidence that the main aims of phases @number@ ( rationale for use ) and @number@ ( discriminative ability ) have been achieved.
There is a difference value score \ "Small assessment of nutrition \ " between the two groups ( p = @number@ ) .
There is a direct relationship between aging and increased incidence of inflammatory diseases.
There is a discrepancy between theoretical stroke knowledge and illness perception.
There is a fairly consistent , albeit non-universal body of research documenting cognitive declines after cancer and its treatments.
There is a gap between what research evidence shows is beneficial to caregivers and what is actually provided.
There is a good inter- and intra-observer reliability of our CT scan-based coracoid process bone mineral density measurement rendering it reproducible in daily clinical practice.
There is agreement about the definition of response as a reduction in headache days by @percent@ to @percent@.
There is a growing awareness of the need for improved treatment and care of older adults with epilepsy.
There is a growing body of evidence that CNS resident as well as peripheral immune cells participate in regulating hippocampal adult neurogenesis.
There is a growing body of evidence that WRN accomplishes its task in close connection with the replication checkpoint.
There is a growing body of research and interest in the relationship between diet and cognitive function.
There is a growing body of research on the modifiability of executive functions in different stages of life.
There is a growing call for civic engagement , largely in the form of formal volunteering , among older adults in America.
There is a growing emphasis on examining preclinical levels of Alzheimer's disease ( AD ) -related pathology in the absence of cognitive impairment.
There is a growing interest in the potential of virtual reality-based interventions for balance training in older adults.
There is a growing interest in the role of vitamin K in health , especially in aging populations.
There is a growing interest in understanding more clearly the mechanisms regulating activation and suppression of miRNAs expression in benefit of health prevention advancement.
There is a growing literature regarding the extra-pulmonary manifestations of COPD , which can have a significant impact on symptom burden and disease progression.
There is a growing need to examine the effects of these factors on normal cognitive aging.
There is a growing recognition of sex differences in Alzheimer's disease ( AD ) .
There is a high demand for facial aesthetic enhancement , and the periorbital region is one of the first areas to show signs of aging.
There is a high mortality rate in patients admitted to hospitals acutely from care homes.
There is a high motivation to their rehabilitation.
There is a high potential for DDIs between DAAs and comedication / cART.
There is a lack of consensus regarding the definition of malnutrition and how it should be assessed.
There is a lack of papers about cosmetic effects and patients ' preferences.
There is a large group of people taking melatonin daily who believe that melatonin is the \ "fountain of youth \ ".
There is a large ongoing multicentric randomized clinical trial sponsored by NIH for testosterone control in old men with low testosterone levels.
There is a larger proportion and number of older adults in the labor force than ever before.
There is a linear relationship between AMH and oocyte yield after ovarian stimulation , which is of value in predicting ovarian hyperstimulation.
There is almost always a time to call it quits for everything.
There is a longitudinal clinic component and a research project requirement.
There is a long-standing skepticism that the concept of fitness can be applied on a communal level , and of group selection in general.
There is also a growing understanding that environmental factors are likely to contribute to the etiology of ET.
There is also a need for better treatment of people diagnosed with chronic kidney damage.
There is also an emerging consensus on what the next investigative steps should be.
There is also a process evaluation based on Dobbins analyses that analyse in particular the potentials for change in clinical practice of change agents.
There is also a reduction in anti-ageing molecules , such as sirtuins and Klotho , which further accelerates the ageing process.
There is also a reduction in antiaging molecules , such as sirtuins and Klotho , which further accelerate the aging process.
There is also a significant association between the folding energy of an mtDNA region and the number of breakpoints that it harbours.
There is also compelling evidence that supplemental vitamin D is an effective therapeutic option for falls prevention.
There is also considerable variability in deadlines across countries , as well as within them.
There is also evidence that behavioral disturbance due to pain is misattributed to psychiatric conditions and consequently frequently treated with psychotropic rather than analgesic medication.
There is also evidence that healthcare providers ' attitudes towards vaccination are among the most important influences on the decision to vaccinate.
There is also evidence that positivity effects may be restricted to stimuli with low relevance in old age.
There is also evidence that vibration therapy is useful in treating sarcopenia , which confounds skeletal fragility and fall risk in aging.
There is also increasing information about the PCOS phenotype after menopause.
There is also increasing interest in understanding its possible role in the development of intracerebral hemorrhage , Alzheimer's disease ( AD ) and vascular dementia.
There is also increasing realization that a continuum between health and disease often exists without strict boundaries.
There is also need to evaluate long-term effects and cost-effectiveness.
There is also no comparative study for active and passive falls.
There is also the emergence of reference values and beneficial elements of regression by treatment.
There is also uncertainty about how improvement in sarcopenia should be measured in pharmaceutical trials.
There is always a relationship between stress ( the stimulus ) and coping ( the response ) .
There is a moderate heritability of EE , which is independent of the heritability of FFM.
There is a more complex rise during childhood and adolescence , which is likely to be more reflective of different stages of follicle development.
There is ample evidence from studies of both unicellular and multicellular organisms that helicase-inactivating mutations lead to cellular dysfunction and disease phenotypes.
There is ample evidence that protocol-driven multidisciplinary stroke unit care within a hospital improves recovery from stroke.
There is ample evidence to indicate vascular risk factors are also linked to neurodegenerative processes preceding cognitive decline and dementia.
There is an associated progression in atrophy of these muscles , which may be important in fall-related hip fractures.
There is an early slowing of LV relaxation and diastolic suction beginning in early middle age , with the greatest reduction observed in seniors.
There is a need for a multifactorial strategy that acts on different determinants in order to stimulate PA in LTCF.
There is a need for an easy-to-use , freely available programme that can run simple and choice reaction time tasks with no special software.
There is a need for animal models that reflect the increases in pro-inflammatory cytokines and oxidative damage observed during aging in humans.
There is a need for an objective and quantitative method for determining the status of a wound without removing the wound dressings.
There is a need for a worldwide standardization of these methods to avoid misunderstanding and confusion among sunscreen users.
There is a need for better communication with older women experiencing OAB symptoms about the physiology of the condition.
There is a need for bioengineered therapies to improve the overall health of the growing and aging world population.
There is a need for biomarkers for accurate and timely diagnosis , effective treatments , and services to reduce this socioeconomic burden.
There is a need for brief dementia screening instruments that can accurately diagnose dementia in primary care settings.
There is a need for further studies on age-related changes in pain perception.
There is a need for improving the use of EBP , particularly among registered nurses and occupational therapists.
There is a need for independent studies comparing the efficacy and risk of side effects of NOAC with that of VKA in elderly AF patients.
There is a need for laboratory tests giving a reliable estimate of the androgen sensitivity of each subject.
There is a need for more rigorous research on methodological issues and the efficacy of recruitment methods.
There is a need for more robust clinical trials evaluating the efficacy of using video game systems as an adjunct to conventional rehabilitation.
There is a need for prospective , controlled studies investigating safety , efficacy and persistency of hyaluronic acid fillers in this area of the face.
There is a need for publications of ReGS in general medical journals.
There is a need for simple and quickly identified screening tools to identify those older adults whose driving should be reviewed.
There is a need for specific multi-institutional trials to better understanding of clinicopathologic features and establishment of optimal therapy for this disease.
There is a need to develop credible infrastructures of support that enable people with dementia to participate in research.
There is a need to develop ( national ) dementia plans on a societal level to implement strategies to combat these challenges.
There is a need to develop novel preventive approaches for this malignancy.
There is a need to educate on the proper use and interpretation of assessment tools in order to improve care.
There is a need to ensure that older people are given appropriate advice about keeping physically active and eating sensibly.
There is a need to further determine the predictive values of these cut-off points on outcomes through longitudinal study design.
There is a need to further facilitate the identification of persons at elevated risk in routine practice.
There is a need to improve awareness , treatment and especially control of hypertension among elderly Singaporeans.
There is a need to improve health care systems for the prevention and management of chronic diseases.
There is a need to integrate seniors with younger generations in order to eliminate the stereotypes prevailing in society about older people.
There is a need to obtain a consensus on definition of the technologies , and also to revisit work strategies and develop innovative business models.
There is a need to recreate the anabolic effects of loading on the musculoskeletal system , especially in frail individuals who cannot exercise.
There is a need to synthesize the highest-quality falls prevention evidence in one place for clinicians.
There is a need to update this evidence given the changing nature of sedentary behaviour and continued interest in this field.
There is a need to use age-specific reference values for the adequate interpretation of 2DSTE measurements.
There is a negative correlation between anxious and cognitive complaints measured at baseline , and successful ageing indicators @number@ years later.
There is an emerging need to understand determinants of cardiovascular disease ( CVD ) among individuals aging with HIV in sub-Saharan Africa.
There is an emphasis on early screening , as it is believed that early detection will allow early intervention.
There is an evidence gap to ensuring safe / effective use of medicines in older adults.
There is an evidence that the release of carnosine from the skeletal muscle sarcomeres moieties during physical exercise affects autonomic neurotransmission and physiological functions.
There is a new criterion for the morphology of LM that applies only to computerized LM detection to better match expert visual detection.
There is an extensive cross-talk between inflammation and coagulation in stenotic valve tissue which contributes to the calcification and mineralisation of the aortic valve leaflets.
There is an important association between the prevalence of diabetes and the number of patients on RRT.
There is an increased frequency of dysthyroidism in elderly people.
There is an increased incidence of autoimmune thyroid disease ( AITD ) in women with infertility.
There is an increase of AP patients with ages @number@ to @number@ years and older than @number@ years.
There is an increasing and coherent body of evidence that implicates aluminum as being one such significant factor.
There is an increasing awareness that posterior atrophy ( PA ) is important in AD and may aid the differentiation of AD from FTLD.
There is an increasing body of neuroimaging literature discussing issues related to testing children in developmental studies ( Crone et al.
There is an increasing focus on the role of T cells during ageing because of their impact on the overall immune responses.
There is an increasing recognition that central aortic pressure is more relevant than brachial measure for the prediction and pathophysiology of cardiovascular disease.
There is an intense debate whether low testosterone contributes to ill-health as opposed to being a biomarker for its presence.
There is an intriguing dichotomy in relation to pro-oxidant property.
There is an obvious decrease in LDH in the elderly female.
There is an obvious regional longevity phenomenon in China and many longevity counties are located in South China.
There is an ongoing discussion on how to diagnose a hyperechogenic pancreas and what is the clinical significance of diffusely hyperechogenic pancreas.
There is a nonmonotonic dose response curve for E2 influences on behavior and transcription.
There is an opportunity to develop new approaches to integrated care for older people in prevention and provision of community alternatives to hospital care.
There is an undeniable concern among the elderly about the mental changes they experience as they grow older.
There is an unmet need for a parenteral influenza antiviral therapy to treat hospitalized patients.
There is an unmet need for epidemiologic and molecular pathologic approaches to address the issue of inflammation and prostate cancer.
There is an unprecedented acceptance of rhytidectomy by today's society.
There is an urgency to incorporate the concept of cardiovascular aging as a disease into clinical medicine.
There is an urgent need for expanding the number of brain banks serving psychiatric research.
There is an urgent need for intervention trials to test strategies to reduce inappropriate drug use and its associated adverse health outcomes.
There is an urgent need for policy frameworks to support and supplement inputs from families.
There is an urgent need for supports to increase people's activity post-TJR in order to facilitate enhancement of post-surgery levels of engagement.
There is an urgent need to develop more effective therapies for chronic obstructive pulmonary disease ( COPD ) that target the underlying inflammatory disease process.
There is an urgent need to develop novel objective measures of physical functioning in this patient group to encourage evidence-based clinical care.
There is an urgent need to develop reliable biomarkers of exposure , surrogate endpoints , as well as susceptibility for GI.
There is an urgent need to explore models of care that address the complex health needs of older adults with OUD.
There is an urgent need to identify innovative upstream solutions to barriers experienced by older adults in accessing and buying healthy food.
There is an urgent need to translate science into practice and help enhance the capacity of professionals to deliver evidence-based programming.
There is a particular interest in safe and effective ways to decrease skin laxity and smooth irregular body contours and texture without downtime.
There is a paucity of clinical data guiding the management of lung cancer in the elderly due to underrepresentation of the elderly in clinical trials.
There is a paucity of knowledge from population data about sex differences and their age variation in physiological determinants of longevity.
There is a paucity of research available on the effect of mindfulness on cognitive function.
There is a paucity of research exploring how spouses to older adults with multiple chronic conditions make meaning of their caregiving experience.
There is a positive association between aging and BMI.
There is a positive correlation between the frequency of donations in the first year and the total number of return to donations.
There is a possibility that several features in the elderly patients are different from those in the non-elderly subject with diabetes.
There is a pressing need to promote a lifelong vaccine schedule to increase vaccination against VPDs during the different stages of life.
There is a public health demand to prevent health conditions which lead to increased morbidity and mortality among the rapidly-increasing elderly population.
There is a rapidly growing number of persons reaching extreme age limits.
There is a realistic hope for the preservation of self-determination and independence in the long term.
There is a relationship between high levels of inflammatory markers and low adhesion to the practice of physical activity in the older population.
There is a significant association between olfactory dysfunction and more prominent nigrostriatal denervation in the elderly.
There is a significant association between younger age and better preoperative function and the likelihood of experiencing improvements beyond @number@ yr.
There is a significant body of literature demonstrating that accelerometers placed at various locations on the body can provide the data necessary to recognize walking.
There is a significant desire by patients to reverse the signs of aging caused by photodamage.
There is a significant variation of CT between children of the same age.
There is a similar overlap and dissociation between neurologic and hematologic manifestations of inborn errors of folate and vitamin B12 metabolism.
There is a statistically difference at T2 values with and without subarticular cysts , marginal osteophytes , synovial thickening and effusion.
There is a statistically significant positive correlation between vitamin D concentration and age in late postmenopausal period.
There is a striking similarity between the signalling aspects of these two processes.
There is a strong case for the identification of these children and the development of appropriate interventions.
There is a strong demand to integrate these data from various resources into one open platform.
There is a substantial and growing number of older adults who misuse alcohol , psychoactive prescription drugs , and / or other substances.
There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist.
There is as yet controversy on serum Lp ( a ) concentrations in the elderly population.
There is as yet limited evidence as to whether any particular antidiabetic agents may influence cancer risk.
There is a tightly controlled feedback loop between peripheral tissue sensitivity and β-cell and L-cell ( GLP-1 ) responses.
There is a vast amount of evidence from psychological studies that the amount of parent-child interaction affects the development of children's verbal skills and knowledge.
There is a wealth of evidence indicating close ties between the nutrient signaling pathway and the intracellular stress response.
There is a well-documented shortage of physician researchers , and numerous training programs have been launched to facilitate development of new physician scientists.
There is a wide body of literature favoring nephron-sparing approaches.
There is a wide range of cognitive performance seen in this population.
There is clear and consistent evidence that regular physical activity is an important component of healthy lifestyles and fundamental to promoting health and preventing disease.
There is clear evidence of a deficit in episodic memory for older adults compared to younger adults.
There is clear potential to apply these marker types more widely in ecological studies.
There is concern that androgen replacement in older men may increase prostate size and symptoms of benign prostatic hyperplasia.
There is conflicting evidence as to whether living alone , being unmarried , or having a low income / worth is associated with nonadherence.
There is conflicting evidence regarding the influence of vitamin D supplementation ( @date@ , @percent@ reported significant reduction ) .
There is considerable evidence that damage to polyunsaturated fatty acids tends to reduce membrane fluidity.
There is considerable evidence to suggest that this agent is safe during pregnancy.
There is considerable uncertainty as to which model is most cost-effective and should therefore be mandated.
There is consistent evidence for a central role of mitochondrial dysfunction in these pathologies.
There is consistent evidence that multifactorial interventions reduce falls ( @date@ , @percent@ reported significant reduction ) .
There is controversy about which dietary assessment method and what person's characteristics are associated with greater under-reporting rates.
There is controversy as to whether maternal age exerts an influence on the contractility of human myometrium in pregnancy.
There is controversy whether ezetimibe modifies the plasma clearance of chylomicrons.
There is currently a lack of validated histologic grading schemes for cervical spine degeneration.
There is currently enormous interest in studying the role of the microbiome in health and disease.
There is currently much interest in determining the number of glomeruli , and thereby nephrons , in the kidney.
There is currently no standard criterion for determining abnormal test scores in neuropsychology ; thus , a number of different criteria are commonly used.
There is currently significant interest in identifying molecular markers of diagnostic and prognostic value for AAA.
There is documented widespread human exposure to parabens , and some experimental data suggest that they act as estrogenic endocrine disruptors.
There is emerging evidence of increased antiretroviral drug exposure in older individuals , but the evidence this leads to increased toxicity is less clear-cut.
There is encouraging , but limited , evidence of a cardioprotective effect of cranberries mediated via actions on antioxidant capacity and lipoprotein profiles.
There is even some evidence that ROS induction is required to mediate positive effects of calorie restriction and physical exercise on organismal fitness and longevity.
There is ever increasing data on biomedical relevant network interactions for the aging process at different scales of time and space.
There is evidence for mediation with life events and weekly stress events , but not with global stress.
There is evidence for sex-specific effects of individual , guideline-recommended drugs used for treatment of chronic heart failure.
There is evidence from epidemiologic data that cataract is more common in women than men.
There is evidence of a positive association between both whole brain volume and white matter ( WM ) volume and muscle size.
There is evidence of excitotoxicity , neuroinflammation , upregulated arachidonic acid ( AA ) cascade signaling and brain atrophy in BD patients.
There is evidence that all three conditions are reversible and all three appear to share common inflammatory drivers.
There is evidence that AMD is linked to exposure to short wavelength electromagnetic radiation , which includes ultraviolet , blue and violet wavelengths.
There is evidence that blood pressure ( BP ) is associated with muscle function in middle age.
There is evidence that brain-derived neurotrophic factor ( BDNF ) could be a central player in this relationship.
There is evidence that deficient temporal resolution contributes to this difficulty.
There is evidence that each of these regulates responses to cellular stresses , including oxidative stress and depolarization of the mitochondrial membrane.
There is evidence that , in older adults , dual-task performance can be improved by training.
There is evidence that insular cortical thickness shows age related decreases that parallel age related increases in future orientation and planning.
There is evidence that our ability to detect activations in task fMRI is highly dependent on the preprocessing steps used to control noise and artifact.
There is evidence that particularly balance and resistance training are effective in counteracting these neuromuscular constraints in both children and seniors.
There is evidence that persistent psychiatric disorders lead to age-related disease and premature mortality.
There is evidence that revascularization brings no additional benefit , at least in low-risk and stable atherosclerotic renal artery stenosis.
There is evidence that variation in approach can affect the values recorded.
There is evidence to suggest that the hematopoietic stem cell displays increasing erythropoietin ( EPO ) resistance with age.
There is extensive literature on the chemical constituents and bioactivities of ginseng.
There is fear of increasing inequality in health and in access to health care.
There is few information about the cost of wound treatment in Brazil.
There is further considerable evidence that aging is associated with increased proinflammatory cytokine expression and that many of these cytokines can contribute to EPO insensitivity.
There is general agreement that its natural history is unfavorable , as witnessed by a considerable body of evidences.
There is general skepticism whether mouse and human disease features are similar.
There is good evidence for medication review as part of a multifactorial intervention to reduce falls risk in community dwelling elderly.
There is great variation in the maximum life span of different species.
There is growing evidence about the influence of chemical exposures on specific molecular systems and mechanisms involved in cognitive and mental function.
There is growing evidence for alterations in iron homeostasis during aging that are exacerbated in neurodegenerative diseases such as Alzheimer's disease.
There is growing evidence of higher prevalence of chronic obstructive pulmonary disease ( COPD ) in the elderly.
There is growing evidence that fibromyalgia involves altered perception not only of pain , but also other sensory stimuli.
There is growing evidence that GAG concentration and sulfate content increase with age.
There is growing evidence that hypertension is the most important modifiable vascular risk factor for development and progression of both cognitive decline and dementia.
There is growing evidence that increased levels of the endogenous NO synthase inhibitor asymmetric dimethylarginine ( ADMA ) may contribute to endothelial dysfunction.
There is growing evidence that normal aging may produce declines in some motor tasks but not others.
There is growing evidence that personality traits are affected by many genes , all of which have very small effects.
There is growing evidence that probiotics have immunomodulatory properties , which to some extent are strain-dependent , and are strongly influenced by ageing.
There is growing evidence to suggest that aging is accompanied by enhancement in psychosocial well-being , despite age-related declines in physical and cognitive functioning.
There is growing interest in the influence of early-life development on clinical manifestations of late-life diseases.
There is growing interest in using patient-directed incentives to change health-related behaviors.
There is growing interest to determine how anesthesia affects the development or progression of AD.
There is high prevalence of OSA in the elderly.
There is , however , a lack of clinical practice guidelines about how to respond to these situations.
There is , however , a lack of mortality data , in comparison to incidence data , from the last decade in particular.
There is however limited data for individuals older than @number@ years.
There is , however , limited work examining the interaction of age and acute alcohol consumption.
There is , however , little cross-national comparative evidence on the prevalence of sleep disturbance and its association with age.
There is , however , no evidence to date that primordial follicles are compromised.
There is however , the need to monitor the elderly resident's safety , physical health and brain function.
There is huge demand for a wide range of chemicals to be assessed for such potential for the sake of public health.
There is impact on referrals to the outpatient first consultations of gastroenterology , mainly in rural setting.
There is increasing appreciation that mitochondria serve cellular functions beyond oxygen sensing and energy production.
There is increasing awareness that childhood circumstances influence disease risk in adulthood.
There is increasing evidence corroborating an association between diabetes mellitus and bone.
There is increasing evidence for influence of Alzheimer's proteins and neuropathology on ischemic brain injury.
There is increasing evidence that bone and vascular calcification share common pathogenesis.
There is increasing evidence that children with autism spectrum disorder ( ASD ) have differences in brain growth trajectory.
There is increasing evidence that epigenetic modifications may become compromised in aging and increase susceptibility to the development of neurodegenerative disorders such as Alzheimer's disease.
There is increasing evidence that essential tremor ( ET ) is a complex and heterogeneous disorder with nonmotor features including cognitive deficits and sleep problems.
There is increasing evidence that improved nutrition can reduce the risk of developing disability in older age.
There is increasing evidence that many chronic inflammatory diseases represent an acceleration of the ageing process.
There is increasing evidence that nutrient-sensing machinery is critically involved in the regulation of aging.
There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases.
There is increasing evidence that transcriptional reprogramming caused by epigenetic modifications can be passed from parents to offspring.
There is increasing evidence to suggest that elevated plasma levels of fibrinogen are associated with late-life cognitive performance.
There is increasing interest in using newer agents , although their safety and efficacy in transplant recipients remains to be conclusively established.
There is increasing research evidence to support the application of meditation techniques to help improve cognition and memory in patients with neurodegenerative diseases.
There is information indicating that the variations induced by the menstrual cycle may influence the capacity of young women to respond to stress.
There is insufficient evidence to determine whether mild TBI is associated with cognitive deficits @number@ months or longer postinjury.
There is intense controversy over whether low-carbohydrate or low-fat diets are more efficacious for weight management.
There is intriguing evidence suggesting that protein SQSTM1 / p62 , together with autophagy , has a role in the pathology of different degenerative diseases.
There is less research on age effects on the ability to reverse a learned path.
There is limited evidence about the separate contributions of a woman's age , menopausal status and age at menopause to the incidence of hip fracture.
There is limited evidence for the efficacy of most BS.
There is limited evidence for the hypothesis , and research has not tended to clearly distinguish age dedifferentiation from ability differentiation and other age-related phenomena.
There is limited evidence on how to perform routine cognitive screening in HIV clinical settings.
There is limited information about its sensitivity , specificity , positive and negative predictive values , and , in particular , responsiveness.
There is limited quantitative data on soft tissue aging of the face.
There is limited research examining perceived discrimination in older adults , and its effects on health in later life.
There is limited research exploring how domestic water restrictions imposed as a result of drought conditions impact upon the lives of independently living older people.
There is limited research into strategies that reduce such risks.
There is limited research on the barriers to adoption for interRAI electronic assessment tools , and none relating to the New Zealand health sector.
There is limited understanding of aging experiences across generations.
There is little attention to social function in the treatment of depression.
There is little data considering relationships among human RNA , demographic variables , and primary human cell physiology.
There is little documented clinical evidence of the objective benefits of this therapy.
There is little empirical evidence available about the optimal interval for screening , making this a subject of debate.
There is little evidence that a daughter's death has a negative effect on either maternal or paternal wellbeing.
There is little information available about the influence of serum magnesium on ED.
There is little information available on the autochthonous HEV infection in highland inhabitants ( Tibet , average elevation > 3000m ) of China.
There is little information on the cognitive profile of individuals with MCR syndrome and its overlap with mild cognitive impairment ( MCI ) syndrome.
There is little information on the regional distribution of food allergy in Australia.
There is little knowledge on the relationships between neighborhood environments and trajectories of social engagement among physically and economically vulnerable older adults.
There is little known regarding the factors that lead physicians in China to pursue careers in clinical neurosciences.
There is little pharmacotherapy data on mania in OABD.
There is little previous study of the 3D hand loading that is required to open these products.
There is little published data on goal-setting instruments in geriatric rehabilitation.
There is low-quality evidence that IFN-α alone increases mortality but moderate-quality evidence on decreased AEs compared to IFN-α plus bevacizumab.
There is marked heterogeneity in the degree to which various FS estimate frailty and in the identification of particular individuals as frail.
There is marked regional heterogeneity in liver donor growth.
There is marked variability in both onset and rate of episodic-memory decline in aging.
There is mounting research to suggest that cognitive and motor expertise is more resistant to age-related decline than more general capacities.
There is much ambiguity regarding the term \ "nursing home \ " in the international literature.
There is much controversy regarding the use and timing of enteral feeding support in these patients with dysphagia.
There is much evidence about the HC ingestion positive effect over degenerative joint and bones diseases.
There is much room for improvement in CHC to enhance customer satisfaction.
There is much to be said for ' aged heterogeneity' , the concept that individual differences increase as people age.
There is need for future studies to implement and evaluate interventions to reduce the risk of ADR-related admissions in elderly populations.
There is need for models that explain and predict positive outcomes.
There is need to implement patient-centered care which involves these interactions rather than merely paying attention to individual diseases.
There is no accurate standard reference range on its characteristics after surgeries for gastrointestinal or retroperitoneal tumors.
There is no age at which ends the expression of sexuality and intimacy.
There is no age-related change in the cross-sectional area of the fornix , but there is a significant loss of myelinated nerve fibers.
There is no apparent association between TRT and the development of prostate cancer.
There is no available method of age-prediction for biological samples.
There is no clinically relevant difference in the efficacy of basal-bolus versus premixed insulin regimens for HbA1c decrease in type @number@ diabetic patients.
There is no complete and specific interprosthetic femoral fracture classification system that indicates treatment and prognosis in the literature.
There is no consensus about pharmacological treatment for this population , so it is important to structure non-pharmacological interventions for increasing their cognitive reserve.
There is no consensus as to whether the precuneus , a hub in the functional connectome , acts as part of the default network.
There is no consensus definition of agitation and no widespread agreement on what elements should be included in the syndrome.
There is no consensus in the literature on whether the spatial and temporal gait parameters could identify elderly people at risk of recurrent falls.
There is no consensus on what constitutes a positive family history , and ascertainment is unreliable for many reasons.
There is no consensus regarding vein in forearm.
There is no consensus whether CTR gene polymorphism plays a role in affecting pathogenesis of osteoporosis.
There is no curative treatment , except allogeneic stem cell transplantation for a selected group of patients.
There is no cure for the disease and current treatments are only symptomatic relieve.
There is no direct equivalent of the Hypertension in the Very Elderly trial ( HYVET ) study of antihypertensive patients in the extreme elderly.
There is no documented example of truly end-stage neurofibrillary pathology coexisting with intact cognition.
There is no effective drug treatment , so I can only recommend symptomatic and moderate muscle training.
There is no effective treatment for amyotrophic lateral sclerosis ( ALS ) , a devastating motor neuron disease.
There is no evidence for a causal effect of additional children on the probability to suffer from depression for elder men.
There is no evidence that premature ejaculation is more common in older age.
There is no existing record for profiling of symptomatic hyponatremia in elderly Indian subjects.
There is no firm evidence that lifestyle-related factors are the cause of this gender discrepancy.
There is no general agreement about the effects of ethnicity , gender and age on RSSC.
There is no information regarding Cox-2 expression in B cells from older human subjects.
There is no interaction between these two exposures.
There is no known cure but research is ongoing.
There is no known drug or agent that can delay or prevent the AD and its progression.
There is no OC postnatal peak , but levels are higher than the adult reference interval throughout childhood.
There is no physiological anaemia in the elderly.
There is no previous research on this potential effect in patients with hip fracture who receive urinary catheters.
There is no record of any other surviving centenarian after @number@ in Es Migjorn Gran.
There is no relation between the LTL and the structure of LV.
There is no remarkable difference between the costs of demented patients living at home and in nursing homes , from the societal point of view.
There is no safe distance from FR to ICA.
There is no seasonal swing in hip fracture incidence.
There is no significant association of immunophenotypes with ages among different age groups of adult B-ALL.
There is no significant difference in the detection of RARβ2 promotor methylation between these two methods ( p < @number@ ) .
There is no single definition of polypharmacy.
There is no standard treatment for locally advanced prostate cancer.
There is no statistically significant relationship between initials and longevity for Major League Baseball players when a correct test is applied to independently selected initials.
There is no strong indication of short-term cognitive benefit of hormone use after natural menopause , but clinical trial data are sparse.
There is no study in a Thai population.
There is no study that compares the elderly cases of aSAH who receive the definitive treatment with those who treated conservatively.
There is no test for its definitive diagnosis in routine clinical practice.
There is not , however , a decreased need for sleep and sleep disturbance is not an inherent part of the aging process.
There is not medical evidence of effectiveness with any other measures , as hormonal therapies or reconstructive surgery.
There is not one systems biology of aging , but two.
There is often no outwardly visible phenotype.
There is only a program of development up to the state of maturity , and then the organism should be able to maintain itself limitlessly.
There is only limited longitudinal research examining the relationship between different dimensions of social relationships and change in well-being over time.
There is patient demand for similar fillers that may be longer lasting.
There is poor evidence regarding voriconazole prophylaxis in patients with neutropenia ( CII ) .
There is potential to organize select health services regionally to improve further efficiency.
There is preliminary evidence for the efficacy of attachment-based interventions in dementia.
There is probably no sexual dimorphism in the prevalence of brown adipose tissue.
There is recent evidence of a significant role of DHEA in frailty syndrome and as predictor of mortality.
There is regional variation in aortic distensibility with aging.
There is relatively large number of comparative studies confirming strong correlation between aging and prevalence of nocturia.
There is relatively little published on the socioeconomic distribution of this burden in older people.
There is relatively little support for people with HI or ear disease in the Pacific region.
There is remarkable variability in health across the age spectrum , from fit to frail and compromised.
There is robust evidence linking interindividual differences in positive affect ( PA ) with adaptive psychological and physical health outcomes.
There is room for reducing the sodium content of soup , while the sodium in bread should be reduced progressively.
There is scant clinical or other relevant information related to this topic , as the phenomenon of gender incongruity has been largely misunderstood and underreported.
There is scientific evidence that the coincidence of hearing and vision loss is more frequent than expected by the prevalence of individual disorders.
There is significant epidemiological heterogeneity between NHL subtypes , yet cancer registries have tended to consider NHL as a single entity.
There is significant interest in understanding inflammatory responses within the brain and spinal cord.
There is significant oxidative damage in peripheral blood early in the process of neurodegeneration.
There is some controversy regarding fibril length in adult tendon , with mechanical data generally supporting discontinuity while structural investigations favor continuity.
There is some debate over the relative impairment of recollection and familiarity in mild cognitive impairment ( MCI ) .
There is some evidence for clinical and genetic overlap between frontotemporal dementia and schizophrenia.
There is some evidence suggesting that obese children show increased left ventricular mass and also increased atrial size , although with conflicting results.
There is some evidence that treatment in chronic pain patients can reduce pain and simultaneously improve QoL.
There is some research showing that gap detection can be evaluated using an electrophysiological procedure.
There is still enormous effort required in order for Japan to recover from the damage , not only financially , but psychosocially.
There is still , however , a need for further understanding of how chronic conditions affect these health aspects.
There is strong evidence demonstrating age-related differences in the acceptability of foods and beverages.
There is strong evidence for the effectiveness of rehabilitation in better managing stroke and its related disabilities.
There is strong evidence suggesting that physical activity ( PA ) is important in maintaining physical performance in old age.
There is strong evidence that Alzheimer's disease ( AD ) pathology starts decades before clinical onset.
There is strong evidence to support the management of many chronic diseases presenting in - or extending into - old age.
There is substantial evidence for the presence of oxidative , proteotoxic and metabolic stresses in aging brain.
There is substantial overlap between our iron loci and loci affecting erythrocyte and lipid phenotypes.
There is substantial scientific disagreement and controversial results , regarding even the basic nature of aging and the path to longevity.
There is sufficient evidence to support the role of dietary multivitamin / mineral supplements for the decreasing the risk of age-related cataracts.
There is sufficient potential for improvements in geriatric pharmacotherapy in terms of drug safety and effectiveness.
There is synergistic effect of HT and aging on LA volume and phasic function.
There is the need to create and evaluate innovative models of care of multiple chronic conditions in the late life course.
There is therefore a requirement for more of the rudimentary patient testing to be performed outside of the hospital environment.
There is therefore great interest in developing non-invasive metrics for estimating brain CMRGlu.
There is the reverse correspondence between the telomere length and the plasma CRAMP level.
There is thus an enormous opportunity to foster successful aging and to increase functional life years through expanded efforts aimed at CVD prevention.
There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases , and in particular in synucleinopathies.
There is weak evidence to suggest envelope colour may affect consent into a trial.
There is widespread evidence of under-recruitment of older people to research studies , notably randomised controlled trials of interventions.
There is widespread evidence that memory deteriorates with aging , however the exact mechanisms that underlie these changes are not well understood.
There is wide variability in phenotype even within affected families , raising questions about the determinants of the progression of disease and age at onset.
The Rejuran® is a new filler product made from purified polynucleotides.
The rejuvenation techniques are numerous , nuanced and gradual.
The related 53BP1 gene is known to positively regulate repair of DSBs outside of S phase , but via the NHEJ pathway.
The related impact on daily activities for elderly persons with balance problems was quantified.
The related side effects in the elderly patients were almost equal to those in the younger.
The relation between ACTN3 R577X polymorphism and muscle mass in women has been reported , but its relation to age remains unclear.
The relation between BAT and peptide hormones secreted from the gastrointestinal system ( GI ) and involved in appetite regulation is not known in humans.
The relation between daily functioning , nutritional status and AD warrants further investigation.
The relation between dietary protein and fracture risk is unclear.
The relation between DTI parameters in both WML and NAWM and cognitive performance was most pronounced in subjects with severe WML.
The relation between fibrosis and electrophysiological parameters such as conduction , fractionation of electrograms , abnormal impulse initiation as well as arrhythmogenicity is discussed.
The relation between functions of reminiscence and mental health has been studied elaborately in older adults.
The relation between marine omega-3 fatty acids and T2D was observed in hypertensive and nonhypertensive subjects and in women who reported infrequent fish consumption.
The relation between peripheral muscle strength and PCF was mediated by MIP.
The relation between physical health and subjective wellbeing is bidirectional.
The relation between the percentage of normal forms with pregnancy outcome after IVF / ICSI.
The relation between the physiologic and subjective stress responses is inconsistently reported across studies.
The relation between vitamin D and PTH was independent of age , gender , BMI and kidney function.
The relation of CA 19-9 levels to metabolic control and microvascular complications in patients with diabetes was also investigated.
The relation of conscientiousness and the neuropathologic markers to cognitive decline was assessed in mixed-effects change point models to accommodate nonlinear cognitive decline.
The relation of development and aging with models of visual anisotropies and their influence on low-level visual processing remain to be established.
The relation of prevalent obesity to household income and wealth was also evaluated using logistic regression models.
The relation of resilience index to known risk factors for AD and related variables was examined.
The relations between baseline confocal parameters and @number@ months IOP were analyzed.
The relations between the Framingham General Cardiovascular Risk Profile , cognitive task performance , and DMN function require further study.
The relationship among diabetes mellitus , insulin , and AD is an important area of investigation.
The relationship among glucose status , age , and AD was analyzed with general linear models by adjusting for factors influential on AD.
The relationship-based skill set and scope of social work practitioners provides opportunity for the development , facilitation , and evaluation of intergenerational programs.
The relationship between AAR and age was good enough to serve as basis for age estimation , but worse than known from dentinal proteins.
The relationship between aASM and IQS was assessed adjusting for age and gender.
The relationship between acne and diet , predominantly the role of high glycemic load diets and dairy consumption have recently gained increased interest.
The relationship between age and gait characteristics in people with and without medial compartment osteoarthritis ( OA ) remains unclear.
The relationship between age and PS did not significantly change after accounting for uncinate FA , suggesting that the observed age associations occur independently.
The relationship between age and susceptibility was also explored.
The relationship between age and these parameters were then examined.
The relationship between age , axial length and astigmatism was analyzed respectively.
The relationship between age , ROS and human skin keratinocyte migration is not clearly understood.
The relationship between AGEs , RAGE , and inflammation has not been well characterized.
The relationship between aging and lung disease was discussed in several oral symposiums and poster sessions at the annual ATS meeting.
The relationship between altered platelet functions and thrombotic and inflammatory disorders in older adults is highlighted.
The relationship between ambulatory BP patterns and cognitive function in community-living older adults is unknown.
The relationship between baseline adiposity to muscle ratio and incident physical limitation was examined by logistic regression.
The relationship between cardiovascular risk factors and vascular remodeling is a relatively new area of investigation.
The relationship between census and mortality was stronger when the census was composed of higher acuity patients ( interaction P value < @number@ ) .
The relationship between cognitive function and gait has recently received increasing attention.
The relationship between dementia and cancer is complex.
The relationship between depression and hypertension was partially mediated by social support ( given ) , while the relationship between depression and hypertension was not.
The relationship between depression and obesity status was examined in both the full sample and in sub-samples stratified by gender.
The relationship between depressive symptomology and anti-depressant prescription was also significantly associated with falls ( P = @number@ ) .
The relationship between diminishing estrogen levels in women caused by ovarian failure and the development of postmenopausal osteoporosis is widely recognized.
The relationship between eating behaviors , food intake , and mental health and the occurrence of obesity in older adults has rarely been investigated.
The relationship between educational attainment and longevity was similar for black and white participants.
The relationship between eGFRcys and outcomes appeared linear but varied by age.
The relationship between energy expenditure and energy intake throughout an individual's lifetime is far more complicated than previously thought.
The relationship between GFR decline and BP was analyzed in linear mixed models.
The relationship between higher depressed mood subscale scores and larger volumes in the left inferior temporal lobe withstood Monte-Carlo correction for multiple comparisons.
The relationship between hippocampal volume and recall performance was more pronounced among those with lower scores on a global cognitive measure.
The relationship between homocysteine levels and cognitive decline was studied using multivariate regression models , and by comparing high versus low homocysteine quartile groups.
The relationship between hormones and mortality was tested by Cox proportional hazard models adjusted for age , sex , and confounders.
The relationship between IGF-binding proteins @number@ and @number@ ( IGFBP3 and IGFBP1 ) with risk of cardiovascular disease remains unclear.
The relationship between knee loading and BMLs is not yet completely understood.
The relationship between lipids and cardiovascular events in the extreme elderly is unclear.
The relationship between LLC and LBP has immense clinical significance , because it serves as the basis of therapeutic exercises for treating and preventing LBP.
The relationship between LLDs and osteoarthritic knee pain is not well understood.
The relationship between LOH and its effects on both sexuality and fertility are also considered.
The relationship between maternal age and individual parameters was evaluated using linear regression analysis.
The relationship between micro-tensile bond strength and collagen degradation was analyzed by calculating their Pearson's correlation coefficient.
The relationship between MRI findings and the values of maximum standardized uptake value ( SUVmax ) on FDG PET / CT was analysed.
The relationship between MS and LVMI lost its significance when BMI was included in the model , and remained significant for IMT.
The relationship between multimorbidity and subjective memory complaints differed between men and women and between age groups.
The relationship between muscle pathology and extracellular myomiR release is complex , and incompletely understood.
The relationship between neuropathology and clinically manifested functional and cognitive deficits is complex.
The relationship between nutritional risk and subsequent depressive symptoms was stronger than the relationship between co-morbidities and ADL score and subsequent depressive symptoms.
The relationship between obesity , aging , and HR-QOL is , however , much more complex than generally acknowledged and is difficult to disentangle.
The relationship between obsessive-compulsive symptom severity and functional impairment was not moderated by patient insight , resistance against obsessive-compulsive symptoms , or anxiety sensitivity.
The relationship between older adults ' UFOV performance and event-related potential ( ERP ) components reflecting visual processing was examined.
The relationship between osteoarthritis ( OA ) and osteoporosis ( OP ) , the two most common skeletal disorders related to aging , is controversial.
The relationship between outcomes and body mass index ( BMI ) was examined as well.
The relationship between oxidative stress and cognitive performance was also evaluated by the Mini Mental State Examination ( MMSE ) .
The relationship between physical activity levels and disease rates has become an important health-related concern in the developed world.
The relationship between PrCCI and mortality was assessed using a Survival analysis.
The relationship between PSA and testosterone levels was investigated in both groups and in patients aged < 60 years.
The relationship between QUS measures and skeletal age is best described by a cubic growth curve in boys and a linear pattern among girls.
The relationship between recent episodes of poor sleep and cognitive testing performance in healthy cognitively intact older adults is not well understood.
The relationship between reduced salivary flow rate during the follow-up period and its predictors was evaluated after adjustment for confounding factors.
The relationship between renal function and 1-year mortality was evaluated using Kaplan-Meier curves and Cox regression analysis including potential confounders.
The relationship between renal function and BMD was analyzed.
The relationship between risk factors and outcomes was assessed using logistic regression.
The relationship between serum folate and plasma cysteine is poorly understood.
The relationship between serum total testosterone and prostate cancer ( PCa ) risk is controversial.
The relationship between serum uric acid ( sUA ) and cognitive function is contradictory.
The relationship between sex and occurrence was studied.
The relationship between snacking and snackers ' diet quality and stress coping is a topic overlooked in research.
The relationship between SNs , age group , disc location and overall grades of lumbar disc degeneration were analyzed by multiple Logistic regression.
The relationship between SNs , age group , disk location , and overall grades of lumbar disk degeneration were investigated by multiple logistic regression analysis.
The relationship between stroke and changes in HRV during hemodialysis remains unclear.
The relationship between structures and permeation / toxicity of coumarins was elucidated.
The relationship between subjective physical health and depressive symptoms was moderated by self-efficacy and social support.
The relationship between SVD and atrophy requires further study.
The relationship between Tact proportions and schistosome infection intensity remained unchanged with age.
The relationship between telomere length and aerobic and muscular fitness is not well characterized.
The relationship between the dopaminergic system and gait parameters is poorly understood.
The relationship between the glutathione peroxidase and adenosine deaminase / xanthine oxidase , adenosine deaminase and xanthine oxidase was also determined.
The relationship between the health experiences of second-degree relatives and subjective life expectancy is much less pronounced.
The relationship between the mutation status of p53 and expression of SIRT1 was also investigated in @number@ fresh HCC tissues.
The relationship between the phenotype and serum serotonin is not well documented.
The relationship between these biomarkers and regional brain atrophy across the different stages of AD remains largely unexplored.
The relationship between the time constant of recovery and age was investigated ( Pearson's correlation coefficient ) .
The relationship between the two glands is mutual.
The relationship between the user's state and music sorted by listener's preference was also examined in this study.
The relationship between valence and arousal mainly showed the curvilinear relationship reported in previous studies.
The relationship between viscosity and aging is still controversial.
The relationship between wrinkle depth and echogenicity of subcutaneous tissue is particularly pronounced in the elderly.
The relationship in women appears less robust possibly due to gender differences in metabolic risk factors.
The relationship is likely confounded by smoking , complicating the interpretation of previous studies.
The relationship of adult children with intellectual disability also transmitted the effect of establishment of permanency planning on caregiving satisfaction.
The relationship of cell size and AF , a surrogate for LF concentration , is orderly and linear in both groups.
The relationship of childhood socioeconomic deprivation and parental substance abuse with adult well-being should be an important consideration in social policy planning.
The relationship of higher order problem solving to basic neuropsychological processes likely depends on the type of problems to be solved.
The relationship of HR measures with the presence of silent brain infarct and upper quartile of log WMHV ( log WMHV4 ) was analyzed.
The relationship of the remaining five gait variables with depressive symptoms was not significant in the fully adjusted models.
The relationship of the results of cold stress and autonomic symptoms observed by the main caretakers was also examined.
The relationship of these easily obtained parameters to standard functional , imaging , and pathological markers of sarcopenia deserves further study.
The relationship of these protein abnormal depositions in the aged brains with cognitive and motor functions were analyzed.
The relationship of Vit-D deficiency with circulating endothelial progenitor cells and endothelial dysfunction in type @number@ DM patients nonetheless remains unclear.
The relationships among ER stress , apoptosis , and cancer are also discussed.
The relationships among MAP , memory decline , and hippocampal atrophy were also examined.
The relationships between ABPM indices and cardiac damage ( expressed by shape and function ) were assessed using ridge regression analysis.
The relationships between all criteria , as well as technical or applied inferences / consequences from this study , are discussed.
The relationships between Axis II personality disorders ( DSM-IV ) and the Five-Factor Model ( FFM ) were explored in older women.
The relationships between c / a and atherosclerosis-based conditions and risk factors for atherosclerosis were also evaluated.
The relationships between frailty and the risk of dementia , AD and death were evaluated through multivariable models.
The relationships between health , workforce participation and need for assistance in daily activities are complex.
The relationships between metabolite ratios and cognitive performance were analysed using Spearman correlation coefficients.
The relationships between muscle function and fatigue are complex.
The relationships between pain , memory , and the EEG will be discussed.
The relationships between phantosmia and demographic , genetic , health-related , and behavioral variables were analyzed with hierarchical logistic regression analyses.
The relationships between psychological HRQOL , identity stigma , and prior military service were largely explained by depressive symptomatology.
The relationships between RT performance and executive functions were examined with structural equation modeling ( SEM ) .
The relationships between SCH and serum lipid parameters in each age group were evaluated after adjustment for thyroid hormones and common confounding factors.
The relationships between sRAGE and other clinical markers were assessed by Pearson's correlation analyses and multiple linear regression analyses.
The relationships between T2D and neural dysfunction are regulated by several modifiers.
The relationships between TA and known prognostic factors were also analyzed.
The relationships between the ALFF signal values in different brain regions and clinical features in MB patients were investigated using correlation analysis.
The relationships between the measurements were all in the expected direction , and the magnitude of the convergent-validity coefficients was considered as acceptable.
The relationships between these issues and clinical outcomes ( death , initiation of dialysis and other adverse events ) will be evaluated , if possible.
The relationships between tissue thickness , age , and sex were investigated.
The relationships of AAC with both inflammation and oxidative-stress variables were evaluated.
The relationships of FVIII and rFIX clearance ( CL ) with body weight could be described by allometric expressions.
The relationships of these behaviors with cognitive function differed by MCI status ; associations were found only in participants without MCI.
The relationship was further analyzed by dividing the ROI into two : one above and the other below the deepest point of the wrinkle.
The relationship was less convincingly for hospitalizations , and falls were not explained well.
The relationship was not significant in non-hypertensive participants ( ß = -0.09 , p = 0.903 ) .
The relationship with MMPs is not explained.
The relations of asthma history and severity during follow-up to subsequent job changes were evaluated by Cox models.
The relations were independent of depressive symptoms , physical health and chronic disease status and were observed for both sexes at all older ages.
The relations were more prominent with advancing age , suggesting that aging-related cortical demyelination contributes to increased IIV.
The relative abundance of truncated forms was consistent and unaffected by vitamin K supplementation.
The relative benefits of fibre extracts compared with whole-grain fibre sources therefore represent a critical area in which additional research is needed.
The relative change in activity as a function of stimulus presentation rate showed differences between young and older participants.
The relative change with age was largest for the high cognitive and physical function component and smallest for active engagement with life.
The relative compositions of Tau , L-methionine , and Arg decreased in severe ocular surface disease subjects compared with non-ocular surface disease subjects.
The relative contributions of aging and recurrent affective episodes to these differences in bipolar disorder patients remain to be established.
The relative contributions of genetic and environmental factors to brain structure change throughout the lifespan.
The relative contributions of increased forward versus reflected pressure wave amplitude or earlier arrival of the reflected wave to elevated pulse pressure remain controversial.
The relative decrease in the success rate with donor ages @number@ to @number@ years was not observed until after year @number@
The relative expansion of ECW affects the validity of traditional SFBIA , which is lowered when estimating muscle CSA in the elderly.
The relative importance of alterations in phonetic segments vs. temporal patterns in a carrier phrase with accented speech also was examined.
The relative importance of GBS-ADL was evaluated in the full model.
The relative importance of the forward and reflected wave components in essential hypertension has not yet been fully elucidated.
The relative influence of the spatial switch of the target-speaker ( switch or repetition of speaker's direction in space ) was identical across age groups.
The relative length of the telomeric repeats of blood cell chromosomes from @number@ apparently healthy volunteers was measured by quantitative real-time polymerase chain reaction.
The relative level of cystatin C protein expression in human RPE in situ was assessed immunohistochemically in relation to age.
The relatively high prevalence of potentially curative kidney diseases in elderly individuals implicates the importance of renal biopsy in these patients.
The relatively perturbed genes were selected for each time point based on the proposed scoring measure denominated as perturbation scores.
The relatively random spiking times of individual neurons provide a source of noise in the brain.
The relatively stable 5-HT ( @number@ ) receptor binding with aging contrasts others in subtypes of receptors , which generally decrease with aging.
The relative MVPA thresholds were developed specifically for the Generation @number@ population sample.
The relative quantification of proteins using liquid chromatography mass spectrometry ( LC-MS ) has allowed researchers to compile lists of potential disease markers.
The relative ranking of stimuli was different for interest and pleasure.
The relative rate for birth cohorts before @date@ vs after was @number@ ( @percent@ CI , @number@ @date@ ) .
The relative reliability for all variables was excellent : ICC = .81-.91.
The relative risk factors of dry eye were gender , age , wearing contact lens , long-time using of eye solutions , taking anti-allergy drugs.
The relative risk of closure was significantly higher in zip code areas with a higher proportion of blacks or Hispanics or a higher poverty rate.
The relative risk of hypoglycemia was not significantly associated with HbA1c values.
The relative risk of usage among women in the PI group relative to controls was @number@
The relative role of protein turnover and cell turnover in muscle adaptation and in the establishment of functional muscle hypertrophy remains to be established.
The Relative Stress Scale evaluated caring burden.
The relative telomerase activity ( RTA ) in granulosa cells was detected using a modified quantitative-telomeric repeat amplification protocol assay.
The relative telomere length of 2BS cells was detected by fluorescence real-time quantitative PCR ( q-PCR ) .
The relative telomere length of leukocytes was determined by a real-time fluorescence quantitative polymerase chain reaction ( PCR ) .
The relative value was defined as the ratio between the TT-TG distance and the total width of the distal femur.
The release of HCV particles is still not fully understood.
The release of hemoglobin ( Hb ) occurs in some infectious and autoimmune diseases characterized by inflammation.
The release of high mobility group box @number@ ( HMGB1 ) and phosphorylation of mitogen-activated protein kinase ( MAPK ) were determined by ELISA.
The release of procoagulant-rich microparticles from neutrophils accelerates the pathogenesis of inflammatory thrombosis.
The relevance of deterioration with age depends on the nature of the work undertaken.
The relevance of the different approaches for the analysis of mitochondrial DNA repair mechanisms and of aging is discussed.
The relevance of these findings to neuronal cell death is discussed.
The relevance of these loci to women of African ancestry has not been previously studied.
The relevance of this classification to future research in the field of emerging adulthood is discussed.
The relevance of this factor deserves further investigation.
The relevance of this findings in other ethnicities or associated with different dietary pattern should to be further investigated.
The relevance of this result is discussed in a preclinical application scenario.
The relevance , validity , and utilization of cognitive frailty , however , is presently unclear.
The relevant intrinsic risk factors are muscle strength , balance capacity , reactive power , dual tasking and sleep disturbance.
The relevant legislation exists but there are still issues regarding the implementation of specially developed social services for older persons.
The relevant pathways through which the benefits of physical activity are conveyed are also discussed.
The relevant properties are discussed.
The reliabilities of the scales of the Dutch version of the MCQ were all high ( all Cronbach's αs ≥ @number@ ) .
The reliabilities of the scales were good ( α > .70 ) to acceptable ( α = .66 and @number@ ) .
The reliability and acceptability of these measures were investigated in older adults.
The reliability and validity of the P-CAT were analyzed , within the frameworks of Classical Test Theory and Item Response Theory models.
The reliability of applying the American College of Rheumatology ( ACR ) criteria for hand osteoarthritis to community-dwelling older adults will also be investigated.
The reliability was tested , and the correlation of the grade with the severity of the disc and facet joint degeneration was examined.
The reliable neuroimaging finding that older adults often show greater activity ( over-recruitment ) than younger adults is typically attributed to compensation.
The Religious Orders Study and the Rush Memory and Aging Project are both cohort studies of aging and dementia that include organ donation at death.
The reluctance to acknowledge sexual bereavement may create \ "disenfranchised grief \ " leaving the bereaved unsupported in coping with this aspect of mourning.
The remaining activity of blood PON1 , cholinesterases and brain AChE in PON1 pretreated animals after nerve agent exposure correlated with the survival rate.
The remaining animals are still healthy @number@ months post-treatment.
The remaining can be a novel disease-disease relationship based on gene / protein similarity.
The remaining carriers did not differ from controls on motor scores at baseline or follow-up.
The remaining genes are involved in different molecular functions , including apoptosis and gene expression regulation.
The remaining half had considerably poorer spatial acuity at the more peripheral regions of frontal space.
The remaining junction components frequently drag in trails behind invading knockout parasites and illustrate a malformed complex without RON8.
The remaining nephrons are therefore hyperfiltering from birth.
The remaining @number@ articles were extensively reviewed.
The remaining @number@ participants made up the group without diabetes.
The remaining @number@ patients ( @percent@ ) comprised the old group , with a median age of @number@ y.
The remaining @number@ patients , with a mean age of @number@ years , were included.
The remaining @number@ specimens were not aged and did not receive surface treatment.
The remaining @number@ were types @number@ @number@ and @number@
The remaining question is whether these changes can be attributed to the late effects of treatment or to normal effects of aging.
The remaining significant S-ABR effects were decreased amplitude at the onset and significantly delayed offset responses in the older group.
The remaining studies consisted of prospective observational studies , a retrospective cohort study , a case-control study and five non-randomised control trials.
The remaining TREM2 variants were found in @number@ patient , respectively , and were absent in controls.
The remaining twenty-one were allocated to a control group ( CG ) .
The remaining two feature groups are developed to resolve the difficulties caused by interpersonal EEG signal differences.
The remaining US samples were homozygous for the alanine ( A673 ) allele.
The remaining variables showed no significant intergroup modifications.
The remaining variance in these glycans strongly correlated with physiological parameters associated with biological age.
The remaining women ( n = @number@ ) were considered cognitively normal.
The remarkable presence of indigested meat fibre and several mucous dense filaments were observed.
The REM atonia index was significantly decreased in the ALS patients , and the number of chin movements / hour tended to increase.
There may also be gender differences in this association.
There may also be little or no effect on emotional well-being or quality of life , overall behavioural problems and cognition.
There may be age differences in the elimination kinetics of PFASs.
There may be an insufficiency in different steps of the enzymatic antioxidant systems in patients with PMO without treatment.
There may be some overlap among included meta-analyses.
There may , however , be other yet unidentified determinants of neuropathy in PD.
There might also be subgroup effects because of the carriage of apolipoprotein Eε4 alleles or risk factor burden.
There might be a protective effect of adiposity , compatible with the \ "obesity paradox. \ "
The remission-induction phase was a median of @number@ days for both groups.
The remnants of the amnion preparation were placed in a sterile container and transferred to a class B environment , where the primary cultures began.
There , mutant tau depleted PSD-95 , resulting in smaller postsynaptic densities and impaired synaptic localization of NMDA receptors ( NMDARs ) .
The renal dilatation had resolved by @number@ months in approximately @percent@.
The renal function of those with a high AIX was lower than those with a low AIX [ ( @number@ ± @number@ ) ml.min.
The renal microvasculature is targeted during aging , sometimes producing chronic kidney disease ( CKD ) .
The renewal of intracellular proteins declines which creates a negative balance between the daily protein losses and the capacities to renew them.
The renin-angiotensin system ( RAS ) plays a critical role in placentation and nephrogenesis.
The renin angiotensin system seems to be the key mechanism involved in aging.
There now are well-established methods for addressing missing data in longitudinal studies.
The repeatability of the data reflecting the postural control mechanisms in young children is still not well enough explained.
The repeatability of the stability indices is poor from @number@ to @number@ year of life but increases significantly from @number@ to @number@ year of life.
The repeatability of this method was found to be better than the earlier box-counting method.
The Repeatable Battery for the Assessment of Neuropsychological Status ( RBANS ) has become a popular cognitive screening instrument , particularly in elderly patients.
The repeated narratives of elderly adults , on the other hand , tend towards prolixity.
The repeat expansion in the C9ORF72 gene is a rare , but possible , cause of schizophrenic spectrum disorders.
The repeat expansion was observed in only @number@ ( @percent@ ) of the familial and @number@ ( @percent@ ) of the sporadic cases.
The repetition priming effect refers to an increase in performance for repeated items compared to unrepeated items.
The repetitive exposure of skin to ultraviolet B ( UVB ) preferentially elicits wrinkling while ultraviolet A ( UVA ) predominantly elicits sagging.
The replenishment of COL17 in the neonatal epidermis of COL17-null mice reverses the proliferative IFE phenotype and the altered Wnt signaling.
The replication phase consisted of @number@ case and @number@ control samples.
The replication study was comprised of @number@ community-dwelling senior European Caucasians.
The replicative potential is higher and telomeres are longer in female hCSCs than in male hCSCs.
The reported association of hypoglycemia with dementia and falls should also be examined.
The reported clinical scores ( United States Public Health Services and Californian Dental Association ) showed considerable heterogeneity between trials and could not be combined.
The reported disparate findings may be related to the task-dependent nature of fatigue and the limited number of studies exploring nonisometric contractile function and aging.
The reported LTR of stroke and AMI for middle-aged adults is substantial.
The reported methodology is inspired by genomic sequence annotation using similarity algorithms such as Smith Waterman ( SW ) .
The reported norms are of greater scope and precision than previously available and have utility in a range of clinical and research settings.
The reported number of registered leprosy patients worldwide declined with the introduction of multidrug therapy.
The reported prevalence estimates were interpolated between @number@ and @number@ years.
The reported prevalence of diagnosed diabetes was @percent@ with @percent@ of NHs treating residents with insulin.
The reported studies included more recent studies and / or studies with relevant scientific characteristics.
The report emphasizes the significance of the aging population and implications for cancer care.
The reporting error in this type of measure can have implications on the robustness of frailty findings.
The reporting of dementia on death certificates was poor in these @number@ studies , ranging from @number@.2%-41.8%.
The representation of social interaction in episodic memory is a critical factor for the successful navigation of social relationships.
The representations we have of old age are sometimes far from reality.
The reproducibility of the results was also evaluated.
The reproducibility was evaluated by administering the PASE questionnaire during two occasions separated by @number@ days.
The reproductive outcomes of the egg provider and recipient can thus be compared to quantify the significance of oocyte quality.
The reproductive sequelae of cancer treatments may provide an important model of accelerated ovarian aging.
The reprogramming process may be influenced by external and internal factors that result in improper epigenetic changes in germ cells.
The required model parameters were estimated based on available results of human and experimental animal studies.
The required potentialities are realized mostly through enzymatic catalysis.
The requirement for alternative splicing during adipogenesis is poorly understood.
The requirement for individual informed consent for a quality improvement project made the inclusion more prone to selection bias.
The requirement for p38MAPK in hyperglycemia-induced senescence was determined using inhibition and overexpression studies.
There remains a clear need to optimize the use of anticoagulant drugs in these patients , especially at full anticoagulant dose.
There remains a disconnection between the nodes and modes of practice of stroke neurologists and cognitive physicians.
There remains a lack of information regarding the effectiveness of exercise training on individuals with DS post-stroke.
There remains , however , an unmet need to improve outcomes for AHF patients.
There remains interest in 2DG as a CRM but at lower doses.
There remains limited research on cardiovascular disease ( CVD ) risk factors in Puerto Rican adults.
The rescaled r² of the model was @number@
The research activity of each institute and their international collaboration is briefly described with examples focused on recent publications in the field of biogerontology.
The research aim was to determine the overall morbidity trends in Croatian elderly population.
The research committee of the CdLS Foundation organizes the meeting , reviews and accepts abstracts and subsequently disseminates the information to the families.
The researchers collected baseline data at admission and outcomes on the day of discharge , one month after and three months after the discharge.
The research focus over the selected period was greatly directed towards medical considerations , especially vascular conditions and renal dialysis.
The research has mainly focused on the graph characterization of the resting-state / default network , and its potential for clinical application.
The research involved @number@ men aged 50-75 years.
The research material consisted of models of @number@ men and @number@ women.
The Research Program at PCA became an important part of this effort by providing multiple types of supports to PCA staff and other stakeholders.
The research project was approved by the Research Ethics Committee.
The Research Resource Network as well as the Brain Donation System of patients with Parkinson disease started in the National Center for Neurology and Psychiatry.
The research summarized here has pursued the goal of determining the physiological and clinical significance of biological grounding.
The research tested the concepts involved with age differences in updating situation model.
The research to date suggests that oxidative stress and mitochondrial DNA deletion ( mtDNA ) play a major role in pathophysiology of ARHL.
The research tool was a questionnaire divided into @number@ sections.
The research was aimed at studying molecular genetics basis of human longevity.
The research was approved by the Research Ethics Committee of the Faculty of Medical Sciences of the State University of Campinas ( UNICAMP ) .
The research was completed in the United States in @number@
The research was executed on @number@ male patients aged 35-92 years with various polyorgan pathology in a compensation stage.
The resected sample revealed transmural gangrenous necrosis of the colon and rectum.
There seems to be inconsistent evidence for a protective role of vitamin D supplementation alone on bone mass.
The reservation about offering RES to the elderly is multifactorial with their advanced age and comorbidities being the primary reason.
There should be more attention to careful safety monitoring and adverse event reporting.
The Resident Classification Scale measured functional dependency.
The residents ' adultery and homosexuality frames show that they mostly retain dominant values from their youth , often combining them with contemporary dominant values.
The residents ' adultery and homosexuality frames show that they mostly retain dominant values from their youth , often combining them with contemporary dominant values.
The residents of the ethnic clusters of public housing reported poorer health , were more reliant on government resources , and experienced greater acculturative hassles.
The residents receiving 2MCGA had lower baseline Mini-Mental State Examination scores , and higher CDR.
The residents suffering from malnutrition had the poorest psychological well-being.
The residual collagen fraction was further extracted by collagenase digestion.
The residual deficit in isometric and concentric plantar flexor torques in healthy older adults may involve reduced muscle quality.
The residual septum was removed by gastroscopic electrocauterization.
The resilience indicators ( variance , temporal autocorrelation , and cross-correlation ) were calculated using multilevel models.
The resilience measure comprised three sub-scales of social support , emotional regulation and problem solving.
The Resilience Scale was specifically developed to measure personality characteristics of resilience in older adults.
The resin cement / Y-TZP interface was less susceptible to failures , owing to Y-TZP surface treatments.
The resolution of the inflammatory response is highly regulated by the timely biosynthesis of a number of endogenous lipid mediators.
The resource-modulation hypothesis assumes that aging-related losses of neurochemical and structural brain resources modulate the extent to which genetic variations affect cognitive functioning.
The respective contribution of occupational and behavioural factors to social disparities in all-cause mortality has been studied very seldom.
The respective figures for Groups @number@ and @number@ were @percent@ and @percent@ ( p = 0.004 ) .
The respective homologs mainly represent NADH dehydrogenases , ATP synthases , cytochrome oxidases , Ras GTPases and ribosomal proteins.
The respective RRs ( @percent@ CI ) were @number@ ( @number@.049-0.999 ) , @number@ ( @number@.031-0.554 ) , and @number@ ( @number@.100- @number@ ) .
The respective strengths and limitations of each species relative to mitochondrial studies are explored.
The respective values for E7-testing as a triage method to colposcopy ranged from @number@.0-100.0% , @number@.86-26.08% and @number@.83-5.93.
The respiratory system is one of the primary interfaces between the body and the external environment.
The respirophasic variation of the IVC diameter was increased with advancing age ( r = @number@ p = @number@ ) .
The respondents answered questions regarding their socioeconomic and demographic information , health and social situations , cognitive impairment , depressive symptoms and family satisfaction.
The respondents completed measures of human values , drinking frequency and typical drinking quantity.
The respondents ' demographic and health characteristics and depressive symptoms at baseline were included as control variables.
The respondents ' profile variables were organized in Andersen's Model and community healthcare resource factors were added.
The respondents saw themselves as having a good old age.
The response criterion of younger participants was always conservative , whereas older participants only showed liberal criteria in front of faces with emotional expressions.
The response of ADH to the infusion of hypertonic saline divides SIADH into @number@ different types.
The response of neoadjuvant chemotherapy was comprehensively evaluated based on RECIST @number@ and Miller-Payne grading system.
The response of skeletal muscle to unaccustomed eccentric exercise has been studied widely , yet it is incompletely understood.
The response of the CONER nanoprobe was dependent on various parameters such as reaction time and nanoparticle concentration.
The response rate for survival was @percent@.
The response rate is @percent@.
The response rate of was @percent@.
The response rates were @percent@ ( n = 2511 ) and @percent@ ( n = 1637 ) , respectively.
The response rate to postal invitation was @percent@ ( 445 / 545 ) , with @number@ patients responding as \ "interested. \ "
The response rate was approximately @percent@.
The response rate was @percent@ and all analyses were weighted to account for the sampling design.
The response rate was @percent@ and @number@ respondents did not meet the inclusion criteria.
The responses before and after use of the aid were compared for each participant.
The responses of the models , in general , were within the cadaveric response corridors.
The response times and the response time variability decreased with age in both groups and were significantly greater in ADHD than in controls.
The response to amyloid deposition is comparatively smaller.
The response to catecholamines was similar between different age groups.
The response to therapy was evaluated by two independent dermatologists , with standardized photographs taken @number@ weeks and @number@ month after the laser treatment.
The response to therapy was evaluated by two independent dermatologists with standardized photographs taken @number@ weeks and @number@ month after the laser treatment.
The response variable was the loss of TASM defined as the lowest sex-specific 15th percentile of the cohort distribution of percentage of change in TASM.
The responsiveness of VDR may be affected by gene variants , such as the FokI polymorphism ( rs2228570 ) .
The rest eA correlated with ultrasound-measured brachial artery area ( r = 0.77 , P < 0.001 ) .
The resting electroencephalogram ( EEG ) provides non-invasive spectral markers of brain function and development.
The resting-state fluctuation amplitude ( RSFA ) in the fMRI signal ( rsfMRI ) has been proposed as an index of vascular reactivity.
The rest of phase @number@ and phase @number@ have not yet been addressed.
The rest of the carriers were apparently healthy ( asymptomatic carriers ) and were compared with the noncarriers.
The rest of the endogenous ERPs parameters ( P300 amplitude , N200 amplitude ) were not significantly correlated with the MRI variables.
The restoration of the expression level of some prolongevity genes after fir extract treatment was shown in old cells.
The restricted and more recent evolutionary appearance of pol ν ( in comparison to pol θ ) supports such a specialized role.
The resultant animals were examined for hematologic parameters , clinical symptoms , and responsiveness to human FVIII ( hFVIII ) .
The resultant deficiencies of the skeletal foundation contribute to the stigmata of the aging face.
The resultant functional maturation curve accounted for @percent@ of the sample variance and followed a nonlinear asymptotic growth curve shape.
The resultant report should include all of this information.
The result can be seen as the emergence of a ' late modern ' social imaginary deemed as the fourth age.
The result could be useful to establish normal volumes of PCA and OFC of each age group to assess neurological disorders that affect olfactory function.
The result from the present study revealed significant age-associated declines in Aβ42 levels but not in Aβ40 and phosphorylated tau levels.
The result indicated that old people in Hong Kong had an overall positive attitude toward technology.
The result indicates that HC is not protective for metabolic risk factors in males.
The resulting 21-item questionnaire was administered to patients and families in @number@ adult ICUs.
The resulting age-at-death distributions were then compared with age-at-death distributions for the two populations constructed using traditional aging methods.
The resulting areas under the curve ( AUCs ) were @number@ and @number@ respectively.
The resulting assessment provides valuable information on the functional status of older adult patients with cancer.
The resulting atlas can be used in a Bayesian framework to segment the brainstem structures in novel scans.
The resulting better homeostasis improves life span and quality of organism's life.
The resulting BVL / year curves were compared between the two cohorts.
The resulting category of all-diseases is examined as a helpful tool to better understand the relationship between mortality and age.
The resulting cerebral small vessel disease and heart failure may contribute to early cognitive decline and ( vascular ) dementia.
The resulting changes in dentognathic size and shape are substantial and need to be taken into account in comparative taxonomic analyses of isolated hominin mandibles.
The resulting chaos impedes development of consensus 25 ( OH ) D values to define stages of vitamin D status.
The resulting communication , technology , education , and emphasis can improve the quality of life for the people served.
The resulting dataset was analyzed using multiple conditional logistic regression.
The resulting data was processed using previously designed techniques including wavelet denoising , spline filtering , and fuzzy means segmentation.
The resulting decrease of ADMA would in turn enhance nitric oxide ( NO ) production.
The resulting definition establishes mandatory criteria and exclusion criteria necessary for classifying a case of CKDnT.
The resulting distribution characteristics DC-potential compared with the average values for the corresponding normative age period.
The resulting earlobes have undisturbed free borders.
The resulting estimates were then regressed on each sleep measure , adjusting for sociodemographics , health behaviors , and comorbidities.
The resulting evidence was discussed in a round table with an interdisciplinary panel of ten European experts.
The resulting foot and nail care needs create opportunities for CFCN to promote health and prevent adverse outcomes such as infection and limb loss.
The resulting identification function exhibited a gradual slope from male to female voice categories.
The resulting impaired function increases the risk of aspiration and choking.
The resulting mean correlation coefficient ( standard deviation ) was @number@ ( @number@ ) .
The resulting model provides new insight into the mechanics of AF and a platform for exploring future therapies.
The resulting multilevel hierarchical model can merge detailed results on different subsystems into a coherent understanding of whole-body glucose homeostasis.
The resulting muscle tissue displacement can be quantified , in a single plane , using ultrasound ( US ) imaging.
The resulting network consists of @number@ proteins involved in @number@ interactions.
The resulting nuclear FOXO increases expression of target genes , including mitochondrial superoxide dismutase.
The resulting @number@ fingerprinting SNPs represent a significant decrease in complexity and the number of markers used for genetic data labelling and tracking.
The resulting oncogenic clonal expansions then increase the odds of further cancer progression.
The resulting polygenic hazard score is an assessment of individual genetic risk.
The resulting samples can be utilized for various downstream analyses , including mass spectrometry-based PTM profiling.
The resulting set of @number@ segmentations was analyzed in a common anatomical space to quantify similarity and identify areas of agreement.
The resulting time , accuracy , and cluster parameters behaved plausibly in each of the @number@ data sets.
The resulting transient increase in cytoplasmic free calcium concentration is a critical trigger for the initiation of such vital responses as muscle contraction and transcription.
The resulting tumours displayed strong histological similarity with human prostate cancer.
The resulting underestimation of body mass index was @number@ ( @number@.3-2.0 ) units.
The resulting ' vicious circle ' of mitochondrial mutation has been proposed to underlie aging and its associated degenerative diseases.
The result is accumulation of insidious damage , increasing disease risk.
The result is a high rate of non-adherence with medical care and therapy , resulting in poor outcomes.
The result is an emerging , vulnerable population , and the question is how to best care for them.
The result is arising of individual heterogeneity , in which unbalanced allocation of resources ends with the death from reproductive overload.
The result is inappropriate patient care.
The result needs to be confirmed in a larger study.
The result of the study will give evidence for best practice for continence care in nursing homes , and organizational advice concerning implementation strategies.
The result of this ageing process leads to an increase in pulse wave velocity and widening of pulse pressure.
The result of this signaling is mitochondrial protection.
The result of this study suggests that disc degeneration appears to be a systemic phenomenon.
The result of this training is that knowledge , skills and attitude in care of the elderly improved significantly.
The result remained unchanged after adjustment for age , sex , apolipoprotein E E4 presence , and leukoaraiosis.
The results allowed us to identify the specific brain regions that first fail to encode spatial information into an episodic representation during the adult lifespan.
The results allow making a conclusion that these disorders could not be explained either by radiation effects or by PTSD but connected with cerebrovascular pathology.
The results allow the conclusion to be drawn that studies use several different instruments , most of them not validated.
The results also demonstrate that the method can detect atrophy patterns in the brainstem structures that have been previously described in the literature.
The results also have implications for our understanding of demographic processes during the second urban transition in developing countries.
The results also highlight the importance of treating underlying health impairments and preventing the transition from FOF to activity restriction.
The results also hold when controlling for mortality-related expenditures.
The results also indicated that older adults required explicit retrieval of contextual information before making FOK judgments in order to make accurate FOK predictions.
The results also indicated that the tensile properties of HDPE / HA nano-composite increased with increasing the HA content except fracture strain decreased.
The results also indicate how advances in nursing science can facilitate future research in the modeling of trajectories and transitions in the dementia care context.
The results also point to a potential dissociation between age-related changes in subjective valence and in positive word use.
The results also provide some evidence of convergent validity for the recently developed GSIS.
The results also provide the first report of the foot's center of mass trajectory during the swing phase of the gait cycle.
The results also reveal negligible or modest contributions of the biomarkers to educational disparities in the health outcomes.
The results also showed that as the vaccination coverage rate increased @percent@ , a decrease of @percent@ was observed in the hospitalization rate.
The results also show no interaction between gender and seasonal birth date ( p < 0.01 ) .
The results also show that a large and accurately staged sleep dataset is of great importance when developing automatic sleep staging methods.
The results also suggest caution in using SRH to capture age-related health changes in the older population.
The results also suggest that , at least early in the course , cognitive decline may be driven in large part by metabolic processes.
The results also suggest that grammatical reasoning and episodic memory are particularly vulnerable to age-related decline.
The results also suggest that one component of an optimal therapy for Alzheimer's disease may be a TrkA inhibitor.
The results also suggest that persons with MCI benefit from the cognitive intervention in the follow-up data.
The results also suggest that the direction of effect is complex.
The results also suggest that the SVTs are not equally sensitive to cognitive dysfunction.
The results also suggest the potential of NanoOSE as a candidate new phytotherapeutic agent on the management of BPH.
The results and complications were categorized based on the type of surgery performed , and the Dindo-Clavien scale.
The results and conclusion are based on experimental and clinical observations coupled with a search of the literature.
The results and implications for further research and practice are discussed.
The results and outcomes of interest were detailed in a descriptive report.
The results appear gradually over time and are maintained for at least @number@ months ' post-treatment.
The results are comparable with earlier studies and indicate that the Norwegian versions can be used in daily clinic and in research.
The results are compared to the non-elderly residents of these two communities for purposes of contrast.
The results are compared to the non-elderly residents of these two communities for purposes of contrast.
The results are compared with those from in vitro studies.
The results are considered in the context of theories of laterality inclusive of lateralized differences in postural dynamics.
The results are consistent with an earlier hypothesis of preferential weakening of intrinsic hand muscles with age.
The results are consistent with low body temperature as a biomarker for longevity.
The results are consistent with sympathetic activation of β-receptor coronary vasodilation in humans , as has been demonstrated in animals.
The results are consistent with the idea of an adjustment of mental resources that could help compensating potential deficiencies in peripheral and central auditory processing.
The results are consistent with the idea that personal episodes occurring near the boundaries of extended lifetime periods receive preferential processing that enhances long-term memory.
The results are consistent with the view that memory functioning in aging is accompanied by a shift from automatic to controlled forms of processing.
The results are discussed from the perspective of sociohistorical context and public policy.
The results are discussed in light of contemporary models of attention function.
The results are discussed in relation to disability , women's health , and social support issues , including recommendations for health professionals and care providers.
The results are discussed in relation to suggestions for interventions aimed at women aged 18-34.
The results are discussed in relation to the elderly patient-centred paradigm and in order to counterbalance still present ageist practices.
The results are discussed in terms of age-related differences and according to the spatial cognition framework.
The results are discussed in terms of cognitive plasticity in older adults.
The results are discussed in terms of current models of cognitive control.
The results are discussed in terms of the measures used and the implications for practice.
The results are discussed in the context of the evolutionary emergence of menopause and extensive post-reproductive life-span.
The results are discussed in the light of successful aging.
The results are discussed in the light of the challenges of active and satisfactory aging.
The results are discussed in the view of the hypothesis that considers submovements to be the building blocks of a graphical movement.
The results are discussed with a particular focus on the role of working memory retaining the internal representations of sequences being learned.
The results are interpreted as supporting use of much larger SNP sets in common disorders where effects are small.
The results are interpreted in terms of noisier sensory information and increased uncertainty in relation to deficits in the magnocellular pathway.
The results are interpreted within the framework of age differences in hippocampal structure and function.
The results are of applicable value to aortic valve repair.
The results are partially explained by the tasks differential difficulty , and are discussed within the frame of Simulation theory.
The results are particularly significant given recent increases in maternal ages in many societies and the potential consequences for offspring health and fitness.
The results are promising for the possibility to overcome constraints of bilateral hand movements by long-term practice.
The results are robust ; controlling for current characteristics does not change effect sizes and significance.
The results are summarized according to the multidimensional approach of quality of life considering the bio-psycho-social model of health.
The results are then compared to age- and IQ-matched postmenopausal women not taking HT.
The results are useful for community agencies considering implementing EnhanceFitness for their populations.
The results can be used in optimization of screening , prevention and treatment strategies of chronic diseases among U.S. elderly population.
The results can help the clinicians focus on the aspects that mainly influence the vertebral cortex fracture risk factor.
The results confirmed our hypothesis , showing age-related effects of leg muscles fatigue in both gait conditions.
The results confirmed the four-factor structure reported in studies on non-treatment-seeking individuals.
The results confirm inter-population variation does exist.
The results confirm previous findings on ageing effects and demonstrate the complete absence of correlation between MPOD and the subject's YB chromatic thresholds.
The results confirm previous results of a four factor structure.
The results confirm that NIRS is suitable for measurement of blood oxygenation changes in frontal brain areas that are associated with all four cognitive tasks.
The results confirm the importance of the symbolic dimension of personal experience in managing care and seeking medical treatment.
The results consistently showed widespread and regionally variable nonlinear decreases in cortical volume and thickness and comparably smaller steady decreases in surface area.
The results correlate with the corresponding data obtained by dynamic contact angle measurements according to Wilhelmy.
The results corroborate evidence that low socioeconomic status is related to higher IL-6 plasma levels in elderly women.
The results corroborate previous evidence regarding the relative importance of attenuation and justification bias in self-reported health measures.
The results could help to develop a conceptual framework to predict the likelihood of falls discussion.
The results demonstrate a link between aging , dopaminergic function and dedifferentiation in the hippocampus.
The results demonstrate a progressive cognitive decline and morphometric changes in the striatum and hippocampus in a transgenic HD monkey.
The results demonstrated a low vitamin D status in @percent@ of men and @percent@ of women.
The results demonstrated a priming effect in the young and elderly participants , but only for the primes presented without the visual mask.
The results demonstrated that all groups benefited from WM training , as expected.
The results demonstrated that ARE possessed the antioxidant activity and was effective against D-galactose-induced oxidative stress.
The results demonstrated that elderly remain able to adapt FNC to task demands.
The results demonstrate that after training , patients with MCI improve significantly both in overall cognition and overall self-ratings.
The results demonstrate that a relatively short-term Bikram yoga practice might significantly improve vascular endothelial function in middle-aged and older adults.
The results demonstrate that both kits are statistically similar in performance.
The results demonstrate that conceptions of even such fundamental domains as time can differ dramatically across cultures.
The results demonstrate that increases in age can produce significant improvements in the visual ability to perceive the magnitude of exocentric distances.
The results demonstrate that motor and cognitive functions both undergo a period of accelerated decline in the last few years of life.
The results demonstrate that temporal order memory for fixed and random sequences is impaired in nondemented older adults , particularly when temporal interference is high.
The results demonstrate the interaction between social knowledge , situational social goals , and chronic socioemotional goals in determining age differences in social information processing.
The results demonstrate the need for an educational program for CHW , in the area of gerontology.
The results demonstrate the possible wide applicability of UV-A sterilization.
The results demonstrate the system's ability to reliably detect changes related to specific and integrated aspects of balance , gaze , and cognitive performance.
The results did not change after adjustment for hypertension , obesity , diabetes , or disorders of lipid metabolism at baseline.
The results did not vary for men and women or by self-employment status.
The results discussed in this paper suggest a well-selected antibody panel should be used as an additional test for the identification of early AD.
The results emphasize the importance of defining the requisite bioavailability of each micronutrient and the influence of the dosage form that provides it.
The results emphasize the importance of providing more support for these aspects of self-care to such older adults.
The results emphasize the need for considering sociocultural contexts in which psychological resources are experienced in order to understand linkages to physical health.
The results evaluated by clinicians were very much in correlation with those of patients.
The results expanded our knowledge on the mechanical property of the elderly's skeletal muscle and its relationship with intensity of active contraction.
The results extend the concept of CR to VCI.
The results failed to provide evidence that a multifactorial falls prevention program was cost-effective.
The results for Austrian participants are presented in this article.
The results for the younger subjects revealed gap thresholds and recovery rates that were comparable with previous studies of auditory neural gap coding.
The results found are inconclusive.
The results from each study are combined using meta-analysis.
The results from meso-models are applied to identify the parameters of a phenomenological constitutive formulation that interprets the overall human fat pad tissue mechanics.
The results from our survey indicate a marked difference in the preference for a single room between @number@ and @number@
The results from randomised controlled clinical trials on treatment of these risk factors are not conclusive for the effect on cognitive decline and dementia.
The results from studies with intranasal insulin are also encouraging.
The results from the first large randomized controlled trials show no differences between old and fresh RBCs.
The results from the meta-analysis show that many of these variants are associated with survival to these extreme ages in other studies.
The results from this study demonstrate that REMS is superior in predicting the mortality of these patients compared to RAPS and MEWS.
The results from this study indicate that animal age is a significant factor that influences the prevalence of STEC in cattle.
The results from this study present strong evidence that there is a change in the relationship between the two signals with aging.
The results further support the consideration of Ov-CPI-2 as a leading target for an anti-L3 vaccine.
The results give some support that rapidly forward-rotating shift systems are more ' age-friendly ' than backward-rotating shift systems.
The results have also showed that many items in SGRQ revealed age or severity related DIF.
The results have implications not only for elucidation of the aging process , but also for reference in dementia screening.
The results have important implications for the understanding of older adults ' PM commission errors and the processes involved in these errors.
The results have potential application in orthopaedic medical therapy.
The results have several important implications related to cancer survivorship among older adults.
The results have to be interpreted with care ; larger confirmatory trials are necessary to validate the effects.
The results highlighted that barrier function recovery and overall kinetics of gene expression were delayed following stripping in aged skin.
The results highlight the complex role of the e4 allele in genetic susceptibility to health span.
The results highlight the impact of task context on postural stability during standing reach in young and older adults.
The results highlight the need to focus on stroke risk in individuals even with MCI.
The results highlight the promise and utility of behavioral economic tools for assessing trait and state influences on cognitive motivation.
The result showed that muscle spindle composition and distribution were alike in young and adult masseter.
The result shows that specific ratio of T lymphocyte subsets CD3 and CD4 and the content of serum IgG significantly increase after pharmacy of patients.
The results , if confirmed , should inform air-quality recommendations in light of a potentially susceptible subgroup.
The results implicate new genetic pathways involved in LRO biology , aging related physiology , and potentially human diseases of the LRO.
The results implicate stimulus categorization more than response selection as an important locus of inefficient dual-task processing , particularly for older adults.
The results imply that EGb protects against chondrocyte degeneration by inhibiting JNK activation and inducing ubiquitination-dependent c-Jun degradation.
The results imply that interventions to prevent inequalities in childhood obesity should begin in pre-school years.
The results imply that long-term effect of childhood deprivation on health may be stronger among women in Korean society.
The results indicate a trend for improvements in life expectancy without cognitive impairment over time in São Paulo.
The results indicated a significant association between the number of sites and severity of pain and the prevalence of depression in the Korean elderly.
The results indicated increased sensitivity of the longitudinal approach as well as qualitative differences.
The results indicated that age differences in the Stroop effect were influenced by visual function and cognitive load.
The results indicated that AGE-α-synuclein aggregates into smaller globular-like aggregates compared to fibrils formed with native α-synuclein.
The results indicated that , balance of oxidant and antioxidant systems in lymphocytes shifts in favor of accelerated oxidative damage during aging.
The results indicated that both age groups showed the same degree of retrieval-induced forgetting of the lists.
The results indicated that health promotion amenities were available , but with some limitations.
The results indicated that marks on the life story assignment predicted marks on an exam about basic course concepts.
The results indicated that memory and executive performance were consistently and significantly correlated in older but not in younger adults.
The results indicated that migrant social networks act as pathways linking immigrant women with employment opportunities in nursing homes.
The results indicated that most drivers were satisfied with the navigation technology and found the directions it provided to be clear.
The results indicated that @number@ ( @percent@ ) of the @number@ fungal strains produced CPA.
The results indicated that older adults in the higher physical activity group exhibited shorter response times , independent of the working memory load.
The results indicated that on average , an estimated @number@ older adults were treated in emergency departments each year for nonfatal pedestrian injuries.
The results indicated that the APOEε2 and APOEε4 alleles produced convergent effects in the right AFC network but divergent effects in the left AFC network.
The results indicated that the battery was sensitive to group differences in FC.
The results indicated that the bone marrow perfusion function interacts with bone modeling and could have a long term effect on BMD.
The results indicated that the event memory was retained over lengthier delays relative to the location memory , despite superior encoding of location information.
The results indicated that the three TPF50 components had a synergistic effect in reducing CPD and PC , but not 8OHdG.
The results indicated that V UCM were not significantly different for the older and younger groups.
The results indicate HT-related modulations in both FCAs and interhemispheric interaction.
The results indicate nutrient restriction causes lower apoptotic and higher autophagy rates in HCT @number@ spheroids.
The results indicate similar discriminative accuracy for incident dementia based on the CAMCOG total , memory subscale and composite scores.
The results indicate similar training progress and larger improvements in the executive control task for both training groups when compared to the passive control group.
The results indicate that < 1% of variance in plasma cortisol is accounted for by genetic variation in a single region of chromosome @number@
The results indicate that age has a negative impact on the laboratory time-based task and a positive impact on the naturalistic task.
The results indicate that being in a memory-testing context affects older adults ' self-perception by making them feel older.
The results indicate that distensibility and moisture content of the lower labial mucosa decrease with age.
The results indicate that early-life and late-life migrant women spend more years with Performance-Oriented Mobility Assessment limitations than U.S.-born women.
The results indicate that employer-provided pensions have substantial and significant incentive effects on retirement behaviour.
The results indicate that for old people , their distribution will be influenced by the environmental factor to some extent.
The results indicate that group-referencing increased recognition memory performance compared to the familiarity judgements for both young and older groups.
The results indicate that heteroplasmy in HVS-I is relatively common and occurs in a broad spectrum of sites.
The results indicate that in contrast to healthy subjects , migraineurs show a lack of thinning in the insula by age.
The results indicate that interjoint coordination in young adults leads to less hand path variability compared to older adults.
The results indicate that isoflurane induced hippocampal mitochondrial dysfunction and activated CaN , which subsequently lead to the putative activation of NF-κB.
The results indicate that low-level heteroplasmies are transmitted and maintained within families until extreme age.
The results indicate that OPTN mutations causing ALS are rare , especially in mainly Caucasian ALS subjects.
The results indicate that pathways to adulthood are influenced by social reproduction factors in a country with high levels of welfare benefits as well.
The results indicate that @percent@ of adults with an intellectual disability demonstrate aging conditions.
The results indicate that repeatable data can be obtained with high within-subject correlation.
The results indicate that specific CpGs in SCGN and KLF14 can be used as potential epigenetic markers to estimate age using saliva and blood specimens.
The results indicate that systematic differences in TTA estimates can be a reasonable explanation for the effect of speed on gap acceptance.
The results indicate that the contribution of butter alone to the exposure to CML and HMF is very low.
The results indicate that the highly automated swallowing network retains its functionality with age.
The results indicate that the memo-BNT could be used in clinical settings especially to differentiate between normal aging and mild AD.
The results indicate that the nighttime exposure of tauopathy / AD model Drosophila flies to dim light disrupted CR and sleep-wake behavior and promoted neurodegeneration.
The results indicate that the oxidation favors carboxylic acid functionalization , but significantly less than other studies performed under nonatmospheric conditions.
The results indicate that the proposed simulator reproduces realistic patient-specific patterns of longitudinal brain change for the given populations.
The results indicate that the relative importance of different factors vary as a function of assessment context , with conceptual as well as applied implications.
The results indicate that translocase-based mechanisms enable DNA synthesis to continue past ICLs and that these lesions are not always absolute blocks to replication.
The results indicate that when the objective is increasing power through isoinertial training , P machines at HS appear to be the most effective alternative.
The results indicate , that WPSS reflects the listening effort related factors needed to solve an auditory task.
The results indicate that young adults ( 18-25 years ) achieve an optimal balance between anticipation and execution.
The results indicate the declines of muscle mass , force and power production capacity with aging.
The results likewise suggest there may be different psychosocial profiles associated with each adult status group.
The results mainly confirmed the typical effects of a visual search task.
The results may be used to guide experiments with two-photon bleaching.
The results may have implication for nano-based local delivery of therapeutic agents in skin.
The results may have implications for future therapeutic trials involving anti-inflammatory agents.
The results may provide insight into the strong association between behavioral attributes of food consumption and the development of obesity.
The results mirror the temporal sequence and magnitude of Aβ and Tau changes in the CSF of patients with sporadic and dominantly inherited AD.
The results obtained from AL-fed rats showed that diminished FoxO6 activity during aging was caused by FoxO6 phosphorylation , which disabled its transcriptional activity.
The results obtained from granulosa cell lines and animal models may not fully extrapolate to humans.
The results obtained imply that the development of the age-related cataracts might originate from the metabolic dysfunction of the lens epithelial cells.
The results obtained provide insight of the potential therapeutic effects of C. rotundus in the contexts of analgesia and UV-induced photoaging.
The results obtained showed a significant decrease of serum iron , ferritin , and transferrin concentrations in patients compared with the control subjects.
The results obtained suggest that BDNF operates in the development , maturation , maintenance and plasticity of human brainstem precerebellar neuronal systems.
The results obtained were further substantiated using Antonovsky's ( @number@ ) theory of salutogenesis.
The results of a fixation-free incisional hernia repair carried out in elderly patients using a tentacle-shaped implant are reported herewith.
The results of all the motor tests performed were inversely correlated with age.
The results of analysis by living-cell fluorescence imaging and flow cytometry were consistent with those of the cell proliferation and apoptosis assays.
The results of analysis suggest that the variability depends on both the level of maturation of the participants as well as the task complexity.
The results of a variety of non-redundant analyses across both studies revealed a dimensional latent structure for ODD symptoms among both children and adults.
The results of bioinformatic analyses were consistent with RGFP963 inducing a transcriptional program that enhances synaptic efficacy.
The results of both examinations revealed a higher percentage of skin characteristics typical for photoageing in outdoor workers compared to the general population.
The results of CDS for the study group were running at high level and were dependent on the marital status and age.
The results of cell cycle analysis indicated that the cell cycle and proliferation progressed normally up to 48h post-transfection.
The results of cluster analyses show the further differences in taxonomies of personality traits at different period of life.
The results of cognitive performance have been compared with a control group consisting of @number@ subjects with no cognitive training.
The results of cutometric measurements for R7 showed the improvement in skin elasticity in case of all treatment methods.
The results of diagnostic studies often were not understood by older patients.
The results of epidemiological studies , and intervention trials in animal models suggest that diets rich in phytochemicals can enhance neuroplasticity and resistance to neurodegeneration.
The results of evaluation of gene expression , GATA-3 in lymphocytes showed the increased expression of GATA-3 in elderly people in comparison with the young.
The results of Experiment @number@ replicated those of Experiment @number@
The results of Experiment @number@ revealed that a repeated study-test procedure may to some extent facilitate the free recalling of bizarre images in older adults.
The results of Experiment @number@ show again less head motion during several task conditions than during rest.
The results offer a preliminary methylome map that enhances our understanding of alcohol-induced damages and offers new targets for alcohol injury research.
The results of Generalized estimating equations and mixed effects models showed nearly identical sets of factors.
The results of genome-wide association studies ( GWAS ) are often positioned as discoveries of unconditional risk alleles of complex health traits.
The results of infrared spectra , The presence of food components may alter the colloidal aspects and toxicity of nanoparticles ( NPs ) .
The results of longitudinal ( from @number@ to @number@ ) study of students are presented.
The results of moderated regression analyses demonstrated that gender interacted only on the relationship between positive social interaction support and tangible support with life satisfaction.
The results of multiple assays showed that this cell death was mediated by apoptosis.
The results of multivariate analysis showed that eGFR was negatively correlated with the level of AIX ( P < @number@ ) .
The results of nurses ' observations may be used in triage contributing to the diagnostic process by selecting patients requiring further neuropsychological assessment.
The results of observational studies support a dose-dependent neuroprotective relationship between physical exercise and cognitive performance in older adults.
The results of our recent studies on autophagic death of adult hippocampal neural stem ( HCN ) cells are also discussed.
The results of our study demonstrate regional age-related changes in the prefrontal white matter tracts of the human brain.
The results of our study indicate gender differences for arterial stiffness and arterial age in smokers.
The results of our study indicate that there is insufficient knowledge about the everyday life of older people in Japan in gerontological research.
The results of our study provide new insight into the signaling pathways involved in HCA2 activation.
The results of our study suggest that aerobic exercise increases BDNF plasma levels in patients with AD and healthy controls.
The results of our study suggest the association of vitamin D status with post-partum thyroiditis and L-thyroxine treatment of this disorder.
The results of our systematic review indicate that the Klotho KL-VS variant is associated with healthy aging.
The results of palmomental reflex were recorded.
The results of power spectral analysis of the EMG activity of the left erector spinae muscle were compared in both age groups and sexes.
The results of Rasch model analysis can highlight aspects for scale improvement , such as gap , duplicate items or scale responses.
The results of RCT with antidepressants are inconsistent.
The results of series of clinical trials using mTOR inhibitors in HCC treatment will emerge in the near future.
The results of structure-activity relationships studies concluded that a hydroxyl oxime moiety plays an important role in ligand-enzyme affinity through hydrogen bonding.
The results of such analyses could be used in work space design and in fall-prevention instructional materials , for both the home and work place.
The results of such analyses may highlight attractive targets for treating or preventing smoking-related health effects.
The results of that analysis show that all displays tend to yellow over time , but that they do so together.
The results of the binary logistical regression analysis indicated that age and history of stroke were associated with MCI in men.
The results of the enquiry confirmed the suitability of the parameters selected for the evaluation of the aging process of the cervical spine.
The results of the experiment offered two practical examples of how the model could be used to investigate the temporal distribution of autobiographical memories.
The results of the few intervention trials reporting the use of pro / prebiotics in clinical conditions typical of the elderly will be critically reviewed.
The results of the logistic regression established that age was the single most significant factor in enthesopathy formation ( P > @number@ ) .
The results of the multilevel regression analyses are reported as odd ratios.
The results of the multivariate analysis showed that age ( P = @number@ OR = @number@ ) was associated with worse performance on gait speed.
The results of the polarized light microscopy , small-angle X-ray scattering and rheology analysis indicated the presence of typical LCS structures with lamellar arrangement.
The results of the present study are invaluable in prognostication and healthcare decision-making for this group of frail older patients.
The results of the present study indicated that the low power He-Ne laser might decrease shortening rate of telomere and delay the aging of cells.
The results of the present study provide evidence of long-lasting effects in spatial learning and memory after early exposure to BDE-209.
The results of the present study show , for the first time , that there is an increase of IL-22 in healthy centenarians.
The results of the present study suggest a relationship between subtle language deficits and early stages of basal ganglia dysfunction.
The results of the present study suggest that remote MCI detection through VR applications can be feasible.
The results of the present study suggest that there is no difference in the characteristics of visuomotor control for appropriate obstacle crossing based on age.
The results of therapy remain unsatisfactory , and progress has been relatively slow.
The results of the saccadic eye tests of the different groups were compared.
The results of the screening study were used to develop four model borate glass compositions for further study.
The results of these analyses are considered here , along with their potential application.
The results of these analyses converged to suggest that reinstatement did not differ according to age.
The results of these medication reviews were sent to the community pharmacist to be discussed with the patient's general practitioner ( GP ) .
The results of these procedures are therefore sometimes not optimal and do not achieve a natural youthful appearance.
The results of the study also suggest that the interlocutor's interventions become less necessary with the aging process.
The results of the word-stem completion task showed similar implicit memory in the three groups.
The results of this investigation suggest that mitoQ may have anti-immunosenescent potential.
The results of this observational study suggest that donor leukocyte telomere length may have a role in long-term posttransplant survival.
The results of this phase @number@ study support further clinical development of cadazolid.
The results of this pilot study demonstrated that pioglitazone exhibited cognitive and functional improvements , and stabilization of the disease in diabetic patients with AD.
The results of this review highlight disparities for YLHIV and the need for interventions to improve outcomes for YLHIV in the context of adult care.
The results of this review show that in most cases , the introduction of VG training in physical rehabilitation offered similar results as conventional therapy.
The results of this review suggest that a structured exercise program may be physically beneficial for middle-aged to older cancer survivors.
The results of this study are consistent with , but do not prove the hypothesis that high tHcy causes cognitive impairment in later life.
The results of this study call attention to a field of lacking evidence in alcohol-related problems of older persons.
The results of this study demonstrated that LV GLS , GRS , GCS , and GAT decrease with age.
The results of this study have implications for the detection and prevention of depression in LTC.
The results of this study indicate that the majority of elderly women were not meeting their calcium requirements from diet alone.
The results of this study indicate that the participants perceived improvements in some aspects of their quality of life.
The results of this study map the variation in expression of proteins and pathways often implicated in disease , and so have significant clinical implication.
The results of this study may serve as a basis for community nurses to manage care for older adults in deprived neighbourhoods.
The results of this study project a continuous increase in mesothelioma incidence in South Korea over the next @number@ years.
The results of this study provide cross-cultural evidence for the potential application of this scale in Chinese older people.
The results of this study provide information for future longitudinal studies with multi-factorial interventional design in order to determine the effects of the causal relationships.
The results of this study replicate and extend previous findings in separate participant samples above and below @number@ years of age.
The results of this study reported that the sensitivity of the Mini-Cog was @number@ and the specificity was @number@
The results of this study revealed that older adults require significantly higher activation of several areas to perform the same motor task as younger adults.
The results of this study show that significant inter-scanner differences in QCT-based measurements of BMD and bone strength can remain even when using an ASP.
The results of this study show the human DNA and face get more complex by aging.
The results of this study support research demonstrating a difference between the caregiving experiences of women and men.
The results of t-test showed good discriminant validity of the WHOQOL-OLD between the healthy group and the unhealthy group ( P < @number@ ) .
The results of western blot and immunohistochemical analysis confirmed the expression of LDHC downregulation in the aged testis.
The results on BDI were not related to either MoCA or MMSE.
The results on the ( cost- ) effectiveness of this strategy based on a large , randomized , controlled trial are expected in @number@
The results over a mean follow-up period of @number@ months were good , with high patient satisfaction.
The results pertaining to patella lead were similar to those observed for tibia lead.
The results point to an increasingly female and aging membership , which continues to be employed primarily in private practices and universities.
The results point to an unexpected function of SPRTN and bring insight to the mechanisms that link premature aging and cancer.
The results presented here indicate that dedicated oxaloacetate decarboxylases exist in eukaryotes.
The results presented here may be relevant for understanding the association between exposure to traffic-generated particulate pollution and enhanced skin aging reported in epidemiology studies.
The results presented here should be useful for researchers who want to use accelerometry to evaluate steady postural balance.
The results presented provide important insights into hepatic physiology and function , especially drug metabolism , with respect to sex and age.
The results provide a foundation for investigating the role of training in improving the interplay between anticipatory and compensatory postural control in older adults.
The results provide an insight into issues of growing age from the patient's perspective.
The results provide a rationale for the use of diclofenac + heparin also in algogenic conditions without evident signs of injury / edema / hematoma.
The results provide a strong argument for further development of intranasal oxytocin for migraine prophylaxis.
The results provide evidence for a limited role of attention modification of the 40-Hz ASSRs in children around the age of @number@ years old.
The results provide evidence that connectional topology of brain areas quantified at rest relates to the functional activity of those areas during task.
The results provide evidence that working memory does not support the processes that revise the structure and interpretation of sentences and discourse.
The results provide further evidence for the role of emotion perception in a range of important social deficits.
The results provide further evidence that APOE ε4 has a significant impact on the trajectory of age-related cognitive functioning in older adults.
The results provide further evidence that disruption of DNA methylation is involved in the pathological process of AD.
The results provide insight into some of the mechanisms underlying age-related changes in the respiratory system.
The results provide insight into the genetics of excitement-seeking and risk-taking , and are relevant to hyperactivity , substance use , antisocial and bipolar disorders.
The results provide support for the feasibility of a LWAH risk management process that links community-residing older persons with community-based long-term care options.
The results reflected that HV-related muscle injection of BTX-A resulted in a marked reduction in pain for up to @number@ months.
The results remained after adjusting for lifestyle and vascular factors but not after adjusting for depressive symptoms.
The results remained robust after accounting for multiple confounders and for cognitive status , slow gait , previous falls , and frailty.
The results remained significant after adjusting for multiple risk factors including age , sex , race , education , and presence of an APOEɛ4 allele.
The results remained significant even after controlling for the co-morbidities , as well as after adding in the model anxiety and depression as covariates.
The results remained unchanged when the model was further adjusted for ethnicity.
The results remain robust to several alternative specifications.
The results remain significant when we control for QoL and personality.
The results replicated past reports of increased errors with reduced target prevalence in adults.
The results replicate the CI effect in sequence learning in both young and older adults.
The results reported here can be seen as the first step toward mechanical mapping of the arterial tree.
The results reveal an enormous growth of urban medical service demand in the future.
The results reveal a very high prevalence of mental disorders among older prisoners , notably depression and anxiety.
The results revealed alterations in the amplitude of N170 and the localization of areas with maximum neural activation.
The results revealed a parallel increase in CP I and the @number@ kDa CN-Aα ( ΔCN-Aα48 ) proteolytic fragment in cytosolic fractions during MCI.
The results revealed a significant relationship between PTA ( low ) and MMSE only in the younger age group.
The results revealed a steady decline in response rate and amplitude with advancing age beyond 5th decade ( 50-60 years ) .
The results revealed a steady increase in vaccination coverage in every subgroup during four consecutive seasons.
The results revealed different accuracy rates across three different kernel methods adopted in the classifier , with the linear kernel performing the best.
The results revealed longer latencies of both mismatch negativity and P300 and slower and far less accurate responses as neurodegeneration progressed.
The results revealed no significant differences in the distributions of genotype or allele between LOAD and control groups in the total sample.
The results revealed satisfactory test-retest reliability ( @number@ ) of odor recognition memory.
The results revealed significantly lower local connectivity in the default network and higher local connectivity in the somatomotor network in aMCI patients.
The results revealed that arousal improved younger adults ' within-item memory binding but not that of older adults.
The results revealed that each characteristic phenomenon of AF influenced hemodynamics.
The results revealed that grandmothers with fewer children and those who enjoyed the grandparenting tasks more were more sensitive in their interactions with their grandchildren.
The results revealed that individuals with less emotional stability were more likely to take over the responsibility to provide care.
The results revealed that , in fair lineups , aging was associated with a genuine decline in recognition not an increased willingness to choose.
The results revealed that none of the enteric pathogens were detected in any of the samples tested.
The results revealed that osteons , on average , are not circular in cross-section and that 3D orientation cannot account for deviation from circular shape.
The results revealed that @percent@ of the sample presented well-preserved chemosensory abilities , whereas @percent@ of the participants presented a moderate impairment.
The results revealed that relicensing policies instituted by states yield inconsistent results in terms of reducing traffic crashes , traffic violations , and traffic-related fatalities.
The results revealed that the relationship between age and Step Test performance was attenuated when we controlled for potential confounding variables.
The results reveal that daughters experience the highest burden but also the highest self-esteem , suggesting the role is less salient for their self-identities.
The results reveal that the system can give a viable indoor air quality appraisal in order to anticipate technical interventions for improving indoor air quality.
The results reveal the complexity of how one handles the material room.
The results satisfied our null hypothesis and were statistically significant.
The results should motivate researchers to consider non-linearity in this field more frequently.
The results should sensitise healthcare managers to improve nursing training and education , according to clinical risk management perspectives.
The results show an automatic bone detection rate of @number@ and an average segmentation accuracy of @number@ using the Dice similarity index.
The results show an increase of amyloid accumulation and allele frequency of APOE4 in the mTBI patients with cognitive impairment.
The results show an inequitable distribution ( p < 0.01 ) of birth dates by quarter for almost all age groups and both genders.
The results show dependence on age ( P = @number@ ) and ethnicity ( P = @number@ ) .
The results showed a capacity analysis which was used to convey strategic measures for staff recruitment and retention.
The results showed a change in both performance and behaviour at the age of @number@ years old.
The results showed an age difference in strategy selection in relation to concreteness level.
The results showed a positive and significant association between education , occupation , and leisure activities and the cognitive performances on Isaac's set test.
The results showed better performance compared with those results published previously using force platforms to evaluate postural sway.
The results showed differences between younger and older adults in the modulation of response- and feedback-related negativities by feedback validity.
The results showed dissociations in the performances of older versus younger adults.
The results showed equivalent performance on the Simon task across groups but different underlying neural substrates in the two groups.
The results showed no floor and ceiling effects.
The results showed no statistically significant differences among the groups.
The results showed significant atrophy across much of the cerebral cortex with bilateral transverse temporal regions shrinking the fastest.
The results showed significant relationships between television viewing time and individual , social , and physical environmental factors.
The results showed that aging decreased the failure properties of all three ligaments ( failure load , failure elongation ) .
The results showed that agonist activation increased in both age groups with increasing intensity.
The results showed that although the frailty perspective dominated , vulnerability also had positive meanings for the older persons.
The results showed that AMDTs were significantly correlated with FMDTs , but not with FMDTs measured with interfering AM.
The results showed that anti-CMV IgG titers did not change over twelve years.
The results showed that BAX , a proapoptotic protein , was induced by DRAM1 in a transcription-independent manner.
The results showed that both CGRP and klotho mRNA expression were reduced in Ang II-induced senescent EPCs.
The results showed that both hormones caused clear improvements in both tasks.
The results showed that both NADPH and apocynin markedly attenuated ischemia / reperfusion-induced increases in the levels of NOX2 , NOX4 and ROS.
The results showed that chronic illnesses influenced out-of-pocket health care costs.
The results showed that depending on the period of the disease , the process of inflammation is deregulated in different ways.
The results showed that exercise frequency and well-being were positively correlated , but a negative correlation was found between exercise intensity and well-being.
The results showed that facial displays influenced perception such that the same voice was heard differently depending on the age of the accompanying face.
The results showed that IFNα therapy could upregulate the expression of hTERT mRNA in PBMCs.
The results showed that intra-peritoneal injections of silica nanoparticles could increase bone mineral density , with little observed toxic side effects.
The results showed that kaempferol decreased cell viability as concentration- and time-dependently.
The results showed that large individual differences exist in the number of HSPCs , as well as in the surviving fraction of cells.
The results showed that modified SE is able to quantify the degree of regularity of the signals regardless of sampling rate.
The results showed that more than @percent@ of the respondents agreed with earlier onset aging characteristics of people with ID.
The results showed that most ( @number@ % ) of the participants used supplements.
The results showed that most selected xyloketals could protect Caenorhabditis elegans against heat stress and extend the lifespan of worms.
The results showed that NMES significantly enhanced the MEP in all @number@ groups.
The results showed that @percent@ formula @number@ was the most effective formula for promotion of fibroblast and keratinocyte proliferation.
The results showed that performance ( time of platform search and distance traveled ) was negatively related to age.
The results showed that phenolic compounds presented four evolution patterns along with wine aging in bottle , mainly depending on their chemical nature.
The results showed that PLL strongly inhibited PrP ( Sc ) propagation in the cell-free , cell culture , and mouse models of prion disease.
The results showed that recognition of happy expressions , irrespective of eye-gaze direction , engaged the critical nodes of the default mode network.
The results showed that response interference effects differ across sensory modalities , but not across age groups.
The results showed that serum antibody responses to P. jirovecii MsgC fragments were significantly and independently decreased in current smokers.
The results showed that siblings and controls did not differ significantly on grey matter volume or concentration.
The results showed that the cells of the treated groups grew better than the untreated groups.
The results showed that the evolution of these functions was similar in humans and mice , with a decrease in old subjects.
The results showed that the experiments had feasibility , reproducibility and universality.
The results showed that the expression of CFTR on the equatorial segment and neck region of sperm was significantly decreased in an age-dependent manner.
The results showed that the factor structure of the Dutch version of the MCQ corresponded well with that of the English version of the MCQ.
The results showed that the forward selection algorithm outperformed the other techniques for this particular problem.
The results showed that the FRI captures the risk of falls with accuracy that is similar to that of conventional performance-based tests of fall risk.
The results showed that the length-breadth ratio of MSC increased and nucleocytoplasmic ratio decreased along with the increasing of passages.
The results showed that the model adequately predicted the empirical pattern of results.
The results showed that the odds of reporting poor health was @number@ times higher among the old-old compared to the young old.
The results showed that the older adults had similar patterns of joint movement and COM excursion as the young adults during the balance reactive-recovery.
The results showed that the onset of predictive sensory information for synchrony judgments was not different between groups.
The results showed that there is substantial total volume loss and cortical thinning in cognitively healthy older persons.
The results showed that the relative risk for hospital admission for hypertension has high-value clusters in the south and southeastern Shenzhen.
The results showed that the telomere length , the hTERT gene expression , and the telomerase activity had significantly increased.
The results showed that the tensile properties and thermal stability of the scaffolds were significantly enhanced.
The results showed that the timing of terminating gaze anchoring relative to pointing completion oscillated considerably during the HS1 practice until it was stabilized.
The results showed that the vertebra-to-front skin distance increased with age.
The results showed that YA had increased learning under the more challenging response selection conditions ( experiments @number@ and @number@ ) while OA did not.
The results showed that young adults outperformed older adults in all recall tasks.
The results showed the commitment of elder patients and the contribution of Mobilicare to the maintenance of a patient's health stability.
The results showed the negatively associated between CRP level and physical performance when adjusted for the confounding factors.
The results show evidence that physical activity and cognitive exercise may improve memory and executive functions in older people with MCI.
The results show no significant correlation between TL , mitochondrial DNA hgs and longevity.
The results show significant changes in the test group , demonstrating improved cognitive performance and quality of life perception.
The results show structural perturbations in MG-Lys-Cu ( 2 + ) -DNA generating new epitopes that render the molecule immunogenic.
The results show that aging has a heterogenous effects across regions.
The results show that agriculturalists have the lowest scores for entheseal changes , with hunte-gatherers next highest and those working in industry the highest.
The results show that a large proportion of the Israeli population feel underprepared for retirement.
The results show that angular second moment increases as age increases , and entropy decreases as age increases.
The results show that ApoE e4 was a significant effect modifier.
The results show that fungi were more frequently isolated from the aging stage and that the predominant filamentous fungal genus isolated was Penicillium.
The results show that health expenditure in Italy reacts more to the ageing population compared with life expectancy and per capita GDP.
The results show that HFE p.H63D polymorphism is not associated with WML severity in the whole cohort.
The results show that higher order aberrations of the whole cornea are influenced mainly by the anterior surface aberrations.
The results show that increasing feature overlap leads to greater interference from the unattended visual field.
The results show that latent T. gondii infection is neglected but an important neurobiological modulator of cognitive functions in elderly individuals.
The results show that men with strong masculinity beliefs are half as likely as men with more moderate masculinity beliefs to receive preventive care.
The results show that music not only effectively evokes autobiographical memories , but that these memories are more vivid than those evoked by famous faces.
The results show that NEG caused a @percent@ reduction in propagation fracture toughness ( R-curve slope ) .
The results show that not only health aspects varied along the ageing process , objective and perceived aspects of home also changed.
The results show that @number@ presented a marked enhancement of both nuclear protein levels and activity of PPARβ / δ in fibroblasts.
The results show that older participants required a longer time and made more frequent errors in rejecting metaphors versus literally false statements.
The results show that one third of the predicted reversible disulfide containing proteins are well-known redox enzymes , while the remaining are non-enzyme proteins.
The results show that past studies of voluntary orienting in older adults confound involuntary and voluntary orienting.
The results show that patients with the p.Ala53Glu mutation share a haplotype spanning a minimum of @number@ Mb suggesting a common founder.
The results show that some medical criteria are highly accepted for prioritizing patients whereas socio-economic criteria are rejected.
The results show that spousal labor market participation plays a large role in work-exit transitions , even when retirement is involuntary.
The results show that the N71D mutant resembles , structurally and functionally , the wild type enzyme.
The results show that the physiology of male skin partly changes with aging.
The results show that the prevalence of slightly undermet needs decreased in urban China from @number@ to @number@
The results show that there are @number@ specific lysine-arginine pairs that , due to their relative position and configuration , are likely to form glucosepane.
The results show that the strength of the rightward perceptual bias in linguistic bilateral ( dichotic ) stimulus condition changes as a function of age.
The results show that two self-enhancement values , achievement and hedonism , discourage disability retirement but do not affect nondisability retirement.
The results show that waist circumference was the only measure of body fat distribution independently associated with mobility ( p ≤ @number@ ) .
The results show the influence of temperature in %PPP and how this molecule could serve as a better monitor of the storage period of VOOs.
The results show us that , @percent@ of the subjects reported a score below @percent@ on average reported a QoL of @number@ ± @percent@.
The results substantiate need for correction of hemostasis by reducing the IR.
The results suggest age-related compensatory increases in RSFC which might help to maintain cognitive performance.
The results suggest a mechanism for the involvement of small molecules in disease development.
The results suggest a modest expansion of morbidity over the life course , most of which is accounted for by only three causes.
The results suggest an increase in noise within the visuomotor control system may contribute to the decline in motor performance during early aging.
The results suggest a possible causal link between poor sleep and cognitive decline.
The results suggest distinction between overhead and first-person view perspective taking in the impairment of aMCI patients and the sex differences.
The results suggested IIV increased over time , particularly in participants aged over @number@ years.
The results suggested that there is inconclusive evident to support the use of non-slip socks to prevent falls among hospitalized older adults.
The results suggest further that the elderly can adjust their reduced neuromuscular capacity to match the demands set by different exercise intensities.
The results suggest that 3-year-olds exhibit a yes bias automatically , but 5- and 6-year-olds are sensitive to question context.
The results suggest that , across all conditions , younger adults generated more internal details than older adults.
The results suggest that a DRVS extract may be effective in slowing skin aging through its antioxidative properties and by down-regulating MMP-1 expression.
The results suggest that a few measurements can be used as parameters of vertebral maturation both for males and females.
The results suggest that age affects TGF-β signalling in leukocytes by altering the expression levels of its receptors.
The results suggest that age influences community-dwelling older adults ' well-being to a greater extent than it does to institutionalized older people.
The results suggest that ageing is not primarily associated with loss of ability to synthesise matrix proteins and matrix-degrading enzymes.
The results suggest that age plays an important role in the relationship between sleep duration and mortality.
The results suggest that an Aβ ( @number@ ) -dependent impairment in brain anandamide mobilization contributes to cognitive dysfunction in AD.
The results suggest that better verbal fluency precedes intellectual investment in old age rather than the other way around.
The results suggest that brain structural atrophy may disrupt brain response in aging brains , which then show less brain engagement in semantic integration.
The results suggest that CAE can prevent photo-damage in skin through inhibiting MMP expression and MAP kinase pathway.
The results suggest that cognitive impairment is an important feature of NF1 across lifespan , including elderly individuals.
The results suggest that compromising the function of TDP-43 in regulating protein homeostasis may contribute to the pathogenesis of related neurodegenerative diseases.
The results suggest that continued hands-on experience in spatial domains is a predictor of maintenance of spatial ability across the life span.
The results suggest that ethnic minorities may not have benefited from newer treatments to the same extent as nHw patients have.
The results suggest that , even at a mild stage of the pathology , people exhibit difficulties in selecting relevant objects.
The results suggest that filling this home care gap would significantly raise quality of life by increasing social and environmental resilience to age in place.
The results suggest that FOK accuracy may be partially determined by search processes triggered when participants are queried for contextual information.
The results suggest that general attitudes need to be changed by the inclusion of geriatric dentistry in the dental curriculum.
The results suggest that GH is more important in strengthening the matrix tissue than for muscle cell hypertrophy in adult human musculotendinous tissue.
The results suggest that higher conscientiousness is protective of late-life cognitive health.
The results suggest that higher rates of regional microstructural degeneration are potential markers of PD progression.
The results suggest that homocysteine metabolism is not likely to predict familial longevity.
The results suggest that idiopathic gait disturbance is the final stage of the aging process of postural system.
The results suggest that image recognition was effective in localizing a human body part.
The results suggest that older and young adults are achieving control of their expressions through different mechanisms or strategies.
The results suggest that older individuals have better satisfaction with life even though they have greater functional impairment.
The results suggest that overexpression of p190 mRNA may be involved in the carcinogenesis of lung adenocarcinoma.
The results suggest that patients with EOS have a deficiency of the expected cortical thinning to occur during adolescence development.
The results suggest that patterns of whole-brain functional connection may be a useful risk marker for conversion to AD in aMCI patients.
The results suggest that PCOS pathophysiology may be related to alterations of a cross stalk between glucocorticoid signaling , age , and metabolic parameters.
The results suggest that population aging is a major driver behind the rapid rise in IHD mortality.
The results suggest that postural sway characteristics and the cortical and proprioceptive feedback were not limited when using the apparatus.
The results suggest that program components that target self-efficacy should be incorporated in future hip fracture rehabilitation interventions.
The results suggest that sensitivity to the two kinds of stimuli is affected differently by aging.
The results suggest that short-term changes in air pollution were associated with augmentation index and augmentation pressure at several moving averages.
The results suggest that the cellular-level sequelae of nonsupportive parenting and stress are not immutable.
The results suggest that the custom designed IR thermal image system may be used as an effective tool for noncontact detection of dry eye.
The results suggest that the endogenous estrogens may be associated with deceleration of cellular aging.
The results suggest that the indirect tensile test may only be recommended as a screening test especially for low or medium strength resin composite cements.
The results suggest that the NIS has the potential to promote the health and well-being of community-living seniors.
The results suggest that there is a positive association between SSPA and PA levels in older adults , especially when it comes from family members.
The results suggest that there is greater AT use in this sample than in same-aged adults in national samples.
The results suggest that these major components of bipolar disorder may represent distinct underlying pathways rather than increasingly severe manifestations of a common underlying diathesis.
The results suggest that this nanoprobe represents a promising approach for detection of hydroxyl radicals in biological systems.
The results suggest that with age , there is a decline in semantic processing during sentence comprehension.
The results suggest that WSC priming is age-invariant up to very old age.
The results suggest that younger and older individuals perform the task similarly by rehearsing or reformulating the intention.
The results suggest the higher mtDNA content may convey a beneficial effect to the longevity of people through assuring sufficient energy supply.
The results suggest the importance of knee extension strength to maintain the bone health of the proximal femur and spine in aging particularly in men.
The results suggest the locomotor system is adaptive enough to complete a working memory task without compromising gait performance when walking at a self-selected pace.
The results support a possible association , but more epidemiological studies with better viral identification and localization methods are needed to verify these findings.
The results support a potential role of VSEP for the detection of very early neurodegenerative processes which may precede Alzheimer's disease.
The results support a user-specific design for small technical devices with touch interfaces.
The results support claims of decompositional analysis of idioms during later processing stages and of obligatory activation of figurative meanings.
The results supported the differentiation of Rowe and Kahn's engagement with life component into caring and productive engagements.
The results supported the former rather than the latter alternative.
The results support that changes in access to structural social capital over time impact on SRH.
The results support that the scale is a valid and reliable measure for determing gender satisfaction.
The results support the assumption that EOAD takes a more malignant course than LOAD.
The results support the existing findings that PD is related to verbal fluency.
The results support the hypothesis that abnormal eye movements are more likely to be an effect and not the cause of reading difficulties.
The results support the view that motor control in aging is influenced by executive control and have implications for theories of cognitive training and transfer.
The results therefore suggest that weight loss improved SNS / PNS balance especially when CR is combined with exercise.
The result suggests that children exposed to GDM have higher adiposity ; prevention of childhood obesity needs to begin early in life for these children.
The results underscore the importance of time and emotional resources as predictors of sensitive parenting among grandmothers.
The results were adjusted for age and education.
The results were analyzed by correlating the study factors and the prevalence of TMD.
The results were attenuated by correction for BMI , but remained significant.
The results were broadly consistent with Burke's system theory of organizational change.
The results were compared to overall liver volume and injury scales.
The results were compared to those of small bowel mucosa from CD patients without carcinoma and @number@ small bowel carcinomas from a non-CD origin.
The results were compared to two other major acute geriatric issues : infectious diseases and hip fracture.
The results were compared using two-way analysis of variance.
The results were compared with a non-parametric statistical test , the Wilcoxon's exact test.
The results were compared with distributions of these lipids and proteins in human donor eyes with AMD.
The results were compared with previous data for adult masseter and biceps muscles.
The results were compared with previously published standard values.
The results were compared with the same measurements that had been obtained prior to transplantation in the recipients ' pre-implantation donor livers.
The results were confirmed by genetic analysis.
The results were consistent in subgroup analyses stratified by age , sex , race , and baseline cardiovascular disease.
The results were contrasted with a published perspective taking test ( Standardized Road-Map Test of Direction Sense , RMTDS ) .
The results were evaluated using SPSS @number@
The results were further confirmed by qRT-PCR.
The results were further confirmed by Quantitative Real-Time PCR ( qRT-PCR ) .
The results were inconclusive regarding food diversity for complementary feeding.
The results were judged by three dermatologists who had not taken part in the treatments.
The results were not statistically significant.
The results were opposite for the FCF group.
The results were pooled using a random-effects model.
The results were presented to Congress which , in turn , authorized for-profit PACE providers.
The results were replicated in @number@ participants from NHANES 2003-2004.
The results were robust to several sensitivity analyses that limit both known and unknown forms of genetic pleiotropy.
The results were similar in men and women and were not dependent on the presence of CKD.
The results were statistically analyzed to evaluate the associations between levels of GDF-11 and β2-MG , and ageing and cognitive impairments.
The results were subjected to correlation analysis versus standard hemostatic parameters.
The results were submitted to ANOVA and Tukey's test at @percent@ level of significance.
The results were tabulated to assess the safety and efficacy of the Endotine device.
The results were then compared between the two groups.
The results were then compared with the findings of the IE.
The results were then set into relation to today's lip rejuvenation procedures.
The results were validated in @number@ unrelated postmenopausal Japanese women with osteoporosis and @number@ non-institutionalized , community-dwelling Japanese adults.
The results were valuable for determining the degree of frailty of a specific patient in relation to other patients in an elderly population.
The results were verified in a second retrospective study including @number@ routine samples.
The results will be of interest to professionals and researchers focused on career development , older workers , and retirement.
The results will be used to inform future dementia prevention trials that focus on delirium intervention.
The results will inform policymakers on strategies to implement in the near future.
The results will provide insight into the detrimental changes associated with the human aging process and how CR mitigates these effects.
The results will support commissioners and providers with decisions about implementation.
The results would be relevant to many rapidly ageing societies in this region.
The result was a single factor score reflecting arterial stiffness and reduced elasticity.
The result was statistically analyzed.
The retention paradigm mirrored the recruitment plan but was based on specifically developed approaches.
The retina appeared fully attached and a macular hole with flattened edges was still detectable.
The retina is considered an immune-privileged tissue as a result of its unique anatomic and physiologic properties.
The retina is highly susceptible to photochemical damage from continuous exposure of light and oxygen.
The retinal blood flow velocity ( BFV ) was measured using a Retinal Function Imager ( RFI ) .
The retinal break was located along the superotemporal arcade and over an area of the patchy chorioretinal atrophy in both eyes.
The retinal cell suspension is homogenized , filtered and loaded onto a continuous sucrose gradient.
The retinal effect of the laser was determined in human and mouse eyes using immunohistochemistry and compared with untreated eyes.
The retinal homeostasis of zinc is dysregulated in systemic zinc depletion , aging and diseases such as age-related macular degeneration.
The retinal pigment epithelium ( RPE ) is a highly specialized CNS tissue that plays crucial roles in retinal homeostasis.
The retinal vascular DF was analyzed to determine changes with increasing age.
The retinal vasculature and NV were evaluated on P21.
The retinal vasculature supplies cells of the inner and middle layers of the retina with oxygen and nutrients.
The retinal vessels were segmented using computer-assisted software , and non-vessel fragments were deleted.
The retina originates in the central nervous system.
The retinoblastoma @number@ ( RB1 ) tumor suppressor is a critical regulator of cell cycle progression and development.
The retirement experience varies , depending on people's circumstances.
The retrotransposition process is dependent upon the ORF2 protein ( ORF2p ) .
The return rate was @percent@ with the majority of respondents having @number@ years or more working experience in general practice.
Thereupon , this study was conducted to evaluate the age-related recurrence patterns after conservative surgery for endometrioma.
The revelation that mast cells can influence organs , tissues , and cells has increased interest in mast cell research during liver disease.
The reversal of T cell abnormalities of immunosenescence by low concentrations of lenalidomide suggest a potential for improvement of immunity in the elderly.
The reversal of these perturbations by such natural metabolites as pyruvate , α-ketoglutarate , acetoacetate and L-carnitine provides valuable therapeutic cues against AD.
The reverse causality is also conceivable but has not been sufficiently considered.
The review also describes the molecular basis of memory in hippocampus called as ' long-term potentiation'.
The review also discusses the significance of verbalization in a dual-task setting for increasing cognitive-motor interference.
The review also sought to identify and explore the perceptions and experiences of older adult patients and those involved with their care.
The review attends to the limited body of qualitative research in the field , some of which claims a politicized empiricism of ' voice'.
The review concludes with a discussion of management strategies.
The review contains different aspects indicating the participation of cytokines in aging-associated diseases.
The review contains literature data about calcium metabolism regulation in different periods of growth and development.
The review describes neuro-immuno-endocrine signal molecules expression in human endometrial cells in the normal conditions , in the pathology and during aging.
The review discusses current findings and their implication in the aging process.
The reviewed post-operative photographs were taken at @number@ weeks and @number@ months.
The review ends with two examples of multifaceted evaluations attempting to get at these deeper issues.
The reviewers conducted quality ratings based on the Cochrane risk-of-bias criteria for each study.
The review findings will help inform the design of future theory-based adherence interventions.
The review found that numerous physiological and pathological changes may occur with age and alter vital signs.
The review found two randomized control trials and two prospective cohort studies that met the inclusion criteria.
The review highlights the common issues which both U.S. and European researchers have identified and attempted to tackle.
The review included @number@ English-language studies with HRQOL as a primary outcome and that assessed personality from the psychological perspective.
The review included only population and epidemiological studies in English since @number@ with samples in European countries with subjects aged @number@ years and above.
The review of the peptides used in dermatocosmetology is represented.
The review on associative communications of periodontal diseases , aging and age associated pathology is submitted.
The review protocol was registered with the International Prospective Register of Systematic Reviews ( @url@
The review raises important theoretical and methodological issues , and areas for future research.
The review shows that variations in gross placental morphology at birth predict a wide range of disorders in later life.
The review summaries the current research on CoQ10 bioavailability and highlights the headways to obtain a satisfactory intracellular and targeted mitochondrial delivery.
The review then will discuss the specific nuclear medicine studies that typically are obtained in patients in this age group.
The review told that decrease of expression of heat shock proteins can be one of the main causes of aging.
The review used submissions as well as recent publications and results from external and EMA databases.
The review was conducted and reported in accordance with the PRISMA statement.
The review will also be expanded to related molecules which are agonists to the nuclear receptors.
The review will specifically focus on emerging research identifying neural , cognitive , and social markers of declining financial decision-making capacity in older adults.
The Reviscometer ( ® ) RVM600 device is capable of measuring directionality of forces on the skin.
The Reviscometer ( ® ) RVM600 was used to measure resonance-running time ( RRT ) every 10° from 0° to 350°.
The revised Dietary Guideline Index ( DGI-2013 ) scores individuals ' diets according to their compliance with the Australian Dietary Guideline ( ADG ) .
The revised MAT was reliable with an ICC of @number@ ( 95%CI : @number@.52-0.79 ) .
The revised scale was validated by examining the scale's distribution with a self-reported dementia diagnosis , functional problems , living status , and distress measures.
The revised tool triggered a speech-language consult for positive screens and demonstrated higher scores in user satisfaction and task efficiency.
The revision rate was @number@ percent.
There was 3- to 5-fold variation in BUB1 , BUB1B , and CDK1 transcript abundance among individual oocytes from a single patient.
There was a 3-fold increase in cell proliferation when HCE cells were incubated with @number@ nM 15-epi-LXA4 for @number@ h.
There was a bidirectional relationship between walking speed and fluid cognition.
There was a broad consensus within all three workgroups that much additional work is needed to validate the application of biomarkers for diagnostic purposes.
There was acceptable internal consistency of the PDQ-8 ( Cronbach's α : @number@ Item-scale correlation efficient : @number@.56-0.72 ) .
There was a clear trend for increasing magnitudes of association with lowering childhood SEP.
There was a close correlation between grade and MMP-9.
There was a consistent positive association between OABSS severity , including urgency incontinence , and CDR scores.
There was a correlation between BP values , age , and percent body fat.
There was a correlation of normalized RV IVAc with normalized TAPSE and RV S'.
There was a corresponding increase in component BASMI scores , which was more pronounced for some components than others.
There was a corresponding increase in the prevalence of laxative use from @percent@ to @percent@ over the same period.
There was a decline with ToM as well as non-mental task abilities with age.
There was a decrease in LV dimensions with advancing age ( p < 0.001 ) .
There was a deficiency of collagen and its impaired maturation in all the study cases of vascular aging in the presence of aortic dissection.
There was a diffuse dose-dependent negative association between smoking and cortical thickness.
There was a direct correlation between the diameter of the vessels and the number of associated CAs.
There was a direct relationship between epithelial height and RBM thickness ( r = 0.6 , p < 0.001 ) .
There was a dose-dependent increase in lens transmission with increasing laser irradiation.
There was a dose-response relationship with the duration of COPD after controlling for the potential covariates.
There was a good correlation between complete and reduced scales ( coefficient of correlation @number@ ) .
There was a good correlation between OST and MST in each of the three age groups of both sexes.
There was a good targeting for the SGRQ domains , except the Impact domain ( @number@ ) .
There was a graded relationship between BP and total mortality ( P < @number@ ) .
There was a gradual increase in RLS prevalence by advancing age , however , sex difference disappeared after adjustment.
There was a gradual increase in the wear rate below an oxidation index of @number@ and a drastic increase thereafter.
There was a greater association of revascularization events by increasing score group.
There was a high correlation between the eyes of the same subject.
There was a higher predicted gestational age for placentas from early onset preeclampsia cases , but not term preeclampsia , compared with their chronological age.
There was a high level of interest for long-term care services among consumers and tribal leaders.
There was a lack of associations between weight and cognition in women who remained stable or gained weight.
There was a lack of inversion effect during the recognition of original faces by older adults.
There was a lack of knowledge and understanding about the patient's lifeworld.
There was a lack of renal , muscle or bone biomarkers.
There was a large multistate outbreak of WNV in @number@ with more human disease cases reported nationally than any year since @number@
There was a larger reduction in process length and arborized area in AD compared to aged-matched control microglia.
There was a large variation in the measure of prevalence used by individual studies and in their definition of chronic pain.
There was a linear correlation between the values of AUC ( ∞ ) of paracetamol , its glucuronide and sulphate metabolites and GFR.
There was a linear relation between twist and displacement during systole , and the slope increased gradually with the increase in age.
There was a link between certain microorganisms with specific OAI and age of patients.
There was also a correlation between TRF length and glomerular filtration rate ( r = -0.184 , P < 0.05 ) .
There was also a general trend for T2 to decrease in inferior temporal lobe grey matter in the voxel-based regression.
There was also an association between vegetable intake and prevalence of depressive symptoms at higher levels of intake.
There was also an indication toward lower cognition in all nonsignificant analyses.
There was also a reversal of connectivity in the right hippocampus.
There was also a shift to larger mesangial area and increased macrophage staining in diabetic WT mice compared with Papp-A KO mice.
There was also a significant correlation between MG expression grade and CD45 cell infiltration ( r = @number@ P = @number@ ) .
There was also a significant decrease in loneliness after exergaming , but little differences were found across different play types or age groups.
There was also a significant difference in attitudes concerning the role of the physician as the leader of the interprofessional team.
There was also a significant improvement in clinical symptoms in patients of the electromagnetic group.
There was also a slower return of bowel function with epidural analgesia than with spinal analgesia and PCA.
There was also associated band-like decreased T1 and T2 signal of the endplates.
There was also a trend towards increased risk among the heaviest consumers using the MSM ( RR = @number@ @percent@ CI = @number@.93-2.72 ) .
There was also a very high incidence of spike discharges in participants whose intellectual quotient was very low or low.
There was also a weaker association between the A allele of rs4986938 and a decreased risk of decline in psychomotor speed.
There was also considerable variation in the perceived age data that was unaccounted for.
There was also evidence that greater total psychosocial adversity in childhood was associated with lower physical capability.
There was also evidence that the percentage of DLB cases with NSD showed wide variation across centers.
There was also no association between haplotypes and the increased arterial stiffness in this cohort.
There was also no association between PIM use and toxicity ( P = .93 ) or hospitalization ( P = .98 ) .
There was also no evidence of an interaction between PON1 and apolipoprotein E for any of these diseases.
There was also no reduction in the hybrid layer stiffness after @number@ and @number@ months aging as defined by the complex modulus and storage modulus.
There was also no significant association between benzodiazepine use at admission and history of falls in the previous @number@ days compared with non-users.
There was also no significant correlation between crowding and surround suppression.
There was also no significant myofiber atrophy or myofiber loss.
There was also no significant relationship between leukoaraiosis and other recognized cardiovascular risk factors.
There was also significant genetic covariance between SA and GCA , but not between 3DGI and GCA.
There was also suggestive evidence that penetrating brain injury may exacerbate the cognitive effects of normal aging.
There was a marginally significant positive correlation between the proportion of time spent in REM and immediate recall ability.
There was a marked shift in the employment settings and a decrease time worked as an APRN , despite an aging APRN workforce.
There was a mean loss of @number@ letters between examinations , with a 20-year loss of @number@ letters.
There was a moderately strong negative correlation between donor age and load ( P = @number@ ) .
There was a moderate significant correlation between VSM and HDS-R scores.
There was a modest and nonsignificant association of NEFA with diabetes ( P ( trend ) = @number@ ) .
There was a monotonically increasing risk of death with lower levels of educational attainment.
There was an age and gender variation in the percentile values.
There was an age-related decrease in SICI and an age-related decline in all dexterity measures.
There was an almost complete overlap between the assessments of individual items ranging from ( ρ ) @number@ and @number@
There was an association between 400-m walk time and minutes of MVPA ( ρ = -0.18 ; P < .001 ) .
There was an association between rs2070045-G allele and increased CSF-tau and more hippocampal atrophy.
There was an association between tau and causes of death ( p = @number@ ) .
There was an association between the number of medication drugs and risk of falling.
There was a negative relationship between age and adaptive behavior and the discrepancy between IQ and adaptive behavior increased with age.
There was an even stronger association between men presumed to be testosterone deficient and symptoms of anxiety ( p < 0.001 ) .
There was an increase both in the use of extensive neuropsychological assessments and in the use of cerebrospinal fluid diagnostics.
There was an increased presence of these abnormalities in patients who were classified as atherothrombotic stroke ( p = @number@ ) .
There was an increase in bacteria belonging to family Lachnospiraceae and Ruminococcaceae in GE-fed mice.
There was an increase in lean mass and a decrease in fat mass in the testosterone group but no differences in strength or physical performance.
There was an increase in muscle strength ( p < @number@ ) , regardless of obesity status.
There was an increase in the aggregate education level of APRNs ; however , the percentage educated at the doctoral level remained flat at @percent@.
There was an increase in % total LBM ( @number@.4±1.9% ) and decrease in % total body fat mass ( @number@.5±2.0% ) after ET.
There was an increase of @percent@ in deaths among the population in general , though @percent@ for the population over @number@ years of age.
There was an increasing trend of sarcopenia by age group and a decreasing trend with nutritional status.
There was an inverse association between adult height and CAC.
There was an inverse association between higher levels of socioeconomic factors and depressive symptoms in the study population.
There was an inverse statistically significant relationship between the total annual number of BP prescriptions and standardized HF incidence rates for the 10-year period 1999-2008.
There was a nonsignificant main effect ( p = @number@ ) for the between-subjects factor of age.
There was a non-significant trend for lower implantation rates in the younger donors.
There was a non-statistically significant age-related decline in MPOD in this particular population ( r = @number@ ) .
There was a notable scarcity of elastic fibers in the superficial layer of the LP.
There was an overall tendency towards decreasing modulatory effects of prior meal ingestion on food cue-evoked regional brain activity with increasing age.
There was an overall trend for increasing levels of inactivity and a reduction in vigorous activity.
There was an @percent@ pseudoarthrosis rate at levels treated with XLIF.
There was a @number@ increased odds ratio for HAND per @number@ log-value of HIV DNA ( 10-fold increase in copy number ) .
There was a @number@ µm RNFL thickness increase for every dioptre change in spherical power towards more hyperopia.
There was a pattern of increased risk of fatal stroke with higher TSH concentrations.
There was a @percent@ increase in annual incidence of unintentional therapeutic errors involving insulin , with a mean annual increase of @percent@.
There was a @percent@ increase in volumes and a @percent@ increase in surgical rates over time.
There was a @percent@ ( @number@ ) increase in deaths of those ≥85 years.
There was a persistent reduction in RA mortality , and on average , the ASMR declined by @percent@ per year.
There was a positive correlation between age and mean SUV of all aortic segments.
There was a positive correlation between DM duration and PSQI , GDS scores.
There was a positive correlation between increasing BMI and lung function at @number@ years of age.
There was a positive correlation between spiritual well-being and quality of life ( P = @number@ ) .
There was a positive correlation between the Cobb angle and the ScoliScore ( r = @number@ P < @number@ ) .
There was a positive correlation between the muscle thickness and electromyography results.
There was a positive correlation ( p = 0.039 ) between chronological age and the VR-QOL physical domain scores for the GP.
There was a positive correlation with aging , IPSS and prostate size.
There was a positive relation between MSNA and FVR ( P = @number@ ) in men but not women ( P = @number@ ) .
There was a positive relationship between spine BMD and moderate affection of renal function ( F = @number@ p = @number@ ) .
There was a predominance of dysfunctional variants in cases compared to controls.
There was a predominance of males ( 205 / 66 , @percent@ ) , mixed race , and low education levels.
There was a preferential stiffening of the thoracic aorta with age , which may be due to progressive fragmentation of elastin fibers in this region.
There was a previous history of hip fracture in @percent@ , and one or more vertebral fractures in @percent@.
There was a proportional relationship between the CMC and EF force and high-positive correlation between the CMC and EF strength in both groups.
There was a protein interaction between DRAM1 and BAX and this interaction prolonged the half-life of BAX.
There was a relative decline in the use of PD in the total dialysis population from @percent@ in @number@ to @percent@ in @number@
There was a significant age-related reduction in canceling contrast at @number@ Hz , but not at @number@ Hz.
There was a significant age-related reduction in perceived contrast of stimuli in the LVF versus UVF for both real and induced gratings.
There was a significant association between limitations in performing activities after the occurrence of falls and fractures.
There was a significant association between pure paraseptal emphysema and interstitial lung abnormalities ( P < 0.001 ) .
There was a significant association between shift type and sleep duration , showing that swing shift workers had longer sleep duration than day shift workers.
There was a significant correlation between age and stiffness of tendons assessed with strain indices.
There was a significant correlation between both factors when pooling all groups together but not when considering each group separately.
There was a significant correlation between levels of cadmium and creatinine in all children of both genders.
There was a significant correlation between myocardial telomere and aging.
There was a significant correlation between ovarian E2 and high-density lipoprotein cholesterol levels and the low-density lipoprotein ratio.
There was a significant correlation between the PPI deficit and a higher CGG repeat number.
There was a significant decline in social anxiousness and an increase in sociability for young-old participants playing with youths.
There was a significant decline in the number of Sertoli cells with age ; no such decline was found for Leydig cells.
There was a significant effect of age on FMD ( P = @number@ ) , with a reduction in FMD apparent postpuberty in males.
There was a significant effect of diet and generation on ex-vivo vasoconstriction in ageing females.
There was a significant first-order negative association between age and TL.
There was a significant gender effect , with females showing greater P300 amplitude than males.
There was a significant improvement in knee flexion and hip rotation ROM in the DIET group ( p < @number@ ) .
There was a significant increase in orbital aperture size ( increase in height of the superomedial and inferolateral orbital rim ) in both sexes.
There was a significant increase in plasma IL-1β levels in those homozygous for the disease-associated allele ( i.e. , IL-1β @number@ TT ) .
There was a significant increase in the strength and physical performance parameters in both men and women post-exercise ( all p < 0.05 ) .
There was a significant interaction between AI and hypertension ( P = 0.02 ) .
There was a significant interaction between sex and retinopathy for g.
There was a significant interaction of resilience and number of SLEs on depressive symptomatology ( p = @number@ ) .
There was a significant inverse association ( OBJECTIVES : Filipino Americans form the second-largest Asian American and Pacific Islanders subgroup.
There was a significant linear association between number of tasks provided and risk of burden in virtually all caregiver groups and domains of assistance.
There was a significant linear correlation between the brain activity metric and the glucose SUVR measurements.
There was a significantly lower proportion of the very elderly enrolled in the study ( P < @number@ ) .
There was a significantly promoted absorption of di / tripeptides in aged SHRs compared with young SHRs.
There was a significant negative correlation between age and choroidal thickness.
There was a significant negative correlation between age and relative improvement in performance ( δ = -.450 ; P = .009 ) .
There was a significant negative correlation between frailty and well-being ; the correlation coefficient between FI and CASP-19 scores was @number@
There was a significant negative correlation between informant reports of PM difficulties and nonfocal PM accuracy ( p < .01 ) .
There was a significant negative correlation between initial level of GCA and change ( r = @number@ ) .
There was a significant negative correlation between KD and TSSX.
There was a significant negative correlation between minimum f0 with breathiness ; jitter measures with tension ; and soft phonation index with roughness and instability.
There was a significant @percent@ decrease in plasmalogen choline , but no difference in other measured phospholipids.
There was a significant positive association between caregiver burden and incontinent patients , demonstrating that urinary incontinence in elderly patients produced greater caregiver burden.
There was a significant positive association between serum osteocalcin and high density lipoprotein ( HDL ) cholesterol ( p = @number@ ) .
There was a significant positive correlation between CFI and NLR ( r = @number@ p = @number@ ) .
There was a significant reduction in pigmentation , and the product almost completely protected against LC depletion.
There was a significant reduction of phonation tension and measure of F0 , jitter , and shimmer after the age of @number@ years.
There was a significant relationship between CD44s positivity and tumour diameter and lymph node involvement.
There was a significant reverse relationship between the frequency of return to donation and the time interval between donations.
There was a similar but non-significant pattern towards increased mortality in participants with moderate morale ( RR = @number@ P value = @number@ ) .
There was a similar increasing prevalence of abnormalities regardless of symptoms or shoulder dislocation.
There was a slight correlation between age and sex and age and height , but not between age and weight.
There was a small age-related statistically significant increase in G' , p = 0.003 , but not G " or |G |.
There was a small but insignificant increase in attractiveness scores in postprocedural photographs relative to preprocedural photographs ( P > @number@ ) .
There was a small difference between males and females that did not reach statistical significance ( r = @number@ ) .
There was a small mid-life peak for care-seeking and a slow general increase in reduced activities with increasing age.
There was association among this malocclusions , age and type of school , however there was not significant statistical association between malocclusion and gender.
There was a statistically significant decrease in arm circumference.
There was a statistically significant difference in the Klotho rs571118 SNP between chronological age groups , but not biological age groups.
There was a statistically significant improvement in all five aspects of the comprehensive grading scale.
There was a statistically significant improvement in wrinkle depth after treatment in all areas.
There was a statistically significant increase in sister chromatid exchange ( SCE ) test in the study group compared with the control group.
There was a statistically significant non-linear increase in RT with age.
There was a statistically significant positive correlation between the growth hormone peak and the cortisol peak.
There was a statistically significant trend for higher all-cause mortality with low serum testosterone levels in adjusted analyses ( P < @number@ ) .
There was a statistical tendency of decrease in the level of testosterone in gerontic aged women compared to middle aged.
There was a strong association between age and GST performance in the pitch and yaw planes ( r = @number@ p < @number@ ) .
There was a strong association between referral instrument scores and the corresponding single domain score of the questionnaire.
There was a strong correlation between the AMS score and depression.
There was a strong correlation between the most bothersome facial area and the area first planned for treatment.
There was a strong correlation between the summary indices of the PDQ-8 and the PDQ-39 ( r = 0.93 , P < 0.001 ) .
There was a strong correlation between YKL-40 and markers of neurodegeneration ( total tau and p-tau ) .
There was a strong direct relationship between FGF-23 and Klotho levels and a strong inverse relationship between sclerostin levels and pulse wave velocity.
There was a strong inverse dose-response association between wealth and depressive symptoms among all participants with disability.
There was a strong inverse relationship between number of ideal CVH metrics and prevalent CAC.
There was a strong linear relationship between tendon thickness and age.
There was a strong trend for Wellmune to decrease the number of symptom days ( P = @number@ ) .
There was a suggestion of effect modification by body mass index , whereby the association appeared strongest in participants with lower body mass indexes.
There was a suggestion that those with elevated total cholesterol may benefit.
There was a supplement effect in superoxide dismutase activity in younger adults only.
There was asymmetry of the caudate tail between the two sides in @number@ % of subjects.
There was a synergistic effect with liquid / creamy dietary supplements.
There was a synergistic interaction between depression or apathy and APOE ε4 in further elevating the risk of incident dementia.
There was a systemic error in classification based on hematocrit value.
There was a tendency to an impaired PPI in female premutation carriers at the @number@ ms condition.
There was a tendency toward improvement in the Stroop-color naming test ( @percent@ completion time , p = @number@ ) .
There was a trend for a higher BMD in individuals with uniparental disomy.
There was a trend for amitriptyline to be superior to placebo at @number@ and @number@ weeks but this did not reach significance.
There was a trend for decreased survival in double mutant animals compared to mice developing c-MYC-induced tumors.
There was a trend of pH to decrease while viscosity decreases.
There was a trend toward higher PT in ballistic than in ramp contractions.
There was a trend towards an age-by-group effect in the left supramarginal gyrus and the right pre- and postcentral gyri.
There was a variable-specific asymmetry between legs but it was not related to leg dominance.
There was a V-shaped trend in the net period effect between @number@ and @number@
There was awareness about the risk of liver fluke infections from eating raw fish.
There was a washout period of @number@ weeks in between the treatment periods.
There was a weak correlation between menopause duration and low performance in the capacity to manipulate information ( central executive ) .
There was a weak correlation between PiB increases and decline in cognition when all groups were combined.
There was a wide inter-individual variability in plasma concentrations of THC.
There was a worsening in WAI ( p = @number@ ) without difference between the groups.
There was clear evidence of an association between penetrating brain injury and impaired cognitive function.
There was considerable heterogeneity in the definition and measurement of HA and PA.
There was considerable somatotopic variability in EPTs , especially in the lower limbs.
There was consistent evidence that more women than men walk for leisure , although effect sizes were small.
There was decreased expression of glial glutamate transporter in the majority of tau-positive astrocytes.
There was discrepancy in @number@ patients using the new cut-off point ( ≥11 for Mild Cognitive Impairment vs ≤10 for dementia ) .
There was either no significant difference in PCSK9 levels during the menstrual , ovulatory , luteal phases in the @number@ healthy fertile women.
There was enormous heterogeneity in these studies , and reporting of harms stratified by age is lacking.
There was equivocal evidence of carcinogenic activity of beta-myrcene in female B6C3F1 mice based on marginally increased incidences of hepatocellular adenoma and carcinoma.
There was equivocal evidence of carcinogenic activity of beta-myrcene in female F344 / N rats based on increased incidences of renal tubule adenoma.
There was evidence for a higher rate of false recollection of rearranged pairs following exact repetition of study pairs in older but not younger adults.
There was evidence of a cumulative effect of LTPA across mid-life on grip strength at 60-64.
There was evidence of an interaction between age and ICD treatment on survival ( two-sided posterior tail probability of no interaction < 0.01 ) .
There was evidence of positive associations with both ischemic heart disease and stroke and effect modification by age , with shallower associations at older ages.
There was evidence of reappraisal processes for avoidant but not anxious attachment.
There was evidence that PWS and PWS + S ingestion promoted greater changes in REE responses.
There was female preponderance of cases ( @percent@ ) .
There was further reduction of @number@ hmC in tumor tissues when tumors were developed.
There was Gaussian distribution variation in the optic center allocation in each simulation.
There was greater moderate functional impairment based on Barthel ADL in the acromegaly group than in the CG ( p = @number@ ) .
There was heterogeneity in ways of defining and measuring mobility limitation in older adults living in the community.
There was high concordance between the first and second trials for both the 3-m and 6-m courses.
There was higher expression of genes involved in fatty acid synthesis ( FASN and PPARγ ) during the first 24h of recovery.
There was higher proportion of alcoholic and hypertriglyceridemic AP in men than in women.
There was however a case report of @number@ siblings in the University of Benin Teaching Hospital , Benin City , Nigeria in @number@
There was , however , a non-significant trend towards a reduction in carer burden over the course of the intervention for both gallery groups.
There was , however , little understanding or planning regarding the potential health impacts of heat.
There was , however , no correlation between the various platelet function tests.
There was , however , no presence of amyloid-beta deposits.
There was increased GFAP immunoreactivity in decades @number@ and @number@ in comparison to decade @number@ in the CN.
There was increasing proportion of older adults not living well with chronic disease as they aged.
There was large variability in the protocols used ( e.g. number of sessions , intervention duration , outcome measures , and sample size ) .
There was least deviated bony pyramid and most deviated lobular in the unilateral cleft lip deviated nose.
There was less reliance on informal teaching and improved assessment : teaching ratios compared with the @number@ survey.
There was little agreement between self-reported hypertension and hypertension identified by blood pressure measurement.
There was little association between shift work and average cognition in later life or between shift work and cognitive decline.
There was little change in average age at death over @number@ years , and death was earlier the more severe the level of intellectual disability.
There was little difference in ICC profiles by genomic region and probe type.
There was little effect of diet or generation on phenotypic markers in day @number@ adults.
There was little evidence of associations between the other cortisol measures and cognitive function.
There was little evidence of associations with balance or grip strength.
There was little evidence that specific measures put either group at particular advantage or disadvantage and little evidence of cognitive test bias in this sample.
There was little evidence that these associations varied by age group ( p = 1.00 ) or cell type ( p = 0.29 ) .
There was little relation between either HAZ or stunting and adult health.
There was little theta-band activity meeting the BOSC method's criteria , suggesting prior findings of theta power in healthy aging may reflect non-rhythmic signal.
There was low awareness among home-care assistants about the content of the statutes of delegation.
There was low prevalence of sexual behaviour in unpartnered participants , limiting further stratification.
There was marked variability in response to histamine within individual adults , depending on the locale of the tests.
There was minimal coexpression of p75NTR with ATF3 , a marker for cell stress , but @percent@ coexpressed the apoptotic marker cleaved caspase-3.
There was mixed evidence for a relationship between bereavement and physical activity.
There was moderate concordance between the FP and FI ( κ = @number@ @percent@ confidence interval ( CI ) @number@.36-0.49 ) .
There was moderate-quality evidence to assess mobility or disability and very-low- to low-quality evidence for using a multicomponent instrument to predict mortality or MACCEs.
There was moderate- to high-quality evidence for assessing mobility to predict mortality or functional status.
There was negative association between underweight , and hypertension and diabetes.
There was negligible probability for moving from high to low utilization category.
There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline.
There was neither an age-related decrease in activation extent , nor any qualitative shifts in activated areas as suggested by the focalization hypothesis.
There was no additional benefit to speaking more than @number@ languages.
There was no age difference in the frequency of responding with the former prime response in control trials.
There was no age interaction with these findings.
There was no age- or Alzheimer-related alteration in total amyloid-β content within this region.
There was no age-related difference in normalized lumbar flexion angles corresponding to different event times of erector spinae activity.
There was no apparent circadian rhythm.
There was no association among @number@ women reporting surgical menopause.
There was no association between age and gender in patients with abnormal tympanograms and absent acoustic reflex.
There was no association between a testosterone / estradiol imbalance and an alteration in erectile function and sexual desire.
There was no association between baseline prediabetes and disability [ OR = 1.27 ( @percent@ CI @number@.91-1.78 ) ] .
There was no association between blood lead concentration and LTL.
There was no association between cases with hippocampal sclerosis associated with ageing and apolipoprotein E genotype.
There was no association between change from baseline amount of energy consumed per FCI item and change in cravings.
There was no association between CHD and LTL in AfAm.
There was no association between chronological age and attention performance.
There was no association between depressive symptoms and food intakes of these vitamins or folate.
There was no association between diastolic BPV over 8years with GAD or depression.
There was no association between health literacy and self-care confidence ( Rs = @number@ P = @number@ ) .
There was no association between longitudinal Aβ1-42 levels and standardized uptake value ratios during follow-up.
There was no association between MeDi and white matter hyperintensities.
There was no association between n-6 PUFAs and the risk of incident mobility disability or gait speed decline.
There was no association between pre-frailty or frailty with falls.
There was no association between relative vegetable protein intake and change in physical performance measures.
There was no association between sclerostin and injury duration in subjects with long-term SCI ( > 5 years post-injury ) .
There was no association between SIRT1 SNPs and the serum-induced SIRT1 assay.
There was no association between SVH and low bone density.
There was no association between the Apo E genotypes and the MetS.
There was no association between the degree of PC loss and the severity or the duration of ET.
There was no association between the risk of SZ and rs707284.
There was no association between t-PA and decrease in CBF.
There was no association between upper leg lean tissue mass and functional performance ( r = ≤0.06 ) .
There was no association of AII with hypertension , diabetes mellitus , or hyperlipidemia.
There was no association of AWP with genotype , atopy or concomitant drug intake.
There was no association of \ "meat-fish \ " pattern or the MDS with risk of cognitive impairment in women.
There was no association of neuropathy with PD duration.
There was no association with albuminuria.
There was no association with diabetes.
There was no association with mortality for sedentary time or light or moderate-to-vigorous activity in highly active adults.
There was no case of pulmonary aspiration.
There was no change in mucociliary clearance during any of the treatment periods.
There was no change in negative social interaction rate over time ( estimate = @number@ SE = @number@ p = @number@ ) .
There was no change in the density of microglial cell bodies in gray matter during ageing or AD.
There was no change in the systolic or diastolic blood pressure during the stimulation.
There was no clear evidence of chemical bonding and the bond strength between zirconia and porcelain was lower than that between metal and porcelain.
There was no concurrent association of cortical Aβ load with cognitive performance or brain atrophy.
There was no consistent relationship between sclerostin levels and trabecular bone parameters in either sex.
There was no correlation between age , educational level and emotional reactions.
There was no correlation between associated conditions and postoperative mortality rates between the two groups.
There was no correlation between BP changes and changes in body composition and REE.
There was no correlation between cytosine-adenine-guanine ( CAG ) repeat length and REM sleep.
There was no correlation between ED groups regarding LUTS severity ( p = 0.303 ) .
There was no correlation between MMP-3 expression and age , gender and duration of the pain.
There was no correlation between PFM electromyographic activity and BMI.
There was no correlation between sex and FA in these regions.
There was no correlation between sweat chloride concentrations measured at the time of diagnosis and AWP score.
There was no correlation between time of aerobics and acoustic measures , but there was correlation of those measurements with age.
There was no correlation of iAβ between gender , postmortem interval , or age.
There was no cross-modal transfer of after-effects from voices to faces.
There was no death.
There was no decline in total energy intake after a decade.
There was no decrease in prescription rates for antipsychotics in older patients ( p = @number@ ) .
There was no difference between groups for depression , fatigue , or loneliness.
There was no difference between groups for mean grades regarding amount of wrinkles , beauty , harmony and symmetry.
There was no difference between professional caregivers and older people in the positive attitudes to ageing expressed as the growth potential.
There was no difference between sexes or ages.
There was no difference between the arms in median time to IC.
There was no difference between the Berlin questionnaire score and weight between patients with OSA and those without.
There was no difference between the groups in CCT , CC , AL or CRF.
There was no difference between the groups with respect to maximal force or mechanical properties.
There was no difference between the groups with respect to tendon cross-sectional area or tendon free length.
There was no difference between the @number@ groups in the number of necessary interventions , and no bleeding complications or POPF-related mortality occurred.
There was no difference between the provocative effects of action-programming and thinking NPA task groups as well as among individual NPA tasks.
There was no difference between the sarcopenic and non-sarcopenic groups in intervention adherence or number of adverse events.
There was no difference between the two groups of patients in the VCE completion rate ( @percent@ vs. @percent@ , P = 0.4 ) .
There was no difference between the young and middle-aged groups ( P = @number@ ) .
There was no difference in 15-keto-dihydro-PGF₂α levels between cases and controls.
There was no difference in adverse events between the two sides.
There was no difference in age-adjusted mortality rates in the frail group according to each definition ( @number@ vs 33 / 1000PY ) .
There was no difference in age distribution between @number@ older couples with DS and @number@ control couples.
There was no difference in any neuroimaging measure between CN subjects with and without head trauma.
There was no difference in apoptosis between the injured elderly subjects when compared with the NIE controls.
There was no difference in coagulation profiles between the frail and the non-frail amongst those taking warfarin.
There was no difference in Cortisol and Prolactin levels between groups.
There was no difference in DHEA level between the groups.
There was no difference in documenting cognitive function tests.
There was no difference in estimated glomerular filtration rate at @number@ months.
There was no difference in executive function , speed of processing , memory , motor skills , or total activity.
There was no difference in GDS scores between the patients with and without macrovascular complications.
There was no difference in hippocampal volume change or emission tomography between groups.
There was no difference in hospital stay between patients under and over @number@ years old.
There was no difference in ICU-LOS or in-hospital mortality between the two groups.
There was no difference in initial FEV1 levels between subjects with and without airway hyperresponsiveness.
There was no difference in meal duration and meal induced change in appetite at meal termination between test sessions.
There was no difference in mean IMT for individuals above or below the 75th percentile for CRP , TNF-α or IL-10.
There was no difference in motor function or any other cognitive domain.
There was no difference in neutrophil phagocytosis between the two groups.
There was no difference in overall mean cross-sectional area of the caudate tail between the two sides.
There was no difference in overall survival between the elderly and the younger.
There was no difference in poor outcome rates between lobar and deep locations ( @percent@ versus @percent@ , P = @number@ ) .
There was no difference in prevalence of cerebral SVD between the central and branch RVO groups ( P = @number@ ) .
There was no difference in serum 25 ( OH ) D levels between patients with low intake and those with intermediate and high intakes.
There was no difference in serum or CVL cytokines between symptomatic and asymptomatic postmenopasual women.
There was no difference in telomerase activity between PTSD patients and healthy controls while telomerase activity was significantly lower in the elderly.
There was no difference in the code rate ( @number@ vs @number@ per @number@ patient days , P = @number@ ) .
There was no difference in the density of microglial cells or astrocytes in treated groups versus the control @number@ months after the treatments.
There was no difference in the duration of TPN administration , the rate of TPN line sepsis , serum electrolyte derangement or glycaemic control.
There was no difference in the FVC response to SNP between young and older men ( P > @number@ ) .
There was no difference in the I405V , C629A , and Taq1B polymorphisms between AD and control groups.
There was no difference in the impact of severe symptoms in different ages.
There was no difference in the models for females and males.
There was no difference in the number and size of islets or β-cells in the three types of mice , or evidence of β-cell proliferation.
There was no difference in the slope of this relationship between young adults and elderly subjects.
There was no difference in TL between the OSA and non-OSA ( control ) group.
There was no difference in weight change over admission between the groups.
There was no differences between groups in the amplitude or area under the curve of contractions.
There was no dose- or age-related modulation of the effects of caffeine on quantified electroencephalographic measures.
There was no downtime and no severe side effects reported.
There was no downtime associated with the procedure.
There was no effect of age on our results.
There was no effect of either MCI or healthy ageing on dual-task performance , indicating that the dual-task impairment is specific to AD.
There was no effect of handgrip intensity or age on total peripheral resistance.
There was no effect of smoking , gender , or iris colour on MPOD values.
There was no effect of Zometa on muscle attenuation or muscle CSA.
There was no evidence for publication bias.
There was no evidence of a cadazolid dosage-dependent response.
There was no evidence of an age-related decline on any tasks.
There was no evidence of an age-related positivity effect for low-arousal social scenes.
There was no evidence of an association between immigration status and service use.
There was no evidence of an increased risk of hospitalization for stroke after initiation of atypical antipsychotics.
There was no evidence of a significant treatment effect on behavioral and psychological symptoms of dementia.
There was no evidence of a U-shaped association.
There was no evidence of effect modification for the relationship between adult height and CAC by age or socioeconomic status.
There was no evidence of lagged / longitudinal relationships between depressive symptoms and cognitive functioning in older adults in treatment for MDD.
There was no evidence of mediation by THs for PFOA-neuropsychological function associations.
There was no evidence of publication bias.
There was no evidence that age modifies the association between ICD treatment and rehospitalization.
There was no evidence that alcohol or fruit intake was associated with any outcome.
There was no evidence that frequent engagement in volunteer activity was associated with heightened inflammation.
There was no evidence that hypertension or changes in hypertension increased dementia risk among men.
There was no evidence that nNOS-positive nerves contributed to vasodilation of feeding arteries in striated muscles.
There was no evidence that participant characteristics other than age accounted for reports of illusory changes.
There was no evidence that the association between pain and frailty was influenced by gender.
There was no evidence that this differed by type ( vascular versus non-vascular ) of cognitive disease.
There was no evidence that this risk changed either with BP type and regimen , or concurrent use of other drugs or previous hospitalizations.
There was no evidence to support stressful events or C-reactive protein as mechanisms of religious attendance.
There was no evidence to support the role of specific protein food sources , such as types of meat , on cognitive function.
There was no eyelash whitening in @percent@ of the subjects and no level @number@ eyelash whitening was detected in any subject.
There was no gender difference in terms of eyelash whitening level.
There was no grade @number@ toxicity of any kind.
There was no group difference between younger and older men ( P = @number@ ) .
There was no increased risk of death or morbidity compared to younger patients in the three groups examined.
There was no increase in any adverse events ( AEs ) or serious AEs compared with placebo.
There was no increase in the incidence of adverse events with this higher dose.
There was no independent association between insomnia symptoms and physical capacity.
There was no interaction between age and speed.
There was no interaction between OI and APOE ε4 and risk of dementia.
There was no interaction between PfS and social isolation on SI and SH.
There was no interaction between plasma total tau level and brain Aβ for prognosis with any outcome.
There was no interaction by sex and race on risk of developing dementia.
There was no interaction for femoral neck or total hip BMD.
There was no interaction in this effect.
There was no LGE in the age-matched veteran controls or young athletes.
There was no linear association between composite DES scores ( generated using latent class analysis ) and androgen levels.
There was no mortality in both groups.
There was no nondemented case with final MMSE score of @number@ within a year of life and Braak stage VI pathology.
There was no obvious change in other syndrome types.
There was no other association of these biomarkers with IR , MetS , and diabetes risk after full adjustment.
There was no racial difference in the association between these alleles and mortality.
There was no regeneration of skin adnexa.
There was no relation between the change in difficulty and presence or absence of maxillary incisor.
There was no relationship between AGA severity and metabolic syndrome ( p = @number@ ) .
There was no relationship between inner retinal layer thickness and sex , anterior chamber depth , optic disc area , or central corneal thickness.
There was no relationship between radiological evaluation of IVDD and aging.
There was no relationship between ST and age.
There was no relationship between these findings and the progression of age and socioeconomic classes.
There was no relationship between TNF polymorphisms and TNF levels.
There was no relationship between used food textures and nutritional status residents.
There was no release from informational masking for either age group.
There was no reproduction in the snails in any treatments including the reference during the exposure phase.
There was no risk of mobility disability or mortality with weight gain.
There was no scar contracture of incision of palm.
There was no sex difference in amyloid PET at any age.
There was no sex or age based difference in rhinovirus induced IP-10 expression.
There was no shown association of specific comorbidities to complications between the two groups.
There was no significant age ( p > 0.2 ) or BMI ( p > 0.7 ) difference between female and male participants.
There was no significant age-related difference in the overall rate of T cell immunity for the three pneumococcal proteins.
There was no significant annual change in scoliosis Cobb , thoracic kyphosis , and lumbar lordosis angles in the GMFCS level I-II and III groups.
There was no significant association between blood pressure and PD risk in men.
There was no significant association between CC and CH or CRF.
There was no significant association between dental caries and energy , macronutrient intake , and Ca / P ratio , respectively.
There was no significant association between glycemic status and hip geometry in men.
There was no significant association between Internet use and breast screening.
There was no significant association between LTL and age-at-menopause among non-Hispanic black women.
There was no significant association between MetS and absolute MVPA , MPA or VPA recommendations in the fully adjusted model.
There was no significant association between neighborhood Z-score and serum lycopene.
There was no significant association between OSA and hippocampal or entorhinal cortex volumes in our sample , even after controlling for intracranial volume.
There was no significant association between total and free serum testosterone levels and the total and subscale scores on either AMS or JAMQ.
There was no significant association between TREM2 carrier status and cognitive function or decline.
There was no significant association with processing speed or memory performance.
There was no significant change in hippocampal volumes , suggesting that forniceal changes may precede hippocampal age-related changes.
There was no significant change in volume between each of the follow-up time points.
There was no significant correlation between aLM index and zigzag walking time in men and women.
There was no significant correlation between BCVA , macular OCT profiles , and MPOD.
There was no significant correlation between changes in vertical facial development and a single cross-sectional IGF-1 measurement.
There was no significant correlation between eEF1A2 protein and mRNA expression levels.
There was no significant correlation between myocardial T2 and age ( R ( @number@ ) = @number@ P = @number@ ) .
There was no significant correlation between oral status and depression , just a trend.
There was no significant correlation between self-esteem and sex , body mass index ( BMI ) , physical exercise , HbA1c or parental educational level.
There was no significant correlation of the level of sclerostin with the degree of BP increase.
There was no significant cross correlation between hot flashes and activity levels.
There was no significant decay in the training effect over this time period.
There was no significant decrease for GABA + / Cr ratio.
There was no significant difference between groups formed by BMI and blood pressure.
There was no significant difference between muscle mass ( p = 0.25 ) and lean mass ( p = 0.26 ) .
There was no significant difference between the baseline and 1- to 5-year follow-up examinations.
There was no significant difference between the effect of NSO and ISCS on nasal burning and itching ( p > 0.05 for all ) .
There was no significant difference between the groups in physical activity , tobacco smoking and alcohol consumption or diet after the intervention.
There was no significant difference between the groups in Purkinje or granule cell number or density , and no overall difference in Purkinje cell gradient.
There was no significant difference between the groups in terms of severe adverse events.
There was no significant difference between the groups ( p = 0.13 ) .
There was no significant difference between the nasal side and the temporal side for epithelial thickness.
There was no significant difference between the @number@ groups in respect of the complications rates.
There was no significant difference between the score of the two groups or between these scores and the voice change perception.
There was no significant difference between the two groups.
There was no significant difference between the two groups as regards gender or type of CNV.
There was no significant difference between the two groups for HAM-D.
There was no significant difference between the two groups in Child-Pugh class and tumor stages.
There was no significant difference in ADC values between kidneys with and without VUR.
There was no significant difference in creatinine and cotinine levels between genders and age groups.
There was no significant difference in curvature pattern between adolescent and adult group.
There was no significant difference in %EFI scores in most age groups.
There was no significant difference in growth of the snails between treatments.
There was no significant difference in IL-10 expression among groups.
There was no significant difference in myopic shift between eyes that were operated on and those that were not.
There was no significant difference in subcortical atrophy and ventricular expansion between DLB and HC.
There was no significant difference in survival time between the cohorts in either ADL disabled persons or non-disabled persons.
There was no significant difference in the 1-year mortality rates between these groups ( @number@ vs @percent@ ; P = 0.3 ) .
There was no significant difference in the above two parameters of gait stability between middle-aged and older subjects ( P > 0.050 ) .
There was no significant difference in the baseline characteristics between @number@ groups ( P > @number@ ) .
There was no significant difference in the eNOS level between older people and children.
There was no significant difference in the extent of deamidation between cataract and age-matched normal lenses.
There was no significant difference in the gene expression related to inflammation between the @number@ groups.
There was no significant difference in the incidence of SNs between age groups ( ρ = @number@ ) .
There was no significant difference in the MMSE total score between women and men.
There was no significant difference in the mortality for SA between upper limb affected and lower limb affected.
There was no significant difference in the occurrence of HAIs based on room type ( p = @number@ ) .
There was no significant difference in the range of motion between the groups.
There was no significant difference in the rates of grades 3-5 toxicity , dose reductions , or delays with PDR.
There was no significant difference in the size of enrollment increases between states with and without concurrent limited Medicaid eligibility expansions.
There was no significant difference in the TFTs of each point among the age groups ( all P > 0.05 ) .
There was no significant difference in the type of fracture across the three groups ( p = @number@ ) .
There was no significant difference in thickness between the first postoperative appointment and the second postoperative appointment.
There was no significant difference in three moxibustion treatment groups ( all P > @number@ ) .
There was no significant difference in total daily dairy serving intakes by age decade ( 60-69 , 70-79 , > 80 yrs ) .
There was no significant difference in VSM scores between subjects classified as CDR @number@ and CDR 2-3 ( @number@ + / - @number@ ) .
There was no significant differences in the genotype frequency or allele distribution in other paired groups ( P > 0.05 ) .
There was no significant difference when patients were compared by gender , age , body mass index , or facial shape.
There was no significant effect of sex on gray and white matter asymmetry.
There was no significant effect of the intervention on folate status.
There was no significant effect on acute bioavailability or pharmacokinetics of major phytochemicals.
There was no significant evidence for curvilinear age trends in either study.
There was no significant excess of serious adverse events prespecified as being of special interest.
There was no significant gender difference in prevalence of Modic changes ( p = @number@ ) .
There was no significant gender-related difference in postexercise muscle elasticity.
There was no significant group × time interaction for GRF , OI and JH ( P = @number@ ) .
There was no significant impact on mortality.
There was no significant improvement in wrinkles in this study.
There was no significant increase in total and free PSA levels in the serum after DRE and TRUS.
There was no significant interaction between gender and PI cohort.
There was no significant interaction between speed×phase ; however , greater normalized muscle activity was seen for highspeed yoga across the entire session.
There was no significant interaction with age and serum testosterone level tested as continuous variables ( P = @number@ ) .
There was no significant loss of correction from postoperative to most recent follow-up.
There was no significantly difference of PCSK9 levels between the lower and the upper estradiol ( E2 ) tertiles in the @number@ women.
There was no significant Neighborhood Attribute × Driving Status interaction with objective physical activity or reported transport walking.
There was no significant post-exercise hypotension and carotid arterial compliance changes.
There was no significant relationship between entorhinal cortex volume and activation during intentional encoding in either group.
There was no significant relationship between HGS and hospital re-admissions.
There was no significant sex difference in CV mortality.
There was no significant variation between age , nutritional status or between groups.
There was no similar correlation for PCA.
There was no specific timeframe for collection of samples.
There was no statistical difference in these measures between the lens cortices and their respective lens nuclei.
There was no statistically significant age or gender effect.
There was no statistically significant association between hearing loss and hypertension after adjusting for age and DM.
There was no statistically significant association between other depressive symptoms or overall depression and mortality.
There was no statistically significant correlation between jaw opening force and maximum hyoid position in either men or women.
There was no statistically significant difference between the categories and subscales or the overall score.
There was no statistically significant difference between the prevalence of TMD in institutionalized and non-institutionalized individuals.
There was no statistically significant difference in any parameter between Ob and Lc cord blood.
There was no statistically significant difference in ILB height between males and females.
There was no statistically significant difference in the heart rate between the two groups.
There was no statistically significant difference in the rate of postoperative complications between patients aged 70-79 years and those aged ≥80 years.
There was no statistically significant relationship between thirst and HRQoL , which was low overall.
There was no statistically significant sex difference.
There was no statistically significant sex difference in T2 spatial variation in either group.
There was no suggestion for heterogeneity across cohorts ( P heterogeneity > @number@ ) .
There was no support for the hypothesis that impaired older adults who have more cognitive ability will have a higher rated quality of life.
There was not a clear trend for the spine-to-back skin distance and L1 vertebral angle.
There was not a significant interaction between midlife alcohol consumption status and APOE e4 on the trajectory of learning and memory.
There was not a significant interaction of bicarbonate with CKD.
There was not enough evidence to recommend the other interventions.
There was no treatment effect on reflex vasoconstriction at the BH4-perfused or Y + P-perfused sites.
There was no treatment-related death.
There was no treatment-related mortality.
There was no variation in the proportion of biphasic or multiphasic contractions with maternal age.
There wasn't any effect on the cell viability up to 50μg / mL of CMC-nHAp-AA nanocomposite.
There was @number@ patient with metastatic disease who received hormonotherapy and died @number@ months after diagnosis.
There was obviously sexual difference in the prevalence of TN ( males @percent@ , females @percent@ , resp. ) .
There was one case of disease-related mortality during follow-up among the adult patients.
There was one death at @number@ days postinfusion in the 200-million group.
There was one death , no unexpected severe adverse events , and no differences of severe adverse events between the treatment arms.
There was one inpatient fall in each group ( not associated with a STRIDE walk ) .
There was one study with a 2b level of evidence , one with 3b , and the remainder had level @number@
There was one wound infection and four unsatisfactory results.
There was only a slight decline in attention and language after visit @number@
There was only fair correlation ( κ = @number@ ) between responses on the two questions.
There was only moderate correlation between ventilation capacity and population size ( coefficient of determination ( R ( @number@ ) ) = @number@ ) .
There was only one case of ID and aneurysm of the PCoA , but from the ID.
There was reasonable stability in the physical activity measure over the @number@ time points ( Cronbach's α @number@ ) .
There was severe degeneration of Scarpa's ganglion in the case with XPA.
There was significant correlation between the c-peptide level and age of children ( r = @number@ p < @number@ ) .
There was significant decline in DCNVA in the 60s and 70s compared with the 30s ( P < .03 ) .
There was significant difference between two groups ( p < @number@ ) .
There was significant difference in life satisfaction between the good- and bad-health groups.
There was significant heterogeneity among the included studies.
There was significant improvement before and after treatment ( P < @number@ ) .
There was significant improvement in multiple radiographic parameters from preoperative to postoperative.
There was significantly difference compared with preoperative ( P < @number@ ) .
There was significant variation in stated patient pathways but some common themes.
There was some age or severity related DIF indicating somewhat unstable across different characteristics of group.
There was some evidence at the spine for shared genetic effects between cross-sectional and longitudinal BMD.
There was some limited evidence of ability to learn to compensate for memory difficulties and contradictory findings regarding improvement in everyday life.
There was statistical difference in the distribution of each syndrome type among each age period ( P < @number@ ) .
There was statistical difference in the distribution of each syndrome type ( P < @number@ ) .
There was statistical difference in the distribution of each syndrome type ( P < @number@ ) .
There was statistical difference in the distribution of each syndrome type ( P < @number@ ) .
There was strong agreement between self-report and informant-report data.
There was strong evidence that higher scores of self-rated health , psychological well-being and life satisfaction were associated with better health in older age.
There was substantial heterogeneity across studies and the information was insufficient to assess the risk of bias for most studies.
There was substantial within-person variability in absolute symptom severity.
There was suggestive evidence that moderately severe brain injuries are associated with cognitive impairments.
There was the subgroup without myocardial infarction of @number@ ( @percent@ ) patients admitted with the diagnosis of pulmonary edema.
There was variability in the H1 / H2 and ApoE alleles and biochemical features of tau protein.
There was variation in magnitude and ranking of population attributable risk ( PAR ) by age , sex and definition of disability.
There was wide variation in information needs regarding radiation therapy decision making.
There was wide variation in the overall ADR prevalence , from @percent@ to @percent@.
There were 717 ( @percent@ ) women and @number@ deaths of which @number@ [ @percent@ ] were cardiovascular related.
There were abundant dystrophic neurites , astrogliosis and synapto-dendritic damage in the neocortex and hippocampus of the higher expresser line.
There were additional questions for caregivers on the impact of caregiving on their life.
There were a few studies investigated whether it has affected bone tissue in women.
There were age- and sex-differences in the factors related to cognitive function , particularly on the working status and social participation.
There were also differences across the scenarios : Optimization was discussed most frequently with perceptual and cognitive difficulty scenarios.
There were also differences between countries for certain symptoms.
There were also differences in B-cells , with higher frequencies in R compared to NR.
There were also nonsignificant , but meaningful , improvements for the letter-digit ( @percent@ ) and Stroop tests ( @percent@ ) .
There were also no significant associations when protein intake was separated by source ( animal and vegetable ) .
There were also no significant differences in operating room time.
There were also no significant differences in operating room time.
There were also no significant differences in the hardness and the bonding strength of the HA film before and after thermal cycling.
There were also qualitative differences with older adults showing a greater propensity to stop the hand and adjust finger position before lifting objects.
There were also significant reductions in amplitude of the S-ABR at the onset.
There were a number of cases ( @percent@ [ 22 / 1726 ] ) which had > 2 factors assigned.
There were apparent relationships between the dynamic diameters and age , body surface area , weight , and height ( p < @number@ ) .
There were association signals with activity in all @number@ genes.
There were certain discrepancies between PET and autoradiographic findings , which seemed to arise from partial volume effects ( PVE ) .
There were consistent associations between REV-ERB-ALPHA1 genotype and obesity-related traits ( p < @number@ ) .
There were differences in the intensity of depressive symptoms in the examined men ( p > @number@ ) .
There were different etiology proportion of AP according age , sex , and severity.
There were equivalent rates of eclosion success among larvae from eggs that matured in CB and water environments.
There were fewer admissions to intensive care ( P = 0.024 ) in the epidural anesthesia group.
There were fewer discrepancies in moderate or severe dementia.
There were few studies that indicated the importance of strengthening social movements that elicit discussion related to the elderly in Brazil.
There were four clinical leaks ( 3·3 per cent ) managed by laparoscopic drainage and placement of a feeding jejunostomy.
There were gender differences in renal function.
There were higher correlation coefficients between items and their hypothesized domains than other domains ( P < @number@ ) , indicating good content validity.
There were higher levels of uric acid and creatinine in AF patients.
There were higher utilization levels among IDS-TILDA participants for allied health and general practitioner visits.
There were highly significant differences between group A and groups B and C ( p < @number@ for each ) .
There were , however , age effects relating to involuntary eye movements.
There were , however , significant differences between the AD patients and both control groups in several of the memo-BNT measures.
There were increases in the prevalence of overweight that were greater than the reduction in the prevalence of underweight among Chinese elderly people.
There were interference-related increases in activity , involving fronto-parietal and basal ganglia networks that generalized across age.
There were late complications ( starting one month after the intervention ) in @number@ patients ( @percent@ ) .
There were mixed feelings about being dependent on assistance ; it interferes with self-sufficiency at a time of health transition.
There were more CCR4 ( + ) and CCR4 ( - ) Tregs in the elderly than the young.
There were more instances of agreement on disease presence and fewer instances on disagreement ( p = 0.001 ) .
There were more osteoporotic women among sarcopenic subjects ( @percent@ ) than among non-sarcopenic subjects ( @percent@ ) ( p-value = 0.011 ) .
There were more postoperative hallucinations ( p = 0·01 ) and nightmares ( p = 0·03 ) with increasing ketamine doses compared with placebo.
There were multiple relationships among cytokines and cognition , which varied over time.
There were negative relationships between calculated free testosterone ( cFT ) and HbA1c ( r = @number@ p < @number@ ) .
There were no adverse events in either of the two groups throughout the whole experiment.
There were no adverse events reported that were related to study product and reports of cutaneous tolerability issues were rare.
There were no age differences for luminance effects.
There were no age differences in monitoring this difference despite an age difference in memory.
There were no age differences in the recall of important information in Experiment @number@ but age differences were present for less important information.
There were no age differences regarding secure , avoidant , and dismissing attachment.
There were no age-related differences in femur volume.
There were no APOE group differences in DTI for any ROI.
There were no association between education and APOEe4 and cerebellar volume or cerebellar atrophy across the diagnostic groups.
There were no associations between anticipated survival and change in alcohol consumption.
There were no associations between any measure of dietary intake and balance in the women studied.
There were no associations between any of the derived dietary patterns and capillary recruitment.
There were no associations between beta-amyloid , alpha-synuclein , or TDP-43 and causes of death.
There were no associations between biological sex and gender roles.
There were no associations between paternal age and metabolism in any group.
There were no associations with baseline or change in lipid profile components with SBI.
There were no associations with four other measures of cognitive function.
There were no associations with SPSA that were significantly higher in the O-O versus Y-O group.
There were no between-group differences in any of the measures ( all p > @number@ ) .
There were no between-group differences in any of the variability measures ( P > @number@ ) .
There were no between-group differences in changes in self-reported pain.
There were no between-group differences in fiber tract diffusion parameters.
There were no between-group differences in pathological features , except for myometrial invasion and the rate of positive pelvic lymph nodes.
There were no cases of ID in fetuses.
There were no cases of persistent postoperative lagophthalmos or dry eyes.
There were no cells with an intermediate volume between amplifying and mature myocytes.
There were no changes after training in maximal EMG and isometric peak torque.
There were no changes in fat-free mass although body fat increased minimally ( @number@.0-1.5% ) .
There were no changes in femoral neck BMD in both groups.
There were no changes in maximal voluntary contraction or functional performance.
There were no changes in other common serum biomarkers assessing endocrine and exocrine pancreatic function.
There were no changes in total lean mass and total bone mineral density in both groups.
There were no changes to the internal structure of the enamel.
There were no clinical events attributable to recurarization.
There were no clinically meaningful differences between PDP and RHP enrollees in duration of therapy or medication possession ratio for any drug class.
There were no clinically meaningful findings in safety parameters.
There were no clinical signs of the tuberous sclerosis complex ( TBC ) or renal AML.
There were no complications such as secondary scoliosis , screw loosening , internal fixation failure and cage slippage.
There were no correlations between alpha1-ACT , transferrin , and adrenal androgens.
There were no correlations between ischemic lesion volumes and EPA , DHA , or EPA + DHA.
There were no correlations between kind of chronic disease and PMS , NHP , FIM ( p > 0.05 ) in either of genders.
There were no correlations between visual acuity and age or macular thickness.
There were no demographic predictors of higher empathy scores.
There were no detectable correlations between the neuroimaging measures and measures of cognition.
There were no differences according to laterality in either group ( p > 0.05 ) .
There were no differences between cases and controls in levels of interferon-γ , tumor necrosis factor-α , adiponectin , or insulin.
There were no differences between groups at the time of enrollment.
There were no differences between groups II and III for any of the measurements.
There were no differences between groups in gait parameters.
There were no differences between groups in time.
There were no differences between men with severe LUTS compared to men with mild or no LUTS ( all P values > @number@ ) .
There were no differences between the old active group and the young sedentary group.
There were no differences between the positive and negative word choices of the younger and older adults in the priming group.
There were no differences between younger and older participants in the sedentary energy expenditure and lying down duration.
There were no differences in baseline grip between baseline users and non-users of any drug class.
There were no differences in clinical documentation rates of delirium between African Americans and non-African Americans.
There were no differences in cognitive and executive function scores between groups at @number@ months.
There were no differences in cognitive decline between NIA-AA preclinical AD stages @number@ and @number@
There were no differences in diabetes , stroke and atrial fibrillation.
There were no differences in FC of resting-state networks.
There were no differences in grip force control between the age groups.
There were no differences in HbA1c , GFR , or albuminuria in the overall group.
There were no differences in hearing between groups of pilots.
There were no differences in MAP or other haemodynamic parameters , weight , urinary volume or 24-ABPM between SHU and controls.
There were no differences in muscle loss over time in patients grouped by median age or tumor type.
There were no differences in prevalence rate of SA between males and females.
There were no differences in safety parameters.
There were no differences in socioeconomic status , cognitive reserve , general cognitive status , or lipid and TSH profiles between the groups.
There were no differences in soluble or total amyloid-β levels.
There were no differences in steadiness between groups during an initial co-contraction trial ( P = @number@ ) .
There were no differences in the endothelium-independent vasodilation after ingestion of L-arginine.
There were no differences in the fibre type composition between the left and right muscle.
There were no differences in the memo-BNT test scores between the old and young control participants.
There were no differences in the prevalence of high-risk or low-risk telomere length between gravidity groups.
There were no differences in total neuronal size or count between subject groups.
There were no differences in total sleep time between groups.
There were no differential changes in the key indicators among the three ED clusters.
There were no direct effects of age and APOE on decline after accounting for these pathologic pathways.
There were no effects demonstrated with increasing age for intracellular magnesium , PDE or inorganic phosphate.
There were no effects of age or gender on MEP latencies.
There were no events of lid or brow ptosis.
There were no EWAS hits for the fitness traits.
There were no gender differences for inpatient hospital admissions and number of health conditions.
There were no gender differences for vision.
There were no gender differences in subjects aged 0-10 ( except on the canthus ) and those over @number@ years old.
There were no gender differences in the development of emotional autonomy.
There were no gender-specific differences in overall mortality.
There were no group differences for clinical and neuropsychological measures , and ApoE status.
There were no group differences in betting behavior.
There were no group differences in brain volume.
There were no group differences in GM volume.
There were no hemorrhagic or thromboembolic complications in a perioperative period except @number@ case of pulmonary hemorrhage and @number@ case of cerebral infarction.
There were no indications that side effects were more severe in elderly men.
There were no infections.
There were no instances of complications requiring dissolution of the product with hyaluronidase.
There were no instances of irritation , peeling or other apparent adverse side effects.
There were no interaction effects for dementia.
There were no intraoperative complications.
There were no intraoperative complications.
There were no notifications of locally-acquired malaria in Australia and @number@ notifications of overseas-acquired malaria during @date@ .
There were no other significant correlations between regional MRI volume and measures of neuropathology.
There were no other significant differences demonstrated.
There were no other statistically significant differences between age groups for the rest of the parameters.
There were no own-age biases for younger participants.
There were no patterns of AEs or SAEs.
There were no problems with screw extraction.
There were no publications examining dementia exclusively ; however , many subjects with dementia were included in studies of residential aged care facilities.
There were no radiological abnormalities such as pulmonary infiltrates and bronchiectasis by HRCT in all cases.
There were no randomized controlled trials targeted specifically to participants with silent cerebrovascular disease to prevent stroke.
There were no rebleeding events.
There were no recurrences of crow's feet during the follow-up period.
There were no relationships between hip proprioception error and postural sway during static stance.
There were no selection criteria on health or demographic characteristics.
There were no serious adverse events.
There were no serious adverse events reported in the RCTs.
There were no serious wound complications.
There were no severe adverse events.
There were no severe adverse events related to treatment.
There were no severe complications , i.e. aortic regurgitation , malignant arrhythmias , haemolysis or device dislocation.
There were no severe complications in the e-HCC group.
There were no sex differences in clamp responses with @percent@ protein.
There were no sex differences in dyspnea in the control group at any work-rate or ventilation ( V ( E ) ) .
There were no sex- or age-specific differences in compliance.
There were no significant adverse events , and no patients reported scarring.
There were no significant associations between clusterin and brain structures affected in later AD.
There were no significant associations between HIV disease variables or treatment variables and LPTA or HPTA.
There were no significant associations between liver and brain pathologies.
There were no significant associations between p16INK4a expression and cytokines.
There were no significant associations between slope or baseline level of CRP and cognitive decline nor between interleukin-6 and cognitive decline.
There were no significant balance differences between participants with and without CLBP within age groups during standing balance condition.
There were no significant between group differences on objective measures of executive function.
There were no significant changes in any measures in the control group ( p ≥ @number@ ) across the two testing sessions.
There were no significant changes in blood pressures or lipid profiles.
There were no significant changes in BMD or bone turnover markers.
There were no significant changes in neuronal volumes in either the anterior cingulate or orbitofrontal cortices.
There were no significant changes in performance across time , indicating initial training gains were maintained.
There were no significant changes in time trends for older adults in 2002-2012.
There were no significant correlation between hair As levels and BMD measurements.
There were no significant correlations between cytokine levels or fat and SP-HSC numbers.
There were no significant correlations between forearm MT and walking speed in either sex.
There were no significant correlations between MR osseous measurements and age , gender or physeal patency.
There were no significant correlations between ScoliScore and age , race , menarcheal status , Risser sign , or sex.
There were no significant correlations between the A30 : P70 and A50 : P70 ratios , and height and bodyweight.
There were no significant correlations for both groups between the IST and executive-function tasks.
There were no significant differences among the intervention groups on the other cognitive tests or domain scores.
There were no significant differences as regards self-comforting regulation.
There were no significant differences between asthma prevalence in studies which ascertained cases by written and video questionnaires.
There were no significant differences between BDNF Met + and Met- groups on either hippocampal volume or memory in either cohort.
There were no significant differences between cytokine and ex-mRNA responses of CD4-Tms from the old compared to the young subjects.
There were no significant differences between genders for S2PD and M2PD measurements.
There were no significant differences between groups on PFM MVC or straining.
There were no significant differences between men and women.
There were no significant differences between straw flow or straw type and sex of the participants.
There were no significant differences between the groups in these parameters.
There were no significant differences between the products in the Wrinkle Severity Scale scores and Evoked Compound Muscle Action Potentials.
There were no significant differences between the %SUV values of the AD patients and age matched control subjects.
There were no significant differences for texture discrimination.
There were no significant differences in APV and PWV between the PD and HD patients.
There were no significant differences in body composition , leg strength , blood lipid components and testosterone.
There were no significant differences in cognitive performance between PiB ( + ) and PiB ( - ) elderly.
There were no significant differences in complication rates or 90-day mortality.
There were no significant differences in daily energy consumption , physical activity and nutritional intake.
There were no significant differences in depression and social functioning between persons judging their voices to be good versus bad.
There were no significant differences in efficacy between Ret and Tret in these efficacy parameters.
There were no significant differences in femur neck and femur total T and Z scores between two groups.
There were no significant differences in headache severity or duration between amitriptyline and placebo groups at anytime during the study.
There were no significant differences in intraoperative blood loss , conversion to open surgery , and bleeding-related complications.
There were no significant differences in length of stay , delirium , or number of infections between the groups.
There were no significant differences in LF thickness with respect to gender ( P > @number@ ) .
There were no significant differences in major complication rates or 90-day mortality.
There were no significant differences in mean ODT scores between men and women.
There were no significant differences in mean time to reepithelialization between Obagi Nu-Derm System and control groups.
There were no significant differences in MF and MPF slopes of elderly men and elderly women.
There were no significant differences in protein level for the downstream survival kinase-signaling proteins Erk and phospho-Erk among groups.
There were no significant differences in quiet eye duration across the skill or age groups in either task.
There were no significant differences in sitting time by body mass index for males.
There were no significant differences in subjects from either group in clinical or biological variables.
There were no significant differences in the demographic characteristics of patients with MD and AD.
There were no significant differences in the location or time of falling , but there were different risk factors and consequences in injury severity.
There were no significant differences in the number of hospital admissions , intensive care or ward treatments , or duration of hospitalization.
There were no significant differences in the osteocalcin levels before and after treatment in all the groups.
There were no significant differences in the percentages of patients with comorbidities or those with postoperative complications.
There were no significant differences in the rates of neurological decline among never smokers , former smokers , and current smokers.
There were no significant differences in the sleep measures between men and women.
There were no significant differences in the use of antiplatelet agents between patients with major indications for PA and those without major indications.
There were no significant differences in total hippocampal volume and no significant effects on gray-matter volume in women who received placebo or 1-mg estradiol.
There were no significant differences in variability across age strata.
There were no significant differences in width and height between the left and right facet joints at the same level by sonography.
There were no significant differences in β and blood pressure parameters between genders.
There were no significant effects of medication on cortical thickness , nor was there any significant sex-by-group interaction.
There were no significant effects on fear of falling or self-reported quality of life.
There were no significant immediate or delayed complications following treatment with any of the dermal fillers used.
There were no significant independent associations between high burden and high calls , high visits , or social work involvement.
There were no significant interaction or between-group differences and no significant changes in muscle cross-sectional area or health status were observed.
There were no significant interactions between APOL1 and income.
There were no significant interactions between either estimated NEAP or PRAL and total calcium intake.
There were no significant interactions of linear age effects with rate of cognitive decline.
There were no significant main effects or interactions for RTIPE or gender in any analysis ( all P > @number@ ) .
There were no significant race / ethnic differences in the odds ratio of fracture by BMD.
There were no significant relations between MSNA and LV mass , LVEDV or LVESV.
There were no significant relations of coffee intake to BP or pulse pressure in women.
There were no significant sex-related differences in any of the pharmacokinetic parameters.
There were no significant treatment differences in pain at either follow-up.
There were no significant univariate interactions between schooling group or age cohort and cognitive change over time.
There were no statistical differences between the groups.
There were no statistical differences between the young and old groups in the expression of CEA , MMP-2 , or p27 ( kip1 ) .
There were no statistical differences in gender distribution , tumor sites , tumor size , or gross type between the young and old groups.
There were no statistically significant associations between BMD and LTL ( both logarithmically transformed ) with or without age adjustments.
There were no statistically significant differences among the groups.
There were no statistically significant differences among the groups regarding electrical potential frequencies , durations and amplitudes of electromyographic recordings.
There were no statistically significant differences between the two groups in total number of falls at the @number@ month follow-up.
There were no statistically significant differences in adverse effects , length of hospitalisation or mortality.
There were no statistically significant differences in baseline characteristics.
There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not.
There were no statistically significant differences in DBC-A total scores between the different BMI categories.
There were no statistically significant differences in resting muscle activity , maximal voluntary contraction , and sustained contraction between women with and without dyspareunia.
There were no statistically significant differences in results of the different outcomes between patients receiving telemedicine and traditional follow-up.
There were no statistically significant differences in the angles between the central axis of the cochlea and these coordinate planes among age groups.
There were no statistically significant differences in the rates of hospitalization or death after correcting for multiple comparisons.
There were no strong correlations between tear film measures and androgen levels.
There were no studies identified that specifically examined \ "youth friendly \ " care for YLHIV within the context of adult clinical sites.
There were no treatment-related adverse events.
There were not statistically significant differences in parameters studied before and after treatment with both Pegaptanib sodium and Ranibizumab , except C-Reactive Protein.
There were @number@ AIDS and @number@ non-AIDS deaths at @number@ years , and @number@ AIDS and @number@ non-AIDS deaths at @number@ years.
There were @number@ all-cause ( @number@.3 / 1000 person-years ) and @number@ HF-related ( @number@.4 / 1000 person-years ) hospitalizations after HF development.
There were @number@ and @number@ injurious falls ( p = @number@ ) in the intervention and control groups , respectively.
There were @number@ arms with vildagliptin , @number@ with sitagliptin , @number@ with saxagliptin , @number@ with linagliptin and @number@ with alogliptin.
There were @number@ AUGS members available for every @number@ million women and @number@ AUGS members for every @number@ million postreproductive-aged women in the United States.
There were @number@ cases with α-synuclein positive Lewy bodies in the brainstem , and all of these cases presented parkinsonian motor dysfunction.
There were @number@ categories for this variable : no fall , falling once , and falling more than once in the past @number@ months.
There were @number@ cognition assessments with median follow-up time of @number@ years.
There were @number@ controlled hypertensives and @number@ normotensives.
There were @number@ deaths.
There were @number@ deaths from HCC among @number@ individuals , ascertained by validated death certificates and the national death registry.
There were @number@ deaths including @number@ CVD-related deaths during the follow-up period.
There were @number@ deaths over a median follow-up of @number@ years.
There were @number@ delirium cases according to the reference standard.
There were @number@ effective participants in the study.
There were @number@ elderly people aged @number@ years or over recruited in @number@
There were @number@ ESRD events and @number@ deaths.
There were @number@ ET cases and @number@ age-matched controls free of dementia and other neurodegenerative disorders included in the study.
There were @number@ falls reported.
There were @number@ females ; @number@ males.
There were @number@ genes significantly were associated with inflammatory ∆Age ( Colorectal cancer ( CRC ) is a leading cause of cancer-related mortality.
There were @number@ genes that showed differential expression with age in both skin and brain tissue and three common to adipose and brain tissues.
There were @number@ incident cases of IFG and @number@ incident cases of diabetes.
There were @number@ incident ET cases.
There were @number@ incident fractures ( @number@ nonvertebral and @number@ vertebral ) over a mean of @number@ ± @number@ years.
There were @number@ individuals for whom data on disability status at follow-up were available.
There were @number@ long-stay residents in @number@ facilities enrolled in OPTIMISTIC between @date@ and @date@ .
There were @number@ male and @number@ female , aging from @number@ to @number@ years.
There were @number@ male and @number@ female aging from @number@ to @number@ years.
There were @number@ male and @number@ female , aging from @number@ to @number@ years ( mean age , @number@ years ) .
There were @number@ male and @number@ female , aging from @number@ to @number@ years ( mean age , @number@ years ) .
There were @number@ male and @number@ female patients , aging from @number@ to @number@ years.
There were @number@ male and @number@ female patients , aging from @number@ to @number@ years.
There were @number@ male and @number@ female patients , aging from @number@ to @number@ years.
There were @number@ male and @number@ female patients , aging from @number@ to @number@ years with a mean age of @number@ years.
There were @number@ male and @number@ female patients aging from @number@ to @number@ years with a mean of @number@ years.
There were @number@ males and @number@ females , aging from @number@ ∼ @number@ years with a mean of ( @number@ ± @number@ ) years.
There were @number@ males and @number@ females , aging from @number@ to @number@ years.
There were @number@ males and @number@ females , aging from @number@ to @number@ years and with an average of ( @number@ ± @time@ ) years.
There were @number@ males and @number@ females , aging from @number@ to @number@ years old.
There were @number@ mice in each group.
There were @number@ nondemented participants and @number@ ( @percent@ ) with a diagnosis of dementia , with complete data for the analysis.
There were @number@ notifications of dengue virus infection locally-acquired in North Queensland and @number@ notified cases resulted from overseas travel.
There were @number@ ( @number@ % ) and @number@ ( @number@ % ) prevalent cases of CKD and cognitive impairment , respectively.
There were @number@ ( @number@ % ) hernia recurrences , @number@ requiring additional repair and @number@ requiring PADM explantation.
There were @number@ Nursing Interventions in the nursing records and seventeen of them related to skin and wound care.
There were @number@ observational studies and @number@ interventional studies.
There were @number@ of @number@ PLWH who met our eligibility criteria to participate in the survey ; @number@ responded.
There were @number@ of the @number@ recorded deaths caused by CVD among the @number@ participants.
There were @number@ older subjects ( ages 47-87 ) at two sites ; a small cohort of younger subjects served as controls.
There were @number@ pairs of matched cases and controls in our study.
There were @number@ participants ( @percent@ ) with dementia , @number@ of which were classified as probable AD.
There were @number@ patients and @number@ patients who had sufficient data to determine CFS and FI-lab scores , respectively.
There were @number@ patients ( average age : @number@ years ) treated in two university hospitals between @number@ and @number@
There were @number@ patients had been hospitalized because of trauma.
There were @number@ patients in the control group and @number@ patients in the experimental group.
There were @number@ patients in the good-stability group and @number@ in the poor-stability group.
There were @number@ patients ( @percent@ ) who died.
There were @number@ patients with isolated postural orthostatic tachycardia syndrome.
There were @number@ patients without deviated and @number@ patients with deviated.
There were @number@ ( @percent@ ) deaths over a median follow-up time of @number@ ( @number@.4-8.0 ) years from weight / WC reassessment.
There were @number@ ( @percent@ ) nonfrail , @number@ ( @percent@ ) prefrail , and seven ( @percent@ ) frail participants at baseline.
There were @number@ ( @percent@ ) participants with the ε4 allele.
There were @number@ ( @percent@ ) patients older than @number@ years , and @number@ ( @percent@ ) patients aged from 18-64 years.
There were @number@ ( @percent@ ) whites , @number@ ( @time@ % ) blacks , and @number@ ( @percent@ ) other.
There were @number@ reported mass formations , @number@ of which were infectious in nature.
There were @number@ research subjects in our study : @number@ cancer patients and survivors and @number@ controls matched using propensity scores.
There were @number@ SE in elderly patients.
There were @number@ senior adults aged 60-69 years living in urban , suburban , and rural areas of Shanghai City.
There were @number@ shunt revisions in the 1st year of life , which represents a rate of @number@ revisions per patient in that year.
There were @number@ strokes and @number@ TIAs in prospective follow-up ( median @number@ years ) .
There were @number@ subjects per age decade up to @number@ yr and @number@ subjects in the age group > 70 yr.
There were @number@ treatment-seeking patients recruited from four addiction treatment clinics in Sweden.
There were @number@ treatments over @number@ visits , with an average of @number@ visits per patient and @number@ treatments per visit.
There were @number@ women and three men with medium to deep nasolabial folds.
There were numerous reports on physical function in aging in a cross sectional or a longitudinal study design.
There were obvious changes in ultrastructure of fibroblasts , compared with the control group.
There were @percent@ ( 733 / 1300 ) women had ever heard ( mostly from gynecologist ) about hormone replacement therapy from Obstetrician and Gynecologist.
There were @percent@ ( @number@ @number@ ) of the Shanghai adults never took physical activity.
There were positive correlations between absolute thresholds and TFS-IPD thresholds , but not envelope-IPD thresholds , when age was accounted for.
There were positive crude mortality rate net changes for overall female cancer , breast and prostate cancers , which were primarily attributable to demographic changes.
There were remarkable decreases in midpupil lid distances in the temporal sectors of the lid fissure with aging , especially at the lateral canthal end.
There were revealed both : decrease and increase of some elements ' contents.
There were several randomized controlled trials , although most studies used less rigorous methods.
There were sex-specific and age-specific differences in these diseases.
There were significant 24-h circadian rhythms of both hot flashes and activity levels.
There were significant area differences in the PAR of how specific chronic conditions influenced the risk of disability.
There were significant associations between menopause stage and CST ( P = @number@ ) and between VVA and CST ( P = @number@ ) .
There were significant associations between morningness and sleep latency , sleep efficiency , and insomnia.
There were significant changes in IMT , MVEL , E / A , CYSC and FIB among aging groups in different age groups.
There were significant changes with aging and a decrease in flow speed with the NBS.
There were significant differences between children aged 3-5 years and the other age ranges for F0 mean for sustained vowels and F0 variability.
There were significant differences between group A and other groups.
There were significant differences between group C and groups A and B ( p < @number@ for each ) .
There were significant differences between measurements taken at rest and during the Valsalva maneuver in all age groups.
There were significant differences between skill groups and age groups in throwing accuracy on both throwing tasks.
There were significant differences between the NC , aMCI and AD groups in terms of both right and left hippocampus MK values.
There were significant differences between the @number@ groups in disease onset and aggravation , and intraoperative blood loss.
There were significant differences between young and old voices for SFF and L ( eq ) in both levels.
There were significant differences in both CyPA and CD147 expression among @number@ groups ( P < 0.05 ) .
There were significant differences in EDV among @number@ aging groups in @number@ age groups.
There were significant differences in patient characteristics between drugs and indications.
There were significant differences in PPI between premutation carriers with FXTAS and controls at PPI @number@ ms , and at @number@ ms.
There were significant differences in T2 spatial variation between the two groups ( p < 0.05 ) .
There were significant differences in the levels of cholesterol , triglycerides , and glucose between these three groups.
There were significant group and developmental differences for dyadic and triadic competencies.
There were significant improvements in both total and cFT and in AMS scores after three months ( p < @number@ ) .
There were significant improvements in other obesity-related co-morbidity.
There were significant interactions by potassium excretion for circumferential strain.
There were similar differences across age groups for the MMSE , but not for the CDR-SB.
There were similar differences between the severe OA group and the older asymptomatic and moderate OA groups.
There were some weak associations between SIRT1 SNPs and arthritis , heart attack , deafness , and cognitive impairment.
There were statistical differences in the expression of MMP-1 and TIMP-1 between the age and degree of degenerative changes groups.
There were statistically significant differences between the delirium group and the non-delirium group in the incidences of the sodium and calcium disorders.
There were statistical significances between age and MMP-1 , and MMP-2.
There were striking regional differences in the average heights and the secular trends in height.
There were strong correlations ( range r = @number@.85-0.94 ) between DXA-derived aLM and estimated FFM , leg LM or TMM.
There were substantial differences in decay among the sediments tested , and decay rates were related to sediment characteristics.
There were substantial differences in total resource utilization and also in the balance between formal and informal care between Northern , Western and Southern Europe.
There were subtle differences in trajectory slopes by sex and APOE ε4 genotype , but not by education.
There were three filter conditions ( no filter , placebo filter , and yellow filter ) .
There were total of @number@ patients who visited out patients department.
There were two alternatives proposed that might avoid chipping of veneering porcelains.
There were two cases ( @percent@ ) of primary non-function in group @number@ and one ( @percent@ ) in group @number@
There were two perioperative deaths ( @percent@ ) .
There were two phases of data collection.
There were variations among the classes of teeth.
There were very few clinically important predictors of specific causes of death.
There were very few differences in the associations by age , race / ethnicity , gender , education , or income.
There were virtually no significant race differences in the rates of change.
The rewetting with chlorhexidine negatively influenced the bond strength of the preparation with the Er : YAG laser.
The RF current causes irreversible muscle fibrosis , which in turn provides long-lasting results.
The RF of ADC increased from @percent@ in 2000-2004 , @percent@ in 2005-2008 to @percent@ in 2009-2012 in patients born after @number@
The R function constrOptim is used to maximize the multinomial log-likelihood function subject to a linear inequality constraint.
The Rg1 anti-aging group showed more significant changes than the Rg1 -treated aging group.
The RGC number was significantly reduced in 24-week-old SOD1-deficient mice , although they were not in 8-week-old mice.
The RGN protein is an X-chromosome gene product , whose transcription is regulated by a myriad of hormonal and non-hormonal factors.
The RG presented more difficulty in lexical decision , not only for words but also for non-words.
The rheological analysis of fibroblast-populated collagen gels demonstrates that cell stiffening directly results in altered viscoelastic properties of the collagen matrix.
The Rhesus macaque ( Macaca mulatta ) is one of the best studied species of Old World monkeys.
The rhomboid protease PARL , an intramembrane cleaving peptidase in the inner membrane , regulates mitophagy and plays an ill-defined role in apoptosis.
The rhythms of activity across the 24-h sleep-wake cycle , determined in part by the circadian clock , change with aging.
The rib model was validated against human rib specimens and whole rib tests , under different loading conditions , with and without modeled fracture.
The richness of episodic detail comprising autobiographical events in young and older adults was assessed using the Autobiographical Interview.
The right arcuate fasciculus showed similar pattern but without significant FA changes.
The right cerebral hemisphere is preferentially involved in recognising at least some facial expressions of emotion.
The right eye was analyzed in all subjects.
The right hippocampus was larger than the left.
The right infarct group demonstrated slower gait speed and greater asymmetry compared to the left infarct group and controls ( p < @number@ ) .
The right internal carotid artery was imaged by using ultrasound to estimate CBF.
The right knee joint served as control.
The right orbit presented larger measures.
The right side of the cervical cord showed severe atrophy.
The right to leisure is recognized as a human right under the @number@ United Nations Universal Declaration of Human Rights.
The right transverse sinus was dominant in @percent@ of cases.
The right uncinate and right ILF fasciculus demonstrated significant reduction in RD , Trace and AD , with and without significant FA increase , respectively.
The ring B unsaturated estrogens are formed by an alternate steroidogenic pathway in which cholesterol is not an obligatory intermediate.
The RING domain is necessary for this pro-apoptotic function of TRM32 as well as being responsible for its E3 ligase activity.
The rinse decreased subcutaneous bacterial survival rates in the adult group.
The RI of ROMA hasn't been established yet.
The RI of the MLB interior was calculated assuming an RI value of @number@ for the cytoplasm from the literature.
The RIs and @percent@ confidence intervals were calculated by the robust method recommended by CLSI C28-A3 guideline.
The rise in human life expectancy has involved declines in intrinsic and extrinsic mortality processes associated , respectively , with senescence and environmental challenges.
The rise in life expectancy requires strategies to enable healthy ageing and the promotion of a high quality of life in old age.
The RISE showed satisfactory internal consistency ( α ≥ @number@ ) and adequate interrater reliability ( ≥.40 ) .
The rising number of newly insured young adults brought on by health care reform will soon increase demands on primary care physicians.
The rising prevalence of dementia will have an effect on acute care hospitals around the world.
The rising proportion of elderly people worldwide will yield an increased incidence of age-associated cognitive impairments , imposing major burdens on societies.
The risk-adjusted annual decline was @percent@ ( hazard ratio , @number@ [ @number@.97-0.98 ] ) and was similar across all age and sex-race groups.
The risk allele of rs2229116 was opposite from the original report.
The risk alleles of the shared SNPs were associated with expression changes in cis-genes.
The risk allele was defined as the allele associated with an increased risk for PCa in the literature.
The risk also increased with the number of QT-prolonging agents , especially in men.
The risk and costs of hip and non-hip fractures were derived from large primary and hospital care data sets in the UK.
The risk assessment of older individuals is briefly reviewed along with the differences between some intervention guidelines.
The risk assessment of patients undergoing rehabilitation showed the greatest changes in group II , which after rehabilitation were classified as low risk.
The risk-benefit ratio of diagnostic and therapeutic interventions tips precariously in older patients as many develop geriatric syndromes.
The risk-benefit ratio of statin use , specifically for primary prevention , should be carefully weighed , and further studies are warranted.
The risk can be amplified by high household chores load.
The risk during @number@ months of these adverse events increased with psychological or sedative drug use.
The risk effects were more expressed after 12-20 years rather than in earlier or later follow-up.
The risk factors for laparoscopic cholecystectomy , use of statins , and surgical outcome were analyzed.
The risk factors for long-duration sleep suggest that deteriorating brain health predicts elongated sleep duration in older men.
The risk factors for postoperative complications and prognostic factors were identified using the multivariate analyses.
The risk factors were categorised as relevant and amendable , relevant but non amendable , inconclusive or unsupported.
The risk for death was higher for frail people , but underlying cognitive impairment is a key component of the lower survival rate.
The risk for each cardiac event increased with increasing number of cardiovascular risk factors ( all P ( trend ) < @number@ ) .
The risk for SCI was significantly higher among cases than controls , particularly for those @number@ years of age and older.
The risk for unmet physical activity need was highest among people whose severe mobility difficulties restricted their outdoor physical activity.
The risk increased significantly while delirium was associated with these two baseline characteristics ( OR = 4.76 with P = 0.001 ) .
The risk is also higher among the youngest : @number@ for men and @number@ for women.
The risk is higher while the number of borderline and major CRFs much more.
The risk model may aid in risk stratification and future HF prevention strategies.
The risk of adverse drug reactions ( ADRs ) rises with increasing age.
The risk of a false positive assignment rose with the patients ' degree of comorbidity.
The risk of Alzheimer's disease ( AD ) is highly dependent on apolipoprotein-E ( apoE ) genotype.
The \ "risk of breast cancer in women increases with age \ " is a longtime misstatement that does not conform to statistical data.
The risk of cardiovascular disease increases with age , causing chronic disability , morbidity , and mortality in the elderly.
The risk of chronic diseases increases with age which may result in an increased need for pharmacological treatment : polypharmacy.
The risk of cortical cataract increased @percent@ ( @percent@ CI @number@.4%-8.3% ) when outdoor activity time increased every one hour.
The risk of cortical cataract increased @percent@ when outdoor activity time increased every one hour.
The risk of delirium appeared to be lower with hydromorphone or fentanyl , compared with other opioids.
The risk of dementia was elevated in MCI cases ( hazard ratio [ HR ] @number@ p < @number@ ) compared with CN subjects.
The risk of depression in older adults with ADHD was partly explained by serious conflicts.
The risk of developing dementia is associated with increasing age , lifestyle , and cardiovascular health.
The risk of developing preneoplastic lesions depends on the type ( strain ) of the microorganism.
The risk of disability by age for each individual ADL , IADL , and for mobility was assessed using Generalized mixed models.
The risk of driver death in @number@ model passenger vehicles was @percent@ lower than that in @number@ models and about half that in @number@ models.
The risk of drop-out was increased by the presence of osteoarthritis.
The risk of ED increased with increasing age and number of comorbidities.
The risk of ESRD was higher than the risk of death without ESRD for ages < 60 years , and independent of eGFR.
The risk of falls from height on a construction site increases under conditions which degrade workers ' postural control.
The risk of fracture increases with age due to the decline of bone mass and bone quality.
The risk of fragility fractures exponentially increases with aging.
The risk of having low AAI seems to be increased by aging and inflammation , whereas BMD was associated with high AAI.
The risk of hip dislocation could also be minimized by careful tissue preparation and appropriate suture technique.
The risk of hippocampal deterioration increases with the decline of gonadal hormone supply.
The risk of hospitalization for stroke progressively increased in the weeks leading up to first-time antipsychotic treatment.
The risk of inappropriate prescribing is high in this age group.
The risk of incident infarcts in men was higher than the risk in women ( @number@ @percent@ confidence interval , @number@.5-2.3 ) .
The risk of infections from indoor molds is low for healthy individuals.
The risk of ischemic stroke , a primary and disabling hazard of AF , also increases with advancing age.
The risk of major arrhythmias should also be addressed correctly.
The risk of malaria is also high during the postpartum period , although mechanisms underlying this susceptibility are not known.
The risk of malnutrition was present in @percent@ ( @percent@ men and @percent@ women ; p < 0.001 ) .
The risk of mortality , however , was higher for home care assisted PD patients.
The risk of mortality was associated with ≥2 organ failures.
The risk of overall cancer inevitably increases with advancing age.
The risk of periprosthetic infection has been reduced about @date@ by the use of silver surface coating.
The risk of radiation exposure initially delayed the medical response , prolonging the recovery efforts.
The risk of severe hypoglycemia likely represents the greatest barrier to T2DM care in the elderly.
The risk of skeletal events in older adults due to cancer therapy should be appreciated by all oncologists , geriatricians , and internists.
The risk of stroke in elderly women exceeds that of men and it is clear that in some settings estrogen can have pro-inflammatory effects.
The risk of sustaining a fall is particularly high in children and seniors.
The risk of these complications depends on presence of risk factors , and age is the most frequent and relevant one.
The risk of weight and WC loss was higher among edentulous participants than among dentate participants.
The risk remains elevated one year after the acute episode.
The risk score allowed stratification of participants into those with 40-year low ( @percent@ ) and high ( @percent@ ) dementia risk.
The risk score characterized patients into low- and-high risk subgroups for adverse events ( ≤10 points , @percent@ ; ≥30 points , @percent@ ) .
The risks of both increased LOS-T and LOS-H were related to age only ( P = 0.052 , P < 0.001 , respectively ) .
The risks of mortality associated with EOAD and LOAD were evaluated by Cox proportional hazard analyses , controlling for relevant covariates.
The risks of overdosing and underdosing are outlined , and some recommendations to reduce the risk of adverse drug reactions are provided.
The risks of polypharmacy and the potential for inappropriate therapy must be considered and balanced against the possible benefits of multiple drug therapies.
The risk that testosterone treatment would trigger prostate cancer was not fully recognized.
The risk traveling disability among people aged @number@ with two comorbidities increase from @percent@ to @percent@ at age @number@
The risk trend of unplanned hospitalization and intensive care unit admission is similar among the study population.
The risk was also higher for VFx in males ( HR : @number@ CI : @number@ @date@ , P : @number@ ) .
The risk was higher among First Nations people than among non-First Nations people for all index ages and for both sexes.
The risk was higher for adenocarcinoma patients possessing the XRCC3 Met / Met or XRCC1 Gln / Gln genotypes , although their frequency was small.
The RISTOMED diet was optimized to reduce inflammation and oxidative stress.
The RIs were determined following CLSI C28-A3 guidelines using a nonparametric method.
Thermal cycling is one of the most widely used procedures to simulate the physiological aging experienced by biomaterials in clinical practice.
Thermal energy is applied via the percutaneous route for ablation of selected facial muscles to modify the facial dynamics.
Thermal gravimetric analysis was performed on the ceramic primer.
Thermal lesion approach seems to provide better outcomes when applied to deep dermal layers.
Thermocycling did not decrease the results significantly in any of the groups ( p > @number@ ) .
Thermoregulation is limited in preterm infants.
Thermoregulatory capacities are strongly related to energy balance and animals are constantly seeking to limit the energy costs of normothermia.
The RNA studies confirmed aberrant splicing of exon @number@ and family studies showed that both parents are heterozygous for this mutation.
The RNPs increase significantly in size based on cytology ; their morphology and subcellular localization changes , and their composition changes.
The r ( @number@ ) of the estimated ASM was @number@
The roadmap was devised by identifying current evidence of validity , still missing evidence , and action needed to collect this missing evidence.
The ROA group had greater quadriceps intraMF fraction but not for other muscles.
The robot applied graded force perturbations , which produced small displacements of the handle.
The robot will allow the care provider to communicate remotely with the patient using audio and video equipment installed on the robot.
The robot will possess motion control capabilities to move inside the house of each patient and alert in case that emergency events occur.
The robust group was considered when they had zero conditions.
The robustness of the analysis is contrasted with alternative input-output models.
The robustness was further validated by using RevSS RedoxDB as independent testing dataset.
The ROC curve was used to select three different cut-points for each model and to compare classification.
The ROCF assesses visual perception , constructional praxis , and visuo-spatial memory.
The ROIs showed that the benefits not only covered the implementation costs but also exceeded the expected direct program delivery costs.
The role in atherosclerosis and cardiovascular disease of klotho , an aging process-related gene , has been highlighted.
The role microRNAs play in the transduction of neuronal activity into growth and synapse formation is largely unknown.
The role of accelerated aging as a paradigm is useful to understand long-term outcome risks for patients.
The role of allografting in adult ALL is comprehensively discussed.
The role of aluminum ( Al ) in Alzheimer disease is highly controversial.
The role of androgens has recently investigated and these hormones were considered to have a protective function on the ocular surface.
The role of androgens in the development of frailty and their utility in treating this condition are evaluated.
The role of anesthesiologists as perioperative physicians is important for optimizing surgical outcomes for elderly patients undergoing ambulatory surgery.
The role of anesthesiologists as perioperative physicians is of critical importance for optimizing surgical outcomes for elderly patients undergoing ambulatory surgery.
The role of antibiotics and surgery is discussed and compared with guideline recommendations.
The role of antidiabetic treatments on severe hypoglycemia is unknown in dementia.
The role of anxiety in pain is less well understood than the role of depression.
The role of apolipoprotein E ( ApoE ) in FTD is uncertain , though an established risk factor in Alzheimer's disease.
The role of atopy as regards diagnosis , therapy and prognosis of asthma in the elderly is addressed.
The role of autophagy in retinal ganglion cell ( RGC ) death is still controversial.
The role of behavioural factors was very low.
The role of bone antiresorption therapy such as bisphosphonates and denosumab in vascular calcification in high-bone-turnover disease remains unclear.
The role of cerebrovascular disease ( CVD ) in the interplay between late-life BMI and ADNP is unclear.
The role of certain risk factors of dementia may change during life , and the importance of having a life-course perspective has been acknowledged.
The role of chewing in nutrition is important.
The role of circadian interventions , and whether melatonin levels are a modifiable risk factor for poor sleep in older men , warrants further study.
The role of classical lipids in aging diseases and human longevity has been widely acknowledged.
The role of climate in driving selection of mtDNA as Homo sapiens migrated out of Africa into Eurasia remains controversial.
The role of close relationships and frequent contact in later life may be particularly important.
The role of CMR in patients presenting with STEMI with multi-vessel disease on CA deserves further investigation.
The role of cognition in postural control is tested with dual-task experiments.
The role of concomitant intraoperative ablation during pulmonary valve replacement surgery remains to be defined.
The role of crystallin-derived peptides in age-related lens protein aggregation and insolubilization is not understood.
The role of dehydroepiandrosterone ( DHEA ) and its sulphated form ( DHEAS ) as anabolic hormones is still debated in the literature.
The role of depressive symptoms in these associations is also investigated.
The role of dietary energy density ( ED ) in the regulation of energy intake ( EI ) is controversial.
The role of diet in aging skin is highly controversial with limited available scientific data.
The role of diet in extending lifespan and healthspan has been the subject of much research and debate.
The role of diet in prevention of various disorders is a well-established factor , which has an even more important role in the geriatric population.
The role of DNA damage in the pathogenesis of atherosclerosis has been extensively investigated in recent decades.
The role of EGF and TGF-β1 in thyroid cancer is still not clearly defined.
The role of epigenetic change in OGG1 gene in the susceptibility to oxidative stress induced cortical ARC is warranted to further study.
The role of epithelial-mesenchymal transition ( EMT ) in single-cell metastasis has been well-documented.
The role of exercise interventions on old adults ' gait mechanics that underlie training-induced improvements in gait velocity is unclear.
The role of female sex steroids as well as the ability of skeletal muscle tissue to locally produce sex steroids has been less extensively studied.
The role of FGF21 as a biomarker or therapeutic target of atherosclerotic diseases warrants further investigation.
The role of food groups and dietary nutrients on bone health in this sample of elderly Chinese women seems to be minimal.
The role of free radical damage in aging has been identified and tocopherols were shown to be involved in age related disorders.
The role of fusion , in the absence of a degenerative deformity , is uncertain.
The role of gender in this relationship is not fully understood.
The role of genetic factors in structural asymmetry has been incompletely studied.
The role of genetic variants for the other diseases are less clear.
The role of GRN expression and epigenetic mechanisms associating TMEM106B in the accumulation of TDP-43 in older persons require further study.
The role of hearing threshold differences between groups and the reduced overall stimulus level on the S-ABR were also examined.
The role of HMB in sarcopenic obesity management is still under debate and a general lack of intervention studies in this population must be recognized.
The role of holoTC in AD should be further investigated.
The role of H. pylori and its eradication remain controversial.
The role of indicators of reserve are discussed , such as educational level , work complexity and cognitive activity in these processes.
The role of inflammation in cognitive decline has generated considerable interest , although few longitudinal evaluations have been conducted.
The role of Ing2 in germ cell maturation may extend to human ING2 as well.
The role of klotho in the pathophysiology of AN and as a novel marker of disease severity should be further explored.
The role of L-ferritin genetic variations in the pathogenesis of age-related cataract is yet to be explored.
The role of MDx accumulation is discussed from an osteodynamic perspective.
The role of meaning attributed to the situation or the linguistic interpretation of the rules have nevertheless been stressed by pragmatic studies.
The role of medical rehabilitation methods in connection of neuroimmunoendocrinic homeosthasis are described in this article.
The role of melatonin in increasing neurogenesis and protecting against neurodegeneration has been investigated.
The role of melatonin in the gastrointestinal ( GI ) tract had previously been limited to its well-described anti-oxidant properties.
The role of membrane rafts in T cell signaling and T cell aging will be described.
The role of MOAG-4 in driving aggregation extends to amyloid-beta and alpha-synuclein and is evolutionarily conserved in its human orthologs SERF1A and SERF2.
The role of nuclear Ago2 has not been previously reported.
The role of nuclear CDK5 in gastric cancer tumorigenic proliferation and ex vivo xenografts was explored.
The role of nutritional intervention in this vulnerable population remains an important area of future research.
The role of oxidative stress as a remarkable upstream part is frequently reported in the signaling cascade of inflammation as well as chemo attractant production.
The role of PAI-1 in COPD with respect to metabolic and cardiovascular functions is unclear.
The role of pathogenic bacteria in progression of stable COPD and the use of prophylactic antibacterials in stable COPD are under investigation.
The role of physical activity amongst older people in inpatient rehabilitation settings has been little studied.
The role of physical and psychological working conditions was also assessed.
The role of Purkinje cell loss in the pathogenesis of this disorder merits additional study.
The role of recollection and familiarity in MCI remains unresolved and further work will be required to disentangle the mixed literature.
The role of RGN suppressing cell proliferation is associated with the regulation of expression of oncogenes and tumor suppressor genes.
The role of risk factor control requires verification.
The role of RPL24 in human malignancies is unknown.
The role of selenium in human brain physiology , as well as in aging and neurodegenerative processes , remains unclear.
The role of serious mental illness and dementia in risk for ACS hospitalization also deserves further attention.
The role of sirtuin @number@ ( SIRT6 ) in atherosclerotic progression of diabetic patients is unknown.
The role of stimulants for treating severe depression remains controversial , especially when it comes to bipolar depression.
The role of T-cell exhaustion in chronic HCV disease remains poorly understood.
The role of T cells in innate immunity is not well defined.
The role of telomeres and telomerase as a target for cancer therapeutics is an area of continuing interest.
The role of the caregiver in tracking and reporting of symptoms and the effects of individual therapeutic interventions is pivotal in this process.
The role of the CLSTN2 ( rs6439886 ) and KIBRA ( rs17070145 ) SNPs in cognitive impairment was analysed in a 75-76 years old group.
The role of the estrogen receptor @number@ ( ESR1 ) gene hypermethylation is reportedly important in the development of breast cancer.
The role of the hippocampus in memory is dependent on its interaction with distributed brain areas.
The role of the innate immunity during human ageing is not well understood.
The role of the insula in these processes may be fundamentally related to prospective thinking , a trait that increases with age.
The role of the peptide in middle-aged obesity cannot be confirmed.
The role of the pharmacist as an integral element of health care has been recognized by various international and European organizations.
The role of these magazines in building health literacy among their readers is also discussed.
The role of the somatotropic hormone axis in mammalian longevity has been studied in diverse experimental models in vivo.
The role of this cluster in MSC functionality is worth future studies since it links expansion , aging and immune system together.
The role of this field-effect lesion pathogenesis and cognitive impairment are areas to be defined.
The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized , such as prostate cancer ( PCa ) .
The role of traditional Chinese culture of Confucianism was significant in shaping perceptions and conceptions of mental illness.
The role of treatment with direct oral anticoagulant agents is unclear.
The role of TREM2 in younger , asymptomatic individuals is unknown.
The role of UVB in skin photo damages has been widely reported.
The role of vitamin D deficiency , the most common cause of elevated PTH in the elderly , needs to be further investigated.
The role of Wnt / beta-catenin signaling and beta-catenin itself in the processes of cardiogenesis and adult myocardium functioning is not fully elucidated to date.
The roles and mechanisms of Gnaq in antioxidation in the brain have not been fully explored.
The roles of BCAA catabolism in human breast cancer remains unknown.
The roles of DNA helicases / translocases are orchestrated with RPA in pathways of nucleic acid metabolism.
The roles of hydrogen peroxide and superoxide in autophagy are analysed based on the recent experimental work.
The roles of hypertension , diabetes mellitus , and hyperlipidemia are greatest in stroke patients in their 50s to 60s.
The roles of sirtuin family members are widely studied in carcinogenesis.
The roles of sirtuins in cancer are still ambiguous , although they have been extensively studied.
The roles of such variants in life span regulation remain unclear.
The role that older adults ' memory beliefs have in the meta-cognitive strategies they employ is discussed.
The Romberg and Tandem stances were used under ' eyes open ' and ' eyes closed ' conditions.
The ROR for anticoagulant-associated nervous system hemorrhage was not significantly affected by aging , as compared to GI hemorrhage.
The RORs of dabigatran increased with increasing age , although aging had little effect on warfarin-associated GI hemorrhage.
The ROSa demonstrated a better ability to discriminate elderly adults with difficulty from healthy individuals.
The ROS and RNS collectively contributes to the dysfunction of the blood-brain barrier ( BBB ) and damage to the brain parenchymal cells.
The rosiglitazone-mediated increase in SIRT1 stability is accompanied by upregulation of mitogen-activated protein kinase phosphatase ( MKP ) -7 , a JNK-specific phosphatase.
The ROTEM® analysis indicates an increased coagulability in patients with coronary artery disease and healthy elderly compared to healthy young volunteers.
The roughness analysis ( Rz ) demonstrated a significant decrease in periorbital wrinkles ( p < @number@ ) .
The route served more than @number@ meals in @number@ ( the year the programme began ) and continues to serve clients today.
The routes of indirect transmission often remain untraced , making it difficult to develop control strategies.
The routine therapy is open or laparoscopic cholecystectomy.
The Routledge handbook of cultural gerontology.
The RPE monolayer undergoes considerable lifelong re-modeling.
The RPE was recorded immediately after the sets.
The RRs were closely related to BMI changes.
The RRT was activated @number@ times ( @number@ calls per @number@ patient days ) .
The rs10981985 A allele frequency was lower in patients with cortical ARC than in control subjects ( OR @number@ @percent@ CI @number@ @number@ ) .
The rs10981985 polymorphism was significantly associated with cortical ARC in a dominant genetic model ( OR @number@ @percent@ CI @number@ @number@ ) .
The rs2229901 variant was predicted to be structure-disruptive.
The rs2970848 GG allele was associated with risk of late onset PD ( p = 0.027 ) .
The rs6311 HTR2A polymorphism was analysed with genotyping.
The rs698 ADH1C and rs671 ALDH2 polymorphisms were not associated with TL.
The rs73069071 risk genotype was also associated with altered expression of a nearby astrocyte-expressed gene , SLCO1C1.
The rs9349379 [ G ] allele was previously shown to be associated with lower risk of migraine and increased risk of myocardial infarction.
The RSA regression model showed that by the year @number@ PHF treated with RSA will increase @percent@ from @number@
The RSFA is therefore a candidate for use in adjusting for age-related changes in vascular reactivity in fMRI studies.
The RT3DE feasibility for LAV measurement was @percent@.
The RT data were consistent with previously known effects of age and gender on RT.
The RT-PCR showed that rutin could decrease BCL2 expression and BCL2 / BAX ratio.
The RT program comprised eight exercises in which the participants performed one set of 10-15 repetitions maximum for a period of @number@ weeks.
The RTs for the secondary cognitive tasks increased significantly while using the VTF in both younger and older adults.
The RTT group was slower to engage , more distractible , and slower to reengage.
The RT was inversely and significantly related to MPOD at @number@.0° and at @number@.0° from the foveal center , but not to central MPOD.
The run time for the method was @number@ min per sample.
The Runx family genes play important roles in development and cancer , largely via their regulation of tissue stem cell behavior.
The rural elderly population was more disabled and had more diseases than the urban elderly population , despite being slightly younger than the urban cohort.
The rural population had a higher prevalence of overall MCI ( @percent@ vs @percent@ , P < @number@ ) .
The rush of leukocytes attracted by chemokines and cytokines may induce fibre injury and HLA-I overexpression.
The RV-GDT has increased power by efficiently incorporating information beyond first-degree relatives and allows for the inclusion of covariates.
The saddle shape of the mitral annulus was preserved across age and size.
The safety and efficacy of numerous antihypertensive combinations in elderly patients have been demonstrated in a number of clinical trials.
The safety and patient satisfaction data from these publications are discussed in this review.
The safety and tolerability of oxycodone DETERx were also evaluated.
The safety and tolerability profiles showed no new or unexpected safety concerns.
The safety aspects of Cerebrolysin were comparable to placebo.
The safety data from a selection of these studies was examined.
The safety of each dose was confirmed prior to administering the next dose.
The safety of nanodelivery systems for use in food applications is largely unknown.
The safety of the biotherapies therefore still needs to be confirmed , together with the benefit-risk balance of corticosteroid therapy compared with biological therapy.
The safety of using the TriFractional system was established by the physicians ' assessments and observations of adverse events after each treatment.
The safety profile and efficacy of all three injectables has been intensively evaluated in innumerous clinical studies.
The safety profile of HMB is unequivocal.
The safety profile of menatetrenone was similar to alfacalcidol.
The safety profiles of LGP-HA and LGP-HA + L were similar to each other in all skin types.
The safety profile was similar to previously reported trials with BoNTA.
The ( SAGA ) chromatin-modifying complex possesses acetyltransferase and deubiquitinase activities.
The sagging of the upper lips led to the appearance of an increased mouth width.
The sagittal alignment changed to lordosis at the level of L2.
The SAI is related to SA above the effect of age with differences existing across age groups and sex.
The SAI , motor thresholds and intracortical inhibition and facilitation were not age-related.
The salience and the relevance of elements present in the parking environment were manipulated during parking manoeuvres.
The salience of these topics is closely related to major sociodemographic and political driving forces , i.e. aging and social insurance reforms.
The saliva flow , pH , Quality of Life ( QoL ) , and caries status were recorded.
The salivary and plasma lipofuscin levels were positively correlated , and the age is positively correlated with lipofuscin content in saliva.
The salivary flow rate was evaluated at baseline and follow-up by collecting stimulated saliva.
The Salud y Bienestar program conducted by community health workers was effective approach to improving diabetes knowledge in the Hispanic population.
The salutogenic theory , based on resources and comprehensibility , manageability , and meaningfulness , can be integrated into a learning model.
The salvation of advanced schistosomiasis patients in non-endemic areas should be strengthened.
The same 3-way interaction was observed when high food insecurity was predicted ( P = @number@ ) .
The same analyses gave non-significant results in females.
The same analyses were performed on RBCs that had been separated according to density using discontinuous Percoll gradients.
The same anesthesiologist assessed @percent@ of cases.
The same approach is followed to present the sensory implications of phenolic and phenolic-derived compounds in wine.
The same association between worsening glycemic status and bone strength was not observed in men.
The same association was found in participants with no SCD and had regular activities for over @number@ years ( n = @number@ ) .
The same classifier resulted in AUC = @number@ and @number@ for sd-aMCI / NC and sd-aMCI / md-aMCI classification experiments respectively.
The same cognitive difference is also observed in humans.
The same differences remained when corrected for mass.
The same direction of effect and p < @number@ indicated replication.
The same etch-and-rinse adhesive system and composite resin were used for all groups ( n = 30 beams ) .
The same gene-dosage effect was seen on memory and motor deficits.
The same genotype of mouse has a very different phenotype and response to physiological or pharmacological intervention when raised below or at thermoneutrality.
The same geometric features were measured in @number@ patients ( @number@ ± @number@ years old ) with unilateral ACD.
The same information was obtained for @number@ spouses of TB-patients , and @number@ controls.
The same is true for BMI and waist girth , commonly used anthropometric indicators of adiposity.
The same light that allows vision to occur is nevertheless also potentially toxic to retinal cells in certain situations.
The same measures were related to language function as a reference cognitive domain.
The same might also be the case for other local and , in particular , other widespread , musculoskeletal pain.
The same monotonic relationship held with adjustments for age , race , sex , cardiovascular risk factors , and health behaviors.
The same mutation has been described in a patient with bipolar disorder , but up to now , not in patients suffering from schizophrenia.
The same occurs in stage II , even though to a lesser extent.
The same participants then carried out @number@ more difficult out-of-scanner tasks , which provided in-depth measures of changes in performance.
The same patterns were observed in data from @number@ to @number@ and from @number@ to @number@
The same pattern was observed in younger adults , but the effects were not as strong.
The same pattern was seen in both the age groups.
The same population of Basse-Normandie will get old in the @number@ years to come.
The same principles of treatment should apply in the elderly.
The same process was realized on the remaining disks after @number@ days.
The same recordings were performed in @number@ control subjects , paired for gestational and postnatal age.
The same regions were related to subsequent memory of intentionally encoded associations and were thus task relevant.
The same relation was found when using area under the curve.
The same results were evident in secondary analysis in which we matched depressed and non-depressed participants for age and sex.
The same results were found for CC ( p < 0.001 ) and MAMC ( p < 0.001 ) .
The same subset of chondrocytes responsible for growth plate mineralization is also present in thyroid cartilage mineralization.
The same tendency was observed for the level of hOGG1-sensitive sites , whereas there was no association with the level of strand breaks.
The same test procedures using pure-tone audiometry and a short questionnaire were applied to the three cohorts of 75-year old residents in the same city.
The same therapeutic modalities can be used to treat erectile dysfunction after radical prostatectomy.
The same three lines can be marked in the contralateral side or can differ in cases of asymmetry.
The same trend was observed in both the prevalent and incident patient cohorts.
The same tumour marker assay should be used to monitor a given patient.
The same type of mutations has recently been shown to cause frontotemporal dementia ( FTD ) without the presence of any bone phenotype.
The same was done for BCVA and the functions were compared.
The same was not true for PS.
The same was shown for a peptide corresponding to a highly conserved domain of all retroviral TM proteins , the immunosuppressive domain.
The sample collection period lasted @number@ days.
The sample comprised 50- to 65-year-old women whose menstruation had ceased at least @number@ year before and who had not undergone hormone replacement.
The sample comprised beneficiaries aged @number@ years and older ( N = @number@ person-years of observation ) .
The sample comprised @number@ adults with Down syndrome who were free of dementia.
The sample comprised @number@ older adult Brazilian women , @number@ ( @percent@ ) of whom had performed lifelong jobs.
The sample comprised @number@ older adults who were interviewed in @number@ and re-interviewed in the following waves.
The sample comprised @number@ participants aged ≥52 years.
The sample comprised @number@ people aged @number@ years or above.
The sample comprised @number@ ( @percent@ African American ) adults aged @number@ and older who participated in memory , reasoning , or speed training.
The sample comprised @number@ Portuguese undergraduate students enrolled in degrees in nursing , social work , and psychology.
The sample comprised ten interview participants and fifty-seven Internet survey respondents , aged between @number@ and @number@ years.
The sample consisted of community-based older adults , @number@ with , and @number@ without , memory concerns.
The sample consisted of N = @number@ drivers aged ≥70 years and study participation lasted @number@ or @number@ years for most participants.
The sample consisted of @number@ dyads , caregiver-patient.
The sample consisted of @number@ elderly individuals evaluated from January to @date@ .
The sample consisted of @number@ elderly , @number@ caregivers and @number@ speech-language therapists.
The sample consisted of @number@ females and @number@ males aged 20-60 years randomly recruited from Shanxi Province of PR China.
The sample consisted of @number@ healthy controls.
The sample consisted of @number@ layoff survivors and @number@ non-survivors ( employees whose organizations had not downsized ) .
The sample consisted of @number@ men and @number@ women aged ≥60 years who were married and had at least @number@ child.
The sample consisted of @number@ MOW clients.
The sample consisted of @number@ participants aged 60-93 years.
The sample consisted of @number@ participants ( @number@ women and @number@ men ) from @number@ to @number@ years of age.
The sample consisted of @number@ patients , aged @number@ years or more , randomly selected in three hospitals in Rio de Janeiro , Brazil.
The sample consisted of @number@ residents of the OPH , aged 65-96 years , and @number@ caregivers from randomly selected twenty-seven OPH.
The sample consisted of @number@ respondents , aged 18-84 years , who were responsible for food purchasing and cooking in the household.
The sample consisted of @number@ staff delivering direct care and working in out-of-home community placements for persons with ID in New York state.
The sample consisted of @number@ twin pairs with a median age of @number@ years.
The sample covers the period from @number@ to @number@
The sample for this analysis included @number@ women and men aged @number@ years and older.
The sample from the shared-housing arrangements comprised all residents that lived in SHAs.
The sample included a retrospective cohort of nursing home residents in the Vancouver Coastal Health region ( n = @number@ ) .
The sample included a total of @number@ probands recruited from a clinically enriched community screening and their @number@ adult living and deceased first-degree relatives.
The sample included data on @number@ dementia caregivers with pre- and six-month post-placement data and @number@ with pre-placement , six-month , and 12-month post-placement data.
The sample included @number@ African Americans with a mean age of @number@ ( SD = @number@ ) .
The sample included @number@ community-dwelling older people aged 60 + living in the Netherlands.
The sample included @number@ Dutch respondents aged @number@ to @number@ at baseline in @number@ and six follow-ups covering a time span of twenty years.
The sample included @number@ male and female community-dwelling adults @number@ years and older.
The sample included @number@ older ( 64-95 years old ) white and African American women from the Women's Health Initiative.
The sample included @number@ older adult patients with schizophrenia and @number@ older adult healthy controls that were administered the battery at two time points.
The sample included @number@ patients without dementia who could be identified as having demonstrated either valid or invalid responding , based on standardized criteria.
The sample included @number@ persons over @number@ years of age.
The sample in this study was @number@ residents who were older than @number@ years and who resided in Gangwon Province , South Korea.
The sample is @number@ adult children from Norway , Spain , and Israel , countries selected because they represent different family cultures and welfare regimes.
The sample ( n = 31 ) , was divided into two groups.
The sample ( n = 342 ) was administered three VMMSEs within @number@ weeks after F2F testing.
The sample ( n = @number@ ) consisted of @number@ women and @number@ men age 18-60 years.
The sample ( N = @number@ ) was assembled based on an expansive search of the peer-reviewed literature using multiple electronic databases.
The sample ( N = @number@ ) was randomly split into two halves : one half for model development and one half for model confirmation.
The sample of this study was comprised of @number@ volunteers over @number@ years of age , which were grouped into six different age groups.
The sample population included adult patients undergoing nonambulatory nonobstetric surgery in a single institution over a 1-year period.
The sample size and procedure-therapeutic issues play , at most , a minor role in this clustering.
The sample size is @number@ with @percent@ with mobility impairment.
The sample size prevented additional subgroup analyses , including potential effects of medication , smoking status , and lifestyle.
The sample size will consist of @number@ participants.
The samples were assigned to two groups as follows : lesion and remote cartilage were adjacent to and remote from the osteoarthritic cartilage , respectively.
The samples were characterized by scanning electron microscopy coupled with energy dispersive x-ray spectroscopy.
The samples were divided into @number@ groups containing @number@ @number@ @number@ and @number@ wt% ZnO additive , respectively.
The samples were further dissected , fixed , and stained for histological examination according to HDS.
The samples were hydrolyzed and after derivatization , the extent of aspartic acid racemization was determined by gas chromatography.
The samples were nationally representative of the Swedish population aged 77 + ( total n = @number@ ) .
The samples were stored for @number@ h in distilled water or @number@ months under simulated pulpal pressure.
The samples were subjected to alternate aging in phosphate buffered saline and cyclic loading.
The samples were submitted to immunohistochemistry and Western blotting analyses.
The samples were used to determine salivary levels of free testosterone and cortisol.
The sample type comparison study was performed at @number@ different hospitals.
The sample used a median of ten medicines per patient.
The sample was characterized in a battery of neuropsychological tests and in terms of brain structural asymmetries using a ROI-based approach.
The sample was collected by geographically based proportional stratified sampling.
The sample was composed by @number@ older adults from Sao Paulo , SP , Southeastern Brazil.
The sample was composed of @number@ depressed older adults ( age ≥ @number@ ) who were newly recommended antidepressant treatment by their physicians.
The sample was composed of @number@ healthy and nonsmoking males , aged from @number@ to @number@ years.
The sample was composed of @number@ participants ( @number@ men and @number@ women ) from @number@ to @number@ years old.
The sample was comprised mainly of women ( n = @number@ ) and the average age was @number@ years.
The sample was dichotomized according to education level into low ( ≤8 years ) and high ( > 8 years ) education groups.
The sample was dichotomized on disability.
The sample was divided into five age groups and partial strong MI was established using multigroup confirmatory factor analysis.
The sample was divided into three risk strata based on approximate risk score quartiles , with the middle two quartiles combined.
The sample was drawn from a representative longitudinal cohort of older persons in Israel.
The sample was largely a dentate one ( @percent@ ) ; with a mean DMFT score of @number@ ( s.d.
The sample was largely female , White widows / widowers , with a mean age of @number@ ( SD @number@ ) years.
The sample was made up of healthy older adults living in the Marche Region aged @number@ and over.
The sample was @number@ Latinas who self-selected into this program.
The sample was @percent@ female and , on average , @number@ years of age at baseline.
The sample was @percent@ female and @percent@ African American.
The sample was predominately female ( @percent@ ) , and @percent@ of participants were aged > 85 years.
The sample was random , with a predominance of females , in which the older participants had greater functional impairment.
The sample was selected on the basis of multi-stage clustered design from the non-institutionalized adult population.
The sample was then divided into two subsamples with a cut-off age of @number@ years.
The sampling techniques of ADAMS and EBSHP were rather similar , whereas their disease definitions were not.
The SAM was developed as a mouse showing a senescence-related phenotype such as a short lifespan or rapid advancement of senescence.
The SAPS II , APACHE II score , and SOFA score were calculated based on the worst laboratory values in the ED.
The Sarcopenia and Physical Frailty in Older People : Multicomponent Intervention Strategies ( SPRINTT ) is the obvious result of these strategies.
The sarcopenic obese group had more participants ( @percent@ men , @percent@ women ) with a high risk of CVD ( ≥20% ) .
The SAS program was used to perform the statistical analysis of independent samples and parametric data.
The satellite cell is the physiologically quiescent muscle stem cell that resides beneath the basal lamina and adjacent to the sarcolemma.
The Satisfaction with Food-related Life ( SWFL ) scale measures a person's overall assessment regarding their food and eating habits.
The saturated and trans fat content , post-2009 , was modest for French fries.
The SBR in females was higher than in males.
The SBS appears to meet the criteria required to make it a useful tool.
The SBS is the first attempt to assess lower balance abilities.
The scale can be used in cross-cultural research to test hypotheses that predict associations among filial values , filial caregiving , and caregiver health outcomes.
The scale comprised three factors : dependability , communication skills and service usefulness.
The scale demonstrated moderate reliability with KR-20 alpha of @number@ for Whites , @number@ for African Americans , and @number@ for Hispanics.
The Scale for Children's Attitudes Towards Aging was used.
The scale had a Cronbach's alpha of.90.
The scale had significantly positive correlation with the Korean Perceived Stress Scale ( KPSS ) .
The scale is potentially useful for promoting health policies , practices , and interventions within communities.
The scale nonetheless continues to challenge postmodern associations of identity and sexuality.
The scale's reliability ( internal consistency ) was analysed using Cronbach's alpha and inter-item correlations.
The scale's utility in direct clinical care merits further examination.
The scale-up of antiretroviral therapy ( ART ) has led to a substantial change in the clinical population of HIV-positive patients receiving care.
The scale was based on items derived from a literature review and focus group interviews.
The scale was dichotomized to achieve a better reliability score and item fit.
The scale was translated using the back-translation technique.
The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing.
The scanning electron microscope showed acceptable film appearance and differential scanning calorimetry analysis confirmed complex formation.
The SCC-∆WMH was more than five times larger in the CR-decline group compared to the no-decline group ( p = @number@ ) .
The SC divides to add nuclei for growth and repair , and the SC identification and number are discussed.
The scenario exposure comprises two hypothetical case vignettes describing situations demanding decisions for LST.
The scenario exposure improved the knowledge level of participants ( paired samples t-test , p < @number@ ) .
The scenario is complicated even further by the presence of both age-dependent and age-independent competing causes of death.
The scenario of 18-month treatment duration was the only scenario not indicating cost-savings with an ICER of €425 / QALY.
The Schirmer test results were also improved and statistically significant ( P < @number@ ) .
The school-age children reported no increased depression scores.
The SC hydration , L ( ) value , elasticity and thickness increased , whereas the TEWL and MI value decreased.
The science and study of the biological basis of aging , biogerontology , is now a well-established field with solid scientific base.
The scientific evidence base from which to develop specific treatment recommendations for constipation in older people is , for the most part , slim.
The scientific literature indicates that metopic suture consolidates with closure in the early stages of life.
The SciFinder and the World Intellectual Property Organisation databases have been used as main sources for the search.
The SCIT had excellent internal consistency , as demonstrated by a high split-half reliability measure ( @number@.88-0.93 ) .
The sclera becomes rigid and may become calcified.
The sclera shares many compositional characteristics with Bruch's membrane , but it is much easier to access for in vivo Raman analysis.
The scope of such programs is quite vast.
The scope of this paper is to make projections of the number of elderly individuals with dementia.
The scores are typically formed by adding up numerical responses to a number of questions.
The scores for each measure were standardized to t-scores that controlled for age , sex and education.
The score significantly decreased from baseline to follow-up ( F = @number@ p < @number@ ) .
The scores obtained in these scales were correlated to the mean times of trials execution.
The scores of the PHQ-2 discriminated between subjects with and without depression , with an area under the receiver operating characteristic curve of @number@
The scores were able to discriminate between normal controls and clinical patients.
The scores were correlated with two disease markers , disease burden and striatal volumes , in the premanifest HD subjects.
The scores were evaluated for interobserver reliability using intraclass correlation coefficients.
The score was applied to the second half of the sample ( test cohort ) .
The score was not helpful in guiding the site of care at admission in older patients with pneumonia.
The score with the best equilibrium between sensibility and specificity was @number@ ( sensibility @percent@ and specificity @percent@ ) .
The scoring mechanism was applied to three external data sets and fit to the Rasch model was assessed.
The Scottish Mental Surveys of @number@ and @number@ tested the intelligence of almost all school children at age @number@
The scrapie isoform ( PrP As the immune-competent cells of the brain , microglia play an increasingly important role in maintaining normal brain function.
The screening followed a tiered three-step approach , with increasing specificity.
The screenings did not identify disease causing variations in either of the genes among the PD patients screened.
The screening test we developed could help identify functionally independent older adults with sarcopenia who are good candidates for intervention.
The screening was performed by @number@ neuropsychiatrists , using a modified form of the Mini-Mental State Examination.
The SC treatment resulted in decreased WBSF and increased myofibril fragmentation index compared with control.
The SDC and SAT elicited greater activity in the left middle frontal region of interest.
The SDG group showed higher levels of growth hormone ( GH ) , free fatty acids and ammonia compared with DG.
The SDPP was a @number@ month translational study aiming to promote increased physical activity and dietary changes.
The SDQ is a reasonably accurate , rapid approach for ranking usual frequencies of selected nutrients and foods.
These 10-year decreases in CRP were not observed in those not reporting statin use.
These aberrations are not uncommon in oocytes obtained after ovarian hyperstimulation for in vitro fertilization.
These abilities should be the target of cognitive training.
These abnormal behaviors could be caused by alteration of hippocampal circuitry as a consequence of the lack of BRINP1.
These abnormalities caused dilatation of infundibula , hair loss , and cyst development upon aging.
These abnormalities in B lymphopoiesis likely contribute to the poor humoral immunity seen in old age.
These abnormalities might represent either a clinically silent CP or a toxic effect of smoking and alcohol.
These abnormal phenotypes are very similar to that of Gaucher's disease in human.
These \ "accessory \ " cell populations are proposed to influence myogenesis via direct cell contact and secretion of paracrine trophic factors.
These achievements make it possible to use well proven in different fields of science and engineering data mining methods for tasks in gerontology and geriatrics.
These acquisitions may offer real potential for exploiting and analyzing volumetric measurements of teeth.
These actions by the OG were associated with less ankle plantar-flexion , more hip flexion and anterior pelvic tilt ( p < 0.05 ) .
These actions of Pb were specific and were not observed when substituted by another metal.
These activators can be induced by hematopoietic stimulators such as cytokines.
These activities may be localized and systematic.
These activities seem to persist during senescence of the target cells.
These activities will promote interprofessional health care education and practice.
These acutely ill patients are challenging to frontline nurses because they frequently have multiple chronic conditions.
These adaptations correspond to an enhanced aging pattern in RA patients.
These adaptations could offer a new aspect for the explanation of the generally observed physiological and molecular alterations found in DCM.
These additional cases had a subtly different neurocognitive profile to MCI cases , including poorer social cognition.
These adiposity traits are intercorrelated but their underlying structure has not been extensively investigated.
These adjusted surgery rates partially explains the sharper decrease in crude surgery rates in the HA group than the HI group.
These adults showed substantial improvements over the training period in game performance.
These advances are important for both , the basic knowledge of stem cell regulation , and their practical translational applications into clinical medicine.
These advances generally require the use of novel natural or synthetic chemical agents with the potential to affect human health.
These advances hold promise for increasing vehicle safety , reducing injuries , and making the driving task more comfortable.
These advances in fundamental understanding both allow better clarification of the potential cross-system dysregulation that occurs in ageing and open new avenues for intervention.
These advances may improve the understanding and classification of peripheral neuropathies.
These advances will be reviewed in the context of initial or early AHF management.
These advantages allow reducing the number of animals for Alzheimer's disease research.
These advantages make HA fillers the most common of the temporary fillers on the market.
These adverse effects are particularly important for the use of clozapine in older people , who are generally more susceptible to medication-related adverse effects.
These adverse effects of pharmacotherapy may be highly detrimental , as well as highly expensive.
These AEDs target mechanisms of epileptogenesis involving amyloid β and tau.
These affect the recognition of the first symptoms of dementia by the patient's caregiver.
These aftereffects were reduced but remained clear even when facial gender changed between adaptor and test faces.
These age and lifestyle-related metabolic diseases are often accompanied by insulin and leptin resistance , as well as aberrant amylin production and signaling.
These age-dependent differences were driven by proportional increases in NPR in membrane-associated cortical fractions.
These age differences in the valence of memory were consistent across culture.
These age-differential findings were corroborated with nested-model comparisons.
These age-elevated IL-17 responses induce a lethal immune pathology during viral infection.
These age-induced differences need to be considered when developing vaccination strategies for different age groups.
These ageing phenomena can usually be treated more effectively with several extraoral treatment modalities that also enhance perioral aesthetics.
These agents all feature more predictable pharmacodynamic and pharmacokinetic properties than warfarin.
These agents are safer and more efficacious than classic cytotoxic drugs making them a very attractive therapeutic option , especially in older adults.
These agents decreased senescence-associated hypertrophy with IC50s : @number@ @number@ @number@ @number@ and @number@ nM , respectively.
These agents have led to significant improvements in progression-free survival in selected trial populations.
These agents were stopped @number@ to @number@ days before surgery.
These age ranges were generated from both approaches and are presented as reference tables useful for historic male and female Italian samples.
These age-related abnormalities are mediated in part by cysteine-rich protein @number@ ( CCN1 ) .
These age-related changes are presented here , including an examination of the impact of genetic and lifestyle factors.
These age-related changes impact older transplant candidates and may have significant implications for an age-adapted immunosuppression.
These age-related changes likely contribute , in part , to the diminished ability of EPCs to resist an apoptotic stimulus in older men.
These age-related declines are not inevitable , however : older adults with a lifetime of music training do not exhibit neural timing delays.
These age-related deficits become more apparent at higher walking speeds.
These age-related effects are the result of responses initiated by cardiovascular proinflammatory cells.
These age-related neurocognitive improvements were not found in a group of individuals with schizophrenia , who had comparable levels of social functioning.
These age-related physiologic changes influence both pharmacokinetics and pharmacodynamics of drugs in elderly patients.
These aggregates are deposited inside or outside the cell due to hereditary mutations , environmental exposures or even normal aging.
These aggregates are thought to be toxic to neurons , either by causing some neurotoxic signalling defects or by obstructing the cell function.
These aggregates of damaged proteins are detrimental to normal cell functions.
These aggregates showed typical characteristics of FUS-ALS including methylated FUS.
These aggregates typically contain aggregation-prone pathogenic proteins , such as amyloid-beta in Alzheimer's disease and alpha-synuclein in Parkinson's disease.
These aging effects were evident in middle age , even in the absence of significant hearing loss.
These aging processes affect rods and rod-bipolar cells.
These aging-related deficits affect the quality of life and present challenges to our aging society.
These aims are fortified by the ability to leverage the considerable database on health , lifestyle and socio-demographics collected prospectively from @number@ to date.
These algorithms were developed using a homogenous population of healthy older adults.
These alleles appear to be indicative of a common genetic susceptibility.
These alleles correspond to the minor alleles initially found more frequent in controls than in cases of AD.
These all negatively correlate with B cell function , measured by activation-induced cytidine deaminase , the enzyme of class switch recombination and somatic hypermutation.
These alterations are closely related to the increased mortality and morbidity rates observed in this population.
These alterations are more severe in diabetes and accompany reduced relaxant efficacy of PDE5 inhibition.
These alterations in eye tracking all reverted to normal ranges after surgical treatment of underlying pathological conditions in these @number@ neurosurgical cases.
These alterations in RyR expression at early disease stages may reflect the onset of pathologic mechanisms leading to later neurodegeneration.
These alterations likely impact the processing and trafficking of proteins , which might contribute to neuronal dysfunction in AD.
These alterations of testicular histology and gene expression patterns were specific to TAp73 null mice and not features of mice lacking p53.
These alterations potentiate the pro-coagulant status developed with aging , highlighting the endothelial role in the development of thrombosis in aging.
These alterations were highly reminiscent to the phenotype of chloracne / \ "metabolizing acquired dioxin-induced skin hamartomas \ " ( MADISH ) patients.
These alterations were of similar magnitude in younger and older adults.
These altered genes could account for the abnormal muscle contraction , decreased ATP amount in sensitive skin.
These amplitude reductions are interpreted as an indication of multisensory efficiency as fewer neural resources were recruited to achieve better performance.
These analyses examined the longitudinal impact of dosage ( number of training sessions ) on the improvement and maintenance of cognitive and everyday function.
These analyses explore the structure of depressive symptoms in older patients diagnosed with major depression by identifying clusters of patients based on their symptom profiles.
These analyses included a total of @number@ subjects ( males / females : 623 / 1065 ) , aged @number@ to @number@ years.
These analyses include @number@ subjects evaluated for incident disease from @number@ through @number@
These analyses of large-scale longitudinal national probability panel data indicate that different dimensions of personality follow distinct developmental processes throughout adulthood.
These analyses revealed consistently lower signal-to-noise ratios for anatomical as well as functional MRI data during simultaneous EEG registration.
These analyses showed clear learning difficulties in PreAD-1 subjects ( F = @number@ p = @number@ ) .
These analyses show that the association of SNPs tagging SERINC5 differs substantially across the @number@ items of the PAI-BOR.
These analyses suggest critical developments in decision processes during the adolescent years and decline in a cognitive process leading to decision-making deficits after age @number@
These analyses were performed per cohort and in a meta-analysis of pooled data.
These analyses were performed separately for estrogen receptor ( ER ) -positive and ER-negative breast cancers.
These anatomical correlates may be linked to previously known effects of TV viewing on verbal competence , aggression , and physical activity.
These and future well-designed trials can better inform the field regarding the utility of exercise in the treatment of depression.
These and other informations suggest that a better understanding of RACK1 transcriptional regulation is essential to unravel its role.
These and other phenomena of synaptic plasticity are probably crucial for the involvement of telencephalic neurocircuitry in spatial learning and memory.
These and other risk factors , as well as diagnostic strategies , are covered in the first section of this review.
These and other still unanswered questions remain critical to understanding the impact of multifaceted epigenetic machinery on the age-related dysfunction of CNS.
These and studies in animal models have suggested that the early environment , especially early nutrition , plays an important role in mediating these associations.
These angiogenic effects of TRF2 are uncoupled from its function in telomere capping.
These animal models are potentially useful for neuroscience research now and in the near future.
These animals display a significantly earlier disease onset and reduced overall survival , compared to controls.
These animals should possess protective molecular adaptations relevant to age-related diseases , particularly cancer.
These anomalies were most likely the consequence of notochordal remnants presence within the intervertebral discs and in the vertebral bodies.
These anterior ocular biometric parameters were correlated with increasing age ( p < 0.01 ) .
These anterior realignments have to be supplemented with posterior fixation and or osteotomies.
These antiarrhythmic effects of vernakalant were durable , with most responders remaining in sinus rhythm @number@ hours after treatment initiation.
These antibodies are freely available to other researchers.
These antihypertensive agents have complementary vascular effects that enhance cardiovascular protection and reduce side-effects.
These antioxidants have low skin bioavailability , owing to their poor solubility , inefficient skin permeability , or instability during storage.
These anxieties can amplify negative perceptions of the aging process when the offspring enter old age.
These AoA estimates can be downloaded from the Psychonomic Society's Web archive of norms , stimuli , and data at www.psychonomic.org / archive.
The SEAP method offers a new approach for measuring the dynamic encoding of acoustic features at multiple levels of the auditory pathway.
These approaches are intended for intensively assessed epidemiological cohorts where goal is valid and reliable case detection with efficient and cost-effective tools.
These approaches have been used in GlaxoSmithKline from drug discovery to registration and have been applied to @number@ drugs from a number of therapeutic areas.
These approaches require nevertheless a real political and organizational willingness.
These approaches to maximizing erectile function are complementary rather than competitive , as they operate on entirely different aspects of erectile hydraulics.
The search algorithms for dementia achieved respective sensitivity and specificity of @percent@ and @percent@.
The search encompassed the MEDLINE and LILACS databases and was executed during @date@ using the keyword sarcopenia.
The search engine looked for the terms ' oxidative stress AND neurodegenerative diseases AND nutrition ' in @number@ different scientific collections.
The searches were limited to the period from @number@ to @number@
The search for eternal youth has created a market for testosterone treatment in aging men during the last few years.
The search for new treatment is made ever more urgent due to increasing population aging.
The search for the genetic determinants of extreme human longevity has been challenged by the phenotype's rarity and its nonspecific definition by investigators.
The search for the holy grail in facial rejuvenation is an ongoing quest.
The search identified @number@ relevant experimental studies.
The search identified @number@ subjects form @number@ articles.
The search included MEDLINE and EMBASE databases and years from @number@ to @number@
The search included the MEDLINE , Embase and the Cochrane Controlled Trials Register databases.
The search produced @number@ publications that met the inclusion and exclusion criteria for the patient population of @number@ years an older.
The search strategies yielded total records screened from PubMed.
The search target was defined by a conjunction of color and orientation.
The search was actualized in @date@ .
The search was augmented by reviewing the reference lists of relevant papers.
The search was conducted in the following databases : Pubmed , EMBASE , Cochrane Library , PEDro , CINAHL and LILACS.
The search was limited to articles published since @number@ to date.
The search was limited to peer-reviewed English journals.
The search was limited to studies published in English ( @date@ to @date@ ) .
The search was limited to studies published in English from @date@ to @date@ .
The search was limited to studies published in English from @date@ to @date@ .
The search was restricted for all English-language articles from @number@ to @date@ that implied technology-based interventions.
The search was restricted to English language papers.
The search was restricted to studies published from @number@ to @date@ .
The search yielded @number@ articles , of which @number@ passed the title / abstract screening process , and @number@ were included after full-text review.
These are arguably the most irreplaceable category of important biodiversity conservation sites.
These areas are part of the attentional system , which may decline with aging even in healthy elderly individuals.
These areas have shown great promise to date , but more and larger clinical studies will be required before these treatments become a clinical reality.
These areas included the paralimbic regions for typical presentations of sporadic EOAD.
These areas resorb in a specific and predictable manner with aging.
These are assessed in relation to the measurement of the patient's muscle strength , walking speed and balance.
These areas should be specifically examined in patients undergoing facial rejuvenation and addressed to obtain superior aesthetic results.
These are certainly needed - our ageing and unsteady constituents are steadily increasing.
These are commonly found in elderly people with geriatric syndromes such as delirium , gait disorders and incontinence.
These are complex issues , and it may be difficult and time-consuming to discern between normal brain functional changes and specific pathology in practice.
These are crucial factors in countries experiencing rapid population aging.
These are currently the subject of discussion in immunology , but completely unexplored in cancer biology.
These are described in relation to factors that influence the intensity and the consequences of pain experiences.
These are essential for prioritising treatment during hospitalisation and after discharge.
These are extremely neurotoxic.
These are important considerations in deciding optimal patient management.
These are issues that can be addressed ; and changes , implemented.
These are mostly related to technique and amount of fat injected.
These are not recommended for older adults due to risk of sedation , cognitive impairment , and falls.
These are offered as an insight into the different needs and attitudes that multigenerational groups bring to the nursing workforce.
These are phenotypes common to accelerated cellular ageing.
These are potentially simple and practical predictors of prognosis.
These are problems of high relevance in the aged population , especially in the development of irritant contact dermatitis.
These are questions that we have extensively explored in our efforts to establish new medical applications of neuroplasticity-based therapeutics.
These are resolved to their four constituent chromatids during two meiotic divisions.
These are the first systematic findings concerning the accuracy of children's dating of very long-term memories.
These are the women who serve multiple roles as caregivers for their children , spouses , and , increasingly , their parents.
These are thought to be neurotoxic.
These are two narrow-age cohorts at age @number@ ( n = @number@ ) and @number@ ( n = @number@ ) years.
These are used to create four equivalent 20-item tests , three of which are used in the study.
These are useful across all educational levels in deep learning and comprehension strategies assessments.
These arguments underline the need for a preventive lifelong health perspective from childhood through old age.
These arterial-cardiac interactions are also described.
These articles also discuss recent insights into the strategies cells have evolved to neutralize toxic aggregates by sequestering them in specific cellular locations.
These articles point to a common theme that the immunological milieu in old age is substantially different from that seen in the young.
The seasonal variation was ±12 nmol / L in the younger cohort and ±7 nmol / L in the older cohort.
The seasonal variation was larger than the longitudinal change.
These aspects are even more paradoxical , as the certain diagnosis is established only at necropsy , on anatomopathological lesions.
These assessments have improved understanding of the clinical manifestations noted in these patients , including disability and cognitive impairment.
These assessments were used to compare a physical activity intervention with a health education control.
These associated changes in bone microstructure , density , and biomechanics with age may lead to an increasing risk of osteoporosis and fracture.
These associations appear to be specific to non-Hispanic white participants.
These associations did , however , generally not pass correction for multiple testing.
These associations did not differ by sex.
These associations did not vary by gender or age.
These associations did not vary by marital satisfaction , but were slightly stronger for respondents reporting poor health.
These associations have been observed on measures of global cognition and across multiple domains of cognition.
These associations have not been widely replicated in further studies.
These associations partly overlap with the brain-behavior associations between M1 and manual motor performance.
These associations persisted after adjustment for comorbidities and exclusion of those with a Mini-Mental State Examination score less than @number@
These associations persisted at @number@ months for the genu ( @number@ p = .02 ) and splenium ( @number@ p = @number@ ) .
These associations persisted during the normal- but not the low-sodium condition ( both P < 0.005 ) .
These associations persisted even after excluding patients with clinically manifest cardiac disease.
These associations remained after adjustment for smoking , alcohol use , widowhood , caregiving status , cognitive function , physical disability , and medical conditions.
These associations remained significant after adjusting for leisure-time physical activity.
These associations remained significant when accounting for demographics , medical illnesses , and cognitive function.
These associations remained statistically significant even after controlling for age , gender , and presence of metastases.
These associations remained unaccounted for by the social network and economic variables.
These associations remained unchanged after censoring for incident stroke.
These associations remained when corrected for age and cardiovascular risk factors.
These associations still persisted when only AD cases without a history of cerebrovascular disease were included.
These associations suggest a possible role for sex hormones and OSA in the pathogenesis of IIH in men.
These associations suggest that Αβ deposition is not a benign process.
These associations were 10%-15% greater without controlling for leukocyte cell types.
These associations were comparable for men and women.
These associations were consistent across domains.
These associations were evident : for cardiovascular and , to a lesser extent , cancer mortality , and within-study , within-subgroup analyses.
These associations were found for even minimal levels of VI.
These associations were found independent of the magnitude of other pivotal markers of cognitive decline , i.e. cerebro-vascular damage and hippocampal volume.
These associations were independent of cardiovascular risk factors , co-morbidities , and medications.
These associations were independent of childhood cognition and education as well as a range of other potential confounders.
These associations were independent of sociodemographic and cardiovascular factors.
These associations were iron load dependent.
These associations were maintained , albeit attenuated , after adjustment.
These associations were modified by blood pressure levels but not the APOE ε4 genotype.
These associations were more evident for black or oolong tea than green tea.
These associations were nearly linear , were stable to model specification , and were detectable below the annual PM2.5 national standard.
These associations were not appreciably altered by adjustment for demographic characteristics , socioeconomic status , self-rated health , or secular trends.
These associations were not explained by psychosocial or demographic factors , or baseline cerebral volume.
These associations were not present in the visual cortex.
These associations were not significantly modified by adult age or perceptual expertise.
These associations were not significant with other cognitive tests , with ACEID , or in African Americans.
These associations were only slightly attenuated when covariates were adjusted , but non-significant once baseline health was further controlled for.
These associations were particularly strong for women and individuals in the lowest equivalent household income group.
These associations were partly accounted for by depressive symptoms , disease burden , physical activity , cognition , body mass index , and smoking.
These associations were remained after controlling for potential confounders , except for rAIx75.
These associations were robust to adjustment for age , sex , employment grade , body mass index , and smoking status.
These associations were significant even after controlling for participant characteristics and risky health behaviors.
These associations were similar after additional adjustment for change in BMI.
These assumptions indicate a museological investment in the capacity and perceived interiority of all participants.
The seated position reduced mean shear rate in the young to that normally observed in old.
These barriers and facilitators were relevant across many types of services and supports.
These barriers provide additional targets for intervention in studies designed to improve sleep in the ICU.
These behavioral gains were accompanied by a decrease in frontal and temporal lobe activity.
These behaviors are disruptive to both patients and caregivers.
These behaviors may increase the risk of exposure to HIV infection in young women out of school.
These behaviours may be important in influencing the pro-inflammatory state seen with ageing.
These benefits are of a similar magnitude to those previously reported for the treatment of AD.
These biases can be excluded by applying a new user design.
These binary constructions have been limiting for everyone , especially those who fall outside the male / female dichotomy.
These biological capabilities are , apart from cancer cells , mediated by different cell types , including endothelial , haematopoietic progenitor and myeloid-derived suppressor cells.
These biomarker indices were expressed in quantitative terms by reporting them as a fraction of the respective controls.
These biomarkers belong to inflammatory and immune , connective tissue , lipid , and hemostasis pathways.
These biomarkers can be applied for diagnosing AD in the prodromal phase of the disease ( mild cognitive impairment ) .
These biomarkers have also been implemented in the revised diagnostic criteria of AD.
These biomarkers may reflect DNA methylation changes derived from changes in the number of a specific leukocyte cell type during aging.
These biomechanical properties likely contribute to the effective and long-lasting correction of facial aging with the high-SMAS technique.
These biophysiologic changes have implications for the pathophysiology of anorectal disorders.
These blocks largely overlap known hypomethylated blocks in colon cancer and we observe that these same regions are similarly hypomethylated in squamous cell carcinoma samples.
These BMI-specific relationships persisted when both fat depots were included in the model.
These brain areas corresponded to the multi-domain task demands.
These calyces mature morphologically and physiologically over the next three postnatal weeks , enabling fast , high fidelity transmission in the VCN-MNTB pathway.
These candidates were then screened in patient systemic circulation to identify detectable candidates in blood plasma.
These can have a significant negative impact on self-esteem and are also potential markers of endocrine or metabolic diseases.
These can influence the impact of drugs prescribed by dentists.
These care levels indicate difficulty in walking or maintaining a sitting posture without assistance.
These cases had no known clinical history of dementia.
These cases have also presented unique challenges requiring alterations in therapy structure and attention to issues of family conflict.
These case vignettes were rated by two psychiatrists specializing in intellectual disability ( ID ) .
These categories suggest foci for potential interventions to promote successful aging in Black older adults.
These categories were Mutual care as freedom and Mutual care as imperative.
These CD28null T cells had significantly shorter telomeres compared to CD28 + T cells.
These cell-relevant characteristics were highly significant over the whole period of one year and may not be related to the existence of primary amino groups.
These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases.
These cells and other leukocytes continue to be the cells of choice in studying autophagy in immunity and inflammation.
These cells are equipped with the lac repressor and exogenous p21 under the control of a lac repressor regulated promoter.
These cells are found in specialized niches that regulate quiescence , activation , differentiation , and cell fate choice.
These cells are maintained and functionally regulated by a specific microenvironment , the stem cell niche.
These cells are relatively easy to obtain , appear to be pluripotent , and are immunologically immature.
These cells can be considered an intermediate stage between embryonic stem cells and adult stem cells.
These cells could thus play a beneficial role protective of injury seen in chronic HIV infection if combination antiretroviral therapy is initiated early.
These cells enter the myogenic program by activating a set of four myogenic regulatory factors.
These cells experience nutrient starvation , acidic stress , hypoxic stress , hyperglycemic stress , osmotic stress and mechanical stress.
These cells have high respiratory reserve capacity and low glycolysis reserve capacity.
These cells have long-term self-renewal capacity , albeit in a unipotent fashion.
These cells may be useful for patients who lack tissue sources for endogenous MSCs.
These cells produce also enzymes degrading hyaluronan.
These cells recapitulated cystic fibrosis transmembrane conductance regulator expression and functions of the parental cells.
These cells share several markers with epiblast / germ line cells and have been named very small embryonic-like stem cells ( VSELs ) .
These cells show a wide range of reactions to various noxious agents , which can be detected in routine stainings.
These cells were able to recapitulate key events of AD pathology including β-amyloid plaques and neurofibrillary tangles.
These cells were a heterogeneous mixture , containing variable percentages of EC.
These cells were negative for smooth muscle actin and CD34 , but tended to be positive for vimentin.
These cells were selected by their plastic adherence and expanded to passage @number@
These cells were stiffer and developed a cytoskeletal structure that differed from that observed upon Lamin A / C introduction.
These cellular power plants generate the energy currency necessary for cells to maintain homeostasis and function properly.
These challenges have increased the urgency for designing a more efficient , cost-effective care delivery model.
These challenges must be addressed to provide optimal care to women affected by female genital cutting.
These changes alter the rate and effort of breathing.
These changes and conditions increase an older adult's vulnerability to and injuries from abuse or neglect.
These changes and decreased cytochrome P450 activity can affect drug metabolism , increasing susceptibility to drug-induced liver injury.
These changes are associated with changes in intracellular as well as local and systemic niches.
These changes are caused by modifications in the composition and arrangement of extracellular matrix in the corneal stroma.
These changes are further exacerbated by the aging population and have made the country vulnerable to many diseases including cancer.
These changes are hypothesized to influence the aging rate of an individual.
These changes are identifiable biochemically regardless of clinical manifestations.
These changes are largely compatible with DTI findings in preclinical and clinical HD patients.
These changes are likely due to overall shaft adaptation to forces acting at the humerus.
These changes are more frequently found in CD8 + T cells , and there are not well-defined markers of differentiation in the CD4 + subset.
These changes are more pronounced in women compared with men.
These changes are of particular relevance for cellular therapy which necessitates standardized products and reliable quality control.
These changes are present in both sexes without distinction between males and females.
These changes are reproducible and have already been described well.
These changes are used to help researchers identify functional changes that contribute to age-related impairments in cognitive performance.
These changes can be attenuated by exercise.
These changes can have negative effects on sexual and urinary function.
These changes cause impaired cell maintenance systems , reduced tissue regeneration , weakening of the immune system and increased risk of malignancy.
These changes coincided with significantly increased NTx ( p < @number@ ) .
These changes complement electroencephalography findings showing that bilinguals devote neural resources earlier than monolinguals.
These changes contribute to better physical function and improved quality of life.
These changes correlated with a lower insulin content ; unlike wild-type or hetE1506K mice , insulin content did not increase with age in homE1506K mice.
These changes could be an effect of the intervention.
These changes decrease the body's ability to mount protective antibody responses.
These changes do not seem to affect the clinical efficacy of FMT in RCDI patients over @number@ months.
These changes entail expression changes of genes that induce age-related phenotypes ( ARPs ) of cells.
These changes exceeded the changes that may be expected due to aging , even in the presence of adequate anti-osteoporosis treatment.
These changes have led to concerns regarding unsafe intracuff pressures in pediatric patients , which may result in postoperative morbidity.
These changes have particular consequences for individual identities and social relations.
These changes include actinic keratosis , thickening and wrinkling , elastosis , telengiectasia , solar comedones , diffuse or mottled hyperpigmentation , and skin cancers.
These changes include decreases in the volume of the thoracic cavity , reduced lung volumes , and alterations in the muscles that aid respiration.
These changes in Dnmt3a levels in the mouse hippocampus may have a significant impact on gene expression and associated cognitive functioning.
These changes in electrical , contractile , and structural properties of the atria have been called \ "atrial remodeling. \ "
These changes in immune functions could alter the pathogenesis of viral hepatitis and autoimmune liver diseases , as well as the development of hepatocellular carcinoma.
These changes in protein turnover resulted in an improved net muscle protein balance in the basal state following RET.
These changes in red-light-PDT and IPL-PDT group were more obvious than IPL group.
These changes in retinal microvasculature may reflect similar pathophysiological processes in cerebral microvasculature in the brains of patients with AD.
These changes in synaptic function are furthermore accompanied by alteration in the GABAergic neurotransmission.
These changes in T- and B-cell composition and function are core manifestations of immune aging.
These changes in the aging lung are important considerations for mechanical ventilation parameters in elderly patients.
These changes in the ALA-PDT group were more obvious than those in the red light group.
These changes in transcriptome profile might contribute to GDM-dependent alterations in cardiac morphogenesis and placental development.
These changes lead to decreased overall physical functioning , increased frailty , falls risk , and ultimately the loss of independent living.
These changes lead to increased pulse wave velocity , especially along central elastic arteries , and increases in systolic blood pressure and pulse pressure.
These changes lead to the expression of RTEs , culminating in their transposition.
These changes likely contribute to reduced PMN efficiency in aging through multiple aspects of PMN function and suggest potential therapeutic opportunities.
These changes may be attributed to anatomic and physiologic changes associated with reproductivity and menopause.
These changes may be caused by activation of @number@ ( PARP1 ) , an enzyme that responds to DNA damage.
These changes may be caused by normal mechanisms.
These changes may be mediated by an HIV-associated ' neuroretinal disorder' , characterized by changes in the retinal nerve fibre layer ( RNFL ) .
These changes may contribute to declining skin immunity in the elderly , including increased skin infections and skin cancer.
These changes may contribute to the development of foot pain , impair performance in functional weight-bearing activities and increase the risk of falls.
These changes may demonstrate natural changes of the distal biceps tendon and may improve our understanding of biceps tendinopathy and its prevalence.
These changes may explain why patients of older age are at an increased risk of infections and infection-associated mortality.
These changes may facilitate photo-aging.
These changes may play an important role in overall health maintenance.
These changes may protect against development of salt-sensitive hypertension.
These changes may provide an opportunity for diagnostic and chemopreventive strategies given the epigenome can be modified.
These changes may reflect internal physiological processes due to diet change within these years and / or ageing.
These changes may underlie the alterations in children's intellectual development that is induced by environmental factors.
These changes might serve as evidence of early phases of neurodegeneration and may explain why smoking can predispose brains to AD and dementia.
These changes occur gradually and are associated with alterations in nitric oxide bioavailability.
These changes occurred without significant changes in BMI.
These changes parallel an improvement in manual dexterity and may reflect developmental changes in functional connectivity.
These changes play a key role in the clinical phenotype of neurodevelopmental disorders like autism and schizophrenia and neurodegenerative disorders such as Alzheimer's disease.
These changes predispose aged individuals to CVDs.
These changes probably make a significant contribution to the behavioral impairment and cognitive decline that often accompany normal aging.
These changes result in many older women having to adapt to a series of complex transitions that can be challenging.
These changes seem to occur independently of physical fitness of old women.
These changes should be accounted for when interpreting single subject VBR data.
These changes should be considered in clinical functional task evaluation.
These changes should be taken into account in clinical practice.
These changes tend to reduce the ability of organ systems to adapt to physiological stressors , particularly in frail older patients.
These changes threatened identities.
These changes were accompanied by decreased accumulation of toxic protein aggregates in ageing worms ' muscles.
These changes were advances of the normal effects of maturation.
These changes were associated with a major inactivation of SSH1.
These changes were associated with higher cumulative hyperglycemia and glucose variability but not with hypoglycemia.
These changes were associated with increased phagocytic clearance of the platelets by macrophages.
These changes were associated with the presence of truncated and phosphorylated TDP-43 species.
These changes were correlated with age but not with visual acuity.
These changes were linear in nature and were not influenced by longitudinal changes in regional tissue volume.
These changes were more than double than those without cuff pressure.
These changes were most probably due to neural and muscular adaptations.
These changes were not significantly different compared between elderly and young healthy controls either.
These changes were observed both in humans and experimental animals.
These changes were related with aneuploidy of cellular population and the presence non-random chromosomal breaks , often in chromosomes @number@ and @number@
These changes were seen despite the lack of self-reported changes in voice.
These changes were significantly more evident in the RA oocytes submitted to IvA.
These changing associations might underlie the weakening of obesity as a cardiovascular risk factor in older persons.
These characteristic elements could provide an important material guarantee for health and longevity of elderly people in the LR.
These characteristics are all influenced quite significantly by sex.
These characteristics are reinforced by the tissue microenvironment and inflammation seems to play an important adjuvant role in both types of disorders.
These characteristics have a significant impact on diabetes and treatment among the elderly , much as diabetes predisposes to these conditions.
These characteristics have major implications for the possible transmission of arboviral diseases and for the planning of surveillance and control programs.
These characteristics of MI should be taken into account when assessing its decay in old age , and when designing mental training for the elderly.
These characteristics of stem cells and their niches give organs an essential advantage to deal with aging , injury or pathological conditions.
These characteristics of tofu from aged soybeans implied a low acceptance by consumers.
These characteristics reflect prenatal environmental adversity and are expected to influence newborn developmental stage.
These characteristics were then integrated to estimate the models by various machine-learning algorithms to predict user's cognitive performance.
These children had an oral health examination , and their parents or guardians answered a questionnaire.
These chronic symptoms are collectively referred to as photoaging.
These circuits operate to coordinate the expression of multiple genes and also to compensate dysfunctions in specific elements of the network.
These circumstances will decrease the sustainability of the LTC Insurance System.
These clinical features and short telomere lengths characterize patients with germline TERT mutations.
These clinical features are due in part to the increase of reactive oxygen and nitrogen species that mediate neurotoxic effects.
These clusters could be easily rebuilt using a small number of variables.
These clusters were strongly related to increased use of community supports , gait aid and carer , and living alone.
These cognitive maps critically depend on hippocampal place cells.
These cohorts were followed up for @number@ @number@ and @number@ years , respectively.
These collagen markers may help differentiate healthy from unhealthy aging.
These combined results suggest that the simultaneous presence of both enantiomers alters the enzyme stereoselectivity.
These common risk behaviors cause preventable , delayed illness that then manifests as chronic disease , requiring extended medical care with associated financial costs.
These common variants have replicable but small effects on LOAD risk and generally do not have obvious functional effects.
These community-based programs showed similar improvements in preventive health , mobility and arthritis outcomes.
These comorbid diseases tend to cluster in a single person , leading to multimorbidity and polypharmacy.
These comorbidities , along with frailty , contribute to the poor outcome of HF in the elderly and pose independent management challenges.
These comorbidities confound the diagnosis , assessment , and interventions for neurocognitive disorders.
These comparative data will eventually be used in the development of new nutritional intervention strategies.
These compared with a c-statistic of @number@ for the published model.
These comparisons were examined at two levels of complexity.
These comparisons were significant at P < @number@
These competing effects may impact total testosterone measurements for the diagnosis of low testosterone , particularly in obese men.
These complaints are often caused by the excessive amount of synovial fluid ( SF ) accumulated in the bursae around the knee joint.
These complaints should be taken seriously because they can lead to falls , injuries , loss of independence , and even death.
These complex fMRI patterns possibly reflect the instable status of these cases with intact behavioral performances despite already existing functional alterations in neocortical circuits.
These complexities are mapped on fractal exponents of DNA walk and human face.
These complex quantitative workflows often include isobaric labeling of enzymatically-produced peptides to analyze their relative abundances across multiple samples in a single LC-MS run.
These complex tauopathies in the elderly deserve specific diagnostic and eventually therapeutic considerations.
These complications were all managed conservatively and resolved spontaneously within @number@ to @number@ weeks.
These compositional differences highlight the role of local-area age structure in identifying and understanding elderly health variation between places.
These compounds are biosynthesized mainly from esterified arachidonic acid through both enzymatic and non-enzymatic free radical-catalysed reactions in vivo , respectively.
These compounds may provide a positive impact on the thermal and electrochemical performance of Li-based batteries as repeatedly described in the literature.
These compounds normally have very low toxicity and have reduced interactions with other pharmaceuticals.
These compounds provide the building blocks of the skin.
These compounds , such as bisphenol-A ( BPA ) , and phthalates , are commonly found in plastic wares.
These concepts can be used to understand disease processes and to develop therapeutic opportunities for the treatment of Parkinson's disease.
These concerns were mainly about the well-being of any children conceived using their gametes and not being able to make contact with them.
These conclusions are interpreted in relation to age-related memory impairment and preventions for hippocampal atrophy.
The second aim was to apply correlation analysis to a range of gait parameters to identify the factors influencing ART.
The second aim was to characterize the cognitive profiles of individuals who transitioned to a more severe disease stage compared with those who did not.
The second aim was to determine extent demographic , health-related , environmental , and cognitive factors influence the change in speech-in-noise recognition over time.
The second aim was to determine what set of self-reported sedentary activities should be used to validly rank people's total sedentary time.
The second aim will be to determine the extent to which semantic processing might be associated with executive functions.
The secondary aim was to assess how ADC values change with age in kidneys with and without VUR.
The secondary aim was to consider the quality of Irish data available for this population-based estimate.
The secondary aim was to determine if differences in adherence and treatment satisfaction existed between the two therapy approaches.
The secondary aim was to identify the risk factors for delirium.
The secondary aim was to perform a selective subgroup analysis when possible differentiating between healthy and sarcopenic subjects.
The secondary analysis also revealed that exercise interventions were beneficial in Alzheimer's disease patients when grouped by disease type.
The secondary analysis revealed that aerobic exercise interventions and aerobic included exercise interventions had a positive effect on cognition in patients with chronic diseases.
The secondary cell death after TBI displays ischemic-like patterns including neuroinflammation.
The secondary endpoint is the correlation between the change in cerebral volume and cognitive function.
The secondary endpoint , reported here , was changes in the Hospital Anxiety and Depression Scale ( HADS ) from baseline to 12-month follow-up.
The secondary endpoints included the response rate of PA at weeks @number@ @number@ and @number@ and photographic assessment at weeks @number@ @number@ @number@ and @number@
The secondary endpoints were functional efficacy domains and inflammatory biomarkers , measured at @number@ and @number@ months , respectively.
The secondary end point was a verbal memory score combining @number@ tests of verbal memory , which is a strong predictor of Alzheimer disease.
The secondary objective includes an evaluation of the influence of the frail phenotype on self-sufficiency in elderly patients after general anesthesia.
The secondary objectives include treatment failure , tolerance , survival , and autonomy.
The secondary objective was to determine the feasibility of adopting a validated nutrition screening tool ( Mini-Nutritional Assessment short-form ( MNA-SF ) ) .
The secondary objective was to identify factors influencing the therapeutic efficiency of these methods.
The secondary objective was to measure the relative positions of the @number@ bony landmarks to better understand functional contributions to LLD.
The secondary outcome measurement was the HV angle.
The secondary outcomes included mental health-related and work-related measures.
The secondary outcomes of days to fall and days to near-fall were analyzed using survival analysis.
The secondary outcome was all-cause mortality.
The secondary outcome was in-hospital complications.
The secondary outcome was mortality @number@ years after CABG or PCI.
The secondary purpose was to compare the 3-D hip joint torques between the trail leg and lead leg.
The second beer , with an original extract of @number@.6° Plato , was dark and very acidic , resembling Lambic.
The second cohort ( n = @number@ ) was taken from the Open Access Series of Imaging Studies ( OASIS ) .
The second component is mainly distributed over the cerebellum , thalamus , and right inferior frontal gyrus.
The second criterion , leading to the subtypes in the four categories , is the localization of the instability in the posterior pelvic ring.
The second dataset contained data from @number@ Turkish migrants aged 65-90 years.
The second discourse , Loneliness - within the discourse of volunteer work , is addressed in reportage articles written by journalists.
The second evaluation variables included the global aesthetic improvement scale , wrinkle severity rating scale , and adverse events.
The second factor , anchored on nine functional improvement HC-QIs , referenced positively , this scale indicates a return to clinical balance.
The second goal was to examine whether the N-glycan profile alters during gestation.
The second group ( n = @number@ ) completed in-person interviews focusing on access to care and their interactions with clients and families.
The second group was formed by @number@ healthy , self-dependent inhabitants of nursing homes , @number@ females and @number@ males , average age @number@ years.
The second group washed with a control facial wash twice daily and applied a control moisturizer each morning and evening.
The second IEEE released standard including UWB definitions is targeted for wireless body area networks ( WBAN ) and was published in @number@
The second is : in vivo measures of neuronal pathology are not widely available.
The second is the average quality of practicing physicians , defined as the fraction of physicians that were trained at top-ranked medical schools.
The second is the demonstration that senescent cells play a causal part in organismal ageing but remain essentially unstudied in a CNS context.
These conditions are also related pathologically through multiple interacting mechanisms.
These conditions are common in women in the post-menopausal period.
These conditions are important contributors to the complex health status of older adults.
These conditions are managed in the general population by healthcare workers with little training in haemophilia.
These conditions can dramatically affect platelet physiology , leading even , as an ultimate event , to the cell number modification.
These conditions can interfere with daily life and normal functioning and lead to negative effects on health-related quality of life.
These conditions could include age-associated dementia and cognitive decline.
These conditions have a direct relationship with cardiometabolic parameters , including insulin resistance , hypertension , hyperlipidemia , and endothelial dysfunction in aging men.
These conditions include disorders of bone homeostasis , impaired bone remodeling , collagen disorders , and medications qualitatively and quantitatively affecting bone strength.
These conditions indicate the use of multiple medications , and are often warranted by clinical guidelines.
These conditions interfere on expression of vascular growth factors and respective receptors causing disturbance in endothelial function.
These conditions may change with age or disease.
These conditions often have major consequences on the quality of life of patients and require adequate evaluation by the primary care practitioner.
These conditions often involve defects in chromatin organization.
These conditions predict disability and poor self-rated health and often are more prevalent in women than men.
These conditions result in exacerbated MOG35-55 peptide-induced EAE.
The second Kreuth Meeting in @date@ was attended by @number@ experts in transfusion medicine , regulators and regulatory authorities from @number@ countries.
The second locus is on 8p11.21.
The second measured the effect of 5-week treatment on hydration by corneometry , on elasticity with the cutometer , and on pigmentation with the mexameter.
The second method employed a combined thresholding , size and shape analysis using T2 -weighted images augmented with visual information from T1-weighted data.
The second method visualized the differences between an average young and old hand by creating a color-coded distance map.
The second modified procedure consisted of mailings to inactive patients selected by physicians.
The second objective is achieved by quality control ( QC ) , which provides in-process quality assurance of the sample profile.
The second objective is to place this historical material in a current perspective where it may be of help in future research.
The second objective was to investigate the consequences of behavior on the self-regulatory systems.
The second objective was to verify the relationships between various dysfunctional cognitions and mental disorders.
The second objective was to verify whether sleep parameters associated with CIND differ between men and women.
The second one included healthful properties , functional components , and carriers.
The second one points to the important role of axons in a bi-directional transport of biological molecules and organelles between the cell body and synapse.
The second part concerns healthy ageing.
The second part of the study was aimed at finding the patterns of everyday cognitive factors that best discriminate between the three groups.
The second patient presented with the classic painful Horner syndrome.
The second perspective considers the assessment of pain in dementia.
The second provides a guide to operationalised patient-centred care.
The second relates to risk factors for Alzheimer's disease and neuropathology.
The second replication phase , in seven independent cohorts , provided no significant replication.
The second sample presented a HRAS point mutation ( c.38G > T ) in codon @number@ resulting in a p.G13V substitution.
The second set of criteria incorporate the use of biomarkers based on imaging and cerebrospinal fluid measures.
The second significant interaction indicated that the positive association between career opportunities and motivation was much stronger for younger employees than for older employees.
The second stage of inflammatory process is associated with reparation and regeneration.
The second study explores whether people living to @number@ years and beyond differ in physical characteristics at a young age from their shorter-lived peers.
The second study used the selected tests to compare baseline performance within 5-year age bands from @number@ to @number@
The second substituted RTS for GCS.
The second task , a binding memory task , required the recognition by participants of a picture according to its spatial location.
The second theme identified the underlying factors of the \ "digital divide \ " between the younger and the older generations.
The second theme of relational life describes the keys to successful transitions as experienced and told by the residents.
The second theme , the outside world , involves the subthemes stigma and human contact.
The second utilized an online survey to measure IPE attitudes , barriers , and facilitating factors among senior administrators in the educational system.
The second was to evaluate the effect of age on weight-bearing perception.
These conflicting observations might reflect dose-and gender-specific differences.
These connections have been established primarily by phenotype-genotype association studies using APOE's three common genetic variants ( ε2 , ε3 , and ε4 ) .
These co-normed data will allow clinicians to compare scores from a-BT with all the tests included in the Neuronorma project.
These consequences are alarming and represent a major setback to academic geriatrics.
These consequences could be minimised if prescriptions for long-term benzodiazepines were decreased.
These conserved miRNAs share a neuroprotective function in the brains of flies and mice.
These consortia typically use meta-analysis to combine multiple studies from many different populations.
These constitute distinct targets for customized treatment in the two conditions.
These constructs may be necessary targets for assessment and interventions among older and young adults.
These contain GFAP and the small heat shock protein , alphaB-crystallin.
The Se content of circulating SELENOP differs between individuals and may provide some important diagnostic information on Se metabolism and status.
The Se content of isolated SELENOP was independent of sex and age ( mean±SD : @number@.4±0.5 ) .
These contradictory forces are difficult to reconcile , creating risk of growing instability and political tensions.
These contrasted results may be due to the influence of factors such as age , obesity , and muscle mass itself.
These contribute to increased hospitalizations and costs.
These contribute to longer hospital stays , loss of independence , and death.
These controversies hinder development and innovation in this field.
These convergent results provide preliminary evidence that neural plasticity can be harnessed to mitigate brain losses with cognitive training in seniors.
These coordinated somatic cell-oocyte interactions attempt to balance cellular metabolism with energy requirements during folliculogenesis , including changing energy utilization during meiotic resumption.
These correlations are significantly stronger than at cross-section.
These correlations changed when controlling for the Clinical Dementia Rating ( CDR ) Scale stages.
These correlations extended over large parts of the temporal , parietal , and frontal cortices.
These correlations have typically been characterized over the entire timecourse ( mean connectivity ) , but the mean correlations between regions vary dynamically.
These correlations resulted in altered GBM ( Glioblastoma Multiforme ) , in particular for CASP1.
These correlations were corrected using the axial length-related magnification effect.
These correlations were seen in both genders.
These correlations with age were similar for men and women , and the yearly change was always higher than in those with the MetS.
These costs can be contained by government policy initiatives.
These could be novel biomarkers associated with ALS risk.
These could represent early consequences of the tau dysfunction that eventually precipitates pathogenesis in humans.
These covariates attenuated , but did not fully explain the associations observed between perinatal complications and aging indicators.
These covariates had already been reported to influence influenza vaccination of elders in previous years.
The secretory pathway of cytokines changed depending on the re-epithelization and the different laser fluences.
These criteria need to be validated.
These criticalities mainly involve the high rate of poly-pharmacy that results from the observation of additional co-morbid conditions in the study population.
These crosslinked UHMWPEs were thermally treated ( annealed or melted ) after irradiation to improve their oxidation resistance.
These cross-sectional data suggest that life-long regular endurance running can partly counteract the aging process in connective tissue by reducing age-related accumulation of AGEs.
These cross-sectional findings remain to be validated prospectively.
These CR-related differences in neural efficiency may underlie reserve against neuropathology and age-related burden.
These crucial functions are ensured by different cutaneous layers , particularly the stratum corneum ( SC ) .
These CSIs could guide future structure-function and alternate hemifield asymmetry analyses by comparing matched areas of similar sensitivity signatures.
The sectorial pattern of peripapillary scleral strain reverses with age , which may predispose adjacent regions of the lamina cribrosa to biomechanical insult.
The sector of previous employment was also a significant factor.
The secular gain in height continued among those born @number@ and later and estimated rates were similar in both sexes.
These current approaches have serious drawbacks as they are either computationally burdensome or provide inaccurate estimates in the tail of the p-value distribution.
These current results demonstrate that widespread administration of this short-term ( 4-week ) evidence-based intervention is feasible.
These cytokines lead to neuronal and glial damage.
These damage-related stimuli induce the secretion of molecular agents collectively termed danger-associated molecular patterns ( DAMPs ) .
These data add new evidence for the use of whey or soy-dairy PBs as targeted nutritional interventions to counteract sarcopenia.
These data add to our growing understanding of how structural maturation of the brain supports vast behavioral changes in executive functions observed across childhood.
These data add to the literature on normal orofacial strength , allowing for more informed interpretations of orofacial weakness in persons with dysphagia.
These data allow the definition of new indices by which the different biomechanical properties of healthy aortas and aortic aneurysms can be characterized.
These data are a valuable resource for the study of the impact of chronic conditions on overall health and aging.
These data are compared with the results of the standard ( on the recommendations of the WHO ) spermogram , reflecting reproductive health.
These data are consistent with FBH1 acting as a negative regulator of RAD51 function in human cells.
These data are consistent with the assumption of an age-related decline in feedback activation from semantics to orthography.
These data are consistent with the previous animal studies showing that peripheral inflammation / infections are sufficient to produce brain Aβ accumulations.
These data are freely available to all researchers interested in pursuing PD research within the Parkinson's Progression Marker Initiative.
These data can assist in 3-D facial reconstructions and aid in establishing the identity of unknown Mi'kmaq individuals.
These data can be useful to incorporate active musculature in computational models , though it may not need to be age-specific in low-speed loading environments.
These data can inform the design of clinical trials using C-peptide values as an end-point for the effect of a given treatment.
These data confirmed the responsiveness of the model and demonstrated that dermal fibroblasts do indeed impact the degree of skin pigmentation.
These data confirm high validity of the MASRI.
These data confirm that FTLD and amyotrophic lateral sclerosis ( ALS ) share a common genetic risk factor on chromosome 9p.
These data confirm the utility of this approach and provide new high-resolution mapping information about variation within the mouse genome associated with hearing loss.
These data corroborate the hemispheric asymmetry reduction in the PFC associated with aging ( HAROLD ) account.
These data could have a significant impact in prevention and rehabilitation programs currently employed in elderly population.
These data could have important clinical implications.
These data cover the entire non-institutionalized population aged ≥65 years in @number@
These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease.
These data demonstrate that eccentric cycling is an effective method for improving leg spring stiffness and maximum power during multi-joint tasks that include stretch-shortening cycles.
These data demonstrate that ET is not associated with cerebellar PC loss.
These data demonstrate that monocytes are key cell candidates for the source of the high soluble inflammatory levels.
These data demonstrate that the HUCB monocytes provide the majority of the efficacy in reducing infarct volume and promoting functional recovery.
These data demonstrate the potential for rapid and accurate diagnosis of Ps. aeruginosa infection from sputum samples.
These data do not demonstrate the strong and significant changes in sex ratio observed elsewhere.
These data do not support prescribing vitamin D supplements to older sedentary men to prevent physical function decline.
These data do not support the pathogenicity of several EIF4G1 variants in PD , at least in the French population.
These data emphasize the need for the deployment of innovative prevention and treatment strategies for knee OA , especially among younger persons.
These data emphasize the potential importance of adequate postexercise Leu ingestion to enhance the response of aging muscle to preventive or therapeutic exercise-based rehabilitation programs.
These data establish a primary role for somatic instability in DM1 severity , further highlighting it as a therapeutic target.
These data further add to our knowledge about structural lateralizations and their development in the maturing brain.
These data have been used to generate age-specific reference ranges for both measurements and indices.
These data have potentially important implications for clinical practice.
These data highlight the complex interplay between objective functional capacity , neurocognitive ability , subjective cognitive symptoms , and functional dependence.
These data highlight the fact that mechanisms that guide metastatic progression may be linked to those that mediate therapy resistance.
These data identify decorin degradation and neutrophil elastase as potential therapeutic targets for mitigating sun exposure-induced collagen fibril degradation in human skin.
These data identify prelamin A and 53BP1 as new targets of rapamycin that are associated with human longevity.
These data illustrate that it is not feasible to have a single exercise prescription for older adults with compromised function.
These data implicate causative PURA mutations responsible for the severe neurological phenotypes observed in this syndrome.
These data imply independent regulation of UGT1A1 and 1A6 where activity has matured after @number@ months to @number@ year.
These data imply that aging and the AD-associated neurodegenerative process are not the major factors contributing to the retrotransposition processes of active LINE1 repeats.
These data imply that income relates most strongly to brain structure among the most disadvantaged children.
These data indicate an inhomogeneous up-regulation of the TSPO system during ageing and AD.
These data indicate a potential role of the nuclear translocation of apoptotic signals in the induction of apoptosis.
These data indicated that the prevalence of DRPs is high among BPH patients.
These data indicate that aging may play an important role in pathogenesis of human AOBs loss.
These data indicate that an FCT program is effective in improving measures of function and reducing physical frailty among frail older adults.
These data indicate that Cat316 binding to C4S in the extracellular matrix can restore plasticity and memory in the same way as chondroitinase ABC digestion.
These data indicate that cathepsin L may be involved in 6-OHDA-induced apoptosis and Parkinsonian neurodegeneration.
These data indicate that HTT is involved directly in membrane dynamics , cell attachment , and motility.
These data indicate that hyposalivation is closely related to hypogeusia.
These data indicate that in addition to promoting epithelial tumor growth , senescent fibroblasts also can promote carcinogenic initiation.
These data indicate that LH increases cutaneous endothelial and myogenic activity , while decreasing neural activity.
These data indicate that LV dysfunction is observed following PE and that advancing age does not increase the magnitude of this response.
These data indicate that moderate increases in body temperature during passive heat stress do not differentially compromise cognitive function in younger and older adults.
These data indicate that pathological changes in the cerebellum are a part of the pathophysiological cascade of events in both forms of ET.
These data indicate that rapamycin indirectly modulated immunoproteasome through the suppression of inflammatory response pathways.
These data indicate that reduced RSU-1 might induce Ras expression , which subsequently could provoke Ras-induced senescence.
These data indicate that specific treatment regimens for the elderly might therefore be considered.
These data indicate that the mechanism by which retinoids improve aged skin , through increased collagen production , involves down-regulation of CCN1.
These data indicate that the optimal window of opportunity for therapeutic intervention in women is early in the endocrine aging process.
These data indicate that the signal pathway to ROS generation in replicative aged skin cells can be stimulated by reduced PTEN level.
These data indicate that VEGF-mediated angiogenesis following mechanical stress may be a critical step within the series of pathological events in LFH.
These data indicate the NK3-R as an important target to predict and improve learning and memory performance in the aged organism.
These data justify a range of strategies , and combination therapies , to combat the degenerative and vascular determinants of cognitive decline and dementia.
These data justify some predictions on the evolution of life expectancy taking in account also socio-economic factors.
These data may also have implications for treatment of stroke patients with language impairment.
These data may help explain insulin's complicated roles in atherosclerosis in the elderly.
These data may provide a novel strategy for therapy in COPD.
These data might have important implications in pharmacology of PARP-1 inhibitors as well as clinical oncology and aging.
These data might serve as a reference baseline for clinicians and pathologists.
These data points were plotted against subject age for statistical analysis.
These data point to a need for further study into the determinants of functional outcomes in ICU survivors.
These data presented here demonstrate that 15d-PGJ₂-immobilized beads are effective tool for purification of PGJIFs directly from crude cell extracts.
These data presume that the cytoskeleton is loose.
These data provide clear and systemic structures for early retinal development in human.
These data provide comprehensive insights into the molecular pathways involved in acute stress , recovery , and adaptive muscular responses to endurance exercise.
These data provide confidence in nanomechanotransduction for stem cell differentiation without dependence on soluble factors and complex chemistries.
These data provide evidence that during the centriole duplication cycle NQO1 may provide NAD + for Sirt2-mediated deacetylation of microtubules.
These data provide evidence that mbKitL targeted vaccination is an effective means of inhibiting tumour angiogenesis and growth.
These data provide evidence that MYBPC3 mutations constitute the preeminent cause of HCM and that they are phenotypically indistinguishable from HCM caused by MYH7 mutations.
These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular disease.
These data provide important guidance for design and deployment of care technology for the home.
These data provide important initial evidence that the capacity to apply episodic foresight in a functionally adaptive way is impaired in late adulthood.
These data provide key insights into astrocyte-specific contributions to AD , and we present this data set as a publicly available resource.
These data provide the first large-scale demonstration of links between inflammatory markers and LTL in an older population.
These data raise the possibility that during ageing very short telomeres with very poor @number@'-overhangs can reach a critical point for functional telomeres.
These data represent a basis for future research on the N-glycome of placental proteins in different ( patho ) physiological conditions.
These data reveal a novel linkage between limited oxidant exposure and altered cellular redox homeostasis that results in impairment of TGF-β signaling.
These data reveal a prospective therapeutic potential for novel substrate-derived sirtuin inhibitors.
These data reveal that the estimated progenitor allele length is the major modifier of age of onset.
These data serve as input for automated algorithms identifying medication reconciliation discrepancies , potentially inappropriate medications ( PIMs ) , and potentially inappropriate regimens.
These data showed that creatine improves health and longevity in mice.
These data showed that sputum neutrophila can be dissociated from airway symptoms and could create a favorable background for the development of age-related lung diseases.
These data showed that the overexpression of GSN in H9c2-induced cardiac hypertrophy and increased the pathological hypertrophy markers atrial natriuretic peptide brain natriuretic peptide.
These data show how collagen crosslinking can modulate tissue fibrosis and stiffness to force focal adhesions , growth factor signaling and breast malignancy.
These data show that activation of autophagy is a promising approach to protect against alpha-synuclein pathology and likely acts by targeting one specific alpha-synuclein species.
These data show that common genetic variability has a role in the disease.
These data show that mIndy is increased in liver of obese humans and nonhuman primates with NALFD.
These data show that NAM has potent antioxidative as well as anti-senescent effects.
These data show that particular anti-oxidative enzymes function as protective factors in chronically sunlight-exposed human skin.
These data strongly suggest that the p73-ATG5 axis represents a novel , key pathway for regulating lipid metabolism through autophagy.
These data strongly support the important role of p.R47H in AD risk , and suggest that this rare genetic variant is not related to FTD.
These data suggest a differential effect of sex on hip geometry with evolving glucose intolerance.
These data suggest age does not affect the capacity to acclimatise to exercise-heat stress in highly trained adults undergoing short-term heat acclimation.
These data suggest a link between lifelong endurance exercise and myocardial fibrosis that requires further investigation.
These data suggest a link between specific gene expression clusters and Alzheimer's disease-associated neuropathology in the prefrontal cortex.
These data suggest a novel role of human 2N / 4R tau in microglial activation.
These data suggest a substantial contribution of inflammation in progressive impairment of joint function with age.
These data suggested that HMB in combination with @number@ weeks of RT decreased AFM in elderly men.
These data suggested that MIC-1 / GDF15 may be a marker of all-cause mortality.
These data suggested that Rab1A may be involved in the pathogenesis of human lung cancer in an mTOR- and MAPK-independent manner.
These data suggest Golgi fragmentation could be an upstream event triggering tau hyperphosphorylation through golgin-84 deficit-induced activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase.
These data suggest higher urine PIIINP levels associate with CKD progression independently of eGFR and ACR in older individuals.
These data suggest inherited defects of DNA repair may provide valuable insight into physiological ageing.
These data suggest OI symptoms in older adults may reflect various important underlying health deficits , indicative of increasing levels of frailty.
These data suggest older adults exhibit more EFL and increase EELV earlier during exercise compared to younger adults.
These data suggest PAPP-A as a potential therapeutic target for diabetic nephropathy.
These data suggests a dysregulation of Glu signaling in PM carriers , which would likely contribute to the development and severity of FXTAS.
These data suggest that , after accounting for cigarette smoking , adherence to a set of healthy behaviors may have considerable health benefits.
These data suggest that age-dependent increase in tremor amplitude is not restricted to older people but occurs in all adult age groups.
These data suggest that aged garlic extract may be useful for preventing diseases associated with reactive oxygen species.
These data suggest that age-specific guidelines may be necessary.
These data suggest that aging is characterized by a higher expression of Let-7 family members that may downregulate genes related to cellular proliferation.
These data suggest that a reduction in C9orf72 protein may be a consequence of the disease.
These data suggest that AT1R activation contributes to the reflex VC response in aged but not young skin.
These data suggest that CAMP is required for maintaining kinetochore-microtubule attachment during bi-orientation.
These data suggest that CDR1 could be a new biomarker for PCa identification.
These data suggest that characteristics of WM CVR are different from that of GM and caution should be used when interpreting pathologic WM CVR results.
These data suggest that close attention should be paid to young people even in mild or moderate depression.
These data suggest that compared to multiple steppers , single steppers recruit a larger proportion of the available motor unit pool during balance recovery.
These data suggest that developmental increases in neural sensitivity to face identity in face-selective regions improve perceptual discriminability of faces.
These data suggest that DJ-1 works in parallel to the PINK1 / parkin pathway to maintain mitochondrial function in the presence of an oxidative environment.
These data suggest that excess O-glycosylation on APP by GalNAc-T6 inhibits Aβ production.
These data suggest that FMR1 CGG repeats are not a genetic risk factor for ET.
These data suggest that frailty is associated with increased innate immune activation and abnormal lipidomic profile.
These data suggest that gal-7 could potentiate the phenotype of HER-2 positive primary breast cancer.
These data suggest that HRT positively influences a limited number of olfactory and cognitive measures during menopause.
These data suggest that HS- @date@ inhibit human prostate cancer progression and angiogenesis by inhibiting the expression of HIF-1α and VEGF.
These data suggest that in aged skin , IL-1β signalling is diminished due to altered expression of IL1B and decoy receptor gene IL1R2.
These data suggest that increased risk of spontaneous abortion and congenital abnomalies has not been observed.
These data suggest that LA-peptide conjugates may have cosmeceutical application as anti-melanogenic and anti-aging agents.
These data suggest that learning different types of information depend on associated reward values and internal motivational drives , possibly determined by personality traits.
These data suggest that low intensity aerobic exercise may be useful to prevent the decline of antioxidants linked with aging.
These data suggest that microglia undergo an age-associated decrease in microglial ability to interact with Aβ fibrils.
These data suggest that NE indirectly plays a role in skin photoaging through MMP activation.
These data suggest that older suicide attempters have a deficit in risk-sensitive decision-making , extending observations in younger adults.
These data suggest that one source of heightened emotionality in adolescence is a diminished ability to cognitively down-regulate aversive reactions.
These data suggest that organs and systems reflect the aging status of an individual and may be a useful tool for evaluating health status.
These data suggest that RECQ5 removes RAD51 filaments stabilizing stalled replication forks at CFSs and hence facilitates CFS cleavage by MUS81-EME1.
These data suggest that reduced sleep time may contribute to the severity of hypertension.
These data suggest that regions affected by α-synuclein pathology may display enhanced vulnerability and cell loss if Cu-dependent protective mechanisms are compromised.
These data suggest that relative TL is tissue-independent in DC and possibly in the other IBMFS.
These data suggest that sclerostin levels are initially increased after SCI in response to mechanical unloading.
These data suggest that signal transduction of acute exercise may be impaired with aging.
These data suggest that sonographic markers cannot be substituted for AMH in determining LMT.
These data suggest that T cells may play a critical role in mediating MPC function.
These data suggest that the CAVI is a sensitive marker of the arterial aging process , above and beyond conventional upper arm BP.
These data suggest that the habitual intake of flavanols can support healthy cognitive function with age.
These data suggest that the inflammatory response to unaccustomed exercise increases with age.
These data suggest that the neuroprotective effect of hUCB MNCs can be enhanced by repeated cell administrations.
These data suggest that there are tradeoffs between potential benefits and harm from anti-oxidant dietary supplementation.
These data suggest that the renin-angiotensin system plays a critical role in mechanisms underlying cachexia in chronic disease states.
These data suggest that this approach might have sufficient resolution to discriminate between discrete genetic FCD backgrounds , which will potentially aid in patient management.
These data suggest that total daily activity in very old adults declines more rapidly with increasing age.
These data suggest that TXNIP-induced oxidative stress may be a critical modulator of tissue resistance to NO , a fundamental basis for cardiovascular disease.
These data suggest that VDR is a better predictor than serum 25OHD concentration of intramuscular IL-6 gene and protein expressions.
These data suggest the compensatory effect of exercise on decline in old age.
These data suggest the existence of compensatory mechanisms during physiological brain aging that disappear in \ "AD-like \ " animals.
These data suggest the need for more targeted HF prediction and prevention efforts.
These data suggest TPL2 is a novel target for improving the metabolic state associated with obesity.
These data support a role for intrinsic factors , besides the extracellular environment in the defective SC function in aged skeletal muscles.
These data support further exploration of genetic influence on longevity in the Okinawans.
These data support further investigation of treatment targeting aldehydes for CSA.
These data support proposals that P1 indexes attentional suppression , which is less efficient in older adults.
These data support suggestions that fMRI spatial navigation tasks may be useful for staging of progression in MCI.
These data support the concept that increased DNA content increases neuronal susceptibility to degeneration and Alzheimer pathologies.
These data support the ethical and respectful approach to potential DCD donors in the authors ' center , including regular comfort therapy.
These data support the hypothesis that GCs contribute to cognitive ageing differences from childhood to the early 70s , partly via brain WM structure.
These data support the hypothesis that perivascular solute drainage from the brain is altered both in the ageing brain and as a consequence of CAA.
These data support the need for joint accountability and collaboration for future readmission reduction efforts between hospitals and their SNF partners.
These data support the need to re-evaluate the epidemiology , pathophysiology , and therapy of HF patients with concomitant DM.
These data support the topical application of DSG for relief of OA knee pain in elderly and younger patients.
These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process.
These data support the view that regular PA plays an important role in maintaining functional status during aging in older women.
These data , therefore , suggest that systemic administration of FGF2 could have a potential therapeutic application in AD.
These data together indicate that the innate immune system of the aging hippocampus is highly responsive to the gonadal hormone milieu.
These data were analyzed using an analysis of covariance.
These data were collected at baseline and every @number@ months for up to @number@ months or until death.
These data were collected by interviews conducted before ( @date@ and @date@ ) and after ( @date@ and @date@ ) the establishment of LTCI.
These data were considered by an expert panel to determine the presence or absence of delirium and dementia ( reference standard ) .
These data were correlated with confocal analysis of spindle-chromosome complex.
These data were estimated by Logit model.
These data were linked to country data on income inequality , public health expenditures , healthy life expectancy , and adult mortality.
These data were linked to official death records.
These data were paralleled in murine brains.
These data were supplemented by qualitative data obtained through in-depth interviews , focus groups and storytelling.
These data were then subjected to auditory ERPs extraction and thorough statistical analysis.
These data were used to develop a model that can predict thymic function during normal aging or in individuals therapeutically or accidentally exposed to radiation.
These data , while incomplete , support a hypothesis that similar to aging , HFPEF is a systemic process.
These data will be useful for evaluating the functional consequences of missense MUTYH variants detected in patients with suspected MAP.
The sedative effects of these drugs on postural control are reversible , as was proven in intervention studies where FRIDs were withdrawn.
These deal with fMRI developmental studies and discuss methods ( Luna et al.
These deaths represented a loss of over @number@ @number@ YPLL and $ 119 million in lost productivity.
These declines with age and lean direction were associated with declines in response initiation , execution and geometry.
These decreases are suitable for adaptation to the insufficient CNS activity induced by energy deficiency.
These defects may alter distinct phases of the wound-healing process , including epithelial migration , granulation tissue formation , and tissue remodeling.
These defects may play a central role in pathophysiological processes predisposing elderly subjects to dementia.
These defects parallel reduced PI3K-AKT signaling , which can significantly abrogate bacterial killing , but does not affect cytokine responses.
These defense systems tend to decline during aging , facilitating the manifestation of aggregate deposition diseases.
These deficiencies were prevented by the ingestion of theanine , an amino acid in tea , under stressed conditions.
These deficits are already evident at an early age and persist in older age cohorts ( despite an overall age related decline ) .
These deficits are increased during the acute phases of the illness and worsen over the course of BD.
These deficits are not associated with atherosclerosis but are accompanied with altered astroglial activation , neurogenesis , cyclooxygenase-2 immunoreactivity and increased plasma IL-6.
These deficits exacerbate fall risk and difficulties with mobility , especially during complex or dual-task walking.
These deficits in reactivity coincide with higher vulnerability of these regions to AD-type pathology.
These deficits , in turn , lead to impaired functioning in complex listening environments.
These deficits may disrupt a number of cognitive processes , such as episodic memory , that are important for the execution of daily activities.
These deficits were associated with reduced neurotrophin signaling , defective learning and memory and impaired synaptic plasticity.
These deficits were restored by the transfection of wild-type PKP2 , but not of BrS-related PKP2 mutants.
These degenerative changes are intimately associated with quality control mechanisms.
These demonstrated increased hepatic lipid accumulation , higher levels of transcription factors important in lipid regulation , and greater oxidative stress.
These dengue outbreaks affected several locations with over @number@ notifications.
These dependencies often involve multiple levels of representation and abstraction , built up as infants gain experience with their native language.
These described methods are used in genotoxicity assays of compounds of interest or in analyzing DSB repair after exposure to drugs or radiation.
These describe the subject's sensitivity to rapid flicker and the absorption of blue light by the lens.
These detrimental features are also observed in high birth weight offspring from mothers who were obese or consumed a high fat diet during gestation.
These developmental changes are suggested to result from infants ' advancing linguistic experience and parallel auditory cortex maturation.
These developments highlight the complex and dynamic relationships among perception , attention , and memory.
These developments represent huge challenges to national and community-based health services.
These developments will have a direct effect on clinical practice when genome sequencing becomes a routine and integral part of disease diagnosis and management.
These deviations are considered as adaptations to the energy deficiency observed in aged patients with DM.
These differences among the three groups remained significant after adjusting for age and height ( P < @number@ ) .
These differences appear to be mediated in part by the gastrointestinal behaviour of these products.
These differences are due to a combination of demographic , environmental and other unidentified factors.
These differences are interpreted in terms of qualitative developmental changes in reactive goal-setting strategies.
These differences are not simply biologically mediated ; both physiological and sociocultural factors contribute.
These differences are orchestrated by the interplay between genetic , hormonal , and environmental influences.
These differences could have ramifications to autoimmunity as well as immunology against infection and tumors.
These differences did not appear to be explained by educational level ( Men : p = @number@ women : p = @number@ ) .
These differences did not however remain through further subdivision by hyperlipidemia and normolipidemia.
These differences disappeared after adjustment for current body size.
These differences have led to different predictive disease models and can influence the assessment of aging and environmental modifiers.
These differences , however , were not significantly correlated with age , memory span , or hearing status.
These differences include age-related increases in PFC activation magnitude and reorganized PFC functional connectivity ( fC ) patterns.
These differences indicate marked change of autonomic regulation.
These differences in sleep disruption between aMCI and naMCI may be related to differences in the pathology underlying these MCI subtypes.
These differences in susceptibility are consistent with species-specific discrepancies between observed and allometrically-predicted life spans and are compatible with the oxidant theory of aging.
These differences in the incidence and pattern of rib cartilage calcification need appropriate preoperative attention.
These differences may be characteristic of a combination of social , biological , and environmental contexts.
These differences may be significant in terms of their later development of metabolic conditions.
These differences may contribute to brain atrophy and progressive cognitive changes in BD.
These differences may reflect differences in underlying mechanisms of pain in the @number@ periods.
These differences persisted after accounting for sociodemographic factors and comorbidities , but largely became nonsignificant after accounting for physical capacity.
These differences persisted after adjustment for age , sex , BMI , smoking and medications.
These differences persist even after controlling for a number of life-course events and transitions.
These differences preceded more extensive cognitive decline present at the age of @number@
These differences reflect the impact of each country's social policy environment on service users ' expectations.
These differences remained after controlling for covariates such as birth year , career length , age at debut , height , and player position.
These differences remained statistically significant after adjusting for MMSE and demographic characteristics.
These differences result in the need for varied interventions.
These differences should be remembered when the choroidal thickness is evaluated in pediatric patients with retinochoroidal diseases.
These differences suggest that a simple maximal torque test is not sufficient to characterise older adults ' abilities in relation to package opening.
These differences suggest that caution should be used in the interpretation and comparison between studies.
These differences tended to be the result of delay in tooth eruption in thin and stunted adolescents.
These differences were already apparent after week @number@
These differences were consistent over @number@ y.
These differences were eliminated after adjustment for BF% , aerobic fitness , age and puberty.
These differences were equivalent to being @number@ year younger in age.
These differences were equivalent to those observed in women who are 1-2 years apart in age.
These differences were explained by @number@ and @percent@ , respectively , by vigorous-HPA-related favorable impacts on other cardiovascular risk factors.
These differences were independent of body mass index and waist circumference.
These differences were not explained by age or disability.
These differences were not present when male hands were compared with female hands.
These differences were not significant in the two higher 3MS tertiles.
These differences were reduced or nonexistent in the BCE-ECM-treated explants.
These different environmental factors interact with GORD pathogenesis in a potentially negative way.
These differentially abundant proteins are involved in the regulation of apoptosis , cellular senescence and inflammatory response.
These different lines of evidence suggest that NCD disease mechanisms are in part shared.
These different perspectives are crucial when assessing and planning psychiatric and mental health services.
These difficulties affect the development of phonologic representations.
These difficulties produce frequent failures and waste of human and economic resources.
These discoveries suggest that IIS inhibitors can serve as new drugs for the treatment of neurodegenerative maladies including AD and HD.
These discrepancies may be attributed to the occurrence of different sub-groups of the disease.
These discussions are subjected to a framing analysis.
These discussions are subjected to a framing analysis.
These disease burdens severely diminish patients ' quality of life and incur heavy healthcare utilisation.
These diseases are among the major health care problems in terms of socio-economic costs.
These diseases are characterized by impaired or altered function at the tissue and cellular level , which is a hallmark of the aging process.
These diseases are common in the elderly and share some pathological features.
These diseases are currently maintained using long term administration of conventional drugs which are not curative and reduce the life quality of patients.
These diseases have emerged concomitantly with profound social changes over the past @number@ years.
These diseases impact quality of life of the elderly and consume a large portion of health care costs.
These diseases progress in situations associated with immune inflammation.
These diseases share in common target-organ insulin resistance with a constellation of molecular and biochemical abnormalities that lead to organ / tissue degeneration over time.
These disorders are also frequently encountered in the aged population.
These disorders are challenging in terms of diagnosis and treatment.
These disorders can start as early as childhood , and such early onset increases the likelihood of early morbidity and mortality.
These disorders have a pathology distinct from those of primary insomnia , and require a different treatment strategy.
These disorders have common molecular mechanisms that can be targeted therapeutically.
These disorders present with a variable extent of cognitive impairment and alpha-synuclein is being explored as a biomarker in CSF , blood serum and plasma.
These disparities underscore the need for continued research addressing socioethnic cardiovascular differences and the biobehavioral mechanisms involved.
These disruptions are associated with episodic memory demonstrating their behavioral and clinical relevance in AD.
These disruptions have not been empirically related to psychological and cognitive pathways to suicide.
These distance-related connectivity profiles illustrated a dysfunctional pattern in aMCI , which extended our knowledge of this pathological aging process.
These distinct adaptations have provided a rich source of scientific discovery ranging from biochemistry and genetics to optics and physics.
These distinct characteristics add to accumulating evidence that a dysexecutive subgroup of AD may have a unique underlying pathophysiology.
These distinctions can be useful as the implications of clonal hematopoiesis depend almost entirely on the clinical context in which it is identified.
These distinct roles that Sox2 plays involve delicate regulatory networks consisting of other master transcription factors , microRNAs and signaling pathways.
These disturbances facilitate the realization of promotion and progression stages ofcarcinogenesis.
These disturbances were found particularly in subcortical regions and frontal cortex.
These diurnal-type preferences are thought to be relatively stable , but follow-up studies are sparse.
These diverse applications highlight the capacity for multiphoton tomography and femtosecond laser nanoprocessing tools to advance drug delivery research.
These diverse properties are attributed to distinct macrophage subtypes and polarization status.
These DNA damage photoproducts are repaired by a process called nucleotide excision repair , also known as UV-induced DNA repair.
These DNA repair defects represent genetic aberrations that are specific to cancer cells and not present in healthy tissues.
These DNA repair enzymes maximize the rate of DNA repair and provide a more efficient response to carcinogenesis.
These domains demonstrated acceptable concurrent validity with two established personality measures , the NEO-Five Factor Inventory and Life Orientation Test-Revised.
These domains were generally consistent across demographic subsets of informal caregivers.
These drawbacks can be overcome by various approaches , such as chemical modification of the vitamins and the use of new colloidal drug delivery systems.
These drugs are often combined with rituximab and can be prescribed in combination with chemotherapy.
These drugs block L-type calcium channels , with the long-acting or latest generation dihydropyridines being the most effective of this group.
These drugs interrupt the negative feedback loop of ANG II on the RAAS cascade , which results in increased production of angiotensins.
These dynamics of caregiving decision-making offer insight in understanding evolving filial piety in urban China.
These dysregulated genes were enriched for telomere-contacting promoters , suggesting a potential mechanism for telomere-dependent regulation of homeostatic gene expression.
These dysregulated miRNAs may affect adipocytokine signaling and forkhead box protein O signaling.
These earlier ages reduce differences between modern humans and fossil hominins for these developmental events in second and third molars.
These earlier patients may have early cognitive losses consistent with mild cognitive impairment ( MCI ) or may be completely asymptomatic.
These early efforts and achievements have greatly contributed to the development and clinical application of ( @number@ ) F-FDG PET in oncology.
These early findings would confirm the protective role of melatonin against several chronic diseases.
These early manifestations can be seen as \ "brain failure \ " and their co-occurrence suggests that they may share a common underlying mechanism.
These early studies proposed a classification of the SEC in six stages.
The seedcakes are a potential source of natural bioactive substances : antioxidants , protein , and carbohydrates.
The seedcakes due to their antioxidant and anti-inflammatory activities have potential application in anti-aging , moisturizing , mitigating , and protective cosmetics.
The seed may only germinate if the soil is fertile.
The seed-similar miR-137 regulated VGluT2 expression in mouse neurons.
These effects and the reduction of LPS-induced endothelial apoptosis by thiazolidinediones depend on TERT.
These effects appeared to be amplified among individuals identified as having mild cognitive impairment ( MCI ) at baseline ( p < @number@ ) .
These effects appear particularly important in persons hospitalized for @number@ or more days per year.
These effects are associated with increased APWV , but are attenuated by rhGH therapy in GHD.
These effects are dependent on HIF-1 , which transactivates target genes encoding metabolic enzymes and membrane transporters.
These effects are due to endogenous oxidative stress , as antioxidants will reverse all of them.
These effects are independent of mTOR and opposite in the direction predicted by the known activation of mTOR by Rhes.
These effects are in part reversible with weight loss.
These effects are likely to be mediated by the enhanced nuclear matrix association of the ubiquitylation-resistant RAD51.
These effects are mediated by activation of the water channels AQP1 and NHE-1 , and a PKCbeta-mediated intracellular signaling pathway.
These effects are mediated by differential protein interactions of LRRK2 with a guanine nucleotide exchange factor , ARHGEF7.
These effects are mostly due to ultraviolet ( UV ) rays ( UVA , 320-400 nm and UVB , 280-320 nm ) .
These effects are possibly due to different linkage disequilibrium patterns or differences in comorbid risk factors mediating SNP effect on risk for AD by group.
These effects are reversed by PKR downregulation ( using a specific inhibitor or in PKR knockout mice ) .
These effects are significantly influenced by ablation or ectopic expression of PPARγ , indicating that PPARγ is directly involved in the regulation of SIRT1 stability.
These effects can be counteracted by estrogen treatment.
These effects can be inhibited using a sialidase inhibitor.
These effects correlated with CR-mediated increases in SIRT1 and decreases in p53 expression levels.
These effects could also contribute to minimizing the impact of memory impairment.
These effects could explain the beneficial effects of these drugs in various cardiovascular diseases associated with endothelial injury and aging.
These effects depend on several signaling pathways modulated by Wip1 phosphatase in a spatial and temporal manner.
These effects depend upon many factors , including the seizure type , age of seizure occurrence , sex , and brain region studied.
These effects did not disappear after cessation of the NT-proBNP-guided strategy on the long-term.
These effects disappeared within @number@ months of stopping the probiotic intake.
These effects explained @percent@ of the variance in gmax error for the Actigraph system.
These effects for people with CLBP were d = @number@ for subgroup of older and d = @number@ for subgroup of younger participants.
These effects have mostly been shown in processes such as WM and attention , whereas studies investigating transfer to executive functions have been scarce.
These effects include falls and confusion and may exacerbate dementia-related symptoms.
These effects , including the prelamin-A-mediated increase of nuclear 53BP1 , can be reproduced by rapamycin treatment of cells from younger individuals.
These effects involve reducing hyaluronidase , elastase , collagenase , and MMP-1 activities , as well as inhibition of melanin production and tyrosinase activities.
These effects may act in combination with other factors , like aging , metabolic diseases and the genetic makeup of the host.
These effects may have some clinical relevance in the research of drug resistance or cell aging.
These effects may persist after a sustained virologic response ( SVR ) is achieved with HCV therapy.
These effects of KL are mediated through cAMP-PKA-dependent phosphorylation of transcription factor CREB.
These effects of Klotho may play important roles regarding calcium reabsorption in the kidney.
These effects of ROBO1 appear to be unrelated to brain mechanisms underpinning reading ability , at least by adolescence.
These effects of telomerase and telomere length on stem cell behaviour anticipate the premature ageing and cancer phenotypes of telomerase mutant mice.
These effects relate to age-related gradual accumulation of stressors that result in increasingly damaged biomolecules which eventually compromise cellular homeostasis.
These effects should be validated in future studies.
These effects suggest a twofold dynamic of terminal changes in NA.
These effects suggest that L-PHP may benefit pancreatic β cells and diabetic therapy in clinic.
These effects typically include constipation , dry mouth , blurred vision , dizziness and slowing of urination.
These effects were associated with enhanced expression of the mitochondrial master transcriptional coactivator PGC-1α and its target genes.
These effects were associated with suppressed AKT activity and CREB activation and increased p53 expression.
These effects were attenuated by BFF122 and mimicked by exogenously applied KYNA ( @number@ μM ) .
These effects were attributed to de novo synthetic pathways ; however , the impact on Aβ degradation was not explored.
These effects were consistent after controlling for age , education , and gender.
These effects were different from those of simply decreasing the overall stimulus level , which caused significant shifts in latency across the entire S-ABR.
These effects were driven , in large part , by associations in older adults.
These effects were due to elevated nSMase-2 mRNA and protein and appeared to be direct.
These effects were identified up to @number@ years before diagnosis , and worsened thereafter.
These effects were increased by presenting birds in pairs so as to highlight differences among families during study ( Experiment @number@ ) .
These effects were independent of each other.
These effects were largest when there was a discrepancy between Time @number@ reading ability and Time @number@ VIQ.
These effects were lower for older adults compared with a younger , normal-hearing adult sample ( N = @number@ ) .
These effects were mediated by pretask worry such that , for those in the entity condition , higher worry was associated with lower performance.
These effects were reproduced by chronic dosing with low levels of Cu via drinking water without changes in Aβ synthesis or degradation.
These effects were rescued by the addition of human Aβ₄₂ , suggesting that endogenously produced Aβ is needed for normal LTP and memory.
These effects were significantly alleviated by @number@ ng / mL allicin co-treatment.
These effects were similar for positive and negative emotions , and they were independent of age-related differences in cognitive , affective , and personality measures.
These effects were statistically equivalent in young and older adults , suggesting that the syntactic representations underlying sentence production are unaffected by normal aging.
These effects were substantially explained by improvement in depressive symptoms.
These effects were weaker in e4 carriers , and e4 carriers did not show greater pupil diameter to remembered words.
These efforts facilitated study implementation and enhanced recruitment resulting in accrual of a biracial and socioeconomically diverse cohort of @number@ participants.
These efforts have provided a base of knowledge of the critical factors to consider in designing and implementing new longitudinal studies in older adults.
These efforts lead to the identification of ML216 and related analogs , which possess potent BLM inhibition and exhibit selectivity over related helicases.
These elders demonstrate a relatively comprehensive but simple set of practices that can enhance our vitality and promote longevity sustainably.
These elevated antioxidant activities following oral administration of yam dioscorin in vivo may reflect traditional juvenescent uses with the potential for anti-aging treatments.
These emergent mechanisms of actions implicate AXT as a promising therapeutic agent for neurodegenerative disease.
The seemingly similar developments have been observed with different experimental protocols in the different age groups , respectively.
These emotional signals can constitute an alert against toxic substances , and they may play a major role in food selection and nutritional intake.
These enable greater choice in participation , and contribute to the sustainability of community resources serving ageing populations.
These endogenous rhythms dampen with age and thus compromise temporal coordination.
These enhancements included faster movement times , smaller dwell times , and more harmonic movements , all without decreases in movement accuracy.
These entropies were compared with the age and sleeping indices obtained with a conventional polysomnography ( PSG ) system.
These epidemiological findings suggest the possibility that both depression and dementia have common pathophysiological backgrounds of neuroinflammation.
These epigenetic alterations are heritable , potentially reversible , and seen as the epigenetic signature of carcinoma.
These epigenetic markers could provide important information in cases where the determination of a suspect's age is critical in developing investigative leads.
These epigenetic modifications may be used to track donor age for forensic analysis or to estimate biological age.
These epigenetic regulations are implicated in driving an imbalance between the expression of catabolic and anabolic factors , leading eventually to osteoarthritic cartilage destruction.
These epigenomic CGI clusters are strikingly distinct at multiple biological features including genomic , evolutionary , and functional characteristics.
These equivocal findings suggest that learning acquisition may be differentially affected by ethanol compared to memory , or that ethanol-induced cognitive deficits are task-dependent.
These ERP data indicate an age-related neural under-recruitment for proactive cognitive control and an age-related neural over-recruitment for reactive cognitive control.
These ER stress inducing factors include metabolic abnormalities , oxidative stress , viruses , and environmental exposures.
These estimates and observed baseline biomarker values were used as predictors of cognitive declines.
These estimates decreased slightly upon adjustment for road traffic noise.
These estimates decreased with increasing age , and there appeared to be no heritability of BMD changes after the age of @number@ years.
These estimates translate to an increased life expectancy of @number@ years at the age of @number@ years.
These ethical conundrums are not the focus of this article.
These etiologies are caused primary by cerebral emboli , hypoperfusion , or inflammation that has largely been attributed to the use of cardiopulmonary bypass.
These events also commonly occurred in both cell lines , suggesting that fucoidan triggered G1 arrest and apoptosis in HCT116 cells by a p53-independent mechanism.
These events lead to damage to proteins , lipids and mitochondrial DNA.
These everyday memory tasks measure genetically determined cognitive decline that can occur prior to a clinical diagnosis of dementia.
These examinations typically yield a large number of outcome variables , which may complicate the interpretation and communication of results.
These examples underscore the challenges ( perhaps impossibility ) of developing vitamin D guidelines using unstandardized 25 ( OH ) D data.
These executive functions are sensitive to the effects of aging and educational level.
These experiences include changes in identity and lifestyle that preclude a ' return to normal'.
These experiences may interact over time to sustain sharpened neural processing in central auditory nuclei well into older age.
These experts finally accepted a standard definition at an international consensus conference convened by the World Health Organization in @number@
These explanations were generally consistent with empirical evidence ; however , few articles included empirical evidence.
These exploratory and preliminary findings suggest that alterations in brain regions implicated in socioemotional functioning may be a marker of financial exploitation risk.
These facilities ' architectural design is considered to play an important role in realizing care visions.
These factors all are known to vary with tissue and animal ages , and health status.
These factors also contribute to the shortening of telomere length ( TL ) .
These factors are classified as social , psychological , and / or biological.
These factors are helpful for improving prognosis and increasing FAH.
These factors are key indicators of socio-ecological inequality.
These factors are likely to represent real determinants of aging-related muscle loss in men.
These factors can be altered by ageing , but it is not clear where these age-dependent factors are derived.
These factors can be used for prediction and prevention of delirium following cardiac surgery.
These factors describe a vulnerable population in need of protection and safety.
These factors further facilitated β-amyloid ( Aβ ) @number@ generation and ultimately modified patients ' susceptibility to AD.
These factors have implications for interventions designed to enhance coping strategies.
These factors have the potential to impact on the function of other vulnerable neurons within the central nervous system of older patients.
These factors include physical exercise , intellectual exercise , nutrition , sleep hygiene , social interaction , and mood and emotional state.
These factors include registered drugs and other chemicals , and account for diverse consequences which vary depending on the physiological condition.
These factors interact in increasing the likelihood of physical disease and of accelerated aging at the cellular level.
These factors lead to projected growth rates of near @number@ percent through @number@
These factors likely contribute to age-related reductions in mitochondrial function and lipid metabolism.
These factors may be considered as clinically significant parameters for defining the clinical evolution of CVD.
These factors may be helpful to determine a suitable timing for resumption of oral intake.
These factors may be particularly relevant to the relationship of developing dementia in the individual who has sustained a TBI earlier in life.
These factors may be substantially impacted by single or multi-domain strategies to prevent or postpone the onset of AD-related pathophysiology.
These factors must be considered in order to ensure the feasibility and applicability of future AMS interventions.
These factors need to be considered when integrating telomere measurement in biobehavioral research studies.
These factors negatively affect patients ' health-seeking behavior and thereby increase the risk of death.
These factors partially accounted for the association between early parenthood and onset of heart problems in later life.
These factors place great demands on healthcare systems and threaten sustainability.
These factors provide a potential basis for streamlining diagnostic evaluations and aiding in planning for effective therapy.
These factors reportedly exert distinct functions in membrane trafficking , as manifested by different phenotypes seen in single knockout mice.
These factors shape the labor market and working conditions for rural women.
These factors should be considered in research designs to enable comparison and validation of results.
These factors should be considered when developing interventions aimed at preventing and / or reducing the burden associated with frailty among community-dwelling older adults.
These factors should be emphasized in order to reduce fall injuries in geriatrics.
These factors should be taken into consideration when interpreting macular thickness measurements with SD-OCT.
These factors should thus be taken into account when developing interventions aimed at improving the QoL of the elderly in Lesotho.
These factors varied in their associations with grip strength across the adult lifespan.
These factors were able to explain @percent@.
These fast and slow adjustments presumably rely on different neural networks , with a possible role for subcortical pathways for the fast responses.
These features are then fed into a classifier for determination of age group.
These features consistently point towards selection against the malicious aggregation effects of elevated SOD1 levels in long-living great apes.
These features have been demonstrated in dozens of studies.
These features make the TD model amenable to investigate the cellular mechanisms of neurodegeneration.
These features were also associated with significantly reduced differentiation potential in aged MSCs compared to young MSCs.
These features were combined through a linear modeling to maximize the predictability of presence of stroke risk factors in the studied cohort.
These features were extracted from lumbar spine magnetic resonance images of @number@ subjects with age ranging from @number@ to @number@ years.
These few data indicate that sex differences in blood cell counts persist beyond @number@ years.
These figures are to be compared , respectively , with @percent@ and @percent@ among patients of European ethnicity.
These figures were more pronounced for tumor stages IIA and IIB.
These fillers appear at least as safe as temporary fillers in the short term in those studies that compared them.
These finding have implications for understanding the evolution of internal gestation in mammals.
These finding may inform the choice of functional runs when studying difficult-to-scan populations , such as children or certain patient populations.
These findings accentuate the need for age- and sex-matched control groups for the evaluation of cerebral pathologies such as hydrocephalus.
These findings add epidemiologic evidence in support of higher optimal protein intakes than the current guidelines for healthy older adults.
These findings add important new insights into the pathogenesis of obesity , T2D and HDL cholesterol.
These findings add to previous evidence of distinctions in the CNS control of volitional and perturbation-evoked arm movements.
These findings advance our understanding of the normal aging process.
These findings also highlight the association between attention and general fluid intelligence and how it may impact environmental awareness.
These findings also indicate that this age-related change can be prevented through participation in regular aerobic exercise.
These findings also suggest that APP transgenic mouse models may be useful in the search for new disease markers for AD.
These findings also suggest that sclera could be a useful target tissue for future patient-based , Raman spectroscopy studies.
These findings also support the MacArthur model of successful aging adapted to older adults with high levels of functional , social and cognitive ability.
These findings and the methodology applied may be relevant for the understanding and monitoring of rowing performance.
These findings anticipate an impact of TERRA-associated RBPs on telomere biology and telomeres diseases , such as cancer and aging.
These findings appear to create a new line of research regarding the biology of leadership and contextual cues of age.
These findings are applicable to the coordination training of patients.
These findings are a result of very high mortality rates observed after @number@ years of age.
These findings are ascribed to age-related changes of fiber type composition , fiber size and vascularity.
These findings are clinically significant , as previous studies associated these biomarkers with mortality.
These findings are considered in light of value-directed strategies when remembering social associative information.
These findings are considered in relation to the in-group / out-group model of social cognition and common stereotypical beliefs held about younger and older adults.
These findings are consistent with a mechanistic link between aging , α-synuclein abnormalities and enhanced vulnerability to neurodegenerative processes.
These findings are consistent with previous experimental results.
These findings are consistent with previous observations of age-related increases in goal shielding , but not with age-related deficits in task goal maintenance.
These findings are consistent with previous reports implicating lower glucocerebrosidase activity with PD risk.
These findings are consistent with the view that AD is not merely accelerated aging.
These findings are discussed regarding the transmission deficit hypothesis ( MacKay & Burke , @number@ ) .
These findings are discussed relative to evolving theory and research linking cognition and health.
These findings are discussed towards a possible occurrence of these reactions in cells.
These findings are discussed within the framework of current theories on the effects of error generation on episodic memory.
These findings are exciting and have important implications for the understanding of normal developmental and the evolutionary origin of senescence.
These findings are from the @number@ participants who reported to be @number@ years or older.
These findings are highly relevant for clinical practice and genetic counselling.
These findings are illustrated via presenting analysis of three commonly discussed activities : shopping , eating , and community mobility.
These findings are important because systolic hypotension may represent a potentially modifiable risk factor for LLD.
These findings are important for the development and use of GFR estimating equations based on low-molecular-weight serum proteins throughout the range in GFRs.
These findings are in agreement with the pathology literature , which suggests that tau tangles but not amyloid-β plaques correlate with cognition and clinical symptoms.
These findings are interesting from a health-promotion perspective , yet to verify these results , further longitudinal studies are required.
These findings are interpreted in terms of involvement of the hippocampus and frontal lobes in future thinking.
These findings are of importance for the individual prevention of LBP , and provide a baseline for differentiating symptomatic from asymptomatic age- and gender-matched subjects.
These findings are of particular interest , as the oldest age groups considered in these analyses did not include the baby boom population.
These findings are of particular relevance regarding implications for the understanding , treatment , and prevention of nonsuccessful aging like highly prevalent late-life depression.
These findings are of potential clinical relevance regarding the early detection of childhood psychopathology.
These findings are potentially relevant to the utilization of NMES for preparation of motor excitability.
These findings are relevant , since participation is an indicator for successful aging and has a positive influence on health and subjective well-being.
These findings are relevant to the research relating personality and anaclitic / introjective depressive experiences in late adulthood.
These findings are relevant to understanding the metabolic consequences of intermuscular adipogenesis.
These findings are supported by the increase in TFPI synthesized by VSMCs in response to cyclic stress in vitro.
These findings are the key for health care providers to improve the everyday care of this important group of frail older patients.
These findings are the same for males and females , for most muscles and muscle groups.
These findings are valuable to guide bone health interventions.
These findings at the whole-brain level are the widespread comprehensive neural network regions for guilty feelings.
These findings broaden observations that maternal obesity-related phenotypes have long-term consequences for offspring health.
These findings can add important information to the more accepted model in the literature that focuses mainly on early stages.
These findings can alert physicians to detect and intervene earlier on declining balance in older persons with DM.
These findings can assist in the prediction of the radiographic improvement of idiopathic planovalgus.
These findings can be a useful to generate other research hypothesis and for health professionals who care older persons.
These findings can be used to develop interventions incorporating an increased understanding of factors that are associated with both resilience and mastery.
These findings can help conceptualize depression and potentially reduce misdiagnosis for this age group.
These findings can help to determine an effective hypoxic exercise regimen to minimize immune dysfunction by retarding T-lymphocyte senescence.
These findings can inform the development and implementation of workplace health promotion programs that reflect the mental health needs of the aging workforce.
These findings can inform the development of measures to counteract the rise of obesity in China.
These findings can predict radiographic progression of scoliosis in CP patients.
These findings challenge the assumption that atherosclerosis is a modern disease caused by present day risk factors.
These findings confirm and extend prior studies.
These findings confirm a role of p62 / SQSTM1 as a cause of FTLD.
These findings confirm associations between both IR and DM on some neuropsychological tests and identify an interaction between HIV status and IR.
These findings confirm self-report evidence that personality traits are associated with physical activity levels in older adults.
These findings confirm the need for comprehensive evaluation of pain and related outcomes in all older adults , with appropriate pharmacologic and nonpharmacologic management.
These findings confirm the need to develop practical strategies and ways to address modifiable barriers and embed physical activity into LTC systems of care.
These findings contradict the notion of elevated CORT as a mediator of the accelerated aging observed in stress and depression.
These findings contribute new insights into the pathogenesis of obesity and triglycerides and demonstrate the importance of gender differences in the aetiology.
These findings contribute to our understanding of differences in pharyngeal strength , swallowing efficiency , and safety associated with aging.
These findings contribute to the understanding of the influence of maternal EC , directly and through caregiving , on toddler EC.
These findings correspond with studies suggesting increased health concerns in immigrants.
These findings corroborate and extend observations linking cognitive impairment and ambulation.
These findings could be essential to design gender-specific strategies in other in vivo experiments or even in AD treatments.
These findings could be used to target lung-cancer prevention measures to high-risk groups.
These findings could contribute to the development of improved gene therapies for various neurological disorders by exploring why microglia destroy viable cells following viral infection.
These findings could have important epidemiological significance and a direct influence on the remote plateau.
These findings could have profound implications for understanding the mechanism of mtDNA inheritance and the generation of mtDNA deletions in aging cells.
These findings could help prioritize preventive health programs offered by employers at their worksite health centers.
These findings could help to define biomarkers that can stage presymptomatic disease and track disease progression , which will be important for future therapeutic trials.
These findings could partly explain the effect of obesity on BE.
These findings coupled with a significant decrease in skin hydration , tonicity and elasticity and increased skin pH and sebum.
These findings created new therapeutic opportunities , like the use of losartan , known to have an antagonistic effect on TGF-beta.
These findings define a biochemical context for the physiological role of WRN in maintaining genetic stability.
These findings define a novel pathway that regulates senescent cell viability and fibrosis.
These findings define the deregulation of a UPR ( mt ) -mediated metabolic checkpoint as a reversible contributing factor for HSC aging.
These findings demonstrate age-related activation differences and differential effects of fatigue on activation in young and middle-aged adults.
These findings demonstrate an active involvement of CN- and NFAT-mediated signalling pathway in α-syn-mediated degeneration of mDA neurons in PD.
These findings demonstrate a pathogenic role of IL-21 in animal models of RA , suggesting IL-21 as a promising therapeutic target among human RA.
These findings demonstrated that reprogramming suppressed premature senescence phenotypes in WS cells and WS iPSCs could lead to chromosomal stability over the long term.
These findings demonstrate significant age effects on the CSF Aβ1-42 and pTau181 across lifespan.
These findings demonstrate that age of L2 acquisition is an important modulator of auditory responses in bilinguals even when processing non-speech signals.
These findings demonstrate that age-related changes in prefrontal recruitment and connectivity during retrieval depend on memory valence.
These findings demonstrate that COL17 governs IFE proliferation of neonatal and aged skin in distinct ways.
These findings demonstrate that GN activates the AMPK pathway and ameliorates HFD-induced hepatic steatosis.
These findings demonstrate that multiple germline variants predispose to MPN and link constitutional differences in MYB expression to disease phenotype.
These findings demonstrate that non homology-based processes contribute to the maintenance of t-circles and proliferation of ALT cells.
These findings demonstrate that OTUD3 is an essential regulator of PTEN and that the OTUD3-PTEN signalling axis plays a critical role in tumour suppression.
These findings demonstrate that the transcription of the IGFBP2 gene is modulated in a depot-specific fashion in obesity and aging in mice and men.
These findings demonstrate the need to take into account both sensory and cognitive demands of speech materials in older adults ' language comprehension.
These findings describe a minimally invasive , pharmacologically plausible strategy for treatment of HD and , potentially , other neuropathological diseases.
These findings do not explain the loss observed in in vivo survival studies with RBCs.
These findings do not support the concept that there may be a biological basis for dysfunctional labor or increased cesarean delivery rates in older parturients.
These findings do not support the hypothesis that stressful life events increase cortisol secretion leading to cognitive impairment.
These findings do not support the space anisometry interpretation of line bisection performance and the cross-over effect in patients with neglect.
These findings emphasize age-related changes in epileptic spasm pathophysiology or potentially evolution of disease with age.
These findings emphasize the emerging role of diffusion imaging in the differential diagnosis of neurodegenerative diseases.
These findings emphasize the importance of these relationships for the design and implementation of effective physical intervention for older adults.
These findings emphasize the need for different reference points for evaluation of submental MEPs of different age groups.
These findings emphasize the need for incorporating genetic perspectives into studies of human life-history evolution.
These findings emphasize the need to consider age-related changes in imagination and memory in a broader theoretical context.
These findings emphasize the need to discriminate between glycemic control and diabetic adjustment.
These findings expand the scope and delineate the conditions of novel association priming and inform theories about the nature of implicit memory for new associations.
These findings explain why surgical elevation of the mid and medial brow provides results that are neither youthful nor aesthetically pleasing.
These findings fit with the gendered life course perspective and cumulative disadvantage framework.
These findings for the first time implicate dysregulated IL-10 production in impaired vaccine responses in older adults.
These findings further clarify how SIRT6 promotes genome stability.
These findings further point to the wear-and-tear effect of long-term depression , but not PTSD , on telomere length.
These findings have been attributed to error , rather than actual telomere elongation , restricting our understanding of its possible biological significance.
These findings have been further validated by fluorochrome tracer studies.
These findings have been interpreted as part of a glutamate-mediated compensatory effect in response to vascular lesions.
These findings have been replicated in several randomized , clinical trials.
These findings have direct implications for proliferative tissue homeostasis as well as for cellular and organismal aging.
These findings have implications for clinical care and public policy.
These findings have implications for daily and work-related tasks that involve cognitive demand performed simultaneously during submaximal isometric contractions in an aging workforce.
These findings have implications for developing strategies aimed at increasing MPC migration and proliferation leading to an improved regenerative capacity of aged skeletal muscle.
These findings have implications for making more evidence-based recommendations about the capacity for independent living.
These findings have implications for psychiatric disorders , such as post-traumatic stress disorder , which are characterized by aberrant limbic connectivity.
These findings have implications for public health initiatives for stroke.
These findings have implications for public health policy implementation in an aging population.
These findings have implications for social and public health surveillance and intervention to address the harmful consequences of discrimination.
These findings have implications for the development of selective ligands for symptomatic therapy in AD and for its diagnosis.
These findings have implications for the development of therapeutic interventions for neural tumors and neurodegenerative conditions.
These findings have implications for the monitoring of suicide risk when aiming to enhance mental health and well-being and prevent suicide in later life.
These findings have implications for the success of therapeutic strategies for the treatment of AD that rely upon the health of the ageing cerebral vasculature.
These findings have implications for treating specific diseases , including neurodegeneration and cancer , as well as targeting aging in general.
These findings have implications for workforce planning and the quality of care provision in nursing homes.
These findings have implications in the etiology of schizophrenia , and for the clinical management of these patients.
These findings have important clinical implications for the management of uncorrected hyperopia.
These findings have important implications for promoting successful aging in China.
These findings have important implications for service providers , researchers , and policymakers.
These findings have important implications for the treatment of T1D.
These findings have important implications for understanding the relationships between aging , executive control , and strategy execution in episodic memory.
These findings have important implications regarding mechanisms underlying strategy execution and aging effects on strategic variations.
These findings have opened up a new field in glycoscience.
These findings have opened up new avenues to explore the therapeutic application of ECs.
These findings have potential clinical relevance for screening and early detection of individuals at risk.
These findings have potential implications for the treatment of late-life depression and for the prognosis of cognitive outcomes.
These findings have relevance for understanding age-related differences in memory and affect regulation.
These findings have shed some light onto the putative molecular mechanisms by which alterations in A-type lamins induce genomic instability and contribute to disease.
These findings have significant implications for care delivery and future program planning in caring for residents with special needs.
These findings have significant implications for our understanding of the pathobiology of age-associated diseases and may guide targeted immunotherapy.
These findings have sometimes led to inferences that the age-related brain changes cause the age-related cognitive changes.
These findings have stimulated interest in the underlying biological processes that might impart to humans an inherent predisposition to the development of atherosclerosis.
These findings have unveiled an unexpected link between aging and phosphate.
These findings held after we controlled for educational attainment and other demographic factors.
These findings help establish the functional basis of BOLD variability , and further support the statistical and spatial differentiation between BOLD variability and BOLD mean.
These findings highlight important pathological relationships linking a compromise in protein turnover with the histone changes observed in Alzheimer's disease post-mortem human brain.
These findings highlight observer perceptions of face-lift surgery that could positively influence social interactions.
These findings highlight that in cognitively intact older adults , the association between anxiety and worse cognitive performance is bidirectional and complex.
These findings highlight the contribution of vascular determinants in cognitive decline even in this very old population.
These findings highlight the differences in the speed effects on muscle co-contraction of the ankle joint during dynamic postural control between the two age groups.
These findings highlight the impact that sleep disturbances can have on people living with dementia.
These findings highlight the importance for cognitive training of top-down control of sensory processing by the dorsal attention network.
These findings highlight the importance of balance assessment in older patients at all COPD grades.
These findings highlight the importance of considering non-GFR determinants of kidney function.
These findings highlight the importance of CRF in mediating BMI-associated HF risk.
These findings highlight the importance of engaging older adults to repurpose their life skills and thus reapply wisdom to new areas of their lives.
These findings highlight the importance of favourable working conditions and good physical health in relation to employees ' intention to continue working after @number@ years.
These findings highlight the importance of life-course perspective when assessing the association between BMI and cognition.
These findings highlight the importance of studying functionally relevant behavior such as speech to understand the mechanisms of human brain aging.
These findings highlight the importance of studying language acquisition at close time intervals over a substantial age range.
These findings highlight the large burden of disease from DENV and the need for enhanced arbovirus surveillance and implementation of vector control strategies throughout Haiti.
These findings highlight the need for further health sector shifts to address the double burden of infectious and NCDs , particularly in the ageing population.
These findings highlight the need for further observational , interventional , and experimental studies of the effects TFA on DM.
These findings highlight the need for more research documenting the effects of age-friendly environments , particularly across diverse contexts and populations.
These findings highlight the potential benefits from public health interventions to increase the use of screening colonoscopy.
These findings highlight the relationship between housing status , dignity , and shifting identities as older adults experience the aging process in a low-income context.
These findings highlight the value of a simultaneous assessment of important prognostic disease characteristics within a single measurement.
These findings highlight this mode of exercise as an important component of public health promotion programs for aged women.
These findings identify a premature T-cell senescence in ICL that might be caused by chronic T-cell activation and a consequential DUSP4-dependent dampening of TCR signaling.
These findings identify lipid-derived free radical species as possible contributors to peripheral mononuclear cell DNA damage in the human exercising model.
These findings identify potential targets for immunomodulation and treatment to combat lethal WNV infection in the elderly.
These findings identify spindle-associated RHAMM as an intrinsic regulator of male germ cell fate and as a gatekeeper preventing initiation of TGCTs.
These findings , if confirmed by others , suggest a potential role for vitamin D in maintaining healthy sleep.
These findings , if confirmed in prospective studies , may provide insights into new pathogenic pathways and possibly therapeutic targets in AMD.
These findings illustrate potential mechanisms underlying osteoporotic proximal tibial fracture.
These findings illustrate that faces can activate certain social categories and preconceived stereotypes that then influence vocal and person perception in a corresponding fashion.
These findings illustrate that older Mexican Americans in the United States are heterogeneous in nativity and health outcomes.
These findings illustrate the complex interplay between personality characteristics , depressive symptoms and different indices of the cortisol diurnal rhythm.
These findings illustrate the importance of considering the prevalence of low scores in healthy individuals.
These findings implicate activated human macrophages , particularly M ( IFNγ and LPS ) macrophages from nvAMD patients , in nvAMD.
These findings implicate age-related declines in callosal size and integrity as a key contributor to bimanual control deficits.
These findings implicate altered ribosomal protein expression in sgf73Δ yeast RLS and highlight altered acetylation as a pathway of relevance for SCA7 neurodegeneration.
These findings implicate neurobiological processes early in the pathogenesis of falls.
These findings implicate that PICALM might not play a major role in the genetic predisposition to LOAD in Han Chinese.
These findings imply accelerated organismal aging.
These findings imply a strong interconnection between physical and mental health , where the greatest disablement occurs when both somatic and mental disorders are present.
These findings imply that unfavorable lipid profile may be involved in late-life depressive symptoms independent of atherosclerotic disorders.
These findings increase our understanding of how the metabolic impact of HIV is influenced by age.
These findings indicate a connection between miR-181 and proteins involve in synaptic plasticity and memory processing in a transgenic mouse model of AD.
These findings indicate a preserved capacity of the aging human hippocampus for functionally relevant vascular plasticity , which decreases with progressing age.
These findings indicate a yet unexplained shift from pro-inflammatory Th1 cell response to an anti-inflammatory Th2 response with aging.
These findings indicate considerable differences in the genetic variations associated with familial ALS across populations.
These findings indicate different factors contributing to caregivers ' use of different coping styles and suggest ways to better help caregivers.
These findings indicated that changes in lens may serve as markers for ageing and systemic health in general population.
These findings indicated that such activities may have had a positive influence on the informants ' health and well-being.
These findings indicate that 25 ( OH ) D level in postmenopausal women from Tehran is low.
These findings indicate that AAV-mediated cardiac transduction with microdystrophin might be a promising therapeutic strategy for the treatment of dystrophin-deficient cardiomyopathy.
These findings indicate that adult craniofacial curvature shape is not static throughout human life.
These findings indicate that age-related associative memory deficits may stem at least in part from age differences in use of stimulus characteristics for contextual support.
These findings indicate that aging differentially affects naive and memory Th17 cell responses in humans.
These findings indicate that along with adiposity , muscle mass is an independent determinant of plasma BNP.
These findings indicate that although aging and CR in mice are both associated with hippocampal volume reductions , the patterns of the volume reductions differ.
These findings indicate that androgen plays an important role in mitochondrial gene expression in the hippocampus.
These findings indicate that anti-CMV IgG serology is neither sensitive to change nor useful for monitoring chronic CMV infection over time.
These findings indicate that a stimulatory effect on plasma cell differentiation could occur in untreated patients with Graves ' disease.
These findings indicate that behavioral interventions can greatly improve visual performance for older adults.
These findings indicate that brain region-specific altered monoamines and metabolites may contribute to the occurrence of depression and aggression in AD.
These findings indicate that chronic diseases may occur independently of aging and may have a programmed onset pattern.
These findings indicate that cohesin is a key molecular link between female aging and chromosome missegregation during MI.
These findings indicate that contrast-sensitivity deficit is a major limiting factor of object recognition for individuals with AMD , in addition to crowding.
These findings indicate that dysfunctional regret regulation plays an important role for sleep disturbances in elderly people.
These findings indicate that encoding impairment with age may be associated with dysfunctional Gamma oscillatory activity across a widespread network of left cortical regions.
These findings indicate that it is necessary to establish an outcomes-based and ethnic-specific set of reference values for the diagnosis of sarcopenia in elderly Chinese.
These findings indicate that KOR agonists play an important role in tumor angiogenesis and this knowledge could lead to a novel strategy for cancer therapy.
These findings indicate that low mood is particularly prominent in the very early stages of cognitive decline.
These findings indicate that LTCI services usable for dialysis patients were limited.
These findings indicate that many women may habitually strain to void as well as strain due to inadequate detrusor function.
These findings indicate that muscle weakness in old age stems in part from an impaired capacity for force production in the individual muscle fibres.
These findings indicate that other sirtuins with weak deacetylase activity may also possess novel activities on unknown protein posttranslational modifications.
These findings indicate that p190 is a possible molecular target for treatment of lung adenocarcinoma.
These findings indicate that parent-child interactions affect the right STG , which may be associated with verbal skills.
These findings indicate that prediction of activity types for data collected during natural activities of daily living may actually be possible.
These findings indicate that prohibitin is a context-dependent modulator of longevity.
These findings indicate that PYP1-5 activates the TGF-β / Smad signaling pathway , which subsequently induces collagen synthesis in Hs27 cells.
These findings indicate that removal of extracellular Aβ-O can fully or partially reverse Aβ-O-induced neurotoxic alterations in our neuron model.
These findings indicate that rTMS at 10-Hz accelerated the onset of action and augmented the response to paroxetine for first-episode depressed patients.
These findings indicate that SSTIs present various opportunities to improve antibiotic stewardship.
These findings indicate that synapse loss is probably not a hallmark specific to AD but rather a change common to many diseases associated with dementia.
These findings indicate that the age-associated impairments in movement control are associated with altered activation of the involved antagonistic muscles.
These findings indicate that the causes and consequences of change in BMI differ across the lifespan.
These findings indicate that the evolution of human longevity was likely independent of CR-induced lifespan extension mechanisms.
These findings indicate that therapies that enhance the function of alveolar macrophages may improve outcomes in older people infected with respiratory viruses.
These findings indicate that the SM theory needs to be generalized to incorporate heterogeneity among human populations.
These findings indicate that valve tissue biomechanical properties vary in wild type mice in a region-specific and age-related manner.
These findings indicate the drug as a possible treatment for Mandibuloacral dysplasia.
These findings indicate the importance of age as a factor when designing cell-based therapies for older patients.
These findings indicate the importance of consideration of management issues in achieving stable financial performance in home-visit nursing agencies in Japan.
These findings indicate WMSA is an important pathological component of AD development.
These findings inform our knowledge of the evolutionary changes responsible for the special features of the modern human mind.
These findings inform strategies to maintain participation in life course studies.
These findings inform understandings of services for people aging with HIV who may experience mental health concerns.
These findings in health professionals need to be replicated in the general populations.
These findings justify further investigation regarding the modulatory role by caveolin on synaptic function and as a potential therapeutic target for the treatment of schizophrenia.
These findings lay new grounds for understanding the increased cardiovascular risk in individuals born prematurely and open perspectives for therapeutic strategy.
These findings led us to the conclusion that stress hyperglycemia is occasionally seen in critically ill patients.
These findings lend additional support to the NYUCI as an evidence-based approach to support family caregivers of persons with dementia.
These findings may add to current knowledge for the regulatory mechanisms of Ca ( 2 + ) and calpain.
These findings may be helpful to adapt treatment to individual patient needs.
These findings may be of greater clinical relevance when offered in conjunction with other therapies.
These findings may be of value in blepharoplasty and midfacial rejuvenation.
These findings may be the neural underpinnings for the progressive maturation of motivational control over risk taking behaviours between adolescence and adulthood.
These findings may be useful for clinicians when assessing depression in older adults and for researchers when exploring and comparing depression prevalence across studies.
These findings may contribute to a better understanding of olfaction and specific cognitive domains known to be affected by aging and implicated in neurodegenerative disease.
These findings may contribute to the development of therapies for the liver disorders and HCC associated with pre-S2 deletion mutations among HBV carriers.
These findings may contribute to understanding how APOE4 genotypes affect AD risk.
These findings may enable development of novel strategies to restore the function of senescent cardiovascular and other SMC-containing tissues.
These findings may enable improved gait monitoring and efforts in falls prevention.
These findings may further our understanding of ovarian aging , and be useful when counseling BMCs.
These findings may guide the development of future weight management interventions in a congregate meal setting.
These findings may have implications for early diagnosis , prognosis , and clinical management.
These findings may have significant implications regarding surgical maneuvers influencing tip projection , effects of aging on the nose , and columellar aesthetics and function.
These findings may have therapeutic implications for the clinical use of HDAC inhibitors in psychiatric disorders.
These findings may help counsel patients regarding the risks of weight gain.
These findings may help further our understanding of the pathophysiology of MTS.
These findings may help refine the definition of optimal ranges of thyroid function tests.
These findings may help to explain poor prognosis with advancing age following repair.
These findings may indicate a more conscious locomotor and postural strategy in the elderly.
These findings may indicate involvement of the immune system in Alzheimer's disease pathogenesis.
These findings may inform both pre-hospital and subsequent emergency department ( ED ) based decisions.
These findings may inform current theories of memory decline such as those linked to cognitive aging.
These findings may prove helpful in understanding the mental processes involved in purchase decisions.
These findings may provide a framework to support clinical studies , although further basic research is needed.
These findings may provide a framework to understand the actual disease burden and establish the optimal management strategy for AF.
These findings may provide information on distinct mechanisms of inter-individual cortical variation as well as factors contributing to trajectories of cortical thinning with advancing age.
These findings may provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.
These findings may provide the basis for new indications for ticagrelor.
These findings may represent a critical roadmap for therapeutic intervention and prevention of KS-related testis failure.
These findings may suggest a possible role for cg07955995 and cg22285878 in immunosenescence.
These findings may translate into novel treatments to ameliorate cognitive decline in normal aging in the future.
These findings might be consistent with the increase in life expectancy and life span in good health.
These findings might explain the greater lifetime tendency to develop malignancies and diseases related to early aging in these individuals.
These findings might have implications for targeted therapeutic interventions in elderly patients.
These findings might help elucidate the neural mechanisms associated with sexual dysfunction in menopausal women.
These findings motivate a nuanced theory of maturation and age-related decline , in which multiple , dissociable factors differentially affect different domains of cognition.
These findings need consideration in case of life-threatening neurosurgical emergencies as well as in the surgical treatment of elderly patients in general.
These findings need more validation by larger studies.
These findings occur in both data sets , and for both men and women.
These findings occurred across both age groups and persevered when holding constant the sample normalization process.
These findings occurred in concomitance with increased levels of phosphorylated XRCC1 detected in DS cells.
These findings offer a starting point for the development of a solid neuropsychological and neuroanatomical account for the person-centered approach.
These findings of molecular heterogeneity and proliferative differences subdivide the NSC population and have implications for neurogenesis in the forebrain of mammals during aging.
These findings open new avenues for the specific prevention or treatment of nonvertebral fractures , a substantial unmet medical need.
These findings paint a clear picture of older Internet daters as eager to meet the right person , but not desperate to meet just anyone.
These findings place SIRT7 at the crossroads of chromatin signaling , metabolic , and tumor-regulatory pathways.
These findings point to agerelated differences in thrombelastographic parameters.
These findings point to similarities in the neural substrates of verbal and non-verbal rehearsal processes.
These findings point to the need for more attention on nutritional assessment , interventions , and services for community-dwelling older adults.
These findings point toward a novel acetylation-dependent polysome assembly mechanism regulating tumorigenesis.
These findings prompted studies on the neural consequences of long-term E2 deprivation in postmenopausal women.
These findings provide additional evidence that mosaic genomic heterogeneity may play a key role in AD pathology.
These findings provide additional support for a relevant role of vascular system since its earliest stage in frailty.
These findings provide a framework for the development of interventions to prevent the emergence of clinically significant depressive symptoms in the elderly.
These findings provide a mechanistic account for the construction of food value from its constituent nutrients.
These findings provide a more comprehensive theoretical basis for the use of Dendrobium for the treatment of diabetic cataract.
These findings provide an important example of a form of associative processing that is unimpaired in older adults.
These findings provide a useful resource to further biological exploration of the functions of protein synthesis in regulation of proteostasis and stress responses.
These findings provided empirical evidence for the development of EF structure which progressed from unity to diversity during middle childhood and adolescence.
These findings provide direct insights into how nature reversibly adjusts lifespan and other traits during adaptive radiation of lineages.
These findings provide evidence against the reverse causality hypothesis and strengthen evidence for personality traits as a risk factor for dementia.
These findings provide evidence for a potential therapeutic use of chronic lower limb heating to improve vascular health in primary aging and various disease conditions.
These findings provide evidence for a previously unknown mechanism by which mitochondria regulate the inverse correlation between osteoclast survival and bone resorption.
These findings provide evidence for discrimination- and attention-based accounts of the spacing effect in natural concept learning.
These findings provide evidence that \ "functional anatomy \ " which supports normal memory performance changes across the life span.
These findings provide evidence that regional loss of nigrostriatal inputs to frontostriatal networks affects specific aspects of motor function.
These findings provide further evidence for an association of NOS1 with AD.
These findings provide further evidence that the anatomical distribution of MRI-visible perivascular spaces may reflect the underlying cerebral small vessel disease.
These findings provide further insights into the pathophysiological mechanisms linking low testosterone and SHBG concentrations to cardiometabolic risk.
These findings provide further support for a previously proposed role for the GRN gene in the genetic etiology of FTD and its phenotypic variability.
These findings provide further understanding of the underlying mechanisms of age-related slowing of human motor performance.
These findings provide important basic information for all parties involved in Japanese frailty research.
These findings provide important implications for both research and clinical applications of the MAT in older populations.
These findings provide important insights into the biological functions of SIRT7 , as well as an improved platform to develop SIRT7 modulators.
These findings provide insights into the role of TREM2 in AD pathogenesis , and highlight TREM2 as a potential therapeutic target for this disease.
These findings provide mechanistic insight into the neuroprotective role of SNO-DJ-1 by elucidating how DJ-1 detoxifies NO via transnitrosylation to PTEN.
These findings provide new data for Persian-speaking children , women , and men and could be beneficial for Iranian speech and language pathologists.
These findings provide new insights into the beneficial role of mussel bioactive peptides on retarding senescence process.
These findings provide novel insight into the molecular mechanisms underlying brain aging and a resource for future studies on age-related brain disorders.
These findings provide preliminary support that higher fruit and vegetable intake and exercise improve survival.
These findings provide scientific evidence to explain the efficacy of Kangen-karyu based on its underlying therapeutic effects.
These findings provide support for the notion that D1 receptors in separate brain regions are differentially related to performance in tasks tapping various cognitive domains.
These findings provide support for the reserve hypothesis and highlight the need to consider individual differences when studying cognitive and cerebral changes in aging.
These findings provide supportive evidence to explore new ideas of the pathogenesis of vitiligo and other pigmentation disorders.
These findings provide the evidence that missense variants in the CR1 gene may be involved in LOAD pathologic process in Han Chinese.
These findings provide the strongest evidence to date that advanced paternal age is a risk factor for autism in the offspring.
These findings provide widespread evidence across Europe that social limits exist alongside biological ones , though both sets of factors are more binding for women.
These findings quantitatively characterize the amplitude- and frequency-dependent nature of young healthy tracking and balance in this task.
These findings raise the possibility of using the complexity of physiologic signals as the basis of novel dynamical biomarkers of depression.
These findings recapitulate the changes reported in mice with induced neuron-specific autophagy defects.
These findings reconcile some previously inconsistent findings , provide other new findings and suggest that these areas contribute to empathizing-systemizing.
These findings reflect and support the viability of progression in resistance exercise dosage to accommodate optimal muscular adaptive response.
These findings reflect socioeconomic disparities in chemotherapy use for melanoma among older white patients in the United States.
These findings regarding dopamine transmission efficacy may be explained by a hypothetical inverted U-shaped curve.
These findings reinforce the hypothesized discussion regarding pathways from social capital to psychological distress via supportive relationships.
These findings reinforce the idea that low testosterone levels pretreatment are related to a poor prognosis in PCa.
These findings reinforce the importance of screening for these frequently coincident conditions.
These findings reinforce the need for participants of aged care homes to receive periodic medication review aimed at minimizing morbidity associated with inappropriate pharmacotherapy.
These findings remained after adjusting for age , sex and 5-year weight change.
These findings remained largely unchanged after controlling for intelligence quotient and after accounting for psychotropic medication usage and comorbid psychopathology.
These findings remain unchanged among pediatric patients aged ≥14 years ; however , no gender differences were noted in individuals aged ≤13 years.
These findings replicated for CTLA4 and HLA-DQA1 in an independent cohort of Italian cases and control individuals.
These findings represent a paradigm shift in our concepts of mt-nuclear interactions.
These findings represent systematic , large-scale mechanisms of early AD pathology.
These findings require confirmation in prospective studies.
These findings require replication in studies with more accurate dating of the onset of diabetes.
These findings results were consistent with those obtained from the pilot testing.
These findings reveal age-related changes of limbic system in normal population that may contribute to future DTI studies.
These findings reveal an evolutionarily conserved positive feedback mechanism underlying robustness of the Hippo pathway in size control and tumorigenesis.
These findings reveal a novel aging cascade whereby resistance to collagen cleavage accelerates cellular aging.
These findings reveal an unexpected role of TRF2 in neoangiogenesis and delineate a distinct function of TRF2 as a transcriptional regulator.
These findings reveal a role for RB1 in the ENS.
These findings revealed a clear dissociation between explicit and implicit memory tasks in normal and pathological aging.
These findings reveal fundamental insights into brain network dynamics in aging and the capacity to probe them with combined behavioral and stimulation approaches.
These findings reveal phospho / sphingolipids as putative markers and biological modulators of healthy aging , in humans.
These findings reveal that the tumor suppressor HACE1 plays a role in the NRF2 antioxidative stress response pathway and in neurodegeneration.
These findings reveal the importance of the early origins of AMI and health behaviors as mediating factors.
These findings set the stage for studying developmental change in the perspective of multiple predictors , rather than solely by divisions based on age groups.
These findings shed light on the \ "frontal hypothesis of aging. \ "
These findings shed new light on the mechanisms of skin aging and identify future opportunities for its therapeutic prevention.
These findings should be considered in clinical practice and when designing disc prostheses.
These findings should be considered preliminary until confirmed by a prospective cohort study.
These findings should be considered when supporting the elderly in successful aging.
These findings should be further explored in studies on the role of GR in PCOS-related metabolic derangements.
These findings should be taken into account when allocating resources that will optimize outcomes for this growing population.
These findings should be taken into consideration when deciding on the treatment strategy for elderly ACS patients undergoing PCI.
These findings should be valuable for the development of cosmetic or medical treatments to prevent unfavorable skin deformations.
These findings should help in the development of FK228 analogs as novel HDAC / PI3K dual inhibitors.
These findings should provide guidance on the time course of myopia and on decisions regarding the type and timing of interventions.
These findings should provide unique insights into preventative and / or therapeutic approaches to control neurotoxic Aβ levels in the aging brain.
These findings showed older adults ' impaired ability to use controlled retrieval to avoid proactive and retroactive interference.
These findings showed that a preceding balance task increased the task demand and required modifications in the movement strategy.
These findings show that age-related changes in amyloid characteristics may be a trigger for late-onset polyglutamine diseases.
These findings show that both right hemispheric and dorsal retinotopic patterns of dominance in low-level vision emerge early in childhood , maintaining during aging.
These findings show that memories undergo qualitative changes as they age.
These findings show that normal aging mostly affects interactions in beta band , which are probably involved in attentional processes.
These findings show that poor maternal nutrition can prime a prediabetes phenotype , often manifest as insulin resistance , by very early stages of life.
These findings show that such basic autism-associated deficits persist until adulthood , although patients are able to learn social rules.
These findings show that the immunodeficiency in A-T patients may be described as congenitally aged and is not progressive.
These findings speak for multidirectional and context-dependent age differences in empathy.
These findings strengthen our understanding of the clinical heterogeneity of PD , and may have implications for molecular classification of the disease.
These findings strongly suggest a link between mastication and neurocognitive function.
These findings strongly suggest that HSF elastase is identical to NEP , which functions mainly in neuron-associated cells to degrade neuropeptides.
These findings strongly suggest that screening of non-communicable diseases should be integrated into routine HIV care in Cambodia.
These findings strongly suggest that T therapy in hypogonadal men may prove useful in reducing the risk of cardiometabolic diseases.
These findings suggest a central role of the insular cortex in the transition from mere detection of chemosensory convergence to a superadditive flavor representation.
These findings suggest a cortical component to sensory re-weighting that is more distributed and requires greater attention in older adults.
These findings suggest a decreased ability of the R group to downmodulate immune activation compared to the NR group.
These findings suggest a gradual change in membrane lipid composition over the adult life span.
These findings suggest a need to customize the management of individuals hospitalized with CHF or COPD based on baseline life-space level.
These findings suggest a need to improve the treatment of UI in individuals with impaired cognition.
These findings suggest a need to increase activity among middle-aged and older adults , particularly those with SCD who receive care.
These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease.
These findings suggest an important role by which neuron-targeted Cav-1 regulates DISC1 neurobiology with implications for synaptic plasticity.
These findings suggest a novel function of the pch-2 gene involved in lifespan determination.
These findings suggest a novel pathway whereby p53 and RAD9 control the DDR through a shared mechanism involving an overlapping network of downstream target genes.
These findings suggest an unexpected interpretation of the effects of altered proteostasis on survival.
These findings suggest a possible role of sex hormones in modulating the cortisol stress response function in emotion regulation.
These findings suggest a role for hypertensive vasculopathy and the combined effect of hypertensive and cerebral amyloid angiopathy in the pathogenesis of cognitive deterioration.
These findings suggest a role for magnesium supplementation in preventing or delaying the age-related decline in physical performance.
These findings suggest a role of breastfeeding in determining lower body explosive strength during adolescence.
These findings suggest a secular increase trend in serum arachidonic acid levels over @number@ years among randomly selected community-dwelling middle-aged and elderly Japanese.
These findings suggest a tentative role for fibrinogen as a determinant of late-life cognitive performance and justify further attempts at replication in older persons.
These findings suggest a therapeutic potential for Cbln4 in the treatment of AD.
These findings suggest common mechanisms in the development of both CKD and aging.
These findings suggest deterioration in muscle function with age in a sample of healthy adults presenting with functional swallowing.
These findings suggest dietary ALA may reduce hip fracture risk in women and men and dietary AA may reduce hip fracture risk in men.
These findings suggested that a higher ACCI score was an independent predictor of the development of prolonged POI.
These findings suggested that Asian older adults may be protected from the clinical manifestation of brain TDP-43 proteinopathy.
These findings suggested that a startle reflex contributes to the exaggerated postural FTR observed during externally-triggered whole-body free falls.
These findings suggested that F2RL3 methylation is a very strong predictor of lung cancer risk and mortality , particularly at older age.
These findings suggested that less reduction in lens power might be associated with both growing age and increasing AL in myopes.
These findings suggested that the pro-aging impact of proteasome upregulation might be related to changes in the metabolic state through a premature induction of respiration.
These findings suggested that USP14 induces NF-κB activity and ERK1 / 2 phosphorylation triggered by microbial infection.
These findings suggest higher environmental UV exposure resulted in higher levels of CD in the skin of German women compared with Japanese women.
These findings suggest hippocampal atrophy in Alzheimer's disease may be more focal than in VaD.
These findings suggest home-based step training systems present low risk of harm through negative transfer effects in untrained stepping directions.
These findings suggest important possibilities in terms of preventing and better treating RHTN.
These findings suggest increasing CGG repeat and FMR1 mRNA levels have neurotoxic effects on cerebellar regions underlying anticipatory postural responses during stepping.
These findings suggest Neuropep- @date@ be a therapeutic candidate for the treatment of AD.
These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival.
These findings suggest some flexibility in gender systems with respect to intergenerational support within Barbado.
These findings suggest testosterone replacement therapy may be considered in men with a history of prostate cancer , but confirmatory prospective studies are needed.
These findings suggest that ability to extract global contours embedded in clutter declines in older age.
These findings suggest that acidified bile acids play an important role in the malignant progression of local recurrent gastric cancer.
These findings suggest that ACPs differ for cognitively impaired persons , indicating a need for further investigation.
These findings suggest that affective experience is a function of individual differences and the type of social partners oldest-old adults interact with in everyday life.
These findings suggest that age- and gender-associated differences in muscle condition are detectable using EIM.
These findings suggest that age-related differences in CDA reflect changes in the top-down control over WM representations.
These findings suggest that airway responsiveness in COPD and asthma is determined by underlying disease-specific processes , rather than a common pattern of physiological abnormality.
These findings suggest that a low-fat diet may promote weight gain , whereas a reduced-carbohydrate diet may decrease risk of postmenopausal weight gain.
These findings suggest that a multimodal intervention is effective in improving cognitive functions and well-being and can induce functional changes in the aging brain.
These findings suggest that an even greater effort at patient education is needed prior to elective PCI to facilitate fully informed decision-making.
These findings suggest that a new approach is required to target multimorbidity in octogenarians.
These findings suggest that anxiety could be linked to cardiovascular aging as it attenuates cardiac reactivity and exaggerates vascular responses to stress.
These findings suggest that ApoE4 may increase susceptibility to molecular pathology and modulate the anatomic pattern of neurodegeneration in AD.
These findings suggest that a progressive increase of cortical hyperexcitability causes exaggeration of cortical tremor.
These findings suggest that attentional focus affects children and adults similarly , but task complexity and sex moderate these effects.
These findings suggest that attenuated cardiovascular adjustments to heat stress in healthy aged individuals are unlikely to be related to attenuated increases in sympathetic activity.
These findings suggest that atypical antipsychotics that cause high-risk for MetS , particularly olanzapine , may modulate leukocyte TL in SZ patients.
These findings suggest that better retention of memory cells specific for previously encountered antigens may provide a survival advantage in this particular population.
These findings suggest that birth order and family dynamics can have profound effects on surrogate stress and coping.
These findings suggest that brain structure in presenilin @number@ mutation carriers follows nonlinear trajectories , with regional increases during the very early presymptomatic period.
These findings suggest that C9orf72-specific phenomena may impact brain structure and function and emerge before first symptoms and TDP-43 aggregation.
These findings suggest that clinicians should educate FCGs about self-care and offer strategies for dealing with a cluster of symptoms when maintaining sleep hygiene.
These findings suggest that cortisol may not play an important role in cognitive aging across the life course.
These findings suggest that cranberry promotes healthy aging by increasing stress responsiveness.
These findings suggest that dance training was effective to change the lower limb muscle architecture in older female adults.
These findings suggest that DDR intervention is as effective as that of brisk walking in improving inhibitory control for elderly people.
These findings suggest that decreased PS appears to underlie post-stroke cognitive dysfunction and may serve as a potential target for intervention.
These findings suggest that diffusion tensor imaging and resting-state fMRI may have the potential to become sensitive biomarkers for early FTD in future clinical trials.
These findings suggest that diminished hemispheric lateralization , which accompanies aging , may affect the perception of the 3D structure of shaded surfaces.
These findings suggest that dose selection is an important variable when considering the use of VEGF-targeting agents for the treatment of ROP.
These findings suggest that dysfunction in the medial temporal lobe may represent a very early sign of preclinical AD and may predict future memory loss.
These findings suggest that efforts to ameliorate depressive symptoms may be as important as treating CVD severity to enhance functional status.
These findings suggest that elevating plasma apoA-I / HDL levels may be an effective approach to preserve cognitive function in patients with AD.
These findings suggest that even during slow-speed walking , leg BFR induces substantial hypertensive responses in the aorta.
These findings suggest that even low-dose-radiation exposure can accelerate thymic aging , with decreased thymopoiesis relative to nonexposed controls evident years after exposure.
These findings suggest that facial rejuvenation surgery conveys an even larger societal benefit than merely restoring a youthful appearance to the face.
These findings suggest that factors besides chronological age mediate exercising leg hemodynamics in middle-aged to older adults and that these factors are sex-specific.
These findings suggest that frail elderly women present an autonomic imbalance characterized by a shift towards sympathetic predominance.
These findings suggest that FTLD-TDP and ALS are at two ends of the same disease spectrum , i. e. , TDP-43 proteinopathy.
These findings suggest that genetic fitness , as currently defined , is not the sole factor enabling an increased life span.
These findings suggest that healthy girls and boys show a difference in the correlation between parental reports of emotional control and the left amygdala volume.
These findings suggest that high IL-6 and CRP levels may be an indication of prevalent impaired pulmonary function.
These findings suggest that improvement in memory in midlife is associated with sparing of hippocampal volume in later life.
These findings suggest that increased acculturation may provide Mexican Americans with protection from health issues in old age.
These findings suggest that increased AL in older age is only associated with depressive symptomatology acutely.
These findings suggest that increased cognitive dispersion is related to NFT pathology where age significantly affects this association.
These findings suggest that increased physical activity may have a role in decreasing aging-related losses of interhemispheric inhibition.
These findings suggest that , in general , YM demonstrate greater adaptability within the endocrine system compared with OM.
These findings suggest that interaction of the individual components of metabolic syndrome plays a role in the relationship between metabolic syndrome and arterial stiffness.
These findings suggest that interventions aimed at reducing BP variability will need to consider large artery stiffness for optimal efficacy.
These findings suggest that interventions to mitigate anxiety symptoms may help delay memory decline in otherwise healthy older adults with elevated beta-amyloid.
These findings suggest that late but not early onset of OCD is associated with abnormally low SERT availability.
These findings suggest that light to moderate alcohol consumption is potentially beneficial for brain aging , but replication is needed.
These findings suggest that longitudinal MRI measurements have potential to serve as surrogate markers to complement clinical assessments for future disease-modifying trials in PD.
These findings suggest that lower muscle quality among HIV-infected persons may be a risk factor for impairments in physical function with aging.
These findings suggest that male sex , low SES , and African American ancestry may represent imprecise generalizations as risk factors for subclinical cardiovascular disease.
These findings suggest that maternal diet modulates the age-associated changes in Cidea expression through several mechanisms.
These findings suggest that methylation may be a potential mechanistic explanation for APOE functions related to aging and call for further molecular mechanistic studies.
These findings suggest that mortality patterns in primates are shaped by local selective forces rather than phylogenetic history.
These findings suggest that Ngb functions as a metabolic regulator and enhances cellular anabolism through the inhibition of AMPK signaling.
These findings suggest that not all exonic indels in FUS cause disease.
These findings suggest that @number@ neural mechanisms , dedifferentiation and compensatory neural recruitment , underlie age differences in face processing.
These findings suggest that OLA1 plays an important role in centrosome regulation together with BRCA1.
These findings suggest that older adults may be more motivated than young adults to obtain social and health rewards immediately and with certainty.
These findings suggest that passive exercise could be a concurrent therapy for cognitive decline in PD.
These findings suggest that phosphodiesterase @number@ inhibitors represent viable pharmacologic interventions to improve muscle function.
These findings suggest that physical activity , notably aerobic training , could be a good exercise strategy for patients with Parkinson's disease.
These findings suggest that physical symptom frequency may become an increasingly important feature of GAD in later life.
These findings suggest that plasma esRAGE plays a role in modulating inflammation , although the exact mechanisms remain to be elucidated.
These findings suggest that positive feedback mechanisms regulate FoxO1-dependent SIRT1 transcription and indicate a previously unappreciated function for FoxO1.
These findings suggest that POTEF-AS1 would play a key role in the progression of prostate cancer by repressing Toll-like receptor signaling.
These findings suggest that process-based cognitive training may be a viable method to address the cognitive impairments associated with ED.
These findings suggest that public health and policy concerns that obesity would continue to become more disabling over time have not been borne out.
These findings suggest that reduced age-related associative deficits under unitized condition may be associated with the presence of familiarity-based retrieval of compounds in older adults.
These findings suggest that reduction of p75 can ameliorate some of the primary symptoms of AD.
These findings suggest that regular strength training can be beneficial for cerebrovascular health in women.
These findings suggest that SDF-1 levels are linked to bone homeostasis.
These findings suggest that senescent cells can cause certain chemotherapy side effects , providing a new target to reduce the toxicity of anticancer treatments.
These findings suggest that SIRT6 plays an important role in the regulation of senescence of human chondrocytes.
These findings suggest that statin may have the potential to prevent the catabolic stress-induced chondrocyte disability and aging observed in articular cartilage.
These findings suggest that stemming the rate of increase in emergency admissions of older people may be feasible , if challenging , despite population ageing.
These findings suggest that studies designed to investigate the age effect in TBPM tasks should consider the contribution of temporal mechanisms.
These findings suggest that Tai Chi and resistance training combined with diet intervention might be beneficial for community-based programs aiming to improve cognitive function.
These findings suggest that tangle pathology , hippocampal sclerosis , TDP-43 and perforant pathway synaptic loss are the major contributors to dementia in the oldest-old.
These findings suggest that Tbata modulates thymus function by regulating stromal cell proliferation via the Nedd8 pathway.
These findings suggest that temperament and character traits follow different kinds of developmental trajectories.
These findings suggest that the enlistment of phasic NE activity may be specific to approach-oriented motivation in older adults.
These findings suggest that the insular cortex could be the core region involved in central visceral processes associated with subjective feelings.
These findings suggest that the neural response associated with emotional empathy lessened with age , whereas the response to perceived agency is preserved.
These findings suggest that the pathogenesis of coronary spasm differs from that of atherosclerosis.
These findings suggest that there is efficacy to continued risk factor management in the elderly.
These findings suggest that there may be other genetic or epigenetic factors contributing to the pathogenesis of FTD in the south Indian population.
These findings suggest that these dyadic relational resources should be enhanced for family caregivers of patients with dementia to ease their caregiving role strain.
These findings suggest that these processes might be related to QOLMQ in healthy young adults.
These findings suggest that the skull is substantially affected by decreased bone metabolism resulting from osteoporosis.
These findings suggest that the vertical postural strategy changes in the elderly during the backward COP shift.
These findings suggest that transplanted MSCs may be able to differentiate into the tenogenic lineage and contribute their own proteins to tendon healing.
These findings suggest that trichlorfon is potentially neuropathic , whereas acephate is not.
These findings suggest that unitization enhances the contribution of both familiarity and recollection processes to associative recognition.
These findings suggest that utilizing a stylus and increasing surface friction may improve touchscreen use in older adults.
These findings suggest that variability may be a characteristic of both fluid and crystallized intelligence in aging.
These findings suggest that VENs may represent a specialized Layer V projection neuron for linking cortical autonomic control sites to brainstem or spinal cord regions.
These findings suggest that verbal influences on spatial / map learning in older adults depends on explicit instructions or environmental support at encoding.
These findings suggest that verbal information is concurrently encoded with spatial information and influences younger adults ' spatial information retrieval.
These findings suggest that with aging self-rated health and personality traits are increasingly important for subjective age.
These findings suggest that WRS represents a distinct progeroid entity that may be caused by recessive mutations of a different gene.
These findings suggest that zinc , via MT buffering , can be a single mediator in modulating neuroendocrine-thymus interaction in ageing.
These findings suggest the benefit of incorporating quantitative MRI acquisitions in a comprehensive clinical evaluation of OA.
These findings suggest the continued importance to assess older women's attitudes when discussing preventive services.
These findings suggest the individual variation of human PIMT levels may significantly influence the course of age-related central nervous system dysfunction.
These findings suggest the need for co-operation between nursing staff and oral care services.
These findings suggest the possibility of rejuvenating , or at least dampening , stem cell aging phenotypes in the elderly for therapeutic benefit.
These findings suggest the potential immaturity of the attentional mediation of MOC inhibition in tested children.
These findings suggest treatment with vitamin D compounds results in sustained increases in VDR in human skeletal muscle.
These findings support a model in which neurodegeneration selectively targets both the DMN and syndrome-specific vulnerable networks at the earliest clinical stages of AD.
These findings support a model linking increased hippocampal activation to subsequent Aβ deposition and cognitive decline.
These findings support and extend the WM model for Ease of Language Understanding.
These findings support an emerging conceptual framework in which NPS constitute an early clinical manifestation of AD pathophysiology.
These findings support a role for the MEOX proteins in promoting endothelial dysfunction.
These findings support a specific link between amyloid pathology and neural dysfunction in PMC and elucidate the underpinnings of age-related memory dysfunction.
These findings support continual efforts to improve the PPV23 coverage rate in vulnerable populations.
These findings support programs encouraging older adults to decrease sedentary behavior regardless of their engagement in moderate or vigorous activity.
These findings support recent data showing an age related decline in the ability to form conjunctive representations.
These findings support speech production models that allow for bidirectional activation between conceptual , lexical , and phonological forms of words.
These findings support that symptoms and complaints of frail elderly are complex.
These findings support the hypothesis of a specific context memory deficit in older adults.
These findings support the hypothesis that higher postmenopausal endogenous estrogens may protect against kidney stones with ageing.
These findings support the hypothesis that LAP2α and nucleoplasmic lamins are regulators of adult stem cell function and tissue homeostasis.
These findings support the hypothesis that rivastigmine may affect frontal subcortical circuits , which potentially contributes to observed clinical improvement associated with EF.
These findings support the importance of a healthy diet in multi-interventional programs to prevent COPD.
These findings support the notion that de novo mutations are responsible for a certain proportion of sALS.
These findings support the notion that resiliency is associated with physical and psychological well-being.
These findings support the use of central blood pressure as a treatment target in future trials.
These findings support the use of telephone-based MI for increasing physical activity in older adults in the short-term.
These findings support the vascular depression hypothesis.
These findings support the view that verbal labeling can influence the regulation of behavior by selectively attracting attention to relevant information in a given task.
These findings therefore do not support a role for SLC1A2 rs3794087 in susceptibility to ET in the North American population.
These findings underscore the importance of addressing age and sex differences when formulating prevention strategies.
These findings underscore the importance of a life course approach to the study of cognitive impairment with aging.
These findings underscore the importance of obesity prevention to reduce the disability burden among older adults.
These findings underscore the importance of routine follow-up of all MMC patients with shunted hydrocephalus and will aid in counseling patients and families.
These findings underscore the need for improvements in data collection and diabetes screening and management , along with policies that support these improvements.
These findings underscore the significance of sleep problems and present potential targets for interventional studies that aim to improve fatigue in older adults.
These findings unequivocally document that increased vitamin K intake reduces the uncarboxylated form of Oc.
These findings validate the expected differences in skin impedance between individual patients and in the same patients during the treatment pulse.
These findings warrant further functional investigation.
These findings warrant further investigation of the roles that urban factors play in the development of elderly rhinitis and allergen sensitization.
These findings were also coherent with observations of positive relationships between intracranial pulsatility and ventricular volume.
These findings were also not affected by high intensity training.
These findings were confirmed by principal component analysis ( PCA ) .
These findings were confirmed in our adjusted analyses.
These findings were consistent even after further adjustment of total sleep time and sleep disordered breathing.
These findings were consistent in both samples , collected with different methods and over different time periods , thus indicating high validity.
These findings were consistent in the @number@ treatment groups.
These findings were consistent with an oncocytoma of the skin.
These findings were corroborated in the validation study.
These findings were independent of advancing chronologic age.
These findings were independent of other cognitive functions.
These findings were independent of white matter burden and cerebrovascular reactivity and thus cannot be accounted for by individual differences in neurovascular health.
These findings were moderated by family negativity.
These findings were more evident in participants with a magnesium dietary intake lower than the Recommended Dietary Allowance.
These findings were not modified by APOE genotype or use of cholesterol-lowering medications.
These findings were observed not only in EGFR-TKI-sensitive cells but also in EGFR-TKI-resistant cells ; even in cell lines harboring K-ras mutations.
These findings were replicated in the Alzheimer's Disease Neuroimaging ( ADNI ) study.
These findings were significantly correlated with age.
These findings were similar for the Framingham Heart Failure risk score except when LV mass was indexed to fat-free mass.
These findings were validated in an independent , existing cross-sectional dataset including @number@ participants from ages 6-87.
These findings will assist researchers , policy makers , and transport providers to set evidence-based strategic directions for creating age-friendly bus systems.
These findings will be essential for guiding further preclinical and clinical studies.
These findings will be useful for the further development of histone H3 peptide based LSD1-selective inhibitors.
These findings will be useful to assess the potential benefits of foods with high polyphenol content.
These findings will , facilitate future studies of WMH in normal aging and in patients with stroke and other cerebrovascular , disease.
These findings will herald new era in the pathophysiology of elderly asthma.
These findings will inform the design of more thorough and potentially more effective disability prevention strategies.
These findings will inform the development of future antimicrobial stewardship strategies ( AMS ) in this setting.
These findings will offer a novel insight into the pathogenesis of cataract.
These findings would be consistent with greater GABAergic inhibitory activity within motor cortices of older subjects.
These findings would likely promote more research to investigate the pathogenesis of POCD.
These fit indices indicated a good fit of the model @number@ and inadequate fit of model @number@ to the data.
These five steps ensure correction of jowling , a smooth jawline , and a well-shaped neck.
These flavors may have contributed to lower consumer overall like and flavor ratings for dry-aged M. spinalis thoracis and M. gluteobiceps.
These fMRI activation increases were associated with longitudinal declines in WM microstructure in a portion of the corpus callosum connecting the increasingly recruited frontal regions.
These foundational pillars should be incorporated into the development and application of MOC in order to achieve desired outcomes.
These four elements served as the foundation of the Model of Successful Aging.
These four factors were associated in different degrees to vestibular abnormalities and falls.
These four regions were then tested in samples from @number@ healthy toy poodles , and correlations were detected in two regions.
These fractures are almost always due to low impact injuries in osteoporotic bones.
These fractures are associated with a significant in-patient mortality and health care resources utilization.
These fractures cause substantial morbidity , and the mortality following hip fracture is greater in men than in women.
These fractures increase the risk of subsequent fractures , especially in the first @number@ years.
These fractures tend to result in displacement in elderly people because they have osteoporotic bone.
These fragments promote the synthesis of matrix metalloproteinases ( MMPs ) that further aggravate the damage to the ground substance and add to fragment accumulation.
These frailty scales capture related but distinct groups.
These functional enhancements of HDL can prevent and / or attenuate aging-related diseases , hypertension , diabetes and coronary heart disease.
These functions are predicted to be involved in regulation of spontaneous action potential ( AP ) generation of these cells.
These functions diminish in the SC during aging , leading to impaired integrity and transcytosis.
These functions may shift during aging.
These functions of p53 facilitate maximal efficiency and survival of cells under conditions of physiological stresses.
These fundamental differences between GAS and SOL sensitivity to altered tendon compliance seem to arise from the biarticular nature of GAS.
These fundamental insights will aid the interpretation of further research into aging and clinical conditions related to disturbed lymphocyte dynamics.
These gender disparities remained significant until controlling for potentially confounding variables.
These gene expression states are encoded in the epigenome - a collection of marks on DNA or on histone tails that are established during embryogenesis.
These gene mutations can cause either loss or gain of function in their respective proteins leading to autosomal recessive and autosomal dominant PD , respectively.
These genes are associated with type @number@ diabetes , lymphoma , actin filament assembly , drug and xenobiotic metabolism , and zinc finger proteins.
These genes are implicated in hippocampal plasticity and stress reactivity , suggesting that dysregulation of these pathways may contribute to LLD.
These genes are involved in early inflammation and innate / adaptive immunity.
These gene sets were then tested for enrichment of association in GWASs of schizophrenia and bipolar disorder.
These genes have previously been associated with neuropsychiatric phenotypes.
These genes included those that function in the immune system , cell cycle regulation , and DNA damage response.
These genes integrate longevity pathways and metabolic signals in a complex interplay in which lifespan appears to be strictly dependent on substrate and energy bioavailability.
These genes represent new candidate genes to study the molecular basis of healthy skin aging.
These genes were enriched in GO terms and canonical pathways associated with immune system functions , particularly phagocytosis.
These genetic abnormalities have rarely been studied in Asian FTD populations.
These genetic manipulations also correlate with a delay in the onset of tissue and organismal dysfunction.
These genetic similarities prompted the belief that chimpanzees can serve as an ideal model for human disease conditions and vaccine development.
These genetic studies establish that 53BP1 , but not other components of the NHEJ machinery , can inhibit the early resection step of HR.
These genome-wide mutation catalogs are valuable resources for the characterization of the underlying mutational mechanisms.
These geometric changes may be related to degradation and fragmentation of intramural elastin.
These gifts enchain others in relationships of reciprocity.
These gifts play a crucial role in building good care relationships that sustain participants ' moral personhood.
These global effects highlight a novel role of mdx ESCs in triggering muscular dystrophy even when only low amounts are present.
The segmental motion of each functional unit was measured using flexion / extension MR imaging , and their relationships with ISL grades were identified.
The segmental premature aging disease Hutchinson-Gilford Progeria syndrome ( HGPS ) is caused by a truncated and farnesylated form of Lamin A called progerin.
The segmentation method relies on a probabilistic atlas of the brainstem and its neighboring brain structures.
The segment of cayenne was complete in five cases ( @percent@ ) and scattered in three cases ( @percent@ ) .
These goals are discussed , as well as the emerging issues that may change the way dementia cases are classified.
These granules appear clustered mainly in the stratum radiatum of the CA1 region and increase in number and size with age.
These groupings seem to be a logical context-appropriate derivation from previous findings on generally held stereotypes of older persons.
These groups served as reinforcements and had @number@ mass ratios of fillers ( filler + resin ) at @percent@ and @percent@.
These growth factors are widely viewed as detrimental for long life by reducing tissue resistance to oxidative stress.
These guidelines and standards provide recommendations for adequate nutritional care and assistance for the institutionalized elderly person based on the scientific state of the art.
These guidelines should not only enable the development of an appropriate definition of SE but also a conceptually sound way of measuring the construct.
These GWAS have yielded important new insights into the genetic mechanisms of AD.
These hallmark pathologies are often accompanied by the presence of reactive microgliosis and the loss of neurons , white matter and synapses.
These hallmarks are typically seen in older HIV uninfected general population and are associated with aging and the immunosenescent phenotype.
These hallmarks of aging suggest a switch from predictive to reactive motor control.
These hands-on training programs combined experiential , didactic , and mentoring elements.
These hardships are known to affect the health status of people as they age.
These have a greater influence on shopping difficulty than income in both sexes , and proximity to a supermarket in women.
These have arisen due to inappropriate age limits in randomized controlled trials and the near-universal exclusion of frail older people from studies.
These have been shown to be psychobiological in nature.
These have to be followed by individual nutritional interventions using a holistic perspective which may also contribute to reducing the risk of falling.
These healthy-aging sites ( HASs ) are located in intergenic regions at 12q13-14.
These hemodynamic changes are associated with an increased incidence in cardiovascular diseases ( CVDs ) and strokes.
These heterocyclic compounds play an important role in a variety of areas , but stand out in the field of Medicinal Chemistry.
These heuristics were then analysed with experts.
These high Cu concentrations in edible apple snail soft tissue might pose a risk to Florida apple snail predators , including the snail kite.
These higher molecular weight materials have increased values of log P compared to A2E.
These highlighted genes and pathways will be able to inform future research , including results for psychiatric disease.
These hilar marginal hepatocytes seem to be derived not from the fetal ductal plate , but from the liver parenchyma.
These hippocampal volume abnormalities in smokers may be related to the deficiencies in episodic learning and memory in young-to-middle-aged smokers reported in previous studies.
These histologic patterns do not change when biopsies are examined at @number@ weeks.
These homologues are considered as candidate or putative ageing-related genes.
These hormones exhibit antioxidant properties and decrease oxidative stress and apoptosis.
These , however , still lack the ability to combine immediate , short-term and long-term aesthetic results with no downtime.
These hyaluronic acids are either more highly cross-linked or larger in particle size than the less-viscous subtypes.
These hyperintensities may represent the structural correlate to the cerebellar symptoms observed in these patients.
These hypotheses are anchored by studies of healthy older individuals where age is presumed the sole influence.
These hypotheses , however , should be formally tested before any definite conclusions on effects of arts on ageing can be drawn.
These identified biomechanical differences could be used to evaluate dynamic balance in persons with MS and to help improve fall prevention strategies.
These identity challenges influenced decisions on whether to retire.
These IgG antibodies regulate the balance of immunologic tolerance and autoimmunity via Fcγ receptors ( FcγRs ) .
These images are used to quantify the deformations developed in the lens as a consequence of the centripetal forces induced by the rotation.
These images have anecdotal success , and systematic research has found they lead to accurate recognition rates comparable to outdated photos.
These images should be properly interpreted in order to avoid unnecessary follow-up examinations and radiation exposure.
These imaging findings must be interpreted in the context of the patient's clinical condition.
These imaging markers may be integrated into clinical decision making to attain better treatment outcomes in the future.
These impacts can be compounded by other factors such as location and age.
These impairments are important contributors of walking limitations related to diabetes.
These impairments have usually been explained by a phonological transmission deficit hypothesis or by an inhibitory deficit hypothesis.
These impairments in the H1 homozygotes were accompanied by an altered blood-oxygen level-dependent response in the medial temporal lobe during successful memory encoding.
These impairments in untrained middle-aged males can be minimized through regular aerobic exercise training.
These impairments may precipitate and perpetuate suicidal crisis in depressed elders.
These important splicing regulators have been implicated in age-related disease , and in the ageing process itself.
These improvements may be substantial.
These improvements though significant were independent of the changes in prostate volume.
These improving support ratios raise per capita consumption , other things equal , but eventually deteriorate as the population ages.
These include alterations in the metabolism of nitric oxide and prostanoides , endothelin-1 , thrombomodulin and Von Willebrand factor.
These include antifibrinolytic agents , autologous blood transfusion drains , avoiding the use of drains , and modifications in drainage techniques.
These include : antioxidants , neuroinflammation inhibitors , anti-apoptotics , neurotrophic factors , AChE inhibitors , mitochondrial function modifiers and cell based therapies.
These include arguments on advance directives and the concept of extraordinary treatments.
These include caloric restriction , rapamycin , resveratrol , GDF11 , mitochondrial antioxidants and cardiolipin-targeted therapeutics.
These include chromatin remodeling , mitotic chromosome segregation , protein homeostasis , and transcriptional elongation.
These include chronic migraine , chronic tension-type headache , new daily persistent headache , and hemicrania continua.
These include conservative management with cast immobilization or surgical options : internal fixation , external fixation , percutaneous pinning , and bone substitutes.
These included eight observational studies ( six being prospective ) , and one clinical trial.
These include early and postnatal development , injury , cancer , memory , aging , and neurodegenerative and psychiatric disease states.
These include , e.g. , flavonoid and non-flavonoid compounds in fruits and vegetables , and n-3 polyunsaturated fatty acids ( PUFA ) in oily fish.
These include humanin , and the recently discovered mitochondrial open reading frame of the 12S rRNA-c ( MOTS-c ) .
These include Hypertension , diabetes and dyslipidemia , all risks factors from CVD development.
These include limited financial resources , task oriented staff and disease-related characteristics of residents.
These include lowered risk of disease and disability , maintenance of high levels of mental and physical function , and continuing social engagement.
These include miRNA-9 , miRNA-34a , miRNA-125b , miRNA-146a , and miRNA-155.
These include molecular tools frequently used for the immortalization process.
These include muscular dystrophy , cardiomyopathy , lipodystrophy , peripheral neuropathy and premature aging syndromes such as progeria.
These include notch signaling , which represents a potential therapeutic target for increasing bone formation in humans.
These include peroxisome proliferator-activated receptor gamma activation and other still poorly defined mechanisms.
These include providing family , acceptance and a home , which can have an impact on outlook and outcomes.
These include severe perturbations to the nuclear shape and lamina , increased DNA damage , and slow growth rates due to mitotic delay.
These include steatosis , inflammation , fibrosis and cirrhosis , which , when taken together , sequentially or simultaneously lead to significant disease progression.
These include stress hormones such as cortisol and growth factors.
These include technological complexity and change , age-related capability changes and a lack of learning and support mechanisms.
These include the insulin / insulin-like growth factor-1 , sterol-regulatory element-binding protein , and AMP-activated protein kinase signaling pathways.
These include thermotherapy , 532-nm laser photo-selective vaporization of prostate , and bipolar plasma vaporization of prostate.
These include visceral adiposity , lower sex steroid hormones , smoking , depression and periodontal disease.
These include wrinkles , hyperpigmentation , lack of firmness , poor texture , enlarged pores , and dryness.
These inclusions contain components of the ubiquitin-proteasome system and α-synuclein confirming that the ubiquitin-proteasome system plays an important role in protein aggregation.
These increases in circulating steroid concentrations are qualitatively similar on average between ethnicities but quantitatively different between individual women.
These independent observations cannot provide evidence for a causal relationship , mediated by telomere length , between FAB and increased breast cancer risk in daughters.
These indexes are based on composite scores of neuropsychological tests validated in English-speaking populations , and their use in aging research is growing in popularity.
These indicators examined improvements in cardiovascular performance , muscular strength , muscular endurance , and flexibility.
These indicators showed dose-response relations with admission to hospital , but not with death.
These indicators were designed to be applied to people aged @number@ years and over , regardless of residence and other characteristics.
These individuals also exhibited an absolute increase in the effector / effector memory CD4 ( + ) and CD8 ( + ) cells with age.
These individuals have exponentially higher osteoporotic fracture rates and immobility impairments compared to independently living individuals.
These individuals were classified according to their smoking habits and hypertensive condition.
These individuals were followed from intake assessment , with @number@ ( average ) longitudinal cognitive assessments.
These individuals were then followed for @number@ years using registry data on mortality.
These inefficiencies may become manifest as frailty , often in the presence of disease.
These inflammatory responses often become chronic and non-resolving and can lead to arterial damage and thrombosis-induced organ infarction.
These influences are critically reviewed , with emphasis on data from aged organisms and senescence-accelerated animals.
These inhibitors also potently inhibited 11β-HSD1 activity in intact HEK-293 cells expressing the recombinant enzyme and in intact primary human keratinocytes expressing endogenous 11β-HSD1.
These inhibitory effects of regucalcin were weakened with aging.
These initial findings encourage further research and development of this imagined gait protocol as a tool for improving gait and cognition among the elderly.
These initial findings encourage the future use of resting-state fMRI as tool in developing a comprehensive understanding of age-related mobility impairments.
These inmates suffer from age-related pathologies or disabilities but still have the cognitive capability required to give their consent to take part in this interview.
These innovations can improve health outcomes , quality of life and efficiency of care processes , while supporting independent living.
These innovative results suggest that , by accumulating in atherosclerotic plaques , the two oxidized lipids may contribute to plaque instability and rupture.
These insights are potentially important for understanding the functional consequences of altered Achilles tendon compliance due to aging , injury , or disease.
These insights from the literature provide a foundation for future mentoring program development.
These insights help in the understanding of women's advance care planning.
These insights would also be helpful in deciphering the detailed hyperglycemia-related biochemical mechanisms for the development of new therapeutic agents.
These insults lead to the pathogenesis of a range of disease states , including atherosclerosis.
These intake regimens were maintained in both groups for @number@ weeks.
These interactions add to the knowledge about cohort differences and age changes in triathlon performance.
These interactions explained @percent@ , @percent@ , and @percent@ of the variance in amyloid deposition respectively.
These interactions have been demonstrated to reflect the biological age and function of renal allografts.
These interactions modulate cell phenotype and produce a variety of effects conditioning the specific functions of tissues.
These interactions remained significant after multiple comparisons adjustment.
These interactions were investigated in healthy young adults , healthy older adults , and elderly fallers , who performed level walking at a self-selected speed.
These interactions were mediated by positive correlations in females and negative correlations in males.
These interventions have been proposed by literature based on clinical experience.
These interventions have had promising outcomes in animal models.
These interventions include inhibition of the mammalian target of rapamycin and lifetime deficiency in GH / IGF-1 signaling.
These interventions will almost certainly include both medical and lifestyle strategies.
These interviews were analyzed using thematic analysis.
These interviews were scored by three independent raters.
These investigations aimed to obtain more insight into the age-related and OA-related subchondral bone adaptations.
These in vitro antithrombotic properties were further supported in an in vivo model of thrombosis.
These in vitro culture systems are enabling the development of new approaches for modelling and tackling diseases of the brain and CNS.
These iPSC-MSCs were capable of forming osteogenic structures in scaffolds and nanofibers.
The SEIQoL index was strongly correlated with a single 10-point rating of current QoL ( rho = @number@ P = @number@ ) .
These issues are addressed in this review.
These issues need to be taken into account when prescribing antimicrobial agents to older complex patients taking multiple drugs.
These items , along with abstracted medical record data , were descriptively analyzed.
These items were analyzed to compute frequency and percent.
These kinematic measures offer the potential to identify early markers for the risk of developing knee OA with aging.
These knockout mice show overt motor disability on aging and clear indications of motor impairment with appropriate testing at an earlier age.
These large clumps of chromatin also eventually disappeared , giving rise to cells resembling cytoplasmic ghosts , a condition which was TUNEL-positive.
These laser and light source treatments are performed sequentially.
These last two variables influenced the perception of quality of life directly , the former positively and the latter negatively.
These latent dimensions , or \ "topics , \ " provide a sparse summary of the generative process behind the features for each individual.
These latent groups differed in psychological , experiential and neurobiologic factors that have been previously shown to be associated with cognitive decline.
These latter are characterized by a condition of chronic physical inactivity.
These latter cases may require specific therapeutic strategies.
These lay perceptions also significantly varied among these elderly individuals.
The selected classification included five clusters that differed with regard to admission criteria , services offered and recreational activities.
The selected homes were selected as a cluster sample from @number@ homes operated by one carrier.
The selected topics illustrate the principles of these paradigm shifts and should serve as a guide to further research and development.
The selected trials ( n = @number@ ) were published between @number@ and @number@
The selection of actions , and the vigor with which they are executed , are influenced by the affective valence of predicted outcomes.
The selection of appropriate patients for SET can partially ameliorate the overall loss.
The selection of described QOL measurements was very heterogeneous in these @number@ studies.
The selection of particular BZDs for older patients should be carefully evaluated.
The selection of patients to be subjected to laparoscopic lavage must be very rigorous.
The selection of spectrophotometry was based on its ease of use as a routine analytical technique.
The selection of surgical approach should be individualized , the principal of damage control surgery should be followed.
The selection of these aged human HSC clones may be in part due to changes in the aging bone marrow microenvironment.
The Selection , Optimization , and Compensation model guided our analysis and interpretation of participants ' responses.
The selection process resulted in the final sample of @number@ studies.
The selective neuropathology in HD is also found to associate with the preferential accumulation of the disease protein huntingtin in neuronal cells.
These levels were correlated with urinary 8-OHdG levels.
The self-adhesive resin cement showed the highest water sorption and solubility.
The self-administered IPSS and SHIM questionnaires were translated in the local language ( not validated yet ) as well.
The self-perceived stiffness intensity of the ankles was assessed in fibromyalgia subjects by means of a visual analogue scale.
The self perception of vocal aging was related to the professional or non-professional use of the voice.
The self-rating instrument AQ was found to be highly discriminative between the HFA / AS group and the healthy control group.
The self-renewing capability of the epidermis , which provides vital barrier function , is diminished with age.
The self-reported adherence rate to exercise at @number@ months was @number@ per cent.
The self-reported prevalence rates of hypertension and diabetes were @percent@ and @percent@ , respectively.
The self-report personality scales were not considered during consensus diagnostic conferences.
The self-terminating approach was associated with better task accuracy.
These limitations are mainly related to the concomitant sheer diversity , chemical complexity , and variable abundance of the various derivatives to be characterized.
These limitations in motor functioning reduce the capacity to work , social participation and the clients ' quality of life.
These limitations present opportunities for improving the functional impact of stroke rehabilitation.
These limitations warrant well-designed large-scale research to examine effects of non-pharmacological interventions on behavioral symptoms of FTD.
These linkages , which we termed sensitivity , varied significantly across participants.
These lipid changes , which suggest extensive membrane remodeling , may contribute to membrane instability and synaptic loss in AD and reflect neuroinflammation.
These locally generated particles , together with aging processes , dramatically affected aerosol composition producing internally mixed particles.
These loci are not risk factors for sporadic ALS and Parkinson's disease in the western Han Chinese population.
These long-lived BMS permit the rapid regrowth of tumour vasculature upon treatment cessation and promote resistance to VEGF-targeting drugs.
These M2-like macrophages demonstrate altered responses to stimuli.
These magnitudes of effect are comparable to those observed in efficacy trials of some antihypertensive drugs.
These main effects were qualified by significant interactions.
These major findings in humans are discussed in the context of differences in population-based trends in blood pressure and orthostatic intolerance.
These major regional socioeconomic inequalities indicate a potential for improving cancer care and survival in Germany.
The SEM and CR results as presented in Table @number@ support these findings for some of the parameters.
These marginal neurofunctional changes in high-performing older adults are discussed in terms of task demands.
These markers appear highly promising , but for better application to forensic casework sample analysis the proposed markers and genotyping methods must be tested further.
These markers decreased in patients who did not meet the requirement , but were stable or increased in those who did.
These markers of vulnerability may identify targets for differing pre and poststroke medical management and rehabilitation among older adults at risk of poor stroke outcomes.
These markers should be investigated in larger , longitudinal studies to determine their potential as biomarkers for frailty.
These masses , which protrude from the mouth floor , may complicate the fitting of dentures and require surgery.
These materials have advantages and disadvantages.
These may affect both pharmacodynamics and pharmacokinetics , but not necessarily drug metabolism.
These may affect the sex difference in the cardiovascular disease prevalence quite a few.
These may allow cellular ruin even at low IR levels.
These may be physiological or caused by additional factors damaging the organ.
These may be the result of both gene mutations that lead to intrinsic perturbations and environmental changes that may stimulate signaling in the body.
These may delay or slow down the degenerative process for a while , but they can neither stop nor reverse its progression.
These may lead to a delayed hypersensitivity reaction.
These may , therefore , potentially serve as biomarkers of ageing.
These meaningful results were replicated in a second experiment and suggest a decrease in conflict interference resulting from positive cognitive state priming.
These means are over @number@ SD below the norms.
These measurements include the area and volume , and the length , width , and girth of the liver ( IRB HUM00041441 ) .
These measurements may contribute to the identification of individuals at high fracture risk.
These measurements were compared across homeostatic sleep pressure conditions and age groups.
These measurements were obtained in millimeters at the locations where halo pins would normally be placed.
These measures use just a fraction of the information in the raw accelerometry data as they are typically summarized at the minute level.
These mechanical and biological properties change significantly as a function of age.
These mechanisms are all known to affect the ageing process.
These mechanisms are extensively interlinked and point to an optimum range of calorie intake , above calorie deprivation and below burdensome calorie excess.
These mechanisms are reviewed in the present article.
These mechanisms can be classified as intrinsic senescence processes , alterations in endogenous anabolic factors , and changes in local support.
These mechanisms include autophagy , ubiquitin-mediated turnover , apoptosis , mitochondrial quality control and cardiac matrix homeostasis.
These mechanisms include genetic modulations , telomere shortening , oxidative stress and mitochondrial dysfunction , all markers of cell senescence.
These mechanisms include posttranslational histone modifications , miRNA-mediated post-transcriptional regulation and DNA methylation.
These mechanisms therefore represent potential therapeutic targets in the prevention and treatment of such pathologies.
These mediating variables are just starting to be understood.
These mediators maintain and propagate the senescence process to neighboring cells , and then recruit immune cells for clearing senescent cells.
These mediators were able to trigger DSB and enhanced SA-β-Gal activity in bystander recipient cells treated with conditioned medium from senescent cells.
These medically costly procedures require donor corneas , eye banking , and medical follow-up , with accrued costs.
These medications are not without serious side effects and should be used with caution in older adults.
These medicines are used to augment the cardiovascular function of critically ill patients.
These meiotic errors are thought to increase with aging and may contribute to the increase in aneuploidy observed in advanced maternal age female oocytes.
These memory disturbances may occur during seizures , i.e. ictal memory disturbances , or between seizures , i.e. interictal memory disturbances.
These men had visited our hospital for metabolic screening from @date@ to @date@ .
These metabolic abnormalities could possibly increase the fragility of the brain and then contribute to PD.
These methodological improvements represent a 5-fold increase in recording time and a 4-fold increase in coverage compared to the initial study.
These methods are highly sensitive and specific and allow the characterization of distortions at subcellular and even molecular level.
These methods could advance our ability to implement potentially effective interventions to reduce health disparities.
These methods dovetail with , and add a systematic and rigorous psychosocial dimension to , the personalized medicine and patient-centeredness movements in medicine.
These methods enable the identification of groups of patients with common underlying clinical problems.
These mice allowed us to examine how wild-type neural progenitor cells responded to high levels of Aβ released from neighboring granule neurons.
These mice also show significant abnormalities in basal synaptic transmission , paired-pulse facilitation and long-term depression ( LTD ) .
These mice are rescued from the deficits in learning and memory and hippocampal function which were found in the Tg2576 mice.
These mice could be a powerful tool to study the neurodegenerative mechanisms leading to the disease and help developing specific therapeutic targets.
These mice experienced mitochondrial respiratory chain dysfunction that resulted in O ( @number@ ) ( - ) overproduction.
These mice express P301L-equivalent mutant tau at normal physiological levels from the knockin allele.
These mice resulted almost negative for the expression of Plin2 and p53 at two years of age.
These mice suffer age-associated losses of dendritic spines , nerve terminals , and neurons.
These might concern differently developed underlying cognitive processes such as inhibition or recollection , or different responses to task demands across both tasks.
These milder forms of HAND are often associated with minimal histological abnormalities , and their pathophysiology is unclear.
These mild forms of HAND consist of subtypes , probably reflecting distinct , though possibly overlapping , pathophysiological mechanisms.
The SEM images showed full penetration of adhesive agents when using silane-based primers.
The seminal advance of induced pluripotent stem cell ( iPSC ) technology provided an attractive alternative to human embryonic stem cells.
These minor complications resolved within @number@ month.
The semi-parametric group-based trajectory approach and survival analysis were used to investigate the trajectories of nutritional risk.
These miRNAs directly interfere with ROS-scavenging gene expression , such as TXNL1 and GPX3.
These miRNAs have overlapping targets.
These misconceptions have been disproven.
The SEM is most important for interpreting the real effects of an intervention.
These mitochondrial abnormalities can predispose a metabolic cardiomyopathy characterized by diastolic dysfunction.
These mitochondrial enzymes regulate the level of catecholamines and serotonin by catalyzing their oxidative deamination in the heart.
These mitochondrion-related disorders in peripheral tissues can impact on brain functions through metabolic , hormonal and inflammatory signals.
These modalities may be used with laser resurfacing or chemical peels to address epidermal and superficial dermal problems.
These modalities performed together offer the patient a comprehensive approach to attain a more attractive and youthful facial appearance.
These mode effects were more pronounced with older baseline age , but only for the negative psychosocial measures.
These models are input for detection and segmentation methods.
These models may be useful in identifying patients who might benefit from more expensive or invasive diagnostic testing , and can inform clinical trial design.
These models of extreme inactivity provide a reference to guide physical activity requirements for optimal cardiovascular health.
These models recapitulate early benign lesions and suggest that a latency period exists between loss of PAX2 , p53 mutation and tumor formation.
These models were replicated for AD patients ( @number@ men , @number@ women ) in the 2nd Predictors Study cohort ( 1997-2007 ) .
These models were then applied to the study population to determine each patient's morphometric age.
These models were validated using nitrocellulose-based gunpowders of known manufacture date.
These modest sized P-values were not replicated in a German sample.
These modifications affect penile hemodynamics by impairing cavernosal smooth muscle cell relaxation , reducing penile elasticity , compliance and promoting fibrosis.
These modifications are known to modulate the structure , function , and activity of RNAs.
These modifications can be involved in the regulation of fresh meat quality and influence the processing properties of meat products.
These modifications may take part in the induction of the glaucoma-related ocular surface disease.
These modifications must be taken into account when planning the treatment for younger patients , to minimize the modifications arising from the natural aging process.
These modifications observed during aging are also associated with leptin resistance.
These modifications to disease profiles and the effects upon human pharmaceutical usage are discussed.
These molecular analyses reveal new potential therapeutic targets for cervical cancers.
These molecular and cellular changes provide new information for developing therapeutic strategies for stroke and related vascular disorders treatment.
These molecular motors facilitate a variety of transactions including replication , DNA repair , recombination , and transcription.
These molecules and pathways are critical for prostate development with both known and postulated roles in prostatic pathology.
These molecules are highly brain penetrant and prevent and restore cognitive deficits in mouse models of Alzheimer's disease.
These molecules are immediately neutralized by enzymatic and non-enzymatic systems in a physiological and dynamic balance.
These molecules have been shown to be involved in mood regulation.
These molecules , such as monoclonal antibodies and tyrosine kinase inhibitors , can cause different type of toxicities compared to traditional chemotherapy.
These morphological changes of the disc are linked to alterations of the spine flexibility.
These morphological results should be considered when applying ART in aged patients , rescue ICSI , or artificial oocyte activation.
These morphometric alterations may have impact on the function of the hippocampus during aging and CR.
These mortality observations are directly influenced by widespread use of mammographic screening which has opened a Pandora's box of subclinical DCIS and early invasive lesions.
These MPs exhibited angiotensin-converting enzyme activity and upregulated AT1 receptors and angiotensin-converting enzyme in P1 ECs.
These MRI scans were retrospectively evaluated with a cervical spine ageing scale.
These mtDNA mutator mice have also highlighted that the consequences of mtDNA mutations upon stem cells vary depending on the tissue.
These multicellular interactions are initiated by insoluble tangles of phosphorylated tau protein and plaques of amyloid peptides.
These multifaceted roles of ghrelin make ghrelin and GHS-R highly attractive targets for drug development.
These multifactorial proteins are a group of heterogeneous RBPs primarily implicated in controlling the decay and translation rates of target mRNAs.
These multifunctional molecules were prepared by linking lipophilic moiety ( LA ) to the pentapeptide KTTKS.
These multinational risk estimates can inform resource planning for OA service delivery.
These multiple issues increase the psychosocial toll on nurses during a disaster response and impending recovery.
These muscles are susceptible to atrophy and injury in individuals during menopause , aging , and disease.
These muscles have been implicated in falling in the elderly people.
These mutations also result in persistent activation of STAT3 signaling.
These mutations are believed to abolish the assembly and secretion of apoB-containing lipoproteins.
These mutations have also been shown to cause a disruption in the normal interactions between the A and B lamin networks.
These mutations may play an important role in tumorigenesis and cisplatin-induced apoptotic resistance of most microsatellite-unstable CRCs.
These mutations were associated with either the semantic variant of primary progressive aphasia or the behavioral variant FTD phenotypes.
These mutations were located in transcribed sequences encoding enhancer RNAs ( eRNAs ) and were shown to impair enhancer activity and ACTRT1 expression.
These mutations were more frequent in patients with FTD than in HCs ( @percent@ vs. @percent@ , p = @number@ ) .
These myocilin amyloids are unique as there are no other known pathogenic proteins that accumulate within the ER of TM cells and cause toxicity.
These national and state estimates establish a baseline for monitoring trends among residents living in residential care.
These national and state estimates establish a baseline for monitoring trends among residents living in residential care.
These needs are often ignored in the design , development , trial and adoption of consumer health products resulting in low adoption and usage.
These needs will become even more pressing given the aging society worldwide.
These need to be articulated , shared more widely across practice , policy and education so that we can build on this excellent practice.
These negative associations persisted after plasma homocysteine was controlled for.
The senescence-accelerated mouse prone10 ( SAMP10 ) strain , a model of aging , exhibits cognitive impairments and cerebral atrophy.
The senescence hypothesis of COPD pathogenesis is supported by in-vitro , in-vivo and clinical studies.
The senescence of HSCs was determined by senescence-associated β-gal staining.
The senescence program is realized through autocrine / paracrine pathways based on the activation of a peculiar senescence-associated secretory phenotype ( SASP ) .
The senescence programme is implicated in diverse biological processes , including embryogenesis , tissue regeneration and repair , tumorigenesis , and ageing.
The senescence repair circuit of hypoxia-preconditioned senescent EPCs ( hyp-old EPCs ) was examined in an effort to enhance their regenerative potential.
The senescence response has also become increasingly recognized as an important contributor to aging and age-related diseases , including cancer.
The senescence response is a double-edged sword.
The senescence response prevents cancer by suppressing the proliferation of cells with a compromised genome and contributes to optimal wound healing in normal tissues.
The senescent cells remain chronically present where they can promote local and systemic inflammation that causes or exacerbates many side effects of the chemotherapy.
The senescent HDF CM strongly secreted chemokine ligand @number@ ( CCL2 ) .
These network alterations in MCI A + N + are stronger and more focal than those of MCI A-N + .
These network differences were evident even a year after the acquisition of the different expertise levels.
These neural correlates of executive functions should be further investigated as a potential prodromal neural marker of executive deficits and neurodegenerative processes.
These neurobiological findings may be considered as endophenotypic traits.
These neurodegenerative changes are attenuated in MTs over-expressing wv / wv mice , suggesting the neuroprotective role of MTs in aging.
These neurodegenerative effects potentially include increased risks of impaired cognitive function and dementia , Parkinson's disease , and amyotrophic lateral sclerosis.
These neuroimaging results were consistent with recent findings about the association between sporadic AD and distinct and circumscribed cerebellar atrophy.
These neuromuscular changes are not affected by acute intermittent high intensity aerobic exercise.
These neuropathological features and aberrant brain microRNA ( miRNA ) expression patterns have been implicated in the etiopathogeneses of various neurodevelopmental and aging-related neurodegenerative disorders.
These neuroprotective actions of OXM were mainly mediated through the GLP-1R.
These new actors allow us to identify a bone-kidney axis , whose real physiological importance is still under evaluation.
These new aspects of redox biology may stimulate innovative and multidisciplinary research in cardiovascular physiology and pathophysiology.
These newer methodologies are particularly well suited for discovery of biomarker candidates from human disease samples , and for investigating and understanding human disease pathways.
These new findings should be taken into consideration for future research into developing new treatment strategies for UI in older women.
These new findings show that Asp421-cleaved tau and Aβ cooperate to impair mitochondria , which likely contributes to the neuronal dysfunction in Alzheimer disease.
These newly formed modified molecular species are known as ' advanced glycation end-products' , or AGEs.
These new mouse models , together with the telomerase-deficient mouse model , are valuable tools for understanding human pathologies produced by telomere dysfunction.
These new myelin internodes maybe required for the de novo myelination of previously unmyelinated axons , myelin sheath replacement , or even myelin remodeling.
These new procedures have been developed in an attempt to eliminate , or at least substantially reduce , various systematic errors in Fisher's original experiment.
These new realities need the recognition of basic international social rights , as the experiences of Peruvians living in a migration context in Spain show.
These new technologies and knowledge are changing or have potential to change the future orthopedic medical care.
These nine loci were then compared with genome-wide association scans for diabetic nephropathy ( DN ) in human type I diabetes.
The senior author's preferred approach is liposculpture with fine-cannula liposuction.
The Senior Fitness Test ( Fullerton Test ) was used to evaluate functional fitness.
The Senior-Friendly Hospital framework is valid and important for patient safety and quality improvement.
The senium degree of cells of the 13th passage was higher than that of the 5th passage cells.
These non-AIDS related diseases account for a growing proportion of intensive care unit ( ICU ) admissions in HIV-infected patients in recent studies.
These noninvasive treatments are being sought after because less time for recovery means less time lost from work and social endeavors.
These non-spherical components may reflect the direction-dependent morphology of the microcirculation.
These normograms can then be used by counselors to help the participant adhere to their caloric target.
These normograms could provide a reference guide for the clinician in consulting with women with infertility.
These normograms could provide a reference guide for the clinician to consult women with infertility.
These norms link physiological understanding with broader discourses of governmentality , including the professional project of geriatric medicine.
These not only indicate the growing interest in this field but also highlight the importance of cellular senescence in cell biology from yeast to human.
These novel associations refine the ability to predict clinical features caused by certain LMNA missense mutations.
These novel findings indicate that activating α7 nAChR is a promising treatment for cognitive impairment in AD.
These novel findings suggest that an important aspect of the neuropsychology of healthy aging has hitherto been overlooked.
These novel results indicate that the loss lncRNA Abhd11os likely contribute to striatal vulnerability in HD.
These NPs also effectively activated CAs ex vivo , in whole blood experiments , with an increase of 200-280% of the CA activity.
The sensation of solitude increased with age.
The sensibility and specificity of the MNA-SF for the full MNA version were @percent@ and @percent@ , respectively.
The sensitivities for CCS C100 were @number@ and @number@ % for the cutoff points of CRP C3 or @number@ mg / L , respectively.
The sensitivity and specificity for a cut-off score of three were @percent@ and @percent@ , respectively.
The sensitivity and specificity for the 1-h algorithm were @percent@ and @percent@ , respectively , compared to @percent@ and @percent@ for SoC.
The sensitivity and specificity of HbA1c at cutoff @percent@ for detecting IPH was also better than that of IFG.
The sensitivity and specificity of IHC for BRAF ( V600E ) was compared with the molecular biology data.
The sensitivity and specificity of IHC for the detection of this mutation were @percent@ and @percent@ respectively.
The sensitivity and specificity of the GPS-pv were @number@ and @number@ respectively , with a cutoff score of ≥1.
The sensitivity and specificity of the two-stage PHQ- @date@ were @number@ and @number@ respectively , and the AUC was @number@
The sensitivity and specificity values of the new cut-off scores were much greater than @number@
The sensitivity and specificity were not , however , sufficient for the measure to be used alone.
The sensitivity of all four risk scores to detect IPH was better than that of impaired fasting glucose ( IFG ) .
The sensitivity of Asc quantification was sufficiently high to detect regional and developmental changes in Asc concentration.
The sensitivity of impacts to each is unknown because they have never been systematically compared.
The sensitivity of mcDESPOT estimates to SRC boundary conditions , and tissue parameters , was examined using numerical phantoms and acquired in vivo human data.
The sensitivity of surrounding stimulus positions was higher than in the center ( @number@ degrees ) .
The sensitivity of the Mini-Cog varied between @number@ to @number@ in studies while the specificity varied between @number@ to @number@
The sensitivity of the α-adrenoceptors on the SMCs increases with aging.
The sensitivity of this approach to changes with fatigue may have been limited by model simplifications.
The sensitivity threshold was recorded as the minimum monofilament size from which patients could detect at least two of three stimuli.
The sensitivity to dental coverage changes should be considered as insurance and retirement policy reforms are deliberated.
The sensorial functioning and the death and dying domains on the WHOQOL-OLD characterised this particular population's anxieties , wishes and gender needs.
The sensori-motor network showed significant disease effects , with signals suppressed in patients bilaterally in the primary motor cortex.
The sensory modality of the RT task impacted the results with interference being greater for the auditory task compared to the visual task.
The sentence-comprehension task consisted of the canonical and non-canonical word-order conditions.
These nuclear abnormalities are rescued by ectopic expression of wild-type BANF1 , providing evidence for the causal role of this mutation.
These nucleotide alterations are candidates that could play important roles in cancer.
These @number@ could be subjects with combinations of preexisting non-Alzheimer pathophysiologies and tau-mediated neurodegeneration who newly entered the amyloid pathway.
These @number@ factors were independently and significantly related to performance and accounted for @percent@ of the total variability in free recall scores.
These @number@ food items were categorised into forty-six food groups , and dietary patterns were identified using principal component analysis.
These @number@ parameters evaluated for each axis of movement and / or derivations resulted in @number@ sub-parameters.
These @number@ patients underwent infraeyebrow blepharoplasty incorporated with browpexy at Taipei Veteran General Hospital.
These @number@ predictors should influence clinical decision making.
These @number@ presurgical MRI indices were tested as predictors of incidence and severity of subsequent delirium.
These numbers have been quite stable throughout the study period.
These @number@ studies included @number@ patients and executed @number@ kinds of physical activity programs.
These @number@ sub-parameters were analysed in the elderly and young groups and under the open-eye and closed-eye conditions.
These numbers will increase dramatically as both the size of the elderly demographic and the number of those with carbohydrate metabolism-related problems increase.
These @number@ variants are identified to be associated with increased risk of ALS in European-descended populations by genome-wide association studies.
These nutritional allowances are set at the minimum required for health , providing little advice as to the optimal nutritional intake for a given age.
These nutritional guidelines are intended to improve the nutrition and nutritional care of the older population.
These nutritional sensors control mitochondrial biogenesis , dynamics by regulating fusion and fission processes , and turnover through mito- and autophagy.
These objectives are the target of multidisciplinary ongoing and future research activities for a better understanding of the link between diet and ageing.
These observations add to the base of knowledge available on this commonly employed model of tauopathy.
These observations are consistent with experimental findings in the aged population , e.g. , elevated incidence of tumorigenesis and diminished resistance to oxidative stress.
These observations contribute to current knowledge on the effects of LMW HA on keratinocyte biology and cutaneous physiology.
These observations could have far reaching consequences for improvement of immunosenescence and its clinical consequences such as infections , altered response to vaccination.
These observations demonstrate age-related functional declines in GCs , consistent with premature luteinization.
These observations demonstrate disease-related changes in higher order genome organization in HGPS and provide novel insights into the role of lamin-chromatin interactions in chromatin organization.
These observations emphasize the need to tailor UI interventions to specific pelvic floor defects and UI type in older women.
These observations have encouraged the development of therapeutic strategies to treat and prevent telomere-associated diseases , namely aging-related diseases , including cancer.
These observations have implications for the therapeutic strategies to manage postprandial hypotension by modulating gastric emptying.
These observations highlight the modifying effect of salt intake on the association of CYP17A1 with BP.
These observations identify yet another role for these multifunctional factors and provide a hitherto unprecedented mechanism for cellular senescence and nuclear-cytoplasmic trafficking.
These observations indicate the need for further studies to characterize this relationship for staffing of units caring for patients with hip fractures.
These observations in mice and human hearts suggest that aging-related cardiac fibrosis is , at least partially , dependent on the upregulation of ET-1.
These observations led us to hypothesize that there is an upregulation of AA cascade and neuroinflammatory markers in the brain of AD patients.
These observations may be influenced by population diversity , geographic location , and / or specific historic background.
These observations may explain the increased longevity typical of endurance athletes despite the presence of more coronary atherosclerotic plaque in the most active participants.
These observations offer a mechanistic explanation for the tolerogenic properties of the developing fetus and for variable degrees of immune responsiveness at birth.
These observations point at background inflammation as direct , age-independent contributor to an accumulation of the disease burden.
These observations raise the possibility that SIRT1 functions as a novel upstream regulator for AMPK signaling and may additionally modulate tumor cell proliferation.
These observations raise the question : how do we largely avoid cancer for most of our lives ?
These observations should be taken into account in ED design and care planning for old people to maximize efficiency , safety and quality.
These observations suggest a direct FMR1 effect on follicular recruitment and OR and , therefore , on women's fecundity.
These observations suggest that 15d-PGJ₂ shows another biological activity e.g. growth inhibition in HEK293 cells via unknown receptor for 15d-PGJ₂.
These observations suggest that an association between SUA levels and the development of cardiac hypertrophy is more likely in women than in men.
These observations suggest that BD pathology may be associated with apoptosis as well as with disturbed synaptic function.
These observations suggest that coordinated transcriptional changes associated with ageing and calcium homeostasis in the human brain are accelerated in patients with AD.
These observations suggest that HIV-1 infection in older persons can have detrimental immunological effects that are not completely reversed by ART.
These observations suggest that older adults display a rapid mobilization of their neural generators within the parietal cortex to manage very low demanding WM tasks.
These observations suggest that ROCK2 inhibition reduces Aβ levels through independent mechanisms.
These observations suggest that the AGE-RAGE system is a novel therapeutic target for preventing diabetic vascular complications.
These observations suggest that the aging pharynx undergoes structural changes consistent with atrophy.
These observations suggest that TP53INP2 repression would reduce muscle atrophy under conditions that favor protein loss in skeletal muscle.
These observations suggest that tumors that display an augmented APE1 / NPM1 association may exhibit increased aggressiveness and resistance.
These observations suggest that younger PD patients have more efficient compensatory mechanisms.
These observations suggest the presence of previously unsuspected complexes and signaling events required for the replication of the ends of human chromosomes.
These observations support a role for the IL10 gene in dementia pathogenesis by increasing risk of developing MCR in older adults.
These observations support the suggestion of a key role of the cholinergic system in the functional processes that lead to AD.
These observed impairments may reflect underlying physiological differences among individuals who are obese , but that are independent of age.
These observed life-span trajectories for sustained attention are distinct from results of other life-span studies focusing on fluid and crystallized intelligence.
These obvious changes in the CM are likely to make the choroid prone to damage by visible light.
These odds were higher than the ASA and Charlson comorbidity index.
These old animals do not develop oxidative stress suggesting that the D-serine-related pathway could be targeted by the age-related accumulation of reactive oxygen species.
These older adults were more physically active during the morning hours and became more active as the winter season transitioned to spring.
These ophthalmic problems may increase risk of falls or increase the comorbidity from dementing processes and depression.
These opinions were generally consistent across the @number@ countries for each respondent group.
These opposing observations underline an incomplete understanding of the significance of this ancestral hormone pathway in relation to brain aging.
These opposite expression patterns translated into an age-dependent prognostic value in CRC for the individual histone modifications and their combination.
These osteoprotective effects appear to be mediated through antioxidant or antiinflammatory pathways along with their downstream signaling mechanisms.
These outcomes are often accentuated when caregivers and care recipients co-reside.
These outcomes combined with a positive safety profile make ABL an interesting addition to the armamentarium against postmenopausal osteoporosis.
These outcomes introduce a more complex model of E₂ supplementation in coordinating GH secretion in aging women.
These outcomes result from a colonial past and contemporary policies that affect all Aboriginal people.
These outcomes suggest striking similarities between remembering the past and imagining the future in AD.
These oxidative disturbances are also accompanied by reductions in ATP levels , adenine nucleotide pool size and adenylate energy charge.
These oxylipins generally increase inflammation , hypertension , and platelet aggregation , although not universally.
These paradigms stimulate automatic versus controlled triggering of saccades.
These parallels raise questions about the dynamics of biophysical network structures during aging processes.
These parameters , along with a patient's comorbidities and concomitant medications , should be considered when selecting an analgesic and dose regimen.
These parameters also increased in the second age group , but this increase was not significant.
These parameters are better than BMI for predicting physical function and independent daily living.
These parameters correlated with the sebaceous gland size , sebocyte proliferative activity and total blood testosterone level.
These parameters estimate mitochondrial respiration , reactive oxygen species ( ROS ) production , and deoxyribonucleotide ( dNTP ) balance in PBMCs.
These parameters , excluding BMI values , were also significantly associated within sib-ships , suggesting a strong familial / genetic component.
These parameters have not yet been considered together in the same study exploring the possible association between IR and sleep in older patients.
These parameters may be detectable by follow-up monitoring.
These parameters might provide novel therapeutic targets for optimizing antiplatelet therapy.
These parameters of the two groups of AOBs were evaluated.
These parameters shift towards fragile by aging , especially remarkably reduce after @number@ years.
These parameters were also evaluated in the first frozen embryo transfer from these couples ( if they had one ) .
The separate junctions can each be cleaved by DNA structure-selective endonucleases known as Holliday junction resolvases.
These PARP-mediated processes impact on higher order metabolic regulation that modulates lipid metabolism , circadian oscillations and insulin secretion and signaling.
These partial mediations manifested in the same way across all @number@ country samples , regardless of age or gender.
These participants are well-respected , representative elders and traditional healers of their regions.
These participants ' characteristics could reduce the generalizability of study results and , more importantly , mask trial effects.
These participants completed the CIB , the Montreal Cognitive Assessment , and self-report measures of daily functioning.
These participants further showed greater beta M1-cuneus connectivity than the other participants.
These participants were significantly younger and had a history of low muscle tone more frequently than people without unusual sleep postures.
These particles did not give rise to any adverse reactions and were fortuitously discovered by the surgeon during a facelift.
These particles first differed by their morphology and size distribution , with finer particles found in emissions.
These particular signalling molecules are involved in PD pathophysiology , but are also very important in an aberrant coagulation / hematology system.
These pathogenic and suppressive functions are not static and appear to be regulated by the nature and strength of inflammation.
These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons , white matter and synapses.
These pathological findings may aid in the pathophysiological recognition of acute-stage PRES.
These pathways are a link between diet and aging.
These pathways are involved in the development and progression of B cell lymphoma.
These pathways could have synergistic effects on osteogenic gene expression and protein synthesis , thus potentially leading to enhanced bone formation.
These pathways have profound effects on proliferative , apoptotic and differentiation pathways.
These pathways may be targeted to promote successful cognitive aging.
These pathways with TRPV1 converge in the signaling of growth factors with recent work highlighting a relationship with erythropoietin ( EPO ) .
These patients are at an increased risk of an infection caused by a multidrug-resistant pathogen.
These patients are capable of high-intensity strength training , which should optimise gains in physical function , strength and balance.
These patients are frequently excluded from randomized clinical trials evaluating anticoagulants , confounding clinical decision making.
These patients are sometimes treated with clopidogrel.
These patients can benefit from the full range of nuclear medicine studies.
These patients can challenge usual medical decision making because of their unique situation.
These patients display acenocoumarol dose requirement of ≤5.6 mg / week.
These patients frequently require surgical treatment.
These patients had been admitted to our department and underwent a CSF examination between @date@ and @date@ .
These patients had undergone implant removal after a mean time of @number@ days , followed by functional atlantoaxial CT in left-right rotation.
These patients have significantly shorter ET / ICA distances ( @percent@ CI @number@ Y @number@ mm , p = @number@ ) .
These patients inherit CTC1 mutations in a compound heterozygous manner , with one allele encoding a frameshift mutant and the other a missense mutant.
These patients may be misclassified as having COPD on the basis of spirometric results.
These patients may need more extensive infra-inguinal revascularization than isolated iliac angioplasty and stent placement , despite a preserved ankle-brachial index.
These patients must be studied in order to invest in the prevention and treatment of SCI in these patients.
These patients need a procedure that is safe , efficient , and durable , and at the same time carries minimal risk of side-effects.
These patients received an average of @number@ joules of energy between three treatment areas which was delivered at @number@ Watts and @number@ Hz.
These patients represent a unique opportunity to study the potential anti-aging properties of mTOR inhibitors in humans.
These patients should therefore be monitored with special care.
These patients showed a late median disease onset of @number@ years and short disease duration of @number@ months.
These patients showed significant changes in autonomic implicit response compared to the other groups.
These patients showed typical L-DOPA-responsive PD phenotypes.
These patients were also less likely to be hospitalized , experienced less pain , and had better physical and mental health.
These patients were carried to the group of activation also.
These patients were divided by sex and also into three age groups : younger than @number@ years , 61-69 years and over @number@ years.
These patients were divided into @number@ groups according to the CREDOS ischemia classification system.
These patients were followed by clinical , and instrumental assessment , and telemetric device control at follow up.
These patients were followed by clinical , instrumental assessment , and device telemetric interrogations at follow-up.
These patients were followed-up for a mean @number@ years.
These patients were interviewed and re-examined @number@ to @number@ months after initial screening.
These patterning abnormalities include irregularities at the gray-white matter boundary and may implicate early neurodevelopmental events such as migration in altering cortical organization in ASD.
These patterns and their analysis support non-homologous end joining double strand break repair as central to the ageing-relatedness of DNA repair genes.
These patterns can be classified into creases , wrinkles , folds , period-doubles , ridges and delaminated-buckles according to their distinctive topographical characteristics.
These patterns did not change after a high-intensity training session.
These patterns likely reflect differences in health status.
These patterns may reflect adolescent maturation of frontal connectivity supporting cognitive abilities , particularly the protracted refinement of corticolimbic connectivity underlying cognition-emotion interactions.
These patterns of demographic associations with cognitive performance were very similar to those of US cohorts.
These patterns of dream imagery reflect the waking developmental patterns as proposed by social theories and recognized features of aging.
These patterns of results suggest the difficulty in finding the specific neural bases that underlie individual cognitive functions through VBM.
These patterns probably contributed to the older adults ' diminished distractibility by negative task-irrelevant stimuli.
These patterns were irrespective of the student's gender and previous contact experience.
These peptides derive from the amyloidogenic proteolytic processing of the amyloid-β protein precursor ( AβPP ) , through the sequential action of β- and γ-secretases.
These peptides stimulated cell proliferation , differentiation and decreased cell apoptosis.
These perceptions revealed two themes : aging , leisure , and chronic disease ; and knowledge and leisure experiences.
These perceptual changes could be the cause for slower and less accurate subordinate categorization , particularly when it is based on details.
These performed careful validation in blinded cohorts.
These periods of muscle disuse induce muscle atrophy which could worsen the pathology or elderly frailty.
These personal collaborations motivate and advance my research toward understanding cellular communications that promote metabolic health and organism longevity.
These personality variables were also associated with VCDT.
These perspectives are organised via four themes : remaining unmoved , fighting back , emphasising social contributions , and redefining services.
These perturbations involved forward translation of a large ( @number@ × @number@ m ) motion platform configured to simulate a \ "real-life \ " environment.
These phases are characterised by profound periods of transcriptional activity , which define and reinforce lineage decisions.
These phenomena have been associated with cognitive impairments and psychiatric disorders although possible associations with specific patterns of cognitive aging are yet to be determined.
These phenomena suggest that PPARα activation by MHY908 attenuates NOX4-derived ROS generation in response to insulin.
These phenotypes are more heritable ( [ Formula : see text ] ) than gene expression levels.
These phenotypes could also be applied to discover associations with other environmental factors.
These phenotypic changes were found to be dependent on c-Myc activation using the c-Myc inhibitor 10058-F4.
These phosphoproteome data may provide new clues to better understand molecular pathways that are deregulated in the pathogenesis and progression of AD.
These phylogenic and ontogenic features suggest that microglia serve vital functions.
These physicians completed a brief questionnaire about the SQA test.
These physicians require alternative funding and a departmental home within a university if they are to provide an academic service.
These physiological signals from testosterone are modulated through the interaction of testosterone with the intracellular androgen receptor ( AR ) .
These physiologic data will provide veterinarians and researchers with important age- and sex-specific reference ranges for evaluating experimental results from Tibetan macaques.
These physiologic results have clinical significance in understanding the pathophysiology of altered variability in ill patients.
These plans , among other topics , explicitly aim at scientific and research strategies as well as support and healthcare structures.
These plasma samples were selected from postmortem specimens based on these pathological examinations.
These pleiotropic effects indicate the fundamental significance of the potential interplay between neural development and lifespan control.
These plots were originally used in meta-analysis for displaying the treatment effects from independent studies.
These points are of particular importance for new brands emerging in the market.
These policies only have mixed effects on women's health related behaviors.
These polymorphisms are suggested to generate a looped-out primer and a hairpin structure during recombination , substrates on which pol ν can operate.
These population-based estimates may help health care planners and decision-makers set priorities and increase public awareness and interest in the prevention of diabetes.
These populations differed in terms of the distributions of sex , baseline CD4 cell count and death.
These portentous developments will have far-reaching social and economic implications in terms of income security , social welfare and medical services.
These positions tend to focus on the most complex patients and on selected transitions in care.
These positive directions of effects are in agreement with the positive effects on longevity previously reported for these SNPs.
These positive effects seem to compensate the elderly for decreasing social contact with their migrant family members.
These positive findings suggest that the administration of basic fibroblast growth factor may become a useful tool for the treatment of the aging vocal fold.
These positive valence effects are predicted by individual differences in executive function in OAs for the deep but not shallow task.
These potential \ "aging biomarkers \ " might provide additional prognostic / predictive information supplementing clinical evaluation.
These potential anatomical variants should be considered before operating in the presacral space.
These potential barriers are modifiable if couples can learn to cope with sexual losses and accept sexual rehabilitation strategies.
These predictions may justify vaccination programmes , at least in areas of high mosquito abundance.
These predictions provide important information on the cancer burden for cancer control planners , policymakers and the general public.
These predictions were tested in the context of the relatively automatic low-level cognitive process of lexical access ( auditory word recognition ) .
These predictive findings offer a direction for future inquiry into adolescent obesity etiology using causal methods.
These predictors outperformed myo-inositol metrics and traditional predictors ( P ≈ @number@.05-1.0 ) .
These preliminary data offer level-headed evidence to use cord blood ECFC as a cell therapy product in vascular diseases.
These preliminary findings highlight the enhanced diagnostic potential of LAR testing.
These preliminary findings suggest that CCBT and RCBT are equivalent treatments of major depression in persons with chronic medical illness.
These preliminary findings suggest that N170 / VPP could be modulated by the decline related to pathological cognitive aging.
These preliminary results display the first evidence of the utility of the sternal end of the clavicle in aging older adult individuals.
These preliminary results show that above-average memory capacity can be encountered in advanced age.
These preliminary results suggest EA could be a promising alternative treatment for balance disturbance in PD.
These preliminary results suggest that late myelinating frontal pathways may be vulnerable to aging in DS.
These present cross-sectional results indicate that PA is a lifestyle factor that is linked to brain structure and function in late life.
These prevalence estimates were used to derive PPVs and NPVs for existing and potential noninvasive screening tests with varying levels of sensitivity and specificity.
These preventive trials and larger longitudinal population-based studies targeting cognitive outcomes could be useful in further understanding the cognitive-frailty interplay in older age.
These principles emphasize that physical and functional phenotypes of an adult are determined by gene-environment interactions from early life onward.
These problems are frequently unrecognized , underreported , and inadequately treated.
These problems are interrelated , both in how the issues arise and in the effect they have on one another.
These problems are tough to manage because of their social complexity.
These problems have become the major focus for the health care industry.
These problems include facial lipodystrophy and changes in skin and skin texture.
These procedures also improved ratings of perceived success and health in our patient population.
These procedures are well tolerated and are associated with a low risk of side effects.
These procedures require a rigorous training and a distinct learning curve.
These procedures were repeated on samples of commercially available pooled adult normal plasma for comparison.
These processes and differences from younger individuals with asthma are not well understood.
These processes are crucial because mediating the zinc signalling within the immune cells assigning to zinc a role of \ "second messenger \ ".
These processes are regulated by cell-autonomous and intercellular ( paracrine and endocrine ) programs that mediate responses of neural cells to environmental input.
These processes contribute to age-related ECM degradation , production of matrikins ( ECM degradation products with biological activity ) aggravating functional loss with age.
These processes could underlie a better integration of structural and functional communication between brain regions with age.
These processes depend on regulation of chromatin.
These processes include cancer metastasis , vascular calcification , and renal fibrosis.
These processes may explain the premature development of age-related chronic conditions in childhood cancer survivors.
These processes may lead to loss of skeletal muscle and reduced physical performance.
These processes may represent stages in a cascade of age-related maturation in white matter microstructure.
These processes synergistically promote chronic sterile inflammation , insulin resistance , and lipid redistribution away from subcutaneous adipose tissue.
These products are popular and may be used without the direct supervision of a dermatologist , creating a practice gap in educating patients.
These products have been used to treat countless disorders such as musculoskeletal disorders , headaches , and eye disorders , among many others.
These products may be safe when given exclusively to patients receiving chemotherapy and when the hemoglobin levels are maintained below @number@ g / dL.
These products may indeed be a therapeutic option , but some can be used properly only under the guidance of a health professional.
These profiles did not differ in terms of residents ' characteristics , health problems and functional limitations.
These profiles varied in amount and type of activities.
These profiles were compared with regard to quality of life ( CarerQoL score ) , depressive symptoms ( HADS-D score ) and perseverance time.
These prognostic scores were developed in the era of chemotherpay / chemoimmunotherapy.
These programs are carried out through chemical modifications of DNA and proteins such as histones and transcription factors.
These programs are partnering to implement the Institute of Medicine's recommendations for the future of nursing.
These programs are simple , targeted , high-yield and have the potential to protect our most vulnerable patients.
These progression data and the risk factor analyses may be helpful to investigators conducting research in clinic populations.
These progressive diseases typically have an insidious onset , with overlapping clinical features early in the disease course that make diagnosis challenging.
These promise to extend our understanding of dyadic interrelations in lifespan development and aging.
These promising results have to be validated in a larger , long-term prospective trial.
These promising results suggest a deficit even for automatic and express saccades in these patients.
These proof-of-concept results provide a starting point for development of therapeutic Pin1-FOXM1 inhibitors to target metastatic melanoma.
These properties and the assumption that microRNAs act as some kind of general switch make them highly relevant in aging research.
These properties are beneficial if the sequence of is transient in manner.
These properties of miR-34a can potentially be exploited for DNA damage-effecting therapies of malignancies.
These properties of the erythrocyte are essential for the physiological functioning of the cell.
These properties were reduced more for older adults than for younger adults.
These prospective memory tasks tend to show minimal or no age-related decline.
These protective effects were particularly evident for sulfhydryl-containing ACEI ( zofenoprilat ) , which were reported to exhibit potent antioxidant effects.
These protein aggregates are thought to cause neuronal dysfunction , directly or indirectly.
These protein factors may therefore present promising therapeutic targets for the prevention of POCD.
These proteins also play an important role in maintaining neuronal health during aging.
These proteins are likely important components in understanding the function of WRN in preventing premature aging and deserve further investigation.
These proteins form a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system both in vitro and in vivo.
These proteins may be associated with abnormal protein aggregation and oxidative stress.
These proteins were specifically upregulated in tumour tissues.
These provided inputs for the GBD life table model and served as comparison observed data.
These provide interaction platforms at molecular levels linked to common hallmarks of ageing and cancer.
These provide representative benchmark data for decisions on eligibility , duration , and assessment protocols.
These provide scores and are based on the results of chronometric measurements.
The septum in the membranous stenosis was gradually extended by increasing diameter of the balloon dilator.
These purpura are frequently seen in older people due to a weakened collagen framework.
These qualitative differences clearly indicate that AD cannot be simply described as accelerated aging process but on the contrary represents a solid entity.
These qualities illustrate the serious limitations of the MMSE in detecting individual differences in cognitive function among healthy older adults.
The Sequence Kernel Association Test was used to analyze the joint effect of rare , common , or both types of variants on PD susceptibility.
The sequence motifs were significantly enriched for lysine and arginine residues near carbonylation sites ( ±10 residues ) .
The sequence of events that lead to inflammation and fibrosing nonalcoholic steatohepatitis ( NASH ) is incompletely understood.
The sequence of the beverage was randomized.
The sequence of the human genome represents our genetic blueprint.
The sequences consisted of six 1000-Hz tone bursts separated by silent intervals to establish equal tonal IOIs of @number@ ms within the sequence.
The sequences consisted of six 50-ms 1000-Hz tone bursts separated by silent intervals that were adjusted to create different timing patterns.
These questions need to be addressed before the origin of cancers can be understood.
These questions touch on an even more profound question : how can successful aging be accomplished ?
These questions urgently require answers.
These questions were addressed in two studies.
The sequestration of free pro-MMP2 and @number@ by these high-molecular-mass complexes may further contribute to reduced rates of activation of MMPs.
These ratings were compared between MMDs for all patients and for subgroups with differing functional abilities.
These ratings were compared with @number@ neuropsychological measures of word-finding / language and episodic memory.
These RBPs also associate with pathological structures in other neurodegenerative diseases , including Huntington's chorea , Creutzfeldt-Jakob disease , and Alzheimer's disease.
These reactions are interrelated and any change in folate homeostasis could affect other reactions.
These reactions can lead to protein impairment by inducing non-enzymatic post-translational modifications such as protein oxidation and crosslinking.
These reactions may contribute to the formation of lens cataracts in humans.
These reactions were associated with DNA damage.
These reactions were challenging to treat.
These reactions were evoked , in @number@ healthy young adults , via sudden unpredictable antero-posterior platform translation ( barriers deterred stepping reactions ) .
These realities should inform the debates around the construction of the continuum of care.
These receptors activate intracellular signaling pathways involved in inflammatory and stress responses of chondrocytes in OA joints.
These receptors can now be profiled on a large scale by next-generation sequencing.
These receptors initiate signal transduction pathways , which typically drive inflammation in response to microbe-associated molecular patterns ( MAMPs ) and / or DAMPs.
These recommendations are solely intended for research purposes and do not have any clinical implications at this time.
These reconstructions , deposited in NeuroMorpho.Org , have since been used by other investigators in additional research , of which we highlight representative examples.
These recurrences are associated with significant rates of emergency surgery and morbidity.
These reductions along the cerebral surface might contribute to functional deficits in self-regulation and to the persistence of these deficits over development in BN.
These reductions experienced were typically greater than the minimum detectable change statistic for the BTrackS Balance Test.
These reductions in frontal white matter integrity may contribute to reductions in processing speed.
These reductions in the expression of mitochondrial gene and transcriptional coactivators and factors were recovered by androgen replacement.
These reference data provide a basis for further research into skeletal development and the management of hormone therapies in children.
These reference data should be instrumental in interpretation of results.
These reference ranges are available for physicians and patients at www.my-cholesterol.care / .
These references may help physicians accurately assess HSA results and aid researchers in making interracial comparisons of the indices.
These referred patients were monitored for subsequent success in satisfaction with their primary care needs and their rate of recidivism to the ED.
These reflexes can also be present during eating ; however , their effects on eating function are difficult to evaluate.
These regenerative capabilities decrease with onset of metamorphosis.
These regional relationships are weakly related to amyloid burden , but are in part mediated by grey matter volumes.
These regions are not only critical nodes of the sensorimotor circuitry but also the cognitive circuitry although their volume shows a relative resilience against aging.
These regions comprise of guanine and cytosine-rich repeats , which under certain conditions can fold into G-quadruplex ( G4 ) and i-motif structures , respectively.
These regions of the cerebrum could play an important role in gait control.
These regions showed only partial overlap with areas where grey matter loss was found , making atrophy an unlikely explanation for our results.
These regulatory mechanisms were independent of acute changes of telomere length.
These regulatory systems represent the long-sought-after molecular interfaces that mediate gene × environment interactions.
These relationship patterns were found in both younger and older groups of men and women.
These relationships between phase and FA were significant in the territories limited to the middle cerebral artery as well as across the entire brain.
These relationships persist despite correcting for reporting artifacts and survival bias.
These relationships remained significant after controlling for medical conditions or psychiatric symptoms.
These relationships should be validated by a longitudinal study , with comprehensive hormone profile testing.
These relationships were incorporated into an iterative simulation to model development of a growing , bowed tibia with an initial defect angle of @number@ degrees.
These relationships were independent of HbA1c and hypoglycemic episodes.
These relationships were non-significant among the obese group.
These relationships were not observed in the younger adults , nor in the older males.
These relationships were significant even after controlling for depression status , age , education , and sex.
These relationships were weaker among elderly men.
These relative performances compared with World Record comparisons of approximately @percent@ ( with weightlifting at approximately @percent@ ) .
These remedial therapies can cause tolerance when used very early in life and , sometimes needed , repeatedly.
These remediation therapies are based on the lifelong plasticity of the human brain.
These reporter cells responded in vitro to medium conditioned by psychosine-treated oligodendrocytes , indicating the likelihood that oligodendrocytes release a TLR2 ligand during apoptosis.
These reports provide conflicting results.
These representations seem to follow what we know about the underlying functional organization of the brain and also capture some pathological processes.
These repression and induction clusters are enhanced in the brains of those with Alzheimer's , Huntington's , or Parkinson's disease.
These requests have been made by more than @number@ investigators located in @number@ US states and @number@ countries.
These requirements are mandatory to decrease patients ' mortality step by step.
These require various cognitive processes including learning , memory , and language.
These reservoirs remain present despite cART.
These residents are always bacteriuric , because of biofilm formation along the catheter , and experience increased morbidity associated with urinary tract infection.
These resources are health and education for Turkish elders , and health and age for Dutch elders.
These respondents mainly used the Internet for practical and financial purposes such as searching for information , comparing products , and banking.
These responses may broadly be considered to reflect forms of pro-social engagement , passive disengagement , and active disengagement.
These responses play an important role in carcinogenesis , neurodegeneration , and aging.
These responses synergize with defective viral clearance with aging noted by impaired IFN-α responses by plasmacytoid DCs.
These responses were not significantly different between young and elderly men , either before or after 12weeks of exercise training.
These restricted distributions may negatively affect the ability to detect a correlation when one exists.
These result from a combination of the above two processes , overlaying genetic predispositions which contribute significantly to the aging phenotype.
These results accord with previous studies suggesting that the effects of economic crises are typically first experienced through deficits in emotional well-being.
These results advance understanding of the TSH-free T₄ relationship , which is central to thyroid pathophysiology and laboratory diagnosis of thyroid disease.
These results also indicate that cell density is a significant modulator of AβPP processing.
These results also offer some support to the validity of the PMS in this patient population.
These results also suggest an evolutionarily conserved function for the FGFR-Klotho axis in metabolic regulation.
These results also suggest that POLD1 gene testing should be considered in patients presenting with severe progeroid features.
These results also suggest that reductions in metabolic cost may be a fundamental feature of motor adaptation.
These results also suggest tissue regulation of telomere size by local factors likely related to oxidative stress responses.
These results appear to support age-related compensation hypotheses.
These results are a plea for the development of appropriate preventive measures.
These results are a valuable resource from which multiple future studies may be undertaken to better understand the mechanisms that promote skin youthfulness in humans.
These results are better explained in terms of source-monitoring errors , mediated by people's retrieval expectations.
These results are comparable with results from previous studies.
These results are compatible with attentional capacity models of cognitive aging but not with current inhibitory deficit models.
These results are considered to be useful for understanding cardiodynamics surrounding meal ingestion.
These results are consistent with a reduction in neural synchrony in older adults to transient components of both speech and nonspeech sounds.
These results are consistent with computational models of executive cognition and dopamine-mediated age-related cognitive decline.
These results are consistent with human apoE4-dependent cognitive and neuro-pathologic changes , supporting the principal role of domain interaction in the pathologic effect of apoE4.
These results are consistent with increases in LDL receptors available to clear IDL and LDL from blood during PCSK9 inhibition.
These results are consistent with previous histological and biochemical findings that hippocampal neurons are specifically affected by apoE4.
These results are consistent with prior studies suggesting that older adults use a simplified speech register in response to dual-task demands.
These results are consistent with reduced prefrontal attentional control in late-life GAD.
These results are consistent with research attesting to the empirical and pragmatic strengths of this measure.
These results are consistent with the conclusion that current physical activity guidelines can support sleep quality in older adults.
These results are consistent with the hypothesis that diet-associated inflammation determines LTL.
These results are consistent with the positive effects of habitual exercise on VEF in overweight postmenopausal women.
These results are discussed in relation to experience and a possible phylogenetic influence on perception and understanding of feeding.
These results are discussed in relation to recently developed models of age-related differences in working memory.
These results are discussed in relation to the two most influential models of sequential effects and to a novel account based on repetition priming.
These results are discussed in terms of short-term experience with faces creating biases , and this rapidly changes with age.
These results are discussed in terms of the efficacy of WM training for older adults when a visuospatial modality is used.
These results are discussed in the framework of recently proposed models of neural reorganization in aging.
These results are discussed within the context of socioemotional selectivity theory.
These results are discussed with respect to possible compensatory factors that maintain listening comprehension despite impaired hearing and reduced cognitive capacities.
These results are discussed with respect to the importance of upregulated NFκB signaling known to occur frequently in MM and other cancers.
These results are in line with the notion that sequence learning involves several mechanisms and that aging affects the relative contribution of these mechanisms.
These results are interpreted as reflecting a pathway priming mechanism in the Stroop task but a control adjustment process in Simon and flanker.
These results are limited to our study population who were mostly Caucasian.
These results are not yet accurate or reliable enough to use as screening tools or isolated diagnostic tests in established disease.
These results are robust to alternative specifications of the model.
These results are similar to those obtained for human sebum.
These results are similar to those of former meta-analyses but with different methods.
These results are subsequently used to estimate the relationship between all six PBM to enable ' value-based mapping ' between measures.
These results are suggestive of greater dysfunction in processing speed with older age in patients with BD compared with a healthy comparison group.
These results are surprising because glycolysis antagonizes senescence entry but are consistent with established senescent cells entering a state of low oxidative stress.
These results are the first step in determining the causation of falls from the perspective of muscle coordination.
These results are the first to compare these @number@ specific adult age groups ' driving performance as measured by a standardized driving simulator scenario.
These results are the first to demonstrate a relationship between AD-related WM alterations and impaired cognitive-motor control.
These results can assist in future prevention efforts among senior individuals with HIV infection.
These results can be used by clinical audiologists to counsel patients regarding the use of communication strategies.
These results can help health care funders and other community organizations select appropriate and effective fall interventions that also can provide positive returns on investment.
These results can inform best practice development to promote high quality , person-directed , end-of-life care for nursing home residents.
These results can offer a way for inhibition of APL cells proliferates and produce translational medicine based on microgenomics and antisense therapy.
These results can support clinical recommendations for safe bathing transfers.
These results challenge the notion that differences in training status in young people are only evident once a maturational threshold has been exceeded.
These results confirm that age-specific agonist muscle activation profiles exist during hopping even when exercise intensities are matched on the relative scale.
These results confirm that sex is a critical factor in the relationship between cortisol and poor memory performance.
These results confirm the benefits of exercise but do not support using GM-CSF to treat walking impairment in patients with PAD.
These results confirm the experimental evidence showing acidosis has a greater effect of leading to organ failure and higher mortality with increasing age.
These results confirm the well-established effectiveness and safety profiles of vardenafil.
These results contribute to the elucidation of the causes of ARHI.
These results corroborate previous analyses of [ F-18 ] FDDNP PET imaging in clinical populations.
These results could be used to develop cost-effective interventions that reduce the burden of NCDs.
These results could be used to help select older persons who should be enrolled in fall prevention programmes.
These results could be used to strengthen advocacy efforts for improvement in pain management.
These results could be useful in clinical and experimental settings as reference values to compare with data from subjects aged over @number@ years.
These results could be useful in interventions aimed at preventing cognitive decline in high-risk individuals.
These results could contribute to clarify the molecular mechanisms that affect the imbalanced Aβ production / clearance involved in the pathogenesis of AD.
These results could have important implications for the development of future treatment strategies used in the management of at-risk patients with progressive knee OA.
These results could lead to development of novel treatments for chronic insomnia.
These results could not be obtained using chemical proteasome inhibitors that cannot be directed to specific tissues.
These results could suggest that clearance of extracellular tau proteins takes place , in part , in the periphery.
These results define the conditions for the aging and anti-aging processes in golden hamster oocytes.
These results demonstrate a previously unrecognized mechanism for cellular responses to OGG1-initiated DNA BER.
These results demonstrated how primary cells of mesenchymal origin acquired an aggressive and transformed phenotype.
These results demonstrated that ADSCs improve fibroblast function through paracrine effects.
These results demonstrated that EGCG has abilities to inhibit heat-induced collagenolytic MMP-1 production via interfering with AP-1 pathways.
These results demonstrate for the first time that TBI precipitates cognitive impairment in presymptomatic AD mice , while also confirming extracellular Aβ deposits following TBI.
These results demonstrate that aging reduces the susceptibility of co-cultured VSMCs to H₂O₂-induced apoptosis through impaired Jagged1 expression in ECs.
These results demonstrate that considering shape-related characteristics improves sensitivity to detect age-related differences in subcortical structures.
These results demonstrate that DJ-1 KO mice display progressive signs of retinal / RPE degeneration in association with higher levels of oxidative stress markers.
These results demonstrate that , during systemic viral infection , aging alters the host-pathogen interaction to overproduce IL-17 , contributing to liver injury and death.
These results demonstrate that FLDK alleviates cognitive decline and reduces Aβ burden , microglial activation , oxidative stress , and inflammation responses.
These results demonstrate that HT extends CLS by increasing MnSOD activity and decreasing age-associated mitochondrial reactive oxygen species accumulation.
These results demonstrate that hypoxia-induced activation of Notch signaling mediates HPV and the development of HPH via functional activation and up-regulation of TRPC6 channels.
These results demonstrate that longitudinal changes in circulating sphingomyelin levels are influenced by age , sex , race , lifestyle factors , and diseases.
These results demonstrate that MDMX exerts oncogenic activity via suppression of RB , and suggest that both MDM2 and MDMX could be chemotherapeutic targets.
These results demonstrate that mitochondria are aggregated by p62 , following its recruitment by Parkin in a VDAC1-independent manner.
These results demonstrate that n3-PUFA reduce mitochondrial oxidant emissions , increase postabsorptive muscle protein synthesis , and enhance anabolic responses to exercise in older adults.
These results demonstrate that nasal delivery of a combined DNA adjuvant offers an attractive possibility for protection against S. pneumoniae in the elderly.
These results demonstrate that older individuals exhibit increased multisensory integration compared with younger individuals.
These results demonstrate that PPARβ / δ promotes senescence to inhibit tumorigenesis and provide new mechanistic insights into HRAS-induced cellular senescence.
These results demonstrate that sirtinol does not affect neutrophil function and is an HNE inhibitor.
These results demonstrate that SR can protect dermal fibroblasts against UVB-induced skin aging via antioxidant effects.
These results demonstrate that tDCS-linked WM training can provide long-term benefits in maintaining cognitive training benefits and extending them to untrained tasks.
These results demonstrate that the adult brain is able to catabolize fatty acids for cellular energy production.
These results demonstrate that the sleep-cognition relationship can be observed at a within-person level of analysis.
These results demonstrate that umbilical cord extracts can serve as an attractive source of proteins for skincare and chronic wound healing products.
These results demonstrate that visual function plays an important role in the aging of inhibition and its role is moderated by cognitive load.
These results demonstrate that when separating the effect of reward from the effect of corrective feedback , PD patients do not benefit from reward.
These results demonstrate that when signals are presented in noise , sensitivity to SNR cues obscures any encoding of signal level cues.
These results demonstrate that , while significant cultural differences exist , the psychometric properties of the Reminiscence Functions Scale are adequate for the Portuguese population.
These results demonstrate the difference in the neurophysiological mechanisms of age-related changes in brain activity which are associated with the polymorphism of 5-HTTLPR.
These results demonstrate the great promise for scalp EEG spectral and complexity features as noninvasive biomarkers for detection of MCI and early AD.
These results demonstrate the increased brain efficiency in individuals with higher education level that may mitigate the impact of age on brain functional connectivity.
These results demonstrate the potential for EEG transfer entropy measures as biomarkers in identifying early MCI and AD.
These results demonstrate the power of dense genotyping in large studies to identify independent susceptibility variants.
These results demonstrate the robustness of prior findings , and extend these to a general working population.
These results demonstrate the validity of the phylogenetic conservation approach in elucidating the biological significance of alternative splicing.
These results denote that the elderly are living aging characterized by comorbidities and dependence to accomplish daily activities.
These results did not vary in analyses stratified by obesity and functional limitations.
These results do not support previous findings that high IGF-I levels are favourable for a healthy body composition in community dwelling older people.
These results draw attention to important foci for rehabilitation.
These results emphasize the importance of age-stratified risk prediction models of dementia in subjects with chronic metabolic disorders.
These results emphasize the importance of considering age and Hormonal Status in coping processes , including reactivity and recovery from stressful situations.
These results emphasize the importance of consistently defining the longevity phenotype in terms of rarity of survival for appropriate comparisons across studies.
These results establish baseline age differences in spatial strategies and suggest this may impact performance on other spatial navigation assessments.
These results extend previous findings demonstrating age-related impairments in proprioceptively guided arm movements when interhemispheric transfer is required.
These results facilitate development of future interventions to predict , prevent or slow down the progression of presbycusis.
These results facilitate the interpretation of HGS conducting using Jamar digital-type dynamometers among the older adults in Singapore.
These results for the first time reveal the quantitative and qualitative characteristics of GI tract in male Alzheimer's disease transgenic mice.
These results further our understanding of the physiological mechanisms underlying impaired thermal-cardiovascular integration in healthy ageing.
These results further suggest that estrogen receptor signaling might contribute to this effect.
These results further support the benefits of adherence to the Mediterranean diet for promoting health and longevity.
These results give insights into underlying mechanisms of increased risk for aging-related chronic diseases in the context of HIV infection.
These results have been used to identify the more accessible , flexible stretches connecting the β-strand components in PrP ( Sc ) .
These results have implications for back endurance in the primary prevention of low back pain in both young and older adults.
These results have implications for future policy and / or intervention work aimed at reducing the deleterious effects of educational disadvantage on later cognitive health.
These results have implications for midlife and aging families of children with an ASD and those who provide services to these families.
These results have implications for the design and evaluation of studies of hearing and aging.
These results have important implications for diagnosing and treating thyroid conditions.
These results have important implications for disease connectomics because they provide a baseline for evaluating network impairments in age-related neuropsychiatric disorders.
These results have important implications for furthering our understanding of aging effects in sensorimotor tasks.
These results have important implications for public policy and for the design of effective decision environments for older adults.
These results have important implications for public policy and for the design of effective interventions and decision aids.
These results have profound implications for our understanding of cellular homeostatic systems in general and of telomere length maintenance in particular.
These results help elucidate the pathological processes leading to lower cognitive function in aging.
These results help establish the measure as a valuable and practical tool for use in the field of late-life suicide prevention.
These results help target age-specific measures for the prevention of permanent work disability.
These results highlight a gene network that modulates LRO biology in a manner dependent upon the conserved protein kinase TOR complex @number@
These results highlight a general , reversible mechanism by which aging compromises mammalian stem cell activity , with widespread implications for regenerative medicine.
These results highlight associations between ARF consumption and circulating levels of antioxidants in the elderly and suggest benefits from antioxidant-rich foods during aging.
These results highlight structural and functional alterations in the hippocampal network that predict age-related changes in memory function and present potential targets for intervention.
These results highlight the importance of controlling these factors when designing a study on corneal shape.
These results highlight the importance of documenting medication use in research subjects and carefully considering what types of medications should be allowed into tDCS trials.
These results highlight the importance of the role of IQ in compensating for the aging-related memory decline.
These results highlight the need for examining different aspects of social networks for promoting well-being of older people.
These results highlight the need for other forms of exercise stress tests in order to assess the peripheral limitation of patients with PAD.
These results highlight the role of semantic self-images in well-being , and have implications for the development of therapeutic interventions for well-being in aging.
These results highlight the therapeutic importance of mGluR5 antagonists in alpha-synucleinopathies.
These results hint at the possibility that more variable MFC control may be associated with greater performance fluctuations.
These results identify a critical chaperome subnetwork that functions in aging and disease.
These results identify and characterize two novel RNA isoforms of LMNA produced through alternative splicing.
These results identify a new mechanism that may contribute to the age-related impairment of elastic properties in human skin.
These results identify novel Nrf2 activities in the pilosebaceous unit and point to a role of NRF2 in MADISH pathogenesis.
These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment.
These results implicate Ni ( ii ) exposure as a contributing factor in AAT-related pathologies.
These results imply that a signal originating from the microenvironment cooperates with NRF2 to activate Il11.
These results imply that attention capacity is important for driving.
These results imply that clinicians should consider the negative affect of geriatric patients when assessing fall risk.
These results imply that for control of an infectious agent , the time between the distant exposure and the infection event is important.
These results imply that preventing the incidence of diabetes-related comorbidities may reduce the deterioration in both levels of and rates of change in physical disability.
These results indicate a need for additional investigation of biological mechanisms linking specific fatty acids in the DNL pathway to the pathogenesis of diabetes.
These results indicate a need to re-evaluate healthy weight in persons with frailty. .
These results indicate a paradigm shift regarding the fate of E3 ligases.
These results indicate ApoE ε2 as a risk factor in FTD-3 and suggest a protective role of ε4.
These results indicate a systematic decline with age in working memory resources that can be recruited to store visual information.
These results indicated a novel stress-induced intraneuronal NLRP1 / Casp1 / Casp6 pathway.
These results indicated that adiponectin plays an important role in the HA metabolism of skin.
These results indicated that balance training allows older adults with poor balance to improve dynamic balance ability and potentially reduce risk for falls.
These results indicated that engineered MI061 retains both binding specificity and affinity of cetuximab for EGFR.
These results indicated that HSF-1 might contribute to the protective effect of this compound in Caenorhabditis elegans ageing.
These results indicated that IGF-1 overexpression enhanced cells ' osteogenic capability.
These results indicated that these novel dual-fluorescence biosensors can be applied to accurately and sensitively monitor NP toxicity.
These results indicated the ATEE , as a positive transcription regulatory element , contributes to the up-regulation of α2M during replicative senescence.
These results indicated the significance of RUNX1 for androgen-dependency and that loss of RUNX1 could be a key step for the progression of prostate cancer.
These results indicate promising advances for terror management theory in explaining ageism.
These results indicate room for improvement in the health care policy against osteoporosis.
These results indicate substantial peroxisome-related alterations in AD , which may contribute to the progression of AD pathology.
These results indicate that age-related changes in neuromuscular function are not a necessary consequence of aging.
These results indicate that aging dampens systemic and cerebral hemodynamic regulatory mechanisms , and the interrelationships between systemic and cerebral hemodynamics become weaker with age.
These results indicate that an intact Wrn protein is required for immortalization and tumorigenesis in Safb1-null mice.
These results indicate that a reduction in cortical inhibition may be an important neural adaptation in response to training in both young and older adults.
These results indicate that Aβ induces oxidative stress in cultured cells and in the mouse brain.
These results indicate that BA-based BMD values are more accurate in predicting BMD in children who have a discrepancy between their BA and chronological age.
These results indicate that Bcl-3 serves as a promising target to prevent breast tumor lung metastasis.
These results indicate that BER and NER synergistically contribute to genome maintenance in non-dividing cells.
These results indicate that biological behavior and pathogenesis of EBV sBL might be different from those of EBV sBL.
These results indicate that blood levels of Mg and Fe were correlated with anemic children aged @number@ months to @number@ years.
These results indicate that both older and younger subjects rely more on global form than local motion to discriminate the direction of point-light walkers.
These results indicate that Caspase-6 activity in CA1 could be responsible for the lower cognitive performance of aged humans.
These results indicate that CSF TauΔCasp6 levels hold promise as a novel early biomarker of AD.
These results indicate that despite multiple association signals for cognitive decline in the 19q13.32 region , inter-individual variation is likely influenced substantially by environmental factors.
These results indicate that DRAM1 regulates apoptosis by inhibiting BAX degradation.
These results indicate that DS cells exhibit a BER deficiency , which is associated with prolonged chromatin association of core BER factors.
These results indicate that endogenous VASH1 tightens the endothelial barrier and makes tumor vessels resistant to cancer metastasis.
These results indicate that EP67 induces humoral immunity in aged mice not obtainable with alum and CpG.
These results indicate that exercise-stimulated extracellular Wnts play a critical role in the regulation of satellite cells in adult and aged skeletal muscle.
These results indicate that five of the six CANTAB subtests examined did not load onto single cognitive functions.
These results indicate that FOXP1 attenuates MSC senescence by orchestrating their cell-fate switch while maintaining their replicative capacity in a dose- and age-dependent manner.
These results indicate that genetic sources influencing relational processing are a key component of the genetic architecture of broader cognitive abilities.
These results indicate that increased AA cascade and inflammatory markers could contribute to AD pathology.
These results indicate that increased participation and incentives within collegiate rowing for women vs. men contribute to sex differences in athletic performance.
These results indicate that in healthy older people , subjective sleep disturbance may be associated with glial alterations in the hippocampus.
These results indicate that MB effects may be overshadowed by anticholinergic effects in older patients.
These results indicate that miR-29b inhibits intestinal mucosal growth by repressing CDK2 translation.
These results indicate that mutations in TYROBP are not a common cause of dementia in this Turkish cohort.
These results indicate that myocardial T2 measurements are robust to these potential confounding parameters.
These results indicate that normal aging might not compromise spontaneous retrieval processes but that the ability to deactivate completed intentions is impaired.
These results indicate that older adults , even with clinically-normal hearing sensitivity , have degraded phase-locked neural representations of dynamic frequency.
These results indicate that older subjects are less able to extract relevant information from noisy displays.
These results indicate that oxidative DNA damage is differentially processed within hetero or euchromatin.
These results indicate that PPARγ-dependent upregulation of MKP-7 improves the stability of SIRT1 by inactivating JNK during inflammatory responses of LPS-activated macrophages.
These results indicate that QCT / FEA , unlike DXA / aBMD , accounted for bone differences due to sex.
These results indicate that quadriceps muscle mitochondrial function is altered in patients with COPD.
These results indicate that radiotherapy manpower requirements cannot be based on population or cancer incidence alone if current technological trends continue.
These results indicate that sensory modality plays an important role in vulnerability to distraction , but not in age-related distractibility by irrelevant spatial information.
These results indicate that sjTREC level is an effective age estimation method in Koreans.
These results indicate that small components in some , if not all , foods antagonize RAGE signaling and could exhibit beneficial effects on RAGE-related diseases.
These results indicate that SUAs do not have adverse effects on atherosclerosis contrary to previous findings for glibenclamide.
These results indicate that SVBP acts as a secretory chaperone for VASH1 and contributes to the anti-angiogenic activity of VASH1.
These results indicate that the alterations in cholesterol metabolism associated with expression of H63D-HFE may contribute to the development of AD.
These results indicate that the Angpt-Tie2 system is essential for SC integrity.
These results indicate that the anti-inflammatory effects of baicalein may be mediated through PPARγ activation.
These results indicate that the characteristic localization of p38 in older granulosa cells is induced by oxidative stress.
These results indicate that the combination of aging , sensory deprivation and CI facilitates the coupling between the auditory and the visual modality.
These results indicate that the CPP-conjugated liposomes could be effective for transdermal drug delivery of antioxidant and anti-aging therapeutics.
These results indicate that the level of glutathione is the main determinant of glycation of intracellular proteins.
These results indicate that the lipidomic signature is an optimized feature associated with animal longevity , emerging LC-FFA as a potential biomarker of longevity.
These results indicate that the peptides affected their cognate signaling pathways within the brain parenchyma.
These results indicate that there is a possible risk factor posed by CPA and OTA contamination of dry-cured hams.
These results indicate that the R. rosea extract and salidroside inhibit translation initiation.
These results indicate that touch-down and foot-off during stair ascent and descent of non-instrumented staircases can be determined with acceptable precision using segmental kinematic data.
These results indicate that VASH2 played a significant role in the EMT by modulating the TGF-β signaling.
These results indicate that whole smoke-induced oxidative stress occurs in two different kinds of cells at air-liquid interface.
These results indicate the importance of individual perceptions of health rather than just counts of chronic diseases.
These results indicate the potential antidiabetic benefits of M. oleifera ethanolic leaf extract.
These results indicate the potential antifungal prophylactic effect of ITCZ-OS for a subset of patients treated with moderate or high doses of corticosteroids.
These results indicate the potential importance of posttranscriptional regulation in modulating aging-dependent changes in humans and other species.
These results indicate the versatility of the assay method for biologically relevant oxidation of RNA.
These results indicate to the necessity of the modification of the lifestyle , taking preventive measures in diabetes , and evaluation of lipid metabolism disorders.
These results inform efforts to achieve success in the Healthy Brain Initiative 2013-2018.
These results likely represent a mix of local network disruption , compensatory reorganization , and impaired control network function.
These results may be important for understanding the aging processes , and for cosmetic treatment of aging skin.
These results may be of relevance in subjects at increased thrombotic risk prior to a surgical procedure carrying a high-bleeding risk.
These results may be useful in targeting caregiver interventions to benefit both caregivers and care recipients.
These results may have implications for the diagnosis and management of human male infertility.
These results may help to explain , at least in part , individual differences in cognitive decline in middle-aged women with dopamine-related genes.
These results may lead to a rethinking on the pathophysiology of bleeding in the setting of anticoagulation.
These results may pave the way for better anti-diabetic approaches and therefore positively impact on life expectancy of diabetic subjects.
These results may provide a new insight into the regulation of miRNAs in the developmental and aging process of the human brain.
These results may provide novel insight into sarcopenic obesity in an aging society.
These results might change the existing paradigm , which describes fibroblasts as aberrantly activated cells , to a cell with a senescence phenotype.
These results might have implications for future therapeutic trials targeting tau pathology.
These results might have implications for therapy of aging T2D patients with cardiovascular disease.
These results might help in introducing new predictors of cardiovascular morbidity in a growing population of adults after surgical repair of ToF.
These results might indicate a refinement process of the callosal connections to optimize the neuronal communication between the developing cerebral hemispheres.
These results might justify genetic testing of C9orf72 in all ALS patients.
These results might suggest a conceptual difference between unilateral and bilateral spatial processing with the latter depending on additional anatomical and functional brain resources.
These results need to be prospectively validated in the future.
These results need to be verified in different populations.
These results offer new insights into the pathophysiological mechanisms of decreased BMD in HIV-infected patients.
These results open the way to new exploration of physiological and \ "AD-like \ " aging in primates.
These results point out a link between Ca2 + -transporters , aging and neurodegeneration mediated by tau protein.
These results point to the importance of illuminating the lived experience of occupational engagement as a fruitful way of informing occupation-focussed practice.
These results point to the importance of integrating histone modifications and MyoD chromatin binding for coordinated gene activation and repression during myogenic differentiation.
These results point to the need for better evaluation of the immunogenicity of VrHB-IB in older adults.
These results point to the need to bolster overdose prevention programs and policies as the historical increase in accidental poisoning mortality appears to continue unabated.
These results point towards a meaningful association between ADHD and BD , going beyond symptomatic similarities.
These results point towards intact timing error processing up to an advanced age.
These results positively correlated with decreased P300 values and WMS-III ( WMS-III ) scores differentially across various brain loci.
These results present a further step made to bridging the gap between humans and mice in biomedical research.
These results propose that decreasing axonal load can be a factor in the unsatisfactory outcomes of cross-facial grafting in the aging population.
These results prove our concept that a series of FK228 analogs are HDAC / PI3K dual inhibitors.
These results provide a compelling example of the complex competition between molecular and cellular factors that protect against protein aggregation and those that promote it.
These results provide a compelling explanation for the clinical results and unravel a new reductive damaging mechanism in cellular processes.
These results provide a link among the Mediterranean dietary pattern , the bioactive compounds of the diet , and the fecal metabolic phenolic profile.
These results provide a promising starting point for the development of efficacious and well-tolerated furin inhibitors.
These results provide a reference value for future studies in the Chinese population.
These results provided evidence that mass spectrometric imaging can be utilized as a tool to begin to identify the molecular substructure of clinically-relevant diagnostic information.
These results provided valuable information for understanding the miRNA-mediated leaf senescence of rice , and offered an important foundation for rice breeding.
These results provide enhanced understanding of adaptive deficits in these populations , as well as demonstrate the ecological validity of laboratory measures of EF.
These results provide evidence for a more nuanced understanding of the role of negative emotions in long-term physical health.
These results provide evidence for a role of evolutionarily conserved pathways in the control of aging and disease burden in humans.
These results provide evidence for the causative relationship between the degradation of collagen and the deterioration of dentin-adhesive interface.
These results provide evidence for the importance of considering motor functioning , and foremost observed gender differences when planning for individualized treatment and rehabilitation.
These results provide evidence that WIF1 has tumor suppressing properties.
These results provide further evidence supporting the interaction between MAPT and LRRK2 genes , which increases the susceptibility to PD in Chinese individuals.
These results provide further support that α-actinin-3 deficient individuals may experience faster decline in muscle function with increasing age.
These results provide important evidence that age-related immune changes or ' dys-functions ' are organ-specific.
These results provide important new insights into the neurobiology of speech perception in aging.
These results provide insights into gerontologic-focused attitudes of graduate healthcare professional students.
These results provide new insights into aging and gender , and future platelet RNA association studies must account for age and gender.
These results provide new insights into the complex interplay between Brucella and its host.
These results provide novel information regarding sex-specific differences in mechanisms that underlie vertebral fragility.
These results provide novel insights into the metabolic alterations that occur in the early metabolic stages of HTG.
These results provide novel insights on how development of depression is differentiated by age.
These results provide some evidence for the suggested roles of IGF-I and II in regulating fat mass but not lean mass in older age.
These results provide support for the effectiveness and potential durability of SOPT among persons with MCI regardless of subtype.
These results provide support for the hypothesis that dietary trans fats are detrimental to development and aging.
These results provide tentative evidence that APOE genotype moderates the association between high blood pressure and cognitive decline in later life.
These results provide the first evidence of developmental changes in the neural processes underlying the production of novel speech sounds.
These results question the often assumed link between APOE , the blood oxygenation level dependent ( BOLD ) response , and AD risk.
These results raise a possibility that actions of transcription-coupled and base excision repair pathways lead to different outcomes at CAG tracts in vivo.
These results raise the interesting possibility that CT with genotoxic drugs preferentially target telomeres.
These results raise the possibility that mTOR inhibition may have beneficial effects on immunosenescence in the elderly.
These results reinforce how important it is for the elderly to remain active and healthy.
These results reinforce the highly polymorphic nature of human Ig V genes , and suggest that many novel alleles remain to be discovered.
These results reinforce the importance of proper pain assessment and its management as part of dementia care planning.
These results reinforce the notion of an interrelation of vascular and neurodegenerative mechanisms in cerebral aging.
These results remained essentially unchanged after exclusion of men with diabetes.
These results remained even when analyses were restricted to a subpopulation with very similar head motion across age.
These results remained largely unchanged when controlling for WM integrity.
These results replicate our previous findings with young adults and extend the finding to older adult participants.
These results represent the most up to date prevalence of self-reported sitting for the US adult population.
These results reveal a dual nature for eIF2α kinases with potential implications in the treatment with histone deacetylase inhibitors.
These results reveal a fundamental trade-off between cancer and degenerative ageing diseases that sheds light on the pronounced shift in their epidemiology during ageing.
These results reveal age-induced innate immune imbalance as underlying AMD pathogenesis.
These results reveal a novel sirtuin inhibitor binding site and mechanism , and provide a structural basis for compound improvement.
These results reveal dissociable neural mechanisms associated with distinct underlying pathology that may differentially be present in older adults and contribute to auditory processing declines.
These results revealed that developmental Pb exposure does not cause cognitive decline or change the expression of the amyloid pathway in the absence of tau.
These results revealed that WM but not GM changes partly mediated the age-related increase of IIV.
These results revealed the genetic association between SLC6A3 and hypertension , and the specific VNTR alleles of SLC6A3 may be a risk factor for hypertension.
These results reveal novel , important functions of CSB in regulating the DNA DSB repair pathway choice as well as G2 / M checkpoint activation.
These results reveal that skeletal fragility may be reduced by chronic GDF11 administration.
These results shed light on a novel mechanistic account for amygdala-hippocampal network changes and concurrent alterations in emotional episodic memory in LLD.
These results should be considered for policies dealing with prevention at the workplace and retirement.
These results should be considered in studies planning to assess vitamin K intakes in older adults.
These results should be considered in the development of programs for older adults.
These results should improve understanding of cell vulnerability in aged kidneys.
These results should open new perspectives for the development of rehabilitation programs for memory deficits.
These results should prompt research on Turkish immigrants , regarding access barriers , since they represent the largest immigrant group.
These results show dependence of life expectancy from the social status and intellectual activity.
These results showed dissociation with the self-rated clarity in both tests.
These results showed that low- and high-volume trainings have a similar adaptation time course in the muscular function of upper-body muscles.
These results show that aerobic training could increase sleep depth and continuity , during active days , in elderly men.
These results show that age effects on associative learning are independent of other cognitive processes involved in PAL.
These results show that aMCI is associated with decline in executive function and stimuli evaluation in working memory.
These results show that both theories of exchange and altruism are simultaneously relevant in the context of the marriage squeeze of contemporary rural China.
These results show that brisk walking might be a non automatic locomotor activity requiring a high-level supraspinal control.
These results show that cognitive gain from auditory perception training depends on heightened white matter integrity in the ventral attention network.
These results show that common marmosets provide a useful model for thiol redox biology of aging.
These results show that dTIEG can modulate Dpp signalling.
These results show that elderly bilinguals and monolinguals have equivalent interference control abilities , but relay on different neural substrates.
These results show that exercise can enhance speed of behavior in older drivers and should therefore be promoted.
These results show that health conditions of the liquidators became worse during the whole observation period.
These results show that heat may modify root transparency and suggest caution in using methods based on root transparency for age estimation.
These results show that HSF1 regulates JUN expression , thereby modulating AP-1 activity.
These results show that IL-17A and TNFα act in cooperation to facilitate neutrophil migration across the endothelial cell barrier.
These results show that LTα , IL-12 , and TGF-β are involved in the cross-talk between NK cells and DCs.
These results show that morning cortisol intercepts and slopes may be associated with previous days ' affect variability and levels of bedtime cortisol.
These results show that pharmacological blockade of protein prenylation reverses nuclear morphological abnormalities that occur in HGPS in vivo.
These results show that psychotropic drug use was comparatively low.
These results show that the mobility shift assay is a convenient method to analyze the redox state of PTEN in cells.
These results show the importance of individual behavior on the risk of cancer.
These results strengthen the link between LRRK2 and the innate immunity system underscoring the involvement of inflammatory pathways in the neurodegenerative process in PD.
These results strongly indicate that physicians and caregivers are ready and waiting to become more involved in clinical research.
These results strongly suggest mTOR-dependent dysregulation of the autophagic pathway in cells isolated from the glaucomatous TM.
These results strongly suggest that some dysexecutive behavioral disorders are the outward signs of an underlying impairment in socioemotional processes.
These results strongly suggest that these compounds have significant potential for the treatment of CNS diseases.
These results suggest a cause-and-effect relationship between age-related decreases in labrum thickness and increases in labrum pathology.
These results suggest a close relationship between inflammation and central vision loss in RP.
These results suggest age invariance in using rule-violation checking strategies and a smaller , but still efficient , strategy combination in older adults.
These results suggest a greater level of peripheral insulin-resistance is associated with decreased cognitive control and working memory.
These results suggest an association of SIRT1 expression with HCC development and that SIRT1 plays a role in cancer cell growth.
These results suggest a new approach to determine the biological events underlying the pathogenesis of oral keratinocyte aging.
These results suggest an insight into the relationship between hippocampal atrophy , pathology , and functional impairment.
These results suggest an intrinsic abnormality in the CD200-CD200R signaling in MDMs during aging and , especially , in PD.
These results suggest a novel and unexpected role of Exo70 in nuclear mRNA splicing , where it might signal membrane events to the splicing apparatus.
These results suggest a possible role for secreted Klotho in the exercise-induced modulation of arterial stiffness.
These results suggest a potential broader role for the peroxisome in cellular aging and the initiation of age-related degenerative disease.
These results suggest a protective role of miR-30c against diabetic nephropathy by suppressing EMT via inhibiting Snail1-TGF-β1 pathway.
These results suggest disruption of complex I function and the likely role of creatine in sustaining ATP at late stages of dysfunction in TgCRND8 mice.
These results suggested a potential inhibitory role for one or both β2AR genes.
These results suggested that APE1 might have little protective effects on p53-dependent apoptosis irrespective of DNA repair activities in aged renal proximal tubules.
These results suggested that axonal transport machinery might be impaired , and the stability of cytoskeleton might be affected by smoking.
These results suggested that , in the absence of HIF1A , AIEC were found within LC3-associated phagosomes.
These results suggested that SBGE be considered as an agent for the treatment of breast cancer.
These results suggested that silymarin is a potential hormetin for preventing aging and age-related diseases.
These results suggested that tenuigenin provides neuroprotection to dopaminergic neurons from 6-OHDA-induced damage.
These results suggested that TMEM230 mutation may not be a common genetic factor for Chinese familial and sporadic PD patients.
These results suggested the MD in the globus pallidus , underlie the association between VCDT and multiple personalities in TCI including novelty seeking.
These results suggest increased DA release from non-DA cells and deficient DA re-uptake in PD-LID.
These results suggest long-term ingestion of SSE in humans could help to improve arterial stiffness.
These results suggest nutritional supplementation provides additional benefits to mobility-limited older adults undergoing exercise training.
These results suggests that ob / ob mice are a possible model animal for telogen effluvium.
These results suggest strength relative to the body mass being accelerated distinguishes gradations in functional performance better than muscle quality healthy 50-70y women.
These results suggest that adding a reduced dose of GnRH antagonist to the COS for IUI cycles significantly improves the outcome of the procedure.
These results suggest that additional studies are needed to define the significance of MoCA scores relative to brain integrity among an older population.
These results suggest that ADP use may be influenced by nursing home characteristics other than clinical services.
These results suggest that age-dependent downregulation of CFTR in sperm leads to lowered sperm quality in old age sperm.
These results suggest that age , gender and height have independent and interacting effects on the morphology of the pharynx and larynx.
These results suggest that age introduces significant differences in upper-limb motor function.
These results suggest that age negatively affects the binaural processing of envelope and TFS at some frequencies independently of SNHL.
These results suggest that age of patients represents an independent risk factor of ED at @number@ months follow-up after TURP.
These results suggest that age-related changes in focus switching might mediate developmental changes in WMU performance.
These results suggest that age-related neuropathologies are differentially related to late life cognitive trajectories.
These results suggest that age-related valence reversals in neural activity can exist even on tasks that require only relatively automatic processing of emotional information.
These results suggest that aging and plaque score are important predictors of reduced salivary flow rate in Japanese adults.
These results suggest that aging is a relevant factor in memory for real-life eyewitness situations.
These results suggest that a larger , more extensive trial of this therapeutic program is warranted.
These results suggest that a-md-MCI patients are characterized by a brain activity profile that is closer to that observed in Alzheimer disease.
These results suggest that amyloid deposition and age increase delivery of nanoparticle-borne reagents to the brain , in therapeutically relevant amounts.
These results suggest that arterial health may be involved with the ability of the central nervous system to activate muscle in older women.
These results suggest that ART should be administered to HIV / HCV-coinfected patients to lower the risk of end-stage liver disease.
These results suggest that at lower levels of task difficulty , older and younger adults engaged similar neural networks that benefited behavioral performance.
These results suggest that attentional deficits from aging in peripheral cueing tasks may only arise as difficulty increases , such as larger set sizes.
These results suggest that audience design and social relations are worth further study in language maintenance in older age.
These results suggest that autophagy plays both a cytoprotective and death-promoting role in the pathogenesis of OA.
These results suggest that axial and bradykinetic parkinsonian signs represent risk factors for MCI but MPS may not predict conversion from MCI to AD.
These results suggest that baseline glycemia is related to cognitive decline and progression to AD.
These results suggest that bihemispheric stimulation is more effective in improving language learning but this effect is age-dependent.
These results suggest that bilateral middle and left inferior frontal regions support self-initiated semantic memory strategy use across the adult lifespan.
These results suggest that brain volumes are an important determinant of poor outcome in patients with high cardiovascular risk.
These results suggest that CaMKII in Drosophila melanogaster acts directly on heart function and that increasing CaMKII expression levels could be beneficial to improve contractility.
These results suggest that Caspase-6 is likely important in most tissues during early development but is less involved in adult tissues.
These results suggest that CD33 antagonists may be useful in reducing AD risk.
These results suggest that Celergen exerts promising chemopreventive properties to be further investigated.
These results suggest that changes in PGS mediated changes in PTS following spousal bereavement to a greater extent than vice versa.
These results suggest that CHIP can remodel the hTERT-chaperone complexes.
These results suggest that CH may reduce aging-related changes of the extracellular matrix by stimulating anabolic processes in skin tissue.
These results suggest that chronic heavy alcohol consumption may negatively impact bone health , in part , by suppressing intracortical bone remodeling.
These results suggest that chronic low-grade inflammation is not an aggravating factor of the spiraling process leading to frailty.
These results suggest that circulating miRNAs may be a biological marker of aging and could also be important for regulating longevity.
These results suggest that CW compared to NCW word pairs provide schematic support that older adults can use to improve their memory.
These results suggest that declining acuity plays an important explanatory role in age-related declines in cognitive abilities.
These results suggest that decreased BAT activity may be associated with accumulation of body fat with age.
These results suggest that DENV infection adds minimal cost to Ae. aegypti , an important finding when parameterizing the vector competence of this mosquito.
These results suggest that despite increased muscle coactivation , older adults can adapt to the novel dynamics , albeit less accurately.
These results suggest that different types of physical activity behavior may differentially impact pain inhibitory and facilitatory processes in older adults.
These results suggest that disrupted serotonergic systems predispose individuals towards aggressive behavior by increasing impulsive reactivity to negative affect.
These results suggest that DJ-1-associated Parkinsonism results from excessive protein glycation and establishes DJ-1 as a major anti-glycation and anti-aging protein.
These results suggest that DKI provides important complementary indices of brain microstructure for the study of brain aging and neurologic disease.
These results suggest that drug development should be directed toward anti-tumor agents in hematological malignancies that can help maintain and improve patients ' QOL.
These results suggest that EBNE is effective for the improvement of bone loss and skin aging in postmenopause all women.
These results suggest that elevated AOPP levels could be used to predict mortality risk in elderly patients.
These results suggest that encoding processes are impaired in older individual , which may explain age-related cognitive mapping deficits.
These results suggest that enhanced BDNF signaling during learning may itself produce the cognitive benefits afforded by prior physical or mental activity.
These results suggest that enoxaparin preserves the arterial endothelial function in a mechanism independent of its anticoagulant activity.
These results suggest that even low-fidelity driving simulators may be useful in predicting real-world outcomes.
These results suggest that event segmentation is a basic cognitive mechanism , important for memory across the lifespan.
These results suggest that exogenous auditory ERPs are enhanced in musicians , but decline with age at the same rate.
These results suggest that exposure to infectious agents should be an important consideration in future studies of telomere dynamics.
These results suggest that functional screening mediated by miRNA libraries can provide new insights into the genes essential for tamoxifen response in breast cancer.
These results suggest that genetic variation within ADAM10 , an APP processing gene , influences CSF APPα levels in an AD specific manner.
These results suggest that genetic variation within the A2M gene influences CSF Aβ ( @number@ ) levels.
These results suggest that glutamate triggers the Nox-dependent generation of extracellular H₂O₂ via ERK1 / 2 activation , which contributes to oxidative glutamate toxicity.
These results suggest that heterogeneities in the metacognition of phenomenal properties of experience are important constraints in human cognition.
These results suggest that high lipid peroxidation and decreased antioxidant defenses may be present early in cognitive disorders.
These results suggest that hnRNP protein levels can play a modulatory role on TDP-43 functions.
These results suggest that hypo-osmotic shock-induced inflammatory reactions promote hypersensitivity to pruritus in skin with disrupted barrier function.
These results suggest that IL-1β gene variation may have a role in cognitive functions in aging females as well as males.
These results suggest that improving lifestyle behaviours such as regular exercise and increased social participation could help prevent or decrease the risk of cognitive impairment.
These results suggest that increases in sympathetic activity during heat stress are not attenuated in healthy aged humans.
These results suggest that increasing the number of chews does not affect meal size in older adults.
These results suggest that individuals with LLD display enhanced aging-related molecular patterns that are associated with higher medical comorbidity and worse cognitive function.
These results suggest that interpretive bias indicates vulnerability to late-life depression , but basic cognitive abilities may have no influence in this context.
These results suggest that interventions promoting retention of cognitive function through improved diet quality would provide maximum benefit to those with relatively low SEP.
These results suggest that intraindividual variability is highly sensitive to even subtle changes in cognitive ability.
These results suggest that leptin levels are intact , but leptin signalling is impaired in AD.
These results suggest that life-long exercise is associated with favorable body composition and attenuation of the age related decline in testosterone.
These results suggest that local changes in functional integration among cortical areas supporting lexical speech production are modulated by age and task demands.
These results suggest that local white matter lesions can decrease tract-specific functional connectivity , both in direct and indirect connections.
These results suggest that lower taste and smell perception may be an indicator of frailty in old age.
These results suggest that LTL decreases with increasing age and that LTL is not related to mortality in men aged more than @number@ years.
These results suggest that maintenance of spinal alignment and back muscle strength may be important for better shoulder ROM.
These results , suggest that measurements mineral concentrations in hair are indicators of hay fever risk.
These results suggest that melatonin is an important mediator in the formation of bone tissue.
These results suggest that metabolic enzymes involved in converting capecitabine metabolites are not altered by age.
These results suggest that metabolic therapies could offer important benefits for Huntington's disease without negative behavioral or physiological consequences.
These results suggest that MHY218 may be a useful candidate to be used in the chemoprevention and / or treatment of colon cancer.
These results suggest that MHY336 is an attractive chemotherapeutic agent because of its topoisomerase II-mediated anti-tumour activity in human prostate cancer.
These results suggest that Mieap induces intramitochondrial lysosome-like organella that plays a critical role in mitochondrial quality control by eliminating oxidized mitochondrial proteins.
These results suggest that miR-378a-3p-dependent GOLT1A expression contributes to the mechanisms underlying breast cancer endocrine resistance.
These results suggest that mitochondria may actively regulate metabolic homeostasis at the cellular and organismal level via peptides encoded within their genome.
These results suggest that modified SE may be useful in the study of SBF dynamics.
These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.
These results suggest that NAR inhibited PTX-induced aging by lessening the PTX-induced oxidative stress.
These results suggest that novel AD genetic risk variants may contribute to structural brain aging in nondemented older community persons.
These results suggest that OBE exists in VWM over the life span ( 6-67 years ) , yet continues to develop along with VWM.
These results suggest that older adults have intrinsic deficits in contextual cuing that cannot be attributed to their slower overall response speed.
These results suggest that older adults ' reading strategies are not as risky as was previously claimed.
These results suggest that older adults who are already vulnerable to micronutrient inadequacies , are forgoing the nutritional advantages of vitamin-rich dairy products.
These results suggest that OTC is a potent stimulant of nSMase-2 expression and that there may be unanticipated complications of OTC supplementation.
These results suggest that parasites infecting pregnant women persist after delivery and increase the risk of malaria during the postpartum period.
These results suggest that patients with HF harbor significantly altered gut microbiota , which varies further according to age.
These results suggest that Pb causes both the overexpression of AβPP and repression of NEP resulting in the buildup of Aβ.
These results suggest that PE859 is useful for the treatment of tauopathies.
These results suggest that peripheral arterial stiffness is independently associated with perceived fatigue and fatigability in older adults.
These results suggest that perturbation of intracellular mechanisms mediated by intracellular GM1 may be a contributing factor to PD.
These results suggest that phosphorylation of MafB by JNK confers susceptibility to proteasomal degradation.
These results suggest that positive attitudes toward pressure ulcer prevention may contribute to the compliance with the guidelines in clinical practice.
These results suggest that positive childhood experiences are associated with ideal cardiovascular health in midlife.
These results suggest that postural response during manual motor imagery reverses direction with age.
These results suggest that prefrontal ageing is a manifold process demanding multifaceted models of neurocognitive ageing.
These results suggest that preventing Pin1 oxidization might help to reduce the risk of AD.
These results suggest that prevention and management of health conditions , basic ADL , and BMI may be reasonable targets for intervention.
These results suggest that protein intakes of ≥1.0 g / kg body weight / d may be optimal for maintaining physical function in older adults.
These results suggest that PSE can play a useful role in alleviating cognitive deficit induced by a cholesterol-enriched diet and ageing.
These results suggest that red light plays a key role in the antiphotoaging of human skin fibroblasts by acting on different signaling transduction pathways.
These results suggest that reduction in ADMA may play an important role in the aerobic exercise training-induced increase in arterial compliance.
These results suggest that resveratrol could be an important chemoprevention agent for hepatoma of hepatitis C virus infection.
These results suggest that rice berry has potential as an effective agent for neurodegeneration and memory impairment in Alzheimer's disease.
These results suggest that RORα could represent a direct link between local lipid metabolism of colorectal tissue and colorectal cancer.
These results suggest that sensory and motoric components of postural control are under the influence of different dynamic attentional processes.
These results suggest that SIRT1 repressed the expression of SASP factors through the deacetylation of histones in their promoter regions.
These results suggest that skin surface electrical potential may be a good indicator of the pathophysiological state of the living layer of epidermis.
These results suggest that stereotypes may be related to health-related outcomes notably through ego depletion effects.
These results suggest that systemic redox regulation is important for the longevity of SSCs.
These results suggest that task difficulty and training in noise are factors important for optimizing the effects of training among older individuals.
These results suggest that tau aggregation is an important target for therapy of dementia.
These results suggest that the ability to infer the subjectivity of preferences based on sampling information begins to emerge between @number@ months and @number@ years.
These results suggest that the aging process is a determinant of mortality , beyond the functional status of patients with bacteremic pneumococcal pneumonia.
These results suggest that the amplitude of occipital sources of resting-state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathologic aging.
These results suggest that the appropriate perioperative usage of heparin enables the standard surgical treatment of lung cancer patients with cardiovascular complications.
These results suggest that the association between smoking and AD may be complex and vary according to genotype.
These results suggest that the butyryl-CoA : acetate CoA-transferase gene is a valuable marker for gastrointestinal microbiota function.
These results suggest that the CC genotype of SOD2 is an important genetic marker of suboptimal brain aging in healthy individuals.
These results suggest that the changes in metabolite concentrations during growth can reflect the pathological condition of Pelizaeus-Merzbacher disease.
These results suggest that the consumption watercress in the diet is a powerful tool for improving health and the quality of life.
These results suggest that the effect of gas-particle partitioning of organics in the atmosphere on the toxicity of SWCNTs should be investigated further.
These results suggest that the expression of renal Klotho is modulated by phosphaturia , whereas the FGFR1 expression is regulated by FGF23.
These results suggest that the extract of T. taquetii containing the triterpenes @number@ and @number@ could be applied as anti-wrinkle ingredients in cosmetic preparations.
These results suggest that the hierarchical encoding of ongoing activity declines with age , and that such encoding may be important for memory.
These results suggest that the impact of visual impairment on speed is significant but does not change as people age.
These results suggest that the increased rate of falls among obese or older adults is not likely due to a higher risk of slip initiation.
These results suggest that the MetS group had dysfunctional HDL that enriched TG , apoC-III , CETP , and SAA without antioxidant activity.
These results suggest that the neurobiological substrates of neurocognitive functioning may change across different periods in adulthood.
These results suggest that the N-terminal PH-like domain plays a critical role in F-actin binding and F-actin-mediated activation of the cofilin-phosphatase activity of SSH1.
These results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 response to arsenic and cadmium.
These results suggest that the older visual system is less stable to unimportant information than the younger visual system.
These results suggest that the PACSLAC-II is a valid tool for assessing pain in individuals with dementia.
These results suggest that the phosphorylation of RCAN1 by Dyrk1A stimulates the formation of insoluble aggregates upon aging.
These results suggest that the PKC pathway and PDGFR / EGFR transactivation pathway play important roles in HCA2-mediated Akt activation.
These results suggest that the positive relationship between premarital cohabitation and marital instability has weakened for more recent birth and marriage cohorts.
These results suggest that the presence of MCI in PD affects activity in the prefrontal cortex and caudate nucleus as well as motor-related regions.
These results suggest that the proposed method could be an effective and promising high-throughput method for antioxidant protein identification.
These results suggest that theragnostic nanosomes may be useful for detection of early PTOA as well as for targeted delivery of interventional agents.
These results suggest that there are changes in PFC contributions to context memory at midlife.
These results suggest that there are different features of inflammatory pathology in diseases associated with abnormal α-synuclein compared with AD.
These results suggest that the reduction of oxidized hPTEN is regulated by Grx5 and Ycp4.
These results suggest that the regional neuromuscular activation within the RF muscle is affected by aging during the stair walking.
These results suggest that the sensitivity of leg stiffness to accommodate for variations in hopping frequency is likely to differ between elderly and young individuals.
These results suggest that the TUG and the 10MWT could potentially help distinguish individuals with poor neuromuscular , aerobic and cognitive flexibility performances.
These results suggest that TNF-α contributes to impaired endothelial-dependent vasodilation and arterial stiffening in estrogen-deficient postmenopausal women.
These results suggest that trauma exposure may negatively impact neurocognition.
These results suggest that TRT might have a protective effect against high-grade PCa.
These results suggest that using biomarkers of AD pathology to define case and control status may increase power in genetic association studies.
These results suggest that VAE may be effective for preventing skin photoaging accelerated by UVB radiation.
These results suggest that when large , even late-onset effects are kept at low frequency by purifying selection.
These results suggest that WM integrity and hippocampal volume influence cognitive decline independently on tasks involving processing speed and executive function independent of age.
These results suggest that WRN and DNA-PKcs may cooperatively prevent G-tail shortening in vivo.
These results suggest that young subjects have better control of preprogramed movement than middle-age or elderly subjects.
These results suggest that youth may respond to maternal criticism with increased emotional reactivity but decreased cognitive control and social cognitive processing.
These results suggest the involvement of α-Kl and FGF23 in the pathogeneses of not only aging-associated syndromes but also the complications of CKD.
These results suggest the need for further clinical trials to guide health professionals regarding the safety of prescription of this supplement.
These results suggest the participation of sFRP1 in CSC aging.
These results support a new hypothesis to answer the age-old question of why sleep is necessary.
These results support a primary amyloid-based AD process that accounts for neocortical tangles and makes the largest contribution to medial temporal tangles.
These results support a prominent genetic underpinning of LTL.
These results support a recall-based explanation of age differences in hindsight bias.
These results supported that excess fluoride exposure decreased serum T levels of male farmers with age-specificity.
These results supported the \ "valence hypothesis \ " of right hemisphere dominance in processing negative emotions.
These results support further investigation of the effects of life-long exercise intensity on cognition in later life.
These results support intending BMI as nutritional reserve in institutionalized elderly patients.
These results support literature identifying tau as a marker of cognitive control , which deteriorates in old age.
These results support that the NINL might be a valuable tool to assess age-related cognitive decline.
These results support the assessment of microbleeds on T2-weighted MRI as a possible marker of both cerebral amyloid angiopathy and hypertensive vasculopathy progression.
These results support the conditioning model of food cravings and provide guidance on how to reduce food cravings.
These results support the constructive episodic simulation hypothesis : deficits in retrieving episodic details underlie changes during memory and imagination.
These results support the critical contribution of aging-related inflammatory responses to hippocampal-dependent cognitive function and synaptic plasticity , in particular during advanced aging.
These results support the deficit hypothesis alexithymia of older age.
These results support the efficacy of an Internet-based intervention to increase walking in sedentary adults.
These results support the hypothesis that cognition is a continuum in risk.
These results support the hypothesis that fronto-subcortical disruption is associated with cognitive function only in DWMHs.
These results support the hypothesis that higher concentrations of 25OHD3 , in response to CaD supplementation , are associated with improved LDL-C.
These results support the idea that divergent thinking does not decline steadily in the elderly.
These results support the notion that dampening activated human astrocytes to maintain the redox homeostasis is vital to preserve their neuroprotective potential in the CNS.
These results support the notion that there is a relationship between ASD and dysfunction of the mirror neuron system.
These results support the potential utility of alkannins as novel anti-ageing ingredients.
These results support the proposal by Brcur and Madden ( @number@ ) and suggest that the degree of cognitive load affects age-related cognitive decline.
These results support the rodent literature indicating an age-related shift in threshold for LTP , but a relative preservation of the threshold for LTD.
These results support the use of a simple stretching program for elderly individuals in counteracting age-related decline in gait function.
These results support the use of EP67 as a potential vaccine adjuvant suited to the elderly.
These results support using a piezoelectric pedometer for measuring steps in older adults who use walking aids and who walk slowly.
These results , taken together , strongly support the antiaging properties of HP and its therapeutic rather than preventive potential against aging-related diseases.
These results therefore support the task difficulty hypothesis.
These results thus point out problems in surveying individuals suffering from dementia.
These results uncover a role for a lncRNA , HOTAIR , as a platform for protein ubiquitination.
These results underline the importance of considering PA in AD diagnosis , particularly in younger patients where medial temporal atrophy may be less conspicuous.
These results underline the importance of detecting and managing metabolic syndrome components to prevent cognitive impairment and dementia.
These results underline the importance of eye examinations in older adults to prevent disability.
These results underline the importance of muscle loading for bone mass preservation as well as indicate that a site-specific variation of bone mass is possible.
These results underline the need and the potential for better noninvasive CRC screening tests.
These results underscore previous findings implicating an association between bilingualism and preserved frontal and temporal lobe function in aging.
These results underscore the benefits of targeting self-regulatory factors in intervention programs designed to improve memory skills.
These results underscore the importance of considering the effects of rewards and threats simultaneously in commitment processes.
These results underscore the importance of involving nursing staff in the medication prescription process in a long-term care setting.
These results underscore the urgent need for the government to vigorously strengthen the management of diabetes prevention and control.
These results unveil the most minimal intracellular membrane fusion machinery.
These results uphold the current universal influenza vaccination policy , and encourage policymakers to adopt strategies to improve vaccination use.
These results validate the forward genetic approach to seed longevity and anticipate the identification of many novel determinants of this important trait.
These results were compared between lesion and remote cartilage.
These results were compared to data from @number@ cataract-free control subjects.
These results were confirmed by the internal and external validation analyses.
These results were confirmed in additional regression models using LINE-1 methylation as a continuous variable.
These results were confirmed in a neuroblastoma cell line , which demonstrated that incubation with FGF2 regulates BACE1 transcription.
These results were corroborated by immunogold labeling for Cldn10.
These results were discussed with reference to the well-being paradox.
These results were driven primarily by subjects whose blood pressure was below 140 / 90 mm Hg.
These results were essentially the same regardless of whether the diagnosis of MetS was based on the IDF or the Japanese criteria.
These results were independent from psychomotor speed.
These results were independent of the age of the interaction partner.
These results were next confirmed by Western blotting of both whole tissues and primary cells.
These results were not altered after adjustment by potential confounders.
These results were not confounded by the altered lipid status or glucose homeostasis of the offspring.
These results were obtained after adjustment for age , education , sex and a variety of medical , physical and psychosocial confounders.
These results were presented in an earlier PlosOne publication.
These results were robust to adjustment for multiple confounders and were consistent with voxel-based analyses , which also implicated right greater than left temporal regions.
These results were similar in both experimental groups.
These results were similar to those of the original UK study , apart from one factor being divided into two different factors in this study.
These results were specific to P. jirovecii and did not correlate with adenovirus.
These results were successfully replicated in an independent cohort.
These results were supported by in vitro observations on endothelial progenitor cells ( EPCs ) and endothelial cells ( ECs ) .
These results were then meta-analysed with those from two deeply imputed GWAS replication cohorts ( n = @number@ and @number@ @number@ ) .
These results will facilitate investigation of the roles of iron in disease.
These results will inform future optimization and scaling up of the program into additional community-based primary care sites.
These results will provide a useful point of reference for future developmental cognitive neuroscience research targeting both typical development and vulnerable populations.
These revelations in biological mechanisms provide the pressure points of opportunity for radical discovery and development to advance modern health care.
These reviews are meant to provide a better understanding and knowledge required to plan appropriate cancer-control and prevention strategies in the country.
These revolutionary 3D culture models of AD will contribute to accelerate the discovery of novel AD drugs.
These rheological changes were correlated with the ITA° changes , but not with the MSM extent.
The serial transverse sections were analysed using a light microscope.
The series of articles in this JGIM issue provides a number of policy-relevant recommendations for advancing geriatrics research , education and practice.
These risk-adjustment models may support improvements in quality of care through accurate hospital evaluations and inter-hospital comparisons.
These risk factors are disproportionately prevalent in regions with high organ supply.
These risk factors are modifiable through a lifestyle modification program including mild exercise and nutritional guidance.
These risk factors have consequently been used to derive risk scores for predicting the likelihood of dementia.
These risk scores may be useful in clinical practice to identify persons at risk of vitamin D deficiency.
These roles , which encompass signal , decoy , scaffold and guide capacities , derive from folded modular domains in lncRNAs.
The seroprevalence of hepatitis C virus ( HCV ) infection tends to be higher in the elderly than in younger populations.
These ROS / RNS have been shown to be critical for various biological events including signal transduction , aging , apoptosis , and development.
These routes are reviewed here in the context of sub-system proteostasis and complex adaptive systems theory.
The serovar distribution indicated that ocular chlamydial infections usually have a genital source.
These RT and variability data were related to the single-task and dual-task practice benefits.
The serum AMH level was inversely correlated with age ( r = @number@ P < @number@ ) .
The serum concentration of IL-23 in GD patients was measured significantly higher than in health controls.
The serum concentrations of FSH , LH and estradiol ( E2 ) were measured with radioimmunoassay.
The serum C-terminal cross-linking telopeptide values also gradually increased from the initial @number@ pg / mL to @number@ pg / mL at the 3-year follow-up.
The serum galactomannan ( GM ) was positive in @number@ patients.
The serum GDF-15 elevated in Mitomouse was likewise reduced by MA-5.
The serum hormone levels were studied among middle and gerontic aged residents of Arkhangelsk by enzyme immunoassay and radioimmunoassay.
The serum IgG antibody titer to Eikenella corrodens FDC1073 , Porphyromonas gingivalis SU63 , and Campylobacter rectus ATCC33238 was significantly higher in the recurrence group.
The serum level of endoglin was significantly higher ( p < @number@ ) in senescent healthy persons compared to the younger control group.
The serum level of IL-6 , not detectable in the young subjects , did not differ in the oldest and old seniors.
The serum level of SOD1 , but not SOD2 , was significantly lower in the NTG patients than in the healthy controls.
The serum levels of MMPs were determined by ELISA.
The serum levels of zinc ( S-Zn ) , copper ( S-Cu ) and high-sensitivity C-reactive protein ( hs-CRP ) were measured.
The serum level was well correlated with the progress of the breast carcinoma.
The serum renalase , dopamine , and norepinephrine concentration together with blood pressure value and echocardiography were assessed.
The serum RNase-L levels of these subjects were measured , and the association of MetS-related factors with RNase-L levels was assessed.
The serum superoxide dismutase ( SOD ) activity was detected and the effect of the moxibustion from both prevention and treatment aspects were compared.
The server provides comprehensive age-related gene information and analysis pipelines.
These same demands can prevent participation in a group.
These same variables were also associated with the progression from background to proliferative RD.
These samples collected for this study were unbalanced panel data.
These samples were analyzed for relative myosin heavy chain ( MHC ) protein expression , which is highly correlated with % muscle fiber type areas.
These samples were genotyped on Illumina OmniExpress single-nucleotide polymorphism arrays.
These samples were graded on an ordinal scale and genotyped for variants associated with synucleinopathies.
These scales allow evaluation of the key signs of ageing that cause individuals to seek cosmetic procedures.
These scales cover the spectrum of IADL and ADL challenges faced by persons in the community.
These schemes include consideration of nutrition , mental states , sleep , bathing , and physical activities , and even choosing some appropriate hobbies.
These scores continued to show improvement at the assessment done @number@ month after intervention.
These screening tools may help physicians make informed treatment decisions in daily practice.
These SCs are vital for normal growth , repair and regeneration.
These self-care activities are directed toward holistic wellness , prevention and treatment of aging effects , obtaining a sense of satisfaction , and self-realization.
These senescence-inflammatory effects also prevail within tumors , mediated by the senescent tumor cells and the senescent tumor stroma.
These sequences are perfectly conserved between viruses from three clades of VZV.
These services need to adapt their care delivery processes to meet the needs of a rising number of these complex , multimorbid and vulnerable patients.
These sex differences may contribute to the sex difference in lateral balance performance.
These share a number of factors with the nucleus but also rely on original mechanisms.
These shifts are most pronounced in groups with less-severe depression , in whom evidence of efficacy of treatment with antidepressants alone is less clear.
These should include community-based and residential care services , disability benefits and carers allowances.
These signaling pathways are conserved from simple invertebrates to mammals.
These signals exhibit consistent effects in the GERA cohort and among participants of the UK Biobank of non-British ancestry.
These significant correlations remained after adjustment for age and BMI.
These significant effects persisted after additional MV adjustment for smoking except for CRP.
These significant intraindividual differences do not translate to significant interindividual differences.
These similarities among otherwise unrelated disorders suggest that the aging process plays an active role in enabling the emergence of these diseases late in life.
These similarities may have implications for both grandmothers ' and infants ' ability to regulate interpersonal challenges within an extended-family interactional context.
These similarities , particularly in the early phases of neurodegeneration , might help identify appropriate animal model systems for studying of cell pathology.
These simulation results suggest that retest effects may not be distinguishable from effects of aging-related change and age-cohort differences in typical long-term traditional longitudinal designs.
These simulations also illustrate that the pattern of myosin loss along thick-filaments influences ensemble cross-bridge behavior and maintenance of force throughout the sarcomere.
These sites are critically analysed in terms of their underpinning rationalities to reveal the operation of a hegemonic post-positivist epistemological framework.
These sites were enriched in regulatory regions of the genome.
These sites were evaluated using @number@ blood samples and @number@ saliva samples collected from volunteers with ages ranging from @number@ to @number@ years.
These six physical function and health status measures can be easily implemented in a clinical setting.
These skills include exploring spirituality and coping strategies and engaging the patient in conversation and reflection about their legacy.
These skin images were also processed using image analysis software.
These sleep problems partly resemble core symptoms of narcolepsy , a sleep disorder caused by a general loss of the neurotransmitter hypocretin.
These small cells were strongly positive for markers of low differentiated keratinocytes , keratin-8 and @number@ and moreover also for vimentin.
These small , endogenous , transgenerationally transmitted RNAs target genes with roles in nutrition.
The SES measures included in the analysis were annual income , the household wealth , and the self-perceived economic satisfaction.
These SNPs may modify the phenotype in older adults who are more likely to develop symptoms of vitamin B12 malabsorption.
These SNPs were identified by separate research groups as risk alleles for non-Alzheimer's neurodegeneration.
These so-called ' conformational diseases ' involve diverse proteins and distinctive cellular pathologies.
These so-called ' delay-execute ' tasks are particularly troublesome for older adults , who consistently demonstrate impaired performance in this kind of laboratory task.
These so-called \ "poor-mobilizers \ " are difficult to be predicted , due to marked difference across previous heterogeneous studies.
These somatic mutations drive the expansion from a single founding cell to a detectable hematopoietic clone.
These sources of support will be increasingly inadequate as the population ages.
These sources served as input data for an ensemble modeling approach to estimate bladder , prostate , and kidney cancer mortality.
These spaces were frequently observed in advanced cataracts from India as large low-density crescents and annular rings.
These spatially independent effects of age suggest that the parallel decline observed in global GMV and CBF may not reflect spatially synchronized processes.
These spatial rearrangements in subdomains smaller than @number@ kb are accompanied with local transcriptional changes.
These species were specifically chosen based on differences in lifestyle and / or biology associated with varied levels of oxidative stress.
These spectral and temporal transformations are dependent on the physical dimensions of the head and pinna.
( These speed adjustment indices correlated with vision test scores and subscales of the Useful Field of View. )
These spherules are distinct in form , placement , and staining from the well-known calcification of the elastin layer of the aging Bruch's membrane.
These spousal interrelations were considerably larger in size than those found among random pairs of women and men from the same sample.
These SS ( A ) were also converted into age-education scaled scores using a linear regression model.
The session was performed three times per week for magnetic field and CWT groups , for @number@ weeks.
These staff provide the majority of hands-on care , but with limited training , recognition , or remuneration.
These statements are largely based on traditional ECG patterns and have not considered computerized measurements.
These statements report the results of an European Respiratory Society Task Force addressing actual diagnostic and therapeutic standards.
These stigmas can result in deleterious consequences for elderly people's mental and physical health in \ "normal \ " aging.
These strains are genetically and phenotypically quite diverse.
These strategies economized a big task by shaping decisions about who should get what and who will do what.
These strategies include probiotic and prebiotic preparations as well as targeted nutrients , designed to enrich the gut microbiota of the aging population.
These strategies might include nutritional interventions and physical exercise.
These strategies targeting osteoblastic cell functions may prove to be useful in promoting bone formation and improving bone strength in the aging population.
These strategies were mainly focused to reduce the mitochondrial dysfunction caused by oxidative stress and to retain the mitochondrial health in various diseases.
These stresses may change with time because of relaxation and water sorption in the oral environment.
These strict gender labels appear to preclude the institution of gender equal care.
These structural abnormalities result in microinfarcts and hemorrhages in the central nervous system.
These structural changes are often accompanied by reorganization of functional brain networks.
These structural changes may be one of the reasons why adverse reactions to permanent fillers occur clinically with a delay of several years.
These structural data support an in-line phosphonylation mechanism.
These structural defects are likely to contribute to gene expression changes reported in progeria and other types of laminopathies.
These structural network differences may provide the basis for changes in functional connectivity and indeed cognitive function as we grow older.
These structures are composed of fibrillized and ubiquitinated alpha-synuclein suggesting that impaired protein clearance is an important event in aggregate formation.
These structures localize within double membrane vacuoles , autophagosomes , which typically cluster in perinuclear position.
These structures , together with existing biochemical data , provide novel insights into the basic mechanism of telomere replication and length homeostasis by telomerase.
These structures were consistently colocalized with promyelocytic leukemia protein ( PML ) , an essential component of NBs , in particular when activated.
These students tended to have positive attitudes toward aging.
These studies advance our understanding of the role of BCL-2 family proteins in physiology and disease , providing unique tools for dissecting these functions.
These studies are limited , however , by the heterogeneity in study populations and a lack of standardized measurements of leg power.
These studies are usually based on self-reported hearing difficulties , which are potentially endogenous to labor supply.
These studies confirm that topical resveratrol , baicalin , and vitamin E are valuable ingredient that can be used for skin rejuvenation.
These studies consistently demonstrated reduced cardiovascular morbidity and mortality compared with no treatment.
These studies demonstrated that oxidation can generate neoantigens that the immune system will recognize.
These studies demonstrate that enhancing task performance by tDCS is paralleled by increased connectivity within functional networks.
These studies demonstrate that TrkB is an important therapeutic target in metastatic lung adenocarcinoma.
These studies emphasize the potential for bioengineered organ replacement in future regenerative therapies.
These studies enlighten the normal brain aging process and point to potential new biomarkers for cognitive function and impairment.
These studies establish that donor age is associated with an increased risk of abnormalities in iPSCs and will inform clinical development of reprogramming technology.
These studies find that the interaction between the two is subject to the critical influence of dopamine.
These studies further suggest that manipulation of miR-31 expression can be used to modulate senescence-related pathological conditions such as cancer , and the aging process.
These studies have amassed evidence for an evolutionarily conserved secretory program that regulates tissue homeostasis.
These studies have provided more insight into COX-2-mediated events.
These studies have resulted in a broader understanding of the mechanism involved in visualization of fingermarks using DFO and ninhydrin.
These studies have shown axonal degeneration to occur through a programmed pathway of injury signaling and cytoskeletal degradation.
These studies have shown that communication skills training can improve nursing aides ' communication with nursing home residents.
These studies have shown that the memory and well-being of people with MCI could be improved by such programs.
These studies have the power to establish new standards of care and prove the value of orthopaedic surgery.
These studies have uncovered numerous mechanistic differences between oocytes , embryos , and traditional model systems.
These studies have used either old / similar / new or old / new test formats.
These studies have used noise that was spatiotemporally localized on the target.
These studies highlight the complex links between aging and lipid signaling.
These studies highlight the importance of maintaining an intact ependymal cell lining throughout aging.
These studies highlight the promise of eye-tracking technology as a method to characterize subtle functional decline in MCI.
These studies identify distinct stages of astrocyte lineage development and highlight the parallels between astrocyte development and their reactive counterparts associated with injury.
These studies illustrate the differential involvement of RecQ helicases in the DSB repair process.
These studies implicate NKB and NK3R as essential elements of the human reproductive axis.
These studies include P300 abnormalities & visual motion discrimination , neuroimaging findings , telomere dynamics as well as neuropathology of related brain regions.
These studies indicate that the normal pattern of HRV is both homeostatic and biotic.
These studies investigated whether HCECs respond to this damage by upregulating their expression of oxidative stress and DNA damage-signaling genes in an age-dependent manner.
These studies provide , for the first time , the advantages of real-time monitoring of the dynamic movement of caveolin in living cells.
These studies reveal a novel mechanism of action of tPA and unveil OL as a target cell for cytokine effects of tPA in brain diseases.
These studies reveal that NF-κB activity in differentiated myofibers is sufficient to drive dysfunction of muscle regenerative cells via cell-non-autonomous mechanisms.
These studies shed light on the unique bioenergetic mechanisms within astrocytes that may contribute to the development of AD pathology.
These studies showed a significant positive correlation between lower urinary tract symptoms and erectile dysfunction.
These studies showed that adverse health events related to self-medication are relatively frequently reported.
These studies suggest that cognitive functions have moderate to high heritability in late life , with genetic influences varying for different cognitive domains.
These studies suggest that irradiation during puberty transiently increases stem cell self-renewal , which increases susceptibility to developing ER-negative breast cancer.
These studies support the notion and the rationale for future research and development of the use of coral exoskeletons as materials for drug delivery applications.
These studies support the notion that increased genomic instability due to defects in telomere biology and DNA repair contribute to the pathogenesis of lamin-related diseases.
These studies took place in Bangladesh , a country with high environmental arsenic exposure through contaminated drinking water.
These studies were aided by spectroscopic experiments on model peptides.
These studies were done two decades apart ( @number@ and @number@ ) .
These studies will further contribute to the understanding of the pathomechanism of α-dystroglycanopathy and the development of glycotherapeutics.
These studies would benefit from longitudinal measures of both telomere length and aging-related parameters.
These subjective experiences remained significant even when objective indicators such as medication use , the presence of diseases and functional capacity were taken into account.
These subjects are at greater risk of physical and cognitive decline , disability and death.
These subjects had a mean body mass index of @number@ ± @number@ kg / m².
These subjects had @number@'-overhang length distributions skewed towards shorter tails , the shortest overall telomere lengths and the highest frequencies of very short telomeres.
These subjects underwent conventional and tissue Doppler echocardiography according to the guidelines of the American Society of Echocardiography ( ASE ) .
These subjects were medical checkup participants recruited at Nagoya University Hospital with no macular disease , as confirmed by fundus photographs.
These substances have been suggested to have the ability to modulate aging-associated processes.
These subtle brain abnormalities may provide insight into illness mechanisms.
These successes of modern medicine have resulted in an increasing proportion of elderly in society.
These suggest that FD could yield a highly compact description of the structural changes and also might inform us about functional and cognitive variations.
These suggest that regional development of NFTs is correlated with decline of brain functions in aging and AD.
These super p53s may provide a clue for development of novel therapeutic targets.
These support services should partner with primary caregivers in order to best foster participation in physical leisure activity.
These surgical treatments for proximal femoral fracture will be required more than ever in response to acceleration of aging society in Japan.
These surveys were conducted in the United States in 2001-2003 and included @number@ adult participants , of whom @number@ reported a cancer history.
These symptoms disappeared completely on the following day.
These symptoms have negative consequences for family caregivers , causing stress and burden.
These symptoms , including erectile dysfunction ( ED ) , are sometimes similar to those met in the late onset hypogonadism.
These symptoms often cause considerable distress to patients and caregivers , and often contribute to institutionalization.
These synergies were confirmed in in vivo studies : the drug combinations showed the highest antimicrobial effects compared to monotherapy.
These synthetic molecules have limited concentration according to regulation concern.
These systems include antioxidants , that protect DNA , and mechanisms of DNA damage repair and tolerance.
These T2 w hypointensities are typically segmented semi-automatically , which is time consuming , associated with a high intra-rater variability and low inter-rater agreement.
These tasks can be performed using a combination of one or two executive function tasks.
These techniques have unique strengths and synergies in multimodality evaluation of the patient with cognitive decline or dementia.
These techniques will promote the study of the functional specialization of subregions of the DCN using MRI.
These technologies may address the limited access to health interventions in rural and remote regions.
These tendencies may influence reports that rely more on nonexperiential , reconstructive processes.
These terms / descriptors were combined using the logical operators available in search engines.
These tests were : Sensory Organization Test , Motor Control Test , Rhythmic Weight Shift.
These texts have had a decisive influence on both Aging Studies and Postcolonial Studies.
These texture parameters were also correlated with factors influencing skin aging such as sun exposure , age , smoking , drinking and body mass index.
These themes are detailed and their implications for practice are explored.
These themes highlighted the dynamics of caregiving across time , including current context and the ongoing process of decision-making.
These themes illuminated the complexities NPs face in managing patients with multiple comorbidities , taking multiple medications , and seeing multiple providers.
These themes illuminated the shared benefits of the practicum experience.
These theoretical principles also explain a wide range of other data on error detection and correction and generate new predictions for future test.
These theoretical processes are then related to individual differences in brain activation by means of multiple regression.
These therapies are becoming more efficacious while reducing postprocedural recovery time.
These therapies are not stopping the disease's progression , at their best they can only delay it.
These therapies have provided unique insight into the factors that drive skeletal pain and the structural decline that occurs in the aging skeleton.
These three component measurements are reproducible and linear.
These three concepts were identified using discourse analysis in a Swedish study of older people wanting in-home support services.
These three countries differ in society types based on the proportion of older adults , rate of population aging , and population size.
These three processes unfolded in varied ways , yet closely shaped-and were shaped by-the older adults ' participation in their necessary and chosen daily activities.
These three significant variables explained the majority of differences in dietary habits resulting from education.
These three techniques have all their specific advantages and shortcomings.
These timelines could be extended with satisfactory performance in annual simulation sessions involving assessment and practice in crisis management.
These time-scale-dependent glycemic fluctuations might contribute to brain atrophy and cognitive outcomes within this vulnerable population.
These tips and tools can help ensure an accurate evaluation.
The set of explanatory variables comprised a wide range of sociodemographic and care-related attributes , including patient-related results from comprehensive geriatric assessments and disease profiles.
These together help delineate the different roles of sex and gender in relation to risk vs. protective mechanisms. © @number@ Wiley Periodicals , Inc.
These tools have allowed the large number of studies that have shaped our current understanding of mitochondrial metabolism.
These topics are relevant for new policies and programs to support the aging in place of older persons in subsidized housing.
These topics complicate the assessment procedure and need consideration because they may affect the claimant's performance or symptom presentation.
These trainings are effective in improving knee extension and stabilizer muscles of the ankle joint strength.
These trajectories appear ideal for future research into dietary determinants and health outcomes.
These transcription factors share the common property of being developmentally regulated and of directing tissue-specific transcription and cell-fate decisions.
These transcripts belonged to the process of mitochondrial translational termination and the canonical pathway of Mitochondrial dysfunction , more specifically of Oxidative phosphorylation.
These transformation events impact mitochondrial number , morphology , activity , cellular metabolism , and mtDNA integrity.
These transformations also provide targets for anticancer treatment at different levels.
These transitions coincide with changes in amygdala response to social and affective stimuli.
These transitions from age-related alterations to relevant ophthalmological diseases , e. g. age-related macular degeneration and glaucoma are continuous.
These transitions involve dedicated proteins that promote coalescence and are facilitated by endo-membranes and cytoskeletal platforms.
These treatment methods can be highly effective and benefits can be long-standing.
These treatments enhance thymic output , which is a vital factor in generating favourable outcomes in clinical conditions.
These trends are consistent across countries , and apply even to populations with record-low variability in the length of life.
These trends are partly , but not entirely , explained by disadvantaged individuals ' poorer health and their greater risk of widowhood or marital dissolution.
These trends have important implications for human welfare and are of interest to policy makers.
These trends should be considered when planning diagnostic and therapeutic guidelines for OAI.
These trends suggested the identity of organelle types being detected.
These trends were most pronounced among those aged > or = 80 years.
These trials have also highlighted the major issues we need to focus on if we are to improve outcomes.
These trials showed safety and variable efficacy among patients.
These trials were compared to a previously published data set of trials conducted from @number@ to @number@
The setting is @number@ French oncogeriatric centers.
The setting was The Charles F. and Joanne Knight Alzheimer's Disease Research Center , Washington University School of Medicine in St Louis.
The setting was the reference hospital for the population area.
These two approaches performed similarly , with the Forensic approach showing a slight advantage.
These two cases extend the genotypic spectrum of PYCR1-related ARCL II.
These two competing risk analyses were used to calculate absolute risks of labor force exit among welfare state regimes in Europe.
These two conditions predominantly affect aging populations with the deterioration of the quality of life for the patients themselves and a tremendous burden to families.
These two \ "diagnoses before the illness \ " can help us in defining the challenges and the potential solutions that healthcare systems face today.
These two different disorders of the CNS affect millions of persons worldwide.
These two dimensions should therefore be considered when designing and testing preventive and therapeutic interventions.
These two factors appear to act independently of each other in a process that is independent of age.
These two factors combined have reduced the proportion of the population in the work force.
These two formulations are compared to each other and to the Fokker-Planck equation.
These two functions related to reports of more frequent use of collaboration and perceptions of spousal affiliation in a collaborative task.
These two groups were scanned with two @number@ T MRI machines.
These two instruments are indeed very different and should rather be considered as complementary.
These two isoforms show a cell-specific distribution , and their relative proportions also vary during development , aging , and in different disease states.
These two issues may partly explain the previous inconclusive findings regarding inhibitory deficits in normal aging.
These two issues were examined in the Lothian Birth Cohorts of @number@ and @number@
These two markers were concerted in a biocatalytic cascade composed of two parallel subsystems , with each of them following the activity of one marker.
These two \ "natural \ " experiments support the hypothesis that both hypo-reactive and hyper-active delirium may be caused by a reduction in cholinergic signaling.
These two opposing forces are finely orchestrated by several regulatory mechanisms , comprising both extrinsic and intrinsic factors.
These two phenomena affect pulse pressure in opposite directions and different magnitudes.
These two processes are partially independent but influence each other , as shown in the two-sleep-process auto-regulation model.
These two processes both facilitated and constrained each other and nurses ' abilities to orchestrate care.
These two subgroups did not differ significantly in other variables.
These two territories include the building where older people reside and the area immediately surrounding the building.
These two V. teres biomarkers apparently contributed to stimulate respiratory functions in keratinocytes.
These types emerged from the advertisements and from the views of the consumers themselves.
These types of crosslinks differ in terms of their mechanisms of formation and function.
These ultrastructural results were further confirmed by a statistically significant increase in the expression levels of α6-integrin the and laminin-332 , as estimated by immunohistochemistry.
These unadjusted comparisons persisted in multivariable analyses demonstrating that older age independently predicted worse operative outcomes after CRC procedures.
These undesirable effects can be minimized with avoidance of the sun , tanning salons , and smoking.
These unexpected findings revealed GRBs as first in class Nox downregulators capable to selectively reduce the increased expression and activity of Nox1 in disease conditions.
These unique multiple actions of M30 make it potentially useful as a disease modifying drug for the treatment of PD.
These unique structures are closely associated with protein inclusions containing ubiquitin as well as key components of the autophagy pathway.
These units should prioritize training actions and good practice guidelines dissemination in health care institutions with a high activity volume in this domain.
These unstable molecules can damage and destroy DNA , proteins , and membrane phospholipids.
These updated data would serve as useful reference for interpretation of endocrine and growth status and growth disorders in Chinese during peripubertal period.
These values are noted by the patient and have an individual value as well as leading to improved quality of their care.
These values decreased post treatment , but they were still higher than in controls.
These values must be compared to an adequate reference population.
These values were previously @number@ and @percent@ , respectively , on @number@ days per week therapy.
These values will be helpful when monitoring paediatric patients and in studies of perioperative coagulation in children.
These variables explained @percent@ of the variance in participation at @number@ years.
These variables mediated the association between the intervention and concerns about falling or daily activity in community-dwelling older adults.
These variables predicted mortality better than @number@ other measures , including baseline age and a 45-variable health deficit index.
These variables were aggregated to a prediction score , which achieved a prediction accuracy of @number@ for AD.
These variables were analysed with multiple logistic regression , using preferred location of care as the dependent variable.
These variables were not associated with serum C-terminal of telopeptide crosslinks in the subjects ( p > @number@ ) .
These variables were not only important themselves but also in interaction with gender , education , MMSE , and total intracranial volume.
These variables were not significantly different between LPLO and NPLO.
These variants confer distinct functionality to the RyR channel , such as altering Ca ( 2 + ) release properties or subcellular localization.
These variants show specific volumetric effects on brain structures rather than global effects across structures.
These variations may provide insights into the determinants of cognitive function in later life.
These variations were attenuated or vanished during the years after retirement.
These varied effects may be rationalized by an important , if ill-defined , contribution to protein translation or may manifest from other presently unidentified mechanisms.
These various fat types differ in the size of the adipocytes and the collagenous composition of their extracellular matrix and thus in their mechanical properties.
The seven monthly assessments provided by the two tasks also were examined for latent classes in their developmental trajectories.
The seventh report of the joint national committee on prevention , detection , evaluation , and treatment of high blood pressure.
The several-fold increases in the number of DYRK1A-positive and 3R-tau-positive neurofibrillary tangles in DS support this hypothesis.
The severe generalized lipodystrophy in this patient with progeroid features has not previously been described in other patients with MFS and FBN1 mutations.
The Severe Impairment Battery ( SIB ) was developed for the evaluation of preserved cognitive functions in these patients.
The severity and distribution of TDP-43 were assessed , and other age-related pathologies were also documented.
The severity and extension of white matter abnormalities were expressed in a computed score.
The severity and frequency of childhood obesity has increased significantly over the past three to four decades.
The severity of age spots , freckles , and hand skin discoloration were also assessed ; digital and ultraviolet photography of the hands was performed.
The severity of bone loss ranges from osteopenia to frank osteoporosis.
The severity of cognitive impairment was considered in the last group and dogs were categorised as having either mild or severe CDS.
The severity of coronary atherosclerosis was semi-quantitatively examined on cut sections.
The severity of depression as measured by CSDD decreased over @number@ months when adjusting for relevant resident variables.
The severity of diarrhea was assessed using the Vesikari severity scoring system while the HRQoL was assessed using the EQ-5D-3L.
The severity of ED , serum TT levels and other MetS components were compared between the groups.
The severity of handicap was significantly associated with the degree of hearing loss in both ears.
The severity of hearing loss is possibly associated with the degeneration of cochlear cells.
The severity of parkinsonian motor deficit was measured using unified PD rating scale ( UPDRS ) motor scores.
The severity of SMI , however , was significantly correlated with self-focused attention and depressive symptomatology.
The severity of subjective memory complaints was measured with the modified Multifactorial Memory Questionnaire.
The severity of symptoms generated depends on cerebral pain processing which is influenced by psychosocial factors.
The severity of symptoms was directly proportional to duration ( months affected ) ( R = @number@ ) .
The severity of taste disturbance had positive correlations with results from psychometry significantly.
The severity of the glabellar lines both at repose and during forced contraction was assessed by the Facial Wrinkle Scale ( FWS ) .
The severity of tremor may range from mild cases in population settings to more severe cases in treatment settings.
The severity of VC became more pronounced among those with longer transplant vintage and was in part influenced by past dialysis experience.
The severity of VC was compared to @number@ CKD stages 5-5D patients on a kidney transplant ( KT ) waiting list.
The severity of vocal deviation and the parameters of roughness , breathiness , strain , and instability were assessed using a visual analog scale.
These vesicles contain a subset of proteins , lipids and nucleic acids that are derived from the parent cell.
These visual representations were used to aid in the classification and evaluation of sarcopenia , obesity , and sarcopenic-obesity in elderly individuals.
These VNTR polymorphisms may be useful markers for paternity mapping and DNA fingerprinting.
These vulnerabilities should be the focus of intervention efforts to reduce stress and improve the emotional and psychological well-being of Mexican-origin caregivers.
These were also evident in OCT and in whole mount RPE / choroid preparations labeled with phalloidin.
These were compared for mortality ( χ ( @number@ ) test ) and for LOS ( Kruskal-Wallis test ) .
These were comprised of a total of thirteen unique protein sequences.
These were considered observational and analyzed separately.
These were determined by using the Horvath algorithm based on the methylation level of @number@ CpG sites.
These were developed at VA hospital sites that had existing strong partnerships with schools of medicine already engaged in research on aging.
These were dominated by health and to some extent by social care.
These were evaluated via simulations , and in vitro and in vivo experiments.
These were not consistently worse than those seen in rural dwellers.
These were obtained during revision procedures performed between @number@ months and @number@ years following original placement on the facial skeleton.
These were organized as per thematic groups and ranked by different authors in order of importance.
These were performing a pressure relief and propelling a manual wheelchair on level ground and up a ramp.
These were plotted as bar charts against PGC , resolved with one-way ANOVA and Kruskal-Wallis tests , then corrected for multiple comparisons.
These were preceded either immediately or at some earlier time by a backward-masked prime.
These were re-analysed and compared with cleaved caspase-3-labeled germ cells in the aging human and the spermatogenically active catfish testis.
These were run over six weeks with cognitive performance , anxiety , and life satisfaction measured before and after the intervention.
These were still evident in Parkinson's disease but not in progressive supranuclear palsy.
These were stratified by decades of age and by sex.
These were taken from within a large collection of processed human temporal bones.
These were transcribed and analyzed using an interpretive-descriptive approach.
These were undertaken in @number@ men and @number@ women.
These will be complemented with a kit containing practical tips on exercise , nutrition and oral care after each session.
These women lack the metabolic abnormalities seen in PCO syndrome.
These women may benefit from pre-surgical interventions designed to improve body image or to reduce pre-surgical emotional distress.
These women were randomly selected.
These workers may enjoy higher lifetime utility if they have no loan option because DC plans serve as commitment devices for retirement saving.
These works have repeatedly shown vaccine response to be an orchestrated process involving multiple arms of immunity most noticeable sensing and innate components.
These would provide a novel approach for anti-skin photoaging.
The sex-adjusted prevalence was @percent@ ( @percent@ CI , @date@ ) for women and @percent@ ( @percent@ CI , @date@ ) for men.
The sex- and season-specific predictors of fGCM may reflect the differential investment of males and females into reproduction and longevity.
The sex difference in internalizing / externalizing problems was found consistently across TBI groups and controls.
The sex difference in marathon performance increases with finishing place and age of the runner but whether this occurs among swimmers is unknown.
The sex difference in running time remained stable at ~18.7 ± @number@ % from @number@ to @number@ years of age.
The sex difference in swimming increased with world record place and age , but was less than for marathon running.
The sexes can respond differently to dietary restriction and altered activity of nutrient-sensing pathways , with females showing a greater plasticity for life extension.
The sex only affected the RoE.
The sex-related differential association between saccular response latency and gait speed requires further study.
The sex-specific differences in determinants of arterial stiffness may remind us of sex-specific targets for further interventional studies associated with arterial stiffness.
The sex-specific signaling and molecular pathways that putatively underlie the cross-talk between central arteries and bone are not completely understood.
The S-FNAME was also associated with age and gender.
The sgACC exhibited increased connections with cognitive control regions in healthy children and increased connections with thalamic and parietal regions in the PO-MDD group.
The sGAG optical density showed a linear correlation ( r = @number@ p < @number@ ) with the X-ray attenuation.
The SG received individualized meropenem therapy with a dosing strategy based on software developed from a meropenem population PK / PD model.
The sham group ( n = @number@ ) received only screw implantation and the controls ( n = @number@ ) underwent no surgery.
The shape of auditory filters was comparable between age groups , and thus shows intact frequency selectivity in normal aging.
The shape of flaps and function of the fingers were satisfactory after 6-12 months of follow-up.
The shape of the airway in neonates and infants has not been studied separately.
The shape of the mitral annulus and leaflets , and differences with age , have not been described by 3D echo in normal children.
The shape of the trabecular meshwork changes and there is a loss of trabecular endothelium.
The shapes of the trajectories , and the trends reshaping them , represent two inseparable aspects of the same phenomenon.
The Shapiro-Wilk test checked the normality of the distribution.
The shared apartments were cluster-randomized to the IM program or Usual Care ( UC ) .
The shared household effect was @number@ ( p < 0.02 ) .
The sharp increase in AMI mortality since @number@ is primarily attributable to population aging and the rise in AMI deaths among younger generations.
The sharp increase of the aging population has raised the pressure on the current limited medical resources in China.
The sharpness of the frequency response tuning curve at @number@ dB SPL above threshold was also significantly broader among the aged rats.
The shear modulus measurements were repeated twice during experiment @number@ to assess the inter-day reliability.
The shear pattern in the conduit artery affects the endothelium and may participate in the development and progression of atherosclerosis.
The shear stress on airway walls increased with aging and the highest shear stress was observed in the 80-year-old during inhalation.
The shear wave velocities did not differ between the inner and outer glands in any age group.
The shedding of procoagulant-rich microparticles from monocytes may accelerate the pathogenesis of atherothrombosis.
The SHG signal might be influenced by the interspaces of the collagen molecules within one collagen fibril.
The SHG volumes were analyzed by the Fast-Fourier Iterative Digital Volume Correlation ( DVC ) algorithm for the three dimensional ( 3D ) displacement field.
The shift in population demographics in many parts of the world has motivated the development of this focus issue.
The shift in the shape of the association was similar in all @number@ countries.
The shifts of COP beneath left and right legs were recorded onto a computer by using appropriate software compatible with platforms.
The SHLS is a 15-year longitudinal survey based on a nationally representative sample.
The shortage in village doctors presents a major obstacle toward the realization of China's policy of public health service equalization.
The shortage of physicians and resultant lack of access to care particularly on the rural neighbor islands of Hawaii has been well described.
The short- and long-term mortality rates for each age cohort were compared.
The short Aβ peptide is derived from the large transmembrane Aβ precursor protein ( APP ) .
The short BBS ( BBS-9 ) was formed of factor @number@
The short distance between heart and reflection point makes the reflected pressure wave returning to the heart earlier.
The shortened final 13-item FSES had good internal consistency and satisfactory criterion and convergent validity.
The shorter average intrinsic circadian period observed in women may have implications for understanding sex differences in habitual sleep duration and insomnia prevalence.
The shorter length of time in Canada of Chinese relative to whites accounted for some of the observed disparities.
The shorter wavelengths of light are known to interact with chromophores in photoreceptors and pigment epithelial cells to cause oxidative stress and severe damage.
The shortest sacral canal AP diameter was commonly located at the S2 and S3 levels in @percent@ and @percent@ of cases , respectively.
The Short Form-12 Health Survey was used to measure the population's perceived physical and mental health and additional demographic information was collected.
The short-form 8-item Parkinson's disease Questionnaire ( PDQ-8 ) was found to produce results similar to that of the PDQ-39 cross-culturally.
The short form includes a smaller set of items that might be more suitable for use in clinical practice or academic research settings.
The Short Form @number@ Health Survey ( SF-36 ) measured physical and mental health functioning.
The short-form performed relatively well compared to the full scale.
The Short Physical Performance Battery measured physical performance.
The Short Physical Performance Battery ( SPPB ) was used to differentiate between healthy and mobility limited older adults.
The Short Physical Performance Battery was conducted to assess the validity of the different protocols.
The Short Physical Performance Battery was used to assess function ( score range 0-12 ) .
The short TACI-transduced cells became larger and CD138 positive , demonstrated upregulated BLIMP1 and XBP1 mRNA , and acquired the morphology of plasma cells.
The short-term mortality rate was @percent@ in the entire cohort.
The short-time action of weightlessness and relatively weak hypergravity ( < or = 2g ) do not affect OA.
The shown trends have contributed to intergenerational discordance in the perception of familial values , which is important in addressing the psychological well-being of parents.
The shunt tube and the surrounding fibrocalcified band were removed , and the patient's torticollis resolved completely without recurrence.
The SI , before and after intervention , was significantly different for all @number@ participants ( @number@.244±0.688 versus @number@.064±0.671 ; P < 0.001 ) .
The side effect of delayed diagnosis on prognosis and the appropriate diagnostic strategy has been discussed.
The side-effect profile is minor and infrequent.
The side effects increased by adding TMZ , but the difference was not statistical significance and toxicities were well tolerated.
The side effects of both devices were pain , transient facial erythema , and scab formation.
The signaling networks that drive the aging process , associated functional deterioration , and pathologies has captured the scientific community's attention for decades.
The signaling pathway activated by WNT16 in osteoclast progenitors is noncanonical , whereas the pathway activated in osteoblasts is both canonical and noncanonical.
The signal intensity of renal cortex and medulla were measured to calculate renal corticomedullary contrast ratio.
The signals at the sites of inflammation mediate recruitment and differentiation in order to remove inflammatory inducers and promote tissue homeostasis restoration.
The signal was confirmed in a third independent Dutch cohort drawn from the Erasmus Rucphen Family study ( N = 1301 ) .
The SIGN checklist for observational studies and the Cochrane Collaboration's tool for assessing risk of bias in RCTs were applied.
The significance level utilized was @percent@ ( P < @number@ ) .
The significance of amyloid-β accumulation to these problems is unclear.
The significance of audiences ' critical awareness and understanding about the social implications of these representations is discussed.
The significance of health conditions in men and women , Maori and non-Maori in advanced age will be examined longitudinally.
The significance of hyperlipidaemia and alveolar bone height disappeared in an unadjusted model.
The significance of subjective aesthetic evaluation of the photographs was evaluated with the Mann-Whitney U-test.
The significance of these experiments with respect to longevity-related selective constraints in nature remains unclear.
The significance of these findings in the pathophysiology of muscle ageing is uncertain and warrants further investigation.
The significance of these findings is uncertain because no associations were found with any symptoms and signs of dry eye disease.
The significance of these findings may have relevance in terms of immune function , the aging process , and the pathology of carcinogenesis.
The significance of these findings will be determined in the AIBL longitudinal study of aging.
The significance of these observations to AD pathology is unknown.
The significance of translational research was emphasized in clinical sessions by physicians.
The significant age and anthropometric differences across the age groups could contribute to the endurance differences.
The significant association of PON1 activity with age , HDL-C , LDL-C , sex and IL-6 was confirmed in multivariate analysis.
The significant difference in hospitalization between rural and urban residing older Mexicans was largely accounted for by having health care coverage.
The significant differences in satisfaction from mental health occurred only for the elderly and participants aged 25-34 and 35-44.
The significant differences in these coefficients suggest the possibility of using the proposed method for the purpose of identification expertise.
The significant gene-based association between the ABCC9 gene and HS-Aging appeared to be driven by a region in which a significant haplotype-based association was found.
The significant increase of mean donor age suggested the use of kidneys from older donors.
The significantly higher level of DNA damage in Gadd45a ( - / - ) HSCs ultimately promoted B-cell leukemia in further transplanted recipient mice.
The significant P value was set at @number@
The significant relative changes per decade of age were found in the cingulum and parahippocampal gyrus FA measurements.
The significant SNP loci were further analyzed in comparing S with L and H , respectively.
The sign-rank test examined matched data on bed days , ED presentations , and unplanned hospital admissions pre- and post-CVW implementation.
The signs and symptoms of testosterone decline may occur gradually , and low testosterone levels may be misdiagnosed as other medical conditions.
The signs of physiological or premature aging were assessed by elastic skeleton changes.
The signs of typical solar elastosis damage were improved in both groups.
The silent period , H-reflex and maximum M-wave were not changed by NMES.
The silicone elastomer displays a continuous increase of rigidity along the @number@ days of storage , being the most sensitive to aging affects.
The similarity in these responses suggests that understanding how senescence is mediated can provide insight into both cancer and aging.
The similarity was further supported by single-cell RNA-sequencing analysis.
The simple correlation coefficient reached @number@ for the descending portion ( p < @number@ ) .
The simple fact that prolonged sitting is associated with a shorter life span must be repeatedly discussed with our patients.
The simple interface and ease of use were the characteristics of the applications most appreciated by patients.
The simplicity and easy handling of the described technique shows the potential application in microdiagnostic devices.
The simplicity and effectiveness of calorie restriction ( CR ) in lifespan and healthspan extension have fascinated generations searching for the Fountain of Youth.
The simplification of this complex network paves the way for the development of novel therapeutic strategies to eradicate HIV-1 infection.
The simulation also suggested the significant effect of the axial prestretch on the variation of axial stress in the pressure cycle.
The simulations suggest that differences in patients ' EQ-5D utility can account for large differences in QALYs , which could be relevant in cost-utility analyses.
The simultaneous adjustment for all SEP indicators showed that only adulthood SEP continued to be associated with IMT.
The simultaneous incubation of erythrocytes with PTX and NAR restored these variables to values similar to those of control erythrocytes.
The simultaneous use of phosphodiesterase type @number@ inhibitors ( PDE5-Is ) and TRT has recently been questioned.
The single C-terminal cleavage site is located before Ser-285.
The single group , pre- / post-test evaluation included @number@ PWMLs and @number@ care partners who participated in three Memory Club sites in Minnesota.
The single-item , subjective , seven-point Kemp Quality of Life Scale measured QOL.
The single most important predictor of inappropriate prescribing and risk of adverse drug events in older patients is the number of prescribed drugs.
The single negative finding suggests that further investigation is needed on possible impact on resident behavior.
The single nucleotide polymorphism rs2229901 was genotyped using PCR-RFLP method.
The single treatment protocol was well tolerated and recovery was similar to fractional CO₂ laser skin resurfacing alone.
The single-year incidence rate of new conditions was most different in the first @number@ years after oophorectomy but the difference attenuated thereafter.
The sinoatrial node is the primary pacemaker of the heart.
The sinoatrial node ( SAN ) is the primary pacemaker of the heart and controls heart rate throughout life.
The SIR for all cancer types in our population compared with the general population was @number@
The SIR for native kidney and thyroid cancers among our population compared with the general population was > 10.
The SIRT1 agonist resveratrol was able to prevent doxorubicin-induced heart function loss.
The SIRT1 mRNA level negatively correlated with the expression of miR-34a ( r = @number@ P = @number@ ) .
The sirtuin family of proteins consists of seven members in mammals ( SirT1-T7 ) .
The sirtuin proteins are an evolutionarily conserved family of NAD + -dependent deacetylases that regulate various cellular functions.
The sirtuins are a family of highly conserved NAD ( + ) -dependent lysine deacylases with important roles in metabolic regulation.
The sirtuins are a family of NAD ( + ) -dependent deacylases with important effects on aging , cancer , and metabolism.
The sirtuins are NAD + -dependent histone / protein deacetylases that are similar to Saccharomyces cerevisiae silent information regulator @number@ ( Sir2 ) .
The site of recurrence was comparable between groups.
The Sitting Balance Scale ( SBS ) measures sitting balance for frail older adults who are primarily nonambulatory.
The sitting position was most varied in the younger group.
The sit-to-stand test , MIP , MEP , and muscle strength were assessed before and after @number@ training sessions.
The situation , however , has been complicated by the identification that autophagy up-regulation can also occur during ageing.
The situation is further complicated by the fact of @number@ ethnic groups in the country.
The situation was similar according to education , but inequalities were not statistically significant.
The six multi-item scales had excellent internal consistency reliability ( alpha ≥0.84 ) and item-rest correlations ( ≥0.39 ) .
The Sixteen Personality Factor Questionnaire ( 16PF ) and the Maslach Burnout Inventory-Human Services Survey ( MBI-HSS ) were used to test personality and burnout.
The size and health of the neuronal cell population determines cognitive robustness in mammals.
The size and morphology of the synthesized nanocomposites were characterized by TEM / SEM techniques.
The size increase of skin epithelial cells during aging is well-known.
The size of each syllable in the target word was measured using a software program.
The size of the aging population is growing.
The size of the distal palm perforator mini-flap ranged from @number@ mm @date@ mm to @number@ mm @date@ mm.
The size of the educational difference in disability-free life expectancy varies significantly between countries.
The size of the ovum was also assessed by calculating the ooplasmic volume at the time of granulosa cell removal for IVF or ICSI.
The size of this pseudohomophone effect was larger in grade @number@ than in grade @number@ and did not differ between grades @number@ and @number@
The sizes and the depths of reshape of digital web-spaces disappeared.
The sizes and the depths of reshape of digital web-spaces were similar to normal ones.
The sizes of lymphocytes in elderly patients with pneumonia do not change comparing with the control groups.
The sizes of the nasopalatine foramen , the incisive canal and foramen , and anterior maxillary bone thickness were measured.
The skeletal characteristics are variable among individuals , and a longitudinal study is required to better understand age-related changes of the mandible.
The skeletal maturation of @number@ subjects aged between @number@ and @number@ years was determined by the Greulich and Pyle method.
The skeletal muscle mass and visceral fat area were measured in the study participants by bioelectrical impedance.
The skeletal muscle mass index ( SMI ) was assessed according to bioelectrical impedance.
The skeletal muscle mRNA expression of PGC1α and citrate synthase both declined following immobilization in both the young and elderly subjects.
The skeletal response to alcohol was determined by densitometry , microcomputed tomography and histomorphometry.
The skeletons consist almost exclusively of Portuguese nationals who died between @number@ and @number@
The skin absorption level and possible disruption to the skin by topical application of coumarins were evaluated in this study.
The skin barrier function was evaluated by noninvasive methods in human , and by the transdermal penetration of small- and large-fluorescent molecules in rat.
The skin is an indicator of overall health throughout life , and the skin's lifelong care and environment are reflected with aging.
The skin is often viewed as a static barrier that protects the body from the outside world.
The skin is situated in a position naturally exposed to diurnal environmental changes.
The skin is the body's largest organ and it is able to self-repair throughout an individual's life.
The skin is the part of the human body most vulnerable to ultraviolet ( UV ) radiation.
The skin laser Doppler flux was measured in the microvessels before and after the ingestion of L-arginine ( @number@ g ) .
The skin lesion continued for @number@ days.
The skin microrelief of the crow's feet , evaluated by optical profilometry , was performed in subjects from group @number@
The skin quality resulting from simultaneous lipofilling can be explained by improved angiogenesis due to transferred growth factors in the lipoaspirate.
The skin surface electrical potential was significantly increased after sodium dodecyl sulphate treatment , and the alteration was much more marked than that of TEWL.
The skin was scored for photoaging by physical examination , and coloration was measured by a colorimeter.
The SKT scores of memory and attention correlated significantly with almost all subtests of the WAIS-IV.
The skulls underwent anthropological exam in the search for metopism.
The skulls were photographed in normal frontalis and images were analyzed with the software AutoCAD @number@ in real scale.
The SLC25A24 SNPs affected the mRNA expression of SLC25A24 in human preadipocytes.
The sleep architecture of ANX + or DEP + / ANX + men did not differ from asymptomatic men.
The sleep stages modulate the autonomous nervous system and thereby the sleep stages are accompanied by different regulation regimes for the cardiovascular and respiratory system.
The slides did not affect the base of support , step length , step velocity and time of double support.
The slope for attention / executive function and language remained stable , while improvements were noted in memory performance.
The slope of cognitive decline after the change point is steeper among EAs than AAs.
The slope of this first component is significantly steeper in the older cohort.
The slopes and intercepts of this PreS-SS relationship did not differ between age groups , suggesting no changes in LV contractility with age.
The slopes of MF and MPF in young men were significantly higher than in young women.
The slopes of the regression lines of cartilage T1 rho values and age were compared between WB-C and NWB-C and between WB-P and LWB-P.
The slowing of information processing , a hallmark of cognitive aging , has several origins.
The small cohort demonstrated a relatively good outcome of sMTC patients to survive > 10 years.
The smaller volumes were observed in all brain regions , but were significantly smaller in gray matter than in white matter regions.
The smallest and largest differences appear to be in Southern Europe and in Eastern and Northern Europe , respectively.
The smallest number of actions concerned health promotion.
The smallest ones appear as granular depositions on intermediate filaments.
The small GTPase Rheb was originally detected as an immediate early response protein whose expression was induced by NMDA-dependent synaptic activity in the brain.
The small mammalian mitochondrial DNA ( mtDNA ) is very gene dense and encodes factors critical for oxidative phosphorylation.
The small number of participants with tenodesis , however , limited our ability to draw meaningful conclusions for this group.
The small remaining effects of being African American on performance levels likely reflect uncontrolled variation in factors like literacy and financial advantage.
The small RhoGTPase Cdc42 is mechanistically linked to aging of multiple tissues and to rejuvenation of hematopoietic stem cells in mice.
The small sample size precluded uni- / multivariate analyses to assess plausible interference from confounding factors.
The small sample sizes of some previous eQTL studies have limited their statistical power.
The small study sample precluded formal statistical analysis.
The small-world efficiency and node betweenness varied significantly and revealed a U- or inverted U-curve model tendency among three age groups.
The small-world measures of the MCI network exhibited intermediate values.
The SMART Balance Master device was used to measure posture balance.
The Smarter Safer Homes project aims to develop a platform to facilitate independent living.
The Smart Heat function reduces the necessary energy levels and thereby reduces the pain level and risks for side effects.
The SMAS intersegmental connections and the zygomatic SMAS border are preserved to retain effective points of facial tissue fixture.
The SMAS of older patients appears to be thinner and more delicate and therefore must be handled with care.
The SMBT is an inexpensive , safe , and repeatable measure of upper body power for the older adult.
The Smedlay's results were closer to the Jamar Hydraulic , though none of these three dynamometers produced comparable results to the Jamar Hydraulic.
The smoking-related interstitial lung diseases ( ILDs ) comprise several diseases that often coexist.
The SNP effects were analyzed using three models of codominant , dominant , and recessive.
The SNP in rs1011814 may be associated with severity of COPD.
The SNPs @number@ through @number@ @number@ through @number@ @number@ and @number@ through @number@ belong to distinct linkage disequilibrium blocks.
The SNPs were then tested for interaction with tumor TP53 status ( n = @number@ ) and anthracycline treatment ( n = @number@ ) .
The SOA threshold was derived by presenting a mask following the stimuli.
The so-called gerontechnologies specifically targeting older adults contain stigmatizing symbolism that might prevent them from adopting them.
The so-called «testosterone deficiency syndrome» is a blend of nonspecific symptoms typical of the physiological process of aging.
The sociability improved significantly for old-old participants playing with their peers.
The social and economic frameworks surrounding retirement planning are changing , and policy makers and researchers question whether retirement expectations have adapted.
The social environment impacts the ability of older adults to interact successfully with their community and age-in-place.
The social expectations of younger and older adults were clearly affected by a priori facial trustworthiness.
The social factors underpinning the interaction between nurses , residents ' families and doctors also influence decision making around antibiotic prescribing.
The social interaction among LTCF-residents ( @percent@ ) during PA was the strongest motivator on the interpersonal level.
The social interaction provided in this study was an important extrinsic motivator that increased the intrinsic motivation to adhere to the exergame program.
The social motivation strategies were more effective to stimulate the participants to comply with the training plan and remain on the intervention.
The Social Network Questionnaire Collaborative Research on Ageing in Europe Social Network Index ( COURAGE-SNI ) was part of the COURAGE questionnaire.
The social-oriented IG program allowed older adults to play more roles than the performance-based IG program.
The social part of supportive environment is composed of people ( family , friends , professional caregivers ) who provide help.
The social positioning and treatment of persons with dementia reflects dominant biomedical discourses of progressive and inevitable loss of insight , capacity , and personality.
The societal and individual costs of Alzheimer's disease are significant , worldwide.
The socio-cultural and economic contexts in developing countries influence the epidemiology or STIs and helps in making them an important public health priority.
The socio-demographic and health data on the first @number@ pairs of twins participating in this study are presented.
The sociodemographic profiles of different segments of the Brazilian population have been the object of multiple inter-census comparisons.
The socio-economic burden will increase as with continuous aging of our population.
The socioeconomic costs of the present high level of long-term benzodiazepine use are considerable.
The socio-emotional selectivity theory explains this positivity effect with a motivated goal shift in emotion regulation , which probably depends on available cognitive resources.
The socioemotional selectivity theory postulates that this positivity effect in memory reflects a general age-related preference for positive stimuli , subserving emotion regulation.
The SOC is an important determinant of life satisfaction of elderly people.
The SOC tended to enhance the positive association between decision authority and work ability.
The soft agar colony assay and tumor formation in nude mice assay showed no malignant alterations in TERT-HCECs.
The softer silicones , which swelled the most , had lower υ values than harder silicones.
The ' soft ' sides of these impacts were hardly mentioned.
The soft tissue status of the muscle insertions and shape of the footprints were qualitatively described.
The software , available commercially through RightCare Solutions , was adopted by the health system and remains in use after @number@ months.
The software developed used the combined T1- and T2-effects.
The software implementation finished one month ahead of schedule , and the software performed reliably.
The software program for the VSM test is distributed for free so that it can be widely used.
The soleus muscle maintained its activity at the same level as the gestation progressed.
The SOL H-reflex was measured during passive and active shortening and lengthening muscle actions in a sitting position.
The soluble Aβ accumulate intracellularly and disturb the synaptic function.
The soluble Aβ are known to be more neurotoxicthan fibrillar Aβ species.
The solution eye drops resulted in an in-situ phase change to gel-state when mixed with simulated tear fluid ( STF ) .
The solutions are framed in the sociocultural context.
The somatic affective , was related to RSA ( β = @number@ p = @number@ ) , but not the cognitive subscale.
The somatopause is accompanied by DNA and other macromolecule damage , and is characterized by a progressive decline in vitality and tissue function.
The somatotroph axis function shows a decline in the elderly ( somatopause ) .
The somatotyping was performed according to I.B. Galant-V.P. Chtetzov-B.A. Ni kitiuk scheme.
The sonographic measurements were correlated with demographic parameters.
The ( SO ) subjects seem to benefit from the \ "obesity paradox. \ "
The source of primary data was the Regional Oral Health Survey.
The source of the regenerative precursors is the skeletal muscle stem cells-the mononucleated cells closely associated with myofibers , which are known as satellite cells.
The source of this chronic inflammation is due to the repeated and progressive activation of immune cells.
The sources included MEDLINE , EMBASE and Cochrane Library from @number@ to @number@
The South African cohort consisted of randomly selected households ( n = 4030 ) across the country.
The South China and Northwestern China are two longevity regions.
The Spalt-Like Transcription Factor @number@ ( SALL4 ) oncogene plays a central function in embryo-fetal development and is absent in differentiated tissues.
The SPA technique is consistent and easy to learn.
The spatial and temporal organization of the genome has emerged as an additional level of regulation of nuclear functions.
The spatial distribution of A2E was determined using matrix-assisted laser desorption-ionization imaging mass spectrometry on both flat-mounted and transversally sectioned RPE tissue.
The spatial memory assay using the Morris water maze test was administered once to rats after a 14-week feeding.
The spatial reproduction of stimuli was provided by headphones using of an artificial head.
The spatiotemporal range yielding good direction discrimination performance was greatly reduced with age.
The SPBC ( @number@ ) is the survival probability of becoming a centenarian for those aged @number@
The Spearman correlation test was used , with significance level of @percent@.
The Spearman correlation was computed in order to investigate associations between craniofacial parameters.
The specific amount of physical activity necessary for good health remains unclear.
The specifications , price , ease-of-use , maintenance , and technology can differ greatly between devices.
The specific auditory and cognitive contributors to these problems have yet to be established.
The specific binding ratio ( SBR ) was calculated by DATview software.
The specific death-related stressor affecting cortisol varies by gender.
The specific domain of NOS2 that mediates this interaction is identified.
The specific feasibility objectives were to assess recruitment procedure , retention rates , study questionnaire administration and variability of collected data.
The specific goal is to examine the relationships between their perceptions of neighborhood conditions , level of community engagement , and their health and well-being.
The specific gravity-adjusted urinary triclosan concentrations were inversely associated with AFC ( @percent@ ; @percent@ CI , @percent@ , @percent@ ) .
The specificity and sensitivity of magnetic resonance imaging and transvaginal ultrasound remain uncertain.
The specificity and the sensitivity were @percent@ and @percent@ respectively.
The specificity of ELISA test results of RA patients showed @percent@ and @percent@ , when healthy controls or osteoarthritis patients were considered as negative.
The specificity of the model using patient characteristics was @percent@ but reached @percent@ when cognitive and gait outcomes were added.
The specificity of TRYP1 primers , however , failed as rodent DNA was amplified in some instances , giving unexpected product sizes.
The specific mechanisms underlying TEPC activation are still being investigated.
The specific neighbour was chosen probabilistically according to the cumulative payoff from all local interactions.
The specific parameters of these models are either constants or functions of age and / or accommodation.
The specific Sirt1 activator SRT1720 increases mitochondrial function in skeletal muscle , presumably by activating Sirt1.
The specific uptake ratio ( SUR ) was calculated as ( regional mean counts / reference mean counts-1 ) .
The specimens ( n = @number@ ) were submitted to accelerated aging for @number@ @number@ @number@ @number@ @number@ and @number@ cycles.
The specimens taken from the left side were analyzed by peripheral quantitative computed tomography ( pQCT ) and micro-CT.
The specimens taken from the right elbow joint were analyzed by radiography and histomorphometry.
The specimens were analyzed by radiography , micro-CT , and histological analysis.
The specimens were conditioned in distilled water at 37°C for @number@ h prior to testing.
The specimens were divided into three groups according to the donor's age.
The specimens were etched with @percent@ phosphoric acid , washed , and dried with air.
The specimens were in perfect condition because after extraction they were carefully cleaned , sterilized , identified and stored in water.
The specimens were polished depending on the polishing regimen , while the control was left untreated.
The specimens were randomly assigned into six groups ( n = @number@ ) .
The specimens were randomly divided into @number@ groups according to the aging conditions ( n = @number@ ) : @number@
The specimens were subjected to histological processing and sections were stained with Goldner's Trichrome.
The specimens were subjected to inflation testing , and the full-field displacement maps were measured by digital image correlation.
The specimens were submitted to an artificial aging chamber under ultraviolet light , during @number@ h.
The specimens were submitted to the shear bond strength ( SBS ) test using a universal testing machine ( @number@ mm / min ) .
The specimens were tested in a universal testing machine at a cross-head speed of @number@ mm / min.
The SPECT images were performed at 4-h post-injection for @number@ min , and the PET images were performed at @number@ min post-injection for @number@ min.
The spectral matters of illness , death , mourning , and widowhood inevitably culminate in an unhappy ending.
The spectrum may range from acute sunburn to chronic effects of sun damage , including elastosis and ultraviolet-induced skin cancer.
The spectrum of mutations reflect both the distinct genetic background and the heterogeneous nature of the Turkish ALS population.
The spectrum of the negative effects of UV radiation on the skin ranges from acute erythema to carcinogenesis.
The spectrum of treatment options ranges from immunomodulatory drugs ( e.g. , glucocorticosteroids ) to antibiotics to laser therapy and surgery.
The speech-language pathologist is usually the professional most involved in the evaluation and treatment.
The speed and accuracy of the nonword sequence were measured , and learning was inferred by examining performance within and between sessions.
The sperm motility test and penetration of zona-free hamster egg assay were performed for PATE1.
The spinal cord is well-protected within the spinal canal but can be impaired by degenerative alterations of the intervertebral discs and functional spinal segments.
The spinal cord showed a long hyperintense lesion between the vertebral levels C6 and L1 on T2-weighted MRI.
The spinal tumor frailty index , consisting of @number@ items , was applied to each patient.
The spine-to-back distance increased with lower vertebral level , regardless of age.
The spine-to-back distances were greatest in the lumbar area.
The SP is longer than its thickness both decreasing in the upper thorax ( by ca.
The spontaneous improvement of the calcaneal pitch with aging was not significant.
The spread of this syndrome has induced to study and try to reduce dementia modifiable risk factors.
The spring-hand system exhibits nonlinear dynamical behavior and here we characterize the dynamical behavior of the phase portraits using attractor reconstruction.
The sprouting area , normalized to controls , was highly reproducible between independent experiments.
The SPT and nasal smear eosinophil counts were performed using standard procedures.
The SPV reflects impaired upright body orientation , but has primarily been assessed in sitting position.
The Sr-AGe model can be used for dose assessment in epidemiological studies of general populations exposed to ingested strontium radioisotopes.
The Sr-AGe model has a similar structure to the ICRP model for the alkaline earth elements.
The SR-fiber angle was larger in the young for both motion types but this difference was not statistically significant.
The SRHDI and FI were moderately correlated ( r = 0.49 ) and both predicted mortality.
The SR test was performed on @number@ white subjects ( @number@ males ) .
The SSE-supplemented group also showed a trend towards a lower autoantibody titer at @number@ weeks from baseline.
The SSI was significantly higher ( p ≤ @number@ ) in the controls than in the fallers in all three walking conditions.
The SSI was significantly ( p < 0.0001 ) lower for both the controls and the fallers during obstacle walking compared with baseline walking.
The SSP enabled real-time monitoring of LC-MRM-MS performance during assay development and implementation , facilitating early detection and correction of chromatographic and instrumental problems.
The SSQ was administered using an interview method and / or it was self-administered and then returned by mail.
The stability in gene expression profiles was confirmed by reverse transcription quantitative PCR analysis.
The stability of CP11 was evaluated at pH @number@ @number@ in simulated fluids with different concentrations of enzymes , and in human plasma.
The stability of mammalian telomeres depends upon TRF2 , which prevents inappropriate repair and checkpoint activation.
The stability of SOD1 activity was further tested through in vitro incubation with H2O2 and scanning of its electrophoretic profiles.
The stability of the proteome is crucial to the health of the cell , and contributes significantly to the lifespan of the organism.
The stable lentiviral overexpression of GLI1 reversed the DNA double strand breaks ( DSBs ) caused by the GANT61 and TMZ.
The stable normal group showed an initial practice effect in all domains which was sustained in memory and visuospatial reasoning.
The stage of the disease was assessed after gynecological examination using POP-Q score.
The stages of AMD were graded according to the Minnesota Grading System.
The staggering complexity of HDL demands significantly more investigation before we can truly begin to understand HDL metabolism and function in humans.
The standard approach for chondrogenic induction by micromass pellet culture is highly susceptible to interdonor variability.
The standard calibration curve was linear with a correlation coefficient ( R ( @number@ ) ) of @number@ for both menadione and MK-2.
The standard deviation ( SD ) values of COP and SampEn in the sagittal and frontal planes were calculated using time series data.
The standardized glucose uptake values of several brain regions relative to the cerebellum ( SUVR ) were measured from partial volume corrected FDG-PET images.
The standardized mean difference ( Cohen's d ) was used as the effect size measure in meta-analytic calculations.
The standardized World Health Organization QoL BREF scale was used to assess the women's quality of life.
The standard JPM and the proposed method were compared through a validation study.
The standard of care for elderly GBM patients remains controversial.
The standard of care for ovarian cancer is maximal de-bulking surgery followed by adjuvant platinum-based chemotherapy.
The standard of care of glioblastoma in elderly patients remains controversial.
The standards of evaluating ROB in primary studies were evaluated by using a 14-item checklist based on the Cochrane approach for evaluating ROB.
The standard treatment for non-muscle invasive bladder cancer ( NMIBC ) is monopolar transurethral resection using resection loops ( TURB ) .
The standard use of low molecular-weight heparin caused no incidence of thromboembolic disease.
The standard weight was @number@ g , whereas the test weights ranged from @number@ to @number@ g.
The standing groups also did a fourth session in a seated condition.
The star excursion balance test could be a sensitive measure of physical performance for fall risk assessment in older people.
The StAR protein predominantly regulates steroid biosynthesis in steroidogenic tissues.
The starting constructs are GFP negative as the GFP gene is inactivated by an additional exon , or by mutations.
The starting period suggests that the association may be due to lifestyle changes , such as retirement , or to acceleration of the aging processes.
The starting points for these pathways are different risk factors or aortic ageing but they conclude in the same way : end-stage heart disease.
The start-up time was slower when pushing a stroller or pulling a shopping cart but remained unaffected by carrying shopping bags.
The STATA software statistical package was used for data analysis , and logistic regression was conducted to determine whether variables were associated with PDDIs.
The STATA ( version @number@ ) was applied to process the dose-response meta-analysis.
The state educational requirements and training requirements for administrators ' licensure may represent an additional means of influencing the quality of care in nursing homes.
The statements are based on a systematic review of the literature and a systematic two-step decision process.
The state of activity was defined according to whether they could perform activities of daily life ( ADL ) .
The state of preservation is good and more detailed antemortem information is presently being collected.
The state of the current literature reveals a need for further clinical research on the impact of cochlear implantation on cognition in older adults.
The state of the prostate gland and the lower urinary tract was monitored using questionnaires I-PSS , OAB Awareness Tool , uroflowmetry and voiding diaries.
The statistical analyses with clinical variables also showed that it was sensitive in detecting subtle shape changes of hippocampus.
The statistical analysis has showed significant difference in Ni level between endodontic and control groups ( P < @number@ ) .
The statistical analysis , however , showed no significant differences in costs either in primary care or in hospital care between @number@ and @number@
The statistical analysis of force at fracture data was performed using two-way ANOVA , with the level of significance chosen at @number@
The statistical analysis of the data was conducted using paired t-test , Fisher's exact test and χ ( @number@ ) .
The statistical analysis revealed that children whose callosal isthmus increased in thickness over the course of @number@ years showed a decrease in interhemispheric information transfer.
The statistical analysis was adjusted for hospital and for risk factors.
The statistical analysis was intent-to-treat by a logistic mixed effects model adjusted for balancing factors.
The statistical analysis was performed using SPSS , version @number@ for Windows.
The statistical analysis was performed with the SPSS statistical package , using a logistic regression model.
The statistical analysis was three-stage , including nominal stepwise regressions.
The statistically significant differences in the mutual dependence between x and y components between the groups of patients were analyzed using MANOVA.
The statistical program SPSS15.0 was used for the analysis of the data.
The statistical robustness of the observed relationships and the discriminative power of the model were verified with the cross-validation method.
The statistical significance of the observed differences was established by using an SCR-related effect size indicator ( i.e. Taunovlap ) .
The statistical significance was set at P < 0.05 and false discovery rate ( FDR ) was used to correct for multiple comparisons.
The statistics used took into account the lack of statistical independence of twin sisters.
The steadily increasing obesity epidemic affects currently @percent@ of western populations and is causative for numerous disorders.
The steady state was disturbed by doubling the number of people needing LTC over the 30-year simulation time.
The steep decline in both natural fertility and success after assisted reproduction treatment with increasing maternal age is universally recognized.
The stem cells are regulated by communication with their specialized microenvironment known as the niche.
The stem cells thanks to their ability of unlimited division number or transformation into different cell types creating organs , are responsible for regeneration processes.
The step-by-step implementation method proved efficacious.
The step-forward position used during the examination influenced the sagittal tibiofemoral angle only.
The step length and foot clearance height were significantly different between groups I and II.
The STEP model demonstrated consistent positive practice effects , negative interval effects , and predicted covariate effects.
The stepping game comprised rapid stepping , attention , and response inhibition.
The steps in the analysis were visualized by using funnel plots.
The steps were cued by either metronome beeps or visual stepping stones projected on a treadmill.
The step-to-step and walking variability of the spatial-temporal parameters ( acquiring with GAITRite® ) of the four steps before obstacle avoidance were analyzed.
The stereoselectivity of BChE is an important parameter for its efficiency at scavenging the most toxic OPs enantiomer for AChE.
The stiffness of HDFs from passages 5-20 was assessed by atomic force microscopy.
The stimulation did not elicit changes in other outcomes.
The stimuli for the recognition session consisted of learned words and novel words.
The stimulus characteristics of AoA were manipulated using a pure-list technique.
The stimulus distances were presented within a @number@ m × @number@ m portion of a grassy field.
The stimulus sequences contained two-six tone bursts , separated equally by silent intervals , with tonal IOIs ranging from @number@ to @number@ ms.
The STISIM Drive M100 driving simulator was used to assess driving parameters.
The strain of bacteria most commonly tested was Bifidobacterium longum.
The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing ( EIP on AHA ) proposed six Action Groups.
The strategies for the treatment of late onset hypogonadism ( LOH ) have focused on replacement with exogenous testosterone versus restoration of endogenous production.
The stratum corneum cytokines were harvested by sequential tape stripping and quantified by multiplex bead array and enzyme-linked immunosorbent assay.
The stratum corneum ( SC ) provides a permeability barrier that limits the inflow and outflow of water.
The strength and quality of the evidence was moderate ( six studies with level II intervention evidence , five with positive quality ) .
The strength of each recommendation and the quality of the evidence are presented in the summary.
The strength of five muscle groups was measured.
The strength of semantic association among list items was manipulated.
The strength of the association between age and SOS decreased after adjusting for IGF-1 level but it remained significant ( p < @number@ ) .
The strength of the associations was essentially equal in men and women.
The strength of the associations was stronger in the white subgroup.
The strength of the correlations decreased with increasing age.
The strength of the reciprocal associations between frailty and depression was assessed through odds ratios ( ORs ) adjusted for potential confounders.
The strength of the relationship between age stereotypes and life satisfaction increased with participants ' age.
The strength of the relationship between changes in SkM HSP70 and insulin remained unchanged after adjustment for all covariates.
The strength of this local association was comparable in the young and the elderly and in males and females.
The strengths of the associations were compared using standardized beta ( β ) coefficients.
The strength training has been shown to be effective for attenuating the age-related physiological decline.
The stresses at the end plates , discs , facet joints , and the points of contact were calculated.
The stress intensity factors ( K ( Ic ) ) were calculated by the formula reported by Atkinson et al.
The stress of different origin increases the serum cytokine levels and disrupts BBB.
The stress response elicited by preincubation with CS conferred a cytoprotective action against a following oxidant challenge with tert-butyl hydroperoxide , confirming its hormetic effect.
The stretching-induced impairments in strength and activation in the young but not the old men may suggest that the neural impairments following stretching are gamma-loop-mediated.
The striatal binding potential of non-displaceable [ ( @number@ ) I ] PE2I was calculated.
The striatum and medial temporal lobe play important roles in implicit and explicit memory , respectively.
The striatum and thalamus are subcortical structures intimately involved in addiction.
The striatum contributes to socio-cognitive functions by receiving glutamatergic inputs from the cerebral cortices.
The stricter impairment threshold of @number@.5-SD resulted in fewer patients classified as having any of the three domain-specific subtypes.
The stride length - cadence relationship ( SLCrel ) was investigated to explore a theory of two alternate but inter-related pathways for gait control.
The strips were fixed in an organ bath , and carbachol or KCl-induced isometric contractions were measured by force transducers.
The stroke is one of the most disabling neurological diseases , becoming a public health problem.
The stroke susceptibility assessment based on the analysis of human movements is one of the potential avenues needing investigation.
The strong construct of physical performance measures also makes them particularly suitable for the assessment of the frailty status.
The strong correlation with decreasing cognitive performance supports the pathophysiologic role of reduced functional connectivity in cognitive decline and the development of dementia in PD.
The stronger association found between particle number concentration and mortality in the warmer season ( @percent@ increase ) became null after adjustment for other pollutants.
The stronger association in older individuals may be due to relatively longer duration of calcium supplementation in older individuals.
The stronger , faster reacting and faster walking young subjects recovered more often by an elevating strategy than elderly subjects.
The strongest association observed was for the 4-hour moving average ( @percent@ ; @percent@ PI : @percent@ , @percent@ ) .
The strongest associations were observed with the 7-day moving averages for PM2.5 and black carbon and with the 48-hour moving averages for organic carbon.
The strongest association was between the CDT and executive functions , followed by global cognitive status , visuospatial processing , and semantic knowledge.
The strongest association was with rs976683 ( P = 1.4×10 ( @number@ ) ) .
The strongest correlation ( Wald = @number@ P = @number@ ) was observed between lower PRL levels and reduced enjoyment of orgasmic experiences.
The strongest effect modification was observed for vocabulary knowledge : high scores were generally protective but not at high levels of CRP.
The strongest factors associated with depressive symptoms were younger age , ADL impairment , and previous depression.
The strongest predictors were age and prior disability.
The strongest relationships concerned the temporal lobe cortex and hippocampus.
The strongest relationship suggests that consuming low-GI foods prevents diabetic complications.
The strongest risk factor for brain degeneration , whether it results from vascular or neurodegenerative mechanisms or both , is age.
The strongest volume reduction with age was observed in these clusters.
The strong exception was the resin containing DMAEMA that did not show dark and yellow shifts.
The Stroop effect was significantly larger in elderly participants in the inhibition trials of the switching condition.
The Stroop interference task is a widely used paradigm to examine cognitive inhibition , which is a key component of goal-directed behavior.
The Stroop task was adopted to measure inhibition.
The Stroop test is a psychological tool used to measure cognition.
The structural analysis showed no significant changes in the density of gray and white matter in ziprasidone-treated patients compared to patients receiving other antipsychotic treatments.
The structural and physiological changes demonstrated senile lung , not emphysema , without alveolar wall destruction.
The structural \ "biological \ " elasticity of the skin decreased significantly at the upper back after loading , but remained unchanged at the heels.
The structural complexity of ventricular structures was not more strongly related to age than volume.
The structural compliance of the aortic root has a significant implication for valve procedures such as transcatheter aortic valve implantation and valve-sparing aortic root replacement.
The structural equation modeling revealed that impaired sensorimotor function was the only factor influencing impaired stepping performances in the standard condition.
The structural equation modelling method was used to evaluate the suitability of the stress process model and to test the hypotheses.
The structural stability of the value circle over age was largely confirmed across and within individuals.
The structure and function of Pen-2 in vitro have been well defined.
The structure and organisation of the health service , and each worker's contact with the elderly , must preserve their dignity.
The structure of As-MIF and hJAB1 interaction was modeled by homology modeling based on the structure of Ace-MIF.
The structure of chromatin is basically maintained from yeast to human.
The structure of fat cells was altered in shape and a modification of the fibrous tract was also detected in the fat layer.
The structure of mortality of patients under dispensary supervision is characterized by the considerable prevalence of conditions that are potentially avertible.
The structure of the eye and the currently available methods of ophthalmic surgery enable the development work on stem cell transplantations and their clinical implementation.
The structure revealed a possible biologically important homo-dimeric interface similar to that formed by the hetero-dimeric complex , CAD / ICAD.
The structures delimiting these compartments help shape the face , are involved in aging , and are encountered during surgical procedures.
The structures of these isolates were elucidated by means of spectroscopic data interpretation.
The structure was determined on the basis of 1D and 2D NMR spectroscopic data.
The students demonstrated a significant increase in their self-efficacy for research.
The students ( n = @number@ response rate @percent@ ) reported high on all EBP activities.
The students reported significantly higher on formulate questions and appraise research reports than the health professionals.
The Student t-test was used to assess any differences in the mean DMFT score between genders.
The studied associations were adjusted by age group-specific smoking prevalence and seasonal fluctuations of disease-specific respiratory deaths.
The studied compartments were identified by methylene blue injection and were weighed.
The studies are especially focused on behavioral and cognitive aspects of the interaction and the social contexts surrounding it.
The studies came from @number@ countries.
The studies demonstrated low to moderate positive effects for interventions used by occupational therapy practitioners to improve older driver performance.
The studies differed in their included populations , duration of follow-up , and interventions ( e.g. , exercise ) .
The studies estimating incidence done in Stockholm and Rotterdam reported non-significant reductions.
The studies focused on physical activity , weight loss , nutrition , and diabetes.
The studies included mainly two parts.
The studies on ICDs in elderly patients are limited and some of them are case reports about pathological gambling and kleptomania.
The studies published in English have been assessed , and the best and most recent evidence was included in the current study.
The studies reported data on @number@ participants with @number@ years of follow-up and in @number@ participants with three years of follow-up.
The studies reviewed included two RCTs , six prospective controlled trials ( PCTs ) and one cohort study.
The studies should have provided information about benefits after CBTs to older adults with depression and cognitive deficits.
The studies surveyed in this review reveal that aging is associated with cortical hyper-activity ( but also subcortical hypo-activity ) during performance of bimanual tasks.
The studies that appropriately adjust for confounding by other fats support the dietary fat composition hypothesis.
The studies were carried out on samples from @number@ individuals who died without any signs of neurologic dysfunctions.
The studies were classified into cross-sectional and longitudinal subsets.
The studies were classified into cross-sectional and longitudinal subsets.
The studies were divided into Part I ( neuroimaging ) and Part II ( chemical biomarkers ) .
The studies were heterogeneous both in terms of intervention components , setting , and outcomes used.
The studies were heterogeneous with regard to the population investigated and the statistical procedures used to compare the methods and equations with the gold standard.
The studies were performed with the help of SF-36 inquirer and indicated that health status aggravation of the liquidators also affected their life satisfaction.
The studies with the largest samples are those with raltegravir and lamivudine.
The study adopted a qualitative approach in which the signs , meanings , and actions model was used in the data collection and analysis.
The study aimed at describing the pattern of ED use by older patients and main presenting complaints.
The study aimed at determining the characteristics of non-verbal communication of the older people living in old people's homes ( OPH ) .
The study aimed at to identify the difficulties lived by the families of elderly with chronic conditions looking for assistance in the Basic Health Units.
The study aimed to assess a possibility of premature cardiac aging in SA and AC subjects.
The study aimed to assess efficacy of a standardized T. foenum-graecum de-husked seed extract in reducing menopausal symptoms in healthy aging women.
The study aimed to describe the prevalence of sarcopenia and discussed the applicability of different diagnostic criteria in Chinese older adults.
The study aimed to evaluate the safety and efficacy of vibration anesthesia for these facial injections.
The study aimed to explore associations between sexual function , demographic variables , health and menopausal status among middle-aged Iranian women.
The study aimed to quantify these contributions to SV in patients with PR.
The study aims to assess the feasibility and utility of a unique surgical palliative care immersion training program.
The study aims to determine the spatial and temporal variation of a longevous region and explore the correlation between longevity and socioeconomic development.
The study aim was to determine the contribution of dementia related pathologies to the association of conscientiousness with late-life cognitive health.
The study aim was to evaluate the impact of age and target-organ damage on the prognostic value of ambulatory BP.
The study aim was to evaluate the implementation of group- and home-based exercise falls prevention programs delivered through community health agencies to community-dwelling older people.
The study aim was to explore the perceptions and preferences of older adults and their family members about a fall risk assessment system.
The study aim was to test the hypothesis that motor function undergoes accelerated decline proximate to death.
The study also adds to the available literature on the effectiveness of pharmacists ' collaborative contribution to the care of these high-risk patients.
The study also aimed to explore the sociodemographic and anthropometric correlates of HGS.
The study also aimed to undertake initial psychometric analysis on two new outcome scales designed to measure knowledge and confidence in dementia care.
The study also ascertains several demographic , medical , social , environmental , clinical , nutritional , and neuropsychological determinants and lifestyle activities.
The study also assessed the extent of potentially inappropriate medication use ( using potentially unnecessary medications or potentially inappropriate prescribing ) among misdiagnosed patients.
The study also emphasizes the importance of lamins in nuclear assembly and chromatin organization.
The study also evaluated changes in participant's employment status , wheelchair use , and subjective changes in function using the Lamb and Chan questionnaire.
The study also explored the significant interactions among these factors.
The study also provides insight into the strategies physicians use to link older persons to CSSs and their recommendations for change.
The study also underscores the importance of including comparable complex objects when investigating face processing across the lifespan.
The study assessed disability using the activities of daily living ( ADL ) .
The study assessed self-care behaviors including medication adherence , exercise , healthy diet , and self-monitoring of blood glucose.
The study assessed whether significant changes occurred in clinical , patient satisfaction and activation measures after the intervention compared with baseline.
The study assesses placental peptides and maternal factors as potential predictors of gestational diabetes among pregnant women.
The study can be further developed with a suitable database for male and female Masters performances to facilitate longitudinal studies , which are currently lacking.
The study cohort comprised LTC facility residents aged > or = 60 years who had a diagnosis of COPD.
The study cohort comprised @number@ brain donated to CFAS.
The study cohort consisted of @number@ children aged from @number@ to @number@ years and @number@ aged from @number@ to @number@ years.
The study cohort consisted of @number@ patients implanted from @date@ through @date@ at our clinic.
The study collected data from a total of @number@ subjects aged ≥ @number@ years at baseline.
The study compared prevalence and predictors of frailty in HIV-infected and uninfected postmenopausal women.
The study comprised African ( N = 277 ) and Caucasian ( N = 326 ) men and women.
The study comprised @number@ consecutive @number@ ± @number@ years old ( mean ± SD ) subjects ( @number@ women and @number@ men ) .
The study comprised @number@ Japanese patients with LOH symptoms ( > 27 points on the Aging Males Symptoms Scale ) .
The study comprised @number@ students of the U3A in Poland , located in the city of Bydgoszcz.
The study comprised @number@ subjects : @number@ aMCI patients , @number@ AD patients and @number@ normal controls ( NC group ) .
The study comprised @number@ women aged @number@ years.
The study concerning the elderly with autism showed that the difference in quality of life is similar in the elderly.
The study concludes that addressing the barriers to engaging in community activities may help minimize burden of depression among the elderly population in South Africa.
The study confirmed a logarithmic character of the learning slope and is consistent with other studies.
The study confirms that the CDT is sensitive enough to screen for cognitive impairments in schizophrenia.
The study considers candidate proteins seen in cohorts other than AIBL and candidates previously discovered in the AIBL cohort.
The study consisted of a convenience sample of four focus groups ( n = @number@ ) from a NH in central Florida.
The study consisted of an open-label titration phase followed by a 12-week double-blind maintenance phase.
The study data comprised @number@ observations from @number@ older adults over a 12-year period.
The study data were analysed using hierarchical regression analysis , and the three sets of regression models were run for each sex.
The study dates were @date@ to @date@ .
The study dates were @number@ to @number@
The study demonstrated that the @number@ nm thulium laser could achieve injury patterns capable of skin rejuvenation.
The study demonstrates that CGA provides insights into understanding the needs of elderly Chinese patients with cancer.
The study demonstrates the feasibility of interactive group in a virtual environment for engaging members in meaningful interaction.
The study demonstrates the long-term consequences of flight and expulsion during childhood in aging former refugee children more than @number@ years later.
The study did not find a predictive role for AMH in predicting spontaneous onset of pregnancy.
The study discussed the importance of senior centers as a community-based resource in providing social integration through a variety of activities among non-white older women.
The study drug was coded in a manner that maintained the blinding.
The study emphasized the role of the cognitive-executive aspect of task performance in healthy older adults.
The study emphasizes the need for more in-depth research focusing on specificities and backing the evaluation and implementation of public policies for the indigenous population.
The study employed a multistage cluster sampling strategy to identify participants by stratifying the population by age and setting.
The study employed a pretest-posttest single group design.
The study endpoints were time to reepithelialization , erythema , and pigmentation changes.
The study end point was mortality or survival upon discharge.
The study enrolled both opioid-experienced and opioid-naïve patients.
The study establishes the influence of age and activity on performance of floor-sitting.
The study estimated the occurrence in poststroke dementia as a function of prestroke cognitive status and incident stroke.
The study examined effect of caregiving and ageing simultaneously in four groups of participants.
The study examined employers ' knowledge of and attitudes toward working carers who care for aging family members.
The study examined impact on social inclusion , carer burden , and quality of life and daily living activities for a person with dementia.
The study examined @number@ women over the age of @number@
The study examined racial / ethnic differences in the association between symptoms of depression and self-rated mental health among older adults.
The study examined well-being and depression of elders.
The study examined whether mental stimulation received in the workplace positively affects cognitive functioning and rate of cognitive change.
The study examines how older men and women would prefer to be addressed for health and prevention programs.
The study examines the effects of ethnic clusters and independent living arrangements on adaptation of elderly immigrants from the Former Soviet Union.
The study explored age-related differences in the effects of context change on recognition memory by presenting object names ( Expt.
The study extended previous training studies by suggesting resting-state ALFF as a marker of intervention-induced plasticity in older adults.
The study filler was well tolerated , with only one related AE ( injection site bruising ) reported.
The study fi ndings suggest that urban , more-educated , elderly males are more active in all aspects of life and have longer DFLE.
The study focused on the participants ' knowledge about health and disease prevention and how they preferred to be approached and addressed.
The study focus was on middle and old age given the change and increasing diversity in health and health care policy , such as Medicare.
The study followed a case-control cross-sectional design.
The study found significant correlation among levels of education , stress levels , happiness levels , and perception of benefits of herbal medicine consumption.
The study found that for QOL , two variables had only direct effects : years in ADHC and acculturation.
The study further highlights the importance of domain-specific testing to parse out the complex cognitive phenotypes of VGKCC -Ab AE.
The study group affiliation was a key variable conditioning the relations between the analyzed features.
The study group consisted of @number@ maternally unrelated Latvians ranging in age from @number@ to over @number@ years.
The study group consisted of @number@ women and @number@ men , at the average age of @number@ ± @number@ years.
The study group consisted of @number@ women between the ages of 60-90 years ( Older Women ) .
The study group consisted of thirty-two patients with compensated Child A-C , HCV-related cirrhosis.
The study group included @number@ patients ( @number@ females , @number@ males ) aging from @number@ to @number@ years with different stages of ARMD.
The study groups consist of randomised schools receiving the Smokerface poster campaign and control schools with comparable baseline data ( no intervention ) .
The study groups had significant differences in mean BMI.
The study group underwent yoga training for @number@ hours per day on @number@ consecutive days.
The study group was divided into a derivation ( @percent@ ) and a validation ( @percent@ ) cohort.
The study had a low attrition rate.
The study has been registered on the website www.clinicaltrials.org ( TRIAL REGISTRATION NUMBER : NCT01700556 ) .
The study has demonstrated that miR-34a is a common link in both HIV and antiretroviral therapy-mediated vascular aging.
The study helps to understand controversial findings in literature about morphological properties of TLHIs in DISH-affected spines.
The study highlights that strategies to reduce weight in obese and overweight elderly women could have a positive influence on disease burden in late-life.
The study highlights the importance of greater attention to the cumulative effect of problems with aging in women , especially those related to gender specificities.
The study highlights the potential benefits of multi-time scale longitudinal designs for the study of individual function and development.
The study highlights the relevance of early interventions in the context of COPD to prevent carers ' burden.
The study illuminated the NP experience in caring for the older adult while addressing the complexities of medication management through narrative stories in practice.
The study illustrates a parsimonious way of defining CR and provides empirical support for the CR hypothesis.
The study implies age-related impairments in a general neuronal inhibition mechanism and a specific response inhibition mechanism.
The study included a 5-week aging phase , an @number@ month exposure phase , and a @number@ month post-treatment ( exposure ) phase.
The study included forced spirometry ( FVC , FEV1 , PEF ) and functional tests ( gait speed , up & go ) .
The study included healthy individuals of 20-90 years of age.
The study included measurement of Deoxypyridinoline ( DPD ) .
The study included @number@ caregivers of AD patients.
The study included @number@ children of @date@ years old.
The study included @number@ community-dwelling persons with a mean age of @number@ years.
The study included @number@ Danish middle-aged or older twins who provided data on the number of teeth at baseline by structured interviews.
The study included @number@ elderly individuals aged @number@ years and older , who have a chronic disease.
The study included @number@ elderly subjects recruited from the University of California , San Francisco Memory and Aging Center.
The study included @number@ participants , @number@ million person years and @number@ dementia related deaths.
The study included @number@ patients aged @number@ ± @number@ years ( range : @number@ to @number@ years ) .
The study included @number@ patients in whom potentially harmful medication errors were detected , and @number@ sex- and age-matched controls.
The study included @number@ Polish patients ( mean age @number@.2±6.5 years ) , among them @number@ men and @number@ women.
The study included @number@ premenopausal women at baseline ( age : @number@.9±1.9 years ; BMI : @number@.3±2.3 kg / m2 ) .
The study included @number@ Swedish women aged @number@ years from the population-based OPRA cohort who attended follow-up at @number@ and @number@ years.
The study included @number@ women aged from @number@ to @number@ years.
The study included panoramic radiographs of @number@ persons ( mean age @number@ years , SD ± @number@ years ) .
The study included @percent@ females ; the mean age of the participants was @number@ years.
The study included @percent@ females ; the mean age of the participants was @number@ years , and their average education was @number@ years.
The study included those aged 25-69 at baseline ( n = @number@ ) .
The study included three phases.
The study includes the vision , methodology , and specific steps taken to implement this spiritual care program and methods to measure its efficacy.
The study includes two groups of @number@ hospitalized elderly participants : the experimental group and the control group.
The study incorporated a quasi-experimental design with random selection of participants , stratifying for age and gender.
The study investigated differences in the Five-Factor Model ( FFM ) domains and facets across adulthood.
The study investigated the biological correlation between the top loci through protein-protein interaction and changes in the gene expression and methylation levels.
The study involved case note review and a patient satisfaction survey.
The study involved @number@ participants.
The study is approved by the Regional Ethical Committee ( Capital Region , Copenhagen , Denmark , number H-3-2014-017 ) .
The study is a qualitative one , conducted on the basis of in-depth , semi-structured interviews with the mothers.
The study is a secondary analysis of data collected in a larger study ; @number@ older Norwegians and @number@ older Canadians were included.
The study is devoted to the problem of congenital disorder cleft palate in elderly population.
The study is limited by different mammography systems and its cross-sectional rather than longitudinal nature.
The study is the first to examine the nonamnestic subtype.
The study lasted six months and all participants were subject to monthly controls / checks.
The study may explain the increased incidence of diastolic heart failure in elderly women with hypertension.
The study measured listener sensitivity to increments in the inter-onset intervals ( IOIs ) of successive 20-ms 4000-Hz tone bursts in isochronous sequences.
The study methodology and number of study subjects are sufficiently robust to provide a high Evidence Level for much of the data.
The study objective was to evaluate the relationship between retinal and brain lutein and zeaxanthin in humans.
The study of aging , and the diseases that accompany it , has accelerated significantly in the last decade.
The study of autophagy has exploded over the last decade or so , branching into numerous aspects of cellular and organismal physiology.
The study of ECM macromolecules production using ELISA showed an increase of hyaluronic acid and versican production but no changes were observed for decorin.
The study of health behaviors and fostering health-behavior change is an important endeavor even in old age.
The study of miRNAs is rapidly growing and recent studies have revealed a significant role of miRNAs in vascular biology and disease.
The study of patients with MCI has led to spectacular advances in understanding the prodrome of the disease.
The study of postnatal skeletal repair is of immense clinical interest.
The study of preclinical cases is valuable to gain insights into early pathological features of corticobasal degeneration and its progression.
The study of stem cells in the epidermis is a rapidly emerging field.
The study of structural asymmetries provides important clues to the neuroanatomical basis of lateralized brain functions.
The study of T cell biology has been accelerated by substantial progress at the technological level , particularly through the continuing advancement of flow cytometry.
The study of the effect of aging on the functional neuroimaging of posture and gait has only recently been undertaken.
The study participants are followed up every @number@ to @number@ years for quality of life , morbidity , and mortality.
The study participants were interviewed every 3-6 months from @date@ and @date@ .
The study particularly demonstrated a mixed representation regarding the significant trajectories of intact and reduced physical performance over time.
The study patients were categorized into five subgroups by age intervals of @number@ years.
The study period is @number@ weeks , and the patients are assessed at baseline , @number@ and @number@ weeks.
The study period was 1996-2007.
The study period was between April and @date@ .
The study period was divided into 1-year intervals.
The study period was @number@ to @number@
The study population comprised Danes born in @number@ and a replicate sample of the @number@ cohort.
The study population comprised family caregivers of persons aged @number@ years and older receiving social services and diagnosed with dementia disorders.
The study population comprised female participants of the baseline visit of the population-based LifeLines Cohort Study.
The study population comprised @number@ middle-aged French women.
The study population comprised @number@ ( @percent@ ) of all eligible @number@ elderly residents.
The study population comprised patients with trauma who were hospitalized from April to @date@ .
The study population consisted of @number@ community-dwelling elderly participants aged @number@ or older.
The study population consisted of @number@ community-dwelling individuals ( 75-98 years , @percent@ female ) .
The study population consisted of @number@ community-dwelling PWDs aged @number@ and older , @number@ formal caregivers , and @number@ informal caregivers residing in Israel.
The study population consisted of @number@ elderly subjects : @number@ were hospitalized following hip fracture and @number@ control subjects were outpatients.
The study population consisted of @number@ participants without atrial fibrillation at baseline for whom baseline levels of serum potassium were measured.
The study population consists of adults ≥21 years of age with fibromyalgia who meet American College of Rheumatology @number@ and @number@ diagnostic criteria.
The study population included all @number@ inmates incarcerated in the Texas prison system for any duration during @number@
The study population included elderly adults aged @number@ years or older interviewed during either of the two survey waves.
The study population was @number@ long-lived and @number@ middle-aged Danes.
The study population was predominantly male ( @percent@ ) , aging ( @percent@ ) over @number@ years and educated ( @percent@ ) .
The study population was the co-resident primary caregivers of home care nursing service users.
The study presents a 3D method for subdividing a trabecular network into horizontal and vertical oriented bone.
The study presents the results of many-years research conducted using biological objects of different organization level.
The study product was well tolerated.
The study protocol is registered at PROSPERO ( CRD @number@ ) .
The study protocol was published on PROSPERO ( CRD42015024916 ) .
The study provides an instructional foundation for the control and prevention of CVD in Beijing , China.
The study provides further insight into the physiology of acute SD in different sex and menstrual phases.
The study provides healthcare professionals insight into improvement of quality of care in all three countries.
The study provides quantitative basis for the future distribution of medical resources.
The study provides the first behavioral evidence regarding a mechanism of how increases in leg strength improve healthy old adults ' gait speed.
The study purpose was to describe health care professionals ' experiences of caring for older people with dementia living alone.
The study quality of the three RCTs was high ; however , measurement outcomes , interventions , and follow-up time periods differed across studies.
The study repeated for the individual CV conditions showed that reduced eGFR was associated with mortality only in chronic ischemic heart disease.
The study reported here sought to elucidate the benefits and drawbacks of different laser systems in the treatment of patients with BPH.
The study reported sex differences in QUS growth curves and an inverse relationship between BMI and speed of sound ( SOS ) measures.
The study results can help inform urban design to encourage walking.
The study results can help to develop effective physical activity programs for older adults in the community.
The study revealed that the number of CD271 ( + ) cells in the epidermis and dermis decreased with aging.
The study revealed the significant difference between the number of the renal glomeruli in the subjects under and above @number@ year old.
The study reveals that with age , telomere erodes in length.
The study sample comprised @number@ randomly invited subjects aged @number@ to @number@ years , and had a participation rate of @percent@ at follow-up.
The study sample comprised @number@ residents with complete data at baseline on delirium , dementia , and depression.
The study sample consisted of @number@ AD patients and @number@ cognitively normal control subjects.
The study sample consisted of @number@ adults from the Framingham Offspring cohort.
The study sample included adult children aged @number@ or older with living parents or parents-in-law.
The study sample included @number@ clients receiving community based home care and their family caregivers in Korea.
The study sample included @number@ males ( mean age @number@.98± @time@ ) and @number@ females ( mean age @number@.65±16.62 years ) .
The study sample included @number@ patients treated with NPWT + CCO and @number@ patients who received only NPWT.
The study sample reported slightly positive attitudes ( @number@ ± @number@ ) .
The study sample totaled @number@ male workers ( @number@ in construction trades ) in the baseline.
The study sample was comprised of subjects from the HRS ( N = @number@ ) and the KLoSA ( N = @number@ ) .
The study sample was comprised of subjects from the HRS ( N = @number@ ) and the KLoSA ( N = @number@ ) .
The study sample was not restricted to a specific age group.
The study sample was @number@ older residents in a community ; all were at least @number@ years old.
The study sample was representative of the general population.
The study sample was restricted to non-obese Filipino Americans ( n = @number@ ) and non-Hispanic whites ( n = @number@ @number@ ) .
The study's authors conclude that elder self-neglect is prevalent , especially in elderly adults with poorer QOL.
The study showed no relationship between TT and FT and the concentrations of metals.
The study showed small but significant differences in scapular kinematics and scapulohumeral rhythm between children and adults.
The study showed that Aryan-origin ethnic skin was more wrinkled and darker than that of Mongolian.
The study showed two interrelated themes reflections on life and ubuntu - an orientation towards others.
The study shows that active older adults can benefit from an intergenerational service-learning experience.
The study shows that EAAs ingestion by old subject is associated with reduced muscle EAA uptake.
The study shows that homebound status is a prevalent problem in old-old Israelis.
The study shows that mast cell quantity in derma increases with age.
The study subjects were @number@ Finnish girls who were 10-13 yr old at baseline.
The study suggests nucleic acid oxidation is a general event in neurodegeneration.
The study suggests that effective interventions aiming to reduce work-related stress should focus on both primary and secondary prevention.
The study suggests the importance of the family context for healthy aging in adults with Down syndrome.
The study suggest that the elderly felt more comfortable and gained more pleasure psychologically while participating in exercises less intensive.
The study team performed a thorough search of the literature using six online databases.
The study tested whether age , sex , or task complexity moderate the effect of attentional focus on motor learning.
The study underscores the importance of SWB for health and longevity , particularly for older adults.
The study unveils novel defense mechanisms exist for C. elegans in facilitating enhanced immunity by RACK-1 against SF infection.
The study used a 3 : 1 propensity-matched cohort design.
The study used a daily process design to examine the role of psychological resilience and positive emotions in the day-to-day experience of pain catastrophizing.
The study used a nested case-control design involving @number@ subjects aged @number@ years and older and @number@ controls.
The study used an input-process-outcome framework , a descriptive correlational design , and a mailed survey with a random sample of staff nurses.
The study used sociodemographic data from a descriptive survey form.
The study utilized the 3-stage design standard approved for PI-CME.
The study was addressed to assess the biological effects of this serpin in vivo using a SB3 transgenic mouse model.
The study was aimed at analyzing time and clinical characteristics of the diabetics with an onset of the disease after @number@ y.
The study was aimed at exploring the impact of early discontinuation of antidepressant treatment on the risk of antidepressant re-initiation.
The study was approved by Research Ethics Committee.
The study was approved by the institutional review board ( the institutional ethics committee ) .
The study was based on predominantly retrospective and , for a period of @number@ years , prospective data.
The study was based on the ecological model.
The study was carried out between @number@ and @number@ however , results have never been fully reported.
The study was carried out on fifteen healthy young , middle-aged subjects ( range 36-55 years , mean age±s.e.
The study was carried out on @number@ primiparous women from February to @date@ .
The study was carried out with @number@ children ( 18-40 months ) in @number@ child-care-centre groups.
The study was conducted according to generally accepted principles.
The study was conducted after coordinating with schools and obtaining written consent from students ' parents.
The study was conducted at a tertiary care center in the United States.
The study was conducted at Columbia University Medical Center between @number@ and @number@
The study was conducted at Istanbul Research and Training Hospital Neurosurgery Clinic.
The study was conducted at the University of Modena and Reggio Emilia , Italy.
The study was conducted between @date@ and @date@ .
The study was conducted from @date@ , through @date@ .
The study was conducted from @date@ , to @date@ .
The study was conducted from @date@ , to @date@ .
The study was conducted from @date@ , to @date@ .
The study was conducted from @date@ , to @date@ ; analysis was performed from @date@ , to @date@ .
The study was conducted from @date@ to @date@ ; data analysis was performed from @date@ to @date@ .
The study was conducted in a vestibular and balance laboratory at a tertiary medical center.
The study was conducted in Baltimore , Maryland , from @number@ to @number@
The study was conducted in multiple phases , with qualitative and quantitative methodologies.
The study was conducted in @number@ general practices in Croatia between @date@ and @date@ .
The study was conducted in the district of Aveiro ( Portugal ) .
The study was conducted in two in-patient hospice units located near Lisbon , the capital of Portugal.
The study was conducted in Xi'an , China.
The study was conducted on @number@ patients who were diagnosed as having lumbar disc herniation and underwent cervical spine MRI.
The study was conducted over a six-month period in two consecutive blocks.
The study was conducted prospectively on @number@ consecutive patients ( normal IIEF-5 before surgery , ≥ @number@ ) who underwent TURP.
The study was conducted using standard meta-analysis methodology.
The study was conducted within the community infrastructure of Cooperative Extension Centers.
The study was designed in a cross-sectional and observational manner.
The study was designed to determine whether these declines are related to the extent of cortical or subcortical shrinkage.
The study was developed at the Dysautonomia Center , New York University Medical Center.
The study was included in the Australian and New Zealand Clinical Trial Register residential care facilities.
The study was IRB approved and HIPAA compliant with informed consent waived.
The study was limited by the cross-sectional design.
The study was performed between @date@ and @date@ .
The study was performed on a population of @number@ volunteers ( @number@ women and @number@ men ) for over @number@ years.
The study was performed on pineal samples of @number@ fetuses and children whose brains were autopsied and diagnosed during 1998-2002.
The study was restricted exclusively to cases of moderate and severe lower eyelid retraction addressed by means of midface lifting.
The study was run in a sample of older adults aged 55-87 , taking advantage of the high amount of hippocampal variability present in aging.
The study was undertaken to identify functional SORL1 mutations in patients with LOAD.
The study will also compare the health effects of electronic vs traditional vs mixed cigarette smoking.
The study will also examine post-training benefit retention , an important issue for older adults , usually omitted from exercise studies.
The study will enroll @number@ people aged @number@ years and over.
The study yielded @number@ main findings.
The suACC clusters of increased ReHo and FC spatially overlapped.
The subcellular localization of Rheb and its interacting proteins critically regulate its activity and function.
The subcellular translocation of CDK5 was monitored during gastric cancer cell proliferation.
The subciliary approach is the most commonly used and technically less challenging for surgeons experienced in facelift techniques.
The subclinical group showed overall lower cortisol levels compared with the healthy group.
The subclinical phenotypes of asymptomatic members of these families have not been evaluated with respect to TERT mutation status or telomere length.
The subcutaneous fat compartments of the face may be differentially affected by facial aging.
The subepithelial accumulation of drusen was first noted in the specimen from the late 60s.
The subfactors Neediness and Connectedness were differently related to personality traits.
The subfoveal choroidal thickness , large choroidal vessel layer thickness , medium choroidal vessel layer-choriocapillaris layer thickness , and large choroidal vessel diameter were estimated.
The subgenual anterior cingulate cortex ( sgACC ) presents altered functional connections with other regions of the brain in individuals with depression.
The subgroups of younger men and men with better preoperative function were more likely to maintain their EF and SF through @number@ yr following RP.
The subgroups were classified according to @number@ comorbid conditions prevalent in the older population.
The subgroup with normal cognition ( n = @number@ ) showed no benefit with donepezil and no increase in recurrence of major depression.
The subjective alertness factor was significantly impaired with Zp.
The subjective nasal complaints and quality of life status were recorded by means of the NOSE and SNOT-20 questionnaires.
The subjective weathering model contends that subjective aging is a key component of the stress process.
The subject of this study was the influence of schizophrenia on the amount of OH ( • ) in human serum blood.
The subjects aged of @number@ years or more are the most represented among the BZD users in France.
The subjects attempted to meet the ATS / ERS @number@ guidelines when performing forced expiratory spirograms.
The subjects became motivated to participate in training and continued the exercises.
The subjects comprised @number@ young women and @number@ elderly women residing in a nursing home.
The subjects comprised @number@ young women ( young group ) and @number@ elderly women who resided in nursing homes or chronic care institutions.
The subjects continuously wore a lifecorder during a 7-day period and the nutritional intake was measured before the initial blood sample collection.
The subjects had intact ocular lenses in both eyes throughout the study.
The subjects included in the statistical analysis were @number@ men and @number@ women.
The subjects in group H were taking rosuvastatin ( 20mg / d ) for @number@ months before the second scan.
The subjects in study @number@ were @number@ children aged @date@ @number@ years with a history of Kawasaki disease.
The subjects in study @number@ were @number@ healthy children aged @date@ @number@ years.
The subjects in the IG will be lent a smartphone and a smartband for a 3-month period , corresponding to the length of the intervention.
The subjects of the study were @number@ patients with extrahospital bacterial pneumonia ( @number@ men and @number@ women ) .
The subjects ' perception of friend support had different effects on the depressive symptoms of elderly adults with different marital statuses.
The subjects performed a fatiguing trunk extension-flexion exercise on a Roman chair until exhaustion.
The subjects performed lateral stepping over an obstacle with and without vertical and horizontal bars.
The subjects performed the recall test three times ( each time with a different list ) at least @number@ week apart.
The subjects received a single treatment using settings that delivered the highest RF energies suggested from the new recommended protocols.
The subjects refrained from further heavy physical exercise and consumed a standardized diet for the entire experimental period.
The subjects ' self-assessment improved by @number@ ± @number@ points.
The subjects that underwent CCT did not show an increase of BDNF after bed rest , and showed an anti-insular modification pattern in metabolism.
The subjects then had their DLPFC GABA content measured by single-voxel proton magnetic spectroscopy.
The subjects underwent dental radiography , periodontal examinations and brain MRI.
The subjects usually receive disability benefits and retirement.
The subjects were all right-handed and include both men ( n = @number@ ) and women ( n = @number@ ) .
The subjects were asked to elevate and lower their arm in the scapular plane.
The subjects were assessed at baseline and after 24weeks.
The subjects were chosen to give an even age and gender distribution.
The subjects were classified into five groups according to age , smoking status and presence of COPD.
The subjects were divided into three age groups : group @date@ -30years ; group @date@ -50years ; group @date@ -70years.
The subjects were divided into two groups-the soft drusen and control groups-based on the presence of soft drusen in the fundus photographs.
The subjects were evaluated by skin complexion analysis and 3-dimensional imaging system at @number@ @number@ and @number@ days.
The subjects were examined while sitting in an upright position , with the back against a wall to control movement.
The subjects were followed-up on the phone.
The subjects were mainly dependent on alcohol and sedative drugs from the group of benzodiazepines.
The subjects were newly certified as eligible for long-term care insurance between January and @date@ in Korea.
The subjects were non-responsive to classic dermatological treatment or had clinical manifestation of hyperandrogenism.
The subjects were not using any drug that could affect IGF-1 levels.
The subjects were @number@ adults ( @number@ men and @number@ women ) aged @number@ ± @number@ years from a rural village.
The subjects were @number@ boys and girls ( @number@ boys , @number@ girls ) aged @number@ to @number@ years who participated in regular sports activities.
The subjects were @number@ consecutive autopsy cases ( @number@ men and @number@ women ) of community deaths.
The subjects were @number@ elderly people over @number@ years of age.
The subjects were @number@ Japanese males who underwent a basic health checkup.
The subjects were @number@ ± @number@ yrs ( mean ± SD ) of age and @percent@ female.
The subjects were @number@ young healthy children aged 2-7 years old separated in @number@ groups for children of different age.
The subjects were recruited from the general population.
The subjects were then given @number@ mL of mineral water.
The subjects were three female patients with auditory neuropathy.
The subjects with central obesity , elevated blood pressure , or impaired fasting glucose also had lower serum RNase-L levels in comparison to those without.
The subjects with Parkinsonism and arthritis demonstrated higher levels in these minerals than healthy subjects.
The subject therefore prioritizes one of the tasks.
The submissions mentioning homebirth most commonly discussed the ' Benefits ' and ' Barriers ' in accessing this option of care.
The subordinate verbs varied in whether or not they occurred in ditransitive constructions ( served vs. kissed ) .
The subscales demonstrated good internal consistency ( Rasch reliability @number@ to @number@ ) and test-retest reliability ( Spearman coefficients @number@ to @number@ ) .
The subsequent rise in well-being was , however , also diminished in this group.
The subsequent study of twins showed that the transcriptional activity of a third of the differentially regulated genes is heritable.
The subsequent transcription of HIFα-dependent target genes results in cellular metabolic reprogramming and increased cellular glucose consumption.
The subset of proteins included FABP , CgA , MMP-2 , and PPP as strong predictors in the model.
The subsisting peptidome encompassed @number@ distinct heart-associated peptides , of which @number@ ( @percent@ ) had not been identified in a recent Drosophila peptide compendium.
The substance is also an active ingredient of some over-the-counter diet supplements.
The substance used , the level of hyaluronic acid reticulation , and the depth of the injection depend on the injection site and intended effect.
The substrates are taken into the lysosomes through LAMP-2A and are rapidly degraded by the lysosomal enzymes.
The subtests that best classified the subjects were of the lexical-semantic type but also related to metalinguistic capacity and language organisation skills.
The subthalamic nucleus ( STN ) plays a crucial role in the surgical treatment of Parkinson's disease ( PD ) .
The subtypes were subsequently characterized on clinical and demographic variables.
The Successful Aging after Elective Surgery study ( SAGES ) enrolled @number@ adults age ≥70 years without dementia scheduled for major surgery.
The successful strategy based on the activation of cell death in Ras-expressing cells is associated with the suppression of kinases involved in Ras pathway.
The successful treatment of comorbid conditions that increase central nervous system inflammatory responses has general health benefits and should be part of clinical practice.
The successive application of @percent@ retinyl retinoate cream for @number@ months showed decreased depth and area of wrinkles in comparison with @percent@ retinol cream.
The success of antiretroviral therapy has led some people to now ask whether the end of AIDS is possible.
The success of endoscopic retreatment largely depends on the severity of rebleeding and ulcer characteristics.
The success of experimental biology was possible due to the use of model organisms.
The success of forensic genetics has led to considerable numbers of DNA samples that must be stored.
The success of prosthetic surgery has led to an increase in the percentage of the population having more than one prosthetic implant.
The success of the overall initiative will be measured primarily according to reduction in avoidable hospitalizations of long-stay nursing facility residents.
The success of these techniques depends on integrating biomaterial , biologic , and biomechanical aspects with clinical considerations.
The success of this approach hinges on the accuracy of rare variant imputation , which remains controversial.
The success of this program of research suggests that strategies to optimize non-feminizing estrogens for use in postmenopausal women can be successful.
The success of VGSC treatment in AD was unexpectedly variable , ranging from very beneficial to plain detrimental.
The success rate in avoiding highly invasive treatment was of @percent@ , since only @number@ patients needed definitive tracheotomy ( @percent@ ) .
The success rates of 1 ( st ) -line antibiotic therapy , mortality , length of hospital stay , and total antibiotic costs were compared.
The success rates of adequate and inadequate root canal treatment were not significantly different ( p > 0.05 ) .
The suffering sometimes was caused by various caring actions , that is , unnecessary suffering.
The suggested age at which acceleration of hippocampal atrophy starts is @number@ years.
The suggested approach could be used to support the choice of the initial dose in clinical trials for children ≤3 months old.
The suggested system is expected to have more practical clinical applications.
The suicide attempters differed in several aspects of social problem-solving on a self-report scale.
The Suicide Intent Scale planning subscale was used to describe the degree of planning associated with the most lethal attempt.
The suitability of elastic cartilage from the epiglottis as an elastin source for age estimation based on AAR was tested.
The suitability of the mouse model for the study of osteocalcin as a therapeutic target also appears ambiguous.
The Sullivan Method was applied to estimate CILE and CIFLE.
The Sullivan method was used to compute DFLE.
The summary incidence commonly presented for the ≥65 age group considerably underestimates LRTI / CAP rates , particularly among older individuals within this group.
The summary relative risk ratio ( RR ) or odds ratio ( OR ) and @percent@ confidence interval ( CI ) were calculated.
The sun-exposed areas had a more than @percent@ higher AGE-CML score than the protected areas.
The Sunlight Omnisense 7000P was used to assess bone quality of the distal @date@ radius and midshaft tibia.
The super-aging society in Japan is currently experiencing growing demand for treatments that improve health and longevity.
The superficial musculoaponeurotic system ( SMAS ) was addressed in @number@ patients ( @number@ percent ) with a SMASectomy.
The superimposition of aging-related lesions on other kidney diseases evolving in the elderly population makes the clinical picture more complex and reaching diagnosis more challenging.
The superior and inferior locations of the liver were also recorded with respect to the spine.
The superior division age effect was especially notable in axial and radial diffusivity.
The superior effect of AG2 on orthostatic tolerance could not be related to concomitant changes in PV or aerobic power.
The superiority of power functions of the opiate duration of exposure underscores the significance of the duration of treatment and of putative senescence induction.
The superiority of \ "sequential \ " therapy over standard triple therapy has not been definitively established.
The superior protection for the aged observed with VRP ( @number@ ) -based vaccines was confirmed in a lethal influenza virus challenge model.
The superior surface morphology had the least congruence ( @number@ ) , while the ventral symphyseal margin had the most ( @number@ ) among scores.
The superior validity of OLQ-11 over OLQ-13 was supported by the better model fit in the confirmatory factor analysis.
The superoxide dismutase activity of GEB at @number@ and @number@ mg / mL was @percent@ and @percent@ , respectively.
The supplementary motor area ( SMA ) has been regarded as a third speech area.
The supplement was administered daily on bagel bits that were usually eaten within minutes by the mice.
The suppleness of the dermis is affected by the formation of bridges between proteins and sugars ( Maillard's reaction ) .
The supply of urologists per capita has declined since @number@ - most dramatically since @number@
The support surface was held tilted for @number@ s and then returned to neutral over a 30-s period while the visual field continued to rotate.
The supposed perpetrator ran away from the scene in @percent@ of the cases.
The suppression of energy intake by CCK-8 infusion did not differ between the two diets.
The suppressive effect of regucalcin on brain microsomal Ca ( 2 + ) -ATPase activity was weakened in aged rats.
The suprahyoid muscles , therefore , play an important role in swallowing.
The supra-sensory vibration had a destabilizing effect , which was considerably stronger in the semi-tandem posture and affected most of the sway variables.
The sural nerve is potentially susceptible to injury , and specialized instrumentation has been developed to avoid this event.
The sural nerve showed a markedly decreased number of large and small myelinated fibres without onion-bulb formation.
The surface amine termination was confirmed by FTIR , NMR , and XPS studies.
The surface coating agent groups demonstrated more staining than the non-coated groups.
The surface layer of the aged specimen underwent the most transformation while all samples displayed decreasing transformation with depth.
The surface roughness , the area of pores and the depth of skin furrows increased with age.
The surfaces were etched with @percent@ phosphoric acid for @number@ seconds , washed and blot dried.
The surface treatment of zirconia followed the manufacturers ' instructions for each cement.
The surface was then washed and left moist ( Wet bonding ) or air-dried for @number@ seconds ( Dry bonding ) .
The surgeon completed an operative questionnaire immediately postoperatively , as well as a satisfaction questionnaire at one and three months postoperatively.
The surgeon was satisfied with the performance of the Endotine device , its ease of insertion , and the fixation provided in all cases.
The surgeon who conducts adipocyte grafting will appreciate its ease of use and remodelling volumising effect.
The Surgery and complication were recorded.
The surgery was successful , but fever and worsening dyspnea appeared and continued from postoperative day ( POD ) @number@
The surgical calculator model had an accuracy of @percent@ for predicting the reoperation rate ( Brier's score < 0.01 ) .
The surgical or endovascular repair is indicated when dissections complicate or symptoms persist despite an adequate conservative treatment.
The surgical outcomes were evaluated by the physician using the Lemperle scale and questionnaires filled out by the patients.
The surgical outcome was evaluated according to the analysis of photographs obtained before and after surgery and the analysis of pre- and postoperative measurements.
The surgical procedures were lobectomy in @number@ patients , segmentectomy in @number@ and partial resection in @number@
The surgical treatment included surgical correction of deviated bony pyramid , deviated cartilaginous pyramid , deviated lobular and deviated septa.
The surgical workload burden was assessed in @number@ and projected to @number@ based on the predicted changes in procedure rates and resource-based relative value scale.
The surprising discovery in @number@ that estrogen modulates hippocampal structural plasticity launched a whole new field of scientific inquiry.
The surrounding sclera serves to counteract excessive deformation from these forces and thus to create a stable biomechanical environment for the ocular tissues.
The survey asked about demographics and included measures to assess workplace violence , fear , stress , burnout , depression and sleep problems.
The survey assessed social networks , social support , and physical and mental health among older adults.
The survey consisted of questions associated with present physical and mental status and desire to resume ART.
The survey consisted of self-reported information on impairments , disability , participation , demographics , personal and environmental factors.
The survey covered a total of @number@ elderly subjects ( age > 65 years ) .
The survey covered rural and urban areas of @number@ states or union territories.
The survey data was first used to estimate the magnitude of household carbon emissions in different urban contexts.
The survey data were compared with the NHC data to identify the gap.
The survey highlighted the difficulty of diagnosing dementia , especially in the initial stages of the disease.
The survey included questions regarding sociodemographics , health status , access to and usage of healthcare , health behaviours and CHC use.
The survey included questions to capture the clinical and demographic characteristics of the sample.
The survey included scenarios for fall prevention interventions , including assessment / multifactorial interventions , such as those delivered through a falls clinic.
The survey instrument consisted of @number@ questions relating primarily to issues of health , finances , and the ability to practice emergency medicine.
The survey interview closest to death was used.
The Survey of Health , Ageing and Retirement in Europe Frailty Instrument ( SHARE-FI ) was used to assess the degree of frailty.
The survey population ranged from middle school students to undergraduates.
The survey responders were between @number@ and @number@ years of age and @number@ % were female.
The survey response rate was @percent@.
The survey response rate was @percent@ at baseline and @percent@ at follow-up.
The survey sample size is @number@ persons above @number@ years.
The surveys included anthropometric measurements , blood samples and structured questionnaire.
The surveys included items on demographic and health related factors , used medication and self-reported supplemental use of vitamins or minerals , and natural products.
The surveys specifically probed measurement , health outcomes , interventions , and research priorities.
The surveys were administered face-to-face at a date and time these participants went to the Association.
The surveys were conducted in six districts with a population of @number@ million.
The survey was carried out among a random sample of @number@ participants , @number@ men and @number@ women , older than @number@ years.
The survey was conducted with @number@ student nurses.
The survey was sent in Vietnamese and English , and all except one was completed in Vietnamese.
The survival and IDC models both showed excellent discrimination ( p < @number@ ) .
The survival and proliferation of rat primary astrocytes , neural precursors , and neurons upon hypoxic conditions were increased upon administration of BQ123.
The survival curve in group B was worse than that in groups A , O , and AB.
The survival curves were evenly distributed showing similar survival rates in the two groups.
The survival differences across countries and the survival disadvantage in the elderly require further investigation.
The survival durations were similar in the DCD donor and non-donor groups.
The survival estimates are based on cancer registry data of southern Italy.
The survival for nonagenarian men with CLI was @number@ months and for women @number@ regardless of the treatment modality.
The survival mechanisms that preserve the viability of terminally differentiated odontoblasts during the life of a healthy tooth have not been described.
The survival of breast cancer patients is largely influenced by tumor characteristics , such as TNM stage , tumor grade and hormone receptor status.
The survival of elderly people has improved significantly and thus centenarians are becoming the fastest growing population group.
The survival of the twins was determined through to the end of @number@
The survival probability of becoming a centenarian ( SPBC ) is defined as an estimate of the production of centenarians by a population.
The survival probability of GCIPL and IR thicknesses were significantly worse compared with circumpapillary RNFL thickness ( P ≤ @number@ ) .
The survival probability was evaluated with the Kaplan-Meier estimator , and the agreement of progression detection among the structural parameters was calculated with Kappa statistics.
The survival rate and ventricular tachycardia ( VT ) -free survival rate were calculated after the initial MI by the Kaplan-Meier method.
The survival rate calculated from SEER data was lower than the survival rate in clinical trials in the corresponding period , with differences of @number@.1%-50.7%.
The survival rate for @number@ patients with MPAP > @number@ mmHg was respectively @percent@ , @percent@ and @percent@.
The survival rate predicted by SHFM demonstrated an excellent correlation with the actual survival rate ( R ( @number@ ) = @number@ ) .
The survival time of the fruit flies which were negatively affected by exposure to H2O2 or paraquat was significantly prolonged by CSOL.
The survival was similar between the two groups , and the only independent prognostic factor for survival in the elderly patients was vessel invasion.
The susceptibility among adults ranged between low and very high and had a geographical gradient , with three countries in the low susceptibility category.
The susceptibility of erythrocytes to eryptosis increases with erythrocyte age.
The susceptibility to infection , the pathogenesis and the clinical manifestations of tuberculosis ( TB ) depend on the immunological status of the host.
The sutures are distributed evenly on the face , directly supporting the jowl , the malar fat pad , and the periorbital tissue.
The sutures are fixed medially in an artificial orifice dissected on the frontal process of the maxilla , above the alar groove.
The sutures were inserted through a @number@.5-cm incision positioned in the temporal area.
The SUVR method is expected to improve subject tolerability by allowing shorter scanning time and not requiring arterial catheterization.
The swallowing function may decrease even in healthy adults , aged over @number@ years.
The Swiss Group of Esthetic Dermatology and Skincare ( SGEDS ) pursued these questions in a two-day consensus meeting.
The symmetry of astigmatism should be considered when both eyes need cataract surgery.
The symmetry of binocular astigmatism was also studied.
The sympathetic index may be used for analysis of sympathetic nerve fiber-related problems of the internal thoracic artery.
The sympathetic nerve fiber area and sympathetic index were found to be @number@ mm² and @number@ respectively.
The symposium addressed mechanisms and biomarkers of alcohol induced damage to different organs , as well as the role of the microbiome in this dialog.
The symptomatic predementia phase of AD was referred to as MCI due to AD.
The symptom at onset was cerebellar gait ataxia , except in @number@ patient with isolated upper limb tremor.
The symptoms of vaginal candidiasis exacerbate in the second half of the menstrual cycle in premenopausal women when the serum estradiol level is elevated.
The symptoms were more severe among physically inactive men.
The synaptic deficits due to the loss of endogenous TRIAD3A could not be rescued by TRIAD3A harboring GHS-associated missense mutations.
The synaptic plasma membrane ( SPM ) cytofacial leaflet contains over @percent@ of the total SPM cholesterol as compared with the exofacial leaflet.
The synaptic proteins did not exhibit a generalized decrease in abundance ( e.g. syntaxin ) in the VaD subjects.
The synaptic toxicity of soluble amyloid-β ( Aβ ) oligomers plays a critical role in the pathophysiology of Alzheimer's disease ( AD ) .
The synaptopathology of AD is known to involve both pre- and postsynaptic components.
The syndrome appears around puberty in mice with genetic deletions of MC4R , suggesting a role of ovarian hormones.
The syndrome is characterized by progeroid appearance , decreased subcutaneous fat , hypotrichosis , macrocephaly , and in some natal teeth.
The syndrome of frailty describes older people at a higher risk for adverse health outcomes such as illnesses , hospitalisations , disability and mortality.
The syndromes were more prevalent with age except \ "all fractures \ " ( p value range < .001-.03 ) .
The synergism of HIV infection and aging has alarming clinical and socioeconomic implications.
The synergistic association-effect of these lifestyle behaviors , including diet , is unknown.
The synergistic regulations of module genes were verified by reviewing miRNA target databases and previous studies.
The synergy between these cytokines was lost when ISRE or kB elements in CXCL10 promoter were mutated.
The synergy factor was @number@ ( @number@.4-6.9 ; @number@ ) in subjects with the APOEε4 allele.
The synovial fluid circulation is driven by the bellows-like movement of the zona orbicularis and depends on hip flexion and extension.
The synovial tissue usually contained CD68-positive macrophages , but the positive cells were often restricted to certain parts of the tissue.
The synthesis of qualitative findings can offer insight into what makes interventions ' work ' and factors which may facilitate or impede their use.
The synthesized data included @number@ children from @number@ RCTs.
The system also enables the simultaneous measurement of isometric force and cytosolic Ca ( 2 + ) levels and promotes understanding vascular physiology and disease.
The systematic implementation of the SPPB in clinical practice settings may provide useful prognostic information about the risk of all-cause mortality.
The systematic review informed the project steering committee , which revised the previous recommendations.
The systematic review level of evidence is moderate , and the strength of recommendation is that VBF is likely to be beneficial.
The systematic text condensation method was applied to analyse interviews.
The system carries out collecting , storing and processing of acceleration data with further alarm generating and transferring all the measurements to remote caregiver.
The system confirms the type , quantity and timing of medication every time a recipient picks medicines up.
The system for postoperative complications was applied to assess the severity of the complications.
The system gathered all data and dispatched alerts when certain clinical conditions were met.
The system has two charge-balanced biphasic voltage-controlled stimulation channels.
The systemic and cerebral microcirculation contribute critically to regulation of local and global blood flow and perfusion pressure.
The systemic nature of RA is evidenced by the increased risk of atherosclerosis and lymphoproliferative disorders.
The system is tested on a sample set of @number@ fundus images from a clinical study , with half having drusen.
The system is very complicate and our knowledge is incomplete.
The system platform ( 1MHZ ) incorporated six independent phase controlled RF generators coupled to RF microneedles that induced skin remodeling via controlled dermal coagulation.
The system ( RAAS ) is an enzymatic cascade functioning in a paracrine and autocrine fashion.
The systems biology field in aging research is at its infancy.
The systems biology of stress response signaling thus provides a new approach to the understanding and potential treatment of age-related diseases.
The systems biology paradigm integrates experimental biology with accurate and rigorous computational modelling to describe and foresee the dynamic features of biological systems.
The systems science approach builds shared knowledge among an interdisciplinary research team about the dynamics of access to opportunities for oral health promotion.
The systems tested increased the sense of safety and security and helped to postpone institutionalisation.
The system utilizes a single element ultrasound probe with intelligent measurement algorithms to ensure accurate evaluation of local arterial compliance without an image.
The system was installed on a complex continuous care unit at the entrance to @number@ patient rooms and a utility room.
The system was tested by twenty-nine older users and data collected by the insoles were compared with standardized functional tests with a concurrent validity approach.
The system was validated in an independent sample of @number@ participants.
The systolic blood pressure and pulse pressure were significantly greater in patients ≥ @number@ years.
The systolic tension is directly correlated with the pulse pressure and indirectly with the diurnal index. ( r = @number@ ) .
The T1- and T2-weighted images revealed that the increase was attributable to tissue with fat density , not fluid.
The T1DM model was induced with an intraperitoneal injection of streptozotocin.
The T2 relaxation times of the human brain followed a U curve both globally and regionally in both white and gray matter.
The T2s of N-acetylaspartate , total creatine , and total choline were @percent@ , @percent@ and @percent@ shorter in elderly than in young subjects.
The T2 -weighted fat fraction was calculated at each TE.
The TA approach was based on the GLCM.
The tagged ICLs are displayed with immunoquantum dots and the inter-lesion distances determined.
The T-A haplotype from rs878950 and rs9525149 revealed significant association with obesity in the Marshfield sample ( P = @number@ ) .
The tailored approach of the study intervention is a strength in improving adherence , as each recommendation is individualized to be acceptable to the participant.
The T-allele of CTSD rs17571 was associated with an increased risk of AD ( p-value @number@ ) in the Rotterdam Study.
The T allele of rs2273773 in men carried a high risk for hyperglycemia.
The TANK-binding kinase @number@ ( TBK1 ) gene has recently been identified as a novel causative gene of amyotrophic lateral sclerosis ( ALS ) .
The tapping rate of each finger did not correlate with the pinch force or tactile sensitivity for the corresponding finger in the elderly subjects.
The target anatomical sites were @number@ breast including @number@ ipsilateral and @number@ contralateral breast lesions and @number@ extra-mammary nodules.
The target antigen of multiple sclerosis remains elusive.
The target area of the ATR is South Dakota and the four surrounding states : Minnesota , Iowa , North Dakota , and Nebraska.
The target blood pressure values found in guidelines are partly based on randomised interventional studies in which different target values have been compared.
The target comprised of @percent@ MVC and @number@ ms.
The targeted intervention improves the prognosis and compliance of therapy in elderly patients with hematological malignant diseases.
The target enrolment number per village is @number@
The target population comprised 30-65 years old residents from the western suburbs of Yasuj.
The target population of interest was constituted of older drivers in the absence of important cognitive or physical disorders.
The target protein PATE1 was chosen and validated by western blotting and immunohistochemistry.
The target sample size is @number@ with at least @number@ pairs of twins aged 65-90 years.
The target serum bicarbonate concentration is normal range and at least @number@ mEq / l for nondialysis-dependent and dialysis-dependent CKD patients , respectively.
The targets for therapy need not be limited to activation of nrf-2.
The targets of co-regulated microRNAs were also selected for computational prediction using miRWalk software and functional analysis by the DAVID software.
The Task Force concluded with recommendations for advancing the field toward better clinical trials.
The task involves the control of a single output variable over time via multiple and uncertain input controls.
The task required the identification of fragmented pictures.
The tasks had two levels of difficulty : easy and hard.
The tasks that young drinkers performed worse were those related to executive functions , in which the prefrontal cortex plays an essential role.
The tasks were administered to @number@ Flemish-speaking , cognitively healthy elderly.
The tasks were performed in single- , dual- , and triple-task contexts.
The tasks were prepared based on theoretical and clinical backgrounds.
The tasks were walking ½ mile , climbing up steps , doing heavy housework , and getting in / out of bed or chair.
The task was functional stability boundary tests at different speeds ( preferred and fast ) .
The tau and Aβ maps both displayed optimal cortical partitions at @number@ clusters.
The tauopathies are a heterogeneous group of neurodegenerative disorders characterized by the shared presence of tau aggregates and neurofibrillary tangles within the central nervous system.
The TBUT and Schirmer test results were compared between different periods and doses.
The Tc1 mouse is mosaic for the human chromosome such that not all cells in the model carry it.
The TCR repertoire is initially formed prenatally , when the enzyme inserting random nucleotides is downregulated , producing a limited diversity subset.
The Teaching Hospital of Montpellier has set up the clinic and uses IP-Soins as an ICT tool.
The team is now well positioned to apply for more federally funded projects , and more trauma clinicians are considering research careers than before.
The tear physiology of the Chinese population may not be the same as in Western populations.
The technical meaning of degeneracy refers to the structural diversity underlying functional plasticity.
The technique approaches midface rejuvenation with reference to both the bony skeleton and the medial malar fat compartment.
The technique has to be chosen considering the balance between faecal continence preservation and disease eradication.
The technique is adjustable , to incorporate potential piercing holes.
The technique is easy , safe to use and has been used effectively for several clinical and cosmetic indications in Indian skin.
The technique led to stable results and only minor , temporary complications , with a high level of satisfaction among patients and surgeons.
The technique of fat grafting is described , along with review of the evidence of fat viability according to the technique used.
The technique preprocesses the green channel retina images with Gabor wavelet transforms to enhance the retinal images.
The techniques of noninvasive facial rejuvenation are forever being redefined and improved.
The techniques used in the study were photoselective vaporization of the prostate , thulium laser prostatectomy , and diode laser prostatectomy.
The techniques used were myography , molecular biology , and immunoblotting.
The techniques utilized to achieve analgesia of the foot and ankle are diverse , multifaceted , and often incorporate ultrasound guidance.
The technique uses a lateral incision with dissection under the orbicularis and anterior to the orbital septum with release of the orbitomalar ligament.
The technique we used ( SUM-lift ) achieved a significant rejuvenation of the midface and the malar festoons.
The technologies alone offer no all encompassing solution as home care and additional environmental interventions are still needed to support ageing-in-place.
The Technology Research for Independent Living Centre is building a database of gait assessments of Irish community-dwelling older people using GAITRite.
The TEE predictions by these DLS models were not significantly different from the room calorimeter measurements ( all P > @number@ ) .
The teeth were assigned to @number@ groups ( n = 8 ) according to resin cement and in vitro aging strategy.
The teeth were randomly distributed into three groups based on adhesives applied.
The teeth were sectioned into 1-mm2 stick-shaped specimens.
The teeth were subjected to OCT imaging and then cross-sectioned and polished.
The TELE group intervention was delivered by videoconferencing over high-speed Internet.
The telehealth intervention was delivered for @number@ months with feasibility and acceptability as the primary outcomes.
The Telephone Interview for Cognitive Status ( TICS ) and the Dementia Questionnaire ( DQ ) were administered within the same assessment wave.
The telomerase enzyme complex maintains telomere length in germline cells and in cancer cells.
The telomeres of most laboratory mice are @number@ to @number@ times longer than in humans , but their lifespan is @number@ times shorter.
The telomeric long noncoding RNA TERRA has been implicated in modulating the structure and processing of deprotected telomeres.
The telomeric @number@'-overhang is crucial for efficient chromosome capping , but its specific role in telomere shortening and in triggering the senescence program is uncertain.
The telomeric repeat amplification protocol ( TRAP ) is a sensitive and accurate PCR-based assay for telomerase detection and measurement.
The temperature of block storage did not alter quality / quantity of the mRNA ( P > @number@ unpaired t test ) .
The temperature of water molecules is directly related to the diffusion coefficient , so that the temperature of cerebrospinal fluid can be measured using DWI.
The templates included a study-specific template created with DTI-TK and the IIT template serving as a standard template.
The temporal and inferotemporal peripapillary VD was different between male and female patients.
The temporal association between improved cerebrovascular function and increased serum vascular endothelial growth factor and erythropoietin concentrations is supportive of shared hypoxia-inducible transcription factor-1-regulated pathways.
The temporal lobe features marked atrophy of white matter during the disease dynamics.
The temporally distinct changes in callosal thickness are likely to be a consequence of varying degrees of axonal myelination , redirection , and pruning.
The temporal order threshold ( i.e. the minimum temporal gap required to report the stimulus order at @percent@ correctness ) was assessed for each individual.
The temporal pattern of ARI ( t ) varied inversely with Pet ( CO ( @number@ ) ) , decreasing with hypercapnia.
The temporal quadrant cpRNFL thickness measured using the @number@ instruments was positively correlated with the axial length.
The temporal region has imprecise limits in the young patient.
The temporal resolution of attention is known to limit attentional tracking of one and multiple targets ( Holcombe & Chen , @number@ ) .
The temporal resolution of ERPs provided an opportunity to address this issue.
The temporary fillers such as hyaluronic acid and collagen are completely degraded by the surrounding tissue in a few months.
The tendencies toward higher prevalence of diabetes and metabolic morbidity in the adult Greenlandic Inuit population may also be present in the Inuit children population.
The tendency for an increased mitochondrial substrate sensitivity after simvastatin treatment could be an early indication of the negative effects linked to statin treatment.
The tendency in both age groups was to sit with a backward tilted pelvis and a kyphotic trunk.
The tendency to seek stimulating activities and intense sensations define excitement-seeking , a personality trait akin to some aspects of sensation-seeking.
The tenderness with PS at @number@ d postmortem was similar with that of AS at @number@ d.
The term \ "bystander effects \ " refers to changes in naïve cells sharing the same milieu with cells that have been damaged.
The term deprescribing has been utilised to describe the complex process that is required for the safe and effective cessation of inappropriate medications.
The term ' driving self-restriction ' is used in the road safety literature to describe the behaviour of some older drivers.
The term frailty describes an age-related state of vulnerable health.
The term frailty is used to denote such persons , who are more vulnerable to poor health outcomes when challenged by a health stressor.
The term ' frailty ' is used to refer to the state of ' predependence ' in elderly people.
The terminal step of sialylation often affects channel activation and inactivation kinetics.
The term interlaminar was coined to differentiate these processes from the classical astroglial stellate , intralaminar ones.
The term laminopathies defines a group of genetic disorders caused by defects in the nuclear envelope , mostly the lamins.
The term ' nephrosclerosis ' is still an easy way out to classify a patient with renal insufficiency.
The term ' Neurofibromatosis ' ( NF ) comprises a group of rare diseases with related clinical presentations but distinct genetic conditions.
The term ' oral microbial homeostasis ' is used to describe the capacity of the oral ecosystem to maintain microbial community stability in health.
The term prediction implies expected outcome in the future , often based on a model and statistical inference.
The term presbyphagia refers to all changes of swallowing physiology that are manifested with increasing age.
The terms and language of the tools need to be adapted to local contexts.
The term sarcopenia refers to the loss of muscle mass that occurs with aging.
The term \ "saropenia \ " was coined by Irwin Rosenberg in @number@ to refer to age-related loss of skeletal muscle mass.
The terms ' deoxycholate' , ' deoxycholic acid' , ' ATX-101 ' and ' injection lipolysis ' were used.
The terms of reference are different from those of an acute hospital.
The tertiary structure and the microenvironment of the cysteine residues were significantly altered by acetylation.
The tested formulations were green tea gel , black tea gel , @percent@ caffeine gel , carbomer gel base , and a control.
The test for statistical interaction was significant ( P = @number@ ) .
The testing of didactic knowledge before and after the GEMC educational intervention had high internal reliability ( @percent@ ) .
The test is also fruitful for studies on visuospatial organization and its facilitatory and inhibitory mechanisms.
The testosterone / estrone ratio is also the main predictor of ghrelin levels in women ( p = 0.006 ) .
The testosterone of men in industrial societies peaks in their twenties and tends to decline with increasing age.
The testosterone response to the W19 protocol was significantly higher in young than in elderly men ( p < @number@ ) .
The test-retest and interrater reliabilities for SPV measurements in standing subjects were good.
The test-retest correlation for the total SIB score and subscale scores were significant.
The test-retest reliability of the sum of six sedentary activities was @number@ ( @percent@ CI @number@.57-0.81 ) .
The test-retest reliability of the total scale was @number@ sub-scale test-retest reliability ranged from @number@ to @number@
The test-retest reliability showed the results were clinically unreliable.
The test-retest reliability was calculated using the intraclass correlation coefficient ( ICC ) .
The test-retest reliability was satisfactory , with all intraclass correlation coefficients greater than @number@
The test-retest reliability was strong ( r = 0.88 ) .
The test-retest reliability was ρ = 0.961 and ρ = 0.943 for the distress of the caregiver.
The test-retest variability seems to be greater in ALS patients compared with normal controls , but this will need to be confirmed in future studies.
The tests assessed general cognition ( Telephone Interview of Cognitive Status ; TICS ) , verbal memory , and category fluency.
The test showed similar areas under the ROC curve to the much longer modified Mini Mental State Examination.
The tests on fortified butter samples showed recovery values of @percent@ for CML and @percent@ for HMF.
The tests were conducted in a surround-screen virtual reality system , which simulated a narrow plank at elevation on a construction site.
The test was found to be sensitive to the effects of aging and was well tolerated by our sample of older adults.
The test was unaffected by age and education and showed good reliability and discriminant validity.
The TET2 level is regulated by interaction with IDAX , originating from TET2 gene fission during evolution , and by the microRNA miR-22.
The text also highlights important details with respect to patient care , endoscopic equipment , and surgical anatomy.
The text-based format of e-mail might also help older adults mitigate hearing impairments and associated depressive symptoms.
The text is provocative.
The texts of three different Supreme Court cases-in the United States , Canada , and Israel-were analyzed and compared.
The text was limited to English language peer-reviewed articles , resulting in @number@ articles and @number@ books in the analysis.
The TGF-β1-neutralizing antibody could partially reduce the recovery effect.
The Tg mice have increased activity of GLUD , as well as elevated levels and increased synaptic and depolarization-induced release of glutamate.
The Thai dance group had significantly better physical performance in all measurements at the end of the study.
The Thai dancing group exercised for @number@ minutes three times a week for @number@ weeks.
The Thai forensic DNA community is built around it in terms of instrument , databases , and interpretation.
The Thai subjects consisted of @number@ men and @number@ women.
The thalamus , putamen , caudate and pallidum of @number@ participants across the adult lifespan ( ages 20-79 years ) were automatically segmented.
The tHcy-AD link may be partly explained by serum holoTC.
The thematic analysis was informed by the Transtheoretical Model , the Health Belief Model and Social Cognitive Theory.
The themes and issues identified by this study may help guide sexual health-related interventions for older HIV-infected women.
The themes are analyzed in terms of content , frequency , co-occurrence , and dementia severity.
The themes of Age and Brain emerged from the data based on qualitative content analysis.
The themes reported in this article are ' understanding of pain ' and ' perceptions of ageing'.
The theoretical and practical implications and contributions of this study are then discussed.
The theoretical and practical implications of the findings are discussed.
The theoretical and practice implications of these results are discussed.
The theoretically driven and transformative nature of these interventions create special demands for the use of theory in evaluations.
The theoretical model selected to assess the impact of the NB on organizational behavior was Burke's system theory of organizational change.
The theoretical perspective presented here allows for a critical examination of the widely held belief that aging entails the selective disruption of particular memory processes.
The theories also make predictions regarding the nature of biological aging mechanisms and therefore suggest research directions.
The theory coding scheme ( TCS ) was used to assess the extent of theory use.
The theory made Erikson a pioneer in developmental psychology.
The theory of cognitive reserve attempts to explain why some individuals are more resilient to age-related brain pathology.
The theory of cognitive reserve has been proposed for further understanding of interindividual differences in terms of compensation despite the presence of pathological lesions.
The theory of planned behavior was used as a framework to explain the role of the emerged factors in the occurrence of self-medication behavior.
The theory was generated around the core explanations provided by participants and Chinese elders ' concerns about health issues they face in their daily life.
The therapeutic action and pharmacological strategies of anti-AGE agents that can inhibit or prevent AGE formation in the eye are also discussed.
The therapeutical use of secretome is safer and more reliable and offers manufacturing , handling and transportation advantages.
The therapeutic and cosmetic applications of compound @number@ need further investigation.
The therapeutic interventions targeting the mitochondrial-related apoptosis and ER stress responses might be promising strategies to conquer paclitaxel resistance.
The therapeutic potential of resveratrol , diet and the roles of stem cell therapy are discussed to provide a better understanding of the ageing mystery.
The therapeutic potential of αBC alone or in combination with αA-crystallin has been reported.
The therapeutic usages of botulinum toxins now include multiple specialties and multiple indications.
The therapists noted that the intervention was easier to implement with patients who were motivated and had minimal cognitive impairment.
The therapy density ( number of performed therapies per patient ) was determined for every patient.
The thermal effects of monopolar and bipolar radiofrequency ( RF ) have been proven to be beneficial in skin tightening.
The ThermiTight probe temperature was set between @number@ to @number@ °C and was maintained using the thermistor integrated electrode.
The thermodynamic principle of substance stability predicts the existence of a single genetic code in our universe.
The thermodynamics and kinetics vary from linear peptides adopting straight β-strands in fibrils to longer peptides adopting in parallel U shaped conformations in fibrils.
The thermodynamic theory of origin of life , evolution and aging is the development of Clausius-Gibbs thermodynamics.
The thermodynamic theory optimizes physiology and medicine and recommends antiaging diets and medicines.
The thickening of the SC with age compensates for the decrease of the quantity and ordering of the lipidic cement.
The thickest choroid was located at the point superior to the fovea , not the fovea itself.
The thickness of @number@ ligaments was determined at the L4-L5 and L5-S1 levels from MRIs.
The thickness of skull at the anterior midline can be predicted by a simple linear regression equation : A = @number@ + @number@.014 age.
The thickness of the circular layer of muscularis proper was more affected by aging than the longitudinal one.
The thickness of the ligamentum flavum was measured histologically.
The thickness of the stratum corneum and epidermis were measured by microscopy.
The thickness , Young's modulus of elasticity and ultimate strength limit were the main observed parameters.
The thioesterase glyoxalase II ( Glo2 ) can limit protein S-acetylation , thereby preventing subsequent lysine N-acetylation.
The third aim acknowledges the substantial gap between recommended and actual fibre intakes in many developed countries including the USA and the UK.
The third are clinical and imaging studies of mild cognitive impairment.
The third beer contained traces of carbon dioxide bubbles , was light brown and slightly bitter , with an original extract @number@.4° Plato.
The third factor , positive value , was less consistent across the age groups ( α < 0.66 ) .
The third-generation SERM bazedoxifene ( BZA ) effectively prevents osteoporosis while preventing estrogenic stimulation of breast and uterus.
The third , grounded in analogous professional practices , might serve as a potential justification if several controversies can be avoided.
The third group included 8oxoG , A paired with 8oxoG , T at CpG site and hypoxanthine ( Hx ) and displayed poor repair.
The third is the mean vintage ( FDA approval year ) of outpatient and inpatient prescription drugs.
The third module , quantitative differential expressed gene ( QDEG ) , can be used to identify differentially expressed genes.
The third one concerned the motives for purchasing functional food and included the consequences and values.
The third paragraph includes the sentences that should have been removed.
The third part reports on very aged subjects , who display frequent systemic or local diseases.
The third session featured a reception to celebrate the artwork and new friendships.
The third study ( n = @number@ ) examined the test-retest reliability of the test over a period of @number@ month.
The third theme concerned the factors of technology adoption among older adults.
The third theme , the design of AT devices , involves the subthemes individual approach , affordability and safety.
The third treatment was performed @number@ weeks after the second treatment.
The third type of IgM memory B cell is a by-product of the germinal center reaction.
The thoracic kyphosis angle increased by @number@.2° ( p = @number@ ) annually in the GMFCS level IV-V group.
The thoracic / lumbar angle ratio ( T / L ratio ) was used as an index of sagittal balance.
The three age groups were similar in terms of anthropometric measurements.
The three challenge manipulations induced different compensatory speed adjustments.
The three definitions of low appendicular skeletal muscle and the EQ-5D-3 L-Korean descriptive system were applied to Korean older people.
The three-dimensional net knee joint forces , moments , and angles were calculated using typical inverse dynamics.
The three-dimensional raster scan protocol was used to construct a choroidal thickness map.
The three dimensions showed good reliability and stability.
The three follow-ups were summarized into long-term alcohol consumption.
The three groups were compared in regard to symptoms , esophageal motility , and health-related QOL ( HRQOL ) .
The three groups were compared statistically with regard to pancreatic stiffness.
The three identified components of health offer opportunities for an integrated approach to deal with the health care needs of older citizens.
The three interventions increased metacarpal BMD and reduced the incidence of hip fractures.
The three leading motivating factors for both women and men were to prevent health problems , to feel good and to lose weight.
The three main labile blood products used in transfusion are erythrocyte concentrates , platelet concentrates and fresh frozen plasma.
The three main themes identified in the caregiver interviews were the experiences of caregivers , the rewards of caregiving , and navigating the caregiver role.
The three memory subtasks adopted the same retrieval paradigm and were matched for initial difficulty.
The three most abundant proteins in mammalian endocytic CCVs are clathrin and the two cargo-selecting , clathrin adaptors , CALM and AP2.
The three most common health conditions were hypertension ( @percent@ ) , eye diseases ( @percent@ ) and coronary artery disease ( @percent@ ) .
The three objective criteria proposed by Rowe and Kahn were operationalized using a six-item summed score.
The three-part protein fractions from the individual lenses were combined to form the total proteins of each sample.
The three projects described in this paper provide a unique pan-European research field to further study implementation efforts and outcomes of new technologies.
The three remaining clusters had intermediate results , significantly different from the normal and complex infarct clusters but not usually from one another.
The three SM pillars are highly interconnected , and their balancing is crucial.
The three tasks were completed first in the subjects ' imagination and then in reality , with time required as the dependent measure.
The three TERC single nucleotide polymorphisms are in strict linkage disequilibrium and their genotype combinations influenced the age at AD onset ( AAO ) .
The three top-ranking markers , which are located in the genes DUSP6 , NALP1 and PERP , revealed p-values≤0.01 in the allelic case-control comparisons.
The three years of MACVIA-LR activities are reported in this paper.
The threshold for the response in the early responders was @number@ years old.
The threshold for the response of the nonearly responders was @number@ years old.
The threshold level was higher in men with sexual dysfunction.
The thresholds elevated and the amplitudes decreased in both examinations with the age growing.
The threshold volume to elicit PGCR , PUCR , and RPS was significantly lower than the HPSV during rapid injections.
The thymus atrophies rapidly with age , resulting in progressive diminution of new T cell production.
The thymus is a central lymphoid organ critical for the development and maintenance of an effective peripheral T-cell repertoire.
The thymus is an excellent example of the connection between cellular organization and organ function.
The thymus is a primary immune tissue which is essential for overall immune function.
The thymus is primarily responsible for T cell production.
The thymus is the organ devoted to T-cell production.
The thymus is the primary organ responsible for de novo generation of immunocompetent T cells that have a diverse repertoire of antigen recognition.
The thymus undergoes multiple rounds of atrophy and redevelopment before degenerating with age in a process known as involution.
The thyroid prominence was significantly more anteriorly angulated in males.
The thyroid RAIU was determined at 24h and @number@ h.
The tibiofemoral contact mechanics of @number@ cadaver knees were investigated using a custom dynamic loading apparatus , pressure sensor , and motion sensing camera.
The tIFR was not associated with serum hsCRP level.
The tight evolutionary conservation and ubiquitous expression of prohibitin proteins suggest a similar role for the mitochondrial prohibitin complex during aging in other organisms.
The tight link between affect and cognition is discussed.
The TI in the oxazepam-induced coma was @number@ the largest dose.
The time between baseline and follow-up scans was @date@ weeks after the commencement of ADT.
The time constant of cone recovery was determined by fitting an exponential model to the amplitude recovery data.
The time constants for the activation and inactivation of sodium currents were smaller in adult atria than pediatric atria.
The time course of fluency performance was characterized in terms of slope and intercept parameters and related to neuropsychological constructs.
The time cycled increased with higher temperature.
The ' timed up and go' , ' 30-second chair stand' , ' handgrip ' and ' Romberg balance test ' were all performed.
The Timed Up and Go test was performed preoperatively.
The timed up-and-go test was used to measure functional mobility , and the 6-minute walk test was used to measure functional performance.
The Timed Up and Go ( TUG ) test was performed before and after the training.
The Timed Up and Go ( TUG ) test was used to assess functional balance.
The time-frequency structure of force output fluctuations was only significantly affected by task conditions.
The time-honored point of view is that LLC itself , or its increment , causes LBP.
The time interval between the onset of symptoms and diagnosis was @number@.1-120.0 months.
The time it took for the shunts to fail was between @number@ and @number@ years ( mean @time@ ± @number@ years ) .
The time needed to complete the CAT was compared to that needed for the whole CAMCOG and CAMCOG-Plus.
The time period of data collection ranged from @number@ to @number@ years.
The time required to complete and score the PACSLAC-II was reasonable , supporting its usefulness in clinical settings.
The @time@ sample correlated strongly with the total 24-hour secretion , explaining two-thirds of the variability.
The times to diarrhea resolution were similar for cadazolid and vancomycin.
The time structure features of the three categories of movements considered in this study were found to be clearly different.
The time taken by participants to use each HAS was also collected.
The time taken to rise from a chair @number@ times and standing balance time were assessed during home visits at the same age.
The time taken to walk was measured.
The time to complete the chair stand test was similar from @number@ to 40-44 years , and declined progressively across subsequent age groups.
The time-to-death metric showed more evidence of dedifferentiation , with four of the seven tests exhibiting dedifferentiation.
The time to interview African American and Afro-Caribbeans was greater than the time needed to interview Hispanic American and European American participants.
The time trends for ADL disability found in the study show that ADL disability had increased in women but not in men.
The time variable ( in years ) was not significant ( odds ratio = @number@ @percent@ confidence interval = @number@ to @number@ ) .
The time-varying covariation between cognition and inconsistency was significant across the 1-year intervals and remained stable across both time and age.
The timing and magnitude of the EMG responses were compared between the two age groups.
The timing of BBB breakdown remains , however , elusive.
The timing of night-time sleep was determined from the cessation and re-occurrence of daytime-level activity.
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases.
The timing of repair remains controversial , and most reports do not delineate morbidity of emergent presentation.
The timing of the intervention could be improved by scheduling it immediately after the move.
The timing of this issue of Healthcare Papers is important : the first of the baby boomers turned @number@ in @date@ .
The TIMP-1 level declined with age but increased in chronic smokers when compared to ONS.
The tissues of the lungs undergo changes with age that lead to an increase in alveolar size without any destruction of alveolar walls.
The tissues were decellularized to prevent immunological rejection.
The tissue was paraffin embedded and processed.
The tissue was routinely processed , embedded and serially sectioned.
The tissular elastin content decreases during chronological aging , and the mechanisms underlying its slow repair are not known.
The title of the presentation was \ "Enhancing End-of-Life Care for Prisoners Through Partnering With the Prison Community. \ "
The TKA and UKA studies included an older population , with mean ages ranging from @number@ to @number@ years.
The TLSA sample comprised two cohorts : @number@ persons aged @number@ years and over in @number@ and @number@ persons aged 50-66 years in @number@
The TM acts as a molecular sieve , providing resistance to aqueous outflow , which is responsible for regulating intraocular pressure ( IOP ) .
The TM cells were positive for TLR4 , ABCB1 , and CYP3A5 and were negative for the ABCC1 transporter.
The TMEM106B genotype has also been found to be a modifier of the age at disease onset in frontotemporal dementia patients with TDP-43 pathology.
The TMEM106B variants were associated with lower level of DNA methylation in an active enhancer in GRN.
The Tm of AGE-α-synuclein-scDNA complex is more than that of native α-synuclein-scDNA complex , indicating that AGE-α-synuclein stabilized the uncoiled scDNA.
The TMPG reagent specifically reacted with guanine moiety in DNA at room temperature and provided CL intensities.
The T normalized for Dx ( T / Dx ) of each dot is a measure of telomere content.
The Toddler NutriSTEP questionnaire is both reliable and valid for screening for nutritional risk in toddlers.
The TOJ thresholds of the sleep deprived were comparable to those of the aging adults , but their pattern of speech performance differed.
The tolerability is high for low dosages , with some gastrointestinal complaints appearing to be associated with use of high dosages.
The ToL score was calculated according to the Krikorian method and also the execution time was measured.
The tonsils provide defense of the upper aerodigestive tract against pathogens.
The tool can be used along with its caregiver version to provide useful feedback ( via monitoring of symptoms ) for modifying care plans.
The tool can be used as a predictor and / or indicator of successful aging and life quality of seniors.
The tool is also simple to use by a non expert and can therefore be widely used on a large set of patients.
The tool is freely made available at @url@
The tool is free to the community and forms a base for data contributions to augment the model and its future use in practice.
The tool is most likely unable to deliver as good a performance in terms of discriminating between different disorders.
The tool may help tailor individualized diagnostic and preventive care decisions.
The tool smooths , cleans and equalizes fiber intensities in the image before segmenting the fibers into a binary image.
The tool summarized evidence to address their needs and enabled women to monitor actions taken.
The tool supplies standardized information upon admission allowing more time to work with high-risk admissions.
The tool used was a questionnaire.
The tool was sensitive to change and was found to be reliable when used by different raters.
The top BP signature genes in aggregate explain 5%-9% of inter-individual variance in BP.
The top five clinical indications for stem cell therapy were multiple sclerosis , anti-ageing , Parkinson's disease , stroke and spinal cord injury.
The top five funded institutions represented @percent@ of all funding.
The topical application of prescription and non-prescription agents ( cosmeceuticals ) can provide additional benefits.
The topic of gastroenterology ( GI ) in the elderly has been extensively reviewed.
The topic of medical travel-going abroad to seek medical care-has been widely reported in various news outlets.
The topics were analyzed by the software SPSS using the Spearman correlation.
The top networks for genes differentially expressed with tendon age were from cellular function , cellular growth , and cellular cycling pathways.
The topographical pattern of amyloid deposition and its impact on clinical status in pure subcortical vascular cognitive impairment were different from those in Alzheimer's disease.
The topographic distribution of dVRS is not uniform within the brain and may depend on anatomic or pathologic characteristics interacting with aging and sex.
The topography of cortical thinning related to WMH was distributed in the frontal and perisylvian regions , which was similar to that of PWMH.
The top selling products and their ingredients were then identified from individual brand websites.
The top six most frequently used classes of medications were gastrointestinal agents , antihypertensives , diuretics , analgesics , β-adrenoceptor antagonists and antihyperlipidaemics.
The top three chronic diseases included : high blood pressure ( @percent@ ) , diabetes ( @percent@ ) , and asthma ( @percent@ ) .
The top three classes of medications involved in polypharmacy were antithrombotics , peptic ulcer disease and gastro-oesophageal reflux disease agents , and ACE inhibitors.
The top three motivations for BDS users were to improve overall health , to maintain health , and to supplement the diet.
The torque recorded in the antagonist muscles was estimated using a biofeedback technique.
The total 5-year incidence was @percent@ for diabetes and @percent@ for prediabetes.
The total absence of photoactivation may still impair their mechanical properties even after short-term aging.
The total adenine nucleotide pool and ATP content of EV71-infected cells significantly diminished.
The total antioxidant content and UV absorbing properties of various commercially available ophthalmic solutions used to alleviate dry eye symptoms were also examined.
The total center of pressure ( COP ) path length displacement served as standing balance performance outcome.
The total cost for each participant ranged from $ 265 to $ 576.
The total cost of providing hospice rose dramatically , increasing from $ 1.98 million in @number@ to $ 5.91 million in @number@
The total cost of smoking for this community amounted to $ 1.4 billion ( @number@ dollars ) or $ 1.9 billion expressed in @number@ dollars.
The total cost of the two procedures was determined.
The total cross-sectional choroidal area , luminal area , and stromal area of the choroid were measured.
The total drusen area was measured using ImageJ™ software.
The total genes of the @number@ groups were compared by DNA microarray analysis.
The total healthcare costs of SHS exposure in rural China accounted to @percent@ of China's national healthcare expenditures in @number@
The total intracranial volume and C3 vertebra dimensions showed the highest correlations with cord measures.
The total IUI history ( @number@ cycles ) of @number@ couples was studied.
The total number of AciI sites in the analyzed fragments ranged from @number@ to @number@ for different genes.
The total number of completed CBE-OUT checklists was @number@ ( Finland , @number@ Poland , @number@ and Spain , @number@ ) .
The total number of elderly persons with gastric ulcers in Japan is increasing with an improvement in the average life expectancy.
The total number of falls in both groups was recorded by following up subjects ' diaries and telephone interviews at @number@ @number@ and @number@ months.
The total number of incident dialysis patients was projected to increase by @percent@ from @number@ @number@ in @number@ to @number@ @number@ in @number@
The total number of medications and xerogenic medications did not play a significant role in xerostomia.
The total number of NPS and symptoms of hyperactivity , psychosis , affect and apathy were evaluated.
The total number of peptides identified increases rapidly across the first three PIE iterations and then continues more slowly up to nine iterations.
The total number of risk assessments completed from @number@ to @number@ exceeded @number@ @number@ @number@
The total number of smokers was summed to determine resulting smoking prevalence.
The total number of studies included in this systematic review was ten.
The total number of treatments received ranged from @number@ to @number@ ( mean @time@ ) .
The total number of unweighted sample size was @number@ participants : @number@ men and @number@ women , and OA prevalence was @percent@ and @percent@ respectively.
The total number was increasing year by year.
The total ONH ( papillary and peripapillary ) area VD was @number@.03%±4.55%.
The total Oxygen Radical Antioxidant Capacity ( ORAC ) of @number@ ARF reported by subjects was estimated using published values.
The total phenolic and flavonoid contents of GEB were @number@ and @number@ mg / g dry weight ( DW ) , respectively.
The total phenolic content and individual phenolics in RPP were determined.
The total phenolic content ( gallic acid equivalent ) of the VRF is @number@ mg per g of dry mass.
The total projected growth in required inpatient capacity is @percent@ , accounting for both number of admissions and length of stay.
The total sample consisted of @number@ individuals aged 50-75 years ( @percent@ men , mean age @number@ years ) at baseline ( @date@ ) .
The total sample consisted of @number@ young-stroke patients with a mean age at follow-up @number@ ( SD = 10.3 ) .
The total sample size was @number@ subjects.
The total scale and subscales showed excellent internal consistency.
The total score of sexual attitudes showed significant differences depending on gender and availability of sexual activity.
The total score recorded by both examiners , interclass correlation coefficient , was @number@ which is excellent.
The total scores and three subtests of the LOTCA-G revealed significant differences after the intervention.
The total SIB score and subscale scores were examined according to CDR.
The total sleep time and the numbers of short , normal , and long sleepers were similar at baseline and at @number@ years later.
The total study duration for each patient is @number@ weeks ( @number@ months ) .
The total subiculum and the total dentate gyrus volumes were associated with age , while the total cornu ammonis 1-3 was not.
The total surface area of the holes within the fabric was measured.
The total sway path was calculated for all tasks.
The total WMH volume increased @number@ ± @number@ ml / year , mainly through enlargement.
The touch-screen technology was also well accepted by elderly people and can be used as a kiosk for disseminating nutrition education for healthy aging.
The toxic effects that stem from the misassembly or aggregation of proteins or peptides , in any cell type , are collectively termed proteotoxicity.
The toxicity of Aβ ( 25-35 ) positively correlated with both the erythrocyte age andthe peptide concentration.
The toxicity of carbon nanotubes ( CNTs ) has received significant attention due to their usage in a wide range of commercial applications.
The toxicodynetic parameters were assessed as previously described.
The TP53 gene encodes @number@ distinct isoforms , some of which can alter p53 activity in the absence of genomic alteration.
The TP task was paired with an elemental control task , which does not depend upon the hippocampus.
The TPV growth rate was correlated negatively with baseline TPV ( r = -0.32 , P < 0.001 ) .
The trabecular bone specimens from the medial compartment of the proximal tibial metaphysis were examined.
The tract-based analyses revealed no significant ApoE effects , and no significant interactions between genotype and age were observed.
The tradeoff appears to be plastic , in that only highly trained athletes experience the tradeoff.
The traditional approach to normative data creation is to make demographic adjustments based on observations of correlations between single neuropsychological tests and selected demographic variables.
The traditionally accepted associations of adult adenomyosis , such as multiparity , a link to infertility and its effect on pregnancy are uncertain.
The traditional rhytidectomy addresses facial and neck aging as it relates to soft tissue laxity.
The traditional risk factors were strong risk factors for gout and hyperuricemia in China.
The traditional trust patients have in physicians provides an important base on which to build.
The traditional TUG was conducted while subjects wore a body-fixed sensor.
The traditional view is that this secretory pattern is driven by two counter regulatory neurohormones , GHRH and somatostatin.
The TRAF2-GSTP1-1 complex was constitutively present in U-2OS cells , but strongly decreased in S , G2 and M phases.
The training combines the expertise of geriatric psychiatry , geriatric care , and educational psychology.
The training effect on the reasoning and speed of processing outcomes did not differ by BMI status.
The training effects often transfer to untrained tasks and functions.
The training effects were mainly driven by the low-capacity individuals who improved in all trained tasks.
The training group completed five sessions of cognitive dual-task training spaced at least @number@ days apart.
The training group participated in six dorsiflexor exercise training sessions between test and retest.
The training groups received @number@ sessions of executive process training for about @number@ min / session during @number@ weeks.
The training group was divided via median split in high- and low-capacity individuals to determine the influence of baseline WM capacity on training gains.
The training intervention consisted of a dual n-back task including independently processed auditory and visual n-back tasks.
The training produced a benefit in both the criterion and transfer tasks , which was maintained at follow-up.
The training program for both experimental groups included exercises that required high-speed concentric muscle actions.
The training program had positive impacts at both individual and organizational levels.
The training program induced an increase of phospho-extracellular signal-regulated kinases @number@ and @number@ ( ERK1 / 2 ) and Hsp70 and a reduction of Hsp60.
The training regimens were progressive in nature , with increases in training intensity and duration occurring throughout the 8-week period.
The training was evaluated with a pre-post-control group design and time-series analyses.
The trajectory analysis suggested that increased rates of TDP-43-associated hippocampal atrophy might occur at least @number@ years before death.
The trajectory-based spatial parameters during the TUG test were measured using an LRS.
The trajectory of cognitive function and risk factors for cognitive decline remain uncertain in this population.
The trajectory of the hyoid bone in sagittal section indicated the capability of swallowing , and may detect some anomalies in swallowing.
The trajectory , or slope , of cognitive decline may provide differentiation of older adults with and without incipient neurodegenerative disease.
The transconjunctival approach to lower lid blepharoplasty provides access for both fat resection and transposition to soften tear trough deformities and correct infraorbital fat herniation.
The transcribed interviews were content analyzed , involving qualitative description , and thematic analysis techniques.
The transcriptional activity of the Prdm13 promoter was upregulated by Nkx2-1 , and knockdown of Nkx2-1 suppressed Prdm13 expression in primary hypothalamic neurons.
The transcriptional coactivator PGC-1α has emerged as a key driver of metabolic programming in skeletal muscle , both in health and in disease.
The transcriptional corepressor SMRT utilizes two major receptor-interacting domains ( RID1 and RID2 ) to mediate nuclear receptor ( NR ) signaling through epigenetic modification.
The transcriptional regulation of mitochondrial biogenesis by normal metabolic adaptation or injury has been clarified over the past decade.
The transcription factor activator protein-1 ( AP-1 ) participates in many aspects of cell physiology , such as cellular proliferation , transformation , and death.
The transcription factor ATF-7 was identified in both ethylmethanesulfonate mutagenesis and candidate gene screens.
The transcription factor binding site prediction program PROMO predicted the disruption of three transcription factor binding sites in this enhancer region.
The transcription factor NF-E2 p45-related factor ( Nrf2 ) induces the expression of cytoprotective proteins that maintain and restore redox homeostasis.
The transcription factor NF-E2-related factor ( NRF2 ) is a key regulator of several enzymatic pathways , including cytoprotective enzymes in highly metabolic organs.
The transcription factor Nrf2 serves as the master regulator of a highly coordinated antioxidant response in virtually all cell types.
The transcription of certain mitochondrial genes may depend on the redox potential of the mitochondrial membrane.
The transcription of miR-7 was found to be upregulated in aged cells.
The transdermal penetration test in the rat using two types of fluorescein indicated that maceration disrupted skin barrier function.
The transducer was placed in a longitudinal scan above the larynx.
The transeyelid approach to midface lift is an elegant approach for mild descent of malar soft tissue.
The transformation focused on clearly defining the role , function and reporting structure , and identifying which healthcare providers could fill the liaison role.
The transformation of CNTs in the atmosphere , resulting in their functionalization , may significantly alter their toxicity.
The transformation of senile dementia into AD can diminish , as well as reinforce , stigmatization of people with AD.
The transfusion of red blood cells ( RBCs ) is now considered a well-settled and essential therapy.
The transgenic lines exhibit unique effects in proteostasis.
The transgenic rats developed progressive age-dependent neurofibrillary degeneration in the cortical brain areas.
The transient nature of subtle degrees of thyroid dysfunction in a significant proportion of elderly patients has also been reproduced in the recent publications.
The transition from adolescence to adulthood is a critical stage in the human lifespan during which the brain still undergoes substantial structural and functional change.
The transition from community dwelling to a nursing home is a common , though idiosyncratic , experience in the United States.
The transition from fetal to adult beta-like globin expression is a key step in the maturation of the red blood cell lineage.
The transition of long-term quiescent fibroblasts into senescence is also independent of HES1 which protects short-term quiescent cells from becoming senescent.
The transition program was subsidized by the healthcare ministry and enabled @number@ projects throughout the Netherlands.
The transition rate from MCI to AD was @percent@.
The transition to an \ "alternatively \ " activated M2 phenotype encompasses neuroprotection and repair.
The transition to irreversible phase @number@ dysfunction remains to be characterized , but may be related to increased reactive oxygen species ( ROS ) production.
The translational activity of CUGBP1 is activated by dephosphorylation at Ser302.
The translation of the frailty concept by means of physical performance measures implicitly represents an attempt to go beyond traditional paradigms.
The transplantation procedure ( Tx ) was performed between @number@ and @number@
The transport of pyruvate into mitochondria requires a specific carrier , the mitochondrial pyruvate carrier ( MPC ) .
The transport rate was @percent@.
The transport substrates and acceptors were identified in BHK / ABCA7 cells and compared with those of ABCA1.
The transverse relaxation rate is computed as a function of these parameters.
The traverse frequency was strongly reduced by inactivation of the translocase and DNA binding activities of the FANCM / MHF complex.
The treadmill running group had the lowest proportion of MHCIIL and the greatest proportion of MHCIIx isoforms.
The treated areas are : face , neck , eyebrows , abdomen , legs and buttocks.
The treating physical therapist then used a 7-point Likert scale to rate the participants ' change in function.
The treating physician ( s ) reported no post-treatment adverse events.
The treatment achieves satisfactory volume correction , enhancing the sharp cheek bones and malar fullness typical of an attractive adult face.
The treatment also induced the nuclear translocation of RelB without the processing of p100 to p52.
The treatment alternatives providing the most advantageous cost / outcome combinations were identified according to the net benefit criterion.
The treatment and monitoring of osteoporosis should be continued without important amendments because of the presence of T2D.
The treatment and prevention of AD and other dementias , therefore , is an urgent unmet need.
The treatment appeared to be more effective in younger patients , probably because their fibroblasts are more prone to synthesizing collagen.
The treatment applied consisted of antibiotics , oral rinses with chlorhexidine , drug discontinuation and surgical procedures.
The treatment applied to each side of the face was reversed in Cycle @number@
The treatment by gases was used : hyperbaric oxygenation , dry carbonic acid baths , ozon therapy , hypo oxygen therapy and their combinations.
The treatment challenges in managing Sheehan's syndrome and psychosis are discussed.
The treatment course consisted of three once-a-week sessions.
The treatment decision is complicated by considerations of haemorrhage risk , with factors that increase risk of stroke also associated with increased risk of haemorrhage.
The treatment group also showed significantly increased passive hip extension range of motion.
The treatment has little function damage to patients ' endocrine and external secretion.
The treatment included @number@ MT sessions.
The treatment inequities associated with ethnicity were more pronounced in women than men.
The treatment is mainly based on blocking the renin angiotensin system , especially when proteinuria is present.
The treatment is performed with the aid of a blood-circulating pump.
The treatment led to a paradoxical increase in behavioral activation in the transgenic mice , suggestive of altered functioning of the dopaminergic system.
The treatment may be complicated by co-morbidities and increased risk of toxicities from usual treatments , particularly steroids.
The treatment of both types of patients is common.
The treatment of choice for OSAS is continuous positive airway pressure ( CPAP ) .
The treatment of choice remains surgery or radiotherapy to ensure a good carcinologic control.
The treatment of chronic kidney disease ( CKD ) and of end-stage renal disease ( ESRD ) imposes substantial societal costs.
The treatment of elderly and mostly polymorbid patients is an outstanding challenge in view of the demographic change with a continuously aging community.
The treatment of glabellar lines with botulinum toxin type-A ( BoNT-A ) is a staple for aesthetic providers who specialize in facial rejuvenation.
The treatment of Hodgkin lymphoma is one of the success stories of modern medicine.
The treatment of HUVECs with VEGF leads to a reduced expression of nidogen-1 mRNA whereas its expression remained unchanged in RPE cells.
The treatment of lesions arising in the oral cavity is controversial.
The treatment of most forms of glaucoma includes the use of topical agents that enhance aqueous humour outflow , reduce aqueous production , or both.
The treatment of older HIV-positive patients with cancer requires careful attention to details.
The treatment of pain in patient with fragility fracture is rarely considered a priority in the care pathway.
The treatment of the aging woman , including hormone treatment after menopause , should remain one of our highest research priorities.
The treatment of urinary incontinence can reduce morbidity and mortality.
The treatment regimens received by these patients were highly variable.
The treatment seeking pattern was highly associated with the level of education ( p = @number@ ) .
The treatments included resurfacing of the full face , periocular upper lip , and residual acne scars.
The treatment strategy , in terms of its clinical efficacy and drug safety , in the elderly is presented.
The treatments were given @number@ times per week totally for @number@ weeks.
The treatments were well tolerated by all subjects with no adverse effects.
The treatments were well tolerated with minimal discomfort.
The treatment × time interaction term was significant at p < @number@ FWE corrected.
The treatment was administered to the hands twice daily over an 8-week period.
The treatment was always well tolerated without adverse effects.
The treatment was conducted once daily , @number@ time a week and continuously for @number@ weeks.
The treatment was generally well tolerated and no instances of product migration from the injection site have been reported.
The treatment was given once in a day , six of which made a course.
The treatment was particularly detrimental in people addicted to drugs.
The treatment was performed for the skin in the eye area.
The treatment was performed in one session.
The treatment was well tolerated and adverse effects were limited to transient facial edema.
The treatment was well-tolerated and PIH was not found in our study.
The tree Aquilaria malaccensis is a valuable source of agarwood , which is used in herbal medicinal preparations.
The trend for breast cancer mortality was essentially similar.
The trend of an increasing association between obesity and disability has leveled off in more recent years , and is even improving for some measures.
The trend of increased NRM after ES requires reevaluation in a larger syngeneic HSCT cohort.
The trend of in vivo deposition was consistent with that of the in vitro profiles.
The trend of the coincident cataract and glaucoma is likely to increase worldwide and it is a common finding in the aging population.
The trend scenario provides projections until @number@ based on the trends over the last decades and assuming the policy stays the same.
The trends in neurotransmitter formation differed between G1 and G2 patients after SVR.
The trend to reduction of the sizes of neutrophiles speaks of the accelerated division of predecessors ' of mature neutrophiles.
The tretinoin peel , also known as retinoic acid peel , is a superficial peeling often performed in dermatological clinics in Brazil.
The triage theory proposes that modest deficiency of any vitamin or mineral ( V / M ) could increase age-related diseases.
The trial also explores multiple outcomes to elucidate the potential mechanisms of Tai Chi and aerobic exercise and the generalizability of these interventions across instructors.
The trial assessed information processing speed , short-term memory , spatial relations , concentration , reasoning , and cognitive speed.
The trial duration and accuracy , measures of gross motor function and fine motor control , respectively , were computed for each participant.
The trial has been registered at ClinicalTrials.gov.
The trial is registered in Clinical Trials ( ID : NCT01632072 ) .
The trials were conducted in a single clinic in association with the Hôpitaux Universitaires de Genève , Geneva , Switzerland.
The trial testing the effectiveness of the STRIDE intervention is in progress , with results expected in late @number@
The trial uses a sequential design with a maximum number of @number@ patients to be enrolled ( ISRCTN @number@ ) .
The trial was conducted in @number@ academic medical centers in the United States from @date@ to @date@ .
The trial was registered at clinicaltrials.gov ( NCT01407939 ) .
The trial was registered in ClinicalTrials.gov provided by the US National Library of Medicine-number NCT03175614.
The tribal participatory research ( TPR ) conceptual model suggests modifications to CBPR to fit the special needs of American Indian communities.
The trigeminal nerve gave off @number@ supraorbital and @number@ supratrochlear branches emerging from orbit.
The trisomy @number@ in DS provides an opportunity to study the effect of duplicated genes in AD.
The trophicity of women's urogenital tissues depends on the hormone level and on the quality of the vaginal flora.
The Trp53 gene is involved in meiosis in male rats and mice suggesting that the p53 plays a critical role in spermatogenesis.
The TRST had low to moderate sensitivity ( 42%-67% ) and a high negative predictive value ( ≥82% ) .
The true analogy is a speeding car that enters a low-speed zone and damages itself because it does not and cannot slow down.
The True Grit Program is presented as an example of a humanistic and holistic approach of such an approach.
The true incidence of SCAD is underestimated , as most cases are diagnosed at autopsy.
The trunk angle of the young subjects was more than two times higher than that of the FG.
The truth is that many of these products can be expensive and produce results that do not live up to the claims.
The Ts65Dn is a popular mouse model of Down syndrome ( DS ) .
The Ts65Dn is being used in preclinical evaluations of drugs for cognition in DS.
The t-tau remained stable.
The TTCC , which was a colored cards configuration memory task , was examined for sensitivity and specificity.
The TTC intervention consisted of twenty @number@ min sessions.
The TTE results were equivalent to those of abdominal ultrasound.
The t-Test and the Pearson coefficient of correlation were used for statistical analysis , with a significance level of p < @number@
The TTR achieved with Zeus was similar to that obtained with the PARMA algorithm.
The tuberous sclerosis complex ( TSC ) protein is a negative regulator of mTOR.
The TUG1 / miR-455-3p / AMPKβ2 axis regulates cell growth , metastasis , and glycolysis through regulation of hexokinase @number@ ( HK2 ) .
The TUG was faster after the WEFT training ( p < @number@ ) .
The tumor cells which already have migrated into normal brain tissue beyond the surgical resection margin account for the inability to effectively treat this tumor.
The tumorigenic ability of CSIG was confirmed in vivo in a mouse xenograft model.
The tumor promoter PMA is a gero-promoter , which may be useful to study aging in mammals.
The tumor size was about @number@ mm on CT @number@ months previously , indicating rapid enlargement.
The tumor suppressor p53 is pivotal in cell growth arrest and apoptosis upon cellular stresses including DNA damage.
The tumor suppressor p53 provides exquisite protection from cancer by balancing cell survival and death in response to stress.
The tumor suppressor protein p53 has a variety of roles in responses to various stress signals.
The tumor was diagnosed as a primary malignant mediastinal non-seminomatous germ cell tumor by needle biopsy.
The Turkish version of the KAOP can be considered reliable and valid scale for assessing the attitudes toward older people.
The turning points were analyzed according to principles of the life course theory and narrative analysis.
The two additional specimens were used to assess the model prediction.
The two adults are a resident in a long-term care facility ( Mike ) and a researcher.
The two cultivars had a similar behavior.
The two experimental groups improved in a similar extent ( ∼ @percent@ ) their ability to regain balance during forward falls after the intervention.
The two fillers were not significantly different in safety profile or wrinkle correction during the follow-up visit.
The two graders had a correlation of @number@ with each other.
The two grading scores were positively correlated for both knees-statistically significant only for the right side ( r = @number@ p = @number@ ) .
The two grid pattern handpieces included @number@ mm wide lines with @percent@ and @number@ mm wide lines with @percent@ coverage.
The two groups also differed in freely-generated characteristics of wisdom and its development.
The two groups ( OC users versus non-users ) were comparable regarding age , BMI , smoking and maternal age at menopause.
The two groups of different ages were also divided into dialysis and nondialysis subgroups.
The two groups showed different error patterns.
The two groups showed elevated but similar percentages of senescent T cells.
The two groups were matched by age and years of schooling.
The two groups were matched for sex , age , and cigarette smoking.
The two groups were significantly different ( t = @number@ p = @number@ ) .
The two groups were similar in age at scan date , education , ethnicity , sex distribution , and cognitive performance at first visit.
The two groups were similar in age , education , race and gender.
The two groups were similarly efficient in using the acoustic cues , but there were differences in the patterns of emotion-specific predictors.
The two Korean cohorts were combined.
The two leaflets that make up the bilayer differ in their fluidity , electrical charge , lipid distribution , and active sites of certain proteins.
The two longitudinal studies were small ( @number@ and @number@ subjects ) , covered different age ranges and yielded inconsistent results.
The two methods produced comparable results.
The two methods typically do not provide the same answers.
The two-min step and the eight-foot up-and-go tests were used to evaluate their impact on fitness level.
The two modes of resistance exercise had identical effects on fall risk and fall-free survival.
The two most commonly employed frailty measures are the frailty phenotype and the frailty index.
The two most frequent complications were ill-fitting RDPs and inflammation of the oral mucosa.
The two most frequent complications were ill-fitting RDPs and inflammation of the oral mucosa , followed less frequently by fractures of the clasps.
The two most salient ones were ' external influence ' and ' implication of the partner'.
The two pansystolic time parameters , ejection time compensated ( ETc ) by DPA and LVET by tonometry , showed a significant but weak correlation.
The two polymorphisms showed an addictive effect.
The two population-based endoscopic surveys showed no significant effect of age on reflux oesophagitis prevalence.
The two prebiotics improved intestinal microbiota differently.
The two RCTs demonstrated that multivitamin / mineral supplements could decrease the risk of nuclear cataracts.
The two scores were uncorrelated in the young but significantly correlated in the older group.
The two significant mediators jointly explained @percent@ of the intervention's total effect on functional disability.
The two sources of copper-2 ingestion are drinking water and multimineral supplement pills containing copper.
The two-stage assessment involved both quantitative ( survey ) and qualitative ( discussion group ) components.
The two-stimuli oddball paradigm was used.
The two tasks had similar levels of difficulty.
The two tasks involved making two-choice decisions to visually presented stimuli.
The two tasks were significantly different for both their identification of latent classes and their monthly classification of the infant's hand-use preference.
The two tests showed fair agreement when used to classify people into three categories of stereovision.
The two trends are linked through the fact that changes to the environment affect older adults , and older adults affect the environment.
The two types of bereavement complications share some but not all of the same features.
The two types of problems have been linked together and attributed to a general disturbance of infant regulation.
The two values were also compared between the two groups.
The two views are not mutually exclusive , and we present examples illustrating both aspects.
The two-way ANOVA , showed no significant differences for the interaction between the factors and for the aging factor.
The two-way interaction between age and WM was significant , suggesting that WM effects were greater than age effects on the task.
The two year overall survival rate was @percent@ versus @percent@ respectively ( p = 0.0001 ) .
The TYM-MCI correctly classified most patients who had equivocal ACE-R scores.
The type of damage measured by this assay includes abasic sites , crosslinks , and strand breaks.
The type of Hp gastritis may explain the controversial effect.
The type of loading ( wear versus compression fatigue ) appeared to not affect the oxidation behavior in the studied conditions.
The type of RBC also affected the shear bond strength ( P < @number@ ) .
The types and numbers of oral problems that were experienced were described based on OHIP items with a score of @number@ and @number@
The types of DNA aberrations that arise during aging before tumor development and that contribute to tumorigenesis are currently unclear.
The types of procedures also changed over time with more craniotomies and endovascular procedures being performed.
The typical class of medications used to treat OAB is antimuscarinics.
The typical leftward bias on a line bisection task may reflect cerebral asymmetry.
The typically moderate level of trauma very rarely causes fracture in younger people.
The typical profile of patients with fragile X syndrome changes with age.
The typical psychiatric profile of fragile X syndrome patients includes cognitive and behavioral deficits , psychiatric comorbidity , and autistic characteristics.
The typical structure of polysaccharide was evaluated by IR spectrum.
The typical wrinkled appearance of mature Integra reconstruction cannot be said to be entirely due to a lack of elastic fibers.
The ubiquitin-editing enzyme A20 / TNFAIP3 is essential for controlling signals inducing the activation of nuclear factor-κB transcription factors.
The ubiquitin-proteasome and autophagy-lysosomal systems are the two major proteolytic pathways involved in regulation of both physiological and pathological muscle wasting.
The ubiquitin-proteasome pathway ( UPP ) is the primary cytosolic proteolytic machinery for the selective degradation of various forms of damaged proteins.
The ubiquitin-proteasome system , a major intracellular protein quality control system , has been implicated recently in BACE1 metabolism.
The ubiquitin-proteasome system is the major protein degradation pathway in the cell.
The ubiquitin-proteasome system plays a major role in signal transduction associated with stress and ageing.
The UC group received conventional care alone.
The UDP-N-acetylgalactosamine : polypeptide ( GalNAc-T ) family functions in the first step of mucin-type O-glycan synthesis.
The UFOV® predicted blind-spot errors and errors on dual carriageways.
The UK doctors who trained with Scott soon realized the significant potential offered by BoNT type A as a therapeutic option for several difficult-to-treat diseases.
The UK has an ageing population.
The UK has a rapidly ageing population with increased healthcare needs.
The UK , like other countries , has an increasingly aging Chinese population about who relatively little is known.
The Ukrainian version , however , gave markedly lower probabilities than the Austrian model at all ages.
The ultimate accumulation of brain pathological lesions may be modified by genetic influences , such as the apolipoprotein E ε4 allele and the environment.
The ultimate cause-consequence relationship between these conditions and CNS disorders has not been firmly established and further research is needed.
The ultimate goal of cognitive enhancement as an intervention for age-related cognitive decline is transfer to everyday cognitive functioning.
The ultimate goal of this article is to bring to the attention of clinicians the seriousness of this potentially preventable or modifiable perioperative complication.
The ultimate goal of this process is to expand access to well tolerated and effective lifetime treatment to all those in need.
The ultimate goal of this Prospects is to encourage conduct of well-designed future studies that elucidate the relationship among sarcopenia , SO , and CMD.
The ultimate target is a normalized ocular surface , increased tear stability , and decreased osmolarity of the tear film.
The ultimate treatment decision will rely on an informed conversation between the physician and patient.
The ultimate uncertainty of the method ranged from @number@ to @number@ °C depending on the approach used.
The ultra-long pharmacokinetic and pharmacodynamic properties of IDeg observed in younger adults were preserved in elderly subjects with type @number@ diabetes.
The ultrastructural alterations in human and rat tissue were observed by transmission electron microscopy.
The ultrastructural analysis showed that palatopharyngeal muscle fibers presented cytoplasmic residual corpuscles , a sign of early cell aging.
The ultrastructural examination showed a modified tridimensional architecture of the reticular dermis and the presence of a richer microvascular bed.
The ultrastructure of the cartilage from the two groups was compared with each other.
The unadjusted hazard ratio for those without a high school education in comparison with college graduates was @number@ ( @percent@ CI = @number@.64-3.18 ) .
The unanticipated finding that persons with MetS were faster in processing embedded sentences may represent an impairment of timing functions among older individuals with MetS.
The uncertainty associated with SEE values derived from smaller samples complicates the comparison of approaches based upon different methodology and / or skeletal elements.
The uncoupling of RPE LF content , cell number , and photoreceptor topography in aging challenges LF's role in AMD.
The uncrossed disparity thresholds were also measured with optical blur ( from @number@.0D to @number@.0D added to the best correction ) .
The undeniable progress in the field of biomarker research should lead to a better understanding of the early stages of the disorder.
The underlying aetiology of sarcopenia appears multifaceted and not yet fully defined , but ultimately involves the gradual loss of muscle protein content over time.
The underlying biological mechanisms for MCR have not yet been established.
The underlying cause of this protective role is not fully understood , however , some mechanisms have been proposed in this area.
The underlying causes of these changes are not fully understood but point to alterations in assembly of the machinery for T cell activation.
The underlying factors are generation / cohort effects , cognitive and physical decline related to aging , and negative attitudes toward technologies.
The underlying hypothesis is that the IMT may be an indirect index of vascular damage in persons with low levels of plasma antioxidants.
The underlying hypoxic-ischemic ( HI ) injury triggers an inflammatory response leading to neuronal damage.
The underlying mechanism by which these two peptides can act synergistically was not clear in this study.
The underlying mechanisms are largely unknown.
The underlying mechanisms for these changes are unknown.
The underlying mechanisms how single gene mutations can cause various phenotypes are largely unknown.
The underlying mechanisms influencing arterial elasticity may involve oxidative injury to the vessel wall.
The underlying mechanisms of aging-exacerbated effects remain unknown.
The underlying mechanisms of impaired or preserved cognition are unknown.
The underlying mechanisms of the characteristic neurodegeneration in the substantia nigra ( SN ) are still not fully understood.
The underlying mechanisms of this effect are , however , less clear.
The underlying mechanisms to explain these findings are encapsulated in the term \ "Timing Hypothesis. \ "
The underlying molecular mechanisms are largely unexplored.
The underlying neural mechanisms , however , remain unclear.
The underlying pathology results in a disruption of the individual's ability to tolerate internal and external stressors such as injury or illness.
The underlying pathophysiological mechanism ( s ) explaining why motor memory consolidation in older adults fails to benefit from sleep remains unclear.
The underlying pathophysiological pathways of frailty are not known but the axis and heightened chronic systemic inflammation appear to be major contributors.
The underlying reason might be differences in vascular rather than cardiac autonomic control.
The undermined skin was treated with a fractional laser using different energies depending on the type of skin.
The undermining zone is delimited @number@ cm beyond the medial line.
The understanding of palliative care practices at home ( PCH ) is limited by the lack of available scientific knowledge.
The understanding of the HPA axis and aging remains a complex area with conflicting studies leading to controversial interpretations.
The understanding of the molecular mechanism ( s ) of their regulation in atherosclerosis is crucial for potential therapeutic approaches.
The understanding of this system will enable to define new levers to prevent / treat sarcopenia and osteoporosis at the same time.
The unfavourable generation shifts were mainly found among the lower educated.
The unfolded protein response ( UPR ) operates as central player to maintain ER homeostasis or the induction of cell death of chronically damaged cells.
The unicellular yeast Saccharomyces cerevisiae represents a simple eukaryotic model to study the effects of different compounds on lifespan.
The Unified Biosocial Theory of Personality developed by Cloninger has been applied in different cultures.
The unifying fusion is identified as ' Balancing a changed life situation. '
The unique aspects of elderly patient care require effort and dedication , as well as scientific and appropriate ethical training.
The unique cognitive and psychological features of older adults , however , present a challenge to this agenda.
The unique contribution of children's ability to assess ordinality in numerical symbols steadily increased across grades , overtaking all other predictors by grade @number@
The unique data on inter-ethnic differences will help fill knowledge gaps in stroke epidemiology.
The unique developmental gene expression signature , angiogenesis , and adipogenic potential of SAT determines its growth ability under the positive energy balance.
The unique enzyme Pin1 plays a key role in the pathogenesis of Alzheimer's disease and many human cancers.
The unique features of VASH1 are its anti-angiogenic activity and ability to promote the stress tolerance and survival of ECs.
The unique mechanism of action and high efficacy of PDE5 inhibitors has generated immense interest among researchers dealing with sexual dysfunction.
The unique physiology of the aging cardiovascular system and the impact of these changes during the stress of surgery is presented in this article.
The unique spatiotemporal patterns of neuronal synchrony signify diverse neurophysiological disruptions and pathological underpinnings of the language network in each variant.
The unique , unphysiological Fontan circulation is associated with an impaired functional status of the patients that is suggested to deteriorate over time.
The United States should turn to state rate setting to concentrate purchasing power.
The unit of analysis was person-month ( N = 53 , 971 ) .
The unit of variable was the percentage.
The univariate and multivariate Logistic regression analyses were performed with SPSS @number@
The univariate association of IBS with birth cohort was significant ( p < @number@ ) as was the association adjusted for age and gender.
The univariate log-binominal regression model was used to estimate the prevalence of H. pylori infection , taking birth year into consideration.
The University of Geneva brain collection was founded at the beginning of the 20th century.
The University of South Florida's master's degree in gerontology is a long-established program that focuses on a multidisciplinary approach to population aging.
The unmet needs varied between different health problems.
The unpaired t test ( or Mann-Whitney rank sum test when appropriate ) was used in the statistical analysis.
The UN population figures for Africa for @number@ @number@ and @number@ were used to estimate the cases of asthma , each for the respective year.
The unsuitable conditions may delay wound healing process and cause chronic wound or scar formation.
The untreated side served as control.
The Unusual Box test is a nonverbal and nonimitative test in which children play individually with a novel toy and novel objects.
The uPAR deficiency attenuated differentiation media-induced adipocyte differentiation.
The updated results indicate that the gradual increase would have continued through @number@ after which driver fatality rates again would have declined through @number@
The UPM was initially developed to study rate acceleration / deceleration in sequence evolution.
The upper extremity was modeled as a @number@ degrees-of-freedom system.
The upper facial profile was displaced in the anterior direction and the whole profile was displaced inferiorly for both sexes.
The upper limits of the @percent@ confidence intervals were less than the prespecified noninferiority margin ( @number@ h ) .
The upper / lower lip ratios for area and volume were similar in the two genders.
The upper lumbar spine is more flexible in individuals in their twenties compared to those in their sixties.
The upper meibomian gland area ( uMGA ) was calculated and set in relation to the total tarsal area of the lid.
The upper zone of the lungs was almost always involved.
The UPR also activates the nuclear factor @number@ ( Nrf2 ) , a central transcriptional factor for cytoprotection against stress.
The UPR constitutes a series of adaptive programs that preserve ER protein-folding environment and maintain hepatic lipid homeostasis.
The up-regulation of miR-31 was accompanied by repression of the polycomb group ( PcG ) protein BMI1 and induction of cellular senescence.
The UPR has three arms , which regulate protein synthesis and expression of many ER chaperone and regulatory proteins.
The UPRmt may increase life span by stimulating mitochondrial turnover through autophagy , and / or by inhibiting the production of hormones and toxic metabolites.
The UPR restores ER homeostasis by degrading misfolded proteins , inhibiting translation , and increasing expression of chaperones that enhance ER protein folding capacity.
The UPSA-B identified HIV + persons with cognitive impairment with @percent@ accuracy.
The upshot may be a pro-atherogenic state.
The upshot of these arguments is that the population problems discussed provide scant reason to oppose life extension by slowed ageing.
The uptake and metabolism of iodide by thyrocytes is crucial to proper thyroid function.
The upward trajectory of age-stereotype negativity makes a case for remedial action on a societal level.
The urinary BPA concentration increased after consuming canned beverages by > 1600% compared with that after consuming glass bottled beverages.
The urinary β ( @number@ ) -microglobulin-creatinine ratio ( UBCR ) was assessed in morning spot urine samples.
The urologist should be aware of the potential complications and perform regular follow-up.
The urothelium is a newly recognized sensory structure that detects bladder fullness.
The usability of the system was verified using a technology acceptance model-based study of @number@ elderly people.
The usage of JAK2 signal inhibitor , CP-690550 , enhanced Adriamycin-induced cell aging.
The usage of uncalibrated assays hinders the comparability of SELENOP concentrations and their pathophysiological interpretation across different clinical studies.
The US Census Bureau expects the population aged ≥65 years to more than double by @number@
The use and costs of drugs were based on data from the Danish Medicines Agency.
The use and type of medication in Alzheimer's disease ( AD ) patients and association with falls is limited.
The Useful Field of View Test ( UFOV ) is often used as a behavioral assessment of age-related decline in visual perception and cognition.
The usefulness of a recently revised version of the shortened MNA ( MNA-SF ) was also investigated.
The usefulness of diffusion-weighted magnetic resonance imaging ( DWI ) in the evaluation of scrotal pathology has recently been reported.
The usefulness of GA is also shown in hematological malignancy.
The usefulness of the final set of criteria was assessed with regard to the prescription of antipsychotics for delirium and BPSD.
The usefulness of their combined evaluation has never been tested.
The useful properties are exploited by enzymatic catalysis.
The use of age- and sex-specific FMD data may therefore not be pertinent in childhood and adolescence.
The use of age-based normative values when considering an elderly population improves the risk discrimination of diastolic measures for incident HF or death.
The use of agents with a good safety profiles and with the least possibility of causing hypoglycemia is warranted.
The use of a less aggressive regimen could be attributed to the higher prevalence of complications and problems.
The use of alternative tilting during WBV to ameliorate bone mass and bone metabolism , particularly in senior people , has not previously been reported.
The use of animal models of AD has initiated the deciphering of these molecular pathways and mechanisms.
The use of antibiotic prophylaxis to reduce neutropenia-related infectious complications in patients with cancer is still object to debate.
The use of anticholinergic medicines is associated with the risk of morbidity , mortality and cognitive decline , particularly in older people.
The use of antidepressants was low in men and women and was related mainly to disability in ADL.
The use of antimicrobial agents has increased in recent years as treatments have diversified and resistant bacteria have appeared.
The use of antioxidants and polyphenols may exert an anti-aging effect by preventing and even reversing sun damage.
The use of antiplatelet therapy ( APT ) and / or anticoagulant therapy ( ACT ) continues to increase due to the aging population.
The use of any anti-dementia drug or combination was associated with the mood and apathy subgroup.
The use of a short form of the MSRA questionnaire improves the capacity to identify sarcopenic subjects.
The use of assistive devices was positively related , but the use of personal help was negatively related to well-being.
The use of attentional deployment tactics was associated with lower negative affect.
The use of a vitamin D supplement ( @number@ μg per day ) recommended.
The use of bioresorbable scaffolds is speculated to be one factor affecting these valves ' failure.
The use of bipolar plasma vaporization is not well studied in an office setting.
The use of both SBs and LBs by old persons should be strongly discouraged.
The use of capillary viscometer to evaluate salivary aging needs more improvements.
The use of collagen hydrolysates ( CHs ) as a nutraceutical agent in skin aging has gained increasing attention.
The use of complementary or other therapies and the number of days the therapies were used varied for specific symptoms.
The use of complex cooperative strategies to minimize risk is a necessary precursor for selecting further reductions in mortality rate in late adulthood.
The use of complex syntax in the spoken discourse of young , middle-aged , and older adults was examined.
The use of computerized testing as a means for cognitive screening and brief cognitive testing is increasing at a rapid rate.
The use of CSDD did not include a clinician׳s interview with the patient.
The use of ctDNA might help to determine the disease prognosis , monitor disease progression , monitor the molecular resistance and monitor the tumor heterogeneity.
The use of DAPs was estimated using definitions from the previous scientific literature.
The use of death certificates for studying dementia grossly underestimates the occurrence of dementia in the population.
The use of decision limits for lipids and glycated hemoglobin.
The use of dietary intervention has evolved into a promising approach to prevent the onset and progression of brain diseases.
The use of digital photography will make it easier and more convenient.
The use of diuretics , calcium channel blockers , angiotensin-converting enzyme inhibitors , or vasodilators alone was not significantly associated with cognitive impairment.
The use of diuretics was associated with a lower clearance.
The use of DNA methylation ( DNAm ) to obtain additional information in forensic investigations showed to be a promising and increasing field of interest.
The use of dual-task training paradigm to enhance postural stability in patients with balance impairments is an emerging area of interest.
The use of effective strategies during encoding correlated with memory performance and FOKs , even for unrecalled pairs.
The use of exogenous DNA repair enzymes presents a novel way to supplement intrinsic mechanisms and improve their efficacy.
The use of fractional lasers in stretch marks , melasma and other pigmentary conditions , dermatological conditions such as granuloma annulare has been reported.
The use of GCS provided better discrimination and was chosen for further examination.
The use of growth hormone-releasing factor as a viable treatment option for increased visceral abdominal tissue has recently been confirmed for selected patients.
The use of health-economic data is different between Japan and UK.
The use of high-throughput technology allows us to obtain visual and quantitative data on a large number of samples quickly and easily.
The use of images of older people in the British advertising media has been under-researched to date.
The use of implanted pacemaker devices is increasing worldwide , owing to technological advances , new indications , and an aging population.
The use of individual subscales also warrants further investigation.
The use of iPSs , however tantalizing , poses serious safety concerns because of their genomic instability.
The use of isoperformance curves is presented as a method for this determination.
The use of kinematics is recommended to quantitatively evaluate upper limb movements.
The use of laparoscopy was associated with improved SSI.
The use of large-particle stabilized hyaluronic acid-based gel of nonanimal origin ( NASHA™ ) for facial aesthetic procedures is widespread and increasing.
The use of long-term care ( LTC ) is changing rapidly.
The use of medications for the treatment of general symptoms ( e.g. , analgesics ) will also rise.
The use of modern osteosynthesis procedures can provide an improved , individualized surgical treatment with early full weight bearing of the affected extremity.
The use of multiple drug treatment did not predict a better control.
The use of narrow spectrum antibiotics could be helpful to some extent.
The use of neuroleptic drugs was also a prominent individual risk factor , although the prevalence was low.
The use of neuromodulators for therapeutic and cosmetic indications has proven to be remarkably safe.
The use of new-generation DES reduced the risk of MI in the elderly population.
The use of NSAIDs was not associated with paroxysmal AF.
The use of old drugs for new indications is promising , as are traditional herbal medicines.
The use of opioids or psychotropic medicines was associated with PIM initiation in both cohorts.
The use of OTC medicine has been reported as common amongst elderly patients.
The use of our cosmetic toolbox can differ for men in terms of technique and dosage.
The use of percutaneous cemented screws is , in our experience , a valuable alternative for spinal fixation in patients with poor bone stock.
The use of phosphodiesterase-5 inhibitors increased from @percent@ to @percent@ from baseline to year @number@ on active surveillance.
The use of physical exercises might strengthen the habit to training.
The use of physical restraints coincides with stress , further aggravating the already existing neuropathology , which may increase stress and agitation even more.
The use of PIMs was measured based on @number@ Beers criteria , @number@ AGS Beers criteria and the EU ( @number@ ) -PIM list.
The use of PLGA / HA with a rubber dam significantly improved the periodontal parameters in both smoking and non-smoking subjects.
The use of polypharmacy may also cause itch , with or without a rash.
The use of psychotropic drugs for older individuals with ID and behavioral problems remains controversial , particularly in those with dementia.
The use of PWV as an index of arterial stiffening may thus lose its validity if tethering is involved.
The use of rescreening after a negative screening colonoscopy above @number@ years of age may be very limited.
The use of rodent model to understand immunosenescence may help the development of treatments to improve the immune fitness of the aged.
The use of salivary T ( sal-T ) , as a determinant of systemic T , has shown promising results in recent years.
The use of seven technologies important for e-health services was specifically examined for each subsample and compared between the subsamples.
The use of statin drugs was significantly associated with lower odds of SPN , and it may prevent progression from no SPN to SPN.
The use of such predictions in large populations could be of interest for many public health issues.
The use of sunscreens has led to reduced amounts of radicals compared to untreated skin.
The use of supramaximal single stimulation and the analysis of time and slope parameters may not be recommended for estimating changes in muscle mass.
The use of the AGE-crosslink breaker Alagebrium had no independent effect on vascular function , nor did it potentiate the effect of exercise training.
The use of the antioxidant N-acetyl cysteine prevented the induction of HO-1 by curcumin.
The use of the Clock Drawing Test is an easy to administer measure of EF that can be used routinely in comprehensive fall risk evaluations.
The use of the IADL scale in men may not be as reliable as in women.
The use of the orbicularis oculi muscle suspension flap is a useful adjunct to the transcutaneous approach to lower lid blepharoplasty.
The use of the results of the investigation optimizes the detection of patients with impaired hemoglobin formation.
The use of this device in upper arm loose skin has not been investigated.
The use of this maker modestly improves AF prediction.
The use of this technology also spans across several contexts including cognitive , physical , and leisure ; all of which support multidimensional well-being.
The use of this type of battery can overcome many of the logistic constraints associated with current functional assessment protocols.
The use of threshold values indexed to age should be encouraged to better prevent and eventually treat TBAD.
The use of Traditional Chinese Medicine to treat AD has been increasing in recent years.
The use of traditional methods of cleansing with soap and water in the management of skin integrity consumes significant amounts of nursing time.
The use of vincristine , a known antitumor agent , in hepatoma therapy is limited particularly because of its toxic effect.
The use of warmed blankets may increase patient comfort.
The use , whenever possible , of common reference values.
The U-shaped curve of the mortality hazard by BMI is wide.
The US Military HIV Natural History Study ( NHS ) cohort provides a different validation population profile , being younger and healthier.
The usual care phase included collection of the D2S2 information , but not sharing the information with case managers.
The usual dental diseases , caries and periodontal pathology ( @number@ and @percent@ , respectively ) , were common in the third molars.
The usual dose of @number@ g / day may be routinely recommended to maintain or improve muscle mass and function in health and disease.
The usual health care safety nets expected in western countries do not cover their nationals in a foreign country.
The usual loss of mobility with age , however , reflects both a decrease in capacity and a lowering of the threshold for reporting difficulty.
The U.S. United Network for Organ Sharing ( UNOS ) thoracic and liver databases were queried for cardiac and CHD diagnoses , from inception-2014.
The U.S.-wide prevalence of venous thromboembolism ( VTE ) is unclear , with reported VTE incidence estimates varying widely.
The utility of baPWV as a diagnostic , prognostic , and therapeutic indicator for hypertension warrants further investigation.
The utility of completion of advance care planning and designation of a judicially appointed guardian is frequently endorsed by the sample.
The utility of Erikson's model is suggested as a means of enhancing self-awareness , self-understanding , and adjustment to retirement.
The utility of information processing speed ( IPS ) enclosed with multiscale constructs in the diagnosis of NCD warrants exploration.
The utility of postmortem microbiology has continuously been a topic of controversy.
The utility of pressure rate constants derived from reservoir-wave analysis in prediction of cardiovascular events is unknown.
The utility of these nontraditional risk factors will also need to be proven in sufficiently large and properly designed interventional studies.
The utility of this scale in other patient populations will require further study.
The utilization of multi-spectrum networks in identifying MCI individuals is motivated by the inherent frequency-specific properties of BOLD spectrum.
The utilization of radiofrequency technology remains a novel method for the treatment of many aesthetic and medical dermatological indications.
The UVA / UVB ratio can vary with latitude , season , hour , meteorology and ozone layer , leading to different exposure conditions.
The UV-Vis spectra of the glycated gelatines confirmed the presence of AGE fluorophores.
The vaccine with the highest rates of adverse events is the tetanus booster , with local pain and swelling at the injection site.
The VACS Index score did not significantly change with transitions in frailty status over time.
The vagina was circular at the introitus and gradually flattened between bladder and rectum.
The VA integrated model of HIV care may discourage outside use among HIV-infected veterans.
The valent color was associated with either a positive or negative payoff , whereas the neutral color was not associated with a payoff.
The validation of FORTA's impact on clinical endpoints has yielded promising preliminary results , to be corroborated in ongoing larger trials.
The validation results imply that the established method could be used as a clinical diagnostic for RA together with RF-IgM.
The validation sample consisted of @number@ @number@ participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.
The validation standard was diagnosis of dementia and MCI based on in-person evaluation.
The validity and predictability of documenting this effect is targeted within planned future research efforts.
The validity and reliability of EQ-5D were tested.
The validity and reliability of questionnaire confirmed by experts and Cranach's Alpha coefficient ( @percent@ ) .
The validity of diagnostic indices for speech obtained from speech-like or nonspeech tasks must thus be called into question.
The validity of the articles was given by the degree of evidence demonstrated by describing the recommendations and the applicability to our context.
The validity of the phenotype may be enhanced through the use of longitudinal trajectories.
The validity of using self-reported methods to quantify dietary intake has not been evaluated in childhood cancer survivors.
The valuation of food is a fundamental component of our decision-making.
The value of AMH in the diagnosis of PCOS remains controversial , but it may replace AFC in the future.
The value of a team approach in addressing occupational health problems was demonstrated.
The value of GA in predicting toxicity and mortality in older patients with cancer undergoing treatment with chemotherapy has not been proven.
The value of increased triglyceride was independently associated with higher waist-hip ratio , higher body mass index and smoking.
The value of informal care peaked at €13 , 590 / yr.
The value of real time three-dimensional real time echocardiography in the assessment and management of aortic stenosis in older adults is emphasized.
The value of Spearman's rank correlation coefficient calculated for the correlation between the child's age at death and the neonatal line width was statistically significant.
The value of testosterone replacement therapy ( TRT ) for older men is currently a topic of intense debate.
The value of the standard error of quantification was not different from previous reports for other population groups.
The values derived were compared with threshold values , which differentiate between osteoporotic and nonosteoporotic states ; age-stratified groups were also compared.
The values for the depression item of the UPDRS were slightly lower.
The values obtained for internal consistency for the total scale and for each subscale were good ( α > @number@ ) .
The values obtained for keratometry , corneal astigmatism , and corneal irregularity were studied.
The values of arterial blood pressure according to the Yakutsk population screening at the age of @number@ and older have been studied.
The values of coherence during motor planning , instead , correlated with movement time , peak velocity and acceleration.
The values of fold change of Cr , Fe , Mn , and Co were @number@ @number@ @number@ and @number@ respectively.
The values of odds ratios were found to decrease from the 60-61 to 68-69 years age groups.
The values of SEn decreased almost linearly from the DOWN to the UP conditions , with significant interaction effects of age for anterior-posterior SEn.
The valves were tested in a heart flow simulator , and were studied using echocardiography.
The variability and predictors of urinary concentrations of phthalate metabolites in preschool-aged children have not been thoroughly examined.
The variability of force is indicative of the biological variability inherent in the human motor system.
The variability of the FM estimates was large and these indexes cannot be recommended for the assessment of FM in older subjects.
The variability potential of a phenotype , on the background of the same genotype , is termed \ "phenotypic plasticity \ ".
The variable dilution ratios , reconstitution times , injection techniques and rates of nodule formation with poly-L-lactic acid can be intimidating to even experienced injectors.
The variable includes all the values of systolic blood pressure , heart rate and age , without limiting values for any of these.
The variable \ "Jung \ " was used : ( systolic bloog pressure / heart rate x age ) @date@ .
The variable phenotypes among these GSS patients indicated other genetic or environmental factors might be involved in the phenotypic heterogeneity of GSS.
The variables associated with an increased likelihood of being in the FR group were age , female , and living with families.
The variables associated with outcomes were analyzed in univariate and multivariate logistic regression.
The variables associated with this deficiency provide insight into the next steps needed to characterize older adults with this deficiency and to treat it accordingly.
The variables gender and evaluation sites were checked.
The variables most affected by ε4 were the Delirium Index and Mini-Mental State Examination.
The variables of age , medications and physical activity were significant for predicting the Berg score.
The variables were classified according to the \ "behavioral model \ " in predisposing , enabling or need variables.
The variables were compared using chi-square.
The variables with significance ( P < @number@ ) were then analyzed with Logistic regression model.
The variable visiting / visits from friends was associated with reduced risk of all-cause dementia.
The variance explained in the SOC , PA , and falls risks were @percent@ , @percent@ , and @percent@ , respectively.
The variant alleles of these SNPs were associated with longer telomere length.
The variant also was related to longevity in the Icelandic population.
The variant at SEC31B is significantly associated with SEC31B expression in heart and tibial nerve tissue.
The variant calling was based on the GATK best practice workflow and annotated using Annovar tool.
The variant is associated with expression of CADM2 in the cingulate cortex ( P-value = 4 × 10 ( @number@ ) ) .
The variants result in the amino-acid exchanges p. ( Lys434Asn ) and p. ( Gly436Arg ) .
The variation in cell size and percentage of regular hexagonal cells are not dependent on age.
The variation in information needs indicates that future decision support tools should provide options to select what information would be of interest to the participants.
The variation in normal observers ' color perception and discrimination will occur with the aging effect.
The variation in outcomes that persist may be partially explained by pretreatment ovarian reserve.
The variation in rates attributable to the hospital after adjusting for case-mix and state was @percent@.
The variation in stiffness among the pelvic floor organs could be shown.
The variation in the accrual of these age-related vascular changes is a function of multiple genetic and environmental factors.
The variation of curvature and of external but not internal residual stretch resembled that of opening angle.
The variations constitute two main haplotypes ( GT , AC ) .
The variation with time of the peak areas of these compounds was used to construct different statistical models that could predict the gunpowders age.
The variety of information imparted by a single neuron then greatly increases the sophistication and complexity of local control mechanisms.
The variety of the tasks and contexts they are used in require a deep understanding of the AHRS accuracy for optimal data interpretation.
The various anatomical structures important for the understanding of the symptoms and the proposed treatment are described in this article.
The various concentrations of CAE , CAH , chlororgenic acid and caffeic acid were subject to MMPs and elastase inhibition tests.
The various drivers to encourage adoption of evidence-based fall risk management strategies will be described.
The various explanatory models explained between @number@ and @percent@ of the variance in outcomes.
The various grades of commercial DSM solutions were suspected to be the origin of the discrepancies.
The various operational definitions of frailty can at least partly explain such discrepancies.
The various steps needed for the development of such interventions are described along general lines.
The various trend lines point to @number@ at the age of @number@ years , which is in line with the present human survival age.
The various types of DRPs identified by all of the three prescribing criteria were represented by @number@ different terms.
The vascular changes were associated with major histocompatibility complex class II + cellular staining throughout the retina.
The vascular insults by hypertension , hyperglycemia and aging may share the changes with diabetic vascular beds.
The vasculature possesses essential anticoagulant factors that regulate coagulation.
The vasodilator prostacyclin tended ( P = @number@ ) to be higher in plasma with training in the postmenopausal women only.
The vasodilatory response to passive leg movement ( PLM ) appears to provide a novel , noninvasive assessment of vascular function.
The vasohibin ( VASH ) family consists of two genes , VASH1 and VASH2.
The vast majority ( n = @number@ @percent@ ) reported having at least one resident with an antipsychotic prescription in their home.
The vast majority of the study group included individuals at the secondary education level , as well as married individuals.
The vast majority of those failing either or both tests had blue-yellow defects , in agreement with previous studies.
The vast majority were MSM with an average age of @number@ years.
The vBMD in the middle of the mandible was the highest , followed by that in the body and at the angle of mandible.
The VCE completion rate and clinically significant findings were studied.
The vector of tissue displacement is upward and concentric , opposing the vector of the aging process , and the fixation is consistent.
The vectors were transfected into porcine fibroblasts then CA-Klotho and Tet-Klotho cell lines were established.
The VEGF protein fuel vessel growth ( angiogenesis ) and therefore enhances the nutrients available to surrounding cells.
The VEGF Trap inhibited the formation of NV , but higher doses also inhibited revascularization of retina when injected at P8.
The Venalink® , Nomad Clear® and Dosett® MMDs were tested.
The ventral and dorsal heights of intervertebral disc were significantly higher than those before operation ( P < @number@ ) .
The vertebrae and discs also had abnormalities in size , shape and structure.
The vertebrae were CT scanned to develop computational models and mechanically tested in compression to measure failure load , stiffness and to observe crack location.
The vertebral angle and distance data were analyzed for a male subgroup approximating the height and weight of a 50th percentile male dummy.
The vertebral angles also varied with age.
The vertebral bodies had increased thickness of hyaline cartilage which enveloped ossification centers.
The vertebrate lens evolved to collect light and focus it onto the retina.
The vertebrate retina is a well-characterized model for studying neurogenesis.
The vertebra-to-front skin distance also differed depending on vertebral level.
The vertex-by-vertex cross-algorithm comparison was made possible applying the 3D gradient vector flow ( GVF ) and closest point search ( CPS ) techniques.
The vertical grab bar and wall touch resulted in the safest ( best controlled ) transfers.
The vertical platform acceleration ( peak values of maximal displacement from equilibrium ) was quantified during each vibration exercise using an accelerometer.
The vertical position of the center of mass ( COM ) was also measured to assess the change in vertical postural control.
The very high prevalence of hypertensive nephrosclerosis in populations from African ancestry has suggested a genetic predisposition.
The very same mutation was reported as cause of HMSN-P during the course of the study.
The vessel wall is considered to have finite thickness with or without tethering and with a range of mechanical properties ranging from viscoelastic to stiff.
The Veterans Aging Cohort Study ( VACS ) Index has previously been used to identify frail HIV-infected persons.
The VHA's randomized rollout of VD-HCBS to veterans at risk of nursing home placement is an example of how to achieve these goals simultaneously.
The VIA accounted for significantly more variance in language ability than the BCCV , above and beyond acculturation proxies.
The viability of SH-SY5Y cells exposed to 4μg oxLDL and 25µM 27-hydroxycholesterol ( 27OH-C ) was decreased significantly.
The victim's personal and family medical histories were negative for cardiac events.
The Vietnam Era Twin Study of Aging ( VETSA ) is a longitudinal behavioral genetic study focused on cognitive and brain aging.
The viewing window task more naturally replicates scenarios in which haptic and visual information would be combined to achieve a higher-level goal.
The view of the human urinary bladder glands in the macro-microscopy investigation is different.
The views of the older person must be considered and respected.
The view that Alzheimer's disease ( AD ) is a fatal outcome of ageing prevails over the view that it mainly affects people aged 75-95.
The VIP had very low sensitivity ( ≤26% ) and high specificity ( ≥80% ) .
The viral load remained low , without correlation with the activation.
The viral transactivator in turn induced CCRK expression through enhanced AR signalling , thus forming a positive regulatory loop.
The Virtual Cohort was merged with the @number@ Veterans Large Health Survey to adjust for self-reported smoking in a nested sample ( @percent@ ) .
The visceral fat area increased by @percent@ in men and by @percent@ in women.
The viscosity of the formulations at @number@ °C ranged from @number@ @number@ to @number@ @number@ cP.
The visit group included @number@ individuals in the visit group and @number@ people in the control group.
The VISIT group received the same intervention at home.
The visual acuity and cognitive measures had different age trajectories , and the visual acuity-cognition relations were similar in each 5-year age band.
The visual area of the left hemisphere becomes \ "the leading \ " analyzer.
The visual processing of complex motion is impaired in Alzheimer's disease ( AD ) .
The visual tracking task involved three different rates of force production ( @number@ @number@ and @percent@ maximal force / s ) .
The vitamin D insufficiency only group was not significantly associated with functional limitations nor ADL disability.
The vitamin D levels decreased from baseline to the second and third measurements.
The vitamin D serum levels and receptor sub-genotypes are also compared , and there was no significant difference between the groups.
The vitamin E and vitamin C treatment ended in @number@ and observational follow-up continued through @date@ .
The vitamin E-verbal memory association was partially mediated by depressive symptoms ( proportion mediated = 13%-16% ) .
The vitreous becomes liquefied and there is a loss of vitreous compartmentalization.
The vitreous cortex was extremely thin at the central fovea , and it gradually thickened along with age in the perifoveal area.
The vitreous is a complex structure whose composition and appearance change with age.
The VLBW neonates demonstrated an elevated SBP as early as @number@ year of age.
The V-LH carrier status did not affect sperm parameters and other circulating reproductive hormones.
The VNA results mimicked the HI profiles , but the profiles for B-cell ELISPOT did not.
The void volume was smaller than the volume corresponding to the typically recommended amount of sunscreen application except for the cases of largest roughness.
The voltage-dependent anion channel ( VDAC ) is a pore located at the outer membrane of the mitochondrion.
The volume and dimensions of the substantia nigra were similar in Parkinson's disease and controls , but reduced in progressive supranuclear palsy.
The volume displacement of the rib cage is related to changes in its circumference using an empirical equation presented by Agostoni et al.
The volume of distribution increased by @percent@ during ECMO support.
The volume of sedentary behaviour increased with age , whereas ambulatory activity reduced with age.
The volume of the larynx and hypopharynx was significantly affected by height and age.
The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction.
The volume of WMH was also automatically measured.
The volume requirements for optimal growth and development of the ventricle and the lungs are different and divergent.
The volumes of the cores decreased and their shapes changed from near spherical to spheroidal.
The volumes , T1WI , T2WI SIs and ADCs of three major salivary glands were measured.
The volumetric techniques of injectable fillers and autologous fat transfer are an important tool in the treatment of facial aging.
The volunteers ' sharing of knowledge , experience , and support with each other were also noticeable in their accounts of their service.
The volunteers were allocated to two groups of @number@ individuals each , i.e. , isoflavone and placebo.
The volunteers were examined at baseline , after @number@ months , and @number@ weeks after termination of treatment ( month @number@ ) .
The von Economo neurons ( VENs ) are large bipolar Layer V projection neurons found chiefly in the anterior cingulate and frontoinsular cortices.
The V ( O₂p ) was measured breath by breath using mass spectrometry and a volume turbine.
The VR was similar across all age groups.
The VSM test estimated how many locations each subject could memorize.
The VTE was used to morph the standardized parcellation map of the JHU-neonate-SS atlas to capture the anatomical features of a study population.
The VT values were @percent@ higher in HAB than in MAB , although the difference was not statistically significant.
The vulnerability of adolescents is often attributed to risky sexual behaviors , whereas biological factors affecting mucosal immunity are poorly understood.
The WAI did not differ between groups ( p = 0.237 ) .
The WAIS-III Information subtest is proposed here to measure this influence at old age.
The waist / height ratio and bone mineral content were not associated with adiponectin in either gender.
The WAI was moderately correlated with the sit-to-stand test among older female workers ( r = 0.573 , p = 0.051 ) .
The walking and stair-climbing items were formed into two super-items to remove response dependency.
The walking group remained stable in the cognitive performance of most of the tests , except attention.
The walkway assessed the risk of falling associated gait parameters velocity , swing time , stride length , stride time- and double support time variability.
The wall-to-lumen ratio measured by AO can be used to detect structural retinal microvascular alterations in an early stage of remodeling processes.
The warning effect in younger participants was not specific to impending perturbation conditions.
The warning was combined with integration instructions in Experiment @number@
The water bolus was held in their mouth until they were forced to do a rapid swallow.
The water-surface contact angle was assessed before and after chemical modification of the dentin matrix.
The way acuity and straylight are measured ensures no confounding between them.
The ways in which genes that regulate epigenetic mechanisms might modulate senescence / immortalisation and how these pathways could influence cancer development are explored.
The way stress influences physical health is gaining increasing support.
The WBV group performed exercises on a vibration platform 3× / week.
The WBVT groups trained for @number@ weeks on a vibration platform , while the control groups performed identical exercises , with no vibration.
The wearing of protective clothing and the use of sunscreens are important preventive measures.
The wear on antagonist steatite balls was also measured after mastication simulation.
The wear rate was with @number@ ± @number@ mg / million cycles falling within the limit of previous reports for established wear test methods.
The website development followed the steps : analysis and planning , modeling , implementation and evaluation.
The website's content was classified as \ "adequate \ " and the website's technical quality as \ "excellent \ ".
The weekly frequency of LW , in turn , was associated with all QOL domains.
The weekly volumes of MVPA and LW were associated with several domains of QOL.
The weight coefficients for the @number@ dimensions were @number@ @number@ @number@ and @number@ respectively.
The weighted Gini coefficient for closures was @number@ across all metropolitan statistical areas and @number@ across zip codes.
The weighted Gini coefficient was used to measure geographic concentration of closures , and geographic information system maps to illustrate spatial clustering patterns of closures.
The weighted prevalence of participants with consumption of alcohol in the Chinese sample of women and men were @percent@ and @percent@ , respectively.
The weight loss groups experienced a @percent@ lower all-cause mortality risk ( RR = @number@ @percent@ CI : @number@.73-1.00 ) .
The well-vascularized deep-plane flap minimizes complications.
The WEL was administered prior to randomization and again at the 6-month follow-up visit.
The Werner syndrome protein ( WRN ) is a member of the human RecQ family DNA helicases implicated in the maintenance of genome stability.
The Werner syndrome protein ( WRN ) suppresses the loss of telomeres replicated by lagging-strand synthesis by a yet to be defined mechanism.
The Western blotting analysis presents that CASP9 expression associated with inhibition of miR-182.
The Wheelchair Self-Efficacy Enhanced for Use ( WheelSeeU ) research program provides peer-led training that may positively influence wheelchair use while reducing clinician burden.
The WHI raised many important questions.
The WHI results were initially reported for all subjects , and showed little difference when data were not analyzed by age.
The WHI started HT treatment on women aged 50-79 years in order to ascertain these effects.
The white color of canities is an optical effect ; the reflection of incident light masks the intrinsic pale yellow color of hair keratin.
The WHO cut-off point offered very low sensitivity ( @percent@ ) .
The WHO cut-off value ( T-score ≤-2.5 ) was used for the definition of osteoporosis.
The whole brain network was characterized with graph theoretical metrics and decomposed into modules.
The whole cohort of people @number@ years or over irrespective of health status or dwelling place in a geographical area was invited to participate.
The whole procedure was repeated on a second occasion.
The whole process was developed according to the PRISMA statement.
The whole profile was displaced in the inferior direction.
The whole-spine sagittal balance can deteriorate if the compensatory changes in the lumbosacral spine are insufficient.
The whole study group was stratified by age ( < / = 60 and 60 + yrs ) and by the reason for MR prescription.
The WHOQOL-BREF and WHOQOL-OLD instruments were used to measure QOL , while the weekly volume and frequency of MVPA and LW were assessed by IPAQ.
The WHOQOL-BREF measured quality of life and health satisfaction.
The WHOQOL-BREF revealed that the general domain played a major role compared to other domains.
The WHOQOL correlated positively and strongly with the single-item measure.
The WHOQOL-OLD showed satisfactory reliability with Cronbach's Alpha coefficients ranging from @number@ ( Social participation ) to @number@ ( Sensory ability ) for each domain.
The WHO recommends exclusive breastfeeding during the first @number@ mo of life ; however , deviations from this recommendation are widespread.
The widely accepted oxidative stress theory of aging postulates that aging results from accumulation of oxidative damage.
The widely held view that they enhance catalysis by channeling substrates is challenged by both structural and biophysical information.
The widely observed between-subject variability in cognitive responses to coffee may have a genetic basis.
The widening gap between transplant demand and supply has prompted the expansion of selection criteria for kidney donation to increase the available donor pool.
The wide spectrum of neurodegenerative disorders associated with olfactory dysfunction suggests different , potentially overlapping , underlying pathophysiologies.
The widespread roll-out of antiretroviral therapy ( ART ) has substantially changed the face of human immunodeficiency virus ( HIV ) .
The Wiedemann-Rautenstrauch syndrome ( WRS , OMIM : @number@ ) characterizes a premature aging syndrome in which several features of aging are apparent at birth.
The WIG1-AGO2 complex attenuated translation initiation via an interaction with translation initiation factor 5B ( eIF5B ) .
The willingness of all involved to support a completely independent process underlines a commitment to trust the evidence.
The wines were sealed with six types of bottle stoppers.
The WIQ should probably be used with caution in clinical routine , and constant-load treadmill testing is probably not the ideal candidate in elderly patients.
The within-subjects paradigm includes four controlled conditions.
The WM training consisted of five tasks that were trained in each of @number@ sessions.
The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral fracture risk in humans.
The Wnt inhibitors dickkopf-1 ( DKK-1 ) and sclerostin negatively impact bone formation and are considered targets for the treatment of bone disorders.
The Wnt / β-catenin signaling pathway plays an essential role in osteoblast biology.
The women completed a health and lifestyle questionnaire.
The women completed an in-depth qualitative interview on the psychosocial impact of breast cancer and the meaning and nature of social support.
The women in this study appeared to underreport the level of difficulties they experienced.
The women navigated beyond the triple barriers to life after cancer.
The Women's EMPOWER Survey : Identifying Women's Perceptions on Vulvar and Vaginal Atrophy and Its Treatment.
The Women's EMPOWER Survey : Women's Knowledge and Awareness of Treatment Options for Vulvar and Vaginal Atrophy Remains Inadequate.
The Women's Health Initiative offers the unprecedented opportunity to systematically address both of these issues.
The Women's Health Initiative ( WHI ) assessed the long-term effects of hormone therapy ( HT ) in postmenopausal women.
The Women's Health Study was registered at clinicaltrials.gov as NCT00000479.
The Women's Healthy Aging Project ( WHAP ) is a longitudinal study of over @number@ Australian-born women , epidemiologically randomly sampled in @number@
The women were studied before and during autonomic blockade using trimethaphan camsylate.
The Word Accentuation Test ( WAT ) was used as measure of oral reading ability.
The word recognition thresholds for older adults , however , did not appear to change over the range of delays explored in this study.
The words ' ambulance ' and ' paramedic ' may hold different latent connotations for different callers.
The work and educational opportunities domain was excluded from analysis , because it was only applicable to @number@ persons.
The work deficit scores showed that those removed for behavioural issues had a greater impact on the overall workforce than those removed for health reasons.
The workers filled out questionnaires on demographics , work , sleep , and health.
The workers that were interviewed for this study show a reduction in their functional ability to work starting at @number@ years of age.
The working group organised a workshop to present useful datasets on ageing in Germany for epidemiological research.
The working recommendations are presented in lists of features , and suggested assessment tasks are also provided.
The working time for all three groups was fixed at @number@ min.
The work is of high clinical importance given the rapidly growing ageing population and the accompanying costs to health systems globally.
The work of Herbert Spencer about the origins and function of music heavily influenced Jackson and others in their thinking about aphasia.
The workplace could serve as arena for preventive interventions regarding disability in old age.
The work presents the research data on quality of life of @number@ patients with temporary intestinal stoma.
The work was carried out in @number@ Latin American and Caribbean ( LAC ) cities in 1999-2000.
The world elderly population is rapidly increasing.
The world faces an aging population that implies a large number of people affected with chronic diseases.
The World Health Organization's age-friendly community framework contextualized the study findings.
The World Health Organization ( WHO ) estimates that @number@ billion people will be overweight and @number@ million obese in @number@
The World Health Organization ( WHO ) has formulated guidelines for a healthy diet to prevent chronic diseases and postpone death worldwide.
The World Health Organization ( WHO ) oral health assessment form was used for examining the study participants.
The World Health Organization ( WHO ) 's Age-Friendly Community ( AFC ) initiative has gained worldwide momentum.
The World Health Organization ( WHO ) set a goal of @percent@ influenza vaccination coverage among the elderly by @number@ but it was not achieved.
The world population is continuously aging , and centenarians may be considered to be the most successfully aged individuals.
The world population is growing older and age-related cognitive decline is becoming a burden of societal importance.
The world's population aging also continues to rise at an unprecedented rate , giving greater attention to the implications of an older population.
The world's population is aging , and simultaneously , the prevalence of diabetes mellitus worldwide is rapidly increasing.
The worldwide prevalence and incidence of diabetes and obesity are increasing in pandemic proportions.
The worldwide prevalence of AF is rapidly increasing owing to aging of the population.
The worldwide prevalence of diabetes mellitus is expected to reach @number@ million by @number@
The worsening efficiency of stress response with age represents a health risk and leads to the onset and accrual of major age-related diseases.
The wound scar was invisible in @percent@ of cases 3-6 months after surgery.
The wounds were measured using the method and photographed throughout the healing process.
The wrinkle and skin-surface roughness features were calculated and statistically analyzed.
The wrinkle improvement effects were evaluated at 1-week , 4-week , 8-week , and 12-week after the treatment.
The wrist , however , is probably the most socially-acceptable location for a monitoring device.
The writing stimulus was a four-syllabic word with one-to-one grapheme-to-phoneme correspondence.
The WRN gene encodes DNA helicase participating in genome maintenance.
The WT and FLNA-KO bones did not appear to age differently.
The WTMT enabled early detection , ( ie , borderline MCI ) of dysexecutive impairment , with @percent@ sensitivity and @percent@ specificity.
The XO generates superoxide anions and H2O2 for the self-defense system of the organism.
The XO inhibitors may prove to be promising antigout agents.
The X-ray attenuation and sGAG optical density were calculated by image processing.
The X-ray films showed that the average kyphosis decreased @number@ degrees at @number@ months after operation.
The XRCC1 399Gln allele was also associated with poor prognosis in stage II-IIIA and among older individuals.
The XRCC3 Met / Met genotype was significantly associated with increased risk of death among all patients and men in uni- and multivariate analyses.
They accounted for over @percent@ of global deaths and @percent@ of the global disease burden in @number@. [ @number@ ]
They all displayed a similar size close to @number@ nm.
They all engage the proteostasis network ( PN ) , to varying degrees in an attempt to mange cellular stress and restore protein homeostasis.
They all had a confirmed history of acute poliomyelitis and new impairments after a stable period of at least @number@ years.
They all received middle segment pancreatectomy for benign tumors of the amphi-neck of the pancreas.
They also appear to affect female postmating behavior.
They also asked subjects to provide confidence ratings for their identification decisions.
They also attributed equal importance to sexuality.
They also believed more firmly that their ageing processes would have both negative and positive effects on their lives.
They also called for enhanced communication and collaboration between police and clinicians.
They also challenge existing views that neural representations in the striatum focus on valence , showing instead a dominance of the anticipation of action.
They also completed psychometric ability tests and tests measuring script knowledge for everyday events.
They also completed two short scales assessing general self-efficacy and negative mood.
They also confirm that those not proficient in Canada's official languages are less likely to receive OAS benefits.
They also constitute a source of income through a means-tested noncontributory state-funded pension available at age @number@
They also constitute a very high social spending , which is estimated to increase in coming years , due to the aging of our population.
They also contact each dental office semiannually by telephone to update this information.
They also describe current strategies to avoid , diagnose , and manage complications if they do occur.
They also differ in how often they select the best strategy on each problem.
They also draw upon our approximate sense of complexity.
They also estimated the percentage of people that would share their memory of each event within their age group and the other age group.
They also examined whether age affects these indices.
They also experienced more pronounced atrophy in anterior thalamic regions and abnormal DT MRI indices of all cortico-thalamic tracts.
They also experience higher rates of smoking-related disease , although smoking had no mediating and no consistent moderating role in these analyses.
They also give hints on where the healthcare system might benefit from changes.
They also had fewer WMH than the HTN-Other group ( p = @number@ ) and those taking non-BBB-crossing ARBs ( p = @number@ ) .
They also had greater coherence within the frontoparietal network , as well as greater deactivation of the ventromedial prefrontal cortex and the amygdala.
They also had larger middle portions of ventricular bodies than those with the intermediate tertile ( P = 0.018 ) .
They also had more knee abduction and delayed peak knee flexion.
They also had persistent leukocytosis as well as low lymphocyte and albumin levels compared with uncomplicated patients.
They also had significantly higher glucose levels up to @number@ years before the dementia diagnosis ( P = @number@ ) .
They also had significantly higher rates of healthcare utilization.
They also illustrate the usefulness of a strategy approach in a domain where it had never been formally used before.
They also imply a multiple origin for the BDNF-LI of the human cerebellum.
They also included non-modifiable variables such as gender and age that can be addressed through increased awareness and targeted health promotion.
They also increased the acetylation level of α-tubulin , indicating that SIRT2 is likely to be the target in cancer cells.
They also indicate that physical activity partially protects from the effects of ageing on muscle phenotype , mitochondrial content , and lipid accumulation.
They also inform about new approaches to delay cataract and other protein precipitation diseases.
They also investigated the relationship between ISLD and aging , disc / facet joint degeneration , and lumbar segmental motion.
They also lend support to research that has shown age-related effects in ambiguity resolution.
They also made a high proportion of trips by foot , although these did not together serve to meet physical activity guidelines for most.
They also need more protein to offset inflammatory and catabolic conditions associated with chronic and acute diseases that occur commonly with aging.
They also note a range of mechanisms to enhance such systems going forward.
They also offer clues to potential biological factors that may promote resistance to age-related involutional changes in the structure and function of the brain.
They also perceived the community as ready to address the issue and recognized some organizations already championing efforts.
They also performed better on TOJ and phonological awareness than dyslexic readers.
They also performed the False-belief test addressing cognitive theory of mind and the Reading the mind in the eyes test addressing affective theory of mind.
They also performed the Trail Making Test @number@ min after the intervention in each condition.
They also present a series of simulation models that purportedly show how the HAPC models estimated by Reither et al.
They also presented with more advanced disease , but this did not translate into a difference in survival rates.
They also provide a common metric for exploring the effects of adaptation within different observers or different environments.
They also provide evidence in favour of the hypothesis that higher-order colour mechanisms are equipped with flexible cone weightings , as opposed to fixed weights.
They also provide profiles of depressive symptoms that may more accurately characterize risk for specific types of abuse.
They also received lower scores on the @number@ complex conditions of the receptive language task.
They also reduced their false alarms and adopted more conservative response criteria during a recognition test ( Experiment @number@ ) .
They also regulate circadian rhythms and the way that we feel pain.
They also regulated the attention of younger toddlers more , and more often socially approved older toddlers ' helping.
They also reported an increase in presence and absorption with the virtual task , describing an external focus of attention.
They also review the application of these methods and concepts for the development and mechanistic characterization of Sirtuin modulators.
They also showed that this negative effect was mediated by dogmatism and social dominance orientation , which both exerted a positive effect on ageism.
They also show potent immunoenhancing activities in vitro and in vivo.
They also strongly agreed on using them as nutrients ( @percent@ ) .
They also struggled to accurately estimate the frequency and duration of their activities.
They also submitted themselves to the procedure and published films and books describing their experiences.
They also suggest improvements in short-term spatial memory were not due to changes in the neuropathological features of AD or monoamine signaling.
They also suggest that age differences in prefrontal gray matter volume are a significant contributor to age differences in self-initiated use of elaborative memory strategies.
They also suggest that healthcare professionals might need more training regarding the particular needs and concerns of this community.
They also suggest that MsrA uses multiple reducing systems for its repair activity that may augment its function under different cellular conditions.
They also suggest that proteins other than p62 are likely required for mitophagy downstream of Parkin substrates other than VDAC1.
They also support a hypothesized age-related deficit in processing low-contrast visual speech stimuli , even in older adults with normal contrast sensitivity.
They also support an increased role for nurse leadership in LTC pain management.
They also suppressed UVA-induced expression of c-Jun and c-Fos and the phosphorylation of three MAP kinases , upstream modulators of AP-1.
They also took a battery of cognitive tests.
The yam tuber is a traditional Chinese medicine used in long-term treatment as a juvenescent substance.
They analyzed data from @number@ monozygotic and @number@ dizygotic twin pairs from the Midlife Development in the U.S.
They analyzed the data using the principles of Grounded Theory and in-depth content analysis.
They appear to be not adversely affected by moderate physical activity.
They appear to be suitable for further confirmatory and validation studies , and show the potential to provide predictive performance for AD.
They applied a cream containing @percent@ nifedipine ( Antrox ; Bracco , Milan , Italy ) once daily for @number@ days.
They appreciated students listening to their life stories and documenting them through memoirs.
They are activated in response to stress , enabling them to guide skeletal muscle regeneration.
They are active sensors of their neuronal microenvironment and rapidly respond to various insults with a morphological and functional transformation into reactive phagocytes.
They are adopted to measure the structural complexity of the weighted graphs instead of the common binary graphs.
They are advantageous for research as the models are relatively straightforward to prepare and easily obtainable for research to perform surgical techniques.
They are a group of linked problems embedded in the structure of the communities in which they occur.
They are also classified as therapeutics against different types of human diseases.
They are also comparatively cheap and thus significantly reduce health care cost.
They are also effective to protect the retina against the high rate of oxidative metabolism observed in this tissue.
They are also found to contribute to skin aging and melanogenesis.
They are also involved in Alzheimer's disease , arthritis , and some cancers.
They are also less likely to use antidepressants but will metabolize zolpidem @percent@ slower than men.
They are also relevant in the context of BP treatment targets for older people.
They are also urged to actively intervene when opportunities for significant change arise.
They are applicable early in the course of illness when the person can still make end-of-life decisions.
They are assembled by modules via various non-covalent bonds ( hydrogen bonds , p-p stacking and / or van der Waals interactions ) .
They are associated with astrocytes which may modulate the effect of Aβ-deposition on the neuropil.
They are associated with many risk factors , in all health domains - physical , psychological , social , and environmental.
They are associated with stress hormones and key mediators of the regulation of homeostasis.
They are available for use stand-alone , or for integration with automated pipelines.
They are best understood as geriatric syndromes with close relation to frailty and other aging-related health problems.
They are called \ "complex disorders \ " and include cardiovascular disease , cancer , diabetes , and neuropsychiatric and neurodegenerative diseases.
They are capable of self-execution after a defined life span by both cell-specific mechanism and that resembling the cytoplasmic events in apoptosis of nucleated cells.
They are characterized by cognitive impairments along with neuropsychiatric symptoms , and that their pathogeneses show overlapping multifactorial mechanisms.
They are cognitive neuroscience-based in that they have been linked experimentally to specific brain systems with functional neuroimaging studies.
They are compelling because they elicit the desired sentiments of permanence , feeling ' at home' , and maintaining continuity in one's life.
They are considered a new class of endocrine regulators with promising potential as biomarkers.
They are conveyed by the lymphatics and blood circulation to cellular sites where they are endocytosed or incorporated into or transported by cell membranes.
They are derived from two of interRAI's widely used community assessments : the Community Health Assessment and the Home Care Assessment.
They are differentially expressed in the liver , thymus , muscle , intestine and skin.
They are distinct with respect to clinical signs , disease onset , disease duration , and diagnostic findings.
They are essential for the growth and regeneration of muscles.
They are falsely reassured by popular beliefs that advances in new reproductive technologies can compensate for the age-related decline in fertility.
They are hospitalized more frequently , have significantly more emergency department visits and use more emergent care.
They are implanted in the anterior corneal stroma of the non-dominant eye , most commonly , in a femtosecond laser created corneal pocket.
They are increasingly determined by low-grade inflammation , independently of central obesity.
They are involved in DNA synthesis , transcription , and replication.
They are known to be one of the major determinants of aging and longevity in higher mammals.
They are less likely to be HLA-DR3-positive and to relapse after treatment withdrawal after complete remission.
They are mainly heterochromatic and correlate with late replicating loci.
They are manifested in the temporal organisation of behavioural , physiological , cellular and neuronal processes.
They are members of the leucine zipper protein superfamily of nuclear transcription factors.
They are multidimensional and often include an exercise program to improve strength , mobility , and balance.
They are multimorbid.
They are not only elongated by reactivated telomerase but they are also epigenetically modified to be similar but not identical to embryonic stem cells.
They are often perceived to serve similar or overlapping roles.
They are out of their homes and interacting in the community , exercising and leading active lives.
They are part of the endogenous transcriptional response to SCA1 , and their effect is non-additive , suggesting participation in a similar mechanism.
They are pivotal to the processes of neurogenesis.
They are possible targets for new therapeutic drugs and interventions.
They are probably attributable to both environmental ( smoking and tuberculosis ) and HIV-related factors.
They are rarely drug-related but can be caused by a wide variety of medications.
They are released by infected cells within BM and can impact on neighbouring cells.
They are resistant to aging over several weeks.
They are responsible for the production of most extracellular matrix in connective tissues and are essential for wound healing and repair.
They are revealing a highly plastic barrier in which dynamic changes in BBB components like paracellular tight junction complexes can contribute to BBB maintenance.
They are subjected to physiological filtration pressure and considerable mechanical strain , which can be further increased in various kidney diseases.
They are summarized here in a diagnostic algorithm.
They are the best example of healthy aging in humans as most of them have escaped or substantially delayed the onset of major age-related diseases.
They are the part of important mechanism which is responsible for the process of aging and the development of many diseases.
They are the principal elements generating the hydrogen peroxide needed for TPO function.
They are the professional phagocytes of the brain and help orchestrate the immunological response by interacting with infiltrating immune cells.
They are the second leading cause of mortality in the general population , and the first in women.
They are thought to contribute to cancer , aging , and neurodegenerative diseases.
They are tightly controlled , as their activity is highly destabilizing and mutagenic to their resident genomes.
They are usually able to create at least reasonable integrity of the hybrid layer with high immediate bond strength.
They are usually based on \ "ad hoc \ " heuristic assumptions.
They are very likely to develop chronic obstructive pulmonary disease or similar disease later in life.
They are willing to use a variety of behavioral health services and perceive mainly practical barriers to using services.
They assemble to fibrous structures that are positioned between the inner nuclear membrane and the peripheral chromatin.
They assessed positively the applications although some of them showed resistance to incorporate it in their daily routine.
They assisted in the refinement of the methodology and collections and preparation of these data.
They attributed slower responses following invalid cues to the time needed to resolve the incongruent spatial information provided by the concurrently presented cue and target.
They believed that CG were an acquired , metaplastic lesion as a result of gastroesophageal reflux disease.
They believed that pain is part of life and a natural consequence of the ageing process.
They believe segregated housing to be undesirable and unsustainable , and perceive a need for alternative solutions.
They belonged to a cohort of @number@ healthy , full-term infants followed prospectively for the emergence of CMA.
They belong to a family of proteins consisting of FOXO1 , FOXO3a , FOXO4 and FOXO6 in humans.
They both apply the financing mode of individual premiums plus government's subsidies , and the voluntary enrollment.
They can also be due to reduced perivascular support , or capillary fragility and permeability , or a combination of all of these factors.
They can also be functional , however , particularly when provoked by drugs.
They can also be heavily dependent on exposure earlier in life.
They can also rebalance genome's function after genomic duplication events.
They can be called pathological or inflammatory scars.
They can be classified according to their nature and morphology.
They can be described as \ "collaborative care \ " or \ "person-centered care \ ".
They can be due to depression , cognitive decline , or be a part of normal aging process.
They can be solved only by understanding of what people do and why they do it.
They can be used to develop strategies to reduce country-level health disparity.
They can be useful for the application of Vestibular Rehabilitation ( VR ) , a technique improving the adaptation and autonomy of these patients.
They can cause significant disabilities such as phonetic problems and food or liquid regurgitation while swallowing.
They can cause what appears to be a type of vascular dementia years after surgery.
They can not only be used to construct biological age score equation , but also provide clinical targeted interventions for aging.
They can then diagnose the causal subtypes of these syndromes using standard criteria for each of them.
They can thus be useful to select the better treatment , either surgical or radio or hormone - or chemo-therapy.
They can transit from a ( so-called ) resting state under homeostatic conditions towards a pro-inflammatory activation state upon homeostatic disturbances.
They catalyze the NAD ( + ) -dependent modification of proteins with poly ( ADP-ribose ) .
They change how people interact with the environment , even as the environment changes.
They clinically manifest as cognitive decline and the subsequent development of dementia.
They completed a detailed demographic survey and a short standardized neuropsychological battery assessing psychomotor speed , attention , language , and memory.
They completed a questionnaire assessing immigration biography , service use and socio-demographic characteristics.
They completed each task @number@ times in total between the ages of @number@ ( years ; months ) and @number@
They completed each task @number@ times in total between the ages of @number@ ( years ; months ) and @number@
They completed five tests , measuring episodic and working memory pre- and post-intervention.
They completed measures of numeracy and need for cognition.
They completed physical and ophthalmic examinations.
They completed tests to measure baseline episodic memory , working memory , executive functions , perception , and language.
They completed the Sexual Health Inventory for Men and questions @number@ and @number@ of the IIEF15 were used to assess impairment in sexual desire.
They completed the Short Form 36-item Health Survey to assess HRQL and the nine-item Patient Health Questionnaire to assess depression.
They completed the VA subscale of the Profile of Mood States immediately before and @number@ min after the intervention in each condition.
They comprise traditional ( t ) NSAIDs and selective cyclooxygenase ( COX ) -2 inhibitors ( named coxibs ) .
They concern a population that is often elderly and with important comorbidities that complicate managing this already complex pathology.
They consisted of two groups young adults ( 20-29 years of age ) and older adults ( 70-89 years of age ) .
They constitute an intermediate stage in the transdifferentiation of alpha cells to cells that are functionally indistinguishable from conventional beta cells.
They constitute chronic low-grade inflammation environment to adjacent cells and tissues.
They constitute the safeguards of chromosome degradation and are responsible for maintaining genomic integrity.
They co-regulate stem cell properties such as potency , differentiation , self-renewal and senescence.
They could be isolated from the plants of Panax or other genus , as well as through the modifications of certain natural products.
They could therefore have a role in the development of vitreous liquefaction.
They demonstrated the ability to incorporate age-related changes within their identities and at the same time maintain a positive view of self.
They demonstrate similar effects on the length of life span , premature aging , and lipid metabolism.
They described their practice environments as hard and under-resourced.
They did not show any significant differences in osteogenic , adipogenic or chondrogenic differentiation.
They did not take any medication for ≥ @number@ months.
They differ in terms of the complexity attributed to the concept of neuronal vulnerability to Aβ.
They discussed regulatory issues , the challenges posed by trials of different types of interventions , and the need for standardization and harmonization.
They discussed the brain in terms of the cognitive operations that may either inhibit or improve speech communication.
They display high homology and may act in concert.
They do not consider health benefits of PA , for which solid evidence exists.
They do not die at the same age and also for different reasons.
They do not halt the progression of the disease.
They do not support that vascular pathology as measured by CBF and CVR negatively affects acute treatment outcomes.
They do suggest that Smartphone-based ABF system could be used for balance training and rehabilitation therapy in older adults.
They draw minimal financial resources from their CHC , and employ highly skilled staff to support implementation.
The year after assessment , among persons with prevalent dementia and any NH use , > 50% were a NH resident all days of observation.
The yearly rate of infective endocarditis ( IE ) in patient with a prosthetic valve is approximately @number@ cases per @number@ patients.
The years following parental death may initiate new circumstances through which the adverse effects of paternal death operate.
The years of life saved due to improved life expectancy could be worth another C $ 38.2 billion.
The yeast-hypha transition is an important virulence trait of Candida albicans.
The yeast LAG1 ceramide synthase gene was the first longevity gene cloned as such , and its orthologs hyl-1 and hyl-2 determine worm lifespan.
They either received a 35-min hazard perception training intervention or a placebo intervention.
They enable accurate outcome assessments in patients who undergo aesthetic facial procedures.
They erected an invisible but permeable barrier to limit access to their normal world.
They especially appreciated learning communication skills and seeing realistic videos.
They evaluated the assignment using an eight-adjective questionnaire and were asked about the benefits of the task.
They eventually arrest proliferation , differentiate , and fuse to damaged myofibers or make de novo myofibers.
They examined cultural idioms in participants ' accounts.
They exert protective actions against neurodegenerative disorders such as dementia and support smoothly functioning cognitive activities.
They exhibit distinct chromatin modification patterns , gene expression levels and replication timing.
They exhibited worse performances across measures of language and semantic function , and visuomotor function compared to participants with remitted epilepsy and healthy controls.
They experience every day fatigue associated with several changes in life due to age.
They experience longer waits for care and are less likely to be satisfied with their experiences.
They experience restrictions as a result of vision loss.
They feared losing their autonomy if they became dependent on help , and many therefore refused health service provisions.
They felt socially connected and experienced a sense of security in the community through caring for others and supporting each other.
They follow a sequential pattern and can serve as a blueprint for evaluating imaging studies of pediatric shoulders.
They formed the main part of a principal component that was related significantly to verbal and nonverbal memory , language comprehension and executive function.
They form networks with each other , and also have complex interactions with the cholinergic , glutamatergic , dopaminergic and GABA-ergic pathways.
They found that choice of treatment and a history of blepharoplasty were significant predictive factors that correlated with complications.
They found the physical activities useful , and they felt themselves to be included in a fellowship through cheerful nurses and volunteers.
They function well only if their constituents work in a complementary and harmonious way.
They further demonstrate that LRP1-GluA1 pathway may hold promises as a therapeutic target for restoring synaptic functions in neurodegenerative diseases.
They furthered categorized the projects within the taxonomy by ranking indicators with the greatest representation among projects and by ranking the frequency of specific measures.
They further have the potential to impact the development of therapies to safely treat AD.
They further suggest that skin biopsy may be useful to determine if protein farnesylation inhibitors are exerting effects in subjects with HGPS in clinical trials.
They generally also involve the generation of COX-1- and / or COX-2-derived products and the activation of smooth muscle TP receptors.
They had a comprehensive geriatric assessment which included clinical , anthropometric , laboratory and functional assessments.
They had a culturally constructed way of defining and characterizing mental illness.
They had a median ( IQR ) age of @number@ ( 17-29 ) years.
They had an age range of 15-85 years and were grouped by @number@ years.
They had an average hospital length of stay of @number@ days.
They had extended protrusions and more focal adhesions.
They had fairly extensive social and service supports focused primarily around family and the Chinese community.
They had had no recurrent chest pain , and had returned to the normal life they had had before the cardiovascular event.
They had had unexplained primary infertility > 2 years and a follow-up > 12 months.
They had lower mean diffusivity in the genu of the corpus callosum and the anterior thalamic tracts.
They had significantly lower rates of cancer ( @percent@ versus @percent@ ) and significantly higher rates of dementia ( @percent@ versus @percent@ ) .
They had very marginally lower employment rates , and those who were employed generally had lower incomes.
They hamper HBsAg-secretion and are associated with increased cellular proliferation , supporting their involvement in HCC-development.
They have a close relationship with Cotard's syndrome , delusional theme of organ denial observed in melancholic syndromes in the elderly.
They have also emerged as an important standard in the field of ageing and stem cells.
They have also revealed changes in the level of cerebral activation among persons with MCI who received this type of intervention.
They have an increased perioperative risk , but patients should not be denied surgery solely because of their age.
They have an increase of approximately @number@ times for developing stroke compared with subjects without diabetes.
They have a positive impact on daily life activities , depression , and QOL indices.
They have been extensively surveyed at age @number@
They have been hypothesised to be related to changes in the hypocretin system.
They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders.
They have been identified as cofactors in the progression of periodontitis.
They have been shown to attenuate and reverse the signs of photodamage , such as coarse wrinkling.
They have engaged several subspecialties , which have followed parallel paths in integrating geriatrics and aging research.
They have evolved to signal resilience to infectious disease and nutritional and social stressors , and they are compromised by exposure to man-made toxins.
They have fragile social networks that cannot supply the informal supports needed.
They have key roles in phagocytic clearing , surveying the local microenvironment and propagating inflammatory signals.
They have not often addressed multicomponent exercise interventions that combine strength , flexibility , balance and aerobic training.
They have shown to be beneficial in a broad spectrum of preclinical models of disease as well as in some clinical trials.
They have shown to possess potent biological activities in addition to their application as biomarkers of oxidative stress and inflammation.
They have superior survival , even when adjusted for RPA class.
They have the same scientific classification and are reported to have anti-inflammatory and many therapeutic effects.
They have to treat a potentially curative lymphoma , and concomitantly protect their patients from unacceptable toxicities.
They highlight the importance of forgetting processes in explanations of the amnesia.
They highlight the limitations of studies on aging that do not account for dementia in their subjects.
They highlight the need for improved COPD palliative care provision.
They highlight the need for reasonable prevention measures at the population level.
The yields were moderate , based on the starting aldehydes , while the reaction times were in general shorter than those reported in the literature.
They included bruising , tenderness , edema , redness , itching , pain , and changes in pigmentation.
They included modifiable variables , such as time spent sitting and mental health , which can be actively targeted in policy and practice.
They included @number@ participants from three different countries.
They include psychiatric , motor , and cognitive disorders.
They invade the brain early in development , transform into a highly ramified phenotype , and constantly screen their environment.
The Yiqi Huayu prescription can delay the degeneration of knee cartilage of HIF-1alpha cKO mice.
They later completed a questionnaire to assess their perception of the navigation system.
The YLLs were estimated by multiplying age-specific cancer deaths by the reference life expectancy.
They made a judgment of learning ( JOL ) after studying each word and then later had a free recall test.
They maintain only a few pathways for obtaining energy and reducing power for the key functions they need to fulfill.
They matched gender-typed objects to same-sex recipients , reproducing circumstances of possession and passing on expectations for gender identity.
They may also be particularly vulnerable to infectious complications requiring hospitalization , suggesting the need for careful monitoring during therapy.
They may also help to better understand compensatory mechanisms during the aging process.
They may appear several years after the injection , when the patient does not remember which product was injected , and treatment is often insufficient.
They may be associated with endocrine disorders , including hypothyroidism , diabetes mellitus , hyperinsulinemia and growth hormone ( GH ) deficiency.
They may even gain income if they buy stocks at low prices and get above-average rates of return.
They may lead to excessive digit forces and low stability of the grasped object.
They may lead to excessive muscle co-contractions and low stability of COP displacement.
They may mimic other dermatologic or systemic illnesses and may cause significant morbidity or mortality.
They may not know the range of available options , the relative benefits of each , or have considered their therapeutic goals.
They may serve as precursor-plaques for AD , implicating TBI as an AD risk factor.
They may substitute for inoperant ß ( @date@ ) -AR to mediate vasodilation in diabetic or atherosclerotic vessels.
They may thus be potentially useful in the prevention and treatment of skin photoaging.
They may thus be potentially useful in the prevention and treatment of skin photoaging.
They mentioned different solutions that could help them address their responsibilities in a reasonable manner.
They mentioned medication as the main therapeutic measure , despite its adverse effects and low efficacy and the way it was prescribed by physicians.
They modulate a wide range of biological processes , such as cell proliferation and differentiation , and can contribute to disease when aberrantly expressed.
They more frequently have problems in executing daily activities as compared with older adults from other European countries.
They more occurred in men and presented the trend of aging.
They need competencies in assessment of older adults and awareness of how illness may present differently in this population.
They need to be aware of the entire continuum of care and provide care coordination for patients who are not receiving specialized care coordination services.
They observed predominantly adhesive failures.
They obtained verbatim data from semi-structured interviews with eight participants recruited from London-based Chinese and church communities in Britain.
They occur as a result of preventable failures in the prescribing ( ordering ) , transcribing , dispensing and administration of medications.
They occur at low frequency because of the intrinsic variable nature of genomes , which we refer to as genome instability.
They often encounter challenges related to health care access and quality of care.
They often experience chronic fatigue and the usual physical and cognitive changes associated with aging.
They often have a significant relationship with sleep.
They often have impaired dynamic balance , which explains their increased falling risk.
The yoga training program consisted of Yogasanas , Pranayama ( breathing exercises ) , and meditation.
They only give evidence to support the association between psychotropic drugs and falls even if there is no proven link.
The young adult group had the greatest proportion of superfast-contracting MHCIIL isoform.
The young adult group was significantly more sensitive to linear than to circular gratings in the @number@ cpd frequency.
The young adult model of Karaki et al.
The young adults showed a slowing for all trials following bivalent stimuli.
The young brain is probably more susceptible to radiation-induced late cerebrovascular injury.
The young controls responded more quickly , and they made almost no mistakes.
The younger adults ' early old-new effects strongly resembled an index of perceptual fluency , suggesting that perceptual implicit memory was activated.
The younger and elderly groups were compared and correlation of RDW with clinical and laboratory parameters were analyzed in each group.
The younger dentists ' group achieved a significantly higher visual acuity with all magnification devices ( p < 0.001 ) .
The younger group felt more comfortable using the internet when compared to the older group ( @percent@ vs. @percent@ , p = @number@ ) .
The younger group included @number@ female and @number@ male students , and the elderly group included @number@ females and @number@ males.
The youngest cohort with diabetes had a higher rate of depression compared to those without diabetes ( @number@ vs. @percent@ ) .
The youngest donor cohort is overrepresented to a variable degree ; this tendency increased over time.
The youngest groups displayed irregular and thick cell clusters composed of poorly individualized cells.
The young favor the young , the old favor the old , and employers value the productivity of workers less than employees do.
The young group showed increased contralateral primary motor cortex activation for the more difficult somatosensory guided precision grip task.
The young-old adults presented larger speed discrimination thresholds ( perceptual experiment ) and larger walking speed errors ( walking experiment ) compared with young adults.
The young ones had more resilience related to social support.
The young patients had higher HRR after exercise.
The young subjects , but not the elderly subjects demonstrated an additional anterior cingulate deactivation when perceiving unfamiliar stimuli.
They participated in a 4-diving protocol.
They participate in a different repair processes such as base excision repair and non-homologous end joining.
They peak during the proestrous phase and also at puberty , simultaneous to a sharp increase in preference for fat to meet energy demands.
They performed a visuomotor adaptation task under 60° rotation of visual feedback.
They performed the test three times with 1-min intervals ( one trial was @number@ sec ) .
They perform functions in the maintenance of genome stability , and their mutation is associated with cancer predisposition and premature aging syndromes in humans.
They placed emphasis on access to anatomical spaces and compartments within the midface.
They plan on saving more in the future but change their mind and save less than initially planned as time passes.
They play important roles in DNA replication and repair and are central to our understanding of aging and cancer development.
They preferred to receive verbal information rather than collecting information from leaflets.
They presented with severe local inflammation ; thus , it was difficult to stop bleeding from the gallbladder bed.
They present with first signs of premature skin aging at an early age , with a considerably increased risk of developing UV-induced skin cancer.
They present with greater urgency and are more likely to be admitted to hospital or re-attend and utilize greater resources.
They promote individual confrontation with and social debate on a positive image of old age and aging.
They promote the mortality decrease and slowdown the development of pathology in the elderly.
They protect retinal ganglion cells in experimental models of glaucoma.
They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation.
They provided data on vision , hearing , and personality both at baseline and @number@ years later.
They provide detailed recommendations and concrete measures to assess risk and prevent falls among older people.
They provided serum for free estradiol , estrone , progesterone , free testosterone , and sex hormone binding globulin measurements.
They question the appropriateness of predictions about the lack of sustainability of our healthcare system.
They range from prevention , early detection and screening , comprehensive treatment both curative and palliative to comprehensive palliative care.
They rated their current status on these same goals again at @number@ and @number@ mo.
They rather aggravate PHN with time.
They reached forward , grasped or pointed to a target , and then returned to an upright posture as fast as possible.
They received a total of @number@ physical , morphological , physiologic and biochemical examinations.
They received @number@ doses of placebo , @number@ weeks apart , followed by @number@ doses of @number@ mg of alirocumab , @number@ weeks apart.
They received two training sessions ( session 1 : eight repetitions , session 2 : four repetitions ) , with a one week-interval between them.
They reduce irradiation- or chemotherapy-induced organ toxicities.
They reduce the penetration of damaging solar UV wavelengths in skin by reflecting or absorbing them.
They regarded managing personal health information easy while the older group struggled.
They repeated the tests after 1-2 days ( short-term ) and at @number@ weeks ( long-term ) .
They reported current mood and stressor exposure , as well as how long ago the stressor occurred.
They reported moderately high levels of burnout and a strong sense of their work's worth.
They reported that seeing their own face aged on the computer screen increased their perceived risk of skin wrinkling.
They reported the ease of website login and navigating within the test module together with many helpful suggestions.
They represent a subpopulation with a more unfavorable Kraepelinian course and have an increased risk ( up to @percent@ ) for dementia of unknown origin.
They represent less than @percent@ of all ovarian tumors , typically present in premenopausal women and frequently manifest with virilization.
They role-played the coaching process.
They seem to have a longer slanted-curve canal with one channel at its middle portion and a narrower incisive foramen opening than those reported elsewhere.
They self-reported their educational attainment and other demographics.
They serve to fix the facial soft tissue mass in loco.
They share a complex domain structure and have numerous binding partners in ECM and multiple cell surface receptors.
They shared their experiences of influenza , and influenza vaccination , and promotion of influenza vaccination in focus groups.
They shed new light on the phenomenon of telescoping and have implications for research on childhood amnesia.
They shorten each time a somatic cell replicates and this shortening is modulated by the effects of oxidative stress.
They shorten with each cell division , and therefore , telomere length is a marker for cellular aging and senescence.
They should be confronted with other more detailed studies in this work environment.
They should be investigated and treated in a similar way to abnormalities detected in younger individuals.
They should be provided with intervention programs to increase their physical activity at home.
They should be used as the basis for the development of local instructions for the management of nutritional problems and malnutrition.
They should receive intensive preventive care , including oral hygiene instruction and dietary advice.
They showed a rapid development of an alpha ERS that reached its maximal amplitude at around @number@ ms after stimulus onset.
They showed faster decline in memory , executive function , and processing speed.
They showed higher incidence of breast cancer ( BC ) when compared to either heterozygous and any P allele combination.
They showed highly significant increase ( P < @number@ ) when compared with control group.
They showed no marked changes in life-space mobility during the first year , but significant decline during the second year.
They showed strong synergies stabilizing the magnitude and direction of the total force vector.
They showed that the students rated themselves higher than the pharmacists.
They show moderate dependence at discharge , preferably returning to their own home.
They show overall that tPA protects white matter from stroke-induced lesions , an effect which may contribute to the global benefit of tPA-based stroke treatment.
They spent a mean of @number@ minutes using the decision aid and @percent@ preferred using their home / library computer.
They spent @percent@ of waking time sedentary , primarily watching television.
They subjected for morphological and radiometrical analysis.
They subsequently completed the PSQI at discharge , and @number@ months , @number@ months , @number@ months , and @number@ year post discharge.
They suggest functional impairment and the possibility that associated compensatory changes contribute to preserved memory functions in early AD.
They suggest that the OSTA should be tested in wild populations which might show effects masked in laboratory settings.
They suggest that there may be a neuromuscular basis for falls that could provide new insights into treatment and prevention.
They suggest that VSMCs require pulsatility to interfere with the coagulation process and highlight the relevance of plasma free TFPI levels to cardiovascular diseases.
They summarize their research work and review significant published papers.
They support the second and third stage in young persons for strategical components of adaptation.
They tended to be not working and were receiving a pension.
They tended to be widowed or live alone and had lower levels of haemoglobin and serum zinc.
They tended to show shorter RTs ( but no changes in accuracy ) with repeated presentations of the same face.
They then answered a series of questions that focused on memory details such as clothing , duration , weather , and so on.
They then engaged in written reflection about their photos.
They then estimated the number of additional items that they did not recall-a form of monitoring one's forgetting.
They then explore telomere biology and cell senescence.
They then need specialized transfusion of blood components / products , or purified blood extracted products or recombinant proteins.
They then show that restoring epidermal barrier function in aged mice reduces circulating levels of proinflammatory cytokines.
They then wore a tri-axial accelerometer ( Active style Pro HJA-350IT ) for 3-6 consecutive days to objectively measure their PA in free-living conditions.
They , therefore , could also be associated with differences of in vitro fertilization ( IVF ) outcomes , reported between races / ethnicities.
They , therefore , not only provide model systems to study normal aging processes but also give valuable insights into the intricate mechanisms underlying senescence.
They , therefore , require reminders in a timely fashion while performing ADLs.
They underwent 2D and Doppler echocardiography for assessment of left heart structure and function.
They underwent a complete general and neurologic examinations.
They underwent a detailed history and hormone study including total , free , bioavailable testosterone and estradiol.
They underwent clinical and cognitive testing and hormonal assessments of menopause status.
They underwent comprehensive MRI examination at @number@.0T.
They underwent magnetic resonance imaging and a comprehensive questionnaire to classify them as individuals with low or high CR.
They underwent , on average , four further imaging tests.
They underwent otoscopy and pure-tone audiometry and completed a questionnaire.
They underwent the CERAD-NB at a mean age of @number@ years.
They urged researchers to be mindful of research \ "burnout , \ " because many people with HIV participate in multiple research studies.
They used a range of coping strategies including ignoring , resilience and avoidance in such situations.
They used data collected from 14-16-year-olds ( n = @number@ ) and their parents ( n = @number@ ) in Norway.
They varied from @number@ ± @number@.9° at T2 to @number@ ± @number@.6° at L1.
They viewed neutral titles and indicated whether each title had been presented with an image during the study phase.
They viewed osteoporosis as a degenerative chronic disease with an overall stable course.
They wanted easier access to amenities.
They wanted fair and transparent funding arrangements and care that caters for diversity in Australia's older people.
They wanted high quality , accessible and respectful services that supported their independence and over which they had control.
They wanted reform to be soon and to have bipartisan support.
They were able to prevent , at least in part , both the cortisone- and the UV-mediated decreases in collagen content.
They were administered with a questionnaire in @number@ and the responses were compared with their 5-year survival status in @number@
They were allocated to @number@ groups encompassing subjects of different age.
They were all significantly greater in the old group than in the young and middle-aged groups ( P < @number@ ) .
They were all subacute onset.
They were also affected by more serious psychological and behavioral symptoms associated with dementia.
They were also asked if they experienced any fall in the last @number@ months.
They were also asked to assess their overall satisfaction using a 4-point scale.
They were also asked whether they would prefer to eat their meals in a day / dining room or by their bed.
They were also correlated to ethnicity and educations.
They were also more likely ( P = @number@ ) to have nutrition policy on home packed food.
They were analysed and are discussed in this paper.
They were analysed using qualitative content analysis.
They were annotated among others to genes involved in neuronal projections and neuronal development.
They were asked about barriers to and facilitators of ACP engagement.
They were asked to collect data on patients over @number@ years of age who underwent a fragility fracture in the @number@ months prior to recruitment.
They were asked to discuss a recent choice about services , focussing , amongst other things , on their use of information.
They were asked to listen to the program daily and baseline and follow-up measures of depression , QOL and loneliness were obtained.
They were asked to read congruent ( CON ) and incongruent ( INCON ) sentences to make semantic acceptability judgments.
They were asked to saccade to the scene containing an animal.
They were assessed at baseline , post-training and at a one-month follow-up.
They were assessed for their ability to independently predict quality of life at follow-up.
They were both closely associated with age and with cognitive test scores.
They were categorized according to treatment response.
They were classified as PiB ( - ) aMCI ( N = @number@ ) and PiB ( + ) ( N = @number@ ) .
They were classified at high , moderate or low risk of having osteoporosis according to the @number@ International Society for Clinical Densitometry official position.
They were classified into four groups ranging from normal hearing to moderate-to-severe hearing loss.
They were comfortable working with patients at the EOL when death was expected , particularly in dementia.
They were compared in a bipedal quiet stance reference condition and a bilateral Achilles tendon vibration condition.
They were compared with @number@ matched controls identified from the National Danish Patient Registry.
They were described in @number@ nursing activities , present during @number@ evaluations and repeated @number@ times.
They were divided into CSA ( @number@ patients ) and control groups ( @number@ patients ) .
They were divided into @number@ groups according to their ages.
They were divided into @number@ groups , each comprised of subjects ranged by age with a ten-year interval.
They were divided into seven groups according to their age.
They were divided into two groups according to age ( 6-10 years and 11-15 years ) .
They were divided into two groups according to sex ( male , n = @number@ female , n = @number@ ) .
They were divided into two groups according to the volume of ascites.
They were divided into two groups , with and without APOE4 [ E4 ( + ) and E4 ( - ) ] .
They were divided into young ( RESULTS : Kinematic curves showed good or excellent similarity in most parameters.
They were divided randomly into @number@ groups according to the proportion of 1 : @number@ by SPSS @number@ software.
They were first-generation offspring of parents with neovascular AMD.
They were fixed in @percent@ paraformaldehyde and the retinas cryosectioned and labeled against anti-4-HNE employing the immunoperoxidase method.
They were followed for a period of @number@ years ( mean @number@ years ) .
They were followed-up by telephone @number@ and @number@ months , post-ED discharge.
They were followed up for evaluation of outcome and detection of complications.
They were followed up @number@ @number@ and @number@ months after completing the treatments.
They were free of known risk factors for cardiovascular diseases.
They were from case-control studies , community-based prospective cohort studies , and studies that ascertained multiplex families from multiple sources.
They were given mesterolone @number@ mg / day per oral for two months.
They were grouped according to their clinical syndromes.
They were however , less likely to have an anxiety disorder , Alzheimer's disease or osteoporosis.
They were interviewed every @number@ months.
They were interviewed using the Dutch version of the Camberwell Assessment of Needs for the Elderly ( CANE-NL ) to identify met and unmet needs.
They were later expanded to include criteria for reducing the risk of chronic degenerative diseases for some nutrients.
They were less likely to have discussed preferences for end-of-life care ( OR = @number@ ) .
They were less likely to have modified work options available or be offered rehabilitation , despite having more severe injuries.
They were mainly published in the United States.
They were more actively engaged with services such as respite care.
They were more likely to have hypertension , arteriosclerotic heart disease , stroke , renal failure , manic depressive disorder , diabetic retinopathy or amputation.
They were more likely to smoke , have lung and heart disease , and report fair or poor general health status.
They were more satisfied with their lives , and had higher self-esteem.
They were mostly situated in the ' Intra-Personal Context and Wellbeing ' cluster.
They were not able , however , to adapt their learning time as efficiently as controls.
They were observed every @number@ years over six waves.
They were observed in the II aging group ( @percent@ ) for the first time.
They were originally known as nicotinamide adenine dinucleotide ( NAD ) -dependent protein lysine deacetylases.
They were outfitted with @number@ IMUs covering each body segment.
They were predominantly female and lived with the care recipient in the same household.
They were predominantly women and had a mean age of over @number@ years.
They were presented by region or macro area , globally or by gender , considering the most recent regional distribution and their time trends.
They were randomized into tai chi qigong ( n = 24 ) and standard care control ( n = 24 ) groups.
They were randomly assigned to two groups : the vehicle control group and the experimental group.
They were randomly presented with a photograph and asked to rate the photograph using a @number@ skin laxity scale.
They were recently shown to be essential for proper regeneration of skeletal muscles.
They were recruited as part of a longitudinal study and completed questionnaires reported here at the 18-month data collection time point.
They were recruited from different institutions caring for older patients in the north-western region of Switzerland.
They were recruited from the General Practice Clinic at the Clinical Hospital of São Paulo ( AGD-FMUSP ) .
They were recruited through a method of random generation of telephone numbers according to a sampling strategy based on geographic location.
They were requested to indicate the relative importance of the proposed parameters as well as the feasibility of obtaining the related information.
They were required to reach and grasp @number@ different pairs of cubes.
They were revisited in @number@ to @number@ days for assessment of the effects and possible touch-up injection.
They were significantly more common among subjects with MBs.
They were significantly more in the first years of experience , subjects younger than @number@ and who had touch-up injections.
They were similarly impaired on Penn Conditional Exclusion Test ( PCET ) outcome measures but differed in performance characteristics.
They were single case reports , small case series , or studies with a single-group pretest-posttest design.
They were subjected to continuous ambulatory monitoring of blood pressure , then the treatment was started.
They were tested with pure tone audiometry and Chinese version of HHIE-S.
They were then interviewed with either a Modified Cognitive Interview or a control interview followed by a recognition memory test.
They were then provided with instructions to use , depending on their experimental condition , suppression , reappraisal , or monitoring strategies.
They were then tested in tension in an Instron machine at @number@ mm / minute.
They were treated individually in case-by-case approaches , lacking randomized controlled trials and , mostly , treatment recommendations.
They were used to diagnose sarcopenia in the elderly.
They were workers in state and federal establishments in Ibadan North Local Government Area of Oyo State , Nigeria.
They will also contribute to a DPhil thesis.
They will also have implications in the development of geriatrics curricula and competencies specific to hematology / oncology training.
They wore actigraphy watches for @number@ weeks , from which measures of nocturnal sleep efficiency were calculated.
The Z codes increased the most , followed by endocrine diseases and neoplasms.
The zebrafish has proven to be a tractable model organism for studying both development and aging at the molecular genetic level.
The zeta potential of CTAB nanobubbles was @number@ mV , which was the highest among all formulations.
The zinc content was determined by flame atomic absorption spectrometry.
The zirconia frameworks rarely got damaged in many cases and complications often occurred in the veneering ceramic materials.
The zona glomerulosa ( zG ) was well developed in all @number@ patients ranging in age from newborn to the 30s.
The Zwolle risk score is useful for identifying subjects who may be safely discharged early.
The α5β1 integrin is a key fibronectin ( FN ) receptor that binds to RGD-containing peptides to mediate cell adhesion.
The α7 nAChR sensitivity to KYNA is age-dependent , because neither endogenously produced nor exogenously applied KYNA inhibited α7 nAChRs in slices from preweaned rats.
The αBC protein is phosphorylated on three serine residues S59 , S45 , and S19 , and several functions of αBC are modulated by phosphorylation.
The α-crystallins are small heat shock proteins while the β- and γ-crystallins belong to a superfamily that contains structural proteins of uncertain function.
The αMHC ( @number@ ) transgenic mouse model closely recapitulates human disease.
The α-oxoaldehyde methylglyoxal is a ubiquitous and highly reactive metabolite known to be involved in aging- and diabetes-related diseases.
The α point was reached slightly earlier for the young observers and with the outer stimulus but neither of these effects reached statistical significance.
The α ( v ) β ( @number@ ) -agonist , RGDS , latrunculin A , and an inhibitor of Rho-activated kinase inhibited HAS2 expression.
The \ "β-amyloid cascade hypothesis \ " of AD is the basis of current understanding of AD pathogenesis and drug discovery.
The β-amyloid peptide ( Aβ ) theory leaves much to be desired ; neurotransmitter and tau protein hypotheses are worth further examination.
The β-amyloid precursor protein undergoes cleavages by β- and γ-secretasses yielding amyloid-β peptides ( Aβ ) that accumulate in Alzheimer's disease.
The β-cellular expression of these cell cycle proteins was determined.
The β correlated significantly with age in all @number@ patients.
The β-galactosidase reporter staining assay showed that the effect of TSY-1 on Telomerase activity correlates with cell senescence.
The β point occurred earlier for the outer stimuli and this effect was statistically significant only for the older group.
The β-sheet structures were essential for Aβ-induced telomerase inhibition.
The β / α ratio correlates with the measured FGF-2 gradient , a morphogen critical to lens cell survival , proliferation and differentiation.
The γ-H2AX level was detected in NPC cells CNE1 before and after EBV infection using Western blotting.
The ΔE00 values were analyzed statistically by two-way ANOVA followed by the Tukey test ( p < 0.05 ) .
The ΔMTL was correlated with cognitive decline.
The ε4-allele appears to decrease the likelihood of reaching EL among individuals of different ethnic / geographic origins.
The ε4 allele of apolipoprotein E ( apoE ) gene is the strongest genetic risk factor for late-onset AD.
The ε4 allele of the apolipoprotein E gene ( ApoE ) is a genetic risk factor for late-onset AD.
The ζ-potential of Y-RBCs decreased gradually with aging.
The χ² -test and t-test were used to compare the results of the elderly group and the younger group.
The χ ( @number@ ) test , Student t test , and multiple logistic regression were applied for statistical analysis.
The χ ( @number@ ) test was used to evaluate the relationship between HGS and different variables.
The ω-3 supplementation group demonstrated a non-significant attenuation of the decrease in DXA quantified lean mass observed in the placebo group.
Thiamin concentration was below the reference range in 20 / 73 ( @percent@ ) of the participants.
Thiamine deficiency represents a common cause of both diseases.
Thiamine deficiency ( TD ) induces regionally specific neuronal death in the animal and human brains associated with a mild chronic impairment of oxidative metabolism.
Thiazide diuretics , statins , and calcium channel blocking agents were the most frequently studied drug groups.
Thiazolidinediones and canagliflozin should be avoided , whereas other sodium-dependent glucose transporter @number@ inhibitors are less well-validated options.
Thick actinic keratoses were gently curetted prior to ALA application.
Thick and / or long synovial folds were often evident in the CT joint.
Thickened vitreous cortex and perifoveal posterior vitreous detachment were physiologic findings in older individuals.
Thickness and sensitivity as primary outcome measures were mapped and superimposed correlating topographically differentiated macular thickness with sensitivity.
Thickness of nerve fiber layer ( NFL ) was measured in the sections , and the amount of neurofilament protein was measured by immunoblot analysis.
Thickness of the malar fat pads was measured.
Thickness was not affected by changes in muscle activity.
Thickness was @percent@ lower for males than females during quiet stance.
ThickNet features are extracted from the properties of a graph constructed from inter-regional co-variation of cortical thickness.
Thigh lean mass determined with a thigh scan on the DXA or full thigh MRI scans were compared.
Thigh muscle area and intermuscular , visceral , and subcutaneous adipose tissues were assessed with computed tomography.
Thigh muscle intraMF fractions , muscle area and strength , and function were compared between controls and ROA subjects , adjusting for age.
Thigh , shank , and knee range of movement in swing and stance were significantly different only in the > @number@ age group.
Thigh SM was estimated from an ultrasound-derived prediction equation using muscle thickness ( MTH ) .
Thin and stunted boys had one tooth less than normal boys at this age.
Thin films ( 200-μm thick ) were microtomed from wear prisms and then used for Fourier transform infrared spectroscopy oxidation and crystallinity assessments.
Things can be better.
Things can be better.
Thinner inner retinal layer measurements were associated with older age ( P = @number@ ) and greater axial length ( P = @number@ ) .
Thinner skins were more effectively treated than thicker skins because they could be stimulated throughout their thickness with the treatment parameters used.
Thinning and / or stiffening the SC increased both the surface and internal SC stresses.
Thinning was more widespread than volume loss , but volume loss , particularly in temporoparietal and hippocampal regions , was more strongly associated with cognition.
Thin plasma polymer films from ethylenediamine were deposited on planar substrates placed on the powered electrode of a low pressure capacitively coupled @time@ discharge.
Thin-section CT can demonstrate very early disease , sometimes in individuals without symptoms or pulmonary function test abnormalities.
Thin sections of the same crowns were used to assess periodicity histologically along with striae of Retzius distributions.
Thioflavine S staining and Nissl staining were used to characterize deposition of Aβ aggregates and neuronal degeneration in the transgenic animals , respectively.
Thiol homeostasis plays an important role in human health and aging by regulation of cellular responses to oxidative stress.
Thiotepa use was identified as a significant risk factor for permanent CIA ( odds ratio @number@ P = @number@ ) .
Third , age-related declines in ProM proper with focal cues are as large as age-related declines in recall measures of retrospective memory.
Third , anti-ROS therapy attenuates CAA-related microhemorrhage.
Third , AUF1 unexpectedly enhances the steady-state levels of several target mRNAs encoding DNA-maintenance proteins.
Third , based on logistic regression analyses , IM was the more effective predictor of T2D status.
Third , based on these considerations , recommendations are made regarding Social Security retirement benefit receipt alternatives.
Third , cholesterol biosynthesis was moderately decreased in TT1 cells , but was markedly decreased in TT2 cells.
Third , comparative studies are necessary to evaluate these systems in a standardized manner both in vitro and in vivo.
Third , DBDs that require the formation of multimers for target recognition are unlikely to modify targeting of ORF2p-driven insertions.
Third , FK-A11 selectively inhibits PI3K among @number@ common cellular kinases.
Third , gonadotoxic oncologic treatments allow many patients to survive cancer , at the cost of their fertility.
Third , graded differences in current L2 experience modulated L1 and L2 word processing in younger adults , but had no impact in older adults.
Third , how effective is phenotypic integration at establishing function across a population ?
Third , improved brain delivery of NTFs and new ways to stimulate NTF signaling are required to achieve clinical benefits.
Third , I offer an illustration of the methodologies using data for the United States.
Third , is there evidence of causality relationships between different affected regions in AD progression ?
Third , key stakeholders were engaged in a policy dialogue.
Third , latent mean differences between the two groups were tested.
Third , long-term caloric restriction has cardiac-specific effects that attenuate the age-associated impairment seen in left ventricular diastolic function.
Thirdly , design the fitness function based on the correlation criterion.
Thirdly , innovations in LTC services should be stimulated to increase productivity through technology and process innovations , and to reduce costs.
Thirdly , participants were asked to rate their subjective experience of each event recalled on a 5-point scale.
Thirdly , sleep-wake function ( SWF ) may influence the course and outcome of neurological and psychiatric disorders.
Thirdly , we stress that the research programme relating to the dimensional dsm-5 model of personality disorders should involve a larger number of older persons.
Third , no U.S. study has longitudinally examined cognitive health trajectories.
Third , patient satisfaction was surveyed.
Third , streamline loss occurred earlier in females than in males.
Third , studies on a newly discovered telomeric repeat-containing RNA are discussed in detail.
Third , surgeons searching for the prototypic technique have not had a way to index the physical signs of facial aging.
Third , that antagonistic pleiotropy acting on androgen-generated secondary sexual characteristics in men increased reproductive success earlier in life , but shortened lifespan.
Third , the MFS predicts a lateral-medial functional transition in eccentricity bias representations in children , adolescents , and adults.
Third , they accept government-imposed rationing as inevitable in the case of health care , as though the self-rationing alternative was unavailable.
Third , this kind of model hinders the overcoming of gender inequalities in intrafamily , generational , and social relations.
Third , to test for a genetic link , we sequenced the SAT1 gene and a rare but unique disease-associated variant was identified.
Third , to what extent do genetic factors influence variability in left-right size differences ?
Third , unlike involuntary autobiographical remembering , the frequency of future thoughts does decrease with age.
Third , we consider the functional consequences of age-related sleep disruption , focusing on memory impairment as an exemplar.
Third , we demonstrate alteration of these relationships in older adults , suggesting neurochemical modulation of cognitive flexibility changes with age.
Third , we discussed proposed treatments suitable to counteract or slow down ageing.
Third , we estimate the effects of adjusting benefits to reflect the increasing differential life expectancy by lifetime earnings.
Third , we examine the role of health behaviors as potential mediators of the association between major depression and cause-specific mortality.
Third , we found a within-person indirect relationship of social activity with episodic memory performance through physical activity.
Third , we found that introspection processes helped to explain the effectiveness of the interventions.
Third , we investigated the use of a population average fabric atlas.
Third , we observed no main effects of ApoE on EM or SM.
Third , we present a comprehensive discussion of AMPK during fibrosis and draw a conclusion.
Third , we provide an overview of our approach.
Third , we review the advantages of a developmental perspective in health psychology.
Third , we showcase a number of pharmacological agents previously employed in nonhuman primate studies that display some potential as caloric restriction mimetics.
Third , when widowers make decisions to repartner , wife sanctification does not appear to make an important contribution.
Thirst- and fluid-regulating hormones respond to both osmotic and volume stimuli.
Thirteen earlier studies are reviewed : these often had small sample sizes , and varied in educational level of older participants.
Thirteen factors were independently associated with an increased risk of adverse outcomes.
Thirteen female patients with solar lentigines on the back of the hands were enrolled.
Thirteen high-quality randomized controlled trials were included.
Thirteen individuals carried the T risk allele.
Thirteen items in three dimensions were used to evaluate relative deprivation of material conditions.
Thirteen items were identified by the logistic regression to predict drivers whose driving behavior was questioned by others.
Thirteen met the predefined criteria.
Thirteen MSA patients ( @percent@ ) and @number@ controls ( @percent@ ) had the heterozygous variant ( Val393Ala / NM ) of COQ2.
Thirteen older patients were compared to @number@ healthy controls.
Thirteen participants had cortical SS involving the cerebral convexities ( @number@ focal and @number@ disseminated ) .
Thirteen patients were diagnosed with delirium.
Thirteen patients with chronic condition ( s ) were enrolled.
Thirteen percent of NH residents with dementia concomitantly used ACBS levels @number@ or @number@ DAPs and AChEIs.
Thirteen ( @percent@ ) of the survivors reported significant physical health limitations in vigorous activities , as opposed to none of the controls.
Thirteen percent were malnourished ( MNA < 17 ) and @percent@ at risk of malnutrition ( MNA 17-23.5 ) according to MNA.
Thirteen RCTs met the eligibility criteria.
Thirteen relevant studies concerning @number@ trials were identified and included.
Thirteen studies met inclusion criteria , and @number@ major themes were extracted : experiences , causes , recovery , and barriers to treatment.
Thirteen studies reported that dual-task performance is a predictor of falls or falls risk in older adults.
Thirteen studies were included.
Thirteen studies were selected.
Thirty adult listeners were used to assess whether and at what age style differences were perceptible.
Thirty age-matched men with no ED or hypogonadism were enrolled as control group ( C ) .
Thirty consecutive patients were followed for an average of @number@ months.
Thirty-day emergency department visit rates and readmission rates were not significantly different between the two groups.
Thirty-day mortality was @percent@ ( @percent@ with EVAR and @percent@ with OR , P < 0.05 ) .
Thirty-day stroke and death rates , and length of hospitalization were compared between the symptomatic octogenarians and non-octogenarians.
Thirty deaths were attributed to coronary and cerebrovascular disease.
Thirty-eight deaths were due to cardiovascular disease , @number@ to senility , @number@ to respiratory disease , and @number@ to cancer.
Thirty eight fracture patients had depressive symptoms at @number@ weeks.
Thirty-eight healthy participants , aged between @number@ and @number@ were recruited.
Thirty-eight healthy young and older adult volunteers lay prone on an apparatus with shoulders flexed 75° and arms slightly flexed.
Thirty-eight subjects ( @number@ males , @number@ females ; ages @date@ years ) underwent MRI with a mixed turbo spin echo sequence.
Thirty-eight svMCI patients and @number@ SIVD patients were enrolled.
Thirty experienced older hearing aid users with typical age-related hearing impairment participated.
Thirty eyes were enrolled for each nuclear opalescence and cortical grade.
Thirty-five articles met the inclusion criteria.
Thirty-five healthy subjects ( age range 19-79 years ) were included.
Thirty five patients disclosed a total of @number@ problems ; @number@ ( @percent@ ) were rated by patients and physicians.
Thirty-five sex-biased genes were identified ( P < @number@ ) .
Thirty-five subjects ( @percent@ ) had serum B-12 levels < 150 pmol / l.
Thirty-four articles were identified , derived from @number@ studies.
Thirty-four meta-analyses were performed.
Thirty four% of IHD , @percent@ of vascular disease received the treatment other than medication.
Thirty-four of the @number@ patients met criteria for MCI.
Thirty-four of the proteins differentially expressed under ART treatment encoded hypothetical , uncharacterized proteins with unknown functions.
Thirty-four patients were diagnosed as having depression and the remaining @number@ patients were diagnosed as not having depression by the Mini International Neuropsychiatric Interview.
Thirty-four percent and @number@ % of those in community settings and RACFs , respectively , were not dispensed other analgesics in the previous @number@ months.
Thirty-four per cent of sites mentioned the number of patients treated while one quarter of clinics provided outcome data.
Thirty-four ( @percent@ ) of the forty-eight residents in the residency program participated in the SPCIT.
Thirty-four ( @percent@ ) were in group OP and @number@ ( @percent@ ) in group NOP.
Thirty-four right-handed participants of three age groups ( young , early middle-aged , and late middle-aged ) practiced @number@ trials of the task.
Thirty healthy , community-dwelling individuals median age @number@ ( range 60-67 ) were recruited from a certified Medical Fitness Facility.
Thirty healthy male volunteers ( @number@ ± @number@ years old ) were involved.
Thirty healthy men and women in three different age categories ( 23-30 , 41-54 , and 67-72 yr ) were included.
Thirty healthy older adults engaged with real and virtual tasks of similar motor demands : reaching to a target in standing and stepping stance.
Thirty lesions were identified on the initial MRI evaluation , of which twenty-three could be matched with histology.
Thirty male anatomy laboratory workers from various medical colleges involved with storing specimens and embalming were included in the study.
Thirty males who were not exposed to FA were included as a comparison group.
Thirty minutes after this experiment ended , post-test data were collected using the same scales.
Thirty minutes before Li-ESWT , each rat received an intraperitoneal injection of EdU.
Thirty minutes following the last stimulation bout , samples of diaphragm muscle were obtained from the anterolateral costal regions of the stimulated and inactive hemidiaphragms.
Thirty minutes of mechanical loading of a single knee joint in human subjects with knee OA resulted in a reduced COMP concentration in SF.
Thirty-nine instruments scoring near or above the 75th percentile were recommended.
Thirty-nine participants ( @percent@ ) exhibited a high Aβ burden.
Thirty-nine patients ( @percent@ ) completed the study.
Thirty-nine percent of studies utilized qualitative or mixed research designs.
Thirty-nine percent of the participants had MetS.
Thirty-nine percent of the participants with mild ID declined in ADL , @number@ % in IADL , and @number@ % in mobility.
Thirty-nine studies satisfied the criteria for consideration.
Thirty-nine unipolar depressed patients dosed using repeated DTM and @number@ matched patients treated with ABM were compared.
Thirty-nine women ( @percent@ ) exhibited a hypergonadotropic profile.
Thirty% of sexagenarians and @percent@ of septuagenarians had no morbidity and no impairment , @percent@ and @percent@ of them had no disability.
Thirty older adults ( M = 79 years ) underwent fMRI scanning and neuropsychological testing and completed a test of affective and cognitive empathy.
Thirty-one gray matter regions per hemisphere were assessed for abnormal hyperintensities.
Thirty-one ( HC = @number@ MCI = @number@ ) underwent β-amyloid positron emission tomography ( PET ) and magnetic resonance ( MR ) imaging.
Thirty-one healthy elderly were randomized into intervention ( n = @number@ ) and waitlist control arms ( n = @number@ ) .
Thirty-one male and thirty-five female adolescents aged ten to thirteen participated in a prospective study with up to five assessments.
Thirty-one normal sleepers completed the Karolinska Sleep Questionnaire and multiple home polysomnography recordings ( n = 2-5 ) .
Thirty-one patients participated in a telephone satisfaction survey.
Thirty-one patients ( @percent@ ) had a stroke recurrence , while @number@ patients ( @number@ ) were with poor functional outcomes.
Thirty-one patients ( @percent@ ) had underlying dementia , and @number@ ( @percent@ ) were agitated at the time of admission.
Thirty-one patients underwent surgery , and five patients were treated in urgency with laparoscopic peritoneal lavage.
Thirty-one patients were in Class @number@ to @number@ @number@ were in Class @number@ and @number@ were in Class @number@ to @number@
Thirty-one receivers and six non-receivers ( aged 67-91 ) participated in six focus groups in London , Ontario.
Thirty-one total hip arthroplasties ( THA ) and one total knee arthroplasty were performed.
Thirty-one were neutropenic.
Thirty participants did not start a program ; median attendance in the other @number@ participants was @percent@.
Thirty patients ( @percent@ ) showed thinness ( body mass index < @time@ / cm2 ) .
Thirty patients were treated conservatively , and @number@ patients underwent surgery.
Thirty patients with SAHS were divided into groups of @number@ according to disease severity : mild , moderate , and severe SAHS.
Thirty ( @percent@ ) had co-morbid chronic kidney disease or end-stage renal disease.
Thirty percent of the AD patients showed PA in the absence of MTA.
Thirty percent of trials had an exclusion criterion based on older age , and @percent@ excluded recipients aged @number@ years or older.
Thirty per cent were malnourished , @percent@ had evidence of behavioural disturbance.
Thirty preclinical and clinical medical student journalers participated in this project.
Thirty residents suffered from major depression at any point during the study , and @number@ residents had a history of depression.
Thirty-seven community-dwelling , Chinese adults aged @number@ and above were interviewed in focus groups and their accounts analysed and interpreted using a phenomenological approach.
Thirty-seven elders who live by their traditions participated in the present study.
Thirty-seven injured patients were matched with @number@ controls by the most responsible medical diagnosis , age , and gender.
Thirty-seven men ages 50 + completed the Male OPAQ™ and SF-12 at baseline and a two-week retest of the Male OPAQ™.
Thirty-seven men and women in the sample were sponsored by three religious organizations well known for providing humanitarian and disaster relief service.
Thirty-seven percent of patients were diagnosed with delirium , and @percent@ lacked decision-making capacity , mostly secondary to delirium.
Thirty-seven percent of those who have completed training are now in academic medicine , and program participants have authored or coauthored @number@ manuscripts.
Thirty-seven per cent taught a recognised classification of the domains of health used in Comprehensive Geriatric Assessment ( CGA ) .
Thirty-seven stroke-free , non-demented individuals ( 62-82 years of age ) were included.
Thirty-six common single nucleotide polymorphisms ( SNP ) were genotyped within a @number@ kb region encompassing the gene encoding sclerostin ( SOST ) .
Thirty-six DPGs were commonly upregulated by CAR activation regardless of age or species of CAR.
Thirty-six elderly individuals and twenty-two healthy young adults were asked to shift their centers of pressure ( COPs ) as far as possible while standing.
Thirty-six elderly people were evaluated using four tests : the Berg Balance Scale , Dynamic Gait Index , gait speed and tandem gait.
Thirty-six epilepsy participants were in remission and @number@ continued to have seizures.
Thirty-six female subjects aged 22-40 years enrolled in the study.
Thirty-six healthy older adults took part in the study.
Thirty-six healthy subjects , classified as young , middle-aged , or elderly , participated in the study.
Thirty-six miRNAs were differentially expressed between prenatal and postnatal stages of muscle development including several myomiRs ( miR-1 , miR-206 and let-7 families ) .
Thirty-six NS , @number@ SQ and @number@ UQ completed the imaging substudy.
Thirty-six of @number@ diabetic patients had complete resolution of diabetes within @number@ year.
Thirty-six older and @number@ young subjects were scanned while making relational judgments on word pairs.
Thirty-six patients were diagnosed as diabetics ( diabetic group ) and @number@ as non-diabetics ( non-diabetic group ) .
Thirty-six patients were included.
Thirty-six percent ( N = 96 ) of patients had clinical findings indicative of undetected illness.
Thirty studies had good methodology for at least one measurement property.
Thirty studies including @number@ shoulders met our criteria.
Thirty ST were randomly selected , with ×40-objective , for each case.
Thirty subjects ( @number@ subjects with PD and @number@ healthy control subjects ) were asked to walk using their natural , preferred gait pattern.
Thirty subjects with frank diabetes mellitus who received medications also had AD pathology scores that were similar to those of the cohort as a whole.
Thirty-three coronal brain slices of @number@ individuals with neuropathologically confirmed dementia were subjected to a high-resolution postmortem @number@ T MRI protocol.
Thirty-three ( mean age [ SD ] = @number@ [ @number@ ] years ; @percent@ female ) older adults with slow gait participated.
Thirty-three men ( isoflavones = @number@ placebo = @number@ ) undergoing ADT for PCa completed this pilot study.
Thirty-three of these children subsequently donated BM.
Thirty-three older adults returned for the 1-year follow-up session , and @number@ of them returned for the 3-year follow-up session.
Thirty-three participants diagnosed with SAD attended in a 10-week CBGT and were scanned before and after therapy.
Thirty-three participants divided into two age groups ( @number@ young , @number@ old ) participated in this study.
Thirty-three patients ( @number@ % ) died ; most ( @number@ % ) were middle-aged ( 50-65 years old ) .
Thirty-three patients ( @percent@ ) underwent EVAR and @number@ ( @percent@ ) had an OR.
Thirty-three patients with OSAS were compared with thirty healthy controls.
Thirty-three percent and @percent@ of patients were classified as malnourished and at nutritional risk , respectively.
Thirty-three percent of consultations were for patients who required intensive care.
Thirty-three preclinical studies provided evidence supporting an adverse effect of nutritionally relevant high iron intake in neonates on brain-health-related outcomes in adults.
Thirty-three rural women were recruited to participate in semistructured qualitative interviews.
Thirty-three schools in the Tel-Aviv region participated in the study.
Thirty-three typically developing children aged 6-12 years took part in the study.
Thirty-three women had adrenal hyperandrogenism ( @percent@ ) .
Thirty-three women who emigrated from Vietnam to the United States after @number@ participated in audiotaped interviews.
Thirty-three young and @number@ older adults were instructed to reach forward as far as possible without losing balance.
Thirty two adults ( ages 22-77 ) , with hearing thresholds @number@ dB HL at octave frequencies @number@.25-8.0 kHz , participated in this experiment.
Thirty-two asymptomatic patients were examined using a @number@.0T MRI to determine knee cartilage T1 rho values.
Thirty-two human third molars were randomly assigned to four test groups ( n = @number@ per group ) .
Thirty-two of these patients were excluded from the analysis , leaving @number@ patients.
Thirty-two older subjects participated in seven @number@.5-h sessions conducted on separate days over a three-week period.
Thirty-two participants performed exercises designed to fatigue the ankle plantarflexors , knee extensors , torso extensors , or shoulder flexors.
Thirty-two patients with PCOS as well as fifty-three control subjects were enrolled after obtaining informed written consent.
Thirty-two percent of responders had injectable treatments prior to their facelift , reporting a mean of @number@ rounds of injectable treatments prior to pursuing rhytidectomy.
Thirty-two percent of the cohort met these criteria.
Thirty two ( @percent@ ) of the polyps were advanced.
Thirty-two per cent were prescribed an antipsychotic drug.
Thirty-two players began playing in adulthood , thereby termed ' old starters' ; players were otherwise termed ' young starters'.
Thirty-two studies were included in this meta-analysis.
Thirty- ve healthy subjects from seven aesthetic practices were evaluated , and data from each were incorporated in this case report.
Thirty volunteers consisting of @number@ premenopausal and @number@ menopausal women underwent the fMRI.
Thirty volunteers will be included as matched nonsurgical controls.
Thirty women ( mean age : @number@ years ) provided data up to M05.
Thirty young and @number@ aging bilinguals completed a cued language-switching task and a cued color-shape switching task.
Thirty young ( @number@ ± @number@ years ) and @number@ older ( @number@ ± @number@ years ) individuals participated in the study.
This 2-hour mandatory interactive educational offering improved student attitudes and knowledge about healthy aging and provided hands-on health promotion counseling experience.
This A1R signaling enhances A2AR-mediated neurodegeneration , and provides a platform for future development of neuroprotective agents in stroke , Parkinson's disease and epilepsy.
This ability improves endothelial function due to the increase in bioavailability of NO.
This ability is found to be impaired in normal ageing.
This ability is particularly important in older adulthood , when executive functioning abilities are known to decline.
This abrasion technique leads to clinically significant improvements in skin structure , quality , and appearance.
This absence has led to the criticism that PS1 mouse models are not valuable for the study of AD.
This accelerated loss of cortical tissue may represent a risk factor for premature cognitive and motor compromise if not dementia.
This acceleration would then inevitably lead to increased incidence of specific age-related neurological diseases.
This access to packaging or ' openability ' has become a significant issue for designers and manufacturers with the change in demographics as described above.
This accumulation of Aβ may contribute to the @percent@ reduction of photoreceptors found throughout life and the shortening of those that remain.
This accumulation of evidence suggests that moving beyond the mean will provide a complementary window into aging-related neural processes.
This acknowledgement of the multidimensionality of SE is favorable , as it illustrates the complexity of the construct and of what constitutes functioning in work.
This action cannot be successful without the active involvement of the elderly and without their acceptance in the society.
This action contributes to the skin's aging.
This action is probably due to their interaction-induced translocation from the nucleus , where the regulation of tau E10 splicing occurs , to the cytoplasm.
This activation is a hallmark of both aged tissue and senescent human cells.
This activation process is highly diverse and depends on the context and type of the stressor or pathology.
This \ "activation selectivity \ " was specific to those brain systems that were central to each of the tasks.
This activation was accompanied by a decrease of anti-apoptotic proteins and an increase of calpain activity.
This activity increases and decreases in aged rat cerebrocortical membranes and synaptosomes , respectively.
This activity is followed by inhibition of the PI3K-AKT axis that mediates IL10 suppression.
This activity is valid for continuing education credit until @date@ .
This activity level remained elevated in the AD groups.
This activity should take one hour to complete.
This activity was attenuated by desensitizing P2X receptors on smooth muscle.
This adaptational process includes changes in the number , size , and structural / functional properties of the myofibers.
This adaptation is likely due to CR itself , rather than to leanness , and may be involved in slowing the rate of aging.
This adaptation to hypoxic stress can fundamentally change with age , resulting in different responses between fetuses and adults.
This adaptive response involved changes in cytoskeletal structure , energy metabolic shifts towards glycolysis and selective alterations in transmembrane receptor activity.
This additional information may significantly influence decisions about rehabilitation , postacute care needs , treatment plans , and caregiver education.
This adds to the growing evidence that EZH2 is part of the protein machinery that shapes the aging epigenome.
This adds to the importance of there being a wide selection of active molecules in sunscreen formulations.
This AD-related change was associated with a slowing in SOP.
This advances mechanistic understanding of arterial stiffness among aged adults before clinical disease.
This advantage can be partially explained by age and sex differences and , to some extent , by differences in known risk factors.
This adversely affects the economy.
This AEP difference increased as mistuning ( as a second grouping cue ) decreased and remained evident when the IPD was the only grouping cue.
This afferent activity can be inhibited by antimuscarinics at the low concentrations obtained with doses recommended for clinical use in OAB / DO.
This age-associated molecular disorder-induced inflammation that accrues in the heart and arteries does not , itself , cause clinical signs or symptoms of CVD.
This age could be used to define medically advanced age in HIV-infected people.
This age-dependent alteration of decorin GAG may contribute to skin fragility of elderly people.
This age difference disappeared after controlling for educational level.
This age effect disappeared after training when compared YT and AT.
This age effect was less obvious for specific IgG levels.
This age-graded shift from internal towards environmental control is often associated with compromised performance.
This age group has certain risk factors due to decreased motor , sensory and cognitive functions and also has greater frailty and vulnerability to injury.
This ageing model was then applied to test @number@ TBI patients and @number@ healthy controls to estimate brain age.
This age-related binding deficit occurred even when older adults could discriminate old items from new items just as well as could young adults.
This age-related change decreases the vitality , youth , and expression associated with the aesthetically ideal face.
This age-related decline became stronger as lifetime adversity increased.
This age-related decline in associative learning remains even after adjusting for attention , spatial and recognition memory , and strategy use.
This age-related increase in cellular entropy is compatible with the disposable soma theory of aging.
This age-related positivity effect has been eliminated in experiments that have explicitly demanded processing of both positive and negative information.
This age-related variation should be taken into account in RNFL thickness measurements when evaluating patients for diagnosis and follow-up of glaucoma.
This aging mechanism exhibits striking quantitative analogies to what is observed in the statistical mechanics of glassy systems.
This aging of the population will increasingly pose challenges to the public health system.
This aging population will need to increasingly access community-based services.
This aided survival analysis using quartiles and Kaplan-Meier.
This aim was motivated by findings showing better context memory for emotional than for neutral information in older adults.
This ALDH , ALDH2 , is located in the mitochondrial matrix with much known about its role in ethanol metabolism.
This algorithm determined the daily NH stay evidence by MDS and SNF dates.
This algorithm may be applicable to other cohorts.
This allele also significantly influences each of two diseases , diabetes and cancer , in antagonistic fashion in different populations.
This allele-specific methylation is age-dependent.
This allowed for measurement of total decision-making and financial and healthcare decision-making.
This allowed for secondary prevention in high-risk multi-faller individuals and for updated facility care policies regarding a safer living environment for all residents.
This allowed us to identify a total of @number@ variants.
This allowed us to measure how adaptation to one age level affected the full continuum of perceived ages.
This allowed us to quantify regional variation as well as the impact of structural and parameter uncertainty regarding the transition probabilities.
This allowed us to selectively approach HSCs functionally affected by age.
This allows a \ "beads-on-a-string \ " arrangement of multiple VWA domains as observed for ten N-terminal domains of the collagen VI α3 chain.
This allows for example , to capture saturation effects as typically observed during brain development or degeneration.
This allows for more efficacious treatment of dermal defects , excess adiposity , and skin laxity.
This allows for the possibility of hope.
This allows repeated testing , within-subjects designs , and longitudinal assessments , which aid understanding of changes in hormonal milieu.
This allows stem cells to sustain homeostasis or to remodel relevant tissues in response to physiological change.
This allows us to control for general age-related modifications , possibly originating from vascular , atrophic or structural connectivity changes.
This also applies for the budesonide / formoterol fixed combination , thus allowing for the maintenance and reliever therapy approach.
This also helps to plan and develop similar services in other parts of the world.
This altered protein gains a neurotoxic function , through yet unclear mechanisms.
This alternative to traditional acute illness care can enhance access to acute illness care and should be integrated into population health programs.
This amount is generally stronger influenced by aging than by polymerization time or concentration of the gel.
This amount is @number@ to @number@ times less than the daily recommended parenteral Cr in adults.
This analysis accounts only for changes in the population's age structure.
This analysis also identifies that specific patient subgroups are more likely to experience food intake barriers.
This analysis attempts to \ "date \ " the progression of neurofibrillary tangles ( NFT ) using the spatial distribution of NP as a reference.
This analysis brings \ "aging with disability \ " into middle and older ages.
This analysis casts doubt on the hypothesis that younger school-age children actually lead influenza epidemic waves.
This analysis demonstrates efficient discrimination among these groups.
This analysis examined neurocognitive outcomes at least @number@ years after ART initiation.
This analysis explicates what family members learn during the process of providing end-of-life care.
This analysis focused on the distribution and associations of refractive , corneal and ocular residual astigmatism.
This analysis identifies @number@ BMI-associated loci ( P < @number@ × 10 ( @number@ ) ) , @number@ of which are novel.
This analysis included @number@ women who had adequate data on PA exposure and @number@ women for sitting time exposures.
This analysis investigates to what extent the self-enhancement values in the Schwartz taxonomy-achievement , power , and hedonism-can predict retirement behavior.
This analysis is highly reproducible and sensitive to subtle differences in staining intensities resulting from diverse cellular senescence pathways in culture.
This analysis of muscle power decline is only partially in line with the results of works based on clinical tests.
This analysis provides a better understanding of declining function over time , than could be provided by current health modelling methods.
This analysis provides new estimates of the size and characteristics of the older population across settings and examines unmet needs for assistance.
This analysis provides our main finding , namely that prescription of antihypertensive medication leads to a significant reduction in the risk of developing glaucoma.
This analysis revealed two networks differentially related to performance across age groups.
This analysis showed that @number@ of the @number@ identified proteins were linked to aging in muscle.
This analysis suggests genetic factors contribute to variation in neuroimaging measures in a population enriched for metabolic disease and other associated comorbidities.
This analysis underlines the need for caution when using unadjusted self-reported measures to study the effects of social capital on health.
This analysis used patient-level data from each study to assess the exposure-adjusted incidence rates of specific adverse events that occurred following initiation of study drug.
This analysis utilized data from subjects taking concomitant medications , focusing on those taking seven or more.
This analysis was conducted to determine whether bicarbonate supplementation , an alkalinizing treatment , improves insulin sensitivity or glucose control in non-diabetic older adults.
This analytic tool may be useful for a patient-based monitoring of cognitive decline.
This ancient metformin response pathway is conserved from worms to humans.
This and other results from this review suggest the value of geriatric assessments to identify older patients at the highest risk of cognitive decline.
This annual report presents information of diseases transmitted by mosquitoes in Australia and notified to the National Notifiable Diseases Surveillance System.
This antioxidant function preserves mitochondrial integrity and physiology , prerequisites for glucose-stimulated insulin secretion.
This anti-PCa response was accompanied with a significant decrease in Sirt1 in TRAMP prostate.
This antiproliferative effect , was significantly potentiated by coincubation with Zn ( 2 + ) in an additative manner.
This apparent ART advantage suggests that ART programs may be a vehicle for strengthening health systems for chronic care.
This apparent inconsistency can be solved by assuming the existence of two mortality regimes : \ "latent \ " and \ "manifest \ " aging.
This apparent interaction is sustained throughout S-phase.
This application expands treatment options in patients seeking rejuvenation of the aging hand and face.
This applied research programme will provide high quality evidence for an intervention designed to improve and sustain mental wellbeing in older adults.
This applies particularly to the effect of drugs on various senescence-prone cellular pathways.
This approach accounts for repeated measures in typical MRI studies of development and aging.
This approach allowed us to identify histone H2B and H1 specific-sites of oxidation and to distinguish the most affected residues for each histone.
This approach allows for maximum tightening of the platysmal bands.
This approach allows semi-Markov models in which survival after dementia depends on onset age.
This approach also takes into account the correlation among cognitive outcomes for building a more appropriate predictive model.
This approach can be also used to screen for siRNA able to perturb the expression of SASP components during OIS.
This approach can be extended to other blood-brain barrier proteins that might contribute to drug-resistant epilepsy or other CNS disorders as well.
This approach can be extended to other rare recessive disorders , thereby providing accurate diagnosis and facilitating the study of disease mechanisms.
This approach can be used to study how protein interactome changes during development or in any pathological state such as aging or cancer.
This approach can give a reasonable quantitative measure of methylation difference across multiple samples.
This approach characterizes independent changes in multiple outcome measures over time.
This approach differs from past studies which aggregated across populations or disease groups.
This approach effectively revealed the ion conduction mechanisms and their dependence on the conditions , i.e. , ion concentration and membrane voltage.
This approach enabled age-related trends to be evaluated bearing in mind the uncertainty in the prestretch.
This approach has been shown to be promising for improving wellbeing and reducing depressive symptoms among institutionalized older adults.
This approach has not been used on stair climbing gait data.
This approach highlights new elements for elucidating the alterations observed during aging and may lead to novel sarcopenia biomarkers.
This approach ignores age-related changes during the @number@ years in-between , implying that this period is uninformative.
This approach involves expression of the high-affinity OneSTrEP-tag , precipitation of lamin-protein complexes after reversible protein cross-linking and subsequent protein identification by mass spectrometry.
This approach is also highly acceptable to this group of patients , supporting further evaluation in an appropriately powered , event-driven clinical trial.
This approach is based on significant development of methods previously described mainly by our group that were optimized and complemented for this study.
This approach is compared with an alternative one using existing screening tools , validated in ED , to detect high-risk patients needing subsequent CGA.
This approach is consistent with previous findings that longevity conditioned on survival to the modal age behaves like a normal distribution.
This approach lays the groundwork for more integrated and productive population-based research about how historical transformations may affect women's health.
This approach may avoid lymphadenectomy in @percent@ of patients with a favourable impact on lymphovascular morbidity.
This approach may prove generally useful for modeling phenotypic consequences of candidate human pathogenic mutations in conserved signaling and developmental pathways.
This approach may prove useful for investigating dysregulation in blood flow.
This approach may reveal strengths and also expose health and social inequities that seniors might face upon their arrival home.
This approach might apply to the simultaneous evaluation of the AE risk of polypharmacy and aging.
This approach offers hypothesis-driven insights into the relationship between brain and behaviour in healthy ageing that are relevant to the general population.
This approach presents logistic problems and limits the possibilities for remote assessment , an important issue for these patients.
This approach provided a sufficient visual field for lesion resection and satisfactory cosmetic results for patients.
This approach provides an effective tool for the high-throughput identification of potential functional regions involved in epigenetic regulation.
This approach provides further information on autonomic control of blood pressure in women.
This approach provides unique insight into the mechanisms associated with changes in speech production with aging.
This approach reduces institutional care while supporting home- or community-based care and other services.
This approach requires modification of cascade mechanisms of signal transduction to apoptosis and responses to DNA damage.
This approach should be multimodal and seamlessly integrate other treatment approaches , including neurofeedback and transcranial electrical stimulation.
This approach showed significant differences between the Turkish population and populations with non-European ancestries , as well as between Turkish and Northern European individuals.
This approach to aligning therapies with patient preferences is likely to promote patient satisfaction , to limit morbidity , and to favorably affect healthcare costs.
This approach was inspired by the self-governance and community engagement model , with the knowledge , experience , and participation of community stakeholders.
This approach yields new insights into the health care needs of the elderly and will be helpful to health care planners.
This area of care currently represents a \ "black box \ " to practicing surgeons.
This arm research reports two categories of online adjustments ( see Gaveau et al. , Neuropsychologia 55 : 25-40 , @number@ for review ) .
This arrestin-focused network is closely associated with transcriptional control of cell growth and development.
This arsenal could be potentially employed for anti-aging interventions ( given that similar signaling molecules are involved in both cancer and aging ) .
This article addresses issues of mitochondrial role and function in mammalian oocyte and presents new approaches in studies of mitochondrial function in female germ cells.
This article addresses possible changes in Dutch employers ' behavior regarding the recruitment and retention of older workers during the last decade.
This article addresses some of the unique healthcare needs of the aging LGBT population with an emphasis on social concerns and healthcare disparities.
This article addresses that gap.
This article addresses the changing realities and growing concerns associated with the future of advanced practice nursing.
This article addresses the question of how creating an age-friendly city has come to be an important policy and planning issue in Portland , Oregon.
This article addresses this need and offers recommendations for translating science in this area into meaningful population level impact.
This article aims to address these issues.
This article aims to assess health-related quality of life ( HRQoL ) and its correlates for the elderly , using a cross-sectional study design.
This article aims to discuss whether these definitions provide clearer conceptualization of MCI and to highlight implications for research.
This article aims to identify and explore some of these changes and how they can have a significant impact on women's quality of life.
This article aims to identify research directions that clarify the basis of this association.
This article aims to present one surgeon's experience in successful fat grafting philosophy and technique.
This article aims to review current available science and literature to support the use of these cosmetic procedures as lasting antiaging treatments.
This article aims to review the pathophysiological concepts related to diabetic neuropathy in the elderly and the best treatment options.
This article aims to review the trajectory of the concepts of dementia in the world and Japan.
This article aims to summarize the discussions at the session for the benefit of a wider audience.
This article aims to systematically review previous results on all-cause and cause-specific mortality by country of birth in the Nordic countries.
This article also details the challenges that nurses face in the Middle East and outlines the preferable ways to overcome such challenges.
This article also discusses aspects associated with neurological , cardiac and orthopedic issues.
This article also highlights sex differences in these domains.
This article analyses the extent to which frailty and dementia are better understood in the context of new forms of insecurity affecting the life course.
This article analyses the levels of job satisfaction reported by older workers ( aged 50-64 ) with and without disabilities at a European level.
This article analyzes the clinical features of cayenne aspiration in the lower airway.
This article analyzes the impact of marital status and spousal employment on the timing of retirement in Germany and Spain.
This article argues that attempts to use HTA for healthcare rationing are likely to disadvantage older patients.
This article argues that this development should prompt a new focus in medical care.
This article argues that wealth uncertainty influences when couples choose to retire.
This article assesses whether better glycemic control is associated with better maintenance of lower-extremity function over time in older adults with diabetes.
This article assists the home healthcare provider to recognize the characteristics and vulnerability of the older adult as related to a burn injury.
This article begins to address the gap in the literature regarding the caregiving experience within the context of multiple chronic conditions.
This article briefly reviews the current state of the work and discusses a potential framework for moving to scale.
This article briefly summarizes what cryotechniques are capable of presently and in the near future , to separate fact from fiction.
This article builds support for effective change in geriatric professional practices and improvement in the elderly patients ' quality of life.
This article challenges the idea that cancer cannot be prevented among older adults by examining different aspects of the relationship between age and cancer.
This article challenges this proposition by investigating the driving-related possible selves of British older adults living in West London.
This article characterizes the human aging process from the perspectives of normal , pathological , usual , successful , and positive aging.
This article comprehensively reviews gastrointestinal issues that commonly afflict the elderly female population.
This article comprises @number@ studies that directly address issues of age differences on cross-modal emotional matching and explicit identification.
This article considers whether there should also be limits-and how we should approach that question-for men who require and seek medical assistance to become fathers.
This article contains a brief synopsis on nonpathological aspects of the neuropsychology of aging and cognitive health.
This article contains an error in the Discussion , under the Implications , Caveats , Future Directions heading.
This article continues earlier started theme on a substantiation of the programmed aging mechanism ( phenoptosis ) .
This article covers the most significant questions for rehabilitation of gastrointestinal oncology.
This article deals with a new theory regarding an intensive therapeutic approach targeting aged people.
This article defines dysfunctional aging as a convergent downstream result of multiple interacting system processes.
This article defines wisdom and despair as choices for cognitively intact older adults.
This article describes a Council on Social Work Education ( CSWE ) Gero-Ed Center BEL Project's activities and reports its final outcomes.
This article describes an award program sponsored by the U.S. Environmental Protection Agency for excellence in smart growth and active aging.
This article describes an innovative model for integrating research into a policy and planning agenda aimed to help neighborhoods become more supportive of older adults.
This article describes changes in eyebrow position in Indian women with aging.
This article describes CKD staging in the geriatric population and several common clinical presentations of renal disease.
This article describes how these concepts were developed.
This article describes its use for cosmetic facial applications.
This article describes key studies that highlight the merits and limitations of the CGA for the evaluation of older patients with cancer.
This article describes known associations among frailty and chronic diseases and introduces punished inefficiency as an explanatory framework for frailty.
This article describes our work with focus groups , one component of a multi-component study that examined factors influencing the physical activity of LTC residents.
This article describes policy issues related to chronic mental health disorders and the older population.
This article describes potential treatment regimens to address age-related behavioral problems , as well as a framework for investigating differential diagnoses.
This article describes psychosocial and interactional barriers and facilitators of treatment engagement among depressed older adults served by community health care settings.
This article describes the challenging journey of implementing Six Sigma methodology at a tertiary care medical center.
This article describes the current state of epidemiologic knowledge on CHD in HIV infection.
This article describes the design and conduct of this trial.
This article describes the diagnostic possibilities of research of NT-BNP level in blood of the patients of elderly and senile age with congestive heart failure.
This article describes the effect of ethnicity , gender , aging , and instrumentation on wideband acoustic immittance ( WAI ) .
This article describes the evolution of the Caregiver Empowerment Model ( CEM ) to explain and predict positive outcomes of family caregiving.
This article describes the first comprehensive PM training intervention.
This article describes the initiative and invites readers to provide comments and suggestions.
This article describes the link between fall risk and fracture risk in community-dwelling older persons.
This article describes the neurocognitive changes observed in normal aging , followed by a description of the structural and functional alterations seen in aging brains.
This article describes the @number@ families who exemplified adversarial caregiving at the first study and how their relationships unfolded and shaped long-term outcomes.
This article describes the population and outcomes of the REACH VA translation of REACH II into the VA.
This article describes the process of establishing an hourly rounding initiative in a health care facility.
This article describes the range of cancer patients in longterm care and provides a framework for clinical decision making.
This article describes the role of cross-sectional imaging for detailed assessment and preprocedural planning of aortic , mitral , and pulmonic valve interventions.
This article describes these potential nutritional problems and then discusses evidence-based assessment strategies and treatment modalities that target these problems.
This article describes the situation of Spanish people with dependency in activities of daily living.
This article describes the sources of patient dissatisfaction and the avoidance and management of complications related to facelift surgery.
This article describes the Swedish indicators for quality of drug therapy in the elderly , introduced in @number@ and updated in @number@
This article describes the technology and reports on the authors ' experience with it in clinical practice.
This article describes the two-process model of sleep regulation.
This article describes two state-of-the-art statistical methodologies for addressing missing data in longitudinal research : growth curve analysis and statistical measurement models.
This article develops a new model for understanding the aging experience.
This article discusses all of those , as well as other components of successful aging such as social network and socioeconomic status.
This article discusses developments of evolutionary mechanics , the consequent programmed aging theories , and logical inferences concerning biological aging mechanisms.
This article discusses epigenetic events that possibly produce cancer progenitor cells from predisposed cells by the influence of their environment.
This article discusses how to clinically evaluate lower lid deformities , how to formulate a surgical plan , the preoperative assessment , and surgical markings.
This article discusses issues that may help clinicians choose among these newer agents and individualize treatment appropriately.
This article discusses selected cardiovascular conditions that nurses encounter when caring for elders hospitalized in the intensive care unit.
This article discusses several techniques of minimally invasive Achilles tendon repair.
This article discusses simple , practical measures that can be used to reduce the risk of VTE , including good hydration and promotion of mobilisation.
This article discusses that the traditional analogy of an aging organism with a rusting ( albeit self-repairing ) car is misleading.
This article discusses the availability of data on individuals suffering from dementia in national studies on aging.
This article discusses the clinical experience published about the high prevalence of diseases in older PWH.
This article discusses the current concepts of age-related osteoporosis.
This article discusses the dynamics of hairline evolution and the phenotypic variations of the front and side hairlines in men and women.
This article discusses the experimental evidence supporting the neuroprotective relevance of these and related factors in the aging brain.
This article discusses the fundamental links among these diseases and how peripheral organ insulin resistance diseases contribute to cognitive impairment and neurodegeneration.
This article discusses the most frequently used lasers and chemical peels used to address these problems.
This article discusses the prevalence , economic impact , and stages of Alzheimer's dementia in humans.
This article discusses these recent advances in cutaneous stem cell biology.
This article discusses these results in relation to what screening is , when to screen and the barriers to screening.
This article discusses the various RF and IFUS technologies currently in use and reviews pertinent clinical studies evaluating their efficacy and safety.
This article discusses the ways in which artists have incorporated or failed to incorporate the aging process of their bodies into their art.
This article documents , for the first time , a correlation between the CCA and BA of the same subject , under the same conditions.
This article documents the high degree of fragmentation.
This article draws upon qualitative research that included joint interviews with @number@ men with dementia and their carers.
This article elicits why critical care nurses need to become aware of the pulmonary issues of older adults.
This article empirically tests this proposition using a newly created Subjective Aging Index ( SAI ) .
This article employs a novel application of established geometric morphometric methods to examine shape differences in adult regional facial bone curvature with age.
This article empowers frontline nurses to develop gerontological skills and meet the unique needs of our aging population.
This article ends with the article's most important note : how to initiate the conversation.
This article evaluated the construct and predictive validity of including persistent pain in phenotypic frailty measurement.
This article evaluates whether the FS method is suitable for studying decisions in gerontological research.
This article examines age-related changes in immune function that predispose elderly individuals to lung remodeling but focuses especially on lower respiratory tract infections.
This article examines breakthroughs in facial soft-tissue augmentation that have expanded the palette of options available to physicians.
This article examines experiences of chronological age.
This article examines general skin care for older people , including barrier function and changes associated with the ageing process.
This article examines older men's accounts of their depression experience from a social constructionist approach.
This article examines policy makers ' success at updating seven major policies to address caregiver needs.
This article examines possible interconnection between unhealthy overeating and the theory of programmed aging and phenoptosis.
This article examines recent worldwide ESRD incidence trends as well as population dynamics for their implications on ESRD treatment.
This article examines the assessment of acute pain in older people , as well as different approaches to and challenges in pain management.
This article examines the contexts and benefits of African American seniors ' participation in multipurpose facilities.
This article examines the currently available longitudinal data evaluating the effects of childhood obesity on adult outcomes.
This article examines the diffeomorphometry of magnetic resonance imaging-derived structural markers for the amygdala , in subjects with symptomatic Alzheimer's disease ( AD ) .
This article examines the distribution of wealth and then tests associations between elder abuse and wealth in Rajshahi district of Bangladesh.
This article examines the frequency and effects of DSI in older age and notes limitations in the evidence.
This article examines the impact of physiological aging on treatment decision making and toxicity management in older adults with cancer.
This article examines the impact of these binary notions , especially on transgender and gender-creative individuals , couples , and families.
This article examines the reasons older Spanish people participate in nondegree educational programs and the barriers they may face when they want to do so.
This article examines the relationship between income and health service utilization among older adults in rural and urban areas of British Columbia.
This article examines these consequences among aging , male Mexican American injecting heroin users.
This article examines whether the retirement patterns of older Americans have changed as a result.
This article expands upon the lead essay by further discussing the role of home care and the need for its integration into the healthcare system.
This article explores areas of importance in the context of advanced illness for practitioners of Islam.
This article explores areas where the primary care of women with HIV may differ from that of aging women in the general population.
This article explores loneliness and isolation in older lesbians , looking at the benefits offered by an over-55 fortnightly social group in Yorkshire.
This article explores mutual caregiving between older spouses aging with physical disabilities.
This article explores race and immigrant disparities in health and health care access across the two countries.
This article explores recent evidence and important considerations for their use in treatment of VTE.
This article explores socioeconomic variation in HRR following exposure to a potent physiological stressor.
This article explores the benefits of RNs performing annual wellness visits ( AWVs ) for Medicare patients.
This article explores the continuing involvement in youth music and style cultures of older participants through examination of the case study of the goth scene.
This article explores the influence of health literacy on medication adherence.
This article explores the physiological changes in elderly surgical patients and the outcomes achieved after major abdominal surgery.
This article explores the topics of aging , ageism , heterosexism , and minority stress among older African-American lesbians.
This article explores this intersection through the well-being ( burden and self-esteem ) of caregivers to family members with dementia.
This article explores transgender aging , drawing from life story interviews with transgender adults aged 62-78.
This article exposes general classes of disease-modifying therapies under investigation.
This article focuses on evaluating during exercise asymptomatic patients with severe aortic stenosis and preserved left ventricular ejection fraction.
This article focuses on one home health agency's strategy to support nurse graduates transitioning from student to professional nurse.
This article focuses on research findings mining and results from an aging literature dataset.
This article focuses on the aesthetic concepts of volume loss and how to restore volume to mimic nature.
This article focuses on the prevalence , burden , clinical application , and management recommendations for the different types of UI.
This article focuses on the role of PAPP-A in mammalian aging.
This article focuses on updates in those involving peptides , growth factors , cytokines , and stem cells.
This article focuses primarily on the nursing aspect of the intervention and how it interrelates with the content and processes of the OT and handyman.
This article has multiple objectives.
This article hence sets out the objectives , needs , present scenario , strategies and types of dental treatment required by the elderly population.
This article highlights emerging data suggesting that increasing physical activity could be effective for reducing chronic inflammation in the elderly.
This article highlights geriatric demographic changes and illustrates how these and future trends will have wide ranging implications for the US health care system.
This article highlights recent clinical and experimental literature on sex differences in stroke outcomes and mechanisms.
This article hopes to provide a general overview that stimulates interest , better understanding , and continued joint commitment to the important subject of hypertension.
This article identifies both markers of disease progress and risk factors linked to the progression of MCI to dementia.
This article identifies ways in which nurses can contribute to the nutritional support of older cancer patients and thus help mitigate the effects of malnutrition.
This article includes numerous studies which evaluate prevalence , morbidity and mortality of thyroid cancer in older males.
This article introduces a new objection , one that develops out of the well-established disability critique of social contract theories.
This article introduces palliative care to cancer patients in Middle Eastern countries.
This article introduces the concept of socio-connective trust , the synapse between the social structures and processes that underpin relationships in supportive care networks.
This article introduces the core ideas of the INAPIC , its key research areas , and the available infrastructure.
This article investigated the nature and correlates of young , middle-aged , and older adults ' successful aging role models.
This article investigates how preferences for reform and its eventual design were shaped by the country's social history and commitment to free market values.
This article investigates the associations between the patient-centered care ( PCC ) and receipt of preventive services among older adults with chronic diseases.
This article investigates the causal relationship between the number of biological children and mental health of elderly Europeans.
This article invites the reader to consider pollution as a possible emerging etiologic agent for the development of melasma.
This article is about the avoidance of benzodiazepine medications by ' aging ' women living in a Brazilian village.
This article is addressed to endocrinologists treating patients with diabetic complications as well as to basic scientists studying an elusive link between diseases and aging.
This article is a Directed Reading.
This article is a Directed Reading.
This article is an update on current pharmacotherapy , advancements in biomarker use , and drugs in the pipeline for this disease.
This article is a review and synthesis of the articles in this supplement.
This article is a review of the available literature assessing the impact of age on atopy.
This article is a review of the available literature assessing the impact of age on atopy in the asthmatic patient.
This article is a review of the recent studies in this new field.
This article is a theoretical study which aims to articulate the notion of narrative identity in the process of aging.
This article is a U.S. Government work and is in the public domain in the USA.
This article is based on ethnographic fieldwork conducted between @number@ and @number@
This article is based on ethnographic research of the New York Museum of Modern Art's influential Alzheimer's access program , Meet Me at MoMA.
This article is important to facial plastic surgeons because it reveals how the results of rejuvenation procedures can be assessed.
This article is limited to aging as it relates to nurses employed in hospitals.
This article is one of a series , summarizing views expressed at the Orthopaedic Research Society New Frontiers in Tendon Research Conference.
This article is part @number@ of a 3-part series covering the role of oxidative stress in cardiovascular disease.
This article is part of a Directed Issue entitled : Energy Metabolism Disorders and Therapies.
This article is part of a Directed Issue entitled : Energy Metabolism Disorders and Therapies.
This article is part of a Directed Issue entitled Molecular basis of muscle wasting.
This article is part of a series \ "Beyond Amyloid \ ".
This article is part of a Special Issue entitled : 11th European Symposium on Calcium.
This article is part of a Special Issue entitled ALS complex pathogenesis.
This article is part of a Special Issue entitled < Auditory Synaptology > .
This article is part of a Special Issue entitled \ "Autophagy and protein degradation in neurological diseases. \ "
This article is part of a Special Issue entitled \ "Autophagy and protein degradation in neurological diseases. \ "
This article is part of a Special Issue entitled Biochemistry of Mitochondria.
This article is part of a Special Issue entitled : Biomarkers : A Proteomic Challenge.
This article is part of a Special Issue entitled Brain Lipids.
This article is part of a Special Issue entitled : Cofactor-dependent proteins : evolution , chemical diversity and bio-applications.
This article is part of a Special Issue entitled \ "Communication Sounds and the Brain : New Directions and Perspectives \ ".
This article is part of a Special Issue entitled Crystallin Biochemistry in Health and Disease.
This article is part of a Special Issue entitled : CV Ageing.
This article is part of a special issue entitled CV Aging.
This article is part of a Special Issue entitled : CV Aging.
This article is part of a Special Issue entitled ' CV Aging'.
This article is part of a Special Issue entitled \ "CV Aging \ ".
This article is part of a Special Issue entitled CV Aging.
This article is part of a Special Issue entitled CV Aging.
This article is part of a Special Issue entitled CV Aging.
This article is part of a Special Issue entitled CV Aging.
This article is part of a Special Issue entitled CV Aging.
This article is part of a Special Issue entitled CV Aging.
This article is part of a Special Issue entitled : Evolutionary principles - heterogeneity in cancer ? , edited by Dr. Robert A. Gatenby.
This article is part of a Special Issue entitled : Fibrosis : Translation of basic research to human disease.
This article is part ofa Special Issue entitled : Histone chaperones and chromatin assembly.
This article is part of a Special Issue entitled : Histone chaperones and Chromatin assembly.
This article is part of a Special Issue entitled : Histone chaperones and Chromatin assembly.
This article is part of a Special Issue entitled : Imaging Brain Aging and Neurodegenerative disease.
This article is part of a Special Issue entitled : insert SI title.
This article is part of a special issue entitled \ "Key Signaling Molecules in Hypertrophy and Heart Failure. \ "
This article is part of a Special Issue entitled : Membrane Lipid Therapy : Drugs Targeting Biomembranes edited by Pablo V. Escribá.
This Article is Part of a Special Issue Entitled : Membrane Structure and Function : Relevance in the Cell's Physiology , Pathology and Therapy.
This Article is Part of a Special Issue Entitled : Membrane Structure and Function : Relevance in the Cell's Physiology , Pathology and Therapy.
This article is part of a Special Issue entitled ' Menopause'.
This article is part of a Special Issue entitled ' Menopause'.
This article is part of a Special Issue entitled ' Menopause'.
This article is part of a Special Issue entitled ' Menopause'.
This article is part of a Special Issue entitled : Mitochondria.
This article is part of a Special Issue entitled Mitochondria in cancer , edited by Giuseppe Gasparre , Rodrigue Rossignol and Pierre Sonveaux.
This article is part of a Special Issue entitled Mitochondria in Cancer , edited by Giuseppe Gasparre , Rodrigue Rossignol and Pierre Sonveaux.
This article is part of a Special Issue entitled Mitochondria in Cancer , edited by Giuseppe Gasparre , Rodrigue Rossignol and Pierre Sonveaux.
This article is part of a Special Issue entitled : Mitochondrial Dysfunction in Aging.
This article is part of a Special Issue entitled Mitochondria : the deadly organelle.
This article is part of a Special Issue entitled \ "Muscle Bone Interactions \ ".
This article is part of a Special Issue entitled \ "Myocyte-Fibroblast Signalling in Myocardium \ ".
This article is part of a Special Issue entitled : Neuroactive Steroids : Focus on Human Brain.
This article is part of a Special Issue entitled : Neuroactive Steroids : Focus on Human Brain.
This article is part of a Special Issue entitled Neuro-glycoscience , edited by Kenji Kadomatsu and Hiroshi Kitagawa.
This article is part of a Special Issue entitled ' Neuroimmunology and Synaptic Function'.
This article is part of a Special Issue entitled ' Neuroimmunology and Synaptic Function'.
This article is part of a Special Issue entitled ' Neuroimmunology and Synaptic Function'.
This article is part of a Special Issue entitled : Neuromuscular Diseases : Pathology and Molecular Pathogenesis.
This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology.
This article is part of a Special Issue entitled : P13K-AKT-FoxO axis in cancer and aging.
This article is part of a Special Issue entitled : P13K-AKT-FoxO axis in cancer and aging.
This article is part of a Special Issue entitled : P13K-AKT-FoxO axis in cancer and aging.
This article is part of a Special Issue entitled : P13K-AKT-FOxO axis in cancer and aging.
This article is part of a Special Issue entitled : PI3K-AKT-FoxO axis in cancer and aging.
This article is part of a Special Issue entitled : PI3K-AKT-FoxO axis in cancer and aging.
This article is part of a Special Issue entitled : PI3K-AKT-FOXO axis in cancer and aging.
This article is part of a Special Issue entitled Proline-directed Foldases : Cell Signaling Catalysts and Drug Targets.
This article is part of a Special Issue entitled Redox regulation of differentiation and de-differentiation.
This article is part of a Special Issue entitled : Resveratol : Challenges in translating pre-clinical findings to improved patient outcomes.
This article is part of a Special Issue entitled : Resveratrol : Challenges in translating pre-clinical findings to improved patient outcomes.
This article is part of a Special Issue entitled : Resveratrol : Challenges in translating pre-clinical findings to improved patient outcomes.
This article is part of a Special Issue entitled : Role of the Nucleolus in Human Disease.
This article is part of a Special Issue entitled : Role of the Nucleolus in Human Disease.
This article is part of a Special Issue entitled SI : Brain and Memory.
This article is part of a Special Issue entitled SI : Brain and Memory.
This article is part of a Special Issue entitled SI : Cell Interactions In Stroke.
This article is part of a Special Issue entitled ' SI : CV Aging'.
This article is part of a Special Issue entitled \ "SI : CV Aging \ ".
This article is part of a Special Issue entitled SI : Memory Å.
This article is part of a Special Issue entitled SI : Memory & Aging.
This article is part of a Special Issue entitled SI : Memory & Aging.
This article is part of a Special Issue entitled SI : Neuroprotection.
This article is part of a Special Issue entitled SI : PSC and the brain.
This article is part of a Special Issue entitled SI : PSC and the brain.
This article is part of a Special Issue entitled \ "Stem Cells and Bone \ ".
This article is part of a Special Issue entitled \ "Stem Cells and Bone \ ".
This article is part of a Special Issue entitled : Translating nuclear receptors from health to disease.
This article is part of a Special Issue \ "Estradiol and cognition \ ".
This article is part of a Special Issue titled Brain Lipids.
This article is part of the 60th Anniversary special issue.
This article is part of the 60th Anniversary special issue.
This article is part of the 60th Anniversary special issue.
This article is part of the 60th anniversary supplemental issue.
This article is part of the series \ "Beyond Amyloid \ ".
This article is primarily concerned with the mesenchymal stem cells ( MSCs ) and it reviews the current aspects of their own niche.
This article outlines some advances in scientific technologies and new ways of thinking in science , which lead to new insights into skin biology.
This article outlines the design of this ongoing prospective nested cohort study.
This article outlines the history of autologous fat grafting.
This article poses some provocative questions and suggests some things that need to be considered.
This article presents a case involving a patient with an aging self-maintained provisional.
This article presents a general overview of the history of dementia research in Europe and how it compares with that in the United States.
This article presents a historical overview of the CHP system and their tasks and activities.
This article presents an emergent heuristic framework for the core environmental gerontology concept of \ "place. \ "
This article presents an integrative review of the empirical literature addressing self-concept in older adults.
This article presents an overview of the agents currently available for use in facial rejuvenation in the United States.
This article presents an overview of the classification , pathophysiology , emergency-department treatment and prognostic outcomes of drowning accidents.
This article presents an overview of the psychosocial factors that influence older people's participation in physical activity interventions to prevent falls.
This article presents an overview on the interaction of these two diseases.
This article presents a review of the structural determinants of vascular stiffening , its pathophysiologic determinants and its implications for vascular research and medicine.
This article presents cross-sectional data from the @number@ women , aged 60-70 years , participating in the HOW study in @number@
This article presents findings from a Multiple Correspondence Analysis of the British Regional Heart Study.
This article presents findings from case study research consisting of interviews with key employees at @number@ companies in @number@ states.
This article presents findings from two qualitative studies that demonstrate how older adults apply wisdom in new domains.
This article presents new norm values for the scales.
This article presents @number@ case reports involving patientspecific combinations of @number@ different HA products , injectable PLLA , and CaHA with incobotulinumtoxinA or abobotulinumtoxinA.
This article presents the data about state of health and immunity in veterans of extra risk divisions.
This article presents the data of @number@ patients ( @number@ men and @number@ women ) with mesangial proliferative glomerulonephritis , aged 22-70 years.
This article presents the design and implementation of this study.
This article presents the findings of a qualitative study developed to explore gay men's experience of aging with HIV.
This article presents the first measure of divergent thinking that can be used with children as young as @number@ years.
This article presents the first population-level assessment of nutritional risk based on a large national sample representative of Canadian householders aged @number@ or older.
This article presents the first stages of the Digital Knowledge Finder design , a case-based reasoning system to manage experience from the scientific literature.
This article presents the results of a study on the barriers and facilitators to bus use for people aged @number@ or older.
This article presents the results of the third phase , which consisted of a series of interdisciplinary workshops.
This article presents the set of tools and scores used in geriatric oncology to guide the therapeutic decision.
This article provides a brief overview of testosterone deficiency , TST treatment options and guidelines , and the risks and benefits associated with of TST.
This article provides a comprehensive discussion on the complications of blepharoplasty.
This article provides an introduction to enobosarm as a new therapeutic strategy for the prevention and treatment of cachexia.
This article provides an overview of aging in the criminal justice system.
This article provides an overview of management of advanced non-small cell lung cancer.
This article provides an overview of physiologic factors regulating PUFA utilization , highlighting their relevance to neuropsychiatric disease.
This article provides an overview of SIB , its underlying causes and functions , as well as other key variables associated with its manifestation.
This article provides an overview of social , biological , psychological , and cultural factors that contribute to African American women's health.
This article provides an overview of some of the assessment approaches that have been developed to assess this construct.
This article provides an overview of the epidemiology , pathophysiology , diagnostic challenges , and management recommendations for pneumonia in this setting.
This article provides an overview of the essential elements of orthogeriatric trauma surgery in elderly patients following proximal femoral fractures.
This article provides an overview of the main recent clinical evidence supporting the use of OM-based therapy in elderly patients with hypertension.
This article provides an overview of the mechanisms and regulation of autophagy , its role in health and diseases , and methods for its measurement.
This article provides an overview on progress and challenges of individualized and personalized health care in older women with breast cancer.
This article provides a personal reflection of lessons learned about ageing and gerontological nursing during the service-learning project.
This article provides a review of the current literature using structural and functional neuroimaging to identify MRI predictors of treatment response in LLD.
This article provides differences in the age of onset of breast cancer and death by breast cancer between women with and without a family history.
This article provides examples of assessment tools to utilize while assessing the older adults.
This article provides guidance on the most appropriate methods for communicating with patients who have limited vision.
This article provides information on the effects of female reproductive hormones and hormone therapy ( HT ) on fluid regulation and cardiovascular function during menopause.
This article provides the aesthetic provider with the basics of skin anatomy and how the skin changes over time.
This article puts forward a research agenda to fill the knowledge gap concerning lifelong causes of aging.
This article reports on one part of a three-part evaluation of a stepped wedge cluster trial.
This article reports on one part of a three-part evaluation of a stepped wedge cluster trial.
This article reports on our experience with the CO2 laser.
This article reports on the efficacy of a work-based learning program for direct care workers in assisted living.
This article reports on the findings of a study that explored older lesbian and bisexual women's access to publicly funded home care in Ontario.
This article reports the development and testing of the Successful Aging Inventory ( SAI ) .
This article reports the findings of an exploratory study examining service provider perceptions and experiences of addressing sexuality and intimacy with women spousal caregivers.
This article represents a review of published literature and summarizes the top seven proposed theories and their interrelation.
This article reviews all papers published since the inception of the initiative and summarizes the results as of @date@ .
This article reviews antimicrobial-induced AKI and discusses potential strategies for increasing awareness of AKI and mitigating its clinical effects.
This article reviews available nonprescription topical treatments for rejuvenation including moisturizers , antioxidants , retinols , and sunscreen.
This article reviews basic theory of treating diabetic wound and the changes in microenvironment , and prompts many successful cases in curing refractory diabetic wounds.
This article reviews current evidence regarding management of AMI in the elderly.
This article reviews essential features of SCD associated with preclinical AD and current measurement approaches , highlighting challenges in harmonizing study findings across settings.
This article reviews evidence on the complex interplay of stress , aging , and genes-epigenetics interactions.
This article reviews evidence that CR in nonhuman primates and people has a positive effect on risk factors for CVD.
This article reviews expected complications of surgery on renal masses and risk stratification schema.
This article reviews falls , mechanism of injury , and nursing care issues of particular significance to this vulnerable population in the critical care setting.
This article reviews in vivo confocal microscopy of the human cornea in health and disease and examines clinical and research applications of this new technology.
This article reviews material presented at the @number@ Scottsdale Headache Symposium.
This article reviews most common types of thyroid cancer focusing on older males worldwide.
This article reviews physiology , clinical manifestations , signs , symptoms , and treatment methods for atrophic vaginitis.
This article reviews recent data on vascular mechanisms that participate in the pathogenesis of stroke.
This article reviews recent links between steroid sex hormones and ageing , with special emphasis on the skin and wound repair.
This article reviews recently published literature on epidemiology , evaluation , clinical impacts , and management of OAB , with a focus on elderly men.
This article reviews relevant findings by each structural neuroimaging technique.
This article reviews several studies in which paintings , complemented by a pedagogical structure , allowed students to observe situations relevant to nursing.
This article reviews specific barriers to understanding the biology of aging and aging-related mechanisms that may underlie development of rheumatologic diseases in older adults.
This article reviews studies evaluating the use of topical tretinoin as agent for superficial chemical peel.
This article reviews the adaptive significance of the evolutionary biology of human male senescence with particular attention to population variation.
This article reviews the analysis and evaluation of the aesthetic patient presenting for periorbital rejuvenation.
This article reviews the associated controversies and limitations of polyphenol therapy.
This article reviews the available evidence on the efficiency and toxicity of targeted therapy for solid tumors in the elderly.
This article reviews the basic recording methods , scoring rules , and computer-based programs for PLMS.
This article reviews the behavioral literature on the control of goal-directed aiming and presents a multiple-process model of limb control.
This article reviews the causes and the consequences of anemia in the older individual.
This article reviews the clinical efficacy and safety of eldecalcitol in the treatment of osteoporosis.
This article reviews the clinical spectrum of frailty in older adults , its biologic etiology , and potential clinical interventions.
This article reviews the common forms of age-related memory change and the emerging evidence related to putative risk and protective factors for brain aging.
This article reviews the concept of reserve from its theoretical basis to the implication of reserve for clinical practice.
This article reviews the current literature and indications for a primary total hip replacement in these patients.
This article reviews the current state of treatment with PBCs and their associated risk for cardiovascular disease.
This article reviews the current understanding of the epidemiology of resistant hypertension.
This article reviews the current understanding of the prevalence and clinical significance of sarcopenia in transplant patients and highlights important areas of future research.
This article reviews the data summarizing basic information about PAPP-A with a particular focus on the significance of PAPP-A in renal diseases.
This article reviews the diagnosis and treatment of oral fungal infections.
This article reviews the diagnostic and treatment dilemmas encountered in elderly patients with tension-type headaches , highlighting both pharmacological and non-pharmacological interventions.
This article reviews the epidemiology , management , and therapeutic options for these conditions.
This article reviews the evidence supporting the use of antithrombotic drugs in elderly patients with ischemic heart disease.
This article reviews the guidelines and studies related to older people with T2DM worldwide.
This article reviews the important differences in the diagnostic spectrum of PIDs in adults versus children.
This article reviews the key anatomical concepts of midfacial aging , the evolution of midface-lifting techniques , and indications and contraindications for their use.
This article reviews the latest promising clinical advances that hold promise for assisting the prevention and treatment of depression , cognitive decline , and dementia.
This article reviews the literature investigating the utility of aerobic and resistance exercise training as an intervention for frailty in older adults.
This article reviews the literature on the efficacy and safety of corneal inlays.
This article reviews the multidisciplinary social science literature assessing the social consequences of medical treatment for male sexual dysfunction.
This article reviews the neuropsychiatric presentations elicited by spontaneous hypercortisolism and exogenous supraphysiologic glucocorticoids.
This article reviews the pathology , symptoms , and management of sleep disturbances in elderly patients.
This article reviews the pathophysiology and clinical presentation of aortic stenosis in this unique population and the critical role of various echocardiographic modalities.
This article reviews the pathophysiology of bone thinning in premenopausal and postmenopausal women , the impact of exercise , and the treatment options presently available.
This article reviews the pharmacologic and clinical profiles of BTX-A preparations currently available and in development.
This article reviews the physiologic receptors targeted by such drugs , common agents used , and specific clinical indications for their use.
This article reviews the physiologic response to resistance training in older adults and discusses the impact of resistance exercise training on cardiovascular risk factors.
This article reviews the pioneering achievements of PET in oncology with a focus on the development of PET that occurred from @number@ through the early-1990s.
This article reviews the potential impact of pharmacological agents , laparoscopy and other manoeuvres on POI in the elderly.
This article reviews the recent research progress of the pharmacotherapy for CAVD.
This article reviews the research on health promotion for adults aging with developmental disabilities.
This article reviews the scientific literature on the enhancement of healthy aging in older adults through active participation in the arts.
This article reviews these limitations and also describes techniques for performing fat transfer to attain safe and long-term aesthetic results in varied clinical settings.
This article reviews the state of knowledge and describes , briefly , these new treatment options.
This article reviews the state-of-the-science of sleep disorders in the context of psychiatric conditions in late-life.
This article reviews the symptoms and relates that VMS are of significant concern for the aging Asian women.
This article reviews the techniques that are available and the decision-making process in choosing the appropriate technique for the individual patient.
This article reviews UVR , its damaging effects on the skin and its relationship to UV immunosuppression and skin cancer.
This articles concerns itself with the testing of adhesion between direct restoratives and dental hard tissue , ie , enamel and dentin.
This article selectively highlights relevant areas of neuroscience research which have direct application for attachment theory and group psychotherapy.
This article serves as a review of the normal anatomy of the human aorta and its known age-associated changes.
This articles explores the perceptions of older Greek-Australians toward changes in the nature of family support.
This article's goal is to establish a method , a foundation and an instrument for carrying out the process of recognizing and identifying an individual.
This article shows that it is worth recognizing specific deficits and differentiating specific aspects in multifactorial disorders because many causes can be well treated.
This article studies how policies for older volunteers emerged in Germany and Italy , both countries having one of the oldest populations in the world.
This article suggests a series of steps to help determine the most appropriate approach for volume restoration with injectable devices for satisfying patient treatment expectations.
This article summarizes data about the possible molecular mechanism influencing rapid spreading of tumors in the elderly population.
This article summarizes the basics of macro and micro approaches to shear and tensile bond strength testing , as well as push- and pull-out tests.
This article summarizes the current developments in preventing dementia by modification of life style factors.
This article summarizes the currently available diagnostic and therapeutic tools and gives an integrated recommendation of how to manage CLL in @number@
This article summarizes the currently available diagnostic and therapeutic tools and gives an integrated recommendation of how to manage CLL in @number@
This article summarizes the different causes of cardioembolism and outlines current management guidelines.
This article summarizes the discussion ; highlighting progress , challenges , and new directions in the area of perioperative neurotoxicity in our aging population.
This article summarizes the evidence for and against viral cofactors in IPF pathogenesis.
This article summarizes the evidence regarding the impact of lifestyle behaviors on mortality among elderly people.
This article summarizes the important issues discussed at the meeting.
This article summarizes the in vivo experiments that elucidated molecular mechanisms associated with obesity-related hepatic inflammation and carcinogenesis.
This article summarizes the main conclusions drawn from the presentations on Helicobacter pylori at Digestive Disease Week @number@
This article summarizes the main opportunities and challenges that were identified during the meeting for defining WGs and WG foods internationally.
This article summarizes the partnerships created by the Department of Veterans Affairs Geriatric Research , Education , and Clinical Centers.
This article summarizes the recent literature and guidelines on the diagnosis and management of UTI and ASB in older adults.
This article summarizes these changes and provides key points for the practitioner to consider when caring for the aging patient in the critical care arena.
This article synthesizes and appraises the evidence for various types of compression therapies.
This article tests whether functional status is associated with likelihood of social contact among older adults.
This article , the first of a 3-part series , discusses the impact of poor oral health on elderly people.
This article , therefore , examines whether social disadvantage is related to various aspects of personal network change.
This article traces key methodological milestones in the application of epidemiologic methods since the earliest publications in the late 1940s.
This article used clinical assessment data to identify the predictors of and barriers to rehabilitation services for older adults in the Ontario Home Care System.
This article uses an ecological approach to illustrate individual and socio-environmental targets for the promotion of the cognitive health of seniors.
This article uses widow ( er ) hood statistics and census data from the Office for National Statistics Longitudinal Study.
This article will contribute to the understanding of the nature of Islamic spirituality and its immense importance in the life of a practicing ageing Muslim.
This article will discuss mainly vestibular damage and its implications.
This article will focus on HD and the evidence that it is a conformational disease.
This article will focus on how surgical techniques can be applied for male patients in particular.
This article will focus on potential risk factors for overuse injuries , including those that are intrinsic and extrinsic in youth athletes.
This article will focus on the assessment and interventions of sleep disorders in older adults.
This article will give a general overview of the models and risk factors that explain the development of physical disability.
This article will give an update on both the biological and clinical literature on dynapenia-serving to best synthesize this translational topic.
This article will outline the barriers and the steps that were taken to create systems change to promote and sustain advance care planning.
This article will review age- and health-related clinical considerations among individuals aging with I / DD.
This article will review historical as well as present approaches to resurfacing , discussing the nonablative tools that can complement resurfacing procedures.
This article will review some of these differences underlying the impact of food components on the risk of developing diseases from a sex-gender perspective.
This article will review the methodology of HRV measurements and contemporary knowledge about effects of acute alcohol consumption on HRV.
This article will review the state of men's aesthetic dermatology with.
This asks for a paradigm shift : away from single-disease-oriented patient management and toward patient-tailored multimorbidity medicine.
This aspect was also confirmed by cost analysis studies that reported similar data in both groups.
This assay is based on a comparison of fluorescent protein expression in NER-proficient and NER-deficient cells.
This assertion , however , primarily results from the comparison of data that were collected using different experimental procedures.
This assessment can be used by nurses to develop treatment plans and tailor management strategies to improve quality of life.
This assessment of static , dynamic , and elastic joint properties affords a comprehensive view of age-related modifications in muscle function.
This association and its potential therapeutic implications should be assessed in dedicated studies.
This association depended on C-reactive protein ( CRP ) levels ( p for interaction < 0.05 ) .
This association did not survive correction for multiple testing.
This association has important implications for primary and secondary prevention and can be easily assessed in clinical encounters.
This association is due to multi-varied pathways.
This association is important to consider in any study using DMN connectivity as a biomarker.
This association is influenced by HLA genetics known to regulate the immune response against HY antigens.
This association is less well-defined in normal cognition ( NC ) or prodromal AD ( mild cognitive impairment , MCI ) .
This association is mediated in part by microvascular brain injury.
This association is not explained by the use of sodium channel-blocking medication.
This association is not restricted to the links between vitamin D and calcium and bone metabolism.
This association is prominent in the subjects with normal nutritional status.
This association is required for the dopamine-mediated regulation of NKA.
This association is suggestive of the need that patients with MetS should be urged to have a screening colonoscopy.
This association is usually ascribed to aortic stiffening with age but the precise impact of low DBP per se is yet uncertain.
This association may arise due to confounding by depression or depression severity.
This association may be independent of human age.
This association may be magnified in the presence of high total cholesterol and low folate or vitamin B12 levels.
This association may be of particular interest to older people at risk for cognitive impairment and functional decline.
This association may be related to metabolic changes that transpire during sleep in OSA.
This association may explain thicker SFCT measurements in the morning than evening.
This association might be confined to younger participants.
This association needs to be confirmed following adjustment for co-morbidities.
This association persisted after adjusting for demographics , cardiovascular risk factors , and social network characteristics.
This association persisted after further adjustment for either occupational class and / or net wealth level.
This association persisted in analyses that further adjusted for health factors , depressive symptoms , and stress.
This association remained significant after performing Bonferroni correction.
This association remained significant for those with lower functional status.
This association remained significant independently of serum cholesterol exposures.
This association remained statistically significant after adjustment for other well-established risk factors for mortality in this population.
This association was also evaluated after stratifying according to use of dentures.
This association was attenuated upon additional adjustment for fasting TG.
This association was attributed to dysregulations in physiological stress systems and an unhealthy lifestyle.
This association was consistent across each level of pain severity on the Western Ontario and McMaster Universities Osteoarthritis Index.
This association was evaluated in random persons of age cohorts of @number@ @number@ and @number@ years in a 10- year longitudinal prospective study.
This association was evident in all age categories.
This association was found with the presence of dementia , heart failure , anaemia , stroke and auditory deficits.
This association was independent from the age-related slowing observed in control reading and naming tasks.
This association was independently replicated in the Chinese population , albeit with an opposite direction of effect.
This association was independent of age , sex , and number of chronic diagnoses , new chronic diagnoses , and new acute admissions.
This association was independent of age , sex , serum magnesium , and other potential confounders.
This association was mainly due to neglect and rejection.
This association was modified by age and body mass index , with the younger and leaner women showing larger decreases in AFC.
This association was not found comparing multi-tablet three-drug regimens and less-drug regimens.
This association was not replicated in an independent sample from the InCHIANTI and Framingham Heart Study.
This association was only significant for axial bradykinesia , but not for the presence of bradykinesia in the limbs.
This association was predominantly found in APOE ε4 noncarriers.
This association was present in individuals with and without CKD.
This association was robust to individual and combined adjustment for pulse pressure , mean arterial pressure , antihypertensive treatment , and chronic disease.
This association was significant and independent of smoking or air pollution.
This association was still significant in multivariate analyses ( p = @number@ @number@ @number@ and @number@ respectively ) .
This association was stronger after adjusting for other significant titers ( HR = @number@ 95%CI : @number@.5-6.4 ) .
This association was stronger for paragraph than word list delayed recall and in the oldest persons.
This association was stronger in older adults.
This association was though restricted to aerobic animals , whereas anaerobic animals showed variable cysteine accumulation.
This assumption has been challenged in the past , because of several cultural and scientific biases.
This assumption is based on biochemical evidence of activation of anabolic metabolism , with enhanced pentose phosphate shunt ( PPP ) and nucleotide biosynthesis.
This asymptomatic stage may be an opportune window for intervention to prevent progression to symptomatic AD.
This attempt to deal with telomere damage may be ultimately futile for aging fibroblasts but useful for cancer cells.
This auditory-frontal cortical deficiency , and hence cognitive decline , can now be objectively measured with the mismatch negativity and its magnetic equivalent.
This awareness originates from gerodontology.
This axis is designated as the prolactin / vasoinhibin axis.
This BACKGROUND : Various scoring techniques prone to subjective interpretation have been used to evaluate soft tissue augmentation of nasolabial folds ( NLFs ) .
This balance is changed during aging.
This balance may change with age , internal and external environments , and depend on genetic surrounding.
This basic question is especially true for liver resection ( LR ) .
This became a foundation for the Sister's generative commitment.
This became more evident when neural activation data were compared with that of young adults acquired in a parallel study.
This beneficial effect of digoxin was found to be not significantly different across age groups in those aged > 18 years.
This benefit covers frequent , brief , clinic visits designed to address older adult obesity.
This benefit is particularly important given the growing population of AL residents at risk for cognitive and self-care decline.
This BIA equation provides valid estimates of ASM in older Korean adults.
This bias is ameliorated with age , with older adults displaying either no strongly lateralised bias , or a slight bias towards the right.
This bidirectional relationship created a controversy in the field on whether arterial stiffness leads to hypertension or vice versa.
This bioheat transfer model is validated , capable to predict cardiovascular functions and thermal responses under varying environmental conditions.
This biosensor represents a unique tool to investigate carbon metabolism and bioenergetics in various cell types.
This blockage correlates with improved cognition despite compromised neurogenesis in the adult hippocampus was confirmed in mice lacking the E2f1 gene.
This bone-muscle relationship was more prominent in men than in women.
This bothersome condition occurs more commonly in the elderly.
This brief report examined how the likelihood of destructive anger responses varied with age across relationship contexts.
This brief review describes the necessity for , but risks of , NSAIDs in the older patient.
This brief review explores the role of energy and protein intake and other key nutrients on muscle function.
This brief review focuses on the current understanding of the complex role of visfatin in the cardio-cerebro-vascular system under normal and pathophysiological conditions.
This brief review is based on a President's Lecture presented at the Annual Meeting of the American College of Sports Medicine in @number@
This brief review shows the main clinical evidence of benefits induced by physical activity on erectile and endothelial dysfunction.
This brief review summarizes the current understanding of this entity and our studies aimed at further delineating its pathophysiology.
This Brief Symptom Screen can be used to quickly measure the overall symptom load in older adult populations , including those with multiple chronic conditions.
This brings into question the whole concept of the orally administering of antioxidant molecular species to down-regulate or abrogate an overproduction of free radical activity.
This \ "Ca2 + overload \ " hypothesis has been questioned by our theoretical analyses.
This cadaver study has increased the authors ' understanding of the perioral region and allowed them to improve results in its rejuvenation.
This calls for more interdisciplinary research between science and practice but also between scientific disciplines and between basic and applied research.
This camera circumvented the practical limitations of conducting retinal photography in the stroke ward setting.
This can at least partially , explain the higher inter-rater agreement in QSM.
This can be a cause for the development of many age-related diseases and appearance of phenotypic and physiological signs of aging.
This can be accomplished by expanding nursing and other providers ' scopes of practice.
This can be achieved not only through the quality of the diet , but also through the quantity of calories that are consumed.
This can be achieved through implementation of a 2-tiered model that incorporates a risk-assessment tool with utilization of a HF nurse educator.
This can be considered an adaptive behavior since fall-related injuries can have severe consequences.
This can be done on an individual ( health professionals adopting simple measures ) or institutional scale ( health institutions joining religious organizations ) .
This can be interpreted to mean that inner strength might have a protective effect against depression.
This can be in the form of cell culture , where specific celllines are cultivated , thus undergoing cellular senescence according to the Hayflick phenomenon.
This can be observed in humans as well as in mouse models of progeroid syndromes.
This can be of particular value in evaluating non-disabled older persons with chronic diseases but today no operational definition has been established.
This can be particularly challenging for complex interventions given their multidimensional and dynamic nature.
This can be used for shared decision making and to benchmark hospital performance.
This can explain the phenomenon of a \ "wandering pacemaker \ " and concomitant changes in the P-wave morphology.
This can explain why the mortality rate rises exponentially throughout the adult life in most animal species , including humans.
This can help in policy discussion on improving the lives of older people in the third age.
This can impair the functioning of the elderly in everyday life , work and social life participation and impair their quality of life.
This can lead to complications in undertaking everyday tasks such as using transport , bathing or even handling and opening food.
This cannot be explained by overlap in criteria and should be examined in future studies , primarily on its presumed clinical relevance.
This can range from pro-inflammatory , anti-tumorigenic M1 to anti-inflammatory , pro-tumorigenic M2 macrophages.
This can result in unnecessary polypharmacy and ineffective pain management.
This can trigger apoptotic cascades resulting in chronic inflammatory disorders.
This capacity declines with aging , and recent discoveries have redefined our view of why this occurs.
This care represents a significant time commitment for families and a significant economic cost to society.
This cascade , in turn , induced the expression of cyclin D1 and DNA replication.
This case demonstrates treatment and monitoring of an elderly patient with HIV and reveals the complications associated with this disease state.
This case describes a patient on chronic valproate therapy developing a severely disabling akinetic-rigid syndrome , only partially reversed on stopping valproate.
This case highlights that patients on hemodialysis should undergo proper clinical and instrumental follow-up in order to prevent or early recognize vascular access complications.
This case indicates that convulsion may cause false-positive RT-QUIC results , and that a postmortem evaluation remains the gold standard for diagnosing similar cases.
This case indicates that inadequate treatment and poor compliance may eventually result in rifampicin resistance in Mycobacterium leprae and clinical relapse.
This case is interesting because the severe NOMI occurred in a SPIDDM patient without common predisposing events such as hypoperfusion.
This case report describes an elderly diabetic patient with multiple ulcers of the lower limbs suffering wound-related pain.
This case report describes the effects of a comprehensive exercise program on an individual with DS who had sustained a stroke.
This case report highlights the importance of a meaningful forensic multidisciplinary investigation in such cases , and also discusses possible medical malpractice claims.
This case report suggests that all doctors should recognize the reference range for the serum creatinine level in teenagers.
This case series confirms the effective use of a semi-cross-linked HA gel in tear trough rejuvenation.
This case series highlights one of the complications associated with laser toning , which is facial depigmentation.
This case study illustrates the strong influence of cerebral plasticity as well as a possible circumscribed manifestation of interhemispheric disconnection.
This case study provides an in-depth examination of this process and efforts to optimize the role.
This case was finally diagnosed as the central nervous system involvement by age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorder.
This Caspase-6 mouse develops age-dependent spatial and episodic memory impairment.
This cation , called SkQ1 , is specifically targeted to mitochondria by electrophoresis in the electric field formed by the mitochondrial respiratory chain.
This causes a loss of strength and flexibility within the vaginal wall.
This causes a reduction in adenosine triphosphate produced by oxidative phosphorylation and an increase in adenosine triphosphate produced by glycolysis.
This causes big challenges for the public health systems , primarily in the field of surgery.
This CBSL program is a feasible and effective tool for teaching internal medicine residents and older adults.
This cell line was previously shown to exhibit circadian rhythms of clock genes.
This cell-specific signature will contribute to the identification and screening of novel treatments for this life-threatening disease.
This cell type showed efficient DNA repair , no mitochondrial damage , and resistance to long-term FR.
This cellular response called formaldehyde stress is dependent upon the concentration of formaldehyde.
This Center serves as a 2-way conduit of information and ideas between system administrators and providers.
This central position in metabolism endows acetyl-CoA with an important regulatory role.
This CH2 domain contains a very crucial S36 residue which is phosphorylated in response to oxidative stress and plays a role in apoptosis.
This challenges the health professional in choosing the best treatment.
This challenges the idea that the involuntary mode is uniquely associated with emotional distress.
This change brings important social , healthcare and economic consequences that call for a reorganization of patient care.
This change in hormone milieu has the potential to affect brain functions relevant to dementia and cognitive aging.
This change in lifestyle has been linked to an increased risk of diseases in all aspects of human health , including cancer.
This change in local connectivity resolves the paradox of opposing chromatin changes in senescence and progeria.
This change in shape has profound effects on protein function and is a major signaling mechanism in the cell.
This change in skeletal morphology may contribute to the appearance of the aging face.
This change in striatal activity was increased in young subjects , but reduced by comparison in older subjects.
This change is paralleled by an increase in nuclear area.
This change may be beneficial to understand some diseases , especially cardio-cerebral vascular diseases.
This change of doctrine may undermine the social mission of hospitals and the principle of solidarity.
This change signifies a risk for the bone's safety.
This change tended ( P = 0.07 ) to be different than the lack of change in non-structured activity observed following AEX + WL.
This chapter addresses a few of the research areas in which Drosophila has been used to elucidate the physiological functions of AMPK.
This chapter also critically evaluates miRNA-based therapeutic drug targets for aging and age-related diseases , particularly Alzheimer's.
This chapter begins with the discovery of satellite cells as skeletal muscle stem cells and their developmental origin.
This chapter builds on others in this volume , in which a deficit accumulation approach to frailty has been described.
This chapter considers the pragmatic integration of frailty in primary care.
This chapter covers the morphology and physiology of the genital area from infancy to old age.
This chapter discusses the endocrinology of the aging male.
This chapter examines connections between research in music , neurology , and psychology during the late-nineteenth century.
This chapter examines early cases of aphasia that include observations of the capacity to sing.
This chapter highlights the current achievements and obstacles in obtaining growing follicles through activation of dormant follicles.
This chapter highlights the rationale for combining biogerontology and cancer research to generate new strategies for cancer treatment.
This chapter highlights the recent progress in developing and testing mitochondria-targeted molecules using AD cell cultures and AD mouse models.
This chapter is divided into two sections.
This chapter is on biomarkers , mechanisms , and potential treatment of catecholamine neuron loss in Parkinson disease ( PD ) .
This chapter looks at each activity , asking what aspects are essential for axon survival.
This chapter offers a brief review of the signaling molecules related to TRPC channels , the first identified mammalian TRP family.
This chapter outlines commonly used methods to purify recombinant caspase-2 and assess its activity and function in vitro and in cultured cells or tissue extracts.
This chapter presents techniques for γ-H2AX detection in a variety of human and mouse samples.
This chapter provides an overview of the current telomere epidemiology research and discusses approaches taken in these investigations.
This chapter reviews preclinical and clinical pharmacokinetics of the following drugs : cyclophosphamide , docetaxel , doxorubicin , 5-fluorouracil , methotrexate and tamoxifen.
This chapter reviews the changes produced by age on various aspects of artistic painting , particularly creativity and actual production.
This chapter reviews the epidemiology , clinical features , and pathophysiology of ET.
This chapter reviews the history of palliative care and the elements of frailty that require the modification of current models of palliative care.
This chapter summarizes our current knowledge of epidemiological , clinical and treatment aspects of TB in particularly susceptible populations.
This chapter summarizes our strategic approaches , the major results we obtained so far and the main experimental and translational perspectives.
This chapter takes on the ambitious goal of describing dreaming across the lifespan , integrating both empirical dream research and clinical case examples.
This chapter will describe the immune / inflammatory alterations found in frailty and their putative causal relationships with this state.
This chapter will describe what computational modelling involves ; the rationale for using it , and the appropriateness of modelling for investigating the aging process.
This chapter will discuss the mechanisms by which environmental cues act through sensory pathways to influence hormone secretion and homeostasis.
This chapter will provide a concrete pathway for developing a data platform for studying and preventing insidious onset chronic diseases in this data era.
This chapter will serve as a guide for the diagnosis of multiple sclerosis ( MS ) .
This characteristic gave rise to the possibility that PiB could be used to trace WM pathology.
This characteristic is the responsible for its tumor suppressor activity.
This characterization has focused largely on describing age-accompanied differences in specialization at the level of neurons and brain areas.
This characterization , however , misses the most unique aspect of our species ; namely , an ability to invent technologies that reduce mortality risks.
This characterization is fitting considering over production of O2 ( -• ) / H2O2 by mitochondria is associated with range of pathological conditions and aging.
This checklist is developed based on validated instruments.
This chest wall defect was ultimately repaired with a latissimus dorsi flap.
This choice was assumed to trigger a stronger orientation toward the prevention of losses than the choice between travel packages.
This chronic phenomenon has been named \ "inflamm-aging \ " and is a highly significant risk factor for morbidity and mortality in the older persons.
This claim is debatable , however , because to date novelty has never been found in similarity sorting studies.
This claim is substantiated with quality score comparison of the gallery and probe pairs.
This classification correlated with self-reported health , chronic pain and depressive mood ( rank correlations @number@ @number@ @number@ all p < @number@ ) .
This classification could help health professionals select the RCF that best responds to older adults ' needs.
This clearly implies that other factors ( environmental , epigenetic and lifestyle ) contribute to lifespan and the rate of healthy ageing within an individual.
This clearly indicates that HGPS may truly represent accelerated aging , rather than being just a simulacrum.
This clinical assessment , which is crucial for individually tailored treatment , must be undertaken by a multidisciplinary team.
This clinical trial is registered at ClinicalTrials.gov identifier : NCT02798081.
This cochlear synaptopathy can be \ "hidden \ " because this synaptic loss can occur without permanent hearing threshold shifts.
This cohort coincides with the average age of transition to retirement in Australia.
This cohort effect was also at least partially confounded by survey design and health effects.
This cohort included @number@ white , @number@ African-American , and @number@ Hispanic participants who were randomly selected from the Women's Health Initiative CaD trial.
This cohort is part of a larger study examining the usefulness of the Treatment Initiation and Participation program to improve medication adherence.
This cohort represents the largest family-based GWAS of LOAD to date , with analyses limited here to the European-American subjects.
This cohort was initiated in 1997-1998 and exercise capacity was evaluated with a long-distance corridor walk test ( LDCW ) at baseline and Year @number@
This cohort were more likely to present as an urgent or primary PCI , underwent more complex interventions , and achieved less angiographic success.
This coincided with increased de novo arginine ( P < 0.0001 ) and increased NO production ( P < 0.05 ) .
This collaboration prepares faculty to address an aging population.
This color manipulation with younger adults was sufficient to lead to an increase in Stroop effects that mimics age-effects.
This column discusses brain function and \ "tips \ " for structuring teaching based on it.
This column includes a sample search and a discussion of additional AgeLine features.
This combination peptide therapy should therefore be tested in humans with HAND.
This combination was further tested in vivo.
This combined approach could be employed clinically to greatly enhance the speed and effectiveness of NMSC treatment in many cases.
This combined with microRNA-based tumour profiling could pave the way for personalised approaches based on the genetic characteristics of the individual.
This commentary addresses the complexities of fall prevention practices and offers solutions that can facilitate adoption by clinical practices.
This commentary addresses the underlying assumptions of these policy recommendations , identifies the major barriers to their implementation and suggests solutions.
This commentary begins with a brief history of the functional approach.
This commentary critically discusses recent legislation promulgated in Nepal to safeguard older people's rights and promote their well-being.
This Commentary discusses some lesser-known functional and regulatory aspects of IFs.
This commentary discusses the epidemiological and aging perspectives and their current limitations in providing an explanation.
This commentary discusses the intersection of human ovarian and somatic aging.
This commentary is an updated summary of the current methods used in these centers.
This commentary offers a set of approaches which may lead to progress in this field.
This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.
This common practice has not been validated to the best of our knowledge.
This common temporal emergence pattern suggests that slowing aging can postpone the onset of these maladies and alleviate their symptoms once emerged.
This comorbidity burden highlights the challenge of effectively treating heart failure while simultaneously managing co-existing and unrelated conditions.
This comorbidity is poorly understood.
This comparative study examined the effects of regular low intensity aerobic exercise on oxidative stress markers in older adults.
This compares with @percent@ , @percent@ , and @percent@ , respectively , for comparable clinical risk groupings.
This compares with @percent@ reported by Calce on 20th century North American material.
This comparison shows a consistency in the orders of ratings across the @number@ languages.
This compelling evidence has prompted the World Health Organization to recommend engaging in regular physical activity throughout one's life course.
This completely disproves the current hypothesis , because a supposed defense against a deadly disease cannot exterminate a population before the disease begins to kill.
This complex bound to three estrogen response element ( ERE ) half-sites on the Rorγt promoter region to suppress Rorγt expression.
This complex intervention tool could be used during initial and further medical training.
This complexity has determined currently functioning division of aging theories into evolutionary and mechanistic.
This complex situation brings along a number of important ethical issues about diagnosis disclosure and end-of-life decisions that need to be addressed.
This complicated interpretation of the other measures of driving performance.
This complicates the ascription of meaning to later life.
This complication can lead to oncologic treatment interruptions as well as diminished quality of life.
This complication has long been recognized and treated with antifibrinolytic medications , including the lysine analog epsilon aminocaproic acid ( EACA ) .
This complication is known as late sequelae of trauma.
This complication renders standard factor replacement therapy ineffective resulting in increased morbidity and mortality.
This compound induced keratinocyte differentiation and fibroblast proliferation by increasing sphingosine-1 phosphate synthesis.
This compound was effective against lymphoma cells with MYC rearrangement from two different patients that were co-cultured with cancer associated fibroblasts.
This compound was first described as the French Paradox in @number@
This computerised battery showed significant heritability of age-related change in cognition.
This concept could be adopted to generate not only teeth but also bioengineered hair follicles , salivary glands , and lacrimal glands.
This concept is appropriate in order to help us to explain individual human behaviours and behaviours in groups.
This concept is recognized in a wide range of product and service settings for its ability to design demand-based products and processes.
This concept may be particularly significant in the evaluation of patients with non-Alzheimer's dementias , such as frontotemporal dementia.
This concept might have relevance for the development of therapies.
This concept provides a background for optimal matching of body size and hemodynamic load on the heart.
This concept provides an important context for nurses working with older adults.
This concerns all their senses and more widely the feeling of being alive and being connected to others.
This concern stems mainly from limited observations in animal models not confirmed in similar studies.
This concise review provides the main examples of neuroprotective activities of the flavones and reveals their potential in prevention and therapyof neurodegenerative diseases.
This conclusion is in line with only some of the previous studies.
This conclusion is in line with several theoretical accounts of age-related differences in cognitive processing and also with emerging evidence from cognitive neuroscience.
This conclusion was not tempered substantially by the cost of vitamin D analogues or oral phosphate binders.
This concurrence , together with absence of precise diagnostic methods , makes diagnosis complex.
This concurs with the notion that PD represents a group of related diseases with a number of potential pathogenic pathways.
This condition disproportionately affects women and its incidence is increasing with the aging United States population.
This condition has been identified in certain agricultural communities , predominantly among male farmworkers.
This condition increases the risk for patients suffering BPPV to have recurrent episodes , even if correctly managed by repositioning maneuvers.
This condition increases the risk of adverse health outcomes as infections , falls , delirium , institutionalization , progression of comorbidities and mortality.
This condition is associated with much comorbidity and with a lower life expectancy.
This condition is characterized by enlargement , close approximation and impingement of one spinous process on another ( \ "kissing spines \ " ) .
This condition is commonly associated with PTT dysfunction or rupture , which can have an arthritic or a traumatic etiology.
This condition is compounded by an ever-growing number of gay men who are aging and living with HIV.
This condition may be termed pathological ageing ( PA ) .
This condition not only results from , but also drives immunosenescence.
This condition will become more common , in both relative and absolute terms , in the coming decades.
This confirmed the expert hypothesis that nurse care coordinators spent most of their time communicating about their patients and managing problems.
This confirmed their greater fractal distance from the healthy value of @number@
This confirms that paraoxonase might play an important role in homocysteine-thiolactone metabolism.
This confirms the notion that a mere arrest in the presence of active MTOR may lead to senescence.
This confirms the primacy of health as the determinant of well-being among the oldest-old.
This conformational change profoundly affects protein activity and is a major method of cellular signaling and regulation.
This connection is informed by actions of natural selection on the determinants of ageing and longevity.
This connectivity change correlated with the TMS effects over brain networks.
This connectivity was reduced in aMCI patients.
This conservative response style may be the result of reduced sensitivity to rewards in apathetic individuals.
This consideration may justify the development of treatments that preserve fertility.
This constant activity signifies that there is no need to form more residents than the number of practitioner to retire.
This consumes very significant health care resources , and so we need to identify new cost-effective methods to aid current diagnostic practice.
This contention is largely confirmed by the study of identical twins raised apart.
This continuous increase in the number of cancer cases will keep its pace in the future.
This contradicts past assumptions in the field and necessitates the development of separate analysis and processing techniques for swallowing sounds and vibrations.
This contrasts , however , with data reporting an inhibitory effect of melatonin on this sirtuin in some tumor cells.
This contrasts with how community dwelling older people and offspring / caregivers conceive future care decisions over time.
This contrasts with the large number of studies which have attempted to categorize gait patterns in children with cerebral palsy.
This contributes to maintain the nicks required for EXO1 entry , and in this manner ensures the dominance of the EXO1-dependent MMR pathway.
This contributes to reduced mobility and impaired quality of life ( QoL ) among seniors.
This contribution aims to provide an overview of experimental works to increase the comprehension and prevention of falls and fall-related injuries in the elderly.
This contribution discusses technologies for acoustic user interaction in ambient-assisted living ( AAL ) scenarios.
This contribution examines the role of nutrition , glycation , and oxidation in skin aging.
This contribution is a reflection on the concept of active ageing from the perspective of relational sociology.
This contribution presents a compressed survey on these subtypes and elucidates their relation to an impaired barrier function.
This contribution reviews the main findings from published epidemiologic studies on contact allergy in elderly populations.
This coordination depends on TOR , and it engages ceramide / sphingolipid signaling.
This coordination requires cross-talk between the tissues , which is mediated by various molecular and mechanical cues.
[ This corrects the article on p. @number@ in vol. @number@ PMID : @number@ ] .
This correlated with other cognitive impairments , particularly in working memory.
This correlates well with its characteristic feature of proximal collateralization.
This correlates with an increase in ERK phosphorylation along with a decrease in protein carbonylation , a marker of oxidative stress.
This correlates with the mixed osteolytic and blastic phase of the disease , the most common phase in the spine.
This correlation disappeared when the characteristics of residents were taken into account.
This correlation has been explained by selection for longevity by social evolution.
This correlation remained significant after adjustment for age , years of education , gender , use of ophthalmic drugs and years of follow-up.
This correlation remained significant even when the influence of aortic pulse wave velocity was partial out ( r = 0.35 ) .
This correlation was more evident in women ( n = 35 ) than in men ( n = 35 ) .
This corresponded to about @percent@ of individual disposable income.
This corresponded with a higher fluorescence on IVIS imaging due to more nanosome binding.
This corresponded with statistically significant reductions in the reflection component of the 2f1-f2 DPOAE.
This corresponded with the ability of postnatal day @number@ but not adult microglia to decrease Aβ immunoreactive plaque load from AD sections in vitro.
This corresponds to a biological age benefit of @number@ years of the offspring as compared to the control subjects.
This corresponds to an overall prevalence of sarcopenia in the elderly rising from @percent@ in @number@ to @percent@ in @number@
This corresponds to improvements of @percent@ and @percent@ from baseline scores of @number@ and @number@ respectively , with higher scores denoting more severe symptoms.
This cortical hyperexcitability is believed to be a compensatory mechanism to execute voluntary movements , despite the progressive impairment of associative cortical areas.
This cost-of-illness study provides a current estimate of the economic burden of male osteoporosis in Germany.
This could aid in prevention and treatment of cardiovascular disease , which affects a significant part of the population.
This could attribute to lowering in immune competence and related necrotic and / or apoptotic manifestations.
This could be a potential risk factor for patient safety.
This could be attributed to retention of native bone , better propioception and shorter operation time.
This could become a growing market.
This could be due to a variety of confounding genetic and lifestyle factors , and in particular to ill-defined and low levels of physical activity.
This could be due to special care offered in these centres , where the medication is more controlled.
This could be explained by impaired degranulation , particularly by mature NK cells of aged mice.
This could be of particular interest in subfertile and infertile women undergoing assisted reproductive techniques ( ART ) in achieving pregnancy.
This could be particularly important for many elderly people with age-related loss of sensorimotor function and a reduced ability to recover balance.
This could be related to the integrated mobilization of physical , cognitive , and social skills promoted by creative dance.
This could be relevant information for health-care decision makers in order to prioritize interventions towards increasing rates of regular dental attendance.
This could be restored by blocking inhibitory pathways and , in particular , by supplementing with IL-12.
This could contribute to a reduced prevalence of allergic disease in the elderly population.
This could contribute to reduced toe flexion force production and may affect the ability of older people to walk safely.
This could contribute to the documented changes in sleep and circadian regulatory processes with aging.
This could explain the discrepancies between studies on vitamin B12 and folate deficiency prevalences.
This could explain the increased width and irregularity of Marx's line in dry eye.
This could have implications for the generalization of the results.
This could help to enhance quality of life for person with dementia and improve quality of care.
This could help to identify preventative measures to be designed and implemented for decreasing the possibility of outbreaks and nosocomial infections.
This could imply that the preimplantation embryo adapts to its in vitro environment with lasting in vivo consequences.
This could indicate that the changed phenotype in aging tendon is not caused by decreased fibroblast function.
This could in turn be partially explained by age-related temporal deficits , as evidenced in the duration production task.
This could in turn lead to shorter telomeres.
This could involve the judicious use of supplements alongside dietary advice.
This could only be realised through an education programme in geriatric dentistry , which should be started without further delay.
This could predispose older persons to corneal stress and development of dry eye syndrome.
This could provide a novel therapeutic target for chronic brain repair in this condition.
This could provide new insights on the pathophysiology of the retinal affection in HbSS / HbSC SC disease.
This could restrict the effectiveness of autologous cell therapy with ADSCs in aged patients.
This could result from a lower body weight and a better functional status that allow to be more active.
This could result in the age-dependent decrease in the level of this hormone leading to aging of the organism.
This counterintuitive attention effect on face processing persisted when scenes replaced letters.
This course offers a promising approach to shifting the paradigm of health professions education to empower graduates to promote quality improvement through team-based care.
This covariation results in individuals acquiring unique sets of traits to establish bone quality.
This created a total of six conditions.
This creates a clinical roadblock to potential therapeutic use in older individuals , who constitute a large percentage of the obesity epidemic.
This creates a growing interest in technologies to enable older people to remain living independently at home.
This creates a major bottleneck in their clinical application , as prolonged expansion is necessary to achieve clinically relevant numbers of cells.
This creates a natural laboratory that scientists can use to understand how policies affect outcomes.
This creates an exciting opportunity to perhaps create novel treatments for AGA , which inhibit the activity of PTGDS , PGD2 or GPR44.
This creates an opportunity to implement cultural competence in the medical curriculum , training of teachers and strengthening the diversity sensitivity of the organisation.
This criterion points the way towards the type of the surgical procedure to be used.
This critical collection of articles demonstrates important theoretical and conceptual frameworks that seek to address the shortcomings of previous models of recruiting diverse populations.
This critical ethnographic study aimed to reveal the ways in which environmental barriers produced and perpetuated disability for @number@ older adults with ARVL.
This critical review discusses the chemistry of these nanomaterials and the context in which their radical scavenging activities have been studied in biological model systems.
This critical review highlights the contributions of chemistry in human telomeres and summarizes the significant development of human telomere biology.
This Critical Review summarizes much of our current understanding of nucleosome assembly and highlights many important insights learned from studying Rtt109 HATs in fungi.
This cross-sectional cohort study describes older patients ' perceptions about depression and characteristics associated with acceptance of treatments.
This cross-sectional field study documented the effect of long-term t'ai chi , meditation , or aerobic exercise training versus a sedentary lifestyle on executive function.
This cross-sectional study aimed to assess the association between mobility and quality of life measures in the near elderly.
This cross-sectional study aimed to provide a detailed account of DS brain morphology and the changes occuring with amyloid neuropathology.
This cross-sectional study examined the association between serum vitamin D and osteosarcopenic obesity in a nationally representative sample of middle-aged and older adults.
This cross-sectional study examined the relationship between age and cognitive functioning in patients with BD.
This cross-sectional study included @number@ individuals between @number@ to @number@ years old who were physically healthy and cognitively intact.
This crosssectional study included @number@ patients recruited in the outpatient geriatric setting.
This cross-sectional study included older adults without cognitive impairment presenting to the Rhode Island Hospital ED from February to @date@ .
This cross-sectional study was based on @number@ Iran retirees ' data.
This cross sectional study was carried out comprising or eight hundred reproductive age ( 15-49 years ) women selected following a multistage sampling procedure.
This cross-sectional study was performed to determine the relationships between CRF and age-related luminal dilation and wall thickening.
This CSPalpha upregulation reached the same level as in young , healthy cerebellum.
This culminates in old mice in an autoimmune syndrome characterized by splenomegaly , plasma cell hyperplasia , and the presence of class-switched , tissue-specific autoantibodies.
This current understanding of the molecular biology of the α-Klotho protein may offer new insights into its function and role in aging.
This cycle can lead to increased cell vulnerability in aging and contribute to an increased susceptibility to degenerative processes.
This cycle of data generation , analysis , sharing , and reuse reveals the vast potential of digital reconstructions in quantitative investigations of neuronal morphology.
This damage occurs in the presence of lipid oxidation but in the absence of any change to protein carbonyl concentration.
This dampening may contribute to preserved affective well-being and reduced affective reactivity to daily stress in old age.
This database included a selection of single images containing the femur and tibia from @number@ subjects with varying levels of osteoarthritis severity.
This database is the most frequently used database in Japanese health-sciences research.
This database will form the foundation for accurate HSA result evaluation.
This database will provide researchers with normative data for Finnish emotion-laden and emotionally neutral words.
This data confirms that although memory processing is poorer in AD , it is sensitive to affective content.
This dataset has @number@ units at individual level that are grouped in @number@ European countries.
This dataset is several times larger than the largest autism study to date.
This data set provides comprehensive information about genes expressed at each stage of differentiation.
This data should be considered in improving cancer treatment selection process for such potentially challenging patients as the elderly NSCLC patients with CVD comorbidities.
This data was compared with published literature on Caucasians to assess the ethnic variations of these parameters.
This data was subsequently used to compare prediction accuracy with both linear and non-linear regression models.
This data will permit clinicians and policy makers to tailor interventions appropriate to the risk class of patients.
This death is mainly caspase-mediated apoptosis.
This debate should not discourage appropriate statin and other lipid-lowering drug administration.
This decay is probably due to a downfall in male fecundity , closely related to a decline in sperm quality.
This decision difficulty effect was most pronounced in 21-year-olds , both in areas associated with task execution and default mode areas.
This decision , which has important consequences for the person , must be based on an objective and rigorous assessment.
This decline can , however , be modulated by the educational level of the sample.
This decline ensued , as peak systolic pressure increase caused by this manoeuvre , was distinctly < 40 mmHg.
This decline impacts on functional capabilities in the elderly and limits their ability to engage in regular physical activity and to maintain independence.
This decline in muscle mass , known as sarcopenia , is frequently observed in postmenopausal women.
This decline is constant and follows an exponential pattern ( slope @number@ to @number@ ) .
This decline is not well understood and it remains unclear if physical decline correlates with the degree of immunosuppression based on CD4 lymphocyte nadir.
This decline may be associated with coinciding development of sarcopenia.
This decline may be due to brain cortico-cortical disconnection caused by age-related white matter deterioration.
This decline was retained even when basic CWIT conditions , processing speed , attrition , gender , and education were controlled.
This decrease disproportionally affects low-frequency clonotypes.
This decrease has been associated with several age related diseases such as falls , osteoporosis , depression , atherosclerosis and sexual disorders.
This decrease in resorption is not observed in the contralateral limb of osteopenic animals.
This decrease is faster for the face compared to both arm sites.
This decrease might be associated with diminished functional autonomy.
This decrease of entropy measures was more evident during REM sleep.
This decrease seems to be linked to sleep alterations in the elderly.
This decrease was demonstrated on a mouse model and on human skin cells in vitro.
This decrease was similar whatever the age , and was slightly higher in females than in males.
This defect is associated with impaired insulin-induced vasodilation and mTORC1 signaling.
This defect of oxidative phosphorylation does not appear to depend on the low amounts of mitochondrial DNA multiple deletions detected in muscle biopsies.
This deficiency is produced by age-related decreases in nutrient absorption , medications that interfere with vitamin B12 absorption , and other comorbidities.
This deficit could be eliminated after additional training.
This deficit may have broader consequences for the effective utilization of predictive cues to guide attention and engender optimal cognitive performance in older individuals.
This deficit was especially pronounced under conditions of retroactive interference that occurred when participants recalled from List @number@ only.
This defines an opportunity to apply knowledge from geriatric population research to people aging with HIV to better appreciate the complexity of their health status.
This definition can be used to advance interventional and non-interventional research of agitation in patients with cognitive impairment.
This definition is accompanied by an equally recent operationalization of SE as a set of capabilities ( @number@ ) .
This definition would encompass preventative approaches aimed at both broad and narrow spectra of age-related pathologies.
This deformity is frequently accompanied by multiple , poorly defined upper eyelid folds and blepharoptosis.
This degeneration of neural pathways disrupts the functional coherence of brain activation.
This deleterious effect is supposed to be mediated by an inefficient recruitment of executive processes during AM retrieval.
This delineation of the role of FoxO6 expands understanding of the pathological and physiological mechanisms of aging.
This demand traditionally has been met with total joint replacements as the definitive treatment.
This demise of somatic stem cell function could contribute to tissue degeneration and organismal aging.
This demographic change has significant impact on health , social , and economic sectors.
This demographic change presents a number of challenges to current research infrastructure aimed at translating discoveries to improved human health.
This demographic shift allows for geriatric research on predictive clinical and biological markers of outcomes related to frailty , re-hospitalization and mortality.
This demographic shift has considerable public health and economic implications since aging is associated with the development of serious chronic diseases.
This demonstrated that our probe could detect caspase-3 in living cells , which confirmed the apoptosis of NSCLC cells.
This demonstrates that human microglia show progressive cell process retraction without cell loss during ageing.
This demonstrates that long-lasting memories are supported by specific patterns of cortical activity that are related to age.
This demonstrates that sequence diversity in humans results from evolving interactions between age , sex , mutation type , and genomic location.
This denaturation product is also observed in the low-power-excitation Raman spectrum of older ambient-air-exposed bloodstains ( @number@ weeks or more ) .
This depended on location in projecting white-matter tracts , and not on infarct size.
This descriptive , cross-sectional and correlational study was conducted with @number@ individuals over the age of @number@ and @number@ caregivers.
This descriptive cross-sectional study included @number@ women aged 40-80 years.
This descriptive study examined the relationship between volunteer activities , depressive symptoms , and feelings of usefulness among older adults using path analysis.
This descriptive study piloted two different approaches to distribute narrative-based HIV educational videos.
This descriptive study surveyed dentists to find out how they would respond to a patient with signs indicating potential CDI.
This detailed analysis detected signatures for purifying selection on regulatory elements as well as coding regions.
This detection method may also prove to be useful for targeted delivery of drugs in the future.
This deterioration is also observed within masticatory muscles.
This development is comparable to the resting state networks found in term-born infants of equivalent age.
This deviation was measured as difference between chronological and the neuroanatomical age ( brain age gap estimation [ BrainAGE ] ) .
This device has not been used previously in a published study to evaluate changes in directionality of forces on facial skin with aging.
This device offers an alternative to selected individuals aged @number@ and over who do not wish to undergo rhytidectomy.
This diagnosis is not confined to the pediatric population.
This dichotomy might explain why only isolated DNA repair pathways are inactivated in cancer cells.
This dictum has not been rigorously tested in clinical practice.
This did not change when a range of health variables were taken into account.
This differed from generalized effects of both agents on task specificity in the encoding phase.
This difference , although statistically significant ( p < @number@ ) , was small.
This difference corresponds to the effect of @number@ years aging on this cognitive domain.
This difference in load-bearing capacity was not statistically significant ( P > @number@ ) .
This difference in mortality was consistent over short- and long-term follow-up ; adjusting for diastolic BP did not change the risk.
This difference in nocturnal urine aMTS6 level between senile cataract patients and controls was not statistically significant ( p = @number@ ) .
This difference is most prominent at the osteochondral junction and likely relates to the presence or absence of ongoing endochondral ossification.
This difference is thought to be attributed to losses in higher cortical systems that are predominantly associated with executive functioning.
This difference may indicate a health disparity based on access to geriatric specialists or mental health care.
This difference persisted after adjusting for multiple covariates.
This difference persisted over time.
This difference turned to be significant in patients above the age of @number@ years old ( p < 0.001 ) .
This difference was also shown for the subgroup of patients in first remission.
This difference was not associated with random measurement error.
This difference was not found in women ( P = @number@ ) .
This difference was not observed between postmenopausal women using HT and premenopausal women.
This difference was not observed in the adults or 10- to 11-year-old children.
This difference was significant at the medial and mid brow ( p < @number@ ) .
This difference was significant ( t = @number@ P < @number@ ) .
This difference was statistically significant at the medial and midbrow positions ( p < @number@ ) .
This difference was still present after controlling for age , height , and weight ( P = @number@ ) .
This differential was not explained by conventional risk factors including age , smoking , social position and body mass index ( BMI ) .
This difficulty may in part , be related to a decline in the neural representation of frequency.
This dilemma necessitates an organized approach to separate patients with mechanical disorders from those with rare systemic disorders.
This direct caregiver workforce is poorly understood , has limited training or standards for minimum education , and training varies widely across provinces.
This disability was rectified by L-dopa administration.
This discovery casts doubt on the validity of PA recommendations found in numerous medical guidelines.
This discovery has allowed the evolution of improved techniques for facial rejuvenation.
This discovery has been one of the most controversial of modern neuroscience.
This discrepancy has led to a crisis that is not easily resolved.
This discrepancy increased with age , indicating an Age × Genotype interaction.
This discrepancy increases with time since injury , suggesting that TBI accelerates the rate of brain atrophy.
This discrepancy is referred to as the \ "in vivo-in vitro paradox \ ".
This discrepancy necessitates a critical reevaluation of the validity of both the trade-off concept as such , and of the current theories of aging.
This disease is clinically characterized by soft tissue fusion of the digits , abnormal craniofacial bone development , small eyes and loss of tooth enamel.
This disease is currently considered as epidemic.
This disease may show various histopathological aspects of the myocardium , but little is known about these in children.
This disease results from mutations in CTC1 , a member of the CTC1-STN1-TEN1 ( CST ) complex critical for telomere replication.
This disorder can , however , affect the person's food intake , widely known as the reverse causality hypothesis of depression.
This disorder focuses on psychological symptoms whereas global studies show that the most prevalent premenstrual symptoms are physical.
This disorder is usually produced by water retention due to the patient's inability to balance water excretion with ingestion of liquids.
This disparity combined with disappointing outcomes of anti-amyloid clinical trials challenges the centrality of Aβ as principal mediator of neurodegeneration.
This display was well received by our expert panel but requires extensive development before testing in a clinical setting.
This dissociation between pathology and dementia increases with increasing age.
This dissociation is consistent with the idea that the hippocampus plays a prominent role in binding information received from distal neocortical regions.
This dissociation is relevant because of recent evidence that has suggested healthy aging compromises the basal ganglia system earlier than the medial temporal lobes.
This dissociation was explored in @number@ younger ( 19-24 years ) and @number@ older ( 65-87 years ) adults.
This distance is then divided by the pulse transit time resulting in the pulse wave velocity.
This distinction was examined in the course of a literature review through the deductive process.
This distinctive test combines teaching organization of the clinical narrative into an assessment tool that promotes acquiring medical knowledge and clinical thinking.
This distinct pattern of age-related changes in selective attention may be linked to the reliance of the visual and auditory modalities on different filtering mechanisms.
This DNAm GA predictor may provide additional information relevant to developmental stage.
This doctrine has been recently challenged.
This document formulates expert opinion guidance for pragmatic managing , monitoring and reversing the anticoagulant effect of DOACs in both chronic and emergency settings.
This document is intended to provide general recommendations for clinicians and to promote the effective use of procedures and medications.
This document presents the Spanish contribution to this map following FUTURAGE guidelines , drawn from the debates held in the ' Ageing.
This does not , however , mean that reactive species ( RS ) and redox signalling are unimportant.
This does not necessarily suggest clinically important differences in thromboembolic potential.
This dogma , however , has been challenged over the past decade.
This down-regulation could be one of the mechanisms causing age-related weakening of synaptic plasticity.
This downregulation resulted in reduced telomerase activity and decreased expression of several telomerase / shelterin genes.
This downregulation was related to the hypermethylation of CpG sequences and specific histone modifications in the gene promoter.
This downward cohort effect largely offset the consequences of an older and larger population aged over @number@
This dramatic change of stature is driven from @number@ major events.
This drug has a residual effect that can allow drug-free intervals , which permit a longer time between schedules.
This \ "drug \ " represents a low , subtherapeutic dose of statin and sartan and particularly their low-dose combination.
This dual role of autophagy in cancers is now getting uncovered by the advancement in the research findings and development of effective autophagy modulators.
This duplication contains an estimated @number@ genes.
This dynamic is referred to as \ "a shrinking kind of life , \ " an in-vivo code built from the participant's own words.
This early immune challenge induces a significant acceleration of aging-related neuropathology.
This easily comprehended knowledge can be used as an important index to assist in public health education and planning.
This editorial discusses aging and the ' asthma microbiome ' separately and then evaluates their potential relationship.
This editorial discusses how cancer metastasis may be better perceived and controlled.
This effect appears , in part , to involve activation of the @number@ AMP-activated protein kinase ( AMPK ) .
This effect appears to reflect the more positive mindset of older people , rather than an intention to regulate emotions associated with personal experiences.
This effect associated with older age was confirmed by propensity score matching ( HR = @number@ @percent@ CI @number@.191-7.558 , p = @number@ ) .
This effect could be antagonized by a selective concentration of the S1R antagonist BD1063.
This effect did not occur for younger listeners.
This effect has only been found in autobiographical memory studies that used participants who were older than @number@ years of age.
This effect is detected after weak radiation , radio-chemical and thermal influences.
This effect is in part by improved the base condition ; however someone of these drugs can modulate platelet targets.
This effect is largely attributed to the exponential increase in chromosome segregation errors in the oocyte with age.
This effect is likely due to the increased conversion of 7KCh to 7KFAEs , which reduced the intracellular 7KCh levels.
This effect is mediated in part by arresting FLT3ITD in an underglycosylated state and thereby attenuating FLT3ITD-driven AKT and ERK signaling.
This effect is moderated by age , with younger participants exhibiting a stronger relation.
This effect is potentially due to the concomitant increase of miR-33b and miR-758 , two well-established regulators of ABCA1 and ABCG1 expression.
This effect is strong enough to overcome the kinase-activating effects of the G2019S mutation in the kinase domain.
This effect is stronger when husbands are the primary earners , and couples are relatively poorer.
This effect is the reason of increasing of various organs function.
This effect may be greater than that of diet or in some cases genetics alone.
This effect might be relevant for the understanding of normal variability in memory function as well as memory-related disorders associated with APOE and BDNF.
This effect of allopregnanolone treatment was identified early in the disease development when AD mice normally have intact memory function.
This effect of butyrate may in part explain the protective action of fibre against CRC.
This effect of feature-based interference was only present in the slow speed condition , indicating that the interference is mainly modulated by perceptual demands.
This effect remained after additional adjustment for physical inactivity , BMI , diabetes , and CVD.
This effect resulted in a \ "healthy obesity \ " phenotype.
This effect was abrogated by inhibition of AMPK but not SIRT1.
This effect was a gradient across the entire 3MS score , extending into the normal range with no apparent threshold.
This effect was comparable for biological and synthetic peptide in both cell types.
This effect was correlated to an age-dependent decrease of p27 expression in IMA from aged CABG patients.
This effect was dramatic in ADD , marked in DLB , and moderate in PDD.
This effect was due to a reduced report of left-ear stimuli , while the report of right-ear stimuli stayed on comparable levels across all ages.
This effect was even more pronounced after stimulation of LPA in combination with testosterone.
This effect was even stronger with slowed-down speech , which gives more time for cognitive processing.
This effect was half the size of the largest covariate effect ( i.e. , age ) .
This effect was higher towards the inner ear space and shifted viable osteocytes into to a centrifugal distribution with age.
This effect was less promiment than that attained with 10-8 M insulin ( @number@ ± @percent@ , p = @number@ ) .
This effect was limited to the period during which the treatment is being applied.
This effect was modified by age suggesting that older adults may under-utilize the PFC in attention-demanding locomotion tasks.
This effect was more prominent in the male FXTAS patients.
This effect was more pronounced the older the participants were.
This effect was more pronounced when healthy male volunteers were treated with the FIASMAs fluoxetine or paroxetine , in contrast to a placebo group.
This effect was not apparent in other hippocampal subfields.
This effect was not due to differences in motor training.
This effect was not found for older speakers.
This effect was not present in men , neither in SNAC-K women aged 60-72 years.
This effect was not significant after controlling for demographics and self-reported physical health.
This effect was only seen in older adults , suggesting magnification of genetic effects on functional brain activity in aging.
This effect was paralleled by an increased engagement of the rostral anterior cingulate cortex , and this frontal engagement was significantly correlated with emotional stability.
This effect was particularly apparent in those with multiple-domain PD-MCI , compared to those with single-domain PD-MCI.
This effect was predominantly in those aged @number@ years and over.
This effect was present for both older and younger adults.
This effect was present for the subgroup with auditory hallucinations , but not the subgroup with visual hallucinations.
This effect was present in both sexes and was not because of fatigue.
This effect was reversed by anacardic acid treatment.
This effect was reversible when the senescence of HPMCs was slowed down by the neutralization of p38 MAPK.
This effect was similar across age groups.
This effect was specific to the experimental task.
This effect was specific to the primacy and middle portions of the serial position curve , where intralist interference and associative demands are especially high.
This effect was stronger in the upper vermilion and medial upper lips.
This effect was strongly mediated by the age of ADHD diagnosis with substantial increases in preschoolers but no corresponding effect in older children.
This element differentially activates α2M expression in senescent versus young fibroblasts.
This elevated complexity complicates the acquisition of relevant information regarding aerobic system dynamics based on pV̇O2 data during a varying exercise stimulus.
This ELISA combined with determination of the IgG4 subclass is useful in screening for anti-NF155 antibodies.
This emergent epidemic represents the next great challenge for biomedical science and public health.
This emerging knowledge is important not only for our understanding of development but may also inform treatments for diseases.
This emerging service requires more research in : enhanced technology design , service delivery models for immigrant caregivers , and evaluation of effectiveness and cost-effectiveness.
This emphasises the need to design rehabilitation interventions that focus on coping , empowerment and self-management for people ageing with LEoP.
This emphasizes the importance of clinical decision-making and weighing up the risks and benefits of treatment.
This empirical study investigates the existence of relational aggression in a sample of residents and the relationship between relational aggression and resident's subjective well-being.
This enabled greater insight into caregivers ' perspective of caregiving complementing our use of Interpretative Phenomenological Analysis ( IPA ) to analyse verbatim transcripts.
This enabled participants to construct strong and agentic personae , and to have the severity of their illness acknowledged.
This enables informative evaluation of anatomical regions outside of the hippocampus.
This enables production of large quantities of the RL fusion proteins in a simple and cost effective manner that is suitable for very large screens.
This enables toxicological observations of individual one-housed rotifers in a closed and controllable micro-environment for up to several weeks.
This endeavor has been supported by the availability of new technological achievements and increasing knowledge about the biology of cell differentiation and cell-cell communication.
This endocrine axis allows regulation of lifespan via metabolism modifications and oxidative stress defense mechanisms.
This end point appears to represent effortful body satisfaction rather than passive contentment.
This enforces the idea that laboratories around the world should obtain their own normative data.
This ensures an individualization of the treatment plan according to the needs of the patient and avoids a postoperative stretched look.
This entity is seen mainly in hospitalized patients with hypothyroidism or syndrome of inappropriate secretion of antidiuretic hormone.
This enzyme also is the replicative primase and replicates DNA with poor fidelity.
This enzyme is ubiquitously expressed , with highest levels in the brain and pancreas.
This epidemiological , cross-sectional study was performed at a family health unit , using a quantitative approach.
This epidemiological review outlines the public health burden of falls and fall-related injuries and the impact of population aging.
This epidemiological study presents utilization of HPC facilities in Berlin with a focus on different immigrant groups.
This epidemiological study shows a clear decline in the daily functioning of older adults with intellectual disabilities over a 3-year follow-up period.
This epigenetic aging signature facilitates age predictions with a mean absolute deviation from chronological age of less than @number@ years.
This epigenetic drift may have deep implications for cellular differentiation and disease development.
This epithelial injury leads to the activation and proliferation of myofibroblasts that secrete extracellular matrix proteins characteristic of fibrosis.
This equates to a @number@ kcal / day lower RMR in a population of completely African ancestry , with one of completely European ancestry.
This equates to a number needed to harm ( NNH ) of @number@ ( @percent@ CI 62-1079 ) for @number@ years of exposure to statins.
This equation is based on patient's hematocrit , plasma urea levels and gender.
This error results from a lack of available measures that can be performed rapidly enough to be incorporated into clinical practice.
This essay critically assesses the understanding of this concept common among biogerontologists , and proposes a new definition.
This essay discusses these problems as seen from the perspective of two practicing physicians in Southeast Asia.
This essay is a reappraisal , on its centennial , of Nascher's landmark work.
This essay proposes drawing on Homi K. Bhabha's concept of colonial mimicry to theorize the young-old's imitation of midlife.
This essay replies to critics since @number@ of my \ "biostatistical theory \ " ( BST ) of health.
This essay will briefly sketch historical changes in the framing of dementia since the late nineteenth century.
This ethnographic study investigates the processes of household disbandment and decision-making of older adults in the Midwestern United States relocating in post-Global Financial Crisis contexts.
This evaluation raised no major safety concerns.
This evaluation should be based on the use of validated and standardized tests.
This evaluation was further substantiated by determination of behavior and neurologic functions and mortality over @number@ h.
This evaluation will determine the patient's frailty status in three categories : robust , pre-frail , and frail.
This event might be accompanied by enhanced cell division within the repopulating pool.
This event promotes ROS production and decreases NO , contributing to endothelial dysfunction under conditions of increased oxidative stress such as aging and ischemia.
This event was associated with enhanced expression of EGFR on the cell surface with concomitant increase in EGF-induced cellular responses in AM251-treated cells.
This ever-increasing trend relates to both women and men and raises many concerns about the risks and consequences lying beneath the natural process of aging.
This evidence comes mainly from studies conducted in the USA and Australia.
This evidence for consistency supports our continued reliance on lay definitions of successful aging.
This evidence implicates medial temporal and frontal regions in schizophrenia.
This evidence indicates that FoxO1 integrates and orchestrates responses to different stress signals to maintain bone cell function and preserve skeletal homeostasis.
This evidence must be considered when using peak VO ( @number@ ) for prognostic stratification and clinical decision-making in patients with HF under b-blocker therapy.
This evidence suggests that attention to optimum health early in life might benefit cognitive health late in life.
This evolution reflects an important characteristic of normal brain development and ageing.
This exaggerated inflammatory response can compromise processes critical for optimal cognitive functioning.
This example might be of use in the response to disease mongering activities from the clinical and public health fields.
This excess risk is more pronounced in the first few years on treatment.
This exercise resulted in increased muscle mass and strength , and increased skeletal muscle protein synthesis and muscle fiber size.
This experiment examined the impact of context expectation on prospective memory ( PM ) performance among older and younger adults.
This expert opinion reports on the published data regarding the efficacy and tolerability of first and multiple injection series of Sinovial®-based product formulations.
This explains the fact that proliferation of the vaginal tissue is mediated by estrogen-receptor alpha and improves the condition for our prolapse surgery.
This exploratory pilot study focuses on older people in a rural Victorian community that regularly experiences hot weather.
This exploratory study examined older rural women's health decision making.
This exploratory study investigates the willingness of nurses and general practitioners ( GPs ) as well as the barriers to undertake antipsychotic discontinuation.
This extended lifespan depends on a functional ER stress sensor protein , Ire1p , and is associated with constitutive activation of upstream UPR signaling.
This extract has shown potent bioactive antioxidant , immunomodulatory and antitumoral properties.
This extreme phenotype likely harbors highly penetrant risk variants , making it primed for discovery of novel risk genes and pathways for AD.
This fact could be explained by the delayed establishment of specific health policies for older adults in Brazil.
This factor should be taken into consideration when performing surgery of atherosclerotic , unruptured aneurysms.
This fact places age as a key factor when mechanical properties of descending aorta are considered.
This fact should be considered when applying BY-VEPs for diagnostics.
This failure has been reported to occur in an estimated @number@ human diseases.
This familial profile suggests that heteroplasmy may contribute to familial longevity.
This family-based model allowed us to monitor possible confounding effects on DNA methylation patterns deriving from genetic and environmental factors.
This FDG-PET study investigates whether metabolic deficits in NL MH are associated with advancing maternal age at birth.
This fear has further increased by the tense rhetoric heard from the recent US presidential campaign and the new presidential administration.
This fear is associated with physical and psychological effects that increase the risk of falling.
This feature extraction process is specific for each kind of disease and is grounded on the findings obtained by medical experts.
This field also is greatly in a more nuanced comprehension about the applicability in clinical practice of trials ' results derived from well-selected HF population.
This field applies the principles of physical sciences , engineering , medicine and the life sciences.
This field creates a myriad of opportunities for improving the health and life of humans.
This field of nutrigenomic research is literally exploding.
This figure is expected to triple in the next @number@ years.
This FI measures the accumulation of clinically evident health-related deficits in mice.
This final adjusted binary logistic regression model was then used to examine the relationship between falls and the independent variables.
This final fate is determined by intricate cellular dosimeters that are yet to be fully understood.
This finding accords with an altered HPA axis and vulnerability to stress-related psychiatric disorders.
This finding also further confirmed that peripheral resolution decreased with age.
This finding coexists with loss of elastic fibers , components known to be essential to the structure and function of the lymphatic system.
This finding confirms the involvement of the temporo-parietal junction in the abnormal body perception during autoscopic phenomena.
This finding could be applied in clinical practice for intervention programs in women with osteopenia and osteoporosis.
This finding could have clinical significance , given that elevated triglyceride is one of the five criterion measures for the diagnosis of the MetS.
This finding demonstrates that a TARDPB mutation can cause early-onset pure FTD without evidence for ALS even in advanced FTD disease stages.
This finding echoes results found elsewhere in the world.
This finding extends evidence of LOC specialization from early childhood into infancy and earlier than developmental trajectories of high-level visual regions.
This finding forms the basis for the current study , presenting as strong evidence for the age-specific differences of the platelet proteome.
This finding generalized across samples examined in this study.
This finding hampers the use of single , or even a subset of characteristics to better understand age-related changes in runners.
This finding has a great potential in the present era of anti-amyloid agents for the treatment of AD.
This finding has implications for efforts to induce beta-cell replication as a treatment for diabetes.
This finding has implications for resource allocation and interventions addressed to improve health and well-being in older adults.
This finding has potentially important implications supporting the view that childhood adversities might have a considerable impact on well being later in life.
This finding helps advance our understanding of how discrimination generates greater disease vulnerability and premature death in African Americans.
This finding highlights the importance of investigating healthcare inequalities also among cognitively impaired older adults.
This finding highlights the need for pharmacological interventions with compounds that stimulate the prosurvival effects of autophagy in the vasculature.
This finding highlights the need to take into consideration population genetic data when dealing with association studies.
This finding , however , neglects potential selection effects into marriage.
This finding implies that the hypertensive state itself possibly worsens arterial stiffness independently from aging in spite of adequate BP maintenance.
This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality.
This finding indicates that infancy is not a critical period beyond which novelty exposure will have little effect on enhancing spatial memory.
This finding indicates that older listeners can exploit their familiarity with a speaker's voice to mitigate the effects of sensory and cognitive decline.
This finding indicates the need for both community and school-based educational programmes as also the implementation of a comprehensive ban on smoking in public places.
This finding is best explained with a facilitation of these consecutive antisaccades.
This finding is consistent with a less stable step pattern during obstacle negotiation walking.
This finding is consistent with bilateral cortical activation being compensatory to maintain performance despite declining computational efficiency in neural networks.
This finding is explained by reference to specific economic incentives arising from national pension legislation.
This finding is important for the understanding of basic mechanisms and sites of neuroplasticity.
This finding is important in understanding the similar problems caused by senescence and other diseases.
This finding is in contrast to the loss-of-function mutations in SMCHD1 that have been associated with facioscapulohumeral muscular dystrophy ( FSHD ) type @number@
This finding is interpreted in terms of preserved top-down control over the allocation of perceptual processing resources in healthy aging.
This finding is logical given that MCI is considered to be the transitional stage between normal aging and AD.
This finding is not in keeping with the idea that physical similarity shapes the mirror-neuron resonance.
This finding is significant given that age is the most established risk factor for development of AMD.
This finding is surprising given the association between the nonamnestic subtype and frontal systems dysfunction.
This finding lends further support to the hypothesis that deranged NO signaling mediates adverse clinical effects of older RBC transfusions.
This finding likely reflects that the intent to remember triggers a specific binding process accomplished by this region.
This finding may be due to the high content of antioxidant compounds including polyphenols.
This finding may indicate a deceleration in the inflammatory component of atherosclerosis with aging in older subjects.
This finding may provide a new neuroscientific approach to understanding individual characteristics of consumers.
This finding might have clinical importance in dealing hormonal disorders in men.
This finding might suggest that an inadequate response of the immune system and oxidative stress may play a role in the pathogenesis of delirium.
This finding might suggest that performance monitoring is more prone to interference by probabilistic information in older adults.
This finding needs to be confirmed by others and evaluated with respect to outcomes of this treatment in institutionalized elderly.
This finding opens opportunities to study potential targets for memory decline prevention in vulnerable populations.
This finding points to the impact of music in childhood and suggests that these results reflect the prevalence of music in the home environment.
This finding potentially provides a mechanism through which the Hippo pathway with its roles in the regulation of centrosome number is linked to the centrosome.
This finding presents salidroside as an attractive agent with potential to retard aging and attenuate age-related diseases in humans.
This finding provides clues that protein accumulation in cellular senescence could be associated with lower miRNA abundance in aging cells.
This finding questions the widespread belief that coretirement is exclusively due to preference for joint retirement shared among spouses.
This finding reinforces the need for thorough assessment of those risk factors in these patients to guarantee the incidence of CVD events remain under control.
This finding should be taken into account in clinical evaluation of visual function of older patients.
This finding should encourage the development of new therapeutic interventions directed at emotion simulation.
This finding suggested the possibility of decreasing frown strength using the disinsertion of the relevant muscles.
This finding suggests a possible role of adiponectin in the age-related decline in Hb level observed in apparently healthy elderly men.
This finding suggests a proteostatic crosstalk between mitochondria and the cytosol , which may play an important role for cell survival during aging.
This finding suggests reliable translation of items from English to Hebrew.
This finding suggests that detailed investigation of autophagy pathways should be undertaken in human hereditary ataxia.
This finding suggests that differences in thyroid function within the population reference range do not influence the risk of CHD.
This finding suggests that DNA sequence composition , not developmental status , is the principal determinant of the human brain DNA methylome.
This finding suggests that older adults are less likely to adjust their encoding strategies to their social expectations than younger adults.
This finding suggests that patients with impaired retrieval are at greater risk for progression to dementia at follow-up.
This finding suggests that the processes which generate different types of adjustment are functionally independent.
This finding suggests that the relationship between muscle strength and muscle mass differs according to sex and age.
This finding suggests that visceral fat may be an important mediator in hormone changes over the menopausal transition.
This finding supports recent concerns regarding the reemergence of social inequality in the retirement process.
This finding supports the dynamical scaling model ( Snapp-Childs and Bingham in Exp Brain Res 198 : 527-533 , @number@ ) .
This finding supports the hypothesis of lower expectations about jobs of disadvantaged groups ( e.g. limited disabled population ) and has important public policy implications.
This finding supports the hypothesis that cognitive disturbances are one of the core non-motor symptoms of ET.
This finding supports the less-wiring-more-firing hypothesis , which provides a testable account of compensatory over-recruitment in OAs.
This finding supports the premise that local dynamic stability is likely a relevant early indicator of falling risk.
This finding surprisingly indicated that patients who had shorter repeats and thereby later onset and potentially better prognoses were at risk for dysphagia-associated problems.
This finding underscores the need for examining past and future mental time travel in relation to aging and life span development.
This finding underscores the value of long-term gait slowing as an early indicator of dementia risk.
This finding warrants further investigation in an independent , similarly powered study.
This finding was consistent across individual studies.
This finding was even more pronounced in patients with higher white matter lesion load. ctDCS revealed no evidence of cortical dysplasticity.
This finding was influenced by age , as older patients exhibited less volume , regardless of gender and edentulism status.
This finding was observed from the early disease stage in all @number@ patients and continued for several months.
This finding was replicated in an African-American sample of @number@ individuals ( lowest P = 9.3 × 10 ( @number@ ) ) .
This finding was validated in the twin cohort.
This first criterion is most important , because it also gives hints for the preferred type of treatment.
This first GWAS meta-analysis for TPOAbs identified five newly associated loci , three of which were also associated with clinical thyroid disease.
This first in vivo study of CMIs in early AD does not confirm findings from autopsy studies.
This five-year follow-up nonrandomized controlled study evaluated community-based training and detraining on body composition and functional ability in older women.
This flavanol warrants its comprehensive evaluation for the treatment of sarcopenia.
This flavonolignan is well-known for its anti-oxidative and neuroprotective properties , among others.
This fly model can thus be used to examine the role of events during adulthood and early AD aetiology.
This focus provides an alternative perspective and approach to addressing skin pathologies and skin ageing.
This force-displacement method may facilitate assessment of small differences between anterior capsulotomy techniques.
This formalization led to extensive opportunities for using the model to analyze reproduction and longevity of living organisms.
This format is effective , easily adapted to local issues , can be delivered using existing infrastructure , and is acceptable to the farm community.
This formulation limits the spread of BoNTA , potentially permitting safe administration of larger doses and possibly extending its duration of action.
This foundational skin knowledge is critical in assessing clients ' aged skin during the aesthetic consultation.
This fraction also inhibited plasmin amidolytic activity ( IC ( @number@ ) = @number@ µg / mL ) and impeded plasmin-mediated proMMP-3 activation.
This framework allows for local adaptation of the protocols and procedures developed in the clinical trials.
This framework assumes that the ONH astrocytes and glia fundamentally support and influence both the lamina cribrosa extracellular matrix and retinal ganglion cell axon physiology.
This framework constitutes an integrated approach to assess functional changes in cortical networks through neuroimaging and peripheral blood markers during early stages of neurodegeneration.
This framework facilitates radiologist to assess breast tissue change and guide them to evaluate individual risk of having breast cancer.
This framework provides BOTH parameters for successful priority setting and proposes means of their verification.
This frequency dependent selection leads towards the strategy maximizing the number of newborns per adult death.
This frequency was similar to that observed in the subjects with the highest Toronto Clinical Neuropathy Score ( @percent@ ) .
This fronto-limbic coupling may represent a vulnerability factor for psychiatric disorders starting in adolescence but not in adulthood.
This function allows better estimation of the maximum human lifespan by providing a good description of the mortality curves in very old age.
This function is implemented , according to the telomere theory , through mechanisms that operate through the system.
This function may be associated with TRIM32-mediated tumor suppressive mechanism.
This further strengthens the relationship between autonomic dysfunction and cognitive disorders.
This further supported the existence of a specific cognitive strategy among top-level rugby players.
This G4 structure can be efficiently stabilized by small molecules with the consequent inhibition of vegfr-2 expression.
This \ "gain-of-function \ " has been linked to the UNE-S domain added to vertebrate SerRS during evolution.
This game has provided the staff members with a better understanding of the issues patients experience as they deal with declines in health.
This gap may significantly affect the success of vascular surgery as a specialty.
This gene encodes a key protein of cell response to DNA damage an ATM protein kinase.
This gene is also termed BTG4 or PC3B.
This gene-nutrient interaction , which appears to be limited to women , warrants further examination in randomized controlled trials of vitamin D supplementation.
This general effect of syntactic complexity on perceptual report accuracy was further exacerbated by age and hearing loss.
This general lack of knowledge of pathogenesis prevents us from reducing the worldwide burden of these diseases.
This general method holds great potential for application to the elucidation of biological mechanisms and their key components in other complex systems.
This generated a list of @number@ proteins that were differentially expressed in different age groups ( young , intermediate , and old age ) .
This generates the prediction that variance in telomere length decreases with age.
This generation had started its medical profession before the significant progressive changes in the medicine occurred in the last decades.
This genetic approach validates the anticancer potential of the MCT1 and MCT4 inhibitors in current development.
This genus of viruses is prevalent globally , and can infect patients across a wide age range.
This global ageing phenomenon will have a major impact on health-care systems worldwide due to increased morbidity and greater needs for hospitalization / institutionalization.
This global effect can be noted @number@ month after treatment and becomes most clinically apparent @number@ months after treatment.
This greater difference in overall change in the angular momentum in women may explain their increased risk of fall over the stairs.
This greater use may be reflective of a combination of higher disability rates , cultural factors , and greater access to AT.
This group certainly includes elderly patients with chronic kidney disease , the management of which has significant effects on health care settings.
This group did not demonstrate practice effects in any other domain and showed a downward trajectory in all domains at each evaluation.
This group difference remained significant for severe ( @percent@ ) compared with mild ( @percent@ ) hallucinations.
This group experiences more illness , disability , and dependency than young adults and consumes the majority of heath care resources.
This group had a higher prevalence of OH at all time-points , and scored lower in tests across all cognitive domains.
This group had good general knowledge but poorer knowledge in areas such as the protection offered by condoms and potential transmission modes for specific STIs.
This group is especially vulnerable to experiencing negative consequences related to homelessness.
This group is known as the young elderly.
This group is rapidly growing worldwide and yet there are gaps in the knowledge related to their health condition.
This group may suffer more often from multimorbidity , because of ID-related physical health conditions , unhealthy lifestyle and metabolic effects of antipsychotic drug use.
This growing burden requires targeted cancer prevention and treatment strategies.
This growing population threatens to overwhelm the current U.S. health care system , which lacks established clinical models for managing their care.
This guideline shall help physicians to advise and treat patients exposed indoors to mold.
This GWAS was enhanced using a tissue-specific protein-protein interaction network approach.
This had a significant influence in regression models of bone Pb and thus we recommend that uncertainty be considered in future studies.
This has a definite impact on health professionals who have to assess their competency to live independently and manage their finances.
This has also changed the risk pattern of plasma-extracted products , especially in terms of continual reduction of viral transmission.
This has been assigned to the known bioenergetic , anti-apoptotic , anti-excitotoxic and anti-oxidant properties of creatine.
This has been associated , at least in part , with defective cellular signaling via protein kinase C ( PKC ) signal transduction pathways.
This has been common knowledge since time immemorial.
This has been confirmed by a significantly reduced expression of the same molecules in cells of subgrouped elderly versus younger individuals.
This has been consistently associated with a decline of the ability to coordinate the performance of two tasks concurrently.
This has been spurred on by the accumulation of the evidence for benefits of the multidisciplinary team model of comprehensive geriatric assessment and management.
This has been the center of the a-integrative theory of aging demonstrating an attitude to life based on cognitive and emotional dimensions.
This has emerged as a major obstacle for their application for late-onset diseases.
This has far-reaching implications , considering that variants like p.Glu984 identified by preconception screening ( 'Kingsmore panel' ) do not necessarily indicate JBTS carriership.
This has given rise to the situation Tithonus faced in Greek mythology of living longer but not staying young.
This has greatly limited the application of HRT in anti-aging therapy.
This has great potential for aiding diagnosis and patient stratification as well as for monitoring disease progression and treatment response.
This has highlighted the importance of cortical porosity in describing possible sex differences in fracture risk.
This has implications for clinical management of patients with multimorbidity as well as risk adjustment for database studies.
This has implications for computerized training tasks where automated feedback is considered crucial.
This has implications for inclusive design of many everyday products.
This has implications for longitudinal studies which want to study age-related decline in chair rise performance.
This has implications for testing and diagnosis , treatment , population health and personal hygiene practices.
This has implications for the definition of MCI , as lack of functional impairment is generally used as a criterion for diagnosis.
This has implications for the preoperative , intraoperative and postoperative management of elderly patients scheduled for thoracic surgery.
This has implications for understanding the role of oxidant burden in pre-clinical vascular dysfunction.
This has implications in hypertensive treatment where there are marked changes in arterial stiffness , as occurs with aging.
This has important consequences for medicine.
This has important implications for clinical trials targeted to modify AD biomarkers.
This has important implications for neuropsychological testing of older populations who have a high prevalence of cataract.
This has important implications for the provision and funding of care home places and community services.
This has induced various types of responses by physicians.
This has informed the identification of new potential targets and approaches to treatment.
This has initiated a process to harmonize the use of diagnostic criteria and the MMSE including administration guide.
This has led some to characterize COPD as an \ "accelerated aging phenotype. \ "
This has led to an enhanced focus on issues related to aging and age-related diseases.
This has led to an increased utilization of advanced clinical practitioners ( ACPs ) .
This has led to attempts to develop telomere-elongating treatment.
This has led to debate , along with the suggestion to use absolute concentrations of fatty acids.
This has led to difficulties in accurately delineating the burden of disease , exploring geographic differences , and recruiting appropriate subjects to clinical trials.
This has led to greatly increased response rates and durations of response , as well as improved survival.
This has led to the theory of age-specific anatomic abnormalities in autism.
This has many potential implications in a group of predominantly elderly patients with altered pharmacokinetics , comorbidities and polypharmacy of potentially toxic drugs.
This has not been noted in previous reports of bladder tamponade in Japan.
This has opened up an entirely new field of experimental research aiming to elucidate genetic interactions and screen for modifiers of disease processes in vivo.
This has permanent effects on cellular ageing such as regulation of telomere length.
This has permitted an analysis of the color-aging behavior of those displays over that time.
This has potential for retrospectively identifying delirium in cohort studies where routine medical records are available.
This has protean implications for the future of our specialty and public health in the United States.
This has proven intractable to modelling appropriately in model organisms.
This has raised concern about the potential harmful effect of high folic acid intake and UMFA on health conditions such as cognitive dysfunction and cancer.
This has raised several questions regarding the ability of regular endurance training to preserve functional capacity with age.
This has resulted in a lack of evidence that has complicated treatment in this patient group.
This has resulted in a sex-related CVD mortality gap , with women having higher mortality than men since @number@
This has seen older adults ' concerns about appearance and body image somewhat sidelined in practice and in research.
This has stimulated interest in the preventive potential of antioxidant supplements.
This has suggested decreased motor lateralization and functional compensation within the aging brain.
This has turned out to be more difficult than at first expected.
This held true for both ears , even when age was accounted for.
This helps to explain the hearing-in-noise difficulties often seen in the aging and hearing impaired population.
This helps to identify requirements for IPE to optimize care of people with dementia and to support informal caregivers in the future.
This heterogeneity also may explain why most therapeutic interventions have not improved survival.
This heterogeneity disappears in the group of very old participants for each class.
This heterogeneity may be a contributor to the lack of reproducibility in association studies to date.
This higher ratio reflects a distinct metabolic phenotype of prostate cancer cells consistent with previously reported alterations in the energy metabolism of these cells.
This highlights the benefit of automated QS detection for exploring brain maturation.
This highlights the importance of routine monitoring of anabolic hormone profiles to sustain and optimize health and readiness in chronically stressed populations.
This highlights the importance of widespread assessment of health , including functional vision , to prevent balance impairment and maintain independent mobility among older population.
This highlights the more robust ability of PBB3 to capture wide-range tau pathologies.
This highlights the need for public health initiatives to reduce alcohol consumption in older people.
This highlights the need for training GPs in the conduct of cognitive screening before such procedures can be implemented on a routine basis.
TH is highly regulated , notably by phosphorylation of several Ser / Thr residues in the N-terminal tail.
This high resolution study extends available population-based survival data of breast cancer patients.
This hippocampal dependency of memory recall progressively decays with time , a process that is associated with a gradual increase in dependency upon cortical structures.
This histopathologic finding parallels an age-related autonomous aldosteronism and abnormal aldosterone physiology that provides @number@ potential explanation for age-related cardiovascular risk.
This historical overview will be informative for other developing countries in resolving their own public health problems.
This historic case series analyses @number@ patients treated in this state from @number@ to @number@
This holds true despite of aging , brain damage or visuospatial disorders.
This holds true for geriatric psychiatric patients as well.
This holistic approach will maximize the exciting opportunities for these and related chemical technologies in the study and discovery of novel biology of metals.
This homeostasis is disturbed by age-associated , minute alterations in aortic hemodynamic and mechanical properties that induce short- and long-term alterations in each other.
This Hot Topics review will cover important new findings in this area that have occurred over the past year.
This , however , brings new challenges that need to be addressed at the primary health care level.
This HPLC method is a sensitive and reproducible way to detect menadione in urine.
This hybrid strategy was hypothesized to stem from developmental changes occurring in the integration of sensory information around @number@ years of age.
This hyperaroused state is unique and is a severely disabling feature of PSP.
This hypolipidemia can be found without a decrease in the serum levels of other energy sources , such as glucose , in the presymptomatic stage.
This hypometabolic state is manifested by lowered neuronal glucose uptake , metabolic shift in the astrocytes , and alternations in mitochondrial tricarboxylic acid cycle function.
This hypothesis accounts for the mechanism of insulin resistance in obesity , type @number@ diabetes , aging and lipodystrophy.
This hypothesis can bridge the gap between existing theories and the empirical findings on age-related changes.
This hypothesis-generating investigation may help design future studies to explore these complex relationships in greater depth.
This hypothesis has implications for the evolution of a wide array of human features.
This hypothesis has no previous documentation in scientific media and has no protocol.
This hypothesis has not been extensively explored in sepsis and bacterial infections.
This hypothesis is often tested with a \ "diathesis-stress \ " model , in which genes confer excess vulnerability.
This hypothesis is referred to as \ "the double neurogenic niche hypothesis. \ "
This hypothesis may have a very negative content at the first sense.
This hypothesis poses a question : what is the mechanism of the biological clock that controls aging ?
This hypothesis predicts that attenuating microglial activation may provide benefit against disease.
This hypothesis remains to be tested.
This hypothesis should be tested in randomized controlled trials.
This hypothesis suggests that the exogenous base-alkylating agent , methyl methanesulfonate ( MMS ) , would further increase mtDNA mutagenesis.
This hypothesis was supported by the results from the in silico analyses , predicted a major kink on this helix.
This hypothesis was tested by measuring inhibition of human acetyl- and butyrylcholinesterase by two commercial DSM solutions.
This hypothesis was tested using aortas of normotensive ( WKY ) and hypertensive rats ( SHR ) , along with human mammary artery.
This hypothesis will be checked in future clinical studies.
This ICR then develops increased DNA methylation.
This idea fits with the authors ' understanding of biology in older organisms.
This identifiability effect occurs in children and adults , showing that identifiable novels are processed differently from non-identifiable novels in both age groups.
This identified two mutants with autosomal recessive forms of EC , and reduced lifespan , designated Ecalc1 and Ecalc2.
This identifies an important intrinsic step in replicative aging.
This illness along with its treatment has a great impact on a woman's subjective opinion of her quality of life and functioning in everyday life.
This illustrates the existence of a widespread early exit culture among senior teachers in Flanders.
This imbalance , called oxidative stress , leads to the progressive damage of cellular structures and results in accelerated aging.
This imbalance is expected to worsen , as the aging population requires more health care resources.
This imbalance leads to damage of important biomolecules and organs with potential impact on the whole organism.
This imbalance may predispose to thrombosis by enhancing platelet and clotting activation and eliciting endothelial dysfunction.
This immobility is often compounded by a fear of falling , which further immobilises patients and affects their quality of life and physical performance.
This immune ageing occurs without previous CMV infection.
This immune dysregulation may affect conditions associated with chronic inflammation , such as atherosclerosis and Alzheimer's disease.
This impact could be because of chronic overactivation of the body's physiological stress systems.
This impact of interference on working memory is exacerbated with normal aging.
This impaired brain vasculature correlates with the onset of dementia , a symptom associated with hippocampal degeneration seen in both diseases.
This impaired ECFC angiogenic potential was not associated with a quantitative modification of the circulating endothelial compartment.
This impaired insulin signaling might be a possible link between AD and DM.
This impaired speech perception may , in part , be due to desynchronization affecting the neural representation of acoustic features.
This impairment correlated with elevated nighttime cortisol levels , indicating a potential worsening impact of caregiver burden on age-related cognitive decline.
This impairment should be considered during motor control evaluation in older populations , whether it be activities of daily living or skill assessment.
This impairment was characterized by diminished CBF changes in response to normal or even increased NO signals and associated with markers of nitroxidative stress.
This imperative often required long hours away from the family.
This imperative often required long hours away from the family.
This implies a careful evaluation of thyroid nodules in this group of patients in order to exclude malignancy.
This implies a faster age-related reduction in , but not absolute level of serum total testosterone as a risk factor for PCa.
This implies an increasing need of medical care after age @number@ whereas social care , including institutionalization , becomes a necessity only in nonagenarians.
This implies disentangling effects of hearing impairment versus age and examining the interplay between both factors in different background noises of everyday settings.
This implies significant consequences with regard to the development of weight loss , anorexia , social disadvantages and increased mortality with serious socio-economic burden.
This implies that cofilin and drebrin can either overcome or reverse the allosteric changes in F-actin induced by the competitor's binding.
This implies that most behavioral , physiological and biochemical variables display circadian rhythms in their expression.
This implies that neurons affected by AD can still be reactivated if the right stimuli are applied.
This implies that preventive strategies for MCI may need to begin in midlife and should persist throughout late life.
This implies that SETD8 may be part of a cell proliferation checkpoint mechanism and has important implications in antitumor therapeutics.
This implies that signs of brain atrophy develop before the current conventional definition of \ "preclinical AD \ ".
This implies the integration of egocentric and allocentric reference frames , of visual and idiothetic cues , and access to long-term memory.
This important property makes UCPs an ancient partner in the metabolic adaptation of cancer cells.
This improvement disappeared in the 24-hr and the 1-week delay conditions.
This improvement is related to the improvements in the LVEF and functional capacity. .
This improvement was nevertheless lower in smokers than the non-smokers , confirming the negative impact of smoking on periodontal regeneration.
This improvement was not observed with HAs.
This improvement was significantly ( p = @number@ ) greater in the middle-aged compared with the younger WBVT group.
This improves outcomes , decreases healing time , and mitigates comorbidities.
This inability to compensate leads to increased rates of postoperative complications and death.
This incidence pattern suggests the presence of separate early-onset and late-onset PTLD subtypes.
This included general approaches for a variety of symptoms as well as symptom-specific interventions.
This included genes involved in cartilage homeostasis and survival , as well as genes with potential importance in the pathogenesis of OA.
This includes brain atrophy , beta amyloid deposition , cognitive decline , and Alzheimer's disease-factors indicative of brain aging.
This includes cognitive processes essential for motor performance.
This includes communication between organelles , which allows them to function and adapt to changing cellular environments.
This includes heart failure nurse coordination based in the cardiac team , palliative care and general practice support.
This includes more than @number@ million persons of racial / ethnic minorities ( African American , Hispanic , and other ) .
This includes polar segregation of damaged proteins and ERCs due to the septin-based diffusion barrier , asymmetric inheritance of MDR proteins and retrograde protein transport.
This includes restricting the development of neuroinflammatory activation , providing neurotrophic support to neurons , and providing neuroprotection against oxidative stress.
This includes simultaneous lower blepharoplasties and video-assisted transtemporal subperiosteal and sub-SMAS tissue release.
This includes the heart , lung , brain , bone and connective tissues.
This includes underserved farmers who are at risk of not receiving the appropriate services due to limited resources and lack of awareness.
This increased alertness for nutritional problems has a lot to offer in the willingness for early intervention.
This increased CoG acceleration was associated with an increased anticipatory peak of ML centre-of-pressure shift towards the swing-leg in young adults only.
This increased DNA methylation may be a significant contributor to the neuropathology and psychopathology underlying the risk of suicide in depression.
This increased effectiveness of highly fluctuating forward maskers was similar for older adults with normal and impaired hearing.
This increased metastasis correlated with genomic instability and aneuploidy in tumor cells from G5 Terc- / - mice.
This increased serotonin function may result in further dysregulation of thalamocortical signals and so promote the expression of dyskinesias.
This increased susceptibility may be responsible for the rapid disappearance of a considerable fraction of the RBCs during the first @number@ hours after transfusion.
This increased vulnerability state results from dysregulation of multiple physiological systems and its complex interactions.
This increase has brought a concomitant increase in morbidity and mortality from other conditions related to the adverse effects of cancer treatments.
This increase in energy intake is not necessarily offset by an increase in activity , rather an increase in sedentary behaviours.
This increase in hydrophobicity most likely aids in the sequestering of A2E into granules with the concomitant diminution of its reactivity.
This increase in protein synthesis was seen in both young and old men , with no differences between age groups.
This increase in recall variability with age was strongest under conditions of greater memory load.
This increase in the elderly population has prompted interest in recent years toward the study of frail older adults.
This increase in TH homo-specific activity suggests activation by increased phosphorylation at the N-terminus of the TH protein for a compensatory increase in DA synthesis.
This increase is combined with high antibiotic consumption.
This increase is commonly attributed to insufficient sleep durations resulting from increasingly limited time in bed.
This increase is comparable to protein provided by one standard portion of ONS.
This increase is difficult to detect in cross-sectional analyses of the population-level mean.
This increase is not explained by demographic or cardiovascular risk factors or by prestroke cognitive decline.
This increase may lead to the preservation of matrix integrity and thereby contribute to the firmness of skin.
This increase might represent a protective mechanism towards acute insults in aging subjects.
This increase might represent the consequence of perineurial collagen type IV deposition with aging.
This increase occurs in all age groups , but depends mainly on the basal concentrations of TSH and FT4.
This increase of NF-κB -associated transcription includes transcripts for pro-inflammatory cytokines such as IL-1 and chemokines such as CCL2 and CXCL10.
This increase raises questions about how the workforce can meet the challenge of providing quality care.
This increase reflects aging and obesity in keeping with more developed countries like Australia , India , Thailand and the United States of America.
This increases the likelihood of inappropriate medical practices and an evidence-practice gap.
This increases the relevance of maintaining usual physical performance of patients even during hospitalization.
This increase was associated with immunohistochemical findings of cells expressing markers characteristic of progenitor-like cells.
This increase was blocked by sgp130.
This increase was dose-dependently and significantly blunted by baicalein.
This increase was due to a growth in population and increase in aging.
This increase was exaggerated ∼3-fold in recuperated offspring.
This increase was maintained at the next follow-up appointment ( p < @number@ ) .
This increase was most striking in middle age , and greater in females than in males from @number@ years up to @number@ years.
This increase will tax healthcare systems , which are already showing the limitations of the present model of follow-up.
This increasing demand requires more residential aged care facilities and healthcare workforce.
This increasing probability of late survival comes with considerable individual , economic and social impact.
This index could guide policy and interventions to enhance resources in vulnerable subgroups and diminish inequalities in successful aging outcomes.
This index is based on the ensemble empirical mode decomposition method.
This index rapidly increased thereafter , reaching a peak at @number@ years , then gradually decreased.
This index reflects the subject's level of pathology and position along the AD continuum.
This index was significantly higher in the young group.
This indicates a difference of @number@ g in birthweight of newborns for media with an age difference of @number@ days.
This indicates a higher susceptibility to develop inflammatory diseases with increasing age.
This indicates an importance of mechanical loading for maintenance of tendon collagen turnover.
This indicates a widespread and long-lasting bivalency effect , replicating previous findings.
This indicates significant interpopulation differences in the relationship between the Calce acetabular variables and age , even between populations of European ancestry.
This indicates that a cognitively active lifestyle may protect against cognitive decline or delay the onset of dementia.
This indicates that activated microglia appear in several cortical and subcortical areas during healthy aging , suggesting widespread neuronal loss.
This indicates that changes in constituents of the meibum spectra ( eigenvectors ) were due to age-related compositional differences.
This indicates that children cannot inhibit processing of meaningful task-irrelevant information as efficiently as adults.
This indicates that curcumin in this novel drug delivery system is an excellent candidate for periodontal disease treatment.
This indicates that democratic voting can be systematically adjusted by activating innate biases.
This indicates that fast movements cause different influences on dynamic postural control in elderly people , particularly from the point of view of muscle activation.
This indicates that gaze anchoring to pointing completion is not a prerequisite for the production of subsequent pointing.
This indicates that GSTP1-1's TRAF2-binding region involves the GSH-binding site.
This indicates that higher per-enrollee HCBS spending may enable waiver enrollees to remain in the community until their functional impairment becomes more severe.
This indicates that incongruence of the scene may be particularly disturbing in late adulthood , therefore impairing object recognition.
This indicates that increased oxidative stress and markedly enhanced erythropoiesis in β-thalassemia / HbE patients leads to accelerated telomere erosion in clinically severe patients.
This indicates that , in later life , some forms of class-related health lifestyles become fixed or ' locked in'.
This indicates that interlimb coordination and gait stability may be distinct features of locomotion.
This indicates that patients with pure alexia rely heavily on intact top-down information , supporting the interactive activation model of reading.
This indicates that the acute anabolic potential to conventional feeding is maintained in non-cachectic early stage breast cancer after major surgery.
This indicates that the exponential increase ( curvilinear performance ) of correctly learned words does not solely depend on semantic and / or length features.
This indicates that the increased OPG / RANKL ratio can reduce the osteoclastogenesis of RAW264.7 cells.
This indicates that utilizing linguistic ability to improve speech perception is associated with increased listening load.
This indicates that while females undergo slower involution than males , they ultimately attain similar phenotypes.
This indicates the need for dental associations to provide such training throughout Japan.
This indicates the need for selection of safer drug therapy alternatives in this patient group.
This indicates the relevance of declining cognitive abilities in the ability of older persons to recognize speech in noisy environments.
This indicates the usage of alternative metabolic pathways that provide survival in extreme conditions.
This individualized approach holds great promise for improving the safety of HT.
This inferior visual hemifield advantage emerged early in life and persisted throughout aging.
This inflammatory microenvironment can stimulate the proliferation of epithelial cells containing DNA mutations which can ultimately lead to cancer.
This inflammatory profile correlated with the levels of phosphorylated STAT3 proteins in monocytes but not with the serological response to the vaccine.
This inflammatory response and increased morbidity with age was independent of T cells or NK cells.
This inflammatory response plays an important role in the development of cholestatic liver injury in this and other cholestatic conditions.
This inflection in risky choice behavior has been attributed to a neurobiological imbalance between earlier developing motivational systems and later developing top-down control regions.
This inflexibility in the aged epigenome may lead to an age-related decline in phenotypic plasticity at the cellular and molecular levels due to epigenetic drift.
This influences on the appearance of psychotic symptoms in the elderly.
This influx is reduced on pharmacological inhibition of voltage-operated Ca2 + channels.
This influx was not changed by SME liposomes compared with the untreated control.
This information can be used for the characterization and monitoring of the physiological adaptations induced by endurance training.
This information can be used to identify dysfunction in age-related macular degeneration and glaucoma.
This information can be valuable to help promoting organic meats to the consumers.
This information combined with an illustrative case example is presented.
This information could be used to construct an owner-based questionnaire to assess feline DJD-associated pain.
This information could optimize pharmacotherapy.
This information is beneficial when creating interventions and exploring diet-health relationships.
This information is essential for developing new strategies to control the intraoral wound-healing processes of the individual patient.
This information is of national importance because of the aging infrastructure of American cities and the likelihood of similar problems in other locations.
This information is stored and subsequently analyzed to determine sleep and wake periods by epoch.
This information is summarized in a model describing how CR and low T ( b ) , both synergistically and independently , increase lifespan.
This information is then used to improve the initial V segment assignments from existing tools , like IMGT / HighV-QUEST.
This information may assist in counseling patients regarding efficacy of sling procedures and in setting expectations for women at increased odds for treatment failure.
This information may facilitate the design of early interventions to prevent disease progression.
This information may help to understand RBC homeostasis and the effects of transfusion , especially in immunologically compromised patients.
This information may open a gateway for connecting seniors to social and economic resources that will support them in remaining productive and healthy.
This information should be a priority for future publications.
This information was used to derive a general cognitive factor.
This information will be helpful to hypothesize and ultimately understand how ARHL may be mechanistically related to changes in brain structure and function.
This information would be of interest for producers , sellers , and inspection agencies.
This inhibitory effect is caused by the slower rate of hydrolysis due to possible small enzyme structural changes.
This inhibitory effects of PLE on MMP-1 and MMP-3 were mediated by reduction of ROS generation and AP-1 DNA binding activity induced by UV.
This in itself poses a great challenge.
This injury appears to be amenable to treatment.
This input from @percent@ of the dataset was used to train a classifier against the tweet text and code the remaining @percent@ of the dataset.
This instrument is significant to professional practice as practitioners working with older adults will be better equipped to assess for risk of mistreatment.
This integrated characterization combined with mutational data opens new opportunities for therapeutic strategies.
This integrates the implant with the host bone which stabilizes the implant position and shape initially and in long term.
This integrative database is freely available on the web at @url@ .
This integrin-β1 N-glycosylation pattern was correlated with higher levels of membrane-bound integrin-β1 and also with increased binding to fibronectin.
This interaction between knowledge and fluency extends dual-process theories of aging.
This interaction is fine-tuned by neurohumoral activity , including atrial natriuretic peptides , renin-angiotensin aldosterone system and sympathetic activity.
This interaction remained significant after controlling for other physical activity , demographics , and health variables.
This interaction requires 12-24 h of nutrient restriction and is dependent on protein synthesis.
This interaction was found for processing speed , the cognitive domain most impaired in our patients.
This interaction was not significant for men in either sample.
This interdisciplinary dialogue would facilitate a process of self-reflection within biomedicine.
This interesting pathogenetic constellation targets the RB and p53 tumor suppressor pathways in tandem , while simultaneously activating oncogenic Wnt signaling.
This interference effect did not vary with participant age , contrary to the hypothesis that older adults are more susceptible to semantic interference.
This internationally important study has the potential to inform research into cognitive ageing in the future , and offers an excellent resource for collaborative work.
This internship in care of the elderly should become an obligatory course at all @number@ medical schools in the Netherlands.
This interplay between extracellular and cellular compartments could hasten mammalian aging and the progression of aging-related diseases.
This interplay of both intrinsic and extrinsic factors makes a generalization on trends for contact dermatitis in older adults challenging.
This intervention applies a one-group pre- and post-test design to improve diabetes knowledge.
This intervention is similar to the regular activities of many faculty members in the humanities.
This intervention study was a prospective , non-controlled trial with @number@ PU patients.
This interview study explores the experiences of @number@ Australian grandfathers.
This interview study explores the experiences of @number@ Australian grandfathers.
This intracellular calcium increase stimulates the migration and exocytosis of the insulin granules.
This introduction begins with memories of homophobia the editors experienced to remind the reader of the general climate old lesbians faced in their younger years.
This introduction serves to foreground current patterns associated with HIV and aging , globally.
This in turn activates protective mechanisms which counteract cardiotoxic stress and promote survival in states of experimental cardiomyopathy.
This , in turn , causes polymer degradation and results in decreased resin-dentin bond strength over time.
This , in turn , implies that geriatrics does not start in the elderly or with the onset of particular geriatric disorders.
This , in turn , increases tau phosphorylation at disease associated Ser396 , Ser404 , and Ser202 sites , and impairs neural viability.
This in turn increases the severity of expiratory airflow limitation and induces dynamic lung hyperinflation during exercise.
This , in turn , influences cell energy metabolism.
This in turn is important for understanding the repair processes after such damage occurs.
This , in turn , leads to oxidative modification of the key plasma protein , apolipoprotein A1 ( ApoA1 ) .
This in turn led to abnormal mitochondrial membrane potential , respiratory chain activity and morphology.
This in turn makes additional damage more likely.
This , in turn , may even stabilize the numbers and genetic compositions of the age groups.
This , in turn , may increase risk of falling.
This in turn requires robust and reliable systems for performing 3D in vitro culture of neural lineage cells.
This in turn suggests early reflex control and proprioceptive demands in learning and maturation of jaw motor skills.
This , in turn , suggests the importance , for older adults , of maintaining habit-related spatial arrangements.
This , in turn , would lead to improvement in the ability to immediately imitate non-native speech.
This inverse relationship is not seen in older men.
This investigation aimed to explicate this relationship , and hypothesized it would be mediated by executive functioning ( EF ) .
This investigation compared the neural correlates of inhibition in normal older adults ( OAs ) and OAs with mild cognitive impairment ( MCI ) .
This investigation contributes to our understanding of age-related differences in source memory processing in middle childhood.
This investigation delineates aortic geometry across the adult age spectrum and determines the gender-related influence of aging on aortic morphometry.
This investigation demonstrates that the rhytidectomy technique is safe and produces highly predictable results.
This investigation examined the influences of changes in intellectual , social , and physical activities between waves on four dimensions of depressive symptoms at follow-up.
This investigation examines the association of ESR1 ( PvuII and XbaI ) and CYP19 ( rs4646 ) polymorphisms with longevity.
This investigation explored how nurses were impacted by the disasters and how they can best be supported in their nursing responsibilities.
This investigation identified male sex , age , and tobacco exposure as independent risk factors for OS.
This investigation involved a two group design ( control vs. assessment ) .
This investigation sought to understand the net impact of local adipocytes on skeletal myocyte metabolism.
This investigation was to further clarify the effects of different menstrual phases on cardiac autonomic nervous activity disturbed by SD.
This in vitro method allows investigation of the molecular mechanisms pertaining to how CR influences aging processes leading to life extension in human cellular systems.
This in vitro study compared the marginal adaptation of all-ceramic MOD-inlays luted to human molars with four self-adhesive resin cements.
This in vitro study evaluated the marginal adaptation of etch-and-rinse adhesives.
This in vivo imaging method can show modifications at the cellular level induced by anti-glaucoma drugs on ocular surface structures and adnexa in the eye.
This in vivo kinetic evidence will uncover the underlying mechanism for uremic dyslipidemia and provide strategies to reduce CVD in HD patients.
This involves surface and intracellular cell staining coupled to fluorescence in situ hybridization to detect telomeres ( flow-FISH ) .
This IQ change was not found in the nonsurgical comparison group.
This is a case study of an 88-year-old man who presented with agenesis of the corpus callosum and colpocephaly.
This is a case that will arise frequently in genome-wide mediation studies.
This is accompanied by a 2-fold augmented ADAM10 amount as compared with nontransgenic littermates ( P = 0.011 ) .
This is accompanied by an overall extension of lifespan , sometimes of a large magnitude.
This is accompanied by prototypic cell cycle checkpoint activation and chromatin condensation.
This is accompanied by the increase of expanded clones of B cells , which correlates with poor health status.
This is a change from published significant 9-mo follow-up results for insomnia severity ( Insomnia Severity Index ) and sleep efficiency.
This is achieved using pre-calculated S-values of positron-emitting radionuclides of UF-NCI paediatric phantoms and published biokinetic data for various radiotracers.
This is a concern for older drivers , their families , and the public , as well as government agencies.
This is a critical time in neurotherapeutics.
This is a cross-sectional study.
This is addressed by focusing on the amplitude of the clinical EEG bands , and not the affected sleep events.
This is advantageous for reporting risk.
This is a learner-based activity.
This is a longitudinal study with multiple cohorts , carried out in the city of São Paulo , Brazil , since @number@
This is also because non-malignant tumours may present as GISTs and in these cases it is not recommended to run a PD.
This is also the case in the recently published study of de Vries et al.
This is also true for the older African American.
This is also true in the brain.
This is also well replicated in animal studies where aging females are shown to have more extensive brain tissue loss as compared to adult females.
This is a major cause of morbidity and mortality , and a significant burden for health care providers and the health system.
This is a mandatory step to the implementation of imaging biomarkers in clinical routine for early and differential diagnosis.
This is a multicenter retrospective cohort study among four Level II trauma centers.
This is an area for further research.
This is an area which potentially has important service implications.
This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms.
This is an effort to inform people about their options and wishes toward end of life.
This is an elastic artery , although anatomically it is considered to be medium-sized.
This is a new finding , not observed with conventional arterial stiffness indicators.
This is an important clinical problem shared equally by young adults transitioning from pediatric care and those presenting directly to adult care.
This is an important finding , as many radiologists do not report minor degenerative changes in the knee.
This is an important finding in understanding natural immunity against malaria , which is essential for making an efficacious vaccine.
This is an important issue because advanced parental age adversely affects babies in the short and long run.
This is an important topic to investigate as the goal of any audiological test is optimize the test's sensitivity and specificity.
This is a particularly important issue among disadvantaged older adults , who may benefit from stable networks.
This is a particular problem in histological analysis.
This is a population-based prospective study with @number@ individuals ( @number@ women and @number@ men , @number@ ± @number@ years ) who participated.
This is apparently why aging became a counterproductive atavism for these two species and was strongly shifted to late ages.
This is a promising alternative exercise method for maintaining physical activity and leads to improvements in physical performance.
This is a prospective observational study.
This is a prospective population-based study.
This is a protracted process , beginning in the third week of gestation and continuing into early adulthood.
This is a qualitative and quantitative study examining institutional staff members ' reactions to delusions experienced by nursing home residents.
This is a qualitative review of the evidence linking dietary fat composition to the risk of developing dementia.
This is a Quasi-experimental controlled trial.
This is a result as of experimental basis developments in biological research , so of information technology progress.
This is a retrospective data collection with follow-up analysis and a nationwide population-based dataset in Taiwan.
This is a review of the Medline literature evaluating NAFL and AFL for photoaging.
This is a safe procedure that can be done as an outpatient or in an office setting.
This is a significant health ( care ) problem , as regular PA has many health benefits also at advanced age.
This is a significant problem in long-lived cells like neurons , where pathway defects can result in the accumulation of aggregates containing ubiquitinated proteins.
This is a special time in woman's life , in which there are many metabolic changes , neurovegetative symptoms and mental changes.
This is associated with increased serum insulin , islet insulin content , and insulin mRNA in the O-GlcNAcase transgenic mice.
This is a step towards understanding this complex process in a particularly vulnerable population.
This is a study aimed at assessing the effectiveness of the new-lift technique for facial rejuvenation.
This is a substantial health concern as the trend for population aging continues to increase.
This is a task that should never be forgotten.
This is attributed to changes in diet , body composition , medication use , physical activity , and hormone levels.
This is a unique feature of the LC approach that is new as far as we know to the existing literature.
This is a very stressful situation for the caregivers of people with dementia.
This is based mostly on hearsay and anecdotal information.
This is because data from controlled manipulative experiments rather than observational correlations are preferred to solve this issue.
This is because : ( @number@ ) the procedure is iterative ; and ( @number@ ) kurtosis is more diagnostic than variance in identifying outliers.
This is because of the burden of chronic disease in the aging population and specifically chronic kidney disease ( CKD ) .
This is because trends in bathing were favorable whereas trends in other activities were not.
This is believed to undermine immunity to other pathogens and to accelerate immunosenescence.
This is caused by a relative insufficiency of osteoblasts compared with osteoclasts.
This is characterized by a delayed muscle activation following stimulus onset , and a significantly earlier recruitment of the antagonist muscle before movement onset.
This is characterized by recurrent abdominal pain and disturbed bowel habit.
This ischemic tolerance has been shown in numerous experimental models of cerebral ischemia.
This is concerning as B vitamin status is rarely fully assessed.
This is considered by some scientists as a more important evolutionary procedure than mutation based natural selection.
This is considered to be a specific phenomenon for postmenopausal breast cancer patients.
This is consistent with an increased rate of renewal of rod outer segments induced via increased phagocytosis by HIV-infected RPE previously reported in culture.
This is consistent with data indicating normative mitochondrial remodelling responses to long-term exercise training in the elderly.
This is consistent with other factors such as sedentarity , low protein intake , and concurrent diseases , being responsible for the sarcopenia of aging.
This is consistent with results from the @number@ published follow-up studies and in opposite direction of the original report.
This is consistent with the hypothesis of vascular mania.
This is contrary to case-control studies , and may introduce sample or ascertainment bias.
This is corroborated in mice ( mtDNA deletions @number@ vs @number@ pg / mL , p < @number@ ) .
This is due in large part to the relatively weak selection that applies to women near or beyond the end of their reproductive period.
This is due in part to the fact that ( despite improvements ) current anti-diabetic approaches are suboptimal.
This is due in part to the paucity of studies that take as their primary focus the older population and disasters.
This is due to endogenous collagenolytic enzymes , matrix metalloproteinases , and cysteine cathepsins , responsible for the time-dependent loss of hybrid layer collagen.
This is due to political unrest , limited health resources , and other pressing public health issues such as infectious diseases.
This is due to the fact that the volume of hippocampus is as small as 1 / 200 of the blood vessels.
This is due to their production of extra amounts of reactive oxygen species , which leads into progressive caspase-dependent apoptosis and cell death.
This is equivalent to @number@ points on the Barthel Index ( 0-20 scale ) .
This is especially true among elderly patients with existing risk factors for corrected QT ( QTc ) interval prolongation.
This is especially true at the level of endothelial cells : the attachment of AGE to RAGE receptor causes an increase in vascular permeability.
This is especially true for leg movements in relation to gait , where failed adjustments can lead to falls , especially in elderly.
This is especially true for nonverbal vocalizations such as laughter , sobs , or sighs.
This is especially true for users of targeted therapies and those who have a poorer health status.
This is especially true if the laboratory does not specify the age related normal values.
This is especially true in blacks of African descent but not in other ethnic populations.
This is especially true in old age.
This is essential as \ "sustainable \ " necessarily implies a time dimension.
This is evident in glucose hypometabolism and decline in mitochondrial efficiency which is sustained thereafter.
This is evident in the cortical plasticity resulting from compensatory reliance on the \ "good \ " forelimb in rats with unilateral sensorimotor cortical infarcts.
This is examined in the context of traditional story-based reminiscence as well as novel forms of song-based reminiscence.
This is expected to rise to @percent@ by @number@
This is experienced as a shamed masculine self given their inability to perform manhood acts , which leads them to severe social bonds.
This is explained by the fact that its practices are relatively recent and they question our relationship with death and dying individuals.
This is far less than would be predicted from the number of cases reported in children.
This is focused on macrolides , corticosteroids , and statins with respect to their modes of anti-inflammatory action , current status , and limitations.
This is followed by a longitudinal mixed-effects statistical model in the second stage for testing differences in shape trajectories between groups.
This is followed by an outline of the major mechanism underlying neuroprotection against neurodegeneration offered by caffeine and adenosine receptor agents.
This is further enhanced by using a machine learning method to accurately predict actual skin age.
This is further evidence for the potential role that sleep disturbance plays in the heterogeneity of PD.
This is higher than levels reported in earlier surveys.
This is , however , impossible within the approach van der Klink et al provides.
This is important as they can co-shape the societal impacts during the developmental process of technologies and thereby stimulate responsible innovation.
This is important because therapy decisions are often made as a direct result of MRI.
This is important for many health-related tasks and for maintaining independence in daily living activities.
This is important for understanding mechanisms of age-related axon loss and age-related axonal disorders.
This is important given the high mortality and morbidity associated with this population.
This is important in order to determine the strategies used during the DT test protocols , i.e. cross-domain interference.
This is important knowledge for health care staff to bear in mind at nursing homes when encountering spouses.
This is in accordance with the established mitochondrial dysfunction in PD and provides evidence for mitochondrial impairment at the transcriptional level.
This is in contrast to earlier studies that used a less realistic walking scenario and found an age-related decay even for MI means.
This is in contrast to the continuously elevated levels that are characteristic of other hypercortisolemic states , e.g. Cushing ' s disease or major depression.
This is in contrast to what is observed in healthy middle-aged and older aerobic exercise-trained men.
This is inconvenient for nonspecialists to interpret and makes it difficult to use as an entry criterion for clinical studies.
This is informative biologically , because the SLCO1C1 protein transports thyroid hormone into astrocytes from blood.
This is in large part due to the increase in obesity and the aging of the population.
This is in large part due to the lack of physical tools for probing cellular heme.
This is in line with observed favourable effects of practicing arts on health in the short-term.
This is in part because of the recent development of methods for breaking the spore wall and extracting biocompounds from the spore.
This is in part because performance in children depends on stimulus parameters.
This is , in part , due to a lack of available diagnostic testing and uniform diagnostic criteria.
This is , in part related to differences in linkage disequilibrium and allele frequencies between ethnic groups that could lead to confounding.
This is in sharp contrast to the response observed in young adults after ConA stimulation where cells increase in telomere length and replicative capacity.
This is known as the paradox of well-being.
This is largely attributable to the spatiotemporal intratumor heterogeneity during metastasis.
This is largely due to complex and dynamic cross-talks that occur among multiple cell types throughout the aging process.
This is likely due to the human HSC population becoming more clonal with age , selecting for myeloid-biased HSC clones.
This is likely to cause undertreatment among the old.
This is likely to have important implications and may partly explain socioeconomic inequalities in health and physical functioning.
This is little more than would be expected by chance.
This is made possible through the conservation law of momentum derived from LDDMM.
This is mainly attributed to the loss of synaptic connectivity , which is a feature commonly observed in neurodegenerative disorders.
This is mainly because WMH may reflect co-morbid neural injury or cerebral vascular disease burden.
This is mainly due to less stringent use of proteasome inhibitors and IMiDs , increased toxicity , and subsequent early discontinuation of therapy in elderly.
This is mainly due to the corresponding changes of the biomechanical parameters of human bone presents with aging.
This is mainly due to their crucial role in energetic balance , in modulating epigenetic programs and in influencing cell stress response.
This is maintained at least @number@ months after treatment.
This is mediated by hepcidin's interaction with the iron-exporter ferroportin , to adapt intestinal iron absorption and body iron-sequestration to changes in demand.
This is most challenging for emergency and critical care.
This is not a new concept , but until now the scale of the potential microbiota contribution was not appreciated.
This is not coherent with a good patient care and we thus need to develop new eGFR equations with better agreement between the estimates.
This is not due to changes in the optical alignment , since angle kappa did not vary significantly with age.
This is not only due to a higher incidence of diseases that cause dysphagia , but also to age-related changes in the mechanisms of swallowing.
This is not surprising since bones adapt their morphology and strength to the long-term loads exerted by muscle during anti-gravitational and physical activities.
This is observed more and more as the population is aging and the number of spine surgery is increasing.
This is , of course , an issue of patient selection and not product selection.
This is often due to elderly evacuees getting overlooked in the chaos of an initial response.
This is often not described in package inserts.
This is one of several epidemiological obstacles discussed.
This is only true in part , because of the elderly population of reference.
This is owing to a range of factors relating to participating staff and clients , as well as the broader institutional context.
This is paradoxical as generally , cognitive function is positively associated with TBV.
This is paralleled by an age-dependent transcriptional downregulation of the low-affinity A2B receptor.
This is partially reflected by the abnormal mechanisms of cortical neural synchronization and coupling that generate resting state electroencephalographic ( EEG ) rhythms.
This is particularly apparent for complex disease.
This is particularly apparent in Plasmodium knowlesi malaria.
This is particularly applicable when choosing a cream or ointment and the active substances.
This is particularly as patients are often discharged home within 4-5 days after surgery.
This is particularly important for older adults as they are at higher risk for cancer.
This is particularly important in view of the extensive medication prescribing and exposure in older adults.
This is particularly relevant for China , where an extremely large population is growing , aging , and urbanizing.
This is particularly relevant to the observed demise of peroxisome function which accompanies cellular senescence , organismal aging , and age-related diseases.
This is particularly so during the transition to care homes , where previous aspects of identity and social roles may be lost.
This is particularly true for older , frail and medically complex HF patients , many of whom require home care services.
This is particularly true for older minority groups where the place that they have migrated to presents both cultural and structural challenges.
This is particularly true of the collagen network , which is susceptible to cleavage once proteoglycans are depleted.
This is particularly true with regard to various issues related to the social insurance system , such as family caregiving and work capacity assessment.
This is partly attributed to historical experiences as well as their cultural beliefs.
This is partly due to older adults difficulties to apply explicit knowledge.
This is partly due to the inability to identify and intervene in an effective therapeutic window early in the disease process.
This is partly the result of death on the waiting list but may also be related to organ allocation policies.
This is possible thanks to the cellular mechanisms of bone modeling and remodeling called adaptation.
This is possible today thanks to new imaging techniques enabling non-invasive diagnosis of adenomyosis.
This is possibly attributable to a more intensified HF medical therapy in the NT-proBNP-guided group.
This is possibly related to lower residence times of MMHg in the Itenez compared to the Beni River floodplains.
This is potentially because fatty acid metabolism is disturbed in APOE4 carriers compared to the non-carriers.
This is presumed to result from capacity limitations in relevant brain regions.
This is probably due to a number of confounding factors , particularly in studies of a cross-sectional nature.
This is probably the result of a survival effect.
This is problematic , as before such claims can be made , such relationships need to be tested with SE as criterion.
This is proposed as the basis for Marx's line , a line of staining with topically applied dyes that lies directly behind the MCJ.
This is raising the hypothesis that chronic immune activation may cause the premature aging of the immune system.
This is rare and no other reports have been published ; hence , further such cases need to be highlighted.
This is recognised to impact on patient outcomes and health costs.
This is reflected in a @percent@ decreased cell number , and @percent@ lower CSF hypocretin-1 levels.
This is regulated by control mechanisms.
This is relevant when planning interventions for maintaining independent living in ageing.
This is remarkable , because Dutch policy makers have increasingly encouraged family members to take on an active role in caring for dependent relatives.
This is remarkable because the same signaling molecules , oncoproteins and tumor suppressors , are well-known targets for cancer therapy.
This is sarcopenia.
This is similar to the increase reported for motion bandwidths in senescent monkeys.
This issue can be studied in humans because several non-invasive brain stimulation techniques induce synaptic plasticity in the human brain.
This issue even resulted in a Senate Hearing before the Special Committee on Aging.
This issue has not been adequately addressed in the context of patient cohorts.
This issue is addressed in the donepezil treatment of cognitive impairment and depression ( DOTCODE ) pilot clinical trial.
This issue is clinically important because verbal memory scores are used in diagnosing aMCI and AD dementia.
This issue is exacerbated for rural Latino populations.
This issue is important to clarify since signalling and \ "trans-signalling \ " affect different tissues.
This issue may be particularly relevant in the aged-care residential sector , where very high rates of depression and poor QOL are evident.
This is supported by an in-depth analysis of VZV , measles and parvovirus B19 antibody titers.
This is supported by neurophysiological data on motion perception in senescent monkeys.
This is surprising , since multimorbidity is a particular challenge for both general practitioners and patients.
This is the basis of its anti-aging activity.
This is the basis of presbyopia.
This is the basis of the ambivalent ( Jekyll-Hyde ) situation of ROS in biology and pathology.
This is the case for rat , hamster and mouse , three chronobiological model rodent species studied by us.
This is the first and the largest study to provide evidence that BLM is a promising biomarker in breast cancer.
This is the first antimicrobial pilot study in late elderly patients with nursing and healthcare associated pneumonia.
This is the first application of the validated Hebrew version of this questionnaire to Israeli nurses in order to evaluate factors affecting their work ability.
This is the first case of KS reported in a family of Iranian ancestry.
This is the first chronological evaluation of aMPFA and aLDTA from a relavively large series of patients.
This is the first comprehensive cohort study of the health of older people ever conducted in Iran.
This is the first comprehensive review of RVT based on a broad , unifying mechanism.
This is the first demonstration of specific modulation of urothelial ATP release in native tissue by purinergic and muscarinic neurotransmitters via distinct mechanisms.
This is the first demonstration that the E47 @number@'UTR directly regulates its degradation.
This is the first description of a patient with BD harbouring a variant whose origin is either de novo or the consequence of gonadal mosaicism.
This is the first empirical study to examine the effects of PFL on long-term care patterns.
This is the first human test of mitral loop annuloplasty.
This is the first investigation about the meaning of the taken-for-granted concept from the perspective of a group of older survivors.
This is the first in-vivo study to evaluate age-related changes in TSPO binding , using the new generation TSPO radioligands.
This is the first longitudinal study showing positive effects of a lean body on cortical development in children.
This is the first of a two-part article on inflammatory processes in aging.
This is the first of three reviews focusing on OA therapeutics.
This is the first population-based study to assess item nonresponse to sexual orientation measures by age and change over time.
This is the first prospective study to show that looking old for your age is a marker of poor cardiovascular health.
This is the first psychometric study to use the GPS as an age-specific screening instrument for PDs.
This is the first published report of the prevalence of dysphagia in older community-dwelling Koreans.
This is the first report describing a link between routine clinical laboratory data and genomic aging.
This is the first report investigating the biological activities of microalgae-derived MAAs in human cells.
This is the first report linking a molecular pathway to specific phenotype expression in FTLD-GRN.
This is the first report of a kidney-localized case in Japan.
This is the first report of a physiological mechanism of ET3 induction.
This is the first report of calcium hydroxylapatite-induced skin necrosis.
This is the first report of familial PD because of the LRRK2 p.R1441G mutation in Asia.
This is the first report of realistic complex packaging opening loading presented in the literature.
This is the first report of short-term studies for this system.
This is the first report on the association of XPD Asp312Asn polymorphism with maturity onset cataract.
This is the first report on the effect of aging on probable CTS risk factors.
This is the first report providing evidence of NET production induced by cationic liposomes.
This is the first report showing the relationship between wild-type transthyretin deposition and aging in familial amyloid polyneuropathy patients.
This is the first report that confirms the presence of functional CB1 and CB2 receptors on KU-812 cells.
This is the first report that GABAergic stimulation increases Klotho expression.
This is the first report to suggest that the conformity index tumor coverage may be an important predictor of hearing outcomes.
This is the first study demonstrating an association between short TL and increased mortality in a population of non-European ancestry.
This is the first study demonstrating that home-based dual-task training can be effectively implemented to improve balance performance during gait in older adults.
This is the first study on a primate model of human HD based on longitudinal clinical measurements.
This is the first study reporting CV effects following low dose proton and iron ion irradiation during normal aging and post-AMI.
This is the first study to analyze the associations between polymorphisms in WRN , BLM and RMI1 and CRC risk.
This is the first study to demonstrate that alERC volume is related to cognitive decline in undiagnosed community-dwelling older adults.
This is the first study to demonstrate that a manipulation of stimulus novelty can alter age-related associative deficits.
This is the first study to examine associations between endogenous estrogens , telomere length and telomerase activity.
This is the first study to examine changes in objectively measured PA and cognition over time in HF.
This is the first study to examine pathways of mitochondrial quality control in aging human skeletal muscle with aerobic exercise training.
This is the first study to examine whole-brain network activity in young or old nonhuman primates while they actively or passively traversed an environment.
This is the first study to find indirect associations between negative emotionality and peak to bed cortisol slopes through depressive symptoms.
This is the first study to report prevalence figures for depressive symptoms in this population.
This is the first study to report that testosterone deficiency and severity of ED are both independently associated with reduced QoL in men with T2D.
This is the first study to show that both sensory abnormalities and aging impact on speech encoding in ASD.
This is the first study to show the interaction between APOE and depression to be dependent on timing of depression onset.
This is the first study to test the age × genotype interaction in IGF-1 levels.
This is the first such study conducted with American Indians.
This is the first systematic investigation of neural correlates of FR during SD.
This is the first time many of these constructs have been measured in a nationally representative sample.
This is the first time that a quantitative phenotypic distinction between these two diseases has been achieved.
This is the first time that a two-feature biomarker classification system has been applied to a population-based cohort.
This is the first time that label-free quantitative proteomics has been applied to study of aging mechanisms in human skeletal muscle.
This is the first time that pathogenic coding mutations in the PS1 gene have been shown to lower PS1 gene expression.
This is the first time that spine societies and industry partners have collaborated to support evidence development.
This is the fourth demographic report for the UK , providing an overview of the latest statistics on the population.
This is the main reason for the structural changes in trabecular and cortical bone , which is reflected in reduced biomechanical strength.
This is then followed by discussions on some of the DAMP-mediated neuroinflammatory responses involved in chronic neurodegenerative diseases.
This is the own-age bias.
This is the result of increased postoperative insulin sensitivity and β-cell secretion.
This is the second part of a 2-part report on spontaneous activity in pet dogs.
This is the starting point of the research group FANS aiming for developing a pedestrian assistance system for older road users.
This is the theme of the research to be presented at this MMVR workshop.
This is thought to reflect fetal programming , the phenomenon whereby nutrition and other influences during development set the body's organs and systems for life.
This is through direct oxidation of key autophagy-related ( Atg ) proteins Atg3 and Atg7.
This is time-consuming and subject to interpersonal variability.
This is troubling , given the health disparities among incarcerated populations.
This is true for any age group , and sexuality is seen as an essential element of marriage for couples of advanced age.
This is true for high- as well as low- and middle-income countries.
This is true regardless of whether objective or subjective measures of SES are used , where both are important measures of SES in elderly adults.
This is unfortunate because much may be revealed about the nature of concept learning by examining the limits exhibited by special populations.
This is unfortunate given that older adults are less likely to tolerate moderate- to high-intensity statins.
This is well known for relative derivatives , e.g. diisopropyl fluorophosphate.
This is why the RCTs , in addition to the ATE , also present the results of subgroup analysis for preestablished subgroups.
This is why we should recognize the pathobiology of COPD as involving a complex interaction between several factors , including genetic vulnerability.
This is worse in people with xerostomia where chewing and swallowing are impaired anyway.
This knowledge gap is impeding the finding of new cancer therapy targets and the development of novel treatment strategies.
This knowledge indicates areas for improved activity provision and health care support.
This knowledge is essential for developing effective therapies to treat progeria and may help identify new mechanisms underlying normal aging.
This knowledge may facilitate further improvement and development of interventions to reduce concerns about falling and to increase daily activity.
This knowledge provides justification for implementing NODDI metrics in developmental studies.
This lack of consistency hampers progress in identifying the contribution of SVD to the pathophysiology and clinical features of common neurodegenerative diseases.
This lack of knowledge and understanding was more apparent among the elderly women in the group.
This lack of publication belies the observation that research with older people could benefit from the positive approach entailed in an AI approach.
This lag time has an extraordinary value of @number@ to @number@ years , larger than that previously used or found in miner studies.
This large body of work has produced important insights but also contains numerous problems and weaknesses.
This large sample was collected in a Web survey for behavioral correlates of the CIRENS with variables previously associated with chronotype differences.
This large-scale study had two goals.
This late maturation may reflect a long developmental period for cortical networks underlying global motion perception.
This latter difference increased over time between @number@ and @number@
This latter finding suggests that physicians and family members may understand cognitive symptoms differently.
This latter , in particular , was considered not relevant for a long time.
This latter results indicates that the collaborative effect of both hypothesis are needed to induce wrinkles in the fingertips.
This lays a foundation for further study of the role of apoE in the aging process of fish.
This leading cause of blindness is becoming increasingly more prevalent in the aging population.
This leads to a consideration of the mechanisms of action and role of ApoE and its modulation by DHA.
This leads to a different peak concentration just prior to the next monthly injection.
This leads to a macrostructural failure and to the development of \ "fatigue \ " fractures.
This leads to an increased susceptibility of collagen toward proteases , whereas recombinant periostin protects collagen fibrils from degradation.
This leads to a reduction in the expression and activity of both COX and NOS.
This leads to a wrinkled appearance through the inhibition of transforming growth factor-β ( TGF-β ) / Smad signaling.
This leads to defective chromosome segregation and accumulation of CFS-associated DNA damage in G1 cells.
This leads to globular , glycolytic , lipogenic and ATP-deficient astrocytes , cerebral characteristics common in AD patients.
This leads to great uncertainty in everyday clinical practice.
This leads to increased capital per worker even as aggregate saving rates fall.
This leads to less efficient protein degradation and hence more aggregation suggesting that there is a vicious cycle.
This leads to mitochondrial membrane hyper-polarization , PINK1 cleavage and defective mitophagy.
This leads to storage of a modified spatial and temporal motor pattern that is expressed as an aftereffect in regular walking conditions.
This leads to the compact linear representation of the nonlinear diffeomorphisms in terms of the initial momentum.
This leads to the idea that ageing is a result of a chronic inflammation process and to the term \ "inflammageing \ ".
This leads to the proposed approach named as functional mixture regression ( FMR ) .
This leads to the rapid increase in the incidence of kidney diseases with aging.
This leads us to reconsider the role of alternative splicing in duplicate retention.
This leaves room in the resin for substantial reinforcement fillers.
This led to an estimated direct health care cost of $ 75 billion and an indirect lost opportunity cost of $ 11 billion.
This led to identify @number@ differentially expressed protein markers between tumors and normal samples.
This led to @number@ predominately right-hemispheric regions.
This led us to hypothesize that Aβ exerts its toxic effect , at least in part , by causing damage to biological membranes.
This leftward bias has been attributed to hemispheric lateralization or experiential factors.
This level of expression is significantly higher in photoaging than in chronological aging.
This level of mtDNA depletion significantly decreased mtDNA gene transcription and translation , resulting in reduced mitochondrial respiratory capacity and ATP production.
This lexical effect on articulation , however , appears to be constrained by PD.
This liaison between attention and WM poses several interesting empirical questions.
This likely contributes to why LDL-C in women increases in this period.
This likely reflects the complex interplay between the mnemonic positivity bias , structural WM integrity , and functional brain compensatory mechanisms in older age.
This likely underlies and bi-directionally interacts with its diverse toxicological profile and is of considerable public health and regulatory importance.
This limitation has by many experts been attributed to limitations in cognitive resources.
This limited duration of response may be due to AChE upregulation caused by chronic inhibition.
This limits their utility as tools to select patients for acute stroke interventions.
This linkage opens new dimensions for ginseng pharmacology and LPA therapeutics.
This link may have implications for the management of sleep disorders in older people.
This link may help to elucidate mechanisms of neurotoxicity.
This link was first discovered because of a link between longer telomeres and a high number of naevi.
This lipid accumulation in the liver was due to the dysregulation of PPARα and SREBP1c.
This lipid analysis shows an exquisite acyl chain specificity and plasticity in the perturbation of PA metabolism.
This literature analysis of traditional medicinal uses and experimental chemical and pharmacological data of Hippocampus provide a scientific basis for future research.
This literature review addresses the current state of research in this area.
This literature review allows to identify predictors of frailty considering its physical , psychological and social domains.
This literature review identifies factors associated with employment in patients who underwent OLT.
This literature review summarizes the current knowledge on mitochondria-targeted antioxidants and their contribution to the body's antioxidant defense system.
This literature search limited included studies to randomized controlled trials which implemented a structured physical activity intervention for middle- and older-aged adults diagnosed with cancer.
This literature search yielded thirty-eight studies.
This locus harbors an evolutionary conserved gene-desert region with non-coding intergenic sequences likely involved in regulation of protein-coding flanking genes ZEB2 and ACVR2A.
This longitudinal analysis included @number@ older men participating in the VA Normative Aging Study.
This longitudinal phenotyping strategy in SNCA-OVX mice thus provides insights into the region-specific neuronal disturbances preceding and accompanying Parkinson disease.
This longitudinal study analysed 25 ( OH ) D and the risk of cognitive decline among non-demented older adults.
This longitudinal study examined dyadic and triadic skills in @number@ preterm and @number@ full term infants at @number@ @number@ and @number@ months of age.
This longitudinal study investigated proinflammatory cytokines and comorbidity development over time among breast cancer survivors and a noncancer control group.
This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists.
This longitudinal study was based on the largest sample and the longest time period studied to date.
This long-term depression of elderly fallers in these aspects may be more extent than previous assumed.
This loss of ATP synthesis eventually results in cellular metabolic failure and necrotic cell death.
This loss of bony volume and projection may contribute to the aged appearance.
This loss of the adult-associated microbiota correlates with measures of markers of inflammation , frailty , co-morbidity and nutritional status.
This lower risk was found for persons with normal cognition or MCI.
This lower utilization may be due to barriers to access rather than better health.
This maintenance defect can be explained by an abnormal firing pattern during the consolidation phase of structural plasticity in KI neurons.
This maintenance of muscle mass in masters cyclists may preserve walking performance to similar levels as moderately active young adults.
This makes a comprehensive quantification of young healthy balance performance possible.
This makes complex the analysis of biological networks associated with multiple clinical traits.
This makes exogenous T administration inappropriate for men who wish to father children.
This makes GM a possible factor counteracting the genetic determined acceleration of immune senescence in DS persons.
This makes it difficult to determine if observed changes are due to variations in myelin content , or simply due to measurement error.
This makes it necessary to create animal models for studying AMD pathogenesis and to design new therapeutic approaches.
This makes RBCs highly sensitive to any aberration.
This makes therapeutic decisions complex , especially in emergency situations.
This makes the scale a valuable measure in determining both basic and instrumental activities of daily living.
This manipulation regulated the availability of coarse-scale relative disparity cues.
This manuscript improves upon the statistical methodology for SST and QC that is currently used in proteomics.
This manuscript outlines a case study of systematically developing visual demands analyses and pre-placement vision screening assessment protocols for individuals completing quality inspection positions.
This manuscript provides a step-by-step protocol supplemented with methodical notes for performing the technique.
This manuscript tries to provide a guideline on how these markers can be integrated in future research aimed at providing such data.
This manuscript will address the evidence for links between telomere biology , skin phenotypes and cancer risk.
This marked change in gene expression necessarily implicates a global regulation of chromatin remodeling.
This marker is reflected in mechanical properties of hair.
This marks the importance of considering PCI treatment , a reliable strategy in cases of IOD or long occlusion duration.
This Masterclass presents an overview of LSS in terms of clinical examination , diagnosis , and intervention.
This material breaks up the collagen fibers of most of the dermal plane.
This mathematical model employs a robust and parameter-free synchronization metric.
This may account for the fact that antioxidants prevent some aspects of cyanide-induced neuronal damage.
This may affect the longitudinal contribution from atrioventricular plane displacement ( AVPD ) and septal and lateral contribution to stroke volume ( SV ) .
This may apply to some short-lived species such as Drosophila , but not to some long-lived species such as the queens of ants and bees.
This may arise due to a decrease in peak L-type Ca ( 2 + ) current.
This may assist in developing and evaluating intervention to decrease caregiver burden.
This may assist the elderly in preserving their independence.
This may be a barrier for LGB residents , making the expression of their sexual identity more difficult and leading to discriminatory practices.
This may be an acceptable alternative method when knee height measurement is difficult or when the knee height caliper is not available.
This may be applied for evaluating potential therapeutic strategies and outcomes in the future.
This may be associated with a mechanism ( s ) other than central command.
This may be associated with lower incidence of Atherosclerosis or intimal hyperplasia in ITA samples even in elderly cases.
This may be conceptualized in the context overlapping symptomatology in gastrointestinal conditions and anxiety.
This may be contributory to the occurrence of nontraumatic vertebral fractures in elderly subjects with reduced bone mineral density.
This may be correlated to the protective effect of the bioactive substances that are present in fruits and vegetables , in particular flavonoids and carotenoids.
This may be different for long-disabled populations , which would have consequences for validity of frailty measures.
This may be due in part to the lack of brief dementia screening tools available to clinicians.
This may be due in part to the relationship of LTL with other biomarkers associated with cardiovascular disease risk.
This may be due to a lack of cultural sensitivity of the care-providers and a lack of knowledge about HPC among immigrants.
This may be due to a lack of evidence examining the benefits of palliative care for these patients.
This may be due to alterations in red blood cell properties related to the storage process.
This may be due to both genetic and epigenetic inheritance.
This may be due to neural reorganisation arising from sign language use.
This may be due to reduced differentiation capacity or deficiency in DNA damage repair ( DDR ) factors.
This may be due to the combined impact of multiple comorbidities and frailty.
This may be due to wallerian degeneration secondary to neurodegenerative changes.
This may be exacerbated by underlying comorbidities which preclude or limit the utility of some therapies including medications.
This may be in line with older adults ' motivational goals to avoid risks in social interactions.
This may be in line with the notion that empathizing and systemizing compete neurally in the brain.
This may be largely attributable to inconsistency in study results that fail to fully inform the clinical and public health community of its overall value.
This may be linked to effects on innate immune function.
This may be of benefit in preventing falls.
This may be one of the brain's mechanisms mediating the reserve effects found in people with higher education.
This may be partly due to the inherent unpredictability of final-stage COPD compared with lung cancer.
This may be related to mutual compassion , a characteristic of the We / Us approach , which may be protective.
This may be related with a higher incidence of infectious and chronic diseases.
This may be responsible for the development of detrusor overactivity progressing to detrusor underactivity and inability to empty the bladder.
This may be the reason why PTT dysfunction leads to an acquired flatfoot deformity.
This may be the result of a larger variety of physical activity programs offered at this type of institution.
This may be useful as a standard value for this age group.
This may be valuable information with a view to the therapeutic use of AFMSCs.
This may contribute to a higher level of oxidative stress that overwhelms antioxidant defense in these neurons , leading to their increased vulnerability in PD.
This may contribute to decreased ability of an elderly patient to mount an appropriate innate inflammatory response when injured.
This may enable early initiation of preventative therapies.
This may enable health care professionals to meet psychological needs alongside biological needs during nutritional interventions.
This may enable rates of morbidity and mortality to fall.
This may especially be the case for the most vulnerable and inactive older persons.
This may explain prior inconsistencies and help develop BTL as a cancer detection biomarker.
This may explain why , in cases of trisomy , the effect of overexpression can be attenuated.
This may explain why LH did not evolve into CG in ruminants and consequently alternative mechanisms evolved to delay luteolysis early in gestation.
This may have been because the drug was administered too late to prevent IC coupled with an overall low number of IC events.
This may have contributed to the reduction of mortality rates and to the improvement of cancer survival.
This may have implications for the legal system , particularly with eyewitness testimony.
This may have implications on therapeutic management and secondary prevention.
This may have important consequences for the exposure to contextual health risks.
This may have links to various cognitive effects of GH and IGF-1.
This may have pathological implications for bone-specific disorders such as otosclerosis.
This may help inform prevention strategies for dementia or AD in older men with sleep apnea.
This may help prevent social isolation among older people and contribute to overall well-being in aging societies in Japan and abroad.
This may help to develop strategies to improve the quality of care that senior citizens receive from their GP.
This may improve functional ability.
This may indicate strain due to task demands , eventually resulting from the deployment of compensatory processes.
This may influence or reflect different stages of the development of protective schistosome acquired immunity and immunopathogenesis.
This may influence the choice of therapy , such as steroid dosage and the use of immunosuppressants.
This may in part explain the higher rates of hip fractures in the elderly.
This may in turn relate to dysfunction of the prefrontal-noradrenergic network responsible for coordinating switching behavior.
This may involve an abnormality in the process of extracellular matrix remodelling.
This may lead to a positive impact in the general health of the caregiver , eventually resulting in better care of the AD patient.
This may lead to interference between the two tasks , manifested in a decreased performance in one or both tasks ( dual-task costs ) .
This may lead to iron deposition and oxidative mitochondrial injury.
This may lead to lower naïve T cell output and limited TCR diversity.
This may mean reexamining the health implications of adding large amounts of antioxidants to foods.
This may negatively impact on the fidelity of information available to higher cognitive processing.
This may not only benefit skin and tendon but also other long-lived protein tissues in the body.
This may occur because standardized scores inherently adapt to the noise level , independently of the shape of the distribution of the wavelet coefficients.
This may partly explain how gait changes emerge with aging.
This may partly reflect avoidance of tasks involving disinfectant use , and may introduce bias in cross-sectional studies on disinfectant exposure and asthma in nurses.
This may place older adults at risk of overbalancing.
This may provide a first step in clinical differentiation of hippocampal sclerosis associated with ageing versus pure Alzheimer's disease in their earliest stages.
This may provide insight into identifying which patients older than @number@ years of age may benefit from aggressive surgery.
This may reduce risk for chronic age-associated diseases and promote healthy aging and longevity.
This may reflect a specific role of TOMM40 \ "523 \ " in the pathogenesis of LOAD.
This may reflect CMV infection reactivation to be more common in the end stages of life.
This may reflect structural changes in the RNFL that are evident despite the absence of OIs.
This may represent an age-related reduction of right hemispheric dominance and / or increased left hemispheric involvement.
This may represent an antioxidant response , diminishing the flow of electrons to the respiratory chain and protecting sulphydryl residues from oxidative damage.
This may represent a novel strategy to control proliferation of prostate cancer through modulation of the host microenvironment.
This May result in a decline in the use of health resources , which entails significant socio-economic benefits.
This may result in increased structural interference and higher dual-task interference in older adults.
This may significantly improve the clinical decision-making.
This may stem from specific age-related impairment of muscle signaling and from decreased nutrient and growth factor delivery to the muscle.
This may suggest a causal relationship between the lifespan of an organism and its metabolic phenotype.
This may suggest that cardiovascular drugs were withheld because of serious co-morbidity or that concurrent illness can preclude benefit from cardiovascular prevention.
This may suggest that the use of \ "universal \ " cut-off points is probably misleading.
This may warrant further studies.
This meaning is expressed by constructing their self-dentity and accepting their way of life.
This meaning is expressed by constructing their self-dentity and accepting their way of life.
This means periodicity can be estimated nondestructively but is reliant on all perikymata being visible along the crown surface.
This means that , especially , younger workers ' motivation increases as they are offered more career opportunities.
This means that hearing thresholds which reflect hearing acuity will , on average , increase over time.
This means that @percent@ of patients with a chronic disease had @number@ or more additional diseases not included in the @number@ most frequently occurring diseases.
This means that some daily activities are erroneously signaled as fall , which in turn leads to frustration of the users.
This means that the average structure seems to predict the average performance.
This means that the elderly who do not have depression symptoms attempt suicide according to their own situations and characteristics.
This means that there were no significant changes in their lifestyle during the experimental period.
This means these reproductive variables may be considered as novel biomarkers of bone health during male aging.
This measure may be useful for early detection of LS.
This measure may be useful in clinical practice for early identification of at risk patients.
This measure may contribute to future research on the role of close interpersonal contexts on the promotion of active aging among elders with chronic pain.
This measurement may be a useful surrogate endpoint of disease severity in FTD clinical trials.
This measurement of Sirtuin @number@ in the Hippocampus has become a reliable indicator for detecting potential longevity of an individual.
This measure should prove beneficial for researchers investigating multisensory speech recognition , since it relates to normal-hearing and aging populations.
This measure was assessed after participants returned home ≥6 months after stroke.
This mechanism accounts for the possibility to retain adequate physical activity of the organism up to the age of @number@ years.
This mechanism is not affected by aging.
This mechanism may contribute to the neuro-protective , cardio-protective , and life-prolonging effects of aspirin.
This mechanism may contribute to the pathogenesis of vascular diseases in HGPS patients.
This mechanism of telomere elongation previously had been found only in cancer cells lacking telomerase activity.
This mechanism results in an aging process in the chess game-line choice as the database grows.
This meeting report summarizes talks and gives some outlook into future developments.
This meeting summary covers some of the conference highlights.
This MEMRI approach represents the first diagnostic measure of neuronal dysfunction in mice.
This meta-analysis aimed to determine whether there is an association between sarcopenia and cognitive impairment.
This meta-analysis aims to consolidate previously published data to identify the risk factors most likely leading to TIC.
This meta-analysis also implicated the 5q11.1 locus in CBE risk.
This meta-analysis is registered at ClinicalTrials.gov , number NCT02438488.
This meta-analysis motivated the FDA's draft guidance for using pCR as a surrogate endpoint in accelerated drug approval.
This meta-analysis suggests that red meat subtypes differ in their association with CRC and its sub sites.
This meta-analysis tests whether the CHRNA5 variant rs16969968 predicts age of smoking cessation and age of lung cancer diagnosis.
This metabolic reprogramming , known as the Warburg effect , provides tumor cells with the substrates required for biomass generation.
This metabolic shift is epigenetically enforced , as is insulin resistance to reduce mitochondrial turnover.
This metabolite is subsequently eliminated by renal route while M1 formation will in part depend on ontogeny , i.e. , age-dependent activity and CYP2D6 polymorphisms.
This method and index provide evidence of neurological changes after stroke and aging by complexity analysis of the surface EMG signals.
This method can help to discover new acyl lysine modifications that can be removed by novel sirtuin activities.
This method has been used in various studies to investigate the interaction of carotenoid antioxidants and free radicals in human skin.
This method has not been tested in a large non-demented population in comparison with volumetry measurements.
This method has the ability to investigate renal microcirculatory damage during healthy aging.
This method has the advantage of being fast and allowing quantitation.
This method has the potential to facilitate research on the mechanisms of cognitive reserve and the efficacy of interventions designed to impart reserve.
This method integrates both specific and nonspecific approaches toward sensitivity enhancement for artifact-free quantification of labile plasma thiols without complicated sample handling.
This method may thus represent a more precise instrument to identify potential clinical outcomes in clinical trials for disease modifying drugs.
This method offers a new tool in microfluidic cell culture technology for biological analysis and it expands the field of microfluidic cell culture.
This methodology affords the ability to dynamically catalogue and quantify , in parallel , femtomole quantities of cellular metabolites.
This methodology can be applied to various RMDs , including endoscopes.
This methodology is based on matrix-assisted laser desorption / ionization mass spectrometric imaging ( MALDI-MSI ) .
This methodology may be useful in scenarios with large numbers of collinear covariates or in certain cases where latent class model assumptions are violated.
This methodology was then applied to data from normal elderly subjects from the Cache County Study on Memory and Aging.
This method produces more accurate estimates of summation area than conventional methods that simply increase overall stimulus dimensions.
This method proves to be much more selective than traditional intense pulse light ( IPL ) photorejuvenation.
This method , thus , might be suggested as a potential biomarker to objectively identify persons at risk for sarcopenia.
This method was shown to be an effective for viewing 3D stereoscopic images without causing discomfort.
This method will be used for the development of Life-support robots and prototype assistive technologies.
This microbiota is relatively stable throughout adult life , but may fluctuate over time with aging and disease.
This microglia activation was more pronounced in the normal-appearing white matter of patients in comparison to controls and increased with disease duration.
This microstate occurred irrespective of the visual stimulus presented.
This might be achieved by existing treatments such as theophylline , nortriptyline , and macrolides , or more selectively by PI3kinase-δ inhibitors.
This might be a natural sign of aging or an early indication of hemodynamic aspects of cardiovascular diseases.
This might be because the underlying pathology of white matter lesions ( WML ) is diverse and cannot be properly appreciated with conventional FLAIR MRI.
This might be due to cell-intrinsic changes in stem and progenitor cells or to influences by the microenvironment.
This might be due to generation of single-stranded regions and destabilization of hydrogen bonds.
This might be due to increased glycation , as well as changed isoforms of collagen in the aortic wall with age.
This might be due to less predictable disease trajectories and prognosis of death in chronic obstructive pulmonary disease.
This might be indicative of cautious behavior towards a potentially toxic treatment regimen.
This might be related to cumulative exposure to oxidative stress and inflammation in MDD.
This might cause them to withdraw socially and apparently ' lose their minds'.
This might depend on several mechanisms , including physical illnesses , alterations in the CNS and immune-endocrinological alterations.
This might explain the poor evolution of the life expectancy in countries with a high amount of private resources devoted to health.
This might explain the precedence of H-1 VP2 protein over KRV in determining oncolytic activity in human cancer cells.
This might indicate a greater plaque accumulation in a clinical situation.
This might indicate impaired encoding and consolidation processes at an early stage of episodic memory acquisition.
This might provide a link between air pollution and atherosclerotic cardiovascular diseases.
This might reflect methodological differences but possibly also the pathophysiological heterogeneity of the disorder , i.e. the age at onset of OCD.
This might , though , be due to differences in genotyping procedures and investigated SNPs , potentially inducing differences in the coverage of gene regions.
This migration was significantly decreased by F1 treatment in senescent astrocytes.
This mini-review aims to illustrate a unique regulation of PCD in NSCs.
This mini-review briefly covers several evolutionary , ecological , and physiological aspects that may contribute to the phenomenon of birds ' longevity.
This Mini-Review examines sex differences in the immune response to experimental stroke and its implications for therapy development. © @number@ Wiley Periodicals , Inc.
This mini review summarizes hypotheses and theories postulated in the literature regarding growth plate maturation and epiphyseal fusion.
This mini-review will focus on the role of hTERT in gene transcription regulation , and discuss its possible mechanisms.
This mini-review will present and discuss the current knowledge on the relationship between testosterone replacement therapy and change in lipid fractions in older men.
This misclassification may improperly inform dose-response relationships and population-based prevalence of physical activity in these and may extend to other clinically important populations.
This mismatch between the two levels may help explain the general emotional behavior impairment found in these patients.
This mitochondrial DNA protection might be conferred by an increased base excision repair activity.
This mitochondrial telomerase-mediated anti-aging may be a new target of moxibustion intervention for protecting cardiomyocytes from injury under exhaustive exercise condition.
This mitotic DNA synthesis , termed MiDAS , requires the MUS81-EME1 endonuclease and a non-catalytic subunit of the Pol-delta complex , POLD3.
This mixed-methods study aimed to identify couples ' preprostatectomy barriers to sexual recovery.
This model allows us to investigate the dynamics of cancer initiation and its dependence on the mutational fitness distribution.
This model also explains the relatively late onset of the disorder , at approximately age @number@
This model correctly classified @percent@ of successful and @percent@ of unsuccessful scans.
This model explained @percent@ of the variability in physical performance.
This model explains @percent@ of the variation in age , with a prediction error of @number@ years.
This model gave a mean absolute deviation of @number@ years for the training set and @number@.3years for the validation set.
This model had a c-statistic of @number@ in the validation sample.
This modeling approach was applied to evaluate β-cell lifespan in a rodent model of type @number@ diabetes in comparison with nondiabetic controls.
This model introduces four ideas : ( @number@ ) That Aβ is a synaptic signaling peptide that becomes toxic in circumstances of metabolic stress.
This model is a simple and noninvasive method for everyday clinical practice and follow-up.
This model is based on the concept of continuous adaptation to the environment of biosystems from the moment of its birth.
This model is based on the experimental results of previously published studies.
This model is presented not as a finished product but as a basis for future discussion and refinement.
This model is then validated against the large population-based prospective Maastricht Aging Study dataset.
This model may have a place in comparing products or treatment regimes , particularly when changes are subtle.
This model might be used to develop screening and prevention strategies.
This model of caregiver support can inform public policy in providing assistance to caregivers.
This model of emergency care may have unintended consequences for patients and the healthcare system.
This model of working was piloted in @number@ areas around the UK , commencing in @number@ as an Early Implementer site.
This model provides a structural mechanism for the processivity of telomerase and offers new insights into elongation.
This model provides a useful tool for studying the role of Aβ oligomers in AD pathogenesis.
This model results in a @percent@ reduction in nephron number rather than @percent@ , due to compensatory nephrogenesis in the remaining kidney.
This model showed a similar pattern of associations between suicidal ideation and personality across both groups.
This model showed that health status was correlated within sib-ships , suggesting a familial / genetic component.
This model shows that @percent@ of the variation in ovarian volume is due to age alone.
This model suggests that intervention in mitochondrial aging may be possible using appropriate NAD⁺ precursors such as nicotinamide riboside.
This model supports an initial role for Aβ oligomers in the onset of AD and suggests that Aβ plaques may not be the only prerequisite.
This model system opens up an exciting and new area of study of renal development and diseases.
This model was analyzed as a parallel process model.
This model was applied to proteins with known structures in the PDB database.
This model was compared to the amount of glucose provided with @percent@ or @percent@ dextrose-based saline solutions infused at fluid maintenance rate.
This model was effective for improving osteoporosis risk assessment , diagnosis , and treatment in a community setting.
This model was predictive for different probabilities of failure , suboptimal or optimal outcomes.
This modification blocks the anti-senescence activity of SIRT1 and plays a critical role in the loss-of-SIRT1 function during vascular ageing.
This modification results in loss of peptidyl-prolyl isomerase activity.
This modulation leads to a reduced availability of anandamide in Alzheimer's disease and to an increased availability of this endocannabinoid in aging.
This morbidity impacts on the relatively high mortality levels and has disabling effects.
This more or less reflects an \ "engine running out of fuel. \ "
This more recent research has highlighted that a range of illness-specific , neurodegenerative and vascular factors appear to contribute to the various phenotypic presentations.
This morphological indicator may have useful diagnostic and prognostic significance.
This morphological plasticity is controlled by fission and opposing fusion events.
This motif is essential for PCNA binding and co-localization during S-phase.
This motivates further study of proxy assessments that could be used earlier in critical illness to assess premorbid functional status.
This motor phenomenon may provide insight into the underlying mechanisms and kinetic characteristics of voluntary and involuntary motor control in various populations.
This mouse improves the design and phenotype of currently available optineurin mice , which showed high global overexpression.
This mouse line is suitable for studying brain senescence because brain atrophy and cognitive dysfunction are observed with aging , similar to humans.
This movement had been further divided into @number@ phases ( braking , mid-stance , swing , and terminal loading ) for analysis.
This MR-based prediction model has not yet been used to assess ligament degeneration in the aging human knee.
This multi-center , double-blind , and placebo controlled study enrolled @number@ elderly volunteers who were randomly assigned to receive either placebo or probiotics.
This multi-domain study is structured in two phases.
This multifaceted nutritional problem requires implementation of multicomponent interventions.
This multigenerational , hermeneutic study began @number@ years ago when @number@ families were interviewed after the teen's infant reached @number@ to @number@ months of age.
This multi-marker approach was then validated across species and tissue.
This multi-method paper provides insight on the effect of OP on patients ' physical function and everyday activity.
This multistep process is extensively regulated at several levels , including post-translationally through the action of conserved longevity factors such as the nutrient sensor TOR.
This multitasking protein is involved in regulating different networks of cell signaling.
This must be considered in modelling of BF.
This mutant showed abnormal phenotypes of climbing ability and sleep , and short lifespan.
This mutation consists of three adenosine inserts , introducing nine amino acids , including two glutamines into the mutant protein , herein called CPE-QQ.
This mutation had been previously described in @number@ unrelated French patients with FTD-ALS.
This mutation leads to an amino acid change within the zinc finger domain and results in reduced DNA binding.
This mutation results in the deletion of @number@ amino acids at the carboxyl-terminal tail of prelamin A , and the truncated protein is called progerin.
This mutation was described to cause instability in the BANF1 protein , causing a disruption of the nuclear envelope structure.
This mutation was not reported in the @number@ Genome Project , dbSNP and Exome sequencing databases.
This mutation was predicted to be pathogenic by in silico analysis.
This mutation was previously described in @number@ sporadic cases but was never associated with familial cases.
This mutual neglect should end.
This narrative review considers the key challenges facing healthcare professionals and policymakers responsible for providing care to populations in relation to bone health.
This narrative review focuses on the clinical problems arising in older people with hemophilia , with particular attention to the optimal therapeutic strategies.
This narrative review focuses on the relationship between aging and sport participation , and the effect on both performance and recovery following an exercise bout.
This needs to be taken into account in efforts to improve health and retention of mental capital across the life course.
This needs to be taken into consideration when designing therapies aiming at reducing Aβ levels to treat Alzheimer disease.
This negative connectivity was reduced with age.
This negative effect was dose-dependently ( with a lower effect at 20µM ) and significantly counteracted by pretreatment with baicalein ( 50µM ) .
This negative relationship suggests that better quality of structural connections allows for more efficient use of task-related GM processing resources.
This network did not include the core ventral face-processing areas but involved the left inferior occipital gyrus , frontal , and parietal regions.
This network must respond to constant fluctuations in the amount of destabilized proteins caused by errors in protein synthesis and exposure to acute proteotoxic conditions.
This network was very similar , but less extended , during semantic AM retrieval.
This neural adaptation was greater in young than in older adults and was more pronounced when the same sound was repeated at the same location.
This neurodegenerative disease becomes more prevalent with aging , but predisposing genetic and environmental factors also contribute to increased risk.
This neuroimaging marker was related to higher cognition even in the presence of WMH and other cardiovascular conditions.
This new approach may provide a direct link between cochlear synaptopathy and perceptual difficulties.
This new concept of NAD World also conveys ideas of functional hierarchy and frailty for the induction of aging in mammals.
This new discovery of synaptic loss opens doors to new research directions.
This new \ "drug \ " and approach both merit further investigation in order to confirm their antiaging efficacy.
This new finding is entirely at odds with the old , and does not support our later work on humans.
This new finding might have relevance for the life expectancy in TS.
This newfound CsA-mediated neuroprotection pathway prompted research on its use to prevent cell death in stroke and other neurological conditions.
This new insight may have implications for evaluation of osteoporosis stage and susceptibility.
This new knowledge should pave the way for the development of novel therapies that target tissue-specific ageing mechanisms to treat vascular decline in CKD.
This newly-determined data was combined with earlier data , e.g. , 4-year mortality and medical history.
This new method of mapping potentially has a useful role in evidence synthesis and cross programme comparisons in studies using different measures.
This new metric variable corresponds to the dental prediction of the mandibular-form variation.
This new paradigm will require reform of NHI's operating system , funding , and spending.
This new practice paradigm will promote a closer integration with the larger health care system.
This new sequencing technology is useful for detecting genetic variations in familial AD.
This new situation requires a new multi-disciplinary approach bringing together different research programs in order to provide solutions for the upcoming challenges.
This new technology provides significant clinical improvement with high patient satisfaction.
This new understanding will promote clinical applications in drug discovery and personalized therapy.
This New York City cross-sectional study of aging HIV-positive gay and bisexual men assessed their neuropsychological state.
This noninvasive FI based on clinical measures can be used in longitudinal studies to quantify frailty in mice.
This non-invasive method for the determination of phase response curves of coupled oscillators may find application in many scientific disciplines.
This non-invasive novel fractional NIMNRF approach provides safe and effective treatment of skin tightening in Asian patients.
This non-invasive therapeutic strategy brings patient satisfaction through a global approach to facial aging.
This nonpharmacologic approach should be considered part of the clinical management of dementia.
This non-systematic review of intentional non-adherence to medication highlights the extent of the problem amongst older adults.
This normalcy-pathology homology is critical to understand , since aging itself is the major risk factor for sporadic AD.
This normal exercise-induced reduction in E ( A ) / E ( LV ) decreases with advancing age.
This normative data may be valuable in the diagnosis of neurodegenerative diseases.
This notion does not only apply to older workers.
This notion of common mechanisms gives rise to the converse postulate that diseases may be risk factors for accelerated aging.
This notion was based on the differential oxidation potentials of the isomers for the transformation of the hydroquinone to the active , electrophilic quinone species.
This novel approach focuses on the ability to remember sequences of events , an important feature of episodic memory.
This novel construct has several elements of novelty and may delineate a promising target for preventive and therapeutic actions against age-related conditions.
This novel epigenetic clock can be used to address a host of questions in developmental biology , cancer and aging research.
This novel finding connects inflammation found in aging prostate tissues with the altered epigenetic landscape.
This novel finding is important for the design of effective lifestyle interventions targeting older adults.
This novel finding may stimulate reinvestigation of folic acid supplementation as a prophylactic or therapeutic treatment for AD.
This novel interaction was replicable in an independent cohort.
This novel metabolite is present at a concentration of 10%-20% of the methylglyoxal level in the blood of insulin-starved patients.
This novel method may prove important in future therapy for combating osteoporosis.
This novel model is particularly suited to decipher the underlying mechanisms and to develop hopefully novel connective tissue-specific anti-aging strategies.
This novel multiplexed SRM assay should facilitate the study of the relationships of these proteoforms with major aging phenotypes.
This novel program , incorporating local organizations and using limited financial resources , resulted in swift behavior changes.
This novel signaling pathway will provide new platforms for regulation of mRNA translation via post-translational protein modification.
This novel technique requires human input only at a single step ; the allocation of the optic disk center.
This novel type of regulation affects not only multiple TASS isoforms , but also other alternative splicing classes , in a concerted manner.
This novel way of enhancing IL-10 was mediated by activating-type Fc receptors for IgG.
This novel work provides a foundation for understanding the underlying neural bases for differences in food acceptability between age groups.
This number exceeds the number of colorectal cancers diagnosed in @number@ by @percent@.
This number is expected to rise to @number@ by @number@
This number was reduced to @number@ when broad-spectrum nucleases were added to the lysate.
This number was smaller than that of the full model ( @number@ ) and the model with baseline cognitive function ( @number@ ) .
This objective result correlated well with the periorbital wrinkle classification result of @percent@.
This observational cohort study included @number@ women with unexplained infertility and normal or low ovarian reserve.
This observational , comparative study assessed psychosocial functioning in @number@ euthymic older adults with bipolar disorder compared with @number@ healthy controls.
This observational ethnographic study was conducted with @number@ elderly people assisted by the Family Health Strategy.
This observational study aimed to establishing a relationship between lipid peroxidation and endometriosis in women undergoing controlled ovarian hyperstimulation.
This observation has important implications for patients undergoing genetic testing for C9orf72.
This observation has led to studies of muscle function in HFpEF revealing structural , biomechanical , and metabolic changes.
This observation is important when considering animal models of aging.
This observation is in line with experimental data demonstrating the osteogenic characteristics of calcified arteries.
This observation is in line with the results of the Wnt16 ( - / - ) mice.
This observation is particularly true in the aging male and is exacerbated by inconsistencies between different laboratory assays.
This observation is possibly related to a reduction in beta-APP expression in the rat brain.
This observation is present in both cross-sectional and longitudinal analyses , in diverse patient populations , and after controlling for a variety of potential confounders.
This observation is reinforced by zeta-potential and fluorescence spectroscopy measurements.
This observation may be related to the number of hours practicing dance , which differs between groups.
This observation opens a potential window of opportunity to treat spinal deformities by mechanical GM.
This observation raises the issue of the relation between the psychiatric pathological process and the peripheral telomere marker.
This observation reflects the importance of timing in restoration of ovarian influence in this study.
This observation should be confirmed in future clinical trials of yoga intervention for treatment and prevention of cognitive decline ( NCT01983930 ) .
This observation suggests that the LAF reflex loop may be critical to the control of balance in those individuals suffering from small-fiber PN.
This observation was confirmed in unpaired analyses , where DNAmAge initially correlated with cognitive abilities , until adjusting for chronological age.
This observed SIRT1 induction was associated with decreased cyclin D1 protein , increased cyclin-dependent kinase inhibitor p21 protein expression , and induced apoptosis.
This occurred at a time following a prolonged period of drought and , in central Victoria , a complete ban on outside watering.
This occurred concurrently with an increase in gene expression with age.
This occurred despite the fact that other primary subjective stressors , such as role captivity and role overload , were not reduced.
This occurred during normal ageing and without microglia dystrophy or changes in cell density.
This occurred even when grandparents had previously been highly involved in the lives of their grandchildren.
This occurs at multiple levels in an organism-for example , between organelles or between tissues.
This occurs especially when surgical implants must be fixed to bone , as it occurs when lumbar fusion is performed with pedicle screws.
This occurs mainly through the blockade of adenosine A2A receptors , whose expression and function become aberrant throughout aging and in age-related pathologies.
This occurs via a hypothalamic neuronal network that provides the necessary input to the SCN.
This offers an understanding of the tremendous health impact of DNA damage derived from environmental and endogenous sources.
This offers some guidance to health professionals in advising patients on MMD choice however , overall MMD rating appears dominated by transportability.
This OMNIBUS repeated-measures ANOVA was then followed up with separate repeated-measures ANOVAS for the initial , middle , and final positions.
This one , as a component of long-term memory is the memory of words , ideas , concepts.
This opens up the possibility for systematic comparisons of metabolites in the medial wall of the brain.
This option gives residents access to care in their residence.
This outcome may suggest a way of prevention of complete fractures in symptomatic patients with long-term treatment with bisphosphonates.
This overly optimistic definition was incepted in the 1970s amid the public's fear of the upcoming SD crisis and desperate hope for a cure.
This overview discusses the current data and highlights the importance of further studies to evaluate the impact of skin factors in age-related percutaneous penetration.
This oxidative stress can subsequently exert downstream effects and the subcellular compartments most affected by this oxidative stress are mitochondria.
This p53-mediated repression of GMPS could be validated by immunoblotting in Sk-Hep1 , HepG2 , and HuH6 cells.
This paper addresses ageing and embodiment and explores how age is negotiated in interaction using Membership Categorisation Work.
This paper addresses how different statistical techniques compare the prevalence of age-related skeletal indicators , specifically osteoarthritis.
This paper aimed to develop a rat clinical FI.
This paper aimed to propose and test an operational definition of cognitive frailty.
This paper aimed to review the limited , but growing literature on prospective memory ( PM ) following closed head injury ( CHI ) .
This paper aims to advance long-term care practice and , to that end , examines the application of modularity.
This paper aims to analyse the reasons for failure of surgery for degenerative disease of the lumbar spine.
This paper aims to describe the progress toward UHC in the ASEAN countries and discuss how regional integration could influence UHC.
This paper aims to describe the use of smartphones by health professionals and patients in the field of health promotion.
This paper aims to discuss the effect of ginkgo aglucone flavone to human body organs and immune function.
This paper aims to highlight some of the important issues presented to the elderly undergoing surgery and to suggest some strategies for management.
This paper aims to review articles related to facial fillers in the periorbital area , forehead , and temple.
This paper aims to review the state of knowledge on the biomolecular relationship between cellular senescence , ageing and cancer.
This paper analyses effectiveness of a culturally tailored community-based lifestyle modification program ( Sydney Diabetes Prevention Program ( SDPP ) ) targeting Mandarin speakers.
This paper analyses variables associated with community-dwelling older people's engagement in physical activity ( PA ) .
This paper analyzes its conceptual framework , measurement mode , psychometric properties , and merits and problems.
This paper analyzes the components that will differentiate orthopaedic care provision for the Second Curve.
This paper analyzes the impact of population aging on health care expenditures in Korea.
This paper argues that assisted reproduction treatment has had a damaging social impact.
This paper assesses the determinants of DM medication use and catastrophic expenditure on medications in older adults with DM in China and India.
This paper briefly reviews the literature to discuss the role of intracellular compartmentalization in the regulation of skeletal muscle glycogen metabolism and insulin signalling.
This paper comes at the end of a string of other studies that are calling into question the free-radical damage theory of ageing.
This paper considers the history and pharmacology of this neurotoxin , and focusses on the literature concerning the treatment of different facial areas with BoNTA.
This paper considers the problem of indoor tanning bed use by teenagers.
This paper deals with corneal higher order aberrations in healthy humans and evaluates their changes with aging and corneal curvature.
This paper deals with the relationship of age with serum phosphorus and with the possible influences of this relationship on hyperphosphatemia secondary to kidney dysfunction.
This paper describes a case-control study and a meta-analysis conducted to derive a more precise estimation of the association between CETP 405V and longevity.
This paper describes a complex and emblematic case.
This paper describes a large-scale , systematic study investigating the prevalence of psychiatric illness in a Dutch adult PWS cohort.
This paper describes a qualitative study based on a series of key informant group interviews with an Aboriginal Grandmothers Group in the province of Saskatchewan.
This paper describes a qualitative technology development study to evaluate heuristics for recognition of undetected vision loss in older patients in primary care.
This paper describes a review on the effect of in-home comprehensive geriatric assessment.
This paper describes current biogerontology research in Finland especially in the universities with professorships in gerontology / geriatrics.
This paper describes recent studies that assessed the benefits of preventive strategies in the domain of dementia , especially in Alzheimer's disease.
This paper describes some novel spatial tasks and questionnaires designed to assess spatial and orientation abilities.
This paper describes some ways patients talk about their transitional experiences.
This paper describes the design of a healthful diet intervention on inflammageing and its consequences in the elderly.
This paper describes the development , implementation and evaluation of a learning innovation for pre-RN students.
This paper describes the major study contributions to the literature on AD and dementia.
This paper describes the potential of new food product development to facilitate dietary modification and address health deficiencies in older adults.
This paper describes the results of a literature search which sought papers specifically on appreciative inquiry ( AI ) and older people.
This paper describes the study protocol.
This paper details a study on ethnic identity in midlife , illuminating identity formation as a complex life course phenomenon.
This paper discusses the case of a young boy who died suddenly during a football match.
This paper discusses the role of DM in HF patients and underscores the potential need for the development of targeted therapies.
This paper establishes the sources of health disparities for Hispanics with HIV compared to a match group of Non-Hispanics with HIV.
This paper estimates the population of adults aging with early-onset disabilities at 12-15 million persons.
This paper examined the effectiveness of rTMS on first episode depressed patients when combined with antidepressant drugs.
This paper examines late life suicidal behavior within the context of lifespan developmental theory.
This paper examines older adult perceptions regarding various factors impacting longevity , including genetics , lifestyle , and the environment.
This paper examines the civil detention of older adults in one Scottish region under successive mental health legislation.
This paper examines the global issues of family caregiving for older persons with dementia from an Asian perspective.
This paper examines the implementation of the training programs and the challenge of integrating program graduates in the healthcare services.
This paper examines three possible justifications for original ACMG recommendations to return incidental findings from whole exome or genome sequencing independent of patient preferences.
This paper examines whether age-related and comorbid disease-related immune deregulation is an etiologic contributor to geriatric depression.
This paper examines whether maternity leave policies have an effect on women's mental health in older age.
This paper explored deeper themes hidden behind a discourse about barriers and facilitators to improving care.
This paper explores a patient appropriate for level-3 care with brain hemorrhage and paralysis of the left half of the body.
This paper explores discrepancies in OAS uptake using Canadian Census data from @number@ to @number@
This paper explores how disabled adults and older people find and use information to help make choices about services.
This paper explores how popular newspapers and magazines in Canada construct and portray later life sexuality within the context of online dating.
This paper explores rural carers ' experiences of accessing care from a range of services for older people with mental health problems.
This paper explores some common challenges currently faced by professionals providing palliative care for patients with either cancer or dementia across five countries.
This paper explores the association between different definitions of EM and their subtypes and suicidal ideation ( SI ) in an U.S. Chinese aging population.
This paper explores the idea of the ' fourth age ' as a form of social imaginary.
This paper explores the role of the nurse in empowering older people at all stages in the disaster cycle.
This paper explores the spatial distribution of the longevity population in a typical Chinese longevity region.
This paper explores the suggestion that older people would be less tolerant to shift work.
This paper explores the use of partial least squares ( PLS ) analysis to understand the interaction between overtime measures of functional decline.
This paper explores what values are at stake when a society ages.
This paper explores whether educational attainment has a cognitive reserve capacity in elder life.
This paper focuses on an architecture competition for the silver generation , namely those aged @number@ years and older.
This paper focuses on the emotional health of PSWs working in the home and community care sector in Ontario , Canada.
This paper focuses on whether and how health gains in economic evaluation should be differentially weighted by age of recipient.
This paper follows a statistical inference approach and presents a framework for prediction of future observations based on past measurements and population statistics.
This paper highlights implications for the governance of health systems using current debates on the evolution of these major fields of science.
This paper highlights several aspects of nutrition that require additional basic science and clinical application research to improve the health and well-being of older adults.
This paper identifies and systematically classifies the prevailing pharmaceutical policies worldwide in relation to a country's income status.
This paper illustrates how the achievement of each of the @number@ SDGs can be facilitated by the use of assistive products.
This paper interrogates this assumption through a conversation analysis of British naturalistic memory clinic interaction.
This paper investigates human and machine performance for recognizing / verifying disguised faces.
This paper investigates the relationship between the concept of activity ( including both professional and nonprofessional ) and cognitive functioning among older European individuals.
This paper is aim to examine the joint association of obesity and hypertension with risk of disability.
This paper is an appeal for increased debate about sonic representations of aged women , ageing and Alzheimer's disease and dementia in film.
This paper is an integrative review analyzing the scientific production and legal documents regarding public policies for the elderly in Brazil.
This paper is a review of the state of the art and a multidisciplinary guideline on strategies to improve the therapeutic index in this situation.
This paper is a short literature review of the relation between oxidation stress and age-related cataract.
This paper is a translated and adjusted version based on a publication in Journal of Clinical Epidemiology , @number@ ( @number@ ) 1121-1130.
This paper is based on an ethnographic fieldwork aimed at exploring ethnographically how vulnerability in old age is perceived and experienced in contemporary Denmark.
This paper is the first to rigorously study CCRCs on a national scale and the only study that focuses on nursing home quality.
This paper outlines a further study whereby consumers were asked to apply the most common grips to a specially designed torque measuring device.
This paper outlines a selection of scientific works published between @date@ and @date@ or presented as communications at the IID Meeting.
This paper outlines the consensus statement of a group of Italian experts on HZ.
This paper overviews the nationwide cancer statistics , including incidence , mortality , and survival rates , and their trends in Korea.
This paper presents a case study exploring an older woman's perspective on the quality of her life with dementia.
This paper presents a case study of a conventional radiology workflow analysis in a Portuguese healthcare provider.
This paper presents a comparative evaluation of methods for automated voxel-based spatial mapping in diffusion tensor imaging studies.
This paper presents a critical review of articles drawn from this literature to identify current directions leading the development of empirical research in this field.
This paper presents a discussion of knowledge and awareness regarding prevention of functional decline in older hospitalized patients.
This paper presents a method for detecting microdots using a two-step filtering scheme that separates the keratocyte cells and the microdots.
This paper presents a methodology for analysis of such 4D images , with brain aging as the primary application.
This paper presents a method that determines a Paediatric Bone Index automatically from such radiographs.
This paper presents a new corpus of @number@ high quality colour images belonging to @number@ subcategories and covering a range of naming difficulty.
This paper presents a new two-sex learning- and skills-based theory for the evolution of human menopause.
This paper presents an exploration of client engagement practices within a large aged care service provider in Australia.
This paper presents IATs that are currently in development in the research community to support tasks that can be impacted by compromised cognition.
This paper presents new KCT formulations and a fast heuristic approach to efficiently solve the KCT models for large DMN regions.
This paper presents the database and its research potential.
This paper presents the design and development of a novel , textile-based , intelligent wearable vest for real-time posture monitoring and emergency warnings.
This paper presents the design , development and hydrodynamic assessment of a novel bi-leaflet mitral valve suitable for transcatheter implantation.
This paper presents the findings of a study that explored client engagement practice within a large Australian service provider.
This paper presents the first mechanism-based model spanning full individual life and capturing changes in body weight , composition and height.
This paper presents the preliminary experiments with such a system.
This paper presents the preliminary results of a study aiming to elicit these needs.
This paper presents the use of the ensemble empirical mode decomposition ( EEMD ) algorithm to aid in the extraction of the desired respiration signal.
This paper presents , to the best of our knowledge , the first attempt towards automatic tongue muscle segmentation from MR images.
This paper primarily focuses on the impact of stilbenoids in Alzheimer's disease and more specifically on the inhibition of β-amyloid peptide aggregation.
This paper projects the effects of future changes in population , coverage , claims rates and average claims cost on GMS costs in Ireland.
This paper proposes a framework which uses mobile phone technology together with physiological data monitoring in order to detect falls.
This paper proposes an Infinitesimally ratcheted random walk as a way to solve that problem.
This paper proposes a novel index by substitution blood pressure with amplitudes of pressure pulse.
This paper provides a narrative exploration of the value of death conversations in the clinical context in New Zealand.
This paper provides an inventory and content analysis of definitions of social participation in older adults.
This paper provides an overview of current research into potential structure-modifying drugs and more appropriately targeted pharmacological therapy.
This paper provides an overview of the Saguenay Youth Study ( SYS ) and its parental arm.
This paper provides a review of the current literature regarding the psychological aspects of pre-hospital cardiac arrest in children.
This paper provides a systematic review of current research findings using exergaming as a treatment for improving cognition and dual-task function in older adults.
This paper provides a systematic review of the published literature on invasive and noninvasive methods used to quantify lifetime UV exposure ( 'photoageing' ) .
This paper provides conceptual and operational guidance for these early stages of scope formulation to assist authors of systematic reviews of complex interventions.
This paper provides highlights from a CDC-hosted meeting on opportunities for cancer prevention during midlife ( roughly ages 45-64 years ) .
This paper reflects on the significance of PCCMCs within the system of care for older adults , supported with data from ongoing evaluation studies.
This paper reports on one case in which medication was not and could not be used because the symptoms were too severe.
This paper reports the application in a clinical setting of the European Test of Olfactory Capabilities ( ETOC ) , combining odor detection and identification.
This paper reports the diagnostic accuracy of HARP for downstream quality of life.
This paper reports the growth and degenerative pattern of human spine using principal component analysis.
This paper represents a summary of the discussions.
This paper represents data of long-term open prospective study.
This paper reviews apparent diffusion coefficient ( ADC ) values of the CPs for age-related changes.
This paper reviews brain Aβ- and FDG-PET studies in AD patients as well as in non-demented individuals at risk for AD.
This paper reviews existing data on racial and ethnic disparities in use of and quality of palliative care and outlines priorities for future research.
This paper reviews federal policy changes since @number@ that have expanded and enhanced services for informal caregivers.
This paper reviews how HIV / AIDS and its therapy cause premature aging or contribute mechanistically to HIV-associated non-AIDS illnesses ( HANA ) .
This paper reviews recent advances in the study of two major dietary phytochemicals , resveratrol and curcumin , on aging and stress response.
This paper reviews recent evidence from magnetic resonance imaging ( MRI ) studies about age-related changes in the brain.
This paper reviews some of the most common injectable aesthetic treatments with an emphasis on dental-related applications.
This paper reviews the complexity of NCDs intertwined with ageing.
This paper reviews the development of the auditory P300 across the lifespan.
This paper reviews the evidence of impairment in everyday functioning and in working , long-term and prospective memory in early dementia.
This paper reviews the evidence with regard to the specific challenges encountered by older nurses in the workplace.
This paper reviews the literature on senile pruritus , in order to improve understanding of this condition and to enable improved diagnosis and treatment.
This paper reviews the modern concept of age-related androgen deficiency.
This paper reviews the pathophysiology of type @number@ diabetes among older adults and the implications for hyperglycemia management in this population.
This paper reviews these three studies with respect to the brain attributes studied , the analytical strategies applied , and the findings revealed.
This paper reviews the use of descriptive statistics to describe the participants included in a study.
This paper seeks to determine whether the non-replication in this AREDS sample may be due to the limited number of SNPs chosen for replication.
This paper shifts the focus to older adults ' tendencies to cultivate new social ties.
This paper shows the relevance and the complexity of this problem and shows that patients at risk can be recognized by four simple questions.
This paper starts from a care ethical perspective on care and reports on a phenomenological study into older patients ' experiences of hospitalisation.
This paper stops on several of them , namely theory of mind , empathy , moral reasoning , emotional processing and emotional regulation.
This paper studied the resin purification process optimization conditions and antihypertensive effect of Eucommia ulmoides Oliver.
This paper studies the procedural learning of semantic categorization in @number@ patients with non-demented Parkinson's disease ( PD ) .
This paper suggests a possible solution to an apparently unsolvable problem : reconceptualizing adherence.
This paper suggests a role for friends and professionals in addressing this neglected issue.
This paper summarizes a century of scientific exploration on the ( patho ) physiological role of carnosine and related compounds.
This paper summarizes past trends and projections in fertility and population.
This paper therefore investigates the influence of overweight across the life course on levels of these markers at retirement age.
This paper thoroughly describes the steps involved in preparing saponin-skinned cardiac fibers for oxygen consumption measurements to evaluate mitochondrial OXPHOS.
This paper uses a meta-analysis of comparable published data to plot trends in time by muscle , enthesis type and sex.
This paper will address cases of aging processes and facilities aside from modernizing options.
This paper will address issues specific to data acquisition , analysis , and interpretation for MEG developmental studies.
This paper will briefly summarize the burden of disease , HF classification and definitions and the landmark clinical trials in both HFrEF and HFpEF.
This paper will cover several hypotheses that attempt to account for age-related alterations among this cell population.
This paper will examine some of the innovative methods used to monitor age-related alterations of the neuromuscular system from sEMG signals.
This paper will provide nursing guidelines and rationale as well as a nursing protocol for the management of patients who undergo UGTI for FPA.
This paper will review key elements that have to be taken into account in the context of proteomic-based biomarker discovery applied to blood banking.
This paper will review the effects of upper facial aging and emphasize patient evaluation , surgical techniques and complications of upper blepharoplasty.
This paradigm has started to shift dramatically , primarily because hallmarks of aged HSCs have been successfully reverted by distinct experimental approaches by multiple laboratories.
This paradigm has stood for more than @number@ years but has yet to be tested objectively with quantitative data.
This paradoxical association was mediated in part by muscle size.
This paradox is even more striking in people with schizophrenia.
This parallels the ongoing nursing shortage , as lack of faculty limits nursing student capacity.
This parameter is termed the regional ( @number@ ) F-FDG time correlation coefficient ( rFTC ) .
This parameter may be determined as a marker of individual radiosensitivity and probability of developing cancer.
This partial rebalancing seems to be mainly related to a reduction in proinflammatory adipocytokines , rather than an increase in anti-inflammatory adipocytokines.
This particular article reviews the three workshops held under the \ "Functional Extracellular Matrix \ " stream.
This particular profile of abnormalities may be associated with seizure-mediated compromises in brain maturation early in development.
This particular protective effect of tiron was greater than a range of cellular antioxidants investigated.
This particular review focuses on the cheek and neck.
This particular surgical technique has shown the advantage of being minimally invasive and effective.
This passages of this discussion are related tot he VIIth book of the Metamorphoses.
This passive acceptance may be unnecessarily exposing older people to disability and serious co-morbidity.
This passive control mechanism allows the infant to remain upright so that active feedback control mechanisms can develop.
This paternal effect is proposed to be an adaptive signal of the expected age of male reproduction in the environment offspring are born into.
This pathology can be prevented by inhibition of mTORC1 or by induction of autophagy.
This pathology during which chondrocytes undergo modifications of their phenotype may result from alteration of transforming growth factor β ( TGFβ ) signaling.
This pathway is highly conserved and the most studied among different organisms.
This pathway provides a unified mechanism by which metformin kills cancer cells and extends lifespan , and illuminates potential cancer targets.
This pathway serves to degrade nonfunctional or unnecessary organelles and aggregate-prone and oxidized proteins to produce substrates for energy production and biosynthesis.
This pathway together with mammalian target of rapamycin ( mTOR ) will be reviewed as being the most promising for longevity.
This patient population contains an increasing number of adults.
This patient required supportive and adaptive devices , a cane for walking , and constant observation.
This patient's treatment is further complicated by poor renal function , medications with potential interactions , and a recent diagnosis of depression.
This patient suggests that there may be a certain infectious agent causing URI , leading to the co-occurrence of FS and ITP.
This pattern held even when socioeconomic status , social networks , and prior health were adjusted.
This pattern links improvement of performance-monitoring capacity to age-related increases in posterior MFC and decreases in anterior MFC activation.
This pattern of ARHL is similar to that of most humans : difficult to diagnose clinically at its onset and currently not treatable medically.
This pattern of brain activation is consistent with the attentional gradient model or bottom-up accounts of ILM in preference to impletion.
This pattern of diffusion abnormalities is also associated with clinical disease severity.
This pattern of findings helps clarify why many older people may be able to maintain their subjective well-being , while their cognitive abilities decline.
This pattern of findings suggests that MCI is associated with specific inhibition problems.ty.
This pattern of gene by environment interactions was consistent with differential susceptibility or the flip-flop phenomenon.
This pattern of MRS abnormalities may have a role in differential diagnosis of DLB and in distinguishing DLB patients with overlapping AD pathology.
This pattern of regional associations remained essentially unchanged-although less spatially extended-when grey matter volume or 11C-PiB uptake maps were added as covariates.
This pattern of results is discussed in relation to mechanisms that may contribute to declines in facial perceptual processing in older adulthood.
This pattern of results is exhibited by the greater part of the children.
This pattern of results suggests that the impairment in picture naming exhibited by MCI individuals is due to an inefficient semantic access.
This pattern of results was true for listeners of both ages although younger listeners had smaller thresholds overall.
This pattern of vulnerability corresponds to enhanced accumulation of senile plaques in the superficial cortical layers with aging and Alzheimer's disease.
This pattern recognition will further activate the adequate response.
This pattern remained after adjusting for lifetime history of drinking and recent drinking.
This pattern remains rather stable after including methylomes of two white individuals.
This pattern suggests an age-related decrease in the efficiency of parsing and interpretation.
This pattern suggests disproportionate impairments of neural processing among older individuals carrying disadvantageous genotypes.
This pattern was characterized by significant FA increase accompanied by reduction in RD , Trace without significant AD changes.
This pattern was maintained regardless of the clinical cutoff employed ( > @number@ or > @number@ ) .
This pattern was more noticeable in the three hearing-impaired groups than in the normal hearing group.
This pattern was observed in all BMI levels.
This pattern was reversed for activities that were low in demand.
This pecuniary trade-off , revealed by our study , can have strong implications for the well-being of the elderly and their relatives.
This penultimate aim will be achieved by our @number@ main goals.
This percentage includes all-cause rehospitalizations.
This percentage was the highest for lung cancer ( @percent@ ) and the lowest for colon cancer ( @percent@ ) .
This perceptual narrowing occurs at the expense of the ability to process non-native phonemes.
This \ "perfect storm \ " provides the opportunity for the social work paradigm to come in and fill the void.
This performance might be related to the preservation of some movement timing properties and relationships between the agonist and the antagonist neuromuscular systems.
This period of life appears to spot a decline in a series of skin functional performances initiating tissue atrophy , withering , and slackness.
This permanent growth arrest is called cellular senescence.
This permits smaller sample sizes without loss of power , among other utilities.
This permits study of the vascular network in three dimensions , and the differentiation of afferent from efferent vessels.
This persisted after adjusting for the severity of dementia.
This persisted after adjustment for confounding factors.
This perspective article identifies barriers individuals with selected LLDs experience in accessing health care , including physical therapy.
This perspective brings together the different avenues of investigation implicating the role that metabolism may play within the context of post-genomic concepts of cancer.
This perspective describes how the proton gradient is formed.
This perspective paper outlines pros and cons of the use of statins in neurodegenerative disorders , with particular emphasis on Alzheimer disease.
This phenomenological study aimed to identify and describe the general meaning structure of the experience of well-being after retirement.
This phenomenon , added to population aging , will inflate the cancer prevalence.
This phenomenon compromises the host's ability to defend against alphavirus infection and pathogenesis.
This phenomenon could reflect subtle changes in frontal lobe integrity.
This phenomenon has not been thoroughly described in Portugal.
This phenomenon implies several medical , economic and social problems because of dramatic increase in number of non autonomous individuals affected by various pathologies.
This phenomenon is hypothesized to lead to increased production of hydrogen peroxide and reactive oxygen species ( ROS ) , thereby contributing to AD pathology.
This phenomenon is known as bilateral deficit.
This phenomenon is known as sarcopenia and affects about @percent@ of the over 60-year-old population.
This phenomenon is known as the action compatibility effect ( ACE ) .
This phenomenon is likely a candidate for a neural substrate of cognitive reserve.
This phenomenon is linked to an imbalance between neoformation ( by osteoblasts ) and resorption ( by osteoclasts ) .
This phenomenon is not seen in delayed cases.
This phenomenon is rarely explored among middle-aged offspring and their aging parents.
This phenomenon participates in cell and tissue aging and is therefore involved in the aging of human organism.
This phenomenon remains true for lagged hourly temperature measures and the changing patterns of associations from January through December are revealed.
This phenomenon results from oxidative stress , with NO \ "scavenging \ " and dysfunction of soluble guanylate cyclase ( sGC ) .
This phenomenon , termed \ "inflammaging \ " is also a risk factor for both morbidity and mortality in the elderly.
This phenomenon , termed selfish spermatogonial selection , is likely to occur in all men.
This phenomenon was also confirmed by pretreating the rGO surfaces with a blocking agent and subsequently subjecting them to antibody immobilization.
This phenotype is associated with new-onset chronic health conditions and mortality among both older adults and childhood cancer survivors.
This phenotype is preceded by early deficits in dopamine release from terminals in the dorsal , but not ventral , striatum.
This phenotype underlines the increasing trend of early-onset vascular aging among black populations.
This phenotype was noted in only @number@ of the @number@ investigated non-CD-associated carcinomas.
This phenotype was only partially abrogated by concomitant loss of p53 in the germline.
This phospholipid is associated with membranes which are designed to generate an electrochemical gradient that is used to produce ATP.
This phototoxic spectrum may be advantageously valued in designing selective photoprotection ophthalmic filters , without disrupting essential visual and non-visual functions of the eye.
This physiological change could significantly contribute to the onset of schizophrenia and the worsening of autistic behaviors , both typically occurring at puberty.
This phytogeographic zone stands out in its climatic conditions and biodiversity.
This picture was found neither in H63D non-carrier patients , nor in healthy controls.
This pigment is a light-induced isomer of isoA2E , rather than A2E , referred to as iisoA2E.
This pilot randomized controlled trial recruited @number@ older adults aged @number@ or above who did not engage in any social activity.
This pilot study aimed to investigate the possibility of visualizing the hand aging process by 3D stereophotogrammetry.
This pilot study aimed to test the effectiveness of a structured telephonic counselling ( STC ) on exclusive breastfeeding ( EB ) on healthy babies.
This pilot study determined the effects of RT with and without CR on arterial stiffness in overweight and obese older adults.
This pilot study examined changes in physical activity and function among older adults moving from community dwellings to retirement living.
This pilot study is based on the ColoCare Study , a cohort study of newly diagnosed patients with stage I-IV colorectal cancer.
This pilot study juxtaposed life review within regular PTSD group counseling for @number@ Vietnam veterans at a community-based Vet Center using a partial crossover design.
This pilot study tests the feasibility and acceptability of delivering this intervention to older adults.
This pilot tested the instrument with an exclusively lesbian population in the Midwest.
This placement reaction required physical contacts of Cdc45 with the RPA70A subdomain.
This places a large burden on countries ' health and long-term care systems.
This places pressure on the patient , their family , and on health care resources.
This plan is in conjunction with developing new ways of working incorporating the Healthy Child Programme.
This point is defined by structural disruptions of the extracellular matrix ( ECM ) .
This policy option , however , poses various challenges and may also threaten the quality of life of the aging.
This polymorphism also seems to be associated with longer lifespan , but no information on telomere length ( TL ) is available.
This polymorphism is known to influence a variety of physiological adaptions to exercise.
This polymorphism resides in an active regulatory region marked by H3K27Ac and DNase I hypersensitive site and is an eQTL for CLU expression.
This poor-quality sleep is challenging for caregivers and frequently results in admitting older adults to long-term care institutions.
This population-based cohort study presents the changing rate and causative factors of laparoscopic cholecystectomy in Finland during the era of statin use.
This population-based study documented changes in workload and treatment complexity over a @number@ year period in a Canadian province.
This population had been enrolled in a national study of the genetic determinants of health status.
This population poses unique medical and social challenges to the multidisciplinary team that provides care.
This population received a questionnaire in the mail focused on factors contributing to their cessation of resistance training exercise.
This poses a major care challenge care , with more fragile patients and new needs.
This position paper of a Task Force of the International Society of Geriatric Oncology ( SIOG ) reviews currently available evidence relevant to such patients.
This Position Paper summarises the main outcomes of this international effort to provide the STandards for ReportIng Vascular changes on nEuroimaging ( STRIVE ) .
This positive association was no longer apparent after adjusting for age.
This possibility leads to a rather different view on the biological variation of function in the brain of older individuals.
This post hoc analysis evaluated the safety , tolerability , and effectiveness of oxycodone DETERx among patients ≥65 years of age.
This post-movement β amplitude was significantly reduced in older subjects.
This post-translational modification adds a tripeptide and a net negative charge that can lead to distinct structural and functional changes in the target protein.
This postulate emphasizes prevention or reversal of emerging neurocognitive pathology considerably before AD onset.
This posture may lead to bladder dysfunction.
This potential role is examined in four focus groups with @number@ nursing home residents in Flanders ( Belgium ) .
This potential role is examined in four focus groups with @number@ nursing home residents in Flanders ( Belgium ) .
This potential structural heterogeneity of longer disease-relevant repeats should therefore be taken into account when studying their role in disease pathogenesis.
This practice had a positive result , producing changes in the quality of life of the elderly , particularly in the psychological domain.
This practice is based on the assumption that a higher wave speed indicates vascular stiffening.
This practice suggests an implicit assumption that patients who appear older than their actual age are more likely to be in poor health.
This precision is higher than age predictions based on telomere length.
This precludes phosphorylation of nuclear lamin by the mitotic kinase , a prerequisite for disassembly of the nuclear membrane.
This predictive capacity was further compared with the capacity of @number@ well-established frailty models ( the frailty phenotype and the Frailty Index ) .
This predicts that induction of p53 will not cause senescence in such quiescent cells.
This preference remained even after the dilution of abobotulinumtoxinA was decreased.
This preliminary investigation examined the effects of vocal function exercises , a physiologic voice therapy approach , as a primary treatment for presbylaryngis.
This preliminary MALDI-MSI study raised some technical difficulties that were overcome.
This preliminary study examined the effects of hearing loss and aging on the detection of AV asynchrony in hearing-impaired listeners with cochlear implants.
This preliminary study on the traditional Sardinian diet has been supported by the literature available , which has been carefully reviewed and compared.
This preparation can extend to any medical or surgical treatment for aging skin.
This preparation led to a recruitment of @number@ participants ( @percent@ ) and to high participation rates in key parts of the assessment.
This preparation might be cautiously applied for patients in regular clinical conditions referred for elective endoscopy.
This pre-rigor temperature controlled chilling is a realistic alternative for the beef industry in China to ensure adequate tenderness and shorten aging time.
This presentation provided scientific results and rationale for the use of intranasal oxytocin for the treatment of migraine headache.
This presents challenges for MMSE scoring in research settings.
This primary injury is thought to be irreversible and resistant to most treatments.
This probably reflects the aging of existing HBV carriers and the effective prevention measures restricting new HBV infections.
This probably reflects the general deterioration of physical abilities , such as lowered cognitive and somatic performances.
This problem is rooted in a blunted hormonal responsiveness of the ageing uterus.
This procedure aims to improve the appearance of the lower two thirds of the face and neck.
This procedure allowed comparing the tracing performance of all groups ( with the same amount of practice ) in a standing condition.
This procedure can be performed for various age groups to rejuvenate and reshape the middle face.
This procedure , however , does not always confer the same benefit of single transplants from young donors.
This procedure releases postural reflexes possessing higher frequencies and lower amplitude range.
This procedure was used for @number@ patients from @date@ to @date@ .
This process can be studied at several levels of abstraction , in different organisms and with different objectives in mind.
This process can be time consuming.
This process causes appropriate microarchitectural changes tending to adjust and improve the bone structure to its prevailing mechanical environment.
This process consists of a variety of well-orchestrated phases and is mediated by many signals.
This process could remove a buffer that normally protects individuals against distress-related changes in cortisol secretion.
This process includes a loss of skeletal support , soft tissue volume depletion , and a decrease in skin elasticity.
This process initiates with programmed double-strand breaks that are repaired through the use of homologous chromosomes as a repair template.
This process is also promoted by two other PD-lined genes parkin ( PARK2 ) and PINK1 ( PARK6 ) .
This process is altered during aging and has relevance to human bladder pathologies.
This process is commonly referred to as systems consolidation theory.
This process is completed in young adults , and in the majority of individuals , KIR / NKG2A repertoires remain remarkably stable until old age.
This process is highly individualized and is influenced by multiple genetic , epigenetic and environmental factors.
This process is highly regulated by intrinsic and extrinsic factors , which may control the proliferation and / or maturation of neural progenitor cells.
This process is likely mediated by matrix metalloproteinases ( MMPs ) .
This process is mediated by languaging.
This process is of critical importance to prevent the invasion of microbes or other agents into tissues , avoiding the establishment of a chronic infection.
This process is poorly understood , despite the influence the phenomenon has on peripheral T-cell numbers.
This process is potentially useful to geriatricians who need to be experts in managing complexity.
This process is referred as translesion synthesis or TLS.
This process is referred to as steepening.
This process , known as perceptual narrowing , supports neural representation and thus efficient processing of the distinctive phonemes within the sound environment.
This process leads to the formation of reactive oxygen species , which may indirectly cause DNA damage.
This process must be tightly controlled , as its deregulation may result in fibrosis , scarring , and loss of tissue function.
This process of cellular self-digestion is involved in a number of physiological processes like survival , differentiation and development.
This process of gradual structural weakening of the face begins during the third decade and continues to worsen during the remainder of an individual's lifetime.
This process of network growth can improve access to social resources , boost self-esteem , reduce loneliness , and increase physical activity.
This process reached its peak within the first approximately @number@ million years of sex chromosome evolution and then leveled off.
This process requires carefully orchestrated interactions between cells and their extracellular matrix microenvironment.
This process starts before menses have changed , when fertility starts to be reduced.
This process suggests that a well-placed epidermal injury can stimulate an inflammatory cascade with dermal remodeling. < em > J Drugs Dermatol.
This process was essential for sustaining NK cell proliferation during development and the acquisition of cytolytic potential during inflammation or viral infection.
This process was near-completely inhibited by the P2X7 antagonists A438079 and AZ10606120 and the P2X1 / P2X7 antagonist MRS2159 but not the P2X1 antagonist NF499.
This process was repeated with PGC domains.
This profile could be explained by changes in the frontal lobe and its connections , starting at middle-age.
This profile was maintained after adjusting the model for sex , combined antiretroviral therapy regimen and year of combined antiretroviral therapy initiation.
This program coordinates cell survival and proliferation during tissue regeneration and repair in young animals.
This program includes versatile output features , where grouped data points can be easily exported into a spreadsheet.
This program is not conserved in laboratory mice , which have longer telomeres and constitutive telomerase.
This program may help to build commitment among medical students to choose careers in aging.
This programme , called \ "BrainCoach \ " , includes the technique of \ "motivational interviewing \ " to foster behaviour change.
This program model could be replicated to support the successful integration of other international health professionals into the workforce.
This program's clinical tracks and curriculum are described.
This progress , along with advances in biotechnology , has rendered possible the development of ever more sophisticated treatments employing novel mechanisms of action.
This progression appears to be dependent on context : the tissue ecosystem within individuals and lifestyle exposures across populations of individuals.
This pro-inflammatory condition probably is protective against infection , promoting the longevity of these subjects.
This project assessed dynamic balance and stability in aged lawn bowlers during the delivery stride.
This project demonstrates the feasibility of obtaining meaningful input on biorepository governance from diverse lay stakeholders.
This project examines community providers ' ability to proficiently administer a fall risk screening following a standardized training.
This project explores the relationship of nursing home profit status and innovativeness to the use of these advance directive programs ( ADPs ) .
This project provides a reference for care program planners and administrators.
This project set out to raise policymakers ' awareness of family caregivers through proposals to Republican and Democratic party platforms during the @number@ political season.
This project sought to deepen the connections of these elderly residents to society and to build elderly leadership and community capacity for future crises.
This project was initiated to identify key factors that improve communication between aging women and their primary care providers.
This pro-longevity effect might be mediated by improved protein homeostasis , as this protease is an integral module of the protein homeostasis network.
This promising instrument may advance the science of successful aging.
This promoted neutrophil infiltration , tumor cell ( TC ) adhesion to the endothelium , intravasation , lung colonization , and postsurgical metastasis.
This promotes cholesterol gallstone formation.
This promotes degenerative changes and occasional neurovascular ingrowth potentially contributing to the development of pain.
This promotion model deserves particular attention since it is applicable to any drug with a purportedly favourable risk-benefit ratio not supported by evidence.
This prompted our investigation to determine whether RalGAPs additionally modulate mTOR signaling.
This prompts us to examine the mechanisms underlying the potential regulation of H2S on the ion channels.
This property minimises axial deformations during pressure cycle.
This property of KR allows us to engineer oxidative damage specifically at the telomere in a light dose-dependent manner.
This proposed mechanism may be responsible for memory defects in AD but also for age-related memory decline.
This proposed virulence shift might contribute to the death of old or seriously ill people even in the absence of apparent disease.
This proposition rests on the observation of disproportionately greater age differences in memory for associations than in recognition of individual items.
This proprioceptive impairment was found not only in involved shoulders but also in uninvolved shoulders in patients with SIS.
This prospective 6-year follow-up study was designed to evaluate the changes in sleep stages and sleep continuity that occur in women during menopausal transition.
This prospective cohort study invited residents of @number@ private LTCFs in Taipei for study.
This prospective cohort study is the first to examine whether childhood sleep duration is associated with lifelong mortality risk.
This prospective , observational cohort study included @number@ community-dwelling older persons from across metropolitan Chicago participating in the Rush Memory and Aging Project.
This prospective single-center study was conducted to evaluate changes in the stiffness of the pancreas related to age and diffuse chronic pancreatitis.
This prospective study aimed to investigate the relationship between metabolic syndrome ( Met S ) and premature ejaculation ( PE ) among men.
This prospective study included @number@ healthy children ( newborn to @number@ y ) divided into four age groups.
This prospective study was conducted to investigate the clinical effects of microglia according to the aging process in newly diagnosed AD.
This protective effect is lost at menopause.
This protective effect on the mortality risk is not only statistically significant but also clinically relevant.
This protective mechanism seems to be reduced with aging both in experimental and clinical studies.
This protein addresses a lack of senescence markers and should be applicable to study the biologic role of senescence in other cancers.
This protein plays an important role in epithelial tight junction formation and immune function.
This protein plays a pivotal role in the resistance of tumors to chemotherapy , especially to paclitaxel.
This protein presented a significant age-related decrease , specially in individuals with CVDRF.
This protein-protein interaction modulates subcellular localization and endonuclease activity of APE1.
This protein regulates the unfolded protein-response pathway.
This protein was originally cloned as a putative pre-B cell colony-enhancing factor and also found to be a visceral fat-derived adipokine ( visfatin ) .
This proteomic analysis revealed that the disruption of the Msr system mainly affects proteins with redox , cytoskeletal or protein synthesis , and maintenance roles.
This protocol also provides examples of retinal changes in subjects with dementia , and discusses technical issues and current limitations of retinal imaging.
This protocol describes a technique for incorporating sensory adaptation into the simulations.
This protocol describes the current established methods for buccal cell collection , slide preparation , cellular and nuclear staining , and scoring criteria.
This protocol describes the methodological approach to be adopted for conducting this systematic review and meta-analysis.
This protocol measures externalization of aminophospholipids ( APLs ) to the outside of the plasma membrane using mass spectrometry ( MS ) .
This protocol presents a scoping review on the social participation of indigenous elders , intergenerational solidarity and their influence on individual and community wellness.
This protocol takes advantage of the characteristic of photopigments that display an orange color when kept in the dark.
This protocol was approved by the hospital institutional review board.
This provided minimum and maximum time estimates for the presence of each SSH on the island.
This provides a basis for controlled clinical studies that can test specific exposures that may enhance reserve.
This provides an impetus for the development of mitochondrial pharmacology , and some promising therapeutic targets for mitochondrial protective therapy have been identified.
This provides a specimen of bladder urine without biofilm contamination , and catheter replacement also improves clinical outcomes.
This provides clinicians a novel option for implementing early mobility training in a hospital-based environment.
This provides conditions for increased ceramide synthesis and follicular loss through ceramide-induced apoptosis is accelerated.
This provides evidence of intra-household insurance that mitigates the impact of an unexpected earnings shock.
This provides further knowledge essential in the assessment of renal disease and determination of renal function in the older subjects.
This provides health professionals with valuable information of neurodegeneration stages , and a potential to provide a better understanding of disease pathology.
This provides important data for loved ones of these patients when addressing goals of care.
This provides new evidence that spatial working memory plays a role in the control of perturbation-evoked balance-recovery reactions.
This provides novel proof for the involvement of AQP4 in the process of amyloid deposition in AD.
This provides preliminary in vivo evidence that tau is more closely linked to hypometabolism and symptomatology than amyloid.
This provides valuable evidence of the photorejuvenation effect of IPL in vivo.
This publication aims at finding ways to gain greater patient satisfaction in daily practice.
This publication discusses the safety profile of MFU-V based on data from a variety of sources.
This purine acts principally as an antagonist of the A2A receptors.
This purpose does not change even in elderly people with diabetes.
This putative protective effect of SCH was not found in subjects aged < 85 years.
This Q388stop mutation deleting the last @number@ amino acids was shown to impair activity-dependent dendritic outgrowth.
This qualitative descriptive study explored NP graduate perceptions on the adequacy of their education to prepare them to care for seniors.
This qualitative research has the aim to know the meaning of the aging process in the work market referring to the aged people.
This qualitative research , may have indirectly selected the most favorable agents concerned by the issue : those who agreed to answer.
This qualitative study analyzed the conjugal grief experience of veterans ' widows.
This qualitative study examined the experience of being depressed among African-American elders and their perceptions of barriers confronted when contemplating seeking mental health services.
This qualitative study explores old age psychiatrists ' experience of and approach to working with patients at the EOL.
This qualitative study investigates the depiction accuracy of dementia's clinical features in motion pictures.
This qualitative study of @number@ older adults examines how they allocate their resources in the face of chronic health conditions.
This qualitative study provides evidence on the acceptability of an effective postsurgical exercise intervention targeting the self-management of cancer-related fatigue to fill this gap.
This qualitative study provides systemic insights into how and why falls occur in community-dwelling octogenarians.
This qualitative study was completed in collaboration with a large home and community care organisation in Ontario , Canada , in 2010-2011.
This qualitative study was designed to examine the benefits of leisure to older Korean women.
This qualitative study was part of a cross-national project entitled ENABLE-AGE which examined the relationship between home and healthy ageing.
This quality assurance review of @number@ consecutive geriatric psychiatric inpatients demonstrated discrepancies between chart documentation and actual ophthalmologic pathology present in the patients.
This quality improvement study sought to improve immunization rates across @number@ LTC facilities and identify persistent barriers to better performance.
This quantitative approach not only clarifies the picture but also has implications in biology and medicine.
This quantitative research study uses survey data of women born between @number@ and @number@ in Australia.
This quasi-experimental study included the analysis of pre- and posttest surveys completed by the service-provider attendees ( N = @number@ ) .
This quasi-program causes over-activation of female reproductive system , which is very vulnerable to over-activation.
This question is still highly controversial , with prior studies providing contradictory findings.
This questionnaire was answered by @number@ individuals ( aged @number@ years , 21-85 years ) , predominantly suffering from severe haemophilia.
This RAD51 / MCM8-9 axis is distinct from the recently described RAD52-dependent DNA synthesis pathway that operates in early mitosis at common fragile sites.
This raises an intriguing possibility that Nox4 may play an important role in mediating aging of the heart.
This raises a question regarding the relative roles of the various forms of sunlight-induced DNA damage on skin carcinogenesis and photoaging.
This raises important questions , as clinical guidelines clearly recommend to limit the use of artificial nutrition in contexts of limited life expectancy.
This raises the hypothesis that low vitamin D is related to poor mental health.
This raises the need for more empirical research to help consolidate this theoretical model.
This raises the possibility that APOA5-1131T > C may affect the risk of early MI over and above effects mediated by triglycerides.
This raises the possibility that gut hormones are influenced by endocannabinoids.
This raises the possibility that IIV may also predict future cognitive decline and , indeed , neuropathology.
This raises the possibility that reduced IKAP levels may affect mitochondrial proteins and their function in the nervous system , particularly in the retina.
This raises the possibility that reducing levels of p75 could be a treatment for AD by preventing the effects of Aβ.
This raises the question how the sequestration of telomerase might have evolved.
This raises the question of how early memories can be so influential if they cannot be recalled.
This raises the question of the extent to which these groups use visual cues when disambiguating information.
This raises the question of whether p53 , a cellular stress sensor , regulates muscle tissue repair under stress conditions.
This raises the question whether cancer vaccination is feasible at older age.
This raises the question whether contemporary populations of older adults are experiencing better or worse objective as well as subjective health than earlier-born cohorts.
This raises the question whether MDS is , in part , related to an inability to adequately cope with DNA damage.
This randomized-controlled trial investigated the effect of physical exercise programme ( PEP ) on happiness among older adults in Nowshahr , Iran.
This randomized , placebo-controlled trial was designed to determine the safety and clinical efficacy of senicapoc in SCD patients.
This range and flexibility of benefits indicate the importance of more systematically characterizing the ways in which older adults are involved with NORC programs.
This rate is much lower than in other countries and is even comparable to the frequency of LOAD patients in our country.
This rather small numeric change might represent a relevant impact on an individual's ability to understand speech in everyday life.
This ratio increased with increasing age of observers.
This ratio may provide a useful metric for differentiating freshly emitted ( SHS ) from aged smoke ( THS ) .
This RCT provides evidence that a multimodal exercise intervention can achieve larger effect sizes than those generally resulting from single modality interventions.
This reaction affects the Cu speciation , which explains why blood Cu isotope composition is impacted by the cessation of menstruations.
This reaction is shown by visible spectroscopy to occur @number@ times faster in the R-state than in the T-state.
This reactivity depends on the balance between various mediators , including nitric oxide , endothelin , and prostanoids , among others.
This \ "readjustment \ " has been shown to have a great impact on retention of cellular homeostasis since it promotes lifespan extension.
This reasoning is highly consistent with the care orientation.
This redistribution of adipose tissue in favor of visceral fat influences negatively both longevity and healthy aging as shown in numerous animal models.
This redox reaction inhibits the MEF2C-PGC1α transcriptional network , contributing to mitochondrial dysfunction and apoptotic cell death.
This reduced asymmetry in older adults may at least in part underlie the speech perception difficulties / presbycusis experienced by aging adults.
This reduced mean shear in the old was driven by attenuated antegrade shear as there were no differences in retrograde shear.
This reduced mitochondrial quality with age is also likely to sensitize skeletal muscle mitochondria to elevated angiotensin or beta-adrenergic signaling associated with heart failure.
This reduces an older person's capacity for safe , independent community living.
This reduction did not occur among those in the wait list condition.
This reduction has long been viewed as a result of passive slowing of metabolism.
This reduction induces metabolic dysfunction both in the body and the brain , leading to AD pathogenesis.
This reduction in IFN-I and IFN-III were a result of age-associated impaired phosphorylation of transcription factor , IRF-7.
This reduction is associated with a delay in the recruitment of essential DDR factors.
This reduction is not reflected in behaviour , apart from a general slowing of older participants.
This reduction is thought to be due in part to age-related differences in encoding-related processes.
This reduction of myogenin protein is observed in G1-arrested cells and leads to decreased expression of late but not early differentiation markers.
This reduction of spatial information allowed us to investigate the anatomical features of each patient , demonstrated in an Alzheimer's disease group.
This reduction thus increases the risk of osteoporosis and osteoporosis-related iatrogenic , traumatic or pathological fractures.
This reduction was even stronger when the healthy lifestyle behaviours were combined.
This reduction was evident in all sex-age groups except the youngest men.
This reduction was found to be due to reduced proliferation and not because of enhanced apoptosis in the hippocampus.
This reflected feminine traits.
This reflects a tension between passive and empowered client roles in the context of aged care provision.
This reflects poor health knowledge and inadequate health-care utilisation among Malaysian men.
This reflects the mosaic of skin ageing.
This regenerative cycle of mitochondrial ROS formation and release was named ROS-induced ROS release ( RIRR ) .
This regimen , however , deserves to be optimized in terms of duration and dose of DOX.
This region harbors the ISL1 ( ISL LIM homeobox @number@ ) gene.
This region is intensively studied for mutations causing severe developmental / genetic disorders.
This region partially overlapped the region of hypometabolism associated with delusions.
This regression causes tumor hypoxia , which could trigger certain cancer cells to become more invasive and metastatic.
This regression model explained @percent@ of the variance in successful aging.
This regulation , however , becomes impaired in older adults in light of age-related changes in endocrine function.
This reinforces the need for regular ophthalmic care in elderly patients to improve their quality of life by optimizing vision.
This relates in part to the poorly developed evidence base and lack of high-quality research in this area.
This relation is absent in very old people with cognitive impairment.
This relation remained highly significant even after the influence of potential confounders was accounted for by the partial correlation analyses.
This relationship becomes more pronounced with increasing age : with higher IQ , a faster thinning of the cortex is found over time.
This relationship between marital status and telomere length is independent of presumed benefits of marriage such as social support and a healthier lifestyle.
This relationship between white matter microstructure and perceptual speed remained significant after excluding persons in a preclinical dementia phase.
This relationship combined with the age effect , with the CQP for all three loudness levels being greater for the older speakers.
This relationship continues to be strong as these individuals grow older into their eight decade.
This relationship could be partially explained by a reduced right hippocampus volume in a subsample of @number@ tested dementia patients.
This relationship disappeared , however , when only data from post-menopausal women were included in the analysis.
This relationship disappears in subjects > 65 years of age , suggesting a differential impact of visceral fat deposition according to age.
This relationship is gender-specific.
This relationship is particularly evident in older individuals , suggesting a role of physical activity in combating the typical age-induced decrements in telomere length.
This relationship may be explained by the fact that higher order cognitive functions such as executive functions are called upon while walking.
This relationship persisted in multivariable analysis.
This relationship remained statistically significant after controlling for other menopause confounders in multivariate modelling.
This relationship was apparent from age @number@ years and continued into later life.
This relationship was independent of American Society of Anesthesiology ( ASA ) score.
This relationship was no longer significant after simultaneous adjustments for metabolic and health variables.
This relationship was no longer statistically significant at @number@ year ( regression coefficient = @number@ @percent@ CI : @number@ @number@ ) .
This relationship was not evident for diastolic BP recovery.
This relationship was not observed in older adults in the placebo condition.
This relationship was specific to probes presented in the left visual field and measured at ipsilateral electrode sites.
This relationship was strengthened when combined with low BMI.
This relation was statistically significant for most cognitive domains in adjusted models.
This relation with age accounted for @percent@ of the variation of On.AspR ( @number@ ) .
This remains an underserved area in most countries.
This remapping requires inhibition to suppress the automatic activation of the ipsilateral responses.
This remarkable correlation between AMH mRNA levels in cumulus cells in respect to age suggests that AMH may be involved in follicular aging process.
This remarkable demographic change has been accompanied by a shift in disease prevalence so that age is now the major determinant of most common diseases.
This remarkable dissociation between neural activity and behavior in the older adults indicated that the P1 and CDA did not accurately assess their VWM capacity.
This remodeling , in turn , promotes enhanced cell surface expression of MARCO and bacterial phagocytosis.
This reorganization of host priorities represents a beneficial response that is normally adaptive but may become maladaptive when the profile of microglia is compromised.
This replication fork disruption can lead to the dissociation of the replisome and the formation of DNA damage.
This report attempts to answer the aforementioned questions.
This report characterizes the affinities of over @number@ new AChE inhibitors which could act as resurrecting agents for the aged AChE-OP adduct.
This report compares the effect of lipid and polymeric nanoparticles upon human neutrophils in the presence of cationic surfactants.
This report considers the advantages and disadvantages of current methods for counting glomeruli and describes the new magnetic resonance approach.
This report critically reviews the potential for GH augmentation during aging with emphasis on men since women appear more resistant to treatment.
This report demonstrates the power of exome sequencing to determine the cause of rare hereditary diseases with incomplete or atypical phenotypes.
This report describes @number@ face-lifts without any facial nerve problems.
This reported proteome offers a reference data set for future basic or translational studies on VaD.
This report evaluates gross and histological lesions in relatively new , classic , and rarely explored mouse inbred strains.
This report examines the available evidence regarding the role , significance , and mechanisms of DHF.
This report extends the range of TREM2 mutations that cause NHD phenotype.
This report from a prospective longitudinal study compares cognitive functioning in @number@ breast cancer patients @number@ year after chemotherapy to that of @number@ healthy individuals.
This report further supports a primary involvement of altered brain cholesterol metabolism in the complex pathogenesis of Alzheimer's disease.
This report identified a novel transcriptional regulatory element , the α2M transcription enhancement element ( ATEE ) , within the α2M promoter.
This report is based on the sample studied in @number@ ( N = @number@ ) .
This report is intended for use in public health research , policy development and practice.
This report is the first to describe the inhibitory effects on oxidative stress of secondary metabolites from S. pubescens.
This report is the first to evaluate pelvic movement by both a triaxial accelerometer and a triaxial gyroscope simultaneously.
This report presents national estimates of RCFs using data from the first-ever national probability sample survey of RCFs with four or more beds.
This report presents national estimates of residential care communities , using data from the first wave of NSLTCP.
This report presents national estimates of residents living in residential care , using data from the first wave of NSLTCP.
This report presents the electrophysiologic bases , technique , animal experiments , and initial clinical experience of myoablation.
This report proves that the fluorescent probe DEVD-TPE is highly sensitive to caspase-3 and has potential prospects in the rapid screening of NSCLC.
This report provides added support for PADM use in complex ventral hernias.
This report provides an update on our current knowledge of human nephron number and the associations with adult health and disease.
This report provides estimates of the incidence of select risk factors for cardiovascular disease among members of the active component of the Armed Forces.
This report provides recent knowledge regarding the therapeutic potential of MTs in neurodegenerative disorders of aging such as Parkinson's disease and Alzheimer's disease.
This report recommends research priorities that can help close the gaps in our understanding of aging as it relates to HSCT and cancer.
This report reviews the data presented , as well as key discussion points from the meeting.
This report will focus on the employees ' physical capacity during a nine-month program.
This repositioning seems to affect gene expression in these cells and may play a role in progression of the disease.
This represented around @percent@ of the variance in foodservice satisfaction.
This represents a significant economic burden on the health care system.
This represents a significant improvement over similar routines using PSi where times of > 10 h are common.
This represents the eighth leading cause of cancer incidence and the sixth leading cause of cancer death overall.
This repressive effect of SETD8 in senescence was mediated by directly maintaining the silencing mark H4K20me1 at the locus of the senescence switch gene p21.
This requires adaptation of the working conditions to compensate for age related visual changes.
This requires an alternation of generations.
This requires an understanding of the physiology in the paediatric population compared to that of adults.
This requires any pathological features of the patient cells used for reprogramming to be eliminated during iPSC generation.
This requires changes in the nursing and medical approach , as well as education in the subtleties of the two intersecting medical realities.
This requires further exploration but suggests the need for careful planning of retail in residential environments , particularly near housing for older adults.
This requires further research investment into the detailed study of interactions between brain structure , function and connectivity.
This requires the urgent for the development of effective therapies , and of tools for early diagnosis of the disease.
This research aimed to validate and assess the reliability of the Canadian Nutrition Screening Tool ( CNST ) in the ' real-world ' hospital setting.
This research complements prior research by signaling the value of considering both responses to discrimination as complementary rather than mutually exclusive.
This research contributes a more nuanced understanding of living arrangements among the elderly than its predecessors , which neglected the role of marital status.
This research evaluated the effectiveness of reading instruction targeting oral reading and phonological awareness for children with Down syndrome ( affecting chromosome @number@ ) .
This research examined age differences in the accommodation of reading strategies as a consequence of explicit instruction in conceptual integration.
This research examined beliefs about the experience and expression of emotions across the life span , especially across the adult years.
This research examined longitudinal associations between caregiving stressors , caregiver depression , and quality of care.
This research examined the association between multiple dimensions of wellness and cognition among aging adults.
This research examined the degree to which this generalized across arousal levels associated with social images.
This research examined the relationship between health and life satisfaction in women over @number@ years of age in local communities.
This research examines male endurance athletes ' experience of aging and / or reaching the perceived limits of physical performance.
This research expands upon the life expectancy literature by examining the influence of familial health histories.
This research explored how and why hearing loss continues to be stigmatized through a study of media messages about hearing loss.
This research explored the balance benefits to untrained older adults of participating in community-based resistance and flexibility programs.
This research explores genotype differences ( e2 , e3 , e4 ) in the allocation of visuospatial attention in mid-adulthood.
This research extends the effect of diet on asthma in adults.
This research focuses on the effects of hormone therapy ( HT ) on FCAs and interhemispheric interactions in postmenopausal women.
This research has generated large amounts of experimental data that is increasingly difficult to integrate and analyze with existing databases and domain knowledge.
This research has implications for future research as well as community interventions and programs.
This research highlights the importance of the hospital setting in understanding nurses ' ability to provide quality geriatric care.
This research , however , was restricted to inadequate study designs in the elderly.
This research informs the development of a relational framework based on stakeholder perspectives.
This research investigated how rurality affects the implementation of patient classification in Ontario long-term care homes.
This research investigates the effect of micronutrient powder addition on the sensory properties of selected foods commonly served in long-term care.
This research is important because it strives to understand the factors that predispose some cancer survivors to more negative quality-of-life outcomes.
This research is part of the InCHIANTI Study , a prospective population-based study of older persons in Tuscany , Italy.
This research provides greater understanding of the existing limitations associated with nightstands.
This research purpose was investigating BINS psychometric properties.
This research represents an important first step in improving self-awareness among older drivers through self-screening.
This research reveals that only @percent@ of male dancers will seek medical help because of occurrence of musculoskeletal pain.
This research should improve understanding of memory complaints , preclinical and clinical dementia , and help target processes for rehabilitation.
This research studied serum IgG to periodontal microbiota as possible predictors of incident AD.
This research studied whether learning and updating of haptic target configurations differs as a function of age.
This research study aimed to evaluate the effectiveness of a support group led by a social worker for Chinese persons with mild dementia.
This research supports the importance of cultivating mindfulness in late life to ensure cognitive and emotional well-being.
This research was undertaken to guide national brain health awareness and education strategies.
This reserve is thought to play a regulatory role in energy homeostasis during ageing.
This residual immune activation seems to be associated with accelerated aging and an increased incidence of non-AIDS-defining illnesses.
This residual variance represents the discrepancy between an individual's predicted and actual memory performance.
This resource enables a thorough epidemiological description of the neuropathology associated with dementia in the UK.
This response in turn affects endothelial cell contractility , which is an important property that regulates endothelial stiffness , permeability , and leukocyte-vessel wall interactions.
This response involves signaling cascades that activate appropriate damage repair pathways , arrest the cell cycle , and ultimately determine cell survival or death.
This response is time-limited and as bone loss progresses , circulating sclerostin is lowest in subjects with severe osteoporosis.
This restraint might be because of the poor proliferative capacity of aged donor hepatocytes or the regenerative impairment of the recipient livers.
This result allowed us to test various hypotheses about the required conditions for the emergence of menopause and extensive post-reproductive life-span.
This result can be seen in the context of social cognition deficits and poor inhibitory control in patients with FLE.
This result correlated with the increase in GLO-1 activity in the whole blood samples of type @number@ diabetes patients.
This result could be due to individuals in neighbourhoods with low healthy food availability travelling outside their neighbourhood to obtain healthy food.
This result did not change when data from participants who were diagnosed with dementia within @number@ years after MRI assessment were excluded from the analysis.
This resulted in a T / S ratio and was converted to base pairs ( bp ) .
This resulted in a variable treatment duration of 2-52 weeks.
This resulted in DNA damage disrepair , apparent by the increased frequencies of both spontaneous and chemically induced structural chromosomal aberrations and sister chromatid exchanges.
This resulted in failing to include a similar number of patients in the control condition versus the intervention condition.
This resulted in increased insulin-induced suppression of hepatic gluconeogenesis , improved glucose tolerance , and reduced hepatosteatosis with aging.
This resulted in @number@ articles.
This resulted in reliable information about electrical somatosensory perception in both groups at equivalent received amounts of current.
This result implies that there is a local thrombus-prone site in LAA when AF occurs.
This result indicates that IGF-1 blocks the downstream apoptotic consequences of Epoxomicin treatment leading to decreased proteasome function.
This result indicates that in self-paced tapping , the bimanual advantage is absent in elderly.
This result is illustrated by a comparison of TCALs for the US with those for Denmark , Japan , and other high-longevity countries.
This result is important for the discussion about universal fitness measures and which parameters are maximized by natural selection.
This result is in line with the polyclonal profile of B Lymphocyte populations that reside in reactive lymph node tissues.
This result is statistically heterogeneous.
This result may offer the possibility of early detection of Alzheimer's disease via improved discrimination of aMCI subtypes.
This result showed that postural control is prioritized ( \ "postural first \ " principle ) when seriously challenged.
This results in an age gap between SDoH research and government budget priorities.
This results in an increased disease burden in the aged population , even with good immunisation programmes in place.
This results in an increase in the anorexia due to cachexia in older persons.
This results in complex medication regimens with the potential for significant drug-drug interactions and increased morbidity and mortality.
This results in ideal scar locations , situated at the sub-antitragal groove and at the cheek junction.
This results in intradermal tattooing of the topical product.
This results in more septic patients being admitted to intensive care units.
This results in the appearance of premature aging.
This results in the generation of free radicals which play an important role in pathophysiology of aging and diabetic complications.
This results in the largest predicted shortages which may fuel global competition for skilled health workers.
This result stands in contrast to previously reported findings the vast majority of prior research conducted with dating and newlywed couples.
This result suggests an impairment of multiple levels of object integration processing even at an early stage of the disease.
This result suggests that CHCHD2 mutations might not be the common cause of PD in South Italy.
This result suggests that increased connectivity reflects a decline in brain function rather than a compensatory process.
This result suggests that PP as a presumed marker of vascular aging may predict the presence of sub-clinical cerebrovascular diseases.
This result suggests that the age-related decline in 3-D shape discrimination from motion is related to decline in GABA concentration in visual cortex.
This result suggests the importance of reducing fat mass in order to achieve peak bone mass in young adult women.
This result supported the likely presence of unknown diverse mechanisms on top of the common cascade of atherosclerosis.
This result supports the Embodied Capital Model rather than the Grand-Mother Hypothesis.
This result was particularly relevant in subjects over @number@ years old ( p < 0.05 ) .
This result was replicated in Experiment @number@ but distancing instructions minimized the age difference in recall for high-arousal , negative images.
This result was statistically homogeneous ( percentage of the total variation across studies due to heterogeneity [ I2 ] = @number@ ) .
This retrospective analysis of a single-center database of urinary stones helps characterize the M-C epidemiology of urolithiasis in Belgium.
This retrospective cohort study included individuals ≥65 years old with CKD ( n = @number@ ) in Taipei City.
This retrospective cohort study sought to evaluate the age trends and related developments in the methadone population of Basel-City , Switzerland.
This retrospective , longitudinal , observational study concluded in @date@ .
This retrospective longitudinal study evaluated patient characteristics associated with CRC screening in our HIV cohort.
This retrospective , parallel-cohort , hypothesis-generating study investigated whether treatment with rivastigmine is associated with reduced prescription of antipsychotic medications compared with treatment with donepezil.
This reuptake mechanism is present not only in neurons but also in other cells such as platelets.
This revealed how CC-related neural function participates in cognitive maintenance in the presence of amyloid deposition , potentially explaining excellent cognitive function among Supernormals.
This revealed that the expression of key senescence-associated genes are down-regulated upon the induction of pluripotency in primary AFCs ( AFiPSCs ) .
This revealed the heterogeneity of health conditions , and the constrained mobilities of seasonal retirees.
This reveals a dramatic failure of metacognitive control , in the absence of any obvious monitoring deficit , in older adults.
This revelation has led researchers to consider candidate mechanisms precipitating the cascade of neuropathological events that eventually lead to clinical Alzheimer's disease.
This review addresses available data of promising practices for improving CHD medication adherence.
This review addresses cell type- and cell state-specific function ( s ) of Rheb and mainly focuses on neurons and their surrounding glial cells.
This review addresses the cellular and molecular mechanisms of cadherin-based tissue morphogenesis.
This review addresses the pathogenesis and mechanisms of these mutant alleles and the unique interactions of both of age and gender.
This review addresses these issues.
This review addresses the state of the art regarding the crosstalk between light and the circadian system.
This review aimed to compare these two methods for this hot issue.
This review aimed to determine the incidence , prognostic factors and impact of postoperative delirium in vascular surgical patients.
This review aimed to determine the prevalence of food addiction diagnosis and symptom scores , as assessed by the YFAS.
This review aimed to evaluate the evidence for TMF in dementia.
This review aimed to identify the needs of stroke survivors as perceived by their caregivers.
This review aimed to review such data and to guide future research.
This review aims to assist researchers in better interpreting the diversity of findings concerning sedentary behaviour and weight status.
This review aims to decipher the physiological roles of carnosine , based on its biochemical properties.
This review aims to describe outcomes for patients with osteoporotic fragility fractures as part of FLSs.
This review aims to determine the relationship between HPA throughout life and LLMS above age @number@
This review aims to discuss the evidence supporting the link between chronic stress , cognitive function and mental health.
This review aims to evaluate the feasibility and the expected benefits of prehabilitation on the postoperative recovery course and the reduction of the postoperative morbidity.
This review aims to focus on IR-mediated physiological events in a mechanistic way.
This review aims to give a translational overview on the biological basis of atrial remodeling and the proarrhythmic mechanisms involved in the fibrillation process.
This review aims to identify interventions and strategies that can significantly reduce inappropriate prescribing in the elderly.
This review aims to identify studies that evaluated community samples of patients without a history of neurological disease and attempts to combine these data.
This review aims to identify the mechanisms of ED in the penile aging process in experimental and clinical data.
This review aims to integrate the current knowledge of mechanisms underlying elevated sympathetic outflow with age.
This review aimsto introduce the reader to the concept of alcohol-mediated liver damage and the mechanisms driving injury.
This review aims to provide a clearer picture of the needs of this growing patient population.
This review aims to provide a concise overview of pharmacological treatments for depression in dementia.
This review aims to provide an overview of the ageing endocrine system and its potential impact on health and disease in the elderly.
This review aims to shed light on the scientific background suggesting feasibility of using plant cells as a basis of anti-age cosmetics.
This review aims to summarize the cellular and molecular mechanisms that could mediate the augmented chemoreceptor activity induced by intermittent hypoxia.
This review aims to summarize the current body of knowledge and to give a recommendation concerning a surgical treatment cascade.
This review aims to summarize the current state of the art concerning imaging of the aortic valve by CT and the potential clinical applications.
This review also discusses experimental techniques useful in characterizing protein-protein transnitrosylations.
This review also highlights a need for greater provider training in pain management to meet the needs of a changing U.S. population.
This review also provides an overview of lycopene metabolism , and the molecular pathways involved in the potential beneficial properties of lycopene and apolycopenoids.
This review analyzes bottle-fermented sparkling wine research at each stage of production by evaluating existing knowledge to identify areas that require future investigation.
This review analyzes the impact of metabolic syndrome on white matter microstructural integrity , brain structure abnormalities and their relationship to cognitive function.
This review and meta-regression analysis studies the effect of aging on MMSE scores in schizophrenic patients.
This review appraises recent developments in the use of OCT for assessing glaucoma progression.
This review argues that to fulfill this niche , cell-penetrating peptides may provide promising therapeutics.
This review article aims to provide a practical guide to anaesthetic management of the elderly surgical patient.
This review article aims to provide a practical guide to anesthetic management of elderly outpatients.
This review article describes the effects of aging on the responses of geriatric patients to anesthetic and analgesic drugs used during ambulatory surgery.
This review article discusses the possible role of HIF-1α as a neuroprotector in AD and the future perspectives.
This review article discusses the pros and cons of cell therapy for melanoma brain metastases.
This review article explores the main roles played by TLR2 in the pathogenesis of chronoinflammaging in patients suffering from AD.
This review article focuses on highlighting recent advances in current knowledge on anti-aging natural products grouped and presented according to their family origin.
This review article focuses on proteasome activation studies in several species and cellular models and their effects on aging and longevity.
This review article is devoted to the issues of international cooperation on ageing.
This review article summarizes the contribution of mitochondrial pathology to both common and rare skin diseases.
This review article summarizes the emerging data from this rapidly growing field of intracellular trafficking signaling in the pathogenesis of neurodegeneration.
This review article will focus on the effects of genistein on skin health.
This review assessed the role of comprehensive geriatric assessment ( CGA ) for such people.
This review attempts to collate the salient findings from these studies.
This review begins by addressing the question of whether eccentric actions result in physical damage to muscle fibers and / or connective tissue.
This review briefly summarizes studies that examine aging skeletal muscle during unloading and reloading.
This review characterizes inhibition as a set of processes rather than a unitary process.
This review collates recent studies to determine the size of the nuclear domains and its change with activity.
This review collects current knowledge about the composition and function of insoluble , nuclear protein inclusions from the protein homeostasis perspective.
This review collects the diverse experimental evidence that leads to these conclusions.
This review compares and contrasts the effects of estradiol on the developing and aging brain and highlights new avenues of exploration and therapeutic development.
This review comprehends patents pertinent to the preparations and uses of sesame seed lignans in health promotion.
This review concludes with possible therapeutic approaches that best fit the unique needs of older adults , especially with regard to multimorbidity and polypharmacy.
This review considers a complex genetic basis.
This review considers current knowledge of these potential mechanisms that threaten to create an intergenerational cycle of obesity.
This review considers how different components of the neuromuscular system may be influenced by estrogens and so affects neuromuscular function in postmenopausal women.
This review considers @number@ important astrocytic functions , that when disrupted , can affect neuronal metabolism.
This review consists of a summary of the INSPIRE workshop and the WG deliberations.
This review covers a wide topic of neurosteroids and brain aging , and provides insight on the mechanisms behind stress-induced AD or dementia.
This review covers present-day ideas of the female organism reproductive system neuroendocrine regulation in aging.
This review covers some of the chemicals believed to decelerate the appearance of age-related diseases in different rodent models.
This Review covers the current status and controversies surrounding the potential of sirtuins as novel pharmacological targets , with a focus on SIRT1.
This review covers the epidemiology of prostate cancer in elderly men.
This review covers the recent advances in Klotho research and discusses novel Klotho-dependent mechanisms that are clinically relevant in aging and age-related diseases.
This review covers the spatial and temporal rules governing induction of hippocampal long-term potentiation ( LTP ) by theta-burst stimulation.
This review critically analyzes that paper and considers some aspects of the crosstalk between the nuclear and mitochondrial genomes.
This review critically assesses this notion.
This review critically summarizes the current literature to investigate whether physical fitness and function benefits are engendered through the practice of yoga in older adults.
This review critiques the implications of HIT for cerebrovascular function , with a focus on the mechanisms and translational impact for patient health and well-being.
This review deals with some of the structural , functional and metabolic features of aging nervous system and discusses briefly the functional consequences.
This review deals with the aging immune system and its interplay with sex steroid hormones.
This review deals with UVB-induced alterations to the blood and lymphatic systems in skin and the molecular mechanisms involved.
This review defines water-loss and salt-loss dehydration.
This review demonstrates that studies that have examined this potential link are very rare.
This review describes and summarizes our present molecular biological information and knowledge about the Helicobacter infective component , cell functions and processes.
This review describes available evidence about the consequences of transfers from RACF to hospital.
This review describes evidence that mitochondrial reactive oxygen species ( mROS ) are of great importance under many physiological and pathological conditions.
This review describes how to assess cardiac aging using echocardiography , and how to interpret the clinical relevance of the findings.
This review describes in detail the preclinical and clinical development of cabazitaxel.
This review describes LOH and the current guidelines for its treatment and management.
This review describes the different types of memory including hippocampal-based memory that is vulnerable to aging.
This review describes the effects of APOE ɛ2 on the structure and function of the brain.
This review describes the most current information regarding the molecular and physiological relevance of SIRT6 in the context of epigenetics , metabolism and disease.
This review describes the range of options and the implications of each option for long-term care in the United States.
This review describes the recent molecular advances that have been uncovered in normal and diseased mammalian cells.
This review describes the role of various imaging modalities in the diagnosis and treatment of vascular cognitive impairment.
This review describes the state of our knowledge of androgen-related contributions to neurological injury and recovery following cerebral ischemia that occurs following stroke.
This review describes various mechanism and factors involved in aging of articular cartilage and chondrocytes.
This review details evidence for the ability of nutritional agents to manage these aging risk factors.
This review details our current knowledge of the dissolution process and the players involved in catalyzing this mechanistically complex means of completing homologous recombination reactions.
This review details some of these processes and the activities essential to achieve the immortality of the mammalian germ line.
This review details the current knowledge related to developmental changes determining intestinal drug absorption and pre-systemic metabolism.
This review details the mechanisms of neurodegeneration and highlights the beneficial effects of cannabinoid treatment.
This review discusses each of these important factors to provide a framework for understanding the complex and current challenges of managing the septic patient.
This review discusses evidence for the role of oxidative stress and inflammation in regulating the length of telomeres in mammalian cells during senescence.
This review discusses experimental studies of potentially immortal Hydra which have made contributions to answering this question.
This review discusses how changes in the elderly lead to impaired healing or chronic wounds.
This review discusses key astrocytic responses to ischemia including , reactive gliosis , excitotoxicity , and neuroinflammation.
This review discusses major findings from the Women's Health Initiative Memory Study ( WHIMS ) .
This review discusses polymicrobial interactions with the host in both health and disease.
This review discusses recent advances in macrophage and neutrophil biology in healthy aging and cancer.
This review discusses some of the common etiologies and diagnostic and management options.
This review discusses some of these emerging mechanisms and approaches in the translational medicine of AD.
This review discusses the amount of vitamin D supplementation needed and a desirable 25-hydroxyvitamin D level to be achieved for optimal musculoskeletal health.
This review discusses the application of new and existing skin rejuvenation techniques to clinical practice.
This review discusses the biology of sirtuins and their potential as mediators of caloric restriction and pharmacological targets.
This review discusses the complexity of factors linking hypertension to brain functional and structural changes , and to cognitive decline and dementia.
This review discusses the current knowledge surrounding PGD2 , and future steps needed to translate these findings into novel therapies for patients with AGA.
This review discusses the epidemiology , clinical course , prognosis and treatment of EOS.
This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli.
This review discusses the impact of an impoverished environment on cognition in animal experimental studies and human experimental studies with community-dwelling and institutionalized older people.
This review discusses the importance of early therapeutic intervention during the prodromal stage that precedes irreversible degeneration in AD.
This review discusses the most important factors that influence our telomeres.
This review discusses the opportunities and challenges involved with research of the evolving public health problem of infections among nursing home residents.
This review discusses the opportunities in the various types of cell-based therapy , their limitations , and what is possible for India.
This review discusses the pathophysiological mechanisms related to oxidative stress and contributing to suboptimal aspirin action or responsiveness.
This Review discusses the pathways that are involved in this crosstalk and thus regulate this complex relationship between adult neurogenesis and stress.
This Review discusses the potential usefulness of the worm Caenorhabditis elegans as a model organism for chemists interested in studying living systems.
This review discusses the processes of DNA-damage-response and DNA-damage repair in stem and progenitor cells of several tissues.
This review discusses the promise and prospects of resveratrol in the management of skin disorders and the associated challenges.
This review discusses the recent discoveries regarding the SIRT6 enzyme.
This review discusses the regulation of cellular and whole body energy metabolism by mTOR , with particular focus on the non-cell autonomous function of mTOR.
This review discusses the role of genetics , sunlight , diet , cardiovascular factors , smoking , and alcohol as possible risk factors for AMD.
This review discusses the role of maternal and in utero influences on the developmental priming of T2D risk.
This review discusses the role of mtDNA methylation and potential epigenetic-like modifications of TFAM with respect to mtDNA transcription and replication.
This review discusses the role of oxidative events of tissue degeneration and aging in general , and for the skin in particular.
This review discusses the role of the inflammatory environment in the development of chronic diseases in the aging population and also proposes a common pathology.
This review discusses these various strategies to assess their current status and future potential for this emerging research field.
This review discusses the significance of these proteins with the emphasis on the role of α-synuclein in mediating post-ischemic brain damage.
This review discusses the unique contribution of nonhuman primate research to our understanding of the neurocognitive effects of estrogens throughout the adult lifespan in females.
This review documents in detail the current understanding of the mechanisms through which resistance to anti-PD1 / PD-L1 therapy occurs.
This review does not discuss nonpharmacologic treatments of pain.
This Review emphasizes the contributions of sex steroid hormones to the relationship between sex and AD.
This review ends by suggesting a short assessment of CGA to be used in ED and ways to improve home discharge management from ED.
This review evaluates available methodology , with emphasis on the limitations of existing techniques most often related to the underlying assumption.
This review examines cholesterol asymmetry in SPM , potential mechanisms of regulation and impact on membrane structure and function.
This review examines evidence relating androgens to cardiovascular risk in older men.
This review examines in particular the effects of sodium and potassium on vascular function.
This review examines patient populations for whom hypocaloric nutrition can be both appropriate and beneficial.
This review examines recent developments in the understanding of why the elderly hip becomes fragile.
This review examines sex and gender differences in the development of dementia with the goal of highlighting factors that require further investigation.
This review examines some of the reasons why older people are at greater risk of drug-related adverse events such as falls.
This review examines specific innate and adaptive immune responses affected by aging that might affect the inflammatory response in older adults with asthma.
This review examines the association of arterial stiffness with cardiovascular disease.
This review examines the available data on the effects of nutrition on cognitive impairment.
This review examines the concept of compartment-specific MVB functions in endosomal protein trafficking and signaling within synapses , axons , dendrites and cell bodies.
This review examines the current evidence for protein aggregation in neurodegenerative disease states and discusses future mechanisms of therapeutically targeting the endoplasmic reticulum.
This review examines the current knowledge regarding the regulators of AHN and the influence of prenatal and postnatal stress on later AHN.
This review examines the current literature on quantitatively measured gait impairment in older adults with mild cognitive impairment or a dementia subtype.
This review examines the current practice of preoperative evaluation in geriatric anesthesia and provides an overview of new insights in this field.
This review examines the hypothesis that cellular senescence might contribute to lifestyle-related disease.
This review examines the long-awaited functional impact of Aβ on synaptic plasticity.
This review examines the mechanisms behind the bone tissue damage that may produce the atypical fracture pattern observed increasingly with long-term bisphosphonate use.
This review examines the pathophysiological basis for disease including the importance of the elastin / collagen profile in diverticula formation.
This review examines the publications that explored the utility and efficacy of cognitive intervention in patients with Mild Cognitive Impairment.
This review examines the redox-regulated mechanisms by which cells maintain a functional proteome during oxidative stress.
This review examines the role of EZH2 in normal and malignant hematopoiesis and recent developments in harnessing the therapeutic potential of EZH2 inhibition.
This review examines the significance of this new form of VDAC1 for anticancer therapy.
This review explores four key perspectives of pain management in dementia and makes recommendations for practice and research.
This review explores mechanisms by which the DNA damage response could contribute to metabolic dysfunction.
This review explores mechanisms of mitochondrial dysfunction with a focus on impaired oxidative phosphorylation and mitochondrial biogenesis in the pathophysiology of metabolic heart disease.
This review explores relationships between Mn-dependent neurobiology and Mn-dependent neurotoxicity.
This review explores the chronology of microneedling methodologies , which has led to the emergence of MN devices , now extensively used in cosmeceutical applications.
This review explores the effects of female reproductive hormones , estrogens and progestogens , with a focus on progesterone and allopregnanolone , on object memory.
This review explores the likely consequences of climate change upon the use of medical pharmaceuticals in the Northern Hemisphere.
This review explores the potential roles that the angpts play in the development and progression of AAA and atherosclerosis.
This review explores the relationship between platelet-derived growth factor and wound healing.
This review explores these possibilities focusing on innate immunity , and in particular associations with neutrophil dysfunction , inflammation and known mechanisms described to date.
This review first describes microglial origins and function in the normal central nervous system ( CNS ) , and the changes that occur during aging.
This review focuses first on the impact of ageing on liver morphology and function.
This Review focuses on AGEs as novel initiators of oxidative stress that precedes , rather than results from , diabetes mellitus.
This review focuses on cancers of the lower genital tract , for which the most epigenetic information exists.
This review focuses on chaperone-mediated autophagy ( CMA ) , one of the proteolytic systems that contributes to degradation of intracellular proteins in lysosomes.
This review focuses on co-morbidities in the ageing haemophilia patients , their impact on quality of life and their complex management.
This review focuses on complexity of bone features that could account for increased bone fragility in advanced age.
This review focuses on different copper complexes that are developed from bioactive ligands and mimic the protecting action of the SOD.
This review focuses on exploring the interaction between nrf-2 and ADMA in influencing the nitric oxide pathway and cardiovascular function.
This review focuses on genetic studies of two representative degenerative skeletal disorders : osteoarthritis and degenerative disc disease.
This review focuses on mechanisms responsible for the maintenance of cartilage homeostasis and highlights the role of inflammatory processes in OA progression.
This review focuses on molecular markers and mechanisms implicated in chondrocyte aging and the pathogenesis of OA.
This review focuses on new genetic data in the field of atherosclerosis and arterial homeostasis.
This review focuses on @number@ allergic disorders of persons coming up against venerable age : asthma , allergic rhinitis , and atopic dermatitis.
This review focuses on recent advances in our understanding of the prevalence and types of arrhythmias encountered.
This review focuses on recent advances of mTOR and aging related diseases in hematopoietic and other organ systems.
This review focuses on recent findings of the relationship between perioperative stress and underlying fragility of the brain in cardiac surgical patients.
This review focuses on recent findings that identify autophagy as a critical homeostatic and quality control mechanism maintaining glomerular homeostasis.
This review focuses on redox regulation during skeletal muscle regeneration.
This review focuses on the aging of GABAergic neurons and synapses.
This review focuses on the anti-aging aspects of resveratrol , the possible mechanisms of action , and emerging controversy on its life-prolonging ability.
This review focuses on the association between systolic and diastolic blood pressures and the risk of cardiovascular and renal disease.
This review focuses on the circadian aspects of energy metabolism and their relationship with aging in mammals.
This review focuses on the current status of anti-angiogenesis treatment.
This review focuses on the current understanding of Klotho protein function , with emphasis on its potential involvement in the pathophysiologic process of CKD.
This review focuses on the discovery and development of the first cardiolipin-protective compound as a therapeutic agent.
This review focuses on the effect of age on BAT function as well as BAT as a potential therapeutic target against age-related metabolic diseases.
This review focuses on the effects of collagen crosslinking on bone material properties in health and disease.
This review focuses on the endocrine and physiological features of the transition to menopause , known as the menopausal transition or the perimenopause.
This review focuses on the evaluation and management of common running-related and cycling-related injuries.
This review focuses on the existence of the different alternative splice variants of VEGF and the molecular mechanisms associated with their expression and function.
This review focuses on the fluorescent protein microarrays applied to neurodegenerative disorders , a major health problem in our aging society.
This review focuses on the history of Dysport to mark the 25th anniversary of its first launch in the United Kingdom.
This review focuses on the impact of S-nitrosylation on neurogenesis and neuronal development.
This review focuses on the interaction between chromatin and metabolism in the regulation of tissue stem cells during aging.
This review focuses on the interrelationship between ageing and autophagy.
This review focuses on the key components of the mTOR complex @number@ pathway and on how various stresses impinge upon them.
This review focuses on the key role of FOXN1 in cell development and its clinical implication in humans.
This review focuses on the lamina-independent pool of lamins in the nuclear interior , which surprisingly has not been studied in much detail so far.
This review focuses on the main causes , consequences in terms of morbidity , mortality and costs and treatment of HF.
This review focuses on the most frequent GI disorders of the elderly , describing their epidemiological , pathophysiological and clinical implications.
This review focuses on the @number@ most common filters in commercial and historical use.
This review focuses on the O-GlcNAcylation in basic cellular functions and human diseases.
This review focuses on the osteogenic differentiation of mesenchymal stem cells ( MSC ) , bone formation and turn-over in good and ill skeletal fates.
This review focuses on the pathophysiology of GA , particularly the role of complement cascade dysregulation and emerging therapies targeting the complement cascade.
This review focuses on the pharmacological treatment of behavioral and psychiatric symptoms and disorders in older adults with ID.
This review focuses on the possible relationships between telomere dysfunction and the ( HPA ) axis and GH-IGF-1 system.
This review focuses on the progress made in understanding the physiological function and significance of D3.
This review focuses on the relations of parental age to intelligence , health outcomes , longevity and other characteristics of offspring.
This review focuses on the rich diversity of the satellite cell population based on studies across species.
This review focuses on the role of the venous valves in the genesis of thrombus formation in venous thromboembolic disease ( VTE ) .
This review focuses on these systems and approaches.
This review focuses on the specific pathophysiologic features of PAH in children.
This review focuses on the traditional medicinal uses of Hippocampus species , as well as the phytochemical , pharmacological and toxicological studies on this genus.
This review focuses on trends of HIV-associated cancers in childhood in the HAART era and analyses potential pathogenetic mechanisms.
This review focuses on various therapeutic interventions for gut dysbiosis and gastrointestinal diseases in the elderly.
This review focuses on vitamin D ( @number@ ) , VDR , and macroautophagy in inflammation and infection.
This review focusses on recent studies addressing the complex relationships between depression , aging , inflammation and perfusion deficits in the elderly.
This review follows the Preferred Reporting Items for Systematic Reviews and Meta-analyses ( PRISMA ) statement.
This review gives a general overview of the principles and current evidence for the use of MRI conditional implantable cardiac devices.
This review gives an overview of the traditional CF associated comorbidities and those emerging in an aging adult cohort.
This review has considered studies evaluating physical activity through accelerometers.
This review has enabled us to propose @number@ pairs of tests of the efficiency of working memory capacity in animals and humans.
This review has explored some of the factors that may explain this recent trend within these three main groups.
This review highlights a number of potential pitfalls that should be considered when delivering valued pain relief medicines tailored for the elderly.
This review highlights critical contributions from laboratories working on corneal stromal substitutes.
This review highlights diagnosis and management of the four most widely diagnosed FSDs.
This review highlights evidence for qualitative differences in behavior and physiological correlates of performance monitoring across the lifespan.
This Review highlights pathological commonality , showing that OSA upregulates Aβ , tau hyperphosphorylation , and synaptic dysfunction.
This review highlights recent advances , vital for basic research and clinical drug design , in the regulation of AMPK during fibrosis.
This review highlights selective aspects of protein supplementation in older adults.
This review highlights several methodological challenges involved in research on aging , health , and mortality in adults with rare intellectual disability syndromes.
This review highlights some of the major considerations in planning and implementing this type of study.
This review highlights some of the most current developments in the expanding role of regional anesthesia in foot and ankle surgery.
This review highlights the changing epidemiology of the ageing CF population and the complications that may ensue.
This review highlights the current understanding on the topic of foot orthotics and footwear in adults with rheumatic diseases.
This review highlights the in vivo effects of resveratrol treatment on breast , colorectal , liver , pancreatic , and prostate cancers.
This review highlights the literature surrounding this topic on the prominently studied and documented polyphenols as pertaining to cardiovascular health and aging.
This review highlights the major principles of epigenetic control mechanisms and their link to particular nutritional influences.
This review highlights the priorities to be pursued to enable the proper use of amyloid PET imaging in a clinical setting.
This review highlights the role of nutrition science in promoting healthy aging and in improving the prognosis in cases of age-related diseases.
This review highlights the role of telomeres in aging and describes the lifestyle factors which may affect telomeres , human health , and aging.
This review highlights the synthesis and homeostasis of acetyl-CoA and the regulation of transcriptional and signaling machineries in yeast by acetylation.
This review identified a dearth of research on older Inuit , and highlighted limitations in service provision to this primarily rural and isolated population.
This review identifies region-specific vulnerabilities in astrocyte mitochondria in examples of exposure to neurotoxicants and in age-related neurodegeneration.
This review identifies some of these pitfalls and suggests ideas to circumvent or investigate these hazards.
This review included articles published between @number@ and @number@
This review included @number@ eligible studies.
This review intends to provide a comprehensive picture of the complex role of mammalian peroxisomes in cellular redox metabolism.
This review introduces fungi , the infections they cause , the risk factors involved , diagnosis and treatment.
This review introduces the concept of culture-sensitive health communication.
This review introduces the mechanism of mechanotransduction in the baroreceptor reflex.
This review investigates the current strategies for thymus reactivation to replenish the peripheral T cell repertoire and potentially reverse the age-related inflammatory milieu.
This review investigates these disparities by conceptualizing the dementia disease process as a product of both biological and cultural factors.
This review is aimed at discussing the involvement of autophagy in the pathogenesis of muscle wasting in cachexia.
This review is aimed at researchers interested on the biological consequences of oxidative stress , both at the level of signaling and toxicity.
This review is an attempt to analyze the mechanisms and theories of ageing and achieving longevity.
This review is an attempt to meet that need.
This review is an up-to-date summary of the current state of our appreciation of the above topics.
This review is based on clinical experience and a MEDLINE search for articles about volume replacement and soft-tissue augmentation.
This Review is based on the Franklin Epstein Lecture delivered at Beth Israel Deaconess Hospital on @date@ .
This review is confined to summarizing some of the salient findings of this remarkable compound as they relate mainly to cancer.
This review is devoted to Klotho protein and recent evidences for its functions in the brain.
This review is devoted to the links between atrial fibrillation , cognitive decline and dementia.
This review is focused on the pathophysiology of pes cavus in CMT1A duplication , which is the most common subtype of the disease.
This review is limited by the narrow focus on physical disabilities and two health outcomes.
This review looks at the current literature on distal radius fractures in the elderly and the treatment options for stabilization of these fractures.
This review looks at the risks and the benefits of filtering out short wavelength light in pseudophakic patients.
This review mainly focuses on neural activity and repair roles of VEGF in adult mammalian brains.
This review mainly identifies and discusses the reasons for positive training effects on cognition from clinical and neurophysiological perspectives.
This review might contribute to the development of treatments and / or therapeutic agents that can reduce or eliminate the deleterious effects of alcohol-induced NDD.
This review of pharmacotherapies for the treatment of hand OA focuses on their efficacy and safety in elderly patients.
This review of the current literature focuses first on the normal neuroimmune interactions occurring in the brain , which promote learning , memory and neuroplasticity.
This review operationally refers to this type of metabolism as ' energy metabolism ' or ' bioenergetics. '
This review outlines aspects of CICI consistent with the clinical presentation , biochemistry , and pathology of this disorder.
This review outlines recent advances in AGE research focusing on the mechanisms of their formation and their role in cataract and pathologies of the retina.
This review outlines the epidemiology of clozapine-related adverse effects in older people and discusses potential prevention and management strategies.
This review outlines the present understanding of the role of vitamin E in age-related disease prevention.
This review paper seeks to characterize the downstream effects of ER-α in the hypothalamus and limbic system that affect normal endocrine functioning.
This review points to the neutrophil , and the endothelium as important players in understanding age-associated changes in responsiveness to infectious challenge of the lung.
This review presents an overview of plausible associations between comorbidity , genetics and age-related physiological effects in relation to cancer risk and protection.
This review presents an overview of the evidence for donepezil across the spectrum of AD , with a focus on dose optimization for disease progression.
This review presents an update of our understanding of regulatory ncRNAs contributing to cardiovascular health and disease as a function of advancing age.
This review presents insights from studies of advanced glycation end products ( AGEs ) in humans and mice.
This review presents novel developments in the field of nucleo-mitochondrial communications.
This review presents one potential solution to this paradox by considering what happens to an early memory after it has been forgotten.
This review presents the most important new advances in both topical and systemic photoprotection.
This review presents the potential and actual therapeutic strategies for dementia in relation to the known mechanisms of dementia pathology.
This review primarily focuses on observed associations between LOY in blood and various diseases in aging men.
This review proposes that estrogen and progestogen exposure play an important role in the increased risk of hyponatremia in menopausal women.
This review provides a comprehensive overview of the health impact of ERCC1-XPF deficiency , based on these rare diseases and mouse models of them.
This review provides a comprehensive summary of research on aging-associated alterations in lymphatic vessels and mast cells in perilymphatic tissues.
This review provides a contemporary evidence-based insight into the possible preventative and reverse remodeling role of statins and polyunsaturated fatty acids in AF.
This review provides a historical perspective on research into visual development and the disorder amblyopia.
This review provides an overview of axonal transport pathways and discusses their role in neuronal function.
This review provides an overview of microbial etiology , resistance patterns , epidemiology and microbial diagnosis of pneumonia.
This review provides an overview of the changes in RAS with aging and age-disease interactions culminating in the development of frailty.
This review provides an overview of the current state of our knowledge of the genetic basis of menarche and menopause timing.
This review provides an overview of the interaction between the mammalian cholinergic system and circadian system , and its possible role in time memory.
This review provides an overview of the last five years about the potential of coumarins as modulators of several physiological mechanisms involved in age-related pathologies.
This review provides an overview of the major artifacts in CT and MRI and state-of-the-art solutions to improve image quality.
This review provides an update on the brain-related specificities and dysfunctions of this pathway and discusses the autophagy-based therapies couteracting neurodegeneration.
This review provides examples of some major unresolved clinical problems encountered in daily cardiovascular practice as we care for elderly patients.
This review provides recent data supporting this concept.
This review provides recent research advances dealing with molecular mediators modulating muscle mass in both sarcopenia and cachexia.
This review recapitulates several studies evaluating the effect of in vitro and in vivo MSC aging on cell properties.
This review recounts the established roles of TNAP and IAP and briefly discusses new areas of investigation related to multisystemic functions of these isozymes.
This review recounts the way that C. elegans can be used to investigate various aspects of genetic and molecular nephrology.
This review reports the micronutrient-gene interactions in ageing and their impact on the healthy state with a focus on the method of protein-metal speciation analysis.
This review reports the present knowledge on the in vitro and in vivo studies concerning the use of thymosin alpha @number@ in HIV-1 infection.
This review seeks to provide a counter-rationale for testosterone therapy in LOH.
This review shall shed light on complex neurobiological mechanisms that underpin late life depression and help to better understand neural correlates of resilience.
This review should assist investigators in choosing suitable methods to assess spatial memory in mice.
This review showed an overall pooled prevalence of frailty among Japanese community-dwelling older people of @percent@.
This review showed that assisted reproduction technologies ( ARTs ) continue to have low live-birth rates in women over @number@
This review shows that adequate O2 provision to the active tissues is critical in the dynamic adjustment of oxidative phosphorylation even in young healthy individuals.
This review shows that LCPUFA are essential throughout life.
This review shows that many of these measures have good psychometric properties , and appear to have at least moderate sensitivity.
This review suggests that insulin , age at diagnosis , and weight play a role in ovarian dysfunction.
This review summaries the dietary sources and bioactivities of melatonin , with special attention paid to the mechanisms of action.
This review summarises a sample of the most promising efforts to deliver the products of ageing research to the clinic.
This review summarises available evidence from the medical literature on the efficacy and safety of fesoterodine in elderly patients with OAB symptoms , including UUI.
This review summarises current non-pharmacological practices and intervention options to aid healthy children sleep.
This review summarises recent advances in understanding the role of Lp in the induction of endothelial dysfunction and the initiation and progression of atherosclerotic lesions.
This review summarises the available data on blood coagulation and fibrinolysis in AS with the emphasis on their interactions with inflammation and calcification.
This review summarized the recent development in trying to understand the regulation of melanocyte and melanocyte stem cells.
This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases ( CVDs ) .
This review summarizes anatomy , physiology , and pathophysiology of these joints and the sensory pain relays.
This review summarizes and discusses the roles and potential mechanisms of gut bacteria in human health and diseases.
This review summarizes available evidence regarding the impact of delaying childbearing on fertility and pregnancy outcomes.
This review summarizes common de novo malignancies occurring in the post liver transplant population and current strategies for their prevention and management.
This review summarizes comprehensive recent findings on the beneficial actions of cocoa-driven phytochemicals in molecular mechanisms of human health.
This review summarizes current findings about zinc deficiency and supplementation in elderly individuals.
This review summarizes current knowledge of natural polyphenols , including resource , bioactivities , bioavailability and potential toxicity.
This review summarizes current knowledge regarding VASH1 in terms of its roles in maintaining vascular integrity and protecting the vasculature against various forms of stress.
This review summarizes currently known Runx functions in the stem cells of these tissues.
This review summarizes current research detailing the known parts of the erythrocyte storage lesion and their physiologic consequences.
This review summarizes efforts to translate ORT to use in female cancer patients.
This review summarizes evidence from several longitudinal population-based birth-cohort studies that have identified risk factors for persistence and remission of childhood asthma.
This review summarizes findings of the last year , which shed new light on mechanisms and factors involved in cartilage loss.
This review summarizes key outcomes of the conference.
This review summarizes ongoing investigations into clinical and basic science studies on RBC storage effects.
This review summarizes our current knowledge of the molecular chaperone system and its role in protein homeostasis.
This review summarizes our current understanding of IVD physiology and the complex cell-mediated processes that contribute to IVD degeneration.
This review summarizes physiological and functional changes due to chronic dementia caregiver stress.
This review summarizes recent advance in the investigation of Ral GTPases.
This review summarizes recent developments of oncological therapy in the palliative setting of metastatic pancreatic ductal adenocarcinoma.
This review summarizes technical advances toward the generation of potentially clinically relevant human iPSCs.
This review summarizes the current bioavailability data , focusing on data from humans , and provides suggested directions for future research in this realm.
This review summarizes the current definition of a marginal donor and provides some suggestions for clinical management of these particular kidney transplants.
This review summarizes the current knowledge of p53 and of the interconnection between p53 and DUBs.
This review summarizes the current knowledge of senescence induction in response to these stressors and their relation to the comorbidities in HIV patients.
This review summarizes the current knowledge of TTR-RBPs that influence renal metabolism.
This review summarizes the current knowledge regarding the formation of mtDNA mutations and their impact on mitochondrial function.
This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality , reproductive success and offspring health.
This review summarizes the current status of PTMs by UBLs in the DDR and their implication in cancer diagnosis , therapy and drug discovery.
This review summarizes the current understanding of how cellular and systemic energy metabolism regulate neural stem cell fate.
This review summarizes the current understanding of molecular mechanisms , functions , and clinical applications of cellular senescence for anticancer therapy.
This review summarizes the data and mechanisms of action of melatonin in relation to mitochondrial pathologies.
This review summarizes the findings of a joint workshop sponsored by the NIA and NHLBI that brought together investigators focused on aging and lung biology.
This review summarizes the general function of the immune system and its regulatory mechanisms in the vitreoretinal compartment.
This review summarizes the literature regarding the role of OS and premature placental ageing in the pathophysiology of pregnancy complications.
This review summarizes the major factors responsible for premature skin ageing and the plants being targeted to lessen the impact of those.
This review summarizes the many results derived from the GHR- / - mice.
This review summarizes the mechanisms of action and therapeutic potential of SS-31 and provides an update of its clinical development programme.
This review summarizes the over @number@ publications using ADNI data during @number@ and @number@
This review summarizes the progress about Wnts function in mature nervous system with a focus on Alzheimer's disease ( AD ) .
This review summarizes the progress and hotspots in recent researches of the associations among gut microbiota , the immune system , osteoporosis.
This review summarizes the recent INSL3 literature published within the last 12-18 months.
This review summarizes the recent literature in the field of vasopressin signaling in age-dependent abnormalities in kidney , cardiovascular function , and bone function.
This review summarizes the recent literature on the nutritional pathways to frailty with particular focus on the effect of energy , protein and micronutrients.
This review summarizes the recent literature showing the associations between different nutrients and mobility-related outcomes in older adults.
This review summarizes the recent progress on mPTP and its potential therapeutic target for neurodegenerative diseases including AD.
This review summarizes the regulatory circuits mediated by the activation of FOXO , which in turn modulate Akt and TORCs activities.
This review summarizes the role of free radicals and oxidative stress in developing aging in kidney and human pathologies.
This review summarizes the roles of sphingosine kinase signaling in these processes and the mechanisms mediating these responses.
This review summarizes what is known about SCS in the kidney with aging and disease.
This review summarizes work linking the ability to regulate intracellular ROS to the hematopoietic stem cell phenotype , aging , and disease.
This review tackles these questions.
This review takes a critical look at these approaches and highlights the application and limitations of these proposed methods.
This review takes the example of neuroimmunology research and the microglia cell type to illustrate the emerging differences between rodent and human research findings.
This review therefore describes the main advances in techniques for breaking the spore wall and extracting biocompounds from the spore.
This review traces evidence that age-related dementia ( Alzheimer's disease ) results from the destructive impact of the pulse on cerebral vasculature.
This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD.
This review uses several model examples that will be of interest to leukocyte and cell biologists alike.
This review was conducted to investigate the effects of melatonin on female reproduction and to summarize our findings in this field.
This review was conducted to summarize existing evidence to test the hypothesis that obesity is a risk factor for bone health in aging individuals.
This review was designed to review current and recently updated information on the epidemiology of urinary incontinence in men.
This review was registered on PROSPERO ( CRD42016035978 ) .
This review was registered with PROSPERO under DIO : @number@.15124 / CRD42015027046.
This review will address the current understanding of the relationship between ageing and several factors both genetics and life style related.
This review will aid in the understanding of each step of the diagnosis and treatment of acetabular defects in revision total hip arthroplasty.
This review will aim to examine the uncertainty regarding the nature and the clinical importance of the age-related reduction in the testosterone levels.
This review will also describe several methods that have been recently advocated to silent the activity of these endogenous proteases.
This review will cover current understanding of the condition and discuss clinical features , research strategies and future directions.
This review will cover recent progress in our understanding of the role of ubiquitylation in the regulation of DNA repair.
This review will cover these topics and suggest that strategies to maintain sirtuin activity may be on the horizon to forestall diseases of aging.
This review will discuss about transdermal bio-identical progesterone cream as suggested hormonal treatment of OA , based on its pathogenic process.
This review will discuss proper patient analysis and selection for aging face surgery , including medical , anatomic , and psychosocial factors that are involved.
This review will discuss the paracrine actions of PVAT on the growth of underlying vascular smooth muscle cells ( VSMCs ) .
This review will discuss the recent advances in the understanding of the association of several adipokines with common obesity-related cancers and the clinical therapeutic implications.
This review will examine available experimental evidence across commonly studied experimental species for developmental programming of female and male reproductive function throughout an individual's life-course.
This review will examine available recommendations and explore those controversies regarding non-ICU hospital management in this vulnerable patient population.
This review will examine the literature in relation to potential mechanisms associated with cognitive decline in BD.
This review will examine the relationship between heritable genetic and epigenetic influences on thoracic and abdominal aortic aneurysm formation and rupture.
This review will examine the role of menopause transition and associated decrease in hormonal status with regards to those changes.
This review will explore the clinical and pathological findings of the various forms of Creutzfeldt-Jakob disease ( CJD ) .
This review will focus on estrogen and inflammation and its interaction with aging.
This review will focus on glomerular hemodynamics , and on renal sodium and potassium handling and diluting and concentrating ability.
This review will focus on how the aging immune system may contribute to COPD development later in life in susceptible individuals.
This review will focus on involvement of LCPUFA from genesis to senescence.
This review will focus on the distribution of memory cells in the different immunologic compartments of Rhesus macaques.
This review will focus on the impact of dysregulated production of IL-1β on hippocampus dependent-memory systems and associated synaptic plasticity processes.
This review will focus on the linking mechanisms between cellular senescence , telomere shortening , and AD.
This review will focus on the relationship among these different medical situations , trying to clarify the cellular and molecular mechanisms.
This review will focus on the role of Nrf2 in these diseases and the potential for Nrf2 activation to attenuate disease progression.
This review will focus primarily on the effect of aging on the human hematopoietic stem cell ( HSC ) population.
This review will give a detailed overview of the complications secondary to cutaneous collagen injections.
This review will highlight some metabolic and physiological factors such as ageing and apoE polymorphism that influence DHA homeostasis.
This review will outline the important contribution of splicing regulator proteins to ageing and age-related disease.
This review will primarily focus on the alterations of metal homeostasis that are observed in normal aging and in Alzheimer's disease.
This review will provide an overview on medications currently available for management of both motor and nonmotor symptoms of Parkinson's disease.
This review will provide available evidence of the diverse impacts of drug medications on functional status in older persons.
This review will summarize and discuss current concepts regarding the mechanisms behind aberrant DNA methylation in cancer and specifically AML.
This review will summarize and highlight the most promising screening tools including neuropsychometric , clinical , blood , and neurophysiological tests.
This review will summarize clinical studies evaluating this topic.
This review will summarize key findings on how aging impacts immunity to viral infection.
This review will summarize recent advances in cell transplantation for dry AMD.
This review will summarize several notable strategies and representative examples of drug repositioning for AD.
This review will summarize the current knowledge about the cellular functions and post-translational regulation of the dual-targeted protein TERT.
This review will thus summarize recent progress in this emerging area of metabolic research.
This review will undertake an explanation of the current literature on this topic.
This rise was neither explained nor investigated in @number@ cases.
This risk at least doubles with the presence of a first-degree relative with the disorder.
This risk estimate was consistent across locations and stages of CRC ( range of ORs , @number@ @date@ ) .
This risk explains the @number@ year shorter life expectancy of the e4 carriers compared to the non-carriers in this sample.
This risk is attenuated by BMI.
This risk is thought to be mediated , in part , through the mechanism of stiffening of the arteries.
This risk reached @number@ ( @number@.43-21.96 ) when two major diminished-function variants were present.
This role , however , has received little attention in research.
This role promotes a socially active lifestyle that may be beneficial to cognitive ageing.
This rule identifies a primary event from a neuropathological effect generated by the disease process.
This sample consisted of @number@ clients from Europe , Canada , and the United States.
This sample was @percent@ male , @percent@ white , @percent@ black , @percent@ Asian , and @percent@ Hispanic.
This sample was stratified into groups according to habitual physical activity ( PA ) and matched with @number@ controls.
This scale is of practical value for the promotion of long-term community care aging in local policies.
This scale talks about functional independence and engagement.
This scenario does not fit easily with the age demarcations that are in place in acute care facilities.
This screen identified @number@ phosphatidylcholine ( PC ) molecules that were significantly diminished in AD cases.
This screening led to the identification of a set of bioactive compounds that impair the APE1 / NPM1 association in living cells.
This screening process yielded improved quality results but also identification of previously undetected visual deficits.
This secondary analysis included @number@ Black ( @percent@ ) and White ( @percent@ ) older Medicare-Medicaid enrollees.
This seems at odds with the assumption that further recovery is unlikely and the subsequent lack of resources devoted to chronic stroke rehabilitation and management.
This seems relevant for clinical prognosis and therapeutic strategies.
This seems to be mediated , in part , by oxidative stress , particularly during the late perimenopausal and postmenopausal periods.
This seems to have overshadowed the significance of wounds per se as a major health problem.
This seems to suggest that MW becomes less frequent with aging , but more pervasive and detrimental to performance.
This segmental progeria differs from natural aging , and implicates p53 overexpression in the etiology of CS.
This selective nonresponse results in an overoptimistic view of aging populations , particularly for the very old.
This selective review will emphasize the need for considering axonal transport when interpreting functional consequences of inter-individual variations in the structural properties of white matter.
This semantization effect is attributed to a loss of episodic memory ability.
This sensing of the environment and consequent cellular responses are orchestrated by a multitude of signaling pathways and typically involve changes in transcription and metabolism.
This sequence includes CHEC-9 , an orally available anti-inflammatory and cell survival peptide.
This sequence of events would explain why therapies and vaccines that eliminate amyloid plaques have been unsuccessful in stopping dementia.
This sequence promotes both types of diabetes mellitus.
This seriously hampers realistic extrapolation of preclinical findings to the general population affected by cancer.
This serum sex hormone showed a significant increment after the age of @number@ years.
This service-learning experience also demonstrated the need for gerontological nursing education in SA.
This session summary captures the discussions and presentations that transpired during this session.
This setup allows us to identify the effect of expected and desired as well as the effect of unexpected additional children on mental health.
This sharing contributed strongly to their sense of emotional stability and effectiveness in solving problems.
This sheds light on the important role of isolation , especially in elderly females , as a pathogenic factor in late-onset paranoic state.
This shift along the posteroanterior axis was only present in the SWA frequency range and remained stable across the night.
This shift is often described as a compensatory recruitment of prefrontal regions due to age-related sensory-processing deficits in posterior regions.
This shift may increase the brain's vulnerability to lower BP in subjects with vascular disease.
This shift was most pronounced in elderly transplant patients under immunosuppressive therapy.
This shortage is worse than that at the national level , and more marked along the Texas-Mexico border and counties lacking large health facilities.
This short article briefly describes the research missions of the AHRQ , NIA , and VA.
This short communication summarizes the findings by the authors and highlights the seemingly paradoxical roles of IFN type I and type II in neuroinflammation.
This shortening is compensated by the enzyme telomerase.
This short review briefly summarizes the current understanding of reproductive aging , as well as its potential clinical and anthropological impact.
This short review summarizes the current state of knowledge to provide an overview and rationale for clinical decision making.
This should aid progress towards a more uniform operationalization of multimorbidity.
This should apply both to clinical studies and to basic science research.
This should be addressed within the Irish authorities ' plan to improve safety and equality for older people.
This should be considered in diagnostic evaluation of biomarkers , and for better clinical stratification of patients.
This should be considered when developing estimates of medical costs and implementing prevention activities.
This should be kept in mind when performing stable isotope studies in this population.
This should be taken into account , particularly when ASSRs are used in clinical practice , comparing patients and healthy subjects.
This should be taken into account when assessing the epidemiology of human rickettsioses and their impact on public health.
This should be taken into consideration when disease is diagnosed.
This should help to define subgroups of patients based on pain phenotype , for more adapted treatment.
This should include greater social protection , age-appropriate health services , and modification and control of cardiovascular risk factors.
This should lead to an increase in availability of diagnostic tools and the enthusiasm for pharmacological companies to develop drugs for sarcopenia.
This should overcome a potential reduced vaccine protection due to mismatches between TIV and circulating B viruses.
This should result in discovery of biomarkers , typical for each source of anemia.
This shows that even at such low levels the possible effect of cadmium on kidney function was present and measurable.
This shows that larger RT differences were associated with larger reductions in P3 peak amplitudes in the stop-signal blocks relative to the pure choice blocks.
This shows that the recruitment of intracellular A2AR signaling in the hippocampus is sufficient to trigger memory dysfunction.
This shows that wrinkled-skin fi broblasts have the ability to reorganize collagen but that the extract can reactivate this latent potential.
This shows the complexity of T cell phenotype and fine autoreactive specificity in responses to NC16A , in patients and in normal controls.
This shows the OG rely on hip flexors to propel the leg into swing when ankle plantar-flexor function is reduced.
This signaling network may coordinate multiple pathways acting upon immune , inflammatory , regenerative , and metabolic processes.
This significance was maintained at @number@ weeks.
This signifies that the treatment transforms HIV infection from a chronic infection to a chronic inflammatory disease.
This signifies the potential role of the UPR cascade in modulating the final phenotype in patients with collagen IV nephropathies.
This simple tool does not require nutrient analysis , and has the potential to be of value to non-specialist researchers.
This simple visual classification system was capable of providing information on vascular risk factors and CVD markers by simply rating WMH on magnetic resonance imaging.
This simulation study applies to a Japanese hypothetical cohort with implications for other super-aged and aging societies abroad.
This single treatment markedly extended survival.
This sirtuin also exerts important systemic effects via the hypothalamus.
This sirtuin also plays a role in memory formation by modulating synaptic plasticity.
This site-dependent difference in sympathetic innervation would reflect its commitment to muscle activity.
This site effect supports the hypothesis that the greatest decrement in pain sensitivity associated with aging occurs in the lower extremities.
This situation can lead to a number of serious diseases such as tumors.
This situation is especially alarming for interventions that are usually standard clinical practice ( repositioning , support surfaces ) .
This situation led to a decrease in the number of pharmacists who are experienced in home care.
This situation results in deleterious effects due to an attentional overload.
This slowing in US compared to LS does not appear to be related to local O ( @number@ ) availability.
This small pilot study is the first to examine the relationship between cortisol , catecholamines and LTL specifically in un-medicated MDD in comparison with HC.
This small size fish is a unique alternative non-mammalian vertebrate model for studying estrogen-related molecular regulation in postmenopausal skeletal disorders in vivo without ovariectomy.
This SnapShot focuses on the role of cellular senescence in health , disease , and aging.
This SnapShot provides an overview of these properties , with an emphasis on their relevance to aging.
This SNP is one of a cluster of highly correlated variants , including rs865686 , that spans ∼14.5 kb.
This SNP , rs2075650 , is located in TOMM40 at chromosome 19q13.32 close to the apolipoprotein E ( APOE ) gene.
This so-called ' anabolic resistance ' represents a key factor responsible for the age-related decline in skeletal muscle mass.
This so-called anorexia of aging predisposes elderly people to continued pathologic weight loss and malnutrition-major causes of morbidity and mortality.
This so-called bilateral deficit may be reduced or counteracted by long-term practice.
This so called H-reflex conditioning technique allows one to assess excitability of the fastest ( monosynaptic ) and also polysynaptic corticospinal pathways.
This social innovation has been implemented in many countries in recent decades to address the aging of the population and associated pandemic of chronic diseases.
This social work education framework can be replicated in an effort to infuse gerontology content throughout other disciplines.
This software is distributed under an open source license at the following URL : @url@
This somatic instability has compromised attempts to measure intergenerational repeat dynamics and infer genotype-phenotype relationships.
This special issue contains seven original contributions that address these issues.
This special issue describes the preliminary findings of the Candrive / Ozcandrive prospective study of @number@ older drivers in Canada , Australia and New Zealand.
This special issue of Ageing Research Reviews focuses on advances in research on the immunology of human ageing.
This special issue of the Journal of Clinical Neurophysiology is dedicated to exploring the electrophysiology of these conditions.
This special issue showcases research from around the world that takes a functional approach to autobiographical remembering.
This special section reflects an important movement in aging research to examine couples as an alternative but normatively common unit of analysis.
This spongiform change begins several months before clinical onset , and is followed by gliosis.
This spotlight offers a unique window into factors affecting aging in Lebanon.
This stage of the disease is potentially reversible.
This state is also observed with increased oxidative stress and inflammation , suggesting that the antioxidant function of MTs has been impaired.
This statement is also true for research laboratories working in the field of nutrition and aging.
This statement reviews biochemical / cellular pathways involved in facilitating and abrogating microvascular injury.
This state of affairs may contribute to the increased incidence of adverse events and poor patient outcomes.
This state of altered brain immunity may lead to the increased brain vulnerability to viral infections , primoinfection as well as reactivation.
This stem cell phenotype was partially corrected by NAC treatment.
This stems from their roles in the stability of telomere structure and in the inhibition of DNA damage response at telomeres.
This stiffness imbalance may cause crystal-induced dysregulation of chondrocyte mechanotransduction promoting both aging and osteoarthritis chondrocyte phenotypes.
This stochastic dynamics approach opens up new ways to understand and potentially treat the effects of normal aging on memory and cognitive functions.
This strategy enabled them to reach a level of end-point performance comparable to the young adults ' performance.
This strategy has provided excellent outcomes even when kidneys from donors older than @number@ years have been used.
This strategy led to the identification of several direct NF-κB inhibitors.
This strategy may be most effectively applied in a clinical trial of primary prevention.
This strategy relies on the multidimensional modeling of complementary biomarkers to cope with the phenotypical and pathophysiological complexity of PF and sarcopenia.
This strategy to successfully initiate and maintain joint attention is related to language development as it increases learning opportunities from social interactions.
This strategy would also enable us achieve our goal of eliminating avoidable blindness due to cataracts by the year @number@
This strategy would not only be beneficial for improved blood pressure control but would also contribute to the general prevention of non-communicable diseases.
This stress shielding may contribute to bone loss in the vertebral body , leading to increased fracture risk.
This STR locus is also widely used in forensic genetics.
This study addresses the prevailing gap in knowledge through direct consultation of older persons in the community about their perceptions of elder abuse.
This study addresses whether early exposure to healthy older adults through the humanities may prepare medical students for positive relationships with aging patients.
This study adds to accumulating evidence of the value of telomere length , as an early biomarker of AD progression in adults with Down syndrome.
This study adds to our understanding of the interaction between MMPs and IVDD.
This study adds to the evidence that CTSD increases the risk of AD , although the effect size is moderate.
This study adopted a time-geographic method and occupational perspective to explore the occupational engagement of community dwelling older people.
This study aimed at analyzing the relationships between chronic conditions , disability , and QoL of older adults with multimorbidity in Spain.
This study aimed at assessing the clone-forming efficiency ( CFE ) of hHF keratinocytes from three age groups of human donors.
This study aimed at assessing thrombin generation in adults and its correlation to classical rotational thromboelastometry ( ROTEM ) .
This study aimed at exploring ways of being happy in older adults in Chile.
This study aimed at identifying aging phenotypes and their related outcomes in order to recognize frailty in hospitalized older patients.
This study aimed at identifying characteristics associated with anticoagulation underuse.
This study aimed at investigating antithrombotic therapy status in elderly patients with NVAF in our hospital.
This study aimed at investigating how participants perceived this kind of initiative and how they reacted to different kinds of ICTs.
This study aimed at investigating how retinal anatomic structures relate with the spatial MPOD distribution in single eyes.
This study aimed at investigating the association between alcohol consumption and MI considering time-varying alcohol consumption and time-varying confounders.
This study aimed at the assessment of the validity and reliability of the self-made questionnaire on knowledge and attitude of general practitioners about andropause.
This study aimed at understanding the neural mechanisms underlying the development of attention functions during childhood.
This study aimed at validating the MTL / memory and FL / executive functions indexes in French-speaking adults.
This study aimed to address the research gap of this association among U.S. Chinese aging population.
This study aimed to address this issue.
This study aimed to analyse the subjective burden of family carers of people with early and advanced COPD and its predictor variables.
This study aimed to analyze the relationship between CAR and hPER1 gene expression with respect to human aging.
This study aimed to assess chronic pain therapy with regard to the interaction potential in a sample of inpatients with multiple chronic conditions.
This study aimed to assess the benefit of adding physical function evaluations and interventions to routine elderly health examination.
This study aimed to assess the effect of inclusion of a pharmacist on a physician-led ward round on potentially inappropriate prescribing in hospitalized elderly patients.
This study aimed to assess the gender-specific influence of muscle mass on bone and metabolic parameters.
This study aimed to assess the impact of nutrition screening and intervention on these parameters.
This study aimed to assess the lifetime risk of CVD and the impact of risk factors on lifetime risk of CVD in Chinese population.
This study aimed to assess the relationship between declines of normal ageing-related kidney function and cardiac diastolic function in a healthy Chinese population.
This study aimed to assess uptake and decision making for predictive genetic testing and the impact on psychological well-being.
This study aimed to calculate the incidence of AKI due to anti-TB drugs and analyze the outcomes and predictors of renal recovery.
This study aimed to characterise differences in the resting platelet proteome and the platelet releasate of healthy children compared to healthy adults.
This study aimed to characterize the mechanical properties of aged human anterior mitral leaflets ( AML ) and posterior mitral leaflets ( PML ) .
This study aimed to clarify age-related differences in psychosocial functioning in ACHD patients and determine the factors influencing anxiety and depression.
This study aimed to clarify how dialysis patients utilize the services covered by Japan's public long-term care insurance ( LTCI ) system.
This study aimed to clarify the age-level difference of hand grip power in females.
This study aimed to clarify the age-specific risks affecting the short-term outcome after isolated coronary artery bypass grafting ( CABG ) .
This study aimed to clarify the efficacy , safety , and pharmacokinetics of piperacillin tazobactam ( PIPC TAZ ) in late elderly Japanese patients.
This study aimed to clarify the status of surgeries for ASD in Japan , focusing on perioperative complications.
This study aimed to compare anticoagulation practice in Australia during the pre- and postdirect oral anticoagulant ( DOAC ) eras.
This study aimed to compare hypoglycaemia rates between insulin degludec ( IDeg ) and insulin glargine ( IGlar ) in elderly patients.
This study aimed to compare positive mental health between elderly and young earthquake survivors.
This study aimed to compare the effects of MCT and RT programs on metabolic health parameters in healthy elderly.
This study aimed to compare the prevalence of frailty across three Chinese populations : Hong Kong , Taiwan-urban and Taiwan-rural.
This study aimed to compare the static balance control of @number@ KTRs with @number@ healthy adults ( HA ) .
This study aimed to compare the tear antioxidant content and flow rate in young and older adults.
This study aimed to comprehensively elucidate the association of common genetic variants in FOXO3 with human longevity in a Chinese population.
This study aimed to construct an IADL scale with an extended range.
This study aimed to correlate the aorta-sacral promontory distance with age.
This study aimed to critically evaluate the efficacy and safety of statins for primary prevention of cardiovascular disease ( CVD ) in the elderly.
This study aimed to define age- and comorbidity-related normative values in ADL.
This study aimed to describe the cognitive and functional abilities of solitary-living AD patients , and the potential predictors of their usage of community-based services.
This study aimed to determine cancer incidence in the frail relative to non-frail community resident older adults.
This study aimed to determine national trends in prevalence , discharge disposition , length of stay , and cost of subdural hematoma over time.
This study aimed to determine the correlates of depression among a community based elderly population.
This study aimed to determine the effect of ageing on cardiorespiratory and tissue oxygenation responses to hypoxia during maximal incremental exercise.
This study aimed to determine the effects of age and myopic astigmatism ( MA ) on the corneal shape factors in the Hong Kong Chinese.
This study aimed to determine the onset and persistence of disabling foot pain in community-dwelling older adults over a 3-year period.
This study aimed to determine the prevalence of frailty and its association with adverse outcomes in community dwelling older adults.
This study aimed to determine what factors were associated with achieving adequate hearing aid self-efficacy.
This study aimed to determine whether aging affects circulating interleukin-6 ( IL-6 ) levels.
This study aimed to determine whether an increase in fat and energy intake modifies the suppressive effects of CCK-8 on appetite and energy intake.
This study aimed to determine whether associations between the perceived environment and physical activity are moderated by urban-rural status among midolder aged adults.
This study aimed to determine whether the phenotype of familial longevity is marked by a relative preservation of brain tissue microstructure.
This study aimed to develop and validate a Polynesian version of the MMSE ( Mini-Mental State Examination ) .
This study aimed to develop and validate such a method for delirium detection using routine medical records in UK and Ireland.
This study aimed to document and compare the decline of upper limb performance among adults with myotonic dystrophy type @number@ according to phenotype and gender.
This study aimed to evaluate associations of household income and wealth with both prevalent and incident diabetes among older adults in the UK.
This study aimed to evaluate changes in voiding with age in women with different urodynamic diagnoses.
This study aimed to evaluate potential attention deficits not previously described in these patients.
This study aimed to evaluate quadriceps femoris rate of force development and quantify potential central and peripheral activation deficits in individuals with Parkinson disease.
This study aimed to evaluate the acute ketogenic effect of @number@ doses of caffeine ( @number@ @number@ mg / kg ) in @number@ healthy adults.
This study aimed to evaluate the all-cause mortality rates and adverse health outcomes among older adults with new-onset diabetes mellitus through a nationwide population-based study.
This study aimed to evaluate the clinical features , incidence and risk factors of stroke and bleeding in elderly AF patients.
This study aimed to evaluate the effectiveness of an innovative exercise program on muscle strength , balance , and gait kinematics in elderly community-dwellers.
This study aimed to evaluate the effectiveness of once weekly CST and determine any additional impact when enhanced with a carer training program.
This study aimed to evaluate the effect of cognitive load on both simple and complex postural tasks.
This study aimed to evaluate the immunogenicity of VrHB-IB in adults over @number@ years of age.
This study aimed to evaluate the impact of old age on the surgical outcomes of totally laparoscopic gastrectomy for gastric cancer.
This study aimed to evaluate the impact of trained volunteer mealtime assistants on the dietary intake of older inpatients.
This study aimed to evaluate the incidence and risk factors of repeat vertebral augmentation.
This study aimed to evaluate whether subjective assessments of unmet need may complement conventional methods of measuring socioeconomic inequity in health care utilization.
This study aimed to examine and compare the cognitive performance of non-demented older community dwellers with and without MCR and MCI syndromes.
This study aimed to examine experiences of discrimination and responses to unfair treatment among community-dwelling U.S. Chinese older adults.
This study aimed to examine how the prevalence of EM and its subtypes vary using different definitions among U.S. Chinese older adults.
This study aimed to examine QOL in relation to the sociodemographic and clinical characteristics of adults aged ≥50 years in Macao.
This study aimed to examine the association between alcohol and brain structure measured with MRI.
This study aimed to examine the association between filial piety and suicidal ideation among U.S. Chinese older adults.
This study aimed to examine the association between polysomnographic sleep and subjective habitual sleep quality and restoration from sleep.
This study aimed to examine the associations between elder abuse and risk for metabolic syndromes.
This study aimed to examine the associations of positive and negative partner interactions and social networks with depression , anxiety and suicidal ideation.
This study aimed to examine the cross-sectional association between self-neglect and cognitive function.
This study aimed to examine the efficacy of creatine supplementation , associated or not with resistance training , in vulnerable older women.
This study aimed to examine the functional connectivity within DMN , and its diagnostic value with age-related morphometric alterations considered.
This study aimed to examine the prevalence of lipid and lipoprotein abnormalities by recently updated menopausal stages in middle-aged women.
This study aimed to examine the relationship between modifiable risk factors and hippocampal volume in older adults at risk of cognitive decline.
This study aimed to examine the relationship between the severity of WMHs and LOS in patients with cognitive impairment.
This study aimed to examine the relationships between adiposity , ageing and skeletal muscle size and architecture.
This study aimed to explore experiences and perceptions of life with chronic pain among older Japanese adults in the community.
This study aimed to explore the association between SCH and lipid profiles in different age groups.
This study aimed to explore the effect of various cell phone functions on postural control and mobility in the elderly.
This study aimed to explore the efficacy of mindfulness training in improving stress-related outcomes in family caregivers of people with dementia using a meta-analytic review.
This study aimed to explore the in-depth clinical reasoning of nonoccupational therapists using Algo to pinpoint the items leading to disagreements regarding recommendations.
This study aimed to explore time-to-death-related effects in measures of affect in a sample of the very old.
This study aimed to explore whether the prospective associations between exercise and subsequent depressive symptoms were distinct between APOE-e4 carriers and non-carriers using nationwide data.
This study aimed to extend the previous knowledge on risk factors for delirium and the consequences.
This study aimed to fill this gap.
This study aimed to further determine the treatment effects of the MT + MG approach on muscular properties , sensorimotor functions , and daily function.
This study aimed to identify and analyze the relations between aging and work.
This study aimed to identify EEG characteristics that might warn of awakening ( AW ) from sevoflurane anaesthesia in infants.
This study aimed to identify LS trajectories in older adults and the characteristics of individuals who experience them.
This study aimed to identify novel genes that interact with ever active tobacco smoking in adult onset asthma.
This study aimed to identify some specific regions with high relative risk , and this information is useful for the health administrators.
This study aimed to identify the current level of diabetes care in NHs using a mixed methods approach.
This study aimed to investigate DNA repair genes expression in human lens cortex collected from age-related cortical cataract ( ARCC ) and controls during surgery.
This study aimed to investigate longitudinal respiratory function and symptoms in older , non-smoking , long-term officially-acknowledged victims of pollution-related illness.
This study aimed to investigate potentially modifiable determinants of vitamin D levels in young adults in Korea.
This study aimed to investigate QoL and its related factors among Chinese older people who live alone.
This study aimed to investigate sex and age effects on 5-HT ( @number@ ) receptor-binding potentials in striatum , the limbic system , and neocortex.
This study aimed to investigate the 25-hydroxyvitamin D levels in postmenopausal women living in Tehran , capital of Iran.
This study aimed to investigate the association between the marital status of offspring aged @number@ years and over and the depression levels of parents.
This study aimed to investigate the causes of overtriage and to provide suggestions for future amendments to such systems.
This study aimed to investigate the cigarette smoke-induced pathological changes in brains.
This study aimed to investigate the contributions of age and depression severity to sleep-wake disturbances.
This study aimed to investigate the difference of renal function and Klotho gene polymorphisms between Kazak and Uygur normal populations in Xinjiang , China.
This study aimed to investigate the hemodynamics in patients undergoing LEMG and determine the risk factors for hemodynamic changes.
This study aimed to investigate the hypothesis that chronic low-level head trauma is associated with persistent cognitive decline.
This study aimed to investigate the impact of TCP on patients according to their cognitive status.
This study aimed to investigate the involvement of age-dependent CFTR downregulation in lowering sperm quality in old age.
This study aimed to investigate the possible models of the fractal dimension changes from young to old subjects ( 10 73 years ) .
This study aimed to investigate the protective role of RES against mitochondrial dysfunction and human nucleus pulposus cell ( NPC ) apoptosis.
This study aimed to investigate the relationship between MCI and oxidative stress biomarkers in OSAHS.
This study aimed to investigate the safety of zolpidem administration in extremely old elderly.
This study aimed to investigate whether baseline biological , psychological and social aproaches to successful ageing predicted future QoL.
This study aimed to investigate whether the impact of comorbidity on QoL is lower in older home care clients with positive attitudes toward aging.
This study aimed to manage some lower GI-NMS in a group of patients with PD.
This study aimed to predict clinical failure by identifying these prostate cancer-related genes.
This study aimed to predict the risk of falls by focusing on substance abuse in the elderly with dementia.
This study aimed to provide contemporary information on the prevalence , distribution patterns , and etiology of severe VHD in China.
This study aimed to quantify the accuracy and precision ( repeatability ) of free-field human sound localization as a function of advancing age.
This study aimed to report the prevalence and natural history of SS in a population-based study.
This study aimed to validate the NANA toolkit for data collection in the community.
This study aimed to validate the relationship between serum osteocalcin and indices of obesity and lipid parameters in a group of Malaysian men.
This study aimed to validate these comparative differences in a large cohort of individuals and families with HCM.
This study aims assessing the social dependence and frailty , as well as social and familial support needs of the elderly.
This study aims at assessing the feasibility and potential effect of CR in patients with schizophrenia @number@ years of age or older.
This study aims at assessing whether oxLDL modifies the relationship between GGT , all-cause , and CV mortality in elderly individuals from the general population.
This study aims at clarifying body composition changes in healthy elderly subjects , and evaluating the impact of physical activity on these changes.
This study aims to analyse and characterize elder homicide , in order to achieve a better understanding of this form of violence.
This study aims to analyse the associations of smoking habits with LTL and rate of LTL change per year in older adults.
This study aims to assess the incidence and early outcome of hip fractures , comparing between different age groups.
This study aims to assess whether any age-related differences exist in spatiotemporal and stability parameters when walking downhill on three different sloped walkways.
This study aims to assess whether or not a standardized protocol of thermal cycling has been acknowledged from a review of the literature.
This study aims to assist physiotherapists ' clinical reasoning process through the incorporation of accelerometers as part of an electronic data acquisition system.
This study aims to clarify the effects of the EOL care bonus in promoting EOL care in nursing homes.
This study aims to construct an aging score from age-related diseases and to perform longitudinal analyses to examine the association between personal income and aging.
This study aims to contribute to the advancement of knowledge about PCH with the elderly.
This study aims to delineate these relationships using quantitative measures of visceral and subcutaneous fat.
This study aims to describe patients ' and caregivers ' perspectives on conservative treatment and end-of-life care in chronic kidney disease ( CKD ) .
This study aims to describe prevalence and risk factors of AII in a community and a clinic-based population.
This study aims to describe the urban-rural differences in use and cost of long-term care of the disabled elderly and to explore potential influencing factors.
This study aims to determine both independent and combined effect of PIGD and FoF to falls in older adults without dementia.
This study aims to determine dietary lycopene consumption / circulating concentration and any potential dose-response associations with the risk of PCa.
This study aims to determine the fructose concentration and correlate with antioxidant status in senile diabetic and non-diabetic patients with myocardial infarction.
This study aims to determine whether performance on the fast- and usual-paced 400-m walks varies based upon age and physical function.
This study aims to discover new genetic loci associated with heart rate from Exome Chip meta-analyses.Heart rate was measured from either elecrtrocardiograms or pulse recordings.
This study aims to disentangle the relationships of menopausal status and chronological aging with CVD risk factors in the largest study population to date.
This study aims to elucidate the pathogenesis of Work-Mem dysfunction in schizophrenia by comparing metabolite concentrations across ACC subregions.
This study aims to estimate the potential burden of HZ over time accounting for the increasing trends of both HZ incidence and global aging.
This study aims to evaluate how knowledgeable healthcare professionals are about fertility and assisted reproduction , and to explore attitudes towards social oocyte freezing.
This study aims to evaluate its effectiveness regarding smoking prevalence and students ' attitudes towards smoking.
This study aims to evaluate perioral aging process in the male population to compare quality and quantity of the observed changes to the female population.
This study aims to evaluate the association between fall and depressive symptoms in community-dwelling elderly.
This study aims to evaluate the clinical efficacy and safety of this device ( i.e. , ELOS Triniti™ ) .
This study aims to evaluate the effect of multifactorial fall prevention on function , fear of falling , health-related quality of life and psychological well-being.
This study aims to evaluate the impact of synkinesis on UVFP patients.
This study aims to examine factors related to volunteerism and explore the relationship between volunteerism and positive aging across three age groups.
This study aims to examine if the alteration in estrogen level is responsible for the changes of serum PCSK9 concentration.
This study aims to examine the association between childhood abuse and elder abuse reported by Chinese adult children in the United States.
This study aims to examine the association between self-neglect , its phenotypes , and suicidal ideation among U.S. Chinese older adults.
This study aims to examine the association between sources of social support and cancer screening behaviors among Chinese older adults in the greater Chicago area.
This study aims to examine the associations between social support / strain and cognitive outcomes.
This study aims to examine the cross-sectional and longitudinal relationships between TIP and depressive symptoms among Chinese older adults in the Chicago area.
This study aims to examine the effect of SCD on postural stability.
This study aims to examine the level of trust in physicians among Chinese older adults in a community-dwelling Chinese aging population.
This study aims to examine the prevalence of cardiovascular and pulmonary symptoms among U.S. Chinese older adults.
This study aims to examine the sociodemographic factors associated with physical function decline among U.S. Chinese older adults through a longitudinal population-based study.
This study aims to explore cutaneous features of DM1 and DM2 patients.
This study aims to explore the impact of migration on the health of the elderly left behind and their health care-seeking behavior.
This study aims to further clarify which of these factors predict higher activity involvement.
This study aims to identify , explore , and better understand the key challenges for strengthening the Laotian health workforce.
This study aims to identify potentially modifiable social and physical neighborhood characteristics that influence depressive symptoms independent of individual-level characteristics among older Chinese.
This study aims to identify predictors of the evolution of mild parkinsonian signs in non-demented older adults.
This study aims to identify the common risk factors for mortality in community-dwelling older men.
This study aims to improve the prediction on medical services demand in China.
This study aims to investigate characteristic changes after treatment and to identify potential prognostic predictors.
This study aims to investigate the association between filial discrepancy and depressive symptoms.
This study aims to investigate the effects of aging on the rate of muscle activation and rapid force characteristics of the plantar flexors.
This study aims to investigate the village doctors ' aging situation and its implications in rural China.
This study aims to provide a clinically driven comprehensive list of chronic conditions to be included when measuring multimorbidity.
This study aims to quantify the relationship between cerebellar tissue volume and manual motor performance.
This study aims to systematically review the scientific literature to identify measures of mobility limitation for community-dwelling older adults.
This study aims to test whether these changes have reduced work-load as assessed by entheseal changes.
This study also aimed to compare food intake and dietary allowances.
This study also demonstrated that better functional capacity reflects better cognitive performance.
This study also demonstrated the importance of age and family financial exchange to the life satisfaction of urban older adults.
This study also incorporates changes in screening prevalence , sensitivity screening maneuvers and lowering threshold for biopsies.
This study also investigated dermal CD271 + cells in patients with chronic skin ulcers.
This study also performed combined meta-analyses of all the three models to investigate the overall effectiveness of the intervention programmes.
This study also provided a successful construct validation of the DII using CRP in a nationally representative sample.
This study also provides a useful example of how to examine contributions to prescribing variation at different levels of the health care system.
This study also provides further information regarding the relationship between BDNF methylation levels and MCI in Xinjiang Uygur and Han ethnic groups.
This study also provides support for the hypothesis that certain types of reminiscence produce their own specific effects.
This study also suggested that motor control was affected by the frailty syndrome , i.e. a decreased resistance to stressors , which characterises older adults.
This study also took advantage of droplet digital PCR ( ddPCR ) to validate heteroplasmies and confirm a de novo mutation.
This study also used a SAEHAN Digital Hand Dynamometer to measure handgrip muscle strength.
This study analyses the characteristics , effects , contributing factors and policies for urban household carbon emissions in the Yangtze River Delta of China.
This study analyzed the association of age and sex with the risk of in-hospital stroke or death following carotid endarterectomy under routine conditions in Germany.
This study analyzed the household data collected in face-to-face interviews from January to March of @number@ in six major Indian cities.
This study analyzed the possible role of the Inhibitory Deficit Hypothesis in explaining face naming impairments during aging.
This study analyzed the possible role of these approaches in explaining both object and face naming impairments during aging.
This study analyzed the relationship between frailty syndrome ( FS ) and PFF indicators and assessed how the latter might predict the former.
This study analyzes pig smallholders in Xishuangbanna , a prefecture of Yunnan Province.
This study analyzes the influence of a short aging on lees on the chemical and sensorial parameters of this young white wine.
This study analyzes thein vitro and in vivo interaction at the telomere between WRN and DNA-PKcs , the catalytic subunit of DNA-PK.
This study analyzes the relationship by examining the impact of health examination utilization on the utilizations of outpatient care and inpatient care.
This study applied Kano's model and the analytic network process ( ANP ) to improve the basic framework of QFD.
This study assessed and compared the cyclic patterns of hot flashes and activity levels in treated prostate cancer patients.
This study assessed and compared young adults ' explicit and implicit attitudes towards older adult sexuality.
This study assessed caudate volumetric abnormalities across two narrow age clusters within the childhood period.
This study assessed CV and metabolic features of T2DM offspring according to parental lifespan.
This study assessed differences in dynamic FC between young healthy adults ( YH ) and elderly healthy adults ( EH ) compared to static FC.
This study assessed functional balance among older adults at all grades of chronic obstructive pulmonary disease ( COPD ) and explored balance impairment predictors.
This study assessed motor limits of regular tapping , timing error detection , and correction in @number@ participants aged from @number@ to @number@ years.
This study assessed outcomes from ED visits attributed to BZDs and / or nBZRAs , and variations in these associations by age group.
This study assessed the association between sUA and cognitive impairment in @number@ community-dwelling subjects aged ≥55years living in Beijing , China.
This study assessed the effectiveness of @number@ exercises purportedly reducing wrinkles and sagging of the facial skin.
This study assessed the effect of chronic , supervised exercise on sleep using laboratory-based polysomnography ( PSG ) and repeated measures in older adults.
This study assessed the effects of ageing on cardiorespiratory and tissue oxygenation responses to hypoxia both at rest and during incremental maximal exercise.
This study assessed the epidemiology of IA and azole-resistant Aspergillus spp. in patients with acute leukaemia in Germany.
This study assessed the impact of rotavirus diarrhea on HRQoL of children and their caregivers.
This study assessed the improvement in relationship quality , effectiveness and safety associated with vardenafil for the treatment of erectile dysfunction ( ED ) .
This study assessed the manometric diagnoses of elderly patients with dysphagia compared with diagnoses in younger counterparts.
This study assessed the relationship between intake of nutrients and dental caries in preschool children.
This study assessed this relationship among @number@ patients with schizophrenia @number@ years and older.
This study assesses social engagement patterns among U.S. Chinese older adults.
This study assesses the conformity of prescriptions in elderly patients prior and after the distribution of the booklet.
This study assesses the effect of passive and active smoking on pregnancy rates after IVF with transfer of high-quality embryos.
This study assesses the efficacy and safety of LPND applying new parameters for skin rejuvenation in Korean subjects.
This study assesses the factors influencing the movement of people across health plans.
This study assesses the reproducibility of quantitative susceptibility mapping across different imaging sites.
This study assesses whether the disc space height adjacent to a fused segment is associated with candidate gene single nucleotide polymorphisms ( SNPs ) .
This study attempted to evaluate dental myths , oral hygiene methods and beliefs , and tobacco habits present in a rural ageing population.
This study attempts to ascertain barriers to teaching so appropriate strategies can be formulated to address this issue.
This study attempts to characterize the relationship between age and facial nerve axonal load.
This study bridges gerontology and celebrity studies to explore a social role that celebrities can fulfill for nursing home residents : triggering moral discussions.
This study bridges gerontology and celebrity studies to explore a social role that celebrities can fulfill for nursing home residents : triggering moral discussions.
This study broadens our understanding of specific mechanisms and targets whereby resveratrol provides neuroprotection.
This study can inform physical activity and sedentary behavior interventions for care homes ' residents.
This study can provide useful data for clinicians and health care professionals using sitagliptin monotherapy in the treatment of elderly patients with T2DM.
This study can support policy makers and clinicians to navigate through a large number of QIs and select QIs for their purposes.
This study challenges the current view that pericytes can differentiate into other cells and reopen questions about their plasticity.
This study characterised the astrocyte response to Aβ plaque subtypes , and investigated their association with cognitive impairment.
This study characterises the study of endothelial dysfunction by new cell circulating markers.
This study characterized age trajectories for six aspects of experiences with intrusive thoughts using Internet data collection.
This study characterizes a novel method of early OA detection in a mouse model of post-traumatic osteoarthritis ( PTOA ) using fluorescent nanosomes.
This study clearly demonstrated that there is a significant association between LOH and the higher expression of EPCs and EMPs in patients with vasculogenic ED.
This study clearly demonstrates that oxidative stress damage occurs in patients with MCI and AD.
This study clearly points out identifiable electroclinical differences between adult and pediatric GTCSs that may be relevant in explaining lower SUDEP risk in children.
This study collated data of clinical trials that evaluated tau-based drugs to help development of agent for dementia drugs in future.
This study collected data from @number@ registers concerning health care , drugs , and municipal services and from @number@ surveys.
This study compared demographic characteristics and prevalence of cardiovascular comorbidities between men with mild erectile dysfunction ( ED ) and men with more severe ED.
This study compared , for the first time in Italy , a sample of people with probable Alzheimer's Disease ( AD ) with healthy counterparts.
This study compared overhead and first-person view perspective taking abilities in patients with mild cognitive impairment ( MCI ) and AD.
This study compared the effects of age on the perception of translational , radial , and rotational global motion patterns.
This study compared the effects of aging and dual tasking on step adjustments in response to stepping-target perturbations during visually cued treadmill walking.
This study compared the effects of different weekly training frequencies on the cardiovascular and neuromuscular adaptations induced by concurrent training in previously trained elderly.
This study compared the effects of self-efficacy , self-affirmation and a combination of these techniques for two risk messages.
This study compared the effects of spontaneous speech and executive function on gait and investigated the effects of single-task gait speed on dual-task costs.
This study compared the reliability and validity of different protocols evaluating the force-velocity ( F-V ) relationship and muscle power in older adults.
This study compared young people and older adults with depression to identify differences in suicidality between these groups.
This study compares assessments of psychotic symptoms in persons with dementia , specifically of hallucinations and delusions , through the @number@ most frequently used assessments.
This study compares formal and informal caregivers ' perceptions of delusions and hallucinations in older persons with dementia ( PWDs ) .
This study compares oxidative stress responses between progeric and normal fibroblasts.
This study compares the functional outcomes after surgery for DRF in patients with or without low appendicular lean mass plus slowness or weakness.
This study compares the outcomes of operative and nonoperative management.
This study compares the thymic output and peripheral blood telomere length in ≥70year old cancer patients.
This study concludes that mainstream elder-service provider training on LGBT aging issues results in positive change.
This study conducted detailed field surveys to identify specific factors of and potential solutions to the shortage in village doctors.
This study confirmed previously reported associations for rs3801387 and rs2707466 with bone mineral density ( BMD ) at several sites.
This study confirms an association between NCC and hippocampal atrophy , and shows that this association is stronger in older age groups.
This study confirms results found in quantitative studies and uncovers new processes that promote emotion regulation.
This study confirms that as the brain ages , there is softening ; however , the changes are dependent on region.
This study confirms that the obesity epidemic also extends into late life in the current elderly population.
This study confirms that the validity and reliability of OLQ- @date@ differ substantially in different populations.
This study confirms the anti-inflammatory activity of resveratrol and its derivatives and suggests a potential clinical relevance in the therapy of inflammatory diseases.
This study confirms the rationale for injecting fat at the time of face-lift surgery.
This study connects two emerging longevity metabolites , β-hydroxybutyrate and NAD ( + ) , through the deacetylase SIRT1 and suggests possible interventions for CS.
This study consisted of @number@ surveys ( 1972-2002 ) on representative samples of the general population in Finland ( National FINRISK Study ) .
This study constructs a system architecture to develop an e-screening system for child developmental delays.
This study contributes to the development of evidence-based practice regarding malnutrition and persons with dementia.
This study contributes to the limited literature on lay longevity reckonings , with a particular focus on how these reckonings may influence health behaviours.
This study contributes to this line of inquiry by examining a variety of physical and mental health indicators among an older cohort of prisoners.
This study deepens existing knowledge by demonstrating how chronic illness and sexual minority status can further exacerbate the consequences of rationing public care.
This study demonstrated that DTD could significantly inhibit the expression of ICAM-1 , p53 and p21 , which are important factors of atherosclerosis.
This study demonstrated that overexpression of Casp12 mediated IκBα degradation and significantly increased NF-κB activity.
This study demonstrated that the age-related decrease of leftward bias may actually be sex-specific.
This study demonstrated that this proprietary T. foenum-graecum de-husked seed extract may reduce menopausal symptoms in healthy women.
This study demonstrated the effects of age and gender on lordosis , sacrum orientation and lumbopelvic rhythm.
This study demonstrates a comparative assessment of the causes of nocturia in young and elderly patients with overactive bladder ( OAB ) .
This study demonstrates a relationship of low vitamin D levels with increased cellular aging in females.
This study demonstrates feasibility and utility of neurocognitive testing in Spanish using TP among older rural Latinos.
This study demonstrates , for the first time , preserved complex emotion-based learning capacity , despite profound episodic memory impairment in Alzheimer's disease.
This study demonstrates that heat , expressed as humidex , is associated with increased hospital admissions.
This study demonstrates that long-term tactile training might prevent the known age-dependent decline of the sensibility of the hand.
This study demonstrates that persons with COPD exhibit worse Rhythm , especially fallers with COPD.
This study demonstrates that the 1410-nm fractional erbium fiber laser is effective and safe for treatment of dilated facial pores in Fitzpatrick skin types III-IV.
This study demonstrates the effects of Quinton's isotonic and hypertonic solution on mononuclear cells of peripheral blood.
This study demonstrates the feasibility of measuring facial EMG response to emotional facial expressions in 6-7year old children.
This study demonstrates the potential of polyphenols for protecting both the viability of cells and their ability to proliferate from damage caused by UV-A-irradiation.
This study demonstrates the safety and efficacy of combining RF and optical energies for the esthetic improvement of aging hands.
This study depicts various characteristic patterns of dermatoses seen in elderly.
This study describes a 2-year effort to promote coverage of health through dissemination of localized health news releases to newspapers.
This study describes an evaluation of a partnership approach to learning involving nursing students and older adults.
This study describes attitudes to ageing among @number@ Norwegian older adults living in the community who responded to The Attitudes to Ageing Questionnaire.
This study describes how Canadian newspapers represent workers with hearing loss.
This study describes lesbian , gay and bisexual people's accommodation plans for old age through a cross-sectional quantitative survey design.
This study describes the changes in cortical bone during ageing in healthy males.
This study describes the clinical characteristics of patients with LOMS followed at a specialized MS center in São Paulo.
This study describes the development of and provides preliminary evidence for the multidimensional Social Integration in Later Life Scale ( SILLS ) .
This study describes the development phase of the individual cognitive stimulation therapy ( iCST ) for dementia trial , within this framework.
This study describes the impact this transition had on PLT availability and safety in Namibia.
This study describes the mental health experiences of older adults living with HIV in Ottawa.
This study describes the most recent updates for the @number@ round of estimates.
This study describes the prevalence , size and topographical distribution of MDx in the human otic capsule.
This study describes the unique supportive care needs and associated distress among older adults receiving cancer survivorship care in a community cancer center.
This study details the capacity of nanosecond laser treatment to reduce drusen and thin BM while maintaining retinal structure.
This study determined limits to describe the effect of light level on normal , age-related changes in monocular and binocular functional contrast sensitivity.
This study determined longitudinal patterns of medical student interest in a surgical career and factors influencing that choice.
This study determined the long-term outcome for patients after myocardial infarction ( MI ) due to Kawasaki disease ( KD ) .
This study determined whether there is a relationship between endothelial function and relative telomere length ( RTL ) in MetS subjects.
This study determines patterns of multimorbidity associated with emergency-room visits and hospitalization in an 85-year-old population.
This study determines the validity and reliability of the Wii Balance Board ( Wii BB ) to quantify CoP motions during the mentioned tests.
This study develops an approach to this question , which is necessary for aMCI to become a treatment target.
This study distinguishes between Aβ-specific and nonspecific mechanisms and provides potential targets for therapeutics discovery.
This study does not support BIA as an accurate method for the individual assessment of body composition.
This study draws upon patients ' descriptions of their pain , to identify and understand their perception of osteoarthritis pain and to categorize pain dimensions.
This study elucidated whether components of SC are linked to the psychogeriatric health of older Japanese individuals.
This study elucidates how various exercises regimens with / without hypoxia affect phenotypic characteristics of T-lymphocyte subsets in blood.
This study , embedded in the prospective Rotterdam Study , included all successfully genotyped participants with data on depressive symptoms ( CES-D scores ) .
This study emphasized the importance of taking into account multimorbidity between asthma and rhinitis and showed that allergic sensitization is not a dichotomic variable.
This study employed an individual-based computer simulation , to emulate mosquito control and vaccination , incorporating seroconversion rates reported from actual clinical trials.
This study enrolled @number@ ESRD patients receiving chronic hemodialysis who were categorized into low- and high-FGF21 groups by the median value.
This study enrolled @number@ small left-to-right shunt patients with normal aortic circulation below @number@ years of age.
This study especially showed that elderly patients are affected by the return of bowel movement after totally laparoscopic gastrectomy.
This study establishes a role for Δ133p53 and p53β in regulation of cellular proliferation and senescence in vivo.
This study establishes the relationship of PEFR with age and BMI in healthy adult males ( N = 300 ) of Kumaon region of Uttarakhand.
This study evaluated an online tool to assist in this decision process.
This study evaluated a training program to assist staff to manage BPSD in residential care.
This study evaluated bond strength of non-aged and aged resin composite to an indirect resin composite and pressed glass ceramic using two resin cements.
This study evaluated linear and nonlinear gait features in healthy older adults walking on inclined surfaces at different speeds.
This study evaluated relationships between fatigue and both sympathetic and parasympathetic nervous system activity in breast cancer survivors.
This study evaluated reported changes in practice behaviors @number@ months posttraining in @number@ professionals trained via the AMA approach.
This study evaluated the absorption of silicon from bottled artesian aquifer water and its effect on markers of bone metabolism.
This study evaluated the anatomical foundation for tear trough and palpebromalar groove.
This study evaluated the associations between executive function and physical performance in a representative sample of older adults.
This study evaluated the clinical efficacy of laninamivir octanoate for the treatment of adult influenza patients.
This study evaluated the colour stability of temporary prosthetic restorations with different thicknesses submitted to artificial accelerated aging.
This study evaluated the differential changes in the nasal and central fat pads of the upper eyelid associated with aging.
This study evaluated the effectiveness of a telephone-delivered psychoeducational intervention for family caregivers of PWD in alleviating caregiver burden and enhancing caregiving self-efficacy.
This study evaluated the effectiveness of common bathroom aids in promoting balance control during bathing transfers.
This study evaluated the effect of IDS on the fracture strength and failure types of two indirect restorative materials.
This study evaluated the effect of PEHPCP on physical fitness and on the aging process after a decade of ongoing implementation.
This study evaluated the effects of @number@ mg and @number@ mg of caffeine on sleep in young and middle-aged adults.
This study evaluated the feasibility of plate waste collection in QSRs and examined children's orders and consumption of meals from the standard and children's menus.
This study evaluated the feasibility of using a computer-based assessment battery , including simulations of everyday activities.
This study evaluated the impacts of ageing on physical standards of Australian firefighters.
This study evaluated the in-depth daily experiences of older widows compared to married women.
This study evaluated the performance of two pipelines : Civet-CLASP ( @date@ @number@ ) and Freesurfer ( @date@ @number@ ) .
This study evaluated the prothrombotic properties of senescent endothelial cells ( ECs ) and the underlying mechanism.
This study evaluated the role of TREM2 in LOAD risk in African-American ( AA ) subjects.
This study evaluated the viscoelastic properties of the SMAS within the biomechanical parameters of the high-SMAS rhytidectomy.
This study evaluated validity and reliability of the seated medicine ball throw ( SMBT ) in older adults.
This study evaluated whether obesity and poor muscle strength are associated with venous thromboembolism ( VTE ) .
This study evaluated whether physical activity ( PA ) , computerized cognitive training and / or a combination of both could improve cognition.
This study evaluated which baseline demographic , neuropsychological , and functional variables were most strongly associated with future longitudinal decline in global cognitive function.
This study evaluates health status among elderly residents in urban China and medical insurance schemes for them.
This study evaluates rates of diagnosis of each proposed criteria set in a clinical sample of bereaved individuals participating in clinical research.
This study evaluates the ability of this technology to preserve DNA samples mimicking true mixture casework samples for long periods of time.
This study evaluates the association between a cytosine-adenine ( CA ) microsatellite polymorphism in the IGF1 gene promoter P1 and age at natural menopause.
This study evaluates the effects of pre-rigor temperature control on quality traits of Chinese yellow cattle M. longissimus lumborum ( LL ) .
This study evaluates the impact of Brain Gym ( BG ) training in active older adults.
This study evaluates the impact of demographic and smoking-related participant characteristics on compliance to an EMA smoking study protocol.
This study evaluates the prevalence of UI and the impact on HRQOL among older cancer survivors.
This study evaluates the short-term effects , as compared to regular activities offered in the milieu.
This study evaluates the simultaneous impact of these conditions on physical performance in older adults.
This study evaluates whether previous depression and recent depressive symptoms are associated with HcV and HcV loss.
This study examined adult age differences in reflexive orienting to two types of uninformative spatial cues : central arrows and peripheral onsets.
This study examined affect and well-being similarity between @number@ older married couples in India using pilot data from the Longitudinal Aging Study of India.
This study examined age differences in postural stability during a forward reach under two task contexts , grasping versus pointing to a target.
This study examined age differences on the sense of authenticity and its relation with mental health measured on the General Health Questionnaire.
This study examined age-related alterations in electrocortical indices of performance monitoring in a probabilistic learning situation.
This study examined age-related and socio-cultural context effects on cognitive failures while controlling for depressive symptoms.
This study examined age-related differences in the ability to judge one's vocabulary.
This study examined age-related differences while tracing on high- and low-friction touchscreens using the finger or stylus.
This study examined a population-based profile of older adults with acquired brain injury , and their functional outcomes , in in-patient rehabilitation.
This study examined articles discussing associations between physical activity and cognitive health in top-circulating magazines targeting older adults.
This study examined associations between elder abuse and dimensions of depressive symptoms in older adults.
This study examined associations between hair cortisol concentrations , a novel indicator of long-term cortisol exposure , and adiposity in a large population-based sample.
This study examined associations between mental disorders and alcohol use / nonuse patterns among individuals aged 65 + years.
This study examined brain activation during DTW among older adults with mild cognitive impairment using functional near-infrared spectroscopy.
This study examined certified nursing assistants ' ( CNAs ) experiences of nursing home practices following resident death.
This study examined changes in phospholipid composition in the mitochondrial and microsomal membranes of human dorsolateral prefrontal cortex over the adult life span.
This study examined competing substantive hypotheses about dynamic ( i.e. , time-ordered ) links between memory and functional limitations in old age.
This study examined correlates of susceptibility to scams in @number@ community-dwelling older adults without dementia from a cohort study of aging.
This study examined differences in psychosocial experiences and reincarceration between older and younger adults with psychiatric disorders involved in the criminal justice system.
This study examined differences in the frequency of leisure activity participation and relationships to depressive symptom burden and cognition in Latino and Caucasian women.
This study examined DNA methylation of CpG islands upstream of OGG1 and their relation to the gene expression in lens cortex from ARC patients.
This study examined domain-specific effects of common neuropathologies on cognition using data ( N = @number@ ) from two large cohort studies of older adults.
This study examined dyadic interrelations between episodic memory and depressive symptom trajectories of change in old and advanced old age.
This study examined elderly trauma patients to determine whether there was a difference in neutrophil response to injury when compared with controls.
This study examined expected QoL in a random sample of the population of Dalarna , a Swedish region.
This study examined for which aspects of motor sequencing performance these relationships hold.
This study examined health disparities and the potential intervention role of social engagement in eliminating health disparities.
This study examined hospitalized older adults ' perceptions regarding three groups of treatment providers : nursing staff , family members , migrant home care workers.
This study examined how caregiver internal resources changed over a @number@ year period , and how this was related to caregivers ' well-being.
This study examined how nursing home facility ownership and organizational characteristics relate to emergency department ( ED ) transfer rates.
This study examined how patients experience transitions to community from hospitals , inclusive of daily living problems and medical concerns.
This study examined how thinking about events in different ways after their occurrence can influence younger and older adults ' memory for what really occurred.
This study examined how two domains of engagement-social network and activity participation-associate with objective and subjective cognitive function in later life.
This study examined if leg muscle strength correlates to functional balance and mobility among geriatric inpatients.
This study examined if the rules known from such tasks can be generalized to activities of daily living.
This study examined individual , social , and physical environmental correlates of older adults ' television viewing.
This study examined isometric tongue strength and tongue pressure measured during swallowing in healthy young and older adults.
This study examined location-specific effects within anatomically-defined white matter tracts in @number@ participants of the Rotterdam Study , aged 50-95.
This study examined longitudinal relations of habitual coffee use to resting BP and pulse pressure.
This study examined mRNA expression patterns for atrogin-1 and muscle ring finger-1 ( MuRF-1 ) before and @number@ hours after a resistance training bout.
This study examined neural correlates of empathy in adolescence while observing harmful acts.
This study examined potential issues faced by older adults in managing their homes and their proposed solutions for overcoming hypothetical difficulties.
This study examined prospective relationships between religious factors and hippocampal volume change using high-resolution MRI data of a sample of @number@ older adults.
This study examined relationships between different mobility measures and EFs among rural older adults.
This study examined sex differences in the association of urinary level of bisphenol-A ( BPA ) with selected indices of glucose homeostasis among U.S. adults.
This study examined social factors as predictors of using smoking cessation treatment among adults with serious mental illness.
This study examined stroke risk associated with patterns identified by both approaches.
This study examined support that young adults provide parents and explanations for that support from both offspring's and parents ' perspectives.
This study examined the accuracy of informant-reported mood disorder diagnoses in a sample of primary care patients aged @number@ years or older.
This study examined the age-related subsequent memory effect ( SME ) in perceptual and semantic encoding using event-related potentials ( ERPs ) .
This study examined the association between baseline and changes in physical activity and cognitive decline in community-dwelling older people.
This study examined the association between driving mobility and trajectories of cognitive functioning among older adults.
This study examined the association between episodic heavy drinking and total mortality among moderate-drinking older adults.
This study examined the association between inflammation and both T2DM and elevated depressive symptoms.
This study examined the association between SES and depressive symptoms in older adults.
This study examined the association between size of the caudate nuclei and intelligence.
This study examined the association of lung function with multiple measures of functioning in early old age.
This study examined the association of muscle mass in older people with retinal vascular width , a non-invasive measure of vascular function.
This study examined the associations between LTL and the immune system , axis and autonomic nervous system.
This study examined the cognitive and neurohistological effects of TBI in presymptomatic APP / PS1 AD-transgenic mice.
This study examined the concept of bridge employment from a continuity theory and life course perspective.
This study examined the concept of successful aging using an ethnographic grounded-theory approach.
This study examined the cortisol secretion pattern and declarative memory performance of dementia caregivers.
This study examined the demographics and health characteristics of depressive symptoms of Korean older adults.
This study examined the development of source memory in middle childhood.
This study examined the effect of cationic liposomes on human neutrophil activation.
This study examined the effect of menstrual cycle phase in the association between subjective stress and physiological response.
This study examined the effects of age and hearing loss on short-term adaptation to accented speech.
This study examined the effects of a multimodal intervention on spontaneous brain activity in healthy older adults.
This study examined the effects of grandchild care on the cognitive functioning of Korean grandmothers and the moderating role of education.
This study examined the effects of localized muscle fatigue , age , and gender on lower extremity joint torques used during quiet stance.
This study examined the effects of passive leg cycling on executive function in PD.
This study examined the effects of physical activity on working memory in older adults using both behavioral and neuroelectric measures.
This study examined the efficacy of motivational interviewing ( MI ) for increasing physical activity in aging adults.
This study examined the frequency and predictors of sedative-hypnotic medication use among older adults screening positive for anxiety.
This study examined the GWIR and its influence on cortical thickness in normal aging , mild cognitive impairment ( MCI ) , and AD.
This study examined the impact of visually guided weight-shifting training on elderly women's limits of stability during static leaning and dynamic swaying in different directions.
This study examined the impacts of age and obstacles on reaction time ( RT ) and navigation precision during blind navigation in dual-task conditions.
This study examined the incidence , magnitude , and timing of these components and how they change across the lifespan ( ages 20-79 ) .
This study examined the intensity of activity contributing to physical activity energy expenditure in older adults.
This study examined the level of willingness to evacuate among older adults in the event of a disaster.
This study examined the moderating role of an IQ estimate on the beneficial effects of strategy instructions.
This study examined the performance of six aging techniques on a known age sample of @number@ Southeast Asian individuals.
This study examined the potential linkage between personal coping resources and family and marital conflict among U.S. Chinese older adults.
This study examined the prevalence , types , and perceived impact of intergenerational programs in schools.
This study examined the process of change in parental behaviors during their son's transition.
This study examined the relation between Five Factor Model personality traits and objective physical activity in older adults.
This study examined the relations between social support and executive functioning in middle-aged adults.
This study examined the relationship between race and advance care planning , hospitalization , and death among nursing home residents receiving hospice care.
This study examined the risk of cognitive impairment associated with dietary patterns identified by both approaches.
This study examined the role of executive capacity ( EC ) and aging in multidimensional feature selection.
This study examined the role of frailty in explaining the association between MetS and mortality , independent of comorbidity.
This study examined the role of mTOR signaling in uterine aging and its implications in the development of endometrial hyperplasia.
This study examined the role of sexual minority identity as a factor that is associated with health information technology use.
This study examined the semiological and electroencephalographic differences ( EEG ) in the GTCSs of adults as compared with those of children.
This study examined the validity of facial expression components of @number@ widely used pain assessment scales developed for elders with dementia.
This study examined the ways in which individuals over @number@ years old solved problems while volunteering in intensive humanitarian and disaster relief service.
This study examined the weight transfer ability of elderly individuals during unconstrained standing ( for @number@ min ) in comparison to young adults.
This study examined the within-person relationship between sleep and cognitive functioning.
This study examined whether age-related differences in cognition influence later memory for irrelevant , or distracting , information.
This study examined whether baseline and change in vision and hearing were associated with personality change over a 4-year period.
This study examined whether beliefs about face recognition ability differentially influence memory retrieval in older compared to young adults.
This study examined whether geriatric syndromes and their cumulative effects are associated with risks of mortality in community-dwelling older adults.
This study examined whether higher midlife CRF was prospectively associated with slower atrophy , which in turn was associated with higher late-life CRF.
This study examined whether inflammatory potential of diet , as measured by the Dietary Inflammatory Index METHODS AND RESULTS : Data came from NHANES 1999-2002.
This study examined whether motivational incentives modulate age-related perceptual deficits.
This study examined whether satisfaction with and enjoyment of volunteering indirectly affect volunteer cessation via hours volunteered.
This study examined whether sleep problems are associated with subsequent disability retirement.
This study examined whether social support moderated the relationship of depressive symptoms to walking behavior among @number@ community-dwelling , Hispanic older adults.
This study examined whether stereotype-inconsistent information interacts with implicit theories of ability to affect handgrip strength in older adults.
This study examined whether such forgetting occurred for associatively structured lists and if aging influenced such forgetting.
This study examined whether the associations were moderated by driving status.
This study examined whether variation over @number@ days in everyday SOC was associated with happiness in a sample of @number@ adults ages 22-94.
This study examines age-related differences in inhibitory control as measured by stop-signal performance.
This study examines a link between TXS expression , angiogenesis , and survival in NSCLC.
This study examines and further develops the classic Strehler-Mildvan ( SM ) general theory of mortality and aging.
This study examines central auditory language processing with a dichotic listening task in right-handed old subjects according to their age.
This study examines diagnostic and service utilization patterns of transition-age youth in outpatient care derived from the @number@ nationally representative Client / Patient Sample Survey.
This study examines elderly residential life in long-term care settings , focusing on the ways residents interact with their physical and social environments.
This study examines electroglottographic ( EGG ) recordings for @number@ young and @number@ old male speakers of New Zealand English.
This study examines facial tissue depth in Canadian Mi'kmaq adults.
This study examines folate and related thiol metabolism that might underpin either phenomenon.
This study examines how emotion-focused orientation at retrieval affects memory for emotional versus neutral images in young and older adults.
This study examines how English colonists and Indians viewed and treated older Native American adults in part of northeastern North America.
This study examines if a 2-hour didactic intervention can significantly improve resident knowledge in @number@ key domains as identified by the GEMC across multiple programs.
This study examines longitudinal changes in symptom remission rates and predictors of remission.
This study examines long-term mortality in community-dwelling elderly subjects affected by CHF alone , COPD alone , and coexistent CHF and COPD.
This study examines mortality with external causes excluded.
This study examines negative mood and depressive occurrence in the menopausal stages to provide a better understanding of prevalence of mood disturbance during this period.
This study examines patterns of incarceration among Vietnam veterans treated in specialized veterans affairs ( VA ) intensive PTSD programs over time.
This study examines possible associations between cognitive impairment and exercise , cognitive activities , and socialization.
This study examines the association between serum ALT and age in a community-dwelling cohort in the United States.
This study examines the association of sexual identity and gender among older clients with HIV at an AIDS service organization using the Andersen Model.
This study examines the association of work and health-related characteristics with the intention to continue working after the age of @number@ years.
This study examines the changes in activity investment among older adults and the role of these changes in the relationship between health limitations and depression.
This study examines the characteristics and contributing circumstances of nonfatal older adult pedestrian injuries.
This study examines the characteristics of hardcore smokers in South Korea.
This study examines the characteristics of neighborhood environments associated with fall injuries reported to EMS providers.
This study examines the complex role of family networks in shaping adult psychological well-being over time.
This study examines the effectiveness of a prevention program to increase older adults ' knowledge about these risks.
This study examines the effect on PVF performance of a brief crossword-based intervention in a cognitively normal , community-based sample.
This study examines the effects of developing motor control on the speed and accuracy of visual search.
This study examines the effects of sleep deprivation on toll-like receptor activation of monocytic inflammation in younger compared to older adults.
This study examines the influences of physical and mental function on co-resident relationships in AL and identifies the factors shaping the influence of functional status.
This study examines the knowledge of nursing home staff about the types and treatment of urinary incontinence as well as attitudes toward urinary incontinence.
This study examines the perceptions and treatment of older Native American adults in colonial New England ( 1620-1783 ) .
This study examines the perspectives of aging cancer patients on the financial burden of their cancer treatments.
This study examines the possible transfer effects of step training on stepping performance in untrained directions in older people.
This study examines the predominance of the residential context within older adults ' everyday lives.
This study examines the quality of life of the elderly residents of two rural Nebraska towns , both having experienced a large increase in population.
This study examines the quality of life of the elderly residents of two rural Nebraska towns , both having experienced a large increase in population.
This study examines the relationship between systemic inflammation and MCI subtypes.
This study examines the relationships among depressive symptoms , transitions to widowhood , worsening health , and family support in Japan over @number@ years.
This study examines these associations longitudinally.
This study examines the socioeconomic and psychosocial predictors of FBCP among older African American men ( AAM ) .
This study examines the way mental health need affects the number of physician contacts by older Asian Americans.
This study examines use and effects of pharmacologic treatment for persistent pain in older adults.
This study examines whether differences in late-life well-being are linked to how older adults encode emotionally valenced information.
This study examines whether economic recessions experienced in early and mid-adulthood are associated with later-life cognitive function.
This study examines whether midlife change in episodic memory predicts hippocampal volume in old age.
This study examines whether milestone birthdays change the way people evaluate their life.
This study examines whether social support and self-efficacy moderate the associations between physical health and depression and anxiety.
This study examines whether specific types of neighborhood characteristics moderate that association.
This study examines whether the association between elevated BP and AMI risk differs by HIV status.
This study examines whether the diction and phrasing of consultation recommendations in the electronic health record influence their implementation.
This study examines whether working conditions at the end of workers ' careers impact health and contribute to health disparities across occupations.
This study exhibited a direct inhibition interaction between AR and iNOS in HLECs.
This study expands previous evidence of generalized cognitive gains after mental training in healthy seniors.
This study expands the current scholarship on the relationship between environment and aging as well as our understanding of poverty among older persons.
This study experimentally examined the affective and social consequences of emotion regulation in men and women from young adulthood to old age.
This study explored age- and sex-related differences in orofacial strength.
This study explored and examined the relationship between SES and BMD by race / ethnicity and gender.
This study explored associations between glucose dysregulation and markers of immunosenescence in CMV ( + ) and CMV ( - ) individuals.
This study explored beliefs about the shape and continuity of healthy adult sleep at different adult ages.
This study explored different domains of these activities and their moderating roles on the relationship between education and cognition.
This study explored effects of the metabolic syndrome ( MetS ) on language in aging.
This study explored experiences of South Asian Canadians , Canada's largest visible minority group , prior to dementia diagnosis.
This study explored factors associated with extent of EA victim service utilization ( SU ) .
This study explored factors contributing to older adults ' self-perceptions about their own aging in assisted living ( AL ) communities.
This study explored how culture shapes relationships in aged care and the extent to which the residential aged care sector supports a cohesive multicultural workforce.
This study explored how self-esteem is related to variables that can influence high-risk sexual behaviors in women over @number@
This study explored how the work environment influences registered nurses ' ( RNs' ) perceived quality of geriatric care in rural hospitals.
This study explored person-centred , multidimensional , empirically-derived profiles of psychosocial functioning in the elderly and related each trajectory to differing configurations of SWB.
This study explored the costs of dual-tasking in relation to SH severity in AD and normal controls ( NCs ) .
This study explored the dementia journey through the viewpoints of health service providers , caregivers , community members , and people living with dementia.
This study explored the differential impacts of stressors and coping resources on the functioning and roles of @number@ older Korean immigrant men and women.
This study explored the life experiences of this group using a qualitative approach.
This study explored the mediating effects of psychosocial factors on trajectories of concerns about falling and daily activity in a multicomponent cognitive behavioral group intervention.
This study explored the nature of empathy and its association with attitudes about , and exposure to older patients in a sample of dental students.
This study explored the role of HCC in predicting job well-being and moderating the impact of perceived stress on job well-being.
This study explored the sexual subjectivities of older Australian women.
This study explored the social care networks of this population using a mixed-methods approach.
This study explored the social interaction processes of knowledge translation ( KT ) related to how UI management knowledge might be translated within in-home care.
This study explored whether greater objectively measured daily walking activity was associated with larger hippocampal volume.
This study explored whether physical activity and sleep , combined with the biomarker C-reactive protein , indexed positive health in older men.
This study explored whether there is a relationship between food insecurity and PAD among a national sample of older adults.
This study explored why people do or do not engage in activities following hip or knee TJR.
This study explores an unexpected interaction between APC-2 and SCFFBG1.
This study explores how and why abuse and neglect occurs in geriatric institutions and presents practical prevention measures.
This study explores how moral reasoning is expressed in matching health care with the problems older persons experience in their everyday life.
This study explores how well morbidity and mortality in postal survey respondents aged @number@ years and older represented that of the target population.
This study explores older incarcerated women's perceptions of prison health care policies and their day-to-day survival experiences.
This study explores rural elderly preferences for support across a multi-dimensional measure of elderly care needs.
This study explores state-level diversity initiatives to welcome these social minorities in CMPs.
This study explores the concept of meaningful activity , as defined by caregivers of PWDs.
This study explores the dynamic relationship between participation in social activities and trajectories of depressive symptomatology among older Taiwanese adults surveyed over @number@ years.
This study explores the educational disparities in a wide range of health outcomes among the oldest old in Sweden between @number@ and @number@
This study explores the effects and possible mechanisms of NLRP3 inflammasome in endothelial cells senescence.
This study explores the effects of early-life and middle-life conditions on exceptional longevity using two matched case-control studies.
This study explores the experience of francophone persons with dementia ( PWD ) and their caregivers during the peri-diagnostic period.
This study explores the experiences and challenges that Asian H1B workers face when providing care from a distance.
This study explores the financial and social implications of continuing to charge premiums to people aged @number@ to @number@ years.
This study explores the potential of scalp EEG for early detection of alterations from cognitively normal status of older adults signifying MCI and AD.
This study explores the UFH-dependent tissue factor pathway inhibitor ( TFPI ) release in children compared to previously published data in adults.
This study explores whether the association between leisure involvement and well-being in later life changes over time.
This study extends our understanding of the role of frontal executive beyond purely cognitive tasks to cognitive-motor tasks.
This study extends prior work to include all PLWH and examines associations between AIDS , CD4 count , and age at cancer diagnosis.
This study extends this literature by identifying specific executive function deficits underlying past and future thinking in AD.
This study firstly reported the association between tooth loss and cognitive function among Chinese older population.
This study focused on the period from the first signs of cognitive difficulties to the diagnosis of dementia.
This study focused on the relationship between dietary patterns and prevalence of the sarcopenia in menopausal women.
This study focuses on the consequences of small-scale care on staff's perceived job characteristics.
This study focuses on the development of a mathematical model to quantify the effect on human dengue cases of introducing Wolbachia into the mosquito population.
This study focuses on the latter , analyzing the way patients aged 65-85 cope with multimorbidity.
This study focuses on type @number@ diabetes mellitus , especially on undiagnosed cases and their increased risk of cognitive impairment.
This study followed current and former workers ( n = 1396 ) for up to @number@ years and collected @number@ pulmonary function tests.
This study found a small but significantly increased risk of hospitalization for stroke immediately following the initiation of typical antipsychotics.
This study found buccinator muscle fibers invading the parotid duct wall near its opening in 6-month-old fetuses and older.
This study found higher ox-LDL concentrations were associated with MS and its components independently of central obesity and insulin resistance.
This study found that @percent@ of the NT Salmonella-related hospitalization and @percent@ of the deaths recorded in the Canadian adult population occurred in seniors.
This study found that these dental and dental hygiene students had different opinions regarding the scope of practice for dentistry and dental hygiene.
This study further indicated that lifespan extension and enhanced stress resistance induced by piceatannol requires DAF-16.
This study furthers our understanding of some important determinants influencing Japanese HRQOL , using the EQ-5D in Takamatsu , Japan.
This study goes beyond cross-sectional analyses by examining the predictors of NH residents ' QOL on the facility level over time.
This study has also identified areas for mental health nurses to target interventions.
( This study has been registered at ClinicalTrials.gov under registration no.
( This study has been registered in the United States at ClinicalTrials.gov under registration no.
This study has brought the potential use of antiepileptic drugs ( AEDs ) in AD therapy.
This study has implications for healthcare professionals , social services agencies and policy makers.
This study has implications for models of care underpinning old age psychiatry.
This study has important implications for retirement policies for women.
This study has validated the potential use of VRF as an anti-oxidant to fight age-related problems.
This study highlights age-related differences in physical abilities and the risk for the loss of independence in later life.
This study highlights an effective approach to engineering elastic functional vascular smooth muscle tissue for tissue engineering and regenerative medicine applications.
This study highlights an important motivational construct , WTL , which regulates life satisfaction when death approaches.
This study highlights a previously unidentified mechanism by which aging impairs Mϕ phagocytosis of bacteria.
This study highlights evidence on the degree of DVT risk , risk factors , and impact of venous thromboembolism in patients undergoing major orthopedic operations.
This study highlights importance of aggregated approaches to better understand systemic mechanisms of health deterioration in long-living individuals.
This study highlights the ability of Sirt4 to regulate ATP levels via ANT2 and a feedback loop involving AMPK.
This study highlights the association between waist circumference , early postmenopause and late postmenopause , and severity of OSAS.
This study highlights the heterogeneity in cognitive aging and provides evidence that most elderly maintain memory function as they age.
This study highlights the importance of differentiating aspects of social relationships to evaluate their unique associations with cognitive aging.
This study highlights the importance of prompt diagnosis and subsequent lifesaving treatment.
This study highlights the importance of the plantarflexors for mobility in older adults and provides understanding of possible mechanisms of age-related decline in mobility.
This study highlights the importance of understanding heterogeneous social relations and developing tailored interventions to promote social connectedness and mental health in LGBT older adults.
This study highlights the individual adjustment of space , and the integrated location in existing urban settings near nature.
This study highlights the need for greater dietetic advocacy in using validated nutrition screening tools to ensure malnutrition is identified.
This study highlights the need for intervention and health support for Chinese elders.
This study highlights the potential benefits of next-generation sequencing as a reliable , cost and time efficient , diagnostic , and research tool for ALS.
This study highlights the potential for such a program in fields such as pharmacology , genomics , and bioinformatics.
This study highlights the potential genetic complexity of Mendelian PD.
This study hypothesised that age would not affect body temperature and heat loss effector responses to short-term exercise-heat acclimation in trained subjects.
This study hypothesized that a scarcity of available energy induces the decline in customary walking speed with aging and disease.
This study hypothesized that different plasma-coating functional groups determine MWCNT neoplastic transformation potential.
This study identified all respondents who answered abdominal pain questions at an initial and follow-up survey.
This study identified and quantified airborne THS pollutants available for respiratory exposure , identified potential environmental tracers , and estimated health impacts to nonsmokers.
This study identified @number@ transcripts differentially abundant in acute phase of heart failure versus healthy aged subjects.
This study identified the most important factors that must be evaluated to identify frailty syndrome in a socially vulnerable population in the context of poverty.
This study identifies a previously unrecognized population with high risk for OSA.
This study identifies graduate students ' needs in preparation for a professional career in gerontology.
This study identifies independent predictors for a DC and determines what is the proportion of malnourished patients seeing a dietitian.
This study identifies patterns of growth and maturation in the pubic symphysis to derive more precise age estimates for individuals under @number@ years of age.
This study identifies risk and protective factors for falls among older , community-dwelling African Americans.
This study identifies the key factors associated with outpatient general practitioner ( GP ) , nursing or psychiatric healthcare utilization ( HCU ) within prisons.
This study illustrates that both the type and intensity of activity should be considered when selecting an accelerometer for characterizing impact events.
This study illustrates that environmental context triggers current concerns and determines , in part , the frequency and content of mind-wandering.
This study illustrates the increasing healthcare costs related to the growing burden of cardiovascular disease in sub-Saharan Africa.
This study implicates that DNA methylation can be an available biological marker of age-prediction.
This study included all elective ICU admissions with expected ICU stay of more than @number@ hours and all emergency admissions from September to @date@ .
This study included a population-based sample of @number@ U.S. centenarians from the Georgia Centenarian Study and @number@ Japanese centenarians from the Tokyo Centenarian Study.
This study included light microscopy , with hematoxylin and eosin and PAS stains , and fluorescent microscopy.
This study included @number@ Lebanese adolescent ( @number@ ± @number@ years old ) boys.
This study included @number@ older women ( age 60-90 years ) .
This study included @number@ participants ( @number@ men and @number@ women ) aged @number@ yr and older.
This study included @number@ participants ( @percent@ women ) .
This study included @number@ patients , aged 33-63 years ( the average age was @number@ ) with Fitzpatrick skin type II and III.
This study included @number@ sporadic MSA patients from the Department of Neurology , West China Hospital of Sichuan University.
This study includes @number@ adults in population-based cross-sectional data using the Korea National Health and Nutrition Examination Survey 2008-2011.
This study includes @number@ persons whose mean age was @number@.3 + / -6.6 years.
This study indicated a link between antisaccade performance and the ability to drive.
This study indicated that hearing aids are of potential benefit to many local residents.
This study indicates that a substantial part of the variation in tooth loss is explained by genetic as well as environmental factors shared by co-twins.
This study indicates that caregivers can benefit from receiving professional support via asynchronous e-mails and a dedicated information web site.
This study indicates that fruits are a valuable source of nutrient irrespective of the form of delivery in elderly and young adults.
This study indicates that PPARγ maintains pulp homeostasis through the regulation of autophagy molecules during the life span of HDPCs.
This study indicates that these three aging methods should be used in conjunction with other techniques.
This study indicates the need to further evaluate the differences in skin response to daily exposure to strong sun among various ethnic-origin inhabitants.
This study informs the potential content of interventions to promote engagement in sun protection behaviors among U.S. Hispanics.
This study initially set out to trace the full length of individual fibrils in adult human tendons , using serial block face-scanning electron microscopy.
This study intended to identify the impact of hearing loss in the social life of the elderly.
This study intends to fill in this research gap.
This study intends to gather and increase available data on pain and pain assessment as well as identify potential improvement possibilities.
This study investigated age-related and fall-risk-related differences in the ability to make visually guided reactive stepping adjustments during locomotion.
This study investigated age-related changes in muscle co-activation and spatio-temporal parameters during gait and identified the relationship between muscle co-activation and gait speed.
This study investigated associations between SUD and health problems in a prison population ( men and women ) .
This study investigated associations between variables of trunk muscle strength ( TMS ) , spinal mobility , and balance in seniors.
This study investigated bone marrow perfusion at proximal femur varying with bone mineral density ( BMD ) and aging over @number@ years.
This study investigated differences on these issues between caregiving and non-caregiving participants.
This study investigated discordance and socio-demographic factors that explain concordance.
This study investigated explicit knowledge of autobiographical memory functions using a newly developed questionnaire.
This study investigated how age and high-frequency audibility affect this Incongruency Advantage ( IA ) effect.
This study investigated how age , sex , and ethnicity may modify the interplay of subclinical inflammation and obesity in nationally representative contexts.
This study investigated how aging compromises the control of saccades and eye-hand coordination when accuracy constraints and termination requirements of hand movement are altered.
This study investigated how motion of the entire foot segment influences the toe trajectory.
This study investigated how older people evaluate their life when facing disease and disabilities.
This study investigated how perceived stress , social support , and home-based physical activity affected older adults ' fatigue , loneliness , and depression.
This study investigated how the stability against backward balance loss is affected by aging and intensity of perturbations.
This study investigated if AZM is effective for the treatment of aspiration pneumonia.
This study investigated if phosphorylation of H2A.X in peripheral blood mononuclear cells ( PBMCs ) is associated with cardiometabolic risk in nondiabetic individuals.
This study investigated interactions between aging and AUD in cerebral white matter integrity using diffusion tensor imaging ( DTI ) .
This study investigated maturational differences of selective auditory attention effects on transient evoked responses and 40-Hz auditory steady-state responses between children and adults.
This study investigated needs and psychological distress perceived by and / or quality of life of elderly cancer patients.
This study investigated possible correlations between apathy and cortical atrophy in @number@ individuals with mild cognitive impairment and @number@ clinically normal elderly.
This study investigated ( post ) adolescent brain maturation captured by two independently but simultaneously recorded neuronal signals : EEG and fMRI.
This study investigated potential explanations for these increased risks by evaluating random aneuploidy and senescence rates in amniocytes from fetuses with aneuploidy.
This study investigated sex differences in the relationship between the magnitude of the acute stress-induced salivary cortisol response and memory performance among middle-aged people.
This study investigated surgical outcomes and postoperative QOL in octogenarians who underwent cardiac valvular surgery.
This study investigated the abundance of protein markers for mitochondrial dynamics and mitochondrial content in older adults compared to young adults.
This study investigated the age-related apoptotic changes occurring in the gracilis muscle in humans between @number@ and @number@ years of age.
This study investigated the age-related changes in afferent feedback through the recording of reflex responses during voluntary muscle activation.
This study investigated the age-related changes in muscle quantity and quality in the trunk and limbs of women.
This study investigated the anatomical distribution of gray matter ( GM ) brain deficits in aged patients with ongoing schizophrenia.
This study investigated the antioxidant and antiphotodamage activity and mechanisms of N-phenethyl caffeamide ( K36 ) in human skin fibroblasts.
This study investigated the association between bone quality and components of metabolic syndrome in an elderly population.
This study investigated the association between physical frailty and multiple domains of QoL in community-dwelling older people.
This study investigated the association between PTH and structural and functional changes of the heart and arterial wall in a cohort of very elderly individuals.
This study investigated the associations among education , hemoglobin A1c ( HbA1c ) , and subsequent mortality in adults with diabetes.
This study investigated the associations between Internet use and cancer-preventive behaviors among older adults.
This study investigated the autonomic and haemodynamic responses to different aerobic exercise loads , with and without blood flow restriction ( BFR ) .
This study investigated the cardiac autonomic modulation by HRV analysis in community-dwelling elderly women classified as non-frail , pre-frail and frail.
This study investigated the central factors associated with maximal walking speed among older people.
This study investigated the characteristics of care arrangements in older long-term LAT couples and elicited personal comments about intra-couple care.
This study investigated the clinical characteristics and performed a molecular analysis of PHP and PPHP.
This study investigated the clinical outcomes of and costs incurred by older patients with AMI and metabolic syndrome ( MS ) in hospital.
This study investigated the comorbidities associated with dementia in the elderly population aged @number@ years and over in Taiwan.
This study investigated the differences between the kinematics and kinetics of repetitive lifting in two groups of handlers of different ages.
This study investigated the effectiveness of acupuncture on sleep quality of elderly with dementia.
This study investigated the effect of aging on lower limb joint power and work during gait.
This study investigated the effect of attending pre-school on mucosal immunity.
This study investigated the effect of Cordyceps sinensis oral liquid ( CSOL ) on the lifespan of Drosophila melanogaster ( fruit fly ) .
This study investigated the effect of Pilates exercise on physical fall risk factors @number@ months after an initial 5-week Pilates intervention.
This study investigated the effects of a brief bout of isometric exercise via handgrip on narrative and visuospatial episodic memory in healthy elders.
This study investigated the effects of aerobic exercise training on plasma ADMA concentrations and arterial compliance in postmenopausal women.
This study investigated the effects of age and hearing loss on perception of accented speech presented in quiet and noise.
This study investigated the effects of age and inactivity due to being chronically bedridden on atrophy of trunk muscles.
This study investigated the effects of aging and localized muscle fatigue on the neural control of upright stance during small postural perturbations.
This study investigated the effects of dementia on standing postural adaptation during performance of a visual search task.
This study investigated the effects of early- to midlife musical training on cognition in older adults.
This study investigated the effects of long-duration heavy alcohol consumption on intracortical bone remodeling in a non-human primate model.
This study investigated the effects of long-term in vitro expansion on the stability and function of MSCs.
This study investigated the effects of the FDMS regimen with the Wun-Jo trainer on measures of strength , flexibility , and balance in older individuals.
This study investigated the experiences of dyads taking both approaches.
This study investigated the feasibility and effectiveness of a bespoke Kinect stepping exergame in an unsupervised home-based setting.
This study investigated the fracture resistance of three different zirconia fixed partial dentures ( FPDs ) with different cementation methods.
This study investigated the impact of aging on audio-visual speech integration.
This study investigated the impact of attention on the sensory and motor actions during postural recovery from underfoot perturbations in young and older adults.
This study investigated the impact of psychosocial status on balance among @number@ Latino seniors after a twice-a-week , 12-week TC exercise program.
This study investigated the influence of age on the relationship between work characteristics and workers ' work motivation and job satisfaction.
This study investigated the influence of egocentric and allocentric viewpoints on a comparison task of length estimation in children and adults.
This study investigated the meanings and etiologies of hallucinations in persons with dementia.
This study investigated the molecular prevalence of Trypanosoma lewisi and T. evansi in wild rodents from Cambodia , Lao PDR and Thailand.
This study investigated the pharmacological properties of faster aspart in elderly subjects with type @number@ diabetes mellitus ( T1DM ) .
This study investigated the potential association between the mtDNA C150T polymorphism and longevity in a Han Chinese population.
This study investigated the potential influence of fluid intelligence and processing speed on the selective age-related decline in proactive control.
This study investigated the preferences for aging-in-place and its contributing neighborhood factors among low-income Chinese elderly in a metropolitan city.
This study investigated the prevalence and RFs for PN / SPN in ART-experienced patients enrolled in clinical salvage therapy studies.
This study investigated the prognostic factors in patients with incarcerated hernias.
This study investigated the relationship between age-related declines in muscle thickness of the lower extremities and daily physical activity in elderly women.
This study investigated the relationship between a magnetic resonance imaging ( MRI ) -derived biomarker associated with preclinical AD and postoperative delirium.
This study investigated the relationship between cancer and later-life cognition using nationally representative data.
This study investigated the relationship between childhood misfortune and 10-year change in health and whether this relationship was mediated by the quality of social relations.
This study investigated the relationship between glycemic variability at multiple time scales , brain volumes and cognition in type @number@ DM.
This study investigated the role of testosterone replacement therapy ( TRT ) in prostate safety and cancer progression.
This study investigated the role of toll-like receptor @number@ ( TLR4 ) in orosensory detection of dietary lipids and sugars.
This study investigated the role of YAP in breast cancer cells under nutrient deprivation ( ND ) .
This study investigated the subjective needs of patients with FXTAS and their family caregivers , by utilizing Q-sort methodology.
This study investigated the trajectories and neural basis of these component processes of WM functions in aging.
This study investigated the use of chemotherapy and survival in elderly patients with metastatic pancreatic cancer.
This study investigated the validity and reliability of the Microsoft Kinect @date@ as a potential inexpensive gait analysis tool.
This study investigated to what extent mobility factors explained older people's HRQoL when age , gender and functional ability ( ADL ) were controlled for.
This study investigated whether 25 ( OH ) D levels are related to anxiety symptoms in older persons , both cross-sectionally and over time.
This study investigated whether AIT influences functional capacity by modulating hemorheological / hemodynamic functions in HF patients with / without anemia.
This study investigated whether BD patients with VR demonstrate stronger apparent age-related decline in inhibitory performance and processing speed ( PS ) .
This study investigated whether fasting glucose was an indicator of nocturnal hypoglycemia in elderly male patients with T2DM.
This study investigated whether haematological markers differ between young and masters marathon participants , running at similar performance levels.
This study investigated whether it is possible to boost positive affect and associated positive biases in this age group using cognitive training.
This study investigated whether LA might be associated with increased cerebrospinal fluid ( CSF ) pulsatility linked to arterial hypertension.
This study investigated whether multimorbidity has a synergistic or cumulative impact on SRH.
This study investigated whether recognition of time-compressed speech predicts recognition of natural fast-rate speech , and whether this relationship is influenced by listener age.
This study investigated whether sclera could act as a surrogate tissue for Raman-based investigation of pathogenic AGEs in Bruch's membrane.
This study investigated whether the ACTN3 R577X polymorphism affects fitness status using a battery of tests in a large Japanese cohort.
This study investigated whether the cortisol awakening response ( CAR ) is related to memory performance among older adults.
This study investigated whether these difficulties are associated with deterioration in the representation of space in the auditory cortex.
This study investigated whether the three classical lens crystallins , namely α- , β- , and γ-crystallins , exist in mouse and human corneas.
This study investigated which characteristics of widowed mothers and adult children predict coresidence.
This study investigates differences in social support and nursing home admission by rurality of residence.
This study investigates how HE modulates erythrocyte rheological properties and further explores the underlying mechanisms in the hemorheological alterations.
This study investigates , in older people , the predictors of habitual PM performance in a naturalistic setting.
This study investigates practical experiences of staff and participants in immunotherapy RCTs.
This study investigates seasonal variation in leg strength in a longitudinal repeated measures design concurrently with serum vitamin D and physical activity.
This study investigates the age-related differences in skeletal muscle mass ( SM ) , muscle strength and physical performance in mainland Chinese.
This study investigates the association between ADHD and cognitive functioning in older adults.
This study investigates the attitudes of first-year PA students regarding older adults and provides data on this underdeveloped area in the literature.
This study investigates the different features between younger and older patients in an adult population ( > 18 years ) .
This study investigates the extent to which self-consciousness of appearance is associated with distress and dysfunction in those over @number@ years old.
This study investigates the factors that play role in causing AD and how changes in cellular pathways contribute to AD.
This study investigates the heritability of ME and whether ME and depression share common genetic influences.
This study investigates the influence of aging on the dimensions of the pelvis and the L4 lumbar vertebra during adulthood.
This study investigates the information of available postmortem brain resources in Japan.
This study investigates the interplay among depressive symptoms , widowhood , gender , and social integration in a nationally representative sample of older Mexicans.
This study investigates the pathways through which low socioeconomic status ( SES ) contributes to a higher RHR.
This study investigates the potential of measures of transfer entropy in scalp EEG for effectively discriminating between normal aging , MCI , and AD participants.
This study investigates the relationship between age-disparate sex and HIV status among young women aged 15-24 in South Africa.
This study investigates the relationship between the DriveSafe and DriveAware assessments and restriction of driving.
This study investigates the role of TGFβ response in the process of chondrocyte dedifferentiation / redifferentiation.
This study investigates to what extent PHVs are provided to patients with characteristics of frailty.
This study investigates to what extent physical inactivity in older age is associated with reduced life expectancy among non-overweight and overweight / obese individuals.
This study investigates whether exercise regimens with / without hypoxia affect cardiac and muscular hemodynamics by modulating CPCs and angiogenic factors.
This study investigates whether lower IGF-1 concentrations are associated with prevalent and incident late-life depression over a 3-year period.
This study investigates whether older workers have adapted their preferred retirement age to the pension reforms aimed at extending working life.
This study is a case series conducted between @date@ and @date@ with the use of semi-cross-linked HA to correct tear trough deformity.
This study is a contribution to the small existing pool of state level research on Advanced Practice Registered Nurse ( APRN ) workforce supply.
This study is a first step at understanding the correlates of social network size and diversity among LGBT older adults.
This study is a first step in determining if incorporating more nutrient-dense foods into a high-fat diet can allay cognitive dysfunction.
This study is among the first analyses of gene-protein product relationships integrating multiplex-panel proteomics and targeted genes extracted from a GWAS array.
This study is an ecological study of time trend.
This study is a Phase IV , randomized , double-blind , placebo-controlled , monocenter clinical trial.
This study is a retrospective cohort study using a large electronic medical records system to collect and analyze surgical case data.
This study is based on a clinical unselected series of HHT patients with the whole spectrum of severity , independent of need for medical care.
This study is designed to determine the epidemiologic data of trauma in elderly patients and to contribute to the national trauma database.
This study is devoted to the analysis of trends in best-practice life expectancy across cohorts born in @number@ to @number@
This study is performed for predictive assessment of blood damage in bileaflet mechanical heart valves ( BMHVs ) with pediatric sizing and flow conditions.
( This study is registered at ClinicalTrials.gov under registration number NCT00413439. ) .
This study is registered with PROSPERO , number CRD42016036153.
This study is the first attempt to investigate the relationship between obesity and the older workforce.
This study is the first direct evidence of a modulatory effect of P-tau on brain AChE expression.
This study is the first to demonstrate a direct association between VEGF levels and a dimension of the TCI in healthy subjects.
This study is the first to demonstrate improvements in relationship quality following vardenafil therapy , in both patients and partners , using the PFB questionnaire.
This study is the first to explore brainstem volume change and deformations in AD.
This study is the first to look at the nutritional status of at-home patients with dementia in Africa.
This study is the first to report an association between diet and sarcopenia in people younger than @number@ years.
This study is the first to report the isolation of Acetoxyisovaleryl alkannin ( AAN-II ) from A. nobilis.
This study is the first to suggest a second negative consequence for the senescence-associated secretory phenotype.
This study is to make psychiatric nursing professionals aware of the problem of elder abuse and neglect.
This study is , to our knowledge , the first genome-wide interaction study ( GWIS ) to identify SNP×SNP interactions associated with HDL levels.
This study is to update the normative data of pubertal linear growth characteristics and distribution of age at menarche in healthy Chinese adolescents.
This study is useful for decision-making and public policy making.
This study lays a foundation for understanding human CM maturation and pathogenesis and can be instrumental in PSC-based modeling of adult heart diseases.
This study lends credence to counter-intuitive notions regarding HC / AG neurodegeneration.
This study lends support to the \ "catecholaldehyde hypothesis \ " that the autotoxic dopamine metabolite DOPAL plays a pathogenic role in PD.
This study links mitochondrial haplogroups with ancestry-associated differences in metabolic rate and energy expenditure.
This study longitudinally investigated bilingual advantages on episodic memory recall , verbal letter and categorical fluency during the trajectory of life.
This study may contribute in developing new potential diagnostic tests , interventions and treatments.
This study may push for eventual approval of prosthetic valves resized for the pediatric population.
This study measured listener sensitivity to increments of a target inter-onset interval ( IOI ) embedded within tone sequences that featured different rhythmic patterns.
This study measured the effect of a wearable camera , SenseCam , on older and younger adults ' memories of recently experienced everyday events.
This study measures anger in caregivers and analyzes its predictors.
This study objectively quantified sedentary behaviour and ambulatory activity outcomes in retired and non-retired older , community-dwelling adults.
This study occurred during 2007-2009 in @number@ of @number@ counties in Kentucky.
This study occurs roughly @number@ years after a similar survey , and provides a timely update.
This study offers additional insight into the early functional integration of neural networks in PD.
This study offers evidence that CGGT holds promise for treatment of CG in older adults and merits inquiry in other populations.
This study offers normative data and documents the effect of stunting , wasting , and underweight on the bone properties measured by QUS.
This study planned to document survival in patients with primary and secondary tumors causing SCI admitted to a spinal rehabilitation unit over a 12-year period.
This study precisely quantifies prior claims of reduced DA functionality with age.
This study predicted the incidence of malignant mesothelioma in South Korea over the next @number@ years using an age-period-cohort ( APC ) model.
This study presents analyses of qualitative data collected during a 36-week cross-over pilot clinical trial in @number@ individuals.
This study presents a range of normal adult straw drinking speeds and discusses clinical applications.
This study presents craniofacial trauma injury patterns and treatment in an elderly population at a major urban trauma center.
This study presents the association of active antioxidants substances in a multifunctional cosmetic formulation with established efficacy against signs of aging.
This study presents the Circadian Energy Scale ( CIRENS ) , a very short and simple chronotype measurement tool based on energy.
This study presents the first update of the Cognitive Performance Scale ( CPS ) in @number@ years.
This study presents the results of a blind test of the revised auricular surface aging method developed by Buckberry and Chamberlain.
This study proposes a magnetic bead-based immunoassay using a secondary antibody to label negatively charged DNA fragments for signal amplification.
This study proposes an approach whereby structural and connectomic information can be combined to estimate PBA as an early biomarker of brain aging.
This study proposes a systematic reduction of the spatial information using ontology-based hierarchical structural relationships.
This study proposes a wearable , wireless , battery free ultra-high frequency ( UHF ) smart sensor tag module for falling and activity detection.
This study protocol describes a longitudinal cohort survey study that includes a baseline data collection and a 3-year follow-up.
This study provided a strong basis for the future study aiming at contributions of miRNAs induced by oxidative stress in AD.
This study provided evidence of the capability of the bioimpedance based method for assessing the wound status.
This study provided guarantees for the usage of the CRS in research.
This study provided no supporting evidence for the validity of either subjective online screening measure assessed.
This study provides a basis for further investigation of the links between oxidative stress and circadian rhythms in the neurobiology of BD.
This study provides a clearer understanding of factors influencing career choice among clinical neuroscientists in China.
This study provides a convenient and effective method to measure protein using a semiconductor sensor.
This study provides a novel mechanism for the positive effects of Q3GA on neurogenesis and suggests its therapeutic potential in neurodegenerative diseases.
This study provides a novel mechanism underlying SFN-induced proteasome activity.
This study provides an overview of all risk factors for falls of older citizens.
This study provides a platform to investigate molecules with similar structure to tiron as potent and clinically relevant antioxidants.
This study provides a quantitative assessment of the changes in scleral stiffness and collagen fiber alignment associated with diabetes.
This study provides a quantitative basis for future policy decisions to serve this need.
This study provides a theoretical framework on which future research on treatment-emergent suicidality in clinical populations could be based.
This study provides benchmarking information about the current status of wound management in Denmark and suggests how improvements might be achieved.
This study provides evidence for age-related functional decline in visual and auditory processing , and regional alterations in functional brain processing , using non-invasive neuroimaging.
This study provides evidence for functional changes in the reward system which may underlie typical adolescent behaviour.
This study provides evidence for recent theoretical accounts considering reduced hearing level as an important explanatory factor of poor auditory-verbal STM performance in older adults.
This study provides evidence in support of attempts to theorise health lifestyles in terms of collectivities.
This study provides evidence that AIMs may have anticancer effects on human cancer cells.
This study provides evidence that obesity influences age driven epigenetic changes , which provides a molecular link between aging and obesity.
This study provides evidence that PEAL might be useful for the treatment of leukemia.
This study provides evidence that self-efficacy beliefs buffer against the negative effects of low educational attainment on executive functioning.
This study provides further evidence for an age-related decline in proprioception at the level of the hand.
This study provides further evidence of an inverse association between cancer and AD.
This study provides further evidence on the link between subclinical cardiac structural changes and cognitive decline in older subjects.
This study provides further evidence that older people may be less sensitive to stress and stress-induced cortisol response effects on memory processes.
This study provides further evidence that those in advanced age are at risk of undernutrition.
This study provides insight into long-term health outcomes and cost-effectiveness of a tailored PA intervention among adults aged over fifty.
This study provides insights into the benefits of , and what it means for , older men with prostate cancer to regularly exercise individually.
This study provides much needed insight into the function of DHEAS.
This study provides new insight into the dynamics of CA and may be useful in identifying the risk for dCA processes.
This study provides new insight into the molecular mechanisms by which RPIA overexpression can induce oncogenesis in HCC.
This study provides new insights into mechanisms regulating MSC aging and may have implications for therapeutic application to reduce age-associated MSC pool exhaustion.
This study provides potential therapeutic targets for expansion of adult β cell mass.
This study provides rationales for new therapeutics of protecting the aging of kidneys.
This study provides relevant insights into the HCU patterns of a marginalized and understudied population.
This study provides strong support for an association of the APOE gene with human longevity.
This study provides the first in vivo evidence of genomic region-specific repair in mammals.
This study provides the first report of the overlapping community structure of the structural network of the human brain.
This study provides the rationale to further investigate the optimal CVP target during this surgery.
This study quantified activity and sedentary behaviour in older , community-dwelling adults.
This study quantified the association between PA and WM integrity in adults over @number@
This study quantifies the historic ( May to @date@ @number@ ) heat-morbidity relationship in the most populous Pacific Northwest County , King County , Washington.
This study raises several important avenues for future research related to the physiologic functioning of LGB populations and gender diversity more broadly.
This study received funding through the Capital Region Research Fund and by EU-regional funding.
This study recruited @number@ subjects from six sites in China.
This study reevaluates and extends this model by considering how adaptive capacities influence subjective aging and depressive symptoms in late adolescence and young adulthood.
This study reinforces the concept that healthy habits have a direct effect on erectile function.
This study relies on eye tracking technology to investigate how humans perceive others ' feeding actions.
This study replicates the association between rs12456492 variant and risk of developing PD in a Han Chinese population.
This study reports an elderly patient who was diagnosed with rifampicin-resistant lepromatous leprosy.
This study reports a novel MATR3 mutation and stresses on the importance to consider MATR3 mutation as a possible etiology of ALS.
This study reports a potent covalent MAGL inhibitor , SAR127303.
This study reports a secondary analysis of WHOQOL-OLD pilot study , which was collected simultaneously in @number@ centres.
This study reports results from histological observation of Purkinje cells in humans , non-human primates , and other mammals.
This study reports the characteristics and feasibility of these valves.
This study reports the induction of cellular senescence of human colon cancer cells HCT116 upon curcumin treatment.
This study reports the results of operative management of ankle fractures in the elderly , with regard to functional outcome and complication rates.
This study represents a replication of this earlier work using enriched cohorts and extending the analysis to include cognitive decline.
This study represents a unique attempt to trace the development of auxiliary syntax by using a longitudinal elicitation methodology.
This study represents a useful attempt to employ multiple indicators to build a comprehensive BA evaluation formula of aging populations.
This study represents the first N-glycan profiling of placental cell membrane proteins.
This study represents the first to examine CC in elderly subjects longitudinally.
This study represents the setup of a procedure for the proteomic analysis of platelets from children.
This study retrospectively reviewed @number@ patients with non-small cell lung cancers ( NSCLC ) who underwent pulmonary resection.
This study revealed a relationship between the fear of falling and perceived difficulty with grocery shopping.
This study revealed that fewer social support functions , and therefore less life satisfaction , were available for females than for males.
This study revealed that the prevalence of AMD in females was higher with female preponderance in ratio of @number@.5 : 1.
This study revealed transitioning goals and values , challenges encountered while transitioning , and key attributes of resilience that have aided in transitioning.
This study reviewed the evidence on physical activity / exercise interventions trialed with older people receiving a home care service.
This study screened neuropsychological abilities and explored group differences related to cardiac disease severity and neurological risk factors in adults with CHD.
This study seeks to better understand how technology influences interprofessional communication within a hospital setting based in the United States.
This study seeks to critically review the literature that evaluates PEG placement in this population.
This study seeks to determine the contributors to malnutrition at admission and evaluate its effect on LOS.
This study seeks to identify patient-related factors associated with lack of symptomatic improvement after endovascular iliac artery treatment in male veterans.
This study seeks to identify the consequences of a change in intergenerational coresidence on the depression level of the elderly.
This study seeks to improve the screening and diagnostic process by analysing communication between clinicians and patients during initial specialist clinic visits.
This study serves as a particularly important example of knowledge related to addressing aging-associated diseases and disorders that results from studies in long-lived mammals.
This study set out to determine whether two potential protein-sparing modulators ( eicosapentaenoic acid and vitamin D ) would attenuate immobilisation-induced changes in muscle characteristics.
This study sheds light on caregiving decision-making dynamics for the increasing aging population across cultures.
This study should be performed mainly in patients ≥55 years old or with risk factors to develop an AAA.
This study showed a potential relationship between lens fiber cell membrane protein genes and the development of age-related cataracts in the Chinese population.
This study showed excessive sympathetic nerve activities in patients with SMID.
This study showed gender differences in the level of physical activity and functioning that must be taken into account when planning intervention programs.
This study showed that antagonist torques were not responsible for age-related declines in KF and KE resultant torques.
This study showed that greater than @number@ % improvement in dilated pores was demonstrated in @number@ of @number@ patients after three sessions of laser treatments.
This study showed that the PDE4B gene was downexpressed in men with DS and cryptorchidism compared to normal controls and DS without cryptorchidism.
This study showed that the real clinical practices for LOH are very diverse , and a general consensus is needed.
This study showed that the SB-VCE provides accurate and reliable measurements of SITT under real-life conditions.
This study showed that younger men with higher physical activity and better physical fitness are less likely to suffer from erectile dysfunction.
This study shows a clear wealth gradient in disability among older English adults , especially for those with elevated depressive symptoms.
This study shows a good correlation for MUNIX between intra- and interoperator results in both normal controls and ALS patients.
This study shows a link between baseline increased pulse pressure or arterial stiffness with the prolongation of the PR interval with aging.
This study shows an excess mortality in men and in women younger than @number@ years who are treated for osteoporosis compared with the background population.
This study shows clinically meaningful increased resting state functional connectivity in PLS.
This study shows for the first time that MNF impairs GPR55-mediated signaling and , therefore , may have therapeutic potential in the management of cancer.
This study shows that cognitive measures provide valuable information regarding the predictive diagnosis of persons with MCI.
This study shows that ligaments and the vaginal wall of young women have similar mechanical behavior while those of older women differ.
This study shows that loss of balance among various members of the SOCS family proteins may contribute to pathophysiology of multiple sclerosis.
This study shows that low-grade inflammation and endothelial dysfunction contribute to reduced information processing speed and executive functioning in an older population.
This study shows that older people who are still working demonstrate better neuropsychological task performance.
This study shows that the IVIM perfusion estimates in the cerebral gray matter present a detectable deviation from the spherical model.
This study shows that the low-income elderly with disability but without adequate social protection are the most disadvantaged group.
This study shows that the simulation based on BMU activities has the potential to define and predict the morphological evolution of the vertebral body.
This study show that circCOL3A1-859267 regulate type I collagen expression in photoaged HDFs , suggesting it may be a novel target for interfering photoaging.
This study's objectives were to characterize sleep in a community without electricity in Haiti and to examine associations between measures of sleep and age.
This study sought to ascertain the experiences of the process of dying and death of health care professionals in a long-stay institution for the elderly.
This study sought to ascertain whether occupational noise-induced hearing loss ( NIHL ) increased the risk of falls requiring hospitalization among retired workers.
This study sought to assess glial and neuronal integrity in these regions in relation to subjective sleep disturbance in a healthy older sample.
This study sought to describe a single institution's experience treating arteriovenous malformations ( AVMs ) in elderly patients.
This study sought to determine how a preceding balance task and aging would affect the task performance and movement strategy.
This study sought to determine the association between these age-related factors and renal damage in patients with IgA nephropathy ( IgAN ) .
This study sought to determine the effects of smoking on mortality in older age.
This study sought to determine the prevalence and impact of pain in a nationally representative sample of older adults in the United States.
This study sought to determine the prevalence of concealment and identify demographic , clinical , and psychosocial correlates of concealment among lung cancer patients.
This study sought to discover the aerobic activity preferences among older Canadians.
This study sought to evaluate the resin microtensile bond strength ( MTBS ) stability of a leucite-reinforced ceramic after different ceramic etching protocols.
This study sought to examine the impact of an aerobic exercise intervention on verbal fluency in sedentary older adults.
This study sought to explore age-related changes in MR using an innovative visual tool and examine the developmental sensitivity of the task.
This study sought to explore the lived experiences of physically active prostate cancer survivors on androgen deprivation therapy ( ADT ) , who exercise individually.
This study sought to explore the relationship between anemia in children and levels of five minerals in blood.
This study sought to identify changes in cognitive performance with age and to investigate associations of cognitive performance with several key cognitively stimulating leisure activities.
This study sought to investigate changes in central hemodynamics during cycle exercise in young , middle-aged , and older men.
This study sought to understand how older adults make sense of the challenges of aging.
This study's preferred approach is an interprovincial comparison between Quebec and Ontario , used to analyze individual aspects of baby boomers ' financial positions.
This study's purpose was to analyse the association between excess weight and health service use / costs in the older population in Germany.
This study's purpose was to examine the effect of aging on vertical postural control in the community-dwelling elderly.
This study stresses the need to support mobility older adults with ID as much as possible , in order to optimize independency in this group.
This study strongly suggests that reducing pathologic heterogeneity may enhance the application of genetic association studies to PD.
This study succeeded in implementing an appropriate version of the TMT for fNIRS and helps elucidating neural aging effects associated with this task.
This study suggested that fine microrelief on the skin surface hampers large wrinkles.
This study suggested that Fitts ' law applied for pointing movements of the elderly adults under different visual restriction conditions.
This study suggested that multifactorial gait analysis could be more informative than using gait analysis with only one test or one variable.
This study suggested that the DistEn would be a promising measure for prompt clinical examination of cardiovascular function.
This study suggests an association between elder homicide and robbery , in which elders , due to their vulnerability , are a preferential target.
This study suggests an association between frailty and inflammation in older adults with cancer.
This study suggests a pathogenic link between neurofibrillary tangle load and aggressive behaviours in the hippocampus of dementia patients.
This study suggests a positive association between serum ferritin levels and BMD in elderly South Korean men without hematologic disorders.
This study suggests that ageing produces specific changes on the processing of nonverbal vocalizations.
This study suggests that aging may be associated with declines in large and small artery compliance that can be attenuated by habitual vigorous activity.
This study suggests that clinicians should consider older adults ' use of transportation in an attempt to encourage and maximize their participation.
This study suggests that CSF klotho concentrations are lower in females compared with males , in Alzheimer's disease , and in older versus younger adults.
This study suggests that developmental pathways in the wake of adversity may be partially determined by how individuals self-reflectively process significant life experiences.
This study suggests that diabetes is a common health problem in this area.
This study suggests that doenjang has antiobesity and antioxidative effects in overweight individuals with mutant alleles of PPAR-γ2.
This study suggests that DWI-based network measures may be a novel predictor of AD progression.
This study suggests that identification and quantitation of A2E from tissue extracts by chromatographic absorption spectroscopy overestimates the amount of A2E.
This study suggests that obesity is associated with higher UD radius , @date@ radius and total radius BMD values in Lebanese women.
This study suggests that retirement may be beneficial for blood pressure , waist circumference , and alcohol consumption in the Chinese context.
This study suggests that sub-MIC imipenem and pexiganan could be a good strategy to target the adhesion process during the infection cycle.
This study suggests that tau K280 acetylation is a potential target for drug discovery and biomarker development for AD and related tauopathies.
This study suggests that the accuracy of juvenile age estimation from the face alone is poor using simple visual assessment of images.
This study suggests that the activities of biological and synthetic oligomers are indistinguishable during early stages of Aβ oligomer-cell interaction.
This study suggests that the age-related increase in scleral stiffness is accelerated in eyes with diabetes , which may have important implications in glaucoma.
This study suggests that the estradiol / ERα / REA axis may be a feasible target in the management of recurrent vaginal candidiasis.
This study suggests that there are large numbers of men in the community whose testosterone deficiency is neither being diagnosed nor treated.
This study suggests the effectiveness of MT approach with working cycles in reducing behavioural disorders of severely demented patients.
This study suggests the fibrofatty infiltration in cardiac allografts is a clinically different entity from arrhythmogenic right ventricular dysplasia and has an unknown etiology.
This study supports a bidimensional model of cultural adaptation among older Chinese Canadians.
This study supports an association between hypoalbuminaemia and poorer outcome for patients with NOF fractures.
This study supports the hypothesis that inflammation and immune-mediated mechanisms are involved in the pathogenesis of AMD.
This study supports the notion that there is a need for assessment of caregiving reactions in carers of frail older people.
This study tested the association of single nucleotide polymorphisms in the fibrinogen α ( FGA ) and β ( FGB ) genes with cognitive performance.
This study tested the efficacy of a nurse-led reminder program through email ( NRP-e ) to improve CVD risk factors among hypertensive adults.
This study tested the hypothesis that cumulative benefits of LTPA across mid-life on grip strength will have emerged by age 60-64.
This study tested the hypothesis that high-intensity exercise has the ability to produce free radicals that may be capable of causing DNA damage.
This study tested the hypothesis that hyperthermia-induced changes in left ventricular systolic and diastolic function are attenuated in older adults when compared with young adults.
This study tested the hypothesis that inflammation and oxidative stress determined carotid IMT in patients with OSA.
This study tested the hypothesis that memory impairment in patients with ALS is related to hippocampal degeneration.
This study tested the hypothesis that part of the age-related decline in performance on executive function tasks is due to a decline in episodic memory.
This study tested the hypothesis that the relationship between neuroticism and physical functioning is stronger in older people compared with younger and middle-aged adults.
This study tested the impact of a complementary health approach to quality of life in menopausal women.
This study tested those interpretations by examining relationships between Stroop performance , behavioral disinhibition , and frontal lobe atrophy.
This study tested whether there are age differences in event segmentation at the intersection of continuous activity and narrative : narrative film.
This study therefore aimed to shed more light on neural adaptations in response to balance training in older adults.
This study therefore aims at building our best practice to enhance the capacity of residential care homes in providing culturally appropriate end-of-life care.
This study therefore assesses the association of mobility impairment , social engagement , and life satisfaction among the older population in China.
This study therefore provides a fresh understanding of aging and diseases , and may lead to effective prevention and therapies.
This study thus aimed to explore the influence of adapted sports on quality of life in adult wheelchair users.
This study translated the ASD to Mandarin and examined its psychometric properties.
This study underlines the importance of considering the role of the older person's decisional power in the consumption of these medications.
This study underscores the importance of mitophagy in promoting a healthy pool of mitochondria and in preventing neurodegeneration and premature aging.
This study undertakes a survival analysis of elderly persons in China using Chinese Longitudinal Healthy Longevity Survey 2002-2008.
This study used a correlational approach to clarify the mechanisms involved in modulation coding.
This study used a dual-tasking paradigm to determine if performance decrements are observed in gait or working memory when performed concurrently.
This study used a phenomenological approach.
This study used a qualitative grounded theory design following the approach of Glaser ( @number@ ) .
This study used a three-item loneliness scale to determine the prevalence of loneliness.
This study used Balb / c mice to examine the longevity of Zygocotyle lunata in a murine host.
This study used data from the Age Gene / Environment Susceptibility-Reykjavik study , which recruited @number@ participants aged 66-98 years in 2002-2006.
This study used diffusion tensor imaging ( DTI ) to characterize brain microstructural changes in HIV-infected individuals with and without cerebrovascular risk factors.
This study used experience-sampling to examine the developmental course of emotional experience in a representative sample of adults spanning early to very late adulthood.
This study used functional Magnetic Resonance Imaging ( fMRI ) to investigate age related differences in the control of grip force magnitude.
This study used MCE in the quantification of complexity between RRI and PTT time series.
This study used prospective data from @number@ adults , @number@ to @number@ years old , collected over a 12-year-period from the Health and Retirement Study.
This study used the Human-Centered Design approach , which embraced three main phases - observation , identification , and ideation.
This study used the Korea Welfare Panel Study data 2005-2014 with the final sample of @number@ who were @number@ years and older.
This study used the National Health Insurance Service-Cohort Sample Database from @number@ to @number@ ( n = 23 , 856 ) .
This study uses data collected from @number@ elderly women living in urban areas.
This study utilizes both survey questionnaires and semi-structured focus group methods to investigate the feelings of loneliness among U.S. Chinese older adults.
This study validated the genes that are associated with TLR and NLR signaling pathways from different types of patient-derived cells.
This study was a cross-sectional and corelational survey , and the data were collected by multistage stratified sampling.
This study was aimed at assessing the relationships between cataract maturity and AH lipid peroxidation markers and enzymatic antioxidants.
This study was aimed at collecting data for measuring and interpreting performance change on a memory test for verbal material.
This study was aimed to evaluate this issue.
This study was aimed to explore whether carbocysteine , in a human bronchial epithelial cell line ( 16-HBE ) , counteracted some pro-inflammatory CSE-mediated effects.
This study was aimed to investigate the effect of human PON1 overexpression in mice on cholesterol efflux and reverse cholesterol transport.
This study was aimed to investigate whether the surgical risk calculator is suitable for predicting postoperative complications in elderly Chinese patients with hip fractures.
This study was approved by the Ethics Committee of the Chinese Academy of Medical Sciences and the Peking Union Medical College Hospital.
This study was approved by the Institutional Review Board.
This study was a retrospective review of the medical records of @number@ consecutive patients who underwent free flap reconstructions.
This study was carried out in a primary care unit and various households , among subjects aging @number@ years or older.
This study was carried out to determine whether vitamin D and calcium supplementation altered serum sclerostin levels in healthy older adults.
This study was carried out to estimate the prevalence and economic burden of HF in order to understand its impact on our society.
This study was carried out to investigate the anticancer effect of MHY218 , a hydroxamic acid derivative , in HCT116 human colon cancer cells.
This study was conducted among all subjects ( n = 160 ) aged @number@ years and older who lived in two nursing homes of Japan.
This study was conducted from @number@ to @number@ using structured questionnaires on retirement , morbidities , and health-related behaviors.
This study was conducted in National hospital for tuberculosis and renal transplantation ( RT ) in Japan.
This study was conducted in order to determine the symptoms and perception of menopause , as well as factors affecting and influencing this perception.
This study was conducted on @number@ car auto repair workshop workers exposed to occupational hazards and @number@ controls without this kind of exposure.
THis study was conducted to analyze the molecular mechanisms responsible for anti-proliferation effects of glaucocalyxin A in cultured MCF-7 and Hs578T breast cancer cells.
This study was conducted to epidemiologically describe the health status of the elderly population of Iran.
This study was conducted to evaluate phagocyte function in patients with age-related chronic inflammatory conditions.
This study was conducted to investigate the masticatory function and its determinants among a large sample of Iranian adults.
This study was conducted using a questionnaire survey with one-to-one interviews during January and @date@ .
This study was cross-sectional and therefore additional longitudinal studies are needed to confirm our findings.
This study was designed to assess the effectiveness of a Smartphone-based audio-biofeedback ( ABF ) system for improving balance in older adults.
This study was designed to compare patients referred to the emergency department ( ED ) for AFs , UFs or syncope.
This study was designed to determine the effect of aging and production of oxygen-derived free radicals on expression of BubR1.
This study was designed to determine the prevalence of MCI in the elderly in the Hebei province , China , and explore its related factors.
This study was designed to elucidate the effects of co-treatment with NADPH and NOX inhibitor apocynin on ischemia / reperfusion-induced brain inflammation and neuronal injury.
This study was designed to elucidate the roles using peripheral blood mononuclear cells from healthy donors and patients with oral candidiasis.
This study was designed to estimate the prevalence of MCI and explore the possible risk factors including gender disparities among community-dwelling older individuals.
This study was designed to evaluate the impact of patient age on hepatic regeneration.
This study was designed to examine postural tremor in healthy older adults , PD and ET using standard linear and non-linear metrics.
This study was designed to explore the impact of Yoga and Meditation based lifestyle intervention ( YMLI ) on cellular aging in apparently healthy individuals.
This study was designed to identify the bioactive phenolics in detoxified Rhus verniciflua Stokes ( DRVS ) that may protect human skin against oxidative stress.
This study was designed to investigate changes in fundamental frequency ( F0 ) across the life span in Persian speakers.
This study was designed to investigate the antioxidant ability of GEB and its antiaging effect on human dermal fibroblast cells ( HDF ) .
This study was designed to investigate the effects of ageing on soleus ( SOL ) H-reflex modulation during dynamic muscle actions.
This study was designed to investigate the LUTS after endocrine therapy and their effects on the quality of life in elderly patients with PC.
This study was designed to investigate the prevalence and prognostic value of electrocardiographic abnormalities in Trypanosoma cruzi infected and noninfected older adults.
This study was designed to investigate whether anthocyanin-rich purple corn extract ( PCE ) prevented glomerular angiogenesis under hyperglycemic conditions.
This study was designed to provide insight into their unique treatment preferences , including the use of traditional Chinese medicine ( TCM ) .
This study was designed to test the hypothesis that greater muscle mass in older adults is associated with lower all-cause mortality.
This study was designed to test the hypothesis that MP alters contrast between an object and its background , and thus alters the object's detectability.
This study was done to find out whether any relation exists between these @number@ variables in elderly.
This study was initiated from @number@ until @number@
This study was made with the help of @number@ women in menopause who applied to Akdeniz University Research and Application Hospital in @date@ .
This study was performed to characterize and map the fine specificity of T cell responses to NC16a.
This study was performed to clarify the relationship between inhalation procedure and sex difference in elderly patients with asthma.
This study was performed to evaluate if Portuguese patients with familial amyloidosis and in a blood donors population ( control group ) .
This study was performed to examine whether exposure to CB alters various biological parameters of parents and their progeny.
This study was performed to investigate the anti-inflammation and tumor preventing capacity of betaine on colitis-associated cancer in mice.
This study was registered at clinicaltrials.gov as NCT02351661.
This study was registered at www.anzctr.org.au as ACTRN12614000655640.
This study was registered at www.controlled-trials.com as ISRCTN46718296.
This study was the first to evaluate the relationship between aging and ISR using the FAERS database.
This study was the first to explore midlife motivational abilities as a predictor of the progression of apathy and depression in MCI and AD.
This study was the first to use a robotic device to show the age effects on upper limb kinematics and establish norms in healthy children.
This study was therefore conducted to determine the prevalence , types and determinants of SD in a sample of Ghanaian men with urological conditions.
This study was therefore conducted to investigate the relationship between the spiritual attitude of the family caregivers of older patients with stroke and their burden.
This study was thus carried out to explore the association between edentulism and quality of life among older Ghanaian adults.
This study was undertaken to assess the accuracy of the Berlin questionnaire to diagnose OSA in a large healthy elderly population.
This study was undertaken to determine characteristics guiding choice of adjuvant therapy.
This study was undertaken to determine the reason for the change.
This study was undertaken to investigate the effectiveness of facial rejuvenation using a deep-plane facelift and other cosmetic procedures.
This study will also assist in identifying whether revisions of the PD-MCI criteria are required.
This study will be underpinned by the Health Belief Model with an emphasis towards self-efficacy.
This study will enable evaluation of the efficacy of milk-derived phospholipids for AAMI , and their mechanisms of action.
This study will evaluate My Tools @number@ Care ( MT4C ) by asking the following research questions : @number@
This study will test effectiveness of implementing Eat Walk Engage using a multi-site cluster randomised trial to inform transferability of this intervention.
This study yields standards for reference for the normal curvatures of the spine in the sagittal plane.
This subscale also correlated with the Dementia Questionnaire for Persons with Intellectual Disabilities.
This subsequently leads to apoptotic cell death resulting in CICI.
This substance may be formed by oxidation of , indicating that the bond between inorganic filler and organic matrix might be weakened after bleaching.
This substantially changes the distribution of human lifetime among different stages of the life cycle.
This substitution caused reduced p65 protein synthesis and diminished TNFα-induced expression of a selected group of NF-κB-dependent genes.
This suggested an alteration in membrane skeleton structure , which was confirmed by beta-actin release in cell lysates during ghost preparation.
This suggested a state of hypometabolism and vascular insufficiency along with an inflammatory condition during VaD.
This suggested that KIAA0319 participates in functions unrelated to neuronal migration.
This suggested that mitotic catastrophe was an alternative mechanism in cells resistant to apoptosis.
This suggested that the genetic contribution to control region mutations may be population specific.
This suggested that the molecular networks and their constituent modules collapsed along with AD progression.
This suggested that these results are in principle transposable to humans.
This suggestion is supported by evidence that the disruption of vitamin D pathways mimic amyloid pathology.
This suggests a compensatory mechanism is underway where local processing deficits are offset by recruitment of more dispersed cortical regions.
This suggests a deficit of the central executive rather than visuo-spatial memory deficits.
This suggests a disconnect between training and future practice pattern.
This suggests aging impacts on short-range summation mechanisms , potentially underpinned by larger summation areas for the perception of small moving stimuli.
This suggests a moderator role of @number@ recently conceptualized functions of PSS : perceived promotion of dependence versus autonomy.
This suggests an age-related shift toward emphasizing positive social information may be reflected in the recruitment of regions supporting forming impressions.
This suggests an asymmetrical change in the useful field of view that is lexical in nature.
This suggests a potential therapeutic role for autoantibodies , or , even better , a way to use them to prevent disease.
This suggests a protective effect of grapes against early pathologic metabolic decline.
This suggests a role for nutrition care in reducing LOS.
This suggests a role in the aging process , though causality is not yet clear.
This suggests common underlying genes predispose to kidney disease in mice and humans.
This suggests compensatory activation related to disturbance of frontosubcortical circuits.
This suggests different aspects of driving performance tap different resources.
This suggests early alteration in attentional control with rising levels of AD pathology.
This suggests GCH1 variants affect early PD risk through altered dopamine uptake , and aging alters how genetic factors contribute to disease development.
This suggests mechanisms of accelerated biological aging among the depressed , which can be indicated by a shorter length of telomeres.
This suggests separate underlying disorders and highlights the need for comprehensive evaluations to detect early deficits.
This suggests that ABCC2 activity is correlated with corrected gestational age and is highest at 1-2 years old.
This suggests that age-related diseases , lifestyle choices , and medications influence BMD rather than age per se.
This suggests that alpha dynamics plays an important role in the changes in listening behavior that occur with age.
This suggests that Ang II contributes to the ageing process by prompting mitochondrial dysfunction.
This suggests that an increase in tau oligomers levels occurs before individuals manifest clinical symptoms of AD.
This suggests that AQP4 expression was associated with amyloid deposition and astrocyte pathology in the Tg-ArcSwe mouse model of AD.
This suggests that as CR increases so does EF , which in turn improves FA.
This suggests that ASL can be used as a non-invasive tool to investigate brain maturation in neonates.
This suggests that assessment of QoL may be beneficial to clinicians in predicting deterioration in functional limitations among older patients receiving cancer treatment.
This suggests that boosting maternal-specific Ab by RSV vaccination may be a useful strategy to consider.
This suggests that calcium dysregulation may be associated with the pathogenesis of FSP.
This suggests that cerebellar involvement is secondary to cerebral involvement and can be due to network connection spread regardless of the primary pathology.
This suggests that cetuximab is certainly warranted in the treatment of advanced cSCC.
This suggests that children have a protective mechanism against the development of disease.
This suggests that diagnosis of MCI at any time has prognostic value.
This suggests that DLK1 ( PREF1 ) could be a useful marker to characterize human ASC.
This suggests that during novelty encoding , increased fMRI activity in the temporal lobe may relate to incipient AD processes.
This suggests that dynamic in vivo imaging of the central microcirculation enables the measurement of local microvascular stiffness with a commercially available medical device.
This suggests that early life is an important period in the determination of telomere length.
This suggests that effective public measures need to be developed to improve the prevention and control of hypertension.
This suggests that emotional valence , and not low-level image features , were responsible for the emotional bias in both age groups.
This suggests that exposed individuals show signs of accelerated erosion of telomeric ends from an early age.
This suggests that future studies should focus on the potential benefits of cognitive processes in auditory training.
This suggests that GDC-0853 could exacerbate a background finding in younger animals.
This suggests that GP is related to perceptual grouping via Gestalt laws.
This suggests that healthy older adults preserved their ability to adjust postural control to environmental demands.
This suggests that high heel use , especially in combination with additional weight , may contribute to increased OA risk in women.
This suggests that HIV induces inflammatory pathways that are associated with a pattern of accelerated aging and that anemia is a biomarker of these processes.
This suggests that , in future studies , more attention should be paid to individual differences among caregivers rather than caregiving status per se.
This suggests that leisure participation has an indirect effect on older people's adaptability.
This suggests that less positive processing may reflect vulnerability for future depressive symptoms.
This suggests that many of these proteins have other , as yet unknown functions.
This suggests that mild anemia and low Hb levels are independent , modifiable risk factors for frailty.
This suggests that more generous welfare states help to produce a more equitable distribution of wellbeing among older people.
This suggests that muscle activation patterns in gait mature at a later stage of childhood than do kinematic gait patterns.
This suggests that muscular recovery , from a transcriptional perspective , is incomplete @number@ h after endurance exercise involving muscle damage.
This suggests that musicianship strengthens brain-behavior coupling in the aging auditory system.
This suggests that NCC-related hippocampal atrophy takes a long time to develop.
This suggests that nicotine's action is complex , probably involving different neuronal circuits influencing each other through complicated interactions.
This suggests that obesity may be associated with axonal degeneration.
This suggests that older adults may become better at selecting their strategies in accordance with their goals.
This suggests that older age does not inevitably preclude cognitive proficiency.
This suggests that older musicians use a compensatory strategy to overcome age-related decline in peripheral and exogenous processing of acoustic information.
This suggests that older people are often active in constructing what they regard as ' healthier ' routines around alcohol use.
This suggests that osteocalcin is necessary for normal pituitary-gonadal axis function.
This suggests that our findings in patients may represent the extreme extension of the age-related response flexibility activation differences found in healthy subjects.
This suggests that parents ' critical behaviors exert a direct environmental effect on somatic symptoms in adolescent children.
This suggests that percentile rank estimates will be required to robustly define the limits of brain tissue volume in normal ageing and neurodegenerative disease.
This suggests that posttranscriptional mechanisms regulate miRNAs ' processing and / or stability to induce the rapid fluctuation in their levels.
This suggests that posttranscriptional mechanisms regulate miRNAs ' processing and / or stability to induce the rapid fluctuation in their levels.
This suggests that project-induced displacement is not as detrimental for the mental health of seniors as previous studies demonstrate it is for younger people.
This suggests that racial differences are not related to tissue characteristics or inherent nociceptor sensitivity.
This suggests that reduction in sensory vestibular innervation sensitivity is likely to play a pivotal role in the relief of dyspareunia.
This suggests that Rsv induces telomere maintenance factors like WRN helicase without affecting cell proliferation.
This suggests that significant amounts of the endogenous photosensitizers that mediate UVA-induced oxidative stress are located in the mitochondria.
This suggests that social security benefits can relax households ' budget constraints and allow wives to join their husbands in retirement.
This suggests that specific age-related DNA methylation changes may have quite a broad impact on gene expression in the human brain.
This suggests that talents involve an experience-dependent component in addition to genetically defined alterations of perceptual encoding.
This suggests that telomere length may identify subjects at increased risk of AD.
This suggests that telomeres measured from different tissues may have different associations with measures of body composition.
This suggests that the balance between the levels of proneurotrophin and neurotrophin must be tightly controlled.
This suggests that the Internet is an important social and health activity that contributes to lowering suicidal ideation in older adults.
This suggests that the maintenance of these chromosomal structures may be critically important for preventing , or delaying , senescence and aging.
This suggests that the mechanism and factors associated with IR in CKD may differ.
This suggests that the MIP did not adequately address the needs of the aging Georgian population where chronic illnesses are prevalent.
This suggests that the observed skew in T cell receptors is due to their amino acid usage , which is similar to that of BCRs.
This suggests that the p53 gene ( TP53 ) is important for apoptosis regulation during spermatogenesis , and may be associated with male infertility.
This suggests that the phasic release of NE in response to threatening stimuli may be diminished in older adults.
This suggests that these at-risk individuals should be targeted for HCV screening and treatment , given the availability of new highly effective HCV therapies.
This suggests that the Tf-2 / Tf-1 ratio could distinguish iNPH from Alzheimer's disease , and possibly other dementias.
This suggests that the toxicity depends at least to some extent on the overall multibasic character of this inhibitor.
This suggests that training in early childhood may be an important factor in the prevention of osteoporosis in later life.
This suggests that trajectories of increasing obesity past @number@ years of age pose a substantive threat to future gains in life expectancy.
This suggests that TTD largely approximates disability.
This suggests that users of these drugs may experience accelerated cognitive decline.
This suggests that visuotactile peripersonal space differs between older and younger adults.
This suggests that vit-D deficiency may contribute to the development of myocardial dysfunction in these patients.
This suggests that Vit-D deficiency might contribute to depletion of EPCs and endothelial dysfunction in patients with type @number@ DM.
This suggests that WM forgetting cannot be completely accounted for by the CL hypothesis.
This suggests that women's executive processes may benefit more from exercise than men.
This suggests the hypothesis that senescence of cells within joint tissues may play a pathological role in the causation of OA.
This suggests the possibility that narrative structure supports event understanding for older adults.
This suggests the safety of using NRT.
This suggests to analyze demographic and socio-cultural aspects of region and besides analyzing the consumption and metabolic markers related to food.
This suggests tolerance for lower thyroid hormone levels in this age group.
This suggest that telomere shortening does not antedate depression and is not an intrinsic feature.
This suite of lesions would have postural consequences and was most likely painful.
This superior vector more accurately reverses the forces of aging displayed on the ptotic midface.
This supports including a measure of proverb interpretation to the assessment of older adults.
This supports the concept that age-related labrum pathology may result from tissue degeneration.
This supports the hypothesis of a behavioural pathway in the self-perceptions of ageing health link.
This supports the hypothesis that autologous ADSC from aged subjects might have an impaired therapeutic potential.
This supports the hypothesis that hip extension ROM and plantar flexor strength are limiting factors in gait and contribute to age-related differences in gait.
This supports the idea that SNHL affects TFS processing independently to age.
This supports the inverted-U-shaped model of neurotransmitter action.
This supports the need for further molecular and clinical studies to determine the factors regulating IGFBP2 expression and its relevance to metabolic diseases.
This surgical technique is simple , easily reproducible.
This survey did not employ any oral examinations.
This switch increases adipocyte numbers and decreases the number of osteoblasts , contributing to age-related bone loss.
This switch is not yet fulfilled at school age due to immature executive functions.
This switch may hold significant implications not just for metastasis , but also for therapy resistance.
This symposium reviewed design parameters that are necessary to develop comprehensive national databases on healthy aging.
This symposium stimulated extensive discussions on science and potential collaboration among the @number@ participants.
This symposium was organized to discuss marginal donors and high risk recipients.
This syndrome determines a change in the functional abilities.
This syndrome has been the subject of intense promotional activity that has presented the phenomenon as highly prevalent and with a major public health impact.
This syndrome is associated with hypertension , cardiovascular disease , cognitive impairment and metabolic abnormalities , such as type @number@ diabetes.
This syndrome is caused by heterozygous de novo mutations in the POLD1 gene.
This syndrome presents alterations in many organs and systems such as the skin and the skeletal and cardiovascular systems.
This synergy between aging and heart failure could further disrupt cell energy and redox homeostasis and contribute to exercise intolerance in this patient population.
This Synthesis highlights a series of recent studies that has systematically interrogated age-related deficits in cold-induced skin vasoconstriction.
This system acts against face aging and all four elevation structures form what the so-called sustentaculum facies.
This system allows continuous real-time measurement of skin impedance delivering constant energy to the patient skin independent of changes in its impedance.
This systematic literature review aims to explore the etiology of photoaging and address the evidence behind its current management.
This systematic review aimed to determine whether this ageing paradox is demonstrated when the Frailty Index ( FI ) is used to measure frailty.
This systematic review aimed to evaluate the effectiveness of interventions led by hospital or community pharmacists in reducing unplanned hospital admissions for older people.
This systematic review aimed to investigate the prevalence of chronic musculoskeletal disorders in elderly Brazilians.
This systematic review aims to establish which cognitive domains are associated with falls or falls risk.
This systematic review aims to investigate the relation between somatic comorbidity burden and progression in late-onset Alzheimer's disease ( LOAD ) .
This systematic review and meta-analysis were carried out to compare nutritional benefits of enteral feeding versus oral feeding in long-term care facilities.
This systematic review critically evaluates the evidence for the effectiveness or efficacy of botanical treatments in reducing skin aging and wrinkling.
This systematic review evaluates the benefits and harms of antihypertensive agents in adults aged ≥65 years.
This systematic review evaluates whether recruitment efficiency and rates have increased in acute stroke trials from @number@ to @number@
This systematic review examined evidence about the effect of self-management interventions that target both general medical and psychiatric illnesses and evaluated the potential for implementation.
This systematic review examines the relationship between late-life spousal bereavement and changes in routine health behaviors.
This systematic review focuses on the use and value of CGA in ED for evaluation of older patients and its influence on adverse outcomes.
This systematic review identified existing QIs for community care for older people and assessed their methodological quality.
This systematic review investigates the diagnostic test accuracy ( DTA ) of simple instruments for identifying frailty in community-dwelling older people.
This systematic review summarizes the literature concerning the effects of physical activity and exercise on P300 in the elderly.
This systematic review summarizes the psychometric properties of goal-setting instruments that are applied within geriatric rehabilitation.
This systematic review synthesizes the research on screening and assessment tools used to determine older adults ' fitness to drive.
This system can be used to evaluate the anti-aging potential of test agents by assessing attenuation of maximal senescence.
This systemic pharmacological intervention in old-aged animals limits glomerulosclerosis and senescence , reduces parietal epithelial cell activation , and improves podocyte and endothelial cell integrity.
This system induces a more balanced Th1- and Th2-type cytokine response which supports both mucosal SIgA and systemic IgG1 and IgG2a Ab responses.
This system maintains protein homeostasis and is essential for life.
This system might be used to stratify individuals for CRC screening.
This task is far from trivial , and can be prohibitive for non-bioinformaticians.
This task was performed in quiet , as well as , @number@ @number@ @number@ and @number@ dB SNR with two-talker speech competition.
This task was repeated ten times under two temporal conditions ( self-initiated [ SI ] vs. reaction-time [ RT ] ) .
This task with increased validity might contribute to the differentiation with Alzheimer's disease by improving specificity of assessment.
This taxonomy might be useful in pinpointing the focus of future investigations and clarifying dimensions specific to social participation.
This technique allows a good bony fixation with a low rate of complications.
This technique allows for sharing data electronically with ease.
This technique allows us to identify when , where and how bran works.
This technique can also be used to examine proteopathies that are associated with human disorders such as frontotemporal dementia , Huntington and Alzheimer disease.
This technique can be useful in patients requiring a distal revascularization associated with a cutaneous cover.
This technique has also been gradually accepted as one of the palliative treatment options in patients with cutaneous tumors with risk factors for surgery.
This technique has several advantages including securing the airway first for an anticipated difficult IV placement.
This technique is almost labour free without the need for sample preparation.
This technique is not considered to fix the joint permanently if the screws are removed.
This technique makes hyalurostructure a competent and promising treatment for tear trough management.
This technique nearly always employs mass spectrometry as the major platform to achieve the goals of identifying the target proteins.
This technique offers a natural and long-lasting effect.
This technique offers another refinement in the evolution of medial thigh contouring.
This technique offers the same advantages of hand assisted videolaparoscopic technique , no disadvantages , and no major complications.
This technique provides a promising alternative to surgery by promoting safe and natural healing.
This technique , though acceptable , needs additional precautions in inexperience older adults to prevent injury.
This technology has grown at an exponential rate over the past few years , culminating in the Nobel Prize in medicine.
This technology is advantageous for tracking effects of biological aging and predicting adverse outcomes when compared to the traditional use of specific molecular biomarkers.
This technology is based on the principles of anhydrobiosis and thus permits room-temperature storage of DNA.
This tendency did not disappear in an unadjusted model.
This term and women's opinions of it can be viewed as exemplary of two competing ideologies about aging and sexuality.
This test has been shown to predict fall risk , but the biomechanics of this test are not fully understood.
This test of letter-writing ability and cognitive performance was administered over @number@ days.
This test will allow researchers to gain insight into the early emergence of divergent thinking.
This text reviews some recent published articles about the role of OS in ND.
This theme concerned participants ' low treatment expectations from their family members due to their perception of their family members as having multiple obligations.
This theme referred to the perception of the migrant home care workers and nursing staff as essential.
This theme should target a broad audience ranging from ENT clinicians to scientists , including pharmacologists and pharmacists.
This theme was focused on the participants ' perceptions of themselves as helpless and dependent on others.
This theory describes the factors critical to ' finding home ' in long-term care settings.
This theory provides a compelling explanation for the occurrence of hypogonadotropic hypogonadism in patients with inactivating mutations in the TAC3 or TACR3 genes.
This theory rose to prominence in the 1990s as the dominant theory for why we age and die.
This theory states that an accumulation of damage to the mitochondria may underlie the process of aging.
This therapeutic care must be multidisciplinary as physical rehabilitation ; orthotics and technical aids are all essential.
This therapeutic intervention is independent of the MTO1-mediated tRNA modification and involves balancing of mitochondrial and cellular secondary stress responses.
This therapeutic void in part reflects an incomplete understanding of the biochemical pathogenesis of this disease.
This therapy involves the use of a patient controller for home-use.
This therapy is primary prevention of cardiovascular diseases and osteoporosis , depression , Alzheimer's and Parkinson's disease and urogenital atrophy.
This therefore provides a controversial paradigm in which reduced regenerative capacity of skeletal muscle tissue with age potentially promotes longevity of the organism.
This time stamping requires the engagement of mAChRs.
This tissue damage is linked to cerebrovascular dysfunction and is associated with cognitive decline.
This , together with the observed reduction in minor-allele carriers among centenarians , points to a detrimental role for the SNP.
This tolerance was associated with a better clinical efficacy of PEG @number@ compared to lactulose.
This took the form of older adults having poorer report accuracy at any given loudness level for sentences with greater syntactic complexity.
This tool classified @percent@ of the patients as frail with a sensitivity of @percent@ and a specificity of @percent@.
This tool could also be used to evaluate the risk several times during the revalidation procedure.
This tool could improve the accuracy of outcome measures for occupational therapy interventions.
This toolkit consists of a C + + program and a series of Python and R scripts.
This tool provides a solution for achieving normalization-based measurements with increased accuracy , while reporting scientific findings in a consistent framework.
This topic is currently not fully understood and further research is warranted.
This topic is of global significance due to the wide distribution of food fortification programs , so prospective studies should be a high priority.
This tracking and balance task is made progressively more difficult by increasing the disk's overall excursion amplitude.
This trade-off is likely caused by the lipid-metabolism-related ( for CVD ) and nonrelated ( for cancer ) mechanisms.
This traditional herb has been documented for centuries to treat various diseases such as depression , allergies , inflammation and asthma.
This training-effect may play a key role to preserve diastolic filling in older athletes.
This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct.
This trajectory is coincident with a decrease in the content of the mitochondrial respiratory chain complex I-IV.
This transient congression is further perturbed by co-depletion of Kid , suggesting its role in chromosome congression.
This translates into more persons with disabilities and the need for more Physical and Rehabilitation Medicine ( PRM ) services.
This translocation causes the expression of a deregulated BCR / ABL fusion oncogene and , interestingly , is detectable in healthy individuals.
This transmembrane glycoprotein is involved in amino acid transport , modulation of integrin signaling , and cell-to-cell fusion.
This transynaptic process is repeated by olfactory neurons , thereby distributing the drug to other brain regions.
This Trauma association was driven by verbal list and prose passages learning and memory , but not recognition memory.
This treatment also enhanced in vivo acetylcholinergic activity in the frontal cortex , hippocampus , and amygdala but reduced NK3-R mRNA expression in the hippocampus.
This treatment appears to be safe and well tolerated.
This treatment increased the amount of WRN transcript and protein product by activating its promoter and telomerase promoter activity and gene expression.
This treatment may be combined with topical agents.
This trend has affected the size of families in the direction of fewer children born per couple.
This trend , if confirmed in community-based studies , may lead to new insights in our understanding of both normal and pathologic brain aging.
This trend is also found in other countries worldwide.
This trend is a natural response of specialists to the evolving needs of their patients.
This trend is expected to continue as many governments will have to reduce their healthcare spending in response to the current growing budget deficits.
This trend is likely to continue in coming years.
This trend is particularly evident in Western countries , where healthier living conditions and better cures are available.
This trend places ever-growing medical and economical burden on society , as many of the older subjects suffer from age-related diseases and frailty.
This trend was also observed when data were sorted by gender.
This trend was not observed for MFBIA ( P = @number@ ) .
This trend was not observed in MDD cohort.
This trend was observed in both sexes.
This trend was observed until the sixth decade of life , though only slight changes were found.
This trend was particularly pronounced among female pediatricians and those aged @number@ to @number@ years.
This trial is registered at Clinical.gov , number NCT01496248.
This trial is registered at clinicaltrials.gov as NCT00183040.
This trial is registered at ClinicalTrials.gov , number NCT01041989.
This trial is registered at controlled-trials.com as ISRCTN41926726.
This trial is registered with Clinicaltrials.gov ( NCT01689246 ) and the European Union Clinical Trials Registry ( 2012-002866-11 ) .
This trial is registered with clinicaltrials.gov , number NCT01690988.
This trial is registered with ClinicalTrials.gov , number NCT02154126.
This trial showed that a high-dose vitamin D supplementation is not more efficient than conventional dosing in improving functionality in institutionalized elderly.
This trial underscores the burden undertaken by caregivers as they provide care for family members with Alzheimer disease and the difficulty in slowing functional decline.
This trial was registered at clinicaltrials.gov as NCT00000611.
This trial was registered at clinicaltrials.gov as NCT00080171.
This trial was registered at clinicaltrials.gov as NCT00272428.
This trial was registered at clinicaltrials.gov as NCT0036232.
This trial was registered at clinicaltrials.gov as NCT00427193.
This trial was registered at clinical trials.gov as NCT00794079.
This trial was registered at clinicaltrials.gov as NCT00891696.
This trial was registered at clinicaltrials.gov as NCT01154400.
This trial was registered at clinicaltrials.gov as NCT01231958.
This trial was registered at clinicaltrials.gov as NCT01615159.
This trial was registered at clinicaltrials.gov as NCT01847261.
This trial was registered at clinicaltrials.gov as NCT02203890.
This trial was registered at clinicaltrials.gov as NCT02371278.
This trial was registered at clinicaltrials.gov as NCT02843009.
This trial was registered at isrctn.org as ISRCTN13916953.
This trial was registered at www.controlled-trials.com as ISRCTN42776917.
This trial was registered in the Australian New Zealand Clinical Trials Registry under trial number ACTRN12616001281482 on @date@ .
This trial will also examine the cost-effectiveness and willingness to pay for TAP compared with a control group.
This turned out to be wrong.
This tutorial review is focused on some mechanistic aspects of peroxidation process and chemistry of phenolic chain-breaking antioxidants.
This twin study detected a significant genetic and environmental basis in the phenotype correlation between cognition and hearing , which differed across frequencies.
This twisting into the sacroiliac joint was incriminated in the origin of chronic low back pain.
This type of analysis is a powerful and non-invasive tool to probe anatomical changes associated with neurodevelopment , aging , disease or experience-induced plasticity.
This type of brain injury is very complex and is divided into two major components.
This type of lipid accretion was not related with ageing nor age-related sarcopenia.
This type of memory has been found to be particularly sensitive to ageing , probably because it requires a self-initiated response at a specific time.
This type of pain is often insensitive to the traditional pain pharmacopeia or surgical intervention.
This type of preliminary evaluation is crucial to infusing new practice initiatives in complex organizations caring for stigmatized , at-risk populations.
This type of service could be promoted to prevent institutionalization.
This type of stability pattern pervades the age-related diseases and suggests that intrinsic properties within populations determine these fractions.
This type of training has broad positive influence on organism.
This ubiquitous and intimate association between CL and energy-transducing membranes suggests an important role for CL in mitochondrial bioenergetic processes.
This UK-based qualitative study explored multiparous women's experiences of being \ "older \ " mothers.
This underdiagnosis results in a treatment gap.
This underlines the importance of effective risk communication by doctors to help patients make appropriate medical decisions.
This underlines the importance of measuring total testosterone in men as the predominant male sex hormone.
This underlines the importance to look beyond use versus nonuse when studying older adults ' Internet use.
This under-recruitment and over-recruitment brain activity was also present in old adults.
This underscores the importance of appropriately modeling the two endpoints when designing clinical trials.
This underscores the need for further studies and better training on this issue in health care education.
This underscores the need for more aggressive metabolic control in young-onset T2DM.
This underscores the relevance of quantitative methods to characterize the network's functional status as a way to assess the myocyte's resilience to pathological stressors.
This understanding can be used to develop resources and approaches to better support physicians in making appropriate linkages to CSSs.
This understanding means that we can act to prevent cancer by means of efficiently monitoring and maintenance of physiological hormonal values.
This unexpected APP-mediated signaling pathway may play an important role in maintaining TTR and Klotho levels and their respective functions in Aβ sequestration and aging.
This unexpected finding needs further investigation.
This unexpected observation probably reflected the highly selected nature of the study participants.
This unexpected population also appears in young lupus-prone mice.
This update assesses the impact of this additional evidence and effective revisions.
This update presents the main findings of research within the GAZEL Cohort Study during the past @number@ years.
This use was higher in females than in males and decreased in older age groups in both sexes.
This U-shaped association between CES-D and obesity status was confirmed by a model in which CES-D scores were regressed on BMI scores and other covariates.
This U-shape like trend was also present when aortic root sections were examined histologically.
This US study did not suggest any effect of staffing levels on dehydration prevalence.
This vaccines had high cost-benefits.
This validated age-related AMH nomogram will enable counseling of infertility patients regarding reproductive performance.
This variability can have implications on drug absorption and bioavailability.
This variability could not be satisfactorily explained solely by the neuronal effects.
This variable was then used to quantify the developing teeth , all together , through the use of the additive conjoint measurement method.
This variant alone explained @percent@ of the variation in fetuin-A levels.
This variant may be primarily restricted to Icelandic and Scandinavian populations.
This variant probably impacts the interaction between GRM4 and miR-1202.
This variant strictly cosegregated with the disease phenotype and was absent in online single-nucleotide polymorphism databases and in @number@ additional exomes of control participants.
This variation was partially explained by differences in goal orientation.
This verifies our hypothesis that a plantar impulse can function as a means to assess and evaluate musculoskeletal system injuries and aging.
This version showed good psychometric properties.
This version was then applied to @number@ participants with Alzheimer disease.
This view is supported by observational studies as well as by small-scale clinical trials.
This viewpoint implicates the brain's support system and its disruption by various age and disease-related insults as significant mediators of neurodegenerative disease.
This viewpoint separates the modulation of aging from the treatment of one or more age-related diseases.
This view was also shared by healthcare professionals.
This visual rating scale may facilitate the differential diagnosis of FTLD in clinical routine.
This volume examines modifiable risk factors for periodontitis and other chronic inflammatory diseases.
This volume loss can be compensated by microfattransfer.
This vulnerability is not only age-related , but also related to disability and comorbidity , as illustrated by three clinical cases.
This warning effect was not observed in the older participant group analyses but was found for three participants based on individual data analyses.
This was a 24-h intensive PK study.
This was a 5-year follow-up survey of @number@ community-dwelling Japanese individuals aged ≥40 years.
This was a case-control study with @number@ Chinese-American subjects and @number@ demographically and cognitively matched white subjects.
This was a case study in the maintenance engineering division of a high-complexity hospital in the city of São Paulo , Brazil.
This was accompanied by an age-related reduction in type II muscle fiber satellite cell content ( r = −0.57 ; P < @number@ ) .
This was accompanied by an increase of neural activity in ACC ( p < @number@ small-volume correction for multiple comparisons ) .
This was accompanied by a significant decrease in expression of reductase , and a significant increase in expression of cholesterol 24-hydroxylase.
This was accompanied by a significant decrease in the malondialdehyde ( MDA ) level in mice given ARE compared to the control.
This was accompanied by elevated rectus femoris EMG ( from @percent@ to @percent@ , p < @number@ ) .
This was accompanied by higher glomerular endothelial cell density ( CD31 ) .
This was accompanied by reactive oxygen species production and pro-inflammatory cytokines , chemokines and proteases secretion.
This was accompanied by thickening and hyperkeratosis of hair follicle infundibula.
This was achieved by inducing in vitro and in vivo spontaneous differentiation.
This was administered to homeless-experienced clients ( n = 563 ) across @number@ VA facilities and @number@ non-VA Health Care for the Homeless Program.
This was a focused ethnography using participant observation and semi-structured interviews.
This was again more important for individuals with higher education and for older subjects ( ≥ @number@ years ) .
This was also accompanied with a decrease in force steadiness.
This was also found to be true in a Parkinson's disease model.
This was also proven by ANOVA testing when sample was divided into age groups.
This was also reflected by Kaplan-Meier survival estimates ( P for log-rank test of @number@ ) .
This was also solved by expressing K6W-Ub. p27 ( kip ) , a UPP substrate accumulates in lenses which express K6W-Ub.
This was also the case for the C5a complement receptor and CD11b.
This was also true for discrete simultaneous tapping.
This was a mixed-methods study of @number@ San Francisco police officers recruited from mandatory police trainings between @number@ and @number@
This was an Internet-based questionnaire study , which sought to determine the opinion and perception of responders on issues relating to ageing and dementia.
This was a population-based study in which a random sample of @number@ individuals of the community aged over @number@ years were interviewed using SF-36 questionnaire.
This was a post hoc single arm intervention study of participants who completed the exercise intervention ( n = 50 ) .
This was a randomized controlled trial including @number@ overweight / obese adults with type @number@ diabetes ( T2D ) and OSA.
This was a randomized control trial study.
This was a randomized , double-blind , placebo-controlled , 12-week pilot study.
This was a reflection on the efforts of primary and secon- dary prevention , initiated in the 1980s in which Geneva was a pioneer.
This was a retrospective , non-randomized observational study.
This was a retrospective study of patients @number@ years and older that were admitted to our Level I trauma center from @date@ to @date@ .
This was a split-face , evaluator-blind , randomized controlled study.
This was associated with dissatisfaction with care.
This was associated with gradual acquisition of a memory phenotype and was curtailed by DUSP4 silencing.
This was associated with higher risk of depression.
This was associated with increased activity of the repressor of hTERT transcription E2 transcription factor and decreased activation of NF-κB that promotes hTERT transcription.
This was associated with increased production of reactive oxygen species and cell death.
This was associated with increased pro-survival gene expression in cardiac tissues.
This was attenuated after transfusion of pRBCs treated with amitriptyline or from acid mice.
This was believed to be the effect of the aging population rate continuing to increase each year in Akita City.
This was concomitant with an increased expression of matrix-metalloproteinase ( MMP ) -9 and plasminogen activator inhibitor ( PAI ) -1.
This was confirmed by PCR at the species level for Fusobacterium nucleatum.
This was considered to be valid since brain MAO and iron increase in PD and aging , which could lead to oxidative stress-dependent neurodegeneration.
This was consistent with a promoting role for HSP70 in ROS-associated neutrophils response to pathogens.
This was coupled with a tendency to show greater recruitment of frontal regions , and underactivation of extrastriate visual regions.
This was demonstrated using cohort data taken for the entire lifespan as well as for only old ages.
This was despite objective deterioration in functional status , paralleling the aging process , and high dependence on others for everyday tasks.
This was despite the fact that , after rewarded trials , reach variability in the patients was comparable to healthy controls.
This was done by calculating the percentage change in Btime after adding the particular factor to the model.
This was done regardless of their actual accuracy , and the questions were then repeated.
This was done showing fluctuations in the magnitude of this covariation within a sample of modern human mandibles at different postnatal ages.
This was done using a battery consisting of seven previously validated cognitive function tests assessing both global function and specific domains.
This was especially true in terms of understanding the disparate roles of the individuals involved in implementing and facilitating the recruitment plan.
This was even the case in a mildly undersized THV when compared with the internal diameter of the surgical bioprosthesis.
This was evident using objective measures of lower-light intensity , and both objective and self-reported measures of higher-light intensity activity.
This was followed by a description of the current knowledge of their neurophysiologic aspects.
This was followed by a longitudinal prospective cohort feasibility study that was conducted in three nursing homes in NI.
This was followed by a manual search for articles cited in the previously identified publications.
This was followed by a survey of the health , well-being , and life history of all consenting participants.
This was followed by substantial increases in levels of several matrix metalloproteinases and later by significant induction of type I collagen.
This was followed , in descending order , by the social , functional and familial , and demographic domains.
This was found to be regulated by the decrease in HDAC1 , DNMT1 , survivin and HDAC activity in all three cell lines.
This was further informed by Scottish prescribing statistics.
This was further supported by the lack of significant correlations between the single-trial Ne / ERN amplitude and error-related reaction times.
This was highly significant for biochemical losses but not for fetal heart miscarriages.
This was identified and subsequently revised with a revision prosthesis.
This was independent of other cardiovascular risk factors and APOE ε4 carriership.
This was in line with moderate 11C-PBB3 versus faint 18F-AV-1451 autoradiographic labelling of these tissues.
This was in particular detected in female patients.
This was intended to enhance the quality of life ( QoL ) of people with dementia and to reduce the burden on their informal caregivers.
This was investigated in this study.
This was linked with increased perceived personal responsibility for quitting.
This was measured using a motivation questionnaire that included expectancy and value subscales.
This was monitored by its ability to prevent the modification of intact Trp residues in HGC ( c ) isolated from cataractous human eye lens.
This was more pronounced in the ankle joint.
This was most evident in planned somatic in- and outpatient care.
This was most pronounced for care-seeking.
This was not accompanied by significant changes in the endothelial expression of TJ proteins.
This was not associated with gross pancreatic pathology.
This was not because the dominant arm was stronger.
This was not seen in cancer cells , except in a benign senescent tumor in vivo.
This was not seen in infected siblings birthed into room air.
This was not seen with fresher RBCs.
This was not the case.
This was not the case for any of the other CSF markers examined.
This was parallel to enhanced lysyl oxidase-like ( LOXL ) @number@ and @number@ expression.
This was particularly evident in patients with major genetic and atherosclerotic risk factors.
This was partly rescued with the DPP-4 inhibitor sitagliptin , but not with glucagon administration.
This was performed with or without synchronizing to the sounds.
This was seen after a period of chronically elevated levels of allopregnanolone , but not after placebo treatment.
This was shown in the NAWM , WMH , and CGM , supporting the generalized nature of cSVD.
This was shown with objective numerical grading and through observer assessment.
This was significant assuming an additive model for gene-dosage association ( univariate analyses : p = 0.032 ) .
This was significant in Group @number@ with no VDD-M0 ( P = 0.039 ) , but not in Group @number@ who already had VDD-M0.
This was similar to the intrinsic aging ability of our best field observer ( @percent@ ) .
This was statistically significant with pre-op IIEF-15 = 30.52 and post-op @number@ ( p < 0.05 ) .
This was substantiated by a representative sample of US Medicare beneficiaries using self-reported visual function , reinforcing the value of identifying patients with visual compromise.
This was supplemented with a manual search of selected journals and textbooks.
This was supported by qualitative comments from the adults who reported that the PSVS was the most difficult straw to use.
This was supported by the pathway analysis of metabolomics data , which identified upregulation of pentose phosphate pathway in patients who later progressed to AD.
This was surprising , as mTORC1 is generally perceived as an inhibitor of autophagy.
This was surprising , given the rapid aging of the U.S. population , a population that is living longer with multiple chronic conditions.
This was tested in the context of semantic relations between task-relevant word pairs , a task-irrelevant picture and the resultant N400 differences in ERP.
This was the first human AUD brain iron study and the first retrospective clinical fMRI QSM study.
This was then systematically operationalized into a program using discussion groups and consensus among experts and stakeholders.
This was true for IgM as well as IgG isotype responses.
This was true for young and high performing older adults only.
This was true in each group.
This was used as the reference standard to measure diagnostic test accuracy value.
This wavelength possesses a higher absorption coefficient for water than the @number@ , 550-nm , conferring greater ability to target epidermal processes.
This way , autophagy contributes to the homeodynamic turnover of proteins , lipids , nucleic acids , glycogen , and even whole organelles.
This weight differential is predominantly due to increased deposition of FM in girls and FFM in boys.
This weight loss was suppressed in IL-13-deficient ( knockout ; KO ) Tg mice.
This wide range of evidence implies that dietary hyperglycemia is etiologically related to human aging and diseases , including DR and AMD.
This will allow a more scientific approach to method development for fingermark enhancement techniques.
This will also provide the foundation for interventional research programs towards preservation of brain health and behavioral performance by maximizing neuroplasticity potential in older adults.
This will assist emergency physicians ( EPs ) in risk stratification.
This will assist emergency physicians in risk stratification.
This will be accompanied by an increase in age-related conditions that will strongly impair human health and quality of life.
This will be impossible without a substantial increase in academicians engaged in education and aging research.
This will be possible once a better understanding is gained of the molecular basis explaining the impact of phytochemicals on human health.
This will contribute to the development of more effective interventions for frail elderly.
This will contribute to theory building as well as assist in identifying the causes and consequences of security.
This will have important implications for health.
This will help guide the future development of targeted therapeutic agents.
This will help to relate and interpret other structural , functional , and behavioral measurements , both from healthy subjects and pediatric patients.
This will inform health policies and identify locally acceptable strategies to promote healthy aging , prevent and delay functional decline among older Malaysian adults.
This will inform the development of targeted strategies to address the lack of service use among these family caregivers.
This will place an increasing economic and clinical strain on healthcare systems.
This will result in a healthy and youthful appearance creating a facial V-shape.
This will result in a surge of CEA's !
This will ultimately help designing more efficient and comprehensive physical activity guidelines for older adults.
This will verify the extent to which adversity impacts upon the biological development of cell aging in childhood.
This work adds to the literature suggesting that exploitation of retrospective prostate tissue collections with robust associated clinical data is possible.
This work aimed to analyze quantitative changes of peritubular cells in testes of aged men.
This work aims to extend our findings to European and Asian populations.
This work aims to investigate the anticancer properties of Allium atroviolaceum and the mechanism of action.
This work aims to produce a set of HarP labels for the proper training and certification of tracers and algorithms.
This work also contributes to a better understanding of the factors influencing patient-specific radiation dose calculation.
This work anticipates development and application of ethical standards suited to dynamic advances in aging research.
This work demonstrates the development of a significant AD-like neuropathology due to these metabolic alterations.
This work employs another marker of cognitive flexibility and extends our work to older adults.
This work examined the aging-related effects of temporal pressure on movement synchronization and dynamic stability.
This work highlights the capacity for local genetic variation in mosquito populations to evolve and to dramatically affect the nature of human outbreaks.
This work highlights the need for combined quantitative histological MRI studies.
This work identifies age-related methylation in normal breast tissue and begins to deconstruct the contribution of aging to epigenetic alterations present in breast tumors.
This work indicates a regulatory role of ERβ in transcription and cognition , which depends on estradiol levels and the function of ERα.
This work indicates that multimodal integration can improve the ability of distinguishing differences between groups and might be assisting in further diagnosis of schizophrenia.
This work indicates that OMS can improve body balance and that SCR allows the objective evaluation of the consequences of OMS.
This work investigates an approach to assess IM based on the Oldenburg Sentence Test ( OLSa ) .
This work is an attempt to systematize the existing knowledge about the p66Shc protein structure and functions.
This work is an essential preliminary step towards developing research involving indigenous communities , drawing on the social participation of elders and intergenerational solidarity.
This work is potentially relevant to the aging population given that age-related immune defects , including chronic inflammation , coincide with declining zinc status.
This work might shed light on the physical reason behind the irreversible deformation of echinocytes , acanthocytes and malaria infected red blood cells.
This work presents a novel application of Sugihara causality analysis to capture characteristic changes in EEG activity due to cognitive deficits.
This work presents a novel consumer correlated quantitative linear model of skin brightness by which to communicate age-related changes.
This work provides a background upon which to base initiatives to help these higher-needs clients manage their HF at home with appropriate support and services.
This work provides a useful basis for subsequent studies on aging and age prediction.
This work provides important insights into ways in which epigenetic changes can alter gene expression and thereby lead to human disease.
This work provides insight of the molecular mechanism underlying UV-induced photoageing and skin cancer development.
This work reinforces the importance of routine medication reviews , especially in elderly exposed to psychotropic polypharmacy regimens that include antipsychotic drugs.
This work reports on the relative survival ratios and excess mortality rate in children with astrocytic tumors over the past four decades.
This work revealed promising candidates for future experimental validation while demonstrating the applications of powerful screening methods for this and similar endeavors.
This work summarizes the information about AMPK participation in the aging process.
This work supports a role for SHMT1-related genes and nuclear folate metabolism , including the thymidylate biosynthesis pathway , in mediating CVD risk.
This work therefore proposes novel low-cost skin aging assessment apparatus by using light back-scatter intensity level of Red , Blue , Green and Infrared bands.
This worsening of the motor performance was significantly correlated to the severity of comorbidities and to the global level of autonomy.
This would be observable as changes in the morphology of the RBCs and of PD patients relative to healthy controls.
This would contribute to a more equitable , interdependent and wiser society.
This would enable the generation of ESCs genetically identical to the somatic cell donor and their use in cell therapy.
This would help provide a competitive advantage to the best operators.
This would help to define more individual strategies for prevention and early stages of a certain defined disease.
This would make it unnecessary to use vitamin and mineral supplements.
This would support endothelial function by adequate NO production and homeostasis of endothelial function.
This would support our hypothesis that the genetic influence upon exceptional longevity increases with older and older ( and rarer ) ages.
This year's article compares the UK with other European countries and a range of nations from around the world.
This yielded confirmation of 171 / 190 , or @percent@ , of the original author-based FORTA labels.
This yielded @number@ collocates that were rated for negativity and medicalization.
This younger group , which contained few age-related lesions , also demonstrated that subcortical lesions on FLAIR are more specific for TBI than deeper lesions.
Thoracic anesthesia for elderly patients requires greater specific knowledge.
Thoracic kyphosis angle , lumbar lordosis angle , thoracic ROM , lumbar ROM and spinal inclination angle were measured using SpinalMouse ( ® ) .
Thoracic manifestations include parenchymal , bronchiectatic , and endobronchial actinomycosis.
Thoracolumbar curvatures ( thoracic and lumbar ) were measured using a motion tracker.
Thoracoscopy was performed and revealed multiple sizes of nodules on the visceral and parietal pleura.
Thorotrast is known to induce liver tumors , particularly intrahepatic cholangiocarcinoma ( ICC ) and angiosarcoma ( AS ) , decades after injection.
Thorough clinical assessment and early use of MRI scanning will assist physicians with a more accurate diagnosis of older adults with this kind of presentation.
Thorough evaluation for existence of diseases such as normal pressure hydrocephalus and vascular parkinsonism which partially mimic the symptoms of PD carries immense importance.
Thorough testing of aging methods is therefore of key importance.
Those aged @number@ and over and children under @number@ will be significant drivers of GMS costs with the impending demographic changes.
Those aging with disability may be especially at risk for pain-related impairment in later life.
Those anatomic structures that play a role in this process are examined here.
Those are conditions under which APC models should never be used.
Those are the subjects which will one day provide an experimental evidence of the efficacy of melatonin.
Those assigned to a control group completed only the first and last training task.
Those associated with T-cell functions were less abundant.
Those \ "At-Risk \ " experienced more collisions with oncoming cars and had longer crossing times in the Phone condition compared to controls.
Those at the top of the childhood SEP distribution had between @percent@ and @percent@ better performance than those at the bottom.
Those baby boomers who are the most vulnerable at the end of their working lives are more likely to become vulnerable during retirement.
Those changes were related to changes in well-being with partial support for a lead-lag relationship.
Those concerned about burdening a caregiver wanted to make independent decisions.
Those containing phrases pertaining to psychological , emotional , behavioral or social adjustment in the title , abstract or keywords were selected.
Those demonstrating a stronger implicit anti-black bias and reporting higher levels of racial discrimination had the shortest LTL.
Those drugs transiently normalize tumor vessels and ultimately provoke vascular regression.
Those effects were assessed by semi-quantitative PCR , Western blotting and enzymic activity assays.
Those effects were similar between age groups.
Those estimates enable to classify geroprotectors as weak , moderate and strong.
Those exhibiting a greater than @number@ change in V-RQOL after treatment were significantly more likely to report swallowing symptoms pretreatment.
Those factors cause the degeneration of brain tissue which leads to significant cognitive dysfunction.
Those findings advocate implementation of dance therapy programs in older women.
Those findings may help to mitigate the risk of long QT syndrome in elderly patients in clinical practice.
Those findings might help to develop new classes of drugs which may supplement or replace classical anticoagulants and help clinicians to tackle CVD more efficiently.
Those immune responses lead to the development of memory B cells and plasma cells that secrete high amounts of antibody molecules.
Those in advancing age are vulnerable to cognitive decline.
Those in the GrCl group received @number@ months of training with a classical rehabilitation protocol that included isotonic training for the lower limbs and spine.
Those in the highest tertile of energy-adjusted added sugar intake had the highest BAP.
Those in the highest tertile of VAT had @number@.1-fold higher odds of death ( @percent@ CI @number@.1-4.0 ) compared with the lowest VAT tertile.
Those in the home care group required more assistance to attend and continue in the program than those in the general community.
Those in the incremental condition outperformed those in the entity condition on reading span and free-recall tasks.
Those in the low protein group had higher body fat and fat-to-lean ratio than those who consumed the higher protein diet.
Those in Wave @number@ were refined to improve quality , and ensure consistency for longitudinal analysis.
Those less educated , and those with income equal or less than two minimum wages had more disability , pain catastrophizing and worse functional capacity.
Those less solicited muscles were left untreated or received lower doses , allowing for more effective and natural results.
Those newly living alone also had a higher night time cortisol and flatter diurnal slope than those living with others.
Those OA taking combinations of various medications and herbal supplements are also more at risk to experience some sort of herb-drug interactions.
Those of us who survive the journey are a year older : we have aged one solar year.
Those parameters are using a quantitative method to evaluate body aging.
Those patients had moderate risk score ( @number@ ± @number@ ) in the Autar DVTRAS.
Those proteins may offer targets for the specific treatment of age-related effects on dementia severity and conversion risk.
Those providing palliative care are significantly more likely to provide non-clinic-based services such as care in nursing homes , home visits , and hospice.
Those randomised to the intervention arm will receive sessions with a trained Physical Activity Facilitator , delivering an intervention based on self-determination theory.
Those receiving care at nonteaching , for-profit , and smaller-sized hospitals were more likely to have a follow-up visit.
Those remaining life expectancies change over time and differ from place to place.
Those reporting higher mobility difficulty tended to be older , female , less educated , not married , and smokers.
Those reporting symptoms were examined clinically and @number@ had first-onset TMD.
Those responsible for the revision of the DSM-5 should ensure that the concept ' late-onset personality disorders ' is incorporated in the text.
Those results show clearly that energy requirements are not covered in acute hospitalized elderly people.
Those single reported poorer health and fewer resources than legally married and unmarried partnered.
Those stunted in childhood as well as those stunted in infancy and childhood scored significantly lower on both assessments than children who were not stunted.
Those subjected to prior authorization or step therapy were more likely to change in a subset of classes.
Those targeting fallers should consider addressing self-efficacy for overcoming neighborhood barriers.
Those targets are primarily involved in transcription , proteolysis , cellular bioenergetics , and apoptosis and regulated by TP53 and MTOR signaling.
Those using the scales should receive specific direction concerning cues to be assessed.
Those very overweight most of life and persons with dementia have the greatest disability risk and relatively long disability durations.
Those were always composed of both AβpN3 and AβN1.
Those which occur earlier , sometimes even in prenatal period , have the most serious , almost always lethal course.
Those who are frail have higher mortality , worse health outcomes , and use more health care services than those who are not frail.
Those who are married spend less on daily supplies and formal care than the unmarried do.
Those who attended any kind of training course implemented domiciliary dental care significantly more often.
Those who cannot pay medical expenses are the least likely to survive.
Those who could afford only the cheapest food or clothes were considered the group of self-reported poverty.
Those who did not thought that drinking was not a problem for them.
Those who did were commonly given restrictions not supported by evidence or guidelines.
Those who eat less , however , possibly reflecting declining health , are at higher risk of becoming depressed.
Those who engaged in little SOC talk had low well-being despite higher physical function.
Those who had been neglected had significantly more frequent depressive symptoms than caregivers who did not report neglect.
Those who had carried out high-lethality suicide attempts were more willing to delay future rewards , compared with low-lethality attempters.
Those who had LSC but had no DM , had a similar survival trend to those who had DM only.
Those who have suffered a concussion , otherwise known as a mild traumatic brain injury ( mTBI ) , often complain of lingering memory problems.
Those who lost a child used services less than other bereaved.
Those who maintain an optimal memory into the 8th and 9th decades may have lower levels of AD pathology.
Those who perceive themselves as having high levels of financial knowledge are less predisposed to feel underprepared.
Those who received disability performed worse on tasks of executive functioning.
Those who reported difficulty had significantly lower scores for dynamic balance , balance confidence and fall efficacy compared to those who did not.
Those whose HBsAg was positive were then tested HBeAg and anti-HBe.
Those who slept in the sitting posture had more frequent SDB-RSs than did those who slept with the leaning forward posture.
Those who were at risk were facing significantly more wet-type OAB ( p = 0.003 ) and nocturia ( p = 0.023 ) .
Those who were within @percent@ or increased relative to their initial AEE measurement were categorized as having preserved AEE.
Those willing to volunteer for these trials could be socially active , in relatively good health , and have high educational levels and cognitive function.
Those with a decrease in MMSE of @number@ or more points between BL and 2y-FU were considered as \ "decliners. \ "
Those with ADL limitations were asked about the perceived cause / s of their limitation / s.
Those with a high BMI had slower gait speed than those with WMH ( p = @number@ ) .
Those with a higher cardiorespiratory fitness had fewer chronic conditions and a lower BMI.
Those with anemia were more likely to perceive that they had anemia ( @percent@ vs. @percent@ , p < @number@ ) .
Those with a Type I deletion showed higher total DBC-A scores than persons with a Type II deletion.
Those with bvFTD laughed less relative to their own speech comparedwith healthy controls.
Those with cognitive impairment often have gait impairments and more falls than cognitively healthy older adults.
Those with complete SCREEN II forms were included in the study ( n = @number@ ) .
Those with confirmed diagnosis of dementia were excluded.
Those with dementia were also more likely to have OH than those with normal cognitive status ( p = 0.007 ) .
Those with depression were referred to local polyclinics.
Those with diabetes had higher Ca concentration and lower Mg concentration.
Those with difficulties were asked whether they received help or used assistive devices.
Those with DS and evidence of dementia have lower DHEA concentrations than those with DS ( controlling for age ) but without dementia.
Those with greater financial resources reported better subjective well-being with evidence of a \ "dose-response \ " effect.
Those with greater wealth were @number@ times more likely to be persistently active.
Those with GWEP roles attributed their current standing to experience gained through GACA funding.
Those with higher levels of filial satisfaction and more favorable perceptions of neighborhood safety were likely to have positive ratings of SRMH.
Those with higher mobility impairment are more likely to report lower life satisfaction partly because they usually participate less in social activities.
Those with higher psychological morbidity had poorer neutrophil phagocytosis.
Those with high levels of psychosocial maturity , regardless of subjective age , were least likely to exhibit depressive symptoms.
Those with high values of spherical error had high values of cylindrical error , as well.
Those with high WTL did not show a decrease in life satisfaction as death approached.
Those with Isolated network types will likely need to access a high volume of community-based services as they age as they lack informal support resources.
Those with low BST in conjunction with performing less than 30min / d of MVPA had lower physical function.
Those with lower subbasal nerve density , in particular , are at a higher risk for endothelial cell loss over time.
Those with more severe heart disease were more likely to be unemployed and to receive disability benefits , but educational attainment did not differ.
Those with nfvPPA laughed more in the partner context compared with healthy controls.
Those with OH had a median ( IQR ) age of @number@ ( 71-83 ) years.
Those without prevalent cardiovascular disease were followed until their first CHF event , death , last follow-up date , or @date@ .
Those with overactive bladder often experience related physical and psychological symptoms or conditions and report a poorer quality of life than other women.
Those with septic arthritis of the knee presented with swelling , pain and immobility.
Those with serious health problems have more limitations , sacrificing other aspects of wellbeing for physical health.
Those with severe cognitive dysfunction were excluded ( n = @number@ ) .
Those with shorter telomeres and these characteristics were not significantly different from those with longer telomeres.
Those with task modifications formed the middle group.
Those with vasovagal syncope ( n = @number@ ) had a median ( IQR ) age of @number@ ( 19-44 ) years.
Those women meeting the recommended Mg intake appear to be at a lower risk for fractures.
Though allopathic medicines provide fast relief , long time consumption cause serious health concerns such as hyperallergic reactions , liver damage , etc.
Though a variety of age-related alterations are observed in the structure and function throughout the brain , certain regions show selective vulnerability.
Though average performance declines with age , there is large individual variability across different cognitive domains.
Though a widely utilized term and clinical concept , ovarian reserve ( OR ) has been only inadequately defined.
Though comprehensively identifying ' driver ' mutations remains a challenge , a number of novel driver mutations in AML have been identified through whole-genome sequencing.
Though diabetes type @number@ has been proven preventable , no screening for prediabetes has been implemented.
Though frailty status has recently been linked to poorer quality of life , the impact of income on this relationship has not previously been investigated.
Though fundamental components of worldview remain remarkably stable , the expression of these elements is modified as individuals grow older.
Though heart rate differences were found among age categories and difficulty levels , none were found between participants with ADHD and controls.
Though imaging findings are well described on CT and radiographs , recognition on MRI can be challenging.
Though many stakeholders were ready to engage in teen pregnancy prevention efforts , they required additional information and training to appropriately address the issue.
Though menopause has been thought to increase CVD risk in women , the association between menopause and age obfuscates a causal relationship.
Though pigmentary changes occurred , there have been no reports of keloid development.
Though plans to eliminate malaria from the island of Hispaniola have recently received much attention , arbovirus surveillance continues to be largely neglected in Haiti.
Though poorly defined , ER-endolysosomal contact sites are quickly becoming recognized as centers for inter-organelle lipid exchange and metabolic decision-making.
Though pulmonary manifestations are predominant , ocular sarcoidosis ( OS ) affects 25-50% of patients with sarcoidosis and can lead to blindness.
Though still limited , the options to actively participate in their own deaths are growing.
Thoughtful patient-provider discussions regarding the uncertain benefit and potential decrement in QOL associated with statin continuation in this setting are warranted.
Though the cortical contributions to age-related declines in motor and cognitive performance are well-known , the potential contributions of the cerebellum are less clear.
Though the general picture of glycation has been identified , the detailed knowledge of which collagen amino acids are involved in AGEs is still missing.
Though the ISEL has been well-studied , no identified research has examined its psychometric properties or performance in older adults with CG.
Though the length of hospital stay was reduced , it remained significantly higher than the average stay.
Though the procedure is rapidly increasing in popularity , limited data is available regarding its use in deformity surgery.
Though there was a significant improvement , the scores at @number@ year were significantly lower than the pre-injury score for both groups.
Though this model is based on several sound neurophysiological observations , there are major problems as well.
Thought suppression was a significant predictor for switch costs.
Though vaccination coverage rates were high in high-risk groups ; disparities in coverage rates were substantial ; particularly in young adults.
Thousands of CpG sites whose tissue-specific methylation levels are strongly correlated with chronological age have been previously identified.
Thousands of muscle precursor cells are needed to accomplish regeneration following acute injury.
Thousands of replicated loci for common traits are helpful in diseases risk assessment.
THP-1 cell proliferation is slightly increased by αT , whereas it is inhibited by αTP.
Threats to spine survival are reduced by physical and mental activity , and declining sensory input , conditions characteristic for aging.
Three 6-second clips indicative of mild , moderate , and severe pain intensities were selected for study for each participant.
Three additional nonsense or missense mutations and a de novo microdeletion encompassing STX1B were then identified in @number@ familial or sporadic cases.
Three additional points are then made.
Three age groups were selected in both genders , namely , subjects aged 20-35 , 50-60 , and 60-70 years.
Three age-related groups were studied : newborns ( @number@ days-1 year ) , children ( 6-17 years ) and adults ( 34-60 years ) .
Three aggregated mixed methods syntheses were developed : @number@ ) Mealtimes should be viewed as high priority.
Three allometric models were used to explore the impact of allometric exponents on the total clearance of remifentanil.
Three ApoE measures were considered : ε2 , ε4 carriers versus noncarriers , and a three-category ApoE measure.
Three apparently sporadic patients were found to carry c.100C > T ( p.Pro34Ser ) heterozygous variant in the exon @number@ of CHCHD10.
Three approaches , including calculation from regression graph , multiple linear regression , and neural networks , were employed.
Three assessment methods were applied.
Three cadaveric specimens were obtained , and the L3 vertebrae were excised.
Three case scenarios ( SRM in a healthy 55-year-old , healthy 75-year-old , and comorbid 75-year-old patient ) were presented for management.
Three cases each were assigned to five age groups ( foetus , adolescent , adult , elderly , aged ) .
Three categories of utilization were created : low , moderate , and high.
Three characteristic features of tactile perception that could reflect the perceptual dimensions of the fineness , roughness and slipperiness of hair were extracted.
Three cognitive dimensions were identified : general cognition ( MMSE ) , memory ( MEM ) and executive ( EXEC ) function.
Three cognitive domains were assessed : verbal memory ( delayed recall ) , working memory / attention , and processing speed.
Three cognitive lifestyle variables were assessed : education , mid-life occupation , and late-life social engagement.
Three cognitive tests were administered in 1990-1992 , 1996-1998 , and @number@ and a full neuropsychological battery was administered in @number@
Three community-based participatory stroke promotion interventions proved partially effective , but the small sample sizes might have underpowered the results.
Three components of health are identified : independent functioning , suffering from chronic diseases and psychological health.
Three components of the ST produced increases in the right middle frontal and superior frontal , and left superior frontal regions.
Three correlation / regression approaches were used to determine how well CAEPs predicted behavior.
Three countries were chosen to perform the analysis on : Australia , Japan and the United States.
Three critical age periods in the life of those interviewed were identified , namely , 15-29 , 40-49 and 60-69 years.
Three databases and one search engine were explored with two keywords ( stroke campaign and stroke promotion ) .
Three-day dietary records were taken and adjustments for energy intake made.
Three days after practice ( Day @number@ ) , subjects were tested with practiced and novel sequences to evaluate sequence-specific learning.
Three days of wrist actigraphy were used to estimate sleep patterns.
Three Delphi rounds were conducted to reach consensus on all @number@ statements.
Three DHA exposure variables were used in separate analyses ; plasma DHA , dietary DHA , and consumption of cold-water fish.
Three different barrel toastings were evaluated.
Three different counting methods - sectioned through nucleolus , through nucleus and through any part of PC body , were used to count the PC.
Three different exercises embedded in the games were used to assess upper limb , trunk and lower limb control.
Three different TFIIH coding genes are implicated in TTD : XPD , XPB and TTDA.
Three-dimensional ( 3D ) stereophotogrammetry is a reliable technique , which is used for other purposes in soft tissue analysis of the upper extremity.
Three-dimensional ( 3D ) stone labial models were made , digitized , and 3D virtual reproductions obtained.
Three-dimensional echo provides a more robust tool to analyze the mitral valve.
Three-dimensional imaging and morphometrics using 320-ADCT are powerful tools for efficiently and reliably observing and measuring the pharynx and larynx.
Three-dimensional imaging was acquired using the 3-D camera and software.
Three-dimensional kinematics of the whole body center of mass and base of support were computed.
Three-dimensional longitudinal strain decreased , whereas 3DCε increased , with aging ( P < @number@ ) , with different trends in men and women.
Three-dimensional LV volumetric images were acquired from @number@ healthy volunteers ( aged 21-82 years ) and were analyzed by a recent speckle-tracking method.
Three-dimensional mitral valve area , length , and volume parameters were linearly related to body surface area ( P < @number@ ) .
Three-dimensional reconstruction and 2-dimensional sagittal views were used to measure the distance between the mandible and hyoid bone.
Three-dimensional renderings have been obtained after aligning the serial sections , while high-resolution z-stacks have resulted after deconvolution on the thick sections.
Three-dimensional sensor information and 3-4-second window length were desirable.
Three-dimensional surface displacements were calculated during inflation testing using digital image correlation ( DIC ) .
Three-dimensional T1-weighted magnetic resonance images were obtained in @number@ LLD and @number@ matched hospital controls and processed using FreeSurfer.
Three elastograms were obtained in each case by endosonography in a defined section through the pancreatic body.
Three elements are implicated in the loss of balance : vision , proprioception and the vestibular system.
Three elements are needed for PDT : a photosensitizer , oxygen , and a light source.
Three episodes of good work are described to illustrate how social situations can be shaped.
Three equivalent fusions which influenced the men are : ' Age is claiming its due' , ' Living with uncertainty' , and ' Strengthen self-esteem'.
Three evaluations were made : during , immediately after , and @number@ minutes after treatment.
Three evaluations were made : during treatment , immediately after treatment , and @number@ minutes after treatment.
Three evaluators were randomly chosen for further statistical analysis in an attempt to make the assessment technique more practical.
Three experiments examined children's and adults ' abilities to use statistical and temporal information to distinguish between common cause and causal chain structures.
Three factor ANOVA models tested main effects ( group , muscle and reach ) and interactions for PC scores.
Three factors ( systolic blood pressure , gait-balance composite , subjective health ) were significant mediators.
Three fall-classification models were then built using Partial Least Squares-Discriminant Analysis ( PLS-DA ) , with separate and combined analyses of the fall risk factors.
Three focus groups ( N = @number@ ) were conducted in two different urban settings in the northeastern part of the United States.
Three focus groups were held with nine mental health professionals who work with SEA elders.
Three follow-up waves of data collection were used : @number@ @number@ and @number@ years.
Three genes code for different RyR isoforms and each gene transcript gives rise to several alternatively spliced messenger RNAs ( mRNAs ) .
Three genes encoding CS glycosyltransferases ( CHPF , CSGALNACT1 , CSGALNACT2 ) were expressed at lower levels in lesion cartilage.
Three genes have been identified causing familial CCM : KRIT1 / CCM1 , MGC4607 / CCM2 , and PDCD10 / CCM3.
Three groups of signs have been described : pathognomonic , highly characteristic and compatible.
Three groups were compared : ARB users ( HTN-ARBs ) , other antihypertensive drug users ( HTN-Other ) , and normotensives.
Three groups were examined : control , UVA and UVA plus red light.
Three housing stability patterns ( unstable housing , stable housing , and rare institutional dwelling patterns ) were identified.
Three hundred and eighty GPs responded ( response rate = @percent@ ) .
Three hundred and fifty-one patients with schizophrenia and @number@ unrelated healthy volunteers were recruited.
Three hundred and ninety consecutive S. aureus clinical isolates , submitted for routine diagnostic purposes were screened for PVL genes.
Three hundred and one older adults ( mean age = @number@ years ) completed the MoCA and also hearing and vision tests.
Three hundred and six patients with SALS from the Department of Neurology , West China Hospital of Sichuan University were recruited for this study.
Three hundred and thirty-three patients with schizophrenia under clozapine or olanzapine monotherapy were recruited.
Three hundred and twenty women ( 63-75 years ) without overt cardiac diseases and apparent mobility limitations were studied.
Three hundred four blinded evaluators completed a survey rating first impression on various measures of success for each photo.
Three-hundred-ninety-six older residents with chronic pain were recruited from @number@ nursing homes run by non-governmental organizations in Hong Kong.
Three hundred one patients completed the study.
Three hundred seventy-three individual tumors were analyzed.
Three hundred twelve patients with facial photodamaged skin were enrolled and underwent a single full-face treatment.
Three important findings emerged.
Three IMUs placed on the 5th lumbar vertebra , 7th cervical vertebra and the back of the head recorded the acceleration of the upper body.
Three independent common SNPs within the SOST region may collectively account for a significant proportion of the variation in serum sclerostin.
Three independent groups of young participants and one group of old participants were used.
Three independent masked observers scored the reaction product ( 0-8 ) .
Three independent physicians and patients evaluated improvement in acne scars @number@ weeks after the last treatment.
Three independent raters assessed these parameters using four-point scales on images of female subjects of two age groups.
Three indices of arterial stiffness were measured : brachial-ankle pulse wave velocity , large artery elasticity , and small artery elasticity.
Three in @number@ nurse practitioners used EHRs in @number@ ( @percent@ ) , and @percent@ of nonusers planned to adopt within @number@ months.
Three intervention groups were evaluated : a muscle force training group ; a balance and muscle force training group ; and a self-administered training group.
Three intervention studies using sesamin supplements indicated possible lipid- and blood pressure-lowering associations.
Three isoforms of HO were identified in the brain : inducible form ( HO-1 ) and constitutive forms ( HO-2 and HO-3 ) .
Three key dementia-specific considerations identified were capacity ( understanding , retaining and emotional processing ) , perceived vulnerability and family dynamics.
Three lines of evidence are used to identify the biological equivalent of a warranty period for humans and why it exists.
Three loci were significantly associated with circulating tPA levels ( P < 5.0×10 ( @number@ ) ) .
Three logistic models that discriminated the occurrence of hip fracture with QCT variables were obtained ( AUC = @number@ ) .
Three main clinical / anatomical variants have been described , each associated with distinctive pathology.
Three main findings emerged : First , younger adults were faster and more accurate on the task.
Three main themes were found.
Three major findings are presented.
Three major food sources , tea , legumes , and wines , contributed @number@ mg ( @percent@ ) of daily PA intake.
Three major nutritional sensors , mTOR , AMPK and Sirtuins are involved in the control of mitochondrial physiology.
Three major patterns of associations emerged with respect to predictors of subjective memory and subjective memory change.
Three matched controls were collected.
Three measures of cortisol were analyzed : waking levels , the cortisol awakening response , and the peak to bed slope.
Three measures of mortality were estimated : deaths , years of potential life lost , and the value of lost productivity.
Three meta-analyses defined a fall , and @number@ reported adverse events ( although minor ) .
Three methods for age estimation have been designated as the most reliable among the others : Greulich and Pyle , Demirjian and Mincer.
Three miRNAs ( miR-92a , miR-15b and miR-125a-3p ) were altered in both tissues.
Three-mm punch skin biopsies were obtained.
Three-m / o ATX mice were treated with the cardio-protective polyphenol catechin for @number@ months.
Three models evaluated the costs of speech planning , the costs of speech production , and the costs of speech output monitoring.
Three models of layers were used to investigate this pattern of frailty.
Three modules were reproducible , based on homology , when mapped against human-derived modules.
Three-month and 1-year survival and hospital re-admissions have been analyzed using Kaplan-Meier's curves.
Three monthly PRP injections were performed to the affected knees for a total of 3months.
Three-month mortality was recorded , as well as ADL score.
Three-month readmission and 1-year mortality rates related to higher CCI and CIRS-G scores.
Three months after hospital discharge , survival and living situation were assessed by a follow-up telephone interview.
Three months after , patients or their caregivers were called about the vital status , and EUR of patients.
Three months later , adverse outcomes including functional decline , high-healthcare demand or death were determined.
Three months later all features , except for pigmentations , once again showed a significant statistical improvement.
Three months of detraining , however , changed the favorable adaptations and underlined the need for uninterrupted exercise throughout life.
Three months post-intervention , only the increase in FFM remained statistically significant ( P < @number@ ) .
Three-month supplementation with arginine-enriched water ( Arginaid Water ) was performed on a subset of patients with PU.
Three mortality-related measures were estimated : deaths , years of potential life lost ( YPLL ) and the value of lost productivity.
Three motor factors were derived from several factor analyses ; fine motor , balance / upper strength , and flexibility.
Three mutations segregated in the family , two of which are novel mutations.
Three neuropathologists at @number@ sites performed blinded evaluations of these cases.
Three notions emerged : Getting started , Having a routine and Being with music.
Three of his friends became enthusiasts.
Three of our studies were of limited value since they did not include a validated measure of frailty.
Three of the five are imaging measures and two are cerebrospinal fluid analytes.
Three of them got pancreatic fistula and were self cured in @number@ months.
Three of the most differentially-regulated proteins were validated by immunoblotting.
Three of the nine patients had abnormal fat distribution and skin wrinkling.
Three of the @number@ enrolled patients demonstrated granuloma formation.
Three of the @number@ identified mutations impaired splicing , and @number@ resulted in a truncated protein.
Three of these GalNAc-Ts ( GalNAc-T1 , GalNAc-T4 and GalNAc-T6 ) were transfected into HEK293T cells to examine their impact on Aβ production.
Three of these SNPs map to the extended HNF1B promoter based on chromatin marks extending from the minimal promoter region.
Three older adults failed to show this even after @number@ training sessions.
Three ORA measurements were taken per eye , and the single best value used.
Three or more visits to a PCP in the year prior to the hospitalization established a PCP for a patient.
Three other cheese samples contained S. aureus.
Three other measures were also obtained , assessing phonological awareness , processing , and recoding.
Three other reasons may explain the increasing incidence of infertility.
Three outcomes were examined assessing restrictions in mobility , instrumental activities of daily living ( IADLs ) and social participation.
Three out of eight BDNF SNPs analyzed were significantly associated with measures of cognitive decline ( rs1157659 , rs11030094 , rs11030108 ) .
Three out of four games have good psychometric characteristics to measure working memory , visuospatial short-term memory , and planning capacity.
Three out of four sSNPs ( all epigenetic ) were associated with T2D and one with NDs ( branch site sSNP ) .
Three out of @number@ dynamic connectivity profiles were associated with age.
Three overarching themes are identified.
Three overarching themes - social support , system navigation , and access - emerged from the data.
Three PA categories were defined : inactivity , light PA , and moderate to heavy PA.
Three parallel groups will compare a control group with two experimental groups : psychosocial intervention and integrated pharmaceutical care at a psychosocial intervention.
Three participants dropped out , two due to knee pain and one for personal reasons.
Three patients died because of the impossibility to treat the ruptured aneurysm.
Three patients had a known heterozygous missense mutation in the PSEN1 gene ( p.H163R ) .
Three patients had preexisting tracheostomies.
Three patients had to be touched up for insufficient skin tension.
Three patients interrupted the trial : one had diarrhea ( under placebo ) , one for low adherence , and one for intercurrent pneumonia.
Three patients ( @number@ percent ) developed transient lagophthalmos from lower eyelid orbicularis paresis that resolved spontaneously.
Three patients presented acute suppurative thyroiditis , @number@ deep neck abscesses , and @number@ neck lump.
Three patients required antihypertensive medication.
Three patients showed improvement in self-efficacy scores and eight in clinical measures.
Three patients were lost to follow-up , and @number@ patients were deceased.
Three patients were male and @number@ were female.
Three patterns were extracted that showed high , medium , and non-scaling with global WMSA.
Three ( @percent@ ) of the facelift with SMMS patients required reoperation for dehiscence of the submental suspension.
Three ( @percent@ ) patients died within one month of GT placement.
Three phenotypes ( I , II , and III ) were detected , but the phenotype III was observed.
Three plausible classifications were submitted to the committee.
Three point mutations in the α-synuclein gene are associated with familial PD.
Three preclinical corticobasal degeneration cases and six age-matched end-stage corticobasal degeneration cases were included in this study.
Three progressors died from liver disease ( @percent@ ) .
Three quantitative studies were identified ( including one study which combined a physical exam with survey methods ) as well as three mixed method studies.
Three-quarters of respondents waited for 6-12 months of inactive disease before stopping methotrexate ( MTX ) or biologics , but preferences varied.
Three-quarters of smokers were in stable smoking or abstinent classes , but @percent@ were in classes with unstable abstinence probabilities over time.
Three readers , unaware of the clinical diagnosis , classified the images as either normal or abnormal by visual inspection.
Three recordings were made on each sample at baseline and then weekly for @number@ months ( quadruplicate per mo ) .
Three referred to , or consulted with , the intervention during the election.
Three representative spatial characteristics were analyzed per segments drawn on the paper : height , width and length.
Three researchers each read the articles and extracted factors.
Three researchers reviewed every scan , noting the absence / presence and distribution of pre-specified parenchymal findings.
Three researchers translated these instruments into Dutch.
Three researchers were involved in data analysis ( researcher triangulation ) , and @number@ conversations took place with experts.
Three reviewers independently assessed the included studies using the Cochrane Collaboration risk-of-bias tool.
Three reviewers selected studies , extracted data , and appraised the methodological quality.
Three scleral layers , normalized for depth , were examined.
Three SD subjects had a motion sense AI above the control group maximum.
Three secretases ( β- , γ- , and α-secretase ) are proteases that control the production of Aβ from amyloid precursor protein.
Three separate multiple linear regression models were developed to predict measured-height and reported-height respectively.
Three separate regressions examined whether planning , SWM and set-shifting independently predicted unimanual , bimanual , and sequencing scores for the older adults.
Three separate yet interconnecting circuits control executive function within the frontal lobe involving the dorsolateral prefrontal cortex , anterior cingulate cortex and the orbitofrontal cortex.
Three short socio-novels ( plays ) were presented by local farmers who served as actors.
Three sirtuin inhibitors were subjected to cellular studies , and all of them showed an increase in acetylation of Lys382 of p53 after DNA damage.
Three sites were investigated : the transverse forehead crease , lateral orbicularis oculi wrinkle ( crow's feet ) , and the nasojugal crease.
Three small colorectal cancers were missed.
Three stakeholder symposiums identified barriers and supports to implementation.
Three strategies were used in the data analysis procedure.
Three structured questionnaires were used in this study : personal characteristics questionnaire , interpersonal intimacy scale , and purpose in life test.
Three studies are reported on the development of a four-disc version of the Tower of London test of planning ability.
Three studies are reviewed that show how with practice subjects develop movement strategies that are predictable and robust.
Three studies did not control confounders and two found no effect of vaccination.
Three studies did not report an association between cognition and falls risk.
Three studies examined or reported on an association between hearing loss and the quality of physician-patient communication.
Three studies examined the outcome of anxiety ; @number@ of these found significant reductions in anxiety.
Three studies examined the self-enhancement function of autobiographical memory ( measured with subjective temporal distance of memories ) .
Three studies found significant effects on the quality of sleep of participants after @number@ months of doing yoga.
Three studies provided sufficient detail to enable assessment of compliance with the recommendation of exercises providing a moderate or high challenge to balance.
Three styles of high-quality care and poor-quality care have been identified.
Three such factors are the challenges of physical exercise , food deprivation / fasting , and social / intellectual engagement.
Three surface treatments were applied to the intaglio surface of the copings.
Three task conditions were used : @number@ and @percent@ probabilities of the target in the oddball task and self-timing.
Three tertiles were created for each test based on the calculated scores.
Three TERT mutation carriers had IPF ( IPF carriers ) .
Three thousand one hundred and fifty-nine Chinese adults aged @number@ years and older participated in the PINE study.
Three time periods were examined : daytime , nighttime , and @number@ hours.
Three transparent cups were filled with water , two of which were coloured green / pink rinsing by dissolving a tablet in the water.
Three treatments were delivered at 4-week intervals with follow-up visits.
Three trials in older people with heart failure showed that interventions delivered by a hospital pharmacist reduced the relative risk of admissions.
Three trials should be performed to reach high repeatability.
Three types of cough ( frequent cough , chronic persistent cough , and nocturnal cough ) were defined using questionnaires.
Three types of interventions are distinguished : reminiscence , life-review and life-review therapy.
Three types of non-verbal communication were observed and analysed using univariate and multivariate statistical methods.
Three Ultrasound Centers were involved ( Chieti , Italy , Bad Mergentheim , Germany , and Cluj-Napoca , Romania ) .
Three valid SNPs including rs1053049 , rs1800234 and rs8192678 in the PPAR and PPARγC1a gene were genotyped by TaqMan allelic discrimination assays.
Three variables were considered : ( a ) modification extension , ( b ) modification positioning and ( c ) modification type.
Three-way classification schemes based on binary support vector machine models demonstrate overall discrimination accuracies of @number@.7- @percent@ , depending on the protocol condition.
Three-way interactions showed that delay discounting interacted with financial planning and income to predict food insecurity ( P = @number@ ) .
Three weeks after middle cerebral artery occlusion ( MCAO ) , rats were treated with E2 for consecutive @number@ days.
Three were recruited from oncologist panels and @number@ from informal social networks of disabled women nationwide.
Three years of data have been collected on the historical behavior of color stability on our clinical displays.
Threshold in stage-specific embryonic glycotypes uncovered by a full portrait of dynamic N-glycan expression during cell differentiation.
Thresholds for detecting a gap between two complex tones were determined for young listeners with normal hearing and old listeners with mild age-related hearing loss.
Thresholds were identified and the parameters of the responses to 100dB nHL were calculated and compared among groups.
Threshold tracking testing has provided novel insights of peripheral nerve excitability in normal and pathologic conditions.
Thrombopoiesis was assumed to be the same in HVs and patients , whereas platelets degraded more rapidly in patients.
Thrombosis is a common pathology underlying ischemic heart disease , ischemic stroke , and venous thromboembolism ( VTE ) .
Thrombotic events occurring in either arteries or veins are the primary causes of fatal perioperative cardiovascular events.
Through a cognitive debriefing process , we assessed response processes validity-an initial stage of validity , necessary before more advanced validity assessment.
Through a content analysis and a visual textual analysis , we examined how older men were depicted in the magazine images and accompanying texts.
Through actions in the amygdala , this relationship may become especially important in stress-induced food or drug intake.
Through a literature search , we identified @number@ FS that could be calculated in ELSA wave @number@ ( 2004-2005 ) .
Through analyses of an estradiol ( E2 ) -treated hepatocyte cell line and mice , we showed that E2 signaling controls hepatocyte proliferation.
Through analysis EDTA oxidation processes by Fenton and UV-Fenton system , the results indicate that , just like combustion , AOPs are typical induction reactions.
Through an in silico lookup , we found no associations of the @number@ lead SNPs with coronary artery disease or stroke.
Through a qualitative data analysis of structured interview data , we also identified facilitators and barriers to acceptance of robots for partner dance-based exercise.
Through a series of weighted linear regressions , all @number@ steroids are compared by gender and age and to Wave @number@ measurements.
Through a simulated experiment , we investigate the optimal conditions of the memory model and validate the consistency of memory performance for lifelong learning.
Through a transconjunctival incision , the preseptal space was entered and excess orbital fat pads were excised.
Through bioinformatic approaches , we identified an analogous EGT transporter in the nematode , Caenorhabditis elegans.
Through developmental testing of interventions , LHIRP identifies promising practices at the individual , group life , intentional community , and city levels.
Through education , quality of life and advances in medicine , the average life expectancy is still increasing.
Through H3K18 deacetylation at specific promoters , SIRT7 controls a tumor-suppressive gene expression program that stabilizes the transformed state of cancer cells.
Through in-depth interviews with @number@ U.S.-based anti-aging clinicians and @number@ female anti-aging patients , we analyze attitudes towards BHRT.
Through interactions with p62 and HDAC6 , Prom1 regulates autophagosome maturation and trafficking , suggesting a new cytoplasmic role of Prom1 in RPE function.
Through its actions as component of the activating protein-1 ( AP-1 ) transcription factor , JunD potently represses cell proliferation.
Through its actions on target RNAs , AUF1 preserves genomic integrity , in agreement with the AUF1-elicited prevention of premature cellular senescence.
Through its direct skeletal actions , FoxO1 promotes osteoblast proliferation by maintaining protein synthesis and redox balance.
Through its diverse RNA functions , nucleolin is increasingly implicated in pathological processes , particularly cancer and viral infection.
Through its effect on osmoreceptors , we believe that sodium could prove a viable alternative to glycerol as a hyperhydrating agent.
Through its systematic as well as renal actions , Klotho is emerging as a principal calciophosphoregulatory hormone.
Through longitudinal modeling , we describe the relationship of HbA RESULTS : The median number of lipid assessments was @number@ ( range 2-39 ) .
Through modulation of gene expression , cis-acting variants represent an important source of phenotypic variation.
Through multiple lines of evidence , this evolutionarily conserved neurosignalling system has shown neuroprotective capabilities and is therefore a potential target for neurodegenerative disorders.
Through new partnerships and a commitment to addressing potential health disparities , farmers and families who can benefit from AgrAbility services will be broadly identified.
Through @number@ @number@ participants had confirmed deaths.
Throughout 2014-2015 a total of @number@ men were enrolled in this cross-sectional observational study.
Throughout a median follow-up of @number@ years , @number@ participants experienced an incident hip fracture and @number@ participants experienced a major osteoporotic fracture.
Throughout British Columbia , Canada , @number@ caregivers were interviewed in person for on average , over 1½ hours.
Throughout life , there is an aging of the immune system that causes impairment of its defense capability.
Throughout life , the T cell system adapts to shifting resources and demands , resulting in a fundamentally restructured immune system in older individuals.
Throughout the 10-months , the SRI + DIET + EX group utilized real-time accelerometer feedback for self-monitoring.
Throughout the analysis , P < 0.05 was considered statistically significant.
Throughout the intervention year volunteers provided mealtime assistance on weekday lunchtimes on the intervention ward only.
Throughout the life span , the brain is a metabolically highly active organ that uses a large proportion of total nutrient and energy intake.
Throughout the review we focus on the older patient with diverticular disease.
Throughout the same protocol , the neuromuscular economy ( electromyographic signal ) of the vastus lateralis was measured.
Throughout these processes , there is feedback and tension between the information-storing role and the physical properties of chromosomes.
Throughout the study , our robot used admittance control to successfully dance with older adults , demonstrating the feasibility of this method.
Throughout the world , people are living longer , and chronic and degenerative diseases are on the rise ( Bloom et al.
Throughout the world , the projected growth of Alzheimer's disease is dramatic.
Throughout this multiancestry study , we kept a focus on interancestry differences in HbA1c genetics performance that might influence race-ancestry differences in health outcomes.
Through repetition , words from two sources ( italic vs. bold text type ) differed in memorability.
Through research studies , protocols are being optimized and clinical results are becoming more reliable.
Through screening , we found that fusing thioredoxin with TALEs prevented aggregate formation , unlocking the full power of TALE-based genomic imaging.
Through support by external expertise , farmers could more effectively trade their pigs at lucrative town markets.
Through systemic release of OCN , bone delivers its energy-demanding information to other organs to satisfy its energy requirement.
Through that understanding , when desired outcomes are not achieved , we can answer why.
Through the CFCN certification process , nurses gain knowledge and skills to provide the care that can improve foot health for an aging population.
Through the cluster analysis strategy , it was sought to describe the specific care demands of the elderly population , using frailty components.
Through the drug screening of @number@ known compounds , we identified a unique compound , emetine.
Through the efforts of these Trainers and our online dissemination , more than @number@ reported end-learners have been taught parts of the EPEC curriculum.
Through their ascending projections to the cortex , the IC neurons regulate homeostasis and behavior by synthesizing aminergic and cholinergic neurotransmitters.
Through their bacterial ancestry , these molecules contribute to mounting an inflammatory response by interacting with receptors similar to those involved in pathogen-associated responses.
Through these pathways , educational attainment influences not only depression for an individual but also for one's spouse , particularly for women , and parents.
Through this method , there was no need to perform data normalization and transformation before data analysis.
Through this model , we hope to provide a novel evaluation and management health index that can be utilized in various health care fields.
Through this opportunity , nurses and allied health members from all levels were able to collaborate on strategies for this patient safety initiative.
Throwing events are further normalized for the decreasing weight of the implements with the increasing age of the Masters athletes.
THs are related to oxidative stress not only by their stimulation of metabolism but also by their effects on antioxidant mechanisms.
THS composition is affected by chemical transformations and by air-surface partitioning over time scales of minutes to months.
ThT also suppressed pathological features of mutant metastable proteins and human β-amyloid-associated toxicity.
Thumb tenodesis power decreased @percent@ to @percent@ , whereas finger tenodeses power increased @percent@ to @percent@.
Thus , a better understanding of the processes underlying the cardiac remodeling events that are set into play by hypertension is needed.
Thus , a bias toward limited diagnosis based on age alone is not justified.
Thus , a causal relationship between these drugs and atypical fracture has not been established.
Thus , ACE I / D genotype appears to play a role in modulating functional responses to exercise training in seniors.
Thus , ACF1 and its complexes play important roles in DSBs repair.
Thus , a close relationship between sleep disorders and AD has been largely hypothesized.
Thus , a consequence of ageing is reduced excess BF in response to thermal stress increasing susceptibility to thermal damage.
Thus , additional studies should be performed to assess the overall risk of blastomere biopsies during PGD procedures.
Thus , a deep understanding of the mechanistic processes confining the threat of aging-related radiosensitivity is currently of foremost relevance.
Thus , adiposity has a role as a mediator of the effect of malnutrition on both sarcopenia and osteoporosis.
Thus , AD may have a much larger impact on the health and wellbeing of our aging population.
Thus , adolescence might be the critical age range for the negative impact of diet as an environmental insult.
Thus , AD-Tau and CBD-Tau represent specific pathological tau strains that spread differentially and may underlie distinct clinical and pathological features of these two tauopathies.
Thus , after statistically adjusting the mean EI values for the differences in PA , there were still significant age-related differences in EI.
Thus , age affects the adjustment of cognitive control following a conflict.
Thus , age differences in functional brain activity could at least in part result from local atrophy.
Thus , age-related changes in prediction during comprehension generalize across task circumstances.
Thus , age-related changes in WM may contribute to the functional decline observed in the elderly.
Thus , age-related deficits in learning relations among items may be remediated using existing relational information within semantic memory as an analog for new learning.
Thus , age-related deterioration in temporal processing abilities also may be expected.
Thus , age seems to be a predisposing factor for OA , with mechanical overload being the likely triggering cause.
Thus , age-specific selection on parents may change if the environment produces birth-order related gradients in reproductive success.
Thus , aging compromises a predictive control of terminating gaze anchoring relative to pointing completion , which is difficult to overcome through short-term practice.
Thus , aging induces defective phagocytosis by alveolar macrophages and increases lung damage.
Thus , aging intervention might be a promising target for treatment and prevention of diverse age-related diseases.
Thus , aging intervention might be beneficial for treatment and prevention of diverse age-related diseases.
Thus , aging may result paradoxically from post-maturational expression of the same programmatic function for somatic transformation that previously provided individual benefit.
Thus , a great need exists to characterize the underlying mechanisms and ultimately identify strategies that prevent , delay , and even reverse frailty.
Thus , a literature review on retinal pathology in neurodegenerative diseases was performed.
Thus , ALK5 inhibition enhances anti-melanoma CTL responses through ubiquitin-mediated degradation of Smad4 in addition to the direct inhibitory effect on R-Smad phosphorylation.
Thus all partners and structures involved in normal and abnormal telomere maintenance , protection and lengthening can be considered as potential anti-cancer therapeutic targets.
Thus all SH2 domains will go on cell cytoskeleton formation.
Thus , a long-range conformational and functional communication specific to higher eukaryotes is found in human SerRS , possibly to coordinate translation with vasculogenesis.
Thus , alpha-synuclein may be a novel biomarker of aging , a factor that should be considered when analyzing its presence in biological specimens.
Thus , alterations in chromatin structure can both suppress and promote the onset of cancer , and both activities are inextricably linked to aging.
Thus , alterations might be confounded or driven by BOLD signal variance alterations.
Thus , although more research is needed in the field , the evidence available does not support the use of NSAIDs for AD treatment.
Thus , a multifaceted approach is introduced with presentation of a unique product formulation based on these research principles.
Thus , an adequate follow-up by a multidisciplinary team may lower complications associated with this therapy and thus improve survival.
Thus , analyzing the proteins ' BN topologies could contribute to the understanding of aging.
Thus , a network approach is becoming feasible , describing the interaction of a single polyphenol with cellular networks.
Thus , a new scenario emerges in which apparently unrelated diseases present common features , such as the remodelling of neuronal circuitries promoted by ageing.
Thus , an important genetic risk factor for Alzheimer disease does not affect risk of delirium.
Thus , an inverse relationship exists between adipocytes and osteoblasts in the bone marrow.
Thus , anti-angiogenic drugs are now recognized in the clinic as a major step forward for the treatment of cancers and ocular diseases.
Thus , antidiabetic drugs postpone spontaneous carcinogenesis in mice and rats , as well as chemical and radiation carcinogenesis in mice , rats and hamsters.
Thus , an understanding of the molecular processes controlling MSC senescence is crucial to determining the drivers and effectors of age-associated MSC dysfunction.
Thus , any genetic factors influencing human longevity may be associated with susceptibility to CMV and CMV-accelerated immunosenescence.
Thus , a pathological continuity between FTLD-TDP and ALS is supported at the level of the LMN system.
Thus , APOE genotype and age should be considered in the design of AD primary prevention treatment trials.
Thus , apoptosis / necrosis ratios were inverted in young versus elderly ( ≥65 years ) donors.
Thus , appropriate subgroup selection for intensive chemotherapy is likely to improve therapeutic outcome.
Thus , a preserved klotho function supports cardiovascular protection and may represent a prognostic tool and therapeutic target for cardiovascular disease.
Thus a proactive approach is important to screen for the likelihood of fall in the elderly.
Thus , a reduction of 1g / dl in pre-operative albumin is associated with an increased hazard of death of @percent@.
Thus , a region encompassing exons 8-11 seems essential for genome integrity.
Thus , are important subjects of research.
Thus , a relatively simple assay system that also provides rational results is urgently needed.
Thus , a relatively superior hydration status is associated with a quantitative reduction in urinary excretion of systemic oxidation products.
Thus , artifacts and key questions of correct interpretation can confound the readouts provided by anatomical MRI.
Thus , ASD should be closed at a younger age before the development of age-related LV diastolic dysfunction.
Thus , assessment of physiological systems integrity and of its dynamic interactions seems to be useful in the context of frailty management.
Thus , associations between micronutrients and other measures of vaccine response , such as cell-mediated immune parameters , should also be explored.
Thus , at least one SMAP gene , either SMAP1 or SMAP2 , is required for proper embryogenesis.
Thus a total of @number@ carbonylated proteins containing @number@ carbonylation sites were consistently identified in three replicates.
Thus , autophagy-upregulating therapies may be a strategy for the treatment for tauopathies.
Thus , Avns might reduce colon cancer risk through inhibition of macrophage PGE ( @number@ ) production and non-COX-related antiproliferative effects in colon cancer cells.
Thus , Aβ accumulation and apoE4 genotype result in a transient enhancement of leptin signalling that might lead to a leptin resistance state over time.
Thus Aβ seems to be a promoting factor in brain aging.
Thus , base rates of healthy individuals ' low scores are required to more accurately interpret neuropsychological results.
Thus , basic research is required to drive the development of novel therapeutics which are urgently needed.
Thus , because of the rapidly aging population in Japan , the development of new , effective drugs for AD is urgently needed.
Thus beta-myrcene is used widely in cosmetics , soaps , and detergents and as a flavoring additive in food and beverages.
Thus better educated individuals experience a slightly shorter period of faster decline before death.
Thus , \ "big data \ " can become \ "big \ " brain science.
Thus , blueberries are recognized as one of the most nutritious foods and cultivated worldwide.
Thus bone microarchitecture may be a determinant of bone fragility in men , which should be investigated in prospective studies.
Thus , both infused and inhaled nitrite are being studied as therapeutic agents for a variety of diseases.
Thus , both MSE and the mood-MSE relationship depended upon question wording.
Thus , both younger and older listeners used semantic cues to prepare changes in speaker setting.
Thus , breast WAT inflammation could be relevant for explaining the high incidence of estrogen-dependent tumors with aging despite diminished circulating estrogen levels after menopause.
Thus , brief descriptions of various currently available multifunctional smart materials and their possible applications to aging-related problems are presented.
Thus Ca ( 2 + ) -cAMP / PKA-dependent phosphorylation limits the rate and magnitude of increase in spontaneous AP firing rate.
Thus , cardiac stress in mice results in GFAT-1 activation that triggers a cytoprotective response.
Thus , careful analyses of phenotypic features and transmission properties in atypical cases may be useful to distinguish acquired from sporadic cases of CJD.
Thus , careful colonoscopic examinations of the proximal colon are necessary for elderly patients because SSAs in those patients may exhibit malignant potential.
Thus , changes in sex hormone levels with aging may contribute to the increased prevalence of anemia and thromboembolic stroke in men as they age.
Thus , children and adults may differ in how they infer credibility because of the cognitive demands of using calibration.
Thus , chronic arterial injury may overwhelm the ability of EPCs to maintain arterial homeostasis , particularly when EPCs capable of arterial repair become exhausted.
Thus chronic erythrocytosis results in sustained activation of inflammatory pathways , vascular dysfunction and blood-brain barrier disruption.
Thus , circRNA 100269 level was downregulated in GC and correlated negatively with that of miR-630.
Thus , circulating EVs-or specific EV cargoes-are being utilised as putative biomarkers of disease.
Thus clinical rationales can be provided for assessing the subjects of any age during salivary gland imaging and aging-related researches.
Thus , clinicians should consider prescribing exercise and recreational activities in the cognitive rehabilitation of chronic stroke survivors.
Thus , clinicians taking care of elderly with diabetes must take this into consideration and prioritize treatment accordingly.
Thus , coexistence of CV and kidney disease complicates diagnosis , propagates pathophysiology , adversely affects prognosis , and hinders management.
Thus , cognitive control processing appears to reach peak performance and efficiency in younger adulthood , marked by improved task performance with less neural activation.
Thus , combinations of slightly defective alleles might induce disease phenotypes in humans , acting as quantitative trait loci.
Thus , comparable transcriptional regulatory networks that operate throughout the lifespan underlie different phenotypic processes during Aging compared to Development.
Thus , conditions that favor protein synthesis can enhance the rate at which damaged proteins accumulate.
Thus , conversations between clinicians and patients , as well as shared decision making , are important.
Thus , COPD should be considered as a component of multimorbidity and common disease pathways , particularly accelerated ageing , should be targeted.
Thus , coronary atherosclerotic burden and vascular function have to be seen as two different entities.
Thus , country-level strategies of successful aging in Europe should target socio-ecological factors such as GII , GNI , and DCI value.
Thus , CR can counteract a genetically unfavorable background , suggesting a possible preventive strategy.
Thus , cross-species prion transmission may be much less efficient in aged individuals.
Thus , current approaches to recognizing and managing this disorder may be inadequate.
Thus , current smoking was independently associated with decreased P. jirovecii antibody responses.
Thus , C-Xyloside may be useful in improving the quality of skin.
Thus , cycles of a 5-day FMD are safe , feasible , and effective in reducing markers / risk factors for aging and age-related diseases.
Thus , damage to the colonic ECM from hernial disease is conducive to diverticulosis , but hostile for cancer.
Thus , decrease in telomere length was found to be important in determining both , the variations in longevity and age-related diseases in an individual.
Thus , degradation of prelamin A is expected to improve the disease phenotype.
Thus , delineating potentially HIV-specific pathogenetic mechanisms is crucial in order to tailor novel strategies for prophylaxis and treatment.
Thus , delirium is still unexplored not only in the psychiatric field , but also in all medical services.
Thus , dermal CD271 + cells are closely associated with wound healing.
Thus , dietary bioactives have potential to restore the population of microglial cells in the senescent brain to a more quiescent state.
Thus , dietary nitrate may also be important when increased blood flow in hypoxic or ischemic areas is indicated.
Thus , different consumption levels of the major specific fat types , rather than total fat intake itself , appeared to influence cognitive aging.
Thus , different forms of tau aggregates are involved in the different pathological changes that occur in tauopathies.
Thus , different interventions have been carried out attempting to improve these aspects.
Thus , disruption of NOS2-Arg1 interaction may represent a therapeutic strategy to attenuate age related vascular endothelial dysfunction.
Thus , disruption of sMAC provides a foundation for rejuvenating immunity during aging.
Thus , doses of anti-VEGF may have to be tapered to decrease the concentration gradient and to slow down the rate of diffusion of VEGF.
Thus , drift emerges as a promising biomarker for premature or biological ageing , and could potentially be used in geriatrics for disease risk prediction.
Thus , drug dosage may require adjustment for the pediatric population to ensure the desired therapeutic outcome and to avoid side-effects.
Thus , dynamic connectivity analyses can enrich understanding of age-related differences beyond what is revealed by static analyses.
Thus , DYRK1B is a target for enzymatic inhibition in order to increase cellular NKX3.1.
Thus , EAK proteins regulate the activity of nuclear DAF-16 / FoxO.
Thus , early diagnosis was crucial to improve outcomes.
Thus , education was a significant predictor of retrospective metamemory accuracy in healthy aging and AD.
Thus , effective facial rejuvenation requires a comprehensive paradigm that identifies and addresses all anatomic elements involved in the aging process.
Thus , effective , low-cost , and low side-effect interventions for the treatment and prevention of cognitive decline are urgently needed.
Thus , eight CRF receptor-expressing areas displayed eight distinct sex differences.
Thus , either long alleles of NOS1 ex1f-VNTR are protective against disease or conversely , short alleles predispose to earlier onset of disease.
Thus elderly individuals usually present chronic low-level inflammation , higher infection rates and chronic diseases.
Thus , elderly women classified with high pro-inflammatory status for IL-6 should receive further health care attention to prevent this deleterious condition.
Thus , elite marathon runners should program their long-term training to obtain maximal performance during their late 20s.
Thus , elucidating the full complement of regulatory pathways that control BACE1 expression is key to identifying novel drug targets central to the Aβ-generating process.
Thus , elucidating the spatial and temporal evolution of the molecular pathways in AD remains to be a daunting task.
Thus , endogenous FoxO1 is a positive transcriptional regulator of SIRT1.
Thus , enhanced SUMO-2 conjugation led to increased apoptosis and played a pathogenic role in the development of cardiomyopathy and heart failure.
Thus , epigenetic changes upon aging seem to reflect biological aging of blood.
Thus , evaluation of both locomotive and non-locomotive activity is important in the overall assessment of PA.
Thus , even in the era of targeted therapies , CLL with alterations in the ATM / p53 pathway remains a clinical challenge.
Thus , even late-stage interventions hold promise to boost cognitive reserve and thus reduce the prevalence of Alzheimer's disease and other age-related problems.
Thus , evidence from studies using routinely accumulated clinical data are increasingly valued.
Thus examining the involvement of CK2 downregulation in chondrocyte death is an urgently required task.
Thus , except for aging , it is very rare to have truly steatotic pancreas in the absence of certain human diseases.
Thus , excessive autophagy is associated with several diseases that cause muscle wasting , and it promotes the loss of muscle protein.
Thus , excessive or chronic inflammation initiated by numerous insults exacerbates tissue damage and - at least in some settings - promotes oncogenesis.
Thus , exercise training plus weight loss increased pancreatic β-cell function in a linear dose-response manner in adults with prediabetes.
Thus , experimental and clinical evidence show that insulin action influences cerebral functions.
Thus , failure of long-distance intracellular transport can deprive axons of one , few , or many cargoes.
Thus far , a dozen of genes have been identified that are responsible for inherited PD.
Thus far , compounds that mediate these effects have shown great potential in both preclinical animal studies as well as in early-stage clinical trials.
Thus far curcumin was shown to induce death of cancer cells.
Thus far it is not well understood why ADHD and depression are so strongly interrelated.
Thus far , mitochondrial therapeutic strategies have shown promise at the preclinical stage but have had little-to-no success in clinical trials.
Thus far , no imaging tool exists to analyze the aging process of the hand.
Thus far only a limited number of robust longevity loci have been detected in either candidate or genome wide association studies.
Thus far , published studies have described VR-based applications in the identification and treatment of deficits in navigational skills in ambulation and driving.
Thus far , several monoclonal antibodies have been reported to cause PML.
Thus far , studies on LAA morphology have largely focused on those patients with atrial fibrillation ( AF ) .
Thus far , the involvement of adiponectin in the influence of metabolism on reproduction in men is limited.
Thus far , the presence of deep forehead compartments has not been confirmed.
Thus far , unbiased investigations of the genetic determinants of plasma fetuin-A concentrations have not been conducted.
Thus , fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic dietary interventions.
Thus , fecundity decreases as age increases , with a more rapid decline after the mid-30s.
Thus , few patents describing SIRT inhibitors have been found in @number@ - @number@ period.
Thus , FGF-23 functions as a phosphaturic hormone and a counter-regulatory hormone for vitamin D , thereby inducing negative phosphate balance.
Thus , finding novel ways to complement resistance training to improve muscle response and ultimately quality of life among older individuals is critical.
Thus , five-year mortality rate is decreasing but remains higher than @percent@ in recent years.
Thus , for a correct therapeutic approach it is necessary to interpret the clinical and biochemical elements in correlation with the medical history.
Thus , for both medical and socioeconomic reasons , it is imperative that ageing is made to yield to intervention.
Thus , for comprehensive treatment of late-life depression , it may be necessary to address both the affective and cognitive deficits.
Thus , forms of distinction based on class relations may still play an important role in the lived experience of dementia.
Thus , for the first time , we propose to examine gray matter changes using diffusion MRI in the context of aging.
Thus , fragility fractures represent a challenge for health professionals and decision makers of the twenty-first century.
Thus , fully understanding this link is a mandatory step before bringing caloric restriction into practice.
Thus , further elucidation of the involvement of S-nitrosylation in brain development may offer potential therapeutic avenues for neurodevelopmental disorders.
Thus , further systematic and particularly focused research is needed on sex differences in pharmacokinetics.
Thus , future high-quality and in particular longitudinal research is required to confirm or refute these relationships and to further elucidate pathophysiological mechanisms.
Thus , future investigations could determine the effect on FA in OAs by improving EF.
Thus , future studies aimed at pinpointing optimal protein intake in specific populations of older people need to include measures of physical function.
Thus , gait variability under dual-task in individuals with SMI expressed by their relatives can be a potential biomarker of AD.
Thus , gene reporter analysis revealed widespread OSG-1 expression in muscle and neurons.
Thus , genetic risk factors for AUD , but not MDD , vary with age , suggesting that AUD has age-dependent heritable etiologies.
Thus , geriatric patients are no longer confined to a life of inactivity.
Thus GG may serve as a good suspending agent requiring no further aid in suspension redispersibility.
Thus , glycitin treatment produces anti-aging effects including increased total collagen in the culture media , decreased elastase , and decreased β-galactosidase.
Thus , halting the progression of diabetic nephropathy in elderly diabetic patients is a clinically important issue.
Thus , heart failure is a major and growing health problem.
Thus , herbal therapy may be an alternative strategy for treatment of wounds.
Thus , hESC-IPs exhibit robust tolerance to exposure to vitrification solutions in relevant conditions.
Thus , higher educational attainment was associated with a delay in diagnosis of dementia / MCI in the face of a growing neuropathological load.
Thus , higher instability of morning recovery sleep may account at least in part for the increased IED yield in SD-EEG in TLE patients.
Thus , high levels of form vision degrade in parallel with higher levels of motion perception and likely result from similar causes.
Thus , HNE and Pr3 inhibitors may prove to be targets for the generation of agents in the treatment of neutrophilic inflammatory disease.
Thus , how PA levels change over longer periods of aging may be an important contributor to cognitive and neural protection.
Thus , ICRF-193 induces damage at telomeres properly capped by TRF2 but not by POT1.
Thus , ICU admission of octogenarians is considered controversial.
Thus identification of people with early stage AMD is important to design and implement preventative strategies for late AMD , and determine their cost-effectiveness.
Thus , identification of pharmacological properties of plants / plant-derived components are of utmost importance to be explored.
Thus , identifying senescent cells in in vivo and in vitro has an important diagnostic and therapeutic potential.
Thus , identifying the mechanisms of EMT activation could be meaningful.
Thus , IgG glycosylation appears to be closely linked with both chronological and biological ages.
Thus , IKKβ activation leads to ubiquitination within the kinase domain and assemblage of a K63-ubiquitin conjugated signaling platform.
Thus , IL-10 @number@ G / A polymorphism seems to play a role in the pathway to longevity in Jordanian men.
Thus , IL-1β is a potential treatment target.
Thus , IL-6 is an independent risk indicator for accelerated global functional decline in the oldest old.
Thus , impaired plasticity of mitochondrial function is an intrinsic phenomenon that probably occurs independently of lipotoxicity and reduced glucose uptake.
Thus , improved food security collides with the biologically evolved mechanisms to store excessive calories in preparation for a famine that never came.
Thus , in a majority of patients , PoAF becomes a manifestation of an underlying arrhythmogenic substrate that is unmasked after acute surgical stress.
Thus , in CD1 mice whole-life arsenic exposure induced lung tumors at human-relevant doses ( i.e. , @number@ and @number@ ppb ) .
Thus , in chronic tinnitus , limbic-system damage and resulting inefficiency of auditory-limbic interactions prevents proper compensation of the tinnitus signal.
Thus , increased GH availability stimulates matrix collagen synthesis in skeletal muscle and tendon , but without any effect upon myofibrillar protein synthesis.
Thus , increased levels of ubiquitin conjugates in cells seem to be an indicator of mild oxidative stress.
Thus , increasing the efficiency of the delivery of healthcare services through the use of modern technology is a pressing issue.
Thus in daughter cells the Src SH2 domain necessary both for cytoskeleton formation and tyrosinase activization is activated.
Thus , induction of a Bak-dependent mitochondrial apoptosis program in response to oxidative stress is a key mechanism of AHL in C57BL / 6J mice.
Thus , induction of mitochondrial metabolism may be considered part of a generally protective mechanism to prevent cardiomyopathy and cardiac failure.
Thus , inflammaging is a strong candidate to connect age and cancer.
Thus , inflammation may play an important role in bidirectional associations between pain and sleep.
Thus , inflammation-promoting chronic stress may create a vicious cycle of aggravated microglial dysfunction accompanied by increased Aβ accumulation , collectively exacerbating neurodegeneration.
Thus , information on the circadian variation of these parameters in an ambulatory population is lacking.
Thus , in healthy adults , age differences in NAWM diffusion properties are not a major contributor to age differences in RT components.
Thus , inhibition of 11β-HSD1 by these compounds can be further investigated to delay or prevent UV-mediated skin damage and skin aging.
Thus , inhibition of microglial over-activation may have a therapeutic benefit for the treatment of neurodegenerative disorders.
Thus , inhibition of NFκB signalling alone is not responsible for the stimulation of eryptosis by parthenolide or Bay 11-7082.
Thus , inhibition of Synj1 may ameliorate Aβ-associated impairments , suggesting Synj1 as a potential therapeutic target.
Thus , in light of demographic change and aging societies , they are becoming a growing issue for public health.
Thus , in men , vertebral fractures and their severity are associated with impaired cortical bone , even after adjustment for aBMD.
Thus , in older patients on nephrology care , the risk of ESRD prevailed overmortality even when eGFR was not severely impaired.
Thus , inpatient capacity would have to expand @percent@ more than population growth to meet demand.
Thus , in rodents aging is associated with the altered expression and activity of both orexigenic and anorexigenic peptides.
Thus , insights gained from the studies of mitochondrial dynamics and quality control in Drosophila are likely to be of general significance.
Thus , institutions and policies matter for the consequences of population aging.
Thus , insulin sensitivity and mitochondrial function may not be causally related , but mutually amplify each other during aging.
Thus , integrity of white matter tracts connecting frontoparietal attention networks contributes to search performance in younger and older adults.
Thus , intelligence has been associated with cognitive reserve or resilience in normal aging.
Thus , interaction between these two sets of beneficial regulatory mechanisms can become detrimental in situations of ample calorie supply.
Thus , interindividual variability in ventral striatal presynaptic dopamine reflects a balance in the behavioral expression and the neural signatures of model-free and model-based control.
Thus , in terms of accuracy , high throughput , and sensitivity , HT-MEFB exhibits considerable potential for hMPV detection in clinical settings.
Thus , intervention with IFNβ therapy is appropriate for all stages of MS except PPMS or non-relapsing SPMS.
Thus , in the blood compartment chemokines attracting mainly monocytes were up-regulated by RES , while those attracting T lymphocytes or neutrophils were diminished.
Thus , in the context of caring for older adults with DM , comorbid depression presents special challenges and opportunities for clinicians.
Thus , in the present study , we devised a brief , computer-aided short-term VSM test.
Thus , in this division , the working conditions and organization had more impact than the aging process on the individuals ' daily work routine.
Thus , intranasal insulin improved tissue perfusion of the occipital cortical brain region and the thalamus in older adults.
Thus , investigation of the brain in ASD poses particular methodological challenges , which must be addressed to enable the comparison of results across studies.
Thus , involuntary autobiographical remembering relates differently to aging than daydreaming and other forms of spontaneous and uncontrollable thoughts.
Thus , IR dysfunction may have a role in the progression of HAND and could represent a biomarker for the presence and severity of HAND.
Thus , it appears that lasers are safe and effective as long as the patients are carefully selected for treatment.
Thus it appears that these high-risk individuals are often managed with more conservative strategies , compared to younger patients.
Thus , it can be concluded that age is a statistically significant factor affecting the success of infertility treatment by IVF.
Thus , it can be concluded that the blood viscosity seldom affects the attenuation of a pulse wave.
Thus , it comes as wonderful news that glomerular research is advancing at a remarkable pace.
Thus , it has become increasingly common to treat asymptomatic patients with severe aortic stenosis.
Thus , it has been postulated that this gene plays specific roles in pathogenesis of PD.
Thus it highlights the importance of there being future studies that are better targeted on designing environments for the elderly.
Thus , it is argued that basal hypercortisolemia merits further scrutiny regarding AD causation and development.
Thus it is crucial to evaluate age-related changes in hASCs , as the elderly are a group that will benefit most from their considerable potential.
Thus , it is essential to better understand the mechanisms and identify the signalling pathways at play in the control of autophagy in skeletal muscle.
Thus , it is expected that changes in DNA ( DNA mutation ) influence human characteristics and features.
Thus it is fundamental that assessments of informal care are valid.
Thus , it is important that healthcare professionals should focus activities toward maintaining older people's mobility as a means of enhancing their HRQoL.
Thus , it is important to develop strategies to keep participants who are at high risk in Web-based interventions.
Thus , it is important to go into the effect of ginkgo aglucone flavone to immune function.
Thus , it is likely that strategies aimed at these mechanisms will lead to future therapies for AD.
Thus , it is more important than ever to develop effective hormonal treatment strategies to protect aging women.
Thus , it is not chronological age as such but cognitive competence that may explain age-related decreases of temporal acuity.
Thus , it is of critical importance to develop programs aimed at preventing or improving these conditions to reduce hospital use in this population.
Thus , it is possible that the accelerating atrophy with increasing age is due to preclinical AD.
Thus , it is unknown whether these group differences in learning are due to reward processing or learning in general.
Thus it may be considered to be a pro-hormone.
Thus , it now seems crucial to develop a prospective study , which will help understand the progression of the decision-making process over time.
Thus , it seems hard to conclude that some processes considering tracheal cartilage morphokinesis always precede others.
Thus , its true prevalence is certainly higher than the surveys imply.
Thus , it takes a rare and somewhat particular situation to uncover the negative effect.
Thus , it will be important for future research to determine the mechanisms that regulate estrogen receptor expression during aging.
Thus it would be advantageous to consider aging itself as a therapeutic target , potentially stemming multiple age-related diseases simultaneously.
Thus , klotho seems to be a new player in the intricate regulation of the GH / IGF-1 axis.
Thus , knowing where to listen has the potential to compensate for age-related decline in attentional switching in a highly variable cocktail-party environment.
Thus , knowledge about older adults and community-based care is imperative for social work practice.
Thus , learning-related intrinsic changes can facilitate future synaptic plasticity and learning.
Thus , little is known about the brain predictors of individual differences in growth trajectories of numerical abilities.
Thus , loneliness is a significant contributor to poor SRH among aging people.
Thus , longevity is limited by an intrinsic trade-off between optimal tissue function and disease.
Thus , lower insulin sensitivity in the elderly could result from age-related diminished energy metabolism or from lifestyle-related abnormalities.
Thus , lower testosterone levels was only associated with subthreshold symptoms of anxiety and depression.
Thus , low family background and low personal education amplify each other.
Thus , lung cancer patients are often blamed for their illness and may seek to avoid this blame by concealing their diagnosis from others.
Thus , lysosomal cholesterol drives mTORC1 activation and growth signaling through the SLC38A9-NPC1 complex.
Thus major mental disorders are already prevalent among the Korean elderly and are likely to increase rapidly.
Thus , malnutrition and infection often act synergistically to increase morbidity and mortality.
Thus , many factors other than mere chronological age will contribute to treatment tolerance and outcome in the older patients with cancer.
Thus , many researchers are working toward finding effective therapeutics for AD focused on Aβ hypothesis , although there has been no success yet.
Thus , may help to improve the outcomes of organophosphate poisoning patients.
Thus , measures to reduce the diabetic burden are public health concerns.
Thus , mice lacking Sirt3 provide a model that mechanistically connects aberrant ROS , the Warburg effect , and carcinogenesis.
Thus , microRNA-34 family members could act as prognostic markers and therapeutic targets in human cancers.
Thus , miRNAs may serve as novel biomarkers and / or therapeutic targets for vascular disease.
Thus , mitochondrial DNA has characteristics different from nuclear DNA.
Thus , mitochondrial regulation by SIRT3 is likely much more complex than initially appreciated , potentially involving both direct and indirect mechanisms.
Thus , mitoOS-induced NET formation is a potentially new therapeutic target to prevent atherosclerosis progression during aging.
Thus , MK2-mediated phosphorylation of RIPK1 serves as a checkpoint within the TNF signaling pathway that integrates cell survival and cytokine production.
Thus , modifying these risk factors and identifying protective factors represent important strategies to prevent and delay disease onset and to decrease the social burden.
Thus , modulating autophagy represents an attractive future therapeutic target for treating cardiovascular disease.
Thus , modulating TDP-43 acetylation represents a plausible strategy to fine-tune TDP-43 activity , which could provide new therapeutic avenues for TDP-43 proteinopathies.
Thus , modulation of cellular senescence is considered as a potential pro-longevity strategy.
Thus , modulation of EMG amplitude plays a larger role in balance recovery than EMG timing in this context.
Thus , more attention should be paid to Al-Baha area in the future schistosome control programmes.
Thus , more bioactive components particularly cardiotonic and analgesic compounds should be identified through bioactivity-guided isolation strategies.
Thus , more detailed mapping of callosal growth processes is desirable to create a normative reference.
Thus more pharmacological mechanisms on main active compounds ( TBII , TAIII , mangiferin and other ingredients ) are necessary to be explored.
Thus , more regions of diminished activation were observed in the frontal and parietal regions with increasing task difficulty.
Thus more work is needed focusing on the effects of aging vs. estrogen loss on the cardiovascular system.
Thus motor overflow can be modulated by higher order cognitive control with directed attention.
Thus , MPO-mediated oxidation may be implicated in the mechanism that leads to amyloid deposition in the atherosclerotic plaques in vivo.
Thus , MR is characterized by the reduced utilization of selenium due to a specific defect in GPx1 expression.
Thus , mTOR becomes an important therapeutic target for AD.
Thus , much research has focused attention on the potential mechanisms of the indole in modulating expression and / or activity of sirtuins.
Thus , multi-modality exercise training improved executive performance in persons with a SCC independent of mind-motor training.
Thus , multiple concomitant etiologies of brain damage and premorbid characteristics contribute to the uncertainty of AD clinicopathologic correlations based only on tangles and plaques.
Thus , multiple hits in NADH dehydrogenase and COX activity-impairing genes represent the molecular basis of oxyphil cell transformation in the parathyroids.
Thus , multiple OPA1 functions are modulated by local CL conditions for regulation of mitochondrial morphology and quality control.
Thus , musicians offer an excellent human model for studying the brain effects of acquiring specialized sensorimotor skills.
Thus , mutations in VPS26A may be associated with PD.
Thus , NaDC3 promotes cellular senescence probably by inhibiting NAD ( + ) -dependent SIRT1.
Thus , NE stimulation may prevent memory loss in Ts65Dn mice , and may hold promise for treatment in individuals with DS and dementia.
Thus , neuroscientific probes may allow for the elucidation of psychosomatic mechanisms.
Thus , new investigations are necessary for pharmacological development in AD.
Thus , new treatment modalities are urgently needed.
Thus , novel research approaches are needed to better guide evidence-based clinical practice.
Thus , novel therapeutics that enhance Nrf2 signalling are an attractive approach to treat these diseases.
Thus , @number@ men were invited , and @number@ were examined in @number@ at age @number@
Thus , nursing interventions which focused on ERA could help enhance physical activity in middle aged adults.
Thus , nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss.
Thus , obesity is now regarded as an independent risk factor for atherosclerosis-related diseases such as coronary artery disease , myocardial infarction and stroke.
Thus , obesity per se appears to suppress gonadotropin production , and moderate hyperandrogenemia in women appears to stimulate LH.
Thus , obesity seems to be protective against forearm osteopenia in Lebanese women.
Thus , objective gait parameters may serve as surrogate markers for the use of walking aids in patients with gait and balance impairments.
Thus ocular biomarkers point to a potential avenue for an earlier , relatively low-cost diagnosis in order for therapeutic interventions to be effective.
Thus , older adults are encouraged to have as many good lifestyle habits as possible to reduce the risk of depressive symptoms.
Thus , older adults are more at risk of dehydration because they may replenish fluids at a slower rate.
Thus , older adults have difficulties in concurrent control of inhibiting hand movement and initiating eye movement at a target within a sequence.
Thus , older adults process irrelevant stimuli more like relevant ones , thereby overloading their information processing system.
Thus , older adults significantly modulated movement speed and motor coordination to maintain similar levels of stability and variability compared to their younger counterparts.
Thus , older people's balance is potentially vulnerable to interference from postural adjustments induced by thoughts about past or future actions.
Thus , older subjects ' under-recruitment of and reduced functional coupling between these regions may specifically underlie age-related changes in working memory updating.
Thus , oligomerization of Ca ( v ) β subunits represents a novel and essential aspect of calcium channel regulation.
Thus , original research studies incorporating chronic eccentric exercise interventions in the older adult population were included in this review.
Thus , OS and inflammation may occur in the diabetic kidney at an early time.
Thus , osteoarthritis can be related to metabolic syndrome or to an accumulation of metabolic abnormalities.
Thus , osteoarthritis may have a systemic metabolic component.
Thus , osteoblast-derived WNT16 is a previously unreported key regulator of osteoclastogenesis and fracture susceptibility.
Thus , OTUB2 fine-tunes the speed of DSB-induced ubiquitination so that the appropriate DNA repair pathway is chosen.
Thus , our aim was to explore the impact of FTO on AD and dementia risk.
Thus , our data also show that age-related reductions in prestimulus activity do not always lead to inefficient performance.
Thus , our data on physiological processes and subjective experiences are compatible with the hypothesis that new sensorimotor contingencies can be acquired using sensory augmentation.
Thus , our data provided new clues for exploring the pathogenesis of sALS.
Thus , our findings suggest that the SIRT1-mediated epigenetic inhibition of PAI-1 expression exerts a protective effect in vascular endothelial senescence.
Thus , our new findings open the possibility for club cell-targeted therapy to become a strategic option for the treatment of IPF.
Thus our novel findings firstly revealed the mechanism of skin aging under PAH contamination and provided potential strategy for clinical application.
Thus , our results indicate an undertreatment of osteoporosis in dementia.
Thus , our results provide a comprehensive view of how glycolysis modulates H3T11 phosphorylation.
Thus , our results suggest that ARFGAP3 is a novel androgen-regulated gene that can promote prostate cancer cell proliferation and migration in collaboration with paxillin.
Thus , our results suggest that developmental increases in face-selective regions ' sensitivity to face identity improve perceptual discrimination of faces.
Thus , our results suggest that the ACTN3 R577X genotype is associated with lower-extremity muscle function in the Japanese population.
Thus , our studies unravelled the potential beneficial effects of targeting P2Y2 or P2Y12 receptors to counter AVP resistance in lithium-induced NDI.
Thus , our study elaborates a novel epigenetic cascade of renal fibrogenesis and reveals the potential therapeutic targets for treating the renal fibrosis-associated kidney diseases.
Thus , our study reports a novel mechanism underlying NPC carcinogenesis , and provides a potential novel diagnosis and treatment biomarker for NPC.
Thus , our study shows that the ageing workforce can be reached through specifically designed preventive interventions.
Thus , our study substantiates the role of M1 in adapting to aging-related weakness and subtending strength and muscle activation across age groups.
Thus , our study suggests that CHCHD2 is probably not involved in the etiopathogenesis of PD in our population.
Thus , our study suggests that progerin-induced aging can be used to reveal late-onset age-related disease features in hiPSC-based disease models.
Thus , our understanding on early neuropathy in these diseases remains relatively limited.
Thus , oxidation and inflammation are interlinked processes and have many feedback loops.
Thus oxidative stress in lymphocytes may particular interest in aging and may play important role in immunosenescence.
Thus , p16 ( INK4a ) / Rb-driven stem cell senescence is causally implicated in the intrinsic defective regeneration of sarcopenic muscle.
Thus , P2X7 activation is unlikely to be involved in the removal of senescent RBCs or stored RBCs after transfusion.
Thus , pain in the spine may be part of a pattern of poor health , which increases mortality risk in the older population.
Thus , pancreatic ductal adenocarcinoma is projected to become the second leading cause of cancer-related death by @number@
Thus , paternal age becomes an emerging issue.
Thus , PA thresholds relative to CRF may be an alternative approach.
Thus , patients who have received lung transplants should be advised to return to work if possible.
Thus , patients with epilepsy in AD often respond well to medication.
Thus , perceived burdensomeness may be the necessary risk factor for suicide ideation.
Thus @percent@ of the subjects showed waning antibody titers by Day @number@
Thus , persistent vascular normalization could be an alternative goal of anti-angiogenic cancer treatment.
Thus , pharmacological reduction in ROS levels has been proposed as a potentially effective treatment for patient with this disorder.
Thus , pharmacological treatments have been aimed at modulating the activity of bone cells.
Thus , physical inactivity is a model of frailty in experimental animals.
Thus , physical inactivity is likely to become a larger problem in our aging population.
Thus , physiological aging presents numerous unanswered questions , particularly with regard to changing metabolic patterns.
Thus , physiological immunosenescence may render older adults susceptible to RA , and premature immunosenescence may contribute to the development of RA in young adults.
Thus , PIs might promote vascular senescence in HIV-infected patients ; and statins might exert beneficial effects in these patients.
Thus , PK has been a crucial tool to detect and , thereby , control the spread of prions.
Thus , Pmax-rel and the %EFI appear to be suitable as normative indices applicable to different human populations for the assessment of physical function.
Thus podocytes appear to play an important role in the pathogenesis , evaluation and therapy of age related glomerulosclerosis.
Thus , population aging in the United States may have catastrophic results if interventions are not found and implemented.
Thus , preclinical Alzheimer's disease could be an important target for therapeutic intervention.
Thus prefrontal cortex activity indexes emotion in the elderly , but not the young.
Thus , prevalence rate of AF in older women is elevated , mainly due to their longer survival.
Thus , primary health care costs constituted about @percent@ of the total median cost in the intervention group and about @percent@ in the control group.
Thus , problems with alcohol in old age will possibly increase as they grow older.
Thus , processes of elastic fibers degeneration and lysis run faster by comparison with those of collagen fibers degeneration.
Thus , prompt termination of the stress response is essential to prevent negative effects of inappropriate levels of CRH and glucocorticoids.
Thus , pro-oxidant conditions increase APP levels and enhance BACE1-mediated APP processing and in doing so might contribute to pathogenesis in AD.
Thus , prospective investigation of lung function changes including novel scientific methodology has been advocated.
Thus , providers need to be attentive to the diverse sexual health needs of older adults.
Thus , psychological treatments should also be considered in the management of IBS in the elderly.
Thus , public health programmes should be targeted toward these disadvantaged subpopulations among men which seem to be related primarily to socioeconomic characteristics.
Thus , recognition of MRI manifestations is important to allow appropriate management , to avoid misinterpretations and in most cases to avoid biopsy.
Thus reduced convective heat loss during exercise at @number@ m was partially caused by reduced cutaneous vasodilation due to enhanced PV loss.
Thus regional strain variations may be predictive of the progression of axonal damage in glaucoma.
Thus , regular physical activity is a good strategy to attenuate age-related general decay of muscle structure and function ( ClinicalTrials.gov : NCT01679977 ) .
Thus , regulation of protein conformation by Pin1 has a critical neuroprotective role and offers a novel diagnostic and therapeutic target for AD.
Thus , renalase appears to be the possible new marker of these indications in this special population.
Thus , researchers must enhance efforts to ensure that these surveys are guided by the priorities , needs , and concerns of residents.
Thus , researchers traditionally used hormones as tools to induce and examine specific biological effects that are associated with aging.
Thus , ROS and , in particular , NADPH oxidase-derived ROS are a promising therapeutic target for patients with CAA and AD.
Thus ROS generation in neural tissues is a hallmark feature of numerous forms of neural diseases.
Thus , RPL24 K27 acetylation may play a role in ribosome assembly.
Thus , SASPs appear to be beneficial or deleterious , depending on the biological context.
Thus , screening for PPI inhibitors requires enormous number of compounds.
Thus , secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink.
Thus , several factors probably determine the variable effects apoE has on Aβ.
Thus , sex and age differences in displays of aggression were not simple functions of underlying aggressiveness.
Thus , sex and age must be considered as influence factors when using GRASE in a diagnostic manner.
Thus , siRNA induced synthetic lethal RNAi responses have great potential for personalized medicine treatment of cancer.
Thus , SIRT4 is a new component of mitochondrial signaling in the liver and functions as an important regulator of lipid metabolism.
Thus , SIRT7 is a promising pharmacologic target for epigenetic cancer therapy.
Thus , skin and lung aging are linked in carriers of the 2G or 6A allele.
Thus , smoking can contribute to the development of atheromatous renal artery stenosis , which is an aggravating cause of hypertension.
Thus , smoking may affect telomerase activity in the skin , thereby contributing to skin aging.
Thus , some MLBs appeared to have interior protein densities similar to or less than the adjacent cytoplasm whereas others had significantly higher densities.
Thus , source-memory deficits may contribute to older adults ' false memories in real-life eyewitness situations.
Thus , speed and step length can have a large influence on studies investigating age-related differences in required COF.
Thus , stable changes in gene expression upon aging of cell cultures could be caused by changes in their promoter methylation patterns.
Thus , stem cell therapies-characterized by cellular plasticity and the ability to self-renew-may be a promising strategy for aging-related brain disorders.
Thus , stereotype threat can decrease older adults ' false memories , albeit at the cost of fewer veridical memories , as well.
Thus stimulation of vessel growth and / or remodeling has emerged as a new therapeutic option in patients with ischemic diseases.
Thus strategies to maintain cognitive function at an advanced age imply a great challenge to Occupational Medicine.
Thus , subiculum and CA1-2 volumes were associated with speed of acquisition , but not magnitude of gains in virtual maze navigation.
Thus , such approaches may have therapeutic value in counteracting the deleterious effects of aging and protecting the brain against age-associated neurodegenerative processes.
Thus , sustained vascular Notch signaling facilitates metastasis by generating a senescent , pro-inflammatory endothelium.
Thus , SWA might reflect the underlying processes of cortical maturation.
Thus , symmetry and regularity are important indicators of human gait.
Thus , synergistic effect between the @number@ major tau kinases , through these SNPs , appears to determine the risk profile for PD.
Thus , synucleins may function to sustain normal SNARE-complex assembly in a presynaptic terminal during aging.
Thus , systemic manipulations promoting a younger blood composition provide effective strategies to rejuvenate the aged brain.
Thus , takusan-based protein sequences from either mouse or human may be of potential therapeutic benefit in AD.
Thus , targeting molecular mechanisms of aging may be a viable treatment approach.
Thus , targeting NAM-regulated pathways is a promising avenue for developing therapeutics to combat AMD.
Thus , targeting stromal ICAM-1 might constitute a possible therapeutic mean to counteract tumor cell invasion and dissemination.
Thus , targeting TERRA-mediated regulation of telomerase would be a promising therapeutic strategy against cancer and age-associated diseases.
Thus , targeting the ceRNA network involving LINC00858 may be used as a treatment strategy against NSCLC.
Thus , targeting these pathways can abolish age-related bone loss.
Thus , tau hyperphosphorylation per se has a limited impact on olfactory performances in THY-Tau22 mice.
Thus , tau K280 acetylation in our studies was only detected in diseased tissue , suggesting it may have a role in pathological tau transformation.
Thus , T-cell senescence may be more pronounced in older men than women.
Thus , testing with a fast , 6-item constant stimuli protocol is informative , and permits olfactory testing in previously inaccessible research settings.
Thus , the ability to accurately assess cellular maturity and health is important to fully understand immune status and function.
Thus , the ability to encode an association between a stimulus and its initial task-specific response appears to be preserved in aging.
Thus , the ability to preserve the integrity of forensic samples is essential.
Thus , the actions of ginseng are now also linked to LPA and its GPCRs.
Thus , the aged superficial layers appeared to be preferentially vulnerable against Aβ and kainic acid.
Thus , the age-related decline in axonal transport is not an inevitable consequence of either aging neurons or an aging systemic milieu.
Thus , the age-related decline in cognitive functions could be attributable , at least in part , to decrements in GABA inhibitory neurotransmission.
Thus , the agility-dynamic balance test is a promising tool for screening institutionalized older people for risk of FS.
Thus , the aging change of muscle and bone shows a similar change.
Thus , the aim of our study was to examine the effect of aging on sleep-dependent motor memory consolidation in patients with and without OSA.
Thus , the aim of the present work was to validate a version of \ "frailty index \ " for the Italian geriatric community.
Thus , the aim of the study was to compare life-style characteristics and cardiovascular risk factors between regular downhill skiers and the general population.
Thus , the aim of this study was to evaluate the association between physical activity and work ability using both cross sectional and prospective analyses.
Thus , the aim of this study was to explore factors that impact intimate partner relationships for older women with HIV.
Thus , the aim of this study was to investigate how high serum folate and VB12 deficiency could collaboratively aggravate neuronal degeneration.
Thus , the aim of this study was to investigate the effects of lifetime exposure to shiftwork on health impairments and fitness for duty.
Thus the aim was to analyse the validity of time estimates with the Resource Utilization in Dementia ( RUD ) instrument.
Thus , the ameliorated interface interaction led to a homogeneous state of DIOP dispersion in the matrix.
Thus , the authors investigated the association of beta blocker use and CRC risk in a large population-based case-control study ( DACHS study ) .
Thus , the availability of CF EC is paramount to uncover mechanisms of endothelial dysfunction in CF.
Thus , the best treatment for PRT age-related injuries is prevention.
Thus , the cell's capacity to repair its DNA determines the progress of aging , at least in part.
Thus , the cholinergic hypothesis of age-related cognitive dysfunction deserves further consideration as new methodologies for evaluating its validity are increasingly being used.
Thus , the chromatin of cultured lymphocytes from the old-aged individuals underwent modification under the influence of copper and cadmium salts.
Thus , the consequent exploitation of opportunities which are already known is pivotal.
Thus , the crucial societal , scientific and medical challenges for Western societies are to develop and implement measures of primary prevention of dysfunctional aging.
Thus , the current definition for SD , though socially and politically appealing , would be scientifically flawed.
Thus , the CypD-dependent mPTP is directly linked to the cellular and synaptic perturbations observed in the pathogenesis of AD.
Thus , the DAMP Hypothesis is novel and complements other theories that explain the features of ageing.
Thus the decades-long , controlled diminution in athletic performance , should not be seen as a disease process.
Thus , the demands on dysphagia practice are rising.
Thus , the development of lighting systems that preserve the melatonin rhythm could reduce the health risks induced by chronodisruption.
Thus , the difficulty older adults experience in reading is not related to oculomotor control , which appears to be preserved into older age.
Thus , the distinction between lack of initiative and lack of interest seems questionable.
Thus , the easily available human SKPs ( hSKPs ) hold great promises in regenerative medicine.
Thus , the effects of CS on plasma 5HT were consistent between mice and patients with COPD.
Thus , the established ELISA method was RA specific , but its sensitivity was low.
Thus , the FACIT variables are the most powerful indicators for care dependency.
Thus , the famous ( infamous ) Stromboli Cocktail will be brought up to date.
Thus , the fine psychomotor ability \ "aiming \ " is a moderator and predictor for age-related differences in pointing tasks.
Thus the first objective of this study was to assess sensory-dependent knowledge in normal aging using a cross-modal priming paradigm.
Thus , the genetic link is not yet well substantiated that TARDBP mutations can cause the full spectrum of the ALS-FTD continuum.
Thus , the goal of this study was to estimate the excess direct and indirect costs of PD and AP in a national sample.
Thus , the hierarchical mammalian circadian clock provides a unique system to study carcinogenesis as a deregulated physiological process in vivo.
Thus , the identification of new putative pharmacological targets to effectively treat this devastating condition is crucial.
Thus , the imbalance of the increased antioxidant potential , the so-called antioxidative stress , should be as dangerous as well.
Thus , the inflammatory pathway is a potential target for interventions to reduce aging-related disease and disability.
Thus the interaction appears regulated in a cell cycle-dependent manner.
Thus , the interest has been centered on centenarian offspring , healthy elderly people.
Thus , the investigation of oxidative stress across the life span of patients with BD is crucial.
Thus , the involvement of ceramide signaling in quality control gives these findings cellular context.
Thus , the IRE1α-XBP1 pathway is involved in osteoblast differentiation through promoting Osx transcription.
Thus , the irisin precursor ( FNDC5 ) gene is a candidate to influence exceptional longevity ( EL ) , i.e. , being a centenarian.
Thus , their ligands are targets for the treatment of various skin disorders , such as photo-aging and chronological aging of skin.
Thus , their performance could be affected by large inter-subject variations in the data set under registration.
Thus , the isolated pathology and delayed onset of HD may reflect the striatal-selective expression and changes in autophagic activity of Rhes.
Thus , the Klotho protein might function as an anti-aging hormone in mammals.
Thus , the lasting psychological impact of exposure to trauma in childhood might be accompanied by equally enduring changes at the molecular level.
Thus the long-term IWT program is an effective regimen.
Thus , the low serum Klotho levels were associated with increased EFT and CIMT and with the decreased FMD in the study population.
Thus , the magnitude of the difference in BMI between the individuals with the CC and TT + TC genotypes differed by saturated fat.
Thus , the maternal diet is a critical determinant of premature T2D risk.
Thus , the maturation and senescence of neurotransmitter systems have direct implications for lifespan development.
Thus , the means by which the interphase expression pattern is transduced to daughter cells have been unclear.
Thus , the mechanism of re-entry is triggered , and a vicious circle leading to fatal medical-social and social consequences.
Thus , the MeDi in its a priori constructed prototype form may have cognitive benefits in traditional Mediterranean populations.
Thus the method of PRP preparation warrants increased attention.
Thus , the misregulation and / or mutation of FOX genes often induce human genetic diseases , promote cancer or deregulate ageing.
Thus the MND size is far from constant and modulates itself to contribute to the muscle remodeling in various conditions.
Thus the modulation of GABA Impaired immune function has been implicated in the declining health and higher incidence of cancer in the elderly.
Thus , the modulation of sirtuins might be a fruitful approach to reversing the age-related metabolic changes that could underlie tumorigenesis.
Thus , the neurological substrates involved in emotional processing appear to be affected by MCI.
Thus , the Notch pathway is a key regulator of muscle plasticity.
Thus the nucleus remains intact and DNAseIIβ neither gains entry to the nucleus nor degrades the DNA.
Thus , the number of years of shiftwork until the diagnosis of the first reduction in fitness for duty could be calculated.
Thus , the objective of this paper was to analyse the efficacy of case management programs on health care cost , institutionalization and hospitalization.
Thus the objective of this study is to find out how well GPs recognize persons with MCI in their practice population.
Thus , the parameters studied are good markers of the rate of aging , allowing the determination of biological age.
Thus the patients with these problems should pay more attention on nutritional status.
Thus , the physician and consumer need to define exp.
Thus , the physiological process of macroorganism aging can be viewed as a consequence of its microbiological destruction.
Thus , the population burden is likely to increase with future demographic shifts.
Thus the possible association of ITP should be considered when encountering a patient with FS.
Thus , the potential for clinically significant improvements from different interventions is still unclear.
Thus , the potentiation of endogenous copper regulation could be a therapeutic strategy.
Thus , the present study aimed to develop and evaluate a feasible approach for physical activity promotion in the promising primary care setting.
Thus , the present study aimed to evaluate the relationship between sleep and frailty syndrome in residents of long-stay institutions.
Thus , the previously reported serum measures associate independently from each other with skin aging.
Thus , the problems shown in patients with mild DAT in decision making might be related to the patients ' difficulties in predecisional processing.
Thus , the processes of microvascular rarefaction , adult stem cell dysfunction , and inflammation underlie the cycle of physiological decline that we call aging.
Thus , the purpose of the present study was to develop and validate an estimate equation for appendicular skeletal muscle mass using bioelectrical impedance analysis.
Thus , the purpose of this study was to examine the association between UHR performance with biomechanical measures of balance in seniors.
Thus , the purpose of this study was to investigate the possible relationship between strength , aerobic performance , and neuromuscular economy in older men.
Thus , the purpose of this study was to verify whether resistance training could reduce the risk of metabolic syndrome in postmenopausal women.
Thus , the pursuit of life extension and rejuvenation has constituted an inseparable and crucial element in the history of biomedicine.
Thus , the question arises whether obesity is correlated with peripheral indicators of HPA function in adult populations.
Thus , therapeutic strategies that modulate Aβ-induced ER stress through TE could represent a promising approach for the prevention or treatment of AD.
Thus , the ratio of mean intensity of maximal pixels to nuclear area provides a very sensitive morphometric biomarker for the degree of senescence.
Thus , the real prevalence of GERD may well increase with age.
Thus there are mechanisms in place to ensure that mutagenic outcomes of AID activity are specifically restricted to the immunoglobulin loci.
Thus , there are two channels of heredity : informational ( genomic ) and structure-functional ( phenotypic ) .
Thus , the reasons for these dual trends remain opaque and should be explored further.
Thus , there has been considerable emphasis on understanding broadly protective immunological mechanisms for influenza virus.
Thus , there is a critical need for a curative therapy against age-related hypertension , which could greatly decrease the incidence of cardiovascular disorders.
Thus , there is a critical need for new strategies that improve BBB function and limit the development of β-amyloidosis in the cerebral vasculature.
Thus there is a dose-dependent and limited absorption capacity even in healthy individuals.
Thus , there is a great deal of cross-talk between the p53 protein and epigenetic programs.
Thus , there is a lack of consensus as to the suitability of plasma apoE as an AD biomarker.
Thus , there is a need for evaluation of cardiac status of the elderly population.
Thus , there is a need for methods to identify and quantify cellular senescence , both in cultured cells and in vivo.
Thus , there is a need to explore other therapeutic targets to treat BPH / LUTS.
Thus , there is a need to identify new targets to improve treatment of metastatic melanoma.
Thus , there is an unmet need for a validated scale based on actual images.
Thus , there is an urgent need to clarify the molecular mechanisms responsible for this condition in order to identify new biomarkers and therapeutic targets.
Thus there is a pressing need for the development of fertility preservation methods for these individuals.
Thus , there is considerable interest in antioxidant molecules which are able to stabilize membranes because of their protective effects against lipid peroxidation.
Thus , there is international agreement that predictive in vitro methods are needed to increase efficiency of testing and limit the number of animals used.
Thus , there is only limited information available for possible varying silencer activities amongst different hnRNP proteins and composition changes within possible hnRNP complex assemblies.
Thus , there is potential for using IM in the palliative treatment of persons with advanced dementia.
Thus , there is significant interest in the discovery of disease modifying agents.
Thus , the relationship between cognition and insight is expected to differ between younger and older adults with schizophrenia.
Thus , the relationship between snacking frequency and overall dietary quality among adults ( ≥20 years ) will be described.
Thus , the relatively high degree of function among this cohort of hip fracture patients may explain their higher-than-expected vitamin E concentrations.
Thus , there may be opportunities to advance this agenda in creative ways.
Thus the report provides a structural insight to study hHK-1-NK1 interaction that is essential for hHK1 based signaling events.
Thus there should be expectation that future research will reflect the composition of the overall population to determine potential benefits or risks.
Thus , the results of this study may also help explain some of the cellular changes that accompany normal aging.
Thus , there was insufficient evidence to support an age-related deficit in crossmodal attention.
Thus , there was little evidence for different genetic influences on left and right hemisphere regions.
Thus , there was no evidence that specificity of recollected information was reduced in older individuals.
Thus , the role of this protein is still not clearly understood.
Thus , the role of vitamins in adaptation to stressors is evident.
Thus , the SCIT is responsive to the processes that underpin multiple cognitive domains , rather than being specific for a single domain.
Thus , these cells could be a key factor to overcome sarcopenia.
Thus , these compounds possess the potential as pharmacological agents for chemoprevention of human prostate cancer.
Thus , these dietary compounds are receiving significant attention as therapeutic multifunctional cytoprotective agents that simultaneously manipulate various brain targets.
Thus , these findings suggest that HS-1793 has potential as a candidate chemotherapeutic agent against human breast cancer.
Thus , these findings suggest that HS-1793 have potential as a candidate chemotherapeutic agent against human colon cancer.
Thus the selection of appropriate pharmacotherapy for elderly becomes a complex and challenging process.
Thus , these longitudinal findings highlight medial-temporal lobe system integrity as particularly crucial for maintaining episodic-memory functioning in older age.
Thus , these results may explain the specific symptomology associated with cerebellar degeneration in ageing and in cerebellar patients.
Thus , these results point toward a potentially distinct mechanistic and biological role of DNA methylation in dictating the complex aging and disease phenotypes.
Thus these results suggest that the skin's appearance may be enhanced by creating dermal changes through the use of superficially acting treatments.
Thus , these results support HR as valid and readily available parameter in determining AT in healthy elderly men.
Thus , these telomeric factors might be potential clinical biomarkers for early detection or even therapeutic targets of aging and cancer.
Thus , the signaling mechanisms within mitochondria , and between the organelle and its environment , have gained interest as potential drug targets.
Thus , the signaling mechanisms within mitochondria and between the organelle and its environment have gained interest as potential drug targets.
Thus , the simultaneous analysis of abundance and solubility can rationalize the diverse cellular pathologies linked to neurodegenerative diseases and aging.
Thus , the single sex-specific equations were developed using all participants as follows.
Thus , the socioeconomic level seems to affect an important on the survival probability of becoming a centenarian.
Thus , the species-specific PCR analysis of Lactobacillus sp. combined with viable plating data indicates substantial age-related structural differences in the intestinal lactobacilli communities.
Thus , the SPPB has the potential to be used as an early predictor of abnormal pulmonary function in clinical settings and epidemiological study.
Thus , the SPPB has the potential to be used as an early predictor of declining QOL in clinical settings and epidemiological studies.
Thus , the study demonstrates the potential anti-aging and anti-cancer effects of Abisil on senescent and cancer cell lines.
Thus , the study of individual cells in mass culture is necessary in order to properly understand senescence and its associated phenotype.
Thus , the study of the molecular mechanisms of TERRA biogenesis and function may advance the understanding of telomere-related diseases , including cancer and aging.
Thus , the topology of image distribution on the image manifold is always preserved during the groupwise registration.
Thus , the transition of the phenotype towards a slower form cannot be inverted by strength training during the advanced in age.
Thus , the treatment needs will dictate the treatment approach , particularly with injectable filler treatments.
Thus , the treatment objective is to prevent severe dry eye complications via preventing inflammation and apoptosis of the ocular surface cells.
Thus , the understanding of the factors and mechanisms that help to maintain podocytes are of major clinical importance.
Thus , the UPP is an important protein quality control mechanism.
Thus , the use of alfacalcidol might be effective in osteoporotic patients with low muscle mass.
Thus , the use of cross-sectional data under certain assumptions has become a popular alternative.
Thus , the VOCs measurement allowed to discriminate the differences between the age-groups.
Thus , the whole society might suffer from an imbalance between the productive segment of the society and a huge segment of helpless people.
Thus , they are more likely to become injured and present to trauma centers for care.
Thus the years with ADL dependence and mobility limitations are postponed to a higher age and the numbers of these years have decreased.
Thus , they may scavenge free radicals and have an effect on the stratum corneum hydration and epidermal barrier function.
Thus , they provide a comprehensive approach to studying system level brain properties to further our understanding of normal and abnormal brain function.
Thus this article will present speculative arguments of a genetic component contributing to this TBI and PD pathological overlap.
Thus , this raises the possibility that the sensory influence on homeostasis underlies the sensory influence on lifespan.
Thus , this research uses the national survey data ( Community Health Survey ) that was obtained in @number@
Thus , this review aimed to provide a solid overview of the current status and changing patterns of tinea pedis.
Thus , this review highlights the HO-adiponectin-atrial natriuretic peptide axis in renoprotection.
Thus , this review will present the recent updates on the emerging roles of Sirt2-7 members in carcinogenesis.
Thus , this study aims to explore the predictors of quality of life among hospitalized geriatric patients with diabetes mellitus upon discharge in Malaysia.
Thus , this study developed a sensitive assay for analysis of oxidized RNA.
Thus , this study presents one of the largest candidate studies in human genetic longevity research conducted to-date.
Thus , this study provides evidence of the cellular etiology and mechanisms of SGN degeneration in DFNA2.
Thus this study reveals a link between SMAP2 and CALM / syntaxin2 in clathrin-coated vesicle formation from the TGN and subsequent acrosome formation.
Thus , this study shows that intrahemispheric neurofunctional changes in aging also affect the VAN.
Thus , this study suggested the tubulin beta-3 chain has a promising biomarker in skin aging.
Thus , this study suggests that IL-11 is a potential therapeutic target for NRF2-addicted breast cancers.
Thus , this subgroup of skeletal muscle laminopathies that we term the ' Skeletal muscle cluster' , may have a distinct pathological mechanism.
Thus , this treatment modality can be recommended for patients with photoaged skin wishing to improve skin appearance.
Thus , tinted IOLs may protect against the presumed blue-light hazard.
Thus , TMS could be a useful tool in the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia armamentarium of biomarker methods.
Thus , to address the full ageing process , we should include younger populations in ageing research.
Thus , to allow for longtime storage of electroactive nanocellulose-PPy hemodialysis membranes , the degradation of PPy upon storage must be controlled.
Thus , to ascertain the true economic impact of the intervention , the statistical results can be integrated into the budget impact analysis.
Thus , to evaluate LCCSS patients , pain specialists should more carefully investigate the DSCSA than SCCSA.
Thus to help our investigations we aimed to develop a method to identify cells that carry human chromosome @number@ in the Tc1 mouse.
Thus to obtain natural-looking results in facial rejuvenation , the volumetric restoration of these deep compartments should be considered a priority.
Thus , to successfully implement community-wide prevention efforts , it is valuable to assess the level of community readiness to address health issues.
Thus , total daily activity declined almost twice as fast in an individual @number@ years old at baseline versus an individual @number@ years old.
Thus tractive forces are reduced but at the cost of reduced elasticity.
Thus , training elderly to step fast in response to relevant cues may be beneficial in the prevention of falls.
Thus , transcriptome size is an important phenotype in its own right.
Thus , treating patients with symptoms of sleep disorders in the context of psychiatric conditions remains a challenge.
Thus , treatments may fail unless trials target simultaneously all @number@ points in the equation- \ "triple therapy \ ".
Thus , typical development of associative memory was largely explained by age-related differences in CA3-dentate gyrus.
Thus , typical memory tasks engage different regions from typical perception tasks because they inherently test information on opposing ends of this continuum.
Thus , ubiquitination and proteasome degradation of FOXO proteins play an important role in tumorigenesis and represent a viable target for cancer treatment.
Thus , understanding how p63 expression is controlled has biological and clinical importance.
Thus , understanding senescence is crucial for the understanding of organismal biology.
Thus , understanding the complex underlying mechanisms and development of thoughtful , effective strategies that involve these mechanisms are critical.
Thus , understanding the relationship between proteostasis and aging has provided important insights into neurodegeneration.
Thus , understanding the synthetic lethal relationship between p53 mutations and interacting genes in tumor is critical for the personalized treatments of p53 mutant tumors.
Thus , undertaking integrated multifaceted approach is remarkably necessary for reducing the burden of DM and successful TB treatment outcome.
Thus , unemployment may have serious negative implications even for persons retired already.
Thus , urban infrastructure interventions , such as improving public sidewalks , might influence the frequency of elderlies walking in their neighborhoods.
Thus , valid age- and sex-specific reference data should be obtained for each pediatric population living in a particular climate and with a similar lifestyle.
Thus , variations in human telomerase gene that are associated with better maintenance of telomere length may confer healthy aging and exceptional longevity in humans.
Thus , viral delivery of HMGB1 is a candidate approach by which to modify the disease progression of SCA1 even after the onset.
Thus , viscolin may represent a therapeutic candidate for the prevention and treatment of vascular proliferative diseases.
Thus , vitamin D has growingly been involved as a primary determinant of biological modifications and specific clinical conditions.
Thus water-induced wrinkling appears to have no significant impact on tactile driven performance or dexterity in handling wet or dry objects.
Thus , we aimed at establishing a high-performance noninvasive DNA methylation assay based on pyrosequencing for screening of prostate cancer in this article.
Thus , we aimed to clarify this relationship by investigating the relationship between AMS scores and various markers in blood.
Thus , we aimed to investigate the relationship between SampEn and standing balance ability in older adults.
Thus wearable technology has the potential to offer real-time monitoring to provide appropriate nutrition management that is more person-centred to prevent weight loss in dementia.
Thus , we argue that the ability to attend to relevant stimuli and resist capture by salient-but-irrelevant stimuli is preserved with advancing age.
Thus , we assume that mitochondrial involvement is the rule rather than the exception in skin diseases.
Thus , we assume that older men are not at an elevated , and possibly even at a reduced risk to lose bone when immobilized.
Thus , we believe the TTCC shows great potential for use as an AD screening test by a general practitioner in communities worldwide.
Thus , we can hypothesize that the SLC6A3 / DAT1 @number@ bp-VNTR may affect life expectancy in a sex-specific way.
Thus , we compared the performance of healthy participants and AD patients for positive , neutral , and negative faces in such tasks.
Thus , we conclude by arguing that wife sanctification influences widowers ' decisions surrounding remarriage / repartnering.
Thus , we conclude that FXR-Gank-TSPs-Stem cells pathway is a key determinant of liver cancer in animal models and in pediatric liver cancer.
Thus , we conclude that long-term exposure to air pollution is associated with biological aging measures , potentially in a sex-specific manner.
Thus , we conclude that Shh signaling regulates the structure and functional properties of presynaptic terminals of hippocampal neurons.
Thus , we conducted a meta-analysis to summarize the evidence from epidemiological studies of vitamin C and the risk of age-related cataract.
Thus , we demonstrate converging cross-species evidence for training-induced selective plasticity of distractor processing at multiple neural scales , benefitting distractor suppression and cognitive control.
Thus , we developed a novel approach to examine this issue.
Thus , we disclosed a greater than expected complexity of abnormal features of mutated tau isoforms.
Thus , we disclosed an interesting sex difference.
Thus , we employed different systems biology tools to prospect developmental and aging-associated networks for human and murine models for evolutionary comparison.
Thus , we evaluated the add-on effect of cognitive rehabilitation on AD patients under donepezil treatment.
Thus , we focused on the mechanism of the Sirt1-mediated neuroprotective effect that was associated with regulating mitochondrial homeostasis via autophagy.
Thus we further analyzed Tregs expressing or lacking this chemokine receptor.
Thus , we generated induced pluripotent stem cells ( iPSCs ) from affected and unaffected individuals from two families carrying PSEN1 mutations.
Thus we have conclusively demonstrated that CIS arises from epithelium with short telomeres.
Thus , we have demonstrated that Cu's effect on brain Aβ homeostasis depends on whether it is accumulated in the capillaries or in the parenchyma.
Thus , we here identify a therapeutically actionable synthetic lethal interaction between MSH3 and the non-homologous end joining kinase DNA-PKcs.
Thus , we hypothesized a concomitant primary testicular insufficiency.
Thus , we hypothesized that there is a correlation between the results of the Temperament and Character Inventory ( TCI ) and VEGF levels.
Thus , we hypothesize that single-nucleotide polymorphisms ( SNPs ) that may modulate protein phosphorylation could affect osteoporosis risk.
Thus , we hypothesize that with age , the increasing expression of progerin suppresses butyrate-mediated Wnt hyperactivation and apoptosis , leading to increased CRC risk.
Thus , weight should be routinely measured in older adults.
Thus , we introduce a filter structure with micropores onto a glass device to improve permeability to the cell culture space.
Thus , we investigated age-related differences in relationships among empathy and prosocial behavior.
Thus , we investigated ANA associations with all-cause and cause-specific mortality in U.S. adults.
Thus , we investigated BAT and WAT remodelling during ageing in female C57BL / 6 mice.
Thus , we investigated factors that affect CSF lactate levels in neurodegenerative diseases.
Thus , we investigated how age affects EP-related symptoms.
Thus , we investigated this association in community-derived populations.
Thus , we investigate the Chinese aging population in order to demonstrate the process of developing and using user profile and persona.
Thus , we manipulated inter-stimulus intervals ( ISI ) and assessed executive functions.
Thus , we must identify novel targets for anti-angiogenic agents to sustain inhibition of angiogenesis for tumour therapy.
Thus , we need a specific strategy for treatment for malignant neoplasms in the elderly.
Thus we need better fracture predictors in men.
Thus , we observed a higher expression for collagen and IGF1 mRNA in local musculotendinous tissue in ACRO patients relative to GHD patients.
Thus , we profiled cellular bioenergetics of human coronary artery smooth muscle cells and effects of metabolic intervention.
Thus , we proposed the potential of H2 for preventive and therapeutic applications.
Thus , we propose that cognitive reserve may account for bilateral engagement efficiency.
Thus , we propose that proprioceptive recalibration combines with adapted sensorimotor mappings to produce changes in reaching movements.
Thus , we provide normative data for age and gender.
Thus , we recommend using the WHO classification of hearing loss strictly and including standard audiometric measures in population-based health surveys.
Thus , we retrospectively analyzed the clinical features of @number@ male and @number@ female patients with bladder tamponade.
Thus , we searched for cellular and molecular mechanisms that might account for this distinct memory response.
Thus , we sought to elucidate relations of pulse pressure with aortic stiffness and aortic and cardiac dimensions.
Thus , we sought to examine the association between cognitive function and salivary cortisol levels in a representative sample of older men and women.
Thus , we sought to synthesize the existing body of evidence and offer a perspective on how to integrate frailty into clinical practice.
Thus , we speculate that the melatonin-synthesizing actions of the engulfed bacteria were retained when these organelles became mitochondria and chloroplasts , respectively.
Thus , we studied \ "whole-life \ " inorganic arsenic carcinogenesis in mice at levels more relevant to humans.
Thus , we succeeded in establishing iPSC clones from TIG-1.
Thus , we successfully visualized healthy aged kidneys on 3D images and confirmed the underlying pathology.
Thus , we suggest that basic motions can elicit changes in emotional manner in childhood to perceptive and executive processes according to their specific trajectory.
Thus , we tested the association of CONTROLS : Only BACKGROUND : Clostridium difficile is the most common cause of infectious diarrhea in hospitalized patients.
Thus we tested the hypothesis that acute dietary nitrate supplementation increases the compensatory vasodilator response to hypoxic exercise , particularly in older adults.
Thus , we will be able to study more accurately the experience of young adults facing cancer and the associated psychological side effects.
Thus , when the Fanconi anemia pathway is defective , WRN helicase inhibition perturbs the normal ICL response , leading to NHEJ activation.
Thus , while respiratory manifestations dominate much of cystic fibrosis ( CF ) care , there are prominent multi-organ manifestations and comorbidities.
Thus , whole-exome resequencing establishes an efficient , noninvasive approach towards early detection and causation-based diagnosis of rare kidney diseases.
Thus , wide variation in the prevalence of sarcopenia has been reported , generally ranging up to @percent@ for men and @percent@ for women.
Thus , with increasing age , human hematopoietic stem / progenitor cells undergo quantitative changes as well as functional modifications.
Thus , with the aging of the population , the mechanism-based therapeutics for AD is desperately needed.
Thus , women maintain a verbal memory advantage over men in aMCI despite similar levels of AD pathology.
Thus , WS-CoQ10 as inhibitor of SIPS and ameliorator of autophagy could be an effective prophylactic / therapeutic agent for AD.
Thus , Wt1 is an important regulator of cancer growth via modulation of tumour vascularization , immune response and metastasis formation.
Thus , yeast chromatin is a favourable environment to evaluate , inhibit or activate an ectopic histone deacetylase activity in an in vivo substrate.
THV for this purpose.
Thymic atrophy is often associated with ageing.
Thymic involution during aging is a major reason for the decreased production of naive T cells and reduced immunity.
Thymic naïve CD4 + T cells may provide a biomarker for vaccine responsiveness in elderly cohorts.
Thymi from aged Tbata-deficient mice are larger and contain more dividing TECs than wild-type littermate controls.
Thymi with diminished function contain fewer stromal cells , whereas thymi with robust function contain proliferating stromal cell populations.
Thymulin is a thymic hormone exclusively produced by the epithelial cells of the thymus.
Thymus has a unique appearance at ultrasound ( US ) .
Thymus involution has a significant effect on the immune system , as it signals the onset of immune aging and decline in function.
Thymus involution provides a direct link between the endocrine and immune systems and warrants further study in marsupials and monotremes.
Thyroglobulin antibody ( TgAb ) and thyroid peroxidase antibody ( TPOAb ) are diagnostic hallmarks of HT.
Thyroid carcinoma is the most common endocrine malignancy.
Thyroid cartilages from glutaraldehyde-perfused male minipigs and from domestic pigs were used for X-ray , light microscopic , and transmission electron microscopic analyses.
Thyroid dysfunction increases with age , so changes in THs levels in the elderly could be a factor affecting the development of neurodegenerative diseases.
Thyroid dysfunction is common in the general population especially in women.
Thyroid function and the gonadal axes are related throughout the woman's fertile period.
Thyroid function tests , cortisol , glucose , insulin and biochemical parameters were measured.
Thyroid hormones ( THs ) are a major factor controlling metabolic and respiratory rates in virtually all cell types in mammals.
Thyroid stimulating hormone ( TSH ) , free triiodothyronine ( FT3 ) , and free thyroxine ( FT4 ) were measured to evaluate thyroid status.
Thyroid-stimulating hormone ( TSH ) level increases with aging , and hypothyroidism is highly prevalent in CKD patients.
Thyroid supplementation accelerates mitochondrial oxygen consumption and oxidative stress , whereas a redox-modulator therapy is advisable , given the long-lasting treatment in such cases.
TIA-1 ( T-cell restricted intracellular antigen-1 ) is an RNA-binding protein involved in splicing and translational repression.
TIADL performance improved in those with higher HIV viral load , poorer medication adherence , and poor executive functioning.
Tibetan macaques ( Macaca thibetana ) , also known as Chinese stump-tailed macaques , are a threatened primate species.
Tibia and patella bone lead levels were measured using K-x-ray fluorescence.
Tibial and radial cortical areas , thicknesses , and BMD were significantly higher in cases.
Ticagrelor also reduced all-cause mortality relative to clopidogrel , although statistical significance of this was not confirmed in hierarchical testing.
Ticagrelor has a faster onset of action and provides greater inhibition of platelet aggregation than clopidogrel.
Ticagrelor was generally well tolerated and was not associated with an increased risk of major bleeding relative to clopidogrel.
Tick-transmitted spotted fever group Rickettsiae ( SFGR ) are considered emerging disease pathogens in Europe.
TICV and WMLs were rated on computerized tomography.
TICV , APOE , and other potential mediator / moderator variables are discussed in the context of the brain reserve hypothesis.
TICV did not modify the odds of dementia in those with the apolipoprotein e4 phenotype.
Tidal flow-volume loops were recorded during the incremental exercise test with maximal flow-volume loops measured pre- and post-exercise.
TI decrease , CR Prostatic carcinoma is the second commonest cancer in males and is so common as to become almost holoendemic with advancing age.
TIF1γ was almost undetectable in leukemic cells of @percent@ of CMML patients.
TIF graphs showed adequate informational value to permit inferences about groups for @number@ subscales ( Relationship , Cooperation , and Access / Coordination ) .
Tight coupling of reproduction to environmental factors and physiological status is key to long-term species survival.
Till date , mitochondrial stress and toxins remain the most potent inducers of mitophagy.
Till date , \ "super p53 \ " mutants exhibiting more potent ability to induce apoptosis than wild-type p53 have been reported.
Tilt tests and carotid sinus massage ( CSM ) were performed in accordance with best practice guidelines.
Time and density dependent ichthyotoxicity to Lateolabrax maculates juveniles was also detected.
Time and frequency domain variables were derived including the HRV index.
Time-based prospective memory ( TBPM ) is required when it is necessary to remember to perform an action at a specific future point in time.
Time-by-gender interaction was significant , as were the main effects of gender and BMI classification.
Time course experiments in both cell lines suggest that the @number@ kDa and @number@ kDa SMP30 forms are likely generated from the @number@ kDa SMP30.
Time-dependent Cox regression analyses were used to estimate spousal loss-related mortality by causes.
Time-dependent Cox regression was used to model the association between weight loss and gain causes and subsequent 3-year mortality.
Time-dependent leukocyte density and diversity and the magnitude of myocardial injury is responsible for the resolving and nonresolving pathway in myocardial healing.
Time domain and spectral analysis of heart rate variability ( HRV ) quantified autonomic cardiac regulation.
Time-domain-dependent body sway variables were calculated.
Timed up-and-go , @number@ times sit-to-stand , and step test were also assessed , and lower limb strength was measured.
Timed Up and Go results were grouped as fast ≤ @number@ seconds , intermediate = 11-14 seconds , and slow ≥ @number@ seconds.
Timed up-and-go test can be performed quickly and is able to predict the likelihood of fall.
Time Frame @number@ excluded a 7-week period following the earthquake in order to account for deaths due to trauma.
Time-frequency analyses conducted at source level found variations in both θ and γ ranges across age.
Time-frequency analysis of the data was performed and phase-locking index , evoked amplitude and total intensity measures were extracted and decomposed by non-negative multi-way factorization.
Time has come for designing and developing human studies with those candidate therapies showing most promising benefits and least potential toxicities to treat age-related diseases.
TIME HORIZON : @number@ years.
Time in therapeutic range ( TTR ) was computed according to Rosendaal's method.
Time-invariant covariates were age , working status , diabetes and cigarette-years.
Timely access to information was also important , especially for people without the support of emergency or crisis management teams.
Timely detection and treatment reduces fracture risk and particular attention should be drawn to age.
Timely initiation of ART in HIV-infected individuals dramatically reduces mortality and improves employment rates to levels prior to HIV infection.
Timely nutritional assessments by health professionals are needed to identify older men at nutritional risk.
Timely recognition of lack of driving confidence might allow for appropriately targeted intervention strategies and prevent premature driving cessation.
Timely treatment for CKD is necessary to minimize costs for unnecessary care and testing.
Timely updated , comprehensive , and systematic introduction of ALT activity is necessary to aid clinicians make better use of this enzyme.
Time marks , gathered at three standardised sectors , served as the performance variable.
Time of death was obtained , providing a maximum survival time of @time@ ( initial evaluation took place between @number@ and @number@ ) .
Time-Of-Flight magnetic resonance angiographic images were transported to a central lab and analyzed blind to obtain the clinical data.
Time- or age-dependent accumulation of mitochondrial damage and dysfunction is strongly associated with aging [ @number@ ] .
Time performing moderate to vigorous intensity physical activity did not modify these associations.
Time-pressured staff may struggle to provide mealtime assistance.
Time-series microarrays were performed on mouse cartilage tissue to identify genes expressed in a circadian manner.
Time since HIV diagnosis and sexual orientation were primary variables for which differences were observed.
Time since HIV diagnosis was positively associated with mastery whereas victimization was negatively associated with mastery.
Time since injury demonstrated an inverse relationship with both social disconnectedness and perceived isolation.
Time spent away from home did not significantly differ between the glaucoma subjects and suspects ( p = @number@ ) .
Time spent in moderate-and-vigorous physical activity ( MVPA ) was also assessed by questionnaire and accelerometer.
Time spent on course attendance can be interpreted as an adherence indicator that makes a difference for various cognitive outcomes of the intervention.
Time spent on watching TV , reading , using computers or playing games after work was also calculated.
Time spent outdoors or indoors was not significantly associated with CT-related parameter in multivariate analysis.
Time spent outside was recorded.
Time spent sedentary and in light intensity activity were assessed using an accelerometer worn for 3-7 days ( Actigraph GT3X ) and by self-report.
Time spent walking decreased on average by @percent@ annually from year @number@ to year @number@
Time spent watching television was positively associated with BMI , while reading and computer use were not.
Times to lower gait speed and cognitive function did not precede each other ( P = 0.91 ) .
Time taken to use each HAS from fastest to slowest was : stairs , the ARISE , ramp , PL and stair glide.
Time to admission was @number@ h and mean time taken to be reviewed by an integrated care manager was @number@ h.
Time to complete the ten-repetition chair stand decreased significantly ( @percent@ , P = @number@ ) .
Time-to-death ( TTD ) has commonly been used to project LTCE because it was a better predictor than age.
Time-to-death was examined as an alternative time metric to chronological age , as it may better represent biological constraints.
Time to death within @number@ year after the community survey was determined from Centers for Medicare and Medicaid Services vital statistics records.
Time to diagnosis of AF was the primary outcome measure.
Time to extubation using a cut-off at @number@ hours was assessed.
Time to first episode of AT / AF > 1 min was not significantly different between the groups ( P = .9 ) .
Time to functional disability was the age at midpoint between the first occurrence of disability onset in the survey year and prior survey year.
Time-to-theatre ( TTT ) is a key performance indicator of theatre efficiency.
Time to the first fall after inclusion and number of falls in the first year after inclusion were the primary endpoints.
Time to walk while performing @number@ cognitive tasks was measured.
Time trends of suboptimal prescribing in older , community dwellers have been poorly investigated , particularly in Italy.
Time trends were assessed with Prais-Winsten regression models.
Time-varying associations should be considered in future studies of smoking behavior , TL , aging , and disease risk.
Time-varying estimates of the autoregulation index [ ARI ( t ) ] were obtained with an autoregressive-moving average model with coefficients expanded by orthogonal decomposition.
Time-varying health , social , and lifestyle factors account for some of these patterns.
Time-varying low-calorie sweetener use was operationalized as the proportion of visits since baseline at which low-calorie sweetener use was reported.
Time-varying models produced stronger , more robust estimates than models using a single measurement of physical activity at baseline.
Time-window analyses did not reveal any clear induction-latency pattern.
TIM has been a target in the search for chemical compounds against infectious diseases and is a model to study catalytic features.
Timing of feeding and fasting strongly affects daily rhythms in the expression of circadian clock genes and key regulators of nutrient homeostasis.
TIM is one of the most studied enzymes with more than @number@ structures deposited in the PDB.
TIM is responsible for obtaining net ATP from glycolysis and producing an extra pyruvate molecule for each glucose molecule , under aerobic and anaerobic conditions.
Tinea corporis was common in the third decade.
Tinea or dermatophytoses are of skin superficial and fungous infections affecting keratinized tissues such as hair , nail , and superficial layer of epidermis.
Tinnitus is a widespread auditory disorder affecting approximately 10-15% of the population , often with debilitating consequences.
Tint and Trec were monitored throughout the TT.
Tips for initiating end of life discussions with patients and families utilising the ' PREPARED ' acronym , and ensuring appropriate care delivery are included.
TIP was measured through the Trust in Physician scale from Anderson and Dedrick ( Anderson LA , Dedrick RF.
Tissue and organ rejuvenation and senescence / aging are closely related to the function of stem cells.
Tissue blocks were then processed and embedded in wax.
Tissue Doppler analysis revealed increased Aa velocity , decreased in Ea / Aa ratio and IVRT.
Tissue engineering is really a new hope for future medicine.
Tissue engineering technology has also been introduced and opened a new venue of opportunities in this field.
Tissue factor ( TF ) is the primary initiator of blood coagulation.
Tissue from the BBDP has contributed to more than @number@ publications and more than @number@ grant-funded projects.
Tissue homeostasis and regenerative capacity are nowadays considered to be related to the stem cell pool present in every tissue.
Tissue homeostasis and regenerative capacity rely on rare populations of somatic stem cells endowed with the potential to self-renew and differentiate.
Tissue homeostasis declines with age partly because stem / progenitor cells fail to self-renew or differentiate.
Tissue iron deposited in ferritin molecules can be measured in vivo with magnetic resonance imaging utilizing the field-dependent relaxation rate increase ( FDRI ) method.
Tissue loss mapped to amygdalo-hippocampal subregions known to have bidirectional and specific connections with frontal cortical and limbic structures and was related to clinical severity.
Tissue mechanical and structural properties were characterized by planar biaxial mechanical testing and histological methods.
Tissue physiology is profoundly influenced by the distinctive organizations of cells in organs and tissues.
Tissue plasminogen activator ( tPA ) is the only available treatment for acute stroke.
Tissue properties did not differ ( p > 0.05 ) between the left and right ureter.
Tissue regeneration is impaired in aged individuals.
Tissue repair after injury is a complex , metabolically demanding process.
Tissue samples from @number@ high-grade tumors , @number@ low-grade tumors and @number@ normal brain cortices were analyzed by 2D-PAGE and proteomic profiling by mass spectrometry.
Tissue samples were immunomarked for collagen IV and smooth muscle actin.
Tissue sampling was performed @number@ @number@ @number@ and @number@ days after surgical de-tensioning of the tendon construct.
Tissues and organs change over time , regulated by intrinsic ( genetic ) determinants and environmental ( and microenvironmental ) adaptation.
Tissue sections were assessed by light microscopy and quantified by threshold analysis of digital images and stereological analysis using the Space Balls probe.
Tissue shrinkage is also not an issue , since the estimates provided are independent of tissue volume.
Tissue slices were immunohistochemically stained with monoclonal anti-LH antibody and polyclonal anti-S100 antibody for the detection of LH and FS cells , respectively.
Tissue-specific age CGs are frequently located outside CpG islands with decreased methylation , and common ageCGs show the opposite trend.
Tissue-specific insulin sensitivity was measured with clamps combined with stable isotopes.
Tissue-specific miRNA profiles associated with senescence have been described for several cell and tissue types.
Tissue specific somatic mutations occurring in the mtDNA control region have been proposed to provide a survival advantage.
Tissue specimens must be carefully age-matched when studying ICC in disease.
Tissue specimens were routinely prepared for histological and morphometric analysis.
Tissues that elaborate higher GLB1 display increased uniformity of expression.
Tissue structure was analyzed via histological techniques.
Tissues were imaged on a spinning-disk fluorescence microscope and a high-resolution structured illumination microscope.
Tissue tensile stiffness was determined for annulus and cusp regions using a half-space punch model.
Titanium alloys have superior corrosion resistance than stainless steel.
Titles and abstracts were reviewed and publications were screened by both authors independently to exclude articles that did not satisfy the inclusion criteria.
Titles were screened and non-English , duplicate or irrelevant entries were excluded.
Tk has been calculated as index of red blood cell rigidity.
TL1A and DR3 may play an important role in the pathophysiological process of the aged bladder.
TL and motor and cognitive performance were assessed at baseline ( diagnosis ) and repeatedly up to three to five years follow up.
TL did not show any statically significant difference , only hg W had slightly longer telomeres among others.
TLE for females at age @number@ was highest for Chileans ( @number@ years ) and lowest for Brazilians ( @number@ years ) .
TLE patients and older adults , both having deficits in episodic memory , provided fewer steps relevant to the given solution than their comparison group.
TL measurement alone is not a good marker for predicting cancer risk in A-T families.
TL measurements across panels were standardized by z-transformation.
TLR2 and TLR4 expressions were unchanged.
TLR2 gene might not play a major role in the genetic predisposition to late-onset Alzheimer's disease in this population.
TLR2 up-regulation on activated microglia / macrophages resulted in astrocyte activation and marked up-regulation of cytokines / chemokines.
TLR2 up-regulation on microglia / macrophages coincided with morphological changes consistent with activation at @number@ and @number@ weeks of age.
TLR4 KO mice on a high-fat and high-sugar diet consumed less food and drink , resulting in diminished weight gain.
TLR7 stimulation up-regulated T-bet in all B cell subsets from young and elderly individuals , and more in the elderly.
Tlusty's topological rate distortion analysis of the genetic code is applied to protein symmetries and protein folding rates.
TL was analyzed by monochrome multiplex quantitative polymerase chain reaction.
TL was analyzed by quantitative PCR in total human genomic DNA isolated from paired subcutaneous and visceral AT of @number@ lean and @number@ obese individuals.
TL was measured by Southern blotting from DNA samples extracted from white blood cells.
T lymphocytes are essential mediators of immunity that are produced by the thymus in proportion to its size.
T manipulations did not significantly affect visual recognition memory , working memory , reference memory or fine motor function at any age.
TM area and length were not correlated with age.
TMD incidence was positively associated with age but weakly associated with gender , thereby differing from demographic patterns of prevalence found in some cross-sectional studies.
TMD incidence was positively associated with age , whereas females had only slightly greater incidence than males.
TMEM106B genotyping was carried out , and years of education recorded.
TMEM230 gene mutations have been reported to be linked with Parkinson's disease ( PD ) recently.
TMF reduced the risk of aspiration seen on videofluoroscopy but not clinical aspiration and pneumonia.
TMF was associated with lower daily energy and fluid intake and variable adherence.
TMM was estimated from an ultrasound-derived prediction equation.
TMS was delivered at @percent@ of resting motor threshold randomly in @number@ ms increments between @number@ and @number@ ms after the tone.
TMT-B but not the free recall tests were a significant predictor ( AUC = @percent@ ( @percent@ CI = @percent@ , @percent@ ) ) .
TMT-B score and difference score were correlated with gray matter volume ( GMV ) of inferior frontal gyrus , precuneus and superior temporal cortex.
TMT was related to contrast sensitivity , motion direction , orientation discrimination , working memory , verbal fluency , and literacy.
TMV was not associated with any of these parameters.
TMZ degradation time in the tumor core was found to increase from @number@ to @number@ hours.
TNAP inhibitors , discussed extensively in this book , are in development to prevent pathological arterial calcification.
TNF inhibitors may be an useful tools for management of active RA resistant to conventional DMARDs in women who desire to bear children.
TNF is an inflammatory cytokine that upon binding to its receptor , TNFR1 , can drive cytokine production , cell survival , or cell death.
TNFα and IL-10 secretions were increased following HF but IL-8 secretion was decreased.
TNFα and IL-1β paralyzed growth cone motility and induced growth cone collapse in a dose-dependent manner reflected by complete attenuation of neurite outgrowth.
TNFα and IL-1β provoked rapid , NOX-mediated generation of ROS in advancing growth cones , which preceded paralysis of motility and collapse of morphology.
TNF-α and IL-6 levels were significantly correlated with depressive symptoms , and adjustment for depression reduced the group effect for both.
TNF-α had no significant effect on epidermal apoptosis.
TNF-α increased production ( p < 0.01 ) , tissue levels ( p < 0.005 ) and catalytic activity of the endogenous MMP-1 activator MMP-3.
TNF-α increased secretion of MMP-1 ( p < 0.01 ) but had no impact on MMP-1 quantities in the tissue.
TNFα-induced activation of NF-κB was suppressed in ARHGAP18-induced senescent EC , and this inhibition was reversed by Caveolin-1 knock-down.
TNF-α-induced expression of p21 was inhibited from @number@ to @percent@ , by DTD serum in a concentration-dependent manner.
TNFα modulated α-synuclein proteostasis but was not modified by the LRRK2 mutations in this paradigm.
TNF-α serum concentrations progressively increased with age.
TNS fluorescent measurement demonstrated the decrease of hydrophobicity in the glycated albumin.
To accommodate the medical care demand changes , it is necessary to secure a system for providing medical care.
To accomplish this , a better understanding of disease mechanisms is needed.
To accomplish this , @number@ normal dogs underwent MRI of the brain at various times after birth from @number@ to @number@ weeks.
To account for children uninsured or in the Vaccines for Children program , estimates were projected using National Immunization Survey coverage data.
To account for cultural and welfare state characteristics , cross-national studies ought to be undertaken.
To account for heterogeneity between surveys , we used meta-analyses to study time trends.
To account for these characteristic patterns , a thiyl radical-based molecular mechanism of intramembrane hydrophobic cross-linking is discussed.
To achieve a lifespan beyond the longevity of individual cell types , tissue-specific stem cells sustain these tissues throughout the life of a human.
To achieve an adequate sample size to detect these common variants , large , international collaborations have formed.
To achieve better compensation for age-related changes in cognition , we need to understand their brain substrates , telling cognitively relevant from epiphenomenal.
To achieve complete repair and regeneration it is necessary to recapitulate the developmental process with complete formation of cementum , bone and periodontal ligament fibers.
To achieve earlier detection or prevention of undernutrition , more information is needed about risk factors for the development of undernutrition in community-dwelling older individuals.
To achieve effective health communication in varying cultural contexts , an empirically and theoretically based understanding of culture will be indispensable.
To achieve expression similar to human patients , the mutation is expressed in flies carrying one copy of the wild type synaptotagmin gene.
To achieve recommended protein intakes , the panel strongly urges consumption of high-quality protein-containing whole foods.
To achieve successful gene therapy , a gene delivery system is necessary to overcome several barriers in the extracellular and intracellular spaces.
To achieve the patient's desired result , surgeons use various techniques , either in isolation or in combination.
To achieve these goals requires concerted efforts of a collaborative network of academic , community , and public health organizational partnerships.
To achieve this goal , our group has developed a wearable gas monitor with a complete sensor fabrication and calibration protocol for free-living conditions.
To achieve this goal , surgery is usually required for the vast majority of hip fracture patients.
To achieve this , health professionals , religious leaders and policy makers need to work together.
To achieve this , increased interventions will be required for a large number of sites and species.
To achieve this study , slot-blot techniques , for protein and mRNA , as well as immunohistochemistry and hybridohistochemistry methods , were used.
To achieve this , the biological impact of CHIP variants on HSC function must be validated.
To achieve this , we normalize the data across subjects by matching the standing up and lying down portions of triaxial accelerometry data.
To achieve this , we used a subset of our sample , for which TL data was available , to identify a suitable instrumental variable.
To achieve this , we use environmentally placed sensors for non-intrusive monitoring of human behaviour.
To add , MM-CGI-50 can be effectively used to assess grief in Polish family caregivers of AD patients.
To address health inequities , researchers , communities and funders may need to increase awareness of these approaches and plan accordingly.
To address knowledge gaps , raise awareness , and disseminate best practice , we reviewed recent data and guidelines on HZ from the Asia-Pacific region.
To address the aforementioned issues , mobile agents are adopted.
To address the challenge of early diagnosis , we use CBA mice to analyze the initial stages and functional onset biomarkers of ARHL.
To address the concerns , we developed a spatial random-effects JPM for county-level cancer incidence data.
To address the current inadequate management of pain in dementia , a comprehensive approach is needed.
To address the question , we asked older and younger adults to perform a task while a task-irrelevant feature was merely exposed.
To address the role of FOXO3 in PD , we modulate its activity in dopaminergic neurons overexpressing human α-synuclein.
To address the role of the hormonal dysregulation to mobility-disability , we start to discuss the contribution of the single hormonal derangement.
To address these challenges we devised ModuleBlast , which uses both expression and network topology to search for highly relevant sub-networks.
To address these deficiencies , we estimated educational differences in disability-free life expectancy for eight countries from all parts of Europe in the early 2000s.
To address these issues , studies examining the effects of ED on EI or body weight in nonelderly adults were reviewed.
To address these issues , we evaluated macrophages derived from peripheral blood monocytes of nvAMD patients and age-matched controls.
To address these issues , we generated transgenic mice that permit conditional p16 expression.
To address these issues , we propose a mesh-to-volume registration approach , characterized by a progressive model deformation.
To address these limitations , we created a new brief cognitive assessment tool : the Sweet @number@
To address these limitations , we developed a fully automated , unsupervised segmentation method for basal ganglia T2 w hypointensities.
To address these questions , we measured leukocyte telomere length ( LTL ) in male participants from the Zutphen Elderly Study.
To address this , a community sample of @number@ children completed the SRET and a depressive symptoms measure at ages @number@ and @number@
To address this aim , cognitive interviewing techniques were used during face-to-face semistructured interviews with @number@ adults age 65-89 years.
To address this gap we tested the efficacy of a conversation-based ToM training with age-appropriate ToM tasks and its transfer effects on metamemory.
To address this gap , we undertook a scoping review to enhance understanding of resident-to-resident abuse in LTC homes.
To address this important issue a dual arc stimulus was developed that samples sensitivity recovery in two retinal locations.
To address this issue , the alignment and location of the two eyes ' fixations during reading were monitored for young and older adults.
To address this issue , we conducted an investigation of the National Social Life , Health , and Aging Project ( NSHAP ) cohort.
To address this issue , we induced liver fibrosis by carbon tetrachloride ( CCl ( @number@ ) ) chronic administration to 8-week- and 15-month-old mice.
To address this issue we performed microarray-based microRNA expression analyses.
To address this issue , we propose that Congress instruct the Centers for Medicare and Medicaid Services to collect ADs from Medicare beneficiaries.
To address this problem , we propose a Smarter Safer Home solution that enables ageing Australians to live independently longer in their own homes.
To address this question , we have examined the fibre type composition of the human masseter , a jaw closing muscle , at young age.
To address this question , we have incorporated prospective neuroimaging and neurologic assessments as measures in subsequent studies involving children with HGPS.
To address this question , we used Western blotting of postmortem tissue from human @date@ female , @number@ male ) covering a range of ages.
To address this , we examined younger and older adults ' performance in a motion detection task.
To address this , we introduce algorithms that quantify local nucleosome-scale conservation of PcG-region topology.
To address this , we investigated the interaction of swim-training status and maturity on cardiovascular and metabolic responses to lower and upper body exercise.
To address this , we will conduct a systematic review and meta-analysis of elder abuse prevalence studies from around the world.
To address whether GDF8 and GDF11 are functionally identical , we compared their signaling and structural properties.
To adequately perform perioral rejuvenation procedures , it is necessary to understand the morphologic changes caused by facial aging.
To adjust for within-subject dependence over repeated assessments , multiple linear regression with generalized estimating equation methods was used.
To advance the translation of neuroplasticity research towards clinical applications , the National Institutes of Health Blueprint for Neuroscience Research sponsored a workshop in @number@
To \ "age \ " the clots , serum was replaced by fresh blood periodically.
To a large extent , these processes are influenced by alterations affecting the integrity of genome architecture and , ultimately , its phenotypic expression.
To a lesser degree , the experts also recognised alternative characteristics and behaviours , including people with disabilities and those who struggle financially.
To alleviate the stress and restore homeostasis , the ER activates a signaling network called the unfolded protein response ( UPR ) .
To ameliorate this issue , granularity reduction is commonly performed by applying isotropic spatial filtering.
To analyse SR-WBV effects Wilcoxon signed-ranked tests were used.
To analyze the BMI distribution , the two groups were subgrouped by age with 5-year interval.
To analyze the data SPSS- @number@ Software was used for descriptive and analytical statistics.
To answer these questions , globin extracted from the DBS cards was analyzed , and the stability of the modifications was evaluated.
To appreciate its capacity during aging and to elucidate its impact on parenchymal integrity we undertook a correlation using ultrasonography and brain MRI.
To approach the issue , @number@ in-depth interviews were conducted in Marseille in @number@
To ascertain ALC1's role in BER in mammalian cells , we disrupted the ALC1 gene in human TK6 cells.
To assert relationships , the individual images in the MALDI imaging datasets were correlated with lipofuscin fluorescence recorded from the same tissues following proper registration.
To assess acceptability , patients were interviewed , discussion were held with the involved physical therapists was held , and health records were studied.
To assess cardiac autonomic function , HRV was obtained with the MemCalc / Chiram software program after Holter ECG.
To assess differences in outcomes , a repeated measures general linear model was used , controlling for agency and baseline general health.
To assess for mediation , the statistical analyses were carried out following the procedure described by Baron and Kenny.
To assess lipid peroxidation , we measured plasma levels of lipid hydroperoxide ( LPH ) and 4-hydroxynonenal ( 4-HNE ) using spectrophotometric assays.
To assess our paradigm , we first tested for the psychometric criterion of repeatability , and report that our metrics are reliable across repeated sessions.
To assess physical functions , we measured handgrip strength , knee extension strength , standing balance and walking speed.
To assess protein oxidation , we measured the plasma levels of protein carbonyl ( PC ) and 3-nitrotyrosine ( 3-NT ) using the ELISA technique.
To assess publication bias Egger's test was applied.
To assess publication bias Egger's test was used.
To assess reproducibility of the measured hippocampal volume change , both back-to-back ( BTB ) MPRAGE scans available for each visit were analyzed.
To assess studies that evaluate the relation between serum thyrotropin concentration , very old subjects , and their events.
To assess the association between edentulism and the independent variables , a bivariate analysis was carried out.
To assess the correlation between sociodemographic characteristics and cognitive functions , the early and delayed responders completed the same questionnaires and neuropsychological tests.
To assess the effect of functional tight junctions , stratified cultures of polarity regulator partitioning-defective-3- or E-cadherin-deficient keratinocytes were infected.
To assess the effects of age and menopause , we evaluated retrospectively a therapeutic drug-monitoring database.
To assess the effects of study design variables , we used meta regression models.
To assess the influence of expertise , we considered precision mechanics as experts in fine motor control.
To assess their bodies ( in ) adequacies , they engaged in upward or downward social comparisons with others their age.
To assess the prognostic value of TB in pT1 CRCs , this meta-analysis evaluated @number@ studies involving a total of @number@ patients.
To assess the risk of patients the Duke's indicator was used.
To assess the significance of differences between the results obtained in the test with eyes open and without visual control the Wilcoxon test was used.
To assess this issue , the authors conducted focus groups with nurses and nurse managers.
To assess this relationship , samples from two groups of subjects were used.
To assess this , we constructed chimeric H-1 viruses expressing Kilham rat virus ( KRV ) capsid proteins , in their complete or partial forms.
To assess voting conditions in long-term care settings , we conducted a multicenter survey after the @number@ European elections in France.
To assess well-being , the UCLA Loneliness Scale-8 was used.
To assist basic research on aging , a comprehensive database and analysis platform for aging-related genes is required.
To assist in this process , this article provides an overview of common comorbidities affecting HIV-infected persons and provides practical guidance on their management.
To assist investigators in making design choices , we modeled Alzheimer's disease prevention clinical trials.
To avert these dangers , cells have developed powerful quality control strategies that counteract protein damage in a compartment-specific way.
To avoid e-cigarette use for initiation to nicotine addiction , messages targeting youth and women should be prohibited.
To avoid over fitting , the training is based on the leave-one-out principle.
To avoid potential confounding variables with use of tetracycline-inducible CA9 knockdown , we established CA9-ko and NHE1 / CA9-dko cells.
To avoid the potentially devastating outcomes , appropriate diagnostic procedures , antibiotic and surgical treatment , and appropriate follow-up are required.
To avoid this catastrophic cycle , lactate dehydrogenase is upregulated at the expense of lactic acid acidosis.
To avoid undergoing carcinogenesis in response to oxidative stress , cells trigger a succession of checkpoint responses , including premature senescence and apoptosis.
To avoid wrongly designating children at risk for AO , we propose a cut-off with a high specificity at the risk of approximately @number@
Tobacco control policies that reduce SHS exposure could have an impact on reducing healthcare costs in China.
Tobacco smoke exposure at various periods , other lifestyle and sociodemographic factors were ascertained by questionnaire.
Tobacco smoke exposure resulted in the development of emphysema.
Tobacco smoking during pregnancy remains common , especially in indigenous communities , and likely contributes to respiratory illness in exposed offspring.
Tobacco smoking is responsible for substantial morbidity and mortality worldwide , in particular through cardiovascular , pulmonary , and malignant pathology.
To balance the essential with the potentially toxic function requires an efficient iron homoeostasis.
To be able to assess patients ' biological age is an important objective to improve their healthspan.
To be more effective , geriatric medicine must evolve to intervene at an earlier stage of the disability process.
To best treat this growing segment of the population , medical care should be based on constant vital sign monitoring.
To best understand the relationship between CR and FA , we recruited and tested independent community-dwelling older adults ( OAs ) .
To be sure , sexuality in old age is a burgeoning field of scientific inquiry.
To better allocate resources , a more accurate prediction on medical service demand is very urgently needed.
To better describe the effects , we propose an elliptical elastic and mathematical model to evaluate myocardial stiffness.
To better understand age differences in brain function and behavior , the current study applied network science to model functional interactions between brain regions.
To better understand and operate on this challenging group of patients , the authors evaluated the surgical experience of their department.
To better understand and treat facial aging , the surgeon should review all available data.
To better understand incidence trends over time requires separation of age and cohort effects , and few prior studies have used this approach.
To better understand origins and consequences of technology acquirement by independent-living seniors , an explorative longitudinal qualitative field study was set up.
To better understand some aspects of bone matrix glycation , we used an in vitro glycation approach.
To better understand the aging process , we must first aim to integrate quantitative biological understanding on the systems and cellular levels.
To better understand the causality in diabetes-cognition relationship , this study investigates the association of older-age diabetes with concurrent and childhood cognitive functioning.
To better understand the factors driving this rise , we apply a two-process vitality model to data from the Human Mortality Database.
To better understand the mechanisms involved in muscle aging , we performed a proteomic analysis of Vastus lateralis muscle in mature and older women.
To better understand the mechanism , we examined neuropathologic changes seen with AF.
To better understand the specificity of DAergic neurodegeneration , we studied Mn toxicity in vivo in Caenorhabditis elegans.
To better understand this effect , we investigated delay-execute prospective memory performance in younger and older adults.
To better understand this , we conducted a concurrent systematic review and meta-analysis of cognitively healthy older adults.
To calculate cancer prevalence , MI ratios were used to model survival.
To calculate the FRAX® the day before the actual OF , the actual fracture was not considered as a previous fracture.
To calculate the test-retest correlation coefficient we re-interviewed @number@ participants from the community.
To calculate YLDs , prevalence estimates were multiplied by disability weights.
To capture the effects of exposure to persistent external disturbances , the notions of allostatic adaptation and allostatic load are introduced.
To carry out realistic in vitro mechanical testing on anatomical tissue , a choice has to be made regarding the buffering environment.
To characterize geometrical shape , an inscribed sphere and circumscribed ellipsoid were fitted on the measurements.
To characterize the AD miRNA signature , we examined genome-wide miRNA and mRNA expression patterns in the temporal cortex of AD and control samples.
To characterize the MR selenoproteome , we sequenced its liver transcriptome.
To characterize the neuroanatomical changes in healthy older adults is important to differentiate pathological from normal brain structural aging.
To check validity of the study outcome , the authors repeated twice with @number@ year interval.
To circumvent this drawback , the dispersions can be gelled or incorporated in semisolid systems , increasing the final formulation consistency.
To claim oneself as an individual was an ongoing identity work along the life course.
To clarify the role of microglia and aging in the pathogenesis of AD , future longitudinal studies involving a large cohort are required.
To clarify the role of microglia and aging in the pathogenesis of PD , future longitudinal studies involving a large cohort are required.
To clarify the role of uPAR on adipogenesis , we examined the effect of uPAR overexpression and uPAR deficiency on the adipocyte differentiation.
To clarify these outstanding questions regarding the individual treatment of patients , independent , science-initiated clinical studies after the market authorization are required.
To clarify this point , we conducted a community-based study , using urinary β ( @number@ ) -microglobulin as a marker of tubular damage.
To clarify this , we investigated @number@ participants of the STYJOBS / EDECTA cohort ( NCT00482924 ) , with ages between @number@ and @number@ years.
To close this gap , parameters of verbal learning were regressed on growth parameters of subjective organization.
To collectively assess whole-brain structural changes , the MRI-based Brain Atrophy and Lesion Index ( BALI ) has been developed.
To compare injection patterns and doses of BoNTA in Westerners within China.
To compare pregnancy rate of the time-lapse selected embryos with embryos after ordinary / standard cultivation.
To compare the molecular and phenotypic changes caused by glucose restriction and fetal bovine serum restriction there is need for an efficient model system.
To compare the prevalence of osteoporosis by adopting male or female BMD reference values the Fisher's exact test was applied.
To compare the two techniques further , finite element analysis ( FEA ) and fractographic assessment using SEM and EDX analysis were conducted.
To compensate for the decline in the adaptive immune function there is a paradoxical up-regulation of innate immune system resulting in a proinflammatory state.
To completely understand the pathophysiology of these lifethreatening diseases , it is critical to elucidate the molecular mechanisms underlying vascular calcification.
To comprehend the neural basis of gait variability with aging and CI , longitudinal studies of multiple brain areas are needed.
To conclude , bilingualism delays the age at onset in the behavioral but not in the aphasic variants of FTD.
To conclude , high cynical distrust associates with increased risk of CVD mortality in CVD-free men.
To conclude , IGF2DMR and H19 DNA methylation is associated with fetal and infant growth.
To conclude , inherent ethnic differences in β-cell function exist independently of adiposity and S ( I ) .
To conclude , it appears that species do not age , even though they are composed of individuals whose somatic and germline cells have aged.
To conclude , the assessed panel of biomarkers proved highly dynamic after liver as well as kidney transplantation in the early post-transplant period.
To conclude , the new service option and the usual care option showed similar improvement in rehabilitation outcomes at @number@ months after baseline.
To conclude , we discuss the future applications of computational systems modelling to aging research.
To confirm the results of the expression profiles , in vitro analysis was performed.
To confirm these observations made on humans , we studied mice overexpressing muscle-specific IGF-1 , which are protected from sarcopenia.
To confirm this age limit for use of this test in diagnostics of pneumococcal diseases , further study in school-age children is justified.
To connect the aging process at different structural , temporal and spatial scales , extensive systems biological approaches need to be deployed.
To consider several key research questions and some of the challenges and impact of neglecting knowledge transfer.
To construct more robust features , voxels can be aggregated into clusters that are maximally coherent across subjects.
To construct the Gerontome database , we integrated aging-related genes and their annotation data.
To contain Long-Term Care ( LTC ) Insurance costs , the Japanese government is attempting to increase the proportion of individuals receiving home care services.
To control for reverse causality and to identify potential long-term effects , we additionally performed analyses with delayed entry.
To control the quality of this food supplement , five active components were monitored.
To control the sensory-motor system , internal models mimic the transformations between motor commands and sensory signals.
To cope with an aging society , development of disease-modifying drugs for Alzheimer's disease ( AD ) is essential.
To cope with immune responses , tumour cells implement elaborate strategies such as adaptive resistance and induction of T-cell exhaustion.
Tocopherols , with a phytyl side chain in its chroman ring , belong to vitamin E family and have several effects on organisms.
To counteract DNA damage , cells employ genome maintenance pathways that are directed inward , relentlessly to scan and repair the genome.
To counteract these processes , antioxidants such as coenzyme Q10 ( CoQ10 ) are contained in many cosmetics.
To counter this , an exogenous supply of anti-oxidants , is required since the endogenous anti-oxidant system cannot alone suffice the need.
To create a reference database , a logarithmic transformation was applied to the data to obtain the 5th-95th percentile values for T2.
To create the various chromatin structures that are necessary for DNA function in higher eukaryotes , histones undergo posttranslational modifications.
To critically test the role of oxidative stress on aging and investigate changes in redox-sensitive signaling pathways , further study is required.
To curb the accumulation of damaged mitochondria , the cell has elaborated a number of mitochondrial quality control processes.
To dampen proteotoxic stresses and maintain protein homeostasis , organisms possess a stress-responsive molecular machinery that detects and neutralizes protein damage.
To date , 898 / 971 ( @percent@ ) have been successfully contacted of whom @number@ ( @percent@ ) have agreed to participate.
To date , absorption spectroscopy has been the primary method to identify and quantitate A2E.
To date , AD therapy is primarily targeted toward palliative treatment of symptoms rather than prevention of disease progression.
To date , all studies using the Aprosodia Battery have yielded statistically robust results.
To date a number of different strategies have been used to identify potentially inappropriate prescribing in older people.
To date , attention to the environmental production of disability among older adults with age-related vision loss ( ARVL ) has been limited.
To date , autologous fat graft has been the treatment of choice for this group of patients.
To date , considerable knowledge regarding the interactions among genes that coordinate retinal development has been gained from extensive research in model animals.
To date , Drosophila melanogaster has been successfully used to investigate pathogenesis following the loss of several other PD-associated genes.
To date , DRPs among BPH patients have not been well studied.
To date E7 oncoproteins have not been investigated in cervical adenocarcinoma.
To date , few studies have summarized knowledge on mortality differentials by country of birth.
To date , few studies have tried to establish what changes the ENPs undergo when they are incorporated into , and released from , products.
To date , four genes have been identified as responsible for TTD : XPD , XPB , p8 / TTDA , and TTDN1.
To date , however , few functions of circRNAs have been identified.
To date , however , no longitudinal studies have evaluated body composition using TBK in aging healthy adults.
To date , however , only a small body of qualitative research has examined older men's experiences and understandings of sex in later life.
To date , however , the molecular mechanisms and functions of these UBLs in the DDR remain largely unknown.
To date , however , this association has not yet been adequately studied.
To date , it is not completely clear what pathways are responsible for loss of fibers in age-related muscle atrophy.
To date , it is unknown which patient group may benefit most from intensive monitoring strategies.
To date , it remains unknown whether and how this APOE promoter polymorphism affects the human brain in aging.
To date , little information about the effects of drug cessation in these four situations is available.
To date little is known about the interactions of SMN with other splicing factor genes and how SMN affects splicing in vivo.
To date , little is known about the mechanisms underlying these effects.
To date , little is known for how smoking can predispose our brains to dementia or cognitive impairment.
To date , longevity studies of elite athletes have been relatively sparse and the results are somewhat conflicting.
To date , many dysphagia diets have been developed and are available commercially to help bring back the pleasure of mealtimes to dysphagia patients.
To date , many questions have been raised : How can brain microangiopathy progression be monitored ?
To date , mechanisms contributing to the age-related alterations in shear rate in humans have only been examined in the conduit vessels of the arm.
To date , mechanisms of action of drugs used for neuraxial anesthesia / analgesia to prevent venous thrombosis are uncertain.
To date , mixed findings have emerged from studies of associative priming in aging.
To date more than @number@ compounds are recognized to belong to the class of flavonoids.
To date , more than @number@ novel genetic loci have been identified in GWAS for age at menarche and @number@ for age at natural menopause.
To date , most of the studies that have investigated the effect of resveratrol administration on patient outcomes have been limited by their sample sizes.
To date , most prognostic studies have tended to be clinical rather than population-based , which necessarily affects the interpretation.
To date , most symptom measures have focused on a particular disease population.
To date , most trunk muscle research has been conducted among younger adults.
To date , MTORC1's and PLK1's functions are mostly studied separately , and reports on their mutual crosstalk are scarce.
To date mTOR inhibitors are clinically approved to prevent organ rejection , to inhibit restenosis after angioplasty , and to treat several advanced cancers.
To date , much evidence has been obtained that contradicts the theories of aging as being due to accumulation of various damages.
To date , muscle fibers can only be characterized by actually obtaining a tissue sample using the invasive muscle biopsy procedure.
To date , no clinical data have been carried out on cognitive dysfunctions employing the quoted patents in men.
To date , no data are available on the accuracy of health care professionals in estimating the remaining life expectancy of older subjects.
To date , no dietary factor has been linked to a higher glutathione concentration.
To date , no large scale , systematic description of the blood serum proteome has been performed in inflammatory bowel disease ( IBD ) patients.
To date , no long-term clinical trials have studied multivitamin use and cognitive decline in older persons.
To date , no measurement instrument has been tested to evaluate resilience in Chinese older people.
To date , no new drug has qualified to be added to the current therapeutic arsenal comprising cholinesterase inhibitors and the NMDA receptor antagonist memantine.
To date , no prospective data are available.
To date no reliable information is available concerning ASC from pediatric patients and a better knowledge is required for clinical applications.
To date , no safety and efficacy study exists on cosmeceutical use in pediatric patients.
To date , no studies have elucidated the mechanism of glial cell activation and cytokine and chemokine up-regulation and release.
To date , no study has examined endocrine and psychosocial factors in parallel with regard to their modifying effect on the age-related increase in ED.
To date , no study has examined the association between smoking and cognitive decline in men living with human immunodeficiency virus ( HIV ) .
To date , no study has explored the effect of caffeine on brain activation patterns during highly demanding cognitive tasks in the elderly.
To date , no study has investigated the association between rare mutations of TREM2 and LOAD risk in non-European population.
To date , no study has presented muscle architecture for the upper and lower limbs of a single cadaver.
To date , no systematic study has addressed how variation in intensity affects recognition of the different type of EFEs in such subjects.
To date , no therapies have been developed that can specifically up-regulate this system.
To @date@ @number@ participants have been recruited.
To date , @number@ patients with MDPL have been reported in the literature and among them @number@ patients have been characterized at the molecular level.
To date , only few studies have investigated these functions across adulthood.
To date , only the last has been proved effective in a randomized study.
To date , pharmacological interventions have shown limited efficacy in counteracting the effects of sarcopenia.
To date , physical exercise is the only intervention consistently demonstrated to attenuate age-related declines in physical function.
To date , research on human resilience responses to and factors influencing these responses has been limited.
To date , research on this coupling remains inconclusive and has not focused specifically on fallers.
To date , resistance training has been shown to be effective in attenuating age-related muscle loss and strength.
To date , scientists have revealed several risk factors for pancreatic cancer , including smoking , family history , and aging.
To date , several genes have been identified as the cause of AD , including PSEN1 , PSEN2 , and APP.
To date , several resting-state fMRI studies reported altered functional connectivity in 22q11.2DS , however BOLD signal variance has not yet been analyzed.
To date , several studies have reported changes in Aβ burden over time.
To date , small longitudinal and cross-sectional studies of young cancer patients demonstrate that gonadotoxic chemotherapy impact ORT.
To date , studies of the 9p21.3 variants on CAD risk mainly focus on the non-coding region of ANRIL.
To date , symptomatic medications prevail as the mainstay of treatment options for Alzheimer's disease ( AD ) .
To date , the care and social integration of individuals with dementia is complicated by limited collaborations between biomedicine and other disciplines.
To date , the consistency of the protective effect of LRRK2 p.R1398H across MAPT and SNCA variant genotypes has not been assessed.
To date , the demographic and acute medical care use patterns of patients in these practices have not been described.
To date , the disease has no effective therapies.
To date , the dual roles of autophagy in ischemia and preconditioning have not been fully clarified.
To date , the expression and biologic functions of TREM2 under AD context remain largely unknown.
To date , the identities of the causal genes underlying physical activity regulation are unclear , with few strong candidate genes.
To date , the influence of tPA in the ischemic brain has only been investigated on neuronal , microglial , and endothelial fate.
To date , the intracellular signaling mechanisms underlying the expression of target proteins regulated by these factors are elusive.
To date , the lens reducing system ( s ) required for MsrA activity has not been defined.
To date , the molecular mechanisms underlying the onset of neuronal physiological changes in the central nervous system remain unclear.
To date , the molecular properties of AGE have been sparsely studied in vitro or in vivo.
To date , the monoclonal antibody eculizumab is the only approved agent.
To date the most effective tool to study genome wide DNA methylation changes is Infinium HumanMethylation450 BeadChip ( Infinium 450k ) .
To date , the pathophysiology and mechanism of action of APE have not been elucidated.
To date the perspectives of this multidisciplinary team have not been adequately explored.
To date , the players mediating this crosstalk have been elusive.
To date , the process of MSC senescence remains unknown as in-depth understanding of the mechanisms involved in cellular senescence is lacking.
To date , there are no approved therapeutics for GA treatment ; however , several are in clinical trials.
To date , there are no study has been found where the kinesthesia and joint position senses have been evaluated together in SIS.
To date , there are no validated hormone cutpoints that predict the length of MT or FMP.
To date , there are numerous hESC lines that have been developed and characterized.
To date , there has been no attempt to systematically assess the breadth of the problem in Canada.
To date , there has not been a clear delineation of the physical and cognitive demands of activities of daily living.
To date , there have been few major applications of this knowledge to establish postinjury interventions in humans.
To date , there have been few studies , with inconsistent findings on the association between pain and neuropsychiatric symptoms.
To date , there is evidence to indicate that there are morphological age differences in the cerebellum that are linked to motor and cognitive behavior.
To date there is no effective therapy for Alzheimer disease ( AD ) .
To date , there is no known study that provides a comprehensive examination or portrait of older persons in prison.
To date there is no normative model of ovarian volume throughout life.
To date , there is no pharmacological treatment available to reverse or hinder the progression of CAVD.
To date , the role of genetic variants in pre-miRNAs on coronary artery disease ( CAD ) risk remains poorly understood.
To date , these research studies have primarily focused on individual determinants , namely : health conditions and lifestyle habits.
To date , the tumor genome has been sequenced in nearly @number@ cases of acute myeloid leukemia ( AML ) .
To date the wide clinical variability of FTLD-GRN remains unexplained.
To date , this gene had not attracted attention in the literature on smoking.
To date two main aging vascular lesions have been reported in elderly human retinas : acellular capillaries and microaneurysms.
Today , a de novo or inherited genetic abnormality can be identified as pathogenic in one-third of cases.
Today , Alzheimer's disease ( AD ) is one of the most important age-related neurodegenerative diseases , but its etiology remains still unknown.
Today , a variety of medical therapies and minimally invasive BPH treatment modalities are available.
Today , guideline-recommended heart failure therapy is still too often withheld from elderly patients out of fear of potential side effects.
Today , however , a different equation is needed on which to base such projections.
Today it is clearly evident that genetic background constitutes an integral part of aging and longevity.
Today more men work in the long-term care sector , but men are still in the minority.
Today , only little is known about the influence of multimorbidity on cognition in a normal healthy aging population.
Today , over @number@ million people suffer from Alzheimer's disease ( AD ) worldwide.
Today , owing to the effectiveness of ART , the HIV-infected population is aging and HIV infection has become a chronic illness.
Today's interconnected world has produced a distinct need for physician specialists in public health and preventive medicine.
Today's population is aging and patients are diagnosed with more co-morbid conditions than in the past.
Today , such ageing is recognized as a threat for developed societies.
Today , their status is being questioned.
Today , the scientific literature is scarce for chronic pain in combination with multiple coexisting medical conditions and medication regimens.
Today , we know that reconstitution of the epidermal barrier after irritation is delayed once it has been impaired.
Today we know that this is not enough to ensure health in the rest of the life.
Today we report long term ( two to three year ) clinical efficacy.
Toddler NutriSTEP was developed in @number@ phases.
To decrease this gap between theory and experimental observations , we incorporate recent data on cellular and molecular factors underlying gliomagenesis.
To define a normal range , @number@ active subjects were recruited with an age range of @number@ to @number@
To define a population at high fracture risk , we selected patients in the orthopedic emergency cohort from Shanghai Sixth People's Hospital , China.
To define the early stages of the aging process may allow early detection of pathologic changes and therapeutic interventions.
To define the impact of increased iP expression we crossed APPPS1 mice with mice deficient in the iP subunit LMP7 resulting in impaired iP function.
To define the retinal phenotype of subjects with familial dysautonomia ( FD ) .
To define the significance of the UPR to AD , we targeted IRE1 expression in a transgenic mouse model of AD.
To deliver siRNAs into cells , we fused a peptide transduction delivery domain to a dsRNA-binding domain ( PTD-DRBD ) .
To demonstrate its capability to work on non-human primates , the proposed method is further evaluated using a rhesus macaque dataset with @number@ subjects.
To demonstrate the performance of our system , five young healthy subjects were recruited.
To demonstrate the utility of AlzBase , we examined the genes from the genetic studies of AD.
To demonstrate translational efficacy , mechanism , feasibility , and safety , we conducted a group of translational experiments.
To describe characteristics of coherence in nonagenarians.
To describe normal ageing using vaMTA.
To descriptively analyze the ECtHR cases that deal with older persons and elder rights issues.
To detect a difference in the mean quality of life at @number@ months , we anticipate studying a minimum of @number@ patients from @number@ GPs.
To determine a role for ghrelin in modifying taste perception , we performed taste behavioral tests using GHSR null mice.
To determine changes in cognition across @number@ years , we utilized mixed effects models.
To determine correlation between different study groups , parametric and nonparametric methods were used.Significance was determined with @percent@ of variability.
To determine differences between peripheral blood mononuclear cells and the plasma metabolites in patients with impaired fasting glucose or type @number@ diabetes and healthy controls.
To determine if the FUS mutations in sALS were de novo , we performed genetic analysis on @number@ sALS patients with living parents.
To determine if this could contribute to muscle loss , we studied fed-state metabolic responses in healthy , non-sarcopenic elderly women.
To determine minimal detectable changes at the @percent@ confidence level ( MDC95 ) , each participant was assessed using the PMS on @number@ occasions.
To determine mitochondria-mediated apoptotic activity , we examined mitochondrial membrane potential , cytochrome c release , and caspase-3 activation.
To determine NL , bonded sticks from each experimental condition were immersed in silver nitrate and analyzed by SEM.
To determine performance differences associated with normal aging , we test older and younger adults in a dynamic control task.
To determine the age-related physical capability healthy men and women at the age over @number@ years were studied.
To determine the biological role of these DGs , null animal models have been generated.
To determine the clinically important difference , participants were also tested on @number@ separate occasions @number@ months apart.
To determine the functional age of an individual , a quantitative system for the assessment of aging status was developed in the present study.
To determine the line's status , the analysis of the surface markers by flow cytometry was carried out.
To determine the mechanism of action , anti-oxidative experiments and ROS assay were performed.
To determine the molecular etiology of this disease , we performed whole-exome sequencing and targeted Sanger sequencing.
To determine the organic chicken consumer profile , the organic chicken consumption frequencies of different demographic groups were compared.
To determine the physiological importance of the Wnt pathway , we developed a mouse model with germ cell-specific constitutive activation of βcatenin.
To determine the position of the longevity gene , additional genetic markers data are needed.
To determine the reason , we repeatedly performed videofluoroscopic examinations ( VF ) in @number@ patients with SCA6.
To determine the relationship between AGE accumulation in tissue and muscle strength and power among Japanese adult men.
To determine thresholds , spline curves were used.
To determine whether CR mitigates age-related memory decline , we examined the effects of gender and APOE genotype on longitudinal memory performances.
To determine whether dietary behavior , physical activity , and screen time varied among students in different stages of their education.
To determine whether laparoscopic surgery is safe and feasible in patients with severe senile kyphosis.
To determine whether mitochondrial output is affected by the selective reduction in complex I + III activity , we examined tissue levels of high-energy phosphates.
To determine whether self-reported functional losses are similar to those measured objectively and which best represent overall physical capacity.
To determine which occupational hazards cause this increased risk and morbidity , it is imperative to study law enforcement officers before they retire.
To develop age-adjusted therapeutic interventions , a clear understanding of the complexity of age-related post-ischemic mechanisms is essential.
To develop an applicable prediction for obstructive sleep apnea ( OSA ) is still a challenge in clinical practice.
To develop more efficient treatment strategies in patients with schizophrenia , a better understanding of the pathogenesis of these cognitive deficits is needed.
To develop new therapies , we need to aim at alleviating widespread cellular defects in addition to those focusing on DA neuronal survival.
To develop successful therapies that prevent or treat neurodegenerative diseases requires an understanding of the upstream events.
To develop such therapeutics , we initially screened a small chemical library and selected compound @number@ whose IC ( @number@ ) is about @number@ μM.
To develop these biomarkers , the methylation of multiple CpG sites is typically linearly combined to predict chronological age.
To diagnose ADHD , the DIVA @number@ a diagnostic interview was administered among a subsample ( N = 230 , age 60-94 ) .
To diagnose mucormycosis , direct microscopy preferably using optical brighteners , histopathology and culture are strongly recommended.
To differentiate MCI from low overall ability , criteria included adjustment for GCA measured at approximately age @number@ years.
To discern policy effects , the model was initialized in a steady state.
To disclose differences between different age groups , a Kruskal-Wallis test was applied.
To discover rare PD susceptibility variants , we performed WES in @number@ unrelated cases and @number@ control participants.
To discover whether changes in foot morphology and pain tolerance may favor the use of inadequate footwear in old age.
To discuss the characteristics of the disease in the elderly , medical records of @number@ consecutive cases of pyogenic spondylitis were reviewed.
To disentangle the source of this deficit we compared the cumulative semantic interference effect ( Howard et al. , @number@
To distinguish PD from enduring personality changes caused by various physical and psychiatric conditions is also an important and difficult task.
To distinguish these opposite hypotheses , two criteria need to be observed.
To document age-severity relationships , retroillumination photographs were acquired from members of both families.
To do so , health care systems must be prepared to care for this growing and aging population.
To do so , large-scale data need to be collected through cooperative group mechanisms.
To do so , muscle tissue was individually digested with a purified collagenase.
To do so , we employed a novel parainformative experimental task involving categorical stimuli with four objects defined over three dimensions.
To do this , interested researchers should contact one of the principal investigators of the GAZEL Cohort Study.
To do this , the article presents data collected in expert interviews and document analysis.
To do this , we studied @number@ animals ( age , 18-29 y ; weight , @number@.24- @time@ ) .
Toe clearances of both the lead and trail limb ( LTC and TTC ) were calculated.
To effectively promote community mobility , the social lives and needs of individuals must be addressed.
To efficiently isolate and amplify hSGSCs in large amounts , we developed a culture system ( lasting 4-5 weeks ) without any selection.
Toe flexor and handgrip strength , anthropometry , and resting blood pressure were measured.
To eliminate the potential confounding effects of aging and handedness , we restricted the study to right-handed subjects aged 21-29 years.
To eliminate this problem , the Montreal Cognitive Assessment ( MoCA ) was developed , especially for screening MCI.
To elucidate age and sex differences in FAP , we investigated biochemical characteristics of amyloid deposits in different tissue sites of FAP by proteomic analysis.
To elucidate the relationship between aging and remodeling of the cardiovascular system , firstly , it is necessary to clarify the phenomena of cellular aging.
To elucidate the underlying mechanism of ROCK in regulating ROS levels , we performed a yeast two-hybrid screen and discovered that ROCK1 interacts with Rac1b.
To elucidate this interplay further , we present a comparative proteome study of inflammatory and angiogenic activated endothelial cells.
To elucidate this observation analysis of larger samples is needed.
To emphasize disease modification and prevention , we describe a multi-disciplinary systems-based approach encompassing biology , mechanics , and structure to define pre-osteoarthritic disease processes.
To enable such early treatment , preclinical AD biomarkers are required.
Toenail samples were taken and analyzed using ICP-MS to determine trace element levels.
To encourage non-users to adopt technology , there is a need to remove barriers at personal , technological , and environmental levels.
To engage FPs in the process , however , the barriers should be addressed.
To enhance self-care , interventions should be tailored to increase patient health literacy and perceived capacity for communication with health care providers.
To enhance the effects of PDT , it is essential to inhibit the Wnt / β-catenin signaling pathway involved in EMT progression.
To enhance the sensitivity forward searches were conducted in Scopus and Web of Science.
To enhance the sustain ability of labor in an aging society , more studies on ERdHP are needed.
To ensure consistent generation of high quality data , we incorporated a system suitability protocol ( SSP ) into our experimental design.
To ensure that encoding of missing data is sufficient to understand the reason why data are missing , it should ideally be context-free.
To ensure the functional and genomic integrity of blood tissue , a network of regulatory pathways tightly controls the proliferative status of HSCs.
To ensure this population is treated fairly in terms of claims on resources , we first need to identify areas for methodological improvement.
Toe position-time coordinates were acquired using a @number@ dimensional motion capture system.
To establish adequate intake of water , the comprehensive effect of gender , age , BMI and region when should be considered.
To establish a more effective and safer treatment protocol , the issue of malnutrition in elderly patients needs to be addressed and improved.
To establish a performance baseline , all participants were first pretested on a typical ID = @number@ Fitts task.
To establish the diagnosis and follow up new treatments , useful urodynamic parameters and threshold values have to be determined.
To establish these parameters , further studies on the another examination in representative group of children and teenagers are necessary.
To estimate hazard ratio ( HR ) of TOX-MOD during the first year of combined antiretroviral therapy Cox's proportional hazards regression was applied.
To estimate life expectancy for non-extinct cohorts , we apply the Lee-Carter model to extrapolate mortality rates until the year @number@
To estimate the association between age at menarche and age at natural menopause , a Cox semi-parametric model was fitted.
To estimate the heritability of CRP as well as its genetic and environmental correlations across different time points , a trivariate model was used.
Toe strength was assessed using a pressure platform.
To evaluate and compare the exercise responsiveness of various reported inflammatory markers , pre- to post-test effect sizes were calculated.
To evaluate factors independently associated with fracture risk.
To evaluate for potential non-response bias , drop out weights were used in sensitivity analysis.
To evaluate gender differences in heart failure patients.
To evaluate LIF-mediated integrin expression , knockdown of LIF by shRNA was performed in Ishikawa cells.
To evaluate possible transfer effects , executive functions were assessed with two tests before and after training.
To evaluate safety of repeat exposure , treatment was administered at baseline and week @number@
To evaluate S. aureus and MRSA carriage among the elderly , we conducted a large cross-sectional study between @date@ and @date@ .
To evaluate secondary efficacy endpoints , response rates were measured at weeks @number@ @number@ and @number@ at maximum frown and rest.
To evaluate the accuracy of observer age estimation , the patients ' preoperative estimated mean age was compared with the patients ' actual mean age.
To evaluate the clinical parameters , patients completed the IPSS and IIEF-15 questionnaires preoperatively and @number@ year postoperatively.
To evaluate the current status of medical treatment for LOH in Japan , the first nationwide survey were performed.
To evaluate the early diagnosis and survival rates , the mortality-to-incidence rate ratio ( MR / IR ) was calculated from the IARC data.
To evaluate the effect of RACK1 pseudosubstrate on cytokine production and CD86 expression the whole blood assay was used.
To evaluate the efficacy and safety of Princess VOLUME in the treatment of nasolabial folds , an open-label uncontrolled , multicenter study was conducted.
To evaluate the efficacy of the bariatric surgery BAROS method was applied.
To evaluate the empirical support for these claims , we reviewed the evidence base on supported decision-making.
To evaluate the impact of patient age for the embryonic growth.
To evaluate the performance of the system , we measured the effect of assistance quantitatively.
To evaluate the prognostic properties of the two different approaches , data on mortality of the screened residents were collected during a six-month follow-up period.
To evaluate the prognostic values , events were defined as the combined endpoints of death or HF-related re-hospitalization.
To evaluate the relation between microvessel supply and age , a regression model with curvilinear estimation was used.
To evaluate these biochemical parameters , current technology requires several hundred milligrams of isolated mitochondria for functional assays.
To evaluate the sexual symptoms of aging male's was used the sexual dimension of the AMS scale - The Aging Male's Symptoms Scale.
To evaluate this hypothesis , we reviewed findings from the existing literature and findings from our own lab.
To evaluate whether autophagy regulates mitochondrial function , chondrocytes were pretreated with rapamycin and torin @number@ before oligomycin.
To evaluate whether disagreements were related to dementia severity , we repeated comparisons across levels defined by the clinical dementia rating.
To evoke ALR sequences , we generated syllabic paradigms with a different level of difficulty to evoke ALR sequences.
To examine biological themes , we selected @number@ DMRs with false discovery rate of < 0.1.
To examine identification performance , the authors used a standard response-type analysis , receiver operating characteristic analysis , and signal-detection process modeling.
To examine incident frailty , included were a subset of @number@ participants without baseline frailty or development of exclusion criteria during follow-up.
To examine potential associations of the history of lifetime smoking and smoking cessation with cognitive function in the elderly.
To examine specifically whether cellular ageing , as measured by leukocyte telomere length ( LTL ) , is correlated with the presence of endocrine disturbance.
To examine the impact of mild AD on the olfactory function , we compared the scores between the AD group and the age-matched control group.
To examine the influence of patient and hospital characteristics , @number@ admissions in @number@ were used.
To examine the role of inflammasome-driven IL-18 in murine CAPS , we bred Nlrp3 mutations onto an Il18r-null background.
To examine the underlying mechanism of action , we utilized an in vitro human brain microvascular endothelial cell ( HBMEC ) culture system.
To examine this , @number@ ( @number@ young ( ≤35 years ) and @number@ aged ( ≥60 years ) ) healthy males were recruited.
To examine this phenomenon , we compared older and younger adults in categorical perception of faces.
To examine this , we compared the ability of @number@ and @number@ year olds and adults to detect audiovisual temporal asynchrony.
To examine various aspects , we performed individual region of interest ( ROI ) analysis , as well as conventional random effect group analysis.
To exclude paracrine / autocrine stimulation as a potential mechanism , we generated Ba / F3-EpoR-JAK2WT or EpoR-JAK2V617F cells lacking CXCL10 receptor.
To exclude the interference of emergency treatments , FP / CIT BP was also evaluated in @number@ patients currently treated with apomorphine.
To execute the rotifer-based experiments , we developed an oil-covered water-drop methodology adapted from human in vitro fertilization techniques.
To experimentally determine how the competent brain-pull functions to demand for cerebral energy , healthy young men undergoing psychosocial stress were studied.
To explain the pleiotropic effects of resveratrol , the molecular targets of this compound have to be identified on the cellular level.
To explore effective preventive strategies and interventions , we studied adult age-related differences in multijoint coordination to control the COM during balance recovery.
To explore the correlation between the CR1 gene and LOAD , a 2-step design study was conducted in our Northern Han Chinese population.
To explore the effect of the potential risk factors on the prevalence of dysphagia , a model was built by multivariate logistic regression analysis.
To explore the experience of living alone among older men.
To explore the function of LRRK2 variants in vivo , we performed mass spectrometry and quantified @number@ proteins in the fly brain.
To explore the impact of age on iPSC quality , we produced iPSCs from blood cells of @number@ donors aged 21-100.
To explore the intersection of culture with the expression of dementia may optimize the management of these complex and chronic conditions.
To explore this hypothesis , we developed a highly specific ELISA to measure alpha-synuclein.
To explore this issue , studies with repeat measurements of height are required , but , to date , such data have been lacking.
To extract the high-frequency components of the wall motion , wall vibration , the empirical mode decomposition was then used.
To facilitate the development of such guidelines , this paper provides an overview of the literature on sensory features in autism spectrum disorder.
To facilitate the participation of frail elderly patients in clinical trials , investigators should be more aware of possible barriers when setting up research.
To facilitate the search for them , here we provide our detailed protocol for the characterization and generation of tumor-evoked regulatory B cells.
To facilitate these medical advances , funding agencies are increasingly focusing on a translational \ "payoff \ " within grant applications and larger programs.
To facilitate the transition from the MMSE to the MoCA in clinical and research settings , authors have developed MMSE-MoCA conversion tables.
To fill this demand , the American Geriatrics Society Geriatrics for Specialist Initiative established the Geriatrics Education for Specialty Residents Program ( GSR ) .
To fill this gap , the present study involves in-depth interviews of medical travel facilitators with extensive exposure to and communication with medical travelers.
To fill this gap , this study draws on power relations to examine communication dynamics when oldest-old and their adult children decide to institutionalize.
To fill this imbalance and improve graft outcomes , the transplant of @number@ older kidneys in the same recipient has been proposed.
To find gene expression modules active in breast cancer subpopulations , we assembled @number@ breast cancer-related gene expression datasets containing ∼5 , 700 samples altogether.
To find the most suitable Cutometer parameter that reflects age-related changes in the elasticity of cheek skin using multiple suctions.
To fulfill this objective we recruited for this cohort study adults aged ≥40 years residing in the Agincourt sub-district of Mpumalanga Province.
To fully analyze the influence of parental age on the offspring is of great significance in deciding the optimal age for parenthood.
To fully appreciate the peroxide-mediated cellular effects , we assessed these adaptive effects at the genomic , proteomic and cellular signal processing level.
To fully disentangle what appears to be an endless quest , all the components of the complexity of human longevity genetics are taken into account.
To functionally characterize the associated variants , we used flow cytometry to measure TREM1 expression on monocytes.
To further address this announcement , in @date@ , scientists with varying perspectives came together at Georgetown University to discuss the following questions.
To further assess variability and dependence on electrode separation , age and sex , recordings from an additional @number@ normal volunteers were added.
To further characterize the effect of face-lift surgery , estimated ordinal-rank change was calculated for each domain.
To further define the genetic basis of atrial fibrillation , we performed large-scale , trans-ancestry meta-analyses of common and rare variant association studies.
To further elucidate the role of extrinsic mortality in the evolution of aging , we implemented a stochastic , agent-based , computational model.
To further explore our findings , we compared atrial cell telomere length and LTL in cardiac surgery patients.
To further explore the model , quantitative survey data were collected from the residents three years later.
To further explore the roles of miR-30c in EMT and tubulointerstitial fibrosis , recombinant adeno-associated viral vector was applied to manipulate the expression of miR-30c.
To further interrogate the disuse hypothesis , we adjust for confounding from health and socioeconomic sources.
To further investigate Sgs1's regulation , we analyzed the subcellular localization of a fluorescent fusion of Sgs1 upon DNA damage.
To further validate our findings , we get the results of @number@ samples from a cohort of European ancestry.
To gain insight into human control strategies , we operationalize predictability and robustness to permit quantitative theory-based assessment.
To gain insight into these experiences , focus groups of hematology / oncology fellows were conducted.
To gain mechanistic insights , we developed a novel mouse model based on a mutation in human optineurin associated with hereditary , low-pressure POAG.
To gain more insights , we combined methods of genome-wide and candidate-gene studies.
Together , a network of clinical risk factors , called the biological continuum based etiological network ( BCEN ) , was constructed.
Together , it seems that mild increases of ROS levels do not significantly influence the natural rate of aging.
Together , more than @number@ persons have agreed to annual clinical evaluation and brain donation at death.
Together , NBP protects DA neurons likely by reducing oxidative stress , offering an alternative neuroprotective medication for Parkinson's disease.
Together , our data establish that insulin signaling specifically inhibits regeneration in aging adult neurons and that this mechanism is independent of PTEN and TOR.
Together , our data indicate that MUC1 can inhibit apoptosis via activating JNK1 pathway in response to genotoxic anticancer agents.
Together , our data reveal the existence of an NER-independent mechanism to remove UV-induced DNA damage and prevent cell death.
Together , our data show that endogenous BACE1 activity regulates total and surface levels of voltage-gated sodium channels in mouse brains.
Together , our data suggest that APP K724M gene mutation may contribute to the cause of this Chinese early-onset familial AD.
Together , our data suggest that different tau strains determine seeding potency and cell-type specificity of tau aggregation that underlie the diversity of human tauopathies.
Together , our data suggest that SIRT6 may serve as a potential therapeutic target for HMGB1-mediated inflammation after cerebral ischemia.
Together , our data support a role for cardiomyocyte-derived miR-18 / 19 during cardiac aging , in the fine-tuning of cardiac ECM protein levels.
Together , our findings demonstrate that programmed cell death effectors influence the degree to which C. elegans tolerates environmental stress.
Together , our findings identify a mechanism of post-transcriptional regulation of insulin biosynthesis.
Together , our findings primarily implicate hypoxia , oxidative stress , as well as membrane lipid remodeling in progression to AD.
Together , our findings revealed a novel function of Numb and its likely mechanism in regulation of autophagy events.
Together , our findings supporting a role of membrane lipids and cholesterol in cell-in-cell formation probably via regulating actomyosin contraction.
Together , our results imply that MCL may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders.
Together , our results indicate that miyabenol C is a prominent β-secretase inhibitor and lead compound for AD drug development.
Together , our results suggest that dysfunction of the Parkin-PARIS pathway may play a deleterious role in rRNA transcription and contribute to PD pathogenesis.
Together , our results suggest that gamma-hydroxybutyrate , acting via HDAC inhibition , upregulates neprilysin to reduce Aβ level and related memory deficits.
Together , our study presents many research opportunities in post-genomic biomarkers development.
Together , the analyses highlight what may be missed when stress is used as a simple unidimensional construct and can guide differential intervention efforts.
Together the collaborating partners translated the research data and findings about growing older and ' widowhood ' into a high quality theatre production.
Together the data demonstrate a non-invasive androgen supplementation paradigm that restores youthful circulating androgen levels in old male primates.
Together , the data suggest that many factors need to be considered before resveratrol can be used for human cancer prevention or therapy.
Together , the evidence speaks for substantial plasticity in emotion recognition ( i.e. , within-person variability ) well into old age.
Together , the @number@ ASM modes demonstrated good discrimination of incident hip fracture.
Together , the positive changes due to human and physical capital accumulation will likely outweigh the problems of declining support ratios.
Together , the results underscore how mode effects may contribute to inconsistent findings in the socioemotional aging literature.
Together these data establish a role of fahd-1 to maintain mitochondrial function and consequently physical activity in nematodes.
Together , these data establish that AR promotes ESCC growth and is associated with poor patient prognosis.
Together , these data identify an age-associated shift in the temporal orientation of recollection and quantify the relationship between AM and PM.
Together these data indicate that cellular senescence significantly contributes to the extracellular matrix changes associated with aging in a mTOR 1-dependent mechanism.
Together these data provide evidence that the A192T variant in TREM2 could contribute risk for AD.
Together , these data suggest that age-related cognitive and motor decline may share a common causation.
Together , these data suggest that DNA damage down-regulates ΔNp63α , which may directly contribute to DNA damage-induced apoptosis.
Together , these data suggest that GATA-6 acts as a transcriptional repressor of CAV1 gene expression in PBOO-induced BSM hypertrophy in men and mice.
Together these data support a role for lipid peroxidation in the progression of Alzheimer's disease.
Together these data support the view that PDGFB , a mitogenic growth factor , has a limited ability to induce senescence.
Together , these factors present serious concerns for immigrant seniors ' economic well-being.
Together these findings demonstrate an intrinsic lung pathology in NPC disease that is of early onset and worsens over time.
Together these findings demonstrated that miR-125b is a negative regulator of CCL4 and its reduction is partially responsible for the age-related increase of CCL4.
Together , these findings demonstrate that skin contains a self-sustained circadian clock undergoing age-dependent changes.
Together these findings highlight how changes with age could contribute to pathogenesis in neurodegenerative diseases and disruption of RNA homeostasis.
Together , these findings indicate that oxidative stress is not a major cause of somatic mtDNA mutations.
Together , these findings indicate that part of the age-related decline on rule induction tests may be the result of a decline in episodic memory.
Together , these findings provide evidence that RER1 is a novel and potential important mediator of elevated αSyn levels.
Together , these findings revealed that miR-217 promotes fibroblasts senescence by suppressing DNMT1-mediated methylation of p16 and pRb by targeting the DNMT1 @number@'-UTR.
Together these findings reveal significant differences between the three murine tau isoforms that are likely to reflect different neuronal functions.
Together these findings suggest regional age-related decrements in heat-activated sweat gland function but not cholinergic sensitivity.
Together these findings suggest that activation of PI3 / AKT pathways by IGF-1 is involved in IGF-1 neuroprotection against apoptosis following proteasome inhibition.
Together , these findings suggest that ERC and CA1-SRLM share vulnerability to both age and AD-associated atrophy.
Together , these findings suggest that the inheritance of phenotypic traits through male germ-line epigenome may represent the unique manner of adaptation during evolution.
Together , these findings support a model in which FOXOs mediate a trade-off between cancer and aging.
Together , these illnesses produce a significant economic burden to the healthcare system.
Together these interlinked pathways form the extended cardiovascular continuum.
Together , these multivariable models explained only 11-17% of the variance in predicting subjective sleep quality.
Together , these observations indicate that AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.
Together , these observations uncover the role of MPV17 as a Δψm-modulating channel that apparently contributes to mitochondrial homeostasis under different conditions.
Together these processes shape the relationship between brain structure and function over the lifespan.
Together , these results converge on the conclusion that age-related decline in memory-dependent choice performance can be minimized via functional compensation in vmPFC.
Together , these results have implications for an understanding of some of the changes in social function seen in abnormal adult aging.
Together , these results shed new light in understanding the molecular mechanisms promoting Cofilin1 dysregulation , both during aging and AD.
Together , these results show that tau pathology is related in a region-specific manner to cognitive impairment in Alzheimer's disease.
Together , these results suggest that age-related differences in balance performance are explained in part by alterations in muscular mechanical properties.
Together , these results suggest that aging of motor and executive control mechanisms may contribute to age differences in speech production.
Together these results suggest that amylin analogs have neuroprotective properties and might be of therapeutic benefit in AD.
Together , these results suggest that EGCG induces myogenic differentiation through TAZ , suggesting that TAZ plays an important role in EGCG induced muscle regeneration.
Together , these results suggest that fisetin may provide a new approach to the treatment of AD.
Together these results suggest that high levels of MS4A6A in emerging AD pathology are detrimental.
Together , these results suggest that SNX27 is essential for ependymal cell differentiation and ciliogenesis , and its deletion can promote hydrocephalus pathogenesis.
Together these results suggest that there are significant tradeoffs in the use of dietary supplementation for prevention and treatment of diseases associated with aging.
Together , these results support the notion that chronic stress plays a central role in emotional experience in daily life.
Together , these studies provide new insights into myocardial aging and the relationship to the antifibrotic and antiproliferative peptide CNP.
Together these studies provide the first glimpse into the organization of the proteins and RNA in the telomerase RNP.
Together these studies suggest that complex damage can threaten the genome stability of the stem cell population in older people.
Together , these ultrastructural aberrations and metabolic disturbance all seem to contribute to the molecular pathogenesis and hepatocarcinogenesis present in the Alb-preΔS2 mice.
Together these variables accounted for @percent@ of the variance in QOL ratings.
Together they reveal what drew the participants to exercising regularly despite the challenges associated with their cancer and treatments.
Together , this approach allowed us to assemble a set of novel cancer subtype specific phosphopeptide candidates for subsequent biomarker verification and clinical validation.
Together , this implies that the seeds may be plentiful but they only germinate in the right soil.
Together , this study provides lesion-based evidence for the multidimensional nature of the emotional experiences of envy and Schadenfreude.
Together , this suggests that endogenous autostimulation of the P2X7R may oxidize lipids and impede clearance.
Together this suggests that in the learning of sequential motor tasks the effects of age are more marked for retroactive transfer than for proactive transfer.
Together , those factors shape the ethical necessity of physicians offering and patients accepting the ICD in late life.
Together , we demonstrated that PUMA activation involved in Aβ-induced apoptosis , representing a drug target to antagonize AD progression.
Together , we identified several age-dependent metabolic alterations that might affect cellular signaling , epidermal barrier function , and skin structure and morphology.
Together with a better understanding of age-specific changes in the biology of PCNSL , this will pave the road for elderly tailored therapies.
Together with axons , myelin is a prerequisite for the higher functions of the central nervous system and complex forms of network integration.
Together with conventional microscopic observations , morphometric analysis on the islet , islet endocrine cells , and amyloid deposition was conducted on immunostained sections.
Together with meso-zeaxanthin , a conversion product of lutein in the macula , they form the macular pigment.
Together with oak , sweet chestnut wood ( Castanea sativa ) have been often used for such purpose.
Together with previous findings , these data posit a novel connection between tau and Aβ , suggesting a dynamic mechanism of positive feed forward regulation.
Together with reduced production of Th1 cytokines , observed immune changes may contribute to health risks associated with PTSD.
Together with the inhibitory effect on microglial activation , propolis may be beneficial in preventing neuroinflammation during chronic periodontitis.
Together with two investigations results indicated that cataract is the first cause for the vision disability.
To help address these questions we suggest some experimental approaches that other laboratories might consider.
To help determine optimal program structure in future years , @number@ of the facilities participated in a single half-day collaborative training session.
To help elderly people handle the stimulator by themselves , the user interface is kept very simple.
To help inform injury prevention efforts , we sought to examine commenters ' stated opinions regarding firearm safety counseling HCPs.
To help persons with this disease perform a variety of activities , our research team developed AP@LZ , an electronic organiser specifically designed for them.
To help understand why , this study investigated the neural correlates of audiovisual synchrony judgments in older adults using electroencephalography ( EEG ) .
To identify additional causes of DDD , we performed exome sequencing in five unrelated affected individuals without mutations in KRT5.
To identify a potential biological basis for disease duration , neuroimaging measures of white matter integrity were evaluated ( n = @number@ ) .
To identify distinct antibody profiles among adults 50-to-74 years old using influenza A / H1N1 HI titers up to @number@ days after vaccination.
To identify DRP , official drug information sources were consulted , and the STOPP and START tool was used.
To identify new loci and refine known loci influencing these lipids , we examined @number@ individuals using genome-wide and custom genotyping arrays.
To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry , we performed both single and multiple-trait genome-wide association analyses.
To identify patients at high risk is the first step in prevention as most of the iatrogenic diseases are preventable.
To identify protein requirements , it is necessary to be familiar with basic physiology , practical methods , and dose response of protein delivery.
To identify resilience resources related to reliable interindividual differences in coupling and damping between stress and negative affect , we examined possible protective factors.
To identify Rhox5-regulated genes , we generated 15P-1 Sertoli cell clones expressing physiological levels of Rhox5 from a stably transfected expression vector.
To identify the benefits and challenges of participating in the course from the perspective of student nurses and older adults.
To identify the causal gene , the exomes of two affected and one unaffected individual have been sequenced.
To identify the DMN , seed-based FC of the posterior cingulate was calculated.
To identify the factors associated with mobility , we used the univariate and multivariate logistic regression analysis.
To identify these age-specific changes , we reviewed @number@ patients with upper cervical spine injury.
To identify the underlying cognitive dimensions of the two test batteries , maximum likelihood factor analyses with a promax rotation were conducted.
To identify the upstream regulators of AIMP3 / p18 during senescence , we screened for potential epigenetic regulators and for miRNAs.
To illustrate , for people with low social participation , disability emerged as the strongest correlate of differences in late-life well-being trajectories.
To illustrate how this can work we analyzed data observed on the spread of vancomycin-resistant Enterococcus in an intensive care unit.
To illustrate such a multifactorial approach , we present two patients with chronic dizziness.
To illustrate the interest in EV biology , we discuss EV RNAs in cancer and neurodegeneration , two major age-associated disease processes.
To illustrate the nature of dyadic interviewing , we present summaries of three studies using this method.
To illustrate this , the current review focuses on the stereotype threat that older adults face about their cognitive abilities.
To illustrate , we have put together a special edition dedicated to metal-related neurological disease.
To implement discontinuation programs , complex multidisciplinary interventions should be offered taking existing barriers into account.
To improve accessibility and affordability of hearing treatment for persons with dementia , there is a need for unique service delivery models.
To improve and optimize cell / tissue penetration properties of the lipophilic CoQ10 , ultra-small lipid nanoparticles ( usNLC ) were developed.
To improve care , hospital staff must be more sensitive to older patients ' uncertainties.
To improve clinician-patient communication , interventions must be tailored to the patients ' literacy level.
To improve health care it is paramount to understand and address challenges , including cognitive issues , facing aging physicians.
To improve insight into the mechanisms of postmenopausal osteoporosis , we combined transcript profiling with DNA methylation analyses in bone.
To improve overall health , it may be beneficial for this population to focus on dietary modifications to reduce the risks associated with chronic diseases.
To improve services through better coordination , some communities have formed multiagency hoarding teams ( MAHT ) , which include aging services.
To improve the body's overall resistance against DNA damage , maintaining a healthy and active lifestyle is desirable , especially in the elderly.
To improve this situation , incorporating PSA screening for prostate cancer , as well as constructing a nationwide cancer registration system , will be helpful.
To improve this situation we should keep a high index to TB and make better use of novel diagnostic technologies.
To improve treatment efficacy , it is important to better understand determinates of cell efficacy in the different patient cohorts.
To increase cellular efficacy , we created CYGAK-S-phenyl-oleic acid heterodimers.
To increase inclusion rates , follow-up measurements were taken at a home visit.
To increase the efficacy of the technology , its use was supplemented with individual performance reviews of the automatically collected data.
To induce progressive , physiologically relevant , muscle atrophy , rats were cast immobilized for @number@ @number@ @number@ or @number@ days and muscles harvested.
To inform clinical trials about this heterogeneity , we report how humans ' pace of biological aging relates to personal-history characteristics.
To inform decision-making , tools are available to estimate life expectancy and to educate older women about the benefits and harms of mammography screening.
To investigate age related decline when reaching-to-lift an object we used sophisticated kinematic apparatus to record reaches carried out by healthy older and younger participants.
To investigate changes in spinal reflex excitability , the H-reflex was assessed in the soleus muscle during quiet upright stance.
To investigate everyday memory , more and more studies rely on virtual-reality applications to bridge the gap between in situ approaches and laboratory settings.
To investigate further the effects of piracetam on mitochondrial function , especially mitochondrial fission and fusion events , we decided to assess mitochondrial morphology.
To investigate neurocognitive dysfunctions in asymptomatic older adults with T. gondii positive antibody status a double-blinded neuropsychological study was conducted.
To investigate other potential effects of GNE mutations , we compared sialic acid production in cell lines expressing wild type or mutant forms of GNE.
To investigate RCT in vivo , 3H-cholesterol-labeled and acetyl LDL-loaded RAW264.7 cells were injected into mice.
To investigate risk factors , control patients were randomly selected from these subjects.
To investigate sex-specific differences in the pattern of brain aging , we repeated the above voxelwise calculations after dividing our sample by sex.
To investigate the antitumor activity of PKCF , we used H22 cells , HeLa cells , and Eca-109 cells with Vero cells as control.
To investigate the association between muscle fiber capillarization and indices of insulin sensitivity in healthy older adults.
To investigate the association , we used longitudinal data from the Aichi Gerontological Evaluation Study ( AGES ) project.
To investigate the basis of this deletion , we developed a single-molecule mtDNA combing method.
To investigate the bioconversion of zinc and the physiological effects of their complex ( MZPS ) , the present studies were processed.
To investigate the causal effect of antihypertensive treatment on the onset of treatment for glaucoma , we used a regression discontinuity study design.
To investigate the detailed binding procedures , molecular dynamics simulations were conducted on the hybrid [ @number@ + @number@ ] form-one human telomeric intra-molecular G-quadruplex.
To investigate the influences of different electrolytes disorders for postoperative delirium , the Chi-square test was used.
To investigate the involvement of NADPH oxidase in glutamate-induced H₂O₂ generation , we used small interference RNA ( siRNA ) .
To investigate the mechanisms controlling the development of sitting posture , a single-degree-of-freedom inverted pendulum model was developed.
To investigate the molecular mechanisms underpinning this phenomenon , we focused on IGF-1 / p53 network / signalling pathway , involved in muscle physiology.
To investigate the possibility of technical differences causing lack of replication , further studies are required.
To investigate the prevalence and causes of visual impairment and blindness in a sample of Polish older adults.
To investigate the pulse wave behavior , an experimental study was performed using an artificial polymer tube and viscous liquid.
To investigate the reason for this result , we conducted a three-way ANOVA examining oxy-Hb in both young and elderly participants.
To investigate the role of mTOR , the protein itself and its target proteins p70S6 kinase and 4E-BP1 were quantified.
To investigate these properties , hair samples have been collected among women of different age and then analyzed.
To investigate the time course of executive functions during antidepressant treatment , repeated measures of executive functions are necessary.
To investigate this chapter may help our realization and practice of TCM physiology.
To investigate this factor , previous researchers have tested whether dividing YAs ' attention during encoding equated their RM performance to that of OAs.
To investigate this issue , we performed a transnosological study.
To investigate this phenomenon further , the levels and activity of lipoamide dehydrogenase ( LADH ) were measured in AD and control brains.
To investigate this phenomenon in event memory , in the present study , the authors presented younger and older adults with a robbery.
To investigate this phenomenon , we interrogated @number@ mutation hot spots in blood DNA from @number@ individuals using ultra-deep sequencing.
To investigate this question , we screened a library of compounds with known mammalian pharmacology for compounds that increase C. elegans lifespan.
To investigate this , we examined adult age differences in @number@ healthy participants aged @number@ to @number@
To investigate this , we performed a single-blind sham-controlled randomized crossover pilot study in healthy older individuals ( n = @number@ @percent@ female ) .
To investigate underlying disease mechanisms , induced pluripotent stem cells ( iPSCs ) allow the generation of patient-derived neuronal cells in a dish.
To investigate whether aging affects surgical outcomes by comparing the results of two patient groups undergoing PNL : those over @number@ and those under @number@
To investigate whether DLK1 ( PREF1 ) plays a role in the regulation of adipogenesis in these cells RNAi-mediated knockdown experiments were conducted.
To keep these concepts cost-effective , the suggested solutions are modular.
To learn more about their genetic ancestry , we analyzed @number@ modern and @number@ ancient mitogenomes from Sardinia.
Tolerability of L-AMB was what might be expected.
Tolerability was evaluated by risk differences based on incidences of adverse events and premature discontinuation rates.
Tolerability was excellent , with no increases in irritation parameters noted.
Tolerance and aesthetic quality of the correction obtained indicate considerable safety features and absence of side effects.
Tolerance to shift work is reported to decrease with age.
Tolerance was assessed clinically by a dermatologist and efficacy by an independent blinded photographic assessment.
Tolerance was measured , as well as multiple indicators of health-related physical fitness.
Tolerated grafts were associated with higher hepatocyte p21 expression and greater nuclear area than in the donor livers prior to transplantation.
To limit the effect of reverse causality , analyses were restricted to men without previous vascular disease at baseline.
To limit the nitric oxide production , the mechanism of melatonin formation is used , which has a circadian rhythm.
To live a self-determined life at home is uncontroversally a desire of many ageing people.
TOLLIP expression was downregulated in ALS cells under conditions of inflammation induced by lipopolysaccharide.
Toll-like receptors ( TLR ) are key players of the innate and adaptive immune response in vertebrates.
Toll-like receptors ( TLRs ) are a family of innate immune system receptors that respond to pathogen-derived and tissue damage-related ligands.
Toll like receptors ( TLRs ) are a family of PRRs which recognize endogenous damage associated molecular patterns ( DAMPs ) and subsequently induce inflammation.
To locate the AdipoRs in the retina , immunofluorescence was performed.
Tolterodine is a good option as part of the algorithm in the treatment of OAB and UUI.
To maintain a high glycolytic rate , cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters ( MCT1 / 4 ) .
To maintain LLMS the question arises whether habitual physical activities ( HPA ) can prevent a decline in LLMS.
To maintain optimal tissue and body function , organisms have developed complex mechanisms for tissue homeostasis.
To maintain optimum body function , the organisms have developed complex mechanisms for homeostasis.
To maintain structural homeostasis in taste buds , new cells are generated to replace dying cells.
To maintain telomere length ( TL ) and reduce its degradation after mitosis , the telomerase enzyme complex is produced.
To many people , old age appears to be a period of suffering and malaise.
To maximize compliance , adverse reactions to sunscreens should be minimized.
To maximize CoQ10 delivery to its biopharmaceutical target , numerous approaches have been undertaken.
To maximize functional improvements , the doses of anabolic hormones should be titrated to achieve target blood levels.
To maximize information gained from studies across the world , better harmonization of methodology is needed , as informed from current research practice.
To measure current QoL , for example , as an outcome measure , a simple single rating scale may suffice.
To measure endothelial dysfunction , ADMA concentration was assayed by high-performance liquid chromatography.
To measure subjective job demand , participants rated their job's demands within domains.
To meet our objective , we designed a cross-sectional survey study of pathologists ' clinical practices and perceptions.
To meet the health and economic challenges of aging populations , we must revive this Aristotelian vision of politics.
To meet the needs of this rapidly diversifying population , nurses need to be able to marry transcultural nursing knowledge with gerontological nursing knowledge.
To minimize adverse effects on glycemic control , prevention and management of general and oral complications in patients with diabetes are essential.
To minimize postoperative medical complications , duration of general anesthesia should be kept to a minimum.
To minimize selection biases resulting from a complex array of covariates , we implemented a generalized boosted model to generate propensity score weights on covariates.
To minimize the damage , IsoAsp can be \ "repaired \ " by a specific L-isoaspartate- ( D-aspartate )
To minimize the issue of potential misdiagnosis , we have also performed the analysis including only neuropathologically proven DLB cases ( @number@ cases ) .
To minimize the memory bias , the specific questionnaire on falls was completed only if the fall took place in the week preceding the contact.
To model the hypothesis that this downregulation is functionally significant , we genetically inactivated Junb in the prostate epithelium of mice.
To modify delirium risk , interventions were provided in cognitive stimulation , sensory improvement , and sleep promotion.
To monitor and evaluate the program , a cross-sectional postevent survey was conducted.
To monitor the clinical outcomes of DR interventions in humans , several biomarkers are commonly adopted.
To navigate the system and follow self-care protocols , patients must be able to understand and use health information , which requires health literacy.
Toneburst stimuli yielded significantly longer V , Na , and Pa latencies compared to clicks.
Tone-FFR phase coherence decreased as chronological age increased.
Tone-FFR phase coherence was significantly related to the later vowel response components but not the earlier vowel components.
Tongue-palate pressures and submental surface electromyography ( sEMG ) were simultaneously measured during swallowing of these same randomized liquids.
Tongue strength during swallowing yielded significantly greater anterior versus posterior tongue pressure.
Tonic phase duration also significantly increased with medication cessation , and although PGES durations increased , this was not significant.
To normalize the SEMG values amplitude ratios ( percentage of cumulated activity ) were calculated with respect to the specific limb.
Tonsillar B cells were then analyzed by flow cytometry.
To objectively define knowledge about vascular surgery , we administered a questionnaire to both a sample of the general population and medical students.
To observe the efficacy of intra-arterial chemotherapy with subcutaneously implanted pump for soft tissue sarcoma in extremities and cancerous ulcer.
To obtain a reasonable consensus is rather difficult.
To obtain a synthetic parameter describing local surface deformation , average curvature and curvature variability indexes were computed and compared.
To obtain contact hours you must : @number@
To obtain novel knowledge concerning these issues , we investigated the serum kinetics of sulfatide in @number@ adult kidney transplant recipients.
To obtain reliable results , both graft cells ( donor material ) and lymphocytes ( recipient material ) should be examined.
To obtain these patterns , many variables are aggregated to ensure the alert system reliability and minimize eventual false positive alert situations.
To obtain this clear phenotypic signature , about one hundred CD8 ( + ) T cells need to be measured.
Tool making evidences intelligent , flexible thinking.
Tools for pain assessment should be tested in older adult populations to establish reliability , validity , and sensitivity to changes from treatment.
Tools related to body structure and function included the visual analog scale , manual muscle testing , Penn Spasm Frequency Scale , and goniometry.
Tools that identify individuals at risk of falling can help reduce the risk of falling.
Tools that make preventative therapy more feasible on a large scale and in elders will help China achieve the global targets.
Tools to measure mobility were found to be either self-report or performance-based instruments.
Tools to predict course of disease in young children are a priority for families and clinicians.
Too many independent administrative bodies have been created , and many are less efficient than the public structures they replaced.
Too often , examples of aging or obsolete equipment , unit operations , processes , or entire facilities have been encountered.
To optimise care , clinicians should be familiar with the typical physiologic changes related to ageing and the implications for anaesthetic management.
To optimize care for stroke survivors , it is important to understand the amount of care that they receive and the implications for stroke caregivers.
To optimize healthy aging , interventions for smoking cessation should be tailored to men who have sex with men.
To optimize resource allocation , we aim to clarify the priorities of the functions of long-term care facilities from the viewpoint of future beneficiaries.
Tooth loss is a common health concern in older adults.
Tooth shades were assigned to four ordinal values.
To our best knowledge , this is the first reported and validated histological classification system intended for assessing histological degeneration in the cervical spine.
To our knowledge , it has not been reported previously nor has it been the subject of study.
To our knowledge no published study of LTL dynamics ( LTL and its attrition rate ) has corrected for this phenomenon.
To our knowledge , no research has studied the involvement of the partner in the decision-making process regarding breast reconstruction ( BR ) after cancer.
To our knowledge , no studies have examined the association between experiences of discrimination and CRP.
To our knowledge , no studies have yet examined dispersion in an aging HIV-infected sample.
To our knowledge , SHARE-FI represents the first European research effort towards a common frailty language at the community level.
To our knowledge , there are few publications analyzing the role of vitamin D3 in biological pathways existing in carcinogenic and neuropathological disorders.
To our knowledge , there have been few cases of CIED infection due to B. cepacia previously reported in the literature.
To our knowledge , the role of MT in skin ageing has not been reported.
To our knowledge this idealized geometric relationship , which assumes osteons are perfect cylinders , has not been rigorously explored.
To our knowledge , this is the first comprehensive analysis of a gp41 produced in eukaryotic cells including its immunosuppressive properties.
To our knowledge , this is the first demonstration that chronic stress-associated levels of CORT can reduce nucleic acid damage from oxidation.
To our knowledge this is the first description of microneedle enhanced skin permeation studies on these peptides.
To our knowledge , this is the first quantification of the rate and extent of submandibular gland ptosis.
To our knowledge this is the first report of this VP shunt complication.
To our knowledge , this is the first report providing genetic evidence linking GSAP to AD liability.
To our knowledge , this is the first review written on the use of dECM for improved mesenchymal stem cell expansion.
To our knowledge , this is the first study about the prevalence of SMC in Spain.
To our knowledge , this is the first study to compare respondents ' self-perceptions of successful aging among O-O relative to Y-O adults.
To our knowledge , this is the first study to investigate the long-term association of antioxidant supplement use and dementia incidence among asymptomatic men.
To our knowledge , this is the first study to suggest an association between sun exposure and cognition.
To our knowledge , this possibility has not been investigated in men.
To our knowledge , this report is the only anthropometric reference study in a normal oriental population.
To our knowledge , we demonstrate here for the first time that resveratrol induces the expression of SIRT1 protein in human cancer cells.
To our surprise , most of their body Sirtuin @number@ levels were between @date@ pg BDORT units.
To overcome the disadvantages of traditional ablative and non-ablative resurfacing , fractional photothermolysis ( FP ) has been introduced.
To overcome the limitations of both approaches , we developed a process-based novelty intervention using a card and board game-based training approach.
To overcome the limitations of current technologies , we developed and applied a novel , unbiased approach to identify lamin A-interacting proteins.
To overcome the problem , we added an extra step , training set modification , before training a classifier.
To overcome these difficulties , we developed a novel method to detect and enumerate CTCs with invasive property.
To overcome these difficulties , we present here three related methodological advances.
To overcome these limits , a European research group has explored the applicability of facial proportions as an age indicator on images.
To overcome these lymphomas that are intractable to existing treatment strategies , the tumor microenvironment has been identified as a potential therapeutic target.
To overcome this issue , we aimed to establish adequate ex vivo expansion protocols and identify repair modulators of cellular senescence.
To overcome this limitation , this paper presents a novel energy function based method for accurate and consistent sulcal parcellation of longitudinal cortical surfaces.
To overcome this partial coverage of ICF functioning categories , new assessment instruments have been developed.
To overcome this problem , we hypothesize that asymmetric information can be explored and exploited to improve the generalizability of the trained model.
Top3β binds multiple mRNAs encoded by genes with neuronal functions linked to schizophrenia and autism.
To particularly address this variability is a challenge for studies on lifetime trajectories from early to late adulthood.
To partition the effects of aging and falls efficacy on balance and leg strength simultaneously , canonical commonality analysis ( CCA ) was used.
To perform a meta-analysis of placebo-controlled clinical trials evaluating the anti-hypertensive effect of lactotripeptides assumed as nutraceuticals or functional foods.
To perform a systematic review and meta-analysis of risk factors for epilepsy during MS. Pubmed , Google scholar , and Scopus databases were searched.
Top findings were assessed for replication in a Norwegian cohort ( CONOR ) .
Top hits from fine mapping of the locus were in linkage disequilibrium of the index SNP.
Topical agents are frequently prescribed for elderly patients as first-line therapy because of their localized impact and minimal systemic effects.
Topical agents may provide benefit and are associated with fewer systemic side effects than oral administration.
Topical anesthetic cream was applied before the treatment.
Topical application of a folic acid- and creatine-containing formulation significantly improved firmness of mature skin in vivo.
Topical application of resveratrol ( RSV ) has been extensively studied owing to its multi-mechanistic skin anti-aging effects.
Topical application of these enzymes serves to supplement intrinsic DNA repair mechanisms.
Topical bleaching agents such as hydroquinone , kojic acid and azelaic acid can reduce signs of aging.
Topical DHEA cream stimulates local collagen production.
Topical intraocular pressure-lowering drugs must penetrate across the tissues of the eye to reach their therapeutic targets.
Topical minoxidil has been successfully used to treat androgenetic alopecia.
Topical nonsteroidal anti-inflammatory drugs ( NSAIDs ) should be considered ahead of oral formulations , and prescribing NSAIDs for older people requires careful consideration.
Topical NSAIDs are discussed as a viable therapeutic option.
Topical NSAIDs reduce systemic NSAID exposure and may mitigate these risks.
Topical @percent@ alpha lipoic acid ( ALA ) has shown efficacy in treatment of photo-damaged skin.
Topical photodynamic therapy is well-established procedure for the treatment of actinic keratoses , Bowen disease and basal cell carcinomas.
Topical retinoids , particularly tretinoin , are the most extensively studied.
Topical skin care regimens are a mainstay treatment for aging skin.
Topical therapy should always be adapted to patients ' age due to changes in skin physiology.
Topical treatment is the mainstay of therapy , providing special emphasis on skin hydration and barrier repair.
Topical treatments designed to increase the HA content of skin have been met with limited success.
Topical treatments with specific intermediate-size hyaluronate fragments ( HAFi , 50-400 kDa ) have been shown to stimulate keratinocytes proliferation and epidermal hyperplasia.
Topical tretinoin is used for the treatment of various dermatoses such as acne , melasma , scars , skin aging and non-melanoma skin cancer.
Topical use of anti-aging skin products is the most convenient and cheap way to achieve skin anti-aging effect.
Topic modeling , an unsupervised generative model , has been used to map seemingly disparate features to a common domain.
Topics were derived from white papers , funding announcements , or funded research projects relating to older adults with MCCs.
Topics were selected that represented developing or controversial areas that are important to care of increasingly frail older people.
Topics were subjected to systematic evidence review and top ten items were selected for appropriateness.
TopIII assumes a toroidal type 1A topoisomerase fold.
Topographical effects were analyzed using PCA.
Topographic patterns were analyzed by comparing the results according to age groups.
Topoisomerase IIIα ( TopIIIα ) together with RMI1 disentangles the final hemicatenane intermediate obtained once dHJs have converged.
Topoisomerases are crucial for solving DNA topological problems , but they have not been linked to RNA metabolism.
Top-performing linear combinations of @number@ and @number@ miRNAs have AUC of @number@.80-0.82.
To predict future QALY loss , future population projection data from the Korean Statistical Information Service were used as substitutes for @number@ population size.
To prevent adaptation , each subject performed only one trial , and a deception was used to ensure that the perturbation was truly unexpected.
To prevent and treat anemia better , a combination of the levels of Hb , Mg , and Fe in whole blood is required.
To prevent cancer , mammals have evolved potent tumor suppression mechanisms , including senescence and apoptosis.
To prevent chronic bladder ischemia caused by atherosclerosis and to treat its consequences , more pathophysiological knowledge is needed.
To prevent deleterious effects , damage is balanced by repair pathways.
To prevent early exit from work , sleep problems among aging employees need to be addressed.
To prevent falls , the reception conditions for sensory information need to be improved.
To prevent geriatric or disuse syndrome , JOA is currently providing the care prevention programs such as the loco-check and loco-training.
To prevent inflammation-associated damage , microglia reactivity is actively modulated by neurons in the healthy brain.
To prevent it , a new concept of \ "healthy aging \ " is arising from a healthy renal donor study.
To prevent or regulate protein aggregation , all cells contain an extensive protein homeostasis ( or proteostasis ) network comprising molecular chaperones and other factors.
To prevent PML development , sophisticated and well-organized strategies must be established for monoclonal antibody treatment.
To prevent the development of gastric cancer , eradication therapy should be administered early ( before the development of intestinal metaplasia ) .
To promote continuity of care for these persons after moving to a nursing home , a transfer intervention was developed.
To promote efficiency , a minimum set is needed for the diagnosis of malnutrition in the acute care setting.
To promote more extensive analyses , imaging data was designed to be compatible with other publicly available datasets.
To promote the development of psychiatric drugs with greater efficacy , we need to improve the way we bring potentially beneficial drugs to market.
To provide a more reliable estimate we conducted a meta-analysis of cohort studies to evaluate the potential role of RASSF1A promoter methylation in lung carcinogenesis.
To provide concise access to the complete information for a particular ageing factor , corresponding observations are also summarized on ageing factor pages.
To provide context , a recently conducted statutory gap analysis analyzing national emergency backup power trends is provided as a case study.
To provide fair comparisons across all the physical function measures , results were provided according to their increase in standard deviation ( SD ) .
To provide new insight into the mechanism by which mutant SOD1 induces motor neuron injury , we developed novel Caenorhabditis elegans models of ALS.
To provide such data , we surveyed @number@ cognitively normal research participants enrolled in a longitudinal study of aging and dementia.
To provide temporal adaptability to an agent , in this paper , we suggest a computational model for recognition memory that enables lifelong learning.
Top sources of energy and nutrients were identified.
Top ten foods contributing to each mineral were identified.
To quantify progression from overweight to obesity in a large contemporary cohort of children.
To quantify the candidates in the serum of NSCLC patients , mass spectrometry ( MRM-MS ) was performed for five candidate biomarkers.
To quantify the perinatal outcome and neurological morbidity in triplet pregnancies complicated by TTTS , which were treated with fetoscopic laser surgery.
To quantify the variability of the principal diffusion direction , bootstrap-derived metrics such as the cone of uncertainty have been proposed.
To quantitatively explore aging perceptions among elderly Turkish migrants , valid and reliable Turkish-language instruments are needed.
To reach a €50 @number@ per QALY cut-off , genotyping costs should be decreased towards €40 per test.
To realistically examine the link between cognitive lifestyle and cognitive decline , complex statistical models are required.
To realize its humble beginnings , one must become aware of the contributions by Black scholars who have a vested interest in the aging process.
To reduce pediatric obesity in clinical settings , multidisciplinary behaviorally-based treatment programs are recommended.
To reduce the impact of practice effects and of the menopause transition , we used the third cognition testing visit as the baseline.
To reduce the medication errors for the elder outpatients with chronic diseases , a cloud medication safety supporting system is designed , demonstrated and evaluated.
To reduce the potential for type II error in this pilot , p values < 0.10 were considered statistically significant.
To reduce the risk of circulatory collapse , the clinician should carefully titrate anaesthetics and await the response with patience.
To reduce the risk of heat-related injuries in these heat vulnerable individuals , it is necessary to identify interventions that can attenuate this impairment.
To reduce the treatment-related risks we do recommend a conservative approach for the unruptured aneurysms.
To regenerate this matrix , fibroblasts need to be stimulated into synthesizing new collagen.
To remain living with family had a negative effect on QoL score for the elderly.
To resolve protein misfolding , cells have evolved a collection of adaptive signaling pathways , called the unfolded protein response ( UPR ) .
To resolve this issue , here we report relative Actigraph intensity-thresholds for the elderly.
To restore protein clearance in HGPS cells , we treated HGPS cultures with sulforaphane ( SFN ) , an antioxidant derived from cruciferous vegetables.
To reveal the pathophysiological basis of the functional connectivity change , we performed magnetic resonance-diffusion tensor imaging.
To review the new role of an age-old micronutrient - ascorbic acid - in the management of periodontal disease.
Torin @number@ and PP242 were more \ "rapamycin-like \ " than Torin @number@ and AZD8055.
TOR intervenes in two distinct enzymatic complexes with different functions , a rapamycin-sensitive complex TORC1 and a rapamycin-insensitive complex TORC2.
TOR , named mTOR in mammals , is a conserved serine / threonine kinase that exists in two different complexes , mTORC1 and mTORC2.
Torque , muscle fiber conduction velocity and agonist-antagonist coactivation were measured during maximal voluntary contraction of knee extensors and flexors.
Torsades de Pointes ( TdP ) with syncope and convulsion were confirmed on ECG monitoring twice after admission.
To see the low sensitivity may from aging effect , the concentration of anti-CCP was analyzed for different aging group.
To segregate between target and masker sentences , ITDs from @number@ to @number@ µs were included.
To shed light on its biochemical role , we first studied the effects of its silencing on the mitochondrial oxidation of glucose and glutamine.
To shed light on the evolution of executive functions , we investigated the ontogenetic and phylogenetic origins of planning.
To single out the stages of autoimmune POI may allow a timely therapeutic choice in the subclinical and early clinical stages.
To smaller @number@ checks , peak latencies were earlier and C2 became more obvious.
To solve this limitation , for the first time , we developed a novel polymeric valve whose leaflets possess calcium hydroxyapatite inclusions immersed in them.
To some extent , these results diverge from previous findings and need to be reassessed in future studies.
To specifically address the pathogenesis of this mutation , we created NBC1 W516X knock-in mice to match the patient's abnormalities.
To specify the value of oVEMP in the diagnostics of Menière's disease , the amplitude ratio between @number@ and @number@ Hz stimuli was investigated.
\ "To stay still or not to stay still \ " is the underlying question in functioning and disability in old age.
To study and understand the aging effect , two batches of Metformin HCl manufactured at different periods of time were selected.
To study the age of RBCs , we classified transfused patients into quartiles according to the age of oldest transfused RBC unit in the ICU.
To study the force generation by CSMC , three-dimensional colonic rings were bioengineered.
To study the genetics of memory and memory-related diseases , hippocampal functioning has served as an intermediate phenotype.
To study the possible involvement of epigenetic changes in somatic stem cell aging , we used murine hematopoiesis as a model system.
To study whether these differences precede cognitive decline in the elderly.
To successfully apply them , a number of issues regarding assessment and implementation of SCD needed to be addressed.
To summarize the recent progress in the field , a literature search was conducted in PubMed and Web of Science.
To sum up , amniotic cells are a promising source in the treatment of burns and can be used as a hospital exemption.
To support user centred development of life support robots the ULCEAT method was developed.
To suppress the level of GSK-3β , SAMP8 mice were treated with an antisense oligonucleotide ( GAO ) directed at this kinase.
To survive , the human population should genetically be reorganized according to these changes.
To take account of the role of social policies , we adopt a comparative approach.
To take distance into account , the two treatment groups were compared within distance strata using two-way analyses of variance ( ANOVAs ) .
To take into account the effect of basic multicellular units ( BMUs ) , a set of computational algorithms has been developed.
Total 25 ( OH ) D was measured in non-fasting serum samples with an enhanced chemiluminescence immunoassay.
Total activity by actigraphy did not correlate well with self-reported activity.
Total activity volume and number of health care facilities involved were highly variable in the different regions.
Total adiposity was measured by whole-body dual-energy X-ray absorptiometry and regional adiposity by abdominal and thigh computed tomography scans at baseline and 5-year follow-up.
Total ADL score was mainly determined by mobility , while total IADL score was mainly determined by level of ID.
Total aggregate inpatient days is projected to increase @percent@ more than population growth.
Total AMS score increased [ MAD 9·35 ( 5·65 , 13·07 ) , P < 0·001 ] , reflecting worse QoL.
Total and cortical bone volumes and medullary cavity volumes ( mm ( @number@ ) ) were calculated at proximal and distal sites for both bones.
Total and free thyroid hormones , TBG , and TSH were determined using immunoassays.
Total and free T levels were measured by liquid chromatography-tandem mass spectrometry and equilibrium dialysis , respectively.
Total and HMW adiponectin were measured in @number@ subjects without prevalent HF , atrial fibrillation or CVD.
Total and regional cerebellar GMV was measured on 3T-magnetic resonance imaging.
Total and trial-to-trial performance on the storage , retrieval , repeated retrieval , and ineffective reminder indices were assessed.
Total antioxidant capacity of the formulation , estimated by FRAP was @number@ ± @number@ μM Fe ( II ) / g dry mass.
Total barrier score and health barriers significantly predict a participant's dropping out , and white ethnicity is associated with a higher likelihood of dropping out.
Total blood leukocyte and neutrophil samples were collected.
Total body fat and water percentages were determined via bioimpedance at @number@ KHz.
Total % body fat was assessed by dual-energy X-ray absorptiometry , and intra-abdominal adiposity ( IAAT ) by computed tomography.
Total body FM was an independent determinant of walking speed , while fat-free mass and lean-to-fat ratio were not.
Total brain , gray matter , and hippocampal volume were estimated using voxel-based morphometry , and annualized change in brain volumes was calculated.
Total brain volume and a further seven regions were assessed , including lobar volumes , lateral divisions , and separated grey and white matter.
Total brain volume ( BV ) and the volumes of brain substructures are influenced by genes , the magnitude of which changes with age.
Total brain volume ( TBV ) and volumes of structures affected in later AD were examined for comparison.
Total brain volume was also positively associated with verbal learning , but not with verbal recall.
Total carbohydrate intake was not associated with risk of adiposity-related cancers combined or prostate and colorectal cancers.
Total CBF was determined in each scan and also standardized for brain parenchymal volume.
Total cerebral blood flow was defined as BFR in the internal carotid plus vertebral arteries and mean cerebral perfusion as tCBF / brain volume.
Total cf-DNA was quantified directly in plasma and the amplifiable cf-DNA was assessed using quantitative PCR.
Total cholesterol declined in old age , and low cholesterol was associated with poor health and multi-morbidity.
Total cholesterol , hepatosomatic index , Nrf2 , antioxidant , and inflammation markers were determined.
Total cholesterol / high-density lipoprotein cholesterol ( TC / HDL-C ) and low-density lipoprotein / HDL-C ratios were used as biomarkers of CVD risk.
Total CK levels were elevated for all participants at all time points post-race ( P < @number@ ) .
Total coherence resulted lower in pre-CO₂ and post-CO₂ and presented poor reactivity during CO₂ inhalation in MCI patients compared with Nold subjects.
Total costs were divided by the number of classes being offered by each agency to determine cost per class per month.
Total Cronbach's α coefficient was @number@
Total daily activity declined @percent@ more rapidly for each additional year of age at baseline ( estimate @number@ S.E. @number@ p = 0.027 ) .
Total daily activity modified the association between WMH and motor function ( p = @number@ ) .
Total diet scores were allocated for intake of selected food groups and nutrients for each participant as described in the Australian Guide to Healthy Eating.
Total direct costs attributable to osteoporosis amounted to €728 million in @number@
Total drinking water was the sum of plain water and beverages.
Total E ( @number@ ) level , though related to muscle mass positively , affected muscle strength adversely in older men.
Total erections rose to a maximum over @number@ weeks and then plateaued.
Total error between DXA-derived aLM and TMM ( ∼2 kg ) was lower compared with the three other selected equations ( 6-10 kg ) .
Total fat mass was acquired from dual energy X-ray absorptiometry.
Total fat , PUFA , and trans-fat intakes were not associated with cognitive trajectory.
Total flow through the major cerebropetal arteries was unchanged in both young and old.
Total free fatty acids , insulin , glucose , triglycerides , and cholesterol as well as several inflammatory cytokines were measured in plasma.
Total ghrelin levels are decreased after meals , irrespective of pubertal stages in obese children and adolescents.
Total heat loss ( evaporative ± dry heat exchange ) and metabolic heat production were measured using direct and indirect calorimetry , respectively.
Total hepatic clearance of substances mediated by these enzymes may mature concurrently or take longer because of other physiological factors.
Total hip and total body BMD were assessed with dual-energy X-ray absorptiometry at baseline , @number@ and @number@ months.
Total hip arthroplasty is increasing in incidence due to our aging population.
Total hospital charges were similar , although slightly higher in the propofol group.
Total hyperemia increased significantly in both groups.
Total hyperuricemic prevalence was @time@ % , with male significantly higher than female.
Total IGF1 tended to decrease more with age compared with bioactive IGF1 ( @number@ vs @number@ percent / year , P = 0.052 ) .
Total IIEF-5 score was @number@ ± @number@ in group @number@ @number@ ± @number@ in group @number@ and @number@ ± @number@ in group @number@
Total intracranial volume is TBV plus cerebral spinal fluid ( TICV ) .
Total ischemic lesion volumes increased in both arms at a rate of @number@ cm ( @number@ ) / y ( p = @number@ ) .
Total joint arthroplasty offers pain relief and potential functional improvement.
Total joint arthroplasty ( TJA ) is commonly performed on older adults.
Total levels ( bound plus free ) of active MMP2 and @number@ were significantly reduced in AMD donors ( P < @number@ ) .
Total levels can be obtained in extracts of cell populations by immunoblot analysis , and in cell populations by flow cytometry.
Totally covering a human being , it acts as a protector throughout its lifetime , without ever being protected itself.
Totally , @number@ eyes of @number@ healthy volunteers were studied in a tertiary care center.
Totally @number@ patients came from the schistosomiasis endemic areas ( @percent@ ) and @number@ patients from non-schistosomiasis endemic areas ( @percent@ ) .
Totally , @number@ ( @percent@ ) complications were recorded.
Total MMSE performance correlated significantly with a minority of neuropsychological tests and MRI-derived indices of white matter disease and brain atrophy.
Total MNA scores were significantly lower in cases with acromegaly than in the CG ( p = @number@ ) .
Total mortality includes death from external causes.
Total mortality was also increased ( @number@ [ @number@.2-3.3 ] ) .
Total MS prevalence by consensus criterion was much higher than by CDS criterion ( @percent@ versus @time@ % ) .
Total , muscular , and fat cross-sectional areas of the calf and relative muscle density were measured using peripheral quantitative computerized tomography.
Total number of patients was @number@
Total @number@ participants ( @percent@ ) reported difficulties and / or disability in performing activities of daily living ( ADL ) at follow-up.
Total peripheral resistance index decreased in proportion to the magnitude of HDT and recovered over the first @number@ s of HUT.
Total prostate volume ( TPV ) and transition zone volume ( TZV ) were measured by transrectal ultrasonography.
Total protein extracts were then compared by two-dimensional difference in gel electrophoresis ( 2D DIGE ) .
Total psychosocial adversity in childhood was not associated with cognitive capability.
Total QOL was better for the group discontinuing statin therapy ( mean McGill QOL score , @number@ vs @number@ P = .04 ) .
Total recall index is not associated with chemotherapy.
Total recruitment was @number@
Total RNA from whole blood was processed on human whole genome Affymetrix HU133 Plus @number@ microarrays.
Total RNA of three individuals of defined age were pooled and analyzed by SuperSAGE ( serial analysis of gene expression ) .
Total RNA was extracted and analyzed using DermArray ( ® ) cDNA microarrays.
Total RNA was extracted from tissue samples and further analyzed by real-time RT-PCR.
Total RNA was isolated and reverse-transcribed.
Total score did not reflect the action of a single underlying construct but rather appeared to index a number of factors.
Total score ranged from @number@ to @number@ ( mean @number@ ± @number@ ) .
Total secretion correlated negatively with free T₄ ( R = @number@ P = @number@ ) .
Total serum T < @number@ ng / dL was used as the threshold for biochemical T deficiency.
Total sleep time , sleep onset latency , and wake after sleep onset were also estimated with actigraphy.
Total sleep time ( TST ) and wake after sleep onset ( WASO ) tertiles were our primary predictors.
Total SMM was estimated from ultrasound-derived prediction equations.
Total sperm count , progressive motility , and sperm DNA fragmentation were analyzed in sperm , and metabolic assays were performed on blood.
Total T3 was not associated with any outcome.
Total tau can be used as a diagnostic test for the assessment of prion protein type when codon @number@ genotype is known.
Total testosterone levels were positively associated with JPA in anterior leads ( β = @number@ p < 0.05 ) in women.
Total testosterone ( T ) and oestradiol ( E ( @number@ ) ) were measured by mass spectrometry and the free and bioavailable fractions calculated.
Total testosterone was measured in serum by LC-MS / MS , and free testosterone levels were measured by equilibrium dialysis.
Total testosterone was positively associated with anterior electrocardiographic lead JPA in women ( β = @number@ p < 0.02 ) , but not in men.
Total tissue volume ( TTV ) and gray matter cerebral blood flow ( GM-CBF ) were estimated using 3T brain MR images.
Total variance explained was @percent@.
Total volume of pneumonia was added up after manual measurement of each lesion , followed by statistical analysis.
Total volumetric BMD ( vBMD ) at @percent@ of the tibia length was significantly lower ( p < 0.05 ) in older men.
Total white blood cell TL was measured by TRF-Southern technique.
To target APRIL therapeutically , we developed two anti-human APRIL antibodies ( hAPRIL.01A and hAPRIL.03A ) that block APRIL binding to BCMA and TACI.
To target muscle anabolism it is suggested that higher postprandial blood levels of leucine and EAA are needed in older people.
ToTelvysion kit ( Abbott Molecular , Abbott Park , IL , USA ) with telomere-specific probes was used.
To test construct validity , we evaluated the shape of the CP-FI-CGA distribution , including its maximum value , relationship with age and gender.
To test for construct validity , group comparisons were implemented.
To test for evidence of gene-gene interactions and genotype-phenotype relationships , pooled data were analyzed.
To test for replication , two approaches were implemented.
To test for time trend , we fitted Poisson regression models.
To test generalisability of these concepts , they were applied to data from an Australian study of people using disability personal support.
To test our hypotheses we make use of the fourth wave of the European Values Study , and the MULTILINKS Social Policy Indicators database.
To test our hypothesis , an exploratory latent class analysis and multivariate logistic regression were used.
To test the hypothesis , participants ( n = @number@ age , 65-92 years ) did 3-day weighed food records and reported physical activity.
To test the potential of SMN as a modifier of ALS , we overexpressed SMN in @number@ different strains of SOD1 ( G93A ) mice.
To test the role of AMPK-mTOR signaling , siRNA was used to deplete AMPK.
To test the role of Gank in degradation of CUGBP1 , we generated mice with liver-specific deletion of Gank.
To test these predictions , we present here the analysis and modeling of ( @number@ ) F-PBR111 data in healthy humans.
To test these proposals , we developed a single-molecule technique for visualizing encounters of replication forks with ICLs as they occur in living cells.
To test the significance of these data in humans , telomere biology in circulating leukocytes of young and middle-aged track and field athletes was analyzed.
To test the stability of learning preferences , the task involved a reversal phase in which stimulus-response assignments were inverted.
To test this hypothesis , the authors investigated the mucin in the legs of aged individuals without any dermatologic disease.
To test this hypothesis , we examined muscle spindles in the young masseter muscle and compared the result with previous data on adult masseter spindles.
To test this hypothesis , we examined the cross-sectional associations between individual bioavailable sex hormones and SHBG with radiographically assessed kyphosis.
To test this hypothesis , we investigated the genome-wide methylation profile in @number@ Chinese female centenarians and @number@ middle-aged controls using methyl-DNA immunoprecipitation sequencing.
To test this hypothesis , we investigated the response latency to yes-no questions pertaining to familiar and unfamiliar objects in 3- to 6-year-olds.
To test this hypothesis , we screened @number@ idiopathic PD patients and @number@ control subjects for mutations in the retromer subunit VPS26A.
To test this hypothesis , we transduced tumor and normal cells with a lentivirus encoding Δ40p53.
To test this , we followed mice with a targeted mutation ( Col1a1 ( r / r ) ) that yields collagenase-resistant type I collagen.
To test this , we increased serum anti-ceramide IgG ( 2-fold ) by ceramide administration and analyzed amyloid plaque formation in 5XFAD mice.
To that end , recent studies have already linked the circadian clock to psoriasis , one of the most common immune-mediated skin disorders.
To that end , we propose the Spectrum Model of Aging.
To that end , we report the development and psychometric testing of a nursing home palliative care survey.
To the authors ' knowledge , interventions to prevent or remediate frailty among childhood cancer survivors have not been tested to date.
To the authors ' knowledge , this is the first study of women's knowledge about fertility , aging , and their health literacy.
To the author's knowledge this is the only plausible and self-consistent mechanism to explain CICI.
To the best of our knowledge , available information on the appropriateness of lipid-lowering treatment is extremely limited.
To the best of our knowledge , the elastography appearance of muscles in normal children has not been described.
To the best of our knowledge , there are no reported studies that performed detailed identification and validation of NLRP1 inflammasome during the epileptogenic process.
To the best of our knowledge , this has not yet been studied in detail in the literature.
To the best of our knowledge , this is the first report of the application of computer technology to grading of nasolabial folds.
To the best of our knowledge , this is the first report suggesting that LHCGR genetic variation might function in patient risk for OHSS.
To the best of our knowledge , this study provides the first evidence for a significant increase in fear-potentiated startle across the pubertal transition.
To the contrary , measures such as caloric restriction and exercise may promote autophagy to delay aging and associated comorbidities.
To the contrary , progressive ageing seems not to be significantly related to elevated adiponectin levels within Caucasians.
To the extent that cross-sectional and longitudinal effects of age differ , obtained estimates of aging and retest may not be informative.
To the naked eye , a person \ "quiet standing \ " on a rigid surface of support is stationary.
To this aim , @number@ centenarians were concomitantly characterized for their immunological , health and functional status , and followed-up for five-year survival.
To this aim we studied an animal model expressing the pathogenic human FTL mutant 498InsTC under the phosphoglycerate kinase ( PGK ) promoter.
To this area the author groups provided some initial efforts.
To this day , the authors maintain that for isolated filling of lips and nasolabial folds , off the- shelf fillers are a better alternative.
To this end , 2-months-old male SAMR1 and SAMP8 mice were fed a Western type diet ( control groups ) for @number@ months.
To this end , animal models of stress exposure in rodents during their post-weaning and pre-pubertal life phase have been developed.
To this end , cRNA encoding KCNQ1 / KCNE1 was injected in Xenopus oocytes with or without additional injection of cRNA encoding Klotho.
To this end details are also provided of clinical trials currently listed in the main clinical trials database to highlight research areas of particular interest.
To this end , hMSCs were administered intravenously to APPPS1 transgenic mice that normally develop cerebral Aβ.
To this end , pharmacological manipulation of the endogenous cannabinoid system , as well as application of phytocannabinoids and synthetic cannabinoids have been investigated.
To this end , psychometrically sound instruments are required to advance cross-national research.
To this end , we analyzed whole-exome sequencing data of eight chronic lymphocytic leukemia ( CLL ) patients that developed resistance upon BCL2-inhibition by venetoclax.
To this end , we applied unilamellar transfer liposomes , which provided protection from oxidation and effective incorporation of DHA into cell membranes.
To this end , we assessed the urinary excretion levels of 6-sulphatoxymelatonin ( aMTS6 ) , a major metabolite of melatonin.
To this end , we characterize the behavioral , biochemical , and neuropathologic effects of 8ISO in the triple transgenic mouse model.
To this end , we have generated mice conditionally deleted for the shelterin proteins TRF1 , TPP1 and Rap1.
To this end , we tested the rTg4510 mouse model on a behavioral battery that included amygdala-dependent tasks of exploration.
To this extent , we searched for markers that are elevated in melanoma and are under regulation of potentially druggable enzymes.
To this extent , we suggest that HIF can also be described as a hyperglycemia-inducible factor.
To this purpose , @number@ patients enrolled in five consecutive Italian clinical trials were retrospectively analysed.
Touch-screen technology was used as a platform for user interaction.
Touch sensitivity at different body locations were tested by using von Frey monofilaments.
Touch-up injection was performed in @percent@ of subjects mainly for the eyebrow asymmetry.
Touch-ups were allowed for optimal correction.
To understand further the neural basis of these phenomena , we used a new task that manipulated the options to repeat responses.
To understand how physical activity in the elderly affects endogenous Q10 levels in blood plasma , we studied a cohort of healthy community-dwelling people.
To understand how the miR-155 controls thiamine level , a set of key molecules for thiamine homeostasis were further analyzed after the knockdown of miR-155.
To understand how to improve the safety of octogenarians ' aging-in-place , a systems approach is essential.
To understand mechanisms whereby ET-1 induces vascular damage , vascular gene expression profiling was performed using DNA microarrays.
To understand the biological impact of accumulating spontaneous DNA damage , we studied the phenotypic consequences of DNA-repair deficiency in Caenorhabditis elegans.
To understand the clinical relevance of our early results it will be mandatory to extend the observation to other clinical and neuropathological series.
To understand the full physiological impact of Caspase-6 in humans , we investigated Caspase-6 expression.
To understand their contextual experience of aging , we interviewed participants in the Boston Puerto Rican Health Study.
To understand the pathophysiology underlying the vascular lesions in CCM , it is critical to develop a reproducible mouse genetic model of this disease.
To understand the underlying mechanisms of the well-established SNARC effect , it seems essential to explore the considerable inter-individual variability characterizing it.
To understand the underlying mechanism , we investigated the cellular and functional consequences of LRP1 deletion in primary neurons.
To understand the underlying molecular pathology of HGPS , we derived induced pluripotent stem cells ( iPSCs ) from HGPS dermal fibroblasts.
To understand this relationship it is necessary to be clear about the evolutionary forces acting on both sets of factors.
To understand why vulnerable women defend more privileged citizens of the nation , I address Mexicana subjectivity.
To unify these disparate theories and data , here , we propose the epigenetic oxidative redox shift ( EORS ) theory of aging.
To unravel a possible different mechanism underlying dilation in bicuspidy and tricuspidy , a comparison of the structure of the aortic wall was made.
To update previous U.S. estimates of doctor-diagnosed arthritis and AAAL , CDC analyzed National Health Interview Survey ( NHIS ) data from @number@ @number@
Tourette's syndrome ( TS ) is a developmental neuropsychiatric disorder characterized by motor and vocal tics as well as psychiatric comorbidities.
To use lay definitions in studies of aging , however , researchers must address the definitions ' consistency.
To validate the association between rs1344706 and schizophrenia , further studies with larger participant populations worldwide are needed.
To validate the system after development , this study conducted an experiment and employed a questionnaire to survey users.
To validate this optimization scheme under realistic conditions , we use the Alzheimer's Disease Neuroimaging Initiative cohort.
To view the other articles in this section visit @url@
To view the other articles in this section visit @url@
To view the other articles in this section visit @url@
To view the other articles in this section visit @url@
Towards discussions at the next ISSAM / ESSAM meeting in Moscow , @date@ , we suggest the following update.
Toward the end of the movement , younger adults showed higher synergy indexes than older adults.
Toward this end , the current study seeks to evaluate the prior and current geriatric experiences and perspectives of hematology / oncology fellows.
Toward this objective , we performed a literature search in PubMed and Ovid with limits to articles published in the English language before @date@ .
To what extent does our visual-spatial attention change with age ?
To what extent might this limit or , alternatively , open up the possibilities for sexual expression and subjectivity in later life ?
To what extent these HIF-dependent and HIF-independent functions cooperate in VHL-defective tumorigenesis remains to be determined.
To what extent this is also reflected in the juvenile Inuit population is unknown.
Toxic effects of aggregated tau and / or dysfunction of soluble tau could both contribute to neural defects in these neurodegenerative diseases.
Toxicity among the prophylactic group was not statistically significantly different from that of the non-prophylactic group.
Toxicity manifests as motor impairment and a shortened lifespan.
Toxicity studies indicated that A. bidentata and A. aspera seem non-toxic at the common therapeutic doses.
Toxic metals ( Cd , Pb ) seemed to negatively affect the level of bioavailable testosterone.
Toxic metals were found to contribute to cognitive decline and also to influence ALA-D reactivation.
Toxicodynetics showed that nordiazepam is not a cause of coma even in large overdose while oxazepam causes coma only at a very high dose.
Toxoplasma genomic DNA genotyping demonstrated a common genetic character of Chinese @number@ indicating a possible pathogenic origin of animals in human infection.
Toxoplasma gondii ( T. gondii ) seropositivity may be associated with decreased memory in older adults.
TP53 overexpression is indicative of somatic TP53 mutations and associates with aggressive tumors and poor prognosis in breast cancer.
TPA-induced phosphorylation of p38 , JNK1 / 2 and Akt was also suppressed by DGC.
TPC is reliable procedure for management intractable bilateral SSP.
T-pos seniors showed an impairment of different aspects of memory.
TPP-1 was separated from the TPP by Sephadex G-100 column chromatography.
TPP2 deficiency is the first primary immunodeficiency linking premature immunosenescence to severe autoimmunity.
TPP2 is a serine exopeptidase involved in extralysosomal peptide degradation.
TPPII and SIRT6 directly affect glucose metabolism which drive malignant growth.
Tpr has been since implicated in a variety of nuclear functions , including nuclear transport , chromatin organization , regulation of transcription , and mitosis.
Tpr is a prominent architectural component of the nuclear pore complex that forms the basket-like structure on the nucleoplasmic side of the pore.
TPR is considered to be decreased by agents for treatment of hypertension , and meal ingestion does not appear to further decrease TPR.
TPs had lower low-density lipoprotein cholesterol but higher high-density lipoprotein cholesterol than BFs ( P < 0.01 ) .
TPs were shorter ( P = 0.02 ) with lower body weight ( P < 0.01 ) in comparison with contemporary pygmies and BFs.
TQ Green imaging can also resolve the changes in GSH concentration in PANC-1 cells upon diethylmaleate ( DEM ) treatment.
Trabecular bone is a metabolically active tissue with a high surface to volume ratio.
Trabecular bone loss was already evident in young adulthood and continued throughout life.
Trabecular but not cortical and subcortical vBMD was also higher ( @percent@ , p = @number@ ) .
TRAb-negative GD patients had biochemically mild thyrotoxicosis.
Tracer methodology now permits estimation of DHA half-life in the human brain and whole body.
Tracer uptake was evaluated visually and analyzed voxel by voxel over the entire brain to investigate the spatial distribution of amyloid deposition.
Tracking a digital pursuit rotor task was used to measure dual task costs of language production by young and older adults.
Tracking and CoM response delays remained constant , however , at @number@ s and @number@ s , respectively.
Tracking behavior early in a change attempt may identify prognostic patterns of change and facilitate adaptive treatment planning.
Tracking performance improved when they were rewarded for tracking and declined when they were rewarded for talking.
Tracking studies have often had limited follow-up lengths.
Tracking the subsidising influence of external support can help blood services make strategic investments and plan for unit price increases as external funds are withdrawn.
Tract-based spatial statistics analysis was also performed to investigate the deeper white matter tracts.
Tract-based spatial statistics was used to process DTI data.
Tract-Based Spatial Statistics was used to study thalamic diffusion differences between groups.
Tractography of diffusion-weighted images suggested that these @number@ regions have a different set of connections but may exchange information via the arcuate fasciculus.
Tract-specific characteristics were calculated using Matlab.
Tracts were delineated from diffusion magnetic resonance images using probabilistic tractography.
Traditional and fractional ablative resurfacing induces skin tightening through precise dermal heating and a wound-healing effect.
Traditional and recent digital signal processing tools were employed for feature computation from the displacement of the COP.
Traditional anesthesia consultation captures only a small portion of the necessary information , especially about functional status and frailty.
Traditional assays for the measurement of elastin and fibrillin-1 , such as western blotting , Luna staining and immunostaining , are relatively complex and time-consuming.
Traditional beliefs shaped caregivers ' needs ; also , ethno-cultural-linguistic contexts affected system usability and were associated with usage behaviour.
Traditional body sway measures are unable to describe underlying postural control mechanism.
Traditional cardiovascular risk factors were highly prevalent ( hypertension @percent@ , diabetes @percent@ , dyslipidemia @percent@ , nicotine use @percent@ ) .
Traditional Chinese Medicine approaches have been employed for thousands of years to relieve knee osteoarthritis pain.
Traditional Chinese medicine ( TCM ) is focused on , which can provide new strategies for the therapy in neurological disorders.
Traditional concepts focused on either efferent innervation or myogenic dysfunction.
Traditional CVD risk factors were associated with subclinical atherosclerosis.
Traditional diagnosis is not able to screen all the variety of xenobiotics and potential human diseases.
Traditional EMS systems were designed to treat single acute conditions ; this approach contrasts with best practices for the care of frail older adults.
Traditional gait training generally fails to fully address these complex gait activities.
Traditional life-cycle models unambiguously suggest that the borrowing option makes people better off than not being able to borrow.
Traditional linear regression models assume a constant relationship between brain structure and cognition over time.
Traditionally , adherence to PA recommendation is assessed by accelerometers that record absolute intensity thresholds.
Traditionally , adipocytes within tissues were thought to act as reservoirs of energy , as thermal , or as structural support.
Traditionally , ALM was believed to have a poorer prognosis than other subtypes of cutaneous melanoma because of its aggressive behavior.
Traditionally , antioxidant products are exogenously provided to neutralize pro-oxidant species.
Traditionally , autophagy assessment relies on the measurement of LC3-II protein levels or the visualization of LC3-positive puncta.
Traditionally catch-up was thought to be complete in the first few years of life.
Traditionally , education on domiciliary dental care in the elderly is not provided at the college level.
Traditionally , Germany has a weak primary care system.
Traditionally , neuroprotection strategies were designed to improve stroke outcome by interfering with pathological processes triggered by ischemia.
Traditionally open repair has been recognized to offer a lower rerupture rate compared with nonoperative methods but with a higher complication rate.
Traditionally , sensory and motor dysfunctions in aging and AD have been studied separately.
Traditionally , soft tissue lifting and redraping have constituted the cornerstone of most facial rejuvenation procedures.
Traditionally , the high prevalence of dyslipidemia in elderly people is considered a \ "natural condition. \ "
Traditionally , these two pathways have been viewed largely in isolation.
Traditional matrilocal residence patterns contributed to the perceptions of the older persons.
Traditional measures of sway speed and magnitude were not significantly lower among TC-experts.
Traditional mentoring focuses on sponsorship and coaching.
Traditional nucleic acids preservation methods rely on maintaining samples in cold environments , which are costly to operate and time sensitive.
Traditional physical activity interventions do not consider the specific needs and views of older adults.
Traditional predictors ( age , stroke length , pre-therapy upper limb clinical impairment , infarct volume ) were also investigated.
Traditional risk factors have no mediator role.
Traditional strategies for nonpharmacological treatment of late-life depression do not specifically address the co-occurring cognitive impairment and disability that is prevalent in this population.
Traditional teaching has focused on excision and tightening of the pathologic muscle with subsequent removal of excess skin.
Traditional theories on facial aging and methods for rejuvenation focus primarily on soft tissues with ptosis as the major mechanism responsible for senescent changes.
Traditional trauma fellowships have now transitioned into Surgical Critical Care or Acute Care Surgery ( trauma , surgical critical care , emergency surgery ) fellowships.
Traditional view holds that stem cell aging contributes to the senility of body and organs.
Traditional views on facial aging and associated therapies focused on soft tissue descent and skin texture changes.
Tradition considers that mammalian heart consists of about @percent@ non-myocytes ( interstitial cells ) and @percent@ cardiomyocytes ( CMs ) .
TRAF6 also possesses E3 ubiquitin ligase activity causing lysine-63-linked polyubiquitination of target proteins.
Traffic pollution may decrease parasympathetic tone among diabetic elderly.
Trail-Making Tests A and B were also incorporated , with cognitive decline defined as discontinued testing or the worst @percent@ of change from baseline.
Trail Registration : ClinicalTrials.gov , NCT # 00977418.
Trained assistants performed medical record review to obtain patient characteristics.
Trained Community health workers delivered the 10-week programs.
Trained groups were subjected to walking exercise involved @number@ sessions per week for @number@ months.
Trained interviewers collected data on selected socioeconomic and demographic characteristics , lifestyle habits and other personal and familial factors.
Trained lay interviewers assessed mental disorders based on Diagnostic and Statistical Manual of Mental Disorders - 4th Edition ( DSM-IV ) criteria.
Trained older adults showed higher performance than did controls on the criterion task and maintained this benefit after @number@ months.
Trained panelists found higher musty and putrid flavors for dry-aged muscles closer to exterior surface.
Trained physician counselors provided free individual counseling and follow-up interviews with brief counseling for all the subjects.
Trained professional and elder lay leaders facilitated participants to gain essential self-management knowledge and skills for the effective management of chronic diseases.
Trained research assistants assessed the outcome measures at the beginning of the rehabilitation program ( baseline ) and at a 4-month follow-up.
Trained research assistants observed medication administration passes and performed participant interviews after each medication pass.
Trained research personnel administered the AD8 to informants.
Trained staff used a comprehensive geriatric assessment questionnaire and a standard survey instrument to complete the assessments.
Trained staff were assigned to between-meal supplement or snack delivery for the intervention group ; the control group received usual care.
Trainees ' gender , ranking of their school , type of research , and specific content of research project did not predict improvement.
Trainees in China rate educational experiences and mentorship more highly , whereas U.S. trainees rate altruistic goals more highly.
Trainees ( @percent@ female ; mean age @number@ ) completed a pretest questionnaire and a posttest administered by mail.
Training adherence resulted in greater training effects.
Training affected several DTI metrics and increased the area of the anterior part of the corpus callosum.
Training aids that compensate for cognitive impairments may be essential for achieving effective glucose control.
Training and career satisfactions remain high as well.
Training and experience in the art and science of fillers is essential for the successful creation of a more youthful and natural appearance.
Training and resource in the sector should reflect this.
Training attenuated this difference.
Training caregivers to recognise signs of frailty is essential.
Training consists on imagery motor exercises combined with memory and logical relation tasks.
Training did not significantly impact MEP ( p = @number@ ) or H-reflex amplitudes ( p = @number@ ) .
Training gains and transfer effects were also assessed after @number@ months.
Training gains were significantly larger in the training group than in the control group in only two of those tasks.
Training-induced favorable adaptations were reversed during detraining but , eventually , training groups presented better values than the control group even after detraining.
Training is designed to have participants perform diverse exercises in one or more cognitive domains.
Training lasted @number@ weeks , with sessions held three times a week.
Training may significantly increase pain-free walking time ( + @number@ % ) while avoiding the associated complications of ( repeated ) invasive revascularization.
Training programmes that specifically target these measures may be effective in improving balance recovery performance and thereby contribute to fall prevention amongst older adults.
Training requires large and representative data sets of segmented hippocampi.
Training resulted in a reduction of upper body rotation and an increase of shank rotation and center of pressure displacement.
Training resulted in enhanced discrimination abilities in the setting of irrelevant information in both species that was driven by selectively diminished distraction-related errors.
Training should be provided to patients to enhance their communication abilities.
Training should focus on individuals with low health literacy who may be less likely to receive sunlight exposure.
Training stimuli appeared in text-only format in half of the sessions and text with a color photograph of the country in the other sessions.
Training the models only on patients , produced more than @percent@ patients correctly discriminated as ALS or PD type and maximal performances for multi-view models.
Training to volitional fatigue might be necessary to obtain optimal results.
Training volume ( km·wk , d·wk ) decreased in both the men and women.
Training was found to be adequate for @percent@ of the sample.
Training was performed on a cycle-ergometer three times per week for @number@ min at ~70% of VO ( @number@ peak ) .
Training was performed twice a week and was designed to load bones with intermittent and multidirectional compressive forces and to improve physical function.
Training will include lying position , turning body , sitting position , crawling , kneeling and standing position , walking and so on.
Trait-like aspects of the sleep EEG were observed for sleep stage variables and spectral power.
Traits are not regulated independently but vary simultaneously ( ie , covary ) in specific ways to establish function.
Traits that facilitate competition for reproductive resources or that influence mate choice generally have a heightened sensitivity to stressors.
Trajectories of BMI and FFMI did not differ between the sleep duration categories.
Trajectories of new subject's data are estimated when using no observation , only the first or the first two time points.
Trajectories of nutritional status were significantly associated with cognitive-function trajectories.
Trajectories of social activities covered 1968-2002 , and late-life disability was measured in @number@
Trajectory groups were compared on consensus diagnoses of dementia and structural MRI measures of hippocampal volume and entorhinal cortical thickness.
Trajectory of motor FIM scores is moderated slightly by age at the time of injury.
Trajectory-types of HSC were described through k-means cluster analysis.
Tranilast could also inhibit the hypotonicity-induced increase in caspase @number@ activity.
Tranquility of the surroundings , visibility of the face and lucid speech are essential aspects.
Transactive response DNA binding protein @number@ ( TDP-43 ) proteinopathy is the major hallmark of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Transarterial embolization ( TAE ) was performed to control the intractable hemorrhage.
Transcatheter aortic valve implantation is a developing technology that offers an alternative treatment modality for these very high risk patients.
Transcatheter aortic valve implantation ( TAVI ) is an alternative for surgical aortic valve replacement ( AVR ) for high-risk patients.
Transcatheter aortic valve replacement ( TAVR ) is an innovative , high-tech , less invasive alternative.
Transcatheter mitral valve repair has emerged as a feasible and safe alternative in patients with contraindications for surgery or high operative risk.
Transcatheter therapies for structural heart disease represent an alternative therapeutic approach for these patients.
Transcatheter valve implantation could represent an effective solution.
Transcellular propagation of tau aggregates may underlie the progression of pathology in Alzheimer's disease ( AD ) and other tauopathies.
Transconjugants lacked the resistance to aztreonam , ciprofloxacin , gentamicin , tetracycline , and trimethoprim / sulfamethoxazole when compared with the corresponding clinical isolates.
Transcranial direct current stimulation ( tDCS ) modulates human behavior , neuronal patterns , and metabolite concentrations , with exciting potential for neurorehabilitation.
Transcranial Doppler ultrasonography was used to measure left and right middle cerebral artery cerebral blood flow velocity ( CBFV ) .
Transcranial magnetic stimulation and functional imaging showed connectivity between the ipsilateral hemisphere and the paralyzed arm.
Transcranial magnetic stimulation and functional imaging showed connectivity between the ipsilateral hemisphere and the paralyzed arm.
Transcranial magnetic stimulation ( TMS ) assessed motor evoked potentials ( MEPs ) and short interval intracortical inhibition ( SICI ) .
Transcranial magnetic stimulation ( TMS ) is a noninvasive method of cortical stimulation that can map representation of corticospinal output devoted to a muscle.
Transcranial magnetic stimulation ( TMS ) studies have demonstrated that cortical excitability is enhanced in AD patients.
Transcribed interviews were analyzed per established descriptive qualitative techniques.
Transcriptional activity was detected using a luciferase reporter assay.
Transcriptional and genetic association studies of different tissues have revealed common and unique pathways involved in human ageing.
Transcriptionally relevant genetic determinants were addressed by means of single-nucleotide polymorphisms ( SNPs ) proximal to the OA-responsive transcriptionally active CpG.
Transcriptional profiling also showed that BER repair capacity vary during the lifespan in Tg-ArcSwe and wt mice.
Transcriptional programs coupling synaptic activity to changes in gene expression are critical to the plasticity mechanisms underlying higher brain functions.
Transcriptional regulation is a fundamental process in biological systems.
Transcriptional silencing of mitochondrial transcription factor A , TFAM , decreased mtDNA levels by @percent@ in MIN6 cells.
Transcription factor NRF2 , encoded by NFE2L2 , is the master regulator of defense against stress in mammalian cells.
Transcription factors regulate various developmental and functional aspects of B cells.
Transcription intermediary factor 1γ ( TIF1γ ) was suggested to play a role in erythropoiesis.
Transcriptions were coded and analyzed using a template analysis approach.
Transcript levels of most isoforms increased with AD progression.
Transcriptomal analyses showed that Sch9 regulates most genes solely under hypoxia and in the presence of elevated CO ( @number@ ) .
Transcriptome analysis of FACS-purified choroid plexus epithelial cells also predicts their cell-type-specific secretome.
Transcriptome analysis of human brain provides fundamental insight into development and disease , but it largely relies on existing annotation.
Transcriptome analysis of single acinar cells revealed the existence of a minor population of cells expressing progenitor markers.
Transcriptome analysis of the PSHG effect performed in fibroblast cell culture showed that PSHG stimulates processes of tissue development and remodeling.
Transcriptome analysis was done by RNA sequencing.
Transcriptome comparisons of SOX9 + cells with GLT1 + cells showed that the two populations of cells exhibit largely overlapping gene expression.
Transcript profiles associated with the energy metabolism including mitochondrial functions were identified to fluctuate during aging.
Transcripts for these three genes-all players within the spindle assembly checkpoint surveillance mechanism for preventing aneuploidy-were reduced in the same oocyte from an older patient.
Transcripts involved in inflammation and oxidative stress were more abundant.
Transcripts of focus group meetings were coded into themes by two reviewers using NVivo qualitative software.
Transcripts of interviews were analyzed using a coding format with two areas of emphasis.
Transcripts of sessions were analyzed according to grounded theory.
Transcripts of the focus groups were analysed using thematic analysis.
Transcripts of the interviews were analyzed using inductive analysis.
Transcripts were analysed using a thematic analysis broadly informed by the procedures of Grounded Theory.
Transcripts were analysed using inductive thematic analysis.
Transcripts were analyzed by two independent coders to identify major themes.
Transcripts were analyzed thematically.
Transcripts were analyzed using qualitative content analysis within each stratum and later with a comparison between the strata.
Transcripts were coded line-by-line with initial thematic analysis completed by the primary author.
Transcripts were coded using open , axial , and selective coding.
Transduced proteins showed protective effects in a UV-induced skin damage model as well as against skin wrinkles.
Transepidermal water loss and conductivity were measured to assess water-handling properties of the SC.
Transepidermal water loss decreased significantly throughout ( p < @number@ ) , and stratum corneum hydration increased.
Transepidermal water loss decreases with age , which was formerly interpreted as an indication of a decreased sensitivity.
Transepidermal water loss ( TEWL ) and skin color were measured on both sides.
Transepidermal water loss ( TEWL ) , stratum corneum hydration , and skin pH were measured to assess skin barrier function.
Trans-ethnic meta-analyses further improved fine mapping of putative causal variants in loci shared between the African and European ancestry populations.
Trans-fatty acids ( TFAs ) enter the diet through industrial processes and can cause adverse human health effects.
Transfecting MIA PaCa-2 cells with wild-type nestin or with nestin mutated at Thr315 increased migration and invasion.
Transfection of an NEP cDNA expression vector into COS-1 cells elicited the expression of HSF elastase and NEP activities in the transfected cells.
Transfection of GalNAc-T6 significantly reduced both Aβ1-40 and Aβ1-42 generation , but GalNAc-T1 and GalNAc-T4 only reduced Aβ1-40 generation.
Transfection of SH-SY5Y cells or primary rat neurons with full-length PLXNA4 ( TS1 ) increased tau phosphorylation with stimulated by SEMA3A.
Transfection of sirtuin @number@ over-expression plasmid or siRNA increased or decreased sirtuin @number@ expression.
Transfection of sKL , but not mKL , produced detectable Klotho protein in cell culture media.
Transfection of SVBP enhanced VASH1 secretion , whereas knockdown of endogenous SVBP markedly reduced VASH1 secretion.
Transfer effects were found in memory and everyday problem-solving tasks and on memory beliefs.
Transfer function analysis was used to assess baroreflex sensitivity and dynamic cerebral autoregulation.
Transfer function method was used to estimate cerebrovascular impedance.
Transfer maintenance gains were found at follow-up , but only for fluid intelligence and processing speed tasks.
Transfer patients ' median delay from admission to operation was @number@ hours , whereas nontransfer patients waited @number@ hours ( p < @number@ ) .
Transfersomes were prepared by thin film hydration technique , using soy phosphatidylcholine and sodium cholate , combined with high-pressure homogenization.
Transformational paths were found that emerged and terminated at haphazard points in the space.
Transformation was measured using traditional X-ray diffraction and low-angle X-ray diffraction.
Transforming growth factor beta ( TGFβ ) signaling in breast cancer is selectively associated with pulmonary metastasis.
Transforming growth factor-β1-induced phosphorylation of Smad2 and Smad3 was markedly decreased in VASH2 knockdown cells while the expression of Smad2 and Smad3 was unchanged.
Transforming growth factor β ( TGF-β ) and related ligands have potent effects on an enormous diversity of biological functions in all animals examined.
Transforming growth factor-β ( TGFβ ) is a pleiotropic cytokine that is important in the regulation of joint homeostasis and disease.
Transfusion of aged pRBCs or microparticles isolated from aged blood into mice caused lung inflammation.
Transgene excision via Cre-recombinase reverses cognitive decline , even at 18-months of age.
Transgenerational telomere erosion is therefore the material basis of aging at the species level.
Transgenic expression of catalase in mitochondria using a transgenic strategy extends life span and prevents aging-related pathology in mice.
Transgenic mice carrying inactive APH ( mt-APH ) did not develop cataract.
Transgenic mice developed age-dependent lesions leading to severe , yet focal attenuation of epithelium , and a discontinuous basal lamina.
Transgenic mice expressing CPE-QQ did not show any difference in the processing enzyme activity of CPE compared with wild-type mice.
Transgenic mice expressing high levels of neuronal UBB ( @number@ ) exhibit moderately decreased proteasome activity and spatial reference memory deficits at 9months of age.
Transgenic mice overexpressing human preproET-1 selectively in the endothelium ( eET-1 ) exhibit vascular injury in the absence of blood pressure elevation.
Transgenic mice overexpressing mutant human TDP-43 ( herein referred to as hTDP-43 ) are characterized by neurodegeneration and reduced life span.
Transgenic mouse models are powerful tools in exploring the mechanisms of AD.
Transgenic mouse studies showed that endothelial nitric oxide synthase and telomerase reverse transcriptase synergize to confer endothelial stress resistance after physical activity.
Transgenic pigs and plants show promise with high content of n-3 PUFA and low ratio of n-6 / n-3 fatty acids in their tissues.
Transgenic ( Tg ) mouse models of Alzheimer's disease have served as valuable tools for investigating pathogenic mechanisms related to Aβ accumulation.
Transient epileptic amnesia ( TEA ) is a subtype of medial temporal lobe epilepsy with late onset.
Transient evoked otoacoustic emissions ( TEOAEs ) are usually evoked with air conduction ( AC ) stimuli.
Transient ischemic attack ( TIA ) is a neurologic deficit resulting from focal ischemia in the brain , spinal cord , or retina.
Transiently expressed IF5 / BTG4 induced alkaline phosphatase activity in human embryonic kidney ( HEK293T ) and 2T3 cells.
Transient neurological disturbances in migraine aura can mimic other serious conditions and can be easily misdiagnosed.
Transient receptor potential ( TRP ) channels are cationic channels that can act as cellular sensors for mechanical stimuli.
Transient receptor potential ( TRP ) channels have been increasingly implicated in the pathological mechanisms of CNS disorders.
Transient SIRT1 overexpression or chemical induction by resveratrol treatment reverses senescence phenotype , and rescues in vitro PT-ECFC angiogenic defect in a SIRT1-dependent manner.
Transient transfection studies also showed that curcumin increased ATF6-Luc activity , while decreasing the activities of CREBH-Luc and SMILE-Luc.
Transient WT / W42Q binding may catalyze this oxidative misfolding event in the mutant.
Transition analysis was applied to elucidate the transition ages between the morphological states of each component.
Transition analysis was run specific to each method ( which differ by sample selection ) .
Transitioning from standing to walking requires equilibrium to be maintained while a forward propulsive force is generated.
Transitioning to adulthood is not without challenges.
Transition intensity from state of slight deterioration to cognitive stability was @number@ times that of transition to severe deterioration.
Transition probabilities , costs , and utilities were obtained from the AMPLIFY trial and other literature.
Transition probabilities were derived mainly from two French cohorts , CIRVIR and CHANGH.
Transitions to worse function were significantly increased for the same factors ( all P < 0.05 ) .
Transition to an unhealthy state is characterised by multiple biological changes that are not fully explained by lifestyle risk factors.
Translational approaches in clinical and basic science are necessary to provide new therapeutic options for relevant ophthalmological diseases in the future.
Translational biogerontology will require incorporation of both therapeutic and pharmacological concepts.
Translational research for neurodegenerative disease depends intimately upon animal models.
Translational research is needed to leverage discoveries from the frontiers of genome science to improve public health.
Translational research programs offer incredible opportunities to bring cutting edge science into clinical practice.
Translation from mouse to human will entail challenges , among them the multifactorial heterogeneity of human aging.
Translation is controlled by a complex set of mechanisms acting at multiple levels , ranging from global protein synthesis to individual mRNAs.
Translation of preclinical treatments for ischaemia-reperfusion injury into clinical therapies has been limited by a number of factors.
Translation of the knowledge gained from CR research in animal models to disease prevention strategies in humans should provide therapeutic approaches for these diseases.
Translesion synthesis ( TLS ) past DpC was @percent@ compared to that of the unmodified control.
Translocated microbial products then pass through the liver , contributing to hepatic damage , impaired microbial clearance , and impaired protein synthesis.
Translocated SET to the cytoplasm can induce tau hyperphosphorylation.
Translocation of Nrf2 to the nucleus preceded HO-1 protein induction by two compounds.
Translocation of p53 is regulated by androgen-dependent sumoylation mediated by the G3BP2-interacting SUMO-E3 ligase , RanBP2.
Translucency influences the masking ability , color blending effect , and the degree of light curing through these materials.
Translucency is the relative amount of light transmission or diffuse reflection from a substrate surface through a turbid medium.
Translucency of human enamel and dentine increases in direct proportion to the wavelength of incident light in the visible light range.
Transmissibility of vibration to various skeletal landmarks was assessed with a high speed motion analysis system.
Transmission electron microscope examinations revealed skin ultrastructural changes at the dermal epidermal junction ( DEJ ) after @percent@ C-xyloside application for @number@ months.
Transmission electron microscopy revealed that GSPE induced profound dose- and time-dependent alterations in the morphology of PHFs with partial disintegration of filaments.
Transmission of dengue virus ( DENV ) from mosquito to human is dependent upon the survival of the mosquito beyond the virus extrinsic incubation period.
Transmission of pathogens between spatially separated hosts , i.e. , indirect transmission , is a commonly encountered phenomenon important for epidemic pathogen spread.
Transmission of unexpressed mtDNA in the female germline is considered as a reason for the existence of separate sexes , i.e. male and female.
Transmitral inflow , pulmonary vein flow , and pulsed-wave Doppler tissue imaging parameters were measured as expressions of left ventricular diastolic function.
Transmittance varied in the sequence : DEPT≈DABE < DABE≈DMPT≈CEMA < DMPT≈CEMA≈DMAEMA , being more evident at the wavelength of 400nm.
Transolecranon approach was chosen in @percent@.
Transplantation of an older liver will be less tolerant of subsequent injury.
Transplantation of human neural stem / progenitor cells ( hNSCs ) as a regenerative cell replacement therapy holds great promise.
Transplanted ASCs were identified in the lumbar spinal cords with an antihuman mitochondria antibody and cell type-specific markers for neurons or astrocytes.
Transplanted cells are able to differentiate into mature photoreceptors expressing various opsins and can functionally integrate into congenitally blind mice.
Transplant investigators should make strong efforts to recruit patients across the total age spectrum.
Transpore tape was applied to the right upper eyelid of each patient ; the left eye was used as a control.
Transportability was the most influential criterion for overall MMD usability.
Transportation policies and programs should account for social determinants and aim to address social disparities in driving mobility among older adults.
Transporter expression was studied in cortical and hippocampal tissue and linked to extracellular glutamate and glutamate reuptake activity as measured using in vivo microdialysis.
Trans-resveratrol , a polyphenol extracted from Vitis vinifera , has different beneficial effects following its administration on the skin.
Transsphenoidal surgery ( TSS ) is the first choice of treatment.
Transthoracic echocardiogram showed the enlargement of the left atrium and aneurysmal area at the apex.
Transthyretin , complement @number@ and matrilin @number@ proteins revealed a trend of increasing western immunoblotting band densities after hyaluronic acid injections.
Transthyretin revealed significant increases in protein band densities in both the high and low molecular weight hyaluronic acid injection groups.
Transthyretin ( TTR ) is one of the major Aβ-binding proteins acting as a neuroprotector in AD.
Transurethral resection of the prostate ( TURP ) is still considered the gold standard surgical treatment for BPH.
Transurethral resection of the prostate ( TURP ) remains the international standard of care for -patients requiring surgical intervention for BPS.
Transvaginal mesh surgeries have not been proven to be cost-effective.
Transverse and anteroposterior diameters were measured at the subglottic level and at the cricoid ring.
Transverse scaling was calculated for each subject using measures from optical biometry.
Transwell HUVEC-macrophage co-culture system was established to evaluate macrophage migration and adhesion ability.
TRAP staining was used to observe osteoclastes in alveolar bone.
Trauma and obesity , the common risk factors of OA , could trigger the local or systemic inflammatory cytokines cascade.
Trauma center and non-trauma center admission was a proxy for triage accuracy.
Trauma-exposed individuals presented an intermediate N-glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects.
Trauma is an increasingly common problem in geriatric patients ; fractures are frequent among the elderly.
Trauma surgeons agreed more with each other about treatment decisions than shoulder surgeons agreed with each other.
Traumatic brain injuries ( TBIs ) are generally recognized to affect episodic memory.
Traumatic brain injury ( TBI ) , either as an isolated injury or in conjunction with other injuries , is an increasingly common event.
Traumatic brain injury ( TBI ) has become a signature wound of the wars in Iraq and Afghanistan.
Traumatic brain injury ( TBI ) is a major health problem worldwide.
Traumatic brain injury ( TBI ) is the leading cause of death and disability in people younger than @number@ in Western countries.
Traumatic brain injury ( TBI ) is the most common form of head injury and is a leading cause of death worldwide.
Traumatic brain injury ( TBI ) manifests with acute and chronic cell death pathways leading to initial impacted injury and subsequent neurodegeneration.
Traumatic brain injury ( TBI ) results in a variable degree of cerebral atrophy that is not always related to cognitive measures across studies.
Trauma to extremities was the most frequent body region of injury ( @percent@ ) .
Trauma type was not associated with TL and did not account for the association of PTSD with TL.
Trauma with complications ( fracture ) and various presenting complaints underlying medical problems accounted for more than @number@ % of ED visits and hospital admissions.
Travelling outside the village daily also increased PA odds.
Travel to teach was also a barrier as @percent@ of respondents drove @number@ miles or less to the dental school.
Treadmill endurance and maximal oxygen uptake ( VO2 max ) were measured.
Treated eyes had relatively greater enophthalmos than untreated eyes.
Treated eyes had significantly greater marginal reflex distance @number@ measurements ( @number@ mm , p = @number@ ) , highest with bimatoprost and moderate PAP.
Treated groups had remarkable improvements in physical performance measures and inflammatory biomarkers , both of which characterize the frailty syndrome.
Treated PSAF had higher PCNA expression , and lower levels of MnSOD , p21 , p16Ink4A , and Rb.
Treated sites included under-chin and under-chin and jowls.
Treated women exhibit signs of accelerated ovarian aging with concomitant follicle pool depletion , which may be the basis of the observed subfertility.
Treating HDL cholesterol as a continuous predictor , we also determined the HR for each 10-mg / dl increment in HDL cholesterol.
Treating hepatitis C and implementing interventions to manage alcohol use disorders may improve survival among prisoners in the Southeast.
Treating hypertension may slow the progressive decline in carotid artery distensibility observed with aging and improve cerebrovascular health.
Treating OABD is challenging due to medical complexity , comorbidity , diminished tolerance to treatment , and a limited evidence base.
Treating patients with dementia can be challenging for clinicians because of the numerous behavioral and psychological symptoms of dementia ( BPSD ) .
Treating the elderly patient with NVAF presents special challenges because of their heightened risk for both stroke and bleeding.
Treating young transgenic Tg2576 mice with a brain-penetrating β-secretase inhibitor reduced brain amyloid-β by about @percent@ and rescued the age-related cognitive decline.
Treatment adherence is crucial to obtain optimal outcomes such as cure or improvement in quality of life.
Treatment adherence was correlated to improvement of symptoms , though not significantly.
Treatment algorithms are also reviewed based on predictors of response and promising novel treatment options.
Treatment algorithms with a goal of limiting inappropriate treatment of asymptomatic bacteriuria have been developed.
Treatment and control rates for coronary artery disease ( CAD ) in Chinese patients are poorer than rates in western countries.
Treatment and covariate relations with latent class membership were examined.
Treatment and prevention of gastric ulcers is not different between young and elderly patients.
Treatment and replacement with oral vitamin B12 can be as effective as parenteral administration even in patients with pernicious anaemia.
Treatment as prevention has the promise to improve clinical outcomes but remains uncertain as a prevention tool to reduce population-level HIV incidence.
Treatment-associated risks in terms of relative risks of adverse events and premature withdrawal rates did not differ noticeably between the two treatment groups.
Treatment can maintain a tighter and suppler skin with improvement of fine lines and wrinkles.
Treatment changes were evaluated and examined statistically for significant differences.
Treatment comprised eprosartan @number@ mg / day with add-on antihypertensive therapy after @number@ month if required.
Treatment decreases NFL , but treated patients retain higher levels than controls , indicating either continued virus-related injury or an aging-like effect of HIV infection.
Treatment depends on the etiology.
Treatment depends on the stage of the disease.
Treatment differences did not account for the relationships between frailty and mortality.
Treatment duration ranged from @number@ to @number@ weeks.
Treatment effect estimates of different marginal subgroups are , however , not independent.
Treatment effectiveness rate ranged from @percent@ to @percent@.
Treatment effects are influenced by non-weight change-dependant shifts in risk factor levels.
Treatment effects were significantly larger in avanafil @number@ and @number@ mg recipients than @number@ mg recipients.
Treatment failure is defined as persistent nocturia despite on medical therapy for BPH.
Treatment failures occurred in 15% : 3 / 39 ( @percent@ ) received surgery ; 3 / 39 ( @percent@ ) died.
Treatment for bipolar disorder in ageing is similar to treatment for young patients.
Treatment for depression was associated with slower HcV loss in women and men.
Treatment for five days with @number@ μM conjugated Pt-nps decreased cytosolic and mitochondrial reactive oxygen species in N2 and LB25 to a similar extent.
Treatment for frailty focuses on multi-domain interventions to target multiple affected functions in order to decrease the adverse outcomes of frailty.
Treatment for hypertension is recommended in the elderly.
Treatment for iron overload might thus be protective in some cases.
Treatment for medulloblastoma during childhood impairs neurocognitive function in survivors.
Treatment for men who simply have low T remains somewhat controversial.
Treatment for @number@ days with ( - ) -epicatechin increases hand grip strength and the ratio of plasma follistatin / myostatin.
Treatment for rejection largely depends on the type of rejection , the presence of hemodynamic compromise , and time after transplantation.
Treatment for these patients should be provided based on the condition of individual patients.
Treatment goals and medication selection for this population may differ from those for younger patients.
Treatment guidelines generally recommend careful assessment and non-pharmacological treatment approaches for behavioural and psychological symptoms of dementia.
Treatment heterogeneity reflects the limitations in current therapies , paucity of evidence-based effectiveness data and lack of clinical guidelines.
Treatment in a stroke unit has been shown to reduce mortality as well as reduce the likelihood of dependency after stroke.
Treatment-induced premature senescence could be an underlying mechanism.
Treatment in secondary care comprised application of topicals available in primary care or alternative preparations with nurse assistance to improve compliance.
Treatment intervention : PEG @number@ ( 10-30 g / day ) or lactulose ( 10-30 g / day ) for six months.
Treatment is directed towards normalization of natremia when possible , together with the avoidance of both hyponatremic encephalopathy as well as the osmotic demyelinization syndrome.
Treatment is standard for acute uncomplicated cystitis and common for asymptomatic bacteriuria , but definite benefits are few.
Treatment is tailored to the goals and needs of each individual patient.
Treatment levels ranged from @number@ mJ to @number@ mJ total energy delivered per laser treatment spot ( @number@ μm spot size ) .
Treatment may be more difficult because of concomitant diseases and the increase in drug-related side effects.
Treatment modalities include analgesia , joint injection with steroids or hyaluronic acid , oral supplements including glucosamine and chondroitin sulfate , as well as physiotherapy.
Treatment modalities include extra cranial , transcranial , or combined craniofacial approaches.
Treatment modalities varied greatly.
Treatment of affected patients largely relies on antimicrobial agents that act by directly targeting microbial replication.
Treatment of AGE and SAC were found to protect neuronal cells when they were independently co-treated with ROS.
Treatment of aged skin with a topical formulation containing folic acid and creatine counteracted this age-dependent decline by exerting sustained effects on collagen metabolism.
Treatment of aortas of old rats with resveratrol or rapamycin inhibited S6K1 activity , oxidative stress , and improved endothelial NO production.
Treatment of both TNF knockout mice and in vivo TNF blockade in aged mice resulted in significant increases in survival and lessened pathology.
Treatment of cancer in this population is complex as the physiologic changes of aging impact treatment decisions , tolerance , and outcomes.
Treatment of cardiovascular risk factors , especially hypertension , may protect brain function and should be included in prevention strategies for MD.
Treatment of cells with MHY218 resulted in growth inhibition and induction of apoptosis in a concentration-dependent manner.
Treatment of chronic lymphocytic leukemia ( CLL ) is currently undergoing profound changes.
Treatment of circadian abnormality in dementia require light therapy and increased daytime activity.
Treatment of complicated grief : a randomized controlled trial.
Treatment of complicated grief : A randomized controlled trial.
Treatment of DBA / 1J mice with rhIL-21R-Fc reduced the clinical and histologic signs of CIA.
Treatment of DED , combined with psychiatric or neurological disorders , is also discussed.
Treatment of elderly patients with de novo untreated mantle cell lymphoma is based on rituximab combined with chemotherapy.
Treatment of healthy patients up to age @number@ years with most antihypertensive medications reduces cardiovascular morbidity and mortality and possibly cognitive and functional decline.
Treatment of Helicobacter pylori infection is beneficial in patients starting therapy with these agents , especially in the presence of ulcer history.
Treatment ofhematological malignancy is mainly chemotherapy and furthermore it is necessary to keep its dose intensity.
Treatment of HLEB-3 cells with 5-Aza-dC upregulated OGG1 expression.
Treatment of human pancreatic cancer cells with recombinant mouse DCPP1 elevated cell growth , motility , invasiveness , and adhesiveness.
Treatment of hypertension can address to other families of drugs than ACE inhibitors ( ACEI ) and beta blockers.
Treatment of keratinocytes with resveratrol transactivated FOXO3 and increased the expression of its target genes including catalase.
Treatment of mitochondria with H₂O₂ results in reversible inhibition of KGDH due to glutathionylation of the cofactor , lipoic acid.
Treatment of MSCs with increasing doses of interferon-γ exerted no immediate influence on their self-renewal capacity.
Treatment of neuronal cells differentiated from AD-iPSCs with an inhibitor of γ-secretase resulted in the down-regulation of p-tau.
Treatment of Nrf2 knocked-down HaCaT cells with MAPK inhibitors significantly suppressed UVA-induced MMP-1 and AP-1 activities.
Treatment of OAB with antimuscarinic agents may result in cognitive decline , especially in patients with Alzheimer's disease ( AD ) .
Treatment of pRBCs with amitriptyline inhibited acid sphingomyelinase activity , ceramide accumulation , and microparticle production during pRBC storage.
Treatment of primary dermal fibroblasts with glycitin increased cell proliferation and migration.
Treatment of SH-SY5Y cells with curcumin ( @date@ μmol / L ) for @number@ h did not significantly affect their viability.
Treatment of SH-SY5Y cells with curcumin ( @date@ μmol / L ) for @number@ h did not significantly affect their viability.
Treatment of sleep problems in dementia also contribute to the better management of dementia.
Treatment of symptomatic UTIs with antibiotics is expensive and can result in the development of antimicrobial resistance.
Treatment of T24 cells with DATS resulted in potent anti-proliferative activity.
Treatment of the chest and dorsal hands yielded significant visual improvement.
Treatment of the dorsal hands produced good overall improvement ( OI ) , with good improvement of protruding veins.
Treatment of the face and neck reduced the mean Fitzpatrick-Goldman Wrinkle Classification score by @number@ and @percent@ , respectively.
Treatment of the peripheral hearing loss often involves hearing aids , whereas auditory and psychologic training seems to be important in central auditory disturbance.
Treatment of type @number@ diabetes in the elderly represents a major challenge both in terms of clinical management and public health.
Treatment of vascular and modifiable behavioral risk factors reduces the risk of stroke and may also reduce the risk of emotional changes after stroke.
Treatment of widespread actinic keratoses ( AKs ) and extensive photodamage is a challenge.
Treatment of WO is based on modifying drug schedule , meal timetable and / or increasing dopamine replacement therapy.
Treatment options are also being identified.
Treatment options are discussed.
Treatment options are limited and the use of texture-modified food and fluids ( TMF ) is a widespread clinical practice.
Treatment options are limited due to the complexity of underlying disease factors.
Treatment options focus on reducing sinonasal inflammation when present , ruling out other treatable causes , and counseling patients on safety measures.
Treatment options for differentiated thyroid cancer include surgery , levothyroxine , radioactive iodine , external beam radiotherapy and kinase inhibitors.
Treatment options for frail , older adults are discussed , including physiologic system-targeted interventions and geriatric models of care.
Treatment options include watchful waiting , life-style modification , pharmacologic treatment , and surgery.
Treatment options in light of new goals and the danger of hypoglycemia will be detailed.
Treatment options should be tailored for elderly patients based on the comprehensive evaluation and the evidence from clinical trials for.
Treatment outcome data for these cases were collected as part of a larger investigation of Peaceful Mind.
Treatment paradigms for cardiovascular disease have also been rapidly evolving ; minimally invasive , catheter-based approaches are increasingly used as first-line therapy.
Treatment patterns for heart failure fall short of society guidelines.
Treatment patterns may thus be suboptimal.
Treatment quality is frequently inadequate in terms of follow-up and monitoring.
Treatment recommendations for mild SCH are controversial , which raises concerns about the natural history of mild SCH.
Treatment- related adverse events were mild and reversible.
Treatment-related AEs occurred with equal incidence ; most were mild to moderate , transient , and related to injection procedure.
Treatment-related chronic conditions develop years after therapy , and this supports the need for lifelong follow-up.
Treatment-related eyelid ptosis followed @number@ of @number@ ( @percent@ ) treatments , all of which resolved spontaneously.
Treatment remains supportive , with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease.
Treatment results improved gradually throughout the treatment program and continued to the two-month follow up.
Treatments are available , but the critical factor is to define individuals at risk from osteoporotic fractures.
Treatments are limited and still inconsistent.
Treatments are still mostly symptomatic.
Treatment satisfaction was self-assessed by questionnaire.
Treatments can often stabilize weight , but weight loss should be used to trigger discussion of goals of care and treatment options.
Treatments consisted of four sessions at 2-4 week intervals.
Treatments for Alzheimer's disease have fallen within the purview of geriatric psychopharmacology.
Treatments for this region range from topical prescriptions to enhance the brow hair to topical cosmeceuticals that improve the tone and texture of the skin.
Treatment should be monitored for benefits and adverse effects.
Treatments of the chest demonstrated significant visual improvement.
Treatment-specific side effects such as bleeding and atrial fibrillation may , at least partly , be related to off-target inhibition of non-BTK kinases.
Treatments that optimize adaptation in patients who present with trapeziometacarpal arthrosis-related symptoms and disability merit additional study.
Treatments that substantially extend lifespan must suppress multiple pathologies that otherwise limit lifespan , but whether they suppress the entire aging process remains undemonstrated.
Treatment strategies in managing supra-patellar bursitis include the aspiration of joint synovial fluid and then followed by steroid injection into the bursa.
Treatment strategies to address these conditions such as weight management and prevention of overweight and obesity are important even in older people.
Treatment studies suggest the importance of accurate delineation of ADHD and BD.
Treatment success of @percent@ or less was considered unacceptable.
Treatment success was an MLFS increase ≥1 point at Week @number@
Treatments were tabulated according to facial region and arbitrarily designated as rhytides , acne scars , lips , infraorbital , nasolabial , and general contour.
Treatments which have been shown to be of significant benefit include angiotensin converting enzyme inhibitors , beta-blockers , aldosterone antagonists and angiotensin receptor blockers.
Treatments with enhanced safety margins and that offer chondroprotective effects are unmet needs.
Treatment toxicity and mortality data were abstracted from the chart.
Treatment was given for at least @number@ months and up to @number@ months.
Treatment was repeated once.
Treatment was safe and tolerable for all subjects.
Treatment was safe and well tolerated , as directly determined in the survey.
Treatment was switched after 8-week washout.
Treatment was well tolerated.
Treatment was well tolerated.
Treatment was well tolerated in all patients , with no unanticipated side effects.
Treatment with betaine inhibited ROS generation and GSSG concentration in colonic mucosa.
Treatment with bimatoprost was generally well tolerated , with conjunctival hyperaemia ( mostly mild ) , growth of eyelashes and ocular pruritus being commonly reported.
Treatment with botulinum toxin ( BTX ) type A has become increasingly important in various clinical areas in dermatology.
Treatment with corticosteroids is optimal.
Treatment with each of @number@ GSK3β inhibitors or small hairpin RNA knockdown of GSK3β abolished fibril formation and prevented cell death.
Treatment with either API-2 or Cdk4-I was also effective in suppressing resistance to cis-platinum ( II ) -diamine-dichloride in the cells with acquired radioresistance.
Treatment with fluoxetine stimulated neurogenesis and prevented the emergence of depression-like behaviors.
Treatment with GDF11 significantly inhibited CSE-induced cellular senescence and upregulation of inflammatory mediators , partly through Smad2 / 3 signalling in vitro.
Treatment with H₂O₂ significantly stimulated the formation of oxygen free radicals.
Treatment with IL-1β or Wnt decreased the level of Col2a1 and increased those of Mmp3 or Mmp13 , whereas Lrp5 knockdown ameliorated these effects.
Treatment with lipid-lowering drugs , statins , is common all over the world.
Treatment with metformin started at the age of @number@ months increased mean life span by @percent@ and maximum life span by @number@ month.
Treatment with mito-TEMPO reduced eIF2α phosphorylation and viral replication , suggesting that mitochondrial ROS act to promote viral replication.
Treatment with platelet inhibitors plays an additional important role in secondary prevention.
Treatment with PPARγ activators or overexpression of PPARγ in hADSCs at passage @number@ could recover @date@ expression levels and increase @date@ promoter activity.
Treatment with RDPs improved OHRQoL , but denture-related problems partly remained , and new problems related to RDPs occurred 1-5 years after treatment.
Treatment with siVASH2 significantly inhibited s.c. tumor growth by abrogating tumor angiogenesis.
Treatment with statins can significantly reduce CVD events and mortality in both primary and secondary prevention.
Treatment with systemic agents should be individualized , with consideration of patient preference , performance status , comorbidities , and projected lifespan.
Treatment with the antioxidant , N-acetyl cysteine ( NAC ) , partially rescued the growth disadvantage of mutant cells in vitro and in vivo.
Treatment with the anti-oxidant N-acetylcysteine reduces ROS elevation and normalizes TGF-β signaling and target gene expression.
Treatment with the exogenous molecular chaperone tauroursodeoxycholic acid ( TUDCA ) ameliorated proteinuria-induced tubulointerstitial lesions and PTC apoptosis in aged mice.
Treatment with the Nogo-66 antagonist promoted myelin repair , improved cognition and memory , and downregulated pro-inflammatory factors.
Treatment with the small molecule NS-0011 , which increases CDK5 accumulation in the nucleus , suppressed both cancer cell proliferation and xenograft tumorigenesis.
TREAT was supported by a post-acute care enablement ( PACE ) team , providing short-term nursing support immediately following discharge.
TREC levels in CD4 + T cells were significantly lower in individuals with a high disability.
TREC levels in peripheral blood T lymphocytes were similar between IBD patients and controls.
Trec was systematically higher than Tint by @number@ °C ( @percent@ CI : @number@ @date@ °C ) .
Tree-based metrics were compared with classical network metrics.
T regulation of PDE5 expression has been accepted as one of the major mechanisms controlling vasodilator mechanisms in penile tissue.
TREM1 is an activating receptor and requires association with transmembrane adapter molecule DAP12 ( DNAX-associated protein @number@ ) for cell signaling.
TREM2 and Iba1 levels were not associated with plaques , tangles , neuropathological criteria , or cognitive performance.
TREM2 encodes a receptor expressed in microglia which is thought to influence neurodegeneration by sensing damage signals and regulating neuroinflammation.
TREM2 has been shown to regulate the phagocytic ability of myeloid cells and their inflammatory response.
TREM2 is a receptor expressed on innate immune cells.
TREM2 p.L211P resides within the cytoplasmic domain and p.W191X is a stop-gain mutation within the shorter TREM- @date@ transcript.
TREM2 was significantly upregulated in sAD frontal cortex but stable in hippocampus.
TREM and TREM-like receptors are a structurally similar protein family encoded by genes clustered on chromosome 6p21.11.
Tremor in spirals was rated ( 0-3 ) by a blinded neurologist , and a spiral score ( range , 0-6 ) was assigned.
Tremor severity was assessed with a clinical rating scale ( total tremor score , range 0-36 ) .
Trend analysis revealed a nonstatistically significant ( P < @number@ ) increase in cases over the period.
Trend analysis showed mortality rates over the entire @number@ years were stable ( average annual percent change of less than one percent ) .
Trend analysis was used to determine the lifespan-developmental pattern of the dream content categories.
Trend data will be obtained.
Trends are estimated by mixed-effects regression models ( MRMs ) with time , age , and time-age interaction predictors.
Trends are much worse when bathing is excluded as an ADLs item.
Trends for general memory , working memory , and spatial ability generally indicated stability , or small increases in heritability in mid-life.
Trends for lower FA were seen in the CT-treated survivors.
Trends for severe pre-eclampsia also showed a modest birth cohort effect , with women born in the 1970s at increased risk.
Trends in alcohol consumption in old age are highly sensitive for cohort effects.
Trends in cancer survival in Germany between 2002-2004 and 2008-2010 were described.
Trends in death rates , prevalence of chronic conditions , risk factors , vaccinations , health care utilization , and expenditures are summarized.
Trends in eyebrow grooming are constantly evolving , often requiring plucking , waxing , or laser hair removal to style.
Trends in fast-food restaurant portion sizes can inform policy decisions.
Trends in fat intake were similar across the BMI categories.
Trends in lifetime smoking prevalence correlated negatively with both rectangularization and longevity extension , but more negatively with rectangularization.
Trends in main findings were considered in five periods.
Trends in notification rates from @number@ onwards were determined with a non-parametric test for trend.
Trends of annual prescription rates were tested using adjusted segmented regression analysis.
Trends would be less favorable had education of older population not increased over time.
Trepanation has been performed by people interested in enhancing mental power and well-being since the early 1960s.
Tretinoin also improved facial hyperpigmentation versus placebo under Wood's lamp ( P = @number@ ) .
TRF1 was significantly reduced , TRF2 showed a slight up-regulation.
TRF2 protects telomere ends and showed elevated expression levels.
TRG trained for @number@ hour twice a week for @number@ weeks.
TRH , TSH and free thyroxine serum levels were measured in blood samples collected every four hours for @number@ hours.
TRIAD3A is an E3 ubiquitin ligase that recognizes and facilitates the ubiquitination of its target for degradation by the ubiquitin-proteasome system ( UPS ) .
Trial characteristics and study objectives were extracted from the registry website.
TRIAL REGISTRATION : ACTRN12608000250336.
TRIAL REGISTRATION : ACTRN12612001253897 , date of registration @date@ , first patient was randomized @date@ .
TRIAL REGISTRATION : ACTRN12615000879561 registered prospectively 21 / 8 / 2015.
TRIAL REGISTRATION : ANZCTR @number@
TRIAL REGISTRATION : Australian and New Zealand Clinical Trial Registration Number : ANZCTR12612000451808.
TRIAL REGISTRATION : Australian New Zealand Clinical Trials Registry : ACTRN12612000087853.
TRIAL REGISTRATION : Australian New Zealand Clinical Trials Registry : ACTRN12613001153707 .
TRIAL REGISTRATION : Chinese Clinical Trial Registry ChiCTR-OOC-16008846.
TRIAL REGISTRATION : Chinese Clinical Trial Registry ( @date@ ) : ChiCTR-TRC-13003264.
TRIAL REGISTRATION : ClinicalsTrials.gov NCT00116194.
TRIAL REGISTRATION : Clinical Trial Registration : NCT01931111 ( Date of trial registration : @date@ ) .
TRIAL REGISTRATION : ClinicalTrials.gov identifier : ChiCTR-TRC-14004727 ; @date@ .
TRIAL REGISTRATION clinicaltrials.gov Identifier : NCT00000620.
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT00119795.
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT00177671.
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT00225849.
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT00259454.
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT00270647.
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT00287586.
TRIAL REGISTRATION : clinicaltrials.gov Identifier NCT00332670.
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT00345176.
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT00378352.
Trial Registration : clinicaltrials.gov Identifier : NCT00799617.
Trial Registration : clinicaltrials.gov Identifier : NCT00799617.
Trial Registration : clinicaltrials.gov Identifier : NCT00799617.
Trial Registration : clinicaltrials.gov Identifier : NCT00799617.
Trial Registration : clinicaltrials.gov Identifier : NCT00847912.
Trial Registration : clinicaltrials.gov Identifier : NCT00990132.
Trial Registration : clinicaltrials.gov Identifier : NCT01045330.
TRIAL REGISTRATION : ClinicalTrials.gov Identifier : NCT01067508.
TRIAL REGISTRATION : clinicaltrials.gov Identifier = NCT01072500.
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT01072500.
TRIAL REGISTRATION : ClinicalTrials.gov identifier NCT01072500 .
TRIAL REGISTRATION : Clinical Trials.gov Identifier : NCT01083082.
TRIAL REGISTRATION : clinicaltrials.gov identifier : NCT01142349.
Trial Registration : clinicaltrials.gov Identifier : NCT01269697.
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT01307865.
Trial Registration : clinicaltrials.gov Identifier : NCT01408901.
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT01415934.
TRIAL REGISTRATION : ClinicalTrials.gov identifier : NCT01420640 , registered @date@ .
Trial Registration : clinicaltrials.gov Identifier : NCT01426880.
Trial Registration : clinicaltrials.gov Identifier : NCT01565642.
TRIAL REGISTRATION clinicaltrials.gov Identifier : NCT01732809.
TRIAL REGISTRATION : ClinicalTrials.gov Identifier NCT01763203 .
Trial Registration : clinicaltrials.gov Identifier : NCT01908972.
TRIAL REGISTRATION : ClinicalTrials.gov Identifier : NCT01960907 @date@ ( retrospectively registered ) Clinical tRials fOr elderly patients with MultiplE Disease ( CHROMED ) .
TRIAL REGISTRATION : clinicaltrials.gov Identifier : NCT01979302.
TRIAL REGISTRATION : ( ClinicalTrials.gov Identifier : NCT02017847 , registered @number@
TRIAL REGISTRATION : ClinicalTrials.gov , Identifier : NCT02158741 .
TRIAL REGISTRATION : Clinicaltrials.gov identifier : NCT02261961 , registration date @date@ , recruitment active.
TRIAL REGISTRATION : Clinicaltrials.gov Identifier : NCT02295527 .
TRIAL REGISTRATION : Clinicaltrials.gov identifier : NCT02392013 .
TRIAL REGISTRATION : ClinicalTrials.gov Identifier : NCT02428387.
TRIAL REGISTRATION : ClinicalTrials.gov Identifier : NCT02626377 .
( Trial registration : ClinicalTrials.gov Identifier : NCT02736760 ) .
TRIAL REGISTRATION : ClinicalTrials.gov Identifier : NCT02736760 .
TRIAL REGISTRATION : ClinicalTrials.gov ID : NCT02800291 , retrospectively registered @date@ .
TRIAL REGISTRATION : Clinicaltrials.gov NCT00605072.
TRIAL REGISTRATION : ClinicalTrials.gov NCT00742547.
TRIAL REGISTRATION : ClinicalTrials.gov , NCT01283659.
TRIAL REGISTRATION : ClinicalTrials.gov NCT01323335.
TRIAL REGISTRATION : ClinicalTrials.gov NCT01325103 - Registered @date@ .
TRIAL REGISTRATION : ClinicalTrials.gov NCT01340365.
TRIAL REGISTRATION : Clinicaltrials.gov : NCT01362686 ( @url@
TRIAL REGISTRATION : ClinicalTrials.gov NCT01371214.
TRIAL REGISTRATION : ClinicalTrials.gov NCT01530724.
TRIAL REGISTRATION : ClinicalTrials.gov NCT01559324.
TRIAL REGISTRATION : ClinicalTrials.gov NCT01569685 .
TRIAL REGISTRATION : Clinicaltrials.gov NCT01660126 ; registered @date@ .
TRIAL REGISTRATION : ClinicalTrials.gov NCT01661894.
TRIAL REGISTRATION : Clinicaltrials.gov NCT01786941.
TRIAL REGISTRATION : ClinicalTrials.gov NCT01952366.
TRIAL REGISTRATION : Clinicaltrials.gov NCT02045004 .
TRIAL REGISTRATION : ClinicalTrials.gov NCT02172612 .
TRIAL REGISTRATION : ClinicalTrials.gov : NCT02183740 , registered @date@ .
TRIAL REGISTRATION : ClinicalTrials.gov , NCT02250365 .
TRIAL REGISTRATION : ClinicalTrials.gov , NCT02308228 .
TRIAL REGISTRATION : ClinicalTrials.gov , NCT02379455 .
TRIAL REGISTRATION : ClinicalTrials.gov , NCT02524327 .
TRIAL REGISTRATION : Clinicaltrials.gov : NCT02588664 ; @date@ .
TRIAL REGISTRATION : ClinicalTrials.gov , NCT02629666 .
TRIAL REGISTRATION : ClinicalTrials.gov , NCT02829762 .
Trial Registration : clinicaltrials.gov : NCT03020381.
TRIAL REGISTRATION : ClinicalTrials.gov : NCT03073772 .
TRIAL REGISTRATION : ClinicalTrials.gov Protocol Registration System : NCT01029171 ; registered @date@ .
TRIAL REGISTRATION : CLINICAL TRIALS REGISTRATION : NCT01944124.
TRIAL REGISTRATION : CLINICAL TRIALS REGISTRATION NUMBER : NCT01013220.
TRIAL REGISTRATION : Current Controlled Trials ISRCTN30080637.
TRIAL REGISTRATION : Current Controlled Trials ISRCTN67209155.
TRIAL REGISTRATION : Current Controlled Trials ISRCTN80470273 .
TRIAL REGISTRATION : Current Controlled Trials ISRCTN96090441.
TRIAL REGISTRATION : Current Controlled Trials ISRCTN96090441 ( retrospectively registered ) .
TRIAL REGISTRATION : Dutch Trial Register NTR-2051 www.trialregister.nl / trialreg / admin / rctview.asp ? TC = 2051.
TRIAL REGISTRATION : Dutch Trial Register under number NTR2751.
TRIAL REGISTRATION : Dutch Trial Registry : NTR @number@ @url@ ( Archived by WebCite at @url@
TRIAL REGISTRATION : EU Clinical Trials Register ( EU-CTR ) ; EudraCT number 2009-011742-26 ; / ctr-search / trial / 2009-011742-26 / AT.
TRIAL REGISTRATION : International Standard Registered Clinical Study Number ( ISRCTN ) : @number@ @url@ ( Archived by WebCite at @url@
TRIAL REGISTRATION : ISRCTN01187372 .
TRIAL REGISTRATION : ISRCTN11972147.
TRIAL REGISTRATION : ISRCTN22749696.
Trial Registration : ISRCTN67209155.
Trial Registration : isrctn.org : ISRCTN35739639.
TRIAL REGISTRATION : ISRCTN register ; @url@
TRIAL REGISTRATION : ISRCTN registry , ISRCTN16076575 .
TRIAL REGISTRATION : NCT00561145.
TRIAL REGISTRATION : NCT01052636.
TRIAL REGISTRATION : NCT01080196 ; @date@ ( retrospectively registered ) .
TRIAL REGISTRATION : NCT01957319 , First received : @date@ .
TRIAL REGISTRATION : NCT02191969.
TRIAL REGISTRATION : NCT02413385 ( Clinicaltrials.gov ) .
TRIAL REGISTRATION : NCT02857127 .
TRIAL REGISTRATION : Netherlands Trial Register , identifier : NTR3842 .
TRIAL REGISTRATION : Netherlands Trial Register ( NTR ) identifier : NTR2843.
TRIAL REGISTRATION : Not applicable.
TRIAL REGISTRATION NUMBER : ClincialTrials.gov number , NCT00626288.
TRIAL REGISTRATION NUMBER : ClinicalTrial.gov : NCT01724996.
TRIAL REGISTRATION NUMBER : Clinicaltrials.gov NCT01666340.
TRIAL REGISTRATION NUMBER : [ ClinicalTrials.gov : NCT02802371 ] Registered in @date@ .
TRIAL REGISTRATION NUMBER : CRD42014009800.
TRIAL REGISTRATION NUMBER : CRD42016039650.
Trial registration number ( EudraCT ) : 2006-001917-14.
Trial registration number ISRCTN25539102.
TRIAL REGISTRATION NUMBER : NCT01134406.
TRIAL REGISTRATION NUMBER : NCT01138111.
TRIAL REGISTRATION NUMBER : NCT01672177.
TRIAL REGISTRATION NUMBER : NCT02123641.
TRIAL REGISTRATION NUMBER : NCT02544360 , Pre-results.
TRIAL REGISTRATION NUMBER : Not applicable.
TRIAL REGISTRATION NUMBER : Not applicable.
TRIAL REGISTRATION NUMBER : Not applicable.
TRIAL REGISTRATION NUMBER : NTR no.
TRIAL REGISTRATION NUMBER : The biobank connected to FAC Clinic is approved by the Scientific Ethical Committee ( H-1-2011-081 ) .
TRIAL REGISTRATION : Prospero CRD42011001349.
TRIAL REGISTRATION : PROSPERO registration number : CRD42015025066.
TRIAL REGISTRATION : PROSPERO Registration : PROSPERO 2016 : CRD42016033846 ; @url@ display record.asp ? ID = CRD42016033846 ( Archived by WebCite at @url@
TRIAL REGISTRATION : Registered NO. the University Hospital Medical Information Network in Japan ( UMIN000014446 ) .
TRIAL REGISTRATION : Registration trial number : DRKS00009726 on DRKS , registered @date@ , retrorespectively registered.
TRIAL REGISTRATION : Retrospectively registered ClinicalTrials.gov Identifier : NCT02800304 , @date@ .
TRIAL REGISTRATION : SAMMPRIS ClinicalTrial.gov number , NCT01492296.
TRIAL REGISTRATION : The current study was registered at the Dutch Trial Register ( NTR2297 ; @date@ ) .
TRIAL REGISTRATION : The Effect of Taurine on Morbidity and Mortality in the Elderly Hip Fracture Patient.
TRIAL REGISTRATION : The Netherlands National Trial Register : NTR3527.
TRIAL REGISTRATION : The present study was registered under International Standard Randomized Controlled Trial Number registry : ISRCTN53778569.
TRIAL REGISTRATION : The protocol has been registered ( NCT01785537 ) and approved by the Ethics Committee of the University of Chieti ( Record n.
TRIAL REGISTRATION : The randomized trial component of this study was registered at ClinicalTrials.gov ( NCT01340365 ) .
TRIAL REGISTRATION : The study was registered in ISRCTN71142240 in @date@ , retrospectively registered.
TRIAL REGISTRATION : The study was registered with ClinicalTrials.gov ( NCT01685684 ) .
TRIAL REGISTRATION : The trial is registered with the Dutch Trial Register under number NTR2270 .
TRIAL REGISTRATION : The trial was registered at ClinicalTrials.gov @date@ , identifier : NCT01841853.
TRIAL REGISTRATION : The trial was registered in ClinicalTrials.gov @date@ , identifier : NCT02043262.
TRIAL REGISTRATION : The trial was registered on @date@ at ClinicalTirals.gov ( ID number NCT01571427 ) .
TRIAL REGISTRATION : This Study was registered at www.clinicaltrials.gov with number NCT00848406 on @date@ .
TRIAL REGISTRATION : This trial has been registered at the U.S. National Institutes of Health under ClinicalTrials.gov : NCT01045746.
TRIAL REGISTRATION : This trial is registered in the Dutch Trial Register under number NTR1823.
TRIAL REGISTRATION : This trial ( NCT02999581 ) was retrospectively registered on @date@ .
TRIAL REGISTRATION : This trial was registered with ClinicalTrials.gov ( registration number : NCT02077153 ) on @date@ .
TRIAL REGISTRATION : This trial was retrospectively registered.
TRIAL REGISTRATION : trialregister.nl Identifier : NTR2829.
TRIAL REGISTRATION : UMIN-CTR clinical Trial : UMIN000010439.
TRIAL REGISTRATION : UMIN-CTR No.
Trials comparing composite and ceramic onlays are needed.
Trials examining low protein diet to minimize accumulation of urea and other toxins suggest a clinical benefit in terms of slowing progression of CKD.
Trials missing all four components were rare ( @percent@ ) and were observed in both younger and older adults.
Trials of acetylcholinesterase inhibitors , used for the treatment of clinical symptoms of Alzheimer's disease , have generally focused on overall cognitive effects.
Trials of antidepressants should generally be reserved for individuals with depression where the symptoms are distressing and surpass the threshold for major depression.
Trials of oral DHEA should be undertaken to examin their potential for preventing tears in fragile aging skin.
TRIALS REGISTRATION : Australian & New Zealand Clinical Trials Registry : ACTRN12613000234718.
Trials related to this study were registered at clinicaltrials.gov as NCT00005121 ( Framingham Offspring Study ) and NCT00005487 ( Multi-Ethnic Study of Atherosclerosis ) .
Trials should follow Fédération dentaire internationale recommendations and enhance their methodology.
Trials showed that assisted hatching may increase the chance of pregnancy in women with poor history.
Trials testing additional doses of vitamin D in different segments of the population are needed.
Trials that are specifically designed for older patients do not often incorporate a geriatric assessment in their design.
Trials that examined the effect of vitamin C supplements on cancer risk are few.
Trials were repeated for three stair riser height conditions ( @number@ mm , @number@ mm , and @number@ mm ) .
Trial-to-trial reaction time ( RT ) variability is consistently higher in children and older adults than in younger adults.
TRIAP1 / PRELI complexes exert lipid transfer activity in vitro and supply phosphatidic acid ( PA ) for CL synthesis in the inner membrane.
Tricep skinfold thickness was measured using a skinfold calliper.
Trichlorfon and acephate are two organophosphorus compounds ( OPs ) used worldwide as insecticide and which cause serious effects to non-target species.
Trichlorfon and mipafox presented the lowest percentage of reactivation of inhibited NTE and the lowest ratio IC50 NTE / IC50 AChE.
Trichothiodystrophy ( TTD ) is an autosomal recessive disorder with symptoms affecting several tissues and organs.
Trichrome-stained slides were de-identified and assessed by a liver pathologist blinded to donor age.
Trigeminal nerve root entry zone is located inside pioarachnoidal infundibulum subpial cavity.
Triggering receptor expressed on myeloid cells ( TREMs ) receptors constitute a family modulators in human innate immunity system that encode by a gene cluster.
Triggers exacerbating asthma are similar for all ages , but inhaled viruses and drug interactions have greater clinical significance in the elderly.
Triglyceride levels ( decrease OR per unit = @number@ p = @number@ ) , but not LDL particle size , were associated with female longevity.
TRIIFL aims to demonstrate that : @number@
TRIM25 co-precipitated with p53 and Mdm2 and interfered with the association of p300 and Mdm2 , a critical step for p53 polyubiquitination.
TRIM25 increased p53 and Mdm2 abundance by inhibiting their ubiquitination and degradation in @number@ S proteasomes.
TRIM was significantly associated with correction of medication discrepancies but had no effect on number of medications or reduction in PIMs.
Trinita Hospital , Cagliari , and \ "Monsignor Angioni \ " Nursing Home , Quartu Sant'Elena ( Cagliari , Italy ) .
Triolein treatment reduced the IL-6 expression and ROS generation in keratinocytes and this effect was reflected in downregulation of MMP1 expression in fibroblasts.
Triosephosphate isomerase ( TIM ) is a ubiquitous enzyme , which appeared early in evolution.
Triple logistic modeling of longitudinal data was performed to determine patterns of peripubertal and pubertal growth.
Triple therapy confers a higher bleeding risk than either warfarin or dual antiplatelet therapy alone.
Triplicate photographs were provided in identical image sets to @number@ community dermatologists for blinded rating using the dermatologic assessment scoring scale.
Trisomy @number@ ( T21 ) , Down Syndrome ( DS ) is the most common genetic cause of dementia and intellectual disability.
TrkA was shown to interact with AβPP and suppress AβPP-mediated transcriptional activation.
TRM measurement was performed by qPCR and was normalized to the single copy 36B4 gene relative to a reference DNA sample ( K562 ) .
TRM was measured in buccal-derived DNA samples from individuals for whom previous TRM data from blood samples existed.
TROM was reduced on the dominant side compared with the nondominant side in young elite badminton players , irrespective of gender.
Trophic factor receptor occupancy was calculated to evaluate differences in trophic factor concentrations.
Trophic factor receptor occupancy was calculated to evaluate the potential biological effectiveness of the differences in trophic factor concentrations.
Trospium chloride XR was as effective in subjects with OAB taking seven or more concomitant medications as in the overall pooled study population.
Trough serum risperidone and 9-hydroxyrisperidone concentrations were measured.
TRT improved depressive symptoms as well as health-related quality of life.
TRT is commonly prescribed in Korea , despite the paucity of studies on the effects of TRT in Asian populations.
TRT is currently prescribed for older men with either low serum testosterone ( T ) or low T plus accompanying symptoms of hypogonadism.
TRT should , in theory , approximate natural endogenous production of the hormone.
True / False ? ) .
Truncal lean mass was significantly higher in the protein group at @number@ months ( P = @number@ ) .
Truncated tau expression also enhanced Aβ-induced mitochondrial potential loss in primary neurons.
Truncation and mutagenesis studies revealed residues at both the amino and carboxyl termini of SIRT7 that are involved in RNA-binding and important for activity.
Truncations can be cataractogenic.
Truncation studies of peptide 1a revealed the significance of the peptide sequence length.
Trunk acceleration was measured during a 5-min treadmill session using a 3D accelerometer.
Trunk angles during both transfers were the most different parameters between the groups.
Trunk fat and fear of falling changed differently among the two groups.
Trunk muscle characteristics may be altered with aging and / or chronic LBP.
Trunk pitch , trunk-pitch velocity , and gait speed increased with GVS , whereas trunk-pitch velocity and gait speed decreased in narrow-base walking.
Trunk roll significantly decreased only in OA with GVS in WT.
TRUS may reveal prostate volume reduction ( suggestive of hypogonadism ) or enlargement , which can be related to aging or even metabolic abnormalities.
Trust correlated with life expectancy ( r = @number@ ) and mortality ( r = @number@ ) and partly mediated their relations to income inequality.
TRX80 also promotes the differentiation of mouse peritoneal and human macrophages toward a proinflammatory M1 phenotype.
Trying to reach such perspective , we are guided by paths of the integrative approach ( inter , multi and transdisciplinary ) and intersectoral.
Trypsin digestion and transmission electron microscopy also were performed.
Tryptase mast cells and extracellular tryptase were often associated with areas of early and more advanced stages of calcification.
Tryptase mast cells were found in all stages of pineal gland development independently of the presence of local tissue lesions.
Tryptic digestion of a truncated form of filensin suggested that the binding site for α-crystallin may be in the N-terminal region.
TSA is a fermentation product of Streptomyces originally used as an antifungal agent.
T-scores and FRAX scores likely underrepresent a diabetic patients risk for fracture , and this should be taken into consideration in treatment decisions.
T.S. Eliot once proposed that there were two sorts of problems in life.
TSFI provides a practical and accurate assessment tool for identifying elderly trauma patients who are at increased risk of both short-term and long-term outcomes.
TSH assay is the best parameter of the thyroid function.
TSH at baseline was not significantly associated with incident AF in euthyroid participants or those with subclinical hypothyroidism.
TSH trends positively and RAIU at @number@ hours correlates negatively with aging of the pituitary axis.
TSP-1 knockout animals had significantly less arterial stiffening in response to d-flow than wild-type carotid arteries.
TSPO drug ligands have been proposed as therapeutic agents to regulate steroid levels in the brain and testis.
TSPO expression can be quantified in-vivo using the positron emission tomography ( PET ) radioligand [ ( @number@ ) F ] -FEPPA.
TSPO is a drug- and cholesterol-binding protein found at particularly high levels in steroid synthesizing cells.
TS provided supportive therapeutic strategies.
TSPs are also critically important in the development and ultimate outcome of the complications associated with atherosclerosis myocardial infarction , and heart hypertrophy and failure.
TT and SHBG were significantly lower in men with MetS than in men without MetS.
T / T carriers died @number@.8-3 years later than the C / C carriers.
TT concentrations were significantly lower in men with baseline and incident hypertension.
TT could be considered to be a useful tool in BPH treatment.
TT decreased fat mass ( total , central , extremity , and SAT ) and increased BioT and LBM versus placebo.
TTD no longer determines homecare expenditures when disability is controlled for.
TT , E ( @number@ ) , E ( @number@ ) / testosterone and SHBG were negatively correlated with blood glucose.
T test for independent samples confirmed lower obsessive-compulsive craving in older patients.
T-tests and repeated measures ANOVA were used to examine depression and self-assessed wisdom outcomes using measures previously tested with older adults.
T Tests were used to assess differences between equol and nonequol producers.
T tests were used to compare groups at baseline.
TT may be associated with increased inflammatory activity.
TT performance outcomes were converted to mean percentage changes in power output.
TTR-RBPs are emerging as key regulators of a wide variety of genes influencing kidney physiology and pathology.
TT was diagnostic in @percent@ of cases , CSM was diagnostic in @percent@ of cases , and orthostatic hypotension was present in @percent@ of cases.
T-type calcium channels are expressed in many diverse tissues , including neuronal , cardiovascular , and endocrine.
Tube formation on matrigel was higher in the presence of conditioned medium from young ADSC in comparison to aged ADSC.
Tuberculosis , acquired immune deficiency syndrome , leishmaniasis , and intestinal parasites were the most frequently associated infectious diseases.
Tuberculosis comprised @percent@ of the immunodeficiency-defining infections.
Tuberculosis DNA was not detected , and tuberculosis was not cultured either in the CSF.
Tube voltage , followed by tube current and the method of ECG-synchronization were the strongest independent predictors of radiation dose.
TUG1 is clearly associated with HK2 overexpression and unfavorable prognosis in HCC patients.
TUG1 negatively regulated miR-421 expression and promoted UV irradiation-induced SAR01 / 04 cell apoptosis.
Tukey honestly significant difference analysis revealed a significant difference in symptoms before and during tape adhesion and a significant difference during and after tape adhesion.
Tukey @percent@ showed that the LC group had the lowest µTBS.
Tukey's post hoc test demonstrated a statistically significant ( p < @number@ ) difference between the CN group and the other groups.
Tumor biological characteristics seem to be the main associated factor with breast cancer survival in our population.
Tumor cell metabolism is a promising target for various cancer treatments.
Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen.
Tumor cells exhibited small to medium-sized round to oval nuclei , with a smooth contour and indistinct or small nucleoli , and vacuolated cytoplasm.
Tumor characteristics were collected from medical records.
Tumor DNAs were extracted to assess exons 10-11 and 13-16 , and the intron-exon boundaries of the RET gene.
Tumor infiltrated type II ( M2 ) macrophages promote tumorigenesis by suppressing immune clearance , promoting proliferation , and stimulating angiogenesis.
Tumor infiltrating lymphocytes ( TIL ) reflect the host's anti-tumor immune response , and can be a valuable predictor of prognosis.
Tumor located in pancreatic head in @number@ patients and in pancreatic body and tail in @number@ patients.
Tumor location was available for @number@ patients , and the majority were supratentorial ( n = @number@ @percent@ ) .
Tumor necrosis factor-related apoptosis-inducing ligand ( TRAIL ) has the unique activity of activating cell death exclusively in tumor cells.
Tumor necrosis factor ( TNF ) is a proinflammatory cytokine known to mediate muscle atrophy in many chronic diseases and to inhibit skeletal muscle regeneration.
Tumor necrosis factor ( TNF ) plays an essential role in the pathogenesis of psoriasis , but its mechanism of action remains poorly understood.
Tumor necrosis factor ( TNF ) -α induces matrix metalloproteinases ( MMPs ) that may disrupt skin integrity.
Tumor necrosis factor-α expression was determined using quantitative PCR.
Tumor necrosis factor-α ( TNF-α ) inhibitors are increasingly being used as treatment for rheumatoid arthritis ( RA ) .
Tumor progression was detected in @number@ patients at @number@ @number@ and @number@ years after treatment , respectively , without significant symptoms.
Tumor progression was followed with T2-MRI , and animal survival and brain tissue histology were conducted.
Tumor registry records were used to identify patients and obtain clinical data ; surveys assessed participation and QOL.
Tumor response was assessed by reviewing follow-up brain imaging studies and classified according to the Response Evaluation Criteria in Solid Tumors.
Tumors are characterized by extracellular matrix ( ECM ) remodeling and stiffening.
Tumors from MDTG ; neu mice expressed Flag-Dmp1α and Ki-67 in a mutually exclusive fashion indicating that transgenic Dmp1α prevented tumor growth in vivo.
Tumor size was similar in the groups.
Tumors of hormone dependent tissues compose about 35-45% of the whole cancer morbidity.
Tumor stroma was laser capture microdissected from @number@ cases showing high stromal Cav-1 expression and @number@ cases with loss of stromal Cav-1.
Tumor suppressive effect of Klotho was determined by both in vitro and in vivo studies.
Tumor suppressor p53-dependent apoptosis is thought to be one of the most important tumor-suppressive mechanisms in human tumorigenesis.
Tumor suppressor PTEN , via dephosphorylation of Akt , was oxidized and inactivated by increased ROS.
Tumors were assessed in these offspring.
Tumors with EI ≥1.6 mJ·mL ( @number@ ) ·Gy ( @number@ ) showed a higher rate of complete response.
Tumor xenograft model revealed that HFS did not promote tumor growth.
Tumor xenografts revealed substantial reductions in tumor growth for both NHE1-ko and CA9-ko.
Tumour-associated osteomalacia is a paraneoplastic syndrome caused by renal phosphate wasting , leading to severe hypophosphataemia.
Tumour grade and stage were correlated with serological findings.
Tumours showed pronounced age-related expression in untreated animals older than @number@ days.
TUNA showed striking evolutionary conservation of both sequence- and CNS-restricted expression in vertebrates.
TUNEL assay revealed a significant increase in gracilis muscle apoptosis with aging.
TUNEL-positive nuclei were abundant at day @number@ fRPE exhibited substantial BM resurfacing at day @number@ with decreased resurfacing at later times.
TUNEL staining was variable.
Tungsten may contribute to lipid disorders.
Turnover in the Australian aged-care workforce is lower than in the United States but is still of concern.
Turnover is costly , especially in specialty settings.
TURP has the luxury of the longest follow-up , while less invasive forms of treatment starting to acquire long-term data.
TVH21 expression level showed a reduction expression in both men and women.
TV leaflets were the most extensible and isotropic , while AML and AV leaflets were the least extensible and the most anisotropic.
TV viewing time was self-reported at baseline and at follow-up.
TV viewing was positively related to 400-m walk time ( p < @number@ ) .
T was shown to be associated positively with men who were engaged in masturbation.
TWEETABLE ABSTRACT : Both DTCA and MCTA triplet pregnancies affected by TTTS are at high risk of adverse perinatal outcome.
Twelve age-matched untrained men ( O-Un ) and a group of young trained and young untrained men were recruited for comparison.
Twelve cadaveric hemiforehead flaps were stained using a modified Sihler method to trace the supraorbital and supratrochlear branches.
Twelve control subjects and @number@ PD patients were examined with PET using the 5-HT ( 1B ) -radioligand [ ( @number@ ) C ] AZ10419369.
Twelve dyads of matched elderly residents and their children participated in face-to-face , in-depth interviews ( N = 24 ) .
Twelve elderly GAD completed a 12-week pharmacotherapy trial.
Twelve healthy adults ( age < 55years ) and @number@ elderly ( age > 55years ) performed a motion direction discrimination task during EEG recording.
Twelve healthy and seven CAI participants completed two randomly assigned interventions.
Twelve healthy individuals of both sexes were enrolled in each age group.
Twelve Herculite XRV composite blocks were fabricated ( @number@ mm × @number@ mm × @number@ mm ) .
Twelve injuries involved the thoracic region ; @number@ the lumbar region ; and @number@ the thoracolumbar junction.
Twelve interviews and two focus groups were conducted , audiotaped , transcribed and analyzed for content.
Twelve items related to everyday technology use ( e.g. DVD player ) and @number@ related to advanced technology use ( e.g. Bluetooth ) .
Twelve measurements for each patient were averaged to form the best estimate of each eye's WFE and standard deviation.
Twelve men in HAY group and eight men in LAY group participated.
Twelve-month COPD-related and all-cause direct expenditures per beneficiary were US $ 7391 and $ 48 , 183.
Twelve-month old 3xTg-AD mice with plaques and tangles presented a significant upregulation of miR-181 in the hippocampus compared to age-matched wild type mice.
Twelve of the @number@ studies met inclusion and exclusion criteria and passed the appraisal point system cutoff.
Twelve of these transcripts remained differentially abundant in convalescence phase , and @number@ were similarly differentially abundant in acute phase of geriatric infectious diseases.
Twelve papers examined the impact of interventions on the outcome of depressive symptoms ; @number@ found a significant decrease in depressive symptoms.
Twelve patients additionally fulfilled the diagnostic criteria for posterior cortical atrophy and eight for logopenic variant primary progressive aphasia.
Twelve patients ( @percent@ ) and ten controls ( @percent@ ) had SPAD.
Twelve patients ( @percent@ ) underwent subsequent knee surgery.
Twelve patients undergoing biopsy because of asymptomatic hematuria or proteinuria had different diagnoses , but most of them already had significant chronic nephropathy.
Twelve patients were followed up 18-53 months ( @number@ months on average ) .
Twelve percent ( n = @number@ ) of care home residents were reported to be prescribed antipsychotic medications.
Twelve ( @percent@ ) patients reported improvement in symptoms.
Twelve persons with a genetically confirmed diagnosis of PWS aged over @number@ years are described ( @number@ deletion ; @number@ mUPD ) .
Twelve prospective cohort studies and two RCTs were included.
Twelve reported on microRNAs associated with exercise , and two reported on microRNAs associated with diet and weight loss.
Twelve residents were sent to an ED for care after the telemedicine visit.
Twelve skin malignancies occurred in five of the patients with prostate cancer.
Twelve studies met full inclusion criteria.
Twelve studies reported a significant association between executive functions and falls risk.
Twelve studies were included in the review , six of which were randomized controlled trials.
Twelve studies were included in the review ( study sample sizes 30-244 participants ) .
Twelve subjects ( @number@ male , @number@ female ; ages 65-76 yr ) were studied on four separate occasions , in double-blind , randomized order.
Twelve subjects undergoing surgery participated.
Twelve subjects with Alzheimer disease dementia were included for comparison.
Twelve themes were defined and compared across diagnostic status and Aβ status.
Twelve-week-old male ΔF508 mutants had lower body weight , improved oral glucose tolerance , and a trend toward higher insulin tolerance.
Twelve weeks of resistance-type exercise training significantly increased type II muscle fiber size and satellite cell content.
Twelve-year depression course trajectories serve as predicting variables and are specified according to recency and seriousness.
Twelve young ( 18-35 years ) and older ( 65-85 years ) men and women were studied at baseline.
Twelve young and @number@ old adults observed two cue events and responded to a target event on each of a series of trials.
Twelve young and twelve elderly cognitively healthy subjects participated in the study.
Twenty adults with DS and their parents / caregivers were a part of a longitudinal study , which provided two time points of data.
Twenty asymptomatic adults ( [ Formula : see text ] = @number@ ) performed multiple @number@ m timed up and go.
Twenty community-dwelling older adults were recruited and enrolled in either a spin exercise group or a control condition.
Twenty completed the follow-up post-test Hospital Anxiety and Depression Scale questionnaire including @number@ of the @number@ who had tested positive.
Twenty composite resin cylinders were bonded to each group with Panavia F @number@
Twenty-eight compounds , which have not been described before in Bartlett pears or in fermented pear mash , were identified.
Twenty-eight healthy older participants underwent a resting-state functional magnetic resonance imaging scan and an emotional face-name encoding task.
Twenty-eight hypertensive patients and @number@ elderly controls were tested with n-back task with two load levels.
Twenty-eight kinematic indices were computed from four tasks.
Twenty-eight loosely structured interviews were conducted.
Twenty-eight of @number@ met HAND criteria.
Twenty-eight% of octogenarians had multimorbidity but only @percent@ had some I-ADL disability.
Twenty-eight older people ; @number@ with PD and @number@ neurologically healthy individuals ( control group ) , participated in the study.
Twenty-eight patients were included in our study ; @percent@ of the patients were female and @percent@ were male.
Twenty-eight patients were over @number@ years old.
Twenty-eight percent of the patients had a convex malar prominence postoperatively compared with @number@ percent preoperatively.
Twenty-eight studies ( @number@ regarding BMD and @number@ fractures ) followed a total of @number@ participants for a median of @number@ years.
Twenty-five and eighteen protein spots were differentially expressed in HC1 and HC2 classes , respectively.
Twenty-five human participants with MCI and @number@ matched healthy volunteers underwent diffusion MRI , behavioral assessment , and volumetric measurement of the basal forebrain.
Twenty-five of the pneumonia patients ( @number@ % ) were smokers , and @number@ ( @number@ % ) had underlying pulmonary diseases.
Twenty five participants with diagnosed unilateral medial knee OA and @number@ healthy participants , with no known knee pathology were recruited.
Twenty-five participants with mild dementia and @number@ controls carried out a street-crossing task in a simulated environment.
Twenty-five patients had associated diseases : diabetes in @number@ patients and malignant tumors in seven.
Twenty-five patients had osteoporotic fractures and @number@ had pathological fractures.
Twenty-five patients ( @percent@ ) completed the study , and compliance to the exercise program was @percent@.
Twenty-five patients ( @percent@ ) were able to play the same amount of golf or more than before fusion surgery.
Twenty-five patients who fulfilled the criteria for the study were analyzed for brow-position changes in height and shape.
Twenty-five studies were identified including a total of @number@ predominantly female , overweight / obese participants ( @percent@ ) .
Twenty-five studies were included in the review.
Twenty-five subjects had HTN.
Twenty-five untrained men and forty-seven untrained women aged @number@ ( range : 67-93 ) years were recruited.
Twenty-four adults aged 20-63 years participated.
Twenty-four articles were selected from available evidence.
Twenty-four caregivers ( @number@ intervention and @number@ attention control ) participated.
Twenty-four female subjects of three age groups were enrolled.
Twenty-four healthy , Caucasian , @number@ to 75-year-old men and women ( menopausal or sterilized ) with advanced photoaging were included.
Twenty-four healthy volunteers completed 3-Tesla magnetic resonance imaging and high-resolution [ ( @number@ ) C ] raclopride PET scans.
Twenty-four-hour Holter monitoring was carried out.
Twenty-four informal caregivers participated in the study.
Twenty-four of the @number@ indices showed an improvement during childhood.
Twenty-four participants who completed at least four sessions participated in the post-evaluation follow-up.
Twenty-four patients were enrolled , and @number@ patients completed the study.
Twenty-four patients with unilateral vestibular deficit were included.
Twenty-four people were recruited via snowball sampling.
Twenty-four preserved human elbows were carefully dissected and the insertions of the biceps conserved.
Twenty-four SNPs located within the @number@ and @number@ regions of @number@ genes were analyzed.
Twenty-four staff participated in FGs ( n = @number@ ) , which were audio recorded , manually transcribed , and thematically analyzed.
Twenty-four subjects with mild cognitive impairment were compared with @number@ matched controls.
Twenty-four substances ( @percent@ ) fell short of the consensus cutoff and were re-evaluated in a second round.
Twenty-four variants were selected for follow-up in an independent dataset ( UK Biobank , N = @number@ @number@ ) .
Twenty-four weeks of whole body vibration or MTs result in positive modifications in total fat mass.
Twenty-four younger adults ( 20-30years ) and @number@ older adults ( 61-76years ) participated in this study.
Twenty-four younger and twenty-four older adults with matched verbal fluency , verbal intelligence , years of education , and gender ratio were recruited.
Twenty health professionals from varied backgrounds were interviewed.
Twenty healthy individuals of each age group ( 11-20 ; 21-30 ; 31-40 ; 41-50 ; and 51-60 years ) were selected randomly.
Twenty healthy older ( mean age @number@.5±2.9 ) and twenty young ( @number@.3±2.8 ) adults participated in this study.
Twenty healthy young adults ( mean age , @number@ years ) and @number@ healthy older adults ( mean age , @number@ years ) were studied.
Twenty male and female subjects ( @number@ - 20-35 years , @number@ - 40-70 years ) were examined.
Twenty matched younger adults served as controls.
Twenty men were interviewed.
Twenty-nine articles were included in the qualitative synthesis.
Twenty-nine differentially abundant transcripts were identified in acute phase versus healthy ageing.
Twenty-nine institutionalized older adults ( @number@ men and @number@ women ) with depressive symptoms varying from mild to severe constituted the sample.
Twenty-nine of them ( @percent@ ) received neoadjuvant chemotherapy.
Twenty-nine patients ( @percent@ ) presented thyroid dysfunction : @number@ ( @percent@ ) had hypothyroidism , and two ( @percent@ ) had hyperthyroidism.
Twenty-nine per cent of clinics had an internationally recognised accreditation.
Twenty-nine younger adults and @number@ cognitively normal older adults completed a working memory paradigm while functional magnetic resonance imaging was performed.
Twenty nursing home units in one city in Norway will be recruited and allocated to intervention or control by an independent statistician using computer-generated tables.
Twenty older adults and @number@ healthy young adults participated in the study.
Twenty older adults ( @number@.9±3.5years ) stood with feet together on a force platform for 60s while performing randomly assigned discrete and continuous cognitive tasks.
Twenty older adults participated in the study.
Twenty older adults were trained for over @number@ h to play Rise of Nations , a complex real-time strategy game.
Twenty-one children in the 4th grade volunteered to participate in the experimental ( n = @number@ ) or control ( n = @number@ ) group.
Twenty-one community providers completed the training.
Twenty one different mutations were identified including @number@ novel ones.
Twenty-one elderly women ( mean age ± SD , @number@ ± @number@ years ) participated in @number@ weeks of resistance exercise training.
Twenty-one HIV patients underwent THA for AVN.
Twenty-one members over @number@ generations composed the pedigree.
Twenty-one of the @number@ individuals never scored outside the ' normal ' range ; however , medications were given to @percent@.
Twenty-one of these were cardiac events.
Twenty-one patients ( male = @number@ female = @number@ ) with siCADs were included.
Twenty-one patients were administered unfractionated heparin in the perioperative period ( heparin group ) .
Twenty-one ( @percent@ ) had Parkinson's disease alone and two ( @percent@ ) had an additional movement disorder.
Twenty-one variants in IRS-1 and @number@ in IRS-2 were identified in the CRC samples.
Twenty-one women were interviewed regarding their caregiving experiences for ill or dying ex-husbands.
Twenty participants in each age group received training with a visuospatial WM task , whereas the others served as active controls and completed alternative activities.
Twenty participants repeated the trials for reliability purposes.
Twenty participants studied compound words and unrelated word pairs during encoding.
Twenty participants were interviewed in-depth , and data were analyzed using content analysis.
Twenty patients , matched aged , with vascular ED who did not accept to undergo the standard PhA's protocol , represented the control group.
Twenty patients received a single-session , single-pass , ablative fractional treatment on a split face.
Twenty patients received trimebutine @number@ mg three times daily half an hour before meals.
Twenty patients with moderate-severe hip OA ( grade II-IV according to Kellgren-Lawrence score ) were enrolled in the study group.
Twenty patients with Parkinson's disease participated in this study.
Twenty percent of respondents reported difficulty getting equipment ready for use , and @number@ percent had difficulty cleaning equipment.
Twenty percent of the patients died within @number@ months ( average age , @number@ ± @number@ yr , range , 76-88 yr ) .
Twenty RCTs met the inclusion criteria.
Twenty reviews ( @number@ SLRs and @number@ MAs ) , mostly of moderate methodological quality , were found eligible.
Twenty-seven articles met criteria for review.
Twenty-seven carers between the ages of @number@ and @number@ years responded to questionnaires about demands , resources , and their health.
Twenty-seven healthy adults underwent fMRI while performing a speech production task consisting in the articulation of nonwords of different sequential and motor complexity.
Twenty-seven major drug interactions were identified and eight interactions involved chemotherapy.
Twenty-seven older adults participated and were instructed to walk on a narrow path projected on a treadmill.
Twenty-seven older adults participated in face-to face interviews.
Twenty-seven older and @number@ younger adults descended a purpose-built staircase.
Twenty-seven participants had no biomarkers of Alzheimer dementia and were CDR = @number@
Twenty-seven percent of patients died during the study period.
Twenty-seven subjects in the ET group and @number@ in the CON group completed the study.
Twenty-seven Swedish informants were interviewed using an interviewing guide that included a photographic survey.
Twenty-seven used the macrotensile test with @number@ AS , and @number@ used the macroshear test with @number@ AS.
Twenty-seven young ( @number@.2±4.5yrs ) and twenty-three elderly ( @number@.2±5.0yrs ) subjects were asked to stand quietly on a force plate for five trials.
Twenty-six aMCI patients and eighteen matched healthy subjects were evaluated at baseline and at mean @number@ months follow up.
Twenty-six candidate proteins were quantified in @number@ subjects using multiplex ( xMAP ) assays.
Twenty-six drivers ( 55-78 yr old ) were randomly assigned to either an exercise group or a control group.
Twenty-six gene variants were investigated across candidate gene studies and @number@ studies used a genome-wide association approach.
Twenty-six healthy elderly females leading a sedentary lifestyle were assigned to a DDR , brisk walking , or control group.
Twenty-six men and @number@ women were divided into two age groups.
Twenty-six OAs without and @number@ with MCI completed the Stroop task during functional neuroimaging , and completed additional out-of-scanner neuropsychological measures.
Twenty-six older overweight sarcopenic men ( @number@ ± @number@ years old ) were recruited for the study.
Twenty-six participants completed the study.
Twenty-six patients had paralysis.
Twenty-six patients ( @percent@ ) experienced MACE.
Twenty-six patients ( @percent@ ) had major or minor postoperative morbidity , and one ( @percent@ ) died due to bronchopleural fistula.
Twenty-six patients were eventually diagnosed with AMI.
Twenty-six patients with sporadic Creutzfeldt-Jakob disease and nine age- and gender-matched healthy control subjects underwent volumetric T1-weighted and diffusion tensor imaging.
Twenty-six ( @percent@ ) had other ( general medical / cardiac ) causes ; of these @number@ ( @percent@ ) also had vestibular causes.
Twenty six percent of participants regained balance performance within normal limits similar to those achieved in the previous RCT.
Twenty-six persons ( @percent@ ) , most of whom were @number@ years of age or older , had at least @number@ CMB during the study.
Twenty-six studies ( @number@ participants ) were suitable for the quantitative synthesis.
Twenty-six studies were considered for the review , from @date@ to @date@ .
Twenty-six studies were included with @number@ cases of PCa reported from @number@ participants.
Twenty-six subjects completed the study.
Twenty-six subjects ( Group B ) received only full face treatments with the same non-ablative , fractional laser device.
Twenty-six subjects received four ELOS Triniti™ treatments at 1-month intervals.
Twenty students representing six professions completed the course ; @number@ completed all self-efficacy and course evaluation surveys.
Twenty studies ( @number@ longitudinal studies = 551 participants ; @number@ RCTs = 328 treated vs. @number@ controls ) were included.
Twenty studies were included in this systematic review , of which twelve provided sufficient data to determine effect sizes for the effect of age.
Twenty subjects with forehead / glabellar rhytide complex ( static and dynamic creases ) enrolled.
Twenty subthemes emerged on factors that affect QOL.
Twenty teeth from each group were subjected to tensile test , failure pattern after debonding and evaluation of resin / enamel interface.
Twenty-three autopsy-confirmed LBD cases with an MRI scan close to death ( mean @number@ years ) were studied.
Twenty-three children and adolescents who received an allogeneic HSCT were recruited from a pediatric teaching institution in the southern United States.
Twenty-three key stakeholders with particular insights into the current situation of the health workforce were purposively recruited for in-depth interviews.
Twenty-three of the @number@ Optimal performers had longitudinal data and16 maintained top memory performance while @number@ declined.
Twenty-three papers satisfied the inclusion criteria.
Twenty-three patients had eEVAR and @number@ had OPEN surgery.
Twenty-three patients ( @percent@ ) required an additional correction @number@ month after the primary treatment.
Twenty-three patients were treated for acute proximal humerus fractures ( @number@ reverse total shoulder arthroplasties and @number@ hemiarthroplasties ) .
Twenty-three patients with insomnia disorder and @number@ healthy age- and sex-matched control subjects participated in the study.
Twenty-three percent of the patients had a complex diagnosis.
Twenty trials examined immunological outcomes and found few relevant differences.
Twenty-two articles met all study inclusion criteria.
Twenty-two articles were included in the review.
Twenty-two female MA ( age = @number@ ± @number@ ) participated in this double-blind design.
Twenty-two healthy adults dialed a cell phone during treadmill walking at a self-selected speed while kinetic , kinematic , and spatial parameters were recorded.
Twenty-two healthy young and @number@ older adults participated in this study and performed forward reaching under two task conditions.
Twenty-two hospitals had an ICU that routinely cared for children ; @number@ had dedicated pediatric ICUs.
Twenty-two men aged 50-85 years participated , data were analyzed by hermeneutical interpretation with Gadamer's approach.
Twenty-two non-demented patients with PD underwent neuropsychological testing and lumbar puncture to collect CSF.
Twenty-two of @number@ SMT patients with DNI orders received NIV as a rescue therapy.
Twenty-two older adults aged 60-70 ( PLY n = 9 , PNE n = 11 ) participated in the study.
Twenty-two older adults completed two testing sessions.
Twenty-two older patients participated voluntarily in this study.
Twenty-two participants with UHR and @number@ HC were enrolled in this study.
Twenty-two patients ( mean age @number@ years ) were available for follow-up.
Twenty-two patients ( @percent@ ) experienced hardware-related complications.
Twenty-two patients still survived after mean follow up of @number@ months ( @number@ - @number@ months ) .
Twenty-two patients were treated with arthroscopic Hyalograft C implantation , and @number@ underwent the open Chondro-Gide MACI procedure.
Twenty-two ( @percent@ ) had a radiologically demonstrated urinary tract abnormality.
Twenty-two ( @percent@ ) MS patients were cognitively impaired ( CI ) .
Twenty-two percent of the patients reported an NRS of @number@ as the highest value following their injury.
Twenty-two percent of the symptomatic group and @percent@ of the asymptomatic group required halo , fusion , or other surgical intervention.
Twenty-two SNPs showed significant associations for verbal storage ( forward digit span ) a trait linked to phonological span.
Twenty-two SNPs were associated with fatal PCa incidence , but most did not differentiate between fatal and nonfatal PCa.
Twenty-two studies investigated license renewal and seven articles examined medical reporting.
Twenty-two studies ( @number@ observational studies and @number@ controlled trials ) were included from @number@ evaluated references.
Twenty-two voluntary elderly had postural control assessed under different conditions of skin stimulation.
Twenty-two women with clinical and ultrasound signs of moderate photoaging were enrolled in the study.
Twenty-two young healthy controls ( YHC ) , @number@ age-matched old healthy controls ( OHC ) and @number@ patients with stable CHD were recruited.
Twenty typically developing children divided into @number@ groups , older and younger than @number@ years old , participated in this study.
Twenty years ago , chromosomal abnormalities were the only identifiable genetic causes of a small fraction of congenital heart defects ( CHD ) .
Twenty young and @number@ older adults completed three cognitive tasks ( switch task , Stroop task and ) .
Twin models were fit to estimate the correlation of genetic and environmental contributions to depression and diabetes.
Twin studies have shown that longevity in humans is moderately heritable with a genetic component of 25-32%.
Twin studies indicate substantial inherited components in cognitive abilities.
Twin studies in the past two decades proved to be a very powerful tool to discriminate the genetic from the environmental component.
Two 24-hour recalls were collected by trained interviewers using the US Department of Agriculture automated multiple pass method.
Two 24-week , double-blind , randomized , placebo-controlled intervention studies were carried out in parallel.
Two additional cohorts ( @number@ premenopausal , @number@ postmenopausal ) , who had only ever delivered by pre-labor cesarean , were identified for comparison.
Two additional measures assess cognitive status : short-term memory problem and a diagnosis of non-Alzheimers dementia.
Two additional themes not covered by CSRQ on dynamics and reciprocity of social relations were identified.
Two age groups of young and old adult participants were tested.
Two age groups were studied ( younger age group = 65-75 ; older age group = 76 + ) .
Two aging indicators were assessed at age @number@ years , objectively by leukocyte telomere length ( TL ) and subjectively by perceived facial age.
Two algorithms , named IIS-LLD and CPNN , are proposed to learn from such label distributions.
Two alternative MK2-23 plasmids format V H / V L , and V L / V H were assembled.
Two antagonist muscles tibialis anterior ( TA ) , and extensor digitorum longus ( EDL ) were also recorded.
Two antibodies ( HT4 and HT52 ) inhibit LPS-induced human TLR4 activation via novel LPS binding-independent mechanisms.
Two applications are used to evaluate the efficacy of the complexity measures : diagnosis of autism and aging , both based on EEG.
Two approaches were adopted.
Two attempts per load were performed , with a third attempt when F-V points deviated from the linear F-V regression equation.
Two atypical clinical epileptic syndromes should be pointed out in the elderly : the transient epileptic amnesia and the epileptic pseudodementia.
Two authors independently assessed study quality and extracted data.
Two authors independently extracted data and assessed methodological quality.
Two authors independently reviewed articles to select eligible studies and performed data abstraction.
Two authors will independently collect detailed information using structured data abstraction form.
Two available hand-pieces with different focal depths ( @number@ mm and @number@ mm ) were used with three to five passes 1-2 mm apart.
Two axis of collaboration have been raised : @number@ ) The identification of the determinants in Aircraft aging ( structural aging ) .
Two brain structures , differentially vulnerable to LOAD pathology , were examined in @number@ brain samples from @number@ neurologically normal individuals.
Two cardiologists independently adjudicated the final diagnosis of AHF after reviewing all available baseline data excluding the biomarkers.
Two case reports of patients using low-concentration tretinoin gel @percent@ for the treatment of photodamaged skin are discussed.
Two case studies illustrate the impact of the economic reforms on older persons.
Two centuries ago , the German bacteriologist Robert Koch proposed three postulates to support a causal relationship between a specific microbe and an infectious disease.
Two ceramic veneers showed cracking in the labial area.
Two classical tumor suppressors , p53 and pRB , control cell cycle arrest associated with senescence.
Two colonies of mice ( @number@ transgenic for SB3 and @number@ C57BL / 6J controls ) have been studied.
Two commonly used devices were tested : MINI ( Applied Medical Technology Inc. ) and MIC-Key ( Kimberly Clark / Ballard Medical ) .
Two common mutations , F188del and R179 account respectively for about @percent@ and @percent@ of patients with the HHH syndrome.
Two comparative groups were included : age-matched controls and children with other neurological diseases.
Two complementary approaches are used to identify persons with persistent disability , one based directly on observed data and the other on latent classes.
Two complementary methodologies , nominal group technique and focussed ethnography , were used to identify barriers and facilitators and rank their importance.
Two complications ( hemothorax and superficial wound infection ) occurred.
Two components of flexibility were distinguished : maintenance of a categorical relation , and switching between two relations.
Two compounds were tested for their antiproliferative effects in breast cancer ( MCF-7 ) and lung carcinoma ( A549 ) cell lines.
Two concentrations of P407 gel were fabricated , @number@ and @percent@ w / w.
Two conditions , commonly occurring together , that contribute to this burden are hypertension and diabetes mellitus.
Two control knees per case were selected from those eligible for WKROA that did not develop it.
Two cornerstones of therapy for postmenopausal hormone therapy and calcium plus vitamin D supplementation- were rigorously studied.
Two decades of epidemiological research shows that silent cerebrovascular disease is common and is associated with future risk for stroke and dementia.
Two deterministic models fit the resulting age trajectories of mortality on either side of the strong mortality minimum.
Two different phenotypes were identified among affected members , CBS in the proband and FTD in his brother.
Two different stem cell populations of interest are mononuclear umbilical cord blood cells and menstrual blood-derived stem cells.
Two-dimensional distribution of the material in the horizontal and in the vertical axes was quantified using fluoroscopic imaging.
Two-dimensional gel electrophoreses with overlapping IPGs were used to improve the separation of muscle proteins.
Two-dimensional multivoxel 1H-magnetic resonance spectroscopy scans were performed before and after stimulation.
Two-dimensional speckle-tracking echocardiography was used to assess LA reservoir function , reflecting LA compliance.
Two-dimensional surface-viewed images of the skin showing MR patterns were obtained using dry dermoscopy.
Two direct composite veneers lost retention.
Two directions of frequency change , rising or falling , were used for each of three rates of frequency change.
Two directions of neuroimaging studies on the relationships between sex / gender and autism may inform male-specific risk mechanisms and female-specific protective mechanisms of autism.
Two distinctly different sleep patterns emerged : good but declining sleep quality and disrupted sleep quality.
Two distinct miR-339-5p target sites were predicted in the BACE1 @number@'-UTR by in silico analyses.
Two domains of depressive symptoms negative affect and lack of positive affect were measured using a 10-item version of the Center for Epidemiologic Studies-Depression Scale.
Two dominating discourses was found.
Two DTI indices were analyzed including fractional anisotropy ( FA ) and mean diffusivity ( MD ) .
Two duration bisection experiments that address this issue are reported.
Two EAK proteins , EAK-2 / HSD-1 and EAK-7 , influence C. elegans lifespan and are conserved in mammals.
Two episodes of azole-resistant IA ( @percent@ ) were caused by a TR / L98H mutation in the cyp51A gene.
Two estrogen receptors-α and β-have been cloned and found in various tissue types.
Two ethnographic examples document the ways in which those factors are lived in treatment discussions and in expectations about death and longevity.
Two European Union-funded research projects , Full4Health and SATIN , are adopting these complementary approaches.
Two examples of areas where we have seen much advancement are discussed.
Two experimental conditions , of @number@ seconds each , were investigated : opened eyes and closed eyes.
Two experiments compared effects of integrative and semantic relations between pairs of words on lexical and memory processes in old age.
Two experiments examined how 10- and 12-year-old children and adults intercept moving gaps while bicycling in an immersive virtual environment.
Two experiments examined how sensory acuity affects age differences in susceptibility to interference in the reading-with-distraction task.
Two experiments examined how the different cues to gaze direction contribute to children's abilities to follow and make explicit judgements about gaze.
Two experiments tested the effect of temporal interference on order memory for fixed and random sequences in young adults and nondemented older adults.
Two experiments tested the hypothesis that differentiation from one's age group reduces the impact of negative age-related information on older adults ' self-evaluation.
Two experiments were run to determine whether two executive functions-inhibition and shifting capacities-mediate age-related differences in strategy repertoire and in strategy selection.
Two expert shoulder surgeons and @number@ expert trauma surgeons reviewed @number@ consecutive PHFs surgically treated at another institution.
Two-factorial ANOVAs served to examine the age and gender-specific effects , and models from Generalizability Theory ( G-Theory ) were used for assessing retest-reliability.
Two factors in particular that can influence immune function are the single nucleotide polymorphisms ( SNPs ) and aging.
Two factors were especially noteworthy.
Two factors were identified.
Two fall models were developed for active and passive falls using acceleration data.
Two features of the EFEs were contemplated , their valence ( operationalized in six basic emotions ) and five levels of intensity.
Two female subjects gave informed consent for RF treatment for the right upper eyelid and no treatment for left upper eyelid.
Two focus groups were conducted with a sample of @number@ participants , with either recent or chronic OA , at one or multiple sites.
Twofold increases in thermal diffusivity and size reduction were found in the linear PT response during cell death.
Two food patterns labeled \ "traditional-western food pattern \ " and \ "green food pattern \ " were identified.
Two forms of SAM are classically distinguished : kwashiorkor and marasmus.
Two forms of structural social capital , i.e. informal socializing and social participation , were measured.
Two frailty scores were compared - cumulative deficit frailty index ( PHS FI ) and modified Study of Osteoporotic Fracture ( mSOF ) frailty score.
Two graders were given a set of @number@ images to grade using a GUI that included sample images for each of the six grades.
Two groups : @number@ - subjects whose VA has exceeded CA for at least @number@ years and @number@ - others were established.
Two groups of participants ( group 1 : 290 participants ; group 2 : 56 participants ) were evaluated in this study.
Two groups of patients were compared ( patients with and without delirium ) using both univariate and multiple logistic analyses.
Two groups of potential predictors were examined for inclusion in the models.
Two groups of younger subjects used a high-end ( Omega.3 ) and a low-cost ( Falcon ) device respectively.
Two groups recently reported the successful generation and characterization of induced pluripotent stem cells ( iPSCs ) from HGPS fibroblasts.
Two groups showed similar immunogenicity , the neutralizing antibody titer of all subjects at D14 and D42 showed > 0.5 IU / ml.
Two groups were established comparing those who received NPWT alone to those who received NPWT plus CCO.
Two groups were formed according to age at the time of admission.
Two groups were identified : high DJD pain and low DJD pain.
Two groups were significantly associated with development of cognitive impairment.
Two hundred and eight adults ranging from @number@ to 79years old segmented movies of everyday events and attempted to remember the events afterwards.
Two hundred and fifty-five women were available for analyses ; @number@ BRCA1 / 2 mutation carriers and @number@ proven non-carriers.
Two hundred and fifty-seven older people were involved and a multistage random sampling method was utilised.
Two hundred and forty-two people aged @number@ years and above receiving home nursing care participated in the study.
Two hundred and seven men aged 54-86 years were studied.
Two hundred and thirty-one participants from the GENFI study were included : @number@ presymptomatic MAPT , GRN , and C9orf72 mutation carriers and @number@ non-carriers.
Two hundred and twenty individuals were enrolled in this study and divided into five groups according to age.
Two hundred and twenty-nine men ( @percent@ ) and @number@ women ( @percent@ ) were taking no medications.
Two hundred and two patients ( @percent@ ) were ART experienced and @number@ ( @percent@ ) ART naive.
Two hundred autopsied , non-atrial fibrillation hearts ( @percent@ deriving from females ) whose donors were a mean of @number@.6±17.6years old were investigated.
Two hundred eighty-four consecutive AD patients were enrolled.
Two hundred eighty-six patients were screened.
Two hundred fifty-four older community dwellers ( @number@ ± @number@ years ) underwent structural magnetic resonance imaging , CSRT tests , neuropsychological and sensorimotor assessments.
Two hundred forty-three healthy , non-ambulatory outpatient men with chronic SCI from age of @number@ to @number@ years were included in this retrospective analysis.
Two hundred GP and @number@ MS subjects completed the questionnaire.
Two hundred medical inpatients living in the community and aged over @number@ years were included.
Two hundred participants completed two versions of the SAI , a Likert format and dichotomous format.
Two hundred sixteen CKD patients ( @number@ men and @number@ women ) were enrolled in this cross-sectional study.
Two hundred sixty-six FNC samples from @number@ BC patients have been reviewed.
Two-hundred ten FTLD patients underwent clinical and a wide standardized neuropsychological examination as well as brain imaging.
Two hundred ten participants ( @number@ ± @number@ years , @percent@ women ) were assessed at baseline and 1-year follow-up.
Two hundred thirteen subjects ( @percent@ ) had soft drusen ( 97 / 271 women , 116 / 367 men ) .
Two hundred thirty-four ( @percent@ ) reported ablation was offered at their institution , although only @number@ ( @percent@ ) ever participated in this procedure.
Two hundred thirty-two individuals were CSF-positive and @number@ CSF-negative.
Two hundred twenty-four ( @percent@ ) residents noted exposure to surveillance for managing SRMs , increasing from @percent@ in U1 to @percent@ in U5.
Two important clinical trials of sub-lobar resection for small peripheral lung cancers are now underway in Japan.
Two important mechanisms which regulate protein stability and degradation are lysine acetylation and ubiquitination , respectively.
Two independent analysts thematically coded transcribed interviews.
Two independent assessors performed quality assessment using the QUADAS-2 tool plus some additional items to assess the methodological quality of the included studies.
Two independent authors searched PubMed and Scopus from inception until @date@ .
Two independent , cross-sectional single scanner cohorts of healthy subjects were included.
Two independent evaluators determined the epidermal and dermal thickness and the depth of necrosis ( micrometre ) .
Two independent observers visually evaluated the malar prominence and nasolabial fold improvements based on standardized photographs.
Two independent researchers searched for relevant papers across multiple , cross-disciplinary electronic databases using previously validated search strings.
Two independent reviewers abstracted data using pre-defined terms.
Two independent reviewers appraised study quality.
Two independent reviewers extracted data and assessed the quality of included studies.
Two independent reviewers extracted descriptive information on the prevalence and co-occurrence of frailty and depression in older individuals and of frailty criteria among depressed patients.
Two independent reviewers reviewed abstracts for inclusion.
Two independent reviewers screened abstracts , applied inclusion criteria , and appraised study quality.
Two independent reviewers searched major electronic databases and extracted data on studies reporting quantitative correlates of PA participation in community dwelling adults with dementia.
Two indices including normalized crest time ( NCT ) and crest time ratio ( CTR ) were also analysed and compared with the known parameters.
Two individuals in each of these organizations were selected for interview.
Two instrumental variables , based on region and urologist prescribing preference , were constructed and analyzed using exogenous probit models.
Two interaction terms in the regression on work motivation were significant.
Two investigators extracted the data and assessed the quality of the included literature independently.
Two investigators independently abstracted study characteristics and assessed the methodological quality of eligible studies.
Two investigators independently coded data and performed thematic content analysis.
Two investigators independently coded transcripts for thematic content using editing style analysis.
Two investigators systematically searched major electronic databases , from inception until @date@ .
Two isoforms exist in higher eukaryotes , CAP1 and CAP2.
Two isoforms have been identified , but only GHS-R1a binds with acyl ghrelin and transduces its message.
Two large genome-wide association meta-analyses of individuals of European descent were recently published , revealing ~13 new loci for BP traits.
Two late-onset patients carrying D337E and p. L341V mutations had bulbar and limb onset , respectively.
Two lines expressing high ( Line @number@ ) and low ( Line @number@ ) levels of the three-repeat mutant Tau were analyzed.
Two lingering problems regarding transplantation in older adults have been how to select patients appropriately and whether to use older sibling donors.
Two loci , ADRB1 and AGT , contain single nucleotide polymorphisms that reached a genome-wide significance threshold in meta-analysis for the first time.
Two main classes of senescent cells have been identified : acute and chronic senescent cells.
Two main factors have been identified as modulators of such differences : proficiency and age of acquisition of the second language ( L2 ) .
Two main results were found.
Two major apoptotic pathways have been extensively studied which are the mitochondrion-mediated and receptor-mediated pathways.
Two major categories and multiple themes emerged.
Two major forms of collagen XXVIII were identified , Col28a1b in adult and Col28a2a in 3-5dpf zebrafish.
Two major issues need to be addressed in applying semiconductor biosensors to detecting proteins in immunoassays.
Two major themes were identified.
Two mathematical representations are proposed.
Two measures of verbal working memory were collected : digit span and serial recall of words.
Two mechanisms for the evolved adaptation have been proposed , the ' mother effect ' and the ' grandmother effect'.
Two median splits were conducted based on each individual's performance for the 10MWT and TUG.
Two men were excluded after suicide death.
Two modalities were applied , and observers were asked to use only whole digits and then half digits for grading.
Two models were created to assess GS alone and from inclusion in the SPPB.
Two models were developed using these data.
Two molecules of inhibitor @number@ were found to interact with furin.
Two-month-old infants showed no significant object-related response.
Two morphologically distinct Demodex species parasitize on humans : Demodexfolliculorum ( Simon , @number@ ) and Demodex brevis ( Akbulatova , @number@ ) .
Two narrow cohorts have been selected for comparison , and health was measured by self-reported longstanding limiting illness.
Two neuroretinal parameters , minimum rim width and retinal nerve fiber layer thickness , in addition to peripapillary choroidal thickness were measured.
Two new functional hierarchies are presented , an IADL hierarchical capacity scale and a combination scale integrating both IADL and ADL hierarchies.
Two new studies suggest a new role for 53BP1 as an inhibitor of HR [ @number@ ] .
Two new summary HC-QI scales , the \ "Independence Quality Scale \ " and the \ "Clinical Balance Quality Scale \ " are derived.
Two normalization techniques were separately implemented and evaluated : maximum voluntary EMG ( MVE ) and neck cross-sectional area ( CSA ) .
Two novel antifibrotic agents , pirfenidone and nintedanib , have received licences for use in IPF in recent years.
Two novel MAPT mutations IVS10 + 4A > C and the IVS9-15T > C transmitted by the unaffected parents were identified.
Two novel missense variants of unknown significance in the MAPT and GRN were detected in each gene.
Two of @number@ probands were from an autosomal dominant early onset Alzheimer's disease ( familial Alzheimer's disease ) pedigree.
Two of the films challenge the notion of a heteronormative old age.
Two of the girls had pronounced neonatal progeroid features and were initially diagnosed with Wiedemann-Rautenstrauch syndrome.
Two of the main redox-sensitive signaling pathways altered in old skeletal muscle during exercise , NF-κB and PGC-1α , are also reviewed.
Two of the major risk factors for CVD are advancing age and obesity.
Two of them coauthored papers , in collaboration with Russian researchers , and created institutions to promote discussion on trepanation.
Two of the most common symptoms of patients at ICU admission were fever ( @number@ % ) and cough ( @number@ % ) .
Two of the @number@ subjects were male.
Two of the @number@ type IV patients still required blepharoplasty / ptosis surgery.
Two of these are identified as the @date@ and @date@ isoforms , with the latter predominating.
Two of these could be described as dark scenarios with very poor prospects.
Two of these factors ( age and fracture history ) also predict risk for total fractures in women irrespective of race-ethnicity.
Two of these five articles reported functional limitation ( low gait speed ) in PLHIV.
Two of these patients also experienced acute neurologic deficit.
Two of these patients showed cerebrospinal fluid pattern of amyloid beta , tau , and phosphorylated-tau suggesting underlying Alzheimer's disease ( AD ) pathology.
Two of the seven patients are on dialysis because of chronic allograft nephropathy.
Two of this paper's authors , F Pompei and R Wilson , contributed to the original article.
Two of three studies reporting grip strength reported lower grip strength ( nearly @number@ kg ) in PLHIV in comparison with uninfected patients.
Two open-ended life events questions were categorized and grouped into different life event domains.
Two or more cardiovascular risk factors were reported by @percent@ of survivors and @percent@ of siblings.
Two other useful parameters are also computed from the same measurements.
Two outcomes were studied using binary and ordered logistic regression ; use of alcohol and frequency of use among alcohol users.
Two out of @number@ malnourished older adults were physically frail , whereas close to @percent@ of the physically frail older adults was identified as malnourished.
Two papers have recently shown that despite this extremely complex control , telomere length can be manipulated by external stimuli.
Two-part generalized linear models were used to estimate and compare mental health service use among adults with and without a comorbid general medical illness.
Two participants had infratentorial SS , restricted to the posterior fossa.
Two participants with Alzheimer's disease learned how to use AP@LZ in their daily lives by following a structured learning method.
Two participants with different psychological profiles , who benefited differently from the intervention , are then presented in more detail.
Two participants with normal SM and MPF levels presented afterward with mesothelioma and lung cancer , respectively.
Two patients died.
Two patients experienced profound but reversible near-syncope during the procedure.
Two patients from Group B had wound dehiscence , but finally their wounds healed uneventfully.
Two patients from @number@ family had a novel heterozygous missense mutation in the PSEN1 gene ( p.F386L ) .
Two patients had an intraepithelial melanosis of the conjunctiva , and one showed conjunctival nevi.
Two patients had corneal scars and corneal vascularisation , another a significant conjunctivalisation of the cornea.
Two patients had undergone microinjection of the same branded topical moisturizer ( Vita C Serum ; Sanítas Skincare ) during microneedle therapy.
Two patients participated in histological evaluations.
Two patients ( @percent@ ) died in hospital without discharge.
Two patients ( @percent@ ) had catheter misplacements , recognized by intraoperative IF.
Two patients ( @percent@ ) had good outcomes with mild tendon irritation and stiffness not requiring further intervention.
Two patients presented with dehiscence of the scar , and one patient experienced punctual retroauricular skin necrosis , which healed uneventfully with conservative treatment.
Two patients reported that the knot in the temporal region was palpable through the skin.
Two patients required tracheostomy for long-term ventilator support.
Two patients underwent bilateral procedures , yielding a total of @number@ cases in Group I. TJR was performed on @number@ patients in Group II.
Two patients underwent successful cochlear implantation , achieving open-set speech recognition.
Two patients were able to walk with one crunch.
Two patients were treated with internal fixator removal.
Two patients with an initially occluded bypass and one with a secondary bypass occlusion suffered from new neurological symptoms.
Two patients with NRAS and HRAS mutations showed a partial and complete response to cetuximab , respectively.
Two PCs explained @percent@ of the waveform variance.
Two-photon polymerization ( 2PP ) is applied for the fabrication of 3-D Zr-Si scaffolds for bone tissue engineering.
Two pilot studies were run to assess the effect of daily oral supplementation with @number@ mg Ovoderm on skin parameters.
Two-point discrimination deteriorated with age ( p = @number@ ) , but with no interaction between sex , handedness , or changes in skin mechanics.
Two polyphenol extracts derived from roots of Cervical cancer is a serious public-health problem in Asian countries.
Two population-based studies key to advancing knowledge of brain aging are the Honolulu-Asia Aging Study ( HAAS ) and the Nun Study.
Two Power Plate® platforms were attached back to back using a Theraband®.
Two predominant factors-namely space radiation and microgravity-have a crucial impact on oxidative stress in living organisms.
Two previously published linear models were applied to the subjects of the French database and compared with BN predictions.
Two principles should be kept in mind when performing preoperative evaluation of the elderly patient.
Two product assessment studies are also presented here , demonstrating the ability of anti-ageing products to deliver on objective and subjective improvements in skin brightness.
Two programs were identified as possessing Level I evidence , three programs demonstrated Level II evidence and an additional two programs demonstrated Level III evidence.
Two proposed disease-modifying therapies , chondroitin sulfate and hydroxychloroquine , have had unclear effects on disease modification in clinical trials.
Two proteins with altered abundance were confirmed using Western blot analysis.
Two PRX-treated adolescents died unexpectedly after the FST suggesting a compromised response to physical stress.
Two PSEN1 mutations ( p.R352C and p.M233L ) were identified in @number@ EOFAD families , respectively.
Two questions run through her work and remain of central importance today.
Two random-dot patterns were presented sequentially on a black screen , separated by a blank inter-stimulus interval ranging from @number@ s to @number@ s.
Two recent discoveries illustrate this particularly well.
Two recent studies identify how sex-specific pheromonal factors in flies and worms alter lifespan through metabolic pathways that are shared with mammals.
Two regions were studied from each brain : association cortex in the planum temporale ( BA22 ) and primary auditory cortex ( BA41 ) .
Two representative cases demonstrate that the personalized recommendations could contribute to more prompt and accurate responses to ADEs.
Two researchers independently reviewed search results.
Two researchers independently screened papers and extracted data.
Two researchers manually coded @number@ random tweets on @number@ dimensions.
Two researchers screened the titles and abstracts of all @number@ retrieved studies and then full-text versions of @number@ retained studies.
Two resin cements , namely , Variolink II and Multilink Automix were adhered onto the zirconia surfaces with their corresponding adhesive systems.
Two resin cements were used for cementation of crowns : Clearfil SA Cement ( CSA ) and Variolink II ( VAR ) .
Two results were found.
Two review articles published in @number@ and @number@ by Hanahan and Weinberg have dominated the discourse about carcinogenesis among researchers in the recent past.
Two review authors independently selected the eligible studies and extracted data on participants ' characteristics and rates of chronic musculoskeletal disorders.
Two reviewers appraised the quality of the data extracted.
Two reviewers assessed the quality of the evidence.
Two reviewers evaluated each manuscript.
Two reviewers extracted data.
Two reviewers independently assessed interventional studies for potential inclusion.
Two reviewers independently determined study eligibility.
Two reviewers independently determined the eligibility of studies and assessed the reporting quality of included randomized controlled trials ( RCTs ) .
Two reviewers independently evaluated studies for eligibility , critically appraised the included studies , and extracted data into standardized evidence tables.
Two reviewers independently screened and selected prospective cohorts providing baseline thyroid status and serial bone mineral density ( BMD ) measurements.
Two reviewers independently screened articles and abstracts using inclusion and exclusion criteria.
Two reviewers performed screening and data abstraction.
Two reviewers reviewed abstracts and abstracted data using standardized forms.
Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail / pre-frail vs. robust.
Two reviewers separately verified the inclusion criteria of relevant studies for the objective of the review.
Two reviewers thematically analyzed the interview data.
Two reviewers will independently assess each study for inclusion and disagreements will be resolved by a third reviewer.
Two reviewers will independently screen references identified by the literature search , as well as potentially relevant full-text articles.
Two reviewers will independently screen the search results , extract data , and assess risk of bias.
Two samples of infants are included : those at low- and high-risk for ASD.
Two samples of the police force from one of the states of the Federal Republic of Germany were used.
Two samples were elicited for each modality , @number@ describing recent events and @number@ describing childhood memories.
Two samples were recruited through child health centers in Northern Finland.
Two-samplet test or Wilcoxon rank sum tests were used for continuous variables and exact chi-square tests were used for comparison between groups.
Two-sample t-tests were used in the analysis of OCT-derived optic nerve head measures between healthy controls and MS patients.
Two scenarios entail mostly positive aspects but one of them has a tendency towards , a \ "health control \ " state.
Two segments of a retinal artery were measured simultaneously.
Two self-rating scales ( Zung Self-rating Depression Scale and 15-item Geriatric Depression Scale ) were also used.
Two separate nested case-control analyses estimated the risk of first-time chronic and paroxysmal AF among users of SAIDs and NSAIDs.
Two servings were taken every day during the @number@ weeks that preceded or followed a period of @number@ weeks without soft plain cheese consumption.
Two sets of regression models analyzed categorical ER use and repeat ER use.
Two siblings of one patient also carried the p.A152T variant , and both have progressive cognitive impairment.
Two siblings presented with Evans syndrome , viral infections , and progressive leukopenia.
Two simple questions ( one for parents of newborns , one for older patients ) can improve hearing loss identification.
Two single nucleotide polymorphisms ( SNPs ) on chromosome 12p12 were the initial foci of our study : rs704180 and rs73069071.
Two sleep quality indices were generated through factor analyses.
Two small trials reported no difference in urinary symptom scores between finasteride and tamsulosin.
Two SNPs from SLC6A4 ( rs25533 and rs1042173 ) and age were the only variables associated with physical resilience and explained @percent@ of the variance.
Two social variables-community integration and entitlements-predicted remission on follow-up , thus suggesting social interventions may be especially useful strategies for this population.
Two sources presented statements ( half typical for a young adult , half for an old adult ) .
Two specialist geriatricians assessed individuals sequentially referred for an acute care geriatric consultation.
Two specific AGEs involved in aging , pentosidine and Nε-Carboxymethyl lysine , were significantly increased in IPF samples.
Two specific predictions follow from these neuroanatomical arrangements-namely , that olfaction would be associated with value-based decision making and with emotional memory.
Two stable human iPSC lines were established from primary human dermal fibroblasts of two healthy volunteers.
Two-stage probit and least squares regression models assessed the impact of relocation on familial and nonfamilial emotional , instrumental , and financial support.
Two-stage probit least squares models assess the impact of relocation on depression and whether social support influences this relationship.
Two-step indirect immunohistochemistry was performed , and images were examined using laser confocal microscopy.
Two stepwise regressions were used to find MGS predictors in two models : physical abilities and global.
Two studies are presented in this regard in which the key intervention is a DHA supplement.
Two studies are reported representing the first use of mobile eye tracking to study emotion regulation across adulthood.
Two studies documented median survival worse in patients over age @number@ with dementia and PEG placement.
Two studies examined the ability of the life script account to explain the reminiscence bump for emotionally charged autobiographical memories among Malaysian participants.
Two studies found that incobotulinumtoxinA was noninferior or equivalent to onabotulinumtoxinA for the treatment of glabellar frown lines ( GFLs ) .
Two studies have demonstrated that ASC incurs lower inpatient costs than LSC or RSC ( grade C ) .
Two studies showed increasing serum 25-OHD levels.
Two studies took into account only one kind of independent variables.
Two studies were completed.
Two studies were rated as high-quality studies , and three were rated as fair quality.
Two subgroups were defined according to their degrees of loneliness.
Two subjects discontinued : @number@ serious AE unrelated to treatment ( myocardial infarction ) and @number@ treatment-related AE ( injection site pain ) .
Two subjects reported history of sleep-related injury.
Two successive cleavages are necessary to free the Abeta peptide from the amyloid precursor protein ( APP ) .
Two such instruments are Five Wishes and Physician Order for Life-Sustaining Treatment.
Two such programs have been successfully introduced in New Zealand : the home-based Otago Exercise Programme and tai chi classes.
Two such programs , the naturally occurring retirement community ( NORC ) model and the Village model , seem to have had the most success.
Two superordinate themes , Age and Brain , emerged from prior analyses and are investigated in the present article.
Two surrogate peptides per protein were selected for the quantification of CES1 and CES2 protein abundance.
Two tablets of a micronutrient supplement ( Perfectil® Platinum ) or placebo were administered once daily for @number@ months.
Two thematic categories emerged from the analysis : nursing consultation for the elderly performed at ESF and professional qualification in health care for the elderly.
Two themes were present across the five points in time-safety and usefulness.
Two theories of cognitive aging , attentional capacity models and inhibitory deficit models , make opposite predictions about age differences in susceptibility to inattentional blindness.
Two-thirds , however , seemed satisfied with the results.
Two-thirds of patients with critical limb ischemia present with trophic disorders.
Two thirds of patients with PD were not able to walk unassisted at discharge.
Two thirds of the patients had adrenal hyperandrogenism , and estradiol and insulin did not influence adrenal secretion.
Two thousand five hundred and twenty-four adults in Araihazar , Bangladesh , drew an Archimedes spiral with each hand.
Two thousand three hundred thirty-seven individuals over @number@ underwent screening , clinical confirmation and 1-year follow-up.
Two thousand three hundred twenty-nine participants completed the survey for a response rate of @percent@ and a margin of error of @percent@.
Two time periods were defined : 1989-2001 ( early period ) and 2000-2012 ( late period ) .
Two to five experts validated the content of each DB.
Two topical onychomycosis treatments , efinaconazole @percent@ solution , and tavaborole @percent@ solution were recently approved by the FDA.
Two traits : agreeableness and conscientiousness increase significantly.
Two treatments were performed @number@ weeks apart using a stamp method with 0-20% overlap.
Two trials which included a personalised music intervention reported no significant differences between simulated presence and music on behavioural outcomes.
Two types of adenosine receptors seem to be relevant to the sleep function , A1 and A2A.
Two types of control groups were used : non-demented and highly functioning non-demented.
Two types of the adjustment were established : gradual ( @number@ patients ) and accelerated ( @number@ patients ) .
Two ubiquitous features of the aging brain are the intracellular accumulation of aggregated proteins and inflammation.
Two validated clinical tools were used to determine HRQoL and symptom burden.
Two variants were genotyped in a cohort of well-studied adult TBMN patients from @number@ Greek-Cypriot families , with a homogeneous genetic background.
Two variants were newly identified in @number@ individual FALS cases.
Two vascular neurologists reviewed MRIs , and potential CCMs were classified using Zabramski classification.
Two waves of each data set were analyzed.
Two waves of neurocognitive assessments occurred during follow-up.
Two-wave status stability groups included sustained normal aging , transitional early impairment , and chronic impairment.
Two-way analyses of variance were performed with MTA and PA as independent variables , and cognitive domains as dependent variables.
Two-way analysis of variance ( ANOVA ) analysis with multiple comparisons test was applied for statistical analysis.
Two-way ANOVA and Tukey S post hoc tests were used to analyze the data ( alpha = @number@ ) .
Two-way ANOVA showed no difference in μTBS between young and old dentin.
Two-way ANOVA , with age and culture as grouping factors , was applied for statistical analysis ( p < @number@ ) .
Two-way repeated-measures ANOVAs revealed significant main effects of walking conditions.
Two-way repeated measures ANOVAs were used for statistical analysis.
Two week recovery time was allowed between successive dives.
Two weeks after performing vitrectomy in the right eye , vitrectomy was performed in the left eye.
Two weeks later , she found out that she was pregnant.
Two weeks later the participants retrieved the same set of events from their lives and reported how old they were when those events occurred.
Two were studies on vascular dementia , and the other was on Alzheimer's dementia.
Two with persistent and permanent atrial fibrillation spontaneously reverted to sinus rhythm during follow-up.
Two women , @number@ % , and @number@ men , @number@ % , terminated head-up tilt test due to vasovagal syncope or presyncopal symptoms.
Two-year event-free survival ( EFS ) and overall survival ( OS ) were @number@ and @percent@ , respectively.
Two years and @number@ months after surgery , no recurrence has been observed in the patient.
Two-year total medical care spending was estimated by using generalized linear models with gamma distribution and log link-including endogeneity-corrected models.
TxB2 increased in the RAL versus PI / NNRTI arm ( @number@ versus @number@ P = @number@ ) .
TXB2 levels were correlated with VEGF.
Tx-HTN had higher rates of low education , depression , low physical activity , chronic heart failure , ischemic heart disease , chronic kidney disease.
TXS and VEGF expression levels were higher in adenocarcinoma ( p < 0.0001 ) and female patients ( p < 0.05 ) .
TXS and VEGF were expressed to a varying degree in NSCLC tissue.
TXS expression was correlated with VEGF and CD-31.
TXS has been identified as a potential therapeutic target in NSCLC.
TXS over-expression has been reported in a range of cancers , and associated with angiogenesis and poor outcome.
TXS overexpression was also associated with higher levels of VEGF , microvessel density , and reduced apoptosis in xenograft tumors.
TXS was associated with VEGF ( p < 0.0001 ) and microvessel density ( CD-31 ; p < 0.05 ) .
Type-1 interferons are pleiotropic cytokines involved in the initiation and regulation of the pro-inflammatory response ; however , their role in AD is unknown.
Type A FLS Models are most successful in initiating diagnostic and treatment plans for fragility fracture patients.
Type C implant presented surface micro cracks of @number@ µm at @number@ hours.
Type @date@ fibers have similar lipid content than IIA.
Type D collapse involved facet dislocation at multiple levels leading to \ "buckling collapse \ ".
Type I and IV collagens were studied by immunoblot , and activities of matrix metalloproteinase ( MMP ) @number@ and @number@ were assessed by zymography.
Type I and type III procollagen proteins were measured by Western blotting while the activities of MMPs were quantified by fluorometric Sensolyte MMP Kit.
Type I collagen degradation correlated with MMP-3 tissue levels ( rs = 0.68 , p < 0.05 ) and was attenuated with selective MMP-3 inhibitor.
Type I collagen formation was down-regulated in cultured compared with native skin explants but was not reduced further by TNF-α.
Type I collagen is the most abundant protein in skin and constitutes the majority of skin connective tissue ( dermis ) .
Type I collagen , matrix metalloproteinase-1 ( MMP-1 ) and senescence-associated β-galactosidase ( SA-β-GAL ) mRNA expression were measured by quantitative polymerase chain reaction.
Type I elongation was more common than other types of elongation.
Type IIA fibres were affected most profoundly while type I fibres were affected most weakly.
Type I , IIA and IIX muscle fibres were typed using myosin heavy chain identification.
Type I procollagen synthesis by wrinkled-skin fibroblasts was augmented by the extract.
Type @number@ diabetes and acute coronary syndromes ( ACS ) are widely interconnected.
Type @number@ diabetes is a global epidemic , and the prevalence and incidence of type @number@ diabetes are increasing.
Type @number@ diabetes is a metabolic disease that profoundly affects energy homeostasis.
Type @number@ diabetes is characterised by an age-related decline in insulin secretion.
Type @number@ Diabetes is closely associated with our daily diets and has become a global health problem with an increasing number of patients.
Type @number@ diabetes is hallmarked by insulin resistance and insufficient β-cell function.
Type @number@ diabetes mellitus and the antecedent metabolic syndrome represent the vast majority of the disease burden-increasingly prevalent in children and older adults.
Type @number@ diabetes mellitus ( DM ) appears to be a significant risk factor for Alzheimer disease ( AD ) .
Type @number@ diabetes mellitus ( DM ) is known to be closely associated with lifestyle and obesity and has a prevalence that increases with age.
Type @number@ diabetes mellitus is characterised by persistent thromboxane ( TX ) -dependent platelet activation , regardless of disease duration.
Type @number@ diabetes mellitus is characterized by hyperglycemia , insulin resistance , and relative impairment in insulin secretion and its possible long term complications.
Type @number@ diabetes mellitus is very prevalent among persons aged 60-80 years old.
Type @number@ diabetes mellitus ( T1DM ) is a major subtype of diabetes and is usually diagnosed at a young age with insulin deficiency.
Type @number@ diabetes mellitus ( T2D ) and Alzheimer disease ( AD ) are major public health burdens associated with aging.
Type @number@ diabetes mellitus ( T2D ) and Alzheimer's disease ( AD ) are two of the most common diseases of aging around the world.
Type @number@ diabetes mellitus ( T2DM ) is a major cardiovascular risk factor.
Type @number@ diabetes mellitus ( T2DM ) is associated with an increased risk of macrovascular disease.
Type @number@ diabetes predicts accelerated cognitive decline and brain atrophy.
Type @number@ diabetes ( T2D ) affects Latinos at twice the rate seen in populations of European descent.
Type @number@ diabetes ( T2D ) and Alzheimer's disease ( AD ) are complex diseases commonly associated with aging.
Type @number@ diabetes ( T2D ) is a disease of aging with indirect but detectable and cumulative neurological implications.
Type @number@ diabetes ( T2D ) is a major risk factor for late-onset Alzheimer's disease ( AD ) .
Type @number@ diabetes ( T2D ) is more prevalent among African-American ( AA ) than European-American ( EA ) women for reasons that are unknown.
Type @number@ diabetes was ascertained in @number@ individuals ( @percent@ ) .
Type @number@ diabetes was determined as having a history of diabetes , using glucose-modifying medication or fasting glucose of > 7.0 mmol / l.
Type @number@ is characterized by both NCI and DN with variable NII.
Type @number@ is characterized by numerous NCI in the cortices , associated with the involvement of lower motor neurons.
Type of operation was not predictive of mortality or major complication rate.
Type of repair ( EVAR or OR ) and perioperative and midterm outcomes were analyzed.
TYPE OF STUDY / LEVEL OF EVIDENCE : Prognostic II.
TYPE OF STUDY / LEVEL OF EVIDENCE : Prognostic III.
Types and amounts of SOC talk were quantified , and talk was narratively analyzed.
Types of interventions used were highly varied.
Types of surgical retreatment included autologous fascial sling ( @number@ ) , synthetic sling ( @number@ ) , and bulking agent ( @number@ ) .
Type XVII collagen ( COL17 ) is a transmembrane protein located at the epidermal basement membrane zone.
Typical adolescent behaviour such as increased risk-taking and novelty-seeking is probably related to developmental changes in the brain reward system.
Typical aging is associated with diminished episodic memory performance.
Typical explanations of this effect suggest the CSE is due to changes in levels of control across adjacent trials.
Typical features of cell immunosenescence are characteristics of pathologies in which the aberrant expression of NKG2D in CD4 + T cells has been described.
Typical irritants affecting aged individuals are explained and compared with irritants that seem to be more significant in younger people.
Typically , cataract is acquired with aging as a complex disorder involving environmental and genetic risk factors.
Typically , imperfections are treated with volume-correcting fillers.
Typically , patients present with failure to thrive , acanthocytosis , pigmented retinopathy and neurological features.
Typically , PRES is reversible and presents with a good outcome ; however , fatal outcomes have been reported.
Typically , such an event influences the structure and the native function of a cell or an organelle.
Typically , the test requires setting flicker thresholds for a centrally and peripherally viewed blue / green alternating target.
Typically , they become racemized , truncated , and covalently cross-linked.
Typically , this approach uses fairly high delivered energies in order to create ' microscopic wounds ' of tissue coagulation at various dermal depths.
Typically , this occurs in joint cartilages , leading to an early onset , rapidly progressing osteoarthropathy.
Typically three subgroups are observed , in which people either increase , decrease , or maintain their scores over time.
Typically , women slightly more often than men reported some kind of consequences due to spinal pain.
Typical neuropathologic lesions are represented by the amyloid plaques , neurofibrilar tangles and synapses and neurons losses.
Typical of mandibuloacral dysplasia type A is also bone resorption at defined districts including terminal phalanges , mandible and clavicles.
Typical risk factors for falls include a history of falling , decreased walking ability , and taking certain drugs.
Typical stress-and-illness models are untenable and should be replaced with life span trajectory approaches.
Typical treatments were carried out with two passes.
Typology indicators related to social integration and negative interactions with family , friendship , and church networks were used.
Tyrosine hydroxylase immunostaining demonstrated sympathetic fibers , located mainly in the tunica adventitia and the adventitia-media border.
Tyrosine @number@ phosphorylation diminishes during the normal aging process in both humans and flies.
TβRII ectopic expression in passaged chondrocytes permitted to increase the expression of several matrix genes , such as aggrecan or type II collagen.
UAB is observed in both men and women.
UACR was associated with poorer processing speed and working memory.
UA may have a protective role against AD ; however this role needs further investigations.
UBB ( @number@ ) is a mutant ubiquitin which accumulates in the hallmarks of tauopathies , including Alzheimer's disease.
Ubiquitination controls many critical cellular processes , most of which require specific lysines on ubiquitin ( Ub ) .
Ubiquitination occurs in SIRT1 protein after the phosphorylation.
Ubiquitination ofendogenous proteins is one of the key regulatory steps that guides protein degradation through regulation of proteasome activity.
Ubiquitin is a post-translational modifier with proteolytic and non-proteolytic roles in many biological processes.
Ubiquitin is essential for mitochondrial fusion , regulates mitochondria-ER contacts , and participates in maternal mtDNA inheritance.
UcOC decreases in response to vitamin K supplementation.
UC treatment without anti-CMV therapy may be warranted , particularly in patients with low-load CMV-DNA.
UDCA treatment would be an alternative prior to surgical treatment for liraglutide-related cholelithiasis.
UD radius BMD , @date@ radius BMD and total radius BMD values were significantly different among the three groups ( P < @number@ ) .
UEF score ( @number@ to @number@ ) was developed using similar UEF parameters.
UF was associated with higher use of psychotropic drugs than AF.
Ugly facial scars were recorded in @number@ patients ( @percent@ ) .
UGT activity developed age dependently in pediatric liver.
( UGTs ) are critical for the metabolism and clearance of drugs , chemicals , and hormones.
UgU induced Ca Autophagy allows cells fundamental adaptations to metabolic needs and to stress.
UHRF1-deficient cells display increased sensitivity to a variety of DNA damages.
UHRF1 interacts physically with both ERCC1 and MUS81 , two nucleases involved in the repair of ICL lesions.
UHRF1 is recruited to DNA lesions in vivo and binds directly to ICL-containing DNA.
UHR performance was significantly associated with dynamic balance capability as measured by medial-lateral inclination angle during gait.
UHS is characterized by dry , frizzy , spangly , and often fair hair that is resistant to being combed flat.
UI also affects quality of life and activities of daily living.
UI and cancer diagnoses have been associated with decreases in HRQOL.
UI is abnormal at any age.
UI is one of the most common urologic conditions but is poorly understood elderly persons.
UI is prevalent in the general population and can be both an indicator of cancer and a side effect of cancer treatment.
UI was @percent@.
UK population density has increased steadily and is the fourth highest in the EU.
Ulcerative colitis ( UC ) is a chronic inflammatory bowel disease with continuous or recurrent symptoms.
Ulcer healing rates and measurements of ulcer area were determined monthly for @number@ months.
Ulrichs's pioneering and shifting comments on age eventually fed into his legal model of consenting adults in private.
Ultimately , economic analyses may reveal reinforcement interventions to be cost-effective , especially in high-risk populations of older adults.
Ultimately , further analysis into both aspects is necessary if any progress is to be made.
Ultimately , incorporation of physiologic age can improve estimates of nondisease life expectancy , prognostic survival after HCT , and inform HCT candidacy.
Ultimately , @number@ patients were diagnosed with PD , who comprised the PD group.
Ultimately , such work could help reduce the pace of biological aging and improve health and wellness.
Ultimately , the functional changes within the brain can cause age-related disease.
Ultimately , the program authorizes a narrative of universal personhood that harmonizes with the museum's longstanding focus on temporal and aesthetic modernism.
Ultimately , these changes could have the potential to alter the physiopathology of CRS in the elderly.
Ultimately , these studies may lead to a large-animal model for telomere regulation and aging.
Ultimately , they attempt to draw neuroscience and practice closer together by using translational reasoning to suggest possible new avenues for treating these disorders.
Ultimately , this might lead to a more accurate account for the mixed pattern of impaired and preserved selective attention found in advancing age.
Ultimately , this review adds further weight to arguments to refocus dementia care on relationships in addition to individuals.
Ultimately , this yielded complete phenotypic data on @number@ individuals.
Ultimately , we propose a new hypothesis for future research designed to understand the role of FTO in setting gene expression in metabolically active tissues.
Ultrabrief pulse width stimulus could be considered for patients treated with unilateral electrode placement who experience SMW.
Ultrafine particles were evaluated under breathing conditions ranging from sedentary to heavy activities.
Ultra pure water samples aspirated into blood sampling vacuum tubes were analyzed to detect possible metal contamination.
Ultrasonic cleaning after Rocatec treatment caused a reduction in shear bond strength , but the difference was not statistically significant.
Ultrasonographic cross-sectional area ranged from @number@ to @number@ mm².
Ultrasonography and optical coherence tomography revealed the indentation of the posterior scleral profile due to the buckle.
Ultrasonography is a low-cost , easily accessible , and safe method suitable for the assessment of EI as an index of muscle quality.
Ultrasonography suggested age-related changes in muscle structure contributed to altered contractile properties in the OD.
Ultrasonography was used during the follow-up period to detect endometrioma recurrence.
Ultrasonography was used to measure ventricular volumes and other indices of cardiac performance.
Ultrasound can reliably track loss of muscle size , but also quantifies the arrangement of the muscle fascicles , known as the muscle architecture.
Ultrasound coagulation is confined to arrays of 1-mm ( @number@ ) zones that include the superficial musculoaponeurotic system and connective tissue.
Ultrasound has the unique advantage of direct visualization of treated structures during treatment.
Ultrasound is a safe and efficacious treatment for mild skin tightening and lifting.
Ultrasound longitudinal and transverse scans were performed bilaterally along the full length of Achilles tendon from the musculotendinous junction to the insertion.
Ultrasound may be used to visualize these fillers and their surrounding tissue to broaden knowledge.
Ultrasound measurements evaluated skin thickness and subepidermal low echogenic band thickness ( SLEB ) , the portion of the papillary dermis filled with solar elastosis.
Ultrasound measurements in the periorbital area showed an average improvement of @percent@ in dermal thickness suggesting significant dermal remodeling.
Ultrasound skin tightening is a noninvasive , nonablative method that allows for energy deposition into the deep dermal and subcutaneous tissue while avoiding epidermal heating.
Ultrasound ( US ) -guided compression was the treatment of choice.
Ultrasound ( US ) offers a greater accuracy in TV measurement than Prader orchidometer ( PO ) .
Ultrasound was performed before the intubation procedure ; the intubating anesthesiologists were blinded to the results of the ultrasound measurement.
Ultrasound was used to obtain both transverse and longitudinal views of each enthesis.
Ultrastructural analyses revealed an accumulation of lipofuscin granules associated with iron deposits , particularly enriched in the cerebellum and striatum of our transgenic mice.
Ultrastructural analysis of basement membrane showed typical features of aged skin such as duplication of lamina densa and alterations of hemidesmosomes.
Ultrastructural analysis of microvessels in nontransplant stroke rats revealed typical BBB pathology.
Ultrastructural examination confirmed the enlarged presynaptic profiles and also revealed variable increases in the size of synaptic vesicles , with a resulting loss of uniformity.
Ultraviolet B ( UVB ) radiation induces photoageing by upregulating the expression of matrix metalloproteinases ( MMPs ) in human skin cells.
Ultraviolet light in the 290- to 320-nm wavelength range ( UVB ) induces angiogenesis and lymphatic dysfunction in skin.
Ultraviolet radiation exposure induces DNA damage and photoaging in all skin types , including people of color.
Ultraviolet radiation ( UVR ) in sunlight has deleterious effects on skin , while behavioural changes have resulted in people gaining more sun exposure.
Ultraviolet radiation ( UVR ) is the major etiologic agent in the development of skin cancers.
Uma análise multivariável identificou os fatores de risco para polifarmácia.
Uma Jeunesse® and Juvéderm® Ultra @number@ were injected in a split-face study on @number@ healthy volunteers , whose ages ranged from 33-58 years.
UMIN000024544 and No.
UMIN000024912.
Unaccustomed exercise leads to satellite cell proliferation and increased skeletal muscle protein turnover.
Unaddressed nonmedical needs often result in poorer health and increased healthcare costs.
Unadjusted and adjusted logistic regression models were constructed.
Unadjusted and adjusted multiple logistic regression showed that none of the BMI groups had a function of decreasing the risk for poor quality.
Unadjusted and adjusted multiple logistic regressions showed that odds ratios for hyperuricemia were associated with BMI according to quartile of BMI.
Unadjusted and adjusted regression models were used to quantify associations between OHRQoL and LSM.
Unadjusted ( bivariate analysis ) and adjusted odds ratio ( OR ) and 95%CI were estimated by using backward stepwise logistic regression.
Unadjusted correlations and correlations adjusting absolute PLFA concentrations for total cholesterol were calculated.
Unaffected siblings exhibit anxiety and motor tics.
UnaG is a green-emitting fluorescent protein that utilizes unconjugated bilirubin ( BR ) as its fluorophore.
Unaided SRTn scores obtained with the same transducer ( headphones or loudspeakers ) at both test moments were included.
Unanticipated overflows may affect patients ' health and staff morale.
Unbeknownst to participants , the first cue predicted one of four targets on @percent@ of the trials.
Unbiased genome-wide association studies combined with animal models suggest that damage to the alveolar epithelium is the initiating factor in pulmonary fibrosis.
Unbleached specimens at the above mentioned irradiation times were used as controls.
Unbound drug is the pharmacodynamically relevant concentration.
Uncapping these proteins from chromosome ends leads to dramatic telomere loss and telomere dysfunction which is more abrupt than those induced by telomerase inactivation.
Uncertainties regarding model input parameters were incorporated via simple and probabilistic sensitivity analysis based on Monte Carlo simulation.
Uncertainties remain about the management of RA in the elderly as there have been few studies in this population.
Uncertainty appears to typify the experience of living with dementia.
Uncertainty remains in terms of volume gains / losses or shape fluctuations over time.
Uncertainty was accounted for by sensitivity analysis.
Unchecked chronic inflammation , oxidative stress , and free-radical damage causes proportionate aging and other related diseases / disorders.
Unclassifiable ILD was common among the elderly , but for most , the radiographic pattern was inconsistent with UIP.
Uncoated PDMS microchannel networks rapidly adsorb high levels of fibrinogen in blood contacting applications.
Uncommonly it can present with psychosis.
Uncommon morphologies or unusually extensive forms of tau pathologies should raise the suspicion of a genetic background.
Uncomplicated cases can be safely treated with conservative strategies.
Unconditional adjusted and unadjusted odds ratios for general medical and psychiatric characteristics were calculated and were the primary study focus.
Unconditional logistic of regression model was used to calculate odds ratio ( OR ) and 95%CI.
Unconditional logistic regression analysis revealed that two SNPs in ANRIL exons , rs10965215 and rs10738605 , were significantly associated with MI risk.
Unconditional logistic regression analysis was utilized to estimate the association between these polymorphisms and the risk of cervical cancer.
Unconditional logistic regression was used to investigate associations between diet and incident and persistent anemia.
Uncontaminated sediments were collected from sites in the Midwestern United States and spiked with a range of nickel concentrations.
Uncontrolled hypertension in older adults is a common yet preventable threat to healthy aging.
Uncontrolled manifold analysis was performed to determine variance components in the M-mode space and indices of M-mode synergy stabilizing COP displacement.
Uncontrolled neuroinflammatory activity can induce cellular dysfunction and demise , and lead to a self-propagating cascade of harmful pathogenic events.
Uncorrected refraction errors were the principal cause of moderate visual impairment ( @percent@ ) .
Uncoupling Protein @number@ ( UCP3 ) gene is expressed in skeletal muscle where it regulates fatty acid metabolism , redox state , and ROS formation.
Uncoupling proteins ( UCPs ) are among the most important regulators of cellular metabolism and oxidative stress.
Uncovering impairments in ambiguity resolution may be of future use in the neuropsychological assessment of non-motor deficits in PD.
Uncovering such variants would be a big step towards understanding the functional interdependencies of different FOX members and their implications in complex pathologies.
Uncovering the overlapping community structure of complex networks remains largely unknown in human brain networks.
Uncued walking required more attention than did standing and sitting.
Underactive bladder ( UAB ) is a common cause of lower urinary tract dysfunction which has an increasing incidence with aging.
Under basal conditions , we found that miR-200c inhibited the expression of KLF4 and the SUMO-conjugating enzyme Ubc9.
Under clinical observation , the range of new products present excellent tissue integration properties. < p > < em > J Drugs Dermatol.
Under conditions of acute stress Lon is highly inducible , possibly with the oxidant acting as the signal inducer , thereby providing increased protection.
Under conditions of chronic inflammation and excess stress , increased ROS production can overwhelm the antioxidant system , resulting in mtDNA damage.
Under conditions of high stress exposure , exercise may protect older adults from an increased cortisol : DHEA ratio and flatter DHEA diurnal rhythm.
Under conditions where it was well tolerated in vivo , this FOXO4 peptide neutralized doxorubicin-induced chemotoxicity.
Under culture conditions favoring differentiation , the ciPSCs could form cell derivatives from the ectoderm , mesoderm , and endoderm.
Under current trends , increased longevity in developing countries will nearly triple the number of people who survive to age @number@ by @number@
Under different circumstances , cognitive frailty may represent a precursor of neurodegenerative processes.
Under differentiation state , Q3GA promotes NSC migration , along with increased mRNA expression of CXCR4.
Under dim red light , retinae are collected in a buffer from opened eyecups cut in halves.
Under dual-task conditions , YAs performance became more similar to that of OAs.
Under ER stress , misfolded proteins interact with BiP , resulting in the release of BiP from the sensors.
Under in vivo conditions , neovascularization by glioma cells was inhibited by hUCBSC.
Under light adaptation , most OP peaks were delayed by @number@ years of age.
Underlines the consultative function of partners with women engaged in breast reconstruction.
Under LPS-induced stress condition , LA and DHA significantly suppressed VSMC proliferation.
Underlying basic needs must be addressed to improve diabetes management in this population.
Underlying chromatin features also mark common and tissue-specific age effects reflective of poised and active chromatin states , respectively.
Underlying disease and functional debility , predispose the older adult to staphylococcal carriage and infection , specially bloodstream infection and pneumonia.
Underlying genetics may contribute to the initiating sequence for these processes but the patient's lifetime environment may influence the expression of the disease.
Underlying insomnia may confound an individual's self-assessment of their CBI , a finding that has important treatment implications in dermatology.
Underlying mechanisms causing diverticulosis include weakening of the colonic wall and / or degenerative changes in the enteric nerves.
Underlying mechanisms for these disruptive procedures are unclear.
Underlying the simple model structure is important patient-level heterogeneity in health and outcomes.
Underlying this behavior may be an imbalance between the limbic subcortical areas and the prefrontal cortex.
Under mitochondria-stress conditions , membrane-anchored L-OPA1 is proteolytically cleaved to form peripheral S-OPA1 , leading to the selection of damaged mitochondria for mitophagy.
Under neurodegenerative conditions , microglia have been largely perceived as neurotoxic cells.
Under normal physiological conditions excess iron can be sequestrated in ferritin and neuromelanin.
Under nutrient-poor conditions , inhibited mTORC1 permits localized PtdIns ( @number@ ) P production at particular membranes that contribute to autophagosome formation.
Undernutrition is associated with cognitive decline.
Undernutrition is often observed in the elderly , particularly in those subjects experiencing osteoporotic fractures , more likely as a cause than a consequence.
Undernutrition may be an important modifiable risk factor for poor clinical outcomes in older individuals.
Under observation were @number@ hypertensive patients with coronary heart disease , gout and obesity I and II degree.
Under other conditions , age-equivalence has been demonstrated for identity information.
Under oxidative stress condition , the GDF-15 was increased and this increase was significantly abrogated by MA-5.
Under pathological conditions , increasing ROS production can regulate the expression of diverse inflammatory mediators during brain injury.
Under pathological conditions , Lp may suffer alterations in concentration and composition and become aggressors for EC.
Under physiological conditions , there is a production of limited range of free radicals.
Under physiologic conditions , cells maintain redox balance through production of ROS / RNS and antioxidant molecules.
Under prescribed dosing conditions , either alone or in combination therapy , efavirenz-induced CNS disturbances are frequently reported.
Underprescribing is highly prevalent across different settings , including in the community , hospitals and nursing homes.
Underprescription of potentially useful drugs is widespread among older people and may herald several adverse outcomes.
Underprescription was more frequent than overprescription.
Under relatively favorable conditions , p53 helps to maintain intracellular homeostasis by balancing anabolic and catabolic processes and by timely elimination of reactive oxygen species.
Underreporting was adjusted and trends were analyzed on the rates of crude mortality , standardized mortality and causes of death fraction among cardiovascular diseases.
Under-reporting was more frequent in subjects with higher percentage of body fat and in females ( P < @number@ ) .
Under some conditions , age-equivalence has been demonstrated for location information.
Under specific conditions , this control disappears reactivating the immune response.
Understanding age-related changes in the immune system is crucial in order to design prophylactic and immunomodulatory strategies to reduce morbidity and mortality in the elderly.
Understanding age-related experiences with intrusive thoughts is important for identifying risk and protective factors for intrusive thought problems across the adult lifespan.
Understanding age-related network changes may provide solutions for the impact of population aging and diagnosis of neurodegenerative diseases.
Understanding age-related physiologic changes will help guide treatment to maximize outcome and prevent complications.
Understanding aging and how it affects an organism's lifespan is a fundamental problem in biology.
Understanding and expanding livability considerations will have positive implications for older adults ' well-being while aging in community settings.
Understanding a patient's risk for drug-resistant pathogens will allow the physician to choose an appropriate empiric treatment regimen to optimize clinical outcomes.
Understanding associations between circulating biomarkers and physical performance across the adult life span could aid in better describing mechanistic pathways leading to disability.
Understanding biomechanical contributors to skull deformation would provide further insight into the mechanism of head injury resulting from blunt trauma.
Understanding consciousness , the brain , its aging and pathologies , and eliminating the propensity for human aggression are urgent challenges.
Understanding correlations between aging and its effects on MSCs is of the utmost importance to explain how aging happens and unravel the underlying mechanisms.
Understanding foot position and CoM trajectories might allow for appropriate rehabilitation practices.
Understanding generational characteristics and mitigating strategies can address some common issues encountered in academic EM.
Understanding generational characteristics and mitigating strategies can help address some common issues encountered in academic EM.
Understanding how ageing , HIV and quality of life intersect is key to developing effective interventions to improve QoL.
Understanding how aging affects synapses of particular neuronal subpopulations may help explain the heterogeneity of aging-related effects.
Understanding how alcohol exposure during adolescence affects aging is a critical but understudied area.
Understanding how and when cognitive change occurs over the life span is a prerequisite for understanding normal and abnormal development and aging.
Understanding how senescent cells alter the microenvironment would be aided by the ability to induce or eliminate senescent cells at will in vivo.
Understanding how SIRT1 is regulated in vivo could therefore lead to new strategies to treat age-related diseases.
Understanding how social participation is affected among women aging with HIV can inform occupational therapy assessment and treatment.
Understanding how societal factors interact and affect the older adult can help care custodians identify and remove safety deficiencies that bring about falls.
Understanding how the mammalian neocortex creates cognition largely depends on knowledge about large-scale cortical organization.
Understanding how these changes occur is thus a major priority in biogerontology.
Understanding how these decisions , are made , factors that are considered , and contextual influences is critical for improving access and enhancing care.
Understanding how to ' Age Longer and Age Well ' is a priority for people personally , for populations globally and for government policy.
Understanding how to control the migration of GBM cells is paramount to future therapies.
Understanding how to manage patients with AD is critical as we begin to care for more elderly patients in the perioperative period.
Understanding its pathophysiology that begins with venous hemodynamic abnormalities and leads to inflammatory alterations with microcirculatory changes is critical to delivering effective curative therapy.
Understanding memory experiences and concerns is important for nursing staff members who care for AL residents.
Understanding mitochondrial physiology in the context of brain aging may help identify therapeutic targets against neurodegeneration.
Understanding of home healthcare is still insufficient not only among patients ' families but even among healthcare professionals as well.
Understanding of individual pathogenesis and introduction of preventive measurements require objective assessment , i.e. , the administration of biomarkers.
Understanding of the detailed anatomy may improve the reliability of interventional procedures.
Understanding of the mechanisms of crosstalk between the inflammatory milieu and human adult mesenchymal stem cells is an important basis for clinical efforts.
Understanding of the objectively measured physical activity ( PA ) and sedentary patterns of adults with diabetes at the population level is currently limited.
Understanding of these fractures , the management options , and associated nursing care , can help reduce morbidity rate and improve functional outcomes.
Understanding older patients ' experiences of their journeys through the health system is critical to improving service integration and quality of care.
Understanding particular symptom dimensions of depressive symptoms has implications for treatment and may lead to targeted interventions and more precise knowledge of mechanisms underlying depression.
Understanding people and their needs as deficits accumulate is an exciting challenge for clinical research on frailty and its management by geriatricians.
Understanding personal memory function in the elderly may aid in the development of a more sensitive measure of subjective memory concerns.
Understanding posterior cingulate cortex function is likely to be of clinical importance.
Understanding preferences and strategic choices among the older persons can help policy makers tailor programs more effectively and efficiently , without jeopardizing elderly well-being.
Understanding social and nutritional issues facing older adults is of utmost importance to primary care providers.
Understanding sources of cognitive disparities at different ages can inform policies and interventions.
Understanding strengths and weaknesses of currently available instruments allows informed decisions about screening in this setting.
Understanding students ' beliefs and perceptions of sex / sexuality in later life can reduce and prevent ageist myths and stereotypes.
Understanding telomerase action in vivo has important implication for both cancer and aging , but there are not robust methods for monitoring telomerase action.
Understanding telomerase action in vivo has important implication for both cancer and aging , but there are not robust methods for monitoring telomerase action.
Understanding temporal and mechanistic aspects of this process is important for improving stem cell therapy protocols.
Understanding the aging process in the lung is necessary in order to provide optimal care to our aging population.
Understanding the ATP-linked mechanism of NAMPT and the catalytic site machinery may permit the design of improved NAMPT inhibitors as more efficient drugs against cancer.
Understanding the background of these recommendations will contribute for safe cancer chemotherapy.
Understanding the basic science of the structure and biomechanics of articular cartilage can help clinicians guide their patients to appropriate activity and loading choices.
Understanding the basis of this decline is a major goal of aging research.
Understanding the biological factors determining extreme longevity and compression of morbidity might help to achieve extended healthy life span for the wider population.
Understanding the biological molecules and mechanisms that modulate aging is therefore critical for the development of health-maximizing interventions for older people.
Understanding the biology of NKR ( + ) αβT cells could lead to new avenues for age-specific intervention to improve protective immunity.
Understanding the cerebral glucose metabolism in these brain regions may enable early detection of mobility limitation.
Understanding the characteristics of caregivers can help enhance strategies that support their role in providing long-term care.
Understanding the cognitive changes associated with compromised daily living skills in elderly individuals is important for making appropriate recommendations about the capacity for independent functioning.
Understanding the complexities of socio-connective trust in caregiving relationships will assist health and social care workers to mobilize relevant resources to support informal caregivers.
Understanding the context within which testosterone is prescribed may contribute to interventions to improve prescribing.
Understanding the correlates of self-care disability in this population is critical to guide clinical care and ongoing research in Geriatrics.
Understanding the detailed responses and complex adaptive mechanisms of disc cells to various stresses might provide some clues to guide therapy for disc degeneration.
Understanding the dysfunction of telomeres under oxidative stress will greatly facilitate healthy aging and advance the treatment of aging-related diseases.
Understanding the early identification of poor math skills has therefore taken on great significance.
Understanding the effect of aging on MSCs is crucial for both autologous therapy development and allogenic donors in older subjects whom degenerative diseases typically afflict.
Understanding the exact role of hypothalamic mTOR may provide new cues for therapeutic intervention in diseases.
Understanding the factors contributing to tumor initiation , progression and evolution is of paramount significance.
Understanding the fatal conceits inherent in the very architecture of national health services can be the first step toward healing our healthcare systems.
Understanding the features of COPD in older patients is important in order to introduce effective interventions and to inform efforts for health resource allocation.
Understanding the form and variation of a normal lacrimal sac fossa is helpful for preparing for a successful osteotomy with endoscopic dacryocystorhinostomy.
Understanding the genetic basis of human longevity remains a challenge but could lead to life-extending interventions and better treatments for age-related diseases.
Understanding the genetics of neuropsychiatric disorders requires an understanding of the genetics of brain structure and function.
Understanding the health impacts associated with changes in thermal conditions requires multidisciplinary approaches.
Understanding the historical context and the foundational influence of Black scholars in this field is critical.
Understanding the history of this research sheds light on the development of all three disciplines-musicology , neurology , and psychology.
Understanding the impact of schizophrenia on biological aging will require separate evaluations in men and women.
Understanding the interplay between genetic and nongenetic components provides deep insights into disease pathogenesis and promotes personalized strategies for people healthcare.
Understanding their molecular basis may facilitate targeted interventions to disrupt the accelerated aging process and its long-term impact on overall health.
Understanding the legal standard underlying the capacity needed for a specific decision is key in making a clinical opinion relevant in legal settings.
Understanding the life worlds of those who live in or have applied to this form of housing will be instrumental in developing such strategies.
Understanding the mechanism of age-related changes in COPD may identify novel therapies for this condition.
Understanding the mechanisms governing this mind-body association may have important implications for understanding and counteracting the high incidence of stress-related disorders in today's society.
Understanding the mechanisms leading to exercise intolerance in this condition may lead to strategies to improve morbidity in both HFpEF and aging.
Understanding the mechanisms of accelerated ageing in COPD may identify novel therapeutic approaches.
Understanding the mechanisms of cocaine's effects on human astrocytes may help to reveal the involvement of glial cells in addictive behaviors.
Understanding the mechanisms of neuron death is key to preventing the neurodegeneration associated with TLE.
Understanding the mechanisms that drive stem cell aging and how to counteract them is a critical step for enhancing tissue repair and maintenance during aging.
Understanding the mechanisms that underlie the association between APOE ɛ2 , cognition and longevity may provide new targets for research on promoting life-long health.
Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric , metabolic and cardiovascular disease.
Understanding the molecular basis of ageing remains a fundamental problem in biology.
Understanding the molecular mechanisms of aging may open new strategies to deal with the various diseases accompanying high age , including cancer.
Understanding the molecular mechanisms that are involved in axonal degeneration is crucial to developing new therapies against diseases involving neuronal damage.
Understanding the molecular mechanisms underlying dysfunction of aging HSCs is an important focus of biomedical research.
Understanding the molecular regulation of macroautophagy in relation to aging may offer new avenues for the treatment of age-related diseases.
Understanding the molecular underpinnings of how PNNs are altered in normal physiology and disease will offer insights into new treatment approaches for these diseases.
Understanding the motivation of older people to use exergames may assist in the process of implementation.
Understanding the neural functional organization of swallowing in healthy elders is essential in diagnosing and treating older adults with swallowing difficulties.
Understanding the normal changes is necessary before determining the efficacy of stiffness imaging for neurological disease diagnosis and therapy monitoring.
Understanding the normative neural mechanisms that support early language acquisition is crucial to understanding and perhaps ameliorating developmental language disorders.
Understanding the optimal amount of protein intake during nutritional support is therefore fundamental to appropriate clinical care.
Understanding the pathogenesis of ICIC is essential for their successful therapy and prevention.
Understanding the patient experience with TKA broadly and in relation to patient satisfaction is a key gap in existing literature.
Understanding the physiological impact of telomerase regulation is fundamental given the therapeutic strategies that are being developed that involve telomerase modulation.
Understanding the potential clinical implications of inflammation on the PK of medications is important for understanding dose-response relationships and necessitates future research.
Understanding the potential health implications of volunteering is a critical issue in current policy debates.
Understanding the potential health influence of retirement is essential , given plans to raise the retirement age in China.
Understanding the preclinical history of these associations could inform prevention strategies for common heart-lung conditions.
Understanding the predictors of facility QOL over time can help identify facility characteristics most appropriate for targeting with policy and programmatic interventions.
Understanding the presence of the superficial and the deep forehead compartments allows one to change the signs of frontal aging.
Understanding the prevalent issues is needed to address patient needs at the end-of-life.
Understanding the relationship between known factors and spending increases over time could inform policy efforts to contain future spending growth.
Understanding the relative roles of these transporters in humans will be crucial for establishing a mechanistic basis for fructose malabsorption in gastrointestinal patients.
Understanding the role of adipose tissue in health of the brain is pivotal to a deeper understanding of dementia processes.
Understanding the role of epigenetic modifications , e.g. DNA methylation , in the process of aging requires the characterization of methylation patterns in large cohorts.
Understanding the role of health in cognition and implications for quality of life in this population will be critical as life expectancies increase.
Understanding the role of mitophagy in neural function , neurodegenerative disease , and aging represents an essential goal for future research in the autophagy field.
Understanding the role of sex will be important in designing interventions and in understanding basic aging mechanisms.
Understanding the role that SB plays on health is crucial for a successful aging.
Understanding these challenges , their antecedents , and their consequences can prepare faculty , and their institutions , to better manage late-career transitions.
Understanding these conditions and developing therapies against them will require the development of new physical models of healthy and diseased neural tissue.
Understanding these developmental changes is important as these may underlie typical adolescent behavior.
Understanding these differential associations may aid in developing strategies to reduce the effects of axis dysfunction on late-life cognitive impairment.
Understanding these factors and their variability across health conditions and types of care may inform policy efforts to contain health care spending.
Understanding these linkages may help practitioners and policy makers consider strategies to enhance quality of life.
Understanding these mechanisms has helped identify several novel therapeutic targets , and several drugs and dietary interventions are now in development to treat multimorbidity.
Understanding these outcomes may help inform the clinical care of these individuals.
Understanding these patient beliefs may impact on treatment adherence and patient outcome.
Understanding these regulatory factors may provide insight into the mechanisms that convert quiescent adult prostate cells into proliferating compartments and lead to BPH or carcinoma.
Understanding these relationships may provide novel therapeutic approaches for pathologies associated with unbalanced redox state.
Understanding the structure of ageing synapses is essential to understanding the functions of these synapses and their role in the ageing nervous system.
Understanding the subtle interactions between genes , environment and homeostatic processes is the key in finding effective ways to prevent , treat or manage disease.
Understanding the temperate relationship between these events can be of utmost importance in unraveling the molecular basis of neurodegeneration.
Understanding the underlying mechanism of MGD may lead to the development of novel therapeutic strategies to treat this disease.
Understanding the underlying mechanisms may provide new insights into novel therapeutic strategies for AD.
Understanding the unique context and circumstances for individuals and organizations will enhance adoption.
Understanding the validity of a claims-based obesity diagnosis could aid researchers in understanding the feasibility of conducting research on obesity using claims data.
Understanding this question is crucial for comprehensive and humane care of the elderly and their families.
Understanding this switch in death modes may aid in understanding age-related disorders.
Understanding trends of adherence to ART among older adults is critical , especially as the population of people living with HIV grows older.
Understanding what controls the dynamics of childhood body composition and mechanisms that delay AR could help prevent obesity.
Understanding what drives osteoclast differentiation and activity is important when studying diseases characterized by heightened bone resorption relative to formation , such as osteoporosis.
Under stimulation with lipopolysaccharide , autophagy- and aging-related molecules were differentially expressed between young and aged cells.
Under stress , mitochondrial dysfunction induces ubiquitin-dependent responses that involve mitochondrial proteome remodeling and culminate in organelle removal by mitophagy.
Under such circumstances , we established an emergency care unit for the elderly at our hospital in @date@ to provide acute healthcare of the community.
Under supine resting conditions , CBF velocity was reduced in the elderly despite the fact that they had higher arterial pressure than young subjects.
Under the auditory-attend task , participants ignored visual stimuli and responded to rare target tones.
Under the auditory-ignore ( visual-attend ) task , participants ignored auditory stimuli and responded to rare target letters under low and high load.
Under the budget limitations of social security , policies and frequent policy changes have created great uncertainty and concern for the elderly population.
Under the controlled conditions of an RCT , a favorable cost differential was observed when the patient was more than @number@ km from the provider.
Under the optimal condition , Pls was detected at femtomole levels.
Under the Quality Payment Program , CMS streamlined multiple Medicare value-based payment programs into a new Merit-based Incentive Payment System ( MIPS ) .
Under thermal stress , FCP treatment significantly altered the expression of @number@ proteins ( @number@ up-regulated & @number@ down-regulated ) .
Under the same regimen , Subjects ≥65 y had lower GMC than those who < 65 years from D7 to D365 within @number@ groups.
Under these circumstances , one would like to extrapolate PK parameters from adults or older children to neonates and infants.
Under these circumstances , one would like to predict PK parameters in this age group.
Under these conditions , balance parameters are altered in both young and elderly individuals.
Under these conditions , the incidence of replicative senescence and rates of age-correlated telomere shortening were insignificant.
Under this condition , insulin action was enhanced in myotubes from lean but not obese donors.
Under this condition , platelets are in a nonadherent \ "resting \ " state.
Under this demand change scenario , the effects of various LTC capacity response policies were studied and sensitivity analyses were performed.
Under this perspective and based on the current literature , this study supplies tools that help to stratify the patients.
Under this setting , the LC model has a superior performance in within-sample prediction that cannot be duplicated when predicting new samples.
Under this system , we can get bronchoscopic image , bronchoscopy room view , and patient's data simultaneously.
Under-treatment was defined as omission of drug therapy indicated for the treatment or prevention of @number@ established diseases or conditions known to be frequently under-treated.
Underweight adults showed a @number@.36-fold increased adjusted hazard ratio of death compared with normal-weight adults.
Underweight [ Body Mass Index < @number@ kg / m2 ] was not associated with the presence of aspiration.
Underweight , independently of the other variables , was not associated with impaired swallowing safety.
Underweight patients were @percent@ of the sample while obese patients were @percent@.
Underweight was a risk factor for higher mortality caused by infections ( HR = @number@ [ @percent@ CI = @number@ @date@ ] ) .
Under which conditions and with which resources is exposure to stressors harmful to health ?
Undesired submental fat ( SMF ) deposits lead to an unappealing submental profile associated with aging and overweight.
Undiagnosed asthma is frequent in elderly persons ( about @percent@ ) and still more commonplace in those with respiratory symptoms.
Undiagnosed illness was identified according to currently published criteria.
Undiluted subretinal fluid samples were collected during surgery and analyzed via magnetic bead-based immunoassay.
Unexpectedly , a pathologic hexanucleotide repeat expansion in C9ORF72 was identified in this patient.
Unexpectedly , bone mineral density at various skeletal sites in men is also better correlated with circulating levels of bioavailable estrogen than with testosterone.
Unexpectedly , crosslinked fibrils of collagen III , a type of collagen absent in retinal capillaries , were found specifically in small microaneurysms.
Unexpectedly , EGb selectively caused degradation of c-Jun protein.
Unexpectedly , elderly donors ( > 90 yrs ) harbor fewer mutations than predicted , likely due to a contracted blood progenitor pool.
Unexpectedly however , we were unable to detect a relation of the deltoid muscle shape with the degree of active glenohumeral abduction.
Unexpectedly , in critically ill ICU patients Akt-mTOR-S6k signaling was substantially higher compared with controls.
Unexpectedly , N1 responses reveal a shortening with increasing age particularly when compared with younger women.
Unexpectedly , one of the sensors yielded leading to a quick displacement of the corresponding digit.
Unexpectedly , one surviving pup was obtained after treatment with a histone @number@ demethylase inhibitor , GSK-J4 , or NCDM-32b.
Unexpectedly , parenting beliefs favoring sensitive parenting predicted lower observed sensitivity in grandmothers.
Unexpectedly , sperm concentration did not decline with increasing male age , even though we found that sperm concentration declined over time.
Unexpectedly , static bilateral postural balance remained unaltered following the period of intervention.
Unexpectedly , there was no compensatory increase in mRNA of distal acid / base transporters.
Unexpectedly , the sequence characteristics of hypo- and hypermethylated domains in cerebellum were distinct.
Unexpectedly , we also found that Tsc1-Tsc2 loss activated RalA / B independently of Rheb-mTOR signaling.
Unexpectedly , we demonstrate that co-expression with FBG1 increases total APC2 levels.
Unexpectedly , we find a dramatic sequence- and lamin-dependent loss of local interactions in heterochromatin.
Unexpectedly , we found that serum exosomal GGT activity was significantly higher in PC patients than in benign prostatic hyperplasia ( BPH ) patients.
Unexpectedly , we found that the expression of proto-oncogene PIM-1 , which can promote tumorigenesis , is induced at transcriptional level during senescence.
Unexpectedly , we found that the same measures peaked for the music of participants ' parents ' generation.
Unexposed patients were included to adjust for the increasing incidence of hospitalization for stroke with age.
Unfilled areas were not detected in Groups C and E of all FSs.
Unflanked trials served as the baseline condition.
Unforgiveness may have its association with self-reported physical health through its interruption of other positive traits that typically confer health benefits.
Unfortunately , actual lifestyle change strategy fail to prevent cardiovascular events for several reasons , thus specific medications are needed.
Unfortunately , advancing age is also associated with asymptomatic brain white matter injury.
Unfortunately , and despite these considerations , very few data are available on the activity and safety of metronomic chemotherapy in elderly patients.
Unfortunately , a suitable prognostic score has not been identified , yet.
Unfortunately , best practice education that focuses on the interprofessional healthcare of the elderly does not yet exist.
Unfortunately , both viability and angiogenic quality of autologous CD34 + cells decline with advanced age and diminished cardiovascular health.
Unfortunately , chronic activation of these adaptations under conditions such as low socioeconomic status ( SES ) can have negative consequences for long-term health.
Unfortunately , clinical development of drugs for the symptomatic and disease-modifying treatment of AD has resulted in both promise and disappointment.
Unfortunately , current treatments for AF are suboptimal , in large part because the molecular mechanisms underlying AF are not well understood.
Unfortunately , data on the worldwide distribution of SCs remain scarce.
Unfortunately , diagnostic measures and treatment options for alcohol dependence are rarely dedicated to adolescent and aging populations.
Unfortunately , different health care professions are rarely educated together or trained in teamwork skills.
Unfortunately , driving researchers have frequently failed to report any screening test properties.
Unfortunately , due to limited evidence based data , robust screening guidelines for post transplant cancer prevention have yet to be implemented in this population.
Unfortunately , during the daily practice we do not always take into account of the changes with aging.
Unfortunately , effective delivery is complex and time consuming , placing a high demand on already overworked bedside nurses.
Unfortunately , elderly patients ( ≥65 years ) often go untreated and they are also under-represented in clinical trials.
Unfortunately , few , if any , preemptive therapies have proven effective in preventing AKI.
Unfortunately , health personnel may misinterpret these symptoms as neuropsychiatric symptoms of dementia.
Unfortunately , however , there have been many hospitals that cannot deal with TB properly.
Unfortunately , increased longevity does not coincide with an equal increase in years spend in good health.
Unfortunately , it often goes undiagnosed because both patients and health-care providers may be reluctant to bring it up at an annual office visit.
Unfortunately , its invasion into the deeper dermis increases the risk of it spreading to the lymph nodes and distant organs.
Unfortunately , little attention has been given to personality disorders in middle adulthood and later life.
Unfortunately , little progress has been made therapeutically to avert this epidemic.
Unfortunately , low bioavailability and rapid degradation to less active metabolites limit the use of this compound in a practical medicine.
Unfortunately , many minority women are still unaware of the importance of this disease.
Unfortunately , mitochondria undergo age-associated changes that compromise the above-mentioned properties that eventually contribute to the development of sarcopenia.
Unfortunately , most of the longitudinal neuroimaging data available in the clinical settings is acquired at largely varying time intervals.
Unfortunately , new technologies can sometimes make a task more difficult , slower , dangerous , or perhaps more frustrating.
Unfortunately , no large , longitudinal studies performed in the general population have been conducted to further explore this observation.
Unfortunately , not all home healthcare agencies ( HHA ) are accredited by the Joint Commissions.
Unfortunately , paclitaxel is a P-glycoprotein substrate and has poor blood-brain barrier permeability , making it unsuitable for the treatment of human tauopathies.
Unfortunately , previous studies did not integrate both pulmonary and cardiac determinants of functional status.
Unfortunately , regenerative potential of the adult heart is limited.
Unfortunately , research for effective treatments is hampered by lack of knowledge on the pathologic processes underpinning these diseases and of reliable biomarkers.
Unfortunately , sIBM is also generally refractory to immune therapy.
Unfortunately , the authors found the former classification somewhat confusing.
Unfortunately , the efficacy of these treatments is often countered by the acquisition of drug resistance.
Unfortunately , the Government did not support these recommendations.
Unfortunately , the ideal filler has not yet been discovered and all of them may induce adverse reactions.
Unfortunately , their effectiveness is not interminable , and the effect size limited.
Unfortunately , the lack of consensus around a single operational definition has limited the clinical implementation of frailty in clinical practice.
Unfortunately , the long-term effects of different creatine application strategies on aging muscle are relatively unknown.
Unfortunately , the outcomes for joint replacement differ significantly by the joint being replaced.
Unfortunately , the rates of early failure and non-maturation are very high.
Unfortunately , there are currently no commercially-available actuators compatible with the human requirements of flexibility , quietness , lightness and a high power-to-weight ratio.
Unfortunately , there are long waiting lists in some neighbourhoods that are often due to a shortage of volunteers.
Unfortunately , there are no causative treatment options for this rare , autosomal-recessive disorder , emphasizing the importance of an early diagnosis.
Unfortunately , there are no consensus diagnostic criteria for sarcopenia.
Unfortunately , there are no known interventions that currently have such effectiveness.
Unfortunately , there are no laboratory markers present for the diagnosis of preclinical cases of AD.
Unfortunately , there is limited information about the exact incidence and prevalence of many physical late effects.
Unfortunately , there is no therapy or preventive strategy currently available.
Unfortunately , the traditional text-based screening method tends to be fairly passive.
Unfortunately , they are often wrongly considered as alternatives and / or substitutables.
Unfortunately they reflect only part of the truth and are therefore misleading.
Unfortunately , this category of aviation holds a lackluster safety record , accounting for @percent@ of civil aviation fatalities.
Unfortunately this medication is associated with a high rate of adverse effects and as a consequence non-adherence.
Unfortunately , this method has some negative effects.
Unfortunately , this significant plant species has not been assessed under improved cultivation conditions with the aim of conservation in natural habitats and high quality.
Unfortunately this still means increased years of poor health or disability.
Unfortunately , this trend will only increase given the growth of an aging population worldwide.
Unfortunately , those with the greatest need for diabetes-related care are least likely to access that care.
Unfortunately , traditional \ "explicit \ " techniques for assessing attitudes ( i.e. , self-report measures ) have serious drawbacks.
Unfortunately , treatment for established drug-induced kidney injury is limited and supportive care is required.
Unfortunately , universally accepted endpoints for the evaluation of new drugs in severe infections are lacking.
Unfortunately , very little is known about the factors that contribute to its formation in early development.
Unfortunately , we still lack appropriate tools to explore decision-making in routine practice.
Unhealthy alcohol use is common among HIV-positive patients , yet effective evidence-based treatments are rarely provided in clinical settings providing HIV care.
Unhealthy and counterproductive competition among traditional disciplines has developed in the field of vascular care.
Unhealthy older octogenarians show increased levels of several plasma proteins of inflammation and coagulation.
Uni and multivariable repeated measures regression models evaluated factors associated with neurocognitive performance.
Uni- and multivariate analyses were done to determine associated factors for frailty.
Uni- and multivariate analyses were performed to evaluate postoperative outcomes.
Uniaxial tension tests along the fiber direction were performed in physiological conditions.
UNICORT is easy to apply , as it is computationally efficient and its basic framework is implemented as part of the tissue segmentation in SPM8.
Uniform neuropathologic examination identified macroscopic infarcts and microinfarcts , blinded to clinical information.
Uniform neuropathologic examinations quantified measures of Alzheimer's disease , cerebral infarcts , Lewy body disease , and hippocampal sclerosis.
Uniform pathophysiological and pathogenetic mechanisms of these processes and their interrelation are analyzed.
Uniform quality control procedures were applied to all datasets.
Unilateral aphakia was present in @number@ people and bilateral aphakia in @number@ people.
Unilateral ureteral obstruction causes subacute renal injury characterized by tubular cell injury , interstitial inflammation and fibrosis.
Unilateral ureteral obstruction is a popular experimental model of renal injury.
Unimpaired cognition is an important feature of successful aging.
Unintentional body weight loss is common in patients with dementia and is linked to cognitive impairment and poorer disease outcomes.
Unintentional injuries are among the leading causes of death and disability in older adults.
Unintentional therapeutic errors involving insulin occurred primarily in adults > 40 years ( @percent@ ) , with @percent@ occurring in women.
Uninterrupted funding resulted in fulfillment of GACA goals ( @percent@ ) and overall career success ( @percent@ ) .
Unipedal stance time , normal @number@ MWT , and fast @number@ MWT were significantly different between the @number@ groups.
Unipolar depression is associated with dysfunctions in similar cognitive domains deficits that impact the functioning and quality of life of these patients.
Unique factors related to cognitive functioning in U.S. and Korean older adults highlight the important role of societal influences on cognitive outcomes.
Unique factors related to cognitive functioning in U.S. and Korean older adults highlight the important role of societal influences on cognitive outcomes.
Unique features of the anconeus may permit MUNEs at high muscle activation levels.
Unique findings relate to the challenges inherent in decision-making within the context of multiple chronic conditions.
Unique identifier : ISRCTN10709813.
Unique identifier : ISRCTN25337470.
Unique identifier : ISRCTN35739639.
Unique identifier : ISRCTN43596477.
Unique identifier : NCT00023595.
Unique identifier : NCT00542945.
Unique identifier : NCT00597922.
Unique identifier : NCT01014572.
Unique identifier : NCT01206062.
UNIQUE IDENTIFIER : NCT-01212978.
Unique identifier : NCT013655104.
Unique identifier : NCT01366404.
Unique identifier : NCT01410318.
Unique identifier : NCT01959971.
Unique identifier : NCT02388412.
Unique identifier : NCT02663791.
Unique in comparison with other healthy ageing concepts , resilient ageing can be applied to all older people , regardless of age or affliction.
Unique variations in the OPTN gene are rare in FALS cases and were not identified in any SALS patients , all of European descent.
Unit bone mass corresponded to a higher muscle mass in subjects with reduced bone mineral density than those normal subjects.
Unit costs were for the United Kingdom , Switzerland , and Germany.
United Nations Population Prospect data were used for population projections.
Unitization of preexperimental associations , as in CW pairs , can alleviate age-related associative deficits.
Unit prices paid for apheresis- and WB-derived PLTs increased by @number@ and @percent@ per year on average , respectively.
Units in the control arm will provide care as usual.
Univariable analyses examined the relationship between neurogranin and the other AD-related biomarkers.
Univariable and multivariable regression analyses were performed.
Univariate analyses revealed equal PMC recruitment across strategies for older adults , but greater activity during distraction than reappraisal for younger adults.
Univariate analyses were run initially , with false discovery rate = @number@ to select biomarker variables for inclusion in multivariable longitudinal mixed-effect models.
Univariate analyses were used to describe patient characteristics and physician survey responses.
Univariate analysis of variance was performed to determine significant group differences among nurses in the three hospital types.
Univariate analysis of variance was used to compare the difference between pre- and post-intervention in Tai Chi participants.
Univariate analysis of variance was used to compare the effectiveness of a home-based exercise program between individuals with and without MetS.
Univariate analysis revealed that the hyperperfusion on day @number@ had a significant relationship with functional outcome at @number@ months ( P = 0.04 ) .
Univariate analysis revealed that this difference was not significant ( P = @number@ ) .
Univariate analysis revealed tumor size , pStage , lymph node dissection , operation time or blood loss were correlated with postoperative complication.
Univariate analysis showed moderate-to-high genetic influences with heritability @number@ for cognition and @number@ for memory.
Univariate analysis showed that dyspnea was associated with 13-year mortality.
Univariate analysis showed that preoperative systemic chemotherapy and longer operative time were associated with higher morbidity in the elderly.
Univariate analysis showed that slow gait speed could predict rapid cognitive decline ( OR @number@ @percent@ CI @number@.20- @time@ , P = @number@ ) .
Univariate analysis was also performed to identify variables associated with higher surgical risk.
Univariate analysis was performed using χ ( @number@ ) , Mantel-Haenszel , ANOVA , and Kaplan-Meier log rank analyses.
Univariate analysis was used to select factors ( P < @number@ ) for entry into multivariate stepwise logistic regressions.
Univariate analysis was used to test initial presentation and BAVM characteristics in different ages.
Univariate and multiple logistic regressions were used to analyze the outcomes.
Univariate and multiple regression analyses for each marker showed that all were significantly associated with post-discharge survival.
Univariate and multivariable Cox regression models quantified associations between sociodemographic characteristics and TMD incidence.
Univariate and multivariate analyses demonstrated that PSD-95 significantly increased in aged females and SYP significantly decreased in males , but GEP was stable.
Univariate and multivariate analyses were applied to analyze risk factors of PMI.
Univariate and multivariate analyses were performed for questionnaire / easily obtainable variables , imaging variables , genetic and biochemical markers.
Univariate and multivariate analyses were performed to determine the variables associated with MMSE score.
Univariate and multivariate linear regression modelling of the associations between age and body mass index ( BMI ) and SHBG was performed.
Univariate and multivariate logistic regression analyses were carried out in order to identify the correlates of SA.
Univariate and multivariate logistic regression analyses were used.
Univariate and multivariate logistic regression analyses were used to identify independent risk factors of acute exacerbation.
Univariate and multivariate logistic regressions were used to quantify racial differences with respect to self-reported stress after adjusting for potential confounders.
Univariate and multivariate regression analyses were performed to identify factors independently related to FNBMD.
Univariate and multivariate regression analyses were performed to identify predictors of radiation dose.
Univariate and multivariate regression analyses were used to analyze possible correlates of SA.
Univariate and multivariate statistical methods were used to evaluate data.
Univariate Cox regression analyses were performed.
Univariate logistic regression analysis was performed to explore the association between medication classes and the outcome parameter ( recurrent fall ) .
Univariate logistic regressions were applied to select relevant covariates.
Univariate methods are used to present a comparative profile of return migrants.
Univariate models revealed @number@ predictors of survival.
Univariate models revealed that higher log-transformed UME levels were significantly associated with lower WBC and PLT counts ( P = @number@ and @number@ ) .
Univariate regression analysis showed that greater CT was significantly associated with smaller IAREA ( p = @number@ ) .
Univariate sensitivity analyses were performed to arrive at a plausible range of outcomes.
Univariative and multivariative analysis using Cox proportional hazard model revealed that male gender and non-adenocarcinoma histology were significant risk factors for poor prognosis.
Universal access to medical care can be considered a basic ingredient of the so-called \ "European social model. \ "
Universality of thymic involution in all species possessing thymus , including human , indicates it as a long-standing evolutionary event.
Universal sampling technique was employed , in which every household in the community was visited and all elderly persons were selected.
University hospitals treat many elderly patients and patients with poor general condition.
University students are the group of people most likely to postpone parenthood , yet several international studies have shown that they overestimate their fertility.
Unknown diffusible factors from the neural stem cells improve the survival of aged and degenerating neurons in postmortem human brain slice cultures.
UNLABELLED : A comprehensive review of literature was conducted to investigate variation in hip fracture incident rates around the world.
UNLABELLED : Adipose tissue is the largest endocrine organ , producing various adipokines and many other substances.
UNLABELLED : Advanced Glycation End products ( AGEs ) are the products of nonenzymatic glycation and oxidation of proteins and lipids.
UNLABELLED : Age related macular degeneration ( AMD ) is the most frequent cause of blindness in the elderly.
UNLABELLED : Aging alone is not the only factor accounting for poor bone health in older men.
UNLABELLED : Aging is a major risk factor for poor outcome in patients with ruptured or unruptured intracranial aneurysms ( IA ) submitted to treatment.
UNLABELLED : Aging population , increases the number of major abdominal surgery ( MAS ) performed in the elderly.
UNLABELLED : AIM.
UNLABELLED : AIMS OF INVESTIGATION : The chronological age of the Caucasian population and their anthropometrical data have significantly changed within the last five decades.
UNLABELLED : A main aim of the paper is decomposition of changes in life expectancies by age groups in the postwar Poland.
UNLABELLED : Asymptomatic mouth floor enlargements may be observed in edentulous patients.
UNLABELLED : Automated software was used to measure the mandibular cortical width in a large sample of dental radiographs.
UNLABELLED : BACKGROUNDS / OBJECTIVES : Cathepsin D plays an important part in maintaining a normal skin barrier.
UNLABELLED : BACKGROUND / STUDY CONTEXT : Aging has traditionally been related to impairments in proper name retrieval.
UNLABELLED : BACKGROUND / STUDY CONTEXT : Arousal and negative affect modulate the effect of emotion on the subjective experience of the passage of time.
UNLABELLED : BACKGROUND / STUDY CONTEXT : Cognitive abilities experience diverse age-related changes.
UNLABELLED : BACKGROUND / STUDY CONTEXT : Current evidence suggests that dysphoric mood affects the ability to recognize facial emotion.
UNLABELLED : BACKGROUND / STUDY CONTEXT : Destination memory , remembering the destination of the information that one tells , shows significant age-related decline.
UNLABELLED : BACKGROUND / STUDY CONTEXT : It has been proposed that effects of aging are more pronounced for explicit than for implicit motor learning.
UNLABELLED : BACKGROUND / STUDY CONTEXT : Mental training may potentially enhance motor performance and self-efficacy in older adults.
UNLABELLED : BACKGROUND / STUDY CONTEXT : Physical performance measures have been found to be strong predictors of adverse outcomes in aging populations.
UNLABELLED : BACKGROUND / STUDY CONTEXT : Previous research has shown an increase of subjective organization of stimuli and of recall performance across learning trials.
UNLABELLED : BACKGROUND / STUDY CONTEXT : Recent evidence indicates that older persons have difficulty mentally representing intended movements.
UNLABELLED : BACKGROUND / STUDY CONTEXT : The negative priming effect has been traditionally interpreted as the inhibitory aftereffect of distractor processing.
UNLABELLED : BACKGROUND / STUDY CONTEXT : The purpose was to determine if aging interacts with the coding of a simple spatial-temporal movement sequence.
UNLABELLED : Brain plasticity refers to the capacity of the nervous system to change its structure and ultimately its function over a lifetime.
UNLABELLED : Caffeine is a widely used nutritional supplement which has been shown to enhance both physical and cognitive performance in younger adults.
UNLABELLED : Cancer cell resistance to chemotherapy is a major concern in clinical oncology , resulting in increased tumor growth and decreased patient survival.
UNLABELLED : Cognitive decline in aging is a pressing issue associated with significant healthcare costs and deterioration in quality of life.
UNLABELLED : COURAGE in Europe was a 3-year project involving @number@ partners from four European countries and the World Health Organization.
UNLABELLED : Delirium is one of the foremost unmet medical needs in healthcare.
UNLABELLED : Demographic changes and a more active life-style in older age have contributed to an increasing public awareness of the need for lifelong vaccination.
UNLABELLED : Depression is associated with nutritional deterioration in older persons and is highly prevalent among people of low socioeconomic status ( LSES ) .
UNLABELLED : Detrusor underactivity ( DU ) is an increasingly recognised cause of lower urinary tract symptoms in both men and women.
UNLABELLED : Does cell age matter in virulence ?
UNLABELLED : Due to its antioxidant and anti-inflammatory activities , artichoke ( Cynara scolymus ) has been used as folk medicine to treat various diseases.
UNLABELLED : Due to the aging of the population is an increase in the incidence of heart failure.
UNLABELLED : Early numerical proficiency lays the foundation for acquiring quantitative skills essential in today's technological society.
UNLABELLED : Estimation of Stature by Measuring Fibula and Ulna Bone Length in @number@ Older Adults.
UNLABELLED : Few epidemiologic studies have specifically focused on very old community dwelling population with atrial fibrillation ( AF ) .
UNLABELLED : Fracture risk is increased in type @number@ diabetes mellitus ( T2DM ) .
UNLABELLED : Frozen biospecimens are crucial for translational research and contain well-preserved nucleic acids and protein.
UNLABELLED : Gait speed predicts survival in older adults ; however , gait has not been evaluated in late middle-aged ( LMA ) populations.
UNLABELLED : Genetic skin diseases caused by mutations resulting in diminished protein synthesis could benefit from local substitution of the missing protein.
UNLABELLED : Hutchinson-Gilford progeria syndrome ( HGPS ) is a rare segmental premature aging disorder that recapitulates some biological and physical aspects of physiological aging.
UNLABELLED : In aging , the bone marrow fills with fat and this may lead to higher fracture risk.
UNLABELLED : In an increasingly ageing population , the incidence of neurodegenerative disorders such as Alzheimer's disease , Parkinson's disease and Huntington's disease are rising.
UNLABELLED : Increased carotid intima-media thickness ( cIMT ) in adults may be caused by a childhood exposure to cardiovascular risk factors.
UNLABELLED : Infections with high-risk human papillomaviruses ( hrHPV ) contribute to cervical carcinoma.
UNLABELLED : Inflammation has been suggested to be involved in the pathogenesis of benign prostatic hyperplasia ( BPH ) .
UNLABELLED : It has been suggested that some patients undergoing prolonged treatment for osteoporosis with anti-resorptive agents may benefit from discontinuing treatment.
UNLABELLED : Limited data exist regarding metabolic risk factors for deaths from hepatocellular carcinoma ( HCC ) in aging individuals.
UNLABELLED : Loss of muscle strength , flexibility , and balance are strong predictors of falls in the elderly.
UNLABELLED : Major age-related diseases such as cardiovascular disease and cancer are the primary causes of morbidity and mortality in Australia and worldwide.
UNLABELLED : Mesenchymal stromal cells ( MSCs ) have been investigated as a treatment for various inflammatory diseases because of their immunomodulatory and reparative properties.
UNLABELLED : Metastatic spinal cord compression occurs in @percent@ of cancer patients in the last @number@ years of life.
UNLABELLED : NKX3.1 is a prostate-specific homeodomain protein and tumor suppressor whose expression is reduced in the earliest phases of prostatic neoplasia.
UNLABELLED : Nonablative lasers and nonlaser systems are newer systems used for skin rejuvenation , tightening , body sculpting , and scar remodeling.
UNLABELLED : Non-enzymatic formation of advanced glycation endproducts ( AGEs ) is associated with degenerative diseases.
UNLABELLED : Non-linearity is a likely phenomenon in bone metabolism , but is often ignored in pertinent epidemiological studies.
UNLABELLED : ( @number@ ) F-FP- ( + ) -DTBZ is a novel PET radiotracer targeting vesicular monoamine transporter type @number@ ( VMAT2 ) .
UNLABELLED : Obesity has become a serious global health issue affecting both adults and children.
UNLABELLED : Older people are majority users of health and social care services in the UK and internationally.
UNLABELLED : Osteoarthritis ( OA ) is a major cause of pain and disability in the US.
UNLABELLED : Osteoporosis , a skeletal disorder characterized by a reduction in bone strength , increases fracture risk.
UNLABELLED : p63 , a p53 family member , plays pivotal roles in epidermal development , aging , and tumorigenesis.
UNLABELLED : Pain among older adults is common and generally associated with high levels of functional disability.
UNLABELLED : PET is used to image active inflammatory processes by targeting the translocator protein ( TSPO ) .
UNLABELLED : Physical activity ( PA ) decreases with increasing age despite the fact that PA exerts beneficial effects on many age-related diseases and conditions.
UNLABELLED : Population aging is associated with a higher prevalence of chronic health conditions.
UNLABELLED : Prostate cancer is the second most common malignancy among men worldwide.
UNLABELLED : Regional anesthesia has increasingly expanded its role in the perioperative care of patients undergoing foot and ankle surgery.
UNLABELLED : Resistance training ( RT ) is a proven sarcopenia countermeasure with a high degree of potency.
UNLABELLED : Running has high injury rates , especially among older runners.
UNLABELLED : Sarcopenia in older people is a major health issue and its early detection could help target interventions and improve health.
UNLABELLED : Sarcopenia is an aging syndrome that can be characterized by many criteria adjusted or not by fat mass.
UNLABELLED : Several ultrasonic devices have recently been investigated for their ability to decrease areas of focal adiposity and tighten small areas of the skin.
UNLABELLED : Signaling of the receptor for advanced glycation end products ( RAGE ) has been implicated in the development of injury-elicited vascular complications.
UNLABELLED : Social engagement provides dynamic stimulation for older individuals that influences cognition.
UNLABELLED : Social networks and improved health outcomes are strongly connected , yet many elders face isolation and loneliness.
UNLABELLED : Speech understanding disorders in the elderly may be due to peripheral or central auditory dysfunctions.
UNLABELLED : Subclinical cardiac abnormalities represent predisposing factors for cardiovascular disease ( CVD ) in obese subjects.
UNLABELLED : Substantial data have accumulated over the past decade indicating that the adult brain is capable of substantial structural and functional reorganization after stroke.
UNLABELLED : Sufficient vasodilatory and vasoconstrictive reactivity of cerebral arterioles is an important prerequisite for adequate capillary perfusion.
UNLABELLED : Telomere shortening impairs liver regeneration in mice and is associated with cirrhosis formation in humans with chronic liver disease.
UNLABELLED : The age structure of human populations is exceptional among animal species.
UNLABELLED : The consequences of influenza virus infection are generally more severe in individuals over @number@ years of age ( the elderly ) .
UNLABELLED : The expression of claudin-4 , a protein involved in tight junction complexes , is widely dysregulated in epithelial malignancies.
UNLABELLED : The isolated systolic hypertension is a distinct entity concerning evolving , pathological , diagnosis and treatment particularities.
UNLABELLED : The prevalence of menometrorrhagia in fertile women is @date@ @percent@ and increases with aging.
UNLABELLED : The purpose of this study was to understand how neighbourhoods - as physical and social environments - influence community mobility.
UNLABELLED : The role of socioeconomic status in hip fracture incidence is unclear.
UNLABELLED : The trend of extended life expectancy along with a sedentary lifestyle is typical in Western cultures.
UNLABELLED : This consensus article reviews the diagnosis and treatment of osteoporosis in geriatric populations.
UNLABELLED : This paper describes the impact of ageing on an individual's ability to process drugs.
UNLABELLED : This report describes the epidemiology , economic burden and treatment of osteoporosis in Switzerland.
UNLABELLED : This study evaluated the reference range and reproducibility of the gastric emptying study with oatmeal as a function of age and sex.
UNLABELLED : This study presents quantitative ultrasonography ( QUS ) bone quality data for an underrepresented , south Asian pediatric population from Nepal.
UNLABELLED : This study tested the effects of aging and race on responses to noxious stimuli using a wide range of stimulus modalities.
UNLABELLED : Vascular dementia ( VaD ) is a leading cause of dementia in the elderly together with Alzheimer's disease with limited treatment options.
UNLABELLED : We discovered a novel somatic gene fusion , CD74-NRG1 , by transcriptome sequencing of @number@ lung adenocarcinomas of never smokers.
UNLABELLED : We studied the ability of individuals with mild cognitive impairment ( MCI ) to process emotional facial expressions ( EFEs ) .
UNLABELLED : What's known on the subject ? and What does the study add ?
UNLABELLED : What's known on the subject ? and What does the study add ?
Unless CDK is properly managed , it will not be possible to maintain quality and longevity of life.
Unless oncologist productivity can be enhanced , the anticipated shortage will strain the ability to provide quality cancer care.
Unless priced lower than enalapril ( < €0.045 per day ) , sacubitril / valsartan is very unlikely to be cost-saving / dominant.
Unlike 5ARIs , α-blockers do not impair libido.
Unlike apoptosis , mechanisms leading to necrosis are less well understood.
Unlike ATP-dependent NO liberation , the NO response to injury is insensitive to BTP-2 , which selectively blocks store-operated Ca²⁺ inflow.
Unlike BE3 , HF2-BE2 could convert C to T on both the target and non-target strand , expanding the editing scope of base editors.
Unlike CKD patients and normal controls , serum testosterone did not significantly influence TDS symptoms in RT recipients.
Unlike CLBP participants , controls showed normal , age-related increases in IL-6 levels , whereas sleep quality was unrelated to IL-6 levels.
Unlike DXA , subject-specific quantitative computed tomography-based finite element analysis ( QCT / FEA ) estimates fracture strength using 3D bone mineral distribution and geometry.
Unlike findings from memory for written prose , preserved verbal ability may not protect against developmental declines in memory for speech.
Unlike genetic effects that also play a role in cancer and aging , epigenetic aberrations can be relatively easily corrected.
Unlike health , disability can qualitatively alter the aging patterns of the LLFS participants.
Unlike in other neuroautonomic etiologies for fainting , aerobic exercise is not effective as a treatment for V-CSH , at least in the OADM population.
Unlike in the developing CNS , the complement cascade effector C3 was only present at very low levels in the adult and aging brain.
Unlike many previous studies which have found a significant relationship between gender and depressive symptoms , this study failed to reveal any such relationship.
Unlike menopause , male reproductive senescence does not involve an acute drop in fertility.
Unlike monopolar and bipolar devices , little has been studied with the unipolar hand piece.
Unlike most other cell types , neurons preferentially metabolize glucose via the pentose phosphate pathway ( PPP ) to maintain their antioxidant status.
Unlike neurons , astrocytes are resistant to Aβ cytotoxicity , which may , in part , be related to their greater reliance on glycolytic metabolism.
Unlike normal human cells that can be immortalized by enforced expression of telomerase alone , immortalization of HGPS cells requires telomerase expression and p53 repression.
Unlike nuclear cataract , progression is intermittent , stepwise and non-uniform.
Unlike older controls , most AD participants evoked similar themes when generating past and future events ( n = 23 / 30 participants ) .
Unlike other life domains , sexual quality of life ( SQoL ) has a negative relationship with age.
Unlike other midfacial techniques , the transtemporal midface achieves pull in @number@ vectors , directing the repositioning of tissuesboth superiorly and laterally.
Unlike previous descriptions of the behavioral phenotype in adults with PWS , we did not find a reduction in behavioral problems in older adults.
Unlike previous reports , we found no linear or curvilinear relationships between D1 receptor binding in DLPFC and performance in any cognitive task.
Unlike quadrupeds , human limbs are exposed to differing homeostatic challenges and uses across the life span.
Unlike replication-dependent H3. @date@ isoforms , H3.3 is expressed throughout the cell cycle and becomes enriched in postmitotic cells with age.
Unlike SAMP8 mice , pR5 mice are characterized by a robust tau pathology particularly in the amygdala and hippocampus.
Unlike structural disulfides , reversible disulfides are usually of important functional roles and may serve as redox switches.
Unlike the arterioles , CD34-immunoreactive capillaries had dimensions that were unchanged in cases with hippocampal sclerosis of ageing versus controls.
Unlike the genetic case , numerous thermodynamically accessible ' protein folding codes ' can be identified from empirical classifications.
Unlike the management of HFrEF , there is a paucity of large evidence-based trials demonstrating morbidity and mortality benefit for the treatment of HFpEF.
Unlike the murine gene , human TACI undergoes alternative messenger ( m ) RNA splicing to produce isoforms with @number@ or @number@ ligand-binding domains.
Unlike the paternal genome , the maternal genome carries a heavy footprint of parental aging.
Unlike the performance-based eight-item mouse FI , the clinical FI exhibits key features of the FI established for use in humans.
Unlike these scales , the MusEQ may be completed by either the participant or an informant.
Unlike the wet AMD , an effective therapy does not exist for dry AMD and geographic atrophy.
Unlike VAT , SAT showed some protective endocrine and inflammatory features that might explain the occurrence of obese but metabolically healthy persons.
Unlike with asthma , corticosteroid inhalers represent a third-line option for COPD.
Unlike with most species , human juvenility is extremely extended , and death is not coincident with the end of the reproductive period.
Unlike young adults , older adults exhibited illusory truth only when they lacked knowledge about claims.
Unlike younger participants , older participants accepted more often to cross and had more collisions on the small-scale simulation device than on the full-scale one.
Unmarried individuals were more likely to report abstinence , but also reported somewhat higher consumption than married individuals.
Unmet needs are prevalent among older adults with limitations across all settings and warrant further investigation and monitoring.
Unmet needs perceived by patients suffering from a severe mental illness , e.g. depression , may have a negative impact on their recovery.
Unnecessary exposure to the sun and artificial UVR ( tanning lamps ) are important personal attributable risks.
Unobserved heterogeneity in mortality risk is pervasive and consequential.
Unpaired AKU , OA and non-OA samples were compared by non-parametric Mann-Whitney U test.
Unpaired t-tests were used to identify significant differences between the two groups.
Unplanned readmissions were registered by telephone follow-up @number@ @number@ and @number@ days post-discharge.
Unprecedented advances in echocardiography , including real time three-dimensional echocardiography , facilitate a comprehensive assessment of this condition and help in the decision-making process.
Unprecedented economic challenges have resulted in significant budget downturns for all sectors , including higher education.
Unprecedented population aging in poorer settings is coinciding with the rapid spread of obesity and other chronic conditions.
Unpublished data submission was encouraged to assist in variant classification and was recognized through microattribution.
Unpublished studies were identified through the Thyroid Studies Collaboration.
Unraveling mitochondrial gene expression regulation could open new therapeutic avenues for mitochondrial diseases.
Unraveling the contribution of genetic vs. nongenetic factors to longevity is a challenging task.
Unraveling the etiology of these pathologic processes is a complex and important goal.
Unraveling these molecular mechanisms provide the rationale for the development of novel efficient therapies to combat the vascular aging process.
Unraveling these pleiotropic effects of estrogen may lead to new approaches to prevent and treat osteoporosis.
Unrecognised vision loss remains common , and screening interventions have yet to reduce its prevalence.
Unresolved questions and research gaps were identified to bring this promising natural product to the forefront of therapeutic agents for treatment of different pathologies.
Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways.
Unsatisfactory outcomes can be limited by meticulous injection technique and well thought out treatment plans.
Unscheduled homologous recombination ( HR ) can lead to genomic instability , which greatly increases the threat of neoplastic transformation in humans.
Unselected consecutive patients ( n = 7 , 487 ) admitted to the hospital over @number@ months were enrolled.
Until age @number@ most people do not have functional impairment or disability , despite the presence of chronic disorders.
Until @date@ analysis was performed on a 15-min time base , and subsequently on a 2-min time base.
Until @date@ , @percent@ of all residues of the protein have been studied by mutagenesis and / or using other approaches.
Until full comprehension of these processes is obtained , clinical applications remain remote.
Until more data become available , scheduling is likely to be determined by epidemiological and programmatic considerations in individual settings.
Until now , a direct , quantitative method for determination of the MeP adduct to BChE was unavailable.
Until now , a large majority of studies have been performed in young , otherwise healthy animals.
Until now , both simplex and familial UHS-affected case subjects with autosomal-dominant as well as -recessive inheritance have been reported.
Until now , investigation of the MPC activity has been limited.
Until now , its molecular pathogenesis has remained unknown.
Until now , limitations in the ability to enrich adult NSCs ( aNSCs ) have hampered meaningful analysis of these cells at the transcriptome level.
Until now , little is known about microglia biology in humans in part due to the lack of microglia-specific markers.
Until now , little is known about the regulatory mechanisms of microRNA expression and genes in ageing.
Until now , low vision rehabilitation does not sufficiently target concurrent impairments in vision and hearing.
Until now mobility monitoring has not been possible in routine practice.
Until now , neither legal guidelines at State level nor those of international organisations which deal with bioethical issues have concerned themselves with this matter.
Until now , only an English version of the MCQ has been psychometrically evaluated.
Until now , the interpretation of the measurement was mainly based on the individual experience of the operator , because no normative data were present.
Until now , there have been relatively few studies investigating subjective sleep quality in these individuals.
Until now , the results are discordant or are not confirmed because of methodological limitations.
Until recently , few studies had specifically evaluated the efficacy and safety of antimuscarinics in the treatment of OAB symptoms in elderly patients.
Until recently , gastric acid secretion has been believed to decrease according to age.
Until recently , however , little was known about the ' landscape ' of the human brain methylome.
Until recently , little was known about destination memory , or memory for the destination of outputted information.
Until recently , most studies on social capital and health have been cross-sectional making it difficult to draw causal conclusions.
Until recently MSA was widely conceived as a nongenetic disorder.
Until recently , programmed aging had been thought to be theoretically impossible because of the mechanics of the evolution process.
Until recently , SIRT6 was an orphan enzyme whose catalytic activity and substrates were unclear.
Until recently , studies on transformations in the intracellular redox state have been significantly hampered in living systems.
Until recently , the diminutive thickness of the cortex and its relatively low iron content have hampered in vivo study of cortical iron accumulation.
Until recently , the known functions of SIRT6 were largely restricted to the chromatin.
Until recently , the mechanisms underlying these effects were poorly understood.
Until recently , the only licensed treatments were amphotericin B ( AMB ) formulations.
Until recently , there was not a single randomized clinical study supporting this proposition.
Until recently , there was no therapy available by which the course of the disorder could be modified.
Until recently , these species have been regarded as commensals ; now they are considered as parasitic organisms.
Until recently , these variations were acknowledged as developmental variants and were not considered pathological findings.
Until recently , the terms hippocampal sclerosis of aging or hippocampal sclerosis dementia were applied in this context.
Until recently , this decline has been largely attributed to extrinsic age-related alterations in the microenvironment to which MuSCs are exposed.
Until the early 1990s , survival beyond the fourth decade for a patient with SCD was considered unusual and prompted case reports.
Until the sources of this variation are better understood , caution should be used before applying this method to estimate age in unknown skeletons.
Untreated ( ambient ) and oven-dried ( reduced microbiota ) sediment was inoculated with @percent@ sewage and artificial freshwater.
Untreated lifetime IGHD has beneficial consequences on bone status and does not have a deleterious effect on abdominal aorta calcification.
Untreated rats were used as a control ( no-treatment [ NT ] group ) .
Untreated skin was used as a control.
Untreated sleep apnea can result in significant consequences both in the short-term and long-term.
Unusual sleep postures , such as leaning forward and sitting , are observed in people with DS.
Unveiling these mechanisms will eventually identify new therapeutic targets and also improve the management of the associated complications.
Upcoming technical solutions and future directions are also addressed.
Updated diagnostic criteria have been established.
Update searches for observational studies and systematic reviews for the period @date@ to @date@ were performed on Medline and Embase.
Upon activation PARP1 utilizes key metabolites that attenuate pathways that are normally protective for the cell.
Upon admission to inpatient post-acute rehabilitation , patients completed the Pittsburgh Sleep Quality Index ( PSQI ) retrospectively regarding their sleep prior to hospitalization.
Upon admission to the hospital , this score decreased to a mean of @number@ ( SD = @number@ P = @number@ ) .
Upon any homeostatic disturbance microglia rapidly change their phenotype and contribute to processes including inflammation , tissue remodeling , and neurogenesis.
Upon arrival to the laboratory , participants completed the Emotion Regulation Questionnaire , to quantify self-reported suppression and reappraisal tendencies.
Upon chronic exposure to minimal doses of hydrogen peroxide , SH-SY5Y cells displayed a multifactorial response to the stressor.
Upon completion of baseline assessments , patients were randomly allocated 1 : 1 to exercise or usual care.
Upon completion of the study , @number@ treatment group participants and @number@ control group participants completed all assessments.
Upon consumption of H₂O₂ , glutathione is removed by glutaredoxin restoring KGDH activity.
Upon degeneration of iron-loaded microglia / macrophages , astrocytes may form an additional protective barrier that may prevent iron-induced oxidative damage.
Upon differentiation of HGPS-iPSCs , progerin and its ageing-associated phenotypic consequences are restored.
Upon EAE induction , the Nrf2-deficient mice crossed with the hIL6-BAC-Luc mice exhibited enhanced neurological symptoms concomitantly with robust luciferase luminescence in the neuronal tissue.
Upon exposure to Dox , cells stopped growing and underwent apoptosis.
Upon funding , future work will measure anthropometric and metabolic health directly.
Upon further validation , LAMP may be a valuable tool for routine Salmonella testing in produce.
Upon genetic analysis , a novel homozygous frameshift mutation was found in exon @number@ of the COL18A1 gene in the patient.
Upon genotoxic insults , TRIM25 dampened the p53-dependent DNA damage response.
Upon hypoxia and treatment with CoCl None : Micronutrient fortification can improve nutrient intake of older adults in long-term care.
Upon infection with mucogenic strains of RSV , leukocyte infiltration in the airways was elevated and prolonged in aged mice compared to young mice.
Upon infusion , plasma arginine increased from 48±7 to 189±23 μmol·l-1 ( means±S.D. ; P < 0.0001 ) .
Upon insulin stimulation , glucose uptake and glycogen synthesis increased but as the cellular proliferative capacity became gradually exhausted , the response dropped concomitantly.
Upon interaction with its receptors ( CD200Rs ) expressed on myeloid-derived cells and T lymphocytes , an immunoregulatory signal is delivered to receptor-expressing cells.
Upon in vitro culture , GCs were found to exhibit lower proliferation and increased apoptosis with aging.
Upon kidney injury , endogenous ligands can be released which are recognized by innate immune sensors to alarm innate immune system.
Upon multivariate analysis , age , LVH , heart failure , use of diuretics , and use of statins were the independent predictors of AF.
Upon oxidative stress , Peroxiredoxin ( Prdx ) @number@ is aberrantly Sumoylated by Sumo1 , resulting in loss of functions and cell death.
Upon phosphorylation , eIF4E weakly interacts with the @number@ CAP to inhibit mRNA translation.
Upon replication stress , RECQ5 associates with CFSs in early mitosis through its physical interaction with MUS81 and promotes MUS81-dependent mitotic DNA synthesis.
Upon returning to the room , the experimenter asked children whether they peeked and how the contents of the cup ended up on the table.
Upon statistical analysis , the elimination of these diseases would bring about only approximately @number@ additional years to the life expectancy.
Upon stimulation with angiogenic factors , vascular endothelial cells ( ECs ) secrete a negative-feedback regulator of angiogenesis , vasohibin-1 ( VASH1 ) .
Upon stimulation with LPS , CD56 + monocytes became more frequently positive for TNF , IL-10 and IL-23 than CD56- monocytes.
Upon UVB treatment , LKB1 or NUAK1 deficiency results in CDKN1A accumulation , impaired DNA repair and resistance to apoptosis.
Upper and lower body exercises were performed in the horizontal position.
Upper and lower body strengths were determined by one repetition maximum ( 1-RM ) chest and leg presses , respectively.
Upper and lower cheek sagging severity was evaluated by using photograph-based grading criteria.
Upper and lower extremity function was impaired in those who consumed a low protein diet compared to those with a higher protein intake.
Upper and lower lumbar lordosis were defined according to differences in anatomical sagittal mobility and kinematic behavior.
Upper arm circumference was associated with dementia ( p < 0.0001 ) but this association was only significant in the univariate analysis.
Upper body kinematics was assessed with a motion-measurement system.
Upper limits were dependent on gender and age.
Upper lumbar lordosis in the younger group changed dynamically in all changed positions compared with the old group ( P = 0.019 ) .
Upper / middle thoracic location and pT3-4a stage are independent risk factors for locoregional recurrence of pN0 esophageal squamous cell carcinoma after operation.
Upper to lower lip ratios were not significantly different between sexes or ages.
Upregulated miR-375 expression was associated with downregulated expression of 14-3-3zeta and SP1 genes.
Upregulated p16 , p53 , and p21 expression and silencing of E2F target genes have been characterized to promote the establishment of senescence.
Up-regulation of Arterial specification and differentiation are influenced by a number of regulatory pathways.
Up-regulation of BMP2 was first observed in NPC cell lines by a genome-wide transcriptome analysis in our previous study.
Upregulation of caveolin attenuates cellular proliferation and growth.
Up-regulation of extracellular matrix degrading proteinases matrix metalloproteinase @number@ ( MMP-1 ) , MMP-3 , and MMP-9 was noted.
Up-regulation of HO-1 was also found in brain glial cells in the aging and neurodegenerative diseases.
Upregulation of miR10b and miR23b is sufficient to induce ATSC cell apoptosis via p38 MAPK phosphorylation and caspase @number@ activation.
Upregulation of miR-29a and inflammatory cytokines IFN-γ , IL-6 , and IL-1β was also found in colonic biopsies from old baboons relative to young baboons.
Upregulation of mitophagy has shown to mitigate superfluous mitochondrial accumulation and toxicity to safeguard mitochondrial fitness.
Up-regulation of Notch4 was observed in the endothelial cells in the arteriovenous malformations ( AVMs ) in mice.
Up-regulation of proteasome activity is characteristic of muscle wasting conditions , but may not be rate limiting.
Upregulation of PTHR1 by 24-h pretreatment with @number@ nm dexamethasone rescued PTH stimulation of proliferation in hMSCS from elders.
Up-regulation of RbAp48 in the DG of aged wild-type mice ameliorated age-related hippocampus-based memory loss and age-related abnormalities in histone acetylation.
Upregulation of WNT / β-catenin pathway involves activation of PI3K / Akt pathway and then the Warburg effect to produce lactate.
UPSIT , but not Selective Reminding Test-total immediate recall , predicted cognitive decline in participants without baseline cognitive impairment.
Uptake of BrdU by Purkinje cells was observed in mutant Atxn1 knockin mice , suggesting their abnormal entry to the S-phase.
Up to 100microM , the other prostanoids were not significantly affected.
Up-to-date cryopreservation is a central component of contemporary human-assisted reproduction and fertility preservation technologies.
Up today , there are no effective therapies that allow to modify the disease course.
Up to now , few studies have been reported about the role of miRNA and long-noncoding RNA ( lncRNA ) in age-related OA.
Up to now @number@ genetic loci have been identified , each of them consisting of several single nucleotide polymorphisms ( SNPs ) .
Up to now only a few published case reports have been documented.
UP to now , oxidative stress has been recognized to be involved in human diseases such as high cholesterol , diabetes , and cardiovascular diseases.
Up to @number@ compounds were detected from human RSSC when analysed by GC-MS.
Up to @number@ controls were randomly selected for each case.
Up to @number@ @number@ deaths occurred.
Up to @number@ @number@ rounds of data collection at CHILILAB HDSS had been completed.
Up to @number@ patients per @number@ @number@ population per year are reported to suffer from sepsis , severe sepsis , and septic shock.
Up to @number@ repeated cognitive assessments by telephone interview were completed over @number@ years.
Up to @number@ variables are entered to calculate the indicators and to provide risk factor variables for the data analyses.
Up to @number@ waves of longitudinal cognitive data were collected from @number@ autopsied participants in @number@ ongoing clinical-pathologic cohort studies of aging.
Up to @percent@ of aged-matched control microglia displayed discontinuous or punctate features.
Up to @percent@ of aged subjects show morphological substrates of CVD in addition to AD pathology.
Up to @percent@ of heart failure patients suffer from lower urinary tract symptoms.
Up to @percent@ of hospitalizations might be attributed to depression.
Up to @percent@ of non-transported people who have fallen had unplanned health-care contact within @number@ days of the initial incident.
Up to @percent@ of the patients developed rapidly progressive cognitive deterioration , which further complicated the differential diagnosis with a neurodegenerative disorder.
Up to @percent@ patients received supportive care alone since diagnosis.
Up to the age of about 35-37 yr , workload and heart rate decreased with age , but afterwards the relationship became positive.
Up to the present , most research and development in this area has been done in the laboratory with young healthy control subjects.
Up until now there has been no objective criterion for the evaluation of these anatomical conditions.
Urban centers are increasingly ethnically diverse.
Urban dwellers showed better survival compared with their counterparts in the rural areas.
Urbanicity may explain some of the differences between the two samples.
Urbanization was viewed positively , but road accidents , crime and loneliness were significant concerns.
Urban minority populations in particular are affected by both the HIV / AIDS and chronic disease epidemics.
Urban participants used and valued recreational facilities , but rural participants did not report them as important in determining trips outdoors.
Urban residence and living status are the two significant factors that affect spending on personal hygiene products.
Urban residents compared with rural residents were more likely to be overweight and less likely to be underweight at nearly all ages.
Urban residents spend more on all services than do rural residents.
Urban residents , the married , and those with a higher income level tend to spend more on medical equipment.
Urea induces apoptosis of vascular smooth muscle cells as well as endothelial dysfunction , thus directly promoting cardiovascular disease.
Urea nitrogen concentration was higher , and total cholesterol was lower in AF associated patients , compared with the other two groups.
Urgent attention needs to be paid to capacity building of clinicians and academics for the future scholarship of Australian nursing.
Urgent measures should be established against non-cardiac mortality in this era of an aging population.
Uric acid also plays important roles in primates but causes gout when present in excess in humans.
Uric acid , a potent antioxidant substance , has been associated with bone mineral density but previous studies have yielded conflicting results.
Uric acid rapidly increased until the age of @number@ years , and then decelerated but continued to increase thereafter.
Uric acid ( UA ) is produced from purines by the enzyme xanthine oxidase , and elevated levels may cause arthritis and kidney stones.
Uric acid was the 3rd most frequent constituent in man , with a similar distribution between IIIa and IIIb.
Urinary acetoacetate levels were higher during the IF period suggesting a constant lipid catabolism.
Urinary concentrations of MEP showed a positive relationship with the number of personal care products used.
Urinary free cortisol ( UFC ) and creatinine ( Cr ) were measured , and a UFC / Cr ratio was calculated to standardize UFC.
Urinary function and bother decrease rates were similar by age.
Urinary glcUMOD concentration was substantially higher in DKD patients than non-diabetic CKD patients.
Urinary hydroxyproline and urinary deoxypyridinoline levels in the lead exposure group were significantly higher compared to controls.
Urinary IL-8 was a strong biomarker of stress under intensive and prolonged demands , both acutely and over time.
Urinary incontinence affects approximately three million women in France.
Urinary incontinence and prior year specialist visit were associated with increased odds of high anticholinergic burden.
Urinary incontinence is a widespread problem for women , with stress urinary incontinence ( SUI ) being the most common type.
Urinary incontinence is high even in early dementia at @number@ % , reaching @number@ % in severe dementia.
Urinary incontinence represents the most common PFD with an estimated prevalence of 15-17% , whereas fecal incontinence affects , approximately , @percent@ of adult women.
Urinary incontinence symptoms were assessed using validated questions.
Urinary incontinence ( UI ) is an international problem , affecting a high percentage of geriatric women.
Urinary incontinence was assessed by ICIQ-SF and caregiver burden by means of Zarit Burden Scale.
Urinary incontinence was categorized as any or moderate / severe urinary incontinence vs none.
Urinary KIM-1 had a modest association with all-cause mortality but did not associate with CVD , and urinary IL-18 did not associate with either outcome.
Urinary NGF and MCP-1 can serve as surrogate markers for monitoring age-associated biochemical changes and the effect of therapeutic interventions in OAB patients.
Urinary nitrogen excretion supported a preservation of whole body proteins , but large-scale urinary metabolomic analysis revealed an oxidation of some sulfur-containing compounds.
\ "Urinary symptoms \ " are similarly uninformative.
Urinary tract infection ( UTI ) developed in @number@ ( @percent@ ) .
Urinary tract infection ( UTI ) is a commonly diagnosed infection in older adults.
Urinary uromodulin is apparently glycated in DKD and forms AGEs , and glcUMOD may serve as a biomarker for DKD.
Urine and blood samples were collected , aliquoted , and stored.
Urine concentrating ability is reduced during normal aging in people and rats.
Urine cultures were obtained at admission , @number@ and @number@ days postoperatively.
Urine proteomics analysis is becoming a non-invasive and reproducible diagnostic method.
Urine samples from children with liver and kidney disease and urinary tract infection were excluded.
Urine was collected to analyze melatonin and serotonin urinary metabolites and to measure total antioxidant capacity.
Urocortin2 produced a time- and concentration-dependent prolongation of action potential duration.
Urodynam.
Urodynam.
Urodynam.
Urodynamic examinations were preformed before radical cystectomy.
Urokinase-type plasminogen activator receptor ( uPAR ) plays a role in cellular responses which include cellular adhesion , differentiation , proliferation and migration.
Urolithiasis is a common condition , with a prevalence of ∼10% and a male / female ratio above @number@ according to large national series.
Urological cancer rates may increase substantially amid a growing , aging population.
Urologic patients have a high prevalence of SD that is dependent on marital status , alcohol consumption , smoking status and aged patients with children.
Urologists have been concerned about the possibility of TRT causing prostate cancer.
Urologists must be attuned to the complications of surgery and develop strategies to minimize risk.
Uromodulin forms high molecular weight polymers that associate with microvesicles and exosomes.
Uromodulin is a protein with a renal protective effect , and may be subject to glycation.
Urosepsis was more common in females ; endocarditis and mediastinitis in men.
Urothelial ATP release was differentially mediated by intracellular Ca²⁺ release , cAMP , exocytosis , or connexins.
Urothelial ATP release was increased in aging bladders.
Urothelium-attached smooth muscle exhibited spontaneous contractions that were augmented by subthreshold concentrations of carbachol , which had little direct effect on smooth muscle.
URTI episodes were medically confirmed.
UR was defined according to Goldberg's classification.
US-assessed parameters were synovial hypertrophy , power Doppler signal , joint effusion , cartilage abnormalities , osteophytes , enthesopathy and bursitis.
USCOM scan quality is critical to obtaining reliable data and during anaesthesia it is said to deteriorate with increasing age.
US-derived TV might play an independent role in specific clinical conditions ( i.e. large hydrocele , inguinal testis , enlarged epididymis ) .
Use and interpretation of 18F-FLT requires knowledge of the physiologic tracer distribution and how it will be affected by anticancer treatment.
Used across settings within the health continuum , it allows for monitoring of individuals from relative independence through episodes of care.
Use data included number of log-ins and number of pages accessed.
Used in combination with the ACE-R , it provided additional value and identified almost all cases of aMCI / AD.
Used in physiotherapy programs improves the efficiency of physiotherapeutic exercises applied in different aliments.
Useful guidelines exist to guide clinical services integration.
Useful suggestions about how these findings may inform a specific cognitive intervention in older adults are also provided.
Use has increased predictably in the aged and infirm who have exhausted standard medical and surgical therapeutic options.
\ "Use it or lose it \ " is a popular adage often associated with use-dependent enhancement of cognitive abilities.
Use of an excessive number of standing balance measures has limited the synthesis of balance intervention data and hampered consistent clinical practice.
Use of antibacterials , based on current susceptibility patterns , is beneficial in patients with severe COPD experiencing exacerbations and in patients with severe exacerbations.
Use of antihypertensives showed positive association with females , higher age group , black skin color , overweight , and smoking history.
Use of a personality-based approach to patient counseling may encourage patients to discuss vaginal atrophy with their health-care provider and seek treatment.
Use of blood lipid lowering drugs was associated with greater reductions in TC and LDL after the training.
Use of cancer screenings were evaluated by asking the history of utilization of colon , breast , cervical , and prostate cancer screenings.
Use of caregiver supports showed mixed associations with burden.
Use of CCR in older adults without known do-not-resuscitate status is warranted.
Use of CG criteria or a similar algorithm appears to be warranted.
Use of continuous positive pressure in OSA patients is rewarding.
Use of corticosteroids was associated with approximately @percent@ fewer NPs and NFTs in most brain regions examined , compared with nonmedicated subjects.
Use of dietary supplements including multivitamins , vitamins , and minerals was repeatedly asked every @number@ years.
Use of dual health systems has been associated with worse outcomes.
Use of EBP : Health professionals reported wide-ranging use from several times each month to once every six months.
Use of flowable resin compromised the bond strength after simulated aging.
Use of geriatric consultation increased modestly in the latter years of the study period ( P < @number@ ) .
Use of gerontechnology is a synthesis of person , technology , and environment.
Use of head CT and clock test in PC are areas for improvement in Sweden.
Use of improved CNS-penetrating ART must be accompanied by evaluation of potential ART neurotoxicity.
Use of inconsistent acquisition parameters in VBM analyses is likely to introduce systematic bias.
Use of intravaginal DHEA , but not oral DHEA , alleviates vaginal atrophy and improves sexual function in postmenopausal women.
Use of minimally invasive biospecimen collection and education to promote awareness of biospecimen research were suggested facilitators to increasing biospecimen research participation.
Use of @number@ or more medications commonly is used.
Use of oral melatonin is also effective for the improvement of nocturnal sleep.
Use of other cardiovascular and psychotropic medication was not associated with fall risk.
Use of PEG-IFN / RBV with novel direct antiviral agents will likely be still maintained until less expensive and effective interferon-free strategies become available.
Use of pharmacological and nonpharmacological interventions of MDs and NPs were similar.
Use of physical restraints is not recommended for fall prevention.
Use of print-based materials among the initial Web-based participants was substantial , indicating the importance of print-based materials.
Use of psychotropic medications on the Beers list also increased with less urban residence ( @number@ vs. @percent@ , p = @number@ ) .
Use of self-reported estimates for individual assessments should be discouraged.
Use of statins increased more than fourfold during the @number@ years.
Use of the bacterium Wolbachia is an innovative new strategy designed to break the cycle of dengue transmission.
Use of the proposed novel ThickNet features demonstrates significant improvements over previous experiments using cortical thickness alone.
Use of these supplements may be a risk factor for idiopathic cerebral venous thrombosis.
Use of thiotepa is strongly associated with permanent CIA.
Use of this in clinical practice may allow better prediction of chemotherapy-related risk to future fertility.
Use of traditional methods for treating anemia was common.
Use of universal design principles could enable greater inclusion of people with disabilities in health promotion interventions for the general aging population.
Use of urine samples results in a decreased need for blood sampling , which is especially beneficial in pediatric patients.
Use of verbal mediators was more likely for the more concrete person sources for which source memory was generally better.
Users are generally accepting of workstation alternatives ; however , there is evidence of less than optimal use.
Users can fluidly interact with an entire collection of cortical surfaces using only their mouse.
Users can trace the entire process of ion-binding state analysis step by step.
Users ( n = @number@ ) were asked about ' usability'.
Users of BBB-crossing ARBs showed superior memory performance over time compared with other antihypertensive drug users and had less WMH volume.
Users of informal care received @number@ hours of informal care / month in small municipalities , @number@ in mid-size municipalities and @number@ in urban areas.
Users were asked about any adverse events experienced after each session as a safety measure.
Use the Older Worker Lure Scale to rate your organization's ability to attract and retain older nurses.
Use was coded as a time-dependent variable.
U-shaped associations were observed regardless of diabetes status , sex , age , and smoking history.
Using 3D , we interrogated over @number@ billion mitochondrial genomes to analyze the age-related dynamics of mtDNA deletions in human brain tissue.
Using 3T magnetic resonance imaging , lesions were classified as DWMH or PV.
Using a 52-saliva sample training set , two age-predictor models were developed by means of a multivariate linear regression analysis for age prediction.
Using a 7-day diary and accelerometry , this study investigated destinations and purposes of walking in older adult residents of an ultra-dense Asian city.
Using a combination of techniques , Nichols et al. have identified two residues ( Ser910 and Ser935 ) that are critically responsible for 14-3-3 binding.
Using a compendium of @number@ mammalian mtDNA , we re-examined the relationship between species lifespan and the mutagenicity of such DRs.
Using a complex reaction time ( RT ) task , greater IIV and mean-RT were related to a higher WMH burden in the frontal lobe.
Using a cutoff of ≥4 blocks , @percent@ ( N = @number@ ) of men were characterized with hyperkyphosis.
Using a cut score of @number@ the sensitivity and specificity of the PHQ-9 were @number@ and @number@
Using a dynamic microsimulation model , this paper explores the ability of alternate future stock market scenarios to restore retirement assets.
Using a dynamic panel data model , we then estimate short- and long-run effects of changes in health on wealth.
Using a familial approach , we investigated the relationship between parental longevity and offspring's dispositional optimism among community-dwelling older subjects.
Using Affymetrix® GeneChip , the expressions of @number@ antioxidant-related gene probes were analyzed to estimate the differences in gene expression between the four subject groups.
Using a focus group methodology , this study explored the experience of active older volunteers who participated in an intergenerational service-learning project with college students.
Using age as a continuous variable , @number@ peptides significantly correlated with age in mice were identified.
Using age as a predictor , linear regressions were performed for each dependent variable.
Using a gel-LC-MS / MS approach , we identified @number@ protein clusters from @number@ dissected adult fly hearts.
Using a genetically engineered expressed Ca2 + indicator , we report changes in cardiac Ca2 + handling at two different ages.
Using a grading scale of @number@ to @number@ the average SMAS thickness was @number@ for the primary and @number@ for the secondary rhytidectomy patients.
Using a history of prior falls in preoperative risk assessment for an older adult represents a shift from current preoperative assessment strategies.
Using a human-rights-based framework , the legislation is analyzed for its strengths and weaknesses.
Using a hypothetical model , we identify possible interventions to increase the healthy life years in people with ID.
Using a linear regression model , we built a transition algorithm for the maintenance dosages of warfarin and fluindione.
Using all available EMR data , we developed and improved our algorithms in the derivation cohort and validated them in the independent validation cohort.
Using all @number@ inflammatory markers , an inflammation composite score was created for each participant.
Using a luciferase reporter system , we assessed miR-181b binding to ALX / FPR2 @number@'-UTR.
Using a measurement burst design , the one-week sampling procedure was repeated five and then ten years later.
Using a mediation model , sleep was revealed as a mediator of the association between stress experience and serum BDNF levels.
Using a mixed-methods methodological approach , the proposed study examines the associations between economic well-being and independent living experiences in foster youth.
Using a multiple-case study , @number@ participants representing @number@ families comprising three or more generations participated in individual , semistructured interviews.
Using a myocardium-specific marker , the fraction of myocardium colocalizing with PAOs ( PAO burden ) was quantified ( green / red ratio ) .
Using an alternative method , we have identified missed expansion carriers in our cohort , and this number has increased by approximately @percent@.
Using analytic hierarchy process , the weight of dimensions and items were determined.
Using a national sample from @number@ we determine if the quality of post-acute care provided by CCRC nursing homes is superior to traditional nursing homes.
Using a new GLB1 antibody , senescence biology was investigated in prostate cancer ( PCa ) tissues.
Using an intertrial technique previous research has investigated whether this deficit can be attributed to a decline in encoding or consolidation.
Using a nominal P ≤ @number@ × 10 ( @number@ ) significance threshold , @number@ SNPs were associated with CVD risk in single locus analyses.
Using a novel biopanning technique that combines phage display technology and atomic force microscopy , we isolated the nanobody E1 against oligomeric Aβ.
Using a novel virtual Y-maze strategy assessment ( vYSA ) , the present study demonstrated substantial age differences in strategy preference in humans.
Using APAs in older adults significantly reduces the need for large CPAs , resulting in greater postural stability following a perturbation.
Using a placental explant culture model , we tested the hypothesis that aldehyde oxidase @number@ mediates oxidative damage to lipids in the placenta.
Using APPswe / PS1dE9 mice , a transgenic model of AD , we showed that TREM2 was upregulated in microglia during disease progression.
Using a proteomics-based screening method to screen plasma for potential biomarkers , we previously found inflammatory glycoproteins to be increased with frailty.
Using a qualitative descriptive approach and qualitative content analysis method , @number@ healthcare professionals were interviewed in Ontario , Canada.
Using a recently established method , we quantified total GS levels in cerebrospinal fluid ( CSF ) from AD patients and control subjects.
Using a representative sample of older adults living in Detroit , this study examined the association between age-friendly environment factors and self-rated health.
Using a retrospective cohort design we analyzed weighted data from 1998-2007 for.
Using a single birth cohort , age was excluded as confounding factor.
Using a size classification task , Experiment @number@ showed equivalent associative priming between young and older adults.
Using a speeded word fragment completion task , we assessed age differences in the automatic accessibility of emotional versus neutral words from semantic memory.
Using a standardized appraisal process , reviewers rated each tool's psychometric properties , including its predictive validity with on-road performance.
Using a standardized scale , the volume grade of the nasal and central fat pads was graded from @number@ to @number@
Using a stratified multi-stage cluster sampling process , the baseline data was collected through the self-administered structured Village Doctor Questionnaire.
Using a strengths based approach , we examined the factors that facilitated physical activity in our sample of highly active older adults.
Using a structured methodology , participants achieved consensus on recommendations for a research agenda on aging and environmental sustainability.
Using a summary metric derived from the hypergraph formalism-hypergraph cardinality-we investigate individual variations in two separate , complementary data sets.
Using a systems approach , we further analyzed the role of @number@ genes in LRO biology.
Using a template organizing style of analysis with immersion / crystallization , themes of barriers and facilitators were coded for adaptive challenges and leadership.
Using a tether-release method to perturb balance and simulate a forward fall , center of mass and stepping characteristics were analyzed.
Using a time-series algorithm limited to features calculable on the wrist device , moreover , achieved an AUC of @percent@.
Using autophagic bulk degradation cells can clear crosslinked macromolecules and damaged organelles that arise under redox stress.
Using baseline demographic and clinical variables in proportional hazards models , we derived scores that predicted the risk of progressing from CN to MCI.
Using behavioral self-regulation processes may facilitate exercise among older women with heart disease.
Using biochemical and immunoblotting methods , mitochondrial function and phosphorylated Tau were measured.
Using biochemical , molecular biology , immunostaining and transmission electron microscopy ( TEM ) methods , we studied DDQ's beneficial effects in AD neurons.
Using bioinformatic analysis , we identified over a thousand of human L1 loci containing at least one stop codon in their ORF1 sequence.
Using blood taken from a Mexican-American extended pedigree sample ( Pulmonary fibrosis is a severe condition with no cure and limited therapeutic options.
Using body-worn accelerometers , we developed several novel camera-less methods to analyze head and pelvis movements while walking.
Using bootstrapping methods , we found that executive function partially explains the relationship between both personality dimensions and health behavior.
Using both cell extracts and recombinant proteins , CSB and NEIL2 were found to physically interact independently of DNA.
Using both HapMap and 1000G imputation we performed a meta-analysis of @number@ studies comprising the same @number@ individuals.
Using brain magnetic resonance imaging , volume of WMH was measured @number@ times in an average of @number@ months apart.
Using canonical correlation analysis and structural equation modeling , an individual score of AMP was created and correlated with RSMM.
Using cerebellar gray reference , 18F-T807 data were expressed as standardized uptake value ratio , and 11C-PiB were given as distribution volume ratio.
Using clinical practice as the starting point , the goal was to reproduce the clinical diagnosis.
Using collagenase digestion , we isolated cells from small fragments of pulmonary artery dissected from non-CF lobes or explanted CF lungs.
Using Comet assay , we found the DNA breaks in the LECs of ARCCs were obviously severer than that of controls.
Using complete employment histories , employment gaps of ≥6 months between ages @number@ and @number@ were identified.
Using confirmatory factor analysis , we compared first-order and bifactor models to investigate whether specific tract-ability associations were accounted for by g.
Using consistent non-tea consumers as the reference , only consistent tea consumers had reduced risk of NCD ( OR = 0.39 ) .
Using content analysis techniques , transcribed interview data were coded and categorized.
Using Cox proportional hazards models , we related CMB presence to incident dementia.
Using Cox proportional hazards regression , associations between smoking characteristics and overall , CRC-specific , non-CRC related , recurrence-free and disease-free survival were evaluated.
Using Cox regression , we determined the associations between serum adiponectin concentration and all-cause and cardiovascular mortality after adjusting for well-known cardiovascular risk factors.
Using cross-sectional and longitudinal data from a national sample spanning the adult life span , age differences in anger and sadness were explored.
Using CSF Aβ42 as a biomarker we replicated genetic influences in APOE and observed a significant influence of a new haplotype in PSEN2.
Using cultured hippocampal neurons as a model system , we found that presynaptic terminals become significantly larger in response to the application of Shh.
Using customized qPCR panels we quantified the expression levels of miRNAs detected in the screening procedure ( @number@ miRNAs ) .
Using data from Finland , this research examined a life course model linking childhood differences in cognitive skills and antisocial propensity to midlife socioeconomic exclusion.
Using data from more recent epidemiological studies , this review proposes an alternative model of the natural history of genital HPV across the life span.
Using data from over @number@ participants , we traced the ability to learn new faces from pre-adolescence through middle age.
Using data from the 2008-2009 and 2011-2012 waves of the Chinese Longitudinal Healthy Longevity Survey , we apply structural equation models to estimate these effects.
Using data from the Group Insurance Commission in Massachusetts , we show that adverse selection and aging in place are both quantitatively important.
Using data from the Health and Retirement Study , I show that wives delay retirement when their husbands retire following a job loss.
Using data from the literature , the treatment gap was estimated.
Using data from the Nutrition and Function Study , @percent@ reported high levels of depressive symptoms and @percent@ indicated not receiving needed health care.
Using data from the PAQUID cohort on cognitive aging , we jointly studied cognitive decline , dementia risk , and death risk.
Using data from the prior studies , linear regression was used to generate such formulae in the Indexes and subtests of the RBANS.
Using data from the Victoria Longitudinal Study , we tested @number@ cognitive outcomes : fluency , episodic memory , reasoning , and vocabulary.
Using deep sequencing , we detected over @number@ expressed genes , including hundreds of cell-type-enriched mRNAs , lncRNAs and pri-miRNAs.
Using dense genotyping in individuals of European , East Asian , South Asian and African ancestry , we narrow association signals in @number@ loci.
Using diffusion tensor imaging and white-matter parcellation , @number@ fiber bundle integrities were compared between the two genotype groups.
Using drug-gene interaction data , we also performed a functional enrichment analysis of targets of lifespan-extending drugs.
Using DTI , we attempted to investigate age-related changes of the fornix in the human brain.
Using each individual as his own control , we defined a group with a large degree of cognitive decline , and a control group.
Using elbow motion outcomes two UEF indexes were developed ( categorical and score ) .
Using enzyme-linked immunospot assay , an increased number of splenic immunoglobulin-secreting B-cells from T3-treated mice was detected ex vivo.
Using estimates from @number@ cross-sectional cohorts , both frailty and pre-frailty were associated with higher odds of CVD than robust participants.
Using event-related functional magnetic resonance imaging , we compared activity for successful versus unsuccessful trials during a source memory task.
Using event-related functional magnetic resonance imaging , we investigate the effects of aging on source memory and associated neural activity for words and objects.
Using evolutionary analysis and the Alu retrotransposition assay , we sought to identify additional amino acids in the C terminus important for retrotransposition.
Using experience sampling , we quantified the incidence of AM and PM in natural settings among various age groups.
Using exploratory factor analysis , the underlying factor structure of the ASCOT and the ICECAP-O was examined for the first time.
Using expression in the EC for normalization , we identified @number@ genes that manifested reliable age-related changes in the DG.
Using eye movement metrics this paper reports findings that question the congruency of the three conditions.
Using factor analysis , we determined whether the LLDI's factor structure was comparable with that reported previously.
Using family relationships , we identified @number@ segregating expression outliers ( median z score of @number@ ) , averaging @number@ genes per individual.
Using fast spin-echo imaging with multiple echo times , T ( @number@ ) maps were produced and warped to a study-specific template.
Using final diagnosis at time of death , @number@ of @number@ ( @percent@ ) ProbPD cases had confirmed PD.
Using five different instruments examining remission , we report that aging did not adversely affect remission in the elderly.
Using flow cytometry , we found that CPP-conjugated liposomes improved cellular uptake of the fluorescent dye as compared with the typical liposomes.
Using fMRI , participants intentionally formed impressions of positive and negative face-behavior pairs in anticipation of a memory task.
Using functional MRI , we examined the effects of age during search and elaboration phases of AM retrieval.
Using G8 with ECOG-PS may be helpful in deciding treatment for elderly patients with advanced cancer.
Using general linear models , we analyzed participation in activities in relation to type of surgery and bowel function after adjustment for potential confounders.
Using gene set enrichment analysis , we identified a 19-gene signature enriched in indolent prostate tumors.
Using GeroScope pathway analysis and drug discovery platform we analyzed the activation states of @number@ major cellular signaling pathways.
Using group-based trajectory modelling , we generated trajectories of dietary scores and empirical patterns in @number@ B and @number@ K Cohort children.
Using Hi-C data analysis , we show that interactions of NADs dominate interphase chromosome contacts in the 10-50 Mb distance range.
Using histological and immunohistological analysis of whole mammary glands at different stages of development , we detected no significant changes between normal and gal-7-deficient mice.
Using history , examination , and laboratory testing , the clinician can evaluate the patient with dementia.
Using immunohistochemistry on temporal cortex sections , CD33 was selectively localized to microglia , with greater expression in activated microglia.
Using immunohistochemistry , the localization of Gal-3 and AGEs in tissue isolated from chronic wounds and non-involved skin from the same patient was investigated.
Using immunohistochemistry , trypsin-2 was detected in microglial cells located in the vitreous and the retina.
Using independent component analysis network maps derived from normal young subjects to extract all individual functional connectivities provides significant correlations with clinical evaluations.
Using innovative styles to cut beef allows for greater merchandising options.
Using in vitro models , we determined the cell types responsible for periostin expression and performed functional analyses with periostin knockdown cells.
Using in vitro studies , we demonstrated that pioglitazone attenuated reactive oxygen species levels in aging human umbilical vein endothelial cells through PPAR-γ activation.
Using item-response models , survey-adapted items captured a broad range of cognitive abilities and functioned similarly across sex , education , and ethnic groups.
Using Item Response Theory , we examined Test Information Function ( TIF ) curves to eliminate less informative items and devise plausibly distinct subscales.
Using Kaplan-Meier analysis , retreatment-free survival rates by initial surgical procedure were compared.
Using knockout dermal fibroblasts , we confirmed its role for Brucella but found that it is not required for Salmonella infection.
Using latent growth curve analysis , we found that the frequency of in-person contact with family members remained relatively stable across the life span.
Using latent profile analysis ( LPA ) , clusters of life events were identified and associations between life event clusters were tested.
Using latent variable analyses , we examined whether age differences in regional white matter integrity mediated age-related differences in executive functions and speed of processing.
Using lens photographs , we graded cataracts by the Age-Related Eye Disease Study system.
Using LEW1 primers , 13·3% of the samples were confirmed positive for T. lewisi , both by PCR and sequencing.
Using linear mixed-effects models we show differences between those with symptomatic AD and controls.
Using live imaging , we demonstrate that asymmetric division resulting from a cell containing a single inclusion body produces sister cells with different fates.
Using log-binomial regression analyses , we analysed whether psychosocial factors at work predicted 5-year deterioration of SRH.
Using logistic regression analysis in the @number@ community-dwelling males , we assessed the ability of numerous potential clinical risk factors to identify male with osteoporosis.
Using logistic regression controlling for confounders , SCREEN II scores trended towards an inverse association with CVD ( p = 0.10 ) .
Using longer term follow-up with proper adjustment for attrition and incident cases increases estimates of risk.
Using LTA analysis , we identified genetic loci influencing BP.
Using machine-learning algorithms , we identified sociodemographic correlates of disability.
Using machine learning , we arrived on a set of four predictors , all of which reflect the functioning of the cardiovascular system.
Using magnetic resonance imaging , we examined cortical thickness and resting state functional connectivity.
Using mandibular canines ( n = @number@ ) , the distribution of perikymata per decile was recorded using high definition replica surfaces.
Using measurements , the AD at the ascending-aorta ( AA ) , proximal-descending-aorta ( PDA ) and distal-descending-aorta ( DDA ) was determined.
Using meta-analysis , the weighted mean prevalence of YFAS food addiction diagnosis was @percent@.
Using mice that were exposed to cigarette smoke , SKI-II induced Nrf2 expression together with HO-1 in their lungs.
Using microarray analysis , our findings indicated that the gene expression profiles induced by serial subculture are distinct classes of gene.
Using microarray analysis , we identified @number@ genes regulated by Rorβ in an MC3T3-E1 mouse osteoblast cell model ( MC3T3-Rorβ-GFP ) .
Using microRNA array screen , we found the expression levels of @number@ unique miRNAs in hyperplasic tissues.
Using minigenes carrying deletion mutations within intron @number@ we demonstrated that this sequence functions as an intronic splicing enhancer.
Using modified Poisson regression , we examined the likelihood for Chinese workers of experiencing adverse exposures compared to whites.
Using MRI-navigated TMS and multichannel EEG , we compared the EEG-MEP interactions observed in healthy aged subjects with those observed in young volunteers.
Using MRI , we compared brain structure , function , and connectivity between @number@ people with GHRD and @number@ unaffected relatives.
Using MRS along with dual energy x-ray absorptiometry , studies have reported a detrimental role of BMF on BMD.
Using MTS assay , we found that PYP1-5 did not affect cell viability.
Using multicolor lineage-tracing and organoid-formation assays , we identified the presence of a progenitor-like acinar cell subpopulation.
Using multilevel modeling , we modeled the individual differences as well as stability in arthritis pain and depressive symptoms simultaneously.
Using multiple linear mixed models , we evaluated the associations between hormones and metabolites.
Using multiple linear regression analysis , the association between AGEs and sRAGE remained significant after adjustment of other clinical factors.
Using multiple linear regression analysis , we drew a predictive equation for DXA-measured ASM by BIA resistance.
Using multiple regression methods controlling for potential confounders , we compared in-hospital mortality and long-term survival after discharge between the groups.
Using multivariable linear regression , we estimated the proportional change in mean BMeHg associated with a doubling of the ADMI.
Using multivariate analysis , only age retained significance.
Using multivariate logistic regression , factors related to classification of VCmax = FVC or VCmax > FVC were estimated.
Using multivariate logistic regression , the significance and independence of the relationship of life-space mobility with NH admission were examined.
Using mutants , we show that Gcp depletion results in accumulation of AMPs and eventually leads to the accumulation of AGEs.
Using negative binomial regression , we obtained both relative risk estimates and absolute rates , that is , days of work disability per person-year.
Using new locking plates , early mobilization could be maintained even in an aging population.
Using NHANES III data on calcium intake and bone mineral density , the most important non-linear methods are introduced and discussed.
Using nonlinear regression within both samples , we compared mean and percentile rank estimates of whole brain tissue volume by age.
Using notification rate ratios ( NRR ) , we compared results in those aged ≥65 years to those aged 20-64 years.
Using @number@ national data , we investigate the relationship between social integration and health insurance for African American adults.
Using number of events in celiac patients and referent patients , we calculated a summary relative risk of pneumococcal infections.
Using @number@ μM of conjugated Pt-nps , the lifespan of N2 and LB25 was maximally extended.
Using office spirometry , primary care physicians can diagnose the presence and severity of COPD.
Using original and operationalized ARWMC scale , eight observers recorded the time for rating per MRI and per CT.
Using our optimization framework , we demonstrate that the optimal pipelines tend to be highly similar across age cohorts.
Using our predictive model , we conducted a preliminary study focused on facial shape alterations induced by reductions in body weight.
Using path analysis , we determined that race , neighborhood poverty , education , and income did not influence physical function or emotional well-being.
Using Pearson's correlation coefficient , the value of which was @number@ ( p < 0.05 ) , we observed a positive correlation.
Using pedigrees it was possible to calculate the heritability of the trait.
Using pictorial stimuli in a perceptual identification task , we examined whether new association priming can occur at a purely perceptual level.
Using Poisson regression , incidence rates and adjusted incidence rate ratios were calculated to determine the association of HIV with pulmonary disease.
Using Poisson regression , we modeled the association between physical ability , job demand , and self-reported occupational injury.
Using precise methodology , Hall et al.
Using predefined classification criteria the specificity of the visibility across all age groups reached approximately @percent@.
Using predefined cutoff criteria , experts identified @number@ medical student and @number@ IM / FM resident competencies as essential.
Using predetermined methodological criteria , we evaluated the effect of diabetes-specific self-management programme interventions in older adults.
Using principle component analysis , two major dietary patterns and eight minor dietary patterns were characterized.
Using process tracing software and an algorithm developed to assess decision strategy , we recorded search behavior , strategy selection , and final decision.
Using projective mapping , changes in sensory properties were observed with powder addition.
Using proteomic techniques , a site of deamidation involving glutamine @number@ has been characterized and its time course established.
Using PubMed and Medline , we identified @number@ articles with blood pressure data from unacculturated or partially acculturated populations.
Using purposeful sampling from each of the embedded units , @number@ students were interviewed.
Using quantitative middle-down proteomics we demonstrate that H3.3 accumulates to near saturation levels in the chromatin of various mouse somatic tissues by late adulthood.
Using RabMab42-3 , we show that the subcellular localization of endogenous HPV-16 E7 oncoprotein varies during the cell cycle in cervical cancer cells.
Using random coefficient models , interpersonal behaviour scores at very mild , mild or moderate-to-severe disease stages were compared within and between patient groups.
Using rank-based statistics we not only recovered known comorbidities but also discovered a novel association between COPD and digestive diseases.
Using Rea small interfering RNA to knock down Rea expression enhanced Rorγt expression and Th17 differentiation.
Using relative concentrations , the total of all fatty acids is summed to @percent@ and thus the values of individual fatty acid are not independent.
Using relevant databases and keywords , @number@ studies that met the inclusion criteria were reviewed and where possible , a meta-analysis was performed.
Using relevant databases and keywords , @number@ training and @number@ cross-sectional studies that met the inclusion criteria were reviewed.
Using renal mitochondrial matrix CYGAK , CYGAK-OC , and CYGAK-ON had IC ( @number@ ) 's of @number@ @number@ and @number@ nM , respectively.
Using reporter assays we show that miR-196b specifically increases the translation of the reporter protein luciferase.
Using researchers ' analytic memos , we identified facilitators ' interactional strategies that fostered the participant's sense of personal identity , dignity and social self-worth.
Using resting-state fMRI scans , we assessed whole-brain functional connectivity to frontoinsular , anterior midcingulate , and posterior cingulate cortices.
Using RFR as a reference , FFR showed a better discrimination and reclassification ability than resting indices.
Using Role Strain Theory and Socioemotional Selectivity Theory , this study examines how older grandmothers fare relative to their younger counterparts.
Using RT-PCR and IHC , we found that these hAMSCs expressed pluripotent genes , such as @date@ Sox2 , and Nanog.
Using SAX-derived intelligent icons , those with no difficulty showed high variations of transitions across all activity levels.
Using selected titration protocols , electrons are provided to specific sites of the electron transport chain , allowing evaluation of mitochondrial function.
Using semiquantitative histologic measures of plaque and tangle pathology , we saw no significant differences between the different genotypes within these disease groups.
Using single-molecule PCR , we have characterized more than @number@ @number@ de novo somatic mutations from a large cohort of DM1 patients.
Using single voxel MR spectroscopy , we predicted that higher levels of education would moderate an age-related decline in NAA in the frontal cortex.
Using specific point mutants , we further show that recognition of the chromatin mark H3K4me3 is essential for induction of senescence by p33ING1.
Using SPM , age- and sex-associated changes in cerebral glucose metabolism were investigated.
Using standardized procedures , surface electromyograms were recorded from the vastus lateralis and medialis , rectus femoris and the medial and lateral hamstrings.
Using statistical image processing , we identified the features of mental representations that predict perceived age.
Using STC1 plasmid , it was possible to enhance the ability of MSCs to ameliorate the fibrosis.
Using stepwise backward multivariate analyses , we defined which set of clinical and biological variables could be predictive of increased total and differential WBC counts.
Using stepwise-like model selection procedure , we built mixed-effects models for initial cognition and longitudinal cognition.
Using structural and functional measures and task performance , the roles of CR were tested using path analysis.
Using structural equation modeling ( SEM ) , rape was associated with lower self-esteem , psychological , and physical health functioning.
Using structure-based optimization of the analogs , FK-A11 was identified as the most potent analog.
Using such programs to present aging-related content can be a constructive pedagogical device , offering a means of actively engaging students.
Using synthetic peptide dilution series , we show that the sensitivity , dynamic range and reproducibility established with SWATH-mass spectrometry are uniformly achieved.
Using tDCS , we then tested hypotheses for the specific roles of the parietal and frontal cortices found in the fMRI experiment.
Using texture features engineered by texton filter banks , we provide a suite of effective segmentation methods for this problem.
Using the assay , a significant 3- to 5-fold increase in Aβ oligomers in human AD CSF compared with comparably aged controls was demonstrated.
Using the Baron and Kenny approach , we then investigated the associations between education achievement and incident T2DM with the potential mediators.
Using the buccal swab , the savings was US $ 6.72 per patient ( P < @number@ ) .
Using the classical twin design , TRM heritability was estimated ( N = @number@ MZ = @number@ DZ = @number@ ) .
Using the classification helps to tailor an appropriate treatment to the individual patient and aids to achieve a natural rejuvenation result.
Using the combination of this autopsy and MRI data , this study will make it possible to estimate in vivo states.
Using the delta method , approximate p-values were calculated for the pairwise comparisons between methods.
Using the developing mouse spinal cord as a model system , we identify molecular changes that occur in developing astrocytes.
Using the electronic Hospitalization Summary Reports , we identified @number@ patients with colorectal cancer who underwent surgical resection from @number@ through @number@
Using the EMG signals , the electrical activity and median frequency ( MF ) are calculated per cycle.
Using the first wave as a baseline , the data included @number@ individuals aged @number@ years and older with at least one living child.
Using the fly model for tauopathy / AD , we investigated the effects of an exposure to dim light at night on AD symptoms.
Using the hydraulic resist practicing equipment as the mainstay intervention can help examinee collecting the practice value and further analysis.
Using the Illumina Infinium @number@ K Human Methylation Array , we examined more than @number@ CpG sites distributed across the genome in buccal epithelial cells.
Using the inattentional blindness paradigm developed by Most et al.
Using the known-groups technique , we validated the instrument , showing that it discriminates between the knowledge of first- and third-year nursing students.
Using the Macnab score , good to excellent results were achieved in @percent@ of the patients.
Using the methodology of system dynamics , models are developed to explore how interpersonal relationships influence older adults ' participation in oral health promotion.
Using the NBRF , decision making was formalized by incorporating values of willingness to pay ( WTP ) a priori.
Using the noise measurements , we built a neuronal model.
Using the Patlak pharmacokinetic model , we calculated the leakage rate.
Using the PDLSC-Bmi1 , we confirmed the promotive effect of naringin on osteogenesis.
Using the predicted geometrical changes , the optical response of the whole eye during accommodation was analysed by ray-tracing.
Using the quantitative study results , the qualitative study phase will be conducted by interviews in sub-groups of older people.
Using the related-articles link , additional articles were screened for inclusion.
Using the reported residential address , each participant was linked to the @number@ Census at block-group level to retrieve the above-mentioned neighborhood characteristics.
Using the same cell model , the present study examines the metabolism / processing of the amyloid precursor protein ( APP ) .
Using the scale in relation to other psychometric and demographic measures provided three important , novel findings.
Using these CoVs of UA , the participants were divided into normal- and high-level groups of UA.
Using these criteria , successful aging status was defined in @number@ ( @percent@ ) subjects.
Using these cutoff levels , the sensitivity of GA at @percent@ for detecting diabetes was the same as that of HbA1c.
Using these data , a decision would be made to stop , continue , or change therapy.
Using these data , we matched age distribution patterns in mice and in humans , allowing for age differences by shifting either of the patterns.
Using these diagnostic criteria , only @percent@ of 40-80-year-old men have LOH.
Using these estimates , normograms for the weight change were developed.
Using these findings , gerontological nurses are well positioned to deliver tailored stress management and forgiveness interventions when older adults report increased stress.
Using these models , the accommodation of a broad range of lenses with different geometries and mechanical properties were investigated.
Using these WBC cutoff values , the hazard ratio ( HR ) for females was significant in both the study group and validation group.
Using the Social Participation Questionnaire , the relationship between social support and social participation was investigated in @number@ Iranian older adults.
Using this alternative interpretation , we show that faster increases in life expectancy would lead to slower population aging.
Using this equation , the peak victory rate reaches @percent@ at @number@ yr for number @number@ ( no.
Using this information , the application generates recommendations and personalized goals for weight loss.
Using this knowledge , several scores have been created to improve predicting overall survival and / or treatment-free survival.
Using this method , urinary menadione was shown to increase in response to @number@ years of phylloquinone supplementation.
Using this method , volume restoration can be achieved naturally and progressively over a period of time.
Using this model , we have analyzed UVA-induced transcriptomic and proteomic changes in corneal stroma.
Using this model we modified the inhibitor to improve potency 2-fold ( CYGAbuK ) .
Using this novel approach , we found that miR-9 controls dendritic growth and synaptic transmission in vivo.
Using this predictor , we identified slow and fast agers that are significantly supported by levels of health indicators.
Using this process , we demonstrated its superiority to the traditional \ "one-pot \ " strategies for differential protein identification.
Using this protocol , we showed that VF adduction is impaired in primary aging mice , whereas VF abduction is impaired in ALS-affected mice.
Using this system , we effectively eliminated xenografted normal human senescent fibroblasts or induced senescence in human breast cancer cells in vivo.
Using this system , we show that expression of NANOG fortified the actin cytoskeleton and restored contractile function that was impaired in senescent MSCs.
Using this technique we show that genetic or age-dependent changes that modify the long-term enhancement or suppression of aggrephagy can be identified.
Using this type of gait analysis in clinical practice could facilitate screening for cognitive impairment.
Using three computational approaches - miranda , pita and rnahybrid - these differentially expressed miRNAs were also predicted to target @number@ bovine genes.
Using three different mouse models , we found TR4 could prevent or delay prostate cancer ( PCa ) / prostatic intraepithelial neoplasia development.
Using three-wave panel data from the Norwegian county of Nord-Trøndelag , the HUNT study allows the study of respondents over two decades.
Using thymidine analogues-based DNA double labelling technique , we further established decline in germ cell proliferation and differentiation.
Using time-synchronized ground-truth blood pulse waveforms , spatial correlation priors were computed and projected into a coaligned importance-weighted Cartesian space.
Using TMS , we examined age-related alterations in maps devoted to biceps brachii muscle to determine whether they predicted its age-induced weakness.
Using transcranial magnetic stimulation , representation of biceps in M1 was identified.
Using transformative learning within gerontology and geriatrics education , as well as other disciplined aging-related courses is discussed.
Using Transwell® migration assays , we show that Chemerin enhances the chemotaxis of different cSCC cell lines.
Using T-scores , approximately 15%-20% and 5%-10% of scores were > 1.0 and > 1.5 SD from the mean , respectively.
Using TUG time alone , frailty status was classified correctly with mean classification accuracy of @percent@.
Using two-way ANOVA , we assessed the influences of age and education on test scores of old adults ( 61-84 years of age ) .
Using UA as one of the metabolic biomarkers may help clinicians to early detect and prevent MetS and diabetes.
Using ultrasound before surgery allows the planning of the optimal incision in @percent@ of cases.
Using ultrasound , measurements were taken at @number@ landmarks on the faces of @number@ individuals aged 18-75 years old.
Using weighted data , descriptive analyses and logistic regression analyses were conducted.
Using well-established SMC differentiation models , we have demonstrated that miR-34a has an important role in SMC differentiation from murine and human embryonic stem cells.
Using yeast two-hybrid methods , we identified a large set of proteins that interact with huntingtin ( HTT ) -interacting proteins.
Using Yin's exploratory case study design , @number@ fourth-year nursing students constituted the single case.
US inpatient capacity increased until the 1970s , then declined.
USP5 co-localizes to DSBs induced by laser micro-irradiation in a RAD18-dependent manner.
US patients were older and had higher education levels.
U.S. population estimates for older adults born between @number@ and @number@ were generated using age-eligible samples from Waves @number@ and @number@
U.S. prisons are constitutionally required to provide health care to prisoners.
U.S. providers in primary care are interested in learning more about aging sexuality but feel ill-prepared for it.
Usual-break participants significantly increased their body mass index , whereas Booster Break participants maintained body mass index status during the @number@ months.
Usual complications of classic osteosynthesis are numerous , including infections and nonunions and the need for delayed weight bearing after surgery.
Usual dietary intakes were assessed using a semi-quantitative 137-item food frequency questionnaire ( FFQ ) .
Usual diets were assessed by using repeated food-frequency questionnaires.
Usual educational interventions have resulted in limited success in reducing injury.
Usual gait speed ( s ) to walk @number@ meters was stratified by sex and height into quartiles.
Usually , HCMV asymptomatically infects the host during childhood , and establishes life-long latency.
Usually , it is measured by the color-word Stroop test.
Usually , measurement of these factors is performed in a noncentralized manner.
Usually , normal human cell strains are differentiated cells and reach a terminally differentiated state after a number of cell divisions.
Usually , there was \ "no policy , \ " and half of the employers did not support introducing such a policy.
Usually , these fractures are underestimated and treatment is often conservative.
Usual @number@ m gait speed and mobility disability were assessed at baseline and after @number@.2±0.3 years.
Usual walking speed was assessed over @number@ m at baseline and follow-up.
Uterine anomalies were diagnosed by means of hysterosalpingography ( HSG ) and 2D-transvaginal sonography ( TVS ) with intrauterine saline infusion.
Utilities were informed by a meta-regression of @number@ studies.
Utility and validity of these reference labels is demonstrated in a simple atlas-based morphometry approach for automated calculation of HarP-compliant hippocampal volumes within SPM software.
Utility scores were calculated using UK time trade-off utility weights.
Utilization and costs were also examined in descriptive analyses.
Utilization increased consistently in the 9-year study period.
Utilization of additional colonoscopies through to @number@ was ascertained.
Utilization of a specific inhibitor of mineralocorticoid receptors , eplerenone , implicated these receptors as part of the ALD mechanism of action.
Utilization of follow-up colonoscopies performed by the same physician ( @number@ physicians overall ) within @number@ years was ascertained.
Utilizing Asian Working Group for Sarcopenia ( AWGS ) criteria in our population results in a very low prevalence of low SM and low GS.
Utilizing immunoscope analysis , we identified the age-related reduction in TCR-Vβ diversity , but polyclonal pattern was predominant in significantly expanded TCR-Vβ subfamilies.
Utilizing the Health Equity Promotion Model , we examined hypothesized mechanisms accounting for health disparities between bisexual older adults and lesbian and gay older adults.
Utilizing the skills of palliative medicine helps provide reasonable symptom control and QOL without dialysis.
Utilizing UV , IR , NMR , and MS spectroscopic analyses , these chemical structures were revealed.
UTP was determined using the Folin-Ciocalteu assay after solid-phase extraction.
UV absorbance spectra of pooled fresh reflex tear fluid and the ophthalmic solutions were determined.
UVA contributes to the pathogenesis of skin aging by downregulation of procollagen I content and induction of matrix metalloproteinase ( MMP ) -associated responses.
UVA induced disorganization of basal layer , alteration of epidermal development , and fibroblast loss which were alleviated by all nutrient pretreatments.
UVA irradiation also up-regulated the mRNA levels of MMP-1 and TIMP-1 ( P < 0.05 ) .
UVB-induced apoptosis was attenuated after transfection with OGG1.
UVB-induced c-fos and c-jun expressions were also inhibited by the CDP treatment.
UVB-irradiated keratinocytes show higher activity of senescence associated β-galactosidase , less cell proliferation , and reduced viability.
UVB irradiation causes characteristic features of skin aging including remodeling of the dermal extracellular matrix.
UVB wavelengths of light induce the formation of photoproducts in DNA that are potentially mutagenic if not properly removed by the nucleotide excision repair machinery.
UV can penetrate the epidermis and into the mid-dermis , but not into the SC fat tissue of human skin.
UV-cutting intra-ocular lenses were used for patients after surgery.
Uveoscleral outflow slowed ( Fu ; @number@.0±0.2 vs @number@.7±0.1 ) but not significantly.
UV-exposed skin areas ( neck , dorsum of hand or frontier chest ) and UV-unexposed areas ( waist , buttock or abdomen ) were tested.
UV exposure causes immunosuppression via multiple mechanisms in the skin.
UV exposure is known to induce premature aging , which is mediated by matrix metalloproteinase-1 ( MMP-1 ) activity.
UV-induced erythema was consistently present in various grades at caffeine gel , carbomer gel , and control sites.
UV irradiation also activates matrix metalloproteinases ( MMPs ) expression and inactivates collagen synthesis.
UV irradiation and oxidative stress can produce a wide range of DNA damage.
UV irradiation downregulates reactive oxygen species ( ROS ) -elimination pathways , thereby promoting the production of ROS , which are implicated in skin aging.
UV irradiation increases type I collagen degradation through upregulating matrix metalloproteinase ( MMP ) expression.
UV irradiation inhibits type I collagen production by suppressing the TGF-β / Smad signaling pathway and increasing COL1 degradation by inducing MMP-1 expression.
UV irradiation leads to the formation of reactive oxygen species ( ROS ) .
UV is a potent factor in skin photoaging and photocarcinogenesis.
UV light is a well-known factor that causes various types of skin damage and premature aging.
UVL is the main cause of skin cancer and photo-aging.
UVL , through different photochemical modifications forming cyclobutane dimmers , produce mutations to cell phenomenon called neoplasic transformation.
UV radiation decreases type I procollagen production mainly by inhibiting the transforming growth factor-β / Smad signaling pathway.
UV radiation increases the levels of matrix metalloproteinase ( MMP ) @number@ which initiates the cleavage of fibrillar collagen types I and III.
UVR causes DNA damage and genetic mutations , which subsequently lead to skin cancer.
UVR is the major environmental cause of skin aging and UVA-mediated oxidative stress has been associated with the development of wrinkles in humans.
Vaccination coverage was likely to be higher in the countries where normative beliefs in favour of vaccination had formed.
Vaccination is crucially important in preventing infection and protecting vulnerable population from infectious diseases.
Vaccination of high risk subjects with the varicella vaccine seems to be the most effective measure for the prevention of postherpetic neuralgia.
Vaccination of LTC residents and health care workers are reasonable preventive strategies , although most facilities fall short of Healthy People @number@ goals.
Vaccination plus RFB-IAP is more effective and more costly than vaccination alone , and consistently very cost-effective.
Vaccination policies in most high-income countries attempt to reduce the adverse impact of influenza targeting people aged at least @number@ years.
Vaccinations become less effective , and infection with influenza A virus in older individuals is associated with higher morbidity and mortality.
Vaccination should be encouraged in patients at high risk of cardiovascular disease.
Vaccination strategies to prevent varicella or shingles and the current status of antivirals against VZV will be discussed in this chapter.
Vaccine mismatches are frequent because predicting which one will predominate is difficult.
Vaccine plus RFB-IAP prevents @percent@ of cases at a cost of $ 664-2128 / DALY.
Vaccine responses are typically impaired in older individuals.
Vaccine responses were compared using ANOVA , t tests , and Kruskal-Wallis tests.
Vaccines are available for a limited number of these pathogens including influenza , pneumococcal and pertussis vaccines.
Vaccines are powerful public health tools that have been of tremendous benefit in protecting vulnerable populations worldwide from many pathogens.
Vaccines are the most cost effective public health measure for preventing viral infection and limiting epidemic spread within susceptible populations.
Vaccines play a key role in the prevention of illness in the elderly , are cost effective , and generally safe.
VACS scores did not improve the model.
Vacuole frequency increased with donor age but was not influenced by post mortem fixation delays.
Vacuole size varied , and some were confluent.
VAE was found to have antioxidant activity.
Vagal recovery moderated the association between age and EF ( β = @number@ p = @number@ ) .
Vaginal delivery and higher parity increased the risk of both urinary and defecatory symptoms of pelvic floor dysfunction.
Vaginal laxity was assessed by subjective vulvo-vaginal laxity questionnaire ( VVLQ ) .
Vaginal symptoms after menopause are not related to the vaginal cytokine changes associated with loss of estrogen.
VA increased as the HBP level got higher.
Val homozygotes exhibited significantly less cortical activation compared with Met carriers during word processing , particularly at older ages.
Val homozygotes presented steeper negative correlation compared to Met carriers.
Valid and reliable methods to measure nurses ' well-being at work as a positive phenomenon are needed.
Validated and estimated critical intensity were compared by effects sizes , paired-sample t-test and Bland-Altman analysis.
Validated instruments are needed in order to study attitudes toward old people.
Validated in vitro methodologies may reduce the need for extensive testing in animal models.
Validated measures for emotional intelligence , emotional labor strategies , positive affectivity , and employee well-being were administered.
Validated outcome scores were used to assess satisfaction , function , and general well-being.
Validated PA questionnaires were translated and adapted to design the PRISCUS-PAQ.
Validated scales for depression and anxiety , and a single-item question for suicidal ideation were used to assess mental health outcomes.
Validated scales for depression , anxiety , and cognitive impairment were used.
Validated , standardized scales for measurement of ageing and response to cosmetic procedures are lacking.
Validating the usefulness of the fluorescence-enhanced imaging strategy , many known adducts of A2E were identified in the short list of lipofuscin components.
Validation analyses and two multiple comparison correction strategies are provided.
Validation and functional characterization was performed by western blotting , cell-cycle analysis and apoptosis assays.
Validation experiments indicate very good accuracy and generalization capability.
Validation in an additional patient cohort showed that miR-206 and miR-143-3p were increased and miR-374b-5p was decreased compared to controls.
Validation in other series and meta-analytic studies will be important.
Validation of these findings in additional populations may facilitate targeted colorectal cancer prevention strategies.
Validation of the selected subset suggests the approach is appropriate for future investigation.
Validation of the sleep stage detector in other sleep disorders , such as apnea and narcolepsy , should be considered in future work.
Validation tests were conducted to determine the ability of each model to predict survival and conversion to mild cognitive impairment ( MCI ) .
Validation was done with @number@ observers for @number@ cases.
Validation yielded an AUC range of @number@.63-0.64.
Valid ECG assessments at both baseline and last assessment were available for @number@ escitalopram patients and @number@ placebo patients.
Validity and reliability analyses were conducted to test the standards for their accuracy and consistency as predictors of physical independence.
Validity and reliability were evaluated , as well as the factorial structure of the instrument.
Validity evidences based on content were attested by expertise.
Validity evidences based on external variables were positive moderated and BINS ( @number@ m ) / BSID-II ( mental ) presented high correlation.
Validity of the TICS was comparable among non-Hispanic whites , non-Hispanic blacks , and Hispanics.
Validity was assessed by examining IVR-reported falls incidence relative to baseline in-person self-report and performance assessment of balance.
Validity was assessed via a Pearson Product-Moment correlation ( PPM ) between SMBT and EPU maximal vertical force.
Validity was evaluated by testing its association with factors related to frailty and its predictive value for adverse events.
Valid questionnaires from @number@ @number@ ( @percent@ ) eligible individuals ≥ @number@ years of age were included in the study.
Valproate is an important but uncommon cause of drug induced parkinsonism in the elderly.
Value of life was readjusted.
Values above @number@ μg / l were found in @percent@ of all males.
Values of CRP , HDL-cholesterol , triglycerides , GGT , leukocytes and neutrophils were not different between all examined groups of subjects.
Values of each group in both tests were analyzed using one-way-ANOVA and Tukey multiple comparison test.
Values of normalized average closing velocity and speed quotient were higher in children compared to adult men.
Values of PWV and β stiffness parameters increase normally during aging and in certain vascular diseases including atherosclerosis.
Values of risk variables were updated , and the incidence of lens extraction surgery was calculated in each 5-year interval.
Values of these characteristics in patients with Parkinson's disease significantly exceed the values in the corresponding age groups of healthy subjects.
Values of these three dimensions were significantly improved after @number@ weeks of product application , and further improved after @number@ weeks.
Valve regurgitation , especially tricuspid regurgitation ( @percent@ ) , and aortic regurgitation ( @percent@ ) also were common in geriatric rhesus macaques.
Valvular calcification was defined as presence of calcification on the mitral annulus or the aortic valve as determined by echocardiography.
Valvular heart disease is a major cause of morbidity and mortality , and with an aging population , its prevalence is increasing.
Van Gieson elastin stain was completed to assess for elastin fibers.
Vardenafil was well tolerated and adverse events were consistent with the known safety profile of phosphodiesterase type @number@ inhibitors.
Varenicline also showed better outcomes at @number@ and @number@ month follow-up.
Variability based on moderately and highly complex tasks provided the strongest prediction.
Variability during both slow and fast walking was significantly greater compared to comfortable speed walking and was profound in the 7-9 year age group.
Variability in behavioral response to the AS task between participants related to differences in brain function and structure.
Variability in brain regions including a key node of the salience network ( anterior insula ) increased linearly across the lifespan across datasets.
Variability in cognitive declines explained by baseline biomarker values was compared with variability explained by biomarker progression values.
Variability in error and RT mixing cost were associated with RaD in global white matter and in frontoparietal white matter tracts , respectively.
Variability in hippocampal volume in individuals with normal cognition is high.
Variability in normative flow ranges were reduced in distal vessels and by examining regional flows.
Variability in temporal gait factors is another important predictor of mobility function.
Variability of neuronal responses is thought to underlie flexible and optimal brain function.
Variable lipoatrophy and cutis laxa are the basis for a progeroid appearance.
Variables associated with an inverted CD4 : CD8 ratio were older age , nadir CD4 , and detectable HIV viremia.
Variables associated with ' p ' and ' t ' were chosen for multiple regression model investigation.
Variables found to be important in univariate analysis were multivariate model candidates.
Variables from stabilometric platform underwent a principal component analysis.
Variables included age , prescription dose , tumor volume , intracanalicular length , and maximum and mean cochlear dose.
Variables included background and contextual variables , caregiver burden , finding meaning through caregiving ( FMTCG ) , and caregiver physical and mental health.
Variables included blood component type , recipient age and sex , and diagnosis.
Variables independently associated with dizziness were : number of chronic conditions , visual impairment , and use of more than four medications.
Variables of greatest importance at higher ages were low blood pressure and measures related to good cardiorespiratory function.
Variables related to oral health were determined from the radiographs by an oral radiologist.
Variables selected in the development samples were tested in the validation samples.
Variables that best predicted mortality over @number@ years of follow-up were identified using 10-fold cross-validation.
Variables that showed negative correlations with work ability were the following : age , smoking , service time and physical demands in occupational activities.
Variables were analyzed at baseline and during @number@ minutes of isometric exercise.
Variables were assessed bilaterally at baseline and post-intervention.
Variables were categorized according to ICF headings and hierarchical regression analyses were used to predict HUI-Mark III scores.
Variables were compared between LS and non-LS groups.
Variables were reclassified as inferential statistics for analysis by using the independent t-test or Mantel-Haenszel test.
Variables within the domain of Pregnancy and delivery explained the largest proportion of variance in milestone attainment compared to the other domains.
Variables with P < @number@ by univariate analysis were selected for multivariate analysis.
Variables with p < @number@ were considered statistically significant.
Variance measures were used to estimate heritability.
Variance was menstrual age dependent for all parameters except the longest diameter area measurements and their lung-to-head ratios.
Variant-level association testing and gene-based testing were performed.
Variant preoperative , intraoperative and postoperative factors were compared and a scoring system was established to predict the postoperative ascites.
Variants in CD2AP were significantly associated with SAD risk in our subjects.
Variants influencing putamen volume clustered near developmental genes that regulate apoptosis , axon guidance and vesicle transport.
Variants in the AMH , FOXL2 , and GDF9 genes were not associated with timing of menopause.
Variants in the CEL gene / locus were associated with PD in both GWAS and WES analysis.
Variants in the RIC3 gene have recently been suggested as a novel cause of Parkinson's disease ( PD ) .
Variants in the TOM1L2 / SREBF1 locus exert opposing effects TB-LM and TBLH-BMD , and have a stronger association with the former trait.
Variants of sTREM2 carrying AD risk-associated mutations were less potent in both suppressing apoptosis and triggering inflammatory responses.
Variants were centric conventional MOLLI , centric-paired conventional MOLLI , linear 5b ( 3b ) 3b MOLLI and spoiled gradient recalled echo MOLLI.
Variation in body fat distribution contributes to the metabolic sequelae of obesity.
Variation in body iron is associated with or causes diseases , including anaemia and iron overload.
Variation in characteristics of activity spaces may be an underexplored source of differences in health and well-being during later life.
Variation in forward wave amplitude paralleled pulse pressure throughout adulthood.
Variation in household income was not sufficient to account for this association.
Variation in liver availability may not be an \ "accident of geography \ " but rather a byproduct of disadvantage.
Variation in predicted accessibility problems for different type profiles helps identifying priorities in societal planning.
Variation in serum sclerostin is a heritable factor that is determined by both genetic and environmental factors.
Variation in taste receptor genes can give rise to differential perception of sweet , acid and bitter tastes.
Variation in the apolipoprotein E ( APOE ) genotype is associated with cognitive decline in normal aging.
Variation in the apolipoprotein E gene ( APOE ) has been reported to be associated with longevity in humans.
Variation in the miRNA signature in a diseased peripheral circulatory system opens up a new avenue in the field of biomarker discovery.
Variation in the PTH2R gene ( Chr2q34 , rs897083 ) may contribute to the age-associated degenerative manifestations that develop at the lumbar spine.
Variation in TP53 has been associated with cancer.
Variations by time of day , age and gender were explored.
Variations by world region and disease reflect the diverse health care needs of immigrant seniors.
Variations exist in the degree of complexity and cost among different surgical treatments.
Variations in acquisition performance in control participants are related to metabolic activity in the anterior parietal cortex , an area supporting task-positive attentional processes.
Variations in age , gender , and medical comorbidities including diabetes and renal failure create additional complexity that influence the outcomes in septic patients.
Variations in approach and avoidance responses to individual images were also examined , along with age differences in their relationship to memory performance.
Variations in exercise intensity along the age continuum have implications for exercise prescription and composition.
Variations in expectations of filial obligation , length of residence in the U.S. , and self-rated health were significantly associated with these preferences.
Variations in genes other than MTHFR and those directly involved in homocysteine metabolism are associated with CVD risk in non-Hispanic white males.
Variations in L , a , b , c and h were more significant for feldspathic ceramic.
Variations in sex hormones influence bone health in men.
Variations in silent period ( SP ) duration were also examined for certain phases ( APA and EXEC ) .
Variations in socioeconomic , lifestyle , and general health between populations might also have a role.
Variations in spray use by hospital size and region suggest additional targets for future efforts to prevent occupational asthma.
Variations in the hormonal milieu after menopause may influence neural processes concerned with cognition , cognitive aging , and mood , but findings are inconsistent.
Variations in the mtDNA control region were investigated by polymerase chain reaction and Sanger sequencing.
Variations in the overall ethic of care and responsibility based on ethnicity and SES also are discussed.
Variations in treatment response are potentially associated with key male anatomic differences ( e.g. , muscle mass ) .
Varicella-zoster virus ( VZV ) causes chickenpox after which the virus remains latent in neural ganglia.
Varicella-zoster virus ( VZV ) causes two clinically distinct diseases : varicella and herpes zoster.
Varicella-zoster virus ( VZV ) causes two distinct diseases , varicella ( chickenpox ) and shingles ( herpes zoster ) .
Varicose veins and alpha-receptor blockers , nitrates , and benzodiazepines were associated with orthostatic hypotension.
Varieties of transforming growth factor-β ( TGF-β ) antagonists have been developed to intervene with excessive TGF-β signalling activity in cancer.
VAR increased for all conditions , but the interaction effects between treadmill inclination and age , and speed and age were higher for young adults.
Various anatomic measurements of the sacral hiatus , surrounding structures , and sacral canal were performed.
Various aspects of the IVD have long been studied by researchers seeking a better understanding of its dynamics , aging , and subsequent disorders.
Various assays for PAPP-A exist and the type of assay used in a study should be considered.
Various biological and genetic markers also have prognostic value.
Various cardiac imaging parameters , including absolute scar size , were compared at baseline and @number@ year post-TESI.
Various causes of neuromotor decline , including both peripheral and central neurological deficits , have been hypothesized.
Various cell systems , e.g. defense mechanisms against reactive oxygen radicals ( ROS ) , DNA repair and apoptosis are regulated by microRNAs.
Various chronic clinical conditions are characterized by membrane damage , mainly oxidative but also enzymatic , resulting in loss of cellular function.
Various clinical tools can help the physician to assess and restore androgen levels in men with ED.
Various cognitive domains were assessed before and after the intervention.
Various cognitive tendencies correlated with the metacognition of phenomenal experience.
Various correlates were independently associated with frailty status.
Various cosmetic treatments including topical retinoids , growth factors , and skin lighteners have shown some benefit.
Various dementia care models have been developed to address patient's healthcare needs.
Various diagnostic methods are being developed to discriminate disease from nondisease and track progression.
Various dietary supplements are claimed to have cutaneous anti-aging properties ; however , there are a limited number of research studies supporting these claims.
Various different definitions of MUI , ranging from low to high threshold , were created using a combination of these baseline incontinence measures.
Various different surgical techniques are also presented , together with results and complications.
Various early forms of misfolded α-Syn oligomers are cytotoxic.
Various environmental factors , such as oxidative stress and inflammation , can accelerate telomere shortening.
Various environmental stresses-induced excessive production of ROS triggers cellular senescence and abnormal differentiation on MSCs.
Various factors are assumed to account for this paradox , yet empirical evidence on this issue is scarce.
Various factors are involved , including low adult SES , psychological distress , and unhealthy lifestyles.
Various factors can contribute to all the discrepancies.
Various features were extracted using the Sigma-Lognormal model on @number@ stereotypical triangular movements performed by @number@ subjects having different health conditions.
Various global cut-off scores were also analyzed.
Various healthcare providers around the world have adopted similar models of care to manage changing healthcare needs.
Various intermediary markers that may predict disease outcome have been used as functional criteria in the DRI process.
Various internal and external methods have been described for the removal of the buried bumper.
Various interventions , including medication reviews , to optimize pharmacotherapy in older people residing in aged care facilities have been described and evaluated.
Various interventions to improve drug prescribing such as educational approaches , geriatric medicine services , computerised prescribing and multifaceted approaches have also been highlighted.
Various issues related to general population aging are posing serious problems , which require prompt resolution.
Various manipulations have been shown to interfere with the ageing process.
Various measures of biological aging have been proposed.
Various mechanisms including hypoxia and increased production of reactive oxygen species ( ROS ) are implicated in the etiology of WML.
Various mechanisms in the mammalian body provide resilience against food deprivation and dietary stress.
Various memory assessment tests were carried out on individuals at baseline and during follow-up investigations , and biallelic genotyping was performed.
Various mutations in the SLC39A4 gene ( ZIP4 ) , which encodes a zinc transporter , are responsible for this disorder.
Various neurodegenerative disorders share some clinical features that sometimes renders differential diagnosis challenging.
Various observational-behavioural pain assessment instruments have been reported to be both reliable and valid in individuals with dementia.
Various parameters were recorded at admission , at the initiation of intake , and during hospitalization ; these parameters were statistically evaluated.
Various physiologic , anatomic , and motivational considerations differentiate the treatments for male and female patients.
Various practical implications of this research emerge for the development of future recreational programs in nursing homes to promote seniors ' adaptation.
Various problems accompany it since aging makes the elderly undergo a decline in their natural functions.
Various programs or structured interventions have been developed to prevent or lessen these negative consequences.
Various properties and performance of the proposed kernel regression framework are demonstrated.
Various protein factors , including telomerase and WRN helicase , are involved in telomere maintenance.
Various QT-correction equations were fitted to the individual QT-RR data to evaluate the most appropriate equation.
Various reaction of lymphocytes on a pneumonia in men and women of young and middle age was revealed.
Various risk factors are demonstrated to be responsible for its pathogenesis , such as aging , light exposure , and smoking.
Various sociodemographic and health-related characteristics were correlated with medical conditions.
Various source-derived mesenchymal stem cells ( MSCs ) have been considered for cell therapeutics in incurable diseases.
Various stem cells including cells from embryo , fetus , perinatal , and adult tissues have proved effective in preclinical and small clinical trials.
Various stimuli can alter skin integrity.
Various strategies , especially controlling hypertension , show benefit in preventing , delaying or attenuating vascular aging.
Various structurally diverse stimulators activate the NLRP3 inflammasome through different signaling pathways.
Various synonyms are used to cover aging well , such as active aging.
Various techniques are now widely available to allow the detailed examination of reproductive hazards using only minor samples of genetic material.
Various techniques in harvesting , processing , and injecting autologous fat have been debated at length without clear guidelines emerging to maximize outcomes.
Various techniques of peelings : superficial , medium , deep , combined and mosaïc peel will be detailed.
Various testosterone formulations exist , differing in route and frequency of administration as well as in side-effect profiles.
Various tests have been developed.
Various tissues in the human body , including cartilage , are known to calcify with aging.
Various types of urinary stones have been described upon their mineral content and / or their morphology.
Varivax® , a live-attenuated vaccine , is available for pediatric varicella.
Varying costs and effect estimations revealed that the results of the primary analyses were robust.
Varying forms of social support played different moderating roles in depressive symptomatology among older adults with MCC.
Varying postoperative and functional outcomes have been reported but differences in study population , management approaches and endpoints may account for these variations.
Varying prevalence , specificity , and sensitivity numbers indicate the need for further research.
Varying the cost assumptions did not change cost-effectiveness.
Varying the number of events did not affect the pattern of the gradient.
VAS and the satisfaction score were much better in patients < 16 years group compared with ≥ @number@ years group at last follow-up.
Vascular aging , as assessed by structural and functional arterial properties , is an independent predictor of cardiovascular risk.
Vascular aging consists of complex and multifaceted processes that may be influenced by genetic polymorphisms of the renin-angiotensin system.
Vascular aging is accelerated by coexisting cardiovascular risk factors , such as hypertension , metabolic syndrome and diabetes.
Vascular aging is a chronic process , and many negative effects of obesity in this process have been well defined.
Vascular aging may be responsible for the high residual lifetime risk for hypertension in the middle-aged and elderly individuals.
Vascular aging-related hypertension is expected to become the dominant phenotype in many countries , especially in the Asian regions.
Vascular amylin deposition provokes loss of endothelial cell coverage and tight junctions.
Vascular anatomy should be taken into account when selecting patients for stenting.
Vascular and autonomic function were examined.
Vascular and inflammatory factors influenced the association between BMI and FA.
Vascular and neurodegenerative disease commonly cooccur in older persons.
Vascular assessment included carotid intima-media thickness and carotid distensibility using B-mode ultrasound and central and peripheral pulse wave velocities using applanation tonometry.
Vascular brain lesions and brain volume did not mediate the relationship between iron and cognitive performance.
Vascular calcification has become an important predictor of cardiovascular disease.
Vascular calcification has severe clinical consequences and is considered an accurate predictor of future adverse cardiovascular events.
Vascular calcification increasingly afflicts our aging , dysmetabolic population.
Vascular calcification is a complication that also occurs during aging , in particular in association with atherosclerosis and T2DM.
Vascular calcification is a major risk factor for cardiovascular morbidity and mortality.
Vascular calcification is a pathologic phenomenon in which calcium phosphate is ectopically deposited in the arteries.
Vascular calcification is common in aging and also in a number of genetic and metabolic disorders.
Vascular calcification is commonly seen in elderly people , though it can also appear in middle-aged subjects affected by premature vascular aging.
Vascular calcification is prevalent in patients with chronic kidney disease and leads to increased cardiovascular morbidity and mortality.
Vascular calcification refers to the deposition of calcium phosphate mineral , most often hydroxyapatite , in arteries.
Vascular calcification represents the deposition of calcium phosphate salts in the tunica media of the vascular wall.
Vascular calcifications and bone health seem to be etiologically linked via common risk factors such as aging and subclinical chronic inflammation.
Vascular cell senescence is observed in experimental and human cardiovascular pathologies.
Vascular changes related to obesity may begin in adolescence , as illustrated by the increased PWV.
Vascular circulation , pulse wave velocity , cardiac and vascular calcifications , and vascular functional properties were estimated.
Vascular complications with necrosis and ulceration were rare.
Vascular dementia and AIDS dementia are secondary dementias.
Vascular dementia and Alzheimer's disease share several risk factors and are nowadays considered two ends of a continuum rather than two distinct entities.
Vascular dementia had been previously diagnosed in @percent@ of participants , Alzheimer's disease in @percent@ and mixed forms in @percent@.
Vascular disease is one of the leading causes of death worldwide.
Vascular diseases affect not only the patient , but also place burdens on their spouses , families , friends , and communities.
Vascular diseases are the leading cause of preventable death and disability in Canada.
Vascular dysfunction is caused by : ( @number@ ) Oxidative stress enhancement.
Vascular endothelial cell adiponectin was not related with circulating adiponectin ( r = @number@ P = @number@ ) .
Vascular endothelial cells cultured in vitro are widely used , however , isolating pure vascular murine endothelial cells is technically challenging.
Vascular endothelial growth factor and erythropoietin serum protein assays were conducted using the Meso Scale Discovery platform.
Vascular endothelial growth factor A ( VEGF ) , a key factor in angiogenesis , plays an essential role in skeletal development and postnatal homeostasis.
Vascular endothelial growth factor interacted with β-amyloid @number@ in predicting longitudinal memory decline ( t1618 = @number@ P = @number@ ) .
Vascular endothelial growth factor ( VEGF ) has been characterized as a heparin binding angiogenic growth factor displaying high specificity for endothelial cells.
Vascular endothelial growth factor ( VEGF ) has been implicated in staving off AD-related neurodegeneration.
Vascular endothelial growth factor ( VEGF ) was originally recognized as a substance predominantly with vascular permeability and angiogenesis.
Vascular factors and AD pathology are not independent but rather appear to interact.
Vascular flow disturbances were quantified using a parametric model and mapped to the mid-cortical surface for group-wise statistical analysis.
Vascular function was significantly impaired in 12-month-old GPx-1 ( - / - ) -mice as compared with age-matched controls.
Vascular glycosaminoglycans contribute to the non-thrombogenic activity of blood vessels.
Vascular health requires partnerships for action across many sectors including government , health care practitioners , academia , not-for-profit organizations , and the private sector.
Vascular inflammation , and overproduction of inflammatory cytokines , growth factors and aberrant endothelial cell migration , initiate defective blood vessel proliferation in exudative AMD.
Vascularization is fundamental for bone formation and bone tissue homeostasis.
Vascular maintenance attributed by circulating CD34-positive cells is thought to be a background mechanism of this association after hypertension-induced vascular injury in skeletal muscle.
Vascular maintenance depends on angiogenic balance in tissues.
Vascular pathology was quantified using a previously reported macrovascular lesion ( MVL ) score.
Vascular properties were compared between patients above and below @number@ years of age.
Vascular pruning , the removal of aberrant neovessels by apoptosis , is a vital step in this process.
Vascular-related MCI ( MCI-CVD and MCI-VRF ) was most common.
Vascular repair , essential for tissue maintenance , is critically reduced during vascular disease and aging.
Vascular responses to acetylcholine ( ACh ) and sodium nitroprusside ( SNP ) were measured by isolated vascular perfusion.
Vascular risk does not exist in isolation , and is accompanied by alterations in hormonal metabolism and metabolic syndromes.
Vascular risk factors and alcohol abuse may also predispose to their occurrence.
Vascular risk factors and alcohol abuse were more observed in the seizure patients.
Vascular risk factors and depressive symptoms did not have any effect modifier on the relationship between reversible cognitive frailty and incident dementia and all-cause mortality.
Vascular risk factors and vascular / inflammatory blood markers were assessed.
Vascular risk factors may increase the risk of functional impairment due to clinical and subclinical vascular disease.
Vascular risk factors may represent a therapeutic target , while neurodegenerative pathologies have not yet been amenable to treatment.
Vascular smooth muscle cells ( SMCs ) can resist and repair artery damage , but their capacities decline with age and stress.
Vascular smooth muscle cells ( VSMCs ) are an integral part of atherosclerotic plaque formation , progression and subsequent rupture.
Vascular sprouting was comparable between choroid samples obtained from different animals of the same genetic background.
Vascular stiffness is a mechanical property of the vessel wall that affects blood pressure , permeability , and inflammation.
Vascular stiffness is regarded as a result of degenerative processes potentiated by aging , hypertension , and other risk factors.
VASH1 is expressed mainly in endothelial cells to inhibit angiogenesis , whereas VASH2 is expressed mainly in cancer cells to stimulate tumor growth.
Vasoconstriction increases the degree of bubble formation which is believed to be the cause of DCS.
Vasoconstriction is an underlying mechanism associated with all of these risk factors.
Vasodilatation to ACh was lower ( approx.
Vasodilation test protocols should take into account the age of the subjects.
Vasodilation thresholds were similar between groups ( P > @number@ ) .
Vasohibin 1 / CD34 could identify the proliferative vessels and could be a useful biomarker for predicting the clinical outcome of HCC patients.
Vasohibin-1 ( VASH1 ) is isolated as an endogenous angiogenesis inhibitor produced by the vascular endothelium.
Vasohibin-2 is mainly expressed in cancer cells , and has been implicated in the progression of cancer by inducing angiogenesis and tumor growth.
Vasohibin-2 ( VASH2 ) is a homolog of VASH1 , an endothelium-derived angiogenesis inhibitor.
Vasohibin-2 ( VASH2 ) is a homolog of vasohibin-1 and exhibits pro-angiogenic activity.
Vasohibins ( VASH1 and VASH2 ) are recently identified regulators of angiogenesis and cancer cell functions.
Vasomotion ( rhythmic changes in arteriolar diameter ) is believed to enhance tissue perfusion at low oxygenation levels.
Vasomotor symptoms ( VMS ) are recognized to adversely affect the quality of life.
Vasoreactivity was the slope of the regression between cerebral perfusion and end-tidal CO ( @number@ ) .
Vastus lateralis muscle biopsy samples were obtained before and @number@ hours after the intervention.
VAT and SAT macrophage markers did not correlate.
VAT correlated weakly with fat mass indicators ( r = 0. @date@ ) .
V ( avg ) increased ( P < @number@ ) , as did voids / L intake ( P = @number@ ) .
VBF was compared to no intervention , a placebo , and traditional exercise.
VBM analysis showed regions of decreased GM volume in right and left hippocampus and within more lateral temporal areas in patients with OSA.
VBM showed that GM volumes were indistinguishable between groups but significant age effects were apparent , independent of diagnosis.
VBQ of white matter revealed distinct anatomical patterns of age-related change in microstructure.
VCI was defined by impairment in any cognitive domain on neuropsychological testing.
VDAC is thus involved in the choice the cells make to survive or die , which is particularly relevant to cancer cells.
VEDS dermal fibroblasts secreted more TGF-β2 , whereas downstream canonical / noncanonical TGF-β signaling was not different.
Vegetable intake was also significantly associated with lower dental caries score.
Vegetable peptones significantly promoted cell proliferation in a concentration-dependent manner.
Vegetables , vitamin C intake and serum ferritin were positively associated with ORAC , whereas saturated fatty acids and meat intake were negatively associated.
VEGF-165 protein therapy was able to induce in vitro and in vivo angiogenesis during aging.
VEGF expression is lost once NSCs commit to a neuronal fate , but Flk-1-mediated sensitivity to VEGF signaling is maintained.
VEGF inhibitors are a current pharmacological tumoral strategy.
VEGF serves as a survival factor for chondrocytes and couples the resorption of cartilage with bone formation during endochondral ossification.
VEGF₁₈₉ was also upregulated in human RPE challenged with peroxide , hypoxia , or cultured in contact with CECs.
Vehicle affected neither the atrial effective refractory period nor AF duration.
Velocity and spatial , temporal , and variability gait parameters were recorded using an instrumented walkway.
Velocity ( cm / s ) measured quantitatively during NW and WWT conditions.
Velocity ( cm / s ) was obtained using an instrumented walkway.
Velzke in the paper that follows this introduction discusses why it is important and how to include older adults as participants in research.
VEMP latency , amplitude , asymmetry ratios , and prevalence of absent responses were compared across demographic and cardiovascular risk groups.
VEMP P1 and N1 latency , threshold , peak-to-peak amplitude , and interamplitude difference ( IAD ) ratios were obtained at @number@ dB SPL.
Venepuncture and cannulation are the most commonly performed invasive procedures in health care today.
VENNTURE enabled the delineation of highly complex patterns of dose-dependent G protein-coupled receptor activity and its dependence on physiological cellular contexts.
VENNTURE was able to reliably and simply dissect six complex data sets into easily identifiable groups for straightforward analysis and data output.
Venous blood samples were collected before and immediately after these exercises.
Venous blood samples were collected @number@ min before and @number@ min after exercise.
Venous blood samples were collected prior to , and @number@ h following ingestion.
Venous blood specimens were collected at baseline , @number@ @number@ @number@ and @number@ min after ingestion and the plasma Zn was measured for each sample.
Venous blood was drawn from children aged 12-35 months to evaluate micronutrient status.
Venous blood was sampled at ∼20-minute intervals on both nights.
Venous occlusion at the wrist ( @number@ ± @number@ mmHg ) and moisturizer were used to alter skin mechanics.
Venous thromboembolism ( VTE ) has recently increased owing to the westernization of our food habits and an aging society in Japan.
Venous thromboembolism ( VTE ) occurs more frequently in older people.
Venous thrombosis ( VT ) is the third most common cause of cardiovascular death worldwide.
Venticuloperitoneal shunt was done before correction of FMEC in one patient ( @percent@ ) .
Ventilatory threshold was assessed during an incremental cycling test.
Ventral DMN subnetworks may have more functional connections in ADHD-I , while dorsal DMN may have less.
Ventricular dilation increases in severity over time , becoming fatal at 4-8 weeks of age.
Ventricular dysfunction is frequently encountered in Fontan patients.
Ventricular expansion in MCI was associated with thinner gray matter in frontal , temporal , and parietal regions affected by AD.
Ventricular expansion reflects cortical atrophy in early AD , offering a useful biomarker for clinical trials of interventions to slow AD progression.
Ventricular fibrosis seems to contribute to abnormalities in cardiac relaxation and contractility and to the development of heart failure , a common finding in AF.
Ventricular measures can represent accumulation of diffuse brain atrophy with very high effect sizes.
VEP responses of @number@ colour deficient children were compared to @number@ children with normal colour vision.
VEPs were acquired before ( @number@ ± @number@ days ) and after cataract surgery ( @number@ ± @number@ days ) .
Verapamil , a calcium channel blocker , has been shown to be an effective IA adjunct in a pre-clinical mouse focal ischemia model.
Verbal communication in a \ "cocktail-party situation \ " is a major challenge for the auditory system.
Verbal episodic memory impairment in schizophrenia may share common mechanisms with similar impairment in healthy aging.
Verbal fluency , information processing speed , learning , and memory were tested in Spanish or English.
Verbal fluency task ( VFT ) is widely used as a neuropsychological test of frontal lobe function.
Verbal fluency was not affected by APOE E4 status.
Verbal information is better retained when it is self-generated rather than when it is received passively.
Verbal instructions and visual feedback referring to different percentages of weight-bearing distribution to execute were used to quantify weight-bearing perception in sit-to-stand tasks.
Verbalizations were detrimental for young adults , beneficial for older adults , and had mixed effects in children.
Verbal learning and recall scores were worse in those with left than right HS.
Verbal memory , letter search speed and reaction time were assessed at age 60-64 years.
Verbal transformations are illusory changes that arise from listening to a spoken word repeated over and over for a prolonged period of time.
Verbal working memory , semantic knowledge and memory and word-finding ability are also involved in performing analogies.
Verbal working memory was significantly more impaired in schizophrenia patients than in the healthy elderly.
Verbatim transcriptions were independently analyzed line-by-line by two coders using an inductive approach.
Verbatim transcripts were analysed for themes , which were independently verified.
Verbatim transcripts were analyzed using interpretative phenomenological analysis.
Vergence eye movements and dissociated phoria were recorded from @number@ healthy subjects ( ages 20-70years ) using an objective eye movement tracking system.
Verhoeff-Van Gieson staining showed numerous elastic laminae in the tunica media.
Vericiguat is currently being studied in a Phase III clinical program for the treatment of heart failure with reduced ejection fraction ( HFrEF ) .
Veridical recollection was impaired in old age in all memory conditions.
Vernakalant blocks atrial-specific potassium and sodium ion channels , prolonging atrial refractory periods and rate-dependently slowing atrial conduction , without promoting ventricular arrhythmia.
Vernakalant was generally well tolerated in clinical trials , with most adverse events being of mild or moderate severity and not treatment limiting.
Verrucae seborrhoica , keratosis actinica and mycoses are more common then in general population.
Verrucomicrobia and sleep quality were not associated with Stroop Word performance independent of one another.
Versatile glycoblotting nanoparticles for high-throughput protein glycomics.
Versican stain was increased in male aged skin , but not in female.
Versus tamsulosin , peak urine flow and QoL improved equally well versus finasteride.
Vertebra height increases were associated with disc narrowing ( p = .001 ) .
Vertebral and hip fractures lead to increased morbidity and mortality and result in enormous healthcare costs.
Vertebral body fractures were more frequent in the atrophic type than in the other types.
Vertebral body fracture was more frequent in the atrophic type , suggesting the involvement of osteoporosis at the onset of hip osteoarthritis.
Vertebral fractures and abdominal aortic calcifications ( expressed as calcium score ) were also assessed.
Vertebral osteophytes were found to be effective in stabilizing the spine in bending motions.
Vertebrate skeletal muscle fibers have two traits that make them unique : the fibers are multinucleated and their nuclei are post-mitotic.
Verteporfin is a benzoporphyrin derivative used clinically in photodynamic therapy to treat macular degeneration.
Verteporfin was recently found to inhibit autophagosome formation by an unknown mechanism that does not require exposure to light.
Vertical allometry was initially reported for diazepam based on a 33-fold higher human predicted clearance than the observed human clearance.
Vertical bands , horizontal lines , and loss of lower face contour are effectively treated with botulinum toxin A ( BoNT-A ) .
Vertical ( BV.vert / TV ) and horizontal ( BV.horz / TV ) bone volume fraction decreased significantly with age for both sexes.
Vertical ground reaction forces were measured using a forceplate , and the number and latency of postural adjustments were quantified.
Vertical intervals ( VIs ) were then calculated as the parameter for the height of the articular surface.
Vertigo , unsteadiness , and other balance-related symptoms are common among older adults.
Very elderly patients were propensity matched with younger patients ( 1 : 2 ratio ) , and the analysis repeated.
Very few articles dealt specifically with the frail older person.
Very few human genes can be used to identify spontaneous inactivating somatic mutations.
Very few ( @number@ of @number@ @percent@ ) common variant associations were fully explained by low-frequency variants.
Very few patients noticed or complained about eyelid changes.
Very few people had Sirtuin @number@ levels of over @number@ pg BDORT units in most parts of the body.
Very few studies ask drinkers why they change their consumption in later life.
Very few studies have investigated mental health in sub-Saharan Africa ( SSA ) .
Very few studies have used longitudinal data to examine whether age variations in the sense of control are due to ageing effects or cohort differences.
Very few studies specifically evaluated the outcome of obesity treatment in the aging patients.
Very few transitional blue discolorations ( @percent@ ) were observed.
Very high effect sizes for the ICG , BDI and IES-R reflect the effectiveness of the intervention along the longitudinal profile.
Very high hyper-methylation was observed in the aged group within the INK4A / ARF / INK4b locus and this was validated by pyrosequencing.
Very important in this period are health behaviors , including healthy lifestyle , regular exercises and proper diet.
Very late stent thrombosis is defined as in-stent thrombosis occurring after @number@ year of an intra-coronary artery stent placement.
Very limited information is available in patients or related donors @number@ years of age and older.
Very little attention has been given to the combined effects of aging and disuse as separate factors causing deterioration in muscle mechanical function.
Very little is known about the relation between these lifestyle activities and cognitive function in young adults.
Very little is known on the effect of tomato industrial processing on antiaggregatory activity and phenolic profile.
Very little is understood about the attentional demands of stair descent and their changes with aging.
Very little rigorous research has been conducted on reducing inappropriate medications in patients approaching end of life.
Very low blood pressure and orthostatic hypotension are associated with increased mortality , and should be checked for at every visit.
Very low food security was associated with being born in Mexico , adjusting for household income and food assistance program participation.
Very old MCI subjects showed a significantly greater impairment than younger MCI patients in cognitive domains involving executive functions.
Very young mammals have an impressive cardiac regeneration capacity.
VES-13 is a @number@ items tool that explores prevalently the functional status and the self reported health status.
Vesicular uptake is also markedly decreased in the heart in PD.
Vestibular causes of dizziness contribute to a multifactorial geriatric syndrome.
Veteran hospital administrators have many years of experience and can offer a wide array of skills and competencies to their organization.
Veterans also completed the 2-item Patient Health Questionnaire ( PHQ-2 ) , a validated depression screening instrument frequently used in primary care settings.
Veterans are randomized to nurse telephone support or usual care.
Veterans were followed from first clinical encounter on / after @date@ , until AMI / death / last follow-up date ( @date@ ) .
Veterans with HIV may have different rates of Medicare and Medicaid enrollment and may be at greater risk of poor outcomes related to non-VA use.
Veterinarians and their v-teams must overcome this insensitive attitude about life-limiting disease.
VETSA produced the first comprehensive assessment of the heritability of cortical and subcortical brain structure sizes , all within the same individuals.
V ( E ) was also decreased ( @number@.81±0.16 vs. @number@.65±0.11 mm Hg / % , P < 0.001 ) after NTG.
VFA was measured by single slice abdominal computed tomography scanning.
VFx prevalence was associated with sc- @time@ and TBS independently of each other and of other risk factors.
VGF-expression by NK cells was age-independent.
VGF is a protein expressed by neurons and processed into several peptides.
VGLUT2 expression remained unaltered in all conditions.
VGs could also be used at home to maintain rehabilitation benefits.
VHI scores varied greatly , ranging from @number@ to @number@ with an average score of @number@
VHIT was analyzed for percentage of covert saccades and for cumulative overt saccade amplitude.
VHL deletion in the pancreatic β-cells led to impaired glucose tolerance due to defects in glucose-stimulated insulin secretion and β-cell mass with age.
VHL-knockout islets had decreased GLUT2 , but increased glucose transporter @number@ and vascular endothelial growth factor expression.
Viability assay demonstrated that CK2 inhibitors facilitated TNF-α-mediated chondrocyte death.
Viability of transplanted fat is a main consideration when fat grafting is performed.
Viable osteocytes may sustain a life-long anti-resorptive signaling pathway for inner ear OPG.
Via mass spectrometry , we found that 60S-associated , but not , polysome-associated , RPL24 undergoes HDACi-induced acetylation on K27.
Vibration biomechanical stimulation as the physiological basis of vibration physical exercises ( whole body vibration ) causes reflecting muscle contractions like tonic vibration reflex.
Vibration therapy is designed to be a nonpharmacological analogue of physical activity , with an intention to promote bone and muscle strength.
Vibratory sensation thresholds remained relatively stable within and across study days.
Vibrotactile feedback ( VTF ) has been shown to improve balance performance in healthy people and people with vestibular disorders in a single-task experimental condition.
Vice versa , overexpression of RONS producing enzymes as well as deletion of antioxidant enzymes was demonstrated to aggravate cardiovascular complications.
VIDEO ABSTRACT.
VIDEO ABSTRACT : A leaky blood-brain barrier has long been implicated in cognitive dysfunction in aging and neurodegeneration , but reliable human data were lacking.
VIDEO ABSTRACT : @url@
Video-assisted thoracic surgery was performed in @number@ cases ( @percent@ ) .
Video-based methods and video equipment are being applied to assist qualitative and simple quantitative analysis for immediate feedback and research in swimming.
Video capture and secure transmission of real-world falls thus stands as a promising assistive tool.
Video decision support is a practical approach to improve advance care planning.
Video decision support tools improved advance care planning in small randomized controlled trials.
Video endoscopy equipment company \ "OLYMPUS \ " ( Japan ) , morphological methods and the determination of Helicobacter pylori ( Hp ) were used.
Videofluoroscopic swallow studies were performed on @number@ normal adults.
Video gamed-based interventions may also alleviate mood or behavioral disorders , and increase interactions with friends , family , caregivers or other patients.
Video gaming has been shown to improve functional outcomes.
Video gaming is becoming an increasingly popular adjunct to traditional therapy.
Video gaming is most commonly used by physical therapists in a hospital setting for those with balance impairments.
Video replay enabled identifying cognitive-behavioral deficiencies and environmental circumstances contributing to the fall.
Video review enabled screening for the severity of falls and fall-related injuries.
Video review was provided to facility staff , thanks to a customized mobile device app.
Videos of the focus groups were recorded and analysed using mind mapping techniques.
Video Status Reports in facilities ' electronic medical records permitted \ "real-time \ " adherence monitoring and corrective actions.
Vietnamese and Filipinos tended to have poorer physical health than Chinese , Japanese , and Koreans.
Vietnam War veterans are a sometimes overlooked subgroup of the aging baby boomer generation.
Viewing observed and estimated survival separately , observed survival past sixty increased over the years considered.
Viewing positive and negative pictures from the International Affective Picture System had opposite effects on startle modulation for older and younger adults.
Views on ageing are a promising intervention technique to be incorporated into future physical activity interventions for older adults.
Views on aging and attitudes toward own aging were assessed with questionnaires.
Views on aging have been shown to predict the occurrence of events related to physical health in previous studies.
Views on functional adaptation in chronic alcoholism have expanded with results from neuroimaging studies.
Vigorous physical activity during the week was noted in only @number@ seniors.
Vigorous physical activity seems to promote healthy ageing and should be encouraged when safe and feasible.
Village doctors felt that it was difficult to provide all the required public health services.
Villanova University College of Nursing does not require submission of your answers to the quiz.
Villanova University College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.
Vinblastine treatment was also used to halt autophagy and further characterize changes and provide additional insight on the nature of autophagy organelles.
Viral clearance in CHC patients pan-genotypically restored fuel utilization by decelerating the tricarboxylic acid cycle.
Viral mediated atherogenesis further accelerates end organ dysfunction and increases mortality.
Viral proteins that circulate in blood can induce brain endothelial cells to release cytokines , invoking another source of neuroinflammation.
Viral studies were performed on @number@ URI episodes ; @percent@ were positive.
Virchow's triad describes the three main factors of thrombus formation to be stasis of blood flow , endothelial injury and hypercoagulability.
Virchow's triad is then used as a framework for discussion to approach the question posed regarding the link between venous valvular stasis-associated hypoxia and thrombosis.
Virol.
Virologic suppression was maintained at @percent@ of follow-up visits.
VirtualDose agrees with the size-based methods within @percent@ difference for the organs investigated.
Virtually all DEVILs were acid-phosphatase reactive but contained p62 immunoreactivity and periodic acid-Schiff stained plaques.
Virtually all immune cells studied show a combination of an activated status and loss of function.
Virtually all studies on cosmeceuticals have been performed in women with varying degrees of skin aging.
Virtual reality computer-based technology that provides the user with opportunities to interact with virtual objects is used extensively for entertainment.
Virtual reality ( VR ) incorporates principles of motor learning while delivering engaging and challenging training in complex environments.
Virtual reality ( VR ) using immersion and interaction may provide new approaches to the treatment of memory deficits in elderly individuals.
Virtual turning preference correlated with volumetric asymmetry in the striatum , cerebellum , and hippocampus but not in the prefrontal cortex.
Viruses exacerbate COPD and bacteria may play a part in severe COPD ; therefore , antibiotic and antiviral approaches have a sound rationale.
Visante-OCT demonstrated highest values of three devices regarding to ACD followed by Lenstar LS900 and IOLMaster.
Visceral adipose tissue ( @number@ ± @number@ g visceral fat per patient ) was processed with type-1 collagenase to obtain ADSCs from the stromal-vascular fraction.
Visceral adiposity measured by computed tomography ( CT ) has consistently been shown to have negative effects on bone.
Visceral fat , abdominal and thigh subcutaneous fat , and thigh muscle were assessed by computed tomography.
Visceral fat accumulation is associated with atherosclerosis and metabolic syndrome , but peripheral subcutaneous ( SC ) fat accumulation may be protective.
Visceral fat and BAT masses increased in PGKmutBP3 mice , but not in PGKBP3 mice.
Visceral fat mass decreased ( p < @number@ ) with training.
Visceral leishmaniasis ( VL ) is among the seven global endemic diseases assigned a high priority by the World Health Organization.
Visceral WAT IGFBP2 expression was significantly associated with IGFBP2 circulating levels in mice , suggesting an important contribution from this tissue.
Visceral WAT typically shows greater macrophage infiltration.
Viscolin , an extract of Viscum coloratum , has anti-inflammatory and anti-proliferative properties against harmful stimuli.
Viscosity and pH data were evaluated almost simultaneously at six different times after sampling in order to identify any variations due to aging.
Viscosity and pH were measured at a temperature of @number@ °C in a thermostatic bath.
Viscosity decreased exponentially as a function of time after sampling then reaching a plateau around @number@ cSt , while the pH values increased linearly.
Viscosity is another mechanical characteristic of the arterial wall ; however , the effects of age and cardiorespiratory fitness have not been determined.
Visfatin also participates in several pathophysiological processes contributing to cardio-cerebro-vascular diseases , including hypertension , atherosclerosis , ischemic heart disease , and ischemic stroke.
Visfatin is the first identified growth factor derived from PVAT.
ViSiBooL aims at providing a graphical way of modeling and simulating networks.
Visinin-like protein @number@ ( VILIP-1 ) has demonstrated potential usefulness as a marker of neuronal injury in AD.
Vision and audition provide spatial information about the environment to guide natural behavior.
Vision and cognition scores were unrelated ( Pearson = -0.09 , p = 0.41 ) .
Vision assessment and provision of new spectacles may not reduce , and may even increase , the risk of falls.
Vision function and vision-related quality of life scores were assessed in those who received and did not receive surgery.
Vision impairment and memory limitations were also associated with lower likelihood of technology use.
Vision-related quality of life was assessed using a standardized questionnaire and Rasch transformation.14 , 696 people were included.
Vision research has often led to significant advances in our understanding of biology.
Vision research supports dual-learning systems that are grounded in neuroscience and are partially dissociable.
Vision screenings should focus on targeting populations that exhibit these risk factors.
Vision-threatening diabetic retinopathy ( VTDR ) was defined as the presence of a clinically significant macular edema ( CSME ) or proliferative diabetic retinopathy.
Vision was assessed with self-report and measured distance visual acuity.
Vision was measured at distance , near , and by self-report in the NHANES and by self-report alone in the NHATS.
Visiting Mars can wait.
Visit-to-visit variability in blood pressure was defined as the standard deviation of blood pressure measurements between visits.
Visual acuities with the monofocal IOL were not associated with patient age.
Visual acuity alone , or in combination with auditory acuity , did not contribute to any acceptable SEM solution.
Visual acuity and ocular pressure did not change.
Visual acuity losses with cataract and other media opacities are not due to straylight , but caused by aberrations and micro-aberrations.
Visual acuity , low luminance acuity , spatial contrast sensitivity and macular light sensitivity did not differ between normal eyes and early AMD eyes.
Visual acuity was 20 / 32 in her left eye and 20 / 20 in her right eye.
Visual acuity was assessed and the condition of the lens and posterior pole examined by direct ophthalmoscopy.
Visual acuity was inversely related to age only in agrarians ( r = @number@ P < @number@ ) .
Visual analysis of real-life scenes starts with the parallel extraction of different visual elementary features at different spatial frequencies.
Visual and postural coordination may be affected by aging which is associated with a decline in sensory and motor functions.
Visual and vestibular support appear insufficient for postural stability control in the idiopathic gait disturbance group.
Visual assessment of buccal cell CK14 expression was carried out using immunofluorescence techniques.
Visual assessments and semiquantitative evaluations of binding potentials ( BPs ) were used.
Visual assessments of medial temporal lobe atrophy ( vaMTA ) is a rapid method for clinical use.
Visual biofeedback ( VBF ) is an intervention tool that can be used in balance rehabilitation.
Visual cues were either degraded or unmodified.
Visual decline in normal ageing can affect step-climbing ability , altering gait and reducing toe clearance.
Visual defects and GH deficiency were more common in patients with NFPAH compared with patients with PRS and PRDA , without difference of tumor size.
Visual examples of aging over time are particularly effective for teens and young adults.
Visual feedback of the force trajectory and target was provided 1s after each trial.
Visual feedback was provided after each trial.
Visual function , as measured using standard charts , was taken into account in statistical analyses.
Visual grading was done by inspecting the shape of diagram and classified into two states : regular and irregular.
Visual hallucinations are common and often distressing consequences of vision loss , particularly in age-related macular degeneration.
Visual impairment has a broad impact on health , functioning and well-being.
Visual impairment was defined as distance visual acuity < 20 / 40 in the worse-seeing eye.
Visual impairment was defined by self-report.
Visual impairment was found in @percent@ subjects in the worse-seeing eye.
Visual inspection and the statistical best fit of the spline regression models were used together to estimate the best estimate of the thresholds.
Visual inspection of mirrors and the blind spot and the control of the vehicle were documented in a simulator environment.
Visual inspection suggested that changes in the expression of the genes are involved in delaying hair growth in the VC ( - ) group.
Visualization and quantification of the NRC provide some parts of clinical and diagnostic information about pathologic condition of SNc.
Visualization of individual cells expressing zebrafish progerin ( zProgerin / zlamin A-Δ37 ) fused to green fluorescent protein further revealed misshapen nuclear membrane.
Visually impaired patients report increased anxiety related to medication management and must rely on others to obtain necessary drug information.
Visually impaired women from group E showed a lower level of postural stability measured with EO compared to the healthy women.
Visual perceptual learning ( VPL ) with younger subjects is associated with changes in functional activation of the early visual cortex.
Visual phasic measures alone performed worse than all the other measures.
Visual rating scales are a convenient way of assessing atrophy in a clinical setting.
Visual search abilities were relatively consistent across groups.
Visual sensitivity is very poor near birth and improves over different times courses for different visual functions.
Visual short term memory ( STM ) declines as people get older , but the nature of this deterioration is not well understood.
Visual short-term memory ( VSTM ) is a vital cognitive ability , connecting visual input with conscious awareness.
Visual symptoms are the most common presentation , followed respectively by sensory , aphasic , and motor symptoms.
Visual tracking of the surrounding environment is an important daily task , often executed simultaneously with the regulation of upright balance.
Visual working memory ( VWM ) capacity is reduced in older adults.
Visuomotor tracking performance , however , was significantly reduced in the OG as compared to the YG when tested in both standing and walking.
Visuospatial dysfunction and attention / executive impairment predominated.
Visuospatial skills and working memory were worse than expected compared to the typical population.
Vitality level was estimated from the Medical Outcomes Study Short Form @number@ ( SF-36 ) vitality scale.
Vital sign change with age may be subtle because of reduced physiological ranges.
Vital status and physical and cognitive decline have been followed using data derived from long-term care insurance certification.
Vital status and time in study were used to conduct survival analyses.
Vital status , cause of death , and recurrence status were assessed during a median follow-up time of @number@ years.
Vital status follow-up was conducted through @number@
Vital status of study participants was determined through @date@ .
Vital status of the subjects was ascertained and hazard ratios ( HRs ) for mortality according to 25 ( OH ) D₃ quartiles were calculated.
Vital status , recurrence and cause of death were documented for a median follow-up time of @number@ years.
Vital status was ascertained in @number@ men and women aged greater than or equal to @number@ years from the InCHIANTI study.
Vital status was determined from the medical records or public records office.
Vital thermoregulation function of eccrine sweat glands is also altered with age.
Vitamin A and its metabolites have been shown to improve chronologically aged and photoaged skin by promoting deposition of new collagen and preventing its degradation.
Vitamin A intake was excessive due to consumption of fortified sugar.
Vitamin B12 and calcium supplements may alleviate metformin-induced vitamin B12 deficiency and were associated with better cognitive outcomes.
Vitamin B12 deficiency is common among the elderly.
Vitamin B12 deficit is one of the most common vitamin deficiencies.
Vitamin B12 replacement is safe and without side-effects , but prompt treatment is required to reverse the damage before it becomes extensive or irreversible.
Vitamin B-12 supplementation significantly increased serum vitamin B-12 levels ( p < 0.0001 ) and lowered plasma homocysteine ( p < 0.05 ) .
Vitamin B-6 intake was assessed using @number@ 24-h diet recalls and supplement use data.
Vitamin C and E ( alpha-tocopherol ) assays were done on baseline supernatant plasma ( PCA ) and serum samples , respectively.
Vitamin C exhibited a similar pattern to serum carotenoids with an inverse linear association with MetS ( binary ) , HOMA-IR , and hyperuricemia.
Vitamin C intake should be advocated for the primary prevention of cataract.
Vitamin C intake was assessed with a @number@ d estimated dietary record.
Vitamin D3 and its derivates influence directly or indirectly almost all metabolic processes such as proliferation , differentiation , apoptosis , inflammatory processes and mutagenesis.
Vitamin D3 level averaged @number@ ± @number@ ng / mL.
Vitamin D3 significantly promoted RANKL expression in ABCs and OPG in DPCs.
Vitamin D3 supplementation significantly increased serum leptin and OPG levels.
Vitamin D also modulates muscle and bone-derived hormones , potentially facilitating cross-talk between these tissues.
Vitamin D also regulates mineral homeostasis and upregulates klotho expression.
Vitamin D and K are strongly associated with bone metabolism.
Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency.
Vitamin D deficiency ( < 50 nmol / L ) was found in about a quarter of patients.
Vitamin D deficiency could also affect elderly patients ' immunity.
Vitamin D deficiency has been considered as a 25 ( OH ) D of less than 20ng / ml.
Vitamin D deficiency is a common finding in institutionalized older persons.
Vitamin D deficiency is associated with sarcopenia , which is characterized by the decrease in muscle mass and the muscle weakness.
Vitamin D deficiency is defined as a 25OHD level < 20 ng / mL.
Vitamin D deficiency is highly prevalent at all ages , but may not be an independent risk factor for avascular necrosis ( AVN ) .
Vitamin D deficiency is the most under-diagnosed medical condition in postmenopausal women.
Vitamin D deficiency or insufficiency is overwhelmingly associated with viral hepatitis , cirrhosis , and fatty liver diseases.
Vitamin D deficiency seems to be implicated in the onset and progression of some autoimmune disorders.
Vitamin D deficiency should be corrected before the administration of Zol.
Vitamin D-deficient elderly persons are at higher risk of falls and fractures.
Vitamin deficiency disorders display a wide variety of neurologic signs and symptoms , the pathogenesis of which is not clearly understood.
Vitamin D , formed in skin in bright sunshine , is scarce in foodstuffs.
Vitamin D has a crucial role for bone metabolism.
Vitamin D , identified ≈100 years ago , promotes calcium absorption and utilization , preventing and curing rickets & osteomalacia.
Vitamin D insufficiency is common , correctable , and influenced by genetic factors , and it has been associated with risk of several diseases.
Vitamin D insufficiency is defined as a 25OHD concentration of 20-29 ng / mL.
Vitamin D intake was not associated with cognitive performance , glucose metabolism , or depression.
Vitamin D in the food supply is limited and most often inadequate to prevent deficiencies.
Vitamin D is a hormone whose actions take place through a specific receptor , the vitamin D receptor ( VDR ) , which is ubiquitous.
Vitamin D is a potent secosteroid hormone with diverse biological functions that include protection against neuronal damage.
Vitamin D , is a secosteroid which , in its active form @number@ , 25- ( OH ) 2-Vitamin D3 , has hormone activities.
Vitamin D is involved in mineral and bone homeostasis , immune responses , anti-inflammation , anti-infection , and cancer prevention.
Vitamin D levels along with other biomarkers were obtained from a sub-sample of Mexican adults older than @number@ years.
Vitamin D levels are strongly associated with exercise performance in athletes and physically active individuals.
Vitamin D levels in @number@ well-characterized schizophrenia cases were examined with respect to symptoms , cognition , and functioning.
Vitamin D levels were lower when follow-up was > @number@ years , albeit this difference was not statistically significant ( p = .074 ) .
Vitamin D modulates fracture risk in two ways : by decreasing falls and increasing bone density.
Vitamin D plays an important role in bone metabolism and maintaining bone health.
Vitamin D plays crucial roles in neuroprotection and neurodevelopment , and low levels are commonly associated with schizophrenia.
Vitamin D serum level below 80nmol / L was accepted as insufficient.
Vitamin D status was not associated with SOS , and these associations were not modified by the effect modifiers tested.
Vitamin D supplementation has been shown to reduce circulating concentrations of inflammatory markers in such conditions.
Vitamin D supplementation showed no significant benefit on cognition compared with control ( SMD = @number@ CI = @number@ to @number@ ) .
Vitamin E is an important antioxidant that primarily protects cells from damage associated with oxidative stress caused by free radicals.
Vitamin K antagonists ( VKAs ) are the most widely used anticoagulants for stroke prevention in patients with atrial fibrillation ( AF ) .
Vitamin K has been purported to play an important role in bone health.
Vitamin K intake was estimated using the USDA database.
Vitamin K is one of several nutrients that have been linked with bone health.
Vitamins and minerals intake was lower than recommended for both groups ; vitamin E intake was associated with depression.
Vitamins and minerals may be sufficient in the diets of endurance athletes , who have a high energy intake.
VitD insufficiency was not related to the rate of cognitive decline on any test or the risk of developing impaired performance during follow-up.
Vitrification is an attractive alternative cryopreservation approach.
Vivax malaria reemerged in Korea in @number@ and the outbreak has been continued with fluctuating numbers of annual indigenous cases.
VI was defined by presenting distance visual acuity in the better-seeing eye.
V-LH was detected by genotyping of the underlying DNA polymorphisms using PCR-RFLP combined with resequencing of a random subset of subjects.
VLW tau overexpression in SH-SY5Y cells also increased AChE activity levels.
VM-and VA-models were tested against each other to see which model predicts intensity of PA better.
Vmca increased significantly with increase in CO ( @number@ ) ( P < @number@ ) for both boys and girls.
VM-model was found to be a better predictor of PA-intensity than VA-model ( p < @number@ ) .
VMS , serum estradiol , and at-home PSGs ( two pretreatment , two posttreatment ) were measured before and after @number@ weeks on GnRHa.
VMT itself may be associated with epiretinal membrane formation and the development of idiopathic macular holes ( IMH ) .
Vo2max increased in a dose-dependent manner ( P < @number@ ) .
( ( V ) O2max was evaluated through the Bruce protocol with direct measurement of oxygen consumption.
VO ( 2max ) was lower in J than in non-J haplogroup individuals ( P = 0.04 ) .
( ( V ) O2max was significantly inversely related with DNA strand breaks , but this relation disappeared when adjusted for age.
VO ( 2p ) and [ HHb ] responses were modeled as a mono-exponential.
VO ( 2p ) and ∆ [ HHb ] were modeled with a mono-exponential.
VO ( 2p ) was measured breath-by-breath.
VO ( 2p ) was measured breath-by-breath using a mass spectrometer.
Vocabulary-based health literacy skills appear more stable with age.
Vocabulary knowledge , cognitive activities , and education significantly modified the association of CRP and postoperative delirium ( P < @number@ ) .
Vocal imitation is essential for acquiring speech , and it is an important element of social communication.
Vocal training had a positive impact on voice intensity parameters in girls.
VOCs exhaled by centenarians have not been studied in the general population and across-age-groups.
VOI-based cortex-to-cerebellum ratios ( SUVR ) were compared for uncorrected and PVE-corrected results.
Voice disorders ( presbyphonia ) are common in the elderly and have a significant impact on communication and quality of life.
Voice handicap was measured by self-report using a validated voice handicap index questionnaire at baseline and @number@ weeks after intervention.
Voiding cystourethrography ( VCUG ) and renal ultrasound were performed on @number@ infants at @number@ weeks of age.
Voiding difficulties are more common in the elderly.
Volatile organic compounds have been associated with atopic dermatitis.
Volatile organic compounds ( VOC ) are organic chemicals that have high vapor pressure at regular conditions.
Volcano plots showed great overall similarity of retinol and bakuchiol effects on the gene expression profile.
Voltage-dependent gating of the channel was regulated by redox conditions and pH and was affected also in mutants mimicking a phosphorylated state.
Voltage-gated calcium channels conduct Ca ( 2 + ) ions in response to membrane depolarization.
Voltage-gated calcium currents and potassium currents were shown to undergo developmental changes in postnatal human and animal cardiomocytes.
Volume and cortical thickness variations among groups were compared.
Volume changes in the cerebellum and brainstem were contrasted with those in the ventricles and whole brain.
Volume changes were measured across the entire cortex and in @number@ regions of interest.
Volume density of the LH cells did not significantly change , whereas their area significantly increased with age.
Volume enhancement with the use of fat and fillers and muscle manipulation with the use of neuromodulators are discussed.
Volume loss and disruption of white matter integrity may represent early MRI markers for long-term cognitive impairment.
Volume loss is considered to be one of the major contributors to facial aging.
Volume of each brain region was normalized by the whole brain volume in order to minimize age and body size effects.
Volume of the subiculum was unrelated to age.
Volume restoration has become a cornerstone in facial rejuvenation.
Volumes of both the hippocampus and parahippocampal gyrus were significantly different between the groups in the following order : healthy > aMCI > AD.
Volumes of lateral frontal grey matter were found to be significantly lower for OA than MA.
Volumes of these gray and white matter regions were also related to general intelligence.
Volumes of the striatum , including the accumbens , putamen , and caudate nucleus were automatically estimated from T1 MR images.
Volumes of WML and cognitively relevant brain regions were significantly associated.
Volumes significantly correlated with atrophy severity at Scheltens ' scale ( Spearman's ρ = < -0.468 , P = < .0005 ) .
Volumetric analysis against an alternative kNN segmentation revealed high inter-method reliability ( ICC = .97 ) .
Volumetric analysis showed high inter-rater reliability both globally ( ICC = .99 ) and regionally ( ICC = .98 ) .
Volumetric analysis was performed using regions of interest on serially imaged segments of affected nerves.
Volumetric changes attributable to lesion growth and atrophy were quantified with automated procedures.
Volumetric exposure of aged skin to potentially injurious shear stresses was six times greater than in the young skin for these conditions.
Volumetric measurements of PCA and OFC were performed using consecutive 1-mm thick coronal slices of high-resolution 3-D MRIs.
Volumetric measures of WML and atrophy were obtained with @number@ T MRI ; infarcts were rated visually.
Volumetric measures were obtained using a validated segmentation method.
Volumetric measures were significantly greater ( P < 0.001 ) in men than in women , even after adjustment for body surface area.
Volumetric methods for calculating hippocampal volume are time-consuming and commonly used in research.
Volumetric , microstructural , and focal markers of brain tissue were assessed on MRI.
Volumetric quantitative data and cortical thickness were obtained by automatic segmentation using the Freesurfer software.
Volumetric segmentation of cortical and subcortical structures and voxel-based morphometry ( VBM ) were performed.
Voluntary activation was similar between the old and young ( ~98% ) and was unaltered with fatigue.
Voluntary overweight and obese subjects undergoing a CT-scan for diagnostic purposes were included in the study.
Voluntary retirement also increased the risk of cardiovascular disease or stroke among males ( adjusted HR = @number@ @percent@ CI = @number@.533-5.409 ) .
Voluntary running also enhances neuroplasticity in adult and aging rodents , but the molecular pathways underlying these effects are still being elucidated.
Volunteering status was the factor of interest and study factors included a broad range of demographic , health and social factors.
Volunteering was associated with increased quality of life and social support.
Volunteering was directly associated with feelings of usefulness and indirectly associated with depressive symptoms through total physical activity.
Volunteer-run , community-based BP monitoring in senior centers may provide an effective , replicable model for reducing BP in older adults.
Volunteers ( mean age = @number@ N = @number@ ) were assigned to a strength training only or strength training / behavior change 12-week intervention.
Volunteers were classified according to SO definition.
Volunteers were photographed , and skin biopsies were obtained at baseline as well as @number@ and @number@ months after the start of treatments.
Volunteers were submitted to a psychiatric interview and clinical evaluation.
Volunteer work was associated with higher positive affect in both age groups.
Voriconazole combines satisfactory systemic antifungal effect , high oral bioavailability and good bone penetration.
Voxel-based analysis is widely used for quantitative analysis of brain MRI.
Voxel-based analysis was conducted to identify clusters showing tissue concentration differences with t-tests.
Voxel-based analysis with TBSS was used to compare FA among the three groups.
Voxel-based group comparison showed reduced FDG-PET metabolism within the temporo-parietal and prefrontal cortex in HC converters.
Voxel-based group comparison statistics of fractional anisotropy , mean diffusivity and hippocampal structural connectivity were estimated using Tract-Based Spatial Statistics.
Voxel-based group differences were obtained using RMINC.
Voxel-based morphometry analyses were performed separately in the @number@ sample sets.
Voxel-based morphometry and region-of-interest ( ROI ) analysis were used to assess patterns of grey matter loss.
Voxel-based morphometry has been used to investigate the associations between regional gray and white matter volume and cognitive function.
Voxel-based morphometry of structural magnetic resonance images determined the relationship between brain volume and CSF NfL.
Voxel-based morphometry revealed learning-dependent gray matter changes in the left hippocampus in healthy controls.
Voxel based morphometry revealed that higher t-tau was associated with lower GM density in the precunei.
Voxel-based morphometry was used to investigate the correlation between the FFM personality traits and subtle brain structure.
Voxel-based statistical analyses were performed to study the change in DMN activity from T0 to T6 in the two groups.
Voxel-based univariate tests confirmed the plausibility of our findings detecting a distributed network of atrophy in AD patients.
Voxel-by-voxel T2-relaxation values were calculated , and whole-brain T2-relaxation maps constructed and normalized to a common space template.
Voxel-wise ICC and coefficient-of-variation maps showed relatively lower reliability in watershed areas and white matter especially in deeper white matter.
VPP and IPP lactotripeptides assumed as functional foods may significantly reduce SBP particularly in Asian subjects.
VPS35 interacts with VPS26A in the retromer complex that links mitochondrial and lysosomal pathways , which have both been shown to be dysfunctional in PD.
VPS35 mutations have been identified as a cause of autosomal dominantly inherited Parkinson's disease ( PD ) .
VR positive ( VRPos ) and VR negative ( VRNeg ) groups were created based on the presence of one or more VR factors.
VSMCs become increasingly dysregulated , apoptotic , and senescent as we age.
VSM's concurrent validity is supported by the large number of correlations between the VSM and established tests.
VSQ was tested for reliability and validity.
VSTM performance declines with mild cognitive impairment ( MCI ) and medial temporal lobe ( MTL ) amnesia.
VTE causes a major burden of disease across low , middle , and high income countries.
VTE was more prevalent in women than men throughout the study.
VTOC connectivity with posterior parietal , anterior temporal , and dorsolateral prefrontal cortices emerged as the most extensive network predicting individual gains in numerical abilities.
Vulnerability and ageing have generally been associated with frailty , which gives a limited view of both vulnerability and ageing.
Vulnerability to stress ( VS ) is one neuroticism trait that has been linked to worse mood and cognitive outcomes in older adults.
Vulnerability to these challenges can be influenced by genetics.
Vulnerable subgroups tend to be exposed to more deprived places of residence , which may further increase health risks and healthcare needs.
Vulval , vaginal and cervical cancers are not considered hormone-dependent and therefore estrogen therapy can be given.
VWA domains are the predominant independent folding units within matrilins and mediate protein-protein interactions.
W42Q aggregation required formation of a non-native intramolecular disulfide bond but not intermolecular cross-linking.
Waist circumference and arterial blood pressure were also measured at baseline and after the training period.
Waist circumference greater than @number@ cm was also associated with higher risk of earlier death , incident disease , and mobility disability.
Waist circumference was not significantly associated with dementia.
Waist circumstance was associated with decreased LTL ( p < @number@ ) in both males and females.
Waist-to-height ratio has the ability to reflect the compound risk of different cardiometabolic abnormalities and the greatest potential to be widely applied in clinical practice.
Wait lists are primarily driven by the needs of aging populations ( demand-side factors ) .
Walkers of both genders performed better in the following tests : chair stand , one leg stance , maximal walking speed and six min walking.
Walker's point was origin.
Walking ability training in frail elderly inpatients is useful.
Walking ability was assessed by functional ambulation categories and Functional Classification of Sagunto Hospital Ambulation.
Walking activity was measured during one week with a pedometer.
Walking and running have been found to increase hip bone mass in postmenopausal women.
Walking at moderate intensity caused a significant weight decrease in the exercise group , but did not have any significant effect on VO2max.
Walking duration was gradually increased during @number@ weeks , and stayed constant until the end of training period.
Walking football is enjoyable and moderately demanding and may be a sustainable form of exercise for older adults.
Walking has a number of potential benefits for older people in rehabilitation but it is not known whether increased walking improves outcomes in this population.
Walking interventions for older adults should address self-efficacy in overcoming individual walking barriers.
Walking is a complex motor task generally performed automatically by healthy adults.
Walking is a suitable activity for older adults and has physical and mental health benefits.
Walking performance , maximum isometric knee extension / flexion , toe-grasping and handgrip strength were measured.
Walking performance , specifically indoors , declined ( 83%-71% ; P = .010 ) .
Walking speed and Short Physical Performance Battery were examined at baseline and at the 3-year follow-up ( zero-time ) .
Walking speed and step length were measured.
Walking speed did not influence these differences , as they remained present when groups walked at comparable speeds.
Walking speed is a key vital sign in older people.
Walking speed is modulated using propulsive forces ( F Sheehan's syndrome occurs as a result of ischemic pituitary necrosis due to severe postpartum haemorrhage.
Walking speed ( @percent@ , p = @number@ ) and chair stand test performance ( @number@ % , p < @number@ ) were also improved.
Walking speed was measured during a 20-s walking task.
Walking speed was measured over @number@ meters.
Walking the tightrope expressed tensions in meeting professional responsibilities.
Walking was one of the most popular PA modes.
Walking while talking significantly reduced gait speed in both groups ; however , only older adults experienced significant cognitive-motor interference during the Stroop task.
Waning of cellular and humoral immunity to maintenance levels occurred within @number@ months after antigen encounter.
Warfarin confers stroke prevention in patients with CHA2 DS2 -VASc ≥1 and non-self-limiting AF.
Warfarin patients were on average older and received more CV co-medication than NOAC patients in AF and DVT PE.
Warmed blankets are not routinely offered to patients in the psychiatric setting.
Warm temperature during the investigation-as well as adrenergic antagonists-inhibit tissue activity.
Warnings about memory errors can reduce their incidence , although past work has largely focused on associative memory errors.
Warning salience and cognitive responses decreased in Germany and the Netherlands , forgoing did not change in these countries and avoidance increased in Germany.
Warnings did not reduce forgetting in either age group in Experiment @number@
Warts exhibited mild fibrosis significantly more frequently than peritumor skin ( @percent@ vs. @percent@ ; P = @number@ ) .
Was established that compared lines had morphology like fibroblasts , were differentiated in adipocytes , were expressed mesenchymal markers and didn't expressed haematopoietic markers.
Was his condition caused by severe calorie restriction ( CR ) ?
was on hormone replacement therapy.
Was the failure of state-controlled \ "adequate \ " healthcare totally unpredictable ?
Wasting and weight loss occur in HIV infection even in the modern era of effective antiretroviral therapy.
Wasting , stunting , and underweight were defined as z-scores less than @number@
Watchful waiting , pharmacological therapy , and surgery are also helpful , depending on the severity of the disease.
Water-aging for @number@ days had no adverse influence on enamel shear bond strength ( p > 0.1 ) .
Water and pH are now shown to be of prime importance in the regulation of the epidermal enzymes linked to corneocytes desquamation and lipid synthesis.
Water concentration profiles only decrease very close to the skin surface.
Watercress ( Cruciferae ) , an integral part of Mediterranean diets , is a nutritive food which is used in the treatment of several diseases.
Water immersion-induced skin wrinkling ( WISW ) is dependent on intact peripheral sympathetic function.
Water is an essential nutrient for human body and a major key to survival has been to prevent dehydration.
Water is an integral part of collagen's triple helical and higher order structure.
Water-loss dehydration is associated with higher mortality , morbidity and disability in older people , but evidence is still needed that this relationship is causal.
Water mean diffusivity ( MD ) and FA can discriminate the healthy group from osteopenic and osteoporotic group.
Water-soluble , water-insoluble , and protein fractions were extracted from samples.
Water sorption , solubility , elastic modulus , and residual stresses were measured in @number@ commercial composites / cements aged in water and dry conditions.
Water uptake results indicated that biomimetic proteoglycans had a ∼50% increased water uptake compared to native aggrecan and chondroitin sulfate alone.
Water was the most often choice for all patients.
WAT remodeling therefore coincides with obesity and secondary metabolic diseases.
WAVE1 downregulation was observed in mouse models of AD.
WAVE1 interacts and colocalizes with APP in the Golgi apparatus.
Wavelengths utilized for lipolysis liquefy fat and induce collagen remodeling , which tightens skin.
Wave @number@ asked respondents about the frequency of five everyday discriminatory situations.
Wave @number@ BMI did not predict wave @number@ PedsQL.
Wave @number@ BMI strongly predicted wave @number@ BMI and wave @number@ PedsQL strongly predicted wave @number@ PedsQL.
Wave speed is one of the key factors describing wave propagation in arteries [ @number@ ] .
Ways of preventing accelerated aging were outlined.
Ways to maintain and improve positive attitudes about personal aging are discussed in a cultural context.
Ways to protect and improve cognitive health are suggested to encourage positive neuroplasticity and discourage negative neuroplasticity.
WBVG and MTG showed significant increases in isokinetic strength for knee extensors at 60° / s and at 270° / s.
WBV improved other balance and mobility outcomes with inconsistent results.
WBV-plus-exercise was only included if the control group performed the same exercises as the WBV group , but without vibration.
WBVT consisted of four leg exercises three times weekly.
WBVT + L-citrulline decreased cfPWV ( @number@ ± @number@ m / s , P < @number@ ) compared to both groups.
WBV training on top of vitamin D supplementation provided an added benefit with regard to walking , TUG performance , and endurance capacity.
WBVT significantly ( p = @number@ ) improved ROM irrespective of age.
WBVT significantly ( p = @number@ ) improved VCMJ performance when compared to the control groups.
WC change was not significantly associated with mortality.
WC , HS , and HS-based ratios ( HS / Wt and HS / FFM ) were also associated with independence in IADL.
WC increases were not associated with MRI outcomes.
WCOK and W / ht were the indexes most strongly associated with the outcome.
WC remained stable in @number@ ( @percent@ ) , decreased in @number@ ( @percent@ ) and increased in @number@ ( @percent@ ) participants.
We abstracted study characteristics , cardiovascular benefits , and harms.
We accordingly hypothesize that ASTA has therapeutic properties protecting U937 cells from LPS-induced inflammatory and oxidative stress.
We accurately predicted and accounted for these results using generalized invariance structure theory ( GIST ; Vigo , @number@
We acknowledge that not all experts in this field may completely agree with this statement.
We ( a ) conducted a review of the literature , and ( b ) convened an expert panel to provide feedback.
We acquired @number@ minutes of resting-state fMRI data in @number@ cognitively healthy older adults.
We added @number@ tumors diagnosed at our institution between @number@ and @number@ as controls.
We additionally censored for incident stroke.
We additionally compared the integrity of feedforward processing by exploiting the well established phenomenon of suppression of visual cortical responses attributable to interstimulus competition.
We additionally examined the factors that affect suicide with chi-squared tests , t-tests , Pearson's correlation test , and path analysis.
We additionally explored whether conscientiousness , as a marker of self-regulatory skills , is associated with interindividual and age-related differences in positive emotions.
We additionally investigated whether a bout of high intensity interval training additionally alters these patterns.
We additionally pursued cancer-type-specific analyses and uncovered IGF2 as a target for enhancer hijacking in colorectal cancer.
We additionally show that cutaneous vascular responsiveness to adrenergic stimuli is not reduced in older adults.
We additionally show that the defect in NK maturation is the consequence of deficient maturational cues provided by bone marrow stromal cells.
We address differences in the two trials that may account for discordant conclusions.
We addressed changes in neuromuscular control and force output during a ballistic force production task influenced by different environmental dynamics.
We addressed heterogeneity using a shared frailty term.
We addressed the mechanism of action of tPA on oligodendrocyte ( OL ) survival and on the extent of white matter lesions in stroke.
We addressed the question of how age-related changes in gray matter mediate the cognitive performance during middle age.
We addressed the question whether patients diagnosed with mild cognitive impairment or dementia and co-symptoms show alterations in serum parameters.
We addressed this issue by studying NAMPT expression and function in human breast cancer in vivo and in vitro.
We addressed this question by comparing recollection-related cortical reinstatement in young and older adults.
We addressed whether CMV seropositivity influences vascular pathology several years after transplant.
We address the following research questions : Which simulation approach is more suitable for this problem ?
We address the methodological challenges involved in enabling culturally meaningful participation in circumstances where the non-verbal is not equivalent to the non-linguistic.
We address these limitations by specifying distinct health transitions over multiple waves of a 15-year study of American adults.
We address the tensions between ' acceptance ' and fatalismo as a cultural belief , and a function of structural barriers.
We address this hypothesis after keeping the patient in stable dosage of dopamine agonist.
We address this imperative by offering a relevant curriculum through a public-health lens , designed especially for university undergraduate students.
We address this paradox in a molecularly characterised sequential adult cohort with classical and mild variant ataxia telangiectasia.
We address those issues using a verbal paired-associate yes-no recognition paradigm on a lifespan sample of @number@ healthy , well-educated adults.
We adjusted all models for age , education , smoking , and cohort and stratified by surgical vs natural menopause.
We adjusted associations with longevity for demographic , lifestyle , reproductive , and health-related characteristics.
We adjusted for age and sex in analyses of each cohort sample and for smoking status and study site in pooled-data analyses.
We adjusted for the effect of disease-related non-response bias by imputation methods.
We administered the NEO Five-Factor Inventory to assess personality factors.
We administered the S-FNAME to @number@ literate , cognitively normal , Spanish individuals older than @number@ years from the Memory Clinic Fundació ACE.
We adopt a phenotypic redefinition of aging conceptualized within a broader context of HIV infection and of aging.
We adopted a 3-D mental rotation task during fMRI scanning as a visuospatial processing task.
We adopted a simple reward task , which allowed separate evaluation of neural responses to reward anticipation and receipt.
We adopted the Cox proportional hazard model to investigate the effects of diagnosed disease and health-related behaviors on ERdHP.
We agree with regulators that better characterization of subpopulations , not only in elderly patients , can improve the benefit risk ratio of medicines.
We aimed at comparatively evaluating the hemodynamic , echocardiographic and biohumoral profile of a sample of pregnant Caucasian women with different form of pregnancy-related hypertension.
We aimed at comparing the association between GFR estimated using three different formulas and 1-year survival in elderly patients discharged from acute care hospitals.
We aimed at evaluating both the efficacy and safety of YGS in patients with CBS.
We aimed at exploring whether the prevalence of co-morbidities of chronic obstructive pulmonary disease ( COPD ) increases with COPD severity.
We aimed at identifying novel MCPH-associated genes and exploring their functional role in pathogenesis.
We aimed at investigating risk of SPCs after endometrial cancer in Germany and Sweden to provide insight into prevention strategies for SPCs.
We aimed at investigating the risk associated with SALL4 reactivation for all-cause mortality and recurrence in cancer using the current literature.
We aimed at replicating and expanding these findings in an independent study including additional SGG antigens and explored the association with precancerous lesions.
We aimed at testing reliable indices in these patient populations.
We aimed at the characterization of the effects of aging on major ECM proteins in the heart of men and women.
We aimed for a comprehensive evaluation of diagnostic performance of gFOBT by age and sex under routine screening conditions.
We aimed this cross-sectional study to assess the prevalence of physical activity and associated factors among rural elderly Thais.
We aimed to analyse horizontal equity in DMP enrolment among patients with coronary heart disease ( CHD ) .
We aimed to analyse in a cross-sectional study the relationship between Klotho and human coronary artery disease ( CAD ) .
We aimed to analyze characteristics and surgical risks of patients who underwent emergency cholecystectomy for acute cholecystitis without discontinuing APT.
We aimed to analyze the ghrelin response to feeding in lean or obese subjects from birth to adolescence.
We aimed to analyze the levels of these adipocytokines and determine any possible correlations with disease severity or vascular inflammation markers in beta-thalassaemia.
We aimed to analyze trends in incidence and survival of chronic lymphocytic leukemia in Norway.
We aimed to assess associations of morning cortisol with depressive symptoms in mid-life taking account of lifetime psychological health.
We aimed to assess feasibility , reach and costs of implementing a new tailored computer-aided health and social risk appraisal system in primary care.
We aimed to assess intra and inter-rater reliability of the traditional definition of a NF and to demonstrate the potential utility of a new definition.
We aimed to assess QoL during ADT using two validated questionnaires and determine contributing factors.
We aimed to assess the association between dietary fiber and physical performance in older adults.
We aimed to assess the association between red blood cell distribution width ( RDW ) and mortality in patients enrolled by a Geriatric Department.
We aimed to assess the association between the CD4 : CD8 ratio and markers of age-associated disease in treated HIV-infected patients with good immunovirological response.
We aimed to assess the associations of F2RL3 methylation with lung cancer incidence and mortality.
We aimed to assess the evidence available regarding air pollution effects on CVD and CVD risk factors in lower income countries in South Asia.
We aimed to assess the performance of the top hits from previous epigenome-wide association studies in prediction of LC incidence.
We aimed to assess the relationship between amyloid deposition , glucose metabolism and ApoE4 genotype in a clinically heterogeneous population of AD patients.
We aimed to assess the validity of BAI in an older population.
We aimed to assess whether TGF-β1 signaling is affected by age.
We aimed to assess whether the approach of using aging images can be used to recruit young , female smokers for a smoking cessation course.
We aimed to calculate the factual excess in direct and indirect costs associated with epilepsy.
We aimed to characterize echocardiographic measures of structure and function among a group of healthy octogenarians.
We aimed to characterize the neural arch ( NA ) shape at T1-L5.
We aimed to characterize this relationship and to relate biomechanical and structural parameters in a subset of OA patients.
We aimed to clarify the natural history of mild SCH.
We aimed to compare COX-2 expression in chronological aging and photoaging.
We aimed to compare the prevalence of pre- and postmenopausal women with SVH and the characteristics of women with and without SVH.
We aimed to correlate severity of cerebral atherosclerosis , arteriolosclerosis , and cerebral amyloid angiopathy with neurofibrillary tangles , neuritic plaques , and cerebral infarcts.
We aimed to define whether a mtDNA-transcribed long-non-coding-RNA ( lncRNA ) , ASncmtRNA-2 , has a role in vascular aging and senescence.
We aimed to describe anatomical variations in axillary vessels found in our institutional experience.
We aimed to describe disinfectants used by U.S. nurses , and to investigate qualitative and quantitative differences according to workplace characteristics and region.
We aimed to describe health literacy decline during aging and to investigate the roles of cognitive function and decline in determining health literacy decline.
We aimed to describe socio-demographic and clinical characteristics of Brazilian older people with a new episode of LBP presenting to primary care.
We aimed to determine if health literacy is a risk factor for decline in physical function among older adults.
We aimed to determine normal reference ranges for prostate volume ( PV ) and annual PV change rate in a Korean nationwide screening population.
We aimed to determine the effect of continuous positive airway pressure ( CPAP ) on gait in obstructive sleep apnea ( OSA ) patients.
We aimed to determine the extent to which general practitioners and elderly care physicians actually followed the advice of the Health Council.
We aimed to determine the potential use of pro-SFTPB for distinguishing lung cancer cases from matched controls as a risk marker.
We aimed to determine the prevalence of comorbid dementia among hospitalized older adults and evaluate its effects on their hospital course.
We aimed to determine the relationship between lifelong exercise volumes and coronary atherosclerosis.
We aimed to determine the relationship of age-related cataract , cataract surgery and long-term mortality by pooling the results of published population-based studies.
We aimed to determine whether an analysis of P-wave axis can be used to improve risk prediction of AF.
We aimed to determine whether dispositional optimism is prospectively associated with less feelings of loneliness , independently of potential confounders inherent to the aging process.
We aimed to determine whether implementation of a rapid response team ( RRT ) in a tertiary academic hospital improved outcomes.
We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition.
We aimed to determine whether LMTM was safe and effective in modifying disease progression in patients with mild to moderate Alzheimer's disease.
We aimed to determine whether pRCC represents a unique entity or several diseases.
We aimed to determine whether the benefit of the physical activity program in promoting independent mobility was diminished in the setting of intervening hospitalizations.
We aimed to develop and evaluate a psychosocial intervention program that focuses on communication in dementia care.
We aimed to directly quantify the degree to which older adults misjudge their actual gait ability.
We aimed to disclose general trends in bonding to zirconia by systematically collecting zirconia bond-strength data.
We aimed to elucidate the extent of these discrepancies.
We aimed to establish a reference database for Japanese women.
We aimed to establish correlates of psychological distress in study partners of individuals with and without nonclinical MCI.
We aimed to establish serum 17OHP RI in normal children and adolescents using a current 17OHP radioimmunoassay ( RIA ) .
We aimed to establish the neuropsychological profile of mild-moderate MD in relation to mild-moderate AD.
We aimed to estimate prevalence of RLS and investigate its associated comorbid conditions and risk factors in a large population-based door-to-door survey.
We aimed to estimate sex- and age-specific incidence rates of colorectal adenomas and to assess their potential implications for colorectal cancer screening strategies.
We aimed to estimate the incidence and prevalence of AF in Korea between @number@ and @number@
We aimed to evaluate an association between the APOE E4 genotype and cognitive function , and whether this association may differ by age.
We aimed to evaluate circulating values of this new biomarker in a population free of any acute infectious disorder.
We aimed to evaluate mortality and cause-specific rehospitalization rates in this growing population of older adults with ischemic heart disease.
We aimed to evaluate postural balance and PADL in physically independent older adults with different levels of exercise capacity.
We aimed to evaluate predictors of clock drawing test ( CDT ) performance on n = 125 patients attending an internal medicine outpatient clinic.
We aimed to evaluate radiographic correction using XLIF in adults with degenerative lumbar scoliosis.
We aimed to evaluate safety and efficacy of sorafenib in the elderly population.
We aimed to evaluate structural changes in amyloid-negative and amyloid-positive aMCI patients.
We aimed to evaluate the agreement between a wide range of FS in the English Longitudinal Study of Ageing ( ELSA ) .
We aimed to evaluate the clinical implications of F2RL3 methylation , a novel epigenetic biomarker of smoking exposure disclosed by recent genome-wide methylation studies.
We aimed to evaluate the effects of a seated stepping exercise in DT conditions to improve walking ability in community-dwelling elderly.
We aimed to evaluate the impact of age on the favorable results of routine FFR-guided PCI for multivessel CAD.
We aimed to evaluate the inflammatory responses of cationic nanobubbles and micelles in human neutrophils.
We aimed to evaluate the recognition of elder abuse among Italian nurses and nursing students related to their professional , personal experiences and socio-demographic characteristics.
We aimed to evaluate the relationship between lung function and grip strength in older hospitalized patients without known airways disease.
We aimed to evaluate the relationship of RDW with clinical and laboratory parameters in patients with young and elderly CHF patients.
We aimed to examine the association of sAF with glycemic and renal status @number@ years earlier in older persons.
We aimed to examine the literature on change in muscle strength and muscle mass in older patients during hospitalization.
We aimed to examine the longitudinal relationship between depression and the incidence of mild neurocognitive disorders ( NCD ) in a Chinese population.
We aimed to examine the prevalence and characteristics of CHDMs throughout adult life.
We aimed to examine the relationship between BPT achievement and important patient outcomes and whether the BPT could predict these independently of other validated predictors.
We aimed to examine the relationship between relative ( weight percentage ) and absolute ( mg / L ) concentrations of individual circulating PLFAs.
We aimed to examine the relationship between tea consumption and HRQOL among older Chinese adults.
We aimed to examine trajectories of change and shed light on relationships among subjective beliefs and indicators of memory and functional health.
We aimed to examine trajectories of inflammatory markers and cognitive decline over @number@ years.
We aimed to examine whether changes in hand shape patterns during the reaching phase of grasping movements differ between young adults and the elderly.
We aimed to explore correlations between MS and hyperuricemia in a large Chinese population , emphasizing the impacts from gender and age.
We aimed to explore the association between hs-cTnT levels and cardiac and pulmonary dysfunction in patients with stable chronic obstructive pulmonary disease and at-risk individuals.
We aimed to explore the association of homocysteine with familial longevity by testing whether homocysteine is lower in individuals that are genetically enriched for longevity.
We aimed to explore the expression pattern and functional mechanism of Klotho in diffuse large B cell lymphoma ( DLBCL ) .
We aimed to explore the relationship between older age and treatment outcomes in HIV-positive persons from the Asia Pacific region.
We aimed to explore whether COPD and ageing determine malnutrition in different manners.
We aimed to facilitate visual detection sensitivity in the contralateral visual field with both R-atDCS and L-atDCS relative to Sham.
We aimed to generate cognitive charts for use in clinical practice for longitudinal evaluation of age-associated cognitive decline.
We aimed to identify factors associated with lack of awareness of smell dysfunction.
We aimed to identify further parameters for the noninvasive measurement of skin aging of sun-exposed and sun-protected areas utilizing OCT.
We aimed to identify genetic and pathological markers that have the strongest association with these features of clinical heterogeneity in synucleinopathies.
We aimed to identify genetic contributions to verbal declarative memory in a community setting.
We aimed to identify genetic mutations in @number@ Chinese pedigrees with dominant ataxia but excluded dynamic mutations of SCA genes.
We aimed to identify genetic risk factors for ALS in the Finnish population.
We aimed to identify moderators of the effectiveness of aerobic exercise intervention in maintaining increased aerobic exercise among older individuals.
We aimed to identify novel risk loci for Parkinson's disease.
We aimed to identify the causes and risks of death among TB patients.
We aimed to identify the effects of aging on phaselocking measures of @number@ Hz ASSR.
We aimed to identify the target antigens of anti-CarP antibodies.
We aimed to investigate and compare regional neuromuscular activation patterns along the RF muscle between the young and elderly during the stair walking.
We aimed to investigate inter-physician variation in follow-up procedures after screening colonoscopy in an opportunistic CRC screening program.
We aimed to investigate mutations and to characterize phenotypes in Chinese EOFAD families.
We aimed to investigate predictors for cGM volume in ischemic stroke patients with confluent WMC.
We aimed to investigate prevalence of moderate to severe CKD and its risk factors in the region.
We aimed to investigate the association between air pollution and non-specific perceived stress , often a precursor to development of affective psychiatric disorders.
We aimed to investigate the association of serum fetuin-A and metabolic syndrome ( MetS ) in a community based Chinese population.
We aimed to investigate the association of serum phospholipid PUFAs with cardiometabolic risk through cross-sectional / experimental studies.
We aimed to investigate the effect of a single-session tVNS on associative memory performance in healthy older individuals.
We aimed to investigate the effect of a targeted individualized falls prevention program in a geriatric rehabilitation hospital.
We aimed to investigate the effects of APOE genotype on regional cerebral glucose metabolism in cognitively normal ( CN ) elderly.
We aimed to investigate the effects of CRT on libido and ED.
We aimed to investigate the influence of the p.A152T MAPT variant on the clinical and neuropathological features of these Basque GRN families.
We aimed to investigate the prevalence and long-term outcome of preclinical Alzheimer's disease according to these criteria.
We aimed to investigate the prognostic value of tumor-infiltrating neutrophils in TGCTs.
We aimed to investigate the relationship between serum Klotho levels and early atherosclerotic predictors , including EFT , FMD and CIMT in healthy adults.
We aimed to investigate the temporal and regional evolution of GM volume loss over 5years and its relationship with disability progression in early PPMS.
We aimed to investigate the usefulness of established frailty criteria for community-dwelling Korean elderly.
We aimed to investigate this relationship in humans.
We aimed to investigate whether a phenotype related to healthy metabolic aging could be identified in individuals carrying the longevity-associated FOXO3A rs2802292 G-allele.
We aimed to investigate whether cerebrospinal fluid ( CSF ) concentrations of α-synuclein are of additional diagnostic value.
We aimed to investigate whether hippocampal TDP-43 is associated with increased rates of hippocampal atrophy.
We aimed to investigate whether oxidative DNA damage and occur in WML and in apparently normal white matter in cases with lesions.
We aimed to investigate whether quadriceps strength tests demonstrate similar predictive ability for incident falls as gait speed in older women.
We aimed to investigate whether urinary neopterin levels are associated with cognitive function in people with Down syndrome ( DS ) .
We aimed to model projected change in the distance between the entry point of the electrode into the brain and target during growth to adulthood.
We aimed to obtain normative values for the BASMI in healthy men and women in a UK population.
We aimed to operationalize the ARWMC scale and investigate the effect of this operationalization on the reliability and validity on MRI and CT.
We aimed to project the availability of liver grafts in the United States.
We aimed to provide a detailed assessment of the sensitivity of FIT according to type and subsite of neoplasms in a true screening setting.
We aimed to provide an overview of published studies on blood autoantibody markers for early detection of CRC and to summarize their diagnostic performance.
We aimed to provide a review and synthesis of the evidence regarding the performance of single-item tests for detection of cognitive impairment.
We aimed to provide more detailed results on this association from a population-based patient cohort study.
We aimed to quantify generation shifts in smoking over a period of @number@ years.
We aimed to report the psychometric characteristics of a Spanish version of FNAME ( S-FNAME ) when administered to Spanish-speaking people.
We aimed to reproduce these results , but were not able to detect the tau forms in CSF.
We aimed to reveal the association of clinical / geriatric factors with survival period or postoperative events in such patients who underwent surgery.
We aimed to reveal the relative sensitivity of these tools in a memory clinic setting.
We aimed to review critically the evidence on the effects of this structured intervention programme and to identify gaps to be filled by future research.
We aimed to show whether or not handgrip strength may be used instead of body mass index ( BMI ) in MNA-SF test.
We aimed to study frequency of spirometric obstruction , its over / under diagnosis and tobacco exposure in a group of male nursing-home residents.
We aimed to study temporal trends in the incidence and prognosis for AS in Sweden.
We aimed to study the effects of aging on gait and prefrontal activation in complex walking tasks with internal and external task demands.
We aimed to study the impact of vitamin B-12 supplementation on these markers , in the vegetarians.
We aimed to study the incidence , clinical characteristics , and prognostic impact of transient and persistent AKI in such patients.
We aimed to study the influence of multifactorial causes of change in BMI , over @number@ years.
We aimed to study the long-term cardiovascular outcomes of antiplatelet-related ICH survivors , and the risk of recurrent ICH with antiplatelet resumption.
We aimed to study the prognostic utility of age and pre-arrest comorbidities.
We aimed to study the relationship between MAP and aortic stiffness , brachial stiffness , and arterial stiffness gradient.
We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease ( AD ) biomarkers.
We aimed to suggest WC and VFA criteria and to compare the predictability of WC and VFA to identify people at risk for MetS.
We aimed to systematically review epidemiological evidence on the prognostic role of comorbidity and frailty in CRC patients.
We aimed to test the hypothesis that folic acid supplementation alters DNA methylation profiles in AD models.
We aimed to test the performance criteria of the modified Richmond Agitation Sedation Scale ( mRASS ) in identifying delirium in older ED patients.
We aimed to test the prognostic role of the B-K fusion in progression of incompletely resected PLGA.
We aimed to validate this association in a population-based study conducted in rural Ecuador.
We aimed to verify the linkage of concepts with the use of semantic associative relations.
We aimed to verify whether multimorbidity influenced cognitive and daily functioning during nine years after dementia diagnosis compared with the influence in persons without dementia.
We aimed to verify whether the postural VC difference increases with age and reflects diaphragm weakness in DMD.
We aim to assess the role of executive functioning , global cognitive status , visuospatial abilities , and semantic knowledge on Shulman's CDT performance.
We aim to characterize the variation of health status in a 60 + old population using five indicators of health separately and in combination.
We aim to conduct a systematic review to assess the effectiveness of health promotion interventions on social isolation or loneliness in older people.
We aim to evaluate the effectiveness of multivitamin / mineral supplements for decreasing the risk of age-related cataracts by conducting a systematic review and meta-analysis.
We aim to further investigate this by using meta-analysis of seventeen clinical studies of cognitive intervention for MCI.
We aim to identify genetic loci that modify the association between TCA use and RR and QT intervals.
We aim to investigate lay perceptions of successful aging among the elderly individuals in Singapore and further examine variations of these perceptions.
We aim to investigate the risk of HBV reactivation during DAA therapy.
We aim to provide a methodological framework for their systematic validation , by reference to that developed for oncology biomarkers.
Weakening of the chaperone defense with age probably contributes to the frailty in senescence.
Weaker associations were observed for stiffness index.
Weaker relationships between worry / anxiety and insomnia occurred for those drinking.
Weak grip was predictive for changes in executive function ( β - @number@ p = 0.008 ) .
Weak trust in family and friends or neighbours and decreased functional ability seem to indicate a subjective feeling of ' insecurity'.
We allowed elastin stiffness and collagen recruitment parameters to vary and adjusted residual stress parameters according to published age-related changes.
We allow for trait heterogeneity effects.
We already described an alternative technique of temporary percutaneous ileostomy ( TPI ) , which can be removed without surgery.
We also added health literacy variables to explore their influence on pregnant women's intention.
We also address cognitive aging and attempt to specify which altered cognitive functions negatively impact balance and walking.
We also addressed the influence of cognitive functioning and social support on the relationship between pain and depressive symptoms among community-dwelling older individuals.
We also address low-grade chronic inflammation , prevalent in aging adults and a cause of many disorders including those associated with body composition.
We also address potentially modifiable elements of care and provide several recommendations to improve the management of PD in these facilities.
We also address several pitfalls that can potentially hinder a fast and efficient continuation of this vital progress.
We also address some considerations and limitations with data analysis and interpretation.
We also address some features of birds ' aging that make this group unique and perspective model organisms in longevity studies.
We also aim at integrating the different approaches so to devise a holistic intervention in which synergies among the methodologies to be applied occur.
We also aimed at finding links between the expected changes in the data obtained in static posturography and in clinical balance tests through our program.
We also aimed to assess whether dual task conditions have an added value over single tasks for fall prediction.
We also aimed to develop an in vitro term placental explant culture model to test the aging pathways.
We also aimed to identify which endocrine pathway underlies the responses.
We also aimed to investigate whether use of psychotropics is related to pain in persons with and without dementia.
We also aimed to provide an Asian consensus recommendation for the individual wrinkle pattern.
We also analysed mtDNA copy number , for which changes as a result of oxidative stress have been described in different experimental settings.
We also analyzed APOE4-related atrophy.
We also analyzed clinical variables such as SCC location , location in exposed areas of the skin , age , sex , and immunosuppression.
We also analyzed GSTP1-1's association with TRAF2 at the cellular level.
We also analyzed serum-tau levels in healthy volunteers as a control group ( n = @number@ ) .
We also analyzed the age and gender effects of LV volume and diffusivity.
We also analyzed the association between BMI and epigenetic age in young and elderly individuals , but these associations were not significant.
We also analyzed the correlated factors influencing the serum sulfatide level , using multiple regression analysis.
We also analyzed the effects of increased predation on various parameters related to density dependence and energy allocation.
We also analyzed the fat-related phenotypes of a candidate gene in knockout mice.
We also analyzed the interactions between environmental factors and these genes in influencing cognitive aging.
We also analyzed the interactions between lifestyle and these genes in influencing cognitive aging.
We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2 , ATXN2 and ATXN3 , and ATXN2 and CACNA1A.
We also analyzed the relationship between changes in vitamin K intake and the evolution of bone quality markers after two years of follow-up.
We also analyzed the responses of @number@ marathon and half-marathon runners to a questionnaire about sports , lifestyle , and health.
We also analyzed the sensitivity of T cells from four classical A-T patients to CD95-mediated apoptosis using TUNEL and caspase-activation assays.
We also analyze how various facial regions such as binocular and mouth regions influence age estimation and recognition capabilities.
We also analyze the clinical spectrum of HGPS by comparing the @number@ patients.
We also argued that episodic recollection should be configural ( tending towards all-or-nothing recall of the WWW elements ) .
We also asked for their contact information if they were interested in being contacted as potential participants in the trial.
We also asked participants to estimate the approximate age by which people develop and lose CP across adulthood.
We also asked whether the immature pattern resembles that of people with cerebellar dysfunction , because we know that this adaptation depends on cerebellar integrity.
We also assessed affective responses as a potential mechanism behind age effects and considered other potential covariates.
We also assessed anticholinergic load using the Anticholinergic Cognitive Burden scale.
We also assessed correlations between WMH volumes and cardiovascular , HIV severity , cognitive scores , and diffusion tensor imaging variables.
We also assessed how these care ideals have shifted in the early twenty-first century.
We also assessed liver function in @number@ age-mismatched recipients.
We also assessed objective and subjective sleep parameters.
We also assessed PREPARE ease-of-use ( 10-point scale , @number@ being the easiest ) .
We also assessed the cognitive decline per unit time ( i.e. , the rate of cognitive decline ) .
We also assessed the relation between dysglycemia and cognitive performance.
We also assessed the relationship between this phenotype and mortality in a nested case-control study of ART-suppressed chronically infected individuals.
We also assessed whether these relations were modified by vascular risk factors , notably blood pressure.
We also assess the cost of care with the help of the proxy good method.
We also assess the extent to which these patterns vary by gender , race , and education.
We also assess whether these patterns differ by sex , race , or Southern birthplace.
We also autopsied her sister who was considered to be neurologically asymptomatic and died of tuberculosis at the age of @number@ years.
We also briefly cover other ageing genes identified by comparing worms and yeast , addressing the likelihood that their mammalian counterparts will affect longevity.
We also calculated mean regional cerebral blood flow ( rCBF ) within regions of interest configured for each arterial territory distribution.
We also calculated occipital alpha mean frequency , alpha peak frequency at maximum amplitude , alpha peak width , and theta regional mean frequencies.
We also calculated sensitivity and specificity using physician diagnosis as the reference standard.
We also carried out biochemical analyses of human brain tissues and studied the effects of the aggregated amylin on endothelial cells ex vivo.
We also catalogue structural variants , including @number@ million insertions and deletions , and @number@ genic copy-number variants.
We also categorized outcomes by trial lengths of ≤ @number@ year ( short term ) and > @number@ year ( long term ) .
We also checked the reference lists of relevant articles to identify any additional studies.
We also claim that the proper order of surviving and self-killing mechanisms is controlled by a positive feedback loop between PERK and IRE-1 branches.
We also collected information on socioeconomic status and health behaviors in subpopulations.
We also collected self-report measures of sleep disturbance.
We also compared cognitive testing and longevity outcomes between HS-Aging cases and a subsample with non-tauopathy FTLD ( n = @number@ ) .
We also compared epigenetic signatures in adipose tissue and blood.
We also compared median age at cancer diagnosis by AIDS status and CD4 count.
We also compared multiple analysis approaches , including univariate and multivariate methods.
We also compared pMRCI between patients with ischemic cardiomyopathy ( ISCM ) versus nonischemic cardiomyopathy ( NISCM ) .
We also compared sex differences between freestyle swimming and marathon running.
We also compared the dense-core plaque burdens in the mice to those measured in a set of pathologically-confirmed AD cases from the Nun Study.
We also compared the differences of PLT and the related angles between active and passive falls.
We also compared the effect of aging on these products to identify changes in size distribution and posttranslational modifications.
We also compared the MCW of children with different types of OI regarding the number of pamidronate cycles and age at the beginning of treatment.
We also compared the proportion of patients with rapid decline of renal function across tertiles of change in serum leptin between baseline and 6-years follow-up.
We also compared the risk of harvest to reproductive status and horn length.
We also compare the molecular process of mitophagy with other types of specific autophagic pathways and discuss its biological importance.
We also conclude that early cleavage of the zygote is not a reliable predictor for pregnancy potential using the GnRH antagonist protocol.
We also conducted antisense A20 and siRNA studies to investigate the regulatory role of zinc in TNF-α and IL-1β via A20.
We also conducted a random effects meta-analysis of the available literature , synthesizing the results of three comparable published articles and our local study.
We also conducted follow-up surveys in @number@ to capture the social capital measured by trust.
We also conducted two clinical studies with a total of @number@ Korean women for @number@ weeks.
We also confirmed negative effects of TV viewing on verbal intelligence quotient ( IQ ) in cross-sectional and longitudinal analyses.
We also confirmed that copper treatments promote APP expression and Aβ secretion.
We also confirmed the imprint of past exposure to depression , as those with remitted MDD had shorter TL than controls.
We also confirm that aged Trpv1 ( - / - ) mice are overweight.
We also consider both shared random effect and latent class ( LC ) approaches in the primary-outcome model to predict a binary outcome of interest.
We also considered longitudinal clinical data.
We also considered preventative therapy in latently infected elders , a strategy limited by resource constraints and the risk of adverse events.
We also considered the effect of adenosine triphosphate-binding cassette G2 protein ( ABCG2 ) genotype and renal function on paracetamol pharmacokinetics in these patients.
We also considered the role of potential confounders including sociodemographic factors , health factors , depressive symptoms , and stress.
We also consider the evidence for a perturbed permeability barrier in nuclei from old cells and the alteration of nuclear transport pathways under stress conditions.
We also consider the feasibility of angiogenic therapy for stroke and its optimal timing.
We also consider whether educational attainment explains any group differences , or if differences across groups vary by level of education.
We also constructed Cox regression models allowing a different vitamin E effect for low and high age ranges.
We also could not definitively demonstrate between-group differences in mean SPPB or SPSM values.
We also created a ' Risk of bias ' and applicability concerns graph to summarize information related to the quality of included studies.
We also critically discuss proposed pathways interlinked with mammalian mtDNA mutations and suggest future research strategies to elucidate the role of mtDNA mutations in aging.
We also demonstrated ADAM10 expression potentiates adult hippocampal neurogenesis , which is reduced by the LOAD mutations.
We also demonstrated a significant decrease in osteoblastogenesis in bone marrow stromal cells derived from Cd47 ( - / - ) mice.
We also demonstrated increased incidences of AB , not only in CIS , but also in the background and control epithelia with excessively shortened telomeres.
We also demonstrated that concomitant with the amelioration in cognitive function , taurine caused significant alterations in the GABAergic and somatostatinergic system.
We also demonstrated that triolein could inhibit cerulenin-induced MMP-1 expression.
We also demonstrate how orientation of breast tissue changes in temporal study.
We also demonstrate that AD has a particular effect on hub-like regions in the brain.
We also demonstrate that food composition is an important environmental parameter influencing stress resistance and reproductive phenotypes of both Lipocalin mutants.
We also demonstrate that hEXO1 is rapidly recruited to DNA DSBs.
We also demonstrate that Htt co-localizes with BAIAP2 in filopodia and that mutant HTT interferes with filopodial dynamics.
We also demonstrate that increased hippocampal volume is associated with greater serum levels of BDNF , a mediator of neurogenesis in the dentate gyrus.
We also demonstrate that , in these studies , cellular composition explains much of the observed variability in DNA methylation.
We also demonstrate that the mitochondrial redox balance is perturbed in catalase-deficient cells and upon generation of excess ROS inside peroxisomes.
We also demonstrate that vessel stabilisation and tumour growth require Akt activation in endothelial cells but not in pericytes.
We also demonstrate the advantage of within-subject designs over between-subject designs.
We also describe current drug therapies in two disease states with a predilection for older adults : Alzheimer's disease ( AD ) and osteoporosis.
We also described and compared the frequency of neuropathological diagnosis to clinical diagnosis of dementia subtype.
We also describe methods for evaluating physiological impact of AV.RSV.MCAT on muscle contractility and running performance in mice.
We also describe sex-related findings from the ENIGMA consortium , and ongoing efforts to better understand sex differences in brain circuitry. © @number@ The Authors.
We also describe state-of-the-art acquisition and analytical techniques to reveal physiological information on the mechanisms underlying measured BOLD signals.
We also describe the major target tissues in which distinct adiponectin multimers exert their functional roles.
We also describe the overlap with the previously reported genomes of @number@ supercentenarians individuals aged ≥110 years.
We also describe the redox-regulated signaling networks controlling the SASP and its important role in driving age-related diseases.
We also describe the structure and regulation of Barx genes and possible gene / disease associations.
We also detail an improved methodology to study bony aging to contribute to additional research in the field.
We also detailed pharmacokinetic characterization of FK-A11 in mice.
We also detail RBPs as targets of current anti-inflammatory modalities and how this may translate into better treatment for vascular inflammatory diseases.
We also detected progressive loss of CB , CaMKIδ , and GAP43 proteins in BF homogenates in aging and AD.
We also determined how the NAP1L1 chaperone modulates these activities.
We also determined if an enhanced risk model with control beliefs improved identification of individuals with low vs. high mortality risk.
We also determined proteasome activity in these cells , using a degron-destabilized green fluorescent protein ( GFP ) -based reporter protein.
We also determined that neuronal exosomes , but not glial exosomes , had abundant glycosphingolipids and could capture Aβ.
We also determined that rs4727380 correlates with AD diagnosis primarily among APOE4 noncarriers.
We also determined that these macrophages are critical for influenza-induced mortality with aging.
We also determined the capacity of T cells to respond against immunodominant Ags from CMV in a smaller group of LLS subjects and controls.
We also determined the functional correlates of variations in GM microstructure by obtaining resting-state fMRI and behavioral data.
We also determined whether leptin predicted mortality in patients with obesity.
We also determined whether PSAV altered the probability of overall and life-threatening CaP at PSA levels < 3 and 3-10 ng / mL.
We also developed a prediction equation model using anthropometric measurements.
We also discuss appropriate tools and experimental models available to study the age-related tactile decline.
We also discuss aspects of care that may not commonly be considered in those under the age of @number@ specifically multimorbidity and polypharmacy.
We also discuss consequences for strategies to rejuvenate the immune repertoire in old age.
We also discuss data linking autophagy to the regulation of the microglial inflammatory phenotype , which is known to contribute to age-related brain dysfunction.
We also discuss evidence that p53 controls energy production by repressing glycolysis and enhancing mitochondrial oxidative metabolism.
We also discuss findings that suggest that aging is a more important factor that can negatively impact the function of the UPS.
We also discuss here the potential utility of the restriction of food-derived AGEs in diabetic vascular complications.
We also discuss how aging processes and physiological changes in our body are reflected in adaptations of activity in the spinal cord motor circuitries.
We also discuss how each pathway contributes to modulate the ageing process.
We also discuss how neurogenesis is finely shaped by learning for the purpose of mnemonic information processing.
We also discuss how such DC-AECs crosstalk will provide insight into the mechanisms underlying the increased susceptibility of the elderly to pulmonary inflammatory diseases.
We also discuss how these mechanisms integrate environmental stimuli such as nutrient stress to regulate stem cell function.
We also discuss new perspectives of gerontology in the light of the discovery made by Enríquez's group.
We also discuss noninvasive diagnostic options to identify and characterize cardiotoxicity.
We also discuss novel approaches for prevention and treatment of defective bone formation and bone loss associated with aging and osteoporosis.
We also discuss potential strategies to block photoageing of skin by inhibiting angiogenesis and / or promoting lymphatic vascular function.
We also discuss recent findings that link the NPC and its immediate surroundings to the process of cellular aging.
We also discuss some of the functional ramifications in the brain from NSC aging.
We also discuss specific strategies for involving caregivers.
We also discuss studies that associate BER deficiency with disease risk and the current state of BER capacity measurement assays.
We also discuss the ability of global matching models to account for findings in other studies that have used variants on mnemonic similarity tasks.
We also discuss the areas that future research needs to point towards.
We also discuss the cost-effectiveness of such interventions.
We also discuss the development of novel therapeutic strategies based on CREB targeting to ameliorate cognitive decline in aging and cognitive disorders.
We also discuss the effects of various carbohydrates and carbohydrate-derived metabolites on aging in model organisms and cultured mammalian cells.
We also discuss the efficacy , safety , and pharmacokinetics of cannabinoid-based drugs in older people with dementia.
We also discuss the new therapeutic strategies based on natural selection which the model proposes.
We also discuss the potential for additional study to increase understanding of the aged kidney and lead to novel therapeutic strategies.
We also discuss the potentially exciting role of FGF21 in improving our health and prolonging our life span.
We also discuss the practical problems of its application , which may ultimately define the feasibility of its adoption into routine clinical practice.
We also discuss therapies targeting nerve growth factor or sclerostin for treating skeletal pain.
We also discuss the rising interest in targeting nucleolin therapeutically.
We also discuss the therapeutic and diagnostic implications of these exciting progresses and consider some key issues in the clinical translation.
We also discuss the therapeutic potential of targeting mitophagy and directions for future investigation.
We also divided the Memory Group by Risk Status - Low , Medium , and High.
We also emphasize that the capacity of AMPK to repress inflammatory responses can have a significant impact on both healthspan and lifespan.
We also estimated a discrete time hazard model that predicted first reported episode of homelessness.
We also estimated anaphase bridge ( AB ) , which is inferred to be related to chromosomal instability.
We also estimated the incidence of progression from CIND to dementia.
We also estimate the cost of developing the pilot project.
We also estimate the proportion that receive or expect to receive U.S. social security benefits.
We also evaluated brain activity at rest and during a hippocampal-dependent pattern separation task.
We also evaluated CD11c expression , as T-bet + CD11c + B cells are expanded in healthy elderly individuals and also in patients with autoimmunity.
We also evaluated effect modification by season ( April-September and March-October for warm and cold season , respectively ) .
We also evaluated relationships with age , reproductive and hormonal history , weight , alcohol intake , and smoking.
We also evaluated the associated impact of the APOE4 genotype.
We also evaluated the association btween monitored ambient temperature ( central ) and the same outcome.
We also evaluated the correlation between nerve diameter and sex and age.
We also evaluated the effect of age on the FFR result of varying degrees of visually estimated coronary stenosis.
We also evaluated the effect of EO and FO on photoaging of skin cells exposed to ultraviolet radiation.
We also evaluated the performance of the Six-Minute Walk Test , the 30-Second Chair Rise Test and the Timed Up and Go Test.
We also evaluated the proposed algorithm in an aging study , successfully reproducing some well-known results in cortical and subcortical structures.
We also evaluated the relationships between gonadal dysfunction and in-hospital mortality.
We also evaluated the sensitivity and specificity of MP visualization by pCLE , using pathological presence / absence of MP as the gold standard.
We also evaluated the tear-fluid amino acid profiles from @number@ affected subjects.
We also evaluated VACS Index changes with frailty status transitions over time.
We also evaluate whether these differences can be attributed to physiology or methodology.
We also examined childhood trauma , a risk factor for both PTSD and short LTL , as a potential contributor to short LTL in PTSD.
We also examined decision outcomes in relation to participants ' preferences.
We also examined demographic , clinical and genetic predictors of the impact of androgen deprivation therapy on hot flash interference.
We also examined effect modification by personal characteristics , confounding by air pollution , and the exposure-response function.
We also examined how the network types were associated with social isolation , relationship quality and loneliness.
We also examined how this relationship was modified by gender and the nature of the job loss.
We also examined its association with the incidence of asthma and COPD in patient cohorts.
We also examined neural influences and trophic factors , particularly insulin-like growth factor-I ( IGF-1 ) .
We also examined potential interactions between life satisfaction and health behaviors.
We also examined relations between life stories and personality traits.
We also examined risk factors for specific causes of death in older adults with OUD.
We also examined specific aspects of the questionnaire correlated with bone mineral density.
We also examined SPP1 expression in patients with amyotrophic lateral sclerosis ( ALS ) , a disease characterized by the degeneration of motor neurons.
We also examined the association of ISEL scores with CG severity , and with clinical and sociodemographic variables.
We also examined the association of the mHAI with mortality across individuals with different levels of clinically recognizable comorbidities.
We also examined the associations between @number@ diabetes risk-associated SNPs , identified from genome-wide association studies , and glioma risk.
We also examined the current trends in surgical treatment for these disorders and discuss future care needs.
We also examined the default mode network ( DMN ) , which influences behavior through reduced activity during tasks.
We also examined the effect of age , gender and visual problems.
We also examined the effect of in vitro carbonylated albumin on mRNA levels of endothelial cell adhesion molecules involved in early atherogenesis.
We also examined the impact of antihypertensive treatment on WML progression.
We also examined the influence of these factors on the relationship between efficiency and quality.
We also examined the outcome of a diagnosis of PTSD ( n = @number@ ) versus no PTSD diagnosis ( n = @number@ ) .
We also examined the performance of self-report measures reflecting psychosocial and well-being constructs , given the prevalence of cognitive impairment in nursing homes.
We also examined the relationship between baseline threshold and the deterioration rate.
We also examined the relationship between network connectivity , migraine frequency , and sensory sensitivity symptoms.
We also examined the transcript for missed cues and the impact of closed questions when administrating questionnaires to older people living in care home facilities.
We also examined this novel polymorphism -573A / G in another Han Chinese sample from Yunnan province , and it was not associated with longevity.
We also examined whether age differences in divergent thinking might underlie the reduced episodic detail generated by older adults.
We also examined whether the age-dependent changes differ among physical performance and body composition parameters.
We also examined whether the age-related decline in REE was explained by concomitant changes in body composition and lifestyle factors.
We also examined whether the responses varied by age , sex and socio-economic position ( SEP ) .
We also examined whether these associations were modified by genotype or phenotype.
We also examined which types of newspapers were most likely to publish health news stories.
We also examine key clinical questions regarding CRT still under research , including predictors of response.
We also examine the effect of pharmaceutical innovation on hospital utilization.
We also examine their appropriate application , limitations , clinical outcomes , and associated complications.
We also examine the role of living arrangements in well-being differentials across regions.
We also examine the role of the intron enhancer , Eμ , in establishing the pre-rearrangement chromatin structure.
We also examine whether these associations differed systematically by age , race / ethnicity , gender , education , and income.
We also expand our approach to settings with multiple mediators and derive the mediated effects , jointly through all mediators.
We also explored any interaction effect between sex and sleep quality / duration on memory.
We also explored feasibility of the DLS modeling approach to predict physical activity EE ( PAEE ) and METs.
We also explored if natalizumab applied before regular monthly SDMT may influence practice effect and cognition.
We also explored potential mediators including neighborhood socioeconomic status , perceived neighborhood cohesion and perceived neighborhood physical disorder.
We also explored the combined effect of birth size and midlife body mass index ( BMI ) on type @number@ diabetes in old age.
We also explored the relationship between depression and excessive daytime sleepiness by age at onset and compared this with the general population.
We also explored the relationship between limb asymmetry and physical functioning.
We also explored the simple effect of each independent variable on role strain.
We also explored whether associations varied by smoking , by family history or clinical features of prostate cancer.
We also explored whether a tumor-related tracheal defect was successfully reconstructed after full-layer tracheal resection.
We also explored whether social support and physical activity mediated the relationships between stress and mental health problems.
We also explore the contribution of brain inflammation to defective insulin signaling and neuronal dysfunction.
We also find BLBP expressed by proliferative ventricular and subventricular progenitors in the fetal and postnatal human brain.
We also find some evidence that height serves as a protective factor against age related deterioration in cognitive functioning.
We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume.
We also find that aging and urbanization can substantially influence emissions in particular world regions.
We also find that better perceived health insurance coverage is associated with a healthier lifestyle which is not compatible with an ex-ante moral hazard interpretation.
We also find that greater numeracy is associated with a lower willingness to pay for choice.
We also find that Shh stimulation of GNPs promotes MDM2 accumulation and enhances phosphorylation at serine @number@ a modification known to increase MDM2-p53 binding.
We also find that the impact of explanatory factors varies across states and offense types.
We also focus on the relationship between platelets and the lipid metabolism highlighting potential consequences to atherosclerosis and dyslipidemia.
We also focus on total , institutional and domiciliary LTC separately.
We also found a gradual , year-by-year slowing of the peak α frequency with increasing age.
We also found a larger CNV on context-dependent than on context-independent trials , reflecting active maintenance of context information and response preparation.
We also found an interaction between the BDNF Val66Met SNP and age with whole brain volume.
We also found a progressive increase in allele burden with age ( R2 = 0.042 ) .
We also found a related increase in CA3 / dentate gyrus activity levels during an fMRI contrast that stresses pattern separation abilities.
We also found a significant APOA2-saturated fat interaction in determining IR in Chinese and Asian Indians ( P = @number@ ) .
We also found a significant correlation between VT and age for both HABs and MABs in most ROIs.
We also found a significant positive correlation between subject age and OSI ( r = @number@ p < @number@ ) .
We also found correlations between arterial health and both cortical and subcortical gray matter volumes.
We also found distinct patterns of regional spectral power changes in each primary progressive aphasia variant , compared to age-matched controls.
We also found evidence that higher plasma zeaxanthin , but not lutein , was associated with better processing speed.
We also found , however , a great inter-individual variability in the cognitive performance responses to caffeine.
We also found intraindividual coregulation of mitochondrial and proteasomal activities in all human fibroblast strains tested , suggesting that both systems are interdependent.
We also found potentially relevant changes in genes related to additional processes , including thermoregulation , sensory perception , dietary adaptations , and immune response.
We also found significant ageing effects in fronto-temporal grey and white matter , independent of the effect of HIV.
We also found significant age-related changes in volume and MKT of CA in striatum and thalamus that are different to those seen in normal aging.
We also found significant wave effects for all @number@ sex hormones.
We also found that activating ERK1 / 2 by hyperthermia did not correlate with increased tau phosphorylation.
We also found that Advanced age is associated with reduced within-network functional connectivity , particularly within the default mode network.
We also found that among @number@ participants with symptomatic autonomic neuropathy , the diagnosis had been considered for only one.
We also found that an increase of the adipose tissue mass in uPAR- / - mice was less than that observed in wild-type mice.
We also found that aTNKS had no effect on telomerase activity.
We also found that before motor neurons began to die in adulthood , axon guidance defect of motor neuron appeared during the development stages.
We also found that CMV-seropositivity is associated with increased levels of B cell-intrinsic inflammation and these both correlate with lower B cell function.
We also found that FOXP1 acts as a tumor suppressor in prostate cancer through inhibiting cell proliferation and migration.
We also found that gene expression of HS3ST1 and ECHDC3 was altered in AD brains compared with control brains.
We also found that glycogen synthase kinase @number@ ( GSK3 ) regulated amyloid-β-mediated tau phosphorylation.
We also found that IF decreased plasma insulin levels ( @number@ μU / mL ) .
We also found that in the trajectories of depressive symptoms between elderly male and female across four waves of data , the results were heterogeneous.
We also found that neurogenesis markers increase in response to injury in regenerative but not in non-regenerative animals.
We also found that PBMCs , in turn , significantly promote the proliferation and differentiation of hNSCs.
We also found that public facilities tend to care for residents with more demanding characteristics : notably cognitive impairment , aggressive behaviours , and incontinence.
We also found that recent drug development in hematological malignancies has focused on molecular-targeted agents.
We also found that sgf73Δ mutants display altered acetylation of Ifh1 , an important regulator of RP gene transcription.
We also found that the A-670G polymorphism was related to patients with AD who carried the apolipoprotein-E ε4 allele in three genetic models.
We also found that the decreased level of @number@ hmC in non-tumor tissues was associated with tumor recurrence in the first year after surgical resection.
We also found that the genotypes of miR-146a rs2910164 were associated with its mature miRNA expression by analyzing @number@ PBMC samples from CAD patients.
We also found that the ICC values for AE were substantial for knee flexion and hip abduction of the left and right leg.
We also found that the length of experience ( adjusted for workplace and education ) did not have any impact on nurses ' knowledge.
We also found that the manifestation of skin aging is further modified by anatomical site.
We also found that there was a potential gene-gene interaction between rs405509 and rs1805192.
We also found that the TH microsomal fraction content decreases after inhibition of cyclin-dependent kinase @number@ ( Cdk5 ) and ERK1 / 2.
We also found that vascular pathology may be associated with memory impairment and may be difficult to distinguish from clinical Alzheimer's disease.
We also generated mouse and human ORF1p-specific antibodies to characterize the expression of ORF1p fusion proteins used in the M2H system.
We also handsearched systematic reviews , references , and clinical-practice guidelines.
We also have investigated the secular trends in the hip fracture incidence from 1985-2010.
We also highlight how alterations in epigenetic factors and mechanisms are being linked with sleep-wake disorders.
We also highlight important future research directions that may be fruitful for psychologists to pursue in this area.
We also highlight important methodological considerations that may affect data interpretation.
We also highlight key molecular events underlying the process of cellular reprogramming and discuss inherent features of iPSCs , including genome instability and epigenetic memory.
We also highlight the importance of overall quality and composition of the diet to protect against AD and dementia.
We also highlight the need for individual , family , and community level interventions to promote healthy aging among Chinese older women.
We also highlight the role that academic-community partnerships played in the outreach and recruitment process for our studies.
We also hypothesized that older individuals would be more sensitive to this effect and that the chronic CORT administration would exacerbate age-related memory decline.
We also hypothesized that people with higher purpose would spend fewer nights in the hospital.
We also hypothesized that seladin-1 might be a mediator of the neuroprotective effects of estrogens.
We also identified a miR-124 binding site in the @number@'-UTR of RFX1 mRNA and a RFX1 binding site in the first intron of ApoE gene.
We also identified a subgroup of control subjects with brain structure and cognitive changes highly similar to those observed in AD.
We also identified consistent and inconsistent attendees of the Booster Break sessions.
We also identified fifty-six papers dealing with sex differences in adiposity , insulin resistance and hormonal regulation.
We also identified four known mutations - three in ASPM and one in WDR62.
We also identified multiple , novel genomic regions that we hypothesize may contain causative risk variants that influence susceptibility to ALS.
We also identified that intracellular Aβ localized at telomere , and induced cell senescence and telomere shortening.
We also identified the impact of miR-125b on apoptosis in a lens epithelial cell line.
We also identified the neuronal substrates responsible for FAB performance.
We also identified twelve publications for CV mortality , which provided @number@ female and @number@ male ES estimates.
We also identified WIG1-binding motifs using photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation analyses.
We also identified young childhood as a stage of heightened interindividual variability.
We also identify how the field should adapt to best take advantage of coming opportunities and prepare for challenges.
We also identify @number@ distinct blocks or clusters of trans-eQTLs , each targeting the expression of sets of six to @number@ distinct trans-eGenes.
We also identify several gaps in knowledge and unanswered questions pertaining to iron homeostasis and immunity in obese populations.
We also identify the main senescence markers that may be used to recognize molecular alterations in the extracellular matrix of cartilage as related to senescence.
We also identify the QKI-6 isoform as a new component of stress granules in glial cells.
We also implemented a HL7 messaging interface for interoperability of clinical data exchange.
We also indirectly evaluate the algorithm with a experiment in which we study the atrophy of the brainstem in aging.
We also inquire whether coresidence transitions vary by older adults ' gender and the presence of grandchildren in skip generation households.
We also intra-compared the five states in group A and the five states in group B for the @number@ Hz and @number@ Hz frequencies.
We also introduced epoxy groups in the prenylation sites of the proteins to make them more hydrophilic and enrichable from complex samples.
We also introduce our results obtained as part of the Yamagata Study ( Funagata ) , a population-based epidemiologic study.
We also investigated anthropometric parameters , blood pressure ( BP ) , lifestyles and blood examinations.
We also investigated a polymorphism ( rs4073366 G > C ) that was @number@ bp from insLQ.
We also investigated a potential link between SCN1A and mI.
We also investigated deaths from all causes , circulatory disease , neoplasms , and external causes.
We also investigated how the different inflammatory environments related to intercellular and intracellular changes.
We also investigated how these factors interact.
We also investigated if the \ "relative preservation \ " concept is consistent across the individual sub-regions of the limbic system.
We also investigated morning erection as well as the presence and duration of erectile dysfunction ( ED ) .
We also investigated racial as well as FMR1 associations with menarcheal age in these donors.
We also investigated sex-specific associations between air pollution and biological aging , given the published association between sex and aging measures.
We also investigated the diagnostic capacity of CEA and CA15-3 for the early detection of metastatic breast cancer comparing that of Trx1.
We also investigated the effect of insomnia on intracortical motor excitability measures reflecting GABAergic and glutamatergic mechanisms.
We also investigated the effect of RJ ( @number@ mg / kg per day ) administration using a mouse model of dry eye.
We also investigated the impact of aging on these processes.
We also investigated the independent association between these markers and interstitial fibrosis using multiple linear regression analysis.
We also investigated the influence of age and sex on these parameters , as well as set a typically developing baseline for future comparisons.
We also investigated the interaction of PF and AVF with age regarding the atherosclerotic burden.
We also investigated whether any association could be explained by midlife weight and whether cognitive decline was associated with changing leptin levels.
We also investigated whether life satisfaction and positive affect showed similar patterns.
We also investigated whether single nucleotide polymorphisms ( SNPs ) in miRNA-processing genes modify these associations.
We also investigated whether the number of years working in general practice is a determinant factor associated with the responses obtained.
We also investigated whether there were differences in functional outcome and recanalization rates between them.
We also investigate the effects of the cornea's and lens's curved structures on the focusing mechanism.
We also investigate the empirical bias of estimators arising from a joint likelihood when the population covariate distribution is misspecified.
We also issued a questionnaire for @number@ patients and direct caregivers to further elucidate the natural history of the disease.
We also knocked down or overexpressed PGC-1α and FoxO3A by small interfering RNA or plasmid DNA transfection , respectively.
We also know much more now than we did @number@ years ago about the underlying neural mechanisms of these changes.
We also looked into their close relationship with SBI in this review.
We also make an inventory of knowledge about the effects of age and neurodegenerative diseases on social cognition.
We also measured BA responses to @number@ min of upper arm occlusion at rest and during @number@ h of leg IPC.
We also measured changes in these parameters under the influence of eating gerodietetic meat pate.
We also measured spinal white matter pallor.
We also measured the sensitivity / specificity of the method , and verified a correlation with cognitive performance.
We also measured trans-epidermal water loss ( TEWL ) in the same groups.
We also measured user-experience and time saved compared to manual countings.
We also modeled population-level trends among the @number@ participants with any data using proportionate percentile models , accounting for clustering through robust standard errors.
We also need to understand why , compared to other placental mammals , the human placenta is so variable in its morphology and functional capacity.
We also normalize the data at the device level to ensure that the magnitude of the signal at rest is similar across devices.
We also noted the formation / disruption of CpGs ( tentative methylation sites of epigenetic sSNPs ) .
We also noticed that they delivered babies more often than those in the control group.
We also observed a gender-specific characteristic , wherein the gastrointestinal motility of the young women was likely only influenced by postural change.
We also observed a loss of MCs , IMEs , and sudomotor nerves.
We also observed altered ubiquitin immunoreactivity in the double transgenic animals , suggesting that ubiquitin modification might be important for the observed improvements.
We also observed an interaction with statin use , which was statistically significant for sVCAM-1 and suggestive for sICAM-1.
We also observed a @number@ ( @number@ @number@ ) %5 mC difference in Alu methylation per @number@ cm of height.
We also observed associations between methylation and weight changes.
We also observed a strong correlation between telomere length and subtelomeric methylation status of HF cells.
We also observed decreased life span among adults that survived CB exposure.
We also observed improvements in balance control and postural stability with @number@ wk of training with the apparatus.
We also observed increased WRN promoter methylation in the cells of patients and decreased messenger WRN RNA ( WRN mRNA ) expression.
We also observed , in osteoporotic subjects , a lower muscle strength ( p-value = 0.023 ) .
We also observed lower overall variability in DNA methylation in the Nicoyan population , another hallmark of younger biological age.
We also observed severe liver inflammation in aged rats as indicated by increased ALT levels in serum and increased Kupffer cells in the liver.
We also observed significant associations between increases in temperature variability and mtDNA lesions independent of mean air temperature.
We also observed that E-AP-SM2001 effectively reduced melanin production by B16 / F10 melanoma cells and mushroom tyrosinase activities.
We also observed that long-term transgene expression occurred in astrocytes as well as neurons.
We also observe it in spite of the damaging effect of reactive oxygen species which may be even more than in normal cells.
We also observe that the degree of elevation in breast diminishes with advancing age.
We also obtained a positive patient feedback through the self-assessment questionnaires.
We also obtained participants ' scores on a battery of standard psychometric tests.
We also offer an overview of current diagnostic , treatment and management strategies for PJI.
We also performed a multivariate analysis to examine correlations between whole-brain activation patterns and behavioral performance in a face-matching task tested outside the scanner.
We also performed an epigenome-wide analysis to identify CpG methylation sites associated with HIV infection.
We also performed detailed spectral analyses of group-representative response data for each of the five overall excursion amplitudes.
We also performed functional enrichment on the common network and identified high association with phenotypic alteration.
We also performed neuropsychological measures of executive function for comparison.
We also performed volumetric analysis which revealed no significant structural differences between groups.
We also pilot tested the proposed means of verification.
We also present a summary of the proposed mechanisms for these associations.
We also present data about how they direct their health-related activities towards meeting their physical and psychological goals of being healthy.
We also presented the time trends of COPD between @number@ and @number@ by age , gender and setting ( urban vs rural ) .
We also present evidence that PGRN is a macrophage antiviral cytokine.
We also present sex-specific percentile curves for LM-age and LMI-age relationships , which could be useful for identifying the LM deficits in this population.
We also present the mechanisms that may induce steepening , as presented in the literature.
We also present the strengths and limitations of this concept.
We also present U-versions where the growth-rate parameters return absolute growth rate ( instead of relative ) .
We also probed participants ' associative recognition for face-place pairs post-task.
We also propose a hypothesis for why mechanisms underlying inflammation-induced hypertension are sex-specific.
We also propose a pathway by which exercise-induced alterations in immunosenescence may decrease the incidence of cancer and help improve prognosis in cancer patients.
We also propose a simple decision algorithm for the nutritional assessment of elderly patients with HF.
We also propose how such methods may be operationalized.
We also propose model organisms such as eusocial honey bees in which degeneracy can be studied at the molecular and cellular level.
We also propose new \ "unified \ " versions ( U-versions ) of both the traditional Ti -form and a simplified W0-form.
We also propose that an alternative concept of termination be considered , one that includes the possibility of post-termination follow-up contacts between patient and analyst.
We also propose that COX- @date@ act as an intrinsic biological aging clock due to its role in balancing inflammatory and anti-inflammatory responses.
We also provide a description of the core components of this innovative memory care program.
We also provide an overview of how each antidepressant presents a particular sex-differentiated pharmacokinetic profile.
We also provide an update on the progress of identifying longevity-mediating lipid genes , describe approaches to discover longevity genes , and discuss possible limitations.
We also provide detailed protocols developed or refined in our lab over the past two decades.
We also provided preliminary findings that suggest a link of LTL through genetic mechanisms with UVR and melanoma in the general population.
We also provide evidence that the fetal T cell lineage is biased toward immune tolerance.
We also provide information for the therapeutics in neuronal disorder in the perspective of MMP regulation.
We also provide instructions for downloading and using the new reaction time programme , and we encourage other researchers to use it.
We also provide perspectives on scientific and clinical questions that need to be addressed in the near future.
We also provide software for estimating and exploring this composition confounding for the Illumina 450k microarray.
We also provide some examples of successful uses for iPSC-based screens and suggest that additional development could revolutionize the field of drug discovery.
We also provide strong evidence that p62 / SQSTM1 associates with proteasomes and that autophagy degrades p62 / SQSTM1.
We also quantified @number@ measure of graph entropy ( diversity ) to measure the variability in connection strength ( edge weights ) at each node.
We also reanalyzed previous data from genome-wide association studies ( GWAS ) on the same cohort.
We also recommend potential measures across different levels of impact.
We also recorded gait parameters using an accelerometer , while balance and stability were assessed by stabilometric platform with open and closed eyes.
We also recorded new fractures , medical complications and anti-osteoporotic treatment compliance.
We also reflect on why cardiovascular risk may differ between the sexes by highlighting sex-specific variation in the age-associated remodeling process.
We also related these differences to clinical symptom severity.
We also rely on an independent series of findings to suggest how the traffic jams can act as a unified mediator of downstream pathophysiology.
We also replicated associations in CLU , PICALM , and BIN1 in the Caribbean Hispanic cohort.
We also replicated genetic associations for CLU , PICALM , and BIN1.
We also report changes in mitochondrial Hba and Hbb levels in ageing brain and muscle.
We also reported a patient with NMO accompanied with Sjögren syndrome.
We also report some recent definitions of osteoporosis and sarcopenia that have emerged in the literature and their implications in clinical practice.
We also report the psychometric properties of this assessment.
We also report the results of two pilot studies conducted as part of developing the message formats.
We also respond to critiques about model identification and theoretically-imposed constraints , finding little pragmatic support for such arguments.
We also retained the term possible AD dementia , but redefined it in a manner more focused than before.
We also revealed that PIM-1 interacts with and phosphorylates heterochromatin protein 1γ ( HP1γ ) on Ser93.
We also revealed the difference of the involved sites.
We also review and evaluate a decision making process that emergency physicians confront when faced with such a challenging and unusual situation .
We also review early evidence to suggest that the aged lung may be particularly susceptible to viral-induced fibrosis and make recommendations for future research directions.
We also reviewed guidelines for pain management.
We also reviewed literature regarding the effects of rTMS on cognitive function in AD.
We also reviewed the bibliographies of relevant citations to identify additional citations.
We also reviewed the reference lists of retrieved articles and gray literature was excluded.
We also review evidence that these E2 signaling mechanisms change with age.
We also review optimizing strategies aimed at medication adherence focusing on complex elderly patients.
We also review our own recent data on trafficking of innate immune subsets between primary and secondary lymphoid organs in heterochronic parabiosis.
We also review recent data in support of and against the emerging role of the UPR ( mt ) during aging and longevity.
We also review the autocrine effects of irisin in skeletal muscle , in which it upregulates the expression of its precursor ( FNDC5 ) .
We also review the current literature about the impact of lifestyle on microglia responses and discuss treatment options that modulate microglial phenotypes.
We also review the current trend in preoperative nutrition away from preoperative fasting and towards carbohydrate loading.
We also review the effect of inflammation on wave reflections.
We also review the existing telemedicine studies which include diagnosis and management of AMD , and how automated disease grading could benefit telemedicine.
We also review the literature of cases of fractured cemented and uncemented knee replacements and discuss the causes proposed.
We also review the mechanisms underlying the gradual decay of HPC dependency during systems consolidation from the perspective of memory erasures by adult hippocampal neurogenesis.
We also review the use of molecular inhibitors as therapeutic targets in AD.
We also screened geriatric syndromes at baseline and @number@ year later.
We also screened @number@ patients with early-onset parkinsonism without intellectual disability and @number@ normal controls of Japanese origin for WDR45 mutations.
We also searched ALOIS , the Cochrane Dementia & Cognitive Improvement Group's specialised register of dementia studies ( @url@
We also searched for the effect of testosterone replacement on the metabolic profiles of this specific patient group.
We also searched grey literature for additional citations.
We also searched the reference lists of identified articles for additional papers and sought expert opinion on relevant studies.
We also showed that HDAC7 decreased via ubiquitin-dependent degradation.
We also showed that the 8-oxodG-incision activity of OGG1 is similar in telomeric and non-telomeric double-stranded substrates.
We also showed that the elevated level of heme degradation in HbCC cells that is attributed to increased oxidative stress was found on the membrane.
We also show how the latter two can be converted into standard visual psychometric thresholds.
We also show that AD and PD have a statistically significant association with the gait speed and sit-to-stand test performance.
We also show that all four hnRNP D isoforms can act as genuine splicing repressors when bound to exonic positions.
We also show that breast cancer ( BC ) cells display elevated ADAR1 but not ADAR2 levels , compared to nontumourigenic cells.
We also show that mTORC1 signaling is required for the essential amino acid ( EAA ) -induced increase in MPS.
We also show that overexpression of miR-141 induces premature senescence in HDFs via targeting of BMI1 in normal but not in exogenous BMI1-overexpressing HDFs.
We also show that overexpression of serine palmitoyltransferase to elevate de novo sphingolipid biosynthesis induces autophagy in the liver.
We also show that protection from oxidative stress is increased upon eIF4A inhibition.
We also show that the human cerebral cortex contains tetraploid neurons.
We also show that the hyperspherical wavelet successfully picks up group-wise differences that are barely detectable using SPHARM.
We also show that there is an absence of consistent predictors of physical stature decline at the individual level.
We also show that TP53 regulates truncation through induction of the mitochondrial protein Mieap.
We also show that transcripts encoding this unique N-terminal stretch are expressed in the human brain , with highest production in the cerebellum.
We also show that wild-type BMI1 but not the mutant BMI1 interacts with βTrCP.
We also simulate a clinical scenario of prediction on multiple categories , where trajectories predicted from multiple models are classified based on maximum likelihood criteria.
We also speculate on the involvement of lamins in tumor cell proliferation through the control of ROS metabolism.
We also speculate that intervention to prevent these aberrant S-nitrosylation events may produce novel therapeutic agents to combat neurodegenerative diseases.
We also stratified by TBI severity and age category ( 55-64 , 65-74 , 75-84 , and ≥85 years ) .
We also studied a more personalized approach , by psychiatric diagnosis and gender , with a focus on bipolar males , the highest risk group.
We also studied how individual parameter impacted sRAGE autologous expression in CHO cells , and whether sRAGE bioactivity was compromised.
We also studied @number@ non-demented participants who completed neuropsychological testing in @number@ and received a diagnostic assessment in @number@ ( n = @number@ ) .
We also studied @number@ ) the ages at which AP , AR , pubertal TO and pubertal PHV occurred.
We also studied the effects of a 4-week training cessation ( 'detraining' ) period on our study variables.
We also studied the effects of childhood and recent psychological distress on telomere length.
We also studied the localization of EAAT1 and EAAT2 using immunohistochemistry in @number@ essential tremor cases and @number@ controls.
We also studied this STR in a sample of @number@ Iranian human subjects that encompassed a number of neuropsychiatric disorders and controls.
We also suggest future areas where DTI is likely to have significant impact.
We also suggest possible measures and tools to better test for selective attention in AD.
We also suggest that emerging biomarker-based diagnostic tools may be useful in further characterizing diverse populations with AD.
We also summarize current data on the effect of Asp isomerization on lens crystallins.
We also summarize some of the main metabolic targets for treatments.
We also summarize very recent genome-wide association studies on risk gene polymorphisms in the emergence of PD.
We also suppressed eEF1A2 expression using RNA interference and then analyzed cell proliferation , migration and invasion of five adenocarcinoma cell lines.
We also surmise that mitochondria and chloroplasts may be primary sites of melatonin synthesis in all eukaryotic cells that possess these organelles.
We also tested for age changes in the parameters of the process S exponential decline.
We also tested in this cohort of older adults a recently published algorithm determining chronological age based on DNA methylation profiles.
We also tested several potential mechanisms.
We also tested the association between the candidate single nucleotide polymorphism and @number@ postmenopausal women.
We also tested the effect of physical inactivity in the development of frailty as determined by our score.
We also tested the hypothesis that age-related impairments on the MST could be modeled within a global matching computational framework.
We also tested the idea that skin wrinkling has an impact on tactile acuity or vibrotactile sensation using two independent sensory tasks.
We also tested the moderating role of interdependent self-construal in the relationships.
We also tested the subjects from LBC1936 for previous genome-wide WMH associations found in subjects from CHARGE.
We also tested the underlying molecular biology concerning the proliferation- and apoptosis-regulating gene expression alterations.
We also tested to what extent these emotion regulation strategies were useful for each age group in managing response to age-relevant sad information.
We also tested trial-to-trial modulations of plausibility-checking strategies , and aging effects on these sequential modulations.
We also tested whether changes in VA mediated exercise effects on performance on various cognitive tasks.
We also tested whether the HbA1c-hypoglycemia association differed across potential effect modifiers ( age , diabetes duration , and category of diabetes medication ) .
We also tested whether the ε2 allele was associated with disadvantages in early adulthood but offered protection against cognitive decline in early old age.
We also test whether these associations differ significantly by sex.
We also touch on the few studies using functional neuroimaging and connectivity analyses that further implicate the cerebellum in age-related performance declines.
We also tried to develop and validate a new frailty index based on a multidimensional model.
We also updated the current status of clinical trials using neurotransmitters ' agonists / antagonists in AD.
We also used a divided attention condition in older adults as a possible model for the deficits observed in MCI patients.
We also used fruit flies as a model for analyzing the anti-aging property of PKCF.
We also used indirect calorimetry as a continuous measure of metabolic heat production.
We also used logistic regression to calculate odds ratios for each risk SNP , comparing fatal PCa cases to controls.
We also used parasites with disrupted EBA140 , EBA175 and EBA181 genes to show that all these were targets of invasion inhibitory antibodies.
We also used quantitative proteomics to demonstrate re-wiring of the cyclin E interactome upon ablation of Cdk2.
We also used web-based resources in regards to the FMR1 gene and reviewed additional citations from reviewed publications.
We also use multiphoton imaging of ANS binding to follow the in vivo recovery of cells from protein-damaging insults over time.
We also varied the cutoff scores at which impairment was recognized and examined whether this altered inclusion in MCI subcategories.
We also verified that the miR-377-mediated changes in p53 expression could be reversed by regulation of DNMT1 in HSFs.
We also wanted to investigate whether cancer morbidity among HHT patients differs from that among controls.
We also wish to further our mission of leading the forum to progress the science and practice of translational research in alcoholism.
We amid to explore the role of TUG1 and miR-421 in the age-related cataract.
We analysed 450K methylation array data using a machine learning approach ( GLMnet ) to identify age-associated CpGs.
We analysed data from @number@ participants : @number@ mutation carriers ( @number@ symptomatic and @number@ asymptomatic ) and @number@ non-carriers.
We analysed data from @number@ runners ( @number@ women and @number@ men ) competing between @number@ and @number@ in GöteborgsVarvet , the world's largest half-marathon.
We analysed demographic data , severity and subtype of stroke , risk factors , including the presence of hypercoagulable states , and outcome.
We analysed each study separately using linear and logistic regression models and then used meta-analytic methods to pool the results.
We analyse differences between the two perspectives using mortality models , historical data , and forecasted data.
We analysed @number@ consecutive patients , who underwent coronary arterial computed tomographic angiography.
We analysed the influence of age , sex and HCMV seropositivity on each lymphocyte subpopulations and established reference ranges.
We analysed the proteins of RBC ghosts obtained from our subjects before and after returning to sea level by two-dimensional electrophoresis and mass spectrometry.
We analysed the use of bisphosphonates , raloxifene , and calcium / vitamin D combinations in relation to clinically based dementia diagnosis.
We analyzed and compared tumor location , extent of tumor resection , adjuvant treatment , and clinical course in all patients.
We analyzed associations of AGE with ART outcomes and pre-ART clinical factors.
We analyzed a subgroup of @number@ SNPs that were in low linkage disequilibrium with each other.
We analyzed a total of @number@ adult males from four datasets with information on diurnal type and age.
We analyzed biomarker data collected at baseline , 12- , and 24-month follow-up assessments.
We analyzed by pulse-chase assays , whether cellular signaling can affect hδOR ( Cys27 ) maturation.
We analyzed changes over time and used hierarchical logistic regression to adjust for potential confounders.
We analyzed circulating sclerostin in @number@ men with varying degrees of SCI who were @number@ year or more post-injury.
We analyzed cumulative data ( @number@ samples in accumulated total ) using generalized estimating equations.
We analyzed data from a prospective longitudinal study to test whether becoming obese was associated with intellectual decline from childhood to midlife.
We analyzed data from @number@ bereaved family members of hospice patients.
We analyzed data of @number@ non-diabetic Koreans using fasting plasma glucose ( FPG ) criteria and HbA1c criteria in screening for diabetes.
We analyzed data on @number@ male participants in the Veterans Aging Cohort Study-Virtual Cohort who were free of baseline cardiovascular disease.
We analyzed factors associated with the development of pressure ulcers in patients hospitalized in a palliative care ward setting.
We analyzed factors associated with these transitions , including the use of cigars and smokeless tobacco ( SLT ) .
We analyzed favorable outcome , successful and futile recanalization , neurological improvement , in-hospital complications , and mortality in both groups.
We analyzed gene expression changes in @number@ postmortem central nervous system regions , stratified by severity of motor neuron loss.
We analyzed hair diameter , AFM images of the hair surface , cuticular descriptors and micro-scale mechanical properties for their associations with aging.
We analyzed hip dual-energy X-ray absorptiometry images acquired longitudinally over @number@ years for @number@ midlife women transitioning through menopause.
We analyzed how patient age affected the angiogenic properties of ADSCs.
We analyzed HR time series , a neuroautonomically regulated signal , during sleep , using the multiscale entropy method.
We analyzed intra- and interindividual white matter alterations variations and their relationship with quality of biochemical control and cognitive outcome.
We analyzed leukocyte TL in @number@ SZ patients of Hispanic ancestry grouped based on antipsychotic treatment , compared to @number@ matched controls.
We analyzed medical information , demographic characteristics , and interviewer-administrated questionnaires , as well as verbatim transcripts of interviews.
We analyzed @number@ adult fasting participants without cardiovascular disease and without lipid-lowering drug use.
We analyzed @number@ genome-wide association studies comprised of @number@ individuals of African ancestry , and validated our results with additional @number@ individuals from multi-ethnic studies.
We analyzed @number@ \ "normal \ " patients in whom kidney shear wave speed was assessed by means of ARFI elastography.
We analyzed @number@ patients with SMID.
We analyzed overall QOL relative to participation in activities after adjustment.
We analyzed patterns of utilization of screening colonoscopy in Medicare enrollees by using estimated life expectancy.
We analyzed reported illness , self-perception of health status and medicine consumption.
We analyzed scores as individual questions and in defined topic domains using a paired student t test.
We analyzed self-report data and electronic medical and pharmacy record data from @number@ participants in the Veterans Aging Cohort Study.
We analyzed seventeen elderly RRTI patients and matched controls.
We analyzed sociodemographic characteristics , self-perceived health status , lifestyle habits , and comorbid conditions using multivariate logistic regression models.
We analyzed the association between different types of leisure time activity at baseline and cognition more than @number@ years later.
We analyzed the association between indicators and all-cause admission to hospital , fracture-specific admission to hospital and death using generalized estimating equations.
We analyzed the available data from @number@ elderly people in the Korean Longitudinal Study on Health and Aging.
We analyzed the correlations between ALP levels and bone metabolic markers or hepatic function markers.
We analyzed the data of @number@ healthy residents in the town of Ohasama aged @number@ years and over who had completed self-administered questionnaires.
We analyzed the data using a generalized linear model with a gamma distribution and log link.
We analyzed the data using multivariate linear regression and linear mixed models.
We analyzed the data using multivariate regression models.
We analyzed the data using Student's t-test or χ ( @number@ ) -test.
We analyzed the distributions of response times ( RT ) for repeating real words and pseudowords during fMRI.
We analyzed the free flap types and donor site , flap , and postoperative systemic complications.
We analyzed the literature and present patient data from our institution.
We analyzed the medical records of outpatient treatment of the above.
We analyzed the possible interactions between neuropsychological pattern and clinical , demographical , and genetic variables.
We analyzed the relationship among cognitive performance , anthropometry , and functional capacity in institutionalized elderly individuals.
We analyzed the relationship between coronary atherosclerosis , quantified by coronary calcium in CT , epicardial fat volume and systemic inflammation.
We analyzed the rsFC patterns of the right anterior insular cortex ( rAI ) , a primary node of the SN.
We analyzed these variables with the 4-segment Oxford foot model.
We analyzed the SNPs for association with refractive error using standard regression methods in PLINK.
We analyzed the Studies Of Left Ventricular Dysfunction limited data set ( n = @number@ ) .
We analyzed the three silent loci where normally Sir2p acts : ribosomal DNA , telomeres and the mating type loci.
We analyzed this model for both the total sample and the subpopulation aged @number@ years or older.
We analyzed to what extent both methodologies yielded different results in terms of granularity and biological congruency.
We analyzed WCRF / AICR recommendations in cohorts of European and U.S. adults ages @number@ years and above.
We analyzed whole-genome sequence data from families affected by Alzheimer disease to illustrate the application of the RV-GDT.
We analyze here the relation between alternative splicing and gene duplication in light of recent genomic data , with a focus on the human genome.
We analyze these dynamics in terms of power dependencies , interest dissatisfaction and value commitments.
We and others have demonstrated that aerobic exercise acutely and chronically alters protein metabolism and induces skeletal muscle hypertrophy.
We and others have focused on clarifying the age-related changes in human skeletal muscle mitochondrial function in vivo.
We and others have identified S-adenosylhomocysteine hydrolase in a high-throughput genetic screen focused on discovering novel genes whose inhibition induces immortalisation of primary cells.
We and others have previously shown that testosterone replacement therapy ( TRT ) results in sustained weight loss in the majority of middle-aged hypogonadal men.
We and others have reported that small vessel diseases affect cognitive function in older diabetics.
We and others have shown that the immediate function of endothelial cilia is to sense extracellular signal.
We anticipate continuing socioeconomic disparities in life expectancy.
We anticipate that this review will motivate multi-disciplinary research on the BBB aiming at the design of effective drug therapies.
We anticipate this framework will be useful for research prioritization and intervention development.
We applied a computational method to objectively generate service boundaries for such endovascular clot retrieval hubs , defined by traveling time to hub.
We applied a decision matrix to yield the final 11-item version.
We applied a feedback-based learning task with two learning conditions.
We applied a multivariable hurdle model to investigate the association of physical activity and disability.
We applied analysis of variance and bootstrapping statistical procedures.
We applied a novel , automated method for measurement of hippocampal subfields and extrahippocampal MTL cortical regions.
We applied attachment theory to understanding caregiver depression , and both potentially harmful and exemplary caregiving responses.
We applied a validated algorithm to identify people with HIV among all residents aged @number@ years or older between @date@ and @date@ .
We applied a Weibull multivariable regression.
We applied a willingness-to-pay threshold of $ 100 , 000 per quality-adjusted life-year ( QALY ) gained.
We applied bioinformatics approaches to analyze the network topology and to prove that the network is not random , but exhibits biologically meaningful properties.
We applied city-specific time-series Poisson regression models and pooled them with random-effects meta-analysis.
We applied computational surface-based mesh-modeling methods to analyze callosal morphology at extremely high spatial resolution.
We applied different fixation and postfixation solutions to preserve cell shape , proteoglycans , and membranes.
We applied Diffusion Tensor Imaging ( DTI ) to determine the topography of neuronal networks underlying Stroop interference under control of general slowing.
We applied disability weights proposed by the National Osteoporosis Foundation and did a series of sensitivity analyses to examine the robustness of DALY estimates.
We applied droplet digital polymerase chain reaction in CSF specimens from @number@ patients representing the AD spectrum and @number@ neurologically healthy controls.
We applied EX-PRESS implants in @number@ patients with neovascular glaucoma ( NVG ) and in @number@ patients with non-NVG.
We applied FS-containing ACP to etched enamel surfaces.
We applied here strict criteria to identify adults lacking thymic activity based on sjTREC levels , to exclude thymic rebound and / or ectopic thymuses.
We applied joinpoint regression analysis for trend analysis.
We applied joinpoint regression analysis to identify trends.
We applied K-means cluster analysis to derive social network types using @number@ criterion variables.
We applied multi-parametric flow cytometry to a cohort of @number@ young ( 19-30 years ) and @number@ elderly ( 53-67 years ) healthy individuals.
We applied multiple regression analyses to estimate the correlation between TPV growth rate and age.
We applied our methods to GWAS summary-level data of @number@ complex diseases.
We applied PD to the raw and clinical display images as a standard for measurement comparison.
We applied principal component analysis ( PCA ) to @number@ inflammatory biomarkers from the InCHIANTI study.
We applied Prix fixe to select the putative causal genes underneath the GWAS peaks , which was based on underlying functional similarities.
We applied propensity score matching ( PSM ) to minimize confounding biases in the comparison between EOAD and LOAD.
We applied published biomarker algorithms to these data to calculate two biological age measures , Klemera-Doubal Method Biological Age and homeostatic dysregulation.
We applied random-effects meta-analysis to evaluate the effect of study features.
We applied [ Reactive oxygen species ( ROS ) play a major role in both chronological aging and photoaging.
We applied regression models controlling for demographic , health status and other factors to evaluate the association between 6MWD and EQ-5D-5L.
We applied spectral and transfer function analysis to quantify dynamic cerebral autoregulation and brain tissue oxygenation.
We applied such an approach on human primary keratinocytes obtained from sun-nonexposed skin biopsies of young and elderly women.
We applied the ACEt package to a Finnish twin cohort to investigate age-specific heritability of body mass index and height.
We applied the concept of fractal geometry and fractal dimension D analysis to describe heterogeneity within the bone structure.
We applied these rates to the population expected by the Census Bureau to exist through @number@
We applied the uncontrolled manifold analysis to decompose trial-to-trial variability in joint kinematics into variability that stabilizes and destabilizes task-important performance variables.
We applied this method to a cohort of well characterized clinical samples and observed the following findings.
We applied weighted linear regression to the matched data sets.
We apply a Foucauldian gerontology perspective as our analytical tool.
We apply a modern machine learning method , the support vector machine to establish a predicting model for the severity of OSA.
We apply a stochastic dynamics framework to illustrate that the average recovery time increases with age , mimicking the age-associated increase in deficit accumulation.
We apply event-related potentials to examine which cognitive subprocesses are affected by latent T. gondii infection on a neurophysiological level.
We apply Heckman-type corrections for selection bias due to mortality and marriage.
We apply our method to study the relation between smoking and high dimensional DNA methylation markers in the Normative Aging Study ( NAS ) .
We apply the method to a study of vitamin D and gait speed among older adults.
We apply the proposed method to two neuroimaging data examples.
We apply this methodology to colorectal tumorigenesis while considering life expectancy data of the US population to inform the dynamics of the aging process.
Wearable monitoring devices are rapidly becoming a recognized option in rehabilitation for quantitative measures.
We are about to be treating patients who either may develop a new CVD or their current CVD may deteriorate.
We are an international working group from the Centres of Excellence in Neurodegeneration.
We are as old as our adult stem cells are ; therefore , stem cell exhaustion is considered a hallmark of aging.
We are challenged to develop creative strategies to significantly reduce harm and fall rates among the elderly.
We are dealing with a present and future epidemic that will fundamentally affect health care provision in all high-income countries.
We are developing a microwave tomographic system for assessment of overall bone health.
We are exploring the stress hypothesis in which an acute stressor is used as the discriminator of frailty susceptibility.
We are getting closer to providing evidence-based recommendations on fish and fish oil intake to facilitate memory function during old age.
We are informing authors who have cited our paper in the past and apologize deeply for any wasted time or lost work.
We are interested in the role of ARG2 and the potential underlying mechanism ( s ) in modulation of endothelial autophagy.
We are living in an era of unprecedented aging , with over a billion older people expected to be alive within a few decades.
We are now trying to develop a SARM which may have beneficial effect on metabolic syndrome.
We are now undertaking preliminary testing of the programme.
We are of the opinion that ID of the PCoA only develops postnatally and probably is due to the influence of hemodynamic factors or hypertension.
We are overwhelmed by warnings about inevitable geophysical and human problems.
We are thus facing a new challenge especially considering incidence of cardiovascular diseases ( CVD ) in this patients population.
We are unaware of a study that has examined sleep deficits in ET across the full spectrum of cognitive presentations.
We are uncertain about effects on anxiety or social behaviour , and about any long-term effects.
We argue that current practices leave a significant minority of older foreign-born residents inconsistently covered or without any insurance.
We argue that efforts in three research areas must converge to harness the full therapeutic power of NTFs.
We argue that future DHS and other population-based HIV surveys should offer HIV testing to all adults without age limits.
We argue that improved care coordination is necessary to improve outcomes and \ "bend the cost curve downward. \ "
We argue that it is a worthwhile enterprise to further develop structural partnership relations between residents , volunteers and staff in residential care homes.
We argue that manifestations of aetiologically coherent traits should show similar age group differences.
We argue that memory games have potential for enhancing the cognitive ability of the elderly and improving their life quality.
We argue that more research is needed on negative family interactions and their implications for the mental health of older ethnic minorities.
We argue that narrative gerontology could profit from integrating a more cultural critical stance in its investigations.
We argue that prediction-based modeling of prison growth should more seriously consider the impacts and consequences of demographic shifts among older prisoner populations.
We argue that the age structure of early humans was robust in its balance of the juvenile , reproductive-age , and senescent classes.
We argue that the limit to lifespan may be approaching.
We argue that the mechanisms of plasticity change over the lifespan with different slopes of change in different individuals.
We argue that the previously reported cross-linguistic difference in the AoA effect resulted from a between-study difference in stimulus imageability.
We argue that the repressed telomerase was a response to a higher mutation load brought on by the evolution of homeothermy.
We argue that this approach may be misleading , because it confounds the time aspect with the mere change aspect of aging.
We argue that this learning specificity is due to a low training task variability.
We argue that training of this neural network may produce cross-modal effects on other behavioral or cognitive operations that draw on this network.
Wearing an immobilization device on the right lower limb minimally lengthens the emergency braking time in healthy drivers under actual driving conditions.
Wearing high heeled shoes has been implicated as a potential contributing factor for the higher lifetime risk of osteoarthritis in women.
Wear track volumes were characterized by confocal microscopy.
We ascertained two siblings with of ARCL II born to non-consanguineous parents.
We asked for stakeholders to provide input on governance of large biorepositories at the University of California ( UC ) , a public university.
We asked here whether consuming protein following exercise during aerobic training increases long-term protein and DNA synthesis rates in skeletal muscle of adult humans.
We asked participants in @number@ and @number@ whether they had smoked in the past @number@ days.
We asked participants of different ages to choose among electrical shocks that varied in timing and intensity.
We asked participants to reflect on their answers for list items in detail.
We asked stakeholders to provide opinions on the possibility of implementation of these guidelines within their LTC facilities.
We asked the participants to wear a pedometer every day and to report their daily steps using a mobile phone diary each night before retiring.
We asked the subjects to perform step-tracking movements of the wrist joint with a manipulandum , and recorded the movements.
We asked whether a decreased availability of astrocyte-derived factors may contribute to the age-related decline in neurogenesis.
We asked whether aged adults are more susceptible to exercise-induced pulmonary edema relative to younger individuals.
We asked whether injection of Cat316 into the perirhinal cortex would have the same effects on memory as chondroitinase ABC treatment.
We asked whether quiet standing is lateralized and whether the COP dynamics of the right and left legs differ.
We assayed serum soluble Brown adipose tissue ( BAT ) provides a means of nonshivering thermogenesis.
We assayed the effects of both sediment-bound and aqueous nickel upon animal growth , developmental survival , lifespan , and fecundity.
We assayed UVB-irradiated keratinocytes soluble signals , mainly IL-6 and reactive oxygen species ( ROS ) .
We assessed adherence to physician recommendations for surveillance in opportunistic CRC screening in Germany.
We assessed ADL disability using the 25-question Geriatric Locomotive Function Scale ( GLFS-25 ) , and psychological concerns by three self-reported questions.
We assessed advanced neurofibrillary ( Braak stages V and VI ) pathology focusing on nondemented individuals.
We assessed after-hours operations , length of stay , duration of operation , gender , comorbidities , and mortality.
We assessed age-associated methylation and expression levels for @number@ splicing factor genes , in peripheral blood samples from the InCHIANTI study.
We assessed arterial stiffness in obese adolescents and evaluated the relationship between intra-abdominal fat distribution and arterial stiffness.
We assessed association between the use of PPIs and the risk of dementia in elderly people.
We assessed attention to left and right peripheral probes using event-related potentials ( ERPs ) .
We assessed baseline perceived global control ( measured as @number@ dimensions- \ "constraints \ " and \ "mastery \ " ) , and health-specific control.
We assessed behavioral performance during associative learning in a group of SCZ , BD and healthy controls ( HC ) .
We assessed changes in C-index , integrated discrimination improvement ( IDI ) , and net reclassification improvement ( NRI ) for the multimarker approach.
We assessed CMBs on MRI and retinal microvascular signs on digital retinal images.
We assessed cognitive function using the Cognitive Ability Screening Instrument ( CASI ) .
We assessed cognitively healthy older adults with search tasks indexing processing speed and attentional control.
We assessed cognitive performance and CSF AD-biomarkers , and potential moderation effect of bilingualism on the association between age , CSF AD-biomarkers , and cognition.
We assessed comfort , safety and quality of endoscopy under moderate sedation after @number@ hours fasting for clear liquids.
We assessed cortisol from @number@ saliva samples paralleling individual diurnal rhythms across three non-consecutive days in a group of @number@ middle-aged twin men ages 51-60.
We assessed dementia risk associated with OI score ( by tertile ) using Cox proportional hazards models.
We assessed determinants of incident microbleeds in relation to their location with multiple logistic regressions.
We assessed differences in white matter microstructural integrity , hippocampal volume , subregional volumes , and cortical thickness and surface area of selected regions.
We assessed episodic memory and regional brain volumes , using 3T MRI , @number@ years later.
We assessed expression associations with MMSE performance at RNA collection and prior 9-year change in MMSE score in linear regression models.
We assessed generative concern , generative action , perceived rejection from younger people , and psychological well-being.
We assessed global cognitive function with the Mini-Mental State Examination at baseline and at 3- and / or 6-year follow-up.
We assessed hypertension prevalence , awareness , treatment , and control with blood pressure measurements and self-report data.
We assessed in patients with amnestic mild cognitive impairment ( aMCI ) whether higher CR moderates the association between low internetwork cross-talk on memory performance.
We assessed interactions between psychosocial predictors , and with APOE ε4 status.
We assessed language ability using a language test and cortical responses recorded during language processing using a word repetition task and functional near-infrared spectroscopy.
We assessed long-term exposure to traffic-related air pollution using a validated spatiotemporal land-use regression model for BC.
We assessed medical records for validated morphometric characteristics of aging ( psoas area , psoas density , and abdominal aortic calcification ) .
We assessed mid-life proteinuria and late-life cognitive function in elderly Asian men.
We assessed mitochondrial superoxide generation using MitoSOX Red.
We assessed mortality rates and clinical predictors of survival in patients with IS or transient ischemic attack ( TIA ) < 60 years.
We assessed @number@ clinic patients for frailty using the 5-measure Fried Frailty criteria.
We assessed @number@ non-demented Parkinson disease patients with detailed cognitive assessments and 18F-florbetapir PET brain imaging.
We assessed nutritional status with the Mini Nutritional Assessment ( MNA ) , and retrieved information on mortality from central registers on @date@ .
We assessed participants for level of myelomeningocele , administered questionnaires , conducted biological and environmental sample collection , and performed genotyping.
We assessed physical activity at the beginning and the end of the follow-up period.
We assessed PIR using the Barriers of Insulin Treatment Questionnaire ( BIT ) and the Insulin Treatment Appraisal Scale in a face-to-face interview.
We assessed PLPH in the Alzheimer's Disease Neuroimaging Initiative cohort and found that PLPH occurrence was reduced only when using a @number@ gauge atraumatic needle.
We assessed RELN promoter methylation in post-mortem temporocortical tissue ( Brodmann Area 41 / 42 ) of three prepuberal and six postpuberal normal individuals.
We assessed stakeholders ' views on the influence of urbanization on health issues faced and interventions for alleviating these challenges.
We assessed T₂ ( APP ) associations with T-scores , Harris Hip score and age.
We assessed the ACR reference values and the factors that affect them in a population of healthy Chinese children.
We assessed the appetite through the Hemodialysis Study Appetite questionnaire and xerostomia through the Xerostomia Inventory ( XI ) .
We assessed the association between HIV and incident AMI within CVDRF strata.
We assessed the association between renal and cognitive function based on an extensive battery of neurocognitive tests.
We assessed the association between the LDL GRS and LDL-C levels , chronological age , familial longevity and mortality.
We assessed the association of neurological disorders and signs with everyday functioning and prospectively analyzed their relationship with mortality.
We assessed the associations of questionnaire-assessed and accelerometer-assessed physical activity with adiposity markers in older adults.
We assessed the clinical benefits of @number@ mo of leucine supplementation in elderly , type @number@ diabetes patients.
We assessed the cross-sectional relationship between HIV serostatus , age , thigh muscle attenuation , and thigh muscle cross-sectional area ( CSA ) .
We assessed the effect of a 6-month exercise and recreation program on executive functions in adults with chronic stroke.
We assessed the effects of aging in the transfer of motor learning in a sequential manual assembly task that is representative for real working conditions.
We assessed the evidence for gene-based association of rare variants with AD in @number@ genes for which an association with such variants was previously claimed.
We assessed the expected diagnostic performance of combined application of FS and FIT.
We assessed the extent of aortic wedging by measuring the vertical distance between the non-adjacent aortic sinus and the inferior epicardium.
We assessed the Frailty Index in older HIV + Australian men on ART.
We assessed the frequency and caregiver distress associated with three dimensions of BPSD ( depressive , disruptive and memory problems ) .
We assessed the impact of adding the CSF data to the subject categorization according to the NIA-AA criteria.
We assessed the impact of age on responses to systemic immune stimulation.
We assessed the impact of sarcopenia on impairment in both aspects of functionality and the relative contribution of its components , muscle mass and strength.
We assessed the impact of updated 10-year risk scores by reclassification and C-statistics.
We assessed the incidence of patient falls during admission in nursing home in @number@ and @number@
We assessed their cardiovascular risk factors.
We assessed their predictive accuracy in terms of discrimination using the area under the receiver operating characteristic curve and calibration analyses.
We assessed the laboratory data and the telomere length parameters to determine any correlations.
We assessed the length , lobe number , and morphological classification of their LAAs.
We assessed the long-term renal complications in a regional cohort of extremely low birth weight ( ELBW ) children born in 2002-2004.
We assessed the performance of the models by calculating calibration and discrimination.
We assessed the predictive validity of frailty index by examining how well it predicted common aging-related outcomes including hospitalization , disability , and death.
We assessed the presence of lung disease , cardiac disease , peripheral atherosclerosis , stroke , diabetes mellitus , arthritis , and cancer.
We assessed the prevalence of frailty and association with anthropometric measures in HIV-infected and uninfected postmenopausal women.
We assessed the probability of hypertension in stepwise multiple logistic analysis , and awareness , and control of hypertension.
We assessed the proportion LTFU and used multivariable logistic regression to evaluate demographic and clinical characteristics associated with LTFU after the 22nd birthday.
We assessed the quality of IVR data collected from older respondents participating in a statewide falls prevention program evaluation in Pennsylvania in @date@ .
We assessed the quality of this non-randomized design by examining recruitment , follow-up across study groups , and comparability at baseline.
We assessed the relationship between ICD implantation and mortality by age , and an optimal age cutoff was estimated nonparametrically with selection impact curves.
We assessed the relationship between measures of adiposity and mortality in older adults.
We assessed the relationship of various biomarkers to CAC , specifically in HIV-infected individuals on potent antiretroviral therapy ( ART ) .
We assessed the risk associated with depressive symptoms for Alzheimer-type dementia and vascular dementia.
We assessed the SDPTG by d / a ratio , b / a ratio and aging index ( AGI ) .
We assessed the skin-related quality of life and patient satisfaction with skin appearance.
We assessed the study to have a high risk of bias.
We assessed the top anti-aging creams currently on the market specifically evaluating their botanical ingredients.
We assessed the validity of the MSQ by comparing the responses of patients ' bed partners with the findings on PSG.
We assessed this question for fall injuries leading to hospitalization.
We assessed underweight and overweight by urban residence across the lifespan in India.
We assessed whether a summary index measuring impairments across multiple physiologic systems was associated with slowed gait in older individuals.
We assessed whether expansion size is associated with disease severity or phenotype.
We assessed whether klotho concentrations measured at the 3-year visit related to cognition and cognitive decline.
We assessed whether patients were aware of their eye condition based on a previous diagnosis by a physician.
We assessed whether polymers of N-acetylglucosamine ( GlcNAc ) have any pathogenetic role in Alzheimer's disease ( AD ) .
We assessed wisdom using self-report , performance , and nomination approaches.
We assessed women's preferences for involvement in decision-making , primary treatment decision maker , and participatory decision-making.
We assess forward-backward differences in protective steps in a young and elderly group.
We assess orthostatic hypotension ( OH ) prevalence in elderly fallers and determine OH-associated risk factors in this patient population.
We assess our findings in light of the ADHD-200 classification competition , and contrast our unsupervised , nominated topics with previously published supervised learning methods.
We assess present practice in the team , and make recommendations.
We assess this technique using statistical and bioinformatics analyses of microarray data to establish the limitations of the method.
We asses the relationship between nutritional status and indicators of functional capacity among recently hospitalized elderly in a general hospital.
We assigned to each parameter a score system based on a graduated scale.
We associated the prevalence of advanced colorectal neoplasms with time since negative colonoscopies.
We assumed a temporally stable relationship between depressive symptoms and obesity and , thus imposed equality constraints over time.
We assumed that the variance of DFA scaling exponent arises due to individual differences , time series length , and experimental error.
We assumed that topical nifedipine was able to relax mimic muscular fibres in the same way , thus reducing the depth of wrinkles.
We assume that the identified molecular determinants may be prioritized for further screening as novel drug targets to cure multiple ARDs.
We assume that the mitochondrial aging mechanism is similar to the mechanism of aging of the immune system which we discuss in detail.
We assume that the test values and their classification accuracies are dependent on covariates.
We assume that this allowed both groups to maintain performance under dual-task conditions , leading to minimal dual-task interference.
We attempted to address some practical questions that are relevant to the daily practice of clinicians.
We attempted to clarify myocardial telomere dynamics using samples from @number@ autopsied patients using Southern blot analysis.
We attempted to clarify the relationship between oxidative stress and Aβ in vitro.
We attempted to compare the effectiveness of HIV treatment delivered at community versus hospital care settings.
We attempted to determine the risk factors for new-onset diabetes in ≥53-year old Taiwanese.
We attempted to examine the decline in muscle mass , grip strength and gait speed in a cohort of older Chinese prospectively over @number@ years.
We attempted to examine the rate of these transitions and their associated factors.
We attempted to examine the sensitivity and specificity of each of the five Fried's criteria as a single screening test in the identification of frailty.
We attempted to identify nutritional biomarkers that were independent risk markers of cognitive decline in a population of older Japanese.
We attempted to identify parameters correlated with SHIM score and to determine the factors affecting cardiovascular risk based on hs-CRP levels.
We attempted to mitigate the effect of patient-related factors using a multiple-logistic regression technique and data subsetting.
We attempted to modulate neuroinflammation by subjecting the animals to an anti-inflammatory treatment with pioglitazone ( 5-weeks ' treatment , 5-week wash-out period ) .
We attempted to validate the life table model used to generate estimates for all-cause mortality in developing countries.
We attempt to compare the efficacy of PRF relative to conservative management for chronic hip pain.
We attempt to provide an integrative view of dreaming which embraces the fundamental ambiguity of dreams across the lifespan.
We attribute this to the number of excitatory neurons and the excitatory conductance decreasing with age.
We audio-recorded and transcribed verbatim @number@ semi-structured , qualitative interviews with older partners , their adult children , and grandchildren.
Weaving department included almost @percent@ of workers.
We await the outcome of these agents on macrovascular complications such as stroke.
Web-based approaches have the benefit of being easily and conveniently accessed by individuals worldwide.
Web-based campaigns are efficient in reaching a large number of people but tend to attract a selected and self-selected population.
Web-based campaigns were also described.
Web-based information ( ORadj @number@ @percent@ CI @number@ @number@ ) was less frequently used when the participant was born outside Germany.
Web-based interventions can provide accessible support to family caregivers to offset declines in their health and well-being.
We begin by providing definitions and background about cognitive functioning and how it changes over the life span.
We begin this article with a brief overview of the history of retirement and then note the various definitions used when studying retirement.
We begin with recent findings on intimate dyads , then move to social participation , and finally to elder mistreatment.
We believe economic and other integration efforts can further these aspirations.
We believe it is promising to target SNCA for developing novel therapeutic strategies for parkinsonism.
We believe that by implementing MSNAP it will be possible to improve the quality of UK memory services.
We believe that conditioned medium may be a useful material for anti-aging skin therapy instead of cell therapy.
We believe that continuous monitoring of the DPAA-exposed people may promote the effect of carcinogen and accelerate brain aging.
We believe that developing advanced medicine is an attempt to bring health care reform in line rather than the goal of health care reform.
We believe that it is important to have predetermined best practices for preventing and fixing common symptoms.
We believe that our results may contribute to better understanding of the biological and pharmacological effects of curcumin on the human cardiovascular system.
We believe that our results would be useful for sharing information on the planning and implementation of future university health promotion programs.
We believe that the increased variability might stem from a strategic use of double support to re-stabilize from balance perturbations during gait.
We believe that the reference values provided here will be useful for defining abnormal LV synchronous contraction and relaxation.
We believe that the restriction of cell proliferation in an aging multicellular organism is not a consequence of implementing a special program of aging.
We believe that these findings will be very useful for future genetic studies of AD.
We believe that these preliminary results merit further investigation.
We believe that the success of public health interventions , such as those for tuberculosis , can be translated to HCV infection.
We believe that this discussion will help increase the number of cadaveric kidney transplantations and improve the treatment outcome.
We believe that this protocol can aid researchers in the field to determine altered lipid patterns in neurodegenerative diseases and brain injury.
We believe that TPC is a safe and reliable procedure for the management of intractable pneumothorax secondary to LAM.
We believe that words and concepts have deep implications for how concepts ( such as aging ) are culturally and historically perceived.
We believe this will move DARWIN-T2D to the next generation of real world studies.
We briefly review the life cycles and molecular functions of these ncRNAs.
We brought together the collective expertise of our mouse and human immunology research programs to reverse engineer a clinical observation into a mouse model system.
Websites which purport to provide memory screening are numerous and can influence health behaviours ; however there is currently limited evidence regarding their validity.
We built a functional interaction network linking the proteins differentially expressed between mature and older women.
We built an interaction Network with Cytoscape , this was used to identify pathways , miRNA and drugs associated to ALS.
We built a website to make each process understandable by caregiver advocates.
We built ordinary least square linear regression models to predict the baseline threshold and deterioration rate.
We calculated 2- , 7- , and 14-day moving averages of 24-hour mean and 24-hour variability of temperature.
We calculated adjusted hazard ratios comparing HIV status and controlling for demographics and other established risk factors.
We calculated age-specific incidence rates with the person-year method in 5-year bands.
We calculated amyloid / NFT stage ratios to account for possible changes in AD prevalence / severity over time.
We calculated and compared the effect sizes of age , comorbidity and mental health symptoms using multimediator analysis based on OLS regression.
We calculated concordance correlation coefficients ( CCC ) and created Bland-Altman plots to evaluate the relationship between the two course distances.
We calculated direct cost and indirect cost ( morbidity cost and mortality cost ) , and estimated the COI by summing them up.
We calculated distance between incident and prevalent microbleeds within and between persons and performed lobar segmentation on the magnetic resonance images.
We calculated free androgen index ( FAI ) .
We calculated how aging affects recovery function of SEFs.
We calculated mean cognitive test scores and cut-off scores for cognitive tests published in two or more articles.
We calculated odds ratio ( OR ) with a @number@ % confidence interval ( CI ) .
We calculated Quick EXIT scores from the EXIT.
We calculated sex-specific educational differences in disability-free life expectancy between the ages of @number@ and @number@ years using the Sullivan method.
We calculated summary estimates using random-effects meta-analyses.
We calculated summary risk estimates across cohorts with pooled analysis and random-effects meta-analysis methods.
We calculated the 30-day rAAA-related mortality for all rAAA patients admitted to our hospital.
We calculated the association between the pollutants and impaired glucose metabolism by multiple regression models.
We calculated the correlation coefficient and slope of the relationship between the WIQ and maximal treadmill walking time.
We calculated the cytoplasmic volume of the blastomeres.
We calculated the frequencies of the CoDe codes for the causes of death in each classification category.
We calculated the mean difference between renal function before cinacalcet and at @number@ months on cinacalcet treatment for each study.
We calculated the mean red blood cell ( RBC ) life span within individuals to lie between @number@ and @number@ days.
We calculated the median age of donors and the general population and determined the percentage of each group in age and sex cohorts.
We calculated the odds ratios ( ORs ) for CAD risk and measured serum PUFA composition and lipid peroxide.
We calculated the percentage of patients treated at each type of medical facility with different treatment modalities.
We calculated TH-mediated , non-TH mediated , and total effects of PFASs on neuropsychological test scores.
We calculated time to expected onset as the difference between age at assessment and mean age at onset within the family.
We calculated weighted mean prevalence and applied an epidemiological model linking age with the prevalence of asthma.
We calculated weighted proportions and used chi-square tests for differences across categories by SCD status and receipt of care.
We calculated whole body production ( WBP ) and metabolite to metabolite interconversions.
We calculated z scores for LTL to standardize LTL measurements across the cohorts.
We calibrated it using a nationally representative sample of adults over the age of @number@ in the USA and established diagnostically relevant cutoff points.
We call this signature an epigenetic switch.
We call this structure the septum subcutaneum parotideomassetericum.
We can check the quality of the bronchoscopic procedures retrospectively , which is useful for bronchoscopy staff training.
We can consider NSPCs as endogenous flexible tools to fight against neurodegenerative and neurological disorders and aging.
We can estimate population referral rates and thus enable cost benefit analyses for osteoporosis detection by dentists.
We can evaluate acute and chronic effect of various additives to the dialysis fluid on function and permeability of the peritoneum.
We can find out more effective measurement that resist immunosuppression through research and provide referable science activity form and suggestion of sports nutrition supplements.
We can implement the method using historical data or start from scratch.
We can interactively modify the threshold for highlighting and instantaneously visualize results.
We cannot completely rule out an opposing adverse effect of exposure to progestin injections and / or progestin implants.
We cannot rule out however whether the number of repeats influence the phenotype.
We can only speculate on the reasons , such as differences in the health care , political and social system.
We can state as an example : Abeta passive and active immunization , secretases modulation , Abeta degradation enhancement , or antiaggregation and antifibrillization agents.
We can use this diagnostic under both prospective and retrospective sampling designs , and it may ascertain general forms of misspecification.
We captured psychiatric symptom burden using the Geriatric Depression Scale ( GDS ) and proxy-informed Neuropsychiatric Inventory-Questionnaire ( NPI-Q ) .
We carried out a GWA meta-analysis in @number@ @number@ individuals from East Asia.
We carried out a Sensory Organization Test and Limits of Stability with the Neurocom Smart Balance Master ( ® ) posturography platform.
We carried out a stratified analysis in participants with more pronounced arterial stiffness ( SphygmoCor aPWV > 12 m / s ) .
We carry out a comprehensive assessment of the implications of demographic change for global emissions of carbon dioxide.
We categorized studies based on two related but distinct cognitive domains : ( @number@ ) executive functions or ( @number@ ) dual-task ability.
We categorized the controls into @number@ age groups and analyzed each AUC in the @number@ conditions.
We categorized the human chaperome of @number@ genes into network communities using function , localization , interactome , and expression data sets.
We caution against the overinterpretation of clinical results of genomic testing in the absence of a better understanding of clonal selection and evolution.
We characterized a subset of high affinity tau antibodies , each capable of engaging and neutralizing eTau.
We characterized both the age- and gender-based trends of UBT results , from early childhood through late adulthood.
We characterized leukocyte and T lymphocyte subpopulations by flow cytometry.
We characterized @number@ geriatric conditions encompassing multiple functional domains , its health impact and associated risk factors in HIV-infected and age-matched uninfected controls.
We characterized spinal cord microvascular pathologies and examined their associations with other spinal and brain postmortem indices and parkinsonism in older adults.
We characterized the distribution of a modified HAI ( mHAI ) by sociodemographics in a representative sample of the U.S. population.
We characterized the GM structure by @number@ pyrosequencing of the @date@ region of the 16S rRNA gene.
We characterized these developmental changes on common MRI sequences and identified clinically useful milestones of transition.
We characterized the steady state UPE and performed a skin survey.
We characterized the system rate-limiting biochemical reactions by integrating these experimentally derived data into a mechanistic-computational model.
We characterized this variant using biochemical cell surface expression assays and found that it significantly altered cell surface expression of the TREM2 protein.
We characterized three approved IVIg products : Gammagard® , Privigen® , and Octagam®.
We charted daily variations in intrusive thoughts to gain access to adult age differences in affective reactivity to daily stressors.
We chose not to subcategorize each infertile male by infertile diagnosis because our goal was to understand how semen parameters influenced familial childhood mortality.
We chose the grounded theory approach for our analysis.
We chose the hybrid concept analysis method because its inclusion of old people perspectives enriches the limited health research literature.
We claim that age aspects should more carefully be taken into consideration in translational proof-of-concept studies.
We clarify this pattern and show that it is sufficiently explained by two factors.
We classified eating arrangements as the daily frequency of eating-with-others ( 0-3 ) .
We classified participants as \ "At-Risk \ " and \ "Not-At-Risk \ " for falls using a validated physiological falls-risk assessment.
We classified the secondary medical areas into four groups using component scores.
We close with a call for the use of specialised multi-disciplinary services to improve the overall quality of care.
We close with a discussion of the prospective epigenetic implications of APOE in disease.
We coded mobility and socialization measures from video recordings.
We collected a serum sample from each subject and measured each participant's VEGF level by an enzyme-linked immunosorbent assay ( ELISA ) .
We collected cross-sectional data from the SAGE Well-Being of Older People Study @number@ on @number@ men and women aged @number@ years and above.
We collected data from @number@ participants 13-80 years of age , using an experience sampling method.
We collected data from @number@ patients ( @number@.7±9.4 y.o. ) , none of them were seeking medical care due to sensory or balance decline.
We collected data from seven sMTC patients from the years @number@ to @number@ and analyzed their clinic-pathological features up to @number@
We collected data of self-reported vaccine use from the Korean Community Health Survey.
We collected data on brain structural and ASL perfusion MRI in @number@ healthy children aged 5-18 years.
We collected data through in-depth interviews with participants and conducted a thematic analysis.
We collected data through interviews , clinical examinations , and laboratory tests.
We collected environmental data of daily temperature , available from collaborative public and governmental institutions.
We collected ERPs in young and old participants performing a word-encoding task.
We collected individual participant data on thyroid function and stroke outcome.
We collected > @number@ 3D human facial images and blood profiles well-distributed across ages of @number@ to @number@ years.
We collected @number@ biopsy specimens from @number@ patients , @number@ samples from the right colon and @number@ from the rectum at the follow-up colonoscopy.
We collected patients ' data from the administrative database to compare clinical and medical economic outcomes of elderly patients with hemorrhagic peptic ulcers.
We collected published plasma total IGF-1 data for adults of @number@ mammalian species and analyzed it with respect to body mass.
We collected seventy-eight samples of 24-h urine in preschoolers who were attending daycare centers in the Western Highlands province of Quetzaltenango , Guatemala.
We collected their basic demographic data , administered the Camberwell Assessment Needs Forensic Short Version and carried out in-depth qualitative semi-structured interviews.
We collected umbilical cord blood samples ( N = @number@ ) and isolated genomic DNA from cord blood leukocytes using quantitative polymerase chain reaction.
We combine an individual cell-based model of stem cell populations with a model of epigenetic regulation of transcription.
We combined individuals with incident MCI and dementia to form one group representing those who declined.
We combined multiple perceptual learning approaches that have individually contributed to increasing the speed , magnitude and generality of learning into a perceptual-learning based video-game.
We combined polynomial regression analyses and the minimal clinically important difference to stratify the patients as responders and nonresponders for each intervention approach.
We combined this information with surveys to identify the cause and age of death for individuals in this community who died before this period.
We compare age-related changes of regulatory states in quiescent stem cells occupying a niche with those observed in proliferating cells.
We compared AD , aMCI , and healthy participants on olfactory identification and memory assessed unirhinally.
We compared age-associated differences in global and segmental control during dual-task walking in sub-optimal sensory conditions.
We compared age effects in two different adaptation paradigms that tap into low- and high-level adaptation processes.
We compared baseline brain MRI , neuropsychological tests , and health risk factors.
We compared changes in body mass index ( BMI ) with changes in the prevalence of over-nutrition across the @number@ years.
We compared cognitive performance with CARs using analyses of covariance adjusted for a number of health factors and comorbidities.
We compared CSF levels between patients with and without postoperative delirium and examined the association between CSF cytokine levels and delirium severity.
We compared demographic factors associated with non-participation.
We compared different platelet function assays in patients treated or untreated with aspirin.
We compared doubly labeled water measurements of TEE among @number@ primate species with similar measures for other placental mammals.
We compared each state for the frequencies of @number@ Hz and @number@ Hz between the two groups.
We compared endogenous SirT1 expression in young and old human donors.
We compared estimates across both groups to a matched community-based cohort sampled from the general population.
We compared facility support and related services and resident characteristics by province , owner-operator model , and number of facility units.
We compared four strategies : doing nothing , maternal GBS vaccination , RFB-IAP , and vaccination plus RFB-IAP.
We compared groups for which memory-related stereotype threat ( ST ) was activated or relieved to a control group.
We compared happiness between younger adults ( aged 16-59 ) and those aged 60-69 , 70-79 and 80 + .
We compared hours of care received and unmet activity need among the @number@ white and @number@ black stroke survivors.
We compared immunoreactivity and staining patterns for GVD markers.
We compared impairment thresholds of 1-SD and @number@.5-SD to determine if different cut-offs differentially affect occurrence rates.
We compared LTFU at other age transitions during the adolescent / young adult years.
We compared LV volume obtained using DTI with that obtained using validated segmentations of the LV on T1-weighted data.
We compared manual measurements results to laboratory normal values.
We compared markers of endotheliopathy with physical flow dynamics after traumatic hemorrhagic shock.
We compared measurements to published values for patellofemoral instability.
We compared median nerve normal values between samples of Indian and Dutch populations.
We compared mortality and CVD outcomes in those reclassified to a worse eGFRcys category with those unaffected.
We compared muscle co-contractions of the ankle joint between young and elderly subjects during a functional stability boundary test at different speeds.
We compared naming when exemplars were presented in a semantically homogeneous or in a semantically heterogeneous context.
We compared neuropsychological performance using language and Mini-Mental State Examination ( MMSE ) test scores before and after @number@ and @number@ stimulation sessions.
We compared @number@ geriatric psychiatry outpatients and @number@ psychotropic-naïve family medicine controls aged ≥65.
We compared @number@ premenopausal female corpses to @number@ postmenopausal female corpses and @number@ postmenopausal women undergoing posterior colporrhaphy to @number@ postmenopasusal female corpses.
We compared our experience with those reported in the literature to comprehend the feasibility , outcomes and lessons learned regarding surgical treatment.
We compared our findings with those of age and protein intake.
We compared our main effect findings using SEMs with those obtained using linear mixed models.
We compared outcomes between the two TBI groups using regression models adjusting for demographics , medical comorbidities , and depression.
We compared overall and cardiovascular mortality rates , models adjusted for age , gender , smoking , race , diabetes , and BMI.
We compared patient characteristics between younger and older IMN patients.
We compared patients ⩾65 years old with those < 65 years old.
We compared PBMC proliferation before and after stimulation with ConA.
We compared performance and clinical applicability of BRCAPRO version @number@ vs version @number@ in order to assess diagnostic accuracy of updated version.
We compared performance of the groups on a battery of tests measuring EF and component processes both before and after exposure to emotionally evocative stimuli.
We compared performance on each neuropsychological test between carriers and non-carriers.
We compared prevalence and incidence , as well as mortality , and survival associated with disability over the 20-year period.
We compared prevalence and severity of menopause symptoms using the menopause rating scale ( MRS ) .
We compared quality indicators and outcomes between patients transferred from a peripheral hospital and those directly admitted to the trauma centre.
We compared relationships of memory functions to each other and to other cognitive functions including psychomotor speed and verbal and spatial working memory.
We compared results between examiners and analysts.
We compared retirement planning perceptions of these adults with heterosexual adults and examined the potential role of social support.
We compared retrieval-induced forgetting during a free recall test by using Deese / Roediger-McDermott ( DRM ) lists with an associative structure as the stimulus.
We compared RSV-induced innate cytokine production in blood mononuclear cells from neonates , young children aged 12-59 mo , and healthy adults.
We compared safety and efficacy data across different age groups.
We compared scores on self-management ability and well-being of the IMP and RCT.
We compared sex-related differences in the effect-site concentration ( Ce ) of remifentanil for preventing QTc interval prolongation among elderly patients.
We compared the association of CT and anthropometric measures of obesity with kidney outcomes in the Health Aging and Body Composition Study.
We compared the benefits of repeated testing and repeated study on cued recall of unfamiliar face-name pairs in healthy middle-aged and older adults.
We compared the cardiovascular responses to three different RE protocols performed by @number@ healthy elderly on a leg press machine.
We compared the cases aged @number@ or older that received clipping or coil embolization with the controls that the family selected conservative treatment.
We compared the characteristics of TDS in men with CKD versus renal transplantation ( RT ) with those of age-matched normal controls.
We compared the cognitive health of older adults in New Zealand and the USA , and examined differences in known risk factors.
We compared the effectiveness of home telerehabilitation with conventional rehabilitation following knee replacement surgery ( total knee arthroplasty , TKA ) .
We compared the effects of high- and low-resistance training on muscle volume , muscle strength , and force-velocity characteristics.
We compared the expression of selected cell cycle proteins in prenatal and adult tissue and examined the association of these proteins with β-cell replication.
We compared the extent of resection , treatment type and modality.
We compared the frequency of bleeding complications between patients with prior warfarin use and those without.
We compared the frequency of @number@ risk factors between the subgroups , and used Cox-regression to examine the effect of risk factors on cognitive decline.
We compared the groups and verified if microbleeds were predicted by all other variables.
We compared the groups in the morphological characteristics of their cerebral surfaces while controlling for age and illness duration.
We compared their relationships to each other and to other cognitive functions including attention , psychomotor speed and working memory.
We compared their trajectories with those of @number@ persons without dementia.
We compared the levels of fluorine observed in people between the two studies and found them to be comparable.
We compared the life expectancy at age @number@ of the various artists with the elite and middle class of that time.
We compared the magnitude of this effect in younger and older adults , with and without distractors , in a simple visual-detection task.
We compared the mortality rates between the triple and dual antiplatelet therapy groups.
We compared the performance of different cutpoints of low lean mass and slow gait speed in predicting death.
We compared the performance of @number@ patients with Korsakoff's syndrome and @number@ healthy controls.
We compared the performance of the gene score with the phenotypically derived Framingham Offspring Study T2D risk model and then the two in combination.
We compared the prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage according to these criteria.
We compared the prevalence of falling in the past month between stroke survivors and demographic and comorbidity matched controls using sequential Poisson regression models.
We compared the prevalence rates of sarcopenia determined by the two algorithms.
We compared the radiological changes in the lordotic and segmental angles in different body positions and at different ages.
We compared the rate of potentially preventable hospitalizations among patients who received primary care from NPs versus generalist physicians.
We compared the retinal nerve fiber layer ( RNFL ) thickness from OCT between the three groups.
We compared the risk score to the N-terminal prohormone of B-type natriuretic peptide ( NT-proBNP ) for predicting all-cause mortality and CV mortality.
We compared these CSIs with test point clusters used by the Glaucoma Hemifield Test ( GHT ) .
We compared these estimates to the Canadian Health Measures Survey and previous studies in industrialized and subsistence populations.
We compared these mortality indices between the @number@ Ontario prison cohort and the general population by age group and sex.
We compared the severity of CSVD , the pulsatile index ( PI ) of both middle cerebral arteries ( MCAs ) , and BaPWV.
We compared the use of cognitive and psychiatric medications in FTD and AD and evaluated the relationship between neuropsychiatric symptoms and medication use.
We compared two approaches , Rostock and Forensic , coupled with a Bayesian methodology , to address these issues.
We compared VIS and FIS in elderly subjects and healthy adult subjects.
We compared wave @number@ active stands , dead vs alive in wave @number@
We compared weighted frequencies of transition patterns across years.
We compared WMH volumes between HIV + and HIV- groups in cross-sectional and multiple time-point analyses.
We compared ΔF508 mutant mice with wild-type ( WT ) littermates.
We compare four different NMF algorithms and find that the sparsest decomposition is also the most differentiating between ADHD and healthy patients.
We compare hippocampal volume and shape in population-based incident cases of Alzheimer's disease and vascular dementia ( VaD ) .
We compare response rates and examine time trends in response patterns using adjusted logistic regressions.
We compare the advantages and disadvantages of each method and provide researchers with guidelines for choosing the best method for their particular needs.
We compare the probabilistic distributions of the conventional and prospective measures using examples from China , Germany , Iran , and the United States.
We compare the size distributions of disease and death and see that they have qualitatively different properties.
We compare the validity of prospective versus retrospective measures of health changes by investigating their predictive power for subsequent mortality.
We compare this portrayal with real-world gerontological evidence and age stereotypes and discuss how the portrayal might affect viewers.
We compare trends in activities and disability for Americans ages @number@ to @number@ in recent years , and assess cross-sectional linkages of activities and disability.
We completed a structured process to develop definitions and imaging standards for markers and consequences of SVD.
We completed this trial to determine if smoking cessation decreases the progression of cognitive decline in later life.
We computed a Mediterranean diet score ( MDS ) on the basis of nine a priori defined peculiar characteristics of the Mediterranean dietary pattern.
We computed network-level measures such as density , number of components , and centralization to assess the cohesiveness of the network.
We computed pairwise group differences for key graph metrics , including small-worldness and modularity.
We computed Pearson and Spearman correlation coefficients to examine the correlation between sociodemographic and physical function variables.
We computed perfusion images and ran a voxel-based analysis within all brain structures.
We concentrate on incident dementia risk over @number@ years.
We concentrate on the influence of epigenetics on the age a distribution of genetic mortality m ( a ) .
We conclude by clarifying the distinction between protection and rescue strategies and by highlighting important areas of future research.
We conclude by discussing future directions that may offer opportunities to fully understand nucleation and further AD drug development.
We conclude by discussing possible molecular mechanisms underlying the neuroprotective effects by T-type calcium channel blockers.
We conclude by discussing the opportunities and challenges for future modelling in this field.
We conclude by encouraging social scientists to move beyond the debates of the 1970s and toward a deeper appreciation for modern APC methodologies.
We conclude by highlighting open theoretical questions and considering the practical implications of an increased sense of self-continuity with advancing age.
We conclude by outlining research questions that are ripe for social science inquiry.
We conclude by suggesting a possible guide for future research in this area.
We conclude CTCF plays a central role in mediating the effects of NF-κB activation that result in altered imprinting both in vitro and in vivo.
We concluded that aging images are a promising intervention for reaching young women and increasing their motivation to stop smoking.
We concluded that a short-term Bikram yoga intervention improved glucose tolerance in older obese , but not in young lean adults.
We concluded that a stiffer body combined with heightened visual sensitivity in older women critically interferes with their ability to counteract posturally destabilizing environments.
We concluded that evidence of such an association is weak and vulnerable to the composition of the neighbourhood.
We concluded that in healthy integument , the accumulation of final glycation products increases with age and is amplified by ultraviolet exposure.
We concluded that long-term exercise training from adulthood to old age is clearly associated with a healthy profile of emergent geriatric biomarkers.
We concluded that most of the typical gait features of older age do not result from a slow evolution over the life course.
We concluded that rural hospital work environments may not be optimized to facilitate the delivery of quality geriatric care.
We concluded that serum cystatin C level is independently associated with the long-term progression rate of the cerebral WMH volume.
We concluded that telomere shortening promotes metastatic tumor development in a Terc null mouse model of head and neck cancer.
We concluded that the majority of the old people living in the community present various clinical conditions that prompt disability.
We concluded that the old persons ' falling risk and physical fitness level should be evaluated in some intervals.
We concluded that the porcine model is excellent to test hypotheses related to disc degeneration while permitting time-course study in biologically active systems.
We concluded that the prevalence of hypohydration among elite young athletes is very high , as indicated by the USG and urine color values.
We concluded that these distinguishing features hindered full recognition and acceptance of HIV as an LTC.
We conclude progressive resistance training restores age-related declines in sex steroidogenic enzyme and muscle sex steroid hormone levels in older men.
We conclude that abnormal SPPB score was associated with abnormal pulmonary function.
We conclude that across adulthood , sensory information and knowledge differentially support empathic accuracy.
We conclude that actual learning experiences improve one's self-concept of abilities.
We conclude that acute exercise can have distinct effects on brain activity and mood variables in young individuals when compared with elderly adults.
We conclude that adaptive testing combines brevity with precision , especially in grading the severity of cognitive impairment.
We conclude that AD causes large-scale disconnection that is present before onset of symptoms.
We conclude that AD-related olfactory identification deficits are not directly related to Aβ burden.
We conclude that adult female Black Brant distribute themselves in an ideal free manner , resulting in equal fitness among females using these areas.
We conclude that advanced age does not preclude a beneficial response to NPC transplantation following experimental stroke.
We conclude that affective experiences are not only less variable in the majority of older adults , but also less complex.
We conclude that age and sex do not influence basal muscle protein synthesis.
We conclude that age-associated comorbidity affects physical function in HIV-infected patients , and may modify the effect of aging.
We conclude that age has dissociable effects on configural face-encoding processes , with a relative preservation of vertical compared to horizontal second-order relations processing.
We conclude that age-related changes in color perception can contribute to the differences in Stroop effects observed in aging.
We conclude that age-related differences in basic bottom-up processes may contribute to many purported declines in higher-level functioning in older people.
We conclude that age-related hippocampal deficits in female rats share commonalities between human and rodents.
We conclude that aging may impair the ability to quickly adapt to changing environmental circumstances when they require reformulating current behavioral strategies.
We conclude that alterations in gray matter asymmetry may not be part of the healthy aging process.
We conclude that altered gene-specific DNA methylation is a recurrent and functionally relevant downstream response to trisomy @number@ in human cells.
We conclude that a more responsive WM network contributes to higher WM performance , regardless of adult age.
We conclude that an important cause of age-related impairment in prosodic emotion comprehension exists at the fundamental sensory level of processing.
We conclude that ankle muscle co-contractions in the elderly are not associated with an increase , but a decrease in postural steadiness.
We conclude that both bone accrual and loss are direction-specific in weight-bearing bones but relatively uniform in non-weight-bearing bones.
We conclude that both facilitatory and inhibitory impairments contribute to age-related deficiencies in proactive cognitive control.
We conclude that Caspase-6 activation in mouse CA1 neurons is sufficient to induce neuronal degeneration and age-dependent memory impairment.
We conclude that cataract grade or lens opacity is unlikely to provide a non-invasive measure of the risk of developing Alzheimer dementia.
We conclude that change in environmental dynamics is associated with specific adjustments of control properties of the motor system.
We conclude that chronic or discretionary exposure to IRA could play a role that is more important than expected in premature skin aging.
We conclude that chronic PARP-1 inhibition appears to be beneficial in conditions of chronic oxidative stress but may be detrimental under relatively normal conditions.
We conclude that contextual reminders are not sufficient to trigger memory updating in aged rats or aged humans , unlike in younger individuals.
We conclude that CR fitness is chronically reduced in those with AD.
We conclude that DAP12 , partly through TREM1 / 3 , is involved in renal inflammation during progression of UUO.
We conclude that degraded cognition in older age could explain why adaptation is impaired while aftereffects remain intact.
We conclude that diflunisal affects the cell membrane organization and inhibits prestin-associated charge transfer and electromotility at physiological chloride concentrations.
We conclude that DLK1 ( PREF1 ) is well expressed in human ASC and acts as a negative regulator of adipogenesis.
We conclude that EC is a critical determinant of how multidimensional feature processing is carried out.
We conclude that elevated GIP levels in obesity are likely a consequence of increased endocannabinoid levels.
We conclude that familial longevity is characterized by a high circadian rhythmicity of non-HDL-C in healthy elderly offspring from nonagenarian siblings.
We conclude that faster vagal recovery from cognitive challenge is associated with reduced deficits in EF among older , but not younger individuals.
We conclude that FR combined with Everolimus may be an effective modality to overcome radioresistant tumors via targeting tumor ECs.
We conclude that FreeSurfer constitutes a feasible method to assess differences in hippocampal volume in young adults.
We conclude that frontal-parietal functional reorganizations may reflect compensational mechanisms related to aging , but do not obviate diminished visual-spatial WM performance in older people.
We conclude that higher R2 -determined iron in the basal ganglia correlates with cognitive impairment during brain aging independent of concomitant brain abnormalities.
We conclude that hippocampal shape derived from MRI scans is predictive for dementia before clinical symptoms arise , independent of age and gender.
We conclude that , if asthma involves an increase in ASM velocity , this could be an important factor in the associated AHR.
We conclude that in aging muscle , the circulating factor wnt-3a acts to increase CCN1 expression , prompting muscle senescence by activating cell arrest proteins.
We conclude that increased postprandial lipemia in the elderly involves increased contribution of ingested lipid to the plasma small TRLs.
We conclude that increased rapid-onset cortical plasticity may contribute to largely preserved cognitive and motor function despite extensive ischemic SVD.
We conclude that increasing biological age in community-dwelling adults is associated with gastrointestinal dysbiosis.
We conclude that individual differences in anterior , not posterior , HC volumes predict context memory performance in young adults.
We conclude that induction of p53 does not activate the senescence program in quiescent cells.
We conclude that informal relational pathways hold promise for helping to transform the Canadian long-term care sector.
We conclude that in healthy adults , deterioration of axonal integrity and ensuing breech of connectivity may underpin age-related slowing of information processing.
We conclude that in older persons , besides the previously reported increased antagonist muscle co-activation , the muscle firing sequence is also profoundly altered.
We conclude that in vitro described properties of keratinocytes and fibroblasts in newborns could participate on the almost scar-less wound healing in earliest neonatal period.
We conclude that IVT is safe and at least as beneficial for Chinese young adults with acute ischemic stroke compared with older patients.
We conclude that LA and AG are useful factors for predicting the risk of postoperative complications.
We conclude that LCn-3PUFAs have anabolic properties in healthy young and middle-aged adults.
We conclude that leucine , as a standalone nutritional intervention , is not effective in the prevention of muscle wasting.
We conclude that lifelong caloric interventions fail to prevent or induce loss of age-associated HSC functioning.
We conclude that low SES defined in terms of education but not current socioeconomic circumstances is associated with shortened telomeres.
We conclude that maintenance of normal thyroid function might be important for a preserved immune response in elderly human populations.
We conclude that maintenance of youth-like task-relevant activation patterns is critical for preserving memory functions in later adulthood.
We conclude that MAO increases in those regions of HD brains which are known to undergo neurodegeneration accompanied by glioses.
We conclude that meditation interventions for older adults are feasible , and preliminary evidence suggests that meditation can offset age-related cognitive decline.
We conclude that monoclonal antibody 1H6 is a valuable tool for further studies on the role of G4 DNA in cell and molecular biology.
We conclude that more sensitive techniques are needed to measure tau forms in CSF.
We conclude that multiple genes play important roles in HS-Aging , which is a distinctive neurodegenerative disease of aging.
We conclude that muscle spindles in the human young masseter and biceps precede the extrafusal fiber population in growth and maturation.
We conclude that neuronal histamine production remains largely unaltered in PD despite the abundant LB / LN accumulation in the TMN.
We conclude that neurosyphilis is a relevant differential diagnosis in patients developing severe psychiatric symptoms in old age.
We conclude that NMES enhances low motor excitability in patients with SCA and that the mechanism of the neuromodulation was supra-segmental.
We conclude that normal aging adults lose the compensatory strategy of flexibly controlling multiple joints when stabilizing the COM after receiving a balance perturbation.
We conclude that novel approaches for estimating age , not only morphometric criteria , must be pursued.
We conclude that Nrf1 may not be directly responsible for the loss of Nrf2-dependent inducibility of antioxidant and cytoprotective genes observed in aged animals.
We conclude that @number@ ) RFs appear to originate as small , osmiophilic masses containing both GFAP and alphaB-crystallin deposited on bundles of intermediate filaments.
We conclude that older adults with TBI and nTBI make similar in-patient rehabilitation gains.
We conclude that older fathers endow their offspring with a longer LTL and their daughters with increased susceptibility to breast cancer.
We conclude that organized participation and leadership in this region are urgent tasks of otolaryngologist.
We conclude that OSA can increase brain susceptibility to the effects of aging and other clinical and pathological occurrences.
We conclude that Par4 can bind to the CEBPB promoter and inhibit its transcription.
We conclude that pes cavus is an early and age-dependent manifestation of CMT1A duplication.
We conclude that phosphorylation of LC3 by STK3 / STK4 is an essential step in the autophagy process.
We conclude that piRNAs are abundant in human brains and may represent risk biomarkers of AD.
We conclude that PMA can initiate a senescent program by either inducing arrest or fostering geroconversion or both.
We conclude that poor mobility judgments during a dual-task leads to unsafe mobility for those at-risk for falls.
We conclude that prevalence of pre-frail and frail status in Peruvian Navy Veterans and family members is high.
We conclude that QSM contrast is the preferred choice for the visualization of the STN in persons with PD as well as in aging HC.
We conclude that rats constitute a good model for toxicological investigations during embryonic development , youth and adulthood.
We conclude that religious attendance may promote telomere length indirectly by reducing symptoms of depression and the risk of smoking.
We conclude that resveratrol and its derivatives may act as a therapeutic agents in respiratory diseases and pertinent clinical trials should be performed.
We conclude that SDBOLD is a promising correlate of functional brain health in aging.
We conclude that selection for ( or enforcement of ) lifetime monogamy will select for earlier reproductive investment and against increased lifespan in men.
We conclude that small males experience more rapid seminal depletion than large males , and discuss the role of semen depletion in the mated female.
We conclude that social gradients for frailty are present in older adults , although a causal mechanism is not yet clear.
We conclude that sunitinib might ameliorate Tat-mediated autophagy alterations and may decrease neurodegeneration in aging patients with HAND.
We conclude that sustained experiential demands on spatial ability protect hippocampal integrity against age-related decline.
We conclude that systemically delivered and peripherally produced sex steroids have distinct roles in the regulation of neuromuscular characteristics during aging.
We conclude that TBSS is a promising method in examining the degeneration of neurofiber tracts in MCI and AD patients.
We conclude that the AASI is an independent risk factor for accelerated age-related GFR decline in the general middle-aged population.
We conclude that the body image experience of Western seniors has both specificities and similarities with the one of younger populations.
We conclude that the causation of the empirically observed association of life expectancy and sociality may be more complex than previously realized.
We conclude that the current data suggest telomeres should not be used for age estimation.
We conclude that the DLS approach for accelerometer data improves detailed EE prediction in youth.
We conclude that the Drosophila knock-in model captures important aspects of human SOD1-based ALS and provides a powerful and useful tool for further genetic studies.
We conclude that the elderly population in Portugal is essentially free of MRSA.
We conclude that the hippocampus is implicated in vivid re-experiencing of a familiar route , but not with map-like knowledge of a large-scale environment.
We conclude that the hypocretin system is affected in advanced AD.
We conclude that the imputation of low frequency and rare variants improves with larger reference panels and higher density of genome-wide genotyping arrays.
We conclude that the MAI may serve as a valuable tool for measuring potentially inappropriate prescribing in older adults.
We conclude that the mechanism behind aging-induced sarcopenia is NFκB independent and differs from muscle wasting due to pathologic conditions.
We conclude that the mnemonic benefits of referencing the self extend to specific memory for visual and verbal information across the lifespan.
We conclude that the modified 1-10 RPE scale did not show concurrent validity to HR , with large between-individual variability.
We conclude that the policy debate on active aging may benefit some older German adults but is of little consequence for most of them.
We conclude that the previously reported spatial reference memory deficits of UBB ( @number@ ) transgenic mice persist during aging.
We conclude that the published literature on HS-Aging provides strong evidence of an important and under-appreciated brain disease of aging.
We conclude that the rate of senescence is better described by the derivative function of the Gompertz equation.
We conclude that there is inconsistency in the literature regarding vitamin B12 cut-offs.
We conclude that there is no biological justification for an age-discriminate policy for MM therapy.
We conclude that the role of developmentally programmed senescence is to promote tissue remodeling and propose that this is the evolutionary origin of damage-induced senescence.
We conclude that the rTL in peripheral leukocytes is not strongly correlated with the rTL in different organs.
We conclude that these genetically based cortical phenotypes may be more appropriate for genetic studies than traditional ROIs based on structure or function.
We conclude that the universal approach adopted contains a number of risks and uncertainties.
We conclude that the wellbeing of elderly people is an important objective for both economic and health policy.
We conclude that this study confirms the roles of levodopa usage and cumulative levodopa exposure in the neuropathy of PD.
We conclude that tIFR might not be a biologically relevant measure of the inflammatory impact of the diet.
We conclude that TREM2 is required for promoting microglial expansion during aging and microglial response to insults of the white matter.
We conclude that trisomy @number@ affects cortical structures more than central gray matter emphasizing the differential impairment of brain development.
We conclude that TRPV1 channels are involved in the regulation of both general locomotor activity and body mass in an age-dependent manner.
We conclude that tVNS is a promising neuromodulatory technique to improve associative memory performance in older individuals , even after a single session.
We conclude that type II muscle fiber atrophy with aging is accompanied by a specific decline in type II muscle fiber satellite cell content.
We conclude that upholding these mechanisms may help to optimise the efficiency and productivity of assistant and professionally qualified staff in CBRS.
We conclude that variants of genetic polymorphisms act in synergy with long-term blood glucose control in shaping patterns of cognitive aging.
We conclude that variations in the relative size of the femoral head and neck are important determinants of incident hip fracture.
We conclude that VGF contributes to survival and function of peripheral T cells.
We conclude that visual motion processing is impaired by distinct mechanisms in aging and the transition to AD , implying distinct neural mechanisms of impairment.
We conclude that vitamin D deficiency is a potential risk factor for obesity and development of insulin resistance leading to diabetes type @number@
We conclude that WISW is related to central autonomic function.
We conclude that within-person variability may increase with age , but the degree depends on performance level and the modality investigated.
We conclude that , yet related , they represent two different clinical conditions.
We conclude that yoga is an effective complementary health approach for improving quality of life in menopausal women.
We conclude that β-blockers in general do not convey an increased risk of depression.
We conclude the Companion can help manage NPS and offer caregiver respite at home.
We conclude with a brief discussion of the tradeoffs involved in considering a potential removal of OAS eligibility barriers for immigrants in Canada.
We conclude with a broad set of goals to guide future management driven by a multidiscipline approach.
We conclude with a discussion of directions for future research using dyadic interviews.
We conclude with a discussion of future directions for this exciting and important field of biomaterials research.
We conclude with a discussion of implications and future directions.
We conclude with a discussion of intervention strategies for SCD , ethical considerations , and future research priorities.
We conclude with a discussion of the critical questions that can be addressed with these new methods.
We conclude with implications for the health care system and areas of future research.
We conclude with perspectives for future research.
We conclude with policy and practice implications of these three main findings.
We conclude with recommendations for clinicians not expert in the specialty of cardiology to deal with the many questions raised in this review.
We conclude with some speculation as to future trends in this field.
We conclude with suggestions for novel mechanism-based therapeutics based on these mediators.
We conclude with the emerging evidence that H3.3 is required for proper neuronal function and brain plasticity.
We condense the network , highlighting those links across which the largest changes can be observed.
We conducted a bibliographic search through Pubmed.
We conducted a case-control study to investigate this association in a Chinese population and performed a meta-analysis in different populations to clarify this association.
We conducted a community-based cross sectional study among persons aged > or = @number@ years from Delhi during 2009-2010.
We conducted a community-based pilot dementia training intervention designed to both improve clinical competency and increase utilization of local dementia care services.
We conducted a comprehensive search using PubMed and Google Scholar to identify US-based studies published prior to @date@ , @number@
We conducted a cross-sectional study and evaluated the levels of adiponectin and leptin in relation to coffee consumption.
We conducted a cross-sectional study of self-reported sleep characteristics , chronotype and winter depression in northern European Russia.
We conducted a cross-sectional study of subjects with DLB ( N = @number@ ) and similarly aged control participants ( N = @number@ ) .
We conducted a discrete time survival analysis adjusting for personal characteristics.
We conducted a large-scale migrant cohort study to assess origin and migrant generation as predictors of NPC , controlling for possible confounders.
We conducted a large survey of older people's knowledge of STIs and safer sexual practices.
We conducted a large , two-stage meta-analysis of genome-wide association studies ( GWAS ) in individuals of European ancestry.
We conducted a latent class analysis based on the Internet activities that panel members reported to spend time on.
We conducted a literature search in the PSYCinfo , MEDLINE , and Google Scholar databases for @number@ to @number@
We conducted a longitudinal cohort using a single field protocol and comparable laboratory procedures to examine intestinal permeability in multiple , geographically diverse pediatric populations.
We conducted a meta-analysis investigating if hypovitaminosis D is associated with diabetes in prospective studies among older participants.
We conducted a meta-analysis of genome-wide association data with @number@ individuals and identified eight independent common SNPs associated with serum DHEAS concentrations.
We conducted a meta-analysis of genome-wide association studies to identify novel correlates of circulating levels of tPA.
We conducted a metaanalysis to analyze the serum Mn levels in patients with AD and MCI.
We conducted a mixed-methods study the focus of this article to understand how workers in long-term care facilities experienced working conditions.
We conducted a multicenter single masked randomized controlled trial that enrolled participants in @number@ and @number@ and followed them for an average of @number@ years.
We conducted a multi-stakeholder consultation to identify current and emerging issues in HIV , disability and rehabilitation.
We conducted analyses on a community-based , longitudinal cohort of women enrolled in the Study of Women's Health Across the Nation.
We conducted analysis of two proposed methods to quantify biological aging using data from a recently concluded trial of an established geroprotector , caloric restriction.
We conducted an association analysis on @number@ FTD patients , belonging to @number@ Italian Centers , and for whom AAO was available.
We conducted a national epidemiological survey , involving @number@ physiatrists.
We conducted an electronic search until @date@ on many electronic databases including online registries of ongoing trials.
We conducted a nested cohort study in a community-based aging study ( the Einstein Aging Study ) .
We conducted an experiment to evaluate the ability of @number@ younger and older adults to visually perceive distances in an outdoor setting.
We conducted an individual-based pooled analysis of @number@ twin cohorts including @number@ complete twin pairs born 1886-1994.
We conducted an integrative miRNA-mRNA coexpression analysis and examined the enrichment of biologic pathways for the top miRNAs associated with grip strength.
We conducted an observational study in Danish national registries tracking prescriptions for osteoporosis drugs , comorbid conditions , and deaths.
We conducted a population-based cross-sectional study to identify the prevalence of aging male's symptoms ( AMS ) and factors associated to this condition.
We conducted a population-based study in a rural island town in western Japan , Ama-cho.
We conducted a postal survey to estimate the frequency with which Canadians communicate their preferences about health care and research should they become incapacitated.
We conducted a pre-test and post-test assessment using a visual analogue scale , WOMAC questionnaire and SF-36 as measuring instruments.
We conducted a principal component analysis to create the SASP index based on individual weights of each of protein.
We conducted a prospective study to assess the utility of the CURB65 score in acute COPD exacerbations.
We conducted a prospective study to investigate the influence of AT1R A1166C gene polymorphism on the quantitative changes of renal function.
We conducted a PubMed database search according to the preferred reporting items for systematic reviews and meta-analysis ( PRISMA ) guidelines for systematic reviews.
We conducted a qualitative exploratory study using an embedded case study design.
We conducted a qualitative interview study with people of different professions working with lonely elderly people.
We conducted a qualitative study on retirement preparedness among middle-aged and older low-income Hispanics in Los Angeles.
We conducted a randomized crossover trial with noninstitutionalized adults , who were aged ≥60 years and recruited from a local community center.
We conducted a randomized , double-blind , parallel placebo-controlled trial at an outpatient academic research center.
We conducted a retrospective review of @number@ patients between @number@ and @number@
We conducted a retrospective review of the California Cancer Registry to examine treatment patterns and survival by age.
We conducted a study in @number@ subjects tested in our Sleep Laboratory , to assess regional CBF and cognitive function in OSAS.
We conducted a study to compare treatment decision-making by experienced shoulder and trauma fellowship trained surgeons.
We conducted a study to investigate whether physical activity and appetite status were related to UFOV test performance in healthy older adults.
We conducted a survey to determine the level of interest of adult civilian dependents of ADMP in participating in a group weight control program.
We conducted a systematic review and exploratory meta-analysis comparing bone health outcomes in patients with MGUS.
We conducted a systematic review and meta-analysis of the association between activity restriction and depression in medical patients and their caregivers.
We conducted a systematic review and meta-analysis summarizing the evidence of low BMD and fractures as risk factors for future CVD.
We conducted a systematic review and meta-analysis to describe the association between low 25 ( OH ) D level and frailty.
We conducted a systematic review and meta-analysis to determine if stroke risk is increased following HZ infection.
We conducted a systematic review and meta-analysis to investigate the associations between depression and frailty.
We conducted a systematic review of studies that investigated the association between stress and telomere length in children from @number@ to @number@ years of age.
We conducted a systematic review of these studies.
We conducted a systematic review to assess the state of the evidence regarding the relationship between these two prominent concepts in the geriatric literature.
We conducted a systematic review to examine psychosocial factors that impact how OWLH live , cope , and age with HIV.
We conducted a systematic review to investigate potential interactions between OS and frailty.
We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults.
We conducted a text analysis ( Trend Search-Keyword Associator @number@ ) and extracted the keywords from their responses.
We conducted combined and separate analyses for all ethnic groups studied in the literature ( Caucasian and Asian ) .
We conducted Cox proportional hazard models to evaluate the association between literacy and incidence of likely dementia.
We conducted descriptive statistical analyses on the review processes and resources required.
We conducted in-depth interviews with @number@ participants sampled from the Irish ALS population-based register.
We conducted individual interviews in participants ' homes from @number@ until @number@
We conducted model calculations to estimate prevalences among gFOBT negative individuals.
We conducted multinomial logistic regression to demonstrate the relationship between LOS and severity of PVWHMs , DWHMs , and Overall WMHs , respectively.
We conducted multiplex genetic testing of @number@ cancer susceptibility genes using the peripheral blood DNA of the mother and all five daughters.
We conducted new analyses to further address this controversy.
We conducted @number@ focus groups of licensed and unlicensed nursing staff , medical care providers , and administrators.
We conducted principal component analysis on each diffusion measure , using data from eight individual tracts.
We conducted PSM to reduce the bias due to confounding variables related to survival in patients with AD.
We conducted regression analyses for the seven falls-related categories ( defined above ) .
We conducted regression analyses with bilateral hippocampal volumes as predictors and serial position indices as outcomes.
We conducted secondary analysis on nine data sets.
We conducted semidirective interviews , and a general inductive approach was chosen to capture the representations of the couples.
We conducted semi-structured interviews to explore how participants felt about the benefits and barriers of receiving life review in a group.
We conducted semistructured interviews with @number@ community and academic investigators working on @number@ community-engaged studies.
We conducted surveys of community residents both before ( in @number@ ) and after ( in @number@ ) the opening of the salons.
We conducted survival analysis to compare persistence and Poisson regression to estimate switching rates.
We conducted this prospective nationwide population-based cohort study to clarify this issue.
We conducted this study on a sample of @number@ elderly in @number@ rural districts of Phranakornsiayutthaya province in Thailand.
We conducted three focus groups with @number@ community-dwelling pairs ( a person with dementia and their family caregiver ) .
We confirmed a negative correlation of mtDNA content in blood with age and a higher content in females.
We confirmed a recessive effect of the APOA2 polymorphism and replicated the APOA2-saturated fat interaction on body weight.
We confirmed a seven-factor order model that supports the construct validity of the questionnaire.
We confirmed a shift with aging from with-the-rule to against-the-rule astigmatism to refractive and corneal astigmatism.
We confirmed gene expression of IL16 , STARD5 , and ME3 in multiple lung tissues.
We confirmed it in MCF7 , MDA-MB-436 and two human primary breast cancer cells by showing reduced thiamine levels upon a knock-down of miR-155.
We confirmed microarray gene expression changes by the quantitative polymerase chain reaction experiment.
We confirmed that aged mice have a significant decrease in the frequency of mature NK cells in all lymphoid organs.
We confirmed that an age-associated site in the promoter of the gene Co-morbidities increase markedly with aging , and they often negatively affect its prognosis.
We confirmed that autophagy-associated genes are significantly often up-regulated and co-expressed during aging of P. anserina.
We confirmed that expression of VASH2 mRNA in the tumor was downregulated by siVASH2 treatment.
We confirmed that senescent astrocytes express a characteristic of SASP in vitro by human cytokine antibody array.
We confirmed that susceptibility to fibrosis development increased with age and showed that aging did not affect fibrosis resolution capacity.
We confirmed that tau protein deposition in the posterior pituitary appears histologically as either a ' thread-like ' or ' dot ' form.
We confirmed that the new system was able to recognize foods , drinks and utensils by experiments.
We confirmed that zinc-induced A20 contributes to downregulation of TNF-α and IL-1β by antisense and short interfering RNA A20 studies.
We confirmed the involvement of this pathway in a mouse xenograft model of human NSCLC.
We confirmed these findings in other leukemic cells ( THP-1 , K562 cells ) .
We confirmed these findings with transforming growth factor ( TGF ) -β.
We confirmed , using electron spin resonance , that P-NCP directly inhibited HO ( • ) and ( @number@ ) O ( @number@ ) .
We confirm previous findings that heroin addiction associates with tau hyperphosphorylation in predilection brain areas for aging and Alzheimer disease.
We consecutively enrolled patients with aspiration pneumonia.
We consider accounts of observation inflation based on source monitoring , familiarity misattribution , and motor simulation.
We consider aggregate profiling as an important experimental approach to determine if nuclear amyloid has toxic or protective roles in various disease processes.
We considered a bimanual task in which people chose how much force to produce with each arm so that the sum would equal a target.
We considered downward ( from parent to child ) and upward ( from child to parent ) directions in support exchanges.
We considered environmental and nutritional factors relating to longevity in Chinese cities.
We considered how local variations and local control shape the experience of aging in Sweden and organized the paper into @number@ sections.
We considered randomized controlled trials , non-randomized trials , controlled before-after studies and prospective cohort studies for inclusion and selected studies according to predefined criteria.
We considered this mass caused hypothalamic hypopituitarism.
We considered two groups of home care recipients : elderly individuals and intellectually disabled individuals.
We consider geodesic regression with parametric time-warps.
We consider how changes in both electrical properties and intracellular Ca ( 2 + ) handling may interact to modulate cardiomyocyte contraction.
We consider in particular factors that might result in a greater frailty burden in women , focusing on frailty being measured by a Frailty Index.
We consider our findings in relation to theorizing about ageism , age relations , the Third and Fourth Ages , and idealized aging masculinity.
We consider that detailed characterization of the two types of cellular senescence can be useful in in vitro studies of potential anti-aging factors.
We consider that our study provides new anatomical clues to better understand the cognitive mechanisms underlying the logopenic syndrome.
We consider that these genes merit further attention in future studies as potential candidate genes involved in both idiopathic and LRRK2-G2019S-associated forms of PD.
We consider the evidence in light of neurocognitive frameworks that acknowledge the sometimes complex interactions between age-related declines and compensation.
We consider the implications of this for our scientific and cultural understanding of aging.
We consider the implications of this work for health care policy suggestions and for future research.
We consider the phenotypic and genetic interrelationships between epigenetic age acceleration and white matter integrity in humans.
We consider the problem of monitoring and comparing medical outcomes , such as surgical performance , over time.
We consider the regression or retrogenesis hypothesis , which argues that order of acquisition in development is reversed in neurodegeneration or pathology.
We consider the relation of SCD to important variables and outcomes ( e.g. , AD biomarkers , clinical progression ) .
We consider the relationship between the factors responsible for the general biology of aging and those that specifically influence the aging of the reproductive system.
We consider these @number@ proteins as directly interacting with WRN.
We constructed a MDS disease gene network which suggests the network basis of the heterogeneity of MDSs.
We constructed a vector that drives transcription of the destabilized luciferase in eukaryotic cells under the control of the human PERIOD @number@ gene promoter.
We constructed Cox regression models , adjusted for age , sex , education , and functional status.
We constructed Kaplan-Meier survival curves for all participants , and for four subgroups defined by dietary vitamin C intake and level of smoking.
We constructed linear mixed models to determine whether baseline predictor variables were related to baseline well-being and / or changes in well-being over time.
We constructed multiple mouse models for Poln disruption and detected no anatomic abnormalities , alterations in lifespan , or changed causes of mortality.
We constructed our task by taking factors into account that were known to complicate the measurement of significant and valid priming effects.
We constructed structural brain networks composed of @number@ regions in young , middle , and old age groups.
We constructed two models and tested fitness of the models to the data using a structural equation modeling ( SEM ) .
We contend , however , that population aging is considered as a parameter rather than an independent variable to explain rising health care expenditures.
We contend that decreased Klotho expression is the earliest biomarker of CKD and the initiator of CKD-MBD pathophysiology.
We contrast annual declines in IADL independence for older individuals who remain stroke free to those for individuals who experienced stroke.
We contrasted mortality patterns among people with versus without dementia using Cox proportional hazards models.
We controlled for age , socioeconomic status , violence history , and substance use.
We controlled for individual characteristics and baseline measures of the outcomes.
We controlled for the average objective cognitive abilities of the older population in a subsample of @number@ countries.
We controlled for the variables demographics , physical and mental health , economic satisfaction , and lifestyle.
We convened a conference of @number@ stakeholders in @date@ , and herein present their recommendations.
We converted all probabilities into absolute risks for ease of understanding.
We convincingly demonstrate that the lack of genetic effects on an aging-related trait can be because of trade-offs in the gene action.
We correlated morphologic data with findings from quantitative sensory testing , sudomotor output , sympathetic skin response , and cardiovascular reflexes.
We correlated motor performance of the task with high difficulty and comparable performance with fMRI-activation.
We correlated the changes in expression of these markers with Lee's pathologic grades and the Oxford classification.
We correlated the presence and grade of acute inflammation ( AI ) or chronic inflammation ( CI ) and BPH.
We could not define an acceptable phase angle cutoff for individual prediction of mortality ( LK ) , based on sensibility and specificity values.
We counted repeated / multiple transitions that involved movement into hospital and SNF settings and compared them by demographic characteristics.
We counted the distribution of mutations to CDR in @number@ different human datasets.
We coupled the FEM to a circuit model to capture hemodynamic interactions between the atrium , pulmonary circulation , and left ventricle.
We coupled training with parietal , motor , or sham transcranial random noise stimulation , known for modulating neural activity.
We cover different parts of the nervous system , including the brain , the retina , the cochlea , and the neuromuscular junction.
We cover studies that employ the three primary methods to analyze functional connectivity seed-based , ICA ( independent components analysis ) , and graph theory.
We created 6-month intervals including patients with at least one visit in the past @number@ years.
We created a 5-year prospective cohort study of community-dwelling older Japanese adults.
We created a Cultural Assimilation Scale ( CAS ) using @number@ questions assessing the degree of Japanese identity and lifestyle compared to a Western one.
We created a data display that could be readily automated.
We created and validated a simple instrument for frailty screening in Europeans aged ≥50.
We created a new model of population flow in and out of correctional facilities to estimate the number of persons released in @number@ and @number@
We created a PLO score from the answers to these questions , where @number@ represented the best PLO and @number@ the poorest.
We created a regression model including all five factors and important covariates.
We created a score chart for each sex based on the final model.
We created lists of questionnaire items containing problematic items plus items randomly selected from the pool of remaining items.
We created PhiC31-based transgenic lines for human Hsp27 , Hsp40 , Hsp60 and Hsp70 and compared their activities in parallel against extracellular Aβ42.
We created specific criteria to appropriately classify the quality level of each publication.
We critically evaluate reports of the accumulation of neuronal MVBs based on evidence of stress-induced MVB formation.
We cross-tabulated all active diagnoses with treatments recommended by guidelines for each diagnosis.
We currently have a worldwide aging population.
We currently present and discuss novel bioanalytical strategies developed for the determination of various modified nucleotides in epigenetic studies.
We currently tested whether Berberine can affect premature , stress-induced cellular senescence caused by mitoxantrone.
We data-mined the microblogging platform Twitter for content containing dementia-related keywords for a period of @number@ hours and retrieved over @number@ tweets.
Weddellite was found in @percent@ , with an equal distribution between types IIa and IIb.
We defined age @number@ as boundary line of the elderly patients in lung cancer.
We defined a robust FRDA cardiac-specific electrophysiological profile in patient-derived iPSCs which could be used for high throughput compound screening.
We defined ART initiation as the first pharmacy fill date of a qualifying ART regimen of ≥3 drugs from ≥2 classes.
We defined disability as difficulty with activities of daily living.
We defined genes that are essential for this multigenerational effect.
We defined high-risk ( shorter ) telomere length as ≤25th percentile , and low-risk ( longer ) telomere length as ≥75 percentile.
We defined LOS as the total sum of days from @date@ to @date@ .
We defined malnutrition according to mini nutritional assessment ( MNA ) scale.
We defined MPS based on the presence of any one of bradykinesia , rigidity , or rest tremor.
We defined prevalent CAC using an Agatston score of 100 + and fitted generalized estimating equations to calculate prevalence odds ratios of CAC.
We defined the frontopolar region as the region of interest for analysis , and calculated the Z-score to compare the data between groups.
We define leukocyte telomere length of @number@ kb as the ' telomeric brink' , which denotes a high risk of imminent death.
We define muscular dysfunction as an abnormal result in gait speed and / or handgrip strength tasks.
We define resilience as ' the process of negotiating , managing and adapting to significant sources of stress or trauma'.
We demonstrate a developmental isoform switch of COX6A and COX7A subunits in human and mouse skeletal muscle.
We demonstrated a requirement of nuclear p53 S-nitrosylation in inducing a nitric oxide / PGC-1α-mediated antioxidant pathway in skeletal muscle.
We demonstrated a robust upregulation of AQP4 expression in areas of plaques.
We demonstrated association of rs8887 with anthropometrics.
We demonstrated substantial dermal matrix remodeling , including a degree of collagen production that compares favorably with some more invasive interventions.
We demonstrated successful humanization of germ-free mice by transplanting fecal samples from breast cancer patients before and after chemotherapy.
We demonstrated that AF is associated with Pitx2 promoter hypermethylation both in humans and arrhythmic aging spontaneously hypertensive rats.
We demonstrated that dabigatran-associated GI hemorrhage was significantly increased in patients over the age of @number@ years.
We demonstrated that Foxo1 and Foxo3a were both up-regulated during murine skin wound healing.
We demonstrated that FOXP1 has a repressive effect on AR-induced transcriptional activity or histone modification in enhancer regions.
We demonstrated that genetic variation among mosquitoes contributes significantly to transmission potential and length of EIP.
We demonstrated that KLRG1 was overexpressed on CD4 ( + ) T cells from HCV-infected , HBV vaccine nonresponders compared with HBV vaccine responders.
We demonstrated that mean length and diameter of trigeminal nerve root did not change with age.
We demonstrated that miR-125b was downregulated in both age-related cataract tissue and lens epithelial cell apoptosis induced by UV irradiation.
We demonstrated that short-term and prolonged caloric restriction confers cardioprotection against ischemia / reperfusion injury in young and aged rodents.
We demonstrated that SIPI not only searches for more meaningful interaction patterns but can also overcome the unstable nature of interaction patterns.
We demonstrated that telomeric TTAGGG repeats were more prone to oxidative base damage and repaired less efficiently than non-telomeric TG repeats in vivo.
We demonstrated that the accumulation of uric acid considerably increases the free radical-scavenging activity and resistance against ultraviolet-induced oxidative stress in laboratory-maintained termites.
We demonstrated that topical application of recombinant MMP-9 resulted in a time- and dose-dependent cerebral hemorrhage.
We demonstrated that triolein ( TG ) reduced basal and UV-induced MMP-1 mRNA expression.
We demonstrated that tumor growth rate was higher and survival was lower in old versus young mice ( p < 0.05 ) .
We demonstrated the novel finding that resveratrol promoted VSMC differentiation as measured by contractile protein expression , contractile morphology and contraction in collagen gels.
We demonstrated the presence of exosome-associated Aβ in the cerebrospinal fluid ( CSF ) of cynomolgus monkeys and APP transgenic mice.
We demonstrated the volume fraction of total ventricle to total brain in normal subjects.
We demonstrate for the first time a decrease in membrane-associated Rho proteins in aged brain in association with down-regulation of GGTase-Iβ.
We demonstrate for the first time that excessive daytime sleepiness is greater in ET-MCI than ET-NC.
We demonstrate here that either increase or reduction of expression of either factor results in cellular senescence.
We demonstrate here that the stress-mediated proteasomal activation in the nucleus declines during replicative senescence of human fibroblasts.
We demonstrate here that vps35 genetically interacts with parkin but interestingly not with pink1.
We demonstrate here that Wnt16-deficient mice develop spontaneous fractures as a result of low cortical thickness and high cortical porosity.
We demonstrate its utility in breast and prostate cancer cells.
We demonstrate overexpression of two out of five SPP1 isoforms in glioblastoma ( GBM ) and differential isoform expression in glioma cell lines.
We demonstrate production of a population of putative calretinin-positive bipolar interneurons that express markers consistent with caudal ganglionic eminence identities.
We demonstrate SIRT4-mediated regulation of DLAT lipoyl levels and PDH activity in cells and in vivo , in mouse liver.
We demonstrate that Abhd11os levels are markedly reduced in different mouse models of HD.
We demonstrate that biguanides inhibit growth by inhibiting mitochondrial respiratory capacity , which restrains transit of the RagA-RagC GTPase heterodimer through the NPC.
We demonstrate that both Hba and Hbb are co-localised with the mitochondrion in mammalian brain.
We demonstrate that both latitude of residence and location within the time zone are significant predictors of SADW in young inhabitants of the North.
We demonstrate that by augmenting geodesic regression with parametric time-warp functions , we can achieve comparable flexibility to more complex models while retaining model simplicity.
We demonstrate that CRTC-1 is a direct AMPK target , and interacts with the CREB homologue-1 ( CRH-1 ) transcription factor in vivo.
We demonstrate that DIRAS3 knock-down ( KD ) in ASCs induces activation of Akt-mTOR signaling and proliferation arrest.
We demonstrate that for each of these methods , the addition of the proposed dynamic features results in statistically significant improvement.
We demonstrate that Gcp binds to glycated proteins , including pyruvate dehydrogenase , previously shown to be a glycation-prone enzyme.
We demonstrate that IKKβ itself undergoes K63-linked ubiquitination.
We demonstrate that in senescent human fibroblasts , CHIP is up-regulated concomitant with a significant down-regulation of p53.
We demonstrate that introduction of equivalent stop codons in the full-length human L1 sequence leads to the expression of truncated ORF1 proteins.
We demonstrate that IRS4 overexpression in lung cancer is associated with recurrent deletions in cis , and we present evidence supporting a tumor-promoting role.
We demonstrate that lifelong practice managing two languages orchestrates global changes to both the structure and function of the brain.
We demonstrate that LKB1 and its downstream kinase NUAK1 bind to CDKN1A.
We demonstrate that M2 products decrease interneuronal transfer of oAβ , while recombinant interleukin ( IL ) -4 , IL-10 , and IL-13 increase transfer.
We demonstrate that metformin inhibits the increase in angiogenesis brought about by platelets in a mechanism that did not alter endothelial cell migration.
We demonstrate that most of these age-associated methylation changes are reversed in induced pluripotent stem cells ( iPSCs ) .
We demonstrate that MTO1 mediates tRNA modification and controls mitochondrial translation rate in a highly tissue-specific manner associated with tissue-specific OXPHOS defects.
We demonstrate that NOTCH1 is a target of ADAMTS1 metalloproteinase activity , which reduces Notch signaling , leading to increased satellite cell activation.
We demonstrate that older A1-carriers have worse memory performance , specifically during LTM updating , compared to noncarriers.
We demonstrate that our model yields results which match actual demographic data in the human population.
We demonstrate that particularly the spliced XBP-1 variant dose dependently regulates ADAM10 expression , which can be synergistically enhanced by @number@ nM insulin.
We demonstrate that practice-induced improvements in movement control are associated with changes in activity of multiple motor units.
We demonstrate that pRCC is a heterogeneous group of tumors with distinct evolution.
We demonstrate that REGγ-proteasome is essential for oxidative stress-induced rapid degradation of p21 and HCV proteins.
We demonstrate that SCAI is a mediator of 53BP1-dependent repair of DSBs , facilitating ATM kinase signalling at DSBs in repressive chromatin environments.
We demonstrate that Scrib overexpression suppresses the growth of HCC cells in vitro , and Scrib deficiency enhances liver tumor growth in vivo.
We demonstrate that such an understanding is especially important under disease or resting conditions.
We demonstrate that the activation of mTORC1 signaling ( and subsequently enhanced translation initiation ) is required for the contraction-induced increase in MPS.
We demonstrate that the depletion of nesprin-2 reduces both the amount of active β-catenin inside the nucleus and T-cell factor / lymphoid-enhancing factor-dependent transcription.
We demonstrate that the estimators identify a causal contrast that is a function of principal strata effects under a set of assumptions.
We demonstrate that the expression levels and length of truncated ORF1 proteins influence their ability to suppress L1 retrotransposition.
We demonstrate that the increase in survival rate correlates with a dramatic impairment of the autophagic flux at the autolysosomal maturation step.
We demonstrate that the inflammatory activation of microglia serves as a key node for progressive neurodegeneration.
We demonstrate that the M2H system successfully detects human and mouse ORF1p self-interactions in transiently transfected mammalian cells.
We demonstrate that the membrane-bound ICAM-1 isoform is necessary and sufficient to promote inflammation-dependent extracellular matrix contraction , which favors cancer cell invasion.
We demonstrate that the total deletion load increases with age , while the total number and diversity of unique deletions remain constant.
We demonstrate that this also applies to rare , apparently unambiguous truncating mutations of an established disease gene.
We demonstrate that treatment of cervical cancer cells with a RhoGDIα-derived K52-trifluoroacetylated , substrate-derived peptidic sirtuin inhibitor severely impairs cell proliferation.
We demonstrate the ability of NNMF to produce sparse parts-based representations of the data at various resolutions.
We demonstrate the feasibility of continuous long-term motor activity recordings to study age-related variations of the rest-activity cycle.
We demonstrate the potential of our method using two distinct applications to human cardiac dynamics.
We demonstrate the predictive value of ODF-based scores for the early detection of lesions that will appear or heal.
We demonstrate the use of interpretative narrative representation of data for purposes of cultural brokering.
We demonstrate the viability of the tissue and labeling with specific markers of hair cell function and of ion homeostasis in the epithelium.
We demonstrate this approach with data from a short telephone-administered neuropsychological battery given to a large , neurologically healthy sample aged 45-85 years old.
We demonstrate β2GPI in the retina and choroid of patients with AMD.
We derived and compared @number@ prediction models.
We derived latent constructs representing four neuropsychological domains , a measure of cognitive reserve , and a measure of brain reserve.
We derived measures of overall TUG performance and different subtasks including transitions ( sit-to-stand , stand-to-sit ) , walking , and turning.
We derived @number@ \ "pathway phenotypes \ " that summarized patterns of variation across @number@ KEGG pathways ( five phenotypes per pathway ) .
We derive such a distribution and demonstrate its accuracy in modeling human longevity data from life tables.
We describe a biobanking system that is a platform for discovery research at the Center for Neurodegenerative Disease Research at the University of Pennsylvania.
We describe a constrained prose recall task that attempts to lay the foundations for a test suitable for detecting ALF sensitively and economically.
We describe alterations in hippocampal plasticity , which occur in both chronic stress and AD including dendritic remodeling , neurogenesis , and long-term potentiation.
We describe an 18-year-old male with cervical flexion myelopathy with Hirayama disease-like features who showed apparent long tract signs.
We describe an answer to the challenge that combines @number@ emerging treatment models in an academic setting : hospital-based physicians and outpatient parenteral antimicrobial therapy.
We describe and discuss pathologic findings and provide a detailed histology of the teeth which had to be extracted during initial treatment.
We describe a novel multiplexed probe-based non-PCR method for TL measurement.
We describe a pair of monozygotic twins with an attenuated form of mucopolysaccharidosis type I ( MPS-I ) .
We describe a statewide effort to implement and disseminate A Matter of Balance / Volunteer Lay Leader model , an evidence-based fall-prevention program.
We describe a subset of drug candidates that interferes with the APP-ApoE interaction and returns the parameters noted above to normal.
We describe a suggestive case report of PD associated with mild cognitive impairment ( MCI ) and falls.
We describe cell-type- and patient-specific transcriptional hierarchies.
We describe clinical and pathologic findings of seven monozygotic ( MZ ) and dizygotic ( DZ ) twin pairs.
We describe different in vitro and in vivo systems that can be used to study molecules , pathways and cells that are involved in osteoarthritis.
We describe here how recent advances in dissecting cognitive deficits from a systems-perspective have contributed to a non-neurocentric understanding of its pathogenesis and treatment strategy.
We describe here its content and interface , and discuss how it can help to unravel the genetics of human longevity.
We describe here the diversity of microglia phenotypes and their responses in health , aging , and disease.
We describe here the synthesis and characterization of compound @number@ a new potent and brain penetrating CB2 ligand based on an original triazine template.
We describe in this report the conceptual design of a new taxonomy of uncertainties around the use of CNGS in health care.
We describe our experience with this technique , using heart rate as an indicator of adequate anesthetic depth.
We describe our perioperative results defined as surgical and safety oncology variables.
We describe selected applications that analyse the physics of communication and use energy efficiency as a central tenet.
We describe several behavioral assays that can be used in rodent models to augment disc degeneration measurements and characterize different types of pain.
We describe several opportunities for physicians to take leadership on this issue.
We describe subconjunctival prolapse of orbital fat as an uncommon clinical association of TAO.
We describe the bacterial taxa present in different locations of the GI tract , and their specific metabolic features.
We describe the characteristics of the current smokers ( n = @number@ ) .
We describe the clinical utility of 18F-fluorodeoxyglucose positron emission tomography ( FDG-PET ) / CT scanning for diagnosing neuro-myelomatosis.
We describe the design of a large-scale , stepped-wedge , cluster-randomized trial of the Veteran-Directed Home- and Community-Based Services ( VD-HCBS ) program.
We describe the development of Australia's first age-specific early intervention protocol.
We describe the development of VENNTURE , a program that facilitates visualization of up to six datasets in a user-friendly manner.
We describe the diagnoses , clinical characteristics , and outcomes of patients who were elderly at the time of ILD diagnosis.
We describe the evolution of the GHCC-COAH partnership through the \ "Courtship Model. \ "
We describe the identification , adaptation and validation of some theses measurements.
We describe the identification of homozygous and compound heterozygous mutations in TGDS in seven unrelated individuals with typical Catel-Manzke syndrome by exome sequencing.
We describe the main anti-biotic-resistant isolates for surgery and the mechanisms to avoid the development of bacterial resistance.
We describe the methods for assessment of protein status , and outcomes related to protein nutritional support for critically ill patients.
We describe the morphologic features of the pocket in normal individuals.
We describe the physiology of aging and its effect on elderly , critically ill , surgical patients.
We describe the process of translating tasks used in functional neuroimaging to tests for assessing individual differences.
We describe the protocol of a large randomised controlled trial ( RCT ) of Levothyroxine treatment for SCH.
We describe the role of IL-7 and its receptor in immunosenescence , the aging of the immune system.
We describe the structure and present situation of the Chinese healthcare system and discuss its primary problems and challenges.
We describe the temporal trends in the demographic and clinical characteristics of HIV-positive patients initiating ART in 2003-13 within an Asian regional cohort.
We describe the two-staged fine mapping of a previously identified linkage peak for knee strength on chr12q12-14.
We describe three such cases of embolization of CCFs through SOV , and their results.
We describe two cases of delirium in hospitalized older patients , supporting the \ "cholinergic deficiency hypothesis \ ".
We designate this strain as SAMP10 / TaSlc-Slc5a2 ( slc ) ( SAMP10-ΔSglt2 ) .
We designed a cohort study to identify individuals presenting accelerated and premature arterial aging in the Portuguese population.
We designed a FOXO4 peptide that perturbs the FOXO4 interaction with p53.
We designed model submissions to help volunteers tailor a proposal and recruited caregiver advocates participating in their state process.
We designed multi-component lipid models to mimic healthy and diseased states of the neuronal membrane.
We designed our review using the neo-institutional framework of Greenwood and Hinings ( @number@ ) .
We designed this retrospective study to assess effect of HCV on the outcome of patients with AH.
We designed this study to determine the pharmacokinetics of intravenous paracetamol in very old patients and to compare them with that of younger patients.
We designed this study to determine whether physical activity is associated with healthy ageing in later life.
We detail the advantages for both patient and analyst of this concept , which may be particularly useful for elderly patients.
We detected a significant age effect on the posterior regions of hippocampi while there is no gender effect present.
We detected a soluble Nogo-a product in the cerebral spinal fluid of patients with NPSLE.
We detected increased cellular and secreted levels of Wnt5a in PGRN-deficient lymphoblasts associated with enhanced phosphorylated calmodulin kinase II.
We detected indels in FUS exons @number@ @number@ @number@ and @number@ with similar frequencies in patients ( @percent@ ) and controls ( @percent@ ) .
We detected no influence between surgeons on clinical voiding parameters and postoperative sexual function after TURP using the IPSS and IIEF-15 questionnaires.
We detected no inhibition of hepatocyte proliferation after CCl ( @number@ ) injury in 15-month-old mice , whereas it was inhibited after a partial hepatectomy.
We detected significant ICAM-1 hypermethylation in cancer cases ( P = @number@ ) @number@ to @number@ years prediagnosis.
We detected the expression of adiponectin receptors ( AdipoR1 and AdipoR2 ) mRNA in cultured dermal fibroblasts.
We detected the expression of p-tau and GSK3B , a physiological kinase of tau , in neuronal cells derived from AD-iPSCs.
We detected the genotypes of rs12456492 in @number@ PD patients and @number@ control subjects from a Han Chinese population.
We detect robust HDAC3 expression in neurons and glia in the cerebellum and an increase in the levels of HDAC3 in SCA7 mice.
We determined all-cause mortality and CV mortality at a 3-year follow-up.
We determined associations in potential confounder and mediator-adjusted mixed regression models.
We determined HAND diagnoses by consensus panel and all participants underwent magnetic resonance spectroscopy ( MRS ) to measure markers of brain injury.
We determined how often applying the TBS adjustment to fracture probability altered treatment qualification.
We determined if poor balance and decreased gait speed may predict mortality after adjustment for both baseline and follow-up confounders in well-functioning elderly women.
We determined in a prospective population-based cohort ( NEDICES ) in elders whether hypercholesterolemia was associated with slower cognitive decline.
We determined prevalence rates for mental illnesses and related comorbidities among all inmates in a state prison system.
We determined that C. elegans RalGAP loss decreased lifespan , consistent with a Tsc-like function.
We determined that cortical thinning normally starts in women at age @number@ years and accelerates thereafter.
We determined that institutionalization is mitigated by use of in-home services.
We determined that SFN stimulates proteasome activity and autophagy in normal and HGPS fibroblast cultures.
We determined the association between heart rate at rest and endothelium-dependent vasodilation in @number@ apparently healthy adults ( 18-63 years ) .
We determined the body mass index and recorded two blood pressure measurements that were averaged for analysis.
We determined the clinical characteristics and prevalence of each ATN profile in cognitively unimpaired individuals aged @number@ years and older.
We determined the costs and effects of routine genotyping for old aged Dutch depressed inpatients.
We determined the effect of aging on expiratory flow limitation ( EFL ) and operating lung volumes when matched for lung size.
We determined the effect of aging on lung function and cellular / molecular changes of 8- to 32-month old mice.
We determined the frequency of occurrence and dynamism of the mentioned retrograde lesions.
We determined the frequency of the C9ORF72 hexanucleotide repeat expansions in a population of @number@ patients with schizophrenia or schizoaffective disorder.
We determined the influence of n3-PUFA on muscle mitochondrial physiology and protein metabolism in older adults.
We determined their actual ability as the probability of stepping inside the path over a range of path widths and speeds.
We determined the miRNA profiles in laser microdissected DA neurons from postmortem sporadic PD patients ' brains and age-matched controls.
We determined the optimal concentration of glyoxal to induce AGEs formation identified by carboxymethyl-lysin expression while keeping their toxic effects low.
We determined the relationships between these biomarkers , the CSF AD biomarkers concentrations , and the clinical sleep profile.
We determined the relative ratio of telomere repeat copy number ( T ) to single-copy gene copy number ( S ) .
We determined the thymic output by the T cell receptor excision circle ( TREC ) content and percentage of CD31 + naïve T cells.
We determined whether acute inhibition of TNF-α improves vascular endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women.
We determined whether baseline poor self-rated health was associated with increased risk of incident ET.
We determined whether Brugada-ECG was present and assessed standard ECG measures ( heart rate , PQ- , QRS- , and QT-intervals ) .
We determined whether ET is associated with MCI.
We determined whether pulse wave velocity ( PWV ) , marker of arterial stiffness , was associated with skeletal muscle decline.
We determined whether sensitivity to linear sine-wave gratings and to an elementary stimulus preferentially processed in extrastriate areas could be distinctively affected by aging.
We determined whether sex and diabetes were factors associated with the response to exercise rehabilitation in patients with claudication.
We determined whether the structural characteristics of human aortic adventitial collagen change with aging , location , and aneurysm formation.
We determine that global protein synthesis is elevated as a consequence of activated nucleoli and enhanced ribosome biogenesis in HGPS-derived fibroblasts.
We determine that SIRT4 enzymatically hydrolyzes the lipoamide cofactors from the E2 component dihydrolipoyllysine acetyltransferase ( DLAT ) , diminishing PDH activity.
We determine the effects of adiposity on systemic IT tolerance in aged compared with young obese mice.
We develop a discrete variant of a general model for adult mortality influenced by the delayed impact of early conditions on adult health and mortality.
We develop a novel theory to explain the complexity of aging in mammals and perhaps in other organisms.
We developed a blast neurotrauma mouse model that recapitulated CTE-linked neuropathology in wild-type C57BL / 6 mice @number@ weeks after exposure to a single blast.
We developed ActiveLifestyle , an information technology ( IT ) -based system for active and healthy aging aiming at improving balance and strength.
We developed a culturing system , based on a papain-aided procedure , for resected adult human brain tissue removed during neurosurgery.
We developed a data-analysis pipeline that identifies with high confidence somatic variants that accumulated in vivo in the original ASC.
We developed a model for the iron uptake system with a higher predictive capacity than classic biochemical models.
We developed an advanced partial volume correction ( PVC ) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity.
We developed an equation to assess individual FAS values using the first principal component derived from principal component analysis.
We developed a neuropathological comorbidity ( NPC ) score and compared it to CDR , IQCODE , and NPI scores.
We developed an immunofluorescence assay to quantitatively detect , at the single cell level , changes in the nuclear content of chromatin-associated proteins.
We developed an online confidential survey conducted from @date@ , to @date@ .
We developed a non-randomized statewide trial , Falls Free PA , to assess its effectiveness in reducing falls incidence over @number@ months.
We developed a novel cell-based ELISA to evaluate cellular response to estrogenicity by reduction of soluble-COMT expression in ER-positive MCF-7 cells exposed to estrogenic compounds.
We developed a novel statistical methodology to identify age-regulated expression trends in cross-sectional datasets.
We developed a rabbit model of chronic prostate ischemia by creating aorto-iliac arterial atherosclerosis.
We developed a RV extension of the generalized disequilibrium test ( GDT ) to analyze sequence data obtained from nuclear and extended families.
We developed a semi-automated algorithm to quantify lower leg arterial calcifications ( LLACs ) , captured by HR-pQCT.
We developed a semi-automated macro in ImageJ software to allow for more efficient quantification of sprouting area.
We developed a simple Spatial Working Memory and Attention Test on Paired Symbols ( SWAPS ) .
We developed a statistical model to show how both intrinsic mutation rate and selfish selection contribute to the mutational burden borne by the paternal germline.
We developed a system for monitoring costs from individual patient data on a national level in Finland.
We developed a system that allows for in vivo imaging of the same neurons over months.
We developed a targeted re-sequencing assay combining high-throughput with ultra-high sensitivity based on single-molecule molecular inversion probes ( smMIPs ) .
We developed a variety of new approaches to define the steps in the processing of these overhangs.
We developed a Web-based calculator to facilitate its use.
We developed clinically applicable reference values in relation to the nerve distributions of the feet.
We developed gender-specific , age-dependent reference values of bone density for Central European children.
We developed hierarchical logistic regression models to analyze predictors of in-hospital mortality , and validated the models using the bootstrap method.
We developed @number@ recommendations.
We developed the Italian version of the Dimensional Apathy Scale ( I-DAS ) and explored its psychometric properties in a sample of @number@ healthy individuals.
We developed visualizations of smart home health data integrated into a framework of wellness.
We diagnosed @number@ ( @percent@ , @percent@ CI @number@.3-5.8% ) participants with dementia.
We did a 1-year follow-up to quantify the cognitive decline by recording changes in the Clinical Dementia Rating score.
We did a meta-regression analysis.
We did analyses by intention-to-treat and assessed adverse events.
We did a review of the literature data of main Russian publications and databases PubMed / Medline for the last @number@ years.
We did association analyses in all participants with dementia with Lewy bodies , and also only in participants with pathological diagnosis.
We did a systematic review with the aim of describing seroprevalence and susceptibility in the general population or special groups in the EU and EEA.
We did detect a dose-dependent inhibitory effect of Wnt16 on WNT1 activation of this canonical WNT pathway.
We did , however , observe an age-related increase in both apoE isoforms.
We did MRI and generated cortical and subcortical volumes using a parcellation of the volumetric T1-weighted scan.
We did not detect an association between testosterone and cognitive performance.
We did not detect any association of the other two SNPs in pri-miR-26a-1 ( rs7372209 ) and pri-miR-100 ( rs1834306 ) with cervical cancer risk.
We did not detect any significant differences in the QoL- or appetite scores between the two study groups after three months.
We did not detect a synergistic association of co-occurring HIV and obesity on IL-6 or sCD14 elevation.
We did not find age ≥70yo as an independent risk factor for mortality in ICU.
We did not find an association between p.R47H and age of onset of AD or family history of dementia.
We did not find an association of PF or AVF with carotid or cerebral atherosclerotic burden.
We did not find any brain regions in which UQ had lost more gray matter than SQ over @number@ years.
We did not find any significant correlations between behavioral and MO-VEP measures.
We did not find any significant differences between pre-chemotherapy and post-chemotherapy bacterial composition and abundances.
We did not find a significant difference between men and women or between smokers and non-smokers.
We did not find a statistically significant association of 25-hydroxyvitamin D concentration with mortality.
We did not find evidence for an association with variants at the OBFC1 locus or other loci reported to be associated with telomere length.
We did not find evidence for our hypothesis that intracellular cofilin rods are localized to tau-positive neuropil threads.
We did not find evidence of altered longitudinal trajectories based on clinical outcome within the high risk cohort.
We did not find evidence of dominant toxicity from any variant form including the pathogenic D620N mutation , even with aging.
We did not find higher income associated with SA.
We did not find nNOS-positive fibers in any of these muscle-nerves.
We did not find significant between-group differences in FA and AD.
We did not find significant differences between centenarians and the control group ( P > @number@ ) .
We did not find significant differences in volume and mean kurtosis ( MKT ) between groups.
We did not find strong interaction effects between number of comorbidities and dementia severity.
We did not find such association among the women.
We did not find systematic differences in grandparental age distribution between the studied groups.
We did not have specific hypotheses regarding the relationship between leukocyte telomere length and hippocampal volume , due to conflicting reports in the published literature.
We did not identify any additional loci significantly associated with age at menopause in African Americans.
We did not identify any RE in these patients , indicating that C9orf72 is in all probability not involved in the pathogenesis of these disorders.
We did not identify deficits in executive functioning in our sample of premutation carrier males with motor symptoms.
We did not identify differences in rs-fc within HIV-infected individuals by HAND status.
We did not identify gender specific differences.
We did not observe any abnormal blood pressure responses to either the 1RM testing or maximal repetition testing sessions.
We did not observe any association in men.
We did not observe any example of the A673T variant in our large sample.
We did not observe any significant associations between the studied genetic variants of VDR and the risk of PD.
We did not observe any significant per-allele trends among the @number@ diabetes-related SNPs examined in relation to glioma risk.
We did not observe calcification even though after @number@ days of dox-treatment many other markers characteristic for senescent cells were present.
We did not observe changes in either cohort for free-water-corrected fractional anisotropy or free-water-corrected mean diffusivity.
We did not observe differences between groups in terms of signs and symptoms suggestive of depression according to the Geriatric Depression Scale.
We did not see modification by ALAD or an association between bone lead and change in tremor score over time.
We did not use any date or language restrictions in the electronic searches for trials.
We didn't observe any serious complications such as skin necrosis , deep infection , osteomyelitis and failure of metalwork.
We did so by using cohort members ' polygenic profile score for education to predict their parents ' longevity.
We directly compared @number@ arterial spin-labeling techniques in healthy elderly controls and individuals with mild cognitive impairment.
We directly verify PHLPP1α inhibits AKT in hippocampal neurons and demonstrate a novel role for PHLPP1β / SCOP , to promote AKT activation.
We disagree with their propositions for several reasons.
We discontinued the program after @number@ months due to staffing limitations and competing priorities.
We discourage use of CAVE for testing multivariate hypotheses about behavioral development.
We discovered a novel glioblastoma control module centered on four major network hubs : Huntingtin , HNF4α , c-Myc and 14-3-3ζ.
We discovered a novel tau aggregation inhibitor , and elucidated the inhibitory mechanism of the compound on tau aggregation.
We discovered that , in mouse models , activated B-lymphocytes infiltrate infarcted tissue in the weeks after stroke.
We discovered that the presence of cholesterol , LDLR-mediated cholesterol endocytosis , and cholesterol efflux are all essential to NCEH-1-mediated neuroprotection.
We discovered that VSMCs co-cultured with senescent ECs exhibited decreased susceptibility to H₂O₂-induced apoptosis compared with those co-cultured with young ECs.
We discuss about underlying mechanisms and the possible implications in the treatment of CVD.
We discuss and speculate on potential roles of dermal adipocytes in cutaneous biology with an emphasis on communication during hair follicle growth and wound healing.
We discuss approaches for quantifying reserve with latent variable models , with emphasis on their application in the analysis of data from observational studies.
We discuss cognitive reserve and possible mechanisms that drive neuroplasticity and new learning.
We discuss CRTC deregulation as a new driver of aging that integrates the link between age and disease risk.
We discuss current progress and outline issues for further research in these fields.
We discuss cyclooxygenases , prostaglandins , thromboxanes and also iron in PD.
We discussed the possible underlying mechanisms for the age-related degradation in sleep-based memory consolidation.
We discuss factors to consider when designing interventions for reducing sunk-cost bias.
We discuss here the current evidence linking the Arf / p53 pathway to the processes of aging and cancer through stem cell regulation.
We discuss how Mn requirements intersect with Mn biology and toxicity , and how these requirements may be altered in neurological disease.
We discuss how the finding of structural violence emerged and also the deeper meaning , context , and insights resulting from our combined methods.
We discuss how these patterns of normative social network development inform research in social , evolutionary , cultural , and personality psychology.
We discuss how to make an accurate diagnosis for appropriate management.
We discuss how to select genetic variants to study.
We discuss implications for future interventions to change negative age-related stereotypes.
We discuss implications for models of cognitive aging and suggest that it is necessary to include more explicitly special social abilities in those models.
We discuss implications for stigma theory , and the ways that stigma exits and entries affect psychological well-being.
We discuss implications for theory on personality development across the lifespan.
We discuss implications , possible explanations , and likely future scenarios.
We discuss important findings from other fields and draw parallels to the practice of medicine.
We discuss important implications of these findings to further our understanding of strategic variations during cognitive aging.
We discuss its recruitment to kinetochores , its assembly into the inhibitor of anaphase progression , and the importance of its posttranslational modifications.
We discuss multimodal neuronavigation , supra-maximum tumor resection , and the postoperative treatment gap.
We discuss our findings in terms of their relevance to attentional processes and brain-based models of emotional well-being and aging.
We discuss our results in light of the current hypothesis of a functional segregation in priming processes.
We discuss our results with regard to the putative roles of CREM in brain development and in cognition.
We discuss possible age-related differences in the processes used to create emotional and nonemotional integrations.
We discuss possible causal social and biological pathways.
We discuss possible causes for reduced neurogenesis with age , its consequences on cognition , and how neurogenesis might be restored in old age.
We discuss possible explanations for the lack of age effects and consider implications for applied and clinical settings.
We discuss possible pathways by which common and often severe late-life challenges may undermine an otherwise relatively robust self-esteem system.
We discuss possible scenarios through which Dicer / Drosha / microRNAs could enhance translation.
We discuss potential opportunities to assess the impact of anti-inflammatory interventions on arterial stiffness in subjects without primary inflammatory conditions.
We discuss putative mechanisms for blood-borne brain rejuvenation and suggest promising avenues for future research and development of therapies.
We discuss recent advances in our understanding of molecular clocks and highlight their relevance to human physiology and disease.
We discuss recent developments in the CFS field ; in particular , the role of DNA structure-specific endonucleases in promoting cleavage at CFSs.
We discuss recent findings that provide insight into the cross-talk between this critical regulator of metabolic homeostasis and molecular mechanisms that promote longevity.
We discuss several methodologies for assessing ADSC mitochondrial function and structural changes under environmental cues , in particular , increased ROS caused by hyperglycemia.
We discuss similarities to episodic memory development and address open questions for future research.
We discuss some aspects of TDHC's aging and its possible effects on fibrinogen adsorption.
We discuss some implications and nuances of our findings.
We discuss some recent findings suggesting heterogeneity within the hippocampal stem cell pool and the regulation of activation of quiescent stem cells.
We discuss strategies for improving people's motivation to complete numeracy measures and other numerical tasks.
We discuss that suppression of geroconversion in confluent and contact-inhibited cultures mimics gerosuppression in the organism.
We discuss the biomechanical basis for IOP-driven changes in connective tissues , blood flow , and cellular responses.
We discuss the challenges physicians face in administering the optimal amount of protein and amino acids.
We discuss the concept that peripheral and central nervous system inflammation link the pathogenesis of AD and metabolic diseases.
We discuss the consequences of aberrant interactions between age-related RBP aggregation and disease-associated RBP aggregation.
We discuss the constraints of a cross-sectional design and other methodological issues , and indicate future directions.
We discuss the geneticist's role in the diagnosis of rare dysmorphic syndromes and their genetic counseling.
We discuss the implications for the well-being of older widow ( er ) s and adult children.
We discuss the implications of the findings for policy and practice.
We discuss the implications of these findings for policy debates about data privacy , financial literacy , and early childhood interventions.
We discuss the implications of these findings for theories of age-related declines in mind wandering.
We discuss the implications of these results for emotion theories of aging.
We discuss the implications of these results for MCI diagnosis and categorization.
We discuss the importance of preoperative counselling and surgical planning to provide the patient with a satisfactory outcome.
We discuss the importance of such studies about the gender's differences in aging.
We discuss the initial consultation , relevant anatomy for the dermatologist , and medical , laser and cosmetic therapies.
We discuss the limitations in investigating the pathophysiology of frailty due to few relevant experimental models.
We discuss the link between having one or more mental disorders and a negative evaluation of perceived health and quality of life.
We discuss the mechanisms regulating necroptosis and its potential role in inflammation and disease.
We discuss the mechanisms responsible for the generation and maintenance of these subsets and how age-related changes can be delayed or prevented by clinical interventions.
We discuss the methods for each , and consider likely sources of bias , such as reverse causation and confounding.
We discuss the molecular mechanisms involved in muscular dystrophy and in muscle atrophy and present current strategies aimed at ameliorating these diseases.
We discuss the most important age-related morphological and biological changes that affect articular cartilage and chondrocytes.
We discuss the policy implications implied by our cohort measures.
We discuss the possibility of exploiting , in rapidly growing tumours , acute cell death by ' metabolic catastrophe'.
We discuss the possible correlation between these @number@ findings and review the available literature on Lambl's excrescences and tiger stripes.
We discuss the potential utility of personality measurement to function as an inexpensive and accessible tool for health care professionals to personalize preventive medicine.
We discuss the potential utility of this method in detecting neurophysiological impairments in disease and monitoring neurophysiological changes in response to an intervention.
We discuss the present results in the context of neuroanatomical and process-oriented theories of how memories age.
We discuss the prospects of modulating canonical and non-canonical Wnt signaling as a strategy for neuroprotection.
We discuss the results in relation to amnesia , aging , and compensatory mechanisms.
We discuss the results in terms of age-related changes in the perception and control of dynamic body orientation.
We discuss the role of the PDBP in PD biomarker identification and present guidelines to facilitate their development.
We discuss the role of vocabulary funds and controlled access in naming pictures throughout life.
We discuss these complex , multidimensional findings , the variation among caregivers , and present implications for practice , policy , and research.
We discuss these findings in relation to relevant literature of successful aging , the perception of time , eudaimonic and hedonic well-being and generativity.
We discuss these findings in terms of the influences of both bias-inhibition processes and school acquisitions.
We discuss these findings in the context of a contemporary model of cognitive control.
We discuss these findings in the light of cognitive models of human navigation and aging.
We discuss these findings within the framework of inhibitory control theory in cognitive aging and its implications for age-related changes in speech perception.
We discuss these \ "offbeat \ " muscle stem cells and their status as adult skeletal muscle stem cells vis-a-vis satellite cells.
We discuss these results in light of the known function of CST1 as a potent inhibitor of lysosomal cysteine proteases.
We discuss these results within a working memory gating framework for abstract rule-guided behavior.
We discuss the various mechanisms by which cardiovascular risk factors cause vascular remodeling.
We discuss the vascular effects of factors common to many patients undergoing muscle biopsy , for example , diabetes mellitus , hypertension , and aging.
We discuss this important concept as well as several potential countermeasures that may compress the period of morbidity in old age.
We discuss tradeoffs between maintaining fidelity to the EBIs while maximizing fit to the new context.
We discuss transcription factors and signalling cues governing stem cell function of satellite cells and heterogeneity in the satellite cell pool.
We discuss whether telomere shortening is related to negative health outcomes later in life or could be a biomarker predicting health outcomes.
We discuss whether these age-related differences in brain activation benefit performance in older adults , and additional considerations.
We dissected @number@ tracts including U-shaped fibers.
We distinguished pro-inflammatory haplotypes associated with low IL-10 production capacity and anti-inflammatory haplotypes with high IL-10 production capacity.
We distributed an instruction manual on steps of selected yoga practice for the women's self-reference at home after the @number@ days of continuous yoga practice.
We divided subjects into rice , bread , and both groups according to their breakfast staple.
We divided the patients into @number@ groups according to their age.
We divided the SRH-global and SRH-age into three levels-high , middle , and low-and combined each into nine new categories ( SRH-combi ) .
We documented inhibition of phosphorylation of p190 by EGFR-TKI treatment in lung adenocarcinoma cell lines.
We document here direct evidence for a phosphorylated hAChE refractory to oxime reactivation , although we observed no aging.
We document here the strategies currently developed to transfer DNA of interest into mitochondria.
We document that declines in muscle mass and bone density are likely to be the mechanism through which these effects are operating.
We do not find an association of mortality with either absolute LTL or LTL attrition.
We do not , however , view dyadic interviews as miniature focus groups , and treat them as generating their own opportunities and issues.
We do not know how overall or diagnosis-specific hospitalization rates compare between HIV-infected and uninfected individuals or what conditions may drive hospitalization trends.
We do not know how the impairment of autophagy or UPS leads to the disturbance in cellular homeostasis and contribute into cellular aging and neurodegeneration.
We do not recommend anterior pelvic external fixation in elderly because of the risk of pin track infection and pin loosening.
We do this job by analyzing the fractal dimension of DNA walk and face during human aging.
We draw on estimates and analyses from the National Transfer Accounts project to illustrate and quantify these points.
We draw on secondary analysis of qualitative data collected through in-person interviews with @number@ home-care nurses from a western Canadian health authority.
We draw trajectories of life quality measured using CASP-19 over eight years.
We easily visualized the hyoid bone trajectory by using ultrasonography.
Weekday and weekend sleep onset and offset and weekend-weekday differences were derived from actigraphy.
Weekday sleep offset shifted earlier with age in the younger cohort and later in the older cohort after age @number@
Weekday total activity counts decreased @percent@ ( P < 0.05 ) following WL.
Weekend-weekday sleep offset differences increased with age in the younger cohort and decreased in the older cohort after age @number@
Weekly morbidity and dietary intake surveillance was carried out during the second half of infancy.
We elaborate on some systems biological approaches deployed in one of the projects of the consortium ( ROSage ) .
We elaborate on two categories that contribute to cellular dysfunction : cell extrinsic and intrinsic factors.
We emphasized articles of the highest scientific level , combining radical cystectomy and perioperative chemotherapy with curative intent to affect overall and disease-specific survival.
We emphasize importance of considering such effects in both aging research and disease prevention.
We emphasize NIRS may be a useful tool for objective assessment of anxiety levels.
We emphasize @number@ such modifiers , the genetic risk factor apolipoprotein E and an age-related endocrine change , low testosterone.
We emphasize recent insights that highlight the greatest contrasts or similarities in the pathogenesis of these two chronic lung disease phenotypes.
We emphasize that multiple mitochondrial signaling pathways , besides mitochondrial ROS , can induce cellular senescence.
We emphasize that planning for chronic care requires equal attention to the complexity of all four components.
We emphasize the importance of chromatin remodelling in this regulation.
We emphasize the importance of training Kenyan clinician-investigators who will ultimately lead efforts in CVPD care , education , and research.
We emphasize two main results.
We employ both continuous and categorical measures of age to test for a potential moderating effect.
We employed additional measures that allow non-parametric assessment of performance ( Townsend's capacity coefficient ) and parametric estimates ( Linear Ballistic Accumulator model ) .
We employed a mixed methods design using data from medical charts , electronic records , and semi-structured interviews.
We employed a murine model of influenza infection to identify these mechanisms.
We employed an integrative epigenomic RVAM for variants with allele frequency < 1%.
We employed a pneumatic artificial muscle as the actuator so that flexible assistance with low rigidity can be achieved.
We employed correlational analyses to evaluate the burden of WMH and the relationship between WMH and cognitive function.
We employed multiple logistic regression analyses to examine the associations between the sociodemographic characteristics and incident EA.
We employed the Functional Assessment of Chronic Illness Therapy ( FACIT ) Measurement System and the Care Dependency Scale.
We employed two different cellular models : MCF-7 cells undergoing senescence progression and human fibroblasts in a state of replicative senescence.
We encountered a 67-year-old white male patient with suspected amiodarone pneumonitis characterized by multiple lung nodules associated with pleural and pericardial effusion and peripheral neuropathy.
We encourage further research in order to confirm a relationship between semen quality and increased risk for CM.
We encourage health care professionals to proactively address sexuality and extend knowledge about safe sex and sexual function to older adults.
We encourage investigators to carefully consider additional or alternative measures of bioenergetic function in studies of life-history trade-offs.
We end by discussing the exciting new concept of possibly reversing the HSC aging process along with outstanding questions that remain to be answered.
We end with a discussion of therapeutic approaches to prevent these deleterious effects.
We engineered a bacterial expression system for the split-Renilla luciferase ( RL ) complementation assay that monitors PPI.
We enrolled @number@ C9orf72 and @number@ disease severity-matched sporadic MND patients , and @number@ controls.
We enrolled @number@ elderly subjects ( @number@ men , @number@ women ) with a mean age of @number@ ± @number@ years.
We enrolled @number@ healthy Malagasy subjects aged 18-73 years ( @number@ males ) from @date@ to @date@ .
We enrolled @number@ men and @number@ women , with a sex-ratio of @number@
We enrolled @number@ pathologist participants whose practice included the interpretation of MSLs.
We enrolled @number@ patients diagnosed with clinical early ( International Federation of Gynecology and Obstetrics stages I-II ) type I endometrial cancer.
We enrolled @number@ patients from @number@ hospital admissions.
We enrolled @number@ patients ( @number@ % male ; mean age @number@ ± @number@ years ) at Fukuoka University Hospital.
We enrolled @number@ patients with childhood intellectual disability and young-onset parkinsonism ( ≤40 years at onset ) and @number@ patients with infantile neuroaxonal dystrophy.
We enrolled @number@ subjects who underwent pulmonary function test before preoperative examination in our study.
We enrolled @number@ young ( @number@ ± @number@ yr ) and @number@ old ( @number@ ± @number@ yr ) right-handed participants.
We envision this system to be a great candidate to substitute current mitochondrial assay systems.
We established a murine model of thymic involution induced by stereotactically placed electrolytic lesions in the anterior hypothalamic area.
We established an acute and chronic PD model in nonuremic and uremic rats.
We established a prospective study with @number@ patients to evaluate the patients ' pain levels during the prehospital phase of treatment and prehospital analgesic therapy.
We established cut-off points for timed walk ( 5m / 3s ) and pulse pressure ( @number@ mmHg ) .
We established pathological and molecular mechanisms that link the disease to mitochondrial dysfunction and oxidative stress.
We established the prevalence of MPS in a community-dwelling elderly population sample in Japan.
We estimated 1-year PM RESULTS : Sulfate and ammonium were selected by the LASSO in the Horvath DNAm-age models.
We estimated a cost of $ 9194 for meeting time to develop the project.
We estimated age- and gender-specific prevalence of COPD using a multilevel mixed-effect logistic regression.
We estimated age-standardized disability prevalence by educational attainment and state.
We estimated a @percent@ gain in statistical power with long-term average ( LTA ) as compared to single-visit BP association studies.
We estimated bias and threshold for the two methods , and found that neither measure differed across the methods.
We estimated contributions of care-delivery site and comorbid conditions ( including and excluding neuropsychiatric diagnoses ) to between-category cost differences.
We estimated costs per unit of care from hospital information systems and national data sources.
We estimated crude and adjusted odds ratios ( OR ) and @percent@ confidence intervals ( CI ) using conditional logistic regression analysis.
We estimated frailty prevalence in the overall sample and by sociodemographics.
We estimated free hormones by mass action.
We estimated how becoming hypertensive and increasing age at onset and duration since hypertension initiation affect cognition.
We estimated levels of bioavailable 25-hydroxyvitamin D in homozygous participants.
We estimated life expectancies by using a model that combined age , sex , and comorbidity.
We estimated lifetime costs of publicly funded social care , covering services such as residential and nursing care homes , domiciliary care and meals.
We estimated multinomial logistic models of the direction and linear regression models of the amounts of OOP changes over survey periods.
We estimated @number@ nationwide age-specific hospitalization rates using data from the Nationwide Inpatient Sample and Census data.
We estimated odds ratios from multiple logistic regressions , comparing the likelihood of outcome variables across @number@ groups of patients.
We estimated ordinal and multinomial logistic regressions that controlled for health care utilization , current health , and recent family deaths.
We estimated prevalence of complications ( retinopathy , nephropathy , neuropathy , and peripheral vascular disease ) .
We estimated that each year , @number@ hospitalizations and @number@ deaths are related to domestically acquired Salmonella in seniors.
We estimated the accuracy of VFA and WC for identifying at least two of these factors by receiver operating characteristic ( ROC ) curve analysis.
We estimated the annual number of cancers in the HIV-infected population , both with and without AIDS , in the United States.
We estimated the change in erectile function with time using locally weighted scatterplot smoothing.
We estimated the hazard ratio for mortality risk by Cox regression analyses.
We estimated the heritability of a longitudinal battery of computerised cognitive tests including speed measures , using a classical twin design.
We estimated the inbreeding coefficient in Caribbean Hispanics and examined its effects on risk of late-onset Alzheimer disease.
We estimated the magnitude of confounding by LC for common risk factors and diseases.
We estimated the odds of MetS per 1-s.d. increase in VAT and LF , adjusting for key covariates.
We estimated the prevalence and used logistic regression models to identify factors associated to hypertension.
We estimated the prevalence of frailty and examined associations with morbidity and mortality.
We estimated the prevalence of H. pylori infection by sex , birth year , and geographic area among Japanese adults.
We estimated the ratio of observed to expected numbers of cancers , the standardized incidence ratio ( SIR ) .
We estimated the sex- and index-age-specific lifetime risk of incident diabetes , after adjusting for the competing risk of death.
We estimated the use of various health care services by the groups while adjusting for clinical and sociodemographic characteristics.
We estimated unadjusted associations between Fried's frailty score and incident disability at 1-month and 6-month mortality using Cox proportional hazard models.
We estimated white matter fractional anisotropy , mean diffusivity and hippocampal structural connectivity in two independent cohorts.
We estimate patients harboring approximately @number@ years of premature telomere loss compared to healthy aged-matched subjects at the time of AML onset.
We estimate that in the absence of any pharmaceutical innovation , mean age at death would have increased by only @number@ years.
We estimate that pharmaceutical innovation has reduced the number of hospital days by approximately @percent@ per year.
We estimate the causal effect of hearing loss on early retirement via disability benefits , taking into account the endogeneity of functional hearing.
We estimate the proportion of male Mexican return migrants who contributed to the U.S. social security system and analyze their socioeconomic characteristics and migration histories.
We estimate the proportion of staphylococcal infections that are caused by strains containing the PVL genes , and describe risk factors for these infections.
We estimate these models using impulse-response analysis and variance decomposition.
We evaluated advancing age as a predictor of neurocognitive impairment in a large cohort of previously ART-naive individuals on long-term ART.
We evaluated a goal-setting intervention aimed at promoting increased cognitive and physical activity and improving mental and physical fitness , diet and health.
We evaluated a large administrative database to determine the effect of age on outcomes in patients treated for unruptured cerebral aneurysm.
We evaluated anthropometric measures , subjective and objective sleepiness , polysomnography , Homeostatic Model Assessment for IR ( HOMA-IR ) and age-adjusted IGF-1 score.
We evaluated antibodies at repeated time-points among individuals living in an endemic region in Nigeria over almost one year against these vaccine candidates.
We evaluated any major adverse cardiac and cerebral events ( MACCE ) at 12-month follow-up.
We evaluated a potential association between FOXO1 gene locus and the response to AChEI treatment in patients with sporadic AD.
We evaluated associations between alcohol use categories and advanced hepatic fibrosis , by HIV and chronic HCV status.
We evaluated associations between genotypes and rate of change in cognitive function as well as AD-related pathology.
We evaluated associations of age and nutritional variables with natural-killer cell activity , neutrophilphagocytic activity , and neutrophil-sterilizing activity.
We evaluated associations of urine PIIINP with CKD progression and incident ESRD.
We evaluated BLLs in relation to cognition in the continuous National Health and Nutrition Examination Survey ( NHANES ) .
We evaluated brain morphological changes in patients with OSA and their relationship to neuropsychological and oximetric data.
We evaluated cerebellar subregional metabolic alterations in patients with cerebellar ataxia , a representative disease involving the spinocerebellum.
We evaluated CR1 ( rs6656401 ) , CLU ( rs11136000 ) , and PICALM ( rs7110631 ) in @number@ subjects.
We evaluated EGGs by spectral analysis and nonlinear analysis.
We evaluated energy balance , measured renal functions , performed glucose and insulin tolerance tests , and used ramipril to inhibit the angiotensin-converting enzyme.
We evaluated health attitudes in relation to other health markers and to mortality.
We evaluated how internal resources changed over time , and how these trajectories were associated with well-being at T2 using multivariable linear regressions.
We evaluated in a large French cohort of older persons the associations between dietary B vitamins and long-term incident dementia.
We evaluated inflammatory markers as mediators of the relationship between sleep duration and mortality in community-dwelling older adults.
We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid , eicosapentaenoic acid , docosahexaenoic acid , and docosapentaenoic acid.
We evaluated leukocyte telomere length ( LTL ) , a marker of cellular aging , in HIV-infected and uninfected adults.
We evaluated LTFU after the 22nd birthday for HIV-infected youth engaged in care.
We evaluated mice with and without kalirin reduction during tasks measuring psychosis-associated behaviors and spatial memory.
We evaluated mucosal restoration using Rhinoscopy Sum Score and quality of life using Nasal Six Items Symptom Questionnaire.
We evaluated neuroprotective mechanism through in vitro primary cortical neuron ( PCN ) cultures.
We evaluated @number@ dyads since implementation in @date@ .
We evaluated @number@ fresh-frozen cadaveric wrists and recorded the SL gap and SL angle.
We evaluated @number@ individuals recruited from the Italian Longitudinal Study on Aging , a population-based sample of @number@ subjects , aged 65-84 years old.
We evaluated @number@ participants in the National Health and Nutrition Examination Survey ( 1999-2002 ) .
We evaluated @number@ patients at T0 and @number@ at T1.
We evaluated @number@ patients with mild AD and @number@ age- and gender-matched healthy controls.
We evaluated our results regarding true positive , false positive , false negative , precision , recall , false positive rate and F1 score metrics.
We evaluated performance over the first @number@ years of HVBP.
We evaluated predictors of SDD decision by a logistic regression analysis.
We evaluated psychotropic medication use ( antidepressant , antipsychotic , anxiolytic , sedative , or hypnotic ) in participants aged @number@ years or older.
We evaluated racial / ethnic differences in dementia and potential explanatory factors among older diabetic patients.
We evaluated sensibility of the hand in @number@ surgeons aged between @number@ and @number@ years who perform microsurgical operations , thereby undergoing regular tactile training.
We evaluated SIRT6 expression and the effect of incretin-based therapies in carotid plaques of asymptomatic diabetic and nondiabetic patients.
We evaluated skin aging by the validated skin aging score SCINEXA™.
We evaluated the ability of these risk scores to classify participants for MCI risk.
We evaluated the acceptability of and levels of satisfaction with this intervention in the older people who participated in the trial.
We evaluated the age dependence of the optical-reflection characteristics of the surface and subsurface facial skin layers of three age groups.
We evaluated the age of patients over a period of @number@ years and estimated their glomerular filtration rate.
We evaluated the association between BMI and mortality in institutionalized elderly.
We evaluated the association between CVRF and WMLs in a cohort study and determined the blood pressure variables that could predict WML severity.
We evaluated the association between discrimination and leukocyte telomere length ( LTL ; a biological marker of systemic aging ) .
We evaluated the association of age with clinical presentation , serotype and outcomes among healthy and well-functioning patients hospitalized for bacteremic pneumococcal community-acquired pneumonia.
We evaluated the association of cognitive function and age with driving errors.
We evaluated the association of depressive symptoms and telomere length to mortality and recurrence / progression in @number@ patients with bladder cancer.
We evaluated the association of MetS with functional ability in an older population.
We evaluated the association of vestibular symptoms with vestibular findings in the elderly by posturography and video-oculography ( VOG ) .
We evaluated the association of VitD insufficiency with cognitive function in older , community-dwelling adults living in a temperate climate with year-round sunshine.
We evaluated the consistency of the two questionnaires with sex hormone levels.
We evaluated the contributions of various polyglutamine ( polyQ ) disease genes to Parkinson's disease ( PD ) .
We evaluated the cost and health impacts of maternal GBS vaccination in South Africa.
We evaluated the cost-effectiveness of using buccal swab brushes in comparison with blood samples for obtaining DNA for large epidemiological studies of the elderly population.
We evaluated the CSF tau ratio and the MP atrophy as a combined marker for early identification of PSP.
We evaluated the effectiveness of the Salud y Bienestar program to deliver diabetes education in the Hispanic population in the United States.
We evaluated the effect modification by baseline body mass index ( BMI ) .
We evaluated the effect of statins in @number@ Chinese patients with ACS aged ≥ @number@ years with low LDL-C undergoing PCI.
We evaluated the effect of treating keratinocytes with triolein on IL-6 expression and ROS generation in keratinocytes , and MMP1 expression in fibroblasts.
We evaluated the effect on ED use of a high-intensity telemedicine program that provides acute illness care for senior living community ( SLC ) residents.
We evaluated the effects and care costs of a specialized geriatric rehabilitation program aimed at preventing functional decline among at-risk hospitalized elderly.
We evaluated the effects of the structure of mortality on the cohort of long-lived subjects in the second period.
We evaluated the efficacy of Ovoderm on skin biophysical parameters related to cutaneous aging such as elasticity , hydration , and pigmentation.
We evaluated the expression of the androgen receptor ( AR ) to determine its significance in breast cancer.
We evaluated the full field electroretinogram ( ERG ) to assess age-related changes in retina function in humans.
We evaluated the genetic contribution to life span using historical data from three Alpine communities in South Tyrol , Italy.
We evaluated the human plasma proteome in healthy neonates , children and adults using the 2D-DIGE approach.
We evaluated the impact of a \ "Wake-up and Breathe Protocol \ " at our local ICU on sedation and delirium.
We evaluated the impact of cervical disc degeneration on the ICR using a scoring system based on plain radiographs.
We evaluated the infarct volume , as well as neurological and motor function , @number@ h after ischemic brain injury.
We evaluated the influence of age and cholesterol level of the blood clots on sonothrombolysis in an in vitro model.
We evaluated the influence of age and sex on the relationship between central and peripheral vasodilatory capacity.
We evaluated the influence of genetic variation in the oxidative stress pathway on the association between long-term BC exposure and lung function decline.
We evaluated the interrelationships of PA and body composition at the outset and over longitudinal follow-up to changes in older men.
We evaluated the near visual acuity of @number@ dentists and its improvement by using different magnification devices.
We evaluated the normal sensibility of the hand in @number@ patients using static and moving two-point discrimination ( 2PD ) tests and the test.
We evaluated the olfaction of study participants with the Brief Smell Identification Test ( BSIT ) in 1999-2000.
We evaluated the performance of adiposity indicators of MS prediction in the elderly.
We evaluated the prevalence of ECG abnormalities and associations with mortality among childhood cancer survivors.
We evaluated the quality of the identified literature and performed meta-analysis on the included studies using the Rveman5.
We evaluated the reasons for not implementing guidelines for type @number@ diabetes mellitus ( DM ) in patients admitted to a post-acute geriatric ward.
We evaluated the relationship between eNO and lung function by minimizing the effects of aging and height.
We evaluated the reliability and validity of a self-rated analogue scale of global SA in an elderly Singaporean population.
We evaluated the role of aging in human lung EC barrier regulation utilizing a cellular model of replicative senescence.
We evaluated the role of cognitive and brain reserve markers in modifying the risk of postoperative delirium associated with a pathophysiologic marker.
We evaluated the role of conventional cardiovascular risk factors in this process and studied the modifying effect of gender in a population of young adults.
We evaluated the therapeutic effects of human adipose tissue-derived stem cells ( ASCs ) in an animal model of ALS.
We evaluated the type I error rate and statistical power of the proposed hypothesis testing procedures under various scenarios using simulated datasets.
We evaluated the visualizations through focus groups with older adults and identified recommendations to guide the future development of visualizations.
We evaluated this algorithm using @number@ days of data collected in the homes of @number@ elderly community-dwelling elders.
We evaluated trends in diverticular disease and associated factors over @number@ years.
We evaluated weight change in the first year after ART initiation and its association with subsequent mortality.
We evaluated whether chronic low-calorie sweetener use is a risk factor for abdominal obesity.
We evaluated whether control beliefs are associated with risk for 4-year mortality , after accounting for established \ "classic \ " biomedical risk factors.
We evaluated whether dietary supplementation with Lactobacillus delbrueckii subsp. bulgaricus @number@ could enhance the immune response in the elderly.
We evaluated whether health indicators and proxies for market integration were associated with VO2 max levels and rate of decline for the Tsimane.
We evaluated whether lower blood DNA methylation in heavily methylated repetitive sequences predicts the risk of ischemic heart disease and stroke.
We evaluated whether or not treatment with DMAb influenced progression of aortic calcification ( AC ) and incidence of cardiovascular ( CV ) adverse events.
We evaluated whether serum AG might be predictive of elderly mortality in a community-based cohort in Korea.
We evaluated whether strongly lateralized connections covaried within the same individuals.
We evaluated whether varying the kyphosis angle criterion would change the prevalence estimate.
We evaluated whether vascular remodeling is present in physiological aging and whether hypertension accelerates the aging process for vascular function and structure.
We evaluated which neuropsychological measures in our cognitive battery are most strongly associated with cerebrospinal fluid ( CSF ) biomarkers of AD brain pathology.
We evaluate our approach with both test-retest data and with application to a driving biological problem.
We evaluate the accuracy of self-reported HIV status , which may provide useful information for targeting interventions or offer an alternative to biomarker testing.
We evaluate the different mechanisms that could maintain dynamic stress granules.
We evaluate the expression features of disease related genes and find that different diseases related genes show different expression perturbation sensitivities in various conditions.
We evaluate the implications of these findings in sirtuin inhibition-based cancer treatment and in the application of sirtuin activation for anti-aging therapy.
We evaluate those associations using the Survey on Assets and Health Dynamics among the Oldest Old ( AHEAD ) .
We examine age differences in risk-taking behaviors in multiple risk domains across the adult life span.
We examine a novel device that employs bipolar radiofrequency ( RF ) , intense pulsed light ( IPL ) , and infrared diode laser.
We examine cause-specific mortality ( cardiovascular and cancer ) by baseline disease status.
We examine CE-MS from an application point of view , and evaluate its merits and vices for biomarker discovery and clinical applications.
We examine competing hypotheses regarding the role of age in explaining women's job placement and starting wages.
We examined 6- to 24-week-old ob / ob and 6- to 10-week-old normal mice.
We examined a behavioral mechanism of how increases in leg strength improve healthy old adults ' gait speed.
We examined a case series of postmortem brains from U.S. military veterans exposed to blast and / or concussive injury.
We examined activities of polyol pathway enzymes , G6PD and glutathione system in lenses from subjects suffering from cataract due to aging and diabetes.
We examined adolescents ' reasons for tanning and how these relate to appearance evaluation and orientation.
We examined age- and expertise-related differences in the bilateral deficit in force initiation.
We examined Age × Cohort interactions in mixed-effects models with / without controlling for education effects.
We examined age differences in the effectiveness of multiple repetitions and providing associative facts on tune memory.
We examined all ASXL1 truncating variants in the ExAC database and determined most are likely somatic.
We examined a novel method , individualized tailored calendars , to accurately ascertain falls in older adults.
We examined a number of biological and social determinants that influence these factors.
We examined a range of molecular measures related to vascular function in matched premenopausal and postmenopausal women before and after @number@ wk of exercise training.
We examined a rural Ghanaian population with a high pathogen exposure for selective advantages of APOE-ε4 , to survival and or fertility.
We examined associations between causes of intentional and unintentional weight loss and weight gain and mortality.
We examined associations between membership in alcohol use and VACS index trajectories using multinomial regression.
We examined associations between place of death and sociodemographic factors , social support , and residential and health care system factors.
We examined associations between plasma phospholipid n-3 and n-6 PUFAs with risk of incident mobility disability and gait speed decline.
We examined associations of BMI with healthy and chronic disease-free life expectancy in four European cohort studies.
We examine data showing that elderly-derived innate cells are highly immunosuppressive and may provide a more tumorigenic milieu than their younger counterparts.
We examined baseline and new-onset diabetes and cognitive decline with joint longitudinal-survival models to account for death.
We examined both horizontal and vertical saccades in @number@ healthy elderly , @number@ aMCI , and @number@ AD.
We examined both levels of knowledge and factors associated with an overall knowledge score.
We examined both the whole population recruited , and a sub-population screened so as to exclude visual problems.
We examined cardiac fuel metabolism in the diabetics as compared to non-diabetics who underwent cardiac catheterization for heart diseases.
We examined change in six QOL domains from @number@ to @number@ using random coefficient models.
We examined changes in beta oscillations during rest and movement in primary motor cortex ( M1 ) .
We examined changes in protein levels of molecular modulators of growth and differentiation in young vs. old , human and mouse skeletal muscle.
We examined cognitive stability and change from childhood to old age in both cohorts , and within old age in the LBC1921.
We examined component vascular risk factors of MetS as correlates of different cognitive domains.
We examined correlates of newly screened depression and new antidepressant use among participants not depressed or not using antidepressants in the previous study wave.
We examined CWS in young ( n = 18 ) and older ( n = 18 ) adults for both overground and treadmill walking.
We examined data from @number@ Japanese adults.
We examined data from @number@ nondemented participants from the Swedish Adoption / Twin Study of Aging.
We examined development of squamous cell carcinoma in a telomerase deficient murine background with long and short telomeres.
We examined distributions of carotid atherosclerosis and arterial stiffness in a socioeconomically diverse , biracial , urban sample.
We examined effect modification by age in the relationship between eGFR and gait speed.
We examined effect modification by statin use , obesity , and diabetes.
We examined effects across two levels of spatial scale : the census tract and block group.
We examined end-of-life treatment preferences and days of desired life for several health scenarios among male inmates incarcerated primarily for murder.
We examined experiences and concerns among caregivers of community-dwelling people with dementia from two ethnic groups.
We examined extracts from human amygdala ( snap-frozen at autopsy ) to investigate whether novel and as yet uncharacterized misfolded proteins would be detectable.
We examined factors associated with support using multilevel models.
We examined filial concepts across five cultural groups : African- , Asian- , Euro- , Latino- , and Native Americans.
We examined fMRI data of @number@ healthy female participants ( 11 30 years old ) performing a relational reasoning paradigm.
We examined for any significant differences and the correlation of skin aging parameters with age and two different sites.
We examined frailty prevalence in China by sociodemographics and geographic region , and investigated correlates of frailty.
We examined herein the molecular signaling events responsible for osteocyte apoptosis and osteoclast recruitment triggered by aging and Cx43 deficiency.
We examined how AGE accumulation affects assisted reproductive technology ( ART ) outcomes.
We examined how different survey- and register-based measures of depression were associated with 7-year mortality in a cohort of middle-aged Danish men.
We examined how enrichment strategies affected each component of the model.
We examined how social desirability , mood congruency and framing influence the mood-MSE relationship.
We examined how subjective perceptions of these costs varied with age and influenced task engagement.
We examined if obesity modifies the clinical presentation , LV morphology , outflow hemodynamics , and exercise tolerance in HC.
We examined if unitization inherent preexperimentally could reduce the associative deficit in older adults.
We examined infants ' perception of the intonational characteristics of yes-no questions and declarative sentences in English.
We examined insurance regain among youth with no , nonsevere , and severe disabilities between the ages of @number@ and @number@ using a longitudinal design.
We examined interactions among blood pressure ( BP ) , internal carotid artery ( ICA ) flow velocity parameters , and WMH.
We examined intermediate-term associations between primary and secondary air pollutants and mean methylation and methylation at each position with distributed-lag models.
We examined in vitro whether TNFα or IL-1β impaired morphology and motility of growth cones in spinal cord neuron cultures.
We examined life expectancies with cognitive impairment ( CILE ) and free of cognitive impairment ( CIFLE ) in seven developing LAC countries.
We examined longitudinal changes in CMR-derived aortic stiffness in children and young adults with CTDs.
We examined major lifetime unfair treatment and everyday discrimination.
We examined mechanisms behind this dissociation in an fMRI study , using a selective attention task in which relevant and irrelevant information appeared simultaneously.
We examined mitochondrial function in the amyloid-β protein precursor transgenic ' TgCRND8 ' mouse model of AD.
We examined mortality risks in the @number@ largest immigrant groups in Sweden between @number@ and @number@ using Cox regression.
We examined multimodal biomarker correlates of the consecutive series of the first @number@ Alzheimer's Disease Neuroimaging Initiative autopsies.
We examined multimorbidity prevalence as the presence of at least two physical chronic conditions , or as combined physical-mental health multimorbidity.
We examined multiple brain markers associated with age-related variation in cognition.
We examined multiple exposure windows ( 1-6 months ) before DNA methylation measurement.
We examined muscle sympathetic nerve activity ( MSNA ) and plasma catecholamine concentrations in healthy young and aged individuals during whole-body passive heat stress.
We examined nine-year trends in tuberculosis ( TB ) incidence patterns for the entire population of Michigan , and within demographic subgroups.
We examined @number@ consecutively autopsied patients ( @number@ FTLD-TDP and @number@ ALS patients ) and @number@ normal controls.
We examined @number@ elderly patients with ischemic heart disease , including @number@ patients of Korean nationality and @number@ patients of Slavic ethnicity.
We examined @number@ failed cardiac allografts to identify the etiology of graft failure.
We examined @number@ Japanese AD patients with positive family histories , and @number@ sporadic patients with early onset ( < 60-year-old ) .
We examined @number@ lung cancer patients undergoing surgery who received antithrombotic therapy for cardiovascular complications.
We examined @number@ men aged 40-75 years.
We examined @number@ men aged 65-88 years and assessed total serum T concentrations.
We examined @number@ mtSNPs using the PCR-Luminex method , with a success rate of @percent@.
We examined @number@ @number@ participants enrolled in HRS and @number@ enrolled in ELSA in @number@
We examined @number@ paired patient-proxy follow-up interviews.
We examined @number@ participants aged ≥50 years from a subsample of the Mexican Health and Aging Study.
We examined @number@ subjects including six patients ( i.e. , four with MND / LMN and two with PMA ) and @number@ COs.
We examined @number@ subjects ( @percent@ women ) aged 59-96 years.
We examined odds of having each complication , after adjusting for clinical differences between younger- and older-onset T2DM.
We examined our institution's experience with running a designated emergency theatre for acute surgical patients.
We examined perceptions of health needs of the elderly across local stakeholders in an urbanizing rural area.
We examined polymorphisms in the genes ACE and IDE in relation to cognitive phenotype.
We examined post mortem human retinas for the localization of a biomarker of lipid peroxidation ( 4-hydroxy 2-nonenal , 4-HNE ) by immunohistochemistry.
We examined potential risk factors for changes in objectively assessed sleep duration within a large sample of community-dwelling older men.
We examined prescriptions filled for LABDs with or without ICSs ( LABDs±ICSs ) within @number@ days prior to and @number@ days after hospitalization.
We examined primary outcomes of satisfaction with treatment decision-making and treatment regret by ethnic-language group.
We examined quadratic relations of cholesterol to performance on a comprehensive neuropsychological battery.
We examined racial differences in the cross-sectional association of education with physical and cognitive function performance in older adults.
We examined relationship between NRC in SNc and clinical parameters.
We examined reports of any mistreatment ( verbal , financial , or physical ) and multiple types of mistreatment.
We examined ( R , R' ) -MNF's effect on glycolysis in PANC-1 cells and tumors.
We examined secular trends and age , period , and cohort effects in mortality from AMI in China from @number@ to @number@
We examined serial position effects in word-list recall for MCI participants compared to Alzheimer patients and controls.
We examined several vascular factors in relation to the rates of decline in @number@ cognitive domains in a population-based cohort.
We examined sleep dysfunction across the cognitive spectrum in ET.
We examined SOCE in human PASMCs exposed to hypoxia and pulmonary arterial pressure in mice using the isolated perfused / ventilated lung method.
We examined social support as a facilitator of advance care planning in unmarried women of different sexual orientations.
We examined telomeres / telomerase in cultured cells from > @number@ mammalian species to place different uses of telomeres in a broad mammalian context.
We examined temporal trends in death rates from colorectal cancer in Chile from @number@ to @number@
We examined the ability of people @number@ to @number@ years old to apply global , configural , and featural face-processing strategies.
We examined the action of key neurotransmitters : purinergic and muscarinic agonists on ATP release and its paracrine effect.
We examined the AE profiles associated with polypharmacy and aging using the Japanese Adverse Drug Event Report ( JADER ) database.
We examined the anti-inflammatory effects of Ginkgo biloba extract ( EGb ) in interleukin-1 ( IL-1 ) -stimulated human chondrocytes.
We examined the antimicrobial activity of N12D and N23D against drug-resistant Staphylococcus aureus.
We examined the antiobesity and antioxidant effects of supplementation with doenjang , a fermented soybean paste , in overweight Koreans with the PPAR-γ2 C1431T polymorphism.
We examined the antioxidant and antiaging effects of the extract and fractions of P. tarminiana fruits.
We examined the association between 20-year weight change and cognitive function in late life.
We examined the association between consistent FKP and risk of TKR using multiple binomial regression with generalized estimating equations.
We examined the association between fibre intake and risk of knee OA.
We examined the association between inflammation , PVS , and WMH in the Lothian Birth Cohort @number@ ( N = 634 ) .
We examined the association between leukocyte telomere length and variations in the association by race or type of discrimination.
We examined the association between literacy and risk of likely dementia in older adults.
We examined the association between physical activity and healthy ageing over @number@ years of follow-up.
We examined the association between selected inflammation gene polymorphisms and CRC risk.
We examined the association between serum antioxidant status and MetS.
We examined the association between serum leptin levels and AMD.
We examined the association between telomere length and prenatal tobacco exposure ( PTE ) in @number@ children aged @number@ to @number@ years.
We examined the association between the VACS Index and HIV-associated neurocognitive impairment ( NCI ) .
We examined the association between trajectories of the Framingham general cardiovascular disease risk score ( FRS ) over midlife and motor function later in life.
We examined the association of age with symptom burden.
We examined the association of alcohol intake with these imaging markers using regression models adjusted for demographic , clinical , and vascular risk factors.
We examined the association of circulating levels of vitamin C and E with incident whole knee radiographic OA ( WKROA ) .
We examined the association of cognitive reserve-related factors over the lifespan with the risk of dementia in a community-based cohort of older adults.
We examined the association of coronary artery and abdominal aortic calcified plaque ( CAC and AAC , respectively ) with cognitive functioning in middle-aged adults.
We examined the association of F & V intakes and bone mineral status in Chinese elderly adults and explored the potential mechanisms.
We examined the association of increasing adherence to MeDi with presence of infarcts on MRI.
We examined the association of individual- and community-level social capital with suicidal ideation after adjusting for social support among older adults living in the community.
We examined the association of insomnia and CBI.
We examined the association of risk of disease , functioning and engagement with society at baseline with confidence and continued engagement at follow-up.
We examined the association of these cognitive assessments with both the connectivity of the whole brain network and individual cortical regions.
We examined the association of TMEM106B variants with a semiquantitative measure of TDP-43 pathology in a series of regression analysis.
We examined the associations among age , cardiorespiratory fitness and carotid arterial wall viscosity.
We examined the associations between dietary exposures and AF with Cox proportional hazards regression.
We examined the associations between frailty and inflammatory markers , in particular neutrophil lymphocyte ratio ( NLR ) , in elderly cancer patients.
We examined the associations of midlife kOA with body mass index ( BMI ) and activity exposure across adult life and their interaction.
We examined the associations of @number@ LOAD risk loci , individually and collectively as a genetic risk score , with cognitive function.
We examined the attentional demands of walking to two types of cues using a probe reaction time ( RT ) task.
We examined the attitude of postmenopausal women toward menopause and aging with respect to sociodemographic variables and postmenopausal years.
We examined the behavioural and biological characteristics of healthy obese adults that progressed to an unhealthy state over @number@ years follow-up.
We examined the clinicopathological and cytological features of seven cases of MASC defined by RT-PCR analysis of the ETV6-NTRK3 fusion gene.
We examined the concentration and cellular compartmentalization of selenium in the temporal cortex of Alzheimer's disease and control brain tissue.
We examined the context of intergenerational support exchanges with aging parents and its association with middle-aged couples ' marital satisfaction.
We examined the contribution of age , body composition , and putative genetic sources to the interindividual variation of sRAGE.
We examined the cross-sectional association of PTSD with TL in women exposed to traumas common in civilian life.
We examined the cross-sectional relationship between cerebrovascular hemodynamics and white matter structural integrity in elderly individuals with vascular risk factors.
We examined the directionality of relations between depressive symptoms and perceptual speed using bivariate dual change score models.
We examined the directional relations between CRP and symptoms of depression among older adults.
We examined the distribution of variable number of tandem repeats ( VNTRs ) and conducted polymorphic analysis of the entire region of SLC6A3.
We examined the effect of a task-irrelevant dimension on response times in young adults and seniors.
We examined the effect of changing age and race / ethnicity distributions on total smoking prevalence from @number@ to @number@
We examined the effect of cognitive fatigue on the Attention Networks Test ( ANT ) .
We examined the effect of high frequency tactile stimulation ( tHFS ) on tactile and motor performance as well as tactile-motor interactions.
We examined the effect of HSOA on hospitalization and emergency department ( ED ) treatment , and estimated the potential cost savings.
We examined the effects of aging and cognitive fatigue on working memory ( WM ) related brain activation using functional magnetic resonance imaging.
We examined the effects of lower extremity power training and detraining on old adults ' gait kinetics.
We examined the effects of lower-extremity power training on neuromuscular activation during level gait in old adults.
We examined the effects of plasma levels , intake and supplementation of vitamin C , vitamin E , and β-carotene on tHcy.
We examined the effects of T0901317 , a potent LXR agonist , on angiogenesis of human umbilical vein endothelial cells ( HUVECs ) .
We examined the end-effector kinematics of @number@ young and @number@ elderly participants in the multi-step activity of daily living of tea-making.
We examined the expression levels of glucose transporters in the kidney.
We examined the extent to which it contributes to differences in non-pathological cognitive ability in old age , after adjusting for childhood mental ability.
We examined the extent to which we mitigated community-defined timeliness risk factors for delayed follow-up , with a focus on Spanish-speaking participants.
We examined the fate of ductal plate cells in the hilar region of the liver.
We examined the fate of these receptors in cases of AD as well as in aging PS2APP mice a proposed model of the disease.
We examined the function of ARF6 in the kidney podocyte because Rac1 was implicated in kidney diseases involving this cell.
We examined the genetic relationship between AD and various cancer types using GWAS summary statistics from the IGAP and GAME-ON consortia.
We examined the impact of age on sexual and urinary function and bother during the first @number@ years after radical prostatectomy.
We examined the impact on ratings of speaker and rater characteristics , as well as the interaction of these characteristics with the dimension being rated.
We examined the individual association between body mass index ( BMI ) and sleep quality among the very elderly.
We examined the influence of age on associations between affective states , social support , and alcohol use by age cohorts.
We examined the influence of TOMM40 \ "523 \ " polymorphism on spatial navigation and its brain structural correlates.
We examined their gaze behavior during obstacle avoidance in singletask ( ST ) and dual-task ( DT ) conditions.
We examined the item characteristics , the factor structure , and the concurrent validity of a trait measure of psychobiosocial states.
We examined the longitudinal association between TV viewing , physical activity and inflammatory markers over a 4-year follow-up period.
We examined the longitudinal associations between diabetes , indicators of glucose metabolism and depressive symptoms over @number@ years of follow-up.
We examined the long-term weight trajectory of childbearing women relative to weight progression that could be expected in the absence of pregnancy.
We examined the metabolism and protein composition of sdLDL and lbLDL in six subjects with combined hyperlipidemia on placebo and rosuvastatin @number@ mg / day.
We examined the perceptions that older adults living with HIV have about protecting and improving brain health and cognition through lifestyle behaviors.
We examined the performance of commonly used mediation testing methods for the indirect effect in genome-wide mediation studies.
We examined the pitch reflex in AD patients ( n = @number@ ) compared to an age-matched control group ( n = @number@ ) .
We examined the postmortem neuropathology and clinical records of @number@ sequentially encountered cases of human narcolepsy.
We examined the prevalence of anemia among elderly and sought a relationship between hemoglobin and the phenotype of frailty.
We examined the prevalence of self-reported traumatic brain injury ( TBI ) in a demographically diverse sample.
We examined the prevalence of third molars and associated pathology and used the chi-squared test to perform the statistical analysis.
We examined the prevalence of thrombocytopenia and determinants of platelet count in a healthy population with a wide age range.
We examined the prevalence rate of OA by occupational cluster.
We examined the pupil response during listening : the peak amplitude , the peak latency , the mean dilation , and the pupil response duration.
We examined the relation between parental longevity and cognition and subclinical markers of brain ageing in community-dwelling adult offspring.
We examined the relation between WMH location and cognition in a memory clinic cohort of patients with sporadic SVD.
We examined the relationship between alcohol use and HIV disease severity patterns using joint trajectory modeling.
We examined the relationship between ALM and mortality among prefrail and frail older adults.
We examined the relationship between plasma homocysteine and cognitive decline in an older hypertensive population.
We examined the relationship between risk-standardized readmission rates and hospital-level composite measures of quality and mortality.
We examined the relationship between the Five-Factor Model of personality and the experience and overall usage of autobiographical memory in two studies.
We examined the relationship of apathy with neurocognitive performance , age , disease markers , and functional disability in @number@ HIV-infected individuals.
We examined the relationship of retinal microvascular signs with both prevalent and incident end-stage renal disease ( ESRD ) in a multi-ethnic Asian population.
We examined the risk factors for serious infections in biologics-treated elderly RA patients.
We examined the role of indigenous microbes in early humans as fundamental contributors to this age structure.
We examined the role of self-relevance in older and younger adults ' evaluations of remembered events.
We examined the roles of these receptors in larval zebrafish in vivo by assessing the impact of translational gene knockdown on cardiac function.
We examined these associations in pre- , peri- and postmenopausal women without known cardiovascular disease.
We examined these outcomes in patients managed with renal supportive care without dialysis ( RSC-NFD ) and those planned for or commencing dialysis.
We examined these relationships in the brains of @number@ healthy young adults.
We examined the sex discrepancies in cognition using a comprehensive neuropsychological battery.
We examined the suitability of total tissue samples of human sclera for the estimation of age at death.
We examined the temporal relationship between serum levels of inflammatory biomarkers and persistence of depressive symptoms among older participants.
We examined the time course of sarcopenia and determinants of transitioning toward and away from sarcopenia.
We examined the trends in the C. difficile-associated fatality rate , hospital length of stay , and hospital charges over the last decade.
We examined the variability of popular food items in @number@ fast-food restaurants in the United States by portion size during the past @number@ years.
We examined the volunteer service contribution of older adults ( N = @number@ ) to volunteer role development and agency attachment.
We examined this cross-linguistic difference , firstly , through a reanalysis of the Italian and Spanish reading latencies.
We examined this idea using multivoxel pattern classification of fMRI data to measure category representations while participants saw and remembered pictures of objects and scenes.
We examined this issue in a large sample of right-handed healthy young adults.
We examined this relationship in older people with diabetes and compared the results to those currently used in clinical practice.
We examined this type of memory error in healthy older adults.
We examined time trends in the prevalence of cirrhosis and its related complications , such as hepatic decompensation and hepatocellular carcinoma ( HCC ) .
We examined treatment effects on class membership and compared classes on baseline individual differences and 6-month abstinence rates.
We examined trends and subject characteristics associated with oxygen therapy use from 2001-2010 in the United States.
We examined turning bias in @number@ right-handed healthy adults ( 18-77 years old ) , who navigated a virtual Morris Water Maze.
We examined whether adherence to a Mediterranean-style diet has positive effects on mobility assessed over a 9-year follow-up in a representative sample of older adults.
We examined whether angiogenic factors during pregnancy also affect childhood retinal microvasculature in a population-based prospective cohort study among @number@ mothers and their children.
We examined whether a perceptual-learning task could be used to improve age-related declines in contrast sensitivity.
We examined whether CANTAB tests measured specific cognitive functions , using established neuropsychological tests as a reference point.
We examined whether clinical findings or serum IgG antibody titers to periodontal bacteria are risk factors for the development of periodontitis recurrence.
We examined whether cognitive reserve ( CR ) modifies this association.
We examined whether cortical acetylcholine esterase ( AChE ) activity is reduced at this stage and correlated with cognitive function.
We examined whether country-level differences in the perceived status of older adults moderated the effect of age identification on subjective ill-health.
We examined whether CSA is associated with the ALDH2 2 genotype in Japanese.
We examined whether cumulative average and longitudinal changes in these biomarkers were associated with subsequent MI risk.
We examined whether early-life educational quality and literacy in later life help explain these disparities.
We examined whether food insecurity is associated with prevalent CKD among lower-income individuals in both the general US adult population and an urban population.
We examined whether glucose can help older adults preserve their positivity effect ( PE ) under high cognitive load.
We examined whether hip fracture patients who develop postoperative delirium have altered levels of inflammatory mediators in cerebrospinal fluid ( CSF ) prior to surgery.
We examined whether leukocyte telomere length was associated with menopausal age.
We examined whether levels of serum 25 ( OH ) D are associated with objective measures of sleep in older men.
We examined whether long-term fluid cognitive decline was associated with memory problems in everyday life , and whether stress plays a moderating role.
We examined whether low incidence of specific cancers is a mechanism for familial clustering of longevity.
We examined whether metabolic dysregulation predicted the 2-year course of clinical depression.
We examined whether mind-wandering frequency may be related to falls-a major health-care problem.
We examined whether normal aging spares or compromises cue-driven spontaneous retrieval processes that support prospective remembering.
We examined whether @number@ young adults ( 18-30 years ) and @number@ older adults ( 50-80 years ) could voluntarily inhibit overflow.
We examined whether objectively recorded ELS and retrospectively self-reported traumatic experiences across the lifespan are associated with LTL in later adulthood.
We examined whether older adults also show greater conceptually based implicit priming from distracting information.
We examined whether or not baPWV is an independent risk marker of subsequent CD in a population of older Japanese.
We examined whether or not the USCT changes its histological architecture by vaginal delivery in correlation with the levels @number@ and @number@ supportive tissues.
We examined whether Pb levels would be associated with altered diurnal cortisol profile , as a primary mediator of AL , during aging.
We examined whether piRNAs are expressed differently between AD cases and controls and explored the potential regulatory effects of risk SNPs on piRNA expression levels.
We examined whether serum adiponectin concentration is associated with all-cause and cardiovascular mortality in elderly Asians.
We examined whether social priming of cognitive states affects the inhibitory process in elderly adults , as aging is related to deficits in inhibitory control.
We examined whether sociodemographic factors and smoking intensity were associated with purchasing cigarettes from cheaper sources using the general estimating equations model.
We examined whether structural integrity of cerebral gray and white matter ( WM ) mediated the relationship between pain and mobility in community-dwelling older adults.
We examined whether the association between depressive symptoms and physical performance measured using gait speed is bidirectional.
We examined whether there is an acute increased risk of falls in the days following a change to an antipsychotic or benzodiazepine drug prescription.
We examined whether these EEG measures , relative to age- and sex-matched controls , differed between diabetic participants with and without early SH.
We examined whether these factors attenuated race-related differences in late-life cognition.
We examined whether this dysfunction persists in adulthood , and how brain activity in the mirror neuron system relates to social functioning outside the laboratory.
We examined whether undiagnosed cognitive impairment in T2DM-patients is associated with a reduced health status and depressive symptoms.
We examined whether women who had regular jobs throughout life performed better cognitively than older adult housewives.
We examined why this occurs.
We examine each perspective's predictions using data from the first wave of Midlife in the United States ( 1995-1996 ; MIDUS ) .
We examine educational gradients in depression and identify underlying mechanisms of how education might affect depression.
We examine goal-directed behavior in T. gondii IgG positive and negative elderly subjects in auditory distraction paradigm.
We examine gray matter alterations by grouping brain regions into anatomical lobes as well as functional zones.
We examine in depth the quality of data from a random selection of studies , from an epidemiological and statistical point of view.
We examine normal aging from the perspective of topological patterns of structural brain networks constructed from two healthy age cohorts @number@ years apart.
We examine obesity , intentional weight loss and physical disability in older adults.
We examine several methodological considerations when eliciting probabilistic expectations in a developing country context using the Longitudinal Ageing Study in India ( LASI ) .
We examine survival by insurance type for patients with AML.
We examine the age structure of early humans with models that reveal an extraordinary balance of human fertility and mortality.
We examine the association between handrail use to climb stairs at increasing ages , and long term survival.
We examine the capacity for older adults living in the community to live well with or without chronic disease as they age.
We examine the effects of a programme of incentivised depression screening in chronic disease within a UK primary care setting.
We examine the effects of three different measures of the quality of medical care.
We examine the extent to which dual-learning systems mediate auditory and speech learning in younger and older adults.
We examine the impact of different doses of exposure to UV radiation and the subsequent production of oxidative stress in AMD.
We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.
We examine the role of NF-κB activation and its dysregulation and how NF-κB activity differs among subgroups of T cells.
We examine the role of retrieval organization in these effects.
We examine these data in the light of Lopata's concept of ' husband sanctification ' ( @number@ ) .
We examine the types of driving behavior that increase in frequency with age.
We examine to what extent clients of community care in Europe ( n = @number@ ) complete such activities despite their cognitive problems.
We examine whether long-term care ( LTC ) experience helps explain the low demand for long-term care insurance ( LTCI ) .
We examine whether men's testosterone is associated with cognitive performance among Tsimane forager-horticulturalists of Bolivia despite relatively lower levels of testosterone and higher immune burden.
We examine whether nursing home closures are geographically concentrated and related to local community characteristics such as the racial and ethnic population mix and poverty.
We exchanged data with colleagues performing a GWAS in Japanese PD cases.
We excluded all articles lacking of surgical cohort and those with main interest in conservative treatment.
We excluded individuals with moderate and severe carotid stenosis.
We excluded @number@ non-biological stones and @number@ stones , which originated from outside the study zone.
We excluded patients with less than @number@ years ' follow-up , prevalent diagnoses of lung cancer , or incomplete laboratory data.
We excluded studies that did not use @number@ World Health Organization criteria for diabetes.
We excluded those who were diabetic at baseline in the longitudinal analysis.
We exemplify our strategy for shape regression on the Grassmann manifold , but note that the method is generally applicable for time-warped geodesic regression.
We exemplify PosiGene's performance using simulated and real data.
We expanded this observation by large-scale analysis of mRNA expression.
We expand this work to describe systems-level differences in specialization in a healthy adult lifespan sample ( n = @number@ 20-89 y ) .
We expected alcohol use to be similar to previous reports , correlate with higher anxiety and insomnia , and worsen the anxiety-insomnia relationship.
We expected an interesting interplay between internalized age stereotypes and age-related differentiation in beliefs about personality development.
We expected that the association between cognitive decline and everyday memory problems would be magnified in the context of self-reported and physiological stress.
We expect results that demonstrate significant and favorable influence of pretreatment with 5-alpha-reductase inhibitors on certain outcomes.
We expect strongly a therapeutic drug for dementia to be released in the near future.
We expect that receiving instrumental and emotional support reduces loneliness , which in turn preserves cognitive functioning.
We expect that the proposed method will help to elucidate the biological mechanism unrevealed by the existing approaches.
We expect the methods proposed can improve medical care quality and reduce medical resource wastage , while ensuring patient privacy.
We expect these results to be applied to appropriate rehabilitation strategies for hearing-impaired elderly who experience difficulty in communication.
We expect these trends to continue.
We expect this supplement to serve as a catalyst for researchers interested in engaging diverse community-dwelling elders in health-related research.
We experienced that two Japanese women diagnosed with syringoma , confirmed by a punch biopsy , were successfully treated with fractional resurfacing.
We exploit the exogenous variation in years of schooling arising from compulsory schooling reforms implemented in six European countries during the 1950s and 1960s.
We explored changes in finger interaction in the process of healthy aging as a window into neural control strategies of natural movements.
We explored fear of falling and activity restriction in individuals who have experienced fall-based injuries.
We explored generalization capability using k-fold cross-validation and receiver operating characteristic ( ROC ) analysis with variable k.
We explored height , polymorphisms in genes related to growth processes as main effects and their possible interactions.
We explored how adaptation alters the perceived age of faces , a fundamental facial attribute which can uniquely and reliably be scaled by observers.
We explored knowledge , attitudes , and practices associated with the menopause transition particular to women in the multi-ethnic cultural context of Singapore.
We explored new empirical evidence regarding whether social capital was a determinant of psychological distress.
We explored potential pathways by leveraging genetic , brain DNA methylation , miRNA , and transcriptomic data collected from this same group of participants.
We explored social , economic , demographic and clinical correlates of the presence of hypertension , its awareness and control using multiple logistic regression analyses.
We explored thalamic diffusion differences related to white matter lesions ( WMLs ) and their association with cognitive function in middle-aged individuals.
We explored the association between accelerated biological aging and air pollution , a potential mechanism linking air pollution and health.
We explored the components of RVs by immunohistochemistry , using antibodies for GVD markers.
We explored the content of and barriers to discussion about falls.
We explored the correlation between LUTS ( assessed by IPSS ) and ED ( assessed by SHIM ) in men over @number@ years of age.
We explored the effects of NTF4 for future clinical use as a therapeutic to improve function in aging human laryngeal muscles.
We explored the evidence about diabetes care for older people with South Asian ethnicity to understand the contexts and mechanisms behind interventions to reduce inequalities.
We explored the possibility to train such a model on whole-blood DNA methylation and cell counts without the need for purification.
We explored the potential advantages of using an instrumental variable approach in the context of primary androgen deprivation therapy ( ADT ) for prostate cancer.
We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of @number@ AD cases compared with @number@ nondemented elderly.
We explored the relationship among Stroop performance , rs-fcMRI , and CSF Aβ₄₂ levels in cognitively normal older adults.
We explored the relationship between sleep disturbances and mild cognitive impairment ( MCI ) in community-dwelling seniors.
We explored the spectrum of cortical CMIs that can be visualized with @number@ T magnetic resonance imaging ( MRI ) .
We explored the stability and covariation of arthritis pain and depressive symptoms.
We explored the trajectory of TB burden if the DOTS strategy is maintained or if new interventions are introduced using currently available and soon-to-be-available tools.
We explored the window of opportunity hypothesis in relation to cognitive aging and dementia.
We explored this question by examining , as a function of animal age , responsiveness of murine macrophages on the single cell level.
We explored whether adjustments for age and medical conditions were warranted based on differential base rates of spuriously impaired scores.
We explored whether a pattern of these measures exists that predicts stroke and Alzheimer disease ( AD ) risk.
We explored whether inhibiting mPGES-1 in human and mouse models of breast cancer affects tumor-associated immunity.
We explored whether odor orienting responses are impacted throughout both adulthood and normal and pathological aging in mice.
We explored whether olfactory identification is related to in vivo measures of Aβ burden using Pittsburgh Compound B ( PiB ) PET.
We explored whether or not this increased risk persisted in HIV infected and uninfected men when controlling for traditional fragility fracture risk factors.
We explored whether they are influenced by gene variants affecting adenosine metabolism or catecholamine receptors.
We explored whether unemployment in early adulthood is associated with shorter LTL , a potential biomarker of premature aging.
We explore how the abstraction of communication theory as an organising principle for multicellular biology could be realised.
We explore the effects of disability discrimination laws on hiring of older workers.
We explore the role of DNA damage processing in the progression of cognitive decline by creating a new mouse model.
We explore the sensitivity of our approach to on-body placement of the accelerometer by comparing hip , left and right wrist placements.
We explore the specific gaps in understanding longitudinal patient-centered outcomes of CRC treatment.
We explore this potential herein.
We explore this relationship in a large cohort of otherwise healthy subjects.
We explore whether knowledge and expertise accumulated from past decisions can offset cognitive decline to maintain decision quality over the life span.
We exposed AGS , HGC-27 and GES-1 gastric cancer cell lines to IFN-γ and found significantly reduced colony formation ability.
We expressed dichotomous treatment effects as risk ratio ( RR ) with @percent@ confidence intervals and continuous outcomes as mean difference ( MD ) .
We expressed fluorescent tagged-WRN ( eYFP-WRN ) in human @number@ embryonic kidney cells and detected interacting proteins by co-immunoprecipitation from cell extract.
We expressed in the lens a mutant Ub containing a K6W substitution ( K6W-Ub ) .
We expressed RER1 and a C-terminal mutant RER1Δ25 , which lacks the ER retention / retrieval function , in HEK293 and H4 neuroglioma cells.
We expressed wild-type ( wt ) LRRK2 and mutations and evaluated their role during oxidative stress conditions.
We express secretory forms of human Aβ1-40 or Aβ1-42 in Drosophila neurons and observe preferential localization of Aβ1-42 within AEL vesicles.
We extend current understanding of novelty processing in normal aging by comparing this habituation related-hyperfrontality with intellectual functioning.
We extensively searched @number@ Korean and @number@ English online databases , extracting a total of @number@ studies for the analysis.
We extracted a sub-sample of @number@ highly active older adults to be included in the analyses.
We extracted data from included studies and assessed risk of bias using the Cochrane Collaboration risk of bias tool.
We extracted geriatric assessments from the population descriptives or the in- and exclusion criteria.
We extracted @number@ individuals in these studies for our meta-analysis.
We extracted spatial coordinates and inserted them in an electronic database.
We extracted study designs , sample sizes , populations , and probabilities of benefits / harms of the health options.
We extracted the data regarding patient demographics , treatment , and prognosis at the last follow-up for each patient.
We extracted the late onset patients and analyzed them for predictive factors of disability and death , using the Cox proportional model.
We extracted tract-specific diffusion tensor imaging ( DTI ) metrics to assess changes across PPA variants and perform brain-behavioral correlations.
We failed to detect any association of TMEM106B in the Manchester or London cohort either when analyzed individually or when combined.
We finally discuss options for the implementation of high-quality functional and imaging readout protocols.
We find a massive increase in VMRs with age and in regions of the genome associated with open chromatin and neurotransmission.
We find an increase in RyR2 transcripts in MCI brains compared with no cognitive impairment.
We find a positive impact of schooling on memory scores.
We find a significant association between increased heterozygosity and survival ( P = @number@ ) .
We find a strong inverse association between adult BMI and each of the five outcomes , reflecting the stigma associated with high body weight.
We find a strong positive association between unemployment rates and total suicide rates over time within states.
We find elevated perceptual thresholds for letters and word discrimination from young normal controls , to older normal controls , to early AD patients.
We find further that a mutant NuMA1 version , non-phosphorylatable at potential ATM-dependent phosphorylation sites , is poorly PARylated and induces loss of spindle bipolarity.
We find gender , race , and educational differences in class-membership probabilities.
We find increased Rho-associated kinase ( ROCK ) signaling and M2 characteristics in eyes of aged mice , revealing immune changes in aging.
We find moderate dependencies of the network on gender.
We find multiple architectural and cellular features that precede thymic involution , including disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells.
We find no age-related change in induction magnitude in the @number@ Hz condition.
We find no such evidence in our Chinese sample.
We find @number@ de novo mutations , both single nucleotide polymorphisms and indels , and determine the parent of origin of @number@
We find parental use of a nursing home decreases expectations that one's children will provide informal care , consistent with the demonstration effect.
We find people's age experiences are multidimensional and multidirectional , incorporating narratives of progress and decline.
We find positive migration effects on body mass index ( BMI ) , mobility and self-reported health.
We find SMRT expression and its occupancy on peroxisome proliferator-activated receptor ( PPAR ) target gene promoters are increased with age in major metabolic tissues.
We find substantial decoupling of mRNA and protein expression levels in aging , but not in development.
We find substantial enrichment in genes for which knockdown increased lifespan.
We find surprising evidence that at @number@ months the LOC has functional specialization that is highly similar to adults.
We find that activities of daily life , height , and low hemoglobin levels covary with subjective expectations in expected directions.
We find that adult movement produces significantly lower persistence than larval dispersal , all other factors being equal.
We find that ageing drivers experience more crashes at intersections than younger drivers , especially crashes involving turning movements.
We find that age-only models contain significant omitted variable bias , and that the relationship between age and health varies significantly across birth cohorts.
We find that ANS fluorescence tracks with the binding of the molecular chaperone Hsp70 in compartments where Hsp70 is present.
We find that combining p27 Interleukin ( IL ) -6 engages similar signaling mechanisms to leptin.
We find that commonly assumed immune correlates are poor predictors of clinical protection in children.
We find that conventional transcription activator-like effectors ( TALEs ) tend to form protein aggregates , thereby compromising their performance in imaging applications.
We find that credit scores are negatively correlated with cardiovascular disease risk.
We find that CSB facilitates HR and represses NHEJ.
We find that cumulative exposure to neighborhood disadvantage has significant effects on functional decline and mortality.
We find that DNA damage accumulation does not decrease the adult life span of post-mitotic tissue.
We find that dopaminergic neurons are particularly vulnerable to changes in FOXO3 activity in the substantia nigra.
We find that economic conditions at birth significantly influence cognitive functioning late in life in various domains.
We find that epigenetic aging strongly affects stem cell heterogeneity and that homing at stem cell niches retards epigenetic aging.
We find that favorable childhood conditions exert a negative direct impact on survival probability at senior ages , possibly resulting from mortality selection.
We find that female consumers show high acceptance for some functional dairy products , such as yogurt enriched with calcium , fiber and probiotics.
We find that hSuv3 helicase and ATPase activity in vitro is strictly dependent on the presence of specific divalent cations.
We find that in patients with striatal dopaminergic neurodegeneration serum BDNF levels decrease along with loss in striatal DAT binding.
We find that iPSCs from older donors retain an epigenetic signature of age , which can be reduced through passaging.
We find that islet endocrine cells from older donors display increased levels of transcriptional noise and potential fate drift.
We find that low reward , high effort , effort to reward ratio , and effort to control ratio were all predictors of increasing frailty.
We find that lysine @number@ is important for GEF recognition , because mutations at this position impaired GEF-mediated nucleotide exchange.
We find that multiphoton fluorescence imaging of ( ANS ) can be used to assess cellular responses to protein misfolding stresses.
We find that network characteristics and emotional support are associated with hypertension diagnosis and control.
We find that numeracy and cognitive reflection are positively associated with enrollment likelihood and that they are more important determinants of enrollment than age.
We find that Sirt4 affects mitochondrial uncoupling via the adenine nucleotide translocator @number@ ( ANT2 ) .
We find that Subdued expressed in heterologous cells mediates a strong chloride conductance in the presence of both heat and calcium ions.
We find that the frequency of point mutations increases ~5-fold over the course of @number@ years of life.
We find that the intensities of gammaH2AX foci appear significantly weaker in the G0 / G1 phase HGPS cells compared to control cells.
We find that the majority of senescence-associated miRNAs demonstrate tissue-specific effects.
We find that the resulting fluctuating signal becomes dynamically complex.
We find that these miRNAs genetically interact with genes in the DNA damage checkpoint response pathway and in the insulin signaling pathway.
We find that UDL in total increased the incidence of marital breakdown by about @number@ %.
We find that , while parental needs are important , cohabitation is influenced to a larger extent by the costs and gains of children.
We find that wives provide emotion work regardless of their own health status.
We find that α and β haemoglobin ( Hba and Hbb ) proteins are altered in their distribution in mitochondrial fractions from degenerating brain.
We find that ΔRV decrease with age by just over one standard deviation when comparing young with old participants ( p < 0.01 ) .
We first analyzed @number@ single-nucleotide polymorphisms ( SNPs ) in @number@ healthy controls , finding @number@ SNPs associated with telomere length at P < @number@
We first describe a theory-based framework for designing effective messages for patients.
We first evaluated its maturity in existing literature and then posed analytical questions to clarify aspects found to be only partially mature.
We first focus on gene regulatory networks ( GRNs ) that govern the differentiation of retinal photoreceptors and modulate adaptive response during aging.
We first identified dimensions of a battery of @number@ neuropsychological tests , and regional measures of Alzheimer's disease ( AD ) neuropathology.
We first investigated whether there were observable episodic and autobiographical memory impairments associated with mTBI within an otherwise healthy young group.
We firstly confirmed that long-term cultured skin equivalents are still morphologically consistent and functionally active even after @number@ days of culture.
We first measured CK2 activity in articular chondrocytes of 6- , 21- and 30-month-old rats.
We first measured the fusion limits in these participants using two 3D stereoscopic images.
We first observed robust segmentation of both simulated T2-hypointensities and gray-matter regions known to be T2-hypointense.
We first present simple graphical and numerical summaries that can be used in a binary logistic model.
We first provide estimates of age-standardized and age-specific disability prevalence by state.
We first re-analyzed the blood concentration data for metoprolol in @number@ Japanese patients using a nonlinear mixed effects model.
We first show that processing of dynamic emotional faces occurs across multiple brain regions in both infants and adults.
We first tested each gene for increased or decreased burden of rare variants in cases compared to controls.
We first tested our algorithm on simulated data to elucidate the factors affecting the identification of the pacemaker model.
We first tested the underlying factor structure of the MCQ in a large sample of @number@ adults from aged from @number@ to @number@ years.
We first used descriptive analysis to identify those in poor and good health.
We fit Cox proportional hazards models adjusted for age , sex , education , diabetes duration , and markers of clinical control.
We fit linear regression models adjusted for age , income , education , body mass index , physical activity , smoking , and alcohol intake.
We fitted covariate-adjusted regression models accounting for repeated measures.
We fitted gene-environment interaction models pointwise , to visualize brain regions where age , sex , SES and IQ modulate heritability of fiber integrity.
We fitted the model's free parameters , including the average growth time of one malignant cell into a lethal tumor.
We focused on analyzing the P3a and the N2 in both the target stimulus and the immediately succeeding irrelevant stimulus.
We focused on miR-144 which was significantly down-regulated in CCA tissues.
We focused on shift work through midlife ( here , ages 58-68 years ) because cognitive decline is thought to begin during this period.
We focused on the association between chronic diseases , socioeconomic factors , and being hypertensive.
We focused on the hormonal aging and on the interaction between HRT use and the modulation of miR-21 , miR-146a and classical inflammation markers.
We focused on the subset of cases with neuropathology-confirmed hippocampal sclerosis ( n = 106 ) .
We focused on three generations of genotyped participants of the Framingham Heart Study ( FHS ) .
We focused our analyses on the anterior cingulate cortex as a key structure of cognitive control of emotion.
We focus in particular on recent findings on sirtuins for prevention of neurodegenerative diseases.
We focus on exemplars in biobanking and newborn screening to illustrate a variety of current stakeholder engagement in policy-making efforts.
We focus on mildly and moderately impaired people , aged 65 + years.
We focus on prediction of treatment toxicity , mortality and the role of GA in the decision-making process.
We focus on the mechanisms of hCC dimerization , oligomerization , and amyloid formation.
We focus on whether the changes in these processes precede or succeed the earliest symptoms in AD patients , i.e. , minimal cognitive impairment.
We focus our attention specifically on proteins and metabolites.
We focus this review on the interplay between PPARγ and canonical WNT / β-catenin pathway and the anti-inflammatory role of PPARγ in exudative AMD.
We followed a guideline for cross-cultural adaptation and subsequently conducted factor analysis with @number@ responses from over @number@ professions.
We followed @number@ members of the Framingham Offspring cohort who were free of T2D at baseline from @number@ to @number@
We followed @number@ U.S. Chinese older adults who agreed to participate in the study within @number@ to @number@
We followed our initial discoveries with network and eQTL analysis of candidate signals in tissues.
We followed the design approach of other morphometric tools , expanding it to create a user-friendly guide ( divided into six age groupings ) .
We followed the evolution of each one by means of the administration on three occasions of an extensive battery of neuropsychological tests.
We followed them for 1-17 years ( mean @number@ years ) .
We formulated a novel hypothesis that insulin resistance can be beneficial in obese humans , insofar as it does not cause glucose dysmetabolism.
We formulated the tested hypothesis before data collection.
We found a behavioral impairment in pattern separation in a sample of healthy older adults compared with young controls.
We found a bilateral MTR decrease in the temporal , cingulate , parietal , and prefrontal areas.
We found a c.964T > C synonymous variation in exon @number@
We found accumulation of autophagy agonisitic free fatty acids , whereas triglyceride levels were strongly decreased.
We found a continuous pattern of increase from 18-75 , however frequency of allele @number@ carriers decreased in our oldest age groups.
We found a degeneration of some motoneurons in the spinal cord accompanied by accumulations of ubiquitinated proteins.
We found a female-specific genetic association of rs6265 with AD and a gender-related messenger RNA expression of BDNF in brain tissues of AD patients.
We found a functional requirement of PEG3 for TFEB transcriptional induction and nuclear translocation in human umbilical vein endothelial and PAER2 cells.
We found age differences for nonfocal , but not focal , prospective-memory performance.
We found age-related decrease in ACTH level that is a known hypophysial stimulant of cortisol and cortisol precursor synthesis in adrenal glands.
We found age-related increases in INT , NP , and IOR , independent of task demand.
We found age-related increases in the structural connectivity between the PFC and posterior brain regions.
We found a homogeneous neuropsychological profile among SCA subgroups with a prominent role of frontal dysfunction particularly , attention , memory , and executive functions.
We found a negative relationship between the utilization of preventive care and hospitalization care in terms of length of stay and medical expenditures.
We found an increase of shortest path length and a decrease of global efficiency in preclinical AD.
We found an interaction between marital status and age.
We found another interaction , between HFE 63HH and TF -2AA , markedly modified by age.
We found an overall age-related shift in band power from lower to higher frequencies , especially for females.
We found a positive association of SCR and fMRI-activation only among seniors in areas processing sensorimotor performance , arousal and emotional perception.
We found a positive association of YY1 expression and mtDNA content in controls.
We found a positive correlation between serum BDNF levels and striatal DAT availability ( p < @number@ R ( @number@ ) = @number@ ) .
We found a positive correlation of age with DNA strand breaks but not with FPG-sensitive sites.
We found a predominance of women in both groups : @percent@ and @percent@ , respectively.
We found a progressive improvement in the ability of discrimination from @number@ to @number@ years , which parallels the development of fine motor control.
We found a relatively lower slope increase of FSH in older patients compared to that of AFC and AMH.
We found a significant association between PTPN22 @number@ C / T SNP and T1D and GD.
We found a significant association between TSH elevation and all-cause mortality in this cohort of elderly persons with CKD.
We found a significant correlation of the mtDNA control region heteroplasmy between sibs , confirming a genetic influence on this phenomenon.
We found a significant decrease in chromatic sensitivity due to ageing , in particular along the tritan line.
We found a significant decrease in mitochondrial membrane potential in samples from aged donors , accompanied by a significant increase in ROS levels.
We found a significant improvement in performance , but the amount of improvement was equivalent for both age groups.
We found a significant increase in phase shift with age in @number@ of @number@ cortical regions , concurrent with current understanding of cortical iron accumulation.
We found a significant increase in Stroop effects for AD patients , across studies.
We found a significant interaction between stress and insomnia with an impact on serum BDNF levels.
We found a significant interaction effect of carrying APOE ε4 and being Chinese.
We found a significant interaction of age ≥80 on the risk of stroke with PI ( p = @number@ ) .
We found a significant interaction with diabetes-where diabetics were more susceptible to the effect of BC-for both sICAM-1 and sVCAM-1.
We found a significantly increased expression of p16 ( INK4A ) in BCP-ALLs with MLL rearrangement.
We found a significantly positive association between reduced attentional facilitation , as measured by the N1 ERP component , and falls risk.
We found a significant positive correlation between LLAC and CAC ( rho = 0.6 ; p < 0.01 ) .
We found a strong evidence of non-linearity between TPA and the 10th survival percentile ( P-value < @number@ ) .
We found a strong positive correlation between an individual's age and the frequency of CD56 + monocytes.
We found a very significant increase in average longevity ( @percent@ ) of the cyclists when compared with the general population.
We found a weak correlation between total Knowledge scores and total Attitude scores ( rho = 0.13 , p < 0.001 ) .
We found a wide range of mtDNA copies , which resulted in a high degree of overlap between groups.
We found biochemical evidence suggesting that resveratrol protects against Wallerian degeneration by promoting the dissociation of SIRT1 and DBC1 in cultured ganglia.
We found both increased and decreased connectivity within portions of the motor cortical and cerebellar networks after adjusting for covariates.
We found carotid damage in @percent@ of the diabetics , @percent@ of the hypertensive patients and @percent@ of the controls.
We found chronic inflammation in > 70% of men on autopsy.
We found clear evidence for long-term cognitive deficits associated with severe TBI.
We found cognitive ability , economic resources , social status , social network , and health behavior explain all of the education gradients.
We found comparable rates from countries in North America , Australia , and Europe outside of Scandinavia.
We found correlation between expression AIF and CGRP at pineal gland , but the correlation at thymus wasn't found.
We found correlation between the VAS and the MMP-9 expression.
We found decreased cortical thickness ( CTh ) and volume in cortical and subcortical structures in symptomatic mutation carriers , with progressive loss over time.
We found different directions of cardiac remodeling with normotensive and hypertensive loads.
We found distinctly different breath pattern and distribution profiles of VOCs in the centenarians.
We found eight risk variants associated with PCSM : One predicted an increased risk of PCSM , while seven were associated with decreased risk.
We found elevated antibody responses to TIV and expression of inflammatory cytokines in the serum of females compared with males regardless of age.
We found Emotionality to be positively , but Shyness negatively associated with brain activity linked with both cognitive and emotional humor components.
We found evidence against substantially faster SM decline in HIV infected versus similar-aged controls.
We found exceptionally elevated risk of second ovarian endometrioid carcinoma after endometrial cancer of the same histology or of early onset.
We found extensive and overlapping significant annual decreases in fractional anisotropy , and increases in axial diffusivity , radial diffusivity , and mean diffusivity.
We found frequency effects but neither an AoA effect nor a language by AoA interaction.
We found good evidence for construct validity with a subsample tested in person.
We found higher 85 + / 65 + distribution ratios , indicating enhanced longevity , in the coastal and southern regions of China.
We found higher frequency of BCL2-JH and BCR-ABL ( major ) translocations with aging.
We found hints for a correlation between C9orf72 repeat length and the age of onset.
We found HIV infection , cigarette smoking , quality of life , and stage of the menopause transition to be associated with severe menopause symptoms.
We found impaired localization of both KIF14 and CRIK at the midbody in patient-derived fibroblasts.
We found increased risk of death and disability as wealth decreased.
We found in our diabetic patients the predisposition alleles HLA-DRB1 03 , HLA-DRB1 04 and particularly their combination.
We found , in the high volume physical activity individuals , a higher degree of differentiation in CD4 + T-lymphocytes.
We found Klotho KD augmented NF-κB p65 expression , and abrogated the ability of GABA to block NF-κB activation.
We found little support for associations between cognitive decline and patella or blood lead , which provide integrated measures of exposure over shorter timeframes.
We found marked alterations of 5hmC amount during ageing.
We found microglia activation in normal white matter of controls and that the degree of activation increased with age.
We found MIP mRNA expression , MIP protein levels , and MIP phosphatase activity significantly decreased in old Wt mice.
We found multiple somatic mutations and polymorphisms in both RTS and LFS patient cells.
We found naturally acquired antibodies to all three proteins in all age groups against all three antigens.
We found new sex differences of bone density decay in the skull that are potentially of relevance for the general understanding of bone degradation processes.
We found no age differences in accuracy.
We found no association between age and [ 18F ] -FEPPA VT in WM-ROIs.
We found no association between spinal pain and cardiovascular-specific mortality.
We found no association between SRH and toxicity or mortality.
We found no association between testosterone group assignment and calf muscle mass and @number@ m walking speed.
We found no associations between HRT use and telomere length.
We found no associations between structural covariance and performance , suggesting that other factors underlie the performance differences seen between carriers and non-carriers.
We found no association with the presence of rod-shaped microglia and a self-reported history of a TBI.
We found no carriers of > 30 repeats.
We found no changes to the size of the elbow flexor compartment over @number@ days of admission.
We found no clear associations with measured hypertension.
We found no correlation of segmental T2 values with maximal systolic , diastolic strain or heart rate.
We found no correlation with age and neuron number.
We found no correlation with increasing iron concentrations with age.
We found no difference between the two groups in C-reactive protein levels or in the distribution of C-reactive protein haplotypes.
We found no difference in LTL between the middle-aged LLS offspring and their spouses ( β = 0.006 , P = 0.932 ) .
We found no differences in the effects of stimulation between young and older adults.
We found no differences in the monocyte / macrophage content between men ( n = @number@ ) and women ( n = @number@ ) .
We found no effect of donepezil treatment on BDNF level.
We found no effect of perimenopausal age range on LTG and MHD clearance.
We found no evidence of an interaction with obesity.
We found no evidence of heterogeneity by cognitive test.
We found no evidence of higher cognitive performance in young ɛ4 carriers , or cognitive deficits in older ɛ4 carriers.
We found no evidence that any of the excitability measures depended on electrode separation , conduction time or apparent velocity.
We found no evidence that elevated inflammation or HPA-function mediated any of the associations.
We found no evident pattern between the expected chemosensitivity of different cancers and the probability for patients to receive chemotherapy close to death.
We found no immediate telomere shortening in adolescents with AS.
We found no main effects of the candidate genes on ADHD symptoms throughout adolescence.
We found no overall effect of micronutrient supplements on lymphocyte proliferative responses to phytohaemagglutinin or purified protein derivatives in HIV-negative and HIV-positive TB patients.
We found no overall sex effects for comprehension of affective prosody.
We found no policy impacts on satisfaction with health conditions.
We found no repeat interruptions to be present , and we describe differences between sequencing and traditional sizing methods.
We found no significant association of NSES with AL.
We found no significant differences among monitors for those who walked without aids ( p = @number@ ) .
We found no significant differences between early and late postmenopausal women in the adjusted analysis.
We found no significant differences between groups on patient cognitive or functional ability , or caregiver anxiety , depression , burden , or relationship satisfaction.
We found no significant differences in change in CD4 count and viral load.
We found no significant differences or age correlations in posterior cingulate cortex connectivity.
We found no significant genetic correlations between low as well as high frequencies of hearing and cognition.
We found no significant impact of sex on orthostatic changes of HR and BP.
We found no significantly genetic correlation for cognition with handgrip strength , FTSST , near visual acuity , and number of teeth lost.
We found no significant Osbpl2 upregulation at the mRNA level in homozygous Mir96 mutant mice.
We found no significant sex differences.
We found no significant statistical relationship between body weight , abdominal circumference and concentration TAG , hypertension in patients and controls.
We found no statistically significant associations between any of the elemental constituents in PM2.5 or PM10 and CVD mortality in the pooled analysis.
We found no statistically significant differences between the men and women in either age group , and so we then pooled our data across sex.
We found no statistically significant differences between the two sample-collection approaches for any of the parameters measured.
We found no statistically significant differences in outcomes between AHOD and TAHOD participants for all endpoints examined.
We found no statistically significant differences in WMH , whole brain , or hippocampal volume between subjects with and without delirium.
We found no total or gender-specific association of T2DM with MCI or MCI subtypes in the old-aged group.
We found no trend of including older participants in RCTs on LBP over time.
We found @number@ novel missense variants in patients and @number@ known missense variants in control subjects.
We found @number@ patents , out of which @number@ were evaluated using inclusion criteria as application of natural products with photoprotective or photoaging application.
We found @number@ studies , for a total of @number@ comparisons on different indices of HPA axis functioning.
We found @number@ themes and @number@ categories.
We found one AR binding site in the promoter region and two functional androgen-responsive elements in the sequence.
We found only small sociodemographic differences across age , gender , and education group.
We found out a younger biological age in sport veterans , who were carrying out dynamic exertions.
We found overall modulation of visual and auditory processing during cross-modal selective attention in both age groups.
We found peripheric muscle strength be associated with MIP and PCF but not with MEP or any other spirometric parameters.
We found prevalence rates of @percent@ , @percent@ , and @percent@ for hypertension , dyslipidemia , and diabetes , respectively.
We found reliable hippocampal signal response across both block- and event-related designs in the right hippocampus.
We found RFs of various sizes and shapes.
We found rs7647481A nonrisk allele binding of Yin Yang @number@ ( YY1 ) , confirmed by allele-specific chromatin immunoprecipitation in primary adipocytes.
We found RUNX1 is a target of AR and regulated positively by androgen.
We found selective differences between neural networks underlying the basic emotions in limbic and insular brain regions.
We found significant alterations of quantitative parameters in DLB compared to controls.
We found significant associations between plasma %H3K27me3 levels and risk of myelomeningocele ( P < 0.05 ) .
We found significant associations between reductions in cortical thickness and age-related improvements in performance on both working memory and cognitive control tasks.
We found significant differences between adults and older adults.
We found significant implications of cataract surgery on decreasing IOP in the studied group of patients suffering from glaucoma compared to the patients without glaucoma.
We found significantly lower internal LOC and higher external LOC in the MCI group than the HC group.
We found similar but weaker patterns of responses in 16-month-olds.
We found small age differences in FOK magnitudes but major age differences in memory retrieval choices that mirrored retrieval use in the standard NP task.
We found smaller reductions in our analyses of \ "other hospitalizations \ " ( OR : @number@ @percent@ CI , @number@.95-0.98 ) .
We found social goal progress to positively covary with support and negatively covary with hindrance.
We found some evidence for stronger associations of Ɛ4 with sleep duration among African Americans.
We found some evidence of reduced mobility limitations for both skipped-generation and nonresidential caregivers relative to noncaregivers.
We found some evidence that walking speed and the fluid cognitive domains of executive function and processing speed may change in parallel with increasing age.
We found statistically significant differences in the proportions of subjects with the A827G mutation among the various age-related hearing loss groups and normal controls.
We found strict adherence to study-provided diets and that participants found the diet tolerable , with no adverse clinical findings or weight change.
We found stronger intrinsic functional connectivity in the FPC and DMN in bilinguals than in monolinguals.
We found substantial between-country differences in the legal status of migrant caregivers and regulations regarding working and living conditions and drew @number@ conclusions.
We found T-bet expressed in unstimulated memory more than naïve B cells , and more in young individuals.
We found that 20GPPD induced an increase in HA production by elevating hyaluronan synthase @number@ ( HAS2 ) expression in human keratinocytes.
We found that 2-year-olds were likely to interpret another person's nonrandom sampling behavior as a cue for a preference different from their own.
We found that accuracy of cognitive mapping was positively correlated with left frontal theta activity during encoding in young adults but not in older individuals.
We found that AD was present in @number@ of these narcoleptics , a prevalence that is similar to that of the general population.
We found that after the age of @number@ years , the strategy and ability trajectories saliently diverge.
We found that age and life stage shaped participants ' decision making about care.
We found that age differences in exploration time were considerably reduced when this component process was facilitated by providing a category name.
We found that age , gender , BMI , and smoking status were significant predictors for haemostasis factors.
We found that age group identification was a good predictor of responses to status threat , particularly among young adults.
We found that age , health , and education were also important factors.
We found that age-related dysregulation of BMDMs is associated with abnormal overexpression of the anti-inflammatory interleukin-10.
We found that age stereotypes have become more negative in a linear way over @number@ years.
We found that age was one of the strongest determinants for the presence of rod-shaped microglia in the hippocampus and the cortex.
We found that aging and male gender were associated with prevalence of corneal blindness.
We found that AIMP3 / p18 expression significantly increased in senescent hMSCs and in aged mouse bone marrow-derived MSCs ( mBM-MSCs ) .
We found that all three cortical networks exhibited small-world properties and those strong interhemispheric correlations existed between bilaterally homologous regions.
We found that although the ability make optimal decisions declines with age , there is still much individual variability in how this deterioration occurs.
We found that apnea-hypopnea index was greater than or equal to @number@ in @number@ ( @percent@ ) subjects , consistent with OSAS.
We found that ARFGAP3 interacted with paxillin , a focal adhesion adaptor protein that is important for cell mobility and migration.
We found that artesunate ( ART ) inhibited the growth of MCF-7 and MDA-MB-231 breast cancer cells.
We found that as already shown for oAβ , also oTau can bind to amyloid precursor protein ( APP ) .
We found that a significant reduction in human dengue cases can be obtained provided that Wolbachia-carrying mosquitoes persist when competing with mosquitoes without Wolbachia.
We found that atrophic myofibers could be rescued by home-based Functional Electrical Stimulation ( h-bFES ) , using purpose developed stimulators and electrodes.
We found that ATXN2 intermediate-length polyglutamine expansions greater than @number@ and @number@ repeats were associated with sporadic ALS.
We found that basal amino acid transporter expression was similar in young and older adults ( P > @number@ ) .
We found that BOLD variability in a neocortical region was negatively related to age and positively related to SWM performance.
We found that both of these factors significantly suppressed gelsolin-induced cardiac hypertrophy through p38 / GATA4 signaling pathway.
We found that both reference panel and GWAS chip density affect the imputation of low frequency and rare variants.
We found that both RNFLT ( p = @number@ GEE ) and TMV ( p = @number@ GEE ) associate with BPF.
We found that both small-worldness and modularity were negatively correlated with increasing age but that this decline was relatively slow.
We found that both training groups improved in the training task.
We found that breast tumorigenesis is accompanied by collagen crosslinking , ECM stiffening , and increased focal adhesions.
We found that cells expressing Sox2 and / or Sox3 are present in the ventricular zone of regenerative animals and decrease in non-regenerative froglets.
We found that children with BA chronological age discrepancy fitted better to the BA BMD reference curve than to the chronological age BMD reference curve.
We found that chloride concentration decreased with age in hepatic cytosol but increased in liver mitochondria.
We found that co-administration with bovine serum albumin increased levels of insulin in most brain regions.
We found that coating the culture surface coated with @number@ μg cm Alzheimer's disease and related dementias ( ADRD ) affect over @number@ million Americans.
We found that combining the massaging device with a skin anti-aging formulation amplified the beneficial effects of the cream.
We found that conventionally monitored somatosensory evoked potentials at least partly reflected progressive dysphagia.
We found that cord blood ECFC were characterised by lower pro-inflammatory and pro-thrombotic gene expression as compared to adult ECFC.
We found that cordycepin suppressed IL-1β-stimulated GAG release.
We found that cranberry slightly extended life span in males fed with the low sugar-high protein diet but not with other diets.
We found that CSB interacts with DNA in two principle ways : by simple binding and a more complex association that involves gross DNA distortion.
We found that cyclin E interacts with distinct sets of proteins in different compartments.
We found that cyclin K is highly expressed in mammalian testes in a developmentally regulated manner.
We found that decompositions of CBF , GMV and fALFF all included components for which scores were significantly associated with age.
We found that decreased cell density significantly increases levels of Aβ40 , Aβ42 , total Aβ , and the ratio of Aβ42 : Aβ40.
We found that distinct haplotypes of the IL-10 gene associated with handgrip strength.
We found that DNA extracted from stored samples was of good quality with a yield of extraction as expected.
We found that DNA glycosylases were efficiently recruited to DNA damage in heterochromatin , as well as in euchromatin.
We found that DNA methylation increases throughout the lifespan.
We found that doenjang supplementation decreased visceral fat accumulation and aging most effectively in subjects with PPAR-γ polymorphisms.
We found that DR is effective in reducing total and visceral adipose mass and improving inflammatory cytokines profile and adiponectin / leptin ratio.
We found that E2-treated rats had significantly improving ischemia-induced depression-like behaviors in the forced-swimming test and sucrose preference test , compared to vehicle-treated group.
We found that each group of DEGs was predominantly associated with alterations in only one type among the three histone tri-methylations.
We found that EEG power changed as a function of age , and that the age-related changes depended on sex and frequency band.
We found that EGb inhibited IL-1-induced production of chemokines , which in turn resulted in attenuation of THP-1 cell migration toward EGb-treated cell culture medium.
We found that endogenous miR-21 is upregulated in osteoarthritis patients , and overexpression of miR-21 could attenuate the process of chondrogenesis.
We found that endogenous SirT1 protein expression inversely correlated with donor age.
We found that EP impairs HMGB1 secretion by MM cells leading to reduced RAGE expression and NF-κB activation.
We found that Eucalyptus globulus suppressed the expression of MMPs and IL-6 , but increased the expression of TGF-β1 and procollagen type @number@
We found that exogenously introduced zinc induced a potent de novo synthesis of MTs as well as a strong inhibition of pro-inflammatory cytokines.
We found that expression of progerin in iPSC-derived fibroblasts and neurons induces multiple aging-related markers and characteristics , including dopamine-specific phenotypes such as neuromelanin accumulation.
We found that externally driven and purely desire-driven acquirements led to a higher risk of suboptimal use and low levels of need satisfaction.
We found that extracellular PPIA is a mediator of neuroinflammation in ALS.
We found that FBG1 is a promiscuous ubiquitin ligase with many partners.
We found that few studies took measures to reduce risks of bias , and substantial heterogeneity in the reported effects of d-galactose in included studies.
We found that fibroblasts from old donors exhibited an increase in rigidity of ∼60% with respect to cells of the youngest donors.
We found that for frequencies less than @number@ Hz , RMSE generally decreased , while RMSE normalized to disk motion amplitude generally increased.
We found that FXR and TGR5 expression levels are decreased in the aging kidney and that caloric restriction prevents these age-related decreases.
We found that GluR2 immunoreactivity and mRNA were up-regulated in SIVD , but remained unchanged in MIX.
We found that Gly , Hyp , Glu , and Ala directly scavenged ( @number@ ) O ( @number@ ) .
We found that GM1 bound to macrophage mannose receptor ( MMR / CD206 ) and common gamma chain ( γc ) .
We found that good readers were more likely to experience relative improvements in VIQ over time , with the reverse true for poor readers.
We found that greater hippocampal activation at baseline was associated with increased Aβ accumulation.
We found that greater SDBOLD was associated with better fluid abilities and memory.
We found that green tea catechin and β-cryptoxanthin in Japanese mandarin oranges prevented brain atrophy and cognitive dysfunction.
We found that hAMSC conditioned media ( CM ) inhibited prostate cancer cells proliferation.
We found that heat shock factor Hsf1 extends chronological lifespan of S. pombe when overexpressed.
We found that HF2-BE2 could convert C to T efficiently , with up to @percent@ biallelic mutation efficiency in mouse embryos.
We found that high cognitive reflectivity was associated with greater regional gray matter density in the ventral medial prefrontal cortex.
We found that high-dose isoflavones over a course of @number@ weeks do not improve metabolic or inflammatory parameters in androgen-deprived men.
We found that higher adherence to a MeDi was associated with longer LTL among whites but not among African Americans and Hispanics.
We found that higher circulating levels of inflammatory markers were associated with lower levels of free serum triiodothyronine.
We found that higher midlife BP and longer durations of HTN predicted a higher rate of thinning in the right superior temporal gyrus.
We found that hospital nurses had less theoretical knowledge than home care nurses and nurses working at advanced wound care clinics.
We found that HSF1 bound to the JUN promoter and was necessary for its efficient response to heat shock.
We found that human Cdc45 forms a complex with the single-stranded DNA ( ssDNA ) binding protein RPA.
We found that human infant BVs are stronger than porcine BVs , and BV mechanical properties are rate dependent , but not age dependent.
We found that human iPSC-derived astrocytes secreted abundant apoE with apoE4 lipoprotein particles less lipidated compared to apoE3 particles.
We found that humans with Alzheimer's disease ( AD ) had increased levels of the Gs-coupled adenosine receptor A2A in astrocytes.
We found that hypertension , diabetes , malignancy , arthritis , cardiovascular and cerebrovascular diseases , smoking , and obesity increased the risk of ERdHP.
We found that ICRF-193 , but not bleomycin , leads to DNA damage preferentially at telomeres , which can be rescued by TRF2 inhibition.
We found that impaired mitochondria in IPF and aging lungs were associated with low expression of PTEN-induced putative kinase @number@ ( PINK1 ) .
We found that , in bimanual control , the elderly showed no preference for their dominant arm.
We found that in both groups , beta power decreased during the motor task in the electrodes over the two primary sensorimotor areas.
We found that individuals who were disadvantaged in childhood were more likely to have their first child as teenagers or in early young adulthood.
We found that individuals with Parkinson's disease had a marked decrease in nodal and global efficiency compared to healthy age-matched controls.
We found that interstitial area gradually increases with age from @number@ ± @percent@ in newborns to @number@ ± @percent@ in adults.
We found that iron in the cortex was @percent@ higher than age-matched controls at an early stage , corresponding to the commencement of plaque formation.
We found that kalirin reduction in APPswe / PSEN1dE9 mice significantly attenuated psychosis-associated behavior at @number@ months of age without changing spatial memory performance.
We found that larger PFC volume and greater PFC thickness were associated with better executive performance.
We found that limiting the amount of exercise , by removing the running wheels , leads to loss of scale-invariant properties in all age groups.
We found that looking at the horizon significantly affected the multifractality of standing body , but did not systematically influence the spatial magnitude of sway.
We found that loss of UHRF1 led to retarded lesion processing and reduced recruitment of ICL repair nucleases to the site of DNA damage.
We found that lower educational attainment was associated with shorter telomere length after controlling statistically for biological and behavioral covariates.
We found that lung cancer growth depends on short-distance cues produced by the cancer niche in a p38-dependent manner.
We found that LY333531 significantly reduced AGEs-induced macrophage adhesion to HUVEC.
We found that macroscopic infarcts are common , lower the threshold for cognitive impairment , and often coexist with Alzheimer's disease pathology.
We found that married older adults had better actigraph-estimated but not self-reported sleep characteristics than the unmarried.
We found that men compared to women were more likely to be successful.
We found that MEPs were less specifically facilitated during planning in older as compared to younger adults , as indicated by an Age×Condition×Muscle interaction.
We found that methylation levels of @number@ CpGs belonging to @number@ genes were significantly correlated with maternal age.
We found that MHY908-fed old rats suppressed phosphorylation of IRS / Akt and induced FoxO1 activation , leading to increased expression of MnSOD and catalase.
We found that miR-34a was highly expressed in aortas isolated from old mice.
We found that miR-378a-3p expression was downregulated in TamR and LTED cells as well as in clinical breast cancer tissues.
We found that most sphingomyelin species increased with age.
We found that multiple pathologies determine the overall burden of dementia.
We found that musculoskeletal disorders increased with age , however our results showed no variation in prevalence of chronic disorders between @number@ and @number@
We found that Nampt expression was progressively elevated during BM-MSCs osteogenic differentiation.
We found that neutralizing eTau reduces Aβ levels in vitro in primary human cortical neurons where exogenously adding eTau increases Aβ levels.
We found that nickel-spiked sediment substantially impairs both survival from larval to adult stages and adult longevity in a concentration-dependent manner.
We found that non-Hispanic white , black , and Asian adults with extremely low education and personal income are more likely to have lower BMD.
We found that Numb depletion led to the accumulation of autophagic vacuole , as verified by RFP-LC3 staining combined with transmission electron microscopy.
We found that @number@ individuals ( @percent@ ) had psychological distress , of these , @number@ ( @percent@ ) had concomitant dementia-related mortality.
We found that older adults demonstrated disproportionately poorer performance on out-of-phase bimanual control , replicating our previous results.
We found that older adults had significantly smaller callosal area in the anterior and mid-body of the CC than young adults.
We found that older adults ' perceptions about health contain components which most medical professionals would not take into account.
We found that older adults tested in the morning and young adults did not differ on any graph metric.
We found that older participants performed as well as or better than younger participants on these four decision-making measures.
We found that our participants were characterized by selectiveness in their socializing with other people and tendency to avoid conflicts.
We found that overall classification accuracy was diminished in the elderly , driven by decreased performance on items that required chunk-based knowledge.
We found that overexpression of Beclin @number@ in HeLa cells leads to autophagosome formation as shown by intracellular autophagosomal marker LC3-II staining.
We found that overweight and obesity and / or being a lifelong non-drinker of alcohol were protective against mortality.
We found that OXM dose- and time-dependently increased cell viability and protected cells from glutamate toxicity and oxidative stress.
We found that participants particularly used their MBSR training for coping with medical procedures , and managing both depression and anger.
We found that participants using memantine had a lower MMSE score at M0 compared to those without memantine ( P = 0.006 ) .
We found that patients with dementia exhibited impairment in all cognitive abilities in both basic and instrumental activities.
We found that patients with PD showed significantly less reward-related learning improvements compared to HCs.
We found that @percent@ ( 101 / 476 ) of the fully reviewed articles were excluded because of a lack of health outcomes.
We found that pharmacologic treatments that either inhibit autophagosome formation or block the fusion of autophagosomes to endolysosomal compartments caused an increase in C99 levels.
We found that PhS1P promoted the activity of EGF in vitro.
We found that physically active leisure participation leads to subjective well-being for both middle-aged men and women.
We found that pioarachnoidal infundibulum was prone to age-related involutive changes.
We found that plaques started to appear at @number@ weeks , then exhibited a time dependent increase and differential distribution along the cord.
We found that Plin2 expression increases with age , this phenomenon being particularly evident in patients.
We found that Plin2 expression strongly correlates with increased p53 activation and reduced IGF-1 expression.
We found that purified Spartan has a DNA-dependent protease activity degrading certain proteins bound to DNA.
We found that rapamycin decreased HIF-1 and lactate levels in proliferating and senescent cells in vitro.
We found that Rb inactivation promotes the reprogramming of differentiated cells to a pluripotent state.
We found that RCAN1 was significantly upregulated in large vessels with low branching frequencies when compared with small vessels with high branching frequencies.
We found that relative to errorless learning , trial-and-error learning increased target memory in the conceptual condition but decreased it in the lexical condition.
We found that resveratrol exerts an inhibitory effect on DC surface maturation marker and RAGE up-regulation in response to AGE-albumin.
We found that SC integrity is maintained by interconnected and coordinated functions of Angpt-Tie2 signaling , AHO , and Prox1 activity.
We found that SEA increased the expression of P27 protein , whereas it inhibited the expression of SKP2 and FoxO3a.
We found that senescent human dermal fibroblast ( HDF ) conditioned medium ( CM ) significantly enhanced stem cell migration compared with young HDF CM.
We found that several epothilones have significantly greater brain penetration than the taxanes.
We found that several proteins ( primarily CgA and FABP ) were related to either brain atrophy or CSF biomarkers.
We found that Sirt2 overexpression decreased cell proliferation and colony formation capacity.
We found that skin wrinkling did not improve dexterity in handling wet objects nor did it affect any aspect of touch sensitivity measured.
We found that SM22α-Cre-mediated Eng deletion in the embryo caused AVMs in the postnatal brain , spinal cord , and intestines.
We found that SMFE inhibits glycation reaction between BSA and glucose.
We found that smoking was associated with age at FMP and modified associations of AMH and inhibin B with age at FMP.
We found that STNs were more difficult to delineate in PD as reflected by a lower inter-rater agreement when compared to HCs.
We found that structural variations in the caudate nucleus contributed to individual differences in financial extravagance.
We found that subjects who fell recruited fewer muscle synergies than those who recovered , suggesting a smaller motor repertoire.
We found that such optimization augmented sRAGE expression over @number@ folds of its wild-type counterpart.
We found that suppressive interactions are present from very early in postnatal life , showing no change over the age range tested.
We found that T4 treatment significantly reduced cerebral Aβ deposits and lowered Aβ levels in brain homogenates.
We found that telomerase activity was strongly induced in alveolar epithelial type @number@ cells ( AEC2 ) of the remaining lung immediately following surgery.
We found that the abundance of Fusobacterium in feces was strongly associated with the presence of colorectal cancer ( P-value < @number@ ) .
We found that the action of Aβ42 specifically in the glutamatergic motoneurons is responsible for the reduced survival.
We found that the activity of transcription factor activator protein-1 ( AP-1 ) was also inhibited by CSE treatment.
We found that the autonomic neuropathy score ( CASS ) was associated with the VACS index.
We found that the basal CD200R expression is similar in MDMs from young control , old control and PD patients.
We found that the CDR1 gene was overexpressed in the LNCaP and PC-3 PCa cell lines as compared with the PNT1A normal prostate cell line.
We found that the CR and EX volunteers were significantly leaner than the WD volunteers.
We found that the difference between CCEs measured with achromatic and colored stimuli was larger in older than in younger adults.
We found that the distribution pattern for Hcy varied by both age and gender.
We found that the dominant arm made a greater contribution , but only for specific directions.
We found that the early hyperactivation of the NMDAR is followed by loss of functional NMDAR which persists for weeks.
We found that the efficiency of the whole brain network of cortical fiber connections had an influence on processing speed and visuospatial and executive functions.
We found that the enhanced expression appeared not to affect sRAGE N-glycosylation and bioactivity.
We found that the expression of peroxisome proliferator-activated receptor γ ( PPARγ ) and thyroid hormone receptor TRβ was significantly decreased at higher passages.
We found that the extract at a concentration of @number@ microg / ml significantly enhanced percent viability and proliferation of wrinkled-skin fibroblasts.
We found that the extra-ocular muscles received no or very few TH-positive nerve fibers.
We found that the fiber number of CST fibers from the M2 was decreased in the 70s age group compared with the 20s-50s age groups.
We found that the FPE region , which is responsible for spindle and kinetochore localization , is essential for proper chromosome alignment.
We found that the global DNA methylation levels were correlated to the frailty status in middle / advanced-aged subjects but not with age.
We found that the heterogeneous nature of home contacts is critical for an epidemic transmission chain.
We found that the higher the family functioning scores , the higher the Mini-Mental State Examination scores.
We found that the higher the owner in neuroticism , the fewer t-patterns occurred per minute.
We found that the Japanese food from @number@ exhibited health benefits with respect to the stages of growth , adolescence , maturity and old age.
We found that the levels of miR-543 and miR-590-3p significantly decreased under senescence-inducing conditions , whereas the AIMP3 / p18 protein levels increased.
We found that the levels of oxidative stress were significantly increased in the hippocampus of the smoking group.
We found that the mean FA values were negatively associated with MIC-1 / GDF15 serum levels , after Bonferroni correction.
We found that the methylation levels in the ATXN3 promoter were significantly higher in SCA3 / MJD patients relative to the controls.
We found that the Na + PIC and the conductance increased during development.
We found that the older patients had a higher rate of structural abnormalities ( @percent@ ) compared with the younger cohort ( @percent@ ) .
We found that the phenotypic selection gradients differed between the sexes.
We found that the presence of extracellular catalase protected cultured neuronal cells , such as HT22 , SH-SY5Y and PC12 cells , from glutamate-induced cytotoxicity.
We found that the presence of health-related , but not social-related , possible selves was significantly associated with fewer reported depressive symptoms.
We found that there are three tau aggregation forms , soluble tau oligomer , granular tau , and fibrilar tau , before NFT formation.
We found that there is a gradient in health status , physical and cognitive functioning , and health-care use and spending across settings.
We found that the requirement of tankyrase @number@ for DNA-PKcs protein stability reflects the necessity of its PARP enzymatic activity.
We found that the results from the pilot study were suggestive but inconclusive , and thus , merit further investigation.
We found that there was no difference between the groups in safety outcomes.
We found that the senescence of hSKPs had a unique gene expression pattern that differs from reported typical senescence.
We found that these patients are becoming older and increasingly frail , as assessed by the American Association of Anesthesiology grade.
We found that these two mechanisms act synergistically toward increasing η-secretase processing of APP and Aη-α levels.
We found that these women's sexual desire and sexual activity were fluid and diverse across their life course.
We found that the tDCS effects on performance and oscillatory activity critically depended on the problem size.
We found that the two groups recruited a prevalent left frontoparietal network when performing the SWM task and a bilateral network during OWM task execution.
We found that the use of different comparison normative groups altered the subcategory diagnoses , especially when the cutoff score for impairment was conservative.
We found that thinner RNFL , GCL , and inner plexiform layer were associated with smaller gray-matter and white-matter volume.
We found that this combination therapy significantly inhibited liver cancer cells proliferation.
We found that tissue stiffness in physiological pressure range was similar among the three human sinuses.
We found that TNFα activates a STAT-dependent autocrine loop that sustains cytokine secretion and an interferon signature to lock cells into senescence.
We found that treatment with M-CSF or TGF-β1 rescued the impaired transduction efficiency of the gCAR-T by increasing the α5β1 integrin expression.
We found that verbalizing sequence-congruent information during learning is a powerful tool to generate explicit knowledge and it is especially helpful for younger adults.
We found that visual response delay and visual noise increased with age , while reliance on visual feedback , especially during compensatory tracking decreased.
We found that vitality score had no association with any of the mitochondrial respiration parameters.
We found that within-network FC changes occurred in multiple networks , including the DMN.
We found that women had longer LTL than men , but the gender difference was smaller at older ages.
We found that women , those in low income groups , and those who had driven low annual mileage were more likely to self-restrict.
We found that XRCC1 dissociates from pAR and is translocated to sites of SSBs dependent on its BRCTII domain and the function of PARG.
We found that younger mosquitoes were significantly associated with higher feeding , survival , and infection rates.
We found that α-synuclein is acetylated on lysines @number@ and @number@ and that these residues are deacetylated by sirtuin @number@
We found that γH2AX foci numbers increased in cells of late passages , with a sharp increase at passage 16-18.
We found the climax of sensibility in the third decade with age-dependent deterioration afterwards in all three tests.
We found the expected decrease in novelty P3 amplitude at frontal regions in younger adults with repetition of novel stimuli.
We found the extracellular species to be composed predominantly of a series of N-terminal fragments of tau , with no evidence of C-terminal tau fragments.
We found the presence of a cognitive impairment at the early stages of the disease , without visuospatial alterations , which appeared later.
We found these points of deflection occurred at different ages.
We found thirteen RCTs lasting 16-60 weeks and involving @number@ patients assessed for the primary endpoint ( reduction of HbA1c from baseline ) .
We found up to 800-fold enrichment of genetic risk in CBD across different levels of significance for PSP or FTD.
We found vitamin D deficiency and vitamin D insufficiency @percent@ and17.3% respectively.
We further adjusted for hypertension status to examine if vitamin D status influenced early AMD via its effects on blood pressure.
We further analyzed the level of Beclin-1 in osteosarcoma cells after chemotherapy and investigated the impact of autophagy inhibition on chemotherapy-induced cytotoxicity.
We further asked whether AT TL is related to age , anthropometric and metabolic traits.
We further assessed the Medication Adherence Report Scale ( MARS ) , and a subsample of participants were randomised to electronic adherence monitoring.
We further assess whether these relationships are contingent upon one's body mass index ( BMI ) at age @number@
We further characterized these tracts by measuring their correlation with age and education level.
We further confirmed that BM-MSCs from SLE patients showed characteristics of senescence.
We further confirmed that human OPCs expressed β-klotho and proliferated in response to FGF21 in vitro.
We further demonstrate an optimized protocol for rapid isolation of IF proteins by using lysing matrix and automated homogenization of different mouse tissues.
We further demonstrated that cyclin K is essential for embryonic stem cell maintenance.
We further demonstrate that binuclear acinar cells are terminally differentiated acinar cells.
We further demonstrate that direct and indirect effects of childhood conditions are stronger for women than they are for men.
We further demonstrate the feasibility of creating specific genetic variants.
We further determined whether the observed NE effects on memory CD8 T cells are mediated by ADRB2 using specific adrenergic receptor agonist and antagonists.
We further determine that most of these metabolic changes are regulated through autophagy.
We further discuss outstanding matters within the framework of emerging , integrative views of aging.
We further elaborate the occurrence of axonal pathology in some other neurological conditions.
We further envision that the activation and continued presence of retrotransposition contribute to age-associated tissue degeneration and pathology.
We further evaluated the performance of the signature on the mRNA level and assessed its prognostic value in the context of previously published transcriptional signatures.
We further evaluated topical HOCl use in two mouse models of NF-κB-driven epidermal disease.
We further examined an independent cohort ( @number@ proteinuria cases and @number@ controls ) for validation of the original association.
We further examined between age-group differences in the volumes of the same HC sub-regions.
We further examined homecare expenditures for a sample of non-institutionalized conditioning additionally on disability.
We further examined how each item related to measured disability using item response theory ( IRT ) .
We further examined the correlation among H scores of these markers using hierarchical clustering analysis.
We further examined the role of co-morbidities , as well as the association between sleep duration groups and memory.
We further examine the impact of genetic modulation of NF-κB signaling in muscle satellite cells or myofibers on recovery after damage.
We further expanded this interesting finding to show that both young and old adults tend to over-count small numbers , but older observers over-count more.
We further explored the effects of administering an anti-tau antibody on plasma tau.
We further find that drift has only a minimal impact on in-cis gene expression , acting primarily to stabilize pre-existing baseline expression levels.
We further find that treatment with a histone deacetylase ( HDAC ) inhibitor alters the expression of several candidate genes for schizophrenia in mouse brain.
We further focus on dissecting their cellular organization and on highlighting recently identified key molecular regulators.
We further found evidence for the association of lead SNPs in STXBP5 and STX2 with expression levels of the respective transcripts.
We further found that CSB is able to stimulate NEIL2 glycosylase activity on a 5-hydroxyl uracil lesion in a DNA bubble structure substrate in vitro.
We further found that the higher risk was largely attributed to head injuries before age @number@
We further generated a daily protein intake of @number@.7-1.8 g / kg / body mass per day.
We further hypothesized that metabolic and inflammatory derangements accompanying hyperglycaemia contribute to change in brain structure and function.
We further identified an interaction of CDK5RAP2 with the Hippo pathway components MST1 kinase and the transcriptional regulator TAZ.
We further identified CXCL10 as a robust soluble biomarker of monocyte activation , highlighting the potential utility of this chemokine as a prognostic marker.
We further identified @number@ differently expressed transcripts achieving genome-wide levels of significance.
We further investigated age-dependent changes in PFKFB3 and astrocytes in AD transgenic mice ( TgCRND8 ) that overexpress human Aβ.
We further investigated causality of the association between fasting insulin and Lp ( a ) by combined MR analysis of @number@ additional SNPs in LIFE-Adult.
We further investigated the structure of the multi-domain ERp72 , and combined the individual domains of ERp72 into a single structure.
We further investigated whether epigenetic mechanisms , such as histone acetylation and DNA methylation , were involved in galangin-induced transcriptional regulation of BACE1.
We further investigated whether the altered functional connectivity in depressed patients was associated with cognitive function and severity of depression.
We furthermore report that functional heterogeneity between young and old HSCs appears closely similar to the phenomena described for long- and short-term repopulating cells.
We furthermore showed that lower functional connectivity of the PCC was not driven by higher BOLD signal variability.
We further observed @number@ previously described missense variants ( p.Pro34Ser , p.Pro80Leu , and p.Pro96Thr ) that were also present in the matched control series.
We further observed that Rab7 activity was inhibited in Numb-depleted cells.
We further present that management strategies need to be comprehensive , incorporating physical , social , pharmacological , and psychological treatments appropriate to each case.
We further propose a novel hierarchical age estimation architecture based on adaptive age grouping.
We further revealed that SUMO-2 directly regulated apoptotic process by at least partially targeting calpain @number@ and its natural inhibitor calpastatin.
We further set out to determine if pharmacological activation of @number@'-AMP-activated protein kinase ( AMPK ) might counteract any of these functional deficits.
We further showed that miR-127 is down-regulated in breast cancer tissues and that this down-regulation is associated with up-regulation of BCL6.
We further showed that PSCA forms stable complexes with the α4 nAChR subunit and decreases nicotine-induced extracellular-signal regulated kinase phosphorylation in PC12 cells.
We further show that endocytosis inhibition does not induce autophagy even though mTORC1 inactivation is known to strongly induce autophagy.
We further show that inhibition of miR-31 overcomes the senescence-inducing effect of HDACi , and restores expression of the PcG protein BMI1.
We further show that LRRK2 recruitment to TGN46-positive Golgi-derived vesicles is modulated by constitutive LRRK2 phosphorylation by CK1α.
We further show that over the past decade HIV prevalence has increased in older age groups , while it has decreased in younger ones.
We further show that Rb-mediated cell cycle arrest and Rb-induced premature cellular senescence are effectively inhibited by Pin1 expression.
We further show that the binding of CHIP and Hsp70 to hTERT inhibits nuclear translocation of hTERT by dissociating p23.
We further show that this translation activation is abolished when Argonaute @number@ levels are knocked down after transfection with an Argonaute 2-directed siRNA.
We further show that TRF2 is a transcriptional target of WT1 and is required for proliferation , migration , and tube formation of endothelial cells.
We further show using an in vitro cluster transfer assay that mNT can transfer its clusters to NAF-1.
We further speculate on the contribution of cellular stiffness along the arterial tree to vascular wall stiffness.
We further tried to elucidate whether or not such effects are associated with beta-amyloid protein ( Aβ ) deposition.
We further used the seed-based functional connectivity to explore the remote rfMRI connectivity in aMCI.
We further validate cognitive effort discounting by benchmarking it against well-established measures of delay discounting.
We further validated miRNA data using AD postmortem brains , amyloid precursor protein transgenic mice and AD cell lines.
We further verified the transformation of LC3 from type I into type II.
We fuse these ThickNet features using multiple kernel learning to form a composite classifier.
We gathered information on sex , age at diagnosis , date of death and basis for diagnosis.
We gave priority to higher quality evidence ( e.g. , systematic reviews ) .
We generated > 5.22 billion reads and compared sequencing data between controls and AD patients.
We generated a library of iPSC lines from fibroblasts of patients with HGPS and controls , including one family trio.
We generated a mouse expressing SUR1-E1506K in place of SUR1.
We generated an extensive global map of FOXP1 binding sites and found that FOXP1 is directly involved in AR-mediated transcription.
We generated H4D24me specific antibodies and showed that H4D24me is ubiquitously present in different mouse and human cells.
We generated objective job demand measures through the Occupational Information Network ( ONET ) .
We generated the first loss-of-Hsc70-5 / mortalin-function Drosophila model.
We genotyped @number@ PD patients from the PD Cognitive Genetics Consortium for @number@ variants using the NeuroX array.
We genotyped rs17070145 and @number@ additional SNPs in @number@ late onset Alzheimer's disease ( LOAD ) patients vs. @number@ controls , including African-Americans.
We genotyped six short tandem repeat markers in the two largest families.
We genotyped study participants for two common polymorphisms in the vitamin D-binding protein gene ( rs7041 and rs4588 ) .
We had a total of @number@ combinations for controls and @number@ for cases.
We had no information regarding microvascular complications therefore a possible association between vascular health and menopausal age could not be investigated.
We had no PNX occurrence.
We had @number@ non-expert judges identify virtual visual stimuli and three-dimensional scenarios , and five expert judges assisted with content analysis and developing instructions.
We had previously found that HA prolonged the lifespan , and prevented the cellular aging of murine adipose-derived stromal cells.
We had proposed new @number@ approaches of total pleural covering ( TPC ) and awake surgical intervention ( ASI ) for intractable pneumothorax.
We had proposed the techniques of surgical approaches for polysurgery of intractable SSP.
We have addressed this by exploring a peptidergic neuron R15 , an identified neuron of the marine snail Aplysia californica.
We have addressed this issue by measuring the @number@'-overhangs of a human tissue cells aging in vivo.
We have also briefly reviewed the literature on the use of injectable PLLA for volume restoration in the hand.
We have also demonstrated that high levels of β-amyloids corresponded to dysfunction among brain synapses.
We have also demonstrated that these correlations are tissue specific being reduced ( CASP9 and CASP10 ) or different ( CASP2 ) in the liver.
We have also developed a high performance liquid chromatography method to measure the resveratrol within the final product.
We have also discussed the relation between the structure and function of epigenetic-modifying polyphenols.
We have also previously reported that MGO mediates ER stress and apoptosis in cardiomyocytes.
We have analysed the fatty acid composition of frontal , temporal and parietal neocortex in @number@ normal and @number@ AD brains.
We have analyzed the effect of aging on the muscle expression of Mfn2 and the impact of Mfn2 ablation on muscle function.
We have analyzed the recruitment and retention dynamics of RECQL5 at laser-induced DNA double strand breaks ( DSBs ) relative to other human RecQ helicases.
We have analyzed whether the progression of amyloidosis differentially affects males and females along aging in AβPP / PS1 transgenic mice.
We have applied ModuleBlast to expression and interaction data from mouse , macaque and human to study immune response and aging.
We have assessed the dynamics of oligodendrocyte generation and myelination in the human brain.
We have assessed the relative contribution of age and fatness to BP regulation in a healthy population investigated by nurse practitioners.
We have been invited to imagine a future where the care for older people goes beyond the current paradigm.
We have chosen to examine transcripts expressed by the cellular , leukocyte compartment of blood.
We have compared the effects of different 12-week exercise programs on simple and choice reaction and movement times in persons @number@ to @number@ years old.
We have confirmed endogenous WRN interaction with endogenous RPS3 , a ribosomal protein with endonuclease activities involved in oxidative DNA damage recognition.
We have contacted the author of these studies , but have not yet received a reply.
We have continued and developed another approach that considers both programmed and stochastic concepts to be incorrect.
We have created the databank for the contents of antioxidants in @number@ food products , beverages , etc.
We have created this scale by summing together various scores linked to a selection of parameters according to which MRI images are analyzed.
We have demonstrated a supplemental avenue where-by resveratrol may promote health by maintaining and enhancing plasticity of the vasculature.
We have demonstrated that perceived age was a significant biomarker for carotid atherosclerosis in Japanese.
We have demonstrated that the DMH plays an important role in the regulation of mammalian aging and longevity.
We have described all senescent changes in the chorioretinal junction chronologically.
We have described @number@ site-specific procedural techniques and created a video containing anatomical renderings of each targeted viaduct accompanied by technique demonstrations.
We have designed an integrated information system which has been validated by physicians and nurses from the Geriatrics Service in terms of usability.
We have developed an animal model to study the ovarian ageing process during this subfertile period to understand the mechanisms responsible for reproductive senescence.
We have developed a new \ "drug \ " and approach that appear to be effective in reducing arterial age.
We have developed a pH gradient elution technique for enhanced phosphopeptide identification in conjunction with titanium dioxide chromatography.
We have developed a robust method to perform retinal vascular fractal analysis from digital retina images.
We have developed a safe procedure of genetic correction of epidermal stem cells isolated from XP patients.
We have developed a strategic five-phase roadmap to foster the clinical validation of biomarkers in Alzheimer's disease , adapted from the approach for cancer biomarkers.
We have developed quantitative mass spectrometry ( MS ) -based analytical strategies to analyze stable end products of protein oxidation.
We have developed the KR-TEL system by fusing killerred with the shelterin component TRF1 ( KR-TRF1 ) or other shelterin proteins.
We have developed the Prevention of Delirium Programme , a multicomponent delirium prevention intervention and implementation process.
We have discovered an unexpected regulatory relationship between these two types of stress responses.
We have discussed how primary care can be redesigned to tackle the challenge of NCDs in resource-constrained countries.
We have documented abnormalities in endochondral formation of the long and short tubular bones as well as round bones of the wrists and feet.
We have entered a new era in understanding degenerative aortic stenosis in elderly patients.
We have evaluated a very elderly obese male affected by severe symptomatic OSA , poor controlled nocturnal hypertension and insulin resistance.
We have evaluated a web-based PHR in multiple locations covering diverse population groups.
We have evaluated the administration of citicoline in geriatric patients following a protocol of intravenous study on improvement of individual performances.
We have evaluated the different influences of risk factors in elective and urgency operation.
We have evaluated the therapeutic effect of intramuscular Botulinum Toxin type A ( BTX-A ) injection on painful HV in a double-blind randomized controlled trial.
We have examined the premise that irisin produced during exercise may subserve further functions in the musculoskeletal system.
We have explored how older twins experience and describe themselves in relation to their co-twin.
We have focused our attention on elucidation of the unresolved mechanism of Aβ catabolism in the brain.
We have found a high percentage of MCI in our sample.
We have found biomarkers for the decrease in B cell function in aged mice and humans.
We have found diverse evolutional trajectories over the past three years , some expected , others somewhat unexpected.
We have found that band @number@ clustering is a feature of only this small fraction , amounting to ∼0.1% of total circulating erythrocytes.
We have found that glaucarubinone induces oxygen consumption and reduces body fat content of C. elegans.
We have found that other proteolytic systems compensate for CMA loss in young mice which helps to preserve proteostasis.
We have generated a physiologically relevant bacterial artificial chromosome ( BAC ) -based genomic DNA expression model to study PS1 gene expression and function.
We have identified a candidate gene for future studies investigating a possible functional link between the response to stress and alcohol reinforcement.
We have identified an FXR-regulated pathway upstream of a transcriptional repressor that controls multiple bile acid metabolism genes.
We have identified a population of remarkably small cells in explants from newborns ( day 0-10 ) .
We have identified common risk factors that predict mortality that may be useful in making clinical decisions among older people living in the community.
We have identified here that the incidence of RAS , BRAF , and EGFR mutations is low in cSCC.
We have identified important characteristics that may be helpful for determining optimal prevention strategies.
We have identified @number@ brothers with an expansion mutation in C9orf72 using Southern blotting that is undetectable using repeat-primed polymerase chain reaction.
We have included @number@ research subjects at baseline and estimated the prevalence of depressive disorders for those with children.
We have investigated age-related changes in iliac crest bone biopsy specimens from @number@ normal subjects , @number@ men and @number@ women , aged 18-90 years.
We have investigated the effects of resveratrol and polydatin on the in vitro production of IL-17 in a model of inflammation in vitro.
We have investigated the environmental and lifestyle factors associated with perceived facial ageing in Chinese women.
We have investigated the impact of testosterone on quality of life ( QoL ) in diabetic men with ED.
We have investigated the transcriptomic changes following mild-intensity endurance training in skeletal muscle of elderly men.
We have investigated whether dietary fat modifies the postprandial oxidative stress in adipose tissue of elderly people.
We have measured the levels of plasmatic Q10 and cholesterol in young and old individuals showing different degrees of physical activity.
We have now assessed whether the reduced cognition was accompanied by lasting EEG abnormalities.
We have now examined the relationship between major components of energy expenditure and the FI34 in participants of the Louisiana Healthy Aging Study.
We have now examined whether Shh signaling has a function in these neurons.
We have now investigated the capacity of these nanoparticles to reverse bone loss in aged mice , a model of human senile osteoporosis.
We have observed substantially shortened TL in the cells of patients at diagnosis compared to age-adjusted controls.
We have observed that the expression of @number@ non-coding RNAs ( @number@ microRNAs and @number@ snoRNAs ) changes progressively with chronological age.
We have obtained and fully characterized by immunologic and biochemical approaches , a polyclonal antibody that specifically recognizes the C-terminus of Aβx-34.
We have performed a cross-sectional study to characterize clinical and functional state of Polish centenarians , with a special focus on BP.
We have performed comprehensive lipid phenotyping in the Leiden Longevity Study ( LLS ) .
We have previously demonstrated its relationships with cognitive decline and cerebral gray matter volumes , suggesting its role as a biomarker of cognitive impairment.
We have previously demonstrated that aging reduces the compensatory vasodilator response during hypoxic exercise due to blunted nitric oxide ( NO ) signaling.
We have previously demonstrated that this aging process is closely associated with reduced 20S proteasomal activity , with down-regulation of rate-limiting catalytic β-subunits particularly evident.
We have previously described a novel p.Ala53Glu mutation in @number@ Finnish families.
We have previously developed a non-degradable superelastic nitinol mesh scaffold concept that can be used for heart valve tissue engineering applications.
We have previously documented various GM changes in posttubercular kyphotic.
We have previously found that dietary lipid adsorbent-montmorillonite ( DLA-M ) has an unexpected role in preventing obesity.
We have previously found that orally administrated royal jelly ( RJ ) restored tear secretion in a rat model of dry eye.
We have previously identified a novel anti-inflammatory senescent phenotype of EC.
We have previously identified aurin tricarboxylic and its oligomers as promising agents in this regard.
We have previously identified the contribution of elevated BACE1 activity to voltage-gated sodium channel Na ( v ) 1.1 density and neuronal function.
We have previously reported an inhibitory role of H2S in the L-type calcium channels in cardiomyocytes.
We have previously reported that faster vagal recovery from cognitive challenge is associated with better EF.
We have previously reported that minicolumn spacing of cells in human association cortex is selectively reduced in normal aging ( minicolumn thinning ) .
We have previously reported that the expression level of Gnaq in the mouse forebrain cortex was significantly decreased with age.
We have previously reported the relationship among pulse wave velocity , age , and blood pressure in hypertensive subjects.
We have previously shown that BMS-777607 induces chemoresistance in vitro by causing polyploidy , which hampers therapeutic efficacy.
We have previously shown that chroman-4-ones act as potent and selective inhibitors of SIRT2.
We have previously shown that experimental stroke pathophysiology differs between young adult and aged rats.
We have previously shown that oxidative stress promotes viral replication , and progeny virus induces oxidative stress in host cells.
We have previously shown that regulatory T cells ( Treg ) accumulate dramatically in aged animals and negatively impact the ability to control persistent infection.
We have previously shown that the alleles at rs2279590 differentially regulate clusterin ( CLU ) gene expression in lens capsule tissues.
We have previously shown that the chemical chaperone 4-phenylbutyrate ( 4-PBA ) promotes the maturation of ABCC6 mutants to the plasma membrane.
We have previously shown that these SNPs are associated with skipping of CD33 exon @number@ in brain mRNA.
We have previously shown that Wnt5A-mediated signaling can promote melanoma metastasis.
We have previously used an iterative experimental-theoretical approach to unravel the early insulin signaling events in primary human adipocytes.
We have proposed a link between telomere length and gene expression profiles , however this now needs to be further investigated.
We have proposed telomere attrition as a parsimonious way to explain these diverse effects of aging on oocyte function.
We have purified full length PICH and BEND3 and shown that they exhibit a functional biochemical interaction in vitro.
We have recently demonstrated distinct differences in the aging profiles of cells ( oral mucosal and patient-matched skin fibroblasts ) isolated from these tissues.
We have recently demonstrated that foreign vocabulary cues presented during sleep improve later recall of the associated translations.
We have recently demonstrated that tetrahydrobiopterin ( BH ( @number@ ) ) augments reflex vasoconstriction ( VC ) in aged skin.
We have recently developed high performance magnetic nanobeads.
We have recently identified COH1 as a Golgi-enriched scaffold protein that contributes to the structural maintenance and function of the Golgi complex.
We have recently identified SOD1 and FUS mutations as the most common causes in a consecutive series of @number@ familial ALS pedigrees in Japan.
We have recently shown that inducible nitric oxide synthase ( NOS2 ) S-nitrosates and activates arginase @number@ ( Arg1 ) leading to age-associated vascular dysfunction.
We have reported an APOA2-saturated fat interaction determining body mass index ( BMI ) and obesity in American populations.
We have reported that molecular hydrogen has potential as an effective antioxidant for medical applications [ Ohsawa et al. , Nat.
We have reported that the yeast homolog of PKM2 , Pyk1 phosphorylates H3T11 to regulate gene expression and oxidative stress resistance.
We have searched for dietary factors that prevent brain senescence using a mouse model of age-related neurodegeneration ( SAMP10 ) .
We have selected a synergistic combination and we have evaluated its effect on the biological and molecular mechanisms of cell death.
We have shown that LC degeneration in Ts65Dn mice leads to exaggerated memory loss and neuronal degeneration.
We have shown that loss of DJ-1 leads to mitochondrial phenotypes including reduced membrane potential , increased fragmentation and accumulation of autophagic markers.
We have shown that serum-deprivation of confluent RPE cells is associated with upregulation of cholesterol synthesis and accumulation of unesterified cholesterol ( UC ) .
We have shown that short alleles of this repeat are associated with AD.
We have shown that the effects of host age on the microarchitecture of the spleen significantly impair susceptibility to mouse-adapted prions after peripheral exposure.
We have shown that these mice support the replication of both HBV and all six major HCV genotypes.
We have studied a large Sicilian family where IgAN segregates with an AD transmission.
We have studied the DDR stimulated by ICLs , localized by laser photoactivation of immunotagged psoralens , in the nuclei of live cells.
We have studied the properties of the model with two longevity genes located on the same and on different chromosomes using simulated data sets.
We have successfully carried out a pilot study to test the feasibility and acceptability of implementation of the programme.
We have successfully recapitulated amyloid-β and tau pathology in a single 3D human neural cell culture system.
We have suggested that the health status of individuals can be represented by the number of health deficits that they accumulate during their life.
We have tested this hypothesis by comparing centenarian offspring with age-matched controls.
We have thus discovered that CHIP regulates p53-mediated trans-repression of BACE1 at both transcriptional and post-translational level.
We have thus identified and quantified a number of factors associated with younger appearance in Chinese women.
We have to be vigilant for syncope in patients taking donepezil , which is possibly related to QT prolongation and TdP.
We have tried to be brief in order to show the importance of using nuclear medicine in gerontology.
We have two arms , many muscles in each arm , and numerous neurons that contribute to their control.
We have uncovered a novel role for the mitochondrial sirtuin SIRT4 in the regulation of hepatic lipid metabolism during changes in nutrient availability.
We have uncovered a novel role of TRAF6 in regulation of skeletal muscle mass.
We have used a mouse model with liver-specific defective CMA to identify changes in proteostasis attributable to reduced CMA activity in this organ with age.
We have used DREADDs to stimulate degenerating neurons in a Down syndrome ( DS ) model , Ts65Dn mice.
We have used quantitative proteomics to characterize the phenotype of dermal fibroblasts from healthy subjects of various ages and from patients with SSc.
We have validated this method using mouse xenograft tumor models and confirmed its utility in human cancer patients.
We hereby report specific cases of colon cancer treatment policies for elderly patients at our hospital , together with a discussion of the literature.
We here demonstrate that post-thymic human T-cell differentiation was associated with the downregulation , but not loss , of the inhibitory molecule CD5.
We here discuss how the intricacies of mitochondrial homeostasis impinge on the intracellular propagation of mutant mtDNA.
We here discuss the hypothesis that the age-related loss of brown adipocyte regenerative capacity is a result of dysfunctional stem / progenitor cells.
We here elaborate on the roles of iron , copper , and zinc in AD and describe the therapeutic implications they present.
We , here , focused on the interaction between hNSCs and allogeneic peripheral blood mononuclear cells ( PBMCs ) in a co-culture model.
We here found that esculetin , @number@ , 7-dihydroxycoumarin , strongly induces type I procollagen expression in human dermal fibroblasts.
We here have analyzed the possibility that low-dose lithium exposure may affect mortality in both metazoans and mammals.
We here highlight the role of mitochondria in osteoclast function.
We here illustrate how system biology strategies for repositioning existing FDA-approved drugs may accelerate our therapeutic capacity to eliminate CSC traits in pre-invasive intraepithelial neoplasias.
We herein demonstrated that the expression of Sirtuin1 ( SIRT1 ) was decreased and the expression of SASP components was reciprocally increased during cellular senescence.
We herein describe a 37-year-old man who developed cervical flexion myelopathy @number@ years after suffering a cervical spinal cord injury.
We herein describe a strategy that targets membrane-bound KitL ( mbKitL ) via DNA vaccination.
We herein describe the age-dependent alterations observed in the various arms of the immune system.
We herein examined whether CSA is associated with alcohol intolerance in Japanese subjects.
We herein propose modifications to improve the performance of PRS.
We herein review WWOX's role that has been unearthed thus far in different types of malignancies , its clinical significance and future implications.
We herein sought to explore the role of miR-194 in the replicative senescence and stress-induced senescence of mouse embryonic fibroblasts.
We here overviewed the current evidence for the clinical feature and the mechanistic insight of glucose intolerance in the elderly.
We here provide a brief review of epigenetic drift , focusing on the potential implications for ageing , stem cell biology and disease risk prediction.
We here provide an overview of age-related changes in B cell markers and functions.
We here report a sequencing study of the AR CAG repeat in a cohort of SBMA patients and control subjects in the United Kingdom.
We here report synthesis for the first time of the acetyl salicylic acid dimer @number@'-methylenebis ( 2-acetoxybenzoic acid ) ( DAS ) .
We here show that the ability to generate a vaccine-specific antibody response is negatively correlated with levels of serum TNF-α.
We herewith present a family , which we studied at biochemical and molecular level , after identifying the proband through a newborn screening programme.
We highlighted the presence of unusual symptoms such as frontal executive syndrome , psychosis and spastic paraparesis in these patients.
We highlight how assistive products can be considered as both a mediator and a moderator of SDG achievement.
We highlight how peroxisomal metabolism may contribute to the bioavailability of important mediators of oxidative stress , with particular emphasis on reactive oxygen species.
We highlight key trends by World Health Organization sub-region , and identify gaps in existing knowledge.
We highlight recent findings that have been highly cited over the past five years.
We highlight some of the shared mechanisms between the ageing process itself and emerging pathogenic mechanisms in ALS / FTD.
We highlight some seminal features in nucleosome assembly conserved in mammalian systems and describe some of the lingering questions in the field.
We highlight the importance of considering baseline task ability when designing tDCS experiments , particularly in older adults.
We highlight the importance of considering body fat in gender-specific risk stratification in older adults with normal weight.
We highlight the inherent ability of communication theory to be blind to molecular and / or genetic mechanisms.
We hoped to identify mutations associated with delayed development and to compare each subject's biological and chronological ages.
We hope future research incorporates biological properties analysis of this HA dermal filler in clinical trials.
We hope our simple glabellar wrinkles classification enables a more accurate , individualized treatment with botulinum toxin in Asians.
We hope our study will contribute to the future development of this area.
We hope that all ASEAN citizens can enjoy higher health and safety standards , comprehensive social protection , and improved health status.
We hope that this critical analysis will initiate a debate on the Active Ageing Index that , in our view , is overdue.
We hope that this evidence map will provide a resource for researchers to direct new intervention studies and meta-analyses.
We hope to provide a more comprehensive approach to treating the aging face and skin that will provide patients with more long-lasting and youthful results.
We hope to use the EQ-5D with other health survey questionnaires to gather more data about HRQOL of Japanese people.
We hypothesised that age-associated changes in gait speed and kinetics are more pronounced during fast-speed walking and post-activity walking , compared with usual-speed walking.
We hypothesised that cannabis use is associated with subtle changes in gait and balance that are insufficient in magnitude for detection in a clinical setting.
We hypothesised that cerebrovascular reactivity is impaired with increasing age and in patients with symptomatic coronary artery disease ( CAD ) .
We hypothesised that the extent of HYP damage may determine severity of MS and may be associated with the disease evolution.
We hypothesise that an increase in valproate dosage unmasked clinically silent Parkinson's disease.
We hypothesize CSF ApoE4 increases risk of clinical progression through its association with CSF Tau in APOEε4 carriers.
We hypothesized a negative correlation between mindfulness disposition and perceived stress such that participants reporting higher levels of dispositional mindfulness would report lower stress.
We hypothesized common cellular origin and pathogenesis in small-cell carcinoma of esophagus and lung associated with SOX2 overexpression and loss of Rb1.
We hypothesized HF patients would exhibit less circadian variation with worsened cardiac function and sleep apnea.
We hypothesized inflammation increases when obesity and HIV infection co-occur.
We hypothesized pretrauma FIM scores may predict survival in the geriatric trauma population.
We hypothesized telomere length , a marker of cellular aging , would be longer in women who had 2-3 pregnancies.
We hypothesized that aberrant DNA methylation may affect circadian rhythms in AD.
We hypothesized that abnormal sleep transitions other than SOREMPs can be identified in type @number@ narcolepsy.
We hypothesized that age-related biochemical changes in bladder leading to altered bladder function will be reflected in altered urinary proteome of elderly OAB patients.
We hypothesized that age-related changes in LV myocardium are associated with telomere length.
We hypothesized that age stereotypes have increased in negativity due , in part , to the increasing medicalization of aging.
We hypothesized that aging could be a defining feature in the occurrence of rod-shaped microglia.
We hypothesized that aging could influence the APOE ϵ2 and ϵ4 allele effects that contribute to their appropriate AD risks differently.
We hypothesized that a higher SSI would indicate a more stable gait pattern and could be used to assess fall risk.
We hypothesized that AKT1 variants may play a role in the endophenotypes that makeup metabolic syndrome.
We hypothesized that among older women , weaker CARs would be associated with poorer cognitive function @number@ y later.
We hypothesized that analyzing tissues by matching on degree of disease severity would identify different patterns of gene expression from a traditional case-control comparison.
We hypothesized that aortic stiffening increases this previously ignored component of LV load and may contribute to hypertrophy.
We hypothesized that arterial stiffness gradient is less influenced by changes in MAP.
We hypothesized that atherosclerosis of the descending aorta ( DAo ) could be a risk marker for brain aging and injury.
We hypothesized that autonomic support of blood pressure is higher after menopause in women.
We hypothesized that catabolic ( anorexigenic and hypermetabolic ) CRF effects vary with aging similarly to those of melanocortins.
We hypothesized that chronic eczematous dermatitis in patients with neurodegenerative diseases may be an early marker of bullous pemphigoid.
We hypothesized that cigarette smoking induces extensive transcriptomic changes that lead to target-organ damage and smoking-related diseases.
We hypothesized that CIM may link CD to small bowel carcinogenesis.
We hypothesized that cognitive improvement would be maintained @number@ years after bariatric surgery.
We hypothesized that common genetic variations in / near SIM1 could exert more subtle effects on its function and associate with human adiposity.
We hypothesized that comprehensive national data on ICU resources would permit a better understanding of regional differences in system capacity.
We hypothesized that cross bridges are the pathways left by these receding blood vessels.
We hypothesized that damage to these tracts would be specific to nfvPPA and would correlate with differential aspects of the patients ' fluency abilities.
We hypothesized that delta EROs were affected by age-related changes , which could be reflected in a visual oddball paradigm.
We hypothesized that detectable asymmetry ( left > right ) exists in thalamocortical fiber connections and the connectivity increases with age during maturation.
We hypothesized that dietary protein intake and leisure-time physical activity are associated with LBM in community-dwelling older adults.
We hypothesized that djembe drumming constitutes low-to-moderate intensity exercise , and that drumming would simultaneously reduce stress and anxiety levels and benefit cardiovascular health.
We hypothesized that ECFC dysfunction in PT might result from premature senescence and investigated the underlying mechanisms.
We hypothesized that educational level would be an important factor for ToM in elderly participants , and especially in a non-Western country.
We hypothesized that elevated cortisol levels would be associated with poorer frontal-executive function in addition to episodic memory.
We hypothesized that elevated Neuroticism , lower Openness , and lower Conscientiousness would be independently associated with risk of AD.
We hypothesized that environmental factors would start to outweigh genetic factors during late childhood and adolescence.
We hypothesized that ET-1 upregulation may be a basis of enhanced collagen synthesis in the senescent fibroblasts resulting in cardiac fibrosis with aging.
We hypothesized that excessive planar division of undifferentiated germ cells promotes their self-renewal and TGCT development.
We hypothesized that exercise and isoflavone supplementation ( Ex + ISO ) could reduce inflammation in the same subpopulation of women.
We hypothesized that exposure to even a single unit of older RBCs may be associated with an increased risk of death.
We hypothesized that FD would better capture clinical features of the WM morphometry in different ALS phenotypes than VBM analysis.
We hypothesized that frailty determines the difference between the creatinine- and cystatin C-based formulae.
We hypothesized that gender differences would exist among factors associated with hypertension diagnosis and control among community-dwelling , older adults.
We hypothesized that greater co-contraction is associated with slower gait speed during dual task conditions that stress executive and attentional abilities.
We hypothesized that greater trial-to-trial variability in theta power during performance monitoring may be associated with greater behavioral variability in response latencies.
We hypothesized that growth- and age-related deficits in trabecular bone disrupt this frugally assembled microarchitecture , producing bone fragility.
We hypothesized that healthy bottlenose dolphins ( Tursiops truncatus ) @number@ years and older may demonstrate similar clinicopathological changes with increasing age.
We hypothesized that hemolysis could also occur due to intraventricular obstruction in patients with hypertrophic cardiomyopathy ( HCM ) .
We hypothesized that high concentrations of circulating biomarkers would be associated with lower functioning across study populations representing the adult life span.
We hypothesized that high CRF may be associated with reduced age-related carotid arterial remodeling.
We hypothesized that higher amyloid toxicity at later ages might cause the late onset of polyglutamine diseases.
We hypothesized that higher serum uric acid would be associated with poorer concurrent functioning and greater declines over @number@ years.
We hypothesized that if stroke as a cerebrovascular event causes depression , this so-called post-stroke depression will further increase the risk of recurrent stroke.
We hypothesized that impaired fasting glucose ( IFG ) and incident glucose disorders have detrimental effects on global cognition and brain volume.
We hypothesized that improved air quality in North Carolina was associated with reduced rates of death from respiratory diseases in local populations.
We hypothesized that increased HIF-mediated gene transcription by VHL deletion in the β-cells would increase β-cell mass and function.
We hypothesized that individuals with greater carotid intima-media thickness ( cIMT ) and carotid plaque burden would exhibit worse cognition.
We hypothesized that individuals with higher amounts of reserve would be able to tolerate greater amounts of pathology than those with lower reserve.
We hypothesized that inflammatory state and higher CVR in CS might be related to TL shortening , as observed in premature aging.
We hypothesized that influenza vaccine responses may be enhanced with meditation or exercise training as compared with controls.
We hypothesized that in older adults whole-body cooling would elicit a blunted SSNA response and cutaneous adrenergic responsiveness would be reduced.
We hypothesized that involvement in conservative treatments ( ablation and / or active surveillance ) occurs infrequently.
We hypothesized that IPV exposure would be associated with shorter telomere length.
We hypothesized that Klotho is involved.
We hypothesized that late-onset RRTI is caused by mild immunodeficiencies , such as SPAD , that remain hidden through adult life.
We hypothesized that localized BH ( @number@ ) supplementation would not affect the VC response to exogenous NE when sympathetic nerves were blocked.
We hypothesized that loneliness among persons aged 70-90 years is associated with subsequent decline in health , function , and longevity.
We hypothesized that loneliness might occur in association with elevated cortical amyloid burden , an in vivo research biomarker of AD.
We hypothesized that lower optimism would be associated with greater social disadvantage and poorer social mobility.
We hypothesized that low levels of B12 would be associated with albuminuria in a population-based cohort.
We hypothesized that low serum 25 ( OH ) D levels predicted mortality in older adults.
We hypothesized that LRRK2-susceptible allele ( s ) for PD might pose a risk for Alzheimer's disease ( AD ) .
We hypothesized that magnesium sulfate would potentiate the effect of DigiFab in the reversal of CTS-induced Na / K-ATPase inhibition.
We hypothesized that modification of gait due to aging may be related to changes in frontal lobe function.
We hypothesized that modifications in erlotinib pharmacokinetics might explain this observation.
We hypothesized that MSC from older donors may display differences in cellular fitness when expanded for clinical use.
We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls.
We hypothesized that network alterations are detectable already in preclinical AD and investigated major global WM network properties.
We hypothesized that NO metabolism would be attenuated in fetal plasma due to low Cp activity.
We hypothesized that NQO2 hepatic drug clearance would develop in children over time , similar to NQO1.
We hypothesized that older adults are perceived to have lower social status because they are less likely to be seen in prestigious occupational positions.
We hypothesized that older adults will exhibit greater EFL and increases in EELV during exercise compared to younger controls.
We hypothesized that older adults would adapt to the novel dynamics less well than young adults.
We hypothesized that older adults would decrease force output at a faster rate than younger adults , due to age-related deficits in working memory.
We hypothesized that older adults would take longer than younger adults to recover from an unexpected perturbation during gait especially when walking faster.
We hypothesized that older patients with hip fracture who received our interdisciplinary intervention program would have better HRQOL than those who did not.
We hypothesized that older people who engaged in more SOC talk would have higher well-being.
We hypothesized that ongoing derangement of skeletal muscle cytoarchitecture at the single fiber level may precede and be responsible for the progressive muscle weakness.
We hypothesized that OP would diminish postprandial glycemic responses to a high carbohydrate / fat breakfast and lunch.
We hypothesized that oral sapropterin ( Kuvan , a pharmaceutical BH4 ) would augment vasoconstriction elicited by whole-body cooling and tyramine perfusion in aged skin.
We hypothesized that OSA would have more prevalence in patients of a wound center than the general middle-aged population.
We hypothesized that our training system could increase physical fitness in older people.
We hypothesized that oxidative posttranslational modification of parkin by environmental toxins may contribute to sporadic PD.
We hypothesized that PARP-1 plays a role in accelerated aging in chronic inflammatory diseases due to its role as coactivator of NF-κb and AP-1.
We hypothesized that persistent pain would predict accelerated memory decline and increased probability of dementia.
We hypothesized that PI3K / Akt / GSK-3β signaling pathway could be involved in this apparent age-dependent neuroprotective / neurodegenerative status.
We hypothesized that PKP2 variants that reduce INa could yield a BrS phenotype , even without overt structural features characteristic of arrhythmogenic right ventricular cardiomyopathy.
We hypothesized that plasma of an early developmental stage , namely umbilical cord plasma , provides a reservoir of such plasticity-promoting proteins.
We hypothesized that poorer sleep would be related to relatively more impaired cognition.
We hypothesized that preadipocyte factor-1 ( pref-1 ) concentration is altered in fetuses born to women with gestational diabetes mellitus ( GDM ) .
We hypothesized that rare APOE variants with large individual effects might also contribute to long-term good health.
We hypothesized that repeated mild inflammation may cause the connective tissue alterations in photoaging.
We hypothesized that resistance to type I collagen proteolysis not only marks biological aging but also drives it.
We hypothesized that resting state brain oscillations will show unique deficits within language network in each variant of primary progressive aphasia.
We hypothesized that sarcopenia , as measured by preoperative computerized tomography ( CT ) scan , predicts mortality and morbidity in emergent laparotomy.
We hypothesized that self-reported walking speed might be a good marker of objectively measured walking speed for use in this context.
We hypothesized that serum anti-Müllerian hormone ( AMH ) levels will be lower in premenopausal women with AITD than controls.
We hypothesized that slow breathing and vasomotion may correlate temporally ( \ "coupling \ " ) , especially at low oxygenation levels.
We hypothesized that sodium nitroprusside ( SNP ) can acutely ameliorate the age-associated deficits in E ( A ) / E ( LV ) .
We hypothesized that some age-related changes in gene expression are accelerated in AD patients.
We hypothesized that stressful life events could increase cortisol secretion leading to cognitive impairment.
We hypothesized that structural remodeling associated with advancing age occurs in human saphenous veins.
We hypothesized that substance use and a history of traumatic brain injury would be associated with cognitive impairment.
We hypothesized that testosterone treatment improves constitutional and sexual symptoms over and above the effects of weight loss alone.
We hypothesized that the accuracy ( sensitivity and specificity ) of informant reports would vary with the patient's personality.
We hypothesized that the association of demanding body postures with deteriorated self-rated health ( SRH ) is stronger among older employees than among younger employees.
We hypothesized that the chronic and persistent inflammation and immune activation associated with HIV disease leads to accelerated aging , characterized by CVD.
We hypothesized that the discrepancy between self-report and observed daily functioning would be modified by cognitive status.
We hypothesized that the duration of delirium in the ICU would be associated with subsequent disability and worse physical health status following a critical illness.
We hypothesized that the increased replicative potential of oral mucosal fibroblasts may confer upon them preferential wound-healing capacities.
We hypothesized that the local production of collagen is associated with the level of GH / IGF1.
We hypothesized that the number of cardiovascular risk factors determines the progression of vascular aging.
We hypothesized that the positive impact of social engagement within the facility would be greater among residents with higher levels of functional disability.
We hypothesized that there are differences in the decision-making process for young and old patients.
We hypothesized that there are major developmental differences in plasma proteins and that these contribute to age-related changes in the incidence of major diseases.
We hypothesized that the rs8192678 PGC-1α single nucleotide polymorphism ( SNP ) may influence risk or age of onset of PD.
We hypothesized that these factors would negatively influence neurobiological , neuropsychological and sensory development later in life.
We hypothesized that these @number@ syndromes are part of a single clinical and biologic continuum.
We hypothesized that the spiral axis , described below , is a useful screening tool to distinguish ET cases from dystonia cases.
We hypothesized that this growth-limiting genetic program is orchestrated by microRNAs ( miRNAs ) .
We hypothesized that variants in the sortilin-like receptor ( SORL1 ) gene would affect multiple Alzheimer's phenotypes before the clinical onset of symptoms.
We hypothesized that vegetable peptones promote cell proliferation and production of type I collagen in human dermal fibroblasts.
We hypothesized that vessels of females express more dilatory β-adrenoceptors , which counteract constrictive effects of α-adrenoceptors.
We hypothesized that vit-D deficiency in patients with T2DM may contribute to left ventricular ( LV ) dysfunction.
We hypothesized that voluntary aerobic exercise would increase arterial resilience in old mice.
We hypothesized that VR may be applied to address the multifaceted deficits associated with fall risk in PD.
We hypothesize that , after additional studies , this technology also may be a useful tool to aid in diagnosing skin diseases.
We hypothesize that age-related skeletal muscle dysfunction and physical disability may be partially explained by alterations in the function of the myosin molecule.
We hypothesize that aging can be inhibited or even arrested when full mobilization of all resources is needed for the survival of an individual.
We hypothesize that an intervention that combines muscle coordination and reduced visual feedback would be advantageous to improve motor control in older adults.
We hypothesize that anthracyclines may induce both INaL hyperactivation and an oxidative / energetic vicious cycle in cardiomyocytes.
We hypothesize that atorvastatin is effective in reducing CSDH and have tested the hypothesis in a preliminary prospective study of small cohort of patients.
We hypothesize that brain reserve may have neuroprotective effects against late life depression.
We hypothesize that combining the findings from different AD GWAS may have greater power than genetic analysis alone.
We hypothesize that down-regulation of PPARγ is linked to neuroinflammation and the subsequent cognitive deficits observed in an animal model of POCD.
We hypothesize that dynamic movement of cav-1 is essential for physiological contractile response of colonic smooth muscle.
We hypothesize that genetic modifiers may explain this variability of symptoms.
We hypothesize that greater TL at baseline would predict a better response to a weight loss treatment.
We hypothesize that ILC2s are required and sufficient for development of the asthmalike phenotype in immature mice.
We hypothesize that midfacial deep filler injections also may activate subdermal white adipose tissue stem cells contributing to longer lasting rejuvenation.
We hypothesize that obesity creates a low-grade inflammatory microenvironment , which stimulates Wnt-signaling and thereby promotes the development of breast cancer.
We hypothesize that older age will additionally impact operative morbidity after CRC resections in a multihospital , risk-adjusted database.
We hypothesize that Olympians , both women and men , have lower mortality rates.
We hypothesize that OSA , independent of obesity , contributes to abnormal vascular function.
We hypothesize that oxygen users in the current era may be very different.
We hypothesize that oxysterols could be implicated in either apoptosis or pyroptosis , or both.
We hypothesize that patient demographic factors assessable by the clinician at fracture presentation can predict nonunion.
We hypothesize that Pin1 might help explain an inverse relationship between Alzheimer's disease and cancer.
We hypothesize that quantitative and qualitative sarcopenia-related parameters may not be equally predictive of incident disability , thus presenting different clinical relevance.
We hypothesize that reduced functional integration of the LC reflected by lower brain functional connectivity contributes to early memory dysfunction.
We hypothesize that semi-volatile PCBs , like those found in inner city air , are capable of disrupting telomerase activity and altering telomere length.
We hypothesize that SLT-VEGF could be a promising adjuvant therapy to inhibit or prevent outgrowth of metastatic foci after excision of aggressive primary melanoma lesions.
We hypothesize that smoking may cause cellular mitochondrial dysfunction and oxidative stress , leading to aging acceleration.
We hypothesize that some women are particularly sensitive to hormonal changes occurring across their reproductive lifespan.
We hypothesize that the lack of effective interventions is due , in large part , to an overemphasis on pharmacotherapy and direct chondral repair.
We hypothesize that this \ "carry-over \ " effect might be the result of transcription regulation in embryos.
We hypothesize that this decline may be an early manifestation of an accelerated cognitive aging process.
We hypothesize that this delayed phenotype can be explained by increased GAG sulfation over time.
We hypothesize that this long-term programming effect is via a resetting of pituitary control in response to raised levels of IGF-I in childhood.
We hypothesize that this might facilitate tumour development.
We hypothesize that VP2 , a major capsid protein of H-1 virus , determines H-1-specific tropism.
We hypothesize utility to further exploring the impact that new health care delivery models will have on health systems ' IT infrastructures.
Weibull analysis was used to evaluate the strength reliability.
Weibull parameters ( modulus and characteristic strength ) also were calculated for each group.
Weibull statistics revealed @number@ fracture mechanisms in Y-TZP milled in fully sintered condition.
We identified a common haplotype associated with PGRN Thr272fs carriers , assuming common ancestry.
We identified age-adjusted frailty prevalence by geographical region.
We identified a genetic pathway that modulates aging-related LRO phenotypes via serotonin signaling and the gene kat-1 , which encodes a mitochondrial ketothiolase.
We identified a genome-wide significant association between the Excitement-Seeking scale and rs7600563 ( P = 2 × 10 ( @number@ ) ) .
We identified a gradual upregulation of four miRNAs : miR-455-3p , miR-4668-5p , miR-3613-3p and miR-4674.
We identified a heterozygous missense mutation in MET proto-oncogene , p.Asn375Lys , in all four affected siblings.
We identified all persons with MCI and ET in a dementia-free , population-based study in central Spain ( NEDICES ) .
We identified alterations in lysoPCs , amides , and cis-4-octenedioic acid among non-diabetic and non-obese individuals with borderline-to-moderate HTG.
We identified an androgen-dependent lncRNA , POTEF-AS1 , whose expression was regulated by androgen receptor in two androgen-dependent cells by using directional RNA sequencing analysis.
We identified and replicated trans eQTLs for @number@ SNPs ( reflecting @number@ independent loci ) that were previously associated with complex traits at genome-wide significance.
We identified a novel disease-causing ( deletion ) mutation in the COL18A1 gene leading to a frameshift and premature stop codon in the last exon.
We identified a novel , rare SMPD1 variant ( p.R591C ) which increased the risk of PD ( p = @number@ ) .
We identified a number of healthy-cognitive-aging candidate genetic loci awaiting confirmation in larger studies.
We identified APTs to directly interact with CD95 to promote depalmitoylation , thus impairing apoptosis mediated through CD95.
We identified a single polymorphism that is coinherited with rs3865444 , i.e. , rs12459419 in exon @number@
We identified associations in the correlation analysis of age , cerebral GM volume , years of education , and the personality trait of openness.
We identified a subtle diffuse decreased T1 and T2 bone marrow signal , not corresponding to sclerosis on CT or radiographs , in two cases.
We identified a total of @number@ differentially expressed proteins , including alphaB-crystallin ( Cryab ) .
We identified a total of @number@ therapeutic conflicts in @percent@ of the of the study population.
We identified a whole-brain significant age-related decline of ventral striatum activation during reward anticipation as compared to neutral anticipation.
We identified by mass spectrometry @number@ nuclear proteins that complexed with WRN.
We identified damage-regulated autophagy modulator ( DRAM ) as one of the genes that were more upregulated by S121F than wild-type p53.
We identified DHHC-12 as the principal palmitoyl acyltransferase that palmitoylates gephyrin.
We identified diabetes patients by means of three nationwide Danish health registers.
We identified differences in smoking characteristics and prevalence rates of DSM- @date@ -month diagnoses by smoking severity.
We identified eight publications for CV disease risk , which provided @number@ female and @number@ male effect size ( ES ) observations.
We identified five genome-wide significant loci ( < 10 ( @number@ ) ) .
We identified four functional domains ( ocular motor dysfunction , postural instability , akinesia , and cognitive dysfunction ) as clinical predictors of PSP.
We identified genes previously unknown to be involved in CAG- / polyQ-related pathogenesis that function in multiple DNA damage repair systems.
We identified histone deacetylase @number@ ( HDAC9 ) and RPTOR-independent companion of MTOR complex @number@ ( RICTOR ) as the direct targets of miR-188.
We identified key thresholds of physical functioning items in an item bank to facilitate clinical and epidemiologic decision-making.
We identified lysines ( K ) @number@ and @number@ as the major Sumo1 conjugation sites in Prdx6.
We identified mutations in over @percent@ of cases , and PDCD10 / CCM3 accounts for @percent@.
We identified new markers of aging in β cells , including IGF1R.
We identified no evidence suggestive of significant association with occupational exposures.
We identified novel loci associated with airway responsiveness in a GWAS among smokers with COPD.
We identified @number@ articles meeting our search criteria.
We identified @number@ cardiac surgical operations.
We identified @number@ cases of single amino acid substitutions.
We identified @number@ compounds that increase longevity in C. elegans , @number@ of which also increased resistance to oxidative stress.
We identified @number@ CpG sites , mapping to @number@ genes , associated with age , with @number@ sites previously associated with age.
We identified @number@ eligible studies ; all were cross-sectional ; few examined multiple brain areas.
We identified @number@ expression quantitative trait loci ( eQTLs ) and @number@ splicing quantitative trait loci ( sQTLs ) , including @number@ new QTLs.
We identified @number@ genes that were differentially expressed in relation to BP ( Bonferroni-corrected p < 0.05 ) .
We identified @number@ genes whose liver expression also correlated with age.
We identified @number@ heteroplasmies ( with an alternative allele frequency of at least @percent@ ) at @number@ positions across the mtDNA genome.
We identified @number@ heterozygous missense mutation , p.Ala72Thr ( c.214G > A ) , in @number@ patient with bulbar-onset and apparently sporadic ALS.
We identified @number@ HIV patients that underwent @number@ primary hip and one primary knee arthroplasty between @date@ and @date@ .
We identified @number@ hospitalizations of patients with chronic pain and analyzed their combinations of chronic conditions ( multimorbidity ) .
We identified @number@ loci that surpassed the threshold for genome-wide significance ( p < 5×10 ( @number@ ) ) .
We identified @number@ LOPAC compounds , nine kinase inhibitors and one kinase activator which induced RBC shrinkage and vesiculation.
We identified @number@ missense and nonsense mutations in TREM2 exon @number@ in @number@ subjects.
We identified @number@ mutations in COL7A1 , of which nine are novel.
We identified @number@ new genetic loci that exceeded genome-wide significance , implicating genes involved in cardiac electrical and structural remodeling.
We identified @number@ novel mutations in p62 / SQSTM1 in @number@ patients.
We identified @number@ @number@ male patients who were newly diagnosed with IBS from @number@ to @number@
We identified @number@ OSA and @number@ non-OSA subjects who underwent polysomnography evaluation.
We identified @number@ papers in the initial search , and included @number@ in this systematic review.
We identified @number@ participants with some form of elder abuse reported to a social services agency.
We identified @number@ patients reported with chronic lymphocytic leukemia to the registry between @number@ and @number@
We identified @number@ patients who had taken , in total , @number@ antipsychotic or antidepressant drugs.
We identified @number@ ( @percent@ ) out of @number@ patients taking PIMs.
We identified @number@ potential drug-drug interactions , with @percent@ classified between analgesics ( without coanalgesics ) .
We identified @number@ potential predictor variables and used the Quality of Life Index ( QLI ) to assess QOL.
We identified @number@ published studies.
We identified @number@ scales in @number@ included publications.
We identified @number@ studies including @number@ @number@ subjects.
We identified @number@ studies , which examined a total of @number@ brain volumetric measures.
We identified @number@ subjects that had pathological AD , a non-amnestic presentation ( i.e. atypical AD ) , and MRI.
We identified @number@ trials , and after an assessment of relevance , five trials with a combined total of @number@ participants were analyzed.
We identified @number@ types of collagen-derived peptides transiently , with a particular enrichment in Gly-Pro-Hyp.
We identified @number@ variants at @number@ loci that reached chip-wide significance , including @number@ novel loci and @number@ East Asian-specific coding variant associations.
We identified @number@ variants ( @number@ novel ) , including @number@ missense substitutions , @number@ synonymous , and @number@ intronic alterations.
We identified numerous such colocated boundary and enhancer elements from human CD4 ( + ) T cells.
We identified only one age-related gene common to the three tissues.
We identified PLHIV using a validated algorithm.
We identified predictors for HR of patients aged > 85 years admitted to the ICU after surgery.
We identified protein oxidation in ECs exposed to hypoxia and in all cell types exposed to oxidative stress.
We identified quantitative facial features , such as eye slopes , highly associated with age.
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of @number@ subjects.
We identified RE in @number@ ALS-plus individuals ( @percent@ ) displaying PSP and CBS features.
We identified seven loci for erythrocyte traits including a locus ( RBPMS / GTF2E2 ) associated with mean corpuscular hemoglobin and mean corpuscular volume.
We identified several candidate genes , but further investigation is required to determine the role of these genes in PD.
We identified several genes whose deletion led to significant changes of chronological lifespan in yeast , featuring both lifespan shortening and lifespan extension.
We identified six additional signals using 1000G imputation , while @number@ loci were associated using both HapMap and 1000G imputation.
We identified specific proteins that have implications in cancer progression and metastasis that are differentially regulated by restriction of either glucose or serum.
We identified statistically significant interactions between the APOA2 -265T > C and saturated fat regarding BMI in all @number@ populations.
We identified subgroups of putative SUMO2 targets that were either degraded or stabilized by EPOX upon SUMO2 conjugation in response to replication stress.
We identified subjects who reported being a caregiver at T2 and starting care after T1 ( mean age = @number@ @percent@ female ) .
We identified sub-pathways , important hub proteins , and evolutionary conserved interactions.
We identified tau and its phosphorylated forms as potential PrP-interactors and report a novel protective function of PrP ( C ) in AD-like tau pathology.
We identified the major fermented metabolite in the FO as ferulic acid.
We identified the most significant time during the day that is associated with daily mortality.
We identified the VAN independently for both groups using spatial independent component analysis.
We identified three central themes common to the participants ' stories : uncertainty , stigma , and resilience.
We identified two association peaks that exceeded genome-wide significance.
We identified two quadrivalent-vaccine studies and eight bivalent-vaccine studies conducted in Asian countries.
We identified variants of the MET gene in three pRCC1.
We identified YME1L1 , a human homolog of yeast YME1 ( yeast mitochondrial DNA escape @number@ ) to be frequently mutated in colorectal tumors.
We identify age , education , and multilingualism as the most important factors influencing vocabulary size.
We identify an age-related depletion of a subpopulation of MSCs characterized by a pro-vascular transcriptional profile.
We identify a number of discursive practices applied in various research projects that present a one-sided story of old age in Japan.
We identify characteristics of parents with child-related educational debt among the late baby boom cohort.
We identify CpG loci that show a highly significant , consistent correlation between DNA methylation and chronological age.
We identify Epm2aip1 as a GS-associated protein.
We identify factors nurses refer to when describing these decisions , situated within contextual features of nursing practice.
We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus.
We identify four themes.
We identify genetic risk profiles based on GWAS variants associated with schizophrenia and Crohn's disease as significantly associated with risk of PD.
We identify here the proteins most vulnerable to aggregation as those whose cellular concentrations are high relative to their solubilities.
We identify metrics to define optimal brain health in adults based on inclusion of factors that could be measured , monitored , and modified.
We identify nuclear respiratory factor @number@ and peroxisome proliferator-activated receptor γ coactivator 1α as regulators of human telomere transcription.
We identify @number@ and @number@ RBPs to be significantly associated with age and gender respectively.
We identify several methodological shortcomings , and describe the clinical implications of this review for the development of preventive intervention strategies.
We identify the strengths and barriers hindering the full operation , and we proposed a technological solution that overcame these constraints and facilitated integration.
We identify three core processes of livability including enacting an ideology of aging , building social infrastructure , and negotiating daily participation.
We identify two acetylation sites on DBC1 that regulate its ability to bind SIRT1 and suppress its activity.
We identify YME1L1 as the first NUMT suppressor gene in human and demonstrate that inactivation of YME1L1 induces migration of mtDNA to the nuclear genome.
Weight and BMI of peripubertal and adult age groups increased from @number@ to @number@
Weight and height had some effect on straw drinking speeds.
Weight and height were measured , and body mass index ( BMI ) was calculated.
Weight and height were measured , and overweight / obesity was defined as a body mass index ≥25 kg / m ( @number@ ) .
Weight and height were measured at two time points , one in @date@ and another in @date@ .
Weight , as opposed to REM-AHI and NREM-AHI , was related to changes in HbA1c.
Weight-bearing exercise has several benefit , including improved blood and synovial fluid circulation in a given joint.
Weight-bearing exercise in youth affects bone , and these effects may be preserved as BMC , geometric and structural advantages even after @number@ years.
Weight-bearing full-length anteroposterior radiographs of the entire lower extremities were taken in a standing position.
Weight , BMI and percent body fat were reduced by @percent@ , @percent@ and @percent@ respectively in the FCR group.
Weighted analysis was conducted to compare the patients within the two care models in terms of functional , cognitive , and psychological factors.
Weighted Cox proportional hazard regression models were used to calculate relative risks ( RR ) and @percent@ CI.
Weighted estimates of frailty prevalence were obtained.
Weighted logistic regression analyses were performed.
Weighted values estimated levels in the older U.S. population.
Weight gain accompanied by an increased tendency for central fat distribution is common among women in midlife.
Weight gain after ART initiation was associated with lower mortality among underweight and normal-weight patients.
Weight gain after ART is associated with lower mortality for those who are not initially overweight.
Weight gain and accompanying fat deposition may accelerate age-related declines in respiratory function.
Weight gain during treatment was associated with being overweight / obese @number@ years post-treatment ( OR = @number@ @percent@ CI : @date@ @number@ ) .
Weight gain , increased food intake and better tolerance to chemotherapy have also been reported.
Weight gain in the control group was steady at a lower rate.
Weighting items in frailty scales can improve their predictive ability , but the trade-off between specificity , predictive power , and generalizability requires additional evaluation.
Weight , lean mass and BMI were positively related to WB , L2-L4 , FN and @date@ radius BMD.
Weightlifting showed the fastest and greatest decline with increasing age.
Weight loss did not account for the observed effects.
Weight loss due to medical or social reasons was often regained in subsequent @number@ years while weight loss due to other causes was not.
Weight loss interventions can effectively lead to improved physical function.
Weight loss interventions were all lifestyle-based.
Weight loss is a major component of frailty.
Weight loss is prevalent in the elderly population , with deleterious health consequences , notably loss of lean body mass and subsequent functional decline.
Weight loss of senescence is called anorexia of ageing.
Weight loss through an energy-restricted diet together with increased energy expenditure through physical activity contribute to the prevention and treatment of MetS.
Weight loss , underweight late-life BMI , and any BMI reduction were all associated with increased long-term mortality in the overall sample.
Weight loss was evaluated by analyzing the percentage of patients reaching at least a @percent@ weight loss from baseline after @number@ months of treatment.
Weight loss was most visible in men retiring from sedentary jobs and weight gain in women retiring from diverse and physically heavy jobs.
Weight loss was the only independent predictor of death.
Weight management interventions for this population should take a multifaceted approach.
Weight monitoring and appearance-altering behaviors did not differ between groups.
Weight stability ( @number@ @percent@ ) was more common than weight loss ( @number@ @percent@ ) or gain ( @number@ @percent@ ) .
Weight was ascertained at each examination to examine the effect of weight loss over follow-up.
We illustrate how these attitudes reveal broader contemporary values , discourses , and discomforts with menopause , aging , and biomedicine.
We illustrate the application of the Bayesian MI method using longitudinal data collected from the Lifestyle Interventions for Elders ( LIFE ) study.
We illustrate the proposed method in the context of a recently published analysis on transcriptomic profiling performed in blood.
We illustrate the proposed method with an example from cardiac surgery.
We illustrate the rationale and evaluate the performance of the proposed model through two GWAS.
We illustrate with examples from our own research on obesity and smoking.
We implemented a theory-driven program to improve care for falls at our Veterans Affairs healthcare facility.
We implemented the methods in an open-source R-based software package MSstatsQC and its web-based graphical user interface.
We implemented these algorithms with the automatic scanning system into an apparatus : a Mitsubishi Electric's MELFA RV-1 six axis manipulator.
We improved upon early procedures by grafting back fresh tissues using a simplified protocol.
We included age and gender and evaluated a two-way interaction term between gender and death circumstances.
We included approximately @number@ cohort members with information on depressive symptoms or frequency of physical activity at @number@ @number@ @number@ or @number@ years of age.
We included congenital heart patients of all ages having cardiac surgical operations.
We included consecutive cases for 1972-1975 , @number@ @number@ @number@ @number@ and 2000-2006.
We included cross-sectional population based studies providing numerical estimates on the prevalence of asthma.
We included eligible articles and estimated risk ratio ( RR ) with @number@ % confidence intervals ( @number@ % CIs ) .
We included every study presenting the MMSE scores in schizophrenic patients along with a corresponding mean age.
We included in this analysis all patients for whom data on drug use was available.
We included @number@ adults aged ≥ @number@ years with complete dietary data in at least three examinations from @number@ to @number@
We included @number@ adult subjects who did not report diabetes were included.
We included @number@ Atherosclerosis Risk in Communities Study participants who were free of AF at baseline.
We included @number@ case subjects with newly diagnosed diabetes and @number@ individually matched control subjects free of diabetes identified during a mean 5-year follow-up.
We included @number@ clinical trials.
We included @number@ critically ill adult patients receiving at least one unit of RBCs.
We included @number@ eligible cases in this study.
We included @number@ females and @number@ males with a mean age of 87±4years.
We included @number@ individuals @number@ years or older diagnosed with incident lung cancer from @number@ to @number@
We included @number@ live-born Danish twins from @number@ to @number@ identified through the Danish Twin Registry and performed piecewise stratified Cox regression and log-binomial regression.
We included @number@ men and @number@ women aged 40-79 years at baseline.
We included @number@ @number@ hypertensive patients , aged ≥55 years at the time of study entry.
We included @number@ offenders , of whom @percent@ were aging.
We included @number@ participants and administered the TMT ( TMT-A and TMT-B ) and the Wechsler Intelligence Adult Scale ( WAIS ) .
We included @number@ participants in a 2-year longitudinal study with baseline CSF measures and @number@ magnetic resonance images.
We included @number@ participants with pharmacy dispensing records.
We included @number@ patients and @number@ age- and sex-matched control subjects.
We included @number@ patients with hyperprolactinemic pituitary macroadenomas.
We included @number@ patients with sporadic FTLD-TDP , type A , B , or C , from @number@ consecutively autopsied patients with TDP-43 proteinopathy.
We included @number@ ( @percent@ ) patients who were healthy and well-functioning patients , of whom @number@ ( @percent@ ) were classified as older.
We included @number@ smokers older than 18years old , who reported no intention to quit smoking , whatever they were visiting general practitioners for.
We included @number@ studies from @number@ of @number@ EU and EEA countries.
We included @number@ studies ( two systematic reviews , @number@ quantitative studies , @number@ qualitative studies , and five mixed methods studies ) .
We included @number@ subjects ( @number@ diabetics , @number@ hypertensive patients , @number@ controls ) .
We included @number@ subjects who were cognitively normal from baseline through their last assessment before death and who underwent autopsy.
We included @number@ women enrolled in the Norwegian Mother and Child Cohort Study who reported pelvic girdle pain in pregnancy week @number@
We included only patients with first-ever ischaemic stroke who were testable for depression and executive dysfunction.
We included only TLE patients in which both recordings showed IED.
We included outpatients with type @number@ diabetes mellitus.
We included patients aged @number@ years and older who had an ED fall visit in @number@
We included patients in the CSR who had a GA and complete blood count test before initiation of therapy.
We included patients with an ejection fraction ≤35% who received ( ICD Registry ) and who did not receive ( GWTG-HF ) an ICD.
We included prospective cohort studies and retrospective case-control studies.
We included randomized controlled trials , clinical controlled trials , and prospective clinical studies to provide available data.
We included randomized controlled trials ( RCTs ) and non-RCTs which compared PEG with NG feeding in individuals with non-stroke dysphagia.
We included RCTs targeting children with ASD @number@ years old or younger.
We included revised HCA ACT items in the questionnaires for the other provider groups.
We included studies reporting on circulating microRNAs associated with exercise , diet , and weight loss in humans.
We included the last clinical observation for each patient from @date@ to @date@ .
We include evidence showing that the balance of factors contributing to normal blood pressure in young people is influenced by sex.
We include new data showing that theta-burst stimulation is more efficient than other forms of stimulation for LTP induction.
We incorporated age group and year of diagnosis into the model to estimate these indices for the period of 1973-2010.
We increased A152T clearance kinetics by both pharmacological and genetic upregulation of autophagy and ameliorated the disease pathology observed in A152T-tau fish.
We increased the cholesterol content of the clots by adding cholesterin to the blood.
We inferred NAT2 phenotype based on polymorphism at rs1495741 , highly predictive of enzyme activity.
We inferred that all these genes might play important roles in response to osmotic stimuli and age in IVD cells.
We inoculated mice s.c. with DISS and SKOV-3 , two representative human ovarian serous adenocarcinoma cell lines.
We inquired whether sling training is better than traditional physiotherapy in relieving pain and improving abilities of daily living.
We installed this system into the bronchoscopy room and have experienced its benefit.
We integrated PaATG8 interaction partners identified in an own yeast two-hybrid analysis using ATG8 of P. anserina as bait.
We integrated records from approximately @number@ M patients from the Medicare database with disease-gene maps that we derived from several resources including a semantic-derived knowledge-base.
We intended to analyze the effects of non-pharmacological interventions in the cognitive functions in older people with MC , in form of a systemic review.
We interpret it as indexing fluency arising from within-modality priming of visually learned names at test.
We interpret the age-related decline in grating induction magnitude at @number@ Hz to reflect a diminished capacity for inhibitory processing at higher temporal frequencies.
We interpret the results as pointing at a transition with age from synergic control to element-based control ( back-to-elements hypothesis ) .
We interpret these findings as generally supportive of a processing speed account of age-related object picture-naming difficulty.
We interpret these findings in terms of the development of functional interactions between different cortical areas involved in the processing of visual stimuli.
We interpret these findings in the sociohistorical context of this birth cohort.
We interviewed a total of @number@ elderly residents.
We interviewed nine retirees about their lived experiences with well-being and analysed the data with Giorgi's descriptive phenomenological method.
We interviewed @number@ Rochester , NY adults , ranging in age from @number@ to @number@ years.
We introduce an abdominal fat quantification method in CT with interest in food residue removal.
We introduced a novel measure of patient-centered surgical risk assessment : morphometric age.
We introduce genetic risk scores as a method of addressing these challenges and provide guidance on how genetic risk scores can be constructed.
We introduce statistical methods for predicting the types of human activity at sub-second resolution using triaxial accelerometry data.
We introduce the necessary key steps to build these applications and discuss their merits and future extensions for aging research.
We introduce this method largely in comparison to focus groups , because both represent forms of interactive interviewing.
We introduce threshold-dependent winner's-curse adjustments for marginal association coefficients that are used to weight the single-nucleotide polymorphisms ( SNPs ) in PRS.
We investigate associations between older age brain white matter structure , several measures of information processing speed and childhood cognitive ability in @number@ subjects.
We investigated a CAG trinucleotide repeat expansion in the ATXN2 gene in amyotrophic lateral sclerosis ( ALS ) .
We investigated adult age-differences in timing control of fast vs. slow repetitive movements using a dual-task approach.
We investigated age-associated differences in the motor plan by quantifying the individual activity and coordination of the agonist and antagonist muscles.
We investigated age-related change in the contribution of stroke volume ( SV ) to central PP ( cPP ) .
We investigated age-related changes in the spinal alignment in asymptomatic Japanese individuals.
We investigated age-related difference of magnitude of activation , hemodynamic time course , and functional connectivity of BOLD responses in the amygdala.
We investigated age-related EBV ( + ) B-cell lymphoproliferations in the Western population.
We investigated agreement between the two devices using Pearson correlations and Bland-Altman analysis.
We investigated alterations in gene expression induced by human beta-amyloid peptide ( Aβ ) in a Caenorhabditis elegans AD model.
We investigated alterations in plasma metabolites associated with borderline-to-moderate HTG ( triglycerides ( TG ) 150-500 mg / dL ) .
We investigated among different functions , including slope variation , which would be the best to show the relation between lens thickness and age.
We investigated associations between air pollution exposure and gene-specific methylation in @number@ elderly men participating in the Normative Aging Study ( 1999-2009 ) .
We investigated associations between miRNA related SNPs and breast cancer risk.
We investigated associations between serum nitric-oxide metabolite ( NOx ) concentrations and menopausal status.
We investigated associations between the hair As levels and BMD measurements.
We investigated associations of childhood SEP and total psychosocial adversity , with composite measures of cognitive and physical capability at mean age @number@ years.
We investigated behavioral and neural markers of emotion regulation in community-dwelling older adults , contrasting s allele carriers and long allele homozygotes.
We investigated both issues in a large population-based sample of elderly individuals.
We investigated BP-associated molecular mechanisms by integrating BP GWAS with whole blood mRNA expression profiles in @number@ individuals , using network approaches.
We investigated carotid artery geometric changes with aging to identify geometric features associated with the presence of ACD.
We investigated changes in the mean and covariance structure of face cognition abilities across the adult life span.
We investigated compounds triggering vesiculation and compounds inhibiting vesiculation induced by ionomycin.
We investigated COX-2 regulation in normal premenopausal breast tissue and its relationship to malignancy in young women.
We investigated DLB patients with preserved hippocampal volumes to determine the MRS changes in DLB with low probability of overlapping AD pathology.
We investigated DNA methylation signatures postmortem in brains of suicides with diagnosis of major depressive disorder.
We investigated effect modification by VDR genetic polymorphisms in the association between cumulative lead exposure and pulse pressure , a marker of arterial stiffness.
We investigated FRAX-estimated fracture risk in patients with type @number@ diabetes mellitus ( DM ) , compared with concomitantly enrolled control subjects.
We investigated gender differences in HRQOL and tested whether perceived discrimination accounted for these differences.
We investigated hematopoietic cell-targeted deletion of the STAT3 gene in HSCs / HPCs with a focus on mitochondrial function.
We investigated how the ability to represent \ "individual \ " faces and houses develops at the neural level.
We investigated how work-related biomechanical exposure and job strain in midlife separately and jointly predicted back and degenerative musculoskeletal diseases ( MSDs ) .
We investigated how young and older adults differ in sensorimotor tasks.
We investigated how α-synuclein accumulation affects synaptic plasticity in the mouse somatosensory cortex using two distinct approaches.
We investigated if a history of clinician-diagnosed sleep apnea or primary snoring was associated with LTL in later adulthood.
We investigated if hearing impairment is independently associated with objectively measured declines in physical functioning in a community-based sample of older adults.
We investigated if hypertension is associated with increased activities of these plasma markers.
We investigated , in an older population , low-grade inflammation and endothelial dysfunction in relation to detailed assessment of cognitive functioning.
We investigated inherited genetic variation associated with RDW in @number@ UK Biobank human volunteers.
We investigated injuries , circumstances , and the timing of fall-related hospital admissions @number@ days after fasttrack THA and TKA.
We investigated invariant perception to sizes of images.
We investigated knowledge and attitudes about older adult sexuality and dementia among staff in nursing homes ( NHs ) .
We investigated longitudinal changes in clinical biomarkers following @number@ ) HIV infection and @number@ ) ART initiation with evidence of viral suppression.
We investigated medical history and geriatric depression scale-15 ( GDS-15 ) items to determine depression and depressive symptoms.
We investigated microRNA ( miRNA ) expression and its contribution to the pathogenesis of brain AVMs.
We investigated morphometric brain changes in patients with Parkinson's disease ( PD ) that are associated with balance training.
We investigated @number@ female volunteers aged mean±SD @number@.7±5.0 years ( range 70-92 ) at high risk of fracture.
We investigated @number@ healthy subjects with no history of vertigo or balance disorder and a mean age of @number@ years.
We investigated @number@ predictors at baseline from six domains : socio-demographic , medical history , medication , psychological , sensory , and balance / gait.
We investigated pregnancy-associated plasma protein-A ( PAPP-A ) in diabetic nephropathy.
We investigated recent trends in the incidence and mortality associated with the @number@ major types of AMI.
We investigated relationships between brain structure and measures related to intracranial pulsatility among healthy elderly.
We investigated relationships between outdoor air pollution and pterygium in Korean adults.
We investigated serum levels of VEGF in AD patients with depression , AD patients without depression , and the controls , respectively.
We investigated several hallmarks of aging in hLFs from IPF patients and age-matched controls.
We investigated sex differences in the effect of aging and other risk factors for DED.
We investigated sleep and respiratory variables in healthy adults over the lifespan , and established polysomnographic normative values according to current standards.
We investigated telomere shortening over time and its relationship to clinical and lung function parameters in a COPD cohort and smoker controls without COPD.
We investigated that ROS generation of replicative senescent fibroblasts is generated by the modulation of phosphatidylinositol @number@ , 5-triphosphate ( PIP3 ) metabolism.
We investigated that the impact of living alone on institutionalization and mortality in a population-based cohort of elderly people.
We investigated the abundance and cell cycle expression of histones and histone chaperones and found defects in histone biosynthesis during replicative aging.
We investigated the accuracy of a whole-brain arterial spin-labeling technique for assessing the mean parenchymal CBF and the effect of aging in healthy volunteers.
We investigated the age dynamics of proteomic profile of urine in @number@ healthy men aged @number@ to @number@ years.
We investigated the age-stratified CAVI in healthy , normotensive individuals to evaluate the effects of age on arterial stiffness.
We investigated the aging process of these networks in human skin cells in vivo by multiphoton microscopy.
We investigated the antibacterial activity of QCZ NPs against drug-resistant Escherichia coli ( E. coli ) and Bacillus subtilis ( B. subtilis ) in vitro.
We investigated the association between age and resting state functional connectivity of several sensorimotor networks in @number@ healthy older , right-handed individuals.
We investigated the association between baseline hemoglobin concentrations and incident depression in a cohort of nondepressed elderly individuals.
We investigated the association between cardiac hemodynamics and features of brain aging in community-dwelling older subjects.
We investigated the association between circulating FGF21 levels and the cardiovascular event and mortality during a median follow-up period of @number@ months.
We investigated the association between cured meat intake and worsening asthma symptoms in adults , and the role of BMI as a potential mediator.
We investigated the association between diabetes , dyslipidemia , and HCC mortality in those aged @number@ years or more ( middle-aged and elderly ) .
We investigated the association between fruit and vegetables and symptoms of depression in the mid-age cohort of the Australian Longitudinal Study on Women's Health.
We investigated the association between plasma Hcy and epigenome-wide DNA methylation in leukocytes.
We investigated the association between vitamin D status and prevalent early AMD in a community-based cohort.
We investigated the association of APOE genotype with nonrespiratory sleep parameters.
We investigated the association of arrhythmia episodes with spatial and temporal variation in temperature.
We investigated the association of body size at birth and childhood growth with hip fractures and pharmacotherapy for osteoporosis in older age.
We investigated the association of early and late life events with HPA axis regulation in older persons.
We investigated the association of lifestyle and hormonal factors with a prospectively assessed muscle loss in older men.
We investigated the association of MDD and history of depression with hippocampal and entorhinal cortex volumes and whether HPA axis activity explained this association.
We investigated the association of MRI-derived quantitative measures of white-matter damage , global brain , and hippocampal volume with the incidence and severity of delirium.
We investigated the association of polypharmacy and sarcopenia in a large cohort of community-dwelling older adults ( 60-84 years ) .
We investigated the association of these parameters with both chronological and biological aging.
We investigated the associations between the SCL-90R and Zung Scale scores , and anthropometric , lifestyle parameters , as well as serum levels of androgens.
We investigated the associations of choline and folate intake with hepatic inflammatory injury in Taiwanese adults.
We investigated the autonomic nervous function in patients with SMID with skin vasomotor responses to cold stimuli.
We investigated the clinical correlates of elevated CSF NfL levels in FTD.
We investigated the clinical profiles and the early and long-term outcome of hospitalized patients with chest trauma , focusing particularly on elderly patients.
We investigated the composition of gut microbiota in patients with HF to elucidate whether gut microbial dysbiosis is associated with HF.
We investigated the connection between wisdom-related performance , personality , and generativity to further the understanding of how they are interrelated.
We investigated the contribution of oxidative stress-associated CpGs to development of cardiometabolic disease.
We investigated the correlation between the LIR and anxiety levels evaluated by the State-Trait Anxiety Inventory ( STAI ) test.
We investigated the cross-sectional association between fasting blood glucose ( FBG ) and cognition in an older Chinese population.
We investigated the differential impacts of fat on bone mineral density ( BMD ) according to gender and menopausal status.
We investigated the disease progression of BAFME.
We investigated the effect of aging on single or combined imaging measurements of the brainstem.
We investigated the effect of PlGF on an in vivo model of depilation-induced hair regeneration.
We investigated the effect of these two SNPs as well as the @number@ kilobases spanning region on atherosclerosis in Japanese population.
We investigated the effect of the SHMT1 rs1979277 SNP and the SHMT1 rs1979277-MTHFR rs1801133 interaction in @number@ epidemiologic cohort studies.
We investigated the effects of ADT on serum aP2 and adiponectin in PCa patients.
We investigated the effects of age and amyloid burden on fMRI activity in the default network and hippocampus during repetitive encoding.
We investigated the effects of glycitin on dermal fibroblast proliferation and migration.
We investigated the effects of GV1001 against β-amyloid ( Aβ ) oligomer-induced neurotoxicity in rat neural stem cells ( NSCs ) .
We investigated the effects of heat shock on collagenase expression when the antioxidant defense system was downregulated by knockdown of Nrf2.
We investigated the effects of moving averages of black carbon of 1-5 years before the lung function measurement using linear mixed models.
We investigated the expression and activity of Cox-2 in naïve and memory B cells from older people.
We investigated the frequencies of mutations in MAPT and GRN and the C9orf72 abnormal expansion in @number@ Korean FTD patients.
We investigated the frequency of MS in treatment-naïve , young men with congenital hypogonadal hypogonadism ( CHH ) .
We investigated the gender-specific association between eating arrangements and risk of all-cause mortality among free-living older adults.
We investigated the genetic contribution to variation in this important , health- and well-being-related trait in middle-aged and older adults.
We investigated the genetic overlap between Alzheimer's disease ( AD ) and Parkinson's disease ( PD ) .
We investigated the glycation of gelatine type A , a denatured form of collagen , which is low-cost and abundantly available.
We investigated the HAI's association with survival in the Cardiovascular Health Study and heritability in the Long Life Family Study.
We investigated the hypothesis that meal consumption may reduce tongue strength and endurance in older adults ( OAs ) .
We investigated the impact of aging on vulnerability to AM conjunction errors , and explored potential cognitive processes underlying the formation of these errors.
We investigated the impact of lifestyle modulators of colorectal cancer ( CRC ) risk on the stability of gene promoter methylation in the colonic mucosa.
We investigated the importance of the early-life environment on both telomere tracking and adult telomere length.
We investigated the incidence , determinants , and long-term clinical relevance of MD reversal after PPCI.
We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression.
We investigated the independent association of tobacco smoke exposure at various pre- and postnatal periods and overweight at age @number@
We investigated the influence of ESR2 polymorphisms on age at onset of AD in a multiethnic cohort of women.
We investigated the influence of ingestion of krill oil on cognitive function in elderly subjects by using near-infrared spectroscopy and electroencephalography.
We investigated the inhibitory effect of GO-Y030 on NF-κB activation.
We investigated the inter-rater and intrarater reliability as well as validity against volume using data from @number@ stroke patients.
We investigated the intra-individual variation of AMH levels over time for premutation carriers compared with non-carriers.
We investigated their prevalence and the predictive value of patient mid-upper arm circumference ( MUAC ) for them.
We investigated the latest chronological change ( 1995-2014 ) in gastric acid secretion in normal Japanese patients.
We investigated the lifespan of adults who recovered from IPD during a 32-year follow-up.
We investigated the neural correlates of facial processing changes in healthy aging using fMRI and an adaptation paradigm.
We investigated the neural maturation that accompanies the previously observed age-related behavioural changes in discounting , from early adolescence into mid-adulthood.
We investigated the neurocognitive correlates of MAPT haplotypes using functional magnetic resonance imaging.
We investigated the outcomes of the patients with hypoenhancement detected by MDCT.
We investigated the overall rate of in-hospital mortality following hip fracture and how this mortality rate compares across academic and community hospitals.
We investigated the performance of the latest American Diabetes Association diabetes screening methods in our aging Chinese population.
We investigated the positivity or negativity of age stereotypes with respect to different life domains.
We investigated the possibility that the observed heme degradation results from ROS generated on the membrane surface that are relatively inaccessible to the cellular antioxidants.
We investigated the possibility that trypsins are involved in vitreous type II collagen degradation.
We investigated the possible contribution of HIV infection , comorbidities and age on HRQL and depression.
We investigated the possible differences in lymphocyte subpopulations between healthy young-middle-aged and elderly subjects , focusing attention on γδ-TCR-expressing cells.
We investigated the potential association of education and marital status with hip fracture incidence in older individuals from Europe and USA.
We investigated the potential of one such compound silymarin for its anti-aging effect.
We investigated the predisposing factors associated with recurrence within the first @number@ months after an ischemic event to explore more effective preventive strategies.
We investigated the prevalence of iodine intake inadequacy in a group of elderly women living in a region of Brazil considered to be iodine-sufficient.
We investigated the prevalence of SDB using a portable monitoring system in @number@ commercial drivers.
We investigated the processes of cartilage mineralization and ossification and compared these with the known processes in growth plates.
We investigated the prognostic value of elevated erythropoietin levels on mortality among very elderly people in the general population.
We investigated the proliferation rate and expression of p16 ( INK4a ) mRNA , surface stem cell markers , and stem cell transcription factors.
We investigated the relation between scanning patterns and recognition of facial emotions.
We investigated the relationship between AASDD and olfactory performance in community-dwelling subjects.
We investigated the relationship between ACTN3 R577X polymorphism and muscle mass in both middle-aged and elderly women.
We investigated the relationship between a dominant serum AGE , N-carboxymethyl-lysine ( CML ) , and glucose metabolism.
We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over @number@ years of age.
We investigated the relationship between BMD and mitochondrial DNA ( mtDNA ) copy number in peripheral blood of postmenopausal women.
We investigated the relationship between Chagas disease and long-term stroke mortality in a large community-based cohort of older adults.
We investigated the relationship between cognitive function and lipid plasma levels of old age after controlling for apolipoprotein E ( APOE ) genotype.
We investigated the relationship between MS and the interleukin-6 system in an older population.
We investigated the relationship between serum vitamin D and brain MR findings in adult outpatients.
We investigated the relationship between ultrafine particles and particulate matter ( PM ) and daily mortality in eight European urban areas.
We investigated the relationship of LTL with CHD and mortality among AfAm.
We investigated the relationship of race and CAC in a sample of patients with type @number@ diabetes without clinical CVD.
We investigated the relationships between AS and neuropsychological performance , as well as possible correlations between AS performance and cortical thickness.
We investigated the relationships between demographic , clinical and neuropathological variables and TDP-43 proteinopathy in a large multiethnic sample of cognitively normal elderly.
We investigated the relationships between subject age and these optical quality parameters.
We investigated the role of body mass index ( BMI ) and height from infancy to adulthood in presenting with high adulthood carotid intima-media thickness.
We investigated the role of neuronal α-Syn in myelin composition and abnormalities.
We investigated the role of prefrontal structure in observed age effects on self-initiated use of memory strategies.
We investigated the role of testosterone in adverse outcomes and quality of life in an incident cohort of male Canadian hemodialysis patients.
We investigated the role of the basement membrane ( BM ) proteins nidogen-1 and nidogen-2 for the development of experimental CNV.
We investigated the role of the shear pattern in age- and aerobic exercise-induced changes in conduit artery wall thickness via cross-sectional and interventional studies.
We investigated these associations in the Korean population.
We investigated these changes in Alzheimer's disease ( AD ) and normal aging.
We investigated the sex-specific associations of ferritin levels with all-cause and cardiovascular mortality in a population-based cohort.
We investigated the size of repetition priming effects from young-old to very old age using a newly developed Word-Stem Completion ( WSC ) task.
We investigated the SNP associations with SCA in a population-based case-control study.
We investigated the sperm of @number@ male donors aged from @number@ to @number@ years old.
We investigated the sub-nuclear localization of hEXO1 during S-phase progression and in response to laser-induced DNA double strand breaks ( DSBs ) .
We investigated the temporal relationship between lifestyle and mental health among @number@ midlife women.
We investigated the urine proteomes in healthy elderly people to determine which metabolic processes were weakened or strengthened in aging humans.
We investigated the utility of sulcal width measures in the diagnosis of Alzheimer's disease ( AD ) .
We investigated this issue in a large cohort of nurses.
We investigated this list of markers using similar genetic data from @number@ studies of centenarians from the USA , Europe and Japan.
We investigated this putative deficit by means of event-related potentials ( ERPs ) .
We investigated this question by employing linear regression models of performance in analogy tasks and voxel-based morphometry in @number@ healthy subjects.
We investigated this question via a virtual reality route memory task.
We investigated this relation in two distinct cognitively healthy populations separated by age ( @number@ young adults and @number@ older adults ) .
We investigated this variant in @number@ late-onset Alzheimer's disease cases and @number@ elderly control subjects , all North American Whites ( US Whites ) .
We investigated transfer to tasks engaging executive functions , and compared the effects in older adults to those reported in young adults.
We investigated whether AASI could predict GFR decline measured as iohexol clearance in the general population.
We investigated whether advanced age was associated with higher rate and severity of postoperative complications.
We investigated whether age differences in feeling-of-knowing ( FOK ) account for older adults ' delayed retrieval shift.
We investigated whether alcohol abuse by young people ( binge drinking ) causes alterations comparable to some found in elderly people.
We investigated whether a yellow filter can reduce age-related visual deficits.
We investigated whether central and / or peripheral arterial stiffness contributes to increased perceived fatigue during walking in mobility-intact older adults.
We investigated whether cerebral vasomotor reactivity is associated with the risk of mortality , focusing particularly on cardiovascular mortality independent from stroke.
We investigated whether CMBs-independent of other traditional markers of cerebral small vessel disease-are related to cognition.
We investigated whether CMV infection contributes to T cell ageing in ESRD patients.
We investigated whether COMT influences language ability and cortical language processing involving the posterior language regions in @number@ children aged 6-10 years.
We investigated whether dietary pattern associates with cognitive function in middle-age.
We investigated whether diets with different fat and carbohydrate contents over three generations modifies markers of ageing.
We investigated whether DJ-1 can be degraded in oxidative-stressed dopaminergic neuronal cells , leading to loss of its protective role against oxidative stress.
We investigated whether glucocorticoid ( GC ) activity , which increases in old age , is involved in this process.
We investigated whether hearing loss is associated with firefighting.
We investigated whether HIV-1-infection would induce age-associated methylation changes.
We investigated whether individual differences in general fluid intelligence and speed of processing would predict inattentional blindness in our sample of older adults.
We investigated whether inexperienced evaluators could accurately obtain and analyze ultrasound images.
We investigated whether living donor liver transplantation ( LDLT ) results in improvement in male sexual function.
We investigated whether Lynx pilots demonstrated changes to hearing thresholds that differed from Apache pilots.
We investigated whether modifications of glycosaminoglycans in human abdominal aortic aneurysm affect their anticoagulant properties.
We investigated whether nebivolol is able to induce β3AR-mediated lipolysis , uncoupling protein @number@ ( UCP1 ) , and size-reduction in human adipocytes.
We investigated whether older physicians , who are health-conscious people , are at a lower risk of hip fractures because of fewer trochanteric fractures.
We investigated whether pain predicted change in FI between Waves @number@ and @number@ using a negative binomial regression model.
We investigated whether replenishing EZH2 could reverse the age-dependent increase of Ink4a transcription.
We investigated whether sAβPPα could influence the expression of RACK-1 through NF-κB involvement.
We investigated whether SCD in patients with Parkinson's disease ( PD ) is a predictor of future cognitive decline.
We investigated whether serum FGF21 was predictive of the development of diabetic nephropathy.
We investigated whether specific proinflammatory cytokines contribute to arterial aging , independent of age , sex , MetS , and other traditional CV risk factors.
We investigated whether the expression of Klotho , assessed by immunohistochemistry , can predict survival in patients with resected SCLC.
We investigated whether the GSTP1 Val105 and GSTM1 deletion polymorphisms modify the lead-cognitive function association.
We investigated whether the immunohistochemical expression of Klotho can predict survival patients with resected LCNEC.
We investigated whether the natural variation in sleep among older adults is associated with daytime cortisol level.
We investigated whether the PBI shredder is useful in preparing a muscle homogenate for measurements of mitochondrial respiratory capacity.
We investigated whether the processing-speed hypothesis in aging also explains the unique contribution that CPS may have to EF deficits in CVD patients.
We investigated whether there are causal associations between 25-hydroxyvitamin D concentrations and features of skin aging in a bidirectional Mendelian randomization study.
We investigated whether there are sex differences in the association between pain and incident injurious falls.
We investigated whether there is a laterality effect in judging emotions from the eyes.
We investigated whether there is an imaging signature of AD pathology in these atypical subjects.
We investigated whether the relationship between suicidal ideation and established correlates varied by age in a representative population.
We investigated whether the upswing in BMI at AR is accompanied by an increase in body fat.
We investigated whether this association could be mediated or modified by traditional cardiovascular risk factors as well as inflammatory status.
We investigated whether this association was modified by genotype and phenotype.
We investigated whether this phenotypic association arises from a shared genetic basis.
We investigated whether this tool can usefully characterize chemotherapy risks for older patients with lung cancer.
We investigated whether transcranial direct current stimulation ( tDCS ) would facilitate this phenomena in older adults.
We investigated whether transplantation of human umbilical cord blood-derived MSCs ( uMSCs ) is useful in alleviating lupus nephritis in a murine model.
We investigated whether weakness of biceps brachii in aging analogously relates to processes in M1.
We investigated whether young age ( 18-30 years ) had an independent effect on survival.
We investigated which cognitive variables were best predictors , and which of these variables remained predictive for patients with longer times to conversion.
We investigated work ability in midlife among white-collar and blue-collar employees as a predictor of mortality and disability @number@ years later.
We investigate hippocampal integrity using quantitative MRI techniques and its association with cognitive abilities in older age.
We investigate how varying forms of social support moderate depressive symptomatology among older adults with multiple chronic conditions ( MCC ) .
We investigate @number@ potential mediational pathways through which social activity may relate to cognitive performance.
We investigate one of the possible mechanisms , and argue that subjective appraisals rather than received amounts of social support affect cognitive functioning.
We investigate possible moderation effects of cognitive functions relative to demographic characteristics , socioeconomic status , and household composition variables.
We investigate the association of brain volume to total and cause-specific mortality in a large nondemented stroke-free community-based cohort.
We investigate the effect of both policies on subjective well-being of the elderly.
We investigate the failure to ensure COs in juvenile male mice.
We investigate the impact of peer competition on longevity using a unique historical data set of @number@ prominent music composers born in the 19th century.
We investigate the impact of pharmaceutical innovation on longevity , hospitalization and medical expenditure in Turkey during the period 1999-2010 using longitudinal , disease-level data.
We investigate the link between telomere dysfunction and oxidative and DNA damage response pathways and assess the effects of antioxidants.
We investigate this hypothesis in a new study of language development , aging , and pathology.
We investigate this using a neuroimaging model that predicts brain age in healthy individuals and then apply it to TBI patients.
We investigate whether effects on and pathways to mortality risk differ between functional and structural characteristics of the personal network.
We investigate whether push-off force-time relations during the execution of rapid voluntary stepping is affected by a secondary task in older and young adults.
We investigate whether this also occurs in children.
We invited @number@ nursing homes in Kanagawa prefecture in Japan , a region with a rapidly aging population , to participate in the study.
We isolated a small vasohibin-binding protein ( SVBP ) composed of @number@ amino acids.
We isolated MSCs from bursa tissue associated with rotator cuff tendons and characterized them for multilineage differentiation in vitro and in vivo.
We isolated @number@ different antibody fragments that bind oligomeric but not monomeric or fibrillar tau.
We issue a call for a universal-ASD that can be applied across different cultural contexts.
We knocked down LKB1 by siRNA transfection.
We know its cellular localization , catalytic activities , substrates and the pathways it is involved in.
We know less about the intersections of relationship and gender.
We know little about the support needs and health of older lesbians because participant sexual identity has typically not been identified in aging studies.
We know much about caregiving women compared with caregiving men and caregiving spouses compared with caregiving adult children.
We know that transplanted RPE monolayers will encounter a hostile sub-RPE environment , including age-related alterations in BM that may compromise cell function and survival.
We lastly formally tested for , but found little evidence of , recall bias of the retrospective subjective reports of childhood context.
We last searched the electronic databases on @date@ .
We leveraged available neuropsychological and autopsy data from @number@ cohort studies to investigate whether these loci are associated with cognitive decline and AD neuropathology.
We leveraged the analyses of pleiotropy , age-related heterogeneity , and causal inferences.
We leveraged the idea that averaging BP measured across time would improve phenotypic accuracy and thereby increase statistical power to detect genetic associations.
We live in a multisensory world and one of the challenges the brain is faced with is deciding what information belongs together.
Well-being in retirement depends largely on financial preparedness during working life.
Wellbeing might also have a protective role in health maintenance.
Well-being of midage women with indicators of DE needs to be supported by tailoring prevention and interventions activities specifically for this group.
Well controlled , large scale studies are needed to assess the effects of phytoestrogens on the aging brain and provide further understanding of this association.
Well-defined 24-hour plasma melatonin rhythms were observed in all the males but only the old animals showed significant attenuation of night-time melatonin levels.
Well-defined changes in body composition occur in aging animals and humans.
Well-defined problems ( e.g. , completing a series of errands ) may rely primarily on executive functions.
Well-designed psychoeducation interventions or multicomponent interventions could help in reducing caregivers ' burden.
Well-developed fibrous tissue connected the inferior vaginal wall with urethra , rectum and pelvic floor.
We looked at reviews of agents to identify important studies for consideration that searches may have missed.
We looked for associations of natural aging with expression and methylation of this gene in blood mononuclear cells and with its common polymorphisms.
We looked for potential differences in the serum levels of toxic tau oligomers in regards to cognitive impairment of subjects.
We looked into our cohort of @number@ DS cases with dementia for the effect of BACE2 variants in age of onset of dementia.
We macroscopically assessed the anatomy of the postero-inferior area of the lateral left atrial wall.
We made a conclusion that people with older age and lower FEV1%pred tend to have a smaller FVC than VC in pre-bronchdilator spirometry.
We made significant changes to the instructions after the pilot studies to increase comprehensibility and reduce the completion time.
We made the novel finding that low or high dose resveratrol had an initially different mechanism on induction of differentiation.
We make all these data available.
We make a number of suggestions for research and practice.
We make general recommendations about improved methodological approaches toward identification and regulation of chemicals that are gerontogenic to the brain.
We manipulated available visual information by presenting the target blocks in isolation in Experiment @number@ and in streams of blocks in Experiment @number@
We manipulated physical and dexterity demands by changing , respectively , external resistance and target size.
We manipulated the predictability of a sentence-final target word , operationalized as cloze probability.
We manipulate list strength in order to investigate two aspects of response bias.
We map geographical concentrations by decade and contrast trends in age-adjusted incidence rates , comparing the results to an index of socioeconomic deprivation.
We mapped architectural changes in genome organization in cellular senescence using Hi-C.
We mapped palmitoylation to Cys212 and Cys284 , which are critical for both association of gephyrin with the postsynaptic membrane and gephyrin clustering.
We mapped the interaction between E2F1 and FOXO3 to a region including the DNA binding domain of E2F1 and the C-terminal transcription-activation domain of FOXO3.
We mapped the interaction site to the N-terminal @number@ amino acids of Exo70 , which interfere with pre-mRNA splicing in vitro.
We matched five noncarrier controls to each NMC and followed them for an average of @number@ years with annual cognitive and motor examinations.
We may benefit from intervention studies examining the effect of routine preconception care.
We may hence recommend cc2 time as convenient parameter at embryo selection for embryo transfer in the centres of assisted reproduction.
We may infer that both HA preparations work synergically , enhancing their positive activities.
We may need to make an effort to reduce high-dose mediastinal RT to the myocardium in RT planning.
We measured absolute telomere length ( aTL ) in peripheral leukocytes from @number@ HIV-infected adults.
We measured a decreased level of GSK-3β in the cortex of the mice , indicating the success of the antisense treatment.
We measured alterations in cortical thickness ( CT ) caused by early visual deprivation and their relationship with cortical activity.
We measured aortic pulse wave velocity by applanation tonometry among @number@ men and women aged @number@ to @number@ years.
We measured blood pressure ( BP ) both in the clinic and using 24-hour ambulatory BP monitors for all subjects.
We measured BMD using dual-energy x-ray absorptiometry and leukocyte mtDNA copy number using real-time polymerase chain reaction.
We measured bone mineral density ( BMD ) and appendicular muscle mass using the dual-energy X-ray absorptiometry and also measured metabolic profiles.
We measured cartilage concentrations ( normalized to dry weight ) of racemized aspartate , GAG , COMP and deamidated COMP ( D-COMP ) .
We measured CAVI and examined blood samples to define metabolic syndrome according to the International Diabetes Federation criteria.
We measured CKD prevalence and eGFR , and their relationship with traditional and additional risk factors , in a Sardinian founder population cohort.
We measured clinic and clinician recruitment rates , questionnaire completion rates , patient eligibility rates , and estimated the RCT needed sample size.
We measured concentrations of bile acid , cholesterol , and phospholipid in bile and rates of bile flow.
We measured Cp concentrations and activity in plasma samples collected from adults and fetuses of humans and sheep.
We measured disability with the Katz Activities of Daily Living.
We measured dissemination and teaching efforts by our trainers and evidence of EPEC use via literature and EPEC's searches.
We measured DNA methylation of estrogen receptor alpha ( ERα ) and secreted frizzled related protein-1 ( SFRP1 ) , using bisulfite pyrosequencing.
We measured each person's social network , i.e. , degree , efficiency , and variety.
We measured follicle-stimulating hormone and luteinizing hormone and added information on menstrual patterns to determine menopausal status using latent class analysis.
We measured fractional anisotropy ( FA ) , apparent diffusion coefficient ( ADC ) , and tract number for each part of the fornix.
We measured gait speed on an automated walkway and information-processing ability on the Digit Symbol Substitution test ( DSST ) .
We measured HDL particle size , HDL particle number , and LDL particle number with NMR spectroscopy , as well as HDL efflux capacity.
We measured isokinetic knee extensor and plantarflexor power and measured hip , knee and ankle kinetics at habitual , fast and standardized walking speeds.
We measured klotho in the CSF of @number@ older adults with Alzheimer's disease and in @number@ older and @number@ younger adults with normal cognition.
We measured levels of mRNAs by quantitative reverse transcription polymerase chain reaction in liver biopsies from patients with varying degrees of hepatic steatosis.
We measured LTL by Southern blots and IGF-1 by enzyme-linked immunoassay.
We measured maternal PlGF and sFlt-1 in the first and second trimester of pregnancy.
We measured maximal isometric voluntary force of three muscle groups in the right leg.
We measured mean diffusivity ( MD ) and fractional anisotropy ( FA ) , as assessed by DTI in both WML and NAWM.
We measured motor evoked potentials ( MEPs ) before QPS , and at five time points after QPS for up to @number@ min.
We measured muscle mass , grip strength and gait speed and assessed how changes in cut-off points changed sarcopenia prevalence in both populations.
We measured muscle strength , mid-thigh cross-sectional area , fasting morning plasma cortisol , quadriceps muscle GR and 11βHSD1 mRNA , and urinary glucocorticoid metabolites.
We measured normalized-rCMRglc in @number@ regions of interest.
We measured @number@ SORL1 SNP alleles.
We measured plasma GDF-11 and β2-MG levels using ELISA and immunoturbidimetry , respectively.
We measured retinal vascular fractal dimension ( Df ) as a potential marker of cerebral microvascular disease.
We measured serum and mRNA expression levels of inflammatory markers in PBMCs.
We measured serum levels of fasting glucose and insulin , and derived the homeostatic model assessment ( HOMA ) index to assess IR.
We measured serum periostin with a new ELISA optimised for human serum and plasma which recognises all known splice variants ( Biomedica ) .
We measured SES using self-reported levels of education , household income and occupational prestige.
We measured several characteristics of COPD in young and old mice ( @number@ and @number@ months of age ) exposed to CS for @number@ months.
We measured spontaneous oscillation of oxyhemoglobin ( oxy-Hb ) concentrations in the bilateral PFC at rest in normal adults employing two-channel NIRS.
We measured strength as force of elbow flexion and electromyographic activation of biceps brachii during maximum voluntary contraction.
We measured telomere length ( T / S ratio ) at baseline using quantitative PCR.
We measured the apophyseal cartilage thickness at the enthesis.
We measured the association of highest attained education level with preclinical mobility disability ( PCD ) over an 11-year period.
We measured the cellular levels of procollagen type I and MMP-1 using ELISA in NHDF cells after UVB irradiation.
We measured the compensation for speech degradation using phonemic restoration , where intelligibility of degraded speech is enhanced using top-down repair mechanisms.
We measured the consequence of having successfully resolved competition by having participants read a list of words including the rejected competitors as quickly as possible.
We measured the degree of behavioral compensation ( peak compensation ) and the extent of the adaptive response ( pitch-response persistence ) .
We measured the fractional area covered by vimentin immunoreactivity in the INF.
We measured the glomerular endothelial cell area in C4d ( + ) and C4d ( - ) acute rejections by morphometry.
We measured their metabolic rate continuously via expired gas analysis.
We measured the LFA and LFT at the L4-L5 intervertebral level on MRI using a picture archiving and communications system.
We measured the limits of the ability to recognize faces across the lifespan by young versus old men and women.
We measured the microstructural parameters of lumbar bone from women in several age groups by micro-computed tomography and scanning electron microscopy.
We measured the movement velocity of the upper limbs , maximum gait speed , quadriceps strength , trunk muscle endurance and skeletal muscle mass index.
We measured the outcome as scores on the Patients Expectations Scale , Communication Scale , Attitude Toward Treatment and Health Scale , and Self-Efficacy Scale.
We measured the pattern of growth in individuals with long-term radiologic follow-up.
We measured the T1ρ and T2 values ( ms ) in the regions of interest set on the full-thickness patella cartilage.
We measured three markers in peripheral blood to evaluate the antiaging effects of a food supplement containing placental extract.
We measured traditional CVD risk factors including age , biophysical profile , fasting blood sugar and serum lipid profile as well as biomarkers of inflammation.
We measured venous samples from Days @number@ @number@ and @number@ for HI and VNA and B-cell ELISPOTs.
We measured whole-brain longitudinal and transverse relaxation rates as well as the myelin water fraction from each of these individuals.
We measured WMH volumetrically and visually using the Fazekas scale.
We measure experienced well-being as ratings of happiness and frustration during activities recalled for the previous day.
We meta-analysed heart rate association results from @number@ @number@ European-ancestry individuals from @number@ cohorts , genotyped using the Exome Chip.
We might similarly ask \ "Can the old speak ? \ "
We modeled a pentavalent vaccine covering serotypes 1a , 1b , II , III , and V , which cause almost all GBS disease.
We modeled associations using unweighted and weighted scores with estimates derived from the literature.
We modeled empathy by measuring the freezing of observer mice to observing the footshock of a subject mouse.
We modeled the implications for sample size , screen fail rates , and trial cost and duration.
We modeled the relations between whole-GM SDBOLD with cognitive performance using multivariate partial least squares analysis.
We modeled the relationships between CRF , PA , and brain functional integrity using multivariate partial least squares analysis.
We modeled the thigh 3D geometry and compared DXA and computed tomography ( CT ) measures.
We modified computer laboratory ergonomics to accommodate mobility needs.
We modified the previously reported method by using a shorter amplicon and confirmed the efficiency and utility of this method in this report.
We monitored survival during the follow-up period and , at study exit , assessed the mood , cognition and functional status of survivors.
We monitored the impact of diflunisal on the prestin-dependent non-linear capacitance and electromotility.
We morphed faces to change linearly from one identity to another.
We must be considered for new approaches to these intractable secondary pneumothoraces which replaced traditional conservative and surgical approaches.
We mutate many genes encompassing the hallmarks of aging , and for a subset , we produce stable lines within 2-3 months.
We name this phenomenon of nuclear occurrence of mitochondrial component as numtogenesis.
We need an understanding of the clinical processes , the time course , the natural history , and disruptors of these processes.
We need innovative solutions that can offer reasonable service while recognizing the value of acceptable risk taking.
We need more specific studies about bipolar disorder treatment in aging.
We need to acknowledge , as has been done in other specialties , that people differ in their response to drugs.
We need to educate the public to recognize the symptoms of sleep apnea and to publicize that effective treatments are available.
We need to move faster.
We need to plan a comprehensive strategy addressing issues related to availability , affordability , accessibility and acceptability of eye-care services.
We need to plan a comprehensive strategy to deliver the services in developing countries if we want to achieve our goal of VISION @number@
We neither found significant differences between patients with PD and AP nor between AP subgroups.
We newly synthesized six 2-methyl-2- ( o-tolyloxy ) propanoic acid derivatives based on the structure of a well-known PPAR pan agonist , bezafibrate.
We next analyzed FXR-Gank-Tumor suppressor pathways in a large cohort of HBL patients which include @number@ controls and @number@ HBL samples.
We next established significant heritabilities in both sexes for all traits.
We next evaluated cellular responses of primary gingival fibroblast obtained from young subjects in the presence human blood serum of individuals of different ages.
We next explore rodent models of orexin in aging , presenting evidence that orexin loss contributes to age-related changes in sleep and energy balance.
We next focused on @number@ predicted miR-29 target genes ( Igf1 , Imp1 , and Mest ) , all of which are growth-promoting.
We next generated a transgenic mouse that expressed a dominant-negative inhibitor of RbAp48 in the adult forebrain.
We next investigated patterns of disorder comorbidity for past-year psychiatric disorders and found that a liability model fit the data well.
We next showed that scale invariance can be restored by returning the running wheels.
We next tested whether activation of rapamycin-insensitive pathways would shift quiescence towards senescence.
We noninvasively stimulated the motor cortex to produce a change in unimanual strength and noise , and found a corresponding change in bimanual control.
We noted increased mortality by increasing ERA score , in patients undergoing CABG or PCI.
We noted the variance contributed by these SNPs is higher than that of the control.
We note that there are several studies showing conflicting results.
We note that we do not focus on the identification of ' active subnetworks'.
We noticed that a synthetic inhibitor of CDK @date@ ( PD0332991 ) also induced cyclin D1-positive senescence.
We noticed that complications typically appear several years after injection.
We noticed that SAMP10 / TaSlc mice , a SAMP10 substrain , have developed persistent glucosuria over the past few years.
We now ask whether human skeletal muscle accumulates aggregates with age.
We now assessed whether blood [ HA ] were elevated in Parkinson's disease ( PD ) as well.
We now know that the requirements set for vitamin D intake were too low and not properly age adjusted.
We now provide evidence that BDNF regulates heart rate by a mechanism involving increased brainstem cardioinhibitory parasympathetic activity.
We now report a function of Rhes in autophagy , a lysosomal degradation pathway implicated in aging and HD neurodegeneration.
We now review the experimental model and its contribution to identifying novel therapeutic targets in kidney injury and fibrosis , independently of the noxa.
We now show that hESCs also use nonhomologous end joining ( NHEJ ) .
We now show that silencing of the tumor suppressor TP53 decreases truncation and increases drug-induced apoptosis.
We now show that the expression of molecules involved in the maintenance of immunological memory in the human BM changes with age.
We now understand that these factors can actually be causative biological mediators of cell growth to control organ size.
We objectively quantified and qualified the benefits of applying cosmetic make-up.
We observe a fragmentation similar to the age-dependent study in almost all parameters.
We observe an RNA-dependent interaction between ADAR1 and ADAR2.
We observed a bias as nearly all of the studies were from India.
We observed a dose-dependent effect of objectively monitored physical activity on physical functioning and onset of major mobility disability.
We observed a faster healing time and less recurrence of complications in patients who underwent topic treatment with alpha-tocopherol acetate.
We observed a like impact on the metabolome and identified distinct metabolites affected by CR and RM.
We observed a linear increase in CHD-related hospital in-patient care costs across PI groups.
We observed a moderate association of common variants , confirming the involvement of the known PD risk loci within our genetic data sets.
We observed an association between the levels of inflammatory markers and peripheral lean body mass , physical performance , and BMI.
We observed and compared them to the previous HDSS survey rounds and found no significant differences for household size and gender compositions in CHILILAB HDSS.
We observed an increase in intima-media thickness of @number@ mm in diabetics and of @number@ mm in controls with every additional year of age.
We observed an increase in tubulin post-translational modifications related to microtubule stability.
We observed an increment in lipid peroxidation levels and GPx levels with risedronate.
We observed an interaction between sleep duration , diabetes mellitus and log-WMHV ( P = @number@ ) .
We observed a predominance of cross-sectional studies , use of different clinical indices of progression , and high heterogeneity in age-control procedures.
We observed a prevalence of cancers related to ESKD ( @number@ @percent@ ) .
We observed a sharp decrease in Akt activity during this process , suggesting a possible role of the PI3K-Akt pathway in hSKP maintenance in vitro.
We observed a significant decrease in eHsp70 concentration in the HIGH group for female , but not male , subjects.
We observed a significant decrease in the levels of HNE-lipoic acid in the AD brain compared to that of age-matched controls.
We observed a significant interaction between smoking and AHEI-2010 on change in asthma symptoms ( P for interaction = 0·04 ) .
We observed a significantly lower number of activated and proliferating γδ T cells at baseline and following vaccination in elderly as compared to young individuals.
We observed a similar actin fragmentation and release in RBC lysates from beta-thalassaemic patients.
We observed a similar spectrum of risk associated with these markers in Japanese.
We observed association between the A allele and genotype homozygous for this allele ( AA ) with a longer life expectancy in the male population.
We observed a stable or increased association between waist circumference and insulin resistance ( Homeostasis Model of Assessment-Insulin Resistance index ) and fasting plasma glucose.
We observed a strong association between the presence of TB and risk of nodal metastasis in pT1 CRC.
We observed a strong gender-specific difference in this association , with men benefitting more from exercise.
We observed a switch from frontal to temporo-parietal regions as words retrieval become more difficult over time.
We observed a trend towards hypomethylation in the gene body region of the XIST locus in PD females which did not reach significance.
We observed changes in lumbar cancellous bone mineral density and in biomechanical parameters with aging to elucidate the relationship between age and risk of fracture.
We observed characteristic senescence markers but the number of DNA damage foci decreased.
We observed considerable overlap in regions with the strongest loss of cerebellar volume in the two datasets.
We observed constitutively high levels of Nox4 gene / protein and activity in a model of replication-induced cellular senescence of lung fibroblasts.
We observed differences in support and related services by both unit count and province.
We observed ; different aspects of gait reflected different functional outcomes.
We observed docking of IGFBP-3 containing structures to the nuclear envelope and found IGFBP-3 containing dot-like structures to permeate the nuclear envelope.
We observed genome-wide downregulation of hsa-miR-132-3p and hsa-miR-212-3p in AD with a stronger decrease in gray matter AD samples.
We observed high levels of PTH ( > @number@ pg / mL ) in @number@ patients ( @percent@ ) .
We observed improved glucose tolerance and restoration of GLUT2 expression in VHL-deficient β-cells in response to rHuEPO.
We observed increased autophagy in WRN knockdown cells ; this was further increased by short-term rapamycin treatment.
We observed increased water secretion from hepatocytes into bile canaliculi to mediate these effects , resulting in suppression of cholelithogenesis.
We observed independent increases in potential DDIs per person in association with aging and increasing number of prescribed drugs.
We observed longitudinal fMRI activation increases in bilateral regions of lateral frontal cortex at time point @number@
We observed lower expression and fragmentation of beta-actin after exposure to hypoxia.
We observed marked age-related changes in homotopic RSFC with regionally specific developmental trajectories of varying levels of complexity.
We observed more accurate source judgments for repeated versus non-repeated visually learned names , but no such effect for repeated versus non-repeated auditorily learned names.
We observed no association between neighborhood built environment or change in built environment and BMI.
We observed no association between trabecular vBMD and AVC or MVC in women or men.
We observed no association of the other two SNPs in miR-196a2 ( rs11614913 ) and miR-499 ( rs3746444 ) with the CAD incidence.
We observed no associations between fertility and age at menarche ( p = @number@ ) and menopause ( p = @number@ ) .
We observed no association with albuminuria.
We observed no difference in ePiB between PiB-positive and -negative subjects and carriers and noncarriers.
We observed no effect of any of the genetic factors investigated on cognitive performance.
We observed no protective associations with early timing of hormone initiation.
We observed no significant association for 1-year changes in these ratios or any effect modification by the Mediterranean diet ( MD ) intervention.
We observed no significant changes in MTL according to the average active bone marrow dose.
We observed no significant interactions.
We observed notable APOBEC mutagenesis patterns and identified SHKBP1 , ERBB3 , CASP8 , HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer.
We observed @number@ cases of incident stroke ( @number@ ischemic ) and @number@ cases of incident dementia ( @number@ consistent with Alzheimer's disease ) .
We observed @number@ HF events ( @number@ HFpEF and @number@ HFrEF events ) over @number@ years of follow-up.
We observed @number@ incident cases of T2D during a mean follow-up period of @number@ y ( range @date@ @number@ y ) .
We observed one ICH ( @number@.3% / y ) and @number@ recurrent AIS ( @number@.7% / y ) .
We observed pathogenic repeat expansions in a family with ALS-FTD and in a patient with sporadic FTD.
We observed progressive downregulation of CB and CaMKI RNA in laser-captured BFCN in the normal-aged-AD continuum.
We observed reductions of intrinsic activity in MCI patients.
We observed shared alleles among @number@ patients for @number@ consecutive short tandem repeat markers spanning a @number@ Mb region.
We observed significant adjusted associations of TST with impaired 3MS performance and of WASO with impaired delayed recall , semantic fluency , and digit span.
We observed significant association with rare missense alleles in genes other than CFI.
We observed significant effects of APOE ε4 on Aβ ( @number@ ) levels in both diagnostic groups by disease stage and region.
We observed significant enrichment in DNase I hypersensitive sites in fetal heart and lung.
We observed significant replication for both CpG sites ( P < 5.0E-8 ) in a second set of peripheral blood samples.
We observed similar associations of DAo plaque burden with TCBV and WMHV.
We observed similar results for cardiovascular mortality , but there was no significant linear association between 25 ( OH ) D and cancer mortality.
We observed some correlation between some senescence markers and physical performance but no improvement in frailty with rapamycin was noted.
We observed substantial conservation of RNA-editing levels between the brain regions , as well as among the three primate species.
We observed that a panel of @number@ 2DGE plasma protein spots effectively discriminated between individuals with high and low brain Aβ.
We observed that a younger biological age associates with lower levels of p16INK4a positive cells in human skin.
We observed that CHIP deficiency leads to increased levels of the insulin receptor ( INSR ) and reduced lifespan of worms and flies.
We observed that co-expression of synphilin-1 mildly delayed the motor phenotype caused by A30P alpha-synuclein.
We observed that downregulation of PINK1 enhanced alpha-synuclein aggregation and apoptosis in a neuronal cell culture model for synucleinopathy.
We observed that E14 and E17 neurons in culture were prone to death after the Aβ and particularly the kainic acid treatment.
We observed that fat fraction ( FF ) can discriminate healthy and osteoporotic patients.
We observed that first trimester maternal PlGF and sFlt-1 levels were not associated with childhood retinal arteriolar caliber.
We observed that GxE GWAS for the environmental factor contributing a significant GxE variance yielded more significant SNPs than the control factor.
We observed that HSCs express high levels of Pot1a during development , and this expression declines with aging.
We observed that individuals over ~90 years old carried low levels of heteroplasmic variants in their genomes.
We observed that , in parallel to reduced levels of tPA in OLs , white matter gets more susceptible to ischemia in old mice.
We observed that monocytes and naïve CD8 T cells expressed higher levels of CCL4 and exhibited an age-related increase in CCL4.
We observed that older men produced greater rightward line bisection errors , of primarily \ "where \ " spatial character.
We observed that osteons did become less elliptical in cross-section with age independent of orientation - suggesting this is a real change in morphology.
We observed that @percent@ of modern mitogenomes cluster into @number@ haplogroups that most likely arose in situ.
We observed that phlorizin pretreatments inhibited HaCaT cell apoptosis and overproduction of ROS induced by UVB.
We observed that resting repertoires of B cells overexpressed V genes that were especially biased toward focused mutation and change in the CDR.
We observed that ROS and NO increase with aging , while SOD activity is significantly reduced.
We observed that the exposed ( @number@ ) NGR site can deamidate under conditions mimicking accelerated Asn aging.
We observed that the health-related quality of life and auditory performance increased significantly after cochlear implantation for the study cohort.
We observed that the human brain functional connectome exhibited highly preserved non-random modular and rich club organization over the entire age range studied.
We observed that the methylation age at birth was independent of the infant's sex but was significantly influenced by race.
We observed that values of parameters VMS , P1 , and P2 increase in accordance with the age , but H level decreases.
We observed the agonist-specific activation pattern of MAP kinases in human diploid fibroblasts ( HDFs ) .
We observed two age-related effects.
We observed typical non-linear developmental decreases in delta and theta power for both ADHD and control groups.
We observe that the expression of several selenoproteins involved in antioxidant defense is specifically affected in response to cellular senescence.
We obtained and characterized PRGF-Endoret preparations from human blood.
We obtained area under the curves of @percent@ for SI and @percent@ for future hospitalizations in independent cohorts.
We obtained a SUS score of @number@ ( @number@ is considered to be the cut-off point for usable systems ) .
We obtained data from the National Institute on Aging CALERIE randomized trial through its public-access biobank ( @url@
We obtained data on age at diagnosis , primary location , race , stage , sex , radiological treatment status , and surgical treatment status.
We obtained data on grandmaternal ages in @number@ families of DS and @number@ families of healthy children born in 1990-1999.
We obtained data related to consecutive time series with R-R interval ( RRI ) and pulse transit time ( PTT ) .
We obtained DNA methylation profiles in whole blood samples by Illumina HumanMethylation450 BeadChip and calculated the FI according to the method of Mitnitski and Rockwood.
We obtained extensive clinical and survey data on @number@ enrolled patients , with average age @number@ ± @number@ years , @percent@ men.
We obtained four factors with good internal consistency ( Cronbach's alpha > @number@ ) .
We obtained hMSCs from the femoral heads of women undergoing hip replacement due to hip fractures and controls with hip osteoarthritis.
We obtained initial evidence that some of these associations were stronger among the oldest-old participants.
We obtained similar results when we limited analyses to participants younger than @number@ years at baseline.
We obtained the effect estimates through a random-effects meta-analysis.
We obtained the genotype data for @number@ candidate SNPs and for a further @number@ SNPs from @number@ related candidate genes.
We obtained two three-dimensional facial shape measurements in @number@ Japanese males at intervals of approximately @number@ years.
We obtain evidence from the literature regarding the role of pre-physical frailty in pathological aging.
We offer a theoretical model of the development of severe health anxiety among older adults to encourage further research on this important and under-studied topic.
We offer further insight into how D-scoring controls for method effects in IATs and what IAT scores capture in addition to implicit representations of characteristics.
We offer insight on how we might define and characterize disasters , and illustrate that long-term catastrophes \ "age \ " in specific ways.
We only included studies that were conducted in primary care populations.
We operationalized \ "exceptional aging \ " without ADP by considering individuals @number@ years or older to be without significant evidence of ADP.
We outline an interdisciplinary approach to designing and evaluating portal-based messages that convey clinical test results so as to support patient-centered care.
We outline a number of future directions that will broaden our current understanding of these brain-behavior relationships in aging.
We outline how early practice contributes to optimizing strategic planning to avoid worst-case outcomes associated with inherent neural-motor variability.
We outline how structurally diverse phytochemicals modulate a complex network of signaling pathways that orchestrate a distinct set of longevity-defining cellular processes.
We outline recent advances in medical practice that have positively affected both the quality of care and its cost-effectiveness.
We outline the impact of vaccines on the burden of common infectious diseases and consider the negative clinical impact of VPDs in the unvaccinated population.
We outline the most important unanswered questions and directions for future research in this vibrant and rapidly evolving field.
We overcome the influence of PVEs by separating isotropic signal from diffusion-weighted signal , which can provide more accurate estimation of fiber orientations.
We overexpressed ACSL3 in androgen-dependent LNCaP cells and examined the downstream effectors of ACSL3.
We particularly emphasized large multi-center epidemiologic studies of the natural history of patients with carotid IMT measurements.
We particularly focus on the proteolytic aspect of MQC and its impact on health and aging.
We particularly focus on the roles of chromatin-modifying complexes and transcription factors that directly impact chromatin in aging stem cells.
We pay attention to translation of pathophysiological insights gained from in vitro experiments and animal models to patients.
We pay close attention to the type and number of family structure transitions experienced and examine whether associations differ depending on family structure at birth.
We pay particular attention to the relationship between coresidence and indicators of parental and child needs.
We perform a descriptive retrospective analysis.
We perform a structural homology search and reveal similarities of Rtg proteins with eukaryotic transcription factors involved in development and metabolism.
We performed a candidate gene study in the Framingham Offspring Cohort to evaluate the effect of KL-VS variant of the Klotho gene on valvular calcification.
We performed a case-control study to investigate whether obesity early in adulthood affects risk , age of onset , or outcomes of patients with HCC.
We performed a clinical and experimental study , enrolling @number@ female patients with periocular wrinkles.
We performed a comprehensive geriatric assessment , including information on socio-demographic variables ( family , friendships , and acquaintance contacts ) .
We performed a coordinate-based meta-analysis to compare gray matter changes in Alzheimer's disease ( AD ) and late-life depression ( LLD ) .
We performed a cross-sectional study to investigate these associations in @number@ apparently healthy middle-aged to elderly subjects.
We performed activation likelihood estimation analysis for voxel-based meta-analyses.
We performed a Delayed-Item-Recognition task to investigate the neural substrates of non-verbal visual working memory with event-related fMRI ( 'Shape task' ) .
We performed a feasibility study to evaluate the implementation and effectiveness of a home delivery service providing nutritious meals.
We performed affinity-based enrichment with methyl-CpG binding domain protein followed by high-throughput sequencing ( MBD-seq ) to assay DNA methylation in mouse samples.
We performed a genome-wide association study ( GWAS ) in @number@ individuals of European ancestry with Parkinson's disease ( PD ) and @number@ controls.
We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber.
We performed a local resection in patients with suspected GIST admitted for emergency treatment for GI bleeding.
We performed a logistic regression to measure the effect of adherence to each dietary pattern on the odds of sarcopenia.
We performed a longitudinal data analysis from a cohort of premenopausal women followed to their FMP.
We performed a meta-analysis of existing studies to clarify these potential associations.
We performed an ex-Gaussian analysis on the resulting RTs and report that aging bilinguals performed better than aging monolinguals on the Flanker task.
We performed an interactome analysis using mutant forms of lamin A involved in progeroid syndromes.
We performed anthropometric and clinical evaluations.
We performed an unbiased loss-of-function study in mouse embryonic stem cells ( mESCs ) and identified @number@ lincRNAs involved in the maintenance of pluripotency.
We performed a pilot study with the purpose to evaluate the prevalence of sarcopenia in osteoporotic women with vertebral fractures.
We performed a pooled analysis of eight studies contributing to the International Lung Cancer Consortium ( @number@ cases and @number@ controls ) .
We performed a propensity score match that provided @number@ patients in each group.
We performed a prospective study to determine whether the presence of MBs provides useful prognostic information in healthy elderly individuals.
We performed a proteomics study to identify novel signaling molecules organizing the VSMC hyperplasia.
We performed a PubMed literature search from @date@ to @date@ .
We performed a retrospective case-control study comparing age at onset and disease duration between carriers of ≥1 polymorphism allele and noncarriers for these SNPs.
We performed a retrospective study of @number@ patients with ALM.
We performed a review of the literature to assess the available evidence on the role of nuclear medicine techniques in the diagnosis of PVE.
We performed a review to determine the status of the literature on the potential influence of cochlear implantation on cognition in the older adult population.
We performed a systematical search in EMBASE , PubMed , Web of Science , CNKI and Wanfang databases as of @date@ , @number@
We performed a systematic literature review with the aim of gaining a picture of the prevalence of ARHL in Europe.
We performed a systematic review of randomized controlled trials comparing the efficacy of composite and ceramic inlays or onlays.
We performed a systematic review of randomized controlled trials evaluating the efficacy of interventions targeting PF among ICU survivors.
We performed a systematic review of the literature on the global disease burden due to VTE in low , middle and high income countries.
We performed a systematic review of three scientific databases.
We performed a systematic review to explore the cutaneous effects of each of these three products.
We performed base case cost-benefit analysis and probabilistic cost-benefit analysis with a Monte Carlo simulation.
We performed bilateral TPC modified with a preceding coverage of air leak points with polyglycolic acid sheets for reinforcement.
We performed comparative 2-dimensional immunoblotting of PrP ( C ) charge isoforms in CSF samples from cohorts of diseased and control donors.
We performed descriptive , bivariate , and ordinal logistic regression analyses.
We performed ELISA assays to investigate plasma concentration of total histone @number@ ( H3 ) and the histone modification H3K27me3.
We performed estimates of testosterone , hemoglobin ( Hgb ) , hematocrit ( Hct ) , glucose , creatinine , and lipid profile.
We performed exonic sequencing and validation in two independent cohorts of > 800 subjects.
We performed functional connectivity analysis for @number@ individuals with SCI and @number@ individuals without SCI.
We performed Generalized Estimating Equations population-averaged model using the ten years of panel data.
We performed genome-phenome correlation among @number@ symptomatic HCM patients , @number@ asymptomatic carriers and @number@ non-carriers , using an 18-gene clinical diagnostic HCM panel.
We performed genome-wide association studies ( GWAS ) in @number@ CeAD cases and @number@ controls.
We performed genome-wide association studies of mean LTL in @number@ individuals , with a two-stage replication in @number@ individuals from Chinese populations.
We performed genotyping for the rs6971 TS.PO gene polymorphism to control for the known variability in binding affinity.
We performed GM segmentation followed by regional analysis of volumes examined in normalized space map creation and voxel based morphometry-type statistical inference in SPM8.
We performed group comparisons regarding all cognitive subtests for participants with and without T2DM.
We performed immunohistochemical stainings on frontal cortex , white matter and cerebellar cortex of @number@ healthy controls.
We performed in vivo experiments in mice using lentiviral vectors encoding either Abhd11os or a small hairpin RNA targeting Abhd11os.
We performed in vivo IA dose-response evaluation in our animal stroke model with C57 / Bl6 mice.
We performed morphological and molecular analyses and demonstrated that local over-expression of the AVP receptor V1a enhances regeneration of atrophic muscle.
We performed multivariable Cox proportional hazards analysis and calculated relative integrated discrimination improvement.
We performed multivariate logistic regression analyses with presence of regular dizziness at 7- and 10-year follow-up as dependent variables.
We performed @number@ right colectomies , @number@ left colectomies , @number@ rectal resections.
We performed oxygen plasma treatment on reduced graphene oxide ( rGO ) to improve its surface reactivity with respect to biomolecular interactions.
We performed permutation-based p-min tests to account for multiple comparisons within each gene.
We performed principal component analysis and multiple regression analysis.
We performed quantitative evaluation of total elastin , collagen types I and III , and newly synthesized collagen using computerized histometric and immunohistochemical techniques.
We performed secondary analysis using data from a case-control study conducted at Dhaka Community Hospital , Bangladesh between April and November of @number@
We performed single-cell analyses of neurons with different vulnerabilities to AD-related changes.
We performed spirometry and gave them their results , FEV RESULTS : Fifty-six percent were women with an average-age of @number@ who smoked @number@ pack-years.
We performed SPSS , chi2 , and logistic regression analyses.
We performed survival analyses using Cox proportional hazards models.
We performed the experiments on AgingPortfolio ( text dataset ) and then rechecked on the Yeast ( nontext genetic data ) .
We performed these analyses separately according to disease , gender , and the nature of the job loss.
We performed the T1w / T2w analysis in cognitively normal elderly individuals.
We performed this meta-analysis to derive a more precise estimation of the association between MTHFR polymorphisms and PE.
We performed this study to assess our IPL-ALA-PDT protocol for photorejuvenation in Asian skin.
We performed this study to assess the impact of age on potential differences in clinical characteristics , treatment patterns and outcome in HCC patients.
We performed transthoracic RT3DE and measured the maximum and minimum LAV.
We performed ultraviolet ( UV ) irradiation to induce SAR01 / 04 cell apoptosis which was analyzed by flow cytometry.
We performed whole-exome sequencing ( WES ) in two affected individuals from the 2p23-p16-linked MACOM family , which includes @number@ affected individuals in @number@ generations.
We performed whole-genome sequencing on @number@ supercentenarians to explore the genetic basis underlying extreme human longevity.
We performed within-person trajectory analyses using piecewise regression following nonparametric modeling of functional forms.
We perform several tests of the robustness of the life expectancy model.
We piloted dose-attenuated VCD ( \ "VCD-Lite \ " ) in such vulnerable adults with newly diagnosed MM ( NDMM ) .
We pinpoint stochasticity and noise as important methodological issues for the dissection of TASS isoform patterns.
We plan to recruit @number@ patients with fibromyalgia.
We plan to recruit @number@ patients , with randomisation at physician level.
We plan to take a closer look at the effect of each reinforcement separately.
We plotted trend lines , using regression , and confidence intervals for individual patients.
We pooled data using random-effects models.
We pooled the effect estimates ( hazards ratios [ HRs ] ) under a random effects model.
We posited that association between alexithymia and poorer neurocognition would support the deficit nature of alexithymia in later life.
We posited that distinct combinations of TLRAs and C-type lectin receptor agonists may enhance Th1 responses of newborn DCs.
We posit that physiological fibrosis-like reactions evolved as an essential process in host defense against pathogens and in normal wound healing.
We postulated a specific relation pattern a priori and tested the hypotheses statistically in order to examine the models for equivalency of the factorial measurement.
We postulated that being able to rely on stable autobiographical memories ( intrinsically associated with emotions ) would be a valuable memory aid.
We postulated that higher adiponectin would be linked to increased risk for AF in older adults in a U-shaped manner.
We postulated that SIRT1 may regulate TERT expression via long-range interaction , or via yet unidentified histone modifications.
We postulated that testosterone ( T ) in men and estradiol ( E2 ) in women govern unstressed cortisol-mediated negative feedback on ACTH secretion.
We postulate that an increase in the bioavailability of curcumin should be introduced very carefully considering senescence induction as a side effect.
We postulate that a similar endothelial aging may contribute to the increased rate of CVD seen in populations chronically exposed to low-dose-rate radiation.
We postulate that biomechanical forces and inflammasome activation , together with ischemia and aging , may play a role in pressure ulcer development.
We postulate that change in myelin lipid composition might be relevant for our understanding of aging and demyelinating diseases.
We postulate that further investigations of methods that are equivalent in animals experiments and observations performed on humans are necessary.
We postulate that vascular ageing could also be relevant in the context of anti-angiogenic therapy.
We predicted that ageist attitudes would interfere with the ability to respond to them with compassion.
We predicted that a remote TBI would compound normal age-related cognitive decline , particularly affecting executive function.
We predicted that cancer would become the leading cause of death around @number@ although sex-specific crossover years varied.
We predicted that problems meeting BN would have a greater influence on CD among those with the APOE epsilon4 allele than those without the allele.
We predicted that QOL in the physical and social domains would be poorer , but improvements would be found in the psychological domain.
We predicted the corresponding aging-progressed weights using a weight-for-age equation adjusted for sociodemographic variables.
We predicted the follow-up PWV decrease using modelled baseline curves and follow-up pressures.
We predict such genes to be aging-related.
We predominantly observed hypermethylation throughout the genome within the aged group as compared to the young subjects.
We prepared oxidized LDL and acetylated LDL from healthy volunteers for the positive control experiments.
We present a 57-year-old male patient with excessive hypertriglyceridemia despite intensive lipid-lowering therapy.
We present a case of an 84-year-old Belgian man , presenting prostate cancer with bone metastases.
We present a case of an old woman who stumbled at home.
We present a case report of an atypical giant pituitary adenoma secreting follicle-stimulating hormone ( FSH ) .
We present ACEt , an R package for fast estimating dynamic variance components and heritability that may change with respect to age or other moderators.
We present a cohort-sequential latent growth model assessing patterns of mean-level change due to both aging and cohort effects.
We present a comparison of the AoA ratings across all languages by contrasting them in pairs.
We present a computerized battery that takes an average of 1h and provides measures of accuracy and speed on @number@ neurocognitive domains.
We present age- and gender-specific normative data for the German AVLT from subjects aged between @number@ and @number@ years.
We present a Health Care Sustainability Framework based on disaggregating the health care expenditure into separate planning components.
We present a historical background to highlight that previously established aspects of phenolic extraction and retention into red wine are still subjects of much research.
We present a mathematical ( ordered pull-through ; OPT ) model of the cell-density profile for the mammalian lens epithelium together with new experimental data.
We present an analysis of qualitative data collected over a one-year period in two distinct AL settings.
We present an autopsied case of a senile Japanese woman with sporadic frontotemporal lobar degeneration ( FTLD ) presenting as frontotemporal dementia.
We present and discuss the current models of traumatic head injury , and we focus on those that assess changes in tau.
We present a new algorithm for reliable , unbiased , multivariate longitudinal analysis of cortical and white matter atrophy rates with penalized statistical methods.
We present a new method using digital volume correlation to map the 3D displacement and strain fields in the LC under inflation.
We present a new unified kernel regression framework on manifolds.
We present an exhaustive revised document focusing mainly in recommendation by age in which some more Scientific Societies have been involved.
We present an interprofessional intervention called CAPABLE-Community Aging in Place : Advancing Better Living for Elders.
We present a novel kernel regression framework for smoothing scalar surface data using the Laplace-Beltrami eigenfunctions.
We present a novel way to determine the extent to which MPH enhances cognitive performance in a certain domain.
We present an update on the pathophysiology , diagnosis , management , and future directions in this disorder in older persons.
We present a prediction score based on information that can be obtained in the primary care setting.
We present ARTSENS , an image-free system for non-invasive evaluation of arterial compliance in-vivo.
We present a theoretical framework to understand group engagement and present measures that could be used in future research and practice.
We present a two-dimensional electromagnetic analysis of light propagation through the human eye to examine the eye's optical properties.
We present a unique crosstalk between a histone modifier and a chromatin remodeler , regulating a coordinated response to prevent DNA damage.
We present criteria for all-cause dementia and for AD dementia.
We present data suggesting that the RNA-binding protein HuD , which represses insulin translation , is displaced by miR-196b.
We present evidence from the scientific literature for age-related genetic and epigenetic alterations leading to cancer and discuss the main challenges in the field.
We present evidence in healthy populations for sex differences-females outperforming in verbal and face memory , and age effects-slowed memory processes with age.
We present evidence relevant to the theory.
We present evidence supporting the use of neuroimaging-based ' brain age ' as a biomarker of an individual's brain health.
We present evidence that bakuchiol , having no structural resemblance to retinoids , can function as a functional analogue of retinol.
We present evidence that , in hippocampal neurons , activation of the Sonic hedgehog ( Shh ) signaling pathway affects multiple aspects of mitochondria.
We present here new data for deciduous crown formation times based on these regression equations.
We present here @number@ patients aged @number@ @number@ and @number@ years referred to genetic consultation for dysmorphic facies and failure to thrive.
We present here results from sixteen New Zealand White Rabbits , which underwent intradermal DNA Aβ42 immunization via gene gun.
We present here three examples of evaluations with a focus on program theories and their links to inequalities.
We present immunohistochemical evidence for the presence of Aβx-34 in the brain of 3xTg mice and Alzheimer's disease-affected human brains.
We present longitudinal data from age @number@ to @number@ years concerning chronic musculoskeletal / joint pain , abdominal pain , and headache.
We present models adjusted for demographic and socioeconomic covariates and also stratified on sex , race , and Southern birthplace.
We present new findings on the low-temperature degradation of yttria-stabilized zirconia at 37°C over several years and at high and low partial pressures of water.
We present normative data from a large population-based sample of centenarians for several brief , global neurocognitive tasks amenable for frail elders.
We present novel features based on the inter-regional covariation of cortical thickness.
We present @number@ cases of early-onset Alzheimer's disease due to a novel N135Y mutation in PSEN1.
We present our experience with clomiphene citrate treatment in patients with LOH and a review of the literature.
We present our latest work on in vivo skin capacitive imaging analysis by using grey level co-occurrence matrix ( GLCM ) .
We present our observational data using a simplified regimen of coadministered tPA / DNase.
We present our view of the role of shared medical decision-making to combat global underutilization of oral anticoagulation for stroke prevention in atrial fibrillation patients.
We present potential explanations for these findings and suggestions for future trials involving similar populations.
We present preliminary results pertaining to the incidence of falls in patients with advanced cancer from an ongoing study of risk factors for falls.
We present projections of cancer incidence rates and cases for the period up to 2015-2019 in Switzerland.
We present protein-related nutrition concepts , including adaptation to starvation and stress , anabolic resistance , and potential adverse effects of amino acid provision.
We present results regarding the testing of the coated microchannels after extended periods of aging and blood exposure.
We present simulations results and a subgroup analysis from parallel-group , placebo-controlled randomized trials of antibiotics for acute otitis media.
We present studies of HTS DNA folding in an anhydrous , high viscosity deep eutectic solvent ( DES ) comprised of choline choride and urea.
We present study design and methods for MI Values as well as data on feasibility of recruitment methods and treatment integrity.
We present suggestions for dealing with missing MMSE data based on the extent of missingness and the goal of analyses.
We present the analytical evaluation of the newly developed Philips Minicare cTnI point-of-care immunoassay.
We present the case for differing relationships between aerobic glycolysis and oxidative phosphorylation across primates in association with species-specific variation in neurodevelopmental trajectories.
We present the clinical response data from @number@ phase II / III clinical trials based on age stratification into young and old subgroups.
We present the predominant theoretical models of awareness and summarize both traditional and emerging approaches to assessing awareness from clinical and meta-cognitive perspectives.
We present the prevalence and determinants of visual disabilities and status of cataract among citizens aged @number@ years and older.
We present three cases of green nails in elderly persons.
We present two cases of prototypical patients benefiting from the program , and also provide preliminary empirical support for the effectiveness of this group program.
We present valence and arousal ratings for @number@ Finnish nouns for a sample of @number@ Finnish speakers.
We presume that aggregation of abnormal proteins and autophagy dysregulation in the myocytes of GNE myopathy could induce granuloma formation.
We presume that the lack of positive effects on primary outcomes is due to programme failure and not to theory failure.
We previously characterized a 177-kDa allergen , M-177 , from Dermatophagoides farinae.
We previously demonstrated that apple extracts have anti-ageing effects in this organism because of their antioxidant properties.
We previously demonstrated that changes in N-glycans alter Aβ production.
We previously demonstrated that ( COMT ) is transcriptionally regulated by estrogen via estrogen receptor ( ER ) .
We previously demonstrated that dendritic MSN spines are lost in aged corticostriatal co-cultures from YAC128 mice.
We previously demonstrated that hSKPs senesced quickly under routine culture conditions.
We previously demonstrated that topical surface application of BoNT A has negligible cutaneous bioavailability and is not effective in treating wrinkles.
We previously developed and validated an upper-extremity function ( UEF ) assessment method that incorporates wearable motion sensors.
We previously examined gaze anchoring during a two-segment eye-hand task under a low accuracy constraint.
We previously found that administration of an anti-tau antibody to human tau transgenic mice increased the concentration of plasma tau.
We previously found that DRAM1 increased autophagy flux by promoting lysosomal acidification and protease activation.
We previously generated null and partial loss-of-function alleles of cac , the homolog of CACNA1A in Drosophila.
We previously identified a @percent@ age-related decline in mitochondrial DNA ( mtDNA ) copy number in isolated human islets.
We previously identified a potent and specific calpain @number@ peptide inhibitor ( CYGAK ) , but it was not efficacious in cells.
We previously identified loss-of-function mutations in KRT5 but were only able to detect pathogenic mutations in fewer than half of our subjects.
We previously quantified frailty in aged mice with frailty index ( FI ) that used specialized equipment to measure health parameters.
We previously raised mAb against several synthetic peptides of hVASH1 , and found that one of them exhibited neutralizing activity against hVASH1.
We previously reported early outcomes of a cohort of patients treated with a Grammont-style RTSA.
We previously reported @number@ types of OPTN mutation in Japanese ALS subjects.
We previously reported our short-term findings for dry and wet age-related macular degeneration ( AMD ) patients.
We previously reported potent quinoline-based PDE5 inhibitors ( PDE5Is ) for the treatment of Alzheimer's disease ( AD ) .
We previously reported that APP undergoes palmitoylation at two cysteine residues ( Cys186 and Cys187 ) in the E1-ectodomain.
We previously reported that depsipeptide and its analogs have an additional activity as PI3K inhibitors and are defined as HDAC / PI3K dual inhibitors.
We previously reported that DNA damage down-regulates transcription of ΔNp63αin FaDu and HaCat cells , which contributes to cell apoptosis.
We previously reported that fructose @number@ , 6-diphosphate ( FDP ) , a glycolytic metabolite , alleviates ultraviolet B-induced oxidative skin damage.
We previously reported that High-Mobility Group Box-1 protein ( HMGB1 ) , a prototypic damage-associated molecular pattern , drives MM development and sustains MM progression.
We previously reported that in healthy mouse cerebral arteries , endothelial nitric oxide synthase ( eNOS ) produces H₂O₂ , leading to endothelium-dependent dilation.
We previously reported that miR-127 is up-regulated in senescent fibroblasts.
We previously reported that RORα activates AMP-activated protein kinase ( AMPK ) , which is associated with the suppression of vSMC proliferation.
We previously reported that skin surface electrical potential might be a good parameter of skin pathophysiology.
We previously reported that the hepatic levels of macroH2A1.1 and macroH2A1.2 are differentially expressed in mice models of NAFLD.
We previously reported that the methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphism is associated with homocysteine levels and fracture.
We previously reported that the striatal-specific protein Rhes binds mHtt and enhances its cytotoxicity.
We previously reported that the X-XOD free radical generating system acts as a modulator of lipid metabolism and a mild inducer of apoptotic death.
We previously reported that tumor growth and tumor angiogenesis were augmented in VASH1 ( - / - ) mice.
We previously reported that type L damage preferentially occurs in the case of Japanese females in their 20s to 40s.
We previously reported that α5β1 integrin promotes osteogenic differentiation in mesenchymal skeletal cells ( MSCs ) , but the underlying mechanisms are not fully understood.
We previously showed that ROS enhance miR-200c expression , causing endothelial cell ( EC ) apoptosis and senescence.
We previously showed that the metabolically active areas displayed adventitial inflammation , medial degeneration and molecular alterations prefacing wall rupture.
We previously showed that there is a neonatal arrest of long-term cultured PSC-derived cardiomyocytes ( PSC-CMs ) .
We previously showed that this decline in proliferation is driven in part by postnatal down-regulation of a large set of growth-promoting genes in multiple organs.
We probed the underlying biology of bitter sensing and the efficacy of two known bitter blockers in children and adults.
We produced an MMSE-MoCA conversion table using the equi-percentile method with log-linear smoothing.
We produced antibodies to seven human chromosome @number@ encoded proteins.
We profiled the DNA methylation changes in the blood samples collected at phases @number@ and @number@
We profilometrically measured wrinkle size in four facial areas before and three months after treatment and investigated correlations between wrinkle reduction and patient satisfaction.
We projected that @number@ people have lost PLYs due to back problems in @number@ increasing to @number@ in @number@ ( @percent@ increase ) .
We propose.
We propose a 6-month prerandomization determination of the decline rate or use of an RCD risk score to ensure balanced allocation among treatment groups.
We propose a Bayesian multiple imputation ( MI ) method to impute the unobserved 400-m gait speed for noncompleters.
We propose a completely automated method for BAE based on volumetric hand MRI images.
We propose a conceptual approach to each of these skills also stopping on their cerebral underpinnings.
We propose a graphical method to monitor surgical performance that incorporates risk adjustment to account for patient heterogeneity.
We propose a human-derived neuro- / glial cell three-dimensional in vitro model to investigate the effects of microgravity on cell-cell interactions.
We propose a joint multistate model with latent state for the joint modeling of repeated measures of a quantitative marker , time-to-illness and time-to-death.
We propose a measure of audiovisual speech integration that takes into account accuracy and response times.
We propose a method for automating cell counting and classification in IF microscopy of human postmortem brains.
We propose a method for developing mathematical models for complex systems , based on a genetic programming algorithm.
We propose a method for evaluating CP functionality in vivo using perfusion MR imaging and establish the age-related changes of associated parameters.
We propose a method to extract and use dynamic features for age estimation , using a person's smile.
We propose a model in which PICH recognizes and stabilizes DNA under tension during anaphase , thereby facilitating the resolution of entangled sister chromatids.
We propose an alternative approach of a normal distribution whose scale parameter is conditioned on attained age.
We propose an automated framework for predicting age and neurodevelopmental maturation of a fetus based on 3D ultrasound ( US ) brain image appearance.
We propose a new algorithm for the voxelwise analysis of orientation distribution functions between one image and a group of reference images.
We propose a new registration method that generates a mapping between brain anatomies represented as a multi-compartment model of tissue class posterior images and geometries.
We propose a new reviewing presentation of the tensor threads.
We propose an increase in amino acid transporter expression may contribute to enhanced amino acid sensitivity following exercise in young and older adults.
We propose a novel approach to accommodate the ascertainment process while explicitly modelling the familial relationships.
We propose a novel hyperglycemic , hypoxia-inducible factor ( HIF ) pathway , to complement the current theories regarding hyperglycemic pathogenesis.
We propose a number of clinically feasible approaches to account for the blood pressure effect on PWV measurements.
We propose a possible explanation for these paradoxical phenomena.
We propose a proof-of-concept method for a patient- and disease-specific brain neurodegeneration simulator.
We propose a semiquantitative score to analyse the maturation of the skin surface and a complementary evaluation of the distribution of corneodesmosin and corneodesmosomes.
We propose a technical update on handling such fractures by using locking plates under minimally invasive surgery.
We propose a VOCs fingerprint as a biomarker underlying the physiological mechanisms of aging and longevity.
We propose changes to address these flaws.
We propose directions for future work.
We proposed that treating animals with such compounds would promote protein homeostasis in vivo and increase longevity.
We proposed the LAA isthmus line for potential clinical use.
We proposed this , as an earliest sign on MRI , likely representing early fibro-vascular bone marrow transformation and to our knowledge not previously described.
We propose GHK tripeptide as a possible therapeutic agent against age-associated neurodegeneration and cognitive decline.
We propose health services on a self-organized software platform.
We propose here that MRTFs , YAP and TAZ closely collaborate as mechano-effectors.
We propose HS3ST2 as a novel therapeutic target for Alzheimer's disease.
We propose ideas for preparation of the impending aging burden and the creation of a nurturing environment conducive to healthy aging in China.
We propose Multi-Strategy Coevolving Aging Particles ( MS-CAP ) , a novel population-based algorithm for black-box optimization.
We propose new measures of workload and treatment complexity currently used in our centre that can be easily adopted by other cancer centres.
We propose novel features for training a machine learning classifier that classifies the user's gait into four health problems and a normal health state.
We propose novel , pertinent links to elucidate how the biology of aging affects the sequence of events in the development of LOAD.
We propose original morphological parameters that may prove remarkably useful in the determination of bone maturational stages of the cervical spine in children and adolescents.
We propose pathways through which physical activity acts to buffer stress effects.
We propose several specific suggestions to improve the design of pharmacoeconomic studies in phase III clinical trials.
We propose short peptides Lys-Glu , Lys-Glu-Asp , and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.
We propose that a broader picture of LGI ( notably with elevated pro-inflammatory cytokines ) is required to impact muscle metabolism and mass.
We propose that access to assets and resources is not always sufficient to facilitate resilience.
We propose that a Cdc45-mediated loading guarantees a seamless deposition of RPA on newly emerging ssDNA at the nascent replication fork.
We propose that a CHIP-BACE1-p53 feedback loop might control APP stabilization , which could further be utilized for new therapeutic intervention in AD.
We propose that acute episodes of care are key outcome measures for pharmacoeconomic studies.
We propose that advanced replicative aging is a new unanticipated virulence trait that emerges during chronic fungal infection and facilitates persistence.
We propose that age or stress-related neuronal NAD ( + ) depletion may be a trigger for viral reactivation.
We propose that age-related declines in response reprogramming may be linked to reduced cognitive capacity.
We propose that ALT elongates telomeres across generations but does so at the cost of extensive genomic instability in preimplantation embryos.
We propose that alterations in the expression of these two genes occur early in the pathogenesis of AD in a region-specific manner.
We propose that antidepressant therapy should be initiated first with monoamine oxidase inhibitors only.
We propose that appropriate interventions can strengthen function self-efficacy , thus improving the well-being of elderly persons and their ability to cope with DHF.
We propose that cognitive impairment of cognitive frailty results from physical or pre-physical frailty and comprises two subtypes : the reversible and the potentially reversible.
We propose that cognitive training enhances resting-state neural activity and connectivity , increasing the blood supply to these regions via neurovascular coupling.
We propose that community engagement or \ "participation \ " mediates the relationship between neighborhood conditions and well-being for older African Americans living in Detroit.
We propose that considering these theories can help researchers and developers ensure that technologies will help promote a healthier world for older adults.
We propose that controlling senescence-associated inflammation by targeting specific inflammatory mediators may have a beneficial therapeutic effect in treatment of cancer and aging-related diseases.
We propose that delirium results from a breakdown of brain function in individuals with impairments in brain connectivity and brain plasticity exposed to a stressor.
We propose that dysfunctional AEL vesicles may thus be the source of amyloid-like plaque accumulation in Aβ1-42-expressing Drosophila with potential relevance for AD.
We propose that E2F1 inhibits FOXO3-dependent transcription by directly binding FOXO3 in the nucleus and preventing activation of its target genes.
We propose that early WM atrophy in nfvPPA is suggestive of FTLD-tau pathology while early selective GM loss might be indicative of FTLD-TDP.
We propose that emerging properties of aging C. neoformans cells and possibly also other fungal pathogens contribute to persistence and virulence.
We propose that enhancing glutamatergic neurotransmission by activating the NMDAR may be effective in treating the cognitive decline that occurs in AD.
We propose that epigenetic drift is a determinant of lifespan in mammals.Caloric restriction has been shown to increase lifespan in mammals.
We propose that greater societal wisdom ( including compassion ) may account for the notable increase in average lifespan over the last century.
We propose that H2 functions both as a radical scavenger and a mitohormetic effector against oxidative stress in cells.
We propose that host interactions with microbes are critical for establishing the immune landscape of the lungs.
We propose that ICNs shed their aged and damaged termini and continuously elongate to maintain their density.
We propose that in agreement with the concept of hormesis , a moderate exposure during endothelial maturation to mild physiological oxidative stressors determines -vascular longevity.
We propose that infantile amnesia reflects a developmental critical period during which the learning system is learning how to learn and remember.
We propose that in healthy well-functioning individuals , it taps processes integrating task set establishment and shifting in context of accumulating information.
We propose that , in iteroparous species , relationships between parental age , offspring birth order , and environment may affect selection on senescence.
We propose that interactions between p53 and its isoforms Δ40p53 or Δ133p53 play critical roles in intracellular signaling by reactive oxygen species.
We propose that laboratory animals and semi-wild populations rather than wild animals are suited best to test any hypothesized effect of reactive oxygen species.
We propose that long living species have abnormally high activity of erythrocyte plasma membrane redox system which provides an effective armament to combat oxidative stress.
We propose that mild UPS activation in the young organism will , likely , promote antiaging effects and / or suppress age-related diseases.
We propose that MNKs can modulate oncogenic translation by regulating eIF4E1-eIF4E3 levels and activity in DLBCL.
We propose that movement science is one of the first areas that can productively integrate degeneracy into models of bodily ageing.
We propose that mPGES-1 inhibition in combination with immune cell activation might be part of a therapeutic strategy to overcome the immunosuppressive tumor microenvironment.
We propose that one possible determinant of growth in wisdom from life experience is self-reflection.
We propose that optimization of physiological function throughout the lifespan should be a major emphasis of any contemporary biomedical policy addressing global ageing.
We propose that pathogenic TARDBP mutations have partial loss-of-function properties and that TARDBP p.A90V may increase AD risk by the same mechanism.
We propose that polymorphisms in the regulatory region affect gene transcription , and consequently lifespan.
We propose that post-reproductive life span evolves to stabilize predator-prey population dynamics , avoiding local extinctions.
We propose that redox-dependent quinone formation is the predominant mechanism for formation of PED and PAT drugs from their precursor compounds.
We propose that reduced perforin secretion underlies the reduction in NKCC that accompanies physiological aging.
We propose that regional differences between choroid plexi contribute to dynamic signaling gradients across the mammalian cerebroventricular system.
We propose that responses to periodic virus exposure may drive such expansion , ensuring that the remaining clonotypes are optimized for continued protection.
We propose that resveratrol protects against Wallerian degeneration by activating SIRT1 through dissociation from its inhibitor DBC1.
We propose that some , as yet uncharacterized , aspects of aging are reflected in the appearance of cf-DNA.
We propose that SPRTN protease represents a specialized DNA replication-coupled DPC repair pathway essential for DNA replication progression and genome stability.
We propose that stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase.
We propose that stem cell therapy may be a potent treatment for metastatic melanoma in the brain.
We propose that stress-induced CMV replication warrants further research as a psychobiological mechanism linking stress , aging and health.
We propose that SUMOylation by hPC2 regulates the activity of KDM5B.
We propose that supplementing endovascular thrombectomy with superselective intra-arterial ( IA ) verapamil immediately following recanalization could be safe and effective.
We propose that technology use in the setting of changing environments is motivated by essential needs and tensions experienced by the individual.
We propose that the ability to regulate awareness of unwanted memories through inhibition declines with advancing age.
We propose that the cancer risk alleles act to increase MAP3K1 expression in vivo and might promote breast cancer cell survival.
We propose that the lower serum Klotho level is a newly identified predictor of atherosclerosis.
We propose that the manipulation of CMA could be a therapeutic strategy for HD.
We propose that the musculoskeletal conformation of the modern human mid-foot evolved under selection for a functionally tuneable , rather than obligatory stiff structure.
We propose that the reported mechanisms safeguard healthy ageing in humans through adaptation of the nuclear environment to stress stimuli.
We propose that these changes with age and menopausal status are major contributing factors in the increased prevalence of hypertension in older women.
We propose that this change in sleep regulation is caused by the synaptic pruning that occurs during adolescent brain maturation.
We propose that this low level of senescence might decrease the transforming ability of this factor without totally abolishing it.
We propose that this observation is not confined to memory but can be subsumed under a more general developmental trend.
We propose that this pattern reflects a Hormonal Sensitivity Syndrome.
We propose that this pattern represents functional reorganization caused by reduced efficiency in the MTL network.
We propose that this signature may be incorporated into prognostic assays for monitoring patients on active surveillance to facilitate appropriate courses of treatment.
We propose that three different genes for PD have a common biological function.
We propose that VASH2 would be a novel molecular target for the prevention of EMT in cancers.
We propose that , when the environment is rapidly changing , senescence ( age-related deterioration ) can be altruistic.
We propose the existence of a protein that has a lifespan comparable to that of the whole organism.
We propose the extended skin muscle blepharoplasty to address midface descent and lower lid aging to patients as an alternative to formal midface lifting.
We propose the hypothesis that age-related distractibility is modality dependent , a notion that might need to be incorporated in current theories of cognitive aging.
We propose the RNA population model as a genetic theory of aging.
We propose to determine if elevated leukocyte count was associated with a higher risk of WMLs.
We propose two ' danger zones ' that are particularly vulnerable to tissue necrosis following filler injection : the glabella and nasal ala.
We propose ways of improving the relational autonomy of this population.
We prospectively and longitudinally investigated the effects of weight on arterial stiffness and plasma metabolites in middle-aged subjects ( aged 40-55 years ) .
We prospectively assessed long-term ART effects on the physical and mental statuses of aging men with LOH in Japan.
We prospectively enrolled @number@ children with HGPS ( ages @number@ to @number@ years ) .
We prospectively examined apathy symptoms as predictors of incident slow gait , frailty , and disability among non-demented , community-dwelling older adults.
We prospectively examined BTL measures over time and cancer incidence.
We prospectively investigated the efficacy of an anticholinergic or antidiuretic agent as add-on therapy for nocturia in men previously treated with an alpha-blocker for LUTS.
We prospectively reviewed the records of @number@ patients who had sought evaluation at our hospital with a chief complaint of male climacteric symptoms.
We prospectively studied @number@ healthy subjects ( aged @number@ ± @number@ years , @percent@ females ) without cardiovascular risk factors or neurological disease.
We prospectively studied @number@ PPA and @number@ healthy individuals who underwent extensive cognitive testing and @number@ T MRI.
We proved computationally that the predicted overload behavior was due to substrate competition in the pathway.
We provide a comprehensive review and update of the diagnosis and treatment of glomerular diseases in the elderly.
We provide a conceptual framework for the ever-changing definition of sarcopenia and a rationale for the use of an appropriate rodent model of this condition.
We provide a description of NUMT abundance and distribution in tumor versus matched blood-derived normal genomes.
We provide a mechanism through which 5-HT anorectic potency is maintained with age , via preserved 5-HT-POMC appetitive anatomical machinery.
We provide an integrative genomic and genome-editing toolkit in this organism using our de-novo-assembled genome and the CRISPR / Cas9 technology.
We provide an item bank to compare the difficulty of various physical functioning activities.
We provide an overview of modifiable risk factors for AD along with the supporting evidence.
We provide an overview of ongoing discovery efforts in the genetics of blood pressure ( BP ) and hypertension ( HTN ) traits.
We provide an updated review on the clinical use of NSAIDs for retinal diseases , with a focus on the potential future applications.
We provide a reference map of ARTAG types and propose at least @number@ constellations of ARTAG.
We provide a review of the current literature in assessing possibilities of repurposing medications currently used for non-AD indications.
We provide a structural and functional analysis of human vestibular sensory epithelia harvested at trans-labyrinthine surgery.
We provide a systematic review of studies analysing the conservative treatment options and the natural history of cSDH.
We provide data containing summary statistics for the entire genome , which will be useful for future genetic studies on these injuries.
We provided clinical evidence for the antiwrinkle efficacy of tripeptide-10 citrulline and possibly TEWL.
We provided important suggestions on the future strategies of cancer prevention and control.
We provide estimates of the risk of psychosis onset within clinically defined subgroups of individuals , a tool clinicians can use in treatment planning.
We provide evidence from the literature as well as from our own findings for the roles of repetitive sequences in gene activation.
We provide evidence , from the perspectives of older people themselves , of the ways in which SOC may play a role in that process.
We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.
We provide evidence that suggests intriguing detrimental interactions between stroke and β-amyloid ( Aβ ) toxicity in the hippocampus.
We provide example data from an audiovisual identification experiment and discuss applications for measuring audiovisual integration skills across the life span.
We provide expected score ranges for age groups as a basis for understanding age-related expectations for somatosensory perception.
We provide herein an overview of the BER pathway and discuss the current efforts toward defining the relationship of BER defects with disease susceptibility.
We provide important insights into the lives of women who have partially or fully retired and the changing nature of women's work and retirement.
We provide in vivo evidence consistent with this hypothesis.
We provide possible explanations for this difference.
We provide suggestions on how they can be considered to enhance the validity of CVD models in stem cell research.
We provide tables for converting raw scores to scaled scores in addition to tables with scores adjusted by socio-demographic factors.
We provide theoretical support for human pathology , fracture risk increased with age and the individualized of each age group.
We provide the repertoire of genomic variants that the @number@ octogenarians have in common.
We quantified IQ using the Raven's Coloured Progressive Matrices ( RCPM ) test administrated at age @number@
We quantified neuromuscular control by examining the movement endpoint accuracy and variability , and the antagonistic muscle activity using surface electromyography ( EMG ) .
We quantified @number@ measures of node centrality ( closeness centrality and eigenvector centrality ) to capture the relative importance of individual nodes.
We quantified @number@ ultra-marathon runners ' and @number@ apparently healthy males ' leukocyte telomere length ( T / S ratio ) using real-time quantitative PCR.
We quantified recent consumption at examination @number@ and cumulative consumption by averaging across examinations.
We quantified several mechanical characteristics of individual digits in young and older adults.
We quantified striatal and extrastriatal DA D1 receptor density with [ ( @number@ ) C ] SCH23390 and positron emission tomography in all participants.
We quantified the associations between HDL particle size and HDL efflux using adjusted linear regression models.
We quantified the nucleated cell count , fraction of CD34 + cells , and number of CFU-GM colonies in single aspirates and BM harvests.
We quantified the relative number of astrocytes using the isotropic fractionator technique in combination with SOX9 immunolabeling.
We quantified the resulting echogenicity and investigated its relationship with wrinkle depth.
We quantified transcripts of @number@ known interstitial proteoglycans in human skin and found that decorin was the most highly expressed.
We quantify the impact of these factors on the number of persons with symptomatic knee OA in the early decades of the 21st century.
We quantitatively analyzed the subcellular cytoarchitecture of fast- and slow-twitch muscles from young , intermediate , and aged wt as well as desminopathy mice.
We quantitatively detected hTERT mRNA from study subjects and made each hTERT mRNA normalized ( NhTERT mRNA ) .
We queried whether PDA cells can be reprogrammed to revert to their original quiescent acinar cell state by shifting key transcription programs.
We raise the point of how these emerging needs are faced by the actual research funding.
We randomly allocated them into experimental ( n = @number@ ) and control ( n = @number@ ) groups.
We randomly assigned healthy older adults to train on a verbal n-back task over the course of a month for either @number@ or @number@ sessions.
We randomly assigned @number@ older adults with mild cognitive impairment to either a high carbohydrate or very low carbohydrate diet.
We randomly selected @number@ healthy subjects for each group from a Japanese magnetic resonance image database.
We randomly selected @number@ Ontario adults who were not identified with HIV for each person with HIV for comparison.
We ranked diseases using their average annual notification rate for 2007-2011.
We rated the TPR model as a strong , specialized adaptation of participatory research principles.
We re-analyzed the associations of single nucleotide polymorphisms ( SNPs ) associated with total cholesterol ( TC ) in a large-scale GWAS meta-analysis.
We received @number@ responses.
We received @number@ responses overall ( @percent@ response rate ) .
We recently demonstrated that human ES and iPS cells share similar mitochondrial properties and bioenergetic metabolism , which are distinct from those of fibroblasts.
We recently described that mTOR ( target of rapamycin ) is inactive in contact-inhibited cells.
We recently discovered a unique regulatory B cell subset evoked by breast cancer to mediate protection of metastasizing cancer cells.
We recently established stable daily profiles of the anabolic hormones dehydroepiandrosterone ( DHEA ) and testosterone in @number@ elite military men.
We recently found that phosphorylation of the N-terminal portion of TH triggers proteasomal degradation of the enzyme to increase TH turnover.
We recently identified a novel susceptibility variant , rs865686 , for estrogen-receptor positive breast cancer at 9q31.2.
We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the increased T2D prevalence in Mexico.
We recently identified the Scaffold attachment factor B1 ( SAFB1 ) as a potential interactants in human cells.
We recently identified vibrational spectroscopic markers characteristic of standard glycosaminoglycan ( GAG ) molecules.
We recently reported a therapeutic mitochondrial drug mitochonic acid MA-5 ( Tohoku J. Exp.
We recently reported evidence for maintained early sensory selection when older and younger adults used spatial selective attention to perform a challenging task.
We recently reported genome-wide data on human core promoter STRs that are \ "exceptionally long \ " ( ≥6-repeats ) .
We recently reported impaired angiogenic activity of endothelial colony-forming cells ( ECFCs ) in this condition.
We recently reported that ADAR2 edits and stabilizes nuclear-retained Cat2 transcribed nuclear RNA ( Ctn RNA ) .
We recently reported that VASH2 is expressed in certain ovarian cancers and promotes tumor growth through angiogenesis.
We recently reported the presence in tumor cells of a novel hypoxia-induced form of VDAC.
We recently showed that many of the Zn ( 2 + ) transporters are expressed by the retinal pigment epithelial ( RPE ) cells.
We recently showed that plasma 3-hydroxykynurenine ( HK ) was elevated at low PLP concentrations.
We recently showed that Shh and its signaling components , Patched and Smoothened , are expressed in postnatal and adult hippocampal neurons.
We recognized that @percent@ of the patients were able to fill in the questionnaire by themselves.
We recommend absolute threshold shifts and reductions in slope. @url@
We recommend additional research into the implications of Medicaid eligibility pathways and employment barriers for youth with nonsevere disabilities.
We recommend against using deferasirox in haematological patients outside clinical trials , and marginally support a recommendation for deferasirox in diabetic patients.
We recommend analytic methods for cross wave differences in HbA1C and steps to ensure cross wave comparability in future studies.
We recommend conducting longitudinal cohort studies to explore interventions that may mitigate adult obesity and chronic conditions among poor , rural older adults.
We recommend liberal c-spine imaging for older trauma patients with significant mechanism of trauma.
We recommend models which allow for cross-loadings.
We recommend policy-makers consider appropriate compensation to assist PSWs in effectively executing shifted tasks.
We recommend revising QOL instruments used in cancer care and research to include questions about participation in activities.
We recommend revising the wording of the first item of the SWFL in order to relate the statement with the person's life.
We recommend routine assessment of traditional CVD risk factors within HIV care and treatment programs in sub-Saharan Africa.
We recommend second- / third-generation cephalosporins , amoxicillin / clavulanic acid , azithromycin and respiratory fluoroquinolones as initial choices.
We recommend systematic to transparently report these relevant characteristics of older participants included in RCTs.
We recommend T assay in all men with ED not responsive to PDE5i.
We recommend that a diagnosis of CS be considered an absolute contraindication to the use of metronidazole.
We recommend that all patients with automatic drug dispensing should have a thorough medication review by pharmacists and prescribers.
We recommend that all people with DS with unusual sleep postures should be checked for the presence of SDB.
We recommend that lumbar punctures for clinical and research purposes in Alzheimer's disease be conducted with @number@ gauge atraumatic needles.
We recommend that multi-component interventions could be considered for implementation by practitioners to help improve work participation in older workers.
We recommend that the SAPS II be used for outcome prediction and risk stratification in adult HPVG patients in the ED.
We recommend the development of guidelines on the management of behavioral emergency in the elderly patients , including de-escalation strategies and standardized psychotropic guidelines.
We recommend the use of low-molecular-weight heparin or low-dose unfractionated heparin as the antithrombotic agent after lung cancer surgery.
We recommend the use of NIMV in such patients to avoid unexpected ventilator failure.
We recommend the use of this indicator to monitor the health of the elderly.
We recommend using Cytoflavin together with the standard therapy in treatment of ISAH , which provides the action of geroprotectors for cardiovascular system.
We reconsider the roles of age and TTD by controlling for disability and co-residence and illustrate their relevance for projecting LTCE.
We recorded EEG while adults and 10-year-olds used cues to guide attention before encoding or while maintaining items in VSTM.
We recorded information on patient demographics and risk factors of osteoporosis.
We recorded multiphoton second harmonic generation and nuclear fluorescence signals in single muscle fibers to compare aging-related effects in all genotypes.
We recorded prestin activity by whole-cell patch clamping HEK cells transiently expressing prestin and mouse outer hair cells.
We recruited individuals who had completed the @number@ California Health Interview Survey and were willing to be re-contacted for future studies.
We recruited @number@ community-dwelling adults aged > 65 years and their body composition was measured by dual-energy X-ray absorptiometry.
We recruited @number@ healthy centenarians ( @number@ males , @number@ females , range 100-105 years ) .
We recruited @number@ healthy male Spanish Caucasian individuals and determined their mitochondrial haplogroup.
We recruited @number@ healthy volunteers , aged 18-85 years.
We recruited @number@ MCPH families in Pakistan and could identify the genetic cause of the disease in @number@ of them.
We recruited @number@ older adults with dementia and @number@ without dementia.
We recruited @number@ older Black adults living with HIV from the southeastern United States in @number@ and @number@
We recruited @number@ patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging , PiB-positron emission tomography , and neuropsychological testing.
We reevaluate current evidence for compensatory functional reorganization in the light of recent moves to address these challenges.
We refer to the measures obtained through RQA and CTM methods by dynamical measures.
We refer to them here as monogenic causes , insofar as the genetic abnormality has a readily detectable , large effect.
We refer to this pattern of musical cultural transmission over generations as cascading reminiscence bumps.
We refined MOVES using principal components analysis and Cronbach's alpha and weighted items so each domain was @number@ points.
We refine these trajectories by jointly modelling attrition , since older people tend to leave longitudinal studies ( attrite ) not at random.
We reflect on our experiences in two projects in which we developed interoperable telemedicine applications for the aging population.
We registered terminations of test due to frank syncope or unbearable presyncopal symptoms.
We related cognitive and MRI measures to risks of incident stroke and AD ≤10 years of follow-up.
We related potentially relevant physiological characteristics to beat-to-beat , ambulatory , and day-to-day BP variability to identify underlying mechanisms and potential therapeutic targets.
We relate fluid intelligence and multitasking to multiple brain measures , including grey matter in various prefrontal regions and white matter integrity connecting those regions.
We relate these observations to different models of evolution including the evolution of senescence and suggest that probiotics be selected based on patient age.
We remain reserved about expectations for fully developed AD-like pathology in the great apes of advanced ages and cautiously support Rapoport's hypothesis.
We removed one ovary from patients with POI and treated them with Akt stimulators.
We removed the buried bumper with external traction and placed a new percutaneous endoscopic gastrostomy tube in a different site because of the peristomal infection.
Were observed a decrease of self-efficacy to prevent falling , and falls prevalence was @percent@.
We repeated all data analysis , without excluding depressed participants , without any change in overall findings.
We repeated cognitive and motor tests and gait and balance evaluation after stable dosage of dopamine agonist before and after introduction of AchEI.
We repeatedly measured methylation at multiple CpG sites within each gene's promoter region and calculated the mean of the position-specific measurements.
We repeated the analysis in women with surgical menopause.
We repeated the survey in @number@ to consider whether the situation had improved.
We replicated previous observations that homozygosity for the 371Val allele was associated with higher BMI in white males ( P = @number@ ) .
We replicated the effect of the low functioning MAOA genotype on heightened aggression , which was mediated by greater negative urgency.
We replicated the functional reactivation of STS during the preview period , specific to scenes previously paired with faces.
We replicated this inverse BC-TeloAA association in the Normative Aging Study , a male cohort based in the USA.
We replicate prior work on telomere length and psychopathology and show that this effect is not secondary to medication use or comorbid medical illness.
We replicate these findings in the Copenhagen City Heart Study.
We replicate these findings using whole genome bisulfite sequencing , comparing epidermis from an additional set of younger and older subjects.
We report a 4-year-old boy who presented with clinical manifestations of progeria.
We report a case of buried bumper syndrome as a late complication of percutaneous endoscopic gastrostomy placement.
We report a case of dedifferentiated chondrosarcoma of the chest wall.
We report a case of posttraumatic primary cutaneous aspergillosis and Candida guilliermondii coinfection in a 70-years-old healthy man.
We report a case of purple urine bag syndrome , associated to Streptococcus agalactiae urinary tract infection , progressing to septic shock and death.
We report a diagnostically challenging case of a 64-year-old man with a history of remote head trauma who developed mild behavioral changes and dyscalculia.
We report a Japanese family with HDLS.
We report a Japanese patient with Creutzfeldt-Jakob disease ( CJD ) with a V203I homozygous mutation of the prion protein gene ( PRNP ) .
We report a large genome-wide association study of both sexes including @number@ individuals for AFB and @number@ individuals for NEB.
We report a low level of correlation of gene expression from previous studies of aged muscle with our current analysis of DNA methylation status.
We report an autopsy-verified case of steroid-responsive encephalopathy with convulsion and a false-positive result from the real-time quaking-induced conversion ( RT-QUIC ) assay.
We report a new case with additional histopathologic features not previously described.
We report an investigation of aging and individual differences in binding information during sentence understanding.
We report an isolated , slowly progressive , pure amnestic phenotype in a 59-year-old member of a family affected by autosomal dominant familial Alzheimer disease.
We report a novel presenilin-1 ( PSEN1 ) mutation , I202F occurring in a Welsh kindred with familial Alzheimer's disease.
We report a novel strategy for studying synaptic pathology by concurrently measuring levels of four SNARE complex proteins from individual brain tissue samples.
We report a patient who presented with hematemesis due to cirrhosis of liver and was subsequently diagnosed with Werner syndrome.
We report a patient with GNE myopathy with a homozygous mutation ( c.1505-4G > A ) in GNE gene.
We report a performance deficit associated with a physically healthy aged group compared to young adults specific to trials with low mnemonic interference.
We report a rare case of contralateral delayed hematoma in the context of CAA secondary to acute ICH after AT for intracerebral ischemic stroke.
We report a regression-based method for assessment of frailty using inertial sensor data obtained during TUG.
We report a systematic RNAi longevity screen of @number@ Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age.
We report change-of-function SRSF2 mutations.
We report changes in agitation outcomes in the placebo arm of a recent trial of citalopram for agitation in Alzheimer's disease ( CitAD ) .
We report changes in synaptic function in aged APPPS1 mice not observable in the younger cohort.
We report data from the @number@ consecutive evaluations in @number@ individuals at the Osteoporosis Clinic from @date@ through @date@ .
We report descriptive statistics for QoL , the most important QoL domains for residents , completion rates and experiences of administering the instruments.
We report down-regulation by BM of NO and TNF-α in stimulated RAW @number@ macrophages and of IFN-γ in stimulated human blood cells.
We reported a 41-year-old man suffering from sudden choreodystonic movements and undiagnosed hyperglycaemia.
We reported age-related differences in the microstructural organization of several , specific frontal fiber tracts , but found no correlation with education level.
We reported it to improve life history traits and to suppress neurodegeneration as well as induced apoptosis in Drosophila.
We report evidence for \ "representational rigidity \ " in older adults ' dentate / CA3 that is linked to behavioral discrimination deficits.
We report evidence of a novel pathogenetic mechanism in which thyroid hormone dysregulation contributes to dementia in elderly persons.
We report evidence that a GTPase-activating protein , p190-A RhoGAP ( p190 ) , is a potential molecular target for the treatment of lung adenocarcinoma.
We report findings about job placement and starting wages for hourly workers hired at a women's apparel retailer from @date@ to @date@ .
We report first Indian experience of Core Valve ( Medtronic Inc. ) implantation in three high surgical risk patients performed on 22nd and @date@ .
We report for the first time significant regional variations in the strains that are consistent with the pattern of optic nerve damage in early glaucoma.
We report here analysis of the first year of data focusing on the immune system.
We report herein @number@ cases ( siblings ) with Cockayne syndrome type A confirmed by biochemical and molecular assays.
We report here on the recommendations of the IOM report and the implications for the palliative care community.
We report here on what worked , what didn't , and what we learned along the way.
We report here that A53T α-synuclein mice exhibit greater susceptibility to paraquat.
We report here that depletion of FAHD1 from human endothelial cells inhibited mitochondrial energy metabolism and subsequently induced premature senescence.
We report here that pridopidine and the chemically similar S1R agonist 3-PPP prevent MSN spine loss in aging YAC128 co-cultures.
We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis ( P.g. )
We report here the development of a face discrimination test , in which both response times ( RTs ) and accuracies are measured.
We report here the development of a method for measuring and comparing proliferative capacity of peripheral blood and gut colorectal mucosa-derived CD8 T cells.
We report here the first biochemical characterization of human CTC1 mutations.
We report how cognitive training can improve dual-task management and we attempt to define the cognitive mechanisms that may be responsible for better postural balance.
We report IJV hemodynamic parameters across a large population , which could be used as a normal reference for clinical and research purposes.
We report key demographic , laboratory markers and self-reported comorbidities by HIV status.
We report new examples of lipoic acid ( LA ) -peptide conjugates , their potential as codrugs having anti-melanogenic and anti-aging properties was evaluated.
We report norms for the NART in a pooled sample from @number@ Australian population-based studies of adults aged 65-103 years.
We report on a 13-year-old boy who has presented with severe visual failure since early childhood in a context of prematurity.
We report on a clinical-epidemiological registry with a capture-recapture rate of > 80% and population-based case-control study in ALS patients in South Western Germany.
We report on a novel pro-inflammatory property of resveratrol which has to be considered in concepts of its biologic activity.
We report on a pilot study examining TLC's feasibility and potential benefits and how caregivers viewed their participation.
We report one gene-based significant association with the HMGN1 gene located on chromosome @number@ ( P = 1 × 10 ( @number@ ) ) .
We report on graph theory-based analyses of diffusion tensor imaging tract-derived connectivity in a sample of @number@ healthy individuals aged 72-92 years.
We report on @number@ well over @number@ years old women ( @number@ and @number@ years ) admitted to the emergency room with chest pain.
We report on such improvements in periocular and nasolabial region , upper lips and perioral tissue , and the jaw line and discuss anatomical background.
We report on systemic differences in health among the LLFS centenarians residing in New York and Boston.
We report on the mechanism by which HSCs attain cycling quiescence by addressing a role for inducible cyclic AMP early repressor ( ICER ) .
We report our experience with daylight PDT in @number@ patients.
We report precision and sensitivity as measures of effectiveness.
We report recent developments in the acute treatment and secondary prevention of ischemic stroke of relevance to clinicians who encounter patients with acute vision loss.
We report serial dopamine transporter ( DAT ) positron emission tomography ( PET ) scanning in a patient with Parkinson's disease ( PD ) .
We report skeletal MR imaging in a two-year-old patient who manifested typical clinical and radiographic features of SMDK.
We report that healthy older adults showed learning impairments in contextual cuing when compared with younger adults.
We report that RAD51 and BRCA2 are dispensable for MiDAS but are required to counteract replication stress at CFS loci during S-phase.
We report that S100 proteins were reduced in patients with chronic rhinosinusitis ( CRS ) .
We report that spatial memory is strongly affected in APPxPS1 females while remarkably spared in males , at all ages tested.
We report that the recombinant C-terminal tail domain of human A- and B-type lamins binds directly to purified actin in high-speed pelleting assays.
We report that the rs3764650T allele that decreases AD risk is associated with increased ABCA7 expression.
We report that the thymic morphology and cell types are evolutionarily preserved in several vertebrate species.
We report that this GA repeat is functional and different lengths of the repeat result in significant alteration in gene expression activity.
We report the 2-year effects of a randomized controlled trial of an intergenerational social health promotion program on older men's and women's brain volumes.
We report the blood pressure and metabolic changes in a very elderly obese with severe OSA after 3-month CPAP therapy.
We report the case of a 50-year-old man who presented with progressive gait ataxia.
We report the case of a 71-year-old man with sagging eye syndrome presenting with strabismus fixus and no myopia.
We report the clinical case of a woman who suffered a proximal diaphyseal oblique fracture of the left femur after uninterrupted 13-year treatment with alendronate.
We report the development of , and make available , the Deary-Liewald reaction time task.
We report the first functional analysis of a MJ / RON protein by disrupting RON8 in T. gondii.
We report the first study of employment after lung transplantation in Germany.
We report the perioperative management of off-pump CABG for a 93-year-old man.
We report the prevalence of spirometrically detected COPD in Korea in @number@ using data from the fourth Korean National Health and Nutrition Survey.
We report the targeted needs assessment , content , and evaluation tools for our geriatric oncology curriculum at MD Anderson Cancer Center.
We report the toxicodynetics in mono-intoxications with oxazepam and nordiazepam.
We report three cases of cutaneous squamous cell carcinoma that were treated with Mohs ' chemosurgery for palliative purposes.
We report three cases of elderly patients with acromegaly aged @number@ @number@ and @number@ years respectively with a literature review.
We report three studies comparing the correlations of young and older adults in a broad range of episodic memory and executive function tasks.
We report toxicity and efficacy of the study treatment.
were serious.
We restricted analyses to families with follow-up and complete phenotype information , including @number@ NIA-LOAD / NCRAD and @number@ EFIGA families.
We restricted our review to studies involving only human subjects and excluded studies on type @number@ diabetes mellitus or non-classified diabetes.
We retained @number@ studies that met our selection criteria.
We retained the general framework of probable AD dementia from the @number@ criteria.
were treated with anti-thyroid drugs.
We retrieved @number@ newspaper and magazine articles about later life online dating that were published between @number@ and @number@
We retrospectively adjudicated PD cases identified through @date@ , using multiple data sources.
We retrospectively analyzed data from @number@ ears.
We retrospectively analyzed data of @number@ elderly patients , each with an underlying disease , to evaluate peramivir safety and efficacy.
We retrospectively analyzed magnetic resonance imaging scans from @number@ males ( age 8-81 years ) .
We retrospectively analyzed @number@ patients who underwent NOTCH3 gene testing for molecular diagnosis of CADASIL using Sanger sequencing with a tiered approach.
We retrospectively analyzed syngeneic HSCT outcomes and determined ES incidence , risk factors , and prognostic impact.
We retrospectively analyzed the association between G8 score and OS in all patients and for each ECOG-PS-categorized group.
We retrospectively analyzed the day @number@ serum hormone levels in @number@ patients ( age range : 20-50 yr ) between @date@ and @date@ .
We retrospectively analyzed the efficacy and safety of patients ≥ @number@ years old with AML treated with FLAG or CLO over the past @number@ years.
We retrospectively collected clinical / geriatric factors and laboratory data , and analyzed their association with outcomes using univariate and multivariate analyses.
We retrospectively explored national data in Thailand for reimbursement of all SE in elderly patients admitted in the fiscal year 2004-2012.
We retrospectively reviewed @number@ consecutive patients with cervical myelopathy who underwent decompression surgery between @number@ and @number@
We retrospectively reviewed @number@ patients who underwent TMVr , and @number@ who died in hospital was excluded.
We retrospectively reviewed our elderly acute care surgery population during the past @number@ years to determine the variables affecting major abdominal surgery outcomes.
We retrospectively reviewed patients who underwent thyroid-related orbital decompression surgery at the Kellogg Eye Center , University of Michigan , between @number@ and @number@
We retrospectively reviewed the surgical outcomes for lung cancer patients with IHD or Af.
We retrospectively studied a cohort of @number@ consecutive alloimmunized patients ( 10-year period ) , showing @number@ to @number@ alloantibodies with @number@ different antibody combinations.
Were used descriptive statistics , frequency distribution and analysis of covariance with adjustment variables , was considered significant p < 0.05.
We revealed that Atxn1 actually interacted with RpA1 and its essential partners BRCA1 / 2.
We reveal that it is not only deposited at Bruch's membrane and along blood vessels , but unexpectedly , it also coats photoreceptor outer segments.
We reveal that lineage of origin significantly influences tumor histomorphology and sensitivity to targeted therapeutics.
We reveal that shorter EIP is genetically correlated with reduced mosquito lifespan , highlighting negative life-history consequences for virus-infected mosquitoes.
We reveal that SPP1 is overexpressed in glioma initiating cells defined by high rhodamine @number@ efflux , sphere forming capacity and stemness marker expression.
We reveal that these DHS A / B outcomes are FGT-1 and DAF-16 dependent.
We review and discuss the evidence for nutritional interventions that may support healthy ageing.
We review a series of experiments which show that implicit and explicit adjustments to a novel visuo-motor gain are additive.
We review behavioral and neuroimaging evidence demonstrating that reduced control can enhance the performance of both older and , under some circumstances , younger adults.
We review contemporary studies that focus on clinical and echocardiographic findings that help to distinguish HFpEF from PAH in the patient with PH.
We review current clinical applications of stem cells and highlight problems encountered when going from animal studies to clinical practice.
We reviewed all clinical trials indexed in Medline that tested HMB supplementation as well as all the experimental data regarding HMB intracellular mechanisms of action.
We reviewed all SSIs within @number@ days of surgical procedures between @date@ , and @date@ .
We reviewed articles on sub-Saharan African people living with HIV ( PLHIV ) > 18 years old , published until @date@ .
We reviewed demographic characteristics , comorbidities , and perioperative course of patients with different forms of primary osteolysis.
We reviewed documents and administered a short survey to study participants to assess perceptions of barriers to pain management.
We reviewed electronic patient charts and extracted data on biochemical parameters ( plasma glucose , serum lipids and glycated hemoglobin ) .
We reviewed @number@ cases with radiologic or histologic confirmation of uncomplicated PD of the spine.
We reviewed @number@ verbatim PCCT recommendations that were made for @number@ unique patients in a Veterans Affairs hospital and available in the electronic health record.
We reviewed octogenarians who underwent lung resection for NSCLC in the past nine years in our Department.
We reviewed patients ' chemotherapy courses to identify toxicities , and used the toxicity tool to score the patients ' outcomes.
We reviewed pre-randomisation data from the first @number@ recruited and subsequently randomised FAST patients.
We reviewed published cross-sectional studies which examined heritability in healthy subjects at different ages.
We reviewed study documents using case study methodology to categorize recruitment methods , examine community partnerships , and calculate study costs.
We reviewed the clinical features in all nine previously reported patients diagnosed with ALG8-CDG with a special focus on their skin signs.
We reviewed the clinical histories , histopathologies , and immunohistochemical staining from these patients.
We reviewed the Electronic Medical Records of patients admitted into HHC from @number@ to @number@
We reviewed the existing literature on early lifestyle interventions in childhood cancer survivors and consider implications for clinical care.
We reviewed the latest advances on cancer surveillance , prevention and control in our country , which may provide important clues for future cancer control.
We reviewed the literature to find some practical advice for health care professionals to do symptom assessments in routine practice.
We reviewed the most recent findings in this rapidly expanding field.
We reviewed the neuronal mechanisms of how healthy old and young adults acquire motor skills as assessed with transcranial magnetic stimulation.
We review findings from laboratory research on age differences in the effects of emotion on cognition.
We review findings from the Rush Religious Orders Study and Memory and Aging Project.
We review findings on neuroplasticity in the aging brain and their relevance for cognitive improvement in patients with neurodegenerative diseases.
We review here briefly the history of parabiosis and discuss its utility to study physiological and pathophysiological processes.
We review herein our current understanding of mechanisms underlying the pharmacological induction of T formation in hypogonadal testis.
We review here the evidence for this approach , focusing on vascular health because of limited data on other outcomes.
We review here the many aspects of PGC-1α function in skeletal muscle , with a focus on recent developments.
We review here the pros and the cons for the respective hypotheses.
We review intervention research documenting change in personality.
We review in vitro and in vivo evidence of neuroprotective effects by these T-type calcium channel blockers.
We review major postmortem and in vitro studies documenting cocaine-induced vascular toxicity.
We review methods designed to better estimate neural activity in stroke populations.
We review nearly a half century of research across seven diverse correlational and experimental domains that historically have had little crosstalk.
We review pathologies studied , scanning protocols and data analysis procedures to determine the range of available methods and their suitability to different pathologies.
We review present knowledge about immunosenescence in the respiratory tract against Gram-positive bacteria , particularly S pneumoniae.
We review progress and problems in research areas whose development may contribute to analyses of such connections.
We review recent biological insights gained from applying bioinformatics methods to analyse and interpret ageing data in different organisms , tissues and conditions.
We review recent data that highlight the importance of such interconnectivity / communication in the aging process , in both progressive decline and longevity assurance.
We review recent findings that suggest that in some people with diabetic CKD there is an uncoupling of progressive increases in AER and declining GFR.
We review recent preclinical and clinical data that support the use of melatonin for stroke.
We review recent research on changes of the cerebral cortex and the hippocampus in aging and the borders between normal aging and AD.
We review several moderators and mediators that may accompany MDD and that may give rise to these comorbid medical conditions.
We review some important mechanisms related to calorie limitation aimed at controlling of metabolic diseases , particularly diabetes.
We review studies of possible transmission in bovine , avian , mouse , and cheetah AA amyloidosis.
We review studies on lip restoration in younger females and present our techniques for elderly women.
We review the appeal of the traditional approach to autonomy in health care and then identify some of the difficulties with this conception.
We review the current evidence linking telomere biology to aging processes and mechanisms leading to longevity.
We review the current recommendations for preoperative cardiac assessment adapted for patients with hip fracture and describe our current triage system for preoperative cardiac consultation.
We review the current treatment paradigms for this condition , the mainstay of which is immediate high-dose glucocorticoid therapy with a gradual dose tapering.
We review the different software tools and databases available to analyze the most widely used CLIP methods , HITS-CLIP , PAR-CLIP , and iCLIP.
We review the evidence around these themes , as well as discuss service pathways and referral routes used by some services in England and internationally.
We review the evidence for the effect of this pathway on longevity with a focus on the genetic studies in humans to date.
We review the extraction into wine and evolution of major phenolic classes of sensory relevance.
We review the financial aspects of health-care reform and the implications for musculoskeletal care in the elderly.
We review the fluxes of lactate in white matter and their significance in brain function.
We review the impact of mitochondrial DNA ( mtDNA ) maintenance and mitochondrial function on the aging process.
We review the latest research on RAS , exercise , and physical function for older adults.
We review the literature on leg movement adjustments and show that it is indeed possible to discern fast and slow adjustments.
We review the literature to evaluate trends in CRC surgery in the geriatric population and the outcomes of surgical treatment.
We review the most widely used.
We review the potential role of impaired drainage of interstitial fluid in the pathogenesis of WMH and PVS.
We review the published literature on rosuvastatin in Chinese people.
We review the recent literature about CKD and its implications for renal surgery.
We review the recent literature concerning structural aspects of hCC related to disease.
We review the recent literature on conventional and novel AMI biomarkers , with special emphasis on circulating microRNAs.
We review the role of contemporary techniques with echocardiography and cardiac magnetic resonance imaging ( CMRI ) in the assessment of diastolic dysfunction.
We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.
We review the somewhat confusing PH nomenclature and the WHO classification system and rationale behind it.
We review the theoretical and ontological status of latent variable modeling approaches to cognitive reserve , and suggest research strategies for advancing the field.
We revisited the changes in the interfollicular scalp.
Werner's syndrome ( WS ) is a rare autosomal recessive disorder , characterised by skin changes prematurely during adolescence.
Werner syndrome is an inherited human progeriod syndrome caused by mutations in the gene encoding the Werner Syndrome protein , WRN.
Werner syndrome is a rare progeroid syndrome caused by the WRN gene mutation.
Werner syndrome is genetically linked to mutations in WRN that encodes a DNA helicase-nuclease believed to operate at stalled replication forks.
Werner syndrome should be considered for the cases of liver cirrhosis when accompanied by the features of accelerated aging.
Werner syndrome ( WS ) is a premature aging disorder characterized by chromosomal instability and cancer predisposition.
Werner syndrome ( WS ) is a rare disorder characterized by the premature onset of several pathologies associated with aging.
Werner Syndrome ( WS ) is a rare inherited disease characterized by premature aging and increased propensity for cancer.
Werner syndrome ( WS ) is characterized by the premature onset of several age-associated pathologies.
Werner syndrome ( WS ) results from dysfunction of the WRN protein , and is associated with premature aging and early death.
Wernicke's encephalopathy and Korsakoff's psychosis are severe unfavorable forms of alcoholic brain damage with poor prognosis.
We sampled 1 / 100 of the elderly population.
We sampled @number@ Chicago Healthy Aging Study participants who underwent a dedicated carotid MRI assessment for lipid-rich necrotic core ( LRNC ) plaque.
We scanned @number@ healthy adults aged 40-70 years , using functional MRI.
We scanned reference lists and contacted experts in the field to obtain further information.
We scanned young and elderly adults , half with risk factors associated with metabolic syndrome twice : Once fasted overnight and once after a preload.
We screened extracts of a propolis sample from Algeria with the aim to isolate compounds able to selectively inhibit this enzyme.
We screened @number@ ALS patients and @number@ healthy controls from India for C9orf72 and ATXN2 repeat expansions.
We screened @number@ consecutive levodopa-naïve PD patients for neuropathy.
We screened @number@ IHC sections from formalin-fixed paraffin-embedded tissue , identifying @number@ cases with section detachment ( @percent@ of the sample ) .
We screened @number@ patients ( @number@ males [ @percent@ ] and @number@ females [ @percent@ ] ) between @number@ and @number@ years of age.
We screened SNCA exon @number@ in @number@ patients without SNCA multiplications ( @number@ with autosomal dominant PD and @number@ with sporadic PD ) .
We screened UBQLN2 for mutations in a final cohort of @number@ Irish ALS patients.
We searched databases and public health national institutes websites for HAV seroprevalence records published between @date@ , and @date@ , with no language restrictions.
We searched Embase.com , MEDLINE ( OvidSP ) , the Cochrane Library , Web of Science , Scopus , Google Scholar , and PubMed.
We searched for epidemiological studies on dementia published in 1990-2013 using PubMed , Scopus , EMBASE , KoreaMed , KISS , and RiCH.
We searched for neuropsychological and demographical predictors of RL impairment.
We searched four electronic databases including PubMed , EMBASE , Cochrane Library , and clinicaltrials.gov.
We searched PubMed , Google Scholar and each program's website for relevant studies reporting the effects of computerized cognitive training on cognitively healthy older adults.
We searched the MEDLINE database ( 1973-2008 ) to identify drugs with anticholinergic properties.
We searched the Medline , EMBASE , PsychINFO and PubMed databases from 1985-2014 for studies containing the requisite information to analyze tool validity.
We searched the PubMed , SciELO , and LILACS databases for articles published between @number@ and @number@
We seek to build an infrastructure that will support new patient-focused technologies designed to more efficiently and effectively support older individuals.
We seek to evaluate the extent to which CD33 genetics in AD and AML can inform one another and advance human disease therapy.
We seek to familiarize geneticists , ecologists and evolutionary biologists with the shortcomings of the methods and the most common mistakes made while analysing TL.
We seek to investigate the associations of metabolic syndrome and its components with subclinical carotid atherosclerosis in older people living in rural China.
We selected age groupings by decade ( @number@ @number@ @number@ @number@ @number@ @number@ @number@ years ) , determining age-specific prevalence estimates.
We selected articles about epidemiology , burden , complications , comorbidities , management , prevention , and recommendations / guidelines.
We selected case reports for AEs as specified in the Medical Dictionary for Regulatory Activities ( MedDRA ) .
We selected five tagging polymorphisms from the IL-1β gene and examined the associations with the WAIS-R scores.
We selected @number@ genes involved in three functions that directly affect cellular aging : cell cycle control , apoptosis , and metabolism.
We selected @number@ internationally recognized supercentenarians who lived between 110-122 years old.
We selected @number@ SNPs in five miRNA-processing genes.
We selected @number@ SNPs in the promoter region of KCNJ6 , which were genotyped in @number@ adult alcohol dependents and @number@ controls.
We selected patients aged @number@ years and over hospitalized for proximal humerus fracture in @number@ without cancer.
We selected proteins that are expressed in the adult brain of Tc1 mice and contain regions of moderate / low homology with the mouse ortholog.
We selected the quartiles of the EQ-5D index variables for the analysis.
We selected variants that had reached genome-wide significance in previous association studies on established risk factors for IS.
We separate for the first time the roles of cognitive and motivational factors in shaping age differences in decision making under risk.
We separately studied infant , child , and adult mortality.
We sequenced all exons and exon-intron boundaries of TMEM230 in Chinese Han population including @number@ patients with PD and @number@ healthy control individuals.
We sequenced CHCHD2 gene in @number@ familial ET patients , @number@ autosomal dominant Parkinson's disease patients , and @number@ normal controls.
We sequenced the coding exons of OPTN in @number@ French patients with familial ALS ( FALS ) .
We sequenced the entire mtDNA genomes of the @number@ subjects using a next-generation platform and employed a complete mtDNA phylogenetic analytical strategy.
We serendipitously found the association of rs6677604 with the same protein at p < 9.29×10 ( @number@ ) .
We set each quarter of a year as a time unit and compared ICS prescription between before and after guideline dissemination.
We set out to determine the characteristics and study objectives of current clinical trials in hematological patients.
We set out to evaluate the frequency of OPTN mutations in a sample of our familial and sporadic ALS cohorts.
We set out to explore stakeholders ' views about the ethical and practical challenges associated with recruiting care home residents into research studies.
We set out to investigate the analogies between the pattern of cerebellar degeneration of a healthy ageing population and cerebellar patients.
We set out to investigate the psychosocial and aesthetic effects of cosmetic make-up in order to better understand why women wear it.
We set out to investigate the role of IL-30 in prostate carcinogenesis and its effects on human prostate cancer ( hPCa ) cells.
We set out to investigate whether telomere length is affected in patients with anxiety disorders in which stress is a known risk factor.
We set up a chemiluminescence-based high-throughput screening assay in order to find small molecules able to interfere with the APE1 / NPM1 interaction.
We shall also mention some of our experiments for finding molecules capable of counteracting the harmful effects mediated by hyaluronan.
We shall discuss here several examples studied in our laboratory , concerning skin , cornea and the venous wall.
We shall review the present situation of biomarkers in nutritional epidemiology as well as the future trends of the new omic biomarkers.
We should administer sustainable and evidence-based physical activity including interventions and infrastructure to improve positive affect and psychological well-bing among the elderly.
We should all have a personal interest in ensuring that drugs used in our old age are truly effective.
We should be screening blood lead levels and history of lead exposure in male osteoporosis.
We should consider this possibility , particularly taking into account that aging subjects are more susceptible to infections.
We should emphasize that basic strategies for network construction and analyses can be transported to any tissue or cell type.
We should have subjected the ED01 records to more error checks.
We should re-evaluate the mechanisms of BP elevation in aging.
We should take NIID into account for differential diagnosis of leukoencephalopathy and neuropathy.
We show an age dependent decrease in T-SH levels and increase in PCO and AOPPs level.
We show analytically that the asymmetric distribution of damaged cellular components reduces the overall damage level and increases the longevity of the cell population.
We showcase how diagnosis acceptance and family decision-making are at the heart of how African American families respond to MCI.
We showed a specific dual-task effect in the condition of verbal fluency.
We showed histogram distributions of LV DTI metrics to establish quality assurance measures.
We showed members of a national U.S. life-span panel a hypothetical scenario about a failing plan that was halfway complete.
We showed no association with flavan-3-ol monomers ( P-trend = @number@ ) or polymers ( P-trend = @number@ ) .
We showed previously that the senescence-accelerated OXYS rats strain is an animal model of AMD.
We showed that BMSCs secrete soluble factors that protect AML cells from Ara-C induced cytotoxicity.
We showed that CAR-T cells from geriatric donors ( gCAR-T ) are functionally impaired relative to CAR-T from younger donors ( yCAR-T ) .
We showed that female fertility was decreased in the biopsied mouse model with an increase in age.
We showed that in kidneys from WT mice , DAP12 mRNA and TREM1 mRNA and protein levels were elevated upon UUO.
We showed that LY379268 incremented sAPPα release from cultured astrocytes by inducing α-secretases expression , whereas it decreased β-secretase levels.
We showed that mRNA level of NOSs was not dependent on age in Wistar and OXYS rats.
We showed that neocortical thickness and surface area are largely genetically distinct.
We showed that @number@ genes had altered basal expression level in LA tissue of AF patients compared with the control group.
We showed that only @number@ hiPSC clones would be sufficient to match more than @percent@ of the @number@ patients in need of RBC transfusions.
We showed that optimal vaccine allocation strategies vary significantly with the demographic burden of dengue hemorrhagic fever.
We showed that presence any of the analyzed conditions significantly increased the risk for co-occurrence of other examined weaknesses.
We showed that previously published risk profiles for Northern European and American populations are also applicable to the Greek population.
We showed that prion pathogenesis was impaired dramatically in aged mice when compared with young animals.
We showed that specific metabolic profiles were significantly associated with each type of mutant.
We showed that TD caused a concentration- and duration-dependent death of iCell neurons.
We showed that the increased TRPV5 activity after sialidase treatment is caused by inhibition of lipid raft-mediated internalization.
We showed that these expression changes are specific for cardiomyocytes and are absent in cardiac fibroblasts.
We show for the first time in humans an association between periodontal disease and brain Aβ load.
We show for the first time significantly lowered lamin A / C expression in bicuspidy.
We show for the first time that miR-526b , an miRNA belonging to C19MC , can target the 377-383 region of the MMP1 @number@ UTR.
We show herein that there is a positive correlation between the number of sons born and C-reactive protein concentrations in 90-year-old women.
We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells.
We show here that caveolae are critical in the induction of this anti-inflammatory senescent state.
We show here that in melanoma cells , expressions of Wnt5A and Klotho are inversely correlated.
We show here that NQO1 protein level is regulated by the E3 ligase STUB1 / CHIP ( C terminus of Hsc70-interacting protein ) .
We show here that p21 is abundant in mitosis and binds to and inhibits the activity of Cdk1 / cyclin B1.
We show here that p63 and p73 are dynamically expressed in the embryonic and adult mouse and human telencephalon.
We show here that the administration of recombinant follistatin ( rFst ) increased muscle mass in mice , but had no effect on prostate mass.
We show here that the binding of a potassium ion to a G-tetrad core is mediated by two alternative pathways.
We show here that the Ub-conjugating enzyme UBE2E3 and its nuclear import receptor importin @number@ ( Imp-11 ) regulate Nrf2 distribution and activity.
We show here that with training , in vivo older females ' tendon is less dramatically modulated than that of males'.
We show higher amplitudes of low-frequency oscillations in AD patients.
We show how evidence contributes to standards of care and to the expansion of Medicare reimbursement criteria.
We show how oculomotor data can be converted into direction- and speed-tuning oculometric functions , with large increases in efficiency over traditional button-press psychophysics.
We show how older men construct depression accounts in which they integrate biological and social factors associated with feeling a loss of control.
We show hyperreactivity of Aβ plaque-associated microglia upon systemic inflammation in transgenic AD mouse models ( i.e. , 5XFAD and APP23 ) .
We show in glial cells that QKI-6 co-localizes with Ago2 and the myelin basic protein mRNA in cytoplasmic stress granules.
We show results for six common cancers with very different prognosis and five different age groups.
We show that accelerated senescence evolves when later-born siblings are likely to experience an environment detrimental to lifetime reproduction.
We show that acetylation at K52 decelerates cervical cancer cell proliferation , suggesting RhoGDIα acetylation to be a promising therapeutic target.
We show that age-related changes in autograft efficacy are caused by a loss in endogenous Wnt signaling.
We show that a haplotype associated with increased PERK activation is genetically associated with increased PSP risk.
We show that , along with age , the volume of left CA3 / dentate gyrus predicts memory performance.
We show that ARIH2 E3-ligase regulates PABPN1 protein accumulation and aggregation.
We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy.
We show that at the stable population size , the structure of the frequency dependent evolutionary game emerges.
We show that bacteria initiate cytoskeleton remodeling in AMϕ through interaction with macrophage receptor with collagenous structure ( MARCO ) , a bacterial scavenger receptor.
We show that BAP1 loss follows M3 occurrence and correlates with a global DNA methylation state that is distinct from D3-UM.
We show that B cells from older subjects show similar Cox-2 protein expression and activity , antibody production and proliferation compared to younger people.
We show that both classes of mtDNA rearrangements are unequally distributed among disorders and their breakpoints have different genomic locations.
We show that cardiac function of proton-irradiated mice initially improves at @number@ month but declines by @number@ months post-irradiation.
We show that catalytically active MMP3 cleaved DJ-1 , and impaired its antioxidant function.
We show that CELF1 competes with the RBP HuR to modulate MYC translation and regulates intestinal epithelial homeostasis.
We show that culturing under pulsatile flow resulted in organized and functional hiPSC derived smooth muscle tissue.
We show that DBC1 levels decrease early in the fasting state.
We show that declining migration is related to a concurrent secular decline in job changing.
We show that disease-causing mutations reduce Brf1 occupancy at tRNA target genes in Saccharomyces cerevisiae and impair cell growth.
We show that dMRP4 expression is elevated in response to oxidative stress ( paraquat , hydrogen peroxide and hyperoxia ) in Drosophila.
We show that GAD67 mRNA labeling is significantly lower in PD compared to control cases.
We show that grafts also contain tau pathology in both types of transplanted patients.
We show that hEXO1 and PCNA co-localize in replication foci.
We show that higher mortality leading to greater availability of organs may in part result from disproportionate risks incurred at the local level.
We show that inactivation of YME1L1 results in increased transfer of mtDNA in the nuclear genome.
We show that in Ironman triathletes , swimming performance trades off with cycling and running performance.
We show that intracerebral injection of preformed fibrils of recombinant alpha-synuclein can seed aggregation of transgenically expressed and endogenous alpha-synuclein in neurons.
We show that intranasally-administered Hsp70 rapidly enters the afflicted brain regions and mitigates multiple AD-like morphological and cognitive abnormalities observed in model animals.
We show that intraperoxisomal redox status is strongly influenced by environmental growth conditions.
We show that introducing delayed effects is equivalent to perturbing adult mortality patterns with a particular class of time- / age-varying frailty.
We show that latent T. gondii infection compromises the management of auditory distraction in elderly by specifically delaying processes of attentional allocation and disengagement.
We show that leptin levels in CSF are unchanged as subjects progress to AD.
We show that life outlook is impacted by this temporal landmark , which appears to punctuate people's mental maps of their life cycle.
We show that light touch contact with the device improves stability , whereas the force tasks decrease it.
We show that loss-of-function mutations in MDH2 are also associated with severe neurological clinical presentations in children.
We show that Marf ( Mitochondrial associated regulatory factor ) , is required for mitochondrial fusion and transport in long axons.
We show that MCM2-depleted cells activate a DNA damage response pathway and generate replication-associated DNA double-strand breaks ( DSBs ) .
We show that MCM8-9 functions in a homologous recombination-based pathway downstream from RAD51 , which is promoted by DSB induction.
We show that mice genetically resistant to mousepox ( the mouse parallel of human smallpox ) lose resistance at mid-age.
We show that minimal protracted oxidative stresses induce complex molecular and physiological alterations in cell functionality.
We show that MSH2 associates with known human replication origins with different dynamics than DNA polymerase ( Pol α ) .
We show that MUC1 activates JNK1 and inhibits cisplatin-induced apoptosis in human colon cancer HCT116 cells.
We show that mutant huntingtin markedly accelerates all of these cellular phenotypes in a dose- and age-dependent manner in cortex and striatum of mice.
We show that neuronal hyperactivity regulates both eTau secretion and Aβ production.
We show that neuropathic symptoms are a common and clinically important , yet infrequently studied feature in the NF spectrum.
We show that one of these antibodies designated 1H6 exhibits strong nuclear staining in most human and murine cells.
We show that overexpression of human thioredoxin ( TRX ) , a redox protein , in mice prevents age-related hypertension.
We show that oxidative stress triggers mitochondrial localization of Cdc48 and this is dependent on Vms1.
We show that p33ING1 triggers a senescent phenotype in a p53-dependent fashion.
We show that p53 is required for both HDAC and PcG to repress Arf expression.
We show that PICH binds with a remarkably high affinity to duplex DNA , resulting in ATP-dependent protein translocation and extension of the DNA.
We show that SREBF1 is expressed in murine and human osteoblasts , as well as in human muscle tissue.
We show that TERRA associates with SUV39H1 H3K9 histone methyltransferase , which promotes accumulation of H3K9me3 at damaged telomeres and end-to-end fusions.
We show that the cognitive and neural bases of autobiographical memory are distinct in both cases.
We show that the cytotoxicity of TARC-PE38 is mediated by the expression of the proprotein convertase , furin.
We show that the displacements produced by the middle-aged participants were more nonlinear in comparison with young participants.
We show that the DNA repair protein 53BP1 is a lamin A / C binding protein.
We show that the human tau insert sequence is sufficient to cause the observed increase in Aβ levels.
We show that the killer function of p53 requires the four DNA binding domains within the p53 tetramer to interact with one another.
We show that the mitogenic effect of Ex-4 requires calcineurin / nuclear factor of activated T cells ( NFAT ) signaling.
We show that the previously reported negative correlation between level of alternative splicing and family size no longer holds true.
We show that the use of these medications for the treatment of cardiovascular diseases is often not supported by scientific evidence.
We show that the α cell regulators Aristaless-related homeobox ( Arx ) and DNA methyltransferase @number@ ( Dnmt1 ) maintain α cell identity in mice.
We show that this htt fragment aggregates in C. elegans in a polyglutamine length-dependent manner and is toxic.
We show that this joint influence can be described by a relatively simple \ "genetic dose - phenotypic response \ " relationship.
We show that this low activity can be reversed by increasing the concentration of cytosolic pyruvate , thus increasing oxidative phosphorylation.
We show that this mutation abrogates MDM2 activity , thereby resulting in enhanced levels and stability of p53.
We show that treatment of cultured cells with CR sera caused increased expression of stress-response genes and enhanced tolerance to oxidants.
We show that tumor suppression by p53 can occur via an alternate route that relies on its interaction with Δ40p53.
We show that , when tested with a classic sequence learning task , requiring individuated finger movements , older adults did not show sleep-dependent consolidation.
We show that young , healthy bone revealed the highest resistance to mechanical loading ( indentation ) along with higher mineralization and preserved osteocyte-lacunar characteristics.
We show that γН2АХ foci induced by an intermediate dose returned back to the control value by @number@ h post-irradiation.
We show the asymptotic rates for the bias and covariance functions of the proposed estimator and its asymptotic normality.
We show the presence of six LRRK2 p.G2019S and nine GBA p.N370S mutation carriers.
We similarly find no evidence of adverse effects of disability discrimination laws on hiring of disabled older workers.
We simulated follow-up images from baseline scans and compared them to real repeat images.
We simulated immobility in @number@ healthy females ( mean age @number@ years ) .
We situate these findings within their social and cultural contexts and discuss social policies that would reduce gender and health inequality.
We sought to approximate frailty phenotype using only administrative claims data to enable frailty to be assessed without physical performance measures.
We sought to assess accuracy of a volumetric method , designed to measure WMH in AIS subjects as compared to the previously validated protocol.
We sought to assess a potential larger role of noncoding nucleotide repeat expansions in ALS.
We sought to assess the clinical characteristics and intravascular ultrasound ( IVUS ) findings of the culprit lesions in elderly ACS patients.
We sought to assess the feasibility of a clustered Randomized Controlled Trial ( RCT ) to evaluate their impact.
We sought to assess the relationship between heart rate variability and baroreflex sensitivity parameters and ambulatory hypertension in a community-dwelling elderly cohort.
We sought to characterize the influence of amiloride and GMQ on the human GABA-A ρ1 receptors using whole-cell patch-clamp electrophysiology.
We sought to clarify the association of the age of transfused blood on outcome in patients undergoing cardiac surgery.
We sought to clarify the im- mediate effects of heating and understand the thermal and short term clinical difference when using these optics.
We sought to compare associations between performance-based , self-report , and proxy report of functional status in centenarians.
We sought to define the genetic loci involved in cervical neoplasia and to assess its heritability using unbiased unrelated case / control statistical approaches.
We sought to derive sex-specific normal values for LV functional parameters obtained using two quantitative methods.
We sought to describe missingness in MMSEs administered in long-term-care facilities ( LTCF ) and to compare and contrast approaches to dealing with missing items.
We sought to describe trends in cancer incidence in Botswana during implementation of the first public ART program in Africa.
We sought to determine chronic conditions and health status in older cancer survivors compared to controls.
We sought to determine gynecologists ' knowledge and attitude regarding sexuality in older women.
We sought to determine if older adults with low levels of baseline inflammation respond to acute inflammation in a manner similar to younger adults.
We sought to determine if the share of HIV / AIDS borne by inmates and releasees in the US decreased between @number@ and @number@
We sought to determine the burden , characteristics , and outcomes of SCA during sports among middle-aged residents of a large US community.
We sought to determine the diagnostic accuracy of MRI for CJD compared to a cohort of npRPD subjects.
We sought to determine the efficacy of interactive tablet-based educational interventions in elderly patients on self-reported knowledge.
We sought to determine the existence of a similar association for non-SAIDs ( NSAIDs ) .
We sought to determine the impact of age-related macular degeneration ( AMD ) on these measures of mobility.
We sought to determine the prevalence of doctor-diagnosed CMC1 OA.
We sought to determine the prevalence of MATR3 mutations in Australian familial ALS ( n = @number@ ) using whole exome sequencing.
We sought to determine the prognostic role of the cardiotonic steroids marinobufagenin ( MBG ) in HF , particularly in relation to long-term outcomes.
We sought to determine these frequencies in a prospectively assessed , community-based autopsy series.
We sought to determine the serum metabolomic profiles associated with progression to and diagnosis of AD in a prospective study.
We sought to determine the specificity of this finding.
We sought to determine whether frequent periodic leg movement during sleep is a risk factor for progression of atrial fibrillation.
We sought to determine whether humans are able to discriminate between body odor of humans of different ages.
We sought to determine whether older adult patients in our own clinic population were able to recall their drug regimens and medical conditions from memory.
We sought to determine whether patients with cancer are at higher risk of recurrent stroke and cardiovascular mortality.
We sought to determine whether racial differences in antilipemic use and lipid control narrowed after Medicare Part D's implementation.
We sought to determine whether structural and geometric changes with age differ in men and women , making women more susceptible to vertebral fractures.
We sought to determine whether such variability has genetic causes and whether genetic variants associated with BP variability are also associated with ischemic stroke.
We sought to determine whether these two techniques yield systematically different results for measurements of inflammation , cellular senescence and adipose tissue composition.
We sought to develop a frailty index in the Physician's Health Study ( PHS ) and estimate the association with mortality.
We sought to develop an animal model of peripheral vascular insufficiency in which microvascular dysfunction and exercise intolerance were defining features.
We sought to develop a relatively simple and fast mouse model of human empathy that resembled these characteristics.
We sought to develop a robust assay to quantify oligomers from CSF.
We sought to elucidate the role of SIRTs in differentiation and proliferation of human neuroblastoma ( NB ) .
We sought to elucidate the underlying mechanisms behind the 20GPPD-induced production of HA.
We sought to establish whether work stressors differentially influence WA in young and aging nursing professionals.
We sought to evaluate differences in arterial stiffness and the role of oxidative stress across the stages of the menopausal transition in healthy women.
We sought to evaluate the association between RMR and EA in African Americans.
We sought to examine associations between IGF1 , IGFBP3 and IGFBP1 with metabolic syndrome in older men.
We sought to examine the association of blood pressure and hypertension with the risk of PD among men and women.
We sought to examine the association of miRNAs with grip strength in a community-based sample.
We sought to examine the characteristics , goals , and outcomes of intergenerational programs for persons with dementia and children or youth.
We sought to examine the link using more objective PI measures.
We sought to examine the relation of plasma cis-vaccenic acid with HF with antecedent CHD.
We sought to examine the relationship between estimated glomerular filtration rate ( eGFR ) and objective physical performance in older adults.
We sought to examine the relationship between novel markers of oxidative stress and arterial elastic properties in healthy humans.
We sought to examine these relationships in the current cART era of reduced antiretroviral toxicities.
We sought to examine whether hepatic arteriolar size , wall thickness , and luminal diameter change with increasing age.
We sought to examine whether the @number@ AHA CVH metrics were associated with calcified atherosclerotic plaque in the coronary arteries.
We sought to explore the use and acceptance of information technology for health among the elderly by reviewing the existing literature.
We sought to further explore the safety and effectiveness of teriparatide for the treatment of osteoporosis in Japanese patients with severe stages of CKD.
We sought to generate data to facilitate forensic facial comparisons.
We sought to identify alcohol use trajectories and correlates of hazardous alcohol use among HIV-infected MSM.
We sought to identify and describe the initial skin and hair findings as potential diagnostic signs of the disease.
We sought to identify emerging research foci with clinical translational potential rather than to provide a comprehensive review.
We sought to identify genes associated with age that are implicated in schizophrenia.
We sought to identify genetic variants in protein-coding regions associated with subclinical atherosclerosis and the risk of subsequent coronary heart disease.
We sought to identify latent classes of smokers based on their day-to-day smoking status in the first weeks of a cessation attempt.
We sought to identify meaningful age-indexed anatomical variables to predict TBAD risk.
We sought to identify predictors of morbidity after surgical treatment of benign prostatic hyperplasia ( BPH ) using a large national contemporary population-based cohort.
We sought to identify the prevalence of falls among stroke survivors and investigate the possible role of the environment in falling.
We sought to identify the situations that older drivers report avoiding ; and , to determine the adequacy of a key measure of such behaviour.
We sought to identify whether the proportion of initially ischemic to eventually infarcted tissue was different between men and women with ischemic stroke.
We sought to improve risk stratification for AF using biomarker information.
We sought to investigate associated geometric changes and then evaluate their clinical characteristics.
We sought to investigate convergent validity of S-FNAME with another memory measure and to identify which demographic characteristics might be associated with performance on S-FNAME.
We sought to investigate how aging influences carotid baroreflex regulation of blood pressure ( BP ) during dynamic exercise.
We sought to investigate if and how aging changes resilience of C. glabrata populations in the host environment.
We sought to investigate imaging correlates of incomplete cognitive recovery among individuals with chronic HIV.
We sought to investigate longitudinal changes in these indicators and their effects on clinical outcomes.
We sought to investigate protein homeostasis in this disease.
We sought to investigate the association between MeDi and MRI infarcts.
We sought to investigate the current BPSD assessment tools being used in RACFs and explore different stakeholders ' views on current practices.
We sought to investigate the differences in tau accumulation patterns between early- and late-onset patients with AD and mild cognitive impairment ( MCI ) .
We sought to investigate the relationships between aging , elevated hemodynamic load , cardiac mechanics , and LV remodeling in an elderly community-based population.
We sought to investigate the role of aldosterone as a mediator of disease and its relationship with the counter-regulatory natriuretic peptide ( NP ) system.
We sought to investigate whether these genetic risk factors are associated with PD age at onset.
We sought to learn how an abnormal concentration of iodide within thyrocyte can have significant effects on the thyroid , specifically the surrounding vascular network.
We sought to provide national estimates of frailty in older people.
We sought to quantify differences in longitudinal brain atrophy rates among older virally suppressed HIV-infected participants compared with that of healthy aging participants.
We sought to review our experience with carotid stenting in symptomatic octogenarians with an emphasis on short-term outcomes and complications.
We sought to systematically review the current literature on FA exercise programs targeted at reducing the risk of falling in older adults.
We sought to test the hypothesis that low IGF-1 concentrations are associated with delirium during critical illness.
We sought to test the hypothesis that the concentration of K + remains constant despite variability in PAC.
We sourced heat wave response plans from several countries that are experiencing a demographic transition that features a growing aging population.
We specifically focus on distinct roles of isoforms and splice variants across the mTOR network.
We specifically looked for instruments which : assess men's health , frailty and fitness ; predict life expectancy , mortality and morbidities.
We specifically searched the COL4A3 / A4 genes and identified @number@ heterozygous mutations in @number@ families ( @percent@ ) .
We speculated that glycitein's anti-amyloidogenic properties are specifically mediated by its binding to Aβ monomers , oligomers and fibrils.
We speculate that beneficial reorganization of the post-receptor neural circuitry occurs in mild but not in severe ROP.
We speculate that drugs and / or therapies that inhibit this physical interaction might be good candidates for reducing cellular senescence and increasing longevity.
We speculate that GBA dysfunction may promote Lewy body formation , resulting in more severe PD or DLB phenotypes that are inherited in families.
We speculate that her relatively high FA may be related to both successful aging and the beneficial effects of exercise in old age.
We speculate that in the PD brain , microglia might undergo abnormalities similar to MDMs.
We speculate that lower antioxidant defenses combined with increased oxidative stress and inflammation may contribute to the adverse outcomes associated with pregnancy in Ob women.
We speculate that muscular decline is partially ameliorated by increased cortical activity-i.e. , increased submental MEPs-so as to preserve swallowing function in healthy older subjects.
We speculate that the adverse effects noted may be due to several possibilities , such as diffusion , injection technique , or intravascular injection.
We speculate that the patients were able to use the spatial information from the retrocue to reduce interference and facilitate binding items to their locations.
We speculate this is due to abrogation of p53-dependent p21 induction , which leads to elimination of anti-apoptotic function of p21.
We standardize the plantar impulse by defining a principal axis of plantar impulse.
We start by describing the space occupied by white matter and techniques used in vivo for its characterization.
We started by analyzing gene expression in the entorhinal cortex of human controls and AD cases with whole-transcript expression arrays.
We started Diabetes Theater , a program for healthcare providers that includes short drama and discussion with attendees , in @number@
We started with developing a model which accurately predicts chronological age.
We start this review focusing on the mechanisms by which anabolic and catabolic hormones may affect physical performance and mobility.
Western blot analyses detected increased levels of BACE1 protein and β-site-cleavage amyloid precursor protein C-terminal fragments in plaque-bearing human and monkey cortex relative to controls.
Western blot analyses were conducted on selected proteins to verify the microarray results.
Western blot analysis and MMP-1 promoter assay revealed that EGCG markedly inhibited heat shock-induced MMP-1 expression in human dermal fibroblasts.
Western blot analysis found no correlation between p53 mutation and expression levels of SIRT1.
Western blot analysis from @number@ human aortas demonstrated significantly higher HOXA4 protein levels in thoracic compared to abdominal tissues ( P < @number@ ) .
Western blot analysis further revealed that GlcNAc markedly suppressed the enhancement of collagen degradation in UVB-exposed HS68 cells.
Western blot analysis of seven DNA damage-related proteins verified this finding.
Western blot analysis was used to analyse the consequences of the CISD2 mutation on the encoded protein.
Western blot analysis was used to verify the changes in αA-crystallin and glyceraldehyde 3-phosphate dehydrogenase ( GAPDH ) levels.
Western blot and cellular immunofluorescence analysis were performed to determine the expression of senescence-associated protein , such as P27 , SKP2 and FoxO3a.
Western blot and immunofluorescence confirmed BET stimulation of osteopontin protein synthesis.
Western blot and immunohistochemistry indicated a remarkable up-regulation of SSTR1 expression surrounding the hematoma after ICH.
Western blot and real-time PCR analyses revealed that DHAvD inhibited UVB-induced MMP-1 and MMP-3 expression.
Western blot assay was compared for p53 , bax , cleaved caspase @number@ rH2AX , and APE1.
Western blot data are presented as a ratio of ER-α or ER-β proteins to β-actin and.
Western blot experiments showed that purified IgG fraction from MS-DAT-positive patients bind to α- and β-spectrin , Band @number@ and Band @number@
Western blot , quantitative polymerase chain reaction ( qPCR ) , and enzyme-linked immunosorbent assay were used to study the levels of AD biomarkers.
Western blots demonstrated reduced aortic expression of senescence markers p16 , cell-cycle checkpoint kinase @number@ and p53.
Western blots showed high-molecular weight \ "smears \ " , particularly for NNT and PRKDC.
Western blots were run on muscle lysates and phosphospecific antibodies used to detect phosphorylation status of targets involved in regulation of FSR.
Western blots were used to investigate the Akt signaling pathway.
Western blotting and enzyme activity assays confirmed the age and species specificities of selected CAR-targeted DPGs.
Western blotting and immunofluorescence analysis showed that PEP-1-FK506BP12 efficiently penetrated chondrocytes and cartilage explants.
Western blotting and immunohistochemistry were used to assess complement fragment deposition in the brain tissue.
Western blotting and immunohistochemistry were used to validate the confidence of proteomic data.
Western blotting , confocal microscopy , and flow sight imaging cytometry assays were used to quantify autophagy flux.
Western blotting showed an increased proportion of type I fibres in Old subjects , and increased amounts of calsequestrin-2 and calsequestrin-like protein.
Western countries are facing a huge increase of hemodynamically relevant cases of aortic stenosis in an aging population.
Western dietary pattern increases the risk of cognitive decline over @number@ years.
Western immunoblots were performed with specific antibodies to ADAM-10 or ADAM-17.
We still do not have a definitive understanding of the mechanism ( s ) of ageing.
West Nile virus ( WNV ) infection is mainly asymptomatic but can be severe in elderly persons.
West Nile virus ( WNV ) is a mosquito-borne enveloped positive-strand RNA virus that emerged in North America in @number@ in New York City.
We stratified the adjusted models by the main variables.
We stratified the participants by hypertensive status to investigate the association between handgrip strength and circulating CD34-positive cells according to hypertensive status.
We strongly recommend that physicians discuss with their patients these potential serious adverse effects of long-term dutasteride therapy prior to instituting this form of treatment.
We strongly suggest employing facilities with multidisciplinary teams for cases involving complex patients at short-term high risk for poor clinical outcomes.
We studied AAT protein derived from human blood using HPLC , SDS-PAGE , and mass spectrometry.
We studied a cohort of normotensive and untreated essential hypertensive Taiwanese participants ( @number@ men , @number@ women , mean age @number@ years ) .
We studied adult age-related differences in the structure of postural variability in manual pointing using the uncontrolled manifold ( UCM ) method.
We studied age differences in these volumes accounting for collinearity and risk factors.
We studied age-related changes in DNA methylation and gene expression in CD4 + and CD8 + T cells from younger and older individuals.
We studied aging effects on the time course of implicit skill consolidation.
We studied a highly conserved podocin phosphorylation site in greater detail and show that phosphorylation regulates affinity of the interaction with nephrin and CD2AP.
We studied all @number@ exons of CHCHD2 and their exon-intron boundary regions.
We studied a possible role of mIndy in human hepatic fat metabolism.
We studied a sample of @number@ women between @number@ and @number@ years old.
We studied a subset with whole-body dual-energy X-ray absorptiometry scans at baseline and during follow-up.
We studied CMI occurrence in @number@ patients with mild cognitive impairment or early Alzheimer's disease ( AD ) and @number@ non-demented individuals on 7Tesla MRI.
We studied collagen XXVIII in zebrafish to gain insight into its structure , evolution and expression.
We studied histologic findings of age-related change in the posterior pituitary gland focusing specifically on abnormal deposition of tau protein.
We studied mitochondrial respiratory capacity and substrate sensitivity in patients with type @number@ diabetes ( patients ) , and obese and lean control participants.
We studied Mm.
We studied morbidity , polypharmacy , cellular and serological inflammatory parameters , and endocrine mediators.
We studied @number@ aged normal ( AN ) subjects , @number@ MCIs and @number@ ADs with PET using [ ( @number@ ) C ] BF-227.
We studied @number@ Caucasian participants ( @number@ females ) aged 45-66years in the Busselton Healthy Ageing Study in Western Australia.
We studied @number@ children aged nine to @number@ years old.
We studied @number@ consecutive patients initially hospitalized in our institution from @date@ to @date@ .
We studied @number@ elderly subjects ( mean age 78 + / -6 yrs , range 69- @number@ @number@ M , @number@ F ) .
We studied @number@ healthy adults aged @number@ to @number@ years ( @percent@ women ) .
We studied @number@ \ "healthy \ " and @number@ unselected Chinese subjects.
We studied @number@ healthy elders , who underwent lumbar puncture at baseline , and serial magnetic resonance imaging scans for up to @number@ years.
We studied @number@ healthy life-long endurance runners , @number@ age-matched untrained controls , @number@ young trained and @number@ young untrained individuals.
We studied @number@ million genetic variants in @number@ people with pulmonary TB and in @number@ healthy controls.
We studied @number@ normal elderly controls ( NEC ) and @number@ probable Alzheimer disease ( AD ) subjects from the AD Neuroimaging Initiative.
We studied @number@ older persons aged @number@ and over in the population-based Singapore Longitudinal Aging Study with diabetes who were followed up over @number@ years.
We studied @number@ overweight ( body mass index > 85th centile ) and @number@ underweight ( body mass index < 15th centile ) children.
We studied @number@ participants ( @number@.9±3.2 ( SD ) ( 83-94 , range ) years old ) per-protocol.
We studied @number@ participants of the Longitudinal Aging Study Amsterdam.
We studied @number@ participants of the Three-City-Dijon cohort , aged 65-80 years.
We studied @number@ participants who reported chronic pain at baseline.
We studied @number@ patients found in both registries ( @percent@ men , mean age @number@ years ) .
We studied @number@ PD patients without LIDs , @number@ PD patients with LIDs , and @number@ healthy control subjects.
We studied @number@ postmenopausal women who visited a health promotion center for a medical checkup.
We studied @number@ PREDIMED participants at baseline and longitudinally ( @number@ years maximum follow-up ) .
We studied @number@ subjects from @number@ cohorts representing @number@ different European countries and the US participating in the MARE Consortium.
We studied @number@ subjects from the Alzheimer's Disease Neuroimaging Initiative database ( @number@ MCI and @number@ cognitively normal subjects ) .
We studied @number@ subjects ' heading direction and speed discrimination using the radial patterns of visual motion in optic flow.
We studied @number@ subjects with biomarker-supported probable AD ( low CSF Aβ Multiple stressors affect developing and adult organisms , thereby partly structuring their phenotypes.
We studied @number@ volunteers without known disease and @number@ patients with cirrhosis by a CRT test.
We studied @number@ young premenopausal ( @number@ ± @number@ yr ) and @number@ older postmenopausal ( @number@ ± @number@ yr ) women.
We studied pathological material from the Rush Memory and Aging Project ( MAP , N = @number@ ) .
We studied protein metabolism and physical fitness in healthy elderly volunteers with slight chronic C-reactive protein.
We studied seven healthy volunteers , who underwent carotid applanation tonometry and aortic cardiovascular magnetic resonance ( CMR ) .
We studied sites that most commonly involved entheses in spondyloarthritis.
We studied the association between alcoholic beverage preference and type @number@ diabetes incidence in persons who reported to consume alcohol.
We studied the association between BP and handgrip strength in middle and old age.
We studied the association between psychotropic drugs and falls in residential care people in order to identify medications that may increase the falls risk.
We studied the association of CMB with risk of incident dementia in community dwelling individuals.
We studied the clinical , histological , immunohistological , and comprehensive genetic features of a series of @number@ pRCC including @number@ pRCC1 and @number@ pRCC2.
We studied the effect of birth size on glucose and insulin metabolism among old non-diabetic individuals.
We studied the effect of resveratrol on cultured human MRC5 fibroblasts , a widely used in vitro model in aging studies.
We studied the effect of Thai dancing on physical performance of Thai elderly.
We studied the effect of these AD-associated molecules on mitochondrial features.
We studied the influence of cultural assimilation on the prevalence and presentation of depressive symptoms in elderly Japanese American men.
We studied the influence of the built environment on the health status of elderly people living in Brussels.
We studied their cortical tissues after SS31 treatment and determined that SS31 crosses the blood brain barrier and reaches mitochondrial sites of free radical production.
We studied their predictive value for future death and disease.
We studied the link between ageing and pulse wave transit time ( PWtt ) indexes at the toe and finger.
We studied the patterns of cortical atrophy across the spectrum between ALS and ALS-FTD.
We studied the relationship between ED and LUTS by univariate conditional Logistic regression analysis.
We studied the relationship between HIF1A and gallstone formation associated with liver steatosis.
We studied the relationship of ah lesions to findings and outcomes in @number@ indication biopsies taken @number@ days to @number@ years after transplant.
We studied the response of Sox2 ( / ) 3 expressing cells to spinal cord injury and their function in the regenerative process.
We studied the safety and feasibility of low-dose rapamycin and its effect on SASP and frailty in elderly undergoing cardiac rehabilitation ( CR ) .
We studied these cognitive processes in patients with Alzheimer's Disease ( AD ) .
We studied the ultrastructure of platelets in the elderly subjects with or without atherosclerosis and healthy young subjects.
We studied three groups of participants : @number@ healthy participants without memory decline , @number@ patients with aMCI , and @number@ patients with mild AD.
We studied transcript levels and protein expression patterns of all known GFAP isoforms in human hippocampal AD tissue at different stages of the disease.
We studied whether a physiological isoform switch of nuclear cytochrome c oxidase subunits contributes to the age-dependent manifestation and spontaneous recovery in reversible mitochondrial disease.
We studied whether increased Medicare expenditures were associated with brain markers of atrophy and cerebrovascular disease in older adults.
We studied whether leukocyte telomere length ( LTL ) is associated with ( HPA ) axis responses to psychosocial stress in elderly adults.
We study DC plan contributions for households with heterogeneous preferences about discounting.
We study the distribution of cortical width given age to predict those patients requiring further investigation for osteoporosis.
We study the effect of secondary education on cognitive performance toward the end of working age.
We study the fibroblast-induced reorganization of the collagen matrix and quantitatively evaluate the effect of Y-27632 , a RhoA-kinase inhibitor , on dermal substitute contraction.
We submitted older adults and young participants to an extensive training of an ecological environment , from both route and survey perspectives.
We subsequently coined the term \ "dynapenia \ " to describe the age-related loss of muscle strength and power.
We subsequently compared procedure outcomes and hospital resource utilization in these patients.
We subsequently investigated the health benefits of Japanese food from different eras.
We subsequently performed reference searches of retrieved articles and available literature was reviewed.
We subsequently postulate on the potential role and strategies in studying HMB in elderly ICU patients to improve muscle mass and function.
We subsequently used RNA affinity chromatography to identify Mbnl1 as a splicing factor that recognizes this enhancer.
We successfully applied this analytical pipeline on @number@ independent Infinium 450k datasets that investigated age-associated changes in blood DNA methylation.
We successfully circumvented this problem by focusing on the critical structural network backbone , using a robust tree representation.
We successfully demonstrated the feasibility of geographically distant physicians to access the SQA instrument.
We successfully monitored systemic inflammation in various tissues of the hIL6-BAC-Luc mice using an in vivo bioluminescence imaging system.
We successfully obtained the bioactive and cell-penetrating fusion protein TAT-Cygb that has the potential application in anti-aging , anti-fibrotic and anti-cancer.
We successfully promoted follicle growth , retrieved mature oocytes , and performed in vitro fertilization.
We successfully reconstructed the oronasal fistula by using the angular artery cutaneous flap.
We successfully replicated all @number@ GRS-lipoprotein associations in @number@ EAs.
We successfully used in-house molecular methodologies for diagnosis and typing , showing HPV and C. trachomatis prevalence consistent to previous reports.
We suggest a modified classification with a mechanism that may distinguish physiological laxity from pathological instability.
We suggest cautiousness when assessing actual LTL attrition due to the need for high-quality DNA and the phenomena of regression to the mean.
We suggested fatigue and depression may depend on the degree of damage of the area.
We suggested that increased levels of reactive oxygen species ( ROS ) produced in the respiration mutants increase HIF-1 activity and lead to this longevity.
We suggest further exploration to determine the clinical significance of this association.
We suggest further training of prison and medical staff for better management of age-related issues in prison can ease the environmental obstacles.
We suggest measuring RV IVAc routinely in patients at risk for RV dysfunction.
We suggest some approaches to research design and analysis that may help increase our understanding of how personality differences may contribute to cognitive aging.
We suggest strategies to optimize the use and acceptance of these devices , which have already entered the market.
We suggest that age-related accumulation of vocabulary is accompanied by enhanced perception of mastery in one's knowledge.
We suggest that age-related decline in fine motor dexterity may in part be responsible for the previously described deficit in sleep-dependent motor consolidation with aging.
We suggest that age-related decrease of the WRN expression but not its common genetic variants might contribute to human immunosenescence.
We suggest that a massive switching of financial and human resources is required to explore the full potential of the human brain.
We suggest that ambulatory assessment ( AA ) is ideally suited for the investigation of the above phenomena and for intervention purposes.
We suggest that a minimal number of dmCpG sites or select sites are required to be altered in order to correlate with gene expression changes.
We suggest that a new avoidance scale is needed and we present a new item pool that may be used for this purpose.
We suggest that , at doses lower than anti-cancer concentrations , pan-mTOR inhibitors can be developed as anti-aging drugs.
We suggest that CKD management should encompass palliative care strategies that promote emotional resilience , sense of well-being , and self-value.
We suggest that conceptual guesses act as \ "stepping stones \ " toward the target whereas lexical guesses simply create retrieval noise.
We suggest that constrained prose recall has considerable potential for the study of long-term forgetting.
We suggest that E2 treatment could be beneficial for stimulating liver regeneration in humans.
We suggest that early music training sets the stage for subsequent interactions with sound.
We suggest that for face-name pairs , feedback may be particularly important for individuals who have relatively poor memory to produce benefits from repeated testing.
We suggest that GFR / Ccr could be used as risk indexes for cardiovascular diseases.
We suggest that higher AGE concentrations in brain tissue and in cerebrospinal fluid might be able to distinguish between normal aging and AD.
We suggest that LF-SQ could be used as an active ingredient for wrinkle-care cosmetics.
We suggest that lower BMI is associated with better functional status in Turkish community-dwelling female older people.
We suggest that management of FTD requires expertise as scientific advances and discoveries about FTD continually change the landscape of care.
We suggest that manipulating brain angiotensin may constitute an effective neuroprotective strategy for Parkinson's disease.
We suggest that measurement of adiponectin concentration and BMI together could be an additional predictive marker of survival among elderly adults.
We suggest that mitochondrial dysfunction , as either a cause or consequence of injury , renders retinal ganglion cells sensitive to degeneration.
We suggest that MMG could be used as an important measurement in studying muscle contraction in age-related sarcopenia.
We suggest that muscle atrophy and down regulation of Ca channels may account for this.
We suggest that novel transgenic rat model for human tauopathy represents a valuable tool in preclinical drug discovery targeting neurofibrillary degeneration of Alzheimer's type.
We suggest that our paradigm of prism adaptation may allow us to quantitatively assess cerebellar motor learning in both normal and diseased conditions.
We suggest that pseudo-hypoxic state is not necessarily caused by mitochondrial dysfunction , but instead mitochondrial dysfunction may be secondary to mTOR-driven hyperfunctions.
We suggest that reduced microglial arborized area may be an aging-related correlate of AD in humans.
We suggest that resveratrol , by dismantling AGE / RAGE signaling on DCs may prevent or reduce increased reactivity to self-molecules in aging.
We suggest that similar adjustments may also be needed for many other large multi-site studies.
We suggest that strategies for optimizing healthy and active aging may help older people to continue participating in the workforce and contributing toward their communities.
We suggest that telomere-independent , potentially maintenance driven gradual induction of cellular senescence during quiescence is a counterbalance to tumor development.
We suggest that the A152T variant is a risk factor associated with the development of atypical neurodegenerative conditions with abnormal tau accumulation.
We suggest that the age-dependent accumulation of mutated mtDNA copies and dysfunctional mitochondria is associated primarily with decreased cellular autophagic and mitophagic activity.
We suggest that the commonly observed trade-offs between early- and late-life reproduction may be mediated by genetic variation in germline stem cell maintenance.
We suggest that the Cu and Fe isotopic fractionation between blood and liver resides in the redox reaction occurring during hepatic solicitation of Fe stores.
We suggest that the degrading effect of age is mediated by deficiencies in temporal processing and central executive functions.
We suggest that the main postural control strategy in children is based on corrections after the beginning of the movement.
We suggest that the wiring and interdependency between subsystems within a network are useful to understand the aging process.
We suggest that they may also be particularly suitable for evaluating the effectiveness of interprofessional working with community-dwelling older people.
We suggest that this analysis has clinical utility and that there is limited room for further improvement using genetic data.
We suggest that this confirms that modern life span extension is driven by delay of death in older life rather than avoidance of premature death.
We suggest that three major drives converging on SC determine the saccade abnormalities in PD.
We suggest that understanding these mechanisms may be important for discovering more sensitive and specific biomarkers for risk , onset , and progression of stroke.
We suggest that , with advancing age , cells become locked into relatively longer-lived response states.
We suggest these results reflect that women have greater perceptual expertise for female faces , facilitating recognition memory.
We suggest the use of age-corrected FEV1 / FVC threshold practicing better than the use of fixed FEV1 / FVC threshold in this patient group.
We suggest to directly address brain IGF-I function in the varying experimental approaches used to confirm that changes have taken place in the desired way.
We suggest to use DLVOTO-relieving medication might reduce pulmonary pressure in this group of patients.
We summarized and evaluated the effect of n-3 fatty acids and MedDiet on cognitive outcomes in a cognitively healthy aged population.
We summarized the data , presented a classification scheme , and proposed a selection of treatment options.
We summarized this view under the label the \ "lost Gemeinschaft \ ".
We summarized updated informations on cancer control policies , conducting network , as well as programs in the country.
We summarize epidemiological evidence on the preventive / therapeutic benefits of exercise and on the main biological mediators involved.
We summarize recent developments that outline these links and hypothesize that clearing cellular damage by autophagy is a common denominator of many lifespan-extending manipulations.
We summarize strategies to circumvent the CD4 T cell defect in aged , including adjuvants and proinflammatory cytokines.
We summarize structural and functional neuroimaging findings associated with gait variability in older adults with and without CI and dementia.
We summarize the current understanding of the close relationship between autophagy and cardiovascular senescence.
We summarize the findings of randomized controlled trials ( RCTs ) and observational studies , grouped according to study design.
We summarize the knowledge about primary and secondary stroke prevention by NOAC in AF patients > 75 years of age.
We summarize the known molecular mechanisms of vitamin D / VDR signaling on autophagy homeostasis.
We summarize the main methods for tear samples analyses and report recent advances in \ "omics \ " platforms for tears investigations.
We summarize the results of @number@ published articles in the WHI with stroke or cognition as outcomes of interest.
We summarize these findings as sexual wisdom.
We summed per capita recruitment and adult survival to calculate estimates of lambda.
We supplemented these data with those of @number@ patients from the United States with clinically probable or possible MSA.
We suppose , that rapamysin , a suppressor of mTOR , causes completely different effects on tumor associated macrophages and cells of microglia.
We surmise that subtle and concerted alterations in the acetylproteome regulate autophagy at multiple levels.
We surveyed orotracheal intubation episodes after more than @number@ years from the initial surgery.
We surveyed third-year medical students , nurse practitioner students and graduate social work students.
We survey the major immunomodulators and neuroregulators in the aging brain and their highly tuned dynamic and reciprocal interactions.
We suspected encephalitis due to Epstein-Barr virus and the patient was treated with acyclovir and high dosage of steroids.
We suspected nosocomial pneumonia together with an exacerbation of the asthma-COPD overlap , and both antibiotics and bronchodilator therapy were initiated.
We synthesized DDQ using retro-synthesis and analyzed its structure spectrally.
We synthesized our results with a meta-analysis specifically testing if length of follow-up was associated with the size of any association.
We systematically analyzed sex-related ACS incidence and ACS-related mortality and risk factors with χ2-squared test , descriptive statistics and survival analysis.
We systematically analyzed the LC in PW.
We systematically reviewed relative effects of Hib vaccine schedules.
We systematically reviewed the literature to determine the level of cognitive functioning of individuals aged @number@ years and older without dementia.
We systematically reviewed the literature to investigate whether smoking reduction therapy can increase the long-term cessation rates of smokers without an intention to quit.
We systematically searched PsycINFO , Ovid and Pubmed for studies evaluating dual task performances of children and adolescents < 18 years of age.
We systematically tested whether neurocognitive speed ( mean rate ) or inconsistency ( intraindividual variability ) was the more sensitive clinical marker of T2D.
Wet-aged subprimals had greater saleable yields than dry-aged.
We tape recorded each session and subsequently used inductive content analysis to identify primary themes.
We tentatively conclude that normal aging dampens the stress-induced link between intrusive thoughts and affect.
We term this process TPE-OLD for \ "telomere position effect over long distances. \ "
We tested a model in which RFL and MIL protect against suicide ideation , controlling for demographic and clinical factors.
We tested and compared the efficacy of pure oxygenated monoterpenoids that are main ingredients of essential oils of good biological activity.
We tested associations using Cox proportional hazard models in sex- and study-stratified analyses and combined results using meta-analysis.
We tested both healthy younger and older adults in a 3-day training session using an orientation discrimination task.
We tested discrimination ability and reclassification of clinical and metabolomic models.
We tested for age-associated changes unrelated to vestibular processing , using a motor paradigm , voxel-based morphometry and diffusion tensor imaging.
We tested for interactions by sex and apolipoprotein E ( APOE ) genotype.
We tested for such interactions in the natively monomeric human eye lens protein γd-crystallin , whose aggregation leads to cataract disease.
We tested haptic recognition , touch detection-discrimination , and proprioception using brief affordable measures as required by the NIH Toolbox.
We tested how baseline levels of Aβ42 and YKL-40 correlated with changes in cortical thickness and cognition.
We tested how older persons satisfy the extra demand in sulfur amino acids induced by long-term paracetamol treatment , focusing on metabolic and nutritional aspects.
We tested if enhancing oxidative stress through diet would accelerate Aβ-related pathology.
We tested kbWF by comparing it with other existing procedures , using simulated functional hemodynamic responses added to real resting-state fNIRS recordings.
We tested models with different hierarchical complexities.
We tested multiple values of the selection parameter in order to produce a model with low deviance.
We tested @number@ English-speaking older adults aged 55-84 , free of stroke and dementia.
We tested @number@ healthy controls ' sera using the same method.
We tested @number@ older ( ages 65-84 ) and @number@ younger ( 20-42 ) adults on a working memory task.
We tested possible relationship between well-being and clinical characteristics including fatigue , depression , sleep disruption and HRQoL.
We tested retention by asking subjects to perform the sinusoidal task ( @number@ trials ) with and without visual feedback.
We tested the anti-aging efficacy of silymarin using the Caenorhabditis elegans model system.
We tested the association between parameters and complications of the disease and FRAX scores.
We tested the association between parental longevity and late-life cognitive decline or dementia.
We tested the effects of aging on the use of prosody to convey meaning and the ability to monitor communicative effectiveness.
We tested the effects of an oral antioxidant treatment ( alpha lipoic acid [ ALA ] ) on AF recurrence post-CA.
We tested the effects of @number@ sleep schedules on daytime sleepiness and whether these effects changed with age in early adolescence.
We tested the hypotheses that higher systemic 11β-HSD1 activity predicts brain atrophy and cognitive decline in older men.
We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people.
We tested the hypothesis that EC senescence increases with sedentary , but not physically active , aging and is associated with vascular endothelial dysfunction.
We tested the hypothesis that feeling alone is associated with the rate of motor decline in community-dwelling older persons.
We tested the hypothesis that genetic variation in the WRN gene was associated with risk of ischemic vascular disease in the general population.
We tested the hypothesis that greater purpose in life is associated with lower risk of cerebral infarcts.
We tested the hypothesis that impaired oxidative capacity affects muscle performance and , through this mechanism , has a negative effect on walking speed.
We tested the hypothesis that impaired rhythmic interlimb ankle and shoulder coordination are risk factors for subsequent mobility limitations among older adults.
We tested the hypothesis that lifelong inhibition of the classical NFκB pathway would protect against aging-related sarcopenia and insulin resistance.
We tested the hypothesis that nonplanning decreases with age and that insula thickness is related to both age and nonplanning impulsivity.
We tested the hypothesis that the biomechanical properties of root dentine change with ageing.
We tested the hypothesis that there is a U-shaped association in older women between cystatin C and risk of incident cognitive impairment @number@ years later.
We tested the hypothesized model of social isolation , including both social disconnectedness and perceived isolation , after SCI using structural equation modeling.
We tested the influence of age on optimistic and pessimistic beliefs about the future and the associated structural neural correlates.
We tested the performance of modified SE using simulated signals and SBF data.
We tested the responsiveness of such dogs in urban areas toward simple human pointing cues using dynamic proximal points.
We tested the variability in cerebrospinal fluid ( CSF ) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms ( SNPs ) .
We tested this haplotype as an expression quantitative trait locus using @number@ different public-access brain gene expression databases.
We tested this hypothesis in a large sample of elderly participants , using a linear discriminant analysis-based approach.
We tested this hypothesis in living humans , using ultra-high field @number@ T MRI to make fine measurements of MTL microstructure.
We tested this hypothesis in @number@ nationally representative panel studies.
We tested this hypothesis using a bigenic mouse in which transgenic expression of APP was restricted to mature projection neurons.
We tested this hypothesis using data collected from preindustrial Finnish church records.
We tested this hypothesis using mouse hematopoietic models.
We tested this hypothesis with a study in which younger and older adults reported their momentary affect on @number@ days.
We tested this pathogenicity screen in SORL1 variants reported in two independent published studies.
We tested this possibility in healthy older adults.
We tested this possibility in @number@ community-dwelling persons aged 20-24 , 40-44 , and 60-64 years using a comprehensive battery of cognitive measures.
We tested trends in counts and standardized incidence rates using linear regression models.
We tested two groups of @number@ observers ( mean age @number@ vs. @number@ ) in an object categorization task.
We tested whether a deficits accumulation frailty index predicted long-term mortality.
We tested whether adherence to a particular dietary pattern was associated with sarcopenia among the elderly in a district of Tehran , Iran.
We tested whether AD pathology was associated with white matter hyperintensities ( WMH ) or cerebral infarcts in the oldest old individuals.
We tested whether decreasing protein intake affects the response to insulin with or without added amino acids , and if this response differs by sex.
We tested whether deficits in perceptual grouping via Gestalt laws ( Gestalt principles of Proximity and Continuity ) might contribute to this decline.
We tested whether higher life satisfaction was prospectively associated with fewer doctor visits.
We tested whether night shifts perturb FR in motor activity and whether night shifts affect FR in chronic shift workers and non-shift workers differently.
We tested whether objective measures of total daily activity decline more rapidly in older adults.
We tested whether senescence of the endothelial cells maintained in in vitro culture can be moderated by their simultaneous exposure to sulodexide.
We tested whether the \ "offspring \ " carry a lower burden of diabetes risk alleles.
We tested whether the tumor suppressor protein p53 ( encoded by Trp53 ) affected this phenotype.
We tested young and cognitively healthy older adults on search tasks indexing speed and attentional control.
We test our approach extensively , including an exploration of spontaneous versus posed smile dynamics , and gender-specific age estimation.
We test our model with two public databases.
We test the hypothesis that summed PCB and DDT concentrations contributed to CDV associated mortality during epizootics.
We test whether this pattern can be generalized to other developed nations.
We thank Jennifer Blank for helping us discover and correct this error.
We , the co-authors , are from two different disciplines , namely Renaissance and medieval literature , and social work and critical gerontology.
We then accounted for the psychosocial factors when examining multiple health correlates of health realism , optimism and pessimism.
We then analyzed codon @number@ polymorphism by Sanger sequencing and compared with previously published results in sporadic CJD.
We then analyzed predictive factors for SDB using their health examination records of the same fiscal year.
We then analyzed retardation as an anisotropic property of adventitial collagen by polarized light microscopy.
We then analyzed the association of these SNPs with the risk of bladder cancer in a large case-control study.
We then analyzed the transcriptional expression profiles of @number@ nuclear receptors at four different passages.
We then applied the approximation approach to explore GWAS summarized in the National Human Genome Research Institute ( NHGRI ) GWAS Catalog.
We then asked whether contactin-2 release induced by BACE1 expression would concomitantly decrease cell surface levels of contactin-2.
We then assessed expected patterns of MOVES in the Canadian population.
We then assessed the association between EFV / FTC / TDF use and health-related quality of life.
We then assessed the impact of the origin of the fibroblast strain on the degree of pigmentation using fetal versus adult fibroblasts.
We then attempted replication in @number@ subjects from the Cohorts for Heart and Aging Research in Genomic Epidemiology ( CHARGE ) .
We then classified all analgesic prescriptions according to the World Health Organization ( WHO ) analgesic ladder.
We then combined fine-mapping , bioinformatics , and bench-based approaches to functionally characterize all candidate causal variants at this locus.
We then compared @number@ AD patients with a control group matched for age , sex and educational level.
We then compare the survival measures with objective measures of health.
We then computed Hedges ' effect sizes and used these to represent the effects of intervention.
We then conducted a clinical trial in females over @number@ years of age , with visible signs of skin aging.
We then conducted an age-period-cohort analysis using the intrinsic estimator approach.
We then conducted bivariate analyses and multivariable random forest and logistic regression analyses to explore factors predictive of cognitive resilience in APOE ε4 carriers.
We then conducted further analyses on the non-demented , non-MCI group , initially stratified by Apolipoprotein E-ε4 gene.
We then conducted genome-wide linkage analysis , and whole-exome sequencing was carried out with samples of two patients.
We then created a simple additive score for these four factors ( present = @number@ absent = @number@ ) .
We then cross-validated our conversion table with the ADNI dataset ( @number@ patients ) and evaluated its accuracy for future predictions.
We then describe deficits associated with schizophrenia.
We then describe various features of WRNIP1 and discuss its possible roles based on recent studies of the function of WRNIP1.
We then determined whether the longevity-associated SNPs were correlated with metabolic parameters in the age group 64-85 years.
We then developed a six-tiered model with proposed interventions to address these barriers.
We then developed statistical models to estimate TDEE by using factors easily obtained during a routine clinical visit.
We then did replication analyses of significantly associated loci in an independent sample series.
We then discuss the neural substrates underlying the entrainment of cognitive and motor processes by music and their relation to affective experience.
We then discuss the potential of combining symptoms-sensitive FDG-PET measures with pathology-specific Aβ-PET to improve the early detection of AD.
We then discuss vascular findings relevant to diagnostic muscle biopsy evaluation , with current theories of pathogenesis and detailed descriptions of the important features.
We then disrupted BSG in three NSCLC cell lines ( A549 , H1975 and H292 ) via ' Zinc-Finger Nucleases'.
We then divided the schizophrenia sample in @number@ subgroups based on a 3-factor model of psychopathology ratings.
We then estimated heritability of the changes in BMD measures between these age ranges.
We then estimate multilevel models to assess how states ' socioeconomic and policy contexts shape the probability of having a disability.
We then evaluated the content validity , reliability , sensitivity and specificity of the Chinese Cantonese MoCA.
We then examined functional status.
We then examined the associations between components of sleep measures and memory scores.
We then examined the effect of RSFA scaling of task-based BOLD in the sensorimotor task.
We then examined the household size equivalised disposable income at the baseline year in relation to the rate of mortality in the following @number@ years.
We then explore biological hypotheses as well as many mathematical models in the literature that attempt to explain these patterns.
We then explored metabolic and inflammatory biomarkers as potential mediators of these relationships ( additive hazards mediation ) .
We then explored the inhibitory effects of apigenin and luteolin on UVA-induced MMP-1 and investigated the molecular mechanism underlying those effects.
We then explored the inhibitory effects of GlcNAc on UVB-induced collagenases and investigated the molecular mechanism underlying those effects.
We then focus on left-side heart disorders that cause PH.
We then found that prednisolone doses alone were significantly associated with serious infections in biologics-treated elderly RA patients.
We then generalize the tools to propose model diagnostics for the proportional odds model.
We then generated a Cox regression model with specific causes of death treated as competing risks.
We then generated a linear regression model with age information and the methylation profile from the @number@ training samples.
We then generated transgenic ( Tg ) mice that over-expressed mouse LRG ( mLRG ) in the brain to examine the effects of mLRG accumulation.
We then highlight factors that potentially modify the muscle damage response following eccentric exercise.
We then highlight multiple factors that could influence these mechanisms of transfer and thus the success of training interventions.
We then hypothesized that a physiological state associated with pigmentary alterations such as photo-aging could be linked to dermal fibroblasts modifications that accumulate over time.
We then identify the degree to which various types of people exist within the networks.
We then illustrate the impact that these changes may have on an adult outcomes : namely , depressive symptoms.
We then impose a Log-Euclidean Riemannian manifold structure on brain functional networks whose norm gives a convenient and practical way to define a mean.
We then interviewed @number@ healthcare professionals working in primary , secondary or intermediate care and involved in the provision of multi-compartment compliance aids.
We then investigated patients with adverse drug events ( ADEs ) or unexpected illnesses transferred to our hospital during the whole year of @number@
We then investigated the mutations in NOTCH3 using direct sequencing within the region of intron-exon boundaries in exons 2-24 of NOTCH3.
We then investigated whether hDSPC-CM has an effect on ultraviolet A ( UVA ) -irradiated NHDFs.
We then investigated whether resveratrol may improve insulin signaling in muscle cells via SIRT1 , or alternative targets.
We then look at how comorbidities lead to increased risk for stroke through BBB disruption.
We then mapped between ages in humans and mice by comparing the age distribution pattern for @number@ diseases in both species.
We then measured microtensile bond strengths and analyzed data with two-way ANOVA and Tukey's tests.
We then measured the expansion of the fusion limit by inserting a middle image in a region located equally parallax from the two images.
We then measured urinary BPA concentration , blood pressure , and heart rate variability @number@ hours after the consumption of each beverage.
We then offer our opinions on the future of advanced medicine with careful consideration of its pros and cons.
We then outline in detail the phenotyping protocol used to acquire comparable data in the parents.
We then outline possible biological explanations for observed empirical associations.
We then performed a meta-analysis using data from a previous GWAS by our group of @number@ CBE patients and @number@ controls of European origin.
We then performed functional annotation analyses of age-associated genes using the Gene Ontology and the Genetic Association Database ( GAD ) .
We then performed mediation analysis to examine whether antiretroviral adherence or body mass index mediates the observed associations.
We then performed murine expression analyses to follow up this finding.
We then performed racial comparisons of positive and negative aspects of caregiving reported by caregivers of black and white stroke survivors.
We then predicted the safety of each compound with an ensemble of deep neural network classifiers.
We then present an extract where the researcher uses a conversational approach during the administration of the same questionnaire.
We then present evidence that after ceasing to reproduce , both men and women provide net economic transfers to children and grandchildren.
We then propose adaptations from the geriatrics literature to better predict both short and long-term outcomes after CRC surgery.
We then propose that taking a temporal view of studying retirement would be most advantageous for psychologists.
We then propose unified models for TFIIH assembly and roles in NER.
We then purposively selected Washington State for our study.
We then put forward a new index Piso , which is a part of fODF to quantify white and gray matter.
We then related individual developmental trajectories to retrospectively assessed self-reported risk-taking and sensation-seeking behaviors during adolescence in a subsample of @number@ participants.
We then replicated @number@ genes in the InCHIANTI study with @number@ participants.
We then review studies that have discovered significant changes in the resting-state microstate series in a variety of neuropsychiatric disorders and behavioral states.
We then show that molecular heterogeneity between telencephalic and hindbrain choroid plexi contributes to region-specific , age-dependent protein secretion in vitro.
We then switched the antifungal agent to liposomal amphotericin B for the treatment of the pulmonary mucormycosis at POD @number@
We then tested Cat316 for restoration of memory in a neurodegeneration model.
We then tested for age , period , and cohort effects using the Intrinsic Estimator approach.
We then tested individual variants for association with disease.
We then tested SNPs previously reported to be associated with either Achilles tendon injury or ACL rupture.
We then tested the interactive effect of GRS , diet and sex on SUA.
We then tested two additional samples of older adults using a between- ( Exp.
We then tested whether combining longitudinal VACS index values at different time points improves prediction of mortality.
We then tested whether the training had an effect in reducing susceptibility to a multisensory illusion , the sound induced flash illusion.
We then tested whether this mechanical stimulus had an anti-aging effect in vivo.
We then used a random-effects meta-analysis to summarize the M , A , and θ , and their @percent@ confidence intervals ( CI ) .
We then used factor analyses to empirically derive dietary patterns for separate waves.
We then used neuropathological and clinical outcomes to determine whether there were any correlations.
We then used RevMan @number@ to determine the sensitivity , specificity , and @percent@ confidence intervals.
We then used these data to calculate the parameters that reflect the nature of SSTM including the skin ridge number using originally developed software.
We then use epigenomic profiling to identify enhancers associated with the quiescent NS cell state.
We then validated the accuracy of each mental representation of age with independent validators.
We then validated these SNPs in two independent populations comprising @number@ and @number@ healthy controls , respectively.
We thereby showed that the severity of the underlying FUS mutation determines the amount of cytoplasmic FUS accumulation and cellular vulnerability to exogenous stress.
We therefore aimed to investigate the association of ARS and / or ATS with hypertensive target organ damage ( TOD ) .
We therefore aimed to investigate whether inter-individual differences in relative telomere length ( RTL ) are associated with symptomatic PAD.
We therefore aimed to study the pathobiological determinants of aortic dilatation.
We therefore aimed to study the relation between selected cytokines and subsets of memory , and the impact of age in these relations.
We therefore analysed the effects of age on age markers and angiogenic properties of ADSC.
We therefore analyzed a series of single BM aspirates from @number@ healthy children who were evaluated as potential BM donors.
We therefore analyzed the effect of aging on liver regeneration and investigated mechanisms associate with poor regeneration of human liver.
We therefore believe the effects of these nominally significant variants on human longevity will be confirmed by future studies.
We therefore compared the role of facial motion in younger and older adults to assess whether motion can enhance perception when static cues are insufficient.
We , therefore , computed correction factor for education and provided percentile distribution of the adjusted scores to identify individuals with high levels of apathy.
We therefore conclude that accelerated aging exacerbates pathological tau phosphorylation , leading to changes in normal behaviour.
We therefore conclude that ALC1 plays a role in BER.
We therefore conclude that induction of differentiation , senescence , and autophagy in CML are a key in cell sensitization and DAC-induced apoptosis.
We therefore conclude that these antibodies have potential for further development as therapeutics to target APRIL-dependent survival in B-cell malignancies.
We , therefore , conclude this approach will facilitate multimodal imaging of muscle to provide new spatio-temporal information regarding electromechanical function of muscle.
We therefore conducted external quality monitoring for dried blood spot-based CRP measurement for the Indonesia Family Life Survey and the Longitudinal Aging Study in India.
We therefore crossed animals overexpressing A30P alpha-synuclein with synphilin-1 transgenic mice to analyze its impact on aggregation , protein clearance and phenotype progression.
We therefore demonstrate that the benefit of rest extends to ( spatial ) associative and temporal order memory in humans.
We therefore designed a retrospective study to address the question whether EC-IC bypass is a safe and efficient treatment in a patient cohort ≥70 years.
We therefore determined the effects of aging and caloric restriction on the expression of FXR and TGR5 in the kidney.
We therefore encourage further development of innovative approaches to the study of DHA metabolism and its role in human brain function.
We therefore evaluated a device for targeted UV therapy , which reduces irradiation of unaffected skin in MF patients.
We therefore evaluated fertility and ovarian function in tall women who did or did not receive such treatment in adolescence.
We therefore examined the association between vancomycin MIC and outcome considering various potential confounders.
We therefore examined the cross-sectional associations of estimated NEAP and PRAL with BMD in the Framingham Osteoporosis Study.
We therefore examined the influence of infiltrating macrophages on LF hypertrophy.
We therefore examined the relationship between intelligence quotient ( IQ ) and changes in cortical thickness and surface over time in @number@ healthy subjects.
We therefore examined the relationship of plasma LECT2 levels with various adiposity indices and cardiorespiratory fitness ( CRF ) in middle-aged and elderly Japanese men.
We therefore examined whether genetic susceptibility loci for pigmentation or melanoma was associated with PD risk in @number@ large independent datasets.
We therefore examined whether pioglitazone regulates vascular telomere biology.
We therefore examined whether this ratio could predict physical limitation by secondary analysis of the data in our previous study.
We therefore examine whether the work exit probability of one spouse affects that of the other.
We therefore have limited insight into how web-based interventions for family caregiver have been developed , implemented and evaluated across aging-related illness.
We therefore highlight @number@ functional consequence of the CR1 susceptibility allele and generalize the role of this locus to cognitive aging in the general population.
We therefore hypothesised that the emotional stress of bereavement would suppress immune function , specifically neutrophil bactericidal activity , in older adults.
We , therefore , hypothesized that low bioavailable estradiol and high SHBG would be associated with worse kyphosis.
We therefore hypothesized that the brain temperature would decline with age , and measured the temperatures of the lateral ventricles in healthy volunteers.
We therefore hypothesized that trabecular bone in childhood predicted both cortical and trabecular morphology in adulthood.
We therefore hypothesize that using cell phones contributes to the psychological well-being of older adults primarily through encouraging social relationships.
We therefore inactivated both Ltbp-4 isoforms in the mouse germline to model ARCL1C.
We therefore investigated associations between lower limb co-contraction and gait characteristics under normal and dual task conditions in healthy older adults ( @number@.4±5.9years ) .
We therefore investigated direction discrimination and speed discrimination when moving stimuli were either fixated or pursued.
We therefore investigated the alternative splicing of LMNA gene transcripts , and the post-translational processing of prelamin A , in s-IBM and control muscle samples.
We therefore investigated the expression of progerin and lamin A / C in normal human and mouse skeletal muscles of different ages.
We therefore investigated this issue with a large sample of @number@ young and @number@ older participants using alternative signal-detection theory ( SDT ) measures.
We therefore investigated whether butein , a tetrahydroxychalcone , could inhibit RANKL signaling and suppress osteoclastogenesis induced by RANKL or tumor cells.
We therefore investigated whether children's reports of individuals smelling good or bad differed as a function of age and pubertal status.
We therefore looked for potential genetic interactions with established PD mechanisms.
We therefore performed a comprehensive investigation for miRNAs from five different periods of bovine skeletal muscle development using next-generation small RNA sequencing.
We therefore performed a meta-analysis of available studies to determine whether there is an association between diet and risk of dementia.
We therefore performed an IPD meta-analysis on the association between standardized serum 25 ( OH ) D and mortality.
We therefore performed a stringent comparative investigation of impacts of these TDP-43 modifications on neural integrity in vivo.
We therefore performed a systematic review and meta-analysis of studies on the association between stiffness , cerebral small vessel disease and cognitive impairment.
We therefore performed this meta-analysis to derive a more precise estimation of any association.
We therefore propose a consistent and sustainable approach focusing on prevention.
We therefore proposed to study the stability of mitochondrial DNA under controlled experimental conditions , to understand its contribution to chronic complications of diabetes.
We therefore recommend assessing geriatric patients ' fall risk using a multi-factorial approach that incorporates patient characteristics , cognition , and gait dynamics.
We therefore recommend that REMS be used for outcome prediction and risk stratification of adult HPVG in the ED.
We therefore report here , for the first time , an age-related and stimulus-driven reduction of right hemispheric control of spatial attention in older adults.
We therefore set out to investigate the effects of peripheral surgery on the cognition and Alzheimer-related neuropathology in mice with different ages.
We therefore show that the acquisition and analysis protocols used are appropriate for multi-site experimental scenarios.
We therefore sought to describe the healthcare experiences and perceptions of retired U.S. citizens currently living in Mexico and Panama.
We therefore sought to determine the efficacy of a brow / forehead lift that involved disinsertion rather than muscle resection.
We , therefore , sought to investigate the relationship of activating JAK2 mutation and aberrant cytokine expression in MPN.
We therefore sought to review the relation between n-3 fatty acids and the risk of AF.
We therefore speculated that foot muscles may also diminish with age.
We therefore suggest incorporating the UHR test in analyses of balance in seniors.
We therefore suggest several key areas for future research.
We therefore suggest that iron overload may be a causative factor in the development of AD.
We therefore suggest that people with AS have significant differences in neuronal and lipid membrane integrity and maturation of the AHC.
We therefore suggest that these pathological scars should be classified on the basis of the factor that causes the endothelial dysfunction.
We therefore summarize the potential and the risks of cell-based therapies for the treatment of SUI.
We , therefore , undertook a systematic review and meta-analysis comparing Braden Scale predictive and concurrent validity within this context.
We think that beneficial effects of 17β-estradiol may be through ERα but it needs further studies.
We thus aimed to characterize an LMW-sized HA molecule that combines strong anti-aging abilities with efficient skin penetration but lacks potential proinflammatory effects.
We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD.
We thus analyzed the transcriptome of the temporal cortex of the primate Microcebus murinus using human oligonucleotide microarrays ( Affymetrix ) .
We thus argue that the precise nature of relations between aging , cognition , and brain function is underappreciated by using mean-based brain measures exclusively.
We thus demonstrate that decreased expression of SIRT1 drives accelerated senescence of PT-ECFCs , and acts as a critical determinant of the PT-ECFC angiogenic defect.
We thus explored the autonomic nervous system ( ANS ) profile of infected infants during the @number@ pandemic influenza disease.
We thus have a two-stage procedure , instead of a single fitness measure , which is a combination of R0 and r.
We thus identified a lifelong source of new beta cells at a specialized site within healthy islets.
We thus identify previously unreported signature events with O2∙- , PTP1B , and PTEN as promising targets for drug development to prevent IGF-1 resistance-related pathologies.
We thus propose that aging decreases the strength of suprahyoid muscles in healthy adults.
We thus propose that ALC1 is a unique BER factor that functions in a chromatin context , most likely as a chromatin-remodeling enzyme.
We thus propose that both training and rehabilitation regimens should consider gender-specific tendon responsiveness , at least in older persons.
We thus propose that the functions of human microglia evolve during both healthy and pathological aging.
We thus suggested that ADAMTS-5 is probably involved in the process of IVD degeneration , and that IL-1β-induced expression of ADAMTS-5 is mediated by NO.
We thus suggest that encouraging older people to keep on engaging in customary NLTPA is good for their health.
We took advantage of Drosophila genetics to investigate the role of macrophages and the pathway ( s ) that govern their response to dietary stress.
We took these measurements three times each , and the mean value obtained was used for statistical analysis.
We trained a classifier to distinguish between subjects who developed dementia and subjects who stayed cognitively healthy.
We trained classification algorithms to decode conscious perception from neural activity recorded during binocular rivalry using magnetoencephalography ( MEG ) .
We trained older adults aged 57-73 years in a WM training task that was reported to be effective in producing transfer in young adults.
We transduced C2C12 myoblasts with wnt-3a and found that CCN1 protein was increased in a time- and dose-dependent manner.
We translated self-reported medications to anatomical therapeutic chemical ( ATC ) codes ( at the second level ) .
We treated her with potassium chloride and started magnesium sulfate and lidocaine , and then added isoprenaline injection.
We treated these mice trans-nasally with CA twice weekly for @number@ months.
We tried SVM and RF classifiers for the original datasets and then for the modified ones.
We tried to determine whether orexin release or secondary changes in sleep via orexin modulation affect Aβ pathology.
We tried to identify difference in GFR evaluation between CKD-EPI and Gates method with renal scintigraphy and which variables are associated with these differences.
We try to explain in what way telomere shortening might be the cause of aging and longevity restriction.
We try to individually examine the contributions of the SNS in osteoporotic diseases from a different perspective.
We undertook a cross-sectional survey to identify clients ' support needs and explore their future concerns.
We undertook a grounded theory study to identify key psychosocial processes that underpin how and why people with ALS engage with health care services.
We undertook a prospectively recruited cross-sectional sample of HIV-positive and HIV-negative GBM ≥ @number@ years.
We undertook a study to determine the influence of these factors , and to explore pathologist's characteristics associated with the direction of diagnosis.
We undertook a systematic review and evaluation of published patient-level instruments for potential application in hospice and palliative care clinical quality measurement.
We undertook survival analyses using subdistribution and standard Cox hazards models and linear mixed models.
We undertook the current study to investigate if intraislet endogenous cannabinoids ( ECs ) regulate β-cell proliferation and if they influence insulin action.
We undertook the first histological comparative evaluation between genetically confirmed HGPS and the CVD of aging.
We undertook the present studies to search for potential factors that are regulated by caloric restriction and act as caloric restriction mimetics.
We undertook this study to determine whether audiometric HI is associated with mortality in older adults.
We undertook this study to evaluate the clinical value of EEG as a diagnostic and postoperative follow-up modality in pediatric moyamoya disease.
We undertook this study to examine whether CK2 downregulation modulates chondrocyte death.
We urge all stakeholders to give higher priority to adult immunisation in general and HZ in particular.
We use a diary-based method to overcome these limitations in a representative sample of U.S. residents.
We use a multinomial probit model to determine factors associated with type of care.
We use an age-and-stage structured population model to investigate the impact of sibling environmental inequality on the expected evolution of senescence.
We use a national health survey and administrative data in a multilevel model controlling for geographical , cultural and political differences between counties.
We use an auxiliary regression equation to impute TTD and employ multiple imputation techniques to obtain final parameter estimates and standard errors.
We use an inverse-probability weighted ( IPW ) estimator to derive a doubly robust augmented inverse-probability weighted ( AIPW ) estimator.
We use automatically localized feature descriptors which can identify disguised face patches and account for this information to achieve improved matching accuracy.
We used 3-D mapping methods developed at the Laboratory of Neuro Imaging ( LONI ) to compare regional variation in hippocampal width between dementia groups.
We used ( 5- ( 2- ( 4-hydroxyphenyl ) vinyl ) -1 , 3-benzenediol ) to study Sirt1 and Sirt3 modulation.
We used a case-cohort design consisting of a random subcohort of @number@ women not using hormone therapy and @number@ incident dementia cases.
We used a conceptual-analytical model to derive themes and used an inductive approach to organizing emerging codes as per a priori themes.
We used a cross-sectional , exploratory design to assess its internal consistency and construct validity.
We used a cross-sectional study of @number@ multi-ethnic community residents of New York aged @number@ years or older.
We used adjusted general linear mixed models to analyze functioning and HRQoL.
We used adolescent subjects in small age ranges.
We used Affymetrix microarray analysis and validated differentially expressed miRNAs using qRT-PCR.
We used a floor translation paradigm to induce a balance perturbation to thirteen elderly community-dwelling women.
We used age- and sex-adjusted linear mixed models.
We used a global cognitive z-score as a measure of cognition.
We used a graph theoretical approach to derive cognitive activation-related functional magnetic resonance imaging networks.
We used a light intensity of @number@ lux , which is considered the lower limit of light pollution in many countries.
We used a linear regression model to assess the effect of treatment on the PWV.
We used a longitudinal follow-up of @number@ waves during @number@ years.
We used a mammalian two-hybrid ( M2H ) system in order to study L1 ORF1p self-interaction in human and mouse cells.
We used a mendelian randomisation approach to test whether 25 ( OH ) D concentration is causally associated with blood pressure and hypertension risk.
We used a multinational ICH data registry to study the characteristics , course , and outcomes of supratentorial hematomas with volumes < 30 mL.
We used a Multiple Testing Procedure in R modified by our team to identify the significance of the candidate genes adjusting for a priori covariates.
We used an alternate age variable , functional biological age ( fBioAge ) , which was based on performance on functional body measures.
We used analysis of covariance to test for mean differences in CAC between GFR tertiles.
We used an archival website to obtain data on sodium , saturated fat , and trans fat content for these items from @number@ through @number@
We used an epidemiological population-attributable risk method to determine the costs that can be attributed to smoking and SHS exposure.
We used an established theoretical model of 3D arterial mechanics that assumes a hyperelastic , anisotropic , active-passive , and residually stressed wall.
We used an exploratory mixed-methods research design emphasizing the qualitative data ( in-depth , semi-structured interviews ) .
We used an in-scanner worry script that alternates blocks of worry induction and reappraisal.
We used an integrated knowledge translation approach to involve knowledge users in planning and administering the survey and in analyzing and interpreting the results.
We used ANOVA , with location as a repeated measure , to test for gender differences in cartilage thickness.
We used an overt gaze following task to explore age differences in overt gaze following whilst people searched for a target.
We used a @number@ deficit Frailty Index and combined @number@ cognitive deficits into a global cognitive impairment index.
We used a numerical model including an anatomically 3D geometrical model of the aortic root including the sinuses of Valsalva for their identification.
We used a parametric assessment of visual attention based on the Theory of Visual Attention.
We used ApoE knock-in mice of different ages and sex , and quantified newborn cells in the hippocampus by flow cytometry.
We used a process-dissociation procedure with word pairs to estimate familiarity and recollection.
We used a prospective nested-case control study ( n = @number@ cases and @number@ controls ) within the Physicians ' Health Study for current analyses.
We used a proven family design , comparing middle-aged offspring with and without a parental history of AD.
We used a ratio of relative telomere length derived by telomere-to-single-copy gene ratio ( T / S ratio ) .
We used a risk set sampling method to prospectively select @number@ incident CHD events and @number@ matched controls.
We used a same / different unfamiliar face discrimination task with @number@ young and @number@ older adults.
We used a sensitive gene-targeted deep sequencing approach to gain precision on the exact prevalence of driver mutations and the proportions of affected genes.
We used , as experimental approach in vivo , APP / PS1 mice , characterized by age-dependent brain amyloid-β ( Aβ ) accumulation.
We used a standardised telephone interview to re-assess patients at the 6-month follow-up.
We used a Stroop task that a priori dissociated stimulus and response conflict.
We used a structured questionnaire to collect demographic , clinical , social , and behavioral data.
We used a structured questionnaire with standardized tests to evaluate the relevant clinical and functional measures.
We use data from the Health and Retirement Study to construct two measures of health risks.
We use data from the National Social Life , Health , and Aging Project to identify older adults with undiagnosed or uncontrolled hypertension.
We used a targeted metabolomics approach to identify biomarkers for MI and evaluate their involvement in the pathogenesis of MI.
We used Beck Depression Inventory ( BDI ) for controlling depression.
We used bezafibrate as a model drug to assess the effect on a tissue-specific level in a murine model.
We used binomial logistic regression to determine predictors of discordance between the discharge medication list and the patient-reported list during postdischarge medication review.
We used blood oxygen level dependent functional magnetic resonance imaging ( BOLD fMRI ) to search for neural correlates of these behavioral phenomena.
We used both in vitro and in vivo models.
We used both online and manual search methods to gather the information and ' snowball ' further data.
We used brain amyloid-β load measured using Pittsburgh compound B positron emission tomography as a marker for amyloid pathology.
We used cancer registry data to simulate bias and DCO proportions resulting from various patterns of underreporting of deceased cases.
We used cohort and twin analyses of data with @number@ years of follow-up for stroke incidence to help address these gaps.
We used complex network measures , derived from a brain-wide graph , to provide a comprehensive overview of age-related changes in functional connectivity.
We used Cox proportional hazard models to estimate adjusted relative risks.
We used Cox proportional hazards models to estimate HRs and @percent@ CIs of DM.
We used Cox proportional hazards models to estimate multivariable-adjusted relative risks.
We used Cox proportional hazards regression to calculate the hazard ratios of each SNP with time to progression to PCSM after diagnosis.
We used Cox proportional hazards to estimate the hazard ratio of HF per SD of FFAs.
We used Cox regression to estimate multivariable-adjusted HRs for death according to nut consumption.
We used Cox regression to estimate multivariable adjusted relative risk of HF.
We used C-reactive protein ( CRP ) as a pathophysiologic marker of inflammation , previously associated with delirium.
We used data at baseline from @number@ participants aged @number@ years and older.
We used data from a 20- to 22-y follow-up study of @number@ Danish teenagers.
We used data from a longitudinal observational study in @number@ participants from the Study of Women's Health Across the Nation.
We used data from a subsample of the Longitudinal Aging Study Amsterdam , a population-based cohort of Dutch participants aged @number@ to @number@ years.
We used data from four waves ( 2006-2012 ) of the Korean Longitudinal Study of Aging ( KLoSA ) .
We used data from @number@ European cohorts from the ESCAPE study.
We used data from participants of the Rush Memory and Aging Project.
We used data from risk management and case costing databases to identify cost associated with a serious injury after an in-hospital fall.
We used data from the German Interdisciplinary Longitudinal Study of Adult Development ( ILSE study ; n = @number@ ) .
We used data from the Healthy Aging and Intellectual Disability study ( HA-ID ) to measure frailty in people with ID.
We used data from the National Central Cancer Registry , to describe and analyze the latest cancer statistics in China.
We used data from the @number@ Behavioral Risk Factor Surveillance System optional module on impact of cognitive impairment.
We used data from the @number@ cancer registries ( across @number@ countries ) that provided continuous incidence and good quality data from @number@ to @number@
We used data from these studies to obtain epidemiologic information about GBM.
We used data from the Toledo Study for Healthy Aging , a prospective Spanish cohort study.
We used data linkage to track the onset of dementia over @number@ years.
We used delayed embedding of the applied force to reconstruct its attractor.
We used diagnostic ultrasonography to produce images of subcutaneous tissue of the forehead , one of the areas where age-related wrinkles form.
We used early passaged and senescent none-immortalized fibroblasts as cellular aging models.
We used electroencephalography and evaluated resting-state intracranial functional connectivity between the left ARC and DLPFC in a sample of musicians with and without AP.
We used electron microscopy to identify and estimate the number of cells in human atrial myocardium ( appendages ) .
We used event-related fMRI to investigate the effect of aging on contextual binding and associated neural activity for words and objects.
We used factor analysis and latent class analysis to identify activity profiles and regression analyses to assess antecedents and outcomes associated with activity profiles.
We used familiar or unfamiliar faces in separate conditions to examine the role of familiarity.
We used findings from the Global Burden of Disease @number@ study to calculate the burden of diabetes in the EMR.
We used fMRI to test if severe WMH impact on functional brain network organization even before clinical dysfunction.
We used Framework Analysis to examine how well the HITAM accounted for the data.
We used functional magnetic resonance imaging of a hypothetical discounting task with monetary rewards delayed in the week to year range.
We used functional MRI to investigate the neural basis by which an interruption is more disruptive to working memory performance in older individuals.
We used Furtado's Constructivist Method of Evaluation , which provides practices of participative evaluation.
We used generalized estimating equation analyses to identify the baseline characteristics associated with the consumption of AChEIs and memantine over time.
We used generalized estimating equations regression analysis to examine the association between methylation and selected variables.
We used generalized estimating equations to estimate the association among variables.
We used Generalized Ranking and Averaging Independent Component Analysis by Reproducibility ( gRAICAR ) to investigate the lifespan trajectories of intrinsic functional networks.
We used grounded theory analysis.
We used high-resolution fMRI to examine activity profiles in the dentate gyrus and CA3 in young and older adults as stimulus similarity was incrementally varied.
We used high-sensitivity C-reactive protein ( hsCRP ) as an index of systemic inflammation , and fasting insulin and adiponectin as indexes of metabolic profile.
We used hospital discharge data from all publicly funded hospitals in Hong Kong between @number@ and @number@
We used information gain ( IG ) to identify the vocabulary features that were most informative to each of these two distinctions.
We used instrumental variable regression to correct for estimation bias and adjusted for potentially confounding factors.
We used inverse probability of censoring weights to reduce and quantify selection bias.
We used inverse probability of response weighting to adjust for potential selection bias due to loss to follow-up.
We used items from four existing scales and five new items to construct measures of high-quality and poor-quality care.
We used kinematic stabilometric parameters , recurrence quantification analysis ( RQA ) and the central tendency measure ( CTM ) .
We used latent class growth analysis to identify trajectory groups ' depressive symptoms.
We used life table methods to calculate mortality rates and life expectancies for this cohort by sex and 5-year age group.
We used linear and Poisson regression models to estimate associations of urinary paraben concentrations ( in tertiles ) with ovarian reserve measures.
We used linear logistic regression to examine SNP associations with SCA.
We used linear mixed-effects models including random subject intercepts and adjusted for several potential confounders.
We used linear mixed models to assess the association between MedDiet score and trajectory of cognitive decline.
We used linear mixed models to estimate associations , controlling for confounders.
We used linear regression adjusted for age , education , smoking , and alcohol intake to estimate the associations between lead biomarkers and tremor score.
We used linear regression models to assess period effects after adjustment for age , cognitive status , and neurofibrillary tangle ( NFT ) staging.
We used liquid chromatography-tandem mass spectrometry to assess metabolite levels at baseline and after 1-year follow-up.
We used logistic regression analyses to estimate odds ratios ( OR ) and @percent@ CI for the association between subgroups and motivations to eat healthily.
We used logistic regression models to assess the relationship between 25 ( OH ) levels and risk of recurrent stroke or functional outcome.
We used logistic regression model to assess the relationship between 25 ( OH ) D levels and risk recurrent stroke or mortality.
We used logistic regression to analyze the association between dementia status and use of osteoporosis drugs.
We used longitudinal analyses to estimate differences in cognitive decline across hormone groups.
We used longitudinal data from the Multi-Ethnic Study of Atherosclerosis ( 2000-2007 ) of @number@ adults who were aged 45-84 years at baseline.
We used longitudinal data to determine whether these homeostatic dynamics change across adolescence.
We used magnetofection ( MF ) to achieve high transfection efficiency into human mesenchymal stem cells ( MSCs ) .
We used mediation analyses to assess the extent to which other factors mediate the relationship between suicidal thoughts and age.
We used microcalorimetry to show that C. elegans swimming has a greater energy cost than crawling.
We used minimum norm estimate of source reconstruction to characterize the spatiotemporal dynamics of magnetic mismatch responses ( MMNm ) .
We used motion capture to assess cognitive and motor contributions to conflicting responses presented once , twice , or three times within single trials.
We used MR to investigate the inverse relationship between WHR and GMV.
We used multilevel logistic analysis adjusting for demographic and socioeconomic factors to predict smoking relapse in @number@
We used multiple assays to confirm that autophagic activity was downregulated in chondrocytes of aged articular cartilage.
We used multiple linear regression to examine the association between IR and performance-based physical function.
We used multiple linear regression to test whether olfaction-motor associations were independent of cognition and depressive symptoms.
We used multiple logistic regression to assess the association between colonoscopy conducted for specific indications within the past @number@ years and risk of CRC.
We used multiple logistic regression to identify factors associated with informant report of a prior dementia diagnosis among those with a study diagnosis of dementia.
We used multivariable Cox models to assess mortality risk with adjustment for disease severity using the VACS Index.
We used multivariable Cox models to estimate hazard ratios ( HRs ) and @percent@ confidence intervals ( CIs ) .
We used multivariable linear regression to examine cross-sectional relationships between food packaging or personal care product use and phthalate metabolites measured at age @number@ years.
We used multivariable logistic regression to examine the association between alcohol use and cognition.
We used multivariate analyses to examine changes on key outcome variables , controlling for major covariates.
We used multivariate linear regression models to identify the combined and independent protective factors for amyloid and AD-pattern neurodegeneration.
We used multivariate logistic regression to evaluate the association between hearing loss and the odds of having social isolation.
We used multivariate stepwise least likelihood regression of ' a priori ' variables to determine predictive factors.
We used national and Texas Medicare claims , Minimum Data Set ( MDS ) , and Texas Medicaid data from 2011-2013.
We used negative binomial and Cox regression to assess the association of 25-hydroxyvitamin D with ( centrally adjudicated ) exacerbations and mortality , respectively.
We used nodes from the automated anatomical labeling atlas to construct participant-specific correlation matrices of fMRI data obtained during 1-back tasks with interference and rest.
We used normal control and amnestic MCI subjects from the Alzheimer's Disease Neuroimaging Initiative @number@ ( ADNI-1 ) as normative reference and screening cohorts.
We used @number@ apparently healthy Tibetan male and female macaques to explore the effect of age and sex on physiologic parameters.
We used @number@ different design matrices with a full factorial design.
We used @number@ patients who had undergone orthopedic surgery between @date@ and @date@ .
We used @number@ Single Nucleotide Polymorphisms ( SNPs ) to estimate each individual genomic ancestry proportions.
We used pathway analysis to determine the relationship between changes in hormone levels , muscle mass , strength , and function.
We used pattern recognition and machine learning to detect and quantify these changes in a model-agnostic fashion.
We used Poisson regression to evaluate the association between obesity and disability incidence , adjusting for sociodemographic and clinical factors including BMI.
We used Poisson regression to model the relationship between these geriatric conditions and ADRs.
We used Poisson regression to obtain prevalence ratios ( PRs ) .
We used Poisson regression to study baseline ICTP and PIIINP relative to these outcomes.
We used propensity score matching to reduce the confounding bias between the groups.
We used propensity scoring analysis to examine the effect of testosterone replacement on the use of salvage hormone therapy and overall and prostate cancer-specific mortality.
We used prospective data from @number@ men and women aged ≥52 years in the English Longitudinal Study of Ageing from @number@ to @number@
We used pulegone and citral , components of Aloysia citrodora , and geraniol , citronellol , and linalool , components of Geranium sp. oil.
We used purposive sampling to recruit @number@ institutional managers who care for people with intellectual disabilities in Taiwan.
We used qualitative methods to collect data from @number@ older women living in Bibirchar Union , Sherpur District , Bangladesh.
We used qualitative research software NVivo10® to track the coding and manage the data.
We used quantitative and qualitative methods to assess the delirium superimposed on dementia experience among older patients.
We used recently described markers to characterize the origin and functional states of microglia / macrophages in acute , relapsing and progressive multiple sclerosis.
We used regression analyses to assess whether the SVR predicted MetS.
We used regression-based techniques to assess the effects of volume and market concentration on mortality over time , adjusting for case mix.
We used repeated measurement models to test multiplicative interaction between genetic variants and use of SSRIs on repeated CESD scores.
We used resting-state functional magnetic imaging and Aβ imaging in a cross-sectional sample of @number@ subjects across stages of AD and healthy older adults.
We used self-report data from six waves of the Australian Longitudinal Study on Women's Health over @number@ years.
We used : semi-structured questionnaire , scales ( Katz , Lawton and shortened version of Geriatric Depression Scale ) and Fragility Phenotype proposed by Fried.
We used senescence-accelerated SAMP8 mice as a model of sporadic AD and investigated the relationship between Aβ and oxidative stress.
We used serial measurements to assess the effect of retirement on sleep disturbances.
We used simple signal processing for the accelerometry signals to minimise the effects of unwanted variability that could affect the results.
We used Southern blotting techniques and densitometry to estimate the repeat size of the most abundant expansion species.
We used Spearman correlation coefficients to examine the correlation between cognitive function and sociodemographic variables.
We used Spearman's rank correlation to look for the associations of gene expression with paternal age at conception.
We used spectrophotometric and fluorometric methods.
We used statistical parametric mapping ( SPM8 ) to investigate sex differences , and aging effects.
We used statistical weights to adjust for population differences.
We used structural equation modeling to form seven latent white matter factors ( FA and MD ) and one latent PS factor.
We used survival analysis to examine the relationship between income inequality and risk for mortality among older individuals living in @number@ districts of São Paulo.
We used survival methods to assess the association between older age and all-cause mortality , as well as time to treatment modification.
We used task-free fMRI with a focus on the medical temporal lobe , together with Aβ PET imaging , in cognitively normal elderly human participants.
We used template analysis , iteratively cycling between data collection and analysis , using a constant comparative process.
We used the Cochran-Armitage test for associations between the degree of BPH and clinical variables and proportional odds logistic regression models in multivariable analysis.
We used the commercial geodemographics dataset , Mosaic Japan to categorize and classify each neighborhood.
We used the Frisby test at distances ranging from 30-80 cm and FD2 at @number@ m.
We used the Information and Digit Span subtests of the Wechsler Adult Intelligent Scale-Revised as measures of semantic memory and short-term memory , respectively.
We used the information systems database of Datasus and IBGE.
We used the manometric method with continuous perfusion.
We used the mediation model to explore the potential mediating effect of CAS and PAD on the associations of aggregated VRFs with functional dependence.
We used the Minimum Data Set @number@ records of @number@ residents in a nursing home from @date@ to @date@ .
We used the multivariable Cox regression model to identify the updated weighting for components in the original PF model.
We used the Outdoor Falls Questionnaire ( OFQ ) , a valid and reliable tool as the survey instrument.
We used the Pooled Cohort equations to calculate the incidence of high ( ≥7.5% ) 10-year predicted ASCVD risk at visit @number@
We used the pragmatic utility method to analyze the concept of patient decision making in the context of older individuals with cancer.
We used the reflective adaptive process as a relationship building framework that recognizes primary care practices as complex adaptive systems.
We used the regression models and latent class analysis to analyze the correlatives of successful aging and to classify the elderly individuals by perception types.
We used these data to calculate sensitivities , specificities , and their @percent@ confidence intervals.
We used the short version of the Utrecht Coping List , the Multidimensional Health Locus of Control scale , and the 15-item Geriatric Depression Scale.
We used the small interfering RNA ( siRNA ) directed against Beclin-1 to infect the osteosarcoma cell line with relatively high Belcin-1 expression.
We used the Sullivan method for calculations of HLE and a decomposition into mortality and disability effects was made.
We used the total degree of WML ( range : 0-30 ) by adding the region-specific scores of both hemispheres.
We used this factor score to predict white matter lesion volumes acquired via fluid attenuated inversion recovery ( FLAIR ) magnetic resonance imaging.
We used this system to assess anti-aging compounds.
We used time-dependent Cox regression to estimate hazard ratios of incident any dementia and Alzheimer's disease.
We used time sampling to perform a structured observation study.
We used TPL2 knockout ( KO ) mice to investigate the role of TPL2 in mediating obesity-associated inflammation and insulin resistance.
We used two independent approaches to test whether decreasing ataxin-2 levels could mitigate disease in a mouse model of TDP-43 proteinopathy.
We used two kinds of tests : speech in noise and dichotic alternated dissyllables ( SSW ) .
We used voxel-based morphometry and tract-based spatial statistics for voxel-wise analyses of gray matter volume and diffusion tensor imaging measures.
We used voxel-based morphometry to analyse grey matter volume between groups using a three-group ANCOVA , followed by six pairwise post-hoc group comparisons.
We used whole-exome sequencing to identify variants other than APOE associated with the rate of hippocampal atrophy in amnestic mild cognitive impairment.
We used whole-genome sequencing data from @number@ individuals through the UK10K program and deep-imputation data from @number@ individuals genotyped genome-wide.
We used wild-type ( Wt ) mice and MIPKO mice to elucidate the roles of MIP in muscle function during aging.
We use entropy to characterize intrinsic ageing properties of the human brain.
We use hearing aids as an instrument for functional hearing.
We use longitudinal cross-national data collected by SHARE I and SHARE IV and focus on the respondents who were working at baseline.
We use multiple regression to examine maternal support and self-reported health as moderators of maternal problems on offspring depressive symptoms.
We use multivariate analysis to model neural activation separately for FR and responses ( R ) at each trial phase.
We use nationally representative survey data to examine whether racial / ethnic disparities exist in reported Part D satisfaction and plan evaluations.
We use nonparametric methods to determine the relationship between BMI and mortality.
We use ordinal logistic regression to identify independent factors associated TSLV.
We use quantitative and qualitative data to explore the psychological impact of weight change among American adults.
We use regression methods for purposes of inferring program impacts.
We use RNA-Seq of synchronized populations of in vitro-derived platelet-like particles to show that mRNA decay strongly shapes the nascent platelet transcriptome.
We use the technique to demonstrate altered levels of presynaptic proteins in Alzheimer disease patients and prion-infected mice.
We use the term Pleiotropy Index to denote the number of traits with low association P-values at a particular genomic region.
We use this approach primarily for epidemiological studies that examine leukocyte telomere length.
We use this method to obtain the phase-coupling functions describing cardiorespiratory interactions and the phase response curve of @number@ healthy humans.
We use unique representative data collected in the spring of @number@ through in-home interviews.
We usually think of an individual's cells as sharing the same genome.
We utilized a cross-sectional baseline data from the Hawai'i Aging with HIV-Cardiovascular Study cohort.
We utilized array-generated single-nucleotide polymorphism data that were well correlated with independent measures of heteroplasmy.
We utilized a standardized regression-based ( SRB ) approach to determine statistically significant changes in test scores over time.
We utilized a two-stage SNP association study to detect variants associated with breast cancer survival in a TP53-dependent manner.
We utilized measures of stressful life events ( SLE ) and hassles from @number@ to @number@ and men were followed for mortality until @number@
We utilized Wt1 + / - mice as a model to mechanistically pinpoint the consequences of reduced Wt1 levels for female fertility.
We validate and quantify the expression levels of these novel isoforms in HGPS and wild type fibroblasts.
We validated a newly developed classification system for ischemia.
We validated DI-PLA by demonstrating its ability to detect DSBs induced by various genotoxic insults in cultured cells and tissues.
We validated each method against Texas @number@ Medicare-Medicaid linked data for those with dual eligibility.
We validated our approach using model fit indices and comparing baseline mobility-related factors between trajectories.
We validated our method via computer simulation together with a model estimated from @number@ normosmics.
We validated our miRNA results by semiquantitative real-time polymerase chain reaction ( PCR ) in independent prefrontal cortex.
We validated our model using a separate data set of @number@ participants from the National Alzheimer's Coordinating Center's Uniform Data Set.
We validated seven chronic disease ascertainment algorithms for use in the Canadian Longitudinal Study on Aging.
We validated the presence of APH-1A promoter polymorphism -980C / G in other two Chinese cohort sets ( @number@ AD and @number@ controls ) .
We validated the stated 99th percentile ( @number@ ng / l ) using a large population of healthy adults representative of the Northern California population.
We validated this equation in the KLoSHA.
We validated tissue segmentation against reference semimanual delineations.
We validate this approach by in situ mapping of telomere elongation patterns within individual nuclei and across a population of cells.
We verified if vascular risk factors or depressive symptoms could modify this predictive role.
We verified our findings by comparison to a published dataset.
We verified the reproducibility of PAR and agreement with spectral analysis of heart rate variability in group1 participants.
We videotaped interactions from six caregiver-infant dyads playing with toys when infants were @number@ @number@ @number@ @number@ and @number@ months old.
We visualized Apo D immunohistochemically and then performed a quantification of the chromogen signal strength.
We wanted to determine the effects of a lycopene-restricted diet on oxidative stress parameters and bone turnover markers in postmenopausal women.
We wanted to determine whether neuropsychological tests could accurately predict incident dementia within @number@ and five years of diagnosis in a community-based sample.
We wanted to identify variables of importance for reaching @number@ years old and determine how the predictive ability of these variables might change over time.
We wanted to investigate the possible role of KCs and liver DCs in the development of liver injury in patients with liver failure.
We were able to capture changes that occurred over time for older adult participants.
We were able to demonstrate this in this pilot study by applying only a comparatively simple and economically viable method.
We were able to generate models that explain the relationship between physical activity , diet , and these health measurement parameters.
We were able to identify @number@ novel CpG sites with significant association of methylation with age.
We were able to show for the first time that in plasma miRNA profiles change within days after colorectal cancer surgery.
We were able to show that mitophagy is impaired in senescent cells resulting in an increased mitochondrial mass and superoxide formation.
We were concerned that this narrow approach might have skewed our understanding of CMV-specific immunity at older ages.
We were particularly interested in determining whether the association between psychosocial factors and aortic pulse wave velocity differed for older blacks compared with whites.
We were successful in this endeavor , using a comprehensive stepwise approach , leading to a wealth of findings.
We were the first in the world to succeed in identifying small-molecule compounds that serve as seed compounds for candidate AdipoR-activating drugs.
We were unable to detect significant differences between groups of practitioners and non-practitioners of exercise for this study.
We were unable to identify studies depicting a negative impact of drugs or ARV regimens on limb fat loss.
We will all benefit if we design and implement a better system of care for persons with dementia.
We will also compare changes in engagement in physical activity , HRQOL , physical function , and self-efficacy.
We will also explain measures the Journal of Neurochemistry have implemented to overcome these issues and weaknesses in preclinical research.
We will also outline the methods currently employed to direct their differentiation into populations of tissue-specific , functional cells.
We will also overview the efficiency of physical exercise and nutrition on muscle subcharacteristics.
We will also share our perspective on the potential of dish models of neurodegenerative diseases for studying pathogenic cascades and therapeutic drug discovery.
We will also speculate on additional mechanisms that might promote eye repair based on data from other tissue injury models.
We will analyze the impulses that led to the emergence of the field and the forces that have inhibited or delayed its development.
We will compare age-related changes to those associated with reproductive aging and menopause and the effects of estrogen therapy on selected health outcomes.
We will concentrate on aspects of home and health captured by state-of-the-art methodology from gerontology as well as PD-research , health science and rehabilitation.
We will conclude by describing molecular machinery of axonal transport and genes that may contribute to inter-individual variations in axonal diameter and axonal transport.
We will describe the physiological functions of macroautophagy and CMA in neuronal cells.
We will detail this data platform in terms of its architecture , its data integration strategy , and its data services.
We will discuss how a good palliative care can be an alternative to these ethical dilemmas.
We will discuss the availability and mechanism of action for several diverse physical activity pharmacomimetics.
We will discuss the molecular basis of age-related resistance to apoptosis and emphasize that increased resistance could enhance the aging process.
We will discuss the possible source of these bridges and the role that FA proteins and BLM might play in their removal.
We will discuss the role of quality assurance pathways in cell-autonomous and systemic responses to genome instability.
We will evaluate the effect of delirium on cognitive function over time along with the predictive value of clinical parameters.
We will explore the benefits of such a system in avoiding the development and progression of malignancies , and in avoiding tissue exhaustion and failure.
We will face mainly the biological , cognitive and psychological dimensions of ageing.
We will focus in this review on the possible link between neurodegeneration and infections particularly Chlamydophila pneumoniae , Borrelia burgdorferi , Mycoplasma etc.
We will focus on recent studies investigating mTOR and Alzheimer's disease , Parkinson's disease , and polyglutamine expansion syndromes such as Huntington's disease.
We will focus on the effects of estrogens on sleep and emphasize the need for primate models to better understand these complex interactions.
We will follow the STROBE guidelines for reporting the results of observational studies.
We will highlight how these findings are opening avenues for early detection and new interventions to reduce exploitation risk.
We will illustrate our theoretical outline by presenting first results from the IRMA-study comparing Luxembourgish and Portuguese immigrant families living in Luxembourg.
We will present recent evidence indicating that Sirt1 may protect against Alzheimer's disease by interfering with the generation of beta-amyloid peptides.
We will review the AMPK pathways involved in the inhibition of NF-κB signaling and suppression of inflammation.
We will review the astroglial changes occurring during aging and emphasize that senescent astrocytes can have an important role in age-related neuroinflammation and neuronal degeneration.
We will review the mechanisms of increased radioprotection in hibernation , and discuss possible impact on human space exploration.
We will show that such an approach is feasible and that the results coincide well with the findings from neuroimaging studies.
We will specifically focus on how alterations in this regulation may be implicated in disease and particularly in diseases of stem cell aging.
We will specifically focus on three aspects of BBB dysfunction : disruption , perturbation of transporters , and secretion of neurotoxic substances by the BBB.
We will summarize available data relating to EE as a potential therapeutic strategy that slows down or counteracts age-related cognitive and behavioural changes.
We will summarize current knowledge on FTO biology combining human genetic epidemiology , molecular models and findings from animal studies.
We will summarize these recent results and offer explanations , whenever possible , and hypotheses when not.
We will summarize the state-of-the-art AAL technologies , tools , and techniques , and we will look at current and future challenges.
We will then demonstrate how these variables can be used to predict potential targets for experimental analysis.
We wished to measure brain activity in children using a novel whole-head MEG system custom sized to fit the heads of pre-school-aged children.
We wonder whether the specific field of knowledge about time is altered during AD.
We worked with @number@ MRIs from the database of the Alzheimer's Disease Neuroimaging Initiative ( ADNI @number@ @number@.5T ) .
We would also like to explain changes in anti-thrombotic therapy aiming at the primary prevention of atherosclerosis and its usefulness.
We would argue that these pathways are closely interrelated and combine to lead to anemia in aging individuals.
We would expect this developmental program to be regulated by a set of interacting protein networks that connect environmental and molecular signals.
We would like to draw attention to the measuring of alkaline phosphatase and the differential diagnosis for low serum activity.
We would like to spend more money on all sorts of nice things and devote more time to our cherished activities.
WfT declined significantly over time as people aged and the declines were more precipitous for older persons.
WG definitions focus on the principal components of the WGs and their proportions , whereas WG-food definitions describe the quantity of WGs present in food.
What advances does it highlight ?
What also remains to be determined is whether receptor for advanced glycation end-products ( RAGE ) ligands could affect sRAGE assessment by epitope masking.
What alterations in sleep quantity and quality occur as we age , and are there functional consequences ?
WHAT ARE THE IMPLICATIONS FOR PRACTITIONERS ?
What are the neural correlates of such impaired cognition ?
What are the underlying neural mechanisms that explain age-related sleep disruption ?
What can be expected in normal aging , and where does normal aging stop and pathological neurodegeneration begin ?
What can we expect in the future ?
What choice do I have ? \ " bearing the brunt ; \ "I'm an old woman changing diapers , \ " full-time parents.
What determines the transition from asymptomatic diverticulosis to symptomatic diverticular disease is unclear but neuromuscular changes following acute diverticulitis may be responsible in some cases.
What does this mean for the provision of informal care in the next decennia ?
WHAT DOES THIS PAPER ADD ?
What does this study add ?
What does this study add ?
Whatever the child-care-centre group , the age subgroup or the gender considered similar results are found.
What explains such childlike responses ?
What explains the other two-thirds ?
What follows is a review of issues associated with COPD and its treatment in the elderly patient.
What happens upon temporary or ultimate homeostasis breakdown ?
What if anything can we learn about more general processes of aging from reproductive aging ?
What if Koschei's anti-aging formula included rapamycin ?
What is good for the heart is generally good for the brain as well.
What is it like to be a happy elderly person who is moving toward death ?
WHAT IS KNOWN ABOUT THE TOPIC ?
WHAT IS KNOWN ALREADY : AMH and AFC have proved to be reliable predictors of ovarian ageing.
WHAT IS KNOWN ALREADY : Both aged men and young asthenozoospermia patients have poor sperm quality.
WHAT IS KNOWN ALREADY : POI is a result of pathological reproductive aging and encompasses occult , biochemical and overt stages.
WHAT IS KNOWN ALREADY : Semen quality is an established predictor of men's somatic health.
WHAT IS KNOWN ALREADY : Sex steroid hormones play important roles in the development of cardiovascular diseases ( CVD ) .
WHAT IS KNOWN ALREADY : The association between type @number@ diabetes and early menopause has been examined previously with inconsistent results.
WHAT IS KNOWN ALREADY : The endogenous AGEs are produced in the body by chemical reactions.
WHAT IS KNOWN AND OBJECTIVE : Despite intriguing initial and associational studies , there remains little research on opiate-related arterial dysfunction and no longitudinal studies.
WHAT IS KNOWN AND OBJECTIVE : There are few studies examining both drug-drug and drug-disease interactions in older adults.
WHAT IS KNOWN : Left atrial and ventricular alterations have been reported in obese adults , and they represent predisposing factors for cardiovascular disease.
What is less understood is the extent to which this association is dependent on prestroke cognitive functioning.
What is more , these biological effects can be seen as early as middle age.
What is needed is an evidenced-based serum magnesium reference interval that reflects optimal health and the current food environment and population.
WHAT IS NEW AND CONCLUSION : The HPV vaccines appear safe and effective.
WHAT IS NEW : Obese normotensive children showed a moderately increased atrial size , subtle alterations in left cardiac diastolic function , and ventricular mass.
What is the central question of this study ?
What is the central question of this study ?
What is the central question of this study ?
What is the central question of this study ?
What is the excess risk of osteoporosis in a 70-year-old man receiving endocrine therapy for prostate cancer ?
What is the explanation for this phenomenon ?
What is the link between insulin resistance ( IR ) , cellular aging and diseases ?
What is the main finding and its importance ?
What is the main finding and its importance ?
What is the main finding and its importance ?
What is the main finding and its importance ?
What is the risk of coronary artery disease after mantle irradiation for Hodgkin lymphoma ?
What is the significance of the menopause ?
What is the topic of this review ?
What is unclear however , is whether epithelial-mesenchymal transition ( EMT ) contributes to this age-related renal fibrosis.
What leads a person to commit this final , desperate act , and how might we predict , intervene , and prevent suicide ?
What legacies do they think it is important to leave for the next generation ?
What parameters influence them ?
What quantity of change is significant ?
What remains unknown is which type of activity might be most useful , and whether everyone benefits similarly from the same interventions.
What role does language play in the way they experience and make sense of their lives ?
What should individuals older than @number@ years know to mitigate the effects of aging both physically and professionally ?
What's more , the antioxidant capacities of CS-SeNPs were more evident in viscera than in skin.
What the authors present here is a technique of analysis rather than detailed results.
What , then , is the impact in a pathological context , such as oncology ?
Wheals , which resolved without intervention or long-term sequelae , were reported for @number@ patients.
When accounting for the demographic projections for @number@ the number of incident fractures was estimated at @number@ in @number@ representing an increase of @number@ fractures.
When activated , T cells undergo a metabolic switch to accommodate their changing needs at every stage of the immune response.
When a curative treatment is not possible , absorbent pads or a penile sheath in males improve patient comfort.
When acute problems occur , catheterization is required and a review of precipitating factors may identify medications contributing to the condition.
When added to a ' fresh ' orange flavor model system , 50-60% of the isolates were reported to cause a sensory change.
When adherence is high , positive effects on strength , performance and well-being can be expected.
When adjusted at means of covariates , persistent AF and age > 75 years remained highly significant ( P < @number@ ) .
When adjusted for age-11 cognitive ability , diabetes status was not associated with cognitive ability at age @number@
When adjusted for gender and diseases , the magnitude of this effect is unclear.
When adjusted for health , none of these factors related to the survey design were significant.
When adjusting for depression , these associations were no longer significant.
When adult remains are in question , this process becomes even more complex.
When a family caregiver's mental health was \ "poor , \ " the patient recovering after hip-fracture surgery was more likely to recover poorly.
When affect variability was made comparable across age groups , affect complexity also became comparable across age groups.
When a further @number@ foodservice items were retained due to practical importance , the analysis explained around @percent@ of the variance in foodservice satisfaction.
When age-11 IQ and adult social class were controlled , only physical activity remained significantly associated with general cognitive ability and processing speed.
When age interactions are suspected , breast cancer studies should be stratified by early versus late age of onset or analyzed age specifically.
When age was controlled , lower cognitive speed and flexibility was independently associated with WMH in the superior corona radiata.
When aging sealants on aprismatic enamel with different procedures , significantly lower SBS was found for @number@ thermocycles.
When a large plaque ( > 4mm ) was identified , detailed 3-dimensional ( D ) observations were performed using a 3D zoom mode.
When all mediators were taken into account simultaneously , 44-76% of the association between the intervention and the outcomes was explained.
When allocation decisions were allowed to freely evolve , both menopause and extensive post-reproductive life-span emerged under some ecological conditions.
When all the variables were added in the multiple model , the dementia effect completely disappeared.
When analysed as a continuous variable , higher FI was linked with lower SOS , BUA and QUI ( P < @number@ ) .
When analysing age-period-cohort effects , it is important to be aware of these health and design issues as they may lead to incorrect conclusions.
When analysis was restricted to hospital admissions after the first @number@ years of follow-up , the difference was @number@ bed-days per person per year.
When analyzed separately , only retinal lutein ( plus meso-zeaxanthin ) , not zeaxanthin , was significantly related to lutein in the occipital cortex.
When an upright posture was assumed.
When applied as an eye drop , L-carnosine cannot penetrate the eye.
When applied for @number@ s , @percent@ BAC inhibited total MMP activity by @percent@ , and @percent@ BAC inhibited total MMP activity by @percent@.
When appropriate , intervention effects were presented as rate ratios with @percent@ confidence intervals.
When appropriate , older women should be encouraged to consider PMBR.
When a rare genetic disorder is present , profiles can be matched when one or more pathogenic variants are identified.
When articular cartilage deteriorates , whether due to injury , wear and tear or normal aging , osteoarthritis and resultant pain can ensue.
When asked to recall the route following the walk , only half of participants gave completely correct directions.
When assayed at these concentrations , trichlorfon and mipafox reduced neurite outgrowth and increased intracellular calcium , events implicated in the development of OPIDN.
When assessed by Mini Nutritional Assessment , @percent@ was classified as malnourished or at risk of malnutrition , with no difference between groups.
When assessed within each age group these correlations were only significant at age 16-18 , except for PINP which was also significant over age @number@
When associated with other macular disease , VMT is classified as concurrent.
When a subgroup analysis was conducted by ethnicity , the A-670G polymorphism was also not related with AD in Asian and Caucasian population.
When a subgroup analysis was conducted by ethnicity , the A-670G polymorphism was also not relevant to AD.
When a surgical treatment is chosen , the procedure should be as minimal invasive as possible.
When a target was reached , the participant had to return to the central target in order to start a new trial.
When autobiographical memories are elicited with word cues , personal events from middle childhood to early adulthood are overrepresented compared to events from other periods.
When available , radiographs and CT scans for these children were also reviewed.
When a wider spectrum of health dimensions is considered these rates are better approximated by quadratic law.
When Beclin-1 expression was inhibited , the expression of PI3Kp85α , p-AKT , and MMP-9 was downregulated in HOS cells.
When BMI was considered , significance was maintained only in the Tinetti Mobility Test.
When both age groups walked with the same speed and step length , no age difference in required COF was found.
When broken down by risk status , the Low and Medium Risk Groups were statistically superior to the High Risk Group on cognitive measures.
When CD14 ( + ) monocytes were depleted from the HUCB MNC , activity and motor asymmetry were similar to the MCAO only treated animals.
When CDR = @number@ ( severe ) , @percent@ of the FTD and @percent@ of the AD subjects had abnormal Luria tests.
When children go missing for many years , investigators commission age-progressed images from forensic artists to depict an updated appearance.
When chronically present , senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging.
When clinically indicated , patch and photopatch testing should be performed to common UV filters.
When combined with increased PVCs , HRV improved the predictive power of the Health ABC score.
When combined with Pten ( phosphatase and tensin homologue ) loss , double-mutant mice were prone to invasive cancer development.
When combined with the AGE-crosslink breaker Alagebrium , exercise training reverses cardiovascular aging in experimental animals.
When combined with the natural thinning of the brow with aging , the result can be a sparse or even absent eyebrow hair over time.
When combining both VITA- and Milano study rs3810950 was significantly associated with AD ( p ( combined ) = @number@ power = @percent@ ) .
When compared to healthy individuals , elderly fallers demonstrated a greater ankle plantarflexor moment at seat-off.
When compared to sensitive clones , resistant clones exhibited slower tumor development in animals.
When compared with healthy seniors , patients with Alzheimer's disease had significantly elevated ( p < @number@ ) serum level of endoglin.
When compared with normal weights , the OR ( 95%CI ) of people with low weight was @number@ ( @number@ - @number@ ) .
When compared with other treatments , it showed similar results but was preferred due to minimal side effects and shorter downtime.
When comparing distribution curves of the young , we see a significant difference in the elderly subjects ' phalanges plantar pressure record time series.
When comparing motor performance of the dominant and nondominant hands , older adults tend to be less asymmetric compared to young adults.
When comparing the patients who improved the most to all the other patients , they had lower preinjection region-specific scores.
When comparing the results for complex sounds to thresholds obtained for pure-tones in a previous study by Heinrich and Schneider [ ( @number@ ) .
When comparing these results to qualitative results on post-implementation acceptance , our analysis showed that some factors are persistent while new factors also emerge.
When comparing young versus old adults , a robust maturational-aging effect was observed in overall error rates and in the distribution of errors across affects.
When considered together , the Matsuda index and fasting glucose were the strongest predictors of lower midthigh muscle cross-sectional area after covariate adjustment.
When considering case scenarios , management strategy shifted significantly from extirpation to ablation or surveillance as patient age and comorbidity profile increased.
When considering its role in the obesity epidemic , it is advisable to consider its various dimensions together to best inform prevention and treatment efforts.
When considering such age-related changes , it is difficult to separate pathological change from physiological change , and cause from consequence.
When considering the potential role of diet , two factors need to be considered.
When constrained to the same @number@ different terms , pharmacists identified @number@ DRPs.
When controlling for additional measures of cognitive ability , we found that although age was no longer associated with performance , numeracy remained significant.
When controlling for age-related overall brain structural changes , only minor attenuations of the tract-cognition associations were found , and these were primarily with g.
When controlling for age , relationship status , and health remained significant predictors of select sexual behaviors.
When controlling for age , there was no difference found between the early and late postmenopause stage mean scores.
When controlling for baseline cognitive abilities , the effect remained significant for self- and informant-reported functional limitations.
When controlling for contraction type , the additional modifiers played minor roles.
When conversing on a cell phone , older adults were less likely to complete their crossing compared with when listening to music or undistracted.
When coresidence occurred , the analysis explored how individual children's characteristics were associated with their coresidence with the mother.
When coupled with larger sample sizes , cerebrovascular neuropathologic phenotypes will likely be powerful tools for the genetic dissection of susceptibility for ischemic stroke.
When current therapies fail to cure or improve SUI , application of regeneration-competent cells may be an alternative therapeutic option.
When data are oversampled , SE may give misleading results.
When data from all time points were considered , @percent@ of those who reported exhaustion were exhaustion free the following year.
When defective or absent , Werner syndrome protein ( WRN ) causes a genetic premature aging disorder called Werner syndrome.
When demographics and prior memory test performance were used to calculate pretest probability , consideration of the telephone measures significantly improved diagnostic validity.
When designing health applications is necessary to take into account the preferences of those who are targeted.
When detected on neuropsychological tests , it may still be difficult to distinguish normal from pathological changes.
When diastolic blood pressure was accounted for , the relationship between hydration status and cognitive skills was attenuated.
When distributed by decades of life the steepest AARIs occurred at the 20-29 decade , while the flattest at the 60-69 decade.
When do infants start to understand that they can grasp an object by its handle when the interesting part is out of reach ?
When dual task demands were moderate , older adults ' speech rate declined but their fluency , grammatical complexity , and content were unaffected.
When encountering disease related stimuli microglia adopt an activated phenotype that typically includes a rounded morphology.
When engaged in an attention-demanding task , people are surprisingly vulnerable to inattentional blindness the failure to notice an unexpected event.
When estimating risk in secondary prevention in very old age , use of NT-proBNP should be considered.
When etoposide was removed , such cells resumed proliferation upon addition of serum.
When evaluated between controls , CD18 for the noninjured elderly ( NIE ) was also significantly higher than the noninjured young ( NIY ) .
When evaluating growth-related changes , condylion should be preferred as condylar reference , and symphyseal landmarks should be favoured over gonion.
When evaluating the photographs , @number@ plastic surgeons wrote down the perceived age of each patient.
Whenever possible , a conservative approach directing bias against PHF-W rather than its comparators was applied in the base case analysis.
Whenever treatment is indicated , the endocrine literature has recommend testosterone replacement.
When examined at the same age , later born cohorts are often cognitively and physically fitter than earlier born cohorts.
When examined independently , discordant PiB and discordant FDG were both associated with diagnostic change ( unadjusted p < @number@ ) .
When examining more specifically each of the seven age-friendly domains , all but housing was positively related to life satisfaction.
When excessively activated , microglial response can also have detrimental effects via the exacerbation of inflammatory processes and release of neurotoxic substances.
When exercise and amino acid-based nutrition were combined , only @number@ of the @number@ study arms provided sufficient evidence of age-related muscle anabolic resistance.
When experience impacts these same neural circuits , it interacts with degenerative and regenerative cascades to shape neural reorganization and functional outcome.
When expressed alone , mutations in human PS1 do not induce any detectable lesions , although they do increase Abeta peptides.
When extended with a small quadratic element , the Gompertz model is used to fit the remaining @number@ cases.
When facets were residualized for their domain scores , a majority had significant ( p < @number@ ) residual age-correlations.
When facing a conflict , older adults are less able to activate goal-relevant information and inhibit irrelevant information.
When facing the challenges of pelvic floor dysfunction , surgical procedures are the most common treatment modality.
When FH + groups were split , only FHm was associated with longitudinal measures of brain change.
When FoxO3a expression was inhibited , the expression of melanogenic genes and melanin levels increased.
When FSIQ was used in the regression model rather than IQ decline , executive functioning was no longer uniquely associated with daily living skills.
When further stratifying the sample into two age groups , the associations were reliable in the old-old ( ≥ @number@ years ) only.
When gait speed and hand-grip strength were combined as a dual measure , the positive predictive value increased to @percent@.
When Gan mice were crossed with the Vash2-deficient ( Vash2 The thymus is essential for T cell development and maturation.
When grouping by gender , such differences were found only in men.
When HaCaT keratinocytes were exposed to Rb3 prior to UV-B irradiation , Rb3 exhibited suppressive activities on UV-B-induced ROS , proMMP-2 , and proMMP-9 enhancements.
When HRT had been used for longer than @number@ years , median CAC level was less than @percent@ of that observed in never users.
When human cancer cells were treated with DNA damaging agent , adriamycin ( @number@ μg / ml ) , p21 was induced following p53 induction.
When IIEF scores were compared between the two groups , group II showed better symptom scores than group I at weeks @number@ and @number@
When inactive Atg3 and Atg7 are protected from oxidation due to stable covalent interaction with their substrate LC3.
When incorporating TMS paradigms in research studies , methodologic considerations include technical aspects of TMS , cohort selection and confounding factors , and subject safety.
When indicated , menopausal hormone therapy should be considered to manage bothersome symptoms.
When individual hearing thresholds were considered as an additional independent variable , hearing loss was the only significant contributor to the benefit models.
When infants first begin to sit independently , they are highly unstable and unable to maintain upright sitting posture for more than a few seconds.
When informal caregivers care for a confidant , the emotional bond may reduce the depressive symptoms.
When informed their patients had diarrhea , @percent@ advised them to stop the antibiotic.
When injected into aged animals , tPA , although toxic to the gray matter , rescues white matter from ischemia independently of its proteolytic activity.
When intakes were compared using nutrient density , all significances were abolished across all nutrients of interest.
When intensity increased , the elderly also plantarflexed their ankles more before ground contact.
When introduced into brain slice cultures , these microglia-like cells changed their morphology to a ramified shape on the first day of the culture.
When investigating CSF lactate levels in neurodegenerative diseases , it is necessary to consider patients ' age and CSF glucose levels.
When investigating possible time trends in the microarray data , we have found no differential expression within a sampling period ( within-season effect ) .
When it comes to old age , we are witnessing almost revolutionary changes at the present time.
When items were residualized for their respective facets , @percent@ of them had significant ( p < @number@ ) residual age-correlations.
When judging on societal spending even melanoma patients opted for spending on ipilimumab in only @percent@.
When judging truth , older adults ' accumulated general knowledge may offset this perception of fluency.
When left unrepaired , UVB-induced DNA damage leads to accumulation of mutations , predisposing people to carcinogenesis as well as to premature aging.
When looking at each quality of life's domain we found that women reported higher scores of autonomy compared to men.
When loudness is also considered , the Qx was significantly greater for louder vowels , whereas its perturbation was significantly lower for louder vowels.
When LVOT-PG was measured during the strain phase of the Valsalva maneuver in @number@ non-obstructive patients , @number@ of those @number@ patients showed LVOTO.
When managed by an expert surgeon , a high-risk histological subtype should not be considered a contraindication for MIS.
When materials without IDS are compared , L showed significantly lower results than that of MR ( p = 0.035 ) .
When maternal problems were high , the amount of support offspring receive from their mother had a negative association with offspring depressive symptoms.
When measuring intervention effects , @number@ studies considered PROGRESS-Plus factors as control variables.
When minimal requirements needed to be defined , the indicator amino acid oxidation technique came into practice.
When miRNAs of the same family were combined , miR-132 and miR-134 family biomarkers demonstrated @percent@ and @percent@ overall accuracy , respectively.
When mothers had high problems , results indicate a negative association between depressive symptoms and physical health.
When MPCs were treated with aged rodent serum CCN1 mRNA increased by sevenfold and protein increased by threefold suggesting the presence of a circulating regulator.
When normalised for mitochondrial content by citrate synthase , mitochondrial respiratory capacity was similar in all groups.
When older adults ' were encouraged to orient at least some degree of attention toward the predictive information , learning occurred.
When opinion leaders advocate or adopt a best practice , others adopt too , resulting in diffusion.
When optimized to fit the Swedish population sample , the Lubiński model and two other models provided accurate predictive normal values.
When other disease-related variables were adjusted , the result remained substantially unchanged.
When OVM scores were compared with KayPENTAX normative thresholds , @percent@ of subjects were found to be above the threshold for soft phonation index.
When parents were born outside Europe , survivors less frequently used information from the Internet ( ORadj @number@ @percent@ CI @number@ @number@ ) .
When participants said \ "I don't know \ " or did not respond to an item , they received a standardized verbal prompt.
When participants were given feedback in Experiment @number@ both middle-aged and older adults benefited from repeated testing.
When partnership characteristics were included in the model , age was no longer related to SQoL.
When patients with a diagnosis of ICDs not otherwise specified ( ICD-NOS ) were included , the prevalence rate increased to @percent@.
When patients younger than @number@ years were compared to older patient groups , no difference in the probability of developing wound dehiscence was noted.
When performing surgery in older patients , both surgical outcomes and the maintenance of postoperative quality of life ( QOL ) are important issues.
When PHFs are treated with alkali , they untwist and form filaments with a ribbonlike morphology.
When premature senescence was induced by specific exogenous stimuli , concomitant Ets-1 upregulation was also observed.
When proven , these changes might function as a surrogate endpoint for cognitive and motor function in future therapeutic trials.
When putting an equal sign between mitochondria and bacteria , we find similarity between the mitochondrial and bacterial theories of cancer.
When rats were @number@ mo old , mean β-cell lifespan was @number@ mo vs. @number@ mo in rats with type @number@ diabetes vs. controls.
When recombination is rare , selection is expected to act chiefly on rare large-effect mutations , which purge genetic variation due to genome-wide hitchhiking.
When recommendations were followed , sites were much more likely to report clinical improvement ( @percent@ vs @percent@ , P < @number@ ) .
When recommended , @percent@ of mothers and @percent@ of fathers accepted pertussis immunization.
When relationship quality is ambivalent or negative , burden , conflict , and blame conspire , creating a destructive cycle.
When relationship quality is positive , mother-daughter dyads enjoy rewards and mutuality , even when conflict occurs.
When remembering past events or imagining possible future events , older adults generate fewer episodic details than do younger adults.
When response time served as a covariate , the age effect for accuracy was reduced.
When results were examined longitudinally , cumulative exposure was confounded with age as workers with the highest cumulative exposure were generally older.
When RMS concentrations exceed a certain threshold , cell compartments and cells are injured and destroyed.
When RV IVA was corrected for HR ( RV IVAc ) , it became independent of HR , age , BSA , and gender.
When scans were interpreted with computed tomography images , sensitivity and specificity improved for most readers but the differences were not significant.
When selecting impairment thresholds , one should consider the impact on the identification of MCI subtypes and the probability of misdiagnoses.
When Sirtuin @number@ levels were less than @number@ pg BDORT units , a high incidence of AIDS was also detected.
When Sirtuin @number@ was less than @number@ pg , the majority of the people had various degrees of tumors or other serious diseases.
When so ?
When some differences are found , we create sample weights that other researchers can use to adjust these differences.
When source information is bound together , it makes a memory episodic in nature.
When specific types of activity were examined , volunteering manifested the strongest association with lower levels of inflammation , particularly in the 70 + group.
When staff would transfer them , patients feared injury or felt badly when clinical personnel were injured during transfers.
When started at the age of @number@ and @number@ months , metformin delayed the first tumor detection by @percent@ and @percent@ , correspondingly.
When stenosis is clinically relevant , patients often describe activity-related low-back or lower-extremity pain , known as neurogenic claudication.
When stratified by comorbidities or number of biopsies we see an almost identical decrease in erectile function with time.
When stratified by gender , data show that for men physical health was only positively associated with younger age.
When stratified by sexual enjoyment , @percent@ enjoyed sex and this group had lower PFDI and PFIQ scores , reflecting less quality-of-life burden.
When studied across time we found that in 3xTg-AD mice , the compensatory phenomenon occurred in parallel in different regions of the brain.
When studying cause-specific mortality , we found the largest differentials in deaths from circulatory disease , whereas disparities in mortality from neoplasms were smaller.
When such damage is prolonged or not repairable , senescence , apoptosis or autophagy is induced.
When supine , compression leggings did not change any cardiorespiratory variables in either age group or thermal condition ( P > @number@ ) .
When supplementation is prescribed , about half of the elderly care physicians and a fifth of the general practitioners uses an insufficient dose.
When supplement use was considered , the effect was in the protective direction but was not significant.
When supplied in trans some truncated human ORF1 proteins suppress human L1 retrotransposition.
When supra-patellar bursitis is caused by degenerative disorders , the concept of viscosupplementation treatment may be effective by injecting hyaluronic acid into the bursa.
When telomeres are shortened to a critical length , they will initiate chromosomal instability ( CIN ) and may finally cause tumorigenesis.
When telomeres critically shorten , as often occurs with repeated mitoses or in response to oxidation and inflammation , cells may die.
When tested on ceramic brackets , all the wires exhibited an increase in friction ( t-test ; P < @number@ ) .
When that ability is compromised , the informal network of family and friends may not be a sustainable transportation option.
When the amount of available food is sufficient , these receptors transmit the signal allowing aging.
When the analysis was computed on the number of observations over time , and @number@ assessments considered , comparable results were obtained.
When the background noise becomes cognitively more demanding , there is a larger decline in speech perception , due to age or hearing impairment.
When the built-in software delineated an erroneous chorioscleral border in the B-scan images , manual segmentation was used.
When the caregiver was a child of the elderly receiving care , the Hans ' ZBI score was higher than that for the Korean Minority.
When the catheter has been present for @number@ weeks or longer , it should be replaced and the urine specimen collected through the new catheter.
When the developed platform was applied , MVs in stored blood units could also be monitored longitudinally.
When the easy test was first , participants in both age groups adopted a more stringent criterion on the harder test.
When the elderly suffer injuries , they have a decreased metabolic reserve to handle the stress required to recover.
When the Gini coefficient was considered , the highest drop in ICC was observed for financial abuse ( from @percent@ to @percent@ ) .
When the glycine and lysine levels were plotted , much higher correlation ( p < 0.001 ) was observed.
When the hard test was first , no criterion shift was seen.
When the intention was finished , younger adults efficiently deactivated their intention , but the older adults continued to retrieve their intentions.
When the low-frequency component which is the result of the Gaussian Filter application is eliminated , we can get only skin fine-structure.
When the mice were tested on hidden platform water maze , spatial learning memory was significantly impaired after @number@ months of age.
When the @number@ critically ill subjects receiving haloperidol intravenously were excluded , @percent@ of our subjects were women.
When the p22phox C242T polymorphism was compared with the mean ages and age groups , statistically significant associations were found.
When the papilla or the periampullary region is involved we choose to perform pancreaticoduodenectomy ; otherwise it is better to perform a local resection.
When the patients had significant maxillary retrusion , structural fat grafting was performed at the same time.
When the pressure to respond quickly was removed , search accuracy greatly improved for rare targets.
When the primes were noise vocoded , there was no release from informational masking for either younger or older adults.
When the programme decreases the bioenergetics level below certain value the cyclin E-Cdk2 becomes the target for p27.
When the replication machinery encounters a DNA roadblock , the outcome can be devastating if the obstacle is not overcome in an efficient manner.
When these cross-loadings were not included in the model , model fit notably worsened.
When these lines of communication are closed , network size is associated with greater risk for undiagnosed and uncontrolled hypertension.
When these options fail , surgery is indicated.
When these processes go awry , chromosomes missegregate.
When these two conditions are associated , professionals are even less attracted to work with old alcoholics.
When the shortcut and adaptability values increase , the complexity in the system dynamics becomes uncorrelated.
When the speed reached @number@ RPM or the HR reached the maximal training HR , the experiment was then terminated immediately.
When the trial ended , @number@ of the @number@ surviving participants were followed for @number@ additional years.
When the two models were combined , the correlation between metabolic syndrome and cognition was @number@
When the vision screening was completed , it was discovered that over @percent@ of the employees had visual deficits that were correctable.
When they did not agree about engagement , they each provided their perspective on what they believed had or had not occurred.
When the youths were age @number@ TL was assayed from a blood draw.
When they spoke about adherence , nurses presented an idealized image of the nurse-patient relationship , namely , the caring nurse and the trustful patient.
When they were used separately , both of them showed similar promotive effects on primordial follicles.
When the γ-H2AX foci which mark the DSBs are stained , individual breaks are detectible , making the assay suitable for situations requiring great sensitivity.
When this happens , they often try to exclude the unwanted memory from awareness , a process that relies upon inhibitory control.
When this neuropathy is accompanied by pain , it requires a specific treatment.
When this occurs , myonuclei can be increased or replaced by the adult stem cells of muscle , satellite cells ( SCs ) .
When this system is impaired by mutation of Vms1 , ubiquitin-dependent mitochondrial protein degradation , mitochondrial respiratory function , and cell viability are compromised.
When those participants known to have developed dementia during the follow-up period were excluded from the analysis of the baseline data these differences disappeared.
When treating older adults with multi-morbidity , practitioners should consider starting low-dose drugs so they can look for potential drug-drug and drug-disease interactions.
When tricyclic antidepressant and / or anticonvulsant cannot relieve PHN , opioids should be considered in some selected patients.
When tumors were measurable , we initiated treatment with control or siVASH2 mixed with atelocollagen , which enveloped the whole tumor.
When used in conjunction with existing clearance guidelines , denial of pain may lead to missed injury.
When used in multi-regression models , they reduced cord areas group variability by approximately a third.
When using a CO2 laser , additional cosmetic improvements are a result of removal and tightening of the photodamaged collagen in the superficial dermis.
When VHD is suspected , transthoracic echocardiography should be obtained first.
When volunteers were present at lunch , the average macronutrient and energy intakes increased , though not statistically significantly.
When we altered experimentally the selection pressure by antibody-mediated removal of neutrophils , we observed a significantly younger pathogen population in mice.
When we applied atrophy correction to our PET data , none of the above-mentioned correlations remained significant.
When we combined the @number@ performance measures , the relative difference was @percent@ ( @percent@ confidence interval = @percent@ , @percent@ ) .
When we consider the @percent@ slower , we can add the variables handgrip strength , and the presence of COPD.
When we examine CD4 subsets we also find a shift towards Th1 and cytotoxic CD4 ( ThCTL ) responses.
When we have knowledge to successfully intervene earlier , why would we not want to do so.
When we infected human skin equivalents , we observed entry only into unstratified keratinocytes or after wounding of fully stratified cultures.
When we mutated four amino acids within the region , the mutant VASH2 lost its pro-angiogenic activity.
When we overexpressed BACE1 in CHO cells stably transfected with human contactin-2 , we found increased release of soluble contactin-2 in the conditioned media.
When we tested UV-irradiated fluorescent protein vectors , the fluorescent protein was observed in NER-proficient cells , but not in NER-deficient cells.
When we train a classifier directly on incompletely labeled dataset , it performs ineffectively.
When women spoke to an HCP about their symptoms , most ( @percent@ ) initiated the discussion.
When young adults re-tell a story , they naturally produce more concise but sufficiently informative narratives.
When ε4 HTZ and HMZ were considered separately , there was a striking effect in HMZ ( p < 0.001 ) but not in HTZ.
Where appropriate , blinded studies examined in this paper were conducted using a variety of statistical procedures.
Whereas age-related volume reduction was mild in HC and absent in EC , iron content evidenced significant age-related declines.
Whereas aging affects cognitive and psychomotor processes negatively , the impact of aging on emotional processing is less clear.
Whereas a large number of IgM and IgG NAbs have a key role in tissue homeostasis , while others modulate cellular and enzyme properties.
Whereas a vaccine is available for prevention of shingles , its efficacy declines with age.
Whereas Aβ is viewed as critical for Alzheimer's disease pathogenesis , the role of other APP processing products remains enigmatic.
Whereas Betula includes rich information about e.g. cognitive functions , VIP contains information about e.g. lifestyle and health indicators.
Whereas CD56 ( bright ) cells are decreased in healthy elderly individuals , the CD56 ( dim ) subset is expanded.
Whereas , enhanced LPC was observed in the elderly in all conditions.
Whereas FcγRII ( CD32 ) expression remained unchanged , FcγRIII ( CD16 ) increased from low values before surgery to levels of controls 6months post-surgery.
Whereas GHRD mice show improved age-dependent cognitive performance , the effect of GHRD on human cognition remains unknown.
Whereas high dose radiation exposure causes DNA damage and gives rise to ionization to molecules of living cells by accelerating malignant tumor formation.
Whereas HK was associated with kidney function and several inflammatory markers , such associations were abolished or attenuated for the ratios.
Whereas in cortex this was accompanied by upregulated VGLUT1 expression , extracellular glutamate concentrations were decreased.
Whereas most young mice succumbed to clinical prion disease , all aged mice failed to develop clinical disease during their lifespans.
Whereas normal aging impairs specific aspects of language production , most core language processes are robust to brain aging.
Whereas p52Shc and p46Shc are ubiquitously expressed , p66Shc shows constrained expression.
Whereas palliative treatments are in use , the goal of blocking progression of motor and cognitive disability remains unfulfilled.
Whereas patient and prescriber barriers to deprescribing exist , resources and strategies are available that facilitate deliberate yet judicious deprescribing and deserve wider application.
Whereas patients assessed the importance for their everyday lives , physicians assessed the importance for patients ' medical care and patients ' everyday lives.
Whereas PEs disappeared for older-placebo participants for high-load lists , older-glucose participants retained their positive preference.
Whereas physical symptom count was associated with distress , occupational , and functional disability , worry count was only associated with distress.
Whereas polymyositis responds to immunosuppressant drug therapy , sIBM responds poorly , if at all.
Whereas proportions of nTreg cells declined with age , memTreg cells increased.
Whereas SAHF formation is shared by diverse cultured cell types under oncogenic stress , SAHF are cell-type-restricted under genotoxin-induced and replicative senescence.
Whereas selenium supplementation extends the number of population doublings , its deficiency impairs the proliferative capacity of WI-38 cells.
Whereas sestrin ablation resulted in broad reconstitution of immune function in stressed T cells , inhibition of individual MAPKs allowed only partial functional recovery.
Whereas some contribute to progressive cognitive deterioration , others lower the level of cognition but exert relatively stable effects over time.
Whereas subjective sleep responses predicted fragmentation of slow wave sleep ( SWS ) in HE individuals , this relationship was not evident in MCI patients.
Whereas tamoxifen displays partial ER agonistic effects in bone , aromatase inhibitors increase bone resorption and fracture risk.
Whereas the injurious effect of polypharmacy is established , that of low numbers of medications has not been fully ascertained.
Whereas the mechanism of hypoxia-driven angiogenesis is well understood , the link between inflammation-induced oxidation and de novo blood vessel growth remains obscure.
Whereas the ubiquitin-proteasome system is involved in the rapid degradation of proteins , autophagy pathways can selectively remove protein aggregates and damaged or excess organelles.
Whereas the underlying theoretical constructs could not be linked to the exploratory analyses of OLQ-13 , this was to some extent possible in OLQ-11.
Whereas the zeta potential of typical liposomes was @number@ mV , that of CPP-conjugated liposomes was @number@ mV.
Whereas we previously had no options , now we are faced with many choices.
Whereas young adults modulated memory specificity based on task demands , older adults did not.
Whereas younger adults recalled more specific events of short duration , older adults recalled more extended and summarized events of long duration.
Whereas younger participants tended to underestimate their attentional control and memory functioning relative to informant reports , older adults significantly overestimated their abilities.
Where available , clinically relevant outcomes were also assessed.
Where available , self-reported and test-based measures should be combined when trying to identify levels of frailty.
Where benefits have been shown , long-term studies are needed to confirm these benefits and verify the safety profile of DHEA.
Where evidence is available for the impact of CFTR modulatory therapy , namely ivacaftor on comorbidities in CF , this is highlighted.
Where feasibility was discussed , strong retention ( ≥70% ) and adherence ( ≥64% ) was reported.
WHERE NEXT ? : The identification of these seven novel genes has been important in unravelling the molecular mechanisms underlying ALS.
Where no alternatives exist , it is recommended to make short term treatments and to reassess periodically the indication.
Where people die has important implications for end-of-life ( EOL ) care.
Where possible , results were pooled and meta-analysis was conducted.
Where possible , we discuss the unique opportunities and challenges for advancement of regenerative medicine in China.
Where possible , we provide operational criteria to define functional and neural compensation.
\ "Where \ " spatial systems may be linked to cortico-cortical processing networks involving the posterior part of the dorsal visuospatial processing stream.
Where these are not available , patients go untreated.
Where these devices fit in the physician practice and consumer routine can be confusing , as scientific studies may be weak or lacking.
Where these differences reflect lack of knowledge or experience , they set the stage for developing curricula to help narrow these gaps.
Wherever applicable , we also discuss nuances and uniqueness of a Breg study in cancer to warn potential pitfalls.
Whether age-associated differences in hormone levels are causally related to cardiovascular disease , or are biomarkers reflecting accumulated ill-health remains under debate.
Whether alcohol abusers exhibit accelerated biological aging , as reflected in PBL-TL , has never been examined.
Whether and how AGEs may cause AD-like tau hyperphosphorylation and memory-related deficits is not known.
Whether and how Aβ and YKL-40 affect brain and cognitive changes in cognitively healthy older adults is still unknown.
Whether and how miR-132 contributes to pathology in these neurodegenerative diseases remains unclear.
Whether androgen deficiency also affects cardiovascular or bone biology in women during reproductive aging is still controversial.
Whether an understanding of these mechanisms will also help uncover mechanisms underpinning the ageing process itself is open to question.
Whether a period of room temperature hold ( RTH ) during RBC production enhances the RBC storage lesion has remained controversial.
Whether a reduced perception of self-motion contributes to poor walking speed adaptations in older adults is unknown.
Whether arterial stiffness is influenced by lifetime fiber intake is not known.
Whether a sex difference in intrinsic circadian period in humans underlies the difference in circadian alignment between men and women is unknown.
Whether asthma history influences job type or job changes among nurses is unknown.
Whether attachment errors are responsible for age-related oocyte aneuploidy is unknown.
Whether avoiding PIM listed on the PRISCUS list may potentially improve the quality and efficiency of healthcare is currently unknown.
Whether BG is performed in isolation or combined with other exercise programs seems to have no influence on such effects.
Whether bicarbonate levels independently predict the development of functional limitation has not been previously studied.
Whether biomarkers of kidney damage are prognostic for more severe outcomes is unknown.
Whether BRCA1 and BRCA2 germline mutation status affects treatment outcome remains elusive.
Whether BubR1 contributes to age-related deficits in hippocampal neurogenesis is yet to be determined.
Whether caffeine has long-term ketogenic effects or could enhance the ketogenic effect of medium chain triglycerides remains to be determined.
Whether CD8 + T-cell count is associated with CVD risk is not clear.
Whether CGRP protects against EPCs senescence is unknown.
Whether CHCHD2 gene mutations are involved in both of these diseases remains unclear.
Whether chronic HIV infection causes similar effects is currently unclear.
Whether chronic inflammation plays a causal role in cognitive decline in aging and neurodegeneration has not been established.
Whether cognitively impaired or not , few family reported drivers in this sample ( ∼2% ) retained a valid license.
Whether conventional hierarchical central commands sent by the brain to the heart alone explain all the interplay between these two organs should be reconsidered.
Whether current MS therapeutics impact this pathological driver of disease progression remains uncertain.
Whether decreasing incidence will contribute to reduced burden of dementia given the aging of the population is not known.
Whether depressive symptoms and sleep might help explain racial differences in endogenous pain facilitatory processes has yet to be determined.
Whether dietary fatty acids interact with genetic variants to modify circulating omega-3 fatty acids is unclear.
Whether due to evolutionary or ontogenetic factors , sleep and psychiatric disorders change with age.
Whether earlier intervention to reduce LDL-C could prevent aortic valve disease merits further investigation.
Whether early cardiac structural changes also associate with cognitive decline is yet to be determined.
Whether elevated RMR constitutes an early marker of health deterioration in older adult has not been fully investigated.
Whether elevations in these cardiac biomarkers are associated with decline in kidney function was evaluated.
Whether endogenous neurogenesis contributes to spontaneous recovery after stroke has not yet been established.
Whether ethnic-specific reference ranges for T and cFT might be appropriate in clinical practice requires further investigation.
Whether exogenous estrogen exposures in the early postmenopause affect Alzheimer risk or cognitive aging much later in life is unanswered by available data.
Whether exogenous testosterone is proatherogenic remains controversial.
Whether further advances in imaging , robotic surgery , and percutaneous mitral valve repair lead to even better outcomes remains to be seen.
Whether health literacy skills may be influenced by technological and social factors during ageing is unknown.
Whether hearing loss is a marker for early-stage dementia or is actually a modifiable risk factor for dementia deserves further study.
Whether HI is associated with broader downstream outcomes is unclear.
Whether HIV-infected people with elevated BP have excess AMI risk compared to uninfected people is not known.
Whether HIV is an independent risk factor for CVD in women has not yet been established.
Whether HIV itself is an additive and independent risk factor for cardiovascular disease ( CVD ) remains a central question.
Whether improved intensive care can contribute to improved outcome after ICH will be shown by data obtained in the coming years.
Whether incobotulinumtoxinA and other BoNTAs are equipotent is subject of debate.
Whether individual differences in language development in childhood predict differences in adolescent drinking behaviors has not been studied.
Whether inflammageing is a valid model for describing the ageing process or is the consequence of other mechanisms needs further discussion.
Whether information on previous lower extremity performance adds independent information to disability prediction compared to a single measure alone is unknown.
Whether klotho can counteract deficits related to neurodegenerative diseases , such as AD , is unknown.
Whether low levels of naive cells actually do associate with mortality has , however , not been tested in longitudinal studies.
Whether maximal cardiac output ( Qmax ) parallels this group-specific decline with age remains uncertain.
Whether maximum age changed over time was analysed taking into account increases in cohort size.
Whether measurements of inflammatory markers and cells from tissues collected in these two different ways are comparable is debatable.
Whether minimally invasive surgical techniques can reduce postoperative morbidity and mortality rates in elderly patients requires further evaluation.
Whether mitochondrial quality control ( MQC ) is altered in skeletal myocytes of old patients with CC is unclear.
Whether mitochondrial respiratory capacity per mitochondrion ( intrinsic activity ) in human skeletal muscle is affected by differences in mitochondrial variants is not known.
Whether MT-I and MT-II supplementation could inhibit skin ageing , especially photoageing , merits further study.
Whether multiple signals exist at AF loci has not been systematically explored.
Whether non-invasive measurement of AGE accumulation in the skin may reflect vessel function and vessel protein modification is unknown.
Whether normalizing serum 25 ( OH ) D concentrations in these patients improves outcomes will require testing in future clinical trials.
Whether older adults can compensate for their associative memory deficit by using memory strategies efficiently might depend on their general cognitive abilities.
Whether older persons with MetS should receive treatment and whether the current diagnostic criteria for MetS apply to older individuals need further investigation.
Whether optimization of sleep can ameliorate age-associated intramuscular or intermuscular adipose tissue warrants further studies.
Whether or not adolescence should be treated as a special period , there is now no doubt that the brain changes much during adolescence.
Whether or not an individual's drug metabolising capacity declines with advancing age is a vexing question.
Whether or not clinically relevant doses of sildenafil citrate cause hearing loss in normal subjects ( animals or humans ) is controversial.
Whether or not cognitive and MRI changes represent stable attributes of BD or evolve with time is still matter of debate.
Whether or not CTA can be used in HF patients is unknown.
Whether or not hypercholesterolemia warrants medical concern , and whether statins are beneficial among very old people , remain unresolved common clinical dilemmas.
Whether or not mitophagy depends on prior mitochondrial fragmentation by the canonical mitochondrial division machinery is controversial.
Whether or not these will be sufficient is a matter we will consider subsequently , using quality indicators and process analysis.
Whether or not they had a medical antecedent the Board made @number@ psychiatric diagnosis.
Whether other factors influence age at diagnosis is unclear.
Whether p.A152T confers a greater than expected propensity for tau pathology in these GRN carriers remains an open question.
Whether PA is associated with subsequent AD course has not been investigated.
Whether patient-reported measures of health , well-being , or quality of life respond differently to surgery in non-frail and frail individuals is unknown.
Whether peripheral hearing impairment is associated with accelerated rates of brain atrophy is unclear.
Whether PF is an early cause or marker of weight change in this population remains to be determined.
Whether phase angle is associated with frailty and mortality in the general population is unknown.
Whether physically active way of life affects these associations is unclear.
Whether protection can be enhanced to counteract the age-dependent decline in telomere integrity is a challenging question.
Whether proteinuria better predicts outcome than eGFR in stroke patients treated with intravenous thrombolysis ( IVT ) remains to be determined.
Whether rapamycin can be developed into an antiaging agent remains unclear.
Whether reducing triglyceride levels can lower the incidence of clinically significant mitral valve disease requires further study.
Whether reversible downregulation of physiological gonadotropin drive operates in vivo is unknown.
Whether sex or menstrual cycle influences cardiac ANS interfered by SD remained unclear.
Whether similar associations exist for in vivo tau pathology remains elusive.
Whether sleep is maintained or disturbed might explain why some individuals are able to handle a certain stress load while others develop a mental disorder.
Whether sleep might promote the occurrence of insight in older adults as well has not yet been tested experimentally.
Whether such an increase has any clinical relevance has not been addressed.
Whether such cells are monolithic , or define subsets of B cells with different functions is not yet known.
Whether such changes in redox signaling reflect primary age-related changes or are secondary to the fundamental mechanisms is unclear.
Whether sumoylation , particularly SUMO- @date@ conjugation , is involved in cardiomyopathy has not been investigated.
Whether TDP-43 pathology is merely an incidental finding in AD or actually contributing to the more severe clinical phenotype remains unresolved.
Whether the adverse effect of high presentation levels extends to processes subsequent to speech intelligibility , such as memory , is unknown.
Whether the dengue virus , the Flaviviridae family as with HCV , enhanced the HCV clearance remains unclear and needs further exploration.
Whether the different trypsins degraded type II collagen was tested in vitro.
Whether the effect of light on cognitive brain function changes with aging is unknown , however.
Whether the inhibition of this pathway is truly responsible for the anti-diabetic and cancer effects of the drug in mammals remains to be established.
Whether the KOP-Q can be used in other countries is unknown given the cultural and language differences.
Whether the maximum length of life increases with time was also investigated.
Whether there still is a case to treat surgical menopausal women with estrogens for a longer or shorter period of time remains to be tested.
Whether the risk of AMD is increased by exposure to sunlight , cardiovascular risk factors , and diet is more controversial.
Whether these alterations are related to a common pathogenic mechanism or develop independently in patients with COPD remains an open question.
Whether these approaches could offer safe symptom relief and possibly mediate beneficial joint remodeling in early OA are possibilities that merit further investigation.
Whether these are early features of PD will require a longitudinal study. © @number@ International Parkinson and Movement Disorder Society.
Whether these associations are causal is yet to be demonstrated.
Whether these associations are consistent across ethnicities with a non-European ancestry is unknown.
Whether these benefits extend to the more intense and prolonged exercise associated with marathon running is unclear.
Whether these changes reflect cognitive heterogeneity or differences in disease severity is still unknown.
Whether these conditions represent subsequent steps in the causal pathway from knee-OA to changes in gait is still not clear.
Whether these effects of exercise training may delay further cognitive decline in patients diagnosed with MCI remains to be demonstrated.
Whether these findings can be extended to human hypertension remains unclear.
Whether these heart-brain correlations could be fully explained by the central autonomic network is unknown and needs further exploration.
Whether these manifestations are linked to the lung alterations or are independent complications of smoking remains unclear.
Whether these microvascular adaptations explain the well known associations of fetal and infant characteristics with cardiovascular disease in later life should be further studied.
Whether these radiological lesions correspond to irreversible histological changes is still a matter of debate.
Whether these relationships are similar for the aging population remains unclear.
Whether these trajectories change their shape , and how and why if they do , is important theoretically too.
Whether the severity of olfactory impairments in aMCI patients parallels those in AD has not been clearly established.
Whether they differ with respect to cerebellar pathologic changes has yet to be studied.
Whether this abnormality predicts mortality in treated HIV infection and can be reversed by early antiretroviral therapy ( ART ) remains unknown.
Whether this applies to aged human muscle is unknown , nor is it clear whether these changes are caused by sedentary behavior.
Whether this association is independent from increased prevalence of comorbidity , causing both anemia and reduced physical function is yet under debate.
Whether this compensatory response persists or declines with the onset of cognitive impairment can only be addressed using a longitudinal design.
Whether this difference is related to estrogen has not been well-characterized.
Whether this ethnic difference is associated with similar changes in the concentration of K + is unclear.
Whether this function is impaired in humans of advanced age is unknown.
Whether this interaction can be extrapolated to food-based sources of SFAs , specifically dairy foods , is unexplored.
Whether this is a result of active HIV-related neurodegeneration is unclear.
Whether this is due to self-selection or predisposition is not well understood but merits further study.
Whether this leads to long-term alterations of the brain's structure associated with cognitive decline remains unknown.
Whether this limits isometric muscle performance remains to be assessed.
Whether this occurs among older adults ( > 60 years ) is currently unknown.
Whether this pathway is conserved in mammals remains unknown.
Whether this peripheral dynamic is reflected by a similar pattern in the brain remains unknown.
Whether this reflects a better health status requires further investigation.
Whether this tremor worsens during young and middle age is unknown.
Whether to use antiplatelets or anticoagulants in stroke prevention in CeAD-patients is still a matter of debate.
Whether treating this disorder of sleep results in improvement in cognition remains to be determined.
Whether treatments that target insomnia-related complaints might reverse these markers of inflammation in older adults with insomnia is not known.
Whether TREM2 is altered in prodromal AD remains unknown.
Whether vitamin D supplementation may have a role in the prevention of diabetes in high-risk populations remains to be seen.
Whewellite was the more common encrustant.
Whichever method used , an emphasis on safety is of the utmost importance.
Which factors attribute to both the fall risk and the fracture risk ?
Which falls result in a fracture ?
Which has the biggest impact ?
Which might be the neural bases for these behavioral differences ?
Which model is more accurate is unknown.
Which preventive actions should be implemented in aging patients with diabetes ?
Which tools are available to predict falls and fractures ?
While additional research is needed to test and refine the intervention , we need to find more creative ways to enhance respite services.
While aerobic exercise training ( AEX ) is generally an effective therapy to improve gait speed , individual responses are highly variable.
While age and gender had no effect on ANL , a significant , but weak , correlation was found between ANL and hearing loss.
While age and gender were included as confounders in the basic model , income was included in the second model as a potential mediating variable.
While age had no impact on any aspect of cognitive failures , overall and specific dispositions varied between the two populations.
While age reduced overall cell yield and adipogenic potential of all MSC populations , osteogenesis and clonogenicity remained unchanged.
While age-related declining patterns differ for different activities , the top five most popular leisure activities are similar for all age groups.
While age-related diseases have been the subject of over a century of intense investigation , until recently , physiological ageing was considered unavoidable.
While aging is associated with increased knowledge , it is also associated with decreased semantic integration.
While aging is inevitable , the effect of aging on different areas of spine is of clinical significance.
While all cells are inevitably progressing towards death , many disease processes accelerate the aging process , leading to senescence.
While all participants scored in the normal range on the Mini-Mental State Examination , the TBI group scored lower than the non-TBI group.
While all seven cytokines scored high on PC1 , only IL-1Ra and IL-10 scored high on PC2.
While a minority of patients forwent care , it was dental care that was mainly forgone by both home-dwellers and institutionalized patients.
While animal data suggest a protective effect of caffeine on cognition , studies in humans remain inconsistent.
While annealing resulted in the retention of some oxidation potential , post-irradiation melted UHMWPEs had reduced fatigue strength due to the crystallinity loss during melting.
While anodal tDCS improved response latencies in large arithmetic problems , it decreased solution rates in small arithmetic problems.
While an overall @percent@ response rate was achieved , representation from five of @number@ Health Boards was not available.
While antipsychotic use remained high ( @percent@ ) , little antipsychotic use was deemed inadequate by indication.
While a number of candidate gene studies have been carried out , results remain inconclusive.
While a number of training studies have focused on training perceptual and cognitive function , only very few are specifically targeted at improving multisensory processing.
While aortic aneurysms often remain clinically silent , the morbidity and mortality associated with aneurysm expansion and rupture are considerable.
While arresting cell cycle , p53 ( under certain conditions ) can inhibit the mTOR pathway.
While awaiting further prospective evidence from clinical trials , we endorse an active treatment of DCIS as the standard of care.
While Aβ is present at all sites of deposition from @number@ months of age , it increases markedly from @number@ months onward.
While Aβ production is accelerated in familial AD , increasing evidence indicates that impaired clearance of Aβ is responsible for late-onset AD.
While biological factors condition fertility , so do social expectations.
While both baseline EFV and CAC displayed significant correlations with systemic inflammation markers , biomarkers were not predictive of the progression of CAC or EFV.
While brain research has generally focused on mean performance , little is known about neural correlates of cognitive IIV.
While Candida is the most prevalent agent in such infections , Aspergillus is at the second order.
While cartilage T2 values were weakly associated with age and gender , they had the highest correlations with BMI.
While causing senescence in regular cell density , etoposide failed to cause senescence in contact-inhibited cells.
While CCRCs have experienced significant growth over the last few decades , very little is known about the quality of care CCRCs provide.
While change is always challenging , this new practice paradigm could improve both oral health and health outcomes of patients seen in the dental office.
While changes in muscle function explain part of the age-related reduction in functional performance , ~60% of the deficit remains to be explained.
While chromatin regulation and lamin B1 down-regulation have been implicated as senescence effectors , functional interactions between them are poorly understood.
While circumventing the major disputes associated with human ESCs , iPSCs offer the same advantages and , in addition , new perspectives for personalized medicine.
While clinical experiences have informed us that cranial bone thickness varies with age.
While clinical trials are under way , impaired metabolism has been documented in RBCs stored in several additive solutions ( ASs ) .
While cognitive illness representations were associated directly to burnout , the association between emotional representations and burnout was mediated by emotion-focused coping.
While cognitive-motor interference in dual-task activities is well established , it is still unknown how such interference is influenced by concurrent visual challenges.
While cognitive reserve ( CR ) delays neurocognitive decline , CR's relationship with apathy has never been studied.
While comparing the effect of medication between the groups , we monitored the adverse effects of both drugs.
While considerable research has targeted physical performance in older adults , less is known about the ability to rise from the floor among community-dwelling elders.
While cosmetic sunscreen products form an essential element of sun protection strategies , they are not adequate when damage has already been inflicted.
While cross-sectional , these results add weight to recent data emphasising the importance of adequate sleep in physical and mental health.
While currently optimized for mice , the GGP could be adapted to any preclinical animal model.
While current pharmacological therapies alleviate the symptoms associated with cardiac deterioration , heart transplantation remains the only therapy for advanced heart failure.
While current systems work well , they still have several limitations.
While dealing with older patients , it is crucial not to attribute all the physical symptoms to PD.
While decreasing overall , risk of all-cause hospitalization remains higher among HIV-infected than uninfected individuals and is strongly influenced by the presence of an ARD.
While defects in splicing could lead to changes in protein isoform levels , they could also impact gene expression through nonsense-mediated decay of intron-retained transcripts.
While dementia was still the most common syndromal diagnosis , the proportion of subjects diagnosed with milder memory problems increased to @percent@.
While DJ-1 expression was decreased in the substantia nigra of mice administered with MPTP , its degradation was largely attenuated in MMP3 knockout mice.
While each hypothesis alone has its shortcomings , a synthesis of the two can explain much of what we know about the etiopathology of PD.
While environmental factors have been evoked to explain this conundrum , the nature of these environmental factors remains unexplained.
While episodic memory declines with age , metacognitive monitoring is spared.
While essential functions of the m-AAA protease for neuronal survival have been established , its role in adult glial cells remains enigmatic.
While estimates for heritability increased in all measures over time compared to baseline , these increases were statistically non-significant.
While estrogen is critical for the maintenance of bone formation , the mechanism ( s ) of this effect remain unclear.
While exoribonuclease treatment is widely used to degrade linear RNAs and enrich circRNAs in RNA samples , it does not efficiently eliminate all linear RNAs.
While extensively studied for their impact in younger populations , there is comparatively limited evidence about the effectiveness of these agents in older patients.
While females and males show no significant differences in predicted DNA methylation age , ovariectomy results in significant age acceleration in females.
While fluorescence spectra of laurdan appeared red-shifted with decreasing membrane stiffness , fluorescence anisotropy and rotational correlation times were reduced with increasing membrane fluidity.
While focused primarily on elders and their caregivers in Scotland , the topic is a globally important one.
While FSH supplementation stimulated GCs growth and prevented luteinization in vitro.
While further study is needed , this work creates an easy-to-administer tool that may be generalizable to other populations.
While gait variability may reflect subtle changes due to aging or cognitive impairment ( CI ) , associated brain characteristics remain unclear.
While gender differences in CO ( @number@ ) R are described in adults , there are no such data in children.
While global chromatin conformation studies are emerging , very little is known about the chromatin conformation of human telomeres.
While global T2 time significantly decreased towards the heart basis , female volunteers had significant higher T2 time irrespective of myocardial region.
While GMV and CT generally decrease with age , GMD increases and shows the strongest age-related effects , while GMM shows a slight decline overall.
While gray matter thickness and overall brain mass were reduced in AD compared to ND control groups , overall capillary density was not different.
While group classification using resting-state data was highly above chance ( approx.
While hearing aids are recommended for people with age-related hearing loss , many with impaired hearing do not use them.
While homecare is the most economic form of care , it also appears to be the most difficult to maintain and develop.
While hypertension and aging are established factors contributing to arterial stiffness , the role of inflammation in stiffening of the arteries is less well understood.
While IL-15 , which protects potentially harmful CD8 BACKGROUND : There has been concern about the growing off-label use of testosterone.
While impairments in memory recall are apparent in aging , older adults show a remarkably preserved ability to selectively remember information deemed valuable.
While important objections have been raised against the prudential life span account , it continues to dominate scholarly debates.
While increased sensitivity to acidosis for cell survival in 2-dimensions was not observed , clonogenic proliferation and 3-dimensional spheroid growth in particular were greatly reduced.
While , in different years , the prevalence was @percent@ in @number@ @percent@ in @number@ and @percent@ in @number@
While individuals @number@ and older accounted for @percent@ of the population in @number@ they accounted for @percent@ of all acute care service spending.
While individuals of African descent suffer a disproportionate burden of hypertension and its complications , they have been underrepresented in genetic studies.
While in male mice the impact of ageing on adipose tissue remodelling is well characterized , the effects in female mice remain largely unclear.
While in rodents , good responses had been found for this type of immunization , positive results in larger mammals are missing.
While isolated atrial amyloidosis can develop with aging , the presence of preamyloid oligomers ( PAOs ) in atrial tissue has not been previously investigated.
While it becomes increasingly clear that proteasome-dependent proteolysis is a major player , the topology and molecular mechanisms of nuclear protein homeostasis remain largely unknown.
While it influences all body systems , it is particularly important for the brain and is typically characterized using measures of brain electrical activity.
While it is important for such growth to continue , prevention via sensible photoprotection methods still remains the best current management option.
While it is known that the Vegfa-Notch cascade plays a central role , the transcriptional hierarchy controlling arterial specification has not been fully delineated.
While it is postulated to be an independent risk factor , a possible mechanism is local or systemic inflammation.
While it is well known that working memory functions decline with age , the functional reasons for this decline are not well understood.
While juveniles showed frequent and prolonged gaze alternations , only adults adjusted their behaviour based on the reliability of the human experimenter after being rewarded.
While KRIBB11 is an inhibitor of HSF1 , we found that KRIBB11 induced Mcl-1 degradation in an HSF1-independent manner.
While life expectancy was @number@ in 19th century , it is now @number@
While logical , this is extremely challenging as the molecular mechanisms that drive aging are still unknown.
While major weight loss has been demonstrated to ameliorate hyperleptinemia , obese people show a poor tendency to achieve lasting success in this field.
While many DERs annotated to non-exonic sequence ( @percent@ ) , most were similarly regulated in cytosolic mRNA extracted from independent samples.
While many hypotheses have been provided as to the cause of the disease , the exact mechanisms remain elusive and difficult to verify.
While many interventions have been advocated for use in this population , evidence for their effectiveness is unclear.
While many nutrition screening tools have been developed , few have been evaluated for use in older adults in the community setting.
While many regionally diverse molecular and electrophysiological changes are observed , not all of them correlate with juvenile stress-induced behavioral disturbances.
While many studies have identified thousands of loci associated with age , few have differentiated between linear and non-linear DNAm trends with age.
While many such modifications are well documented , others , such as histone tail cleavage are less understood.
While mean BMI increased linearly from @number@ to @number@ years of age , %BF did not change between @number@ and @number@ years.
While mean response amplitudes were moderately greater in younger adults , older adults had much greater within-subject variability.
While measurements of choroid using optical coherence tomography show altered thickness in aging and macular disease , detailed histopathologic and proteomic analyses are lacking.
While mechanisms are complex , these conditions are often accompanied by elevated angiotensin II ( Ang II ) .
While mechanistic understanding of PD is advancing , a treatment with well tolerable drugs is still elusive.
While memory and language skills are maximally affected , intellectual function is also compromised in MTLE.
While menopause and andropause may both play a role , 50age was the most critical factor across gender.
While men's CVD mortality has decreased since the 1980s , women's CVD mortality has climbed until @number@
While mobility disorder is universal at a high burden of frailty , neither mobility nor balance dysfunction is sufficient to fully define frailty.
While mortality tended to be higher in the older population , none of the secondary analyses indicated worse outcome for the older patients.
While most of the cases affect people aged between @number@ and @number@ years , approximately @number@ % of cases occur in older patients.
While most of them offered a single cause for their symptoms , some offered more complex multi-causal explanations.
While most patients have asymptomatic diverticulosis , around one in five develops symptomatic diverticular disease.
While most patients with differentiated thyroid cancer have a good prognosis , aggressive disease is more common in the elderly and disease-specific mortality is higher.
While most previous centenarian studies have used convenience samples , ours is population-based and likely more valid for comparison in applied settings.
While most studies focus on overall life satisfaction , considering life satisfaction as multidimensional is essential to gaining a complete picture.
While most studies ( @percent@ ) claim effectiveness , objective measures were only utilized in @number@ studies ( @percent@ ) .
While motor performance remained comparable before and after the TSST stress session in both age groups , the associated neural strategies differed between groups.
While mounting evidence implicates ROS in the AD etiology , clinical trials with antioxidant therapies have not produced consistent results.
While much is known about intracellular Hsp70 , scant data exist on circulating Hsp70 in the aging context.
While much is known about the establishment and maintenance of cell polarity , its role in aging and age-related diseases remains to be fully addressed.
While much is made of the data deluge in science , neuroimaging represents the leading edge of this onslaught of \ "big data \ ".
While neurological signs were common , they were not universal and should not be considered an inevitable component of ageing.
While neuropsychiatric symptom measures are helpful , more sensitive assessments delineating the specific behavioral and linguistic deficits accompanying FTD are needed.
While neuropsychological tests have been identified for the early prediction of Alzheimer's disease , this has not been established for prediction of all-cause dementia.
While NLaz has metabolic functions similar to ApoD , the regulation of GLaz expression upon aging is the closest to ApoD in the aging brain.
While no correlation was found between objective measures of memory and olfactory performance , subjective complaints of route finding difficulty was associated with UPSIT score.
While no differences were observed on the alerting score , both orienting and executive attention scores showed a more protracted developmental curve.
While no mediators of area SES-walking associations were identified , several environmental attributes explained the associations of educational attainment with walking.
While no patient survey was conducted , anecdotal evidence suggests that patients are satisfied with the GRS procedure and the outcomes of treatment.
While normal aging results in overall brain atrophy , lower omega-3 index may signal increased risk of hippocampal atrophy.
While no study separately reported atrophy by gender , a number tested for gender effects and @number@ studies reported higher atrophy in males.
While @number@ studies were performed without TC as aging , @number@ of them employed thermocycling at varying number of cycles.
While numerous sources of variation potentially affect the precision of different methods , the impact of sample size cannot be overlooked.
While numerous studies have characterized the former abilities in infancy , expectations about emotions have gone relatively unexplored.
While older adults performed worse on the medication management test than younger adults , the results were not statistically significant.
While older adults show higher nonresponse rates on sexual orientation than younger adults , the nonresponse rates have significantly decreased over time.
While online groups have been shown to be helpful , submissions to a message board ( vs. live conversation ) can feel impersonal.
While only @percent@ were found to live alone , @percent@ stated that they felt abandoned to some degree.
While only preliminary data , the results suggests the potential importance in determining the d-Ser levels in plasma and their potential role in physiological response.
While oocyte quality is known to decay with somatic aging , it is not a given that different biological functions decay concurrently.
While our genomes are essentially static , our microbiomes are inherently dynamic.
While overexpression of SorCS1 reduced γ-secretase activity and Aβ levels , the suppression of SorCS1 increased γ-secretase processing of APP and the levels of Aβ.
While p38MAP kinase is involved in transcription , mTOR is involved in message stabilization.
While pain is a common symptom among older adults , it often is underdiagnosed and undertreated.
While @percent@ of participants perceived sex to be important , only @percent@ discussed sex with their providers since turning @number@
While @percent@ of patients had a high sinusoidal density of CD83-positive cells , @percent@ demonstrated a high density of CD83-positive cells in the periportal tract.
While @percent@ of respondents believed the risk of dementia could be reduced , @percent@ were very confident that they could achieve this.
While phosphorylation at Ser87 is enhanced in synucleinopathies , it inhibits -synuclein oligomerization , and influences synuclein-membrane interactions.
While plasma amyloid-β ( Aβ ) is known to be elevated in DS , its relationship to cognitive functioning is unknown.
While polypharmacy was seen in @number@ % of patients , only @number@ % concurrently used ≥3 psychotropic medications.
While pooled library screens are effective tools , erroneous barcodes can potentially be generated during the production of many barcodes.
While positron-emission tomography ( PET ) amyloid imaging has altered the landscape of differential diagnosis for age-associated neurodegenerative disorders , costs are prohibitive.
While prevalent , the status of self-neglecting individuals remains largely unclear , in particular within community-dwelling populations.
While previous studies provide an indication that these patients may benefit from surgical treatment , the substantial variability in treatment underscores the opportunity for improvement.
While previous SWATH-mass spectrometry studies have shown high intra-lab reproducibility , this has not been evaluated between labs.
While prior studies support the test-retest reliability of memory instruments over brief intervals , follow-up testing in clinical settings typically occurs at least one-year later.
While promoting safe driving and the prevention of crashes and injuries , this intervention could ultimately help older adults maintain or increase their transportation mobility.
While provincial and regional level ' big picture ' planning is a necessity , study participants highlighted the critical role of local perspective and expertise.
While psychological stress has been implicated in the process of telomere shortening , associations with activity of physiological stress systems have remained elusive.
While rationing has also been addressed by health economists , there are three puzzling observations.
While reduced lymphocyte count has been associated with age , other studies found no change in WBC counts with age.
While reduced , needs for clinical PTSD services remain among aging combat veterans.
While researching her memoir , the author discovered that the questions about her deafness that she most needed to answer were her own.
While resveratrol cytotoxic action was due to its pro-oxidant properties.
While risk of bias and heterogeneity limited the strength of our meta-analysis , our results are consistent with those seen in this field of research.
While routine post-procedural CXR seems avoidable , IF should be considered mandatory.
While sagittal alignment is essential in operative strategy , the coronal plane should not be overlooked , as it may affect the osteotomy technique.
While salt sensitivity cannot be ascribed exclusively to these factors , perturbation of these processes promotes hypertension during high-salt intake.
While scholars and policymakers have investigated the causes and consequences of low fertility , they have neglected a related issue : advanced parental age.
While SC hydration and skin surface pH are affected by the subject's age , TEWL and sebum production show only minor variations.
While several compounds exhibited strong activities in individual assays , compound @number@ emerged as a promising multi-target lead for the further structure-activity relationship studies.
While several of these causal factors for functional decline in the oldest old are inevitable , some may not be , such as depression.
While several studies reported positive effects , a number of methodological weaknesses were identified and the overall quality of included studies was poor.
While shifts in target location decreased performance of both age groups , this effect was more pronounced in the older group.
While significant correlations in females were mainly positive , significant correlations in males were exclusively negative.
While socio-demographic and behavioral characteristics were also obtained through questionnaire.
While some countries provide high quality care for the disabled elderly , in others this is not the case.
While some display compassion and empathy , others draw away and wish to maintain their distance from them.
While some evidence is available for adults , less was available for youth.
While some predictors of well-being after stroke were identified , the determinants of well-being remained largely unexplained.
While some skills are natural and acquired through practice , other skills would benefit from insights from the fields of management.
While some studies have demonstrated progressive age-related gray matter reductions in schizophrenia , other studies have not found evidence of progression.
While some technology tools have been introduced , the information and technology needs of LDCs in particular are not well understood.
While SST and NAFL proved equally safe , SST was associated with signi cantly lower pain scores in all three treatment sessions.
While structural properties in healthy and diseased WM have been extensively studied , relatively little is known about the physiology underlying these structural characteristics.
While studies from wild vertebrates support such sexual conflict , it remains unexplored in humans.
While surgical lifting remains the gold standard , there has been a growing demand among patients for less invasive techniques.
While symptoms can be relieved by decreasing doses or number of anti-PD medications , this may lead to an unacceptable worsening of motor function.
While taking study supplements , enrolled men visited their SELECT site and were evaluated for dementia using a 2-stage screen.
While technically data exchange could be implemented technically , uptake was impeded by a lack of working procedures.
While technological opportunities multiply rapidly , clinical applications are rare as the technological potential of IATs remains inadequately translated into dementia care.
While the ACP-managed group demonstrated a significantly greater length of stay than the control group , some confounding was likely.
While the anabolic effects of androgens are well known , the effects of estrogens on skeletal muscle anabolism have only been uncovered in recent times.
While the anti-cancer properties of resveratrol have been extensively investigated , the anti-adipogenic and osteogenic effects of resveratrol are also gaining considerable interest.
While the contribution of NO-mediated mitochondrial fragmentation to neurodegenerative diseases seems clear , the mechanisms by which NO causes fragmentation are uncertain and controversial.
While the demographic-healthcare time bomb we're faced with should have been obvious years ago , the need for positive action is upon us.
While the effects of bilingualism on cognitive functions across the lifespan are well documented , less is known about the neural substrates underlying differential behaviour.
While the electrophysiological responses to unexpected sounds have been extensively studied , behavioral distraction has received relatively less attention until recently.
While the etiology is still unknown , however , genetic factors , aging , life style , and environmental factors may be involved.
While the expected life-time increases dementias will show a pandemic nature.
While the formation of nucleoside AGEs has been demonstrated previously , no extensive studies have been performed to assess the genotoxicity and immunogenicity of DNA-AGEs.
While the G32T mutation was detected in all @number@ positive control cases , all other patients were negative for the @number@ mutations.
While , the independent living in the dispersed ethnic community was associated with smaller American social networks and higher levels of cultural alienation.
While the involvement of club cells in IPF pathogenesis is unclear , their migration has been associated with lung fibrosis.
While their behavior is tightly coordinated , very little of the crosstalk involved is known.
While the life spans of HIV-infected patients have been prolonged with successful cART , the spectrum of cognitive alterations observed in these patients has broadened.
While the likelihood of reporting sexual health concerns tended to decrease with age in women , the opposite was seen in men.
While the major monocyte and dendritic cell subsets did not change numerically with aging , activation of specific cell types was altered.
While the mortality in the elderly declined between @number@ and @number@ the neonate sepsis mortality increased dramatically , especially among male neonates.
While the Ne / ERN was associated with the processing of errors in general , the Pe amplitude was modulated by detected errors only.
While the neurodegeneration and symptomology of PD develop chronically over the years , post-stroke neuronal death and dysfunction develop rapidly in days.
While the Nintendo Wii Stillness test showed a high reproducibility , a systematic learning effect between successive sessions was observed for the Agility test.
While the Northwestern China has the topographic and sunshine advantages , which help the residents there more probable to reach @number@ years old.
While the @number@ groups experienced similar relative sexual function decreases at @number@ years , younger men had worse interim decreases at @number@ year.
While the number of inmates and releasees has risen , their HIV seroprevalence rates have fallen.
While the patients in such cases do well clinically , there is a lack of long-term angiographic followup.
While the prevalence and morbidity of COPD in the elderly are high , it is often undiagnosed and thus undertreated.
While the prevalence of acute rejection is constantly decreasing , prevention of transplanted organ long-term function loss is still challenging.
While there are many overlapping treatment indications for each of the devices mentioned above , some modalities offer distinct advantages making proper patient selection essential.
While there are no known limits to the age at which men can father children , the effects of advanced paternal age are incompletely understood.
While there are not similar requirements for physicians , a few hospitals have introduced mandatory age-based evaluations.
While the recommended doses result in physiological hormone levels , higher doses do not hasten or increase the desired changes and are a health risk.
While there is a paucity of comparative trials to date , a critical exploration of these technologies is worthwhile.
While there is consensus on the definition of frailty , there is no agreement on how it should be measured.
While there is evidence of poor health among rural older adults , little research has examined how they perceive and define health.
While there is growing interest in the rights of older persons with dementia , relatively little empirical data exists regarding their actual interactions in courts.
While there is much extant literature on its quantification and correlation to comorbidities , a quantitative gold standard for analyses in this regard remains undefined.
While there is no decisive evidence to choose between them , the latter appears more likely.
While there is some evidence that stereoacuity improves with age , little is known about the development and maturation of coarse stereopsis.
While there is substantial evidence tying low SES to increased disease risk and reduced life expectancy , the underlying biology remains poorly understood.
While there was no eyebrow whitening in @percent@ of the subjects , level @number@ whitening of eyebrows was observed in @percent@ of the subjects.
While there was no statistically significant difference across gender , Caucasians had AMDs documented more frequently than African Americans ( p < @number@ ) .
While there was substantial classification discordance based on clinical cutoff employed , no significant predictors of this discordance emerged.
While there were no serious adverse events , @number@ of @number@ noncompleters withdrew due to musculoskeletal complaints.
While these interventions show promise , their potential pitfalls are discussed herein.
While these measurements have yielded new insights into brain development and pathologies , they have yet to be thoroughly investigated in the spinal cord.
While these observations appear contradictory , recent work and technological advances demonstrate that metabolic deregulation during aging is potentially biphasic.
While these questions have not yet been clearly resolved , several groups of possible theories have been published on this topic.
While the specific sites of differences were mostly idiosyncratic to a twin pair , a proportion involving GABA signalling were common to all ALS individuals.
While the SSNA response to whole-body cooling is impaired with ageing , SSNA can be further increased by a non-thermoregulatory stimulus.
While the statistics of smoking prevalence in Poland are available , data on smoking initiation and its social correlates are still poorly described.
While the strong baseline association between FBB SUVR and EM declined over @number@ years , the association between EM and HV became stronger.
While the TM interface shadow length did not correlate with age , the TM interface shadow area increased with age.
While the wild type WRN relocalized to the nucleoli after @number@ hours recovery from etoposide-induced DSBs , the mutant WRN remained mostly in the nucleoplasm.
While this entity is frequently overlooked , there is often an underlying cause that is correctable.
While this is a major success , with increasing age comes an increased risk for disease.
While this is to be celebrated , older people are more likely to develop healthcare conditions that can restrict their lives and independence.
While this may be related to an age-dependent reduction in whole-body sweating , no study has clearly delineated at what age this occurs.
While this property is well established for the aberrantly folded protein , the physiological function of PrP ( C ) remains elusive.
While this trend is something to celebrate , it also brings with it challenges for health care systems.
While this was a plausible model then , new data over the intervening years suggest a need to modify these concepts.
While t-PA and endovascular thrombectomy can recanalize the occluded vessel , good clinical outcomes are not uniformly achieved.
While transporting cholesterol is a primary function , apoE also regulates amyloid-β ( Aβ ) metabolism , aggregation , and deposition.
While treatment improves progression-free survival , most patients relapse.
While treatment with PGE ( @number@ ) antagonists repressed PGE ( @number@ ) -induced cellular senescence , increasing intracellular cAMP accelerated cellular senescence.
While unable to select a PaParp deletion strain , we succeeded in the generation of PaParp overexpressors.
While underlying mechanisms for age-related treatment effects remain unclear , vagally mediated cardiovascular function may play a key role.
While understanding speech in noise is a challenge for everyone , it becomes increasingly difficult as we age.
While unitization of verbal materials improves associative memory in older adults , less is known about the impact of visual integration.
While uptake was higher amongst younger individuals , once enrolled , older individuals were more likely to adhere to online interventions for cancer-related distress.
While useful , this can influence performance differences between groups due to perceptual biases and limitations on task performance.
While US testosterone prescriptions have tripled in the past decade ( @number@ ) , debate continues over the risks and benefits of TRT.
While valuable for understanding ORF1p function , these in vitro approaches do not provide any information on ORF1p self-interaction in the context of mammalian cells.
While women experience a notable decrease in oocyte production in their late thirties , the effect of age on spermatogenesis is less well described.
While women have a significantly higher rate of hip fracture among the community-dwelling seniors , men have a significantly higher rate among nursing home residents.
Whilst evidence for the use of these agents in older women is limited , there appears to be no signal for any difference in efficacy.
Whilst much is known regarding the impact of age on adaptive immunity , innate immunity has received far less attention from immune gerontologists.
Whilst only @percent@ indicated they would seek help from no-one , @percent@ would delay seeking help.
Whilst poverty , chronic illness and psychological issues are discussed in this paper as separate issues , they are interconnected.
Whilst the organ is large in juvenile animals , it begins to involute around puberty due to the suppressive effects of sex steroids.
Whilst this is a consistent issue amongst adults of all ages , the burden of chronic disease is greatest amongst older adults.
White Africans are more likely to have sleep durations that are associated with negative health outcomes.
White Africans reported more short sleep duration than the other population groups , while there were no racial or ethnic differences in long sleep.
White blood cells recovered from buffy coat were used for DNA fragmentation test.
White males were at particular risk for experiencing more severe alcohol problems.
White matter b0 SNR reproducibility was on average @number@ ± @percent@ with no significant MRI site effects.
White matter changes are one of the several aging brain alterations.
White matter changes on MRI were defined as hyperintensities > 5mm on FLAIR images.
White matter complexity , brain volumes and cognitive performance were measured at both @number@ and @number@ years.
White matter damage was expressed as severity of white matter hyperintensities ( WMHs ) .
White-matter disruption was more widespread in ε4 + individuals but more focal ( posterior predominant ) in the absence of an ε4 allele.
White matter FA decreased with age at a similar rate in both DS and control groups.
White matter hyperintensities and brain infarcts were measured using fluid-attenuated inversion recovery magnetic resonance imaging as a marker for vascular pathology.
White matter hyperintensities may represent an independent source of impairment and / or may interact more fundamentally with \ "primary \ " AD pathology.
White matter hyperintensities ( WMH ) are associated with hypertension.
White matter hyperintensities ( WMH ) are commonly seen in the brain of healthy elderly subjects and patients with several neurological and vascular disorders.
White matter hyperintensities ( WMHs ) refer to areas of hyperintense signal on T2- or proton density-weighted brain magnetic resonance imaging.
White matter hyperintensity volume ( p < 0·0001 ) and cognitive performance ( p < 0·0001 ) also differed by ATN group.
White matter hyperintensity volumes were quantified.
White matter integrity was analyzed by conventional magnetic resonance imaging and diffusion tensor imaging.
White matter integrity was quantified using a widely accepted measure , fractional anisotropy ( FA ) .
White matter lesion load ( WMLL ) was quantified from MRI T2-weighted FLAIR images.
White matter lesions , also termed White Matter Hyperintensities ( WMH ) , on T2-weighted MR images , are common in the elderly population.
White matter lesions play a role in cognitive decline and dementia.
White matter lesions ( WML ) are associated with dementia and are common in brain ageing.
White matter lesions ( WML ) are common in brain aging and are associated with dementia.
White matter lesions ( WML ) disrupt connections between gray matter ( GM ) regions which in turn changes their activation patterns.
White matter lesions ( WMLs ) are frequently found in patients with LLD.
White matter microstructure and resting-state functional connectivity ( FC ) of task-relevant brain regions were assessed using multimodal magnetic resonance imaging ( MRI ) .
White matter microstructure is under strong genetic control , yet it is largely unknown how genetic influences change from childhood into adulthood.
White matter staging could play an important role in a better understanding and the treatment of cerebrovascular contributions to brain aging and dementia.
White matter T2 hyperintensities were characterized by size and location by two neuroradiologists.
White matter tracts displaying a significant decrease in fractional anisotropy values were the corpus callosum , the anterior thalamic radiation and the inferior fronto-occipital fasciculus.
White matter ( WM ) change plays an important role in age-related cognitive decline.
White matter ( WM ) comprises about half of the brain and its dysfunction is implicated in many brain disorders.
White matter ( WM ) continues to mature through adolescence in parallel with gains in cognitive ability.
White matter ( WM ) lesion volumes and total brain , gray matter , and WM volumes were computed.
White matter ( WM ) occupies a large volume of the human cerebrum and is mainly composed of myelinated axons and myelin-producing glial cells.
Whitening effects were measured by tyrosinase inhibition assay , and by melanin formation test in B16 / F10 melanoma cells.
White participants had higher energy-adjusted MedDiet scores but lower HEI-2005 scores than did black participants.
White participants were not found to have greater prevalence or higher mean score on any risk factor.
White participants with higher SES had greater brain volumes than all other groups ( albeit within normal range ) .
Whites and blacks showed similar findings as the overall population.
Whites had a strong correlation of ≥0.5 for @number@ items , while Blacks had strong correlations for only @number@ items.
Whites reported more drinks / week than African-Americans.
Whites were more likely than African Americans to fall into the health provider plus clergy and physician plus mental health provider classes.
White women with @number@ to @number@ term pregnancies compared with @number@ term pregnancy had higher odds of longevity.
White women with shorter LTL had higher risks of mortality.
WHODAS-II and DUSOCS perform best in measuring disability and social support respectively.
WHO-Five well-being index was used to measure psychological well-being.
Whole blood DNA methylation analysis has been proposed to be a risk marker for cancer that can be used to target patients for preventive interventions.
Whole blood DNA methylation profiles were measured by Illumina Human Methylation450K Beadchip.
Whole body and calf bioimpedance ( Hydra @number@ ) methods were utilized with subjects in the supine position.
Whole-body arginine-NO and protein metabolism were measured using stable isotope techniques , and baseline values were compared with healthy controls.
Whole body bone mineral density was measured by dual-energy X-ray absorptiometry.
Whole-body citrulline production was elevated in CF indicating preserved mucosal function.
Whole-body cryotherapy ( WBC ) is a procedure which is more and more often successfully applied in medicine.
Whole-body insulin sensitivity ( M / I ) was evaluated by an clamp.
Whole body insulin sensitivity was significantly lower at a more advanced age , with lowest values reported in the type @number@ diabetic patients.
Whole-body kinematics were also recorded with motion analysis.
Whole body motion data while performing STS were collected from @number@ young , @number@ elderly and @number@ elderly subjects with difficulty in STS.
Whole body plethysmography was used to assess the HVR and HCVR the day after SH exposure ended.
Whole-body protein synthesis and muscle protein fractional synthesis rate increased similarly.
Whole-body sweat loss was measured from changes in nude body weight.
Whole-body sweat rate ( WBSR ) was calculated from measurements of evaporative heat loss.
Whole body vibration ( WBV ) is a simple and convenient exercise.
Whole-body vibration ( WBV ) training in elderly may improve muscle strength , muscle power and postural control.
Whole brain analysis resulted in no significant test-retest differences at any of the sites with any of the DTI metrics.
Whole-brain comparisons showed increased temporal and frontal activation in the older group for low-level motion but no differences for biological motion.
Whole-brain global and regional atrophy measures were obtained from same-session structural scans.
Whole-brain g-ratio maps were computed and analyzed voxel-wise.
Whole brain homogenates ( minus cerebellum ) were collected for examination of brain oxidative markers , caspase-3 and acetylcholinesterase ( AChE ) activity.
Whole brain interindividual variations of CT and CG were similar to that in the literature.
Whole-brain network analyses remain the vanguard in neuroimaging research , coming to prominence within the last decade.
Whole brain pvSH volumes yielded high inter-rater reliability ( ICC = .99 ) .
Whole brain WMH volumes , especially deep WMH volumes , showed a non-significant trend for a positive association with MIC-1 / GDF15 serum levels.
Whole-cell TRPV5-mediated channel activity was recorded in HEK cells coexpressing TRPV5 and sKL or membranous Klotho ( mKL ) .
Whole-diet interventions , measures of bacterial activity , and studies in metabolically at-risk subjects were identified as potential gaps in the evidence.
Whole-exome resequencing facilitates identification of recessive disease genes.
Whole-exome sequencing identified a homozygous truncating mutation in Synaptojanin @number@ ( SYNJ1 ) .
Whole exome sequencing identified two novel mutations in ERCC6 that had not been previously reported.
Whole-exome sequencing in independent large pedigrees identified cosegregating STX1B mutations predicted to cause an early truncation or an in-frame insertion or deletion.
Whole-exome sequencing revealed biallelic missense alterations of BRF1 in three families.
Whole-exome sequencing was performed in @number@ patients from the same family and was integrated with linkage analysis.
Whole exome sequencing ( WES ) was performed with the patients ' DNA.
Whole-genome and exome sequence data can be cost-effectively generated for the detection of rare-variant ( RV ) associations in families.
Whole mount retinas and paraffin sections were marked immunohistochemically with antibodies against the main components of the blood basement membrane.
Whole saliva ( one sample per each person ) was collected in the daytime ( @time@ or @time@ - @time@ ) .
Whole trabecular marrow samples were ground in a sterile mortar and pestle and cellularity and fat content determined.
WHOQOL- BREF and Satisfaction and Self-assessment Questionnaire ( SSQ ) were completed by subjects up to @number@ months after treatment.
WHO reference standards were used to assess growth disruptions of height , weight , and BMI.
WHtR ≥0.6 significantly increased outpatient costs by + 79€ and total costs by + 189€.
WHtR was the indicator most strongly associated with hypertension ( OR = 2.97 ; @percent@ CI @number@ to @number@ ) .
Why ?
Why , after @number@ years of intensive research , is adherence to treatment still an issue ?
Why chromosome segregation errors are more common in oocytes from older females remains poorly understood.
Why complications such as retinopathy may paradoxically precede the onset of type II diabetes.
Why did cells evolve an anti-cancer mechanism that arrests , rather than kills , would-be tumor cells ?
Why does cancer risk increase as we age ?
Why do humans live longer than other higher primates ?
Why do some surgeons retire ( or not ) , and perhaps more importantly , when should some surgeons retire ?
Why do we not invest more in educating our future geriatricians ?
Why do women live longer than men ?
Why follicular melanocytes are more sensitive to aging influences ?
Why intensive insulin therapy may initially worsen retinopathy.
Why IVF pregnancy rates decline sharply after age @number@ is unknown.
Why melanomas tend to originate from epidermal rather than follicular melanocytes ?
Why multiple follicular melanocyte sub-populations exist ?
Why RGCs degenerate in low-pressure POAG remains poorly understood.
Why some individuals develop one disease rather than the other is not clear.
Why these diseases manifest in aged individuals and why distinct disorders share strikingly similar emergence patterns were until recently unsolved enigmas.
Why this would be more apparent in men than women remains to be clarified.
Wicked problems can have different solutions , so it is critical to capture the full range of possibilities and interpretations.
Wide-field images were normalized and thresholded to a level of @percent@ brightness to emphasize collagen structure.
Wide geographic variations are observed , possibly linked to ethnicity.
Wide glucose excursions should be considered and HbA1C should be interpreted cautiously when making treatment changes based on HbA1C.
Widely studied wound healing agents are those derived from either natural sources including plants and animals or chemical synthesis.
Wide-range microRNAs analysis ( @number@ microRNAs ) was performed by quantitative real time polymerase chain reaction.
Wider application of AFIRs may further reduce health disparities among US older adults.
Wide resections are not needed ; it is important to remove completely the disease.
WIDER IMPLICATIONS OF THE FINDINGS : Age of G-1 PLUS @date@ medium used to culture human embryos affects birthweight of the respective newborn.
WIDER IMPLICATIONS OF THE FINDINGS : Our findings bring a new focus on the morphology and development of germ cells during the SEC in human.
WIDER IMPLICATIONS OF THE FINDINGS : These findings suggest that telomere length and telomerase activity may be considered as indicators for progression of ovarian decline.
WIDER IMPLICATIONS OF THE FINDINGS : We are not the first study to show a relationship between fertility and CMs.
Widespread and profound reduction in MT contrasted with local FA decreases paralleled by MD increases.
Widespread cellularity changes occur in younger HIV + individuals and diminish with aging and duration of HAART.
Widespread damage to mitochondria causes cells to die because they can no longer produce enough energy.
Widespread heritability of neuroanatomic traits was observed , suggesting that brain structure is under strong genetic control.
Widespread implementation of this approach would require work to address potential inequalities.
Widespread reduction in white matter mean diffusivity , however , was apparent visibly on the quantitative attenuation coefficient maps compared to healthy control subjects.
Widespread use of electronic health records ( EHRs ) among all provider types is foundational to delivery system transformation.
Widespread use of new and more effective treatment probably explains much of the increased survival.
Widespread vascular calcification is a ubiquitous feature of aging and is prevalent in association with several atherosclerotic diseases.
Widowed individuals in @number@ especially women , reported fewer social and financial difficulties than their counterparts in @number@
Widowhood is included as a stressful life experience that may introduce an additional nonshared source of variability in CES-D scores.
Widowhood is often associated with decreased mental health.
Wiedemann-Rautenstrauch syndrome ( WRS ) is a rare autosomal recessive disorder that includes premature aging phenotype at birth.
Wilcoxon signed-rank and Wilcoxon rank-sum tests were utilized to compare feature values across transducers and patient demographics , respectively.
Wilcoxon signed-rank tests compared the changes in the outcome variables between groups.
Wild Plum imparts optical brightness and fluorescence and can be used as an ingredient in cosmetic formulations.
Wild-type and canonical transient receptor potential ( TRPC ) 6 ( - / - ) mice were exposed to chronic hypoxia to induce HPH.
Wild type and mutated ( exon @number@ deletion ) EGFR-expressing cells responded similarly to cisplatin by showing MAPK-mediated EGFR phosphorylation.
Wild-type human syntaxin-1B but not a mutated protein rescued the effects of stx1b knockdown in zebrafish.
Wild-type klotho contributes to a significantly increased lifespan ; however , Klotho gene variants differ significantly between newborns and elderly.
Wild-type larvae / flies reared on AR-supplemented food survived the various cell stresses much better than those reared on control food.
Wild-type transthyretin is inherently an amyloidogenic protein , but its contribution to the formation of amyloid fibrils remains unclear in familial amyloid polyneuropathy patients.
Will aging research lead to novel therapies toward chronic disease , prevention of disease or be targeted directly at extending lifespan ?
Will antidiabetic biguanides increase lifespan in humans ?
Will employers be prepared to accommodate an aging workforce , especially in times of economic recession ?
Will health benefits be retained ?
Will individual baby boomers demonstrate the ability to prepare financially for their retirement ?
Will it work ?
Will physical demands remain manageable ?
Will , purpose , and volition have long been viewed as either causes of behavior or of no direct consequence to behavior.
Will reference equations based on the Lubiński model and optimized to a Swedish and to a Polish population allow for interpretable comparisons ?
Will the human species outlive the cockroach ?
Will this cause any harm to her fetus ?
Will this ceiling ever be lifted ?
Wine and curry showed higher stainability than water , recording higher deltaE ab values than the clinically perceptible difference level of deltaE ab @number@
Wines aged in oak were the best valuated during all aging time , but the differences were not always significant.
WinPepi ( version @time@ ) was used for descriptive analysis.
Winthrop University Hospital began using CPOE in @number@
Wip1 expression was significantly elevated by LPS treatment.
Wip1 is a nuclear phosphatase induced by many factors and involved in various stresses , tumorigenesis , organismal aging , and neurogenesis.
Wip1's role in BBB integrity has not been thoroughly investigated.
Wireless inertial sensors can accurately measure numerous walking and balance parameters but these measures require evaluation of reliability in PwMS.
WIREs RNA @number@ 8 : e1404. doi : @number@.1002 / wrna.1404 For further resources related to this article , please visit the WIREs website.
WIREs RNA @number@ 8 : e1413. doi : @number@.1002 / wrna.1413 For further resources related to this article , please visit the WIREs website.
Wisdom and experience , dependency and bereavement undoubtedly characterise old age.
Wisdom was assessed with the performance-based Berlin Wisdom Paradigm , with the remaining measures being mostly self-report.
Wishful coping - an avoidance / escape strategy - was linked to poorer quality of care.
WISW was hypothesized to reflect autonomic function in subjects without peripheral neuropathy.
With 18-month-olds they used more action-oriented approaches , whereas with 24-month-olds they increased their use of need-oriented approaches.
With ablative laser systems , the superficial layers of the skin are ablated , including epidermal and superficial dermal actinic damage.
With accelerating age , skin functions deteriorate due to structural and morphologic changes.
With acromegaly , the risk of malnutrition may also increase.
With added evidence from sperm bank samples , this decrease was found to be attributable mainly to changes in morphology assessment criteria.
With a differential diagnosis that encompasses vulvar disorders and infectious and noninfectious causes of vaginitis , accurate diagnosis is the cornerstone of choosing effective therapy.
With advanced age comes a heightened prevalence of chronic diseases.
With advanced age , skin is prone to degenerate in response to damage.
With advanced aging , main components of the kidney are altered , including blood vessels , glomeruli and tubulointerstitium.
With advances in modern health care , the average age of the general population is ever increasing.
With advancing age , a decline in the main sensory modalities including touch sensation and perception is well reported to occur.
With advancing age most aspects of the peptidergic regulation of energy balance are altered.
With advancing age participants reported fewer future plans and less optimism.
With advancing age , skeletal muscle function declines as a result of strength loss.
With advancing age , synapses in various hippocampal subfields exhibit impaired long-term potentiation , an electrophysiological correlate of learning and memory.
With advancing age , the ability of humans to detect and discriminate odors declines.
With advancing age , the balance between the amounts of old bone removed and new bone formed during the remodelling process becomes negative.
With advancing age , the functional reserve of many organs tends to decrease.
With age , a decline in attention capacity may occur and this may impact driving performance especially while distracted.
With age , a significant reduction in the number of mature oocytes and embryos obtained after follicle puncture and fertilization has been identified.
With age , cardiac performance declines progressively and the risk of heart disease , a primary cause of mortality , rises dramatically.
With age comes an increased risk for chronic mental health disorders.
With age , even though human HSCs increase in number , they have decreased self-renewal capacity and reconstitution potential upon transplantation.
With age , if the spleen is present and germinal centers are functional , innate IgM memory B cells are remodelled and accumulate somatic mutations.
With ageing body fat increases and total body water as well as lean body mass decrease.
With ageing , LOXL expression decreases , thus participating in the loss of skin elasticity.
With ageing populations , it becomes increasingly important to understand the determinants of cognitive ability among the elderly.
With age , IPA assumes different forms , and many older women actively choose to make the best of their situations.
With age , iron accumulates in brain frontal cortex regions and may contribute to the risk of AD.
With age macrophages become bloated with cellular debris including Aβ , however , their increasing numbers fail to stop Aβ accumulation.
With age , neurodegenerative changes in the brain of OXYS rats become amplified.
With age , significant changes in the function and composition of mature blood cells are observed.
With age , sleep also changes profoundly , with more sleep fragmentation , earlier awakenings and less slow wave sleep as its main features.
With age , structural and functional changes can be observed in human cornea.
With age , such leftward bias decreases.
With age the ability to understand speech in multitalker environments usually deteriorates.
With age , the frequency of pregnancy decreased.
With age , the human lens undergoes morphological , biochemical and physical changes leading to opacification.
With age , the level of insoluble extracellular matrix increases leading to increased stiffness of a number of tissues.
With age , the odontoblast layer is reduced in width , and mitochondrial elements converge around large clusters of autofluorescent lipofuscin deposits.
With age , the refraction demonstrated a significant hyperopic shift ( r = @number@ p < @number@ ) .
With age , the respondents preferred animal fats ( p < @number@ ) and vegetable fats ( p < @number@ ) .
With age , we observed a global loss of DNA methylation of approximately @percent@ , but an increase in methylation at some CpG islands.
With age , WM CVR response becomes greater and faster , which is opposite to the changes seen in the GM.
With aggressive risk factor management for comorbidities and less toxic antiretroviral medications , the burden of multimorbidity in HIV-infected persons can be reduced.
With aging , a general decline in immune function is observed leading to immune-senescence.
With aging and menopause muscle weakness , physical fragility and mobility limitations are also expected.
With aging and reduced physical activity , there are decreases in muscle creatine , muscle mass , bone density , and strength.
With aging and the accumulated effects of environmental stresses , the RPE can become dysfunctional and die.
With aging , an impairment of the homeostatic systems occurs and an alteration of circadian system regulation has been demonstrated.
With aging , arterial wave speed increases due to the stiffening of arterial wall , and also related to arterial disease.
With aging , both IVDs and EPs undergo degeneration.
With aging , customary gait patterns change and energetic efficiency declines , but the relationship between these alterations is not well understood.
With aging endothelium-independent vasodilation decreased while endothelium-dependent vasodilation remained mainly unchanged.
With aging , epidermal homeostasis and barrier function are disrupted.
With aging , insulin resistance and sarcopenia in skeletal muscle are induced , resulting in skeletal muscle aging.
With aging , muscle tissue homeostasis is progressively disrupted and the ability of MuSCs to repair injured muscle markedly declines.
With aging of the population , it is becoming an increasing problem in Croatia.
With aging population and development in imaging technology , many more elderly with early-stage lung cancers are being diagnosed than in the past.
With aging populations , European countries face difficult challenges.
With aging , the amount of ATR astigmatism was increasing.
With aging , the chaperone function of α-crystallin decreases , with the concomitant accumulation of water-insoluble , light-scattering oligomers and crystallin-derived peptides.
With aging , the existence of nonviable myocardium in the infarct area can induce fatal ventricular arrhythmia more than @number@ years after the original MI.
With aging the immune system undergoes significant age-related changes.
With aging , the lumbar RoF decreased by @number@.7° , whereas the pelvic RoF compensated for this effect and increased by @number@.0°.
With aging , various hormonal and kidney changes occur , both affecting water homeostasis.
With aging visual feedback becomes increasingly relevant in action control.
With aging , we found reduced numbers of alveolar macrophages , cells essential for lung homeostasis.
With aging , women lose both lean mass and height.
With a globally aging population , the burden of care of cognitively impaired older adults is becoming increasingly concerning.
With a greater focus on prevention through better screening and more active treatment , the number of people with end-stage kidney disease can be reduced.
With a growing aging population , our skills and areas of expertise are of high value to numerous industries.
With a growing population of diverse older adults , there is a need for incorporation.
With alignment of the epidemic curves locally before aggregation of cases , slight age-specific differences in the timing of infection became apparent.
With all these anti-Abeta approaches in clinical testing , we will know in few years if the Abeta hypothesis of AD is correct.
With a long-term interest in interventions that promote animal-wide health improvement , we sought to define exercise options for Caenorhabditis elegans.
With a median follow-up of @number@ months ( range , 5-227 months ) after auto-SCT , @number@ patients were still alive.
With a mobile agent's characteristics of easy adaptability to heterogeneity and autonomy , the problem of heterogeneous network environments can be tackled.
With an aging global population , chronic respiratory diseases are becoming a more prominent cause of death and disability.
With an aging population , degenerative musculoskeletal conditions will become more prevalent with significantly increasing costs to society over the next several decades.
With an aging population , however , there are a significant number of patients who have other comorbidities that preclude surgical resection.
With an aging population , incidence of these fractures will only increase.
With an aging population it is expected that the prevalence of AK will further increase.
With an aging population , more and more individuals are developing neurodegenerative diseases and there are few treatment options at the present time.
With an aging population the problem is expected to increase further since the prevalence of malnutrition increases with age.
With an aging , rapidly expanding and industrializing global population this value will continue to rise.
With an average age of @number@ years , urology is one of the oldest surgical specialties.
With and without correcting for confounders , no significant relationship was found between PASIPD or peak aerobic capacity and the MetS.
With an ever-increasing number of elderly individuals in the world , a better understanding of the issues associated with aging and the environment is needed.
With an expert in the field , we developed a quality assessment questionnaire to rate the quality of the studies included in this systematic review.
Withania somnifera is one of the most valued plants and is extensively used in Indian , Unani , and African systems of traditional medicine.
With an increased reproductive lifespan , the fitness costs of premature aging are higher and longer telomeres will be favored by selection.
With an increasingly aged population worldwide , the need for the prevention of AMD is rising.
With an increasingly older society , there will be an increased need for medical and surgical treatment of osteoarthritis.
With an increasing number of MS components , the prevalence of AF did not change.
With an increasing older adult population in Ghana , its burden is likely to increase.
With an individually tailored approach , elderly females benefit from minimally invasive techniques.
With an open jaw posture , speed quotient decreased for females and open quotient increased for females but decreased for males.
With a @number@ months average follow-up [ 6-20 ] , no cases of infection or mechanical complication was reported.
With a @percent@ dextrose-based solution , these percentages are @percent@ at age @number@ year to @percent@ at age @number@ years.
With a @percent@ false-positive rate , the genetic score alone detected @percent@ incident cases , the Framingham risk model @percent@ , and together @percent@.
With appropriate adaptation to local , country-specific circumstances , the roadmap can be translated to other countries.
With appropriate care of age associated comorbidities these treatment modalities are feasible and effective in the geriatric population.
With appropriate training , CHWs can collaborate as team members with primary care providers and with non-medical providers to improve the quality of care.
With a progressively aging population , the annual incidence of hip fracture is expected to increase substantially.
With a push toward aging in place , maintaining optimal physical functioning is crucial.
With a rapidly aging society , geriatric mental health is emerging as important public health concern.
With a rapidly aging society it becomes increasingly important to counter normal age-related decline in cognitive functioning.
With a sample of @number@ Chinese older people , we conducted two focus groups and @number@ in-depth interviews in Mandarin or Cantonese.
With a short-duration cue ( Exp.
With a simultaneous evaluation of the individual-level and division-level influences , it was found that the average division of TM / CAM use increased significantly.
With a specific focus on histone acetylation , we will discuss recent research in the field of epigenetic mechanisms of learning and memory.
With a successful intervention , this figure should drop to @percent@.
With better understanding of the inflammatory and destructive process in the pathophysiology of COPD , several new therapeutic targets have been identified.
With biological training , the in silico model captured the overall in vivo behavior and highlighted certain critical issues.
With bisphosphonate therapy , the BAP decreased , and the elevated ALP decreased to normal range levels.
With blocked retrieval in Experiment @number@ both types of old items instead elicited equivalent FN400 and LPC old / new effects.
With body composition it is possible to divide human body in compartments on the basis of different physical properties.
With CA an increase in elastic fibers was observed , whereas with RF no alteration was observed.
With cancer survivorship on the rise , long-term chemotherapeutic side effects are becoming more prevalent and attention to untoward oral complications cannot be understated.
With careful attention and augmentation of follicle transfer techniques , a natural end result is possible.
With careful monitoring , bacille Calmette-Guérin therapy is safe even in elderly patients.
With careful screening , short-term follow-up of living elderly donors demonstrated stable remaining kidney function even in those with mild and controlled hypertension.
With changing demographics , the number of persons with dementia will increase rapidly.
With China's gender imbalance and increasingly severe male marriage squeeze , patterns of intergenerational support in rural areas are likely to undergo significant change.
With continuous neocortical surface area maps , we confirmed the anterior-posterior gradient of genetic influences on cortical area patterning demonstrated in animal models.
With declining usage of vitamin E supplements , the population should be monitored for changes in vitamin E status and related health outcomes.
With depletion of follicle numbers , inhibin B is reduced with consequent reduction in theca DHEA.
With depressive symptoms excluded the strongest predictors were poor psychological well-being , hearing impairment , illiteracy , and gender.
Withdrawal of psychotropics and a systematic reduction of polypharmacy resulted in an improvement of cognition.
Withdrawal of psychotropics reduced fall rate ; a prescribing modification programme for primary care physicians reduced fall risk.
Withdrawing these medications is challenging because of their propensity for causing dependence and rebound insomnia.
With each cell division , somatic cell telomeres progressively wear and shorten , leading to cell senescence.
With effective antiretroviral therapy , HIV has become a chronic disease , and life expectancy among HIV-infected persons is approaching that of HIV-uninfected persons.
With eight-muscle insertions , the perineal body was a strong , irregular fibrous node that guarded the levator hiatus.
With enhanced understanding of these molecular pathways , drugs and devices used to treat aging skin can be more precisely tuned.
With epoxomicin , soluble p62 / SQSTM1 associated with proteasomes and p62 / SQSTM1 aggregates contained inactive proteasomes , ubiquitinated proteins , and autophagosomes.
With existing prevalence of high risk factors in Pakistan , the low CRC incidence may be an artifact.
With extensive simulation studies , we showed that the proposed method performed better than the existing methods , particularly for diseases with large heritability.
With extra care and attention to the special needs of this population , nuclear medicine departments can successfully study patients less than @number@ y old.
With follow-up she developed insidiously progressive visuospatial and visuoperceptual deficits , correlating with progressive atrophy in bilateral visual areas.
With further adjustment for financial status , HR was reduced by @percent@ in men who ate with others two times a day.
With further coaching , @percent@ participants demonstrated proficiency by their third onsite screening.
With further follow-up measurements , this research would contribute to the development of patient-specific models that assist radiologists in predicting skeletal integrity with aging.
With further testing , this innovative intervention may prove effective in addressing some of the most challenging aspects of dementia care.
With further validation , the assay might be also applicable to XP diagnosis.
With future waves of data , we will be able to examine LGB older adults ' drinking trajectories over time.
With global aging population , age-related cognitive decline becomes epidemic.
With goal-directed treatment , a treatment goal would first be established and choice of treatment determined by the probability of achieving that goal.
With Golgi-Cox impregnation , we also observed declined dendritic complexity and the loss of dendritic spines in striatal MSNs of DJ-1-deficient mice.
With greater longevity , a critical question becomes whether or not our memories endure across the life span.
With HFD complex I and IV protein expression decreased ( P < @number@ and P = @number@ respectively ) .
With higher difficulty , the variations in transitions were lower and constricted around low activity level transitions.
With higher IQ , cortical expansion is completed at a younger age ; and once completed , surface area decreases at a higher rate.
With impaired microvasculature , a lack of vascular endothelial-derived trophic factors and decreased cerebral blood flow cause the atrophy of neural structures.
With improvement of our understanding of ARHI , treatment other than with amplification will be hopefully possible in the long term.
With improvements in healthcare and extended life expectancy , it is becoming more apparent that osteoporosis affects men and can have serious consequences.
Within a group of elderly individuals , followed up for @number@ years , EBV-positive or HHV-6-positive PBL increased in those who developed clinical AD.
Within all regions and countries , prevalence strongly increases with age and is higher in men than in women.
Within- and between-group comparisons were made to evaluate changes by age and correlations were carried out to evaluate the relationships between all parameters.
Within both tasks and for all groups , stochastic fluctuations were lowest where the deterministic influence was smallest.
Within categories of alcohol intake , GCF and TBV were positively associated.
Within CD4 T cells , its secretion is restricted mainly to T follicular helper ( Tfh ) cells and Th17 cells to a lesser extent.
With incongruent trials , monolinguals activated the right middle frontal gyrus , whereas bilinguals relied upon the left inferior parietal lobule.
With increased life expectancy and longevity with HIV , older adults may particularly be at risk of this double burden.
With increased life expectancy , people need more education about healthy aging.
With increased life expectancy , women will spend over three decades of life postmenopause.
With increased participation in overhead sports in an aging population , the incidence of elbow injuries has risen.
With increased severity of hypogonadal status , participants were significantly older while their BMI was substantially similar.
With increase in age , there was an upward trend in caries prevalence and mean DMFT.
With increase in aging population and increased prevalance of coronary risk factors including diabetes mellitus , more people with multivessel coronary artery disease are diagnosed.
With increasing age , BAT decreases and body weight increases.
With increasing age , cognitive control processes steadily decline.
With increasing age cognitive performance slows down.
With increasing age human steroid hormone profiles change substantially , particularly following menopause in women.
With increasing age , physiologic changes and comorbidities have to be considered.
With increasing age , reaction times in the Stroop interference task are usually slowed.
With increasing age , the patient showed descriptively a deterioration of the joint situation.
With increasing age , there was a trend toward a lower fertilisation rate.
With increasing age , the SP length , effective length , and width increased.
With increasing age the vitamin D status is deteriorating.
With increasing experience , this procedure can be performed successfully and safely in selected high risk patients.
With increasing fracture risks due to fragility , osteoporosis is a global health problem threatening postmenopausal women.
With increasing ILT age the dissection energy of the underlying intima-media composite continuously decreased and the anisotropic dissection properties for that composite vanished.
With increasing OA incidence , more senior people are facing heavy financial and social burdens.
With increasing safety concerns , there is a significant need to optimize anticholinergic use in the vulnerable population.
Within each comorbidity category ( @number@ @number@ @number@ @number@ 4 + ) , the mHAI was still widely distributed and further stratified mortality.
Within each drug class , some medications have lower risk of falls.
Within each group , a positive linear correlation was observed between circadian period length in physiology and in fibroblast gene expression.
Within each group , correlations of FTSTS and TUG were similar for each of the variables examined.
Within each group , propofol caused significant decreases in SBP compared with preinduction values.
Within each group , QOL subgroups were similar in age , sex , and duration of disability.
Within each of these domains , we propose three clinical features that contribute different levels of diagnostic certainty.
Within each sex , memory performance and HVa were not different by APOE ε4 status at any age.
Within each theme , participants identified barriers that were adaptive challenges and facilitators that were examples of adaptive leadership.
Within endothelial and smooth muscle cells , diverse but important triggers that range from oxidized lipids to β-amyloid seem to stimulate autophagosome formation potently.
Within-group analyses showed that none of the arterial stiffness measures changed with RT or RT + CR.
Within group comparisons were tested using chi-square tests with post hoc pairwise comparisons.
Within-group percentage of change differences were not different between groups for FSR , FBR , or net balance ( P ≥ @number@ ) .
Within-group precision did not differ between evaluation methods.
Within high job demands , lower physical ability was associated with increased injury risk.
Within identical levels of acoustic detail , larger CNV magnitude was associated with improved accuracy.
Within neuropsychology , the term dispersion refers to the degree of variation in performance between different cognitive domains for an individual.
Within @number@ months following the onset of incontinence , @number@ patients completed questionnaires at @number@ occasions.
Within @number@ to @number@ milliseconds after stimulus onset , repeated stimuli elicited more positive amplitudes in younger participants , indicating stimilus recognition.
Within @number@ year from surgery , @percent@ of patients returned to practice and @percent@ returned to course play.
Within one week post intervention , @percent@ had made safety changes and @percent@ were \ "thinking about / intending \ " to make changes.
Within-pair analyses in twins discordant for PTSD produced consistent findings.
Within-pair estimates were similar , suggesting little or no familial confounding.
Within-person associations indicated that participants reported higher positivity on occasions when they were more socially active.
Within-person variability in behavior was assessed by reaction time ( RT ) variability.
Within-person , when participants exhibited lower cognitive performance , they also reported more IADL impairment.
Within-rater reliability was found to be very good ( r = @number@ ) .
Within semantic variant primary progressive aphasia the right-handed and non-right-handed cohorts appeared homogeneous on imaging , cognitive profile , and structural analysis of brain symmetry.
Within specific domains of SB , older adults report @number@ hr in leisure sitting time and @number@ hr watching TV.
Within-subject comparisons revealed that both control and PD participants benefitted from the provision of a directed , deep relational encoding strategy.
Within-subject comparisons were generated.
Within-subject distances were smaller than between-subject distances and ICC values ranged from @number@ to @number@
Within subjects , the extent of NR2B proteolysis was strongly correlated with the generation of ΔCN-Aα48 in the cytosol.
With insulin resistance-associated conditions reaching epidemic proportions , the prevalence of Alzheimer's disease and other cognitive disorders will continue to rise exponentially.
Within the 15th IHIWS new populations were included in the analysis.
Within the AD group , frontal cortical CB1 immunoreactivity correlated with cognitive scores assessed within a year of death.
Within the aging population , there exists a subset of individuals termed masters athletes ( MA ) .
Within the AP group , this specific electrophysiological marker was predictive of absolute-hearing behavior and explained ∼30% of variance.
Within the bilingual group , neither language of testing nor degree of bilingualism was significantly associated with 3MS or verbal memory scores.
Within the brain , estrogen regulates glucose transport , aerobic glycolysis , and mitochondrial function to generate ATP.
Within the cell , several mechanisms exist to maintain homeostasis of the endoplasmic reticulum ( ER ) .
Within the CLBP group , step width and double limb support time are significantly correlated with stair ascent / descent times.
Within the CLSA Tracking cohort , main effects of age and language were observed for all cognitive measures except RAVLT delayed recall.
Within the cohorts studied here , polygenic architecture plays an important role in modifying AD risk beyond APOE.
Within the context of an aging population , this will impose significant individual and societal burden , making the development of prevention programs imperative.
Within the context of combating cognitive decline through behavioural interventions , physical activity is a promising approach.
Within the current study , fluid cognitive abilities reflected this phenomenon.
Within the developed method , ( @number@ ) Pu was exploited as chemical yield tracer for both Pu and Np isotopes.
Within the DMN components , patients showed higher connectivity in the anterior DMN , in particular in logopenic aphasia.
Within the elderly cohort , there was no significant difference in efficacy of biologics versus conventional systemics at any time point.
Within the elderly population , biologics may be a safer option than conventional systemic agents.
Within the frontal cortex , the brain region related to response inhibition was identified in the right inferior frontal gyrus.
Within the group of PD patients with LID , there was no significant correlation between CB1 availability and LID severity.
Within the HCs , TNF-α levels were associated with physical comorbidity and body mass index.
Within the ILI , older adults experienced greater improvements than younger adults ( p < @number@ ) .
Within the liver vasculature , adenosine triphosphate is converted into pyrophosphate , a major inhibitor of ectopic calcification.
Within the medical field , they often bridge gaps between many specialities increasingly required to provide modern medical care.
Within the Medicare population , nonunion patients were younger than patients who healed normally.
Within the model , increasing the trabecular spacing with a fixed trabecular radius is equivalent to thinning the trabeculae while maintaining constant spacing.
Within the next few decades , the number of older drivers operating a vehicle will increase rapidly ( Eurostat , @number@ ) .
Within the older adult group , higher frontal activation was associated with poorer behavioral performance under all task conditions.
Within the prevalent population , life satisfaction and community participation are greater among persons who are at least @number@ years postinjury.
Within the proposed \ "neurodegeneration paradigm \ " , observations have been put forth for \ "accelerated aging \ " in this disorder.
Within these themes , facilitators and barriers were identified.
Within the stromal vascular fraction of adipose tissue , macrophages and T cells accumulate with increasing tissue mass , secreting pro- or anti-inflammatory cytokines.
Within the subgroup of patients aged @number@ to @number@ years , it improved clinical outcome including the primary end point.
Within the substantia nigra high signal structures corresponded to confirmed nigrosomes.
Within the younger group ( 0-65 years ) there was an increase in numbers on HD and in the number of pre-emptive transplantations.
Within this age group , cardiovascular diseases ( CVD ) increase steeply and are the most common cause of death.
Within this age group ( @number@ years plus ) , the domestic garden frequently forms an intrinsic component of ongoing health and well-being.
Within this booming industry , several different types exist.
Within this cohort , there is much diversity in health , socioeconomic levels , education , and health beliefs.
Within this context , stem cells may provide a clinical approach for AKI.
Within this discourse ageing is presented as a risk , where loneliness is one of these risk factors.
Within this dynamic and changing environment , the ability to remain responsive to patient needs while managing these issues poses further challenges.
Within this group , a subgroup with an intensive intervention ( n = @number@ ) was performed.
Within this modular complex , Ataxin-7 anchors the deubiquitinase activity to the larger complex.
Within this network , differential recruitment of specific areas highlights the episodic distinction between past and future mental time travel.
Within this percentage the levels of β-carotene were significantly lower when body mass index increased.
Within this platform , the web-based decision aid component performed comparably with the videobooklet decision aid used in clinical practice.
Within this same study we found a @number@ to @percent@ increase in ROS production in old rats compared to young rats.
Within this sample of cognitively intact oldest old , measures of executive control and cognitive functioning demonstrated limited association with mental health.
Within this scenario , the purpose of the present work was to understand if immune status is associated with survival and health status in centenarians.
Within this selection , @number@ articles were categorized as original research ( gencho ronbun ) .
Within this study period , @number@ ( @percent@ ) elders died and @number@ ( @percent@ ) survived.
Within this therapeutic window , antimuscarinics may decrease OAB symptoms and DO without affecting the voiding contraction.
Within this work , we also discuss potential future research directions in this area.
Within virtually every surgical specialty , studies have shown that patients should not be denied surgery on the basis of chronological age alone.
Within-woman PMD declined during these ages , with a slowing rate of decline.
Within-woman rank correlation of PMD was @number@ for readings taken @number@ years apart.
Within younger adults , greater MPFC-DLPFC anticorrelation at rest correlated with greater WM capacity.
With knock-down of Nrf2 or NQO1 , DMF failed to prevent TNF-α-induced cell apoptosis and decreased eNOS expression.
With laser toning being frequently performed , this complication may become more commonly encountered in clinical practice.
With latent class analysis , two classes of older adults were identified.
With longer life expectancy , the number of burn injuries in the elderly continues to increase.
With long presentation times , task load modulated the CDA in children and older adults but not in younger adults.
With low-dose phorbol 12-myristate 13-acetate ( PMA ) or anti-IgM treatment , TGF-β sensitivity was restored by stabilizing TβRII expression and sustaining TGF-β signaling.
With many IAD patients developing intracranial hemorrhage , antithrombotic therapy should be used with caution.
With medical advances , more individuals with cerebral palsy ( CP ) syndromes who reside in developed countries are surviving to adolescence and adulthood.
With minor differences , the aetiological profile in our biopsied neuropathic elderly subjects may reflect the findings in other similar cohorts.
With modern medicine and an awareness of healthy lifestyle practices , people are living longer and generally healthier lives than their ancestors.
With multiple treatments over time , collagen , elastic tissue , and mucin is produced resulting in improvement of acne scars and photo-damaged skin.
With natural aging and exacerbated by numerous pathological conditions , bone removal exceeds bone formation , disrupting homeostasis and resulting in bone loss.
With NKAP-specific antibodies we found that NKAP localizes to nuclear speckles.
With no lower or upper age limit , only those diagnosed with PD since at least one year were included.
With nonsurgical procedures , there have been new developments in achieving more significant aesthetic improvements with less downtime and less invasively.
With normal aging , photoreceptors are steadily lost , Bruch's membrane thickens , the choroid thins , and hard drusen may form in the periphery.
With @number@ years of follow-up , mean YoL was @number@ YHL , @number@ and YAL , @number@
With objects , the critical spacing of crowding for AMD participants was not substantially different from controls.
With older women having the greatest need for health care , an age- and gender-sensitive approach is recommended.
With only symptomatic treatment available , efforts to develop new therapeutics aimed at lowering the amount of Aβ peptides in the affected brain have intensified.
With only two cases of IA due to azole-resistant A. fumigatus , a change of antifungal treatment practices in Germany does not appear warranted currently.
With or without adjustments , outcomes were all significantly better in the normal than complex infarct cluster.
With our country going into the aging society , burns in the elderly often occur.
Without an appropriate posture control response when experiencing an unexpected external perturbation , fall may occur.
Without EDC treatment , the reduction in tanδ of the hybrid layer prepared with SB exceeded @percent@ in @number@ months.
Without effective strategies to counteract aging muscle loss , a global health care crisis may be inevitable.
Without intervention , these effects contribute to age-related systemic metabolic dysfunction , physical limitations , and frailty.
Without lung infiltrates on CT , IPA is ruled out.
Without missing a single case , this model identified @number@ patients ( @percent@ ) without advanced fibrosis in the validation set.
Without promoting the availability of assistive products the SDGs cannot be achieved equitably.
Without respect to age , head injury increased the odds of mortality ( OR = @number@ ) .
Without screening , clinical staff identified only a small proportion of malnourished patients ( @percent@ of MN and @percent@ of AR ) .
Without sound principles , the neck appears skeletonized , tethered , and hollow.
Without these improvements , the ability to deliver high-quality specialist palliative care to patients with HF and their families will remain severely limited.
With overhead , program cost totaled $ 696 per participant.
With people aging , osteoporosis is expected to increase notably.
With @percent@ elderly proportion , the estimated volume of health services via conventional medical care system is @number@ × 10⁸.
With pictures , however , the age-related decrement was eliminated and context effects were reduced.
With population aging now a global phenomenon , the health of older adults is becoming an increasingly important issue.
With potential for pharmacological intervention to exacerbate behaviors or even lead to mortality , the development and rigorous testing of non-pharmacological interventions is vital.
With practice , pairs ( e.g. , IVY-BIRD ) in a lookup table can be verified by memory rather than by visual search.
With professional transcribed tapes from the focus group discussions , we used a systematic text analysis approach.
With QTIP , we specifically enrich telomeric DNA and all shelterin components.
With rapid population aging , increasing attention is given to the mental health of older people.
With recent advancements in medical care , a number of options have emerged as alternatives to conservative systemic analgesia.
With regarding to metacognitive monitoring , we found age-equivalence for identity prediction accuracy and an age-related deficit in prediction accuracy for location information.
With regards to CKD , lithium can be used safely in many older adults with mood disorders.
With regards to DTI parameters , there were more regions of significant differences in FA among these three subgroups compared with MD.
With regard to biomarkers , CAC was significantly associated ( negatively ) to G-CSF and IL-13.
With regard to both individual ( personal ) and collective ( societal ) spheres , negative images of old age dominate public debate.
With regard to false recollection , older adults exhibited significantly greater false recollection yet did not exhibit increased neural processing.
With regard to functional connectivity , both higher and lower functional coupling has been observed in the aging compared to the young brain.
With regard to healthy aging , previous studies mostly measured motion coherence thresholds for coarse motion direction discrimination along cardinal axes of motion.
With regard to ICTs , participants perceived a digital divide.
With regard to most diagnostic accuracy parameters , SMMSE scores did not outperform the MMSE scores.
With regard to multimorbidity distribution , women over @number@ years suffered from the highest rate of multimorbidity ( @percent@ ) .
With regard to oral cavity , it is known that jaw bone morphology greatly changes with tooth loss.
With regard to potential conflicts of interest , there is nothing further to disclose.
With regard to prioritisation of fragility fracture prevention in national policy , there is much to be done.
With regard to quantity of alcohol and type of alcohol , all hazard ratios were found to be lower than @number@
With regard to retirement-related issues , @percent@ reported concerns about adequate financial preparations and @percent@ reported concerns regarding loss of identity upon retirement.
With regard to strategies employers might use to increase hiring and retention , respondents identified increased training and centralized disability and accommodation expertise and mechanisms.
With regard to strength , functional performance and well-being , no time-by-group interaction effects were found.
With regard to systemic parameters , systolic blood pressure and heart rate were positively correlated with IOP ( P < 0.001 ) .
With regard to the agar diffusion test , the inhibition zone of the quinone compounds was threefold larger than that of oxacillin.
With rehabilitation , patients improved the values of strength , power , and the results of all functional tests.
With relation to the quality of attachment , anxiety in close relations appears to diminish as people age , while attachment avoidance remains relatively stable.
With repeated low-dose UV-A1 irradiation , skin darkened incrementally with each exposure.
With respect to drug-drug interactions , most criteria agreed that concomitant use of warfarin and NSAIDs should be avoided.
With respect to eating , increasing estrogen levels progressively decrease eating during the follicular and peri-ovulatory phases of the menstrual cycle.
With respect to eversion and inversion , WBVG and MTG improved strength at 60° / s.
With respect to Frost's early delineation of micropetrosis , our microanalyses revealed that the osteocyte lacunae are subject to hypermineralization.
With respect to OTA-producing fungi , a low percentage of fungal strains ( @percent@ ) were able to produce OTA at moderate levels.
With respect to PA , no time-to-death-related effects were discovered , but linear age-related decline was found.
With respect to specific cognitive tests , AD produced lower scores on list learning tests , category fluency , and the Digit Symbol substitution test.
With respect to their degradation , filler materials may be classified as temporary ( degradable ) , semi-permanent and permanent ( not degradable ) .
With respect to the localization of colorectal cancer a shift to the right has been observed with increasing patient age.
With RT-PCR assays , an increase in mRNA for collagen type I , type III and MMP-1 were observed.
With screening and intervention , many falls can be prevented.
With self-paced encoding , older adults were also capable of binding at least three units during encoding.
With seven CCA diameters , the amounts of disturbed flow agreed unambiguously with those predicted by the corresponding full-length models.
With short presentation times , task load increased CDA amplitude and decreased behavioral performance in younger adults.
With significant implications in health , disease and ageing , the latter appears poised to revolutionize biology.
With Singapore possessing an advanced aging population , its policy provides a useful case study of eldercare to cater to evolving population demographics.
With socio-economical and demographical changes , families need to be supported when taking on the caregiving role and be offered alternatives of care.
With standard dextrose-based saline solutions infused at fluid maintenance rate , only approximately @percent@ or less of EGP is provided.
With Student's t test , significant gender differences in the average contents of Ca and P were found in both the 40s and the 70s.
With successive stages , physical and cognitive capacity decreased and symptoms and multimorbidity increased.
With successive steps , 20-25 yo demonstrated a progressive decrease in SL variability , but SL variability of the two older groups did not change.
With such a framework , the brain can be depicted as a set of nodes connected by edges.
With such misconceptions , cellular senescence cannot be linked to organismal aging.
With technological advances it is now possible to objectively measure the everyday driving of older adults in their own vehicles over time.
With technological innovation , comprehensive dietary intake data can be collected in a wide range of studies and settings.
With telomerase repressed , we then see the evolution of replicative aging.
With the advancing age of our population , understanding how use-dependent plasticity changes across the lifespan may also help to promote healthy brain aging.
With the advent of aging , the morbidity rates of such diseases as osteoarthritis , rheumatoid arthritis , and osteoporosis has witnessed a significant increase.
With the advent of miro-liposuction techniques , there is renewed interest in the use of aspirated fat.
With the advent of regenerative medicine , extensive studies aimed to repair , regenerate or replace lost hair cells have been initiated.
With the aging case management workforce , bringing up younger professionals is a vitally current issue.
With the aging of @number@ million baby boomers , dental caries will continue to pose a significant challenge for older adults.
With the aging of populations , new un-faced challenges are brought to science.
With the aging of the population and longer life expectancies , the prevalence of population with multiple chronic medical conditions has increased.
With the aging of the population and the development of imaging technology , the morbidity and diagnostic rates of WMLs are increasing annually.
With the aging of the population , low bone mass states will be an increasing clinical issue for both men and women.
With the aging of the population , the call for modifiable factors is emerging.
With the aging of the population , the incidence and prevalence of HF is projected to increase.
With the aging of the population , the interest in clinical trials concerning frail elderly patients has increased.
With the aging of the population , this matter will become of even greater importance.
With the aging of the population worldwide , osteoporosis and osteoporotic fractures are becoming a serious health care issue in the Western world.
With the aging of the renal-transplant population , the diagnosis and management of prostate cancer in these patients needs further evaluation.
With the aging of the US population , this trend is expected to continue.
With the aging of the workforce , the incidence is expected to increase further.
With the aging of the world's population there has become a major need for the development of nursing homes throughout the world.
With the aging of this population , new clinical manifestations are expected , requiring close and continued MFS patient monitoring.
With the aging population and increasing comorbidity , these findings have important health policy implications for the care of critically ill patients.
With the aging population and rising incidence of primary total joint arthroplasty has come the increasing incidence of revision total hip arthroplasties.
With the aging population in China , both incidence and mortality of prostate cancer are expected to keep increasing in the future.
With the aging population in Europe it is anticipated that the growing demand for blood products will not be met by the estimated supply.
With the aging population in Japan , prescriptions for donepezil are increasing.
With the aging population in the Western hemisphere , neurodegenerative parkinsonism and dementia will become two of the great public health challenges of this century.
With the aging population , significant valvular heart disease is increasingly identified in patients too frail to undergo surgery.
With the aging population , the incidence of chronic subdural hematoma ( CSDH ) is expected to rise.
With the aging population , the number of persons using a hearing aid is increasing.
With the aging US population , demographic shifts , and obesity epidemic , there is potential for further exacerbation of the current liver donor shortage.
With the aid of a manual , the training adopted a learner-oriented approach that directly encouraged learners to generalize strategic behavior to new tasks.
With the aim of optimizing patient comfort and control over administration of NASHA-based gel , the panel members explored an alternative , sharp-needle technique.
With the application of IDS , no significant difference was noted between L and MR materials ( p = 0.160 ) .
With the availability of newer imaging techniques , specifically HRpQCT and microCT-3D , micro-architectural differences related to sex-differences have been studied.
With the average life expectancy continuing to climb , understanding patterns of morbidity in aging populations has become progressively more important.
With the coexistence with impaired antioxidant defence , all these issues lead to oxidative and carbonyl stress.
With the complex task , an external focus resulted in faster times in retention than an internal focus , but only for males.
With the current demographic shift being experienced by populations globally , almost linear increases in life expectancy have been seen and can be expected.
With the customized atlas-based analysis , the fractional anisotropy ( FA ) detected closely approximated the manual measurements.
With the deferment of marriage and childbearing , couples are turning to assisted reproductive technology to counteract this decline.
With the degree of degenerative changes , the expression of MMP-1 and TIMP-1 increased obviously.
With the development of gene technology , the effect of genetic factors on the pathogenesis of WMLs is gaining gradual attention.
With the development of genetically engineered animals , essential molecules for skin-wound healing have been identified.
With the development of living standard and the aging society , the incidences of metabolic syndrome and benign prostatic hyperplasia are getting higher and higher.
With the diagnosis of multiple sclerosis , corticosteroid therapy resulted in rapid improvement of his symptoms and MRI abnormalities.
With the discovery that cardiac stem cells reside in the heart comes the question whether these cells are also impaired upon aging.
With the emergence of experimental therapeutics targeting CD47 , a more thorough understanding of CD47 signal transduction is essential.
With the emergence of molecular methods , newer respiratory viruses are being detected.
With the exception of Filtek Supreme , there were significant reductions in fluorescence intensity for all the tested composites ( P < @number@ ) .
With the exception of interleukin-6 in the dermal tissue , no upregulation was detected in the aged group.
With the exception of microinfarcts and arteriolar sclerosis , all neuropathologies were associated with the cognitive trajectory.
With the exception of several items on perceived activation demands , paid work and volunteering were not significant longitudinal predictors of such demands.
With the exception of strength and CK , signs and symptoms of CIMD were independent of menstrual cycle phase.
With the exception of the 85 + age group , we found greater intra-group variability with advancing age.
With the exception of the 9-year age group , no significant differences between the genders were found.
With the exception of WHR , in men , sf-H was positively and independently associated with other indicators.
With the expanding use of engineered nanoparticles ( NPs ) , development of a high-throughput , sensitive method for evaluating NP safety is important.
With the global rise in aging of populations , the occurrence of osteoporosis will continue to increase.
With the growing population of older adults in the United States , effective and scalable public health approaches are needed to address this problem.
With the growing population of older adults , nurses will need to address age-related cognitive declines.
With the growth of aging society , China has become the country of population with the highest incidence of diabetes in the world.
With the help of gerontechnologies , safe home environment and monitoring of health state can be ensured.
With the Hi-square test , it was determined that there are differences between the groups.
With the increased age range in the age-memory data set , the correlation between hypergraph cardinality and age correspondence becomes significant.
With the increased aging of society , the demand for the prevention and treatment of locomotive syndrome to improve healthy life expectancy is increasing.
With the increase in age , older adults are likely to have elevated blood glucose level.
With the increase in the number of old people , a parallel increase in the number of the disabled elderly is postulated.
With the increase of FRS , the GFR and Ccr decrease.
With the increase of SUA levels , the prevalence of MCI showed a strong decreasing linear trend.
With the increasing aging population these numbers are projected to continue to increase.
With the increasing number of older drivers , road traffic safety is an urgent public health issue.
With the increasing of governments ' subsidies , the proportion of individual's premiums should also be increased.
With the introduction of highly active antiretroviral therapy ( HAART ) , HIV has become a chronic disease.
With their 24 / 7 availability , poison centers appear to be an increasingly important resource for patients experiencing unintentional therapeutic errors involving insulin.
With their fine processes microglia are continuously scanning their environment.
With their unique knowledge of complex chronic disease management , experts in geriatrics are positioned to help address the aging crisis in correctional health care.
With the laser-based optical cell stretcher we examined the viscoelastic biomechanics of dermal fibroblasts isolated from @number@ human donors aged @number@ to @number@
With the left eye occluded , subjects were instructed to look quickly toward any seen stimuli.
With the Netherlands facing a rapidly ageing population , such statements are well-received by policy makers.
With the number of older adults increasing , creating research protocols that include older adults with multiple chronic comorbidities is imperative.
With the ongoing ageing of western societies , the proportion of older breast cancer patients will increase.
With the physical functioning outcome , there were independent protective effects from volume and intensity of physical activity.
With the population aging , a large number of patients undergoing rehabilitation are older than @number@ years.
With the population and proportion of the elderly increasing each year , difficulties with postoperative treatment outcomes after osteoporotic hip fracture are increasing.
With the population projected to increase @date@ @percent@ by @number@ expected general practice utilisation will increase by @date@ @percent@.
With the possible exception of the zygomatic-cutaneous ligament , they are only carefully distended.
With the prevalence of obesity , artificial , non-nutritive sweeteners have been widely used as dietary supplements that provide sweet taste without excessive caloric load.
With the rapid aging of the oldest old , it is inevitable that nurse practitioners will encounter frail patients across care settings.
With the rapid aging of the population , Korea introduced public long-term care insurance for older people in @number@
With the rapid aging of the world population , the issue of skeletal health is becoming more prominent and urgent.
With the rapid development of global population movements , family practices need to pay attention to the changes of family support among migrant families.
With the rapidly aging population in the country , the prevalence of HF and its associated costs are expected to rise continuously.
With the rapidly aging population , it is expected that increases in cases of dementia will double over the next @number@ years.
With the rate of aging rising each year , the number of patients with dementia increases.
With the reported technique , the authors achieved pleasing , natural , durable results with minimal morbidity and an overall complication rate of @percent@.
With the results of this study , the assessments of verbal reaction time may helpful for diagnosis of early AD.
With the rise of aging population , clinical concern and research attention has shifted towards neuroimaging of dementia.
With the rise of aging populations , new challenges for health care systems are emerging.
With these changes have come an increased prevalence of age-related pathologies and health burdens in the elderly.
With these demands , it is now critical to understand the fundamental regulatory mechanism for aging and longevity in mammals.
With these developments and medical support , the number of operations on very elderly patients has been increasing.
With these findings , we could identify the imaging tests that best detected stenosis.
With these issues in mind , we believe that the primary prevention modality in coming decades will be pharmacological.
With these markers we identified a large subgroup in the general population with a substantially increased risk of TPOAbs.
With these multiple changes it is difficult to precisely classify an individual's response in sepsis as proinflammatory or immunosuppressed.
With these new data come technical challenges , but also new possibilities.
With the serial transplantation , the 30-day survival rate and the hematology in peripheral blood of recipient mice decreased.
With the shifting age demographics of the U.S. population , more psychologists will be asked to provide clinical services to older adults.
With the speeding tendency of aging society , human neurological disorders have posed an ever increasing threat to public health care.
With the traditional definition , inter-rater reliability between the four raters was moderate ( ICC = 0.667 , p < 0.001 ) .
With the use of a multiple linear regression model , a cluster of variables was identified that significantly related to weight gain.
With the use of different physiologic or pharmacologic stimuli , endothelium-dependent ( micro ) vascular reactivity can be studied.
With this approach , we found a surprisingly high frequency of heteroplasmic mtDNA variants in @percent@ of subjects.
With this as its major objective , the ComNet project has recruited almost @number@ research groups willing to share datasets.
With this background , it becomes increasingly challenging to select the right treatment strategy for each patient.
With this confirmation that an association exists , clarification of underlying etiologic pathways requires urgent attention.
With this data , we created a homologous model consisting of @number@ data points for each face based on @number@ anatomical landmarks.
With this design we have identified @number@ regions that are significantly and consistently hypomethylated with age and @number@ regions that are significantly hypermethylated with age.
With this in mind , researchers have begun to examine the effects of ageing on decision making and associated neural circuits.
With this method , we obtained up to @percent@ pure non-CF and CF-PAEC.
With this model , we simulated @number@ years of influenza transmission and compared influenza transmission rates in populations with and without the one-child policy control.
With this paradigm , the authors determined age-relevance ( How typical is a characteristic for a given age decade ? ) .
With this rapidly growing vulnerable population , it becomes imperative to identify enhanced and novel preparedness strategies and measures.
With this review , we aim to investigate whether microfluidics can become widely applied in regenerative medicine research and / or strategies.
With this screening approach , we also identified a second senolytic agent called piperlongumine ( PL ) .
With this understanding , drugs need to be more precisely directed at specific brain targets.
With thorough validation , quantification of inherited genetic variation may prove useful for stratifying AD risk and as an enrichment strategy in therapeutic trials.
With use of a simple and quickly performed test like the MMSE patients can be effectively screened for impaired cognitive function.
With very simple easy-to-reproduce tests , cohesivity and resistance to traction forces were examined.
With vulvovaginal candidiasis , differentiating between Candida albicans and non-albicans Candida infection has important treatment ramifications.
With well-established toxicity and neurogenetic assays , it is now feasible to explore the putative link between metal- and chemical-induced neurodegeneration.
With whole cell patch-clamp techniques , action potentials and slowly activating delayed rectifier potassium currents were recorded in isolated guinea pig ventricular myocytes , respectively.
With worldwide expansion of the aging population , research on age-related pathologies is receiving growing interest.
Witnessed apnoea was more common in males and in those with hypothyroidism than in females and in those without hypothyroidism.
Wives also reported greater decreases in depressive symptoms after placement in an institution when compared with husbands.
Wives booked @time@ % of the consultations.
Wives emerge as the most vulnerable of the four groups when both burden and self-esteem are considered.
Wives were sources of nutrition information and social support.
WLR correlated inversely with AVR.
WLR correlated significantly with age ( r = @number@ p < @number@ ) .
WLR correlated significantly with the stage of microvascular abnormalities.
WLR was calculated by the formula [ Formula : see text ] .
W ( max ) was improved only in SE3.
WM ( but not vigilance ) ability was a strong predictor of irregular PM tasks with less focal cues.
WM capacity may serve as a cognitive reserve associated with sentence-comprehension abilities for elderly adults.
WMH and FA significantly mediated the pain-gait speed relationship.
WMH and gray matter were automatically segmented , and the total WMH and gray matter volumes were measured.
WMH burden was not associated with motor function in persons with high activity ( 90th percentile ) .
WMH in the frontal-parietal and in the network were associated with decline in executive functioning.
WMH in the older population may be small , diffuse , and irregular in shape , and sufficiently heterogeneous within and across subjects.
WMH progression rate was measured by subtracting WMH volume at baseline from that at the follow-up using volumetric analysis , divided by the MRI intervals.
WMH progression was measured on MRI over @number@ years in @number@ older adults , in a same-year-of-birth cohort.
WMHs could be a reliable biological risk marker for late onset mood disorders.
WMHs on magnetic resonance images were assessed using manual visual rating and automatic volumetric segmentation.
WMHv and age were strongly correlated ( ρ = .57 , P < .0001 ) .
WMH volumes were quantified using an automated method.
WMH volumes were significantly associated with neuropsychological tests and dual task CSRT performance.
WMH volume was expressed as percent of intracranial volume.
WMH volume was quantified algorithmically.
WMHV was studied both in a continuous and dichotomous manner , the latter reflecting the age-specific top quartile of WMHV ( EXT-WMHV ) .
WMH were also associated with slowed search times independent of processing speed differences.
WMH were also found more frequently among the DM individuals.
WM injury was categorised as normal / mildly , moderately and severely abnormal.
WM integrity differences in DS compared with CTL were found predominantly in the frontal lobes.
WML and NAWM PiB signals were then extracted.
WML are an active pathology with a complex pathogenesis that may potentially offer a number of primary and secondary intervention targets.
WML did not explain the association between plasma Hcy level and navigation performance.
WML masks from @number@ cognitively normal ( age @number@ ± @number@ years , @percent@ women ) individuals were obtained from T2-FLAIR.
WMLs are not a benign process.
WML severity was assessed in the postmortem brain donations using magnetic resonance imaging ( MRI ) scans and scored using the Scheltens ' scale.
WMLs may be age-related degenerative change , but few studies have addressed the relationship between vascular aging and WMLs.
WMLs were not associated with increased odds of dementia in those with the largest TICV.
WML volumes and their progression were estimated with the use of a fully automatic procedure.
WML volume was associated with significant decline in z score of executive functioning.
WML were associated in SCI with total episodic EEG abnormalities ( p = 0.03 ) .
WML were segmented manually.
WM malfunction can induce serious neurobehavioral and cognitive impairments.
WM networks were reconstructed from DTI using tractography and graph theory.
WM performance was associated with microstructure in left fronto-parietal pathways and LTM was associated with bilateral fronto-temporal pathways.
WM performance was lower in older adults and children than in younger adults.
WM tracts abnormalities were limited to increased axial diffusivity in the right cingulum , superior longitudinal fasciculus , and corticospinal tract.
WM Training activities were based on Baddeley's model ; Poetry-based Stimulation Program was composed by general language activities.
Wnt signaling has emerged in recent years as a major player in both nervous system development and adult synaptic plasticity.
Wnt signaling induces osteoblast differentiation and activates glycolysis through mammalian target of rapamycin , whereas parathyroid hormone stimulates glycolysis through induction of insulin-like growth factor-I.
Wnt signaling is a highly conserved pathway that participates in multiple aspects of cellular function during development and in adults.
Wnt / β-catenin inhibition with Dkk-1 prevented the P-induced down-regulation of Klotho.
WNT / β-catenin pathway and PPARγ act in an opposite manner in several diseases.
Woman's sexuality encompasses sexual identity , sexual function , and sexual relationships.
Women ≥65 years were included ( n = @number@ @date@ to @date@ ) at the time of admission to a nursing home.
Women across all ages had lower group mean EPTs than men ( P < @number@ ) .
Women aged 65-74 years are observed more time to make decisions and stereotyped of behavior compared to women aged 55-64 years.
Women aged @number@ years and over ( @number@ ) randomly sampled from Primary Healthcare Services around Spain were included.
Women aged @number@ years and over with a new episode of acute LBP were included.
Women aged @number@ years were expected to live @percent@ of their remaining lives-twice the percentage for men-with at least one ADL disability.
Women also had smaller subcortical structures.
Women also reported more intense pain compared to men-2.13 versus @number@ respectively ( p < @number@ ) .
Women also reported slightly higher anxiety and avoidance compared to men , especially in young adulthood.
Women and blacks are critically understudied populations that carry a sizeable portion of the heart failure burden.
Women and caregivers were significantly less likely to agree that their hypothetically afflicted relative should be informed of a diagnosis of AD.
Women and female great apes both continue giving birth into their forties , but not beyond.
Women and illiterate individuals have a higher prevalence.
Women and men improved race times across years in all age groups.
Women and men with low spine vBMD have greater severity of vascular calcification , particularly at the abdominal aorta.
Women and older men are more interested in health safety and are more responsible for their health.
Women and subjects with diabetes had greater CH and CRF.
Women appear immune-privileged.
Women are inundated with advertisements for products promising younger-looking , healthier skin.
Women are living longer with HIV infection , but their life expectancy remains shorter than for women in the general population.
Women are treated less frequently with intravenous thrombolysis compared with men stroke patients and the two genders seem to respond differently to aspirin and statins.
Women are underrepresented in most clinical trials and only a minority of drug applications to regulatory authorities have included sex analyses.
Women at high risk for menopausal diseases should be advised on HRT.
Women at least @number@ years of age who reported symptoms of VVA and residing in the United States were recruited.
Women caregivers in @number@ were less likely to be working in @number@ whereas employment status was not related to subsequent caregiving.
Women changed their specialty and / or place of work more often than men.
Women colorectal tumors contained more NUMT than men.
Women continue to be more likely to practice in academic centers , be pediatric cardiologists , and have a noninvasive subspecialty.
Women currently are limiting the number of children they bear and their life expectancies may be longer than predicted by evolutionary design.
Women demonstrated higher expression of GATA-3 in compare with men.
Women described how the services of an oncology nurse navigator facilitated their progress.
Women , ethnic minorities , and those who were not partnered were also more likely to be frail.
Women exposed to intimate partner violence ( IPV ) experience chronic stress and report worse health.
Women form a growing minority within the worldwide prison population and have special needs and distinct characteristics.
Women from all three ethnicities described an attitude of acceptance surrounding menopause and the changes associated with it.
Women from the general community , including multiple sites in the United States , were enrolled between @number@ and @number@
Women generally have a reduced risk of cardiovascular disease ( CVD ) .
Women generally lack sufficient knowledge regarding their pelvic-health needs and feel embarrassed to seek pelvic-health-related medical advice.
Women generally spend the last third of their lifetime in menopause , after their reproductive years have ended.
Women had a higher LV EF than men when using QGS methods , but not when using the 4D-MSPECT method.
Women had a @percent@ lower 5-HT ( @number@ ) receptor binding in the limbic system.
Women had a sharper decline in frequencies of self-reported physical activity.
Women had better knowledge than men.
Women had fewer anxiety symptoms at the oldest ages.
Women had fewer salty-bitter confusions than did men ( @percent@ vs. @percent@ ) .
Women had greater EF ( @number@ ± @number@ versus @number@ ± @percent@ ; P = @number@ ) .
Women had greater mean CSF F2-IsoP concentrations than men at all ages after adjusting for other factors ( P = @number@ ) .
Women had higher ECV than men but less ECV change over time.
Women had higher EPTs as they advanced in age , but this was less clear in men.
Women had higher levels of IL-6.
Women had higher plasma levels of all sphingomyelin species and showed steeper trajectories of age-related increases compared to men.
Women had higher rates of cataract , which was not explained by differential access to surgery.
Women had higher values of MHR , regardless of the age group.
Women had longer LTL than men ( p < 0.0001 ) .
Women had median ( with interquartile range ) AFC of @number@ ( @number@ @number@ ) .
Women had more daily 1 + minute sedentary bouts than men ( @number@ vs. @number@ ) , indicating they break up sedentary time more often.
Women had more negative perceptions about aging ( e.g. , feelings of powerlessness ) and more sleep complaints than men.
Women had @percent@ higher odds of receiving a NOAC in AF.
Women have each disability and at least one disability in significantly higher percentages than men.
Women have higher caudate nucleus dopamine transporter binding compared with men in both normal and degenerated dopamine systems.
Women have higher rates of healthcare utilization , as shown by significantly higher rates of hospitalization and outpatient encounters.
Women have lower stroke incidence than men until an advanced age , when the epidemiology of ischemic stroke shifts and incidence rises dramatically in women.
Women have poorer functional outcomes , are more likely to need nursing home care and have higher rates of recurrent stroke compared with men.
Women in both cities were more likely to be restricted to their neighborhood and had lower LSA scores.
Women , individuals aged @number@ to @number@ and individuals with physical frailty or depression had higher rates of restricting fatigue than their respective counterparts.
Women infected with human immunodeficiency virus ( HIV ) have unique needs.
Women in midlife also reported more vivid memories.
Women in the fastest growing demographic , the oldest old , should be screened for cognitive disorders , especially high-risk groups.
Women in the highest tertile of FTI demonstrated greater anterior lead JPA compared with the lowest tertile ( p < 0.05 ) .
Women in the late menopausal transition and early menopause are least responsive to pelvic floor muscle strength training.
Women in the LOD groups had extensive cortical thinning in the lateral prefrontal cortex bilaterally compared with EOD women.
Women in the lowest quartile for mesor performed worse on categorical fluency ( d = @number@ words , P < @number@ ) .
Women in the lowest tertile of the MyPyramid milk group had the highest uNTx / Cr.
Women in the PI cohort used MI medical services @number@ months earlier than PI males ( p = 0.0059 ) .
Women in the United States have a @percent@ lifetime risk of undergoing surgery for POP ( ) .
Women in the United States have a @percent@ lifetime risk of undergoing surgery for POP ( @number@ ) .
Women in the United States have a @percent@ lifetime risk of undergoing surgery for POP ( @number@ ) .
Women in the United States have a @percent@ lifetime risk of undergoing surgery for POP ( @number@ ) .
Women knew more about ED than about POP , a condition that may affect them during their lifetime.
Women lived longer than men in any studied categories ( p < @number@ ) .
Women live longer than men.
Women managers in public organizations , who had less seniority and less previous experience with working-carers , tended to be more positive about supportive policies.
Women may also be particularly vulnerable to the vascular effects of elevated uric acid.
Women meeting the recommended Mg intake were at a @number@ % decreased risk for future fractures.
Women never smokers exhibited significantly better scores than past and / or current smokers in some neurocognitive tests.
Women ( n = @number@ ) were on average @number@ ± @number@ years old , and men @number@ ± @number@ years old.
Women of different somatotypes vary significantly in height and weight and other anthropometric parameters.
Women opting for IVF should be counselled about age-specific success rates while taking into account individual risk factors.
Women outperformed men for female faces , exhibiting a sex difference and own-sex bias.
Women outperformed men on all memory tasks ; men outperformed women on two non-verbal measures.
Women outperform men on verbal and men generally outperform women on visuospatial memory tasks.
Women participated in 90-minute twice-weekly exercise regimens.
Women , people of English-speaking origin , and those having contact with a person with dementia , showed better knowledge of several health behaviours.
Women ( P = @number@ ) and current smokers ( P < @number@ ) were at increased risk of neovascular AMD.
Women positive for cytology [ atypical squamous cells of undetermined significance ( ASC-US ) or worse ] or hrHPV were referred for colposcopy.
Women presented compression fractures associated with thoracolumbar transition , while men presented with listhesis associated with cervical lesions and increased complications.
Women produce higher normalized GRF ( p = .031 ) during the double support phase.
Women provided information on health an average of @number@ years later.
Women randomized to CaD had a @number@.46-mg / dL mean decrease in LDL-C ( P = @number@ ) .
Women reach their highest level earlier than men , consistent with their more precocious biological development.
Women received intravenous ⁴²Ca with the first test meal.
Women regardless of age group had significantly higher thresholds than men on both tasks.
Women remember more female than male faces , whereas men do not seem to display an own-gender bias in face recognition memory.
Women reported better health than men.
Women reported higher levels of anxiety and fear about driving than men , but there were no age differences.
Women reported higher levels of stress than men.
Women reported shorter sleep than men from age @number@ to @number@ but slept longer than men by age @number@
Women retain this advantage in aMCI despite reduced hippocampal volume and temporal lobe glucose metabolism.
Women self-reported demographics , health habits , and chronic conditions , and self-rated their health.
Women's fertility steeply decreases with increasing age , but the intensity of the decrease is individually significantly variable.
Women showed a correlation with higher MHR ( p < 0.001 ) .
Women showed a higher probability of cognitive impairment than men.
Women showed higher prevalence of disability ( ADL , IADL , and mobility ) as compared with men in all surveys.
Women showed higher vitamin C plasma concentrations than men ( @number@ @date@ μmol / l , P < 0·0001 ) .
Women showed lower PEmax.
Women show higher vitamin C plasma concentrations than men , but the reasons for this observation still require elucidation.
Women's loneliness was related to economic problems in their childhood family.
Women's motives for committing suicide differed partially from those of men.
Women's recommendations to facilitate successful recruitment included giving incentives to participants , and employing a recruiter who was trustworthy , informed , and culturally sensitive.
Women's Rsp and Zsp values tended to drop , attributable to their declining proportion of fat mass.
Women underestimate the role of cardiovascular diseases as causes of mortality , yet little information is available about their subjective risk awareness.
Women used more drugs than men at all waves.
Women were administered a comprehensive neuropsychological battery and assessed with the Center for Epidemiologic Studies Depression Scale.
Women were allocated into early ( the first @number@ years after menopause ) and late ( after the first @number@ years ) stages.
Women were asked about @number@ basic ADLs.
Women were categorized into @number@ ) no current use and @number@ ) current use of multivitamins.
Women were classified by Cr levels > 1 mg / dL or eGFR < @number@ ml / min.
Women were de facto caregivers but the traditional role of female relative as caregiver was beginning to be contested.
Women were enrolled between @number@ and @number@ data collection for these analyses continued through @number@
Women were followed for an average of @number@ years during which @number@ died from breast cancer.
Women were followed for major CVD events , including myocardial infarction ( MI ) , stroke , and CVD death.
Women were followed up for an average of @number@ years to document any breast cancer incidence.
Women were grouped into non-users and users of OC ( all combinations of estrogen-progestin products and the contraceptive vaginal ring ) .
Women were more likely than men to be at risk.
Women were more likely than men to have this complaint ( @percent@ versus @percent@ ) , as were older seniors.
Women were more likely to increase consumption in response to stress / depression than men ( RR1.53 , @percent@ CI @number@ to @number@ ) .
Women were more likely to show normal appearance of lips and some alterations in lips mobility.
Women were more likely to use DM medications in China ( OR = @number@ ) .
Women were not evaluated in this study.
Women were @number@ times more likely to use MI medical services relative to men ( HR = 1.45 , CI @number@ to @number@ ) .
Women were questioned on their awareness of the age-related fertility decline and their views and intentions towards considering undergoing oocyte cryopreservation.
Women were recruited by advertisements in primary care neighborhood centers across the city.
Women were shocked about the likely effect of UV exposure on their skin.
Women were significantly more pain-sensitive than men for @number@ of @number@ measures.
Women were significantly older than men in all the surveys ( P < @number@ ) .
Women were slower in age groups 25-29 to 70-74 years.
Women who are going through the menopause transition can experience physiological symptoms that significantly impact their quality of life.
Women who banked accept a higher maximum age for motherhood when compared with non-bankers ( @number@ versus @number@ years ; P < @number@ ) .
Women who deliver via cesarean are not immune to age-related deterioration of anal sphincter function.
Women who did not achieve a pregnancy with IVF / ICSI were older than those who did ( P < @number@ ) .
Women who had any condition that could affect the measurements were excluded from the study.
Women who had undergone forceps delivery in the selected years were matched with women who had SVD in the same year.
Women who regularly practice yoga find that they are able to enjoy menopause and experience the freedom , liberation , and energy that it brings.
Women who reported more fatigue had significantly higher norepinephrine and lower HRV before and after the stressor than their less fatigued counterparts.
Women who underwent bilateral oophorectomy showed no increased risk of glaucoma in the overall group ( HR , @number@ @percent@ CI , @number@.89-1.42 ) .
Women will now live a third of their life after menopause'.
Women with a GDM history are at increased risk of developing diabetes and cardiovascular diseases.
Women with a history of hypertension in pregnancy are at increased risk of microalbuminuria later in life.
Women with a history of thyroid disease , oophorectomy or premature menopause were excluded from the study.
Women with a later acrophase performed worse on categorical fluency ( d = @number@ words , P < @number@ ) .
Women with anemia reported lower intakes of energy , protein , folate , vitamin B-12 , iron , vitamin C , and red meat.
Women with a septum size larger than one-half of their uterine length have a higher chance of successful pregnancy after hysteroscopic septoplasty.
Women with elevated DS showed baseline multidomain cognitive deficits but longitudinal declines in global cognition only.
Women with endometriosis and PCOS have lower antioxidant production capacity that may contribute to abnormal follicular development and infertility.
Women with folate deficiency may be more susceptible to the epigenetic effects of environmental arsenic exposure.
Women with genitourinary prolapse show signs of herniosis in the pelvis.
Women with good physical and psychosocial health are more likely to have a better QOL.
Women with higher 25OHD3 concentrations have more favorable lipid profiles , including increased HDL-C , lower LDL-C , and lower TG.
Women with higher levels of self-esteem exercised greater power in their relationships with their partner.
Women with hysterectomy were not higher in negative affect or negative attitudes toward aging and menopause compared with women without hysterectomy.
Women with late only , persistent , and diverse and persistent CE reported significantly better health compared to non-involved women.
Women with liquid stool FI losing at least @number@ kg and / or increased dietary fiber intake had improved FI frequency.
Women with Low-LAMS / High-VAT presented similar metabolic risks to those with High-LAMS / High-VAT.
Women with normal pregnancy were matched for age , nulliparity , smoking , previous gestational hypertensive disorders , and family history of cardiovascular disease.
Women without sleep disturbance showed better HRQoL.
Women with PCO by volume had higher anti-Müllerian hormone and free androgen index but did not differ in any other hormonal or metabolic parameter.
Women younger than age @number@ years had lower mean EPTs than those older than age @number@ years ( P = @number@ ) .
Word-by-word reading times and comprehension ( e.g. , who scratched ? ) were measured.
Word-list learning tasks are among the most important and frequently used tests for declarative memory evaluation.
Word naming in Spanish.
Word naming times and psycholinguistic norms for Italian nouns.
Word recognition in competing message ( WRCM ) was measured using the Northwestern University No. @number@ word list.
Words and nonwords were used as stimuli to assess item and associative recognition memory performance in young and older adults.
Work ability was assessed through the workability index.
Work ability was assessed with the subjective work ability index ( WAI ) .
Work capacity assessment and family caregiving were deemed to be the most pressing research priority areas.
Workers > 60 years did not experience more problems and barriers compared with workers between @number@ and @number@ years of age.
Workers ' ability to delay retirement depends partly on the demands of their jobs.
Workers ' feelings of shame , complicity , and empathy help explain a defense of the Other.
Workers in this field are prone to burnout , a form of emotional exhaustion at work.
Workers reported time pressures and the frequency of experiences of physical violence and unwanted sexual attention , as we explain.
Workforce planning in an era of health care reform is a challenge as both delivery systems and patient demographics change.
Work in cognitive and affective neuroscience has begun to characterize behavioral and neural responses to emotional cues that systematically change with age.
Working around the dura that will require to be thinned down before the osteotomy is performed represents another challenge where incidental durotomies are not infrequent.
Working at the nanoscale means to completely rethink how to approach engineering in the body in general and in the eye in particular.
Working directly with patients and families ; @number@
Working long hours may be related to obesity in older adults.
Working memory accounted for only a small proportion of the variance in all spatial tasks and had no effect on spatial self-assessments.
Working memory and age , as well as hearing loss , were also the most consistent predictors of overall listening performance.
Working memory and other cognitive skills may modulate older listeners ' ability to use context information to alleviate the effects of noise on spoken-word recognition.
Working memory and verbal abstract reasoning were relatively intact.
Working-memory capacity partially accounted for age-related changes in sentence-production abilities.
Working memory capacity was also found to be associated with improved rule-based and natural auditory category learning , but not information-integration category learning.
Working memory decay in advanced age has been attributed to a concurrent decrease in the ability to control interference.
Working memory declines with normal aging , but the nature of this impairment is debated.
Working memory did not facilitate speech recognition in noise for either group.
Working memory is a complex psychological construct referring to the temporary storage and active processing of information.
Working memory is usually tested using DT paradigms.
Working memory performance in AT-carriers did not differ between young and middle-aged subjects , but was significantly impaired in old age.
Working memory ( WM ) and intraindividual variability ( IIV ) in processing speed are both hypothesized to reflect general attentional processes.
Working memory ( WM ) declines with age.
Working memory ( WM ) entails maintenance and manipulation of information in the absence of sensory input.
Working memory ( WM ) is an essential component for human higher order cognitive activities.
Working memory ( WM ) is closely related to executive functions , and training of WM has yielded evidence toward cognitive plasticity in older adults.
Working memory ( WM ) shows a gradual increase during childhood , followed by accelerating decline from adulthood to old age.
Working pharmacists and students at pharmaceutical college studied the same case studies of home medical care , and their self-evaluations were compared.
Working with and through music as a resource may enhance social and communication functions.
Working with older adults , however , has always been an unpopular career choice among student nurses.
Workload : @percent@ of @number@ RM ( Repetition Maximum ) .
Work on amyloid imaging and functional magnetic resonance imaging is proceeding and epigenetic studies are progressing.
Work over-commitment ( WOC ) is a personal coping strategy for work stress with excessive striving and a health risk.
Work over the last decade established multiple biological regulatory roles of H2 S , as an endogenous gaseous transmitter.
Workplace interventions should deal with job demands and control to maintain older employees ' work ability in times of working population shrinkage.
Work sector was conceptualized as a mediating variable.
Workshop participants outlined research focus areas , potential collaborations , and partnerships for future action.
Workshops consisted of six , @number@.5-hour sessions offered once per week for @number@ weeks.
Work status does not vary according to time since arrival in Brazil.
Work stressors influence work ability - WA - and increasing age is associated with functional aging.
Work to elucidate other biphasic aging mechanisms is strongly encouraged.
Work was approved by our institutional human subjects review board.
Work was normalized to leg lean mass accounting for gender-specific differences ( specific work ) .
World Health Organization ( WHO ) proposed to be used as an index of the health of elderly independence of functioning.
World population is aging day after day and coronary atherosclerosis disease is becoming a worldwide pandemic disease.
World's aging population is rising and the elderly are increasingly isolated socially and geographically.
Worldwide , ageing societies are bringing challenges for independent living and healthcare.
Worldwide air pollution is a major health concern.
Worldwide , approximately @number@ million develop cardiac arrest annually , making it an international issue.
Worldwide approximately two billion people have a diet insufficient in micronutrients.
Worldwide , colorectal cancer ( CRC ) screening programs have significantly increased the detection of submucosal ( pT1 ) adenocarcinoma.
Worldwide , dementia is the most important contributor to disability in elderly patients.
Worldwide , health care budgets are severely constrained.
Worldwide , older adults account for approximately half of all cancer cases , and this proportion is projected to increase globally.
Worldwide , people engage insufficiently in physical activity , particularly subjects aged @number@ years and over.
Worldwide populations are aging and countries have to prepare for the effects of demographic change in health care.
Worldwide progressive population aging demands consensus development for decision making when treating elderly patients.
Worldwide , stroke is the leading cause of disability in the aging population.
Worldwide the elderly population is increasing.
Worldwide , the number of people aged @number@ years and older steadily grows to a predicted @number@ billion in @number@
Worldwide , the prevalence of focal sclerosing glomerulosclerosis continues to increase in many countries.
Worldwide , the prevalence of type @number@ diabetes is increasing in individuals of Chinese descent.
Worldwide , there are increasing numbers of people who are aged over @number@ years.
Worldwide violence perpetrated by people identifying as Muslim has been a growing fear for people living in the US and elsewhere.
Worryingly , the repertoire diversity declines dramatically in old age.
Worrying was the most common psychological symptom.
Worse classifications of nutritional status obtained by MNA scores were also observed in the more severe stages of the disease , according to the CDR.
Worse hearing was associated with more depressive symptoms for participants with low e-mail use but not for those with average or high e-mail use.
Worsening began between years @number@ and @number@
Worsening memory and HVa occur at earlier ages than abnormal amyloid PET.
Worsening of performance under levodopa in young subjects and the associated effect on ACC may indicate that overstimulation of the dopaminergic system compromises interference control.
Worsening renal function was associated with a decrease in mean red cell count.
Worse performance on Stroop III , Rivermead Behavioral Memory Test , and Happé Cartoons correlated with higher age in carriers , but not controls.
Worse performances were observed in conditions firm surface-closed eyes , firm surface-vertical optokinetic stimulus , F-visual-vestibular interaction , and unstable surface-closed eyes.
Worse positive symptoms were associated with higher IL-6 levels.
Worse SCD predicted faster decline in working memory independently of PiB status.
Worse still , we have not checked the behaviors and conditions that exacerbate the rate of environmental destruction.
Worse subjective physical health was associated with increased somatic anxiety , but not with depression or worry.
Worst performance was observed in the Clinical Test of Sensory Interaction and Balance condition of visual dome-unstable surface.
\ "Worthlessness \ " was defined by one of the @number@ questions from the Geriatric Depression Scale with a yes / no response.
Worth noting is the high percentage of CPA-producing strains of P. commune ( @percent@ ) of which some strains were highly toxigenic.
Worthy of note treatment with polydatin induced a nuclear localization and decreased expression of heat shock protein @number@ and vimentin redistributed within the cell.
Wound healing and scar remodeling are complex , multi-cellular processes that involve coordinated efforts of many cell types and various cytokines.
Wound healing is a natural process of body reaction to repair itself after injury.
Wound healing may be affected , leading to recurrences after hernia repair or primary incisional herniation.
Wound healing slows with age , but the basic biology underlying chronic wounds and the influence of age-associated changes on wound healing are poorly understood.
Wound healing within the oral mucosa results in minimal scar formation compared with wounds within the skin.
Wound-related pain is often associated with skin ulcers and negatively impacts both the patient's quality of life and , indirectly , wound healing.
Wounds represent a growing healthcare problem due to an aging population.
WRAP53β rapidly localizes to DSBs in an ATM- , H2AX- , and MDC1-dependent manner.
Wrinkle area was quantified digitally using facial photographs of @number@ northwestern Europeans ( 51-98 years , @percent@ female ) .
Wrinkle assessments were conducted at baseline and @number@ months after the final treatment session.
Wrinkle depth was measured on masks using multiphoton microscopy.
Wrinkle formation caused by photoaging clearly involves changes in extracellular matrix components and mechanical properties of the skin.
Wrinkles and / or furrows and clinical signs of aging were evaluated using a 4-point scale.
Wrinkles and pigmented spots were evaluated using digital photograph images.
Wrinkle Severity.
Wrinkle severity , improvement and patient satisfaction were assessed.
Wrinkle severity of periorbital , glabellar , and forehead lines was evaluated using 3D imaging and validated assessment scales.
Wrinkle severity was assessed at relaxation using the 4-point facial wrinkle scale at baseline , week @number@ and month @number@
Wrinkle severity was rated using the 5-point Wrinkle Severity Rating Scale ( WSRS ) .
Wrinkles , texture , and pores were @number@ variables relevant to analysis of skin laxity.
Wrinkles , thinning and roughening of skin are some of the symptoms that affect the skin as it ages.
Wrinkles were close , within @number@ centimeter , to carotid artery bifurcation in @percent@ of cases.
Wrinkling is a sympathetic nervous system-dependent process but little is known about the physiology and potential functions of water-induced skin wrinkling.
Wrist fracture is the most common fragility fracture in perimenopausal and young postmenopausal women in USA and Northern Europe.
Written responses to program experiences were also collected.
WRN frameshift mutation is considered a potential pathogenic variation according to the guidelines of the American College of Medical Genetics.
WRNIP1 belongs to the AAA + ATPase family and is conserved from Escherichia coli to human.
WRNIP1 interacts with WRN helicase , which is defective in the premature aging disease Werner syndrome.
WS and TMT-A speed have very low concordance ( kappa coefficient = .05 ) .
WS-CoQ10 caused the resumption of autophagy in PSAF.
WS iPSCs also showed recapitulation of the phenotypes during differentiation.
WS iPSCs will provide opportunities to identify affected lineages in WS and to develop a new strategy for the treatment of WS.
WT animals showed no binding changes , irrespective of PVEC.
WTL moderated , but did not mediate , death-related decline in life satisfaction.
WT p53 expression in SF126 cells induced apoptosis and autophagy , and reduced the cell number.
WWOX's alteration in these myriad cancers is due to disparate mechanisms including loss of heterozygosity , homozygous deletion and epigenetic changes.
Xanthine oxidase inhibitors ( XOI ) remain the first-line treatment for hyperuricemia in the elderly.
Xanthine oxidase ( XO ) is a complex metalloflavoprotein , the overproduction of which usually leads to a pathological condition called gout.
Xanthohumol as a natural polyphenol demonstrates an anticancer activity , but its underlying mechanism remains unclear.
Xenobiotics , as well as intrinsic processes such as cellular aging , contribute to an environment that constantly challenges nuclear organization and function.
Xenoestrogens are either natural or synthetic compounds that mimic the effects of endogenous estrogen.
Xeomin and DYS presented similar results regarding fields of muscular effects.
Xeroderma pigmentosum group A ( XPA ) is a classic DNA repair-deficient disorder with patients displaying sun sensitivity and cancer susceptibility.
Xerosis causes pruritus , which then leads to excoriations and risk of skin infections.
Xerostomia was assessed by questioning participants.
XFEM modeling shows potential as a macro-level analysis enabling fracture investigations of clinical cohorts , including at-risk groups , and the design of robust implants.
Xinjiang Province , China is recognized for the longevity of its inhabitants.
XLIF has the ability to correct sagittal plane deformity , although it is most effective at lower lumbar levels.
XLIF significantly improves coronal plane deformity in patients with adult degenerative scoliosis.
XPA patients also exhibit neurodegeneration , leading to cerebellar atrophy , neuropathy , and hearing loss , through a mechanism that has remained elusive.
XP belongs to the group of DNA repair defective disorders that are mainly diagnosed in the clinic and in hindsight confirmed at the molecular level.
XPD genotype was determined by Amplification Refractory Mutation System ( ARMS ) while XRCC1 was genotyped using the PCR-RFLP method.
XPG incision defects result in the cancer-prone syndrome xeroderma pigmentosum , whereas truncating mutations of XPG cause the severe postnatal progeroid developmental disorder Cockayne syndrome.
XPG is a structure-specific endonuclease required for nucleotide excision repair ( NER ) .
XP helicase patient phenotypes cannot be predicted from the mutation position along the linear gene sequence and adjacent mutations can cause different diseases.
XP patients have a markedly increased risk of ultraviolet-induced neoplasms and premature aging of sun-exposed tissue.
X-ray diffraction was used to determine the mineralogy of encrustations for a group of stent samples characterized by relatively high amounts of deposited material.
XRD results revealed no form conversion of EGCG in its transfersomal form.
Xu method was used to calculate CHCE , and a logit model was estimated to show the association between CHCE and bridge employment.
YAP overexpression in cultured podocytes increased the abundance of extracellular matrix-related proteins that can contribute to fibrosis.
YA reduced their gait speed more than OA to achieve a similar pace to safely perform WT.
Yearly clinical evaluations showed that @number@ of the older cohort declined in cognitive function.
Yearly drug expenditure per user of a particular drug was assumed to remain unchanged.
Yearly growth has decreased since @number@ especially since @number@ but , at @percent@ per year , exceeds any other industry and GDP overall.
Yearly pharmacotherapy costs were €693.
Year @number@ was an open label continuation.
Year one was a randomized , double blind trial.
Years in each dependency state were calculated by Sullivan's method.
Yeast samples were taken as a smear from the palate.
Yellow-orange carotenes that deposit in lipid-rich tissues are only produced by plants and are acquired from the diet.
YEM increased more among participants who were aged > 75 years old at baseline ( P < 0.0001 ) .
Yet age remains the single most important determinant of male and female fertility , either natural or treated.
Yet , age-stratification and post-hoc analyses showed that most of these associations were confounded by age.
Yet androgen depletion therapy , now used to treat prostatic hyperplasia , appears to accelerate other aspects of aging ( e.g. cardiovascular disease ) .
Yet , a role of mTOR / S6K1 in aging-associated vascular endothelial dysfunction remains unknown.
Yet , a small but significant age-related increase in CV was evident in horizontal GRFs.
Yet a substantial percentage acknowledged at least some degree of cognitive or physical decline.
Yet , at the same time , there is evidence that TTA estimates themselves are influenced by object approach speed.
Yet , by the elderly , walking is often no longer performed automatically.
Yet , collection of BM is an invasive procedure associated with significant discomfort to the patient.
Yet , despite a large reference panel size and dense genotyping density , very rare variants remain difficult to impute.
Yet , economic evaluations are essential for providing information to policy makers for resource allocation.
Yet , efficient liver repopulation by transplanted hepatocytes is low in livers of old animals.
Yet , emerging evidence suggests that viral suppression will inadequately control inflammation and mitigate risk for progressive brain injury.
Yet , expenditures on treatment of these minor disorders are unwarranted.
Yet few , if any , common solutions exist to support the science of neuroimaging.
Yet few studies have decomposed risky choice to investigate the underlying mechanisms or tracked their differential developmental trajectory.
Yet , few studies have evaluated changes in the expression of cytokines within skeletal muscle after exercise training.
Yet , genetic studies still offer a powerful means of advancing individualized care for HIV-infected individuals at risk.
Yet , gerontological research is sparse and the few studies of older Romanians that exist are not well used by policy makers.
Yet , glutamate reuptake activity was drastically decreased according to the decreased GLAST and GLT-1 expression.
Yet good data are sparse , and it is premature to recommend guidelines.
Yet , how the use of intramuscular carbohydrate and lipid energy stores are coordinated during different types of exercise remains a subject of debate.
Yet , improvement in diet is needed because overall quality did not achieve current recommendations.
Yet , increasingly powerful and complex drug combinations are used to treat patients with chronic diseases and multiple health conditions.
Yet , information regarding the directional changes of CRRT associated with age , body sites and gender is not yet available.
Yet , in hippocampus as well as cortex GLAST and GLT-1 expression was decreased.
Yet , initial treatment of AHF today is similar to @number@ years ago.
Yet insufficiently understood is the contribution of subcortical structures in ambiguity processing.
Yet , issues of access and usability remain to be solved for their usefulness to be fully realized.
Yet , it is believed that men do not age faster than women but simply are weaker at every age.
Yet it is increasingly common for couples at advanced ages to conceive children.
Yet , it is unclear whether variation in liver availability is arbitrary and a disparity requiring rectification or reflects differences in access to care.
Yet , it is untreatable in the large fraction of all AMD patients that develop the early dry form.
Yet , it remains to be answered whether this synergism is the driving force behind Alzheimer disease ( AD ) dementia.
Yet , it remains to be developed how the assessed health strengths / resources-profile may be integrated into AHA management.
Yet less is known about how the functional interactions of these regions with the cerebral cortex and the cerebellum change throughout the lifespan.
Yet little has been known about the details of their characteristics in terms of patient types or differences / similarities across regions.
Yet little is currently known about amino acid-containing compounds affected by isoLG modification in different age-related pathological processes.
Yet , little is known about how healthcare professionals fulfill these roles and what their experiences are like.
Yet , little is known about how this effect varies through adulthood as a function of reading skill.
Yet little is known about how value signals for food and other rewards are constructed by the brain.
Yet , little is known about the mental health needs of older adults from various Asian subgroups compared to non-Hispanic whites.
Yet , little is known about the myriad of ways that older adults experience their sexual lives.
Yet little is known about the patients ' personal delirium experiences.
Yet little is known about the RVU's effect on geriatric programs.
Yet , little is known among health care providers about the older adult's experience of home.
Yet , many cases are idiopathic or await the identification of molecular causes.
Yet many EM residencies lack curricula or assessment tools for competent geriatric care.
Yet many exposed individuals do not become depressed.
Yet many people play an instrument for a few years without making a lifelong commitment.
Yet , many who carry it never develop dementia.
Yet many will age out of foster care into adulthood without an adoptive family.
Yet , measures have not been validated in regions with various levels of socio-economic development.
Yet methodological challenges associated with establishing common assessment and classification procedures hamper the construct.
Yet , microglia often are described as neurotoxic cells , that actively kill ( healthy ) neurons.
Yet modified informed consent processes that assess participants ' comprehension of the risks and benefits of participation are not required by relevant federal guidelines.
Yet most human aging research examines older adults , many with chronic disease , and little is known about aging in healthy young humans.
Yet most medical research remains focused on combating individual diseases.
Yet much remains to be learned about causal relationships , and large gaps remain in our understanding of epigenome-transcriptome interactions.
Yet nearly half felt monitoring RE-AIM requirements requires special expertise , and one third felt the different RE-AIM elements were difficult to measure.
Yet , neither the validity nor the accuracy of the available tests is firmly established.
Yet , no instruments were found to measure connectedness.
Yet , no longitudinal studies have examined the neurocognitive effects of physical inactivity in HF.
Yet , not all individuals with life experience are wise.
Yet , not much is known about the molecular alterations underlying this reactive phenotype.
Yet , observational studies typically associate weight loss with higher mortality risk.
Yet often , tests of episodic memory use verbal material to be recalled ( word lists , stories ) .
Yet , older adults are not a homogeneous group.
Yet , older adults score higher than younger adults , consistent with most reports of vocabulary outcomes in the cognitive aging literature.
Yet , other anatomical characteristics have important impacts on the type of treatment and prognosis.
Yet , our data do not support the previously reported associations of HPGD tagSNPs and risk of CRC.
Yet , our knowledge of their etiology remains rather limited.
Yet our progress toward delineating the precise contributions of mtDNA mutations to these conditions is impeded by the limited availability of faithful transmitochondrial animal models.
Yet , @percent@ of participants report it would not occur to them to initiate a discussion with a widowed friend about the friend's loss.
Yet performance trade-offs are rarely detected , and traits are often positively correlated.
Yet pharmacologic and clinical data are lacking.
Yet population aging is a global phenomenon that will continue to affect all regions of the world.
Yet potential age-related changes in flow during stimulation may affect the blood oxygenation level dependent ( BOLD ) response used to investigate cognitive neurodevelopment.
Yet PRP has not gained wide popularity in aesthetic surgery as a result of uncertainty surrounding objective clinical evidence.
Yet , pubertal maturation is associated with increased reactivity in threat-avoidance systems.
Yet , research has shown that nearly half of dementia patients are receiving such medication.
Yet , research on barriers and how they can be alleviated is lacking.
Yet , research suggests this relationship is not straightforward.
Yet RPP income for all other immigrant cohorts remained stable or declined during these decades.
Yet several studies have revealed age-related alteration of motor imagery ( MI ) ability , suggesting that mental training is not applicable for older adults.
Yet similar if not overall higher benefits are achievable with regular exercise , a drug-free intervention for which our genome has been haped over evolution.
Yet six of @number@ patients were carriers of genetic mutations , one GBA , one LRRK2 , one POLG1 and three PINK1.
Yet , state-of-the-art pipelines and services for human nuclear genome variant calling and annotation do not handle mitochondrial genome data appropriately.
Yet , studies of the factors associated with TV viewing have predominantly been cross-sectional.
Yet , surprisingly absent is any consideration of how weather conditions modify the impact of neighbourhood walkability.
Yet , systematic studies , especially those investigating different modalities or types of memory , have not been done.
Yet , T421 / S424 and S235 / 236 ( p-S6K and p-S6 , respectively ) phosphorylation became rapamycin-insensitive in the presence of PMA.
Yet , telomerase is intimately related to photo-aging in which lifetime cumulative sun exposure is an important factor.
Yet , the age related chronic inflammation is believed to be pathogenic with regards to its contribution to frailty and degenerative disorders.
Yet the association between MCI and ET has only been examined in one prior study.
Yet the conventional nuclear family model is increasingly uncommon as new , pluralistic models of family life are emerging in contemporary society.
Yet the data that are available do not support this concern.
Yet the developmental trajectory of quality of life is not well understood.
Yet , the effect of stimulus properties on performance has not been fully investigated.
Yet , the effects of aging and obesity on inflammatory responses to immunotherapeutics are not well defined.
Yet , the extent to which 25 ( OH ) D status affects cognitive performance remains unclear.
Yet , the functional neural substrates that support locomotion are not well established.
Yet the infant behaviours involved present differently , at separate ages and times of day.
Yet , their intakes remain remarkably variable both within and across populations , which could partly owe to genetic influences.
Yet , their interrelations are insufficiently understood.
Yet the level appears sufficient for available training places.
Yet , the life-years gained are often spent with multiple chronic and slowly progressive conditions , and this particularly applies to patients with cardiopulmonary disease.
Yet the majority of preceding research has been focused on physical performance.
Yet the mechanisms that control their development remain poorly defined.
Yet the molecular regulation accounting for these similarities is not fully understood.
Yet , the neural correlates of gait are not well established , because most neuroimaging methods cannot image the brain during locomotion.
Yet , the neural mechanisms of over-recruitment in older adults ( OAs ) are largely unknown.
Yet , the neural underpinnings of the integration of eye gaze and emotional facial cues are not well understood.
Yet the neurobiological mechanisms contributing to the development of functional and structural brain connections remain to be poorly understood.
Yet , the prevalence of cognitive impairment in specific cognitive domains in COPD has been poorly studied.
Yet the prognostic values of heart rate variability and baroreflex sensitivity in the risk of new-onset ambulatory hypertension have not been investigated.
Yet the prospect of treating ageing is extraordinary in terms of the profound changes to the human condition that would result.
Yet the real relationship is indirect , reliant on numerous assumptions , and subject to several sources of noise.
Yet there are few studies of the relationship between bone mineral density ( BMD ) and mitochondrial content in humans.
Yet there are no studies or trials that directly evaluate how interventions of arterial stiffness reduce or prevent cognitive impairment and risk of developing dementia.
Yet , there are remarkable individual differences in brain health and memory performance among OA.
Yet , there are surprisingly few health studies that have recognized the aging of the Aboriginal population.
Yet , there is a paucity of data describing the cosmetic concerns of this population.
Yet , there is little information on changes in satellite cell content from birth to old age in humans.
Yet , there is little in the literature on the management and outcome of these fractures.
Yet there is little support for sexual expression in later life , particularly among young adults.
Yet , there is no correlation between amyloid plaques and the degree of dementia.
Yet the relative impacts of both conditions on microglia are less frequently considered in concert.
Yet , there remain few studies that focus on healthcare utilization and its relationship with comorbidities in these elderly mentally ill patients.
Yet , there remains a gap between recommended practices and current clinical activities.
Yet , these programs pay little regard to a critical first step-the personal goals of older adults.
Yet , these three alternatives represent only a few of the many non-amyloid mechanisms that can explain AD pathogenesis.
Yet , the UK has no routinely available , national data on health in care homes.
Yet , the underlying mechanisms of the effect of CCT on cognition remain poorly understood.
Yet , the ways to develop and integrate best geriatrics training within the context of hematology / oncology fellowship remain unclear.
Yet , this has been relatively unexplored , particularly in minority populations with high cardiovascular burden.
Yet , this has seldom been examined empirically.
Yet , this interpretation rests on empirical assumptions about the uniformity of item-response functions between groups.
Yet , this is a captivating and testable hypothesis.
Yet , this is not done without risk.
Yet this tremor mainly has been studied within the context of advanced age rather than among the vast bulk of adults who are not elderly.
Yet , this turning point was predicted a decade ago.
Yet unrelated individuals do share receptors , which together constitute a \ "public \ " repertoire of abundant clonotypes.
Yet , until now , no study has evaluated the existing evidence of the diagnostic accuracy of CDRs for VTE in elderly.
Yet , we understand little about how these pathways achieve physiologically responsive stem cell functions.
Yet , what is causing stem cell and immune-senescence ?
Yet , whether high WMH burden is related to the excess cognitive impairment present in older adults with BD is unknown.
Yet with all of our current knowledge of tumor biology , the details of early oncogenesis have been difficult to observe and understand.
YFAS outcomes were related to a range of other eating behavior measures and anthropometrics.
YGR146C encodes a functional homolog of ecl1 ( + ) , ecl2 ( + ) , and ecl3 ( + ) of Schizosaccharomyces pombe.
YLDs and cost were generally lower in South-European countries , and prevalence was lower in North-European countries , but no significant differences were found.
YLDs have the same value as disability-adjusted life years as there is no evidence of mortality associated with neck pain.
YLHIV cared for at adult sites had poorer retention and cART outcomes compared to YLHIV cared for at pediatric sites.
YLHIV cared for in adult clinical sites have poor retention and antiretroviral treatment initiation , and @number@
YME1L1 was also mutated in tumors derived from other tissues.
Yoga is an exercise with both physiological and psychological effects on aging.
Yoga practice may be an effective adjunctive treatment for a clinical and healthy aging population.
Young adult ApoE4 mice ( 10-12 week-old ) from both sexes displayed reduced neurogenesis compared with wild-types and the other genotypes.
Young adult childhood cancer survivors are at an increased risk of frailty , a physiologic phenotype typically found among older adults.
Young adulthood is a critical developmental period for establishing life-long health behaviors.
Young adult rats treated with 17β-estradiol had significantly decreased infarct volumes and improved functional outcome compared with ovariectomized young adult rats.
Young adults accepted fewer false verbal actions than visual ones and awarded fewer remember judgments to their false alarms for verbal than for visual actions.
Young adults are associated with higher baseline HRV during the daytime.
Young adults believed they communicated their message clearly , and older adults evaluated their own communication even more favorably.
Young adults ' brain systems exhibit a balance of within- and between-system correlations that is characteristic of segregated and specialized organization.
Young adults exhibited stronger indices of joint coordination , evidenced by a larger increase in VORT after removing joint covariation than for older adults.
Young adults had better precision for cortical thickness ( @number@ % , MOD ) and tibial cortical density ( @number@ % , AUTO ) .
Young adults , in contrast to older adults , believed that gains in CP began and ceased at an earlier age.
Young adults ( @number@ years ) and older adults ( @number@ years ) performed a lexical decision task.
Young adults outperformed older adults in visuomotor adaptation tasks and in cognitive tasks.
Young adults performed more accurately , albeit not significantly so.
Young adults present mainly with primary MR , while secondary MR is more common in elderly ones.
Young adults previously broke gaze anchoring at the first target only when the second pointing was excluded ( HS1 ) .
Young adults retained significantly more words following a nap interval than a quiet wakefulness interval on both free recall and recognition tests.
Young adults seemed to rely solely on procedural memory , or repetition , to learn tunes.
Young adults showed higher opsonic capacities than older adults for serotypes @number@ and 23F.
Young adults showed large composite effects for faces , but none for watches.
Young adults with chronic diseases do not fit easily into an aging adult patient population and are frequently isolated from peers.
Young adults with low working memory performance also showed this penalty ( Experiment @number@ ) .
Young age and sexual activity are risk factors for mesh exposure.
Young ( aged 18-25 ) and older ( aged 50-64 ) women performed full-body high-intensity resistance exercise three times per week for eight weeks.
Young age seemed to depress mostly polyfunctional ( IL2 + IFNγ secreting ) CD4 in both infections.
Young and adult individuals are known to respond to radiation in a different manner.
Young and aged mice were placed on a diet that either lacked sulfur-containing amino acids ( SAAs ) or had @percent@ OTC for @number@ weeks.
Young and elderly adults were trained to perceive the lengths of unseen , handheld rods.
Young and elderly CI users and age-matched NH listeners performed a speeded response task on basic auditory , visual and audio-visual stimuli.
Young and elderly participants performed a categorization task ( indoor vs. outdoor ) on LSF and HSF scenes.
Young and elderly patient groups aged 25-40 years and 60-85 years , respectively , were included.
Young and middle-aged adults did not generate an asymmetric N170 component.
Young and middle-aged dogs showed more vocalisations in response to social isolation.
Young and older adults differ in how many strategies they use to accomplish cognitive tasks.
Young and older adults learned a visuospatial task , and recall was probed after sleep or wake.
Young and older adults performed an associative recognition task while electroencephalogram ( EEG ) was recorded.
Young and older adults searched for a unique face in a set of three schematic faces and identified a secondary feature of the target.
Young and older adults showed significant slowing when the exact prospective-memory cue was presented.
Young and older adults studied a list of categorized words and took three successive recall tests.
Young and older adults studied a mixed list of categorized words , and later recalled items when cued with each category.
Young and older adults viewed a series of actors performing different actions.
Young and older healthy adults carried out a semantic judgment task while their cortical activity was recorded using magnetoencephalography ( MEG ) .
Young and older normal controls were compared to early AD patients using psychophysical measures of visual word and motion processing.
Young and older participants judged the veracity of young and older speakers ' opinions about topical issues.
Young and older participants living in the community performed the tasks from the standing position.
Young and old participants performed a change-detection task where some items in the encoding display were marked as irrelevant.
Young and old participants showed differences in the handling of the perturbation in the course of several trials.
Young and old showed similar fatigue following a series of brief , intermittent contractions , but women fatigued less than men.
Young and old subjects were tested on their memory for paired-associate terms when cued with either facilitative or misleading word stems.
Young but not older patients with RA may sustain obesity-induced endothelial activation that is directly mediated by leptin.
Young children showed patterns similar to cerebellar patients , with greater deficits in spatial versus temporal adaptation.
Young compared to older adults exhibited superior syntactic performance and stronger FC within the mainly left-lateralized syntax network , which was beneficial for performance.
Young consumers are more open to high-technology food processing.
Young dancers are less efficient at controlling their balance than adult dancers.
Young did not differ from older adults in RT variability or in single trial delta / theta ITC.
Young dogs displayed more interactions involving physical contact with a person.
Younger adults displayed increased correspondent inferences following mortality primes , whereas older adults ' inferences were not affected by the reminder of death.
Younger adults elicited increased activity when forming negative impressions , while older adults had more recruitment when forming positive impressions.
Younger adults had a greater extent of frontal caudate functional connectivity during the load-dependent delay period of the working memory task than the older participants.
Younger adults improved performance with increased conflict frequency , whereas older adults did not.
Younger adults may be more resilient to the effects of recent mild TBI than older adults.
Younger adults , older adults , and DA performed similarly when the condition employed all pre-experimentally known , semantic , relations.
Younger adults , on the other hand , showed no difference in false alarms to the @number@ types of rearranged pairs.
Younger adults recalled more landmarks from semantically organized maps compared with older adults.
Younger adults showed no priming from the distracting information in either experiment , whereas older adults showed reliable priming in both experiments.
Younger adults showed the typical startle blink pattern , with potentiated startle when viewing negative pictures compared to positive pictures.
Younger adults with anxiety disorders are known to show an attentional bias toward negative information.
Younger age , a lower DAS28 score , and a lower DAS28-P score at baseline were related to a good EULAR response.
Younger age and longer duration of statin therapy was associated with greater benefit while a benefit was not observed among older persons.
Younger age-at-baseline predicted lower BMI level and lower rate of increase.
Younger age at cranial irradiation and higher dosage were associated with worse outcome of WM integrity.
Younger age at diagnosis was associated with lower intelligence quotient and academic achievement scores , even many years after treatment had been completed.
Younger age quartiles showed greater improvements in AMS , MFI , BMI , and waist circumference than older quartiles.
Younger age , smaller tumor size , and fewer baseline comorbidities predict better survival.
Younger and healthy older participants performed a masked auditory number comparison while EEG was recorded.
Younger and less absorbent lenses showed smaller changes than older and more absorbent lenses.
Younger and less mentally frail populations showed stronger associations.
Younger and middle age groups were most commonly affected in both sexes.
Younger and older adults attempted to remember events in which a person performed a negative , positive or neutral action.
Younger and older adults completed gain , loss , and mixed-domain choice problems as well as measures of cognitive functioning and affect.
Younger and older adults engaged in delayed recognition tasks both with and without interruption by a secondary task.
Younger and older adults judged whether decomposable and nondecomposable idioms and nonidioms had a literal interpretation.
Younger and older adults performed a perceptual discrimination task in which bicolored stimuli had to be classified according to their dominating color.
Younger and older adults practiced a 16-element movement sequence with one limb on Day @number@ and the contra-lateral limb on Day @number@
Younger and older adults watched and segmented a narrative film , The Red Balloon , into coarse and fine events.
Younger and older adults were presented with streams of short speech stimuli.
Younger and older adults were shown a context word superimposed on a to-be-ignored picture , followed by a test word.
Younger and older listeners adapted to this accent , but older listeners showed poorer comprehension of the accent.
Younger and older participants performed an attentional tracking task in one hemifield while distractor objects were concurrently presented in the unattended hemifield.
Younger and older participants performed machine-paced assembly tasks , while the kinematics of upper extremities were recorded using a motion tracking system.
Younger and older participants were asked to detect deceit from videos of younger and older speakers , rating their confidence in each decision.
Younger cancer patients were vulnerable to depressive symptoms and should be monitored carefully.
Younger candidates for refractive surgery should be screened for temporal forme fruste.
Younger caregivers , caregiving sons , caregivers not living with care recipients , and having supplemental paid caregivers were associated with more unmet needs.
Younger cases and ever smokers smoking less than median pack-years showed significantly increased risk of death associated with the XPA -4A allele.
Younger FPAs were more compliant longitudinally but became more isotropic with age.
Younger listeners exploit stimulus-inherent acoustic detail , but are they also actively predicting upcoming information ?
Younger males expressed a lack of support from friends and family.
Younger men and those with less severe erectile dysfunction had longer IELTs and MELTs.
Younger moesin-deficient mice exhibited elevated basal levels of several Ig isotypes and enhanced Ab affinity maturation upon immunization.
Younger monkeys drove these relationships , with HSP70 alone being predictive of insulin changes with aging.
Younger ( N = @number@ ) and older ( N = @number@ ) adults were tested on a computerized recollection and familiarity task.
Younger onset was also a risk factor for poor emotional well-being independent of depression status.
Younger participants had a larger volume of activity in the amygdala but less in the prefrontal cortex than the old.
Younger participants significantly benefited from using this technology.
Younger participants were presented with pictures of unfamiliar younger and older faces in the context of a gender categorization task.
Younger patients are more likely to have posterior foci than older ones.
Younger patients showed cystic retinal elevation , whereas older patients showed collapsed retinoschisis with retinal thinning.
Younger patients with type @number@ diabetes suffer from DKA ; inappropriate insulin therapy or infection is usually the trigger.
Younger skin has a greater subsurface reflectivity and a more even surface reflectivity.
Younger subjects had a greater change in muscle elasticity with exercise.
Younger subjects were taller , and despite having longer axial lengths , their bigger eyes were still predominantly emmetropic.
Younger veterans averaged @number@ fewer days in GPD.
Younger women generally have lower blood pressure and sympathetic activity than younger men.
Young , fit individuals may experience exertional heat stroke while performing strenuous physical activity in temperate or hot climates.
Young masseter and biceps were similar in that type I fibres outnumbered other fibre types and were of the same diameter.
Young masseter differed from young biceps also by smaller type II fibre diameter and by containing fetal MyHC.
Young men prefer meat products in the role of functional carriers.
Young ( @number@ months ) and aged ( @number@ months ) DJ-1 knockout ( DJ-1 KO ) and age-matched wild-type mice were examined.
Young ( @number@ weeks ) and aged female ( 16-17 months old ) wild-type ( WT ) and Cyp2e1-null mice were used.
Young-old adults had significantly longer reaction times.
Young Old and Older patients improved to a similar degree on measures of depression and delusions from baseline to treatment end.
Young-old and old-old adults , but not young adults , experienced more TOTs for words beginning with low-frequency first syllables relative to high-frequency first syllables.
Young participants showed a positive correlation for contralateral SMA and SM1.
Young participants showed higher total and mitochondrial derived semitryptic peptides and 26S proteasome activity indicating increased protein degradation.
Young participants showed significantly facilitated MEPs in the respective muscle needed for wrist flexion or extension.
Young participants , showed the largest shift in SEC patterns between the less demanding SA task and the more demanding 2-back task.
Young people still have a classic perception of old age.
Young PM carriers can develop characteristic physical features and mild cognitive disabilities.
Young produced less complex sentences when rewarded for tracking and produced more complex sentences when rewarded for talking.
Young's modulus increased significantly with age in humans ( p = @number@ ) .
Young's modulus was calculated from the force-indentation curves using the model of Sneddon for a conical indenter.
Young smokers had a significantly higher Nb-Pb amplitude and shorter Nb latency than other groups.
Young subjects and TCPs demonstrated better performance outcome and performance production than ONPs.
Young subjects were also asked to stand up with their trunk purposely bent forward.
Young women aged 15-24 years have the highest rates of sexually transmitted infections ( STIs ) .
Young women are relatively protected against risk of hypertension due to greater peripheral vasodilator influences compared with young men and older people.
Young women reported the greatest cancer-related concern ( P < @number@ ) .
Young women were scanned at @number@ discrete phases of the menstrual cycle ( midcycle and late luteal ) .
Young women who drop out have overall more partners.
Young women with hyperuricemia had the highest risk of MS. BACKGROUND : Dyskinesia is a kind of abnormal involuntary movement disorder that increases with age.
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Youth completed the Chatroom Task while undergoing functional magnetic resonance imaging.
Youth displayed larger CRN and N2 , attenuated Pe , and significantly worse task performance than younger adults.
Youth identified limited self-efficacy and insufficient psychosocial supports \ "cueing action \ " during their transition out of foster care.
Youths with disabilities face numerous challenges when they transition to adulthood.
YPLL rate was positively correlated with mortality in all periods.
YPLL rate ( YPLLs per @number@ ) in 1973-1975 was higher than those in 1990-1992 and 2004-2005.
YT and AT participated in a high intensity sprint and strength training program ( HISST ) for @number@ weeks.
Yttria partially stabilized tetragonal zirconia polycrystalline ( Y-TZP ) showed better mechanical properties and superior resistance to fracture than other conventional dental ceramics.
( Zanthalene ® ) as an anti-itching cosmetic ingredient.
Zebrafish ( Danio rerio ) have one β1AR gene and two β2AR genes ( β2aAR and β2bAR ) .
Zebrafish offer unique potential to understand how MLL impacts haematopoiesis from the earliest embryonic timepoints and how translocations cause leukaemia as an embryonal process.
Zebrafish show an array of senescence symptoms resembling those in humans , which can be targeted to specific aging pathways conserved in vertebrates.
Zero point was given if CC was < 31 cm and @number@ points were given if CC was ≥31 cm.
Zhang et al.
Zigzag walking time was faster in men than in women.
Zimerman and colleagues ( Zimerman M , Nitsch M , Giraux P , Gerloff C , Cohen LG , Hummel FC.
Zinc deficiency causes abnormal glucocorticoid secretion and increases depression-like behavior in animals.
Zinc deficiency is associated with poor dark adaptation.
Zinc in MS lesions was generally decreased , paralleling myelin loss.
Zinc is also required for the biological action of arginine , via Nitric Oxide pathway.
Zinc is an essential element involved in an individual's physiology.
Zinc is particularly concentrated in the corneal epithelium and posterior stroma.
Zinc is the most abundant trace metal in the retina.
Zinc levels are high in ocular tissues and the distribution is non-uniform.
Zinc levels in the human retina and RPE decrease with age in AMD.
Zinc oxide nanoparticles ( ZnO NPs ) potentially undergo physicochemical transformation in the environment , which may lead to unexpected environmental and health risks.
Zinc status and polymorphisms of genes coding for zinc-transporters have been associated with chronic diseases.
Zinc was unaffected in any disease pathologies and no age-associated changes were apparent.
ZIP4 is predominantly expressed in human keratinocytes , and its expression is dramatically reduced on epidermal differentiation.
ZMPSTE24 and LHFPL2 demonstrated altered expression in late passage skin cells only ( p = @number@ and @number@ respectively ) .
ZNF216 gene has been identified as one of Immediate Early Genes ( IEGs ) induced by RTKs.
ZNF804A , encoding the transcription factor zinc-finger protein 804A , is a genome-wide supported psychosis gene associated with schizophrenia and bipolar disorder.
Zol is not recommended for patients with severe renal impairment.
Zone of origin may be important to consider in prostate tumor biomarker research.
Zone of origin may have prognostic value or reflect distinct molecular subtypes ; however , it can be difficult to determine in practice.
Zones examined by the GHT consisted of test locations that did not necessarily belong to the same CSI , particularly in the periphery.
Z-scores identified lumbar ( L1-L4 ) aBMD as osteopenic ( @number@ < Z-score < @number@ ) in trained cyclists ( @number@ ± @number@ ) .
Z scores indicate that older American women performed better in all functional tests than age-matched Brazilians.
Zung Self-Rating Anxiety and Zung Self-Rating Depression Scales scores also contribute to increase lipoperoxides levels , but not significant.
Zymosan-induced ( non-spontaneous ) extracellular ROS levels were also similar for young and nonagenarians but were lower in elders.
Δ40p53 is a transactivation-deficient isoform of the tumor suppressor p53.
ΔNp63αplays key roles in cell survival and proliferation.
ΔPV during exercise was twofold greater in LPLO and NPLO than in CNT.